bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gamma Knife radiosurgery for posterior fossa meningiomas: a multicenter study
Authors: Sheehan Jason P. , Starke Robert M. , Kano Hideyuki , Barnett Gene H. , Mathieu David , Chiang Veronica , Yu James B. , Hess Judith , McBride Heyoung L. , Honea Norissa , Nakaji Peter , Lee John Y. K. , Rahmathulla Gazanfar , Evanoff Wendi A. , Alonso-Basanta Michelle , Lunsford L. Dade 
Published: April 2015

OBJECT
Posterior fossa meningiomas represent a common yet challenging clinical entity. They are often associated with neurovascular structures and adjacent to the brainstem. Resection can be undertaken for posterior fossa meningiomas, but residual or recurrent tumor is frequent. Stereotactic radiosurgery (SRS) has been used to treat meningiomas, and this study evaluates the outcome of this approach for those located in the posterior fossa.

METHODS
At 7 medical centers participating in the North American Gamma Knife Consortium, 675 patients undergoing SRS for a posterior fossa meningioma were identified, and clinical and radiological data were obtained for these cases. Females outnumbered males at a ratio of 3.8 to 1, and the median patient age was 57.6 years (range 12–89 years). Prior resection was performed in 43.3% of the patient sample. The mean tumor volume was 6.5 cm3, and a median margin dose of 13.6 Gy (range 8–40 Gy) was delivered to the tumor.

RESULTS
At a mean follow-up of 60.1 months, tumor control was achieved in 91.2% of cases. Actuarial tumor control was 95%, 92%, and 81% at 3, 5, and 10 years after radiosurgery. Factors predictive of tumor progression included age greater than 65 years (hazard ratio [HR] 2.36, 95% CI 1.30–4.29, p = 0.005), prior history of radiotherapy (HR 5.19, 95% CI 1.69–15.94, p = 0.004), and increasing tumor volume (HR 1.05, 95% CI 1.01–1.08, p = 0.005). Clinical stability or improvement was achieved in 92.3% of patients. Increasing tumor volume (odds ratio [OR] 1.06, 95% CI 1.01–1.10, p = 0.009) and clival, petrous, or cerebellopontine angle location as compared with petroclival, tentorial, and foramen magnum location (OR 1.95, 95% CI 1.05–3.65, p = 0.036) were predictive of neurological decline after radiosurgery. After radiosurgery, ventriculoperitoneal shunt placement, resection, and radiation therapy were performed in 1.6%, 3.6%, and 1.5%, respectively.

CONCLUSIONS
Stereotactic radiosurgery affords a high rate of tumor control and neurological preservation for patients with posterior fossa meningiomas. Those with a smaller tumor volume and no prior radiation therapy were more likely to have a favorable response after radiosurgery. Rarely, additional procedures may be required for hydrocephalus or tumor progression.
Survival in patients treated for anaplastic meningioma
Authors: Moliterno Jennifer , Cope William P. , Vartanian Emma D. , Reiner Anne S. , Kellen Roselyn , Ogilvie Shahiba Q. , Huse Jason T. , Gutin Philip H. 
Published: April 2015

OBJECT
While most meningiomas are benign, 1%–3% display anaplastic features, with little current understanding regarding the molecular mechanisms underlying their formation. In a large single-center cohort, the authors tested the hypothesis that two distinct subtypes of anaplastic meningiomas, those that arise de novo and those that progress from lower grade tumors, exist and exhibit different clinical behavior.

METHODS
Pathology reports and clinical data of 37 patients treated between 1999 and 2012 for anaplastic meningioma at Memorial Sloan–Kettering Cancer Center (MSKCC) were retrospectively reviewed. Patients were divided into those whose tumors arose de novo and those whose tumors progressed from previously documented benign or atypical meningiomas.

RESULTS
Overall, the median age at diagnosis was 59 years and 57% of patients were female. Most patients (38%) underwent 2 craniotomies (range 1–5 surgeries) aimed at gross-total resection (GTR; 59%), which afforded better survival when compared with subtotal resection according to Kaplan-Meier estimates (median overall survival [OS] 3.2 vs 1.3 years, respectively; p = 0.04, log-rank test). Twenty-three patients (62%) presented with apparently de novo anaplastic meningiomas. Compared with patients whose tumors had progressed from a lower grade, those patients with de novo tumors were significantly more likely to be female (70% vs 36%, respectively; p = 0.04), experience better survival (median OS 3.0 vs 2.4 years, respectively; p = 0.03, log-rank test), and harbor cerebral hemispheric as opposed to skull base tumors (91% vs 43%, respectively; p = 0.002).

