bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ten-year Followup of Infliximab Therapy in Rheumatoid Arthritis Patients with Severe, Longstanding Refractory Disease: A Cohort Study
Authors: De Keyser Filip , De Kock Joris , Leroi Hermine , Durez Patrick , Westhovens René ,   and the Infliximab EAP Study Group
Published: June 2014

Objective.Our study describes the 10-year followup data of the Belgian Expanded Access Program (EAP) for infliximab (IFX), which included patients with active rheumatoid arthritis who were refractory to methotrexate. The objectives of the study were to evaluate the continuation rate, reasons for discontinuation, and longterm disease control under IFX treatment, and to study baseline characteristics associated with longterm successful IFX therapy.Methods.Between February 2000 and September 2001, 511 patients were enrolled in the Belgian IFX EAP, and 507 effectively started IFX therapy. Previously reported data showed that 160 patients were still treated with IFX after 7 years of followup. We describe the therapy status, reasons for IFX discontinuation, and the level of disease activity of this subgroup after 10 years of followup. Baseline characteristics of the total EAP cohort were used to describe variables associated with longterm successful IFX treatment.Results.After 10 years of followup, 110 of the 507 patients (21.7%) were still receiving IFX treatment. In the 7-year to 10-year period, which is the focus of the current study, 16 patients were lost to followup and 34 patients discontinued IFX treatment, mainly because of loss of efficacy. Patients successfully treated with IFX for 10 years had lower baseline values for 28-joint Disease Activity Score (DAS28), patient pain scale, physician visual analog scale, and Health Assessment Questionnaire in comparison with the rest of the study cohort. The mean DAS28 level of the subgroup still taking IFX after 10 years was 2.55 ± 1.01.Conclusion.In the Belgian EAP, 21.7% of patients continued to receive maintenance IFX treatment after 10 years of followup. IFX provided good longterm disease control in these patients.
Ecological constraints and distribution of the primitive and enigmatic endemic Mexican butterflyBaronia brevicornis(Lepidoptera: Papilionidae)
Authors: Legal Luc , Dorado Oscar , Machkour-M’Rabet Salima , Leberger Roxanne , Albre Jérôme , Mariano Nestor A. , Gers Charles 
Published: June 2014

AbstractBaronia brevicornisSalvin (Lepidoptera: Papilionidae) is one of the most enigmatic butterflies in the world and possibly represents the most ancient lineage among the superfamily Papilionoidea. Its geographic distribution is remote from that of all its potential close relatives and many of its biological and ecological characteristics are unique among the suborder Rhopalocera. One of its particularities is that the occurrence plots of this species seem to be independent, each representing individual populations, despite the fact that the host plant:Acacia cochliacanthaHumboldt and Bonpland ex Willdenow (Fabaceae), is one of the most common Mexican Fabaceae species. Our results show that noB. brevicornispopulations occur if the host plant does not cover at least two-thirds of the locality. Even in the most favourable zones, the landscape occupancy of the butterfly does not exceed 2.5% of the available habitat even when its host plant covers 50% of the area. The average density of adults was 840 individuals/ha in favourable habitats, frequently on areas of around 3 ha, below of 1400 m. Using the BIOMOD2 package and the largest available set of abiotic conditions for Mexico implemented in the WorldClim database, we propose a revised potential distribution and discuss the results of our model with field occurrence data. Evolutionary and conservation issues are discussed in the light of our results.
In-well monitoring for Deepwater Wells - Operator's View
Authors: Patni Sandeep , Dria Dennis 
Published: June 2014

