bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Possible Synergism Effect of Amoxyclav Combined with Gentamicin and Paracetamol against Blood Stream Escherichia coli
Authors: Abdullah Haider Yahya , Al-Khikani Falah Hasan Obayes , Karkaz Haider Mahdi , Abdulhussein Hawraa Ali 
Published: July 2024

Abstract

Background:
Some bacteria have developed resistance to antibiotics that were once commonly used to treat them. Escherichia coli is one of the most common causes of bloodstream bacterial infections. This research was performed to study the effect of some antibiotics on the growth of E. coli by combination with amoxyclav.

Materials and Methods:

E. coli were isolated from the blood stream of 20 patients and cultured in three media (blood agar, MacConkey agar, and eosin methylene blue agar). The cultures were incubated for 24 h at a temperature of 37°C. The well diffusion method used to evaluate the activity of antimicrobial agents. The antibiotics (paracetamol, gentamicin, and amoxyclav) were added separately in one petri dish and in combination with amoxyclav in another petri dish to evaluate the effect of antibiotics on bacterial growth before and after the addition of amoxyclav.

Results:
The study showed that males were more infected (65%) than females (35%), without significant differences (P = 0.18). The addition of amoxyclav increased the effect of gentamicin from 28.9 ± 2.7 to 33.7 ± 7.47 mm, showing significant differences (P = 0.013). The addition of paracetamol to amoxyclav showed antagonism, decreasing the effect from 31.75 + 9.41 to 29.95 ± 8.66 mm), without significant differences (P = 0.53).

Conclusions:
The combination of gentamicin with amoxyclav has a synergistic effect against E. coli clinically isolated from blood streams (P = 0.013). The addition of paracetamol to amoxyclav showed an antagonism effect, but it was still insignificant (P = 0.53).
Extensive Cerebral Venous Sinus Thrombosis during COVID-19 Infection in a Patient with Autoimmune Hyperthyroidism: A Case Report
Authors: Mnaili Mohamed Amine , Bourazza Ahmed 
Published: July 2024

Abstract

Cerebral venous sinus thrombosis (CVST) in the setting of coronavirus disease 2019 (COVID-19) is an uncommon phenomenon with increasing incidence. CVST is an uncommon subtype of stroke caused by thrombotic occlusion of the cerebral veins.
We report the case of an adult women with headache, fever, nausea, vomiting, and no known autoimmune diseases. Diagnostics revealed elevated infammatory and hypercoagulability markers, free T4, low TSHs, and positive SARS-CoV-2 PCR. Neuroimaging demonstrated a thrombosis of the superior sagittal sinus, both right and left transverse sinus extending into the right jugular vein.
A diagnosis of CVST with associated COVID-19 and hyperthyroidism was established.
In patients with suspected COVID-19, especially in the presence of causes of hypercoagulability and presence of atypical features, venous sinus thrombosis needs to be kept in mind in making the differential diagnosis. Follow-up examination revealed complete symptomatic resolution and regression of thrombosis.
Effectiveness of plasmapheresis educational and training program on nurses’ competency
Authors: Amein Naglaa M. , Elkodoos Rehab F. A. , Mostafa Heba A.-A. , Ismail Lamia M.-N. , Hegazy Mona A. E.-k. 
Published: July 2024

Background
The growing prevalence of plasmapheresis within global healthcare generates distinct challenges. Mastering the intricate technical aspects and specialized knowledge associated with this procedure necessitates an elevated level of competency among nurses. Therefore, educational and training programs serve as the cornerstone strategy to mitigate potential complications and foster robust professional awareness in this domain.

Aim
To determine the effectiveness of a plasmapheresis educational and training program on nurses’ competency.

Design
A quasi-experimental study design was used.

Setting
The study was carried out at the plasmapheresis unit in the renal and urology hospital’s dialysis department and at the blood bank unit of El-Minia University Hospital.

Sample
A purposive sampling of 40 nurses who met the inclusion criteria.

Tools
A structured interview questionnaire, self-administered knowledge questionnaire, and competency-based practice for nurses were the three methods used in the data collection process.

Results
The study’s findings demonstrated a statistically significant enhancement in the mean scores for knowledge and competency-based practice related to the plasmapheresis technique, following the implementation of an educational and training program. This is evidenced by a highly significant P value of 0.000.

Conclusion
Baseline data showed unsatisfactory levels of both theoretical knowledge and competency-based practice in the majority of participating nurses. Subsequent implementation of an educational and training program yielded significant improvements, as evidenced by the nurses’ demonstrably high levels of knowledge and competency-based practice on completion. These findings strongly support the efficacy of targeted educational interventions in enhancing nurses’ knowledge and clinical practice skills.

