bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hope(lessness) in the Stories of Abraham and Sisyphus
Authors: Vičanová Gabriela 
Published: July 2024

Abstract
When looked at under the perspective of hope, existential philosophers Albert Camus and Søren Kierkegaard are typically seen as inverted images of one another: Kierkegaard embraces hope, which for him is a religious sentiment that he describes at length in Fear and Trembling through the character of Abraham. Camus – on the other hand – rejects hope, seeing both Kierkegaard and Abraham as individuals who had committed what Camus terms a ‘philosophical suicide.’ Camus’ The Myth of Sisyphus can thus be understood as an answer to Kierkegaard’s Abraham: Sisyphus – unlike Abraham – is an individual who had accepted the absurd nature of the world, rejected hope, and thus achieved happiness. In my paper, I will argue that Camus’ criticism of Kierkegaard and of Abraham is not final – I will argue that Camus, in fact, sees hope as an existentially important phenomenon. I will show that Camus does not reject hope in The Myth of Sisyphus but that he merely temporarily suspends it, only to return to it in his later writings. The Myth of Sisyphus is therefore only one of the many ‘stages on life’s way,’ and I will argue that hope is an important aspect of human existence not only for Kierkegaard but also for Camus. That said, Camus’ understanding of hope will not be the same as Kierkegaard’s; hope will exist not in relation to God, but in a relationship with other human beings.
The impact of the COVID-19 pandemic on the performance of the Rapid Access Lung Cancer Clinic
Authors: Ghassemi-Rad Mohammad J. , Dennehy Colum , Lyons Noreen , Henry Michael T. , Kennedy Marcus P. , O’Reilly Éilis J. , Connolly Roisin M. 
Published: July 2024

Abstract
Background
The Rapid Access Lung Cancer Clinic (RALC) experienced fewer referrals during the COVID-19 pandemic in Ireland.

Aims
Our aim was to determine the impact of the pandemic on the key performance indicators (KPIs) of the Cork University Hospital (CUH) RALC, using a retrospective chart review of the referrals and attendances.

Methods
The medical charts of patients referred to CUH-RALC from 03/2019 to 02/2020 (period I), and from 03/2020 to 02/2021 (period II) were reviewed. Performance of the RALC was determined based on average wait time from referral to 1] acquisition of the first CT scan, 2] consultation, and 3] receiving a cancer diagnosis, and compared between periods I and II.

Results
Average monthly referrals (57.3 vs 42.1, p = 0.0078) and RALC reviews (24.3 vs 22, p = 0.0310) were lower in period II compared to period I. However, no difference was seen in the length of time from referral to review at RALC or time to receive cancer diagnosis. There were shorter wait times from referral to CT scan (11.2 vs. 8.7 days, p = 0.0011) and to surgery (109.0 vs 79.3 days, p = 0.0236) in period II.

Conclusions
The COVID-19 pandemic had minimal impact on the performance of RALC at our institution. Fewer referrals to RALC in period II may relate to hesitancy in attending general practitioner (GP) and/or GPs raising the thresholds for referrals to RALC during the early lockdown period of the pandemic. A national evaluation will be required to fully determine the impact of this pandemic on lung cancer in Ireland.
Blood Cancer Network Ireland (BCNI) and National Cancer Registry Ireland (NCRI) collaboration: challenges and utility of an Enhanced Blood Cancer Outcomes Registry (EBCOR) pilot
Authors: Millar Seán R. , Mohamed Mohamed Bakri , Mykytiv Vitaliy , McMorrow Rose , Donnelly Conan , O’Leary Eamonn , Orfali Nina , Murphy Philip , Browne Paul V. , Quinn John , O’Gorman Peter , Ryan Mary F. , Clifford Ruth , Hassadi Ezzat El , O’Shea Derville , Gilligan Oonagh , Krawczyk Janusz , O’Dwyer Michael E. , Szegezdi Eva , Cahill Mary R. 
Published: July 2024

Abstract
Background
The Blood Cancer Network Ireland and National Cancer Registry Ireland worked to create an Enhanced Blood Cancer Outcomes Registry (EBCOR). Enhanced data in acute myeloid leukaemia (AML) included an extensive data dictionary, bespoke software and longitudinal follow-up.

Aims
To demonstrate the utility of the database, we applied the data to examine a clinically relevant question: Charlson comorbidity index (CCI) usefulness in predicting AML patients’ survival.

