bluuebunny/crossref_metadata_2025_split huggingface dataset:
Obliteration of the choroid plexus after endoscopic coagulation
Authors: Ogiwara Hideki , Uematsu Kodai , Morota Nobuhito 
Published: July 2014

Object
Endoscopic choroid plexus coagulation (CPC) with or without endoscopic third ventriculostomy (ETV) has been shown to be effective for selected patients with hydrocephalus. However, whether the effect of the coagulation is temporary and the choroid plexus regenerates or can be obliterated has remained largely unknown. The authors evaluate the effectiveness of CPC and report 3 cases of obliteration demonstrated by direct endoscopic observation.

Methods
The authors retrospectively analyzed the surgical results of patients with hydrocephalus primarily treated by CPC with or without ETV. Charts were reviewed for demographic data, clinical presentations, surgical therapies, and clinical outcomes.

Results
Eighteen patients with hydrocephalus were surgically treated using endoscopic CPC between July 2002 and July 2012. In 12 patients, ETV was concurrently performed. The etiology of hydrocephalus was posthemorrhagic in 5 patients, myelomeningocele in 3, postmeningitis in 2, congenital aqueductal stenosis in 1, hydranencephaly in 1, porencephaly in 1, and idiopathic in 5.
The mean age at surgery was 8 months (range 0.3–24 months). The mean follow-up was 64 months. In 9 cases (50%), control of hydrocephalus was successful and the patients did not require further surgeries. In 9 patients (50%), treatment failed. Of these, 3 patients underwent repeat ETV 2, 3, and 38 months after the initial surgery. Endoscopic observation of the previous coagulation site revealed no regeneration of the choroid plexus in 2 patients, who underwent repeat ETV 2 and 3 months after CPC. In 1 patient who underwent repeat ETV 38 months after CPC, no regeneration of the choroid plexus, except for that in the proximity of the foramen of Monro, was observed.

Conclusions
Endoscopic CPC with or without ETV can be a safe and effective treatment alternative to shunt placement in infantile hydrocephalus. Obliteration of the choroid plexus can persist in the relatively long term following CPC, which may contribute to the long-term control of hydrocephalus in successful cases.
Investigating Recurrent Neural Networks for OCT A-scan Based Tissue Analysis
Authors: Otte S. , Wittig L. , Hüttmann G. , Kugler C. , Drömann D. , Zell A. , Schlaefer A. , Otte C. 
Published: July 2014

Summary
Objectives: Optical Coherence Tomography (OCT) has been proposed as a high resolution image modality to guide transbronchial biopsies. In this study we address the question, whether individual A-scans obtained in needle direction can contribute to the identification of pulmonary nodules.
Methods: OCT A-scans from freshly resected human lung tissue specimen were recorded through a customized needle with an embedded optical fiber. Bidirectional Long Short Term Memory networks (BLSTMs) were trained on randomly distributed training and test sets of the acquired A-scans. Patient specific training and different pre-processing steps were evaluated.
Results: Classification rates from 67.5% up to 76% were archived for different training scenarios. Sensitivity and specificity were highest for a patient specific training with 0.87 and 0.85. Low pass filtering decreased the accuracy from 73.2% on a reference distribution to 62.2% for higher cutoff frequencies and to 56% for lower cutoff frequencies.
Conclusion: The results indicate that a grey value based classification is feasible and may provide additional information for diagnosis and navigation. Furthermore, the experiments show patient specific signal properties and indicate that the lower and upper parts of the frequency spectrum contribute to the classification.
Simulation of Range Imaging-based Estimation of Respiratory Lung Motion
Authors: Werner R. , Blendowski M. , Ortmüller J. , Handels H. , Wilms M. 
Published: July 2014

