bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell therapy attempted as a novel approach for chronic traumatic brain injury – a pilot study
Authors: Sharma Alok , Sane Hemangi , Kulkarni Pooja , Yadav Jayanti , Gokulchandran Nandini , Biju Hema , Badhe Prerna 
Published: January 2015

Abstract
Traumatic brain injury is an injury to the brain parenchyma resulting from external factors such as vehicular accidents, falls, or sports injuries. Its outcome involves primary insult followed by a cascade of secondary insult, resulting in diffuse axonal injury further causing white matter damage. Surgical intervention targets the primary damage, whereas only few treatment alternatives are available to treat the secondary damage. Cellular therapy could be one of the prospective therapeutic options, as it has the potential to arrest the degeneration and promote regeneration of new cells in the brain. We conducted a pilot study on 14 cases who were administered with autologous bone marrow mononuclear cells, intrathecally. The follow up was done at 1 week, 3 months and 6 months after the intervention. The Functional Independence Measure scale, the SF-8 Health Survey Scoring and the disability rating scale were used as outcome measures. These scales showed a positive shift in scores at the end of 6 months. Improvements were observed in various symptoms, along with activities of daily living. Improvement in PET CT scan performed before and 6 months after the intervention in 3 patients corresponded to the clinical and functional improvements observed in these patients. The results of this study suggest that cell therapy may promote functional recovery leading to an improved quality of life in chronic TBI. Although the results are positive, the improvements after cell therapy are not optimal. Hence, additional multicenter, controlled studies are required to establish cell therapy as a standard therapeutic approach.
OpenCalphad - a free thermodynamic software
Authors: Sundman Bo , Kattner Ursula R , Palumbo Mauro , Fries Suzana G 
Published: January 2015

AbstractThermodynamic data are essential for the understanding, developing, and processing of materials. The CALPHAD (Calculation of Phase Diagrams) technique has made it possible to calculate properties of multicomponent systems using databases of thermodynamic descriptions with models that were assessed from experimental data. A large variety of data, such as phase diagram and solubility data, including consistent thermodynamic values of chemical potentials, enthalpies, entropies, thermal expansions, heats of transformations, and heat capacities, can be obtained from these databases. CALPHAD calculations can be carried out as stand-alone calculations or can be carried out coupled with simulation codes using the result from these calculations as input. A number of CALPHAD software are available for the calculation of properties of multicomponent systems, and the majority are commercial products. The OpenCalphad (OC) software, discussed here, has a simple programming interface to facilitate such integration in application software. This is important for coupling validated thermodynamic as well as kinetic data in such simulations for obtaining realistic results. At present, no other high quality open source software is available for calculations of multicomponent systems using CALPHAD-type models, and it is the goal of the OC source code to fill this gap. The OC software is distributed under a GNU license. The availability of the source code can greatly benefit scientists in academia as well as in industry in the development of new models and assessment of model parameters from both experimental data and data from first principles calculations.
Microarray-based characterization of differential gene expression during vocal fold wound healing in rats
Authors: Welham Nathan V. , Ling Changying , Dawson John A. , Kendziorski Christina , Thibeault Susan L. , Yamashita Masaru 
Published: January 2015

Abstract
The vocal fold (VF) mucosa confers elegant biomechanical function for voice production but is susceptible to scar formation following injury. Current understanding of VF wound healing is hindered by a paucity of data and is therefore often generalized from research conducted in skin and other mucosal systems. Here, using a previously validated rat injury model, expression microarray technology and an empirical Bayes analysis approach, we generated a VF-specific transcriptome dataset to better capture the system-level complexity of wound healing in this specialized tissue. We measured differential gene expression at 3, 14 and 60 days post-injury compared to experimentally naïve controls, pursued functional enrichment analyses to refine and add greater biological definition to the previously proposed temporal phases of VF wound healing, and validated the expression and localization of a subset of previously unidentified repair- and regeneration-related genes at the protein level. Our microarray dataset is a resource for the wider research community and has the potential to stimulate new hypotheses and avenues of investigation, improve biological and mechanistic insight, and accelerate the identification of novel therapeutic targets.
Fabrication of Mesostructured Silica Materials through Co-Structure-Directing Route
Authors: Huang Zhehao , Che Shunai 
Published: January 2015

