bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Thermodynamic Studies of CaLaFe11O19(s).
Authors: Rakshit S. K. , Parida S. C. , Lilova Kristina , Navrotsky Alexandra 
Published: June 2013

AbstractThe title compound is thermodynamically characterized by Knudsen effusion mass spectrometry, calorimetry, and high temperature oxide melt solution calorimetry.
ChemInform Abstract: A Low‐Temperature Synthesis Route for CaAlSiN3 Doped with Eu2+.
Authors: Kubus Mariusz , Meyer H.‐Juergen 
Published: June 2013

AbstractThe strongly red‐emitting title phosphor is synthesized from CaSiF6, AlF3, Li3N, and EuCl2 using a mixture of LiCl and KCN as a flux (copper tube, 750 °C, 2 d).
ChemInform Abstract: Multifunctional “Click” Prolinamides: A New Platform for Asymmetric Aldol Reactions in the Presence of Water with Catalyst Recycling.
Authors: Paladhi Sushovan , Das Joydeb , Mishra Pratyush Kumar , Dash Jyotirmayee 
Published: June 2013

AbstractThe novel prolinamide catalyst shows excellent isolated yields, enantioselectivities, and diastereoselectivities for the title reaction.
ChemInform Abstract: Reactivity of Stabilized Vinyl Diazo Derivatives Toward Unsaturated Hydrocarbons: Regioselective Gold‐Catalyzed Carbon—Carbon Bond Formation.
Authors: Barluenga Jose , Lonzi Giacomo , Tomas Miguel , Lopez Luis A. 
Published: June 2013

AbstractNew reaction modes are involved in the gold‐catalyzed reaction of vinyldiazoacetates with the unsaturated substrates and activated arenes.
ChemInform Abstract: Gold‐Catalyzed Sequential Activation of Propargylic Carboxylates: A Facile Route to Benzoannulenes.
Authors: Oh Chang Ho , Kim Ji Hee , Oh Bu Keun , Park Jong Ryul , Lee Ji Ho 
Published: June 2013

AbstractA novel gold‐catalyzed cascade reaction of various propargylic acetates provides a highly efficient access to 6‐methylene‐6H‐benzo[7]annulene‐5,8‐diyl diacetates.
ChemInform Abstract: Pd‐Catalyzed Allylic Alkylation of CF3‐Containing Esters with Three Electron‐Withdrawing Groups.
Authors: Li Lun , Huang Donghui , Chen Qing‐Yun , Guo Yong 
Published: June 2013

AbstractA novel protocol is developed and applied to esters (I) and (VI).
ChemInform Abstract: New Approach to Synthesize β,β‐Difluorohomoallylic Alcohols (III).
Authors: Omote Masaaki , Miake Tatsuya , Tarui Atsushi , Sato Kazuyuki , Kumadaki Itsumaro , Ando Akira 
Published: June 2013

AbstractEthyl (E)‐4,4‐difluoro‐5‐hydroxy‐5‐arylpent‐2‐enoates (III) are conveniently obtained as versatile intermediates for constructing stable isosteres of peptides or fluorinated sugar molecules.
ChemInform Abstract: Photo‐ and Thermochromic Spirans. Part 38. New (1‐Alkyl‐4,5‐diphenyl)imidazolyl‐substituted Spirobenzopyrans.
Authors: Solov'eva E. V. , Chernyshev A. V. , Voloshin N. A. , Metelitsa A. V. , Minkin V. I. 
Published: June 2013

AbstractSpirocompounds of type (VIII) are prepared.
ChemInform Abstract: One‐Step Synthesis of β‐Lactams Using Cyanuric Fluoride.
Authors: Zarei Maaroof 
Published: June 2013

AbstractCyanuric fluoride is found to be a highly efficient acid activator for the direct [2 + 2] ketene—imine cycloaddition of substituted acetic acids and imines furnishing β‐lactams in high yields.
ChemInform Abstract: Copper(I) Halide Promoted Diastereoselective Synthesis of Chiral Propargylamines and Chiral Allenes Using 2‐Dialkylaminomethylpyrrolidine, Aldehydes, and 1‐Alkynes.
Authors: Gurubrahamam Ramani , Periasamy Mariappan 
Published: June 2013