SummaryObjectives: A major problem associated with the irradiation of thoracic and abdominal tumors is respiratory motion. In clinical practice, motion compensation approaches are frequently steered by low-dimensional breathing signals (e.g., spirometry) and patient-specific correspondence models, which are used to estimate the sought internal motion given a signal measurement. Recently, the use of multidimensional signals derived from range images of the moving skin surface has been proposed to better account for complex motion patterns. In this work, a simulation study is carried out to investigate the motion estimation accuracy of such multidimensional signals and the influence of noise, the signal dimensionality, and different sampling patterns (points, lines, regions).Methods: A diffeomorphic correspondence modeling framework is employed to relate multidimensional breathing signals derived from simulated range images to internal motion patterns represented by diffeomorphic non-linear transformations. Furthermore, an automatic approach for the selection of optimal signal combinations/patterns within this framework is presented.Results: This simulation study focuses on lung motion estimation and is based on 28 4D CT data sets. The results show that the use of multidimensional signals instead of one-dimensional signals significantly improves the motion estimation accuracy, which is, however, highly affected by noise. Only small differences exist between different multidimensional sampling patterns (lines and regions). Automatically determined optimal combinations of points and lines do not lead to accuracy improvements compared to results obtained by using all points or lines.Conclusions: Our results show the potential of multidimensional breathing signals derived from range images for the model-based estimation of respiratory motion in radiation therapy.
A Bridge Health Monitoring System Based on Wireless Smart Aggregates
Authors: Yan Shi , Ma Hao Yan , Jiang Xue Lei , Qi Bao Hui , Liu Fu Xue 
Published: July 2014

Researches on health monitoring technology of concrete structures by using piezoelectric smart aggregates have achieved a great development. However, the technique is not widely used so far in practical engineering. Because when constructing large-scale structural health monitoring (SHM) system using wire-based sensors, it requires a lot of cables to form a monitoring network, resulting in huge cost of abundant material of wires and labor for wire placement, and the relatively heavy maintenance work in case of failure of the SHM system. A kind of wireless sensor network based on the protocol for Zigbee802.15.4 and the passive piezoelectric smart health monitoring technology is developed in the paper. Through internal load monitoring tests of a concrete bridge model under impact loading, the developed wireless smart aggregate (WSA) health monitoring system is experimentally validated. The finite element method (FEM) is used to simulate the process as the same as the bridge model test, and the numerical results are consistent with those of the experiment. The experimental results show that the developed wireless system is stable and reliable, and can be applied in concrete bridge structure health monitoring under impact loading.
Analysis of Wind-Induced Vibration Response for a Long-Span Double-Arch-Support Steel Structure
Authors: Chen Lan , Yin Bo , Huang Zhi Guang 
Published: July 2014

As a new long-span double-arch-support steel structure system is applied to a stadium, it is necessary to study the wind-induced vibration response of the roof structure to meet the need of design. The modal analysis and the response analyses which include static wind response and wind-induced vibration response are calculated by ANSYS. The results show that the natural vibration frequency of structure is intensive (0.93 Hz~4.2 Hz). The most unfavorable wind direction angle of 135o is selected to study the wind-induced vibration response. And the wind-induced vibration coefficient calculated is satisfactory when compared with the wind tunnel test. It can be seen that it is feasible to use the stochastic simulation analysis method of wind-induced vibration response to get the wind-induced vibration coefficient.
Seismic Performance of the Reinforced Concrete Frame Structures with Infilled Walls of Different Configuration
Authors: Guan Min Sheng , Du Hong Biao , Chen Wei , Wu Yu Hua 
Published: July 2014

Using the three-strut model, five types of frame structures, i.e., without infilled walls, with full infilled walls, without bottom-storey infilled walls, without middle-storey infilled walls and without top-storey infilled walls, were studied. The mode analysis and nonlinear time-history analysis were carried out on each model. In order to investigate the effects of infilled walls with different configurations on the seismic behavior of reinforced concrete frame structures, the structural periods, the ratio of Tt to T1 and the maximum interstorey drifts were analyzed. The results indicate that the infilled walls enhance the lateral stiffness of frames, and the configuration of infilled walls has little influence on the calculation of structural periods. It also shows that the weaker storey is formed due to the unreasonable layout of infilled walls, thus leading to the collapse of the whole structures under the seismic action.
Nigerian teachers’ perception of barriers to technology integration into the chemistry instructions
Authors: Okanlawon AE 
Published: July 2014

