bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development, Experience, and Expression of Meaning in Genetic Counselors’ Lives: an Exploratory Analysis
Authors: Wells David M. , McCarthy Veach Patricia , Martyr Meredith A. , LeRoy Bonnie S. 
Published: October 2015

AbstractGenetic counselors routinely engage with patients and families who grapple with questions of meaning while making decisions about genetic risk. Research and theory demonstrate genetic counselors gain important personal insights through their work and develop professionally from self‐reflective practice regarding their beliefs and values. Data are lacking, however, about the nature of the meaning genetic counselors bring to their profession and how they directly experience and/or navigate issues of meaning within clinical practice over time. Accordingly, a national sample (N = 298) of practicing genetic counselors completed a brief survey assessing their demographic characteristics and willingness to participate in a semi‐structured telephone interview exploring their views on meaning as they relate to their clinical work and professional development. Sixty‐eight individuals of varied experience levels were interviewed about: 1) how they define a meaningful life for themselves; 2) lifetime sources of influence on their sense of meaning; 3) how they experience meaning within both personal and professional contexts; 4) work‐related contexts that reaffirm and challenge their sense of meaning; and 5) how their sense of meaning has changed over time. Twenty‐five interviews were analyzed using Consensual Qualitative Research methods, at which point, data saturation was reached. Five themes, 32 domains, and 29 categories were extracted. Common findings include: importance of satisfying relationships; helping others; personal fulfillment; personal and patient experiences of illness and loss; religious and/or spiritual foundations; value conflicts; competing obligations; challenges to meaning; development of empathy; resiliency; and increased humility. Results suggest the importance of professional venues for discussions of meaning (e.g., genetic counseling program curricula, continuing education, and peer supervision/consultation). Additional findings, practice implications, and research recommendations are presented.
Prospective observational study of near‐miss obstetric events at two tertiary hospitals in Mumbai, Maharashtra, India
Authors: Kulkarni Ragini , Chauhan Sanjay , Daver Rekha , Nandanwar Yogeshwar , Patil Anushree , Bhosale Archana 
Published: October 2015

AbstractObjectiveTo review the incidence and patterns of near‐miss obstetric events (defined as “A woman who nearly died but survived a complication that occurred during pregnancy, childbirth or within 42 days of termination of pregnancy”), as well as studying the classification criteria for near‐miss events.MethodsA prospective observational study was conducted in two tertiary hospitals in Mumbai. Women with near‐miss obstetric events were interviewed during the period September 2012–August 2013.ResultsThere were 884 near‐miss events among 877 women, with seven patients readmitted. Clinical‐criteria for near‐miss events, accounting for 701 (79.3%) cases, were the commonest among the three classifications of near‐miss events. Among the cases observed, hypertensive disorders of pregnancy (472 [53.4%]), severe anemia (185 [20.9%]), and postpartum hemorrhage 68 [7.7%]) were the most common causes of near‐miss events. The most common problem encountered by patients prior to hospital admission for the near‐miss cases was the unavailability of treatment at lower‐level health facilities, affecting 598 (68.2%) of the 877 study participants.ConclusionHypertensive disorders of pregnancy, postpartum hemorrhage, and severe anemia remain important determinants in maternal morbidity. Facilities and training at first‐referral units should be improved so that they can respond better to basic obstetric emergencies such as sepsis, hemorrhage, and shock.
Epidemiology of Search and Rescue in Baxter State Park: Dangers of Descent and Fatigue
Authors: Welter Chris R. , Sholl J. Matthew , Strout Tania D. , Woodard Ben 
Published: October 2015

