bluuebunny/crossref_metadata_2025_split huggingface dataset:
Belinostat in Patients With Relapsed or Refractory Peripheral T-Cell Lymphoma: Results of the Pivotal Phase II BELIEF (CLN-19) Study
Authors: O'Connor Owen A. , Horwitz Steven , Masszi Tamás , Van Hoof Achiel , Brown Peter , Doorduijn Jeannette , Hess Georg , Jurczak Wojciech , Knoblauch Poul , Chawla Shanta , Bhat Gajanan , Choi Mi Rim , Walewski Jan , Savage Kerry , Foss Francine , Allen Lee F. , Shustov Andrei 
Published: June 2015

Purpose Peripheral T-cell lymphomas (PTCLs) represent a diverse group of non-Hodgkin lymphomas with a poor prognosis and no accepted standard of care for patients with relapsed or refractory disease. This study evaluated the efficacy and tolerability of belinostat, a novel histone deacetylase inhibitor, as a single agent in relapsed or refractory PTCL. Patients and Methods Patients with confirmed PTCL who experienced progression after ≥ one prior therapy received belinostat 1,000 mg/m2 as daily 30-minute infusions on days 1 to 5 every 21 days. Central assessment of response used International Working Group criteria. Primary end point was overall response rate. Secondary end points included duration of response (DoR) and progression-free and overall survival. Results A total of 129 patients were enrolled, with a median of two prior systemic therapies. Overall response rate in the 120 evaluable patients was 25.8% (31 of 120), including 13 complete (10.8%) and 18 partial responses (15%). Median DoR by International Working Group criteria was 13.6 months, with the longest ongoing patient at ≥ 36 months. Median progression-free and overall survival were 1.6 and 7.9 months, respectively. Twelve of the enrolled patients underwent stem-cell transplantation after belinostat monotherapy. The most common grade 3 to 4 adverse events were anemia (10.8%), thrombocytopenia (7%), dyspnea (6.2%), and neutropenia (6.2%). Conclusion Monotherapy with belinostat produced complete and durable responses with manageable toxicity in patients with relapsed or refractory PTCL across the major subtypes, irrespective of number or type of prior therapies. These results have led to US Food and Drug Administration approval of belinostat for this indication.
CRE: a cost effective and rapid approach for PCR-mediated concatenation of KRAS and EGFR exons
Authors: Ramteke Manoj P. , Patel Kuldeep J , Godbole Mukul , Vyas Maulik , Karve Kunal , Choughule Anuradha , Prabhash Kumar , Dutt Amit 
Published: June 2015

Molecular diagnostics has changed the way lung cancer patients are treated worldwide. Of several different testing methods available, PCR followed by directed sequencing and amplification refractory mutation system (ARMS) are the two most commonly used diagnostic methods worldwide to detect mutations at KRAS exon 2 and EGFR kinase domain exons 18-21 in lung cancer. Compared to ARMS, the PCR followed by directed sequencing approach is relatively inexpensive but more cumbersome to perform. Moreover, with a limiting amount of genomic DNA from clinical formalin-fixed, paraffin-embedded (FFPE) specimens or fine biopsies of lung tumors, multiple rounds of PCR and sequencing reactions often get challenging. Here, we report a novel and cost-effective single multiplex-PCR based method, CRE (for Co-amplification of five KRAS and EGFR exons), followed by concatenation of the PCR product as a single linear fragment for direct sequencing. CRE is a robust protocol that can be adapted for routine use in clinical diagnostics with reduced variability, cost and turnaround time requiring a minimal amount of template DNA extracted from FFPE or fresh frozen tumor samples. As a proof of principle, CRE is able to detect the activating EGFR L858R and T790M EGFR mutations in lung cancer cell line and primary tumors.
Lernen von Shoppingcentern
Authors: Korzer Tanja 
Published: June 2015

