bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the current usage of resuscitative endovascular balloon occlusion of the aorta (REBOA) in pediatric trauma patients: a retrospective observational study from the American College of Surgeons–Trauma Quality Improvement Program databases
Authors: Kuo Ling-Wei , Liao Chien-Hung , Cheng Chi-Tung , Fu Chih-Yuan , Liao Chien-An , Wang Chia-Cheng , Huang Jen-Fu , Hsu Chi-Po 
Published: August 2024

BackgroundResuscitative endovascular balloon occlusion of the aorta (REBOA) has been an established life-saving procedure for adult trauma patients, but the evidence for its use in pediatric patients is still under question. The purpose of this study was to examine the outcome of REBOA in pediatric patients.MethodsWe retrospectively analyzed observational cohort data from the American College of Surgeons–Trauma Quality Improvement Program from 2017 to 2019. We analyzed 183 506 trauma patients aged 7–18, and 111 patients were matched by propensity score analysis. Basic demographics, injury severity, trauma type, and clinical outcomes of the patients receiving REBOA and those not receiving REBOA were compared. In the REBOA patients, a subgroup analysis was performed to evaluate the potential influence of age and body weight on the outcomes of REBOA.ResultsAfter the pretreatment factors were balanced for the REBOA and no-REBOA groups, the patients in the REBOA group had more transfused packed red blood cells within the first 4 hours (3250 mL vs. 600 mL, p<0.001), and the mortality rate was higher in the REBOA group, but it did not reach statistical significance (56.8% vs. 36.5%, p=0.067). No significant difference was detected regarding in-hospital complications. In the subgroup analysis of the patients who received REBOA, we discovered no significant difference in mortality and complications between the subgroups when compared by age (>15 years old/≤15 years old) or weight (>58 kg or ≤58 kg).ConclusionsPediatric trauma patients who received REBOA were not significantly associated with an increased risk of mortality when compared with no-REBOA patients with matched basic demographics and pretreatment factors. Younger age and lighter body weight did not seem to influence the outcomes of REBOA regarding survival and complications.Level of evidenceLevel III
Why and how did the COVID pandemic end abruptly?
Authors: Moret Marcelo A. , Phillips James C. 
Published: August 2024

AbstractPhase transition theory, implemented quantitatively by thermodynamic scaling, has explained the evolution of Coronavirus’ extremely high contagiousness caused by a few key mutations from CoV2003 to CoV2019 identified among hundreds, as well as the later 2021 evolution to Omicron caused by 30 mutations. It also showed that the 2022 strain BA.5 with five mutations began a new path. Here we show that the early 2023 strains BKK with one stiffening mutation confirm that path, and the single flexing mutation of a later 2023 variant EG.5 strengthens it further. The few mutations of the new path have greatly reduced pandemic deaths, for mechanical reasons proposed here.
Graphical abstract
Geological factors in the sustainable management of mine water heating, cooling and thermal storage resources in the UK
Authors: Monaghan Alison A. , Adams Charlotte A. , Bell Rachel A. , Lewis Melinda A. , Boon David , González Quirós Andres , Starcher Vanessa , Farr Gareth , Wyatt Lee M. , Todd Fiona , Walker-Verkuil Kyle , MacAllister Donald John , Abesser Corinna , Palumbo-Roe Barbara , Scheidegger Johanna 
Published: August 2024

Re-use of the UK's coal mine water heating, cooling and thermal storage resource is increasing in scale and the number of schemes. The upward trajectory requires 3D planning, regulation and licensing to manage sustainable deployment. We review geological factors controlling thermal and flow processes in the anthropogenically-altered subsurface, critical for resource management with multiple users of the same space. Potential interactions of mine water geothermal schemes with the wider environment are also summarized, leading towards concepts of 3D mine water thermal blocks, protection zones, or management strategies integrating heating, cooling and storage demands.
Factors such as the magnitude, extent and timescale of thermal processes to underpin management approaches are poorly quantified by data measured at-scale under varying pumping rates and thermal loads. We demonstrate early insights of how two infrastructures, the UK Geoenergy Observatory in Glasgow and the Coal Authority's Mine Water Heat Living Lab in Gateshead, can measure and monitor heat-flow processes in real world settings to provide an evidence base. For example, a thermal storage test at Glasgow showed rapid temperature changes in the rock and mine workings at the re-injection borehole and indicated an influence of lithologically-controlled transmissivity and thermal conductivity on temperature dissipation and recovery.
Is It Time to Resist Using RECIST as a Primary Endpoint for Rare Tumor Trials?
Authors: Van Tine Brian A. , Haarberg Sasha 
Published: August 2024

