bluuebunny/crossref_metadata_2025_split huggingface dataset:
1008 – Recurrent Hyponatremia Induced By Antidepressants: Purposely a Case
Authors: Martínez Cortés M. , Ogando Portilla N. , Torio Palmero I. , Del Nido Varo L. , Ortega Bernardo M.C. , Jimenez Arriero M.A. 
Published: July 2013

IntroductionHyponatremia is an antidepressants known adverse effect, ADH secretion has been postulated in its etiology.ObjectivesTo identify risk factors for hyponatremia induced by antidepressants and psychopharmacologic alternatives.MethodsLiterature search was performed in PubMed. We report of a case of recurrent hyponatremia treated in our center: woman, 57years old, HIV, HCV; performing 4 episodes of severe hyponatremia in 5 months of treatment involving thiazide, venlafaxine, citalopram, olanzapine,haloperidol, enalapril, escitalopram.ResultsRisk of hyponatremia is higher in patients treated with antidepressants (OR = 2.97), especially serotoninergic antidepressants (OR = 3.96). Elderly and thiazide increment that risk (OR = 6.31 and OR = 8.4 respectively), specially age, thiazide and SSRIs (OR = 148). Higher prevalence in females, lower limit levels of sodium and low body weight. All SSRIs are likely to produce hyponatremia. The effect appears in the first month, it's not dose-dependent and recovers by interrupting treatment. Some cases have been reported following re-exposure to the same or different antidepressant: fluvoxamine and paroxetine (Arizon, 2002), duloxetine and escitalopram (Stovalle, 2009), sertraline and fluoxetine (Raphael, 2010), sertraline and citalopram (Pure, 2011).ConclusionEarly detection is important, as well as the evaluation of concomitant risk factors in all patients starting antidepressant. Some asymtomatic cases can be unnoticed by clinicians, so risk patients it seems necessary to control ion pretreatment periodically, and to chose safer treatments (bupropion, agomelatine, mirtazapine and reboxetine). In our case, age, sex, concomitant diseases, low sodium and low weight were determinants for the recurrence of the disorder.
1009 – Outcome Of Hospital Treatment For Opioid Dependence In Slovenia - Preliminary Results
Authors: Delic M. , Pregelj P. 
Published: July 2013

IntroductionIn the field of drug abuse treatment, noncompletion and negative outcome is a general problem.ObjectivesOutcome of hospital treatment of opioid dependence was examined.AimsThe purpose of the present study was examination of a cohort of patients treated at Centre for treatment of drug addiction at the beginning of the treatment, after three and six months.MethodsA group of 113 patients consecutively admitted to a closed detoxification unit between October 2011 and September 2012 were assessed. Positive outcome of the treatment is defined as complete abstinence in the 28 days before review. Baseline data were obtained using The Treatment Outcomes Profile (TOP), The Drug Addiction Treatment Efficacy Scale (DATES), and a semistructured research interview for obtaining information on patient's sociodemographic characteristics. Follow up scores of TOP and DATES have been recorded after three and six months.ResultsFifty-two patients completed 6 weeks of detoxification program. After 3 months 45 of 84 evaluated subjects (53%) had a positive outcome, 14 patients (12%) abused heroin and 36 patients (32%) abused other drugs. After 6 months 14 of 52 evaluated patients (27%) had a positive outcome and 9 patients (8%) used heroin.ConclusionThe share of patients with positive outcome peaked at 3 months, however the decreased use of heroin was sustained throughout the observation period.
1011 – Psychiatry In Poland: Toward Development
Authors: Samochowiec J. , Heitzman J. , Rajewski A. 
Published: July 2013

Since collapse of communism in 1989, the Polish mental health system has moved through the long deinstitutionalization process, reducing number of beds in psychiatric hospitals. The system of occupational and rehabilitation psychiatry was virtually collapsed. Some psychiatric hospitals received EU financing programs and improved their standards. The morbidity of affective disorders, increased ten times in Poland same as non-alcohol dependencies. The current economic crisis did not mobilize professionals. Because of that, the Polish Psychiatric Association engaged in introducing the looking-forward National Program of Mental Health Care, which is currently underway in Poland (planned for 2011-2015). The Program is multi-focused, mainly creating basic psychiatric system of care, dispersed throughout the whole country, for residual psychotic patients, disabled people, alcohol dependents and dementia patients. However the plan does not constitute other parts of the system, like highly-specialized and expensive centers for patients with more complex diagnostic and therapeutic needs. Meantime, the Polish total spendings for psychiatry did not raise for the second year in a row. That's one of the lowest European levels of the financing psychiatry (3,3-3,5% of whole Healthcare spend). The number of psychiatrists in Poland (2500), clinical psychologists and psychotherapeutists is still low.1.Bilikiewicz A. Psychiatry at the turn of the 20th and 21st centuries Psychiatr Pol. 1998; 32:547-552.Heitzman J. From the president of the Polish Psychiatric Association]. Psychiatr Pol. 2011;45:5-8.
1013 – Mild Cognitive Impairment - Pharmacotherapeutic Opportunities
Authors: Podea D.M. , Mila C. , Blaj M.M. 
Published: July 2013

