bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Directing Group Assisted Nucleophilic Substitution of Propargylic Alcohols via o‐Quinone Methide Intermediates: Broensted Acid Catalyzed, Highly Enantio‐ and Diastereoselective Synthesis of 7‐Alkynyl‐12a‐acetamido‐Substituted Benzoxanthenes.
Authors: Saha Satyajit , Schneider Christoph 
Published: June 2015

AbstractThe title reaction is catalyzed by a BINOL‐based, chiral phosphoric acid.
ChemInform Abstract: Broensted Acid‐Catalyzed, Highly Enantioselective Addition of Enamides to in situ‐Generated ortho‐Quinone Methides: A Domino Approach to Complex Acetamidotetrahydroxanthenes.
Authors: Saha Satyajit , Schneider Christoph 
Published: June 2015

AbstractA chiral BINOL‐based phosphoric acid catalyst is found to control efficiently the enantioselectivity of the C—C bond forming process.
ChemInform Abstract: Highly Regio‐ and Enantioselective Synthesis of N‐Substituted 2‐Pyridones: Iridium‐Catalyzed Intermolecular Asymmetric Allylic Amination.
Authors: Zhang Xiao , Yang Ze‐Peng , Huang Lin , You Shu‐Li 
Published: June 2015

AbstractThe Ir‐catalyzed asymmetric allylic amination of 2‐hydroxypyridines with allyl methyl carbonates (II) is reported for the first time.
ChemInform Abstract: Cu‐Catalyzed Concise Synthesis of Pyridines and 2‐(1H)‐Pyridones from Acetaldehydes and Simple Nitrogen Donors.
Authors: Li Ziyuan , Huang Xiaoqiang , Chen Feng , Zhang Chun , Wang Xiaoyang , Jiao Ning 
Published: June 2015

Abstract3,5‐Diarylpyridines, 3,5‐diaryl‐2‐ketopyridines and 3,5‐(het)aryl‐2‐(1H)‐pyridones are prepared using ammonium ceric nitrate, trimethylsilyl azide or 2‐aminopyridine as efficient nitrogen donors, respectively.
ChemInform Abstract: Palladium‐Catalyzed [4 + 2] Cycloaddition of Aldimines and 1,4‐Dipolar Equivalents via Amphiphilic Allylation.
Authors: Hirata Goki , Yamada Naoshi , Sanada Shohei , Onodera Gen , Kimura Masanari 
Published: June 2015

AbstractThe title reaction is promoted by diethylzinc.
ChemInform Abstract: Metal‐Free Ring Expansion of Indoles with Nitroalkenes: A Simple, Modular Approach to 3‐Substituted 2‐Quinolones.
Authors: Aksenov Alexander V. , Smirnov Alexander N. , Aksenov Nicolai A. , Aksenova Inna V. , Matheny Jonathon P. , Rubin Michael 
Published: June 2015

AbstractThe title compounds are obtained by a novel acid‐mediated cascade transformation via the ANRORC (addition of nucleophile, ring opening, and ring closure) mechanism.
ChemInform Abstract: Highly Selective Synthesis of Functionalized Polyhydroisoquinoline Derivatives via a Three‐Component Domino Reaction.
Authors: Feng Xian , Wang Jian‐Jun , Xun Zhan , Zhang Juan‐Juan , Huang Zhi‐Bin , Shi Da‐Qing 
Published: June 2015

AbstractA convenient microwave promoted three‐component domino reaction of β‐ketoamides (I), pentandial (II), and malononitrile (III) is developed to give deca‐ and octahydroisoquinolines (IV) and (VI).
ChemInform Abstract: Intramolecular Cycloadditions of Photogenerated Azaxylylenes with Oxadiazoles Provide Direct Access to Versatile Polyheterocyclic Ketopiperazines Containing a Spiro‐Oxirane Moiety.
Authors: Kumar N. N. Bhuvan , Kuznetsov Dmitry M. , Kutateladze Andrei G. 
Published: June 2015

