bluuebunny/crossref_metadata_2025_split huggingface dataset:
Embracing CSR in pro-social relationship marketing program: understanding driving forces of positive consumer responses
Authors: Hwang Jiyoung , Kandampully Jay 
Published: July 2015

Purpose
– This purpose of this article is to identify important factors that influence consumers’ responses to pro-social loyalty programs (pro-social LPs). These positive marketing programs reflect represent an emerging phenomenon in relationship marketing associated with companies’ corporate social responsibility (CSR).

Design/methodology/approach
– The test of the proposed model relied on data from 350 US consumers, obtained through web-based experiments. Data analysis was performed using structural equation modeling.

Findings
– The results showed that consumers’ CSR-driven cognition (CSR beliefs) and reciprocal emotion (feeling of gratitude) enhance their attitudes toward pro-social LPs and increased participation intentions. The perceived value of pro-social LPs also improved consumer attitudes and participation intentions.

Practical implications
– Pro-social LPs offer a noteworthy approach to relationship marketing that benefits both service providers that engage in CSR and society overall.

Originality/value
– This study contributes to the literature on LP and CSR by investigating the roles of CSR-driven cognition, reciprocal emotion and value perception in explaining consumers’ responses to an innovative approach of LPs and pro-social LPs.
Factors influencing consumers’ attitudes and purchase intentions of e-deals
Authors: Cheah Isaac , Phau Ian , Liang Johan 
Published: July 2015

Purpose
– The purpose of this paper is to identify the key antecedents of attitude towards electronic deals (e-deals) and factors influencing purchase intention of e-deals. Specifically, perceived value and price consciousness will be tested as antecedents of attitudes towards e-deals. Attitudes towards e-deals, subjective norms, and perceived behavioural control are proposed to have strong influences upon purchase intention. The theory of planned behaviour (TPB) provides the theoretical underpinning of the conceptual framework.

Design/methodology/approach
– Data were collected through convenience sampling. Overall, 611 valid responses of 780 distributed surveys were collected. Only 426 e-deals users were analysed by using structural equation modelling to test the hypotheses.

Findings
– It is found that perceived value is a strong predictor of attitudes towards e-deals. Another finding also indicates that attitudes towards e-deals and normative influence positively affect consumers’ purchase intention towards e-deals.

Practical implications
– Practitioners are advised to integrate social media (e.g. Facebook or Twitter) and online communities to approach the “leader” to influence new potential consumers to purchase e-deals. It is also important to maintain the good value of e-deals and emphasise the huge benefits of using e-deals to persuade consumers to purchase it.

Originality/value
– The originality of this study lies in extending the TPB as a robust measurement to investigate online shopping behaviour in the context of e-deals.
Natural hybridization of Yezo and Sakhalin spruce in central Hokkaido, revealed by DNA markers with contrasting modes of inheritance
Authors: Aizawa Mineaki , Yoshimaru Hiroshi , Ogawa Hitomi , Goto Susumu , Kaji Mikio 
Published: July 2015

AbstractYezo spruce (Picea jezoensis var. jezoensis) and Sakhalin spruce (Picea glehnii) occur across Hokkaido and co‐occur in some forest habitats. This leads to the potential for natural hybridization between these two species, which has been shown to occur at low frequencies. The purpose of this study was to identify these hybrids and their possible mating patterns, using various Pinaceae DNA markers with different modes of inheritance. The markers used were maternally inherited mitochondrial DNA (mtDNA), paternally inherited chloroplast DNA (cpDNA) and biparentally inherited nuclear microsatellites (nSSRs). Seven putative natural hybrids, four artificially‐crossed F1 hybrids, four parent plants from each species, and two artificially‐backcrossed hybrids of putative natural hybrids and their parents were analyzed using the diagnostic DNA markers developed in this study. We found Yezo spruce and Sakhalin spruce to be distinct (J and G types, respectively), and the modes of inheritance held true for the two species, as was previously reported to be the case in Pinaceae. Four of the seven putative natural hybrids harbored J‐type cpDNA, G‐type mtDNA and J/G‐type nSSRs, indicating that natural F1 hybrids are likely to arise from a G (female) × J (male) crossing. One natural hybrid harbored G‐type cpDNA, J‐type mtDNA and J/G‐type nSSRs, which implies that hybrids produced by J (female) × G (male) crossings occur at low frequencies. The two remaining hybrids harbored J‐type cpDNA and mtDNA with either J/G or J/J‐type nSSRs, suggesting that they may be F2 hybrids resulting from backcrossing between an F1 hybrid and a Yezo spruce.
Nonalcoholic Steatohepatitis Score is an Independent Predictor of Right Ventricular Dysfunction in Patients with Nonalcoholic Fatty Liver Disease
Authors: Sunbul Murat , Kivrak Tarik , Durmus Erdal , Akin Hakan , Aydin Yucel , Ergelen Rabia , Yilmaz Yusuf , Agirbasli Mehmet 
Published: July 2015

