bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effectiveness and Efficiency of Nursing Care Documentation Using the SIMPRO Model
Authors: Hariyati Rr. Tutik Sri , Yani Achir , Eryando Tris , Hasibuan Zainal , Milanti Ariesta 
Published: March 2015

PurposeThe study aims to develop and test the effectiveness and efficiency of the SIMPRO. SIMPRO was developed with NANDA‐I, Nursing Intervention Classification, and Nursing Outcome Classification nursing language.MethodThe research was divided into two parts, in which we used two different designs—incremental and quasi‐experimental design. Two hundred fifty‐five samples of nursing documentations were randomly assessed with computer‐assisted clustering out of 1,040 nursing records of discharged patients. Data were analyzed using Wilcoxon test to compare each elements of evaluation before and after the implementation of the system.ResultSIMPRO improved the quality of documentation (p = .0001) and time efficiency (p = .0001).ConclusionSIMPRO increased the quality and functions of the decision support system in delivering nursing care as well as in nursing management.TujuanPenelitian ini bertujuan untuk mengembangkan dan menguji keefektifan dan efisiensi SIMPRO. SIMPRO adalah sistem informasi manajemen keperawatan yang dikembangkan dengan menggunakan NANDA‐I, Nursing Intervention Classification dan Nursing Outcome Classification.MetodePenelitian ini dibagi menjadi dua tahap yang menggunakan desain incremental dan kuasi‐eksperimental. 255 sampel dokumentasi keperawatan diambil secara acak dengan menggunakan klustering yang dibantu dengan komputer dari 1040 catatan keperawatan pasien yang sudah pulang. Data dianalisis dengan Uji Wilcoxon untuk membandingkan masing‐masing elemen sebelum dan sesudah implementasi sistem.HasilSIMPRO memperbaiki kualitas dokumentasi (p = .0001) dan efisiensi (p = .0001).KesimpulanSIMPRO meningkatkan kualitas dan fungsi sistem dukungan dalam memberikan asuhan keperawatan dan manajemen keperawatan.
The Public Health Responsibility deal: has a public–private partnership brought about action on alcohol reduction?
Authors: Knai Cécile , Petticrew Mark , Durand Mary Alison , Scott Courtney , James Lesley , Mehrotra Anushka , Eastmure Elizabeth , Mays Nicholas 
Published: March 2015

AbstractBackground and AimsThe Public Health Responsibility Deal (RD) in England is a public–private partnership involving voluntary pledges between industry, government and other organizations, with the aim of improving public health. This paper aims to evaluate what action resulted from the RD alcohol pledges.MethodsWe analysed publically available data on organizations’ plans and progress towards achieving key alcohol pledges of the RD. We assessed the extent to which activities pledged by signatories could have been brought about by the RD, as opposed to having happened anyway (the counterfactual), using a validated coding scheme designed for the purpose.ResultsProgress reports were submitted by 92% of signatories in 2013 and 75% of signatories in 2014, and provided mainly descriptive feedback rather than quantifiable performance metrics. Approximately 14% of 2014 progress reports were identical to those presented in 2013. Most organizations (65%) signed pledges that involved actions to which they appear to have been committed already, regardless of the RD. A small but influential group of alcohol producers and retailers reported taking measures to reduce alcohol units available for consumption in the market. However, where reported, these measures appear to involve launching and promoting new lower‐alcohol products rather than removing units from existing products.ConclusionsThe RD is unlikely to have contributed significantly to reducing alcohol consumption, as most alcohol pledge signatories appear to have committed to actions that they would have undertaken anyway, regardless of the RD. Irrespective of this, there is considerable scope to improve the clarity of progress reports and reduce the variability of metrics provided by RD pledge signatories.
Convergent grazing responses of different‐sized ungulates to low forage quality in a wet savanna
Authors: Stähli Annette , Edwards Peter J. , Olde Venterink Harry , Suter Werner 
Published: March 2015

