bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treatment goals for moderate to severe psoriasis: An Australian consensus
Authors: Baker Christopher , Mack Alexandra , Cooper Alan , Fischer Gayle , Shumack Stephen , Sidhu Shireen , Soyer Peter , Wu Jason , Chan Jonathan , Nash Peter , Rawlin Morton , Radulski Barbara , Foley Peter 
Published: January 2013

AbstractBackground/ObjectivesThe high incidence of comorbidities in patients with psoriasis, significant impact on quality of life and patients' dissatisfaction with treatment led a European group to develop a consensus position on psoriasis treatment goals. There is an evident need for similar treatment goals in Australia. The aim of this project was to develop Australian treatment goals that reflect the local environment.MethodsA panel of 12 representatives was drawn from across Australia consisting of nine dermatologists and a rheumatologist, a dermatology nurse and a general practitioner (GP)/dermatology trainee. The group met on three occasions between September 2011 and March 2012. The panel undertook a literature review and critically examined available evidence‐based treatment goals. A questionnaire relating to psoriasis assessment and specific treatment outcomes was developed. Following discussion and debate, recommended treatment goals for psoriasis patients in Australia were determined.ResultsThe panel agreed by consensus on recommended psoriasis treatment goals in the Australian environment. There was recognition that in addition to psoriasis area severity index (PASI) assessment, a quality of life assessment was highly relevant in determining psoriasis severity and treatment outcome. Mild psoriasis was defined as PASI ≤ 10 and a dermatology life quality index (DLQI) ≤ 10, with moderate to severe psoriasis defined as PASI > 10 and/or DLQI > 10. The presence of certain definedclinical features would elevate a patient's classification from mild to moderate/severe. The target for treatment was defined as a maintained change in PASI ≥ 75% improvement and DLQI ≤ 5. These largely concurred with the European treatment goals. A flow chart for psoriasis management in Australia based on outcome measures was developed.ConclusionsThere is a need to identify and articulate treatment goals for psoriasis. Assessment of psoriasis severity requires both physical scoring (PASI) and consideration of quality of life measures (DLQI). Identification of treatment goals will guide clinicians in treatment decision‐making, enhance the availability and appropriate use of therapies and increase patient satisfaction with their care.
Proliferative nodules of undifferentiated spindle cells arising in a large congenital melanocytic naevus
Authors: Christou Elizabeth M , Chen Andrew Chih‐Chieh , Sugo Ella , Barbaric Draga , Wargon Orli 
Published: January 2013

AbstractProliferative nodules (PN) are benign lesions that arise in large congenital melanocytic naevi (LCMN). Clinically and histologically they can be difficult to differentiate from malignancies, which are also associated with LCMN. The PN in this case consisted of undifferentiated spindle cells and exhibited unusual histological features including negative stains for melanocytic markers (S100, HMB45 and MelA), negative stain for c‐Kit, high mitotic index and unusual morphology of the lesional cells. As a result, a firm histological classification could not be made, which posed a challenge for the clinical management.
The major allergen of the Parietaria pollen contains an LPS‐binding region with immuno‐modulatory activity
Authors: Bonura A. , Corinti S. , Schiavi E. , Giacomazza D. , Gianguzza F. , Di Felice G. , Colombo P. 
Published: January 2013

AbstractBackgroundThe major allergens in Parietaria pollen, Par j 1 and Par j 2, have been identified as lipid transfer proteins. The family of the Par j 1 allergens is composed of two isoforms, which differ by the presence of a 37 amino acid peptide (Par37) exclusive to the Par j 1.0101 isoform. The goal of this study was to elucidate the biological properties of the Par37 peptide.MethodsIn silico analysis, spectrofluorimetric experiments and in vitro cell culture assays were used to identify the biological properties of Par37. In addition, a mouse model of sensitization was used to study the influence of Par37 in the murine immune response.ResultsIn silico analysis predicted that Par37 displays characteristics of a host defence peptide. Spectrofluorimetric analysis, real‐time PCR and ELISA assays demonstrated that Par37 possesses an LPS‐binding activity influencing cell signalling in vitro. In RAW264.7 cells, LPS‐induced IL‐6 and TNF‐α transcription and translation were inhibited after preincubation with Par37. Consistent with these data, inhibition of IFN‐γ secretion was observed in murine spleen cells and in human PBMC. Finally, mice immunized with the two Par j 1 isoforms differing in the presence or absence of the Par37 peptide showed different immunological behaviours in vivo.ConclusionsThis study demonstrates that the Par j 1.0101 allergen displays LPS‐binding activity due to the presence of a 37 amino acid COOH‐terminal region and that this region is capable of influencing cytokine and antibody responses in vitro and in vivo.
Glutathione‐S‐transferase P1, early exposure to mould in relation to respiratory and allergic health outcomes in children from six birth cohorts. A meta‐analysis
Authors: Tischer C. G. , Gref A. , Standl M. , Bauer M. , Bergström A. , Brauer M. , Carlsten C. , Gehring U. , Granell R. , Henderson J. , Kerkhof M. , MacNutt M. , Melén E. , Wickman M. , Heinrich J. 
Published: January 2013

