bluuebunny/crossref_metadata_2025_split huggingface dataset:
Entérocolite nécrosante sous antipsychotiques : à propos d’un cas clinique
Authors: Merlot A. , Nargeot J. , Buard M. , Viala A. , Vacheron M.-N. 
Published: November 2013

IntroductionL’entérocolite nécrosante est une complication rare des antipsychotiques (un cas/2000 patients traités) ; tous les antipsychotiques peuvent y participer (63 % des patients de la littérature étaient traités par antipsychotique atypique), particulièrement lorsqu’ils sont associés à un traitement anticholinergique (antiparkinsonien, antidépresseur imipraminique) ; elle peut être un effet indésirable souvent méconnu, mais toujours grave car elle conduit au décès du patient dans 40 à 60 % des cas. Elle est peu documentée dans la littérature et essentiellement sous forme de cas cliniques.Cas cliniqueNous rapportons le cas d’un jeune patient âgé de 25 ans, pris en charge pour un trouble schizoaffectif depuis une dizaine d’années, non compliant aux soins et plusieurs fois hospitalisé sous contrainte, résistant à plusieurs séquences thérapeutiques. Ce jeune homme avait été réhospitalisé pour une rechute délirante marquée par un vécu délirant persécutif et hypochondriaque avec de multiples cénesthopathies, associées à des troubles du comportement à type d’agitation psychomotrice. Il a présenté un cas d’entérocolite nécrosante alors qu’il était traité par quétiapine et zuclopenthixol ASP, et a dû bénéficier d’une colectomie totale en urgence du fait d’un retard au diagnostic et au traitement, malgré un suivi somatique régulier assuré par un somaticien dans le service.Discussion et conclusionLe diagnostic est particulièrement difficile du fait de la non spécificité du tableau clinique, d’autant qu’elle est souvent la complication d’une constipation ancienne, que l’évolution peut être rapide, et que le pronostic reste réservé. A partir du cas présenté, nous proposons une revue de la littérature et nous discutons les facteurs de risque, les difficultés du diagnostic, les diagnostics différentiels, la physiopathologie et les préconisations thérapeutiques. Il s’agit d’une urgence médicale qu’il faut apprendre à reconnaître et à anticiper pour éviter une évolution spontanément défavorable.
Affinité sérotoninergique 5HT2 C et diabète médicamenteux : étude de pharmacoépidémiologie dans la base de pharmacoVigilance de l’OMS
Authors: Montastruc F. , Bagheri H. , Schmitt L. , Montastruc J.-L. , Lapeyre-Mestre M. 
Published: November 2013

ContexteLes mécanismes pharmacodynamiques à l’origine des diabètes médicamenteux sous neuroleptiques ne sont pas clairement établis [1]. Des données pharmacodynamiques expérimentales nous ont conduits à faire l’hypothèse d’une implication du récepteur sérotoninergique 5HT2 C [2,3].ObjectifÉvaluer une association entre le niveau d’affinité pour le récepteur 5HT2 C de certains psychotropes et la notification d’un diabète avec ces médicaments.MéthodesÀ partir de la base de données de pharmacovigilance de l’OMS, Vigibase®, nous avons identifié les observations enregistrées durant la période du 01/01/1994 au 29/03/2013, correspondant à une liste de 15 médicaments psychotropes d’affinité 5HT2 C connue. Nous avons recherché une disproportionnalité entre le niveau d’affinité 5HT2 C et la notification de diabète à l’aide de modèles de régression logistique. Le premier modèle ajustait sur les facteurs cliniques de confusion (modèle A) et le deuxième intégrait, en plus, les autres affinités réceptorielles (5HT2A, 5HT1A, D2, D3, Δ1et Δ2).RésultatsParmi les 100 966 notifications, 1 790 (1,77 %) correspondaient à un effet indésirable de type diabète médicamenteux. Nous avons retrouvé une association significative et croissante entre le niveau d’affinité 5HT2 C et les notifications de diabète. Dans le modèle A, par rapport à une affinité 5HT2 C faible (référence), le rapport de cote (RC) pour une affinité 5HT2 C moyenne était de 2,98 (IC 95 % [2,54–3,48]) et celui pour une affinité 5HT2 C importante de 5,85 (IC 95 % [5,03–6,80]). Ces résultats étaient renforcés par le modèle B : RC = 3,15 (IC 95 % [2,54–3,91]) pour une affinité moyenne, RC = 7,07 [5,79–8,64] pour une affinité importante.ConclusionsCe travail illustre une méthode d’étude de type pharmacovigilance-pharmacodynamique (étude PV-PD). Il établit une association entre le niveau d‘affinité 5HT2 C et les notifications de diabète dans Vigibase®. Des études intégrant le niveau d’activité pour le récepteur 5HT2 C sont nécessaires pour compléter ces résultats.
Palmitate de palipéridone à doses flexibles – Réponse thérapeutique, tolérance et sécurité d’emploi: une étude prospective chez des patients en période d’exacerbation aiguë d’un trouble schizophrénique après échec d’un traitement par antipsychotiques oraux
Authors: Schreiner A. , Bergmans P. , Cherubin P. , Rancans E. , Bez Y. , Parellada E. , Carpiniello B. , Vidailhet P. , Hargater L. 
Published: November 2013

