bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Profound personal and professional impacts’: A qualitative study of clinician experiences of a mental health disaster response to Australia's black summer bushfires
Authors: Thomas Margaret , Martin Elizabeth , Isobel Sophie 
Published: July 2024

AbstractObjectiveTo explore the experiences of clinician and management stakeholders involved in a rural/metropolitan collaborative mental health disaster response to the 2019–2020 Black Summer bushfires in the Snowy Valleys region of southern New South Wales (NSW), Australia.SettingA mental health and drug health service in the Snowy Valleys region of rural NSW in collaboration with a mental health service from metropolitan Sydney, NSW.ParticipantsMental health clinicians and managers from a rural health district (n = 6) and a metropolitan health district (n = 8) involved in a collaborative disaster response to the 2019–2020 Black Summer bushfire disaster in the Snowy Valleys region of southern NSW, Australia.DesignAn interpretive qualitative study design using semi‐structured individual interviews, with transcripts analysed using Reflexive Thematic Analysis.ResultsThematic findings on participant experiences are presented under three organising constructs of before (stepping up and jumping right in), during (finding a rhythm of working together), and after (profound personal and professional impacts) the mental health disaster response.ConclusionParticipant experiences had shared and distinct components before, during and after the mental health disaster response, culminating in profound personal and professional impacts. Findings highlight positive aspects and challenges for clinicians participating in a rural/metropolitan collaborative mental health disaster response. The findings of this study contribute new knowledge about experiences of mental health clinicians participating in a disaster response after bushfires, from dual perspectives of members of a bushfire‐affected community and those responding from outside a bushfire‐affected community, which may inform ongoing planning of responses to disaster in Australia.
Polarizing effects of the coronavirus pandemic on system justification: A natural experiment involving New York City college students
Authors: Rivera Pichardo Eduardo J. , Parihar Sushmeena A. , Jost John T. 
Published: July 2024

AbstractPrevious research suggests that societal threats often increase ideological support for the social system, but the attitudinal effects of COVID‐19 seem to have varied greatly. Here we present the results of a natural experiment involving New York City college students (Total N = 1300 observations). One group (n = 835) completed questionnaires before the onset of COVID‐19, while another completed them afterward (n = 465). Shortly after COVID (within 3 months of the outbreak), students scored higher on general system justification than before; this effect was driven by political conservatives. At the same time, students scored lower on economic system justification and right‐wing authoritarianism after COVID (vs. before); these effects emerged later (4–5 months after the outbreak) and were driven by liberals. A subsample completed the same questionnaires both before and after COVID‐19 (n = 107), enabling us to investigate intraindividual change. The within‐participants analysis revealed that students exhibited an increase in general system justification and a decrease in economic system justification, which was driven by those who exhibited a liberal shift. Together, these results indicate that the ideological effects of the pandemic and the governmental response to it were complex and polarizing, with liberals and conservatives moving in opposite directions at different times and on different attitudinal dimensions.
Mindfulness‐Oriented Recovery Enhancement: Implementing an evidence‐based intervention for chronic pain, opioid use, and opioid addiction in clinical settings
Authors: Garland Eric L. 
Published: July 2024