Zusammenfassung
Shoppingcenter stehen in der Kritik, die Einzelhandelslandschaft der Innenstädte in Bezug auf das Einzelhandelsangebot und die geschaffenen Raumsituationen (vor allem in der Mall) zu uniformieren. Doch was machen Projektentwickler und Betreiber von Shoppingcentern u. a. bei der strategischen und konzeptionellen Gestaltung (z. B. in Bezug auf Kundenansprache, Branchen- und Sortimentsmix) richtig? Was können die Akteure in Klein- und Mittelstädten von ihnen für die innerstädtische Einzelhandelsentwicklung in Klein- und Mittelstädten lernen? Denn die Umsetzung geschlossener Shoppingcenter-Komplexe ist in der meist kleinteiligen Einzelhandelslandschaft dieses Stadttypus nur selten möglich und wünschenswert. Hinzu kommt, dass eine große Anzahl von Klein-und Mittelstädten von Schrumpfungstendenzen betroffen ist bzw. zukünftig betroffen sein wird, was maßgeblich Einfluss auf die Entwicklungsperspektiven des innerstädtischen Einzelhandels hat.
Aus diesen Gründen sind alternative Lösungsansätze für die Zusammenarbeit von Akteuren der Stadtentwicklungsplanung sowie lokalen Einzelhändlern in Klein- und Mittelstädten gefragt. Vor diesem Hintergrund erfolgte basierend auf einer interdisziplinär angelegten Literatur- und Dokumentenanalyse, unterschiedlichen Sekundärdatenauswertungen und Primärdatenerhebungen die Identifizierung von Shoppingcenter-Erfolgsfaktoren. Deren inhaltliche Systematisierung führte im Weiteren zur Formulierung eines übertragbaren Zielkatalogs für die innerstädtische Einzelhandelsentwicklung in Klein- und Mittelstädten. Die Anwendung des Zielkatalogs und dessen Reflektion in der Praxis erfolgte in Torgau (Sachsen) und zeigte wesentliche exemplarische Handlungsdefizite auf.
Der folgende Beitrag umreißt in Kurzform die Ergebnisse der Dissertation zu diesem Thema, wobei es in diesem Beitrag vor allem darum geht, die Vorgehensweise bei der Übertragung von Shoppingcenter-Erfolgsfaktoren aus verschiedenen Fachperspektiven (Architektur, Betriebswirtschaft etc.) auf die Stadtentwicklungsplanung mit dem Fokus auf die Innenstädte von Klein- und Mittelstädten darzustellen.
Fifty Baha’i Principles of Unity: A Paradigm of Social Salvation
Authors: Buck Christopher 
Published: June 2015

Abstract
The Baha’i Faith, a young world religion, offers principles of unity – from family relations to international relations – as a paradigm for social salvation. These principles may be studied within the analytic prism of an ‘illness/cure’ approach to religious soteriologies – a conceptual model in the phenomenology of religions popularized by Stephen Prothero. World religions are systems of salvation, liberation or harmony. Their respective offers of salvation, liberation or harmony respond directly to the human predicament, as defined by each religion. If humanity is plagued by sin, then Christianity’s redemptive offer of salvation from sin makes perfect sense. Early Buddhism’s offer of liberation – from the fundamental problem of suffering – also fits perfectly in this model. In the Baha’i religion, the plight facing the world is profound estrangement at all levels of society. Therefore the social salvation that the Baha’i religion offers are precepts and practices that augment unity and harmony, as Baha’u’llah proclaims: ‘The distinguishing feature that marketh the pre-eminent character of this Supreme Revelation consisteth in that We have … blotted out from the pages of God’s holy Book whatsoever hath been the cause of strife, of malice and mischief amongst the children of men, and have … laid down the essential prerequisites of concord, of understanding, of complete and enduring unity’. After reviewing Raymond Piper’s typology, fifty (50) Baha’i principles of unity are enumerated and briefly described: types of unity propounded by Baha’u’llah in the Tablet of Unity (Lawḥ-i Ittiḥād); types of unity forecast by ‘Abdu’l-Baha in the ‘The Seven Candles of Unity’; and types of unity articulated by Shoghi Effendi – a splendid array of understudied elements of the Baha’i social gospel. Since the present study is a first extended survey – of the notion of unity vis-à-vis the Baha’i Faith, based squarely on authenticated primary sources – results are preliminary, not definitive.
Arminius Vámbéry and the Baha’i Faith
Authors: Sárközy Miklós 
Published: June 2015

