bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Prognostic Value of Active Otitis Media on Tympanoplasty Success Rate—A Systematic Review
Authors: Namba Hanae Fumiyo , Plug Mariëlle Bernadette , Smit Adriana Leni 
Published: July 2024

ABSTRACTObjectivesThe aim is to investigate the influence of an active otitis media on the success rate of tympanoplasty in patients with a chronic otitis media (COM) and a tympanic membrane perforation.Databases ReviewedPubMed, Embase and the Cochrane Library.MethodsThe inclusion criteria were studies on closure rates of tympanoplasty performed in COM patients of any age with a tympanic membrane perforation caused by COM. The exclusion criteria were studies on patients undergoing concomitant mastoidectomy, ossicular chain reconstruction, tuboplasty, adenoidectomy, revision tympanoplasty, patients with perforations due to other conditions than COM, and letters to editors, commentaries, conference abstracts and case reports. The included articles were critically appraised using the QUIPS tool. Data on tympanic membrane closure rate were extracted, odds ratio (OR) and 95% confidence intervals (CI) of the closure rate with a wet versus a dry ear were calculated.ResultsThe search was performed on 1 February 2023. Of 4671 articles, 16 studies were included and critically appraised. Of these observational studies (nine prospective, seven retrospective), with a total of 1509 patients (dry ear group n = 1003; wet ear group n = 506), two studies stated a significant difference in success rate, one in favour of a dry ear and one in favour of a wet ear at time of surgery. All other studies did not show a statistically significant difference. Overall, the risk of bias was considered moderate to high.ConclusionsWe found no significant prognostic value of having an active otitis media during tympanoplasty on tympanic membrane closure rates. Because the overall risk of bias was considered moderate to high, no strong conclusions can be made. To be able to answer this question with higher levels of evidence, high‐quality prospective or randomized studies are needed.
Lexical and Social Effects on the Learning and Integration of Inflectional Morphology
Authors: Rácz Péter , Lukács Ágnes 
Published: July 2024

AbstractPeople learn language variation through exposure to linguistic interactions. The way we take part in these interactions is shaped by our lexical representations, the mechanisms of language processing, and the social context. Existing work has looked at how we learn and store variation in the ambient language. How this is mediated by the social context is less understood.We report on the results of an innovative experimental battery designed to test how learning variation is affected by a variable's social indexicality. Hungarian native speakers played a co‐operative game involving verb nonwords. These were built on existing inflectional variation in Hungarian. Participant behavior shifted in response to an automated co‐player's preferences, and this reflected a change in the overall lexical patterns of the players, affected by the particular verbs introduced by the co‐player. Patterns persisted in subsequent testing. Learning was similar for variables with or without social meaning.Results show that participants can learn and retain a range of variable morphological patterns in a simulated interaction. Participants seem to have equal capacity to pick up variables with and without social meaning. This suggests that the social meaning of a pattern does not clearly constrain learning morphological variation and becomes relevant downstream in learning.
Pharmacogenomics polygenic risk score: Ready or not for prime time?
Authors: Singh Sonal , Stocco Gabriele , Theken Katherine N. , Dickson Alyson , Feng QiPing , Karnes Jason H. , Mosley Jonathan D. , El Rouby Nihal 
Published: July 2024

AbstractPharmacogenomic Polygenic Risk Scores (PRS) have emerged as a tool to address the polygenic nature of pharmacogenetic phenotypes, increasing the potential to predict drug response. Most pharmacogenomic PRS have been extrapolated from disease‐associated variants identified by genome wide association studies (GWAS), although some have begun to utilize genetic variants from pharmacogenomic GWAS. As pharmacogenomic PRS hold the promise of enabling precision medicine, including stratified treatment approaches, it is important to assess the opportunities and challenges presented by the current data. This assessment will help determine how pharmacogenomic PRS can be advanced and transitioned into clinical use. In this review, we present a summary of recent evidence, evaluate the current status, and identify several challenges that have impeded the progress of pharmacogenomic PRS. These challenges include the reliance on extrapolations from disease genetics and limitations inherent to pharmacogenomics research such as low sample sizes, phenotyping inconsistencies, among others. We finally propose recommendations to overcome the challenges and facilitate the clinical implementation. These recommendations include standardizing methodologies for phenotyping, enhancing collaborative efforts, developing new statistical methods to capitalize on drug‐specific genetic associations for PRS construction. Additional recommendations include enhancing the infrastructure that can integrate genomic data with clinical predictors, along with implementing user‐friendly clinical decision tools, and patient education. Ethical and regulatory considerations should address issues related to patient privacy, informed consent and safe use of PRS. Despite these challenges, ongoing research and large‐scale collaboration is likely to advance the field and realize the potential of pharmacogenomic PRS.
The Bethesda System for Reporting Thyroid Cytopathology in the African American population: A tertiary centre experience
Authors: Saoud Carla , Bailey Gabrielle E. , Graham Ashleigh J. , Maleki Zahra 
Published: July 2024

