bluuebunny/crossref_metadata_2025_split huggingface dataset:
Changes in expression of calbindin 28 kDa in the small intestine of red kidney bean (Phaseolus vulgaris) lectin-treated suckling piglets
Authors: Zacharko-Siembida A. , Valverde Piedra J.L. , Arciszewski M.B. 
Published: August 2013

AbstractCalbindin (CB) is a calcium binding protein playing a role in calcium uptake and anti-apoptotic cellular protection. The expression of CB was immunohistochemically studied in the small intestine of normal and red bean kidney lectin-treated suckling piglets. In the duodenum and jejunum (but not ileum) of lectin-treated animals overexpression of CB was noted in chromogranin A-immunoreactive (CgA-IR) neuroendocrine (NE) cells. In both control and experimental group a small population of CB-IR NE cells exhibited the presence of somatostatin (but not serotonin, histamine or CRF). After the lectin treatment, an increased (however not statistically significant) immunoreactivity to CB was found in a small subpopulation of neurons of outer submucous (but not inner submucous and myenteric) plexus. It is suggested that there is a functional interaction between lectin administration and CB-expression in the porcine small intestine. Future studies will be needed to clarify this processes.
Cytoprotective effect of silybin against lasalocid-induced toxicity in HepG2 cells
Authors: Radko L. , Cybulski W. , Rzeski W. 
Published: August 2013

AbstractLasalocid is an ionophore coccidiostatic agent frequently used in poultry. Its extensive use causes the formation of residues in edible tissues and eggs which may pose a risk to consumers. Silybin is the main compound extracted from the herb milk thistle Silybum marianum and its hepatoprotective effect has been reported in literature.The aim of the study was to compare lasalocid and silybin cytotoxic effects followed by their combined use in HepG2 cell line. A cytoprotective effect resulting from the interaction of both pharmacologically active substances was measured.In this study, an MTT test, coomassie brillant blue binding test, and LDH release test determined the effective concentration (EC50) of the compounds. The isobolograms and combination index were used to assess the nature of interaction.The lowest EC50-value for lasalocid was established via the MTT test. This study revealed a lack of silybin cytotoxic effect on the cells. Co-actions of the two drugs led to a significant decrease of lasalocid cytotoxicity. The isobolograms and combination index showed a remarkable antagonistic effect in the course of silybin and lasalocid interaction.The results indicate that silybin revealed a cytoprotective effect when incubated with lasalocid since its cytotoxic impact on HepG2 cells has been significantly diminished.
Plasmid profile analysis and evaluation of antibiotic susceptibility of Staphylococcus aureus strains isolated from table chicken eggs
Authors: Pyzik E. , Marek A. 
Published: August 2013

AbstractThe aim of this study was to isolate and characterize Staphylococcus aureus bacteria present on the shell surfaces and in the contents of chicken eggs, taking into account their phenotypic properties, antibiotic susceptibility patterns, and the presence of plasmid DNA. The study included 90 table chicken eggs from laying farms situated in the vicinity of Lublin. A total of 105 bacterial strains identified as Staphylococcus were isolated from the material, of which 18 (17.14%) were of the species Staphylococcus aureus. All 18 S. aureus strains were found to be resistant to at least one of the antibiotics tested, while some (55.55%) showed resistance to five or more of the 17 therapeutic agents. The greatest number of strains showed resistance to erythromycin (66.66%), tetracycline (66.66%), oxytetracycline (61.11%), penicillin G (50%), and amoxicillin (44.44%). The plasmid profile analysis of the S. aureus strains made it possible to evaluate the dependence between antibiotic susceptibility and the presence of plasmids in particular isolates. The results showed that plasmids in various quantities and of varying molecular weights were isolated from 17 of the strains. Most often isolated were small plasmids, of 5.6 kb - from 11 of the S. aureus strains (61.11%), 2.5 kb - from 9 strains (50%), 4.1 kb - from 8 (44.44%), and 4.6 kb - from 7 (38.88%) of the strains.
The effects of experimental administration of low doses of zearalenone on the histology of ovaries in pre-pubertal bitches
Authors: Gajęcka M. 
Published: August 2013

