bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global Distribution of the Skill of Tropical Cyclone Activity Forecasts on Short- to Medium-Range Time Scales
Authors: Yamaguchi Munehiko , Vitart Frédéric , Lang Simon T. K. , Magnusson Linus , Elsberry Russell L. , Elliott Grant , Kyouda Masayuki , Nakazawa Tetsuo 
Published: September 2015

AbstractOperational global medium-range ensemble forecasts of tropical cyclone (TC) activity (genesis plus the subsequent track) are systematically evaluated to understand the skill of the state-of-the-art ensembles in forecasting TC activity as well as the relative benefits of a multicenter grand ensemble with respect to a single-model ensemble. The global ECMWF, JMA, NCEP, and UKMO ensembles are evaluated from 2010 to 2013 in seven TC basins around the world. The verification metric is the Brier skill score (BSS), which is calculated within a 3-day time window over a forecast length of 2 weeks to examine the skill from short- to medium-range time scales (0–14 days). These operational global medium-range ensembles are capable of providing guidance on TC activity forecasts that extends into week 2. Multicenter grand ensembles (MCGEs) tend to have better forecast skill (larger BSSs) than does the best single-model ensemble, which is the ECMWF ensemble in most verification time windows and most TC basins. The relative benefit of the MCGEs is relatively large in the north Indian Ocean and TC basins in the Southern Hemisphere where the BSS of the single-model ensemble is relatively small. The BSS metric and the reliability are found to be sensitive to the choice of threshold wind values that are used to define the model TCs.
Discovering the hidden benefits of cognitive interviewing in two languages: The first phase of a validation study of the Integrated Palliative care Outcome Scale
Authors: Schildmann Eva K , Groeneveld E Iris , Denzel Johannes , Brown Alice , Bernhardt Florian , Bailey Katharine , Guo Ping , Ramsenthaler Christina , Lovell Natasha , Higginson Irene J , Bausewein Claudia , Murtagh Fliss EM 
Published: September 2015

Background: The Integrated Palliative care Outcome Scale is a newly developed advancement of the Palliative care Outcome Scale. It assesses patient-reported symptoms and other concerns. Cognitive interviewing is recommended for questionnaire refinement but not adopted widely in palliative care research. Aim: To explore German- and English-speaking patients’ views on the Integrated Palliative care Outcome Scale with a focus on comprehensibility and acceptability, and subsequently refine the questionnaire. Methods: Bi-national (United Kingdom/Germany) cognitive interview study using ‘think aloud’ and verbal probing techniques. Interviews were audio-recorded, transcribed verbatim and analysed using thematic analysis and pre-defined categories. Results from both countries were collated and discussed. The Integrated Palliative care Outcome Scale was then refined by consensus. Setting/participants: Purposely sampled patients from four palliative care teams in palliative care units, general hospital wards and in the community. Results: A total of 15 German and 10 UK interviews were conducted. Overall, comprehension and acceptability of the Integrated Palliative care Outcome Scale were good. Identified difficulties comprised the following: (1) comprehension problems with specific terms (e.g. ‘mouth problems’) and length of answer options; (2) judgement difficulties, for example, due to the 3-day recall for questions; and (3) layout problems. Combining the results from both countries (e.g. regarding ‘felt good about yourself’) and discussing them from both languages’ perspectives resulted in wider consideration of the items’ meaning, enabling more detailed refinement. Conclusion: Cognitive interviewing proved valuable to increase face and content validity of the questionnaire. The concurrent approach in two languages – to our knowledge the first such approach in palliative care – benefited the refinement. Psychometric validation of the refined Integrated Palliative care Outcome Scale is now underway.
Improving Caregivers’ Perceptions Regarding Patient Goals of Care/End-of-Life Issues for the Multidisciplinary Critical Care Team
Authors: Wessman Brian T. , Sona Carrie , Schallom Marilyn 
Published: September 2015

