bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pseudo-Newtonian Simulation of a Thin Accretion Disk Around a Reissner–Nordström Naked Singularity
Authors: Čemeljić Miljenko , Kluźniak Włodek , Mishra Ruchi , Wielgus Maciek 
Published: February 2025

Abstract
We present the first numerical simulations of a thin accretion disk around a Reissner–Nordström (RN) naked singularity (NkS; a charged point mass). The gravity of the RN NkS is modeled with a pseudo-Newtonian potential that reproduces exactly the radial dependence of the RN Keplerian orbital frequency; in particular, orbital angular velocity vanishes at the zero gravity radius and has a maximum at 4/3 of that radius. Angular momentum is transported outward by viscous stresses only outside the location of this maximum. Nonetheless, even at that radius, accretion proceeds at higher latitudes, the disk having thickened there owing to excess pressure. The accretion stops at a certain distance away from the singularity, with the material accumulating in a toroidal structure close to the zero-gravity sphere. The shape of the structure obtained in our simulations is reminiscent of fluid figures of equilibrium analytically derived in full general relativity for the RN singularity. The presence of a rotating ring, such as the one found in our simulations, could be an observational signature of an NkS. For charge-to-mass ratios close to but larger than unity, the inner edge of the quasi-toroidal inner accretion structure would be located well within the Schwarzschild marginally stable orbit (ISCO), and the maximum orbital frequency in thin accretion disks would be much higher than the Schwarzschild ISCO frequency.
The Error Estimation of Transverse Coronal Loop Oscillation Parameters Based on Least Chi-squares Fitting
Authors: Li Hongbo , Feng Hengqiang , Tian Zhanjun , Cai Qiangwei , Zhao Guoqing , Zhao Yan 
Published: February 2025

Abstract
Transverse oscillations of coronal loops not only influence coronal dynamics, but also provide a new perspective for coronal detection. To enhance their exploitation and utilization, accurately estimating the oscillation parameters is crucial. The least chi-squares fitting is a widely employed method for this estimation. However, due to the highly nonlinear nature of the fitting process, there is no established theory to provide the exact error of the fitted parameters. In this study, we systematically investigated the accuracy and precision of the fitted parameters of transverse coronal oscillations through a series of forward simulations. Our investigation indicates that the accuracy and precision of fitted oscillation parameters are influenced not only by the standard deviation of the measurement error, but also by the temporal resolution and the characteristics of the signal itself. Based on these findings, we conducted additional forward simulations to estimate the influences on the real observation examples. The results clearly show that (1) the fitted damping timescale should be overestimated in a significant number of transverse coronal loop oscillations, and (2) errors estimated by the general method may be biased. In response, we have developed a forward simulation-based schema to achieve a self-consistent error estimation for the fitted oscillation parameters. These contributions not only offer valuable insights into the error estimation of fitted transverse coronal oscillation parameters, but also establish a robust foundation for obtaining accurate and precise transverse oscillation parameters of the corona.
Effects of capecitabine chemotherapy on the expression of CASC18, CASC19, and CASC20 lncRNAs in patients with colorectal cancer and the HCT-116 colorectal cancer cell line
Authors: Chayd Nafea M. , Khalaj-Kondori Mohammad , Safaralizadeh Reza , Hosseinpour Feizi Mohammad Ali 
Published: February 2025