Abstract
This account describes our recent advances on the fabrication of mesoporous/mesostructured silica materials through the co-structure-directing route. This route establishes critical interactions between the head groups of templates and co-structure-directing agent (CSDA) to form highly ordered mesostructures and well-defined morphologies. Three particular approaches are described based on the different kinds of templates: anionic surfactants, cationic surfactants, and biomolecules (DNA and peptides). Notably, because of the pairing effect between templates and CSDA, the functional groups can be arranged regularly in the surface of the mesopores. Moreover, the applications and future perspective of mesoporous materials synthesized through co-structure-directing route are briefly described.
Subcutaneous Panniculitis-Like T-Cell Lymphoma With Bone Marrow Involvement
Authors: Brown Noah A. , Ross Charles W. , Gudjonsson Johann E. , Wale Daniel , Pawarode Attaphol , Maillard Ivan , Hristov Alexandra C. 
Published: January 2015

Abstract

Objectives:
To describe a rare case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with morphologic and immunophenotypic evidence of bone marrow involvement.

Methods:
Biopsy specimens of skin and subcutis and bone marrow were examined using H&E-stained sections. Immunohistochemical studies for CD2, CD3, CD4, CD5, CD7, CD8, CD20, CD30, CD56, and granzyme B were reviewed. In addition, T-cell receptor γ gene rearrangement studies were performed.

Results:
A bone marrow core biopsy demonstrated several lymphohistiocytic aggregates containing atypical, cytotoxic T cells that rimmed adipocytes and were associated with karyorrhexis. These T cells were morphologically and immunophenotypically identical to a concurrent SPTCL, expressing CD2, CD3, CD7, CD8, and granzyme B but with diminished CD5 expression.

Conclusions:
SPTCL may rarely involve the bone marrow. Bone marrow infiltrates show a similar morphologic and immunophenotypic appearance to those in the subcutaneous fibroadipose tissue, including rimming of adipocytes by neoplastic lymphocytes.
Non-thermal plasma treatment induces MAPK signaling in human monocytes
Authors: Bundscherer Lena , Nagel Stefanie , Hasse Sybille , Tresp Helena , Wende Kristian , Walther Reinhard , Reuter Stephan , Weltmann Klaus-Dieter , Masur Kai , Lindequist Ulrike 
Published: January 2015

Abstract
The application of non-thermal atmospheric
pressure plasma raises a hope for the new wound healing
strategies. Next to its antibacterial effect it is known
to stimulate skin cells. However, monocytes are also
needed for the complex process of a wound healing.
This study investigates the impact of plasma on the
intracellular signaling events in the primary human
monocytes. The proliferative MEK-ERK (MAPK/ERK
kinase-extracellular signal-regulated kinase) pathway was
activated by short plasma treatment times. In contrast, an
induction of the apoptotic JNK (c-Jun N-terminal kinase)
cascade as well as activation of caspase 3 were observed
after long plasma exposure. These findings indicate that
monocytes can be differentially stimulated by plasma
treatment and may contribute to the proper wound recovery.
Interlaboratory comparison material
homogeneity testing
Authors: Pantelić Gordana K. , Todorović Dragana J. , Nikolić Jelena D. , Rajačić Milica M. 
Published: January 2015

Abstract
The homogeneity of fertilizer samples for
interlaboratory γ-ray spectrometry comparison was tested
by determination of the total γ count rate and the count
rates for two 238U γ lines, one 40K line and one common
235U and 226Ra line. Homogeneity testing was accomplished
by determination of the minimum, maximum, mean and
standard deviation for each parameter and comparison
of their standard deviations with predefined tolerances,
by Cochran’s test, and by a one-way ANOVA. The standard
deviations were all less than these tolerances. All samples
passed Cochran’s test and the one-way ANOVA test
for homogeneity.
Activated carbons for the removal of heavy metal
ions: A systematic review of recent literature
focused on lead and arsenic ions
Authors: Deliyanni Eleni A. , Kyzas George Z. , Triantafyllidis Kostas S. , Matis Kostas A. 
Published: January 2015

