bluuebunny/crossref_metadata_2025_split huggingface dataset:
Time course of arthralgia among women initiating aromatase inhibitor therapy and a postmenopausal comparison group in a prospective cohort
Authors: Castel Liana D. , Hartmann Katherine E. , Mayer Ingrid A. , Saville Benjamin R. , Alvarez JoAnn , Boomershine Chad S. , Abramson Vandana G. , Chakravarthy A. Bapsi , Friedman Debra L. , Cella David F. 
Published: April 2013

BACKGROUNDMore than 80,000 postmenopausal breast cancer patients in the United States each year are estimated to begin a 5‐year course of aromatase inhibitors (AIs) to prevent recurrence. AI‐related arthralgia (joint pain and/or stiffness) may contribute to nonadherence, but longitudinal data are needed on arthralgia risk factors, trajectories, and background in postmenopause. This study sought to describe 1‐year arthralgia trajectories and baseline covariates among patients with AI and a postmenopausal comparison group.METHODSPatients initiating AIs (n = 91) were surveyed at the time of AI initiation and at 6 repeated assessments over 1 year. A comparison group of postmenopausal women without breast cancer (n = 177) completed concomitantly timed surveys. Numeric rating scales (0–10) were used to measure pain in 8 joint pair groups (bilateral fingers, wrists, elbows, shoulders, hips, knees, ankles, and toes). Poisson regression models were used to analyze arthralgia trajectories and risk factors.RESULTSBy week 6, the AI‐initiating group had more severe arthralgia than did the comparison group (ratio of means = 1.8, 95% confidence interval = 1.24‐2.7, P = .002), adjusting for baseline characteristics. Arthralgia then worsened further over 1 year in the AI group. Menopausal symptom severity and existing joint‐related comorbidity at baseline among women initiating AI were associated with more severe arthralgia over time.CONCLUSIONSPatients initiating AI should be told about the timing of arthralgia over the first year of therapy, and advised that it does not appear to resolve over the course of a year. Menopausal symptoms and joint‐related comorbidity at AI initiation can help identify patients at risk for developing AI‐related arthralgia. Cancer 2013;119:2375–2382. © 2013 American Cancer Society.
Optimization of the systemic inflammation‐based Glasgow Prognostic Score
Authors: Proctor Michael J. , Horgan Paul G. , Talwar Dinesh , Fletcher Colin D. , Morrison David S. , McMillan Donald C. 
Published: April 2013

BACKGROUNDThe modified Glasgow Prognostic Score (mGPS), an inflammation‐based prognostic score that uses thresholds of C‐reactive protein (> 10 mg/L) and albumin (< 35 g/L), has been found to be independently prognostic of survival in patients with cancer. The objective of the current study was to establish whether the addition of a differential leukocyte count and a high‐sensitivity C‐reactive protein measurement enhanced the prognostic value of the mGPS.METHODSA total of 12,119 patients who had an incidental blood sample taken between 2000 and 2007 for C‐reactive protein, albumin, and a differential leukocyte count as well as a diagnosis of cancer made within 2 years were identified. This group was studied for the prognostic value of neutrophil, lymphocyte, and platelet counts. In addition 2742 patients whose blood was sampled after the introduction of high‐sensitivity C‐reactive protein measurements were studied for the prognostic value of different thresholds.RESULTSUsing cancer‐specific survival as an endpoint, the prognostic value of the mGPS (hazard ratio [HR], 2.61; P < .001 [area under the receiver operating characteristic curve (AUC), 0.695]) was found to be improved by the addition of neutrophil and platelet counts (HR, 4.86; P < .001 [AUC, 0.734]) and a high‐sensitivity C‐reactive protein measurement (> 3 mg/L) (HR, 5.77; P < .001 [AUC, 0.734]).CONCLUSIONSThe results of the current study demonstrate that the addition of neutrophil and platelet counts, as well as a high‐sensitivity C‐reactive protein measurement, enhanced the prognostic value of the mGPS. Cancer 2013;119:2325–2332. © 2013 American Cancer Society.
Progress report of a randomized trial comparing long‐term survival and late toxicity of concurrent chemoradiotherapy with adjuvant chemotherapy versus radiotherapy alone in patients with stage III to IVB nasopharyngeal carcinoma from endemic regions of China
Authors: Chen Yong , Sun Ying , Liang Shao‐Bo , Zong Jing‐Feng , Li Wen‐Fei , Chen Mo , Chen Lei , Mao Yan‐Ping , Tang Ling‐Long , Guo Ying , Lin Ai‐Hua , Liu Meng‐Zhong , Ma Jun 
Published: April 2013

