bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding supplier structural embeddedness: A social network perspective
Authors: Kim Dong‐Young 
Published: April 2014

AbstractDespite a significant amount of attention, the potential of supplier structural embeddedness (i.e., the value of the structural position in an extended network) to improve the performance of a buying firm remains poorly understood. This study drew on the social network theory to empirically examine a conceptual framework specifying a relationship between the efforts of a buying firm to understand supplier structural configuration and operational and financial performance. This study also examines how the comprehension of structural embeddedness is transformed into performance for a buying firm through relational embeddedness (i.e., the strength of a dyadic relationship). Survey data collected from companies in the U.S. were analyzed using hierarchical regression analysis. The results indicate that the understanding of the structural dimension does help to enhance operational performance of a buying firm, but it does not lead to better financial performance. Empirical evidence shows that a buying firm does improve the quality of a dyadic relationship between the buying firm and a supplier by understanding how the supplier is connected to other firms and what positional values are produced. Further, relational embeddedness is found to mediate the influence of the enhanced understanding of the structural configuration on operational performance.
Protective effect of chitosan treatment against acetaminophen‐induced hepatotoxicity
Authors: Ozcelik Eda , Uslu Sema , Erkasap Nilufer , Karimkhani Hadi 
Published: April 2014

AbstractAcetaminophen (APAP) is the most commonly reported toxic ingestion in the world. Severe liver injury resulting from overdose or chronic use of APAP remains a significant clinical problem. In recent years, the mechanisms underlying liver injury caused by APAP have become much better understood. We have studied the protective effect of chitosan supplementation against APAP‐induced hepatotoxicity with respect to changes in the levels of total and lipid‐bound sialic acid in the serum and in the liver tissue and changes in the activity of diagnostic marker enzymes, lipid peroxidation, and ceruloplasmin oxidase enzyme in normal and experimental groups of rats. During the experimental period, chitosan (200 mg/kg body weight per day) was administered to APAP + chitosan‐treated rats by oral gavage. Results showed that treatment with APAP induced a significant increase in the serum alanine aminotransferase and alkaline phosphatase activities, in total and lipid‐bound sialic acids levels, and in the liver lipid peroxide content. The administration of chitosan significantly prevented APAP‐induced alterations in the levels of diagnostic marker enzymes, total sialic acid, lipid‐bound sialic acid, and malondialdehyde in the experimental groups of rats. Furthermore, chitosan administration increased the activity of ceruloplasmin oxidase. In conclusion, our results suggest that chitosan has a protective effect on APAP‐induced hepatic injury in rats. The study sheds light on the therapeutic potential of chitosan in an APAP‐induced hepatotoxicity model.
Analytical solutions of compacting flow past a sphere
Authors: Rudge John F. 
Published: April 2014

AbstractA series of analytical solutions are presented for viscous compacting flow past a rigid impermeable sphere. The sphere is surrounded by a two-phase medium consisting of a viscously deformable solid matrix skeleton through which a low-viscosity liquid melt can percolate. The flow of the two-phase medium is described by McKenzie’s compaction equations, which combine Darcy flow of the liquid melt with Stokes flow of the solid matrix. The analytical solutions are found using an extension of the Papkovich–Neuber technique for Stokes flow. Solutions are presented for the three components of linear flow past a sphere: translation, rotation and straining flow. Faxén laws for the force, torque and stresslet on a rigid sphere in an arbitrary compacting flow are derived. The analytical solutions provide instantaneous solutions to the compaction equations in a uniform medium, but can also be used to numerically calculate an approximate evolution of the porosity over time whilst the porosity variations remain small. These solutions will be useful for interpreting the results of deformation experiments on partially molten rocks.
Prodromal dementia with Lewy bodies
Authors: Donaghy P. C. , O'Brien J. T. , Thomas A. J. 
Published: April 2014