CONCLUSIONS
Based on this single-center experience at MSKCC, anaplastic meningiomas, similar to glial tumors, can arise de novo or progress from lower grade tumors. These tumor groups appear to have distinct clinical behavior. De novo tumors may well be molecularly distinct, which is under further investigation. Aggressive GTR appears to confer an OS advantage in patients with anaplastic meningioma, and this is likely independent of tumor progression status. Similarly, those patients with de novo tumors experience a survival advantage likely independent of extent of resection.
Timing of pollen release and stigma receptivity period of Piper vicosanum: New insights into sexual reproduction of the genus
Authors: Valentin‐Silva Adriano , Coelho Victor Peçanha de Miranda , Ventrella Marília Contin , Vieira Milene Faria 
Published: April 2015

• Premise of the study: Dichogamy is a common characteristic among angiosperms, including Piper species. In this genus, the tiny flowers are morphologically similar and have an asynchronous stamen development. However, there is no information on the duration of stigma receptivity and whether it overlaps with pollen release. To better understand mechanisms of floral function in Piper vicosanum, we provide a detailed characterization of the timing of pollen release from the four stamens and the period of stigma receptivity and exposure mode of the receptive areas.• Methods: We investigated plants of a natural population in a semideciduous seasonal forest (Viçosa, Minas Gerais State, southeastern Brazil), based on chemical tests, light microscopy, and scanning electron microscopy analyses.• Key results: Incomplete protogyny—a mechanism that favors outcrossing—was recorded. The period of stigma receptivity was long (14 d), and the sequential exposure and senescence of stigmatic papillae occurred gradually and in a basipetal direction. Pollen release began 2–6 d after the beginning of the pistillate phase, with an average pollen viability of 87.7%, during the bisexual flower phase. Pollen was released for up to 6 d and occurred in one stamen at a time. The fruit set observed in tests of self‐pollination indicated self‐compatibility.• Conclusions: The gradual and sequential exposure of stigmatic papillae in P. vicosanum flowers is described here as the mechanism for the long duration of receptivity. Anther development and pollen release were also sequential. These findings are yet unreported reproductive characteristics of the genus and offer new perspectives for future studies on the floral biology of other Piper species.
Multiplexed‐shotgun‐genotyping data resolve phylogeny within a very recently derived insular lineage
Authors: Mort Mark E. , Crawford Daniel J. , Kelly John K. , Santos‐Guerra Arnoldo , Menezes de Sequeira Miguel , Moura Mónica , Caujapé‐Castells Juli 
Published: April 2015

• Premise of the study: Endemic plants on oceanic islands have long served as model systems for studying patterns and processes of evolution. However, phylogenetic studies of island plants frequently illustrate a decoupling of molecular divergence and ecological/morphological diversity, resulting in phylogenies lacking the resolution required to interpret patterns of evolution in a phylogenetic context. The current study uses the primarily Macaronesian flowering plant genus Tolpis to illustrate the utility of multiplexed shotgun genotyping (MSG) for resolving relationships at relatively deep (among archipelagos) and very shallow (within archipelagos) nodes in this small, yet diverse insular plant lineage that had not been resolved with other molecular markers.• Methods: Genomic libraries for 27 accessions of Macaronesian Tolpis were generated for genotyping individuals using MSG, a form of reduced‐representation sequencing, similar to restriction‐site‐associated DNA markers (RADseq). The resulting data files were processed using the program pyRAD, which clusters MSG loci within and between samples. Phylogenetic analyses of the aligned data matrix were conducted using RAxML.• Key results: Analysis of MSG data recovered a highly resolved phylogeny with generally strong support, including the first robust inference of relationships within the highly diverse Canary Island clade of Tolpis.• Conclusions: The current study illustrates the utility of MSG data for resolving relationships in lineages that have undergone recent, rapid diversification resulting in extensive ecological and morphological diversity. We suggest that a similar approach may prove generally useful for other rapid plant radiations where resolving phylogeny has been difficult.
À quoi réfléchit le praticien réflexif ?
Authors: Schneuwly Bernard 
Published: April 2015

