bluuebunny/crossref_metadata_2025_split huggingface dataset:
Our research path toward the restoration of natural sensations in hand prostheses
Authors: Micera Silvestro , Shokur Solaiman 
Published: July 2024

AbstractThe human hand, with its intricate sensory capabilities, plays a pivotal role in our daily interactions with the world. This remarkable organ possesses a wide range of natural sensors that enrich our experiences, enabling us to perceive touch, position, and temperature. These natural sensors work in concert to provide us with a rich sensory experience, enabling us to distinguish between various textures, gauge the force of our grip, determine the position of our fingers without needing to see them, perceive the temperature of objects we come into contact with or detect if a cloth is wet or dry. This complex sensory system is fundamental to our ability to manipulate objects, explore our surroundings, and interact with the world and people around us. In this article, we summarize the research performed in our laboratories over the years and our findings to restore both touch, position, and temperature modalities. The combination of intraneural stimulation, sensory substitution, and wearable technology opens new possibilities for enhancing sensory feedback in prosthetic hands, promising improved functionality and a closer approximation to natural sensory experiences for individuals with limb differences.
Fellow eye data for intraocular lens calculation in eyes undergoing combined phacovitrectomy
Authors: Kaiser Klemens Paul , Bucur Julian , Jandewerth Tyll , Kohnen Thomas , Lwowski Christoph 
Published: July 2024

AbstractPurposeTo evaluate whether the intraocular lens (IOL) calculation of the fellow eye (FE) can be used in eyes undergoing combined phacovitrectomy.MethodsIn this retrospective, consecutive case series, we enrolled patients who underwent combined phacovitrectomy with silicone oil removal and IOL implantation at the Goethe‐University. Preoperative examinations included biometry (IOLMaster 700; Carl Zeiss). We used the IOL calculation of the FE (FE group) to calculate the prediction error compared with the IOL calculation using only the axial length (AL) of the FE (AL‐FE group), as well as using the AL of the operated eye (OE group) in addition to the measurable biometric parameters. IOL calculation was performed using the Barrett Universal II formula. We compared the mean (MAE) and median absolute prediction error (MedAE) with each other. Furthermore, the number of eyes with ±0.50, ±1.00 and ±2.00 dioptres (D) deviation from the target refraction was compared.ResultsIn total, 79 eyes of 79 patients were included. MedAE was lowest in the OE group (0.41 D), followed by FE group (1.00 D) and AL‐FE group (1.02 D). Comparison between the AL‐FE and FE groups showed no statistically significant difference (p = 0.712). Comparing eyes within ±0.50 D of the target refraction, the OE group (63.3%) performed best, followed by the AL‐FE group (27.8%) and the FE group (26.6%).ConclusionOur results indicate no clinically relevant difference between using the IOL calculation of the FE versus using only the AL of the FE in addition to the measurable parameters for the IOL calculation. A two‐step procedure should always be strived for.
The long‐term impact of household debts on household consumption
Authors: Xie Zhuyun , Xie Yuzhe , Liu Yue , Xu Guoliang , Xu Biao 
Published: July 2024

AbstractUsing panel data from 2012 to 2018, this article investigates the long‐term impact of household debt on household consumption, which is very important to the sustainable development of economy. The result shows that total household debt has a significant crowding‐out impact on long‐term household consumption, whereas nonhousing debt has no significant effect on it. In addition, we also find that the debt of high‐asset families has a weaker impact on long‐term household consumption; the debt of rural families, however, has a greater crowding‐out effect, which means that increasing rural families' leverage will have a greater negative impact on household consumption. Finally, household debt's negative effect on long‐term consumption was not found in older families, whereas it is found at significant level in middle‐aged families. The above results have important implications for China's policy to stimulate consumption and promote sustainable economic development.
Comparison of holmium:yttrium‐aluminium‐garnet (YAG), thulium fiber laser, and pulsed thulium:YAG lasers on soft tissue: an ex vivo study
Authors: Kutchukian Stessy , Chicaud Marie , Berthe Laurent , Coste Frédéric , Lapouge Pierre , Alshehhi Hussa , Buob David , Traxer Olivier , Panthier Frédéric , Doizi Steeve 
Published: July 2024

