bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of biaxial strain of poly(l‐lactide) tubes
Authors: Løvdal Alexandra , Andreasen Jens W , Mikkelsen Lars P , Agersted Karsten , Almdal Kristoffer 
Published: October 2015

AbstractPoly(l‐lactide) in its l‐form has promising mechanical properties. Being a semicrystalline polymer, it can be subjected to strain‐induced crystallization at temperatures above Tg and can thereby become oriented. Following a simultaneous (SIM) biaxial strain process or a sequential (SEQ) biaxial strain process, the mechanical properties of biaxially strained tubes can be further improved. This study investigated these properties in relation to their morphology and crystal orientation. Both processes yield the same mechanical strength and modulus, yet exhibit different crystal orientation. Through further wide angle X‐ray scattering analysis it was found that the SEQ biaxial strain yields larger interplanar spacing and distorted crystals and looser packing of chains. However, this does not influence the mechanical properties negatively. A loss of orientation in SEQ biaxially strained samples at high degrees of strain was detected, but was not seen for SIM biaxial strain and did not correlate with mechanical performance in either case. However, post‐annealing reduced the orientation to the same level in both cases, and the modulus and strength decreased for both SIM and SEQ biaxial strain. It is therefore concluded that mechanical properties after biaxial strain are related to strain‐induced amorphous orientation and the packing of crystals, rather than strain‐induced crystallinity. © 2015 Society of Chemical Industry
Controlled radical polymerization of fluorinated methacrylates in supercritical CO2: Synthesis and application of a novel RAFT agent
Authors: Chen Jian‐Gang , Feng Xian , Wang Ming‐Xi , Shen Shukun , Li Yang , Wang Wei , Liu Zhao‐Tie , Liu Zhong‐Wen , Jiang Jinqiang , Lu Jian 
Published: October 2015

ABSTRACTA novel fluorinated reversible addition‐fragmentation chain transfer agent, S,S‐di‐pentaflourobenzyl trithiocarbonate (DPFBTTC), was designed and synthesized. DPFBTTC and dibenzyl trithiocarbonate (DBTTC) were applied in the polymerization of dodecafluoroheptyl methacrylate (DFHMA), hexafluorobutyl methacrylate (HFBMA), and trifluoroethyl methacrylate (TFEMA) in scCO2. The polymerization processes were monitored using a high‐pressure in‐situ NIR, through which the polymerization kinetics was investigated and the controllability of DPFBTTC was evaluated. It is found that the controllability of DPFBTTC presented in the order of DFHMA > HFBMA > TFEMA, indicating that DPFBTTC may fit for the controlled polymerization of the highly fluorinated methacrylates. Moreover, the controllability of DPFBTTC is verified to be better than that of DBTTC, possibly resulting from the enhanced accessibility/miscibility of DPFBTTC to the fluorinated monomer used. We believe that the employment of DPFBTTC and the resulted introduction of stable pentafluorobenzyl end groups to the polymer are expected to distinctly improve performances of the polymer, and thus will meet the special application requirements. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 825–834
A convenient synthesis of α,α′‐ homo‐ and α,α′‐hetero‐bifunctionalized poly(ε‐caprolactone)s by ring opening polymerization: The potentially valuable precursors for miktoarm star copolymers
Authors: Patil Sachin S. , Tawade Bhausaheb V. , Wadgaonkar Prakash P. 
Published: October 2015

