bluuebunny/crossref_metadata_2025_split huggingface dataset:
Importance of Endogenous Atrial and Brain Natriuretic Peptides in Murine Embryonic Vascular and Organ Development
Authors: Tokudome Takeshi , Kishimoto Ichiro , Shindo Takayuki , Kawakami Hayato , Koyama Teruhide , Otani Kentaro , Nishimura Hirohito , Miyazato Mikiya , Kohno Masakazu , Nakao Kazuwa , Kangawa Kenji 
Published: October 2015

Abstract
Atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP) bind to the receptor guanylyl cyclase (GC)-A, leading to diuresis, natriuresis, and blood vessel dilation. In addition, ANP and BNP have various angiogenic properties in ischemic tissue. When breeding mice devoid of GC-A, we noted significant skewing of the Mendelian ratio in the offspring, suggesting embryonic lethality due to knockout of GC-A. Consequently, we here investigated the roles of endogenous ANP and BNP in embryonic neovascularization and organ morphogenesis. Embryos resulting from GC-A−/− × GC-A+/− crosses developed hydrops fetalis (HF) beginning at embryonic day (E)14.5. All embryos with HF had the genotype GC-A−/−. At E17.5, 33.3% (12 of 36) of GC-A−/− embryos had HF, and all GC-A−/− embryos with HF were dead. Beginning at E16.0, HF-GC-A−/− embryos demonstrated poorly developed superficial vascular vessels and sc hemorrhage, the fetal side of the placenta appeared ischemic, and vitelline vessels on the yolk sac were poorly developed. Furthermore, HF-GC-A−/− embryos also showed abnormal constriction of umbilical cord vascular vessels, few cardiac trabeculae and a thin compact zone, hepatic hemorrhage, and poor bone development. Electron microscopy of E16.5 HF-GC-A−/− embryos revealed severe vacuolar degeneration in endothelial cells, and the expected 3-layer structure of the smooth muscle wall of the umbilical artery was indistinct. These data demonstrate the importance of the endogenous ANP/BNP-GC-A system not only in the neovascularization of ischemic tissues but also in embryonic vascular development and organ morphogenesis.
β1-Adrenergic and M2 Muscarinic Autoantibodies and Thyroid Hormone Facilitate Induction of Atrial Fibrillation in Male Rabbits
Authors: Li Hongliang , Murphy Taylor , Zhang Ling , Huang Bing , Veitla Vineet , Scherlag Benjamin J. , Kem David C. , Yu Xichun 
Published: October 2015

Abstract
Activating autoantibodies to the β1-adrenergic and M2 muscarinic receptors are present in a very high percentage of patients with Graves' disease and atrial fibrillation (AF). The objective of this study was to develop a reproducible animal model and thereby to examine the impact of these endocrine-like autoantibodies alone and with thyroid hormone on induction of thyroid-associated atrial tachyarrhythmias. Five New Zealand white rabbits were coimmunized with peptides from the second extracellular loops of the β1-adrenergic and M2 muscarinic receptors to produce both sympathomimetic and parasympathomimetic antibodies. A catheter-based electrophysiological study was performed on anesthetized rabbits before and after immunization and subsequent treatment with thyroid hormone. Antibody expression facilitated the induction of sustained sinus, junctional and atrial tachycardias, but not AF. Addition of excessive thyroid hormone resulted in induced sustained AF in all animals. AF induction was blocked acutely by the neutralization of these antibodies with immunogenic peptides despite continued hyperthyroidism. The measured atrial effective refractory period as one parameter of AF propensity shortened significantly after immunization and was acutely reversed by peptide neutralization. No further decrease in the effective refractory period was observed after the addition of thyroid hormone, suggesting other cardiac effects of thyroid hormone may contribute to its role in AF induction. This study demonstrates autonomic autoantibodies and thyroid hormone potentiate the vulnerability of the heart to AF, which can be reversed by decoy peptide therapy. These data help fulfill Witebsky's postulates for an increased autoimmune/endocrine basis for Graves' hyperthyroidism and AF.
X-linked Christianson syndrome: heterozygous female Slc9a6 knockout mice develop mosaic neuropathological changes and related behavioral abnormalities
Authors: Sikora Jakub , Leddy Jennifer , Gulinello Maria , Walkley Steven U. 
Published: October 2015

