bluuebunny/crossref_metadata_2025_split huggingface dataset:
Labyrinths and Lines of Memory in Documentary Film
Authors: Ciancio María Belén 
Published: September 2012

An examination of two Argentine documentaries that show distinct experiences of memory— Memoria del saqueo (released in English as Social Genocide, Fernando Solanas, 2004) and Los rubios (released in English as The Blonds, Albertina Carri, 2003)—in dialogue with the philosophy of Gilles Deleuze and his vision of Third World cinema as an eminently political practice reveals a tension between a linear memory that continues along the same lines as the political films of the 1960s and 1970s and a labyrinthic memory that experiments with absence in the search for recollections. Un examen de dos documentales argentinos que demuestran distintas experiencias de la memoria– Memoria del saqueo (distribuida en inglés como Social Genocide, Fernando Solanas, 2004) y Los rubios (distribuido en inglés como The Blonds, Albertina Carri, 2003)–entran en dialogo con la filosofía de Gilles Deleuze. Su visión del cinema del tercer mundo como practica eminentemente política se usa para revelar la tensión entre una memoria linear que continua la línea de las películas políticas de los 1960 y 1970, y la memoria laberíntica que experimenta con la ausencia en la búsqueda de recuerdos.
Revisiting the Argentine Political Documentary of the Late 1950s and Early 1960s
Authors: Fradinger Moira 
Published: September 2012

Criticism has tended to see the pioneer documentaries of the New Latin American Cinema in the late 1950s and early 1960s as reproducing what they denounced. Close analysis of the formal strategies of three classic Argentine films of the period—Fernando Birri’s Tire Dié, Humberto Ríos’s Faena, and Raymundo Gleyzer’s Ceramiqueros de Traslasierra—suggests, instead, that the questions and contradictions in these political documentaries are illuminated by the desire to imagine and address a new audience as an agent of social change. La crítica ha tendido a ver los documentales pioneros del Nuevo Cine Latinoamericano de la década de 1950 y comienzos de 1960 como la reproducción de lo que denunciaban. Un análisis más detallado de las estrategias formales de tres clásicos del cine argentino de la época— Tire Dié de Fernando Birri, Faena de Humberto Ríos, y Ceramiqueros de Traslasierra de Raymundo Gleyzer—sugiere, en cambio, que las cuestiones y contradicciones en estos documentales políticos son clarificadas por el deseo de imaginar y dirigirse a una nueva audiencia entendida como un agente de cambio social.
Framing Ruins
Authors: Rodríguez Juan Carlos 
Published: September 2012

The representations of ruins in three of Patricio Guzmán’s postdictatorial documentaries— Chile, la memoria obstinata (1997), La isla de Robinson Crusoe (1999), and El caso Pinochet (2001)—can be seen as allegories of different aspects of Chilean history: the defeat of Allende’s democratic alliance, the end of the Pinochet regime, and the challenges of social reconciliation in contemporary Chile. Guzmán’s strategy of screening architectonic ruins evokes the ruin of the socialist and dictatorial regimes in Chile. The filmmaker also presents a second image of ruin that evokes the ruin of the screen and, in this way, confronts viewers with the limits of representation, language, reconciliation, and testimony. Las representaciones de ruinas en tres de los documentales de la posdictadura de Patricio Guzmán— Chile, la memoria obstinada (1997), La isla de Robinson Crusoe (1999), y Le cas Pinochet (2001)—pueden verse como alegóricas de aspectos distintos de la historia de Chile: la derrota de la Alianza Democrática de Allende, el fin del régimen de Pinochet, y los retos de la reconciliación social en el Chile contemporáneo. La estrategia de Guzmán de proyectar ruinas arquitectónicas evoca la ruina de los regimenes socialistas y dictatoriales en Chile. También se presenta otro imagen de ruina que evoca la ruina de la pantalla, de modo de que se elaboran los limites de la representación, la lengua, la reconciliación, y el testimonio.
Terminal myeloid differentiation in vivo is induced by FLT3 inhibition in FLT3/ITD AML
Authors: Sexauer Amy , Perl Alexander , Yang Xiaochuan , Borowitz Michael , Gocke Christopher , Rajkhowa Trivikram , Thiede Christian , Frattini Mark , Nybakken Grant E. , Pratz Keith , Karp Judith , Smith B. Douglas , Levis Mark 
Published: September 2012

