bluuebunny/crossref_metadata_2025_split huggingface dataset:
Report of chronic myeloid leukemia in chronic phase from Tata Memorial Hospital, Mumbai, 2002-2008
Authors: Parikh Purvish 
Published: December 2013

Abstract
Background: Chronic myeloid leukemia (CML) is the commonest hematological malignancy in India. This manuscript is a single center analysis CML in chronic phase (CP). Materials and Methods: We did retrospective analysis of almost 1000 patients registered as chronic myeloid leukemia over a period of 6 years at Tata Memorial Hospital. Results: We found striking difference in cytogenetic response among patients presenting in late chronic phase (CP) compared with the patients in early CP. The rate of complete cytogenetic response among patients in late CP was 60% while in early CP it was 80%, which was statistically significant (P = 0.0001). The overall survival was 86%, at a median follow-up of 51 months. Innovator glivec was taken by 671 patients among which complete cytogenetic response (CCyR) was seen in 72% whereas generic veenat was taken by 237 patients and CCyR was seen in 75% of them. Conclusion: Availability of imatinib has dramatically changed the outlook for CML in India. The response was identical for those treated with innovator brand of imatinib as compared to the generic brand. Hence quality generics provide a cost effective solution, which is particularly relevant in the current global scenario.
Report of chronic myeloid leukemia in chronic phase from Eastern India, Institute of Hematology and Transfusion Medicine, Kolkata, 2001-2009
Authors: Ray Siddhartha Sankar , Chakraborty Prantar , Chaudhuri Utpal ,   Ganesh
Published: December 2013

AbstractThe data 192 patients from Eastern India, Kolkata center was presented in Indian cooperative oncology network meeting, out of which 97% patients were diagnosed in the chronic phase. Complete hematological response was seen in 70.5% among patients and 86% of patients were in clinical and hematological remission over 5 years with a median follow-up of 4.85 years.
Report of chronic myeloid leukemia from SEAROC experience, Jaipur over a period of 9 years
Authors: Maru Anish 
Published: December 2013

AbstractSEAROC cancer center presented the data 387 patients from the city of Jaipur. This oncology center caters large number of population from Jaipur as well as from neighboring states. Out of the 387 patients, 334 (86%) patients were in chronic phase. Complete hematological response was seen in 368 (95%) of patients and no response in 5 patients. Among these patients, 33 (8.5%) progressed to blast crisis.
A short report on chronic myeloid leukemia from Post Graduate Institute of Medical Education and Research, Chandigarh
Authors: Malhotra Pankaj , Varma Neelam , Varma Subhash 
Published: December 2013

AbstractPost Graduate Institute (PGI) Chandigarh is a premier institute of North India. There are approximately 70,000 admissions per year. The adult clinical hematology department sees more than 2000 new patients per year. A preliminary analysis of 299 chronic myeloid leukemia patients registered from January 2001 until December 2007 was done. Out of these, 256 (86%) patients were in chronic phase (CP). The median age at presentation was 40 years. At 6 months of follow-up 95% of patients who were started on Imatinib mesylate based therapy remained in CP. Partial cytogenetic remission was seen in 69% of patients while complete cytogenetic response was seen in only 20% of patients at 6 months on Imatinib mesylate.
The treatment of chronic myeloid leukemia, data from Gujarat Cancer and Research Institute, Ahmedabad
Authors: Shah Sandip A 
Published: December 2013

AbstractGujarat Cancer and Research Institute, Ahmedabad presented data of total 840 patients, out of which 775 (90%) were in chronic phase. Complete hematological response (CHR) was seen in 96% of patients and median time to achieve (CHR) was 2 months. Complete cytogenetic response was seen in 36%.
Report of patients with chronic myeloid leukemia Kidwai Memorial Institute of Oncology, Bangalore over 15 years
Authors: Babu Govind 
Published: December 2013

AbstractKidwai Memorial Institute of Bangalore is one of the most comprehensive and major regional cancer center. It was established in 1974 and caters population not only from Karnataka, but also from Tamil Nadu, Andhra Pradesh. They presented the data of 540 patients out of which 95% patients were in chronic phase. Complete hematological response was seen in 98.45 of patients. Overall survival at 5 years was 86.5%.101 patients has suboptimal response were considered for and underwent mutational analysis, out of which 27 patients showed various mutations and are mentioned elaborately in the article.
Report of chronic myeloid leukemia in chronic phase from Omega Hospital and Indo-American Centre, Hyderabad, 2004-2010
Authors: Dattatreya P S , Nirni S S 
Published: December 2013