AbstractThe experiment involved 30 clinically healthy Beagle bitches aged approximately 70 days with an initial body weight of approximately 8 kg. The animals were randomly divided into two experimental groups (EI and EII) and a control group of 10 animals each. Group EI was administered 50 μg of body weight zearalenone/kg per os for 42 days, group EII received 75 μg of body weight zearalenone/kg per os for 42 days, and the control group was administered placebo per os for 42 days. The bitches were ovariectomized at the end of the treatment period for anatomopathological examination. At the same time, peripheral blood samples were collected for endocrinological analyses (17β-estradiol and progesterone). Administartion of zearalenone particularly higher doses, resulted in the hyperestrogenism degeneration and atrophy of ovarian cells and tissues with accompanying edema and blood extravasation, leading to increased 17β-estradiol concentrations and an insignificant decrease in progesterone levels.
The effect of different dietary levels of vitamin E and selenium on antioxidant status and immunological markers in serum of laying hens
Authors: Zduńczyk Z. , Drażbo A. , Jankowski J. , Juśkiewicz J. , Czech A. , Antoszkiewicz Z. 
Published: August 2013

Abstract
The effect of different dietary levels of selenium (Se) and vitamin E on egg production, the antioxidant status and the immune system response of hens was investigated in the current study. A total of 32 Lohman Brown hens were divided into four groups and were fed diets with 5% of soybean oil and two levels of Se (0.15 and 0.30 mg/kg) and vitamin E (30 and 60 mg/kg). During 10 weeks of experimental feeding, the body weights of hens and egg production were similar in all dietary treatments, but a higher Se content of diets contributed to a significant increase in egg weight. A higher vitamin E level significantly increased α-tocopherol concentrations (2.71 vs. 2.05 μg/mL, p = 0.001), superoxide dismutase (SOD) activity (43.3 vs. 39.9 U/mL, p = 0.049) and the ferric reducing ability of serum (FRAP) (123.0 vs. 105.7 μmol/L, p = 0.029). A higher Se content increased the concentrations of ascorbic acid (0.309 vs. 0.073 μg/L, p = 0.001), retinol (1.48 vs. 1.15 μg/mL, p = 0.001) and α-tocopherol (2.86 vs. 1.90 μg/mL, p = 0.001), the activity levels of catalase (3.40 vs. 2.98 U/L, p = 0.010) and SOD (43.4 vs. 30.8 U/mL, p = 0.040) as well as the total antioxidant status (TAS) of serum (0.38 vs. 0.28 mmol/L, p = 0.026). There were no significant differences in the concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) between treatments, while a higher vitamin E content of diets increased serum immunoglobulin A (IgA) concentrations (370.6 vs. 321.3 μg/mL, p = 0.026). Higher dietary levels of vitamin E and Se increased the serum concentrations of retinol (1.66 vs. 2.20 μg/mL, p = 0.013) and α-tocopherol (3.33 vs. 1.71, p = 0.014), but they had no effect on the other physiological parameters. It is recommended that the levels of both supplements, Se and vitamin E, be increased in laying hen diets as they have a beneficial effect on the serum concentrations of retinol and α -tocopherol
Influence of mutation in cj0183 and cj0588 genes for colonization abilities of Campylobacter jejuni in Caco-2 cells using confocal laser scanning microscope
Authors: Sałamaszyńska-Guz A. , Godlewski M.M. , Klimuszko D. 
Published: August 2013

AbstractThe cj0183 and cj0588 genes identified in the Campylobacter jejuni NCTC 11168 genome encode proteins with homology to virulence factors found in other bacteria. Previous studies showed that single mutation in the cj0183 gene does not affect adhesion of C. jejuni to the Caco-2 cell line whereas protein encoded by cj0588 is involved in adherence to the Caco-2 cells. In the presented study differences in invasion index were observed between mutants in both genes and single mutation of cj0588 in 81116 and 81-176 C. jejuni strains. This fact indicates that Cj0183 protein might play some role in invasion of bacteria into host cells.
Redox signals as a language of interorganellar communication in plant cells
Authors: Kopczewski Tomasz , Kuźniak Elżbieta 
Published: August 2013

