bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antiproliferative effect of low-level laser/ photobiomodulation on gingival fibroblasts derived from calcium channel blocker-induced gingival overgrowth
Authors: slezovic Melis özgül , Saygun Işıl , Bengi Vahdi Umut , Serdar Muhittin , Kantarci Alpdogan 
Published: July 2024

Abstract
The aim of this study was to evaluate the antiproliferative properties of low-level laser therapy (LLLT) on gingival fibroblasts obtained from calcium channel blocker-induced gingival overgrowth (GO). Gingival fibroblasts of patients with GO were compared to healthy gingival fibroblasts (H). Both cells were exposed to LLLT (685 nm wavelength, 25mW power, diode laser) and compared to those not treated with LLLT. Cell proliferation and viability were measured with MTT assay at baseline and after 24 and 72 h. TGF-β1, CTGF, and collagen Type 1 levels were evaluated with Enzyme-Linked Immunosorbent Assay (ELISA). LLLT significantly decreased the proliferation of GO fibroblasts (p < 0.05) while leading to a significantly higher proliferation in H fibroblasts compared to the untreated cells (p < 0.05). GO cells showed significantly higher CTGF, TGF-β, and collagen Type 1 expression than the H cells (p < 0.05). LLLT significantly reduced CTGF levels in GO cells compared to the control group (p < 0.05). In H cells, CTGF and TGF-β levels were also significantly decreased in response to LLLT compared to the control group (p < 0.05). While LLLT significantly reduced collagen expression in the H group (p < 0.05), it did not significantly impact the GO cells. LLLT significantly reduced the synthesis of the growth factors and collagen in both groups with an antiproliferative effect on the gingival fibroblasts from calcium channel blocker-induced GO, suggesting that it can offer a therapeutic approach in the clinical management of drug-induced GO, reversing the fibrotic changes.
Academics’ susceptibility to disruptions of their research productivity: empirical insights from the COVID-19 pandemic
Authors: Püttmann Vitus , Thomsen Stephan L. 
Published: July 2024

AbstractThe circumstances during the COVID-19 pandemic severely disrupted research activities, but did not affect all academics equally. Understanding which academics were susceptible to disruptions is essential for gauging and addressing the pandemic’s systemic consequences and can yield insights into influences on research productivity more generally. Based on the survey responses of 1891 university professors in Germany, we estimate multivariate models to investigate the relevance of a comprehensive set of factors that may have shaped the pandemic’s impact. We furthermore use sample splits and an econometric decomposition technique to analyze disciplinary and gender differences. Our findings show that some factors, including additional time demands for care responsibilities and negative spillovers from disruptions of teaching activities, are of general relevance, whereas the relevance of other factors varies between groups of academics. In the natural and engineering sciences, the dependence on access to research facilities seems to have led to a more uniform negative impact of the pandemic. This apparently rendered the work environment an important influence on academics’ susceptibility to disruptions. In the humanities and social sciences, where the pandemic’s impact was more heterogeneous, individual conditions such as seniority played a notable role. Most of these factors identified as relevant were furthermore more influential among female academics, who seem to experience greater challenges with shielding their research activities from disruptions. Overall, our investigation highlights the complexity of mechanisms worth taking into account for policy and management efforts concerned with academics’ research productivity, within and outside of the context of the pandemic.
Excite, or Take Flight? Exploring the Relationship between Difficulties with Emotion Regulation, Outcome Expectancies, and Problem Gambling
Authors: Lee Annabelle , Flack Mal , Caudwell Kim M. 
Published: July 2024

Abstract
Emotional dysregulation is a transdiagnostic process associated with a range of addictive behaviours including problem gambling, with emerging research indicating that emotionally oriented reasons for gambling (i.e., excitement, escape) are associated with problem gambling. However, the relationships between difficulties with emotion regulation, reasons for gambling, and problem gambling, are unclear. The current study tested whether the association between difficulties with emotion regulation and problem gambling could be explained by escape and excitement gambling outcome expectancies. A total of 187 regular gamblers recruited via social media (50.3% male, 48.7% female) completed measures of difficulties with emotion regulation, gambling outcome expectancies, and problem gambling severity (M

