bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suitability of cyclic voltammetry for the measurement of sodium borohydride (NaBH4) in a solution of Cr(VI)/organic compounds/NaBH4
Authors: Njoya Ousmanou , Pam Seidou , Oyono Joseph Sadrack Ondoua 
Published: July 2024

ABSTRACT

Cr(VI) reduction by NaBH4 enhanced by organic compounds has been proven to be an effective method. The effort for optimized and efficient application of the method was the reason for the determination of residual NaBH4 in the Cr(VI)/organic compounds/NaBH4 reduction system for reducing agent dosage efficiency. This work showed a suitable detection of NaBH4 standard samples using Pt and Au as working electrode, respectively, and graphite rod as an auxiliary electrode and Ag/AgCl as a reference electrode. In the presence of organic compounds (acetate, citrate, and EDTA), interference was observed in the NaBH4 measurement on Pt electrode making it an unsuitable method for NaBH4 measurement in the presence of organic compounds. As the Au plate electrode was used as a working electrode, NaBH4 solutions measurement in the presence of organic compounds (acetate, citrate and EDTA) by peaks at −0.55 V was found to be affected by the coexisting organic compounds. However, no significant interference of the aforementioned organic compounds was observed at the −0.27 V peak values. The presence of Cr(VI) coexisting with NaBH4 was found to interfere with the NaBH4 measurement using both working electrodes, with a strong correlation between Cr(VI) concentration and the peak values obtained at 0.27 V of Au electrode.
Coupled treatment of aniline and phenol in water by electrochemical copolymerization
Authors: Li Xiuyun , Tian Yue , Di Hongxiang , Yang Wenzhong , Wang Yahui , Tian Lifang 
Published: July 2024

ABSTRACT

Anilines and phenols are recognized as challenging organic pollutants in industrial wastewater. Herein, the coupled treatment of aniline and phenol in water was achieved through electrochemical oxidation-induced copolymerization. After the electrolysis (1,300 mA for 10 h) in the solution of aniline and phenol (200 mL, each at a concentration of 5 g/L), the organic compounds were efficiently precipitated from their mixed solution by copolymerization. These insoluble copolymers could be easily separated by filtration and collected as brown powders, and the average removal rate of aniline and phenol was calculated as 0.6 mol/h m2 in this coupled electrolysis. The chemical oxygen demand (COD) test of the filtrates showed that it reached up to 98% of the COD removal ratio. Moreover, mixed solutions containing multiple aniline and phenol derivatives were also applicable for this coupled treatment strategy, and they were efficiently removed together after electrolysis.
Intelligent Systems based on Cyclodextrins for the Treatment of Breast Cancer
Authors: Nunes Adenia Mirela Alves , de Oliveira Alves Júnior José , Haydée Valéria Springer , Júnior João Augusto Oshiro 
Published: July 2024

:
The incidence of breast cancer has been increasing over the last four decades, although the mortality
rate has decreased. Endocrine therapy and chemotherapy are the most used options for cancer treatment but
several obstacles are still attributed to these therapies. Smart materials, such as nanocarriers for targeting, delivery
and release of active ingredients, sensitive to intrinsic-stimuli (pH-responsive, redox-responsive, enzyme-
responsive, and thermo-responsive) and extrinsic-stimuli (ultrasound-responsive, magnetic-responsive,
light-responsive) have been studied as a novel strategy in breast cancer therapy. Cyclodextrins (CDs) are used
in the design of these stimuli-responsive drug carrier and delivery systems, either through inclusion complexes
with hydrophobic molecules or covalent bonds with large structures to generate new materials. The present
work aims to gather and integrate recent data from in vitro and in vivo preclinical studies of CD-based stimuli-
responsive systems to contribute to the research in treating breast cancer. All drug carriers showed high in
vitro release rates in the presence of a stimulus. The stimuli-responsive nanoplatforms presented biocompatibility
and satisfactory results of IC50, inhibition of cell viability and antitumor activity against several breast cancer
cell lines. Additionally, these systems led to a significant reduction in drug dosages, which encouraged possible
clinical studies for better alternatives to traditional antitumor therapies.
Resistance Distance and Kirchhoff Index in Windmill Graphs
Authors: Sardar Muhammad Shoaib , Xu Shou-Jun 
Published: July 2024

Introduction:
The objective of this study is to compute the Kirchhoff index and re-sistance distance for two classes of windmill graphs, namely the French windmill graph and the Dutch windmill graph.

