bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Factors Affecting Attainment of Glycemic Control in Asian Americans With Diabetes in a Culturally Specific Program
Authors: Le Hung , Wong Sophia , Iftikar Tracy , Keenan Hillary , King George L. , Hsu William C. 
Published: June 2013

Purpose The purpose of this study is to examine the effectiveness of a culturally specific pilot clinic for Asian Americans (AA) in reaching glycemic target and to characterize factors affecting the attainment of glycemic control in comparison with white counterparts. Methods This electronic health record review included all new AA patients with type 2 diabetes (n = 109) in a culturally specific program and a randomly selected sample of new white patients with type 2 diabetes (n = 218) in the adult clinic within the same time period and diabetes center. Results AA and whites had a comparable proportion of patients with A1C ≤7% (32.1%, 34.9%; P = .621) at baseline and after 12 months of care (48.6%, 56.0%; P = .210), with a similar A1C decline (–0.9% ± 1.6%, –0.8% ± 1.7%, P = .710) by 12 months. Factors associated with the lack of success in reaching target in AA but not in whites included older age, lower educational attainment, less likelihood of having health insurance, and a need for more educational visits. The percentage of AA reaching A1C ≤7%, as compared to whites, worsened among those with highest initial A1C when stratified by ascending quartiles (96.7% vs 85.2%, P = .101; 61.9% vs 58.9%, P = .813; 24.0% vs 37.7%, P = .230; 15.2% vs 35.4%, P = .044). Conclusion While a culturally specific diabetes program in a specialty setting achieved a similar glycemic outcome for AA compared with whites, reasons for not reaching glycemic target differed. The findings suggest that the elimination of diabetes disparities requires not only culturally and linguistically specific programs, but must also identify and address the socio-environmental differences unique to each population.
Persistent Barriers and Strategic Practices
Authors: Rendle Katharine A. S. , May Suepattra G. , Uy Visith , Tietbohl Caroline K. , Mangione Carol M. , Frosch Dominick L. 
Published: June 2013

Purpose The purpose of this study was to explore the everyday barriers to and practices of low-income patients managing their diabetes. Methods The study team conducted semistructured qualitative interviews with 20 patients with type 2 diabetes who were receiving care at safety-net clinics in Southern California. Transcripts were analyzed using grounded theory to identify emergent themes across participants. Results Participants described managing diabetes with limited financial resources as often a game of balance and negotiation, whereby purchasing healthy foods is abandoned because of a more pressing concern in their life. Although participants described strategic attempts at incorporating healthy dietary practices for diabetes management into their daily decisions, these efforts were significantly impeded by the existence of persistent and seemingly insurmountable barriers. Conclusions Although the challenges that low-income patients face in managing their diabetes may seem insurmountable at times, there are several ways that health care providers can help reduce the burden of these challenges, including tailoring their recommendations to incorporate the everyday socioeconomic environment of patients and engaging in clear, open communication with patients.
Human albumin in extracorporeal prime: effect on platelet function and bleeding
Authors: Kamra C , Beney A 
Published: June 2013

Purpose: Synthetic starches have been positioned as an equivalent substitute for human albumin in extracorporeal prime, with both providing osmotic and oncotic pressure. Another effect of albumin is its ability to coat the synthetic surfaces of an extracorporeal circuit with a biopassivating protein monolayer. Whether this protein biopassivation has any benefit to the patient, assessed by platelet count, platelet function and 24-hour bleeding rate, is considered. Methods: Patients presenting for coronary artery bypass at a Canadian tertiary care hospital were randomized into two groups until a final study size of 20 patients was obtained. The Study Group received 2.5 g of human albumin in the extracorporeal prime and the Control Group remained protein free. Both groups included Voluven 6% as a synthetic starch. Blood samples were obtained at three intervals; Pre-bypass, During bypass (30 minutes after initiation of bypass), and Post-bypass. These samples were assayed for platelet function, platelet count and hemoglobin. Chest tube drainage over a 24-hour period was monitored. Results: Platelet count was significantly higher in the During sample in the Study Group (196 ± 56.5 x 109/ml versus 160 ± 18.5 x 109/ml, p<0.05), however, this difference was no longer significant with the Post-bypass sample (135 ±36.0 x 109/mL versus 127 ±19 x 109/mL). Platelet function assays (PFA) showed no significant differences. Chest tube drainage after 24 hours was significantly lower in the Study Group (586 ± 131.8 ml/24 h versus 741 ± 272.5 ml/24 h, p<0.05). Conclusions: Human albumin can passivate the synthetic surfaces of the extracorporeal circuit, which is supported by observations of preserved platelet count and reduced chest tube drainage. Although some statistically significant benefits were observed, the practical benefits of passivating an extracorporeal circuit with human albumin may be minimal.
Association between child and adolescent obesity and parental weight status: A cross-sectional study from rural north China
Authors: Jiang Mo-han , Yang Yang , Guo Xiao-fan , Sun Ying-xian 
Published: June 2013