This paper documents chemistry teachers’ perceptions of barriers to technology integration into the chemistry lessons. Underlying the study was a conceptual underpinning which focused on the concept of ICT integration, competencies of integration and chemistry curriculum. 13 participants were recruited for the study. Their participation in this research is voluntary. Semi-structured, open-ended interviews were employed as the means for collecting decontextualized statements about barriers to technology integration. The pool of statements obtained was subjected to phenomenographic analysis. A limited number of qualitatively different perceptions of barriers to technology integration were identified as: lack of teacher training, lack of technical support, limited time for teacher planning, computer placement in remote locations making access difficult, budget constraints and basic resistance to change by many teachers. The discussion and implications sections of the paper explore the issues on barriers to ICT integration chemistry instructions in greater depth by pointing out the multifaceted relationship among the barriers as well as recommending ways of overcoming the identified barriers.Key words: Chemistry curriculum, technology integration, pedagogical competencies, technological competencies, teacher perceptions.
The Flexible Party Gums: An Esthetic Alternative for Lost Gingiva
Authors: Dange Shankar , Agrawal Trupti Rajendra , Khalikar Smita 
Published: July 2014

ABSTRACT
One of the most important parts of an ideal smile is the presence of healthy gingiva. Healthy gingival tissues affect the esthetics, probably much more than teeth, a factor which is most often neglected in esthetic treatment planning. Periodontal flap surgeries often leave open embrasure spaces which are a huge esthetic deficit for the patient. Replacing the missing gingival tissue with composite, ceramic, acrylic or silicone has been reported in the literature. This case report describes the use of a gingival prosthesis fabricated by valplast-a flexible nylon- based material to recreate the lost soft tissue esthetics.

How to cite this article
Agrawal TR, Dange S, Khalikar S. The Flexible Party Gums: An Esthetic Alternative for Lost Gingiva. Int J Prosthodont Restor Dent 2014;4(1):20-22.
Three-dimensional Imaging in Implant Assessment for the Prosthodontist: Utilization of the Cone Beam Computed Tomography
Authors: Raju Minu , Rodrigues Shobha J , Mundathaje Mahesh , Qureshi Sabaa 
Published: July 2014

ABSTRACT

Background
The evolution of cone beam computed tomo- graphy three-dimensional (CBCT 3D) imaging has dramatically changed the potential for presurgical and pretreatment planning, such that outcomes are more predictable and complications more avoidable.

Purpose
The purpose of this article was to systematically review scientific and clinical literature pertaining to the uses and benefits of 3D imaging CBCT for diagnosis and treatment planning in Implantology including prosthodontics.

Materials and methods
Various databases, like PubMed, EBSCOhost and ScienceDirect, were searched from 1998 to 2010 to retrieve articles regarding the clinical applications of CBCT in dentistry. Cone beam computed tomography in dentistry was used as a key phrase to extract relevant articles in dentistry. A manual search for the references from the retrieved articles was also completed. The articles published only in English, randomized clinical trials, prospective and retrospective clinical studies, laboratory and computer-generated research were included.
The search revealed 540 articles of which 447 were irrele- vant to the study and therefore excluded.

Results
Cone beam computed tomography has created an opportunity for clinicians to acquire the highest quality diagno- stic images with an absorbed dose that is comparable to other dental radiological examinations and less than a conventional CT. Therefore, if placement of an implant might approach a nerve, invade the sinus, or penetrate out of the confines of the jawbone, the patient should be offered a discussion of CBCT 3D imaging. In addition, CBCT 3D patients should be advised of the risks, benefits and alternatives to such treatment, based upon any additional data provided by the imaging.

How to cite this article
Rodrigues SJ, Mundathaje M, Raju M, Qureshi S. Three-dimensional Imaging in Implant Assessment for the Prosthodontist: Utilization of the Cone Beam Computed Tomography. Int J Prosthodont Restor Dent 2014;4(1):23-33.
Eficácia de mobiliário escolar adaptado de baixo custo no desempenho funcional de criança com paralisia cerebral
Authors: Piovezanni Marco Aurélio Teixeira , Rocha Aila Narane Dahwache Criado , Braccialli Lígia Maria Presumido 
Published: July 2014

