bluuebunny/crossref_metadata_2025_split huggingface dataset:
Midlife Women’s Menopausal Transition Symptom Experience and Access to Medical and Integrative Health Care: Informing the Development of MENOGAP
Authors: Taylor-Swanson Lisa , Stoddard Kari , Fritz Julie , Anderson Belinda (Beau) , Cortez Melissa , Conboy Lisa , Sheng Xiaoming , Flake Naomi , Sanchez-Birkhead Ana , Stark Louisa A. , Farah Luul , Farah Sara , Lee Doriena , Merkley Heather , Pacheco Lori , Tavake-Pasi Fahina , Sanders Wendy , Villalta Jeannette , Moreno Camille , Gardiner Paula 
Published: July 2024

Background Individuals with a uterus experience menopause, the cessation of menses, on average at age 51 years in the United States. While menopause is a natural occurrence for most, over 85% of women experience multiple interfering symptoms. Menopausal women face health disparities, including a lack of access to high-quality healthcare and greater disparities are experienced by women who are black, indigenous, and people of color. Some women are turning away from hormone therapy, and some seek integrative health interventions. Objective Some menopausal women who seek healthcare do not receive it as they lack access to medical and integrative healthcare providers. A potential solution to this problem is a medical group visit (MGV), during which a provider sees multiple patients at once. The aims of this study were to gather women’s opinions about the menopause, provider access, and conventional and integrative health interventions for later use to develop a menopause MGV. Methods We conducted a Community Engagement Session and a Return of Results (RoR) with midlife women to learn about their menopause experiences, barriers and facilitators to accessing health providers, and their interest in and suggestions for designing a future integrative MGV (IMGV). Thematic qualitative research methods were used to summarize session results. Results Nine women participated in the Session and six attended the RoR. Participants were well-educated and diverse in race and ethnicity. Themes included: an interest in this topic; unfamiliar medical terms; relevant social factors; desired whole person care; interest in integrative health; barriers and facilitators to accessing healthcare. The group expressed interest in ongoing participation in the future process of adapting an IMGV, naming it MENOGAP. Conclusion These findings highlight the importance of stakeholder engagement before designing and implementing MENOGAP and the great need among midlife women for education about the menopausal transition, integrative self-care, and healthcare.
Intramuscular Adipose Tissue in the Lumbar Paraspinal Muscles Does Not Correlate With Low Back Pain in Medical Students
Authors: Gloyeske Brian , Bakewell Brock , Woodbury Dale , Zapata Isain , Lundgreen Mason Nena 
Published: July 2024

Objective: The objective of the study is to identify any intergroup differences or statistically significant correlations between paraspinal intramuscular adipose tissue (IntraMAT) deposition and variables such as low back pain, gender, self-reported activity level, body mass index (BMI), age, and academic class-year, as measured by sonographic intensity analysis. This study is specific to a cohort of first- and second-year medical students. Materials and Methods: The right lumbar paraspinal muscles, at the level of the fifth lumbar vertebrae, were investigated with sonography among a cohort of medical students. Image pixels, within the selected region of interest, were segregated by pixel intensity and analyzed for IntraMAT content. Participants reported on additional study variables by responding to a survey. The cohort responses were analyzed to seek correlations between those variables and IntraMAT. Results: The female participants were found to have more IntraMAT ( P < .001). Most participants reported low back pain. There were no significant correlations between IntraMAT and reported low back pain, academic class year, or BMI. Moderate exercise increased IntraMAT deposition, and each year of increasing age decreased IntraMAT ( P < .05). Second-year students experienced more self-reported low back pain than first-year students. Conclusion: A cohort of medical students who were reportedly sedentary had more low back pain than their peers. Back pain was more prevalent in second-year students, irrespective of age, suggesting that ill effects of a sedentary lifestyle may be cumulative. The validity of the sonographic pixel intensity analysis performed was supported by the highly significant increase in IntraMAT observed in female participants. The relationship between low back pain, exercise, BMI, and IntraMAT was uncertain based on available evidence and the results of this study.
Venetoclax-obinutuzumab for previously untreated chronic lymphocytic leukemia: 6-year results of the randomized phase 3 CLL14 study
Authors: Al-Sawaf Othman , Robrecht Sandra , Zhang Can , Olivieri Stefano , Chang Yi Meng , Fink Anna Maria , Tausch Eugen , Schneider Christof , Ritgen Matthias , Kreuzer Karl-Anton , Sivchev Liliya , Niemann Carsten Utoft , Schwarer Anthony , Loscertales Javier , Weinkove Robert , Strumberg Dirk , Kilfoyle Allanah , Manzoor Beenish S. , Jawaid Dureshahwar , Emechebe Nnadozie , Devine Jacob , Boyer Michelle , Runkel Eva D. , Eichhorst Barbara , Stilgenbauer Stephan , Jiang Yanwen , Hallek Michael , Fischer Kirsten 
Published: July 2024

