bluuebunny/crossref_metadata_2025_split huggingface dataset:
Community-Led Action Research in Oncology: Pandemic-Appropriate Radiotherapy Innovations Evaluated (CLARO PARTE) for Latin America and the Caribbean Countries
Authors: Riano Ivy , Alas-Pineda César , Reyes Garcia Sarahi , Murillo Raúl , Gutiérrez-Delgado Francisco , Cazap Eduardo , Pais Viegas Celia Maria , Torre Marcela de la , Barahona Kaory C. , Sarria Gustavo J. , del Castillo Bahi Ramón , Luongo-Céspedes Álvaro , Ovalles Beatriz , Umaña Herrera Flory Vanessa , Sánchez Ricardo , McVorran Shauna , Williams Benjamin , Kascmar Joseph , Kennedy Linda S. , Lyons Kathleen D. , Bejarano Suyapa , Wong Sandra L. 
Published: August 2024

PURPOSE This study aimed to identify, evaluate, and rank suitable safety innovations developed during the COVID-19 pandemic in Latin American and Caribbean (LAC) radiation oncology centers. METHODS We conducted a multimodal participatory engagement collaboration with the Latin-American and Caribbean Society of Medical Oncology. The study consisted of four phases. Innovations were collected from a panel of radiotherapy experts representing a diverse group of 11 countries from LAC (Phase I). Next, a medical scientific team compared the innovations against international standards regarding their potential impact on risk of infection, clinical operation, and continuity of quality cancer care (Phase II). Their findings were supplied to the country representatives who rated the innovations for acceptability in their cancer centers (Phase III), resulting in a final report of the panel's recommendations (Phase IV). RESULTS A total of 81 innovations were reported by the country representatives and merged by the medical scientific team into 24 innovations that combined similar innovations. The 24 innovations were grouped into six categories including practices aimed at (1) reducing clinic crowding (n = 3), (2) increasing screening and vaccinations for COVID-19 disease (n = 5), (3) implementing social distancing (n = 6), (4) strengthening personal infection equipment and disinfection (n = 6), (5) avoiding delaying or shortening treatment protocols (n = 2), and (6) mixed procedures (n = 2). The medical scientific team found nearly all innovations were supported by international recommendations and rated as safe, efficient, and acceptable. CONCLUSION By using the lessons learned from the Community-Led Action Research in Oncology: Pandemic-Appropriate Radiotherapy Innovations Evaluated study, a manual of scalable practices in radiation oncology clinics may be developed to guide actions during future large-scale public health crises in low- and middle-income countries of LAC.
Performance of Low-Dose Immunotherapy and Standard-Dose Immunotherapy in Microsatellite Instability-High Metastatic Colorectal Cancer: Real-World Data (CLouD—High Study)
Authors: Trikha Mehak , Sarkar Laboni , Dhanawat Aditya , Syed Noorzia , Gujarathi Himanshu , Vora Manan , Sivakumar Raja A. Sree , Bhargava Prabhat , Ramaswamy Anant , Mandavkar Sarika , Saklani Avanish , Kaushal Rajiv Kumar , Bal Munita , Shetty Omshree , Yadav Subhash , Ostwal Vikas 
Published: August 2024

PURPOSE Standard-dose immune checkpoint inhibitors (SD-ICIs) are the standard of care as initial therapy in microsatellite instable-high (MSI-H) advanced/metastatic colorectal adenocarcinomas (mCRC), but there are preclinical data to suggest that low-dose ICIs (LD-ICI) might also have similar efficacy. MATERIALS AND METHODS A retrospective study of patients with MSI-H mCRC receiving ICIs between June 2017 and January 2023 was conducted. The primary end point of the study was 12-month progression-free survival (PFS), which was computed using the Kaplan-Meier method. RESULTS A total of 65 patients were available for analysis during the study period. Sixty patients (92%) received nivolumab, whereas the remaining received pembrolizumab. First-line ICIs were received by 18 patients (28%), whereas 47 patients (72%) received ICIs during later lines. Thirty patients (47%) received LD-ICIs (all received nivolumab), with the remaining receiving SD-ICIs (53%). At a median follow-up of 16.5 (95% CI, 11.8 to 21.2) months, median PFS was not reached in the entire cohort. The 12-month PFS rate in the LD-ICI cohort was 90%, whereas it was 75.8% in the SD-ICI cohort. There were no statistical differences in patients receiving ICIs as first-line therapy (12 months PFS—94.4%) or during later lines of therapy (12-month PFS—77.9%; P = .56). CONCLUSION ICIs in the current study show survivals which are similar to those seen in seminal trials in patients with MSI-H mCRC. Low-dose ICIs appear to work in MSI-H mCRC and should be explored prospectively in clinical trials. Patients with MSI-H status should be exposed to ICIs, whether initially or later during treatment, whenever feasible.
Minimally Destabilizing Corridor for Resection of Dumbbell Nerve Sheath Tumors: A Novel Surgical Technique
Authors: Maragkos Georgios A. , Kurker Kristina P. , Yun Jonathan , Yen Chun-Po , Asthagiri Ashok R. 
Published: August 2024

