bluuebunny/crossref_metadata_2025_split huggingface dataset:
Children’s representations of the SARS-CoV-2 virus and associated pandemic experiences post-infection in China
Authors: Yang Daihu , Zhu Guilan , Guo Taofen , Zhou Minghui , Zhang Yan , Geng Ming , Cheng Xiaozhong 
Published: August 2024

Objective: This study examined children’s representations of the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) as well as their pandemic experiences against the backdrop of the world having transitioned to normalcy. Design: Mixed-methods approach encompassing both qualitative and quantitative analysis. Setting: Two middle schools in Hefei city in mid-eastern China. Method: Data were collected using a qualitative task which elicited children’s drawings, commentaries, answers to questions related to their pandemic experiences, followed by small-group interviews. Content analysis and emergent coding techniques were employed to analyse the data, the extracted themes of which were then quantified to reveal their incidence and distribution. Results: Analysis of the multimodal data set revealed children not only depicted viral morphology but also evoked emotions. The pandemic had brought about changes in children’s lives, marked by a shift towards more academic activities, rest and relaxation and screen time. These changes also raised psychological, physical and social development concerns warranting mitigation. Multifaceted sources were identified as contributing to children’s unhappiness, including restricted social interactions, educational challenges, emotional and psychological issues. Notably, children reported enhanced pre- to post-pandemic hygiene and sanitisation practices. Unsubstantiated beliefs relating to processes of recovery suggest the need for clearer communication in this regard. Conclusion: The study highlights the necessity for health education to support children in physical and psychological coping during a pandemic and build their resilience against future epidemics. Actively listening to children’s account of the SARS-CoV-2 coronavirus, and their pandemic experiences paves the way for making health education initiatives more relatable and attuned to their needs.
Fat-soluble vitamins as biomarkers of nutritional status and their relation with complications in polytrauma patients
Authors: Verheul Esmee AH , Horzum Ebru , Dijkink Suzan , Krijnen Pieta , Hoogendoorn Jochem M , Arbous Sesmu M , Peters Ron , Schipper Inger B 
Published: August 2024

Background and Aims This exploratory observational prospective study aimed to evaluate fat-soluble vitamin plasma levels during hospital admission and its relation with the development of malnutrition and complications in polytrauma patients, considering the protocolized multivitamin supplementation during intensive care unit (ICU) admission. Methods In 49 well-nourished polytrauma (injury severity score ≥ 16) patients admitted to the ICU of two level-1 trauma centers, vitamin A, D, and E levels were assessed weekly during hospital stay. All patients received multivitamin supplementation during ICU stay. Linear mixed-effect models were used to assess a trend in vitamin levels over time during hospital stay. Mixed-effects logistic regression analysis was performed to relate vitamin concentrations with malnutrition, defined as a subjective global assessment score ≤5, and complications. Results Vitamin A levels increased 0.17 µmol/L per week (95% confidence interval 0.12–0.22, p < 0.001), vitamin D levels increased 1.49 nmol/L per week (95% confidence interval 0.64–2.33, p < 0.01), vitamin E levels increased 1.17 µmol/L per week (95% confidence interval 0.61–1.73, p < 0.001) during hospital stay (29 ± 17 days). Vitamin levels were not related to malnutrition or complications during hospital stay. Conclusion Vitamin A, D, and E levels increased due to supplementation during hospital admission. Plasma levels of vitamins A, D, and E do not seem to be useful as biomarkers for the nutritional status of polytrauma patients during hospital stay. No correlation with complications could be demonstrated.
The consequences of spousal infidelity for long-term chronic health: A two-wave longitudinal analysis
Authors: Hoy Eunicia Q. W. , Oh Vincent Y. S. 
Published: August 2024