AbstractPlants are redox systems and redox-active compounds control and regulate all aspects of their life. Recent studies have shown that changes in reactive oxygen species (ROS) concentration mediated by enzymatic and non-enzymatic antioxidants are transferred into redox signals used by plants to activate various physiological responses. An overview of the main antioxidants and redox signaling in plant cells is presented. In this review, the biological effects of ROS and related redox signals are discussed in the context of acclimation to changing environmental conditions. Special attention is paid to the role of thiol/disulfide exchange via thioredoxins (Trxs), glutaredoxins (Grxs) and peroxiredoxins (Prxs) in the redox regulatory network. In plants, chloroplasts and mitochondria occupying a chloroplasts and mitochondria play key roles in cellular metabolism as well as in redox regulation and signaling. The integrated redox functions of these organelles are discussed with emphasis on the importance of the chloroplast and mitochondrion to the nucleus retrograde signaling in acclimatory and stress response.
On the Uniqueness and Continuous Dependence in the Linear Theory of Thermo-Microstretch Elasticity Backward in Time
Authors: Bulgariu Emilian 
Published: August 2013

Abstract
We study the uniqueness and the continuous dependence problems for the thermo-microstretch elastic processes backward in time. The data are given for the final time t = 0 and we want to study the solution at the previous moments. We transform the problem in a boundary-initial value problem by an appropriate change of variables. The uniqueness theorems presented in this article extend in a particular case the uniqueness theorem of Passarella and Tibullo (2010) and we also discuss a different class of problems than the one considered by them. We find some estimates that prove the continuous dependence of solution with respect to the final data.
Generalized Cofinitely δ-Semiperfect Modules
Authors: Yüzbaşi Figen , Eren Şenol 
Published: August 2013

Abstract
Let R be a ring and M be a left R-module. M is called a cofinitely generalized (weak) δ-supplemented module or briey a δ-CGS-module (δ-CGWS-module) if every cofinite submodule of M has a generalized (weak) δ-supplement in M. In this paper, we give various properties of these modules. It is shown that (1) The class of cofinitely generalized (weak) δ-supplemented modules are closed under taking homomorphic images, arbitrary sums, generalized δ-covers and closed under extensions. (2) M is a generalized cofinitely δ-semiperfect module if and only if M is a cofinitely generalized δ-supplemented by generalized δ-supplements which have generalized projective δ-covers.
Northern Ways to Think About Music: Glenn Gould's Idea of North as an Aesthetic Category
Authors: Mantere Markus 
Published: August 2013

This article discusses the role played by the concept of "North" in Glenn Gould's musical thought. In Gould's writings and interviews, the meaning of the "North" is twofold:( 1) The concept refers to musical phenomena and qualities (counterpoint, non-virtuosity, sonic austerity) which were important for Gould's value judgments of music; (2) Gould used the concept as a metaphor, enabling him to bring together the ideas of isolation, the use of technology to creatively "opt-out," and the notion of non-competition into a coherent aesthetic and ethical perspective. Through a study of Gould's written documents, the concept of "North" will be examined to establish a hermeneutic framework within which to better appreciate and evaluate Gould's musicianship.
La musique de chambre de Darius Milhaud
Authors: Duchesneau Michel 
Published: August 2013

Darius Milhaud, musicien prolifique, a composé plus de 600 œuvres et nombre d’entre elles sont destinées à la musique de chambre. Ce corpus constitue, aux yeux mêmes du compositeur, une des parts principales dans l’ensemble de sa création. Cette étude tente de répondre à trois questions : (1) Quels liens peut-on établir entre le contexte et la création dans la musique de Milhaud? (2) La qualité spécifique de ces partitions peut-elle éclairer une vision globale du corpus? (3) En quoi le langage musical de Milhaud est-il propre à intégrer les éléments d’influences diverses tels que le folklore sud-américain ou le jazz? Ce corpus témoigne du fait que les relations entre les intentions du compositeur et le milieu artistique sont fondamentales. D’autre part, les principales qualités de la musique de chambre de Milhaud résident dans sa diversité plutôt que dans son caractère novateur. Milhaud exerçait un métier, celui de compositeur. Inspiré par la vie quotidienne, il revêt le manteau de l’artiste-artisan plus souvent qu’autrement.
Le hasard et la technologie chez John Cage : subsistance de la modernité
Authors: Rivest Johanne 
Published: August 2013

Bien que l’on range communément John Cage dans le camp postmoderne, l’auteure entend démontrer que plusieurs traits de la modernité se retrouvent dans sa pratique artistique. Deux aspects principaux en ont été retenus, soit le hasard et la technologie, lesquels se rapportent à la modernité par la manière dont Cage les utilise. D’autres traits de la modernité servent également de points d’ancrage à cette thèse — comme la distanciation objective et l’autonomie de l’œuvre, la critique du convenu en art ou du « musical » en musique, l’idée de progrès ou de changement — à quoi s’opposent certains éléments de l’avant-garde à laquelle Cage se rattache également, paradoxalement.
La Frauenseele dans tous ses états : les Altenberg lieder, opus 4, nos II et III de Berg comme réponse à la Frauenfrage viennoise
Authors: Pedneault Deslauriers Julie 
Published: August 2013

