bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Crosstown Initiative: Art, Community, and Placemaking in Memphis
Authors: Thomas Elizabeth , Pate Sarah , Ranson Anna 
Published: December 2014

AbstractThis case study examines an arts organization at the center of an urban neighborhood revitalization effort and its contributions to creative placemaking and inclusive community building. The study documents innovative arts practices and explores their meaning for a local context, an understudied city in the Mid‐South region of the United States. It builds on the research team’s ongoing work as teachers, students, and scholars in partnership with the arts organization. It includes systematic participant observation, interviews with stakeholders, and a review of historical and contemporary media coverage. We found that the organization and its practices provided a rich context for exploring an expanded sense of community including bridging social capital and place‐based frameworks. Analysis suggests that the organization’s intentional arts based practices bring multiple understandings of community and art into meaningful dialogue through the generation of creative and social friction. These practices illustrate one context‐specific strategy addressing the tensions in a community–diversity dialectic (Townley et al. in Am J Commun Psychol 47:69–85, 2011).
Clinical Outcomes following Collagenase Injections Compared to Fasciectomy in the Treatment of Dupuytren's Contracture
Authors: Muppavarapu Raghuveer C. , Waters Michael J. , Leibman Matthew I. , Belsky Mark R. , Ruchelsman David E. 
Published: December 2014

Introduction The aim of this study is to compare the efficacy of collagenase injections with that of fasciectomy in the treatment of Dupuytren's contracture. Methods This is a case–control retrospective study. We reviewed the electronic medical records from January 2009 through January 2013, identifying 142 consecutive patients who underwent either fasciectomy or collagenase injection. Exclusion criteria for both groups were age <18 years, pregnant women, and arthroplasty or arthrodesis of the treated joint. Follow-up data beyond 1-year duration was available for 117 of the patients: 44 patients who had undergone fasciectomy, and 73 patients who had received collagenase injection. The primary outcome measure in this study was resolution of joint contracture to 0–5° deficit of full extension. Data was analyzed using two-sample t tests for continuous data and chi-square test for categorical data. A significant P value was set at <0.05. Results At the latest follow-up, significantly more joints treated with fasciectomy met the primary outcome measure. Metacarpophalangeal (MP) joints responded better than the proximal interphalangeal (PIP) joints for both treatments. At the latest follow-up (14.2 months for collagenase, 16.3 months for fasciectomy), 46 % of MP joints treated with collagenase and 68 % of MP joints treated with fasciectomy maintained resolution of joint contracture. Sub-analysis of the affected joints based on the severity of initial contracture demonstrated that MP and PIP joints with contractures <45° responded better than more severely contracted joints (>45°). Conclusions Fasciectomy yields a greater mean magnitude of correction for digital contractures at the latest follow-up when compared to collagenase. Both treatments were more effective for treatment of MP joint contracture compared to PIP joint contracture. Level of Evidence Level III, therapeutic.
Präimplantationsdiagnostik
Authors: Hehr Andreas , Frister Helmut , Fondel Sabine , Krauß Susann , Zuehlke Christine , Hellenbroich Yorck , Hehr Ute , Gillessen-Kaesbach Gabriele 
Published: December 2014

Zusammenfassung
Für Paare mit hohem Risiko der Nachkommen für eine monogen-erbliche oder chromosomal-bedingte Erkrankung kann die Präimplantationsdiagnostik (PID) heute eine Option einer verantwortlichen Familienplanung sein. Voraussetzung für eine PID ist die Befruchtung von Eizellen im Reagenzglas (In-vitro-Fertilisation, IVF). Die Behandlungsergebnisse entsprechen weitgehend denen einer normalen Kinderwunschbehandlung mit intrazytoplasmatischer Spermieninjektion (ICSI) ohne PID. Die Grenzen und Chancen, aber auch der hohe Aufwand, sind frühzeitig und ergebnisoffen in einer interdisziplinären Beratung zu thematisieren, um dem Paar eine informierte Entscheidung und Abwägung der PID gegenüber anderen Alternativen im Rahmen der Familienplanung zu ermöglichen.
In diesem Beitrag werden der aktuelle internationale Kenntnisstand zur PID, einschließlich ihrer verschiedenen Anwendungsbereiche, sowie mögliche zukünftige Entwicklungen vorgestellt. Breiten Raum nimmt der rechtliche Rahmen für die eng begrenzte Durchführung einer PID in Deutschland ein, der durch den Deutschen Bundestag mit der Verabschiedung des Gesetzes zur Regelung der Präimplantationsdiagnostik (Präimplantationsdiagnostikgesetz, PräimpG) 2011 und der nachfolgenden Rechtsverordnung 2012 definiert wurde. Abschließend wird der derzeitige Stand der Umsetzung in Deutschland skizziert und eine nationale Koordination und Vernetzung der PID-Zentren angeregt, um zeitnah unter optimaler Nutzung der Ressourcen und Erfahrungen für ein möglichst breites Spektrum an seltenen Erkrankungen eine qualitätsgesicherte PID in Deutschland anbieten zu können.
How are pluripotent cells captured in culture?
Authors: Kinoshita Masaki 
Published: December 2014