BackgroundThe clinical condition of dementia is now recognized as a diagnosis that can only be applied too late in the disease process to be useful for therapeutic approaches centring on disease modification. As a result, in recent years increasing attention has been given to mild cognitive impairment (MCI) and the diagnosis of prodromal dementia. This paper reviews the evidence for the clinical presentation of prodromal dementia with Lewy bodies (DLB).MethodA Medline search was carried out to identify articles with original data on the prodromal presentation of DLB.ResultsIn MCI cohorts that progress to dementia, the proportion diagnosed with DLB is similar to that reported in dementia cohorts. Prodromal DLB may present as any MCI subtype, although visuospatial and executive domains may be most commonly affected. Rapid eye movement (REM) sleep behaviour disorder (RBD), autonomic symptoms, hyposmia, hallucinations and motor symptoms seem to be more common in prodromal DLB than in prodromal Alzheimer's disease (AD). Some of these symptoms can precede the diagnosis of DLB by several years. There has been little research into the use of biomarkers in prodromal DLB, although in RBD cohorts, clinical and imaging biomarkers have been associated with the development of DLB.ConclusionsThe evidence available suggests that prodromal DLB may be differentiated from other dementia prodromes in most cases. Further research is needed to confirm this, and to assess the utility of biomarkers such as 123I-FP-CIT and 123I-MIBG imaging.
Fallenness and anhypostasis: a way forward in the debate over Christ's humanity
Authors: Sumner Darren O. 
Published: April 2014

AbstractThe doctrine of the incarnation suggests that Christ is necessarily like us in some respects, and also unlike us in others. One long-standing debate in modern christology concerns whether Jesus’ human nature ought to be regarded as ‘fallen’ – as conditioned by the effects of the Fall – despite the fact that he himself remained without sin (Heb 4:15). Is fallenness a condition which is necessary in order for Christ to sympathise with human beings, to represent them, and so to reconcile them to God? Is fallenness logically separable from sinfulness? Recent literature has suggested an increasing intractability on both sides of this debate. This article seeks to bring clarity to the question of the fallenness of Christ's human nature by identifying areas of common ground between advocates and opponents of this position. It engages the work of representatives from both sides – Oliver Crisp in opposition and Karl Barth in support – in order to determine the different ways in which they approach the matter of Jesus’ fallenness and impeccability, and to locate points of potential consensus. Crisp argues that fallenness cannot be detached from sin and guilt – i.e. Augustine's notion of both original sin and original corruption, in which sin is an inevitability. Barth, on the other hand, is critical of the Augustinian view and takes as his point of departure Jesus’ unity and sympathy with fallen creatures. Yet the fallenness of Jesus’ humanity does not mean that sin was a real possibility for him.In this article the christological doctrine of anhypostasis – a way of speaking exclusively of human nature apart from its hypostatic union with God the Son – is suggested as the primary way forward. Advocates of the fallenness position seem to have this qualifier in mind when describing Jesus’ human nature as ‘fallen’: it is true of the assumed nature only when considered in itself, apart from the hypostatic union. There are logical and historical grounds for opponents to accept fallenness strictly on these terms, as well. Beyond this, I argue that anhypostatic fallenness should be acceptable to both sides because it is never without a corresponding sanctification of Jesus’ human nature by its encounter with God. Though Jesus’ humanity was conditioned by the fall, by virtue of the communicatio gratiarum it was not left in a state of peccability.
Psalm 2:7 and the concept of περιχώρησις
Authors: Straus Michael 
Published: April 2014