AbstractThe high cost of subsea intervention makes in-well monitoring its greatest value. Even if interventions are possible it may not be at optimal well condition with the traditional technology. There also will be SIMOPS and operation issues. Real time in-well monitoring can be done at full well rates to operate well at maximum safe rates and thus lead to higher recovery. Acquiring key reservoir productivity and continuity data early can decrease risk for subsequent well decisions and help in development decisions. In-well monitoring will provide flow rates by sand layer, provide gas breakthrough and water breakthrough information and pinpoint exact location. All this information to engineers can help in decreasing production deferment from these producing wells. In case of injectors, warm back data helps in identifying zones where maximum water is getting injected and may identify out of zone injection.However significant challenges remain in selection, qualification and deployment of these technologies in deepwater subsea wells. The paper will provide an operator's view point covering some of the key challenges below:All components must be rigorously qualified to meet the stringent safety and operational requirements. The subsea tree interface between the tree and tubing hanger and between the lower upper completion creates a significant technical challenge. While there are potential solutions, dispersed capability in supplier base creates an integration challenge.The scope is further challenged by implementing across diverse reservoirs, flow and production characterization, completion type and enormous integration across various product groups.There is no point deploying state of the art advanced sensing if the resulting data is not easily accessible and interpreted. Especially in the subsea environment where costs are high, the entire value chain (hardware, data management and interpretation) needs to be in place to bring value.Resolution, accuracy and sampling time are interrelated and we are not able to achieve all with the current technology at the desired depth and offset distances. For certain operation such as planned well shut-in, buildups and press temperature analysis we need higher sampling rate which are easily and remotely configurableOperator needs to overcome internal hurdles – various functional teams (wells, subsea, IT) have to work together; this requires significant effort in terms of working the interfaces, integration and ultimately moving towards standardization.In-well monitoring can improve quality of surveillance in subsea wells enabling low cost, non intrusive, well and reservoir surveillance provided the industry overcomes the technical challenges/gaps and improves the reliability of the system.
Development and Characterization of Smart Cement for Real Time Monitoring of Ultra-Deepwater Oil Well Cementing Applications
Authors: Vipulanandan C. , Krishnamoorti R. , Saravanan R. , Liu J. , Qu Q. , Narvaez G. , Hughes Baker , Richardson D. A. , Pappas J. M. 
Published: June 2014

AbstractFor a successful cementing operation, it is critical to determine the flowing of cement slurry between the casing and formation, depth of the circulation losses and fluid loss, setting of cement in place and performance of the cement after hardening. Recent case studies on cementing failures have clearly identified some of these issues that resulted in various types of delays in the cementing operations. At present there is no technology available to monitor cementing operations in real time from the time of placement through the borehole service life. Also, there is no reliable method to determine the length of the competent cement supporting the casing.In this study well cement was modified to have better sensing properties, smart cement, so that its behavior can be monitored at various stages of construction and during the service life of wells. A series of experiments evaluated well cement behavior with and without modifications in order to identify the most reliable sensing properties that can also be relatively easily monitored. During the initial setting the electrical resistivity changed with time based on the type and amount of additives used in the cement. During curing initial resistivity reduced by about 10 percent to reach a minimum resistance, and maximum change in resistance within the first 24 hours of curing varied from 50 to 300 percent depending on the additive. A new quantification concept has been developed to characterize cement curing based on electrical resistivity changes in the in the first 24 hours. When cement was modified with less than 0.1 percent of conductive additives, the piezoresistive behavior of the hardened smart cement was substantially improved without affecting the cement rheological and setting properties. For modified smart cement the resistivity change at peak stress was about 400 times higher than the change in the strain.
A study to correlate histopathology, biochemical marker and immunohistochemical expression of sex-steroid receptors in prostatic growth
Authors: Naskar Sukla , Kundu Soumya Kanti , Bhattacharyya Nirmal Kumar , Bhattacharyya Pranab Kumar , Kundu Anup Kumar 
Published: June 2014

AbstractProstate gland is a fibromusculoglandular structure situated at the neck of urinary bladder. So, enlargement or growth of prostate due to nodular hyperplasia (NHP) or prostatic intraepithelial neoplasia (PIN) or adenocarcinoma may give rise to bladder outlet obstruction. Malignant growth i.e., PIN or adenocarcinoma cases are associated with increased blood level of prostate-specific antigen (PSA) and increased expression of different sex-steroid receptors because the growth is dependent on the interactions of androgen, progesterone and estrogen. The aim of our study is to correlate the histopathology, PSA levels and expression of different sex-steroid receptors by immunohistochemistry in different prostatic growth lesions. Among the total 50 cases received, inclusive of transurethral resection of prostate (TURP), transrectal ultrasound-guided biopsy and radical prostatectomy, 34 cases were diagnosed as NHP, 4 cases as PIN and 12 cases as adenocarcinoma histopathologically. Serum PSA values above 10 ng/ml were seen in 2 cases of PIN and 11 cases of adenocarcinoma and none of NHP. Estrogen receptor (ER) () expressions were negative in all cases. Progesterone receptor (PR) expressions were strongly positive in 35% cases of both NHP and adenocarcinoma, whereas androgen receptor (AR) expressions were strong among all cases of adenocarcinoma and only in four cases of NHP. By observing these findings it can be suggested that antiandrogen and antiprogesterone therapy simultaneously will do better than antiandrogen alone in treating prostatic growth lesions.
Interobserver variation is a significant limitation in the diagnosis of Burkitt lymphoma
Authors: Rane Swapnil Ulhas , Shet Tanuja , Sridhar Epari , Bhele Sanica , Gaikwad Vaishali , Agale Shubhangi , Shinde Sweety , Prabhat Daksha , Fernandes Gwendolyn , Hastak Meenal , Tampi Chandralekha , Narurkar Swati , Patel Keyuri , Madiwale Chitra , Shah Ketki , Shah Laxmi , Sawaimoon Satyakam , Lad Purnima 
Published: June 2014

