bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Personal/Subpersonal Distinction
Authors: Drayson Zoe 
Published: April 2014

AbstractDaniel Dennett's distinction between personal and subpersonal explanations was fundamental in establishing the philosophical foundations of cognitive science. Since it was first introduced in 1969, the personal/subpersonal distinction has been adapted to fit different approaches to the mind. In one example of this, the ‘Pittsburgh school’ of philosophers attempted to map Dennett's distinction onto their own distinction between the ‘space of reasons’ and the ‘space of causes’. A second example can be found in much contemporary philosophy of psychology, where Dennett's distinction has been presumed to be equivalent to Stephen Stich's distinction between doxastic and subdoxastic states. Both these interpretations of the personal/subpersonal distinction, and also Dennett's own philosophical views of the mind, go beyond the personal/subpersonal distinction itself. They each involve supplementing the distinction between personal and subpersonal explanations with metaphysical claims about the relationship between the two kinds of explanation and the entities they posit.
The Concept of Intersectionality in Feminist Theory
Authors: Carastathis Anna 
Published: April 2014

AbstractIn feminist theory, intersectionality has become the predominant way of conceptualizing the relation between systems of oppression which construct our multiple identities and our social locations in hierarchies of power and privilege. The aim of this essay is to clarify the origins of intersectionality as a metaphor, and its theorization as a provisional concept in Kimberlé Williams Crenshaw's work, followed by its uptake and mainstreaming as a paradigm by feminist theorists in a period marked by its widespread and rather unquestioned – if, at times, superficial and inattentive – usage. I adduce four analytic benefits of intersectionality as a research paradigm: simultaneity, complexity, irreducibility, and inclusivity. Then, I gesture at some critiques of intersectionality advanced in the last few years, during which the concept has increasingly come under scrutiny.
Therapeutic efficacies of chitosan against Pneumocystis pneumonia of immunosuppressed rat
Authors: Liu A.‐B. , Pu Y. , Zheng Y.‐Q. , Cai H. , Ye B. 
Published: April 2014

SummaryThis study was designed to investigate the therapeutic efficacy of chitosan on Pneumocystis pneumonia (PCP) in immunosuppressed rats. The PCP rat model was established using intramuscular injections of dexamethasone sodium phosphate. To estimate treatment effects of chitosan on rat PCP, weight gain, lung weight, lung weight/body weight (LW/BW) ratio and per cent survival were measured and the HSP70 mRNA expression of Pneumocystis carinii was detected using real‐time PCR analysis. Rat lung tissues were stained with HE, and their pathological changes, inflammatory cells and alveolar macrophages were observed by light microscopy. Rat lymphocyte numbers and the concentrations of IL‐10, IFN‐γ and TNF‐α were measured by flow cytometry and ELISA analysis. Additionally, the ultrastructure of P. carinii was examined by electron microscopy to evaluate the effects of chitosan on the protist. Our results demonstrated that chitosan has some apparent treatment effects on rat PCP by reducing HSP70 mRNA expression and lung inflammation, increasing the concentrations of IL‐10 and IFN‐γ as well as CD4+ T‐lymphocyte numbers, reducing the CD8+ T‐lymphocyte numbers and the concentration of TNF‐α and inducing significant ultrastructural damage to P. carinii. Although its precise therapeutic mechanism has yet to be determined, these results lay a theoretical foundation for PCP chitosan therapy.
On how thin submarine flows transported large volumes of sand for hundreds of kilometres across a flat basin plain without eroding the sea floor
Authors: Stevenson Christopher J. , Talling Peter J. , Sumner Esther J. , Masson Douglas G. , Frenz Micheal , Wynn Russell B. 
Published: April 2014

