bluuebunny/crossref_metadata_2025_split huggingface dataset:
Differential sensitivity of nitrifying bacteria to silver nanoparticles in activated sludge
Authors: Yang Yu , Li Mengyan , Michels Camila , Moreira-Soares Hugo , Alvarez Pedro J.J. 
Published: July 2014

Abstract

Nitrification is known as one of the most sensitive processes affected when activated sludge is exposed to antimicrobial silver nanoparticles (AgNPs). The impact of AgNPs and their released silver ions (Ag+) on the abundance, activity, and diversity of different nitrifying bacteria in wastewater treatment plants (WWTPs), however, is poorly understood. The present study investigated the impacts of 2 sizes of AgNPs (5 nm and 35 nm) and Ag+ ions on the nitrifier community in activated sludge, including both ammonia-oxidizing bacteria (AOB) and nitrite-oxidizing bacteria (NOB). Ammonia-oxidizing bacteria were more sensitive to AgNPs than the NOB; a 5-d and 7-d exposure of activated sludge to 35 nm AgNPs (40 ppm) significantly reduced AOB abundance to 24% and 19%, respectively. This finding was confirmed further by a decrease in activated sludge ammonia oxidation activity measured by 14C-labeled bicarbonate uptake. In contrast, neither AgNPs (up to 40 ppm) nor Ag+ (1 ppm) affected the abundance of NOB. Both 5 nm and 35 nm AgNPs decreased the diversity of AOB, as indicated by denaturing gradient gel electrophoresis with ammonia monooxygenase gene (amoA) primers, although some unknown Nitrosomonas species were relatively resistant to AgNPs. The generally greater resistance of NOB than AOB to AgNPs suggests that the accumulation of bacteriostatic nitrite in WWTPs is unlikely to be exacerbated due to the accidental or incidental release of AgNPs. Environ Toxicol Chem 2014;33:2234–2239. © 2014 SETAC
The default mode network is disrupted in parkinson's disease with visual hallucinations
Authors: Yao Nailin , Shek‐Kwan Chang Richard , Cheung Charlton , Pang Shirley , Lau Kui Kai , Suckling John , Rowe James B. , Yu Kevin , Ka‐Fung Mak Henry , Chua Siew‐Eng , Ho Shu Leong. , McAlonan Grainne M. 
Published: July 2014

AbstractBackground: Visual hallucinations (VH) are one of the most striking nonmotor symptoms in Parkinson's disease (PD), and predict dementia and mortality. Aberrant default mode network (DMN) is associated with other psychoses. Here, we tested the hypothesis that DMN dysfunction contributes to VH in PD. Methods: Resting state functional data was acquired from individuals with PD with VH (PDVH) and without VH (PDnonVH), matched for levodopa drug equivalent dose, and a healthy control group (HC). Independent component analysis was used to investigate group differences in functional connectivity within the DMN. In addition, we investigated whether the functional changes associated with hallucinations were accompanied by differences in cortical thickness. Results: There were no group differences in cortical thickness but functional coactivation within components of the DMN was significantly lower in both PDVH and PDnonVH groups compared to HC. Functional coactivation within the DMN was found to be greater in PDVH group relative to PDnonVH group. Conclusion: Our study demonstrates, for the first time that, within a functionally abnormal DMN in PD, relatively higher “connectivity” is associated with VH. We postulate that aberrant connectivity in a large scale network affects sensory information processing and perception, and contributes to “positive” symptom generation in PD. Hum Brain Mapp 35:5658–5666, 2014. © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
CORRECTION OF MISCLASSIFICATION ERROR IN DISABILITY RATES
Authors: Gosling Amanda , Saloniki Eirini‐Christina 
Published: July 2014

ABSTRACTThis paper examines misclassification error in survey estimates of disability. The results suggest that a significant number of those with a disability fail to be recorded as such in the British Household Panel Survey. In addition, the probability of a false positive is estimated as being very close to zero in all socio‐demographic groups. There is a strong bias in estimates of differences in rates of disability across groups but only a small effect on estimates of the difference in employment rates by disability status. Copyright © 2014 John Wiley & Sons, Ltd.
Regulation of tumor progression via the Snail‐RKIP signaling pathway by nicotine exposure in head and neck squamous cell carcinoma
Authors: Nieh Shin , Jao Shu‐Wen , Yang Chin‐Yuh , Lin Yaoh‐Shiang , Tseng Yi‐Han , Liu Chia‐Lin , Lee Tsai‐Yu , Liu Tsung‐Yun , Chu Yueng‐Hsiang , Chen Su‐Feng 
Published: July 2014

