bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neonatal lipopolysaccharide treatment has long‐term effects on monoaminergic and cannabinoid receptors in the rat
Authors: Zavitsanou Katerina , Dalton Victoria S. , Walker Adam K. , Weickert Cynthia S. , Sominsky Luba , Hodgson Deborah M. 
Published: February 2013

ABSTRACTBrain inflammation in early life has been proposed to play important roles in the development of anxiety and psychosis‐related behaviors in adulthood, behaviors that rely on the integrity of dopamine and/or serotonin systems. Moreover recent behavioral and anatomical evidence suggests involvement of CB1 receptors in the control of emotion and mood. In this study, we determined the effects of neonatal LPS treatment on dopamine, serotonin, and cannabinoid receptor binding in adulthood. Rats were treated with the bacterial endotoxin lipopolysaccharide (LPS) on postnatal day (PND) 3 and 5. Dopamine D1, D2, serotonin 5HT1A, 5HT2A, and serotonin transporter and cannabinoid CB1 receptor binding across several brain regions were measured autoradiographically in adulthood (PND 85). Neonatal LPS treatment caused a significant increase in dopamine D2 in the nucleus accumbens and olfactory tubercle, a decrease in 5HT1A receptor binding in the hippocampus CA1 and ventromedial hypothalamus. A decrease in CB1 receptor binding after neonatal LPS was observed in the amygdala. Neonatal LPS had no significant impact on dopamine D1, serotonin 5HT2A or serotonin transporter binding in any of the brain regions examined. Our results suggest long lasting, region specific effects and differential impact on dopamine, serotonin and cannabinoid receptor systems following neonatal inflammation, that may form the basis for compromised anxiety and psychosis related behaviors. Synapse, 2013. © 2013 Wiley Periodicals, Inc.
Direct comparison of [18F]MH.MZ and [18F]altanserin for 5‐HT2A receptor imaging with PET
Authors: Hansen Hanne D. , Ettrup Anders , Herth Matthias M. , Dyssegaard Agnete , Ratner Cecilia , Gillings Nic , Knudsen Gitte M. 
Published: February 2013

ABSTRACTImaging the cerebral serotonin 2A (5‐HT2A) receptors with positron emission tomography (PET) has been carried out in humans with [11C]MDL 100907 and [18F]altanserin. Recently, the MDL 100907 analogue [18F]MH.MZ was developed combining the selectivity profile of MDL 100907 and the favourable radiophysical properties of fluorine‐18. Here, we present a direct comparison of [18F]altanserin and [18F]MH.MZ. 5‐HT2A receptor binding in pig cortex and cerebellum was investigated by autoradiography with [3H]MDL 100907, [18F]MH.MZ, and [18F]altanserin. [18F]MH.MZ and [18F]altanserin were investigated in Danish Landrace pigs by brain PET scanning at baseline and after i.v. administration of blocking doses of ketanserin. Full arterial input function and high performance liquid chromatography (HPLC) analysis allowed for tissue‐compartment kinetic modeling of PET data. In vitro autoradiography showed high binding in cortical regions with both [18F]MH.MZ and [18F]altanserin. Significant 5‐HT2A receptor binding was also found in the pig cerebellum, thus making this region unsuitable as a reference region for in vivo data analysis in this species. The cortical binding of [18F]MH.MZ and [18F]altanserin was blocked by ketanserin supporting that both radioligands bind to 5‐HT2A receptors in the pig brain. In the HPLC analysis of pig plasma, [18F]MH.MZ displayed a fast and reproducible metabolism resulting in hydrophilic radiometabolites only whereas the metabolic profile of [18F]altanserin as expected showed lipophilic radiometabolites. Due to the slow kinetics of [18F]MH.MZ in high‐binding regions in vivo, we suggest that [18F]MH.MZ will be an appropriate tracer for low binding regions where kinetics will be faster, whereas [18F]altanserin is a suitable tracer for high‐binding regions. Synapse, 2013. © 2013 Wiley Periodicals, Inc.
Analysis of light detection and ranging wind speed measurements for wind turbine control
Authors: Simley Eric , Pao Lucy Y. , Frehlich Rod , Jonkman Bonnie , Kelley Neil 
Published: February 2013