Objective: Research links low marital quality to poor mental and physical health, but the impact of spousal infidelity on long-term chronic health, especially using longitudinal data, is understudied. The present work investigates whether infidelity predicted long-term chronic health, and whether demographic factors and support or strain from friends or family moderated this relationship. Methods: Using longitudinal data from 2579 adults from the United States (1093 males, 1486 females; Mage = 57.17, Medianage = 56, SDage = 12.26, age range: 33–84 years), we examined associations between partner infidelity and chronic health conditions across two timepoints (T1: 2004–2006, T2: 2013–2014). We analyzed participants’ history of partner infidelity at T1 and its relationship with chronic health through mixed models as well as latent variable structural equation modelling. We also examined whether supportive relationships and demographic variables moderated these associations. Results: Controlling for demographic covariates (age, gender, education, ethnicity, employment, marital status, marital satisfaction and income level), infidelity was linked to poorer chronic health in mixed model analyses ( p < .001), and this finding was also supported in latent variable analyses that controlled for baseline chronic health ( p = .003). Additionally, moderation analyses found that the impact of infidelity on chronic health was larger among low-income individuals and ethnic minorities. Conclusion: Partner infidelity has lasting detrimental associations with chronic health that are not mitigated by positive relationships. The research highlights the potential long-term health implications of partner infidelity and suggests the need for interventions to mitigate such negative effects.
How do family carers assist people with dementia? A qualitative observation study of daily tasks
Authors: Camino Julieta , Trucco Ana Paula , Kishita Naoko , Mioshi Eneida , Backhouse Tamara 
Published: August 2024

Introduction: As people with dementia progressively experience difficulties when performing daily tasks, family carers often become the main providers of support. Little is known about the role of carer support during task performance. Therefore, Occupational Therapy interventions are often underinformed in this area. Knowledge of how carers assist people with dementia could support Occupational Therapists in promoting participation in daily tasks. The objective was to explore how carers support people with dementia during the performance of daily tasks. Methods: A secondary analysis was conducted on observations video-recorded for the TASKed project, where people with dementia completed a task with carer support. Data were analysed using an inductive reflexive thematic analysis approach. Findings: Video recordings of 21 dyads were included in this study. Five themes were generated depicting how carers supported people with dementia during task performance: (1) person-enabled assistance, (2) goal-directed assistance, (3) carer-led assistance, (4) partnership-oriented assistance and (5) bystander. Conclusion: Our findings suggest carers employ different approaches when assisting people with dementia with daily tasks. Knowledge of these different modes of assistance could help Occupational Therapists and researchers understand what works well and what could be changed to facilitate the participation of people with dementia in daily activities.
Biomass-derived epoxy resin and its application for high-performance natural fiber composites
Authors: Kumar Bijender , Adil Samia , Kim Jaehwan 
Published: August 2024

The development of bio-based materials with superior comprehensive properties from biomass resources remains a significant challenge, providing an alternative to conventional petroleum-based materials. This study explores the lignin-derived vanillyl alcohol epoxy (VAE) resin-containing mono and di (m&d) epoxy structure as an adhesive to develop environment-friendly natural fiber-reinforced composites to reduce the carbon footprint. The synthesized m&dVAE containing mono and di-epoxidized (m&d) aromatic rings, when cured with 4, 4´-diaminodiphenyl methane (DDM) hardener, exhibits higher record tensile strength ∼124.0 ± 8.43 MPa and tensile modulus ∼2.88 ± 0.35 GPa compared to a commercial petroleum-based epoxy, diglycidyl ether bisphenol A (DGEBA) thermoset. Additionally, it demonstrated higher adhesion shear strength (∼19.16 ± 0.58 MPa) with cellulose nanofibers film than DGEBA. Moreover, fabricated green composite possesses excellent flexural strength of ∼203.72 ± 2.08 MPa and stiffness of ∼11.58 ± 0.38 GPa than the petroleum-based thermoset composite. The composite’s fracture surface morphology shows that the resin and fibers have good interfacial adhesion. Notably, the sustainable composite showed good hydrophobicity and an excellent heat-resistant index of 144.4°C. The m&dVAE resin can be an alternative to petroleum-based resins as an adhesive, and its environment-friendly sustainable composite could be a promising candidate to replace synthetic materials for high-performance structural applications.
Inadequate anticoagulation and hyperuricemia cause knee pain after platelet-rich plasma injection: A retrospective study
Authors: Chen Yang , Sang Hongxun , Wu Song , Zhang Haobin , Zhang Yi , Li Hongxing 
Published: August 2024