Abstract
A hallmark of cancer is the disruption of differentiation within tumor cells. Internal tandem duplication mutations of the FLT3 kinase (FLT3/ITD) occur commonly in acute myeloid leukemia (AML) and are associated with poor survival, leading to efforts to develop FLT3 kinase inhibitors. However, FLT3 inhibitors have thus far met with limited success, inducing only a clearance of peripheral blasts with minimal BM responses. Quizartinib is a novel potent and selective FLT3 inhibitor currently being studied in clinical trials. In 13 of 14 FLT3/ITD AML patients with normal karyotype treated with quizartinib, we observed terminal myeloid differentiation of BM blasts in association with a clinical differentiation syndrome. The single patient whose blasts failed to differentiate had a preexisting C/EBPα mutation and another developed a C/EBPα mutation at disease progression, suggesting a mechanism of resistance to FLT3 inhibition. In vitro, in primary blasts cocultured with human BM stroma, FLT3 inhibition with quizartinib induced cell-cycle arrest and differentiation rather than apoptosis. The present study is the first description of terminal differentiation of cancer cells in patients treated with a tyrosine kinase inhibitor. These data highlight the importance of the differentiation block in the patho-genesis of AML.
Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
Authors: Perales Miguel-Angel , Goldberg Jenna D. , Yuan Jianda , Koehne Guenther , Lechner Lauren , Papadopoulos Esperanza B. , Young James W. , Jakubowski Ann A. , Zaidi Bushra , Gallardo Humilidad , Liu Cailian , Rasalan Teresa , Wolchok Jedd D. , Croughs Therese , Morre Michel , Devlin Sean M. , van den Brink Marcel R. M. 
Published: September 2012

AbstractDelays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs. Twelve patients were treated with escalating doses of r-hIL-7 administered weekly for 3 weeks. The study drug was well tolerated with only one patient developing acute skin GVHD. At baseline, patients were profoundly lymphopenic. CYT107 induced a doubling in CD4+ and CD8+ T cells. The main effect of IL-7 was an expansion of effector memory T cells, the predominant subset identified in our patients. There was no significant effect on CD4+CD25+FoxP3+ T cells, NK, or B cells. Importantly, we not only saw quantitative increases in T cells after a short course of IL-7 but also demonstrated an increase in functional T cells, including viral-specific T cells that recognize CMV. Enhanced TCR diversity was also observed after treatment. Our results indicate that r-hIL-7 can enhance immune recovery after a T cell–depleted allo-HSCT without causing significant GVHD or other serious toxicity (www.clinicaltrials.gov; NCT00684008).
An algorithm for chemical genomic profiling that minimizes batch effects: bucket evaluations
Authors: Shabtai Daniel , Giaever Guri , Nislow Corey 
Published: September 2012

AbstractBackgroundChemical genomics is an interdisciplinary field that combines small molecule perturbation with traditional genomics to understand gene function and to study the mode(s) of drug action. A benefit of chemical genomic screens is their breadth; each screen can capture the sensitivity of comprehensive collections of mutants or, in the case of mammalian cells, gene knock-downs, simultaneously. As with other large-scale experimental platforms, to compare and contrast such profiles, e.g. for clustering known compounds with uncharacterized compounds, a robust means to compare a large cohort of profiles is required. Existing methods for correlating different chemical profiles include diverse statistical discriminant analysis-based methods and specific gene filtering or normalization methods. Though powerful, none are ideal because they typically require one to define the disrupting effects, commonly known as batch effects, to detect true signal from experimental variation. These effects are not always known, and they can mask true biological differences. We present a method, Bucket Evaluations (BE) that surmounts many of these problems and is extensible to other datasets such as those obtained via gene expression profiling and which is platform independent.ResultsWe designed an algorithm to analyse chemogenomic profiles to identify potential targets of known drugs and new chemical compounds. We used levelled rank comparisons to identify drugs/compounds with similar profiles that minimizes batch effects and avoids the requirement of pre-defining the disrupting effects. This algorithm was also tested on gene expression microarray data and high throughput sequencing chemogenomic screens and found the method is applicable to a variety of dataset types.ConclusionsBE, along with various correlation methods on a collection of datasets proved to be highly accurate for locating similarity between experiments. BE is a non-parametric correlation approach, which is suitable for locating correlations in somewhat perturbed datasets such as chemical genomic profiles. We created software and a user interface for using BE, which is publically available.
A systematic review of symptom assessment scales in children with cancer
Authors: Dupuis L Lee , Ethier Marie-Chantal , Tomlinson Deborah , Hesser Tanya , Sung Lillian 
Published: September 2012

