bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gaps in the global protection of terrestrial genetic diversity
Authors: Schultz Jana Tabea , Geldmann Jonas , Theodoridis Spyros , Nogues-Bravo David 
Published: August 2024

AbstractIn recent decades, increased anthropogenic impact has led to a global decline in genetic diversity. Before the Kunming-Montreal Global Biodiversity Framework (2022), the absence of international consensus on how to directly assess and monitor genetic diversity, hampered large-scale conservation efforts. Scarcity of assessable genetic data has hindered the evaluation of conservation policies in safeguarding genetic diversity. This study presents the first global approach for evaluating the protection of genetic diversity. By examining the global distribution of mammalian intraspecific mitochondrial DNA and protected area coverage, we identify regions with high genetic diversity and insufficient protection coverage, e.g. regions of critical importance for biodiversity in the Brazilian Atlantic Forest. Additionally, we estimate the impact of global change scenarios on genetically diverse regions with a low degree of protection, revealing high vulnerability of areas in Central Africa. Nonetheless, integrating robust analysis into conservation planning remains challenging. Incorporating Macrogenetics into conservation planning holds the potential to reverse biodiversity decline.
Paradise under threat: the successful invasion of the freshwater shrimpNeocaridina davidiand its parasites on La Réunion Island
Authors: Prati Sebastian , Faivre Laetitia , de Mazancourt Valentin , Sures Bernd , Valade Pierre 
Published: August 2024

AbstractInvasive species are one of the major threats to global biodiversity, particularly in hotspots of endemic species, such as oceanic insular ecosystems. Tropical and subtropical islands are particularly vulnerable to biological invasions, with freshwater ecosystems expected to experience the most severe impacts. This is especially true if the insular freshwater fauna comprises a large set of near-threatened to critically endangered species.This study assesses the establishment of the pet-traded shrimpNeocaridina davidiand its parasites on the island of la Réunion, a biodiversity hotspot within the Malagasy region. We confirm the establishment of feralN. davidiin two river catchments. Moreover, we confirm the presence of the microsporidianEcytonucleospora hepatopenaei, an economically and ecologically relevant parasite that might impact a wide range of native species, including those living in brackish and marine environments. Three other microsporidians, two of which are unknown, have also been detected for the first time inN. davidi, raising concerns over possible spillover-spillback events. Therefore, we recommend timely actions to curb the spread ofN. davidiand its parasites in an effort to preserve the already endangered native freshwater fauna.
Unravelling a mechanistic link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in MPS VII
Authors: Mandal Nishan , Das Apurba , Datta Rupak 
Published: August 2024

SummaryProgressive neurodegeneration and cognitive disability are prominent symptoms of MPS VII, a lysosomal storage disorder caused by β-glucuronidase enzyme deficiency. Yet, the mechanism of neurodegeneration in MPS VII remains elusive thereby limiting the scope of targeted intervention. To address this, we recently developed a β-glucuronidase-deficient (CG2135-/-)Drosophilamodel of MPS VII. The CG2135-/-flies exhibited signs of neuromuscular degeneration, including loss of dopaminergic neurons, and accumulated engorged lysosomes, ubiquitinated proteins and mitochondria in their brains. These observations, coupled with our current finding that the CG2135-/-flies were highly susceptible to starvation, prompted us to investigate potential defects in the autophagy-lysosomal clearance machinery in the brain. We found that both autophagy induction and lysosome-mediated autophagosomal turnover were impaired in the CG2135-/-fly brain. This was evidenced by lower Atg8a-II levels, reduced Atg1 and Ref(2)P expression along with accumulation of lipofuscin-like inclusions and multilamellar bodies. Interestingly, mitophagy was also found to be defective in their brain, causing buildup of enlarged mitochondria with distorted cristae and reduced membrane potential. This, in turn, affected mitochondrial function as reflected by drastically reduced brain ATP levels. Energy depletion triggered apoptosis in neuronal as well as non-neuronal cells of the CG2135-/-fly brain, where we also detected apoptotic dopaminergic neurons. Resveratrol treatment, previously found to protect against loss of dopaminergic neurons in the CG2135-/-flies, has now been shown act by correcting the mitophagy defect and preventing ATP depletion. Collectively, our study establishes a causal link between mitophagy defect, mitochondrial malfunction, and apoptotic neurodegeneration in MPS VII.
Poly-alanine-tailing is a modifier of neurodegeneration caused by Listerin mutation
Authors: Hung Hao-Chih , Costas-Insua Carlos , Holbrook Sarah E. , Stauffer Jennifer E. , Martin Paige B. , Müller Tina A. , Schroeder David G. , Kigoshi-Tansho Yu , Xu Haifei , Rudolf Rüdiger , Cox Gregory A. , Joazeiro Claudio A. P. 
Published: August 2024