Abstract
There has been much debate about the mysterious life and complexities of the world-famous scholar, explorer and orientalist Arminius Vámbéry (1832–1913). During his long life he outlived many political and religious events, which markedly influenced his own personality. His encounters with different religions and religious identities are one of the most peculiar signs of his career. A unique character who equally came into contact with Judaism, Christianity and Islam though regularly regarding himself as an atheist, Vámbéry finally declared himself a follower of the Baha’i Faith in the last weeks of his life. The aim of this paper is to throw light on Vámbéry’s contacts with Baha’is, his perceptions on this religion and the reasons that led him to fully embrace this faith at the end of his life.
Dialectic of embodiment: Mysticism, materiality and the performance of Sufism in China
Authors: Ha Guangtian 
Published: June 2015

Abstract
This article attempts to contribute to the study of religious – particularly Sufi Islamic – structuring of the body from two perspectives: on the one hand, it pays attention not merely to the disciplinary dimension of the Jahriyya Sufi training in northwest China, but also to the specific processes that build this training around the corporeal acts of ritual consumption. On the other hand, this article also examines how the structuring of embodiment specific to Jahriyya Sufism is intrinsically linked to a strongly eschatological conception of time that greatly intensifies the disciplinary power of training. Rather than reduce the question to one of ritual rigidity or nostalgia for spiritual grandeur lost to a past presumed to be perpetually unchanging, the article argues that the specifically Jahriyya eschatology, marked by the insistence upon the sealing of the sacred genealogy, dialectically sublimates sainthood, elevating it from the concrete and corporeal to the symbolic and sublime. This symbolization and sublimation is located at the centre of Jahriyya mysticism and forms the definitive drive that structures the pious Jahriyya body. Based upon this ethnographic discovery, this article challenges the current tendency in anthropological and religious studies of Sufism and Islam that locates the body completely within the space of ethical and performative practice. It argues that the dimension of the symbolic and the sublime, irreducible to the practical, bears its own specificity that demands our analytical attention.
TBX20 loss-of-function mutation associated with familial dilated cardiomyopathy
Authors: Zhao Cui-Mei , Bing-Sun  , Song Hao-Ming , Wang Juan , Xu Wen-Jun , Jiang Jin-Fa , Qiu Xing-Biao , Yuan Fang , Xu Jia-Hong , Yang Yi-Qing 
Published: June 2015

AbstractDilated cardiomyopathy (DCM) is a major cause of congestive heart failure, sudden cardiac death and cardiac transplantation. Aggregating evidence highlights the genetic origin of DCM. However, DCM is a genetically heterogeneous disorder, and the genetic components underlying DCM in most cases remain unknown.The coding regions and splicing junction sites of theA novel heterozygous TBX20 mutation, p.F256I, was identified in a family with DCM transmitted in an autosomal dominant fashion, which co-segregated with DCM in the family with complete penetrance. The missense mutation was absent in 600 control chromosomes and the altered amino acid was completely conserved evolutionarily among various species. Functional assays revealed that the mutant TBX20 had significantly diminished transcriptional activity. Furthermore, the mutation markedly reduced the synergistic activation of TBX20 with NKX2-5 or GATA4.This study links TBX20 loss-of-function mutation to idiopathic DCM in humans for the first time, providing novel insight into the molecular mechanism underpinning DCM.
Efficient bulk heterojunction photovoltaic devices based on modified PCBM
Authors: Sharma Shyam S. , Sharma Khushboo , Sharma G.D. 
Published: June 2015

AbstractOrganic bulk heterojunction solar cells are a promising candidate for low-cost next-generation photovoltaic systems. In bulk heterojunction polymer solar cells, conjugated polymers and fullerene derivatives [6,6]-phenyl-C61-butyric acid methyl ester (PCBM) function as the electron-donating and electron-accepting materials, respectively. In this paper, we report the photovoltaic response of the solution-processed bulk heterojunction (BHJ) solar cell based on poly (2-methoxy-5-(2-ethylhexyloxy)-1,4-phenylenevinylene) (MEH-PPV): modified PCBM (MPCBM) blend. The BHJ showed power conversion efficiency (PCE) up to 1.78%. The PCE has been further improved up to 1.95% after thermal annealing of the active layer. The increase in the PCE with the thermally annealed blend is mainly attributed to the improvement in incident photon to current efficiency (IPCE) and short circuit photocurrent (Jsc).
Acetylenic antifolates as anticancer agents
Authors: Önen Bayram Filiz Esra , Sipahi Hande , Akgün Hülya 
Published: June 2015