Objective To investigate the relationship between child and adolescent obesity, and parental weight status. Methods Height and weight were measured in Chinese children and adolescents aged 6–17 years old. Information was collected concerning parental weight and height, and possible covariates, using a questionnaire. The body mass index (BMI) of each study participant and their parents was calculated. On the basis of the BMI, parents were categorized as normal, overweight or obese, and children and adolescents were categorized as normal or obese. Results Of the 5 041 participants included in the study, 6.82% were obese. Child or adolescent obesity was significantly associated with parental obesity. When both parents were obese, there was a 3.62-fold increased risk of obesity compared with those whose parents were of normal weight. Obesity in fathers was associated with a heightened risk of obesity in female children, whereas obesity in mothers was associated with a heightened risk of obesity in male children. Conclusions Parental obesity was a predictor of obesity in children and adolescents. It is therefore of key importance to prevent obesity in children who have one or more obese parents.
Impairment of vascular endothelial function following reperfusion therapy in patients with acute myocardial infarction
Authors: Yang Zhaoying , Li Jinliang , Kong Jian , Wu Suisheng 
Published: June 2013

Objective To investigate vascular endothelial impairment as a result of reperfusion therapy in patients with acute myocardial infarction (AMI). Methods Patients with AMI underwent reperfusion therapy (percutaneous cardiac intervention [PCI] or thrombolytic therapy) or conservative drug therapy. Healthy control subjects were recruited. Endothelial impairment was assessed via endothelial nitric oxide (NO) synthase (eNOS), NO and endothelin-1 (ET-1) levels, 24 h after reperfusion or on enrolment, as appropriate. Results Patients who underwent PCI ( n = 47) or thrombolytic therapy ( n = 45) had significantly lower eNOS and NO levels, and higher ET-1 levels than those who received conservative drug therapy ( n = 46). All patient groups had significantly lower eNOS and NO levels, and higher ET-1 levels, than controls ( n = 45). There was a significant positive correlation between eNOS and NO, as well as significant negative correlations between eNOS/ET-1 and NO/ET-1 in all four groups. Conclusions Patients with AMI who underwent reperfusion therapy displayed low eNOS activity. This may result in impairment of endothelial function via downregulation of NO and upregulation of ET-1.
Prevalence and clinical implications of diverticulosis of the vermiform appendix
Authors: Käser Samuel Andreas , Willi Niels , Maurer Christoph Andreas 
Published: June 2013

Objective The epidemiology and the aetiology of inflammatory diseases of the vermiform appendix remain poorly understood. The prevalence of appendiceal diverticulosis and diverticulitis in patients undergoing appendectomy for suspected acute appendicitis was investigated. Methods A retrospective study was completed on patients who underwent appendectomy for suspected acute appendicitis. Pathology reports of all patients were screened for diverticula of the vermiform appendix. Patients with either diverticulitis of the vermiform appendix or normal appendicitis were compared. Results Out of two sets of consecutive patients ( n = 1073), nine (0.8%) were identified with diverticulosis of the vermiform appendix. Two of these patients had diverticulitis of the vermiform appendix without appendicitis, three had diverticulitis with consecutive localized appendicitis, and four had proper acute appendicitis with a noninflamed diverticulum of the vermiform appendix. One patient had perforated appendicitis. Two patients had an obstructing neuroendocrine carcinoid which may have caused diverticular formation. Conclusions Diverticula of the vermiform appendix are rare. If inflamed, they mimic acute appendicitis and are treated by appendectomy. If not inflamed, and diagnosed intraoperatively, incidental appendectomy is recommended.
High-dose N-acetylcysteine decreases silica-induced lung fibrosis in the rat
Authors: Zhang Hua , Yin Gang , Jiang Hao , Zhang Chunling 
Published: June 2013

