bluuebunny/crossref_metadata_2025_split huggingface dataset:
Decoying the enemy: soluble receptor for advanced glycation end products and cognitive impairment in neurodegenerative diseases—a systematic review and meta-analysis
Authors: Mahayana Ngakan Putu Krishna , Yadmika Ni Putu Wulandari Putri , Aryaweda Made Dhiyo Wiweka , Mahardana Made Dwinanda Prabawa , Mamangdean Christo Timothy , Dewi Ni Nyoman Ayu , Wirawan Chandra , Laksmidewi Anak Agung Ayu Putri 
Published: August 2024

Abstract
Background
Accumulation of advanced glycation end products (AGEs) has contribution in development of Alzheimer’s disease (AD), vascular dementia (VAD), and mild cognitive impairment (MCI). AGEs activate several signaling pathways that have roles in development of those diseases via receptor for advanced glycation end product (RAGE), this receptor has its soluble form called sRAGE which has ability to bind AGEs but could not induce molecular signaling. Based on this property, sRAGE could work as RAGE decoy and prevent pathological effect of AGEs accumulation. This meta-analysis is aimed to evaluate correlation between sRAGE plasma level and risk of AD, VAD, and MCI.

Methods
Standardized mean difference with 95% coincidence interval was used as effect size. Inverse variance was used as analysis method with random effect model. Egger test and funnel plot were used to assess publication bias.

Results
We found 424 articles through database searching. Among those articles, 15 articles that fulfilled our eligibility criteria. After selection based on inclusion and exclusion criteria, only 5 articles were included in this meta-analysis. Our analysis found that AD and VAD patients have lower levels of plasma sRAGE when compared to healthy control. Significant correlation between low sRAGE plasma level and MCI was not found. However, publication bias is found in MCI group. Publication bias of VAD group could not be assessed due to limited number of studies.

Conclusions
Here, we show inverse relationship between sRAGE and the incidence of AD alongside VAD suggests that lower sRAGE plasma levels may be associated with a higher incidence of AD and VAD. However, some limitations in sample size and minimal studies may introduce bias into our results.
Knowledge, perceived benefits, perceived concerns, and predisposition to use telehealth services in Bangladesh: a cross-sectional survey
Authors: Kabir Humayun , Hasan Md. Kamrul , Jamil Safayet , Chowdhury Saifur R. , Mitra Dipak Kumar 
Published: August 2024

Abstract
Background
Telehealth services are essential to expand healthcare coverage for all in the era of modern technology. Knowledge, willingness, and involvement with the service are also significantly important in the utilization of the service. This study investigated factors associated with knowledge, perceived benefits, perceived concerns, and predisposition to use telehealth services in Bangladesh. This web-based survey was conducted among 1266 adults in Bangladesh. Respondents were enrolled by following a convenience sampling technique.

Results
Demographic, telehealth service, and perceived health related information were significantly associated with respondents’ knowledge, perceived benefits, perceived concerns, and predispositions. The knowledge was significantly positively correlated with the perceived benefit (p <0.05) and predisposition of telehealth (p <0.05). Albeit, knowledge was significantly negatively correlated with perceived concerns of telehealth (p <0.05).

Conclusion
The findings of the study may assist policymakers in implementing telehealth services by addressing the associated factors of knowledge, perceived benefits, perceived concerns, and predispositions.
Challenges to the real-world delivery of brief alcohol interventions in the custody suite: qualitative study
Authors: Jarrett Manuela , Mills Thomas , Mallion Jaimee , Sykes Susie , Wills Jane , Chaplin Eddie 
Published: August 2024

