bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ex Vivo Antibody-Dependent Cellular Cytotoxicity Inducibility Predicts Efficacy of Cetuximab
Authors: Taylor Rodney J. , Saloura Vassiliki , Jain Ajay , Goloubeva Olga , Wong Stuart , Kronsberg Shari , Nagilla Madhavi , Silpino Lorna , de Souza Jonas , Seiwert Tanguy , Vokes Everett , Villaflor Victoria , Cohen Ezra E.W. 
Published: March 2015

Abstract
We conducted in vitro studies and a clinical trial for patients with squamous cell carcinoma of the head and neck (SCCHN) to study the relationship between FcγRIIIa polymorphisms and antibody-dependent cellular cytotoxicity (ADCC). In vitro, FcγRIIIa genotype was correlated with ADCC and innate cytotoxicity using natural killer (NK) cells harvested from healthy donors. In the phase II study, patients with recurrent or metastatic SCCHN were treated with cetuximab (500 mg/m2 i.v. every 2 weeks) and lenalidomide (25 mg daily). FcγRIIIa genotype and ex vivo ADCC were correlated with clinical response, progression-free survival (PFS), and overall survival (OS). In vitro, healthy donors with a FcγRIIIa 158-V allele demonstrated more effective ADCC against two colon cancer cell lines HT29 and SW480, mean cytotoxicity: FF 16.1%, VF/VV 24.3% (P = 0.015) and FF 11.7%, VF/VV 21.0% (P = 0.008), respectively. We observed a linear relationship between ADCC response and innate cytotoxicity. In the phase II trial, 40 patients received cetuximab and lenalidomide with median PFS of 7.2 weeks and OS of 16.4 weeks. Thirty-six patients had FcγRIIIa genotype: VV (2), VF (20), and FF (14), and 25 patients had sufficient NK-cell yield to perform ex vivo ADCC. FcγRIIIa genotype was not associated with any clinical outcomes. Patients mounting ex vivo ADCC response had a higher likelihood of stable disease (P = 0.01) and showed a trend toward increased PFS: 14 weeks versus 6.8 weeks, respectively (P = 0.13). Enhanced ex vivo ADCC and innate immunity responses were more predictive of clinical response than FcγRIIIa and may offer a functional assay to select patients suitable for cetuximab therapy. Cancer Immunol Res; 3(5); 567–74. ©2015 AACR.
Long-Term Outcomes of Secondary Atrial Fibrillation in the Community
Authors: Lubitz Steven A. , Yin Xiaoyan , Rienstra Michiel , Schnabel Renate B. , Walkey Allan J. , Magnani Jared W. , Rahman Faisal , McManus David D. , Tadros Thomas M. , Levy Daniel , Vasan Ramachandran S. , Larson Martin G. , Ellinor Patrick T. , Benjamin Emelia J. 
Published: March 2015

Background—
Guidelines have proposed that atrial fibrillation (AF) can occur as an isolated event, particularly when precipitated by a secondary, or reversible, condition. However, knowledge of long-term AF outcomes after diagnosis during a secondary precipitant is limited.

Methods and Results—
In 1409 Framingham Heart Study participants with new-onset AF, we examined associations between first-detected AF episodes occurring with and without a secondary precipitant and both long-term AF recurrence and morbidity. We selected secondary precipitants based on guidelines (surgery, infection, acute myocardial infarction, thyrotoxicosis, acute alcohol consumption, acute pericardial disease, pulmonary embolism, or other acute pulmonary disease). Among 439 patients (31%) with AF diagnosed during a secondary precipitant, cardiothoracic surgery (n=131 [30%]), infection (n=102 [23%]), noncardiothoracic surgery (n=87 [20%]), and acute myocardial infarction (n=78 [18%]) were most common. AF recurred in 544 of 846 eligible individuals without permanent AF (5-, 10-, and 15-year recurrences of 42%, 56%, and 62% with versus 59%, 69%, and 71% without secondary precipitants; multivariable-adjusted hazard ratio, 0.65 [95% confidence interval, 0.54–0.78]). Stroke risk (n=209/1262 at risk; hazard ratio, 1.13 [95% confidence interval, 0.82–1.57]) and mortality (n=1098/1409 at risk; hazard ratio, 1.00 [95% confidence interval, 0.87–1.15]) were similar between those with and without secondary precipitants, although heart failure risk was reduced (n=294/1107 at risk; hazard ratio, 0.74 [95% confidence interval, 0.56–0.97]).

