bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of patient satisfaction after surgery for grade 1 degenerative spondylolisthesis: a 5-year analysis of the Quality Outcomes Database
Authors: Dru Alexander , Johnson Sarah E. , Linzey Joseph R. , Foley Kevin T. , Digiorgio Anthony , Alan Nima , Coric Domagoj , Potts Eric A. , Bisson Erica F. , Knightly John J. , Fu Kai-Ming , Shaffrey Mark E. , Weaver Jason , Bydon Mohamad , Chou Dean , Meyer Scott A. , Asher Anthony L. , Shaffrey Christopher I. , Slotkin Jonathan R. , Wang Michael Y. , Haid Regis W. , Glassman Steven D. , Virk Michael S. , Mummaneni Praveen V. , Park Paul 
Published: August 2024

OBJECTIVE
Lumbar decompression and/or fusion surgery is a common operation for symptomatic lumbar spondylolisthesis refractory to conservative management. Multiyear follow-up of patient outcomes can be difficult to obtain but allows for identification of preoperative patient characteristics associated with durable pain relief, improved functional outcome, and higher patient satisfaction.

METHODS
A query of the Quality Outcomes Database (QOD) low-grade spondylolisthesis module for patients who underwent surgery for grade 1 lumbar spondylolisthesis (from July 2014 to June 2016 at the 12 highest-enrolling sites) was used to identify patient satisfaction, as measured with the North American Spine Society (NASS) questionnaire, which uses a scale of 1–4. Patients were considered satisfied if they had a score ≤ 2. Multivariable logistic regression was performed to identify baseline demographic and clinical predictors of long-term satisfaction 5 years after surgery.

RESULTS
Of 573 eligible patients from a cohort of 608, patient satisfaction data were available for 81.2%. Satisfaction (NASS score of 1 or 2) was reported by 389 patients (83.7%) at 5-year follow-up. Satisfied patients were predominantly White and ambulation independent and had lower baseline BMI, lower back pain levels, lower Oswestry Disability Index (ODI) scores, and greater EQ-5D index scores at baseline when compared to the unsatisfied group. No significant differences in reoperation rates between groups were reported at 5 years. On multivariate analysis, patients who were independently ambulating at baseline had greater odds of long-term satisfaction (OR 1.12, p = 0.04). Patients who had higher 5-year ODI scores (OR 0.99, p < 0.01) and were uninsured (OR 0.43, p = 0.01) were less likely to report long-term satisfaction.

CONCLUSIONS
Lumbar surgery for the treatment of grade 1 spondylolisthesis can provide lasting pain relief with high patient satisfaction. Baseline independent ambulation is associated with a higher long-term satisfaction rate after surgery. Higher ODI scores at 5-year follow-up and uninsured status are associated with lower postoperative long-term satisfaction.
Durability of substantial clinical benefit leading to optimal outcomes in adult spinal deformity corrective surgery: a minimum 5-year analysis
Authors: Mir Jamshaid M. , Galetta Matthew S. , Alan Nima , Onafowokan Oluwatobi O. , Das Ankita , Dave Pooja , Tretiakov Peter , Lorentz Nathan A. , Lafage Renaud , Diebo Bassel , Janjua M. Burhan , Chou Dean , Smith Justin S. , Lafage Virginie , Schoenfeld Andrew J. , Sciubba Daniel , Demetriades Andreas K. , Passias Peter G. 
Published: August 2024

OBJECTIVE
The objective was to evaluate factors associated with the long-term durability of outcomes in adult spinal deformity (ASD) patients.

METHODS
Operative ASD patients fused from at least L1 to the sacrum with baseline (BL) to 5-year (5Y) follow-up were included. Substantial clinical benefit (SCB) in Oswestry Disability Index (ODI), numeric rating scale (NRS)–back, NRS-leg, and Scoliosis Research Society (SRS)–22r scores and physical component score were assessed on the basis of previously published values. Factors were evaluated on the basis of meeting optimal outcomes (OO) at 2 years (2+) and 5 years (5+). Furthermore, 2+ patients were isolated and evaluated on the basis of meeting OO at 5 years (2+5+) or not at 5 years (2+5−). OO were defined as follows: no reoperation, major mechanical failure, proximal junctional failure, and meeting either 1) SCB in terms of ODI score (decrease > 18.8) or 2) ODI < 15 and SRS-22r total > 4.5.

