bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Beijing version of the montreal cognitive assessment as a brief screening tool for mild cognitive impairment: a community-based study
Authors: Yu Jing , Li Juan , Huang Xin 
Published: September 2012

Abstract

Background
A cross-sectional validation study was conducted in several urban and rural communities in Beijing, China, to evaluate the effectiveness of the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) as a screening tool to detect mild cognitive impairment (MCI) among Chinese older adults.

Methods
The MoCA-BJ and the Mini-Mental State Examination (MMSE) were administered to 1001 Chinese elderly community dwellers recruited from three different regions (i.e., newly developed, old down-town, and rural areas) in Beijing. Twenty-one of these participants were diagnosed by experienced psychiatrists as having dementia, 115 participants were diagnosed as MCI, and 865 participants were considered to be cognitively normal. To analyze the effectiveness of the MoCA-BJ, we examined its psychometric properties, conducted item analyses, evaluated the sensitivity and specificity of the scale, and compared the scale with the MMSE. Demographic and regional differences among our subjects were also taken into consideration.

Results
Under the recommended cut-off score of 26, the MoCA-BJ demonstrated an excellent sensitivity of 90.4%, and a fair specificity (31.3%). The MoCA-BJ showed optimal sensitivity (68.7%) and specificity (63.9%) when the cut-off score was lowered to 22. Among all the seven cognitive sub-domains, delayed recall was shown to be the best index to differentiate MCI from the normal controls. Regional differences disappeared when the confounding demographic variables (i.e., age and education) were controlled. Item analysis showed that the internal consistency was relatively low in both naming and sentence repetition tasks, and the diagnostic accuracy was similar between the MoCA-BJ and the MMSE.

Conclusions
In general, the MoCA-BJ is an acceptable tool for MCI screening in both urban and rural regions of Beijing. However, presumably due to the linguistic and cultural differences between the original English version and the Chinese version of the scale, and the lower education level of Chinese older adults, the MoCA-BJ is not much better than the MMSE in detecting MCI, at least for this study sample. Further modifications to several test items of the MoCA-BJ are recommended in order to improve the applicability and effectiveness of the MoCA-BJ in MCI screening among the Chinese population.
No red cell alloimmunization or change of clinical outcome after using fresh frozen cancellous allograft bone for acetabular reconstruction in revision hip arthroplasty: a follow up study
Authors: Mittag Falk , Straub Matthias , Schäfer Richard , Kluba Torsten , Ipach Ingmar 
Published: September 2012

Abstract

Background
Possible immunization to blood group or other antigens and subsequent inhibition of remodeling or incorporation after use of untreated human bone allograft was described previously. This study presents the immunological, clinical and radiological results of 30 patients with acetabular revisions using fresh frozen non-irradiated bone allograft.

Methods
AB0-incompatible (donor-recipient) bone transplantation was performed in 22 cases, Rh(D) incompatible transplantation in 6 cases. The mean follow up of 23 months included measuring Harris hip score and radiological examination with evaluation of remodeling of the bone graft, implant migration and heterotopic ossification. In addition, all patients were screened for alloimmunization to Rh blood group antigens.

Results
Compared to the whole study group, there were no differences in clinical or radiological measurements for the groups with AB0- or Rh(D)-incompatible bone transplantation. The mean Harris Hip Score was 80.6. X-rays confirmed total remodeling of all allografts with no acetabular loosening. At follow up, blood tests revealed no alloimmunization to Rh blood group donor antigens.

Conclusions
The use of fresh frozen non-irradiated bone allograft in acetabular revision is a reliable supplement to reconstruction. The risk of alloimmunization to donor-blood group antigens after AB0- or Rh-incompatible allograft transplantation with a negative long-term influence on bone-remodeling or the clinical outcome is negligible.
Personal health records in the preclinical medical curriculum: modeling student responses in a simple educational environment utilizing Google Health
Authors: Karamanlis Dimokratis A , Tzitzis Panagiotis M , Bratsas Charalampos A , Bamidis Panagiotis D 
Published: September 2012