Aims and methodThe aim was to evaluate an innovative pathway in police custody suites that aimed to specifically address alcohol-related health needs through screening and brief interventions by police custody staff. This paper presents a qualitative investigation of challenges involved in implementing the pathway. Qualitative interviews were carried out with 22 staff involved with commissioning and delivering the pathway; thematic analysis of interview data was then undertaken.ResultsAn overarching theme highlights the challenges and uncertainties of delivering brief alcohol interventions in the custody suite. These include challenges related to the setting, the confidence and competence of the staff, identifying for whom a brief intervention would be of benefit and the nature of the brief intervention.Clinical implicationsOur findings show that there is a lack of clarity over how alcohol-related offending can be identified in police custody, whose role it is to do that and how to intervene.
Natural Language Processing Accurately Differentiates Cancer Symptom Information in Electronic Health Record Narratives
Authors: Albashayreh Alaa , Bandyopadhyay Anindita , Zeinali Nahid , Zhang Min , Fan Weiguo , Gilbertson White Stephanie 
Published: August 2024

PURPOSE Identifying cancer symptoms in electronic health record (EHR) narratives is feasible with natural language processing (NLP). However, more efficient NLP systems are needed to detect various symptoms and distinguish observed symptoms from negated symptoms and medication-related side effects. We evaluated the accuracy of NLP in (1) detecting 14 symptom groups (ie, pain, fatigue, swelling, depressed mood, anxiety, nausea/vomiting, pruritus, headache, shortness of breath, constipation, numbness/tingling, decreased appetite, impaired memory, disturbed sleep) and (2) distinguishing observed symptoms in EHR narratives among patients with cancer. METHODS We extracted 902,508 notes for 11,784 unique patients diagnosed with cancer and developed a gold standard corpus of 1,112 notes labeled for presence or absence of 14 symptom groups. We trained an embeddings-augmented NLP system integrating human and machine intelligence and conventional machine learning algorithms. NLP metrics were calculated on a gold standard corpus subset for testing. RESULTS The interannotator agreement for labeling the gold standard corpus was excellent at 92%. The embeddings-augmented NLP model achieved the best performance (F1 score = 0.877). The highest NLP accuracy was observed in pruritus (F1 score = 0.937) while the lowest accuracy was in swelling (F1 score = 0.787). After classifying the entire data set with embeddings-augmented NLP, we found that 41% of the notes included symptom documentation. Pain was the most documented symptom (29% of all notes) while impaired memory was the least documented (0.7% of all notes). CONCLUSION We illustrated the feasibility of detecting 14 symptom groups in EHR narratives and showed that an embeddings-augmented NLP system outperforms conventional machine learning algorithms in detecting symptom information and differentiating observed symptoms from negated symptoms and medication-related side effects.
Toward a Framework to Assess the Financial and Economic Burden of Cervical Cancer in Low- and Middle-Income Countries: A Systematic Review
Authors: Fuady Ahmad , Setiawan Didik , Man Irene , de Kok Inge M.C.M. , Baussano Iacopo 
Published: August 2024

PURPOSE To review the economic burden assessment of cervical cancer in low- and middle-income countries (LMICs) and use the findings to develop a pragmatic, standardized framework for such assessment. METHODS We first systematically reviewed articles indexed in scientific databases reporting the methodology for collecting and calculating costs related to the cervical cancer burden in LMICs. Data on study design, costing approach, cost perspective, costing period, and cost type (direct medical costs [DMC], direct nonmedical costs [DNMC], and indirect costs [IC]) were extracted. Finally, we summarized the reported limitations in the methodology and used the solutions to inform our framework. RESULTS Cervical cancer treatment costs across LMICs vary greatly and can be extremely expensive, up to 70,968 International US dollars. Economic and financial assessment methods also vary greatly across countries. Of the 28 reviewed articles, 25 studies reported DMC for cervical cancer treatment by extracting cost information from billing or insurance databases (eight studies), conducting surveys (five), and estimating the costs (12). Only 11 studies—mainly through surveys—reported DNMC and IC. The economic burden assessment framework includes health care/payer and societal perspectives (DMC, DNMC, IC, and human capital loss) across the cervical cancer screening and treatment continuum. To assess health care/payer costs, we recommend combining the predefined treatment standards with actual local treatment practices, multiplied by unit costs. To assess societal costs, we recommend conducting a cost survey in line with a standardized yet adaptable protocol. CONCLUSION Our standardized, pragmatic framework allows assessment of economic and financial burden of cervical cancer in LMICs despite the different levels of available resources across countries. This framework will facilitate global comparisons and monitoring and may also be applied to other cancers.
Strategy to Improve the Oral Pharmacokinetics of Cyclin-Dependent Kinase 4/6 Inhibitors: Enhancing Permeability and CYP450 Inhibition by a Natural Bioenhancer
Authors: Patil Prajakta Harish , Desai Mrunal Pradeep , Rao Rajat Radhakrishna , Mutalik Srinivas , Puralae Channabasavaiah Jagadish 
Published: August 2024

