bluuebunny/crossref_metadata_2025_split huggingface dataset:
Receptivity and preferences of pancreatic cancer family members for participating in lifestyle programs to reduce cancer risk
Authors: Howell Lisa A , Sinicrope Pamela S , Brockman Tabetha A , Patten Christi A , Decker Paul A , Ehlers Shawna L , Nadeau Ashley , Rabe Kari G , Breitkopf Carmen Radecki , Petersen Gloria M 
Published: June 2013

Abstract

Background
Cancer is a shared family experience that might provide an opportunity for lifestyle change among at-risk family members. The purpose of this study was to assess receptivity and preferences for cancer risk reduction programs among at-risk family members with two or more relatives affected with pancreas cancer.

Methods
We surveyed 401 at-risk family members in an existing pancreatic cancer family registry. Participants completed a mailed survey which examined demographic, medical, and psychosocial correlates of willingness to participate in lifestyle cancer risk reduction programs. Multivariable generalized estimating equation approaches were used to model preferences.

Results
Overall, 85% (n = 342) of at-risk family members were receptive to lifestyle cancer risk reduction programs. Participant preferred programs focused on nutrition (36%, n = 116) and weight management (33%, n = 108), with Web/Internet (46%, n = 157) being the most preferred delivery channel. Most respondents preferred to participate in programs with their family or friends (74%, n = 182), rather than alone (25%, n = 85). In multivariable analysis, younger age (p = 0.008) and higher perceived likelihood of developing cancer (p = 0.03) were associated with willingness to participate in lifestyle programs.

Conclusions
Family members of those with pancreatic cancer are receptive to cancer risk reduction programs focusing on nutrition and weight management delivered via the internet. Further research is indicated to determine how to best incorporate a family-based approach when designing lifestyle intervention programs.
Novel birch pollen specific immunotherapy formulation based on contiguous overlapping peptides
Authors: Pellaton Céline , Perrin Yannick , Boudousquié Caroline , Barbier Nathalie , Wassenberg Jacqueline , Corradin Giampietro , Thierry Anne‐Christine , Audran Régine , Reymond Christophe , Spertini François 
Published: June 2013

AbstractBackgroundSynthetic contiguous overlapping peptides (COPs) may represent an alternative to allergen extracts or recombinant allergens for allergen specific immunotherapy. In combination, COPs encompass the entire allergen sequence, providing all potential T cell epitopes, while preventing IgE conformational epitopes of the native allergen.MethodsIndividual COPs were derived from the sequence of Bet v 1, the major allergen of birch pollen, and its known crystal structure, and designed to avoid IgE binding. Three sets of COPs were tested in vitro in competition ELISA and basophil degranulation assays. Their in vivo reactivity was determined by intraperitoneal challenge in rBet v 1 sensitized mice as well as by skin prick tests in volunteers with allergic rhinoconjunctivitis to birch pollen.ResultsThe combination, named AllerT, of three COPs selected for undetectable IgE binding in competition assays and for the absence of basophil activation in vitro was unable to induce anaphylaxis in sensitized mice in contrast to rBet v 1. In addition no positive reactivity to AllerT was observed in skin prick tests in human volunteers allergic to birch pollen. In contrast, a second set of COPs, AllerT4‐T5 displayed some residual IgE binding in competition ELISA and a weak subliminal reactivity to skin prick testing.ConclusionsThe hypoallergenicity of contiguous overlapping peptides was confirmed by low, if any, IgE binding activity in vitro, by the absence of basophil activation and the absence of in vivo induction of allergic reactions in mouse and human.Trial registrationClinicalTrials.gov NCT01719133
Predictive impact of polymorphism of PNPLA3 on HCC development after interferon therapy in Japanese patients with chronic hepatitis C
Authors: Moritou Yuki , Ikeda Fusao , Iwasaki Yoshiaki , Baba Nobuyuki , Takaguchi Kouichi , Senoh Tomonori , Nagano Takuya , Takeuchi Yasuto , Yasunaka Tetsuya , Ohnishi Hideki , Miyake Yasuhiro , Takaki Akinobu , Nouso Kazuhiro , Yamamoto Kazuhide 
Published: June 2013