Background: Colorectal cancer (CRC) is the third leading cause of cancer-related deaths. Capecitabine is a key chemotherapy drug for colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) play a role in the pathogenic pathways associated with colorectal cancer. This investigation compared the expression patterns of CASC18, CASC19, and CASC20 in CRC patients before and after chemotherapy, as well as in healthy individuals. The effects of capecitabine on cell viability, apoptosis, cell cycle, and the expressions of CASC18, CASC19, and CASC20 were examined using HCT-116 cells.
Methods: CASC18, CASC19, and CASC20 expressions were assessed using qRT-PCR on patients’ and healthy tissues. Furthermore, the receiver operating characteristic (ROC) curve analysis was used to evaluate the prognostic and diagnostic value of CASC18, CASC19, and CASC20 in CRC. The MTT test was used to assess capecitabine’s cytotoxicity on the HCT-116 CRC cell line. Annexin-V/PI staining was used to examine apoptosis and cell cycle progression by flow cytometry. Gene expression differences between before and after capecitabine treatments were examined by qRT-PCR.
Results: Results showed that patients with colorectal cancer had lower levels of CASC18 but higher levels of CASC19 and CASC20 expression than the healthy group. Moreover, patients treated with capecitabine showed an increased CASC18 expression, while non-significant changes were observed in the expression of CASC19 and CASC20. The clinical factors were not associated with the expression of lncRNAsCASC18, CASC19, and CASC20. Furthermore, results indicated that CASC18, CASC19, and CASC20 are poor biomarkers for diagnosis of CRC. MTT analysis revealed a dose- and time-dependent cytotoxic effect for capecitabine on the HCT-116 cells. Capecitabine treatment led to the accumulation of the HCT-116 cells in the Sub-G1 phase, suggesting an apoptotic solid impact on the cells. Moreover, HCT-116 cells were arrested in the G2/M phases by capecitabine. Capecitabine also upregulated CASC18 expression in the HCT-116 cell line.
Conclusion: These results support the anticancer and cytotoxic effects of capecitabine and highlight its ability to increase CASC18 expression. Additionally, the findings indicate that CASC18, CASC19, and CASC20 are poor biomarkers for colorectal cancer (CRC) diagnosis.
Des Œillets lusotropicalistes ?
Authors: Cahen Michel 
Published: February 2025

Il est facile de constater que le lusotropicalisme a survécu à la Révolution des Œillets. Cela induit deux questions. Premièrement, les manifestations de lusotropicalisme ont-elles été nombreuses dans le cours même de la révolution, en particulier parmi les militaires ? Deuxièmement, est-ce à cause des caractéristiques propres à la révolution que le lusotropicalisme aurait si bien survécu ? Cet article cherche à répondre à ces questions en analysant des textes, des déclarations, des actes de responsables politiques et militaires portugais dans les années postérieures à la Révolution des Œillets, jusqu’en 2024. Il cherche ensuite le même genre de comportement pendant la révolution elle-même. La conclusion est mitigée : oui, il existe un lusotropicalisme systémique au Portugal mais cela ne veut pas dire qu’il soit hégémonique. Par ailleurs, il est difficile de distinguer le lusotropicalisme de la vieille idéologie impériale du Portugal.
Descolonização do Timor-Leste: desdobramentos da Revolução dos Cravos na colônia mais longínqua (1974-1975)
Authors: Paredes Marçal de Menezes , Magnus Bianca Obetine 
Published: February 2025

A Revolução dos Cravos não se resume ao cenário português. Há toda uma história global que se desdobra à montante e à jusante do golpe do 25 de Abril de 1974. A guerra anticolonial e os processos de independência e transferência de poder nas ex-colônias na África e na Ásia são apenas algumas facetas deste processo. O trabalho político diplomático dos movimentos de libertação neste processo é outro ponto de elevada importância. Este artigo dá particular atenção ao turbilhão político que emerge da Revolução dos Cravos, que possuiu fortes articulações no ambito global da Guerra Fria. Discute-se o caso do Timor-Leste, a mais longínqua colônia portuguesa no sudeste asiático, como um cenário de exemplo das influêcias políticas oriundas do contexto português. Este artigo coloca em perspectiva as redes e as conexões globais existentes no processo da Revolução dos Cravos e de descolonização do Timor-Leste entre 1974 e 1975.
Visions de l’animal chez Giacomo Leopardi
Authors: Pignataro Agnese 
Published: February 2025

Cet article vise à interroger les différentes visions de l’animal propre à Giacomo Leopardi. Il entend notamment approfondir la question de la condition commune entre les êtres humains et les animaux. La pensée de Leopardi pose d’abord un écart entre l’homme et l’animal qui explique tant le malheur du premier, éloigné de sa condition naturelle, que le bonheur dont jouit le second. Nous montrons qu’au fil de l’évolution du système philosophique de Leopardi, ce thème perd progressivement de son importance et donne le relais à l’idée d’un état de souffrance inhérent à tous les êtres sensibles, humains et non humains. Dans cette seconde vision de l’animal, celui‑ci est au même titre que l’homme la victime de la cruelle indifférence de la nature. L’œuvre de Leopardi présente de nombreux exemples de la précarité de la vie animale, notamment du fait de la prédation, un mal ordinaire nécessaire au fonctionnement du cycle naturel de production/destruction. Cette idée d’une communauté de destin entre les humains et les autres animaux trouve son développement ultime dans l’esquisse léopardienne d’une alliance zoo‑anthropologique, dont nous approfondissons les sources et l’interprétation.
Leopardi à l’heure de l’Anthropocène
Authors: Lanfranchi Stéphanie 
Published: February 2025