age
= 41.07, SD = 15.8). Analyses revealed that escape outcome expectancies partially mediated the relationship between difficulties with emotion regulation and problem gambling severity. However, the mediating effect of excitement on this relationship was not significant. The findings suggest that individuals with greater emotional regulation difficulties may engage in problem gambling to help manage aversive emotional states. The study’s findings illustrate the importance of considering emotional dysregulation and outcome expectancies in problem gambling treatment planning and public health strategies.
Patients’ Needs Regarding Work-Focused Healthcare: A Qualitative Evidence Synthesis
Authors: Hagendijk Marije E. , Zipfel Nina , Melles Marijke , van der Wees Philip J. , Hulshof Carel T. J. , Zwaan Elmi , van der Burg-Vermeulen Sylvia J. , Hoving Jan L. 
Published: July 2024

Abstract
Purpose
To identify, appraise, and synthesize qualitative research evidence exploring patients’ needs regarding work-focused healthcare.

Methods
A systematic review was conducted in accordance with the PRISMA statement guidelines to identify studies reporting patients’ needs regarding work-focused healthcare. Four databases (MEDLINE, Embase, PsychInfo and Web of Science) were systematically searched from January 2000 until May 2023 and screened in duplicate by pairs of two reviewers. Inclusion criteria were qualitative data collection method, and patients’ perspectives regarding healthcare focusing on work when experiencing work-related problems due to chronic medical conditions. Data extraction and synthesis was executed by means of an inductive thematic analysis approach. The quality of the included studies was assessed using the CASP Qualitative Study checklist. Confidence in the review findings was assessed through the Confidence in the Evidence from Reviews of Qualitative research (CERQual) approach.

Results
Out of 23,677 records, 97 qualitative studies were included. Needs regarding four main themes were identified: (1) Substantive guidance, which comprises the specific content of work-focused healthcare; (2) Clear and continuous process, which comprises clarification and optimization of the work-focused healthcare process; (3) Supportive attitude and behavior, which comprises a positive and supportive attitude and behavior from professionals towards the patients; and (4) Tailored approach, which comprises the delivery of tailored care to the individuals’ needs. 17 subthemes were identified.

Conclusion
The broader insight in patients’ needs in work-focused healthcare can help (occupational) healthcare professionals adopt a more patient-centred approach in practice.
The novel CFTR haplotype E583G/F508del in CFTR-related disorder
Authors: De Paolis Elisa , Tilocca Bruno , Inchingolo Riccardo , Lombardi Carla , Perrucci Alessia , Maneri Giulia , Roncada Paola , Varone Francesco , Luca Richeldi , Urbani Andrea , Minucci Angelo , Santonocito Concetta 
Published: July 2024

Abstract

Background
CFTR-related disorder (CFTR-RD) is a clinical entity associated to complex diagnostic paths and newly upgraded standard of care. In CFTR-RD, CFTR genotyping represents a diagnostic surrogate marker. In case of novel haplotype, the diagnosis could represents an area of concern. We described the molecular evaluation of the rare CFTR variant E583G identified in trans with the F508del in a novel haplotype.

Methods and results
An adult woman was referred to our pulmonary unit for persistent respiratory symptoms. CFTR Next Generation Sequencing was performed to evaluate full-gene mutational status. The variant identified was evaluated for its pathogenicity integrating clinical evidences with dedicated bioinformatics analyses. Clinical evaluation of patient matched with a mono-organ CFTR-RD diagnosis. Genotyping revealed the novel CFTR haplotype F508del/E583G. Multiple evidences of a deleterious effect of the CFTR E583G rare variant emerged from the bioinformatics analyses performed.