Abstract

Background
Various problems concerning the introduction of personal health records in everyday healthcare practice are reported to be associated with physicians’ unfamiliarity with systematic means of electronically collecting health information about their patients (e.g. electronic health records - EHRs). Such barriers may further prevent the role physicians have in their patient encounters and the influence they can have in accelerating and diffusing personal health records (PHRs) to the patient community. One way to address these problems is through medical education on PHRs in the context of EHR activities within the undergraduate medical curriculum and the medical informatics courses in specific. In this paper, the development of an educational PHR activity based on Google Health is reported. Moreover, student responses on PHR’s use and utility are collected and presented. The collected responses are then modelled to relate the satisfaction level of students in such a setting to the estimation about their attitude towards PHRs in the future.

Methods
The study was conducted by designing an educational scenario about PHRs, which consisted of student instruction on Google Health as a model PHR and followed the guidelines of a protocol that was constructed for this purpose. This scenario was applied to a sample of 338 first-year undergraduate medical students. A questionnaire was distributed to each one of them in order to obtain Likert-like scale data on the sample’s response with respect to the PHR that was used; the data were then further analysed descriptively and in terms of a regression analysis to model hypothesised correlations.

Results
Students displayed, in general, satisfaction about the core PHR functions they used and they were optimistic about using them in the future, as they evaluated quite high up the level of their utility. The aspect they valued most in the PHR was its main role as a record-keeping tool, while their main concern was related to the negative effect their own opinion might have on the use of PHRs by patients. Finally, the estimate of their future attitudes towards PHR integration was found positively dependent of the level of PHR satisfaction that they gained through their experience (rho = 0.524, p <0.001).

Conclusions
The results indicate that students support PHRs as medical record keeping helpers and perceive them as beneficial to healthcare. They also underline the importance of achieving good educational experiences in improving PHR perspectives inside such educational activities. Further research is obviously needed to establish the relative long-term effect of education to other methods of exposing future physicians to PHRs.
High density trans-admittance mammography development and preliminary phantom tests
Authors: Zhao Mingkang , Wi Hun , Mostofa Kamal Abu Hena , McEwan Alistair Lee , Woo Eung Je , Oh Tong In 
Published: September 2012

Abstract

Background
Malignant breast tumor tissue has a significantly different electrical impedance spectrum than surrounding normal tissues. This has led to the development of impedance imaging as a supplementary or alternative method to X-ray mammography for screening and assessment of breast cancers. However low spatial resolution and poor signal to noise ratio has limited the clinical application.

Methods
In order to improve spatial resolution we developed a trans-admittance mammography (TAM) system including an array of 60×60 current sensing electrodes. We adopted a similar setup to X-ray mammography where the breast is situated between two holding plates. The top plate is a large solid metal electrode for applying a sinusoidal voltage over a range of frequencies from 50 Hz to 500 kHz. The bottom plate has 3600 current sensing electrodes that are kept at the ground potential. Currents are generated from the top voltage-applying electrode and spread throughout the breast, entering the TAM system through the array of current sensing electrodes on the bottom plate. The TAM system measures the exit currents through 6 switching modules connected to 600 electrodes each. Each switching module is connected to 12 ammeter channels which are switched sequentially to 50 of the 600 electrodes each measurement time. Each ammeter channel is comprised of a current-to-voltage converter, a gain amplifier, filters, an analog to digital converter, and a digital phase sensitive demodulator.

Results
We found an average noise level of 38 nA, amplitude stability of less than 0.2%, crosstalk of better than -60 dB and 70 dB signal to noise ratio over all channels and operating frequencies. Images were obtained in time difference and frequency difference modes in a saline phantom.