http://dx.doi.org/10.5902/1984686X7289 Indivíduos com Paralisia Cerebral apresentam desenvolvimento motor atípico, caracterizado por alterações posturais, de coordenação motora e de tônus muscular, que resulta em limitações no desempenho de atividades funcionais. Neste contexto destaca-se a prescrição e confecção de recursos de tecnologia assistiva com objetivo de maximizar as habilidades funcionais destas pessoas e prover sua inclusão social. Os indivíduos com paralisia cerebral, muitas vezes, têm dificuldade para a manutenção da dinâmica corporal, principalmente na postura sentada. O objetivo deste estudo foi o de confeccionar uma cadeira e mesa escolar adaptadas com material de baixo custo e verificar sua eficácia no desempenho grafomotor de uma criança com paralisia cerebral. O participante foi uma criança com diagnóstico de paralisia cerebral diplégica, do gênero masculino. A coleta e registro dos dados foram feitos em três momentos, com a criança posicionada no mobiliário adaptado, no mobiliário escolar comum e novamente no mobiliário adaptado, para se estabelecer a comparação. A análise de dados se deu por meio de testes estatísticos não paramétricos. Não houve significância estatística e foi verificada uma inconstância nos dados apresentados, já que não se pode afirmar ao certo qual mobiliário foi mais eficaz na realização da atividade proposta e nem se houve aprendizado motor com a sua repetição. Esse fato não invalida a adequação de mobiliário escolar ao aluno com paralisia cerebral, visto que este é um fator importante para favorecer o controle e estabilidade postural ao individuo, o que interfere na coordenação motora fina destes indivíduos, influenciando no seu desempenho em atividades escolares. Palavras - chave: Educação especial. Tecnologia assistiva. Mobiliário escolar.
Financial Burden of Dental Care Among Patients With Head and Neck Cancer
Authors: Ben Dor Betty , Villa Alessandro , Hayes Catherine , Alpert Elizabeth , Shepard Donald S. , Sonis Stephen T. 
Published: August 2024

ImportancePatients undergoing treatment for head and neck cancer (HNC) experience oral complications requiring substantial dental treatment. This treatment is commonly not reimbursed by medical insurers, presenting a potential financial burden for patients.ObjectiveTo characterize the dental care needs and associated cost burden for patients with HNC.Design, Setting, and ParticipantsThis survey study included Head and Neck Cancer Alliance (HNCA) members who were surveyed from March 23 to October 27, 2023, using Qualtrics. The survey was promoted using the HNCA’s social media and email list. Data analysis was performed between October 2023 and May 2024.Main Outcomes and MeasuresMain outcomes were oral and dental complications of cancer treatment among patients with HNC, the association of cancer treatment with dental care use, and costs of associated dental treatment.ResultsOf 100 individuals administered the survey, 85 (85%) completed all required questions and were included in the analysis. Of 84 participants with age and sex data, 51 (61%) were aged 65 years or older and 45 (54%) were female. Of 85 respondents, 59 (70%) indicated that their current oral health was worse than before cancer treatment. Most respondents (73 of 85 [86%]) endorsed oral complications from cancer treatment, including xerostomia (66 of 73 [90%]), caries (35 of 73 [48%]), and oral mucositis (29 of 73 [40%]); 64 of 73 respondents (88%) required follow-up dental treatment. Overall, 4 of 28 (14%) before HNC treatment and 17 of 53 (32%) after treatment reported finances as the reason that not all recommended dental care was received. A total of 33 of the 85 respondents (39%) said that their postcancer dental care had caused them financial hardship. Individuals who were less likely to endorse financial hardship were more likely to have greater educational attainment (odds ratio [OR], 0.20; 95% CI, 0.06-0.58), higher income (OR, 0.33; 95% CI, 0.11-0.94), increased pre-HNC dental visit frequency (OR, 0.30; 95% CI, 0.10-0.86), same or better oral health after HNC (OR, 0.13; 95% CI, 0.02-0.50), and lower out-of-pocket dental expenses after HNC (OR, 0.09; 95% CI, 0.03-0.29).Conclusions and RelevanceIn this survey study, most patients undergoing treatment for HNC required extensive dental treatment throughout cancer treatment; this treatment presented a financial burden for 39% of patients that was a limiting barrier to care. Since most private medical insurers do not reimburse for dental treatment, more comprehensive coverage deserves policy attention.
Synthesis of 4‐Phenylpyrrolidin‐2‐one
via
an Aza‐Baeyer‐Villiger Rearrangement
Authors: Ong Mike , Arnold Marlene , Wahl Johannes M. 
Published: August 2024

