bluuebunny/crossref_metadata_2025_split huggingface dataset:
RNF168 ubiquitylates 53BP1 and controls its response to DNA double-strand breaks
Authors: Bohgaki Miyuki , Bohgaki Toshiyuki , El Ghamrasni Samah , Srikumar Tharan , Maire Georges , Panier Stephanie , Fradet-Turcotte Amélie , Stewart Grant S. , Raught Brian , Hakem Anne , Hakem Razqallah 
Published: December 2013

Significance
DNA damage-repair mechanisms are highly regulated, and posttranslational modifications are one means of such regulation. p53-binding protein 1 (53BP1) is important for the response to DNA double-strand breaks (DSBs). Here we report that its functions are regulated by RING finger 168 (RNF168), a DNA DSB-signaling protein that is mutated in the human radiosensitivity, immunodeficiency, dysmorphic features, and learning difficulties syndrome. We show that before their localization to DNA DSBs, RNF168 interacts with 53BP1 and modifies it through the addition of a chain of ubiquitin-polypeptides. We also show that Lysine 1268 of 53BP1 is important for its ubiquitin modification by RNF168 and that loss of this modification impairs 53BP1 recruitment to sites of DNA damage and restrains its functions in the repair of DNA damage and maintenance of genomic stability.
Structural basis of reverse nucleotide polymerization
Authors: Nakamura Akiyoshi , Nemoto Taiki , Heinemann Ilka U. , Yamashita Keitaro , Sonoda Tomoyo , Komoda Keisuke , Tanaka Isao , Söll Dieter , Yao Min 
Published: December 2013

Significance
Template-dependent RNA and DNA polymerization is a vital reaction in the cell and is believed to occur exclusively in the forward direction (5′-3′), which poses significant challenges to the cell in, for example, lagging strand synthesis. Although cells are mostly limited to unidirectional polymerization, we find that reverse polymerization is structurally and chemically possible utilizing the same structural core, the conserved palm domain of canonical polymerases. The structure of a unique reverse nucleotide polymerase-tRNA complex revealed that the direction of polymerization is determined by the orientation of approach of the polynucleotide substrate. Phylogenetic analysis indicates that reverse nucleotide polymerization is a primordial activity of the polymerase family.
Detection of H i absorption in the dwarf galaxy Haro 11
Authors: MacHattie Jeremy A. , Irwin Judith A. , Madden Suzanne C. , Cormier Diane , Rémy-Ruyer Aurélie 
Published: December 2013

Abstract
We present the results of an analysis of archival 21 cm (H i) data of the blue compact dwarf galaxy Haro 11 (ESO 350-IG038). Observations were obtained at the Very Large Array, and the presence of a compact absorption feature near the optical centre of the galaxy has been detected. The central location of the absorption feature coincides with the centre of the continuum background of the galaxy, as well as with the location of knot B. The absorption feature yields an H i mass in the range of 3–10 × 108 M⊙, corresponding to spin temperatures from 91 K to 200 K, respectively. The absence of H i seen in emission places an upper limit of 1.7 × 109 M⊙ on the mass. To our knowledge this is the first example of a dwarf galaxy that shows H i absorption from its own background continuum. The continuum emission from the galaxy is also used to determine star formation rates, namely 6.85 ± 0.05 M⊙ yr−1 (for a stellar mass range of 5 M⊙ &lt; M &lt; 100 M⊙), or 32.8 ± 0.2 M⊙ yr−1 (for an extended range of 0.1 M⊙ &lt; M &lt; 100 M⊙).
From solar-like to antisolar differential rotation in cool stars
Authors: Gastine T. , Yadav R. K. , Morin J. , Reiners A. , Wicht J. 
Published: December 2013

