bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cystic local recurrence of renal cell carcinoma after laparoscopic radical nephrectomy in a hemodialysis patient
Authors: Ito Kazuyo , Takagi Toshio , Kondo Tsunenori , Yoshida Kazuhiko , Iizuka Junpei , Kobayashi Hirohito , Tomita Eri , Hashimoto Yasunobu , Tanabe Kazunari 
Published: August 2013

AbstractAlthough local recurrence of renal cell carcinoma after laparoscopic radical nephrectomy is sometimes reported, cystic local recurrence of renal cell carcinoma has rarely been reported. We report the case of a 59‐year‐old man with hemodialysis who developed cystic local recurrence of renal cell carcinoma accompanied by acquired cystic disease of the kidney in the retroperitoneal space after laparoscopic radical nephrectomy. A cystic tumor of 5.1 cm in diameter occurred in the left retroperitoneal space 15 months after left laparoscopic radical nephrectomy, and enlarged to 7.2 cm in diameter with enhanced mass along the wall of the cyst 36 months after surgery. The cystic tumor was removed and showed local recurrence of renal cell carcinoma on pathological examination.
Can I get a retweet please? Health research recruitment and the Twittersphere
Authors: O'Connor Anita , Jackson Leigh , Goldsmith Lesley , Skirton Heather 
Published: August 2013

AbstractAimTo evaluate the social networking site Twitter™ as a vehicle for recruitment in online health research and to examine how the Twitter community would share information: the focus of our study was the antenatal experience of mothers of advanced maternal age.BackgroundOne result of growth in worldwide Internet and mobile phone usage is the increased ability to source health information online and to use social media sites including Facebook and Twitter. Although social media have been used in previous health research, there is a lack of literature on the use of Twitter in health research.DesignA cross‐sectional survey.MethodWe report a novel recruitment method via a social networking site between May and August 2012. Through a Twitter account, we tweeted and requested other Twitter users to retweet our invitation to be involved in the study. Tweets contained a unique URL directing participants to an online survey hosted on the Survey Monkey™ website.FindingsOver 11 weeks, 749 original tweets were posted by the researcher. A total of 529 mothers accessed the survey as a result of 359 researcher tweets and subsequent retweets that were seen by Twitter users. The survey was fully completed by 299 (56·5%) participants.ConclusionTwitter is a cost‐effective means of recruitment, enabling engagement with potentially difficult‐to‐reach populations, providing participants with transparency, anonymity and a more accessible method by which to participate in health research.
Restoring drinking water acceptance following a waterborne disease outbreak: the role of trust, risk perception, and communication
Authors: Bratanova Boyka , Morrison Greg , Fife‐Schaw Chris , Chenoweth Jonathan , Mangold Mikael 
Published: August 2013

AbstractAlthough research shows that acceptance, trust, and risk perception are often related, little is known about the underlying patterns of causality among the three constructs. In the context of a waterborne disease outbreak, we explored via zero‐order/partial correlation analysis whether acceptance predicts both trust and risk perception (associationist model), or whether trust influences risk perception and acceptance (causal chain model). The results supported the causal chain model suggesting a causal role for trust. A subsequent path analysis confirmed that the effect of trust on acceptance is fully mediated by risk perception. It also revealed that trust is positively predicted by prior institutional trust and communication with the public. Implications of the findings for response strategies to contamination events are discussed.
The work–family interface among school psychologists and related school personnel: a test of role conflict and expansionist theories
Authors: Brown Theresa J. , Sumner Kenneth E. 
Published: August 2013

AbstractThe purpose was to test of the utility of role conflict and expansionist theories in explaining the work–family interface using psychometrically sound instruments. Participants (n = 74) responded to measures of work–family conflict, work‐related stress, and role quality. In support of the expansionist theory, results indicated that the quality of the life roles was a better predictor of both work–family conflict and work‐related stress than was the number of life roles. For both, results indicated that as quality of the work role increased, work–family conflict and work‐related stress decreased. The implications for the research on the work–family life interface and attracting and retaining the most qualified school psychologists are discussed.
Genetic background of claw disorders in the course of lactation and their relationships with type traits
Authors: Gernand E. , Döhne D.A. , König S. 
Published: August 2013

