bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mating competitiveness and life‐table comparisons between transgenic and Indian wild‐type Aedes aegypti L.
Authors: Patil Prabhakargouda B , Niranjan Reddy BP , Gorman Kevin , Seshu Reddy KV , Barwale Shirish R , Zehr Usha B , Nimmo Derric , Naish Neil , Alphey Luke 
Published: July 2014

AbstractBACKGROUNDOX513A is a genetically engineered strain of Aedes aegypti carrying a repressible, dominantly inherited transgene that confers lethality in immature heterozygous progeny. Released male OX513A adults have proven to be effective for the localised suppression of wild Ae. aegypti, highlighting its potential in vector control. Mating and life‐table assessments were used to compare OX513A with reared Ae. aegypti strains collected from New Delhi and Aurangabad regions in India.RESULTSMating proportions of New Delhi females versus males of OX513A or New Delhi strains were 0.52 and 0.48 respectively, indicating no discrimination by females against either strain, and males of both strains were equally competitive. Developmental time from first instar to adult emergence was significantly longer for OX513A (10.7 ± 0.04 days) than for New Delhi (9.4 ± 0.04 days) and Aurangabad strains (9.1 ± 0.04 days). Differences in mean longevities, female reproductive parameters and population growth parameters between the strains were non‐significant.CONCLUSIONSThe laboratory study demonstrates that only minor life‐table variations of limited biological relevance exist between OX513A and Indian Ae. aegypti populations, and males had equal potential for mating competitiveness. Thus, results support the OX513A strain as a suitable candidate for continued evaluation towards sustainable management of Ae. aegypti populations in India. © 2014 Gangabishan Bhikulal Investment and Trading Limited. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Using social media as a tool for business improvement and certification of knowledge workers
Authors: Colomo‐Palacios Ricardo , Messnarz Richard , Siakas Kerstin , Palosi Daniel , Coakley Darragh 
Published: July 2014

ABSTRACTBusiness improvement is a hot topic in all business areas. In the last years, the unstoppable emergence of the use of social media by organizations and individuals alike has opened this tool for knowledge networking purposes. In this paper, the authors shed some light on how the traditional knowledge management approach has changed to a networked approach of knowledge sharing. Authors also explain how social media is used as a business tool, in particular in Information Technology industry environments. ECQA Certified Social Media Networker Skills (SIMS) is a new qualification that is available from 2013 and is meant to train and certify experts in the use of social media as a business improvement enabler and as a means for knowledge networking in organizational settings. Copyright © 2014 John Wiley & Sons, Ltd.
Normalized least mean square‐based adaptive sparse filtering algorithms for estimating multiple‐input multiple‐output channels
Authors: Gui Guan , Xu Li , Adachi Fumiyuki 
Published: July 2014

AbstractThis paper studies normalized least mean square‐based adaptive sparse filtering algorithms for estimating multiple‐input multiple‐output (MIMO) channels. Although the MIMO channel is often modeled as sparse, traditional normalized least mean square‐based filtering algorithm never takes the advantage of the inherent sparse structure information and thus causes some performance loss. Unlike the traditional method, the proposed two adaptive sparse channel estimation methods exploit the sparse structure information of MIMO channels. To validate the effectiveness of proposed MIMO channel estimates, theoretical analysis and simulation results are provided. We derive steady‐state mean‐square deviations of the proposed MIMO channel estimates and theoretically show that it is better than the traditional one. Moreover, their performance advantages are confirmed by computer simulations. Copyright © 2014 John Wiley & Sons, Ltd.
Interdisciplinarity as cognitive integration: auditory verbal hallucinations as a case study
Authors: Bernini Marco , Woods Angela 
Published: July 2014

In this article, we advocate a bottom‐up direction for the methodological modeling of interdisciplinary research based on concrete interactions among individuals within interdisciplinary projects. Drawing on our experience in Hearing the Voice (a cross‐disciplinary project on auditory verbal hallucinations running at Durham University), we focus on the dynamic if also problematic integration of cognitive science (neuroscience, cognitive psychology, and of mind), phenomenology, and humanistic disciplines (literature, narratology, history, and theology). We propose a new model for disciplinary integration which brings to the fore an under‐investigated dynamic of interdisciplinary projects, namely their being processes of distributed cognition and cognitive integration. WIREs Cogn Sci 2014, 5:603–612. doi: 10.1002/wcs.1305This article is categorized under:

Philosophy > Knowledge and Belief
Lipid metabolism in mitochondrial membranes
Authors: Mayr Johannes A. 
Published: July 2014

AbstractMitochondrial membranes have a unique lipid composition necessary for proper shape and function of the organelle. Mitochondrial lipid metabolism involves biosynthesis of the phospholipids phosphatidylethanolamine, cardiolipin and phosphatidylglycerol, the latter is a precursor of the late endosomal lipid bis(monoacylglycero)phosphate. It also includes mitochondrial fatty acid synthesis necessary for the formation of the lipid cofactor lipoic acid. Furthermore the synthesis of coenzyme Q takes place in mitochondria as well as essential parts of the steroid and vitamin D metabolism. Lipid transport and remodelling, which are necessary for tailoring and maintaining specific membrane properties, are just partially unravelled. Mitochondrial lipids are involved in organelle maintenance, fission and fusion, mitophagy and cytochrome c‐mediated apoptosis. Mutations in TAZ, SERAC1 and AGK affect mitochondrial phospholipid metabolism and cause Barth syndrome, MEGDEL and Sengers syndrome, respectively. In these disorders an abnormal mitochondrial energy metabolism was found, which seems to be due to disturbed protein‐lipid interactions #Affecting especially enzymes of the oxidative phosphorylation. Since a growing number of enzymes and transport processes are recognised as parts of the mitochondrial lipid metabolism, a further increase of lipid‐related disorders can be expected.
Developing a leadership pipeline: the Cleveland Clinic experience
Authors: Hess Caryl A. , Barss Christina , Stoller James K. 
Published: July 2014

The complexity of health care requires excellent leadership to address the challenges of access, quality, and cost of care. Because competencies to lead differ from clinical or research skills, there is a compelling need to develop leaders and create a talent pipeline, perhaps especially in physician-led organizations like Cleveland Clinic. In this context, we previously reported on a cohort-based physician leadership development course called Leading in Health Care and, in the current report, detail an expanded health care leadership development programme called the Cleveland Clinic Academy (CCA). CCA consists of a broad suite of offerings, including cohort-based learning and ‘a la carte’ half- or full-day courses addressing specific competencies to manage and to lead. Academy attendance is optional and is available to all physicians, nurses, and administrators with the requisite experience. Course selection is guided by competency matrices which map leadership competencies to specific courses. As of December 2012, a total of 285 course sessions have been offered to 6,050 attendees with uniformly high ratings of course quality and impact. During the past 10 years, Cleveland Clinic’s leadership and management curriculum has successfully created a pipeline of health care leaders to fill executive positions, search committees, board openings, and various other organizational leadership positions. Health care leadership can be taught and learned.
Pilot community‐mobilization program reduces maternal and perinatal mortality and prevents obstetric fistula in Niger
Authors: Seim Anders R. , Alassoum Zeidou , Bronzan Rachel N. , Mainassara Abderhamane Alou , Jacobsen Judith L. , Gali Yaroh Asma 
Published: July 2014

AbstractObjectiveTo assess the impact of a pilot community‐mobilization program on maternal and perinatal mortality and obstetric fistula in Niger.MethodsIn the program, village volunteers identify and evacuate women with protracted labor, provide education, and collect data on pregnancies, births, and deaths. These data were used to calculate the reduction in maternal mortality, perinatal mortality, and obstetric fistula in the program area from July 2008 to June 2011.ResultsThe birth‐related maternal mortality fell by 73.0% between years 1 and 3 (P < 0.001), from 630 (95% confidence interval [CI] 448–861) to 170 (95% CI 85–305) deaths per 100 000 births. Early perinatal mortality fell by 61.5% (P < 0.001), from 35 (95% CI 31–40) to 13 (95% CI 10–16) deaths per 1000 births. No deaths due to obstructed labor were reported after the lead‐in period (February to June 2008). Seven cases of community‐acquired fistula were reported between February 2008 and July 2009; from August 2009 to June 2011 (23 months; 12 254 births), no cases were recorded.ConclusionCommunity mobilization helped to prevent obstetric fistula and birth‐related deaths of women and infants in a large, remote, resource‐poor area.
On the wake dynamics of a propeller operating in drift
Authors: Di Mascio A. , Muscari R. , Dubbioso G. 
Published: July 2014