AbstractSubmarine gravity currents, especially long run‐out flows that reach the deep ocean, are exceptionally difficult to monitor in action, hence there is a need to reconstruct how these flows behave from their deposits. This study mapped five individual flow deposits (beds) across the Agadir Basin, offshore north‐west Africa. This is the only data set where bed shape, internal distribution of lithofacies, changes in grain size and sea floor gradient, bed volumes, flow thickness and depth of erosion into underlying hemipelagic mud are known for individual beds. Some flows were 30 to 120 m thick. However, flows with the highest fraction of sand were less than 5 to 14 m thick. Sand was most likely to be carried in the lower 5 to 7 m of these flows. Despite being relatively thin, one flow was capable of transporting very large volumes of sediment (ca 200 km3) for large distances across very flat sea floor. These observations show that these relatively thin flows could travel quickly enough on very low gradients (0·02° to 0·05°) to suspend sand several metres to tens of metres above the sea floor, and maintain those speeds for up to 250 km across the basin. Near uniform hemipelagic mud interval thickness between beds, and coccolith assemblages in the mud caps of beds, suggest that the flows did not erode significantly into the underlying sea floor mud. Simple calculations imply that some flows, especially in the proximal part of the basin, were powerful enough to have eroded hemipelagic mud if it was exposed to the flow. This suggests that the flows were depositional from the moment they arrived at a basin plain location, and that deposition shielded the underlying hemipelagic mud from erosion. Reproducing the field observations outlined in this exceptionally detailed field data set is a challenge for future experimental and numerical models.
Of sand and mud: Sedimentological criteria for identifying the turbidity maximum zone in a tidally influenced river
Authors: La Croix Andrew D. , Dashtgard Shahin E. 
Published: April 2014

AbstractThe thickness and lateral distribution of sand and mud beds and bedsets on channel bars from the tidally influenced Fraser River, British Columbia, Canada, are quantitatively assessed. Fifty‐six vibracores totalling ca 114 m of vertical section are used to tabulate bed thicknesses. Statistical calculations are undertaken for nine channel bars ranging from the freshwater and tidal zone, to the sustained brackish water and tidal zone. The data reveal that thickness trends can be organized into three groups that broadly correspond to time‐averaged hydrodynamic and salinity conditions in the various distributary channels. Thick sand beds (up to 30 cm) and thin mud beds (up to 5 cm) characterize the freshwater tidal zone. The tidal and freshwater to brackish‐water transition zone comprises thin sands (up to 10 cm) and thicker muds (up to 19 cm), and the sustained brackish water tidal zone consists of thin muds (up to 6 cm) with relatively thicker sands (up to 25 cm). The results suggest that the locus of mud deposition occurs in the tidal freshwater to brackish‐water zone, probably reflecting mud flocculation and deposition at the turbidity maximum. Landward of the turbidity maximum, mud deposition is linked to tidal influence (tidal backwater effect and reverse eddy currents on channel margins) as mud beds thin in the landward direction. These results support the hypothesis that mud deposition is greatest at the turbidity maximum and decreases in both the seaward and landward direction. This study also showcases that mud‐bed thicknesses are greatest towards the turbidity maximum and thin in both the landward and seaward direction. In the rock record, the apex of mud deposition probably marks the position of the palaeo‐turbidity maximum.
Why Cornell Moral Realism Cannot Provide an Adequate Account of Moral Knowledge
Authors: Tropman Elizabeth 
Published: April 2014

AbstractAccording to Cornell moral realists, we can know about moral facts in much the same way that we do the empirical facts of the natural sciences. In “Can Cornell Moral Realism Adequately Account for Moral Knowledge?” (2012), I argue that this positive comparison to scientific knowledge hurts, rather than helps, the moral realist position. Joseph Long has recently defended Cornell moral realism against my concerns. In this article, I respond to Long's arguments and clarify important issues in the present debate.
Classification of finite-dimensional irreducible modules over -algebras
Authors: Losev Ivan , Ostrik Victor 
Published: April 2014