ObjectifsÉvaluer la tolérance, la sécurité d’emploi et l’efficacité de doses flexibles de PP chez des patients adultes en période d’exacerbation aiguë d’une schizophrénie, après échec d’un traitement par antipsychotiques oraux.MéthodesÉtude internationale, prospective, ouverte, de six mois.Critères d’évaluationPositive and Negative Syndrome Scale (PANSS), Clinical Global Impression-Severity (CGI-S), événements indésirables (EI), changement de poids.RésultatsDeux cent douze patients (population en intention de traiter) : âge moyen 36,4 ± 12,1 ans, 59,0 % d’hommes, 85,4 % souffrant de schizophrénie paranoïde ont été inclus. La principale raison de la substitution d’un antipsychotique oral par le PP était un manque d’efficacité (45,8 %). 70,3 % des patients ont terminé l’étude de six mois. Les raisons les plus fréquentes d’arrêt précoce ont été : le choix du patient (9,4 %), des EI (9,0 %), les perdus de vue (4,7 %), le manque d’efficacité (2,8 %). Le score total moyen à la PANSS initiale (98,5 ± 20,1) a diminué, et ce dès j8, pour atteindre 67,4 ± 24,0 à la fin de l’étude (diminution de −31,0 ± 29,0, p < 0,0001). 66,7 % des patients ont eu une amélioration de plus de 30 % du score PANSS total et le pourcentage de patients jugés manifestement malades ou pire (CGI-S) a diminué de 75,1 % à 20,5 %. Les EIs (≥ 5 % patients) : douleur au site d’injection (13,7 %), insomnie (10,8 %), trouble psychotique (10,4 %), céphalées (6,1 %) et anxiété (6,1 %). Le changement moyen de poids a été de 2,6 ± 5,6 kg (IC 95 % [1,8; 3,4]).ConclusionsCes résultats confirment que le PP à doses flexibles est bien toléré et permet une réponse clinique précoce et cliniquement significative chez des patients en période d’exacerbation aiguë de leur trouble schizophrénique, après échec d’un traitement par antipsychotiques oraux.
La remédiation cognitive dans le trouble bipolaire : une étude de cas
Authors: Isaac C. , Fouques D. , Braha Zeitoun S. , Januel D. 
Published: November 2013

IntroductionLe trouble bipolaire est une maladie psychiatrique caractérisée par une alternance d’épisodes de dépression et/ou de manie, ainsi que de périodes de rémission plus ou moins partielles. Des études ont observé des déficits cognitifs chez les patients bipolaires, qui seraient présents dès le premier épisode et qui persisteraient tout au long de leur vie [4]. Ces troubles auraient un impact sur le fonctionnement psychosocial des patients [1]. Il n’existe actuellement aucune thérapie ciblant les déficits cognitifs des patients bipolaires. La remédiation cognitive est une thérapie permettant un entraînement des capacités cognitives et un apprentissage de stratégies de résolution de problèmes. Plusieurs études concluent à un effet bénéfique persistant de la thérapie chez les patients schizophrènes [3]. De nombreux auteurs suggèrent que la thérapie de remédiation cognitive pourrait également être bénéfique aux patients bipolaires [2].MéthodologieNotre étude a pour objectif d’observer l’intérêt que peut présenter la remédiation cognitive pour les patients bipolaires, à travers l’étude du parcours de Monsieur V., un patient bipolaire de type I, qui a suivi une thérapie individuelle de remédiation cognitive durant trois mois. Nous avons administré avant et après la thérapie un bilan clinique, un bilan neuropsychologique et le test de Rorschach.RésultatsLes résultats indiquent une amélioration des capacités cognitives et fonctionnelles du patient. Nous avons observé des améliorations comportementales, mais également un changement plus profond dans la manière dont le patient mobilise des capacités cognitives.ConclusionCes résultats suggèrent que des patients bipolaires pourraient bénéficier d’une thérapie de remédiation cognitive, et nécessiteraient d’être reproduits sur une plus large population.
The temperature premium: Warm temperatures increase product valuation
Authors: Zwebner Yonat , Lee Leonard , Goldenberg Jacob 
Published: November 2013

