bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of biologics on depressive symptoms in patients with psoriasis: a systematic review
Authors: Fleming P. , Roubille C. , Richer V. , Starnino T. , McCourt C. , McFarlane A. , Siu S. , Kraft J. , Lynde C. , Pope J.E. , Keeling S. , Dutz J. , Bessette L. , Bissonnette R. , Haraoui B. , Gulliver W.P. 
Published: December 2014

AbstractBackgroundTwenty to fifty percent of patients with psoriasis have depressive symptoms.ObjectiveTo describe the effects of biologics (tumour necrosis factor inhibitors [TNFi] or interleukin 12/23 inhibitors [IL‐12/23i]) on depressive symptoms in patients with psoriasis.MethodsElectronic databases were searched for randomized controlled trials (RCTs) examining the effects of biologics on depressive symptoms in adults with psoriasis.ResultsOf the 305 publications identified, three RCTs were included in a systematic review. In a trial evaluating ustekinumab, mean change in Hospital and Anxiety Depression Rating Scale at 24 weeks from baseline was 3.1 with ustekinumab (P < 0.001) vs. 0.21 with placebo (not significant). In a trial evaluating adalimumab, mean change in Zung Self‐Rating Depression Scale at 12 weeks from baseline was −6.7 with adalimumab vs. −1.5 with placebo. In a trial evaluating etanercept, the between‐group difference at 12 weeks in Beck Depression Inventory Scale was 1.8 (95% CI: 0.6, 2.90) in favour of etanercept over placebo. Limitations are that diagnostic criteria for depression were not used and scales and data from individual RCTs could not be combined.ConclusionAdalimumab, etanercept and ustekinumab were associated with statistically significant reductions in depressive symptom scores using various scales in patients with moderate‐to‐severe psoriasis.
Large moths captures by a pest monitoring system depend on farmland heterogeneity
Authors: Novotný D. , Zapletal M. , Kepka P. , Beneš J. , Konvička M. 
Published: December 2014

AbstractAs intensive farmlands cover increasing areas of the world, associated biotic richness is crucial for the biodiversity of entire regions. Using data on non‐target Macrolepidopteran moths captured by a crop pest monitoring system, we compared local (100 m perimeter)‐ and landscape‐scale (1000 m perimeter) predictors of the numbers of moth individuals and moth species richness. During a single year (2009), eighteen light traps captured 91 726 individuals of 564 moths species. Typically for biotically impoverished habitats, the catches were dominated by a few superabundant species. Even in these impoverished assemblages, numbers of species increased with increasing herb and woody plants diversity (100 m around the traps), crop diversity (1000 m perimeter), landscape composition (1000 m) and configuration (100 and 1000 m). Abundance of the catches increased only with woody plants diversity in 100 m perimeters. In separate analyses of two species‐rich families, the presumably less mobile Geometridae increased with landscape configuration (i.e. density of edges) within 100 m perimeters around the traps, whereas the species richness of more mobile Noctuidae also reflected the landscape composition (i.e. proportional representation of land covers) at 100 m perimeters. Proportional representation of pest species decreased with increasing richness of herb and woody plants. Taken together, farmland heterogeneity increases moth species richness, whereas abundance of the catches mainly depends on local factors in the vicinity of light traps, and the local factors are more important for presumably less mobile Geometridae than for more mobile Noctuidae.
Person‐centred health care: a critical assessment of current and emerging research approaches
Authors: Martin Carmel M. , Félix‐Bortolotti Margot 
Published: December 2014