AbstractThe surveillance of translation is critical for the fitness of organisms from bacteria to humans. Ribosome-associated Quality Control (RQC) is a surveillance mechanism that promotes the elimination of truncated polypeptides, byproducts of ribosome stalling during translation. In canonical mammalian RQC, NEMF binds to the large ribosomal subunit and recruits the E3 ubiquitin ligase Listerin, which marks the nascent-chains for proteasomal degradation. NEMF additionally extends the nascent-chain’s C-terminus with poly-alanine (‘Ala-tail’), exposing lysines in the ribosomal exit tunnel for ubiquitination. In an alternative, Listerin-independent RQC pathway, released nascent-chains are targeted by Ala-tail-binding E3 ligases. While mutations in Listerin or in NEMF selectively elicit neurodegeneration in mice and humans, the physiological significance of Ala-tailing and its role in disease have remained unknown. Here, we report the analysis of mice in which NEMF’s Ala-tailing activity was selectively impaired. Whereas theNemfhomozygous mutation did not affect lifespan and only led to mild motor defects, genetic interaction analyses uncovered its synthetic lethal phenotype when combined with thelisterneurodegeneration-causing mutation. Conversely, thelisterphenotype was markedly improved when Ala-tailing capacity was partially reduced by a heterozygousNemfmutation. Providing a plausible mechanism for this striking switch from early neuroprotection to subsequent neurotoxicity, we found that RQC substrates that evade degradation form amyloid-like aggregates in an Ala-tail dependent fashion. These findings uncover a critical role for Ala-tailing in mammalian proteostasis, and deepen our molecular understanding of pathophysiological roles of RQC in neurodegeneration.
Research progress on protective performance evaluation and lifetime prediction of organic coatings
Authors: Hao Pan , Dun Yuchao , Gong Jiyun , Li Shenghui , Zhao Xuhui , Tang Yuming , Zuo Yu 
Published: August 2024

Purpose
Organic coatings are widely used for protecting metal equipment and structures from corrosion. Accurate detection and evaluation of the protective performance and service life of coatings are of great importance. This paper aims to review the research progress on performance evaluation and lifetime prediction of organic coatings.

Design/methodology/approach
First, the failure forms and aging testing methods of organic coatings are briefly introduced. Then, the technical status and the progress in the detection and evaluation of coating protective performance and the prediction of service life are mainly reviewed.

Findings
There are some key challenges and difficulties in this field, which are described in the end.

Originality/value
The progress is summarized from a variety of technical perspectives. Performance evaluation and lifetime prediction include both single-parameter and multi-parameter methods.
Enhancing cash flow management in Ghanaian financial institutions through effective corporate governance practices
Authors: Mensah Leviticus , Arhinful Richard , Owusu-Sarfo Jerry Seth 
Published: August 2024

Purpose
The purpose of this study was to leverage agency theory to examine the impact of board attributes on cash flow management in Ghana’s financial institutions.

Design/methodology/approach
Data for the study was collected from the annual published financial statements of selected financial institutions, which were obtained from their respective websites. The sampling technique used was purposive, resulting in the selection of 15 financial institutions in Ghana, of which 10 were listed on the Ghana Stock Exchange and 5 were non-listed. The study covered a period of 10 years, ranging from 2011 to 2020. The two-step generalized method of moments estimation was used to determine the relationship between the board attributes and cash flow management.

Findings
The study found that board size had a positive and significant influence on net cash flow from operating, investing and financing activities. The study also discovered that the proportion of nonexecutive directors had a positive and significant influence on net cash flow from operating, investing and financing activities. In addition, it was revealed that the proportion of female directors on the board exhibited a positive and significant influence on net cash flow from operating activities but a negative and significant influence on net cash flow from investing and financing activities.

Practical implications
The study recommends increasing female representation on corporate boards to 25%, as women bring valuable skills, knowledge and experience that positively impact the financial institutions’ cash flows.

Originality/value
This study focused on the impact of board attributes on cash flow management within Ghana. It explored how corporate governance affects strategic decisions related to cash flow management, contributing original insights to this field of research.
Where lean construction and offsite construction meet: a bibliographic scientometric analysis
Authors: Daniel Emmanuel Itodo , Babalola Anthony , Oladinrin Olugbenga Timo , Obi Lovelin Ifeoma , Oshodi Olalekan , Konara Mudiyanselage Ashendra Nikeshala 
Published: August 2024

Purpose
Improving construction projects' performance through innovative approaches such as lean construction (LC) and offsite construction (OSC) methods are at the centre of various debates. However, there is a limited understanding of the current link between LC and OSC approaches. This study aims to conduct a scientometric analysis on LC and OSC research to unpack and establish the nexus and suggest future research focus.

