bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoptosis signal-regulating kinase 1 is associated with the effect of claudin-6 in breast cancer
Authors: Guo Yaxiong , Xu Xiaoming , Liu Zhijing , Zhang Ting , Zhang Xiaowei , Wang Liping , Wang Min , Liu Yuanyuan , Lu Yan , Liu Yunpeng , Quan Chengshi 
Published: August 2012

Abstract

Background
Previous studies have demonstrated that claudin-6 functions as a cancer suppressor in human MCF-7 breast cancer cells. The growth inhibitory effect could be attributed to inhibition of cell proliferation and induction of apoptosis. The purpose of the current study was to examine the involvement of apoptosis signal-regulating kinase 1 (ASK1) in the anticancer effect of claudin-6.

Methods
Immunohistochemical analysis was performed to evaluate the ASK1 protein expression and the correlation between ASK1, claudin-6 and clinicopathological features in 85 samples of breast invasive ductal carcinomas (IDC). Western blotting and RT-PCR was carried out to examine the expression of ASK1 and claudin-6 in MCF-7 cell clones transfected with claudin-6.

Results
Immunohistochemical analysis showed that ASK1 expression was significantly related with that of claudin-6 in breast invasive ductal carcinomas (
P
< 0.05). In addition, a positive correlation between ASK1 and C-erb B 2 protein expression was identified (
P
< 0.05). Western blotting and RT-PCR consistently revealed that the level of ASK1 protein and mRNA was upregulated in MCF-7 cell clones transfected with claudin-6.

Conclusions
Our data suggests, for the first time, that the ASK1 signal may play a positive role in the inhibitory effect of claudin-6 in breast cancer.

Virtual Slides
The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1200314318763661
Canine mesenchymal stem cells are effectively labeled with silica nanoparticles and unambiguously visualized in highly autofluorescent tissues
Authors: Han Sei-Myoung , Lee Hee-Woo , Bhang Dong-Ha , Seo Kyoung-Won , Youn Hwa-Young 
Published: August 2012

Abstract

Background
Development of a method for long-term labeling of cells is critical to elucidate transplanted cell fate and migration as well as the contribution to tissue regeneration. Silica nanoparticles have been recently developed and demonstrated to be biocompatible with a high labeling capacity. Thus, our study was designed to assess the suitability of silica nanoparticles for labeling canine mesenchymal stem cells (MSCs) and the fluorescence afficiency in highly autofluorescent tissue.

Results
We examined the effect of silica nanoparticle labeling on stem cell morphology, viability and differentiation as compared with those of unlabeled control cells. After 4 h of incubation with silica nanoparticles, they were internalized by canine MSCs without a change in the morphology of cells compared with that of control cells. The viability and proliferation of MSCs labeled with silica nanoparticles were evaluated by a WST-1 assay and trypan blue exclusion. No effects on cell viability were observed, and the proliferation of canine MSCs was not inhibited during culture with silica nanoparticles. Furthermore, adipogenic and osteogenic differentiation of silica nanoparticle-labeled canine MSCs was at a similar level compared with that of unlabeled cells, indicating that silica nanoparticle labeling did not alter the differentiation capacity of canine MSCs. Silica nanoparticle-labeled canine MSCs were injected into the kidneys of BALB/c mice after celiotomy, and then the mice were sacrificed after 2 or 3 weeks. The localization of injected MSCs was closely examined in highly autofluorescent renal tissues. Histologically, canine MSCs were uniformly and completely labeled with silica nanoparticles, and were unambiguously imaged in histological sections.

Conclusions
The results of the current study showed that silica nanoparticles are useful as an effective labeling marker for MSCs, which can elucidate the distribution and fate of transplanted MSCs.
Left pulmonary artery banding to repair ipsilateral diffuse pulmonary arteriovenous fistula
Authors: Hirata Takuya , Akagi Kentaro , Baba Shiro , Tsurumi Fumitoshi , Nakata Tomohiro , Ikeda Tadashi , Doi Hiraku 
Published: August 2012

Abstract
Congenital pulmonary arteriovenous fistula (PAVF) is a rare disease which causes hypoxemia by shunting deoxygenated blood from the pulmonary artery into pulmonary venous return. Lung transplantation is the most effective therapy to treat severe, diffuse PAVF. However, the availability of lungs for transplantation is limited in most parts in the world. For patients with diffuse PAVF affecting only one side of the lungs, ipsilateral pulmonary artery banding (PAB) is an effective treatment, but not yet standard of care. We report successful treatment of a patient with diffuse left-sided PAVF with PAB. We believe that PAB is an effective therapy for severe unilateral PAVF and may serve as a bridge to lung transplantation.
Balancing speed and accuracy of polyclonal T cell activation: a role for extracellular feedback
Authors: Savir Yonatan , Waysbort Nir , Antebi Yaron E , Tlusty Tsvi , Friedman Nir 
Published: August 2012