AbstractIn mice, three pluripotent stem cell lines have been established from different stage of developing embryo, which are embryonic stem (ES) cell, post‐implantation epiblast stem cell (EpiSC), and embryonic germ (EG) cell. ES cell and EG cell share many common features including factor requirement, colony morphology, and gene expression pattern. On the other hand, EpiSC needs different external signal inputs, exhibits flattened colony morphology, and a different set of gene expression patterns. In addition, the germ line competency of EpiSCs is still unclear. To distinguish the differences between them, they are defined by the words “naïve” and “primed” pluripotent cells, respectively. This article introduces how pluripotent stem cell lines are established in culture, and how much those cells in vitro are similar or relevant to their in vivo origin and the knowledge about transcription factors to support this state.
Treatment of Postherpetic Neuralgia Using a Thoracic Transforaminal Epidural Steroid Injection
Authors: Mehta Priyesh , Maher Patrick , Singh Jaspal Ricky 
Published: December 2014

AbstractA 64‐year‐old male patient with a history of herpes zoster exposure presented with severe, constant, burning pain in the left T10 dermatome consistent with postherpetic neuralgia. Previous treatment included oral and topical medications as well as an intercostal nerve block; however, these treatment options did not provide significant relief. The patient was treated with a single‐level T10 thoracic transforaminal epidural steroid injection for refractory postherpetic neuralgia. He reported complete resolution of his symptoms at 2‐ and 12‐week follow‐ups. This case illustrates transforaminal epidural steroid injections may be a successful treatment option for postherpetic neuralgia.
African Women’s Movements in the Twentieth Century: A Hidden History
Authors: Berger Iris 
Published: December 2014

Abstract:This article begins by exploring the efforts of African women’s movements from the 1990s onward to end violent civil conflicts and to insist on guarantees of gender equity in newly formed governments. It attempts to explain these recent successes first by examining the complex relationships between international women’s movements and African women’s groups from the Second World War onward, particularly from the era of the U.N. Decade for Women beginning in 1975. The article then turns to a broader problem: exploring the connections between contemporary women’s activism and deeper currents in African history that link the precolonial period with the more recent past. By examining a variety of twentieth-century women’s protests, it argues that cloaked in the language of political, economic, and environmental grievances, these movements also reflect a hidden history of women’s influence as public healers, empowered not only to cure individuals, but also to mend broader relationships in the community.
Reversals of Exile: Williams Sassine’sWirriyamuand Tierno Monénembo’sPelourinho
Authors: Small Audrey 
Published: December 2014

Abstract:This essay examines two novels by exiled Guinean writers in which physical space functions as a central point of reference for very different, though related, considerations of traumatized memory, identity, and exile. In Williams Sassine’sWirriyamu(1976), a violent and violated rural landscape becomes emblematic of a specific traumatic event occurring within the time frame of the novel and of contemporary political reality; while in Tierno Monénembo’sPelourinho(1995), a present-day cityscape provides consistently uncertain territory for thinking through a trauma that transcends history, that of the transatlantic slave trade. This article seeks to examine some of the ways in which contemporary trauma theory may be useful in reading Francophone West African fiction as well as some of the limitations of this theory in its applications to this corpus.
Let's talk about you and me
Authors: ZEIJLSTRA HEDDE 
Published: December 2014