Design/methodology/approach
Scientometric analysis was used to systematically examine existing literature on LC and OSC to identify possible connections. Relevant publications were extracted from the Scopus database, using inclusion and exclusion criteria. VOSviewer software was used as a visualisation technique to analyse and map the interrelations and connections of the concepts being studied. Bibliograhic data on the 68 selected papers were extracted from the Scopus database.

Findings
The search results cover the period between 2003 and 2021. Descriptive statistics show that the number of published papers has increased yearly. Researchers in the USA and Canada are the most productive authors regarding the number of published papers. The directions for future research suggested are the need to identify best practices for integrating LC and OSC methods, the need for more interdisciplinary and cross-country collaboration among researchers, the use of alternative research methods will provide a better understanding of the benefit of integrating LC and OSC techniques and more research is needed to showcase how the use of lean and offsite construction can facilitate the attainment of net-zero in the construction industry.

Originality/value
This study provides insights into the trends and gaps in knowledge on integrating LC and OSC methods and offers valuable insights to scholars and practitioners in integrating LC and OSC principles. This knowledge is vital for identifying strategies to improve the outcome of construction projects and contribute to the sustainable socio-economic development of cities across the globe.
The influence of implicit self-theories on ChatGPT usage
Authors: Dinh Tam Duc 
Published: August 2024

PurposeThe advent of ChatGPT has fundamentally changed the way people approach and access information. While we are encouraged to embrace the tool for its various benefits, it is yet to be known how to drive people to adopt this technology, especially to improve their life skills. Using implicit self-theories, the current research delineated the distinct way incremental (vs entity) theorists use ChatGPT, which in turn influences their attitude and hence the behavioural intention towards this technology.Design/methodology/approachThe research employed a between-subject experimental design with 100 prolific participants. The manipulation materials were also pre-tested (N = 50). No confound effects such as content clarity, personal interest, and cognitive load were found. For the mediating effect, PROCESS Model 4 with bootstraps 5,000 and CI 95% were employed.FindingsIndividuals who believed that human ability to use technological applications was malleable, i.e. incremental theorists, were more likely to use ChatGPT to improve their life skills. On the other hand, when people believed that such an ability was fixed, i.e. entity theorist, they were less likely to use this new technology. The reason was that through the implicit belief, attitude towards ChatGPT was (more vs less) positively influenced which in turn motivated the behavioural intention. Further, the effect held beyond the impact of demographic factors such as age, gender, occupation, and educational level.Originality/valueEven though implicit self-theories have received tremendous interest and empirical support, be it generic or domain-specific, the effect of implicit belief in technological applications was not clearly determined. The current research helps to extend the implicit self-theories into the technological domain, and in this case, the usage of ChatGPT. Moreover, the full mediating effect of attitude offers some thought about the revised models of technology acceptance. That is, perhaps it is the combination of (implicit) belief and attitude that may have better predictive power for technological adoption behaviour.
An effective trajectory scheduling method for a 5-DOF hybrid machining robot
Authors: Liu Haitao , Zhou Junfu , Li Guangxi , Xiao Juliang , Zheng Xucang 
Published: August 2024

Purpose
This paper aims to present a new trajectory scheduling method to generate a smooth and continuous trajectory for a hybrid machining robot.

Design/methodology/approach
The trajectory scheduling method includes two steps. First, a G3 continuity local smoothing approach is proposed to smooth the toolpath. Then, considering the tool/joint motion and geometric error constraints, a jerk-continuous feedrate scheduling method is proposed to generate the trajectory.

Findings
The simulations and experiments are conducted on the hybrid robot TriMule-800. The simulation results demonstrate that this method is effectively applicable to machining trajectory scheduling for various parts and is computationally friendly. Moreover, it improves the robot machining speed and ensures smooth operation under constraints. The results of the S-shaped part machining experiment show that the resulting surface profile error is below 0.12 mm specified in the ISO standard, confirming that the proposed method can ensure the machining accuracy of the hybrid robot.

Originality/value
This paper implements an analytical local toolpath smoothing approach to address the non-high-order continuity problem of the toolpath expressed in G code. Meanwhile, the feedrate scheduling method addresses the segmented paths after local smoothing, achieving smooth and continuous trajectory generation to balance machining accuracy and machining efficiency.
Fuzzy financial risk analysis of net-zero transitions in public–private partnership projects in Ghana
Authors: Akomea-Frimpong Isaac , Jin Xiaohua , Osei-Kyei Robert 
Published: August 2024

Purpose
Among the topmost challenges, limiting the transformation of conventional public–private partnership (PPP) projects to meet net-zero targets is financial risk. This challenge is more prevalent in PPP projects in developing economies like Ghana, where financial investments have dwindled due to the recent COVID-19 recession. This paper aims to assess the key financial challenges in transitioning to net-zero PPP projects in Ghana.

