bluuebunny/crossref_metadata_2025_split huggingface dataset:
Deuterostome Ancestors and Chordate Origins
Authors: Swalla Billie J 
Published: August 2024

Synopsis
The Deuterostomia are a monophyletic group, consisting of the Ambulacraria, with two phyla, Hemichordata and Echinodermata, and the phylum Chordata, containing the subphyla Cephalochordata (lancelets or Amphioxus), Tunicata (Urochordata), and Vertebrata. Hemichordates and echinoderms are sister groups and are critical for understanding the deuterostome ancestor and the origin and evolution of the chordates within the deuterostomes. Enteropneusta, worm-like hemichordates, share many chordate features as adults, including a post-anal tail, gill slits, and a central nervous system (CNS) that deploys similar developmental genetic regulatory networks (GRNs). Genomic comparisons show that cephalochordates share synteny and a vermiform body plan similar to vertebrates, but phylogenomic analyses place tunicates as the sister group of vertebrates. Tunicates have a U-shaped gut and a very different adult body plan than the rest of the chordates, and all tunicates have small genomes and many gene losses, although the GRNs underlying specific tissues, such as notochord and muscle, are conserved. Echinoderms and vertebrates have extensive fossil records, with fewer specimens found for tunicates and enteropneusts, or worm-like hemichordates. The data is mounting that the deuterostome ancestor was a complex benthic worm, with gill slits, a cartilaginous skeleton, and a CNS. Two extant groups, echinoderms and tunicates, have evolved highly derived body plans, remarkably different than the deuterostome ancestor. We review the current genomic and GRN data on the different groups of deuterostomes’ characters to re-evaluate different hypotheses of chordate origins. Notochord loss in echinoderms and hemichordates is as parsimonious as notochord gain in the chordates but has implications for the deuterostome ancestor. The chordate ancestor lost an ancestral nerve net, retained the CNS, and evolved neural crest cells.
Investigating fish reproduction phenology and essential habitats by identifying the main spatio-temporal patterns of fish distribution
Authors: Alglave Baptiste , Olmos Maxime , Casemajor Juliette , Etienne Marie-Pierre , Rivot Etienne , Woillez Mathieu , Vermard Youen 
Published: August 2024

Abstract
Fish spawning phenology is a major concern for conservation and fisheries management. New intensive data sources, such as GPS-based tracking data and high-resolution catch declaration data, are becoming increasingly available in the field of marine ecology. These data benefit from high spatiotemporal resolution and open new research avenues for investigating the interannual variability in fish phenology. In this paper, we demonstrate how an integrated species distribution model informed by commercial catch data combined with spatiotemporal dimension reduction methods known as empirical orthogonal functions (EOFs) can be used to synthesize spatiotemporal signals in fish reproduction phenology. Specifically, we address the following questions: (1) Can we identify seasonal spatial patterns that can be interpreted in terms of reproductive phenology and essential habitats? (2) Can we identify changes in reproductive phenology over time? (3) Are these changes related to environmental drivers? The analysis illustrates the reproductive phenology of three key commercial species in the Bay of Biscay (sole, hake, and sea bass). The EOF analysis emphasized strong seasonal spatiotemporal patterns that correspond to reproduction patterns and feeding patterns. Based on this methodology, we identified seasonal variations in the timing of reproduction, and we related these variations to sea surface temperature, a key driver of fish reproduction.
Output feedback distributed economic model predictive control for parallel system in process networks
Authors: Zhang Shuzhan , Li Jia , Zhao Dongya , Spurgeon Sarah K 
Published: August 2024

Abstract
This paper proposes a distributed economic model predictive control algorithm for parallel systems which uses only output feedback. Such parallel systems are a fundamental system architecture frequently encountered in process networks where, in many cases, the state of the plant is not measurable. Economic performance is a key consideration in the operation of such industrial plants and it is of interest to develop theoretically rigorous approaches to tackle what is a practically very relevant scenario. The competitive couplings and competitive constraints inherent in parallel systems are explicitly addressed in the proposed controller design framework. Three measures are considered for optimization of such parallel systems including an economic stage cost function, energy efficiency and tracking accuracy. An economic cost function is optimized by the resulting distributed controller which can realize global control performance while also reducing the computational time for large-scale parallel systems. Stability of the system is formally proved using the principles of dissipativity. Finally, the effectiveness of the proposed theoretical approach is verified by both numerical simulation and experimentation to demonstrate practical relevance.
Multichannel seismic attenuation compensation and interpolation with curvelet sparse constraint of frequency-wavenumber spectrum
Authors: Yin Ying , Mo Tongtong , Wang Benfeng 
Published: August 2024

