bluuebunny/crossref_metadata_2025_split huggingface dataset:
A meta-analysis of effectiveness studies on computer technology-supported language learning
Authors: Grgurović Maja , Chapelle Carol A. , Shelley Mack C. 
Published: March 2013

AbstractWith the aim of summarizing years of research comparing pedagogies for second/foreign language teaching supported with computer technology and pedagogy not-supported by computer technology, a meta-analysis was conducted of empirical research investigating language outcomes. Thirty-seven studies yielding 52 effect sizes were included, following a search of literature from 1970 to 2006 and screening of studies based on stated criteria. The differences in research designs required subdivision of studies, but overall results favored the technology-supported pedagogy, with a small, but positive and statistically significant effect size. Second/foreign language instruction supported by computer technology was found to be at least as effective as instruction without technology, and in studies using rigorous research designs the CALL groups outperformed the non-CALL groups. The analyses of instructional conditions, characteristics of participants, and conditions of the research design did not provide reliable results because of the small number of effect sizes representing each group. The meta-analysis results provide an empirically-based response to the questions of whether or not technology-supported pedagogies enhance language learning, and the process of conducting the meta-analysis pointed to areas in research methodology that would benefit from attention in future research.
Impact of the Christchurch Earthquakes on Hospital Staff
Authors: Tovaranonte Pleayo , Cawood Tom J. 
Published: March 2013

AbstractIntroductionOn September 4, 2010 a major earthquake caused widespread damage, but no loss of life, to Christchurch city and surrounding areas. There were numerous aftershocks, including on February 22, 2011 which, in contrast, caused substantial loss of life and major damage to the city. The research aim was to assess how these two earthquakes affected the staff in the General Medicine Department at Christchurch Hospital.ProblemTo date there have been no published data assessing the impact of this type of natural disaster on hospital staff in Australasia.MethodsA questionnaire that examined seven domains (demographics, personal impact, psychological impact, emotional impact, impact on care for patients, work impact, and coping strategies) was handed out to General Medicine staff and students nine days after the September 2010 earthquake and 14 days after the February 2011 earthquake.ResultsResponse rates were ≥ 99%. Sixty percent of responders were <30 years of age, and approximately 60% were female. Families of eight percent and 35% had to move to another place due to the September and February earthquakes, respectively. A fifth to a third of people had to find an alternative route of transport to get to work but only eight percent to 18% took time off work. Financial impact was more severe following the February earthquake, with 46% reporting damage of >NZ $1,000, compared with 15% following the September earthquake (P < .001). Significantly more people felt upset about the situation following the February earthquake than the September earthquake (42% vs 69%, P < .001). Almost a quarter thought that quality of patient care was affected in some way following the September earthquake but this rose to 53% after the February earthquake (12/53 vs 45/85, P < .001). Half believed that discharges were delayed following the September earthquake but this dropped significantly to 15% following the February earthquake (27/53 vs 13/62, P < .001).ConclusionThis survey provides a measure of the result of two major but contrasting Christchurch earthquakes upon General Medicine hospital staff. The effect was widespread with minor financial impact during the first but much more during the second earthquake. Moderate psychological impact was experienced in both earthquakes. This data may be useful to help prepare plans for future natural disasters.TovaranonteP, CawoodTJ. Impact of the Christchurch earthquakes on hospital staff. Prehosp Disaster Med. 2013;28(3):1-6.
The folate status of reproductive-aged women in a randomised trial of a folate-fortified oral contraceptive: dietary and blood assessments
Authors: Castaño Paula M , Aydemir Aida , Sampson-Landers Carole , Lynen Richard 
Published: March 2013