RESULTS
In total, 330 ASD patients met the inclusion criteria, with 45.5% meeting SCB for ODI at 2 years, while 46.0% met SCB at 5 years; 79% of those who achieved 2-year (2Y) SCB went on to achieve 5Y SCB. This rate was lower for OO, with 41% achieving 2Y OO (2+), while 37% met 5Y OO (5+) and 80% of 2+ patients had durable outcomes until 5+ (32% of the total cohort). Of the patient factors, frailty was significantly different among groups at 2 years, while comorbidity burden was significantly different at 5 years and the combination thereof differed in those with durable outcomes. Those who regained their level of activity postoperatively had 4 times higher odds of maintaining OO from 2 years to 5 years (p < 0.05). Osteoporosis rates, although equivocal at BL, were higher at the last follow-up in those who met 2Y OO but failed to meet 5Y OO. The odds of achieving OO at 5 years in 2+ patients decreased by 47% for each additional comorbidity and decreased by 74% in those who had lower-extremity paresthesias at BL (both p < 0.05). Controlling for patient factors and BL disability found fewer levels fused, decreased correction of sagittal vertical axis, and increased correction of pelvic incidence–lumbar lordosis mismatch to be predictive of maintaining 2Y OO until 5 years (p < 0.05).

CONCLUSIONS
SCB was met in 46% of ASD patients at 5 years. The durability of OO was seen in a third of patients until 5 years postoperatively. Higher rates of medical complications were seen in those who failed to achieve and maintain OO until 5 years. Frailty and comorbidity burden were significant factors associated with the achievement and durability of OO until 5 years.
Stereotactic radiosurgery for intracranial dural arteriovenous fistulas: patient outcomes and lessons learned over a 3-decade single-center experience
Authors: Peters Pierce A. , Naylor Ryan M. , Lanzino Giuseppe , Link Michael J. , Pollock Bruce E. 
Published: August 2024

OBJECTIVE
The role of stereotactic radiosurgery (SRS) in the management of intracranial dural arteriovenous fistula (dAVF) is unclear given the rarity of this lesion and the variability in treatment paradigms. This study describes a 3-decade experience with the SRS technique and its outcomes for patients with dAVF.

METHODS
The authors conducted a retrospective analysis of patients with dAVF who had undergone single-fraction SRS in the period from 1990 to 2021. The imaging modality initially used for targeting was angiography alone, then angiography plus MRI, and most recently MRI alone.

RESULTS
Two hundred twenty-two patients underwent SRS alone (n = 56, 25%) or SRS plus embolization (n = 166, 75%), depending on the severity of symptoms or the presence of cortical venous drainage (CVD). Most patients were women (64%), and the median patient age was 60 years. Common presenting symptoms were pulsatile bruit (55%), visual change or chemosis (21%), headache (10%), and intracerebral hemorrhage (5%). The most frequent dAVF location was the transverse or sigmoid sinus (44%), followed by the cavernous sinus (24%), jugular bulb (9%), and torcula (5%). CVD was noted in 28% of cases, and venous ectasia in 5%. Borden dAVF types among the patients were I (72%), II (20%), and III (8%). Cognard dAVF types among the patients were I (44%), IIa (27%), IIb (5%), IIa+b (15%), III (4%), and IV (5%).
The median SRS treatment volume was 7.6 cm3; the median margin and maximum doses were 18 and 36 Gy, respectively. Follow-up after SRS was available for 209 patients (median follow-up 31 months). Obliteration was noted in 75% of the patients (110/147) with follow-up vascular imaging; the median time to obliteration was 37 months. Multivariate analysis revealed that a cavernous sinus dAVF location was predictive of radiological obliteration (HR 1.86, 95% CI 1.08–3.18, p = 0.024). The absence of CVD was predictive of obliteration in subgroup analysis of non–cavernous sinus dAVF (HR 0.53, 95% CI 0.29–0.98, p = 0.04). Symptoms resolved in 86% of patients (160/185) with clinical follow-up. Twelve patients (5.4%) had complications related to angiography for SRS planning (n = 2, 0.9%), embolization (n = 3, 1.4%), post-SRS hemorrhage (n = 1, 0.5%), delayed sinus thrombosis (n = 1, 0.5%), radiation-induced tumors (n = 2, 0.9%), and chronic encapsulated expanding hematoma (n = 3, 1.4%).

