bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medical Reasons Behind Player Departures From Male and Female Professional Tennis Competitions
Authors: Okholm Kryger Katrine , Dor Frédéric , Guillaume Marion , Haida Amal , Noirez Philippe , Montalvan Bernard , Toussaint Jean-François 
Published: November 2014

Background: The number of retirements, withdrawals, and “lucky losers” (the replacement of a player who withdraws before the start of the tournament by a losing player from the qualifying round) from professional tennis tournaments has increased, but the reasons behind such departures have not yet been analyzed. An official consensus statement has been conducted to allow a general categorization of injuries in tennis. Purpose: To determine the reasons for departure and injury rates in professional tennis. Study Design: Descriptive epidemiology study. Methods: All reasons for departures were collected from official Association of Tennis Professionals (ATP) and Women’s Tennis Association (WTA) web pages. All tournaments apart from the 4 major competitions (the Australian Open, French Open, Wimbledon, and US Open) were included for the period 2001-2012 for men and women. Personal data, tournament information, surface, match setting, date, and reason were obtained for each departure scenario. Results: Variations in departure and injury rates were seen throughout the season. Women left and were injured significantly more than men. Women mainly left because of thigh injuries, whereas men left mainly because of back injuries. Playing surface only had an influence on the risk of lower back injuries. Only women’s departures were affected by the tournament round. Conclusion: A high number of departures from tournaments have occurred during the past 10 years on the ATP and WTA circuits. Injuries were the main reasons of these departures, regardless of the type of departure and player sex. The back and thigh were the main locations of injuries for men and women, respectively.
Prevalence and Description of Palliative Care in US Nursing Homes
Authors: Lester Paula E. , Stefanacci Richard G. , Feuerman Martin 
Published: November 2014

Objective: To describe rates and policies in U.S. Nursing Homes (NH) related to palliative care, comfort care, and hospice care based on a nationwide survey of directors of nursing. Measurements: A national survey was distributed online and was completed by 316 directors of nursing of NHs (11% response rate). The directors of nursing were asked about availability and policies in their facilities. Specifically, questions were related to policies, referral patterns, discussion about such care, and types of medical conditions qualifying for such services. Results: Hospice is significantly more available than palliative or comfort care programs; also, for-profit facilities, compared to non-profits, are significantly more likely to have palliative care programs and medical directors for palliative care. Social workers and nurses were most likely to suggest palliative type programs. Only 42% of facilities with palliative program provide consultation by a palliative certified physician. Residents with non-healing pressure ulcers, frequent hospitalizations, or severe/uncontrolled pain or non-pain symptoms were less likely to be referred. Conclusions: There is limited availability of palliative type programs in NH facilities and underutilization in those NH with programs.
Open Fractures of the Foot and Ankle
Authors: Manway Jeffrey , Highlander Peter 
Published: November 2014

Open fractures have been associated with high rates of morbidity and mortality. Morbidity and mortality rates have improved with the advancements in infectious disease, plastic and reconstructive surgery, as well as damage control orthopaedics. Despite these advancements, few reports have focused on management of open foot and ankle fractures. This review outlines evidence-based principles for open fracture management and how these principles are applied to the foot and ankle. Levels of Evidence: Level V, Expert Opinion
Transcription factor IRF8 plays a critical role in the development of murine basophils and mast cells
Authors: Sasaki Haruka , Kurotaki Daisuke , Osato Naoki , Sato Hideaki , Sasaki Izumi , Koizumi Shin-ichi , Wang Hongsheng , Kaneda Chika , Nishiyama Akira , Kaisho Tsuneyasu , Aburatani Hiroyuki , Morse Herbert C. , Ozato Keiko , Tamura Tomohiko 
Published: November 2014

Key Points
IRF8 promotes Gata2 expression in GPs, thereby playing a key role in the development of basophils and mast cells.
Myosin-II repression favors pre/proplatelets but shear activation generates platelets and fails in macrothrombocytopenia
Authors: Spinler Kyle R. , Shin Jae-Won , Lambert Michele P. , Discher Dennis E. 
Published: November 2014