AbstractThis article takes as its springboard the well-known text of Psalm 2:7, in which the Psalmist – presumably David, king of Israel – refers to himself as a ‘begotten’ son of God by virtue of his Lord's decree. The article first explores various linguistic and theological options as to the identity of the ‘son’ to whom the passage refers; and analyses the relationship between that son and the one who is stated to have begotten him. In this context, the article addresses ways in which the passage more generally sheds light on the relationship between God and Israel, including through analysis of a number of fluctuating usages of singular and plural terms in the Old Testament to describe that relationship. Second, and against that background, the article examines texts in the New Testament which quote or refer to Psalm 2:7 to see whether they provide a better understanding of the nature of the relationship between the father and the son described in the Psalm; and further to see whether any enhanced understanding of that relationship reciprocally sheds light on the relationship of God the Father to God the Son as revealed in the New Testament. The article then seeks to determine whether these passages, taken as a whole, provide explicit, implicit, or proto-Trinitarian concepts in anticipation of those given fuller expression in orthodox Church doctrine. Finally, the article explores the concept of circumincession, or coinherence, John of Damascus’ highly abstracted and nearly poetic effort at the close of the Patristic era to provide an extra-biblical explanation of the relationship between the Father and the Son as well as the relationship among the three members of the Trinity. The article concludes by finding that his attempted articulation, and quite possibly all such efforts, will ultimately fail, leaving intact the mystery of the Trinity as one escaping, or rather surpassing, conceptual analysis.
The influence of galactic cosmic rays on ion–neutral hydrocarbon chemistry in the upper atmospheres of free-floating exoplanets
Authors: Rimmer P. B. , Helling Ch. , Bilger C. 
Published: April 2014

AbstractCosmic rays may be linked to the formation of volatiles necessary for prebiotic chemistry. We explore the effect of cosmic rays in a hydrogen-dominated atmosphere, as a proof-of-concept that ion–neutral chemistry may be important for modelling hydrogen-dominated atmospheres. In order to accomplish this, we utilize Monte Carlo cosmic ray transport models with particle energies of 106 eV<E<1012 eV in order to investigate the cosmic-ray enhancement of free electrons in substellar atmospheres. Ion–neutral chemistry is then applied to a Drift–Phoenix model of a free-floating giant gas planet. Our results suggest that the activation of ion–neutral chemistry in the upper atmosphere significantly enhances formation rates for various species, and we find that C2H2, C2H4, NH3, C6H6 and possibly C10H are enhanced in the upper atmospheres because of cosmic rays. Our results suggest a potential connection between cosmic-ray chemistry and the hazes observed in the upper atmospheres of various extrasolar planets. Chemi-ionization reactions are briefly discussed, as they may enhance the degree of ionization in the cloud layer.
The Perceived Stress Scale (PSS): Normative Data and Factor Structure for a Large-Scale Sample in Mexico
Authors: González-Ramírez Mónica Teresa , Rodríguez-Ayán María Noel , Hernández René Landero 
Published: April 2014

AbstractOne of the most widely used scales for the evaluation of stress is the Perceived Stress Scale (PSS), and it has been adapted into different languages. However, few studies have presented normative data from large samples, and there do not appear to be any studies of the PSS that provide normative data based on large samples for Mexico. Thus, the goal of this study was to provide normative data regarding gender and different age groups for a sample of 1990 Mexican subjects to validate the factor structure of the construct for this sample. The analysis of the 10- and 14-item versions of the PSS revealed that the scale had adequate reliability and that the factor structure was consistent with previous studies. With respect to the normative data, the means of the different groups ranged from 20.93 to 25.63 for the PSS14 and from 14.52 to 17.73 for the PSS10. We propose that scores within one standard deviation of these means be used as reference values for each group.
Density of founder cells affects spatial pattern formation and cooperation in Bacillus subtilis biofilms
Authors: van Gestel Jordi , Weissing Franz J , Kuipers Oscar P , Kovács Ákos T 
Published: April 2014