Poser la question de Leopardi à l’heure de l’Anthropocène, interroger la pertinence d’une relecture de son œuvre à l’aune d’un débat, d’événements et d’une terminologie qui lui sont largement postérieurs, entraîne, du point de vue critique, de réelles difficultés méthodologiques et herméneutiques. S’agit‑il d’une énième actualisation de l’œuvre de Leopardi, comme l’histoire de sa réception et de sa fortune n’a cessé de nous en offrir durant les deux derniers siècles ? Dans cette contribution, nous aborderons d’abord les écueils méthodologiques auxquels se confronte inéluctablement une éco‑critique de Leopardi qui chercherait en lui un précurseur ou un visionnaire des apories écologiques de notre siècle. Nous tenterons ensuite d’inscrire notre interrogation à l’intérieur d’un cadre culturel, idéologique et géologique, qui intègre les questionnements actuels autour de l’Anthropocène dans les temps longs de l’histoire européenne occidentale, remontant jusqu’aux Lumières et à la révolution industrielle. Plutôt que d’actualiser la pensée de Leopardi, nous proposons ainsi une distant reading, diachronique et panoramique, susceptible d’historiciser le discours de l’Anthropocène en retraçant ses origines, pour voir dans quelle mesure Leopardi avait quelque chose à dire, dès le xixe siècle, sur et contre les mythes fondateurs de cet Anthropocène qui ne portait pas encore son nom.
Cartographies of difference: Race, gender and dis-eased humanity in Mphuthumi Ntabeni’s The Wanderers
Authors: Mavengano Esther 
Published: February 2025

The treatment of space in Mphuthumi Ntabeni’s novel The Wanderers provides important prisms through which the interlocking issues of race, gender and human frailties can be investigated. In this study, I bring together Michel Foucault and Doreen Massey’s perceptive formulations of spatiality and power to interrogate how Ntabeni’s representation of space intersects with the troubling tropes of racialised, gendered and dis-eased bodies in post-apartheid South Africa. I argue that the analogues of the frail human body and sickness are compelling symbolic figurations of dis-eased and broken people in South Africa’s post-apartheid literary narrative. The disquieting imageries are also extended to reflect teething challenges faced by Africa’s post-colonies in general. The novel’s portrayal of segregated bodies is entwined with spatial dimensions of power that influence characters’ sense of exclusion and fragility. This study explores and illustrates the various ways in which spatial landscapes are mapped to function as Foucault’s heterotopias – sites of both control and agency. Together, the allegories of pandemics and the frail body in The Wanderers create a striking portrayal of societal dis-ease – underlining the excruciating effects of historic and modern-day malaises and injustices. Lastly, this study contends that Ntabeni’s novel does not only analyse historical and existing power structures, but it also envisions alternative ways of promoting mutual well-being and recovery from past wounds in the current era.Contribution: Mphuthumi Ntabeni’s novel, The Wanderers is yet to receive ample scholarly attention, and this study intends to stimulate such interest in the context of both post-apartheid literature and transnational African literature. Bringing together Foucault and Massey’s theorisation of space and power in reading race, gender and politics of difference, it is intended to offer a refreshing interpretation concerning the human condition as portrayed in the text.
Endometriosis Quality of Life Cohort Study: Long-term Impact of Radical Laparoscopic Excision of Endometriosis
Authors: McDonnell Rose , Gollow Jessica , Nathan Elizabeth , Doherty Dorota , Majumder Kingshuk , Wilkinson Eden , McElhinney Bernadette , Karthigasu Krishnan , Hart Roger 
Published: February 2025

Abstract

Objectives:
The objectives of this study were to determine if radical laparoscopic excision of endometriosis (RLEE) improves long-term outcomes in the quality of life (QOL) and symptomatology experienced by women with the disease. Secondary objectives include recurrence and reoperation rates and impact on fertility.

Materials and Methods:
Prospective observational cohort study Patients who underwent surgical management of histologically confirmed endometriosis completed pre- and postoperative QOL questionnaires.