BACKGROUNDThe objective of this study was to evaluate the long‐term survival and late toxicities of concurrent‐adjuvant chemotherapy in patients with stage III through IVB nasopharyngeal carcinoma (NPC) from endemic regions of China.METHODSPatients with stage III to IVB NPC were assigned randomly to receive radiotherapy (RT) alone (the RT group) or RT plus concurrent adjuvant chemotherapy (the CRT group). CRT patients received concurrent cisplatin (40 mg/m2) weekly during RT followed by cisplatin (80 mg/m2) and fluorouracil (800 mg/m2 daily for 5 days) every 4 weeks for 3 cycles. The primary endpoint was overall survival.RESULTSIn total, 316 patients underwent randomization, with 158 to each group. At a median follow‐up of 70 months, the 5‐year overall survival rate was 72% for the CRT group and 62% for the RT group (hazard ratio, 0.69; 95% confidence interval, 0.48‐0.99; P = .043). Failure‐free survival was significantly higher in the CRT group (P = .020). Most late toxicities were similar (33% vs 26%; P = .089), except for cranial neuropathy (P = .042), peripheral neuropathy (P = .041), and ear damage (P = .048), which were significantly increased in the CRT group.CONCLUSIONSThe addition of concurrent adjuvant chemotherapy to RT provides survival benefits to patients with stage III through IVB NPC in endemic regions of China, and it does not increase most late toxicities apart from cranial neuropathy, peripheral neuropathy, and ear damage. Cancer 2013;119:2230–2238. © 2013 American Cancer Society.
Expression of ZNF148 in different developing stages of colorectal cancer and its prognostic value
Authors: Gao Xian‐Hua , Liu Qi‐Zhi , Chang Wenjun , Xu Xiao‐Dong , Du Yan , Han Yifang , Liu Yan , Yu Zhi‐Qi , Zuo Zhi‐Gui , Xing Jun‐Jie , Cao Guangwen , Fu Chuan‐Gang 
Published: April 2013

BACKGROUNDIt has been speculated that zinc finger protein 148 (ZNF148) is a tumor suppressor. However, to the authors' knowledge, little is known about the clinical significance of ZNF148 expression in patients with colorectal cancer (CRC). The objective of the current study was to clarify the association between ZNF148 expression and the postoperative prognosis of patients with CRC.METHODSTissue microarrays containing 56 normal mucosa, 51 adenoma, 742 CRC (TNM stage I‐IV), 16 familial adenomatous polyposis, and 21 metastatic CRC specimens were examined immunohistochemically for ZNF148 expression.RESULTSExpression of ZNF148 was found to increase consecutively from normal mucosa to stage I CRC, and then decreased consecutively from stage I to stage IV CRC. Lower expression of ZNF148 in tumors was found to be significantly associated with lymph node metastases, advanced TNM disease stage, poor differentiation, higher rate of disease recurrence, worse overall survival (OS), and shorter disease‐free survival. High expression of ZNF148 was also associated with improved OS (P = .025) and disease‐free survival (P = .042) in patients with stages II to III CRC. On multivariate Cox analysis, lower ZNF148 expression in tumors, advanced TNM stage, colon cancer, and elevated serum carbohydrate antigen 19‐9 (CA19‐9) were found to be significant factors for a worse OS. In 16 patients with familial adenomatous polyposis, ZNF148 expression was upregulated at steps toward carcinogenesis. In 21 patients with metastatic CRC, although ZNF148 expression was higher in primary tumors compared with adjacent mucosa, its expression in metastatic tumors was significantly lower than that in primary tumors.CONCLUSIONSAlthough ZNF148 expression is related to colorectal carcinogenesis, high ZNF148 expression in patients with CRC appears to be inversely associated with malignant phenotypes and may serve as a significant prognostic factor after surgery for patients with CRC. Cancer 2013;119:2212–2222. © 2013 American Cancer Society.
Strong Light‐Molecule Coupling on Plasmonic Arrays of Different Symmetry
Authors: Salomon Adi , Wang Shaojun , Hutchison James A. , Genet Cyriaque , Ebbesen Thomas W. 
Published: April 2013