SummaryObjectiveNonalcoholic fatty liver disease (NAFLD) is associated with increased risk of cardiovascular disease and impaired left ventricular (LV) function, yet the impact of NAFLD on right ventricular (RV) function remains unclear. We investigate the RV functional properties in patients with NAFLD.MethodsNinety consecutive patients with the diagnosis of biopsy‐proven NAFLD and 45 age‐ and sex‐matched controls were included. All patients underwent an echocardiographic examination. RV function was evaluated by two‐dimensional (2D) speckle‐tracking echocardiography (STE).ResultsMean fibrosis stage and nonalcoholic steatohepatitis (NASH) scores were 1.3 ± 1.1 and 5.2 ± 1.6, respectively. NAFLD patients displayed decreased RV function compared to controls. NAFLD patients with liver fibrosis (67 patients) had significantly lower RV function assessed by GLS (global longitudinal strain) compared to patients without liver fibrosis (18.9 ± 3.4% vs. 21.6 ± 2.3%, P < 0.001). NASH score ≥5 was associated with lower RV‐GLS (18.9 ± 3.1% vs. 21.0 ± 3.4%, P = 0.006). NASH score inversely correlated with RV‐GLS (r = −0.370, P < 0.001) such as patients with impaired RV‐GLS (<19%) showed significantly higher NASH score compared to normal RV‐GLS group (5.8 ± 1.4 vs. 4.8 ± 1.7, P = 0.009). Logistic regression analysis revealed that NASH score was an independent predictor of impaired RV function in patients with NAFLD.ConclusionsPatients with NAFLD have impaired RV function. NASH score inversely correlates with RV‐GLS and independently predicts impaired RV function in patients with NAFLD.
Dendritic cell‐derived exosomes carry the major cat allergen Fel d 1 and induce an allergic immune response
Authors: Vallhov H. , Gutzeit C. , Hultenby K. , Valenta R. , Grönlund H. , Scheynius A. 
Published: July 2015

AbstractExosomes are nano‐sized membrane vesicles (50–120 nm), which are released from a wide variety of cells. Depending on their cellular origin, they can induce immune stimulatory‐, inhibitory‐, or tolerance‐inducing effects. However, it is still unclear what role exosomes play during human inflammatory diseases. It has not been studied whether exosomes derived from human dendritic cells (DCs), the first cells to encounter allergens in the mucosa, can carry aeroallergens and contribute to allergic immune responses. We therefore explored whether DC‐derived exosomes can present the major cat allergen Fel d 1 and whether they thereby contribute to the pathogenesis of allergic disease. Our results demonstrate that exosomes are able to present aeroallergens and thereby induce T‐cell T(H)2‐like cytokine production in allergic donors. Thus, these exosomes may be important immune‐stimulatory factors in allergic immune responses and important targets or engineered tools in immunotherapy.
Violence, legitimacy, and prophecy: Nuer struggles with uncertainty in South Sudan
Authors: HUTCHINSON SHARON E. , PENDLE NAOMI R. 
Published: July 2015

ABSTRACTContemporary South Sudanese Nuer prophets play powerful roles in interpreting the moral limits of lethal violence and weighing the legitimacy claims of rival government leaders. Their activities remain largely invisible to external observers investigating the making and unmaking of fragile states. Focusing on South Sudan's tumultuous 2005–14 period, we reveal these hidden dynamics through analysis of the two most‐powerful living western Nuer prophets. Gatdeang Dit, a male prophet of the divinityDeng, rejects all forms of violent aggression and fosters relations of peace and intermarriage with Dinka neighbors. Nyachol, a female prophet ofMaani, inspires thousands of armed Nuer youth to retaliate against Dinka cattle raiders and other external threats while insisting on purification for Nuer–Nuer homicides. Despite their differences, both prophets invoke God's superior powers to push back against the simplified, secularized, and objectified forms of violence glorified by rival government elites. [prophecy, government, violence, legitimacy, uncertainty, Nuer, South Sudan]
Automated control of inspired oxygen in ventilated preterm infants: crossover physiological study
Authors: Lal Mithilesh , Tin Win , Sinha Sunil 
Published: July 2015