Abstract
Stellar differential rotation can be separated into two main regimes: solar-like when the equator rotates faster than the poles and antisolar when the polar regions rotate faster than the equator. We investigate the transition between these two regimes with 3D numerical simulations of rotating spherical shells. We conduct a systematic parameter study which also includes models from different research groups. We find that the direction of the differential rotation is governed by the contribution of the Coriolis force in the force balance, independently of the model setup (presence of a magnetic field, thickness of the convective layer, density stratification). Rapidly rotating cases with a small Rossby number yield solar-like differential rotation, while weakly rotating models sustain antisolar differential rotation. Close to the transition, the two kinds of differential rotation are two possible bistable states. This study provides theoretical support for the existence of antisolar differential rotation in cool stars with large Rossby numbers.
Learning by leading
Authors: Jenner Mark , Barnes June , James Steve 
Published: December 2013

Purpose
– The purpose of this paper is to describe an innovative senior-level leadership development programme in housing association, East Thames Group, which was designed to build the capabilities needed to lead the organisation through a transformation in its culture and working practices. The programme engaged leaders in navigating and shaping culture change in East Thames and in so doing significantly enhanced their capacity for self-awareness, decision making and collaboration.

Design/methodology/approach
– The paper presents a descriptive narrative of the leadership development process from its inception in November 2011, through the experience of two cohorts comprising 40 senior managers during 2012, to the formal conclusion of the process in January 2013. The narrative employs a modified version of the hero's journey to describe the process of individual and organisational development during this period.

Findings
– The paper proposes an effective alternative to prescriptive, competency-based, leadership programmes which is grounded instead in a problem-solving approach where capacity-building results from participants acting on “wicked” organisational problems and learning by leading.

Research limitations/implications
– Learning by leading is a flexible, highly contextualised alternative to programmatic approaches to leadership development. The challenges faced by East Thames will be familiar to leaders in both public and private sectors. This methodology is relevant wherever the strategic goal is a dual transformation in organisation performance and leadership capacity.

Practical implications
– The paper includes a model of leadership development based on five stages of the hero's journey. These design principles translate into a structure – a container – where leaders can think, act and learn together in order to decide how and where to intervene in their situation to make a difference.

Originality/value
– The paper presents a rare longitudinal description of a senior level leadership development process which used a complex organisational problem as a vehicle for both leadership agency and leadership learning.
Sexual health interventions targeting Mexican migrants: a review
Authors: Frances Barnes Erin , Saraí Dominguez Alejandra , Jazmín González Isabel 
Published: December 2013

Purpose
– A systematic literature review was performed to better understand the health promotion interventions proposed within the academic literature that aim to reduce the spread of sexually transmitted disease (STD) among Mexican migrants.

Design/methodology/approach
– The systematic review performed in this paper aimed to answer the research question: What interventions have been proposed within the academic literature to reduce the incidence of STD among Mexican migrants? A five-step decision tree was developed to review the 5,121 generated from the initial query. The final data set included 384 articles, 19 of which focussed on the target population.

Findings
– Results of the systematic review reflected eight themes: cultural, attitudinal, and contextual considerations, behavior modification, demographic factors, education, community mobilization, and access to services. The majority of themes suggest that structural level change is needed.

Originality/value
– Research on Mexican migrants in the USA is scant. Oftentimes research studies focus on “Hispanics” as a unit, neglecting the uniqueness of each individual subgroup. This paper addresses this limitation by focussing on Mexican migrants, a rapidly growing US population.
Assessment measures of Health-Related Quality of Life (HRQoL) of migrants: a systematic review
Authors: Buchcik Johanna , Westenhoefer Joachim , R. Martin Colin 
Published: December 2013

Purpose
– Definition-problems concerning the terms “migrant” and “Health-Related Quality of Life” (HRQoL) have a negative impact on the operationalization and measurement of the multidimensional and subjective construct of HRQoL. The aims of this systematic literature review are to address the following questions: How can the instruments used within the research field “migration and HRQoL” be described or categorized? Which dimensions (psychological, physical and social) and associated sub-dimensions have been used concerning measuring HRQoL when measures are applied to migrants?

Design/methodology/approach
– A systematic review was conducted. Three databases (Medline, Embase and Cinahl) were systematically searched for the investigation on HRQoL of migrants. Articles written in English, German and Polish, published since 2003 and meeting other inclusion criteria, were included in the final analysis.