AbstractThe strong coupling of porphyrin J‐aggregates to plasmonic nanostructures of different symmetry is investigated. The nanostructures of higher symmetry show the strongest interaction with the molecular layer, suggesting that surface plasmon mode degeneracy plays an important role in the coupling efficiency. At high coupling strengths a new, weakly dispersive mode appears which has recently been predicted theoretically to be due to long‐range energy transfer between molecules mediated by surface plasmons. These findings point to new ways for optimizing strong coupling and thereby realize its full potential for molecular and material science.
Theoretical Investigation of Generator–Collector Microwell Arrays for Improving Electroanalytical Selectivity: Application to Selective Dopamine Detection in the Presence of Ascorbic Acid
Authors: Oleinick Alexander , Zhu Feng , Yan Jiawei , Mao Bingwei , Svir Irina , Amatore Christian 
Published: April 2013

AbstractRecessed generator–collector assemblies consisting of an array of recessed disks (generator electrodes) with a gold layer (collector electrode) deposited over the top‐plane insulator reportedly allow increased selectivity and sensitivity during electrochemical detection of dopamine (DA) in the presence of ascorbic acid (AA), a situation which is frequently encountered. In sensor design, the potential of the disk electrodes is set to the wave plateau of DA, whereas the plane electrode is biased at the irreversible wave plateau of AA before the onset of the DA oxidation wave. Thus, AA is scavenged but DA is allowed to enter the nanocavities to be oxidized at the disk electrodes, and its signal is further amplified by redox cycling between disk and plane electrodes. Several different theoretical approaches are elaborated herein to analyze the behavior of the system, and their conclusions are successfully tested by experiments. This reveals the crucial role of the plane‐electrode area which screens access to the recessed disks (i.e. acts as a diffusional Faraday cage) and simultaneously contributes to amplification of the analyte signal through positive feedback, as occurs in interdigitated arrays and scanning electrochemical microscopy. Simulations also allow for the evaluation of the benefits of different geometries inspired by the above design and different operating modes for increasing the sensor performance.
Lipase‐Mediated Selective Oxidation of Furfural and 5‐Hydroxymethylfurfural
Authors: Krystof Monika , Pérez‐Sánchez María , Domínguez de María Pablo 
Published: April 2013

AbstractFurfural and 5‐hydroxymethylfurfural (HMF) are important biomass‐derived platform chemicals that can be obtained from the dehydration of lignocellulosic sugars. A possible route for the derivatization of furanics is their oxidation to afford a broad range of chemicals with promising applications (e.g., diacids, hydroxyl acids, aldehyde acids, monomers for novel polymers). Herein we explore the organic peracid‐assisted oxidation of furanics under mild reaction conditions. Using lipases as biocatalysts, alkyl esters as acyl donors, and aqueous solutions of hydrogen peroxide (30 % v/v) added stepwise, peracids are formed in situ, which subsequently oxidize the aldehyde groups to afford carboxylic acids with high yields and excellent selectivities. Furthermore, the use of an immobilized silica‐based 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO) affords the selective oxidation of the hydroxymethyl group of HMF to afford 2,5‐diformylfuran. That product can be subsequently oxidized using again lipases for the in situ peracid formation to yield 2,5‐furandicarboxylic acid, which is considered to be a key building block for biorefineries. These lipase‐mediated reactions proceeded efficiently even with high substrate loadings under still non‐optimized conditions. Overall, a proof‐of‐concept for the oxidation of furanics (based on in situ formed organic peracids as oxidants) is provided.
Radio‐frequency energy harvesting potential: a stochastic analysis
Authors: Guo Weisi , Wang Siyi 
Published: April 2013