ABSTRACTLight detection and ranging (LIDAR) systems are able to measure the speed of incoming wind before it reaches a wind turbine rotor. These preview wind measurements can be used in feedforward control systems designed to reduce turbine structural loads. However, the degree to which such preview‐based control techniques can reduce loads by reacting to turbulence depends on how accurately the incoming wind field can be measured. This study examines the accuracy of different measurement scenarios that rely on coherent continuous‐wave or pulsed Doppler LIDAR systems, in terms of root‐mean‐square measurement error, to determine their applicability to feedforward control. In particular, the impacts of measurement range, angular offset of the LIDAR beam from the wind direction, and measurement noise are studied for various wind conditions. A realistic simulation case involving a scanning LIDAR unit mounted in the spinner of a MW‐scale wind turbine is studied in depth, with emphasis on preview distances that provide minimum measurement error for a specific scan radius. Measurement error is analyzed for LIDAR‐based estimates of point wind speeds at the rotor as well as spanwise averaged blade effective wind speeds. The impact of turbulence structures with high coherent turbulent kinetic energy on measurement error is discussed as well. Copyright © 2013 John Wiley & Sons, Ltd.
A practical approach to fracture analysis at the trailing edge of wind turbine rotor blades
Authors: Eder M.A. , Bitsche R.D. , Nielsen M. , Branner K. 
Published: February 2013

ABSTRACTWind turbine rotor blades are commonly manufactured from composite materials by a moulding process. Typically, the wind turbine blade is produced in two halves, which are eventually adhesively joined along their edges. Investigations of operating wind turbine blades show that debonding of the trailing edge joint is a common failure type, and information on specific reasons is scarce. This paper is concerned with the estimation of the strain energy release rates (SERRs) in trailing edges of wind turbine blades in order to gain insight into the driving failure mechanisms. A method based on the virtual crack closure technique (VCCT) is proposed, which can be used to identify critical areas in the adhesive joint of a trailing edge. The paper gives an overview of methods applicable for fracture cases comprising non‐parallel crack faces in the realm of linear fracture mechanics. Furthermore, the VCCT is discussed in detail and validated against numerical analyses in 2D and 3D. Finally, the SERR of a typical blade section subjected to various loading conditions is investigated and assessed in order to identify potential design drivers for trailing edge details. Analysis of the blade section model suggests that mode III action is governing and accordingly that flapwise shear and torsion are the most important load cases.Copyright © 2013 John Wiley & Sons, Ltd.
Effective and accurate approaches for wind turbine gearbox condition monitoring
Authors: Luo Huageng , Hatch Charles , Kalb Matthew , Hanna Jesse , Weiss Adam , Sheng Shuangwen 
Published: February 2013

ABSTRACTThis paper presents effective and accurate approaches in vibration‐based wind turbine drivetrain component condition monitoring. Detailed spectral analysis and acceleration enveloping techniques were used to effectively extract the gear and bearing damage features. Synchronous analysis was used to accurately detect specific damage features during constantly varying operational conditions. A typical wind turbine gearbox amplifies shaft speed two orders of magnitude from the rotor to the generator. To account for all necessary vibration signatures, synchronous sampling must be carried out for multiple revolutions and at a relatively high rate. The synchronous sampling used in this paper was carried out in the digital domain after both the keyphasor and the vibration signals were digitized at high sampling rate and high sampling resolution analog‐to‐digital conversion. Sometimes, the shaft speed is provided in a speed time history format, as in the case of the National Renewable Energy Laboratory (NREL) Round Robin project. To carry out synchronous sampling using the speed time history, a unique synthesized synchronous sampling technique was adopted. The approach presented in this paper was realized using MATLAB (MathWorks, Natick, MA) codes and then validated with a wind turbine field case. It was also applied to the NREL wind turbine drivetrain condition monitoring Round Robin project. The identified damage results using the techniques discussed were compared with post‐test inspection results with good correlation. Copyright © 2013 John Wiley & Sons, Ltd.
Two Metal Complexes Based on the Ligand 3, 4‐Pyrazoledi­carboxylic Acid: Synthesis, Structures, and Luminescent ­Properties
Authors: Chen Linti , Tao Feng , Wang Lidong , Hong Jian , Jia Xiaoyan , Bao Jinting , Ji Yunzhou , Cheng Meiling , Liu Qi 
Published: February 2013