A recent development in Dutch concerns the deictic interpretation of the second-person singular pronounje, which may refer to the speaker only. In such examples the subject refers to the speaker – not the hearer – but at the same time, these examples come along with an implicature stating that the hearer would have done the same thing if s/he were in the speaker's situation. Why is it the case that a second-person singular pronoun may refer to the speaker only? And why is it that when speaker-referringjeis used, it always comes along with an implicature of the kind described above? In this article I argue that this behavior of Dutchjeis a consequence of its semantically unmarked status with respect to the first-person singular pronounik. Along the lines of Sauerland (2008), I propose that Dutchjeonly carries one feature, [PARTICIPANT], whereasikcarries two features: [SPEAKER] and [PARTICIPANT]. Consequently,jemay in principle refer to all participants in the conversation, enablingjeto refer to the speaker as well. The fact thatjedoes not normally refer to the speaker but to the hearer only then follows as some kind of blocking effect resulting from application of the principle of Maximize Presupposition. The paper concludes by spelling out the predictions that this analysis makes for the cross-linguistic variation with respect to the readings that participant and other pronouns may yield.
NIPPV: Prevalence, Approach and Barriers to Use at Canadian ALS Centres
Authors: Ritsma Benjamin R. , Berger Michael J. , Charland David A. , Khoury Michael A. , Phillips Joel T. , Quon Michael J. , Strong Michael J. , Schulz Valerie M. 
Published: December 2014

Objective:The purpose of this study was to evaluate Canadian amyotrophic lateral sclerosis (ALS) centres with respect to: 1) the prevalence of Non-invasive positive pressure ventilation (NIPPV) and invasive mechanical ventilation via tracheostomy (TV) utilization, 2) the approach to NIPPV use, focusing upon the currently employed initiation criteria and 3) the barriers influencing NIPPV administration.Methods:A descriptive survey research design aimed to obtain quantitative data and open-ended responses from an active physician at each of the 15 multidisciplinary Canadian ALS centres.Results:The principal findings of this study were: 1) NIPPV and TV are used in 18.3% and 1.5% of patients at Canadian ALS centres, respectively, 2) symptoms of respiratory insufficiency, namely orthopnea (clinical significance rated at 9.00/10 ± 1.48), dyspnea (8.27 ± 1.95) and morning headache (7.55 ± 1.21) are the most significant indicators for NIPPV initiation, 3) the primary barriers to NIPPV utilization are patient intolerance (70% of centres) and inaccessibility of respirologists and ventilation technologists (50% of centres).Conclusions:Variability in NIPPV use has an impact upon the management of Canadian ALS patients. The establishment of more definitive NIPPV initiation criteria, emphasizing respiratory symptoms, and the attenuation of barriers to NIPPV use should be targeted so as to ensure optimal care for all ALS patients.
Depression in Parkinson's Disease
Authors: Jasinska-Myga Barbara , Putzke John D. , Wider Christian , Wszolek Zbigniew K. , Uitti Ryan J. 
Published: December 2014

Objective:To examine predictive factors associated with onset of depression among individuals diagnosed with Parkinson's disease (PD).Background:Depression may precede or follow symptomatic parkinsonism in PD. It is frequently treatable but often overlooked.Methods:The clinical series comprised 685 individuals who were diagnosed with PD and followed by one neurologist (RJU) from 1994 to 2007. The primary outcome was time to depression following the onset of PD. Diagnosis of depression was based on clinical assessment of depressive symptoms from patients (and spouse/family/caregiver) and antidepressant usage. A number of demographic, historical and clinical predictive factors were examined, including gender, age at symptomatic onset, disease duration, onset characteristics, clinical ratings, antiparkinsonian medications, cognitive status, depression history, and familial history of PD and other neurodegenerative disorders.Results:Seventy-two percent of patients developed depression within ten years of symptomatic PD onset, and the mean time to depression was 7.9 years (median: 5.7 years). Factors associated with depression included longer PD duration, greater impairment in activities of daily living, and positive family history of motor neuron disease (MND).Conclusions:A high rate of individuals with PD develop depressive symptoms during the course of the disease. Based on first clinic visit characteristics, most factors examined were not helpful in identifying individuals with an increased risk of depression. However, disease duration, functional limitations and family history of MND should lead clinicians to an increased vigilance for identifying depression.
Deregulated Expression of the Per1 and Per2 in Human Gliomas
Authors: Xia He-chun , Niu Zhan-feng , Ma Hui , Cao Shuan-zhu , Hao Shao-cai , Liu Zhong-tao , Wang Fan 
Published: December 2014