AbstractAimTo evaluate the efficacy of automated control of the fraction of inspired oxygen (FiO2) in comparison with manual FiO2 control in maintaining target pulse oxygen saturation (SpO2) range.MethodsCrossover physiological study involving preterm infants requiring mechanical ventilation and supplemental oxygen. Each infant was studied for two consecutive 12 hours in a random sequence. Outcome measures included the proportion of time with SpO2 within and outside the target range of 90–95%, extreme hypoxaemia (<80%) and hyperoxaemia (≥98%).ResultsComplete data set was available in 27 infants. The percentage of time (median, IQR) within the target range was higher during automated control 72.8 (58.8–82.6) compared to manual control 59.6 (49.3–73.3), p = 0.031. Corresponding reduction in per cent time below the target range was 18.1 (12.7–23.6) versus 25.9 (17.8–30.7), p = 0.028, and above the target range 4.8 (3–16) versus 10.1 (6.4‐22.5), p = 0.026. Median (IQR) per cent time spent with severe hypoxaemia (SpO2<80%) and severe hyperoxaemia (SpO2≥98%) was 1.3 (0.1–2.9) versus 3.2 (1.4–6.1), p = 0.022 and 0.08 (0.05–0.36) versus 1.7 (0.7–6.8), p = 0.001, respectively. Median number of manual adjustments of FiO2 per 12 hour was 0 and 63, respectively.ConclusionAutomated control of FiO2 significantly improved compliance of oxygen saturation targeting and significantly reduced exposure to hypoxaemia as well as hyperoxaemia.
Acid‐inhibitory effects of vonoprazan 20 mg compared with esomeprazole 20 mg or rabeprazole 10 mg in healthy adult male subjects ‐ a randomised open‐label cross‐over study
Authors: Sakurai Y. , Mori Y. , Okamoto H. , Nishimura A. , Komura E. , Araki T. , Shiramoto M. 
Published: July 2015

SummaryBackgroundProton pump inhibitors (PPIs) are widely used for the treatment of acid‐related diseases. Vonoprazan is a member of a new class of acid suppressants; potassium‐competitive acid blockers. Vonoprazan may thus be an alternative to PPIs.AimTo evaluate efficacy, rapidity and duration of acid‐inhibitory effects of vonoprazan vs. two control PPIs, esomeprazole and rabeprazole, in 20 healthy Japanese adult male volunteers with CYP2C19 extensive metaboliser genotype.MethodsIn this randomised, open‐label, two‐period cross‐over study, vonoprazan 20 mg and esomeprazole 20 mg (Study V vs. E) or rabeprazole 10 mg (Study V vs. R) were orally administered daily for 7 days. Primary pharmacodynamic endpoint was gastric pH over 24 h measured as percentage of time pH ≥3, ≥4 and ≥5 (pH holding time ratios; HTRs) and mean gastric pH.ResultsAcid‐inhibitory effect (pH4 HTR) of vonoprazan was significantly greater than that of esomeprazole or rabeprazole on both Days 1 and 7; Day 7 difference in pH4 HTR for vonoprazan vs. esomeprazole was 24.6% [95% confidence interval (CI): 16.2–33.1] and for vonoprazan vs. rabeprazole 28.8% [95% CI: 17.2–40.4]. The Day 1 to Day 7 ratio of 24‐h pH4 HTRs was >0.8 for vonoprazan, compared with 0.370 for esomeprazole and 0.393 for rabeprazole. Vonoprazan was generally well tolerated. One vonoprazan subject withdrew due to a rash which resolved after discontinuation.ConclusionsThis study demonstrated a more rapid and sustained acid‐inhibitory effect of vonoprazan 20 mg vs. esomeprazole 20 mg or rabeprazole 10 mg. Therefore, vonoprazan may be a potentially new treatment for acid‐related diseases.
Natural history and quality of life in patients with cystine urolithiasis: a single centre study
Authors: Parr Justin M. , Desai Devang , Winkle David 
Published: July 2015