AbstractOmega hospital and Indo-American Center from Hyderabad presented a data of 55 patients with chronic myeloid leukemia 87% (48) patients were in chronic phase. 5% (3) patients had primary resistance, while 64% (36) had shown good response to imatinib. At a median follow-up of 36 months 73% (40) of patients were in chronic phase.
Report of chronic myeloid leukemia in chronic phase from Dr. Senthil Rajappa, 2002-2009
Authors: Rajappa Senthil , Varadpande Lalit , Paul Tara Roshni , Jacob Rachel Thomas , Digumarti Raghunadharao 
Published: December 2013

AbstractNizam′s Institute of Medical Science is a premier institute of Hyderabad, established in 1980. The Medical Oncology Unit is the 1 st comprehensive cancer center established for the state of Andhra Pradesh. The department has presented a data of total 201 patients with the median age of 32 at diagnosis. Among these 66 (33%) patients belonged to low Hasford risk group. Complete hematologic response was seen in 195 (97%) of patients. The progression free survival (PFS) was 77% for all patients while those who achieved complete cytogenetic response, PFS was 88% at 29 months.
Imatinib mesylate resistance and mutations: An Indian experience
Authors: Srivastava Shweta , Dutt Sarjana 
Published: December 2013

AbstractThe treatment of chronic myeloid leukemia (CML) has been revolutionized by the small molecule selective kinase inhibitor imatinib mesylate. Imanitib was the first BCR-ABL targeted agent approved for the treatment of CML patients and confers significant response in most patients; however, a substantial number of patients are initially refractory to the drug or may develop resistance during the course of treatment. Point mutations in the kinase domain (KD) of BCR-ABL that impact drug binding have been identified as one of the major mechanisms of resistance. We present here an overview of the current practice in monitoring for such mutations, including the methods used, criteria for investigating and guidelines for reporting the mutations. We further present and discuss the experience of our own laboratory in studying the KD mutations in Indian CML patients on imatinib treatment.
Therapeutic drug monitoring for imatinib: Current status and Indian experience
Authors: Arora Brijesh , Gota Vikram , Menon Hari , Sengar Manju , Nair Reena , Patial Pankaj , Banavali S D 
Published: December 2013

AbstractImatinib is the current gold standard for treatment of chronic myeloid leukemia (CML). Recent pharmacokinetic studies have shown considerable variability in trough concentrations of imatinib due to variations in its metabolism, poor compliance, or drug-drug interactions and highlighted its impact on clinical response. A trough level close to 1000 ng/mL, appears to be correlated with better cytogenetic and molecular responses. Therapeutic Drug Monitoring (TDM) for imatinib may provide useful added information on efficacy, safety and compliance than clinical assessment alone and help in clinical decision making. It may be particularly helpful in patients with suboptimal response to treatment or treatment failure, severe or rare adverse events, possible drug interactions, or suspected nonadherence. Further prospective studies are needed to confirm relationship between imatinib plasma concentrations with response, and to define effective plasma concentrations in different patient populations.
Obstetrics-Gynecology Resident Attitudes and Perceptions About Chronic Pelvic Pain: A Targeted Needs Assessment to Aid Curriculum Development
Authors: Witzeman Kathryn A. , Kopfman Jenifer E. 
Published: December 2013

Abstract

Background
Chronic pelvic pain (CPP) accounts for 10% of gynecologic visits and is a common complaint in university-based and community resident clinics. Resident education about CPP has been inconsistent, and review of the limited literature shows predominantly negative perceptions of patients with CPP. Current literature lacks information regarding obstetrics-gynecology residents' attitudes and acquired knowledge regarding CPP.

Objective
This targeted needs assessment aims to identify regional obstetrics-gynecology resident attitudes and self-perceived knowledge regarding chronic pelvic pain in order to better address potential educational barriers and look toward placing a greater emphasis on this area in resident training.