Methods:
In this study, G is considered a simple connected graph with vertex set V (G) and edge set E(G). N is supposed to represent a network derived from G by substituting a 1-ohm resistor for each edge of G. In that case, the resistance between μ,ν ∈ V (G) is considered analogous to the resistance between two equivalent nodes in network N.

Results:
The Kirchhoff index of G is the sum of the resistance distances between all pairs of vertices in G.

Conclusion:
In addition, the Kirchhoff index and resistance distance are computed in this study for specific generalizations of these graphs.
Synthesis, Spectroscopic Characterization and Study of Antibacterial
Potency, Antioxidant Scavenging and in-vitro Anti-inflammatory
Properties of Pyrimidine-based Schiff Bases
Authors: Kale Vinod , Zangade Sainath , Bhopalkar Gangadhar 
Published: July 2024

Background::
As per the literature survey, the pyrimidine-based molecules display
prominent antibacterial, anti-inflammatory, antioxidant, anticancer, analgesic, anticonvulsant,
anti-tubercular and antimalarial properties. The biological relevance of pyrimidine-based pharmacophore
structures encourages us to synthesize some novel imines derived from 2-amino pyrimidine
and substituted benzaldehydes.

Objective::
The present communication describes the synthesis of six imines 3a-f derived from 2-
aminopyrimidine. The tri-potassium phosphate catalyst used in the current study optimizes the
microwave-assisted synthesis of these novel Schiff bases. The reported method for the synthesis
of imines is found to be eco-friendly in terms of the effective use of catalyst Al2O3-K3PO4 with
microwave in the synthesis of pyrimidine-based Schiff bases.

Methods::
Different spectroscopic methods, such as 1H NMR, IR, GCMS and elemental analysis,
were used to determine the structure of all synthesized Schiff bases. Further, the imines 3a-f
were screened for antibacterial properties to check their inhibitory potency against E. coli and
S. aureus.

Results::
The biological potency of imines 3a-f was also studied for their antioxidant and in-vitro
anti-inflammatory activity. The obtained results reveal that Schiff base 3c showed potent antiinflammatory
activity with a 31.538% ± 2.055 inhibition of inflammation. Moreover, the synthesized
imines 3a-f have been screened and studied for their antioxidant activity by DPPH and nitric
oxide radical scavengers. Some of these, like 3c, show 15.98 ± 2.64 potency to scavenge
DPPH radicals as compared to standard. In the antimicrobial investigation, most of the Schiff bases
showed good inhibitory activity against various tested pathogens. The current study, therefore,
contributes to investigate a new class of imines with structurally modified anti-inflammatory
and antioxidant drugs.

Conclusion::
The outcome of the study revealed that compound 3c showed promising antiinflammatory
activity with 31.538 ± 2.055 inhibition of inflammation. All imines display antibacterial
potency in compounds 3a, 3b, 3c, and 3f. The antibacterial properties of these imines are
attributed to -OCH3, -OH and -Br as primary bioactive substituents present in the moiety of
imines, which enhance inhibitory properties against tested pathogens. The antioxidant scavenging
activity of imines indicates that compounds 3a, 3c, 3d, and 3f represent better anti-oxidants as
DPPH scavengers than standard ascorbic acid.
Glass Ionomer-Carboxymethyl Chitosan Cement: Setting Time, Microhardness, Mineral Phase, Crystallinity, and Dentin Remineralization Potential
Authors: Putranto Aditya Wisnu , Riska Grace , Kusumasari Citra , Margono Anggraini , Yanti Ermi 
Published: July 2024

Background
The application of Glass Ionomer Cement (GIC) stimulates dentin remineralization. Carboxymethyl-Chitosan (CMC) can stabilize Amorphous Calcium Phosphate (ACP) nanoclusters that promote intrafibrillar remineralization. However, the effect of modifying GIC with CMC in dentin remineralization has not been widely reported.

