bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regional Eruptive Neurofibromas
Authors: Betti Roberto , Cerr Amilcare , Gualandri Lorenzo , Moneghini Laura , Crosti Carlo 
Published: April 2015

AbstractA 71‐year‐old woman presented with multiple, flesh‐colored, papular lesions on the left dorsal side of the hand which had erupted 5 years earlier. No café‐au‐lait spots, freckles, or Lisch nodules were detected. Family history did not disclose neurofibromas or abnormal pigmentation. Two biopsy specimens of the lesions showed circumscribed, non‐encapsulated neurofibromas. Segmental neurofibromatosis is characterized by the unilateral, segmental appearance of neurofibromas and/or café‐au‐lait spots in the absence of genetic transmission. The authors discuss the significance of localized multiple cutaneous neurofibromas in the absence of family history and suggest the possibility of a cutaneous hamartoma.
Mo2+ HLA‐DR– Monocytosis in Varicella Zoster Virus Infection
Authors: Horiuchi Yasuhiro 
Published: April 2015

AbstractTwo‐color analysis using Mo2 (CD14) monocytes and HLA‐DR class II monoclonal antibodies confirmed monocytosis in varicella zoster virus (VZV) infection in eight cases of herpes zoster and two cases of varicella. Only three cases, one being varicella, showed extensive Mo2+ HLA‐DR– monocytosis of more than 12%. Accordingly, monocytosis in VZV infection may not be specific to the VZV antigen.
Secretion of Different Types of Gelatinases from Cultured Human Keratinocytes
Authors: Kobayashi Takashi , Hattori Shunji , Nagai Yutaka , Sakuraoka Koichi , Nishikawa Takeji 
Published: April 2015

AbstractWe investigated gelatinolytic enzymes derived from cultured human keratinocytes. Using a zymograph, we detected 92 kDa and 72 kDa gelatinases as major components and 83 kDa as a minor component from a conditioned cultured medium (BSL‐K110, Kyokutoseiyaku Co.) of keratinocytes. After several passages, the 72 kDa band disappeared, and the 83 kDa band became dominant in another conditioned culture medium (K‐GM, Kurashikibouseki Co.); these keratinocytes had a relatively differentiated appearance. These results suggest that some mechanism may regulate the secretion of selected types of gelatinase from keratinocytes under different conditions.
Evaluation of an Avidin‐Biotin‐Peroxidase Method with a Monoclonal Antibody to Type IV Collagen in the Differential Diagnosis of Bullous Pemphigoid and Epidermolysis Bullosa Acquisita
Authors: Bowszyc‐Dmochowska Monika , Hashimoto Takashi , Dmochowski Marian , Nishikawa Takeji 
Published: April 2015

AbstractThere are reports in which an immunohistochemical technique with a monoclonal antibody to type IV collagen has been employed for differentiating between bullous pemphigoid (BP) and epidermolysis bullosa acquisita (EBA). The aim of this study was to determine whether this method could be used routinely. Biopsies (paraffin‐embedded lesional skin containing a blister) from currently diagnosed patients with clinical features suggesting BP or EBA were examined by an avidin‐biotin‐peroxidase (ABC) technique. Sera were tested by indirect immunofluorescence on salt‐split skin (IF) and immunoblotting (IB). In all cases which exhibited clear type IV collagen staining, the results of the ABC technique agreed with results of both IF and IB. In one confirmed EBA case, it was impossible to unequivocally localize type IV collagen, because it stained very faintly. Taking into consideration the results of our study, data indicating that the level of blistering might not coincide with the localization of immunoreactants in EBA cases and the possibility of an enzymatic destruction of lamina densa, we conclude that the ABC method is unsuitable for differentiation between BP and EBA.
Hormonal Profiles and Prevalence of Polycystic Ovary Syndrome in Women with Acne
Authors: Timpatanapong Penwadee , Rojanasakul Aram 
Published: April 2015