Methods
A software designer and consultant haematologists in Cork University Hospital worked together to standardise a data dictionary, train registrars and populate a database. One hundred and forty-one AML patients underwent enhanced data registration. Comorbidities identified by chart review were used to examine the capability of the CCI and age at diagnosis to predict mortality using Kaplan–Meier curves, Cox regression and receiver operating characteristic curves.

Results
In regression analysis, a dose–response relationship was observed; patients in the highest CCI tertile displayed a greater risk (HR = 4.90; 95% CI 2.79–8.63) of mortality compared to subjects in tertile 2 (HR = 2.74; 95% CI 1.64–4.57) and tertile 1 (reference). This relationship was attenuated in an analysis which adjusted for age at diagnosis. The area under the curve (AUC) for the CCI was 0.76 (95% CI 0.68–0.84) while the AUC for age at diagnosis was 0.84 (95% CI 0.78–0.90).

Conclusions
Results suggest that the CCI provides no additional prognostic information beyond that obtained from age alone at AML diagnosis and that an EBCOR can provide a rich database for cancer outcomes research, including predictive models and resource allocation.
Approach to the patient with eosinophilia in the era of tyrosine kinase inhibitors and biologicals
Authors: Lübke Johannes , Metzgeroth Georgia , Reiter Andreas , Schwaab Juliana 
Published: July 2024

Abstract
Purpose of Review
In this review, we aim to explore the optimal approach to patients presenting with eosinophilia, considering recent advances in diagnostic and therapeutic strategies. Specifically, we focus on the integration of novel therapies into clinical practice to improve patient outcomes.

Recent Findings
Advanced insights into the clinical and genetic features of eosinophilic disorders have prompted revisions in diagnostic criteria by the World Health Organization classification (WHO-HAEM5) and the International Consensus Classification (ICC). These changes reflect a growing understanding of disease pathogenesis and the development of targeted treatment options. The therapeutic landscape now encompasses a range of established and novel therapies. For reactive conditions, drugs targeting the eosinophilopoiesis, such as those aimed at interleukin-5 or its receptor, have demonstrated significant potential in decreasing blood eosinophil levels and minimizing disease flare-ups and relapse. These therapies have the potential to mitigate the side effects commonly associated with prolonged use of oral corticosteroids or immunosuppressants. Myeloid and lymphoid neoplasms with eosinophilia and tyrosine kinase (TK) gene fusions are managed by various TK inhibitors with variable efficacy.

Summary
Diagnosis and treatment rely on a multidisciplinary approach. By incorporating novel treatment options into clinical practice, physicians across different disciplines involved in the management of eosinophilic disorders can offer more personalized and effective care to patients. However, challenges remain in accurately diagnosing and risk-stratifying patients, as well as in navigating the complexities of treatment selection.
Diagnostic dilemma in Cushing’s syndrome: discrepancy between patient-reported and physician-assessed manifestations
Authors: Motomura Yuma , Urai Shin , Bando Hironori , Yamamoto Masaaki , Suzuki Masaki , Yamamoto Naoki , Iguchi Genzo , Ogawa Wataru , Fukuoka Hidenori 
Published: July 2024

Abstract
Purpose
Early diagnosis and immediate treatment of Cushing’s syndrome (CS) are critical for a better prognosis but remain a challenge. However, few comprehensive reports have focused on this issue or investigated whether patient-reported manifestations are consistent with physician-assessed symptoms of CS. This study aimed to clarify the differences in patient-reported and physician-assessed manifestations of signs and symptoms of CS that prevent early diagnosis.

Methods
This single-center retrospective study included 52 patients with CS (16 with Cushing’s disease and 36 with adrenal CS). Upon clinical diagnosis, medical records were used to independently review the patient-reported and physician-assessed manifestations of typical (such as purple striae and proximal myopathy) and nonspecific features (such as hirsutism and hypertension). The correlations and differences between the patient-reported and physician-assessed manifestations were then analyzed.

Results
We observed a positive correlation between the total number of manifestations of nonspecific features reported by patients and those assessed by physicians, but not for typical features. Moreover, manifestations reported by the patients were less frequent than those assessed by physicians for typical features, leading to discrepancies between the two groups. In contrast, there were no differences in most nonspecific features between the patient-reported and physician-assessed manifestations. Notably, the concordance between patient-reported and physician-assessed manifestations of typical features was not associated with urinary free cortisol levels.