Summary
Epithelioid hemangioendothelioma is an ultra-rare cancer driven by YAP–CAMTA1 fusion. Based on the link of the fusion to the MEK pathway, SARC33 was performed. It is a phase 2 trial examining trametinib that missed its primary objective by RECIST but demonstrated patient-reported outcome benefits in improved pain.
See related article by Schuetze et al., p. 4584
Phase I Study of Simlukafusp Alfa (FAP-IL2v) with or without Atezolizumab in Japanese Patients with Advanced Solid Tumors
Authors: Koyama Takafumi , Yonemori Kan , Shimizu Toshio , Sato Jun , Kondo Shunsuke , Sudo Kazuki , Yoshida Tatsuya , Katsuya Yuki , Imaizumi Tatsuki , Enomoto Masashi , Seki Ryoko , Yamamoto Noboru 
Published: August 2024

Abstract

Purpose:
The aim of the study was to evaluate the safety/tolerability and pharmacokinetics of simlukafusp alfa (FAP-IL2v), an immunocytokine containing an anti-fibroblast activation protein-α (FAP) antibody and an IL2 variant, administered alone or with the PDL1 inhibitor atezolizumab, in Japanese patients with advanced solid tumors.

Patients and Methods:
In this phase 1, open-label, dose-escalation study, patients received i.v. FAP-IL2v at 10 or 15/20 mg alone or 10 mg when combined with i.v. atezolizumab. The primary objectives were identification of dose-limiting toxicities (DLT), recommended dose, and maximum tolerated dose, and evaluation of the safety/tolerability and pharmacokinetics of FAP-IL2v alone and combined with atezolizumab.

Results:
All 11 patients experienced adverse events (AE) during FAP-IL2v treatment. Although most AEs were of mild severity, four treatment-related AEs led to study treatment discontinuation in two patients: one with infusion-related reaction, hypotension, and capillary leak syndrome, and the other with increased aspartate aminotransferase. No AE-related deaths occurred. One DLT (grade 3 hypotension) occurred in a patient receiving FAP-IL2v 15/20 mg alone. The recommended dose and maximum tolerated dose could not be determined. The pharmacokinetics of FAP-IL2v remained similar with or without atezolizumab. The study was terminated early as FAP-IL2v development was discontinued because of portfolio prioritization (not for efficacy/safety reasons).

Conclusions:
This study describes the safety/tolerability of FAP-IL2v 10 mg alone and in combination with atezolizumab in Japanese patients with advanced solid tumors; one DLT (hypotension) occurred with FAP-IL2v 15/20 mg. However, dose escalation of FAP-IL2v was not conducted because of early study termination.

Significance:
This phase I study assessed the safety/tolerability and PK of simlukafusp alfa alone or combined with atezolizumab in Japanese patients with advanced solid tumors. No notable differences in PK were noted with the combination versus simlukafusp alfa alone; however, high-dose simlukafusp alfa treatment was associated with recombinant IL2-related toxicity, despite the drug's FAP targeting and IL2Rβγ-biased IL2 variant design.
Psychosocial Stressors at Work and Atrial Fibrillation Incidence: An 18‐Year Prospective Study
Authors: Tiwa Diffo Edwige , Lavigne‐Robichaud Mathilde , Milot Alain , Brisson Chantal , Gilbert‐Ouimet Mahée , Vézina Michel , Talbot Denis , Trudel Xavier 
Published: August 2024

Background
Psychosocial stressors at work, defined by the job strain and effort–reward imbalance at work (ERI) models, were shown to increase coronary heart disease risk. No previous study has examined the adverse effect of psychosocial stressors at work from both models on atrial fibrillation (AF) incidence. The objective of this study was to examine the separate and combined effect of psychosocial stressors at work from the job strain and ERI models on AF incidence in a prospective cohort study.

