bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatty acid synthesis is indispensable for Kupffer cells to eliminate bacteria in ALD progression
Authors: Xie Liuyu , Wu Beng , Fan Yuanyuan , Tao Ye , Jiang Xiaoyong , Li Qing , Zhu Huaiping , Wang Hua , Hu Chaojie 
Published: August 2024

Background:
Dysregulated fatty acid metabolism is closely linked to the development of alcohol-associated liver disease (ALD). KCs, which are resident macrophages in the liver, play a critical role in ALD pathogenesis. However, the effect of alcohol on fatty acid metabolism in KCs remains poorly understood. The current study aims to investigate fatty acid metabolism in KCs and its potential effect on ALD development.

Methods:
Wild-type C57BL/6 mice were fed a Lieber-DeCarli ethanol liquid diet for 3 days. Then, the liver injury and levels of intrahepatic bacteria were assessed. Next, we investigated the effects and underlying mechanisms of ethanol exposure on fatty acid metabolism and the phagocytosis of KCs, both in vivo and in vitro. Finally, we generated KCs-specific Fasn knockout and overexpression mice to evaluate the impact of FASN on the phagocytosis of KCs and ethanol-induced liver injury.

Results:
Using Bodipy493/503 to stain intracellular neutral lipids, we found significantly reduced lipid levels in KCs from mice fed an alcohol-containing diet for 3 days and in RAW264.7 macrophages exposed to ethanol. Mechanistically, alcohol exposure suppressed sterol regulatory element-binding protein 1 transcriptional activity, thereby inhibiting fatty acid synthase (FASN)-mediated de novo lipogenesis in macrophages both in vitro and in vivo. We show that genetic ablation and pharmacologic inhibition of FASN significantly impaired KC’s ability to take up and eliminate bacteria. Conversely, KCs-specific Fasn overexpression reverses the impairment of macrophage phagocytosis caused by alcohol exposure. We also revealed that KCs-specific Fasn knockout augmented KCs apoptosis and exacerbated liver injury in mice fed an alcohol-containing diet for 3 days.

Conclusions:
Our findings indicate the crucial role of de novo lipogenesis in maintaining effective KCs phagocytosis and suggest a therapeutic target for ALD based on fatty acid synthesis in KCs.
Real-world risk factors for herpes zoster in patients with rheumatoid arthritis undergoing tofacitinib treatment
Authors: Sun Yi-Syuan , Huang De-Feng , Chen Wei-Sheng , Liao Hsien-Tzung , Chen Ming-Han , Tsai Hung-Cheng , Tsai Ming-Tsun , Tsai Chang-Youh , Lai Chien-Chih , Yang Chih-Yu 
Published: August 2024

Background:
This study sought to assess the risk factors of herpes zoster (HZ) in rheumatoid arthritis (RA) patients treated with tofacitinib (TOFA).

Methods:
This retrospective study reviewed RA patients receiving TOFA. We compared clinical characteristics, laboratory profiles, concomitant medication use, and HZ incidence in patients with and without recent biologic synthetic disease-modifying antirheumatic drugs (bDMARDs) treatment, which is defined as their administration ≤180 days before the initiation of TOFA treatment. We used univariate Cox proportional hazards models and Kaplan-Meier analysis to assess risk factors.

Results:
Among 304 RA patients, 97 had recent bDMARDs use and 207 did not. Patients with recent bDMARDs use typically had lower weekly doses of methotrexate, less hydroxychloroquine use, and shorter follow-up. In the recent bDMARDs group, 64 (66.0%) used tumor necrosis factor inhibitors (TNFi), 19 (19.6%) used tocilizumab, and 14 (14.4%) used abatacept. The overall incidence rate (IR) of HZ was 5.62 per 100 person-years. Patients with recent bDMARDs use exhibited a higher HZ risk compared to those without recent bDMARDs use (IR ratio: 2.34, 95% CI, 1.04-5.19, p = 0.028). Recent bDMARDs use (hazard ratio: 2.4, 95% CI, 1.12-4.95, p = 0.024) was an independent risk factor for HZ among multivariable analysis. Kaplan-Meier analysis confirmed increased HZ risk in RA patients on TOFA with recent bDMARDs use (log-rank p = 0.015).