Abstract
High-resolution exploration is hampered by seismic attenuation, caused by the viscosity and heterogeneity of underground media. Conventional single-channel attenuation compensation methods can increase the corresponding vertical resolution partially. However, the lateral continuity of compensated seismic data is always ignored and the noise resistance can be improved. Therefore, multichannel attenuation compensation methods were proposed, including the algorithm with sparse curvelet coefficient constraint of the time-space (t–x) data. However, nonstationary seismic data may be affected by irregular missing traces in field cases, which severely degrades its lateral continuity and negatively affects the performance of multichannel attenuation compensation. Therefore, we concentrate on simultaneous multichannel attenuation compensation and missing trace interpolation in a unified framework. Based on the inversion framework of sparsity promotion, we propose an approach for simultaneous multichannel compensation and interpolation, utilizing sparse curvelet coefficient constraint of the recovered principal frequency-wavenumber (f–k) spectrum. The size of the principal f–k spectrum is reduced by at least half compared with that of the corresponding t–x band-limited data. It significantly reduces the computational expense of curvelet transform-based processing. Synthetic and field data experiments validate the effectiveness of the proposed method in efficiency improvement with consistent performance when compared to the multichannel method with sparse curvelet coefficient constraint of the t–x data in improving the vertical resolution and lateral continuity. Furthermore, we have discussed a potential acceleration strategy based on random sampling in the normal compensation issue.
Multimarket firms and product liability: uniform versus variable rules
Authors: Chen Yongmin , Hua Xinyu 
Published: August 2024

Abstract
When a multimarket firm’s product causes harm to consumers, should the firm bear uniform or variable liability across markets? We analyze a model in which the firm faces the same standard liability in two markets under uniform liability, while its liability rises above and falls below the standard level in markets 1 and 2, respectively, under variable liability. Allowing variation in product liability across markets has broad implications for the firm’s incentive to invest in product safety, total output, and output allocation across markets, as well as for the optimal choice of standard liability in the first place. We show that welfare is higher under variable liability if demand elasticity is lower and demand curvature is weakly higher in market 2 than in market 1, but welfare can be higher under uniform liability otherwise.
Complexity and scalability of defeasible reasoning in many-valued weighted knowledge bases with typicality
Authors: Alviano Mario , Giordano Laura , Theseider Dupré Daniele 
Published: August 2024

Abstract
Weighted knowledge bases for description logics with typicality under a ‘concept-wise’ multi-preferential semantics provide a logical interpretation of MultiLayer Perceptrons. In this context, Answer Set Programming (ASP) has been shown to be suitable for addressing defeasible reasoning in the finitely many-valued case, providing a $\varPi ^{p}_{2}$ upper bound on the complexity of the problem, nonetheless leaving unknown the exact complexity and only providing a proof-of-concept implementation. This paper fulfills the lack by providing a ${P^{NP[log]}}$-completeness result and new ASP encodings that deal with both acyclic and cyclic weighted knowledge bases with large search spaces, as assessed empirically on synthetic test cases. The encodings are used to empower a reasoner for computing solutions and answering queries, possibly interacting with ASP Chef for obtaining an interactive visualization.
Reported snakebite mortality and state compensation payments in Madhya Pradesh, India, from 2020 to 2022
Authors: Kadam Priyanka , Patel Bhupeshwari , Gopalakrishnan Maya , Sirur Freston M , Bharti Omesh K , Agrawal Amit , Yunus Md , Majumdar Dayal B , Ainsworth Stuart 
Published: August 2024

Abstract

Background
India experiences the highest snakebite burden globally, with 58 000 predicted deaths annually. The central Indian state of Madhya Pradesh is thought to have a substantial snakebite burden and provides compensation to families who can demonstrate by postmortem and hospital treatment reports that their relatives have died due to snakebite. This study represents the first report on the frequency of distribution of compensation for snakebite deaths in Madhya Pradesh.