AbstractBackgroundRecent studies suggest that long‐term exposure of the carcinogen 4‐methylnitrosamino‐1–3‐pyridyl‐1‐butanone (NNK) found in tobacco smoke is involved in the progression of head and neck squamous cell carcinoma (HNSCC). The underlying nicotine‐mediated mechanism remains unclear.MethodsAn analysis of SCC‐25 and Fadu cells with or without NNK exposure focusing on the evaluation of migration and invasion abilities, the expression of epithelial–mesenchymal transition, drug‐resistance‐related genes, properties of cancer stem cells (CSCs), and anti‐apoptosis was performed.ResultsLong‐term NNK exposure enhances migration and invasion with morphological alterations in a dose‐dependently manner. Furthermore, NNK exposure also upregulates Snail, promotes sphere‐forming ability, and overexpresses aldehyde dehydrogenase 1 (ALDH1), Nanog, OCT4, ABCG2, and MDR1.ConclusionThe current study confirmed that long‐term NNK exposure plays a role in HNSCC by increasing anti‐apoptosis and therapeutic resistance via the Snail‐RKIP signaling pathway. Our data also suggest that α7 nicotinic acetylcholine receptor (α7‐nAChR) inhibition or targeting Snail may provide a feasible rationale for preventing the progression of HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 37: 1712–1721, 2015
Incidence of hospitalization in patients with head and neck cancer treated with intensity‐modulated radiation therapy
Authors: Ling Diane C. , Kabolizadeh Peyman , Heron Dwight E. , Ohr James P. , Wang Hong , Johnson Jonas , Kubicek Gregory J. 
Published: July 2014

AbstractBackgroundPatients with primary head and neck cancer managed with radiation therapy (RT) +/‐ chemotherapy may experience significant treatment‐related toxicities. We assessed hospitalization as a metric for severe treatment‐related toxicities and evaluated patient and treatment factors for possible association.MethodsA retrospective review was performed on 147 patients with head and neck cancer treated with definitive or adjuvant intensity‐modulated radiation therapy (IMRT) +/‐ chemotherapy. Multiple Poisson regression model was used to analyze relationships between patient or treatment factors and number of hospital stays during RT and within 8 weeks after RT.ResultsMultivariate analysis showed preexisting diabetes or pulmonary disease, primary carcinoma of oral cavity, and prescribed radiation dose (p < .05) were associated with increased number of patient hospital stays during or shortly after RT.ConclusionWe found that 34.7% of patients experienced a chemoradiation toxicity‐related hospitalization during or shortly after treatment. Prior pulmonary disease, diabetes, and increasing prescribed radiation dose were associated with increased hospital stays. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1750–1755, 2015
Synergistic apoptosis in head and neck squamous cell carcinoma cells by co‐inhibition of insulin‐like growth factor‐1 receptor signaling and compensatory signaling pathways
Authors: Axelrod Mark J. , Mendez Rolando E. , Khalil Ashraf , Leimgruber Stephanie S. , Sharlow Elizabeth R. , Capaldo Brian , Conaway Mark , Gioeli Daniel G. , Weber Michael J. , Jameson Mark J. 
Published: July 2014

ABSTRACTBackgroundIn head and neck squamous cell carcinoma (HNSCC), resistance to single‐agent targeted therapy may be overcome by co‐targeting of compensatory signaling pathways.MethodsA targeted drug screen with 120 combinations was used on 9 HNSCC cell lines.ResultsMultiple novel drug combinations demonstrated synergistic growth inhibition. Combining the insulin‐like growth factor‐1 receptor (IGF‐1R) inhibitor, BMS754807, with either the human epidermal growth factor receptor (HER)‐family inhibitor, BMS599626, or the Src‐family kinase inhibitor, dasatinib, resulted in substantial synergy and growth inhibition. Depending on the cell line, these combinations induced synergistic or additive apoptosis; when synergistic apoptosis was observed, AKT phosphorylation was inhibited to a greater extent than either drug alone. Conversely, when additive apoptosis occurred, AKT phosphorylation was not reduced by the drug combination.ConclusionCombined IGF‐1R/HER family and IGF‐1R/Src family inhibition may have therapeutic potential in HNSCC. AKT may be a node of convergence between IGF‐1R signaling and pathways that compensate for IGF‐1R inhibition. © 2015 Wiley Periodicals, Inc. Head Neck 37: 1722–1732, 2015
Robotic thyroidectomy learning curve for beginning surgeons with little or no experience of endoscopic surgery
Authors: Park Jae Hyun , Lee Jandee , Hakim Nor Azham , Kim Ha Yan , Kang Sang‐Wook , Jeong Jong Ju , Nam Kee‐Hyun , Bae Keum‐Seok , Kang Seong Joon , Chung Woong Youn 
Published: July 2014