Methods
We conducted a focus group of obstetrics-gynecology residents to identify major themes regarding attitudes about CPP. This informed the development of a survey administered to university-based and community-based obstetrics-gynecology residents (N  =  57) in the Colorado part of the Western Mountain Region. Cronbach α was calculated to determine reliability for each theme, and descriptive statistics were calculated for each theme. Independent samples t tests assessed differences between training levels and between university and community training sites.

Results
Survey response rate was 72% (41 of 57). Residents consistently reported feeling overwhelmed by CPP patients, perceived a lack of time to see these patients, and indicated a desire to learn more in this area, but they varied in chosen learning methods. No significant differences were found between levels of training or training sites.

Conclusions
Most obstetrics-gynecology residents surveyed believe they are inadequately prepared to address the needs of women presenting with CPP.
O Isomorfismo na Educação Ambiental como Tema Transversal em Programas de Graduação em Administração
Authors: Silva Heloísa Helena Marques da , Campanario Milton Abreu , Souza Maria Tereza Saraiva de 
Published: December 2013

A Política Nacional de Educação Ambiental determina a inclusão da Educação Ambiental em todos os níveis do ensino de modo transversal e contínuo, vedando sua utilização como disciplina específica. O referencial teórico está assentado no isomorfismo aplicado ao tema da transversalidade em Instituições de Ensino Superior (IES), buscando identificar os mecanismos que as impulsionam a mudar de comportamento frente a essa regulamentação, desvendando quais forças promovem a incorporação da educação ambiental na grade da graduação em Administração, como tema transversal. A metodologia utilizada é quantitativo-qualitativa e utiliza um estudo multicaso junto a quatro IES, com Graduação em Administração. Conclui-se que pressão isomórfica coercitiva, por parte da sociedade, e normativa, ligada à atuação profissional, são as que mais contribuem para a institucionalização da educação ambiental na grade curricular. As demandas sociais para formação do administrador com conhecimentos ambientais é o fator mais forte neste processo.
Is it Possible to Teach Entrepreneurship? Comparative Analysis with Brazilian Students
Authors: De Muylder Cristiana Fernandes , Dias Alexandre Teixeira , Oliveira Cláudio Luiz de Souza 
Published: December 2013

Is it possible to teach someone to become an entrepreneur? It is this question that motivated this field survey in a Brazilian entrepreneurial training high school. A quantitative survey was carried out with a population of 313 students of the chosen school, being that 175 students were freshmen and 138 graduates. It was possible to observe that the freshmen and the graduate students confirm that the education and training that they received in the school, did contribute to become entrepreneurs, although a few divergences were described. The students considered that innovating capacity, dealing with risks and gain professional maturity was important factors to achieve success within organizations or businesses. It was suggested new study comparing schools that do not have, as also to carry out studies in other countries with different cultural characteristics.
Teaching entrepreneurship students the practice of innovation: A brain-based guided experience approach
Authors: Degen Ronald Jean 
Published: December 2013

This paper presents a new method for teaching entrepreneurship students to practice innovation and to create high-impact business opportunities. The teaching method is based on the guided experience learning model that was developed by Caine et al. (2009) to develop the executive functions in the brains of learners, and on the innovation framework that was introduced by Verganti (2009). The cognitive perspective of creativity, as explained by Weisberg (2006), is used to show how the practice of innovation can be learned. The model used for the creative process is based on research by Wallas (1926), and on recent neurological findings on the deliberate and spontaneous pathways to creativity (Carson, 2010). The concept of effectual process (SARASVATHY, 2008) provides an approach to the validation of the students’ radical innovation ideas.
Toxicity of endosulfan on embryo-larval development of the South American toad Rhinella arenarum
Authors: Svartz Gabriela V. , Wolkowicz Ianina R. Hutler , Coll Cristina S. Pérez 
Published: December 2013