Recommendations
To ensure a consistently high level of nurse proficiency within healthcare agencies, regular implementation of competency training programs is recommended. Furthermore, ongoing advancements in nursing education should strive to seamlessly integrate quality and safety education throughout the curriculum, with a particular focus on practical applications within nursing practice settings.
Inter-rater reliability of auditory brainstem response waveforms elicited by complex stimuli
Authors: Johnson Christine , White Joanna D. 
Published: July 2024

Abstract

Objective:
The objective of this study was to assess the inter-rater reliability of peak marking for the frequency following the response portion of auditory brainstem response (ABR) waveforms elicited by complex stimuli.

Materials and Methods:
ABR testing was carried out on 30 adult participants with normal hearing, which generated a data set of 60 click-evoked waveforms and 60/da/-evoked waveforms. Three audiologists marked peaks for both click and/da/evoked ABR waveform data, derived from 30 participants aged 18–30 years. To assess inter-rater reliability, a two-way, random effects, single-measure model was used to calculate the intraclass correlation coefficients (ICCs).

Results:
The ICCs were ≥0.89 for peaks I, III, and V of the click-evoked waveforms. For the/da/evoked waveforms, the ICCs were rated good to high (≥0.83) for peaks V, A, E, F, and O, fair (0.75) for peak D but poor (≥0.45) for peak C.

Conclusion:
Investigations of reliability of waveform marking should be undertaken before using complex stimuli for ABR testing to prevent premature adoption of screening or diagnostic tools.
Prevention of residual dizziness after repositioning maneuvers for benign paroxysmal positional vertigo with a combination of cinnarizine and dimenhydrinate
Authors: Teggi Roberto , Familiari Marco , Cangiano Iacopo , Gatti Omar , Bussi Mario 
Published: July 2024

Abstract

Backgrounds:
Benign paroxysmal positional vertigo is a frequent complaint provoked by the detachment of otoconia from the utricle and their entry in a semicircular canal. Treatment is based on repositioning maneuvers; nonetheless, after successful maneuvers, some people refer an increase of instability without positioning vertigo or residual dizziness (RD).

Aims and Objectives:
To decrease the number of cases of RD and duration of symptoms, different pharmacological therapies have been proposed. We assessed the efficacy of cinnarizine 20 mg and dimenhydrinate 40 mg twice a day for 1 week as treatment for RD.

Materials and Methods:
We compared the presence and duration of RD in a sample of 177 patients treated with the association of cinnarizine 20 mg and dimenhydrinate 40 mg twice a day for 1 week after successful repositioning maneuvers with a sample of 118 nontreated subjects.

Results:
No difference was seen in age, anxiety, duration of vertigo before treatment, and frequency of migraine between the two groups. Treated subjects had a lower rate of RD (30.5% vs. 14.1%, P = 0.0006) and duration of symptoms when present (5 ± 4 vs. 9 ± 7 days). Among treated subjects, 35 (19.8%) reported drowsiness and dry mouth at the beginning of treatment but without the need to discontinue therapy.

Conclusions:
Our data support the hypothesis that this combination is useful in the prevention and therapy of RD.
Cytomorphological Features as a Subtyping Tool of Non-Small-Cell Lung Cancer in Brushing Bronchoscopic Samples
Authors: Gardić Nikola G. , Miljković Dejan M. , Lovrenski Aleksandra N. 
Published: July 2024

Background and Objective:
Nowadays, the separation of adenocarcinomas (ADCs) and squamous cell carcinomas (SCCs) is crucial given that there are new specific targeted therapies. So, the aim of this study was to examine the differences in cytomorphological features between ADC and SCC in bronchoscopic brush samples.

Material and Methods:
The retrospective study was conducted over a 3-year period at Western Balkan University Hospital. All brushing samples were analysed. According to the histopathological report, patients were classified into ADC and SCC groups. The cytomorphological features analysed in 95 samples were presence of necrosis, cell distribution, nuclear atypia, size of nuclei, and visibility of nucleoli. Statistical analysis was performed in JASP, and P values <0.05 were considered significant.