Methods
Statewide snakebite death compensation data from 2020–2021 and 2021–2022, provided by the Madhya Pradesh health authorities, were analysed alongside interviews with 15 families that described the events that ultimately led to their compensation claims.

Results
Compensation was paid to a total of 5728 families, with a total value equating to 22 912 Lakhs (approximately US${\$}$27.94 million). Families described commonly recognised snakebite risk factors and behaviours in the events that resulted in their relatives’ deaths.

Conclusions
The snakebite burden in Madhya Pradesh is significant, both in terms of mortality and economic expenditure of the state. Sustained investment in preventative interventions, as well as monitoring of the rate of compensation payouts due to snakebite death as a measure of intervention effectiveness, should be considered to substantially reduce snakebite incidence and mortality.
Development and Validation of a Sensitive Liquid Chromatography–Tandem Mass Spectrometry Method for Therapeutic Drug Monitoring of Ceftolozane and Tazobactam in Human Plasma Microsamples
Authors: Conti Matteo , Giorgi Beatrice , Gatti Milo , Viale Pierluigi , Pea Federico 
Published: August 2024

Background:
Ceftolozane/tazobactam (C-T) is a novel beta-lactam/beta-lactamase inhibitor combination approved for the treatment of various infections caused by difficult-to-treat Pseudomonas aeruginosa. In critically ill patients, C-T may exhibit significant pharmacokinetic variability, both between individuals and within individuals, warranting therapeutic drug monitoring for clinical purposes. We aim to develop and validate a novel and sensitive analytical method for concurrently determining C and T in human plasma microsamples (3 μL).

Methods:
The method was developed using liquid chromatography–tandem mass spectrometry (LC-MS/MS) with positive electrospray ionization and multiple reaction monitoring (MRM) detection modes, employing specific mass transitions for both drugs. Sample preparation was simple, and the chromatographic run lasted only 4 minutes. Validation was conducted according to European Medicines Agency (EMA) guidelines, encompassing specificity, sensitivity, linearity, precision, accuracy, matrix effect, extraction recovery, limit of quantification, and drug stability. The validated method was applied to measure C and T in 32 plasma samples collected from critically ill patients with multidrug-resistant, gram-negative, bacterial infections.

Results:
The method ensured accurate (BIAS% 2.1–9.6 for C and −2.2 to 15.2 for T) and precise intraday CV% for C: 6.7–5.5; for T: 1.3–8.9; interday CV% for C 6.0–10.8; for T 4.1–10.2) measurements of C-T over a wide concentration range (0.2–200.0 mg/L for C and 0.1–100.0 mg/L for T). Overall, the recovery at quality control concentration levels was high for both C and T (mean values: 90–91 for C and 89–92 for T). Analyte stability was satisfactory in both human plasma and extracts under various storage conditions. The clinical applicability of the assay was confirmed by the reliably quantifying C and T in clinical plasma samples.

Conclusions:
The developed and validated LC-MS/MS method is sensitive and suitable for monitoring C and T in human plasma microsamples.
An Update on the Independent Plastic Surgery Match (2019–2022): Trends, Predictors, and Program Leaders’ Perspectives
Authors: Amro Chris , Ryan Isabel A. , McGraw J. Reed , Broach Robyn B. , Kovach Stephen J. , Serletti Joseph M. , Butler Paris D. , Janis Jeffrey E. , Azoury Saïd C. 
Published: August 2024

Background:
A previous study by the authors noted a decline in independent plastic surgery residency programs and rising applicant participation. This study provides updates on match trends and influential predictors, and gathers program leaders’ views on the future of the independent track.

Methods:
Match data (2019–2022) were obtained from the San Francisco match after American Council of Educators in Plastic Surgery approval. Variables influencing match success were analyzed, and program leaders were surveyed about desirable applicant traits and program trajectories.