ObjectiveTo describe the natural history and quality of life (QoL) in patients with cystine urolithiasis.Patients and MethodsA cohort study was carried out involving participants recruited from a single surgeon's case mix. Patients with cystinuria and related urolithiasis were invited to complete a questionnaire involving demographic information, use of medical treatment, surgical interventions and the 36‐item short‐form 36‐item short‐form health survey (SF‐36).ResultsIn all, 14 patients completed the survey. The SF‐36 survey showed lower QoL than the general public in seven of eight domains. The mean interventional rate in patients with cystinuria was 10.6 procedures per patient. Most patients reported previous use of d‐penicillamine and urinary alkalinisation medications, with most ceasing due to side‐effects or lack of perceived efficacy.ConclusionCystinuria is associated with a high rate of surgical intervention and lower QoL than the general public. Individuals with this condition report that medical management is either ineffective or poorly tolerated. There is a need for further improvements in medical management of cystinuria, to reduce the rate of operative intervention.
Metabolomics analysis of saliva from patients with primary Sjögren's syndrome
Authors: Kageyama G , Saegusa J , Irino Y , Tanaka S , Tsuda K , Takahashi S , Sendo S , Morinobu A 
Published: July 2015

Summary
The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this disease. We obtained salivary samples from 12 female pSS patients (mean age 44.2 ± 13.01) and 21 age-matched female HCs. The metabolite profiles of saliva were analysed by gas chromatography-mass spectrometry. The total metabolite levels in each of the samples were calculated and compared across the study participants. A total of 88 metabolites were detected across the study samples, 41 of which were observed at reduced levels in the samples frompSS patients. Principal component analysis (PCA) revealed a loss in salivary metabolite diversity in the pSS patient samples compared to the HC samples. The reduced presence of glycine, tyrosine, uric acid and fucose, which may reflect salivary gland destruction due to chronic sialoadenitis, contributed to the loss of diversity. Comparative PCA of the pSS patients revealed the presence of two subpopulations based on their metabolite profiles, and these two subpopulations showed a significant difference in the prevalence of major salivary glanditis (P = 0·014). In this study, we found that the salivary metabolite profile of pSS patients was less diverse than that of HCs and that the metabolite profiles in pSS patients were affected by the presence of major salivary glanditis.
RNA binding proteins as regulators of immune cell biology
Authors: Newman R , McHugh J , Turner M 
Published: July 2015

Summary
Sequence-specific RNA binding proteins (RBP) are important regulators of the immune response. RBP modulate gene expression by regulating splicing, polyadenylation, localization, translation and decay of target mRNAs. Increasing evidence suggests that RBP play critical roles in the development, activation and function of lymphocyte populations in the immune system. This review will discuss the post-transcriptional regulation of gene expression by RBP during lymphocyte development, with particular focus on the Tristetraprolin family of RBP.
Clinical outcomes in patients with nonfunctioning pituitary adenomas managed conservatively
Authors: Sam Amir H. , Shah Sachit , Saleh Keenan , Joshi Jay , Roncaroli Federico , Robinson Stephen , Cox Jeremy , Martin Niamh M. , Mendoza Nigel , Meeran Karim , Mehta Amrish , Dhillo Waljit S. 
Published: July 2015

SummaryContextThe natural history and the optimum management of patients with nonfunctioning pituitary adenomas (NFPAs) are unclear.ObjectiveOur objective was to characterize the natural history of patients with NFPAs managed conservatively.Design and patientsWe conducted a retrospective analysis of patients presenting to a tertiary referral centre between 1986 and 2009. Patients with pituitary adenomas and no clinical or biochemical evidence of hormonal hypersecretion were included. Those presenting with apoplexy or a radiological follow‐up period of less than 1 year were excluded. The pituitary imaging for all patients was re‐examined by two neuroradiologists in consensus.Outcome measuresThe outcome measures were change in tumour size and pituitary hormone function.ResultsSixty‐six patients were managed conservatively for a mean follow‐up period of 4·3 years (range: 1–14·7). Forty‐seven (71%) had a macroadenoma, and nineteen (29%) had a microadenoma. Tumour size decreased or remained stable in 40% of macroadenomas and 47% of microadenomas. The median annual growth rate of enlarging macroadenomas and microadenomas was 1·0 mm/year and 0·4 mm/year, respectively. The median annual growth rate of macroadenomas was significantly higher than that of microadenomas (P < 0·01). Sixty‐eight percentage of patients with a macroadenoma had pituitary hormone deficiency in one or more axes, compared to 42% of those with a microadenoma.ConclusionPatients with NFPAs without optic chiasm compression can be managed conservatively. All patients need pituitary function assessment, irrespective of tumour size. These findings provide clinically relevant data for the management of patients with NFPAs.
The hidden costs of drug and alcohol use in hospital emergency departments
Authors: Butler Kerryn , Reeve Rebecca , Arora Sheena , Viney Rosalie , Goodall Stephen , van Gool Kees , Burns Lucinda 
Published: July 2015