ABSTRACT
Christianson syndrome (CS) is an X-linked neurodevelopmental and neurological disorder characterized in males by core symptoms that include non-verbal status, intellectual disability, epilepsy, truncal ataxia, postnatal microcephaly and hyperkinesis. CS is caused by mutations in the SLC9A6 gene, which encodes a multipass transmembrane sodium (potassium)-hydrogen exchanger 6 (NHE6) protein, functional in early recycling endosomes. The extent and variability of the CS phenotype in female heterozygotes, who presumably express the wild-type and mutant SLC9A6 alleles mosaically as a result of X-chromosome inactivation (XCI), have not yet been systematically characterized. Slc9a6 knockout mice (Slc9a6 KO) were generated by insertion of the bacterial lacZ/β-galactosidase (β-Gal) reporter into exon 6 of the X-linked gene. Mutant Slc9a6 KO male mice have been shown to develop late endosomal/lysosomal dysfunction associated with glycolipid accumulation in selected neuronal populations and patterned degeneration of Purkinje cells (PCs). In heterozygous female Slc9a6 KO mice, β-Gal serves as a transcriptional/XCI reporter and thus facilitates testing of effects of mosaic expression of the mutant allele on penetrance of the abnormal phenotype. Using β-Gal, we demonstrated mosaic expression of the mutant Slc9a6 allele and mosaically distributed lysosomal glycolipid accumulation and PC pathology in the brains of heterozygous Slc9a6 KO female mice. At the behavioral level, we showed that heterozygous female mice suffer from visuospatial memory and motor coordination deficits similar to but less severe than those observed in X-chromosome hemizygous mutant males. Our studies in heterozygous Slc9a6 KO female mice provide important clues for understanding the likely phenotypic range of Christianson syndrome among females heterozygous for SLC9A6 mutations and might improve diagnostic practice and genetic counseling by helping to characterize this presumably underappreciated patient/carrier group.
Is It Possible to Get out of the Economic Crisis in the Coming Years?
Authors: Басовский  , Basovskiy Leonid , Басовская  , Basovskaya Elena 
Published: October 2015

The paper is aimed to forecast how the crisis in the Russian economy is likely
to evolve. The construction of econometric models of Russia’s economic
dynamics for the period of 2000 to 2015 allows to predict, that in 2015-2019 the
deep economic crisis is to be expected. During the crisis period the overall
decline in production can reach 20%. The greatest decline in production is likely
to occur in 2016-2017. In 2019-2020 stabilization or transition to growth of
production can follow. Present crisis developments are by about 80% due to
unfavorable institutional environment, being the result of the laws adopted.
Thus the transition to economic growth even in 2019-2020 is quite questionable.
As the authors argue, to overcome the crisis developments in the economy, it is
needed to pursue more effective policy of building institutions, which would
boost economic growth and economic development, as well as policies, aimed
at encouraging entrepreneurship development, bringing in investments and
expanding domestic demand.
Mechanisms for Economic Regulation of Innovative Activities
Authors: Кальянов  , Kalyanov Aleksandr , Лунёва  , Luneva Anna 
Published: October 2015

The paper considers the term «innovation» as a novelty or newly introduced
development, which results in positive economic and social effects to the
enterprise concerned. The government plays an important role in regulating
innovative processes and acts as a guarantor for private investors. Reviewed
are the direct and indirect methods of government regulation in the sphere of
innovative activities. The types of tax remissions for entrepreneurs are reviewed
and measures, concerning the public risk (venture) enterprise, are outlined.
Technical Debt and the Reliability of Enterprise Software Systems: A Competing Risks Analysis
Authors: Ramasubbu Narayan , Kemerer Chris F. 
Published: October 2015