IntroductionMild cognitive impairment (MCI) is considered today to be a prodromal stage of Alzheimer's dementia, but without standardized pharmacotherapy.ObjectivesTo follow the outcome of patients diagnosed with MCI treated with nootropics, alternative herbal agents, cholinesterase inhibitors.AimsTo assess the efficacy of early treatment in MCI.Methods200 patients (over 60 years) diagnosed with MCI were evaluated using the MMSE (Mini Mental State Examination) scale at screening, after 1 and 2 years of treatment. They were divided in four groups:A -50 patients treated with Piracetamum 1600mg/dayB -50 patients treated with Rhodiola-rosea, 2capsules/dayC -50 patients treated with Galantamine, 16mg/dayD -50 patients not treatedResultsThe improvement of the MMSE score was as following:[Results].MMSE scoreScreeningImprovement after 1 yearImprovement after 2 yearsGroup A23.962.121.88Group B24.161.972.28Group C23.962.142.88Group D24.5No improvement-2.86 (worsening)ConclusionsComparing the outcome of treated and non-treated groups, we observed that the early treatment of MCI delays the transition to dementia. The outcome of the treated groups after 1 year of treatment was approximately the same. Longtime treatment shows a better improvement in the group treated with cholinesterase inhibitors (Galantamine) compared to the other treated groups, but not statistically significant. Galantamine improves cognitive function. This study proves the necessity of early treatment for MCI to delay the transition to dementia.
1015 – Suicides In The Greek Island Of Crete During The Economic Crisis: Reality Vs Myth
Authors: Vgontzas A.N. , Kastanaki A. , Michalodimitrakis E. , Basta M. , Koutentaki E. , Michalas N. 
Published: July 2013

IntroductionRecently, suicides in Greece, have drawn national and international interest due to the current economic crisis. According to published reports, suicides in Greece have increased up to 40%. Specifically, lay press has highlighted Crete as an area with the sharpest increase of suicides in Greece.ObjectivesTo explore whether the economic crisis is associated with increased suicide rates in Crete.AimTo investigate the suicide rates in Crete between 1999-2011.MethodsData on suicides were selected from the Department of Forensic Medicine files of the University Hospital of Heraklion/Crete, as well as from the Forensic Medicine Files of Crete.ResultsOur analysis showed that during the period examined (1) Crete, although has the highest suicide rate in Greece, there is no significant increase between 1999-2011, (2)Deaths due to suicide are four times more frequent in men compared to women, (3) In women there is a significant decrease of suicides, (4) There is a decreasing trend for suicides in Western Crete whereas, there is an increasing trend in Eastern Crete.ConclusionsCrete has the highest suicide rates in Greece, which however, has not increased during the last 13 yrs. There is a relative increase of suicides in Eastern compared to Western Crete during this period. Our findings do not support the popular belief of increased suicides due to the current economic crisis. The relative increase of suicides in Eastern Crete may be explained by other factors, i.e the lack of community psychiatric services in the area.
1024 – Prospective Analysis Of Stn Dbs In Parkinson's Disease: Motor And Non-motor Symptoms Evolution Link To Electrodes Localization
Authors: de Chazeron I. , Pereira B. , Durif F. , Llorca P.-M. , Chéreau-Boudet I. 
Published: July 2013

