bluuebunny/crossref_metadata_2025_split huggingface dataset:
Endoplasmic Reticulum Stress of Neutrophils Is Required for Ischemia/Reperfusion–Induced Acute Lung Injury
Authors: Hu Rong , Chen Zhi-Feng , Yan Jia , Li Qi-Fang , Huang Yan , Xu Hui , Zhang Xiao-Ping , Jiang Hong 
Published: October 2015

Abstract
Diverse clinical factors, including intestinal ischemia, contribute to acute lung injury (ALI), which has up to a 40% mortality rate. During the development of lung injury an immune response is elicited that exacerbates the lung insult. Neutrophils have been well studied in mediating the pulmonary insults through an assortment of mechanisms, such as release of granule contents and production of proinflammatory cytokines due to the overactivation of complement and cytokines. In this study, we found that enhanced endoplasmic reticulum (ER) stress was observed in infiltrated neutrophils in the early stage of an ALI mice model. In neutrophils, complement 5a (C5a) inspires strong ER stress through inositol-requiring kinase 1a and, to a less extent, the protein kinase R–like ER kinase signaling pathway. The granule release induced by C5a was ER stress mediated. Knowkdown of X-box–binding protein 1, a downstream signaling molecule of inositol-requiring kinase 1a, impaired granule release, based on myeloperoxidase production. Further analysis revealed that C5a induced ER stress by binding to C5a receptor in neutrophils. Using xbpf/f MRP8-cre mice in which X-box–binding protein 1 is deficient specifically in neutrophils and ER stress is deprived, we confirmed that ER stress in neutrophils was required for granule release in vivo and led to ALI, whereas dampening ER stress in neutrophils substantially alleviated ALI. Taken together, our results demonstrated that C5a receptor–mediated ER stress induced granule release in neutrophils, contributing to the development of ALI. This novel mechanism suggests a new potential therapeutic target in autophagy regulation for ALI.
A Central Role for HLA-DR3 in Anti-Smith Antibody Responses and Glomerulonephritis in a Transgenic Mouse Model of Spontaneous Lupus
Authors: Chowdhary Vaidehi R. , Dai Chao , Tilahun Ashenafi Y. , Hanson Julie A. , Smart Michele K. , Grande Joseph P. , Rajagopalan Govindarajan , Fu Shu-Man , David Chella S. 
Published: October 2015

AbstractMHC, especially HLA-DR3 and HLA-DR2, is one of the most important genetic susceptibility regions for systemic lupus erythematosus. Human studies to understand the role of specific HLA alleles in disease pathogenesis have been hampered by the presence of strong linkage disequilibrium in this region. To overcome this, we produced transgenic mice expressing HLA-DR3 (DRβ1*0301) and devoid of endogenous class II (both I-A and I-E genes, AE0) on a lupus-prone NZM2328 background (NZM2328.DR3+AE0). Both NZM2328 and NZM2328.DR3+AE0 mice developed anti-dsDNA and glomerulonephritis, but anti-dsDNA titers were higher in the latter. Although kidney histological scores were similar in NZM2328 and NZM2328.DR3+AE0 mice (7.2 ± 4.3 and 8.6 ± 5.7, respectively, p = 0.48), the onset of severe proteinuria occurred earlier in NZM2328.DR3+AE0 mice compared with NZM2328 mice (median, 5 and 9 mo respectively, p &lt; 0.001). Periarterial lymphoid aggregates, classic wire loop lesions, and occasional crescents were seen only in kidneys from NZM2328.DR3+AE0 mice. Interestingly, NZM2328.DR3+AE0 mice, but not NZM2328 mice, spontaneously developed anti-Smith (Sm) Abs. The anti-Sm Abs were seen in NZM2328.DR3+AE0 mice that were completely devoid of endogenous class II (AE-/-) but not in mice homozygous (AE+/+) or heterozygous (AE+/−) for endogenous MHC class II. It appears that only HLA-DR3 molecules can preferentially select SmD-reactive CD4+ T cells for generation of the spontaneous anti-Sm immune response. Thus, our mouse model unravels a critical role for HLA-DR3 in generating an autoimmune response to SmD and lupus nephritis in the NZM2328 background.
Cohabitation in the Intestine: Interactions among Helminth Parasites, Bacterial Microbiota, and Host Immunity
Authors: Reynolds Lisa A. , Finlay B. Brett , Maizels Rick M. 
Published: October 2015