CONCLUSIONS
SRS alone or in conjunction with embolization provided obliteration and symptom relief for the majority of patients with dAVF, with a low rate of procedure-related morbidity. Patients are at risk for late radiation-related complications, which can require treatment many years after SRS.
Implementing Multiple Intellegence Approach To Improve The Speaking Ability of The Eight Grade Students of SMP Negeri 3 Duampanua
Authors: Muliani  , Ammang Latifa  , Rafi'ah Nur  
Published: August 2024

The major problems of this research were how to enhance the students’ speaking ability. Then how to motivate the students to speak in English so this research conducted to find out whether implementing Multiple Intelligence effective to improve the students’ speaking of SMP Negeri 3 Duampanua.
A quasi-experimental method was carried out by researcher in this research. The population was the eight grade students of SMP Negeri 3 Duampanua. VIII.1 and VIII.2 were taken as sample which consists of 25 students for each class VIII.1 was chosen as the experimntal class, while VIII.2 was chosen as the control class. The instruments that used in collecting the data were interview test and questionnaire. The procedure in collecting data were divided into 3 stages namely pre-test, treatment, and post-test. The data obtained through the test were analyzed quantitatively and qualitatively.
The result of the research shows the students’ speaking ability of the experimental was better than the control group. It was proved by the data of the students’ mean score on experimental class was higher tha the control group (69.16 ˃ 60.52). Futhermore, implementing multiple intelligence improve the student speaking ability. Besides, the research finding also shows the students interest toward the implementing of this simulation. It was proved by the data from questionnaire that the students’ interest was which categorized as strongly agree.
Improving The Seventh Grade Students’ Vocabulary Mastery at UPTD SMP Negeri 22 Barru by Using Telegram Application
Authors: Yuliati Yuliati , Patahuddin Patahuddin , Patintingan Amir 
Published: August 2024

Based on observation, the researcher found that students’ vocabulary mastery relatively low where the big triggers was the learning media used by teacher. So that, the objective of this researcher was to measure whether the use of telegram application can improve the seventh grade students’ vocabulary mastery at UPTD SMP Negeri 22 Barru. In this research the researcher applied quasi-experimental method.The population of this research was the seventh grade students at UPTD SMP Negeri 22 Barru. The samples of the research taken using cluster random sampling technique, there are two classes as sample, experimental class and control class, both classes consisted of 28 students.The data was collect using vocabulary test (pre-test and post-test) and analyze employ statistical calculation to test the hypothesis. The result of this research shows that the mean score of pre-test was 45.35 and the post-test was 83.57. Besides the different score of pre-test and post-test, the mean score of the students in post-test 83.57 is higher than the Kriteria Ketuntasan Minimal (75) in UPTD SMP Negeri 22 Barru. The result of t-test value in post-test was 2.214 and t-table value was 1.684. It means that H1 was accepted and H0 was rejected and The seventh grade students at UPTD SMP Negeri 22 Barru who are taught by using telegram application is have better vocabulary mastery than the seventh grade students who are taught without using telegram application.
Ведення пацієнтів із легеневою гіпертензією в умовах воєнного стану: реалії та проблеми
Authors: Radchenko G. D. , Torbas O. O. , Botsiuk Yu. A. , Rekovets O. L. , Progonov S. O. , Sirenko Yu. M. 
Published: August 2024

Any military actions on the territory of any country can significantly influence on the quality of medical care. Especially, it could reflect on patients with rare diseases requiring expensive treatment. In this article there were analyzed the work of the specialized pulmonary hypertension (PH) center during the period of Russia’s military invasion in Ukraine and presented the results of the outpatient survey due to problems with patient access to medical care and medicine provision in the period from 24-Feb-2022 to 01-Jul-2024 (war period).We selected patients with a diagnosis of PH carried out for the periods: since 01-Jan-2018 until 30-Apr-2020 (pre-war and pre-COVID-19 period) and since 22-Feb-2022 until 01-Jul-2024 (war period): n=328 and n=394 respectively. The selection was made from the electronic hospital database and the electronic registry of patients that have been conducted in the department since 2014. With the help of the Google Form system, a questionnaire was created and sent through modern devices of communication (Viber, Facebook) to fill out online to patients who are registered (applied for outpatient or inpatient care) in the department or are subscribers to the social network accounts of the Ukrainian Association of Patients with Pulmonary hypertension and/or the Lviv City Charitable Foundation «Sisters of Dalili». We got 220 responses. It was established that martial law status in the country did not significantly affect the management of patients with different forms of PH in the specialized center. The number of treated patients and performed right heart catheterization procedures increased by 20 and 22 % respectively during the «war period», compared to the «pre-war» period. 65 % of PH patients who came abroad due to the war used the help of the specialized department for direct referral to PH centers in Poland for further treatment, including surgical one. 41,7 % of respondents changed their place of residence during the war, but only 17,9 % had interruptions in taking of drugs for the PH treatment. Along with the usual sources of free medicines (humanitarian aid from charitable organizations, the government’s free medicines program), one in five patients «shared out» medicines with other patients. In 45 % of the patients who visited foreign PH centers, the therapy previously prescribed in Ukraine was changed to more effective or safer drugs that are not registered in Ukraine.
Unique Pathology in the Locus Coeruleus of Individuals with Down Syndrome
Authors: Saternos Hannah , Hamlett Eric D. , Guzman Samuel , Head Elizabeth , Granholm Ann-Charlotte , Ledreux Aurélie 
Published: August 2024

