bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Epidemiologic Internet Survey of Fibromyalgia and Chronic Pain in Japan
Authors: Nakamura Ikuro , Nishioka Kenya , Usui Chie , Osada Kenichi , Ichibayashi Hisao , Ishida Mitsuhiro , Turk Dennis C. , Matsumoto Yoshifuji , Nishioka Kusuki 
Published: January 2014

ObjectiveTo determine the epidemiologic features and symptom characteristics of fibromyalgia (FM) in Japan, and compare them with those for other chronic pain (CP) diagnoses.MethodsAn internet survey was conducted in June and July 2011. The questionnaire consisted of 111 questions, including assessments of the Japanese version of the 2010 American College of Rheumatology preliminary diagnostic criteria for FM, the Japanese Fibromyalgia Impact Questionnaire, and additional questions regarding pain and lifestyle.ResultsThe questionnaire was completed by 20,407 male and female respondents in all prefectures of Japan. Of the survey population, 2,524 respondents (12.4%) reported symptoms consistent with CP; of these, 425 (2.1%) reported symptoms consistent with FM. Among respondents with FM and CP, 61% and 53%, respectively, were women. Pain severity and Widespread Pain Index scores were significantly higher in respondents meeting the diagnostic criteria for FM than in those meeting the criteria for CP. In terms of symptom severity scores, the proportions of respondents reporting the 3 major symptoms as “highly applicable” and greater numbers of 41 somatic symptoms were higher among respondents with FM than among those with CP. The incidence of FM in the present survey was similar to that reported (1.7%) in a study of FM in Japan in 2003, despite the use of the newer, easier to use 2010 diagnostic criteria.ConclusionBecause FM usually presents with more severe and more widely distributed pain, as well as more nonpainful symptoms than CP, our results suggest that FM is a different clinical phenotype of CP.
“We're All Looking for Solutions”: A Qualitative Study of the Management of Knee Symptoms
Authors: MacKay Crystal , Badley Elizabeth M. , Jaglal Susan B. , Sale Joanna , Davis Aileen M. 
Published: January 2014

ObjectiveWhile the prevalence of osteoarthritis (OA) increases with age, the first signs begin in the fourth or fifth decade. Little is known about how younger adults respond to OA. This study explores how people ages 35–65 years manage knee symptoms.MethodsSix focus groups were conducted with 41 participants (mean age 50.9 years, 63% women) who self‐reported a diagnosis of OA or reported knee symptoms (i.e., pain, aching, or stiffness) on most days of the past month. Purposive sampling was used, seeking variation in age and sex. The principles of constructivist grounded theory guided data collection and analysis. Data were analyzed using a constant comparative method.ResultsParticipants engaged in a process of proactively trying to find ways to control knee symptoms and disease progression. Their approach to management was not linear, but rather a process that moved back and forth between searching for “solutions” and active management (ongoing use of strategies). During the process, participants consulted health care providers, but often perceived that medical care offered limited options and guidance. Management was constructed as a “never‐ending” process that entailed effort and personal resources.ConclusionParticipants were proactive in seeking ways to manage knee OA symptoms. There is a mismatch between participants' proactive approach and the reactive approach of the health care system that has focused on late‐stage disease. Programs and supports within the formal and informal health care system are required to enable people to successfully manage knee symptoms across their lifespan.
IR‐Nachweis der bei der β‐Pinen‐Ozonolyse gebildeten Criegee‐ Intermediate und ihre Reaktivität gegenüber Schwefeldioxid
Authors: Ahrens Jennifer , Carlsson Philip T. M. , Hertl Nils , Olzmann Matthias , Pfeifle Mark , Wolf J. Lennard , Zeuch Thomas 
Published: January 2014

AbstractKinetikexperimente haben vor kurzem ergeben, dass die Oxidation von Schwefeldioxid zu Schwefeltrioxid durch stabilisierte Criegee‐Intermediate (CIs) eine wichtige Quelle für Schwefelsäure in der Atmosphäre ist. Bislang waren nur kleine, durch Photolyse erzeugte CIs direkt nachgewiesen worden. Hier wird gezeigt, dass große, in der Gasphase stabilisierte CIs während der Ozonolyse von β‐Pinen durch FT‐IR‐Spektroskopie detektiert werden können. Ihr Absorptionsmuster zwischen 930 und 830 cm−1 tritt nur zu Beginn der Ozonolyse auf, wenn das Abfangen der stabilisierten CIs durch Reaktionsprodukte langsam ist. Die großen CIs reagieren mit Schwefeldioxid in einer Ausbeute >80 % zu Schwefeltrioxid und Nopinon. Der Reaktantenverbrauch und die Produktbildung bei zeitaufgelösten Experimenten zur Ozonolyse von β‐Pinen in Gegenwart von Schwefeldioxid wurden kinetisch modelliert. Die Ergebnisse sprechen für eine schnelle Reaktion der CIs aus der β‐Pinen‐Ozonolyse mit Schwefeldioxid.
Nickel‐Catalyzed Mizoroki–Heck Reaction of Aryl Sulfonates and Chlorides with Electronically Unbiased Terminal Olefins: High Selectivity for Branched Products
Authors: Tasker Sarah Z. , Gutierrez Alicia C. , Jamison Timothy F. 
Published: January 2014

