bluuebunny/crossref_metadata_2025_split huggingface dataset:
Climate Resilient Cities: A Review of Blue-Green Solutions Worldwide
Authors: Przestrzelska Kornelia , Wartalska Katarzyna , Rosińska Weronika , Jurasz Jakub , Kaźmierczak Bartosz 
Published: August 2024

AbstractProgressing climate change significantly affects the quality of life in cities. The related changes in the rainfall structure lead to an increased frequency of extreme hydrological phenomena such as droughts and floods. The increasing intensity of rainfall is a particular threat to urbanised areas, where due to the high degree of area sealing, an increase in runoff volumes and peak flow rate is observed. Storm water drainage systems are often not adapted to accommodate increased rainwater flows, which leads to the so-called urban floods. On the other hand, prolonged periods without precipitation may, in turn, lead to periodic water shortages. Cities must implement a climate change adaptation strategy. One of the solutions for rational rainwater management is the implementation of Blue-Green Infrastructure. These facilities are a modern solution supporting the sewage networks operation, water retention, and improving the quality of life in cities. The article presents the literature review on the current state of knowledge about Blue-Green Infrastructure and the implementation stage of these solutions in the world. Solutions that are newly introduced, not necessarily newly invented, in many places around the world are described. The literature review was limited to the period 2018–2023 to indicate the most modern and up-to-date strategies.
Measuring Positive Health using the My Positive Health (MPH) and Individual Recovery Outcomes Counter (I.ROC) Dialogue Tools: A Panel Study on Measurement Properties in a Representative General Dutch Population
Authors: van Druten Vera P. , Metz Margot J. , Mathijssen Jolanda J. P. , van de Mheen Dike , van Vliet Marja , Rudd Bridey , de Vries Esther , Nahar van - Venrooij Lenny M. W. 
Published: August 2024

AbstractWe aimed to investigate whether the dialogue tools My Positive Health (MPH) and Individual Recovery Outcomes Counter (I.ROC) tools were useful for quantitively measuring the positive health construct for monitoring and scientific purposes as well. An observational cross-sectional study was conducted in a representative general Dutch population (the LISS panel) to investigate factor structures and internal consistency from the 42-items MPH and 12-items I.ROC. After randomly splitting the dataset, principal component analysis (PCA) and confirmatory factor analysis (CFA) were applied. Pearson and Spearman correlation coefficient between both tools’ total scores were calculated. 2,457 participants completed the questionnaires. A six-factor structure was extracted for MPH (PH42) and a two-factor structure for I.ROC (I.ROC12). Explained variances were 68.1% and 56.1%, respectively. CFA resulted in good fit indices. Cronbach’s alphas were between 0.74 to 0.97 (PH42) and 0.73 to 0.87 (I.ROC12). Pearson correlation between the total scores was 0.8 and Spearman correlation was 0.77. Both PH42 and I.ROC12 are useful to quantitatively measure positive health aspects which can be summarised in sum scores. The dimensions found in this study and the corresponding item division differed from the dimensions of the original dialogue tools. Further research is recommended focussing on item reduction for PH42, factor structure of I.ROC, assessment of construct validity (in a general population) and response scales in more depth.
Television Viewing from Young Adulthood to Middle Age and Premature Cardiovascular Disease Events: A Prospective Cohort Study
Authors: Nagata Jason M. , Vittinghoff Eric , Cheng Chloe M. , Dooley Erin E. , Lin Feng , Rana Jamal S. , Sidney Stephen , Lewis Cora E. , Pettee Gabriel Kelley 
Published: August 2024

Abstract
Background
Previous literature has explored the relationship between television viewing and cardiovascular disease (CVD) in adults; however, there remains a paucity of longitudinal data describing how young adult television viewing relates to premature CVD events.

Objective
To ascertain the relationship between level and annualized changes in television viewing from young adulthood to middle age and the incidence of premature CVD events before age 60.

Design
The Coronary Artery Risk Development in Young Adults (CARDIA) study, a prospective community-based cohort with over 30 years of follow-up (1985–present).

Participants
Black and White men and women who were 18–30 years old at baseline (1985–1986).

Main Measures
Independent variables: Individualized television viewing trajectories were developed using linear mixed models. Dependent variables: Fatal and nonfatal coronary heart disease (CHD), heart failure, and stroke outcomes were analyzed separately and as a combined CVD event outcome.

