bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacological mechanisms of Ma Xing Shi Gan Decoction in treating influenza virus-induced pneumonia: intestinal microbiota and pulmonary glycolysis
Authors: Jiang Lin , Bai Chen , Zhu Jingru , Su Chen , Wang Yang , Liu Hui , Li Qianqian , Qin Xueying , Gu Xiaohong , Liu Tiegang 
Published: August 2024

BackgroundInfluenza virus is one of the most common pathogens that cause viral pneumonia. During pneumonia, host immune inflammation regulation involves microbiota in the intestine and glycolysis in the lung tissues. In the clinical guidelines for pneumonia treatment in China, Ma Xing Shi Gan Decoction (MXSG) is a commonly prescribed traditional Chinese medicine formulation with significant efficacy, however, it remains unclear whether its specific mechanism of action is related to the regulation of intestinal microbiota structure and lung tissue glycolysis.ObjectiveThis study aimed to investigate the mechanism of action of MXSG in an animal model of influenza virus-induced pneumonia. Specifically, we aimed to elucidate how MXSG modulates intestinal microbiota structure and lung tissue glycolysis to exert its therapeutic effects on pneumonia.MethodsWe established a mouse model of influenza virus-induced pneumoni, and treated with MXSG. We observed changes in inflammatory cytokine levels and conducted 16S rRNA gene sequencing to assess the intestinal microbiota structure and function. Additionally, targeted metabolomics was performed to analyze lung tissue glycolytic metabolites, and Western blot and enzyme-linked immunosorbent assays were performed to assess glycolysis-related enzymes, lipopolysaccharides (LPSs), HIF-1a, and macrophage surface markers. Correlation analysis was conducted between the LPS and omics results to elucidate the relationship between intestinal microbiota and lung tissue glycolysis in pneumonia animals under the intervention of Ma Xing Shi Gan Decoction.ResultsMXSG reduced the abundance of Gram-negative bacteria in the intestines, such as Proteobacteria and Helicobacter, leading to reduced LPS content in the serum and lungs. This intervention also suppressed HIF-1a activity and lung tissue glycolysis metabolism, decreased the number of M1-type macrophages, and increased the number of M2-type macrophages, effectively alleviating lung damage caused by influenza virus-induced pneumonia.ConclusionMXSG can alleviate glycolysis in lung tissue, suppress M1-type macrophage activation, promote M2-type macrophage activation, and mitigate inflammation in lung tissue. This therapeutic effect appears to be mediated by modulating gut microbiota and reducing endogenous LPS production in the intestines. This study demonstrates the therapeutic effects of MXSG on pneumonia and explores its potential mechanism, thus providing data support for the use of traditional Chinese medicine in the treatment of respiratory infectious diseases.
Unveiling the multifaceted roles of microRNAs in extracellular vesicles derived from mesenchymal stem cells: implications in tumor progression and therapeutic interventions
Authors: Hu Sujia , Zhang Chang , Ma Qianhui , Li Minghe , Yu Xiao , Zhang Haiying , Lv Shuang , Shi Yingai , He Xu 
Published: August 2024

Graphical AbstractThe multifaceted roles of EV-miRNAs derived from MSCs in tumor progression and therapeutic applications. MSC-EVs can transfer miRNAs into tumor cells to regulate cell proliferation, invasion and metastasis, immune response, angiogenesis, and chemosensitivity as well. One or more of MSCs, EVs and miRNAs can be modified to achieve the inhibitory effect on tumor progression, which provides the promising approaches for tumor clinical treatment. Besides, miRNAs in EVs can also mediate the interaction between MSCs and tumor cells in the TME (Created with Biorender.com).
Celastrus orbiculatus Thunb. extracts and celastrol alleviate NAFLD by preserving mitochondrial function through activating the FGF21/AMPK/PGC-1α pathway
Authors: Xue Junli , Liu Yunchao , Liu Boyan , Jia Xiubin , Fang Xinsheng , Qin Shucun , Zhang Ying 
Published: August 2024