Abstract
This work is a systematic review of the literature
over the past decade of the application of activated
carbon (microporous or mesoporous) as adsorbents
for the removal of heavy metals, focusing especially
on lead (Pb) and arsenic (As) ions from the aqueous phase.
Classical examples from our lab are also given. Activated
carbon is known to provide a high surface area for adsorption.
Generally, surface modification is typically required, such as
oxidation, treatment with ammonia or even impregnation
with ferric ion, etc. and the adsorbent material may originate
from various sources. The pristine materials, after modification
and those after batch-wise adsorption, were characterized
by available techniques (BET analysis, Fourier transform
infrared spectroscopy, scanning electron microscopy,
thermal analyses, X-ray photoelectron spectroscopy).
Adsorption isotherms, thermodynamics and kinetics of
the process are also discussed. Selected studies from the
literature are examined in comparison with other adsorbents.
The role of chemistry in the metals adsorption/removal was
investigated.
An Underfrequency Load Shedding Scheme with Minimal Knowledge of System Parameters
Authors: Joe Athbel , Krishna S. 
Published: January 2015

Abstract
Underfrequency load shedding (UFLS) is a common practice to protect a power system during large generation deficit. The adaptive UFLS schemes proposed in the literature have the drawbacks such as requirement of transmission of local frequency measurements to a central location and knowledge of system parameters, such as inertia constant H and load damping constant D. In this paper, a UFLS scheme that uses only the local frequency measurements is proposed. The proposed method does not require prior knowledge of H and D. The scheme is developed for power systems with and without spinning reserve. The proposed scheme requires frequency measurements free from the oscillations at the swing mode frequencies. Use of an elliptic low pass filter to remove these oscillations is proposed. The scheme is tested on a 2 generator system and the 10 generator New England system. Performance of the scheme with power system stabilizer is also studied.
Evaluation of the adequacy of reference charts for the accurate identification of fetuses with bone length below the 5th percentile
Authors: de Carvalho Ana Alice Vidal , Carvalho José Antônio , Figueiredo Israel , Velarde Luis Guillermo , Marchiori Edson 
Published: January 2015

AbstractTo identify reference charts for femoral and humeral lengths enabling appropriate identification of fetuses <5Two samples of fetuses aged 14–40 weeks were selected from our institution’s ultrasonographic database. Regression analysis was used to construct reference charts of femoral and humeral lengths based on the local population (n=901). Femur and humerus length measurements from a second sample (n=1240) were transformed intoFor femoral length, one equation other than the local equation yieldedMost reference charts assessed underestimated the number of fetuses with long bone lengths <5
Cervical sonoelastography for improving prediction of preterm birth compared with cervical length measurement and fetal fibronectin test
Authors: von Schöning Dinah , Fischer Thomas , von Tucher Elisabeth , Slowinski Torsten , Weichert Alexander , Henrich Wolfgang , Thomas Anke 
Published: January 2015

AbstractAccurate prediction of the risk of spontaneous preterm birth is crucial for the clinical management of patients with preterm labor. The aim of the study was to investigate whether cervical sonoelastography improves prediction of spontaneous preterm birth compared with cervical length measurement and a fetal fibronectin (fFN) test.A prospective cohort study was conducted including 64 patients with preterm labor at 23–34 weeks of gestation. Patients had an fFN test and transvaginal cervical length measurement, followed by real-time cervical sonoelastography. The ratio of nondeformable tissue to the total area of a designed region of interest was analyzed and related to the gestational week of delivery.Cervical sonoelastography and fFN test show a significant correlation with spontaneous preterm delivery (P=0.007, P=0.001), resulting in 72.7%/36% sensitivity and 73%/95% specificity. The positive predictive value (PPV) was 61.5%/81.8% and the negative predictive value was 81.8%/70%. The cervical length was not different in cases with and without term delivery (P=0.165).Cervical sonoelastography is a promising technique that can complement routine diagnostic procedures to improve prediction of preterm birth. The PPV is improved by an fFN test.
Almanac W22340a From Uruk: The Latest Datable Cuneiform Tablet
Authors: Hunger Hermann , de Jong Teije 
Published: January 2015