Results:
Baseline preoperative scores on QOL questionnaires were lower than the population norms. Overall, 63.0% of patients improved their global health scores, and 57.5% of patients improved their health state scores from baseline to the most recent follow-up. On the Short Form-12 questionnaire, 63% of patients improved their physical and/or mental scores. Overall improvement was shown in Visual Analog Scale pain scores in menstrual pain (79.2% improved, median improvement 3, P < 0.001, n = 72), noncyclical pelvic pain (64.4% improved, median improvement 2, P < 0.001, n = 73), dyschezia (63.9% improved, median improvement 2, P < 0.001, n = 72), and dyspareunia (65.6% improved, median improvement 1, P = 0.002, n = 64 pairs). There was a significant reduction in discomfort 1–2 years after primary surgery among sexually active patients (n = 23, pre- vs. postmedian score 4 vs. 2, P = 0.005). Repeat surgery was required in 36% of patients and 77.1% of those wishing to, achieved a successful pregnancy.

Conclusion:
RLEE significantly improves global health scores, with this improvement lasting up to 10 years following index surgery. It is also suggested that this management option has the capability of improving fertility outcomes in women with endometriosis.
Successful Pregnancy after Fertility-sparing Surgery and Treatment for Metachronous Multiple Primary Malignancies — A Case Report
Authors: Mercado Mary Evangeline Villa , Huang Kuan-Gen , Lay Zin Mar , Huang Shih-Yin 
Published: February 2025

Abstract
The occurrence of metachronous multiple primary malignancies remains relatively rare; however, its incidence is notably rising. We present the case of a 25-year-old woman who underwent fertility-sparing surgery, followed by chemotherapy for ovarian yolk sac tumor. Three years later, the patient was diagnosed with a large B-cell lymphoma in the cecum. She underwent bowel surgery and received chemotherapy postoperatively. Despite her condition, she was able to conceive spontaneously and had a successful pregnancy after treatment. This report highlights the importance of considering fertility-preserving treatment strategies in young patients and the possibility of spontaneous conception and successful pregnancy even in patients diagnosed with metachronous multiple primary malignancies who underwent extensive surgical procedures and heavily treated with chemotherapy.
Patch Testing to Identify Allergens Causing Pigmented Contact Dermatitis: A Retrospective Study
Authors: Choubey Shini , Satish Nithya , Srinivas Chakravarthi R. , Begum Farheen 
Published: February 2025

Abstract

Background:
One of the prevalent dermatological conditions identified among Indian patients visiting dermatology clinics is pigmented contact dermatitis (PCD). The gold standard for diagnosing PCD is patch testing. The allergen that results in PCD and its clinico-demographic pattern could differ. Identifying the common allergens will help the clinician while treating cases with PCD.

Aim and Objective:
To determine the clinico-demographic distribution of PCD and to establish the common allergens that are responsible by patch testing.

Patients and Methods:
The study included 30 patients with PCD. All patient’s clinico-demographic profiles were recorded. The extended Indian Standard Series kit comprising of 56 antigens was used for patch testing in the outpatient department. In addition, patch testing was done with a few brands of kumkum, sacred ash, sandalwood paste, and patients own material where it was indicated. The patch test was performed and interpreted as recommended by the International Contact Dermatitis Research Group.

Results:
The male: female ratio was 1:1.7. In 21 patients (70%), face was the most common site of pigmentation. The most frequently related symptom was pruritus. Out of the 30 patients, the patch test was positive in 25 (83.3%) of the cases. Paraphenylenediamine (PPD) and fragrance mix were found to be the most common allergens in 7 (28%) and 6 (24%) patients, respectively. In 13 patients (52.2%), reaction was observed with two or more allergens.

Limitation:
The above study, followed by photo-patch testing, may have detected more allergens inducing PCD. The photo-patch test was not performed due to non-availability of allergens.