Objective To study the potential of high-dose N-acetylcysteine (NAC) to attenuate silica-induced pulmonary fibrosis in the rat. Methods Rats exposed to intratracheal instillation of silica particles were treated with 500 mg/kg NAC orally every day for 7 days, before and up to 28 days after silica administration ( n = 32), or received no treatment following silica exposure ( n = 32); a third group received intratracheal saline ( n = 32). Fibrosis score, and hydroxyproline (HYP) and malondialdehyde (MDA) content, were assessed in lung tissue. Bronchoalveolar lavage fluid (BALF) and serum levels of tumour necrosis factor (TNF)-α, interleukin (IL)-8 and high-sensitivity C-reactive protein (hsCRP) were assessed by enzyme-linked immunosorbent assay. Results Histopathology revealed inflammation and fibrosis in lung tissue from rats exposed to silica, but not in saline controls. The fibrosis score was significantly lower in animals treated with NAC compared with silica-exposed untreated rats. HYP and MDA content were significantly lower at all timepoints, following NAC treatment versus no treatment, in silica-exposed rats. NAC attenuated silica-induced increases in TNF-α, IL-8 and hsCRP in BALF and serum. Conclusions Oral treatment with high-dose NAC during early silica exposure can ameliorate the activity of proinflammatory cytokines, thus attenuating subsequent lung fibrosis. These results suggest that NAC has potential as a treatment for silica-induced lung fibrosis.
Successful therapy for temporomandibular pain alters anterior insula and cerebellar representations of occlusion
Authors: Lickteig Rita , Lotze Martin , Kordass Bernd 
Published: June 2013

Aim Craniomandibular disorders (CMD) are widespread, but we know little about the cerebral representations associated with this pain syndrome and nothing about changes in cerebral representations of occlusion induced by common therapy approaches. Methods In a longitudinal therapy study, we applied functional magnetic resonance imaging (fMRI) in 14 patients with mild CMD during occlusal movements. fMRI, pain scoring, kinematic investigations of occlusal movements, and jaw muscle electromyography (EMG) were measured before and after two weeks of therapy with an individually optimized Michigan splint. Results The patients’ subjective pain ratings decreased, and the symmetry of condylar movements increased over the period of therapy. After therapy, EMG of the jaw muscles demonstrated more relaxed resting conditions and increased activity during maximal occlusion. fMRI during occlusion showed an activation decrease in the right anterior insula and right cerebellum over the course of therapy. Correlation analysis between pain score and fMRI activation decreases identified right anterior insula, left posterior insula and left cerebellar hemisphere. Left cerebellar and right primary motor activation magnitude was negatively associated with symmetry of the condylar movements. Conclusions Our findings highlight the impact of the anterior insula for the internal monitoring and the anticipation of temporomandibular joint (TMJ) pain. In addition, an increase of symmetry of condylar movements after therapy has been associated with a decrease of activation magnitude in primary motor and cerebellar regions.
Prevalence and Incidence of New Meniscus and Cartilage Injuries After a Nonoperative Treatment Algorithm for ACL Tears in Skeletally Immature Children
Authors: Moksnes Håvard , Engebretsen Lars , Risberg May Arna 
Published: June 2013