Le « praticien réflexif » a connu un immense succès dans la formation des enseignants, en Amérique du Nord puis en Europe. La contribution présente la visée originelle du concept : un combat contre la technologie rationnelle en vue de réhabiliter les professions. Cette réhabilitation paie cependant le prix d’une abstraction des outils et des objets de profession ; la réflexion pure est mise à la place du travail concret du professionnel. C’est précisément cet accent sur la réflexion en tant que telle qui facilite l’entrée du concept dans les conceptions de la formation des enseignants : là aussi, abstraction est faite de l’objet du travail des enseignants, le savoir. Ceci caractérise l’usage du concept dans les pays francophones, centré sur certains aspects de la condition de l’exercice de la profession : la relation pédagogique. Les travaux se servant du concept s’inspirent en général du paradigme de l’éducation nouvelle qui propose selon le mode de la négation abstraite, un autre qui viendrait remplacer les pratiques classiques d’enseignement.
Philosophie weilienne et théologie chrétienne chez Henri Bouillard
Authors: Castro Michel 
Published: April 2015

La rencontre du philosophe Eric Weil permet au théologien Henri Bouillard de mettre en œuvre son concept de théologie fondamentale, notamment à propos des rapports entre politique et christianisme, et entre philosophie et foi ; mais elle le conforte aussi à ne pas relever les défis de son époque : les théologies politiques et les sciences humaines.
Gratuité
Authors: Gilbert Paul 
Published: April 2015

La philosophie contemporaine, particulièrement en France et en Italie, s’est attachée au thème du ‘don’ ; s’ensuit un renouvellement de la ‘philosophie première’. L’article parcourt quelques textes des dernières années qui en présentent différents aspects : la gratuité (que Mauss avait approchée mais qui prend un poids nouveau dans la phénoménologie récente), le sacrifice (que notre culture n’entend plus qu’en faveur du progrès de l’individu), la reconnaissance (à laquelle Ricœur a consacré son dernier ouvrage de 2004). Tout don tire son originalité de l’excès de son origine ; il n’implique donc aucun effacement du donateur, ni non plus aucune imposition de soi au donataire ; le donateur demeure présent en son don, éveillant la reconnaissance du destinataire qu’il aura préalablement reconnu lui-même et déjà respecté.
Entrer en reconnaissance avec Paul Ricœur : un hommage
Authors: Amherdt François-Xavier 
Published: April 2015

Le dernier ouvrage de Paul Ricœur, intitulé Parcours de la reconnaissance , nous invite lui-même à la gratitude. C’est en héritiers endettés que nous nous situons face à l’œuvre immense du philosophe réformé décédé l’an dernier : son goût du « dialogue universel » avec la plupart des courants de pensée du XX e siècle, son art de l’admiration sans cesse cultivée contre l’ennui, sa volonté de décentrement du cogito sur la « voie longue de l’herméneutique », son humilité d’auditeur de la poétique biblique en sa polyphonie multiforme l’ont maintenu jeune jusqu’au bout de son existence. Dans la joie du oui prononcé au cœur de la tristesse du fini.
La complémentarité irréductible
Authors: Fernández Víctor M. 
Published: April 2015

L’A. considère que la principale racine théologique de la Shoah consiste à déclarer non nécessaire ou non pertinent l’apport de la religion juive après Jésus Christ. L’article parcourt cinq modes d’approche chrétienne du judaïsme, qui demeurent insuffisantes pour démonter cette erreur. Ensuite, l’A. investit pleinement le cadre de l’herméneutique biblique pour dénoncer le danger des modèles d’accomplissement, d’opposition et de substitution, qu’on utilise encore pour expliquer la relation du Nouveau Testament à l’Ancien. Finalement, il propose un modèle alternatif : la « complémentarité irréductible », qui manifeste la pertinence actuelle de la lecture juive de la Bible, sans nier la légitimité d’une lecture christologique.
L’argile modelée par le Christ
Authors: Dumas Bertrand 
Published: April 2015

Selon Grégoire de Nysse, la corporéité est une dimension constitutive de l’homme, et la vraie opposition n’est pas à mettre entre corps et esprit, mais entre (re)Créateur et créatures. Le Christ, Verbe fait chair, mort et ressuscité pour nous, nous ouvre les yeux sur les limites et le sens de notre corporéité présente ; et il l’achève par la résurrection. Au milieu de courants philosophiques opposés, notre auteur fait ainsi droit à une intuition majeure de la philosophie (« l’essentiel est invisible pour les yeux ») sans pour autant discréditer notre corps actuel, ni en faire un absolu. Au rebours des tendances païennes qui sommeillent toujours en nous, nous pouvons nous réjouir car il est fini, « l’esclavage de la corruption » (Rm 8,21). Notre corps est en croissance et Chronos, assumé par le Christ, ne dévore plus ses enfants.
DEC205+ Dendritic Cell–Targeted Tolerogenic Vaccination Promotes Immune Tolerance in Experimental Autoimmune Arthritis
Authors: Spiering Rachel , Margry Bram , Keijzer Chantal , Petzold Cathleen , Hoek Aad , Wagenaar-Hilbers Josée , van der Zee Ruurd , van Eden Willem , Kretschmer Karsten , Broere Femke 
Published: April 2015