AbstractTwo new metal complexes, {[Cd2(μ2‐H2pdc)2(H2O)8]·[Cd2(H2pdc)4(H2O)2(μ2‐Cl)2]}·2H2O (1), and [Ba2(H2pdc)4(H2O)8]·2H2O (2) (H3pdc = 3, 4‐pyrazoledicarboxylic acid), were synthesized and characterized by elemental analysis, IR spectroscopy, and single‐crystal X‐ray diffraction. The crystal structures show that compound 1 is an independent unit consisting of two discrete dinuclear complex ions [Cd2(μ2‐H2pdc)2(H2O)8]2+ cation and [Cd2(H2pdc)4(H2O)2(μ2‐Cl)2]2– anion, and the two kinds of ions are linked by hydrogen bonds and electrostatic interactions to generate a 3D supramolecular network. Complex 2 is a common dinuclear structure, which is further assembled to a 3D supramolecular network through intermolecular hydrogen bonds and π–π stacks. The hydrogen bonding interactions involving lattice water or coordinated water molecules all exist in complexes 1 and 2. Notably, three coordination modes of 3, 4‐pyrazoledicarboxylic acid were observed. The thermal and photoluminescent properties of complexes 1 and 2 in the solid state were also investigated.
Structured Synchronous Implementation of an Enhanced Recovery Program in Elective Colonic Surgery in 33 Hospitals in The Netherlands
Authors: Gillissen Freek , Hoff Christiaan , Maessen José M. C. , Winkens Bjorn , Teeuwen Jitske H. F. A. , von Meyenfeldt Maarten F. , Dejong Cornelis H. C. 
Published: February 2013

AbstractBackgroundIt has been clearly shown that after elective colorectal surgery patients benefit from multimodal perioperative care programs. The Dutch Institute for Health Care Improvement started a breakthrough project to implement a multimodal perioperative care program of enhanced recovery after surgery (ERAS). This pre/post noncontrolled study evaluated the success of large‐scale implementation of the ERAS program for elective colonic surgery using the breakthrough series.MethodsA total of 33 hospitals participated in this breakthrough project during 2005–2009. Each hospital performed a retrospective chart review to gather information on traditionally treated patients (pre‐ERAS group, n = 1,451). During the subsequent year patients were treated according to the ERAS program (ERAS group, n = 1 034). Outcomes were length of stay (LOS), functional recovery, adherence to the protocol, and determinants of reduced LOS.ResultsMedian LOS decreased significantly from 9 to 6 days (p < 0.001). In the ERAS group, functional recovery was reached within 3 days. Adherence to the protocol elements was high during the preoperative and perioperative phases but slightly lower during the postoperative phase. Younger age, female sex, American Society of Anesthesiologists grades I/II, and laparoscopic surgery were associated with decreased LOS. Care elements that positively influenced LOS were cessation of intravenous fluids and mobilization on postoperative day 1 and administration of laxatives postoperatively.ConclusionsThe ERAS program was successfully implemented in one‐third of all Dutch hospitals using the breakthrough series. Participating hospitals reduced the LOS by a median 3 days and were able to improve their standard of care in elective colonic surgery.
The new 2012 German recommendations for treating rheumatoid arthritis
Authors: Wollenhaupt J. , Albrecht K. , Krüger K. , Müller-Ladner U. 
Published: February 2013

Abstract
The German Society for Rheumatology recently published guidelines for the sequential therapy of rheumatoid arthritis (RA). These recommendations were developed as a transition from the 2010 EULAR (EUropean League Against Rheumatism) recommendations to the national clinical practice and are based on an updated systematic literature research and expert discussion. While most EULAR recommendations have remained unchanged, some were modified based on new evidence from randomized, controlled trials, current clinical practice, or national drug approval status. The guidelines also include a treatment algorithm for sequential therapy of RA with disease-modifying agents including biologics.
IL28B polymorphisms predict the virological response to standard therapy in patients with chronic hepatitis C virus genotype 4 infection
Authors: Abdo Ayman A. , Al-Ahdal Mohammed N. , Khalid Saira S. , Helmy Ahmed , Sanai Faisal M. , Alswat Khalid , Al-hamoudi Waleed , Ali Safiyya M. , Al-Ashgar Hamad I. , Al-Mdani Abdallah , Albenmousa Ali , Al Faleh Faleh Z. , Al-Anazi Mashael , Khalaf Nisreen , Al-Qahtani Ahmed 
Published: February 2013

Abstract

Background
Genome-wide association studies have recently revealed that several single-nucleotide polymorphisms (SNPs) in the interleukin (IL) 28B genes can predict the sustained virological response (SVR) to pegylated interferon-α2a/b plus ribavirin in hepatitis C virus (HCV)-genotype 1 patients. However, data for patients infected with HCV genotype 4 (HCV-G4) are limited.

Aim
We analyzed the association of IL28B SNPs (hematological, biochemical, virological, and pathological factors) with SVR in the HCV-G4 monoinfected cohort of patients.