Conclusions—
AF recurs in most individuals, including those diagnosed with secondary precipitants. Long-term AF-related stroke and mortality risks were similar between individuals with and without secondary AF precipitants. Future studies may determine whether increased arrhythmia surveillance or adherence to general AF management principles in patients with reversible AF precipitants will reduce morbidity.
Mental health of internally displaced persons in Jalozai camp, Pakistan
Authors: Mujeeb Arooj 
Published: March 2015

Background: Internal displacement has been a distressing issue of Pakistan for last one decade. Few research works have been conducted on the psychological issues of internally displaced persons in Pakistan. Aims: The current research was aimed at determining the psychological effects of internal displacement, that is, psychological well-being, depression, anxiety and stress (internalizing problems) of the individuals who were displaced as a result of an armed conflict in Swat. Method: A sample of 126 internally displaced persons was taken from Jalozai camp which included females ( n = 65) and males ( n = 61). Age of the sample ranged from 20 to 75 years with a mean of 47.5 years. Translated and adapted versions of Well-Being Affectometer-2 Scale and Depression Anxiety Stress Scale were used in the current research. Results: Results of the study indicated differences between males and females, females being higher on internalizing problems and lower on psychological well-being, whereas family loss during displacement affected the results in the same way. Well-being, gender and family loss emerged as significant predictors of internalizing problems, and gender moderated the relationship between well-being and internalizing problems. Conclusion: Internal displacement may bring psychological issues for internally displaced persons, that is, their well-being may decrease and depression, anxiety and stress may increase during displacement. Limitations and implications of the study were discussed further.
Applying the CHIME recovery framework in two culturally diverse Australian communities: Qualitative results
Authors: Brijnath Bianca 
Published: March 2015

Background: CHIME (connectedness, hope and optimism about the future, identity, meaning in life and empowerment) is a framework for conceptualising personal recovery from mental illness. To date, there has been limited research on its cross-cultural applicability. Aims: To apply CHIME to two culturally diverse groups’ conceptualisation of recovery from depression. Method: Qualitative interviews with 30 Anglo-Australians and 28 Indian-Australians living with depression in Melbourne, Australia. Data were thematically analysed. Results: Both groups valued connectedness but experienced stigma and struggled to broker family support. Identity, hope and optimism for the future were associated with positive thinking, being ‘cured’ and discontinuing treatment. Spirituality gave Indian participants meaning in life; Anglos derived meaning from the illness experience itself. Feeling empowered, for both groups, was related to improved socio-economic status and being ‘settled’ (e.g. having gainful employment, a home and family). Conclusions: CHIME was applicable in both groups, but culture mediated how cross-cutting issues (e.g. stigma) and sub-components of CHIME were operationalised. Recovery was also influenced by participant’s socio-economic context. Research, policy and practice implications are discussed.
The attributable burden of panic disorder in the impairment of quality of life in a national survey in Italy
Authors: Carta Mauro Giovanni , Moro Maria Francesca , Aguglia Eugenio , Balestrieri Matteo , Caraci Filippo , Dell’Osso Liliana , Di Sciascio Guido , Drago Filippo , Hardoy Maria Carolina , D’Aloja Ernesto , Machado Sergio , Roncone Rita , Faravelli Carlo 
Published: March 2015