BACKGROUND AND OBJECTIVES:
Current surgical strategies for dumbbell nerve sheath tumors (DNSTs) with cord compression have primarily involved wide spinal exposures with total laminectomy and unilateral facetectomy, often leading to spinal destabilization and requiring fusion, or staged procedures separately addressing the intraspinal and extraforaminal tumor components. This study highlights technical nuances of a novel approach for DNST resection to minimize spinal destabilization and avoid fusion while facilitating safe, single-stage complete resection.

METHODS:
A retrospective chart review was conducted on patients undergoing DNST resection. Using unilateral subperiosteal dissection, hemilaminotomy and medial facetectomy procedures are performed. The extradural tumor component is resected, followed by internal decompression of the intradural tumor. A small horizontal incision at the origin of the nerve root sleeve releases the underlying dural stricture, facilitating delivery of the remaining intradural tumor and allowing section of the nerve root of origin. Ultrasonography confirms complete tumor resection and return of cord pulsation, and excludes intradural hemorrhagic complications. The dura is reconstructed using a dural substitute bolstered with fat graft and sealant.

RESULTS:
Twelve consecutive patients undergoing this approach from 2014 to 2021 were included. Mean patient age was 53.5 years, and 58.3% were male. Nine tumors were cervical and 3 were lumbar. Five patients presented with myelopathy, 4 with radiculopathy, and 4 with axial pain. Two cases had transient intraoperative neuromonitoring signal changes. Eleven tumors were diagnosed as schwannomas and 1 as neurofibroma. All patients had complete resection of the intraspinal component; 2 had far distal extraforaminal residual. No patient has had recurrence, progression of residual, or signs of spinal instability during follow-up (median 28.5 months, range 6-66 months).

CONCLUSION:
This study highlights technical considerations for DNST resection, focusing the approach at the center of the tumor, with minimal bone removal and ligamentous disruption. Intraoperative ultrasound is instrumental in the safety of this approach.
An atlas of Brachypodium distachyon lateral root development
Authors: de Jesus Vieira Teixeira Cristovāo , Bellande Kevin , van der Schuren Alja , O'Connor Devin , Hardtke Christian S. , Vermeer Joop E. M 
Published: August 2024

ABSTRACT
The root system of plants is a vital part for successful development and adaptation to different soil types and environments. A major determinant of the shape of a plant root system is the formation of lateral roots, allowing for expansion of the root system. Arabidopsis thaliana, with its simple root anatomy, has been extensively studied to reveal the genetic program underlying root branching. However, to get a more general understanding of lateral root development, comparative studies in species with a more complex root anatomy are required. Here, by combining optimized clearing methods and histology, we describe an atlas of lateral root development in Brachypodium distachyon, a wild, temperate grass species. We show that lateral roots initiate from enlarged phloem pole pericycle cells and that the overlying endodermis reactivates its cell cycle and eventually forms the root cap. In addition, auxin signaling reported by the DR5 reporter was not detected in the phloem pole pericycle cells or young primordia. In contrast, auxin signaling was activated in the overlying cortical cell layers, including the exodermis. Thus, Brachypodium is a valuable model to investigate how signaling pathways and cellular responses have been repurposed to facilitate lateral root organogenesis.
Uncovering developmental diversity in the field
Authors: Brown Federico D. , Ishengoma Edson , Mayer Georg , Pabón-Mora Natalia , Santos M. Emília , Sears Karen E. , de Sena Oliveira Ivo 
Published: August 2024

