bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter, randomized controlled phase 2b trial of survivin vaccine SurVaxM plus adjuvant temozolomide for newly diagnosed glioblastoma (SURVIVE).
Authors: Ahluwalia Manmeet Singh , Ciesielski Michael J , Reardon David A. , Butowski Nicholas A. , Aiken Robert , Venur Vyshak , Abad Ajay Prakash , Mechtler Laszlo , Peereboom David M. , Odia Yazmin , Sinicrope Kaylyn , Boockvar John A , Brenner Andrew J. , Barbaro Marissa , Ozair Ahmad , Belal Ahmed , Qiu Jing-Xin , Khosla Atulya Aman , Casucci Danielle M. , Fenstermaker Robert Alan 
Published: July 2024

TPS2099 Background: Newly-diagnosed glioblastoma (nGBM) has a dismal prognosis with a median overall survival (OS) of nearly 16 months. nGBM cells have high expression of tumor-associated survivin protein. Survivin, localized to the cell surface through presentation by MHC class I molecules, is recognized by antibodies and cytotoxic T-lymphocytes (CTLs). A phase 2a trial (NCT02455557) demonstrated a median OS of 25.9 months in nGBM from a 15-amino acid-peptide-conjugate vaccine (SurVaxM), which also stimulated production of survivin-directed antibodies and anti-tumor CTL. This phase 2b randomized controlled trial (RCT) aims to further investigate the efficacy and safety of SurVaxM and adjuvant temozolomide for nGBM. Methods: This multicenter, placebo-controlled, investigator- and patient-blinded, in-progress RCT randomizes nGBM patients receiving standard of care to either SurVaxM (arm A) or saline placebo (arm B) in a 3:2 ratio at 11 sites. Included patients have age ≥18 years, normal organ function, Karnofsky Performance Status (KPS) ≥70, receiving surgical resection with residual MRI contrast enhancement of ≤1 cm3 within 72 hours of resection, and adjuvant temozolomide (TMZ) therapy. Patients with recurrent, multicentric, brainstem- or cerebellar-origin GBM are excluded, as well as patients on tumor-treating fields or other immunotherapies. All patients undergo 3 phases: (1) vaccine priming (VP) phase, starting within 4 weeks after completion of chemoradiation, where 4 doses of SurVaxM or Placebo are administered every 2 weeks; (2) adjuvant TMZ phase, started after ≥1 VP dose; and (3) vaccine maintenance phase, started 8 weeks after VP, with SurVaxM or placebo given every 8 weeks. TMZ phase overlaps with VP and VM phases. The primary endpoint is median OS. Assuming a 1-year survival rate of 75% in the SurVaxM arm, comparable to median OS in early phase trials, and 60% in the control arm, the required sample size consists of 137 in the SurVaxM arm and 91 in the control arm for a total sample size of 228. Accounting for dropout, the study aims to enroll 246 patients. A log-rank test stratified by KPS (70-80 and 90-100), MGMT status (methylated and unmethylated), and IDH status (mutant and wild-type) will be used for analysis. Secondary endpoints per study arm are survival at 15, 18, and 24 months, median progression-free survival, toxicity, and progression-free survival at 3, 6, and 12 months. A single sequential OS-driven interim analysis is planned when 50% of OS events (deaths) occur. 205 patients have been enrolled as of January 2024. Clinical trial information: NCT05163080 .
The role of mammals as carriers of pathogens with zoonotic potential
Authors: Tapia-Ramírez Gloria , Hernández-Aguilar Itandehui 
Published: July 2024