ABSTRACTTwo new ring opening polymerization (ROP) initiators, namely, (3‐allyl‐2‐(allyloxy)phenyl)methanol and (3‐allyl‐2‐(prop‐2‐yn‐1‐yloxy)phenyl)methanol each containing two reactive functionalities viz. allyl, allyloxy and allyl, propargyloxy, respectively, were synthesized from 3‐allylsalicyaldehyde as a starting material. Well defined α‐allyl, α′‐allyloxy and α‐allyl, α′‐propargyloxy bifunctionalized poly(ε‐caprolactone)s with molecular weights in the range 4200–9500 and 3600–10,900 g/mol and molecular weight distributions in the range 1.16–1.18 and 1.15–1.16, respectively, were synthesized by ROP of ε‐caprolactone employing these initiators. The presence of α‐allyl, α′‐allyloxy and α‐allyl, α′‐propargyloxy functionalities on poly(ε‐caprolactone)s was confirmed by FT‐IR, 1H, 13C NMR spectroscopy, and MALDI‐TOF analysis. The kinetic study of ROP of ε‐caprolactone with both the initiators revealed the pseudo first order kinetics with respect to ε‐caprolactone consumption and controlled behavior of polymerization reactions. The usefulness of α‐allyl, α′‐allyloxy functionalities on poly(ε‐caprolactone) was demonstrated by performing the thiol‐ene reaction with poly(ethylene glycol) thiol to obtain (mPEG)2‐PCL miktoarm star copolymer. α‐Allyl, α′‐propargyloxy functionalities on poly(ε‐caprolactone) were utilized in orthogonal reactions i.e copper catalyzed alkyne‐azide click (CuAAC) with azido functionalized poly(N‐isopropylacrylamide) followed by thiol‐ene reaction with poly(ethylene glycol) thiol to synthesize PCL‐PNIPAAm‐mPEG miktoarm star terpolymer. The preliminary characterization of A2B and ABC miktoarm star copolymers was carried out by 1H NMR spectroscopy and gel permeation chromatography (GPC). © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 844–860
Cost Effectiveness of a Fast‐Track Protocol for Urgent Laparoscopic Cholecystectomies and Appendectomies
Authors: Trevino Colleen M. , Katchko Karina M. , Verhaalen Amy L. , Bruce Marie L. , Webb Travis P. 
Published: October 2015

AbstractBackgroundFast‐track protocols (FTPs) are used to decrease length of stay (LOS) and hospital costs for elective outpatient procedures. Few institutions have implemented FTP for urgent procedures such as laparoscopic cholecystectomy (LC) and laparoscopic appendectomy (LA).Study designThis is a retrospective single‐institution cohort study including all patients undergoing urgent LC or LA between July 1, 2010 and May 1, 2013. Exclusion criteria included conversion to open procedure, perforated appendicitis, or procedure related to intra‐abdominal injury. Analysis included a comparison of the three study groups: (1) before (PRE) and after (POST) implementation of the fast‐track protocol (FTP), (2) fast‐track cohort (FT) and non‐fast‐track cohort (NFT), and (3) those completing the fast‐track pathway (FT‐C) and those who began but failed to complete the pathway (FT‐F).ResultsThere were significant reductions in LOS between all study groups compared: between PRE (n = 256) and POST (n = 472) cohorts by half a day (2.0 vs. 1.5 days, p < 0.02); between FT and NFT (0.68 vs. 1.82 days, p < 0.01); and FT‐C and FT‐F (0.49 vs. 1.05 days, p < 0.01). Total hospital charges were significantly reduced in FT compared with NFT ($22,347 vs. $30,868, p < 0.01) with an average savings of $8521. Total hospital charges were decreased in the FT‐C compared with FT‐F cohorts ($21,971 vs. $22,939, p = 0.3) with an average savings of $968. Readmissions, complications, and satisfaction were similar for all comparison groups.ConclusionsFTPs for urgent appendectomies and cholecystectomies can significantly reduce hospital costs by reducing LOS without compromising patient outcomes.
Intraoperative Contrast‐Enhanced Ultrasound in Colorectal Liver Metastasis Surgery Improves the Identification and Characterization of Nodules
Authors: Hoareau Julien , Venara Aurélien , Lebigot Jérôme , Hamel Jean‐Francois , Lermite Emilie , Caroli‐Bosc Francois Xavier , Aube Christophe 
Published: October 2015

AbstractIntroductionThe sensitivity of preoperative assessment of colorectal liver metastases (CRLM) ranges from 74 to 80 %. Intraoperative ultrasound (IOUS) associated with contrast‐enhanced intraoperative ultrasound (CE‐IOUS) may be able to improve this. Thus, the aims of this study were to assess the value of IOUS and CE‐IOUS for the surgical approach and to determine risk factors both for the detection of new nodules and for the modification of the surgical strategy.Materials and methodsForty‐three patients who underwent CRLM surgery were included. These patients had an MRI in the 8 weeks preceding surgery and benefited from intraoperative IOUS and CE‐IOUS.Results and discussionThe use of IOUS/CE‐IOUS permitted the identification of 43 additional lesions and an improved characterization of nodules in 23 patients with a resulting modification of surgical strategy. Lesions were down‐staged in six patients and up‐staged in six patients. Chemotherapy (p = 0.02) and the presence of nodules in the left lobe (p = 0.04) were predictive factors for finding new nodules at IOUS/CE‐IOUS. The discovery of a new nodule systematically modified surgical management. IOUS/CE‐IOUS improved intraoperative management of liver metastases. The techniques enable pertinent modification of surgical resections and a reduction of residual lesions.
Density-ratio effects on the capture of suspended particles in aquatic systems
Authors: Espinosa-Gayosso Alexis , Ghisalberti Marco , Ivey Gregory N. , Jones Nicole L. 
Published: October 2015