Objective
This study aims to determine how supplementing GIC material with CMC affects its setting time and crystallinity and evaluate how applying 5% and 10% GIC-CMC to demineralized dentin affects the dentin’s microhardness, mineral phase, and degree of crystallinity.

Methods
GIC was mixed with CMC at 5% and 10% ratios to produce GIC-CMC5% and GIC-CMC10%. GIC, GIC-CMC5%, and GIC-CMC10% were applied to acrylic molds. Their setting times and crystallinity were tested using the Vicat needle test and X-Ray Diffraction (XRD), respectively. The dentin samples were made into cavities, demineralized, and treated with GIC, GIC-CMC5%, and GIC-CMC10%. The tooth roots were soaked in phosphate-buffered saline for 14 days. Remineralization in the dentin was evaluated based on microhardness values using the Vickers test, and its mineral phase and degree of crystallinity were assessed using XRD.

Results
GIC-CMC (5% and 10%) had shorter setting times than the GIC but the same crystallinity. The microhardness of the treated dentin in the GIC-CMC5% and GIC-CMC10% groups increased compared to the GIC group. Hydroxyapatite crystals formed in the GIC and GIC-CMC samples, with the highest crystallinity in the GIC-CMC10% sample.

Conclusion
GIC-CMC had a shorter setting time than GIC but the same crystallinity. Applying GIC-CMC10% to demineralized dentin increased the dentin’s microhardness and crystallinity and promoted hydroxyapatite crystal mineral formation.
Capturing Home Care Information Management and Communication Processes Among Caregivers of Older Adults: Qualitative Study to Inform Technology Design
Authors: Tennant Ryan , Allana Sana , Mercer Kate , Burns Catherine M 
Published: July 2024

Background
The demand for complex home care is increasing with the growing aging population and the ongoing COVID-19 pandemic. Family and hired caregivers play a critical role in providing care for individuals with complex home care needs. However, there are significant gaps in research informing the design of complex home care technologies that consider the experiences of family and hired caregivers collectively.

Objective
The objective of this study was to explore the health documentation and communication experiences of family and hired caregivers to inform the design and adoption of new technologies for complex home care.

Methods
The research involved semistructured interviews with 15 caregivers, including family and hired caregivers, each of whom was caring for an older adult with complex medical needs in their home in Ontario, Canada. Due to COVID-19–related protection measures, the interviews were conducted via Teams (Microsoft Corp). The interview guide was informed by the cognitive work analysis framework, and the interview was conducted using storytelling principles of narrative medicine to enhance knowledge. Inductive thematic analysis was used to code the data and develop themes.

Results
Three main themes were developed. The first theme described how participants were continually updating the caregiver team, which captured how health information, including their communication motivations and intentions, was shared among family and hired caregiver participants. The subthemes included binder-based health documentation, digital health documentation, and communication practices beyond the binder. The second theme described how participants were learning to improve care and decision-making, which captured how they acted on information from various sources to provide care. The subthemes included developing expertise as a family caregiver and tailoring expertise as a hired caregiver. The third theme described how participants experienced conflicts within caregiver teams, which captured the different struggles arising from, and the causes of, breakdowns in communication and coordination between family and hired caregiver participants. The subthemes included 2-way communication and trusting the caregiver team.