Abstract

Endosulfan is a widely used pesticide despite its extreme toxicity to a variety of taxa and its worldwide ban. The aim of the present study was to evaluate the acute and chronic toxicity of endosulfan on the embryonic-larval development of the common South American toad Rhinella arenarum. The results showed that lethal and sublethal effects increased with concentration and exposure time. The sensitivity to endosulfan increased during the larval period, the complete operculum stage (S.25) being the most sensitive (504-h median lethal concentration [LC50] = 0.01 mg endosulfan/L; 10% lethal concentration [LC10] = 0.004 mg endosulfan/L). Endosulfan exposure caused morphological abnormalities such as general underdevelopment, edema, gill malformations, and cellular dissociation as well as neurotoxicity. Our results also showed that larvae exposed to concentrations of 0.005 mg endosulfan/L and 0.01 mg endosulfan/L completed metamorphosis earlier than controls, but with underdevelopment. The 240-h teratogenic index was 6.13, implying a high risk for embryos to be malformed in the absence of significant embryonic lethality. Because the hazard quotients for chronic exposure were over 1, the level of concern value and toxicity endpoints obtained in the present study for R. arenarum occurred at concentrations lower than the levels of endosulfan reported in the environment, this pesticide should be considered a potential risk for this species. Environ Toxicol Chem 2014;33:875–881. © 2013 SETAC
Using Hexagenia in sediment bioassays: Methods, applicability, and relative sensitivity
Authors: Harwood Amanda D. , Rothert Amanda K. , Lydy Michael J. 
Published: December 2013

Abstract

The majority of sediment toxicity and aquatic bioaccumulation assessments are conducted using standardized species, such as Hyalella azteca, Chironomus dilutus, and Lumbriculus variegatus. The burrowing mayfly, Hexagenia sp., may serve as an ideal supplemental organism for both toxicity and bioaccumulation studies for several reasons. Hexagenia are recognized as sensitive species, have a long aquatic life stage (up to 2 yr), and have large bodies, which aid in retrieval from sediments and for residue analysis. The present study outlines the authors' established method for collecting and hatching eggs, raising nymphs, and using these animals for toxicity testing. Furthermore, the relative sensitivity of 3 size classes of Hexagenia to a representative contaminant (bifenthrin) was examined and compared with laboratory-derived median lethal concentrations for the more traditionally used Hyalella and Chironomus. Finally, sublethal end points, including immobilization and suspended solids, were defined for this species. This provides guidance for the use of this species in toxicological bioassays. Environ Toxicol Chem 2014;33:868–874. © 2013 SETAC
Molded polymer‐coated composite bone void filler improves tobramycin controlled release kinetics
Authors: Brooks Benjamin D. , Sinclair Kristofer D. , Davidoff Sherry N. , Lawson Scott , Williams Alex G. , Coats Brittany , Grainger David W. , Brooks Amanda E. 
Published: December 2013

AbstractInfection remains a significant problem associated with biomedical implants and orthopedic surgeries, especially in revision total joint replacements. Recent advances in antibiotic‐releasing bone void fillers (BVF) provide new opportunities to address these types of device‐related orthopedic infections that often lead to substantial economic burdens and reduced quality of life. We report improvements made in fabrication and scalability of an antibiotic‐releasing polycaprolactone‐calcium carbonate/phosphate ceramic composite BVF using a new solvent‐free, molten‐cast fabrication process. This strategy provides the ability to tailor drug release kinetics from the BVF composite based on modifications of the inorganic substrate and/or the polymeric component, allowing extended tobramycin release at bactericidal concentrations. The mechanical properties of the new BVF composite are comparable to many reported BVFs and validate the relative homogeneity of fabrication. Most importantly, fabrication quality controls are correlated with favorable drug release kinetics, providing bactericidal activity to 10 weeks in vitro when the polycaprolactone component exceeds 98% w/w of the total polymer fraction. Furthermore, in a time kill study, tobramycin‐releasing composite fragments inhibited S. aureus growth over 48 h at inoculums as high as 109 CFU/mL. This customizable antibiotic‐releasing BVF polymer‐inorganic biomaterial should provide osseointegrative and osteoconductive properties while contributing antimicrobial protection to orthopedic sites requiring the use of bone void fillers. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1074–1083, 2014.
Stability analysis of uncertain switched singular time‐delay systems with discrete and distributed delays
Authors: Zamani Iman , Shafiee Masoud 
Published: December 2013

SummaryThe issues of stability analysis of a class of continuous uncertain switched singular time‐delay systems consisting of discrete and distributed delays is investigated in this paper. Based on the LMIs, constructing the new extended Lyapunov‐like Krasovskii functional, and the average dwell‐time approach, delay‐dependent sufficient conditions are derived to check the stability of such systems. By solving the corresponding LMIs, the average dwell‐time and switching signal condition are obtained. This paper also highlights the relationship between the average dwell‐time of the switched singular time‐delay system, exponential rate of differential, and algebraic states. Two numerical examples show the effectiveness of the proposed design method. Copyright © 2013 John Wiley & Sons, Ltd.
Solid‐state foaming of carbon fiber/polypropylene/nano‐CACO3 composite using supercritical CO2
Authors: Wang Chuanbao , Ying Sanjiu 
Published: December 2013

