bluuebunny/crossref_metadata_2025_split huggingface dataset:
Românii şi bulgarii la sfârşit de secol XIX şi început de secol XX. Asasinate politice, incidente frontaliere şi tentativa unui complot anarhist/terorist împotriva regelui Carol I (1900-1901)
Authors: NICULAE Daniel Silviu 
Published: July 2024

La începutul anului 1900 relaţiile româno-bulgare erau foarte tensionate, fiind alimentate atât de incidentele petrecute la frontiera de sud, cât şi de atentatele care au avut loc pe teritoriul României, punând astfel pe agenda politicienilor români problema aromânilor din Peninsula Balcanică şi Macedonia, provincie mult râvnită de bulgari, greci şi sârbi, unde bande de comitagii, antarţi şi cetnici luptau atât între ele pentru eliberarea conaţionalilor de sub stăpânirea otomană, cât şi cu trupele turcești. În acest context, asasinatul a ajuns să fie folosit ca armă împotriva adversarilor, fiind prezent în România, Bulgaria, Serbia sau Grecia.La sfârşit de secol XIX, societatea românească a fost trezită brusc la realitate, confruntându-se cu consecinţele modului barbar în care a acţionat unul dintre aceste comitete secrete revoluţionare bulgare, al cărui subcomitet anarhist înfiinţat la Bucureşti, pe care astăzi l-am denumi celulă teroristă, a primit misiunea de a comite mai multe atentate cu bombe pe teritoriul României, precum şi asasinarea regelui Carol I şi a unor demnitari români, în timp ce, la frontiera de sud, grănicerii români raportau zilnic incidente la graniţa comună, al căror scop era destabilizarea şi menţinerea unei stări tensionate pe linia de demarcaţie convenţională dintre România şi Bulgaria.
Gestión del riesgo cambiario: Estrategias y técnicas de gestión financiera internacional
Authors: Shyamsunder Chitta , Soni Hariprasad 
Published: July 2024

El presente estudio examina las creencias y prácticas en torno a la gestión del riesgo cambiario en una muestra heterogénea de participantes. En el contexto contemporáneo de una economía mundial altamente interconectada, la gestión eficaz del riesgo cambiario ha cobrado la máxima importancia para las empresas a fin de proteger su estabilidad financiera y mejorar su competitividad. Mediante el uso del diseño de investigación descriptivo, el estudio abordó las cuestiones con un conjunto diverso de factores demográficos, como el género, la edad y la formación académica, proporcionando información sobre los diversos puntos de vista presentes en las empresas examinadas. El principal objetivo de la investigación descriptiva es proporcionar una descripción y un estudio exhaustivos de las características vinculadas a un determinado acontecimiento, y lo hace sin modificar ningún factor. El análisis de los datos se llevó a cabo con el programa SPSS para la estadística descriptiva, técnicas de dispersión, ANOVA y análisis de modelos de ecuaciones estructurales con IBM AMOS para comprobar las hipótesis. Los resultados del estudio revelan un panorama polifacético de percepciones. Los encuestados muestran perspectivas predominantemente desfavorables con respecto a las técnicas de gestión del riesgo cambiario aplicadas por sus respectivas organizaciones. Se oponen con vehemencia a la aplicación activa de métodos de cobertura, a la utilización competente de instrumentos financieros y a la evaluación periódica de los planes de cobertura. Sin embargo, mantienen una postura neutral a la hora de evaluar la influencia de estas tácticas en los resultados financieros. En resumen, esta investigación pone de relieve la importancia de los esfuerzos continuos encaminados a mejorar la gestión del riesgo cambiario en las empresas. Las organizaciones pueden atravesar con eficacia el intrincado panorama financiero mundial y limitar la influencia de los cambios de divisas en sus resultados financieros abordando de forma proactiva las dificultades reconocidas y fomentando una cultura de mejora continua.
ĐẶC ĐIỂM TẬP TRUNG 18FDG CỦA TỔN THƯƠNG U, HẠCH TRÊN PET/CT Ở BỆNH NHÂN UNG THƯ PHỔI KHÔNG TẾ BÀO NHỎ CÓ CHỈ ĐỊNH PHẪU THUẬT TRIỆT CĂN TẠI BỆNH VIỆN U BƯỚU HÀ NỘI
Authors: Chu Văn Tuynh , Phạm Văn Thái 
Published: July 2024