Enterprise software systems are required to be highly reliable because they are central to the business operations of most firms. However, configuring and maintaining these systems can be highly complex, making it challenging to achieve high reliability. Resource-constrained software teams facing business pressures can be tempted to take design shortcuts in order to deliver business functionality more quickly. These design shortcuts and other maintenance activities contribute to the accumulation of technical debt, that is, a buildup of software maintenance obligations that need to be addressed in the future. We model and empirically analyze the impact of technical debt on system reliability by utilizing a longitudinal data set spanning the 10-year life cycle of a commercial enterprise system deployed at 48 different client firms. We use a competing risks analysis approach to discern the interdependency between client and vendor maintenance activities. This allows us to assess the effect of both problematic client modifications (client errors) and software errors present in the vendor-supplied platform (vendor errors) on system failures. We also examine the relative effects of modular and architectural maintenance activities undertaken by clients in order to analyze the dynamics of technical debt reduction. The results of our analysis first establish that technical debt decreases the reliability of enterprise systems. Second, modular maintenance targeted to reduce technical debt was approximately 53% more effective than architectural maintenance in reducing the probability of a system failure due to client errors, but it had the side effect of increasing the chance of a system failure due to vendor errors by approximately 83% more than did architectural maintenance activities. Using our empirical results we illustrate how firms could evaluate their business risk exposure due to technical debt accumulation in their enterprise systems, and we assess the estimated net effects, both positive and negative, of a range of software maintenance practices. Finally, we discuss implications for research in measuring and managing technical debt in enterprise systems.This paper was accepted by Chris Forman, information systems.
Inventory Pooling Under Heavy-Tailed Demand
Authors: Bimpikis Kostas , Markakis Mihalis G. 
Published: October 2015

Risk pooling has been studied extensively in the operations management literature as the basic driver behind strategies such as transshipment, manufacturing flexibility, component commonality, and drop shipping. This paper explores the benefit of risk pooling in the context of inventory management using the canonical model first studied in Eppen [Eppen GD (1979) Effects of centralization on expected costs in a multi-location newsboy problem. Management Sci. 25(5):498–501]. Specifically, we consider a single-period, multilocation newsvendor model, where n different locations face independent and identically distributed demands and linear holding and backorder costs. We show that Eppen’s celebrated result, i.e., that the expected cost savings from centralized inventory management scale with the square root of the number of locations, depends critically on the “light-tailed” nature of the demand uncertainty. In particular, we establish that the benefit from pooling relative to the decentralized case, in terms of both expected cost and safety stock, is equal to n(α–1)/α for a class of heavy-tailed demand distributions (stable distributions), whose power-law asymptotic decay rate is determined by the parameter α ∈ (1, 2). Thus, the benefit from pooling under heavy-tailed demand uncertainty can be significantly lower than [Formula: see text], which is predicted for normally distributed demands. We discuss the implications of this result on the performance of periodic-review policies in multiperiod inventory management, as well as for the profits associated with drop-shipping fulfillment strategies. Corroborated by an extensive simulation analysis with heavy-tailed distributions that arise frequently in practice, such as power law and log normal, our findings highlight the importance of taking into account the shape of the tail of demand uncertainty when considering a risk pooling initiative. This paper was accepted by Serguei Netessine, operations management.
Mutual Forbearance and Competition Among Security Analysts
Authors: Baum Joel A. C. , Bowers Anne , Mohanram Partha 
Published: October 2015

Research in industrial organization and strategic management has shown that rivals competing with each other in multiple markets are more willing to show each other mutual forbearance, i.e., compete less aggressively, within their spheres of influence, i.e., the markets in which each firm dominates. Sell-side equity analysts typically cover multiple stocks in common with their rivals. We examine the impact of this “multipoint contact” for mutual forbearance on two key dimensions of competition among security analysts: forecast accuracy and information leadership (issuing earnings forecasts or stock recommendations that influence rival analysts). We find that multipoint contact is associated with analysts exerting greater information leadership on stocks within their own spheres of influence. We also find greater forbearance related to information leadership under Regulation Fair Disclosure (Reg FD). In contrast, multipoint contact was not associated with greater forecast accuracy on stocks within analysts’ spheres of influence, either before or under Reg FD. Our analysis is among the first to consider mechanisms of competition among securities analysts and also adds to the literature on Reg FD by demonstrating that the increased workload imposed on analysts after Reg FD fostered mutual forbearance as a response. This paper was accepted by Mary Barth, accounting.
Corporate Science, Innovation, and Firm Value
Authors: Simeth Markus , Cincera Michele 
Published: October 2015