Background:Growing evidence shows that the deregulation of the circadian clock plays an important role in the development of malignant tumors, including gliomas. However, the molecular mechanisms of genes controlling circadian rhythm in glioma cells have not been explored.Methods:Using reverse transcription polymerase chain reaction and immunohistochemistry techniques, we examined the expression of two important clock genes, Per1 and Per2, in 33 gliomas.Results:In this study, out of 33 gliomas, 28 were Per1-positive, and 23 were Per2-positive. The expression levels of Per1 and Per2 in glioma cells were significantly different from the surrounding non-glioma cells (P<0.01). The difference in the expression rate of Per1 and Per2 in high-grade (grade III and IV) and low-grade (grade 1 and II) gliomas was insignificant (P>0.05). While there was no difference in the intensity of immunoactivity for Per2 between high-grade gliomas and low-grade gliomas (r=-0.330, P=0.061), the expression level of Per1 in highgrade gliomas was significantly lower than that in low-grade gliomas(r=-0.433, P=0.012).Conclusions:In this study, we found that the expression of Per1 and Per2 in glioma cells was much lower than in the surrounding non-glioma cells. Therefore, we suggest that disturbances in Per1 and Per2 expression may result in the disruption of the control of normal circadian rhythm, thus benefiting the survival of glioma cells. Differential expression of circadian clock genes in glioma and non-glioma cells may provide a molecular basis for the chemotherapy of gliomas.
Reproducibility of Semi-Automated Measurement of Carotid Stenosis on CTA
Authors: White Jeremy H. , Bartlett Eric S. , Bharatha Aditya , Aviv Richard I. , Fox Allan J. , Thompson Andrew L. , Bitar Richard , Symons Sean P. 
Published: December 2014

Purpose:To compare the reproducibility of semi-automated vessel analysis software to manual measurement of carotid artery stenosis on computed tomography angiography (CTA).Methods:Two observers separately analyzed 81 carotid artery CTAs using semi-automated vessel analysis software according to a blinded protocol. The software measured the narrowest stenosis in millimeters (mm), distal internal carotid artery (ICA) in mm, and calculated percent stenosis based on NASCET criteria. One observer performed this task twice on each carotid, the second analysis delayed two months in order to mitigate recall bias. Two other observers manually measured the narrowest stenosis in mm, distal ICA in mm, and calculated NASCET percent stenosis in a blinded fashion. Correlation coefficients were calculated for each group comparing the narrowest stenosis in mm, distal ICA in mm, and NASCET percent stenosis.Results:The semi-automated vessel analysis software provided excellent intraobserver correlation for narrowest stenosis in mm, distal ICA in mm, and NACSET percent stenosis (Pearson correlation coefficients of 0.985, 0.954, and 0.977 respectively). The semi-automated vessel analysis software provided excellent interobserver correlation (0.925, 0.881, and 0.892 respectively). The interobserver correlation for manual measurement was good (0.595, 0.625, and 0.555 respectively). There was a statistically significant difference in the interobserver correlation between the semi-automated vessel analysis software observers and the manual measurement observers (P < 0.001).Conclusion:Semi-automated vessel analysis software is a highly reproducible method of quantifying carotid artery stenosis on CTA. In this study, semi-automated vessel analysis software determination of carotid stenosis was shown to be more reproducible than manual measurement.
Botulinum Toxin Type A and Acute Drug Costs in Migraine with Triptan Overuse
Authors: Christie Suzanne N. , Giammarco Rose , Gawel Marek , Mackie Gordon , Gladstone Jonathan , Becker Werner J. 
Published: December 2014