AbstractWe studied how grazing intensity by small and mid‐sized ungulate grazers varied with nutritional quality and grass species composition in wet oligotrophic tallgrass savanna of coastal northern Tanzania. Average grazing intensity was low (3–15% by cover), and most grass species were scarcely used by herbivores. Only two grasses, Panicum infestum and Digitaria milanjiana, had nitrogen and phosphorus concentrations that were consistently above the minimum levels (e.g. nitrogen concentrations <7 mg g−1) required by the three commonest grazers, Bohor reedbuck, waterbuck and wildebeest. The best predictors of grazing intensity were cover of P. infestum (the most abundant grass, with a mean cover of 15%) and canopy height of ungrazed vegetation. Models did not contain separate predictors for nutritional quality, presumably because quality varied mainly at the grass species level and therefore was fully represented by the variable ‘cover of P. infestum’. Given that the three grazers differed greatly in body size and muzzle width (parameters known to influence nutrient requirements and the ability of grazers to feed selectively at the smallest spatial scale), we expected there to be strong resource partitioning that would be detectable in terms of grazing strategies and feeding sites. However, apart from minor differences in canopy height, greenness and diameter of grazed patches (albeit consistent with our expectations), feeding stations of the three grazers were similar and strongly dominated by P. infestum. We conclude that the low quality of herbage in wet oligotrophic savannas restricts foraging choices, which produces a characteristic yet impoverished grazing community that exhibits only limited resource partitioning.
Addisonian crisis in a dog treated with phenobarbitone
Authors: Simerdova V , Hajek I , Schanilec P 
Published: March 2015

BackgroundA 2‐year‐old intact female Irish Setter was presented with a 1‐week history of anorexia, lethargy, vomiting and diarrhoea. Previous medical therapy included a 3‐week treatment with phenobarbitone for suspected idiopathic epilepsy. In humans, phenobarbitone accelerates metabolism of both exogenous and endogenous steroids.Case reportBased on history, the physical examination showing abnormal mentation and laboratory abnormalities including azotaemia, hyponatraemia and hyperkalaemia, Addisonian crisis was suspected. An adrenocorticotropic hormone stimulation test was performed and confirmed the diagnosis. Treatment with intravenous fluid therapy, glucocorticoids and mineralocorticoids led to a resolution of clinical signs in 3 days.ConclusionTo the authors' current knowledge, this is the first reported case of Addisonian crisis in a dog most probably related to phenobarbitone administration. As Addisonian crisis can be life‐threatening, clinicians should be aware of this adverse effect of phenobarbitone and use it cautiously in dogs with borderline hypoadrenocorticism.
Busulfan dosing algorithm and sampling strategy in stem cell transplantation patients
Authors: de Castro Francine A. , Piana Chiara , Simões Belinda P. , Lanchote Vera L. , Della Pasqua O. 
Published: March 2015

AimThe aim of this investigation was to develop a model‐based dosing algorithm for busulfan and identify an optimal sampling scheme for use in routine clinical practice.MethodsClinical data from an ongoing study (n= 29) in stem cell transplantation patients were used for the purposes our analysis. A one compartment model was selected as basis for sampling optimization and subsequent evaluation of a suitable dosing algorithm. Internal and external model validation procedures were performed prior to the optimization steps using ED‐optimality criteria. Using systemic exposure as parameter of interest, dosing algorithms were considered for individual patients with the scope of minimizing the deviation from target range as determined by AUC(0,6 h).ResultsBusulfan exposure after oral administration was best predicted after the inclusion of adjusted ideal body weight and alanine transferase as covariates on clearance. Population parameter estimates were 3.98 h–1, 48.8 l and 12.3 l h–1for the absorption rate constant, volume of distribution and oral clearance, respectively. Inter‐occasion variability was used to describe the differences between test dose and treatment. Based on simulation scenarios, a dosing algorithm was identified, which ensures target exposure values are attained after a test dose. Moreover, our findings show that a sparse sampling scheme with five samples per patient is sufficient to characterize the pharmacokinetics of busulfan in individual patients.ConclusionThe use of the proposed dosing algorithm in conjunction with a sparse sampling scheme may contribute to considerable improvement in the safety and efficacy profile of patients undergoing treatment for stem cell transplantation.
4,4′‐DMAR: Chemistry, Pharmacology and Toxicology of a New Synthetic Stimulant of Abuse
Authors: Coppola Maurizio , Mondola Raffaella 
Published: March 2015