Many firms actively disclose research findings in scientific peer-reviewed journals. The literature highlights several potential benefits of such scientific boundary-spanning activities, including privileged access to academic information networks. However, scientific disclosure may lead to unintended knowledge spillovers. It remains unclear whether active engagement in science leads to higher returns. This paper investigates the impact of scientific activities on the firm’s market value, using accounting data for U.S. firms and matched patent and scientific publication data. We find evidence for the positive impact of scientific publications on a firm’s market value beyond the effects of research and development, patent stocks, and patent quality, and also document heterogeneity with respect to this impact between different industrial sectors. This paper was accepted by David Hsu, entrepreneurship and innovation.
Meta_Body: Uma Investigação Baseada na Prática Artística
Authors: Sousa Catarina Carneiro de 
Published: October 2015

Meta_Body é um projeto artístico participatório de partilha construção de avatares, em desenvolvimento em ambiente virtual colaborativo. Trata-se de um projeto de investigação-ação orientado e baseado na prática artística, uma vez que a abordagem teórica informa, mas também é informada pela praxis, e cujos principais eixos estruturantes da investigação são a constituição de uma corporeidade virtual e o processo criativo partilhado. DOI: http://dx.doi.org/10.14195/2182-8830_3-1_12
Sobre o Conhecimento que a Arte É
Authors: Melo e Castro E.M. de 
Published: October 2015

Este artigo tem por fim repensar a teoria da arte contemporânea à luz de conceitos científicos, estabelecendo uma provável correspondência estrutural entre invenção artística e invenção científica. Mas também alertar para a indispensabilidade de um adequado pensamento teórico sobre a arte, num mundo pré-catastrófico. DOI: http://dx.doi.org/10.14195/2182-8830_3-1_14
Dígitos a Contrapelo ou da Materialidade do Erro na Cultura Digital
Authors: Neves Nuno Miguel 
Published: October 2015

Recensão crítica de Peter Krapp, Noise Channels: Glitch and Error in Digital Culture. Minneapolis, University of Minnesota Press, 2011, 162 pp. ISBN 978-0-8166-7625-5
DOI: http://dx.doi.org/10.14195/2182-8830_3-1_19
Interlíngua: Miscigenação Linguística e Ficção Poética
Authors: Matuck Artur 
Published: October 2015

Este artigo pretende levantar a questão da interlíngua na contemporaneidade, um processo de inter-relação entre línguas, resultante dos processos de mobilidade, migração, nomadismo, conflito armado, globalização, colonização, exílio e, mais recentemente, da interconectividade digital, ampliada para uma dimensão planetária. Estes processos, tornados possíveis e passíveis de ressignificação graças à comunicação mediática transnacional, têm desencadeado situações de contato interlinguístico, além e através das fronteiras geográficas das nações e do ciberespaço. DOI: http://dx.doi.org/10.14195/2182-8830_3-1_2
Perspectivas Colaborativas das Humanidades Digitais nas Investigações sobre William Blake
Authors: Di Palma Caio 
Published: October 2015

Recensão crítica à obra de Roger WHITSON & Jason WHITTAKER, William Blake and the Digital Humanities: Collaboration, Participation, and Social Media, London & New York, Routledge, 2013, 200 pp. ISBN 978-0-415-65618-4 DOI: http://dx.doi.org/10.14195/2182-8830_3-1_20
PO.EX: Arquivo, Subarquivo, Meta-arquivo
Authors: Marques Diogo 
Published: October 2015

Recensão crítica de Rui TORRES & Sandy BALDWIN, PO.EX: Essays from Portugal on Cyberliterature and Intermedia (By Pedro Barbosa, Ana Hatherly and E. M. de Melo e Castro). Morgantown, WV: Center for Literary Computing/ West Virginia University Press, 2014, 282 pp. ISBN 978-1-938228-74-2
DOI: http://dx.doi.org/10.14195/2182-8830_3-1_21
Uma Breve Introdução ao Estudo da Estética Ecomidiática
Authors: Kujawski Guilherme 
Published: October 2015