Abstract
Previous studies in mouse models of autoimmune diabetes and encephalomyelitis have indicated that the selective delivery of self-antigen to the endocytic receptor DEC205 on steady-state dendritic cells (DCs) may represent a suitable approach to induce Ag-specific immune tolerance. In this study, we aimed to examine whether DEC205+ DC targeting of a single immunodominant peptide derived from human cartilage proteoglycan (PG) can promote immune tolerance in PG-induced arthritis (PGIA). Besides disease induction by immunization with whole PG protein with a high degree of antigenic complexity, PGIA substantially differs from previously studied autoimmune models not only in the target tissue of autoimmune destruction but also in the nature of pathogenic immune effector cells. Our results show that DEC205+ DC targeting of the PG peptide 70–84 is sufficient to efficiently protect against PGIA development. Complementary mechanistic studies support a model in which DEC205+ DC targeting leads to insufficient germinal center B cell support by PG-specific follicular helper T cells. Consequently, impaired germinal center formation results in lower Ab titers, severely compromising the development of PGIA. Overall, this study further corroborates the potential of prospective tolerogenic DEC205+ DC vaccination to interfere with autoimmune diseases, such as rheumatoid arthritis.
Obesity Increases Mortality and Modulates the Lung Metabolome during Pandemic H1N1 Influenza Virus Infection in Mice
Authors: Milner J. Justin , Rebeles Jenny , Dhungana Suraj , Stewart Delisha A. , Sumner Susan C. J. , Meyers Matthew H. , Mancuso Peter , Beck Melinda A. 
Published: April 2015

Abstract
Obese individuals are at greater risk for hospitalization and death from infection with the 2009 pandemic H1N1 influenza virus (pH1N1). In this study, diet-induced and genetic-induced obese mouse models were used to uncover potential mechanisms by which obesity increases pH1N1 severity. High-fat diet–induced and genetic-induced obese mice exhibited greater pH1N1 mortality, lung inflammatory responses, and excess lung damage despite similar levels of viral burden compared with lean control mice. Furthermore, obese mice had fewer bronchoalveolar macrophages and regulatory T cells during infection. Obesity is inherently a metabolic disease, and metabolic profiling has found widespread usage in metabolic and infectious disease models for identifying biomarkers and enhancing understanding of complex mechanisms of disease. To further characterize the consequences of obesity on pH1N1 infection responses, we performed global liquid chromatography–mass spectrometry metabolic profiling of lung tissue and urine. A number of metabolites were perturbed by obesity both prior to and during infection. Uncovered metabolic signatures were used to identify changes in metabolic pathways that were differentially altered in the lungs of obese mice such as fatty acid, phospholipid, and nucleotide metabolism. Taken together, obesity induces distinct alterations in the lung metabolome, perhaps contributing to aberrant pH1N1 immune responses.
SCARB2/LIMP-2 Regulates IFN Production of Plasmacytoid Dendritic Cells by Mediating Endosomal Translocation of TLR9 and Nuclear Translocation of IRF7
Authors: Guo Hao , Zhang Jialong , Zhang Xuyuan , Wang Yanbing , Yu Haisheng , Yin Xiangyun , Li Jingyun , Du Peishuang , Plumas Joel , Chaperot Laurence , Chen Jianzhu , Su Lishan , Liu Yongjun , Zhang Liguo 
Published: April 2015

