bluuebunny/crossref_metadata_2025_split huggingface dataset:
No lipiodol, no beads—another transcatheter arterial chemoembolization (TACE) with fine cisplatin powder and porous gelatin particles for TACE‐naïve, multifocal, up‐to‐seven out hepatocellular carcinoma
Authors: Sato Rui , Moriguchi Michihisa , Saiga Atsushi , Asahara Kazuhisa , Aramaki Takeshi 
Published: July 2024

AbstractAimThe Japanese Interventional oncology group (JIVROSG) showed the efficacy and safety of nonselective transarterial chemoembolization (TACE) with fine cisplatin powder (diamminedichloroplatinum; DDP‐H) (65 mg/m2) and porous gelatin particles (DDP‐H TACE) without lipiodol for extensive multifocal hepatocellular carcinoma (HCC). However, there are no studies on this method following the JIVROSG study. Therefore, we aimed to evaluate the efficacy of this new DDP‐H TACE and its effect on liver function.MethodsWe retrospectively reviewed the medical records of TACE‐naïve patients with multifocal HCC (Child‐Pugh class A, up‐to‐seven out, no prior history of systemic therapy) who underwent whole‐liver DDP‐H TACE between January 2006 and December 2019.ResultsSixty patients were included in this study. The median age of the patients was 71 (range, 35–88) years. The median maximum size of tumors was 26 (range, 8–184) mm; 86.7% of patients met the up‐to‐11 criteria out. The overall survival duration was 30.3 months. At the time of initial evaluation (median, 45 days), the overall response rate was 65.0%; the disease control rate was 86.7% based on the modified response evaluation criteria in solid tumors guideline. Although nine patients' liver function had deteriorated to Child‐Pugh class B at initial evaluation, six of them recovered to Child‐Pugh class A. Only three patients (5%) showed permanently impaired liver function.ConclusionsWhole‐liver DDP‐H TACE without lipiodol or beads effectively reduced tumors and preserved liver function.
Soft frontal swelling in a young girl: Diagnostic nuances and surgical management of a rare case of sinus pericranii
Authors: Mokbul Mobin Ibne , Yesmin Farjana , Gupta Pukar , Rahman Aminur , Rana Md. Sumon , Islam Md. Shafiqul 
Published: July 2024

Key Clinical MessageA 17‐year‐old girl with a congenital, painless right forehead swelling obstructing her visual field was diagnosed with sinus pericranii. Radiological imaging confirmed extracalvarial arteriovenous malformation with serpentine vessels and bony erosion. Endovascular surgery was chosen for management, highlighting the necessity of considering SP in differential diagnosis for scalp swellings. Despite its rarity, awareness of it is essential to prevent complications from injury, misdiagnosis, or invasive procedures.
Not all maggots are created equal; not all maggots are therapeutic
Authors: Sherman Ronald A. , Nguyen Albert , Dastpak Vahab , Fonseca‐Muñoz Alicia , Parizad Naser , Siavash Mansour , Yusuf Mustapha Ahmed 
Published: July 2024

Key Clinical MessageMaggots in a wound (“myiasis”) cannot be considered maggot therapy (therapeutic myiasis) unless, at a minimum, the species is known to be safe and effective, and the maggots have been properly disinfected. Documenting treatment details is critical and allows us to determine the cause of problems, if they arise.
Sicca syndrome as complication of COVID‐19 infection: A case report
Authors: Tarcha Raghad , Khalayli Naram , Kudsi Maysoun 
Published: July 2024

Key Clinical MessageSeveral reports of suspected oral and ocular manifestations of coronavirus disease 2019 (COVID‐19) has prompted investigations into ocular signs, symptoms, and transmission (5).11.2% of patients with COV19 infection had ocular symptoms, including ocular pain, conjunctivitis, dry eye, and floaters, meanwhile, many studies had documented oral symptoms such as dry mouth and dysgeusia in these patients. Our case reported a 39‐year‐old male, presented with symptoms of dry mouth and dry eye lasting more than 3 months. The patient had recovered from (PCR‐confirmed) COVID‐19 which lasted 10 days, 4 months ago. The physical examination was normal. Ocular findings include conjunctival hyperemia and superficial punctate keratitis. The anti‐nuclear antibody (ANA) was weekly positive at 1/80. Schirmer test considered positive. He continued on 200 mg/day of hydroxychloroquine, along with tear drops until now with remission. Sicca symptoms may be a sequel of COVID‐19 infection, and physicians should be aware of this sequel. The sequela of this infection is not understood, with limited data in the literature. Future prospective cohort studies are needed to reveal the impact of these features on oral health.
CDK4/6 and aromatase inhibitors as first‐line treatment in metastatic high‐grade neuroendocrine carcinoma of the breast: A case report
Authors: Zouki Dionysia N. , Kardara Vasiliki‐Elpida , Ioannou Stephanie , Arvanitou Eleni , Exarchos Konstantinos , Gkikas Konstantinos , Konstantoudakis Stefanos , Lanitis Sophocles , Benakis Stylianos , Tryfonopoulos Dimitrios 
Published: July 2024