ABSTRACT
Many developmental biologists seldom leave the lab for research, relying instead on establishing colonies of traditional and emerging model systems. However, to fully understand the mechanisms and principles of development and evolution, including the role of ecology and the environment, it is important to study a diverse range of organisms in context. In this Perspective, we hear from five research teams from around the world about the importance and challenges of going into the field to study their organisms of interest. We also invite you to share your own fieldwork stories on the Node.
Barometric pressure decrease induces density-dependent changes in foraging behaviour in a parasitoid fly
Authors: Houchat Jean-Noël , Castelo Marcela K. , Crespo José E. 
Published: August 2024

ABSTRACT
Barometric pressure is an environmental factor involved in the modulation of a variety of activities in insects. Generally, a drop in barometric pressure precedes the arrival of weather conditions that can affect insect activities and life expectancy. We simulated different scenarios of pressure drop in a modified hermetic chamber and studied their influence on the host-seeking behaviour of the larvae of the robber fly Mallophora ruficauda using air stationary olfactometers. In addition, we studied whether larval density modulates orientation to the host under the same scenarios of pressure drop. We found that motivation to search for hosts is affected by the same slope of pressure drop in both low- and high-density larvae. However, larval density modulates the onset of the responses to pressure decrease, as low-density larvae stop searching for hosts more quickly than high-density larvae. This result reflects an avoidance strategy according to which low-density larvae would have a reduced host range and higher risk of mortality and fewer chances to find a suitable host under adverse pressure conditions. Low-density larvae, known to prefer healthy hosts, do not search for parasitized hosts under normal pressure conditions nor under a range of pressure drops, strongly suggesting that host selectivity is not modulated by barometric pressure. This study paves the way to a better understanding of the changes in crucial insect behaviours induced by weather conditions, and provides more knowledge about the risk factors likely to affect insect survival in the context of foraging ecology.
Born suckers: the cibarial pump of Philaenus spumarius scales across ontogeny to ensure functional equivalence
Authors: Bergman Elisabeth A. , Matthews Philip G. D. 
Published: August 2024

ABSTRACT
A select group of hemipterans within the suborder Auchenorrhyncha are the only animals that feed exclusively on xylem sap – a nutritionally poor liquid that exists under negative pressure within a plant's xylem vessels. To consume it, xylem-feeding bugs have evolved enlarged cibarial pumps capable of generating enormous negative pressures. A previous study examining the allometry of this feeding model suggested that small xylem feeders pay relatively higher energetic costs while feeding, favouring the evolution of larger-bodied species. However, this interspecific analysis only considered adult xylem-feeding insects and neglected the considerable intraspecific change in size that occurs across the insect's development. Here, we examine the changes in cibarial pump morphology and function that occur during the development of Philaenus spumarius, the common meadow spittlebug. We show that the cibarial pump scales largely as expected from isometry and that the maximum negative pressure is mass independent, indicating that size has no effect on the xylem-feeding capacity of juvenile spittlebugs. We conclude that a first instar nymph with a body mass 2% of the adult can still feed at the &gt;1 MPa tension present in a plant's xylem vessels without a substantial energetic disadvantage.
The Association of Established Primary Care with Postoperative Outcomes Among Medicare Patients with Digestive Tract Cancer
Authors: Katayama Erryk S. , Thammachack Razeen , Woldesenbet Selamawit , Khalil Mujtaba , Munir Muhammad Musaab , Tsilimigras Diamantis , Pawlik Timothy M. 
Published: August 2024

Abstract
Background
Primary care (PC) is essential to overall wellness and management of comorbidities. In turn, patients without adequate access to PC may face healthcare disparities. We sought to characterize the impact of established PC on postoperative outcomes among patients undergoing a surgical procedure for a digestive tract cancer.

Methods
Medicare beneficiaries with a diagnosis of hepatobiliary, pancreas, and colorectal cancer between 2005 and 2019 were identified within the Surveillance, Epidemiology, and End Results program and Medicare-linked database. Individuals who did versus did not have PC encounters within 1-year before surgery were identified. A postoperative textbook outcome (TO) was defined as the absence of complications, no prolonged hospital stay, no readmission within 90 days, and no mortality.