AbstractThe photogenerated diketopiperazinoquinolinol products (II) contain a reactive oxirane moiety which proves synthetically useful for further transformations.
ChemInform Abstract: Synthesis of 4,6‐Unsubstituted 2‐Aminodihydropyrimidine‐5‐carboxylates Through Sequential Staudinger/Aza‐Wittig/Cyclization Reactions.
Authors: Nishimura Yoshio , Cho Hidetsura 
Published: June 2015

AbstractThe one‐pot synthesis of the title compounds (III) proceeds in high overall yield.
ChemInform Abstract: Efficient Synthesis of 2‐Methylenethiazolo[2,3‐b]quinazolinone Derivatives.
Authors: Mahdavi Mohammad , Bialam Maryam , Saeedi Mina , Jafarpour Farnaz , Foroumadi Alireza , Shafiee Abbas 
Published: June 2015

Abstractby KOH‐reaction of substituted o‐amino‐N‐(prop‐2‐yn‐1‐yl) aromatic amides (I) with CS2
ChemInform Abstract: Integrated One‐Flow Synthesis of Heterocyclic Thioquinazolinones Through Serial Microreactions with Two Organolithium Intermediates.
Authors: Kim Heejin , Lee Hyune‐Jea , Kim Dong‐Pyo 
Published: June 2015

AbstractA three‐step reaction consisting of bromine‐lithium exchange at the isothiocyanate (I), reaction of the resulting aryllithium reagent with arylisocyanates, and a final S‐benzylation with benzyl bromides is carried out in a continuous‐flow integrated microfluidic reactor to give thioquinazolines (IV).
ChemInform Abstract: Iodine‐Mediated Synthesis of Indazolo‐Quinazolinones via a Multi‐Component Reaction.
Authors: Palaniraja Jeyakannu , Roopan Selvaraj Mohana 
Published: June 2015

AbstractAn efficient and simple method for the synthesis of indazolo‐quinazolinone fused ring systems by multi‐component reaction involving an in situ generation of the 1H‐indazol‐3‐amine derivative in ethanol followed by its reaction with diketone and various arylaldehydes in acetonitrile is developed.
ChemInform Abstract: Potassium Iodide‐Catalyzed Three‐Component Synthesis of 2‐Arylquinazolines via Amination of Benzylic C—H Bonds of Methylarenes.
Authors: Zhao Dan , Shen Qi , Li Jian‐Xin 
Published: June 2015

AbstractCommonly used ammonia salt and the sp3 carbon in methylarenes are utilized as nitrogen and C1 sources to establish a novel potassium iodide‐catalyzed three‐component synthesis of quinazolines in which an aryl aldehyde is involved as a key intermediate.
ChemInform Abstract: Chiral Phosphoric Acid Catalyzed Highly Enantioselective Friedel—Crafts Alkylation Reaction of C3‐Substituted Indoles to β,γ‐Unsaturated α‐Ketimino Esters.
Authors: Bi Bo , Lou Qin‐Xin , Ding Yu‐Yang , Chen Sheng‐Wei , Zhang Sha‐Sha , Hu Wen‐Hui , Zhao Jun‐Ling 
Published: June 2015

AbstractThe scalable reaction allows the preparation of C2‐substituted indole derivatives bearing an α‐ketimino ester motif in moderate to high yields.
ChemInform Abstract: Synthesis of Enaminones and Their Difluoroboron Complexes Through Domino Aryl Migration.
Authors: Yang Zheng , Jiang Bo , Hao Wen‐Juan , Zhou Peng , Tu Shu‐Jiang , Li Guigen 
Published: June 2015

AbstractThis new domino strategy allows the selective synthesis of boron complexes.
ChemInform Abstract: endo‐Selective Pd‐Catalyzed Silyl Methyl Heck Reaction.
Authors: Parasram Marvin , Iaroshenko Viktor O. , Gevorgyan Vladimir 
Published: June 2015

AbstractIodomethylsilyl ethers of phenols and aliphatic alkenols react to allylic silyloxycycles via Heck‐reaction.
ChemInform Abstract: Nickel‐Catalyzed Alkynylation of Anisoles via C—O Bond Cleavage.
Authors: Tobisu Mamoru , Takahira Tsuyoshi , Ohtsuki Akimichi , Chatani Naoto 
Published: June 2015