Cet article effectue une analyse herméneutique desAltenberg Liederopus 4 nos2 et 3 d’Alban Berg. Les lieder sont analysés à la lumière de l’esthétique de la persona feminine développée par le controversé poète (et ami de Berg) Peter Altenberg, et qui prendrait le nom de «Frauenkult ».L’auteure démontre ici comment le traitement motivique, les stratégies de conduite des voix et leur relation avec les poèmes sélectionnés par Berg font résonner deux des conceptions principales duFrauenkult : la valorisation d’une sexualité féminine plus autonome et la transcendance de l’âme féminine.
Narrative Theory and Music; Or, the Tale of Kundry's Tale
Authors: McClatchie Stephen 
Published: August 2013

In recent years, narrative theory has been an influential model for many writers on music. Things in musical syntax like repetitions, expectations, and resolutions make it tempting to speak of music as narrative, as an emplotment of events, yet such a model in fact involves more narrativization than narrative. It is perhaps more fruitful to focus upon the musical side of unambiguously narrative moments.
In this paper, I want to try to integrate recent approaches to musical narration by suggesting that narrative in music is a performance which functions according to the logic of the supplement. My approach will be two-fold: first, I want to justify restricting the enquiry to pre-existing narratives set to music by considering the limitations of the emplotment model; second, I shall use Kundry's Act II narrative in Wagner's Parsifal as a magnet to attract a number of narrative approaches: some will stick and some will not.
Du « maghanage » : la re(-)présentation de l’Histoire dans Le marquis qui perdit de Réjean Ducharme
Authors: Jaubert Claire 
Published: August 2013

Le marquis qui perdit, texte négligé par la critique et la scène québécoises, constitue une oeuvre dramatique intéressante dès lors qu’on aborde la question de l’« américanité » du Québec. Par cette réécriture de la fin du Canada français, Réjean Ducharme propose une oeuvre déroutante, jouant de la parodie autant que de l’autoparodie grinçante, et une vision outrancière de l’histoire de son pays.
Occupy, indignados, et le Printemps Érable : vers un agenda de recherche
Authors: Weinstock Daniel 
Published: August 2013

Les mobilisations populaires dont ont été témoins
plusieurs sociétés occidentales soulèvent de
nombreuses questions de philosophie politique et juridique que les
chercheurs de ces disciplines devront s’approprier s’ils
veulent contribuer de manière utile au débat social que
nous imposent les protagonistes du mouvement Occupy, les Indignados,
ou encore les citoyens qui sont descendus dans la rue au Québec
au moment du Printemps Érable. Les questions les plus urgentes
nous semblent être les suivantes : les manifestations et
protestations publiques font-elles une entorse à la
démocratie en ne passant pas par les institutions formelles, ou
bien devraient-elles, à certaines conditions, être
perçues comme faisant partie de la vie démocratique?
Deuxièmement, quelle est l’extension de la notion de
« grève »? S’agit-il d’un
non-sens pour une association étudiante de prétendre
qu’elle peut, au même titre qu’un syndicat de
travailleurs, se prévaloir de cet outil de pression?
Troisièmement, quelles sont les conditions qui rendent
légitime dans le contexte d’une démocratie
libérale le recours à la désobéissance
civile? Enfin, la conception de la propriété
privée, centrale aux sociétés occidentales
modernes, exclut-elle que même la propriété
privée puisse avoir des fonctions sociales, en vertu desquelles
cette institution tirerait peut-être même sa justification?
Dunsmuir’s Flaws Exposed: Recent Decisions on Standard of Review
Authors: Daly Paul 
Published: August 2013