Conclusions
This study highlights the health information communication and coordination challenges and experiences that family and hired caregivers face in complex home care settings for older adults. Given the challenges of this work domain, there is an opportunity for appropriate digital technology design to improve complex home care. When designing complex home care technologies, it will be critical to include the overlapping and disparate perspectives of family and hired caregivers collectively providing home care for older adults with complex needs to support all caregivers in their vital roles.
Efficacy of Digital Dance on Brain Imagery, Cognition, and Health: Randomized Controlled Trial
Authors: Tung Heng-Hsin , Kuo Chen-Yuan , Lee Pei-Lin , Chang Chih-Wen , Chou Kun-Hsien , Lin Ching-Po , Chen Liang-Kung 
Published: July 2024

Background
Multidomain interventions have demonstrable benefits for promoting healthy aging, but self-empowerment strategies to sustain long-term gains remain elusive.

Objective
This study evaluated the effects of digital somatosensory dance game participation on brain imagery changes as primary outcomes and other physical and mental health measures as secondary outcomes related to healthy aging.

Methods
Between August 31, 2020, and June 27, 2021, this randomized controlled trial recruited 60 eligible participants older than 55 years with no recent engagement in digital dance games. A computer-generated randomization sequence was used to allocate participants 1:1, without stratification, to an intervention group (n=30) who underwent digital somatosensory dance game training or a control group (n=30). An anonymized code masked the intervention allocations from the investigators, and individuals who assigned the interventions were not involved in analyzing the study data. The intervention entailed two 30-minute dance game sessions per week for 6 months, and the control group received healthy aging education. Primary outcomes were brain imagery changes. All variables were measured at baseline and the 6-month follow-up, and intervention effects were estimated using t tests with intention-to-treat analyses.

Results
Compared with the control group, intervention participants had significantly different brain imagery in the gray matter volume (GMV) of the left putamen (estimate 0.016, 95% CI 0.008 to 0.024; P<.001), GMV of the left pallidum (estimate 0.02, 95% CI 0.006 to 0.034; P=.004), and fractional amplitude of low frequency fluctuations of the left pallidum (estimate 0.262, 95% CI 0.084 to 0.439; P=.004). Additionally, the intervention group had different imagery in the cerebellum VI GMV (estimate 0.011, 95% CI 0.003 to 0.02; P=.01). The intervention group also had improved total Montreal Cognitive Assessment scores (estimate 1.2, 95% CI 0.27 to −2.13; P<.01), quality of life (estimate 7.08, 95% CI 2.35 to 11.82; P=.004), and time spent sitting on weekdays (estimate −1.96, 95% CI −3.33 to −0.60; P=.005). Furthermore, dance performance was significantly associated with cognitive performance (P=.003), health status (P=.14), resilience (P=.007), and demoralization (P<.001).

Conclusions
Digital somatosensory dance game participation for 6 months was associated with brain imagery changes in multiple regions involving somatosensory, motor, visual, and attention functions, which were consistent with phenotypic improvements associated with healthy aging.

Trial Registration
ClinicalTrials.gov NCT05411042; https://clinicaltrials.gov/study/NCT05411042
Ảnh hưởng của kích thích tố khác nhau đến sinh sản của cá sát sọc (Pangasius macronema Bleeker, 1851)
Authors: Tran Đông Phương An , Bùi Minh Tâm , Phạm Thanh Liêm , Trần Ngọc Hoài Nhân , Nguyễn Văn Triều 
Published: July 2024