Abstract
Context: The pathology of classic Burkitt lymphoma (BL) remains a challenge despite being a well-defined entity, in view of the significant overlap with atypical BL and B-cell lymphoma intermediate between DLBL (diffuse large B cell lymphoma) and BL. They are difficult to be segregated in resource-limited setups which lack molecular testing facilities. This is further affected by interobserver variability and experience of the reporting pathologist. Aims: The aim of our study was to quantitate variability among a group of pathologists with an interest in lymphomas (albeit with variable levels of experience) and quantitate the benefit of joint discussions as a tool to increase accuracy and reduce interobserver variability of pathologists, in the diagnosis of BL in a resource-limited setup. Materials and Methods: A set of 25 non-Hodgkin lymphoma cases in which a diagnosis of BL was entertained were circulated to 14 participating pathologist within the Mumbai lymphoma study group. A proforma recorded the morphologic and immunohistochemical features perceived during the initial independent diagnosis followed by a consensus meeting for discussion on morphology and additional information pertinent to the case. Statistical analysis and Results: The concordance was poor for independent diagnosis among all the pathologists with kappa statistics (±SE) of 0.168 (±0.018). Expert lymphoma pathologists had the highest (albeit only fair) concordance (kappa = 0.373 ± 0.071) and general pathologists the lowest concordance (kappa = 0.138 ± 0.035). Concordance for morphological diagnosis was highest among expert lymphoma pathologists (kappa = 0.356 ± 0.127). Revision of diagnoses after consensus meeting was highest for B-cell lymphoma intermediate between DLB and BL. To conclude, interobserver variation is a significant problem in BL in the post WHO 2008 classification era. Experience with a larger number of cases and joint discussion exercises such as the one we conducted are needed as they represent a simple and effective way of improving diagnostic accuracy of pathologists working in a resource-limited setup.
A randomized study to compare sequential chemoradiotherapy with concurrent chemoradiotherapy for unresectable locally advanced esophageal cancer
Authors: Gupta Arunima , Roy Somnath , Majumdar Anup , Hazra Avijit , Mallik Chandrani 
Published: June 2014

Abstract
Background: Chemotherapy combined with radiotherapy can improve outcome in locally advanced esophageal cancer. Aim: This study aimed to compare efficacy and toxicity between concurrent chemoradiotherapy (CCRT) and sequential chemoradiotherapy (SCRT) in unresectable, locally advanced, esophageal squamous cell carcinoma (ESSC). Materials and Methods: Forty-one patients with unresectable, locally advanced ESCC were randomized into two arms. In the CCRT arm (Arm A), 17 patients received 50.4 Gy at 1.8 Gy per fraction over 5.6 weeks along with concurrent cisplatin (75 mg m -2 intravenously on day 1 and 5-fluorouracil (1000 mg m -2 continuous intravenous infusion on days 1-4 ; starting on the first day of irradiation and given after 28 days. In the SCRT arm (Arm B), 20 patients received two cycles of chemotherapy, using the same schedule, followed by radiotherapy fractionated in a similar manner. The endpoints were tumor response, acute and late toxicities, and disease-free survival. Results: With a median follow up of 12.5 months, the complete response rate was 82.4% in Arm A and 35% in Arm B (P = 0.003). Statistically significant differences in frequencies of acute skin toxicity (P = 0.016), gastrointestinal toxicity (P = 0.005) and late radiation pneumonitis (P = 0.002) were found, with greater in the CCRT arm. A modest but non-significant difference was observed in median time to recurrence among complete responders in the two arms (Arm A 13 months and Arm B 15.5 months, P = 0.167) and there was also no significant difference between the Kaplan Meier survival plots (P = 0.641) of disease-free survival. Conclusions: Compared to sequential chemoradiotherapy, concurrent chemoradiotherapy can significantly improve local control rate but with greater risk of adverse reactions.
Impact of dental considerations on the quality of life of oral cancer patients
Authors: Thanvi Jaishree , Bumb Dipika 
Published: June 2014