The COVID-19 pandemic, which occurred 4 years ago, left behind a renewed interest in the discussion of the role of mammals as carriers of pathogens with zoonotic potential. Previously, Han et al. (2016) stated that the mammalian orders with the highest number of species carrying this type of pathogens were Rodentia, Carnivora, and Chiroptera. It was also noted that the areas of the Earth with the most mammalian carriers matched the areas with high biological biodiversity, i.e., those between latitudes 40° N and 40° S (Morse et al. 2012; Allen et al. 2017). México is home to a high diversity of mammals (564 species; Sánchez-Cordero et al. 2014), and the orders mentioned above rank in the top 3 places in species richness (Rodentia 254, Chiroptera 144, and Carnivora 41). So, it is important to know their role as reservoirs or carriers of etiological agents that can spread from animals to humans. This is especially important because of the current loss rate of the original vegetation cover (for example, México lost 758,000 ha of tropical forest between 2002 and 2023; Global Forest Watch 2024) and because more people are moving into cities, which could make it easier for animals and people to come into contact with each other, potentially leading to a spillover. Given this scenario, this special issue of Therya Notes entitled “The Role of Mammals as Carriers of Pathogens with Zoonotic Potential” presents advances on the topic in the American continent through 11 notes focused on rodents, bats, and marsupials.
Molecular identification of Blastocystis sp. in urban rodents from México City
Authors: Martínez-Hernández Fernando , Ocampo Cervantes José Antonio , Tamayo-Aguilar Laura , Villalobos Guiehdani , Maravilla Pablo , Muñoz-García Claudia Irais , Rendón-Franco Emilio 
Published: July 2024

Los roedores urbanos son animales sinantrópicos que desempeñan un papel fundamental como hospederos de las enfermedades transmitidas por roedores; sin embargo, existen escasos informes de protozoos zoonóticos intestinales en estos animales. Por otro lado, Blastocystis sp. es el parásito zoonótico protozoario identificado con mayor frecuencia en estudios coprológicos de humanos a nivel mundial, y su presencia en roedores urbanos solo se ha documentado en algunos estudios. El objetivo del presente estudio fue identificar a Blastocystis sp. mediante métodos moleculares en roedores sinantrópicos de la Ciudad de México. Ochenta y cinco roedores (33 Mus musculus y 52 Rattus norvegicus) fueron atrapados en el parque público de Canal Nacional en la Ciudad de México, durante el otoño e invierno de 2020. Se obtuvieron muestras de intestino grueso de todos los animales. Se recuperó DNA de las muestras y se procesaron mediante la técnica de reacción en cadena de la polimerasa para la identificación de Blastocystis sp. Veintiún muestras fueron positivas, por lo que la prevalencia fue del 32.7 % y 12.1 % para R. norvegicus y M. musculus, respectivamente. Un reporte previo documentó una frecuencia del 31.5 % de Blastocystis sp. en pacientes de la Ciudad de México con trastornos gastrointestinales, y en concordancia con otros autores, nuestros resultados fortalecen que R. norvegicus podría ser utilizado como animal sinantrópico centinela; sin embargo, estudios que profundicen en la ecología humana y del roedor son necesarios para asegurar esto.
The family Didelphidae as a host of zoonotic pathogens
Authors: Sánchez-Cordero Víctor , Rodríguez-Moreno Ángel , Flores-Martínez José Juan , Gutiérrez-Granados Gabriel 
Published: July 2024

La familia Didelphidae ha sido frecuentemente asociada a ciclos de transmisión de enfermedades zoonóticas, por ejemplo, Leishmaniasis y Chagas. En este trabajo se realizó una revisión de la literatura científica publicada de 1994 a 2024 sobre estudios realizados en la familia Didelphidae y sus patógenos. Los resultados mostraron que, de los 5 géneros terrestres analizados de la familia Didelphidae, el 86 % reportaron a Didelphis como hospedero de diversos patógenos. En este género se han reportado mayor número de grupos, incluyendo la presencia de bacterias, virus, nematodos, hongos y helmintos, además de protozoarios que provocan las enfermedades de Chagas y Leishmaniasis. Didelphis albiventris y D. virginiana son las especies en las que más patógenos se han documentado hasta el momento (12 y 9, respectivamente). Esta información destaca la importancia de comprender el papel de la familia Didelphidae en los ciclos zoonóticos, considerando que varias especies de la familia se han adaptado a los ambientes antropizados.
Molecular detection of Trypanosoma cruzi in Mus musculus in a rural town in Mérida, Yucatán, México
Authors: Panti-May Jesús Alonso , Torres-Castro Marco , Escobedo-Ortegón Javier , Canché-Pool Elsy B. , Ruiz-Piña Hugo A. 
Published: July 2024