Design/methodology/approach
The research method process was set as follows. First, a review of the literature to identify the major financial risks from journal articles, project reports and documents was undertaken, followed by questionnaire development and collection of data. Finally, the analysis of 134 questionnaire data was examined with the fuzzy synthetic evaluation.

Findings
The results indicate that the following financial challenges could hinder the transition to net-zero PPP projects in the country: increasing borrowing charges to build net-zero PPP projects due to the global covid-economic recession, poor project financial management, unstable local capital market and excessive labour, health and safety costs.

Research limitations/implications
Although, the study was conducted in Ghana, a country in the Sub-Saharan African region, the outcomes have significant impacts for similar developing countries in research investigations into the problem.

Practical implications
Assistance is provided in this study for PPP project practitioners in identifying the key financial challenges and possible strategies to mitigate them.

Originality/value
Towards net-zero sustainability, this study highlights the crucial financial barriers to overcome in the rapid transition to climate change and zero carbon solutions in PPP projects.
Exploring the feasibility of Muzara’ah based Islamic running finance model as an alternative for agriculture credit
Authors: Daud Hafiz Samiullah , Sharif Saqib 
Published: August 2024

Purpose
This study aims to highlight the issues encountered by Islamic Banking Institutions (IBIs) while financing the agriculture sector and explore the feasibility of Muzara’ah (crop sharing contract on partnership basis) model based on the concept of revolving credit as an alternative to current models.

Design/methodology/approach
To validate the proposed model and gauge the feasibility of Muzara’ah contract, a qualitative research method is applied based on 10 in-depth interviews with qualified industry experts and practitioners. These interviewees are selected following the purposive sampling method, and they belong to Sharīʿah board members of banking institutions, banking industry professionals engaged in agriculture lending, financial regulators (i.e. central bank personnel) and the farming community. Thematic analysis was applied to analyze the data.

Findings
The findings of this study document that Muzara’ah can be a useful alternative/solution for the growth of agriculture sector portfolio of financial institutions. Muzara’ah is cost-effective than other Islamic products, including Salam (a kind of sale in which payment is made on the spot while the delivery of the goods is deferred), and carries the features of revolving credit as offered by conventional banks/counterparts.

Research limitations/implications
The main limitation of the study is that only 10 in-depth interviews are conducted.

Practical implications
The application of the Sharīʿah compliant Muzara’ah model based on the concept of revolving credit could help increase agricultural productivity and revenues and reduce poverty and food insecurity. The research will help IBIs to develop products on the concept of Muzara’ah for farmers and other sectors of the agriculture industry.

Originality/value
To the best of the authors’ knowledge, Muzara’ah contract is not offered by formal banking institutions in Pakistan. Hence, the findings contribute to the existing literature and facilitate the policymakers and practitioners in implementing this financial product for the growth of the agriculture sector.
Exploring the role of an initiator in a population health management initiative: insights from action research
Authors: van Ede Anna Francisca Teresia Maria , Bruijnzeels Marc A. , Numans Mattijs E. , Stein K. Viktoria 
Published: August 2024

PurposeThe purpose of this paper is to present the learnings of a broker organization that started a new Population Health Management initiative in two regions in the Netherlands. The research focusses on the role of the broker organization itself in supporting stakeholders in the region to adopt a new implementation strategy designed by the broker organisation itself. The basis of this model was to organize, finance and monitor differently to improve the overall health of the population.Design/methodology/approachAn action research approach was chosen to support the endeavours of the broker organization and to acquire practical knowledge on the role of a third-party in PHM implementation. Qualitative data were collected from documentary analysis, focus groups, logbooks and observational data from team meetings.FindingsThe main result is that the role of the broker organization to implement PHM was subject to change during the more than two years of the research. Several themes emerged that influenced these role changes, both internal and external, showing the complexity of providing PHM implementation support as a third-party to regional stakeholders.Practical implicationsWe hypothesize that the role of a third-party changes depending on the maturity of the regional collaboration. The complexity of the transition in healthcare calls for constant adaptations, and thus learning and reflection, from all involved. Action research is a strong tool for this.Originality/valueThis paper is one of the first to report on the role of a third-party in PHM implementation. The action research methodology offered the right amount of flexibility to adhere to the complexity of the context and provided rich insights.