Conclusion
Regardless of disease severity, patients often do not complain of the typical features of CS that are crucial for formulating a diagnosis.
Prenatal affective bond: a longitudinal study in women who achieved pregnancy through assisted reproduction
Authors: Navarro-Aresti Lucía , Gordo Leire , Iriarte Leire , Iraurgi Ioseba , Estévez Ana , Martínez-Pampliega Ana 
Published: July 2024

AbstractThe prenatal maternal affective bond can be understood as the emotional relationship that a pregnant woman establishes with her unborn child. This prenatal relationship develops gradually during the entire pregnancy. To study the prenatal maternal affective bond, and the variables involved therein, over the entire gestation for women who achieved pregnancy through assisted reproduction techniques (ART). We conducted a longitudinal study in which we evaluated 49 women at the three gestational trimesters: after the ultrasound confirmation of heart beat (from the 6th – 7th week of pregnancy), around the 20th week of gestation, and as of week 34. This study reflects, among other issues, that the prenatal maternal affective bond is very high from the beginning of pregnancy and increases trimester-by-trimester, showing very high levels at the end of the pregnancy. While the small number of participants has limited the statistical power, the data obtained are a first approximation to the studied reality that allows us to identify variables on which to continue working in future studies.
Informal Learning in Business Internships in Higher Education – Findings from a Diary Study
Authors: Brodsky Alexander , Rausch Andreas , Seifried Jürgen 
Published: July 2024

AbstractInternships offer the opportunity to gain experience and skills by working in organisations or to establish a professional network, and there is empirical evidence of the positive effects of practical experience in higher education. However, there are only a few studies on the characteristics of workplace tasks that facilitate learning during internships. In this paper, we address this research gap by conducting a diary study to examine students' work tasks at the beginning and end of an eight-week business internship period, their perceptions of the tasks, and the influence of task characteristics on self-perceived learning. Analyses of approximately 2,000 work tasks documented by 51 students show that the frequencies of different work tasks did not differ substantially between the first and last week of the business internship. At both times of data collection, many students were engaged in organisational routine and administrative tasks, especially those with a domain-specific focus. However, the values for the assessment of task characteristics (such as challenge/difficulty) were higher at the beginning of the internship than towards the end. Causal analyses revealed that task characteristics such as novelty or feedback (from colleagues or supervisors) were positive predictors of self-perceived learning during both weeks, whereas the predictive power of other task features changed. For example, help received (from colleagues or supervisors) was a significant predictor in the first week of the internship but not in the last; the opposite was the case for autonomy. From these results, we derive implications for both future research and the active design of internships in the higher education context.
Contextually Sensitive Polyvictimization Profiles and Physical and Mental Health Outcomes among South African Adolescents from Low-Resource Communities: An Extended Latent Class Analysis
Authors: Franchino-Olsen Hannabeth , Spreckelsen Thees , Orkin Mark , Meinck Franziska 
Published: July 2024

AbstractAdolescents in South Africa may experience violence victimizations in many forms (abuse, bullying, assault) and across many contexts (home, school, community). Polyvictimization is a valuable framework to examine the diversity of violence in adolescents’ lives, particularly when employed alongside person-centered methods such as latent class analysis. This study builds on previous work examining contextually sensitive patterns of polyvictimization among South African adolescents and uses longitudinal Young Carers data (n = 3401) from highly-deprived, low-resource settings to investigate the associations between latent class polyvictimization profiles and physical and mental health outcomes using the Bolck–Croon–Hagenaars (BCH) method. Key results found that adolescents who experienced high polyvictimization alongside contextual factors (poverty, disability, etc.) had greater odds of suicidality and higher scores for depression and anxiety measures than their peers who experienced moderate or low polyvictimization. These outcomes were often worse within the high polyvictimization classes for those participants experiencing burdens of HIV/AIDS and disability. Results were mixed for the physical health outcomes (chronic health condition; recent poor health) and when distinguishing between the moderate and low polyvictimization classes, as some classes characterized by decreased polyvictimization had worse health outcomes. These findings highlight the need to consider polyvictimization as a relevant health risk and contextual factor when addressing the health and well-being needs of South African adolescents. Health programming and policy efforts should seek to screen for and address the causes of and distress from polyvictimization when targeting adolescents and provide a cohesive response to the adolescent violence and health burdens in low-resource communities.
Nano Photo Bleaching Method of Cotton Fabrics for a Sustainable Finishing
Authors: Basyigit Zeynep Omerogullari , Ciğeroğlu Zeynep 
Published: July 2024