Objective The purpose of this study was to determine the epidemiology of injury in Baxter State Park, Maine, and to better tailor search and rescue (SAR) resources, personnel, and training to acute needs in the park. Methods We conducted a retrospective review of all SAR incident reports in Baxter State Park from July 1992 through June 2014. For each event, demographics, location, time, activity before the incident, incident details, and evacuation means were recorded and analyzed. Results In all, 754 incidents of SAR or medical need were identified. Mean age was 38.9 years; mean age for subjects with fatigue as the primary complaint was 48.7 years. A majority (60.5%) of victims were male. Nineteen fatalities occurred during the study. Traumatic injuries precipitated 51% of SAR incidents, and an additional 30% were initiated for late or lost parties. Slips or falls while hiking were the most common causes of injury (67%), with the lower extremity being the most common injury site (31%). When applicable, 84.4% of acute need occurred while descending, as opposed to ascending, a mountain. Fatigue was the most commonly reported medical emergency, causative in 66% of medical SAR events. Conclusions Fatigue is a major factor in SAR events, both as a discreet cause and as a contributor to other injuries. Search and rescue need is more likely to occur during mountain descent, and lower extremity injuries are the most common etiology. Efforts should be focused on training rescuers in lower extremity and fatigue treatment, and more rescuers should be available when many are descending.
Control of Pim2 kinase stability and expression in transformed human haematopoietic cells
Authors: Adam Kévin , Lambert Mireille , Lestang Elsa , Champenois Gabriel , Dusanter-Fourt Isabelle , Tamburini Jérôme , Bouscary Didier , Lacombe Catherine , Zermati Yael , Mayeux Patrick 
Published: October 2015

The oncogenic Pim2 kinase is overexpressed in several haematological malignancies, such as multiple myeloma and acute myeloid leukaemia (AML), and constitutes a strong therapeutic target candidate. Like other Pim kinases, Pim2 is constitutively active and is believed to be essentially regulated through its accumulation. We show that in leukaemic cells, the three Pim2 isoforms have dramatically short half-lives although the longer isoform is significantly more stable than the shorter isoforms. All isoforms present a cytoplasmic localization and their degradation was neither modified by broad-spectrum kinase or phosphatase inhibitors such as staurosporine or okadaic acid nor by specific inhibition of several intracellular signalling pathways including Erk, Akt and mTORC1. Pim2 degradation was inhibited by proteasome inhibitors but Pim2 ubiquitination was not detected even by blocking both proteasome activity and protein de-ubiquitinases (DUBs). Moreover, Pyr41, an ubiquitin-activating enzyme (E1) inhibitor, did not stabilize Pim2, strongly suggesting that Pim2 was degraded by the proteasome without ubiquitination. In agreement, we observed that purified 20S proteasome particles could degrade Pim2 molecule in vitro. Pim2 mRNA accumulation in UT7 cells was controlled by erythropoietin (Epo) through STAT5 transcription factors. In contrast, the translation of Pim2 mRNA was not regulated by mTORC1. Overall, our results suggest that Pim2 is only controlled by its mRNA accumulation level. Catalytically active Pim2 accumulated in proteasome inhibitor-treated myeloma cells. We show that Pim2 inhibitors and proteasome inhibitors, such as bortezomib, have additive effects to inhibit the growth of myeloma cells, suggesting that Pim2 could be an interesting target for the treatment of multiple myeloma.
Optimizing Vowel Formant Measurements in Four Acoustic Analysis Systems for Diverse Speaker Groups
Authors: Derdemezis Ekaterini , Vorperian Houri K. , Kent Ray D. , Fourakis Marios , Reinicke Emily L. , Bolt Daniel M. 
Published: October 2015

Purpose
This study systematically assessed the effects of select linear predictive coding (LPC) analysis parameter manipulations on vowel formant measurements for diverse speaker groups using 4 trademarked Speech Acoustic Analysis Software Packages (SAASPs): CSL, Praat, TF32, and WaveSurfer.

Method
Productions of 4 words containing the corner vowels were recorded from 4 speaker groups with typical development (male and female adults and male and female children) and 4 speaker groups with Down syndrome (male and female adults and male and female children). Formant frequencies were determined from manual measurements using a consensus analysis procedure to establish formant reference values, and from the 4 SAASPs (using both the default analysis parameters and with adjustments or manipulations to select parameters). Smaller differences between values obtained from the SAASPs and the consensus analysis implied more optimal analysis parameter settings.