Key Clinical MessageThere is no consensus regarding the therapeutic approach of breast neuroendocrine carcinomas (NECs). As most NECs are hormone receptor positive and HER‐2 negative, we suggest that endocrine‐based strategies may play a leading role. Here, we report a new treatment strategy by incorporating CDK4/6 inhibitors in the therapeutic armamentarium.AbstractPrimary neuroendocrine neoplasms of the breast constitute a rare entity. They are characterized by predominant neuroendocrine differentiation and are further divided into well‐differentiated neuroendocrine tumors and poorly differentiated (high‐grade) neuroendocrine carcinomas (NECs). Regarding their therapeutic approach, there are no standardized guidelines. Herein, we present the first case ever reported, concerning a female patient with de novo metastatic breast NEC who received hormonal therapy, a combination of a CDK4/6 inhibitor palbociclib with letrozole and triptorelin, as first‐line treatment with significant clinical and radiological response. As most NECs are estrogen receptor and/or progesterone receptor positive and HER‐2 negative, we suggest that hormonal therapy may play a leading role even in the first‐line setting. The present report provides a new treatment strategy by incorporating CDK4/6 inhibitors in the therapeutic armamentarium of breast NECs.
Improving Environmental Stress Cracking Resistance of High‐Density Polyethylene Grades by Comonomer Addition and Nanocomposite Approach
Authors: Mansouri AmirMohammad , Ghasemi Hamedani Nona , Zou Chen , Mousavi Saber , Khonakdar Hossein Ali , Bahri‐Laleh Naeimeh , Rodríguez‐Pizarro Montserrat , Brotons‐Rufes Artur , Posada‐Pérez Sergio , Poater Albert 
Published: July 2024

AbstractThe aim of this paper is to determine the effect of polymer density, correlated to the comonomer content, and nanosilica addition on the mechanical and Environmental Stress Cracking Resistance (ESCR) characteristics of high‐density polyethylene (HDPE). In this regard, five HDPE samples with similar Melt Flow Index (MFI) and molar mass but various densities were acquired from a petrochemical plant. Two polymerization reactors work in series and differ only in the amount of 1‐buene comonomer fed to the second reactor. To ascertain the microstructure of the studied samples, GPC and SSA (successive self‐nucleation and annealing) analyses were accomplished. All samples resulted having similar characteristics but slightly various SCB/1000 C=7.26–9.74 (SCB=Short Chain Branching). Consequently, meanwhile studied HDPEs reveal similar notched impact and stress at yield values, the tensile modulus, stress‐at‐break, and elongation‐at‐break tend to demonstrate different results with the SCB content. More significantly, ESCR characteristic varied considerably with SCB/1000 C extent, so that higher amount of SCB acknowledged advanced ESCR. Notably, blending HDPE sample containing higher amount of SCB/1000 C, with 3 wt.% of chemically modified nanosilica enhanced ESCR characteristic by 40 %. DFT (Density Functional Theory) calculations unveiled the role of the comonomer, quantitatively by binding energies and qualitatively by Non Covalent Interaction (NCI) plots.
Purification of Steel Mill Gases under Changing Feed Stock Conditions
Authors: Büker Karsten , von Morstein Olaf , Yildirim Ömer , Daheim Nicolai , Frey Andreas , Voss Christian , Geisbauer Andreas 
Published: July 2024

AbstractThis paper focuses on the operation and results of the gas treatment pilot plant for the purification and conditioning of steel mill gases, a key element of the Carbon2Chem® Technical Center in Duisburg, Germany. Using highly sensitive analytics, it is demonstrated that steel mill gas impurities which are detrimental to downstream catalytic conversion are reduced to single‐digit ppb levels. Strategies for adapting the gas purification process to take account of the transformation of steelmaking towards direct reduction are also discussed.
Selenophosphate Pb2P2Se6 Single Crystals Growth by Chemical Vapor Transport (CVT) Method for Radiation Detection
Authors: Ji Leilei , Yin Ziang , Xiao Bao , Ge Bangzhi , Xu Yadong , Jie Wanqi 
Published: July 2024

