bluuebunny/crossref_metadata_2025_split huggingface dataset:
Complementation of ditransitive verbs in South Asian Englishes: a multifactorial analysis
Authors: Schilk Marco , Mukherjee Joybrato , Nam Christopher , Mukherjee Sach 
Published: May 2013

AbstractThis paper examines parallels and differences between South Asian Englishes and British English with regard to various factors driving the selection of verb-complementation patterns. Focusing on the prototypical ditransitive verb give and its complementation, we use large web-derived corpora and distinguish between two possible response cases, one based on the dative and prepositional construction (i.e. the dative alternation), the other including monotransitive complementation. Our data has been additionally coded for a number of potential driving factors, such as pronominality and discourse accessibility of the participants in the constructions. Applying a model-exploration technique we isolate the main driving factors for the varieties under scrutiny (Indian English, Pakistani English and British English) and analyze their influence on pattern selection based on a multinomial logistic regression formulation. Our findings show that, while there is a large area of overlap between the varieties, Pakistani English is closer to British English with regard to relevant driving factors than Indian English. Furthermore, we reveal interesting parallels between all three varieties in the use of monotransitive complementation.
Identification of Market Power in the Hungarian Dairy Industry: A Plant-Level Analysis
Authors: Perekhozhuk Oleksandr , Hockmann Heinrich , Fertő Imre , Bakucs Lajos Zoltán 
Published: May 2013

Abstract
The objective of this paper is to provide an alternative model which can be used to test for oligopsony market power applying plant-level data. For this purpose, we took into account empirical studies and specific developments in the Hungarian dairy industry and specified a model that provides useful benchmarks for an econometric test of market power. The results of the econometric analysis show that the effects from policy changes in Hungary, as well as from plant specific issues are highly statistically significant, and produce evidence suggesting the exercise of oligopsony market power in the Hungarian dairy industry.
A Quality-Improvement Collaborative Project to Reduce Pressure Ulcers in PICUs
Authors: Visscher Marty , King Alice , Nie Ann Marie , Schaffer Pat , Taylor Teresa , Pruitt David , Giaccone Mary Jo , Ashby Marshall , Keswani Sundeep 
Published: May 2013

BACKGROUND AND OBJECTIVE:Pediatric patients are at risk for developing pressure ulcers (PUs) and associated pain, infection risk, and prolonged hospitalization. Stage III and IV ulcers are serious, reportable events. The objective of this study was to develop and implement a quality-improvement (QI) intervention to reduce PUs by 50% in our ICUs.METHODS:We established a QI collaborative leadership team, measured PU rates during an initial period of rapid-cycle tests of change, developed a QI bundle, and evaluated the PU rates after the QI implementation. The prospective study encompassed 1425 patients over 54 351 patient-days in the PICU and NICU.RESULTS:The PU rate in the PICU was 14.3/1000 patient-days during the QI development and 3.7/1000 patient-days after QI implementation (P &lt; .05), achieving the aim of 50% reduction. The PICU rates of stages I, II, and III conventional and device-related PUs decreased after the QI intervention. The PU rate in the NICU did not change significantly over time but remained at a mean of 0.9/1000 patient-days. In the postimplementation period, 3 points were outside the control limits, primarily due to an increase in PUs associated with pulse oximeters and cannulas.CONCLUSIONS:The collaborative QI model was effective at reducing PUs in the PICU. Pediatric patients, particularly neonates, are at risk for device-related ulcers. Heightened awareness, early detection, and identification of strategies to mitigate device-related injury are necessary to further reduce PU rates.
Safety and Utilization of Influenza Immunization in Children With Inflammatory Bowel Disease
Authors: Benchimol Eric I. , Hawken Steven , Kwong Jeffrey C. , Wilson Kumanan 
Published: May 2013

OBJECTIVE:
Influenza immunization is recommended for children with IBD, however safety concerns may limit uptake. This study assessed whether immunization was associated with adverse events in IBD patients using a population-based database of children with IBD.

METHODS:
All children &lt;19 years diagnosed with IBD in Ontario, Canada between 1999–2009 were identified using health administrative data, and matched to non-IBD controls. Self-controlled case series (SCCS) analyses determined health services event rates (outpatient visits, hospitalizations and emergency visits) in any 2-week risk period to 180 days post-immunization compared to a no-risk control period. Relative incidence (RI) was calculated for overall and IBD-related events and rates were compared between IBD cases and controls using relative incidence ratios (RIR).