Results:
The necrotic background was more frequent in SCC samples. Small clusters sized ≤200 µm were found in 17.95% of samples from the SCC group and 53.57% in the ADC group. Large clusters sized >400 µm were found in 43.59% in the SCC group, while in the ADC group, it was found in 5.36%. There were no differences in nuclear atypia between groups. Nuclei that were >5x lymphocyte size were found more often in samples from ADC than in the SCC group (37.50 vs 10.25%). In 89.75% of samples from the SCC group, nuclei were ≤5x lymphocyte sizes, while in the ADC group, the percentage was 63.5%. Nucleoli were more often visible in samples from the ADC group compared to the SCC group (92.86% vs 64.10%, P < 0,05).

Conclusions:
Small clusters, large nuclei, and visible nucleoli were more frequent in the ADC group (P < 0.05), while large clusters, small nuclei, and invisible nucleoli were more frequent in the SCC group (P < 0.05).
Kontrowersje wokół nowelizacji ustawy o ochronie zabytków i opiece nad zabytkami w zakresie prowadzenia poszukiwań zabytków
Authors: Trzciński Maciej 
Published: July 2024

Nowelizacja ustawy z dnia 23 lipca 2003 r. o ochronie zabytków i opiece nad zabytkami dotycząca prowadzenia poszukiwań zabytków wzbudziła w środowisku naukowym, muzealniczym i konserwatorskim szereg kontrowersji. Projekt nowelizacji procedowany był latem 2023 r. jako projekt poselski w iście ekspresowym tempie, bez konsultacji społecznych. Zasadnicze, najbardziej dyskusyjne zmiany dotyczą zastąpienia obowiązującej procedury związanej z koniecznością uzyskania przez wnioskodawcę pozwolenia na poszukiwania zabytków, które wydaje właściwy miejscowo konserwator zabytków, mobilną aplikacją, przez którą ma być zgłaszana chęć prowadzenia poszukiwań. Aplikacja ta miałaby dopiero powstać. Znacznie ograniczono również obowiązki zgłaszającego, upraszczając całość procedury. Niepokoi też nowe rozwiązanie dotyczące przyznawania nagród (w tym nagród pieniężnych) za zabytki odkrywane podczas poszukiwań. Nowelizacja, mimo zdecydowanego sprzeciwu środowiska eksperckiego, zyskała poparcie Generalnego Konserwatora Zabytków. We wrześniu 2023 r. Prezydent podpisał ustawę, która miała wejść w życie 1 maja 2024 r.
Zespół pałacowo-parkowy w Lubostroniu pomnikiem historii
Authors: Nowicki Ryszard 
Published: July 2024

Rozporządzeniem prezydenta Rzeczypospolitej Polskiej z dnia 15 listopada 2023 r. zespół pałacowo-parkowy w Lubostroniu został uznany za pomnik historii. Klasycystyczna rezydencja Fryderyka hrabiego Skórzewskiego, wzniesiona w 1800 r., wzorowana na Villi Rotonda w pobliżu Vicenzy Andrei Palladia, otoczona założeniem parkowym w stylu angielskim, należy do najcenniejszych zabytków w skali Polski. Do 1939 r. obiekt był w posiadaniu przed stawicieli rodu Skórzewskich, pielęgnującego wartości patriotyczne i tradycje narodowe w okresie niewoli kraju. Po II wojnie światowej pałac został upaństwowiony. Wpisanie na listę pomników historii stanowi potwierdzenie wysokiej wartości zespołu pałacowo-parkowego, trwale związanego z historią Polski i polskim dziedzictwem kultury.
Zagrożenie dziedzictwa kulturowego przestępczością – analiza wydarzeń w 2022 roku (początek inwazji Rosji na Ukrainę)
Authors: Jakubowski Olgierd 
Published: July 2024

W artykule przedstawiono wybrane przypadki przestępstw w 2022 r. na tle statystyk Policji, Krajowej Administracji Skarbowej i Straży Granicznej. Będące częścią cyklu corocznych analiz opracowanie obrazuje tendencje i zagrożenia zabytków oraz dóbr kultury w danym roku. Komplementarne przedstawienie informacji o zagrożeniu dziedzictwa kulturowego przestępczością jest istotne dla badań mających na celu wypracowanie strategii jego ochrony. Na zagrożenie dziedzictwa kulturowego przestępczością mają wpływ szczególne wydarzenia, które oddziałują na poziom bezpieczeństwa w państwie. Wśród czynników, które trzeba wziąć pod uwagę, analizując zjawisko przestępczości przeciwko dziedzictwu kulturowemu w 2022 r., należy wskazać początek inwazji Rosji na Ukrainę.
Zjawisko „powracających ptaków” na polskim rynku sztuki. Aspekty ekonomiczno-prawne
Authors: Szafrański Wojciech 
Published: July 2024