AbstractObjectiveTo assess the folate status of US women in a study of a folate-fortified oral contraceptive (OC) using the Short Folate Food Frequency Questionnaire and plasma and red blood cell (RBC) folate samples.DesignSub-analysis from a multi-centre, randomised, double-blind, controlled contraceptive trial with assessments at baseline and 6 months. We calculated dietary folate equivalents (DFE) consumed and the proportion of participants meeting folate adequacy benchmarks.SettingEight centres in the USA.SubjectsHealthy women aged 18–40 years requesting contraception with no contraindications for OC use.ResultsOverall, 385 participants were randomised to either a novel folate-fortified OC or a marketed OC. The 262 (68 %) participants compliant with the protocol were included in the analysis set. Baseline daily DFE consumption was 529·8 (sd 342·1) μg and similar in both groups. At follow-up, the fortified OC group had higher intake than the conventional OC group (1225·9 (sd 346·2) μg compared with 500·6 (sd 361·2) μg). Mean plasma folate level increased from 44·5 (sd 17·2) to 55·8 (sd 21·1) nmol/l. Mean RBC folate level increased from 996·7 (sd 369·8) to 1311·9 (sd 436·0) nmol/l. The proportion meeting selected folate adequacy benchmarks increased in the fortified OC group (P < 0·001).ConclusionsLack of adequate folate intake in reproductive-aged women from dietary sources or supplements alone suggests the need for novel approaches. Use of folate-fortified OC ensures adequate folate levels and meeting of folate benchmarks.
Composing Individuals: Ethnographic Reflections on Success and Prestige in the British New Music Network
Authors: MALCOMSON HETTIE 
Published: March 2013

AbstractIn contrast to established musicians, lesser-known composers have received scant attention in art music scholarship. This article, based on an ethnographic study, considers how a group of British composers construed ideas of success and prestige, which I analyse in terms of anthropological writings on exchange, Bourdieusian symbolic economies, and Foucauldian notions of disciplinary power. Prestige was ascribed to composers who created ‘interesting’ music, a category that eclipsed novelty as an aim. Individuality, enacted within a context of individualism, was key to assessing whether music was interesting. This individuality had to be tempered, structured, and embedded in the social norms of this and related ‘art worlds’. The article examines the social processes involved in creating this individuality, musical personality, and music considered interesting.
Nitrogen mineralisation dynamics of meat bone meal and cattle manure as affected by the application of softwood chip biochar in soil
Authors: Tammeorg Priit , Brandstaka Tero , Simojoki Asko , Helenius Juha 
Published: March 2013

ABSTRACTWe studied the impact of added biochar on the N mineralisation dynamics of two organic fertilisers by incubating loamy sand soil for 133 days in controlled conditions. Biochar made from softwood chips was added to soil at 0, 4·6, 9·1 and 13·6 g kg–1soil dry matter (DM) either alone, or in combination with meat bone meal (MBM) and composted cattle manure (CCM) fertilisers. Soil mineral N concentration was determined on days 0, 14, 28, 56, 84 and 133. Net N mineralisation in the MBM treatment was much larger than in the CCM or the unfertilised treatments. Constant soil moisture during the incubation provided suitable aerobic soil conditions for nitrification: after day 14, soil mineral N was dominated by nitrate in all treatments. Biochar additions decreased the mineral N concentrations in all treatments, probably because of immobilisation by microbes. In unfertilised soil, the immobilisation by biochar increased steadily with application rate and time, but in the MBM and CCM treatments, it started to decrease or level off after two months, possibly due to the turnover of microbial biomass. The main biochar-induced impacts on soil N mineralisation dynamics could be modelled by using standard and confined exponential models.
Metasignatures Identify Two Major Subtypes of Breast Cancer
Authors: Duan Q , Kou Y , Clark NR , Gordonov S , Ma'ayan A 
Published: March 2013

Genome‐wide expression data from tumors and cell lines in breast cancer, together with drug response of cell lines, open prospects for integrative analyses that can lead to better personalized therapy. Drug responses and expression data collected from cell lines and tumors were used to generate tripartite networks connecting clusters of patients to cell lines and cell lines to drugs, to connect drugs to patients. Various approaches were applied to connect cell lines to tumor clusters: a standard method that uses a biomarker gene set, and new methods that compute metasignatures for transcription factors and histone modifications given upregulated genes in cell lines or tumors. The results from the metasignature analysis identify two major clusters of patients: one enriched for active histone marks and one for repressive marks. The tumors enriched for activation marks are correlated with poor prognosis. Overall, the analyses suggest new patient clustering, discover dysregulated pathways, and recommend individualized use of drugs to treat subsets of patients.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e35; doi:10.1038/psp.2013.11; advance online publication 27 March 2013
Compressive adaptive computational ghost imaging
Authors: Aβmann Marc , Bayer Manfred 
Published: March 2013