Particle capture, whereby suspended particles contact and adhere to a solid surface (a ‘collector’), is important in a range of environmental processes, including suspension feeding by corals and ‘filtering’ by aquatic vegetation. Although aquatic particles are often considered as perfect tracers when estimating capture efficiency, the particle density ratio (${\it\rho}^{+}$) – the ratio of the particle density to the fluid density – can significantly affect capture. In this paper, we use a numerical analysis of particle trajectories to quantify the influence of${\it\rho}^{+}$on particle capture by circular collectors in a parameter space relevant to aquatic systems. As it is generally believed that inertia augments the capture efficiency when the Stokes number ($\mathit{St}$) of the particles exceeds a critical value, we first estimate the critical Stokes number for aquatic-type particles and demonstrate its dependence on both${\it\rho}^{+}$and the Reynolds number ($\mathit{Re}$). Second, we analyse how efficiently circular collectors can capture neutrally buoyant (${\it\rho}^{+}=1$), sediment-type (${\it\rho}^{+}=2.6$) and weakly buoyant (${\it\rho}^{+}=0.9$) aquatic particles. Our analysis shows that, for${\it\rho}^{+}>1$, inertia can either augment or diminish capture efficiency, and inertial effects appear well before the critical Stokes number is reached. The role of particle inertia is maximised at Stokes numbers above the critical value and, for sediment-type particles, can result in as much as a fourfold increase in the rate of capture relative to perfect tracers of the same size. Similar but opposite effects are observed for weakly buoyant particles, where capture efficiency can decrease by 60 % relative to the capture of perfect tracers.
Long-term treatment with haloperidol affects neuropeptide S and NPSR mRNA levels in the rat brain
Authors: Palasz Artur , Rojczyk Ewa , Golyszny Milosz , Filipczyk Lukasz , Worthington John J. , Wiaderkiewicz Ryszard 
Published: October 2015

ObjectiveThe brainstem-derived neuropeptide S (NPS) has a multidirectional regulatory activity, especially as a potent anxiolytic factor. Accumulating data suggests that neuroleptics affect peptidergic signalling in various brain structures. However, there is no information regarding the influence of haloperidol on NPS and NPS receptor (NPSR) expression.MethodsWe assessed NPS and NPSR mRNA levels in brains of rats treated with haloperidol using quantitative real-time polymerase chain reaction.ResultsChronic haloperidol treatment (4 weeks) led to a striking upregulation of NPS and NPSR expression in the rat brainstem. Conversely, the NPSR mRNA expression was decreased in the hippocampus and striatum.ConclusionsThis stark increase of NPS in response to haloperidol treatment supports the hypothesis that this neuropeptide is involved in the dopamine-dependent anxiolytic actions of neuroleptics and possibly also in the pathophysiology of mental disorders. Furthermore, our findings underline the complex nature of potential interactions between dopamine receptors and brain peptidergic pathways, which has potential clinical applications.
Molecular characterization ofOpisthorchis noverca(Digenea: Opisthorchiidae) based on nuclear ribosomal ITS2 and mitochondrial COI genes
Authors: Sahu R. , Biswal D.K. , Roy B. , Tandon V. 
Published: October 2015

AbstractOpisthorchiasis is a public health problem in South-East Asian countries and Eastern Europe. The infection implicates mainly two species ofOpisthorchis, namelyO. viverriniandO. felineus,that occur mostly in fish-eating mammals and humans, although there are rare reports of human cases involving two other species,O. novercaandO. guayaquilensis.Opisthorchis novercahas been reported frequently in dogs and pigs from the Indian subcontinent, with rare reports from cattle and human subjects. With a view to supplementing morphology-based identification of this species, the present study aimed to provide molecular characterization ofO. noverca, using rDNA internal transcribed spacer 2 (ITS2) and mitochondrial cytochrome oxidase I (mt COI) markers so as to determine its genetic correlation with other species of Opisthorchiidae, and also to generate a taxon-specific molecular marker based on the ITS2 region. The phylogenetic relationship betweenO. novercaand other species of the genus was determined using molecular sequence data. To strengthen the result, secondary structure sequence analyses of ITS2 with hemi-compensatory base changes (hCBCs), and amino acid sequence analyses, were also evaluated. Our results confirm thatO. novercais a distinct and valid species.
The suffering of Christ, humanity and the lepers in Gregory Nazianzen
Authors: Wessel Susan 
Published: October 2015