SummaryRandom regression threshold animal models were applied to binary longitudinal claw disorder data for studying genetic parameters of all claw disorders (ACD), as well as to claw disorders divided into different categories: non‐purulent claw disorders (NPCD), purulent claw disorders (PCD), dermatitis digitalis (DD), sole ulcer (SU), phlegmona (PH), laminitis (LAM) and interdigital hyperplasia (IH) in the course of lactation. Claw disorder data were obtained from 26 651 Holstein cows kept in 15 large‐scale contract herds in the region of Thuringia over a period of 5 years from 2007 to 2012. If a cow had one or more entries of the same disorder, for example, sole ulcer, within an interval of 30 days, she was scored with a ‘1’, and otherwise, she received a score of ‘0’ for healthy. Heritabilities for the same disorder were relatively stable between DIM 50 and DIM 300, but they tended to increase in early and late lactation. Highest heritabilities in the range from 0.20 to 0.34 were estimated for IH, and lowest heritabilities were realized for LAM (~ 0.05). Genetic correlations for same traits between different DIMs were high for adjacent test days, but close to zero for distant test days. The relationship between the sire EBVs for claw disorders and official sire EBVs for the type traits ‘foot angle’ was slightly antagonistic with correlation coefficients in the range from 0.05 (DD) to 0.33 (PH). Correlations between lactation EBVs for hock quality, rear leg rear view and the feet and leg index with EBVs for claw disorders were slightly favourable and ranged between −0.01 (rear leg rear view correlated with SU) and −0.43 (hock quality correlated with PH). Regarding daily EBVs for claw disorders, the strongest correlation coefficient was of value −0.46 (LAM early in lactation correlated with the feet and leg index). Genetic parameters from the random regression model were verified by applying a single‐trait repeatability model. Correlation coefficients between lactation EBVs from the random regression model and lactation EBVs from the repeatability model for the same claw disorder were close to 1. Correlations were lower between EBVs from single test days and lactation EBVs from the repeatability models, with a minimal value of 0.58 for PCD measured at day 20.
Challenges to Local Authorities under EU Structural Funds: Evidence from Mixed Quasi‐markets for Public Service Provision in Romania
Authors: Pop Daniel , Radu Roxana 
Published: August 2013

AbstractThe emergence of quasi‐markets – new regulatory tools to design and manage public service delivery through competition – has led to a new ecology for local authorities, who increasingly operate alongside for‐profit, not‐for‐profit and other governmental contractors for social service provision. This raises a series of challenges related to the secondary regulatory measures to correct for market and government imperfections under conditions of competition between entities with different objective functions. In shared governance systems, such as the European Union structural funds, additional tensions are generated by the double role of the public sector as purchaser and potential provider of services. This analysis presents empirical evidence from a transitional context in which quasi‐markets have been newly established, based on data from the Romanian human resource development operational programme (RO‐SOPHRD) between 2007 and 2011. These findings enhance our understanding of the dynamics of distortions created by quasi‐market environments for public service delivery in emerging economies.
Is the Convergence Party Over? Labour Productivity and the Technology Gap in Europe
Authors: Filippetti Andrea , Peyrache Antonio 
Published: August 2013

AbstractClosing the technology gap to reduce labour productivity disparities across Europe is crucial for the European cohesion policy. This article explores the sources of labour productivity growth in Europe over the period 1993–2007 in light of the enlargement process. Labour productivity growth has been mostly driven by capital accumulation. New Member States have significantly reduced their inefficiency and their technology gap. Disparities in the levels of labour productivity are still substantial and, to a considerable extent, they can be attributed to technology gap differences. This raises concerns about the process of convergence in labour productivity in Europe and suggests further policies aimed at reducing the technology gap.
Informal Politics in the EU
Authors: Christiansen Thomas , Neuhold Christine 
Published: August 2013