AbstractCompressive sensing is considered a huge breakthrough in signal acquisition. It allows recording an image consisting of N2 pixels using much fewer than N2 measurements if it can be transformed to a basis where most pixels take on negligibly small values. Standard compressive sensing techniques suffer from the computational overhead needed to reconstruct an image with typical computation times between hours and days and are thus not optimal for applications in physics and spectroscopy. We demonstrate an adaptive compressive sampling technique that performs measurements directly in a sparse basis. It needs much fewer than N2 measurements without any computational overhead, so the result is available instantly.
Interchangeable adaptors regulate mitochondrial dynamin assembly for membrane scission
Authors: Koirala Sajjan , Guo Qian , Kalia Raghav , Bui Huyen T. , Eckert Debra M. , Frost Adam , Shaw Janet M. 
Published: March 2013

Significance
Mitochondrial fission is critical for mammalian cell division, mitophagy, and development. Fission initiates via recruitment of dynamin-related GTPases to the mitochondrial surface. In yeast and human, the recruitment utilizes adaptors that differ in sequence and predicted structure. Key unresolved issues are whether these adaptors function independently in membrane recruitment and whether a single adaptor and GTPase are sufficient to catalyze scission. We show that three human adaptors work interchangeably with a single mitochondrial dynamin to accomplish fission. We also show that an adaptor alters the architecture of the dynamin polymer in a manner that could facilitate membrane constriction and severing.
First Report of Branch Dieback of Walnut Caused by Neofusicoccum parvum in Korea
Authors: Cheon W. , Kim Y. S. , Lee S. G. , Jeon Y. H. , Chun I.-J. 
Published: March 2013

Walnut (Juglans sinensis Dode) is an economically important tree in the world, both for its wood and its fruit. Walnut fruits, as rich sources of omega-3 essential fatty acid, are valuable nutritionally. Consumer interest in Korea for walnuts has increased in recent years, and production has increased to 1,042 ha with the Kyoungbuk region consisting of 402 ha (2). In May 2012, lethal dieback disease of walnut tree was detected in two orchards in Andong, Kyoungbuk region, Korea, each with an incidence of 25 to 30%. Disease symptoms included blight and dieback of the stems, flowing resin, dark decay inside the bark of dead twigs, and defoliation. The bark of dead twigs was removed and sliced thinly using a razor blade, and water-mounted, without staining, for observation of fungal structures, if present. Pycnidia were found embedded within the bark of dead twigs and conidia were mostly characterized by fusoid, hyaline, smooth, thin-walled, unicellular and 16.25 to 21.25 μm long and 4.37 to 6.87 μm wide. These characteristics are consistent with those reported previously for Neofusicoccum parvum (Pennycook & Samuels) Crous, Slippers & A.J.L. Phillips (1). Diseased branch tissues collected from the two locations were surface sterilized with 1% NaOCl, rinsed with sterile distilled water, and plated on potato dextrose agar (PDA). The fungal isolates, recovered from the two different orchards, produced white, aerial mycelium and became light gray within a week after incubating plates at 25°C. To confirm the identities of the isolates, the complete internal transcribed spacer (ITS) rDNA of the fungi was amplified and sequenced using PCR. The sequences were compared with other DNA sequences in the GenBank database, using a BLAST search. BLAST analysis of the PCR product showed that the sequence had 99% identity with the nucleotide sequences for N. parvum (JQ411396.1 and GU997688.1). Additionally, the chitin synthase 1 gene was sequenced and analyzed using the BLAST server. The sequence of PCR product had 100% identity with the nucleotide sequences of N. parvum strain CMW9080 chitin synthase 1 gene (EU339501). Thus, both morphological and molecular characters confirmed this species as N. parvum. Pathogenecity tests were performed by inoculating 2-year-old J. sinensis trees. Inoculations consisted of inserting 5-mm-diamter agar plug bearing fresh mycelium of the fungal isolates into the wounds. Within 2 weeks, black lesions appeared on all inoculated plants accompanied by defoliation, whereas no symptoms were observed in the control plants. N. parvum has been reported a member of Botryosphaeriaceae, commonly associated with dieback and cankers of woody plants (1). To our knowledge, this study is the first report of N. parvum as a pathogen of Juglans sinensis in Korea. References: (1) P. W. Crous et al. Stud. Mycol. 55:235, 2006. (2) Statistics Korea. Forest Households by Growing Area of Walnut/Total Area. 2010.
Low-frequency Neuromuscular Depression Is a Consequence of a Reduction in Nerve Terminal Ca2+ Currents at Mammalian Motor Nerve Endings
Authors: Silinsky Eugene M. 
Published: March 2013