ObjectivesTo assess laser–tissue interactions through ablation, coagulation, and carbonisation characteristics in a non‐perfused porcine kidney model between three pulsed lasers: holmium (Ho): yttrium‐aluminium‐garnet (YAG), thulium fiber laser (TFL), and pulsed thulium (p‐Tm):YAG.Materials and MethodsA 150‐W Ho:YAG, a 60‐W TFL, and a 100‐W p‐Tm:YAG lasers were compared. The laser settings that can be set identically between the three lasers and be clinically relevant for prostate laser enucleation were identified and used on fresh, unfrozen porcine kidneys. Laser incisions were performed using stripped laser fibers of 365 and 550 μm, set at distances of 0 and 1 mm from the tissue surface at a constant speed of 2 mm/s. Histological analysis evaluated shape, depth, width of the incision, axial coagulation depth, and presence of carbonisation.ResultsIncision depths, widths, and coagulation zones were greater with Ho:YAG and p‐Tm:YAG lasers than TFL. Although no carbonisation was found with the Ho:YAG and p‐Tm:YAG lasers, it was common with TFL, especially at high frequencies. The shapes of the incisions and coagulation zones were more regular and homogeneous with the p‐Tm:YAG laser and TFL than with Ho:YAG laser. Regardless of the laser used, short pulse durations resulted in deeper incisions than long pulse durations. Concerning the distance, we found that to be effective, TFL had to be used in contact with the tissue. Finally, 365‐μm fibers resulted in deeper incisions, while 550‐μm fibers led to wider incisions and larger coagulation zones.ConclusionHistological analysis revealed greater tissue penetration with the p‐Tm:YAG laser compared to the TFL, while remaining less than with Ho:YAG. Its coagulation properties seem interesting insofar as it provides homogeneous coagulation without carbonisation, while incisions remained uniform without tissue laceration. Thus, the p‐Tm:YAG laser appears to be an effective alternative to Ho:YAG and TFL lasers in prostate surgery.
Repurposing cyclovirobuxine D as a novel inhibitor of colorectal cancer progression via modulating the CCT3/YAP axis
Authors: Liu Yiman , Chen Lu , Wang Jinghui , Bao Xiaomei , Huang Jiayan , Qiu Yuling , Wang Tao , Yu Haiyang 
Published: July 2024

Background and PurposeColorectal cancer (CRC) ranks second in mortality worldwide and requires effective and affordable remedies. Cyclovirobuxine D (CVB‐D) is the main effective component of Huangyangning tablet, an approved traditional patent medicine, which is mainly used for cardiovascular treatment. As a multibioactive natural compound, CVB‐D possesses underlying anticancer activities.Experimental ApproachCell viability and clone‐forming ability were determined in human CRC lines. Western blot, immunofluorescence assay, transmission electron microscopy and senescence‐associated β‐galactosidase (SA‐β‐Gal) staining were utilized to investigate cell autophagy and senescence. The molecular mechanisms were explored by virtual prediction and experimental validation. Patient‐derived xenograft (PDX), dextran sulfate sodium salt (DSS), and azomethane (AOM)/DSS mouse models were employed for in vivo studies.Key ResultsCVB‐D inhibited the growth and development of advanced CRC cells / mice by inducing autophagic and senescent activities through the chaperonin containing TCP1 subunit 3 (CCT3)/yes‐associated protein (YAP) axis. CVB‐D acted as a promising inhibitor of CCT3 by interacting with its ATP site. In PDX tumours, CVB‐D showed potential therapeutic effects by targeting CCT3. Treatment with CVB‐D alleviated the mouse model of colitis induced by DSS and attenuated AOM/DSS‐induced formation of adenomatous polyps by its action on CCT3.Conclusions and ImplicationsOur study has provided a scientific basis for the suggestion that CVB‐D may be recognized as a prospective drug candidate for the therapy of CRC in patients.
Memory inflation: Beyond the acute phase of viral infection
Authors: Li Yanfei , Xiao Jie , Li Chen , Yang Mu 
Published: July 2024