AbstractThe opioid crisis emerged in part due to the overprescribing of opioid analgesics for chronic pain. Although not the only source of the current epidemic of opioid use disorder (OUD), the prescription of opioids for chronic pain remains one vector for the development of opioid misuse and OUD. However, opioid tapering is not appropriate for all patients, and some patients may need to remain on opioid therapy for the long term. To reduce the risk of opioid‐related harm among people with chronic pain and to treat incipient or entrenched addictive behaviours, new interventions are needed. This review discusses the clinical outcomes, biobehavioural mechanisms and implementation considerations for a novel, evidence‐based intervention for chronic pain, opioid use and OUD called Mindfulness‐Oriented Recovery Enhancement (MORE). MORE unites complementary aspects of mindfulness training, cognitive behavioural therapy and principles from positive psychology to simultaneously address addictive behaviour, emotion dysregulation and chronic pain by targeting brain reward and stress systems. MORE has been tested in 13 completed randomized clinical trials, including over 1300 patients, and has demonstrated efficacy against a range of active control conditions for reducing opioid dosing, opioid misuse, illicit drug use, depression, post‐traumatic stress symptoms and chronic pain. Opportunities for implementing MORE include facilitating opioid tapering and promoting safe opioid use in primary care and specialty pain clinics, decreasing opioid misuse and enhancing medication‐assisted treatment for OUD. Given evidence of MORE's efficacy, it is now time to consider disseminating this evidence‐based treatment in the United States, the United Kingdom and worldwide.
Medicinal cannabis tea contains variable doses of cannabinoids and no terpenes
Authors: Sønderskov Marie Bach , Hasselstrøm Jørgen Bo , Bahij Rime , Andersen Charlotte Uggerhøj 
Published: July 2024

AbstractTea is a recommended way of administration of prescribed cannabis plant products in Denmark. We aimed to investigate the cannabinoid and terpene doses contained in different teas. We analysed tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), cannabidiol (CBD), cannabidiolic acid (CBDA), and terpene concentrations in three repeated preparations of each type of tea, and in plant material.In standard tea, concentrations of THC were [median (min‐max)] 9.5 (2.3–15), 19 (13–34), and 36 (26–57) μg/mL for products with a labelled content of 6.3%, 14%, and 22% total THC (THC + THCA), respectively. The CBD concentration in tea from a product labelled with 8% total CBD (CBD + CBDA) was 7.5 (1.9–10) μg/mL. Based on this, the recommended starting amount of 0.2 L of the different teas would contain between 0.46 and 11.3 mg THC, and 0.38 to 2.0 mg CBD. Adding creamer before, but not after boiling, increased the THC and CBD concentration 2.3–4.4 and 2.1‐fold, respectively. Terpenes were detected in plant material, but not in tea.The study elucidates THC and CBD doses in different teas, which may assist the clinician's choice of cannabis product. Moreover, it underscores the need for caution as administration as tea can result in exposure to different doses, even when the same cannabis product is used.
Peptide derived from plant defensins: A promising 68Ga radiolabelled agent for diagnostic of infection foci in PET
Authors: Osorio Jessica , Rosas Roberto Castro , Vega Mariana Barraco , Reyes Ana Laura , Paolino Andrea , Menéndez Florencia , Vega‐Teijido Mauricio , Savio Eduardo , Giglio Javier , Cecchetto Gianna , Terán Mariella 
Published: July 2024

AbstractThe development of new radiopharmaceuticals for the detection of hidden infection foci has great relevance for early detection and the selection of the correct treatment, particularly in immunosuppressed patients. In that sense, the labelling of antimicrobial peptides (AMPs) that are capable of binding specifically to the pathogenic microorganism which causes the infection, should provide a sufficiently specific agent, able to distinguish an infection from a sterile inflammation. Defensins are particularly interesting molecules with antimicrobial activity, the EcgDf1 defensin was identified from the genome of a Uruguayan native plant, Erythrina crista‐galli, the ‘Ceibo’ tree. Our group has previously reported a synthetic biologically active short analogue EcgDf21 (ERFTGGHCRGFRRRCFCTKHC) successfully labelled with 99mTc. Herein we present a shorter analogue which also preserves the γ‐core domain, as a pharmacophore for a potential infection detection agent. This peptide was derivatized with the bifunctional chelating agent 1,4,7‐triazacyclononane‐1,4,7‐triacetic acid (NOTA) through a lysine linker in the amino‐terminal group (NOTA‐KGHCRGFRRRC) and radiolabelled with 68Ga ([68Ga]Ga‐NOTA‐K‐EcgDf1(10)). The [68Ga]Ga‐NOTA‐K‐EcgDf1(10) labelling procedure rendered a product with high radiochemical purity and stability in the labelling milieu. The Log P value indicated that the complex has a hydrophilic behaviour, confirmed by the biodistribution profile. The [68Ga]Ga‐NOTA‐K‐EcgDf1(10) complex demonstrated specific binding to cultures of Candida albicans and Aspergillus niger. Its biodistribution showed renal elimination and low accumulation in the rest of the body. It was possible to successfully differentiate sterile inflammation from infection by PET images in nude mice with a target/non‐target ratio of 3.3 for C. albicans and 3.7 for A. niger, respectively.
A Diffusion Approach to Radiance Field Relighting using Multi‐Illumination Synthesis
Authors: Poirier‐Ginter Y. , Gauthier A. , Phillip J. , Lalonde J.‐F. , Drettakis G. 
Published: July 2024