AbstractThe onset and the nature of dynamic instabilities experienced by the wake of a marine propeller set in oblique flow are investigated by means of detached eddy simulations. In particular, the destabilization process is inspected by a systematic comparison of the wake morphology of a propeller operating in pure axisymmetric flow and in drift with angle of 20°, under different loading conditions. The wake behaviour in oblique flow shows a markedly different character with respect to the axisymmetric condition: in the latter, the destabilization is triggered by an increasing interaction of the main vorticity confined in the tip vortex; whereas, in the former, the role of the secondary vorticity (oriented in the streamwise direction) as well as the hub vortex seems to be crucial. The features of the wake have been investigated by the$\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}\lambda _{2}$criterion (Jeong & Hussain,J. Fluid Mech., vol. 285, 1995, pp. 69–94) and typical flow variables (pressure, velocity and vorticity), for both the averaged and instantaneous flow fields. Moreover, in order to further inspect the evolution of the vortical structures, as well as their interaction and destabilization, the spectra of the kinetic energy have been considered. This investigation aims to broaden the knowledge from previous works on the subject of rotor wake instabilities, focusing on the differences between an ideal (axisymmetric) and actual operating conditions occurring in typical engineering applications.
The propagation of gravity currents in a V-shaped triangular cross-section channel: experiments and theory
Authors: Ungarish Marius , Mériaux Catherine A. , Kurz-Besson Cathy B. 
Published: July 2014

AbstractWe investigate the motion of high-Reynolds-number gravity currents (GCs) in a horizontal channel of V-shaped cross-section combining lock-exchange experiments and a theoretical model. While all previously published experiments in V-shaped channels were performed with the special configuration of the full-depth lock, we present the first part-depth experiment results. A fixed volume of saline, that was initially of length $\def \xmlpi #1{}\def \mathsfbi #1{\boldsymbol {\mathsf {#1}}}\let \le =\leqslant \let \leq =\leqslant \let \ge =\geqslant \let \geq =\geqslant \def \Pr {\mathit {Pr}}\def \Fr {\mathit {Fr}}\def \Rey {\mathit {Re}}x_0$ and height $h_0$ in a lock and embedded in water of height $H_0$ in a long tank, was released from rest and the propagation was recorded over a distance of typically $ 30 x_0$. In all of the tested cases the current displays a slumping stage of constant speed $u_N$ over a significant distance $x_S$, followed by a self-similar stage up to the distance $x_V$, where transition to the viscous regime occurs. The new data and insights of this study elucidate the influence of the height ratio $H = H_0/h_0$ and of the initial Reynolds number ${\mathit{Re}}_0 = (g^{\prime }h_0)^{{{1/2}}} h_0/ \nu $, on the motion of the triangular GC; $g^{\prime }$ and $\nu $ are the reduced gravity and kinematic viscosity coefficient, respectively. We demonstrate that the speed of propagation $u_N$ scaled with $(g^{\prime } h_0)^{{{1/2}}}$ increases with $H$, while $x_S$ decreases with $H$, and $x_V \sim [{\mathit{Re}}_0(h_0/x_0)]^{{4/9}}$. The initial propagation in the triangle is 50 % more rapid than in a standard flat-bottom channel under similar conditions. Comparisons with theoretical predictions show good qualitative agreements and fair quantitative agreement; the major discrepancy is an overpredicted $u_N$, similar to that observed in the standard flat bottom case.
Conservation assessment of the endemic plants of the Tuscan Archipelago, Italy
Authors: Foggi Bruno , Viciani Daniele , Baldini Riccardo M. , Carta Angelino , Guidi Tommaso 
Published: July 2014