Introduction/Objective: The aim was to measure the lifetime prevalence of panic disorder (PD) in an Italian community sample, and to estimate the burden attributable to PD in compromising the quality of life (QoL) of people diagnosed with it. Methods: Community survey was conducted on a sample of 4,999 randomly selected adult subjects. Instruments used were semi-structured clinical interview Advanced Neuropsychiatric Tools and Assessment Schedule (ANTAS), administered by clinicians and allowing diagnosis according to Diagnostic and Statistical Manual of Mental Disorder (4th ed.; DSM-IV); Short Form Health Survey (SF-12). Results: The lifetime prevalence of PD was 3.6% (4.4% in females, 2.5% in males; p = .002). People with PD had a lower SF-12 score than the standardized community sample (35.5 ± 6.5 vs. 38.4 ± 5.9; p < .0001) with a mean difference (attributable burden) of 2.9 ± 0.7, that is, lower than PD with agoraphobia (AP; 4.2 ± 2.4). Wilson Disease (WD), Multiple Sclerosis, Major Depressive Disorder and Eating Disorders (ED) show a higher attributable burden in impaired QoL than PD, while the attributable burden of PD with AP is not lower than in ED and WD. Conclusions: The burden attributable to the impairment of QoL following a lifetime diagnosis of PD was found to be not so great compared to the impairment caused by Major Depressive Disorder (MDD) or neurological conditions. The comorbidity of PD with AP worsens QoL significantly.
Credentialing Structures, Pedagogies, Practices, and Curriculum Goals
Authors: Ayers David F. 
Published: March 2015

Objective: To examine the discursive strategies deployed by community colleges to sustain legitimacy in an evolving and contradictory institutional environment. Method: Using corpus linguistics software, I compared 1,009 mission statements from 2012-2013 with a reference corpus of 427 mission statements from 2004. Results: Keywords analysis, collocation analysis, and concordance analysis suggest that mission statements have changed along four discourse trajectories: credentialing structures, pedagogies, practices, and curriculum goals. Contributions: These findings situate the community college as a point of entry into understanding the relations among institutional legitimacy and a changing cultural, political, and economic milieu.
The Online STEM Classroom—Who Succeeds? An Exploration of the Impact of Ethnicity, Gender, and Non-traditional Student Characteristics in the Community College Context
Authors: Wladis Claire , Conway Katherine M. , Hachey Alyse C. 
Published: March 2015

Objective: This study analyzes how ethnicity, gender, and non-traditional student characteristics relate to differential online versus face-to-face outcomes in science, technology, engineering, and mathematics (STEM) courses at community colleges. Method: This study used a sample of 3,600 students in online and face-to-face courses matched by course, instructor, and semester from a large urban community college in the Northeast. Outcomes were measured using rates of successful course completion (with a “C−” or higher). Multilevel logistic regression and propensity score matching were utilized to control for unobserved heterogeneity between courses and for differences in student characteristics. Results: With respect to successful course completion, older students did significantly better online, and women did significantly worse (although no worse than men) online, than would be expected based on their outcomes in comparable face-to-face courses. There was no significant interaction between the online medium and ethnicity, suggesting that though Black and Hispanic students may do worse on average in STEM courses than their White and Asian peers both online and face-to-face, this gap was not increased by the online environment. Contributions: These findings suggest that both women and younger students in STEM courses may need extra support in the online environment. Future research is needed (a) to explore whether factors such as stereotype threat or child care responsibilities affect the outcomes of women in online STEM courses, and (b) to determine which characteristics (e.g., motivation, self-directed learning skills) of older students may make them particularly well suited to the online environment.
Ruta Mixteca
Authors: Stavenhagen Rodolfo 
Published: March 2015

“Ruta Mixteca” is the name given to the circular migrations of indigenous farm workers between the Mexican state of Oaxaca and California long studied by Michael Kearney and his collaborators. Indigenous migrations to the United States have expanded in recent years as a result of the North American Free Trade Agreement and changes in Mexico’s agrarian legislation that led to increased privatization of land and natural resources, dispossession of the traditional peasantry, and numerous local land- and resource-related conflicts. The Zapatista uprising stimulated the growth of a host of militant indigenous organizations, now also emboldened by constitutional changes that recognize the human rights of indigenous peoples according to international standards. Indigenous transnational migrations need to adapt to these changing conditions. “Ruta Mixteca” es el nombre dado a las migraciones circulares de campesinos indígenas entre el estado mexicano de Oaxaca y California que han sido estudiadas durante mucho tiempo por Michael Kearney y sus colaboradores. En años recientes aumentaron las migraciones de indígenas a Estados Unidos como resultado del Tratado de Libre Comercio de Norteamérica y los cambios en la legislación agraria en México, que han conducido a la creciente privatización de la tierra y los recursos naturales, al despojo del campesinado tradicional y a numerosos conflictos locales sobre tierras y recursos. El levantamiento zapatista generó el surgimiento de gran cantidad de organizaciones indígenas militantes, ahora también estimuladas por los cambios constitucionales que reconocen los derechos humanos de los pueblos indígenas de acuerdo con las normas internacionales. Las migraciones indígenas transnacionales necesitan adaptarse a estas condiciones cambiantes.
The Strategic Integration of Latin America
Authors: Lo Brutto Giuseppe , Vázquez Salazar Carlos Otto 
Published: March 2015

