bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinome RNAi Screens Reveal Synergistic Targeting of MTOR and FGFR1 Pathways for Treatment of Lung Cancer and HNSCC
Authors: Singleton Katherine R. , Hinz Trista K. , Kleczko Emily K. , Marek Lindsay A. , Kwak Jeff , Harp Taylor , Kim Jihye , Tan Aik Choon , Heasley Lynn E. 
Published: September 2015

Abstract
The FGFR1 is a therapeutic target under investigation in multiple solid tumors and clinical trials of selective tyrosine kinase inhibitors (TKI) are underway. Treatment with a single TKI represents a logical step toward personalized cancer therapy, but intrinsic and acquired resistance mechanisms limit their long-term benefit. In this study, we deployed RNAi-based functional genomic screens to identify protein kinases controlling the intrinsic sensitivity of FGFR1-dependent lung cancer and head and neck squamous cell cancer (HNSCC) cells to ponatinib, a multikinase FGFR-active inhibitor. We identified and validated a synthetic lethal interaction between MTOR and ponatinib in non–small cell lung carcinoma cells. In addition, treatment with MTOR-targeting shRNAs and pharmacologic inhibitors revealed that MTOR is an essential protein kinase in other FGFR1-expressing cancer cells. The combination of FGFR inhibitors and MTOR or AKT inhibitors resulted in synergistic growth suppression in vitro. Notably, tumor xenografts generated from FGFR1-dependent lung cancer cells exhibited only modest sensitivity to monotherapy with the FGFR-specific TKI, AZD4547, but when combined with the MTOR inhibitor, AZD2014, significantly attenuated tumor growth and prolonged survival. Our findings support the existence of a signaling network wherein FGFR1-driven ERK and activated MTOR/AKT represent distinct arms required to induce full transformation. Furthermore, they suggest that clinical efficacy of treatments for FGFR1-driven lung cancers and HNSCC may be achieved by combining MTOR inhibitors and FGFR-specific TKIs. Cancer Res; 75(20); 4398–406. ©2015 AACR.
HMDB and 5-AzadC Combination Reverses Tumor Suppressor CCAAT/Enhancer-Binding Protein Delta to Strengthen the Death of Liver Cancer Cells
Authors: Li Chien-Feng , Tsai Hsin-Hwa , Ko Chiung-Yuan , Pan Yen-Chun , Yen Chia-Jui , Lai Hong-Yue , Yuh Chiou-Hwa , Wu Wan-Chen , Wang Ju-Ming 
Published: September 2015

Abstract
Hepatocellular carcinoma (HCC) can arise from chronic inflammation due to viral infection, organ damage, drug toxicity, or alcohol abuse. Moreover, gene desensitization via aberrant CpG island methylation is a frequent epigenetic defect in HCC. However, the details of how inflammation is linked with epigenetic-mediated desensitization of tumor suppressor genes remains less investigated. In this study, we found that loss of CEBPD enhances the growth of liver cancer cells and is associated with the occurrence of liver cancers, as determined by the assessment of clinical specimens and in vivo animal models. Moreover, E2F1-regulated epigenetic axis attenuated CEBPD expression in liver cancer cells. CEBPD is responsive to the hydroxymethyldibenzoylmethane (HMDB)-induced p38/CREB pathway and plays an important role in the HMDB-induced apoptosis of cancer cells. Regarding depression of epigenetic effects to enhance HMDB-induced CEBPD expression, the combination of HMDB and 5-Aza-2′-deoxycytidine (5-AzadC) could enhance the death of liver cancer cells and reduce the tumor formation of Huh7 xenograft mice. In conclusion, these results suggest that CEBPD could be a useful diagnostic marker and therapeutic target in HCC. The results also reveal the therapeutic potential for low-dose 5-AzadC to enhance the HMDB-induced death of HCC cells. Mol Cancer Ther; 14(11); 2623–33. ©2015 AACR.
Histórias editadas: um estudo de caso sobre o uso do clipping como material documental
Authors: Machado Bernardo Fonseca 
Published: September 2015

