bluuebunny/crossref_metadata_2025_split huggingface dataset:
Goodbye to accelerated phase of chronic myeloid leukaemia
Authors: Jiang Qian , Yang Sen , Zhang Xiao-shuai , Gale Robert , Huang Xiaojun 
Published: June 2024

Abstract

Whether there is really a distinct accelerated phase (AP) at diagnosis in chronic myeloid leukemia (CML) in the context of tyrosine kinase-inhibitor (TKI)-therapy and whether co-variates identified as characterizing AP are simply adverse co-variates for outcomes, we studied 2,122 consecutive subjects in chronic phase (CP, n = 1,837) or AP (n = 285) according to the European LeukemiaNet (ELN) classification. AP subjects with increased basophils only had similar transformation-free survival (TFS) and survival compared with CP subjects in ELTS intermediate-risk. AP subjects with increased blasts only had worse TFS but similar survival compared with CP subjects in the ELTS high-risk; AP subjects with decreased platelets only, similar TFS but worse survival. Proportions of CP and AP subjects meeting the 2020 ELN TKI-response milestones were similar. However, worse outcomes were only seen in AP subjects failing to meet ELN milestones. Findings were similar using the 2022 International Consensus Classification (ICC) criteria replacing decreased platelets with additional cytogenetic abnormalities. Our data support the 2022 WHO classification of CML eliminating AP. We suggest adding a very high-risk cohort to the ELTS score including people with increased blasts or decreased platelets and dividing CML into 2 phases: CP and acute phase.
A Simple Method for Bandwidth Enhancement of Dual-Polarized Dipole Antenna Printed on Dielectric Materials
Authors: Li Ronglin , Hu Xiang , Cui Yuehui , He Chiyu 
Published: June 2024

Abstract

In this paper, a simple method for enhancing the bandwidth of a dual-polarized dipole antenna printed on dielectric substrate is presented. By introducing parasitic elements above the crossed dual-polarized dipoles, the bandwidth of the antenna has been increased from 45% to 74% for return loss>15 dB. The parasitic elements can be printed with the dipoles and the integrated balun on the same substrate. The bandwidth enhanced dual-polarized antenna keeps a simple structure, which is easy for manufacturing. The bandwidth enhanced or further enhanced dual-polarized printed-dipole antenna features stable radiation patterns with high isolation, which may find wide applications for 2G/3G/4G/5G base stations.
Comparative biomechanical analysis of pedicle screws versus cortical bone trajectory fixation in the treatment of ankylosing spondylitis
Authors: Zhang Le , Kang Zhijie , Shi Guopeng , Jin Feng , Zhang Yunfeng , Zhang Honglai , Wang Zhenfeng , Wang Haiyan , Zhang Kai , Li Xiaohe 
Published: June 2024

Abstract

Background
Ankylosing spondylitis (AS) is an inflammatory rheumatic disease. Patients with spinal deformities are typically treated with long-segment pedicle screw (PS) internal fixation after bone resection. However, issues with the operation, such as fracture and screw loosening or pulling out, might arise.
Methods
This study explore the biomechanical responses to PS and cortical bone trajectory (CBT) fixation. Using finite element analysis (FEA) on reconstructed preoperative and postoperative spine models under six conditions, it predicted stiffness, range of motion (ROM), and von Mises stress, comparing PS and CBT fixation effects.
Results
Stiffness was greater in the PS than CBT, while the PS performed better than the CBT under bending stiffness, except for the PS under extension conditions. In flexion, extension, and lateral bending, the PS sustained higher stress than CBT, while in axial rotation, CBT experienced greater stress than PS, with stress concentration at the level of bone resection. Furthermore, during spinal dynamics, calcified ligaments bore substantial stress. Biomechanically, PS demonstrated superior strength during flexion, extension, and lateral bending conditions. Whereas, under conditions of left and right rotation, the CBT technique provided better biomechanical strength.
Conclusion
Compared to PS, the current CBT technique was sufficiently effective in maintaining spinal fusion stability after bone resection for AS.
HDI-STARR-seq: Condition-specific enhancer discovery in mouse liver in vivo
Authors: Chang Ting-Ya , Waxman David J. 
Published: June 2024