Findings
– In the first stage a total of 4,062 studies were identified. However, very few studies were found to focus on HRQoL among migrants. Finally, 28 studies were included in the analysis. The results confirm that the terms “migrant” and “Quality of Life” and “Health-Related Quality of Life” are neither congruently used nor defined, respectively, within these studies, which consequently impacts deleteriously on the application and measurement of the concept in these groups. The majority of the studies reported to measure HRQoL with a well-known and validated HRQoL instrument. The physical dimensions (symptoms/pain/vitality, energy/vitality/sleep and the objective/subjective health status) are predominantly represented in the reviewed literature. The psychological dimension mostly includes sub-dimensions such as psychological stress and depressive symptoms; the social dimension was predominantly considered as the sub-dimension social relationships/networking.

Originality/value
– This paper highlights profound issues in the accurate assessment of HRQoL in migrants. This may have a significant impact on delivery of appropriate evidenced-based care for migrants in need of healthcare intervention.
Herbage dry‐matter production and forage quality of three legumes and four non‐leguminous forbs grown in single‐species stands
Authors: Elgersma A. , Søegaard K. , Jensen S. K. 
Published: December 2013

AbstractAgronomic data on most broad‐leaved species of grasslands are scarce. The aim of this study was to obtain novel information on herbage DM yield and forage quality for several forb species, and on species differences and seasonal patterns across harvests and in successive years. Four non‐leguminous forbs [salad burnet (Sanguisorba minor), caraway (Carum carvi), chicory (Cichorium intybus) and ribwort plantain (Plantago lanceolata)] and three leguminous forbs [yellow sweet clover (Melilotus officinalis), lucerne (Medicago sativa) and birdsfoot trefoil (Lotus corniculatus)] and a perennial ryegrass–white clover mixture were investigated in a small‐plot cutting trial in Denmark during 2009 and 2010. Plots were harvested four times per year. On average, annual herbage yield was highest for lucerne (15·4 t DM) and grass–white clover (12·5 t DM ha−1), and lowest for salad burnet (4·6 t DM ha−1) and yellow sweet clover (3·9 t DM ha−1). Ribwort plantain and lucerne had the highest concentrations of acid detergent fibre (339 and 321 g kg−1 DM respectively) and lignin (78 and 67 g kg−1 DM respectively); contents in other species were similar to grass–white clover (275 and 49 g kg−1 DM respectively). No common feature was found within the functional groups of non‐leguminous forbs and leguminous forbs, other than higher crude protein contents (198–206 g kg−1 DM) in the legumes. DM yield and fibre content were lowest in October. Digestibility declined with higher temperature and increasing fibre content. Results are discussed in terms of the potential of forbs to contribute to forage resources in farming practice.
Devitrification and Phase Separation of Zinc Borosilicate Glasses in the Presence of MgO, P2O5, and ZrO2
Authors: Soleimanzade Mehdi , Eftekhari Yekta Bijan , Marghussian Vahak 
Published: December 2013

A base glass composition which undergoes phase separation was chosen in the system Na2O‐ZnO‐B2O3‐SiO2. Spontaneous and reheat‐treatment opal glasses were synthesized by addition of different amounts of oxides such as P2O5 and ZrO2. To clarify devitrification, visible spectroscopy was performed for all samples. Reheat‐treated samples showed Tyndall effect in low temperatures, while they were completely opacified after soaking in 800°C for 3 h. P2O5‐or ZrO2‐containing samples opacified spontaneously. The mechanism of opacification in glasses containing the MgO and ZrO2 was partial crystallization, while in the mechanism of P2O5‐bearing one was liquid–liquid phase separation.
Lymphoma‐associated skin cancer: incidence, natural history, and clinical management
Authors: Brewer Jerry D. , Habermann Thomas M. , Shanafelt Tait D. 
Published: December 2013