Objective: With population aging and growth, use of critical care medicine at the end of life continues to rise, while many critical care providers are not adequately trained regarding goals of care/end-of-life (GOC/EOL) issues. A multidisciplinary intensive care unit (ICU) team intervention regarding GOC/EOL communication will enhance the clinical abilities of all critical care providers when discussing GOC/EOL issues and increase ICU staff comfort level while improving transitions for patients to a comfort care approach. Design: This study was a preintervention/postintervention survey evaluation. Setting: This study was conducted at an academic tertiary surgical burn trauma ICU. Population: The intervention was provided to nursing, ancillary staff, house staff, and attending physicians. Intervention: An initial survey was circulated among the critical care staff for baseline expectations, satisfaction, and understanding of GOC/EOL care. A robust intervention was begun including the creation of a multidisciplinary GOC/EOL team, communication tools for providers, patient–family pamphlets, standardized EOL order sets, and formalized didactic sessions. Subsequently, the same survey was circulated and compared to baseline data. Measurements: Preintervention/postintervention survey data were reviewed and statistically analyzed. Main Results: Our survey response rate for preintervention/postintervention was 50.4% and 36.1%, respectively. The intervention generated heightened interest in improving family communication and provided focal direction to foster this growth. Based on the serial surveys regarding our intervention, statistically significant staff improvements were seen in “work stress” ( P = .04), “EOL information” ( P = .006), and “space allotment” ( P = .001). Improved congruence of families and health care providers regarding decision over intensity of care was also noted. Conclusion: We created a novel unit-based multidisciplinary program for improved EOL/GOC approaches in the critical care setting. A similarly formatted program could be adapted by other ICUs. Benefits of such a program include improving caregivers’ perceptions regarding EOL/GOC issues and fostering critical care team growth.
Anti-Immigrant Anxieties in State Policy: The Great Recession and Punitive Immigration Policy in the American States, 2005–2012
Authors: Ybarra Vickie D. , Sanchez Lisa M. , Sanchez Gabriel R. 
Published: September 2015

AbstractThe Great Recession of late 2007 through 2009 had profound negative economic impacts on the U.S. states, with 49 states experiencing revenue decreases in their 2009 budgets representing more than $67.2 billion USD. Also during this period, states enacted a record number of laws related to immigrants residing in their states. We make use of data from the National Conference of State Legislatures (NCSL) to examine punitive immigration policy enactment from 2005 to 2012 and conduct a state comparative study using cross-sectional time-series analysis to examine the potential ways in which the economic recession and changing demographics in the states have impacted punitive state immigration policy making. We hypothesize that although anti-immigrant anxieties are driven in part by economic insecurity, they are also impacted by the presence of a large or growing proportion of racialized immigrants. We find that increases in state Hispanic populations and state economic stressors associated with the recession have both led to a greater number of enacted punitive state immigration policies. In addition, we find that changes in the non-Hispanic white populations in the states are also impacting the expression of anti-immigrant attitudes in state policy during this period.
Combined laparoscopic pyelolithotomy and endoscopic pyelolithotripsy for staghorn calculi: long-term follow-up results from a case series
Authors: Pastore Antonio Luigi , Palleschi Giovanni , Silvestri Luigi , Leto Antonino , Ripoli Andrea , Fuschi Andrea , Al Salhi Yazan , Autieri Domenico , Petrozza Vincenzo , Carbone Antonio 
Published: September 2015

Purpose: Staghorn renal stones are a challenging field in urology. Due to their high recurrence rates, particularly those associated with an infective process, a complete removal is the ultimate goal in their management. We report our experience with a combined approach of laparoscopic pyelolithotomy and endoscopic pyelolithotripsy, the stone clearance rate, and long-term, follow-up outcomes. Methods: From June 2012 to October 2014, nine adult patients with large staghorn renal calculi (mean size, 7.2 cm; range, 6.2–9.0 cm) underwent a combined laparoscopic and endoscopic approach. The technique comprised laparoscopic pyelolithotomy and holmium-YAG laser stone fragmentation with the use of a flexible cystoscope introduced through a 12 mm trocar. Results: The average operative time was 140 min (range, 90–190 min). The mean estimated hemoglobin loss was 0.6 mmol/l (range 0.5–0.7 mmol/l). None of the patients required an open- surgery conversion. The mean hospital stay was 4 days (range, 2–6 days). A computed tomography urogram control at 6 months of follow up did not show any stone recurrence. Conclusions: Laparoscopic pyelolithotomy combined with endoscopic pyelolithotripsy could be a therapeutic option in cases where mini-invasive procedures, that is, extracorporeal shock wave lithotripsy, ureteroscopic lithotripsy, and percutaneous nephrolithotomy (PCNL) have failed. This technique has a high stone-clearance rate (75–100%) comparable with open surgery and PCNL. However, it could be technically demanding and should be performed by skilled laparoscopy surgeons.
Evaluation of an integrated multidisciplinary approach in multiple sclerosis care: A prospective, randomized, controlled study
Authors: Papeix Caroline , Gambotti Laetitia , Assouad Rana , Ewenczyck Claire , Tanguy Marie-Laure , Pineau Fanny , Houis Marie-Claire , Mazevet Dominique , Maillart Elisabeth , Lubetzki Catherine 
Published: September 2015