AbstractBackgroundThe reported risk of malignancies (ROM) remains controversial for fine needle aspiration (FNA) of thyroid nodules in the African American (AA) population. Herein, the ROM along with frequency was assessed for each of the Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) diagnostic categories.Materials and MethodsThe electronic pathology archive of a large academic hospital was retrospectively searched for cytopathology reports of thyroid nodules in AA patients (2010–2019) and Non‐African American (NAA) control cases. The patients' demographic, thyroid nodule characteristics, FNA results using TBSRTC and surgical diagnoses were recorded, whenever available.ResultsThree hundred ninety‐one cases were identified, 317 females (81.1%) and 74 males (18.9%) with median age 50.0 (SD = 14.4). The mean size of the nodules was 2.1 cm (SD = 1.4). The Bethesda categories were: 5.4% (I), 35.0% (II), 35.3% (III), 7.7% (IV), 3.3% (V) and 13.3% (VI). The overall ROM of thyroid nodules was 43.8% (89/203) on surgical follow‐up (203/391). The ROM in each Bethesda categories were: 33.3% (I), 11.6% (II), 35.2% (III), 15.8% (IV), 83.3% (V) and 100% (VI) on surgical follow‐up. The frequency of thyroid nodules was higher in AA females; however, the ROM was higher in AA males (48.3%) compared with AA females (41.2%).ConclusionThe ROM in Categories I, II and III was higher than those reported in the TBSRTC while being similar in Categories IV, V and VI. The overall risk of thyroid malignancy in our AA patient population was higher than those in the literature. The overall ROM of thyroid nodules in AA males was higher than of AA females.
Modelling the interaction between EFL teachers' personality traits, emotion regulation strategies, and teachers' depression: A structural equation approach
Authors: Qu Jingfeng , Wang Yongliang 
Published: July 2024

AbstractEmotion regulation strategies can enhance teachers' well‐being and performance by enabling them to cope with the challenges and stressors of teaching. Personality traits, however, may affect teachers' vulnerability to depression and their capacity to regulate their emotions. To investigate how emotion regulation strategies mediated the relationship between EFL teachers' personality traits and depression, we invited 546 Chinese EFL teachers to complete the relevant online questionnaires. The Structural Equation Modelling (SEM) results revealed that teachers' personality traits directly influenced their depression levels, and that their depression levels negatively impacted their emotion regulation strategies. Furthermore, the results demonstrated that positive emotions mediated the relationship between teachers' personality traits and depression, suggesting that teachers with higher levels of positive emotions had lower levels of depression and more effective emotion regulation strategies. The findings implied that fostering positive emotions and emotion regulation strategies can improve teachers' mental health and teaching quality. The study also added to the knowledge of the role of emotion regulation strategies in the interplay between personality traits and depression.
New insights on the chromosomal inversion thermal adaptation in insects: American populations of Drosophila subobscura
Authors: Arenas Concepció , Zivanovic Goran , Pegueroles Cinta , Mestres Francesc 
Published: July 2024