Abstract:In this article we present a transliteration and translation of Tablet W22340a, an astronomical Almanac from Uruk. Based on the astronomical predictions in the text we suggest that it must be dated to the year 326 in the Arsacid Era, equivalent to 79/80 AD. This makes W22340a the latest datable cuneiform text uncovered so far. This dating confirms that cuneiform writing and astronomical scholarship persisted in Mesopotamia during the Arsacid period far into the first century AD, not only in Babylon but in Uruk as well.
An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease
Authors: Kizuka Yasuhiko , Kitazume Shinobu , Fujinawa Reiko , Saito Takashi , Iwata Nobuhisa , Saido Takaomi C , Nakano Miyako , Yamaguchi Yoshiki , Hashimoto Yasuhiro , Staufenbiel Matthias , Hatsuta Hiroyuki , Murayama Shigeo , Manya Hiroshi , Endo Tamao , Taniguchi Naoyuki 
Published: January 2015

AbstractThe β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1), an essential protease for the generation of amyloid‐β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). However, there is a concern that inhibiting BACE1 could also affect several physiological functions. Here, we show that BACE1 is modified with bisecting N‐acetylglucosamine (GlcNAc), a sugar modification highly expressed in brain, and demonstrate that AD patients have higher levels of bisecting GlcNAc on BACE1. Analysis of knockout mice lacking the biosynthetic enzyme for bisecting GlcNAc, GnT‐III (Mgat3), revealed that cleavage of Aβ‐precursor protein (APP) by BACE1 is reduced in these mice, resulting in a decrease in Aβ plaques and improved cognitive function. The lack of this modification directs BACE1 to late endosomes/lysosomes where it is less colocalized with APP, leading to accelerated lysosomal degradation. Notably, other BACE1 substrates, CHL1 and contactin‐2, are normally cleaved in GnT‐III‐deficient mice, suggesting that the effect of bisecting GlcNAc on BACE1 is selective to APP. Considering that GnT‐III‐deficient mice remain healthy, GnT‐III may be a novel and promising drug target for AD therapeutics.
An unusual case of an ACTH-secreting macroadenoma with a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene
Authors: Dinesen Pia T , Dal Jakob , Gabrovska Plamena , Gaustadnes Mette , Gravholt Claus H , Stals Karen , Denes Judit , Asa Sylvia L , Korbonits Márta , Jørgensen Jens O L 
Published: January 2015

Summary
A patient of Cushing's disease (CD) characterized by a large tumor and only subtle symptoms of hormonal hypersecretion was examined. The patient had a germline variant in the aryl hydrocarbon receptor-interacting protein (AIP) gene. A 50-year-old male presenting with headache was diagnosed with a large pituitary tumor by magnetic resonance imaging (MRI). His visual fields were intact and he exhibited no features of CD. Owing to an exuberant response to synacthen, an overnight dexamethasone suppression test was performed revealing inadequate suppression of plasma cortisol (419 nmol/l). Owing to tumor growth and visual field impairment, he underwent transsphenoidal surgery and developed hypocortisolemia. The pathology specimen revealed a sparsely granulated corticotrope adenoma. Postoperative MRI showed a large tumor remnant. The patient developed skin hyperpigmentation and a synacthen test demonstrated high basal and stimulated cortisol levels; an overnight dexamethasone suppression test showed no suppression (791 nmol/l) and elevated plasma ACTH levels (135 ng/l). A transcranial operation was performed followed by radiotherapy. Two months after radiotherapy, he developed secondary adrenocortical failure. Genetic testing revealed an AIP variant of unknown significance (p.R16H) without loss of the normal AIP allele in the tumor. A literature review showed ten CD patients with AIP gene variants, of whom five (including our case) were p.R16H. CD is occasionally dominated by pituitary tumor growth rather than symptoms of hypersecretion. The particular AIP gene variant identified in our patient is shared by four other reported cases of CD. Future studies are needed to assess whether the reported AIP gene variant is more than just coincidental.