AbstractBackgroundThis study assessed the results of robotic thyroidectomy by fellowship‐trained surgeons in their initial independent practice, and whether standard fellowship training for robotic surgery shortens the learning curve.MethodsThis prospective cohort study evaluated outcomes in 125 patients who underwent robotic thyroidectomy using gasless transaxillary single‐incision technique by 2 recently graduated fellowship‐trained surgeons. Learning curves were analyzed by operation time, with proficiency defined as the point at which the slope of the time curve became less steep.ResultsOf the 125 patients, 113 underwent robotic less‐than‐total thyroidectomy, 9 underwent robotic total thyroidectomy and 3 underwent robotic total thyroidectomy with modified radical neck dissection. Mean total times for these 3 operations were 100.8 ± 20.6 minutes, 134.2 ± 38.7 minutes, and 284.7 ± 60.4 minutes, respectively. For both surgeons, the operation times gradually decreased, reaching a plateau after 20 robotic less‐than‐total thyroidectomies.ConclusionThe surgical learning curve for robotic thyroidectomy performed by recently graduated fellowship‐trained surgeons with little or no experience in endoscopic surgery showed excellent results compared with those in a large series of more experienced surgeons. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1705–1711, 2015
Myofascial pain syndrome after head and neck cancer treatment: Prevalence, risk factors, and influence on quality of life
Authors: Cardoso Leticia Rodrigues , Rizzo Cláudia Carvalho , de Oliveira Cleyton Zanardo , dos Santos Carlos Roberto , Carvalho André Lopes 
Published: July 2014

AbstractBackgroundPatients undergoing treatment for head and neck cancer may develop myofascial pain syndrome as sequelae. The purpose of this study was to determine the prevalence, risk factors, and quality of life (QOL) related to myofascial pain syndrome.MethodsThis was a prospective study including patients with head and neck cancer with at least a 1‐year disease‐free interval.ResultsOne hundred sixty‐seven patients were analyzed, and myofascial pain syndrome was diagnosed in 20 (11.9%). In the multivariate analysis, hypopharyngeal tumors (odds ratio [OR] = 6.35; 95% confidence interval [CI] = 1.58–25.56) and neck dissection (OR = 3.43; 95% CI = 1.16–10.17) were independent factors for myofascial pain syndrome. The pain (p < .001) and shoulder domain (p < .001) as well as overall University of Washington Quality of Life (UW‐QOL) score (p = .006) were significantly lower in the patients with myofascial pain syndrome.ConclusionMyofascial pain syndrome was observed in 1 of 9 patients after head and neck cancer treatment and a worse QOL was observed among them. Tumor site and neck dissection were found to be risk factors for myofascial pain syndrome. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1733–1737, 2015
Incidence of late‐onset pneumonia in patients after treatment with radiotherapy for nasopharyngeal carcinoma: A nationwide population‐based study
Authors: Yen Ting‐Ting , Lin Ching‐Heng , Jiang Rong‐San , Shih Yi‐Ting , Yen Hung‐Rong , Liang Kai‐Li 
Published: July 2014

ABSTRACTBackgroundThe purpose of this study was to assess the incidence of late‐onset pneumonia in patients with nasopharyngeal carcinoma (NPC) after radiotherapy.MethodsData were retrieved from the National Health Institute Research Database of Taiwan. We identified patients diagnosed with NPC (International Classification of Disease 9th revision‐Clinical Modification [ICD‐9‐CM] code 147) from January 2005 to December 2008 who received curative radiotherapy as the study cohort. Incidences of pneumonia and related sequelae after 90 days of radiotherapy were calculated.ResultsA total of 3814 patients were enrolled in this study and 210 (5.5%) had late‐onset pneumonia. The correlation coefficient between pneumonia and tube feeding was 0.332 (p < .001). The hazard ratio of pneumonia was 0.81 (95% confidence interval [CI] = 0.57–1.15) between patients with and without chemotherapy, and was 2.37 (95% CI = 1.73–3.24) between patients with and without re‐radiation.ConclusionLate‐onset pneumonia is not uncommon in patients with NPC after radiotherapy. The risks of associated sequelae and mortality cannot be ignored. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1756–1761, 2015
Establishment and characterization of an orthotopic sinonasal squamous cell carcinoma mouse model
Authors: Costales María , López Fernando , García–Inclán Cristina , Fernández Soledad , Marcos César Álvarez , Llorente José Luis , Hermsen Mario A. 
Published: July 2014