AbstractThis novel cross‐coupling reaction allows the alkynylation of anisole and related ethers with Grignard reagent (II).
ChemInform Abstract: Chemistry of Phosphorus Ylides. Part 37. The Reaction of Phosphonium Ylides with Indoles and Naphthofurans. Synthesis of Phosphanylidenes, Pyrans, Cyclobutenes, and Pyridazine as Antitumor Agents.
Authors: Maigali Soher S. , El‐Hussieny Marwa , Soliman Fouad M. 
Published: June 2015

AbstractAn interesting approach to the synthesis of a variety of new cyclic and heterocyclic phosphorus compounds via direct reaction of readily available indolinones (III) or related naphthofuranone derivatives (IX) with phosphacumulenes (IV) or phosphallene ylide (VI) is given.
ChemInform Abstract: Synthesis of Annelated Phospholes Through Intramolecular C—H Activation by Monovalent Phosphorus.
Authors: Wei Xinda , Lu Zongming , Zhao Xu , Duan Zheng , Mathey Francois 
Published: June 2015

AbstractA variety of phosphole W(CO)5‐complexes is synthesized by thermolysis of the corresponding 7‐phosphanorbornadiene complexes.
ChemInform Abstract: Copper Nanoparticles Catalyzed Se(Te)—Se(Te) Bond Activation: A Straightforward Route Towards Unsymmetrical Organochalcogenides from Boronic Acids.
Authors: Mohan Balaji , Yoon Chohye , Jang Seongwan , Park Kang Hyun 
Published: June 2015

AbstractCopper nanoparticles immobilized on activated charcoal are prepared and successfully employed as catalyst for the cross‐coupling of diselenides or ditellurides with boronic acids (II) and esters (IV).
ChemInform Abstract: Abietane Diterpenoids from Perovskia atriplicifolia and Their anti‐HBV Activities.
Authors: Jiang Zhi‐Yong , Li Zhong‐Qiu , Huang Chao‐Guan , Zhou Jun , Hu Qiu‐Fen , Liu Wen‐Xing , Huang Xiang‐Zhong , Wang Wei , Zhang Li‐Zhu , Xia Fu‐Ting 
Published: June 2015

AbstractThree new compounds, atriplicone A (I), B (II), and C (III) are isolated together with five known compounds.
ChemInform Abstract: Palladium‐Catalyzed Stereoselective C‐Glycosylation of Glycals with Sodium Arylsulfinates.
Authors: Ma Jimei , Xiang Shaohua , Jiang Hong , Liu Xue‐Wei 
Published: June 2015

AbstractC‐aryl glycosides are formed by palladium‐catalyzed carbon‐Ferrier‐type coupling with high regio‐ and stereoselectivity.
ChemInform Abstract: Chemistry of Pent‐4‐yne‐1,3‐diones (Acetylenic β‐Diketones) as Precursors for Heterocyclic Compounds
Authors: Atta Kamal F. M. , Farahat Omaima O. M. , Al‐Shargabi Tareq Q. , Marei Mohamed G. , El Ashry El Sayed H. 
Published: June 2015

AbstractReview: 76 refs.
ChemInform Abstract: Novel Strategies for Catalytic Asymmetric Synthesis of C1‐Chiral 1,2,3,4‐Tetrahydroisoquinolines and 3,4‐Dihydroisoquinolines
Authors: Liu Wangsheng , Liu Shasha , Jin Ruiwen , Guo Hao , Zhao Jinbo 
Published: June 2015

AbstractReview: 75 refs.
ChemInform Abstract: Alumina Sulfuric Acid (ASA), Tungstate Sulfuric Acid (TSA), Molybdate Sulfuric Acid (MSA) and Xanthan Sulfuric Acid (XSA) as Solid and Heterogeneous Catalysts in Green Organic Synthesis: A Review
Authors: Vekariya Rajesh H. , Patel Hitesh D. 
Published: June 2015

AbstractReview: 63 refs.
ChemInform Abstract: Emerging Energy and Environmental Applications of Vertically‐Oriented Graphenes
Authors: Bo Zheng , Mao Shun , Jun Han Zhao , Cen Kefa , Chen Junhong , Ostrikov Kostya (Ken) 
Published: June 2015

