bluuebunny/crossref_metadata_2025_split huggingface dataset:
KERAGAMAN FENOTIPE DAN KARAKTERISASI SIFAT REPRODUKSI SAPI BALI (Bos sondaicus) BETINA PADA DUA KECAMATAN DI KABUPATEN BERAU
Authors: Supriadi Muhammad , Rahmatullah Surya Nur , Haris Muhammad Ichsan , Ibrahim Ibrahim , Suhardi Suhardi , Sulaiman Abrani 
Published: August 2024

Sapi Bali merupakan salah satu bangsa sapi lokal yang memiliki kemampuan dalam hal mengenal lingkungan yang baru dengan baik. Informasi keragaman dan penampilan reproduksi pada sapi Bali betina masih belum memiliki banyak informasi terkait karakterisasi dan penampilan reproduksi. Penelitian ini bertujuan untuk mengetahui keragaman fenotipe dan sifat reproduksi pada sapi Bali betina yang terdapat di kabupaten Berau, Kalimantan Timur. Penelitian ini dilaksanakan pada bulan Agustus – September 2020 di dua kecamatan, yaitu Kecamatan Sambaliung dan Talisayan, Kabupaten Berau. Penelitian menggunakan sapi Bali betina dengan umur 24-36 bulan. Data yang diambil dari pengukuran yang telah dilakukan kepada sapi Bali betina yang meliputi pengukuran tinggi pundak, panjang badan, dan lingkar dada serta kinerja reproduksi sapi Bali Betina. Data yang diperoleh dianalisis koefisien keragaman, regresi linear sederhana dan rataan dari kinerja reproduksi. Hasil penelitian menunjukan bahwa nilai keragaman dari tinggi pundak, panjang badan dan lingkar dada berturut-turut, 3,81%, 5,16% dan 4,02%. Panjang badan memiliki nilai keragaman yang paling tinggi dibandingkan sifat fenotipe lain yaitu lingkar dada dan tinggi Pundak sebesar 5,16%. Hasil analisis regresi menunjukan bahwa semua sifat fenotipe memiliki hasil yang signifikan (P<0,01) sehingga menunjukan perubahan sifat ukuran tubuh akan mempengaruhi pertambahan bobot badan. Berdasarkan sifat reproduksi, diketahui rata-rata umur pertama kali bunting pada sapi Bali betina yaitu 18,2 bulan, diketahui juga rata – rata umur pertama kali melahirkan yaitu 17,93 dan untuk berapa kali melahirkan di umur 2-3 tahun diketahui rata- rata 0,67. Hasil yang didapatkan menunjukan bahwa adanya keterkaitan antara kualitas fenotipe yang mempengaruhi penampilan reproduksi pada sapi Bali betina.
KANDUNGAN SELULOSA, HEMISELULOSA DAN LIGNIN SILASE PAKAN KOMPLIT BERBAHAN DASAR JERAMI JAGUNG (Zea mays) DENGAN PENAMBAHAN AZOLLA (Azolla pinnata) SEBAGAI PAKAN TERNAK RUMINANSIA
Authors: Alfiardi Muh. , Munir Munir , Rasbawati Rasbawati 
Published: August 2024

Tujuan penelitian ini untuk mengetahui kandungan selulosa, hemiselulosa dan lignin silase pakan komplit berbahan dasar jerami jagung (Zea mays) setelah penambahan azolla (Azolla pinnata) sebagai pakan ternak ruminansia. Penelitian silase pakan komplit menggunakan rancangan acak lengkap (RAL) dengan 4 perlakuan dan 3 ulangan. Adapun formulasi pakan komplit yang di terapkan pada penelitian ini adalah : S1= 50% Jerami Jagung+30% Azolla+19% Dedak Padi+1% Mineral Mix, S2= 50% Jerami Jagung+25% Azolla+24% Dedak Padi+1% Mineral Mix, S3= 50% Jerami Jagung+20% Azolla+29% Dedak Padi+1% Mineral Mix, S4= 50% Jerami Jagung+15% Azolla+34% Dedak Padi+1% Mineral Mix. Berdasarkan hasil yang diperoleh diketahui bahwa penambahan Azolla dapat mempengaruhi kandungan selulosa, hemiselulosa dan lignin pakan komplit. Adapun perlakuan terbaik yaitu pada perlakuan S1 dengan penambahan azolla sebanyak 30%.
Utilitarianisme Islam dan Risiko Pengaruhnya terhadap Shopee Buyer Satisfaction
Authors: Ummah Faza Faizatul , Aji Tony Seno , Sopingi Imam 
Published: August 2024