Conclusions
Guidelines for CFTR-RD are available with the purpose of harmonizing clinical and molecular investigations. In such context, the identification of novel CFTR haplotype need to a deeper evaluation with a combination of skills. The novel E583G variant could be considered of clinical interest and overall a CFTR-RD Variants of Varying Clinical Consequences.
Comparison of robotic-assisted total knee arthroplasty: an updated systematic review and meta-analysis
Authors: Fu Xinyu , She Yiming , Jin Guangwen , Liu Chengri , Liu Ze , Li Wei , Jin Ri 
Published: July 2024

AbstractThis study was conducted to compare the changes in different clinical scores and imaging indexes of patients who underwent robot-assisted total knee arthroplasty (RA-TKA) and manual total knee arthroplasty (M-TKA). PubMed, Web of Science, Cochrane Library and Embase were searched according to PRISMA guidelines in June 2024. Search terms included “robot-assisted”, “manual” and “total knee arthroplasty”. Outcome indicators included American Knee Society Score (KSS), Western Ontario McMaster Universities Osteoarthritis Index (WOMAC), Oxford Knee Score (OKS), range of motion (ROM), Hospital for Special Surgery (HSS) score, Forgotten Joint Score (FJS), 36-Item Short Form Health Survey (SF-36), operation duration (min), intraoperative blood loss (ml), pain score, patient’s satisfaction scores, hip–knee–ankle (HKA) angle, frontal femoral component angle, frontal tibia component angle, lateral femoral component angle and lateral tibia component angle. A total of 1,033 articles were obtained after removing duplicates, and 12 studies involving 2,863 patients (1,449 RA-TKAs and 1,414 M-TKAs) were finally meta-analyzed (22–32). The baseline data of both groups were similar in all results. Meta-analysis suggested a better performance of the RA-TKA group than the M-TKA group regarding the HKA angle. The manual TKA reduced the operation time and significantly improved the range of motion. The results of > 6 months follow-up showed that M-TKA was better than RA-TKA in terms of KSS score and WOMAC. Compared with M-TKA, RA-TKA can produce more accurate prosthetic alignment, but it does not lead to better clinical results. Orthopedic surgeons should choose between two surgical procedures according to their own experience and patients’ characteristics.
The influence of metal ion mixtures on the activity of activated sludge
Authors: Matyja Konrad , Wika Aneta , Czyżewska Katarzyna , Dobicki Wojciech , Pokorny Przemysław 
Published: July 2024

Abstract
Environmental contamination with heavy metals is inherent in the development of industries. They can be present in municipal and industrial wastewaters, reach biological wastewater treatment plants (WWTPs), and affect the performance of the activated sludge process. Moreover, heavy metals almost never occur in isolation and are components of toxic mixtures. Therefore in this study, the influence of binary metal mixtures Cd–Cu, Cd–Zn, and Cu–Zn on activated sludge dehydrogenase activity was evaluated. Two different models were used to identify possible interactions between mixture components: the concentration addition (CA) model and the independent action (IA) model. It seems that the mode of toxic interaction between mixture components strongly depends on the chosen prediction model and measured endpoint. The joint toxicity of studied mixtures was better described by the IA model compared to the CA model.
P=W phenomena in algebraic and enumerative geometry
Authors: Felisetti Camilla 
Published: July 2024

Abstract
In view of the recent proofs of the P=W conjecture, the present paper reviews and relates the latest results in the field, with a view on how P=W phenomena appear in multiple areas of algebraic geometry. As an application, we give a detailed sketch of the proof of P=W by Maulik, Shen and Yin.
Master’s degree studies and its impact on vertical and horizontal mismatch in Spain
Authors: Morejón Cabrera Gabriela , Mariel Petr 
Published: July 2024

AbstractThe goal of this study is to analyse the vertical and horizontal mismatches of graduates in the Spanish labour market focusing on the effect that a master’s degree has in each of these two mismatches. The analysis is based on the data from the Survey on the Labour Insertion of University Graduates carried out by the Spanish Statistical Office in 2019. The main conclusions stress the importance of vertical and horizontal mismatches in the Spanish labour market. The results of the quantitative analysis based on the binary and ordered logit indicate that the master’s degree can reduce the vertical mismatch. Moreover, a wider offer of master’s degrees in some fields such as health could reduce the horizontal mismatch. Eventually, some policy measures to reduce the two mismatches are proposed. To the best of our knowledge, this is the first study to analyse both horizontal and vertical job-education mismatches among Spanish graduates, including those with a Master's degree. Thus, this study is pioneering in assessing the impact of Master's degrees in reducing educational mismatches. In addition, it shows how the likelihood of these mismatches changes with increasing work experience.
Recent developments of nano-enhanced composite membranes designed for water/wastewater purification—a review
Authors: Vo Thi Sinh , Lwin Khin Moe , Kim Kyunghoon 
Published: July 2024