Cá sát sọc (Pangasius macronema) là loài có giá trị kinh tế và đã nuôi trong lồng ở đồng bằng sông Cửu Long, Việt Nam sử dụng giống tự nhiên. Nghiên cứu này nhằm xác định loại và liều lượng kích thích tố có hiệu quả để kích thích cá sinh sản. Nghiên cứu được thực hiện với hormone HCG và Ovaprim ảnh hưởng lên sự rụng trứng của cá. Thí nghiệm với HCG gồm 4 nghiệm thức (NT) với liều tiêm khác nhau và 3 lần lặp lại: NT 1.1 (5.000 UI/kg), NT 1.2 (5.500 UI/kg), NT1.3 (6.000 UI/kg) và NT1.4 (6.500 UI/kg) cho cá cái. Thí nghiệm với ovaprim gồm 3 nghiệm thức với các liều gồm: NT2.1 (0,4 mL/kg), NT 2.2 (0,5 mL/kg) và NT 2.3 (0,6 mL/kg) cho cá cái. Kết quả nghiên cứu cho thấy, HCG ở liều 6.000 UI/kg cá cái (NT1.3) có hiệu quả tốt với tỷ lệ rụng trứng 77,33%, sức sinh sản tương đối thực tế 48.009 trứng/kg cá cái, tỉ lệ thụ tinh 70,31% và tỷ lệ nở 66,58%. Ovaprim với liệu 0,4-0,6ml/kg cá cái chưa có hiệu quả kích thích cá rụng trứng.
Đánh giá hiệu giá kháng thể kháng bệnh Gumboro và Newcastle trên gà tre, gà nòi và gà Minh Dư
Authors: Lê Thị Kim Tuyến , Nguyễn Thị Vân Anh , Nguyễn Thị Kiều Oanh , Quách Tuyết Anh , Chế Công Hậu , Phạm Đức Anh 
Published: July 2024

Nghiên cứu đã được thực hiện tại cùng một trại chăn nuôi ở tỉnh Tiền Giang nhằm đánh giá hiệu giá kháng thể (HGKT) của gà tre, gà nòi và gà Minh Dư sau khi chủng vaccine phòng bệnh Gumboro (IBD) và Newcaslte (ND). Có 300 mẫu huyết thanh được xét nghiệm ELISA để xác định HGKT kháng virus IBD (IBDV) và virus ND (NDV) của cả 3 giống gà lúc 1, 28, 35, 49 và 63 ngày tuổi. Trong đó, Gà Minh Dư có HGKT kháng IBDV mẹ truyền cao hơn gà nòi và gà tre (p<0,05). Tuy nhiên, gà tre có HGKT kháng IBDV ổn định hơn gà nòi và gà Minh Dư trong suốt thí nghiệm. Sau 14 ngày chủng vaccine phòng Newcastle, HGKT kháng NDV của gà Minh Dư, nòi và tre lần lượt là 8.625, 7.654 và 6.062 (titer) (p<0,05). Tương tự, vào 28 ngày sau tiêm, HGKT kháng NDV của giống gà Minh Dư vẫn cao hơn gà tre và gà nòi (p<0,05). Tóm lại, cả ba giống gà đều đáp ứng miễn dịch tốt và đạt chuẩn trung bình bảo hộ với vaccine phòng bệnh IBD và ND trong thí nghiệm.
Adolescent Reproductive Health Education as an Effort to Increase Reproductive Health Knowledge and Marriage Readiness in Mancasan Kleben Village
Authors: Suryana Rika , Rivaldi Muhammad , Ninditya Vika Ichsania , Ramadhany Defy Rizky , Khatimah Khusnul , Tasmara Fikhri Astina , Amalia Reski 
Published: July 2024

Adolescents in Yogyakarta encounter social disputes, klitih, cyberbullying,and reproductive health challenges,which have an impact on early marriage rates.Guidance from parents, communities, and the government is critical in minimizing juvenile criminality. To address issues such as unwanted pregnancies, unsafe abortions, and maternal mortality concerns, reproductive health education is critical. The Postgraduate Student Association of Universitas Gadjah Mada implemented the community engagement to educate teenagers in Mancasan Kleben Village, Pandowoharjo, Sleman Regency, Yogyakarta, about the importance of information on reproductive health in order to prevent early marriage and the transmission of sexual infections.The educational activity is conducted by giving lectures, pretest and post-test questionnaires, and discussion methods. The questionnaire’s results were analyzed using the t-test method. The result of the effect of education on reproductive health knowledge (76.25±7.621;80.61±3.047), and the impact of counseling on reproductive health knowledge is evident (12.80±2.28;21.27±1.71), and the effect on adolescent attitudes (58.20±4.38;65.73±7.51). Education about reproductive health and juvenile delinquency substantially impacts young people’s knowledge in Mancasan Kleben. The Postgraduate Student Association of Universitas Gadjah Mada activity was successfully implemented although the results were not statistically significant. Larger-scale service operations must be sustained to ensure that these outcomes give broader advantages.
GESTÃO ÁGIL DE PROJETOS: APLICAÇÃO EM UM SETOR DE REGISTRO ACADÊMICO
Authors: Mariot Cibele , Gruber Vilson , Marcelino Roderval 
Published: July 2024