Abstract

Background
STARR-seq and other massively-parallel reporter assays are widely used to discover functional enhancers in transfected cell models, which can be confounded by plasmid vector-induced type-I interferon immune responses and lack the multicellular environment and endogenous chromatin state of complex mammalian tissues.
Results
Here, we describe HDI-STARR-seq, which combines STARR-seq plasmid library delivery to the liver, by hydrodynamic tail vein injection (HDI), with reporter RNA transcriptional initiation driven by a minimal Albumin promoter, which we show is essential for mouse liver STARR-seq enhancer activity assayed 7 days after HDI. Importantly, little or no vector-induced innate type-I interferon responses were observed. Comparisons of HDI-STARR-seq activity between male and female mouse livers and in livers from males treated with an activating ligand of the transcription factor CAR (Nr1i3) identified many condition-dependent enhancers linked to condition-specific gene expression. Further, thousands of active liver enhancers were identified using a high complexity STARR-seq library comprised of ~ 50,000 genomic regions released by DNase-I digestion of mouse liver nuclei. When compared to stringently inactive library sequences, the active enhancer sequences identified were highly enriched for liver open chromatin regions with activating histone marks (H3K27ac, H3K4me1, H3K4me3), were significantly closer to gene transcriptional start sites, and were significantly depleted of repressive (H3K27me3, H3K9me3) and transcribed region histone marks (H3K36me3).
Conclusions
HDI-STARR-seq offers substantial improvements over current methodologies for large scale, functional profiling of enhancers, including condition-dependent enhancers, in liver tissue in vivo, and can be adapted to characterize enhancer activities in a variety of species and tissues by selecting suitable tissue- and species-specific promoter sequences.
From Cell to Circuit: Investigating Functional Topological Changes in iPSC-derived Neuronal Networks in Major Depressive Disorder
Authors: Wetzel Christian , Issa Rahaf , Wein Simon , Milenkovic Vladimir , Rupprecht Rainer , Schwarzbach Jens 
Published: June 2024

Abstract

The functional organization of brain networks maintains a delicate equilibrium between segregation and integration where it facilitates local neural communication together with effective global integration of information across network’s components. While numerous whole-brain imaging studies have linked alterations in functional topology to major depressive disorder (MDD), our comprehension of how these changes manifest at the cellular level remains limited. Here, we explored whether neuronal networks derived from induced pluripotent stem cells (hiPSCs) of nine depressed patients display a distinct functional topology compared to those of matched controls. Spontaneous activity of the derived neuronal networks was captured using calcium imaging, and graph theory analysis was applied to assess functional topology. We computed the graph metrics clustering coefficient and global efficiency to quantify respective network segregation and integration attributes. We also measured the average node degree to assess group differences in the overall number of connections. We observed a decrease in clustering coefficient and average node degree in MDD-derived neural networks compared to those of controls. Global efficiency also exhibited a decreasing trend in patient-derived networks across varying thresholds and network sizes. Together, our findings reveal diminished segregation properties and a reduced number of nodal connections in MDD-derived neural networks, suggesting a predisposition for a less efficient functional topology in depression already at the microscale. This work marks the first attempt to explore microscale alterations in functional topology of human-derived neural networks in MDD and highlights the power of iPSC technology in providing a human cellular model to better understand disease mechanisms.
Enhanced removal of 1,2-dichloroethane by nanoscale calcium peroxide activation with Fe(III) coupled with different iron sulfides
Authors: Zhao Xuanran , Xu Yuanze , Zhu Xueqiang , Cao Enwei , Wang Wei , Lyu Shuguang 
Published: June 2024

ABSTRACT
Fe(II) is of great importance in iron-based advanced oxidation processes. However, traditional methods to maintain Fe(II) concentration, such as the addition of chelating agents or reducing agents, may lead to an increase in chemical oxygen demand of secondary pollution. Therefore, in this study, iron sulfides, namely ferrous sulfide (FeS), pyrite (FeS2), and sulfidated nanoscale zero-valent iron (S-nZVI), were applied for not only the regeneration of Fe(II) but also the direct dissolution of Fe(II). Nanoscale calcium peroxide (nCaO2) was synthesized and used as the oxidant. The removal of 1,2-dichloroethane (1,2-DCA) were significantly promoted from 8.8 to 98.2, 79.2, and 80.8% with the aid of FeS, FeS2, and S-nZVI within 180 min, respectively. The dominant reactive oxygen species were demonstrated and their steady-state concentrations were quantified. Besides, the dechlorination of 1,2-DCA reached 90.4, 69.5, and 83.9% in nCaO2/Fe(III) systems coupled with FeS, FeS2, and S-nZVI, respectively. All three systems had high tolerance to the complex water conditions, of which FeS-enhanced nCaO2/Fe(III) system displayed the best performance, which could be recommended to put into practice for the remediation of 1,2-DCA contaminated groundwater.
Organophosphorus Synthesis beyond P-Cl Bond: The Development of Shelf-stable Reagents for [RP] Transfer
Authors: Romanenko Vadim D. 
Published: June 2024