La tripanosomiasis americana es una enfermedad causada por el protozoario Trypanosoma cruzi y afecta aproximadamente a 6 millones de personas en las Américas. Los roedores comensales son una fuente de alimento para el vector y potenciales reservorios de T. cruzi. El objetivo del presente estudio fue estimar la prevalencia de T. cruzi en roedores comensales de la localidad rural de Molas, Yucatán, México. Se capturaron roedores en viviendas usando trampas Sherman. El DNA extraído de muestras de corazón de los roedores capturados fue utilizado para la detección de T. cruzi por medio de la técnica de PCR. Se comparó la prevalencia de T. cruzi considerando el sexo y edad de los roedores con la prueba de Chi-cuadrada. Un total de 114 ratones Mus musculus fueron atrapados. La prevalencia de T. cruzi fue 21.1 % (n = 24) en los individuos examinados. La comparación de las prevalencias de T. cruzi entre machos y hembras y entre los adultos y juveniles de M. musculus no arrojó diferencias estadísticas significativas (P > 0.05). La prevalencia de T. cruzi en M. musculus fue alta, en comparación con otros estudios previos en México, y la infección se presentó independientemente del sexo y la edad de los roedores. Estos resultados demuestran que M. musculus participa en el ciclo biológico de T. cruzi en Molas. Es necesario realizar mayores estudios para entender el tipo de participación (e.g., reservorio) de estos roedores en la dinámica de transmisión de este parásito.
First record of cinnamon coloration in opossum Didelphis sp. in México
Authors: Tenorio-Rodríguez Paola A. , Cab-Sulub Leticia , Moreno-Figueroa Luis Daniel 
Published: July 2024

La pigmentación desempeña un papel vital en la coloración de los vertebrados, influenciada por factores genéticos y ambientales. El albinismo, leucismo, melanismo y flavismo son anomalías de color en los vertebrados. Este manuscrito documenta el primer registro en México de flavismo en Didelphis sp., capturado en la Península de Yucatán. En julio de 2023, se rescataron 2 crías de zarigüeya machos de un jardín en una zona urbanizada en Chuburná Hidalgo, en Yucatán, México, y se transportaron a un refugio de rehabilitación en Mérida. Uno de ellos mostraba un pelaje oscuro típico, mientras que el otro mostraba una coloración canela. Tras la crianza, las zarigüeyas fueron liberadas en la naturaleza después de alcanzar el tamaño y peso apropiados. El individuo con coloración canela mantuvo la coloración y exhibió un pelaje de tono naranja-marrón. La pigmentación canela observada en la zarigüeya probablemente no sea solo el resultado de una mutación genética que afecta el metabolismo de la melanina, sino que también esté influenciada por otras presiones evolutivas en esta región. La coloración anómala en vertebrados puede estar vinculada a factores como la diversidad genética, la calidad del hábitat o la contaminación ambiental. El aislamiento poblacional por la fragmentación del hábitat podría jugar un papel significativo. Se necesitan estudios genéticos y poblacionales para comprender completamente el impacto de estos factores en la población. A pesar de los riesgos asociados, la adaptabilidad de las zarigüeyas parece garantizar su supervivencia, como se ha visto en otros casos documentados.
Self-health promotion: A study on the mode of acquiring sports health knowledge and skills among older adults members of sports communities
Authors: Wei Ye 
Published: July 2024

Objective
The research aims to construct a mode and the pathway relationships of acquiring sports health knowledge and skills among members of older adults sports communities.

Method
The research was primarily conducted through random sampling, purposive sampling, and questionnaire surveys. A sample of 457 older adults from Luoyang City was selected as the research subjects. Exploratory analysis and Structural Equation Modeling (SEM) were conducted by employing SPSS 26.0 and Amos 26.0 software(Exploratory analysis and structural equation analysis).

Results
The study indicates that the influence of older adults sports community culture on the pursuit of sports health knowledge and skills is statistically significant (β = 0.69, P<0.001); the influence of sports community culture on the motivation to enhance sports health knowledge and skills is statistically significant (β = 0.32, P<0.001); the influence of the pursuit of sports health knowledge and skills on the motivation to enhance these knowledge and skills is statistically significant (β = 0.47, P<0.001); the influence of the motivation to enhance sports health knowledge and skills on the behavior of acquiring these knowledge and skills is statistically significant (β = 0.60, P<0.001); both the pursuit of sports health knowledge and skills and the motivation to enhance these knowledge and skills serve as mediating variables.