AbstractMemory inflation is confirmed as the most commonly dysregulation of host immunity with antigen‐independent manner in mammals after viral infection. By generating large numbers of effector/memory and terminal differentiated effector memory CD8+ T cells with diminished naïve subsets, memory inflation is believed to play critical roles in connecting the viral infection and the onset of multiple diseases. Here, we reviewed the current understanding of memory inflated CD8+ T cells in their distinct phenotypic features that different from exhausted subsets; the intrinsic and extrinsic roles in regulating the formation of memory inflation; and the key proteins in maintaining the expansion and proliferation of inflationary populations. More importantly, based on the evidences from both clinic and animal models, we summarized the potential mechanisms of memory inflation to trigger autoimmune neuropathies, such as Guillain‐Barré syndrome and multiple sclerosis; the correlations of memory inflation between tumorigenesis and resistance of tumour immunotherapies; as well as the effects of memory inflation to facilitate vascular disease progression. To sum up, better understanding of memory inflation could provide us an opportunity to beyond the acute phase of viral infection, and shed a light on the long‐term influences of CD8+ T cell heterogeneity in dampen host immune homeostasis.
Economic and financial integration, capital controls, and risk sharing
Authors: Donadelli Michael , Gufler Ivan 
Published: July 2024

AbstractWe analyse economic (EI) and financial (FI) integration, and their effects on international consumption risk sharing (RS) across 40 countries, including 21 developed (DEV) and 19 emerging (EM) markets, from 1995 to 2019. Utilizing the metric for EI and FI of Akbari et al. (2020, Journal of Financial and Quantitative Analysis, 55, 2270–303), and various RS proxies, we find that increasing EI reduces RS in EM, while FI enhances it. Conversely, there is no evidence that EI or FI influences RS in DEV, contradicting theoretical predictions from international business cycle models. These results remain robust when controlling for trade and financial openness and capital flow restrictions. Additionally, we investigate the direct influence of capital controls on market integration. Relaxing equity inflow controls significantly enhances market integration, specifically boosting EI in DEV, and FI in EM. In contrast, equity outflow restrictions and controls on other asset categories do not significantly impact market integration. Our findings challenge the idea that simply removing legal restrictions on international capital flows is sufficient or necessary to achieve greater market integration and improved RS. This underscores the perspective that adjustments in capital controls alone may not ensure macro‐financial stability.
Response of rubber tree clones to black crust
Authors: Antonio Gabriel Leonardi , Mattochek Túlio Augusto , Perfeito Dhonata Marcos , Junior Erivaldo José Scaloppi , Fischer Ivan Herman , Furtado Edson Luiz , Firmino Ana Carolina 
Published: July 2024

AbstractThe occurrence of black crust, a disease previously considered secondary, has become a cause for concern due to early leaf fall in rubber trees (Hevea brasiliensis). This study aimed to identify sources of resistance to black crust in 21 clones of rubber trees in a clonal garden. To achieve this, the disease severity was evaluated through eight assessments conducted over a 2‐year period. In each evaluation, 15 leaflets from three different parts of the plant (bottom, middle third and crown) were randomly collected, resulting in a total of 45 leaflets per plant. These leaflets were then taken to the laboratory, and the software Leaf Doctor was used to measure the percentage of leaf area exhibiting symptoms of black crust. The results were analysed using the Scott‐Knott test at a 5% probability level. The clones with the highest infected leaf area observed during the evaluations were IAC300, IAC418, IAC503, PB311 and RRIM600. Clone IAC511 did not show any symptoms of the disease in any of the evaluations. Clones IAC301, IAC411, IAC501, IAC507 and IRCA111 exhibited low percentages of affected leaf areas. Additionally, this study revealed the progression of the disease over the evaluation period. The infection initially starts on the youngest leaves (crown) in March and subsequently intensifies in the middle third of the plant, corresponding to the youngest leaf previously infected in the crown. Furthermore, environmental data collected in the experimental area over the 2‐year evaluation period indicated that the disease manifests with greater severity when the average temperatures fall below 25°C after periods of heavy rainfall, followed by dry periods with low relative humidity. The data presented in this study significantly contribute to the management of this disease in the field by identifying clones where the disease manifests with lower severity.
An open‐label, first‐in‐human, single agent, dose escalation study for the evaluation of safety and efficacy of SAR442085 in patients with relapsed or refractory multiple myeloma
Authors: Kapoor Prashant , Nathwani Nitya , Jelinek Tomas , Pour Ludek , Perrot Aurore , Dimopoulos Meletios‐Athanasios , Huang Shang‐Yi , Spicka Ivan , Chhabra Saurabh , Lichtman Eben , Mateos Maria‐Victoria , Kanagavel Dheepak , Zhao Liang , Guillemin‐Paveau Helene , Macé Sandrine , van de Velde Helgi , Richardson Paul G. 
Published: July 2024

