bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute and severe acne in a patient treated with bevacizumab
Authors: Molina‐Ruiz Ana María , Domine Manuel , Requena Luis 
Published: February 2013

AbstractBackground  Bevacizumab is a recombinant, humanized monoclonal antibody against vascular endothelial growth factor (VEGF) that inhibits angiogenesis. Bevacizumab is typically well tolerated; its major side effects include hypertension, proteinuria, bleeding, gastrointestinal perforation, and arterial thrombotic events, among others. Cutaneous side effects associated with the use of bevacizumab are rare and involve mainly itching and exfoliative dermatitis. Nonspecific skin rash and acneiform eruptions have recently been described in patients following infusion of bevacizumab.Methods  Findings in a 52‐year‐old patient with stage IV lung cancer with brain metastasis, who developed severe, acute, and persistent acne after intravenous (IV) infusion of bevacizumab, are examined.Results  The cutaneous eruption was classified as true acne rather than as an acneiform eruption because all cutaneous lesions of acne, namely comedones, inflammatory papules, and pustules, were present.Conclusions  To the authors’ knowledge, this is the first report of an association between acne and IV administration of bevacizumab.
It's not what you are, it's what you know: experience, beliefs, and the detection of deception in employment interviews
Authors: Reinhard Marc‐André , Scharmach Martin , Müller Patrick 
Published: February 2013

AbstractThis study investigated the ability of more or less experienced employment interviewers and laypersons to detect deception in employment interviews. Although correct beliefs about indicators of deception led to higher deception detection accuracy, more experienced employment interviewers did not show more accurate beliefs about indicators of deception and did not perform better at detecting deception than less experienced interviewers and laypersons. Furthermore, more experienced interviewers showed a less‐pronounced tendency of judging messages as true irrespective of their actual truthfulness (truth bias) than less experienced interviewers and laypersons. It is suggested that experience in employment interviewing does not automatically lead to higher deception detection abilities in employment interviews, but that correcting people's beliefs about indicators of deception can do so.
Toll‐like receptors in hepatitis C infection: Implications for pathogenesis and treatment
Authors: Howell Jessica , Angus Peter , Gow Paul , Visvanathan Kumar 
Published: February 2013

AbstractHepatitis C virus (HCV) infection is a significant global health problem, affecting over 150 million people worldwide. While the critical role of the adaptive immune system in HCV infection is well‐established, the importance of the innate immune system in HCV infection has only been recognized in more recent years. Toll‐like receptors form the cornerstone of the innate immune response, and there is considerable evidence for their crucial role in hepatitis C infection. This review outlines recent advances made in our understanding of the role of Toll‐like receptor function in HCV infection, exploring how HCV manipulates host immunity to evade immune clearance and establish persistent infection despite leading to inflammatory hepatic damage.
Automatic predicate abstraction of C programs
Authors: Ball Thomas , Majumdar Rupak , Millstein Todd , Rajamani Sriram K. 
Published: February 2013

Model checking has been widely successful in validating and debugging designs in the hardware and protocol domains. However, state-space explosion limits the applicability of model checking tools, so model checkers typically operate on abstractions of systems.
Recently, there has been significant interest in applying model checking to software. For infinite-state systems like software, abstraction is even more critical. Techniques for abstracting software are a prerequisite to making software model checking a reality.
We present the first algorithm to automatically construct a predicate abstraction of programs written in am industrial programming language such as C, and its implementation in a tool -- C2BP. The C2BP tool is part of the SLAM toolkit, which uses a combination of predicate abstraction, model checking, symbolic reasoning, and iterative refinement to statically check temporal safety properties of programs.
Predicate abstraction of software has many applications, including detecting program errors, synthesizing program invariants, and improving the precision of program analyses through predicate sensitivity. We discuss our experience applying the C2BP predicate abstraction tool to a variety of problems, ranging from checking that list-manipulating code preserves heap invariants to finding errors in Windows NT device drivers.
Parenting for resilience: family processes and psychosocial competence of Chinese adolescents experiencing economic disadvantage in Hong Kong
Authors: Leung Janet T.Y. , Shek Daniel T.L. 
Published: February 2013