Conclusion
We describe the design, construction, and calibration of a high density TAM system in detail. Successful high resolution time and frequency difference images showed regions of interest with the expected admittivity changes in the frequency spectrum.
Collaborative software for traditional and translational research
Authors: Berman Ari E , Barnett William K , Mooney Sean D 
Published: September 2012

Abstract
Biomedical research has entered a period of renewed vigor with the introduction and rapid development of genomic technologies and next-generation sequencing methods. This research paradigm produces extremely large datasets that are both difficult to store and challenging to mine for relevant data. Additionally, the thorough exploration of such datasets requires more resources, personnel, and multidisciplinary expertise to properly analyze and interpret the data. As a result, modern biomedical research practices are increasingly designed to include multi-laboratory collaborations that effectively distribute the scientific workload and expand the pool of expertise within a project. The scope of biomedical research is further complicated by increased efforts in translational research, which mandates the translation of basic laboratory research results into the human medical application space, adding to the complexity of potential collaborations. This increase in multidisciplinary, multi-laboratory, and biomedical translational research identifies a specific need for formalized collaboration practices and software applications that support such efforts. Here, we describe formal technological requirements for such efforts and we review several software solutions that can effectively improve the organization, communication, and formalization of collaborations in biomedical research today.
TCP’s dynamic adjustment of transmission rate to packet losses in wirelessnetworks
Authors: Park Mi-Young , Chung Sang-Hwa , Ahn Chang-Woo 
Published: September 2012

Abstract
Based on the assumption of transmission control protocol (TCP) that packetsare lost due to congestion, TCP’s congestion control algorithms suchas fast retransmit/recovery (FRR) and retransmission timeouts (RTO)unconditionally reduce the transmission rate for every packet loss. When TCPoperates in wireless networks, however, FRRs/RTOs are often triggeredregardless of congestion due to sudden delay and wireless transmissionerrors. The congestion irrelative FRRs/RTOs incur TCP’s misbehaviorsuch as blindly halving the transmission rate, unnecessarily retransmittingthe outstanding packets which may be in the bottleneck queue. Although manyprevious studies have been proposed to detect the congestion irrelativeFRRs/RTOs, they paid little attention on effectively adjusting thetransmission rate for the detected congestion irrelative FRRs/RTOs.
In this article, we propose an enhanced TCP to dynamically adjust itstransmission rate according to network conditions. Our scheme adjusts thetransmission rate in proportion to the available bandwidth in order toquickly utilize the available bandwidth, and also re-adjusts it in inverseproportion to the loss rate in order to avoid burst losses and longgo-back-N retransmissions. By doing so, our scheme hassignificant effects to avoid the performance degradation caused by thecongestion irrelative FRRs/RTOs. Throughout the extensive experiments, weevaluate our scheme and compare it with previous works in terms of goodput,fairness, and friendless under various network topologies. The results showthat our scheme significantly outperforms previous studies while itmaintains the fair and friendly behavior to other TCP connections.
Existence results for nonlinear fractional differential equations with closed boundary conditions and impulses
Authors: Wang Guotao , Ahmad Bashir , Zhang Lihong 
Published: September 2012

Abstract
This paper is concerned with the existence and uniqueness of solutions for impulsive nonlinear differential equations of fractional order

α
∈
(
1
,
2
]

with closed boundary conditions. By applying some standard fixed point theorems, we obtain the sufficient conditions for the existence and uniqueness of solutions of the problem at hand. An illustrative example is presented.

MSC:26A33, 34B15, 34B37.
Optimal SP frame selection and bit budget allocation for mobile H.264 video streaming
Authors: Colonnese Stefania , Rinauro Stefano , Rossi Lorenzo , Scarano Gaetano 
Published: September 2012

AbstractMobile video streaming services are challenging, as they obey several system constraints, such as random access facilities, efficient server storage, and flexible rate adaptation. Rate adaptation can be performed by means of seamless switching among different encoded bitstreams. The H.264 video coding standard explicitly supports bitstream switching using specific frame coding modes, namely switching pictures (SP). Locations of SP frames affect the overall bit rate and quality of streamed video. In this study, we address the issue of optimal joint selection of the SP frames locations and bit budget allocation at frame layer. The optimization is carried out via a game theoretic approach under assigned system constraints on the overall streaming rate and the maximum random access delay. Numerical simulations show that our frame layer optimal encoding procedure brings advantages in terms of several characteristics of the streamed video, encompassing enhanced rate-distortion, reduced transmission buffer occupancy, equalization of the transmission delays, and more efficient switching.
Diagnostic issues and capabilities in 48 isolation facilities in 16 European countries: data from EuroNHID surveys
Authors: Thiberville Simon-Djamel , Schilling Stefan , De Iaco Giuseppina , Fusco Francesco Maria , Thomson Gail , Maltezou Helen C , Gottschalk Rene , Brodt Reinhard H , Bannister Barbara , Puro Vincenzo , Ippolito Giuseppe , Brouqui Philippe 
Published: September 2012