AbstractThe heavy metal selenophosphate Pb2P2Se6 emerges as a promising room‐temperature X‐ray/γ‐ray detectors due to its high resistivity, robust radiation‐blocking capability, and outstanding carrier mobility‐lifetime product, etc. However, the high activity of phosphides poses significant impediment to the synthesis and single crystal growth. In this work, we have prepared high‐quality Pb2P2Se6 single crystals with using the chemical vapor transport (CVT) method. The XRD analysis combined with EDS result confirmed the uniform composition of the resulting as‐grown single crystals, while UV‐Vis‐NIR transmittance spectra revealed the bandgap of 1.89 eV. Selected area electron diffraction patterns indicated the crystal belonged to the P21/c(14) space group. Additionally, the Au/Pb2P2Se6/Au device is fabricated, which exhibits a robust X‐ray response with a sensitivity of 648.61 μC Gy−1 cm−2 at 400 V mm−1 under 50 kVp. Notably, the device also excels in alpha particle detection, boasting a resolution of ~14.48 % under a bias of 400 V bias. The hole mobility‐lifetime product (μτ)h of Pb2P2Se6 is estimated to be ~2.58×10−5 cm2 V−1. The results underscore potential applications of Pb2P2Se6 crystal is in the field of the semiconductor radiation detectors.
Building Trust in AI Farming Tools
Authors: Joosse Tess 
Published: July 2024

AbstractPrecision agriculture tools like decision support systems increasingly use machine‐learning algorithms and other types of artificial intelligence (AI) to analyze large quantities of agricultural data and provide recommendations to producers and crop advisers. However, several barriers threaten adoption of these tools. Three papers in the recent Agronomy Journal special section, “Machine Learning in Agriculture,” explore this phenomenon and offer solutions and opportunities for building trust in these technologies. Earn 0.5 CEUs in Crop Management by reading this article and taking the quiz at https://web.sciencesocieties.org/Learning‐Center/Courses.
Managerial practices and firms' environmental performance: An international evidence
Authors: Doan Thang Ngoc , Vu Chi Thi Kim 
Published: July 2024

AbstractThis study investigates the impact of managerial practices on environmental performance using firm‐level data from Eastern European and Central Asian regions collected during the 2019–2020 period through the World Bank Enterprise Surveys. Utilizing principal component analysis, we evaluate managerial practices across four key dimensions: targets, monitoring, incentives, and operations. Concurrently, we assess environmental performance through indicators encompassing energy efficiency, energy intensity, and disclosure practices. Our empirical findings highlight a strong correlation between higher scores in managerial practices and improved environmental performance within firms. These positive effects are transferred through environmental targets and adoptions, with moderation observed based on firm size. Robustness is evident in our results across various measures of environmental performance and managerial practices, as well as when accounting for potential endogeneity issues. This research offers valuable insights with implications for both policy development and managerial decision‐making, fostering sustainability and responsible practices.
Secured and energy aware cluster‐based routing in cross‐layer–cross‐domain WSN
Authors: Lahane Shivaji R. , Lahane Priti S. 
Published: July 2024

SummaryWireless sensor networks (WSNs) are becoming increasingly important and well liked for delivering pervasive computing environments for a range of applications. Extending the networking life lifetime in WSNs is an important issue that must be addressed. Effective techniques for conserving the WSN's limited energy resources must be developed. Cross‐layer protocols are employed in WSNs to solve network lifespan difficulties. This paper proposes a new cross‐layer–cross‐domain routing scheme with stages such as “(1) network association stage, (2) nearer node detection phase, and (3) consistent state phase.” In the consistent stage, the optimal cluster head selection (CHS) is carried out by taking into account risk, delay, energy, trust, and distance. A new model called manta ray collided dwarf mongoose optimization (MRC‐DMO) is introduced to help with this. Furthermore, the routing is accomplished by dependable data communication. The results obtained establish the effectiveness of the MRC‐DMO scheme for SEACRCLCD in WSN over varied methods.
SDR implementation of wideband spectrum sensing using machine learning
Authors: Sabrina Zeghdoud , Camel Tanougast , Djamal Teguig , Ammar Mesloub , Said Sadoudi , Belqassim Bouteghrine 
Published: July 2024

