bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and Privacy in Immersive Extended Reality: An Analysis and Policy Recommendations
Authors: Hine Emmie , Rezende Isadora Neroni , Roberts Huw , Wong David , Taddeo Mariarosaria , Floridi Luciano 
Published: July 2024

AbstractExtended reality (XR) technologies have experienced cycles of development—“summers” and “winters”—for decades, but their overall trajectory is one of increasing uptake. In recent years, immersive extended reality (IXR) applications, a kind of XR that encompasses immersive virtual reality (VR) and augmented reality (AR) environments, have become especially prevalent. The European Union (EU) is exploring regulating this type of technology, and this article seeks to support this endeavor. It outlines safety and privacy harms associated with IXR, analyzes to what extent the existing EU framework for digital governance—including the General Data Protection Regulation, Product Safety Legislation, ePrivacy Directive, Digital Markets Act, Digital Services Act, and AI Act—addresses these harms, and offers some recommendations to EU legislators on how to fill regulatory gaps and improve current approaches to the governance of IXR.
Digital Health Empowerment, Autonomy, and the Capability Approach: Reply to de Proost and Grey
Authors: Nickel Philip J. , Loosman Iris , Frank Lily , Vinnikova Anna 
Published: July 2024

AbstractDe Proost & Grey criticize Nickel et al.’s article “Justice and empowerment through digital health: ethical challenges and opportunities,” arguing that it should have embraced relational autonomy and capability approaches. We distinguish two variants of this critique, one saying that a view of digital health empowerment should welcome these approaches, and one saying that a view of digital health empowerment should essentially be defined in terms of these approaches. We are somewhat open to the first variant: relational autonomy and the capability approach are promising ways of spelling out the ethical values behind digital health empowerment, even if they are not completely unproblematic and uncontroversial. However, there are reasons to reject the second variant. A view that leaves the exact normative commitments of digital health empowerment open is persuasive to a wider audience, and more amenable to different constructs of autonomy, capability, and empowerment across disciplines.
Engineering biomaterials by inkjet printing of hydrogels with functional particulates
Authors: Cheng Cih , Williamson Eric J , Chiu George T.-C. , Han Bumsoo 
Published: July 2024

AbstractHydrogels with particulates, including proteins, drugs, nanoparticles, and cells, enable the development of new and innovative biomaterials. Precise control of the spatial distribution of these particulates is crucial to produce advanced biomaterials. Thus, there is a high demand for manufacturing methods for particle-laden hydrogels. In this context, 3D printing of hydrogels is emerging as a promising method to create numerous innovative biomaterials. Among the 3D printing methods, inkjet printing, so-called drop-on-demand (DOD) printing, stands out for its ability to construct biomaterials with superior spatial resolutions. However, its printing processes are still designed by trial and error due to a limited understanding of the ink behavior during the printing processes. This review discusses the current understanding of transport processes and hydrogel behaviors during inkjet printing for particulate-laden hydrogels. Specifically, we review the transport processes of water and particulates within hydrogel during ink formulation, jetting, and curing. Additionally, we examine current inkjet printing applications in fabricating engineered tissues, drug delivery devices, and advanced bioelectronics components. Finally, the challenges and opportunities for next-generation inkjet printing are also discussed.
Graphical Abstract
Association between serum 25-hydroxyvitamin D concentrations and respiratory tract infections requiring hospital admission: analysis of ethnic groups from the UK Biobank cohort
Authors: Bournot A. R , Hart K. H , Givens D. I. , Lovegrove J. A , Bartlett D. B , Lanham-New S. A , Darling A. L 
Published: July 2024

