bluuebunny/crossref_metadata_2025_split huggingface dataset:
The dual effect of mesenchymal stem cells on tumour growth and tumour angiogenesis
Authors: Kéramidas Michelle , de Fraipont Florence , Karageorgis Anastassia , Moisan Anaïck , Persoons Virginie , Richard Marie-Jeanne , Coll Jean-Luc , Rome Claire 
Published: April 2013

Abstract
Introduction
Understanding the multiple biological functions played by human mesenchymal stem cells (hMSCs) as well as their development as therapeutics in regenerative medicine or in cancer treatment are major fields of research. Indeed, it has been established that hMSCs play a central role in the pathogenesis and progression of tumours, but their impact on tumour growth remains controversial.

Methods
In this study, we investigated the influence of hMSCs on the growth of pre-established tumours. We engrafted nude mice with luciferase-positive mouse adenocarcinoma cells (TSA-Luc+) to obtain subcutaneous or lung tumours. When tumour presence was confirmed by non-invasive bioluminescence imaging, hMSCs were injected into the periphery of the SC tumours or delivered by systemic intravenous injection in mice bearing either SC tumours or lung metastasis.

Results
Regardless of the tumour model and mode of hMSC injection, hMSC administration was always associated with decreased tumour growth due to an inhibition of tumour cell proliferation, likely resulting from deep modifications of the tumour angiogenesis. Indeed, we established that although hMSCs can induce the formation of new blood vessels in a non-tumoural cellulose sponge model in mice, they do not modify the overall amount of haemoglobin delivered into the SC tumours or lung metastasis. We observed that these tumour vessels were reduced in number but were longer.

Conclusions
Our results suggest that hMSCs injection decreased solid tumour growth in mice and modified tumour vasculature, which confirms hMSCs could be interesting to use for the treatment of pre-established tumours.
Generic formal fibers and analytically ramified stable rings
Authors: Olberding Bruce 
Published: April 2013

AbstractLetAbe a local Noetherian domain of Krull dimensiond. Heinzer, Rotthaus, and Sally have shown that if the generic formal fiber ofAhas dimensiond– 1, thenAis birationally dominated by a 1-dimensional analytically ramified local Noetherian ring having residue field finite over the residue field ofA. We explore further this correspondence between prime ideals in the generic formal fiber and 1-dimensional analytically ramified local rings. Our main focus is on the case where the analytically ramified local rings are stable, and we show that in this case the embedding dimension of the stable ring reflects the embedding dimension of a prime ideal maximal in the generic formal fiber, thus providing a measure of how far the generic formal fiber deviates from regularity. A number of characterizations of analytically ramified local stable domains are also given.
Can Land Reform Avoid a Left Turn? Evidence from Chile after the Cuban Revolution
Authors: González Felipe 
Published: April 2013

Abstract
Following the creation of the Alliance for Progress in 1961, several structural reforms were implemented in Latin America in response to the political effects of the Cuban Revolution. Among these, land reform was arguably the most important policy. Using a unique dataset of land expropriations, and a plausible exogenous variation in land concentration, this paper studies the causal effects this policy had on political support for the incumbent party in the central government. In a context where the incumbent was losing political support (and the power of the left wing was rising), municipalities affected by land reform voted by 3–5 percentage points higher for the incumbent than municipalities not affected by this process. Although it did not prevent the first democratically elected Marxist government, land reform decreased the political support for the left wing party. I discuss several theoretical mechanisms that can explain this empirical result.
Multi-task Research and Research Joint Ventures
Authors: La Manna Manfredi M. 
Published: April 2013

AbstractThe paper shows that, whenever the completion of a research project requires the overcoming ofmore than oneresearch obstacle, then Research Joint Ventures enjoy an intrinsic advantage relative to independent firms. This advantage, which has hitherto escaped attention in the RJV literature, relates to the RJV’s ability toorganizeresearch more efficiently than independent firms. The fact that RJVs can be both more profitable and yield higher expected net welfare than independent firms is surprising because it is derived from a model in which RJVs donotoptimize over R&D investment. The paper exploits a basic result in systems reliability theory to establish the organizational superiority of RJVs.
Action-induced nested classes of groups and jump (co)homology
Authors: Petrosyan Nansen 
Published: April 2013