Abstract
The impact of single-nucleotide polymorphisms (SNP) of patatin-like phospholipase domain-containing protein 3 (PNPLA3) on development of hepatocellular carcinoma (HCC) is not clarified for Japanese patients with chronic hepatitis C. The present study investigated the associations of rs738409 PNPLA3 with HCC development after the antiviral therapy with peg-interferon and ribavirin for Japanese patients with hepatitis C virus serotype 1 and high viral load. Of the 271 patients enrolled in the study, 20 patients developed HCC, during a median follow-up period of 4.6 years. Multivariate analysis in the proportional hazards models revealed that sex, body mass index, platelet counts, and alpha feroprotein (AFP) had significant associations with HCC development (p = 0.011, 0.029, 0.0002, and 0.046, respectively). Multivariate regression analysis revealed that PNPLA3 148 M was significantly associated with serum AFP level (p = 0.032), other than body mass index, platelet count, and alanine aminotransferase (p = 0.0006, 0.0002, and 0.037, respectively), and that serum AFP level was significantly associated with PNPLA3 148 M (p = 0.017). Serum AFP level is an important factor in predicting HCC development after the antiviral therapy for Japanese patients with chronic hepatitis C, the mechanism of which might involve its significant associations with the SNP genotype of PNPLA3.
Medical risk factors of diabetes mellitus among professional drivers
Authors: Izadi Nazanin , Malek Maryam , Aminian Omid , Saraei Maryam 
Published: June 2013

Abstract
Background
Road transport drivers are one of the professional groups whose activities have a strong impact of public safety. In view of the natural professional activity, the drivers are at a higher risk of obesity, hypertension and hyperlipidemia, and carbohydrate metabolism disorders such as diabetes mellitus.

Materials and methods
Medical documentation was the source of data for the reported study. It derived from medical examinations of 1903 drivers applying for driving license.

Results
Hyperglycemia was found in 52.1% of the drivers, 9.1% of them were in diabetic stage, and with HbA1C criteria 77.6% of these drivers were in this stage. Excessive body weight was recorded in 65.6% of the study population, 44.8% were diagnosed with overweight and 20.8% with obesity. High blood pressure was recorded in 16.4% of drivers.

Conclusion
High prevalence of excessive body weight and high blood pressure and hyperlipidemia are risk factors for diabetes mellitus in professional drivers that indicates a need to undertake multidimensional actions target on this particular profession and involving various health care sectors. Prophylactic and detailed pre-placement examinations should be considered, depending on the rate and the intensity of disorders. These should be coupled with an introduction of primary and secondary prophylactic activities and monitoring of relevant treatment.
Macrocyclic Compound as NMR Chiral Solvating Agent for Determination of Enantiomeric Excess of Carboxylic Acids
Authors: Yang Xiao-feng , Ning Rui , Xie Li-jun , Cui Yu , Zhang Yong-ling , Zheng Lu-yi 
Published: June 2013

Abstract
1H NMR studies demonstrated that chiral macrocycle 1 was a good chiral solvating agent, and was effective for the determination of the enantiomeric excess of a wide range of rac-carboxylic acids. Large nonequivalent chemical shifts (up to 0.125 ppm) can be achieved in the presence of 1.0 equiv of 1.
Synthesis and Biological Evaluation of Aspergillide A/Neopeltolide Chimeras
Authors: Fuwa Haruhiko , Noto Kenkichi , Kawakami Masato , Sasaki Makoto 
Published: June 2013

Abstract
In this study, stereoisomeric aspergillide A/neopeltolide chimeras were synthesized in a parallel manner, and their antiproliferative activity was evaluated to demonstrate the potential utility of the 14-membered macrolactone structure embedded with a tetrahydropyran substructure as a template for developing natural product-like antiproliferative agents.
Preparation of Thin Poly(vinyl chloride) Films with Size-controlled Nanopores
Authors: Tanabe Ichiro , Yasuda Hajime , Tatsuma Tetsu 
Published: June 2013

Abstract
Thin poly(vinyl chloride) films with size-controlled nanopores (40–150 nm diameter) are prepared by a new and simple method on ITO-coated glass plates and TiO2 substrates by using monodisperse Au nanoparticles. These films are expected to be applied to nanomasks for nanoelectrode ensembles and templates for deposition of size-controlled metal nanoparticles.
Herbert Aldersmith (1847–1918): Christ's Hospital medical officer and co-founder of the Medical Officers of Schools Association
Authors: Hoskins Trevor 
Published: June 2013