Vitamin D status has been found to be inversely associated with risk of respiratory tract infections (RTIs)(1). It varies by ethnicity, with several ethnic minority groups in the United Kingdom (UK) reported to be at a higher risk of vitamin D deficiency (serum 25-hydroxyvitamin D (25(OH)D) concentrations <25 nmol/L) compared to their white counterparts(2, 3). However, the relationship between serum 25(OH)D concentrations and incidence of RTIs by ethnicity in the UK remains unclear. This study aimed to investigate the association between serum 25(OH)D concentrations and likelihood of hospitalisation for RTI in UK ethnic groups.A nested, case-control study was conducted using data from UK Biobank, which has data for 500k adults for serum 25(OH)D and hospital episodes from linked records. Binary logistic regression models were used to explore the association between serum 25(OH)D concentrations and likelihood of RTIs overall, and by ethnicity.Of the 36,772 participants included in the analysis, 12,638 (34%) were white Caucasian, 10,311 (28%) Asian, 7,138 (19%) black, 4,034 (11%) other, and 2,651 (7%) of mixed ethnicity. In fully adjusted models, compared to participants with a serum 25(OH)D concentration <15 nmol/L (severe deficiency), those with 25-49 nmol/L, 50-74 nmol/L, and ≥75 nmol/L were found to have statistically significantly lower odds of RTI hospitalisation, with odds ratios (ORs) of 0.53 (95% CI: 0.37, 0.75), 0.61 (95% CI: 0.40, 0.92) and 0.54 (95% CI: 0.30, 0.97), respectively. In the subgroup analysis, ethnic minorities and white individuals with vitamin D deficiency (<25 nmol/L) were more likely to be hospitalised with RTI compared to those that were not deficient, with ORs of 1.36 (95% CI: 1.02, 1.81) and 2.03 (95% CI: 1.30, 3.17), respectively. This association was not statistically significant within ethnic minority subgroups when analysed separately.Serum 25(OH)D concentrations above 25 nmol/L are associated with lower likelihood of RTI hospitalisation among UK adults. This finding was noted across white and ethnic minority groups, although ethnic minorities with vitamin D deficiency had a lower likelihood of RTIs compared to white individuals. Further studies are warranted to validate these findings and explore the mechanisms underlying the association between vitamin D status and RTIs in different ethnic groups.AcknowledgementsThis project was conducted using the UK Biobank resource under project 15168.
Assessing Radar Attenuation in RIMFAX Soundings at the Jezero Western Fan Front, Mars
Authors: Eide Sigurd , Casademont Titus M. , Shoemaker Emileigh S. , Brovoll Sverre , Berger Tor , Dypvik Henning , Hamran Svein‐Erik 
Published: July 2024

AbstractEstimates of radar attenuation in the shallow Martian subsurface are retrieved from RIMFAX soundings along the Perseverance rover traverse. Specifically, analyzed data is from the Hawksbill Gap area during the rover's first drives onto the Jezero Western Fan Front. The centroid frequency‐shift method is employed to quantify attenuation in terms of the constant‐Q approximation. Results are then compared with the amplitude decay method, which—in order to calculate attenuation—requires propagation velocities retrieved from radargram analysis. By verifying that results from two separate analyses are consistent, we ensure that quantified radar properties are well constrained. First estimate of constant‐Q is 78.8 ± 11.6. For a subsurface propagation velocity of 0.113 m/ns, that equals an attenuation of −2.1 ± 0.4 dB/m at the RIMFAX 675 MHz center frequency. Results are consistent with dry sedimentary rocks, and are distinguishable from the magmatic lithologies on Jezero Crater Floor.
The complexity of tracking stegosaurs and their gregarious behavior
Authors: Castanera Diego , Mampel Luis , Cobos Alberto 
Published: July 2024

AbstractStegosaur tracks were unknown until the identification of Deltapodus more than 20 years ago. Currently, the Iberian Peninsula, especially Teruel Province, is one of the areas globally with the most occurrences of these tracks. However, their identification, based on the global record, is problematic due to their similarities with sauropod tracks. A review of the largest number of analyzed Deltapodus tracks globally, including the holotype of D. ibericus and a description of new occurrences, has been carried out. Our research shows substantial morphological variations, but all the studied tracks can be considered D. ibericus based on the manus morphology and the morphometric data. These variations are related to substrate differences and/or different dynamic foot postures (possibly ontogenetically related) during locomotion, as evidenced by changes within the same trackway. We provide detailed comparisons via 3D modeling with sauropod tracks, and our data show that they generally have proportionally longer manus and wider pes because of the differences in the metapodial bones. The scarcity of stegosaur trackways in the fossil record has prevented the identification of gregarious behavior in this group of herbivorous dinosaurs. Two of the studied tracksites show evidence of this behavior, being the only examples among stegosaurs described thus far in the fossil record.
Clinical characteristics of chronic obstructive pulmonary disease patients with superoptimal peak inspiratory flow rate
Authors: Kim Taeyun , Moon Ji-Yong , Park Hye Yun , Kim Youlim , Rhee Chin Kook , Lee Chang Youl , Park Joo Hun , Park Yong Bum , Russell Richard , Yoo Kwang Ha , Ra Seung Won 
Published: July 2024