SummaryNew cognitive radio (CR) systems require high throughput and bandwidth. Hence, CR users need to detect wide frequency bands of the radio spectrum to exploit unused frequency channels. This paper proposes a new wideband spectrum sensing (WBSS) detection approach based on machine learning (ML) for scanning subchannels. The originality of the proposed approach is to detect spectrum opportunities using a narrowband spectrum sensing (NBSS) method‐based support vector machine (SVM) classification and two features: energy and goodness of fit (GoF). The simulation results show that the proposed WBSS approach‐based ML presents a higher probability of detection than the WBSS approach‐based conventional detectors, even at low signal‐to‐noise ratio (SNR). Finally, the software defined radio (SDR) implementation validates the proposed WBSS approach for real detection scenarios.
Plasma p‐tau217 concordance with amyloid PET among ethnically diverse older adults
Authors: Asken Breton M. , DeSimone Jesse C. , Wang Wei‐En , McFarland Karen N. , Arias Franchesca , Levy Shellie‐Anne , Fiala Jacob , Velez‐Uribe Idaly , Mayrand Robin P. , Sawada Luana Okino , Freytes Christian , Adeyosoye Michael , Barker Warren W. , Crocco Elizabeth A. , DeKosky Steven T. , Adjouadi Malek , Rosselli Monica , Marsiske Michael , Armstrong Melissa J. , Smith Glenn E. , Cid Rosie Curiel , Loewenstein David A. , Vaillancourt David E. , Duara Ranjan 
Published: July 2024

AbstractINTRODUCTIONCommercially available plasma p‐tau217 biomarker tests are not well studied in ethnically diverse samples.METHODSWe evaluated associations between ALZPath plasma p‐tau217 and amyloid‐beta positron emission tomography (Aβ‐PET) in Hispanic/Latino (88% of Cuban or South American ancestry) and non‐Hispanic/Latino older adults. One‐ and two‐cutoff ranges were derived and evaluated to assess agreement with Aβ‐PET.RESULTSA total of 239 participants underwent blood draw and Aβ‐PET (age 70.8 ± 7.8, 55.2% female, education 15.6 ± 3.4 years, 48.9% Hispanic/Latino, 94.9% white). Plasma p‐tau217 showed excellent discrimination of Aβ‐PET positive and negative participants (visual read: AUC = 0.91 [0.87–0.95], p < 0.001; Centiloids quantification: AUC = 0.90 [0.86–0.94]). There was a greater percent agreement between low p‐tau217 and negative Aβ‐PET (95.8%) than high p‐tau217 and positive Aβ‐PET (86.3%). Analyses within ethnicity‐specific subgroups suggested similar p‐tau217 performance.DISCUSSIONPlasma p‐tau217 (ALZPath) relates to brain Aβ in Hispanic/Latino and non‐Hispanic/Latino older adults. Independent validation and replication are necessary to establish reference ranges and inform appropriate contexts of use across ethno‐racially diverse populations.HIGHLIGHTS
Plasma p‐tau217 (ALZPath) and Aβ‐PET were measured in Hispanic/Latino and non‐Hispanic/Latino older adults.
Plasma p‐tau217 accurately discriminated Aβ‐PET positive and negative participants.
Applying a two‐cutoff “intermediate” plasma p‐tau217 approach could reduce need for more invasive and costly testing.
Plasma p‐tau217 associations with Aβ‐PET were strong within both Hispanic/Latino and non‐Hispanic/Latino groups.
Effects of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction: An analysis of DAPA‐HF and DELIVER
Authors: Abdin Amr , Kondo Toru , Böhm Michael , Jhund Pardeep S. , Claggett Brian L. , Vaduganathan Muthiah , Hernandez Adrian F. , Lam Carolyn S.P. , Inzucchi Silvio E. , Martinez Felipe A. , de Boer Rudolf A. , Desai Akshay S. , Køber Lars , Sabatine Marc S. , Petersson Magnus , Bachus Erasmus , Solomon Scott D. , McMurray John J.V. ,   on behalf of the DAPA‐HF and DELIVER Committees and Investigators
Published: July 2024