Abstract

Background
The objective was to describe symptom assessment scales that have been used in children with cancer.

Methods
We conducted electronic searches of OVID Medline and EMBASE in order to identify all symptom assessment scales that have been used in pediatric cancer. Two reviewers abstracted information from each identified study. Data collected included study demographics and information related to the instrument and children enrolled. We also collected information about the purpose of instrument administration and whether treatment was altered as a result of this information.

Results
Fourteen studies were identified which evaluated eight different symptom assessment scales. Eight studies used child self-report and all studies included children on active treatment for cancer although 4 studies also included children following completion of treatment. The most common purpose of instrument administration was to measure the prevalence of symptom burden (n = 8). None of the 14 studies used the scale to screen for symptoms and none changed patient management on the basis of identified symptoms.

Conclusions
We failed to identify any symptom assessment scales that were used as a symptom screening tool. There is a need to develop such a tool for use in children with cancer.
An urea, arginine and carnosine based cream (Ureadin Rx Db ISDIN) shows greater efficacy in the treatment of severe xerosis of the feet in Type 2 diabetic patients in comparison with glycerol-based emollient cream. A randomized, assessor-blinded, controlled trial
Authors: Federici Adalberto , Federici Giovanni , Milani Massimo 
Published: September 2012

Abstract

Background
Xerosis is a common skin disorder frequently observed in diabetic patients. An effective hydration of foot skin in diabetics is a relevant preventive strategy in order to maintain a healthy foot. Urea is considered an effective hydrating and emollient topical product. The aim of the present study was to evaluate the efficacy of topical urea 5% with arginine and carnosine (Ureadin Rx Db, ISDIN Spain) (UC) in comparison with glycerol-based emollient topical product (Dexeryl, Pierre Fabre) (EC), in Type 2 diabetic patients.

Methods
We assessed the effect of UC on skin hydration in a randomized, evaluator-blinded comparative study in 40 type II diabetic patients, aged 40–75 years, treated with UC or the comparator for 28 days with a twice-daily application. The principal outcomes were the Dryness Area Severity Index (DASI) Score and the Visual Analogue Score (VAS) for skin dryness evaluated at baseline and at the end of study period by an investigator unaware of treatment allocation.

Results
UC induced significantly greater hydration than EC with an 89% reduction in DASI score (from 1.6 to 0.2; p < 0.001) in comparison with baseline values. After 4 weeks, compared with the control group, DASI score in UC treated group was significantly lower (0.2 vs. 1.0; p = 0.048). VAS score (high values mean better hydration) significantly increased in both groups during treatment. VAS score at the end of treatment period was significantly higher in UC group in comparison with EC group (9.8 vs. 8.2; p = 0.05).

Conclusion
Application of urea 5%, arginine and carnosine cream increases skin hydration and alleviates the condition of skin dryness in Type 2 diabetic patients in comparison with a control glycerol-based emollient product. (Dutch Trials Register trial number 3328).
Design of a prostate cancer patient navigation intervention for a Veterans Affairs hospital
Authors: Nonzee Narissa J , McKoy June M , Rademaker Alfred W , Byer Peter , Luu Thanh Ha , Liu Dachao , Richey Elizabeth A , Samaras Athena T , Panucci Genna , Dong XinQi , Simon Melissa A 
Published: September 2012

Abstract

Background
Patient navigation programs have been launched nationwide in an attempt to reduce racial/ethnic and socio-demographic disparities in cancer care, but few have evaluated outcomes in the prostate cancer setting. The National Cancer Institute-funded Chicago Patient Navigation Research Program (C-PNRP) aims to implement and evaluate the efficacy of a patient navigation intervention for predominantly low-income minority patients with an abnormal prostate cancer screening test at a Veterans Affairs (VA) hospital in Chicago.