AbstractObjectivesCluster of differentiation 38 (CD38) is a key target on multiple myeloma (MM) cells. This multi‐centre, Phase 1, single‐agent study (NCT04000282) investigated SAR442085, a novel fragment crystallisable (Fc)‐modified anti‐CD38 monoclonal antibody (mAb), with enhanced affinity towards Fc‐gamma receptor on effector cells in patients with relapsed and/or refractory (RR) MM.MethodsThis study comprised two parts: Part‐A (dose‐escalation involving anti‐CD38 mAb pre‐treated and naïve patients) and Part‐B (dose expansion). Primary endpoints were maximum tolerated dose and recommended Phase 2 dose (RP2D).ResultsThirty‐seven heavily pre‐treated patients were treated in Part A. Part‐B (dose‐expansion) was not studied. Seven dose‐limiting toxicities were reported at DL3, DL5, DL6, and DL7. RP2D was determined to be 5–7·5 mg/kg. Most common treatment‐emergent adverse events were infusion‐related reactions in 70·3% (26/37) patients. Grade ≥3 thrombocytopenia was reported in 48·6% (18/37). Overall response rate was 70% in anti‐CD38 mAb naïve and 4% in anti‐CD38 pre‐treated patients, with a median progression‐free survival of 7·62 (95%CI: 2·858; not calculable) months and 2·79 (95%CI: 1·150; 4·172) months and, respectively.ConclusionsThe efficacy of SAR442085 was promising in anti‐CD38 mAb naïve patients but did not extend to the larger cohort of anti‐CD38 mAb pre‐treated patients. This observation, along with transient high‐grade thrombocytopenia, could potentially limit its clinical use.
Prediction of sustained remission after tyrosine kinase inhibitor discontinuation with BCR::ABL1 digital PCR in chronic myeloid leukemia patients
Authors: Kockerols Camille , Valk Peter J. M. , Janssen Jeroen J. W. M. , Hogenbirk Pauline , Cornelissen Jan J. , Saussele Susanne , Spiess Birgit , Perusini Maria Agustina , Kim Dennis , Westerweel Peter E. 
Published: July 2024

AbstractPrecise and reliable predictive parameters to accurately identify chronic myeloid leukemia (CML) patients who can successfully discontinue their tyrosine kinase inhibitor (TKI) treatment are lacking. One promising parameter is depth of molecular response measured by BCR::ABL1 digital PCR (dPCR). The aim of this study was to validate a previously described prediction cutoff of 0.0023%IS and to assess the value of dPCR for treatment‐free remission (TFR) prediction in relation to other clinical parameters. A droplet‐based dPCR assay assessed BCR::ABL1 %IS prior to TKI discontinuation. The primary endpoint was molecular recurrence (MolR) by 36 months. A total of 186 patients from Canada, Germany, and the Netherlands were included. In patients with a first TKI discontinuation attempt (n = 163), a BCR::ABL1 dPCR < and ≥0.0023%IS had a MolR probability of 33% and 70%, respectively. Patients treated less than 6 years with a BCR::ABL1 dPCR <0.0023%IS had a MolR probability of 31%. After correction for treatment duration, both high dPCR value and the use of imatinib (vs. second‐generation TKI) were significantly associated with a higher risk of MolR (HR of 3.66, 95%CI 2.06–6.51, p < .001; and 2.85, 95%CI 1.25–6.46, p = .013, respectively). BCR::ABL1 dPCR was not associated with TFR outcome after second TKI discontinuation, however, with the limitation of a small number of patients analyzed (n = 23). In conclusion, BCR::ABL1 digital PCR based on the cutoff of 0.0023%IS is a valuable predictive tool to identify CML patients with a high probability of TFR success after first TKI discontinuation, including patients treated for less than 6 years.
The impact of hematology electronic consultations on the management of iron deficiency
Authors: King Hannah L. , Benedetti Genevieve B. , Barisic Stefan , Tan Virginia , Piatski Marie E. , Berkowitz Jacob M. , Benson Ashley E. , Lo Jamie O. , Olson Sven R. , DeLoughery Thomas G. , Shatzel Joseph J. , Martens Kylee L. 
Published: July 2024