Abstract

Background:
The decline in voluntary muscle contraction during low-frequency nerve stimulation is used clinically to assess the type and degree of neuromuscular block. The mechanism underlying this depression is unknown.

Methods:
Simultaneous electrophysiological measurements of neurotransmitter release and prejunctional Ca2+ currents were made at mouse neuromuscular junctions to evaluate the hypothesis that decreases in nerve terminal Ca2+ currents are responsible for low-frequency depression.

Results:
Under conditions generally used to measure Ca2+ currents at the neuromuscular junction, increasing the frequency of nerve stimulation briefly from 0.017 to 0.1–1 Hz caused a simultaneous reduction in the release of the neurotransmitter acetylcholine to 52.2 ± 4.4% of control and the Ca2+ current peak to 75.4 ± 2.0% of control (P < 0.001, n = 5 experiments for both measurements, mean ± SEM for all data). In conditions used for train-of-four monitoring (4 stimuli, 2 Hz), neurotransmitter release declined to 42.0 ± 1.0% of control and the Ca2+ current peak declined to 75.8 ± 3.3% of control between the first and fourth stimulus (P < 0.001, n = 7 experiments for both measurements). Depression in acetylcholine release during train-of-four protocols also occurred in the absence of neuromuscular-blocking drugs.

Discussion:
The results demonstrate that neuromuscular depression during train-of-four monitoring is due to a decline in nerve terminal Ca2+ currents, hence reducing the release of acetylcholine. As similar processes may come into play at higher stimulation frequencies, agents that antagonize the decline in Ca2+ currents could be used to treat conditions in which neuromuscular depression can be debilitating.
Regulation of Arabidopsis Leaf Hydraulics Involves Light-Dependent Phosphorylation of Aquaporins in Veins
Authors: Prado Karine , Boursiac Yann , Tournaire-Roux Colette , Monneuse Jean-Marc , Postaire Olivier , Da Ines Olivier , Schäffner Anton R. , Hem Sonia , Santoni Véronique , Maurel Christophe 
Published: March 2013

Abstract
The water status of plant leaves depends on the efficiency of the water supply, from the vasculature to inner tissues. This process is under hormonal and environmental regulation and involves aquaporin water channels. In Arabidopsis thaliana, the rosette hydraulic conductivity (K ros) is higher in darkness than it is during the day. Knockout plants showed that three plasma membrane intrinsic proteins (PIPs) sharing expression in veins (PIP1;2, PIP2;1, and PIP2;6) contribute to rosette water transport, and PIP2;1 can fully account for K ros responsiveness to darkness. Directed expression of PIP2;1 in veins of a pip2;1 mutant was sufficient to restore K ros. In addition, a positive correlation, in both wild-type and PIP2;1-overexpressing plants, was found between K ros and the osmotic water permeability of protoplasts from the veins but not from the mesophyll. Thus, living cells in veins form a major hydraulic resistance in leaves. Quantitative proteomic analyses showed that light-dependent regulation of K ros is linked to diphosphorylation of PIP2;1 at Ser-280 and Ser-283. Expression in pip2;1 of phosphomimetic and phosphorylation-deficient forms of PIP2;1 demonstrated that phosphorylation at these two sites is necessary for K ros enhancement under darkness. These findings establish how regulation of a single aquaporin isoform in leaf veins critically determines leaf hydraulics.
Modularity of Plant Metabolic Gene Clusters: A Trio of Linked Genes That Are Collectively Required for Acylation of Triterpenes in Oat
Authors: Mugford Sam T. , Louveau Thomas , Melton Rachel , Qi Xiaoquan , Bakht Saleha , Hill Lionel , Tsurushima Tetsu , Honkanen Suvi , Rosser Susan J. , Lomonossoff George P. , Osbourn Anne 
Published: March 2013

