bluuebunny/crossref_metadata_2025_split huggingface dataset:
β-Catenin activation synergizes with Pten loss and Myc overexpression in Notch-independent T-ALL
Authors: Kaveri Deepika , Kastner Philippe , Dembélé Doulaye , Nerlov Claus , Chan Susan , Kirstetter Peggy 
Published: June 2013

Key PointsWnt activation, Pten loss, and Myc translocation synergize to define a novel subset of murine Notch-independent T-ALL.
Downregulation of the activating NKp30 ligand B7-H6 by HDAC inhibitors impairs tumor cell recognition by NK cells
Authors: Fiegler Nathalie , Textor Sonja , Arnold Annette , Rölle Alexander , Oehme Ina , Breuhahn Kai , Moldenhauer Gerhard , Witzens-Harig Mathias , Cerwenka Adelheid 
Published: June 2013

Key PointsHDAC inhibitors downregulate expression of the activating NKp30 ligand B7-H6, reducing NKp30-dependent tumor cell recognition by NK cells. Our results have implications for the design of potential cancer treatments combining immunotherapy with HDAC inhibitors.
Dietary α-linolenic acid increases the platelet count in ApoE−/− mice by reducing clearance
Authors: Stivala Simona , Reiner Martin F. , Lohmann Christine , Lüscher Thomas F. , Matter Christian M. , Beer Juerg H. 
Published: June 2013

Key Points
Dietary ALA decreases platelet clearance in a mouse model of atherosclerosis. ALA reduces platelet activation and tumor necrosis factor-alpha–converting enzyme-dependent GPIb cleavage.
Mobilization of lipids and fortification of cell wall and cuticle are important in host defense against Hessian fly
Authors: Khajuria Chitvan , Wang Haiyan , Liu Xuming , Wheeler Shanda , Reese John C , El Bouhssini Mustapha , Whitworth R Jeff , Chen Ming-Shun 
Published: June 2013

AbstractBackgroundWheat – Hessian fly interaction follows a typical gene-for-gene model. Hessian fly larvae die in wheat plants carrying an effective resistance gene, or thrive in susceptible plants that carry no effective resistance gene.ResultsGene sets affected by Hessian fly attack in resistant plants were found to be very different from those in susceptible plants. Differential expression of gene sets was associated with differential accumulation of intermediates in defense pathways. Our results indicated that resources were rapidly mobilized in resistant plants for defense, including extensive membrane remodeling and release of lipids, sugar catabolism, and amino acid transport and degradation. These resources were likely rapidly converted into defense molecules such as oxylipins; toxic proteins including cysteine proteases, inhibitors of digestive enzymes, and lectins; phenolics; and cell wall components. However, toxicity alone does not cause immediate lethality to Hessian fly larvae. Toxic defenses might slow down Hessian fly development and therefore give plants more time for other types of defense to become effective.ConclusionOur gene expression and metabolic profiling results suggested that remodeling and fortification of cell wall and cuticle by increased deposition of phenolics and enhanced cross-linking were likely to be crucial for insect mortality by depriving Hessian fly larvae of nutrients from host cells. The identification of a large number of genes that were differentially expressed at different time points during compatible and incompatible interactions also provided a foundation for further research on the molecular pathways that lead to wheat resistance and susceptibility to Hessian fly infestation.
A compendium of molecules involved in vector-pathogen interactions pertaining to malaria
Authors: Sreenivasamurthy Sreelakshmi K , Dey Gourav , Ramu Manjula , Kumar Manish , Gupta Manoj K , Mohanty Ajeet K , Harsha HC , Sharma Pushkar , Kumar Nirbhay , Pandey Akhilesh , Kumar Ashwani , Prasad TS Keshava 
Published: June 2013