AbstractDrosophila subobscura is an excellent model species for testing genetic variation in thermal adaptation due to its rich inversion chromosomal polymorphism. In Palearctic populations, the inversions of this species can be classified as “cold”, “warm” or “nonthermal” adapted. Based on this classification the Chromosomal Thermal Index (CTI) was developed, which allows measuring the thermal adaptation of populations and monitoring changes over time. Here, we aim to use this index in American colonizing populations of D. subobscura for the first time to obtain new information on the species thermal adaptation. Thus, thermal adapted inversions (“cold” and “warm”) were defined for the American continent and CTI was computed in South American (1981 and 1999 samples) and North American (1985 and 2004 samples) populations of D. subobscura. In general, both American populations showed an inverse relationship between CTI values and latitude, with CTI values decreasing when latitude increases. When comparing populations sampled in different years, an increase in CTI values was detected in four out of six temporal comparisons (only one was significant) of South America (1981 and 1999) and in six out of seven populations of North America (1985 and 2004). A global analysis using a one‐way repeated measures anova of CTI values in both American hemispheres showed a trend of increase for “warm” adapted inversions in Chile and North America, but this increase was only significant for the latter. Overall, these results are in agreement with global warming expectations, although natural selection acted differently in the colonized hemispheres.
Wound area severity index (WASI): A novel tool for assessing and predicting healing times in hidradenitis suppurativa postsurgical wounds
Authors: Michelucci Alessandra , Manzo Margiotta Flavia , Innocenti Silvia , Vietina Antonella , Granieri Giammarco , Janowska Agata , Morganti Riccardo , Romanelli Marco , Dini Valentina 
Published: July 2024

AbstractHidradenitis suppurativa (HS) presents challenges in management due to its chronic nature and high risk of recurrence. Post‐surgical wound care plays a crucial role in treatment, even if standardized methods for assessing and predicting healing times are lacking. The aim of the study is to introduce the Wound Area Severity Index (WASI) as a novel tool to guide clinicians in assessing postsurgical wound progression and predicting potential healing times. A team of wound healing experts assessed 93 post‐surgical HS wounds resulting from wide excision and secondary intention healing. For each wound healing time, wound area, wound bed score (WBS), and WASI were evaluated. WASI includes four parameters: area, temperature, depth and wound Bed, each with four severity levels. The total WASI score ranges from 4 to 16. Spearman correlation and Kruskal–Wallis tests were employed for statistical analysis. WASI strongly correlated with wound healing time (rho: 0.813, p < 0.001). Higher WASI scores were associated with prolonged healing, while lower scores indicated almost healed wounds. The WASI score has proven to be more highly predictive of healing times when compared to the individual parameter of the Area (moderate positive correlation, r: 0.77) and the WBS (negative correlation, r: −0.72). A total WASI score of 4 corresponded to a median healing time of 7 days, while a score exceeding 9 suggested a median healing time of 56 days. WASI has proven to be a valuable tool for assessing and predicting healing times in post‐surgical HS wounds. Its simplicity, cost‐effectiveness, and ability to integrate multiple parameters make it a promising addition to wound care practice.
Quantitative comparison of immunohistochemical HER2‐low detection in an interlaboratory study
Authors: Hempenius Maaike Anna , Eenkhoorn Maran A , Høeg Henrik , Dabbs David J , van der Vegt Bert , Sompuram Seshi R , ‘t Hart Nils A 
Published: July 2024

AimsRecently, human epidermal growth factor 2 (HER2)‐low (i.e. HER2 score 1+ or 2+ without amplification) breast cancer patients became eligible for trastuzumab–deruxtecan treatment. To improve assay standardisation and detection of HER2‐low in a quantitative manner, we conducted an external quality assessment‐like study in the Netherlands. Dynamic range cell lines and immunohistochemistry (IHC) calibrators were used to quantify HER2 expression and to assess interlaboratory variability.Methods and resultsThree blank slides with a dynamic range cell line and an IHC calibrator were stained with routine HER2 assays by 35 laboratories. Four different antibody clones were used: 19 (54.3%) 4B5, six (17.1%) A0485, five (14.3%) DG44 (HercepTest) and five (14.3%) SP3. Laboratories used two different detection kits for 4B5 assays: 14 (73.7%) ultraView and five (26.3%) OptiView. Variability of HER2 expression in cell lines, measured with artificial intelligence software, was median (min–max) = negative core 0.5% (0.0–57.0), 1+ core 4.3% (1.6–71.3), 2+ core 42.8% (30.4–92.6) and 3+ core 96.2% (91.8–98.8). The calibrators DG44 and 4B5 OptiView had the highest analytical sensitivity, closely followed by 4B5 ultraView. SP3 was the least sensitive. Calibrators of A0485 assays were not analysable due to background staining.ConclusionsAs assays were validated for detecting HER2‐amplified tumours, not all assays and antibodies proved suitable for HER2‐low detection. Some tests showed distinct expression in the negative cell line. Dynamic range cell line controls and quantitative analysis using calibrators demonstrated more interlaboratory variability than commonly appreciated. Revalidation of HER2 tests by laboratories is needed to ensure clinical applicable HER2‐low assays.
User perception of fluoride mouthwashes for daily use: A randomized clinical trial
Authors: Toonen L. S. J. , van Swaaij B. W. M. , Timmerman M. F. , Van der Weijden Fridus (G. A.) , Slot D. E. 
Published: July 2024