AbstractOperon-like gene clusters are an emerging phenomenon in the field of plant natural products. The genes encoding some of the best-characterized plant secondary metabolite biosynthetic pathways are scattered across plant genomes. However, an increasing number of gene clusters encoding the synthesis of diverse natural products have recently been reported in plant genomes. These clusters have arisen through the neo-functionalization and relocation of existing genes within the genome, and not by horizontal gene transfer from microbes. The reasons for clustering are not yet clear, although this form of gene organization is likely to facilitate co-inheritance and co-regulation. Oats (Avena spp) synthesize antimicrobial triterpenoids (avenacins) that provide protection against disease. The synthesis of these compounds is encoded by a gene cluster. Here we show that a module of three adjacent genes within the wider biosynthetic gene cluster is required for avenacin acylation. Through the characterization of these genes and their encoded proteins we present a model of the subcellular organization of triterpenoid biosynthesis.
European consumer perceptions and barriers for fresh, frozen, preserved and ready‐meal fish products
Authors: Vanhonacker Filiep , Pieniak Zuzanna , Verbeke Wim 
Published: March 2013

PurposeThis study aims to investigate consumers' perceptions and barriers in relation to fresh, frozen, preserved and ready‐meal fish products in a geographically diverse selection of European countries.Design/methodology/approachCross‐sectional data were collected through a consumer survey (n=3,213), conducted in June 2008 in the Czech Republic, Germany, Greece, Italy, Portugal, Romania, Sweden and the UK. Items measured were self‐reported consumption frequencies, consumer perceptions of different fish product categories, and perceived barriers for increased fish consumption levels. Country specificities are discussed.FindingsThe overriding healthy perception consumers have about fish was confirmed, and contributed very strongly to the general perception consumers have about fish. Fresh fish was perceived the most healthy fish product, followed by frozen, preserved and ready‐meal fish products. Perception scores were highest correlated with self‐reported fish consumption in the Mediterranean countries. With the exception of Romania, perceived barriers only poorly explained self‐reported consumption frequencies of the different fish product categories. This finding is related to the possible influence of habit and tradition with regard to eating fish, to the absence of measures related to motivations or drivers to consume fish, or to the possibility that some of the perceived barriers reinforce each other. In the Mediterranean countries, fish consumption frequency is on a very high level, independently of perceived barriers and motivational aspects, and part of the traditional Mediterranean diet.Originality/valueThe strength of this study pertains to its international scope and geographical spread. Further, consumer perceptions and perceived barriers in relation to fresh, frozen, preserved and ready‐meal fish products have rarely been studied in parallel. Findings are relevant to support efforts on national and international level to stimulate or modify fish consumption, and to explore opportunities to trade fish products.
Consumers' health and taste attitude in Taiwan
Authors: Chen Mei‐Fang 
Published: March 2013

PurposePrevious studies indicate that both health and taste are important factors in the food choice process. Owing to the industrialization of food processing and biotechnological innovations on the one hand and a series of food scandals on the other, consumers are now more concerned about modern food hazards. The present study aims to investigate whether consumers with varying degrees of modern tainted foods worries and gender difference will show variations in the Health and Taste Attitude Scales (HTAS).Design/methodology/approachOf a total of 1,500 questionnaires sent out, 533 were found useful for this empirical analysis. The measurement items of the Health and Taste Attitude Scale (HTAS) were scored as the data input to test for the impacts of modern tainted foods worries and gender by ANOVA tests.FindingsThe results of this study conducted in Taiwan indicate that those people identified in the ‘‘high modern tainted foods worries’’ group have more interests in health in foods but the ‘‘low modern tainted foods worries’’ group have more interests in taste in foods. In addition, though more concerned about health in foods, female consumers are also more interested in sweet foods.Practical implicationsSome suggestions for food marketers and food policy makers are also provided in this study.Originality/valueTo the best knowledge of this researcher, this study represents one of the first attempts to investigate the health and taste attitudes in Taiwan and tests for the impacts of modern tainted foods worries and gender.