Abstract
In the CLL14 study, patients with previously untreated chronic lymphocytic leukemia (CLL) and coexisting conditions were randomized to 12 cycles of venetoclax-obinutuzumab (Ven-Obi, n = 216) or chlorambucil-obinutuzumab (Clb-Obi, n = 216). Progression-free survival (PFS) was the primary end point. Key secondary end points included time-to-next-treatment (TTNT), rates of undetectable minimal residual disease (uMRD), overall survival (OS), and rates of adverse events. Patient reported outcomes of time until definitive deterioration (TUDD) in quality of life (QoL) were analyzed. At a median observation time of 76.4 months, PFS remained superior for Ven-Obi compared with Clb-Obi (median, 76.2 vs 36.4 months; hazard ratio [HR], 0.40; 95% confidence interval [CI], 0.31-0.52; P &lt; .0001). Likewise, TTNT was longer after Ven-Obi (6-year TTNT, 65.2% vs 37.1%; HR, 0.44; 95% CI, 0.33-0.58; P &lt; .0001). In the Ven-Obi arm, presence of del(17p), unmutated immunoglobulin heavy-chain variable region, and lymph node size of ≥5 cm were independent prognostic factors for shorter PFS. The 6-year OS rate was 78.7% in the Ven-Obi and 69.2% in the Clb-Obi arm (HR, 0.69; 95% CI, 0.48-1.01; P = .052). A significantly longer TUDD in global health status/QoL was observed in the Ven-Obi than in the Clb-Obi arm (median, 82.1 vs 65.1 months; HR, 0.70; 95% CI, 0.51-0.97). Follow-up–adjusted second primary malignancies incidence rates were 2.3 and 1.4 per 1000 patient-months in the Ven-Obi and Clb-Obi arm, respectively. The sustained long-term survival and QoL benefits support the use of 1-year fixed-duration Ven-Obi in CLL. This trial was registered at www.ClinicalTrials.gov as #NCT02242942.
Atrial arrhythmia in adults with sickle cell anemia: a missing link toward understanding and preventing strokes
Authors: d’Humières Thomas , Sadraoui Zineb , Savale Laurent , Boyer Laurent , Guillet Henri , Alassaad Lara , de Luna Gonzalo , Iles Sihem , Balfanz Paul , Habibi Anoosha , Martino Suella , Amorouayeche Ziana , Dang Thuy Linh , Pham Hung d'Alexandry d'Orengiani Anne Laure , Rideau Dominique , Train Laura , Simon Theo , Ibrahim Christine , Messonnier Laurent A. , Audureau Etienne , Derbel Haytham , Calvet David , Lellouche Nicolas , Derumeaux Geneviève , Bartolucci Pablo 
Published: July 2024

Abstract
Although patients with homozygous sickle cell anemia (SCA) carry both significant left atrial (LA) remodeling and an increased risk of stroke, the prevalence of atrial arrhythmia (AA) has never been prospectively evaluated. The aim of this study was to identify the prevalence and predictors of atrial arrhythmia in SCA. From 2018 to 2022, consecutive adult patients with SCA were included in the DREPACOEUR prospective registry and referred to the physiology department for cardiac evaluation, including a 24-hour electrocardiogram monitoring (ECG-Holter). The primary endpoint was the occurrence of AA, defined by the presence of excessive supraventricular ectopic activity (ESVEA) on ECG-Holter (ie &gt;720 premature atrial contractions [PACs] or any run ≥ 20 PACs) or any recent history of atrial fibrillation. Overall, 130 patients with SCA (mean age: 45±12 years, 48% of male) were included. AA was found in 34 (26%) patients. Age (52±9 vs. 42±12 years, P=0,002), LA dilation (LAVi, 71±24 vs. 52±14 mL/m², P&lt;0.001) and history of stroke without underlying cerebral vasculopathy (26% vs. 5%, P=0.009, OR=6.6 (95%CI 1.4-30.3]) were independently associated with AA. Age and LAVi correlated with PAC load per 24 hours on ECG-Holter. An age over 47 years or a LAVi &gt;55mL/m² could predict AA with a PPV of 33% and a NPV of 92%. AAs are frequent in middle-aged patients with SCA and increase with age and LA remodeling, leading to a major additional risk factor for ischemic stroke. This study provides arguments and means to early screen for AA and potentially prevent cerebral complications.
Research on the Encapsulation Device for Lunar Samples
Authors: Du Yonggang , Wang Chunyong , Li Haoling , Zhou Ying , Ji Ming , Wang Xuesong 
Published: July 2024