Results
Among 63,177 patients, 50,974 (80.7%) had at least one established PC visit before surgery. Patients with established PC were more likely to achieve TO (odds ratio [OR], 1.14; 95% confidence interval [CI], 1.09–1.19) with lower odds for complications (OR, 0.85; 95% CI, 0.72–0.89), extended hospital stay (OR, 0.86; 95% CI, 0.81–0.94), 90-day readmission (OR, 0.94; 95% CI, 0.90–0.99), and 90-day mortality (OR, 0.87; 95% CI, 0.79–0.96). In addition, patients with established PC had a 4.1% decrease in index costs and a 5.2% decrease in 1-year costs. Notably, patients who had one to five visits with their PC in the year before surgery had improved odds of TO (OR, 1.21; 95% CI, 1.16–1.27), whereas individuals with more than 10 visits had lower odds of a postoperative TO (OR, 0.91; 95% CI, 0.84–0.98).

Conclusion
Most Medicare beneficiaries with digestive tract cancer had established PC within the year before their surgery. Established PC was associated with a higher probability of achieving ideal outcomes and lower costs. In contrast, patients with more than 10 PC appointments, which was likely a surrogate of overall comorbidity burden, experienced no improvement in postoperative outcomes.
Developing Trusted Collaborative Relationships between Healthcare Providers and Exercise Professionals
Authors: Bantham Amy , Young Jeff , Kampert Matthew 
Published: August 2024

Apply It!
• Exercise professionals will see the importance of building a referral network and will take the outlined steps necessary to build one.
• Exercise professionals will recognize the importance of communication in building trusted collaborative relationships with healthcare providers and will put a plan in place to provide progress reports of outcomes back to providers to increase their buy-in to the referral system.
Making Exercise as Medicine a Clinical Reality
Authors: Wonders Karen Y. , Franklin Barry A. , Brown Sheryl 
Published: August 2024

Apply It!
• Emphasize the Prevalence of Chronic Conditions: 52% of U.S. adults suffer from at least one chronic condition, underscoring the widespread need for exercise intervention in managing these diseases.
• Advocate for Structured Exercise Programs: Stress the importance of structured exercise programs in managing chronic diseases, citing well-documented physical and mental health benefits associated with regular physical activity.
• Educate on Exercise Thresholds: Educate clients on the exercise thresholds recommended by the World Health Organization, emphasizing the need for at least 150 to 300 minutes of moderate-intensity physical activity per week, complemented by resistance training and a reduction in sedentary behaviors.
• Tailor Programs to Individual Readiness: Assess clients' readiness to change unhealthy lifestyle habits using models like the Transtheoretical Stages of Change Model, and tailor exercise prescriptions and counseling accordingly to increase the likelihood of successful behavior change.
Classification Modeling using Methods Cross Industry Standard Process for Data Mining to Improve Product Quality
Authors: Pratiwi Pravitasari Anjar , Saikhu Ahmad 
Published: August 2024

The purpose of this research is to develop a classification model and measure the effect of changes in production inputs on product quality at PT. XZY. This study uses an analytical method adopting the CRISP-DM framework (Cross Industry Standard Process for Data Mining). At the modeling stage, the development of a classification model framework is carried out using the method Random Forest and Logistic Regression. Research results show that by applying the technique oversampling k-Mean SMOTE produces a product classification model with better predictive performance. on models Random Forest with k- Mean SMOTE was able to increase the AUC value from 0.810 to 0.944, while in Logistic Regression there was an increase in the AUC value from 0.690 to 0.724. An increase in the AUC value shows that with k-Mean SMOTE is able to produce a model with very good sensitivity in predicting data classes with low false positive/negative rates. Changes in tow, adhesive, and triacetin materials have a significant effect on the quality of the resulting product. Based on the odds ratio respectively, using adhesive, triacetin, and tow materials with SA/TRIAL status creates a higher chance of producing a product that does not meet the company's quality standards.
Stakeholder Analysis and RFID Implementation Model for Vehicles Using Design Thinking
Authors: Emanuela Gledis , Windharto Agus 
Published: August 2024