Patients and methods
One hundred twenty-nine treatment-naïve HCV-G4 patients undergoing treatment were recruited from three tertiary care centers in Saudi Arabia. Five IL28B SNPs (rs12979860, rs12980275, rs8105790, rs8099917, and rs72486680) were identified by polymerase chain reaction and DNA sequencing. SVR was statistically correlated with various clinical, histopathological, virological, and genetic parameters.

Results
SVR was significantly associated with the CC and AA alleles of rs12979860 (p = 0.008) and rs12980275 (p = 0.004), respectively. Moreover, albumin levels (p = 0.002) and platelet count (p = 0.039) showed significant differences in the SVR and No SVR groups. On multivariate analysis, the CC allele of rs12979860 (OR, 2.89; 95 % CI 1.6–6.2, p = 0.006) and albumin levels (OR, 1.2; 95 % CI 1.1–1.4, p = 0.001) independently predicted SVR.

Conclusions
IL28B polymorphism (CC allele of rs12979860) predicts the sustained response to antiviral therapy in HCV-G4.
An Efficient Approach to Obtaining Large Numbers of Distant Supernova Host Galaxy Redshifts
Authors: Lidman C. , Ruhlmann-Kleider V. , Sullivan M. , Myzska J. , Dobbie P. , Glazebrook K. , Mould J. , Astier P. , Balland C. , Betoule M. , Carlberg R. , Conley A. , Fouchez D. , Guy J. , Hardin D. , Hook I. , Howell D. A. , Pain R. , Palanque-Delabrouille N. , Perrett K. , Pritchet C. , Regnault N. , Rich J. 
Published: February 2013

AbstractWe use the wide-field capabilities of the 2 degree field fibre positioner and the AAOmega spectrograph on the Anglo-Australian Telescope (AAT) to obtain redshifts of galaxies that hosted supernovae during the first 3 years of the Supernova Legacy Survey (SNLS). With exposure times ranging from 10 to 60 ks per galaxy, we were able to obtain redshifts for 400 host galaxies in two SNLS fields, thereby substantially increasing the total number of SNLS supernovae with host galaxy redshifts. The median redshift of the galaxies in our sample that hosted photometrically classified Type Ia supernovae (SNe Ia) is z ~ 0.77, which is 25% higher than the median redshift of spectroscopically confirmed SNe Ia in the 3-year sample of the SNLS. Our results demonstrate that one can use wide-field fibre-fed multi-object spectrographs on 4-m telescopes to efficiently obtain redshifts for large numbers of supernova host galaxies over the large areas of the sky that will be covered by future high-redshift supernova surveys, such as the Dark Energy Survey.
GASKAP—The Galactic ASKAP Survey
Authors: Dickey John M. , McClure-Griffiths Naomi , Gibson Steven J. , Gómez José F. , Imai Hiroshi , Jones Paul , Stanimirović Snežana , Van Loon Jacco Th. , Walsh Andrew , Alberdi A. , Anglada G. , Uscanga L. , Arce H. , Bailey M. , Begum A. , Wakker B. , Bekhti N. Ben , Kalberla P. , Winkel B. , Bekki K. , For B.-Q. , Staveley-Smith L. , Westmeier T. , Burton M. , Cunningham M. , Dawson J. , Ellingsen S. , Diamond P. , Green J. A. , Hill A. S. , Koribalski B. , McConnell D. , Rathborne J. , Voronkov M. , Douglas K. A. , English J. , Ford H. Alyson , Lockman F. J. , Foster T. , Gomez Y. , Green A. , Bland-Hawthorn J. , Gulyaev S. , Hoare M. , Joncas G. , Kang J.-H. , Kerton C. R. , Koo B.-C. , Leahy D. , Lo N. , Migenes V. , Nakashima J. , Zhang Y. , Nidever D. , Peek J. E. G. , Tafoya D. , Tian W. , Wu D. 
Published: February 2013

AbstractA survey of the Milky Way disk and the Magellanic System at the wavelengths of the 21-cm atomic hydrogen (H i) line and three 18-cm lines of the OH molecule will be carried out with the Australian Square Kilometre Array Pathfinder telescope. The survey will study the distribution of H i emission and absorption with unprecedented angular and velocity resolution, as well as molecular line thermal emission, absorption, and maser lines. The area to be covered includes the Galactic plane (|b| < 10°) at all declinations south of δ = +40°, spanning longitudes 167° through 360°to 79° at b = 0°, plus the entire area of the Magellanic Stream and Clouds, a total of 13 020 deg2. The brightness temperature sensitivity will be very good, typically σT≃ 1 K at resolution 30 arcsec and 1 km s−1. The survey has a wide spectrum of scientific goals, from studies of galaxy evolution to star formation, with particular contributions to understanding stellar wind kinematics, the thermal phases of the interstellar medium, the interaction between gas in the disk and halo, and the dynamical and thermal states of gas at various positions along the Magellanic Stream.
Optical Corrections to the Véron-Cetty and Véron Quasar Catalogue
Authors: Flesch E. 
Published: February 2013