Key Results
Among 4318 included participants, every 1-h increase in daily hours of television viewing at age 23 was associated with higher odds of incident CHD (adjusted odds ratio [AOR] 1.26, 95% confidence interval [CI] 1.06–1.49) and incident CVD events (AOR 1.16, 95% CI 1.03–1.32). Each additional hour of daily television viewing annually was associated with higher annual odds of CHD incidence (AOR 1.55, 95% CI 1.06–2.25), stroke incidence (AOR 1.58, 95% CI 1.02–2.46), and CVD incidence (AOR 1.32, 95% CI 1.03–1.69). Race and sex modified the association between television viewing level at age 23 and CHD, heart failure, and stroke, with White men most consistently having significant associations.

Conclusions
In this prospective cohort study, greater television viewing in young adulthood and annual increases in television viewing across midlife were associated with incident premature CVD events, particularly CHD. Young adulthood as well as behaviors across midlife may be important periods to promote healthy television viewing behavior patterns.
Between Crisis and Revival: Withdrawal Threats, State Exits, and Institutional Change of Regional International Organizations
Authors: Panke Diana , Grundsfeld Lukas , Tverskoi Pawel 
Published: August 2024

AbstractSince 1945, there have been more than 120 instances of states threatening to withdraw from international organizations with regional membership criteria (RIOs) and over 50 cases in which states in fact left RIOs. Recent examples include withdrawal threats by Qatar toward the Gulf Cooperation Council and Brazil toward MERCOSUR, as well as the actual exits of the United Kingdom from the European Union (EU) and of Burkina Faso, Mali, and Niger from the Economic Community of West African States. Withdrawal threats and exits represent shocks with potentially significant implications for RIOs and their integration projects. While existing research has focused on the future of EU integration after Brexit, this paper is the first to analyze the effects of threats to leave and the realization thereof on RIOs and regional integration from a broader comparative perspective. RIOs can respond to exit-related challenges through institutional change, which can take the form of institutional strengthening or weakening. Having conducted a series of explorative qualitative case studies, we find that while (1) the extent of problem pressure induced through exit-related challenges influences institutional change, (2) the materialization and directionality of these changes also depends on other factors, such as external windows of opportunity and the distribution of power and preferences within the RIO. Furthermore, (3) institutional change often takes the form of institutional strengthening, indicating the general resilience of international organizations in the context of exit-related challenges.
Zur Situation erziehungswissenschaftlicher Forschung an Hochschulen und außeruniversitären Forschungseinrichtungen
Authors: Schmidt-Hertha Bernhard , Tippelt Rudolf 
Published: August 2024

ZusammenfassungErziehungswissenschaftliche Forschung hat sich seit ihren Anfängen deutlich ausdifferenziert und gerade in den letzten Jahrzehnten eine starke empirische und methodische Erweiterung erfahren. Heute ist erziehungswissenschaftliche Forschung gekennzeichnet durch die breite Bearbeitung unterschiedlicher Ebenen von Lern- und Bildungsprozessen, durch interdisziplinäre Kooperationen und die Parallelität einer Vielfalt von Forschungszugängen und Paradigmen. Diese Vielfalt spiegelt sich auch in den Quellen von Forschungsmitteln sowie in den Publikationspraxen wider. Sichtbar werden disziplinäre Spezifika besonders im Vergleich mit anderen Sozial- und Kulturwissenschaften. Dabei sieht sich die Erziehungswissenschaft in besonderer Weise mit dem Anspruch konfrontiert, praxisrelevante Ergebnisse zu liefern. Der Beitrag greift aktuelle Daten und Diskurse zu den genannten Punkten auf und entwickelt daraus ein Gesamtbild, das die Spezifität erziehungswissenschaftlicher Forschung und ihre Potenziale herausarbeitet.
Genome-wide identification and expression analysis of the GST gene family of Betula platyphylla
Authors: Hu Xiaoqing , Zheng Tong , Chen Wenjie , Duan Huilei , Yuan Zhongjia , An Jiaqian , Zhang Huihui , Liu Xuemei 
Published: August 2024