AbstractAchieving high selectivity in the Heck reaction of electronically unbiased alkenes has been a longstanding challenge. Using a nickel‐catalyzed cationic Heck reaction, we were able to achieve excellent selectivity for branched products (≥19:1 in all cases) over a wide range of aryl electrophiles and aliphatic olefins. A bidentate ligand with a suitable bite angle and steric profile was key to obtaining high branched/linear selectivity, whereas the appropriate base suppressed alkene isomerization of the product. Although aryl triflates are traditionally used to access the cationic Heck pathway, we have shown that, by using triethylsilyl trifluoromethanesulfonate, we can effect a counterion exchange of the catalytic nickel complex, such that cheaper and more stable aryl chlorides, mesylates, tosylates, and sulfamates can be used to yield the same branched products with high selectivity.
Rational Design of Modular Polyketide Synthases: Morphing the Aureothin Pathway into a Luteoreticulin Assembly Line
Authors: Sugimoto Yuki , Ding Ling , Ishida Keishi , Hertweck Christian 
Published: January 2014

AbstractThe unusual nitro‐substituted polyketides aureothin, neoaureothin (spectinabilin), and luteoreticulin, which are produced by diverse Streptomyces species, point to a joint evolution. Through rational genetic recombination and domain exchanges we have successfully reprogrammed the modular (type I) aur polyketide synthase (PKS) into a synthase that generates luteoreticulin. This is the first rational transformation of a modular PKS to produce a complex polyketide that was initially isolated from a different bacterium. A unique aspect of this synthetic biology approach is that we exclusively used genes from a single biosynthesis gene cluster to design the artificial pathway, an avenue that likely emulates natural evolutionary processes. Furthermore, an unexpected, context‐dependent switch in the regiospecificity of a pyrone methyl transferase was observed. We also describe an unprecedented scenario where an AT domain iteratively loads an extender unit onto the cognate ACP and the downstream ACP. This aberrant function is a novel case of non‐colinear behavior of PKS domains.
Template‐Free Preparation of Volvox‐like CdxZn1−xS Nanospheres with Cubic Phase for Efficient Photocatalytic Hydrogen Production
Authors: Zhou Hangyue , Liu Qingyun , Liu Weimin , Ge Jiechao , Lan Minhuan , Wang Chao , Geng Jianxin , Wang Pengfei 
Published: January 2014

AbstractVolvox‐like CdxZn1−xS solid solutions with a cubic zinc blend structure were synthesized through a template‐free ethylene glycol process. Cd(Ac)2⋅2 H2O, Zn(Ac)2⋅2 H2O, and thiourea are used as the starting materials and dissolved in ethylene glycol. These reaction precursors and solvent not only contributed to control over the formation of the volvox‐like spherical geometry, but also exerted vigorous domination for existence of cubic‐phase CdxZn1−xS nanostructures. As‐prepared volvox‐like CdxZn1−xS nanospheres have a diameter of around 100 nm with extensional shells. These samples show excellent photocatalytic H2 evolution activity from water splitting under visible‐light irradiation without any cocatalyst or scaffolding, owing to their tunable band gap, cubic zinc blend structure, and unique hierarchical porous structure with a high surface area (as high as 95.2 m2 g−1).
Randomized clinical trial of stapler versus clamp-crushing transection in elective liver resection
Authors: Rahbari N N , Elbers H , Koch M , Vogler P , Striebel F , Bruckner T , Mehrabi A , Schemmer P , Büchler M W , Weitz J 
Published: January 2014

Abstract

Background
Various devices have been developed to facilitate liver transection and reduce blood loss in liver resections. None of these has proven superiority compared with the classical clamp-crushing technique. This randomized clinical trial compared the effectiveness and safety of stapler transection with that of clamp-crushing during open liver resection.