AbstractIn this review, the latest advances on nano-enhanced composite membranes (NECMs, which contain nanostructured filler-like materials and nanoscale barrier polymeric substrates), comprising basic conceptions, working mechanisms, selection of active materials, structural designs, desirable effects, existing challenges, and potential applications for water/wastewater purification, were summarized and discussed in detail. This review paper will propose a comprehensive overview of NECMs designed for water/wastewater purification to understand the recent developments among active materials, strategies, or challenges regarding technical and innovative approaches. Several researchers have successfully proven the main capacities regarding adsorption and separation to remove various pollutants from water or wastewater. Herein, the NECMs designed by combining nanostructured filler-like materials and nanoscale barrier polymeric substrates have high performances of adsorption and separation; thus, these NECMs have attracted considerable attention in recent years. Given their nanostructured filler-like materials, NECMs can address fouling-related limitations by tailoring their surface features, particularly the structural design and desirable effect of NECMs; concomitantly, their performance might be enhanced through the use of a specific composition and structure of nanomaterials. Hence, a comprehensive guide of the advanced NECMs for water/wastewater purification, which are constructed on nanostructured filler-like materials, will be provided in detail. Therefore, this paper can provide a comprehensive understanding of NECMs that are designed for water/wastewater purification correspondingly and effectively.
Graphical Abstract
Scalable Cellular V2X Solutions: Large-Scale Deployment Challenges of Connected Vehicle Safety Networks
Authors: Shah Ghayoor , Zaman Mahdi , Saifuddin Md , Toghi Behrad , Fallah Yaser 
Published: July 2024

AbstractVehicle-to-Everything (V2X) communication is expected to accomplish a long-standing goal of the Connected and Autonomous Vehicle (CAV) community to bring connected vehicles to roads on a large scale. A major challenge, and perhaps the biggest hurdle on the path towards this goal, is the scalability issues associated with it, especially when vehicular safety is concerned. As a major stakeholder, Cellular V2X (C-V2X) community, which is based on the 3rd Generation Partnership Project (3GPP), has long been trying to research on whether vehicular networks are able to support the safety-critical applications in high-density vehicular scenarios. This paper attempts to answer this question by first presenting an overview on the scalability challenges faced by 3GPP Release 14 Long Term Evolution C-V2X (LTE-V2X) using the PC5 sidelink interface for low and heavy-density traffic scenarios. Next, it demonstrates a series of solutions that address network congestion, packet losses, and other scalability issues associated with LTE-V2X to enable this communication technology for commercial deployment. In addition, a brief survey is provided into 3GPP Release 16 5G New Radio V2X (NR-V2X) that utilizes the NR sidelink interface and works as an evolution of C-V2X towards better performance for V2X communications, including new enhanced V2X (eV2X) scenarios that possess ultra-low-latency and high-reliability requirements.
Sustainability of cool and black roofs with high initial construction moisture
Authors: Saber Hamed H. 
Published: July 2024

AbstractThis study examines the sustainability of roofs subjected to hot climate of Phoenix and cold climate of Montréal by using a validated numerical model that simultaneously solves the heat, air, and moisture equations. In many situations, the initial conditions needed to solve these equations are not available. This paper provides a procedure for conducting energy and moisture modelling so that using different initial conditions would result in no effect on the final results of roof performance. Additionally, the study focuses on: (a) assessing the moisture performance of black and cool roofs in case of using material layer with high initial construction moisture content (Fibreboard, FB), (b) identifying the time period needed so that the moisture content would reach acceptable limit by the building codes, and (c) determining the amount of energy savings as a result of using sustainable cool roofs instead of black roofs. The results show that the moisture content in the FB decreases to permissible levels after 92.6 days for black roof and 175.7 days for cool roof in Phoenix, while in Montréal, it takes 238.6 days and 1597 days, respectively. The effect of using different initial condition vanishes after 196 days for Phoenix’s black roof, 583 days for its cool roof, and 1247 days for Montréal’s black roof and 4590 days for its cool roof. Mold is detected in FB. In Phoenix, mold disappears after 379 days for black roof and 479 days for cool roof, whereas in Montréal, it takes 708 days and 3143 days, respectively.
Exploring the enzymatic repertoires of Bacteria and Archaea and their associations with metabolic maps
Authors: Tenorio-Salgado Silvia , Villalpando-Aguilar José Luis , Hernandez-Guerrero Rafael , Poot-Hernández Augusto César , Perez-Rueda Ernesto 
Published: July 2024

