bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dioses postmodernos y mitología tecnológica: Ilión y Olympo, de Dan Simmons
Authors: López Gregoris Rosario , Unceta Gómez Luis 
Published: April 2013

Réécrire les poèmes homériques avec une pointe de science-fiction peut être considéré comme une transgression contre l’un des monuments littéraires de la civilisation occidentale, d’autant plus si cette réécriture s’opère à partir de profondes connaissances littéraires qui favorisent l’établissement d’un réseau complexe de jeux intertextuels. Ce travail prétend analyser les mécanismes de subversion des référents littéraires et mythologiques utilisés dans deux œuvres-clés de la science fiction contemporaine : Ilium et Olympos de l’auteur américain Dan Simmons.
Homeostatic Proliferation of Naive CD4+ T Cells in Mesenteric Lymph Nodes Generates Gut-Tropic Th17 Cells
Authors: Kawabe Takeshi , Sun Shu-lan , Fujita Tsuyoshi , Yamaki Satoshi , Asao Atsuko , Takahashi Takeshi , So Takanori , Ishii Naoto 
Published: April 2013

Abstract
Homeostatic proliferation of naive T cells in the spleen and cutaneous lymph nodes supplies memory–phenotype T cells. The “systemic” proliferative responses divide distinctly into fast or slow cell division rates. The fast proliferation is critical for generation of effector memory T cells. Because effector memory T cells are abundant in the lamina propria of the intestinal tissue, “gut-specific” homeostatic proliferation of naive T cells may be important for generation of intestinal effector memory T cells. However, such organ-specific homeostatic proliferation of naive T cells has not yet been addressed. In this study, we examined the gut-specific homeostatic proliferation by transferring CFSE-labeled naive CD4+ T cells into sublethally irradiated mice and separately evaluating donor cell division and differentiation in the intestine, mesenteric lymph nodes (MLNs), and other lymphoid organs. We found that the fast-proliferating cell population in the intestine and MLNs had a gut-tropic α4β7+ Th17 phenotype and that their production was dependent on the presence of commensal bacteria and OX40 costimulation. Mesenteric lymphadenectomy significantly reduced the Th17 cell population in the host intestine. Furthermore, FTY720 treatment induced the accumulation of α4β7+IL-17A+ fast-dividing cells in MLNs and eliminated donor cells in the intestine, suggesting that MLNs rather than intestinal tissues are essential for generating intestinal Th17 cells. These results reveal that MLNs play a central role in inducing gut-tropic Th17 cells and in maintaining CD4+ T cell homeostasis in the small intestine.
Local Administration of TLR Ligands Rescues the Function of Tumor-Infiltrating CD8 T Cells and Enhances the Antitumor Effect of Lentivector Immunization
Authors: Xiao Haiyan , Peng Yibing , Hong Yuan , Huang Lei , Guo Z. Sheng , Bartlett David L. , Fu Ning , Munn David H. , Mellor Andrew , He Yukai 
Published: April 2013

Abstract
Cancer vaccines, to date, have shown limited effect to control the growth of established tumors due largely to effector failure of the antitumor immune responses. Tumor lesion is characterized as chronic indolent inflammation in which the effector function of tumor-infiltrating lymphocytes (TILs) is severely impaired. In this study, we investigated whether the effector function of CD8 TILs could be rescued by converting the chronic inflammation milieu to acute inflammation within tumors. We found that injection of TLR3/9 ligands (polyI:C/CpG) into a tumor during the effector phase of lentivector (lv) immunization effectively rescued the function of lv-activated CD8 TILs and decreased the percentage of T regulatory within the tumor, resulting in a marked improvement in the antitumor efficacy of lv immunization. Mechanistically, rescue of the effector function of CD8 TILs by TLR3/9 ligands is most likely dependent on production, within a tumor, of type-1 IFN that can mature and activate tumor-infiltrating dendritic cells. The effector function of CD8 TILs could not be rescued in mice lacking intact type I IFN signaling. These findings have important implications for tumor immunotherapy, suggesting that type I IFN-mediated activation of tumor-infiltrating dendritic cells within a tumor will most likely restore/enhance the effector function of CD8 TILs and thus improve the antitumor efficacy of current cancer vaccines.
¿Son necesarias políticas públicas sobre la biblioteca escolar? Situación en América Latina
Authors: Cárdenas Zardoni Horacio 
Published: April 2013