<div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>Este artigo analisa o clipping da Cia. de Teatro Os Satyros presente em sua sede. Seu objetivo é investigar como o grupo criou uma </span><em>história de si </em><span>utilizando-se da seleção e edição do material publicado pela imprensa. Pretende-se contribuir para uma historiografia do teatro brasileiro analisando narrativas que se tornaram “oficiais” e naturalizadas por profissionais de teatro – grupos, diretores(as), atores e atrizes etc. A metodologia está baseada no contraste de fontes e documentos a fim de compreender como narrativas históricas são criadas pelos próprios agentes. </span></p></div></div></div>
Dialética cadavérica em Mãe, de José de Alencar
Authors: Delmanto Ivan 
Published: September 2015

<div class="page" title="Page 2"><div class="layoutArea"><div class="column"><p><span>O presente artigo realiza uma análise do texto </span><em>Mãe</em><span>, de José de Alencar, investigando as relações de tensão entre a forma teatral e o tecido histórico brasileiro, procurando estabelecer uma releitura da experiência estética e questionando a possibilidade de apreensão, nas cicatrizes, limitações e contradições do texto teatral, de índices da realidade histórica. </span></p></div></div></div>
The efficacy of intrauterine injection of human chorionic gonadotropin before embryo transfer in assisted reproductive cycles: Meta-analysis
Authors: Ye Hong , Hu Jing , He Wencong , Zhang Yong , Li Caihong 
Published: September 2015

Objectives A systematic review and meta-analysis to evaluate the effect of human chorionic gonadotropin (hCG) intrauterine injection before embryo transfer on the outcome of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods Searches of PubMed®, EMBASE®, EBSCO, Web of Science®, SCOPUS® and Cochrane Central Register of Controlled Trials were conducted to retrieve relevant randomized controlled trials (RCTs). Data were extracted and analysed. Results The meta-analysis included five RCTs (hCG group n = 680; control group n = 707). Intrauterine hCG injection significantly increased rates of biochemical, clinical and ongoing pregnancy compared with controls. There were no between-group differences in implantation or miscarriage rates. Conclusion Women undergoing IVF/ICSI may benefit from intrauterine hCG injection before embryo transfer.
Prevalence and correlates of suicidal thoughts in patients with neuropsychiatric lupus
Authors: Hajduk A , Nowicka-Sauer K , Smoleńska Ż , Czuszyńska Z , Zdrojewski Z 
Published: September 2015

Background Suicidal ideation is observed in patients with systemic lupus erythematosus (SLE). No study on this notable phenomenon in neuropsychiatric SLE (NPSLE) is available so far. Methods Participants were 53 consecutive outpatients with NPSLE (48 women; mean age 43.8 years) diagnosed according to the American College of Rheumatology nomenclature for SLE neuropsychiatric syndromes. A Neuropsychiatric Questionnaire (NP-Q) concerning 45 neurological, cognitive and psychiatric symptoms was used to assess the prevalence of self-perceived neuropsychiatric symptoms. The Modified Hospital Anxiety and Depression Scale (HADS-M) was used to assess the level of anxiety, depression and irritability. Formal neuropsychological examination was performed. Clinical data were collected by means of medical charts review and structured interview. Results Suicidal thoughts were present in 25% of patients with NPSLE, irrespective of sex, age, education, work status, disease duration and steroid treatment. Suicidal ideation was connected with elevated levels of depression, anxiety and irritability. In patients with suicidal ideation the prevalence of cognitive, psychiatric and neurological self-perceived problems was significantly higher. Conclusions Suicidal thoughts are common in patients with NPSLE. Neuropsychiatric manifestation per se, depression, anxiety and patients’ subjective complaints can be risk factors for suicidal ideation. Screening for suicidal thoughts is vital in routine care of SLE patients.
Metabolic syndrome is associated with decreased circulating endothelial progenitor cells and increased arterial stiffness in systemic lupus erythematosus
Authors: Castejon R , Jimenez-Ortiz C , Rosado S , Tutor-Ureta P , Mellor-Pita S , Yebra-Bango M 
Published: September 2015