AbstractBackgroundDespite therapeutic improvements, patients with sinonasal squamous cell carcinoma (SCC) still face an unfavorable prognosis and there is great need for alternative treatments.MethodsSCCNC4 cells, originally derived from a T2N1M0 primary and untreated sinonasal SCC, were inoculated in the maxillary sinus of immunodeficient mice. Histology, invasive behavior, and genetic features were evaluated and compared with the original primary tumor.ResultsThe mice developed tumors that invaded bone, surrounding tissues, and brain, showing the same poor differentiation as the original primary tumor. Genetic analysis revealed an almost identical pattern of copy number alterations, except for the deletion and loss of expression of the genes CDKN2A and PTEN.ConclusionThis article shows the feasibility of an orthotopic mouse model of SCC of the maxillary sinus. Completed by genome‐wide genetic profiling data, this model will be useful for preclinical testing of specific gene‐targeted anticancer drugs. © 2014 Wiley Periodicals, Inc. Head Neck 37: 1769–1775, 2015
Investigating the Antecedents of Customer Behavioral Intentions Using the Service Acceptance Model
Authors: Pai Fan‐Yun , Yeh Tsu‐Ming 
Published: July 2014

AbstractIn highly competitive markets, enterprises provide various services to attract and retain customers. However, even though they are able provide higher‐quality services to customers, there are still many companies that are unable to gain benefits because customers do want these services. With the integration of the theory of planned behavior and quality‐value‐satisfaction‐behavioral intention model proposed by Cronin, Brandy, and Hult (), the service acceptance model, an extended model based on the characteristics of the service industry, is proposed in this work to investigate the effects of attitude, social pressure, perceived behavioral control, service quality, and service value on behavioral intention. The empirical results show that the perceived behavioral control of the high‐income sample group is not correlated with customer behavioral intentions, which differs from the results for the overall and low‐income sample groups. The customers’ own financial resources are thus of great importance in this context. Service quality has a significantly positive impact on perceived value and attitude. This suggests that good service quality will be conducive to increasing perceived value and strengthening customers’ positive attitudes toward a service, indirectly affecting the behavioral intention to purchase a service.
Fludarabine–Mitoxantrone–Rituximab regimen in untreated indolent non‐follicular non‐Hodgkin's lymphoma: experience on 143 patients
Authors: Zinzani Pier Luigi , Pellegrini Cinzia , Broccoli Alessandro , Gandolfi Letizia , Stefoni Vittorio , Casadei Beatrice , Maglie Roberto , Argnani Lisa , Pileri Stefano 
Published: July 2014

AbstractIndolent non‐follicular lymphomas (inFLs) are generally regarded as incurable, apart from extranodal mucosa‐associated lymphatic tissue lymphomas, which can be partially cured by surgery, local radiotherapy, or antibiotic treatment. The aim of the present study was to test the degree of effectiveness and the safety of the regimen containing fludarabine, mitoxantrone, and rituximab (FMR) in inFL patients considering all the different entities belonging to this group. An observational retrospective study was conducted on 143 inFL patients providing that their first chemoimmunotherapy performed was FMR regimen and diagnosis from September 2000 to March 2011. There were 32 small lymphocytic lymphomas and 111 marginal zone lymphomas. At the end of treatment, overall response rate was 96.5% with 88% of complete responses (CR) and 8.5% of partial responses. With a median follow‐up of 48 months, 10 out of 125 (8%) CR patients had disease relapse, yielding an estimated 9‐year disease‐free survival (DFS) of 74.9% and an estimated 10‐year overall survival of 92.8%. The estimated 9‐year progression free survival was 70.5%. The 10 relapsed patients showed lymphoma recurrence within 52 months: after this time, the DFS curve presented a plateau configuration. Only two (1.4%) patients developed a secondary hematological neoplasia. This study showed promising findings for the use of a fludarabine‐based regimen in combination with rituximab in the front‐line treatment of symptomatic inFL with a noteworthy high percentage of CR associated to an interesting long‐term DFS and favorable acute and long‐term safety profile. Copyright © 2014 John Wiley & Sons, Ltd.
Work Experiences of Foreign‐Born Asian Women Counseling and Psychology Faculty
Authors: Kim Eunha , Hogge Ingrid , Mok Geoffrey , Nishida Harumi 
Published: July 2014