AbstractIn this work, nano‐CaCO3 was used to improve the foamability of carbon fiber (CF)/polypropylene (PP) composite in solid‐state foaming using supercritical CO2. The CF content was maintained at 15 wt% and four concentrations of nano‐CaCO3 content, 1, 3, 5 and 8phr, were used. The surface of nano‐CaCO3 was firstly treated by silane coupling agent. By the way, the properties of the nano‐composites with various nano‐CaCO3 contents were analyzed by scanning electron microscope (SEM), differential scanning calorimeter (DSC), and torque rheometer. Before foaming, the gas absorption experiment was done using gravimetric method. Concerning on determination of the foaming conditions, it is found that 175°C and 60s were suitable as foaming temperature and time. Furthermore, we can also find that the foamed composites with 3phr nano‐CaCO3 showed the smallest mean cell diameter and largest cell density compared with the other nano‐CaCO3 contents under the given saturation condition. In addition, the mean cell diameter decreased while cell density increased as saturation pressure increased because of the higher gas solubility in the composites. When the saturation pressure was 25MPa, the mean cell diameter and cell density with 3phr nano‐CaCO3 were 17μm and 2.20×107cells/cm3, respectively. POLYM. COMPOS., 35:1723–1735, 2014. © 2013 Society of Plastics Engineers
Prevalence of extrauterine pelvic lesions on transvaginal ultrasound in asymptomatic 20–39‐year‐old women
Authors: Jokubkiene L. , Sladkevicius P. , Valentin L. 
Published: December 2013

ABSTRACTObjectivesTo estimate the prevalence of extrauterine pelvic lesions on transvaginal ultrasound examination of gynecologically asymptomatic women of fertile age, and to compare this prevalence between women with spontaneous menstrual cycles, those using the combined oral contraceptive (COC) pill and those using a gestagen intrauterine contraceptive device (IUD).MethodsSix hundred and forty‐four gynecologically asymptomatic 20–39‐year‐old Caucasian women with no current or previous gynecological problems, who were recruited from a Swedish population registry, were examined with transvaginal ultrasound on cycle day 4–8. Our definition of ovarian cyst was a unilocular cyst with anechoic cyst contents ≥ 35 mm in mean diameter, or any other type of intraovarian lesion. The prevalence of extrauterine pelvic lesions was compared between women not using hormonal contraception and those using COC or a gestagen IUD.ResultsOvarian lesions were found in 24 (3.7%) women. One woman had bilateral ovarian lesions. An ultrasound diagnosis of paraovarian cyst was made in 41 (6.4%) women, of peritoneal cyst in four (0.6%) women and of hydrosalpinx in one (0.2%) woman. All incidentally detected lesions had a mean diameter of ≤ 5 cm. One 17‐mm intraovarian lesion was suspicious for malignancy, and histology confirmed a Sertoli–Leydig cell tumor. The ultrasound diagnoses in the remaining 23 women were endometrioma (n = 10 (1.6%)), dermoid cyst (n = 5 (0.8%)), cystadenofibroma (n = 1 (0.2%)), mature teratoma (n = 1 (0.2%)) and functional cyst, i.e. a cyst that resolved within 3–5 months (n = 6 (0.9%)). Four women with an ultrasound diagnosis of a benign lesion were operated on, and the ultrasound diagnoses of endometrioma (n = 2), dermoid cyst (n = 1) and mature teratoma (n = 1) were confirmed histologically. The prevalence of persisting ovarian lesions was highest in women with spontaneous menstrual cycles (4.4% vs 0.9% and 0% in women using COC and gestagen IUD, respectively; P = 0.025), but age was the only factor independently associated with persisting ovarian masses, the prevalence increasing with age.ConclusionsBenign ovarian lesions are found in about 1 in 25 gynecologically asymptomatic women aged 20–39 years with no history of gynecological disease. To be able to offer optimal management of such masses, their natural history needs to be elucidated in a large prospective observational study. Copyright © 2013 ISUOG. Published by John Wiley & Sons Ltd