AbstractOne of the important etiologic factors in acne is an increase in sebaceous gland activity, which is androgen dependent. Acne is a common manifestation of hyperandrogenemia. Therefore, acne may not only cause cosmetic concern but may also be a sign of underlying disease. In females, the most common cause of hyperandrogenemia is polycystic ovary syndrome (PCOS). The purpose of this study was to determine the hormonal profiles of women with acne and the prevalence of PCOS in women attending the dermatological clinic with acne problems.The diagnostic criteria of PCOS were clinical findings of menstrual disturbances and hyperandrogenism (acne, seborrhea, hirsutism), pelvic ultrasound imaging of PCO (multiple subcapsular ovarian cysts 2–8 mm. in diameter, with dense echogenic stroma), and an elevated luteinizing hormone (LH) to follicle stimulating hormone (FSH) ratio. There were 51 women with acne; 20 regularly menstruating volunteers without acne served as a control group.PCOS was found in 19 out of 51 patients with acne (37.3%) and none of the control group. Twenty acne patients had abnormal menstruation (39.2%). Acne cases had higher mean levels of serum total testosterone (T), free T, dehydroepiandrosterone sulfate (DHEAS) and prolactin (PRL). No statistically significant difference was observed for LH, FSH or sex hormone binding globulin (SHBG).Because of this high prevalence of PCOS in women with acne, all women presenting with acne should be asked about their menstrual pattern and examined for other signs of hyperandrogenemia. Hormonal profile determination as well as pelvic ultrasonography for ovarian visualization should be performed to confirm the diagnosis of PCOS in female acne patients who have menstrual disturbances.
Natural History of Psoriasis: A Study from the Indian Subcontinent
Authors: Kaur Inderjeet , Handa Sanjeev , Kumar Bhushan 
Published: April 2015

AbstractClinical and epidemiological data from 1220 patients with psoriasis is presented. Psoriatics accounted for 2.3% of the total dermatology outpatients. There was a distinct male preponderance. Mean age of onset was lower in women at 27.6 years, although the severity of the disease was the same in both sexes. Family history was positive in just 2% of patients.Plaque type disease was the most common, seen in over 93% of the patients. Lesional pruritus was a problem in 65%. Remission in summer was experienced by 43%. The scalp was the first site of onset in 25.2%. Nail and joint involvement were seen in 55.7% and 4.4%, respectively. Complete remission of disease activity was experienced by 35% of the patients during some part of the year in the course of their disease.
Panniculitis with Eosinophilic Infiltration Due to Gabexate Mesilate (FOY®): Possibility of Allergic Reaction
Authors: Nakayama Fumiaki 
Published: April 2015

AbstractA 59‐year‐old Japanese man developed septal panniculitis with eosinophilic infiltration in both forearms and the dorsum of the left hand after a gabexate mesilate intraveous drip infusion for acute pancreatitis through catheters implanted in these sites. Gabexate mesilate at a dose of 1000 mg per day had been given continuously for 8 days, and antibiotics were added by the same infusion route twice a day. All the infusion routes, however, became occluded one after the other. Reddish swelling first occurred at the left wrist 6 hours after occlusion of the infusion route, and, on both forearms, reddish swelling occurred about one week after the occlusion of each route. Patch testing revealed a ++ reaction to gabexate mesilate (10% pet) at days 3 and 7, and skin testing revealed indurated erythema to gabexate mesilate (0.1% aq) at days 2 and 3. The specimens biopsied from the positive skin testing reaction sites showed perivascular infiltrate and slight septal panniculitis. The inflammatory infiltrate consisted predominantly of lymphocytes with small numbers of eosinophils. Staining of the specimen biopsied from the right forearm lesion with anti‐eosinophil cationic protein (ECP) antibodies (EG1 and EG2) showed deposition of eosinophil‐derived granule proteins at the damaged septal connective tissues of the panniculitis. The panniculitis improved with topical steroid treatment. This case suggested that the concentration of infused gabexate mesilate may have been high enough to damage blood vessels and that gabexate mesilate may have leaked into the surrounding connective tissues, inducing allergic reactions and resulting in leions.
Traumatic Aneurysm of the Temporal Artery: A Report of Five Cases
Authors: Inoue Yuji , Iwamoto Takashi , Kitoh Masato , Yoshimura Kouji , Ono Tomomichi 
Published: April 2015

AbstractFive cases of traumatic aneurysm of the superficial temporal artery are reported. Four patients clearly stated that they had sustained traumatic injuries within 3 months prior to the appearance of the pulsating aneurysms; in the remaining case, more than two years had passed before the appearance of the nodule, and it was without pulsation. Color Doppler echography was very useful for observing the circulation in these aneurysms. Histologically, these cases were pseudoaneurysms composed of small vessels with internal elastic lamina and adjacent connective tissue proliferation, suggesting a break in the arterial wall.
A Unique Case of Squamous Cell Carcinoma Showing Adenocarcinomatous Features with Focal Apocrine Differentiation
Authors: Yamamoto Osamu , Yasuda Hiroshi , Murayama Minoru , Asahi Masakazu 
Published: April 2015