Summary Herbert Aldersmith spent his entire working life, from the age of 23 years until his retirement at 65 years, as Resident Medical Officer to Christ's Hospital School. It was a crucial period in the school's history, from the overdue reforms of the late Victorian era to its historic move from the City of London to Sussex in 1902. He became an acknowledged authority on ringworm and also published extensively on the other great interest of his life, the British–Israel Society. He was the prime mover in founding the first-ever professional association of school doctors in 1884.
Daniel John Cunningham (1850–1909): anatomist and textbook author, whose sons achieved distinction in the Army, Navy and Indian Medical Service
Authors: Kaufman Matthew H 
Published: June 2013

Summary Daniel John Cunningham was a son of the manse. His father John (1819–93) was the parish priest at Crieff, Perthshire from 1845 and was to remain there for 41 years. In 1886 he was appointed Principal of St Mary's College of the University of St Andrews and Moderator of the Church of Scotland. Daniel was educated at Crieff Academy before he progressed to the University of Edinburgh. He graduated MB CM with First-class Honours in 1874 and then proceeded MD in 1876 when he was awarded a Gold Medal for his thesis. He acted as Demonstrator to Professor Turner (1832–1916) in Edinburgh for eight years until 1882 and was then appointed to the Chair of Anatomy at the Royal College of Surgeons of Ireland, in Dublin. After only one year there, he transferred to Trinity College, Dublin, where he occupied a similar position for 20 years. In 1903, on the appointment of Sir William Turner to the post of Principal and Vice-Chancellor of the University of Edinburgh, Daniel was invited to succeed him as Professor of Anatomy in Edinburgh. Daniel held this post until his premature death in 1909. He had three sons and two daughters. Each of his three sons achieved distinction in different fields – one in the Army, another in the Navy and the third in the Indian Medical Service. One of Daniel's daughters married Dr Edwin Bramwell (1873–1952), who was later to occupy the Moncrieff Arnott Chair of Clinical Medicine in the University of Edinburgh.
Sir Walter Langdon-Brown (1870–1946)
Authors: Keynes Milo 
Published: June 2013

Summary Sir Walter Langdon-Brown, born of robust Puritan stock, was a distinguished physician, teacher, medical historian and humanist at St Bartholomew's Hospital, London, before becoming Regius Professor of Physic at Cambridge. His contributions to clinical medicine were wide in relating symptoms and signs of disease to physiology, putting therapeutics on a scientific basis, showing the close linkage of the sympathetic nervous system to the ductless glands, and being regarded as a founder of clinical endocrinology. He was the first English physician to relate the work of Freud, Jung and Adler to clinical medicine and a pioneer in psychosomatic medicine and the study of neurotic behaviour.
William Arbuthnot Lane (1856–1943) and Kenelm Hutchinson Digby (1884–1954): a tale of two universities
Authors: Fu Kuo-Tai Louis 
Published: June 2013

Summary Sir William Arbuthnot Lane was one of the most brilliant British technical surgeons during the first half of the 20th century. Although some of his ideas may be controversial, he made many original contributions and innovations in surgical techniques. His greatest contribution was the introduction of the ‘no-touch technique’ in the open reduction and plating of long bone fractures by Lane's steel plates and screws. One of his registrars, Kenelm Hutchinson Digby, came to the Far East in 1913 as one of the first professors in the newly founded University of Hong Kong. Digby brought his former mentor's ideas to Hong Kong and inaugurated the practice of modern surgery there.
The many ailments of Herman Melville (1819–91)
Authors: Ross John J 
Published: June 2013

Summary Herman Melville developed debilitating physical and psychiatric disorders in middle age after writing, perhaps, the greatest of American novels, Moby Dick. This article critically examines claims that Melville had bipolar affective disorder and alcoholism, and suggests he may also have suffered from post-traumatic stress disorder. Melville was active and vigorous in youth but in middle age he developed recurrent attacks of eye pain, photophobia and disabling low back pain. Melville's contemporaries usually attributed his physical problems to ‘neurasthenia’ and his biographers have often dismissed them as psychosomatic. However, Melville's clinical course, abnormally rigid posture, loss of 1⅜ inches in height between the ages of 30 and 37, and a family history of rheumatological disease, suggest a diagnosis of ankylosing spondylitis.
Dr Edward Macgowan (1795–1860), a long-term pioneer physician in mid-nineteenth century Jerusalem: founder and director of the first modern hospital in the Holy Land
Authors: Lev Efraim , Perry Yaron 
Published: June 2013