Abstract
Using fixed-point-free group actions, we set up a scheme to define nested classes of groups indexed over ordinals. Restricting to cellular actions on CW-complexes, we find new classes of groups as well as new characterizations for some well-known classes. We extend some of the properties of the cohomological dimension of a group to groups with jump (co)homology and study their implications to cellular actions on finite dimensional CW-complexes that satisfy a quite general homological condition.
Effectiveness of a participative community singing program to improve health behaviors and increase physical activity in Australian Aboriginal and Torres Strait Islander people
Authors: Sun Jing , Buys Nicholas 
Published: April 2013

AbstractAboriginal and Torres Strait Islander individuals continue to experience greater levels of chronic disease than the general Australian population. Evidence suggests that increased sedentary behaviors compared with the traditional healthy and active lifestyles of this population have contributed to this situation. This investigation aimed to examine the health benefits of a community-based singing activity intervention on chronic disease among Aboriginal and Torres Strait Islander Australians.From 2010 to 2011, 291 Aboriginal and Torres Strait Islander people, from Queensland, Australia, were recruited through five communities to participate in a 1-year community singing program. Participants completed a survey, in the pre- and post-intervention phases of the study, that measured social connectedness, health behavior (e.g., smoking, alcohol consumption), frequency of exercise and art activities, and medication use.Improvements in health behavior were observed for both male and female participants with chronic disease of all age groups in the community singing program. Improvements in the male and female participants included decreased social loneliness and reduced smoking behavior, increased social support, and increased participation in exercise and art activities.The participative community singing program was successful in improving the health status and increasing physical activity among Aboriginal and Torres Strait Islander adults.
Spatial Characterization of the Dynamic Response of Frequencies Utilizing Structural Partition Procedure for Large-Scale Power System
Authors: Yang Deyou 
Published: April 2013

Abstract
The aim of this paper is to present an algorithm for analysing the actual spatial characterization of the dynamic responses of frequencies for large-scale power system. Based on the distribution feature of disturbance power, the measure of interaction (MI) is employed to analyse and quantify the strength of connection among the busses and generation units. The MI takes into account the interconnection constraints among network structure and parameters. In particular, only the network parameters are used in the proposed structural partition procedure. Case Studies carried out on the IEEE 68-bus system are presented to demonstrate the application and effectiveness of the technique developed. Investigations show that the spatial characterization of the dynamic responses of frequencies can be accurately obtained with the procedure, independent of fault location and the size of disturbance, since the proposed technique is based on the structural feature of the system.
Immune activation and inflammation increase the plasma phenylalanine-to-tyrosine ratio
Authors: Geisler Simon , Gostner Johanna M. , Becker Kathrin , Ueberall Florian , Fuchs Dietmar 
Published: April 2013

Abstract
The proinflammatory cytokine interferon (IFN) γ activates GTP-cyclohydrolase I. In turn, the production of neopterin in human monocytic cells and of 5,6,7,8-tetrahydrobiopterin (BH4) in other human cells and cells of other species is markedly upregulated. BH4 is cofactor for the biosynthesis of the neurotransmitters 5-hydroxytryptamine (serotonin) and the catecholamines dopamine, epinephrine (adrenaline), and norepinephrine (noradrenaline). The finding of increased neopterin concentrations in patients with viral infections, autoimmune syndromes, malignant tumors, and during treatment with specific cytokines corresponds well with its immunobiological background. However, there is no clear information about BH4 concentrations in these patients. Furthermore, higher blood phenylalanine (Phe)-to-tyrosine (Tyr) ratios have been described in patients with ovarian cancer, after multiple trauma and with sepsis, in patients with HIV-1 infection, in elderly individuals, and in patients with HCV infection under IFN-α therapy. Recent studies already showed that the alterations of Phe metabolism are associated with mood changes and depression. Results point to an impaired hydroxylation of Phe when the enzyme phenylalanine 4-hydroxylase (PAH) is less efficient. As the decrease of PAH activity might result from a diminished availability of BH4, the determination of the Phe/Tyr ratio may serve as an indirect measure of BH4 availability.
Immune activation and inflammation in patients with cardiovascular disease are associated with elevated phenylalanine-to-tyrosine ratios
Authors: Mangge Harald , Schnedl Wolfgang J. , Schröcksnadel Sebastian , Geisler Simon , Murr Christian , Fuchs Dietmar 
Published: April 2013