AbstractTraditionally, much of the focus of the study of politics has been on formal arrangements and formal institutions. In recent years, however, this dominant focus has given way to an increasing concern with informal aspects of politics. This can be said for both the study of comparative politics and international relations more generally and for research on governance within the European Union in particular. Against this background, the aim of this research note is, first, to review the findings of research on informal governance and, second, to explore whether analytical concepts can be applied to the EU, with the aim of bringing greater conceptual clarity to the field and identifying future research agendas in this area. In a final section, the article also addresses the normative dimension of informal governance in the EU, discussing both the benefits and the risks of such arrangements from the perspective of transparency, efficiency and democratic accountability.
CMT4D (NDRG1 mutation): genotype–phenotype correlations
Authors: Ricard Emilie , Mathis Stéphane , Magdelaine Corinne , Delisle Marie‐Bernadette , Magy Laurent , Funalot Benoît , Vallat Jean‐Michel 
Published: August 2013

AbstractCharcot‐Marie‐Tooth (CMT) disease is a heterogeneous condition with a large number of clinical, electrophysiological and pathological phenotypes. More than 40 genes are involved. We report a child of gypsy origin with an autosomal recessive demyelinating phenotype. Clinical data, familial history, and electrophysiological studies were in favor of a CMT4 sub‐type. The characteristic N‐Myc downstream‐regulated gene 1 (NDRG1) mutation responsible for this CMT4D phenotype was confirmed: p.R148X. The exact molecular function of the NDRG1 protein has yet to be elucidated.
FLEXIBLE RETIREMENT
Authors: van Vuuren Daniel 
Published: August 2013

AbstractFlexible retirement – that is, the opportunity to choose one's own personal retirement age – is a hedge against pension risk and provides insurance to workers facing health or productivity shocks. Flexible retirement and flexible pension schemes are in practice closely linked because of imperfect capital markets and institutional restrictions. I discuss three necessary conditions to provide insurance through flexible retirement. First, it should be possible to adjust the pension starting date at limited cost. This condition is gradually being fulfilled, as many countries are moving toward more actuarially neutral pension schemes. Second, individuals should be willing to adjust their labor supply in case of a wealth shock. This condition seems largely fulfilled, although the available empirical evidence suggests that the ‘standard retirement age’ is at least as important as the income effect. Third, the labor market should be able to deal with flexible individual retirement decisions. This condition is gaining importance, but has not yet received much attention in the literature. Institutions often hamper employment past the ‘standard retirement age’. Moreover, the hiring rates of older workers are low and their unemployment duration is high. Institutional reforms facilitating flexible retirement opportunities are desirable from an insurance perspective.
Changes in Youths' Perceived Parental Acceptance of Their Sexual Minority Status Over Time
Authors: Samarova Valeria , Shilo Guy , Diamond Gary M. 
Published: August 2013

This cross‐sectional, retrospective mixed‐method exploratory study examined 140 Israeli LGB adolescents' (14–21 year old) perceptions of their parents' level of acceptance at time of same‐sex identity disclosure and currently. Approximately 75% of respondents indicated that parents were moderately to fully accepting at time of disclosure. Approximately 15% said their parents were fully or almost fully rejecting at time of disclosure, with about half eventually becoming more accepting. Perceived parental acceptance of gay and lesbian children, but not bisexual daughters, improved over time. Increased parental acceptance was attributed to multiple factors including repeated adolescent‐initiated conversations about sexual identity, parental exposure to LGB individuals, and parental love and commitment to the relationship.
Developing Lexicons: A Review
Authors: Lawless Lydia J.R. , Civille Gail V. 
Published: August 2013