Tujuan penelitian ini untuk menilai sejauh mana pengaruh secara parsial dan simultan faktor utilitarianisme Islam dan risiko terhadap kepuasan pelanggan E-commerce Shopee oleh mahasiswa aktif FE UNHASY. Penelitian ini menerapkan metode asosiatif kausal. Teknik purposive sampling digunakan untuk memilih sampel penelitian ini. Sampel penelitian ini mahasiswa aktif dari Fakultas Ekonomi UNHASY dengan karakteristik yang melakukan pembelian online shopee pada tahun 2022 sampai 2023 yaitu sebanyak 70 responden. Analisis data menggunakan teknik regresi linear berganda. Hasil penelitian menunjukkan bahwa secara parsial utilitarianisme Islam memiliki pengaruh positif terhadap kepuasan pelanggan E-commerce Shopee. Sedangkan risiko berpengaruh negatif terhadap kepuasan pelanggan E-commerce Shopee. Utilitarianisme Islam dan risiko secara simultan berpengaruh terhadap tingkat kepuasan pelanggan E-commerce Shopee. Berdasarkan temuan penelitian ini diharapkan E-commerce Shopee dapat memperkokoh utilitarianisme Islam perusahaan, memperkuat manajemen risiko, dan kebijakan perusahaan yang tepat dan efisien perihal kepuasan pelanggannya.
Impact of different groups of pesticides on the population dynamic of honey bee (Apis melifera L.)
Authors: Parwaiz Gulkhanda , Ali Arif , Memon Shafique Ahmed , Mastoi Abdul Hafeez , Bugti Ghulam Ali , Arain Muhammad Shahid , Rajput Shahjahan , Roonjho Muhammad Afzal , Zaib Jahan , Yasir Changaiz 
Published: August 2024

Losses of honey bees and decline in bee colonies are becoming continuous threat to the apicultural industry, such as food security and environmental stability. Decline the population of honey bees in the field of agriculture, insecticides could be the possible factor for global colony losses. The aim of present research was to assess the impact of selected pesticides from different groups. Such as pyrethroid, organophosphate and botanical pesticides was used to compare with control group. Botanical extracts were used with 3 concentrations (5%, 10%, and 20%). The maximum mortality % of honey bees was observed on synthetic pesticides groups (organophosphate and pyrethroid), chlorpyrifos, trichlofon, and imidacloprid on (100%) after that profenofos treatment was associated with a high mortality rate (98.3%), Similarly pyrethroid group of pesticides lambda cyhalothrin (92%), clothianidin (87.3%), cypermethrin (80.3%) and bifenthrin (69.3%) as compared with control and botanical extracts. However on the plant base pesticides a maximum mortality % of honey bees was observed on Azadirachta indica 20% (17.6%) and stramonium leaves 20% (15%) as contrast with control group mortality rate (3.3%). Maximum repellency % of honey bees was observed on both (organophosphate and pyrethroid) groups of pesticides as compared with their respected control groups. While a less repellency % of honey bees was observed on all 3 concentrations of both botanicals plant based pesticides as compared with control. It is concluded that synthetic pesticides have lethal effects on the survival and repellency percentage of honey bees as compard with botanical pesticides.
Design and evaluation of a wedge-shaped adaptive knee orthosis for the human lower limbs
Authors: Zhou Xin , Liu Xiaoli , Hao Jiaxin , Liu Yu , Tang Yunqi 
Published: August 2024