Results:
From 2019 to 2022, 243 of 428 applicants matched. Programs and positions declined by 10% and 9.5%, respectively. Applicants rose to 42.3%, but match rates fell from 82% to 56%. Osteopathic graduates doubled, whereas international graduates increased to 53.8%. Successful matches were associated with US allopathic medical school graduates, university-affiliated general surgery residencies, eight or more interviews, United States Medical Licensing Examination scores greater than 230, and high post graduate year (PGY)1–3 American Board of Surgery In-service Training Examination scores (PGY1–64.7%, PGY2–61.2%, PGY3–60.7%; P < 0.05). Of surveyed programs, 55.6% aimed to continue running the independent track in the next year. Conversely, 7.4% planned to discontinue in the next year, 22.2% within 2–5 years, 7.4% within the next decade, and 7.4% were unsure.

Conclusions:
Although support for the independent plastic surgery track remains, program participation diminishes as applicant interest increases, intensifying match challenges. Increasing number of interviews improves match potential. Program leaders display varied commitments, with looming plans for some programs to discontinue offering this track. Applicant evaluation pivots on strong recommendations, research, and test scores.
Management of Perifoveal Exudative Vascular Anomalous Complex
Authors: Savastano Maria Cristina , Fossataro Claudia , Gravina Gianni , Coccimiglio Francesca , Rizzo Clara , Rizzo Stanislao 
Published: August 2024

Purpose:
To report a case of a patient with perifoveal exudative vascular anomalous complex (PEVAC) and to analyze morphological and vascular changes by OCT and OCTA before and after treatment.

Materials and Methods:
In this case we reported a case which received multiple treatment for unresponsive effect to Repeated Aflibercept intravitreal injections, subthreshold micropulse laser therapy (SMPL) duty cycle 5%. At last the focal fully dose yellow laser was performed.

Results:
A 57-year-old male patient presented with best corrected visual acuity (BCVA) of 20/50 in his right eye (RE) The fundoscopic evaluation, structural optical coherence tomography (OCT) and OCT angiography (OCTA) deposed for a diagnosis of PEVAC. The patient underwent three Aflibercept intravitreal injections in the RE. Since no changes were detected, we opted for multiple sessions of yellow subthreshold micropulse laser therapy (SMPL) duty cycle 5%, however no signs of regression were registered. Only after a fully dose yellow laser, signs of edema regression were observed. Stuctural OCT B-scan showed complete restitutio of retinal profile, in absence of any intraretinal or subretinal fluid and PEVAC lesion, while the OCTA showed a slight flow deficit at the previous lesion site.

Conclusions
and Importance: The PEVAC treatment is still unknown. In our experience, we reported a case of multiple treatments for unresponsive effect to: Aflibercept intravitreal injections, subthreshold micropulse laser therapy (SMPL) duty cycle 5%. At list the focal fully dose yellow laser was the only effective in our patient. We proposed our management to share the heterogeneous response at PEVAC entity.
Is personalization of psychological pain treatments necessary? Evidence from a Bayesian variance ratio meta-analysis
Authors: Scholten Saskia , Herzog Philipp , Glombiewski Julia Anna , Kaiser Tim 
Published: August 2024

Abstract
This is the first study to empirically determine the potential for data-driven personalization in the context of chronic primary pain (CPP). Effect sizes of psychological treatments for individuals with CPP are small to moderate on average. Aiming for better treatment outcomes for the individual patient, the call to personalize CPP treatment increased over time. However, empirical evidence that personalization of psychological treatments can optimize treatment outcomes in CPP is needed. This study seeks to estimate heterogeneity of treatment effect for cognitive behavioral therapy (CBT) as the psychological treatment approach for CPP with the greatest evidence base. For this purpose, a Bayesian variance ratio meta-regression is conducted using updated data from 2 recently published meta-analyses with randomized controlled trials comparing CBT delivered face-to-face to treatment-as-usual or waiting list controls. Heterogeneity in patients with CPP would be reflected by a larger overall variance in the post-treatment score compared with the control group. We found first evidence for an individual treatment effect in CBT compared with the control group. The estimate for the intercept was 0.06, indicating a 6% higher variance of end point values in the intervention groups. However, this result warrants careful consideration. Further research is needed to shed light on the heterogeneity of psychological treatment studies and thus to uncover the full potential of data-driven personalized psychotherapy for patients with CPP.
A Bayesian variance ratio meta-regression indicates empirical evidence that data-driven personalized psychotherapy for patients with chronic primary pain could increase effects of cognitive behavioral therapy.
Surgical Treatment for Provoked Vulvodynia: A Systematic Review
Authors: Saçıntı Koray Görkem , Razeghian Hosna , Bornstein Jacob 
Published: August 2024