Abstract
Both intestinal helminth parasites and certain bacterial microbiota species have been credited with strong immunomodulatory effects. Recent studies reported that the presence of helminth infection alters the composition of the bacterial intestinal microbiota and, conversely, that the presence and composition of the bacterial microbiota affect helminth colonization and persistence within mammalian hosts. This article reviews recent findings on these reciprocal relationships, in both human populations and mouse models, at the level of potential mechanistic pathways and the implications these bear for immunomodulatory effects on allergic and autoimmune disorders. Understanding the multidirectional complex interactions among intestinal microbes, helminth parasites, and the host immune system allows for a more holistic approach when using probiotics, prebiotics, synbiotics, antibiotics, and anthelmintics, as well as when designing treatments for autoimmune and allergic conditions.
Need for Cognition and False Memory: Can One’s Natural Processing Style Be Manipulated by External Factors?
Authors: Wootan Samantha S. , Leding Juliana K. 
Published: October 2015

Abstract
The purpose of this experiment was to provide an enhanced understanding of need for cognition (NFC) and its influence on one’s memory accuracy. People who are high in NFC tend to put more cognitive effort into their mental processes than their low-NFC counterparts. To determine whether one’s natural processing tendencies, as determined by NFC, can be influenced by external factors, manipulations to levels of processing were added. Participants viewed word lists from the Deese–Roediger–McDermott (DRM) paradigm and were instructed to process half of the DRM lists deeply and the other half shallowly. After all the lists were presented, participants completed 3 successive recall tests. The deep processing condition produced higher rates of false memories for both NFC groups than the shallow processing condition. In addition, the high-NFC group produced higher rates of target recall in both the deep and shallow conditions than the low-NFC group. However, the high-NFC group also produced higher rates of false recall for the shallowly processed lists. These data indicate that high-NFC people exhibit enhanced target recall for word lists, which may come at the expense of overall accuracy due to the increase of false recall.
Do Psychological Sex Differences Reflect Evolutionary Bisexual Partitioning?
Authors: Trofimova Irina 
Published: October 2015

Abstract
This article analyzes sex differences in communicative and exploratory abilities and mental disabilities from the rarely discussed perspective of sex differences in the shape of phenotypic distributions. The article reviews the most consistent findings related to such differences and compares them with the evolutionary theory of sex (ETS). The ETS considers sexual dimorphism as a functional specialization of a species into 2 partitions: variational and conservational. The analysis suggests that male superiority in risk and sensation seeking and physical abilities; higher rates of psychopathy, dyslexia, and autism; and higher birth and accidental death rates reflects the systemic variational function of the male sex. Female superiority in verbal abilities, lawfulness, socialization, empathy, and agreeableness is presented as a reflection of the systemic conservational function of the female sex. From this perspective psychological sex differences in communicative and exploratory abilities might not just be an accidental result of sexual selection or labor distribution in early humans. It might reflect a global functional differentiation tendency within a species to expand its phenotypic diversity and at the same time to conserve beneficial features in the species’ behavior. The article also offers an addition to the ETS by suggesting that the male sex (variable partition) plays an evolutionary role in pruning of the redundant excesses in a species’ bank of beneficial characteristics despite resistance from the conservational partition.
Cognitive Trajectories in Older Adults Diagnosed With Hematologic Malignant Neoplasms
Authors: Huang Li-Wen , Shi Ying , Boscardin W. John , Steinman Michael A. 
Published: August 2024