Abstract
Scavenger receptor class B, member 2 (SCARB2) is essential for endosome biogenesis and reorganization and serves as a receptor for both β-glucocerebrosidase and enterovirus 71. However, little is known about its function in innate immune cells. In this study, we show that, among human peripheral blood cells, SCARB2 is most highly expressed in plasmacytoid dendritic cells (pDCs), and its expression is further upregulated by CpG oligodeoxynucleotide stimulation. Knockdown of SCARB2 in pDC cell line GEN2.2 dramatically reduces CpG-induced type I IFN production. Detailed studies reveal that SCARB2 localizes in late endosome/lysosome of pDCs, and knockdown of SCARB2 does not affect CpG oligodeoxynucleotide uptake but results in the retention of TLR9 in the endoplasmic reticulum and an impaired nuclear translocation of IFN regulatory factor 7. The IFN-I production by TLR7 ligand stimulation is also impaired by SCARB2 knockdown. However, SCARB2 is not essential for influenza virus or HSV-induced IFN-I production. These findings suggest that SCARB2 regulates TLR9-dependent IFN-I production of pDCs by mediating endosomal translocation of TLR9 and nuclear translocation of IFN regulatory factor 7.
Beperkingen aan en dilemma’s van de slachtoffergerichte aanpak van mensenhandel; een blik op arbeidsuitbuiting.
Authors: Cleiren Tineke , van der Leun Joanne , Van Meeteren Masja 
Published: April 2015

Limitations and dilemmas of a victim-oriented approach to human trafficking for labour exploitation
In their article on the victim orientation in the combat against human trafficking – in particular labour exploitation – Cleiren, Van der Leun and Van Meeteren highlight the limitations of the protection of victims in practice. Based on a brief legal analysis and a secondary reading of the empirical literature, they conclude that the rights of victims remain subordinate to the main aims of the relevant legal domains: criminal law and immigration law. In addition, the practices-based analysis shows a mismatch between a victim-oriented approach and preferences and perceptions of many migrants involved as well as existing tensions between different legal domains.
Les territoires de la coopération : le cas de la Coopérative de développement régional Outaouais-Laurentides
Authors: Chiasson Guy , Léon Sara , Lalonde Claudine , Duguay Patrick 
Published: April 2015

Bon nombre de travaux de recherche contemporains font une place centrale au « territoire » dans leur explication du développement régional. Selon ces travaux, le territoire serait un espace de collaboration où les entreprises privées peuvent trouver des ressources stratégiques essentielles à leur dynamisme. Cependant, cette perspective n’envisage pas la contribution d’entreprises collectives comme les entreprises d’économie sociale et les coopératives, de sorte que l’on connaît mal le rapport de ces dernières avec le territoire. C’est sur ce rapport que nous voulons réfléchir, par l’entremise d’une étude sur la Coopérative de développement régional Outaouais-Laurentides (CDROL) et tout particulièrement sur la mise sur pied de la Laiterie de l’Outaouais, dans laquelle la CDROL a été fortement impliquée. Notre analyse de ce cas suggère la capacité des coopératives de développement régional (CDR) à mobiliser deux types de ressources territoriales. Si, à l’instar des entreprises privées, les CDR peuvent mobiliser des « ressources stratégiques » issues de la collaboration entre les acteurs clés du territoire, elles peuvent également mobiliser des ressources « citoyennes », ignorées par les travaux sur les entreprises privées.
Assessing long‐term postseismic deformation following the M7.2 4 April 2010, El Mayor‐Cucapah earthquake with implications for lithospheric rheology in the Salton Trough
Authors: Spinler Joshua C. , Bennett Richard A. , Walls Chris , Lawrence Shawn , González García J. Javier 
Published: April 2015

AbstractThe 4 April 2010 Mw 7.2 El Mayor‐Cucapah (EMC) earthquake provides the best opportunity to date to study the lithospheric response to a large (>M6) magnitude earthquake in the Salton Trough region through analysis of Global Positioning System (GPS) data. In conjunction with the EarthScope Plate Boundary Observatory (PBO), we installed six new continuous GPS stations in the months following the EMC earthquake to increase station coverage in the epicentral region of northern Baja California, Mexico. We modeled the pre‐EMC deformation field using available campaign and continuous GPS data for southern California and northern Baja California and inferred a pre‐EMC secular rate at each new station location. Through direct comparison of the pre‐ and post‐EMC secular rates, we calculate long‐term changes associated with viscoelastic relaxation in the Salton Trough region. We fit these velocity changes using numerical models employing an elastic upper crustal layer underlain by a viscoelastic lower crustal layer and a mantle half‐space. Forward models that produce the smallest weighted sum of squared residuals have an upper mantle viscosity in the range 4–6 × 1018 Pa s and a less well‐resolved lower crustal viscosity in the range 2 × 1019 to 1 × 1022 Pa s. A high‐viscosity lower crust, despite high heat flow in the Salton Trough region, is inconsistent with felsic composition and might suggest accretion of mafic lower crust associated with crustal spreading obscured by thick sedimentary cover.