Key PointsMyosin-II inhibition (with blebbistatin) and MYH9-RD mutations enhance shear fragmentation to pre/proplatelet sizes. Sustained shear activates normal myosin-II, which then favors division of pre/proplatelets to smaller platelets.
Boost and loss of immune responses against tumor-associated antigens in the course of pregnancy as a model for allogeneic immunotherapy
Authors: Lutz Mathias , Worschech Andrea , Alb Miriam , Gahn Sabine , Bernhard Laura , Schwab Michael , Obermeier Stefanie , Einsele Hermann , Kämmerer Ulrike , Heuschmann Peter , Klinker Erdwine , Otto Christoph , Mielke Stephan 
Published: November 2014

Key PointsPregnancy recalls short-lived immunity against TAAs mimicking antileukemic responses after allogeneic stem cell transplantation.
Riociguat for the treatment of chronic thromboembolic pulmonary hypertension: a long-term extension study (CHEST-2)
Authors: Simonneau Gérald , D’Armini Andrea M. , Ghofrani Hossein-Ardeschir , Grimminger Friedrich , Hoeper Marius M. , Jansa Pavel , Kim Nick H. , Wang Chen , Wilkins Martin R. , Fritsch Arno , Davie Neil , Colorado Pablo , Mayer Eckhard 
Published: November 2014

Riociguat is a soluble guanylate cyclase stimulator approved for the treatment of inoperable and persistent/recurrent chronic thromboembolic pulmonary hypertension (CTEPH). In the 16-week CHEST-1 study, riociguat showed a favourable benefit–risk profile and improved several clinically relevant end-points in patients with CTEPH. The CHEST-2 open-label extension evaluated the long-term safety and efficacy of riociguat.Eligible patients from CHEST-1 received riociguat individually adjusted up to a maximum dose of 2.5 mg three times daily. The primary objective was the safety and tolerability of riociguat; exploratory efficacy end-points included 6-min walking distance (6MWD) and World Health Organization (WHO) functional class (FC).Overall, 237 patients entered CHEST-2 and 211 (89%) were ongoing at this interim analysis (March 2013). The safety profile of riociguat in CHEST-2 was similar to CHEST-1, with no new safety signals. Improvements in 6MWD and WHO FC observed in CHEST-1 persisted for up to 1 year in CHEST-2. In the observed population at 1 year, mean±sd6MWD had changed by +51±62 m (n=172)versusCHEST-1 baseline (n=237), and WHO FC had improved/stabilised/worsened in 47/50/3% of patients (n=176)versusCHEST-1 baseline (n=236).Long-term riociguat had a favourable benefit–risk profile and apparently showed sustained benefits in exercise and functional capacity for up to 1 year.
A contemporary survival analysis of individuals with cystic fibrosis: a cohort study
Authors: Stephenson Anne L. , Tom Melissa , Berthiaume Yves , Singer Lianne G. , Aaron Shawn D. , Whitmore G.A. , Stanojevic Sanja 
Published: November 2014

Previously established predictors of survival may no longer apply in the current era of cystic fibrosis (CF) care. Our objective was to identify risk factors associated with survival in a contemporary CF population.We used the Canadian CF Registry, a population-based cohort, to calculate median age of survival and summarise patient characteristics from 1990 to 2012. Clinical, demographic and geographical factors, and survival were estimated for a contemporary cohort (2000–2012) using Cox proportional hazards models.There were 5787 individuals in the registry between 1990 and 2012. Median survival age increased from 31.9 years (95% CI 28.3–35.2 years) in 1990 to 49.7 years (95% CI 46.1–52.2 years) in the most current 5-year window ending in 2012. Median forced expiratory volume in 1 s improved (p=0.04) and fewer subjects were malnourished (p<0.001) over time. Malnourished patients (hazard ratio (HR) 2.1, 95% CI 1.6–2.8), those with multiple exacerbations (HR 4.5, 95% CI 3.2–6.4) and women with CF-related diabetes (HR 1.8, 95% CI 1.2–2.7) were at increased risk of death.Life expectancy in Canadians with CF is increasing. Modifiable risk factors such as malnutrition and pulmonary exacerbations are associated with an increased risk of death. The sex gap in CF survival may be explained by an increased hazard for death in women with CF-related diabetes.
A moving direction prediction-assisted handover scheme in LTE networks
Authors: Wang Hsiu-Lang , Kao Shang-Juh , Hsiao Chung-Yi , Chang Fu-Min 
Published: November 2014