AbstractIn recent years, the spread of new psychoactive substances has dramatically increased in term of availability of both number of compounds and chemical families. In November 2012, 4,4′‐Dimethylaminorex (4,4′‐DMAR), a novel synthetic stimulant, was first detected in the Netherlands. Between June 2013 and June 2014, thirty‐one deaths associated with the consumption of this new drug have been registered across Europe. In this MiniReview, we have summarized the chemical, pharmacological and toxicological information about this new legal high.
In the eyes of the beholder: Understanding subtypes of social withdrawal among young Chinese children
Authors: Cheah Charissa S. L. , Xu Yiyuan 
Published: March 2015

In this commentary on Ding et al. (Brit. J. Dev. Psychol., 2015; 33, 159–173), we focus on the following: (1) the authors’ use of vignettes portraying various prototypes of withdrawn children and (2) the cultural interpretation of their findings. We end with some suggestions for future research.
Treosulfan‐based conditioning regimen for allogeneic haematopoietic stem cell transplantation in children with sickle cell disease
Authors: Strocchio Luisa , Zecca Marco , Comoli Patrizia , Mina Tommaso , Giorgiani Giovanna , Giraldi Eugenia , Vinti Luciana , Merli Pietro , Regazzi Mario , Locatelli Franco 
Published: March 2015

SummaryAlthough allogeneic haematopoietic stem cell transplantation (HSCT) still represents the only consolidated possibility of cure for sickle cell disease (SCD) patients, its use has been limited by the risk of morbidity and mortality associated with conventional myeloablative therapy. The introduction of treosulfan to replace busulfan in conditioning regimens has recently been explored by virtue of its lower toxicity profile. We report our experience with a treosulfan/thiotepa/fludarabine conditioning for human leucocyte antigen (HLA)‐matched sibling or unrelated donor‐HSCT in 15 children with SCD, and compare patient outcomes with those of a historical cohort (15 patients) given a busulfan‐based regimen. Engraftment was achieved in 28 out of 30 patients (93%), with one case of graft failure in either group. The conditioning regimen was well tolerated in both groups, with no cases of grade III‐IV regimen‐related toxicity. The 7‐year overall survival (OS) and disease‐free survival (DFS) for the whole cohort were 100% and 93%, respectively, with a 93% DFS in both busulfan and treosulfan groups. No SCD‐related adverse events occurred after engraftment in patients with complete or mixed donor chimerism. This retrospective analysis suggests that a treosulfan‐based conditioning regimen is able to ensure engraftment with excellent OS/DFS and low regimen‐related toxicity in patients with SCD.
Symptoms, unmet needs, psychological well‐being and health status in survivors of prostate cancer: implications for redesigning follow‐up
Authors: Watson Eila , Shinkins Bethany , Frith Emma , Neal David , Hamdy Freddie , Walter Fiona , Weller David , Wilkinson Clare , Faithfull Sara , Wolstenholme Jane , Sooriakumaran Prasanna , Kastner Christof , Campbell Christine , Neal Richard , Butcher Hugh , Matthews Mike , Perera Rafael , Rose Peter 
Published: March 2015