:
The direct chlorine-free incorporation of P1 units into organic molecules has very
important synthetical value owing to environmental considerations and the prospect of accessing
unique compounds with fascinating structures and useful properties. This selective
survey presents a panorama of phosphorus species that are synthetic equivalents of free
singlet phosphinidenes [R-P] and highlights the state-of-art of the [RP]-transfer reactions
with emphasis on the synthesis of molecular architectures difficult to reach using traditional
methods. Among stabilized phosphinidene precursors capable of RP-transfer are terminal
transition-metal phosphinidene and phosphinidenoid complexes, dibenzo-7λ3-
phosphinobornadienes, phosphinidene-phosphoranes, inversely polarized phosphaalkenes,
phosphaketenes, intramolecularly base-stabilized phosphinidenes, (cyclo)polyphosphines
and diphosphenes.
Design of Optimized Solid Lipid Nanoparticles of Montelukast Sodium and Assessment of Oral Bioavailability in Experimental Model
Authors: Dangre Pankaj , Wankhede Paresh , Moravkar Kailas , Kalaskar Mohan , Mundada Atish , Chalikwar Shailesh 
Published: June 2024

Introduction:
The objective of the reported work was to develop Montelukast sodium
(MS) solid lipid nanoparticles (MS-SLNs) to ameliorate its oral bio-absorption. Herein, the highpressure
homogenization (HPH) principle was utilized for the fabrication of MS-SLNs.

Method:
The study encompasses a 23 full factorial statistical design approach where mean particle
size (Y1) and percent entrapment efficiency (Y2) were screened as dependent variables while, the
concentration of lipid (X1), surfactant (X2), and co-surfactant (X3) were screened as independent
variables. The investigation of MS-SLNs by DSC and XRD studies unveiled the molecular
dispersion of MS into the SLNs while TEM study showed the smooth surface of developed MSSLNs.
The optimized MS-SLNs exhibited mean particle size (MPS) = 115.5 ± 1.27 nm,
polydispersity index (PDI) = 0.256 ± 0.04, zeta potential (ζ) = -21.9 ± 0.32 mV and entrapment
efficiency (EE) = 90.97 ± 1.12 %. The In vivo pharmacokinetic study performed in Albino Wistar
rats revealed 2.87-fold increments in oral bioavailability.

Results:
The accelerated stability studies of optimized formulation showed good physical and
chemical stability. The shelf life estimated for the developed MS-SLN was found to be 22.38
months.

Conclusion:
At the outset, the developed MS-SLNs formulation showed a significant increment
in oral bioavailability and also exhibited excellent stability in exaggerated storage conditions.
Participation of Lens Proteins and miRs in Traumatic and Inheritance
Cataract: A Review on Diagnostic and Therapeutic Approaches for
Cataract Management
Authors: Panda Siva Prasad , Pachauri Navneet , Kesharwani Adarsh , Prasanth DSNBK , Singh Vikrant 
Published: June 2024