AbstractThe evolution, survival, and adaptation of microbes are consequences of gene duplication, acquisition, and divergence in response to environmental challenges. In this context, enzymes play a central role in the evolution of organisms, because they are fundamental in cell metabolism. Here, we analyzed the enzymatic repertoire in 6,467 microbial genomes, including their abundances, and their associations with metabolic maps. We found that the enzymes follow a power-law distribution, in relation to the genome sizes. Therefore, we evaluated the total proportion enzymatic classes in relation to the genomes, identifying a descending-order proportion: transferases (EC:2.-), hydrolases (EC:3.-), oxidoreductases (EC:1.-), ligases (EC:6.-), lyases (EC:4.-), isomerases (EC:5.-), and translocases (EC:7-.). In addition, we identified a preferential use of enzymatic classes in metabolism pathways for xenobiotics, cofactors and vitamins, carbohydrates, amino acids, glycans, and energy. Therefore, this analysis provides clues about the functional constraints associated with the enzymatic repertoire of functions in Bacteria and Archaea.
Enforcement Design Patterns in EU Law: An Analysis of the AI Act
Authors: Söderlund Kasia , Larsson Stefan 
Published: July 2024

AbstractIn recent decades, the enforcement of European Union (EU) law has transitioned from being primarily the responsibility of Member States to becoming an increasingly shared or centralised task at the EU level. Drawing on the concept of legal design patterns, this article presents these two broadly understood enforcement approaches as decentralised and centralised enforcement patterns, and examines the AI Act through this conceptual lens. The objective of this exploration is to highlight that the choice of enforcement mechanisms for EU laws comes with different sets of challenges, in general, and to contribute to the understanding of the AI Act’s enforcement structure, in particular. In this paper, we ground our analysis on the theoretical framework of legal design patterns in order to reduce the regulatory complexity into comparable problem-solving elements. Under this framework, we (1) examine the enforcement framework of the AI Act, and we (2) draw comparative lessons from the General Data Protection Regulation (GDPR), an EU legislation which is based on the largely decentralised enforcement model. On this basis, we (3) discuss some of the potential implications of the decentralised enforcement of the AI Act, and consider the possible reasons behind this choice of enforcement model.
Spatial digital twin framework for overheight vehicle warning and re-routing system
Authors: Trembearth Oliver , Sun Qian , Wang Siqin , Duckham Matt 
Published: July 2024

AbstractOverhead road obstacles present a significant logistical hazard to the heavy vehicle industry. Traditional overheight vehicle warning systems such as passive warning systems (PWS) and active warning systems (AWS) have not adequately reduced the frequency and impact of overheight incidents, encouraging transportation agencies to employ intelligent transport system (ITS) strategies using state-of-the-art advanced technologies. This research takes an innovative approach in developing an immersive user-focused experience, harnessing multi-disciplinary methods and tools to engineer a spatial digital twin prototype for a novel Internet-of-Things (IoT)-based active warning alert and re-routing system (AWARS). LiDAR and 3D GIS were used to model the complex road environment, tailored to the strict fiscal objectives sought by economically mindful organisations. Tree crowns were extracted from near-Infrared aerial imagery and digital elevation models, supplying the dimensions necessary for 3D tree modelling. IoT connectivity was configured using a real-time analytics approach to deliver alerts and re-routing options. The World Traffic Service with live and predictive traffic data was used for the routing application programming interface (API). A standard-configuration common rigid truck (CRT) was inserted into the 3D road environment model to simulate overheight collisions and to ascertain the effect of re-routing on estimated time of arrival (ETA). Longer ETA durations were observed for routes computed by the digital twin. Theoretically, enhanced situational awareness and subsequent reduction of risk likelihood suggests an optimised response to industry demands, despite extended travel times, cultivating a favorable impact on the supply chain through enhanced safety management.