Objectives Metabolic syndrome (MetS) is highly prevalent in patients with systemic lupus erythematosus (SLE) and it has been associated with increased cardiovascular risk. We examined the contribution of MetS to inflammatory markers, arterial stiffness and circulating endothelial progenitor cells (EPCs) as surrogates of subclinical atherosclerosis. Methods Cardiovascular risk factors, SLE-specific factors and peripheral blood EPCs were assessed in 50 female SLE patients. MetS was defined according to the National Cholesterol Education Program Adult Treatment Panel III. Simultaneously, atherosclerosis was assessed by measuring the carotid–femoral pulse wave velocity (PWV) by doppler velocimetry. Results Beyond the factors included in the definition, SLE patients with MetS have a significantly higher serum level of uric acid (6.88 ± 2.20 vs 4.45 ± 1.17, p < 0.001) and some inflammatory biomarkers such as homocysteine, IL-8, sICAM-1 or complement molecules. The presence of MetS in our patients was closely linked with a significantly increased patient organ damage score (3.20 ± 1.97 vs 1.60 ± 1.67, p = 0.008), a decreased percentage of circulating EPCs (0.53 ± 0.24 vs 0.85 ± 0.57, p = 0.007) and an increased arterial stiffness (9.89 ± 2.40 vs 7.13 ± 1.51, p < 0.001). Conclusions MetS may contribute to the development of atherosclerosis by significantly increasing inflammation levels and arterial stiffness and decreasing circulating EPCs. This finding would justify close monitoring of these patients.
Vitamin D as a risk factor for premature atherosclerosis in patients with type 2 diabetes
Authors: Hamdy Al-Said Nehal , Abd El Ghaffar Mohamed Nagwa , Salam Randa F. , Fawzy Mary Wadie 
Published: September 2015

Background: Several cardiovascular risk factors have been recognized in patients with diabetes and vitamin D deficiency is emerging as a new risk. The aim of this study was to determine the effect of vitamin D deficiency on the incidence of premature atherosclerosis in patients with type 2 diabetes. Methods: A total of 78 patients with type 2 diabetes were subjected to history taking, physical examination, fasting glucose level, homeostasis model assessment of insulin resistance, lipid profile, 25(OH) vitamin D measurement, and carotid Doppler. Results: Patients with normal carotid intima-media thickness (CIMT) had sufficient vitamin D. Of those with increased CIMT 23.1% had insufficient vitamin D while 76.9% had sufficient vitamin D (six patients had plaques, one of them had vitamin D insufficiency, and the other five patients had sufficient vitamin D). There was a statistically significant difference in the serum level of vitamin D between patients with increased CIMT, and those with normal intima, with a decreased level in the first group. There was a significant negative correlation between vitamin D and fasting blood glucose. There was a statistically significant correlation in left CIMT between the vitamin D sufficiency group and the vitamin D insufficiency group, with higher values in the second group. There was no statistically significant difference in serum cholesterol, triglycerides, HDL cholesterol, and LDL cholesterol in patients with increased CIMT and those with normal intima. Conclusions: Decreased vitamin D levels in patients with diabetes lead to increased CIMT. The absence of a statistically significance difference in lipid profile between increased and normal CIMT groups raises the possibility of underlying causes for atherosclerosis in patients with diabetes other than dyslipidemia.
Teaching How to Write Better Essays at the Middle School
Authors: Воителева  , Voiteleva T. , Обернихина  , Obyernikhina Galina , Марченко  , Marchenko O. 
Published: September 2015

The paper considers methods of teaching school students how to write essays, given that it is the basic form of writing activities in the process of teaching
the Russian language and literature at the middle school. Emphasized are the different kinds of essays in terms of types of speech, such as narration,
description, discourse.
Contract Preferences and Performance for the Loss-Averse Supplier: Buyback vs. Revenue Sharing
Authors: Zhang Yinghao , Donohue Karen , Cui Tony Haitao 
Published: September 2015

Prior theory claims that buyback and revenue-sharing contracts achieve equivalent channel-coordinating solutions when applied in a dyadic supplier–retailer setting. This suggests that a supplier should be indifferent between the two contracts. However, the sequence and magnitude of costs and revenues (i.e., losses and gains) vary significantly between the contracts, suggesting the supplier’s preference of contract type, and associated contract parameter values, may vary with the level of loss aversion. We investigate this phenomenon through two studies. The first is a preliminary study investigating whether human suppliers are indeed indifferent between these two contracts. Using a controlled laboratory experiment, with human subjects taking on the role of the supplier having to choose between contracts, we find that contract preferences change with the ratio of overage and underage costs for the channel (i.e., the newsvendor critical ratio). In particular, a buyback contract is preferred for products with low critical ratio, whereas revenue sharing is preferred for products with high critical ratio. We show these results are consistent with the behavioral tendency of loss aversion and are more significant for subjects who exhibit higher loss aversion tendencies in an out of context task. In the second (main) study, we examine differences in the performance of buyback and revenue-sharing contracts when suppliers have the authority to set contract parameters. We find that the contract frame influences the way parameters are set and the critical ratio again plays an important role. More specifically, revenue-sharing contracts are more profitable for the supplier than buyback contracts in a high critical ratio environment when accounting for the supplier’s parameter-specification behavior. Also, there is little difference in performance between the two contracts in a low critical ratio environment. These results can help inform supply managers on what types of contracts to use in different critical ratio settings. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2015.2182 . This paper was accepted by Martin Lariviere, operations management.
Intraspecific Molecular Variation of Allium ursinum (Amaryllidaceae) Across the Border of Two Subspecies Distribution Ranges
Authors: Rola Kaja , Lenart-Boroń Anna , Boroń Piotr , Osyczka Piotr 
Published: September 2015