Even if evidence suggests that Deep Brain Stimulation (DBS) of the Subthalamic Nucleus (STN) provides a beneficial clinical effect in Parkinson's disease (PD) for up to 10 years there are also several potential risks among them psychiatrics complications.The aim of this study was to identify the patient-related, medicosurgical, and psychosocial factors that influence PD patient's evolution in STN DBS.MethodWe investigate, in 36 STN DBS PD patients, depression, anxiety and mania at baseline, 3-mounth post-surgery and 6-mounth post-surgery. At baseline, demographic data and clinical characteristics (duration of disease, PD medication, past psychiatric history were also collected. Scores at motor section of the unified Parkinson disease rating scale and PD medication were evaluated at baseline, 3-mounth post-surgery and 6-mounth post-surgery. A multivariate analysis and a factorial discriminant analysis (FDA) were considered to study differences between surgical outcomes considering an adjustment on disease duration.ResultsThirty six patients with Parkinson's disease treated with STN-DBS were analyzed considering stimulating electrodes localization (‘in’, ‘frontier’, ‘out’ of STN).Concerning the pre-surgical parameters, no configuration was found.Considering only 3-mounth post-surgery parameters (electrodes localization, motor scores, psychiatric data, PD medication) patients differ according to surgical positioning: ‘frontier’/’out’ and ‘in’ but the best separation between the 3 groups of localization was obtain including pre-surgical post-surgery parameters. This segregation was maintained at 6-mounth postsurgery.ConclusionsOur work provides preliminary answer to the question of impact of the exact electrode position on neuropsychological side effects of STN-DBS and enhances the importance of combining pychiatrico-neuro-surgical data.
1029 – Relationship Between Aberrant Salience Processing And Psychotic Symptoms In a Clinical Trans-diagnostic Sample: Preliminary Data
Authors: Lelli L. , Godini L. , Spadafora M. , Pietrini F. , Lo Sauro C. , Ballerini A. 
Published: July 2013

IntroductionAberrant salience consists of the unusual or incorrect assignment of salience, significance or value to different innocuous stimuli. It has been hypothesized that subjects with an aberrant salience could be proneness to develop psychosis. Despite the importance of this concept in psychosis, only few instruments assess aberrant salience.Objectives and aimsTo evaluate aberrant salience processing in a clinical trans-diagnostic sample and its relationship with psychotic symptoms.MethodsThirty-six outpatient subjects attending the Psychiatric Unit of the University of Florence were recruited: 9 with Major Depression Disease (MDD), 8 with Schizophrenia (SC), 19 with Bipolar Disorder (BD). Patients were assessed by means of a clinical interview (SCID-I/P) and several questionnaires, including the Aberrant Salience Inventory (ASI).ResultsThe three groups showed significant differences in the lifetime presence of psychotic symptoms, with higher frequency in BD and SC patients (p< 0.01). Significant differences in ASI scores were found between MDD and BD (p< 0.01), and SC and BD (p< 0.01), while any difference between BD and SC was observed. Subjects with positive ASI (cut-off>14) reported more frequently past and lifetime psychotic symptoms (p< 0.01) and constituted a distinct cluster from patients with ASI score < 14.ConclusionAberrant salience is significantly associated to lifetime psychotic symptoms. Thus it represents a relevant psychopathologic dimension that requires a careful investigation in patients with an history of psychotic events. The ASI could represent an useful instrument to evaluate the proneness of clinical and pre-clinical samples to develop psychotic symptoms.
1030 – Ocular Pigmentation And Cataract In Therapy With Phenothiazine
Authors: Celona D. , Panarello S. , Zangrando A. , Carlino D. , De Vanna M. 
Published: July 2013

IntroductionSince 1960, a decade after the introduction of phenothiazine drugs, there were reports of drug related ocular opacities and pigmentation in patients who had been receiving continuous high dose therapy, particularly with chlorpromazine. These ocular effects seem to be related to high doses of phenothiazines and are potentially irreversible. The purpose of our study is to evaluate the pathophysiology of ocular damage, risk factors, treatment and any potential reversibility.Material and methodsBibliographic research used PubMed and PsychINFO and conduced to 12 papers.ResultsAnalysis of papers has shown that the main pathophysiological mechanism is related to an alteration of excretion of catecholamines, that exposure to sunlight presents a risk factor for the development of corneal deposits and cataract while, as regards the reversibility of these effects, the data are still controversial.ConclusionsIt is necessary, for psychiatrists, the information of the various ocular adverse effects of therapy with phenothiazine so that can be arranged to create a closer and more effective collaboration with an ophthalmologist to prevent and treat this disease.Moreover, other studies are necessary to lead to an appropriate treatment plan.
1031 – Risk Of Psychiatric Disorders In Hypospadias - a Nationwide Swedish Cohort Study
Authors: Butwicka A. , Lichtenstein P. , Landén M. , Nordenström A. , Nordenskjöld A. , Frisén L. 
Published: July 2013