AbstractCharacteristics of chronic obstructive pulmonary disease (COPD) patients with superoptimal peak inspiratory flow rates (PIFR) has not been thoroughly investigated. This study aimed to compare the characteristics between COPD patients with superoptimal PIFR and those with optimal and sub-optimal PIFR. PIFR was measured using In-Check DIAL G16 and categorized into sub-optimal (PIFR lower than that required by the patient’s device), optimal, and superoptimal (peak PIFR ≥ 90 L/min). Considering COPD patients with sub-optimal PIFR as the reference group, analyses were performed to identify PIFR-related factors. Subgroup analysis was performed according to the forced expiratory volume in 1 s (FEV1) % of the predicted value (%pred). Among 444 post-bronchodilator-confirmed COPD patients from seven tertiary hospitals in South Korea, 98, 223, and 123 were classified into the sub-optimal, optimal, and superoptimal PIFR groups, respectively. The superoptimal PIFR group were younger, had an increased proportion of males, a higher body mass index, lowest number of comorbidities and less frequent exacerbation in the previous year, as well as the highest forced vital capacity %pred. The adjusted odds ratio for frequent exacerbation in the previous year was lower in the superoptimal PIFR group than in the sub-optimal PIFR group and was more pronounced in patients with an FEV1%pred of < 70%. COPD patients with superoptimal PIFR have clinical characteristics different from those patients with the sub-optimal and optimal PIFR. Having a high inspiratory flow may be a favorable trait in COPD.
3D Gravity and magnetic inversion modelling for geothermal assessment and temperature modelling in the central eastern desert and Red Sea, Egypt
Authors: Gaber Gaber M. , Saleh Salah , Kotb Adel 
Published: July 2024

AbstractThe Central Eastern Desert and Red Sea region have emerged as a significant area of interest for geothermal energy exploration, owing to their unique geological characteristics and active tectonic activity. This research aims to enhance our understanding of the region's geothermal potential through a comprehensive analysis of gravity and magnetic data. By utilizing a 3D gravity inversion model, a detailed examination of subsurface structures and density variations was conducted. Similarly, a 3D magnetic inversion model was employed to investigate subsurface magnetic properties. Integration result from the Pygimli library ensured robustness and accuracy in the inversion results. Furthermore, a temperature model was developed using the WINTERC-G model and inversion techniques, shedding light on the thermal structure and potential anomalies in the study area. The analysis of the Bouguer gravity map, 3D gravity inversion model, and magnetic data inversion yielded significant findings. The Red Sea exhibited higher gravity values compared to the onshore Eastern Desert, attributed to the presence of a thinner and denser oceanic crust as opposed to the less dense continental crust in the Eastern Desert. The 3D gravity inversion model revealed distinct variations in density, particularly high-density zones near the surface of the Red Sea, indicating underlying geological structures and processes. Conversely, density gradually decreased with depth along the onshore line, potentially influenced by a higher concentration of crustal fractures. The magnetic data inversion technique provided additional insights, highlighting areas with demagnetized materials, indicative of elevated temperatures. These findings were consistent with the correlation between high-density areas and low magnetic susceptibility values, reinforcing the proposition of increased heat transfer from the Red Sea. Comparative analysis of temperature profiles further confirmed the presence of elevated temperatures in promising zones, emphasizing the geothermal potential associated with heat transfer from the Red Sea.This research contributes to the understanding of the geothermal resources in the Central Eastern Desert and Red Sea region. The results from gravity and magnetic data inversions, combined with temperature profiles, provide valuable information for future geothermal exploration and utilization efforts. The findings underscore the importance of geothermal energy in achieving sustainability and contribute to the global discourse on renewable energy sources.
Dietary inflammatory index could increase the risk of sarcopenia in patients with chronic kidney disease
Authors: Mansouri Fatemeh , Jafari Fatemeh , Ranjbar Sara , Souni Fateme , Jahromi Shahrokh Ezzatzadegan , Shateri Zainab , Babajafari Siavash , Nouri Mehran 
Published: July 2024