Abstract:
Traumatic and inherited cataract spiking blindness is caused by accumulated deposition of mutant eye lens protein or lens microarchitecture alteration. A traumatic cataract is a
clouding of the eye’s natural lens that occurs as a result of physical trauma to the eye. This trauma can be caused by various incidents such as blunt force injury, penetration by a foreign object,
or a significant impact on the eye area. Inheritance cataracts or hereditary cataracts are cataracts
that are genetically inherited from one or both parents. Complications following cataract surgery
encompass various adverse outcomes such as inflammation, infection, bleeding, swelling, drooping eyelid, glaucoma, secondary cataracts, and complete loss of vision. The main purpose of the
review is to highlight common pathophysiology associated with traumatic and inherited cataracts. Also, the review discusses diagnosis and treatment strategies for such cataract types by
targeting their key pathological hallmarks. γD-crystallin plays a crucial role in maintaining the
optical properties of the lens during the life span of an individual. Carbamazepine, Resveratrol,
and Myricetin (CRM) are effectively bound at the γD-crystallin binding site and thereby could
minimize misfolding and aggregation of γD-crystallin. miR-202, miR-193b, miR-135a, miR365, and miR-376a had the highest levels of abundance in the aqueous humor of individuals
diagnosed with cataracts. The validation of these miRs will provide more insights into their
functional roles and may be used for diagnostic purposes. The effective CRM combination as a
multidrug formulation may postpone both traumatic and inherited cataracts and protect the eye
from blindness.
Pt(IV) Prodrug Photoactivation: A Promising Strategy for Cancer Therapy
Authors: Tang Lingkai , Luo Yafei , Luo Wenqin , Sun Guangzhou , Jiang Yu , Zhang Zhigang , Yue Xinru , Li Siyao , Liang Li , Liu Wei , Hu Jianping 
Published: June 2024

:
Platinum (II) drugs, including cisplatin, carboplatin, and oxaliplatin, have achieved significant
clinical success in cancer treatment. However, their clinical application has been greatly
hindered by various adverse factors, such as non-specific activation and drug resistance. Compared
with Pt(II) drugs, the axial ligands within Pt(IV) compounds can improve the pharmacokinetic
properties, selectivity, and biological activity, implementing alternative cytotoxic mechanisms
beyond DNA cross-linking and partially overcoming drug resistance. The controlled conversion
of Pt(IV) prodrugs into Pt(II) agents at the tumor site has been extensively explored internationally.
In this review, Pt(IV) prodrug modification strategies are first summarized, and the development
of the predominant external and internal photosensitizers is listed. Finally, three representative
photoreduction mechanisms and strategies for developing corresponding Pt(IV) prodrugs
are discussed. This work provides constructive instruction for the subsequent molecular design of
Pt(IV) prodrugs.
Recent Biochemical Advances in Antitubercular Drugs: Challenges and Future
Authors: Jain Akanksha , Kumar Rajesh , Mothsra Poonam , Sharma Atul Kumar , Singh Anil Kumar , Kumar Yogesh 
Published: June 2024

:
Tuberculosis (TB) is one of the leading causes of death world-wide after AIDS. It infects
around one-third of global population and approximately two million people die annually
from this disease because it is a very contagious disease spread by Mycobacterium tuberculosis.
The increasing number of drug-resistant strains and the failure of conventional treatments against
this strain are the challenges of the coming decades. New therapeutic techniques aim to confirm
cure without deterioration, to reduce deaths, contagions and the formation of drug-resistant
strains. A plethora of new diagnostic tests are available to diagnose the active tuberculosis, screen
latent M. tuberculosis infection, and to identify drug-resistant strains of M. tuberculosis. When effective
prevention strategies do not prevail, high rates of early case detection and successive cures
to control TB emergence would not be possible. In this review, we discussed the structural features
of M. tuberculosis, Multi drug resistance tuberculosis (MDR-TB), extremely drug-resistant
tuberculosis (XDR-TB), the mechanism of M. tuberculosis infection, the mode of action of first
and second-line antitubercular drugs, the mechanism of resistance to the existing drugs, compounds
in preclinical and clinical trial and drugs presently available for the treatment of tuberculosis.
Moreover, the new diagnostic techniques to detect M. Tuberculosis are also discussed in this
review.
A Comprehensive View on Narrative Aspects of Cosmeceutical Agents
Intended for Skin Care
Authors: Pal Rashmi Saxena , Pal Yogendra , Chaitanya MVNL , Dogra Sakshi Sharma , Srivasatava Preeti 
Published: June 2024