La biblioteca escolar es uno de los recursos de mayor relevancia para para elevar el aprovechamiento de los educandos inscritos en el sistema educativo de cualquier nación. Todo país invierte cantidades sustanciales en recursos bibliotecarios para las escuelas, los cuales tienen la cualidad de permanecer e irse acumulando, con lo que al paso de los años la biblioteca escolar puede llegar a tener un importante acervo que poner al servicio de los estudiantes. Pese a su valor innegable como coadyuvante en la formación de millones de ciudadanos que cursan sus estudios en las escuelas latinoamericanas, sin embargo su capacidad instalada y su potencial distan mucho de ser capitalizado al máximo. La razón de esto es la inexistencia de políticas públicas que dispongan su plena incorporación al proceso enseñanza-aprendizaje.
Association of Cytokines, High Sensitive C-Reactive Protein, VEGF and Beta-Defensin-1 Gene Polymorphisms and Their Protein Expressions with Chronic Periodontitis in the Chinese Population
Authors: Tian Ye , Li Jin-le , Hao Liang , Yue Yuan , Wang Min , Loo Wings TY , Cheung Mary NB , Chow Louis WC , Liu Qing , Yip Adrian YS , Ng Elizabeth LY , Chow Christopher YC 
Published: April 2013

Purposes This study aimed at investigating the association between interleukin-6 (IL-6), interleukin-12 (IL-12), C-reactive protein (CRP), vascular endothelial growth factor (VEGF) and β-defensin-1 polymorphisms and the susceptibility to periodontitis in the Chinese population. Methods DNA was extracted from the blood samples of 532 healthy individuals and 122 chronic periodontitis (CP) patients enrolled in the study. The genes encoding IL-6, IL-12, CRP, VEGF and β-defensin-1 were amplified using PCR and digested with restriction enzymes. The protein expression of the abovementioned genes was determined by ELISA. Differences in the allele/genotype frequencies were assessed with the chi-square test. Results The frequencies of the C/C genotypes of IL-6, IL-12, and VEGF were higher in CP patients than healthy controls (66.3% vs 25.9%; 27.8% vs 19.9%; and 64.8% vs 52.1%, respectively). In the patients' group we also recorded frequencies of the A/A genotypes of CRP and VEGF higher than in healthy controls (63.1% vs 58.1% and 64.8% vs 35.2%, respectively). Protein production evaluated by ELISA demonstrated significant differences between CP patients and healthy controls for IL-6, IL-12, CRP, VEGF and β-defensin-1. Conclusions The genotypes of IL-6, IL-12, VEGF and β-defensin-1 and their protein productions were associated with CP in a Chinese population. Genotypes and serum levels of CRP were associated with CP, but alleles frequency showed no difference between CP patients and healthy controls.
Mémoires acadiennes de la Déportation
Authors: Viau Robert 
Published: April 2013

La Déportation est l’événement capital de l’histoire de l’Acadie — un événement qui a marqué et qui continue de marquer la culture et la société acadiennes. Dans cet article, l’auteur examine les mémoires acadiennes de la Déportation telles qu’elles se sont manifestées lors des commémorations de 1930, de 1955 et de 2005 et lors de la querelle des « excuses de la Reine ». Il examine aussi la question : « Pourquoi se souvenir? » Évoquer la Déportation ne sert-il qu’à entretenir la victimisation des Acadiens et le sentiment tragique de leur existence en tant que peuple dépossédé? Au contraire, avoir une conscience historique ne signifie-t-il pas se percevoir dans une continuité, dans un projet? Le débat entourant la Déportation est loin d’être clos et que ce soit dans les romans récents, dans les manuels d’histoire ou lors des commémorations, le sujet demeure d’actualité.
Traduire Winslow
Authors: Clarke Patrick D. 
Published: April 2013

Ce qui suit est le texte d’une allocution prononcée à l’Université de Moncton, en février 2011, dans le cadre des « Jeudis de la Librairie acadienne » (en collaboration avec le Groupe de recherche interdisciplinaire sur les cultures en contact), qui ont pour but de commenter un ouvrage jugé important et ce, en présence de l’auteur.
Do student-student interactions improve their language learning? A comparison between GTM and CLT approaches
Authors: Raissi Reza 
Published: April 2013