Em linhas gerais, o artigo busca compreender a produção de uma área específica da artemídia (arte em multimeios), voltada à elaboração de uma variante da arte ecológica (tentativamente chamada de ecomidiática) que contribua com a capacidade de resiliência de infraestruturas e formulações éticas preocupadas com o futuro da humanidade e do planeta. A linha de investigação, portanto, divide-se em dois eixos: 1º, índices de artistas, coletivos e designers envolvidos na pesquisa de sistemas computacionais não convencionais, infraestruturas alternativas e energias renováveis; 2º, as relações que se estabelecem entre uma produção artística ecomidiática e conceitos filosóficos aplicados para uma teoria acerca da responsabilidade. O artigo associa dois ramos da filosofia (estética e ética) e, em particular, engloba áreas como ciência da computação, ecologia, energias alternativas, entre outras. DOI: http://dx.doi.org/10.14195/2182-8830_3-1_3
The role of investor protection in corporate governance and accounting harmonization: Cross-country analysis in Asia
Authors: Wardhani Ratna 
Published: October 2015

The purpose of this research is to analyze the effect of law system for investor protection on implementation of corporate governance at company level and degree of convergence of local accounting standards to IFRS (International Financial Reporting Standards). The result shows that investor protection has positive effect on implementation of corporate governance and degree of convergence of local standard to IFRS. The evidence is consistent with the argument that firm can establish law environment well for their own, but the quality of corporate investor protection via implementation of corporate governance mechanisms will depend on efficiency of judicial system of the country where the firm operates; and the quality of accounting standard in one country is a signal of country’s commitment to investor protection in order to provide good protection for its investor; a country will tend to adopt higher quality of accounting standard to ensure financial reporting transparency. This indicates that investor protection can be the key to the quality of other governance mechanisms, both at institutional level such as accounting standards, and also at firm level such as corporate governance implementation.
The role of auditor in whistleblower system: The cases in Indonesia
Authors: Uswati Dewi Nurul Hasanah , Djuwito Djuwito , Wilopo Romanus 
Published: October 2015

In 2012, the Association of Certified Fraud Examiners stated that 43% of frauds are detected by tip money. The role of tips for the people is a crucial factor in disclosing frauds. Most often, company frauds are revealed by a whistle blower. This study attempts to observe the dimensions of the existence and role of the organization of internal auditors and the witness protection agency as external factors influencing an internal auditor to become a whistle-blower. It also explores the effects of the internal auditor competencies, the moral attitude of the internal auditor, and the ethical behavior of company’s internal auditors as internal factors influencing an internal auditor on being a whistle-blower. The independent auditors are considered as the population as they are often connected with the internal auditors. They need the information from the internal auditor about fraud or abuse in the company. Questionnaires were mailed to them and analyzed using Partial Least Squares. It showed that only the ethical behavior of company’s internal auditors influenced them to be whistle blowers coupled by a witness protection program. To develop sound corporate governance in Indonesia, a whistle blower system is needed with emphasis on a strong witness protection. At present, Indonesia does not have the whistle blower act.
FAKTOR? FAKTOR YANG MEMPENGARUHI MINAT MENGIKUTI PROGRAM PENDIDIKAN BREVET PAJAK DI STIE PERBANAS SURABAYA
Authors: Sarjono Bayu 
Published: October 2015

Tax certification of Education Progam is estabilished by STIE Perbanas Surabaya in the form of training for university students or external party. At this moment, the demand for a tax occountant or tax consultant keeps on increasing, moreover when the there is Law No. 28 Year 2007 about Taxation General Stipulation. This condition has the effect of effort performed by DJP in order to increase state revenue. Universities are expected produce the graduates with enough knowledge and skill of taxation. Tax certification training is expected to support the graduates' competency. This research tries to find out what factors those influence university students to be interested in joining the tax ceitification program at STIE Perbanas Surabaya. This research is quantitative research using multiple regression test. The respondents in this research consist of all members of tax certification of Level I and Level II. The data were collected by spreading direct questionnaires and performingFocus Group Discussion. The result of statistic test shows that only economic motivation variable has significant infiuence towards the interest to join tax certification program. They explain that they join the tax certification program in order to get ligal document that can be used to apply for a job and also because they think that they don iow any intention to become tax accountont or tax consultant.