ObjectiveNon-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disease globally, characterized by the accumulation of lipids, oxidative stress, and mitochondrial dysfunction in the liver. Celastrus orbiculatus Thunb. (COT) and its active compound celastrol (CEL) have demonstrated antioxidant and anti-inflammatory properties. Our prior research has shown the beneficial effects of COT in mitigating NAFLD induced by a high-fat diet (HFD) in guinea pigs by reducing hepatic lipid levels and inhibiting oxidative stress. This study further assessed the effects of COT on NAFLD and explored its underlying mitochondria-related mechanisms.MethodsCOT extract or CEL was administered as an intervention in C57BL/6J mice fed a HFD or in HepG2 cells treated with sodium oleate. Oral glucose tolerance test, biochemical parameters including liver enzymes, blood lipid, and pro-inflammatory factors, and steatosis were evaluated. Meanwhile, mitochondrial ultrastructure and indicators related to oxidative stress were tested. Furthermore, regulators of mitochondrial function were measured using RT-qPCR and Western blot.ResultsThe findings demonstrated significant reductions in hepatic steatosis, oxidative stress, and inflammation associated with NAFLD in both experimental models following treatment with COT extract or CEL. Additionally, improvements were observed in mitochondrial structure, ATP content, and ATPase activity. This improvement can be attributed to the significant upregulation of mRNA and protein expression levels of key regulators including FGF21, AMPK, PGC-1α, PPARγ, and SIRT3.ConclusionThese findings suggest that COT may enhance mitochondrial function by activating the FGF21/AMPK/PGC-1α signaling pathway to mitigate NAFLD, which indicated that COT has the potential to target mitochondria and serve as a novel therapeutic option for NAFLD.
Preliminary evaluation of a novel method for computed tomography quantification of lumbosacral articular process displacement in dogs with and without degenerative lumbosacral stenosis
Authors: Carballo Oscar , Frederick Steven W. , Keys Deborah A. , Moore Sarah A. , Giles James T. 
Published: August 2024

ObjectiveThis study aimed to describe the diagnostic discrimination and reliability of a novel technique for quantifying lumbosacral articular process displacement (LSAPD) on dorsal plane computed tomography (DPCT) imaging in dogs with and without degenerative lumbosacral stenosis (DLSS).Study designDPCT surveys of the lumbosacral vertebral column were performed with dogs positioned in extension and flexion. LSAPD is defined as the distance between the cranial aspects of the L7 and S1 articular processes. The LSAPD ratio is identified by dividing the LSAPD by the length of the L7 articular process. Intraclass correlation coefficients (ICCs) for intra- and inter-observer reliability were calculated, and logistic regressions were used to test for the association of LSAPD and LSAPD ratio with odds of DLSS. Significance was set at 0.05. Receiver operator characteristic (ROC) curves were calculated to determine diagnostic discrimination and optimal cutoff for LSAPD and LSAPD ratio in the diagnosis of DLSS.ResultsIntra- and inter-observer reliabilities were excellent for most measurements. In the current cohort, excluding covariates, the area under the curve (AUC) (95%CI) for LSAPD and LSAPD ratio measured in a flexed position were both 0.89 (0.82–0.96), suggesting potentially excellent discrimination for using this measurement as a marker for diagnosing DLSS, pending further studies. The cutoffs for flexed LSAPD and LSAPD ratio that maximizes Youden’s index were ≥ 1.2 mm and ≥ 9%, respectively. When age and weight were subsequently included as covariates in a multivariable analysis, a significant relationship between LSAPD or LSAPD ratio and odds of diagnosis of DLSS was not demonstrated, suggesting the need for a larger sample size.ConclusionThe results of this study suggest that measurements of LSAPD and LSAPD ratio on DPCT are feasible and reliable, although their diagnostic discrimination in DLSS should be evaluated further in future prospective studies.
Aprendendo química no período remoto
Authors: Yamaguchi Klenicy Kazumy de Lima , Rodrigues Cristiana Nunes 
Published: August 2024