Nowadays most of the scholars in the field of foreign/ second language teaching emphasized on learner centered approaches of language teaching and replacing them by old ones. In this research, researcher examined two different teaching approaches which are very common in Iran where English considered as a foreign language, namely Communicative Language Teaching (CLT) and Grammar Translation Method (GTM). Two groups of thirty participants have been participated in this study namely control and treatment groups. Students of the treatment group have received the CLT instruction in which they had high amount of interaction in the considered classes during 14 weeks of the classes while students in the control group didn’t receive any interaction in the target language by implementing GTM approach. Pretest and delayed posttest have been used in this study for measuring student’s proficiency during the course instruction. Results of the experiment have been analyzed descriptively which shows that by implementing CLT among nonnative students, their general knowledge of English can be improved significantly. At the end of the research some useful pedagogical implications have been proposed by the researcher. Keywords - Language teaching and learning, interaction hypothesis, Communicative Language Teaching, Grammar Translation Method, English as a Foreign Language.
Dynamic Amorphous Zn0.17MnO2−n·0.52H2O Electrochemical Crystal Transition for Highly Reversible Zinc‐Ion Batteries with Ultrahigh Capacity and Long Lifespan
Authors: Chen Yumin , Miao Ling , Song Ziyang , Duan Hui , Lv Yaokang , Gan Lihua , Liu Mingxian 
Published: July 2024

AbstractMn‐based oxides promise high energy density and low toxicity cathodes for aqueous zinc‐ion batteries (ZIBs) but suffer from complex irreversible phase transitions, accompanied by continuous disproportionation reactions and manganese dissolution. Tailor‐made reversible and robust crystal structure in Mn‐based material is crucial and challenging. Here a controllable electrochemical oxidation induced crystal transition strategy is developed for the transformation of cubic α‐Mn2O3 into amorphous Zn0.17MnO2−n·0.52H2O, which serves as the host of Zn2+, empowering more highly accessible built‐in zincophilic sites whilst alleviating the lattice repulsion of Zn2+ (de)intercalation. As confirmed by crystal structure evolution characterizations and theoretical simulations, the amorphous Zn0.17MnO2−n·0.52H2O with excellent electronic properties and low zinc‐ion migration barrier can be reversibly converted into ZnMn3O7·3H2O. This stabilized dynamic electrochemical crystal transition equilibrium contributes ultrahigh capacity (558 mAh g−1), high‐energy density (696 Wh kg−1@6 kW kg−1), and superior stability (5000 cycles). The approach can also extend to Mn3O4 and α‐MnO2, opening new insights into electrochemical oxidation induced crystal conversion to build highly reversible and durable ZIBs.
Tough Supramolecular Hydrogels Crafted via Lignin‐Induced Self‐Assembly
Authors: Pan Xiaofeng , Pan Jiawei , Li Xiang , Wang Zhongkai , Ni Yonghao , Wang Qinhua 
Published: July 2024

AbstractSupramolecular hydrogels are typically assembled through weak non‐covalent interactions, posing a significant challenge in achieving ultra strength. Developing a higher strength based on molecular/nanoscale engineering concepts is a potential improvement strategy. Herein, a super‐tough supramolecular hydrogel is assembled by gradually diffusing lignosulfonate sodium (LS) into a polyvinyl alcohol (PVA) solution. Both simulations and analytical results indicate that the assembly and subsequent enhancement of the crosslinked network are primarily attributed to LS‐induced formation and gradual densification of strong crystalline domains within the hydrogel. The optimized hydrogel exhibits impressive mechanical properties with tensile strength of ≈20 MPa, Young's modulus of ≈14 MPa, and toughness of ≈50 MJ m⁻3, making it the strongest lignin‐PVA/polymer hydrogel known so far. Moreover, LS provides the supramolecular hydrogel with excellent low‐temperature stability (<‐60 °C), antibacterial, and UV‐blocking capability (≈100%). Interestingly, the diffusion ability of LS is demonstrated for self‐restructuring damaged supramolecular hydrogel, achieving 3D patterning on hydrogel surfaces, and enhancing the local strength of the freeze‐thaw PVA hydrogel. The goal is to foster a versatile hydrogel platform by combining eco‐friendly LS with biocompatible PVA, paving the way for innovation and interdisciplinarity in biomedicine, engineering materials, and forestry science.
Albumin‐Loaded Silica Nanomaterials Functionalized with Organotin(IV) Agents: Theranostic Materials Against Triple‐Negative Breast Cancer
Authors: García‐Almodóvar Victoria , Ovejero‐Paredes Karina , Díaz‐García Diana , Méndez‐Arriaga José M. , Prashar Sanjiv , Filice Marco , Gómez‐Ruiz Santiago 
Published: July 2024