ObjectiveTo explore ongoing symptoms, unmet needs, psychological wellbeing, self‐efficacy and overall health status in survivors of prostate cancer.Patients and MethodsAn invitation to participate in a postal questionnaire survey was sent to 546 men, diagnosed with prostate cancer 9–24 months previously at two UK cancer centres. The study group comprised men who had been subject to a range of treatments: surgery, radiotherapy, hormone therapy and active surveillance. The questionnaire included measures of prostate‐related quality of life (Expanded Prostate cancer Index Composite 26‐item version, EPIC‐26); unmet needs (Supportive Care Needs Survey 34‐item version, SCNS‐SF34); anxiety and depression (Hospital Anxiety and Depression Scale, HADS), self‐efficacy (modified Self‐efficacy Scale), health status (EuroQol 5D, EQ‐5D) and satisfaction with care (questions developed for this study). A single reminder was sent to non‐responders after 3 weeks. Data were analysed by age, co‐morbidities, and treatment group.ResultsIn all, 316 men completed questionnaires (64.1% response rate). Overall satisfaction with follow‐up care was high, but was lower for psychosocial than physical aspects of care. Urinary, bowel, and sexual functioning was reported as a moderate/big problem in the last month for 15.2% (n = 48), 5.1% (n = 16), and 36.5% (n = 105) men, respectively. The most commonly reported moderate/high unmet needs related to changes in sexual feelings/relationships, managing fear of recurrence/uncertainty, and concerns about the worries of significant others. It was found that 17% of men (51/307) reported potentially moderate‐to‐severe levels of anxiety and 10.2% (32/308) reported moderate‐to‐severe levels of depression. The presence of problematic side‐effects was associated with higher psychological morbidity, poorer self‐efficacy, greater unmet needs, and poorer overall health status.ConclusionWhile some men report relatively few problems after prostate cancer treatment, this study highlights important physical and psycho‐social issues for a significant minority of survivors of prostate cancer. Strategies for identifying those men with on‐going problems, alongside new interventions and models of care, tailored to individual needs, are needed to improve quality of life.
Differential cytokine expression detected by protein microarray screening in peripheral blood of patients with refractory Graves' disease
Authors: Song Rong‐hua , Qin Qiu , Wang Xuan , Yan Ni , Meng Shuai , Shi Xiao‐hong , He Shuang‐tao , Zhang Jin‐an 
Published: March 2015

SummaryObjectiveThe prognosis of Graves' disease (GD) varies among patients. However, the immune pathogenesis of refractory GD is still unknown. The aim of this study was to explore the cytokine expression profile associated with refractory GD.MethodsPreliminary cytokine protein microarray screening was performed to detect differentially expressed cytokines in the plasma of four patients with refractory GD and four patients with stable GD. Some differentially expressed cytokines were then validated in plasma by enzyme‐linked immunosorbent assay (ELISA) and in peripheral blood mononuclear cells (PBMCs) by quantitative real‐time polymerase chain reaction (qRT‐PCR) on another independent set of samples.ResultsWe found that 21 cytokines were differentially expressed between patients with intractable GD and those in remission, including 18 upregulated and 3 downregulated cytokines with a fold change >1·30 and <0·77, respectively. Intractability‐related elevation of three cytokines (IL‐4, IL‐6 and IL‐10) was validated by ELISA in plasma on another GD cohort with 30 patients in recurrence and 14 in remission (t‐test, P = 0·035, 0·033 and 0·041, respectively). Furthermore, mRNA expression of IL‐4, IL‐6 and IL‐10 in PBMCs, detected by qRT‐PCR, was significantly elevated in patients with refractory GD compared with those in remission (P = 0·039, 0·047 and 0·042, respectively).ConclusionThe severity of GD is associated with the aberrant expression and secretion of several cytokines that may serve as potential biomarkers and predictors for disease prognosis. Targeting these cytokines or their receptors may also lead to a novel therapeutic intervention for GD.
Human fetal osteoblast behavior on zirconia dental implants and zirconia disks with microstructured surfaces. An experimentalin vitrostudy
Authors: Delgado‐Ruíz Rafael Arcesio , Gomez Moreno Gerardo , Aguilar‐Salvatierra Antonio , Markovic Aleksa , Mate‐Sánchez Jose Eduardo , Calvo‐Guirado José Luis 
Published: March 2015