AbstractLexicons are standardized vocabularies that facilitate communication across diverse audiences. Lexicons undergo two stages (preparation and development). Lexicon preparation includes selecting suitable panelists who are highly trained and capable of describing the product category, selecting samples that represent the entire product space, and developing protocols that panelists systematically follow when creating the lexicon. The development stage includes reviewing protocols before evaluation ensues, generating terms and definitions that describe the products, selecting references that clarify the terms, reviewing examples to further train the panel on important attributes, and finalizing the lexicon. Examples of published lexicons exist for foods, beverages, home care products, personal care products and fragrances. Publishing lexicons is beneficial because it promotes standardization of sensory vocabulary across multiple panels, companies and countries. Ideally, a published lexicon has the complete list of products from which it was developed, all attribute terms, definitions for every attribute and references for every attribute.Practical ApplicationsSensory analysts working with trained descriptive panels need well defined and documented words to consistently and correctly describe products of interest. These lexicons provide a tool for communication within the panel and allow sensory analysts to communicate with product developers, marketing professionals and suppliers. Ultimately the terminology provides a basis for understanding the differences among products in a category and is the basis for designing consumer research questionnaires.Lexicons are prominent in the sensory literature. Synthesizing these publications and establishing best practices for lexicon development promotes consistency and reproducibility across the field of sensory science. Review of existing lexicons reveals criteria for successful and useful versions. As globalization spreads modern‐day businesses to new locations, consistency in sensory evaluation becomes increasingly important to establish the success of product development.
Differences in the Induction of Defence Responses in Resistant and Susceptible Muskmelon Plants Infected with Colletotrichum lagenarium
Authors: Ge Yonghong , Guest David I. , Bi Yang 
Published: August 2013

AbstractDefence reactions occurring in resistant (cv. Gankezaomi) and susceptible (cv. Ganmibao) muskmelon leaves were investigated after inoculating with Colletotrichum lagenarium. Lesion restriction in resistant cultivars was associated with the accumulation of hydrogen peroxide (H2O2). The activity of antioxidants catalase (CAT) and peroxidase (POD) significantly increased in both cultivars after inoculation, while levels of both CAT and POD activity were significantly higher in the resistant cultivar. Ascorbate peroxidase (APX) increased in both cultivars after inoculation, and level of APX activity was significantly higher in the resistant cultivar. Glutathione reductase (GR) activity significantly increased in both cultivars following inoculation, but was higher in the resistant cultivar, resulting in higher levels of ascorbic acid (AsA) and reduced glutathione (GSH). Phenylalanine ammonia lyase (PAL) significantly increased in inoculated leaves of both cultivars, resulting in higher levels of total phenolic compounds and flavonoids. The pathogenesis‐related proteins chitinase (CHT) and β‐1, 3‐glucanase (GLU) significantly increased following inoculation with higher activity in the resistant cultivar. These findings show that resistance of muskmelon plants against C. lagenarium is associated with the rapid accumulation of H2O2, resulting in altered cellular redox status, accumulation of pathogenesis‐related proteins, activation of phenylpropanoid pathway to accumulation of phenolic compounds and flavonoids.
An integrated analysis of SOCS1 down‐regulation in HBV infection‐related hepatocellular carcinoma
Authors: Zhang X. , Wang J. , Cheng J. , Ding S. , Li M. , Sun S. , Zhang L. , Liu S. , Chen X. , Zhuang H. , Lu F. 
Published: August 2013

SummaryPersistent inflammation together with genetic/epigenetic aberrations is strongly associated with chronic Hepatitis B virus (HBV) infection‐related hepatocarcinogenesis. Here, we investigated the alterations of the suppressor of cytokine signalling (SOCS) family genes in HBV‐related hepatocellular carcinoma (HCC). A total of 116 patients with HCC were enrolled in this study. The methylation statuses of SOCS1‐7 and CISH genes were quantitatively measured and clinicopathological significance of SOCS1 methylation was statistically analysed. The gene copy number variation was assayed by aCGH. Luciferase reporter assay and Western blot were used to detect the involvement of SOCS1 in p53 signalling. We found high frequencies of SOCS1 gene hypermethylation in both tumour (56.03%) and adjacent nontumour tissues (54.31%), but tumour tissues exhibited increased methylation intensity (24.01% vs 13.11%, P < 0.0001), particularly in patients with larger tumour size or cirrhosis background (P < 0.0001). In addition, the frequency and intensity of SOCS1 hypermethylation in tumour tissues were both significantly higher than those in nontumour tissues in male gender patients and in patients ≥45 years old (P = 0.0214 and P < 0.0001, P = 0.0232 and P < 0.0001, respectively). SOCS1 gene deletion was found in 8 of 25 aCGH assayed tumour specimens, which was associated with lower SOCS1 mRNA expression (P = 0.0448). Furthermore, ectopic SOCS1 overexpression could activate the p53 signalling pathway in HCC cell lines. Hypermethylation of SOCS2‐7 and CISH genes was seldom found in HCC. Our results suggested that the gene loss and epigenetic silencing of SOCS1 were strongly associated with HBV‐related HCC.
Parapatric divergence of sympatric morphs in a salamander: incipient speciation on Long Island?
Authors: Fisher‐Reid M. Caitlin , Engstrom Tag N. , Kuczynski Caitlin A. , Stephens Patrick R. , Wiens John J. 
Published: August 2013

