bluuebunny/crossref_metadata_2025_split huggingface dataset:
Design of training sequences and channel estimation for amplify-and-forward two-path relaying networks
Authors: Choi Jeong-Min , Han Jae-Shin , Jeon Sungho , Seo Jong-Soo 
Published: July 2014

Abstract
This paper proposes a new channel estimation scheme for two-path relaying networks where two amplify-and-forward (AF) half-duplex relay nodes alternatively transmit the signals received from a source node. The channel estimation and interference cancellation would be mutually conditional in two-path relaying networks. To overcome such a difficulty, we design new training sequences and propose precoding matrices for use at the source and relays. Deriving the Cramer-Rao lower bound (CRLB), it is shown that the proposed estimator is efficient, i.e., the proposed channel estimation scheme achieves the CRLB. The performance of the proposed channel estimation is evaluated through the computer simulations where the validity of the theoretical analysis is also demonstrated.
Safety of repeated transplantations of neurotrophic factors‐secreting human mesenchymal stromal stem cells
Authors: Gothelf Yael , Abramov Natalie , Harel Adrian , Offen Daniel 
Published: July 2014

AbstractBackgroundTherapies based on mesenchymal stem cells (MSC) have been shown to have potential benefit in several clinical studies. We have shown that, using a medium‐based approach, MSC can be induced to secrete elevated levels of neurotropic factors, which have been shown to have protective effects in animal models of neurodegenerative diseases.These cells, designated MSC‐NTF cells (Neurotrophic factor‐secreting MSC, also known as NurOwn™) derived from the patient's own bone marrow, have been recently used for Phase I/II and Phase IIa clinical studies in patients with Amyotrophic Lateral Sclerosis (ALS). In these studies, ALS patients were subjected to a single administration of autologous MSC‐NTF cells. The data from these studies indicate that the single administration of MSC‐NTF cells is safe and well tolerated.In a recently published case report, it was shown that repeated MSC‐NTF injections in an ALS patient treated on a compassionate basis were safe and well tolerated [Muscle Nerve 49:455‐457, 2014].MethodsIn the current study we studied the toxicity and tolerability of three consecutive intramuscular injections (IM) of cryopreserved human MSC‐NTF cells in C57BL/B6 mice to investigate the effect of repeated administration of these cells.ResultsMonitoring of clinical signs and immune reactions showed that repeated injections of the cells did not lead to any serious adverse events. Pathology, histology and blood biochemistry parameters tested were found to be within normal ranges with no sign of tumor formation.ConclusionsBased on these results we conclude that repeated injections of human MSC‐NTF are well tolerated in mice. The results of this study suggest that if the outcomes of additional clinical studies point to the need for repeated treatments, such option can be considered safe.
Raloxifene adjunctive therapy for postmenopausal women suffering from chronic schizophrenia: a randomized double-blind and placebo controlled trial
Authors: Kianimehr Gilda , Fatehi Farzad , Hashempoor Sara , Khodaei-Ardakani Mohammad-Reza , Rezaei Farzin , Nazari Ali , Kashani Ladan , Akhondzadeh Shahin 
Published: July 2014

Abstract

Background
Cumulative evidence from epidemiological, preclinical and clinical studies suggests estrogens may have psychoprotective effects in schizophrenic patients. Selective Estrogen Receptor Modulators could have therapeutic benefits in schizophrenia for both sexes without being hazardous to gynecological tissues or having feminizing effects. Few studies have been conducted regarding the effects of raloxifene on postmenopausal women suffering from schizophrenia. We conducted this placebo-controlled trial to compare the add-on effect of raloxifene to risperidone versus risperidone with placebo.

Methods
This was an 8-week, parallel-group, placebo-controlled trial undertaken at two universities affiliated psychiatric Hospitals in Iran. Forty-six postmenopausal women with the definite diagnosis of schizophrenia were enrolled in the study. Patients received risperidone (6 mg/day in 3 divided doses) combined with either placebo (N = 23) or 120 mg/day of raloxifene (N = 23) for 8 weeks. Patients were assessed by a psychiatrist at baseline and at 2 and 8 weeks after the start of medical therapy. Efficacy was defined as the change from baseline to endpoint in score on Positive and Negative Syndrome Scale (PANSS).