Background:Patients with chronic migraine and medication overuse are significant consumers of health care resources.Objective:To determine whether botulinum toxin type A prophylaxis reduces the cost of acute migraine medications in patients with chronic migraine and triptan overuse.Methods:In this multicenter, open-label study, patients with chronic migraine (≥15 headache days/month) who were triptan overusers (triptan intake ≥10 days/month for ≥3 months) received botulinum toxin type A (95-130 U) at baseline and month three. Headache (HA) frequency and medication use were assessed with patient diaries, and headache-related disability by means of the MIDAS and Headache Impact Test-6 questionnaires.Results:Of 53 patients enrolled (mean age ± standard deviation, 46.5 years ± 8.4; 47 [88.7%] females), 48 (90.6%) completed the study at month six. Based on headache diaries, significant (P≤0.0002) decreases from baseline were observed for days per month with headache/migraine, days with any acute headache medication use, days with triptan use, and triptan doses taken per month. A significant (P<0.0001) increase from baseline in headache-free days per month was also observed. Prescription medication costs for acute headache medications decreased significantly, including significant reductions in triptan costs (mean reduction of -C$106.32 ± 122.87/month during botulinum toxin type A prophylaxis; P<0.0001). At baseline, 78% of patients had severe disability (MIDAS score) and 86.8% had severe impact due to headache (HIT-6 scores); at month six, this decreased to 60% and 68%, respectively.Conclusions:Botulinum toxin type A prophylactic therapy markedly decreased costs related to acute headache medication use in patients with chronic migraine and triptan overuse.
Prevalence of Glaucoma in Hospitalized Older Adults with Alzheimer's Disease
Authors: Pelletier Andrée-Anne , Théorêt Marie-Ève , Boutin Tanguy , Kergoat Marie-Jeanne , Massoud Fadi , Latour Judith , Chayer Céline , Kergoat Hélène 
Published: December 2014

Objective:To determine the prevalence of glaucoma in older adults with dementia of the alzheimer's type (DAT).Methods:retrospective chart review: the prevalence of glaucoma was determined in older adults with a diagnosis of DAT or mixed dementia (DAT with vascular contribution) admitted to the geriatric and neurology units of the Centre hospitalier de l'université de Montréal and the hôpital Maisonneuve-rosemont between april 2008 and april 2009 (n=220; DAT group). they were matched for age and date of hospitalisation to the first 220 individuals without dementia (control group) recruited from other medical units in the same hospitals: gastroenterology, internal medicine or cardiology. a diagnosis of glaucoma was deemed positive if recorded in the chart or if there was a medication compatible with this diagnosis. Chi-square tests were used for between-group comparisons.Results:Subjects' age ranged from 66 to 101 years. the prevalence of glaucoma was 6.8% in our study population (n=30/440). glaucoma was significantly more prevalent in the DAT group (n= 21; 9.5%) than in the control group (n= 9; 4.1%) [χ1 2 = 5.15; p = 0.023].Conclusions:the prevalence of glaucoma was higher in a group of older adults with DAT than in a comparable control group. these results underscore the importance of providing regular eyecare for persons affected by DAT.
Temporal Lobectomy with Delayed Amnesia Following a New Lesion on the Other Side
Authors: Salmon Andrea , Hayman-Abello Brent , Connolly Barbara , McLachlan Richard S. 
Published: December 2014

Purpose:To describe a delayed severe complication of temporal lobectomy for intractable epilepsy.Method:A case of amnesia occurring 24 years after surgery is described and five similar cases from the literature reviewed.Results:Mean age at surgery (5 right) was 40 years (19-62 years), 3 female. Four of five tested had impaired visual and verbal memory preoperatively but not sufficient to contraindicate surgery. Pathology was mesial temporal sclerosis in 3, 1 cavernoma, 1 dysembryoplastic neuroepithelial tumor (DNET) and 1 normal. Postoperatively, four were seizure free 3-12 years off medication and two continued with seizures. There was no unexpected postoperative memory change until incapacitating anterograde amnesia developed 1-24 years after surgery. In five patients, including ours, this followed definite or possible status epilepticus with new mesial temporal sclerosis on the opposite side in the four that were investigated by MRI. One patient developed a glioblastoma in the opposite temporal lobe.Conclusion:Continuing or late recurrence of seizures from the remaining temporal lobe after temporal lobectomy can result in incapacitating amnesia if status epilepticus occurs. Other new lesions on the opposite side to surgery can have the same effect.