Abstract
Higher serum neopterin concentrations and kynurenine-to-tryptophan (Kyn/Trp) ratios are associated with increased mortality in patients with coronary artery disease (CAD). Preferentially, Th1-type cytokine interferon-γ stimulates tryptophan breakdown and neopterin production by GTP cyclohydrolase I (GCH-I) in parallel in monocyte-derived macrophages and dendritic cells. In other cells, activation of GCH-I leads to the formation of 5,6,7,8-tetrahydrobiopterin (BH4), the necessary cofactor of amino acid hydroxylases such as phenylalanine 4-hydroxylase (PAH) and nitric oxide synthases. In 31 CAD patients (70.3±9.9 years; 21 males, 10 females), we determined serum concentrations of phenylalanine, tyrosine, and Kyn/Trp by HPLC, neopterin by ELISA, and nitrite by the colorimetric Griess assay. The phenylalanine-to-tyrosine ratio (Phe/Tyr) served as an estimate of PAH enzyme activity. Elevated Phe/Tyr concentrations were detected in a subgroup of CAD patients and correlated with Kyn/Trp (r=0.396, p<0.05) and neopterin (r=0.354, p<0.05) and inversely with nitrite (r=–0.371, p<0.05) concentrations. Higher Phe/Tyr in patients is associated with immune activation and indicates subnormal PAH activity that might be involved in the precipitation of neuropsychiatric symptoms in CAD patients.
Amino acid hexafluorosilicates – an overview
Authors: Fleck Michel , Ghazaryan Vahram V. , Petrosyan Aram M. 
Published: April 2013

Abstract
Single crystal data on eight new hexafluorosilicate salts of amino acids are presented in this work. This includes crystal and molecular structures of the following salts: 2 β-Ala · H2SiF6 (I), 2 Bet · H2SiF6 (II), 2L-Orn · H2SiF6 (III), 2L-Ser · H2SiF6 (IV), 2L-Leu · H2SiF6 · 2 H2O (V), 2L-Ile · H2SiF6 · 2 H2O (VI), 2L-Met · H2SiF6 · H2O (VII), and 2L-Asp · H2SiF6 · 2 H2O (VIII). In all these crystals, the SiF6-anion is ordered, except for (III), where disorder of the fluorine atoms occurs. An analysis of previously published data on amino acid hexafluorosilicates showed that the amount of hydrogen bonding towards the SiF6-anion is an indication of disorder – we found that all structures with 0.6 or less hydrogen bonds per fluorine atom have disorder.
Investigation of Specimen- and Grain-Size Dependence of Yield Stress in Electrodeposited Nanocrystalline Copper through Micropillar Compression
Authors: Okamoto Norihiko L. , Kashioka Daisuke , Inui Haruyuki 
Published: April 2013

ABSTRACTThe specimen-size dependence of yield stress of nanocrystalline copper with average grain size (d) of 360 nm has been investigated through uniaxial compression tests of micrometer-size pillars fabricated via the focused ion beam method. The yield stress decreases with the decrease in the micropillar size while the yield stress is almost constant for larger micropillars. The critical specimen size (t) is approximately 12.5 μm, correspoinding to the critical (t/d) value, (t/d)*, of 35, which is much larger than that for coarse-grained copper polycrystals.
Radiation resistance of nano-structured tungsten-rhenium sheet
Authors: Armstrong David E.J. , Roberts Steve G. 
Published: April 2013

ABSTRACTTungsten is one the most important material for both plasma facing and structural applications in current designs for advanced divertors. Recent work has shown that composites can be manufactured from nanostructured tungsten foils which show significantly higher toughness than monolithic tungsten, but there is no data on the radiation resistance of such materials. In this study W-5 wt% Re foil in both an as rolled and annealed condition was implanted with 2MeV W+ ions to two damage levels, 0.07 and 0.4 dpa. The change in hardness was measured using nanoindentation. An increase in hardness was seen in both materials at both damage levels, with more hardening seen for the 0.4 dpa implanted samples. However the increase in hardness due to ion implantation was 2.6 times higher in the annealed material as compared to the as rolled material. This is due to the smaller grain size and higher dislocation density providing more sinks for the irradiation produced defects in the as rolled material as compared to the annealed material. Thus showing that unannealed tungsten foils are superior for use in applications in which they will see significant levels of radiation damage.
Development of Low-Temperature Sintering Cu Nanoparticles
Authors: Ishizaki Toshitaka , Watanabe Ryota , Akedo Kunio , Satoh Toshikazu 
Published: April 2013