Results
For PANSS scores, the main effect comparing two types of intervention was not significant [F (1, 48) = 1.77, p = 0.18]. For positive subscale scores, there was marginal significant interaction between intervention type and time [F (2, 47) = 2.93, p = 0.06] and there was substantial main effect for time [F (2, 47) = 24.39, p = 0.001] within both groups showing reduction in positive subscale scores across the three time periods. In addition, the main effect comparing two types of intervention was significant [F (1, 48) = 3.78, p = 0.02]. On the other hand, for negative subscale scores, the main effect comparing two types of intervention was not significant [F (1, 48) = 1.43, p = 0.23]. For general subscale scores, the main effect comparing two types of intervention was not significant [F (1, 48) = 0.03, p = 0.86].

Conclusions
According to our findings, raloxifene as an adjunctive treatment to risperidone was only superior in improvement of positive symptoms and it was not effective in treating negative and general psychopathology symptoms.

Trial registration
The trial was registered at the Iranian registry of clinical trials: IRCT201205131556N42
Neuroblastoma presenting like a Wilms’ tumor with thrombus in inferior vena cava and pulmonary metastases: a case series
Authors: Gaetan Genevieve , Ouimet Alain , Lapierre Chantale , Teira Pierre , Sartelet Herve 
Published: July 2014

Abstract
Neuroblastomas and Wilms’ tumors are frequent pediatric solid tumors. The first is frequently detected in the adrenal gland and the second develops in the kidneys. The extension through the vena cava and the lung metastases are frequent in Wilms’ tumors and are rarely seen in neuroblastoma. We present the cases of three children with abdominal tumors with thrombus in the inferior vena cava and pulmonary metastases demonstrating a stage 4 neuroblastoma. The three male patients were between 23 to 48 months old. They presented an abdominal mass, near the superior pole of the kidney. Thrombus of the vena cava was showed on imaging studies in all cases and pulmonary metastases were always found. Catecholamine metabolites were present in the first case and negative in the two others. Two out of three patients had a radical nephrectomy. The pathological analysis always found a poorly differentiated or undifferentiated neuroblastoma without MYCN amplification and confirmed the vein tumoral thrombus in the second case. The evolution of the first two patients was unfavorable and the third is alive. Invasion of the inferior vena cava and pulmonary metastases in children with neuroblastoma is uncommon and can modify the surgical management.
Peroxiredoxin-1 protects estrogen receptor α from oxidative stress-induced suppression and is a protein biomarker of favorable prognosis in breast cancer
Authors: O’Leary Patrick C , Terrile Marta , Bajor Malgorzata , Gaj Pawel , Hennessy Bryan T , Mills Gordon B , Zagozdzon Agnieszka , O’Connor Darran P , Brennan Donal J , Connor Kate , Li Jane , Gonzalez-Angulo Ana Maria , Sun Han-Dong , Pu Jian-Xin , Pontén Fredrik , Uhlén Mathias , Jirström Karin , Nowis Dominika A , Crown John P , Zagozdzon Radoslaw , Gallagher William M 
Published: July 2014

Abstract
Introduction
Peroxiredoxin-1 (PRDX1) is a multifunctional protein, acting as a hydrogen peroxide (H2O2) scavenger, molecular chaperone and immune modulator. Although differential PRDX1 expression has been described in many tumors, the potential role of PRDX1 in breast cancer remains highly ambiguous. Using a comprehensive antibody-based proteomics approach, we interrogated PRDX1 protein as a putative biomarker in estrogen receptor (ER)-positive breast cancer.

Methods
An anti-PRDX1 antibody was validated in breast cancer cell lines using immunoblotting, immunohistochemistry and reverse phase protein array (RPPA) technology. PRDX1 protein expression was evaluated in two independent breast cancer cohorts, represented on a screening RPPA (n = 712) and a validation tissue microarray (n = 498). In vitro assays were performed exploring the functional contribution of PRDX1, with oxidative stress conditions mimicked via treatment with H2O2, peroxynitrite, or adenanthin, a PRDX1/2 inhibitor.