Mục đích: Nhận xét một số đặc điểm lâm sàng, đặc điểm tập trung 18FDG của u và hạch trên PET/CT ở bệnh nhân ung thư phổi không tế bào nhỏ có chỉ định phẫu thuật triệt căn tại bệnh viện U bướu Hà Nội. Đối tượng và phương pháp: 82 bệnh nhân ung thư phổi không tế bào nhỏ nguyên phát, được chụp 18FDG PET/CT trước phẫu thuật.
Kết quả: U phổi phải 64,6%; u phổi trái 35,4%. Kích thước trung bình của u là 2,6 ± 1,0 cm, bệnh nhân với hạch (+) trên PET/CT có kích thước u phổi trung bình là 3,3 ± 0,9cm; lớn hơn so với bệnh nhân có hạch N0 (p <0,05). SUVmax trung bình của u phổi là 6,0 ± 4,5 và tăng theo kích thước u (tương quan thuận, r=0,58). U ≤2cm, SUVmax = 4,1 ± 2,1. U >2-3cm, SUVmax = 5,3 ± 3,6 và U >3 -5cm, SUVmax = 8,3 ± 4,9. SUVmax tăng theo giai đoạn bệnh và cao hơn ở những bệnh nhân có hạch dương tính trên PET/CT.
Kết luận: 18FDG PET/CT có vai trò quan trọng trong chẩn đoán ung thư phổi không tế bào nhỏ. SUVmax là thông số định lượng liên quan đến kích thước u, tình trạng hạch và giai đoạn bệnh.
VAI TRÒ CỦA PET/CT TRONG UNG THƯ VÚ
Authors: Nguyễn Huỳnh Khánh An , Võ Khắc Nam 
Published: July 2024

Giới thiệu: Ung thư vú là ung thư hàng đầu ở nữ giới. Chârn đoán chính xác giai đoạn giúp điều trị bệnh nhân một cách hiệu quả và có thể kéo dài thời gian sống cho bệnh nhân. PET/CT là một phương tiện hiệu quả trong chẩn đoán và phân lập giai đoạn ung thư vú.
Mục tiêu: Nghiên cứu này đánh giá mức độ thay đổi giai đoạn của ung thư vú sau khi chụp PET/CT, đồng thời đánh giá mức độ hấp thu FDG theo chỉ số SULmax của các tổn thương.
Đối tượng và phương pháp: Đối tượng nghiên cứu là các bệnh nhân ung thư vú chụp PET/CT trong năm 2020. Những bệnh nhân đươc loại khỏi nghiên cứu gồm những bệnh nhân rơi vào các tình huống sau: ung thư vú 2 bên, có các bệnh ung thư khác, thiếu các thông tin về giai đoạn bệnh, đường huyết khi tiêm phóng xạ lớn hơn 200 mg/dL. Liều FDG dùng cho các bệnh nhân là 0,1mCi/ kg cân nặng. Chụp PET/CT sacn từ đỉnh đầu đến 1/3 trên đùi. Dữ liệu được ghi nhận trước và sau khi chụp. Xử lý dữ liệu với MS Excel và SPSS 25.0. Phương pháp nghiên cứu: hồi cứu, mô tả hàng loạt ca
Kết quả: Sau khi sàng lọc, có 80 bệnh nhân được chọn vào nghiên cứu. Trong đó, 47,5% là các trường hợp ung thư vú trái và 52,5% là các ung thư vú phải. Mục đích chụp PET/CT có 33,8% chụp để chẩn đoán giai đoạn và phần lớn còn lại để đanh giá tái phát, di căn. Sự thay đổi giai đoạn sau chụp PET/CT được ghi nhận là 47,5% với 45% tăng giai đoặn và 2,5% giảm giai đoạn. Khi đánh giá mức độ hấp thu FDG theo SULmax ghi nhận các bướu nguyên phát cho hấp thu cao nhất. Trong các phân nhóm sinh học, phân nhóm tam âm có mức hấp thu trung bình cao nhất. Về các tổn thương di căn phát hiện được thì di căn phổi – màng phổi chiếm tỉ lệ cao nhất với 38,25%. Ngoài ra, còn phát hiện 26,27 % các trường hợp di căn từ hai vị trí trở lên.
Kết luận: PET/CT đã giúp cho gần một nửa số bệnh nhân được phân loại giai đoạn chính xác và nhận được điều trị đúng mức. Đồng thời các bệnh nhân còn lại cũng được an tâm điều trị theo chiến lược hiện tại. PET/CT còn giúp đánh giá mức độ chuyển hoá glucose của các tổn thương ác tính hoặc phát hiện sớm các tổn thương tái phát, di căn khi chưa có thay đổi về hình thái.
Paramedics’ Anxiety and Concerns Towards Attending Traumatic Events
Authors: Alshamrani Abdullah , Cameron M  , Alzobaidi Sultan , Khasawneh Eihab , Williams Brett 
Published: July 2024