Abstract
The 3rd Generation Partnership Project (3GPP) Long Term Evolution (LTE) defines a wireless network standard for high packet transmission rate and low packet latency provisions. Handover is one of the important features for helping user equipments (UEs) to roam between LTE networks. However, LTE networks adapt a make-before-break handover procedure, which may cause a brief disconnection, therefore results in the packet transmission delay and packet loss problems. In this paper, we propose a moving direction prediction-assisted handover scheme for LTE networks to lower the number of handovers. We first track the location of user equipments (UEs) to predict their moving direction. By referencing previous locations, the next moving direction of UEs is estimated with the cosine function in order to determine the candidate E-UTRAN NodeBs (eNBs) for handover. Then, a target eNB is selected from the candidate eNBs through an angle-based dynamic weight adjustment scheme. By selecting a proper target eNB for handover, thus the quality of network transmission can be enhanced. Simulation results demonstrate the ability of the proposed scheme in reducing 17% average handover times, compared with the standard handover procedure, thereby reducing 12% average number of packet loss and 5% average packet delay time.
A migrant study of pubertal timing and tempo in British-Bangladeshi girls at varying risk for breast cancer
Authors: Houghton Lauren C , Cooper Gillian D , Bentley Gillian R , Booth Mark , Chowdhury Osul A , Troisi Rebecca , Ziegler Regina G , Hoover Robert N , Katki Hormuzd A 
Published: November 2014

Abstract
Introduction
Earlier menarche is related to subsequent breast cancer risk, yet international differences in the age and tempo of other pubertal milestones and their relationships with body mass index (BMI) are not firmly established in populations at differing risk for breast cancer. We compared age and tempo of adrenarche, thelarche, pubarche, and menarche in a migrant study of Bangladeshi girls to the United Kingdom (UK) and assessed whether differences by migration were explained by differences in BMI.

Methods
Included were groups of Bangladeshi (n =168), British-Bangladeshi (n =174) and white British (n =54) girls, aged 5 to 16 years. Interviewer-administered questionnaires obtained pubertal staging; height and weight were measured. Salivary dehydroepiandrosterone-sulfate concentrations >400 pg/ml defined adrenarche. Median ages of pubertal milestones and hazard ratios (HR) with 95% confidence intervals (CI) were estimated from Weibull survival models.

Results
In all three groups, adrenarche occurred earliest, followed by thelarche, pubarche, and finally menarche. Neither median age at adrenarche (Bangladeshi = 7.2, British-Bangladeshi = 7.4, white British = 7.1; P-trend = 0.70) nor at menarche (Bangladeshi = 12.5, British-Bangladeshi = 12.1, white British = 12.6; P-trend = 0.70) differed across groups. In contrast, median age at thelarche (Bangladeshi = 10.7, British-Bangladeshi = 9.6, white British = 8.7; P-trend <0.01) occurred earlier among girls living in the UK. Compared with Bangladeshi girls, HRs (95% CI) for earlier thelarche were 1.6 (1.1 to 2.4) for British-Bangladeshi girls and 2.6 (1.5 to 4.4) for white British girls (P-trend <0.01), but were attenuated after adjustment for BMI (British-Bangladeshi = 1.1 (0.7 to 1.8), white British = 1.7(1.0 to 3.1); P-trend =0.20).

Conclusions
Thelarche occurred earlier, but puberty progressed slower with increasing exposure to the UK environment; differences were partially explained by greater BMI. The growth environment might account for much of the ethnic differences in pubertal development observed across and within countries.
Lighter: fast and memory-efficient sequencing error correction without counting
Authors: Song Li , Florea Liliana , Langmead Ben 
Published: November 2014

AbstractLighter is a fast, memory-efficient tool for correcting sequencing errors. Lighter avoids counting k-mers. Instead, it uses a pair of Bloom filters, one holding a sample of the input k-mers and the other holding k-mers likely to be correct. As long as the sampling fraction is adjusted in inverse proportion to the depth of sequencing, Bloom filter size can be held constant while maintaining near-constant accuracy. Lighter is parallelized, uses no secondary storage, and is both faster and more memory-efficient than competing approaches while achieving comparable accuracy.
A genomic and evolutionary approach reveals non-genetic drug resistance in malaria
Authors: Herman Jonathan D , Rice Daniel P , Ribacke Ulf , Silterra Jacob , Deik Amy A , Moss Eli L , Broadbent Kate M , Neafsey Daniel E , Desai Michael M , Clish Clary B , Mazitschek Ralph , Wirth Dyann F 
Published: November 2014

Abstract
Background
Drug resistance remains a major public health challenge for malaria treatment and eradication. Individual loci associated with drug resistance to many antimalarials have been identified, but their epistasis with other resistance mechanisms has not yet been elucidated.