AbstractFixes are presented to be applied to the Véron-Cetty and Véron Quasar Catalogue, 13th edition. These are comprised of 39 de-duplications, 380 astrometric moves of 8 + arcsec of which 31 are over 10 arcmin, and 30 indicated de-listings.
Absolute Magnitude Calibration for Giants Based on the Colour–Magnitude Diagrams of Galactic Clusters. II. Calibration with SDSS
Authors: Karaali S. , Bilir S. , Gökçe E. Yaz 
Published: February 2013

AbstractWe present an absolute magnitude calibration for red giants with the colour–magnitude diagrams of six Galactic clusters with different metallicities, i.e. M92, M13, M3, M71, NGC 6791, and NGC 2158. The combination of the absolute magnitudes of the red giant sequences with the corresponding metallicities provides calibration for absolute magnitude estimation for red giants for a given (g − r)0 colour. The calibration is defined in the colour interval 0.45 ≤ (g − r)0 ≤ 1.30 mag and it covers the metallicity interval −2.15≤[Fe/H]≤ +0.37 dex. The absolute magnitude residuals obtained by the application of the procedure to another set of Galactic clusters lie in the interval −0.28 < ΔM ≤ +0.43 mag. However, the range of 94% of the residuals is shorter, −0.1 < ΔM ≤ +0.4 mag. The mean and the standard deviation of (all) residuals are 0.169 and 0.140 mag, respectively. The derived relations are applicable to stars older than 2 Gyr, the age of the youngest calibrating cluster.
Absolute Magnitude Calibration for Red Giants Based on the Colour–Magnitude Diagrams of Galactic Clusters. III. Calibration with 2MASS
Authors: Karaali S. , Bilir S. , Gökçe E. Yaz 
Published: February 2013

AbstractWe present two absolute magnitude calibrations, MJ and MKs, for red giants with the colour–magnitude diagrams of five Galactic clusters with different metallicities, i.e. M92, M13, M71, M67, and NGC 6791. The combination of the absolute magnitudes of the red giant sequences with the corresponding metallicities provides calibration for absolute magnitude estimation for red giants for a given colour. The calibrations for MJ and MKs are defined in the colour intervals 1.3≤(V−J)0≤2.8 and 1.75≤(V−Ks)0≤3.80 mag, respectively, and they cover the metallicity interval −2.15≤[Fe/H]≤+0.37 dex. The absolute magnitude residuals obtained by the application of the procedure to another set of Galactic clusters lie in the intervals −0.08<ΔMJ≤+0.34 and -0.10< Δ MKs≤ +0.27 mag for MJ and MKs, respectively. The means and standard deviations of the residuals are 〈ΔMJ〉=0.137 and σMJ=0.080, and $〈 Δ MKs〉 =0.109 and σMKs=0.123 mag. The derived relations are applicable to stars older than 4 Gyr, the age of the youngest calibrating cluster.
Study of the Abundance Patterns in the Metal-Poor Stellar Stream
Authors: Li Hongjie , Liang Shuai , Cui Wenyuan , Zhang Bo 
Published: February 2013

AbstractThe chemical abundances of the metal-poor stars in the stellar stream provide important information for setting constraints on models of neutron-capture processes. The study of these stars could gives us a better understanding of the r-process nucleosynthesis and chemical composition of the early Galaxy. Using the updated main r-process and weak r-process patterns, we fit abundances in the stellar stream stars. The weak r-process component coefficients are almost constant for the sample stars, including r-rich stars, which means that both the weak r-process and Fe are produced as primary elements from Type II supernovae and their yields have nearly a constant mass fraction. The difference between the stream stars and r-rich stars is obvious. For the stream stars, the fact that the increased trend in the main r-process component coefficients as metallicity increases means a gradual increase in the production of main r-process elements relative to iron. This behaviour implies that the masses of progenitors for the main r-process are smaller than those of the weak r-process. Furthermore, we find that the metal-poor stream star HD 237846 is a weak r-process star.