AbstractBackgroundThere are conflicting study results regarding the association of exposure to visible mould and fungal components in house dust with respiratory and allergic diseases in children. It has been suggested that functional polymorphisms of the GSTP1 gene may influence the risk for allergic disorders through an impaired defence against oxidant injury.MethodsWe examined in six birth cohorts of over 14 000 children whether the association between early exposure to reported mould at home in relation to respiratory and allergic diseases is modified by a single nucleotide polymorphism of the GSTP1 gene.ResultsWe observed a positive association of mould exposure with nasal symptoms (2–10 year) aOR: 1.19 (1.02–11.38). Further, there was a borderline significant increased risk of rhinoconjunctivitis (6–8 year) in children homozygous for the minor allele Val/Val, aOR: 1.25 (0.98–1.60). In stratified analyses, subjects homozygous for the minor allele and exposed to mould at home were at increased risk for early wheezing aOR: 1.34 (1.03–1.75), whereas the major allele may confer susceptibility for later nasal outcomes, (6–8 year) aOR: 1.20 (1.00–1.45) and (2–10 year) aOR: 1.30 (1.04–1.61), respectively. For none of the health outcomes studied, we found gene by environment interactions.ConclusionA genetic influence of the GSTP1 gene cannot be ruled out, but the magnitude of the effect is a matter of further research. In conclusion, the interplay between gene and environments is complex and remains subject of further study.
Foetal umbilical artery Doppler in small preterms: (IQ) Neurocognitive outcome at 5 years of age
Authors: Eger Siw Helen W. , Sommerfelt Kristian , Kiserud Torvid , Markestad Trond 
Published: January 2013

AbstractAimTo investigate whether absent or reversed end‐diastolic flow in the umbilical artery (AREDF) is associated with neonatal mortality, morbidity or long‐term neurocognitive outcome in extremely preterm infants exposed to preeclampsia or intrauterine growth restriction.MethodsPrenatal Doppler data were retrospectively collected for liveborn infants with gestational age (GA) <28 weeks or birth weight (BW) <1000 g, born small for gestational age (SGA‐ BW <5th percentile for GA) or of mothers with preeclampsia at the four largest university hospitals in Norway during 1999–2000. Neonatal mortality and morbidities, cerebral palsy (CP) and IQ at 5 years of age were compared for infants with or without AREDF.ResultsOf 260 infants, 84 were eligible and 71 of them had sufficient Doppler data. Of these, 38 (54%) had AREDF. Of 33 infants born <28 weeks, 7 of 19 (37%) with AREDF and none of 14 without AREDF had severe cerebral haemorrhage (SCH) (p = 0.01). AREDF was not significantly associated with mortality, other NICU morbidities, CP or reduced IQ. For the 38 infants with GA ≥28 weeks, AREDF (19 of 38) was not associated with adverse outcomes.ConclusionAbsent or reversed end‐diastolic flow in the umbilical artery (AREDF) was associated with increased risk of SCH in extremely preterm infants (GA <28 weeks).
Genome‐wide DNA methylation patterns in discordant sib pairs with alcohol dependence
Authors: Zhao Rongrong , Zhang Ruiling , Li Wenqiang , Liao Yanhui , Tang Jinsong , Miao Qin , Hao Wei 
Published: January 2013