AbstractAimTo assess user perceptions of different commercially available fluoride mouthwashes (FL‐MWs).MethodsA single‐blind, randomized clinical trial was conducted. Participants were randomly assigned to a sequence of six different FL‐MWs, one of which contained alcohol. For each visit, participants rinsed with one specific mouthwash (15 mL) for 30 s. After rinsing, participants completed a questionnaire with a visual analogue scale. Questions focused on overall taste, mild/pungent feeling, taste duration, foaming effect, burning sensation, sensitivity, numbness, dryness, rinsing time, smell, and colour of the mouthwashes. Descriptive analyses and statistical tests regarding differences among and between the mouthwashes were performed.ResultsOverall, 53 participants completed the study protocol, including nine who did, however, not rinse with the alcohol‐containing mouthwash due to religious reasons. Among the mouthwashes, significant differences were found for foaming effect, sensitivity, rinsing time, smell, and colour (p < 0.05). Pairwise comparison for smell did not reveal a difference, and foaming was within the acceptance range (low to medium foaming). Coloured mouthwashes were more appreciated than transparent solutions (p = 0.00). The mouthwash containing essential oils and alcohol produced significantly more sensitivity (p = 0.00) and, in general, participants experienced the rinsing time significantly longer (p < 0.05) compared to the non‐alcohol‐containing mouthwashes.ConclusionThere is heterogeneity in user perceptions and preferences for FL‐MWs, with a significant difference in foaming effect, sensitivity, rinsing time, smell, and colour. Coloured mouthwashes are preferred. The mouthwash containing essential oils and alcohol was less acceptable in relation to sensitivity and rinsing time.
THE UNPRECEDENTED FALL IN U.S. REVOLVING CREDIT
Authors: Raveendranathan Gajendran , Stefanidis Georgios 
Published: July 2024

AbstractAfter decades of consistent growth, U.S. revolving credit declined drastically post 2009. We study the Ability to Pay provision of the Credit CARD Act of 2009, a policy that restricts credit card limits, as a contributing factor. Extending a model of revolving credit lines, we find that the policy accounts for 54–60% of the decline in revolving credit. Furthermore, the policy accounts for lower utilization rates despite tighter credit limits and higher spreads despite lower default risk. The policy's goal of consumer protection is achieved for a few consumers with time‐inconsistent preferences; most individuals are hurt.
Detection of hidden bruises on kiwifruit using hyperspectral imaging combined with deep learning
Authors: Bu Youhua , Luo Jianing , Li Jiabao , Chi Qian , Guo Wenchuan 
Published: July 2024

SummaryDuring harvesting, transportation and storage of kiwifruit, the flesh is often bruised by collision or compression. However, the bruises in kiwifruit are extremely difficult to recognise by naked eyes and are called hidden bruises. Accordingly, a fast method for detecting hidden bruises in kiwifruit was developed in this study based on hyperspectral imaging (HSI) coupled with deep learning. The spectral range (924–1277 nm) and feature wavelengths (928.19, 1051.03 and 1190.47 nm) sensitive to hidden bruises in kiwifruit were selected using the principal component analysis (PCA). Subsequently, three‐channel images (Dataset 1), grayscale images (Dataset 2) and pseudo‐colour images (Dataset 3) were generated according to the images of feature wavelengths of the kiwifruit. The YOLOv5s model for detecting the hidden bruised areas of the kiwifruit was developed using these three datasets. The results showed that the YOLOv5s detection model performed best at Dataset 1, and the values of Precision, Recall, F1, mAP and FNR of this model were 98.25%, 97.50%, 97.87%, 99.12% and 2.50% respectively. The study showed that HSI technology combined with the YOLOv5s model can effectively detect hidden bruises in kiwifruit, providing references for detecting hidden bruises in other fruit.
Preparation and characterisation of fish skin collagen–chitosan–cinnamon essential oil composite film
Authors: Mao Qian , Zhuo Yijia , Luo Song , Li Jiahui , Hu Fengqing , Zhao Qi 
Published: July 2024