Summary At the age of 46, Dr Edward Macgowan, by now a well-established physician, joined the ranks of the London Society for Promoting Christianity among the Jews with the aim of establishing the first modern hospital in Palestine. For the first six months of 1842, Macgowan established his work among the Jerusalem population on a regular basis and managed to establish a close relationship with the Jewish community and some of its leaders in Jerusalem. On 12 December 1844, the Jews' Hospital was opened in Jerusalem and became a source of great pride for the missionaries. Edward Macgowan died in Jerusalem after 18 years of service and was buried in the Protestant cemetery in his beloved city.
MicroRNAs in the Atherosclerotic Plaque
Authors: Raitoharju Emma , Oksala Niku , Lehtimäki Terho 
Published: June 2013

BACKGROUND
MicroRNAs (miRNA, miR) are noncoding RNAs that regulate gene expression by hindering translation. miRNA expression profiles have been shown to differ in vivo and in vitro in many cellular processes associated with cardiovascular diseases (CVDs). The progression of CVDs has also been shown to alter the blood miRNA profile in humans.

CONTENT
We summarize the results of animal and cell experiments concerning the miRNA profile in the atherosclerotic process and the changes which occur in the blood miRNA profile of individuals with CVD. We also survey the relationship of these CVD-related miRNAs and their expression in the human advanced atherosclerotic plaque, thereby providing more insight into miRNA function in human atherosclerotic lesions. The miRNAs miR-126, -134, -145, -146a, -198, -210, -340*, and -92a were found to be expressed differently in the blood of individuals affected and unaffected by CVD. These differences paralleled those seen in tissue comparisons of miRNA expression in advanced atherosclerotic plaques and healthy arteries. Furthermore, several miRNAs associated with atherosclerosis in in vitro studies (such as miR-10a, -126, -145, -146a/b, -185, -210, and -326) were expressed in plaques in a similar pattern as was predicted by the in vitro experiments. The clinical implications of miRNAs in atherosclerosis as biomarkers and as possible drug targets are also reviewed.

SUMMARY
miRNA profiles in in vitro and in vivo studies as well as in human peripheral blood are quite representative of the miRNA expression in human atherosclerotic plaques. miRNAs appear promising in terms of future clinical applications.
REVIEWS
Authors: Pressing Zsuzsanna , Gifford Dr Chris 
Published: June 2013

TRUE COMPETITION: A GUIDE TO PURSUING EXCELLENCE IN SPORT AND SOCIETY, DAVID LIGHT SHIELDS AND BRENDA LIGHT BREDEMEIER (2009) Champaign: Human Kinetics, 239 pp., ISBN: 978-0-7360-7429-2, p/bk, £ 18.95
INTERNATIONAL SOCIOLOGICAL ASSOCIATION HANDBOOK IN CONTEMPORARY SOCIOLOGY:
CONFLICT, COMPETITION AND COOPERATION, ANN DENIS AND DEVORAH KALEKIN-FISHMAN (EDS) (2009) London: Sage Publications Ltd, ISBN 978-1-4129-3463-3, 504 pages, £103 Hardcover, ebook £123.60.
Influence of dependent variables on granule formulation using factorial design: microwave irradiation as one of the factor
Authors: Avula Prameela Rani , Veesam Hema 
Published: June 2013

As traditional drug delivery poses many disadvantages such as difficulty in consumption, the granules were opted to replace tablet dosage forms available in the market. A 23 full factorial design was employed for the formulation and characterization of the granule dosage form of oxcarbazepine. From regression equations we can assess the impact of each factor on the response further contour plots helped to pre-analyze the desired target factor values, in addition optimization process helped to analyze the values of dependent variables. Thus as of the results achieved a preferred response of flow property and drug release was obtained. In the current study, an attempt has been made to minimize possible number of experiments in the formulation of granule dosage forms. Polyvidone is a hydrophilic binder and primellose is a good disintegrate to obtain higher dissolution rate. A part, microwave assisted drying process plays a major role in achieving desired flow properties of granules.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15153 International Current Pharmaceutical Journal, June 2013, 2(7): 115-118
Anti-inflammatory and antipyretic activity of Fioria vitifolia
Authors: Mahalakshmi Krishnamoorthi , Natesan Senthil Kumar , Parthiban Kugalur Ganesan , Sekar Ganesan 
Published: June 2013