Abstract
Based on the responses of 275 Chinese adolescents experiencing economic disadvantage in Hong Kong, the relationships between family processes (including perceived parenting style, parental control, family functioning, and parental sacrifice for children’s education) and psychosocial competence were examined in this study. Results showed that parenting style, parental control, family functioning, and parental sacrifice for children’s education were positively related to adolescent psychosocial competence. Regression analyses indicated that family functioning, maternal control, and paternal sacrifice for children’s education were significant predictors of psychosocial competence of adolescents experiencing economic disadvantage. The theoretical and practical implications of the findings are discussed.
Ultra-Shallow Junctions for the 65nm Node Based on Defect and Stress Engineering
Authors: Moroz Victor , Foad Majeed , Graoui Houda , Nouri Faran , Pramanik Dipu , Felch Susan 
Published: February 2013

AbstractThe co-implantation of germanium, carbon, and boron with the optimum implant energies and doses makes it possible to create p+/n junctions with the sheet resistance of less than 600 Ohm/square and the slope of less than 3 nm/decade. The narrow process window is based on careful engineering of the amorphization, point defects, and stresses and includes standard 1050°C spike annealing. The germanium pre-amorphization suppresses the ion channeling for the subsequent boron implant. The tensile stress induced by the substitutional carbon atoms and the compressive stress induced by the substitutional germanium atoms slow down boron diffusion and help to make the junctions shallower. The stress gradient in the transition region from the strained carbon and germanium doped layers to the relaxed silicon underneath creates an uphill boron flux that makes the junction slope steeper.The optimum amount of carbon is placed in between the implanted boron and the implant damage, which is located below the amorphized layer. During the annealing, the carbon atoms capture silicon interstitials that are coming from the implant damage and form carbon-interstitial clusters. The analysis demonstrates that it is possible to capture over 95% of the interstitials this way before they have a chance to reach boron-doped layer. This completely suppresses the transient-enhanced boron diffusion (TED) and drastically reduces the amount of boron that is deactivated in boron-interstitial clusters (BICs). In fact, the point defect engineering with an optimized carbon profile allows to remove all non-equilibrium silicon interstitials that are generated by the following three sources: the implant damage below the amorphized layer, the rapid temperature ramp down, and the interstitials generated by boron at high concentrations (due to the effect known as boron-enhanced diffusion (BED)).The latter effect leads to significant increase of the apparent boron activation level beyond the well-characterized solid-state solubility level. We explain this effect as a reduction in formation of BICs due to the lack of interstitial supersaturation. In carbon-free silicon, high concentration boron is always accompanied by the non-equilibrium interstitials, coming from either the implant damage or the BICs even if boron is introduced into silicon by pre-deposition instead of the implantation. Extensive experiments and theoretical analysis based on simulation of the interaction of Ge, C, I, and B atoms, as well as the stress effects, point to the optimized process flow that improves the shape and parameters of the p+/n USJs.
The Relation between Renal Function and Serum Sclerostin in Adult Patients with CKD
Authors: Pelletier Solenne , Dubourg Laurence , Carlier Marie-Christine , Hadj-Aissa Aoumeur , Fouque Denis 
Published: February 2013

Summary

Background and objectives
Sclerostin, a bone antianabolic peptide involved in osteoporosis, is elevated in patients undergoing maintenance dialysis. However, there are no data for patients with early CKD.

Design, setting, participants, & measurements
Between January and July 2010, serum sclerostin and GFR (calculated by inulin clearance) were measured in 90 patients with CKD. Fasting blood samples were also drawn for determination of calcium, phosphorus, parathyroid hormone, bone alkaline phosphatase, and 25-OH vitamin D.

Results
Median GFR was 66.5 (interquartile range, 40.0–88.3) ml/min per 1.73 m2. Median sclerostin level was 53.5 (interquartile range, 37.5–77.2) pmol/L, was higher in patients with a GFR <60 ml/min per 1.73 m2, and was highest in those with ESRD. Sclerostin levels were significantly more elevated in men than women (P<0.05). An inverse relationship was found between sclerostin and GFR (r=−0.58; P<0.001), and a positive correlation was seen with age (r=0.34; P<0.01) and serum phosphate (r=0.26; P=0.02). In multiple regression analyses, GFR, sex, and serum phosphate were the only variables associated with serum sclerostin (P<0.001). Age lost its relationship with sclerostin level.