Background: Down syndrome (DS) is one of the most commonly occurring chromosomal conditions. Most individuals with DS develop Alzheimer’s disease (AD) by 50 years of age. Recent evidence suggests that AD pathology in the locus coeruleus (LC) is an early event in sporadic AD. It is likely that the widespread axonal network of LC neurons contributes to the spread of tau pathology in the AD brain, although this has not been investigated in DS-AD. Objective: The main purpose of this study was to profile AD pathology and neuroinflammation in the LC, comparing AD and DS-AD in postmortem human tissues. Methods: We utilized immunofluorescence and semi-quantitative analyses of pTau (4 different forms), amyloid-β (Aβ), glial, and neuronal markers in the LC across 36 cases (control, DS-AD, and AD) to compare the different pathological profiles. Results: Oligomeric tau was highly elevated in DS-AD cases compared to LOAD or EOAD cases. The distribution of staining for pT231 was elevated in DS-AD and EOAD compared to the LOAD group. The DS-AD group exhibited increased Aβ immunostaining compared to AD cases. The number of tau-bearing neurons was also significantly different between the EOAD and DS-AD cases compared to the LOAD cases. Conclusions: While inflammation, pTau, and Aβ are all involved in AD pathology, their contribution to disease progression may differ depending on the diagnosis. Our results suggest that DS-AD and EOAD may be more similar in pathology than LOAD. Our study highlights unique avenues to further our understanding of the mechanisms governing AD neuropathology.
Metabolomic screening and urolithins metabotypes identification in the urinary metabolome of Costa Rican volunteers after blackberry (Rubus adenotrichos)-based drink consumption
Authors: Fallas-Ramirez José-Manuel , Baltodano-Viales Eleaneth , Mora-Román Juan-José , Hernandez Lorena , Pérez Ana M. , Vaillant Fabrice 
Published: August 2024

BACKGROUND: Besides providing nutritional value, functional foods have potential beneficial effects on health. Consumers worldwide seek food products with added value based on physical and mental well-being. OBJECTIVE: This study aimed to analyze the urinary metabolome of volunteers who consumed a drink based on Costa Rican blackberries ( Rubus adenotrichos) to identify the presence of urolithins and other possible bioactive compounds related to beneficial effects on health. METHODS: Fifteen healthy non-smoking male volunteers aged between 19 and 43 years old who consumed 250 ml of blackberry-based drink for breakfast for eight consecutive days were selected. Urine samples were obtained before and after drink consumption, which were submitted to analysis by Ultra-Performance Liquid Chromatography coupled to a Mass Detector (UPLC/ESI-Q-TOF-MS). Subsequently, a metabolomic analysis of the results was performed to identify the presence or absence of urolithins and other bioactive metabolites related to blackberry juice consumption. RESULTS: It was possible to detect high intensity presence of urolithin A ( n = 6) and high intensity presence of both urolithin A and B ( n = 5) in urine samples in several volunteers. However, finding them was impossible in others, or they were at very low intensities ( n = 4). Likewise, it was possible to identify Menth-1-en-4,8 diol glucuronide and 1-O-E-Cinnamoyl-(6-arabinosylglucose) as other compounds related to the consumption of blackberries. CONCLUSIONS: The consumption of Costa Rican blackberries allowed us to demonstrate the presence of three metabotypes within the study population: 40% of strong urolithin A (UAP) producers, 33.3% of both urolithin (A and B) producers (UBP), and 26.7% of weak urolithin A producers (0P). Finally, it is recommended to carry out more research in this regard, considering a greater number of volunteers and including people of both sexes.
PERAN DAN LANGKAH STRATEGI PARTAI POLITIK DALAM MENGIKUTI PEMILIHAN UMUM 2024
Authors: Iriani Dewi Dewi , Fauzan Muhammad Fauzan Muhammad , Budiono Arief Boediono Arief , Djabid Faisal Djabid Faisal , Hi Arsad Jamal Hi Arsad Jamal 
Published: August 2024