Methods/Design
From 2006 through 2010, C-PNRP implemented a quasi-experimental intervention whereby trained social worker and lay health navigators worked with veterans with an abnormal prostate screen to proactively identify and resolve personal and systems barriers to care. Men were enrolled at a VA urology clinic and were selected to receive navigated versus usual care based on clinic day. Patient navigators performed activities to facilitate timely follow-up such as appointment reminders, transportation coordination, cancer education, scheduling assistance, and social support as needed. Primary outcome measures included time (days) from abnormal screening to diagnosis and time from diagnosis to treatment initiation. Secondary outcomes included psychosocial and demographic predictors of non-compliance and patient satisfaction. Dates of screening, follow-up visits, and treatment were obtained through chart audit, and questionnaires were administered at baseline, after diagnosis, and after treatment initiation. At the VA, 546 patients were enrolled in the study (245 in the navigated arm, 245 in the records-based control arm, and 56 in a subsample of surveyed control subjects).

Discussion
Given increasing concerns about balancing better health outcomes with lower costs, careful examination of interventions aimed at reducing healthcare disparities attain critical importance. While analysis of the C-PNRP data is underway, the design of this patient navigation intervention will inform other patient navigation programs addressing strategies to improve prostate cancer outcomes among vulnerable populations.
A case of wedge resection of duodenum for massive gastrointestinal bleeding due to duodenal metastasis by renal cell carcinoma
Authors: Zhao Hongzhi , Han Keqiang , Li Jing , Liang Ping , Zuo Guohua , Zhang Yu , Li Hongyan 
Published: September 2012

AbstractBackgroundGastrointestinal bleeding due to duodenal metastasis from renal cell carcinoma is extremely rare. Several previous reports have shown that embolic therapy or pancreatoduodenectomy (radical surgical resection) could be effective in controlling this type of clinical complication. Management is entirely dependent on the general condition and concurrent metastases at other sites. Optimizing the therapeutic strategies thus deserves further discussion and exploration.MethodsIn this report, we describe a patient with severe co-morbidities who underwent successful palliative wedge resection of duodenum and direct duodenal wall defect repair without reconstruction of duodeno-jejunostomy for acute upper digestive tract hemorrhage caused by duodenal metastasis from renal clear cell carcinoma.ResultsThe patient recovered uneventfully and did not experience rebleeding and frequent vomiting after surgery. Since then (1.5 years) he has had no evidence of rebleeding.ConclusionsGastrointestinal bleeding due to duodenal metastasis of RCC may benefit from emergent resection even in the presence of severe co-morbidities, and for palliative treatment.
Microplasma illumination enhancement of vertically aligned conducting ultrananocrystalline diamond nanorods
Authors: Sankaran Kamatchi Jothiramalingam , Kunuku Srinivasu , Lou Shiu-Cheng , Kurian Joji , Chen Huang-Chin , Lee Chi-Young , Tai Nyan-Hwa , Leou Keh-Chyang , Chen Chulung , Lin I-Nan 
Published: September 2012

Abstract
Vertically aligned conducting ultrananocrystalline diamond (UNCD) nanorods are fabricated using the reactive ion etching method incorporated with nanodiamond particles as mask. High electrical conductivity of 275 Ω·cm−1 is obtained for UNCD nanorods. The microplasma cavities using UNCD nanorods as cathode show enhanced plasma illumination characteristics of low threshold field of 0.21 V/μm with plasma current density of 7.06 mA/cm2 at an applied field of 0.35 V/μm. Such superior electrical properties of UNCD nanorods with high aspect ratio potentially make a significant impact on the diamond-based microplasma display technology.
Detection of nerve agent stimulants based on photoluminescent porous silicon interferometer
Authors: Kim Seongwoong , Cho Bomin , Sohn Honglae 
Published: September 2012