Objectives Platelet-rich plasma treatment delays the need for total knee replacement in patients with knee osteoarthritis. However, its use and preparation remain controversial. The aim of this study was to investigate the relationship between anticoagulant use in the preparation of platelet-rich plasma and post-treatment pain in patients with knee osteoarthritis. Additionally, we explored the efficacy of platelet-rich plasma over medium- and long-term follow-up periods and identified other factors that may affect treatment outcomes. Methods In this retrospective study, 225 patients with knee osteoarthritis, who underwent knee platelet-rich plasma treatment from June 2021 to January 2022, were examined at three study centres. Patients were categorised, based on the type and amount of anticoagulant used during platelet-rich plasma preparation, into 4% sodium citrate (SC) 0.6 mL, 4% SC 1 mL, 4% SC 2 mL, heparin 0.1 mL, and heparin 0.2 mL groups. We analysed the patients’ basic information, pain after treatment, and inflammatory markers (i.e., interleukin 6, tumour necrosis factor-α, and hypersensitive C-reactive protein) in the joint fluid via enzyme-linked immunosorbent assay and joint fluid crystallisation. Additionally, we assessed the patients’ Western Ontario and McMaster University scores and minimal clinically significant differences after treatment. Results Patients in the 4% SC 0.6 mL and heparin 0.1 mL groups experienced less pain after platelet-rich plasma treatment than did patients in the high-dose anticoagulant group. The joint fluid of patients with pain in these groups had lower levels of inflammatory markers. Patients treated with SC had slightly better medium- and long-term therapeutic outcomes than did patients treated with heparin. Patients with poorly controlled hyperuricemia also experienced pain after platelet-rich plasma treatment. Conclusions The results suggest that platelet-rich plasma prepared using high-dose anticoagulants or administered to patients with poorly controlled hyperuricaemia may lead to moderate-to-severe knee pain and joint effusion after joint puncture therapy. Platelet-rich plasma had a therapeutic effect on knee osteoarthritis; however, its efficacy gradually decreased over time. SC anticoagulant is more suitable for platelet-rich plasma preparation than is heparin. Further studies are needed to understand the safety and the various factors influencing platelet-rich plasma therapy.
Joint Assortment and Price Optimization With Multiple Purchases
Authors: Luan Shujie , Wang Ruxian , Xu Xiaolin , Xue Weili 
Published: August 2024

In this article, we incorporate the effects of multi-unit purchases into consumer choice models and investigate the associated joint assortment and price optimization problems. Under the proposed two-stage choice framework, consumers first form a consideration set, and then select a product with the optimal quantity from the consideration set to maximize their utility. For the joint assortment and pricing problem with homogeneous consumers, we find that a multi-purchase-willingness-ordered assortment is optimal under certain technical conditions, and propose a polynomial-time algorithm to find the optimal assortment and prices for general cases. We further show that the optimal prices and assortment size are not monotone in multi-purchase preference and multi-purchase resistance. For the joint assortment and pricing problem with heterogeneous consumers, we first prove that this problem is NP-hard. We then consider a scenario with discrete prices and develop a fully polynomial-time approximation scheme by considering a finite number of consumer segments and nested consideration sets. We conduct an empirical study on the JD.com dataset and show that the new choice framework can improve model fitting and prediction accuracy compared with existing choice models with multiple purchases. We reveal that our model is especially suitable for datasets exhibiting a strong diminishing marginal effect for product variety. We further extend our analysis to price competition and establish the existence and uniqueness of a Nash equilibrium. For the joint optimization with fixed costs, we develop an algorithm that can find a solution guaranteeing at least half the optimal expected profit.
Activity of the Tobacco Industry in Research and Scientific Literature
Authors: Braun Markus , Klingelhöfer Doris , Brüggmann Dörthe , Groneberg David A. 
Published: August 2024