AbstractReview: tutorial review on plasma synthesis of vertically‐oriented graphenes, growth mechanism, and properties for energy and environmental applications; 50 refs.
Second‐line chemotherapy for advanced biliary tract cancer after failure of the gemcitabine‐platinum combination: A large multicenter study by the Association des Gastro‐Entérologues Oncologues
Authors: Brieau Bertrand , Dahan Laetitia , De Rycke Yann , Boussaha Tarek , Vasseur Philippe , Tougeron David , Lecomte Thierry , Coriat Romain , Bachet Jean‐Baptiste , Claudez Pierre , Zaanan Aziz , Soibinet Pauline , Desrame Jérome , Thirot‐Bidault Anne , Trouilloud Isabelle , Mary Florence , Marthey Lysiane , Taieb Julien , Cacheux Wulfran , Lièvre Astrid 
Published: June 2015

BACKGROUNDFew data are available on second‐line chemotherapy (CT2) for advanced biliary tract cancer (ABTC). The aim of this multicenter study was to describe the CT2 regimens used, the response rates, and the outcomes of patients treated with various CT2 regimens.METHODSPatients who received CT2 for ABTC at 17 French institutions after the failure of the gemcitabine‐platinum combination were retrospectively studied. Progression‐free survival (PFS) and overall survival (OS) were estimated with the Kaplan‐Meier method. Cox models were used for multivariate analyses.RESULTSAmong 603 patients who received first‐line chemotherapy (CT1) for ABTC, 196 received CT2: 5‐fluorouracil (5‐FU) and irinotecan (n = 64), 5‐FU and oxaliplatin (n = 21), 5‐FU and cisplatin (n = 38), 5‐FU or capecitabine (n = 40), sunitinib (n = 10), or other various regimens (n = 23). Among the 186 assessable patients, there were 22 partial responses and 70 stabilizations. After a median follow‐up of 26.4 months, the median PFS and OS were 3.2 and 6.7 months, respectively. There was no significant difference in PFS or OS between CT2 regimens. Fluoropyrimidine‐based doublet chemotherapy was not superior to fluoropyrimidine alone in terms of OS and PFS. In a multivariate analysis, a performance status of 0 to 1, disease control with CT1, and a carbohydrate antigen 19‐9 (CA 19‐9) level ≤ 400 IU/mL were significantly associated with longer PFS and OS. Grade 3 to 4 toxicity occurred in 32% of the patients.CONCLUSIONSCT2 might provide disease control for selected patients with ABTC after the failure of gemcitabine‐platinum, but the prognosis remains poor. No particular regimen seems superior to others, and this calls for new treatments. A good performance status, disease control with CT1, and a low level of CA 19‐9 were associated with longer survival. Cancer 2015;121:3290–3297. © 2015 American Cancer Society.
Channel‐aware repetitive data collection in wireless sensor networks
Authors: Kim Ryangsoo , Choi Jinho , Lim Hyuk 
Published: June 2015

SummaryWireless sensor networking technology has been applied in practice to a variety of information‐gathering infrastructures, where sensing data are repetitively delivered to a data collector within a session period. For efficient energy conservation, each sensor node can wait for a higher channel gain before it begins the transmission of sensing data and transmits them with a power that is inversely proportional to the channel gain. However, if the node waits for higher channel gain, switching to the sleeping mode takes a longer time. We formulate this channel‐aware data transmission problem using an optimization problem with linear constraints. The numerical simulations indicate that the proposed method significantly reduces the energy consumption compared with other heuristic methods. Copyright © 2015 John Wiley & Sons, Ltd.
The evolution of obligate sex: the roles of sexual selection and recombination
Authors: Kleiman Maya , Hadany Lilach 
Published: June 2015

