bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does the size of the neuroendocrine-carcinoma component determine the prognosis of gallbladder cancer?
Authors: Hu Ya-Fei , Wang Jun-Ke , Ma Wen-Jie , Hu Hai-Jie , Gu Han-Fei , Liu Fei , Lv Tian-Run , Yang Si-Qi , Dai Yu-Shi , Zou Rui-Qi , Jin Yan-Wen , Li Fu-Yu 
Published: July 2024

BackgroundGallbladder mixed neuroendocrine-non-neuroendocrine neoplasm generally consists of a gallbladder neuroendocrine tumor and a non-neuroendocrine component. The World Health Organization (WHO) in 2019 established a guideline requiring each component, both neuroendocrine and non-neuroendocrine, to account for a minimum of 30% of the tumor mass.MethodsPatients after surgery resection and diagnosed at microscopy evaluation with pure gallbladder neuroendocrine carcinoma (GBNEC), gallbladder mixed adeno-neuroendocrine carcinoma (GBMANEC, GBNEC≥30%), and gallbladder carcinoma mixed with a small fraction of GBNEC (GBNEC &lt;30%) between 2010 and 2022 at West China Hospital of Sichuan University were collated for the analyses. Demographic features, surgical variables, and tumor characteristics were evaluated for association with patients’ overall and recurrence-free survival (OS and RFS).ResultsThe study included 26 GBNEC, 11 GBMANEC, 4 gallbladder squamous-cell carcinoma (GBSCC), and 7 gallbladder adenocarcinoma (GBADC) mixed with a small fraction of GBNEC. All patients had stage III or higher tumors (AJCC8th edition). The majority of included patients (79.17%) underwent curative surgical resection (R0), with only ten patients having tumoral resection margins. In the analysis comparing patients with GBNEC percentage (GBNEC≥30% vs. GBNEC&lt;30%), the basic demographics and tumor characteristics of most patients were comparable. The prognosis of these patients was also comparable, with a median OS of 23.65 months versus 20.40 months (P=0.13) and a median RFS of 17.1 months versus 12.3 months (P=0.24). However, patients with GBADC or GBSCC mixed with GBNEC &lt;30% had a statistically significant decreased OS and RFS (both P&lt;0.0001)) compared with GBNEC and GBMANEC. Patients with GBNEC who exhibited advanced tumor stages and lymphovascular invasion had a higher risk of experiencing worse overall survival (OS) and recurrence-free survival (RFS). However, a 30% GBNEC component was not identified as an independent risk factor.ConclusionPatients with GBNEC were frequently diagnosed at advanced stages and their prognosis is poor. The 30% percentage of the GBNEC component is not related to the patient’s survival.
Effect of bariatric surgery in the body burden of persistent and non-persistent pollutants: longitudinal study in a cohort of morbidly obese patients
Authors: Díaz-González B. Vanessa , Ramos-Luzardo Álvaro , Henríquez-Hernández Luis Alberto , Serra-Majem Lluis , Bautista-Castaño Inmaculada , Acosta-Dacal Andrea , Luzardo Octavio P. , Hernández-García Elisabeth , Cornejo-Torre Judith , Hernández-Hernández Juan Ramón , Fernández-Valerón Pilar 
Published: July 2024

IntroductionObesity is a pathological state that involves the dysregulation of different metabolic pathways and adipose tissue cells, constituting a risk factor for the development of other diseases. Bariatric surgery is the most effective treatment. The study of the behavior of pollutants in situations of extreme weight loss can provide biomonitoring information and tools to manage diseases of environmental etiology.AimTo determine the prevalence of serum persistent and non-persistent pollutants in obese patients subjected to bariatric surgery and analyze the impact of sociodemographic variables on these changes.MethodsGC-MS/MS and UHPLC-MS/MS were utilized to determine the detection rates and concentrations of 353 compounds, including persistent organic pollutants (POPs), pesticides, pharmaceuticals, and rodenticide, in serum samples of 59 obese patients before and after undergoing bariatric surgery.ResultsDetection rates of p,p’-DDE, HCB, β-HCH, naphthalene, phenanthrene and PCB congeners 138, 153 and 180 significantly increased due to surgery-induced weight loss. Serum levels of p,p’-DDE, PCB-138, PCB-153 and PCB-180 also increased after surgery. Correlations between naphthalene levels, weight loss, variation of total lipids and time after surgery were found. Additionally, correlations were observed between concentrations of PCB-138 and weight loss, and between phenanthrene levels and reduction of total lipids. No statistically significant differences were observed for other groups of contaminants, pharmaceuticals and other chemicals included in the quantification methods.ConclusionsIncrement of POPs was observed after bariatric surgery. Serum concentrations of POPs after surgery were influenced by adiposity-related variables. Although biomonitoring studies show a decreasing tendency of exposure, rapid weight loss leads to an increase of circulating POPs. Further research on the interplay between adipose tissue, POPs and peripheral organs is required.
CD4+CCR5+ T cells and CCL3+ mast cells are increased in the skin of patients with chronic spontaneous urticaria
Authors: Mubariki Raeda , Samara Reem , Gimenez-Arnua Anna Maria , Maurer Marcus , Bejar Jacob , Toubi Elias , Vadasz Zahava 
Published: July 2024