AbstractRationale, aims and objectivesPerson‐centred health care is prominent in international health care reforms. A shift to understanding and improving personal care at the point of delivery has generated debates about the nature of the person‐centred research agenda. This paper purviews research paradigms that influence current person‐centred research approaches and traditions that influence knowledge foundations in the field. It presents a synthesis of the emergent approaches and methodologies and highlights gaps between static academic research and the increasing accessibility of evaluation, informatics and big data from health information systems.FindingsParadigms in health services research range from theoretical to atheoretical, including positivist, interpretive, postmodern and pragmatic. Interpretivist (subjective) and positivist (objectivist) paradigms have been historically polarized. Yet, integrative and pragmatic approaches have emerged. Nevertheless, there is a tendency to reductionism, and to reduce personal experiences to metrics in the positivist paradigm. Integrating personalized information into clinical systems is increasingly driven by the pervasive health information technology, which raises many issues about the asymmetry and uncertainty in the flow of information to support personal health journeys. The flux and uncertainty of knowledge between and within paradigmatic or pragmatic approaches highlights the uncertainty and the ‘unorder and disorder’ in what is known and what it means. Transdisciplinary, complex adaptive systems theory with multi‐ontology sense making provides an overarching framework for making sense of the complex dynamics in research progress.ConclusionA major challenge to current research paradigms is focus on the individualizing of care and enhancing experiences of persons in health settings. There is an urgent need for person‐centred research to address this complex process. A transdisciplinary and complex systems approach provides a sense‐making framework.
Analysing codon usage bias of cyprinid herpesvirus 3 and adaptation of this virus to the hosts
Authors: Ma Y P , Liu Z X , Hao L , Ma J Y , Liang Z L , Li Y G , Ke H 
Published: December 2014

AbstractThe codon usage patterns of open reading frames (ORFs) in cyprinid herpesvirus 3 (CyHV‐3) have been investigated in this study. The high correlation between GC12% and GC3% suggests that mutational pressure rather than natural selection is the main factor that determines the codon usage and base component in the CyHV‐3, while mutational pressure effect results from the high correlation between GC3% and the first principal axis of principle component analysis (Axis 1) on the relative synonymous codon usage (RSCU) value of the viral functional genes. However, the interaction between the absolute codon usage bias and GC3% suggests that other selections take part in the formation of codon usage, except for the mutational pressure. It is noted that the similarity degree of codon usage between the CyHV‐3 and goldfish, Carassius auratus (L.), is higher than that between the virus and common carp, Cyprinus carpio L., suggesting that the goldfish plays a more important role than the common carp in codon usage pattern of the CyHV‐3. The study of codon usage in CyHV‐3 can provide some evidence about the molecular evolution of the virus. It can also enrich our understanding about the relationship between the CyHV‐3 and its hosts by analysing their codon usage patterns.
Resistance to single‐agent chemotherapy and its risk factors in low‐risk gestational trophoblastic neoplasms
Authors: Mousavi Azam Sadat , Zamani Ashraf , Khorasanizadeh Faezeh , Gilani Mitra Modarres , Zendehdel Kazem 
Published: December 2014

AbstractAimGestational trophoblastic neoplasm (GTN) is a rare disease which is classified into high‐ and low‐risk groups. While the high‐risk patients require combination therapy, the low‐risk groups respond to single‐agent chemotherapy. We studied resistance to single‐agent chemotherapy and its risk factors among the low‐risk GTN patients in Iran.MethodsWe followed 168 low‐risk GTN patients who were treated between 2001 and 2011 in Valiasr Hospital, Tehran, Iran. We used a case–control design and studied odds ratios (OR) and corresponding 95% confidence intervals (CI) to evaluate association between drug resistance and different personal and clinical variables.ResultsResistance to sequential single‐agent chemotherapy was 19%, although all patients had a complete remission after a combination of chemotherapy and/or surgery. Patients who had International Federation of Gynecology and Obstetrics scores of 5–6 – considered as, the intermediate risk group – had a 14‐fold higher resistance compared with the low score patients (OR = 14.28, 95% CI = 5.54–36.81). We found higher risk of resistance among patients with metastasis (OR = 8.42, 95% CI = 2.44–29.07), large tumor size (>3 cm) (OR = 7.73, 95% CI = 1.93–30.91), high β‐hCG (>100 000 IU/L) (OR = 5.86, 95% CI = 1.07–32.02) and/or a diagnosis more than 4 months after pregnancy (OR = 3.30, 95% CI = 1.08–10.02), compared with their reference group. We found no priority for the different chemotherapy regimens.ConclusionIntermediate risk GTN patients had a higher risk of resistance to chemotherapy compared with low‐risk patients. Clinical trials and cost‐effectiveness studies are needed to suggest a better treatment program for the intermediate risk group.
Quality of life among women with symptoms of gynecological morbidities: Results of a cross‐sectional study in Karachi, Pakistan
Authors: Sami Neelofar , Ali Tazeen Saeed , Osama Muhammad 
Published: December 2014