The integration of Latin America and the Caribbean is a disputed process. In the new phase of integration represented by the Alianza Bolivariana para los Pueblos de Nuestra América and the Unión de Naciones Suramericanas, the control of natural resources has acquired central importance in a global scenario characterized by hegemonic reconfiguration and a tendency toward the creation of a multipolar world. For the integration to be viable, it must overcome the extractivist model and establish new forms of state-society relations. La integración de América Latina y el Caribe es un proceso disputado. En la nueva fase de integración representada por la Alianza Bolivariana para los Pueblos de Nuestra América y la Unión de Naciones Suramericanas, el control de los recursos naturales ha adquirido una importancia central en un escenario mundial caracterizado por la reconfiguración hegemónica y una tendencia a la creación de un mundo multipolar. Para que la integración sea viable debe poderse superar el modelo extractivista y se deben poder establecer nuevos tipos de relaciones entre Estado y sociedad.
An evaluation of the lower extremity muscle strength of patients with chronic venous insufficiency
Authors: Cetin Cem , Serbest Mustafa O , Ercan Sabriye , Yavuz Turhan , Erdogan Ali 
Published: March 2015

Objective In this study, the aim was to evaluate the lower extremity muscle strength in patients with chronic venous insufficiency using an isokinetic dynamometer. Methods The study comprised a group of 36 lower extremities of 23 patients diagnosed with chronic venous insufficiency and a control group of 40 lower extremities of 20 patients who did not have chronic venous insufficiency. In the diagnosis and evaluation of chronic venous insufficiency, photoplethysmography was used to evaluate the venous return circulation time. Visual Analog Scale scoring was applied to define the level of pain of the patients. Muscle strength measurements were made in all the lower extremities by using an isokinetic dynamometer. Results A statistically significant difference was detected between the groups in terms of the muscle strength parameters in the ankle plantar flexion, and knee flexor and extensor muscles. However, no statistically significant difference was found between the groups in the ankle dorsiflexion muscle strength parameters. A significant difference was determined in the ratio of ankle dorsiflexion/plantar flexion muscle strength between the mild, moderate and severe venous insufficiency groups. A statistically considerable negative correlation was found between the Visual Analog Scale scores and the photoplethysmography results. According to the Visual Analog Scale results, as the degree of venous insufficiency increased, so did the level of pain. Conclusion Impaired lower extremity muscle strength was observed in chronic venous insufficiency patients. Although the current study was consistent with literature in respect of impaired calf muscle strength, this finding was also seen in the thigh muscles. Furthermore, we concluded that if venous insufficiency becomes more severe, impaired calf muscle strength becomes more evident.
A qualitative study exploring the benefits of hospital admissions from the perspectives of patients with palliative care needs
Authors: Robinson Jackie , Gott Merryn , Gardiner Clare , Ingleton Christine 
Published: March 2015

Background: The acute hospital plays a significant role in caring for people with a life-limiting illness. Most research to date has focused exclusively upon the negative aspects of hospitalisation. Currently, there is little known about the benefits of hospital admissions for patients with palliative care needs. Aim: The aim of this study was to explore the benefits of hospital admissions, from the perspectives of patients with palliative care needs. Design: A qualitative study design was adopted. Longitudinal, semi-structured, face-to-face interviews were used to elicit the views of patients admitted to hospital in one large urban acute hospital in New Zealand. Setting/participants: The study sample comprised 14 patients admitted to Auckland City Hospital between July 2013 and March 2014 who met one of the Gold Standard Framework Prognostic Indicators for palliative care need. Results: Through a process of thematic analysis, four themes were identified from the data: being cared for and feeling safe, receiving care to manage at home, relief for family and ‘feeling better and/or getting better’. The benefits of being in hospital were reported to extend beyond treatments received. Most participants reported their preference was to come to hospital even if they had been able to access the care they received in hospital at home. Conclusion: This research contributes to a greater understanding of the benefits associated with hospitalisation for patients with palliative care needs. The findings suggest that such benefits extend beyond the treatment patients receive and challenge current assumptions regarding the role of the acute hospital in palliative care.
Publication Rates of Podium Versus Poster Presentations at the American Orthopaedic Society for Sports Medicine Meetings
Authors: Kinsella Stuart D. , Menge Travis J. , Anderson Allen F. , Spindler Kurt P. 
Published: March 2015