ABSTRACTThis paper considers the energy harvesting potential from ambient electromagnetic waves in the radio frequency (RF) communications spectrum. Because of chaotic positioning nature of cells, handsets and hotspots, the analysis employs stochastic geometry theory to derive the mean and probability distribution of the received RF radiation energy available for harvesting. The mean and density function of energy harvested, as a function of transmitter deployment density, spectrum and pathloss characteristics are given. The novel benefit is that the derived expressions serve as a design guideline for RF harvesting solutions. For a given power harvesting and reliability requirement, the expressions in this paper can yield insight into which set and how many RF spectrum bands to harvest. Copyright © 2013 John Wiley & Sons, Ltd.
Combined analysis of Xylopia rubescens Oliv. leaf oil using gas chromatography with flame ionization detection, gas chromatography with mass spectrometry and 13C nuclear magnetic resonance: structure elucidation of new compounds
Authors: Yapi Thierry Acafou , Boti Jean Brice , Ahibo Antoine Coffy , Bighelli Ange , Casanova Joseph , Tomi Félix 
Published: April 2013

ABSTRACTPhytochemicals have been isolated from extracts of various Xylopia species (Annonaceae) growing wild in the African rainforest. In contrast, no phytochemical investigations have been reported to date on Xylopia rubescens Oliv. The aim of the present work was to describe the composition of X. rubescens leaf oil. Analysis of the leaf oil has been undertaken by a combination of chromatographic and spectroscopic techniques. Three new compounds have been isolated and their structures elucidated as furanoguaia‐1,4‐diene, furanoguaia‐1,3‐diene and (8Z,11Z,14Z)‐8,11,14‐heptadecatrien‐2‐ol. One other compound is reported for the first time as a natural compound. The oil composition was dominated by both furanoguaiadienes (34.2% and 11.4%, respectively) and by (8Z,11Z,14Z)‐8,11,14‐heptadecatrien‐2‐one (12.8%). The composition of X. rubescens leaf oil varied dramatically from those of the essential oils isolated from other Xylopia species. Copyright © 2013 John Wiley & Sons, Ltd.
α‐Aminophosphonates and α‐Aminophosphine Oxides by the Microwave‐Assisted Kabachnik–Fields Reactions of 3‐Amino‐6‐methyl‐2 H‐pyran‐2‐ones
Authors: Bálint Erika , Takács Judit , Drahos László , Juranovič Amadej , Kočevar Marijan , Keglevich György 
Published: April 2013

ABSTRACTThe microwave‐assisted Kabachnik–Fields reaction of a series of 3‐amino‐6‐methyl‐2H‐pyran‐2‐ones, paraformaldehyde, and dialkyl phosphites or diphenylphosphine oxide led to α‐aminophosphonates or α‐aminophosphine oxides, respectively. The α‑aminophosphonates were obtained under solvent‐free conditions, whereas the α‑aminophosphine oxides in acetonitrile. The novel products were characterized by NMR and mass spectral data. © 2013 Wiley Periodicals, Inc. Heteroatom Chem 24:221–225, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21086
PDE10 inhibition increases GluA1 and CREB phosphorylation and improves spatial and recognition memories in a Huntington's disease mouse model
Authors: Giralt Albert , Saavedra Ana , Carretón Olga , Arumí Helena , Tyebji Shiraz , Alberch Jordi , Pérez‐Navarro Esther 
Published: April 2013