AbstractGlutathione-S-transferase (GST, EC2.5.1.18) multifunctional protease is important for detoxification, defense against biotic and abiotic stresses, and secondary metabolic material transport for plant growth and development. In this study, 71 members of the BpGST family were identified from the entire Betula platyphylla Suk. genome. Most of the members encode proteins with amino acid lengths ranging from 101 to 875 and were localized to the cytoplasm by a prediction. BpGSTs can be divided into seven subfamilies, with a majority of birch U and F subfamily members according to gene structure, conserved motifs and evolutionary analysis. GST family genes showed collinearity with 22 genes in Oryza sativa L., and three genes in Arabidopsis thaliana; promoter cis-acting elements predicted that the GST gene family is functional in growth, hormone regulation, and abiotic stress response. Most members of the F subfamily of GST (BpGSTFs) were expressed in roots, stems, leaves, and petioles, with the most expression observed in leaves. On the basis of the expression profiles of F subfamily genes (BpGSTF1 to BpGSTF13) during salt, mannitol and ABA stress, BpGSTF proteins seem to have multiple functions depending on the type of abiotic stress; for instance, BpGSTs may function at different times during abiotic stress. This study enhances understanding of the GST gene family and provides a basis for further exploration of their function in birch.
Role of different oils and cooking materials on chemical compounds and antioxidant properties of garlic
Authors: Zor Melek , Karakutuk Isa Arslan , Sengul Memnune , Topdas Elif Feyza , Yilmaz Bilal 
Published: August 2024

AbstractThis study determined the effects of cooking Taşköprü garlic, which is grown with a geographical indication in Turkiye, in three cooking materials (unbleached parchment paper (UP), bleached parchment paper (BP), and oven bag (OB)) and four vegetable oils (sunflower oil (SO), hazelnut oil (HO), corn oil (CO), and olive oil (OO)) on total phenolic content, antioxidant activity, phenolic compound profile, and chemical compound profile. The effects of cooking material (CM) and oil type (OT) on garlic samples’ TPC were found to be insignificant (p > 0.05). However, cooking material (CM) and oil type (OT) impacted antioxidant activity. According to cooking material, statistically, the highest antioxidant activity with the DPPH method was identified in garlic cooked using UP and BP, while the highest antioxidant activity with the ABTS method was found in garlic cooked with BP and OB. The garlic samples roasted with the mentioned oils and cooking materials were analyzed by LC-MS/MS in terms of thirty-five phenolic compounds. However, only five of these compounds (quinic acid, fumaric acid, hesperidin, ferulic acid, and rosmarinic acid) were detected in the samples. The chemical components of the cooked garlic samples primarily consist of terpenoids (β–sitosterol and squalene). The use of cooking material affected the amount of squalene compound in all garlic samples cooked with olive oil. Among these samples, the lowest squalene rate (52.11%) was found in only roasted garlic. In addition, according to GC-MS results, we can say that the use of hazelnut oil and unbleached parchment paper in the roasting process has a protective effect on the cis-vaccenic acid compound, which is known to show anticancer properties.
Graphical Abstract
Long-term effects of COVID-19 pandemic on physical activity and eating behaviour of the Italian population: a longitudinal study
Authors: Bifolco Giuseppe , Cardinali Ludovica , Mocini Edoardo , Duradoni Mirko , Baldari Carlo , Ciampi Marina , Migliaccio Silvia , Cianferotti Luisella 
Published: August 2024

Abstract
Background
Restrictive measures due to the Covid-19 pandemic strongly impacted lifestyle and daily behaviour. The purpose of this longitudinal retrospective study was to investigate short-term and long-term effects of Covid-19 pandemic on physical activity and eating habits of the Italian population investigating three time periods: pre-, during- and post-lockdown.

Methods
A sample of 2773 adults recruited through social media provided data by an online survey administered from July to October 2023. Participants completed the International Physical Activity Questionnaire–Short Form (IPAQ-SF), the Mediterranean Diet Adherence Screener (MEDAS) and provided information about eating habits, socio-demographic and anthropometric characteristics.