AbstractAimsA population‐based cross‐sectional study design was used to study the effects of symptoms of various gynecological morbidities (GM) on health‐related quality of life (HRQoL) of women, residents of squatter settlements of Karachi, Pakistan.Material and MethodsThis cross‐sectional study was conducted in squatter settlements of Karachi from September 2012 to August 2013, with 1002 married, non‐pregnant women. After obtaining written informed consent from every participant, a structured questionnaire was used to collect information about symptoms of GM and their effect on four domains of HRQoL (physical, social, functional and financial domains).ResultsOf 1002 women who participated in the study, 578 reported suffering from one or more symptoms of GM. The most commonly reported symptoms were foul‐smelling vaginal discharge, dysmenorrhea and uterovaginal prolapse while the least reported symptom was post‐coital bleeding. Symptoms of GM were found to have a negative impact on HRQoL. Approximately one‐third of women with the symptoms of GM reported having negative influences on the physical, financial and functional domains of HRQoL with social domain being comparatively less affected. Compared to other symptoms, dysmenorrhea and uterovaginal prolapse were reported to be mostly associated with poor HRQoL of women.ConclusionThe concept of HRQoL has been kept marginal and inconspicuous by clinicians. In order to achieve the psychosocial satisfaction of the patient, the focus needs to be diverted to all domains of HRQoL.
Orai1 protein expression and the role of calcium release‐activated calcium channels in the contraction of human term‐pregnant and non‐pregnant myometrium
Authors: Sutovska Martina , Kocmalova Michaela , Sadlonova Vladimira , Dokus Karol , Adamkov Marian , Luptak Jan , Franova Sona 
Published: December 2014

AbstractAimThis experimental in vitro study examined differences in the expression and activity of calcium release‐activated calcium (CRAC) channels of human term‐pregnant and non‐pregnant myometrium.Material and MethodsThe tissue samples were obtained from term‐pregnant myometrium in labor of women undergoing cesarean section and from non‐pregnant myometrium of women undergoing total hysterectomy due to uterine myoma. The expression of Orai1 protein, a pore‐forming subunit of CRAC channels, in human myometrium was examined using immunohistochemistry. CRAC channel involvement in the amplitude and frequency of myometrial contractions was evaluated in vitro using a tissue bath method with a CRAC ion channel blocker 3‐fluropyridine‐4‐carboxylic acid (FPCA).ResultsDecreased Orai1 expression was observed in human term‐pregnant laboring myometrium compared with non‐pregnant myometrium. However, the initial oxytocin‐induced contraction of myometrium was significantly suppressed at different doses of FPCA in both non‐pregnant human isolated myometrium and non‐pregnant myometrium. The frequency of contractions was the most significantly reduced at the lowest dose of FPCA in non‐pregnant myometrium and remained suppressed at all doses of FPCA in term‐pregnant myometrium. Salbutamol was shown as more effective in suppression of amplitude in term‐pregnant isolated myometrium.ConclusionOur results provide the first information about the changes in the Orai1 protein expression and activity of human myometrial CRAC channels in term‐pregnant laboring myometrium.
Hysteroscopic transcervical resection is useful to diagnose myometrial invasion in atypical polypoid adenomyoma coexisting with atypical endometrial hyperplasia or endometrial cancer with suspicious myometrial invasion
Authors: Yamagami Wataru , Susumu Nobuyuki , Ninomiya Tomomi , Nakadaira Naoki , Iwasa Naomi , Kuwahata Michiko , Nomura Hiroyuki , Kataoka Fumio , Banno Kouji , Aoki Daisuke 
Published: December 2014

AbstractAimManagement of atypical polypoid adenomyoma (APAM) is complicated because it can sometimes coexist with atypical endometrial hyperplasia (AEH) or endometrioid adenocarcinoma. It is often difficult to assess myometrial invasion in APAM complicated with endometrial cancer. We encountered three patients who, contrary to magnetic resonance imaging, did not have myometrial invasion on hysteroscopic transcervical resection (TCR) and therefore could have fertility preserved, and consequently could become pregnant.MethodsWe removed the polypoid lesion and a 3–5 mm‐thick layer of the normal inner membrane at the root of the polypoid lesion, and then performed total curettage. Several pathological diagnostic procedures were then carried out on each of these resected specimens. Thereafter, high‐dose medroxyprogesterone acetate (MPA) was initiated.ResultsAll three patients underwent hysteroscopic transcervical tumor resection. The pathological diagnoses were as follows: patient 1, G1 endometrioid adenocarcinoma (EMG1) + APAM; patients 2,3, AEH + APAM. No findings of myometrial invasion in the resected root specimen were observed in any patient. In all cases, high‐dose MPA was initiated. After the disappearance of tumors, each patient achieved pregnancy. Complications such as placenta accreta were not observed at the time of delivery.ConclusionIn patients with APAM and AEH or EMG1, TCR may aid accurate diagnosis when myometrial invasion is unclear on diagnostic imaging.
Effect of UV‐C Radiation on Resistance of Romaine Lettuce (Lactuca sativa L.) Against Botrytis cinerea and Sclerotinia minor
Authors: Ouhibi Chayma , Attia Houneida , Nicot Philippe , Urban Laurent , Lachaâl Mokhtar , Aarrouf Jawad 
Published: December 2014