Abstract
Malaria is a vector-borne disease causing extensive morbidity, debility and mortality. Development of resistance to drugs among parasites and to conventional insecticides among vector-mosquitoes necessitates innovative measures to combat this disease. Identification of molecules involved in the maintenance of complex developmental cycles of the parasites within the vector and the host can provide attractive targets to intervene in the disease transmission. In the last decade, several efforts have been made in identifying such molecules involved in mosquito-parasite interactions and, subsequently, validating their role in the development of parasites within the vector. In this study, a list of mosquito proteins, which facilitate or inhibit the development of malaria parasites in the midgut, haemolymph and salivary glands of mosquitoes, is compiled. A total of 94 molecules have been reported and validated for their role in the development of malaria parasites inside the vector. This compendium of molecules will serve as a centralized resource to biomedical researchers investigating vector-pathogen interactions and malaria transmission.
Estimation of the effect of dalfampridine-ER on health utility by mapping the MSWS-12 to the EQ-5D in multiple sclerosis patients
Authors: Limone Brendan L , Sidovar Matthew F , Coleman Craig I 
Published: June 2013

Abstract

Background
Trials have not assessed the effect of dalfampridine-extended release (dalfampridine-ER) on health utility. We sought to evaluate the effect of dalfampridine-ER tablets (prolonged-release fampridine in Europe) on health utility in patients with multiple sclerosis (MS) by mapping subjects’ individual item scores from the 12-Item Multiple Sclerosis Walking Scale (MSWS-12) onto the Euroqol 5-Dimension (EQ-5D) health utility index.

Methods
Data from study MS-F203, a randomized trial of dalfampridine-ER tablets, 10 mg twice daily, in patients with MS, were used to calculate the health utility scores with two MSWS-12 to EQ-5D mapping equations (one derived in a North American [NA] registry, the other a United Kingdom [UK] registry). MS-F203 participants were categorized as dalfampridine-ER 20%-responders (achieving ≥20% improvement on the Timed 25-Foot Walk), dalfampridine-ER 20%-nonresponders (<20% improvement), or placebo patients. Mean change in health utility scores from baseline to each double-blind treatment evaluation (visits 3-6 occurring at post-randomization weeks 2, 6, 10, and 14) and each off-drug follow-up evaluation (visits 7-8 occurring at weeks 16 and 18) were calculated and reported as effect sizes (ESs).

Results
Using the NA-derived equation, dalfampridine-ER 20%-responders demonstrated improvement in health utility vs. placebo; starting at week 6 (mean difference in ES = 0.44, p = 0.002) and maintained at weeks 10 (ES = 0.41, p = 0.01) and 14 (ES = 0.71, p < 0.001). These improvements were no longer evident after dalfampridine-ER was discontinued (p > 0.05 at weeks 16 and 18). Dalfampridine-ER 20%-nonresponders did not show improvement vs. placebo at any visit (p > 0.05 for all). When using the UK-derived equation, improvement was seen in dalfampridine-ER 20%-responders vs. placebo at weeks 2, 6, 10, and 14 (ESs = 0.49, 0.55, 0.59, and 0.99; p < 0.03 for all), but not when dalfampridine-ER was discontinued (weeks 16 and 18; p > 0.05 for both). Dalfampridine-ER 20%-nonresponders showed no improvement at any visit (p > 0.05 for all).

Conclusion
Regardless of the equation used, dalfampridine-ER response was associated with an improvement in health utility.
Obstetric complications in women with polycystic ovary syndrome: a systematic review and meta-analysis
Authors: Qin Jun Z , Pang Li H , Li Mu J , Fan Xiao J , Huang Ru D , Chen Hong Y 
Published: June 2013