AbstractRelighting radiance fields is severely underconstrained for multi‐view data, which is most often captured under a single illumination condition; It is especially hard for full scenes containing multiple objects. We introduce a method to create relightable radiance fields using such single‐illumination data by exploiting priors extracted from 2D image diffusion models. We first fine‐tune a 2D diffusion model on a multi‐illumination dataset conditioned by light direction, allowing us to augment a single‐illumination capture into a realistic – but possibly inconsistent – multi‐illumination dataset from directly defined light directions. We use this augmented data to create a relightable radiance field represented by 3D Gaussian splats. To allow direct control of light direction for low‐frequency lighting, we represent appearance with a multi‐layer perceptron parameterized on light direction. To enforce multi‐view consistency and overcome inaccuracies we optimize a per‐image auxiliary feature vector. We show results on synthetic and real multi‐view data under single illumination, demonstrating that our method successfully exploits 2D diffusion model priors to allow realistic 3D relighting for complete scenes.
Stereo‐consistent Screen Space Reflection
Authors: Wu X. , Xu Y. , Wang L. 
Published: July 2024

AbstractScreen Space Reflection (SSR) can reliably achieve highly efficient reflective effects, significantly enhancing users' sense of realism in real‐time applications. However, when directly applied to stereo rendering, popular SSR algorithms lead to inconsistencies due to the differing information between the left and right eyes. This inconsistency, invisible to human vision, results in visual discomfort. This paper analyzes and demonstrates how screen‐space geometries, fade boundaries, and reflection samples introduce inconsistent cues. Considering the complementary nature of screen information, we introduce a stereo‐aware SSR method to alleviate visual discomfort caused by screen space disparities. By contrasting our stereo‐aware SSR with conventional SSR and ray‐traced results, we showcase the effectiveness of our approach in mitigating the inconsistencies stemming from screen space differences while introducing affordable performance overhead for real‐time rendering.
Patterns of substance use recovery following residential treatment: A repeated measures latent profile analysis
Authors: Robinson Laura D. , Degan Tayla J. , Deane Frank P. , Kelly Peter J. 
Published: July 2024

AbstractIntroductionOngoing improvement to residential treatment for substance use disorders is critical as it typically targets people with the highest need. Assessing multiple recovery indicators, such as cravings and mental health, at intake and following discharge is important in evaluating treatment effectiveness. To refine services, research should explore whether there are subgroups of individuals with different patterns of recovery following treatment.MethodsParticipants (n = 554) were attending Australian Salvation Army residential treatment services for substance use issues. Data were collected by surveys at intake and 3‐month post‐discharge (‘early recovery’). Recovery indicators were cravings, confidence to resist substance use and the Depression, Anxiety and Stress Scale. Subgroups of individuals based on these recovery indicators (‘profiles’) were identified using repeated measures latent profile analysis.ResultsFive profiles were identified, three profiles improved over time (81.4%) and two (18.6%) deteriorated across all indicators. These two profiles had the poorest mental health and addiction scores at intake and reported shorter time in treatment compared to the three profiles showing improvement. There were no demographic or substance type differences between profiles.Discussion and ConclusionsBy considering initial severity and multiple recovery indicators at early recovery, this study suggests that individuals at‐risk of poor early recovery can be identified at intake. This opens opportunities for tailored treatment approaches to address both mental health and substance use, thereby potentially improving treatment outcomes and reducing the risk of relapse.
Validation of the conceptual framework and intervention scope of oral function rehabilitation exercise
Authors: Choi Yong‐Keum , Park Hyang‐Ah , Cha Eun‐Gyeong , Lee Yunhwan , Yun Ji‐Hye 
Published: July 2024