AbstractSynthesis of disubstituted chiral allenes is achieved in two steps via chiral propargylamine derivatives, generated in a CuBr‐promoted reaction of 2‐dialkylaminomethylpyrrolidine with terminal alkynes and aldehydes, followed by the CuI‐promoted reaction.
ChemInform Abstract: Combining Zn Ion Catalysis with Homogeneous Gold Catalysis: An Efficient Annulation Approach to N‐Protected Indoles.
Authors: Wang Yanzhao , Liu Lianzhu , Zhang Liming 
Published: June 2013

AbstractN‐protected indoles such as (III), (V)/(VI), (VIII), and (X)/(XI) are prepared via annulation of N‐arylhydroxamic acids (I) and (IV) and alkynes.
ChemInform Abstract: Metal‐Catalyzed Rearrangements of 3‐Allenyl 3‐Hydroxyindolin‐2‐ones in the Presence of Halogenated Reagents.
Authors: Alcaide Benito , Almendros Pedro , Luna Amparo , Prieto Natividad 
Published: June 2013

AbstractThe reactions of 3‐allenyl 3‐hydroxyindolin‐2‐ones (I) with a variety of halogenating reagents in the presence of catalytic amounts of precious metals are explored.
ChemInform Abstract: Palladium‐Catalyzed C—H Activation/Cross‐Coupling of Pyridine N‐Oxides with Nonactivated Secondary Alkyl Bromides.
Authors: Xiao Bin , Liu Zhao‐Jing , Liu Lei , Fu Yao 
Published: June 2013

AbstractAn unexpected C—H activation/cross‐coupling reaction of pyridine N‐oxides with non‐activated alkyl bromides is found.
ChemInform Abstract: Oxidation of 3,4‐Dihydropyrimidin‐2(1H)‐thione Using (Diacetoxyiodo)benzene: Unprecedented Formation of Substituted 2‐(1,4‐Dihydropyrimidin‐2‐ylthio)pyrimidine.
Authors: Bhong Bhagyashree Y. , Thorat Prerana B. , Karade Nandkishor N. 
Published: June 2013

AbstractTreatment of thiones (I) with hypervalent iodine results in an unprecedented oxidation—desulfurization process to give dimers (II).
ChemInform Abstract: Synthetic Studies of Quinolizidine 195C and Derivatives.
Authors: Chou Shang‐Shing P. , Zhang Jun‐Wei , Chen Kuan‐Hua 
Published: June 2013

AbstractQuinolizidine derivatives, including two epimers of quinolizidine 195C, (XI) and (XII), are prepared using ring‐closing metathesis and cross‐metathesis as the key steps.
ChemInform Abstract: A Novel Approach for the Synthesis of 5‐Pyridylindolizine Derivatives via 2‐(2‐Pyridyl)pyridinium Ylides.
Authors: Georgescu Emilian , Dumitrascu Florea , Georgescu Florentina , Draghici Constantin , Barbu Loredana 
Published: June 2013

AbstractNew 5‐pyridylindolizine derivatives (IV) (16 examples) are synthesized via a one‐pot three‐component reaction using 1,2‐butylene oxide as reaction medium and acid scavenger.
ChemInform Abstract: Synthesis of 2‐Aminomethyl‐4‐phenyl‐1‐azabicyclo[2.2.1]heptanes via LiAlH4‐Induced Reductive Cyclization of 2‐(4‐Chloro‐2‐cyano‐2‐phenylbutyl)aziridines and Evaluation of Their Antimalarial Activity.
Authors: D'hooghe Matthias , Vervisch Karel , Toernroos Karl W. , Verhaeghe Tom , Desmet Tom , Lategan Carmen , Smith Peter J. , Chibale Kelly , De Kimpe Norbert 
Published: June 2013

AbstractThe exo‐compounds (IV) show good in vitro antimalarial activities.
ChemInform Abstract: Study of Aza‐Cyclization of α,β‐Unsaturated Carbonyl Moieties and Synthetic Application to Hexahydroapoerysopine.
Authors: Kim Hee Dong , Kim Guncheol 
Published: June 2013