Background: Presentations at scientific meetings are often used to influence clinical practice, yet many presentations are not ultimately published in peer-reviewed journals. Previously reported publication rates for orthopaedic specialties have varied from 34% to 52%. In addition, the publication rate of accepted abstracts is a strong indicator of meeting quality, and it has a potential effect on clinical practice. To date, no studies have investigated publication rates in the field of sports medicine, and specifically for abstracts presented at American Orthopaedic Society for Sports Medicine (AOSSM) meetings. Purpose: To determine the overall publication rate of abstracts presented at AOSSM annual meetings and whether there were differences in publication rates between poster and podium presentations. Study Design: Descriptive epidemiology study. Methods: A comprehensive search was performed using PubMed and Google Scholar for all published manuscripts pertaining to abstracts presented at the 2006 to 2010 AOSSM annual meetings. Abstracts were classified according to presentation type (podium, poster) and subsequently were categorized into subspecialty area and study design. For published abstracts, the journal and publication date were recorded. Results: A total of 1665 abstracts were submitted to AOSSM annual meetings from 2006 to 2010, with 444 abstracts accepted (26.7% overall acceptance rate); there were 277 podium presentations and 167 posters. Of these 444 abstracts, 298 (67.1%) were published within 3 years in peer-reviewed journals. The overall publication rates for podium and poster presentations were 73.3% and 56.9%, respectively. For the combined years of 2006 to 2010, podium presentations were 2.08 (95% CI, 1.39-3.11) times more likely to be published compared with poster presentations. Conclusion: The overall publication rate of abstracts presented at AOSSM annual meetings (67.1%) was much higher than that reported for other orthopaedic meetings (34%-52%), highlighting the overall educational value and information quality of AOSSM meetings. In addition, there was a significant difference in the overall publication rates for podium and poster presentations. These data suggest that the quality and type of poster and podium presentations may not be equal, and these potential differences should be kept in mind when considering changes in clinical practice according to type of meeting presentation. Furthermore, AOSSM annual meeting program planners should consider these results when investigating ways to further improve the quality of research presented.
Arthroscopy Skills Development With a Surgical Simulator
Authors: Rebolledo Brian J. , Hammann-Scala Jennifer , Leali Alejandro , Ranawat Anil S. 
Published: March 2015

Background: Surgical simulation has become increasingly relevant to orthopaedic surgery education and could translate to improved operating room proficiency in orthopaedic surgery trainees. Purpose: To compare the arthroscopic performance of junior orthopaedic surgery residents who received training with a knee and shoulder arthroscopy surgical simulator with those who received didactic training. Study Design: Controlled laboratory study. Methods: Fourteen junior orthopaedic surgery residents at a single institution were randomized to receive knee and shoulder arthroscopy training with a surgical simulator (n = 8) or didactic lectures with arthroscopy models (n = 6). After their respective training, performance in diagnostic knee and shoulder arthroscopy was assessed using a cadaveric model. Time to completion and assessment of arthroscopic handling using a subjective injury grading index (scale, 1-10) was then used to evaluate performance in final cadaveric testing. Results: Orthopaedic surgery residents who trained with a surgical simulator outperformed the didactic-trained residents in shoulder arthroscopy by time to completion (–35%; P = .02) and injury grading index (–35%; P = .01). In addition, a trend toward improved performance of knee arthroscopy by the simulator-trained group was found by time to completion (–36%; P = .09) and injury grading index ( P = .08). Conclusion: In this study, junior orthopaedic surgery residents who trained with a surgical simulator demonstrated improved arthroscopic performance in both knee and shoulder arthroscopy. However, future validation of surgical simulator training for orthopaedic surgery residents remains warranted. Clinical Relevance: Surgical skill development with an arthroscopy surgical simulator could translate to improved arthroscopy performance in the operating room.