Conclusion
The more harmonious and positive the sports community culture is, the stronger the sense of pursuing health and the motivation to acquire knowledge are among older adults. The stronger the health pursuit among older adults, the higher their motivation to enhance sports health knowledge and skills shows. Furthermore, the higher the motivation of older adults to enhance sports health knowledge and skills is, the more efficient their behavior in acquiring these knowledge and skills becomes. The motivation to enhance sports health knowledge and skills serves as a complete mediating variable in this process.
“The straw that broke the camel’s back”: An analysis of racialized women clinicians’ experiences providing diabetes care
Authors: Sivakumar Arani , Rana Simrit , Rofaiel David , Ahmad Tehmina , Hari Shriya , Yu Catherine H. 
Published: July 2024

Introduction
Racialized women clinicians (RWCs) experience the brunt of unfair racial and gendered expectations, which is a direct result of their visible identity. Our study sought to understand how these experiences intersect to impact the personal and professional well-being of RWCs, and their approach to diabetes care.

Methods
Data were collected from 24 RWCs working within Canadian diabetes care settings, who participated in semi-structured, one-on-one interviews conducted from April 2021 to September 2021. The data were qualitatively analyzed using thematic analysis to develop emergent themes, and interactions were explored using the socioecological model (SEM), adapted to our study context.

Results
We identified three themes: (1) Discordance between self-identity and relational identity impacted how RWCs interacted with others, and how others interacted with them; (2) Tokenistic, “inclusive” organizational policies/practices and inherently racist and sexist social norms permitted acts of discrimination and led to the systematic othering and exclusion of RWCs within the workplace; and (3) Differential treatment of RWCs had both positive and negative impacts on participants’ relational, workplace and self-identity. Using the SEM, we also found that differential treatment of RWCs stems from upstream policies, structures, and social norms, percolating through different levels of the SEM, including work environments and communities, which eventually impacts one’s relational identity, as well as one’s perception of oneself.

Conclusion
The differential treatment of RWCs arises predominantly from macro systems of the work environment. The burden to address these disparities must be shifted to the source (i.e., namely systems) by implementing interventions that equitably value diversity efforts, institute policies of accountability and correction of implicit biases, and prioritize an inclusive culture broadly across faculty and leadership.
Breathing–Swallowing discoordination after definitive chemoradiotherapy for head and neck cancers is associated with aspiration pneumonia
Authors: Yoshida Takuya , Yagi Naomi , Ogawa Takenori , Nakanome Ayako , Ohkoshi Akira , Katori Yukio , Oku Yoshitaka 
Published: July 2024

Purpose
Swallowing dysfunction and the risk of aspiration pneumonia are frequent clinical problems in the treatment of head and neck squamous cell carcinomas (HNSCCs). Breathing–swallowing coordination is an important factor in evaluating the risk of aspiration pneumonia. To investigate breathing–swallowing discoordination after chemoradiotherapy (CRT), we monitored respiration and swallowing activity before and after CRT in patients with HNSCCs.

Methods
Non-invasive swallowing monitoring was prospectively performed in 25 patients with HNSCCs treated with CRT and grade 1 or lower radiation-induced dermatitis. Videoendoscopy, videofluoroscopy, Food Intake LEVEL Scale, and patient-reported swallowing difficulties were assessed.

Results
Of the 25 patients selected for this study, four dropped out due to radiation-induced dermatitis. The remaining 21 patients were analyzed using a monitoring system before and after CRT. For each of the 21 patients, 405 swallows were analyzed. Swallowing latency and pause duration after the CRT were significantly extended compared to those before the CRT. In the analysis of each swallowing pattern, swallowing immediately followed by inspiration (SW-I pattern), reflecting breathing–swallowing discoordination, was observed more frequently after CRT (p = 0.0001). In 11 patients, the SW-I pattern was observed more frequently compared to that before the CRT (p = 0.00139). One patient developed aspiration pneumonia at 12 and 23 months after the CRT.