Methods and Results
A total of 5926 white‐collar workers (3021 women and 2905 men) free of cardiovascular disease at baseline were followed for an average of 18 years. Job strain (high psychological demands combined with low decision latitude) and ERI were assessed using validated instruments. AF events were identified in medical databases with universal coverage. Hazard ratios (HRs) with 95% CIs were estimated using Cox regression models, controlling for socioeconomic characteristics and lifestyle‐related and clinical risk factors. A total of 186 AF incident events were identified over 18 years. Workers exposed to job strain (HR, 1.83 [95% CI, 1.14–2.92]) and ERI (HR, 1.44 [95% CI, 1.05–1.98]) had a higher risk of AF in fully adjusted models. Combined exposure to job strain and ERI was associated with a 2‐fold AF risk increase (HR, 1.97 [95% CI, 1.26–3.07]).

Conclusions
Psychosocial stressors at work from the job strain and ERI models are associated with an increased risk of AF, separately and in combination. Workplace prevention strategies targeting these psychosocial stressors at work may be effective to reduce the burden associated with AF.
Randomized Trials of Renal Denervation for Uncontrolled Hypertension: An Updated Meta‐Analysis
Authors: Mufarrih Syed Hamza , Qureshi Nada Qaisar , Khan Mohammed Saud , Kazimuddin Mohammed , Secemsky Eric , Bloch Michael J. , Giri Jay , Cohen Debbie , Swaminathan Rajesh V. , Feldman Dmitriy N. , Alaswad Khaldoon , Kirtane Ajay , Kandzari David , Aronow Herbert D. 
Published: August 2024

Background
Despite optimal medical therapy, a significant proportion of patients' blood pressure remains uncontrolled. Catheter‐based renal denervation (RDN) has been proposed as a potential intervention for uncontrolled hypertension. We conducted an updated meta‐analysis to assess the efficacy and safety of RDN in patients with uncontrolled hypertension, with emphasis on the differential effect of RDN in patients on and off antihypertensive medications.

Methods and Results
Online databases were searched to identify randomized clinical trials comparing efficacy and safety of RDN versus control in patients with uncontrolled hypertension. Subgroup analyses were conducted for sham‐controlled trials and studies that used RDN devices that have gained or are currently seeking US Food and Drug Administration approval. Fifteen trials with 2581 patients (RDN, 1723; sham, 858) were included. In patients off antihypertensive medications undergoing RDN, a significant reduction in 24‐hour ambulatory (−3.70 [95% CI, −5.41 to −2.00] mm Hg), office (−4.76 [95% CI, −7.57 to −1.94] mm Hg), and home (−3.28 [95% CI, −5.96 to −0.61] mm Hg) systolic blood pressures was noted. In patients on antihypertensive medications, a significant reduction was observed in 24‐hour ambulatory (−2.23 [95% CI, −3.56 to −0.90] mm Hg), office (−6.39 [95% CI, −11.49 to −1.30]), home (−6.08 [95% CI, −11.54 to −0.61] mm Hg), daytime (−2.62 [95% CI, −4.14 to −1.11]), and nighttime (−2.70 [95% CI, −5.13 to −0.27]) systolic blood pressures, as well as 24‐hour ambulatory (−1.16 [95% CI, −1.96 to −0.35]), office (−3.17 [95% CI, −5.54 to −0.80]), and daytime (−1.47 [95% CI, −2.50 to −0.27]) diastolic blood pressures.

Conclusions
RDN significantly lowers blood pressure in patients with uncontrolled hypertension, in patients off and on antihypertensive medications, with a favorable safety profile. The efficacy of RDN was consistent in sham‐controlled trials and contemporary trials using US Food and Drug Administration–approved devices.
Landscape Analysis for Surrogate Models in the Evolutionary Black-Box Context
Authors: Pitra Zbyněk , Koza Jan , Tumpach Jiří , Holeňa Martin 
Published: August 2024

Abstract
Surrogate modeling has become a valuable technique for black-box optimization tasks with expensive evaluation of the objective function. In this paper, we investigate the relationships between the predictive accuracy of surrogate models, their settings, and features of the black-box function landscape during evolutionary optimization by the covariance matrix adaptation evolution strategy (CMA-ES) state-of-the-art optimizer for expensive continuous black-box tasks. This study aims to establish the foundation for specific rules and automated methods for selecting and tuning surrogate models by exploring relationships between landscape features and model errors, focusing on the behavior of a specific model within each generation in contrast to selecting a specific algorithm at the outset. We perform a feature analysis process, identifying a significant number of non-robust features and clustering similar landscape features, resulting in the selection of 14 features out of 384, varying with input data selection methods. Our analysis explores the error dependencies of four models across 39 settings, utilizing three methods for input data selection, drawn from surrogate-assisted CMA-ES runs on noiseless benchmarks within the comparing continuous optimizers (COCO) framework.
Evaluation of Equatorial Westerly Wind Events in the Pacific Ocean in CMIP6 Models
Authors: Riley Dellaripa Emily M. , DeMott Charlotte , Cui Jingxuan , Maloney Eric D. 
Published: August 2024