AbstractBackgroundExtracellular feedback is an abundant module of intercellular communication networks, yet a detailed understanding of its role is still lacking. Here, we study interactions between polyclonal activated T cells that are mediated by IL-2 extracellular feedback as a model system.ResultsUsing mathematical modeling we show that extracellular feedback can give rise to opposite outcomes: competition or cooperation between interacting T cells, depending on their relative levels of activation. Furthermore, the outcome of the interaction also depends on the relative timing of activation of the cells. A critical time window exists after which a cell that has been more strongly activated nevertheless cannot exclude an inferior competitor.ConclusionsIn a number of experimental studies of polyclonal T-cell systems, outcomes ranging from cooperation to competition as well as time dependent competition were observed. Our model suggests that extracellular feedback can contribute to these observed behaviors as it translates quantitative differences in T cells’ activation strength and in their relative activation time into qualitatively different outcomes. We propose extracellular feedback as a general mechanism that can balance speed and accuracy – choosing the most suitable responders out of a polyclonal population under the clock of an escalating threat.
Structural confirmation of oligosaccharides newly isolated from sugar beet molasses
Authors: Abe Tatsuya , Horiuchi Kenichi , Kikuchi Hiroto , Aritsuka Tsutomu , Takata Yusuke , Fukushi Eri , Fukushi Yukiharu , Kawabata Jun , Ueno Keiji , Onodera Shuichi , Shiomi Norio 
Published: August 2012

Abstract

Background
Sugar beet molasses is a viscous by-product of the processing of sugar beets into sugar. The molasses is known to contain sucrose and raffinose, a typical trisaccharide, with a well-established structure. Although sugar beet molasses contains various other oligosaccharides as well, the structures of those oligosaccharides have not been examined in detail. The purpose of this study was isolation and structural confirmation of these other oligosaccharides found in sugar beet molasses.

Results
Four oligosaccharides were newly isolated from sugar beet molasses using high-performance liquid chromatography (HPLC) and carbon-Celite column chromatography. Structural confirmation of the saccharides was provided by methylation analysis, matrix-assisted laser desorption/ionaization time of flight mass spectrometry (MALDI-TOF-MS), and nuclear magnetic resonance (NMR) measurements.

Conclusion
The following oligosaccharides were identified in sugar beet molasses: β-D-galactopyranosyl-(1- > 6)-β-D-fructofuranosyl-(2 <-> 1)-α-D-glucopyranoside (named β-planteose), α-D-galactopyranosyl-(1- > 1)-β-D-fructofuranosyl-(2 <-> 1)-α-D-glucopyranoside (named1-planteose), α-D-glucopyranosyl-(1- > 6)-α-D-glucopyranosyl-(1 <-> 2)-β-D-fructofuranoside (theanderose), and β-D-glucopyranosyl-(1- > 3)-α-D-glucopyranosyl-(1 <-> 2)-β-D-fructofuranoside (laminaribiofructose). 1-planteose and laminaribiofructose were isolated from natural sources for the first time.
Molecular markers associated with outcome and metastasis in human pancreatic cancer
Authors: Van den Broeck Anke , Vankelecom Hugo , Van Eijsden Rudy , Govaere Olivier , Topal Baki 
Published: August 2012