RESULTS:
A total of 4916 IBD patients were matched to 21 686 controls. IBD patients were more likely to have received immunization than controls (25.3% vs 13.2%, P &lt; .001). No increased event rates existed in IBD cases during risk periods (pooled RI 0.95, 95% CI 0.84–1.07), including hospitalizations and emergency visits. There was a slightly higher event rate in IBD cases versus controls for days 3–14 (RIR 1.60, 95% CI 1.05–2.44, P = .03). IBD-related visit rates were lower in risk periods compared to control period (pooled RI 0.81, 95% CI 0.68–0.96).

CONCLUSIONS:
There was no increase in health services use in the post-vaccine risk period in IBD patients, and there was evidence for a protective effect of influenza immunization against IBD-related health services use. Influenza immunization is safe in children with IBD and should be encouraged to improve poor coverage rates.
Honey Pacifier Use Among an Indigent Pediatric Population
Authors: Benjamins Laura J. , Gourishankar Anand , Yataco-Marquez Vanessa , Cardona Elizabeth Hernandez , de Ybarrondo Lisa 
Published: May 2013

BACKGROUND:
Use of honey pacifiers by infants presenting to a pediatric clinic at a county hospital in Houston, Texas, was observed by several of our staff members. Although we could not find any published studies linking the use of honey pacifiers to infant botulism, we also could not find any studies assessing the prevalence of honey pacifier use in general.

METHODS:
We conducted a cross-sectional, descriptive study using a novel survey that had 19 items. The survey was administered to the parents of children up to age 12 months presenting to a county hospital pediatric clinic for well-child care in Houston, Texas, from February 2010 to April 2011.

RESULTS:
There were 397 respondents. Approximately 11% of the respondents reported using honey pacifiers with their infant children. Reasons for use included tradition, infant preference, and perceived health benefits (eg, helps with constipation or colic). Approximately 20% of the honey pacifier users and 23% of the entire group reported knowledge of honey potentially causing an illness in children &lt;12 months of age. Nearly 40% of all respondents also reported using herbal or folk remedies.

CONCLUSIONS:
Honey pacifier use was relatively common among this population, seen in ∼1 out of 10 respondents. A majority of the mothers surveyed (∼80%) were unaware of the potential dangers of giving honey to infants under age 12 months. Herbal medicine use was also common.
Pediatric Hydrocarbon-Related Injuries in the United States: 2000–2009
Authors: Jolliff Heath A. , Fletcher Erica , Roberts Kristin J. , Baker S. David , McKenzie Lara B. 
Published: May 2013

OBJECTIVE:
To generate national estimates of hydrocarbon-related exposures occurring in children ≤5 years of age who were treated in US emergency departments or called a regional poison control center.

METHODS:
This retrospective review compared hydrocarbon-related injuries that occurred from January 1, 2000, through December 31, 2009, that were reported to the National Poison Data System and the National Electronic Injury Surveillance System for children ≤5 years of age.

RESULTS:
From 2000 through 2009, the National Poison Data System reported 65 756 actual calls to regional poison centers, and the National Electronic Injury Surveillance System reported an estimated 40 158 emergency department visits for hydrocarbon-related injuries. Individuals involved were predominantly male and 1 to 2 years of age. Ingestion was the most common mechanism of injury, and most injuries did not result in hospitalization. The rate of emergency department visits and calls to poison centers decreased significantly (P &lt; .0001) over the 10-year study period. Exposures to hydrocarbons demonstrated seasonal variation, with more occurrences in the summer months.