AbstractFinite $W$-algebras are certain associative algebras arising in Lie theory. Each $W$-algebra is constructed from a pair of a semisimple Lie algebra ${\mathfrak{g}}$ (our base field is algebraically closed and of characteristic 0) and its nilpotent element $e$. In this paper we classify finite-dimensional irreducible modules with integral central character over $W$-algebras. In more detail, in a previous paper the first author proved that the component group $A(e)$ of the centralizer of the nilpotent element under consideration acts on the set of finite-dimensional irreducible modules over the $W$-algebra and the quotient set is naturally identified with the set of primitive ideals in $U({\mathfrak{g}})$ whose associated variety is the closure of the adjoint orbit of $e$. In this paper, for a given primitive ideal with integral central character, we compute the corresponding $A(e)$-orbit. The answer is that the stabilizer of that orbit is basically a subgroup of $A(e)$ introduced by G. Lusztig. In the proof we use a variety of different ingredients: the structure theory of primitive ideals and Harish-Chandra bimodules for semisimple Lie algebras, the representation theory of $W$-algebras, the structure theory of cells and Springer representations, and multi-fusion monoidal categories.
Effect of Cyclic Mechanical Stimulation on the Expression of Osteogenesis Genes in Human Intraoral Mesenchymal Stromal and Progenitor Cells
Authors: Lohberger Birgit , Kaltenegger Heike , Stuendl Nicole , Payer Michael , Rinner Beate , Leithner Andreas 
Published: April 2014

We evaluated the effects of mechanical stimulation on the osteogenic differentiation of human intraoral mesenchymal stem and progenitor cells (MSPCs) using the Flexcell FX5K Tension System that mediated cyclic tensile stretch on the cells. MSPCs were isolated from human mandibular retromolar bones and characterized using flow cytometry. The positive expression of CD73, CD90, and CD105 and negativity for CD14, CD19, CD34, CD45, and HLA-DR confirmed the MSPC phenotype. Mean MSPC doubling time was30.4 ± 2.1 hrs. The percentage of lactate dehydrogenase (LDH) release showed no significant difference between the mechanically stimulated groups and the unstimulated controls. Reverse transcription quantitative real-time PCR revealed that 10% continuous cyclic strain (0.5 Hz) for 7 and 14 days induced a significant increase in the mRNA expression of the osteogenesis-specific markers type-I collagen (Col1A1), osteonectin (SPARC), bone morphogenetic protein 2 (BMP2), osteopontin (SPP1), and osteocalcin (BGLAP) in osteogenic differentiated MSPCs. Furthermore, mechanically stimulated groups produced significantly higher amounts of calcium deposited into the cultures and alkaline phosphatase (ALP). These results will contribute to a better understanding of strain-induced bone remodelling and will form the basis for the correct choice of applied force in oral and maxillofacial surgery.
Admissible Solutions of the Schwarzian Type Difference Equation
Authors: Chen Baoqin , Li Sheng 
Published: April 2014

This paper is to investigate the Schwarzian type difference equationΔ3f/Δf-3/2Δ2f/Δf2k=Rz,f=P(z,f)/Q(z,f),whereR(z,f)is a rational function infwith polynomial coefficients,P(z,f), respectivelyQ(z,f)are two irreducible polynomials infof degreep, respectivelyq. Relationship betweenpandqis studied for some special case. Denoted=max⁡p,q. Letf(z)be an admissible solution of(*)such thatρ2(f)<1; then fors (≥2) distinct complex constantsα1,…,αs ,q+2k∑j=1sδ(αj,f)≤ 8k.In particular, ifN(r,f)=S(r,f), thend+2k∑j=1sδ (αj,f)≤4k.
Sexual dimorphism in Tripedaliidae (Conant 1897) (Cnidaria, Cubozoa, Carybdeida)
Authors: STRAEHLER-POHL ILKA , GARM ANDERS , MORANDINI ANDRÉ C. 
Published: April 2014