IntroductionThe incidence of knee osteoarthritis (KOA) is moderately correlated with age and body weight and increases with life span and weight gain, associated with tearing and wearing the knee joints. KOA can adjust the force through the human lower limbs, redistribute the load of the knee joint, reduce the pain, and restore mobility when the arthritis changes are mild. However, most of the existing knee orthosis cannot be adjusted adaptively according to the needs of patients.MethodologyThis study establishes a biomechanical model of the knee joint to analyze the medial and lateral forces acting on the joint. The new adjustable knee orthosis is designed. It applies the principle of four-point bending to apply pressure to both sides of the knee joint, thereby adjusting the varus angle and modifying the medial and lateral forces on the knee joint. Through structural optimization, the prototype of the knee orthosis weighs only 324 g. Utilizing three-dimensional scanning technology, discrete point cloud data of the leg surface is obtained, reconstructed, and processed to create a 3D model of the human leg surface. The design ensures a close fit to the human leg surface, offering comfortable wear. A pressure sensing film system is employed to build a pressure sensing test system, where the knee orthosis is worn on a prosthesis for pressure testing to evaluate its ability to adjust knee joint forces.ResultsThe pressure test results demonstrate that the knee orthosis can stably provide an adjustment angle of 0–7° and sustain a maximum force of 10N on both sides of the knee joint over extended periods. A self-developed 8-channel plantar pressure sensing insole is calibrated against commercial plantar pressure sensors. Human wear tests on 15 subjects show that during the operation of the knee orthosis, it significantly adjusts plantar pressures, reducing lateral foot pressures by 22% overall, with more pronounced corrective effects observed in lighter participants.DiscussionIn this study, a wedge-shaped adaptive knee orthosis was provided for KOA patients. The four-point force principle was used to balance the force between femurs and tibia and adjust the meniscus contact gap. The orthotic appliance has the advantages of simple mechanical structure, adjustable correction Angle and good wearing comfort.
A single sequence MRI-based deep learning radiomics model in the diagnosis of early osteonecrosis of femoral head
Authors: Alkhatatbeh Tariq , Alkhatatbeh Ahmad , Li Xiaohui , Wang Wei 
Published: August 2024

PurposeThe objective of this study was to create and assess a Deep Learning-Based Radiomics model using a single sequence MRI that could accurately predict early Femoral Head Osteonecrosis (ONFH). This is the first time such a model was used for the diagnosis of early ONFH. Its simpler than the previously published multi-sequence MRI radiomics based method, and it implements Deep learning to improve on radiomics. It has the potential to be highly beneficial in the early stages of diagnosis and treatment planning.MethodsMRI scans from 150 patients in total (80 healthy, 70 necrotic) were used, and split into training and testing sets in a 7:3 ratio. Handcrafted as well as deep learning features were retrieved from Tesla 2 weighted (T2W1) MRI slices. After a rigorous selection process, these features were used to construct three models: a Radiomics-based (Rad-model), a Deep Learning-based (DL-model), and a Deep Learning-based Radiomics (DLR-model). The performance of these models in predicting early ONFH was evaluated by comparing them using the receiver operating characteristic (ROC) and decision curve analysis (DCA).Results1,197 handcrafted radiomics and 512 DL features were extracted then processed; after the final selection: 15 features were used for the Rad-model, 12 features for the DL-model, and only 9 features were selected for the DLR-model. The most effective algorithm that was used in all of the models was Logistic regression (LR). The Rad-model depicted good results outperforming the DL-model; AUC = 0.944 (95%CI, 0.862–1.000) and AUC = 0.930 (95%CI, 0.838–1.000) respectively. The DLR-model showed superior results to both Rad-model and the DL-model; AUC = 0.968 (95%CI, 0.909–1.000); and a sensitivity of 0.95 and specificity of 0.920. The DCA showed that DLR had a greater net clinical benefit in detecting early ONFH.ConclusionUsing a single sequence MRI scan, our work constructed and verified a Deep Learning-Based Radiomics Model for early ONFH diagnosis. This strategy outperformed a Deep learning technique based on Resnet18 and a model based on Radiomics. This straightforward method can offer essential diagnostic data promptly and enhance early therapy strategizing for individuals with ONFH, all while utilizing just one MRI sequence and a more standardized and objective interpretation of MRI images.
Is minimally invasive multi-vessel off-pump coronary surgery as safe and effective as MIDCAB?
Authors: Rufa Magdalena I. , Ursulescu Adrian , Dippon Juergen , Aktuerk Dincer , Nagib Ragi , Albert Marc , Franke Ulrich F. W. 
Published: August 2024