CONCLUSIONS:
The comparison of the two data sets illustrates a similar trend in hydrocarbon-related injuries in children. Although cases have declined, most likely due to existing prevention efforts, hydrocarbons are still a large source of preventable exposure and injury in children.
Increased Nucleic Acid Receptor Expression in Chronic Periodontitis
Authors: Sahingur S. Esra , Xia Xia‐Juan , Voth Stephanie C. , Yeudall W. Andrew , Gunsolley John C. 
Published: May 2013

Background: Nucleic acid sensing has emerged as one of the important components of the immune system triggering inflammation. The aim of this study is to determine the expression of bacterial DNA sensors, including Toll‐like receptor 9 (TLR‐9), DNA‐dependent activator of interferon‐regulatory factors (DAI), and absent in melanoma 2 (AIM2) in chronic periodontitis (CP versus healthy) (H) tissues.Methods: Thirty‐five CP and 27 H gingival biopsies were included. Real‐time quantitative polymerase chain reaction was performed to determine mRNA levels of AIM2, DAI, and TLRs (TLR‐1 through TLR‐9). The difference in gene expression for each sensor between CP and H tissues was calculated using analysis of covariance. The Spearman test was used to determine correlations among innate receptors. The expression of TLR‐9, AIM2, and DAI in gingival tissues was further confirmed using immunohistochemistry.Results: The present results reveal statistically significant upregulation of TLR‐9 (P <0.006), DAI (P <0.001), and TLR‐8 (P <0.01) in CP tissues compared to H sites. Although mRNA expression was not changed significantly between groups for other receptors, the present results reveal significant correlations between receptors (P <0.05), suggesting that cooperation between multiple components of the host immune system may influence the overall response. Immunohistochemistry further confirmed expression of TLR‐9, AIM2, and DAI in gingival tissues.Conclusions: This study highlights a possible role for nucleic acid receptors in periodontal inflammation. Future investigations will determine whether cytoplasmic receptors and their ligands can be targeted to improve clinical outcomes in periodontitis.
Combining Salivary Pathogen and Serum Antibody Levels Improves Their Diagnostic Ability in Detection of Periodontitis
Authors: Liljestrand John M. , Gursoy Ulvi K. , Hyvärinen Kati , Sorsa Timo , Suominen Anna L. , Könönen Eija , Pussinen Pirkko J. 
Published: May 2013

Background: Initiation and progression of periodontitis correlates with increased quantities of periodontitis‐associated bacteria in periodontal biofilms. In the present study, the aim is to measure Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis amounts in saliva and their antibody (immunoglobulin [Ig]A and IgG) levels in serum and evaluate their diagnostic abilities, together or alone, in chronic periodontitis.Methods: The study population comprised 230 Finnish dentate adults: 84 with generalized chronic periodontitis (GCP), 65 with localized chronic periodontitis (LCP), and 81 controls without periodontitis. General and oral health information was obtained by questionnaires, interviews, and clinical and radiographic examinations. Salivary and serum samples were analyzed by quantitative single copy gene–based real‐time polymerase chain reaction and multiserotype enzyme‐linked immunosorbent assay, respectively.Results: Pathogen carriers suffered mostly from GCP and seldom from LCP. A. actinomycetemcomitans and P. gingivalis quantities in saliva were strongly associated with corresponding serum IgA and IgG values (P <0.001) and with severity of disease (P <0.001). P. gingivalis exhibited more straightforward associations among salivary bacterial burdens, corresponding antibody formation, and periodontitis severity than A. actinomycetemcomitans. The combination of information on age, sex, smoking, and P. gingivalis results provided an area under the curve of 0.817 (95% confidence interval 0.76 to 0.87, P <0.001) for GCP.Conclusion: The combination of saliva P. gingivalis quantity with pathogen‐specific host response may be used to diagnose periodontitis with high accuracy.
Les Cinq-Cents à Érythrie
Authors: Knoepfler Denis 
Published: May 2013

Un traité d'alliance entre Athènes et Érétrie, datant de 341 av. J.-C. (IG, II*, 230), fait mention d'un corps de 500 membres qui, sur la base d'une restitution toujours adoptée jusqu'ici, serait le Conseil d'Érétrie. Mais ce supplément, problématique à plus d'un titre, se heurte à un obstacle matériel insurmontable (à cause du stoichêdon) dès le moment où l'on s'avise qu'à la même ligne il faut de toute nécessité substituer τὴν συμ[μαχίαν] à [τὴν συν[θήκην]. D'autres modifications se révèlent alors indispensables. En fin de compte, il apparaît que les Cinq-Cents doivent être identifiés aux hippeis mentionnés dans un second fragment de la même inscription. On écrira donc [τους ἱππέας] (au lieu de [τήν τε βουλὴν]) τοὺς πεντακοσίους. Les cavaliers d'Érétrie, qui formaient un contingent de 600 hommes à l'époque archaïque, ont joué un rôle considérable dans l'histoire de cette cité. S'ils n'étaient plus que 500 au ive s. (à raison de 100 par chôros, puisque la subdivision en cinq « districts » semble aujourd'hui établie), ils représentaient toujours une force politique importante, de tendance évidemment oligarchique. D'où l'obligation qui leur fut faite, après l'expulsion du tyran Kleitarchos, de s'engager tous à respecter l'alliance conclue avec la démocratie athénienne.
Une réédition complète de ce traité est donnée en appendice.
Development and characterization of EST‐SSR markers in the Chinese medicinal plant Callerya speciosa (Fabaceae)
Authors: Li Li , Li Zhiying , Li Kelie , Huang Bilan , Xu Li 
Published: May 2013