AbstractThe link between immunosuppression and skin cancer has been well described. The two most common situations involving immunosuppression‐associated skin cancer are solid organ transplantation and non‐Hodgkin lymphoma (NHL), including chronic lymphocytic leukemia (CLL). Patients with lymphoma are more likely to have development of a secondary malignancy, with skin cancer being the most common. The most common types of skin cancer in patients with NHL/CLL include melanoma, squamous cell carcinoma, basal cell carcinoma, and Merkel cell carcinoma. Many skin cancers demonstrate increased aggressiveness in patients with NHL/CLL and are associated with higher recurrence rates, increased regional metastasis, and death secondary to skin cancer metastases. This review delineates the current research regarding the relationship between NHL/CLL and cutaneous malignancy. Immunosuppressed patients with skin cancer should be treated promptly and aggressively to decrease recurrence and metastases. Regular skin self‐examinations, dermatologic examinations, sun‐protective habits, and education may prove beneficial in this high‐risk patient population.
Clinical effectiveness and safety of cetirizine versus rupatadine in chronic spontaneous urticaria: a randomized, double‐blind, 6‐week trial
Authors: Dakhale Ganesh N. , Shinde Abhijit T. , Mahatme Mohini S. , Hiware Sachin K. , Mishra Dharmendra B. , Mukhi Jayesh I. , Salve Anoop M. 
Published: December 2013

AbstractBackgroundUrticaria is a distressing condition associated with diverse clinical presentations. Chronic spontaneous urticaria (CsU) is characterized by wheals and angioedema. Its treatment requires an algorithmic approach to identify the optimum medication.ObjectivesCetirizine is commonly used in the treatment of urticaria. Rupatadine is a selective non‐sedating H1‐antihistamine approved for the treatment of CsU. This trial was conducted to ascertain whether the properties of rupatadine offer advantages over cetirizine.MethodsSeventy patients with CsU were enrolled. Parameters assessed included: (i) mean number of wheals (MNW); (ii) pruritus; (iii) mean total symptom score (MTSS); (iv) size of wheal; (v) interference of wheals with sleep; and (vi) sedation. Patients with CsU were divided randomly into two groups. Routine investigations were performed at baseline and at the end of the study.ResultsEvaluations of MTSS, MNW, and pruritus revealed statistically significant differences at week 3 compared with baseline in the cetirizine group. However, greater reductions in these parameters were obtained with rupatadine. In patients receiving rupatadine, reductions in the MNW, size of wheals, and intensity of erythema were also significant at six weeks (P < 0.001) and were significantly greater than those in the cetirizine group (P < 0.05).ConclusionsImprovements in MTSS, MNW, size of wheals, intensity of erythema, and differential eosinophil count imply that rupatadine is a particularly attractive therapeutic modality compared with cetirizine for the treatment of CsU.
Dermoscopic patterns of cutaneous melanoma metastases
Authors: Rubegni Pietro , Lamberti Arianna , Mandato Filomena , Perotti Roberto , Fimiani Michele 
Published: December 2013

AbstractIn 2–8% of patients with melanoma, the first clinical manifestation of the disease may be skin metastasis. In these cases, differential diagnosis with the primary melanoma, benign melanocytic lesions, and other malignant and benign skin growths is particularly challenging. For this reason, the dermatologist's approach to cutaneous metastases of malignant melanoma calls for knowledge of the great morphological variety of these lesions. Dermoscopic characteristics associated with CMMMs have not yet been codified. The aim of the present review is to provide additional information about dermoscopic aspects of these skin lesions.
Minimally invasive transcrestal sinus floor elevation with deproteinized bovine bone or β‐tricalcium phosphate: a multicenter, double‐blind, randomized, controlled clinical trial
Authors: Trombelli Leonardo , Franceschetti Giovanni , Stacchi Claudio , Minenna Luigi , Riccardi Orio , Di Raimondo Rosario , Rizzi Alessandro , Farina Roberto 
Published: December 2013