AbstractBackgroundPolycystic ovary syndrome (PCOS) is a common endocrine disorder in women of childbearing age. The risk of pregnancy and neonatal complications in women with PCOS is debatable. In order to determine the risk of pregnancy and neonatal complications, evidence regarding these risks was examined.MethodsLiterature searches were performed in the electronic databases MEDLINE, EMBASE, and CENTRAL based on the established strategy and eligible tries were included according to inclusion and exclusion criteria. A systematic literature review looking at rates of gestational diabetes mellitus (GDM), pregnancy-induced hypertension (PIH), preeclampsia, premature delivery, neonatal birth weight, caesarean section and admission to a neonatal intensive care unit (NICU) was conducted in women with PCOS. Pregnancy outcomes between women with PCOS versus controls were included. Sensitivity analyses were performed to determine the reliability of the available evidence and to validate the results. The study was performed with the approval of the ethics committee of the First Affiliated Hospital of Guangxi Medical University.ResultsA total of 27studies, involving 4982 women with PCOS and 119692 controls were eligible for the meta-analysis. Women with PCOS demonstrated a significantly higher risk of developing GDM (OR3.43; 95% CI: 2.49–4.74), PIH (OR3.43; 95% CI: 2.49–4.74), preeclampsia (OR2.17; 95% CI: 1.91–2.46), preterm birth (OR1.93; 95%CI: 1.45–2.57), caesarean section (OR 1.74; 95% CI: 1.38–2.11) compared to controls. Their babies had a marginally significant lower birth weight (WMD −0.11g; 95%CI: -0.19 – -0.03), and higher risk of admission to NICU (OR 2.32; 95% CI: 1.40–3.85) compared to controls.ConclusionsWomen with PCOS have increased risk of adverse pregnancy and neonatal complications. It is necessary to establish guidelines for supervision during pregnancy and parturition to prevent these complications.
Photonics based on carbon nanotubes
Authors: Gu Qingyuan , Gicquel-Guézo Maud , Loualiche Slimane , Pouliquen Julie Le , Batte Thomas , Folliot Hervé , Dehaese Olivier , Grillot Frederic , Battie Yann , Loiseau Annick , Liang Baolai , Huffaker Diana 
Published: June 2013

Abstract
Among direct-bandgap semiconducting nanomaterials, single-walled carbon nanotubes (SWCNT) exhibit strong quasi-one-dimensional excitonic optical properties, which confer them a great potential for their integration in future photonics devices as an alternative solution to conventional inorganic semiconductors. In this paper, we will highlight SWCNT optical properties for passive as well as active applications in future optical networking. For passive applications, we directly compare the efficiency and power consumption of saturable absorbers (SAs) based on SWCNT with SA based on conventional multiple quantum wells. For active applications, exceptional photoluminescence properties of SWCNT, such as excellent light-emission stabilities with temperature and excitation power, hold these nanometer-scale materials as prime candidates for future active photonics devices with superior performances.
Systems of singular differential equations with pulse action
Authors: Boichuk Alexandr , Langerová Martina , Růžičková Miroslava , Voitushenko Evgenij 
Published: June 2013

Abstract
The paper deals with the singular systems of ordinary differential equations with impulsive action under the assumption that the considered systems can be reduced into the central canonical form. An approach which combines the theory of impulsive differential equations and known results from the theory of singular Fredholm boundary value problems is used. Necessary and sufficient conditions for the existence of solutions of the singular boundary value problems with impulsive action are derived. Moreover, an algorithm for the construction of the family of linearly independent solutions is shown.

MSC:34A09, 34A37.
New insights into mechanisms behind miscarriage
Authors: Larsen Elisabeth Clare , Christiansen Ole Bjarne , Kolte Astrid Marie , Macklon Nick 
Published: June 2013

AbstractSporadic miscarriage is the most common complication of early pregnancy. Two or three consecutive pregnancy losses is a less common phenomenon, and this is considered a distinct disease entity. Sporadic miscarriages are considered to primarily represent failure of abnormal embryos to progress to viability. Recurrent miscarriage is thought to have multiple etiologies, including parental chromosomal anomalies, maternal thrombophilic disorders, immune dysfunction and various endocrine disturbances. However, none of these conditions is specific to recurrent miscarriage or always associated with repeated early pregnancy loss. In recent years, new theories about the mechanisms behind sporadic and recurrent miscarriage have emerged. Epidemiological and genetic studies suggest a multifactorial background where immunological dysregulation in pregnancy may play a role, as well as lifestyle factors and changes in sperm DNA integrity. Recent experimental evidence has led to the concept that the decidualized endometrium acts as biosensor of embryo quality, which if disrupted, may lead to implantation of embryos destined to miscarry. These new insights into the mechanisms behind miscarriage offer the prospect of novel effective interventions that may prevent this distressing condition.
Retrospective genomic analysis of sorghum adaptation to temperate-zone grain production
Authors: Thurber Carrie S , Ma Justin M , Higgins Race H , Brown Patrick J 
Published: June 2013