AbstractThe Mediterranean islands support a rich diversity of flora, with a high percentage of endemic species. We used the IUCN categories and criteria to assess the conservation status of 16 endemic plant taxa (species and subspecies) of the Tuscan Archipelago, based on data collected during field surveys over 4 years. Our data were sufficient to use criteria B, C and D in our assessment. We used criterion B in the assessment of all 16 taxa, criterion C for four taxa, criterion D for 11 taxa and criteria B, C and D for three taxa, Centaurea gymnocarpa, Limonium doriae and Silene capraria. According to our results L. doriae, Romulea insularis and S. capraria are categorized as Critically Endangered and therefore require immediate conservation measures; eight taxa are categorized as Endangered, two as Vulnerable and three as Near Threatened. Compared to earlier assessments, eight species are recategorized with a higher degree of threat, two species are recategorized with a lower degree of threat, five are unchanged, and one species is assessed for the first time. Based on the IUCN categorization our results show that all the endemic species of the Tuscan Archipelago are directly and/or indirectly threatened by human activities, such as tourism and agriculture, and invasive species of plants and animals. The Tuscan Archipelago National Park is responsible for the conservation of all endemic species in the area.
Diagnosis of human fascioliasis by stool and blood techniques: update for the present global scenario
Authors: MAS-COMA S. , BARGUES M. D. , VALERO M. A. 
Published: July 2014

SUMMARYBefore the 1990s, human fascioliasis diagnosis focused on individual patients in hospitals or health centres. Case reports were mainly from developed countries and usually concerned isolated human infection in animal endemic areas. From the mid-1990s onwards, due to the progressive description of human endemic areas and human infection reports in developing countries, but also new knowledge on clinical manifestations and pathology, new situations, hitherto neglected, entered in the global scenario. Human fascioliasis has proved to be pronouncedly more heterogeneous than previously thought, including different transmission patterns and epidemiological situations. Stool and blood techniques, the main tools for diagnosis in humans, have been improved for both patient and survey diagnosis. Present availabilities for human diagnosis are reviewed focusing on advantages and weaknesses, sample management, egg differentiation, qualitative and quantitative diagnosis, antibody and antigen detection, post-treatment monitoring and post-control surveillance. Main conclusions refer to the pronounced difficulties of diagnosing fascioliasis in humans given the different infection phases and parasite migration capacities, clinical heterogeneity, immunological complexity, different epidemiological situations and transmission patterns, the lack of a diagnostic technique covering all needs and situations, and the advisability for a combined use of different techniques, at least including a stool technique and a blood technique.
Weddell seal foraging dives: comparison of free-ranging and isolated-hole paradigms
Authors: Madden K.M. , Fuiman L.A. , Williams T.M. , Davis R.W. 
Published: July 2014

AbstractWeddell seals are polar predators that must partition their time between many behaviours, including hunting prey at depth and breathing at the surface. Although they have been well studied, little is known about how foraging behaviour changes when access to breathing holes is restricted, such as in the isolated-hole paradigm. The current study took advantage of previously gathered data for seals diving at an isolated hole to compare with foraging behaviour of free-ranging seals that had access to multiple holes. We examined dive structure, hunting tactics, and allocation of time, locomotor activity and energy based on three-dimensional dive profiles and video imagery of prey encounters for two free-ranging and six isolated-hole seals. Midsummer foraging dives of free-ranging seals were remarkably similar to those of seals diving at an isolated hole, but there were differences in two behavioural states and the frequency of several behavioural transitions. Results indicate that seals employ an energetically more conservative foraging strategy when access to breathing holes is limited and prey are less abundant. These results highlight the importance of understanding the complex interactions between breathing hole access, prey abundance and other factors that may result in different Weddell seal foraging strategies under changing future conditions.
Differential effects of P2Y1 deletion on glial activation and survival of photoreceptors and amacrine cells in the ischemic mouse retina
Authors: Pannicke T , Frommherz I , Biedermann B , Wagner L , Sauer K , Ulbricht E , Härtig W , Krügel U , Ueberham U , Arendt T , Illes P , Bringmann A , Reichenbach A , Grosche A 
Published: July 2014