Abstract
Westerly wind events (WWEs) are anomalously strong, long-lasting westerlies over the Indian or Pacific Oceans that are capable of forcing oceanic wave modes, which in turn can impact the evolution of coupled ocean–atmosphere phenomena such as El Niño–Southern Oscillation (ENSO). This work examines the fidelity of equatorial WWEs over the Pacific Ocean in 30 CMIP6 historical simulations against observations. WWEs are identified using equatorially averaged zonal wind stress anomaly duration, zonal extent, and intensity criteria. Most simulations correctly place the majority of WWEs over the west Pacific although they are skewed westward and generally occur less frequently compared to observations. Simulated WWEs tend to be weaker than observations for a given duration and zonal extent with several models having shorter durations and zonal extents than observations. Biases in simulated WWEs are associated with biases in Madden–Julian oscillation (MJO) and convectively coupled Rossby wave (CRW) variability. Models that underpredict WWE forcing in the west Pacific also severely underpredict MJO and CRW variance. Further, the multimodel mean shows a smaller fraction of WWEs associated with both the MJO and CRW than observations.
Tropical Cyclone Rainfall Structure and Its Long-Term Trend over the Western North Pacific
Authors: Chen Xu , Guo Yi-Peng , Tan Zhe-Min 
Published: August 2024

Abstract
The tropical cyclone (TC) rainfall structure over the western North Pacific is categorized into four typical types. Clusters I and IV are featured by the southward-shifted and northward-shifted rainfall centers, respectively. Meanwhile, clusters II and III are characterized by the weak and strong maximum rainfall rates near the TC center, respectively. Apart from rainfall, clusters I–IV show diverse features in locations, intensities, and lifetime stages. Both clusters I and III appear over the low-latitude regions. However, TCs in cluster III have the strongest intensity and are in the mature stage of their lifetime, while TCs in cluster I are relatively weaker and in earlier stages. On the contrary, cluster IV has the highest mean latitude positions and strong intensity, mainly in their later lifetime period. Cluster II shows the weakest TC intensity and mainly locates in the subtropics. Diverse TC locations lead to different effects of large-scale circulation on TC rainfall patterns in clusters I–IV. For clusters I and III, abundant moisture provided by the southwest monsoon causes heavy rainfall. In contrast, cluster IV is mainly affected by midlatitude westerly troughs, which is responsible for the northward-shifted rainfall center. Cluster II shows the weakest TC intensity, resulting in a small rainfall rate. Further analysis shows that the changes in the relative frequency contributed 36% of the decreasing trend of basin-mean inner-core rainfall during 1998–2019, and the shift of rainfall pattern from cluster III to cluster I due to the enhanced monsoon plays a central role.
Historical Subsurface Cooling in the Tropical Pacific and Its Dynamics
Authors: Jiang Feng , Seager Richard , Cane Mark A. 
Published: August 2024

Abstract
Understanding how the tropical Pacific responds to rising greenhouse gases in recent decades is of paramount importance given its central role in global climate systems. Extensive research has explored the long-term trends of tropical Pacific sea surface temperatures (SSTs) and the overlying atmosphere, yet the historical change in the upper ocean has received far less attention. Here, we present compelling evidence of a prominent subsurface cooling pattern along the thermocline in the central-to-eastern tropical Pacific since 1958. This subsurface cooling has been argued to be contributing to the observed cooling or lack of warming of the equatorial cold tongue SST. We further demonstrate that different mechanisms are responsible for different parts of the subsurface cooling. In the central-to-eastern equatorial Pacific and the southeastern off-equatorial Pacific, where zonal wind stress strengthens, a pronounced subsurface cooling trend emerges just above the thermocline that is closely tied to increased Ekman pumping. In the eastern equatorial Pacific where zonal wind stress weakens, the westward surface current and eastward Equatorial Undercurrent weaken as well, resulting in reduced vertical current shear and increased ocean stability, which suppresses vertical mixing and leads to local cooling. We conclude that the historical subsurface cooling is primarily linked to dynamical adjustments of ocean currents to tropical surface wind stress changes.
Unraveling Subseasonal Drought Dynamics in India: Insights from NCMRWF Extended Range Prediction System
Authors: Kumar Kondapalli Niranjan , Gupta Ankur , Mohan T. S. , Mishra Akhilesh Kumar , Ashrit Raghavendra , Momin Imranali M. , Mahapatra Debasis K. , Nagarjuna Rao D. , Mitra Ashis K. , Prasad V. S. , Rajeevan M. 
Published: August 2024