AbstractThe aim of this research was to examine the effect of UV‐C on resistance of lettuce to Botrytis cinerea and Sclerotinia minor. Analysis of the lesion surfaces showed that plants exposed to UV‐C were less susceptible to the two pathogens, especially on the fourth day after inoculation. Chlorophyll, carotenoid contents and malondialdehyde and hydrogen peroxide were assayed after 1 day and 4 days. Lettuces treated with UV‐C and inoculated showed an increase in chlorophyll and carotenoid content, especially 24 h after inoculation, and low values of the two indicators of oxidative stress as compared with lettuces which were inoculated but did not receive UV‐C treatment.
Association analysis between 8-oxoguanine DNA glycosylase genetic variants and endometrial cancer susceptibility in Chinese Han population
Authors: Wang Lijuan , Li Jing , Lu Huaiwu , Zhou Hui , Xie Lingling , Wu Miaofang , Lin Zhongqiu 
Published: December 2014

Abstract

Objectives
Numerous epidemiologic studies demonstrate that 8-oxoguanine DNA glycosylase gene (hOGG1) is an important candidate gene for the development of endometrial cancer (EC). The objective of this study is to evaluate the potential association between hOGG1 genetic variants and the susceptibility to EC.

Methods
In total, 218 EC patients and 243 cancer-free controls were recruited in this study.

Key findings
Our data indicate that the hOGG1 c.269C &gt; A and c.828A &gt; G genetic variants are statistically associated with the increased susceptibility to EC (for c.269C &gt; A, AA vs CC: odds ratio (OR) = 2.14, 95% confidence interval (CI), 1.21 to 3.78, P = 0.008; A vs C: OR = 1.43, 95% CI, 1.09 to 1.88, P = 0.010; for c.828A &gt; G, GG vs AA: OR = 2.31, 95% CI, 1.24 to 4.30, P = 0.008; G vs A: OR = 1.35, 95% CI, 1.03 to 1.78, P = 0.032). The A allele and AA genotype of c.269C &gt; A and G allele and GG genotype of c.828A &gt; G genetic variants could contribute to the susceptibility to EC.

Conclusion
Taken together, our findings suggest that the hOGG1 c.269C &gt; A and c.828A &gt; G genetic variants are significantly associated with EC susceptibility in Chinese Han populations and might be used as molecular markers for assessing the risk of EC.
Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7
Authors: Wu Zhufeng , Liu Hongming , Wu Baojian 
Published: December 2014

Abstract

Objectives
To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and to identify the main UGT enzymes involved in regioselective glucuronidation of gingerols.

Methods
The rates of glucuronidation were determined by incubating the gingerols with uridine diphosphoglucuronic acid-supplemented microsomes. Kinetic parameters were derived by fitting an appropriate model to the data. Activity correlation analyses were performed to identify the main UGT enzymes contributing to hepatic metabolism of gingerols.

Key findings
Glucuronidation at the 4′-OH group was much more favoured than that at 5-OH. The degree of position preference was compound-dependent; the catalytic efficiency ratios of 4′-O- to 5-O-glucuronidation were 9.1, 19.7 and 2.9 for 6-, 8- and 10-gingerol, respectively. UGT1A8 (an intestinal enzyme), UGT1A9 and UGT2B7 were the enzymes showing the highest activity towards gingerols. Formation of 5-O-glucuronide was mainly catalysed by UGT1A9. UGT2B7 was the only enzyme that generated glucuronides at both 4′-OH and 5-OH sites, although a strong position preference was observed with 4′-OH (≥80.2%). Further, activity correlation analyses indicated that UGT2B7 and UGT1A9 were primarily responsible for 4′-O-glucuronidation and 5-O-glucuronidation of gingerols in the liver, respectively.