Results
Manipulations of default analysis parameters in CSL, Praat, and TF32 yielded more accurate formant measurements, though the benefit was not uniform across speaker groups and formants. In WaveSurfer, manipulations did not improve formant measurements.

Conclusions
The effects of analysis parameter manipulations on accuracy of formant-frequency measurements varied by SAASP, speaker group, and formant. The information from this study helps to guide clinical and research applications of SAASPs.
Nursing Diagnosis of “Spiritual Distress” in Women With Breast Cancer
Authors: Caldeira Sílvia , Timmins Fiona , de Carvalho Emília C. , Vieira Margarida 
Published: October 2015

Background:
Spirituality and spiritual needs of cancer patients are frequently mentioned in the nursing literature, but the most significant defining characteristics of spiritual distress in the context of clinical reasoning and nursing diagnosis are rarely explored. Understanding of these is important for effective spiritual intervention.

Objective:
The aim of this study was to identify the prevalence and the defining characteristics of the nursing diagnosis “spiritual distress,” as classified according to NANDA International, among women with breast cancer.

Methods:
This was a quantitative and cross-sectional study, comprising the third phase of a larger study investigating the clinical validation of spiritual distress in cancer patients undergoing chemotherapy. Fehring’s clinical diagnostic validation model was used to identify the prevalence and the major defining characteristics of the diagnosis. A convenience sample was used, and data were collected by structured interview.

Results:
A total of 70 women participated; most were married (62.9%) and had a mean age of 54 years, and 55.7% reported having at least 1 person depending on them. The average length of time since the cancer diagnosis was 30.9 months. Twenty-seven participants were experiencing spiritual distress (38.6%). Eleven defining characteristics were classified as major.

Conclusions:
The prevalence of spiritual distress and the major defining characteristics give clinical evidence about the nurse’s role in providing spiritual care. The results are useful for the improved use of the NANDA International diagnoses within this domain.

Implications for Practice:
The findings highlight the importance of assessing the defining characteristics of the diagnosis as an objective strategy to improve clinical reasoning related to spirituality and to facilitate more effective interventions.
Single molecule targeted sequencing for cancer gene mutation detection
Authors: Gao Yan , Deng Liwei , Yan Qin , Gao Yongqian , Wu Zengding , Cai Jinsen , Ji Daorui , Li Gailing , Wu Ping , Jin Huan , Zhao Luyang , Liu Song , Deem Michael W. , He Jiankui 
Published: October 2015

AbstractWith the rapid decline cost of sequencing, it is now clinically affordable to examine multiple genes in a single disease-targeted test using next generation sequencing. Current targeted sequencing methods require a separate step of targeted capture enrichment during sample preparation before sequencing, and the library preparation process is labor intensive and time consuming. Here, we introduced an amplification-free Single Molecule Targeted Sequencing (SMTS) technology, which combined targeted capture and sequencing in one step. We demonstrated that this technology can detect low-frequency mutations of cancer genes. SMTS has several advantages, namely that it requires little sample preparation and avoids biases and errors introduced by PCR reaction. SMTS can be applied in cancer gene mutation detection, inherited condition screening and noninvasive prenatal diagnosis.
SpectralTDF: transition densities of diffusion processes with time-varying selection parameters, mutation rates, and effective population sizes
Authors: Steinrücken Matthias , Jewett Ethan M. , Song Yun S. 
Published: October 2015

ABSTRACTIn the Wright-Fisher diffusion, the transition density function (TDF) describes the time-evolution of the population-wide frequency of an allele. This function has several practical applications in population genetics, and computing it for biologically realistic scenarios with selection and demography is an important problem. We develop an efficient method for finding a spectral representation of the TDF for a general model where the effective population size, selection coefficients, and mutation parameters vary over time in a piecewise constant manner. The method, called spectralTDF, is available athttps://sourceforge.net/projects/spectraltdf/.
The relationship between humorous leadership and innovative behavior
Authors: Pundt Alexander 
Published: October 2015