Abstract
Background
Sorghum is a tropical C4 cereal that recently adapted to temperate latitudes and mechanized grain harvest through selection for dwarfism and photoperiod-insensitivity. Quantitative trait loci for these traits have been introgressed from a dwarf temperate donor into hundreds of diverse sorghum landraces to yield the Sorghum Conversion lines. Here, we report the first comprehensive genomic analysis of the molecular changes underlying this adaptation.

Results
We apply genotyping-by-sequencing to 1,160 Sorghum Conversion lines and their exotic progenitors, and map donor introgressions in each Sorghum Conversion line. Many Sorghum Conversion lines carry unexpected haplotypes not found in either presumed parent. Genome-wide mapping of introgression frequencies reveals three genomic regions necessary for temperate adaptation across all Sorghum Conversion lines, containing the Dw1, Dw2, and Dw3 loci on chromosomes 9, 6, and 7 respectively. Association mapping of plant height and flowering time in Sorghum Conversion lines detects significant associations in the Dw1 but not the Dw2 or Dw3 regions. Subpopulation-specific introgression mapping suggests that chromosome 6 contains at least four loci required for temperate adaptation in different sorghum genetic backgrounds. The Dw1 region fractionates into separate quantitative trait loci for plant height and flowering time.

Conclusions
Generating Sorghum Conversion lines has been accompanied by substantial unintended gene flow. Sorghum adaptation to temperate-zone grain production involves a small number of genomic regions, each containing multiple linked loci for plant height and flowering time. Further characterization of these loci will accelerate the adaptation of sorghum and related grasses to new production systems for food and fuel.
Functional cooperation of spns2 and fibronectin in cardiac and lower jaw development
Authors: Hisano Yu , Ota Satoshi , Takada Shinji , Kawahara Atsuo 
Published: June 2013

Summary
The lipid mediator sphingosine-1-phosphate (S1P) is a regulator of cardiac development in zebrafish, as disruption of its receptor s1pr2 or transporter spns2 causes migration defects in cardiac progenitors. To examine the genetic interaction of S1P signaling and the cell adhesion molecule fibronectin, we have established a fn;spns2 double mutant. Cardiac migration defects in fn;spns2 mutants were more severe than those in fn or spns2 mutants. We further found that the lower jaw morphology was disorganized in the fn;spns2 mutant, while it had a slightly shortened anterior–posterior distance in the ventral pharyngeal arch in fn and spns2 mutants relative to wild type. Knockdown of fn in the s1pr2 mutant, but not in the s1pr1 mutant, resulted in severe defects in cardiac migration and ventral pharyngeal arch arrangement. Further, in the background of the fn mutant, knockdown of endothelin receptor A (ednra), which was downregulated in the spns2 mutant, caused pharyngeal defects resembling those in the fn;spns2 mutant. These results strongly suggest that Spns2-S1PR2 signaling and fibronectin cooperatively regulate both cardiac and lower jaw development in zebrafish.
Changes in media, changes in the profession? The shifts of the journalistic field as a challenge for young Austrian journalists
Authors: Kirchhoff Susanne , Prandner Dimitri , Hummel Roman 
Published: June 2013

Abstract
Based on Pierre Bourdieu’s theory of the social field, the following article examines how changes in the journalistic field are related to self-perceptions and career strategies of individuals working in Austrian news media. In making use of Bourdieu’s theory, survey-based information regarding role models and self-perception can be interpreted within its proper context and thus be made accessible to educational and other institutions in a practice-oriented manner. Data from three interrelated studies show that journalists in Austria see their job as a creative profession with little need for formal education, and insist on the importance of personal networks. Despite this, the younger and female journalists are more likely to educate themselves in hopes of finding a permanent job in a crowded profession that offers little job stability.
Still something special?: A comparative study of public service journalists’ values in Spain and Sweden
Authors: Ibarra Karen Arriaza , Nord Lars W. 
Published: June 2013