ABSTRACTHuntington's disease (HD) causes motor disturbances, preceded by cognitive impairment, in patients and mouse models. We showed that increased hippocampal cAMP‐dependent protein kinase (PKA) signaling disrupts recognition and spatial memories in R6 HD mouse models. However, unchanged levels of hippocampal phosphorylated (p) cAMP‐responsive element‐binding protein (CREB) suggested unaltered nuclear PKA activity in R6 mice. Here, we extend this finding by showing that nuclear pPKA catalytic subunit (Thr197) and pPKA substrate levels were unaltered in the hippocampus of R6/1 mice. Phosphodiesterases (PDEs) play an important role in the regulation of PKA activity. PDE10A, a cAMP/cGMP dual‐substrate PDE, was reported to be restricted to the nuclear region in nonstriatal neurons. Using cell fractionation we confirmed that PDE10A was enriched in nuclear fractions, both in wild‐type and R6/1 mice hippocampus, without differences in its levels or intracellular distribution between genotypes. We next investigated whether inhibition of PDE10 with papaverine could improve cognitive function in HD mice. Papaverine treatment improved spatial and object recognition memories in R6/1 mice, and significantly increased pGluA1 and pCREB levels in R6/1 mice hippocampus. Papaverine likely acted through the activation of the PKA pathway as the phosphorylation level of distinct cGMP‐dependent kinase (cGK) substrates was not modified in either genotype. Moreover, hippocampal cAMP, but not cGMP, levels were increased after acute papaverine injection. Our results show that inhibition of PDE10 improves cognition in R6 mice, at least in part through increased GluA1 and CREB phosphorylation. Thus, PDE10 might be a good therapeutic target to improve cognitive impairment in HD. © 2013 Wiley Periodicals, Inc.
Doped Nano‐Sized Copper(I) Oxide (Cu2O) on MelamineFormaldehyde Resin: a Highly Efficient Heterogeneous Nano Catalyst for ‘Click’ Synthesis of Some Novel 1H‐1,2,3‐Triazole Derivatives Having Antibacterial Activity
Authors: Rad Mohammad Navid Soltani , Behrouz Somayeh , Movahedian Abdollah , Doroodmand Mohammad Mahdi , Ghasemi Younes , Rasoul‐Amini Sara , Gandomani Abdol‐Rasoul Ahmadi , Rezaie Ramin 
Published: April 2013

AbstractA facile and simple protocol for the 1,3‐dipolar cycloaddition of organic azides with terminal alkynes catalyzed by doped nano‐sized Cu2O on melamineformaldehyde resin (nano‐Cu2OMFR) as a new and convenient heterogeneous catalyst is described. In this method, ‘click’ cycloaddition of various structurally diverse β‐azido alcohols and alkynes in the presence of nano‐Cu2OMFR in H2O/THF 1 : 2 furnished the corresponding 1,4‐disubstituted 1H‐1,2,3‐triazole adducts 1a–1o in good to excellent yields at room temperature (Scheme and Table 3). The nano‐Cu2OMFR was characterized by scanning electron microscopy (SEM), X‐ray diffraction (XRD), inductively coupled plasma (ICP) analysis, and FT‐IR. The nano‐Cu2OMFR could be easily recovered and recycled from the reaction mixture and reused for many consecutive trials without significant decrease in activity (Table 4). The in vitro antibacterial activities of all synthesized compounds were tested on several Gram‐positive and/or Gram‐negative bacteria (Table 5). The results demonstrate the promising antibacterial activity for some of the synthesized compounds.
Cytotoxic Diterpenoids from the Stem Bark of Annona squamosa L.
Authors: Zhou Chang‐Xin , Sun Li‐Rui , Feng Feng , Mo Jian‐Xia , Zhu Hong , Yang Bo , He Qiao‐Jun , Gan Li‐She 
Published: April 2013

AbstractThree new ent‐kaurane diterpenoids, (4α)‐19‐nor‐ent‐kaurane‐4,16,17‐triol (1), (4α,16α)‐17‐(acetyloxy)‐19‐nor‐ent‐kaurane‐4,16‐diol (2), and 17‐hydroxy‐ent‐kaur‐15‐en‐19‐al (3), together with 11 known compounds, were isolated from the stem bark of Annona squamosa L. The structures of 1–3 were identified by analysis of their spectroscopic data. All compounds were evaluated for cytotoxic activity against human lung cancer (95‐D) and ovarian cancer (A2780) cell lines, and compounds 3, 5, 7, 11–14 exhibited promising antiproliferative activities with IC50 values ranging from 0.38 to 34.66 μM.
Bis‐Diterpenoid Alkaloids from Aconitum tanguticum var. trichocarpum
Authors: Zhang Zhong‐Tang , Chen Dong‐Lin , Chen Qiao‐Hong , Wang Feng‐Peng 
Published: April 2013

