bluuebunny/crossref_metadata_2025_split huggingface dataset:
Total Phenolics of Virgin Olive Oils Highly Correlate with the Hydrogen Atom Transfer Mechanism of Antioxidant Capacity
Authors: Ballus Cristiano Augusto , Meinhart Adriana Dillenburg , de Souza Campos Francisco Alberto , Godoy Helena Teixeira 
Published: March 2015

AbstractPolar extracts of extra‐virgin olive oils (EVOO) contain a large number of phenolic compounds with antioxidant properties. The antioxidant capacity can be measured by different reaction mechanisms, as the single electron transfer (SET) or the hydrogen atom transfer (HAT). In this work, the total phenolic content (TPC) by the Folin‐Ciocalteu method and its correlation with four antioxidant capacity assays (FRAP, ABTS, DPPH• and ORAC) were evaluated for EVOO polar extracts. It was observed that the higher the total phenolic compounds in the EVOO extracts, the higher the antioxidant capacities, regardless of the method employed. The reaction mechanism observed for TPC by Folin‐Ciocalteu method and also for FRAP, ABTS and DPPH• antioxidant capacity assays is a single electron transfer, thus, a high correlation among their results is expected. However, the correlation between TPC and ORAC results was also high and significant, allowing to conclude that EVOO phenolic compounds are able to react by the hydrogen atom transfer mechanism, which indicates that they can act as effective radical chain‐breaking antioxidants. These results suggest that, for the EVOO polar extracts, TPC by Folin‐Ciocalteu and ORAC assays could be sufficient to evaluate their in vitro antioxidant capacity.
Nephrites of East Siberia: geochemical features and problems of genesis
Authors: Burtseva M.V. , Ripp G.S. , Posokhov V.F. , Murzintseva A.E. 
Published: March 2015

Abstract
The largest nephrite-bearing province of Russia is located on the southern folded periphery of the Siberian craton. Deposits of two formation types were established here: apoultrabasic (East Sayan and Dzhida areas, Parama massif) and apocarbonate (Vitim area). Nephrites compose schlieren and lenticular bodies usually in the zones of contact of serpentinous (lizardite–antogorite) dunite–harzburgite rocks and dolomitic marbles with aluminosilicate rocks of different compositions. Significant difference in composition has been established for nephrites of different formations. Apocarbonate nephrites are more magnesian and fluoric and less ferroan. The contents of Li, Be, Rb, and Cs in them are two orders of magnitude higher and the contents of Sc, Ti, and Mn are lower than those in apoultrabasic nephrites. The isotope data evidence that the fluid phase of apoultrabasic nephrites was released from serpentinites during metamorphism, whereas the fluid phase of apocarbonate nephrites is only meteoric water. Oxygen in minerals of metamorphosed carbonate rocks was borrowed from the matrix subjected to replacement, sometimes with the participation of formation waters.
The Dovyren intrusive complex (northern Baikal region, Russia): isotope–geochemical markers of contamination of parental magmas and extreme enrichment of the source
Authors: Ariskin A.A. , Danyushevsky L.V. , Konnikov E.G. , Maas R. , Kostitsyn Yu.A. , McNeill A. , Meffre S. , Nikolaev G.S. , Kislov E.V. 
Published: March 2015