Przez termin „powracające ptaki” należy rozumieć zjawisko polegające na powrocie na rynek aukcyjny dzieła sztuki (obiektu) niesprzedanego na wcześniejszej aukcji, wylicytowanego wcześniej warunkowo na aukcji, ale ostatecznie niesprzedanego, albo wcześniej fikcyjnie sprzedanego na aukcji. „Powracające ptaki” co do zasady skutkują w modelowym ujęciu trudnością sprzedania takich dzieł, tracą bowiem efekt świeżości dla uczestników aukcji. Wobec braku na polskim rynku aukcyjnym rozwiniętego systemu gwarancji próbą obrony przed spadkiem dzieł z aukcji i tzw. paleniem obiektów, są udawane transakcje warunkowe albo fikcyjne sprzedaże. W ten sposób rodzą się osobne typy „powracających ptaków”, oznaczone jako „zielone” i „czarne”. Ich funkcjonowanie na polskim rynku aukcyjnym wynika z braku prawnej odpowiedzialności domów aukcyjnych za wyniki aukcyjne i braku konstrukcji prawnej należytej staranności takich podmiotów w obrocie dziełami sztuki.
Issues of adaptation of medical simulation training specialists
Authors: Shiriaeva J. 
Published: July 2024

TThe article discusses issues of adaptation of medical simulation training specialists. When forming an adaptation system, one of the main tasks is the development of personnel adaptation regulations. For future regulation of the process of adaptation of the center’s specialists, types of adaptation in content, methods and activities, used in the Federal Accreditation Center of E. A. Wagner Perm State Medical University, a survey of specialists from simulation centers is planned. In the course of analyzing the responses received and previously identified methods and activities, a document will be prepared regulating the process of adaptation of medical simulation training specialists, which will further speed up the adaptation process and make it more effective for each party in the labor relationship.
Extraction of lithium from formation brines of oil and gas fields of Southern Mangyshlak
Authors: Итемен Н.М. , Муртазин Е.Ж. , Абсаметов М.К. 
Published: July 2024

Подземные воды всегда играли значительную роль в развитии экономики Казахстана. В последнее время, учитывая истощаемость месторождений полезных ископаемых и редкость некоторых элементов, все большее внимание уделяется промышленным водам. K промышленным относят подземные воды и рассолы, содержащие полезные компоненты или их соединения в количествах, обеспечивающих в пределах конкретных гидрогеологических районов (или их отдельных частей) рентабельную добычу и переработку этих вод с целью получения полезной продукции существующими техническими средствами с использованием современных технологических процессов. В статье изложены основные характеристики перспективных месторождений нефти и газа Южного Мангышлака. Приведены данные о содержании редких элементов в подземных водах на территории этой провинции.
Groundwater has always played a significant role in the development of the economy of Kazakhstan. Recently, given the depletion of mineral deposits and the rarity of some elements, more and more attention is paid to industrial waters. Industrial include groundwater and brines containing useful components or their compounds in quantities that ensure within specific hydrogeological regions (or their separate parts) cost-effective extraction and processing of these waters in order to obtain useful products by existing technical means and using modern technological processes. The article presents the main characteristics of promising oil and gas fields in the South Mangyshlak. Data on the content of rare elements in groundwater in the territory of this province are given.
Cuadros y carteles para enseñar a leer: materialidad, disputas político-pedagógicas y prácticas de enseñanza en las escuelas de la ciudad de Buenos Aires a fines del siglo XIX
Authors: Spregelburd Roberta Paula 
Published: July 2024