IntroductionEven though 0.3-0.8% percent of the male population are born with hypospadias, it is not known if this is associated with an increased risk for psychiatric morbidity later in life.AimsThe aim of this study was to assess the association between hypospadias and risk of psychiatric disorders in affected individuals.MethodsThe association between hypospadias and psychiatric disorders was examined in a population-based cohort study using Swedish registers. Individuals born in Sweden between 1973 and 2009 were included in the study. Among them, 11,156 patients with hypospadias were identified and matched with 1,098,714 distinct controls by year of birth and county. The following outcomes were evaluated: 1- suicide attempt, 2- psychotic, 3- mood, 4-anxiety, 5- eating, 6- personality disorders, 7- disorders due to psychoactive substance use, 8- ADHD, 9- pervasive developmental disorders, 10- intellectual disabilities, and 11- other childhood emotional disorders.ResultsAfter adjusting for socio-economic and perinatal factors, malformations and/or genetic syndromes, patients with hypospadias were more likely to be diagnosed with pervasive developmental disorders (OR 1.4; 95% CI 1.1-1.6), intellectual disabilities (OR 1.8; 95% CI 1.6-2.1), ADHD (OR 1.2; 95% CI 1.0-1.4) and other childhood emotional disorders (OR 1.3; 95% CI 1.1-1.4) compared to the controls. No relation between other psychiatric diagnosis and hypospadias was found.ConclusionHypospadias is associated with an increased risk of neurodevelopmental disorders.
1034 – The Metabolic Syndrome And Late-life Depression
Authors: Marijnissen R. , Smits J. , Schoevers R. , van den Brink R. , Holewijn S. , Franke B. , de Graaf J. , Oude Voshaar R. 
Published: July 2013

ObjectivesThe association between depression and metabolic syndrome is becoming more obvious.AimsWe examined the relationship between the number and individual components of metabolic syndrome and late-life depressive symptom clusters.MethodsIn 1279 individuals aged 50 through 70 participating in the Nijmegen Biomedical Study (Cross-sectional populationbased survey), we measured all metabolic syndrome components and depressive symptoms using the Beck Depression Inventory (BDI). Principal components analysis of BDI-items yielded two factors, representing a cognitive-affective and a somatic-affective symptom-cluster. Multiple regression analyses adjusted for confounders were conducted with BDI sum score and both depression symptom-clusters as dependent variables, respectively. We explored the differences in this association between men and women.ResultsIn fully adjusted models, both presence of the metabolic syndrome as well as number of components was associated with the BDI sumscore(resp. β=0.063;p=0.022 vs. β=0.112;p< 0.001), the latter showing the strongest association. These associations were primarily driven by the somatic-affective symptom-cluster. Testing individual components of the metabolic syndrome, showed that in men waist circumference, triglycerides and HDL cholesterol were significantly associated with depression, whereas in women only the waist circumference.ConclusionsThe specific association somatic-affective symptoms suggest confounding by a (subclinical) somatic condition in stead of a real association with classical depression. The identified sex-differences suggest different pathways between depression and metabolic perturbations in men only. However, as vascular disease develops at higher ages in women and findings were in the same direction but non-significant in women, future research in older women sample should confirm our findings.
1036 – Characteristics Of Patients And Factors Associated To Discharge From Residential Facilities: a Prospective Cohort Study In Italy
Authors: de Girolamo G. , Candini V. , Buizza C. , Ferrari C. , Boero M.E. , Giobbio G.M. , Goldschmidt N. , Greppo S. , Iozzino L. , Maggi P. , Melegari A.L. , Pasqualetti P. , Rossi G. 
Published: July 2013

IntroductionPERDOVE study is a prospective observational cohort study, which providing follow-up at one year, aims to investigate the socio-demographic and clinical characteristics of patients in in the 23 medium-long term RFs of the St John of God Order.Objectives(1)To describe the sociodemographic, clinical, and treatment-related characteristics of RF-patients during an index period in 2010;(2)to identify predictors and characteristics associated with discharge at 1-year follow-up;(3)to evaluate clinicians’ predictions about each patient's likelihood of Home Discharge (HD).MethodsAll patients staying in September 2010 with a primary psychiatric diagnosis received a set of standardized assessment instruments, including a “Patient Schedule”, BPRS, HONOS, PSP, PHI, and SLOF. Detailed socio-demographic and clinical data were also collected. Logistic regression analyses were run to identify independent discharge predictors.ResultsThe study involved 403 patients. 66,7% is male, mean age is 49 (±10). 70.7% is unmarried. The average duration of illness of these patients is 23 years. Primary diagnosis is represented by schizophrenic spectrum disorders (67.5%). At 1 year follow-up, 104 patients (25.8%) were discharged: 13.6% to home, 8.2% to other RFs, 2.2% to supported housing, and 1.5% to prison.ConclusionsThe main variables associated with a higher likelihood of being discharge to home were: to have an illness duration of less than 15 years and to have an available and effective social support in the last year. Lower severity of psychopathology, and higher working skills were also associated with a significantly higher likelihood to be discharged to home.
1039 – Predictors Of Quality Of Life In a Sample Of Inpatients With Schizophrenia In 23 Residential Facilities In Northern Italy
Authors: Lanfredi M. , de Girolamo G. , Candini V. , Buizza C. , Ferrari C. , Boero M.E. , Giobbio G.M. , Goldschmidt N. , Greppo S. , Iozzino L. , Maggi P. , Melegari A.L. , Pasqualetti P. , Rossi G. 
Published: July 2013