AbstractBoronic acid (I) is coupled with brominated lactones under conditions A) to produce the cyclization precursors (III) or (V) which undergo intramolecular Michael addition to form azepine systems.
ChemInform Abstract: Direct Room‐Temperature Lactonization of Alcohols and Ethers onto Amides: An “Amide Strategy” for Synthesis.
Authors: Valerio Viviana , Petkova Desislava , Madelaine Claire , Maulide Nuno 
Published: June 2013

AbstractThe new methodology allows the formation of various lactones from a protected alcohol and an “amide‐masked” carboxylic acid.
ChemInform Abstract: Officinatrione: An Unusual (17S)‐17,18‐seco‐Lupane Skeleton, and Four Novel Lupane‐Type Triterpenoids from the Roots of Taraxacum officinale.
Authors: Saeki Daisuke , Yamada Takeshi , In Yasuko , Kajimoto Tetsuya , Tanaka Reiko , Iizuka Yota , Nakane Takahisa , Takano Akihito , Masuda Kazuo 
Published: June 2013

AbstractFive new lupane‐type triterpenoids, (I)‐(IV), are isolated from the root of dandelion T.
ChemInform Abstract: Nitrosyl Tetrafluoroborate Catalyzed Preparation of 2,3‐Unsaturated Glycosides and 2‐Deoxyglycosides of Hindered Alcohols, Thiols, and Sulfonamides.
Authors: Santra Abhishek , Guchhait Goutam , Misra Anup Kumar 
Published: June 2013

AbstractD‐Glucal derivative (I) reacts with alcohols, thiols, and sulfonamides under conditions A) to provide 2,3‐unsaturated glycosides with high α‐selectivity.
ChemInform Abstract: A New Cytotoxic Quinolone Alkaloid and a Pentacyclic Steroidal Glycoside from the Stem Bark of Crataeva nurvala: Study of Antiproliferative and Apoptosis Inducing Property.
Authors: Sinha Sadhna , Mishra Priyanka , Amin Hina , Rah Bilal , Nayak Debasis , Goswami Anindya , Kumar Naresh , Vishwakarma Ram , Ghosal Sabari 
Published: June 2013

AbstractNew quinolone alkaloid, crataemine (I), and new pentacyclic steroidal glycoside, crataenoside (II), show cytotoxic activities against HeLa, PC‐3 and MCF‐7 cell lines.
A randomized clinical trial comparing prophylactic upper versus whole‐neck irradiation in the treatment of patients with node‐negative nasopharyngeal carcinoma
Authors: Li Jin‐Gao , Yuan Xia , Zhang Ling‐Ling , Tang Yi‐Qiang , Liu Lan , Chen Xiao‐Dan , Gong Xiao‐Chang , Wan Gui‐Fen , Liao Yu‐Lu , Ye Jian‐Ming , Ao Fan 
Published: June 2013

BACKGROUNDThis study sought to compare the clinical outcomes of upper versus whole‐neck prophylactic irradiation in the treatment of patients with node‐negative nasopharyngeal carcinoma (NPC).METHODSBetween November 2005 and June 2012, 301 patients with node‐negative NPC were randomly assigned to receive primary plus prophylactic upper neck irradiation (UNI, 153 patients) or primary plus whole‐neck irradiation (WNI, 148 patients). Patients in both groups received irradiation to the primary tumor and the upper neck nodal regions, and patients in the WNI group also received irradiation to the lower neck. The main endpoint of the study was to compare the lower neck control rate between the 2 groups.RESULTSWith a median follow‐up period of 39 months (range, 6‐84 months), no patient in either group had a cervical node relapse. The overall survival at 3 years was 89.5% (95% confidence interval [CI] = 84.1%‐95.0%) in the UNI group and 87.4% (95% CI = 81.4%‐93.5%) in the WNI group (hazard ratio [HR] = 0.866, 95% CI = 0.41‐1.82; P = .70). The 3‐year relapse‐free survival rate was 89.8% and 89.3% (95% CI = 84.2%‐95.3% and 83.7%‐94.8%, HR = 0.914, 95% CI = 0.42‐2.00; P = .82), and the 3‐year metastasis‐free survival rate was 91.7% and 90.9% (95% CI = 87.0%‐96.5% and 85.7%‐96.1%) for the UNI and WNI groups, respectively (HR = 1.007, 95% CI = 0.44‐2.32; P = .99).CONCLUSIONSProphylactic upper neck irradiation is sufficient for patients with node‐negative NPC. Cancer 2013;119:3170–3176. © 2013 American Cancer Society.
Finding reverse nearest neighbors by region
Authors: Adhinugraha Kiki Maulana , Taniar David , Indrawan Maria 
Published: June 2013