Abstract
Aim: To evaluate the significance of pre-treatment dental care in oral cancer patients and to assess its impact on the quality of life of these patients. Materials and Methods: The sample size included 50 oral cancer patients who were visiting to a palliative care unit at Jaipur. Assessment was based on thorough case history, complete dental examination. Quality of life was estimated by W.H.O quality of life questionnaire. Result: On analysis, patients of age group 50-59 avoided to prophylactic dental treatment before cancer treatment and therapy. Seventy-eight percent patients experienced worst quality of life after the treatment as a result of dental complications. Out of those 78%, only 2% of patients took preventive dental treatments before the cancer therapy. Conclusion: Dental negligence is still a major cause of worsening of post treatment quality of life of an individual. Therefore, the treating oncologist should always take these considerations seriously to provide quality treatment to the patient.
Posterior reversible encephalopathy syndrome in pediatric acute leukemia: Case series and literature review
Authors: Appachu M Appachu , Purohit Samit , Lakshmaiah K.C. , Aruna B.S. Kumari , Appaji L 
Published: June 2014

AbstractPosterior reversible encephalopathy syndrome (PRES) is a neurotoxic state coupled with a unique radio imaging appearance. We describe this rare, mostly reversible condition in five cases undergoing similar treatment under preset protocol (MCP-841) for acute lymphoblastic leukemia (ALL) at our centre. Hypertension is a well-known adverse effect of high-dose corticosteroid therapy primarily mediated by its effects on the mineralocorticoid receptor especially in pediatric population and we hypothesize that this may be the etiology of PRES in two of these patients.
Tongue trail to kidney
Authors: Khobragade Krunal Harishchandra , Bakshi Ganesh K. , Prakash Gagan , Menon Santosh 
Published: June 2014

AbstractRenal cell carcinoma (RCC) has the propensity to metastasize to any organ in the body. Tongue metastases from RCC is very rare with most of them being metachronous in nature. We present a rare case where patient presented with a tongue lesion leading to a diagnosis of RCC. Surgery is the preferred modality of treatment for tongue metastases.
Gefitinib-induced skin ulceration in metastatic adenocarcinoma lung
Authors: Sathyanarayanan Vishwanath , Lokesh Kadabur Nagendrappa , Channaviriappa Lakshmaiah Kuntejowdahalli , Jacob Linu Abraham 
Published: June 2014

AbstractWe report a case of gefitinib-induced skin ulceration in a 50-year-old female with metastatic adenocarcinoma of lung who developed this adverse effect 2 weeks following initiation of gefitinib at a dose of 250 mg/day. The ulcer improved with stopping gefitinib for 2 weeks and also addition of topical steroids and antibiotics. We are reporting this case to create awareness among treating oncologists of this adverse effect and also prompt interruption of therapy and topical steroids/antibiotics is useful to treat this adverse event.
Gestão do conhecimento para tomada de decisão: um estudo de caso na Empresa Júnior
Authors: Magalhães Thiago Gonçalves , Dalmau Marcos Baptista Lopez , Souza Irineu Manoel de 
Published: June 2014