AbstractA series of five field and laboratory studies reveal a temperature‐premium effect: warm temperatures increase individuals' valuation of products. We demonstrate the effect across a variety of products using different approaches to measure or manipulate physical warmth and different assessments of product valuation. The studies suggest that exposure to physical warmth activates the concept of emotional warmth, eliciting positive reactions and increasing product valuation. Further supporting the causal role of emotional warmth, and following prior research relating greater positive feelings to reduced distance, we find that warm temperatures also reduce individuals' perceived distance from the target products.
Dissociated late potentials during sinus rhythm after radiofrequency ablation in a patient with postinfarction ventricular tachycardia
Authors: Nakahara Shiro , Hori Yuichi , Kobayashi Sayuki , Tsukada Naofumi , Sakai Yoshihiko , Takayanagi Kan 
Published: November 2013

AbstractA 72‐year‐old man with ischemic cardiomyopathy was admitted for the treatment of ventricular tachycardia (VT). Because his VT was poorly tolerated hemodynamically, substrate mapping was performed. The map revealed the presence of low‐voltage areas in the inferolateral wall of the LV. Late potentials (LPs) were recorded during sinus rhythm, and pacing at the site revealed a good pacemap for targeting the VT. Delivery of radiofrequency (RF) current to the area where LPs were recorded rendered the targeted VT noninducible. After RF delivery, dissociation of the LPs with an interval of 3140 ms was documented during sinus rhythm.
A BIFURCATION APPROACH FOR ATTRITIONAL AND LARGE LOSSES IN CHAIN LADDER CALCULATIONS
Authors: Riegel Ulrich 
Published: November 2013

AbstractWe introduce a stochastic model for the development of attritional and large claims in long-tail lines of business and present a corresponding “chain ladder-like” IBNR method which allows the use of claims payment data for attritional and claims incurred data for large losses. We derive formulas for the mean squared error of prediction and apply the method to a German motor third party liability portfolio.
Implementing the Mental Health Act 2001 in Ireland: views of Irish general practitioners
Authors: Jabbar F. , Aziz M. , Kelly B. D. 
Published: November 2013

ObjectivesThe Mental Health Act 2001 introduced important reforms of Irish mental health law and services. This paper aims to provide an evidence-based exploration of general practitioners’ views on the implementation of the Mental Health Act 2001.MethodsWe posted questionnaires to 1200 general practitioners in Ireland seeking their views on their experiences with the Mental Health Act 2001.ResultsEight hundred and twenty general practitioners (68.3%) responded. Among those who provided comments, a majority (75.2%) provided negative comments. The most commonly occurring themes related to difficulties with transport of patients to inpatient facilities, form filling, time requirements and administrative matters. Other negative comments related to general practitioner recommendations for involuntary admission, training, mental health tribunals, applications for involuntary admission and the position of children. Minorities provided neutral (18.0%) or positive comments (6.8%), chiefly related to user-friendliness, transparency and improved communication.ConclusionsGeneral practitioners highlight a need for greater training and clear guidelines in relation to the Mental Health Act 2001. Their forthright responses demonstrate deep engagement with the new legislation and eagerness to see the Mental Health Act 2001 realise its full potential to improve the involuntary admission process and protect human rights, in the best interests of patients.
Investigation of the mobile granular layer in bedload transport by laminar shearing flows
Authors: Aussillous Pascale , Chauchat Julien , Pailha Mickael , Médale Marc , Guazzelli Élisabeth 
Published: November 2013

AbstractThe mobile layer of a granular bed composed of spherical particles is experimentally investigated in a laminar rectangular channel flow. Both particle and fluid velocity profiles are obtained using particle image velocimetry for different index-matched combinations of particles and fluid and for a wide range of fluid flow rates above incipient motion. A full three-dimensional investigation of the flow field inside the mobile layer is also provided. These experimental observations are compared to the predictions of a two-phase continuum model having a frictional rheology to describe particle–particle interactions. Different rheological constitutive laws having increasing degrees of sophistication are tested and discussed.
Torellian (c. 640 Ma) metamorphic overprint of Tonian (c. 950 Ma) basement in the Caledonides of southwestern Svalbard
Authors: MAJKA JAROSŁAW , BE’ERI-SHLEVIN YARON , GEE DAVID G. , CZERNY JERZY , FREI DIRK , LADENBERGER ANNA 
Published: November 2013