AbstractThe current search for more effective and milder cancer treatments has led to the development of a wide variety of multifunctional nanoplatforms that are designed to both diagnose and treat cancer. In this study, the optimization of the synthesis of theranostic materials based on mesoporous silica nanoparticles (MSNs) functionalized with different cytotoxic (organotin(IV) compounds), imaging (fluorescein and/or indocyanine green), and targeting agents of interest, such as albumin (HA), is achieved by using different strategies. These systems shows good cytotoxic capacity against triple negative breast cancer (TNBC) cells (MDA‐MB‐231) in MTT (dimethylthiazolyl‐diphenyl‐tetrazolium bromide) assays and confocal analysis shows that the incorporation of HA as a potential active targeting molecule may enhance the cellular uptake of the nanomaterial, and thus, increasing its therapeutic potential. The analysis of the results and the effect of the imaging, targeting, and cytotoxic fragments should allow a more in‐depth study of these materials in other in vitro and/or in vivo models.
Fabrication of polydopamine‐modified cellulose hydrogel for controlled release of α‐mangostin
Authors: Phan Hoang Lich , Tran Ngoc Cam Trang , Le Thi Hoang Yen , Le Quoc‐Viet , Le Tran‐Thai‐Duong , Thach Ut Dong 
Published: July 2024

AbstractHydrogels are notable for their outstanding absorbent qualities, satisfactory compatibility with biological systems, ability to degrade, and inherent safety, all of which contribute to their high demand in the field of biomedicine. This study focuses on the fabrication of hydrogels using environmentally friendly cellulosic material. Cellulose hydrogel beads were prepared by physical cross‐linking in a NaOH/urea medium. Furthermore, nano polydopamine was integrated into the hydrogel matrix as functional polymers and α‐mangostin was employed as an active pharmaceutical ingredient. The physicochemical properties were comprehensively analyzed using Fourier‐transform infrared spectrometer, 13C cross‐polarization/magic angle spinning nuclear magnetic resonance, thermogravimetric analysis, and scanning electron microscope. The drug delivery properties, including water content, swelling ratio, and drug release profiles, were evaluated. In vitro cytotoxicity against MC3T3‐E1 cells was assessed using sulforhodamine B staining. All test hydrogels exhibited inhibitory activity against the growth of MC3T3‐E1 cells. These results indicated the potential use of these hydrogels as a drug delivery carrier for α‐mangostin in the treatment of ankylosing spondylitis.
Revolutionizing Lab‐Scale Electrochemical Reactors: Innovative Breakthroughs With 3D Printing Fabrication
Authors: Granados‐Fernández Rafael , Cárdenas‐Arenas Andrea , Montiel Miguel A. 
Published: July 2024

AbstractAn efficient and successful electrochemical process must take place in an electrochemical reactor with an adapted and optimized design that allows superior performance to be achieved. Traditional manufacturing methods have made the task of optimizing and adapting reactors very expensive. However, 3D printing allows prototypes to be built in a very short time and at a very low cost compared to traditional manufacturing techniques. This has caused research into new electrochemical reactors in different laboratories to skyrocket in recent years. The rapid evolution of 3D printing technology, as well as the appearance of new materials, have meant that they can be included in many applications, such as the electrochemical treatment of contaminated water or energy devices, batteries or fuel cells. In this review, the latest advances in the manufacture of electrochemical reactors and the main applications that have made use of them will be presented and critically discussed.
Development of a Co3O4/rGO Modified Electrochemical Sensor for Highly Sensitive Riboflavin Detection
Authors: Uwaya Gloria Ebube , Sappidi Praveen Kumar , Bisetty Krishna 
Published: July 2024