AbstractThe study investigates the genetic differentiation among two subspecies ofAllium ursinumL., namelyA. ursinumsubsp.ursinumand subsp.ucrainicumas well as their putative hybrid that is represented by individuals with intermediate morphology. Inter-Simple Sequence Repeats (ISSR) were applied to determine the status of intermediate morphotypes in terms of their genetic pattern and to assess the level of genetic variability within and between various populations ofA. ursinum. The study comprises 144 specimens from nine populations along the east-west transect in Poland, which includes localities of both subspecies and their putative hybrid. Among the examined populations, 48 bands were amplified, of which 45 were found to be polymorphic. The principal coordinate analysis (PCoA), the neighbour-net analysis and Mantel test showed a strong correlation between genetic variability and geographic distance. Analysis of molecular variance (AMOVA) revealed that a greater proportion of total genetic variation resided within populations rather than among them. The Structure Bayesian clustering analysis revealed the presence of three distinct genetic groups within studied populations, where ‘eastern’ genotypes correspond toA. ursinumsubsp.ucrainicum, and ‘western’ to subsp.ursinum; whereas the third genetic group has the largest share in the individuals occurring at the border of the distribution ranges of both subspecies. The emergence of the third genetic group is probably an effect of hybridization events occurring within the secondary contact zone. Typical morphologically intermediate populations occur only in a relatively narrow geographical zone, but the hybrid zone revealed by molecular markers is actually much wider than it is suggested by the morphological pattern of individuals. The current distribution pattern of both subspecies ofA. ursinumand their hybrid zone is related to the two main directions of postglacial migration ofFagus sylvaticato the area of Poland. The hybrid zone arose as an effect of the secondary contact of two divergent lineages ofA. ursinum.
Arabidopsis thaliana Tolerates Iron Deficiency more than Thellungiella Salsuginea by Inducing Metabolic Changes at the Root Level
Authors: Msilini Najoua , Ferhi Jihed , Chebbi Mohamed , Lachaâl Mokhtar , Ouerghi Zeineb 
Published: September 2015

Abstract
Several studies have used A. thaliana as a model to identify the physiological and molecular mechanisms underlying iron deficiency tolerance in plants. Here, Arabidopsis thaliana and Thellungiella salsuginea were used to investigate the differential responses to iron deficiency of these two species. Plants were cultivated in hydroponic medium containing 5 or 0 μM Fe, for 10 days. Results showed that rosette biomass was more reduced in T. salsuginea than in A. thaliana when grown on Fe-deficient medium. As a marker for iron deficiency tolerance, the induction of ferric chelate reductase (FCR) and phosphoenolpyruvate carboxylase (PEPC) activities was observed only in A. thaliana roots. In addition, we found that the accumulation of phenolic acids in roots of N1438 ecotype of A. thaliana was stimulated by Fe deficiency. Furthermore, an increase of flavonoids content in the root and exudates was observed under Fe-deficiency in this ecotype. Unlike other abiotic stresses, it appears that iron deficiency effects were more pronounced in Thellungiella than in Arabidopsis. The higher tolerance of the Arabidopsis plant to iron deficiency may be due to the metabolic changes occurring in the roots.
Zur historischen Einordnung von Jakob Brückers Interpunktionslehre
Authors: Rinas Karsten 
Published: September 2015