AbstractUsing a system that incorporates a variety of food items rather than focusing on individual components can aid in assessing the inflammatory effects of a diet on disease outcomes such as chronic kidney disease (CKD). Therefore, we decided to investigate the association between dietary inflammatory index (DII) and the risk of protein–energy wasting (PEW) and sarcopenia in patients with CKD. In this cross-sectional study, 109 patients with CKD were selected from two clinics in Shiraz, Iran. The intake of individuals’ diets was recorded using a validated 168-item food frequency questionnaire. Additionally, Asian Working Group for Sarcopenia (AWGS) guidelines were utilized to evaluate muscles’ strength, mass, and function. Also, four International Society of Renal Nutrition and Metabolism (ISRNM) criteria (body mass index, intake of protein, albumin, and urine creatinine) were used to diagnose PEW. Logistic regression was used to assess the association between DII and sarcopenia as well as PEW. The results showed that the intake of saturated fatty acids, trans fatty acids, niacin, beta-carotene, and vitamin C was significantly different between lower and higher DII groups. In the univariate model, higher odds of sarcopenia was observed by each unit increase in DII (odds ratio (OR) = 1.379, 95% confidence interval (CI): 1.042–1.824) and age (OR = 1.073, 95% CI: 1.017–1.132). Additionally, in the multivariate model, the association between DII and age with odds of sarcopenia remained significant (DII: OR = 1.379, 95% CI: 1.030–1.846 and age: OR = 1.063, 95% CI: 1.007–1.121). The current study suggests the possible role of pro-inflammatory foods in worsening muscle health, specifically sarcopenia, in CKD patients. Future longitudinal studies may reveal the causative nature of these correlations.
Vestibular hair cells are more prone to damage by excessive acceleration insult in the mouse with KCNQ4 dysfunction
Authors: Hong Hansol , Koo Eun Ji , Park Yesai , Song Gabae , Joo Sun Young , Kim Jung Ah , Gee Heon Yung , Jung Jinsei , Park Kangyoon , Han Gyu Cheol , Choie Jae Young , Kim Sung Huhn 
Published: July 2024

AbstractKCNQ4 is a voltage-gated K+ channel was reported to distribute over the basolateral surface of type 1 vestibular hair cell and/or inner surface of calyx and heminode of the vestibular nerve connected to the type 1 vestibular hair cells of the inner ear. However, the precise localization of KCNQ4 is still controversial and little is known about the vestibular phenotypes caused by KCNQ4 dysfunction or the specific role of KCNQ4 in the vestibular organs. To investigate the role of KCNQ4 in the vestibular organ, 6-g hypergravity stimulation for 24 h, which represents excessive mechanical stimulation of the sensory epithelium, was applied to p.W277S Kcnq4 transgenic mice. KCNQ4 was detected on the inner surface of calyx of the vestibular afferent in transmission electron microscope images with immunogold labelling. Vestibular function decrease was more severe in the Kcnq4p.W277S/p.W277S mice than in the Kcnq4+/+ and Kcnq4+/p.W277S mice after the stimulation. The vestibular function loss was resulted from the loss of type 1 vestibular hair cells, which was possibly caused by increased depolarization duration. Retigabine, a KCNQ activator, prevented hypergravity-induced vestibular dysfunction and hair cell loss. Patients with KCNQ4 mutations also showed abnormal clinical vestibular function tests. These findings suggest that KCNQ4 plays an essential role in calyx and afferent of type 1 vestibular hair cell preserving vestibular function against excessive mechanical stimulation.
Evaluation of EMLA cream with microneedle patches in palatal anesthesia in children: a randomized controlled clinical trial
Authors: Babakurd Farah M. , Azzawi Shadi K. , Alkhouli Muaaz , Al-Nerabieah Zuhair 
Published: July 2024