AbstractAimsTo evaluate the outcomes of transcrestal sinus floor elevation (tSFE) performed with a minimally invasive procedure (Smart Lift technique) combined with the additional use of deproteinized bovine bone mineral (DBBM) or β‐tricalcium phosphate (β‐TCP).MethodsIn a multicenter randomized controlled trial, 38 sites in 38 patients were treated with the Smart Lift technique in association with DBBM (n = 19) or β‐TCP (n = 19). The extent of the sinus lift (SL) and the height of the graft apical to the implant apex (aGH) were assessed on periapical radiographs taken immediately after surgery and at 6 months following surgery.Results(i) Substantial aGH and SL were observed immediately after surgery and at 6 months, with no significant differences between DBBM and β‐TCP groups; (ii) a significant graft remodelling was observed from post‐surgery to 6‐months in the β‐TCP group and (iii) limited incidence of complications as well as limited post‐operative pain and discomfort were associated with the use of both graft materials.ConclusionsThe Smart Lift technique in conjunction with the additional use of either DBBM or β‐TCP may provide a substantial elevation of the maxillary sinus floor along with limited post‐surgical complications and post‐operative pain/discomfort.
Antenatal calcium intake in Malaysia
Authors: Mahdy Zaleha Abdullah , Basri Hashimah , Md Isa Zaleha , Ahmad Shuhaila , Shamsuddin Khadijah , Mohd Amin Rahmah 
Published: December 2013

AbstractAimTo determine the adequacy of antenatal calcium intake in Malaysia, and the influencing factors.MethodsA cross‐sectional study was conducted among postnatal women who delivered in two tertiary hospitals. Data were collected from antenatal cards, hospital documents and diet recall on daily milk and calcium intake during pregnancy. SPSS version 19.0 was used for statistical analyses.ResultsA total of 150 women were studied. The total daily calcium intake was 834 ± 43 mg (mean ± standard error of the mean), but the calcium intake distribution curve was skewed to the right with a median intake of 725 mg daily. When calcium intake from milk and calcium supplements was excluded, the daily dietary calcium intake was only 478 ± 25 mg. Even with inclusion of milk and calcium supplements, more than a third (n = 55 or 36.7%) of the women consumed less than 600 mg calcium in their daily diet. The adequacy of daily calcium intake was not influenced by maternal age, ethnicity, income or maternal job or educational status as well as parity.ConclusionThe daily dietary calcium intake of the Malaysian antenatal population is far from adequate without the addition of calcium supplements and milk.
The cardiokine secreted Frizzled‐related protein 3, a modulator of Wnt signalling, in clinical and experimental heart failure
Authors: Askevold E. T. , Aukrust P. , Nymo S. H. , Lunde I. G. , Kaasbøll O. J. , Aakhus S. , Florholmen G. , Ohm I. K. , Strand M. E. , Attramadal H. , Fiane A. , Dahl C. P. , Finsen A. V. , Vinge L. E. , Christensen G. , Yndestad A. , Gullestad L. , Latini R. , Masson S. , Tavazzi L. ,   the GISSI‐HF Investigators, Ueland T. 
Published: December 2013

AbstractObjectivesExperimental studies have shown involvement of Wnt signalling in heart failure (HF). We hypothesized that secreted frizzled‐related protein 3 (sFRP3), a modulator of Wnt signalling, is related to the progression of HF.DesignCirculating sFRP3 was measured in 153 HF patients and compared with 25 healthy controls. The association of sFRP3 with mortality was evaluated in 1202 patients (GISSI‐HF trial). sFRP3 mRNA expression was assessed in failing human and murine left ventricles (LV), and cellular localization was determined after fractioning of myocardial tissue. In vitro studies were carried out in cardiac fibroblasts subjected to cyclic mechanical stretch.Results(i) Heart failure patients had significantly raised serum sFRP3 levels compared with controls, (ii) during a median follow‐up of 47 months, 315 patients died in the GISSI‐HF substudy. In univariable Cox regression, tertiles of baseline sFRP3 concentration were significantly associated with all‐cause and cardiovascular mortality. After adjustment for demographic and clinical variables, but not for CRP and NT‐proBNP, the associations with mortality remained significant for the third tertile (all‐cause, HR 1.45, P = 0.011; cardiovascular, HR 1.66, P = 0.003), (iii) sFRP3 mRNA expression was increased in failing human LV, with a decline following LV assist device therapy. LV from post‐MI mice showed an increased sFRP3 mRNA level, particularly in cardiac fibroblasts, and (iv) mechanical stretch enhanced sFRP3 expression and release in myocardial fibroblasts.ConclusionThere is an association between increased sFRP3 expression and adverse outcome in HF, suggesting that the failing myocardium itself contributes to an increase in circulating sFRP3.