Purpose– The purpose of this paper is to investigate the relationship between humorous leadership and innovative behavior and the moderator effects of creative requirement and perceived innovation climate, beyond transformational leadership, and leader-member exchange (LMX).Design/methodology/approach– Questionnaire data were collected from 150 employees of various organizations in Germany.Findings– Employees whose leader used humor more frequently reported to be more innovative, when the employees perceived their tasks to require creativity and innovation. Perceived innovation climate did not moderate the relationship.Research limitations/implications– Different humor styles rather than just positive humor should be investigated in the future. Future research should incorporate multi-level designs and objective data on innovative behavior.Practical implications– Humorous leadership is an important element of innovation-relevant leadership behavior. Its use may be integrated in broader leadership development approaches.Originality/value– The study contributes to knowledge on humorous leadership and its relationship to organizational behavior. It enhances theoretical developments by considering the employees’ task and perceived innovation climate as moderator variables. It helps establish humor as a leadership tool beyond constructs such as LMX or transformational leadership.
Conflicting personal goals: a risk to occupational well-being?
Authors: Hyvönen Katriina , Rantanen Johanna , Huhtala Mari , Wiese Bettina S. , Tolvanen Asko , Feldt Taru 
Published: October 2015

Purpose
– The purpose of this paper is to investigate the moderating role of goal conflict in the relationship between the contents of managers’ personal work goals and occupational well-being (burnout and work engagement). Eight goal categories (organization, competence, well-being, career-ending, progression, prestige, job change, and employment contract) described the contents of goals. Goal conflict reflected the degree to which a personal work goal was perceived to interfere with other life domains.

Design/methodology/approach
– The data were drawn from a study directed to Finnish managers in 2009 (n=806). General linear models were conducted to investigate the associations between goal content categories and occupational well-being and to test whether goal conflict moderates the relationship between goal content categories and occupational well-being.

Findings
– Career-ending goals related to significantly higher burnout than progression goals. Participants with organization, competence, or progression goals reported the highest goal conflict, whereas participants with well-being, career-ending, or job change goals reported lower goal conflict. Goal conflict was found to have a moderating role: in a high-goal conflict situation, participants with organizational, competence, and progression goals reported lower occupational well-being, whereas participants with job change goals reported higher occupational well-being.

Originality/value
– The research highlights that both the contents and appraisals (e.g. goal conflict) of personal work goals should be taken into account when investigating the relationship between personal goals and well-being at work.
Communicating virtually in a global organization
Authors: Brotheridge Céleste M. , Neufeld Derrick J. , Dyck Bruno 
Published: October 2015

Purpose– The purpose of this paper is to consider the extent to which changes in communication media are associated with changes in the nature of manager-expatriate employee communications. Using an affordance lens, the authors explore how hierarchical level and communication medium interact to influence status dynamics manifested in communication attributes.Design/methodology/approach– The hypothesis was tested with a 2 (hierarchical level)×3 (communication media) multivariate analysis of covariance (experience level) in a sample of 1,193 messages that were transmitted between managers and field employees in a global organization over a ten year period.Findings– The authors found significant interaction effects between communication media and hierarchical level on communication attributes such that changes in communication media intensified status differences between managers and their employees.Research limitations/implications– Communications media may be appropriated differently depending on one’s hierarchical level.Practical implications– Managers should adopt new communication media more consciously given their potential influence of how people communicate.Originality/value– Unlike many computer-mediated communications (CMC) effects studies that compare face-to-face communications with CMC or employ self-report questionnaires or laboratory designs with student samples, this study examines a complete set of manager-employee communications over an extended period of time.
Sharing my knowledge? An interactional perspective
Authors: Lee Soojin , Yoo Yongsu , Yun Seokhwa 
Published: October 2015

Purpose
– The purpose of this paper is to identify factors that facilitate individual knowledge sharing. Specifically, the authors investigated the roles of coworker support and individual characteristics, i.e., exchange ideology and learning orientation on knowledge sharing.