Results
There was a significant increase (p < 0.001) in mean BMI from pre-pandemic period (24.53 ± 5.34 Kg/m2) to post-pandemic period (25.22 ± 6.0 Kg/m2). Physical Activity significantly decreased during the pandemic period compared to the pre-pandemic period (χ² = 271.97; p < 0.001; φ = 0.31) with an increase in inactive subjects from 25.7% to 52.8%. In the post pandemic period, there was an increase in the level of Physical Activity compared to the pandemic period (χ² = 413.61; p < 0.001; φ = 0.39) with a reduction of inactive subjects from 52.8% to 25.6%. Adherence to Mediterranean Diet score significantly (p < 0.001) increase from pre-pandemic (7.18 ± 1.58) to during-pandemic (7.29 ± 1.69) and post-pandemic (7.75 ± 1.63) periods with significant differences emerged in the consumption of single MEDAS items during the pandemic period by different BMI classes. Consumption of seasonal fruit and vegetables, water intake, the preparation/consumption of traditional or local dishes and the time dedicated for dinner and lunch significant increase (p < 0.001) during pandemic.

Conclusions
The Covid-19 pandemic changed people’s lifestyles, but in different ways for Physical Activity and diet. During the pandemic there was a negative effect for PA that decreased while the time spent sitting increased. This seems to be a temporary effect as, after the end of the phase of mandatory restrictions, it returns to the original level. The lockdown period improved the quality of the Italian population’s eating habits, with an increase in adherence to the Mediterranean diet even after the end of the pandemic showing a rediscovery of traditional dishes, increase in consumption of seasonal products, greater preference for local products and more time spent preparing meals.
Molecular Characterization and Expression of Lactoferrin Receptor (LfR) in Different Regions of the Brain Responding to Lactoferrin Intervention
Authors: Wang Siqi , Zhang Nai , Jiang Bowen , Lönnerdal Bo , Chen Yue , Wang Bing 
Published: August 2024

Abstract
Lactoferrin (LF), an iron-binding glycoprotein rich in human milk, promotes neurodevelopment and cognition, but whether it acts through the LF receptor (LfR) and its expression profile in the brain remains unknown. We characterized 972 bp of piglet brain LfR cDNA and found LfR mRNA was expressed all brain regions being highest in the frontal lobe, followed by parietal lobe, brainstem, occipital lobe, cingulate gyrus, subventricular zone, olfactory bulb, hippocampus, amygdala, cerebellum, and thalamus. LfR mRNA and protein in different regions of the brain responded to low (155 mg/kg/day) and high (285 mg/kg/day) LF supplementation of piglets from postnatal days 3 to 38. By postnatal day 39, the low LF diet significantly increased LfR protein expression in the occipital lobe compared to controls, but not the high LF diet. LfR protein in the subventricular zone of the high LF group was 42% and 38% higher than that of the low LF group and controls, respectively. There was a trend for a dose–response relationship between LF intervention and LfR protein expression only in the prefrontal and parietal lobes. LF supplementation significantly improved piglet working memory for a difficult task, which was positively correlated with LfR protein in the prefrontal, parietal, and occipital lobes, but no dose response. Brain LfR responds to dietary LF supplementation, a mechanism by which LF can promote learning and working memory through its receptor. LfR is expressed in the whole brain, and its expression level is anatomic region specific.
Streamflow forecasting with deep learning models: A side-by-side comparison in Northwest Spain
Authors: Farfán-Durán Juan F. , Cea Luis 
Published: August 2024

AbstractAccurate hourly streamflow prediction is crucial for managing water resources, particularly in smaller basins with short response times. This study evaluates six deep learning (DL) models, including Long Short-Term Memory (LSTM), Gated Recurrent Unit (GRU), Convolutional Neural Network (CNN), and their hybrids (CNN-LSTM, CNN-GRU, CNN-Recurrent Neural Network (RNN)), across two basins in Northwest Spain over a ten-year period. Findings reveal that GRU models excel, achieving Nash-Sutcliffe Efficiency (NSE) scores of approximately 0.96 and 0.98 for the Groba and Anllóns catchments, respectively, at 1-hour lead times. Hybrid models did not enhance performance, which declines at longer lead times due to basin-specific characteristics such as area and slope, particularly in smaller basins where NSE dropped from 0.969 to 0.24. The inclusion of future rainfall data in the input sequences has improved the results, especially for longer lead times from 0.24 to 0.70 in the Groba basin and from 0.81 to 0.92 in the Anllóns basin for a 12-hour lead time. This research provides a foundation for future exploration of DL in streamflow forecasting, in which other data sources and model structures can be utilized.
Tazemetostat for relapsed/refractory B-cell non-Hodgkin lymphoma with EZH2 mutation in Japan: 3-year follow-up for a phase II study
Authors: Izutsu Koji , Ando Kiyoshi , Nishikori Momoko , Shibayama Hirohiko , Goto Hideki , Kuroda Junya , Kato Koji , Imaizumi Yoshitaka , Nosaka Kisato , Sakai Rika , Abe Maho , Hojo Seiichiro , Nakanishi Tadashi , Rai Shinya 
Published: August 2024