Conclusion:
HZ is common in RA patients treated with TOFA, and recent bDMARDs (TNFi, tocilizumab, and abatacept) use is a risk factor for HZ. HZ vaccination, therefore, should be recommended for this group.
Impact of aromatherapy on anxiety among ICU nurses
Authors: Hubbard Sandra , O'conner Kalyn , Lockhart Ellen Rachel , Carter Kimberly Ferren , Harvey Ellen 
Published: August 2024

Abstract

Purpose:
The purpose of this study was to examine the effect of aromatherapy with an essential oil blend containing lavender, bergamot, ylang-ylang, and sweet orange, compared with placebo, on perceptions of anxiety in ICU RNs.

Methods:
Nurses recruited from six adult ICUs and a neonatal ICU participated in this blinded, randomized, placebo-controlled study, which took place over a 30-day intervention period.

Results:
Although there were no statistically significant changes in anxiety pre- to postintervention or between the intervention and placebo groups, there were also no adverse events or untoward effects.

Conclusion:
The results of this study may support aromatherapy as an evidence-based strategy to reduce anxiety in ICU nurses. Additional research is needed.
How clinical resource nurses can support new nurses and address safety concerns
Authors: Nadeau Michelle , Madden Marissa W. , Glassman Emily L. 
Published: August 2024

Abstract:
Inexperienced nursing staff can jeopardize patient safety and contribute to burnout. This quality improvement project evaluated a clinical resource nurse (CRN) role designed to address disparities in nurses' skills and experience. Survey results suggested that the CRN role effectively supported novice nurses.
Maintenance Repetitive Transcranial Magnetic Stimulation for Major Depressive Disorder
Authors: Akram Salman , Nanji Imaan , Deniz Ismail , Akram Faisal , Mukhtar Fahad 
Published: August 2024

Abstract
Repetitive transcranial magnetic stimulation (rTMS) is an effective therapy for acute treatment of major depressive disorder (MDD). However, the efficacy and optimal strategy of delivering maintenance rTMS beyond acute treatment remains unclear. This meta-analysis aims to quantify the treatment effect of maintenance rTMS therapy in MDD and compares the difference in treatment effect between the fixed and rescue maintenance rTMS protocols. We conducted a meta-analysis of 14 studies (N = 705) comparing depression rating scores before and after maintenance rTMS. Standardized mean scores adjusted for sample size (Hedges g) were used as the effect size. Subgroup analysis was performed to compare the fixed and rescue maintenance rTMS treatment. Maintenance rTMS was associated with a statistically significant improvement in depression scores (standardized mean difference [SMD] = 0.75; confidence interval [CI] = −1.25 to −0.25). The random effects model had the Q value = 142.67 (P < 0.0001) and I
2 = 90%, supporting significant heterogeneity among studies. The prediction interval yielded a possible effect size from −2.54 to 1.05. The subgroup analysis showed a stronger treatment effect for rescue maintenance protocol (SMD = −1.17; CI = −2.13 to −0.21) compared to fixed maintenance protocol (SMD = −0.45; CI = −1.00.16). Although not statistically significant (Q-between = 2.56, df-between = 1, P = 0.1096), a large difference in effect size was observed between subgroups. Maintenance rTMS appears to be an effective strategy for maintaining remission and preventing relapse in MDD. Significant heterogeneity among the studies warrants caution in interpreting the results. These findings suggest the need for standard protocols and consensus guidelines for the optimal delivery of maintenance rTMS treatment.
Morphogenic, molecular, and cellular adaptations for unidirectional airflow in the chicken lung
Authors: Gerner-Mauro Kamryn N , Ellis Lisandra Vila , Wang Guolun , Nayak Richa , Lwigale Peter Y , Poché Ross A , Chen Jichao 
Published: August 2024