AbstractThis article offers an analysis of the punctuation theory of Jakob Brücker, published in his ›Teutsche Grammatic‹ (1620). It is shown that this is the first German theory which adds semantic and syntactic conditions to the theory of the period developed within the framework of classical rhetoric. It is likely that Brücker’s approach is, directly or indirectly, indebted to the theory of Aldus Manutius, the Younger (1566). Furthermore, this article deals with the question to what extent Brücker’s theory influenced later approaches (by Gueintz, Harsdörffer, Schottel, Bödiker).
The effects of educating mothers and girls on the girls’ attitudes toward puberty health: a randomized controlled trial
Authors: Afsari Atousa , Mirghafourvand Mojgan , Valizadeh Sousan , Abbasnezhadeh Massomeh , Galeshi Mina , Fatahi Samira 
Published: September 2015

Abstract

Introduction:
The attitude of a girl toward her menstruation and puberty has a considerable impact on her role during motherhood, social adjustment, and future marital life. This study was conducted in 2014 with the aim of comparing the effects of educating mothers and girls on the attitudes of adolescent girls of Tabriz City, Iran, towards puberty health.

Methods:
This randomized control clinical trial was conducted on 364 adolescent girls who experienced menstruation. Twelve schools were selected randomly among 107 secondary schools for girls. One-third of the students of each school were selected randomly using a table of random numbers and socio-demographic and each participant was asked to answer the attitude questionnaires. The schools were randomly allocated to the groups of mother’s education, girl’s education, and no-intervention. The attitude questionnaire was filled out by the participants again 2 months after intervention. The general linear model, in which the baseline values were controlled, was employed to compare the scores of the three groups after the intervention.

Results:
No significant differences were observed among the three groups in terms of the attitude score before intervention (p>0.05). Attitude score improvement after intervention in the girl’s education group was significantly higher than the one of both mother’s education (adjusted mean difference [AMD]: 1.8; [95% confidence interval (CI): 0.4–1.3]) and no-intervention groups (AMD: 1.3; [95% CI: 0.0–2.6]) by controlling the attitude score before intervention.

Conclusion:
Based on the findings, it is more effective to educate girls directly about puberty health to improve adolescent girls’ attitudes than educating mothers and asking them to transfer information to the girls. Nevertheless, studies with longer training period and follow-up are proposed to determine the effects of educating girls (through their mothers) on their attitudes about puberty health.
Remote Monitoring for Solar Photovoltaic Systems in Rural Application Using GSM Network
Authors: Ahmad Tanveer , Hasan Qadeer Ul , Malik A. , Awan N. S. 
Published: September 2015

Abstract
This paper presents design and development of solar power monitoring and control through GSM network in rural application. This system includes a GSM mobile and GSM hardware installed at solar system with 12VDC power for solar power monitoring along with temperatures (ambient and battery). This system is designed to conceptualizing how much solar power transferred to batteries and temperature conditions for that instant of time. Hardware is developed for the continuous update to the targeted station using GSM. The developed hardware gets the signal from the installed location calculate the real time power and temperature parameters. This information transferred to targeted mobile station through GSM interface using texting service (SMS). At the receiving end, power monitoring system is used to maintain the power to batteries profile locally. An easy, cost proficient and consistent working model of whole system has been developed which may be incorporated for data acquisition. Also the same system can use for uninterrupted power supply (UPS) systems.
A brief illustrated history on sunscreens and sun protection
Authors: Svarc Federico 
Published: September 2015

AbstractNobody exactly knows when human beings begun protecting their skin from the sun. Our dark-skinned ancestors in Africa had the benefit of natural melanin to avoid sunburn. With migration to cooler regions, humans clothed themselves to avoid frost, losing their protective pigmentation. For cultural reasons, occidentals continued to cover their body up to the XIXthcentury. After World War I fashion wanted tanned bodies. Oils without protection to UV radiation were used. In 1935 Eugène Schueller, founder of L’Oreal, formulated the first radiation filtering product,“Ambre Solaire Huile”. Benjamin Green produced for the soldiers battling in the Pacific a red jelly substance as a physical blocker. The hazards of sun overexposure were already apparent. The product boomed under the brand Coppertone. In 1946 Franz Greiter developed the“Gletscher Créme”. In 1956 R. Schulz introduced the concept of the sun protection factor (SPF). All those products protected only against UVB radiation, whose main visible result is erythema. There was still no concern on the more penetrating UVA radiation, and skin cancer prevention nor on several other contemporary issues. Today we benefit from very high SPF products with broad UV protection. Solubility limitations and sensorial properties make them difficult to formulate and stabilize.