AbstractWe report an 85‐year‐old man with squamous cell carcinoma on the right pinna. Two years after the excision of the lesion, metastatic foci were found extending from the right retromandibular to the mastoid region and into the parapharyngeal space. Histopathologically, the primary tumor showed interconnecting nests of atypical cells invading into the dermis from multiple epidermal and infundibular foci. The tumor had both squamous and glandular differentiation. A peculiar finding was the presence of decapitation secretion in the glandular foci. To our knowledge, definite apocrine differentiation in squamous cell carcinoma has not previously been reported.
A Case of Dermatopathia Pigmentosa Reticularis
Authors: Bux Tai‐Sung , Kim Young‐Keun , Whang Kyu‐Uang 
Published: April 2015

AbstractDermatopathia pigmentosa reticularis (DPR) is a very rare disorder with the diagnostic triad of generalized reticulate hyperpigmentation, noncicatricial alopecia, and onychodystrophy. Many other dermatologic findings have been associated with this triad, including adermatoglyphia, hypohidrosis or hyperhidrosis, palmoplantar hyperkeratosis, and nonscarring blisters on the dorsa of the hands and feet. The mode of inheritance is unclear but may be autosomally dominant. To our knowledge, only 11 cases have been reported in the world, and none has previously been described in the Orient. We present a Korean patient with the typical features of the DPR triad, along with adermatoglyphia, hypohidrosis, and nonscarring blisters on the dorsa of the feet.
Ulcerative Lichen Planus: A Rare Variant of Lichen Planus
Authors: Isogai Zenzo , Koashi Yusuke , Sunohara Akiyo , Tsuji Takuo 
Published: April 2015

AbstractA 54‐year‐old Japanese man with ulcerative lichen planus is reported. He had a painful erythema with ulcers on his soles and nail dystrophy. Mucous involvement was present on his lip. His hairs were intact. Histopathological findings confirmed the diagnosis of lichen planus.
A Case of Estrogen Dermatitis
Authors: Kim Kab‐Hyeong , Yoon Tae‐Jin , Oh Chee‐Won , Kim Tae‐Heung 
Published: April 2015

AbstractA 29‐year‐old Korean woman had erythematous papular patches on her face for six months. The eruptions recurred in a cyclic fashion along with her menstruation. The patient responded positively to an intradermal skin test for estrogen and showed marked improvement with the antiestrogen drug, Tamoxifen. We concluded that sensitivity to her own estrogen caused this dermatitis, that an intradermal skin test with progesterone and estrogen should be carried out routinely in patients with cyclic premenstrual flares, and that tamoxifen can be used as a specific therapy. To the best of our knowledge, this woman is the first patient with estrogen dermatitis reported in Korea.
Disaggregation of Corneocytes from Surfactant‐treated Sheets of Stratum Corneum in Hyperkeratosis on Psoriasis, Ichthyosis Vulgaris and Atopic Dermatitis
Authors: Shukuwa Tetsuo , Kligman Albert M. 
Published: April 2015

AbstractTo elucidate the pathogenesis of impaired barrier function and the influence of surfactant on the stratum corneum in hyperkeratosis, we investigated morphological alterations of the corneocytes with soap solution. Groups of five patients each with psoriasis vulgaris (PV), ichthyosis vulgaris (IV), atopic dermatitis (AD), and normal controls were examined. Four samples of the horny layer were obtained from the same site by cyanoacrylate adhesive biopsy. The first sample was used for the superficial layer, and the fourth, for the basal horny layers. Each sample was agitated in 1% stirred soap solution at 60°C. The number and size of isolated corneocytes and the morphologic changes were investigated. The release of corneocytes was greater and the swelling and morphological changes of corneocytes exposed to soap solutions were less in PV and AD than in IV or in healthy subjects. In IV, the release was markedly less than in controls. The release and swelling were greater in the superficial than in the basal horny layers.It was concluded that the cohesiveness of corneocytes was probably less in PV and AD and greater in IV than in normals. It was also suggested that the cohesion of corneocytes from the superficial horny layer was less than that from the deep layer. The permeability of the cornified envelope in PV and AD patients was less than in IV or healthy subjects. It was confirmed that highly potent soaps induce loss of many corneocytes and reduce the barrier function of the stratum corneum.
Langerhans Cell Histiocytosis (Histiocytosis X) with Morphologic Expression of Desmosomes and Microvillous Structures
Authors: Furukawa Masuyo , Suzuki Hiroyuki 
Published: April 2015