ImportanceMore people are surviving long-term after diagnosis with hematologic malignant neoplasm (HMN), yet there are limited data on cancer-related cognitive impairment in people with HMN. Better understanding cognitive outcomes after HMN in older adults is important for patient counseling and management.ObjectiveTo model cognitive trajectories and rates of cognitive decline before and after HMN diagnosis in older adults compared with a matched noncancer cohort.Design, Setting, and ParticipantsIn this population-based cohort study, older adults from the Health and Retirement Study (HRS) diagnosed with HMN between 1998 and 2016 after age 65 years were matched 1:3 to participants without cancer from the same HRS wave using propensity scores incorporating variables relevant to cognition. Cognitive trajectories were modeled with piecewise linear splines, and rates of cognitive decline before, during, and after diagnosis were compared in the 2 groups. Data were analyzed from April 2022 to April 2024.ExposuresHMN diagnosis by Medicare diagnosis codes.Main Outcomes and MeasuresCognitive function was assessed by the Langa-Weir cognitive summary score from 1992 to 2020. Sociodemographic and health-related variables relevant to cognition were incorporated into propensity scores.ResultsAt baseline, there were 668 participants in the HMN cohort (mean [SD] age, 76.8 [7.6] years; 343 [51.3%] male; 72 [10.8%] Black, 33 [4.9%] Hispanic, and 585 [87.6%] White) and 1994 participants in the control cohort (mean [SD] age, 76.5 [7.3] years; 1020 [51.2%] male; 226 [11.3%] Black, 91 [4.6%] Hispanic, and 1726 [86.6%] White). The HMN cohort consisted predominantly of more indolent diagnoses, and only 96 patients (14.4%) received chemotherapy. Before and in the 2 years around the time of diagnosis, the HMN and control cohorts had similar rates of cognitive decline. At 1 year postdiagnosis and beyond, the rate of cognitive decline was slower in the HMN cohort (−0.18; 95% CI, −0.23 to –0.14) than in the control group (−0.24; 95% CI, −0.26 to –0.23) (P = .02), but this difference was no longer significant after accounting for the competing risk of death (HMN group, −0.27; 95% CI, −0.34 to –0.19; control group, −0.30; 95% CI, −0.33 to –0.27; P = .48).Conclusions and RelevanceIn this cohort study of older adults, the HMN and matched noncancer control cohorts had similar rates of cognitive decline before, during, and after diagnosis after accounting for the competing risk of death.
Hydroxychloroquine and Cardiovascular Events in Patients With Systemic Lupus Erythematosus
Authors: Grimaldi Lamiae , Duchemin Tom , Hamon Yann , Buchard Albert , Benichou Jacques , Abenhaim Lucien , Costedoat-Chalumeau Nathalie , Moride Yola 
Published: August 2024

ImportanceSystemic lupus erythematosus (SLE) predisposes individuals to early cardiovascular (CV) events. While hydroxychloroquine is thought to mitigate CV risk factors, its protective role against CV events, particularly arterial ones, remains to be confirmed.ObjectiveTo evaluate the association between hydroxychloroquine and the risk of myocardial infarction (MI), stroke, and other thromboembolic events (OTEs) in patients with SLE.Design, Setting, and ParticipantsThis cohort study using a nested case-control design was conducted within the National French Healthcare Database (SNDS), which represents 99% of the French population, from 2010 to 2020. Participants were the cohort of all patients with SLE recorded in the SNDS. Patients with SLE experiencing CV events during the study period were the case group; those without CV events were controls. The analysis period was from February 2022 to September 2023.ExposuresHydroxychloroquine use within 365 days prior to the index date, defined as current (within 90 days), remote (91-365 days), or no exposure within the previous 365 days.Main Outcomes and MeasuresOutcomes of interest were MI, stroke, and OTE, analyzed individually and as a composite outcome (primary analysis). Controls were matched to patients with CV events by age, sex, time since SLE onset and entry into the SNDS database, index date, prior antithrombotic and CV medication, chronic kidney disease, and hospitalization. Multivariable conditional logistic regression was performed using hydroxychloroquine exposure as the main independent variable.ResultsThe SLE cohort included 52 883 patients (mean [SD] age, 44.23 [16.09] years; 45 255 [86.6%] female; mean [SD] follow-up, 9.01 [2.51] years), including 1981 patients with eligible CV events and 16 892 matched control patients. There were 669 MI events, 916 stroke events, and 696 OTEs in the individual outcome studies. For current exposure to hydroxychloroquine, the adjusted odds were lower for composite CV events (odds ratio [OR], 0.63; 95% CI, 0.57-0.69) as well as for MI (OR, 0.72; 95% CI, 0.60-0.85), stroke (OR, 0.69; 95% CI, 0.60-0.81), and OTEs (OR, 0.58; 95% CI, 0.49-0.69) individually compared with no hydroxychloroquine exposure within 365 days.Conclusions and RelevanceIn this nationwide cohort study of patients with SLE, a protective association was found between the current use of hydroxychloroquine and the occurrence of CV events, but not between remote use of hydroxychloroquine and CV outcomes, highlighting the value of continuous hydroxychloroquine treatment in patients with SLE.
Emerging Active Materials for Solar Cells: Progress and Prospects
Authors: Tran Vy Anh , Le Van Thuan , Phan Thi Thu Trinh , Trinh Minh Tuan 
Published: August 2024

