bluuebunny/crossref_metadata_2025_split huggingface dataset:
АНАЛІЗ ВИЗНАЧЕНЬ ТА НОРМАТИВНИХ ВИМОГ СИСТЕМИ ЗАХИСТУ ОБ’ЄКТА КРИТИЧНОЇ ІНФРАСТРУКТУРИ
Authors: Bubela T. Z. , Melnyk M. Y. , Nazarovets O. B. , Rudyk Y. I. 
Published: July 2024

Вступ. Зважаючи на умови постійних прогресивних змін проєктного середовища, враховуючи чинники воєнного стану та постійну невизначеність і нестабільність, стає очевидним збільшення ризику yебезпеки для життєдіяльності територій та населення. В першу чергу це відображається через масовані обстріли об’єктів критичної інфраструктури підступним ворогом. Варто зазначити, що під час російської повномасштабної агресії на сході України, за останні роки було завдано значних пошкоджень і втрат в інфраструктурі. Дані про економічні збитки підсумовуються та оновлюються і можуть повідомлятися у вигляді офіційних звітів урядових органів, міжнародних організацій, таких як Міжнародний валютний фонд або Світовий банк.
Мета. Метою є аналіз стану урегульованості профілактики та реагування щодо можливих основних загроз та потенційних негативних наслідків для об’єктів критичної інфраструктури (ОКІ), визначення їх показників для запобігання таким загрозам для критичної інфраструктури.Методи дослідження. Дослідження об'єктів критичної інфраструктури України можуть проводитися за допомогою різноманітних методів і підходів залежно від конкретної потреби та мети дослідження. Технічне обстеження, моделювання та симуляція, соціально-економічні дослідження, методи системного аналізу – все це інструменти для подальшої нашої роботи.Результати. Результати дослідження показників систем захисту в області, що стосується об'єктів критичної інфраструктури, їх технічного стану та стандартів безпеки, полягають у виявленні вразливостей та потенційних загроз, оцінці можливих ризиків і встановленні пріоритетів для захисту, оскільки в певних аспектах наші оборонні спроможності таких об’єктів є обмеженими. Ідентифіковані та опрацьовані dразливості і ризики дають змогу визначити та відповідно здійснити категоризацію та пріоритезацію найбільш критичних об'єктів, які потребують негайного вдосконалення відповідних заходів захисту. Відповідно до результатів цього аналізу розробляються конкретні рекомендації із заходів захисту та планів реагування на потенційні надзвичайні ситуації. Крім того, важливо постійно відстежувати зміни у загрозах, які в нинішніх умовах відбуваються ледь не щодня, та оновлювати заходи захисту з урахуванням змін. Ці результати дослідження є основою для розроблення стратегій захисту критичної інфраструктури та забезпечення національних інтересів. Висновки. Сформовані дані дослідження об'єктів критичної інфраструктури, включаючи паспортизацію, а також впровадження показників систем захисту на базі системи LIDAR, показали майбутню перспективу та великі можливості для розвитку та заохочення впровадження нових технологій. Існує висока ймовірність, що саме ці нововведення стануть дуже корисними та необхідними для забезпечення безпеки та ефективного функціонування інфраструктури.
An Activity-Based Costing model applied to the management process of patients with migraine at IRCCS Mondino Foundation
Authors: Degli Esposti Luca , Tabarroni Alessandro , Perrone Valentina , Gervasio Luisa , Pinelli Alberto , Sances Grazia 
Published: July 2024

Background and aim: The ageing of the general population, with the increase in chronic diseases, poses the need for using technological innovation to face the growing healthcare needs. The present analysis applied the Activity-Based Costing tool in migraine patients followed at the IRCCS Mondino of Pavia to formalize and quantify the costs of the whole patient’s management process and to estimate the overall economic burden of migraine from the perspective of the National Health Service (NHS).
Methods: A two-stage analysis was conducted. The first stage aimed at drawing patient’s pathway, defining all the possible activities and actors involved in the healthcare delivery and treatment for migraine at the IRCCS during year 2022. The second phase was the development of a model to estimate the costs of the entire process by pricing the individual activities.
Results: The described model yielded an estimated total annual cost for the overall management of migraine of € 1,222,392, corresponding to a direct cost for a therapy of approximately 6 months per single patient of € 814. The most impactive items on the estimated annual expenditures were hospitalizations, followed by diagnostic examinations after follow-up visits and drugs dispensed by Hospital Pharmacy for home-administration (monoclonal antibodies).
Conclusions: This analysis allowed detailing the single activities and resources used in migraine patient’s pathway and then estimating the direct costs sustained by the NHS. The model could be translated to other diseases for optimizing the diagnostic/therapeutic and economic management of assisted patients and improving healthcare resource allocation.
OPTIMALISASI FILING SYSTEM DOKUMEN REKAM MEDIS DI PUSKESMAS MADAPANGGA DAN BOLO TAHUN 2022
Authors: Syamsuriansyah Syamsuriansyah , Hizriansyah Hizriansyah , Adi Rizal Pratama 
Published: July 2024