Abstract
While most studies of public service media changes in European media systems focus on regulatory policies and audience markets, this article investigates the development of professional journalistic values and newsroom practices among public service journalists. Previous studies have indicated that news values among public service journalists to a large extent have been guided by the principles of public interest and social significance. However, the majority of these studies were conducted mainly in the broadcast era, where competition was less important than it is today. In this article, the objective is to analyse public service journalists’ professional values and newsroom practices in a digital age. The study is based on a comparison between Spanish and Swedish journalists working within the public service media in the two countries, but within strongly diverging public service media conditions. The article compares professional values among public service journalists in the two countries, as well as between journalists working in the public and the private media sector in each country. Methodologically, the comparison is based on nation surveys among Spanish and Swedish journalists conducted during 2010. The results show similar perceptions of news values and between public and private journalists in both countries, but public journalists are more concerned about decreasing quality of journalism and increasing commercialization.
Press freedom in the United Kingdom and the Leveson debate
Authors: Elstein David 
Published: June 2013

Abstract
The repercussions of the phone-hacking scandal at the now-defunct News of the World are reshaping the regulation, culture, practice and ethics of the press in the United Kingdom. Though a purely British case, the impact on the future of newspapers and the media will not be confined to the British Isles. The scandal and the subsequent public enquiry led by Lord Justice Leveson will provide fertile ground for media and journalism scholars to focus their research and investigations. Leveson’s recommendations on the future of press regulation are certain to rework the current system in the United Kingdom, where the press has traditionally been self-regulated voluntarily through Press Complaints Commission. In this article, David Elstein, chairman of open Democracy, looks into the phone-hacking scandal, examining its various facets and what its impact will be on the future of press freedom and media ownership in Britain.
Where to place inaccessible subjects in Dutch: The role of definiteness and animacy
Authors: Vogels Jorrig , Van Bergen Geertje 
Published: June 2013

AbstractCross-linguistically, both subjects and topical information tend to be placed at the beginning of a sentence. Subjects are generally highly topical, causing both tendencies to converge on the same word order. However, subjects that lack prototypical topic properties may give rise to an incongruence between the preference to start a sentence with the subject and the preference to start a sentence with the most accessible information. We present a corpus study in which we investigate in what syntactic position (preverbal or postverbal) such low-accessible subjects are typically found in Dutch natural language. We examine the effects of both discourse accessibility (definiteness) and inherent accessibility (animacy). Our results show that definiteness and animacy interact in determining subject position in Dutch. Non-referential (bare) subjects are less likely to occur in preverbal position than definite subjects, and this tendency is reinforced when the subject is inanimate. This suggests that these two properties that make the subject less accessible together can ‘gang up’ against the subject first preference. The results support a probabilistic multifactorial account of syntactic variation.
In situ Preparation of Gold Nanoparticles in Alginate Gel Matrix by Solution Plasma Sputtering Process
Authors: Watthanaphanit Anyarat , Panomsuwan Gasidit , Saito Nagahiro 
Published: June 2013

ABSTRACTThe rapid synthesis of gold nanoparticles (AuNPs) was done by solution plasma sputtering (SPS) process in the presence of a biopolymer, sodium alginate. We utilized the alginate polymer in order to meet three important requirements: (1) to promote the generation of plasma in liquid environment, (2) to provide colloidal stability, and (3) to render biocompatibility to the AuNPs. The effect of sodium alginate concentration (varied as 0.2, 0.5, and 0.9 %w/v) and plasma sputtering time on the particle size and the physical absorption property of the AuNPs were studied. The results indicated that preparation of AuNPs in alginate gel matrix was successful by the SPS process in one step without any reducing agents. This technique has high potential as a novel strategy to produce AuNPs suspended in alginate aqueous solution which is suitable for biomedical application.