The family Tripedaliidae was re-defined and expanded based on a molecular phylogenetic hypothesis by Bentlage et al. (2010, Proceedings of the Royal Society Biological Science, 277: 497). Additionally, Bentlage et al. (2010) proposed that all members of the family Tripedaliidae present dimorphism in gonads and have structures that function as seminal vesicles (at least in males). Until now, no information on Tripedalia binata concerning gonad morphology, sexual dimorphism, spermatophore formation or structures that serve as seminal vesicles or spermathecae were published. We studied mature medusae of both sexes of Tripedalia cystophora, Tripedalia binata and Copula sivickisi in order to compare these structures in their stomach regions. We found sexual dimorphism and spermatophore formation in seminal vesicle-like structures in all three species. In particular, we show that along with the females of Copula sivickisi, the females of Tripedalia cystophora and Tripedalia binata also possess structures that store spermatophores and serve as spermathecae. The results are in agreement with the morphological synapomorphies for Tripedaliidae outlined in Bentlage et al. (2010), but suggest an adjustment of the diagnosis of Tripedaliidae (underlined): All carybdeids that display sexual dimorphism of the gonads, produce spermatophores and in which males and females possess subgastral sacs, pockets or purses which function as seminal vesicles or spermathecae.
A Numerical Study on the Ventilation Coefficients of Falling Hailstones
Authors: Cheng Kai-Yuan , Wang Pao K. , Wang Chen-Kang 
Published: April 2014

Abstract
The ventilation coefficients that represent the enhancement of mass transfer rate due to the falling motion of spherical hailstones in an atmosphere of 460 hPa and 248 K are computed by numerically solving the unsteady Navier–Stokes equation for airflow past hailstones and the convective diffusion equation for water vapor diffusion around the falling hailstones. The diameters of the hailstones investigated are from 1 to 10 cm, corresponding to Reynolds number from 5935 to 177 148. The calculated ventilation coefficients vary approximately linearly with the hailstone diameter, from about 19 for a 1-cm hailstone to about 208 for a 10-cm hailstone. Empirical formulas for ventilation coefficient variation with hailstone diameter as well as Reynolds and Schmidt numbers are given. Implications of these ventilation coefficients are discussed.
A High-Resolution Lightning Map of the State of Colorado
Authors: Vogt Brandon J. , Hodanish Stephen J. 
Published: April 2014

Abstract
For the state of Colorado, 10 years (2003–12) of 1 April–31 October cloud-to-ground (CG) lightning stroke data are mapped at 500-m spatial resolution over a 10-m spatial resolution U.S. Geological Survey (USGS) digital elevation model (DEM). Spatially, the 12.5 million strokes that are analyzed represent ground contacts, but translate to density values that are about twice the number of ground contacts. Visual interpretation of the mapped data reveals the general lightning climatology of the state, while geospatial analyses that quantify lightning activity by elevation identify certain topographic influences of Colorado’s physical landscape. Elevations lower than 1829 m (6000 ft) and above 3200 m (10 500 ft) show a positive relationship between lightning activity and elevation, while the variegated topography that lies between these two elevations is characterized by a fluctuating relationship. Though many topographic controls are elucidated through the mappings and analyses, the major finding of this paper is the sharp increase in stroke density observed above 3200 m (10 500 ft). Topography’s role in this rapid surge in stroke density, which peaks in the highest mountain summits, is not well known, and until now, was not well documented in the refereed literature at such high resolution from a long-duration dataset.
A functional screen for copper homeostasis genes identifies a pharmacologically tractable cellular system
Authors: Schlecht Ulrich , Suresh Sundari , Xu Weihong , Aparicio Ana Maria , Chu Angela , Proctor Michael J , Davis Ronald W , Scharfe Curt , St Onge Robert P 
Published: April 2014

AbstractBackgroundCopper is essential for the survival of aerobic organisms. If copper is not properly regulated in the body however, it can be extremely cytotoxic and genetic mutations that compromise copper homeostasis result in severe clinical phenotypes. Understanding how cells maintain optimal copper levels is therefore highly relevant to human health.ResultsWe found that addition of copper (Cu) to culture medium leads to increased respiratory growth of yeast, a phenotype which we then systematically and quantitatively measured in 5050 homozygous diploid deletion strains. Cu’s positive effect on respiratory growth was quantitatively reduced in deletion strains representing 73 different genes, the function of which identify increased iron uptake as a cause of the increase in growth rate. Conversely, these effects were enhanced in strains representing 93 genes. Many of these strains exhibited respiratory defects that were specifically rescued by supplementing the growth medium with Cu. Among the genes identified are known and direct regulators of copper homeostasis, genes required to maintain low vacuolar pH, and genes where evidence supporting a functional link with Cu has been heretofore lacking. Roughly half of the genes are conserved in man, and several of these are associated with Mendelian disorders, including the Cu-imbalance syndromes Menkes and Wilson’s disease. We additionally demonstrate that pharmacological agents, including the approved drug disulfiram, can rescue Cu-deficiencies of both environmental and genetic origin.ConclusionsA functional screen in yeast has expanded the list of genes required for Cu-dependent fitness, revealing a complex cellular system with implications for human health. Respiratory fitness defects arising from perturbations in this system can be corrected with pharmacological agents that increase intracellular copper concentrations.
Genome sequence of Ensifer adhaerens OV14 provides insights into its ability as a novel vector for the genetic transformation of plant genomes
Authors: Rudder Steven , Doohan Fiona , Creevey Christopher J , Wendt Toni , Mullins Ewen 
Published: April 2014