Introduction
Trauma is a major problem in Saudi Arabia and a leading cause of mortality and morbidity in young age groups. In 2018, road traffic injuries and trauma were the second-leading cause of death after ischaemic heart disease. There is a lack of research that explores the psychological effects on emergency medical service (EMS) professionals of providing the required pre-hospital care for trauma cases. This study aims to identify which trauma cases cause the most anxiety and concern among a group of EMS professionals.
Methods
A study using a two-round Delphi method was undertaken online with EMS professionals working for the Saudi Red Crescent Authority (SRCA) across the country.
Results
The response rate was 70% (n=14) at the end of round two. All participants were male and the majority of professionals who participated were from the capital city, representing 36%. Most of the professionals held a bachelor’s degree as the highest level of education (78%). The initial round generated one item that achieved 70% of the consensus; however, the second round did not achieve any consensus. The overall top item for the trauma cases that caused the most anxiety and concern as identified by respondents was road traffic collision.
Conclusion
Road traffic collisions are a leading cause of death and based on the respondents’ agreement they cause paramedics the most anxiety and concern of the cases they attend.
Assessment and Empirical Treatment of Chronic Abdominal Pain from Suspected Helicobacter Pylori Infection In a Remote Setting
Authors: Ferguson Sean 
Published: July 2024

The prevalence of Helicobacter Pylori (H. Pylori) remains globally high, with an estimated 50% of the words population believed to be infected. Despite the continually high incident rates of infection 90% of those infected remain asymptomatic. H.Pylori is a gram-negative, microaerophilic bacteria, mostly found in stomach of affected individuals that causes inflammation and ulceration.
Definitive routes of transmission and subsequent infection are still debated. The most likely mechanism of transmission is thought to be intrafamilliar, this encapsulates fecal-oral, gastric-oral, oral-oral and sexual vectors. Contaminated foods and water sources are also highly likely mechanisms of transmission. Therefore in developing countries with poor sanitation, potentially contaminated water sources and regions with social-economic hardship experience increased symptomatic cases of H.Pylori.
Το Προσωπικό Ταξίδι της Ανθής Αγρότου Μέσα από την Ανέλιξη της Μουσικοθεραπείας στην Κύπρο – Ανθή Αγρότου, μια συνέντευξη από τη Δώρα Παυλίδου
Authors: Αγρότου Ανθή , Παυλίδου Δώρα 
Published: July 2024

Αυτή η συνέντευξη επικεντρώνεται στο προσωπικό ταξίδι της Δρ. Ανθής Αγρότου, η οποία ξεδιπλώνει τις εμπειρίες που έχει βιώσει σε μια εποχή όπου η μουσικοθεραπεία στην Κύπρο βρισκόταν σε αρχικά στάδια της εξέλιξής της. Περιγράφει πώς η ίδια κατέληξε στο χώρο της μουσικοθεραπείας και αναφέρει σημαντικούς σταθμούς στην επαγγελματική της πορεία. Παράλληλα σηματοδοτεί τα εφόδια που έχει χρησιμοποιήσει και αποκτήσει κατά την επαγγελματική της σταδιοδρομία, ενώ προσφέρει συμβουλές για την περαιτέρω ανάπτυξη της μουσικοθεραπείας στην Κύπρο.
Terjemah Al-Qur'an pada Q.S Al-Mulk
Authors: Saputra Akhmadiyah , Nurdi Annisa Rashifa Hani' 
Published: July 2024