AbstractObjectivesDelays in the evaluation and treatment of iron deficiency can lead to increased disease‐related morbidity and mortality. Electronic consultation (e‐consult) is a referral modality that allows providers quicker access to recommendations from a specialist based on electronic chart review. While the use of e‐consult is expanding in classical hematology, gaps exist in the understanding of patient outcomes related to its use for iron deficiency.MethodsWe randomly selected 200 e‐consults and 200 traditional referrals from 3,336 hematology referrals for iron deficiency at a single center. The primary outcomes of the retrospective analysis were: time to completion of the referral, and time to treatment with intravenous iron. Secondary outcomes included recurrence of iron deficiency, need for repeat e‐consult, conversion to in‐person evaluation, and assessment of whether the etiology of iron deficiency was addressed.ResultsE‐consults significantly reduced the time from referral to intravenous iron repletion (e‐consult, 33 days; traditional referral, 68 days; p < .05). Assessment of the underlying etiology occurred in 70.7% of the e‐consult encounters compared to 92.5% of traditional referrals (p < .05).ConclusionsThese findings highlight advantages of e‐consults in improving care delivery in iron deficiency, and identifying gaps that can be improved through practice standardization to ensure equitable, high‐value care.
A generative adversarial network‐based client‐level handwriting forgery attack in federated learning scenario
Authors: Shi Lei , Wu Han , Ding Xu , Xu Hao , Pan Sinan 
Published: July 2024

AbstractFederated learning (FL), celebrated for its privacy‐preserving features, has been revealed by recent studies to harbour security vulnerabilities that jeopardize client privacy, particularly through data reconstruction attacks that enable adversaries to recover original client data. This study introduces a client‐level handwriting forgery attack method for FL based on generative adversarial networks (GANs), which reveals security vulnerabilities existing in FL systems. It should be stressed that this research is purely for academic purposes, aiming to raise concerns about privacy protection and data security, and does not encourage illegal activities. Our novel methodology assumes an adversarial scenario wherein adversaries intercept a fraction of parameter updates via victim clients’ wireless communication channels, then use this information to train GAN for data recovery. Finally, the purpose of handwriting imitation is achieved. To rigorously assess and validate our methodology, experiments were conducted using a bespoke Chinese digit dataset, facilitating in‐depth analysis and robust verification of results. Our experimental findings demonstrated enhanced data recovery effectiveness, a client‐level attack and greater versatility compared to prior art. Notably, our method maintained high attack performance even with a streamlined GAN design, yielding increased precision and significantly faster execution times compared to standard methods. Specifically, our experimental numerical results revealed a substantial boost in reconstruction accuracy by 16.7%, coupled with a 51.9% decrease in computational time compared to the latest similar techniques. Furthermore, tests on a simplified version of our GAN exhibited an average 10% enhancement in accuracy, alongside a remarkable 70% reduction in time consumption. By surmounting the limitations of previous work, this study fills crucial gaps and affirms the effectiveness of our approach in achieving high‐accuracy client‐level data reconstruction within the FL context, thereby stimulating further exploration into FL security measures.
Identifying a typology of helpful post‐divorce family assets: Implications for divorce education
Authors: Beckmeyer Jonathon J. , Russell Luke T. 
Published: July 2024

AbstractDivorce education programs seek to provide parents with information about various aspects of the divorce process, its consequences, and strategies for successful adjustment. Within those broad content areas, however, there are myriad of potential promotive‐, protective‐, and risk‐factors that programs could address. Thus, divorce education programs could benefit from further guidance about the content areas divorcing parents may find the most helpful. In the present study we aimed to describe what divorced parents felt had helped their families throughout the divorce process. We did so to promote further alignment between divorce education program content and what parents have found helpful. Specifically, we identified a typology of helpful post‐divorce family assets. Our findings suggest that though a plurality of divorcing parents benefit from a wide range of legal/professional, former spouse, and personal assets, the majority rely predominately upon their own parenting skills and resources, or perceive few beneficial assets to draw on. We contend divorce educators should consider incorporating further information on developing personal parenting skills or resources, and skillfully navigating legal or therapeutic systems, to further complement existing curricula.