Semua fasilitas pelayanan kesehatan wajib menyelenggarakan rekam medis, termasuk puskesmas. Dengan pelayanan rekam medis yang berkualitas pasien akan merasa puas, khususnya karena pasien dilayani dengan cepat, tepat dan aman oleh pihak puskesmas. Permasalahan yang sering ditemui pada bagian penyimpanan rekam medis adalah terjadinya misfile maupun duplikasi nomor rekam medis. Akibatnya, berkas rekam medis pasien lama sulit ditemukan sehingga prosespencarian berkas rekam medis pasien di rak penyimpanan membutuhkan waktu yang cukup lama. Tujuan pelaksanaan Pengabdian Kepada Masyarakat (PKM) agar sistem penyimpanan rekam medis menjadi optimal dalam rangka peningkatan kualitas pelayanan rekam medis pasien rawat jalan di Puskesmas Madapangga. Metode yang digunakan berupa sosialisasi tentang optimalisasi sistem penyimpanan rekam medis di Puskesmas Madapangga dan Bolo. Sebelum sosialisasi, dilakukan pre-test dan setelah sosialisasi dilakukan kegiatan post-test dengan tujuan mengetahui tingkat pemahaman mitra tentang materi sosialisasi. PKM ini dilakukan pada bulan agustus di Puskesmas Madapangga. Peserta dari kegiatan PKM ini adalah semua petugas rekam medis di Puskesmas Madapangga. Madapangga sebanyak 6 (enam) orang dan Bolo sebanyak orang. Hasil dari kegiatan PKM ini adalah adanya peningkatan pengetahuan mitra tentang penyimpanan rekam medis dari nilai rata-rata 45 menjadi 85 point.
SOSIALISASI PROGRAM BERSIH PANTAI DAN EDUKASI KEPADA MASYARAKAT LINGKUNGAN PANTAI LOANG BALOQ KOTA MATARAM
Authors: Junaidin Junaidin , Irawansyah Irawansyah , Sahbany Sri , Riscal Detty Agustin , Hadi Lalu Adiyatma Taopikul 
Published: July 2024

Pantai loang baloq memiliki potensi yang sangat besar untuk dikembangkan jika program-program yang ada pada pemrintah dapat ditindak lanjuti secara bersama-sama oleh pemerintah, masyarakat dan perguruan tinggi. Pantai loang balloq memiliki letak demografi dan topografi yang strategis sangat mendukung aktivitas kepariwisataan, luas area dan kelengkapan sarana sanset yang menjadi minat utama soarang wisata sebagai pilihan berkunjung di pantai loang baloq. Kesadaran masyarakat khususnya pengunjung Pantai Loang Baloq akan pentingnya menjaga kebersihan lingkungan masih sangat kurang karena masih ada masyarakat yang membuang sampah sembarangan terutama sampah plastik bekas pembungkus makanan yang dibiarkan berserakan di sekitar pantai. Pentingnya pemahaman konsep kebersihan bagi masyarakat sejak dini sehingga kebersihan lingkungan dapat dinikmati oleh semua masyarakat serta kemamfaatan umum dapat dicapai melalui sosialisasi dan aksi sosial kebersihan lingkungan. Hasil dari pengabdian masyarakat yang tim lakukan banyak sekali dampaknya. Pertama; selama berlangsungnya pengabdian, masyarakat sempat antusias berpartisipasi dalam pelaksanaan sosialisasi dan aksi social kebersihan pantai yang dilakukan oleh tim pelaksana pengabdian dari awal sampai berakhirnya acara. Pada dasarnya masyarakat menyadari akan pentingnya menjaga kebersihan pantai guna melestarikan lingkungan dan meningkatkan kualitas kesehatan. Namun dalam pelaksanaan meningkatkan pemahaman tersebut dibutuhkan motivasi lebih lanjut baik dari pemerintah maupun dari organisasi pecinta lingkungan.
Cognitive impairment and associated factors among patients with diabetes mellitus in Africa: a systematic review and meta-analysis
Authors: Chekol Tassew Worku , Ferede Yeshiwas Ayal , Zeleke Agerie Mengistie 
Published: July 2024