Abstract
Folates are crucial cofactors involved in the de novo generation of purine and deoxythymidine monophosphate, which are essential for DNA synthesis. Antifolates are structural analogues of folate derivatives that act as inhibitors of folate-dependent enzymes and constitute the oldest antimetabolite class of anticancer agents. This review focuses on antifolates with remarkable anticancer activities that include a terminal alkyne function in their molecular structure. The properties of CB3717, a tremendous inhibitor of thymidylate synthase, are described, and the development of raltitrexed and pralatrexate, a dihydrofolate reductase inhibitor approved by the U.S. Food and Drug Administration (FDA) as the first drug for the treatment of relapsed and refractory peripheral T cell lymphoma are presented.
On the role of the extracellular space on the holistic behavior of the brain
Authors: Marcoli Manuela , Agnati Luigi F. , Benedetti Francesco , Genedani Susanna , Guidolin Diego , Ferraro Luca , Maura Guido , Fuxe Kjell 
Published: June 2015

AbstractMultiple players are involved in the brain integrative action besides the classical neuronal and astrocyte networks. In the past, the concept of complex cellular networks has been introduced to indicate that all the cell types in the brain can play roles in its integrative action. Intercellular communication in the complex cellular networks depends not only on well-delimited communication channels (wiring transmission) but also on diffusion of signals in physically poorly delimited extracellular space pathways (volume transmission). Thus, the extracellular space and the extracellular matrix are the main players in the intercellular communication modes in the brain. Hence, the extracellular matrix is an ‘intelligent glue’ that fills the brain and, together with the extracellular space, contributes to the building-up of the complex cellular networks. In addition, the extracellular matrix is part of what has been defined as the global molecular network enmeshing the entire central nervous system, and plays important roles in synaptic contact homeostasis and plasticity. From these premises, a concept is introduced that the global molecular network, by enmeshing the central nervous system, contributes to the brain holistic behavior. Furthermore, it is suggested that plastic ‘brain compartments’ can be detected in the central nervous system based on the astrocyte three-dimensional tiling of the brain volume and on the existence of local differences in cell types and extracellular space fluid and extracellular matrix composition. The relevance of the present view for neuropsychiatry is discussed. A glossary box with terms and definitions is provided.
Synthesis, crystal structure and magnetism of Eu3Sc2O5Fe2As2
Authors: Hummel Franziska , Tegel Marcus , Gerke Birgit , Pöttgen Rainer , Johrendt Dirk 
Published: June 2015

Abstract
The iron arsenide Eu3Fe2O5Fe2As2 was synthesized at 1173–1373 K in a resistance furnace and characterized by X-ray powder diffraction with Rietveld analysis: Sr3Fe2O5Cu2S2 type, I4/mmm, a = 406.40(1) pm, c = 2646.9(1) pm. Layers of edge-sharing FeAs4/4 tetrahedra are separated by perovskite-like oxide blocks. No structural transition occurs in the temperature range from 10 to 300 K. Magnetic measurements have revealed Curie–Weiss behavior with an effective magnetic moment of 7.79 μ
B per europium atom in agreement with the theoretical value of 7.94 μ
B for Eu2+. A drop in the magnetic susceptibility at 5 K indicates possible antiferromagnetic ordering. 151Eu and 57Fe Mössbauer spectroscopic measurements have confirmed a beginning cooperative magnetic phenomenon by showing significantly broadened spectra at 4.8 K compared to those at 78 K.
Adolescent Health and Adult Education and Employment: A Systematic Review
Authors: Hale Daniel R. , Bevilacqua Leonardo , Viner Russell M. 
Published: June 2015

OBJECTIVE:
Poor health in adolescence has the potential to disrupt education and employment pathways. This study is the first systematic review of the literature examining education and employment outcomes in adulthood of poor adolescent mental and physical health.

METHODS:
We conducted searches using a standardized search protocol in 8 electronic databases: PsycINFO, Medline, Embase, ERIC, British Education Index, Australian Education Index, Social Sciences Citation Index, and CINAHL Plus. We identified studies that longitudinally compared adult education and employment outcomes of those with an adolescent chronic condition of clinical severity with healthy controls. We conducted meta-analyses using odds ratios (for dichotomous variables) and Cohen’s d (for continuous variables) as our main summary statistics.