ABSTRACTCu nanoparticles capped with fatty acids and amines were developed as low-temperature sintering materials. The fatty acids and amines used were decanoic acid + decyl amine (C10) and oleic acid + oleyl amine (C18), respectively. The synthesized Cu nanoparticles were analyzed using X-ray diffraction, transmission electron microscopy, and thermogravimetric and differential thermal analysis. Because both of the capping layers could be decomposed at temperatures lower than 300°C even under an inert atmosphere, bonding and sintering experiments could be carried out in the absence of oxygen to prevent the oxidation of the Cu nanoparticles. The sintered structures were observed using scanning electron microscopy. The shear strengths of Cu plates bonded using the C18 Cu nanoparticles were larger than those of plates bonded using the C10 Cu nanoparticles. At 300°C, the strength was higher than 30 MPa, and of the same order as ordinary high-temperature solders, even though the processing temperature was low. The resistivity of a film sintered using the C18 Cu nanoparticles was 12 μΩcm at 300°C, which was lower than the values reported in previous studies.
Study on the Production of Silver/Modified Clay Nanocomposites
Authors: Pessanha Natália F. N. , Coelho Gerson L. V. 
Published: April 2013

ABSTRACTThe aim of this study was to investigate the application of modified clay as a support in the synthesis of silver nanoparticles. Silver nitrate (AgNO3) was used as the silver precursor in several concentrations (0.005 M, 0.01 M, 0.02 M, 0.05 M, and 0.1 M) to obtain Ag-MMT purified and modified clay nanocomposites. The properties of nanocomposites were also studied as a function of the concentration of the reducing agent, sodium borohydride (NaBH4). It was observed through X-ray Diffraction that the MMT purified structure was gradually exfoliated with increased concentrations of AgNO3, while the modified clay structure remained intact. As observed through UV-vis spectra, samples of Ag+-MMT were reduced with NaBH4 to produce Ago and its particle diameter is dependent on the concentration of NaBH4.
Multifunctional silicone nanocomposites for advanced LED encapsulation
Authors: Li Ying , Tao Peng , Siegel Richard W. , Schadler Linda S. 
Published: April 2013

ABSTRACTThe addition of high refractive index (RI) inorganic nanoparticles (NPs) to LED encapsulation materials can lead to higher light extraction efficiency. In addition, the NPs can be carriers for additional functionality such as color conversion. Using a simple “grafting-to” approach, bimodal polydimethylsiloxane (PDMS) brushes were grafted onto high-RI ZrO2 NPs. Subsequently, an organic phosphor, 6-[fluorescein-5(6)-carboxamido]hexanoic acid (FCHA), was attached onto the PDMS-grafted ZrO2 NPs via a facile ligand exchange process. The bimodal polymer brush design enables homogenous dispersion of the surface functionalized NPs within the silicone matrix. The functionalized NPs with ∼53 wt% ZrO2 core have a ∼0.08 higher RI than neat silicone, and the NP-filled silicone nanocomposites exhibit a transparency of ∼ 90% in the 550-800 nm wavelength range. In addition, the nanocomposites could be excited at a wavelength around 455 nm by a blue LED and undergo secondary yellow emission at around 571 nm. It is expected that the prepared nanocomposites can be used as high-efficiency, non-scattering, color-tuned materials for advanced LED encapsulation.
An Inventory of Crop Wild Relatives of the United States
Authors: Khoury Colin K. , Greene Stephanie , Wiersema John , Maxted Nigel , Jarvis Andy , Struik Paul C. 
Published: April 2013