AbstractPalatal injections are considered to be one of the most painful dental procedures. As a result, it was important to find alternatives to this painful injection to improve children's cooperation. The dental literature mentioned using EMLA cream as a possible alternative to conventional injections, but its anesthetic effect was debated. Therefore, it was valuable to research the impact of microneedle patches to enhance the effectiveness of this cream. The purpose of this randomized controlled clinical trial was to compare the effectiveness of different methods of anesthesia and pain levels in children aged 7–11 years. The study compared the use of EMLA cream, EMLA with microneedles, and conventional palatal injections. A total of 90 children were randomly assigned to three groups: Group 1 received conventional palatal anesthesia (control), Group 2 received EMLA cream only, and Group 3 received EMLA with microneedles. Pain levels were assessed using the FLACC and Wong-Baker scales at three different time points: T1(during anesthesia), T2(on palatal probing), and T3(during extraction). The FLACC scale revealed a significant difference in pain between groups only at T1 (P value = 0.000). It was found that the conventional palatal injection group had a higher pain level than the EMLA cream-only group and the group using microneedle patches with EMLA cream (P value = 0.000). However, the other groups did not show significant differences in pain levels during the anesthesia (P value  = 1.00). Similarly, the Wong-Baker scale also demonstrated a statistically significant difference in pain between groups only at T1 (P value  = 0.000). It was found that the conventional palatal injection group had a higher pain level than the EMLA cream-only group and the group using microneedle patches with EMLA cream (P value  = 0.000). However, the other groups did not show significant differences in pain levels during the anesthesia (P value  = 0.091). The study concludes that both EMLA cream alone and EMLA with microneedles can be used as an alternative to conventional palatal anesthesia for children.
Normative data of the Italian Famous Face Test
Authors: Ventura Martina , Caffò Alessandro Oronzo , Manippa Valerio , Rivolta Davide 
Published: July 2024

AbstractThe faces we see in daily life exist on a continuum of familiarity, ranging from personally familiar to famous to unfamiliar faces. Thus, when assessing face recognition abilities, adequate evaluation measures should be employed to discriminate between each of these processes and their relative impairments. We here developed the Italian Famous Face Test (IT-FFT), a novel assessment tool for famous face recognition in typical and clinical populations. Normative data on a large sample (N = 436) of Italian individuals were collected, assessing both familiarity (d′) and recognition accuracy. Furthermore, this study explored whether individuals possess insights into their overall face recognition skills by correlating the Prosopagnosia Index-20 (PI-20) with the IT-FFT; a negative correlation between these measures suggests that people have a moderate insight into their face recognition skills. Overall, our study provides the first online-based Italian test for famous faces (IT-FFT), a test that could be used alongside other standard tests of face recognition because it complements them by evaluating real-world face familiarity, providing a more comprehensive assessment of face recognition abilities. Testing different aspects of face recognition is crucial for understanding both typical and atypical face recognition.
High prevalence of m.1555A > G in patients with hearing loss in the Baikal Lake region of Russia as a result of founder effect
Authors: Borisova Tuyara V. , Cherdonova Aleksandra M. , Pshennikova Vera G. , Teryutin Fedor M. , Morozov Igor V. , Bondar Alexander A. , Baturina Olga A. , Kabilov Marsel R. , Romanov Georgii P. , Solovyev Aisen V. , Fedorova Sardana A. , Barashkov Nikolay A. 
Published: July 2024

AbstractMitochondrial forms account approximately 1–2% of all nonsyndromic cases of hearing loss (HL). One of the most common causative variants of mtDNA is the m.1555A > G variant of the MT-RNR1 gene (OMIM 561000). Currently the detection of the m.1555A > G variant of the MT-RNR1 gene is not included in all research protocols. In this study this variant was screened among 165 patients with HL from the Republic of Buryatia, located in the Baikal Lake region of Russia. In our study, the total contribution of the m.1555A > G variant to the etiology of HL was 12.7% (21/165), while the update global prevalence of this variant is 1.8% (863/47,328). The m.1555A > G variant was notably more prevalent in Buryat (20.2%) than in Russian patients (1.3%). Mitogenome analysis in 14 unrelated Buryat families carrying the m.1555A > G variant revealed a predominant lineage: in 13 families, a cluster affiliated with sub-haplogroup A5b (92.9%) was identified, while one family had the D5a2a1 lineage (7.1%). In a Russian family with the m.1555A > G variant the lineage affiliated with sub-haplogroup F1a1d was found. Considering that more than 90% of Buryat families with the m.1555A > G variant belong to the single maternal lineage cluster we conclude that high prevalence of this variant in patients with HL in the Baikal Lake region can be attributed to a founder effect.