Results
In ER-positive cases, high PRDX1 protein expression is a biomarker of improved prognosis across both cohorts. In the validation cohort, high PRDX1 expression was an independent predictor of improved relapse-free survival (hazard ratio (HR) = 0.62, 95% confidence interval (CI) = 0.40 to 0.96, P = 0.032), breast cancer-specific survival (HR = 0.44, 95% CI = 0.24 to 0.79, P = 0.006) and overall survival (HR = 0.61, 95% CI = 0.44 to 0.85, P = 0.004). RPPA screening of cancer signaling proteins showed that ERα protein was upregulated in PRDX1 high tumors. Exogenous H2O2 treatment decreased ERα protein levels in ER-positive cells. PRDX1 knockdown further sensitized cells to H2O2- and peroxynitrite-mediated effects, whilst PRDX1 overexpression protected against this response. Inhibition of PRDX1/2 antioxidant activity with adenanthin dramatically reduced ERα levels in breast cancer cells.

Conclusions
PRDX1 is shown to be an independent predictor of improved outcomes in ER-positive breast cancer. Through its antioxidant function, PRDX1 may prevent oxidative stress-mediated ERα loss, thereby potentially contributing to maintenance of an ER-positive phenotype in mammary tumors. These results for the first time imply a close connection between biological activity of PRDX1 and regulation of estrogen-mediated signaling in breast cancer.
Starting lithium prophylaxis earlyv.late in bipolar disorder
Authors: Kessing Lars Vedel , Vradi Eleni , Andersen Per Kragh 
Published: July 2014

BackgroundNo study has investigated when preventive treatment with lithium should be initiated in bipolar disorder.AimsTo compare response rates among patients with bipolar disorder starting treatment with lithium earlyv.late.MethodNationwide registers were used to identify all patients with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995–2012 in Denmark (n= 4714). Lithium responders were defined as patients who, following a stabilisation lithium start-up period of 6 months, continued lithium monotherapy without being admitted to hospital. Earlyv.late intervention was defined in two ways: (a) start of lithium following first contact; and (b) start of lithium following a diagnosis of a single manic/mixed episode.ResultsRegardless of the definition used, patients who started lithium early had significantly decreased rates of nonresponse to lithium compared with the rate for patients starting lithium later (adjusted analyses: firstv.later contact:P<0.0001; hazard ratio (HR) = 0.87, 95% CI 0.76–0.91; single manic/mixed episodev.bipolar disorder:P<0.0001; HR = 0.75, 95% CI 0.67–0.84).ConclusionsStarting lithium treatment early following first psychiatric contact or a single manic/mixed episode is associated with increased probability of lithium response.
Sponsored Search Marketing: Dynamic Pricing and Advertising for an Online Retailer
Authors: Ye Shengqi , Aydin Goker , Hu Shanshan 
Published: July 2014

Consider a retailer using sponsored search marketing together with dynamic pricing. The retailer's bid on a search keyword affects the retailer's rank among the search results. The higher the rank, the higher the customer traffic and the customers' willingness to pay will be. Thus, the question arises: When a retailer bids higher to attract more customers, should the accompanying price also decrease (to strengthen the bid's effect on demand) or increase (to take advantage of higher willingness to pay)? We find that the answer depends on how fast the retailer increases its bid. In particular, as the end of the season approaches, the optimal bid exhibits smooth increases followed by big jumps. The optimal price increases only when the optimal bid increases sharply, including the instances where the bid jumps up. Such big jumps arise, for example, when the customer traffic is an S-shaped function of the retailer's bid. This paper was accepted by Serguei Netessine, operations management.
Impossible family portraits: Users, new media technologies and the writing of amateur media history
Authors: Aasman Susan 
Published: July 2014

Abstract
With the shift from analog to digital the field of amateur media widened as the technologies of image production, distribution and screening altered considerably. The many transformations of home moviemaking chart it as something that used to need a film camera and film, a detailed development process, a projector and a darkened room, into something that today can be done with a mobile phone. New terms have come along to describe these diverse amateur practices like home video, video diaries or user-generated content. It is time to re-evaluate these practices that so far have been marginal to media history. This article aims to open the space for new perspectives on the history of amateur media by tracing the changing relations between new technologies and different uses of amateur film and video. Charting why and how people choose to use specific technologies at particular moments and how economic, social and cultural factors influence these choices could help us to understand how some technologies became embedded in our lives and others not. The suggestion put forward in this article is that we can only gain more insight if we are less medium specific on the one hand and more case specific on the other.
Of national ‘Significance’: Politicizing the home movies of the US National Film Registry
Authors: Mauro Daniel 
Published: July 2014