Background Disabled multiple sclerosis (MS) patients often need intervention of multiple specialists, resulting in a complex organization of care. How this multidisciplinary care should be organized and structured has not been studied. Objective The objective of this article is to address the effectiveness of an integrated multidisciplinary approach versus usual care in MS patients. Methods This is a prospective, randomized, controlled, monocentric clinical trial in MS patients. Two treatment strategies were compared: (i) an integrated multidisciplinary (IMD) approach, consisting of a half-day individually tailored comprehensive assessment in the MS clinic; and (ii) a standard care. The primary outcome was the impact of the strategy on quality of life (QoL) measured using the MSIS-29 scale at inclusion and after six months. Results Fifty MS patients were included. Median MSIS 29 score decreased over six months in the control group (−4.89) and increased in the IMD group (+2.00), with a significant difference between the two groups ( p = 0.03). However, in the multivariate analysis, after adjustment of HAD-D and INTERMED score, this difference was no longer significant. Conclusions This prospective, randomized study is the first attempt to evaluate the multidisciplinary approach in MS patients. The results show that, contrary to our expectations, an integrated multidisciplinary approach is not superior to usual care on QoL.
Metallogeny of the North Atlantic Craton in Greenland
Authors: Kolb Jochen , Bagas Leon , Fiorentini Marco L. 
Published: September 2015

AbstractThe North Atlantic Craton (NAC) extends along the coasts of southern Greenland. At its northern and southern margins, Archaean rocks are overprinted by Palaeoproterozoic orogeny or overlain by younger rocks. Typical granite-greenstone and granite-gneiss complexes represent the entire Archaean, with a hiatus from ∼3.55–3.20 Ga. In the granulite- and amphibolite-facies terranes, the metallogeny comprises hypozonal orogenic gold and Ni-PGE-Cr-Ti-V in mafic-ultramafic magmatic systems. Gold occurrences are widespread around and south of the capital, Nuuk. Nickel mineralization in the Maniitsoq Ni project is hosted in the Norite belt; Cr and PGE in Qeqertarssuatsiaq, and Ti-V in Sinarsuk in the Fiskenæsset complex. The lower-grade metamorphic Isua greenstone belt hosts the >1000 Mt Isua iron deposit in an Eoarchaean banded iron formation. Major Neoarchaean shear zones host mesozonal orogenic gold mineralization over considerable strike length in South-West Greenland. The current metallogenic model of the NAC is based on low-resolution data and variable geological understanding, and prospecting has been the main exploration method. In order to generate a robust understanding of the metal endowment, it is necessary to apply an integrated and collective approach. The NAC is similar to other well-endowed Archaean terranes but is underexplored, and is therefore likely to host numerous targets for greenfields exploration.
Sm-Nd and Lu-Hf isotope and trace-element systematics of Mesoarchaean amphibolites, inner Ameralik fjord, southern West Greenland
Authors: Szilas Kristoffer , Hoffmann J. Elis , Hansmeier Christina , Hollis Julie A. , Münker Carsten , Viehmann Sebastian , Kasper Haino U. 
Published: September 2015