AbstractThe encapsulation of lunar samples is a core research area in the third phase of the Chinese Lunar Exploration Program. The seal assembly, opening and closing mechanism (OCM), and locking mechanism are the core components of the encapsulation device of the lunar samples, and the requirements of a tight seal, lightweight, and low power make the design of these core components difficult. In this study, a combined sealing assembly, OCM, and locking mechanism were investigated for the device. The sealing architecture consists of rubber and an Ag-In alloy, and a theory was built to analyze the seal. Experiments of the electroplate Au coating on the knife-edge revealed that the hermetic seal can be significantly improved. The driving principle for coaxial double-helical pairs was investigated and used to design the OCM. Moreover, a locking mechanism was created using an electric initiating explosive device with orifice damping. By optimizing the design, the output parameters were adjusted to meet the requirements of the lunar explorer. The experimental results showed that the helium leak rate of the test pieces were not more than 5 × 10−11 Pa·m3·s−1, the minimum power of the OCM was 0.3 W, and the total weight of the principle prototype was 2.9 kg. The explosive driven locking mechanism has low impact. This investigation solved the difficulties in achieving tight seal, light weight, and low power for the lunar explorer, and the results can also be used to explore other extraterrestrial objects in the future.
Effects of antibiotic cocktail on the fecal microbiota and their potential correlation of local immune response
Authors: Liu Ting , Wang Yin , Hou Zhuoer , Shi Zhenyu , Wang Rongyun , Shi Yanan , Hua Lijiangshan , Wu Lingyun , Xu Min , Ding Xinghong , Sun Qiuhua 
Published: July 2024

Abstract
Background
The guts of mammals are home to trillions of microbes, forming a complex and dynamic ecosystem. Gut microbiota is an important biological barrier for maintaining immune homeostasis. Recently, the use of antibiotics to clear gut microbiota has gained popularity as a low cost and easy-to-use alternative to germ-free animals. However, the effect of the duration of the antibiotic cocktail on the gut microbiome is unclear, and more importantly, the effect of dramatic changes in the gut microbiota on intestinal tissue morphology and local immune response is rarely reported.

Results
We observed a significant reduction in fecal microbiota species and abundance after 1 week of exposure to an antibiotic cocktail, gavage twice daily by intragastric administration. In terms of composition, Bacteroidetes and Firmicutes were replaced by Proteobacteria. Extending antibiotic exposure to 2–3 weeks did not significantly improve the overall efficiency of microbiotal consumption. No significant histomorphological changes were observed in the first 2 weeks of antibiotic cocktail exposure, but the expression of inflammatory mediators in intestinal tissue was increased after 3 weeks of antibiotic cocktail exposure. Mendelian randomization analysis showed that Actinobacteria had a significant causal association with the increase of IL-1β (OR = 1.65, 95% CI = 1.23 to 2.21, P = 0.007) and TNF-α (OR = 1.81, 95% CI = 1.26 to 2.61, P = 0.001).

Conclusions
Our data suggest that treatment with an antibiotic cocktail lasting 1 week is sufficient to induce a significant reduction in gut microbes. 3 weeks of antibiotic exposure can lead to the colonization of persistant microbiota and cause changes in intestinal tissue and local immune responses,
Depressive symptoms across the retirement transition in men and women: associations with emotion regulation, adjustment difficulties and work centrality
Authors: Hed Sara , Berg Anne Ingeborg , Hansson Isabelle , Kivi Marie , Waern Margda 
Published: July 2024

Abstract
Background
Retirement is a major life event and factors driving depression in the retirement transition might differ in men and women. The aim was to prospectively study depressive symptoms across the retirement transition in men and women and to test associations with emotion regulation strategies (suppression and reappraisal), adjustment difficulties, and work centrality.