AbstractThe evolution of sex is one of the greatest mysteries in evolutionary biology. An even greater mystery is the evolution of obligate sex, particularly when competing with facultative sex and not with complete asexuality. Here, we develop a stochastic simulation of an obligate allele invading a facultative population, where males are subject to sexual selection. We identify a range of parameters where sexual selection can contribute to the evolution of obligate sex: Especially when the cost of sex is low, mutation rate is high, and the facultative individuals do not reproduce sexually very often. The advantage of obligate sex becomes larger in the absence of recombination. Surprisingly, obligate sex can take over even when the population has a lower mean fitness as a result. We show that this is due to the high success of obligate males that can compensate the cost of sex.
Effects of theEpichloëfungal endophyte symbiosis withSchedonorus pratensison host grass invasiveness
Authors: Shukla Kruti , Hager Heather A. , Yurkonis Kathryn A. , Newman Jonathan A. 
Published: June 2015

AbstractInitial studies of grass–endophyte mutualisms usingSchedonorus arundinaceuscultivar Kentucky‐31 infected with the vertically transmitted endophyteEpichloë coenophialafound strong, positive endophyte effects on host‐grass invasion success. However, more recent work using different cultivars ofS. arundinaceushas cast doubt on the ubiquity of this effect, at least as it pertains toS. arundinaceus–E. coenophiala. We investigated the generality of previous work on vertically transmittedEpichloë‐associated grass invasiveness by studying a pair of very closely related species:S. pratensisandE. uncinata. Seven cultivars ofS. pratensisand two cultivars ofS. arundinaceusthat were developed with high‐ or low‐endophyte infection rate were broadcast seeded into 2 × 2‐m plots in a tilled, old‐field grassland community in a completely randomized block design.Schedonorusabundance, endophyte infection rate, and co‐occurring vegetation were sampled 3, 4, 5, and 6 years after establishment, and the aboveground invertebrate community was sampled inS. pratensisplots 3 and 4 years after establishment. Endophyte infection did not enable the host grass to achieve high abundance in the plant community. Contrary to expectations, high‐endophyteS. pratensisincreased plant richness relative to low‐endophyte cultivars. However, as expected, high‐endophyteS. pratensismarginally decreased invertebrate taxon richness. Endophyte effects on vegetation and invertebrate community composition were inconsistent among cultivars and were weaker than temporal effects. The effect of the grass–Epichloësymbiosis on diversity is not generalizable, but rather specific to species, cultivar, infection, and potentially site. Examining grass–endophyte systems using multiple cultivars and species replicated among sites will be important to determine the range of conditions in which endophyte associations benefit host grass performance and have subsequent effects on co‐occurring biotic communities.
Asymmetric Dearomatization of 1‐Amino­naphthalene Derivatives through C–C Bond Formation with Electron‐Rich Heterocycles as Nucleophiles
Authors: Baba Takafumi , Oka Junko , Noguchi Keiichi , Tanaka Ken 
Published: June 2015

AbstractA cationic gold(I)/axially chiral biaryl bis(phosphine) complex has been employed to catalyze the asymmetric dearomatization reactions of 1‐aminonaphthalene derivatives through a C–C bond‐forming reaction with electron‐rich heterocycles as the nucleophiles. These reactions afford pentacyclic heterocycles in good yields with moderate enantiomeric excess (ee) values.
Automatic whole brain tract‐based analysis using predefined tracts in a diffusion spectrum imaging template and an accurate registration strategy
Authors: Chen Yu‐Jen , Lo Yu‐Chun , Hsu Yung‐Chin , Fan Chun‐Chieh , Hwang Tzung‐Jeng , Liu Chih‐Min , Chien Yi‐Ling , Hsieh Ming H. , Liu Chen‐Chung , Hwu Hai‐Gwo , Tseng Wen‐Yih Isaac 
Published: June 2015