AbstractFragmented supracrustal rocks are typical components of Archaean high-grade gneiss terranes, such as those in the North Atlantic Craton. Here we present the first major, trace element and Nd-Hf isotope data for amphibolites collected in the yet poorly studied southern inner Ameralik fjord region of southern West Greenland. In addition, new U-Pb zircon ages were obtained from the surrounding TTG gneisses.Based on their trace-element patterns, two different groups of amphibolites can be distinguished. Following screening for post-magmatic alteration and outlying ε values, a reduced sample set defines a147Sm/143Nd regression age of 3038 Ma ±310 Ma (MSWD = 9.2) and a176Lu/176Hf regression age of 2867 ±160 Ma (MSWD = 5.5). Initial εNd2970Mavalues of the least-altered amphibolites range from 0.0 to +5.7 and initial εHf2970Ma range from +0.7 to +10.4, indicating significant isotopic heterogeneity of their mantle sources with involvement of depleted domains as well as crustal sources.Surprisingly, the amphibolites which are apparently most evolved and incompatible element-rich have the most depleted Hf-isotope compositions. This apparent paradox may be explained by the sampling of a local mantle source region with ancient previous melt depletion, which was re-enriched by a fluid component during subduction zone volcanism or alternatively by preferential melting of an ancient pyroxenite component in the mantle source of the enriched rocks.
Life habits, hox genes, and affinities of a 311 million-year-old holometabolan larva
Authors: Haug Joachim T. , Labandeira Conrad C. , Santiago-Blay Jorge A. , Haug Carolin , Brown Susan 
Published: September 2015

Abstract
Background
Holometabolous insects are the most diverse, speciose and ubiquitous group of multicellular organisms in terrestrial and freshwater ecosystems. The enormous evolutionary and ecological success of Holometabola has been attributed to their unique postembryonic life phases in which nonreproductive and wingless larvae differ significantly in morphology and life habits from their reproductive and mostly winged adults, separated by a resting stage, the pupa. Little is known of the evolutionary developmental mechanisms that produced the holometabolous larval condition and their Paleozoic origin based on fossils and phylogeny.

Results
We provide a detailed anatomic description of a 311 million-year-old specimen, the oldest known holometabolous larva, from the Mazon Creek deposits of Illinois, U.S.A. The head is ovoidal, downwardly oriented, broadly attached to the anterior thorax, and bears possible simple eyes and antennae with insertions encircled by molting sutures; other sutures are present but often indistinct. Mouthparts are generalized, consisting of five recognizable segments: a clypeo-labral complex, mandibles, possible hypopharynx, a maxilla bearing indistinct palp-like appendages, and labium. Distinctive mandibles are robust, triangular, and dicondylic. The thorax is delineated into three, nonoverlapping regions of distinctive surface texture, each with legs of seven elements, the terminal-most bearing paired claws. The abdomen has ten segments deployed in register with overlapping tergites; the penultimate segment bears a paired, cercus-like structure. The anterior eight segments bear clawless leglets more diminutive than the thoracic legs in length and cross-sectional diameter, and inserted more ventrolaterally than ventrally on the abdominal sidewall.

Conclusions
Srokalarva berthei occurred in an evolutionary developmental context likely responsible for the early macroevolutionary success of holometabolous insects. Srokalarva berthei bore head and prothoracic structures, leglet series on successive abdominal segments – in addition to comparable features on a second taxon eight million-years-younger – that indicates Hox-gene regulation of segmental and appendage patterning among earliest Holometabola. Srokalarva berthei body features suggest a caterpillar-like body plan and head structures indicating herbivory consistent with known, contemporaneous insect feeding damage on seed plants. Taxonomic resolution places Srokalarva berthei as an extinct lineage, apparently possessing features closer to neuropteroid than other holometabolous lineages.
Multilocus species trees and species delimitation in a temporal context: application to the water shrews of the genus Neomys
Authors: Igea Javier , Aymerich Pere , Bannikova Anna A. , Gosálbez Joaquim , Castresana Jose 
Published: September 2015