Abstract:
Cosmetics may have "pharmaceutical therapeutic benefits" but not always "biological therapeutic rewards.,” Products for skin care that combine cosmetics and pharmaceuticals are known as
Cosmeceuticals. Cosmeceuticals are applied topically like cosmetics, but they also contain substances
that affect the biological functions of the skin. Cosmetics make people seem better, but they do so by
giving their skin the nutrition it needs to stay healthy. Cosmeceutical skincare has specific ingredients
to correct particular skin concerns or conditions. For example, they have high percentages of salicylic
acid and niacinamide to correct oily to acne-prone skin. A skincare expert has access to pharmaceutical-grade items that can be utilized to customize each client's at-home or face regimen. This study
aims toprovide an up-to-dateanalysis of cutting-edge natural bio-actives that not only improve skin
health but also shield it from a range of dangerous agents, such as UV radiation and free radicals.
Recent Advances in the Transition Metal (Cu, Ni, Fe, Co) Catalyzed OrganicReaction: A Mini-Review
Authors: Kamboj Monika , Yadav Nikita , Bajpai Sangeeta 
Published: June 2024

:
Transition metals have a useful and significant role in catalysis. They are considered essential chemical tools in various organic transformations.
Transition Metal catalysts are extensively used in the research laboratory and industrial/manufacturing processes. Indeed, it is hard to find a
complex synthetic reaction or an industrial process that does not, at some stage, require a metal catalyst. They have a paramount impact on organic
transformations and have been considered the core part of catalysis in chemistry. This article reports the catalyst reaction by transition metals (Cu,
Ni, Fe, and Co).
A Review of Traditional Anthelmintic Approaches: Exploring Medicinal Plants and Polyherbal Formulations for Effective and Safe Gastrointestinal Parasite Treatment
Authors: Pannu Arzoo , Kumari Parina 
Published: June 2024

:
Gastrointestinal parasites have become the most common reason for infection in humans, affecting many people in the world. Helminthic infections pose a large threat to public
health in developing countries. The most common parasites of helminths in humans are whipworms(Trichuristrichiura), roundworms(Ascarislumbricoides), tapeworms(Taenia solium), and
hookworms (Ancylostoma duodenale and Necator americanus). In the current scenario, synthetic
medicines are found to be effective in curing the infection but these medicines produce side-effects that impair the effectiveness of the treatment. Fortunately, in the traditional system of medicines various medicinal plants have been mentioned for their anthelmintic activities, which are
relatively free from side effects and are used by ethnic groups worldwide. In the 21st century, an
ideal anthelmintic agent should be cost-effective, provide a high percentage of cure, have a broad
spectrum of action, and free from toxicity to the host. However, none of the modern marketed
medicines fulfill these requirements. Therefore, in this view, several researchers have undertaken
various in vivo and in vitro studies to scrutinize folklore medicinal plants for their proclaimed
anthelmintic activity. In thisreview, we have summarized some scientifically approved polyherbal
formulations and Indian medicinal plants documented for anthelmintic activity, which can be further studied to achieve novel herbal lead molecules from them by isolating their principal compounds.
A Developed Model Based on Machine Learning Algorithms for Phishing Website Detection
Authors: Abdel-Jaber Hussein , Al Bazar Hussein , Naser Muawya 
Published: June 2024

Introduction:
Users are accessing websites for many purposes, such as obtaining information
about a particular topic, buying items, accessing their accounts, etc. Cybercriminals use
phishing websites to attain the sensitive information of the users, like usernames and passwords,
credit card details, etc. Detecting phishing websites helps in protecting the information and the
money of people. Machine learning algorithms can be applied to detect phishing websites.

Methods:
In this paper, a model based on various machine learning algorithms is developed to
detect phishing websites. The machine learning algorithms used in this model are Decision
Tree, Random Forest, Extra Trees, K-Nearest Neighbors, Multilayer Perceptron and Support
Vector Machine. The dataset of phishing websites is taken from the Kaggle website. The algorithms
mentioned above of the developed model are compared together to identify which
algorithm has better classification results.

Results:
The extra trees algorithm offers the best results for accuracy, precision, and F1-
Score. This paper also compares the developed model with a previous model that uses the
same dataset and relies upon decision tree, random forest, and support vector machine to determine
which model has better classification report results. The developed model, depending
on the Decision Tree and SVM, offers better classification results than those of the previous
models. The developed model is compared with another preceding model relying upon
Decision Tree and Random Forest algorithms to determine which model generates better results
for accuracy, precision, recall/sensitivity, and F1-Score.

Conclusion:
The developed model, depending on the Decision Tree, presents better results
for accuracy, recall, and F1-Score than the results of accuracy, sensitivity, and F1-Score for
the preceding model based on the Decision Tree.