AbstractSolar energy has become increasingly important in today's world as a clean and abundant energy source. Its significance spans across environmental, economic, and technological dimensions, making it a cornerstone for the future of energy production. However, widespread adoption of solar energy is hindered by the high costs associated with large‐scale implementation. To facilitate a broad transition to renewable energy, it is essential to actively explore various emerging materials for highly efficient and cost‐effective solar cells. With the recent advances in materials science, numerous emerging materials show high potential for these purposes. For example, rapid progress in perovskite research highlights its potential for making low‐cost and highly efficient solar cells. This review presents a comprehensive overview of emerging active materials for solar cells, covering fundamental concepts, progress, and recent advancements. The key breakthroughs, challenges, and prospects will be highlighted with a focus on solar cells based on organic materials, perovskite materials, and colloidal quantum dots. By delving into the progress and obstacles associated with these materials, this review offers valuable insights into the development of solar cell technology. As it is continued to unlock the potential of solar energy, this abundant and environmentally friendly energy source becomes increasingly viable.
Recursive set‐membership filtering for two‐dimensional shift‐varying systems with FlexRay protocol and hybrid cyber attacks
Authors: Zhang Pan , Zhu Chaoqun , Wang Zhiwen , Yang Bin 
Published: August 2024

AbstractThe problem of recursive set‐membership filter design for two‐dimensional (2‐D) systems subject to FlexRay communication protocol and hybrid cyber attacks (HCAs) is investigated in this article. The FlexRay protocol that integrates time‐triggered and event‐triggered mechanisms and involves a series of pre‐defined communication cycles based on bidirectional metrics is developed to alleviate the network bandwidth load. Furthermore, the envisioned system is exposed to false data injection and denial‐of‐service attacks that occur in a randomized manner. Subsequently, the dynamic filtering error system (FES) subject to bidirectional evolutionary HCAs and FlexRay scheduling protocol is constructed. Then, sufficient conditions are obtained such that the dynamic FES consistently resides within an ellipsoidal set by utilizing double mathematical induction and recursive linear matrix inequalities (RLMIs). Moreover, the optimal filtering algorithm is given by minimizing the ellipsoidal constraints from the perspective of the traces of the matrix. The effectiveness of the presented recursive set‐membership filter design approach is validated by a long‐distance transmission line example.
Boosting the Oxygen Evolution Reaction Performance of Ni‐Fe‐Electrodes by Tailored Conditioning
Authors: Gohlke Clara , Gallenberger Julia , Niederprüm Nico , Ingendae Hannah , Kautz Johann , Hofmann Jan P. , Mechler Anna K. 
Published: August 2024

AbstractTo meet the rising demand for green hydrogen, efficient alkaline water electrolysis demands highly active and low‐cost electrocatalysts for the oxygen evolution reaction (OER). We address this issue by focusing our work on optimizing the conditioning of promising Ni‐(Fe)‐based electrodes to improve their electrocatalytic performances. Systematic parameter variation for cyclic voltammetry conditioning revealed that a large potential window, low scan rate, and a high number of cycles result in improved activation. If the conditioning time is fixed, a high scan rate was found beneficial. A remarkable 47±6 mV potential drop at 10 mA cm−2 was achieved for Ni70Fe30 when conditioning between −0.35–1.6 V at 100 mV s−1 for just 30 min. We could demonstrate that this activation persisted over 100 h at 100 mA cm−2, underscoring its enduring efficacy. We suggest that this activation effect results from the growth of a hydrous hydroxide layer, which is supported by energy dispersive X‐ray spectroscopy and X‐ray photoelectron spectroscopy. Fe incorporation or dissolution played only a minor role in the differences in electrode activation, as demonstrated by variation of the Fe content in the electrolyte. Our work stresses the importance of conditioning in enhancing OER performance and explores how to improve the catalysts′ effectiveness by tailoring oxides.
International mergers and acquisitions and institutional differences: An integrated approach
Authors: Cieślik Andrzej , Tarsalewska Monika 
Published: August 2024