Methods
The sample included 527 individuals from the population-based Health, Aging and Retirement Transitions in Sweden (HEARTS) study who were working at baseline and retired during one of the following four annual measurement waves. Participants contributed with a total of 2635 observations across five measurement waves. Depressive symptoms were measured with the Center for Epidemiologic Studies Depression Scale (CES-D); total score was modelled as a function of time to and from retirement. Changes over the retirement transition were analyzed with multilevel growth curve models. Gender differences in associations with emotion regulation, adjustment difficulties and work centrality were examined by including interaction effects with sex.

Results
We observed a general reduction of depressive symptoms in the early years of retirement in both men and women. Higher suppression was related to higher depression scores while higher cognitive reappraisal was related to lower levels of depressive symptoms. Women more often used cognitive reappraisal, and men more often suppression, but no significant gender interaction in associations with depressive symptoms could be shown. Retirement adjustment difficulties and greater importance of work for self-esteem were related to higher depression scores. Greater meaning of work, on the other hand, was related to lower levels of depressive symptoms, and this association was stronger in men.

Conclusions
There was a general reduction of depression scores in the early years of retirement in both women and men. Findings suggest that basing one’s self-esteem on workplace performance was related to higher levels of depressive symptoms after retirement, while perceiving one’s job as important and meaningful may facilitate better adjustment in terms of lower depression symptom levels, especially in men.
Long-term surveillance of SARS-CoV-2 in the school community from Campo Grande, Brazil
Authors: Alcantara Daniel Maximo Correa , dos Santos Camila Maria , Torres Jaire Marinho , Stutz Claudia , Vieira Camila Aoyama , Moreira Raissa Mariele dos Santos , Rodrigues Rudielle , Marcon Glaucia Elisete Barbosa , Ferreira Eduardo de Castro , Mendes Flavia Maria Lins , Sarti Elaine Cristina Fernandes Baez , de Oliveira Thiago Fernandes , Lemos Everton Ferreira , Andrade Ursulla Vilella , Lichs Gislene Garcia de Castro , Demarchi Luiz Henrique Ferraz , Zardin Marina Castilhos Souza Umaki , Gonçalves Crhistinne Cavalheiro Maymone , Guilhermino Jislaine de Fátima , Fernandez Zoraida del Carmen 
Published: July 2024

Abstract
Background
The COVID-19 pandemic has significantly impacted education systems worldwide, with Brazil being one of the countries with the longest school closures. Over a million children and teenagers have been affected, leading to increased hunger and nutritional deficiencies. This study aimed to implement long-term surveillance of SARS-CoV-2 infections in public and private schools in Campo Grande, Brazil, after returning to in-person classes.

Methods
The study involved testing and genomic surveillance at 23 public and private schools in Campo Grande, Mato Grosso do Sul, Brazil, from October 18, 2021 to November 21, 2022. The participants eligible for enrollment were students aged 6–17 years and staff members from school institutions. At the time of collection, participants were asked if they had symptoms in the last two weeks. Whole-genome sequencing of SARS-CoV-2 was conducted to identify circulating variants and to compare them with those detected in the municipality. The demographic data and clinical history of the participants were described, and a logistic regression model was used to understand how the RT-qPCR results could be related to different characteristics.

Results
The study included 999 participants, most of whom were women. A total of 85 tests were positive, with an overall positivity rate of 3.2%. The dynamics of case frequency were consistent with those observed in the municipality during the study period. The most common symptoms reported were cough, rhinorrhea, headache, and sore throat. Symptoms were significantly associated with SARS-CoV-2 infection. Eleven lineages were identified in school community samples, with a frequency of occurrence per period similar to that found in the sequences available for the municipality. The most prevalent lineages within the sampling period were BA.2 (59.3%) and BA.5 (29.6%).

Conclusions
Our findings demonstrate that schools can play a crucial role in epidemiological surveillance, helping trigger rapid responses to pathogens such as SARS-CoV-2. Long-term surveillance can be used to track outbreaks and assess the role of children and adults in transmission. It can also contribute to pandemic preparedness, enabling a rapid response to emergencies, such as COVID-19.
Comparative analysis of microbiome in coronal and root caries
Authors: Gondo Tadamu , Hiraishi Noriko , Takeuchi Azusa , Moyes David , Shimada Yasushi 
Published: July 2024

Abstract
Background
The global rise in the elderly population has increased the prevalence of root caries. Streptococcus mutans, Lactobacilli and Actinomyces are considered the primary pathogens of dental caries in culture-based studies. This study aimed to investigate bacterial profiles in coronal and root caries lesions and determine the association of specific bacterial genera at each site.