AbstractIon microprobe dating in Wedel Jarlsberg Land, southwestern Spitsbergen, provides new evidence of early Neoproterozoic (c. 950 Ma) meta-igneous rocks, the Berzeliuseggene Igneous Suite, and late Neoproterozoic (c. 640 Ma) amphibolite-facies metamorphism. The older ages are similar to those obtained previously in northwestern Spitsbergen and Nordaustlandet where they are related to the Tonian age Nordaustlandet Orogeny. The younger ages complement those obtained recently from elsewhere in Wedel Jarlsberg Land of Torellian deformation and metamorphism at 640 Ma. The Berzeliuseggene Igneous Suite occurs in gently N-dipping, top-to-the-S-directed thrust sheets on the eastern and western sides of Antoniabreen where it is tectonically intercalated with younger Neoproterozoic sedimentary formations, suggesting that it provided a lower Tonian basement on which upper Tonian to Cryogenian sediments (Deilegga Group) were deposited. They were deformed together during the Torellian Orogeny, prior to deposition of Ediacaran successions (Sofiebogen Group) and overlying Cambro-Ordovician shelf carbonates, and subsequent Caledonian and Cenozoic deformation. The regional importance of the late Neoproterozoic Torellian Orogeny in Svalbard's Southwestern Province and its correlation in time with the Timanian Orogeny in the northern Urals as well as tectonostratigraphic similarities between the Timanides and Pearya (northwestern Ellesmere Island) favour connection of these terranes prior to the opening of the Iapetus Ocean and Caledonian Orogeny.
Excitation of lower hybrid wave by an ion beam in magnetized plasma
Authors: Prakash Ved , Gupta Ruby , Sharma Suresh C. , Vijayshri  
Published: November 2013

AbstractLower hybrid wave excitation in magnetized plasma by an ion beam via Cerenkov interaction is studied. The lower hybrid modes showed maximum growth rate of the instability when phase velocity of the lower hybrid mode along the magnetic field is comparable to the electron thermal velocity. We have derived the expression for the maximum growth rate and found that the growth rate of the instability increases with beam density. Moreover, the maximum growth rate of the instability scales as the one-third power of the beam density. The real part of the frequency of the unstable wave increases as almost the square root of the beam energy.
Philip Bell: a champion of the Modern Movement in Northern Ireland
Authors: Larmour Paul 
Published: November 2013

Architecture in Northern Ireland in the twentieth century followed much the same pattern as elsewhere in the British Isles moving, broadly, from historic styles around the turn of the century, through a phase of Arts and Crafts activity for a decade or so, until settling down to a concentrated period of interest in Neo-Georgian styling in the 1920s and '30s. This inter-war era included, however, some examples of Modernism, primarily of an ornamented Art Deco type but occasionally of a more plain variety which ranged between Functionalism and the International Style. Examples of this type of modern architecture – characterised by flat roofs, white walls, large horizontal windows and a general avoidance of ornamentation – formed only a comparatively small part of the overall output of the period in Northern Ireland, and, for most architects who were involved, their contribution amounted to little more than a building or two; such was the prevailing tradition-bound architectural mood of the time.One architect in Northern Ireland, however, demonstrated a commitment to the Modern Movement that appears to have been greater than most. That was Philip Bell, whose name has been mentioned from time to time by various commentators, whether as a designer of Modernist houses or as the architect of one other particularly well-known building of the 1930s in Northern Ireland, the Strangford Lough Yacht Club House, which was an accomplished and stylish enough building to have been featured in the English architectural press at the time.
Relapse Situations According to Marlatt’s Taxonomy in Smokers
Authors: Piñeiro Bárbara , Becoña Elisardo 
Published: November 2013

AbstractRelapse is common during the process of giving up smoking. The aim of the present study is to explore the relapse situations, according to Marlatt’s relapse taxonomy, in a sample of 428 smokers (43.9% men and 56.1% women) who participated in a cognitive-behavior psychological treatment for quitting smoking. At the end of the treatment, 221 participants were abstinent, of whom 119 (41.2% men and 58.8% women) relapsed in the course of the 12-month follow-up, the majority in the first 3 months (69.74%). Most of the relapses were attributed to intrapersonal and environmental determinants (61.33%), the most common of which were “coping with negative emotional states” (38.65%), followed by “giving in to temptations or urges” (9.24%) and “testing personal control” (8.40%). Interpersonal determinants occurred in 38.66% of relapses, this percentage being made up mostly of “social pressure”, which was the relapse situation in 34.46% of all relapses. These results, similar to those of Marlatt’s original studies and others, contribute to improving our knowledge of the relapse situations process, with a view to interventions that may help to avoid it.
A Meta-Analysis of the Diagnostic Accuracy of the SCOFF
Authors: Botella Juan , Sepúlveda Ana Rosa , Huang Huiling , Gambara Hilda 
Published: November 2013