AbstractIntroduction and AimsThis study estimates the burden of drug and alcohol morbidity on hospitals in New South Wales (NSW) by observing a multi‐site collective sample utilising survey information and data linkage. Specifically we aimed to determine the prevalence of alcohol and other drug (AOD) problems and to estimate patterns of utilisation of hospital services, costs of presentations, and admissions for patients with AOD problems.Design and MethodsPatients were recruited from eight NSW public hospitals presenting to the hospital emergency department over a 10 day period. Participants completed a self‐administered survey with demographic characteristics and questions about substance use. More than two‐thirds (68%) of participants consented to provide access to their NSW Health medical data for a period spanning 2.5 years.ResultsOne‐third (35%) of the total sample were identified as having problematic AOD use with one in five of these patients requiring a high level of intervention. Those patients requiring a high level of intervention present more often and cost more per presentation. If admitted they were more likely to have longer stays and were also more likely to be admitted to a psychiatric ward and have a longer stay in the ward.DiscussionThis study demonstrates a need for AOD interventions in the emergency department setting, both because it represents an opportunity for intervention in a population in which problems with substance use is highly prevalent, and because there is evidence that AOD imposes additional costs on the health system. [Butler K, Reeve R, Arora S, Viney R, Goodall S, van Gool K, Burns L. The hidden costs of drug and alcohol use in hospital emergency departments. Drug Alcohol Rev 2016;35:359–366]
OPTIMAL MONETARY POLICY AND IMPERFECT FINANCIAL MARKETS: A CASE FOR NEGATIVE NOMINAL INTEREST RATES?
Authors: Abo‐Zaid Salem , Garín Julio 
Published: July 2015

AbstractThis article studies optimal monetary policy in a model with credit frictions and money demand. We show that augmenting a standard New Keynesian model with money demand and financial frictions generates a mechanism that, in equilibrium, gives rise to optimal negative nominal interest rates. In addition, we find that the tighter credit markets are, the lower the optimal nominal policy interest rate and the more likely it is to be negative. Quantitatively, when credit constraints are binding, a standard calibration of the model generates an optimal nominal policy interest rate that is roughly −4% annually. (JEL E31, E41, E43, E44, E52, E58)
The N‐methyl‐D‐aspartate receptor's neglected subunit – GluN1 matters under normal and hyperbaric conditions
Authors: Bliznyuk Alice , Aviner Ben , Golan Hava , Hollmann Michael , Grossman Yoram 
Published: July 2015

AbstractProfessional deep‐water divers exposed to hyperbaric pressure (HP) above 1.1 MPa develop high‐pressure neurological syndrome, which is associated with central nervous system hyperexcitability. It was previously reported that HP augments N‐methyl‐D‐aspartate receptor (NMDAR) synaptic responses, increases neuronal excitability, and potentially causes irreversible neuronal damage. In addition, we have reported that HP (10.1 MPa) differentially affects ionic currents, measured by the two‐electrode voltage‐clamp technique, of eight specific NMDAR subtypes generated by the co‐expression of GluN1‐1a or GluN1‐1b with one of the four GluN2(A–D) subunits in Xenopus laevis oocytes. We now report that eight GluN1 splice variants, when co‐expressed with GluN2A, mediate different ionic currents at normal and HP (5.1 MPa). These data, in conjunction with our previous results, indicate that both GluN1 and GluN2 subunits play a critical role in determining NMDAR currents under normal and HP conditions. These data, given the differential spatial distribution of the different NMDAR subtypes in the central nervous system, may offer a partial explanation for the mechanism governing the complex signs and symptoms of high‐pressure neurological syndrome, and an explanation for the suspected long‐term HP health decrement due to repetitive deep dives by professional divers.