IntroductionThe safety and efficacy of minimally invasive direct coronary artery bypass (MIDCAB) surgery has been confirmed in numerous reports. However, minimally invasive multi-vessel off-pump coronary artery bypass grafting (MICS CABG) has lower uptake and has not yet gained widespread adoption. The study aimed to investigate the non-inferiority of MICS CABG to MIDCAB in long-term follow-up for several clinical outcomes, including angina pectoris, major adverse cardiac and cerebrovascular events (MACCE) and overall survival.MethodsThis is an observational, retrospective, single center study of 1,149 patients who underwent either MIDCAB (n = 626) or MICS CABG (n = 523) at our institution between 2007 and 2018. The left internal thoracic artery and portions of the radial artery and saphenous vein were used for the patients’ single-, double-, or triple-vessel revascularization procedures. We used gradient boosted propensity-score estimation to account for possible interactions between variables. After propensity-score adjustment, the two groups were similar in terms of preoperative demographics and risk profile. Long-term follow-up (mean 5.87, median 5.6 years) was available for 1,089 patients (94.8%).ResultsA total of 626, 454 and 69 patients underwent single, double and triple coronary revascularization, respectively. The long-term outcomes of freedom from angina pectoris, acute myocardial infarction, and revascularization rate were similar between the two groups. During follow-up, there were 123 deaths in the MIDCAB group and 96 in the MICS CABG group. The 1-, 3-, 5-, and 10-year survival rates were 97%, 92%, 85%, and 69% for the MIDCAB group and 97%, 93%, 89%, and 74% for the MICS CABG group, respectively. The hazard ratio of overall survival for patients with two or more bypass grafts compared to those with one bypass graft was 1.190 (p-value = 0.234, 95% CI: 0.893–1.586). This indicates that there was no significant difference in survival between the two groups. Furthermore, if we consider a hazard ratio of 1.2 to be clinically non-relevant, surgery with two or more grafts was significantly non-inferior to surgery with just one graft (p-value = 0.0057).ConclusionIn experienced hands, MICS CABG is a safe and effective procedure. Survival and durability are comparable with MIDCAB.
Prognostic value of right ventricular dysfunction in aortic regurgitation after transcatheter aortic valve replacement
Authors: Mao Yu , Liu Yang , Zhai Mengen , Jin Ping , Zhang Haibo , Wei Lai , Shang Xiaoke , Guo Yingqiang , Pan Xiangbin , Yang Jian 
Published: August 2024