Conclusions
This is the first study reporting higher serum sclerostin levels starting at CKD stage III. GFR, sex, and serum phosphate were the only measures associated with sclerostin level, suggesting that the effect of age reported in the literature might instead be attributable to the altered renal function in the elderly. Correcting the serum phosphorus level may be associated with lower sclerostin levels.
Impact of Probiotic on the Number of Lactic Acid Rods Forming Hydrogen Peroxide Isolated From Porkers and on Changes in Drug Resistance of Selected Escherichia Coli Isolates
Authors: Selwet Marek , Galbas Mariola , Dullin Piotr 
Published: February 2013

Abstract
The presented investigations were conducted on a group of 60 porkers of crossbreed Polish Landrace x Large White Polish. The animals were divided into two equal experimental groups. The control group (K) was fed diets without supplementation with probiotics, group (P) - diets with the addition of probiotic (0.2 kg t-1 feed). The aim of the study was to determine the effect of probiotic preparation on total numberof lactic acid rods from the Lactobacillus genus and those forming hydrogen oxide. The second part of experiment concerned the influence of probiotic preparation on the number, haemolytic ability and changes in drug resistance of Escherichia coli isolated from animal faeces. The significantly highest number of Lactobacillus sp. were determined in the saliva of porkers fed diets with the addition of probiotic, while the lowest in the control group. Lactobacillus sp. rods capable of forming hydrogen peroxide were isolated from 17 animals in group K and from three animals in group P. E. coli was determined in each examined sample of faeces. In groups K and P, counts of these bacteria were similar and did not differ statistically. High numbers of haemolytic isolates (haemolysis β) were found in faeces of animals fed diets with the addition of probiotic. Number and proportions of resistant isolates in groups K and P were different. Gentamicin was characterised by exceptionally high in vitro effectiveness. The used probiotic increased drug resistance of E. coli and increased frequency of incidence of haemolysis β.
Prevalence of Tick-Borne Encephalitis Virus Antibodies in Domestic and Game Animals from Eastern Poland
Authors: Cisak Ewa , Wójcik-Fatla Angelina , Sroka Jacek , Zając Violetta , Bilska-Zając Ewa , Chmurzyńska Ewa , Dutkiewicz Jacek 
Published: February 2013

Abstract
Serum samples from 123 cattle, 95 wild boars, and 43 deer (red deer, roe deer, and fallow deer) from the territory of eastern Poland were examined by the ELISA for the presence of specific antibodies against tick-borne encephalitis virus (TBEV). The rates of positive response in the animals were 4.1%, 16.8%, and 11.6%, respectively. Examination of 37 blood samples from deer with RT-PCR revealed only one positive result in a roe deer (2.7%). The relatively high serologic response rate in wild boars was due to a very high response rate (35.7%) in the Chełm district, which accounted for 94% of the total positive results. These findings seem to indicate that the Chełm district is most probably an endemic area of TBEV.
Effects of Iletamine-Zolazepam-Xylazine-Tramadol Combination on Biochemical and Haematological Parameters in Cats
Authors: Li Lin , Dong Jing , Lu Dezhang , Jiang Sheng , Lin Dongqi , Fan Honggang 
Published: February 2013

Abstract
Cats were injected with 2.4 mg/kg of tiletamine-zolazepam, 0.36 mg/kg of xylazine, and 0.8 mg/kg of tramadol, then blood was collected from their peripheral veins at 0.5, 1, 4, 8, 24, 48, 72, and 168 h after the injection. Before injection, the same cats were used as control group (0 h). Biochemical and haematological parameters were measured. The results revealed that the combination of the compounds produced good immobilisation, with minimal changes over time in biochemical and haematological parameters, which were within biologically acceptable limits.
Magnetic Resonance Imaging as a Useful Tool for the Selection of Pharmacological and Surgical Treatment Options for Canine Hydrocephalus
Authors: Pomianowski Andrzej , Adamiak Zbigniew 
Published: February 2013