RESULTS:
We identified 27 studies incorporating 70 relevant analyses. Our meta-analyses suggested that overall, poor health in adolescence was associated with poorer education and employment outcomes in adulthood. However, evidence was much stronger for mental health conditions than for physical health conditions, for which less evidence was available and mixed findings emerged. Compared with mental health conditions, we identified few studies investigating the long-term outcomes of physical health conditions. Age and follow-up times varied considerably across our studies, which potentially resulted in some heterogeneity in effect sizes. The majority of included studies were conducted in the United States, raising questions about the generalizability of the results internationally.

CONCLUSIONS:
Health in adolescence contributes to adult attainment and life chances. The results suggest that investment in health may improve life chances and that policy interventions may improve outcomes for those with adolescent chronic conditions.
Systematic Review on Intensive Interdisciplinary Pain Treatment of Children With Chronic Pain
Authors: Hechler Tanja , Kanstrup Marie , Holley Amy Lewandowski , Simons Laura E. , Wicksell Rikard , Hirschfeld Gerrit , Zernikow Boris 
Published: June 2015

BACKGROUND AND OBJECTIVE:
Pediatric debilitating chronic pain is a severe health problem, often requiring complex interventions such as intensive interdisciplinary pain treatment (IIPT). Research is lacking regarding the effectiveness of IIPT for children. The objective was to systematically review studies evaluating the effects of IIPT.

METHODS:
Cochrane, Medline/Ovid, PsycInfo/OVID, PubMed, PubPsych, and Web of Science were searched. Studies were included if (1) treatment was coordinated by ≥3 health professionals, (2) treatment occurred within an inpatient/day hospital setting, (3) patients were &lt;22 years, (4) patients experienced debilitating chronic pain, (5) the study was published in English, and (6) the study had ≥10 participants at posttreatment. The child’s pain condition, characteristics of the IIPT, and 5 outcome domains (pain intensity, disability, school functioning, anxiety, depressive symptoms) were extracted at baseline, posttreatment, and follow-up.

RESULTS:
One randomized controlled trial and 9 nonrandomized treatment studies were identified and a meta-analysis was conducted separately on pain intensity, disability, and depressive symptoms revealing positive treatment effects. At posttreatment, there were large improvements for disability, and small to moderate improvements for pain intensity and depressive symptoms. The positive effects were maintained at short-term follow-up. Findings demonstrated extreme heterogeneity.

CONCLUSIONS:
Effects in nonrandomized treatment studies cannot be attributed to IIPT alone. Because of substantial heterogeneity in measures for school functioning and anxiety, meta-analyses could not be computed. There is preliminary evidence for positive treatment effects of IIPT, but the small number of studies and their methodological weaknesses suggest a need for more research on IIPTs for children.
Critical Elements in the Medical Evaluation of Suspected Child Physical Abuse
Authors: Campbell Kristine A. , Olson Lenora M. , Keenan Heather T. 
Published: June 2015

BACKGROUND:Previous research has described variability in medical evaluation of suspected abuse. The objective of this study was to identify, through expert consensus, required and highly recommended elements of a child abuse pediatrics (CAP) evaluation for 3 common presentations of suspected physical abuse in children aged 0 to 60 months.METHODS:Twenty-eight CAPs recruited from 2 national organizations formed the expert panel for this modified Delphi Process. An initial survey was developed for each presentation based on demographics, history of present illness, past medical, family and social history, laboratory, radiology, and consultation elements present in at least 10% of CAP consultations collected for a larger study. CAPs ranked each element on a 9-point scale then reviewed and discussed summary results through a project blog over 3 rounds. Required and highly recommended elements were defined as elements ranked as 9 and 8, respectively, by ≥75% of experts after the final round.RESULTS:From 96 elements in the initial surveys, experts identified 30 Required elements and 37 Highly Recommended elements for CAP evaluation of intracranial hemorrhage, 21 Required and 33 Highly Recommended elements for CAP evaluation of long bone fracture, and 18 Required and 16 Highly Recommended elements for CAP evaluation of isolated skull fracture.CONCLUSIONS:This guideline reflects expert consensus and provides a starting point for development of child abuse assessment protocols for quality improvement or research. Additional research is required to determine whether this guideline can reduce variability and/or improve reliability in the evaluation and diagnosis of child physical abuse.