RESUMO
Existem muitas aplicações dos conceitos químicos no cotidiano. No entanto, nem sempre os discentes conseguem fazer essa associação. O objetivo deste projeto de extensão é apresentar a aplicação de química utilizando ferramentas tecnológicas didáticas como forma de contribuição para a popularização dos conhecimentos científicos. Como metodologia, foram elaborados vídeos de curta duração, folders e publicações apresentando os conceitos químicos aplicados ao cotidiano. Os materiais elaborados foram publicitados nas redes sociais que foram criadas para o projeto e que tiveram interação com os estudantes do ensino básico e superior, além de professores e da comunidade. O projeto contribuiu para a aprendizagem de conceitos químicos de forma simples e aplicada, promovendo, assim, aquisição de conhecimento para a comunidade, com associação da teoria com a prática e motivação para formação de cidadãos críticos e reflexivos.
ANÁLISE TEMPORAL DE CASOS DE AVC E INFARTO NO BRASIL: TENDÊNCIAS E FATORES ASSOCIADOS ( 2018-2023)
Authors: Reis Lima Andressa Bianca , Carvalho Clara Vitória Cavalcante , Pontes Roberta Ferreira , Spido Maria Victoria , Castro Carla Cilene Nascimento , De Melo Wellington Rodrigo Gomes , Cantanhede Ana Luísa Duarte , Cantanhede João Arthur Duarte , Costa Rita de Cássia Gomes , Véras Saul Felipe Oliveira , De Almeida Iasmin Dutra , Muzzy Leonardo Alves , Da Silva Júlia Martins , Da Silva Renata Barreto , Leite Fabrícia Vieira , Queiroz Ana Beatriz de Oliveira , Mota Samantha Maria Barbosa , da Rocha Carina Pereira 
Published: August 2024

O Acidente Vascular Cerebral (AVC) e o Infarto Agudo do Miocárdio (IAM) são duas das principais causas de morbidade e mortalidade no mundo. Ambos resultam de problemas na circulação sanguínea, com o AVC afetando o cérebro e o IAM impactando o coração. O presente trabalho tem o objetivo de fazer uma análise temporal acerca do panorama clínico e epidemiológico das internações por Infarto Agudo do Miocárdio e Acidente Vascular Encefálico no Brasil .Trata-se de um estudo descritivo, quantitativo e retrospectivo,com base em dados obtidos através do Sistema de Morbidade Hospitalar (SIH), no Departamento de Informática do Sistema Único de Saúde (DATASUS). O total de casos confirmados de internação por IAM ou AVC, no Brasil, entre 2018 e 2023, foi de 1.995.486 . O sudeste do país foi a região que apresentou maiores números de casos (n=898.358).A faixa etária com maior frequência de casos de IAM e AVC foi a de 60 a 69 anos, correspondendo a um percentual de 27,80% (n=554.819) dos casos. Os indivíduos, em sua maioria, apresentavam a cor/ raça parda correspondendo a 38,83% (n=774.936) dos casos, seguido dos indivíduos autodeclarados brancos com percentual de 36,94% (n=737.310). A amostra , em sua maioria,foi composta por indivíduos do sexo masculino 57,23% (n=1.142.050). A maioria dos pacientes deu entrada no hospital em caráter de urgência correspondendo a um total de 93,95%. A média de internação dos pacientes foi de 7,1 dias. Houveram 244.742 óbitos durante o período analisado, dos quais 28% eram pacientes entre 70 a 79 anos de idade. No estudo, ficou evidente o padrão de crescimento do número de casos e um aumento da incidência em pessoas mais jovens, embora não haja muitos estudos na área que possam explicar esse fenômeno.
Osadzony o odmiennej tożsamości płciowej w perspektywie więziennej
Authors: Zając Bartosz 
Published: August 2024

W artykule poruszono problematykę odmiennej tożsamości płciowej skazanych mężczyzn odbywających karę pozbawienia wolności w polskim systemie penitencjarnym. Badano opinię funkcjonariuszy Służby Więziennej na temat uregulowań prawnych, proponowanych rozwiązań czy potencjalnych zagrożeń dotyczących ich osadzenia. W szczególności sprawdzano, czy umieszczenie takich osób nie narusza ich podstawowych praw dotyczących poszanowania godności.
The article talks about different of transgender males in Polish penitentiary system. Opinion survey was checked on prison service, about transgender males, legal regulations, proposed solutions in this topic or potential hazards for this type of inmates. In particular, checked whether their rights and dignity have not been violated.
Microbiological Landscape of Intensive Care Unit: A Retrospective Analysis of Bacterial Pathogens and Their Implications
Authors: Sukmantara I Putu Bayu , Dewa Ayu Putu Diah Dharmayanti  , Dewa Ngakan Gde Dwija Sanjaya  
Published: August 2024