Abstract

Background
Highly infectious diseases (HIDs) are defined as being transmissible from person to person, causing life-threatening illnesses and presenting a serious public health hazard. The sampling, handling and transport of specimens from patients with HIDs present specific bio-safety concerns.

Findings
The European Network for HID project aimed to record, in a cross-sectional study, the infection control capabilities of referral centers for HIDs across Europe and assesses the level of achievement to previously published guidelines. In this paper, we report the current diagnostic capabilities and bio-safety measures applied to diagnostic procedures in these referral centers. Overall, 48 isolation facilities in 16 European countries were evaluated. Although 81% of these referral centers are located near a biosafety level 3 laboratory, 11% and 31% of them still performed their microbiological and routine diagnostic analyses, respectively, without bio-safety measures.

Conclusions
The discrepancies among the referral centers surveyed between the level of practices and the European Network of Infectious Diseases (EUNID) recommendations have multiple reasons of which the interest of the individuals in charge and the investment they put in preparedness to emerging outbreaks. Despite the fact that the less prepared centers can improve by just updating their practice and policies any support to help them to achieve an acceptable level of biosecurity is welcome.
Early data from project engage: a program to identify and transition medically hospitalized patients into addictions treatment
Authors: Pecoraro Anna , Horton Terry , Ewen Edward , Becher Julie , Wright Patricia A , Silverman Basha , McGraw Patty , Woody George E 
Published: September 2012

Abstract

Background
Patients with untreated substance use disorders (SUDs) are at risk for frequent emergency department visits and repeated hospitalizations. Project Engage, a US pilot program at Wilmington Hospital in Delaware, was conducted to facilitate entry of these patients to SUD treatment after discharge. Patients identified as having hazardous or harmful alcohol consumption based on results of the Alcohol Use Disorders Identification Test-Primary Care (AUDIT-PC), administered to all patients at admission, received bedside assessment with motivational interviewing and facilitated referral to treatment by a patient engagement specialist (PES). This program evaluation provides descriptive information on self-reported rates of SUD treatment initiation of all patients and health-care utilization and costs for a subset of patients.

Methods
Program-level data on treatment entry after discharge were examined retrospectively. Insurance claims data for two small cohorts who entered treatment after discharge (2009, n = 18, and 2010, n = 25) were reviewed over a six-month period in 2009 (three months pre- and post-Project Engage), or over a 12-month period in 2010 (six months pre- and post-Project Engage). These data provided descriptive information on health-care utilization and costs. (Data on those who participated in Project Engage but did not enter treatment were unavailable).

Results
Between September 1, 2008, and December 30, 2010, 415 patients participated in Project Engage, and 180 (43%) were admitted for SUD treatment. For a small cohort who participated between June 1, 2009, and November 30, 2009 (n = 18), insurance claims demonstrated a 33% ($35,938) decrease in inpatient medical admissions, a 38% ($4,248) decrease in emergency department visits, a 42% ($1,579) increase in behavioral health/substance abuse (BH/SA) inpatient admissions, and a 33% ($847) increase in outpatient BH/SA admissions, for an overall decrease of $37,760. For a small cohort who participated between June 1, 2010, and November 30, 2010 (n = 25), claims demonstrated a 58% ($68,422) decrease in inpatient medical admissions; a 13% ($3,308) decrease in emergency department visits; a 32% ($18,119) decrease in BH/SA inpatient admissions, and a 32% ($963) increase in outpatient BH/SA admissions, for an overall decrease of $88,886.