Abstract
The Dovyren intrusive complex includes the ore-bearing (Cu–Ni–PGE) Yoko–Dovyren layered pluton (728 Ma, up to 3.4 km in thickness), underlying ultramafic sills, and comagmatic leuconorite and gabbro-diabase dikes. Studies of Sr–Nd–Pb isotope systems were carried out for 24 intrusive rocks and five associated low- and high-Ti basalts. The high-Ti basalts show 0.7028 ≤ (87Sr/86Sr)T ≤ 0.7048 and 4.6 ≤ εNd(T) ≤ 5.8, similar to the values in MORB. The intrusive basic and ultrabasic rocks are geochemically similar to the low-Ti formation, making a compact cluster of compositions with extremely high ratios of radiogenic Sr and Pb isotopes and low εNd values. The maximum enrichment in radiogenic Sr is shown by the rocks near the pluton bottom ((87Sr/86Sr)T = 0.71387 ± 0.00010 (2σ); εNd(T) = –16.09 ± 0.06), which are the products of crystallization of the most primitive high-Mg magmas. The above-located dunites, troctolites, and gabbro show lower enrichment, probably because of the contamination of the host rocks during the filling of the magma chamber and/or because of the slight heterogeneity of the source. Calculations of the proportions of mixing of the parental melt with carbonate terrigenous material have shown that the variations in the Sr and Nd isotope ratios are due to the incredibly high contamination of the sediments, up to 40–50%. This contradicts the succession of the main rock types in the Yoko–Dovyren pluton in accordance with the crystallization of picrite-basaltic magma. The contribution of 5–10% high-Ti component seems more likely and suggests interaction between two isotopically contrasting magmas in this province in the Late Riphean. In general, the minor variations in εNd(T) of the intrusive rocks and metavolcanics (–14.3 ± 1.1) testify to the isotopically anomalous source of the low-Ti magmas. The time variation trend of εNd and geochemical features of the Dovyren rocks indicate that the products of melting of 2.7–2.8 Ga suprasubduction mantle might have been the massif protolith. Thus, the Dovyren parental magmas formed from a much older (sub)lithospheric source in the Late Riphean. The source was initially enriched in a mafic component with a low Sm/Nd ratio and was isolated from the convecting mantle and mantle melting processes for ~2 Gyr. The existence of such a long-living and at least twice reactivated lithospheric substratum is confirmed by the fact that the Nd isotope evolution trend of the initially nonanomalous mantle protolith includes not only the Dovyren rocks but also the Paleoproterozoic gabbro of the Chinei pluton and the Archean enderbites of the Baikal region.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
The behavior of ore elements in oxidized heterophase chloride and carbonate–chloride–sulfate fluids of porphyry Cu–Mo(Au) deposits (from experimental data)
Authors: Borovikov A.A. , Bul’bak T.A. , Borisenko A.S. , Ragozin A.L. , Palesskii S.V. 
Published: March 2015

Abstract
The spatial coexistence and synchronous formation of magmatogene porphyry Cu–Mo mineralization and epithermal gold mineralization are due to the genetic relationship between their formation processes. This relationship might be due to the generation of metal-bearing fluids of different geochemical compositions by the porphyry ore-magmatic system, which then participate in the formation of magmatogene porphyry Cu–Mo(Au) and associated epithermal gold deposits. Synthesis of fluid inclusions in quartz was performed for experimental study of the behavior of Cu, Mo, W, Sn, Au, As, Sb, Te, Ag, and Bi in heterophase fluids similar in composition and aggregate state to natural ore-forming fluids of porphyry Cu–Mo(Au) deposits. We have established that at 700 ºC, a pressure decrease from 117 to 106 MPa leads to a significant enrichment of the gas phase of heterophase chloride fluid with Au, As, Sb, and Bi. The heterophase state of carbonate–chloride–sulfate fluids is observed at 600 ºC and 100–90 MPa. It characterizes the highly concentrated liquid carbonate–sulfide phase–liquid chloride phase–low-density gas phase equilibrium. A decrease in the pressure of heterophase carbonate–chloride–sulfate fluid leads to a noticeable enrichment of its chloride phase with Cu, Mo, Fe, W, Ag, Sn, Sb, and Zn relative to the carbonate–sulfate phase. The processes of redistribution of ore elements between the phases of heterophase fluids can be considered a model of generation of metal-bearing chloride fluids, which occurs in nature during the formation of porphyry Cu–Mo(Au) deposits, as well as a model of generation of gas fluids supplying Au, Te, As, and other ore elements to the place of formation of epithermal Au–Cu and Au–Ag mineralization.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
Correlation of well logs as a multidimensional optimization problem
Authors: Lapkovsky V.V. , Istomin A.V. , Kontorovich V.A. , Berdov V.A. 
Published: March 2015

Abstract
We consider a variant of automatic correlation between well sections based on construction of multidimensional functions of differences between fragments of logs. The solution is obtained either by successive correlation between the boundaries based on the projective model of Haites and definition of the boundary position at the minimum of the difference function or by construction of the lines of optimal trajectories on a 2D Zhekovskii’s plot. These algorithms are implemented as a program package for original interpretation of well data and as a plug-in for the automatic correlation module of the Schlumberger Petrel software using the Ocean development tools.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
Relationship of the thermal conductivity of rocks in the Komsomol’sk ore district (Khabarovsk Territory) with minerageny and metasomatism
Authors: Gornov P.Yu. 
Published: March 2015