Abstract
A group of 12 dogs, eight of small breeds and four of medium-sized breeds, were used in the study. Prior to the magnetic resonance imaging (MRI) scans, all dogs were subjected to neurological, laboratory, and electroencephalographic examinations, and trans-fontanel ultrasonography was additionally performed in two patients. The acquired obstructive hydrocephalus was diagnosed in two dogs, idiopathic obstructive hydrocephalus - in four patients, obstructive congenital hydrocephalus - in five dogs, and hydrocephalus ex vacuo- in one patient. Ten dogs were put under the pharmacological therapy, and in two patients the condition was treated surgically. MRI proved to be a valuable tool that supports selection of the appropriate pharmacological and surgical treatment. MRI scans also appear to be useful in monitoring an effectiveness of the applied form of treatment.
Diversity of GAG Gene Sequence Encoding Immunodominant Epitope on Capsid Protein of Lentiviruses from Sheep in Poland
Authors: Olech Monika , Rola-Łuszczak Marzena , Kozaczyńska Bożenna , Kubiś Piotr , Pluta Aneta , Gil Anna , Kuźmak Jacek 
Published: February 2013

Abstract
In the study, a 122 bp fragment of gag gene encoding immunodominant epitope on capsid protein of small ruminant lentiviruses (SRLVs) found in sheep was amplified by PCR and analysed by SSCP and sequencing. Out of 30 DNA samples, five showed different migration patterns, demonstrating the individual variations within gag sequences, which were confirmed afterwards by sequence analysis. In two samples nucleotide changes yielded amino acid substitutions highlighting the conservative nature of gag encoded immunoreactive epitope but also potencial insensitivity of a single-strain-based immunoassay.
Amygdalohippocampotomy: surgical technique and clinical results
Authors: Gonçalves-Ferreira Antonio , Campos Alexandre Rainha , Herculano-Carvalho Manuel , Pimentel Jose , Bentes Carla , Peralta Ana Rita , Morgado Carlos , _ _ 
Published: February 2013

Object
The removal of mesial temporal structures, namely amygdalohippocampectomy, is the most efficient surgical procedure for the treatment of epilepsy. However, disconnection of the epileptogenic zones, as in temporal lobotomy or, for different purposes, hemispherotomy, have shown equivalent results with less morbidity. Thus, authors of the present study began performing selective amygdalohippocampotomy in cases of refractory mesial temporal lobe epilepsy (TLE) to treat mesial temporal lobe sclerosis (MTLS).

Method
The authors conducted a retrospective analysis of all cases of amygdalohippocampotomy collected in a database between November 2007 and March 2011.

Results
Since 2007, 21 patients (14 males and 7 females), ages 20–58 years (mean 41 years), all with TLE due to MTLS, were treated with selective ablation of the lateral amygdala plus perihippocampal disconnection (anterior one-half to two-thirds in dominant hemisphere), the left side in 11 cases and the right in 10. In 20 patients the follow-up was 2 or more years (range 24–44 months, average 32 months). Clinical outcome for epilepsy 2 years after surgery (20 patients) was good/very good in 19 patients (95%) with an Engel Class I (15 patients [75%]) or II outcome (4 patients [20%]) and bad in 1 patient (5%) with an Engel Class IV outcome (extratemporal focus and later reoperation).
Surgical morbidity included hemiparesis (capsular hypertensive hemorrhage 24 hours after surgery, 1 patient), verbal memory worsening (2 patients), and quadrantanopia (permanent in 2 patients, transient in 1). Late psychiatric depression developed in 3 cases. Operative time was reduced by about 30 minutes (15%) on average with this technique.