Abstract
Drought, a prolonged natural event, profoundly impacts water resources and societies, particularly in agriculturally dependent nations like India. This study focuses on subseasonal droughts during the Indian summer monsoon season using standardized precipitation index (SPI). Analyzing hindcasts from the National Centre for Medium Range Weather Forecasting (NCMRWF) Extended Range Prediction (NERP) system spanning 1993–2015, we assess NERP’s strengths and limitations. NERP replicates climatic patterns well but overestimates rainfall in the Himalayan foothills and the Indo-Gangetic Plain while underestimating it in the core monsoon zone and western coastline. Nonetheless, the NERP system demonstrates its ability to predict subseasonal drought conditions across India. Our research explores the model’s dynamics, emphasizing tropical and extratropical influences. We evaluate the impact of monsoon intraseasonal oscillation (MSIO) and Madden–Julian oscillation (MJO) on drought onset and persistence, noting model performance and discrepancies. While the model consistently identifies MSIO locations, variations in phase propagation affect drought severity in India. Remarkably, NERP excels in predicting MJO phases during droughts. The study underscores the robust response in the near-equatorial Indian Ocean, a crucial factor in subseasonal drought development. Furthermore, we explored upper-level dynamic interactions, demonstrating NERP’s ability to capture subseasonal drought dynamics. For example, unusual westerly winds weaken the tropical easterly jet, and a cyclonic anomaly transports cold air at midlevels and upper levels. These interactions reduce thermal contrast, weakening monsoon flow and favoring drought conditions. Hence, the NERP system demonstrates its skill in assessing prevailing drought conditions and associated teleconnection patterns, enhancing our understanding of subseasonal droughts and their complex triggers.
Interannual Variability and Trend of the Bering Strait Throughflow Gleaned from Satellite Altimeters
Authors: Sangmanee Chalermrat , Clarke Allan J. 
Published: August 2024

Abstract
Beginning with the TOPEX/Poseidon altimetry mission in 1992, along-track satellite sea surface height (SSH) estimates have been taken every 6–7 km at 10-day intervals at a cluster of satellite tracks across the Bering Strait near 66°N where the satellite tracks turn. Year-to-year geostrophic SSH estimates of the Bering Strait flow show that the flow in the warmer months is almost entirely confined to a 50-m-depth channel rather than the whole cross-sectional area and that the peak-to-peak transport change is comparable to the approximate 0.8 Sverdrup mean (Sv; 1 Sv ≡ 106 m3 s−1). Energy flux calculations using the high-resolution SSH across the Bering Strait, as well as an analysis of historical coastal Russian sea levels and wind stress along the Russian Arctic and Bering Sea shelves, suggest that the interannual Bering Strait transport in the warmer water months can be described using wind-forced arrested topographic waves (ATWs) driven by along-shelf wind stress on both the Russian Arctic and Bering Sea shelves. Most of the Bering Strait transport is barotropic and in the 50-m-depth channel, but analysis of SSH and in situ Alaskan coastal sea level shows that interannual transport variations in the narrow baroclinic Alaskan Coastal Current are not negligible. In disagreement with previous transport estimates, the satellite SSH analysis and almost all of the in situ current measurements do not indicate a significant long-term trend in the barotropic Bering Strait northward transport in the warmer water late summer/fall months.

Significance Statement
The shallow, narrow Bering Strait between eastern Siberia and Alaska is a key climate pathway linking the Pacific Ocean and the Bering Sea to the Arctic Ocean. By utilizing nearly three decades of satellite sea surface height, we found that warmer water month volume transport through the Bering Strait in this remote, harsh environment can be monitored by satellite. Analysis suggests that the average warmer month interannual flows are remotely driven by interannual along-shelf winds on the Russian Arctic and Bering Sea shelves and that the warmer month flow has not increased over the last three decades. As the Arctic continues to warm, more ice-free data will only enhance the utility of this remote Bering Strait transport monitoring.