AbstractAn unusual case of Langerhans cell histiocytosis in a 7‐year‐old female is presented. She had ultrastructural evidence of desmosomal biogenesis and formation of gland‐like structures by lesional cells; their apical plasma membranes were folded into large numbers of microvilli. Despite the presence of these structures characteristic of epithelial cells, an infiltrated plaque on the abdominal skin of this patient was interpreted as cutaneous involvement of multiple system Langerhans cell histiocytosis because the immunohistochemical staining of the lesional cells for CD1a, S100, PNA, CD4, EN‐4, and HLA‐DR was positive, and numerous Birbeck granules were ultrastructurally identified in some lesional cells. Other clinical data included the presence of scaly erythematous skin lesions on the forehead and lytic osseous lesions in the maxilla, which were also histologically diagnosed as Langerhans cell histiocytosis. The absence of any internal malignancy in this patient readily ruled out the other diagnostic possibility of a metastatic adenocarcinoma showing glandular differentiation with brush border morphogenesis. The possibility that the desmosome‐linked lesional epithelioid cells were actually cells of sweat glands entrapped in the histiocytic proliferation was also ruled out. The functional significance of the desmosomes and microvillous structures in the present case of Langerhans cell histiocytosis remains to be clarified. Awareness of this variant of Langerhans cell histiocytosis will be important for averting potential misdiagnosis in favor of epithelial tumors, especially metastatic adenocarcinomas.
Concurrent Cytomegalovirus, M. Tuberculosis and M. Avium‐Intracellulare Cutaneous Infection in an HIV Patient
Authors: Núñez María , Miralles Enrique S. , Hilara Yolanda , Pintado Vicente , Harto Antonio , Ledo Antonio 
Published: April 2015

AbstractWe report a 25‐year‐old HIV‐positive man with a past medical history of disseminated cytomegalovirus (CMV) infection, who developed cutaneous lesions during a disseminated mycobacterium infection. The histological changes of CMV and acid‐fast bacilli were seen on histopathology of the lesions. Cultures were positive for M. tuberculosis and M. avium‐intracellulare (MAI). CMV is frequently isolated from HIV patients, but skin involvement is rare. The association of CMV and mycobacteria can occur in cutaneous lesions of AIDS patients, but concurrent cutaneous involvement of CMV, M. tuberculosis, and MAI is unusual. These findings emphasize the polymorphous presentation of infectious disorders in AIDS patients and the need for multiple biopsies and for special stains in such patients.
Plantar Thrombotic Nodules with Marked Neovascularization in Diabetes: A Symptom Which Has Been Overlooked?
Authors: Akimoto Sachiko , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbsractA 69‐year‐old woman with diabetes has had multiple subcutaneous nodules on the soles for 11 months. She suffered from uncontrolled diabetes mellitus, hypercholesteremia, and cardiovascular thrombosis and had a past history of photocoagulation therapy for proliferative diabetic retinopathy. Histological examination revealed vascular thrombosis surrounded by neovascularization in the subcutaneous tissue. The basement membranes of vessels were thickened and strongly stained with periodic acid‐Schiff. An increased serum concentration of von Willebrand factor antigen was observed. With control of her diabetes, the nodules almost disappeared. Her curious skin manifestation is speculated to be a diabetes‐mellitus‐related change in which endothelial injury and the subsequent induction of angiogenetic factors may play important roles. It is possible that this kind of skin manifestation has been overlooked or not examined histopathologically.
Penicillamine‐Induced Degenerative Dermatoses: Report of a Case and Brief Review of Such Dermatoses
Authors: Iozumi Ken , Nakagawa Hidemi , Tamaki Kunihiko 
Published: April 2015

AbstractWe describe a case of elastosis perforans serpiginosa with additional findings of degenerative skin changes. A 20‐year‐old man with hepatolenticular degeneration, under prolonged treatment with D‐penicillamine, presented with a circular or serpiginous arrangement of nuchal papules. Histopathologically, transepidermal channels were accompanied by granulomatous reactions, with several giant cells engulfing elastic fibers. In addition to these findings of a typical elastosis perforans serpiginosa, we observed scar‐like skin changes inside the circular arrangement of the papules. At the scar‐like tissue, we found electron‐microscopical evidence of randomly aggregated thin collagen fibers with no tendency toward systemic combined bundle formation, which is a characteristic feature of normal collagen fiber formation. Pseudoxanthoma‐elasticum‐like changes were observed on his neck. On his axillae and groin, slight skin thickening and wrinkling were detected. The diagnosis of elastosis perforans serpiginosa does not represent all of the manifestations or the pathological background described above. The skin manifestations described here represent not only an elastosis but also a total degenerative dermatosis with over‐healed collagenosis. Thus, those dermatoses should be summarized as one entity, penicillamine‐induced degenerative dermatosis. After considering the pathogenic background and clinical similarities, we further propose to simplify the penicillamine‐induced skin manifestations to three categories: acute sensitivity reactions, bullous dermatoses, and degenerative dermatoses.
Pneumomediastinum and Subcutaneous Emphysema Associated with Fatal Interstitial Pneumonia in Dermatomyositis
Authors: Nagai Yayoi , Ishikawa Osamu , Miyachi Yoshiki 
Published: April 2015