AbstractIn modern textile-bleaching methods, H2O2 is commonly preferred due to its less harmful effects on the environment. The use of hydrogen peroxide in bleaching processes, although biodegradable on its own, increases the waste load due to the high amount of auxiliary chemicals used. The long processing times and high-temperature requirements of hydrogen peroxide bleaching led to increased energy consumption. Moreover, the high-water consumption required for post-treatment is also a disadvantageous factor. In other words, while the use of a high amount of auxiliary chemicals in hydrogen peroxide bleaching increases the waste load, long time and high-temperature requirements also increase energy consumption, and the high-water consumption required for post-treatment has a disadvantageous effect. In this study, raw cotton fabric is subjected to chemical finishing treatments that either oxidize or reduce it as part of the bleaching process. The results of photo bleaching were compared with conventional hydrogen peroxide finishing applications. Our findings showed that nano-TiO2-treated cotton had a better whiteness value than treated with H2O2 cotton according to the color spectrum whiteness indexes. It is strongly considered that this method could be a new alternative way for bleaching textile materials in the finishing departments.
The Effect of Sediment Mud Content on Primary Production in Seagrass and Unvegetated Intertidal Flats
Authors: Flowers Georgina J. L. , Needham Hazel R. , Bulmer Richard H. , Lohrer Andrew M. , Pilditch Conrad A. 
Published: July 2024

AbstractAs a consequence of anthropogenic activities and climate change, accelerated terrestrial sediment runoff is causing the gradual mudification of soft sediment estuarine habitats worldwide. Increased sediment mud content (< 63 µm) has been recognised to alter seagrass morphology and cause declines in primary production in unvegetated habitats. However, the effect of increased mud content on primary production in seagrass meadows remains largely unknown. To address this, primary production in intertidal seagrass meadows (Zostera muelleri) and adjacent unvegetated habitats was measured in situ using benthic incubation chambers across an existing sedimentary gradient (nine sites spanning 5–33% mud content). An additional two unvegetated mudflat sites (39–49% mud content) were also sampled to expand the gradient. Seagrass net (NPP) and gross primary production (GPP) was greater than in the adjacent unvegetated habitat and did not vary with mud content, even after standardising GPP by photosynthesising biomass (i.e. photosynthetic efficiency). In contrast, in the adjacent unvegetated habitat, photosynthetic efficiency declined with increasing mud content. Inclusion of the additional mudflat sites negatively impacted NPP, GPP, and photosynthetic efficiency in the unvegetated habitat. Thus, while primary production in seagrass meadows may have some resilience to future increases in mud content (up to ~33%), further degradation and loss of seagrass habitats could result in the expansion of unvegetated habitats and ultimately lead to production losses, likely to be most acute in areas with high mud content (≥ 39%).
Fluconazole-Niosome-Laden Contact Lens: A Promising Therapeutic Approach for Prolonged Ocular Delivery and Enhanced Antifungal Activity
Authors: Yassin Ghada E. , Amer Mai A. , Mannaa Islam M. , Khalifa Maha Khalifa Ahmed 
Published: July 2024

Abstract
Background
Traditional routes of administration of fluconazole such as eye drops have a low therapeutic efficacy due to insufficient bioavailability.

Purpose
Herein, a fluconazole noisome-laden contact lens was prepared to control and prolong the drug release and improve its bioavailability.

Methods
Two methods have been used to prepare fluconazole niosomes: solvent injection method and thin film hydration method utilizing span 60 and cholesterol mixture. Subsequently, formulations were optimized using three factors and a two-level factorial design and were subjected to in-vitro characterization for the size of niosomes, zeta potential, entrapment efficiency percent, and cytotoxicity study. The optimized fluconazole niosomes were further entrapped in contact lenses by the soaking method and were evaluated according to in-vitro release profile, and antimicrobial activity.

Results
The results revealed that the investigated fluconazole niosomes are of nano-size ranging from 228.2 to 769.2 nm with zeta-potential values between − 18.1 and − 60.2 mV. The entrapment efficiency percentage ranged from 51.3 to 75%. Fluconazole was released from fluconazole noisome-laden contact lens and showed a prolonged release up to 48–72 h with a cumulative release of 79.62%. Statistical analysis showed that fluconazole-noisome-laden contact lenses have a significant impressive fungal adhesion reduction as compared to fluconazole-laden contact lenses.