Design/methodology/approach
– Data were collected from questionnaires distributed to employees and their direct supervisors in two companies in South Korea. Hierarchical regression analyses and simple slope test were performed to test the hypotheses.

Findings
– Coworker support and learning orientation is positively but exchange ideology is negatively related to knowledge sharing. Furthermore, when coworker support is low, knowledge sharing is mainly dependent on each individual’s characteristics. However, when coworker support is high, employees showed high level of knowledge sharing irrespective of their individual characteristics.

Research limitations/implications
– This study suggested that the support from coworker as well as individuals’ characteristics plays an important role in determining their knowledge sharing behaviors. Moreover, the authors found the significant interaction effects of coworker support and individual characteristics on knowledge sharing, drawing on insights from trait activation theory.

Practical implications
– For organizations to encourage individual knowledge sharing behaviors, they may need to maintain the work environment that encourages the peer workers to support each other.

Originality/value
– Although many actions have been adopted to foster knowledge management in organizations, employees may still be reluctant to share their knowledge. This paper highlights not only the main effects of coworker support and individual differences but also the interaction effect between them in facilitating knowledge sharing.
Organizational identification, work engagement, and job satisfaction
Authors: Karanika-Murray Maria , Duncan Nikita , Pontes Halley M. , Griffiths Mark D. 
Published: October 2015

Purpose– Organizational identification refers to a person’s sense of belonging within the organization in which they work. Despite the importance of organizational identification for work-related attitudes and organizational behavior, little research has directly examined the mechanisms that may link these. The purpose of this paper is to provide an understanding of how organizational identification relates to job satisfaction.Design/methodology/approach– Adopting a social identity perspective, the authors present and test two models that describe work engagement and its constituent dimensions (vigor, dedication, absorption) as mediating the relationship between organizational identification and job satisfaction.Findings– Bootstrapped mediation analyses provided support for full mediation whereby there is an indirect (via work engagement) and positive effect of organizational identification on job satisfaction. Analyses also provided support for the mediating effects of the three dimensions of work engagement, vigor, dedication, and absorption, in this relationship.Practical implications– Although cross-sectional, this study provides a needed first step toward an understanding of the important role of organizational identification for job satisfaction and the mediating role of work engagement in this relationship.Originality/value– The results provide valuable insights into the effects of organizational identification and address some of the gaps in understanding social identity as the context for work behaviors. Theoretical and practical implications for strengthening employee engagement and enhancing organizational identification are discussed.
Mesoporous Silica‐Based Supports for the Controlled and Targeted Release of Bioactive Molecules in the Gastrointestinal Tract
Authors: Pérez‐Esteve Édgar , Ruiz‐Rico María , Martínez‐Máñez Ramón , Barat José Manuel 
Published: October 2015

AbstractMesoporous silica particles (MSPs) have attracted increasing interest as supports in the design of controlled delivery materials. Besides their excellent properties as loading supports (that is, large surface area and pore volume), the modification of their external surface with molecular/supramolecular ensembles allows the design of gated MSPs. Delivery systems based on gated MSPs show “zero delivery” until an adequate stimulus is present and triggers gate opening and the cargo is released. Encapsulation of bioactive molecules in gated MSPs may improve biological stability, facilitate component handling, mask unpleasant sensorial properties, and modulate the bioaccessibility of target molecules along the gastrointestinal tract. These properties make gated MSPs excellent candidates for encapsulating bioactive molecules and their subsequent utilization in the formulation of functional foods. This text highlights the most significant endogenous triggering stimuli that might be applied to design these site‐specific delivery systems, as well as the strategies to develop them. Given the novelty of using MSPs in the food sector, the benefits and current potential limitations of employing MSPs in human food have been identified and discussed.