BackgroundThe proximity of activated T cells and mast cells in the lesional skin of patients with chronic spontaneous urticaria (CSU) is held to contribute to the development of wheals and angioedema. In a previous study, we demonstrated that increased IL-17 expression in T cells and mast cells in skin lesions of patients with CSU is associated with T/mast cell proximity, but the mechanisms that drive T cell/mast cell co-localization remain unknown.ObjectivesTo assess if chemokines expressed in lesional CSU skin contribute to T cell/mast cell proximity.Patients and methodsBiopsies from lesional CSU skin were compared to biopsies from healthy skin for expression of CCR5 and its ligand CCL3 by CD4+ T cells and mast cells, respectively.ResultsNumbers of CCR5-positive CD4+ T cells in lesional CSU skin were significantly increased as compared to healthy normal skin (p &lt; 0.0001). The number of mast cells expressing CCL3 (ligand for CCR5) in CSU skin was also increased (p &lt; 0.0002) and significant association with T-cell close proximity (p &lt; 0.0001) is noticed.ConclusionsThe close proximity of T cells and mast cells in the skin of severe CSU may be driven, at least in part by increased CCR5 and CCL3 expression. Therapies that target CCL3 interaction with CCR5 should be assessed for their effects in CSU.
Morphological and functional abnormalities of ophthalmic artery in patients with ophthalmic vascular accidents
Authors: Zhao Benqi , Ji Yicong , Xu Yangyang , Su Wei , Si Shancheng 
Published: July 2024

BackgroundBy observing and comparing the morphological and functional differences of the ophthalmic artery (OA) in patients with ocular vascular accidents (OVAs) due to iatrogenic embolism or non-iatrogenic occlusion, we propose a classification system based on the characteristics of OA on invasive digital subtraction angiography (DSA).MethodsAll patients undergoing ophthalmic arterial DSA within 1 week after the OVAs between January 2017 and December 2021 were enrolled and divided into different types, and the differences between iatrogenic embolism and non-iatrogenic occlusion categories were compared.ResultsA total of 27 eyes of 27 patients were included in this study. Based on the results of carotid/intracranial arterial DSA, the morphological and functional abnormalities of OA with OVAs can be divided into five types. The proportion of males (7.14%), ocular ischemic syndrome (OIS) (0.00%) and neovascular glaucoma (NVG) (0.00%) in the iatrogenic embolism category was significantly lower than that (84.62, 61.54, and 69.23%, respectively) of the non-iatrogenic occlusion category (p &lt; 0.001, p = 0.001, p &lt; 0.001, respectively). However, the proportion of no light perception (NLP) (100%), anterior segment ischemia (ASI) (71.43%), and orbital involvement (ophthalmoplegia and ptosis, 42.86%) eventually occurring in the former was significantly greater than that in the latter (23.08, 0.00, 0.00%, respectively) (p &lt; 0.001, p &lt; 0.001, p = 0.010, respectively).ConclusionOcular vascular accidents can be divided into five types based on the characteristics of OA on DSA.
Grouting technique—combining transvenous Onyx and coils for the embolization of complex non-cavernous intracranial dural arteriovenous fistulas
Authors: Chen Ching-Chang , Chen Chun-Ting , Wu Yi-Ming , Yeap Mun-Chun , Chen Yao-Liang , Wong Ho-Fai 
Published: July 2024

ObjectiveIncomplete occlusion of cerebral dural arteriovenous fistula (DAVF) may lead to fistula recurrence and rebleeding, which may necessitate several embolizations and lead to worse clinical outcomes. Herein, we describe a grouting technique for endovascular embolization and its outcomes in a series of patients with complex intracranial DAVF.MethodsA total of 20 patients with aggressive type or symptomatic intracranial non-cavernous DAVF underwent endovascular transvenous embolization combining detachable coils and Onyx. Two microcatheters were positioned either in the distal segment of the involved sinus or near the draining veins. To achieve tight occlusion of the involved sinus, coils were carefully delivered through the first microcatheter, starting from the distal segment and then to the proximal segment. Next, Onyx was injected through the second microcatheter to reinforce and fill (grout) the interspace of coil mass and gradually refluxed to the mural channels and para-sinus cortical veins until the fistula was completely occluded.ResultsSuccessful embolization was achieved in all 20 patients. The initial angiographic results revealed the achievement of complete occlusion in 19 patients (95%). At the postembolization follow-up, complete obliteration of the fistula was achieved in all patients (100%). No symptom or angiographic recurrence was observed at the 2- to 5-year follow-ups. No patient required additional embolization or stereotactic radiosurgery.ConclusionThe proposed grouting technique combining detachable coils and Onyx appears to be promising for the elimination of complex intracranial non-cavernous DAVFs.
A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging
Authors: Maccioni Lucia , Michelle Carranza Mellana , Brusaferri Ludovica , Silvestri Erica , Bertoldo Alessandra , Schubert Julia J. , Nettis Maria A. , Mondelli Valeria , Howes Oliver , Turkheimer Federico E. , Bottlaender Michel , Bodini Benedetta , Stankoff Bruno , Loggia Marco L. , Veronese Mattia 
Published: July 2024