ABSTRACTUnidirectional airflow in the avian lung enables gas exchange during both inhalation and exhalation. The underlying developmental process and how it deviates from that of the bidirectional mammalian lung are poorly understood. Sampling key developmental stages with multiscale 3D imaging and single-cell transcriptomics, we delineate morphogenic, molecular, and cellular features that accommodate the unidirectional airflow in the chicken lung. Primary termini of hyper-elongated branches are eliminated via proximal-short and distal-long fusions, forming parabronchi. Neoform termini extend radially through parabronchial smooth muscle to form gas-exchanging alveoli. Supporting this radial alveologenesis, branch stalks halt their proximalization, defined by SOX9-SOX2 transition, and become SOX9lowparabronchi. Primary and secondary vascular plexi interface with primary and neoform termini, respectively. Single-cell and Stereo-seq spatial transcriptomics reveal a third, chicken-specific alveolar cell type expressing KRT14, hereby named luminal cells. Luminal, alveolar type 2, and alveolar type 1 cells sequentially occupy concentric zones radiating from the parabronchial lumen. Our study explores the evolutionary space of lung diversification and lays the foundation for functional analysis of species-specific genetic determinants.
Gender and speech material effects on the long-term average speech spectrum, including at extended high frequencies
Authors: Delaram Vahid , Miller Margaret K. , Ananthanarayana Rohit M. , Trine Allison , Buss Emily , Stecker G. Christopher , Monson Brian B. 
Published: August 2024

AbstractGender and language effects on the long-term average speech spectrum (LTASS) have been reported, but typically using recordings that were bandlimited and/or failed to accurately capture extended high frequencies (EHFs). Accurate characterization of the full-band LTASS is warranted given recent data on the contribution of EHFs to speech perception. The present study characterized the LTASS for high-fidelity, anechoic recordings of males and females producing Bamford-Kowal-Bench (BKB) sentences, digits, and unscripted narratives. Gender had an effect on spectral levels at both ends of the spectrum: males had higher levels than females below approximately 160 Hz, owing to lower fundamental frequencies; females had ∼4 dB higher levels at EHFs, but this effect was dependent on speech material. Gender differences were also observed at ∼300 Hz, and between 800-1000 Hz, as previously reported. Despite differences in phonetic content, there were only small, gender-dependent differences in EHF levels across speech materials. EHF levels were highly correlated across materials, indicating relative consistency within talkers. Our findings suggest that LTASS levels at EHFs are influenced primarily by talker and gender, highlighting the need for future research to assess whether EHF cues are more audible for female speech than for male speech.
The impact of carbon emission regulations on B2C car-sharing platforms’ operating models
Authors: Sun Changyong , Li Yiwen , Liu Yixuan 
Published: August 2024

PurposeAlthough the impact of carbon emissions regulations is evident to upstream automakers, their influence on downstream B2C car-sharing platforms remains unclear. This article reveals the influence of carbon emission regulations on the performance of supply chain members. In particular, we focused on the decision of B2C car-sharing platforms.Design/methodology/approachWe develop a three-stage dynamic game model consisting of an automaker, a B2C car-sharing platform and consumers.FindingsThe carbon emission cap has a critical threshold. Above this threshold, the regulation is ineffective for the platform’s operating model. Below it, the regulation affects the platform, moderated by customers' green awareness. The threshold initially decreases (weakly) and then increases in awareness. Effective caps reduce profits for the manufacturer, B2C car-sharing platform and supply chain, while ineffective caps see higher profits with increased awareness.Originality/valueFirstly, this paper explores the impact of carbon emission caps on the operational strategies of B2C car-sharing platforms within the sharing economy, complementing existing research. Secondly, it identifies conditions where stricter caps prompt B2C car-sharing platforms to adjust their operational models and offers fresh insights for managers and departments responsible for carbon emission policy formulation. Thirdly, the study uncovers how carbon emission caps affect the performance of supply chain members, providing crucial managerial insights for sustainable operations.
Enhancing patient safety using failure mode and effect criticality analysis: a benchmarking study on selected hospitals
Authors: Sarkar Niloy 
Published: August 2024