AbstractBackgroundPancreatic ductal adenocarcinoma (PDAC) is a heterogeneous cancer in which differences in survival rates might be related to a variety in gene expression profiles. Although the molecular biology of PDAC begins to be revealed, genes or pathways that specifically drive tumour progression or metastasis are not well understood.MethodsWe performed microarray analyses on whole-tumour samples of 2 human PDAC subpopulations with similar clinicopathological features, but extremely distinct survival rates after potentially curative surgery, i.e. good outcome (OS and DFS > 50 months, n = 7)versusbad outcome (OS < 19 months and DFS < 7 months, n = 10). Additionally, liver- and peritoneal metastases were analysed and compared to primary cancer tissue (n = 11).ResultsThe integrin and ephrin receptor families were upregulated in all PDAC samples, irrespective of outcome, supporting an important role of the interaction between pancreatic cancer cells and the surrounding desmoplastic reaction in tumorigenesis and cancer progression. Moreover, some components such asITGB1andEPHA2were upregulated in PDAC samples with a poor outcome, Additionally, overexpression of the non-canonical Wnt/β-catenin pathway and EMT genes in PDAC samples with badversusgood outcome suggests their contribution to the invasiveness of pancreatic cancer, withβ-cateninbeing also highly upregulated in metastatic tissue.ConclusionsComponents of the integrin and ephrin pathways and EMT related genes, might serve as molecular markers in pancreatic cancer as their expression seems to be related with prognosis.
Gene functionalities and genome structure in Bathycoccus prasinos reflect cellular specializations at the base of the green lineage
Authors: Moreau Hervé , Verhelst Bram , Couloux Arnaud , Derelle Evelyne , Rombauts Stephane , Grimsley Nigel , Van Bel Michiel , Poulain Julie , Katinka Michaël , Hohmann-Marriott Martin F , Piganeau Gwenael , Rouzé Pierre , Da Silva Corinne , Wincker Patrick , Van de Peer Yves , Vandepoele Klaas 
Published: August 2012

Abstract
Background
Bathycoccus prasinos is an extremely small cosmopolitan marine green alga whose cells are covered with intricate spider's web patterned scales that develop within the Golgi cisternae before their transport to the cell surface. The objective of this work is to sequence and analyze its genome, and to present a comparative analysis with other known genomes of the green lineage.

Research
Its small genome of 15 Mb consists of 19 chromosomes and lacks transposons. Although 70% of all B. prasinos genes share similarities with other Viridiplantae genes, up to 428 genes were probably acquired by horizontal gene transfer, mainly from other eukaryotes. Two chromosomes, one big and one small, are atypical, an unusual synapomorphic feature within the Mamiellales. Genes on these atypical outlier chromosomes show lower GC content and a significant fraction of putative horizontal gene transfer genes. Whereas the small outlier chromosome lacks colinearity with other Mamiellales and contains many unknown genes without homologs in other species, the big outlier shows a higher intron content, increased expression levels and a unique clustering pattern of housekeeping functionalities. Four gene families are highly expanded in B. prasinos, including sialyltransferases, sialidases, ankyrin repeats and zinc ion-binding genes, and we hypothesize that these genes are associated with the process of scale biogenesis.

Conclusion
The minimal genomes of the Mamiellophyceae provide a baseline for evolutionary and functional analyses of metabolic processes in green plants.
Multiscale matched-field processing for noise-source localization in exploration geophysics
Authors: Corciulo Margherita , Roux Philippe , Campillo Michel , Dubucq Dominique , Kuperman W. A. 
Published: August 2012

In the study, we investigate the use of ambient-noise data to locate microseismic sources at the exploration scale. We develop a multiscale matched-field processing (MFP) approach to localize seismic sources at frequencies below 10 Hz. An application to an actual data set acquired over a hydrocarbon field is presented to determine the reliability of the MFP procedure. The data used were continuously recorded over five days, at a total of 397 stations on a 1-km-per-side square seismic network. The MFP results show: (1) a dominant and stable surface source associated with human activities (road and exploration platforms) around the reservoir; and (2) weaker sources at depth below the seismic network that are related to the injection/extraction process.
Book Reviews
Authors: Dennis Rob , Patti Lisa , Roe Bella Honess 
Published: August 2012

Indie: An American Film Culture, Michael Z. Newman, (2011) New York: Columbia University Press, 304pp., ISBN: 978-0-231-14465-0 (pbk), £18.50, ISBN: 978-0- 231-14464-3 (hbk), £55.00
World Cinemas, Transnational Perspectives, Nataša Durovicová and Kathleen
Newman (eds), (2010) New York: Routledge, 384 pp., ISBN: 9780415976541 (pbk), $37.95
100 Documentary Films, Barry Keith Grant and Jim Hillier, (2009) London: BFI, 266pp., ISBN: 978-1-844572649 (pbk), £12.99
Book Reviews
Authors: Simonowitz David , Power Timothy , Lamprakos Michele , Marashi Afshin , Steele James , Çakmak Gülru , Mitchell Colin 
Published: August 2012