AbstractAutomated tract‐based analysis of diffusion MRI is an important tool for investigating tract integrity of the cerebral white matter. Current template‐based automatic analyses still lack a comprehensive list of tract atlas and an accurate registration method. In this study, tract‐based automatic analysis (TBAA) was developed to meet the demands. Seventy‐six major white matter tracts were reconstructed on a high‐quality diffusion spectrum imaging (DSI) template, and an advanced two‐step registration strategy was proposed by incorporating anatomical information of the gray matter from T1‐weighted images in addition to microstructural information of the white matter from diffusion‐weighted images. The automatic analysis was achieved by establishing a transformation between the DSI template and DSI dataset of the subject derived from the registration strategy. The tract coordinates in the template were transformed to native space in the individual's DSI dataset, and the microstructural properties of major tract bundles were sampled stepwise along the tract coordinates of the subject's DSI dataset. In a validation study of eight well‐known tracts, our results showed that TBAA had high geometric agreement with manual tracts in both deep and superficial parts but significantly smaller measurement variability than manual method in functional difference. Additionally, the feasibility of the method was demonstrated by showing tracts with altered microstructural properties in patients with schizophrenia. Fifteen major tract bundles were found to have significant differences after controlling the family‐wise error rate. In conclusion, the proposed TBAA method is potentially useful in brain‐wise investigations of white matter tracts, particularly for a large cohort study. Hum Brain Mapp 36:3441–3458, 2015. © 2015 Wiley Periodicals, Inc.
Serum albumin level at diagnosis of diffuse large B‐cell lymphoma: an important simple prognostic factor
Authors: Bairey Osnat , Shacham‐Abulafia Adi , Shpilberg Ofer , Gurion Ronit 
Published: June 2015

AbstractThis study compared the value of several simple laboratory parameters with known prognostic models for predicting survival in patients with diffuse large B‐cell lymphoma (DLBCL). The data of 157 adult patients with DLBCL diagnosed at Rabin Medical Center in 2004–2008 and treated with R‐CHOP immunochemotherapy were retrospectively reviewed. Main clinical features of the cohort were as follows: mean age 63.0 years, 43% male, 63% stage III/IV disease, 28% ECOG performance status >2, 60% elevated lactate dehydrogenase level. Median duration of follow‐up was 6.6 years. The NCCN‐International Prognostic Index (IPI) was found to be a more powerful prognosticator than the IPI. Five‐year overall survival (OS) was 69.6; 73.6% for patients with intermediate NCCN‐IPI and 38.4% for patients with poor NCCN‐IPI. On univariate analysis, pretreatment hemoglobin and albumin levels were significantly associated with survival. By albumin level, 5‐year OS was 77.6 + 4% in patients with >3.5 g/dl and 53 + 7% in patients with <3.5 g/dl (p < 0.001); 5‐year progression‐free survival (PFS) was 69.9% and 50.9%, respectively (p = 0.002). By hemoglobin level, 5‐year OS was 82.9 + 4.5% in patients with >12 g/dl and 58.8 + 5% in patients with <12 g/dl (p = 0.007); 5‐year PFS was 75.5% and 54.1%, respectively (p = 0.008). On multivariate analysis with Cox regression, pretreatment albumin level was a significant independent predictor of OS. Furthermore, 5‐year OS of patients with a high NCCN‐IPI and albumin < 3.5 g/dl was 29.2% compared with 60% in patients with albumin > 3.5 g/dl (p = 0.022). In conclusion, pretreatment albumin level is a strong prognostic factor for OS in patients with DLBCL and can discriminate high‐risk patients for good and poor prognosis. Copyright © 2015 John Wiley & Sons, Ltd.
Candidate gene association studies and risk of Hodgkin lymphoma: a systematic review and meta‐analysis
Authors: Sud Amit , Hemminki Kari , Houlston Richard S. 
Published: June 2015

AbstractTo evaluate the contribution of association studies of candidate polymorphisms to inherited predisposition to Hodgkin lymphoma (HL), we conducted a systematic review and meta‐analysis of published case‐control studies. Of the variants examined more than once in candidate gene association studies, we identified 21 studies that reported on 12 polymorphic variants in 10 genes. Data were also extracted from a published genome wide association study to allow analysis of an additional 47 variants in a further 30 genes. Promising associations were seen in nine of the variants (p < 0.05). Given that the estimated false positive report probabilities (FPRPs) for all associations are high (i.e. FPRP > 0.2), these findings should be interpreted with caution. While studies of candidate polymorphisms may be an attractive means of identifying risk factors for HL, future studies should employ sample sizes adequately powered to identify variants having only modest effects on HL risk. Furthermore, because of aetiological heterogeneity within HL, stratification of genotyping according to age, tumour Epstein‐Barr virus status and histology is essential. Copyright © 2015 John Wiley & Sons, Ltd.