Introduction: The intensive care unit (ICU) is a high-risk environment for hospital-acquired infections (HAIs) due to the complex interplay of patient vulnerability, invasive procedures, and the selective pressure of antimicrobial use. Understanding the local epidemiology of bacterial pathogens is crucial for effective infection prevention and control strategies. This study aimed to characterize the bacterial profile in an ICU setting, providing insights into the prevalent pathogens and their potential implications for patient care.
Methods: A retrospective cross-sectional study was conducted, encompassing patients admitted to the ICU of Bangli Hospital Bali in 2023 and 2024. Data on patient demographics, sample sources, and microbiological findings were collected from medical records. Samples included blood cultures, sputum cultures (from both endotracheal tubes and spontaneous expectoration), wound swabs, and other sterile site cultures. Microbiological identification was performed using standard laboratory techniques.
Results: A total of 219 patients were included in the study. The most common sample source was blood culture (42.9%), followed by sputum culture from endotracheal tubes (39.3%). A significant proportion of cultures showed no growth (34.7%), highlighting the challenges in identifying causative pathogens in the ICU. Among the identified pathogens, Staphylococcus spp. was predominant (15.5%), followed by Stenotrophomonas maltophilia (9.6%) and coagulase-negative staphylococci (8.7%). The distribution of pathogens varied across sample sources, with Staphylococcus spp. being prevalent in sputum cultures from endotracheal tubes and Klebsiella pneumoniae in sputum cultures.
Conclusion: This study underscores the dynamic nature of the microbiological landscape in the ICU. The predominance of Staphylococcus spp., Stenotrophomonas maltophilia, and other opportunistic pathogens emphasizes the need for robust infection prevention and control measures. Further research is warranted to explore the impact of these pathogens on patient outcomes and to optimize antimicrobial stewardship in this critical care setting.
Pengaruh Shopping Lifestyle, Promosi, dan Store Atmosphere Terhadap Impulse Buying KKV Store Tunjungan Plaza Surabaya
Authors: Sekarrini Elizabeth Kharisma Ajeng , T Citra Anggraini 
Published: August 2024

Keberadaan bisnis ritel saat ini mengalami pertumbuhan yang sangat pesat dan salah satu bisnis ritel yang ada adalah KKV Store. KKV Store dituntut untuk terus melakukan strategi serta mempertahankan keinginan serta kebutuhan dari para konsumen sehingga konsumen akan tertarik untuk melakukan pembelian walaupun tidak direncanakan sebelumnya. Penelitian ini memiliki untuk melihat apakah shopping lifestyle, promosi, dan store atmosphere berpengaruh terhadap impulse buying KKV Store Tunjungan Plaza Surabaya. Penelitian dilakukan secara secara kuantitatif dan pengumpulan data menggunakan kuesioner. Sebanyaka 75 responden menjadi sampel pada penelitian ini dengan teknik purposive sampling. Alat statistik penelitian ini yaitu SPSS versi 23. Hasil penelitian yaitu variabel shopping lifestyle memiliki pengaruh yang signifikan pada impulse buying dengan t hitung 2,999 > 1,993 dan nilai signifikansi 0,004 < 0,05 . Variabel promosi berpengaruh signifikan terhadap impulse buying dengan t hitung 2,388 > 1,993 dan nilai signifikansi 0,020 < 0,05. Sedangkan variabel yang tidak memiliki pengaruh terhadap impulse buying adalah store atmosphere dengan t hitung -0.111 < 1,993 dan nilai signifikansi 0,912 > 0,05.
Generalisation to novel exemplars of learned shape categories based on visual and auditory spatial cues does not benefit from multisensory information
Authors: O’Dowd A. , Hirst R. J. , Seveso M. A. , McKenna E. M. , Newell F. N. 
Published: August 2024