THE FUNDAMENTALIST CITY? RELIGIOSITY AND THE REMAKING OF URBAN SPACE, NEZAR AL SAYYAD AND MEJGAN MASSOUMI (EDS), (2011) London and New York: Routledge, 316 pp., 17 b/w illus., ISBN 9780415779364, $53.95 (paper)
MANAH. AN OMANI OASIS, AN ARABIAN LEGACY: ARCHITECTURE AND SOCIAL
HISTORY OF AN OMANI SETTLEMENT, S. BANDYOPADHYAY, (2011) Liverpool: Liverpool University Press, 300 pp., 200 colour illus., 150 b/w illus., ISBN 9781846311215, $60.00 (cloth)
LIVING IN HISTORIC CAIRO: PAST AND PRESENT IN AN ISLAMIC CITY, FARHAD DAFTARY, ELIZABETH FERNEA AND AZIM
NANJI ( EDS), (2010) London: Azimuth Editions in association with the Institute for Ismaili Studies and the University of Washington Press, 300 pp., 120 illus., DVD, ISBN 9781898592280, $60.00 (cloth)
BUILDING IRAN: MODERNISM, ARCHITECTURE, AND NATIONAL HERITAGE UNDER THE PAHLAVIS,
TALINN GRIGOR, (2009) New York: Periscope Publishing, 237 pp., 156 colour illus., ISBN 9781934772782, $55.00 (cloth)
HASSAN FATHY AND CONTINUITY IN ISLAMIC ARCHITECTURE: THE BIRTH OF A NEW MODERN, AHMAD HAMID, (2010) Cairo and New York: American University in Cairo Press, 205 pp.,
117 illus., 13 colour plates, ISBN 9789774163418, $39.95 (cloth)
THE POETICS AND POLITICS OF PLACE: OOMAN IS TANBUL AND BRITISH ORIENTALISM, ZEYNEP İNANKUR, REINA LEWIS AND MARY OBERTS (EDS), (2011) Istanbul: Pera Museum Publications, 288 pp., 120 colour illus., ISBN 9780295991108,
$60.00 (cloth)
THE SAFAVID DYNASIC SHRINE: ARCHITECTURE, RELIGION AND POWER IN EARLY MODERN IRAN, KISHWAR RIZVI, (2011) London: I.B. Tauris, 269 pp., 88 b/w illus., ISBN 9781848853546, $84.00 (cloth)
Exhibition Reviews
Authors: Kurd Nadia , Cantone Cleo 
Published: August 2012

'MAGIC SQUARES: THE PATTERNED IMAGINATION OF MUSLIM AFRICA IN CONTEMPORARY CULTURE', TEXTILE MUSEUM OF CANADA, MAY 18-NOVEMBER 20, 2011
'HAJJ: JOURNEY TO THE HEART OF ISLAM', BRITISH MUSEUM, LONDON, JANUARY 26-APRIL 15, 2012
Conference Precis
Authors: Bertram Carel , Jelidi Charlotte 
Published: August 2012

'The Spatial Turn in Middle East Studies: Interdisciplinary Methods and Approaches', Round table at the Annual Meeting of the Middle Studies Association, Washington DC, December 3, 2011
'NORTH AFRICAN CITIESIN THE COLONIAL ERA (NINETEENTH AND TWENTIETH CENTURIES): URBANISM, ARCHITECTURE,
HERITAGE. HISTORIOGRAPHICAL REVISIONS BASED ON THE ARCHIVES', A CONFERENCE SPONSORED BY L'INSTITUT DE RECHERCHE SUR LE MAGHREB CONTEMPORAIN (IRMC), HELD IN SIDI BOU SAïD, TUNISIA, FEBRUARY 10–11, 2012
REVIEWS
Authors: Royal Derek Parker , Abrams Rachel , Lightman Sarah , Murray Chris , Cortsen Rikke Platz , Hague Ian 
Published: August 2012

African-American Classics, Tom Pomplun and Lance Tooks (eds) (2011) Mount Horeb, WI: Eureka Productions, 144 pp., $17.95. Paperback ISBN 9780982563045
The Silence of Our Friends, Mark Long, Jim Demonakos and Nate Powell (2012) New York: First Second, 201 pp., $16.99.
Paperback ISBN 9781596436183
The Graphic Details Symposium, at the Center for Jewish History, New York City, 26 February 2012
Graphic Women: Life Narrative & Contemporary Comics, Hillary L. Chute (2010) New York Chichester, West Sussex: Columbia University Press, 297 pp., £18.50.
Paperback ISBN: 9780231150620
1001 Comics You Must Read Before You Die, Paul Gravett (ed.) (2010) Cassell Illustrated/Quintessence Editions Ltd, 960pp., £20. ISBN: 97884403698
Grant Morrison - Combining the Worlds of Contemporary Comics, Marc Singer (2012) Jackson: University
Press of Mississippi, 323 pp., $25. PaperbackISBN: 9781617031366
First International Conference on Comics and Graphic Novels: Sites of Visual and Textual Innovation, Instituto Franklin-UAH, Alcalá de Henares, Spain, 9–12 November 2011
The Effectiveness of Childbirth Classes for Increasing Self-Efficacy in Women and Support Persons
Authors: Larsen Rachelle , Plog Margaret 
Published: August 2012