BackgroundAortic regurgitation (AR) may lead to right ventricular dysfunction (RVD), but the prognostic value of RVD in patients undergoing transcatheter aortic valve replacement (TAVR) remains unclear. Our goal was to evaluate the clinical implications, predictors and prognostic significance of RVD in patients with pure AR after TAVR.MethodsIn this multicentre prospective study, patients undergoing TAVR were included between January 2019 and April 2021. The patients were divided into four groups according to the results of transthoracic echocardiography pre- and post-TAVR. The primary end point was 2-year all-cause mortality.ResultsA total of 648 patients were divided into four groups: 325 patients (54.3%) in the no RVD group; 106 patients (17.7%) in the new-onset RVD group; 73 patients (12.2%) in the normalized RVD group; and 94 patients (15.7%) in the residual RVD group. At the 2-year follow-up, there were significant differences in all-cause mortality among the four groups (5.2%, 12.3%, 11.0% and 17.0%, respectively; p &lt; 0.05). New-onset RVD was correlated with an increased risk of all-cause death and a composite end point and normalized RVD improved clinical outcomes of baseline RVD. Predictors of new-onset RVD included a higher Society of Thoracic Surgeons score, larger left ventricular end-diastolic volume, lower left ventricular ejection fraction, higher systolic pulmonary artery pressure and smaller RV base diameter.ConclusionsChanges in periprocedural RVD status significantly affect the risk stratification outcomes after TAVR. Therefore, they may be used as part of decision-making and risk assessment strategies.
Clinical Trial RegistrationClinicalTrials.gov Protocol Registration System (NCT02917980).
Neutrophil-to-lymphocyte ratio in type 2 diabetes patients combined with Lower Extremity Peripheral Artery Disease
Authors: Li Li , Wang Mengjie , Jia Ting , Jiang Xiaowan , Yang Fan , Wang Zhongjing , Zhang Xuyan 
Published: August 2024

ObjectiveThis study explored the utility of NLR (neutrophil-to-lymphocyte ratio) as a marker to predict Lower Extremity Peripheral Artery Disease (PAD) in the Chinese population, as well as to assess its consistency and diagnostic value with digital subtraction angiography.MethodsPatients were distributed into three groups according to the angiography in lower limb arterial: group L1, plaque with no stenosis; group L2, plaque with luminal stenosis and group L3, total vascular occlusion. Changes in the neutrophil-to-lymphocyte ratio were documented and compared among groups.ResultsCompared to group L1, NLR was significantly increased in L2 (1.76 vs 2.35, p=0.037) and L3 (1.76 vs 3.60, p&lt;0.001), with a gradual decrease in ABI (Ankle-Brachial Index, 1.11 vs 1.02 vs 0.94, p&lt;0.001). Those older patients with higher prevalence of hypertension (p=0.002), obesity (p=0.032), or reduced high-density lipoprotein cholesterol (p=0.020) were more likely to develop PAD; higher glycosylated hemoglobin (p=0.045), low-density lipoprotein cholesterol (p=0.006), and systolic blood pressure (p&lt;0.001) levels led to a greater tendency to suffer stenosis or even occlusion; the probability of severe stenosis (&gt;70%) increased to 2.075 times for every 1 increase in NLR, while it was 46.8% for every 0.1 increase in ABI. The optimal NLR cut-off value to predict severe stenosis in PAD was 2.73. Receiver operating characteristic curve analysis of the inflammatory biomarkers and severe stenosis prediction displayed an area under the curve of 0.81.ConclusionNLR could serve as a new noninvasive and accurate marker in predicting PAD.
Case report: Characterizing of free-floating pigmented vitreous cyst using swept-source optical coherence tomography
Authors: Shi Kexin , Yin Qichuan , Huang Yuxin , Zheng Sifan , Wang Yao , Shentu Xingchao 
Published: August 2024

AimA free-floating vitreous cyst is a rare eye disease. This study aimed to find diagnostic imaging methods and imaging features for vitreous cysts.MethodsThis article presents a case report along with a literature review of published cases of vitreous cysts. The case report describes a highly myopic 60-year-old woman with a pigmented, free-floating vitreous cyst in her right eye. A search of the PubMed database using the keywords “vitreous cyst” was performed to identify other cases reported in the literature and to summarize the imaging methods used to diagnose and visualize vitreous cysts and the imaging features of vitreous cysts.ResultsA thorough ophthalmic examination was performed in the present case, including slit-lamp photography, B-scan ultrasound, broad line fundus imaging, spectral-domain optical coherence tomography (SD-OCT), and ultra-wide field SS-OCT. The literature review revealed the imaging methods used in previously reported cases of vitreous cysts in which ultra-wide field SS-OCT has the advantages of wide scanning depth and high imaging clarity.ConclusionSS-OCT has an advantage over SD-OCT in providing intuitive morphological characteristic images for the diagnosis of posterior vitreous cysts. The comprehensive assessment of multimodal imaging examinations, including SS-OCT, is of significant value for the diagnosis and differential diagnosis of vitreous cysts.
Transcriptome-based identification of key actin-binding proteins associated with high metastatic potential in breast cancer
Authors: Müller Christian , Oliveira-Ferrer Leticia , Müller Volkmar , Schmalfeldt Barbara , Windhorst Sabine 
Published: August 2024