Abstract
Amongst archived collections of motion picture materials, home movies occupy an enigmatic position. The National Film Registry of the United States is a high-profile collection that includes home movies and, in the act of collecting, radically reframes the perceived cultural value and politics of the films. Established by the National Film Preservation Act of 1988, the National Film Registry aims to collect films that are ‘culturally, historically or aesthetically significant’ and preserve them in service of maintaining a US film heritage. Yet do the home movies selected represent a ‘significantly’ national symbol? This article examines the private and public trajectories of the home movies selected for the Registry, arguing that the films are selected with the primary goal of mobilizing particular political narratives according to the ideologies and biases of the National Film Preservation Board and Librarian of Congress. Furthermore, this article examines the ramifications of such political selections on the shaping of a US national film heritage. These issues are discussed through three key analyses: (1) an examination of the politics of collecting and canonization with respect to the goals and operations of the Registry as evidenced through publications and accounts of key figures involved in the selection of the home movies; (2) tracings of the trajectories of the individual home movies as they developed from private films into pieces of public history; and (3) a consideration of how the selection of these home movies more broadly affects the construction and consumption of a US national film heritage.
Ayisha Abraham’s Straight 8
Authors: Gopalan Lalitha 
Published: July 2014

Abstract
At stake in this article is the very act of writing on expanded cinema. Provoked by Gene Youngblood’s canonical offering of fluid state of media as it moved out of the exclusive domain of celluloid to a range of practices that include video, computer and so on, I look at practices in India that exhibit a similar movement out of the movie theatre. It is one matter to identify the practice of expanded cinema but it is quite a different matter, perhaps more challenging, to translate those practices intro a form that is attentive to the works. This article draws on Ayisha Abraham’s Straight 8 (2005). How to approach a film, when to leave a video, and how to meander through a gallery space are some of the pathways adopted in this article, modes of exploration that return to the act of writing.
Mentoring Experiences of Latina Graduate Students
Authors: García Irán O. , Henderson Sheila J. 
Published: July 2014

Abstract
In order to contribute to knowledge on the Latina graduate students’ experiences and the role of mentoring relationships in their pursuit of higher education, the purpose of this qualitative study was to interview Latina doctoral students about their lived experience. Four Latina graduate students at a graduate university in San Francisco, California were recruited by way of student email lists, flyers, and social networks such as Facebook, LinkedIn, Hi5, and word of mouth. Participants took part in a face-to-face interview guided by semi-structured questions. Within the same cultural and cross-cultural mentoring relationship experiences described, a sequential analysis of the interview transcripts revealed the following themes consistent with the Kram model of mentoring: (a) conceptualizations of a “good mentor,” (b) how mentoring influenced their pursuit of graduate studies, and (c) the impact of mentoring on their self-confidence and self-esteem. While many studies exist on mentoring students, there is relatively little research on the mentoring experiences of Latina graduate students. It is hoped that this small study will motivate much needed further research in the mentoring needs of the Latina/o community. One possible issue revealed in this study was the absence of within culture or cross-cultural mentoring for Latina graduate students.
Deciphering an interplay of proteins associated with amyloid β 1-42 peptide and molecular mechanisms of Alzheimer’s disease
Authors: Hernández-Zimbrón Luis Fernando , Rivas-Arancibia Selva 
Published: July 2014