O conhecimento é o recurso primordial para as organizações no processo de tomada de decisão nos dias atuais, dessa forma, a gestão do conhecimento é uma ferramenta de grande importância para a criação e a retenção do conhecimento nas organizações, essencial para subsidiar o processo decisório. Entretanto a grande maioria das empresas, especialmente as pequenas e médias, ainda não possuem um processo de gestão do conhecimento formalizado, mas possuem algumas práticas que também apoiam de forma positiva o processo decisório. A Ação Júnior Consultoria Socioeconômicas, empresa Júnior do Centro Sócio Econômico da UFSC não possui um processo de gestão do conhecimento estruturado, mas possui diversas práticas nas quais a diretoria executiva se subsidia para a tomada de decisão na empresa, dessa maneira o objetivo do trabalho foi averiguar como as praticas de gestão de conhecimento na empresa dão suporte para o processo decisório. A pesquisa se caracteriza como qualitativa, descritiva e aplicada. Foram realizadas entrevistas com os membros da diretoria executiva com o intuito de levantar as práticas de gestão do conhecimento e posteriormente entender como subsidiam o processo de tomada de decisão. Como resultado pode-se perceber que a empresa possui diversas práticas de gestão do conhecimento e que são de grande importância para no processo decisório, no entanto se faz necessário uma melhor estruturação, formalização e acompanhamento dessas práticas e no tratamento dos conhecimentos gerados pelas mesmas.
Genres as Species and Spaces:
Authors: Wells Susan 
Published: June 2014

ABSTRACTContemporary genre theory is dominated by metaphors of evolution and speciation; this article proposes alternate metaphors of spatiality and exchange. A spatial understanding of genre permits more productive interactions between literary and rhetorical genre theory. A reading of Robert Burton's The Anatomy of Melancholy as a multigenred text suggests some of the potentials of this approach.
Heidegger and the Aesthetics of Rhetoric
Authors: Reeves Joshua , Stoneman Ethan 
Published: June 2014

ABSTRACTThis article uses Heidegger's critique of the aesthetic tradition to reconsider the limits and potential of aesthetic rhetoric. Contextualizing rhetoric's so-called aesthetic turn within the German aesthetic tradition, we argue that aesthetic rhetoric remains constrained by aesthetics' traditional opposition to the rational and the true. This theoretical heritage has often prevented contemporary aesthetic rhetorical theory from considering the value of art beyond sense experience and ritualized cultural reproduction. We claim, however, that rhetoric can be artistic and at the same time project a community's evolving sense of political and social truth. Through an analysis of Simón Bolívar's Angostura Address, which in 1819 inaugurated a political rebirth of the Venezuelan republic, we demonstrate how the art of rhetoric can exhibit Heidegger's three senses of “aletheiaic” truth: the bestowing, grounding, and beginning of a political community.
Analýza vývoje vnímání národní identity německou CDU v letech 1990–2009
Authors: Vít Michal 
Published: June 2014

The paper aims to explain the development of the perception of national identity of the Christian Democratic Party (CDU), the strongest German political party in the past few decades. The paper focuses on election manifestos for the 1990, 1994, 1998, 2002, 2005, and 2009 elections. For this purpose, each manifesto is examined according to up to five analytical categories – such as values, nation, Europe, threats, and society. These categories explore the party’s perception in a wider context instead of focusing only on direct references to national identity. The analysed period was divided into three phases with an emphasis on the internal crisis between the years 1998 and 2002. The crisis influenced policy priorities; therefore the perceptions of elements belonging to national identity were changed in order i) to gain victory in the general elections in 2002 and 2005, and ii) to reflect properly the state of German society. Therefore, significant policy shifts were made. These policy changes show how the party successfully integrated societal demands and preferences over the past decade. Thank to this, the CDU incorporated both conservative and liberal elements. This is evident in the case of incorporating liberal elements such as homosexual partnerships while, at the same time, actively stressing the importance of defending national interests.
Des pratiques propices au vivre-ensemble avec des femmes immigrantes au sein d’organisations communautaires
Authors: Chamberland Manon , Le Bossé Yann 
Published: June 2014

Les obstacles récurrents rencontrés par des femmes immigrantes, notamment en ce qui concerne leur insertion socioprofessionnelle, ont plusieurs répercussions sur leurs conditions de vie et leur quotidien. Que font les intervenants qui les accompagnent dans leurs démarches ? Cet article présente quatre fondements sur lesquels reposent les pratiques d’intervenantes dans des organisations communautaires de Montréal, Bruxelles et Grenoble. Leurs pratiques rendent compte du développement de solidarités et de savoirs partagés permettant d’exercer un changement sur des obstacles rencontrés quotidiennement par des femmes immigrantes.