Abstract
Statistical data are given on the thermal conductivity of rocks in the Komsomol’sk ore district (Khabarovsk Territory). The regularities of variations in the thermal-conductivity and thermal-inhomogeneity factors of the studied types of rocks are considered in relation to their mineral composition, texture, structure, and degree of metasomatic alteration. Thermophysical sections of the studied mineralized zones are presented. The conclusion is substantiated that the thermal properties of rocks are highly informative and detailed thermophysical studies of sections might be useful for their lithological subdivision.
© 2015, V.S. Sobolev IGM, Siberian Branch of the RAS. Published by Elsevier B.V. All rights reserved.
Gait and speed selection in slender inertial swimmers
Authors: Gazzola Mattia , Argentina Médéric , Mahadevan L. 
Published: March 2015

Significance
Swimming relies on linking internal neural dynamics to body mechanics and environmental hydrodynamics. To characterize this in an integrative setting we present a minimal theoretical framework that synthesizes the roles of passive body elasticity, hydrodynamics, muscular activation, and proprioceptive sensory feedback in inertial swimmers. Our findings quantitatively explain a range of classic experimental observations linking gait and speed in a range of swimming fish. Our calculations also yield a mechanism for how elastohydrodynamic resonances lead to optimal gait selection. Finally, we show that a self-organized propulsive gait can be achieved via a proprioceptive mechanism wherein local muscle activation is driven by shape change, without the need for a central pattern generator, suggestive of ways to engineer robotic swimmers.
‘From the Housewife’s Point of View’: Female Citizenship and the Gendered Domestic Interior in Post-First World War Britain, 1918–1928.
Authors: Cowman Krista 
Published: March 2015

Abstract
This article explores the work of the Women’s Housing Sub-Committee, a government-appointed body which reported to the Advisory Council of the Ministry of Reconstruction, in recognising the home as a key site where active, respectable female citizens might be produced. The Sub-Committee started work in 1918, a month after the Representation of the People Act gave votes to some British women, prompting a wide debate about how best to integrate them into political life. Charged with reporting on plans for post-war social housing in England and Wales, the Sub-Committee demanded that these homes should be designed from the point of view of the working-class housewife who would occupy them. Through considering the evidence gathered by the Sub-Committee and its responses to the plans suggested by Ministry architects, the paper demonstrates how the sub-committee demanded new spatial configurations that would afford women citizens the space they needed to think and discuss politics while new labour-saving devices–and the room to house them–would free up time for them to develop themselves as active citizens. Finally, it considers how this connection was pursued in the discourse of the three main political parties as they attempted to connect with the rising numbers of women voters in the decade between women’s partial and full enfranchisement.
Switching from tenofovir to abacavir in HIV-1-infected patients with low bone mineral density: changes in bone turnover markers and circulating sclerostin levels
Authors: Negredo Eugènia , Diez-Pérez Adolfo , Bonjoch Anna , Domingo Pere , Pérez-Álvarez Núria , Gutierrez Mar , Mateo Gracia , Puig Jordi , Echeverría Patricia , Escrig Roser , Clotet Bonaventura 
Published: March 2015

Abstract

Background
Tenofovir is involved in accelerated bone mineral density (BMD) loss.

Methods
We recently published a hip BMD improvement at week 48 [+2.1% (95% CI: −0.6, 4.7) (P = 0.043)] in HIV-infected patients with osteopenia/osteoporosis randomized to switch from tenofovir to abacavir (n = 26), although without reaching statistical significance compared with those who maintained tenofovir (n = 28). Here, we present changes at week 48 in bone markers [C-terminal telopeptide of collagen type 1 (CTX), osteocalcin and procollagen type 1 N propeptide (P1NP)] as well as in circulating levels of three proteins involved in bone regulation [osteoprotegerin, receptor activator for NF-κB ligand (RANKL) and sclerostin, a selective regulator of bone formation through the Wnt pathway] in 44 of these patients. χ2 or Fisher and Student t-tests were performed according to the distribution of the variables.