AbstractExtracellular and intracellular accumulation of amyloid beta 1-42 peptide in different states of aggregation has been involved in the development and progression of Alzheimer’s disease. However, the precise mechanisms involved in amyloid beta peptide neurotoxicity have not been fully understood. There exists a wide variety of studies demonstrating the binding of amyloid beta peptide to a great variety of macromolecules and that such associations affect the cellular functions. This type of association involves proteins and receptors anchored to the plasma membrane of neurons or immune cells of the central nervous system as well as intracellular proteins that can alter intracellular transport, activate signaling pathways or affect proper mitochondrial function. In this review, we present some examples of such associations and the role played by these interactions, which are generally involved in the pathological progression of Alzheimer’s disease.
Treatment of Complex Intracranial Aneurysms Using Flow-Diverting Silk® Stents An Analysis of 32 Consecutive Patients
Authors: Buyukkaya Ramazan , Kocaeli Hasan , Yildirim Nalan , Cebeci Hakan , Erdogan Cüneyt , Hakyemez Bahattin 
Published: July 2014

This study describes the peri-procedural and late complications and angiographic follow-up results of 32 patients with 34 complex aneurysms treated with flow diverter Silk stents in a single centre. In this retrospective study, 40 Silk stents (SS) were implanted in 34 complex intracranial aneurysms in 32 patients. In our series, 20 (58.8%) carotid-ophthalmic internal carotid artery (ICA), six (17.6%) cavernous ICA, two (5.9%) supraclinoid ICA, two (5.9%) petrosal ICA (the same patient- bilateral) and four (11.8%) posterior circulation aneurysms were treated. One of the posterior circulation lesions was a fenestrated-type aneurysm. Twenty wide-necked, saccular; eight neck remnant; four fusiform and two blister-like aneurysms were included in our series. SS were successfully implanted in all patients (100%). Misdeployment occurred in 17.6% of patients. In two of these patients adequate stent openness was achieved via Hyperglide balloon dilatation. Coil embolization in addition to SS placement was utilized in four aneurysms. One patient (3%) experienced transient morbidity due to a thromboembolic event and there was one mortality (3%) due to remote intraparenchymal haemorrhage. Complete occlusion of 27/33 (81.8%) and 29/33 (87.9%) aneurysms was achieved six and 12 months after the procedure, respectively. In-stent intimal hyperplasia was detected in 6.1% patients. Flow-diverter Silk stent implantation is an effective method of treating complex aneurysms with acceptable mortality and morbidity rates. Complete occlusion is achieved in most of the complex aneurysms.
Genetic Basis for Saccharomyces cerevisiae Biofilm in Liquid Medium
Authors: Andersen Kaj Scherz , Bojsen Rasmus , Sørensen Laura Gro Rejkjær , Nielsen Martin Weiss , Lisby Michael , Folkesson Anders , Regenberg Birgitte 
Published: July 2014

Abstract
Biofilm-forming microorganisms switch between two forms: free-living planktonic and sessile multicellular. Sessile communities of yeast biofilms in liquid medium provide a primitive example of multicellularity and are clinically important because biofilms tend to have other growth characteristics than free-living cells. We investigated the genetic basis for yeast, Saccharomyces cerevisiae, biofilm on solid surfaces in liquid medium by screening a comprehensive deletion mutant collection in the Σ1278b background and found 71 genes that were essential for biofilm development. Quantitative northern blots further revealed that AIM1, ASG1, AVT1, DRN1, ELP4, FLO8, FMP10, HMT1, KAR5, MIT1, MRPL32, MSS11, NCP1, NPR1, PEP5, PEX25, RIM8, RIM101, RGT1, SNF8, SPC2, STB6, STP22, TEC1, VID24, VPS20, VTC3, YBL029W, YBL029C-A, YFL054C, YGR161W-C, YIL014C-A, YIR024C, YKL151C, YNL200C, YOR034C-A, and YOR223W controlled biofilm through FLO11 induction. Almost all deletion mutants that were unable to form biofilms in liquid medium also lost the ability to form surface-spreading biofilm colonies (mats) on agar and 69% also lost the ability to grow invasively. The protein kinase A isoform Tpk3p functioned specifically in biofilm and mat formation. In a tpk3 mutant, transcription of FLO11 was induced three-fold compared with wild-type, but biofilm development and cell–cell adhesion was absent, suggesting that Tpk3p regulates FLO11 positive posttranscriptionally and negative transcriptionally.
The study provides a resource of biofilm-influencing genes for additional research on biofilm development and suggests that the regulation of FLO11 is more complex than previously anticipated.