AbstractGregory Nazianzen spoke of a suffering Christ ‘who became weak for us’ in the context of an oration,On Love of the Poor, which dealt at length with the extreme suffering the lepers had endured. The outcasts of the ancient world, lepers figured prominently in Jesus’ ministry as recorded in the Gospels. By juxtaposing their human suffering with divine weakness, Gregory implied that Christ had suffered with the lepers. The comparison not only gave meaning to the human experience of suffering, it also explored the extent of Christ's suffering in the divine economy. There was no affliction too grotesque for Christ to have assumed.Throughout his life, Gregory developed a notion of collective suffering which is relevant to understanding the magnitude of the suffering of Christ. It made the limitless suffering of humanity seem manageable and contained. It normalised the overwhelming sense of misery by expanding individual suffering into the suffering of the group, the suffering of the group into the suffering of neighbours and finally the suffering of neighbours into the collective suffering of the body of Christ. Christ then experienced the fullness of the human condition as the head of this body.The lepers served a purpose in this vision of collective suffering. By making the lepers a synecdoche for all human suffering, Gregory allowed Christ to assume their misery without his listeners having to imagine Christ suffering every aspect of their physical and emotional distress. This transference of collective suffering to the body of Christ worked in the following way: the individual suffering of the leper flowed into the collective suffering of the group, which connected with, and was incorporated into, the collective suffering of the Christian body. The result was a relationship of mutual imitation between Christ and humanity. It implied that human beings suffered with Christ, and that Christ suffered with human beings.By integrating literary techniques and contexts into theological analysis, this article examines the various ways in which Gregory construed the suffering of Christ.
Intersectionality and the social meanings of variation: Class, ethnicity, and social practice
Authors: Kirkham Sam 
Published: October 2015

AbstractThis article examines how the social meanings of phonetic variation in a British adolescent community are influenced by a complex relationship between ethnicity, social class, and social practice. I focus on the realisation of thehappyvowel in Sheffield English, which is reported to be a lax variant [ε̈] amongst working-class speakers but is undergoing change towards a tense variant [i] amongst middle-class speakers. I analyse the acoustic realisation of this vowel across four female communities of practice in a multiethnic secondary school and find that the variable's community-wide associations of social class are projected onto the ethnographic category of school orientation, which I suggest is a more local interpretation of class relations. Ethnographic evidence and discourse analysis reveal that local meanings of thehappyvowel vary further within distinctive community of practice styles, which is the result of how ethnicity and social class intersect in structuring local social practices. (Intersectionality, indexicality, social meaning, identity, ethnicity, social class)*
‘Putting a face on a community’: Genre, identity, and institutional regulation in the telling (and retelling) of oral coming-out narratives
Authors: DiDomenico Stephen M. 
Published: October 2015

AbstractPublic and scholarly discourse has established the ‘coming-out story’ as a culturally significant narrative genre for gay, bisexual, transgender, and queer-identifying (LGBTQ) individuals. Yet what happens when this genre is disciplined and managed for institutional ends? This study examines the process of how several LGBTQ individuals learn to narrate their coming-out experiences through trainings for a university's LGBTQ-themed speaker panels. Data include ethnographic observations and audio recordings related to training activities such as practice tellings and peer feedback sessions. Analysis focuses on the discursive practices through which training participants manage a pair of narrative dilemmas that stem from an institutional variation of the coming-out genre. This article contributes to literature on narrative and genre by demonstrating how a regulated form of personal narrative is learned and enforced to achieve the larger ideological aims of an institution. It also contributes to knowledge about identity as a fluid concept. (Coming-out story, genre, narrative, identity, ideology, performance, LGBTQ)*
The electoral foundations to noncompliance: addressing the puzzle of unlawful state aid in the European Union
Authors: Franchino Fabio , Mainenti Marco 
Published: October 2015