AbstractIn this paper we study the role of institutional differences in bilateral mergers and acquisitions (M&As) in an integrated framework. We contribute to the literature on the drivers of international M&As by integrating the gravity, knowledge‐capital (KK) and political economy theory (PET) approaches and explain cross‐border M&As using an international and comprehensive dataset. We estimate the model using Poisson Pseudo Maximum Likelihood (PPML) method with high dimension fixed effects. The main findings are that the variables that affect cross‐border M&As can be derived from three different approaches explaining activity of multinational enterprises (MNEs): the gravity equation, the KK model, and the PET frameworks. In particular, variables related to geographical proximity, size and similarity of markets and differences in regulatory quality are important in explaining M&A activity.
Islamic mutual funds: Seasonal patterns and determinants of performance across regions
Authors: Labidi Chiraz , Arreola Hernandez Jose , Uddin Gazi Salah , Ahmed Ali , Yahya Muhammad , Yoon Seong‐Min 
Published: August 2024

AbstractOur study aims to investigate the seasonal patterns of returns and evaluate the effects that various factors have on the performance in a large data set (125 funds) of Islamic mutual funds from four regions: Asia‐Pacific, North America, Europe, and the Middle East and North Africa (MENA). We employed indicators for consumer sentiment, economic policy uncertainty, implied stock market volatility, the trade‐weighted US dollar, the Carhart (1997) risk factors, and idiosyncratic risk. Our findings indicate that the seasonal patterns and determinants of Islamic mutual funds' financial performance tend to differ significantly across the regions. This may be explained by the different cultural/religious settings, the different backgrounds of the market participants as well as differences in the holiday seasons and end of fiscal year/taxation across regions/countries. Global fund managers and investors may benefit from the obtained results when constructing portfolios and designing hedging strategies.
B10 cells regulate macrophage polarization to alleviate inflammation and bone loss in periodontitis
Authors: Cao Guoqin , Xu Qiuping , Huang Shengyuan , Dai Dong , Wang Jilei , Li Wei , Zhao Yue , Lin Jiang , Han Xiaozhe 
Published: August 2024

AbstractBackgroundThe polarization of macrophages into an anti‐inflammatory phenotype is crucial for resolving periodontal inflammation. It has been reported that B10 cells can regulate the immune response of macrophages during inflammation and are also able to regulate inflammation in periodontitis. However, whether B10 cells’ regulation function in periodontitis is related to macrophage polarization remains unclear. This study aims to investigate whether B10 cells can regulate macrophage polarization in periodontitis.MethodsMacrophages were cocultured with B10 cells in vitro for 5 days. After coculture, macrophages were obtained for analysis directly or followed by stimulation with Pg‐LPS/IFN‐γ or IL‐4/IL‐13. Flow cytometry and/or reverse transcriptase‐polymerase chain reaction (RT‐PCR) were employed to detect the expression of IL‐1β, iNOS, TNF‐α, CD206, and ARG‐1 in macrophages. B10 cells were transferred on the 5th day after ligation in wild or macrophage‐depletion mice. Toluidine blue and TRAP staining were used to evaluate alveolar bone resorption and osteoclast activation. Immunohistochemistry was employed to detect the expression of CD68, IL‐1β, TNF‐α, iNOS, ARG‐1, and IL‐10. Immunofluorescence was used to detect the expression of CD68+CD86+M1 macrophages and CD68+CD206+M2 macrophages.ResultsIn vitro, B10 cells inhibit the expression of IL‐1β, iNOS, and TNF‐α in macrophages while increasing the expression of CD206 and ARG‐1. In experimental periodontitis, B10 cells inhibit the polarization of CD68+CD86+M1 macrophages and iNOS expression but enhance the polarization of CD68+CD206+M2 macrophages and ARG‐1 expression. Importantly, the depletion of macrophages partially weakened the regulation function of B10 cells in periodontitis.ConclusionsB10 cells promote M2 macrophage polarization, inhibit M1 macrophage polarization in periodontitis, and alleviate periodontitis partially by regulating macrophage polarization.
Nachruf: Dieter Ziessow (1940 – 2024)
Authors: Blümich Bernhard , Fels Gregor , Gasteiger Johann , Kast Stefan , Sielaff Marco , Steinbeck Christoph , Wille Eva E. 
Published: August 2024

AbstractDieter Ziessows Leitmotiv war die Kombination von Chemie/ Spektroskopie, Computer und Lehre.