Fioria vitifolia Linn., (Malvacae) has been extensively used in folk medicine for the treatment of common cold, flu, and upper respiratory infections and also as an immune system booster. Steroids, flavonoids, and triterpenes, gossypin alkaloids have been isolated from the whole part of the plant. In the present study, the methanolic extract of dried plant of Fioria vitifolia (MEFV) was investigated for anti-inflammatory (carrageenan induced rat paw oedema) and anti-pyretic (brewers yeast induced pyrexia) activities. Pre-treatment with the extract (250-500mg/ kg, p. o) significantly prevented increase in volume of paw oedema in dose dependent manner. A maximal effect was observed at 500mg/kg which was comparable to diclofenac (20mg/kg, orally). Ceiling effect at the dose of 500mg/kg was observed. The anti-pyretic effect of MEFV (measured as % reduction in body temperature) was compared with paracetamol (150mg/kg, orally). MEFV in dose of 500mg/kg caused significant decrease in body temperature of rats. In conclusion, this study has established the anti-inflammatory activity and anti pyretic activity of Fioria vitifolia and thus, justifies the ethnicuses of the plant.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15154 International Current Pharmaceutical Journal, June 2013, 2(7): 119-121
Antifungal properties of selected plants of Apocynaceae family against the human fungal pathogen Candida albicans
Authors: Wankhede Savita Bajrang , Routh Madhushree Madhumita , Rajput Sandeep Balsingh , Karuppayil Sankuny Mohan 
Published: June 2013

The ethnobotanical evaluation of plant based chemicals has proven themselves greatly in last few decades. Plants have been a rich source of therapeutic agents and form the basis of traditional medicine system. On the basis of this, in vitro antifungal activities of extracts of Catharanthus roseus, Nerium oleander and Taberenemontana divaricata leaf extracts were evaluated in the present study by 96 well microtiter plate assays using human fungal pathogen Candida albicans ATCC90028 strain. The activity was measured by spectophotometric methods to determine the Minimum Inhibitory Concentration (MIC). The Minimum Fungicidal Concentrations (MFC) for the extracts was also determined by a plate assay. The distilled water extract, petroleum ether extract, methanolic extract, ethyl acetate extract and sequential distilled water leaf extracts of all the plants showed potential activity against C. albicans ATCC 90028. The study ascertains the value of Apocynaceae plants, which could be of considerable interest to the development of new safer antifungals.DOI: http://dx.doi.org/10.3329/icpj.v2i7.15155 International Current Pharmaceutical Journal, June 2013, 2(7): 122-125
Serum Pyridinoline Levels and Prediction of Severity of Joint Destruction in Rheumatoid Arthritis
Authors: Krabben Annemarie , Knevel Rachel , Huizinga Tom W.J. , Cavet Guy , van der Helm-van Mil Annette H.M. 
Published: June 2013

Objective.Previous studies indicated that pyridinoline, a collagen crosslink in cartilage and bone, might be a good marker to predict joint destruction in patients with rheumatoid arthritis (RA), although large prospective studies are lacking. We evaluated the predictive value of serum pyridinoline levels for joint destruction, both at baseline for longterm prediction and during the disease course for near-term prediction.Methods.Patients with early RA from the Leiden Early Arthritis Clinic were studied. Radiographs at baseline and yearly during 7 years of followup were scored according to the Sharp-van der Heijde Scoring (SHS) method. Pyridinoline serum levels at baseline and during followup were measured by ELISA. The association between baseline pyridinoline levels and difference in SHS over 7 years was tested, with a multivariate normal regression model. Second, the association between pyridinoline levels determined during the disease course and progression of SHS over the next year was tested with a multivariable linear regression analysis.Results.Studying baseline pyridinoline serum levels in 437 patients revealed that the mean SHS over 7 years was 6% higher for every higher pyridinoline level (nmol/l) at baseline (p = 0.001). Subsequently, during followup (n = 184 patients) the progression in SHS in the upcoming year was 17% higher for every higher nmol/l pyridinoline level (p = 0.001). The area under the receiver-operation characteristic curve for rapid radiological progression was 0.59.Conclusion.Increased pyridinoline serum levels, both at baseline and during the disease course, are associated with more severe joint destruction during the coming year(s), although the predictive accuracy as a sole predictor was moderate.