AbstractWe described a 65‐year‐old woman who died of acute interstitial pneumonia associated with dermatomyositis. Subcutaneous emphysema and pneumomediastinum simultaneously developed. The association of the pulmonary rupture with vasculitis has been assumed as the common cause in interstitial pneumonia. Diffuse alveolar damage, however, might have led to the pneumomediastinum and subcutaneous emphysema in our patient, who had no signs of cutaneous vasculitis.
Critical Evaluation of Food and Mite Allergy in the Management of Atopic Dermatitis
Authors: Hanifin Jon M. 
Published: April 2015

AbstractThe subject of allergic causation of atopic dermatitis (AD) has been a source of controversy for over sixty years. While there is general agreement of allergen‐induced asthma and allergic rhinoconjunctivitis, AD lesions cannot be readily or consistently induced by foods and inhalants. The most consistent perturbators of atopic conditions are irritants, probably reflecting the consistent inflammatory cell hyper‐reactivity due to elevated cyclic AMP‐phosphodiesterase activity. The immunologic reactions are another manifestation of that general cellular dysregulation.
30‐kDa Trypsin‐like Proteases in the Plantar Stratum Corneum
Authors: Chang‐Yi Cui , Takahashi Masae , Tezuka Tadashi 
Published: April 2015

AbstractThe casein digestible proteases in human plantar stratum corneum were determined to be about 75‐kDa, 30‐kDa and 25‐kDa in molecular weight by zymography. The enzymatic activity of the 75‐kDa and 25‐kDa proteases was specifically inhibited by chymostatin, which is an inhibitor of chymotrypsin‐like serine proteases, and the proteases around 30‐kDa were inhibited by leupeptin, a trypsin‐like serine protease inhibitor. The enzymatic activity of all these proteases was inhibited by aprotinin. The 30‐kDa trypsin‐like proteases were heat‐stable; their enzymatic activity still remained even after heating at 100°C for 60 minutes. Their optimal pH was around 9, and the activity was higher in the outer part of the stratum corneum than in the inner part.
Comparison of Personal History with Patch Test Results in Metal Allergy
Authors: Böhm Ingrid , Brody Marlene , Bauer Ralf 
Published: April 2015

AbstractIn order to compare the validity of patient personal history of contact sensitivity to metal alloys with patch test results, 160 patients with hand eczema were patch tested with a standard series according to the ICDRG after a special questionnaire. In 65%, history and patch test results were identical. Seventy‐eight (48.8%) patients thought they would be allergic to metal ions, whereas the patch test revealed a positive result in only 21.3% cases. Positive history but negative test was more frequent in women; in the male group, negative history and positive patch test was the most common finding. Although 82 patients had a negative history, the patch test was positive for contact sensitivity to metal allergens in 12 of them. Both false positive patch tests and false negative histories are possible. Since many factors influence a positive patch test, not only the patient's history but also a synopsis of the anamnesis and patch testing will help to achieve the correct diagnosis of metal contact hypersensitivity.
Cutaneous Disseminated Actinomycosis in a Patient with Acute Lymphocytic Leukemia
Authors: Takeda Hikaru , Mitsuhashi Yoshihiko , Kondo Shigeo 
Published: April 2015

AbstractActinomycosis is an uncommon infectious disease caused predominantly by Actinomyces israelii. The cutaneous disseminated form is usually caused by hematogenous dissemination from a primary extra‐cutaneous lesion. We report here cutaneous disseminated actinomycosis without any detectable extra‐cutaneous lesions in a 42‐year‐old Japanese woman with acute lymphocytic leukemia. Multiple soft nodules developed on her upper and lower extremities. Histopathological examination revealed “sulfur granules”, which are a specific finding for actinomycosis. Cultures from biopsy specimens were not successful. There were no cervicofacial, thoracic, nor abdominal lesions. These findings suggest that cutaneous disseminated actinomycosis in our patient developed primarily in the skin. Although the patient was immunocompromised, antibiotic treatment with minocycline was effective.