AbstractObjectivesTo measure the lateral surface area of microgrooved zirconia implants, to evaluate the cell geometry and cell density of human fetal osteoblasts seeded on zirconia microgrooved implants, to describe the surface roughness and chemistry, and to evaluate the activity of human fetal osteoblasts seeded on zirconia microgrooved disks.Materials and methodsThis experimentalin vitrostudy used 62 zirconia implants and 130 zirconia disks. Two experimental groups were created for the implants: 31 non‐microgrooved implants (Control) and 31 microgrooved implants (Test); two experimental groups were created for the disks: 65 non‐microgrooved disks (Control) and 65 microgrooved disks (Test). The following evaluations of the implants were made: lateral surface area (LSA), cell morphology, and density of human fetal osteoblasts seeded on implant surfaces. On the disks, surface parameters (roughness and chemistry) and cell activity (alkaline phosphatase –ALPand alizarin red –ALZ) were evaluated at 7 and 15 days.ResultsLSAwas lower for control implants (62.8 mm) compared with test implants (128.74 mm) (P < 0.05). Cell bodies on control surfaces were flattened and disorganized, while in the test group, they were aligned inside the microgrooves. Control group cells showed few lamellipodia, which were attached mainly inside topographical accidents (surface cracks, valleys, and pits). Test group implants presented cells rich in lamellipodia prolongations, attached to the inner walls or to the borders of the microgrooves and in the flat areas between the microgrooves. Cell density was higher in the test group compared with controls (P < 0.05) Surface roughness and oxygen content increased in test disks samples compared with controls (P < 0.05). Carbon and aluminum were reduced in disks test samples compared with controls (P < 0.05), andALPandALZlevels were significantly increased on test surfaces (P < 0.05) at both study times.ConclusionsWithin the limitations of this experimental study, it may be concluded that (i) Roughness is increased and chemical composition enhanced on the surface of zirconia implants with microgrooves. (ii) TheLSAof microgrooved zirconia implants is greater and provides more available surface compared with implants of the same dimensions without microgrooves. (iii) Microgrooves on zirconia implants modify the morphology and guide the size and alignment of human fetal osteoblasts. (iv) Zirconia surfaces with microgrooves of 30 μm width and 70 μm separation between grooves enhanceALPandALZexpression by human fetal osteoblasts.
Neuropsychological and Neuroimaging Characteristics of Amnestic Mild Cognitive Impairment Subtypes: A Selective Overview
Authors: Li Xin , Zhang Zhan‐Jun 
Published: March 2015

SummaryAlzheimer's disease (AD) is a progressive age‐related neurodegenerative disease. Amnestic mild cognitive impairment (aMCI) is considered to represent early AD. Various aMCI clinical subtypes have been identified as either single domain (SD) or multidomain (MD). The various subtypes represent heterogeneous syndrome, indicating the different probability of progression to AD. Understanding the heterogeneous concept of aMCI can help to construct potential biomarkers to monitor the progression of aMCI to AD. This review provides an overview of various neuroimaging measures for subtypes of aMCI. Focusing on neuropsychological, structural, and functional neuroimaging findings, we found that aMCI showed differences in clinical progression and the abnormalities in MD‐aMCI were distributed across temporal, frontal, and parietal cortices, which is similar to AD. This is also compatible with the notion that MD‐aMCI is a transition stage between SD‐aMCI and AD. Our review provided a framework for the diagnosis of clinical subtypes of aMCI and early detection and intervention of the progression from aMCI to AD.
Clarifying the effect of behavioral and clinical factors on traumatic dental injuries in childhood: a hierarchical approach
Authors: Kramer Paulo Floriani , Feldens Eliane Gerson , Bruch Cristina Montini , Ferreira Simone Helena , Feldens Carlos Alberto 
Published: March 2015

AbstractAimTo explore associations between traumatic dental injuries (TDI) in Brazilian preschool children and clinical, behavioral, and socio‐demographic factors using a hierarchical approach.Material and MethodsA cross‐sectional study was conducted involving 1316 children aged 0–5 years at public preschools in the city of Canoas (southern Brazil). Demographic (sex and age), socioeconomic (mother's schooling, income and family structure) and behavioral (use of pacifier, breastfeeding duration and bottle use at 12 months) factors were collected through a questionnaire. TDI (Andreasen criteria) and malocclusion (overjet and anterior open bite) were recorded by trained and calibrated examiners. Poisson regression was employed to determine factors associated with TDI using a hierarchical approach.ResultsThe prevalence of TDI was 13.3%. In the final model, the probability of TDI was 50% higher in children who used a pacifier (PR: 1.50; 95% CI: 1.08–2.10), 77% higher in children with overjet between 3 and 5 mm (PR: 1.77; 95% CI: 1.22–2.57) and nearly threefold higher in children with overjet > 5 mm (PR: 2.73; 95% CI: 1.77–4.20) compared with children with overjet ≤ 2 mm. Additional analysis demonstrated that overjet represented the pathway by which pacifier use was associated with TDI.ConclusionPacifier use is strongly associated with the occurrence of TDI in the primary dentition, and accentuated overjet represents a pathway to this association. These findings suggest the need for prevention strategies that address early counseling on pacifier use to reduce the occurrence of TDI.