ABSTRACTThe use of crop wild relatives (CWRs) in breeding is likely to continue to intensify as utilization techniques improve and crop adaptation to climate change becomes more pressing. Significant gaps remain in the conservation of these genetic resources. As a first step toward a national strategy for the conservation of CWRs, we present an inventory of taxa occurring in the United States, with suggested prioritization of species based on potential value in crop improvement. We listed 4600 taxa from 985 genera and 194 plant families, including CWRs of potential value via breeding as well as wild species of direct use for food, forage, medicine, herb, ornamental, and/or environmental restoration purposes. United States CWRs are related to a broad range of important food, forage and feed, medicinal, ornamental, and industrial crops. Some potentially valuable species are threatened in the wild, including relatives of sunflower (Helianthus annuus L.), walnut (Juglans regia L.), pepo squash (Cucurbita pepo L.), wild rice (Zizania L.), raspberry (Rubus idaeus L.), and plum (Prunus salicina Lindl.), and few accessions of such taxa are currently conserved ex situ. We prioritize 821 taxa from 69 genera primarily related to major food crops, particularly the approximately 285 native taxa from 30 genera that are most closely related to such crops. Both the urgent collection for ex situ conservation and the management of such taxa in protected areas are warranted, necessitating partnerships between concerned organizations, aligned with regional and global initiatives to conserve and provide access to CWR diversity.
The Effect of National Culture, Acculturation, and Education on Accounting Judgments: A Comparative Study of Australian and Chinese Culture
Authors: Hu Ceelsan , Chand Parmod , Evans Elaine 
Published: April 2013

ABSTRACT
We examine the influence of national culture on the judgments of Australian and Chinese tertiary accounting students when they are interpreting selected International Financial Reporting Standards (IFRSs) that contain uncertainty expressions. To extend prior cross-cultural research, we also examine whether cultural values of individuals can change because of acculturation and accounting education, and measure their potential impact on accounting judgment. The results provide strong support for the notion that Chinese accounting students are more conservative than Australian accounting students in assigning probabilities to in-context uncertainty expressions contained in IFRSs. A unique finding of this study is that the cultural values of individuals can change because of acculturation and accounting education, and this could potentially improve the comparability of financial reports by moderating differences in the interpretation of accounting standards caused by cultural differences between accountants.
Data Availability: The complete version of the research instrument is available from the second author.
Minimum inhibitory concentrations of cephalosporin compounds and their active metabolites for selected mastitis pathogens
Authors: Cortinhas Cristina S. , Oliveira Leane , Hulland Carol A. , Santos Marcos V. , Ruegg Pamela L. 
Published: April 2013

Abstract
Objective—To compare the minimum inhibitory concentration (MIC) of cephapirin and ceftiofur with MICs of their active metabolites (desacetylcephapirin and desfuroylceftiofur) for selected mastitis pathogens.
Sample—488 mastitis pathogen isolates from clinically and subclinically affected cows in commercial dairy herds in Wisconsin.
Procedures—Agar dilution was used to determine MICs for Staphylococcus aureus (n = 98), coagulase-negative staphylococci (99), Streptococcus dysgalactiae (97), Streptococcus uberis (96), and Escherichia coli (98).
Results—All S aureus isolates were susceptible to cephapirin and ceftiofur. Most coagulase-negative staphylococci were susceptible to cephapirin and ceftiofur. For E coli, 50 (51.0%; cephapirin) and 93 (94.95%; ceftiofur) isolates were susceptible to the parent compounds, but 88 (89.8%) were not inhibited at the maximum concentration of desacetylcephapirin. All S dysgalactiae isolates were susceptible to ceftiofur and cephapirin, and consistent MICs were obtained for all compounds. Most S uberis isolates were susceptible to cephapirin and ceftiofur. Of 98 S aureus isolates classified as susceptible to ceftiofur, 42 (42.9%) and 51 (52%) were categorized as intermediate or resistant to desfuroylceftiofur, respectively. For 99 coagulase-negative staphylococci classified as susceptible to ceftiofur, 45 (45.5%) and 17 (17.2%) isolates were categorized as intermediate or resistant to desfuroylceftiofur, respectively. For all staphylococci and streptococci, 100% agreement in cross-classified susceptibility outcomes was detected between cephapirin and desacetylcephapirin. No E coli isolates were classified as susceptible to desacetylcephapirin.
Conclusions and Clinical Relevance—Differences in inhibition between parent compounds and their active metabolites may be responsible for some of the variation between clinical outcomes and results of in vitro susceptibility tests.