Di era modern ini, ilmu berkembang sangat pesat, terutama di bidang ilmu pengetahuan dan teknologi sehingga berpengaruh pada bidang pembelajaran Al-Qur'an. Banyak pihak yang membuat berbagai macam aplikasi Al-Qur'an dengan disertai terjemahannya yang sangat mudah untuk diakses oleh masyarakat, seperti ELFAN Bookless Library System. Penelitian ini bertujuan untuk mengetahui metode terjemah yang digunakan dalam Al-Qur'an dan Terjemahnya karya Kementerian Agama Republik Indonesia dan Al-Qur'an dan Terjemahnya dalam Teknologi Kepustakaan ELFAN Bookless Library System juga persamaan dan perbedaan keduanya. Pendekatan yang dilakukan dalam penelitian ini adalah pendekatan komparatif dengan jenis penelitian kepustakaan (library research).
Hasil analisa dari penelitian ini adalah pertama, metode terjemah yang digunakan sama, yaitu metode terjemah harfiyyah. Kedua, persamaan antara kedua Al-Qur'an terletak pada metode penerjemahan dan beberapa tanda baca yang masih salah digunakan dalam terjemah Surat al-Mulk. Sedangkan perbedaan terjemah dari kedua Al-Qur'an tersebut terletak pada susunan struktur kalimat, penulisan kata penghubung, penulisan kalimat efektif, penulisan tanda baca dan perbedaan makna dari masing-masing terjemah.
Pengaruh Harga Produk, Customer Review Dan Preferensi Pengalaman Pembelian Terhadap Keputusan Pembelian Mahasiswa Manajemen Upgris Pada Shopee Dan TikTok Shop
Authors: Welly Dhea Ayu Hapsari  , Rizky Fatkhur Rohman  , Yunia Nur Anisa  , Rauly Sijabat  
Published: July 2024

This research aims to analyze the influence of product prices and customer reviews on purchasing decisions of Management students at PGRI University Semarang (Upgris) on the e-commerce platforms Shopee and TikTok Shop. In the current digital era, e-commerce has become one of the main channels for consumers to make purchases. Two important factors that consumers often consider before making a purchase are product price and customer reviews. The research method used is quantitative with a survey approach. Data was collected through a questionnaire distributed to 36 Upgris Management students who actively use Shopee and TikTok Shop.The research results show that both product price and customer reviews have a significant influence on purchasing decisions. Specifically, product price has a greater influence than customer reviews in determining purchasing decisions on both platforms. Apart from that, there is a difference in the level of trust in customer reviews on Shopee and TikTok Shop, where students tend to trust reviews on Shopee more. It is hoped that these findings will provide insight for e-commerce businesses in designing effective marketing strategies by considering price factors and customer reviews.
Megumi Chaksu: Sebuah Transformasi Kecantikan Sinar Matahari Dalam Bentuk Karya Tari
Authors: Devi Putu Rismayuni , Sariada I Ketut , Satyani Ida Ayu Wayan Arya 
Published: July 2024

Tari Megumi Chaksu adalah sebuah tari kreasi baru dengan menjadikan Amaterasu, Dewi Matahari dalam Mitologi Jepang sebagai sumber kreatif penciptaan. Penata mencoba mentransformasikan mengenai akulturasi budaya antara Jepang dan Bali dengan mengimplementasikan sudut pandang penata dalam hal gerak, musik, tata rias, dan tata busana. Penciptaan Tari Megumi Chaksu menggunakan metode penciptaan Panca Sthiti Ngawi Sani yang dibuat oleh Prof. Dr. I Wayan Dibia, SST, MA. yang meliputi: Ngawirasa, Ngawacak, Ngarencana, Ngawangun, dan Ngebah. Tari ini dibawakan secara kelompok dengan karakter putri halus menggunakan 7 orang penari perempuan dengan struktur tari, bagian 1 menggambarkan kecantikan Amaterasu, bagian 2 menggambarkan sinar matahari yang dipancarkan oleh Amaterasu, dan bagian 3 menggambarkan pemujaan terhadap Amaterasu. Durasi karya ini adalah 11 menit dengan menggunakan pendekatan persandingan laras utama pada gamelan Semarandana yang dikolaborasikan dengan beberapa instrumen Jepang dan efek dari sample bunyi dengan media aplikasi Musical Instrumen Digital Interface (MIDI). Menggunakan tata rias dan tata busana dari perpaduan antara Jepang dan Bali. Properti payung dan kipas panjang led juga sangat berperan penting untuk mendukung kesuksesan dan menunjang estetika dari karya Tari Megumi Chaksu.
Az INSARAG irányelvek érvényesülése a HUNOR mentőcsapat működésében a 2023-as törökországi földrengések során
Authors: Varró Tekla , Muhoray Árpád 
Published: July 2024