In Dunsmuir v. New Brunswick, the Supreme Court of Canada
attempted to clarify and simplify Canadian judicial review doctrine. I
argue that the Court got it badly wrong, as evidenced by four of its
recent decisions.
The cases demonstrate that the new categorical approach is unworkable.
A reviewing court cannot apply the categorical approach without
reference to something like the much-maligned “pragmatic and
functional” analysis factors. The categories regularly come into
conflict, in that decisions could perfectly reasonably be assigned to
more than one category. When conflict occurs, it must be resolved by
reference to some factors external to the categorical approach.
The new, single standard of reasonableness is similarly unworkable
without reference to external factors. Different types of decision
attract different degrees of deference, on the basis of factors that
are external to the elegant elucidation of reasonableness offered in Dunsmuir.
Clarification and simplicity have thus not been achieved.
A Miniaturized Multipurpose Platform for Rapid, Label‐Free, and Simultaneous Separation, Patterning, and In Vitro Culture of Primary and Rare Cells
Authors: Didar Tohid Fatanat , Bowey Kristen , Almazan Guillermina , Tabrizian Maryam 
Published: August 2013

AbstractGiven that current cell isolation techniques are expensive, time consuming, yield low isolation purities, and/or alter target cell properties, a versatile, cost effective, and easy‐to‐operate microchip with the capability to simultaneously separate, capture, pattern, and culture rare and primary cells in vitro is developed. The platform is based on target cell adhesion onto the micro‐fabricated interfaces produced by microcontact printing of cell‐specific antibodies. Results show over 95% separation efficiency in less than 10 min for the separation of oligodendrocyte progenitor cells (OPCs) and cardiomyocytes from rat brain and heart mixtures, respectively. Target cell attachment and single cell spreading can be precisely controlled on the basis of the designed patterns. Both cell types can maintain their biofunctionality. Indeed, isolated OPCs can proliferate and differentiate into mature oligodendrocytes, while isolated cardiomyocytes retain their contractile properties on the separation platform. Successful separation of two dissimilar cell types present in varying concentrations in their respective cell mixtures and the demonstration of their integrity after separation open new avenues for time and cost‐effective sorting of various cell types using the developed miniaturized platform.
Carbon‐Nanotube‐Modified Electrodes for Highly Efficient Acute Neural Recording
Authors: Shin Jung Hwal , Kim Guk Bae , Lee Eun Joo , An Taechang , Shin Kumjae , Lee Seung Eun , Choi WooSeok , Lee Sukchan , Latchoumane Charles , Shin Hee‐Sup , Lim Geunbae 
Published: August 2013

AbstractMicroelectrodes are widely used for monitoring neural activities in various neurobiological studies. The size of the neural electrode is an important factor in determining the signal‐to‐noise ratio (SNR) of recorded neural signals and, thereby, the recording sensitivity. Here, it is demonstrated that commercial tungsten microelectrodes can be modified with carbon nanotubes (CNTs), resulting in a highly sensitive recording ability. The impedance with the respect to surface area of the CNT‐modified electrodes (CNEs) is much less than that of tungsten microelectrodes because of their large electrochemical surface area (ESA). In addition, the noise level of neural signals recorded by CNEs is significantly less. Thus, the SNR is greater than that obtained using tungsten microelectrodes. Importantly, when applied in a mouse brain in vivo, the CNEs can detect action potentials five times more efficiently than tungsten microelectrodes. This technique provides a significant advance in the recording of neural signals, especially in brain regions with sparse neuronal densities.
Survival of trisomy 18 (Edwards syndrome) and trisomy 13 (Patau Syndrome) in England and Wales: 2004–2011
Authors: Wu Jianhua , Springett Anna , Morris Joan K. 
Published: August 2013

AbstractThe aim of this study is to determine the survival of live births with trisomy 18 and trisomy 13 and their variants. Information on live births with trisomy 18 or trisomy 13 recorded in the National Down Syndrome Cytogenetic Register (NDSCR) was linked by the NHS Information Centre to obtain information about survival. Survival was known for 326 (88%) of live births with trisomy 18 and 142 (82%) of live births with trisomy 13 born in England and Wales between 2004 and 2011. The median survival time for live births with full trisomy 18 was 14 days and with full trisomy 13 was 10 days, the 3‐month survival was 20% and 18%, respectively, and the 1‐year survival for both syndromes was 8%. The 1‐year survival for live births with trisomy 18 mosaicism (n = 17) was 70%, for those with trisomy 13 mosaicism (n = 5) was 80% and for those with partial trisomy 13 (Robertsonian translocations) (n = 17) was 29%. This study is based on the largest data set on survival for live births with trisomy 18 and trisomy 13. Although median survival for these children is 2 weeks or less, about one in five survive for 3 months or more and about 1 in 12 survive for 1 year or more. We suggest that these survival rates are used in counselling as well as the median survival time. © 2013 Wiley Periodicals, Inc.