SUMMARYCommon reverse nearest neighbor queries in spatial database run in an inefficient way because they need to check a query result with almost every nearest neighbor. This wastes many time and resources, making this approach unsuitable for mobile computation. Instead of using the neighbors as candidates for the query result, a region approach can be used to answer the query. By using this approach, any objects located in the region will be considered candidate results for the query. To reduce the cost of creating the region, we introduce the concept of a contact zone, a method that can identify the right region generator points without having to process the whole points in the space, hence make reverse nearest neighbor queries by region possible to be run in mobile devices. Copyright © 2013 John Wiley & Sons, Ltd.
[Be(ND3)4]Cl2: Synthesis, Characterisation and Space‐Group Determination Guided by Solid‐State Quantum Chemical Calculations
Authors: Kraus Florian , Baer Sebastian A. , Hoelzel Markus , Karttunen Antti J. 
Published: June 2013

AbstractTreatment of BeCl2 with dry liquid ND3 and subsequent removal of the solvent leads to the colourless microcrystalline powder of [Be(ND3)4]Cl2. It crystallises in the orthorhombic space group Pna21 with a = 9.395(4), b = 11.901(6), c = 6.761(3) Å, V = 755.9(6) and Z = 4 at 27 °C, and a = 9.3736(8), b = 11.8162(12), c = 6.6596(6) Å, V = 737.62(12) and Z = 4 at –269.6 °C. The structure contains the tetrahedral tetraammineberyllium(II) cation which follows the octet rule. It was shown to be stable under ambient conditions and temperatures up to approximately 175 °C. We additionally discuss the aid of solid‐state quantum chemical calculations for the assignment of proper crystallographic space groups in cases where the choice between centrosymmetry and noncentrosymmetry is not completely obvious, e.g. here between Pna21 and Pnma. Thermogravimetric measurements show that [Be(ND3)4]Cl2 decomposes only above approximately 175 °C, giving off two equivalents of ND3 to form [Be(ND3)2Cl2]. The latter seems to be stable up to approximately 300 °C after which it sublimes. These results show unambiguous evidence for the stability of the tetraammineberyllium(II) cations of the title compounds from –269.6 °C to 175 °C.
Effect of CO2 inhibition on biogenic isoprene emission: Implications for air quality under 2000 to 2050 changes in climate, vegetation, and land use
Authors: Tai Amos P. K. , Mickley Loretta J. , Heald Colette L. , Wu Shiliang 
Published: June 2013

AbstractThe inhibition of biogenic isoprene emission by elevated CO2 as observed in many plant taxa may significantly alter the sensitivity of air quality to global changes. We use a one‐way coupled modeling framework to perform simulations under various combinations of 2000 to 2050 changes in climate, natural vegetation, anthropogenic emissions and land use to examine the effect of the CO2‐isoprene interaction on atmospheric composition. We find that consideration of CO2 inhibition substantially reduces the sensitivity of surface ozone and secondary organic aerosol (SOA) to climate and natural vegetation, resulting in much smaller ozone and SOA increases in major populated regions than are projected by previous studies. The impact of land use on air quality is relatively insensitive to CO2 inhibition, rendering land use change the key factor that can offset or enhance the effects of anthropogenic emissions and shape air quality and climate‐relevant species in the mid‐21st century.
CAN WE MAKE SMART CHOICES BETWEEN OLS AND CONTAMINATED IV METHODS?
Authors: Basu Anirban , Chan Kwun Chuen Gary 
Published: June 2013