Abstract
In nature, most bacteria live in surface-attached sedentary communities known as biofilms. Biofilms are often studied with respect to bacterial interactions. Many cells inhabiting biofilms are assumed to express ‘cooperative traits’, like the secretion of extracellular polysaccharides (EPS). These traits can enhance biofilm-related properties, such as stress resilience or colony expansion, while being costly to the cells that express them. In well-mixed populations cooperation is difficult to achieve, because non-cooperative individuals can reap the benefits of cooperation without having to pay the costs. The physical process of biofilm growth can, however, result in the spatial segregation of cooperative from non-cooperative individuals. This segregation can prevent non-cooperative cells from exploiting cooperative neighbors. Here we examine the interaction between spatial pattern formation and cooperation in Bacillus subtilis biofilms. We show, experimentally and by mathematical modeling, that the density of cells at the onset of biofilm growth affects pattern formation during biofilm growth. At low initial cell densities, co-cultured strains strongly segregate in space, whereas spatial segregation does not occur at high initial cell densities. As a consequence, EPS-producing cells have a competitive advantage over non-cooperative mutants when biofilms are initiated at a low density of founder cells, whereas EPS-deficient cells have an advantage at high cell densities. These results underline the importance of spatial pattern formation for competition among bacterial strains and the evolution of microbial cooperation.
Scaling behaviour for the water transport in nanoconfined geometries
Authors: Chiavazzo Eliodoro , Fasano Matteo , Asinari Pietro , Decuzzi Paolo 
Published: April 2014

AbstractThe transport of water in nanoconfined geometries is different from bulk phase and has tremendous implications in nanotechnology and biotechnology. Here molecular dynamics is used to compute the self-diffusion coefficient D of water within nanopores, around nanoparticles, carbon nanotubes and proteins. For almost 60 different cases, D is found to scale linearly with the sole parameter θ as D(θ)=DB[1+(DC/DB−1)θ], with DB and DC the bulk and totally confined diffusion of water, respectively. The parameter θ is primarily influenced by geometry and represents the ratio between the confined and total water volumes. The D(θ) relationship is interpreted within the thermodynamics of supercooled water. As an example, such relationship is shown to accurately predict the relaxometric response of contrast agents for magnetic resonance imaging. The D(θ) relationship can help in interpreting the transport of water molecules under nanoconfined conditions and tailoring nanostructures with precise modulation of water mobility.
Ultrabroadband direct detection of nonclassical photon statistics at telecom wavelength
Authors: Wakui Kentaro , Eto Yujiro , Benichi Hugo , Izumi Shuro , Yanagida Tetsufumi , Ema Kazuhiro , Numata Takayuki , Fukuda Daiji , Takeoka Masahiro , Sasaki Masahide 
Published: April 2014

AbstractBroadband light sources play essential roles in diverse fields, such as high-capacity optical communications, optical coherence tomography, optical spectroscopy and spectrograph calibration. Although a nonclassical state from spontaneous parametric down-conversion may serve as a quantum counterpart, its detection and characterization have been a challenging task. Here we demonstrate the direct detection of photon numbers of an ultrabroadband (110 nm FWHM) squeezed state in the telecom band centred at 1535 nm wavelength, using a superconducting transition-edge sensor. The observed photon-number distributions violate Klyshko's criterion for the nonclassicality. From the observed photon-number distribution, we evaluate the second- and third-order correlation functions and characterize a multimode structure, which implies that several tens of orthonormal modes of squeezing exist in the single optical pulse. Our results and techniques open up a new possibility to generate and characterize frequency-multiplexed nonclassical light sources for quantum info-communications technology.
Magnetic Field Tunable Small-scale Mechanical Properties of Nickel Single Crystals Measured by Nanoindentation Technique
Authors: Zhou Hao , Pei Yongmao , Fang Daining 
Published: April 2014

AbstractNano- and micromagnetic materials have been extensively employed in micro-functional devices. However, measuring small-scale mechanical and magnetomechanical properties is challenging, which restricts the design of new products and the performance of smart devices. A new magnetomechanical nanoindentation technique is developed and tested on a nickel single crystal in the absence and presence of a saturated magnetic field. Small-scale parameters such as Young's modulus, indentation hardness and plastic index are dependent on the applied magnetic field, which differ greatly from their macroscale counterparts. Possible mechanisms that induced 31% increase in modulus and 7% reduction in hardness (i.e., the flexomagnetic effect and the interaction between dislocations and magnetic field, respectively) are analyzed and discussed. Results could be useful in the microminiaturization of applications, such as tunable mechanical resonators and magnetic field sensors.
Comparison of Speech Recognition With Adaptive Digital and FM Remote Microphone Hearing Assistance Technology by Listeners Who Use Hearing Aids
Authors: Thibodeau Linda 
Published: April 2014

Purpose
The purpose of this study was to compare the benefits of 3 types of remote microphone hearing assistance technology (HAT), adaptive digital broadband, adaptive frequency modulation (FM), and fixed FM, through objective and subjective measures of speech recognition in clinical and real-world settings.