• Premise of the study: The first microsatellite primers were developed for Callerya speciosa, an important traditional medicinal plant with island‐mainland distributions in China, to further investigate its genetic variability and population structure.• Methods and Results: The microsatellite‐containing sequences were selected from a cDNA library of C. speciosa. In total, 58 primer pairs were designed, and 25 of the corresponding loci showed clear amplification. Polymorphisms were assessed in two different natural populations. The mean number of alleles per locus ranged from two to nine. Observed and expected heterozygosity per loci ranged from 0.067 to 0.938 and 0.064 to 0.836, respectively. One out of 25 loci showed departure from Hardy–Weinberg equilibrium expectations in both populations, and three pairs of loci showed significant linkage disequilibrium after Bonferroni correction.• Conclusions: These microsatellite markers will be useful tools for genetic and conservation studies and to understand the evolutionary processes in Callerya species.
Esquisse d'un guide des perplexes : problèmes de définition et de classification des adverbes de degré en français
Authors: Gaatone David 
Published: May 2013

Les notions de quantité et d’ intensité sont très présentes dans le lexique du français. Mais elles restent trop intuitives. On essaie ici de les circonscrire plus rigoureusement, en notant tout d’abord qu’il s’agit des deux faces d’une même notion, le degré , dont la définition inclut les termes mesure ou dimension. En effet, de nombreux adverbes désignent tant la quantité que l’intensité (tellement) et des adverbes différents, les uns visant plutôt la quantité (beaucoup) , les autres plutôt l’intensité (très) , fonctionnent comme variantes libres ou contextuelles. On distinguera aussi les purs marqueurs de degré (combien) de ceux où le degré est associé à d’autres sèmes (loin, longtemps) . Par ailleurs, ces adverbes ne forment pas une classe sémantique ou syntaxique homogène. Certains sont des marqueurs de mesure de degré (beaucoup) , d’autres, de conformité, d’égalité ou d’emphase de degré (assez, trop, si) . D’autres propriétés, telles que l’orientation argumentative (peu, un peu), la définitude (trois, beaucoup), les niveaux (faible, moyen, élevé : peu, pas mal, beaucoup) , la nombrabilité (peu, un peu) , découpent l’inventaire en diverses sous-classes.
La gestion d’un lagon en mutation : acteurs, enjeux et recherche-action en Nouvelle-Calédonie (Pacifique sud)
Authors: Léopold Marc , Sourisseau Jean-Michel , Cornuet Nathaniel , David Carine , Bonmarchand Arnaud , Meur Pierre-Yves Le , Lasseigne Laetitia , Poncet Estelle , Toussaint Marie , Fontenelle Guy , Beuret Jean-Eudes , Guillemot Nicolas 
Published: May 2013