Abstract

Background
Recently it has been shown that Ensifer adhaerens can be used as a plant transformation technology, transferring genes into several plant genomes when equipped with a Ti plasmid. For this study, we have sequenced the genome of Ensifer adhaerens OV14 (OV14) and compared it with those of Agrobacterium tumefaciens C58 (C58) and Sinorhizobium meliloti 1021 (1021); the latter of which has also demonstrated a capacity to genetically transform crop genomes, albeit at significantly reduced frequencies.

Results
The 7.7 Mb OV14 genome comprises two chromosomes and two plasmids. All protein coding regions in the OV14 genome were functionally grouped based on an eggNOG database. No genes homologous to the A. tumefaciens Ti plasmid vir genes appeared to be present in the OV14 genome. Unexpectedly, OV14 and 1021 were found to possess homologs to chromosomal based genes cited as essential to A. tumefaciens T-DNA transfer. Of significance, genes that are non-essential but exert a positive influence on virulence and the ability to genetically transform host genomes were identified in OV14 but were absent from the 1021 genome.

Conclusions
This study reveals the presence of homologs to chromosomally based Agrobacterium genes that support T-DNA transfer within the genome of OV14 and other alphaproteobacteria. The sequencing and analysis of the OV14 genome increases our understanding of T-DNA transfer by non-Agrobacterium species and creates a platform for the continued improvement of Ensifer-mediated transformation (EMT).
A descriptive study of colorectal function in adults with Prader-Willi Syndrome: high prevalence of constipation
Authors: Kuhlmann Louise , Joensson Iben Moeller , Froekjaer Jens Broendum , Krogh Klaus , Farholt Stense 
Published: April 2014

Abstract

Background
Some patients with Prader-Willi Syndrome (PWS) have symptoms of constipation, but bowel function in PWS has never been systematically evaluated. The aim of the present study was to describe colorectal function in PWS by means of validated techniques.

Methods
Twenty-one patients with PWS (14 women, age 17–47 (median = 32)) were evaluated with the Rome III constipation criteria, stool diary, digital rectal examination, rectal diameter assessed from transabdominal ultrasound, and total gastrointestinal transit time (GITT) determined with radio-opaque markers. Results were compared with those of healthy controls.

Results
Among PWS patients able to provide information for Rome III criteria, 8/20 (40%) fulfilled the criteria for constipation. Most commonly reported symptoms were a feeling of obstructed defecation (8/19, 42%), <3 defecations per week (8/17, 47%), straining during defecation (7/19, 37%) and lumpy or hard stools (6/19, 32%). Rectal diameter did not differ between PWS (median 3.56 centimeters, range 2.24–5.36) and healthy controls (median 3.42 centimeters, range 2.67–4.72) (p = 0.96), but more PWS patients (13/20; 65%) than healthy controls (3/25; 12%) (p < 0.001) had fecal mass in the rectum. Median GITT was 2.0 days (range 0.5–4.4) in PWS versus 1.6 (range 0.7–2.5) in the control group (p = 0.26). However, GITT was >3 days in 5/21 (24%) of PWS and none of the controls (p = 0.047).

Conclusion
Constipation is very common in PWS. Patients with PWS have an increased prevalence of prolonged GITT and palpable stools in the rectum at digital rectal examination.