ObjectivesThis study used a Delphi survey to define the concept of oral function rehabilitation exercise (OFRE) based on the International Classification of Functioning, Disability, and Health (ICF) and to categorise intervention domains for community‐dwelling older adults.BackgroundWhile numerous studies have been conducted to improve oral function through exercise interventions, the conceptual definition of oral exercise remains unclear and there is a lack of systematic categorisation of oral exercise intervention domains.MethodsA preliminary model was developed based on the key findings of 19 papers selected from a prior systematic review. Its validity was confirmed through a Delphi survey conducted twice with eight expert panellists. Consensus was achieved by evaluating the validity of the OFRE conceptual framework, the accuracy of OFRE conceptual definitions, and intervention domains.ResultsThrough expert consensus, an ICF‐based OFRE conceptual framework was developed that includes 21 factors that affect the oral health status of the older adults. The OFRE intervention domain for improving the health status consisted of oral function rehabilitation warm‐up exercise, masticatory function exercise, swallowing function exercise, articulatory function exercise, salivary function exercise, and oral function rehabilitation cool‐down exercise, and 11 specific intervention methods were derived.ConclusionsThe OFRE intervention can be used for planning and applying successful interventions to improve oral function and life function of older adults.
Perceived organizational support for strengths use and its impact on nurses’ job performance: The mediating roles of control beliefs about stress and optimism
Authors: Bai Chengzhi , Bai Baoyu , Yang Jian , Zhou Suhua 
Published: July 2024

AbstractAimsThis study explores how perceived organizational support for strengths use influences nurses’ job performance, specifically examining the mediating effects of control beliefs about stress and optimism.BackgroundIdentifying factors that enhance job performance is crucial in the demanding field of nursing. Previous research has highlighted the positive impact of perceived organizational support for strengths use on job performance.MethodConducted between May and October 2023, this study involved 653 nurses from various hospital settings across three Chinese provinces. A combination of convenience and snowball sampling methods ensured a representative sample. Questionnaires distributed via an online platform measured variables including perceived organizational support for strengths use, control beliefs about stress, optimism, and job performance. Data analysis utilized SPSS‐25 and the PROCESS macro, with correlation and regression analyses examining the relationships between perceived organizational support for strengths use, control beliefs about stress, optimism, and job performance.ResultsPerceived organizational support for strengths use positively correlates with control beliefs about stress, optimism, and job performance. Control beliefs about stress and optimism serve as mediators in the relationship between perceived organizational support for strengths use and job performance, both independently and sequentially, with optimism being the more potent mediator.ConclusionsThis study demonstrates that control beliefs about stress and optimism independently and sequentially mediate the relationship between perceived organizational support for strengths use and job performance among nurses.Implications for nursing and health policyThis research underscores the importance of creating a work environment that leverages nurses’ strengths and fosters their ability to manage stress and maintain optimism in the face of workplace challenges. Such an environment can significantly enhance job performance and overall well‐being among nurses.
Overcoming flumatinib resistance in chronic myeloid leukaemia: Insights into cellular mechanisms and ivermectin's therapeutic potential
Authors: Huang Jixian , Xiao Jie , He Lifeng , Dai Wenjie , Xiao Jian , Li Yuquan , He Ying , Yu Liang 
Published: July 2024