Conclusion:
PPD is the most common allergen implicated, followed by fragrances.
Pneumothorax as first presentation of ‘ABPA sans asthma’
Authors: Chopra Preeyati , Suares Rhea S. , Deshwal Rishabh , Garg Kranti 
Published: February 2025

ABSTRACT
In patients with severe asthma with allergic bronchopulmonary aspergillosis (ABPA), a variety of radiological manifestations are seen. Pleural involvement is rare, and a very few case reports of secondary spontaneous pneumothorax have been reported in the literature. Here, we report an even rarer case of secondary spontaneous pneumothorax in a patient of ABPA ‘without asthma’.
Risk Factors and Prevalence of Depression in Children with Paediatric Chronic Kidney Disease: A Prospective Observational Study from India
Authors: Bhatia Navin , Pandey Shalini , Agarwal Amit 
Published: February 2025

Abstract

Objective:
To analyse risk factors for depression in children with paediatric chronic kidney disease (CKD) visiting haemodialysis care unit of a tertiary care hospital in Delhi, India.

Materials and Methods:
A prospective observational study, in which the study subjects were recruited from patients availing the facility of a dialysis unit at a tertiary care centre of Delhi India. The authors recruited 50 subjects who met the inclusion criteria. Child Depression Inventory (CDI) questionnaire was administered to subjects in language which they could easily understand by use of pen and paper. CDI scores, corresponding age- and sex-specific T-scores, were obtained from the table provided in CDI. The main outcome measure was to identify subjects with depression and analyse their associated risk factors.

Results:
Thirty-five out of 50 of the study participants were screened positive for depression. A positive correlation of depression was seen with female sex (P = 0.005), height <3rd centile (P = 0.014), weight <10th centile (P = 0.017), hypertension (P = 0.009), associated illnesses (P = 0.043) and students of class 6th and 9th in this study group (P = 0.046 and 0.044, respectively).

Conclusion:
Routine screening for depression should be done in all children with CKD, especially those with female sex, associated illnesses and those faltering on growth centile. CDI scoring should be done and if detected should be treated in conjunction with the psychiatrist.
discovery of interior design education in Turkey
Authors: Faiz Büyükçam Serap , Eyüboğlu Hande 
Published: February 2025

In this study, it is aimed to reveal the development of the agenda by identifying the focal scales addressed in the doctoral and proficiency in art theses produced in the discipline of interior architecture in Turkey, to draw attention to the synergies between universities and to present a chronological perspective. The study was designed with the explanatory sequential mixed method, which enables to develop an in-depth understanding of the subject and then to strengthen this understanding by making some categorisations. In the study, statistical analyses and content analyses of 227 thesis studies were carried out. Postgraduate thesis studies produced in the field of interior architecture have increased rapidly in recent years, with design research, environmental behaviour research and building technology research being the most focused topics. Design education, theoretical concepts, space perception and user-oriented design are of great interest to students. This study is limited to the doctoral and proficiency in art thesis studies in the discipline of interior architecture that have been successfully uploaded to the Council of Higher Education (YÖK) Thesis Centre, which regulates higher education activities in Turkey. This study, which provides a detailed overview of postgraduate studies, which are a resource in professional education where social benefit is prioritised, also reveals the limited limitlessness of professional practice and education. The study presents a comprehensive map of thesis studies in the field of interior architecture and is the first comprehensive research in this field in Turkey.
Risk based monitoring in clinical trial-a review
Authors: Rastogi Vishal , Vijayagiri Umasri , Manasa Aparna , V C.Randeep raj 
Published: February 2025

Risk based monitoring is the targeted approach in clinical trials for maintaining proper data integrity, protection of safety, rights of subjects and good of the trial subjects. The system of onsite monitoring by CRA was time uncontrollable and very effective. But now a day’s technology advancements and pandemic are encouraged to remotely collecting and imaging large data including data tracking site performance. Also enabling identification of trends, risk before selling the drug. The US FDA, proposed these approach of risk based monitoring (RBM). The drive to RBM at assiduity position started in August 2013. These review composition grounded on approach to RBM substantially concentrate on safety of subjects, quality of data and also for quickly and effectively mitigati.ng pitfalls before they compromise trial quality. These paper also provides the information regarding impact of covid19 in clinical trial monitoring and displacements of trial conditioning during the pandemic period. The pandemic situations forced companies to calculate substantially on remote and centralized monitoring due to point closures. The RBM geography check showed remote site monitoring increased and on site monitoring dropped at the peak of the pandemic in April compared with the pre-pandemic. These check also showed that chance of remote point observing visits increased from 18 in February to a high of 93 in April. The check concluded that RBM relinquishment before the COVID- 19 pandemic wasn't as wide as anticipated.