ABSTRACTIn the outcomes research and comparative effectiveness research literature, there are strong cautionary tales on the use of instrumental variables (IVs) that may influence the newly initiated to shun this premier tool for casual inference without properly weighing their advantages. It has been recommended that IV methods should be avoided if the instrument is not econometrically perfect. The fact that IVs can produce better results than naïve regression, even in nonideal circumstances, remains underappreciated. In this paper, we propose a diagnostic criterion and related software that can be used by an applied researcher to determine the plausible superiority of IV over an ordinary least squares (OLS) estimator, which does not address the endogeneity of a covariate in question. Given a reasonable lower bound for the bias arising out of an OLS estimator, the researcher can use our proposed diagnostic tool to confirm whether the IV at hand can produce a better estimate (i.e., with lower mean square error) of the true effect parameter than the OLS, without knowing the true level of contamination in the IV. Copyright © 2013 John Wiley & Sons, Ltd.
Full genomic characterization of a group C rotavirus isolated from a child in south Korea
Authors: Baek In Hyuk , Than Van Thai , Kim Hakyoung , Lim Inseok , Kim Wonyong 
Published: June 2013

AbstractDuring an epidemiological survey of human rotavirus infection in Seoul, Korea, from 2010 to 2011, one isolate of group C rotavirus (GCRV), named CAU10‐312, was detected in a 5‐year‐old child admitted to the hospital with acute gastroenteritis, and its complete genomic sequence was determined. The 11 gene segments of the strain possessed G4‐P[2]‐I2‐R2‐C2‐M2‐A2‐N2‐T2‐E2‐H2 genotypes. The genotype of strain CAU10‐312 appears to be closely related to strains from Bangladesh (DhakaC13 and BS347), India (v508), and England (Bristol), but distinct from Far East Asian strains, Chinese (Wu82 and YNR001) and Japanese (OH567 and BK0830). These findings may clarify the relationship of the genetics, evolutionary biology, and epidemiology of GCRVs and suggest that two very distinct genotype strains are in circulation in the world.J. Med. Virol. 85:1478–1484, 2013. © 2013 Wiley Periodicals, Inc.
Detection of erythrovirus B19 in thyroidectomy specimens from graves' disease patients: A case–control study
Authors: Page Cyril , Hoffmann Thomas Walter , Benzerdjeb Nassim , Duverlie Gilles , Sevestre Henri , Desailloud Rachel 
Published: June 2013

ABSTRACTEnvironmental factors, such as viruses, are thought to contribute to the development of thyroid autoimmunity. Erythrovirus B19 (EVB19) is suspected to be involved in Hashimoto's thyroiditis, but no direct evidence is available concerning the role of EVB19 infection in Graves' disease. The objective of this study was to investigate whether the presence of EVB19 is more frequent in thyroidectomy specimens of patients undergoing thyroidectomy for Graves' disease (cases) than for multinodular thyroid (controls). Serum and thyroidectomy specimens were prospectively collected from 64 patients referred for total thyroidectomy over a 5‐year period (2007–2011) and were investigated retrospectively and blindly for circulating EVB19 DNA by q‐PCR (Qiagen), and for EVB19 thyrocyte infection by immunochemistry (VP2‐Antibody, Dako). EVB19 serology was also determined. General clinical and laboratory data were collected. Twenty patients were referred for Graves' disease and 44 patients were referred for non‐autoimmune multinodular thyroid. Patients with thyroid cancer were excluded. Ten percent of Graves' disease patients and 27.7% of control patients had positive staining of thyrocytes for EVB19 antibodies (ns). EVB19‐positive and EVB19‐negative cases did not differ. EVB19‐positive controls were older than EVB19‐negative controls (mean age: 57.5 [35–74] vs. 45 [28–80] years, P = 0.03) No case of acute EVB19 infection was identified. EVB19‐positive serology was more frequent in controls than in Graves' disease patients (88% vs. 45%, P < 0.0001). EVB19 was detected in thyrocytes, but not more frequently in Graves' disease patients than in controls. Further studies are needed to determine the role of EVB19 infection in thyroid diseases. J. Med. Virol. 85:1414–1419, 2013. © 2013 Wiley Periodicals, Inc.
Juvenile respiratory papillomatosis: Risk factors for severity
Authors: Rodier Caroline , Lapointe Annie , Coutlée François , Mayrand Marie‐Hélène , Dal Soglio Dorothée , Roger Michel , Trottier Helen 
Published: June 2013