Results
We previously described two mutations in the cytoplasmic prolyl-tRNA synthetase (cPRS) gene that confer resistance to halofuginone. We describe here the evolutionary trajectory of halofuginone resistance of two independent drug resistance selections in Plasmodium falciparum. Using this novel methodology, we discover an unexpected non-genetic drug resistance mechanism that P. falciparum utilizes before genetic modification of the cPRS. P. falciparum first upregulates its proline amino acid homeostasis in response to halofuginone pressure. We show that this non-genetic adaptation to halofuginone is not likely mediated by differential RNA expression and precedes mutation or amplification of the cPRS gene. By tracking the evolution of the two drug resistance selections with whole genome sequencing, we further demonstrate that the cPRS locus accounts for the majority of genetic adaptation to halofuginone in P. falciparum. We further validate that copy-number variations at the cPRS locus also contribute to halofuginone resistance.

Conclusions
We provide a three-step model for multi-locus evolution of halofuginone drug resistance in P. falciparum. Informed by genomic approaches, our results provide the first comprehensive view of the evolutionary trajectory malaria parasites take to achieve drug resistance. Our understanding of the multiple genetic and non-genetic mechanisms of drug resistance informs how we will design and pair future anti-malarials for clinical use.
The conjunctival microbiome in health and trachomatous disease: a case control study
Authors: Zhou Yanjiao , Holland Martin J , Makalo Pateh , Joof Hassan , Roberts Chrissy h , Mabey David CW , Bailey Robin L , Burton Matthew J , Weinstock George M , Burr Sarah E 
Published: November 2014

Abstract
Background
Trachoma, caused by Chlamydia trachomatis, remains the worlds leading infectious cause of blindness. Repeated ocular infection during childhood leads to scarring of the conjunctiva, in-turning of the eyelashes (trichiasis) and corneal opacity in later life. There is a growing body of evidence to suggest non-chlamydial bacteria are associated with clinical signs of trachoma, independent of C. trachomatis infection.

Methods
We used deep sequencing of the V1-V3 region of the bacterial 16S rRNA gene to characterize the microbiome of the conjunctiva of 220 residents of The Gambia, 105 with healthy conjunctivae and 115 with clinical signs of trachoma in the absence of detectable C. trachomatis infection. Deep sequencing was carried out using the Roche-454 platform. Sequence data were processed and analyzed through a pipeline developed by the Human Microbiome Project.

Results
The microbiome of healthy participants was influenced by age and season of sample collection with increased richness and diversity seen in younger participants and in samples collected during the dry season. Decreased diversity and an increased abundance of Corynebacterium and Streptococcus were seen in participants with conjunctival scarring compared to normal controls. Abundance of Corynebacterium was higher still in adults with scarring and trichiasis compared to adults with scarring only.

Conclusions
Our results indicate that changes in the conjunctival microbiome occur in trachomatous disease; whether these are a cause or a consequence is yet unknown.
The National Practice Benchmark for Oncology, 2014 Report on 2013 Data
Authors: Towle Elaine L. , Barr Thomas R. , Senese James L. 
Published: November 2014

The National Practice Benchmark (NPB) is a unique tool to measure oncology practices against others across the country in a way that allows meaningful comparisons despite differences in practice size or setting. In today's economic environment every oncology practice, regardless of business structure or affiliation, should be able to produce, monitor, and benchmark basic metrics to meet current business pressures for increased efficiency and efficacy of care. Although we recognize that the NPB survey results do not capture the experience of all oncology practices, practices that can and do participate demonstrate exceptional managerial capability, and this year those practices are recognized for their participation. In this report, we continue to emphasize the methodology introduced last year in which we reported medical revenue net of the cost of the drugs as net medical revenue for the hematology/oncology product line. The effect of this is to capture only the gross margin attributable to drugs as revenue. New this year, we introduce six measures of clinical data density and expand the radiation oncology benchmarks.
TRPV1 mediates cellular uptake of anandamide and thus promotes endothelial cell proliferation and network-formation
Authors: Hofmann Nicole A. , Barth Sonja , Waldeck-Weiermair Markus , Klec Christiane , Strunk Dirk , Malli Roland , Graier Wolfgang F. 
Published: November 2014