Conclusions
Gingerols were metabolized by multiple hepatic and gastrointestinal UGT enzymes. Also, UGT1A9 and 2B7 were the main contributors to regioselective glucuronidation of gingerols in the liver.
A numerical tool to predict ice growth in lakes
Authors: Toniolo Horacio 
Published: December 2014

AbstractOil and gas exploration activities on the North of Slope of Alaska rely on ice roads to provide access to the exploration sites, with negligible effects on the tundra. The construction of ice roads requires a large volume of water which, in turn, poses challenges to water resource managers. A tool capable of predicting ice thickness in a given lake could certainly benefit the oil industry. This study focuses on the development and use of such a predictive tool. Using a simplified Stefan equation, the tool is based on a combination of three weather scenarios (warm, average and cold winters), current winter condition and ice thickness measurements. It was applied to four lakes located on the Arctic Coastal Plain and one lake in the foothill area. The study results indicate the model predictions are relatively accurate (7% average percentage error) for monthly time spans. The study results also reveal a temporal variation in a coefficient used in the calculations, although previous literature utilized a constant coefficient to estimate the ice thickness.
High‐stakes species delimitation in eyeless cave spiders (Cicurina, Dictynidae, Araneae) from central Texas
Authors: Hedin Marshal 
Published: December 2014

AbstractA remarkable radiation of completely eyeless, cave‐obligate spider species (Cicurina) has been described from limestone caves of Texas. This radiation includes over 50 described species, with a large number of hypothesized single‐cave endemics, and four species listed as US Federally Endangered. Because of this conservation importance, species delimitation in the group is ‘high‐stakes’– it is imperative that species hypotheses are data rich, objective, and robust. This study focuses on a complex of four cave‐dwelling Cicurina distributed on the northwestern edge of Austin, Texas. Several of the existing species hypotheses in this complex are weak, based on morphological comparisons of small samples of adult female specimens; one species description (for C. wartoni) is based on a single adult specimen. Species limits in this group were newly assessed using morphological, mitochondrial and nuclear DNA sequence data evidence, analysed using a variety of approaches. All data support a clear lineage separation between C. buwata versus the C. travisae complex (including C. travisae, C. wartoni and C. reddelli). Observed congruence across multiple analyses indicate that the C. travisae complex represents a single species, and the formal species synonymy presented here has important conservation implications. The integrative framework utilized in this study serves as a potential model for other Texas cave Cicurina, including US Federally Endangered species. More generally, this study illustrates how and why taxon‐focused conservation efforts must prioritize modern species delimitation research (if the existing taxonomy is weak), before devoting precious downstream resources to conservation efforts. The study also highlights the issue of taxonomic type II error that diversity biologists increasingly face as species delimitation moves into the genomics era.
The disruption of prenylation leads to pleiotropic rearrangements in cellular behavior in Staphylococcus aureus
Authors: Krute Christina N. , Carroll Ronan K. , Rivera Frances E. , Weiss Andy , Young Ryan M. , Shilling Andrew , Botlani Mohsen , Varma Sameer , Baker Bill J. , Shaw Lindsey N. 
Published: December 2014

SummaryPrenylation is the addition of prenyl groups to peptide chains or metabolites via the condensation of geranyl‐ or isopentenyl‐diphosphate moieties by geranyltranstransferases. Although this process is extensively studied in eukaryotes, little is known about the influence of prenylation in prokaryotic species. To explore the role of this modification in bacteria, we generated a mutation in the geranyltranstransferase (IspA) of Staphylococcus aureus. Quite strikingly, the ispA mutant completely lacked pigment and exhibited a previously undescribed small colony variant‐like phenotype. Further pleiotropic defects in cellular behavior were noted, including impaired growth, decreased ATP production, increased sensitivity to oxidative stress, increased resistance to aminoglycosides and cationic antimicrobial peptides, and decreased resistance to cell wall‐targeting antibiotics. These latter effects appear to result from differences in envelope composition as ispA mutants have highly diffuse cell walls (particularly at the septum), marked alterations in fatty acid composition and increased membrane fluidity. Taken together, these data present an important characterization of prokaryotic prenylation and demonstrate that this process is central to a wealth of pathways involved in mediating cellular homeostasis in S. aureus.