AbstractPalbociclib and ribociclib an orally bioavailable, potent cyclin-dependent kinase 4/6 inhibitors, with low oral bioavailability due to substrate specificity towards CYP3A and P-glycoprotein. Thus, current research aims to examine the effect of a bioenhancer (naringin), on oral pharmacokinetics of palbociclib and ribociclib. Naringin’s affinity for CYP3A4 and P-glycoprotein was studied using molecular docking; its impact on palbociclib/ribociclib CYP3A metabolism and P-glycoprotein-mediated efflux was examined using in vitro preclinical models; and its oral pharmacokinetics in rats were assessed following oral administration of palbociclib/ribociclib in presence of naringin (50 and 100 mg/kg). Naringin binds optimally to both proteins with the highest net binding energy of − 1477.23 and − 1607.47 kcal/mol, respectively. The microsomal intrinsic clearance of palbociclib and ribociclib was noticeably reduced by naringin (5–100 µM), by 3.0 and 2.46-folds, respectively. Similarly, naringin had considerable impact on the intestinal transport and efflux of both drugs. The pre-treatment with 100 mg/kg naringin increased significantly (p < 0.05) the oral exposure of palbociclib (2.0-fold) and ribociclib (1.95-fold). Naringin's concurrent administration of palbociclib and ribociclib increased their oral bioavailability due to its dual inhibitory effect on CYP3A4 and P-glycoprotein; thus, concurrent naringin administration may represent an innovative strategy for enhancing bioavailability of cyclin-dependent kinase inhibitors.
Graphical Abstract
A Small Opening in the Storm Clouds: Overview of the Registry-based Study on the Management of Thyroid Storm
Authors: Duntas Leonidas H , Zarkovic Milos 
Published: August 2024

Abstract
Because of the high mortality rate of thyroid storm (TS), effective guidance for its diagnosis and treatment is essential. The diagnostic criteria introduced by the Japanese Thyroid Association in 2012, along with the Burch-Wartofsky Point Scale, constitute valuable tools for the diagnosis of TS. In 2016, Guidelines on the management of TS were produced by the Japanese Thyroid Association and the Japanese Endocrine Society. Recently, a prospective multicenter register-based study compared the prognosis and outcome of 110 new-onset TS patients with the results of previous comparable studies and evaluated the efficacy of the Guidelines. The study revealed higher Acute Physiology and Chronic Health Evaluation II scores and significant correlations between lower body mass index, postresuscitation shock, and fever with outcomes and, overall, improved TS prognosis. Most patients in the study received methimazole and potassium iodide, the timely administration of which was linked to lower fatality rates. Adherence to treatment guidelines correlates with lower mortality rates, emphasizing the importance of experienced multidisciplinary teams in intensive care unit settings and the necessity for periodic review of the guidelines to enhance therapeutic approaches and reduce mortality.
Aneurysm Wall Enhancement Can Predict Rupture Point in Intracranial Aneurysms With Multiple Blebs
Authors: Omodaka Shunsuke , Sugiyama Shin-ichiro , Sakata Hiroyuki , Funamoto Kenichi , Yamaguchi Takuhiro , Niizuma Kuniyasu , Endo Hidenori 
Published: August 2024

BACKGROUND AND OBJECTIVES:
Ruptured aneurysms visualized by vessel wall MRI (VW-MRI) exhibit characteristic aneurysm wall enhancement (AWE). A secondary bulge of the aneurysmal wall, called a bleb, is often the site of rupture in ruptured aneurysms. We hypothesized that a higher degree of AWE would identify the rupture point in aneurysms with multiple blebs.