AbstractChronic myeloid leukaemia (CML) is a haematological malignancy characterized by the constitutive tyrosine kinase activity of the BCR‐ABL1 fusion protein. Flumatinib, a second‐generation tyrosine kinase inhibitor, has exhibited superior clinical efficacy compared to its precursor, imatinib. However, with increased clinical use, resistance to flumatinib has emerged as a significant challenge. To investigate the mechanisms of flumatinib resistance in CML, we induced the human CML cell line K562 using a flumatinib concentration gradient method in vitro, successfully establishing a flumatinib‐resistant K562/FLM cell line. This cell line exhibited cross‐resistance to imatinib and doxorubicin, but remained sensitive to the antiparasitic agent ivermectin, which possesses antitumoural effects. Through cellular experimentation, we explored the resistance mechanisms, which indicated that K562/FLM cells evade flumatinib cytotoxicity by enhancing autophagy, increasing the expression of membrane transport proteins, particularly P‐glycoprotein, ABCC1 and ABCC4, as well as enhancing phosphorylation of p‐EGFR, p‐ERK and p‐STAT3 proteins. Moreover, it was found that ivermectin effectively suppressed the expression of autophagy and transport proteins in K562/FLM cells, reduced the activity of the aforementioned phosphoproteins, and promoted apoptotic cell death. Collectively, the increased autophagy, higher expression of drug‐efflux proteins and hyperactivation of the EGFR/ERK/STAT3 signalling pathway were identified as pivotal elements promoting resistance to flumatinib. The significant effects of ivermectin might offer a novel therapeutic strategy to overcome flumatinib resistance and optimize the treatment outcomes of CML.
Religious origins of nationalist movements: The experience of India and the Sudan
Authors: Moniruzzaman Md , Ahmed Abdel Rahman AbdelRahman , Fahmida Farzana Kazi , Mujahid Atiqur Rahman 
Published: July 2024

AbstractNationalism in Asia and Africa is generally understood as a modern secular movement for independence. However, this idea is contestable. Analysing nationalism in India and the Sudan, this paper argues that nationalist movements there actually had their origins in Islamic religious resistance against the British colonial rule preceding the development of secular nationalism. Depending on political development following the colonial advancement, the secular elite‐led nationalism also largely fostered religious communal nationalism in India and the Sudan. This substantiates the argument that religion never ceased to play the most central role in the nationalist movements in India and the Sudan. Following an inter‐continental approach to study nationalism, this article explores exclusively the connection between religion and the first ever generic nationalist movements in the context of colonialism in India and the Sudan.
Mechanical forces orchestrate the metabolism of the developing oilseed rape embryo
Authors: Rolletschek Hardy , Muszynska Aleksandra , Schwender Jörg , Radchuk Volodymyr , Heinemann Björn , Hilo Alexander , Plutenko Iaroslav , Keil Peter , Ortleb Stefan , Wagner Steffen , Kalms Laura , Gündel André , Shi Hai , Fuchs Jörg , Szymanski Jedrzej Jakub , Braun Hans‐Peter , Borisjuk Ljudmilla 
Published: July 2024

Summary

The initial free expansion of the embryo within a seed is at some point inhibited by its contact with the testa, resulting in its formation of folds and borders. Although less obvious, mechanical forces appear to trigger and accelerate seed maturation. However, the mechanistic basis for this effect remains unclear.

Manipulation of the mechanical constraints affecting either the in vivo or in vitro growth of oilseed rape embryos was combined with analytical approaches, including magnetic resonance imaging and computer graphic reconstruction, immunolabelling, flow cytometry, transcriptomic, proteomic, lipidomic and metabolomic profiling.

Our data implied that, in vivo, the imposition of mechanical restraints impeded the expansion of testa and endosperm, resulting in the embryo's deformation. An acceleration in embryonic development was implied by the cessation of cell proliferation and the stimulation of lipid and protein storage, characteristic of embryo maturation. The underlying molecular signature included elements of cell cycle control, reactive oxygen species metabolism and transcriptional reprogramming, along with allosteric control of glycolytic flux. Constricting the space allowed for the expansion of in vitro grown embryos induced a similar response.

The conclusion is that the imposition of mechanical constraints over the growth of the developing oilseed rape embryo provides an important trigger for its maturation.