AbstrakPemilihan umum dipilih oleh rakyat yang diusulkan oleh partai politik ataupun gabungan dari berbagai partai pelaksanaan verifikasi pendaftaran dan pendataan partai politik yang dilakukan sejak bulan juli 2022. Partai politik yang lulus verifikasi sejumlah 18 partai, Partai politik yang telah lulus verifikasi tentunya akan mencari sosok calon calon perserta umum pemilihan. rumusan masalah 1). Bagiamana Peran Partai Politik Dalam Pemilihan Umum menurut Undang-undang No. 7 Tahun 2017 tentang Pemilihan Umum dan Undang-undang No 2 Tahun 2011 tentang Partai Poltik ? 2)Langkah strategi apa saja yang dilakukan partai politik dalam menentukan pilihan memenangkan calon calon perserta pemilihan umum? . Metode penelitian kualitatif, jenis penelitian yang menggunakan normatif suatu peraturan terkait partai politik dan pemilihan umum. pendekatan penelitian melalui perbandingan peraturan. Hasil Penelitian 1)U undang-undang No. 2 Tahun 2011 parpol organisasi dari sekelompok orang yang memiliki kesamaan tujuan dan cita-cita dalam memperjuangkan kepentingan anggota politik, dalam rakyat pemerintahan. Sedangkan undang-undang No 7 Tahun 2017 Pemilihan umum dalam sistem ketatanegaraan dilaksanakan secara demokatis dan berintergritas. 2) langkah strategis Partai politik untuk menentukan bakal calon partai politik umum adalah memilih ; memilih calon calon dari tokoh negarawan atau sejarawan, memilih calon calon dari tokoh partai politik dan memilih calon calon dari artis, pengenalan calon calon perserta pemilihan umum melalui berbagai macam media sosial. Saran / Rekomendasi : partai politik harus memilih dalam memilih bakal calon perserta pemilihan umum, karena calon terpilih akan menentukan politik bangsa . partai politik selalu mementingkan partainya diatas kepentingan rakyat. ________________________________________________________Kata Kunci ; Pemilihan Umum, Bakal Calon, Partai Politik
Teori Belajar Humanistik dan Implikasinya dalam Pembelajaran PAI
Authors: Iqbal Chailani Muchammad , Fahrub Abdul Wahab , Fitri Rohmatilah Luk Luki , Kurniawan Agus 
Published: August 2024

Pendidikan dan pengajaran adalah upaya sadar yang bertujuan untuk mengubah perilaku siswa menuju kedewasaan. Proses ini mencakup pengajaran yang membimbing siswa dalam pengembangan diri sesuai dengan tugas perkembangan mereka, yang meliputi kebutuhan individu, sosial, dan spiritual. Dalam konteks Islam, pendidikan memiliki orientasi humanistik yang menekankan nilai-nilai kemanusiaan. Namun, praktik pembelajaran saat ini di sekolah sering kali tidak memberikan ruang bagi siswa untuk mengembangkan kreativitas dan keterampilan berpikir kritis. Siswa sering diperlakukan sebagai objek yang hanya perlu diisi dengan pengetahuan tanpa kesempatan untuk eksplorasi dan kreativitas. Kritik terhadap metode ini menyoroti perlunya pendekatan pendidikan yang lebih efektif yang tidak memandang siswa sebagai wadah kosong, tetapi sebagai individu yang memerlukan dukungan dalam proses pembelajaran yang aktif dan kreatif. Pendekatan ini bertujuan untuk memanusiakan siswa dan memungkinkan mereka mengembangkan potensi diri mereka secara penuh. Teori humanistik, seperti yang diajukan oleh Abraham Maslow dan Carl Rogers, menekankan pentingnya memenuhi kebutuhan dasar manusia sebelum mencapai aktualisasi diri. Maslow mengklasifikasikan kebutuhan manusia dalam hierarki, mulai dari kebutuhan fisiologis hingga aktualisasi diri. Dalam konteks pembelajaran, pemenuhan kebutuhan ini penting agar siswa dapat belajar dengan optimal. Rogers menambahkan bahwa pembelajaran yang efektif harus melibatkan pengalaman pribadi siswa dan memberikan kebebasan untuk belajar tanpa tekanan atau paksaan. Guru berperan sebagai fasilitator yang mendukung siswa dalam proses belajar yang bermakna. Implementasi teori humanistik dalam PAI bertujuan untuk memanusiakan manusia melalui pendidikan yang demokratis dan partisipatif sehingga siswa mampu mengembangkan potensi dirinya secara maksimal, sejalan dengan tujuan utama dari teori belajar humanistik.
Kata-kata Kunci: pendidikan, humanistik, berpikir kritis.