PURPOSE: Determine the effectiveness of childbirth classes for increasing self-efficacy on expectant women and support persons.MATERIALS & METHODS: This quasi-experimental study used an 18-question self-efficacy instrument to survey 115 expectant women and 103 support persons prior to and immediately following childbirth classes.RESULTS: Childbirth classes significantly increased self-efficacy scores of both the women (t[82] = 211.059, p < 0.000) and the support person (t[77] = 11.673, p < 0.000). Support persons had significantly higher self-efficacy scores after the childbirth class than the women (t[175] = 22.55, p = 0.012). Type of class attended did not significantly affect self-efficacy. Dealing with labor without pain medication continued to be an area of low self-efficacy for women following childbirth classes. Evaluation of childbirth classes will help educators refine content and methods for delivery of childbirth education. Ultimately, improved patient education will result in greater patient satisfaction and optimal birth outcomes.
Association Between Mode of Birth and Self-Reported Maternal Physical and Psychological Health Problems at 10 Weeks Postpartum
Authors: Fenwick Jennifer , Hauck Yvonne , Schmeid Virginia , Dhaliwal Satvinder , Butt Janice 
Published: August 2012

AIM:To determine the association between mode of birth and physical and psychological health problems reported at 10 weeks postpartum.METHODS:A cross-sectional, self-report survey was completed by 2,699 Western Australian women at 10 weeks postpartum. Information on birth mode and physical and psychological health was sought. Descriptive statistics and frequency distributions were performed to describe the sample. Logistic regression was used to determine the association between mode of birth and the reported number of physical health problems (two or more and three or more) and two psychological health problems.RESULTS:The occurrence of physical health problems for all women were incontinence (11.5%), no bowel control (2.6%), backache (41%), heavy bleeding (14.1%), and excessive fatigue or tiredness (35.7%). A significant association was found between all cesarean sections (elective and emergency) and the number of physical health problems compared to spontaneous vaginal births. Women who had an emergency cesarean were most likely (OR= 3.15, CI = 2.40–4.13,p< 0.0005) to report two or more physical problems, whereas women who had an elective cesarean were more likely (OR= 2.75, CI = 2.08–3.63,p< 0.0005) to report three or more physical problems.Nearly 15% of women reported being unhappy for more than a few days. This was highest in women having an emergency cesarean (16.4%) and lowest in women giving birth spontaneously (13.5%). Some 6.4% of women stated they were constantly reliving negative thoughts of birth and/or labor. Women who had an emergency cesarean were more likely (OR= 3.10, CI = 1.96–4.89,p< 0.0005) to choose this item and they were also more likely (OR= 2.04, CI = 1.01–4.13,p< 0.047) to experience both psychological health items.CONCLUSION:Women’s reports of health problems within the first 10 weeks postpartum are concerning and warrant ongoing attention. The prevalence of health problems was higher in women who had experienced a cesarean. This information on morbidity postbirth is essential for women and their care providers in making informed decisions around available birth options.
Becoming Redundant: Australian Women’s Experiences of Pregnancy After Being Unexpectedly Scheduled for a Medically Necessary Term Elective Cesarean Section
Authors: Bayes Sara , Fenwick Jennifer , Hauck Yvonne 
Published: August 2012

PURPOSE:There is now a comprehensive body of evidence reporting the effects of emergency cesarean section on women’s emotional well-being. How women respond to becoming in need of a medically necessary elective cesarean section, however, has not previously been reported. This article describes and explains how a cohort of Australian women experienced the remainder of the antenatal period following the discovery during pregnancy of a medical reason to book a term elective cesarean section.DESIGN:Grounded theory methodology was used for this study.FINDINGS:Seven categories emerged from data analysis to represent the women’s responses to becoming in need of a medically necessary term elective cesarean section. Four categories describe women’s actions and interactions as they dealt with their lost expectations and their perceived “displacement” from their baby’s birth. The other three categories represent the factors that mediated, or caused, women’s responses.MAIN CONCLUSIONS:This study provides new knowledge about how women experience and respond to an unwanted and unforeseen change in their childbearing journey. The sense of disappointment and loss that is likely to arise for women who must “change track” must be anticipated, recognized, acknowledged, and when possible, forestalled by maternity care professionals.