PurposePatient safety is a top priority globally. A robust healthcare system requires strategic collaboration between research and development. The author analysed over 300 cases from seven hospitals using the failure modes, effects, and criticality analysis (FMECA) tool to understand the underlying causes of medical errors.Design/methodology/approachThe author studied seven hospitals and 300 cases using FMECA to prioritise activities. The findings showed that high-priority events occurred less frequently but had the potential to cause the most harm. Team members evaluated independently to ensure unbiased evaluations. This approach is useful for setting priorities or assessing difficulties.FindingsPoor communication and lack of coordination among staff in a healthcare organisation caused misunderstandings, ineffective decision-making, delays in patient care, and medical errors. Implementation of effective communication and coordination protocols can help avoid these problems.Practical implicationsThe study recommends using FMECA to identify and prioritise failures and conducting in-depth analyses to understand their root causes. It also highlights the importance of interdisciplinary knowledge and soft skills for healthcare staff.Originality/valueThis study reveals the significance of FMECA in healthcare risk management and benchmarking. FMECA helps identify system failures, develop prevention strategies, and evaluate effectiveness against industry benchmarks. It offers healthcare professionals a valuable tool to enhance patient safety and improve healthcare quality.
Enablers of new business density: a comparison between developed and developing countries using deep learning and explainable AI
Authors: Pramanik Paritosh , Jana Rabin K. , Ghosh Indranil 
Published: August 2024

PurposeNew business density (NBD) is the ratio of the number of newly registered liability corporations to the working-age population per year. NBD is critical to assessing a country's business environment. The present work endeavors to discover and gauge the contribution of 28 potential socio-economic enablers of NBD for 2006–2021 across developed and developing economies separately and to make a comparative assessment between those two regions.Design/methodology/approachUsing World Bank data, the study first performs exploratory data analysis (EDA). Then, it deploys a deep learning (DL)-based regression framework by utilizing a deep neural network (DNN) to perform predictive modeling of NBD for developed and developing nations. Subsequently, we use two explainable artificial intelligence (XAI) techniques, Shapley values and a partial dependence plot, to unveil the influence patterns of chosen enablers. Finally, the results from the DL method are validated with the explainable boosting machine (EBM) method.FindingsThis research analyzes the role of 28 potential socio-economic enablers of NBD in developed and developing countries. This research finds that the NBD in developed countries is predominantly governed by the contribution of manufacturing and service sectors to GDP. In contrast, the propensity for research and development and ease of doing business control the NBD of developing nations. The research findings also indicate four common enablers – business disclosure, ease of doing business, employment in industry and startup procedures for developed and developing countries.Practical implicationsNBD is directly linked to any nation's economic affairs. Therefore, assessing the NBD enablers is of paramount significance for channelizing capital for new business formation. It will guide investment firms and entrepreneurs in discovering the factors that significantly impact the NBD dynamics across different regions of the globe. Entrepreneurs fraught with inevitable market uncertainties while developing a new idea into a successful new business can momentously benefit from the awareness of crucial NBD enablers, which can serve as a basis for business risk assessment.Originality/valueDL-based regression framework simultaneously caters to successful predictive modeling and model explanation for practical insights about NBD at the global level. It overcomes the limitations in the present literature that assume the NBD is country- and industry-specific, and factors of the NBD cannot be generalized globally. With DL-based regression and XAI methods, we prove our research hypothesis that NBD can be effectively assessed and compared with the help of global macro-level indicators. This research justifies the robustness of the findings by using the socio-economic data from the renowned data repository of the World Bank and by implementing the DL modeling with validation through the EBM method.
Being good by doing good: an analysis of audit fees, philanthropic initiatives and board gender diversity among Chinese listed firms
Authors: Zaid Mohammad A.A. , Issa Ayman 
Published: August 2024

Purpose
Despite the acknowledged significance of the relationship between audit fees and corporate philanthropic initiatives, the existing literature has not yet reached the desired level of providing explicit evidence on how this relationship can be moderated by board gender diversity. This paper aims to contribute to the ongoing debate by using a panel data set comprising 905 Chinese listed firms over a five-year period from 2015 to 2019.

Design/methodology/approach
To generate solid findings and overcome the potential endogeneity bias, various econometric estimators, namely, ordinary least squares, two-step generalized method of moments, robust two-stage least squares and subsample analysis, have been carefully used. More interestingly, the study’s results remain consistent across different estimation methods.