Objetivo: identificar os impactos da aplicação de um modelo ágil de gerenciamento de projetos para o contexto dos processos de um setor de Registro Acadêmico.

Método/abordagem: pesquisa qualitativa. Análise comparativa entre o cenário anterior e o posterior à aplicação das metodologias ágeis de gestão de projetos, por meio de um estudo de caso realizado no âmbito de um setor de Registro Acadêmico do Instituto Federal de Santa Catarina. Pesquisa desenvolvida no período de novembro de 2020 a maio de 2021, da qual participaram cinco servidores do setor. A geração de materialidades foi realizada por meio de observação participante, grupo focal e questionário.

Principais Resultados: observou-se que o setor pesquisado não fazia uso de ferramentas ágeis, nem de um modelo de gestão. Após a aplicação da pesquisa, constatou-se que o modelo proposto foi apropriado para ser utilizado no setor. Identificou-se, entre outras, duas principais contribuições: melhora no entendimento dos processos resultando na criação de uma visão sistêmica pela equipe, e organização geral do setor.

Contribuições teóricas/práticas/sociais: contribui para o avanço de pesquisas sobre gestão de projetos apresentando uma revisão bibliográfica sobre o tema e investigando o desenvolvimento de estratégias de gestão que poderão contribuir para a melhoria do serviço público prestado pela instituição participante, bem como, serem adotadas por outras instituições de ensino.

Originalidade/relevância: a relevância deste estudo se justifica pela necessidade de melhorar os processos realizados no setor pesquisado e pela carência de estudos no que tange à utilização de metodologias de gestão de projetos em setores de Registro Acadêmico de Instituições de Ensino.
Overexpressed Poldip2 Incurs Retinal Fibrosis via the TGF-β1/SMAD3 Signaling Pathway in Diabetic Retinopathy
Authors: Ji Zhiyu , Lin Siyu , Gui Siyu , Gao Jie , Cao Fan , Guan Yiming , Ni Qinyu , Chen Keyang , Tao Liming , Zhengxuan Jiang 
Published: July 2024

Retinal fibrosis is one of the major features of diabetic retinopathy (DR). Our recent research has shown that Poldip2 can affect early DR through oxidative stress, but whether Poldip2 would regulate retinal fibrosis during DR development is still enigmatic. Here, diabetic Sprague-Dawley (SD) rats were induced with streptozotocin (STZ) and treated with adeno-associated virus serotype 9–polymerase-δ interacting protein 2 (Poldip2) shRNA, while human adult retinal pigment epithelial (ARPE-19) cells were treated with high glucose or Poldip2 siRNA. We identified that in STZ-induced DR rats and ARPE-19 cells treated with high glucose, the expression of Poldip2, transforming growth factor-β1 (TGF-β1), phosphorylated-SMAD3/SMAD3, MMP9, COL-1, FN, and CTGF increased while the expression of cadherin decreased. However, deleting Poldip2 inhibited the TGF-β1/SMAD3 signaling pathway and attenuated the above protein expression in vivo and in vitro. Mechanistically, we found that Poldip2 promotes the activation of SMAD3, facilitates its nuclear translocation through interacting with it, and significantly enhances the expression of fibrosis makers. Collectively, Poldip2 was identified is a novel regulator of DR fibrosis and is expected to become a therapeutic target for PDR.

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