Results
Bone markers decreased only in the abacavir group [mean (SD) CTX changed from 0.543 (0.495) to 0.301 (0.306) ng/mL; mean (SD) osteocalcin changed from 23.72 (22.20) to 13.95 (12.40) ng/mL; and mean (SD) P1NP changed from 54.68 (54.52) to 28.65 (27.48) ng/mL (P &lt; 0.001 in all cases)], reaching statistical significance between the groups at week 48. Osteoprotegerin did not vary, but sclerostin significantly increased in the abacavir group [from 29.53 (27.91) to 35.56 (34.59) pmol/L, P = 0.002]. No significant differences in osteoprotegerin and sclerostin were detected between the groups at week 48. RANKL values were below the limit of detection in all samples.

Conclusions
The switch from tenofovir to abacavir seems to induce a positive effect on bone tissue, since bone turnover markers decreased. In addition, circulating sclerostin levels increased, a change associated with improved bone properties.
Leveraging the NLM map from SNOMED CT to ICD-10-CM to facilitate adoption of ICD-10-CM
Authors: Cartagena F Phil , Schaeffer Molly , Rifai Dorothy , Doroshenko Victoria , Goldberg Howard S 
Published: March 2015

Abstract
Objective Develop and test web services to retrieve and identify the most precise ICD-10-CM code(s) for a given clinical encounter. Facilitate creation of user interfaces that 1) provide an initial shortlist of candidate codes, ideally visible on a single screen; and 2) enable code refinement.
Materials and Methods To satisfy our high-level use cases, the analysis and design process involved reviewing available maps and crosswalks, designing the rule adjudication framework, determining necessary metadata, retrieving related codes, and iteratively improving the code refinement algorithm.
Results The Partners ICD-10-CM Search and Mapping Services (PI-10 Services) are SOAP web services written using Microsoft's.NET 4.0 Framework, Windows Communications Framework, and SQL Server 2012. The services cover 96% of the Partners problem list subset of SNOMED CT codes that map to ICD-10-CM codes and can return up to 76% of the 69 823 billable ICD-10-CM codes prior to creation of custom mapping rules.
Discussion We consider ways to increase 1) the coverage ratio of the Partners problem list subset of SNOMED CT codes and 2) the upper bound of returnable ICD-10-CM codes by creating custom mapping rules. Future work will investigate the utility of the transitive closure of SNOMED CT codes and other methods to assist in custom rule creation and, ultimately, to provide more complete coverage of ICD-10-CM codes.
Conclusions ICD-10-CM will be easier for clinicians to manage if applications display short lists of candidate codes from which clinicians can subsequently select a code for further refinement. The PI-10 Services support ICD-10 migration by implementing this paradigm and enabling users to consistently and accurately find the best ICD-10-CM code(s) without translation from ICD-9-CM.
Case-based reasoning using electronic health records efficiently identifies eligible patients for clinical trials
Authors: Miotto Riccardo , Weng Chunhua 
Published: March 2015

AbstractObjective To develop a cost-effective, case-based reasoning framework for clinical research eligibility screening by only reusing the electronic health records (EHRs) of minimal enrolled participants to represent the target patient for each trial under consideration.Materials and Methods The EHR data—specifically diagnosis, medications, laboratory results, and clinical notes—of known clinical trial participants were aggregated to profile the “target patient” for a trial, which was used to discover new eligible patients for that trial. The EHR data of unseen patients were matched to this “target patient” to determine their relevance to the trial; the higher the relevance, the more likely the patient was eligible. Relevance scores were a weighted linear combination of cosine similarities computed over individual EHR data types. For evaluation, we identified 262 participants of 13 diversified clinical trials conducted at Columbia University as our gold standard. We ran a 2-fold cross validation with half of the participants used for training and the other half used for testing along with other 30 000 patients selected at random from our clinical database. We performed binary classification and ranking experiments.Results The overall area under the ROC curve for classification was 0.95, enabling the highlight of eligible patients with good precision. Ranking showed satisfactory results especially at the top of the recommended list, with each trial having at least one eligible patient in the top five positions.Conclusions This relevance-based method can potentially be used to identify eligible patients for clinical trials by processing patient EHR data alone without parsing free-text eligibility criteria, and shows promise of efficient “case-based reasoning” modeled only on minimal trial participants.
Examining the Feasibility of a Simple Intervention to Improve Blood Pressure Control for Primary Care Patients
Authors: Nguyen Giang T. , Klusaritz Heather A. , O’Donnell Alison , Kaye Elise M. , de Vries McClintock Heather F. , Hussain Zehra , Bogner Hillary R. 
Published: March 2015

Background:
Blood pressure control remains a challenge despite the availability of effective antihypertensive agents.