AbstractJuvenile recurrent respiratory papillomatosis is caused mainly by human papillomavirus genotypes 6 or 11, acquired at birth or during pregnancy from an infected mother. Recurrent respiratory papillomatosis is characterized by recurring warts growing most commonly in the larynx. Multiple surgical procedures and the risk of airway obstruction contribute to the devastating impact of this disease. Some children will go into remission after a few surgeries whereas others will require repeated interventions over several years. Further understanding of the risk factors associated with severity may contribute to tailored treatments. A retrospective study of cases diagnosed between January 1995 and December 2008 was conducted to study determinants of severe forms of juvenile recurrent respiratory papillomatosis. Demographic and clinical variables were abstracted from children's medical charts and mothers' delivery charts. Viral factors (HPV genotyping and viral load) were studied from archived biopsies. Specific HLA class II alleles and killer‐cell immunoglobulin‐like receptors genes were tested from saliva samples. Logistic regression was performed to identify risk factors for severity. Overall, 31 pediatric cases of recurrent respiratory papillomatosis were identified. The only significant factor associated with severe forms of recurrent respiratory papillomatosis was the maternal history of condylomas during pregnancy (OR: 12.05 [P = 0.05]). The analysis failed to identify risk factors that could be used clinically to identify recurrent respiratory papillomatosis cases likely to take a severe course. Although too early to determine, vaccination against the HPV types involved most commonly in recurrent respiratory papillomatosis may provide the best hope to prevent severe forms of this disease. J. Med. Virol. 85:1447–1458, 2013. © 2013 Wiley Periodicals, Inc.
Use of the HPV MLPA assay in cervical cytology for the prediction of high grade lesions
Authors: Litjens Rogier J.N.T.M. , Theelen Wendy , van de Pas Yvonne , Ossel Jessica , Reijans Martin , Simons Guus , Speel Ernst‐Jan M. , Slangen Brigitte F.M. , Ramaekers Frans C.S. , Kruitwagen Roy F.P.M. , Hopman Anton H.N. 
Published: June 2013

ABSTRACTCurrent screening methods for uterine cervical cancer such as Papanicolaou smears and/or high risk human Papillomavirus (HR‐HPV) detection have a high negative predictive value but a low positive predictive value for the presence of high grade cervical lesions. Therefore, new parameters are needed to reduce the rate of unnecessary referrals for colposcopy. The predictive value of the HPV multiplex ligation‐dependent probe amplification (MLPA) assay, which can assess simultaneously HPV16/18 viral load and viral integration, was evaluated. The assay was applied to 170 cervical cytological samples, and the results were correlated with the matching histological follow‐up. The GP5+/6+ assay and qPCR were used as a control for HR‐HPV typing. The MLPA assay classified a higher percentage of cases as high‐risk (high‐viral load and/or viral integration) with higher grades of dysplasia. There was a high correlation between the HPV MLPA assay and qPCR for viral load and HPV genotyping, and between the MLPA assay and the GP5+/6+ assay for HPV genotyping. The sensitivity and specificity of the HPV MLPA assay for the detection of high‐grade lesions were 44% and 93%, respectively. This study demonstrates that the HPV MLPA assay can reliably detect HPV 16/18, viral load, and viral integration in cytological samples. Also, high‐risk classification correlated well with the presence of high‐grade dysplasia. However, for the implementation of the MLPA assay into clinical practice, additional HR‐HPV types need to be included to increase the sensitivity of the assay, and thereby increase its negative predictive value. J. Med. Virol. 85:1386–1393, 2013. © 2013 Wiley Periodicals, Inc.