A 2023. február 6-án Törökországot és Északnyugat-Szíriát megrázó földrengés kárfelszámolása nemzetközi segítséget igényelt, tekintettel a káreset nagyságára, az esemény bonyolultságára, és a kiterjedésére. Magyarország a nemzetközileg bevethető, nehéz kategóriás hivatalos mentőcsapatát, a HUNOR-t küldte a helyszínre, majd őket követték önkéntes mentőszervezetek, a TEK speciális csapatai, katonaorvosok és statikus mérnökök is. A szerzők az INSARAG Irányelvek előírásainak megfelelő mentési tevékenységet vizsgálják, melyet a HUNOR mentőcsapatnak is kötelező betartani, hiszen ENSZ INSARAG nehéz kutató mentőcsapatként szereztek minősítést. A Törökország nemzetközi segítségkérésétől, a mentőcsapatok ország elhagyásáig felölelő időszakban felállított ad-hoc jellegű munkacsoportok, a mentésben részt vevő egységek, valamint az INSARAG szervezetének vizsgálata adja a cikk gerincét. A téma aktuális, hiszen az ENSZ INSARAG a világ bármely táján bekövetkező katasztrófa esetén segítséget nyújt, amennyiben a bajba jutott ország kéri azt. A cikk végén a szerzők kitérnek Magyarország földrengés veszélyeztetettségének vizsgálatára, majd javaslatot tesznek a lakosság felkészítésének újabb, ezidáig még kiaknázatlan lehetőségeire. A javaslatok között szerepel a VÉSZ applikáció fejlesztési lehetősége, a hivatásos katasztrófavédelem honlapjának új modullal történő fejlesztésének lehetősége, a tájékoztató kiadványok földrengés témában történő bővítési lehetősége, valamint gyermekek számára zsebre tehető földrengési kisokos létrehozásának lehetősége.
Fear of COVID-19 and Financial Sector of Tadawul Stock Exchange
Authors: Fraz Dr Ahmed 
Published: July 2024

The objective of this study is to analyse the effect of the COVID-19 outbreak on the financial sector's equity returns, specifically focusing on Sukuk & Bonds (TSBI), Diversified Financials (TDFI), Banks (TBNI), Insurance (TISII), and the Tadawul All Share (TASI) Index. This will be done through the utilisation of t-test and event study technique. The event will take place from December 2018 to March 2020. The estimation period covers the time frame from December 2018 to December 2019. The pre-announcement phase of the WHO notice spans the month of January 2020, while the post-announcement phase encompasses February 2020 to March 2020. The study suggests that, prior to the alarm given by the WHO, the majority of the financial sector exhibits positive returns, with the exception of Banks. The results validate the substantial and adverse influence of the COVID-19 epidemic on Diversified Financials (TDFI), Banks (TBNI), and Insurance (TISII) following the global alert notice by the World Health Organisation (WHO). The study indicates that the Sukuk & Bonds (TSBI) sector has remained unaffected by the epidemic and has shown a favourable influence on returns. This industry provides a fixed interest rate and does not influence the expectations of investors. Saudi Arabia's government announced a stimulus package of $18.7 billion on March 20, 2020. The adverse consequences suggest that the policymakers failed to foresee this issue and did not take timely action. This study recommends that effective policies must be designed by the policymakers in anticipation of such pandemic outbreak that may help the investors to devise diversification strategies.
Photoelectrocatalysis Activity TiO2/Ti electrode doped with N and Ni deposition for Congo Red Degradation
Authors: Edihar Muh , Irwan Irwan , Lidong Andini 
Published: July 2024