Method
Participants included 11 adults, ages 16 to 78 years, with primarily moderate-to-severe bilateral hearing impairment (HI), who wore binaural behind-the-ear hearing aids; and 15 adults, ages 18 to 30 years, with normal hearing. Sentence recognition in quiet and in noise and subjective ratings were obtained in 3 conditions of wireless signal processing.

Results
Performance by the listeners with HI when using the adaptive digital technology was significantly better than that obtained with the FM technology, with the greatest benefits at the highest noise levels. The majority of listeners also preferred the digital technology when listening in a real-world noisy environment. The wireless technology allowed persons with HI to surpass persons with normal hearing in speech recognition in noise, with the greatest benefit occurring with adaptive digital technology.

Conclusion
The use of adaptive digital technology combined with speechreading cues would allow persons with HI to engage in communication in environments that would have otherwise not been possible with traditional wireless technology.
No Learning Effect Observed for Reception Thresholds for Sentences in Noise
Authors: Stuart Andrew , Butler Alyson K. 
Published: April 2014

Purpose

This study examined reception thresholds for sentences (RTSs) as a function of test session (
N
= 5) and noise (continuous and interrupted) in normal-hearing adults. It was hypothesized that RTSs would be superior in interrupted noise and would be stable across repeated testing.

Method
Twenty-five normal-hearing adults participated. RTSs were determined with Hearing in Noise Test sentences in continuous and interrupted noise presented at 65 dBA. An adaptive technique was used where sentences varied in intensity to converge on a level of 50% of correct performance. Sentence lists were counterbalanced with 5 unique lists in both continuous and interrupted noise.

Results

RTS signal-to-noise ratios were significantly better in the interrupted noise (
p
< .0001). There was no effect of test session (
p
= .12) or a Test Session × Noise interaction (
p
= .13).

Conclusions
Stable RTS signal-to-noise ratios across test sessions in both noises are consistent with the notion that a learning effect was not present in noise. Further, one may conclude that Hearing in Noise Test sentences provide stable measures of sentence recognition thresholds in normal-hearing adults over time so long as sentences are unique or are not repeated.
The docking protein FRS2α is a critical regulator of VEGF receptors signaling
Authors: Chen Pei-Yu , Qin Lingfeng , Zhuang Zhen W. , Tellides George , Lax Irit , Schlessinger Joseph , Simons Michael 
Published: April 2014

Significance
Regulation of vascular endothelial growth factor (VEGF) signaling plays a central role in a range of biological processes from embryonic and perinatal vascular development to maintenance of the mature adult vasculature to regulation of various organs function. We report that the intracellular docking protein FRS2α, not hitherto known to be involved in VEGF signaling, plays a critical role in regulation of this process.
SECA: SNP effect concordance analysis using genome-wide association summary results
Authors: Nyholt Dale R. 
Published: April 2014

Abstract
Summary: The genomics era provides opportunities to assess the genetic overlap across phenotypes at the measured genotype level; however, current approaches require individual-level genome-wide association (GWA) single nucleotide polymorphism (SNP) genotype data in one or both of a pair of GWA samples. To facilitate the discovery of pleiotropic effects and examine genetic overlap across two phenotypes, I have developed a user-friendly web-based application called SECA to perform S NP e ffect c oncordance a nalysis using GWA summary results. The method is validated using publicly available summary data from the Psychiatric Genomics Consortium.
Availability and implementation: http://neurogenetics.qimrberghofer.edu.au/SECA .
Contact: dale.nyholt@qimrberghofer.edu.au
Supplementary information: Supplementary data are available at Bioinformatics online.