Abstract
Porous silicon (PSi) exhibiting dual optical properties, both Fabry-Pérot fringe and photolumincence, was developed and used as chemical sensors. PSi samples were prepared by an electrochemical etch of p-type silicon under the illumination of 300-W tungsten lamp during the etch process. The surface of PSi was characterized by cold field-emission scanning electron microscope. PSi samples exhibited a strong visible orange photoluminescence at 610 nm with an excitation wavelength of 460 nm as well as Fabry-Pérot fringe with a tungsten light source. Both reflectivity and photoluminescence were simultaneously measured under the exposure of organophosphate vapors. An increase of optical thickness and quenching photoluminescences under the exposure of various organophosphate vapors were observed.
Antibacterial therapeutics for the treatment of chytrid infection in amphibians: Columbus’s egg?
Authors: Muijsers Mariska , Martel An , Van Rooij Pascale , Baert Kris , Vercauteren Griet , Ducatelle Richard , De Backer Patrick , Vercammen Francis , Haesebrouck Freddy , Pasmans Frank 
Published: September 2012

AbstractBackgroundThe establishment of safe and effective protocols to treat chytridiomycosis in amphibians is urgently required. In this study, the usefulness of antibacterial agents to clear chytridiomycosis from infected amphibians was evaluated.ResultsFlorfenicol, sulfamethoxazole, sulfadiazine and the combination of trimethoprim and sulfonamides were activein vitroagainst cultures of fiveBatrachochytrium dendrobatidisstrains containing sporangia and zoospores, with minimum inhibitory concentrations (MIC) of 0.5-1.0 μg/ml for florfenicol and 8.0 μg/ml for the sulfonamides. Trimethoprim was not capable of inhibiting growth but, combined with sulfonamides, reduced the time to visible growth inhibition by the sulfonamides. Growth inhibition ofB. dendrobatidiswas not observed after exposure to clindamycin, doxycycline, enrofloxacin, paromomycin, polymyxin E and tylosin. Cultures of sporangia and zoospores ofB. dendrobatidisstrains JEL423 and IA042 were killed completely after 14 days of exposure to 100 μg/ml florfenicol or 16 μg/ml trimethoprim combined with 80 μg/ml sulfadiazine. These concentrations were, however, not capable of efficiently killing zoospores within 4 days after exposure as assessed using flow cytometry. Florfenicol concentrations remained stable in a bathing solution during a ten day period. Exposure ofDiscoglossus scovazzitadpoles for ten days to 100 μg/ml but not to 10 μg florfenicol /ml water resulted in toxicity. In anin vivotrial, post metamorphicAlytes muletensis, experimentally inoculated withB. dendrobatidis,were treated topically with a solution containing 10 μg/ml of florfenicol during 14 days. Although a significant reduction of theB. dendrobatidisload was obtained, none of the treated animals cleared the infection.ConclusionsWe thus conclude that, despite marked antiB. dendrobatidisactivityin vitro, the florfenicol treatment used is not capable of eliminatingB. dendrobatidisinfections from amphibians.
Tamm-Horsfall protein facilitates catheter associated urinary tract infection
Authors: Raffi Hajamohideen S , Bates James M , Flournoy Dayl J , Kumar Satish 
Published: September 2012

Abstract

Background
Urinary catheters are associated, commonly with bacteriuria and frequently with urinary tract infection. Tamm-Horsfall Protein (THP) is urine's most abundant protein and is known to bind to uropathogenic bacteria. The role of THP in the pathogenesis of catheter associated urinary tract infection (CAUTI) is not clear. We examined the role of THP in facilitating bacterial binding to urinary catheters in vivo and in vitro.

Findings
Twenty one urinary catheters were obtained from 20 hospitalized patients. THP was eluted from the catheter surface and catheter segments were cultured. Additional studies were performed in vitro on unused silicone and latex catheters to determine the binding of THP, and the effect of THP on the binding of Escherichia coli (E. coli) and Pseudomonas aeruginosa (P. aeruginosa), to the catheter surface.
On catheters obtained from patients, the THP deposition was significantly more on culture positive catheters than on culture negative catheters. In the in vitro studies, THP bound to both silicone and latex catheters, and THP enhanced the adherence of E. coli and P. aeruginosa to both types of catheters.

Conclusion
THP binds to urinary catheters and facilitates the binding of uropathogenic bacteria to catheters.