METHODS:
AWE was quantitatively analyzed in consecutive ruptured intracranial aneurysms with multiple blebs (31 aneurysms with a total of 72 blebs) using VW-MRI. A 3-dimensional T1-weighted fast spin-echo sequence was obtained after contrast media injection, and the contrast ratio of the aneurysm wall against the pituitary stalk (CRstalk) was calculated as the AWE indicator. Bleb characteristics, including CRstalk and wall shear stress (WSS), were compared between ruptured and unruptured blebs. Odds ratios with 95% confidence intervals for ruptures were calculated by conditional logistic regression analysis.

RESULTS:
Ruptured blebs had a higher CRstalk and lower WSS compared with unruptured blebs. CRstalk remained significantly associated with the bleb rupture status in the conditional logistic regression (adjusted odds ratio 3.9, 95% CIs 1.6-9.7).

CONCLUSION:
AWE is associated with the bleb rupture status independent of WSS. Contrast-enhanced VW-MRI may be a useful noninvasive tool for identifying the rupture point and guiding the treatment strategy.
STANDARD AND BIOPSYCHOSOCIAL OSTEOPATHIC MANAGEMENT FOR PATIENTS WITH NON-SPECIFIC LOW BACK PAIN (THE OSCAR STUDY): A SINGLE-CASE EXPERIMENTAL DESIGN
Authors: Draper-Rodi J , Abbey H , Brownhill K , Vogel S 
Published: August 2024

Purpose and BackgroundGuidelines recommend biopsychosocial care for chronic, complex musculoskeletal conditions, including non-specific low back pain. The aims were: 1/ to assess how patients with low back pain respond to osteopathic treatment, both before and after an osteopath has completed a Biopsychosocial Pain Management (BPM) course; and 2/ to assess if it is feasible and acceptable for osteopath participants to receive weekly SCED data and use it to guide patient management.Methods and ResultsA multiple baseline single case experimental design trial (clinicaltrials.gov, on 18/10/2021, ID number NCT05120921) with 11 UK osteopaths was conducted. Patients were randomised to early, middle or late treatment start dates. Statistical analysis assessed the change between baseline, intervention and follow-up periods. Primary outcomes were the Numeric Pain Rating (NPR) and Patient Specific Function Scales (PSFS), measured during the baseline, the 6-week intervention, and during a 12-week follow-up period.At baseline, the osteopaths reported stronger biopsychosocial attitudes to pain, compared to biomedical beliefs (PABS: 34 behavioural scale; 29 biomedical scale). Overall, patient participants showed daily increases in symptoms during the pre-treatment phase (+0.24/day, p<0.001), and daily decreases during treatment (−2.94 over the treatment phase, p<0.001), which continued post-treatment (−3.36 over 12 weeks, p=0.04). Similar improvements were observed for function.ConclusionOsteopathic care was shown to help patients with persistent low back pain. Patient recruitment was challenging because of the randomisation. With further development, the method shows feasibility as a means of enhancing research activity among practising clinicians.Previous presentations or publications of the workThe protocol was published (https://doi.org/10.1016/j.ijosm.2023.100660) and presented at SBPR in 2022. The results were presented to an osteopathic conference in October 2023.Ethics approval was received from the University College of Osteopathy Research Ethics Committee.Conflicts of interestsJerry Draper-Rodi receives fees from the sales of the e-learning course on the biopsychosocial management on the UCO CPD platform.Sources of fundingThe research was funded by the Osteopathic Foundation.
CONTRASTING CULTURES OF EMERGENCY DEPARTMENT CARE: A QUALITATIVE STUDY OF PATIENTS’ EXPERIENCES OF ATTENDING THE EMERGENCY DEPARTMENT FOR LOW BACK PAIN
Authors: Ryan C. , Pope C.J. , Roberts L.C. 
Published: August 2024