Cet article synthétise les résultats d’un programme de recherche interdisciplinaire effectué sur la côte nord-ouest de la province Nord de la Nouvelle-Calédonie (Pacifique sud) de 2008 à 2011. Cette région fait face aux rapides changements urbains et économiques induits par la création d’un important complexe métallurgique. Ce projet industriel, porteur de développement économique, est aussi un projet politique emblématique du processus original de décolonisation négociée dans lequel la Nouvelle-Calédonie est engagée. Une démarche scientifique adaptative a été mise en place pour améliorer la connaissance de l’écosociosystème côtier et mieux gérer les usages littoraux, et les petites pêcheries en particulier. Cette démarche combinait trois approches complémentaires : recherche-action (s’appuyant sur les points de vue et les logiques des parties prenantes locales), interdisciplinarité (sciences biologiques, sociales et juridiques) et partenariat entre plusieurs institutions de recherche et de développement. Les résultats montrent que les principaux défis de gestion des usages littoraux sont fortement imbriqués et renvoient à des questions environnementales, sociales, culturelles aussi bien qu’économiques et politiques. Toutes les conditions pour la réussite d’une gestion participative ne sont pas actuellement réunies à l’échelle de la zone d’étude. Cependant, notre étude ouvre des pistes pour la promotion d’initiatives de gouvernance partagée, en se fondant sur des dynamiques locales existantes ou émergentes pouvant être élargies à d’autres échelles. Des orientations de politiques publiques sont aussi suggérées, incluant la promotion d’approches territoriales pour le développement local.
Developmental Expression of IL-12Rβ2 on Murine Naive Neonatal T Cells Counters the Upregulation of IL-13Rα1 on Primary Th1 Cells and Balances Immunity in the Newborn
Authors: Hoeman Christine M. , Dhakal Mermagya , Zaghouani Adam A. , Cascio Jason A. , Wan Xiaoxiao , Khairallah Marie-Therese , Chen Weirong , Zaghouani Habib 
Published: May 2013

Abstract
Upon exposure to Ag on the day of birth, neonatal mice mount balanced primary Th1 and Th2 responses, with the former displaying upregulated IL-13Rα1 expression. This chain associates with IL-4Rα to form a heteroreceptor (IL-4Rα/IL-13Rα1) that marks the Th1 cells for death by IL-4 produced by Th2 cells during rechallenge with Ag, hence the Th2 bias of murine neonatal immunity. The upregulation of IL-13Rα1 on neonatal Th1 cells was due to the paucity of IL-12 in the neonatal environment. In this study, we show that by day 8 after birth, naive splenic T cells are no longer susceptible to IL-13Rα1 upregulation even when exposed to Ag within the neonatal environment. Furthermore, during the 8-d lapse, the naive splenic T cells spontaneously and progressively upregulate the IL-12Rβ2 chain, perhaps due to colonization by commensals, which induce production of IL-12 by cells of the innate immune system such as dendritic cells. In fact, mature T cells from the thymus, a sterile environment not accessible to microbes, did not upregulate IL-12Rβ2 and were unable to counter IL-13Rα1 upregulation. Finally, the 8-d naive T cells were able to differentiate into Th1 cells even independently of IL-12 but required the cytokine to counter upregulation of IL-13Rα1. Thus, in neonatal mice, IL-12, which accumulates in the environment progressively, uses IL-12Rβ2 to counter IL-13Rα1 expression in addition to promoting Th1 differentiation.
miR-142-3p Is Involved in CD25+ CD4 T Cell Proliferation by Targeting the Expression of Glycoprotein A Repetitions Predominant
Authors: Zhou Qihui , Haupt Sonja , Prots Iryna , Thümmler Katja , Kremmer Elisabeth , Lipsky Peter E. , Schulze-Koops Hendrik , Skapenko Alla 
Published: May 2013

Abstract
Because of the numerous targets of microRNAs (miRNAs), functional dissection of specific miRNA/mRNA interactions is important to understand the complex miRNA regulatory mechanisms. Glycoprotein A repetitions predominant (GARP) is specifically expressed on regulatory CD25+ CD4 T cells upon their activation. GARP has a long 3′ untranslated region containing five highly conserved regions suggesting miRNA regulation of its expression. Although GARP is physiologically expressed on a cell subset characterized by stringent control of proliferation, amplification of the GARP gene has been found in many tumors characterized by uncontrolled proliferation. In this study, we investigated in detail miRNA regulation of GARP expression, in particular by miR-142-3p, and dissected the functional outcome of miR-142-3p/GARP mRNA interaction. We demonstrate that miR-142-3p binds directly to the 3′ untranslated region of GARP and represses GARP protein expression by Argonaute 2–associated degradation of GARP mRNA. Functionally, miR-142-3p–mediated regulation of GARP is involved in the expansion of CD25+ CD4 T cells in response to stimulation. The data indicate that miR-142-3p regulates GARP expression on CD25+ CD4 T cells and, as a result, their expansion in response to activation. Our data provide novel insight into the molecular mechanisms controlling regulatory T cell expansion. They may also have implications for understanding tumor cell biology.