Methods
Patients admitted for elective open liver resection between January 2010 and October 2011 were assigned randomly to stapler transection or the clamp-crushing technique. The primary endpoint was the total amount of intraoperative blood loss. Secondary endpoints included transection time, duration of operation, complication rates and resection margins.

Results
A total of 130 patients were enrolled, 65 to clamp-crushing and 65 to stapler transection. There was no difference between groups in total intraoperative blood loss: median (i.q.r.) 1050 (525–1650) versus 925 (450–1425) ml respectively (P = 0·279). The difference in total intraoperative blood loss normalized to the transection surface area was not statistically significant (P = 0·092). Blood loss during parenchymal transection was significantly lower in the stapler transection group (P = 0·002), as were the parenchymal transection time (mean(s.d.) 30(21) versus 9(7) min for clamp-crushing and stapler transection groups respectively; P &lt; 0·001) and total duration of operation (mean(s.d.) 221(86) versus 190(85) min; P = 0·047). There were no significant differences in postoperative morbidity (P = 0·863) or mortality (P = 0·684) between groups.

Conclusion
Stapler transection is a safe technique but does not reduce intraoperative blood loss in elective liver resection compared with the clamp-crushing technique. Registration number: NCT01049607 (http://www.clinicaltrials.gov).
Catalytic Combustion of Ethyl Acetate over Manganese Oxides Deposited on Metallic Monoliths
Authors: Durán Flavia G. , Barbero Bibiana P. , Cadús Luis E. 
Published: January 2014

AbstractMnOx/AISI 304 austenitic stainless‐steel monolithic catalysts were prepared by impregnation with aqueous solutions of manganese nitrate or acetate. The preparation method was satisfactory in terms of reproducibility and adherence of the deposited phase. The use of different precursors led to significantly dissimilar results. With manganese nitrate, the formation of Mn‐Cr‐O mixed phases on the surface was favored, whereas with manganese acetate, Mn2O3 was the predominant active phase. The Mn‐Cr‐O mixed phases would be highly dispersed but their catalytic activity was low. The major catalytic behavior was obtained with monoliths impregnated with manganese acetate.
Porous MII/Pyrimidine‐4,6‐Dicarboxylato Neutral Frameworks: Synthetic Influence on the Adsorption Capacity and Evaluation of CO2‐Adsorbent Interactions
Authors: Cepeda Javier , Pérez‐Yáñez Sonia , Beobide Garikoitz , Castillo Oscar , Fischer Michael , Luque Antonio , Wright Paul A. 
Published: January 2014

AbstractThe understanding of the factors that affect the real pore‐network structure for a given bulk material due to different synthetic procedures is essential to develop the material with the best adsorption properties. In this work, we have deeply studied the influence of the crystallinity degree over the adsorption capacity on three new isostructural MOFs with the formula {[CdM(μ4‐pmdc)2(H2O)2]⋅solv}n (in which, pmdc=pyrimidine‐4,6‐dicarboxylate; solv=corresponding solvent; MII=Cd (1), Mn (2), Zn (3)). Compared with other methods, the solvent‐free synthesis stands as the most effective route because, apart from enabling the preparation of the heterometallic compounds 2 and 3, it also renders the adsorbents with the highest performance, which is indeed close to the expected one derived from Grand Canonical Monte Carlo (GCMC) calculations. The structural analysis of the as‐synthesised and evacuated frameworks reveals the existence of a metal atom exposed to the pore. The accessibility of this site is limited due to its atomic environment, which is why it is considered as a pseudo‐open‐metal site. The chemical and physical characterisation confirms that this site can be modified as the metal atom is replaced in compounds 2 and 3. To assess the effect of the metal replacement on the adsorption behaviour, an exhaustive study of CO2 experimental isotherms has been performed. The affinity of the pseudo‐open metal sites towards CO2 and the distribution of the preferred adsorption sites are discussed on the basis of DFT and GCMC calculations.
How Water Interacts with Halogenated Anesthetics: The Rotational Spectrum of Isoflurane–Water
Authors: Gou Qian , Feng Gang , Evangelisti Luca , Vallejo‐López Montserrat , Spada Lorenzo , Lesarri Alberto , Cocinero Emilio J. , Caminati Walther 
Published: January 2014

AbstractThe rotational spectra of several isotopologues of the 1:1 complex between the inhaled anesthetic isoflurane and water have been recorded and analyzed by using Fourier transform microwave spectroscopy. The rotational spectrum showed a single rotamer, corresponding to the configuration in which the most stable conformer of isolated isoflurane is linked to the water molecule through an almost linear CH⋅⋅⋅O weak hydrogen bond. All transitions display a hyperfine structure due to the 35Cl (or 37Cl) nuclear quadrupole effects.
The Mechanism of Gold(I)‐Catalyzed Hydroalkoxylation of Alkynes: An Extensive Experimental Study
Authors: Zhdanko Alexander , Maier Martin E. 
Published: January 2014