Abstract
This chapter presents the procedure for synthesis of 4‐phenylpyrrolidin‐2‐one via an aza‐Baeyer‐Villiger rearrangement. The synthesis of γ‐lactams represents a critical area of current research, because these compounds have been identified as promising scaffolds for the development of new drugs due to their diverse and often potent biological activities. Facile access to γ‐lactam analogues provides a platform to explore structure activity relationships enabling the development of novel therapeutic agents. Insertion of a nitrogen group in the α‐position of a carbonyl is well established by the Schmidt and Beckmann reactions. However, these procedures often entail harsh reaction conditions rendering them less suitable for late‐stage transformations and lowering the functional group compatibility. A mechanistic investigation unveiled rearrangement from a Criegee‐like intermediate via an aza‐Baeyer‐Villiger type reaction, a decisive contrast to the venerable Beckmann rearrangement.
Self‐Recoverable Symmetric Protonic Ceramic Fuel Cell with Smart Reversible Exsolution/Dissolution Electrode
Authors: Wang Yuhao , Wang Zheng , Yang Kaichuang , Liu Jiapeng , Song Yufei , Li Jingwei , Hu Zhiwei , Robson Matthew J. , Zhang Zhiqi , Tian Yunfeng , Xu Shenjun , Lu Ying , Law Ho Mei , Liu Feng , Chen Qing , Yang Zhibin , Ciucci Francesco 
Published: August 2024

AbstractThis study unveils a novel concept of symmetric protonic ceramic fuel cells (symm‐PCFCs) with the introduction of a self‐recoverable electrode design, employing the innovative material BaCo0.4Fe0.4Zr0.1Y0.1O3‐δ (BCFZY). This research marks a significant milestone as it demonstrates the bi‐functional electrocatalytic activity of BCFZY for the first time. Utilizing density functional theory simulations, the molecular orbital interactions and defect chemistry of BCFZY are explored, uncovering its unique capability for the reversible exsolution and dissolution of Co‐Fe nanoparticles under redox conditions. This feature is pivotal in promoting both hydrogen oxidation and oxygen reduction reactions. Leveraging this insight, a cell is fabricated exhibiting high electrocatalytic activity and fuel flexibility as evidenced by the peak power densities of ≈350, 287, and 221 mW cm−2 (at 600 °C) with hydrogen, methanol, and methane as fuels, respectively. Experiments also show that the reversible exsolution/dissolution mitigates performance degradation, enabling prolonged operational life through self‐recovery. This approach paves the way for novel, advanced, durable, and commercially viable symm‐PCFCs.
Engineered Zwitterionic Diblock Copolymer‐siRNA Polyplexes Provide Highly Effective Treatment of Triple‐Negative Breast Cancer in a 4T1 Murine Model
Authors: Jeon Taewon , Goswami Ritabrita , Nagaraj Harini , Cicek Yagiz Anil , Lehot Victor , Welton Janelle , Bell Charlotte J. , Park Jungmi , Luther David C. , Im Jungkyun , Rotello Caren M. , Mager Jesse , Rotello Vincent M. 
Published: August 2024

AbstractSelf‐assembly of small interfering RNA (siRNA) with a block copolymer featuring guanidinium and zwitterion functionalized blocks generates core‐shell‐like nanovectors that provide cytosolic access to siRNA and efficiently evade phagocytic clearance. The guanidinium‐functionalized inner block complexes siRNA in the nanovector interior and enables cytosolic delivery. The zwitterionic outer block provides a non‐interacting shell on the nanovectors that reduces macrophage uptake in vitro and phagocytic clearance and enhances tumor localization in vivo. These nanovectors are used to treat a 4T1 (murine) model of triple‐negative breast cancer (TNBC). The nanovectors deliver siRNA efficiently to 4T1 triple‐negative breast cancer cells in vitro, with high selectivity relative to macrophages. This efficiency and selectivity translate into in vivo efficacy: diblock nanovectors evaded phagocytic clearance and efficiently localized in an aggressive murine 4T1 orthotopic model, with a ≈3‐fold increase of vector residing in the tumor compared to the homopolymer nanovectors. This increased localization efficiently knocked down STAT3 (≈80%) and provided tumorostasis (100% growth inhibition) at a low dose of 0.14 mg kg−1. The in vitro and in vivo efficacy of these nanovectors demonstrate the potential of engineered polymer architectures to generate effective self‐assembled siRNA therapeutics that avoid phagocytic clearance for the treatment of diseases requiring systemic administration.