Conclusions
Amygdalohippocampotomy is as effective as amygdalohippocampectomy to treat MTLS and is a potentially safer, time-saving procedure.
La France dans le marché mondial du jeu vidéo
Authors: Gaume Nicolas 
Published: February 2013

Résumé En quarante ans, l’usage des nouvelles technologies a bouleversé notre manière de communiquer et de nous informer. De la télévision et téléphone fixe à l’internet et au mobile, notre rapport au temps et aux autres n’est plus le même. Concomitamment la place des loisirs dans nos sociétés industrielles n’a pas cessé de se développer. Et notre façon de nous divertir a elle aussi profondément muté. Celle ci a été marquée par l’essor considérable de la pratique du jeu vidéo. D’un marché balbutiant il y a quarante ans, le jeu vidéo représente cette année en France le premier marché du divertissement pas son chiffre d’affaires. La France, pays de consommation indéniable, est également un pays de production. Quel est sa place dans la compétition mondiale ? Quelles aventures entrepreneuriales ont su y prospérer ? Quels sont les leviers et freins propres à notre pays? Nous tenterons ici de vous donner des clefs de compréhension de ce loisir, de notre marché, de nos atouts et nos handicaps, notamment dans les bouleversements en cours portés par le jeu vidéo mobile et social.
De la démolition des taudis à la sauvegarde du patrimoine bâti (Montréal, 1954-1973)
Authors: Drouin Martin 
Published: February 2013

En 1954, le dépôt du plan Dozois prévoyait l’élimination d’une zone de taudis en vue de la construction du projet d’habitation sociale connue sous le nom des Habitations Jeanne-Mance. En se lançant dans une telle opération, la Ville de Montréal posait un premier geste concret pour enrayer un mal qui affectait les quartiers centraux : la dépréciation du cadre bâti ancien. Le geste peut également s’inscrire dans la genèse d’un mouvement pour la conservation du patrimoine. En explorant l’histoire de l’aménagement urbain à Montréal jusqu’à la création de l’association Sauvons Montréal en 1973, il est possible d’observer la transformation du regard posé sur l’environnement bâti. La juxtaposition des notions de taudis et de patrimoine permet en effet de se placer au coeur d’une mutation qui transforma radicalement la manière d’aménager la ville.
Anti–Melanoma Differentiation–Associated Protein 5–Associated Dermatomyositis: Expanding the Clinical Spectrum
Authors: Hall John C. , Casciola‐Rosen Livia , Samedy Lesly‐Ann , Werner Jessie , Owoyemi Kristie , Danoff Sonye K. , Christopher‐Stine Lisa 
Published: February 2013

ObjectiveAutoantibodies against melanoma differentiation–associated protein 5 (MDA‐5) have been described in several Asian dermatomyositis (DM) cohorts, often associated with amyopathic DM and rapidly progressive interstitial lung disease (ILD). A recent study of a DM cohort seen at a US dermatology clinic reports that MDA‐5 autoantibodies are associated with a unique cutaneous phenotype. Given the widening spectrum of clinical findings, we evaluated the clinical features of anti–MDA‐5–positive patients seen at a US myositis referral center.MethodsOne hundred sixty DM patients were screened for MDA‐5 autoantibodies by immunoprecipitation and antibody titers were analyzed in longitudinal serum samples. Anti–MDA‐5–positive patients were evaluated for the presence of additional myositis autoantibodies. Patient clinical characteristics were compared by retrospective chart review.ResultsMDA‐5 was targeted in 11 (6.9%) of 160 patients with DM. Of these, 9 presented with a symmetric polyarthropathy, 6 demonstrated overt clinical myopathy, and 8 had ILD. Eight anti–MDA‐5–positive patients exhibited the clinical attributes of the antisynthetase syndrome in the absence of Jo‐1 or other antisynthetase autoantibodies. MDA‐5 autoantibody titers did not correlate with clinical course.ConclusionMDA‐5 autoantibodies are found in DM patients presenting with a symmetric polyarthritis, clinically similar to rheumatoid arthritis. These patients often have features of the antisynthetase syndrome, but in the absence of antisynthetase autoantibodies. Most anti–MDA‐5–positive patients had overt clinical myopathy and ILD. The latter, while occasionally severe, typically resolved with immunosuppressive therapy. In this cohort, the MDA‐5 phenotype is frequently a clinical mimic of the antisynthetase syndrome and is not associated with rapidly progressive ILD.