Conclusions
These findings demonstrate that a large percentage of patients entered SUD treatment after participating in Project Engage, a novel intervention with facilitated referral to treatment. Although the findings are limited by the retrospective nature of the data and the small sample sizes, they do suggest a potentially cost-effective addition to existing hospital services if replicated in prospective studies with larger samples and controls.
Positive effect of septimeb™ on mortality rate in severe sepsis: a novel non antibiotic strategy
Authors: Eslami Kaveh , Mahmoodpoor Ata , Ahmadi Arezoo , Abdollahi Mohammad , Kamali Koorosh , Mousavi Sarah , Najafi Atabak , Baeeri Maryam , Hamishehkar Hadi , Kouti Leila , Javadi Mohammad Reza , Mojtahedzadeh Mojtaba 
Published: September 2012

Abstract

Background
Septimeb is a new herbal-derived remedy, recently approved for its potential immunomodulatory effects. Regarding the key role of immune system in the pathogenesis of severe sepsis and lack of any standard treatment for improving survival of these patients; we evaluated the effect of Septimeb -as an adjutant to standard treatment-on inflammatory biomarkers and mortality rates in patients with severe sepsis.

Methods
In this multicenter, randomized, single-blind trial, we assigned patients with severe sepsis and Acute Physiology and Chronic Health Evaluation (APACHE II) score of more than 20 to receive standard treatment of severe sepsis (control group) or standard treatment plus Septimeb. This group was treated with Septimeb for 14 days then followed up for another14 days. APACHE score, Sequential Organ Failure Assessment (SOFA) and Simplified Acute Physiology Score (SAPS) were calculated daily. Blood samples were analyzed for interleukin 2 tumor necrosis factor-α, total antioxidant power, platelet growth factor and matrix metalloproteinase 2.

Results
A total of 29 patients underwent randomization (13 in control group and 16 in Septimeb group). There was significant difference between the Septimeb and control group in the 14 days mortality rate (18.8% vs. 53.85 respectively, P=0.048). Compared to control group, Septimeb was significantly effective in improving SAPS (P= 0.029), SOFA (P=0.003) and APACHE II (P=0.008) scores. Inflammatory biomarkers didn’t change significantly between the two groups (P>0.05).

Conclusion
Septimeb reduces mortality rates among patients with severe sepsis and it could be added as a safe adjutant to standard treatment of sepsis.
A novel method to quantify IRDye800CW fluorescent antibody probes ex vivo in tissue distribution studies
Authors: Oliveira Sabrina , Cohen Ruth , Walsum Marijke Stigter-van , van Dongen Guus AMS , Elias Sjoerd G , van Diest Paul J , Mali Willem , van Bergen en Henegouwen Paul MP 
Published: September 2012

Abstract

Background
We describe a new method for biodistribution studies with IRDye800CW fluorescent antibody probes. This method allows the quantification of the IRDye800CW fluorescent tracer in percentage of injected dose per gram of tissue (% ID/g), and it is herein compared to the generally used reference method that makes use of radioactivity.

Methods
Cetuximab was conjugated to both the near-infrared fluorophore IRDye800CW and/or the positron emitter 89-zirconium, which was injected in nude mice bearing A431 human tumor xenografts. Positron emission tomography (PET) and optical imaging were performed 24 h post-injection (p.i.). For the biodistribution study, organs and tumors were collected 24 h p.i., and each of these was halved. One half was used for the determination of probe uptake by radioactivity measurement. The other half was homogenized, and the content of the fluorescent probe was determined by extrapolation from a calibration curve made with the injected probe.

Results
Tumors were clearly visualized with both modalities, and the calculated tumor-to-normal tissue ratios were very similar for optical and PET imaging: 3.31 ± 1.09 and 3.15 ± 0.99, respectively. Although some variations were observed in ex vivo analyses, tumor uptake was within the same range for IRDye800CW and gamma ray quantification: 15.07 ± 3.66% ID/g and 13.92 ± 2.59% ID/g, respectively.

Conclusions
The novel method for quantification of the optical tracer IRDye800CW gives similar results as the reference method of gamma ray quantification. This new method is considered very useful in the context of the preclinical development of IRDye800CW fluorescent probes for optical molecular imaging, likely contributing to the selection of lead compounds that are the most promising for clinical translation.