Background: The increased risk of long-term osteoarthritis from concomitant injuries to the menisci or cartilage after an anterior cruciate ligament (ACL) injury in adults is well established. In skeletally immature children, ACL reconstruction is often recommended to reduce the risk of new intra-articular injuries. However, the prevalence and incidence of new injuries after nonoperative treatment of ACL injuries in children are unknown. Purpose: To prospectively investigate the incidence of new injuries to the menisci and joint cartilage in nonoperatively treated, skeletally immature children with a known ACL injury by use of bilateral 3.0-T MRI. Study Design: Case series; Level of evidence, 4. Methods: Forty skeletally immature children with a ruptured ACL (41 knees) followed a nonoperative treatment algorithm and were evaluated with bilateral 3.0-T MRI on 2 occasions (MRI1 and MRI2). The intra-articular structures were analyzed by 2 independent MRI radiologists. Monitoring of participation in physical activities was accomplished through a monthly online activity survey. Descriptive statistics and frequencies were extracted from the scoring forms and compared using the Fisher exact test. Results: Fourteen girls (35%) and 26 boys (65%) with a mean age of 11.0 ± 1.4 years at the time of injury were included. Time from injury to the final follow-up was 3.8 ± 1.4 years. Eighty-eight percent of the ACL-deficient children confirmed monthly participation in pivoting sports and/or in physical education classes in school. The prevalence of meniscus injuries in the 28 nonreconstructed knees was 28.5% at MRI1 and MRI2, and the incidence of new meniscus and cartilage injuries in the nonreconstructed knees from MRI1 to MRI2 was 3.6%. Thirteen children underwent ACL reconstruction, with a prevalence of meniscus procedures of 46.2%. The incidence of new meniscus injuries from diagnostic MRI to final follow-up was 19.5%. Surgical treatments for meniscus injuries were performed in 8 of the 41 knees. Conclusion: The incidence of new injuries to menisci and joint cartilage was low between MRI1 and MRI2 in the 28 nonreconstructed knees. Thirty-two percent of the knees required ACL reconstruction, and 19.5% required meniscus surgeries during the 3.8 ± 1.4 years of follow-up from injury. Further follow-up is needed to evaluate the long-term knee health in these children.
Licorice treatment prevents oxidative stress, restores cardiac function, and salvages myocardium in rat model of myocardial injury
Authors: Ojha Shreesh Kumar , Sharma Charu , Golechha Mahaveer Jain , Bhatia Jagriti , Kumari Santosh , Arya Dharamvir Singh 
Published: June 2013

The present study examined the effects of licorice on antioxidant defense, functional impairment, histopathology, and ultrastructural alterations in isoproterenol (ISP)-induced myocardial injury in rats. Myocardial necrosis was induced by two subcutaneous injection of ISP (85 mg/kg) at an interval of 24 h. Licorice was administered orally for 30 days in the doses of 100, 200, 400, or 800 mg/kg. ISP-treated rats showed impaired hemodynamics, left ventricular dysfunction, and caused depletion of antioxidants and marker enzymes along with lipid peroxidation from myocardium. ISP also induced histopathological and ultrastructural alterations in myocardium. Pretreatment with licorice prevented the depletion of endogenous antioxidants and myocyte injury marker enzymes, inhibited lipid peroxidation, and showed recovery of hemodynamic and ventricular functions. Licorice treatment also reduced myonecrosis, edema, and infiltration of inflammatory cells and showed preservation of subcellular and ultrastructural components. Our results demonstrate that licorice exerts cardioprotection by reducing oxidative stress, augmenting endogenous antioxidants, and restoring functional parameters as well as maintaining structural integrity.
Hydroxyapatite scaffold pore architecture effects in large bone defects in vivo
Authors: Guda Teja , Walker John A , Singleton Brian , Hernandez Jesus , Oh Daniel S , Appleford Mark R , Ong Joo L , Wenke Joseph C 
Published: June 2013