Abstract
Although the integration of information across multiple senses can enhance object representations in memory, how multisensory information affects the formation of categories is uncertain. In particular, it is unclear to what extent categories formed from multisensory information benefit object recognition over unisensory inputs. Two experiments investigated the categorisation of novel auditory and visual objects, with categories defined by spatial similarity, and tested generalisation to novel exemplars. Participants learned to categorise exemplars based on visual-only (geometric shape), auditory-only (spatially defined soundscape) or audio-visual spatial cues. Categorisation to learned as well as novel exemplars was then tested under the same sensory learning conditions. For all learning modalities, categorisation generalised to novel exemplars. However, there was no evidence of enhanced categorisation performance for learned multisensory exemplars. At best, bimodal performance approximated that of the most accurate unimodal condition, although this was observed only for a subset of exemplars within a category. These findings provide insight into the perceptual processes involved in the formation of categories and have relevance for understanding the sensory nature of object representations underpinning these categories.
Huaycondo (Sur de Punilla, Córdoba, Argentina): espacios domésticos y prácticas tecnológicas en el Holoceno Tardío Final
Authors: Sario Gisela , Traktman Macarena , Costantino Florencia 
Published: August 2024

This paper presents the results of investigations in the archaeological locality Huaycondo located in the south of Punilla, Córdoba province, Argentina. The field research consisted of prospecting, test pits, and systematic excavations (using Harris matrix). The pottery and lithic material record recovered in one of the sectors, HUAY 2, was techno-morphologically approached and in the case of the ceramics also was stylistically analyzed. The results indicate that HUAY 1 was a roofed space based on the finding of holes that are linked to the placement of poles and a level of sediment compaction. In HUAY 2, activities like knapping, use, and discarding of lithic tools, manufacturing and consumption of pottery vessels and other objects made of clay associated with a level of sediment compaction were carried out. A defined compaction level was not identified in HUAY 3 therefore, the work would have to continue. In the three sectors of the site, radiocarbon dates belong to human occupations from the final late Holocene (ca. 1000-360 BP) were obtained. These domestic spaces, linked to various tasks of manufacturing, processing, consumption, use and disposal of ceramic, lithic, fauna and plant products, constitute forms of social reproduction with local and extra-regional community ties.
فعالية استخدام وسائل الإعلام المكتوبة في تنمية مهارة القراءة
Authors: Masnun Masnun , Muhammad zaini Muhammad zaini 
Published: August 2024

مستخلص البحث
أهداف هذا البحث لمعرفة مدى فعالية استخدام وسائل الإعلام المكتوبة في تنمية مهارة القراءة من النصوص العربية المعاصرة لدى طلاب الصف الأول الثانوي بمعهد دار اللغة و الدعوة بانقيل جاوى الشرقية. استخدم هذا البحث المدخل الكمى بالمنهج التجريبي. والأساليب التي استخدمها الباحثان لجمع البيانات والمعلومات المتعلقة بهذا البحث هي المقابلة والملاحظة والاختبار. ولتحليل البيانات الإحصائية استخدم الباحثان الرمز: اختبار ت (t-test) بتنفيذ البرنامج .(SPSS 12.0) وبعد أن قام الباحثان بعرض البيانات ثم تحليلها ومناقشتها استخلصا النتائج أن استـخدام وسائل الإعلام المكتوبة في تعليـم القراءة العربية لدى الطلبة في الصف الأول الثانوي بمعهد دار اللغة والدعوة فعال، وأشار إلى ذلك : (1) وجود التأثير بناء على النتيجة المحصولة من الاختبارين القبلي والبعدي في مهارة فهم المعلومات التفصيلية (محتوى النص) عن طريق اختبار ت (t-test)، أن قيمة ت الحساب (8.640)، بينما قيمة ت الجدول (2.06). وتكون النتيجة من قيمة ت الحساب أكبر من قيمة ت الجدول على مستوى الدلالة (p >0.05). وذلك لصالح النتيـجة من الاختبار البعدي بوجود فرق ذي دال إحصائي. (2) وجود التأثير بناء على النتيجة المحصولة من الاختبارين القبلي والبعدي في مهـارة فهم الأفكار الرئيسية عن طريق اختبار ت (t-test)، أن قيمة ت الحساب (8.189)، بينما قيمة ت الجـدول (2.06). وتكون النتيجة من قيمة ت الحساب أكبر من قيمة ت الجدول على مستوى الدلالة (p >0.05). وذلك لصالح النتيجة من الاختبار البعدي بوجود فرق ذي دال إحصائي.
دراسة ارتباطية بين القدرة على القراءة فى اللغة العربية وفهم المادة فى درس القرآن والحديث لدى التلاميذ
Authors: Islach M. , Sahrandi Akhmad 
Published: August 2024