Objective:
This pilot study explored the feasibility of a simple, low-resource intervention to improve blood pressure control.

Methods:
A convenience sample was drawn of 56 patients with hypertension from a primary care clinic. A preintervention-postintervention delivered by medical assistants involved prompts to providers to address blood pressure control with a visual aid indicating patients’ current and target blood pressure in the context of a traffic light.

Results:
Patients showed a significant reduction in mean systolic blood pressure (preintervention, 141.5 mm Hg, vs postintervention, 133.0 mm Hg; P = .002) and mean diastolic blood pressure (preintervention, 83.4 mm Hg, vs postintervention, 80.4 mm Hg; P = .049).

Conclusion:
In this pilot study, we established the feasibility of a brief, simple intervention to improve blood pressure control implemented by existing primary care practice clinical support staff, and preliminary data show that it can be effective in improving blood pressure control.
Phosphorylation of Trihelix Transcriptional Repressor ASR3 by MAP KINASE4 Negatively Regulates Arabidopsis Immunity
Authors: Li Bo , Jiang Shan , Yu Xiao , Cheng Cheng , Chen Sixue , Cheng Yanbing , Yuan Joshua S. , Jiang Daohong , He Ping , Shan Libo 
Published: March 2015

Abstract
Proper control of immune-related gene expression is crucial for the host to launch an effective defense response. Perception of microbe-associated molecular patterns (MAMPs) induces rapid and profound transcriptional reprogramming via unclear mechanisms. Here, we show that ASR3 (ARABIDOPSIS SH4-RELATED3) functions as a transcriptional repressor and plays a negative role in regulating pattern-triggered immunity (PTI) in Arabidopsis thaliana. ASR3 belongs to a plant-specific trihelix transcription factor family for which functional studies are lacking. MAMP treatments induce rapid phosphorylation of ASR3 at threonine 189 via MPK4, a mitogen-activated protein kinase that negatively regulates PTI responses downstream of multiple MAMP receptors. ASR3 possesses transcriptional repressor activity via its ERF-associated amphiphilic repression motifs and negatively regulates a large subset of flg22-induced genes. Phosphorylation of ASR3 by MPK4 enhances its DNA binding activity to suppress gene expression. Importantly, the asr3 mutant shows enhanced disease resistance to virulent bacterial pathogen infection, whereas transgenic plants overexpressing the wild-type or phospho-mimetic form of ASR3 exhibit compromised PTI responses. Our studies reveal a function of the trihelix transcription factors in plant innate immunity and provide evidence that ASR3 functions as a transcriptional repressor regulated by MAMP-activated MPK4 to fine-tune plant immune gene expression.
Family Nurture Intervention in preterm infants alters frontal cortical functional connectivity assessed by EEG coherence
Authors: Myers MM , Grieve PG , Stark RI , Isler JR , Hofer MA , Yang J , Ludwig RJ , Welch MG 
Published: March 2015

AbstractAimTo assess the impact of Family Nurture Intervention (FNI) on cortical function in preterm infants at term age.MethodsFamily Nurture Intervention is a NICU‐based intervention designed to establish emotional connection between mothers and preterm infants. Infants born at 26–34 weeks postmenstrual age (PMA) were divided into two groups, standard care (SC, N = 49) and FNI (FNI, N = 56). Infants had EEG recordings of ~one hour duration with 124 lead nets between 37 and 44 weeks PMA. Coherence was measured between all pairs of electrodes in ten frequency bands. Data were summarised both within and between 12 regions during two sleep states (active, quiet).ResultsCoherence levels were negatively correlated with PMA age in both groups. As compared to SC infants, FNI infants showed significantly lower levels of EEG coherence (1–18 Hz) largely within and between frontal regions.ConclusionCoherence in FNI infants was decreased in regions where we previously found robust increases in EEG power. As coherence decreases with age, results suggest that FNI may accelerate brain maturation particularly in frontal brain regions, which have been shown in research by others to be involved in regulation of attention, cognition and emotion regulation; domains deficient in preterm infants.