In Indonesia, the number of motor vehicles in 2022 reached 152,001,696 units. However, the use of technology to monitor the condition of motor vehicles is not very popular yet. Some chips installed on vehicles only serve as monitors. Therefore, researchers are interested in analyzing RFID in motor vehicles when applied in Indonesia. Through this research, the researchers hope to identify the needs of the Indonesian population regarding the use of RFID chips in motor vehicles. The approach will involve interviewing individuals or parties with interests related to the utilization of RFID in motor vehicles. Additionally, the researchers aim to develop an RFID implementation model that can be used in Indonesia in the future. The methodology for this study is qualitative, employing the design thinking approach. Design thinking was chosen due to its four elements (people-centered, highly creative, hands-on, and iterative) that are user-oriented and promote innovation. It is hoped that through this research, stakeholders involved in RFID development can collaborate and integrate for the development and utilization of RFID in Indonesia.
Evaluation of The Utilization of Bela Procurement System on The Effectiveness and Efficiency of Goods/Services Procurement
Authors: Ratih N. P. Manissar Tri , Suryani Erma 
Published: August 2024

This study evaluates the Bela Procurement system's utilization and effectiveness in Badung Regency Government. Data collection methods include observation, documentation, and interviews with an inductive qualitative approach. Respondents are personnel from the Badung Regency Goods/Services Procurement Work Unit, Bela Procurement Merchant Admins, and MSMEs in the Bela Procurement application. Data analysis uses the ITIL v3 framework. Results show the system's effectiveness and efficiency with a value of 3, despite some external user-side obstacles. Bela Procurement shortened the average order to 5 days, reduced delivery delays to 8%, and increased user satisfaction to 8.3. Prior procurement efficiency ratio increased to 55%. Operational cost savings were 20%. 10 out of 17 features were used, with the rest unused due to not meeting user needs. The system positively contributed to efficiency, completion time, and data accuracy. Obstacles identified include user understanding, technical limitations, and MSME participation. To optimize system utilization, efforts include increasing user training and understanding, MSME participation, and technical updates based on user input
ONE-STAGE VERSUS TWO-STAGE REVISION HIP ARTHROPLASTY: CAN WE CONFIRM THE DATA FROM META-ANALYSIS IN REAL-WORLD REGISTRY DATA?
Authors: Becker L. , Resl M. , Wu Y. , Kirschbaum S. , Perka C. 
Published: August 2024

Studies and meta-analyses worldwide show an increased use of one-stage revisions for treating periprosthetic hip infections, often yielding comparable or better outcomes than two-stage revisions. However, it remains unclear if these successful results can be consistently achieved nationwide besides large centers.This observational cohort study used data from the German Arthroplasty Registry (EPRD) to compare the mortality and re-revision rates between one-stage (n=8183) and two-stage (n=657) first-time revision total hip arthroplasty (RTHA). Kaplan-Meier estimates were applied to evaluate the re-revision rate and cumulative mortality for RTHA.There was a significant difference in mortality between one-stage and two-stage RTHA (p=0.02). One-year post-surgery, the mortality rate was 9.4% for one-stage revisions and 5.5% for two-stage revisions. At the five-year follow-up, the mortality rate for one-stage revisions was 25.5%, compared to 20.0% for two-stage revisions. No significant differences (p=0.30) were found in re-revision rates between one-stage and two-stage revisions after one year (one-stage 16.5% vs. two-stage 13.5%) or five years (one-stage 21.6% vs. two-stage 20.8%). For multiple revisions, the mortality differences were even larger (p<0.001), with a one-year mortality rate of 12.8% for one-stage RTHA and 5.7% for two-stage RTHA.Despite the excellent results of one-stage RTHA in the literature from individual large centers, it shows a significantly higher mortality rate with equal re-revision rate compared to two-stage revision in the nationwide care besides large centers. Significant differences can already be seen within the first year, indicating an increased perioperative mortality for one-stage revision, which might be explained by longer surgery duration, blood-loss and patient selection or maybe a lack of experience concerning proper surgical debridement for one-stage revision. This illustrates the need to establish centers for joint-revision surgery that provide interdisciplinary care and high case numbers to improve perioperative outcomes.