Introduction Tobacco companies conduct and fund research. They are not always interested in open-ended research. They promote their interests through public relations campaigns. It’s a proven fact that they influence the scientific community by impairing scientific reputation, especially in the case of health-related research. Methods To obtain a comprehensive picture of research and funding activities of the tobacco industry as well as studies about the tobacco industry, respective scientific articles were analyzed in terms of temporal aspects, research areas, networking, and funding sources using established and advanced bibliometric methods. Results We found the foci of publications with tobacco industry involvement or funding were mainly in chemistry, toxicology, pharmacology, and agricultural sciences. Health-related scopes occurred much less frequently. In contrast, health and medical sciences were the main focus of publications on the tobacco industry. The Chinese state-owned CNTC was the most research-involved tobacco company and often networked with Chinese academic institutions. Whereas, Western universities, on the other hand, collaborated with tobacco companies to a much lesser extent. Conclusion Conflicts of interest of researchers or academic institutions with the tobacco industry occur repeatedly. That is highly problematic and should not be ignored by the scientific community. The science and the public should be skeptical about tobacco industry-supported research.
‘Humans think outside the pixels’ – Radiologists’ perceptions of using artificial intelligence for breast cancer detection in mammography screening in a clinical setting
Authors: Johansson Jennifer Viberg , Engström Emma 
Published: August 2024

Objective This study aimed to explore radiologists’ views on using an artificial intelligence (AI) tool named ScreenTrustCAD with Philips equipment) as a diagnostic decision support tool in mammography screening during a clinical trial at Capio Sankt Göran Hospital, Sweden. Methods We conducted semi-structured interviews with seven breast imaging radiologists, evaluated using inductive thematic content analysis. Results We identified three main thematic categories: AI in society, reflecting views on AI’s contribution to the healthcare system; AI-human interactions, addressing the radiologists’ self-perceptions when using the AI and its potential challenges to their profession; and AI as a tool among others. The radiologists were generally positive towards AI, and they felt comfortable handling its sometimes-ambiguous outputs and erroneous evaluations. While they did not feel that it would undermine their profession, they preferred using it as a complementary reader rather than an independent one. Conclusion The results suggested that breast radiology could become a launch pad for AI in healthcare. We recommend that this exploratory work on subjective perceptions be complemented by quantitative assessments to generalize the findings.
Optical Coherence Tomography–Guided Stenting for Common Carotid Free-Floating Thrombus
Authors: Shen Guangxun , Zhao Jingmin , Mao Ying , Yu Xiao , Lee Kwee-Yum , Nan Guangxian 
Published: August 2024

A 57-year-old male with a history of esophagus cancer presented with acute dysarthria and mild weakness in his left extremities. Carotid duplex ultrasonography demonstrated a carotid free-floating thrombus (CFFT) in the right common carotid artery (CCA) extending to innominate artery (IA). It was difficult to determine the entity and the proximal end of the thrombus on digital subtraction angiography (DSA), but intravascular optical coherence tomography (OCT) showed unique morphological features and identified the exact location of the proximal and distal ends of the thrombus through the number of guide-wire artifacts, facilitating in making an informed decision regarding stent landing. After OCT-guided carotid artery stenting, DSA showed no residual free-floating thrombus and stenosis with complete recanalization in the CCA and IA. Our case highlights the rarity of a CFFT occurring in an uncommon location and OCT as a valuable adjunct to DSA in the management of CFFTs. Clinical Impact Digital subtraction angiography (DSA) has traditionally been considered an effective method for visualizing carotid free-floating thrombus (CFFT), but it falls short in providing detailed structures of the lumen and the composition of thrombi, making it challenging to determine the etiology. Intravascular optical coherence tomography (OCT) is a valuable adjunct to DSA that can precisely evaluate the characteristics of the intrinsic vessel wall and accurately distinguish between red and white thrombus, providing clues to the etiology of CFFTs. Moreover, OCT not only precisely determined the scope of a floating thrombus but also provided guidance for decision-making in endovascular treatment.
Jianpi Jiedu Recipe Inhibits Proliferation through Reactive Oxygen Species-Induced Incomplete Autophagy and Reduces PD-L1 Expression in Colon Cancer
Authors: Cheng Lingling , Xu Liangfeng , Yuan Hua , Zhao Qihao , Yue Wei , Ma Shuang , Wu Xiaojing , Gu Dandan , Sun Yurong , Shi Haifeng , Xu Jianlin 
Published: August 2024