BackgroundInappropriate management of blood sugar in patients with diabetes mellitus leads to micro-vascular and macro-vascular complications, subsequently leading to high morbidity and mortality rates. In addition, diabetes independently increases the occurrence of cognitive impairment complicated by dementia. Scientific evidence on the magnitude of cognitive impairment will provide a sound basis for the determination of healthcare needs and the planning of effective healthcare services. Despite this, there are no comprehensive data on the prevalence and associated factors of cognitive impairment among patients with diabetes in Africa.MethodsTo identify relevant articles for this review, we searched PubMed, Cochrane Library, Science Direct, African Journals Online, and Google Scholar. After extraction, the data were imported into Stata software version 11 (Stata Corp., TX, USA) for further analysis. The random-effects model, specifically the DerSimonian and Laird (D+L) pooled estimation method, was used due to the high heterogeneity between the included articles. Begg’s and Egger’s regression tests were used to determine the evidence of publication bias. Sub-group analyses and sensitivity analyses were also conducted to handle heterogeneity.ResultsThe pooled prevalence of cognitive impairment among patients with diabetes in Africa is found to be 43.99% (95% CI: 30.15–57.83, p &lt; 0.001). According to our analysis, primary level of education [pooled odds ratio (POR) = 6.08, 95% CI: 3.57–10.36, I2 = 40.7%], poorly controlled diabetes mellitus (POR = 5.85, 95% CI: 1.64–20.92, I2 = 87.8%), age above 60 years old (POR = 3.83, 95% 95% CI: 1.36–10.79, I2 = 63.7%), and diabetes duration greater than 10 years (POR = 1.13; 95% CI: 1.07–1.19, I2 = 0.0%) were factors associated with cognitive impairment among patients with diabetes.ConclusionBased on our systematic review, individuals with diabetes mellitus exhibit a substantial prevalence rate (43.99%) of cognitive impairment. Cognitive impairment was found to be associated with factors such as primary level of education, poorly controlled diabetes mellitus, age above 60 years, and diabetes duration greater than 10 years. Developing suitable risk assessment tools is crucial to address uncontrolled hyperglycemia effectively.Systematic review registrationhttps://www.crd.york.ac.uk/prospero, identifier CRD42024561484.
Circulating miR-28-5p is overexpressed in patients with sarcopenia despite long-term remission of Cushing’s syndrome: a pilot study
Authors: Seco-Cervera Marta , Ibáñez-Cabellos José Santiago , Pallardo Federico V. , García-Giménez José-Luis , Aulinas Anna , Martel-Duguech Luciana , Webb Susan M. , Valassi Elena 
Published: July 2024

IntroductionPatients with Cushing’s syndrome (CS) in remission show sustained fatigue, myopathy, and an increased prevalence of sarcopenia. The mechanisms that determine these persistent muscle problems are not well known. We aimed to identify circulating microRNAs (miRNAs) with differential expression that could be potential biomarkers for the diagnosis and/or prognosis in CS.Patients and methodsThirty-six women in sustained remission for 13 ± 7 years (mean ± SD) from CS, with a median age (IQ range) of 51 (45.2–60) years and mean ± SD BMI of 27 ± 4 Kg/m2, and 36 matched healthy controls were investigated. In 7 patients sarcopenia was present according to the European Working Group on Sarcopenia in Older People (EWGSOP) criteria. Small RNA libraries were generated and indexed using a modified Illumina TruSeq small RNA-sequencing protocol. MiRNAs were identified in plasma using bioinformatic analysis, and validation was carried out using RT-qPCR. For the validation, Taqman probes were performed on QuantStudio 5 equipment (Applied Biosystems).ResultsIn a first discovery group using RNA-sequencing, plasma samples of 18 CS patients and 18 healthy subjects were investigated; circulating miR-28-5p, miR-495-3p and miR-654-5p were upregulated in CS patients as compared with controls (p&lt;0.05). In a validation study of the 3 upregulated miRNAs in 36 patients and 26 controls, no differences were observed by RT-qPCR; however, the expression of circulating miR-28-5p was upregulated in CS patients with sarcopenia as compared with those without (AUC for fold-change in the ROC analysis, 0.798; p=0.0156). The optimized cut-off value for miR-28-5p to identify CS patients with sarcopenia was 3.80, which yielded a sensitivity of 86% and a specificity of 69%.ConclusionMiR-28-5p, a muscle-specific microRNA involved in myotube proliferation and differentiation in vivo, may serve as an independent non-invasive biomarker for identifying CS patients at high-risk of sarcopenia despite biochemical remission.
Modeling of a “Hydrogen Valley” to investigate the impact of a regional pipeline for hydrogen supply
Authors: Rosén Sofia , Göransson Lisa , Taljegård Maria , Lehtveer Mariliis 
Published: July 2024