الحمد لله الحي القيوم، القائل في القرآن العظيم " اقرأ باسم ربك الذي خلق. خلق الإنسان من علق. اقرأ وربك الأكرم. الذي علم بالقلم. علم الإنسان ما لم يعلم. { العلق : 1-5 } وجعل الإنسان خليفة في هذا العالم.
والصلاة والسلام على سيد الأنام سيدنا محمد صلى الله عليه وسلم. القائل في الحديث الكريم " اقرؤوا القرآن فإنه يأتي يوم القيامة شفيعا لأصحابه" (رواه مسلم) والذي أخرج الأمة الجاهلية من الظلمات إلى النور العظيم.
وبعد، فهذا بحث الدراسة الارتباطية بين القدرة على القراءة في اللغة العربية وفهم المادة في درس القرآن والحديث لدى التلاميذ في الصف الثاني بالمدرسة " الشريفة " المتوسطة الإسلامية ببرومبوع مرانجين ذماء سنة 2002 م.
بحثه الباحث للحصول على الدرجة الجامعية الأولى في قسم تعليم اللغة العربية في كلية التربية بجامعة والى سونجو الإسلامية الحكومية بسمارانج.
أسلوب كتابة الأعمال اليومية لمهارة الكتابة لطلاب الفصل الثاني الثانوي في معهد نجوم الهدى لومبوك
Authors: Agil Abdurrahman Ahmad 
Published: August 2024

الكتابة وسيلة من وسائل الاتصال اللغوي بين الأفراد. الأهداف من هذا البحث هي معرفة كيفية تطبيق الأسلوب لامتلاك مهارة الكتابة ومعرفة العوامل الدافعة والمانعة في كتابة الأعمال اليومية. إستخدم الباحث المدخل الكيفي بنوع الوصفي. أما أساليب جمع البيانات المستخدمة هي الملاحظة والمقابلة والتوثيق. ونتائج البحث المحصولة هي: 1) كيفية تطبيق الأسلوب لامتلاك مهارة الكتابة هي كتابة كل المهام المراد إنجازها خلال اليوم، و التي قد تشمل المذاكرة، والقراءة، والأعمال المنزلية، وغيرها و تخصيص الوقت أكثر واقعية لكل مهمّة ستدوّن في جدول المهام اليومي، وهذا يزيد من كمية الإنجاز و تعيين المهام ذات الأولوية للقيام بها أولاً.2) العوامل الدافعة في كتابة الأعمال اليومية هي عدم الخوف و عدم القلق و الخبرة و قبول الفشل و أما المانعة هي المشكلات التي يواجها الطلبة في الكتابة بالإضافة إلى الصعوبات في القراءة كالخوف و عدم تخصيص الوقت و اللعب.
Binding Energies and Vibrational Spectral Features of S
n
Species on Amorphous Water-ice Mantles: A Quantum Mechanical Study
Authors: Perrero Jessica , Beitia-Antero Leire , Fuente Asunción , Ugliengo Piero , Rimola Albert 
Published: August 2024

Abstract
In the denser and colder regions of the interstellar medium (ISM), gas-phase sulfur is depleted by 2 or 3 orders of magnitude with respect to its cosmic abundance. Thus, which species are the main carriers of sulfur is an open question. Recent studies have proposed S
n
species as potential sulfur reservoirs. Among the various sulfur allotropes, the most stable one is the S8 ring, detected in the asteroid Ryugu and Orgueil meteorite. Shorter species, namely S3 and S4, have been found in the comet 67P/C-G, but their presence in the ISM remains elusive. In this study, we compute the binding energies (BEs) of S
n
(n = 1–8) species on an amorphous water-ice surface model and analyze their infrared (IR) and Raman spectral features to provide data for their identification in the ISM. Our computations reveal that these species exhibit lower BEs than previously assumed and that their spectral features experience minimal shifts when adsorbed on water ice, because of the weak and nonspecific S
n
–ice interactions. Furthermore, these species display very low IR band intensities and, therefore, very accurate instruments operating in the mid-IR range are required for detecting the presence of these species in dense interstellar environments.