Findings
The results reveal a statistically significant positive link between audit fees and corporate charitable giving. More interestingly, this connection strengthens with a higher representation of women directors on the board, particularly when there are three or more female directors. Furthermore, the results suggest that nonstate-owned firms exhibit greater motivation to participate in charitable giving initiatives compared to state-owned counterparts.

Practical implications
Stakeholders from various groups should attentively recognize the importance of gender-diverse boards as a dynamic factor impacting the association between audit fees and corporate charitable giving.

Originality/value
To the best of the authors’ knowledge, the crushing majority of the preceding research has not delved deeply into the critical role of board gender diversity in the relationship between audit fees and corporate charitable donations. Hence, this study provides a profound understanding of how audit fees predict corporate philanthropic initiatives.
Beyond the resume: HR students’ evaluations of interview performances by first and second language speakers
Authors: Teló Cesar , Trofimovich Pavel , O'Brien Mary Grantham , Le Thao-Nguyen Nina , Bodea Anamaria 
Published: August 2024

PurposeHigh-stakes decision-makers, including human resource (HR) professionals, often exhibit accent biases against second language speakers in professional evaluations. We extend this work by investigating how HR students evaluate simulated job interview performances in English by first and second language speakers of English.Design/methodology/approachEighty HR students from Calgary and Montreal evaluated the employability of first language (L1) Arabic, English, and Tagalog candidates applying for two positions (nurse, teacher) at four points in the interview (after reading the applicant’s resume, hearing their self-introduction, and listening to each of two responses to interview questions). Candidates’ responses additionally varied in the extent to which they meaningfully answered the interview questions.FindingsStudents from both cities provided similar evaluations, employability ratings were similar for both advertised positions, and high-quality responses elicited consistently high ratings while evaluations for low-quality responses declined over time. All speakers were evaluated similarly based on their resumes and self-introductions, regardless of their language background. However, evaluations diverged for interview responses, where L1 Arabic and Tagalog speakers were considered more employable than L1 English speakers. Importantly, students’ preference for L1 Arabic and Tagalog candidates over L1 English candidates was magnified when those candidates provided low-quality interview responses.Originality/valueResults suggest that even in the absence of dedicated equity, diversity, and inclusion (EDI) training focusing on language and accent bias, HR students may be aware of second language speakers’ potential disadvantages in the workplace, rewarding them in the current evaluations. Findings also highlight the potential influence of contextual factors on HR students’ decision-making.
Negative emotions and marketing retrenchment during crisis: attribution effects through crisis severity and strategic orientations
Authors: Miocevic Dario 
Published: August 2024

Purpose
Emotions are widely acknowledged decision-making drivers, taking the front seat when managers lack objective information. Existing evidence indicates that negative emotions often lead to the decision to retrench. Contrary to these insights, our research aims to show that negative emotions can sometimes push top managers to withdraw from retrenching marketing activities. By drawing on the affect-as-information approach, this study aims to examine the direct and conditional effects of top managers’ negative emotions on small and medium-sized enteprises (SMEs’) intention to retrench marketing activities during the recent economic crisis caused by the COVID-19 pandemic.

Design/methodology/approach
This study uses a descriptive research design and surveys a sample of 155 chief executive officers from business-to-business (B2B) SMEs in Croatia. The authors empirically test the conceptual framework with hierarchical regression.

Findings
Based on the sample of 155 top managers of SMEs operating in B2B industries, negative emotions positively drive marketing retrenchment. However, additional insights reveal that this relationship is conditioned by crisis severity and SMEs' strategic orientations (exploration and exploitation). The relationship between negative emotions and marketing retrenchment weakens for SMEs severely hampered by the crisis and for SMEs following the exploitative orientation. In contrast, this relationship becomes stronger for SMEs whose business customers have been severely hampered and for SMEs following exploratory orientation.

Originality/value
This research advances the body of knowledge by demonstrating that, depending on the severity of the crisis and the strategic orientation of the SME, top managers may interpret negative emotions quite differently, which eventually has lasting consequences on marketing retrenchment during crises. Therefore, by focusing on emotional microfoundations and unique crisis- and firm-level contingencies, this study goes beyond existing theoretical discussions that contrast marketing retrenchment vs investment and offers a different understanding of why and when SMEs retrench their marketing activities during crises.