AbstractBackgroundMultilocus data are becoming increasingly important in determining the phylogeny of closely related species and delimiting species. In species complexes where unequivocal fossil calibrations are not available, rigorous dating of the coalescence-based species trees requires accurate mutation rates of the loci under study but, generally, these rates are unknown. Here, we obtained lineage-specific mutation rates of these loci from a higher-level phylogeny with a reliable fossil record and investigated how different choices of mutation rates and species tree models affected the split time estimates. We implemented this strategy with a genus of water shrews,Neomys, whose taxonomy has been contentious over the last century.ResultsWe sequenced 13 introns and cytochromebfrom specimens of the three species currently recognized in this genus including two subspecies ofN. anomalusthat were originally described as species. A Bayesian multilocus species delimitation method and estimation of gene flow supported that these subspecies are distinct evolutionary lineages that should be treated as distinct species:N. anomalus(sensu stricto), limited to part of the Iberian Peninsula, andN. milleri, with a larger Eurasian range. We then estimated mutation rates from a Bayesian relaxed clock analysis of the mammalian orthologues with several fossil calibrations. Next, using the estimatedNeomys-specific rates for each locus in an isolation-with-migration model, the split time for these sister taxa was dated at 0.40 Myr ago (with a 95 % confidence interval of 0.26 – 0.86 Myr), likely coinciding with one of the major glaciations of the Middle Pleistocene. We also showed that the extrapolation of non-specific rates or the use of simpler models would lead to very different split time estimates.ConclusionsWe showed that the estimation of rigorous lineage-specific mutation rates for each locus allows the inference of robust split times in a species tree framework. These times, in turn, afford a better understanding of the timeframe required to achieve isolation and, eventually, speciation in sister lineages. The application of species delimitation methods and an accurate dating strategy to the genusNeomyshelped to clarify its controversial taxonomy.
Mesenchymal stem cells stabilize the blood–brain barrier through regulation of astrocytes
Authors: Park Hyun Jung , Shin Jin Young , Kim Ha Na , Oh Se Hee , Song Sook K. , Lee Phil Hyu 
Published: September 2015

Abstract
Introduction
The blood–brain barrier (BBB) protects the brain against potentially neurotoxic molecules in the circulation, and loss of its integrity may contribute to disease progression in neurodegenerative conditions. Recently, the active role of reactive astrocytes in BBB disruption has become evident in the inflamed brain. In the present study, we investigated whether mesenchymal stem cell (MSC) treatment might modulate reactive astrocytes and thus stabilize BBB integrity through vascular endothelial growth factor A (VEGF-A) signaling in inflammatory conditions.

Methods
For the inflamed brain, we injected LPS using a stereotaxic apparatus and MSCs were injected into the tail vein. At 6 hours and 7 days after LPS injection, we analyzed modulatory effects of MSCs on the change of BBB permeability through VEGF-A signaling using immunochemistry and western blot. To determine the effects of MSCs on VEGF-A-related signaling in cellular system, we had used endothelial cells treated with VEGF-A and co-cultured astrocyte and BV 2 cells treated with lipopolysaccharide (LPS) and then these cells were co-cultured with MSCs.

Results
In LPS-treated rats, MSCs restored Evans blue infiltration and the number of endothelial-barrier antigen (EBA) and P-glycoprotein (p-gp)-expressing cells, which were significantly altered in LPS-treated animals. Additionally, MSC administration following LPS treatment markedly increased the density of astrocytic filaments around vessels and reversed LPS-induced elevations in VEGF-A levels as well as endothelial nitric oxide synthase (eNOS)-dependent downregulation of tight junction proteins in the endothelium. Consequently, MSC treatment reduced neutrophil infiltration and enhanced survival of midbrain dopaminergic neurons in LPS-treated animals. In cellular system, MSC treatment led to a significant reversion of VEGF-A-induced eNOS and tight junction protein expression in endothelial cells, which led to increased EBA expressing cells. Additionally, MSC treatment significantly attenuated LPS-induced increased expressions of IL-1β in microglia and VEGF-A in astrocytes with an increase in IL-10 levels.

Conclusion
The present study indicated that MSCs may stabilize BBB permeability by modulating astrocytic endfeet and VEGF-A signaling, which may be relevant to the treatment of Parkinsonian diseases as a candidate for disease modifying therapeutics.
Some fixed point theorems in Menger probabilistic metric-like spaces
Authors: Roldán López de Hierro Antonio Francisco , de la Sen Manuel 
Published: September 2015

AbstractIn this manuscript we extend very recent fixed point theorems in the setting of Menger spaces in three senses: on the one hand, we introduce the notion of Menger probabilistic metric-like space by avoiding a non-necessary constraint (at least, for our purposes) in the properties that define a Menger space; on the other hand, we consider a more general class of auxiliary functions in the contractivity condition; finally, we show that the function $t\rightarrow1/t-1$
t
→
1
/
t
−
1
(which appears in many fixed point theorems in the fuzzy context) can be replaced by more appropriate and general functions. We illustrate our main statements with an example in which previous results cannot be applied.