ABSTRACT
Anandamide (N-arachidonyl ethanolamide, AEA) is an endogenous cannabinoid that is involved in various pathological conditions, including cardiovascular diseases and tumor-angiogenesis. Herein, we tested the involvement of classical cannabinoid receptors (CBRs) and the Ca2+-channel transient receptor potential vanilloid 1 (TRPV1) on cellular AEA uptake and its effect on endothelial cell proliferation and network-formation. Uptake of the fluorescence-labeled anandamide (SKM4-45-1) was monitored in human endothelial colony-forming cells (ECFCs) and a human endothelial-vein cell line (EA.hy926). Involvement of the receptors during AEA translocation was determined by selective pharmacological inhibition (AM251, SR144528, CID16020046, SB366791) and molecular interference by TRPV1-selective siRNA-mediated knock-down and TRPV1 overexpression. We show that exclusively TRPV1 contributes essentially to AEA transport into endothelial cells in a Ca2+-independent manner. This TRPV1 function is a prerequisite for AEA-induced endothelial cell proliferation and network-formation. Our findings point to a so far unknown moonlighting function of TRPV1 as Ca2+-independent contributor/regulator of AEA uptake. We propose TRPV1 as representing a promising target for development of pharmacological therapies against AEA-triggered endothelial cell functions, including their stimulatory effect on tumor-angiogenesis.
Pre-metazoan origins and evolution of the cadherin adhesome
Authors: Murray Paul S. , Zaidel-Bar Ronen 
Published: November 2014

ABSTRACT
Vertebrate adherens junctions mediate cell–cell adhesion via a “classical” cadherin–catenin “core” complex, which is associated with and regulated by a functional network of proteins, collectively named the cadherin adhesome (“cadhesome”). The most basal metazoans have been shown to conserve the cadherin–catenin “core”, but little is known about the evolution of the cadhesome. Using a bioinformatics approach based on both sequence and structural analysis, we have traced the evolution of this larger network in 26 organisms, from the uni-cellular ancestors of metazoans, through basal metazoans, to vertebrates. Surprisingly, we show that approximately 70% of the cadhesome, including proteins with similarity to the catenins, predate metazoans. We found that the transition to multicellularity was accompanied by the appearance of a small number of adaptor proteins, and we show how these proteins may have helped to integrate pre-metazoan sub-networks via PDZ domain–peptide interactions. Finally, we found the increase in network complexity in higher metazoans to have been driven primarily by expansion of paralogs. In summary, our analysis helps to explain how the complex protein network associated with cadherin at adherens junctions first came together in the first metazoan and how it evolved into the even more complex mammalian cadhesome.
Rückkehr zur Lehre vorn gerechten Krieg?
Authors: Huber Wolfgang 
Published: November 2014

Abstract
The wars in Kosovo ( 1999), Afghanistan (2001) and Iraq (2003) have caused some German Theologians and Church Leaderstoplead for a renewal of the classical doctrine of just war, maybe modified into thc form of the so-called »just and limited war«- theory. In contrast to this it is obvious that the concept of »just peace« bears the basic idea of contemporary Christian Peace Ethics. This idea should of coursenot be understood as a complete contradiction to the doctrine of just war since the criteria ( e.g. ultima ratio) that are part of this doctrine, which were always intended to prevent and to Iimit warfare and violence, reappear within the concept of just peace. Therefore the doctrine of just peace is no synonym for pacifism. Two key arguments should be considered: (1) The doctrine of just peace names the goal and measure of all policy which is peace and peace alone. Never can war be the aim of policy, especially when policy is inspired by Christi an faith. The doctrine of just war is likely to overlook this logical connection. (2) The notion »just peace« emphasizes the unity and interdependence of peace, law and justice. Peace can only grow where law and justice prosper and vice versa. So »just peace« is much more substantial than the term »just war«. In any case another problern must be solved: It is not clear if the criteria included in both concepts have tobe combined by the logical figure of a conjunction or a disjunction.