SummaryThe composite film with collagen as the main component has been widely used due to its characteristics of non‐toxicity, environmental protection and health. Fish skin, a by‐product of fish, is an excellent source of collagen. Thus, collagen was extracted from an under‐utilised species, Atlantic cod (Gadus morhua) skin, and the composite film of fish skin collagen–chitosan–cinnamon essential oil was prepared by casting. The effects of the ratio of collagen to chitosan (2:8, 4:6, 5:5, 6:4, 8:2) and the concentration of essential oil (0%, 0.1%, 0.2%, 0.3%, and 0.4% (v/v)) on the composite film were studied. The structures of the composite films were analysed using scanning electron microscopy (SEM), Fourier transforms infrared spectroscopy (FTIR), and X‐ray diffractometry (XRD). The collagen content of Atlantic cod skin is approximately 50.12%, which is significantly higher than that found in basa fish and Nile tilapia (P < 0.05). The content of hydroxyproline was 4.51%. Analyses of tensile strength, elongation at break, water vapor permeability, and water solubility showed Co4Ch6 (Co:Ch = 4:6) had the optimal comprehensive performance, and Co4Ch6–0.2 (Co4Ch6 with 0.2% CEO) had high water resistance in the high‐humidity environment. As the CEO concentration rose, the composite films' infrared absorption bands were enhanced in amplitude, and the XRD peaks were gradually intensified, indicating the internal crystallinity and, thereby, the opacity of the composite films were improved. The bacteriostasis zones Co4Ch6–0.4 against Escherichia coli and Staphylococcus aureus were 2.02 cm and 1.73 cm, respectively. The DPPH radical scavenging rate of Co4Ch6 rose with the increase in CEO concentration, and the DPPH radical scavenging rate of C04Ch6–0.4 was up to 48.56%. Thus, the composite films prepared from fish skin collagen, chitosan, and cinnamon essential oils have outstanding mechanical properties, barrier ability, and antimicrobial activity and are promising for application in food packaging and storage. In addition, the composite films showed a potential antioxidation ability, which might be used as green bioactive films to preserve nutraceutical products.
Neurological‐related proteomic profiling in plasma of children with metabolic healthy and unhealthy overweight/obesity
Authors: Olvera‐Rojas Marcos , Plaza‐Florido Abel , Solis‐Urra Patricio , Osuna‐Prieto Francisco J. , Ortega Francisco B. 
Published: July 2024

SummaryObjectiveChildren with overweight/obesity (OW/OB) exhibit poor cardiometabolic health, yet mechanisms influencing brain health remain unclear. We examined the differences in neurological‐related circulating proteins in plasma among children with metabolically healthy obesity (MHO) and metabolically unhealthy obesity (MUO) and the association with metabolic syndrome markers.MethodsIn this cross‐sectional study, we included 84 Caucasian children (39% girls), aged 10.1 ± 1.1 years, from the ActiveBrains project (NCT02295072). A ninety‐two‐protein targeted approach using Olink's® technology was used.ResultsWe identified distinct concentrations of CD38, LAIR2, MANF and NRP2 proteins in MHO compared with MUO. Moreover, individual metabolic syndrome (MS) markers were linked to nine proteins (CD38, CPM, EDA2R, IL12, JAMB, KYNU, LAYN, MSR1 and SMOC2) in children with OW/OB. These proteins play crucial roles in diverse biological processes (e.g., angiogenesis, cholesterol transport, nicotinamide adenine dinucleotide (NAD+) catalysis and maintenance of blood–brain barrier) related to brain health.ConclusionOur proteomics study suggests that cardiometabolic health (represented by MHO/MUO or individual MS markers) is associated with the concentration in plasma of several proteins involved in brain health. Larger‐scale studies are needed to contrast/confirm these findings, with CD38 standing out as a particularly noteworthy and robust discovery.