IntroductionActin-binding proteins (ABPs) are essential for the regulation of morphological plasticity required for tumor cells to metastasize. The aim of this study was to perform an unbiased bioinformatic approach to identify the key ABPs significantly associated with the metastatic potential of breast cancer cells.MethodsMicroarray data from 181 primary breast cancer samples from our hospital were used, and all genes belonging to the Gene Ontology term actin cytoskeleton organization were obtained from QuickGO. Association with metastasis-free survival probability was tested using Cox proportional hazards regression, and pairwise co-expression was tested by Pearson correlations. Differential expression between different subgroups was analyzed using Wilcoxon tests for dichotomous traits and Kruskal–Wallis tests for categorical traits. Validation was performed using four publicly available breast cancer datasets.ResultsARHGAP25 was significantly associated with a low metastatic potential, and CFL1, TMSB15A, and ACTL8 were significantly associated with a high metastatic potential. A significantly higher expression of CFL1, TMSB15A, and ACTL8 mRNA was found in the more aggressive Her2-positive and triple-negative subtypes as well as in ER-negative samples. Also, these genes were co-expressed in the same tumors. However, only mRNA levels of CFL1 were increased in pN1 compared to pN0 patients. External validation revealed that CFL1 and TMSB15A had significant associations with consistent hazard ratios in two breast cancer cohorts, and among these, CFL1 exhibited the highest hazard ratios.ConclusionCFL1 showed the strongest correlation with the metastatic potential of breast tumors. Thus, targeted inhibition of CFL1 might be a promising approach to treat malignant breast cancer cells.
An overview of systematic reviews of acupuncture for Parkinson’s disease
Authors: Xue Hua , He Hong-xian , Wu Dan , Fan Wen-hui , Li Ya-xin 
Published: August 2024

BackgroundMany systematic reviews (SRs) have reported the efficacy of acupuncture in improving Parkinson’s disease (PD), but the quality of evidence is unknown. Therefore, it is necessary to comprehensively summarize and objectively evaluate the evidence of acupuncture for PD.MethodsSeven databases were searched to retrieve SRs on the acupuncture for PD. Two reviewers independently completed literature retrieval, screening, and data extraction. The methodological quality, risk of bias (RoB), evidence quality of the included SRs were assessed by the Assessing the Methodological Quality of Systematic Reviews 2 (AMSTAR 2), the Risk of Bias in Systematic Reviews (ROBIS), the Grading of Recommendations Assessment, Development and Evaluation (GRADE) tool.ResultsA total of 24 SRs were included. According to AMSTAR 2, 6 (25%) were rated as high quality, 6 (25%) were rated as moderate quality, and 12 (50%) were rated as very low quality. The application of the ROBIS tool showed that 12 (25%) SRs were at low risk of bias. The results of GRADE showed that 8 (7.62%) outcomes provided high quality evidence, 23 (21.9%) outcomes provided moderate quality evidence, 42 (40%) outcomes provided low quality evidence, and 32 (30.48%) outcomes provided very low quality evidence.ConclusionThe overview indicates that acupuncture shows promise as a treatment for PD, although the evidence is limited and inconclusive due to methodological flaws and the heterogeneity of existing studies. Future research should focus on fully reporting methodological details and following review guidelines to produce more reliable and consistent evidence on the effectiveness of acupuncture for PD.Systematic review registrationhttps://inplasy.com, identifier INPLASY202480049.