AbstractThe monitoring of antioxidants is crucial to prevent damage caused by reactive oxygen species (ROS). In this study, we introduce an innovative electrochemical sensor tailored for detecting riboflavin (RF), a powerful antioxidant. The sensor was developed by modifying a gold electrode (AuE) with cobalt oxide (Co3O4) and reduced graphene oxide (rGO). The resulting nanocomposite‐modified electrode (AuE/Co3O4‐rGO) exhibited a substantial surface area of 0.41 cm2 in the redox probe, leading to an enhanced RF peak characterized by remarkably low charge transfer resistance (1.61 KΩ) and a high exchange current density (18.6 μA/cm2). Under optimized conditions, the sensor achieved a limit of detection (LOD) for RF at 1.30 μM, over a concentration range of 6.5–42.2 μM. These results highlight the sensor's potential applicability in real‐world scenarios, including the analysis of milk and pharmaceutical samples. A kinetics study revealed that the electrochemical reaction involving RF is adsorption‐controlled, emphasising the critical role of surface interactions. The modified electrode's interaction with RF significantly influences overall reaction kinetics. These findings were further supported by density functional theory (DFT) calculations and molecular simulations. Our nanocomposite‐modified electrode provides valuable insights into the atomistic interactions governing sensor performance, advancing the field of electrochemical sensing for antioxidants like riboflavin.
Efficient Adsorption and Elimination of Tm3+ for Enhanced Seed Germination Using Pillar[5]Arene Polymer
Authors: Bahojb Noruzi Ehsan , Xu Weiwei , Li Guang , Qu Haonan , Ma Cuiguang , Zhang Haifan , He Qiang , Periyasami Govindasami , Li Haibing 
Published: July 2024

AbstractWhile rare earth elements (REEs) are essential for modern technology, their production methods raise concerns for agriculture. Researchers are now exploring ways to control and recycle REEs pollution, aiming to minimize agricultural impacts and potentially even develop methods to utilize these elements for improved crop yields. Regarding this issue, a new type of pillar[5]arene polymer (Pol‐P[5]‐BTZP) has been designed and synthesized by click reaction to enhance the efficiency of adsorption and recovery of rare earth metals. This polymer incorporates the unique structure of 2,6‐di‐1,2,3‐triazolyl‐pyridine. The results of various analyses revealed that Pol‐P[5]‐BTZP exhibits excellent thermal stability, a high specific surface area, and well‐distributed networks of micropores and mesoporous structures. The adsorption capacity of Pol‐P[5]‐BTZP for Tm3+, a representative REE, was evaluated using the Langmuir and Freundlich isothermal adsorption models with a maximum adsorption capacity (Qmax) of 127.71 mg/g. Furthermore, the versatility of Pol‐P[5]‐BTZP in adsorption and recovering various REEs was tested. In addition to its adsorption capabilities, the potential of Pol‐P[5]‐BTZP for rare earth recovery and reuse was assessed through experiments on the impact of Tm3+ and La3+ on seed germination. These experiments demonstrated the wide‐ranging applicability of Pol‐P[5]‐BTZP in recovering and reusing REEs for green agriculture.
Benchmarking the potential of a resistant green hydrocolloid for chemical enhanced oil recovery from sandstone reservoirs
Authors: Nowrouzi Iman , Mohammadi Amir H. , Khaksar Manshad Abbas 
Published: July 2024

AbstractPolymer injection into oil reservoirs stands as a primary technique for enhanced oil recovery (EOR), employing either natural or synthetic polymers that dissolve in water. Proper performance in salinity and reservoir temperature creates a limitation to replace natural material with common chemicals and this has led researchers to try to identify new material for this application. Continuing the efforts and overcoming the challenge, this research introduces and examines a high‐performance natural polymer extracted from garden cress seeds for this application. Several experiments were planned and executed based on the existing EOR standards and literature. Comprehensive analyses and viscosity measurements were performed to identify the behaviour of solutions and the effects of concentration, shear rate, salinity, and temperature. Essential tests such as wettability and polymer adsorption were also done by contact angle measurement and flooding into a sandstone plug, respectively. The produced polymer was able to effectively maintain the viscosification properties at temperatures up to 95°C. Similarly, increasing the salinity up to 140,000 ppm did not affect its efficiency and the viscosity value remained in the useful range. The viscosity of the mature solutions at 35°C after 30 h at concentrations of 200, 400, 600, 800, 1000, and 1200 ppm was 8.61, 18.59, 31.27, 65.41, 95.38, and 149.75 mPa, respectively. At 1000 ppm and temperatures of 35, 55, 75, and 95°C, the viscosity was 95.38, 90.57, 86.73, and 84.72 mPa · s, respectively. At concentrations of 600, 800, and 1000 ppm, the wettability altered to intermediate‐wet, while at 1200 ppm, altered to water‐wet. Polymer injection caused an increase in recovery equal to 18.6%. The water cut increased with a little delay in the initial volumes of water injection at a high rate and reached its maximum. Then after the injection of 0.3 PV of polymer, there was a sharp and continuous drop until reaching 35% of the production fluid volume.