AbstractElectoral institutions shape the incentives of governments to rely on distributive measures and to comply with international obligations because of the misalignment they may engender between the collective objectives of a government party and the individual objectives of its members in the legislature. We use this argument to explain the puzzle of unlawful state aid measures in the European Union (EU). Existing theories of EU compliance and implementation offer no convincing explanation to their persistence and patterns. Using data from 2000 to 2012, we find that an increase of district magnitude improves compliance. However, compliance decreases with higher magnitude where either party leaders have no control over the ballot rank or other electoral rules strengthen the incentives to search for a personal vote. We also provide evidence for the effects of electoral reforms on compliance. These results have implications for the broader literature on compliance with international regimes.
Non-commutative Iwasawa theory for elliptic curves with multiplicative reduction
Authors: DELBOURGO DANIEL , LEI ANTONIO 
Published: October 2015

AbstractLet$E_{/{\mathbb{Q}}}$be a semistable elliptic curve, andp≠ 2 a prime of bad multiplicative reduction. For each Lie extension$\mathbb{Q}$FT/$\mathbb{Q}$with Galois groupG∞≅$\mathbb{Z}$p⋊$\mathbb{Z}$p×, we constructp-adicL-functions interpolating Artin twists of the Hasse–WeilL-series of the curveE. Through the use of congruences, we next prove a formula for the analytic λ-invariant over the false Tate tower, analogous to Chern–Yang Lee's results on its algebraic counterpart. If one assumes the Pontryagin dual of the Selmer group belongs to the$\mathfrak{M}_{\mathcal{H}}$(G∞)-category, the leading terms of its associated Akashi series can then be computed, allowing us to formulate a non-commutative Iwasawa Main Conjecture in the multiplicative setting.
Clocked lambda calculus
Authors: ENDRULLIS JÖRG , HENDRIKS DIMITRI , KLOP JAN WILLEM , POLONSKY ANDREW 
Published: October 2015

One of the best-known methods for discriminating λ-terms with respect to β-convertibility is due to Corrado Böhm. The idea is to compute the infinitary normal form of a λ-term M, the Böhm Tree (BT) of M. If λ-terms M, N have distinct BTs, then M ≠βN, that is, M and N are not β-convertible. But what if their BTs coincide? For example, all fixed point combinators (FPCs) have the same BT, namely λx.x(x(x(. . .))).We introduce a clocked λ-calculus, an extension of the classical λ-calculus with a unary symbol τ used to witness the β-steps needed in the normalization to the BT. This extension is infinitary strongly normalizing, infinitary confluent and the unique infinitary normal forms constitute enriched BTs, which we call clocked BTs. These are suitable for discriminating a rich class of λ-terms having the same BTs, including the well-known sequence of Böhm's FPCs.We further increase the discrimination power in two directions. First, by a refinement of the calculus: the atomic clocked λ-calculus, where we employ symbols τp that also witness the (relative) positions p of the β-steps. Second, by employing a localized version of the (atomic) clocked BTs that has even more discriminating power.
HOI-02 induces apoptosis and G2-M arrest in esophageal cancer mediated by ROS
Authors: Zhang C , Liu K , Yao K , Reddy K , Zhang Y , Fu Y , Yang G , Zykova T A , Shin S H , Li H , Ryu J , Jiang Y-n , Yin X , Ma W , Bode A M , Dong Z , Dong Z 
Published: October 2015

AbstractReactive oxygen species (ROS) are chemically reactive molecules that perform essential functions in living organisms. Accumulating evidence suggests that many types of cancer cells exhibit elevated levels of ROS. Conversely, generation of ROS has become an effective method to kill cancer cells. (E)-3-hydroxy-3-(4-(4-nitrophenyl)-2-oxobut-3-en-1-yl) indolin-2-one, which is an NO2 group-containing compound designated herein as HOI-02, generated ROS and, in a dose-dependent manner, decreased esophageal cancer cell viability and inhibited anchorage-independent growth, followed by apoptosis and G2-M arrest. Moreover, results of an in vivo study using a patient-derived xenograft mouse model showed that HOI-02 treatment suppressed the growth of esophageal tumors, without affecting the body weight of mice. The expression of Ki-67 was significantly decreased with HOI-02 treatment. In addition, the phosphorylation of c-Jun, and expression of p21, cleaved caspase 3, and DCFH-DA were increased in the HOI-02-treated group compared with the untreated control group. In contrast, treatment of cells with (E)-3-(4-(4-aminophenyl)-2-oxobut-3-en-1-yl)-3-hydroxyindolin-2-one, which is an NH2 group-containing compound designated herein as HOI-11, had no effect. Overall, we identified HOI-02 as an effective NO2 group-containing compound that was an effective therapeutic or preventive agent against esophageal cancer cell growth.