Methods
Dentine samples from carious lesions were collected from 22 extracted teeth using an excavator. Microbial DNA was extracted from the samples using a protocol developed for this study. 16S rRNA gene amplicon sequencing was employed for microbial analysis. PCR amplification targeted the V3-V4 region of the bacterial 16S rRNA, and the amplicon sequencing used an Illumina MiSeq system (2 × 300 bp paired-end reads). Statistical analysis was performed by the Phyloseq and DESeq2 packages in R.

Results
In coronal caries, Olsenella, Lactobacillus and Prevotella were the most prevalent genera, comprising approximately 70% of the microbiome community. In the root caries, however, although Olsenella, Prevotella and Lactobacillus remained the dominant genera, they accounted for only half of the microbiome community. This study identified significant differences in alpha diversity indices between the coronal and root caries. LEfSE analysis revealed several unique genera in each caries lesion.

Conclusion
The microbiome of root caries lesions was richer and more complex than the coronal caries microbiota. The results suggest that lesion-related variations in the oral microflora may be detected in carious dentine.
Does neoadjuvant chemotherapy reduce surgical complexity in patients with advanced-stage epithelial ovarian cancer?
Authors: Aytekin Okan , Kerinc Simge Kirmizigul , Tokalioglu Abdurrahman Alp , Ucar Yesim Ozkaya , Kilic Fatih , Comert Gunsu Kimyon , Ucar Gokhan , Civelek Burak , Turan Taner 
Published: July 2024

Abstract
Background
This study aimed to determine the effect of neoadjuvant chemotherapy (NACT) on the complex surgical procedures required in addition to staging surgery for the need to achieve a residual tumor 1 cm or less in a population of stage IIIC–IV epithelial ovarian cancer patients.

Methods
Patients were referred for NACT if preoperative imaging and/or intraoperative evaluation confirmed that it was not possible to achieve a residual tumor size of 1 cm or less with cytoreductive surgery or if the patient had a poor performance status and a high American Society of Anesthesiologists (ASA) score. Surgical complexity was defined as complex or non-complex.

Results
One hundred and twenty-six patients with stage IIIC–IV ovarian cancer were included in the study. Primary cytoreductive surgery was performed in 67 patients, and interval cytoreductive surgery was performed in 59 patients after NACT. At least one complex surgery was performed in 74.6% of the patients in the primary cytoreductive surgery group and in 61% of the patients in the NACT group, with no statistically significant difference between the groups. However, the NACT group showed significantly decreased rates of low-rectal resection, diaphragmatic peritoneal stripping, and peritonectomy.

Conclusions
The analyses showed no reduction in the requirement for at least one complex surgical procedure in the group of patients who underwent NACT. Nevertheless, this group exhibited a significant decrease in low-rectal resection, diaphragmatic peritoneal stripping, and peritonectomy due to their effectiveness in reducing peritoneal disease.
The identity of clinical associates in psychology: a cross sectional, national survey
Authors: O’Driscoll Ciarán , Azmoodeh Kiana , Rana Ravinder , Hardy Gillian 
Published: July 2024

Abstract
Background
The Clinical Associate in Psychology (CAP) is a new psychological profession within the National Health Service (NHS) in the United Kingdom. This paper considers the processes developing the CAPs’ professional identity, specifically how their roles are embedded within services.

Methods
This study utilised an online survey of CAPs and all academic, clinical and managerial staff involved with CAPs. An inductive thematic analysis was undertaken.

Results
A total of 164 participants responded to the survey. Five themes were identified: Widening Access to Psychology, Workforce Development, Navigating the Unfamiliar, Trained [Master’s level] Professionals and An Emerging Ethos. In addition, key skills and unique contributions from CAPs were identified.

Conclusions
A clear professional identity is emerging, with CAPs depicted as offering versatile interventions in diverse health care settings, fostering a positive and encouraging integration of psychological expertise into the healthcare service. The study highlights areas for development to facilitate the growth and advancement of the role within the psychological workforce.