Eleven foreign‐born and ‐raised Asian women faculty in counseling and psychology programs in the United States were interviewed about their work experiences. Analysis using consensual qualitative research revealed 7 sources of stressors, 6 emotional reactions associated with stressors, 5 coping strategies, and 4 types of intrinsic rewards gained from encountering challenges. The results of the study provide information about the unique experiences of this understudied group and have implications for the U.S. higher education system.Se entrevistó a once profesoras universitarias asiáticas de programas de consejería y psicología en Estados Unidos nacidas y criadas en el extranjero acerca de sus experiencias de trabajo. Un análisis basado en investigación cualitativa consensuada reveló 7 fuentes de estrés, 6 reacciones emocionales asociadas a los motivos del estrés, 5 estrategias de afrontamiento y 4 tipos de recompensa intrínseca ganada por afrontar los desafíos. Los resultados del estudio proporcionan información sobre las experiencias únicas de este grupo que no ha sido estudiado suficientemente, y tienen implicaciones para el sistema de educación superior en Estados Unidos.
Pleiotropic Effects of Obesity on Fracture Risk: The Study of Women's Health Across the Nation
Authors: Ishii Shinya , Cauley Jane A , Greendale Gail A , Nielsen Carrie , Karvonen-Gutierrez Carrie , Ruppert Kristine , Karlamangla Arun S 
Published: July 2014

ABSTRACT

Some aspects of an obese body habitus may protect against fracture risk (higher bone mineral density [BMD] and greater tissue padding), while others may augment that risk (greater impact forces during a fall). To examine these competing pathways, we analyzed data from a multisite, multiethnic cohort of 1924 women, premenopausal or early perimenopausal at baseline. Obesity was defined as baseline body mass index (BMI) &gt; 30 kg/m2. Composite indices of femoral neck strength relative to fall impact forces were constructed from DXA-derived bone size, BMD and body size. Incident fractures were ascertained annually during a median follow-up of 9 years. In multivariable linear regression adjusted for covariates, higher BMI was associated with higher BMD but with lower composite strength indices, suggesting that although BMD increases with greater skeletal loading, the increase is not sufficient to compensate for the increase in fall impact forces. During the follow-up, 201 women had fractures. In Cox proportional hazard analyses, obesity was associated with increased fracture hazard adjusted for BMD, consistent with greater fall impact forces in obese individuals. Adjusted for composite indices of femoral neck strength relative to fall impact forces, obesity was associated with decreased fracture hazard, consistent with a protective effect of soft tissue padding. Further adjustment for hip circumference, a surrogate marker of soft tissue padding, attenuated the obesity–fracture association. Our findings support that there are at least three major mechanisms by which obesity influences fracture risk: increased BMD in response to greater skeletal loading, increased impact forces, and greater absorption of impact forces by soft tissue padding. © 2014 American Society for Bone and Mineral Research.
First‐in‐human study of the safety, tolerability, pharmacokinetics and pharmacodynamics of abediterol (LAS100977), a novel long‐acting Β2‐agonist
Authors: Timmer Wolfgang , Massana Eric , Jimenez Eulalia , Seoane Beatriz , de Miquel Gonzalo , Ruiz Sandrine 
Published: July 2014

AbstractHere we report the results of a first‐in‐human study to evaluate the safety, tolerability pharmacokinetics, and pharmacodynamics of abediterol, a new β2‐adrenergic agonist. Forty‐eight healthy males aged 18–45 years received abediterol doses of 5, 10, 25, or 50 µg, or placebo. Safety and tolerability assessments included adverse event reporting, pulse and blood pressure monitoring, 12‐lead electrocardiograms, laboratory tests, and physical examination. Pharmacodynamic assessments included whole body plethysmography to determine the bronchodilatory effect by means of airway conductance and resistance. Blood and urine samples were obtained for pharmacokinetic analyses. Abediterol showed an overall good safety and tolerability profile in the dose range tested, consistent with the expected characteristics of a β2‐adrenergic agonist. A dose‐dependent increase of systemic treatment‐emergent adverse events was observed, the most frequent being palpitations, tremor, nausea, and asthenia; most were mild in intensity and resolved without the need for intervention. Improvements in airway conductance (increase) and resistance (decrease) were greater for all doses of abediterol tested compared with placebo at all time‐points up to 36 hours. This first‐in‐human study suggests a potent, rapid, and sustained bronchodilatory effect of abediterol in healthy male subjects. Lower doses are currently under investigation in patients with asthma and in patients with COPD.