La práctica de exponer carteles con letras y sílabas en las paredes de las aulas estaba presente desde sus primeras configuraciones, sin embargo, hacia fines del siglo XIX, se produjo una renovación en los soportes materiales destinados en la enseñanza inicial de la lectura que innovaba en cuanto a su diseño, sus fundamentos pedagógicos y los métodos de enseñanza.
El artículo analiza tres colecciones de carteles aprobados por el Consejo Nacional de Educación para uso en la jurisdicción nacional:
- Los Carteles de lectura y logografía, de Francisco Berra.
- Los carteles El Nene, de Andrés Ferreyra.
- Los carteles El Alfa, de Eleodoro Suárez.
Las tres colecciones coinciden en la imposición de la enseñanza simultánea de la lectura y la escritura, el sustento en el concepto pestalozziano de intuición (en algunos aspectos, articulado con elementos positivistas) y la primacía del concepto de “lectura inteligente” sobre la “lectura mecánica”. La combinación de estos componentes nos lleva a plantear que se trata de soportes materiales modernos. Por otra parte, a pesar de que los autores coincidían en la importancia del método de “palabra generadora” diferían en cuanto a los procedimientos más efectivos para implementarlo.
Como último punto de análisis, el artículo se refiere a lo que efectivamente sucedía dentro de las aulas de la ciudad de Buenos Aires, donde el uso de los carteles dependía de la interacción con otras dimensiones que afectan las prácticas pedagógicas, como por ejemplo la disponibilidad y conservación de estos materiales didácticos así como la apropiación particular que hacían los/as maestros y maestras.
Revisiting the evolution of downhill thunderstorms over Beijing: a new perspective from a radar wind profiler mesonet
Authors: Guo Xiaoran , Guo Jianping , Chen Tianmeng , Li Ning , Zhang Fan , Sun Yuping 
Published: July 2024

Abstract. Downhill thunderstorms frequently occur in Beijing during the rainy seasons, leading to substantial precipitation. The accurate intensity prediction of these events remains a challenge, partly attributed to insufficient observational studies that unveil the thermodynamic and dynamic structures along the vertical direction. This study provides a comprehensive methodology for identifying both enhanced and dissipated downhill thunderstorms. In addition, a radar wind profiler (RWP) mesonet has been built in Beijing to characterize the pre-storm environment downstream of the thunderstorms at the foothill. This involves deriving vertical distributions of high-resolution horizontal divergence and vertical motion from the horizontal wind profiles measured by the RWP mesonet. A case study of an enhanced downhill thunderstorm on 28 September 2018 is carried out for comparison with a dissipated downhill thunderstorm on 23 June 2018, supporting the notion that a deep convergence layer detected by the RWP mesonet, combined with the enhanced southerly flow, favors the intensification of thunderstorms. Statistical analyses based on radar reflectivity from April to September 2018–2021 have shown that a total of 63 thunderstorm events tend to be enhanced when entering the plain, accounting for about 66 % of the total number of downhill thunderstorm events. A critical region for intensified thunderstorms lies on the downslope side of the mountains west to Beijing. The evolution of a downhill storm is associated with the dynamic conditions over the plain compared to its initial morphology. Strong westerly winds and divergence in the middle of troposphere exert a critical influence on the enhancement of convection, while low-level divergence may lead to dissipation. The findings underscore the significant role of an RWP mesonet in elucidating the evolution of a downhill storm.
Evaluating the representation of Arctic cirrus solar radiative effects in the Integrated Forecasting System with airborne measurements
Authors: Röttenbacher Johannes , Ehrlich André , Müller Hanno , Ewald Florian , Luebke Anna E. , Kirbus Benjamin , Hogan Robin J. , Wendisch Manfred 
Published: July 2024

Abstract. In two case studies, airborne measurements of broadband solar irradiances above and below Arctic cirrus are compared to simulations of the Integrated Forecasting System (IFS) operated by the European Centre for Medium-Range Weather Forecasts (ECMWF) using offline runs of ECMWF's operational radiation scheme, “ecRad”. Furthermore, independent of the solar irradiances, cirrus properties are derived from collocated airborne active remote sensing observations to evaluate the optical and microphysical parameterizations in ecRad. The data were collected in the central Arctic over sea ice (81–90° N) with instrumentation installed aboard the High Altitude LOng range research aircraft (HALO) during a campaign in March and April 2022. Among others, the HALO instrumentation included upward- and downward-looking pyranometers to measure broadband solar irradiances, a cloud radar, and a multi-wavelength water vapour differential absorption lidar. Extended horizontal flight legs above and below single-layer cirrus were performed. The solar radiation measurements are used to evaluate ecRad in two case studies of optically thin and thick cirrus, with an average transmissivity of 0.9 and 0.6, respectively. Different ice optics parameterizations optionally available in ecRad are applied to test the match between simulation and measurements. Furthermore, the IFS-predicted ice water content and ice effective radius are replaced by values retrieved with the radar and lidar. The choice of ice optics parameterizations does not significantly improve the model–measurement agreement. However, introducing the retrieved ice microphysical properties brings measured and modelled irradiances in closer agreement for the optically thin cirrus, while the optically thick cirrus case is simulated as too thick. It is concluded that the ice water content simulated by the IFS is realistic and that the mismatch between observed and simulated solar irradiances mostly originates from the assumed or parameterized ice effective radius.