AbstractIntroductionAlcohol dependence is a complex disease caused by a confluence of environmental and genetic factors. Epigenetic mechanisms have been shown to play an important role in the pathogenesis of alcohol dependence.MethodsTo determine if alterations in gene‐specific methylation were associated with alcohol dependence, a genome‐wide DNA methylation analysis was performed on peripheral blood mononuclear cells from alcohol‐dependent patients and siblings without alcohol dependence as controls. The Illumina Infinium Human Methylation450 BeadChip was used and gene‐specific methylation of DNA isolated from peripheral blood mononuclear cells was assessed. Genes ALDH1L2, GAD1, DBH and GABRP were selected to validate beadchip results by pyrosequencing.ResultsCompared to normal controls, 865 hypomethylated and 716 hypermethylated CG sites in peripheral blood mononuclear cell DNA in alcohol‐dependent patients were identified. The most hypomethylated CG site is located in the promoter of SSTR4 (somatostatin receptor 4) and the most hypermethylated CG site is GABRP (gamma‐aminobutyric acid A receptor). The results from beadchip analysis were consistent with that of pyrosequencing.DiscussionDNA methylation might be associated with alcohol dependence. Genes SSTR4, ALDH1L2, GAD1, DBH and GABRP may participate in the biological process of alcohol dependence.
Effects of high potassium chloride supplementation on water intake and bodyweight gains in pregnant and lactating mice
Authors: Murai Iori , Shukuin Susumu , Sugimoto Miki , Ikeda Shuntaro , Kume Shin‐ichi 
Published: January 2013

AbstractThirty‐one ICR pregnant mice were assigned to a control or a potassium chloride (KCl) diet group to clarify the effects of KCl supplementation on water intake, bodyweight gains and serum components in pregnant and lactating mice, and 5% KCl was supplemented in KCl diets from 6.5 days post coitus to 1 or 14 days after parturition. Feed intake was not affected by treatment, but supplemental KCl decreased bodyweight gains of lactating mice and their neonatal mice. Water intake and urine volume of KCl supplemented mice were significantly higher than those of control mice during pregnancy and supplemental KCl decreased serum urea N in pregnant mice. Supplemental KCl increased water intake drastically in lactating mice immediately after parturition and increased serum K at 14 days after parturition. Histological alteration using hematoxylin–eosin was not found in the kidney of each mouse at 1 or 14 days after parturition. These results indicate that high KCl supplementation accelerates water intake in lactating mice and prevents bodyweight gains of maternal and neonatal mice during lactation.
Biological rhythms related to metabolism in Japanese Shorthorn cattle under varying environments and management techniques
Authors: Ogino Mizuna , Matsuura Akihiro , Yamazaki Atusi , Irimajiri Mami , Takahashi Hideyuki , Komatsu Tokushi , Kushibiki Shiro , Shingu Hiroyuki , Kasuya Etsuko , Hasegawa Yoshihisa , Hodate Koichi 
Published: January 2013

AbstractPlasma insulin (INS), thyroxin (T4), glucose (GLU), non‐esterified fatty acid (NEFA), blood urea nitrogen (BUN), rectal temperature (RT) and eating behavior were evaluated in Japanese Shorthorn cattle under varying external environments and management techniques. Serial blood collection and assessments of RT and eating behavior were performed over 48 h in the spring, summer, autumn and winter in four female cattle reared under either free‐stall and ad libitum feeding (FA) conditions or tie‐stall and restricted feeding (TR) conditions. Cycle patterns for each parameter were examined using spectral analysis, and correlations between parameters were investigated using cross‐spectral analysis. Rhythms for all parameters, except eating behavior and T4, did not differ significantly among the varied external environments and between management techniques, although seasonal differences in the concentration or value of parameters were observed. An approximate 3‐ or 4‐h rhythm cycle detected in T4, GLU, NEFA, BUN, and RT might be the common metabolic rhythm. Under both conditions, the metabolite levels showed strong correlations with eating behavior. Moreover, GLU positively correlated with INS at lag time of 0 h, as did eating behavior and RT.
A next step in adeno‐associated virus‐mediated gene therapy for neurological diseases: regulation and targeting
Authors: Chtarto Abdelwahed , Bockstael Olivier , Tshibangu Terence , Dewitte Olivier , Levivier Marc , Tenenbaum Liliane 
Published: January 2013