AbstractAimsThe primary aim was to evaluate the effect of dapagliflozin according to QRS duration across the spectrum of left ventricular ejection fraction (LVEF), given that prolongation of QRS duration is associated with less favourable ventricular remodelling with pharmacological therapy and worse outcomes.Methods and resultsA pooled analysis of the DAPA‐HF and DELIVER trials, excluding patients with a paced rhythm and cardiac resynchronization therapy. Overall, 4008 patients had heart failure (HF) with reduced ejection fraction (HFrEF), and 5816 had HF with mildly reduced/preserved ejection fraction (HFmrEF/HFpEF). QRS duration was <120 ms in 7039 patients (71.7%), 120–149 ms in 1725 (17.6%), and ≥150 ms in 1060 patients (10.8%). The median follow‐up time was 23 months. The rate of the primary composite outcome of cardiovascular death or worsening HF was 9.2 (95% confidence interval [CI] 8.7–9.7), 14.3 (13.0–15.7), and 15.9 (14.1–17.9) per 100 patient‐years in the <120, 120–149, and ≥150 ms groups, respectively. This gradient in event rates was observed both in HFrEF and HFmrEF/HFpEF. Dapagliflozin, compared with placebo, reduced the risk of the primary outcome consistently across the QRS duration subgroups (hazard ratio [95% CI] 0.75 [0.67–0.85], 0.79 [0.65–0.96], and 0.89 [0.70–1.13] in the <120, 120–149, and ≥150 ms groups, respectively; p for interaction = 0.28). The effect of dapagliflozin on the primary outcome was consistent across the QRS duration regardless of HF phenotype that is, HFrEF or HFmrEF/HFpEF.ConclusionsProlongation of QRS duration is associated with worse outcomes irrespective of HF phenotype. Dapagliflozin reduced the risk of the primary outcome, regardless of QRS duration, in DAPA‐HF and DELIVER.
Short‐ and medium‐term effects of a single session of pain neuroscience education on pain and psychological factors in patients with chronic low back pain. A single‐blind randomized clinical trial
Authors: Tomás‐Rodríguez Mª. Isabel , Asensio‐García María Del Rosario , García Rauf Nouni , Delicado‐Miralles Miguel , Sánchez Sergio Hernández , Segura‐Heras Jose Vicente 
Published: July 2024

AbstractIntroductionBiopsychosocial approach in patients suffering chronic low back pain (CLBP) promotes pain self‐management strategies. Current evidence recommends high dose of Pain Neuroscience Education (PNE) for clinically significant differences. However, the workload and time constraints experienced by healthcare providers impede the application of the recommended treatment regimen. In fact, Back School with a biomechanical model is the main approach to manage CLBP in public systems.ObjectiveThe objective of this study is to explore the effect of a 60 min single session of PNE as an adjunct to back school on pain intensity and psychological variables patients with CLBP.MethodsA double‐blind, two‐arm randomized controlled clinical trial was conducted in patients with CLBP who attended back school sessions held in a Spanish public hospital. A total of 121 patients were randomized into control group, who received the Back School program during 5 weeks, and intervention group, who additionally received a single session of PNE. Patient‐reported outcomes were the Numerical Pain Rating Scale, Central Sensitization Inventory, Pain Catastrophizing Scale, and Tampa Scale of Kinesiophobia, with a 12‐week follow‐up.ResultsA total of 113 patients were analysed. Intervention and control group presented similar effects on pain and kinesiophobia. At follow‐up, intervention group exhibited reduced sensitization and catastrophism scores compared with control, including the subscales. Additionally, PNE reduced the percentage of participants classified as having central sensitization compared with control.ConclusionsAdding a single PNE session in the back school program did not reduce pain but improved psychological factors as central sensitization and pain catastrophizing at medium‐term. This study highlights the potential of PNE to optimize treatment strategies for CLBP, especially in public health centres where time resources are scarce.Significance StatementAdding a single PNE session in the back school program did not reduce pain but improved psychological factors as central sensitization and pain catastrophism at medium‐term.
Improving oxidative stability of cream powder using pomegranate concentrate and peel extract
Authors: Khademi Seyed Ayuob , Eskandari Mohammad Hadi , Golmakani Mohammad Taghi , Niakousari Mehrdad , Hashemi Hadi 
Published: July 2024

AbstractIn this study, the influence of pomegranate peel extract (PPE) and pomegranate concentrate (PC) on improving the oxidative stability of cream powder in comparison with synthetic antioxidant (Butylated hydroxytoluene (BHT)) during the storage period at 20°C (8 weeks) and 45°C (4 weeks) was evaluated. The finding exhibited that peroxide, p‐anisidine, and total oxidation (TOTOX) values increased during the storage period. Samples containing PPE and PC showed suitable performance in controlling the cream powder oxidation. Also, PPE showed the highest antioxidant activity and can be proposed as a suitable replacement for a synthetic antioxidant (BHT). L* and b* values increased, while a* value decreased during the storage period. Also, the pH of the powders decreased significantly throughout the storage (reached nearly 6). Microbial counts of cream powders did not change during the storage period. The control sample showed the highest overall acceptability. Antioxidants of pomegranate can be proposed to control the oxidative stability of fat‐rich food products.