AbstractAn extensive experimental study of the mechanism of gold(I)‐catalyzed hydroalkoxylation of internal alkynes has been conducted by using NMR spectroscopy. This study was focused on the organogold intermediates, observations of actual catalytic intermediates in situ, and the reaction kinetics that are involved in this reaction. Based on the experimental results, a complete mechanistic picture was established, including on‐ and off‐cycle processes that explain the role of diaurated species. We have shown that gold‐catalyzed hydroalkoxylation of internal alkynes is a reaction that requires only one gold atom for the catalytic cycle, disproving a recent hypothesis regarding the involvement of cooperative gold catalysis.
A Maillard Approach to 2‐Formylpyrroles: Synthesis of Magnolamide, Lobechine and Funebral
Authors: Yuen Tsz‐Ying , Eaton Samantha E. , Woods Tom M. , Furkert Daniel P. , Choi Ka Wai , Brimble Margaret A. 
Published: January 2014

AbstractA convenient synthesis of the traditional medicine constituents magnolamide, lobechine and funebral is described. Construction of the 2‐formylpyrrole core of these natural products was achieved by means of a Maillard reaction, involving condensation of the sugar surrogate, dihydropyranone 9, with the requisite primary amines. This approach offers a very direct and general route to the 2‐formylpyrrole ring system.
Serial diffusion tensor imaging for early detection of radiation‐induced injuries to normal‐appearing white matter in high‐grade glioma patients
Authors: Hope Tuva R. , Vardal Jonas , Bjørnerud Atle , Larsson Christopher , Arnesen Marius R. , Salo Raimo A. , Groote Inge R. 
Published: January 2014

PurposeTo study the potential of diffusion tensor imaging (DTI) to serve as a biomarker for radiation‐induced brain injury during chemo‐radiotherapy (RT) treatment.Materials and MethodsSerial DTI data were collected from 18 high‐grade glioma (HGG) patients undergoing RT and 7 healthy controls. Changes across time in mean, standard deviation (SD), skewness, and kurtosis of fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (λa), and transversal diffusivity (λt) within the normal‐appearing white matter (NAWM) were modeled using a linear mixed‐effects model to assess dose dependent changes of five dose bins (0–60 Gy), and global changes compared with a control group.ResultsMean MD, λa and λt were all significantly increasing in >41 Gy dose regions (0.14%, 0.10%, and 0.18% per week) compared with <12 Gy regions. SD λt had significant dose dependent time evolution of 0.019*dose per week. Mean and SD MD, λa and λt in the global NAWM of the patient group significantly increased (mean; 0.06%, 0.03%, 0.09%, and SD; 0.57%, 0.34%, 0.51 per week) compared with the control group. The changes were significant at week 6 of, or immediately after RT.ConclusionDTI is not sensitive to acute global NAWM changes during the treatment of HGG, but sensitive to early posttreatment changes. J. Magn. Reson. Imaging 2015;41:414–423.© 2013 Wiley Periodicals, Inc.
The increase in prescriptions of bisphosphonates and the incidence proportion of osteonecrosis of the jaw after risk communication activities in Japan: a hospital‐based cohort study
Authors: Sumi Eriko , Yamazaki Toru , Tanaka Shiro , Yamamoto Keiichi , Nakayama Takeo , Bessho Kazuhisa , Yokode Masayuki 
Published: January 2014

ABSTRACTPurposeThe purpose of this study was to investigate the impact of risk communication about bisphosphonate (BP)‐related osteonecrosis of the jaw (ONJ) on the number of reported cases to the Drug Adverse Reactions Reporting System and on the incidence proportion of ONJ in a hospital‐based cohort study in Japan.MethodWe conducted a survey of the safety information on BP‐related ONJ available from regulatory authorities, pharmaceutical manufacturers and academic associations. We also performed a trend analysis of a dataset from the Drug Adverse Reactions Reporting System and a sub‐analysis, using previously constructed data from a retrospective cohort study.ResultsRisk communication from pharmaceutical manufacturers and academic associations began within 1 year after revisions were made to the package inserts, in October 2006. Twenty times more cases of ONJ have been reported to regulatory authority since 2007, compared with the period before 2007. In our cohort, the incidence proportion of ONJ during and after 2009 was four times greater than before 2009. During this period, BPs were frequently prescribed, whereas there was no increase in the use of alternative agents, such as selective estrogen receptor modulators.ConclusionONJ was increasingly diagnosed after risk communication efforts, but the impact of the communications was not clear. Safety notifications were diligently disseminated after the package insert was revised. However, there was no surveillance for ONJ before the revision. © 2014 The Authors. Pharmacoepidemiology and Drug Safety published by John Wiley & Sons, Ltd.
The effect of carbon‐doped In3Sb1Te2 ternary alloys for multibit (MLC) phase‐change memory
Authors: Kim Hyun Soo , Kim Yong Tae , Hwang Ha Sub , Sung Man Young 
Published: January 2014