Purpose and backgroundAlthough clinical guidelines recommend that low back pain (LBP) is best managed in primary or community care, in the UK and globally, LBP accounts for around 4% of emergency department (ED) attendances. Organising and delivering healthcare to be safe, effective, and acceptable requires hearing patients’ perspectives; this study therefore aimed to explore patients’ experiences of attending the ED for LBP.Methods and resultsThis was a multisite qualitative interview study with 47 adults (aged 23–79 years) who, in the past six weeks, had attended one of four UK NHS emergency departments for LBP (all types and durations). Purposive sampling was used to gain variation in the recruiting site, and LBP and demographic characteristics. Data were collected using individual, semi-structured, telephone interviews (median 45mins). Interviews were audio-recorded, transcribed verbatim, and analysed thematically.We identified significant variation in patients’ experiences of ED care for LBP, which we argue reflects contrasting cultures of ED care. We present three cultures, emergency screening only, ‘cynicism and neglect’, and ‘kindness’; these cultures differ in how they navigate the tension between the ED remit and patients’ perceived needs of care. We draw on Bourdieu's notions of field and habitus and professional identity theory to help explain these findings.ConclusionOur findings suggest unwarranted variation in ED care for LBP. Implications include the need for urgent access to primary and community care and clarity about best practice managing LBP in the ED; best practice guidance and strategies to implement this should be informed by notions of culture and professional identity.No conflicts of interest Sources of fundingHealth Education England & National Institute of Health and Care Research (ICA-CDRF-2018-04-ST2-040)
Cluster-based unsupervised method for eavesdropping detection and localization in WDM systems
Authors: Song Haokun , Lin Rui , Wosinska Lena , Monti Paolo , Zhang Mingrui , Liang Yuyuan , Li Yajie , Zhang Jie 
Published: August 2024

Ensuring the secure and reliable operation of optical networks is crucial for various societal functions. However, optical network infrastructures are susceptible to unauthorized interception, posing a significant security risk at the physical layer. This necessitates the development of effective detection and localization methods of eavesdropping events. To address this challenge, we present a clustering-based method and a comprehensive eavesdropping diagnosis framework tailored for wavelength division multiplexing (WDM) systems. The framework is designed to handle diverse eavesdropping scenarios, including dynamic detection, classification, and localization of eavesdropping events. To mitigate the data dependency issue while detecting and localizing eavesdropping events, we propose a clustering algorithm utilizing basic optical performance monitoring (OPM) data, thus eliminating the need for sophisticated measurement equipment. A coarse localization requires only the OPM data from the receiver, while a finer localization requires the power monitoring data at all nodes as the input. The feasibility of the proposed scheme is validated using simulation-generated data, in which single and multiple eavesdropping can be detected and localized with a 100% label matching rate. Single-point eavesdropping detection and localization are experimentally validated with data collected from a fiber transmission system comprising three spans of 40 km each. Coarse localization with a 99.79% label matching rate and fine localization with 100% accuracy is achieved. As expected, experimental data shows a less concentrated distribution than the simulated data, which leads to inferior clustering results.
How to find optimal quantum states for optical micromanipulation and metrology in complex scattering problems: tutorial
Authors: Rachbauer Lukas M. , Bouchet Dorian , Leonhardt Ulf , Rotter Stefan 
Published: August 2024

The interaction of quantum light with matter is of great importance to a wide range of scientific disciplines, ranging from optomechanics to high-precision measurements. A central issue we discuss here, is how to make optimal use of both the spatial and the quantum degrees of freedom of light for characterizing and manipulating arbitrary observable parameters in a linear scattering system into which suitably engineered light fields are injected. Here, we discuss a comprehensive framework based on a quantum operator that can be assembled solely from the scattering matrix of a system and its dependence on the corresponding local parameter, making this operator experimentally measurable from the far field using only classical light. From this, the effect of quantum light in the near field, i.e., in the vicinity of the target object, can be inferred. Based on this framework, it is straightforward to formulate optimal protocols on how to jointly design both the spatial shape and the quantum characteristics of light for micromanipulation as well as for parameter estimation in arbitrarily complex media. Also, the forces of the quantum vacuum naturally emerge from this formalism. The aim of our tutorial is to bring different perspectives into alignment and thereby build a bridge between the different communities of wave control, quantum optics, micromanipulation, quantum metrology, and vacuum physics.