Learning points

CD is occasionally dominated by pituitary tumor growth rather than symptoms of hypersecretion.

Resolution of both tumor remnant and hormonal hypersecretion may occur within 2 months after postoperative radiotherapy.

The particular AIP gene variant identified in our patient is shared by four other reported cases of CD.
La zona de integración fronteriza colombo – venezolana. La integración sostenible y el funcionalismo actual, un análisis descriptivo
Authors: Mora Ramírez Ángela Julieta 
Published: January 2015

El objetivo de esta investigación es realizar un estudio, sobre el concepto de integración sostenible, y desarrollar un análisis descriptivo de la Comunidad Andina, y la negociación comercial fronteriza de Colombia y Venezuela, zona Táchira( Venezuela) Norte de Santander (Colombia), desde la teoría funcionalista actual, y la integración sostenible. Hoy es necesario establecer criterios conjuntos de cooperación, y analizar, a partir de los conceptos, la integración total y sostenida, su importancia en el comercio y sus implicaciones actuales, ya sea por acuerdos binacionales, o, por acuerdos alternativos de cooperación que se fundan en estrategias supranacionales, que solidifican el proceso sin permearlo con situaciones coyunturales, y afectan el proceso mismo de negociación. También es necesario ver lo global desde lo local o regional; desde las fronteras, las cuales desarrollan un flujo de transacciones de altos volúmenes de productos y servicios; por tanto, se propone incrementar los estudios de lo local para lograr adaptarse a lo interdependiente.
Building the «Opium Evil» Consensus – The International Opium Commissionof Shanghai
Authors: Barop Helena 
Published: January 2015

Building the «Opium Evil» Consensus. The International Opium Commission of Shanghai Global narcotics control in the twentieth century developed based on the consensus that the use of drugs for non-medical purposes was morally despicable and therefore needed to be prohibited. This premise was first agreed upon by the International Opium Commission of Shanghai in 1909 and resulted from negotiations between delegations from China, the U.S. and the British Empire. Their differing perspectives on opium and on the opium trade shaped their positions of negotiation: all had to some extent experienced domestic opium problems but their economic interest in the opium trade did not align. Open negotiation and institutionalized international cooperation boosted moral arguments against what was conceived as the «opium evil». Under these conditions the U.S. and China managed to build the foundation for a prohibitive global narcotics regime that fit their purposes.
Revolution and Eternity. Introductory Remarks on Fascist Temporalities
Authors: Esposito Fernando , Reichardt Sven 
Published: January 2015

Revolution and Eternity. Introductory Remarks on Fascist Temporalities The special issue compares the central temporal concepts and chronopolitics of Italian Fascism, National Socialism and the Romanian Legion of the Archangel Michael. In our introduction we begin this venture by scrutinizing the fascist alternative to the narrative of progress, its obsession with dynamism and revolution and the cult of speed. These elements are juxtaposed with fascism's anti-historicism and its mythic longing for an eternal order. We show the close nexus between fascism's momentum and its quest to unearth an eternal entity – the nation or the Volk. We illustrate how the fascists united revolution and eternity, i.e. the destruction of the past with the restoration of origins, the beginning of a new era with the thousand-year standstill of time.
The Excavatory Intervention: Archaeology and the Chronopoliticsof Roman Antiquity in Fascist Italy
Authors: Arthurs Joshua 
Published: January 2015

The Excavatory Intervention: Archaeology and the Chronopolitics of Roman Antiquity in Fascist Italy Romanità – the invocation of the «eternal Roman spirit» – has long been recognised as a core component of Italian Fascist ideology and political culture. However, the «cult of Rome» is typically seen as an expression of the regime's theatricality, its retrograde tendencies and its hostility to modernity. This contribution argues that, on the contrary, romanità was part of Fascism's revolutionary vision of modernity. In particular, the article highlights the regime's use of archaeological excavation, both in Rome and in North Africa, as an instrument of spatial and temporal rupture, used to forge an unmediated relationship between Roman antiquity and Mussolini's New Italy.