Introduction: The transition towards electrolysis-produced hydrogen in refineries and chemical industries is expected to have a potent impact on the local energy system of which these industries are part. In this study, three urban areas with hydrogen-intense industries are studied regarding how the energy system configuration is affected if the expected future hydrogen demand is met in each node individually, as compared to forming a “Hydrogen Valley,” in which a pipeline can be used to trade hydrogen between the nodes.Method: A technoeconomic, mixed-integer, linear optimization model is used to study the investments in and dispatch of the included technologies with an hourly time resolution, while minimizing the total system cost. Four cases are investigated based on the availability of offshore wind power and the possibility to invest in a pipeline.Results: The results show that investments in a pipeline reduces by 4%–7% the total system cost of meeting the demands for electricity, heating, and hydrogen in the cases investigated. Furthermore, investments in a pipeline result in greater utilization of local variable renewable electricity resources, as compared to the cases without the possibility to invest in a pipeline.Discussion: The different characteristics of the local energy systems of the three nodes in local availability of variable renewable electricity, grid capacity and available storage options compared to local demands of electricity, heating and hydrogen, are found to be the driving forces for forming a Hydrogen Valley.
The taxonomic composition and chronology of a museum collection of Coleoptera revealed through large-scale digitisation
Authors: Garner Beulah H. , Creedy Thomas J. , Allan Elizabeth L. , Crowther Robyn , Devenish Elizabeth , Kokkini Phaedra , Livermore Laurence , Lohonya Krisztina , Lowndes Nicola , Wing Peter , Vogler Alfried P. 
Published: July 2024

IntroductionHistoric museum collections hold a wealth of biodiversity data that are essential to our understanding of the rapidly changing natural world. Novel curatorial practices are needed to extract and digitise these data, especially for the innumerable pinned insects whose collecting information is held on small labels.MethodsWe piloted semi-automated specimen imaging and digitisation of specimen labels for a collection of ~29,000 pinned insects of ground beetles (Carabidae: Lebiinae) held at the Natural History Museum, London. Raw transcription data were curated against literature sources and non-digital collection records. The primary data were subjected to statistical analyses to infer trends in collection activities and descriptive taxonomy over the past two centuries.ResultsThis work produced research-ready digitised records for 2,546 species (40% of known species of Lebiinae). Label information was available on geography in 91% of identified specimens, and the time of collection in 39.8% of specimens and could be approximated for nearly all specimens. Label data revealed the great age of this collection (average age 91.4 years) and the peak period of specimen acquisition between 1880 and 1930, with little differences among continents. Specimen acquisition declined greatly after about 1950. Early detected species generally were present in numerous specimens but were missing records from recent decades, while more recently acquired species (after 1950) were represented mostly by singleton specimens only. The slowing collection growth was mirrored by the decreasing rate of species description, which was affected by huge time lags of several decades to formal description after the initial specimen acquisition.DiscussionHistoric label information provides a unique resource for assessing the state of biodiversity backwards to pre-industrial times. Many species held in historical collections especially from tropical super-diverse areas may not be discovered ever again, and if they do, their recognition requires access to digital resources and more complete levels of species description. A final challenge is to link the historical specimens to contemporary collections that are mostly conducted with mechanical trapping of specimens and DNA-based species recognition.
Distinct maturation, glucose metabolism, and inflammatory function of human monocytes-derived IDECs mediated by anti-IgE and Pam3CSK4 alone or in combination
Authors: Gao Cuie , Zhao Ying , Ge Lan , Liu Wenying , Zhang Mengjie , Ni Bing , Song Zhiqiang 
Published: July 2024