AbstractGliosis of retinal Müller glial cells may have both beneficial and detrimental effects on neurons. To investigate the role of purinergic signaling in ischemia-induced reactive gliosis, transient retinal ischemia was evoked by elevation of the intraocular pressure in wild-type (Wt) mice and in mice deficient in the glia-specific nucleotide receptor P2Y1 (P2Y1 receptor-deficient (P2Y1R-KO)). While control retinae of P2Y1R-KO mice displayed reduced cell numbers in the ganglion cell and inner nuclear layers, ischemia induced apoptotic death of cells in all retinal layers in both, Wt and P2Y1R-KO mice, but the damage especially on photoreceptors was more pronounced in retinae of P2Y1R-KO mice. In contrast, gene expression profiling and histological data suggest an increased survival of amacrine cells in the postischemic retina of P2Y1R-KO mice. Interestingly, measuring the ischemia-induced downregulation of inwardly rectifying potassium channel (Kir)-mediated K+ currents as an indicator, reactive Müller cell gliosis was found to be weaker in P2Y1R-KO (current amplitude decreased by 18%) than in Wt mice (decrease by 68%). The inner retina harbors those neurons generating action potentials, which strongly rely on an intact ion homeostasis. This may explain why especially these cells appear to benefit from the preserved Kir4.1 expression in Müller cells, which should allow them to keep up their function in the context of spatial buffering of potassium. Especially under ischemic conditions, maintenance of this Müller cell function may dampen cytotoxic neuronal hyperexcitation and subsequent neuronal cell loss. In sum, we found that purinergic signaling modulates the gliotic activation pattern of Müller glia and lack of P2Y1 has janus-faced effects. In the end, the differential effects of a disrupted P2Y1 signaling onto neuronal survival in the ischemic retina call the putative therapeutical use of P2Y1-antagonists into question.
Theobromine enhances absorption of cacao polyphenol in rats
Authors: Yamamoto Takayuki , Takahashi Haruya , Suzuki Koichiro , Hirano Akira , Kamei Masanori , Goto Tsuyoshi , Takahashi Nobuyuki , Kawada Teruo 
Published: July 2014

AbstractSeveral concentrations of theobromine (TB) and (−)-epicatechin (EC) were coadministered to rats, and plasma EC and its metabolites were determined using ultra-high-performance liquid chromatography–tandem mass spectrometry. It has been demonstrated that TB increases the absorption of EC in a dose-dependent manner. Cocoa powder had a similar effect, and the mechanism involved is not thought to depend on tight junctions.
Quantitative method for the assignment of hinge and shear mechanism in protein domain movements
Authors: Taylor Daniel , Cawley Gavin , Hayward Steven 
Published: July 2014

Abstract
Motivation: A popular method for classification of protein domain movements apportions them into two main types: those with a ‘hinge’ mechanism and those with a ‘shear’ mechanism. The intuitive assignment of domain movements to these classes has limited the number of domain movements that can be classified in this way. Furthermore, whether intended or not, the term ‘shear’ is often interpreted to mean a relative translation of the domains.
Results: Numbers of occurrences of four different types of residue contact changes between domains were optimally combined by logistic regression using the training set of domain movements intuitively classified as hinge and shear to produce a predictor for hinge and shear. This predictor was applied to give a 10-fold increase in the number of examples over the number previously available with a high degree of precision. It is shown that overall a relative translation of domains is rare, and that there is no difference between hinge and shear mechanisms in this respect. However, the shear set contains significantly more examples of domains having a relative twisting movement than the hinge set. The angle of rotation is also shown to be a good discriminator between the two mechanisms.
Availability and implementation: Results are free to browse at http://www.cmp.uea.ac.uk/dyndom/interface/ .
Contact: sjh@cmp.uea.ac.uk .
Supplementary information: Supplementary data are available at Bioinformatics online.