IntroductionMany cross-sectional studies have explored the relationship between subjective QOL of people with schizophrenia and different socio-demographic characteristics, clinical and psychosocial factors. Only few studies tried to identify factors that influence the QOL of these patients using a longitudinal design.ObjectivesAim of the present study was to determine influence of clinical factors, socio-demographic variables, spirituality and satisfaction with services on QOL, to identify clinical predictors associated with quality of life at one year follow-up.Material and methodsMeasures at baseline included: demographics, BPRS, PHI, RBANS, FPS, HoNOS, SWBS, VSSS, and the Italian version of the WHOQoL-Brief. Measures at follow up included: HONOS, BPRS, FPS, WHOQoL-Brief. Logistic regression models were adopted to evaluate the association between WHOQoL-Brief scores and patient's sociodemographics, clinical characteristics, spirituality and services’ satisfaction.ResultsThe study included 171 patients: 64% males; mean age 48.7 (sd=8.9) with primary diagnosis of schizophrenia. Different domains of QOL were predicted by different indicators at baseline. Younger age, more time spending doing nothing, lower BPRS, lower satisfaction with services were explanatory variables for low quality of life in psychological facet. Spirituality and religiousness were associated with Environmental domain and VSSS was associated to all QOL domains.ConclusionsRehabilitation plans for people with schizophrenia living in RFs should pay attention to mediators of change in subjective QOL such as level of activities, social support, spirituality and satisfaction with mental health services. In particular, anxiety and depressive symptoms remain as long-term outcomes of QOL at one year follow up.
1046 – Switching To Lurasidone In Patients With Schizophrenia: Tolerability And Effectiveness At 6 Weeks And 6 Months
Authors: McEvoy J. , Citrome L. , Hsu J. , Werner P. , Pikalov A. , Cucchiaro J. , Loebel A. 
Published: July 2013

IntroductionEffectiveness studies of therapeutic switching of antipsychotics provide valuable clinical information.ObjectivesAssess effectiveness of switching patients to lurasidone.AimsTo evaluate 3 dosing strategies when switching patients to lurasidone.MethodsPatients were randomized to three open-label lurasidone dosing strategies: 40mg/day for 14 days (n=74); 40mg/day for 7 days then 80mg/day for 7 days (n=88); and 80mg/day for 14 days (n=82) and stratified by their previous treatment (sedating vs non-sedating). Prior antipsychotic was tapered (50% step-down, day 8, discontinued day 14), followed by 4 weeks of flexible dose treatment (40-120 mg/day). Primary outcome was time to treatment failure (TTF). Of the 198 subjects completing core 6-week study, 149 (75.3%) enrolled in a 6-month extension study.ResultsSwitching to lurasidone was well tolerated; 198 (81.1%) of subjects completed core study, 19 (7.9%) subjects experienced treatment failure of which 16 (6.7%) discontinued due to an AE. No clinically relevant differences were noted among the 3 dosing strategies. TTF was earlier in patients previously receiving sedating antipsychotics vs. non-sedating (log rank p=0.101). Core study yielded LS mean (SE) within-group improvement on PANSS total score -5.3 (±0.7), LOCF with further improvement of -1.5 (±0.9), LOCF, at Month 6 from extension baseline. Ninety-eight subjects (65.8%) completed extension phase. Premature discontinuation causes included consent withdrawal (12.1%) and AEs (11.4%). Weight and lipid changes at 6 months were minimal.ConclusionSwitching to lurasidone was safe and well tolerated regardless of initial dosing strategy. Switched patients maintained or improved symptom control during core and extension treatment.