Objective
Provoked vulvodynia (PV), characterized by vulvar pain upon touch or pressure, is the leading cause of pain during sexual intercourse. It causes a significant decline in overall quality of life, including sexual dysfunction and mental distress. Surgical interventions, such as perineoplasty and vestibulectomy, are considered a last resort for PV cases unresponsive to less invasive therapies. This systematic review evaluates the efficacy of surgery for PV and suggests areas for future research.

Materials and Methods
The literature search encompassed PubMed, Scopus, Web of Science, and Cochrane Library, identifying relevant peer-reviewed studies up to August 21, 2023.

Results
Out of 1102 records retrieved, 29 met the eligibility criteria. Surgery was typically considered after failed conservative treatments. In 15 of the 29 studies defining surgical success as a significant reduction in dyspareunia, success rates ranged from 52% to 93%. Six studies using validated scales for pain assessment noted a significant reduction in vulvar pain following surgery (p < .001). Two studies reported enhancements in sexual function ranging from 57% to 87%, while 3 studies found 89%–97% of women regained the ability to engage in sexual intercourse after surgery. Patient satisfaction rates ranged from 79% to 93%. Bartholin cysts occurred in up to 9% of cases, the most common complication reported.

Conclusion
Surgery seems to be an effective and safe PV treatment option with success rates ranging from 52% to 97%, depending on the variation of outcome measures. Randomized clinical trials with established outcome measures are needed to determine the best surgical approach with minimal operative risk and optimal long-term outcomes.
Airway Anomalies in Pediatric Patients After Surgery for Congenital Heart Disease: Single-Center Retrospective Cohort Study, Taiwan, 2017–2020*
Authors: Wu Jeng-Hung , Wu En-Ting , Chou Heng-Wen , Wang Ching-Chia , Lu Frank Leigh , Wang Yi-Chia , Huang Chi-Hisang , Chen Shyh-Jye , Chen Yih-Sharng , Huang Shu-Chien 
Published: August 2024

OBJECTIVES:
Airway anomalies increase risk of morbidity and mortality in postoperative pediatric patients with congenital heart disease (CHD). We aimed to identify airway anomalies and the association with intermediate outcomes in patients undergoing surgery for CHD.

DESIGN:
Single-center, hospital-based retrospective study in Taiwan, 2017–2020.

SETTING:
A tertiary referral hospital in Taiwan.

PATIENTS:
All pediatric patients who underwent surgery for CHD and were admitted to the PICU and had data about airway evaluation by cardiopulmonary CT scan or bronchoscopy.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
Among 820 CHD patients identified as having undergone airway evaluation in the PICU, 185 (22.6%) were diagnosed with airway anomalies, including structural lesions in 146 of 185 (78.9%), and dynamic problems were seen in 87 of 185 (47.0%). In this population, the explanatory factors associated with greater odds (odds ratio [OR]) of airway anomaly were premature birth (OR, 1.90; p = 0.002), genetic syndromes (OR, 2.60; p < 0.001), and in those with preoperative ventilator use (OR, 4.28; p < 0.001). In comparison to those without airway anomalies, the presence of airway anomalies was associated with higher hospital mortality (11.4% vs. 2.7%; p < 0.001), prolonged intubation days (8 d [1–27 d] vs. 1 d [1–5 d]; p < 0.001), longer PICU length of stay (23 d [8–81 d] vs. 7 d [4–18 d]; p < 0.001), and greater hazard of intermediate mortality (adjusted hazard ratio, 2.60; p = 0.001).

CONCLUSIONS:
In our single-center retrospective study, 2017–2020, between one-in-five and one-in-four of our postoperative CHD patients undergoing an airway evaluation had airway anomalies. Factors associated with greater odds of airway anomaly included, those with premature birth, or genetic syndromes, and preoperative ventilator use. Overall, in patients undergoing airway evaluation, the finding of an airway anomalies was associated with longer postoperative intubation duration and greater hazard of intermediate mortality.