Conclusion
Fluconazole noisome-laden contact lenses are a promising therapeutic way for effective and prolonged treatment of ocular fungal infection.
De toepassing van de Groentehapjes-in-10-stapjes-tool voor ouders van zuigelingen
Authors: ter Bogt Maud J. J. , Rutten Nickee , Gerards Sanne M. P. L. , Bessems Kathelijne M. H. H. 
Published: July 2024

SamenvattingVoldoende groenteconsumptie helpt bij het terugdringen van chronische ziekten. Helaas wordt er nog steeds beperkt groenten gegeten. Het introduceren van groenten bij zuigelingen van vier maanden stimuleert de ontwikkeling van smaakvoorkeuren. Groentehapjes-in-10-stapjes (G10) is een voorlichtingstool gericht op groente-introductie voor ouders die toegepast wordt door de Jeugdgezondheidszorg (JGZ). We hebben onderzocht hoe de tool wordt toegepast door de JGZ-professionals en ouders. In 2021 zijn tien JGZ-professionals en tien ouders geïnterviewd. JGZ-professionals gaven aan dat ze de tool aan vrijwel alle ouders gaven en dat de tool ondersteunde bij voorlichting over groente-introductie. De meeste ouders vertelden dat ze groenten introduceerden volgens de hoofdboodschappen met de materialen. JGZ-professionals gaven aan dat ze de introductie aanpasten op basis van hun eigen ervaring met groente-introductie, kenmerken van ouders (zoals cultuur) en de consultsetting (zoals tijd). Ouders vertelden dat ze de toepassing van de adviezen aanpasten aan kenmerken van hun kind, de gezinssituatie en hun interpretatie. Groentehapjes-in-10-stapjes leek een waardevol instrument voor JGZ-professionals en ouders bij het introduceren van groenten bij zuigelingen. We doen enkele aanbevelingen voor JGZ-professionals (onder andere pas Groentehapjes-in-10-stapjes toe), de tool-ontwikkelaar (bijvoorbeeld suggesties voor optimalisatie van Groentehapjes-in-10-stapjes) en onderzoek (onder meer een effectonderzoek).
The chemokine CCL14 is a potential biomarker associated with immune cell infiltration in lung adenocarcinoma
Authors: Sun Bai-er , Yuan Zai-xin , Wang Meng-jiao , Xu Li-qin , Feng Jian , Chen Jing-jing 
Published: July 2024

Abstract
Background
Chemokine ligand 14, which has a C–C motif (CCL14), mediates the immunological milieu around tumors. However, its role in the progression of lung adenocarcinoma (LUAD) is still unknown. Our objectives were to study the association between CCL14 and tumor-infiltrating immune cells (TIICs) as well as the predictive significance of CCL14 in LUAD.

Methods
The expression of CCL14 in LUAD was examined by using the Oncomine, The Cancer Genome Atlas (TCGA), The University of Alabama at Birmingham CANcer data analysis Portal (UALCAN), and Human Protein Atlas databases. To determine the prognostic significance of CCL14 in LUAD, researchers used the Kaplan‒Meier plotter and Gene Expression Profiling Interactive Analysis (GEPIA, version 2). We utilized TIMER and GEPIA2 to investigate the connection between CCL14 and TIICs. Gene set enrichment analysis (GSEA) was used to test for functional enrichment of genes. We used RT‒qPCR to measure CCL14 expression and Cell Counting Kit-8, Transwell, and wound healing assays to investigate the biological role of CCL14.

Results
The prognosis of patients with LUAD was worse when CCL14 expression was low. Statistical analysis revealed that CCL14 mRNA expression was significantly greater in lung epithelial cells than in LUAD cell lines in vitro. Enhancing CCL14 expression reduced cell migration, invasion, and proliferation. The results of the immune infiltration research showed that CCL14 and TIICs were positively correlated. Different immune infiltration patterns associated with CCL14 were also shown by TIIC markers. According to GSEA, histone deacetylases, G2/M checkpoints, and Notch signaling pathways were associated with low CCL14 expression.

Conclusions
CCL14 is anticipated to emerge as a prognostic marker and therapeutic target for LUAD due to its role in regulating TIICs, suggesting that it may be an antioncogene.