To examine the effect of scaffold pore size on bone regeneration within hydroxyapatite scaffolds in large segmental defects, this study evaluated two porous interconnected architectures having similar porosity and strut thickness but different pore sizes. Using a 10 mm segmental rabbit radius defect model, a bilayer scaffold architecture mimicking the cortical-cancellous organization of bone (pore size 200 µm outer layer, 450 µm inner layer) was compared to a purely trabecular-like architecture (pore size 340 µm) and an untreated defect. Bone regeneration was measured using micro-computed tomography and histology after four and eight weeks of in vivo implantation, and the mechanical strength of the defect site after eight weeks’ implantation was assessed using flexural testing. Although both bilayer and trabecular architectures promoted bone growth, the trabecular scaffolds were observed to have more uniform new bone distribution within the scaffold interior at four weeks and greater bone regeneration overall after eight weeks’ implantation (149 ± 9 mm3 compared to 121 ± 8 mm3 in the bilayer and 66 ± 14 mm3 in the defect). Additionally, the trabecular scaffolds were observed to exhibit significantly greater flexural strength (124% increase) and toughness (388% increase) when compared to the empty defects after eight weeks’ implantation. It was concluded from this study that a larger uniform pore size led to greater functional bone regeneration over a longer implantation period for large segmental defects.
Near-Anatomic Allograft Tenodesis of Chronic Lateral Ankle Instability
Authors: Miller Adam G. , Raikin Steven M. , Ahmad Jamal 
Published: June 2013

Background: Current operative treatment options for chronic lateral ankle instability include anatomic repairs utilizing existing local tissue and nonanatomic reconstructions sacrificing the peroneus brevis tendon to mechanically stabilize the ankle. Recent studies have modified these techniques to create an anatomic reconstruction utilizing allograft tendons. The purpose of this study was to retrospectively examine the clinical outcomes of a near-anatomic ligament reconstruction utilizing an allograft tendon for recurrent or complex lateral ankle instability. Methods: Twenty-eight patients underwent a near-anatomic allograft lateral ankle ligament reconstruction with a semitendinosis allograft for severe or recurrent lateral ankle ligamentous instability, and all of them were available for follow-up at an average 32 months. Twelve patients had previously undergone lateral ankle ligament stabilizing surgery, 4 had Ehlers Danlos syndrome with poor local tissue, 5 had greater than 30 degrees of varus angulation of talar tilt, while 12 had associated hindfoot varus requiring concomitant reconstruction. Patients were assessed pre- and postoperatively for Visual Analog Scores (VAS) for pain, Foot and Ankle Ability Measures (FAAM), patient satisfaction, radiographic correction, and complications. Results: Median VAS of pain decreased from 8 before surgery to 1 after surgery ( P < .001). Median FAAM score increased from 41.7 to 95.2 after surgery ( P < .001). Radiographic comparison demonstrated correction of preoperative varus malalignment in all but 1 patient. No patients developed subsequent subtalar arthritis or pain. Three patients had mild persistent instability, all of which was managed nonoperatively. One of the patients with persistent instability also developed chronic regional pain syndrome following surgery. At final follow-up, 25 of 28 patients rated their satisfaction as good or excellent and 3 as fair. No patients required revision surgery. Conclusion: Lateral ligament reconstruction utilizing a near-anatomically placed and tensioned allograft tendon was a viable option in treating recurrent and complex lateral instability. Not sacrificing the peroneal tendons avoided loss of eversion strength. Near-anatomic placement of the allograft provided good ankle stability without sacrificing subtalar motion or predisposition to subtalar arthritis in short-term follow-up. Level of Evidence: Level IV, retrospective case series.
Video telehealth for weight maintenance of African-American women
Authors: Gerber Ben S , Schiffer Linda , Brown Allison A , Berbaum Michael L , Rimmer James H , Braunschweig Carol L , Fitzgibbon Marian L 
Published: June 2013

Summary We evaluated the effect of home telehealth on weight maintenance after a group-based weight loss programme. The home telehealth intervention comprised telephone counselling and home Internet-enabled digital video recorders (DVRs) with three channels of video programmes. The video content provided reinforcement and support to promote problem solving, prevent relapse and sustain motivation. Eighty-eight obese or overweight African-American women were randomized to receive monthly telephone counselling (control) or the home telehealth intervention. The weight change during maintenance was not significant in either group (0.6 kg in the intervention group, 0.0 kg in the control group), and there was no significant difference between them. Changes in diet, physical activity, social support and self-efficacy during the maintenance period did not differ significantly between groups. DVR use was low: during the intervention, the number of valid DVR viewings ranged from zero to 42 per person. DVR use was positively associated with previous attendance at the weight loss classes. Home video-based telehealth is a new method of delivering a weight loss maintenance intervention to African-American women. It had no effect on weight maintenance in the present study.