Background: Jianpi Jiedu Recipe has been used to treat digestive tract tumors in China since ancient times, and its reliability has been proven by clinical research. Currently, the specific biological mechanism of JPJDR in treating tumors is unclear. Methodology: CCK-8 assay was used to detect cell viability. Clone formation assay and EdU assay were used to detect cell proliferation potential. DCFH-DA probe and JC-1 probe were used to detect total intracellular reactive oxygen species and mitochondrial membrane potential, respectively. Western blotting and immunofluorescence were used to detect protein expression level and subcellular localization of cells. The RFP-GFP-LC3B reporter system was used to observe the type of autophagy in cells. The xenograft tumor model was used to study the therapeutic effect of JPJDR in vivo. Results: JPJDR has an excellent inhibitory effect on various colorectal cancer cells and effectively reduces the proliferation ability of HT29 cells. After treatment with JPJDR, the amount of reactive oxygen species in HT29 cells increased significantly, and the mitochondrial membrane potential decreased. JPJDR induced the accumulation of autophagosomes in HT29 cells and was shown to be incomplete autophagy. At the same time, JPJDR reduced the expression of PD-L1. Meanwhile, JPJDR can exert an excellent therapeutic effect in xenograft tumor mice. Conclusion: JPJDR is a low-toxicity and effective anti-tumor agent that can effectively treat colon cancer in vitro and in vivo. Its mechanism may be inducing mitochondrial dysfunction and incomplete autophagy injury to inhibit the proliferation of colon cancer cells.
Redefining the exact roles and importance of carotid intima-media thickness and carotid plaque thickness in predicting cardiovascular events
Authors: Petrovic Dusan J. 
Published: August 2024

Objective The survey aimed to evaluate the precise roles and importance of carotid plaque thickness and carotid intima-media thickness measured in plaque-free areas (PF CC-IMTmean) in future cardiovascular risk prediction. Material and methods 188 respondents between the age of 46 and 87 divided into two groups (I group – 94 respondents without plaques with CIMT measurement and II Group 94 respondents with carotid plaques; 118 men and 70 women; mean age ± SD, 61.80 ± 5.49) were prospectively examined by the carotid ultrasound Doppler (carotid measurements included plaque thickness PT – nonstenotic plaques (carotid stenosis <50%) and stenotic culprit plaques (carotid stenosis ≥50%), mean CIMT and maximum CIMT). Subjects were followed for 36 months from the inclusion in the study (regular control examinations). Data were recorded on new cases of mortality (CV mortality) and adverse CV events (myocardial infarction – -MI, surgical or endovascular revascularization – coronary or stroke). Results In this study, CIMT values vary between 0.62 and 1.43 mm (mean CIMT = 1.21 ± 0.2 mm) while 52 subjects had nonstenotic plaques (14 respondents plaque ulceration, 22 type 2 diabetes mellitus, 38 arterial hypertension) and 38 subjects had stenotic culprit plaques (17 respondents plaque ulceration, 20 type 2 diabetes mellitus, 31 arterial hypertension). After 36 months of follow-up, 76 vascular events were noted (MI, transient ischaemic attack – TIA, stroke and cardiovascular angioplasty or surgery) in this period. Conclusion Respondents with carotid plaques had higher cardiovascular events occurrence ( p < .01, high statistical difference). Carotid plaques as a parameter have higher predictive vascular event value importance than CIMT. Of note, stenotic plaques, the presence of ulceration on the free surface of the plaque, type 2 diabetes mellitus and hypertension were connected with the highest events occurrence.