AbstractOne of the candidate materials for phase‐change memory, In3Sb1Te2 (IST), shows multilevel phase transformations from amorphous to several crystalline materials of IST, intermediate phases such as InSb, SbTe and InTe. However, its volume can change abruptly in the multilevel phase transformation, and this change can lead to vacancy movement and atomic migration, which are related to failures and reliability issues. We propose the carbon‐incorporated In3Sb1Te2 (IST‐C) alloy, which has higher retention ability than the IST ternary alloy. Carbon atoms delay crystallization and prevent volume change during the set/reset operation. The carbon concen‐ tration is 12.5%, and the activation energy increases from 5.1 eV to 5.4 eV. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Quality of service‐aware and security‐aware dynamic spectrum management in cyber‐physical surveillance systems for transportation
Authors: Si Pengbo , Liu Jia , Sun Yanhua , Zhang Yanhua 
Published: January 2014

AbstractCyber‐physical system has been widely used in various areas as the integration of computing and physical system. As a typical application of cyber‐physical system, cyber‐physical surveillance system for transportation (CPSST) allows real‐time video monitoring to facilitate the deploying of smart transportation systems. For video streaming in CPSST, dynamic radio spectrum management is a key technology dealing with the current situation that the spectrum resource is almost used up. In this paper, taking into account the application layer quality of service and wireless link security, a novel dynamic spectrum management scheme has been proposed to minimize the system cost of CPSST. Video distortion is considered as the application layer quality of service metric, and the system cost is defined as a combination of distortion and security cost. We use intra‐refreshing rate in video coding to minimize the distortion. Furthermore, the problem is formulated as a restless bandit system, which uses current and historical information to optimize the action, with the objective of maximizing the total discounted system reward. We also describe the two spectrum management processes. Extensive simulation results are presented to demonstrate the significant performance improvement of the proposed scheme compared with the existing one that ignores video distortion and subband security optimization. Copyright © 2014 John Wiley & Sons, Ltd.
Nuclear quadrupole moment-induced Cotton-Mouton effect in molecules
Authors: Fu Li-juan , Vaara Juha 
Published: January 2014

Nuclear magneto-optic effects could make important contributions to novel, high-sensitivity, and high-resolution spectroscopic and imaging methods that provide nuclear site-specific structural and dynamic information on molecular and materials systems. Here we present a first-principles electronic structure formulation of nuclear quadrupole moment-induced Cotton-Mouton effect in terms of response theory, as well as ab initio and density-functional theory calculations of this phenomenon for a series of molecular liquids: H2O, CH3NO2, CH3CH2OH, C6H6, C6H12 (cyclohexane), HI, XeF2, WF5Cl, and Pt(C2dtp)2. The roles of basis-set convergence, electron correlation, and relativistic effects are discussed. The estimated order of magnitude of the overall ellipticities induced to linearly polarized light is 10−3–10−7 rad/(M cm) for fully spin polarized nuclei. The cases with the largest presently obtained ellipticities should be detectable with modern instrumentation in the Voigt magneto-optic setup, particularly for the heavy nuclei.
Comment on “The paradox of the ‘paradox of the plankton’” by Record et al.
Authors: Cropp Roger , Norbury John 
Published: January 2014

AbstractCropp, R., and Norbury, J. 2014. Comment on “The paradox of the ‘paradox of the plankton’” by Record et al. – ICES Journal of Marine Science, 71: 293–295. The biodiversity of plankton ecosystems is no longer a paradox. The mathematical mechanisms that determine the coexistence of competitors in a general class of models, which includes almost all theoretical and applied mass conserving ecosystem models in present use, are clear. Knowledge of these mechanisms simplifies the identification and construction of models with the structural property that all species coexist for all time, irrespective of environmental forcings, spatial interactions, and further model complexities. Here, we discuss the “paradox of the ‘paradox of the plankton’” proposed by Record et al. (ICES Journal of Marine Science, 71: 236–240) and explain the mechanisms that underpin the solution.