Recombinant adeno‐associated virus (rAAV) vectors mediating long term transgene expression are excellent gene therapy tools for chronic neurological diseases. While rAAV2 was the first serotype tested in the clinics, more efficient vectors derived from the rh10 serotype are currently being evaluated and other serotypes are likely to be tested in the near future. In addition, aside from the currently used stereotaxy‐guided intraparenchymal delivery, new techniques for global brain transduction (by intravenous or intra‐cerebrospinal injections) are very promising.Various strategies for therapeutic gene delivery to the central nervous system have been explored in human clinical trials in the past decade. Canavan disease, a genetic disease caused by an enzymatic deficiency, was the first to be approved. Three gene transfer paradigms for Parkinson's disease have been explored: converting L‐dopa into dopamine through AADC gene delivery in the putamen; synthesizing GABA through GAD gene delivery in the overactive subthalamic nucleus and providing neurotrophic support through neurturin gene delivery in the nigro‐striatal pathway.These pioneer clinical trials demonstrated the safety and tolerability of rAAV delivery in the human brain at moderate doses. Therapeutic effects however, were modest, emphasizing the need for higher doses of the therapeutic transgene product which could be achieved using more efficient vectors or expression cassettes. This will require re‐addressing pharmacological aspects, with attention to which cases require either localized and cell‐type specific expression or efficient brain‐wide transgene expression, and when it is necessary to modulate or terminate the administration of transgene product. The ongoing development of targeted and regulated rAAV vectors is described.
Interleukin‐1β enhances cell migration through AP‐1 and NF‐κB pathway‐dependent FGF2 expression in human corneal endothelial cells
Authors: Lee Jeong Goo , Heur Martin 
Published: January 2013

AbstractBackground informationInterleukin (IL)‐1β is a major pro‐inflammatory cytokine that plays a crucial role in the regulation of inflammation and wound healing in the cornea. Elucidation of IL‐1β signalling may help identify therapeutic targets for corneal wound healing; however, mechanisms such as cell migration, a component of IL‐1β‐induced wound healing response in human corneal endothelial cells (CEC), have not been well characterised.ResultsStimulation of human CEC with IL‐1β activated expression of fibroblast growth factor 2 (FGF2) and resulted in enhanced cell migration. This, in turn, was abolished by treatment with either IL‐1 receptor antagonist or SU‐5402, a pan–fibroblast growth factor signalling inhibitor. Phosphatidyl inositol (PI) 3‐kinase or IL receptor‐associated kinase 1/4 antagonists demonstrated that IL receptor‐associated kinase 1/4 activates PI 3‐kinase, which in turn phosphorylates p38 and inhibitor κB kinase α/β, leading to FGF2 expression through activation of activator protein 1 (AP‐1) and nuclear factor kappa‐light‐chain enhancer of activated B cells (NF‐κB) in human CEC. Treatment of IL‐1β‐stimulated human CEC with either AP‐1 or NF‐κB antagonists decreased FGF2 expression and resulted in reduced IL‐1β‐enhanced cell migration. Co‐treatment of IL‐1β‐stimulated human CEC with both inhibitors completely blocked FGF2 expression and IL‐1β‐enhanced cell migration. Chromatin immunoprecipitation assays demonstrated that AP‐1 and NF‐κB directly bind to the FGF2 promoter following IL‐1β stimulation.ConclusionsThe results show that binding of IL‐1β to its receptor in human CEC leads to parallel activation of AP‐1 and NF‐κB pathways, leading, in turn, to FGF2 expression and enhanced cell migration.
Seasonal Habitat Use of Agoutis (Dasyprocta azarae) is Driven by the Palm Attalea phalerata in Brazilian Pantanal
Authors: Cid Bruno , Oliveira‐Santos Luiz Gustavo R. , Mourão Guilherme 
Published: January 2013

AbstractResource availability can influence animal movement causing changes in home‐range size and arrangement between seasons. We investigated the influence of acuri palm (Attalea phalerata) on the occupancy of agouti Dasyprocta azare during both the dry and rainy seasons, as well as the abandonment probabilities in the transition between seasons in the Brazilian Pantanal. The agoutis occupied a high proportion of the forested areas in the rainy season (0.83), but the occupancy decreased in the dry season (0.39). In the rainy season, occupancy by agoutis was not correlated with acuri palm availability, while in the dry season, it was positively correlated with the palm's availability. The acuri palm availability also drove the agoutis' probability of site abandonment from the rainy to the dry season, with higher abandonment probability in sites with low acuri palm availability. These findings show that this large‐seeded palm can be an important resource for the agoutis' populations during the fruit‐scarcity period. The acuri palm seeds may be particularly important for agoutis using fragmented forests, given that the large‐seeded palms are able to persist even in small fragments, which is untrue for other important resource.
The Role of Affect in the Neurodevelopment of Morality
Authors: Decety Jean , Howard Lauren H. 
Published: January 2013