AbstractA meta-analysis was conducted to reach a pooled estimate of the diagnostic accuracy of the SCOFF. The 15 selected studies represented a total of 882 cases and 4350 controls. The main criterion for inclusion was that the primary study had provided diagnostic classification with both a diagnostic reference and with the SCOFF (with five items and a cut-off point of two). The pooled estimates were .80 (sensitivity) and .93 (specificity). The moderator variables gender and type of measure for the diagnostic reference (interview versus psychometric tests) account for part of the observed variability. For diagnostic references based on interviews the estimate of the efficacy improves significantly. For the studies that match this criterion the sensitivity is .882 and the specificity .925 (diagnostic odds ratio, 92.19). The main conclusion was that the five questions of the SCOFF constitute a very useful screening tool, in several languages; it is highly recommended for screening purposes.
When Is Reliance on Voluntary Approaches in Agriculture Likely to Be Effective?
Authors: Segerson Kathleen 
Published: November 2013

AbstractVoluntary approaches have been used in a variety of contexts and for a variety of purposes in agriculture, including voluntary conservation programs and product labeling. This paper provides an overview of some of the general principles that emerge from the literature on voluntary approaches and their application in agriculture. The literature suggests that, to be effective, voluntary approaches must provide sufficiently strong participation incentives to a targeted population, clearly identify standards for behavior or performance that ensure additionality and avoid slippage, and monitor outcomes. Thus, reliance on voluntary approaches in agriculture is likely to be effective only if there is sufficient market demand for certain product characteristics, significant public funds are committed to pay for voluntary actions, or the political will exists to impose regulations if voluntary approaches fail.
PSAR-Align: improving multiple sequence alignment using probabilistic sampling
Authors: Kim Jaebum , Ma Jian 
Published: November 2013

Abstract
Summary: We developed PSAR-Align, a multiple sequence realignment tool that can refine a given multiple sequence alignment based on suboptimal alignments generated by probabilistic sampling. Our evaluation demonstrated that PSAR-Align is able to improve the results from various multiple sequence alignment tools.
Availability and implementation: The PSAR-Align source code (implemented mainly in C++) is freely available for download at http://bioen-compbio.bioen.illinois.edu/PSAR-Align.
Contact: jbkim@konkuk.ac.kr or jianma@illinois.edu
Mycophenolic acid-treated dendritic cells generate regulatory CD4+ T cells that suppress CD8+ T cells’ allocytotoxicity
Authors: Kazma Ihab , Lemoine Roxane , Herr Florence , Chadet Stephanie , Meley Daniel , Velge-Roussel Florence , Lebranchu Yvon , Baron Christophe 
Published: November 2013

AbstractRegulatory T cells (Treg) play a crucial role in controlling immunity and transplant rejection. Two main groups of Treg have been described: antigen-induced Treg (iTreg) and natural Treg (nTreg). The ways to induce and the mechanisms of action of Treg subsets remained ill defined, particularly for their effects on CD8+ T cells. CD8+ T cells are major agents in the rejection of allografts; the aim of this study is to investigate the effects exerted on CD8+ T cells by human CD4+ iTreg induced by mycophenolic acid-treated dendritic cells. iTreg suppress the proliferation of CD8+ T cells by allogeneic cell–cell interaction with mature dendritic cells and irrespectively of the TCR specificity of the CD8+ T cells and cell–cell contact of iTreg with CD8+ T cells. In our model, this suppression is independent of the action of IL-10 and TGF-β1. iTreg were able to modify phenotype and inhibited IFN-γ and TNF-α secretion by CD8+ T cells. Most interestingly, iTreg inhibit the synthesis of perforin and of granzymes A and B by CD8+ T cells and impaired their cytotoxicity against allogeneic targets. In summary, our study showed the involvement of iTreg in the down-regulation of cytotoxic responses mediated by CD8+ T cells in an allospecific context. Following studies that have shown the existence of a regulation control exerted by iTreg on CD4+ T cells and dendritic cells, this work ultimately shows that this regulation can reach CD8+ T-cell functions.