BackgroundCell energy metabolism controls the activation and function of dendritic cells (DCs). Inflammatory dendritic epidermal cells (IDECs) in skin lesions of atopic dermatitis (AD) express high-affinity IgE receptor (FcϵRI) and toll-like receptor 2 (TLR2), which mediate the generation and maintenance of inflammation. However, cellular energy metabolism and effector function of IDECs mediated by FcϵRI and TLR2 have not been fully elucidated.MethodsIDECs in vitro were treated with TLR2 agonist Pam3CSK4 and anti-IgE alone or in combination for 24 h. Further, we analyzed the expression of cell surface activation markers, production of inflammatory factors, and cellular energy metabolism profiles of IDECs by using flow cytometry, multiplex assay, RNA sequencing, targeted energy metabolism, and seahorse assays.ResultsCompared to the unstimulated or anti-IgE groups, Pam3CSK4 alone or combined with anti-IgE groups significantly increased the expression of CD80, CD83, and CD86 on IDECs, but did not affect the expression of the above markers in the anti-IgE group. The release of inflammatory cytokines increased in the Pam3CSK4 alone or combined with anti-IgE groups, while there was a weak increasing trend in the anti-IgE group. The glycolysis/gluconeogenesis pathway of carbon metabolism was affected in all treatment groups. Furthermore, compared to the control group, we found a decrease in pyruvic acid, upregulation of PFKM, downregulation of FBP1, and increase in extracellular lactate, glycolysis rate, and glycolysis capacity after all treatments, while there was no difference between each treatment group. However, there was no difference in glycolytic reserve and mitochondrial basic and maximum respiration among all groups.ConclusionOur results indicate that glycolysis of IDECs may be activated through FcϵRI and TLR2 to upregulate inflammatory factors, suggesting that danger signals from bacteria or allergens might evoke an inflammatory response from AD through the glycolysis pathway.
Structural, blood flow and functional changes in the macular area and the expression of aqueous humor factors in myopia
Authors: Yang Lu , Niu Honglei , Sun Wencui , Zhang Dongchang , Li Shuangnong , Hao Shaofeng , Wang Minting , Wang Chuan , Hu Junping , Li Xian 
Published: July 2024

ObjectiveTo compare the macular area parameters and aqueous humor factors between myopia and emmetropia.MethodsConvenience sampling was used to select patients who visited the Changzhi Aier Eye Hospital’s department of ophthalmology from December 2018 to December 2022 as the study participants. They were divided into three groups according to whether they were diagnosed as mild myopia myopic, highly myopic or not as follows: the mild myopia group (60 cases, 108 eyes), the high myopia group (46 cases, 78 eyes) and the healthy emmetropia group (40 cases, 65 eyes). The differences in the macular integrity (MI) assessment, optical coherence tomography and optical coherence tomography angiography parameters and aqueous humor factors were compared between the three groups.ResultsAL in high myopia group was the highest, and that in emmetropia group was the lowest. The BCVA of mild myopia group was the highest. The RS in the high myopia group were significantly lowest in the three groups (26.42 ± 1.04 vs. 28.34 ± 0.76 vs. 31.92 ± 0.77) (F = 5.374, p = 0.013). The 63% BCEA, 95% BCEA and MI in the high myopia group were significantly highest (p &lt; 0.05). The mean RPE thickness, mean CT and mean RT in the high myopia group were lowest (p &lt; 0.05). The blood flow density were lowest in the superficial fovea, paracentral fovea and different subdivisions of the paracentral fovea in the high myopia group (p &lt; 0.05). The VEGF concentration in the aqueous humor of the high myopia group was lowest (25.62 ± 17.43 vs. 32.45 ± 24.67 vs. 64.37 ± 21.14) (F = 9.237, p &lt; 0.001). The MMP-2 concentration was highest (483 ± 201.48 vs. 410 ± 142.37 vs. 386 ± 154.34) (F = 5.542, p = 0.018). The VEGF concentration in the aqueous humor factor was negatively correlated with the AL in the myopia group (r = −0.438, p = 0.002), the MMP-2 concentration was positively correlated with the AL (r = 0.484, p = 0.010).ConclusionPatients with high myopia showed decreased retinal light sensitivity, fixation stability, superficial blood flow density and retinal thickness compared with people with emmetropia. A decreased VEGF concentration and increased MMP-2 concentration in the aqueous humor factor have potential associations with the development of high myopia.