AbstractPreviously, we reported the efficacy and safety of tazemetostat in Japanese patients with relapsed/refractory follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL) harboring the EZH2 mutation in a multicenter, open-label, phase II study. Here, we present a follow-up analysis of tazemetostat at a long-term median follow-up of 35.0 months. Twenty patients were enrolled: 17 in the FL cohort and three in the DLBCL cohort. In the FL cohort, the objective response rate was 70.6%, consistent with the primary analysis, and the median progression-free survival (PFS) was not reached. The 24-month and 36-month PFS rates were 72.1% (95% confidence interval [CI] 41.5%–88.6%) and 64.1% (95% CI 33.7%–83.4%), respectively. The median duration of treatment was 30.2 months. After the primary analysis at a median follow-up of 12.9 months, grade 1–2 urinary tract infection, peripheral motor neuropathy, and hypogammaglobulinemia newly emerged, but the incidence of adverse events (AEs) did not increase notably during this follow-up period. No unexpected grade ≥ 3 treatment-related AEs were reported. Long-term oral monotherapy with tazemetostat showed favorable efficacy and safety profiles, indicating that it may be a useful third-line or later treatment option for patients with relapsed/refractory FL harboring the EZH2 mutation. Trial registration: ClinicalTrials.gov: NCT03456726.
A Qualitative Study on Adolescents’ Perceptions and Understandings of Flourishing in the Western Cape, South Africa
Authors: Witten Heidi , Savahl Shazly , Adams Sabirah 
Published: August 2024

AbstractAdolescence is a transitional period characterised by puberty, physical growth, and the capacity to complete life tasks. During this period, adolescents are faced with various challenges in completing various life tasks. Flourishing is defined as a state in which an individual functions optimally, and has a good level of well-being in all aspects of their life. Previous studies on adolescent flourishing have focused on measuring flourishing quantitatively, which suggests a need for further research that qualitatively explores adolescent flourishing. In this study we use the conceptualisation of flourishing that encompasses hedonia and eudaimonia. It is crucial to position adolescents at the core of research endeavours, to gain insight into the unique factors, values, and goals that contribute to their flourishing. The overall aim of the study is to explore adolescents’ understandings and perceptions of flourishing in the Western Cape, South Africa. Semi-structured individual interviews were conducted to gain a comprehensive understanding of adolescents’ perceptions and understanding of flourishing. The interviews were analysed using Braun and Clarke’s theoretical thematic analysis. We found two overarching thematic categories: 1) Understanding flourishing and 2) Factors that promote flourishing. The study findings emphasise the significance of balance in different aspects of life such as mental health, self-reflection, and self-expression to support adolescents in developing their own sense of flourishing and to understand their own experiences. The central role of relationships as a support structure for adolescents was found to be significant as the participants were able to identify what is needed through these relationships, which could promote their own flourishing. Future empirical research should endeavour to include both hedonic and eudaimonic traditions in exploring adolescent flourishing.
Advancing the Science of Intervention Development in School Mental Health: A Commentary on this Special Issue
Authors: Evans Steven W. , Bakhtiari Azadeh 
Published: August 2024

AbstractThis commentary examines the critical importance of intervention development and adaptation research in school mental health, as highlighted by the studies in this special issue. We discuss two primary reasons for advancing this field: increasing the use of evidence-based practices and enhancing intervention benefits by adapting to unique needs. The paper emphasizes the significance of identifying meaningful moderators of intervention response and proposes adopting an intersectionality perspective to better understand the complex factors influencing intervention effectiveness. We review several studies from the special issue that exemplify innovative approaches to intervention adaptation, including peer-supported interventions, culturally responsive programs for specific populations, and adaptations for rural school settings. The commentary also explores the distinction between adapting intervention “packaging” versus mechanisms of action, and highlights the value of community partner involvement in the development process. We argue that by carefully considering moderators of intervention response and embracing an intersectionality framework, researchers can develop effective interventions for diverse youth populations. The paper concludes by discussing future directions for intervention development research in school mental health, emphasizing the need for continued innovation to address the complex and varied needs of students in educational settings.