AbstractPhytochemical investigation of the whole herbs of Aconitum tanguticum (Maxim.) Stapf var. trichocarpum Hand.‐Mazz. led to the isolation of one heteratisine‐hetidine‐type bis‐diterpenoid alkaloid, trichocarpidine (1), three hetidine‐hetisine type bis‐diterpenoid alkaloids, trichocarpinine A–C (2–4, resp.), together with nine known compounds. Their structures were elucidated by spectroscopic analyses.
New Synthetic Approaches to Naturally Occurring and Unnatural Pyranoflavones
Authors: Xia Likai , Rok Lee Yong 
Published: April 2013

AbstractTotal synthesis of biologically interesting natural and unnatural pyranoflavones has been accomplished starting from readily available 2,4‐dihydroxyacetophenone or 2,4‐dihydroxy‐6‐methoxyacetophenone in three steps, i.e., benzopyran formation, condensation, and cyclization reaction.
Organic Stereochemistry. Part 4
Authors: Testa Bernard , Vistoli Giulio , Pedretti Alessandro 
Published: April 2013

AbstractThis Part 4 continues a general presentation of the principles of stereochemistry with special reference to medicinal compounds and their interactions with biological systems. Here, we discuss and illustrate two major aspects of conformational isomerism, namely a) the concept of torsional isomerism about single bonds, and b) the intertwined conformational and configurational aspects of the stereochemistry of cyclic systems. The review begins with a brief reminder of the history and thermodynamics of conformational isomerism, and goes on to explain and illustrate the conventions and graphical representations used for conformers. Examples are then examined, beginning with ethane, the simplest one, and building up to more complex cases, documenting the attractive or repulsive role of substituents. A similar approach is applied when dealing with cyclic systems, although here the presentation necessarily takes into account configurational aspects specific to cyclic systems. The pharmacological implications of the concepts discussed here will be presented in Part 6.
Experimental study on the effect of porous medium on performance of a single tube heat exchanger: A CO2 case study
Authors: Tarawneh Mohammad , Alshqirate AbedAlrzaq , Khasawneh Khaleel , Hammad Mahmoud 
Published: April 2013

AbstractAn experimental study on single‐phase laminar forced convection in a single porous tube heat exchanger is presented. Parametric studies are conducted for different inlet pressures, different mass flow rates, and different porosities to evaluate the effects of particle diameter and Reynolds number on the heat transfer and friction factor. The Nusselt number and friction factor are developed for efficient design of a porous heat exchanger based on the present configuration. Heat is transferred to the walls of the heat exchanger by natural convection mode. Gravel sand with different porosities is used as a porous medium during the tests. The flow of carbon dioxide as a working fluid in the porous medium is modeled using the Brinkman–Forchheimer‐extended Darcy model. A dimensionless performance parameter is developed in order to be used in evaluating the porous tube heat exchanger based on both the heat transfer enhancement and the associated pressure drop. The study covers a wide range of inlet pressures (Pi), mass flow rates ( $\dot{m}$), porosity of gravel sand (ε), and particle diameters (dm) which ranged 34.5 ≤ Pi ≤ 43 bars, 8 ∗︁ 10−5 ≤$\dot{m}$ ≤ 16 ∗︁ 10−5 kg/s, 34.9% ≤ ε ≤ 44.5%, 1.25 ≤ dm ≤ 5.15 mm, respectively. This study revealed that a smaller particle diameter can be used to achieve higher heat transfer enhancement, but a larger particle diameter leads to a more efficient performance based on heat transfer enhancement. The average heat transfer coefficient of carbon dioxide decreases when the porosity increases. © 2013 Wiley Periodicals, Inc. Heat Trans Asian Res; Published online in Wiley Online Library (wileyonlinelibrary.com/journal/htj). DOI 10.1002/htj.21059