Conclusion
The results of this preliminary study indicate that breathing–swallowing discoordination tends to increase after CRT and could be involved in aspiration pneumonia. This non-invasive method may be useful for screening swallowing dysfunction and its potential risks.
Impact of the COVID-19 pandemic on the complete rehabilitation journey of hip fracture patients in Italy: From surgical admission to rehabilitation facility discharge
Authors: Elhadidy Heba Safwat Mhmoued Abdo , Politano Gianfranco , Onorati Roberta , Catozzi Dario , Gianino Maria Michela 
Published: July 2024

Introduction
The COVID-19 pandemic led to a significant reorganization of health services, potentially affecting the quality of care for major public health concerns such as proximal femoral fractures. This study aimed to investigate potential changes in the timing of various steps in the patient journey after a hip fracture during the pandemic in Piedmont, a region in Northern Italy.

Methods
A retrospective study was conducted on the discharge records of patients aged 65 or older who were admitted for hip surgery following a femur fracture in 2019 and 2020. The study examined four-time steps: duration from hospital admission to surgery, length of hospital stay, interval between hospital discharge and admission to the rehabilitation facility, and duration of stay at the rehabilitation facility. To mitigate biases linked to sex and age factors, groups well-balanced across 2019 and 2020 were created using propensity score estimation.

Results
The dataset consisted of two cohorts of 583 patients each for the years 2019 and 2020. The average duration from admission to surgery was approximately 1.9 days in both years, with 75% of patients undergoing surgery within 2 days of hospital admission. The average hospital stay reduced from 13.49 days in 2019 to 11.34 days in 2020. The gap between hospital discharge and admission to rehabilitation was approximately 10–12 days, and the average duration of stay at the rehabilitation facility was about 31.6 days.

Discussion
The study indicates that healthcare systems can exhibit resilience and adaptability, even during a global pandemic, to ensure high-quality and safe standards of care. However, further long-term studies are needed to fully understand the pandemic’s impact on primary health outcomes following hip replacement surgery and subsequent rehabilitation. The potential role of telemedicine in reducing the time between steps also warrants further investigation.
Prevalence and risk factors of gastroesophageal reflux disease in Iran: A cross-sectional analysis from the PERSIAN cohort
Authors: Sadeghi Anahita , Boustani Paria , Mehrpour Ali , Asgari Ali Ali , Sharafkhah Maryam , Yazdanbod Abbas , Somi Mohammad Hossein , Nejatizadeh Azim , Moradpour Farhad , Rezaeian Mehdi , Mansour-Ghanaei Fariborz , Shahriari Arman , Fattahi Mohammad Reza , Hamzeh Behrooz , Hosseini Seyed Vahid , Kahnooji Mahmood , Gohari Ali , Khosravifarsani Mohammadreza , Azadeh Hossein , Pashaei Mohammad Reza , Sheibani Eshagh Moradi , Fallahzadeh Hossein , Bakhshipour Alireza , Poustchi Hossein , Malekzadeh Reza 
Published: July 2024

Background
This study assessed the prevalence of gastroesophageal reflux disease (GERD) in a general adult population in Iran. The association between GERD and various factors was also evaluated.

Methods
We performed a cross-sectional study on 163,018 individuals aged over 35 who were enrolled in the PERSIAN cohort. GERD was defined as the occurrence of heartburn and/or regurgitation symptoms at least several days a month. Survey design analysis for pooled data was performed and multiple regression analysis was conducted to determine the independent risk factors for GERD.

Results
The prevalence of GERD in our study was estimated at 21.86% (95% confidence interval:17.4%-36.4%). The mean age of the participants was 49.84 years±9.25 (35–70) and 44.75% of the participants were male. Symptoms of heartburn and regurgitation were reported in 18.65% (n: 29,170) and 6.06% (n: 9,717) of participants, respectively. In the multivariate analysis, several factors were found to be associated with a higher prevalence of GERD: female sex, age >50, current smoking, opium use, weekly consumption of fried foods, frequent consumption of hot tea, less than 6 hours of sleep per night, psychiatric disorders, usage of NSAIDs, and poor oral hygiene, were associated with a higher prevalence of GERD. Conversely, higher education levels and average physical activity were found to be less commonly associated with GERD.

Conclusion
We found a relatively high prevalence of GERD (21.86%) in this population-based study in Iran. By identifying modifiable risk factors, this research offers opportunities for targeted interventions and lifestyle modifications to reduce the burden of GERD.