The TiO2/Ti electrode was successfully synthesized by combining element N and metal Ni on the TiO2 matrix to degrade the organic compound Congo Red under UV-visible radiation. The aim of this study is to obtain Ni@N-TiO2/Ti electrodes and test their performance in degrading Congo Red dye under UV-visible light radiation. The Ni@N-TiO2/Ti electrode was prepared using the Sol-Gel and electrodeposition methods. The presence of nitrogen in N-TiO2 is determined by FTIR and detected at a wavelength of 1.064 cm1. The analysis of UV-Vis DRS indicates an energy gap of 3.06 eV for N-TiO. XRD analysis revealed anatase crystal structure formation and nickel's presence in the Ni@N-TiO2/Ti electrode detected at 2θ 52.8°. The usage characteristics of linear sweep voltammetry indicate that the TiO2/Ti electrode is active under UV light, while the Ni@N-TiO2/Ti electrode is active under visible light. An electrode activity test using the multi-pulse amperometry method showed that the photoelectrocatalysis performance of Ni@N-TiO2/Ti under visible light radiation reached an ideal degradation rate of 36%.
Sleep Disorders and Quality of Life of Women in Menopausal Transition and Postmenopausal Assisted in Primary Health Care: A Cross-Sectional Observational Study Protocol
Authors: Ribeiro Leandro Victor Silva , Pasqualotto Luísa Teixeira , Júnior Newton Santos de Faria 
Published: July 2024

Aims: The objective of the study will be to evaluate the presence of sleep disorders, sleep quality and life of women in the menopausal transition and postmenopausal assisted in primary health care (PHC) in Divinópolis/MG.
Study Design: Cross-sectional observational.
Place and Duration of Study: PHC in the municipality of Divinópolis, Minas Gerais, Brazil, between January and December 2023.
Material and Methods: The present study will be carried out by professors and students of the University of the State of Minas Gerais (UEMG), Divinópolis Unit, with women recruited from PHC in the municipality of Divinópolis/MG, after consenting to participate in the study, by signing the Informed Consent Form (ICF). The sample will be consecutive and of convenience and then stratified according to sociodemographic variables, presence or absence of sleep disorders, sleep quality, quality of life and other variables pertinent to the study.
Discussion: Due to the lack of professional performance in primary care for sleep disorders, it is necessary to study the concomitant changes between the menopausal transition and postmenopausal processes. Given the aspects related to these disorders, there is a need for a more in-depth look at the factors that can interfere with sleep quality during this transition.
Conclusion: This study protocol aims to investigate sleep disorders and the quality of sleep and life in women during the menopausal and postmenopausal transition phases. The research seeks to identify data demonstrating the changes that occur during these phases.
Multiple jobholder mortality patterns in Kentucky: An examination of occupational fatalities
Authors: Bush Ashley M. , McKee Sarah E. , Bunn Terry L. 
Published: May 2013

AbstractBackgroundThe percentage of multiple jobholders was elevated in Kentucky compared to the US from 2002 to 2010.MethodsKentucky Fatality Assessment and Control Evaluation (FACE) multiple jobholder fatality data were analyzed to identify contributing injury factors from 2002 to 2010.ResultsKentucky's total occupational fatality rates were higher than US rates for all years (2002–2010). Kentucky multiple jobholder fatalities averaged 8.4 deaths per 100,000 employees compared to the total average occupational fatality rate of 6.5. Almost half of multiple jobholder fatalities (47%) occurred in the agricultural industry and management occupation as the primary industry and occupation; 67% were tractor‐related. The most prevalent secondary industry and occupation were the construction industry and management occupation.ConclusionsIncreased surveillance of multiple jobholder injuries is needed to improve safety and health on the job. Future investigations should include the relationship between multiple jobholding and agricultural employment as farm owners. Am. J. Ind. Med. 56:881–888, 2013. © 2013 Wiley Periodicals, Inc.
Convergent functional genomics of psychiatric disorders
Authors: Niculescu Alexander B. 
Published: May 2013

AbstractGenetic and gene expression studies, in humans and animal models of psychiatric and other medical disorders, are becoming increasingly integrated. Particularly for genomics, the convergence and integration of data across species, experimental modalities and technical platforms is providing a fit‐to‐disease way of extracting reproducible and biologically important signal, in contrast to the fit‐to‐cohort effect and limited reproducibility of human genetic analyses alone. With the advent of whole‐genome sequencing and the realization that a major portion of the non‐coding genome may contain regulatory variants, Convergent Functional Genomics (CFG) approaches are going to be essential to identify disease‐relevant signal from the tremendous polymorphic variation present in the general population. Such work in psychiatry can provide an example of how to address other genetically complex disorders, and in turn will benefit by incorporating concepts from other areas, such as cancer, cardiovascular diseases, and diabetes. © 2013 Wiley Periodicals, Inc.