AbstractHuman social existence is characterized by an intuitive sense of fairness, concern for others, and the observance of cultural norms. This prosocial sensitivity is the foundation for adult morality, emanating from the sophisticated integration of emotional, motivational, and cognitive mechanisms across development. In this article, we discuss how an integrated neurodevelopmental approach helps us understand moral judgment and behavior. We examine data emphasizing the importance of affect in moral development and we suggest that moral cognition is underpinned by specific, although not unique, neural networks. The regions recruited in moral cognition underlie specific states of emotion, along with cognitive and motivational processes, which emerge and interconnect over the course of development to produce adaptive social behavior.
Considerations of Fairness in the Adolescent Brain
Authors: Crone Eveline A. 
Published: January 2013

AbstractAdolescents experience a marked change in their evaluation of fairness, trust, and reciprocity that leads to more altruistic behavior and tendencies that are oriented toward others. In this article, I highlight advances in brain imaging research to focus on how adolescents make social decisions. Using the Ultimatum Game and the Trust Game as examples, I show that adolescents are relatively focused on the self in early adolescence, with impulse control and perspective taking increasing in later adolescence and early adulthood. These changes are accompanied by a shift in the relative contribution of the dorsomedial prefrontal cortex, a region important for self‐referential processing, to the dorsolateral prefrontal cortex and temporal‐parietal junction, regions important for controlling selfish impulses and perspective taking. This shift in balance may tip adolescents toward more self‐oriented choices in early adolescence and allow them to consider consequences for others in later adolescence.
Little Liars: Development of Verbal Deception in Children
Authors: Lee Kang 
Published: January 2013

AbstractLying is common among adults and a more complex issue in children. In this article, I review two decades of empirical evidence about lying in children from the perspective of speech act theory. Children begin to tell lies in the preschool years for anti‐ and prosocial purposes, and their tendency to lie changes as a function of age and the type of lies being told. In addition, children's ability to tell convincing lies improves with age. In the article, I highlight the central roles that children's understanding of mental states and social conventions play in the development of lying. I also identify areas for research to be done to develop a more comprehensive picture of the typical and atypical developmental courses of verbal deception in children.
Developmental Trajectories of Acculturation in Hispanic Adolescents: Associations With Family Functioning and Adolescent Risk Behavior
Authors: Schwartz Seth J. , Des Rosiers Sabrina , Huang Shi , Zamboanga Byron L. , Unger Jennifer B. , Knight George P. , Pantin Hilda , Szapocznik José 
Published: January 2013

This study examined longitudinal acculturation patterns, and their associations with family functioning and adolescent risk behaviors, in Hispanic immigrant families. A sample of 266 Hispanic adolescents (Mage = 13.4) and their primary parents completed measures of acculturation, family functioning, and adolescent conduct problems, substance use, and sexual behavior at five timepoints. Mixture models yielded three trajectory classes apiece for adolescent and parent acculturation. Assimilated adolescents reported the poorest family functioning, but adolescent assimilation negatively predicted adolescent cigarette smoking, sexual activity, and unprotected sex indirectly through family functioning. Follow‐up analyses indicated that discrepancies between adolescent and parent family functioning reports predicted these adolescent outcomes. Results are discussed regarding acculturation trajectories, adolescent risk behavior, and the mediating role of family functioning.
Update on treatment of hereditary angioedema
Authors: Xu Y.‐Y. , Buyantseva L. V. , Agarwal N. S. , Olivieri K. , Zhi Y.‐X. , Craig T. J. 
Published: January 2013

SummaryHereditary angioedema (HAE) is a rare disease characterized by recurrent, self‐limiting episodes of swelling. New research and therapies have recently emerged and are now available; however, many physicians are not aware of the new developments in HAE. To update immunologists and other health care providers on new advances in HAE therapies, a PubMed, OVID and Google literature search were used to develop this manuscript. English language peer‐reviewed angioedema articles were selected. High quality clinical trials were reviewed and summarized. Acute therapy in the past often consisted of symptom relief with narcotics, hydration and fresh frozen plasma (FFP). Androgens and FFP are frequently used despite multiple, significant side‐effects. Newer therapies include C1‐inhibitor – both human plasma derived and recombinant – as well as contact system modulators such as ecallantide and icatibant. These newer products can be used for treatment of acute attacks of HAE, and C1‐inhibitors can also be used for prophylaxis. These disease‐specific therapies have proven to work by placebo‐controlled studies, have minimal adverse effects and can be utilized for the treatment of HAE.