AbstractSpeciation is often categorized based on geographic modes (allopatric, parapatric or sympatric). Although it is widely accepted that species can arise in allopatry and then later become sympatrically or parapatrically distributed, patterns in the opposite direction are also theoretically possible (e.g. sympatric lineages or ecotypes becoming parapatric), but such patterns have not been shown at a macrogeographic scale. Here, we analyse genetic, climatic, ecological and morphological data and show that two typically sympatric colour morphs of the salamander Plethodon cinereus (redback and leadback) appear to have become parapatrically distributed on Long Island, New York, with pure‐redback populations in the west and pure‐leadback populations in the east (and polymorphic populations in between and on the mainland). In addition, the pure‐leadback populations in eastern Long Island are genetically, ecologically and morphologically divergent from both mainland and other Long Island populations, suggesting the possibility of incipient speciation. This parapatric separation seems to be related to the different ecological preferences of the two morphs, preferences which are present on the mainland and across Long Island. These results potentially support the idea that spatial segregation of sympatric ecotypes may sometimes play an important part in parapatric speciation.
Optimal Clustering of Railroad Track Maintenance Jobs
Authors: Peng Fan , Ouyang Yanfeng 
Published: August 2013

AbstractRailroad job clustering is an important part of railroad track maintenance planning. It focuses on clustering track maintenance jobs into projects, so that the projects can be assigned to the production teams and scheduled in the planning horizon. The real‐world instances of job‐clustering problem usually have a very large scale, involving thousands of jobs per year. Various difficult side constraints such as mutual exclusion constraints and rounding constraints further increase the difficulty in solving the problem. In this article, we develop a mixed‐integer mathematical programming model in the form of vehicle routing problem with side constraints, and propose a set of integrated heuristic algorithms to solve the problem. The proposed model and algorithms are shown to be effective and have been adopted by a Class‐I railroad to help their practical operations for a few years.
YabA and DnaD inhibit helix assembly of the DNA replication initiation protein DnaA
Authors: Scholefield Graham , Murray Heath 
Published: August 2013

SummaryControl of DNA replication initiation is essential for cell growth. A unifying characteristic of DNA replication initiator proteins is their distinctive AAA+ nucleotide‐binding domains. The bacterial initiator DnaA assembles into a right‐handed helical oligomer built upon interactions between neighbouring AAA+ domains to form an active initiation complex. Recently we developed a unique cross‐linking assay that specifically detects ATP‐dependent DnaA helix assembly. Here we have utilized this assay to show that two DnaA regulatory proteins in Bacillus subtilis, YabA and DnaD, inhibit DnaA helix formation. These results, in combination with our previous finding that the regulatory factor Soj/ParA also targets DnaA filament formation, highlight the critical importance of regulating DnaA helix formation during the initiation reaction. Moreover, these observations lead us to suggest that DnaA oligomerization may be the main regulatory step of the initiator assembly pathway in B. subtilis, in contrast to the prevailing model of bacterial DNA replication based on Escherichia coli DnaA where ATP binding appears to be the targeted activity.