IntroductionRecent evidence suggests the blood-to-brain influx rate (K1) in TSPO PET imaging as a promising biomarker of blood–brain barrier (BBB) permeability alterations commonly associated with peripheral inflammation and heightened immune activity in the brain. However, standard compartmental modeling quantification is limited by the requirement of invasive and laborious procedures for extracting an arterial blood input function. In this study, we validate a simplified blood-free methodologic framework for K1 estimation by fitting the early phase tracer dynamics using a single irreversible compartment model and an image-derived input function (1T1K-IDIF).MethodsThe method is tested on a multi-site dataset containing 177 PET studies from two TSPO tracers ([11C]PBR28 and [18F]DPA714). Firstly, 1T1K-IDIF K1 estimates were compared in terms of both bias and correlation with standard kinetic methodology. Then, the method was tested on an independent sample of [11C]PBR28 scans before and after inflammatory interferon-α challenge, and on test–retest dataset of [18F]DPA714 scans.ResultsComparison with standard kinetic methodology showed good-to-excellent intra-subject correlation for regional 1T1K-IDIF-K1 (ρintra = 0.93 ± 0.08), although the bias was variable depending on IDIF ability to approximate blood input functions (0.03–0.39 mL/cm3/min). 1T1K-IDIF-K1 unveiled a significant reduction of BBB permeability after inflammatory interferon-α challenge, replicating results from standard quantification. High intra-subject correlation (ρ = 0.97 ± 0.01) was reported between K1 estimates of test and retest scans.DiscussionThis evidence supports 1T1K-IDIF as blood-free alternative to assess TSPO tracers’ unidirectional blood brain clearance. K1 investigation could complement more traditional measures in TSPO studies, and even allow further mechanistic insight in the interpretation of TSPO signal.
Familial occurrence of imperforate hymen in premature monozygotic twins and their mother: a case report and literature review
Authors: Chua Bernadine Han Ern , Amin Zubair , Ng Yvonne Peng Mei 
Published: July 2024

BackgroundImperforate hymen is an uncommon obstructive anomaly of the developing female reproductive tract. There are occasional case reports of imperforate hymen occurring in family clusters, suggesting a plausible familial mode of inheritance. We describe a set of monozygotic premature twins with imperforate hymen noted at birth, whose mother was diagnosed with the same condition as a teenager. We also elucidate the likely underlying mode of inheritance of imperforate hymen.MethodWe utilized the CARE (Case Report) guideline in reporting the cases.Case presentationThese are monozygotic twins born prematurely at 30 weeks of gestation, noted at birth to have bulging cyst-like structures protruding from their vaginas. The twins were not dysmorphic and did not have any other congenital malformations. Over the next few weeks, these cyst-like structures (mucoceles) became less prominent. The genital anomaly was diagnosed as imperforate hymen. Their mother was also diagnosed with an imperforate hymen when she was 12 years old and was treated with hymenectomy.DiscussionThis unique occurrence of imperforate hymen in a set of premature monozygotic twins and their mother suggests a plausible autosomal or X-linked dominant mode of inheritance. Given the role of genetic inheritance in imperforate hymen development, it is important to screen female relatives of an index case for this genital anomaly.
Association between heavy metals exposure and persistent infections: the mediating role of immune function
Authors: Zhang Huiling , Wang Juan , Zhang Kunlun , Shi Jianyang , Gao Yameng , Zheng Jingying , He Jingtong , Zhang Jing , Song Yang , Zhang Ruifei , Shi Xuening , Jin Lina , Li Hui 
Published: July 2024

IntroductionPersistent infections caused by certain viruses and parasites have been associated with multiple diseases and substantial mortality. Heavy metals are ubiquitous environmental pollutants with immunosuppressive properties. This study aimed to determine whether heavy metals exposure suppress the immune system, thereby increasing the susceptibility to persistent infections.MethodsUsing data from NHANES 1999–2016, we explored the associations between heavy metals exposure and persistent infections: Cytomegalovirus (CMV), Epstein–Barr Virus (EBV), Hepatitis C Virus (HCV), Herpes Simplex Virus Type–1 (HSV–1), Toxoplasma gondii (T. gondii), and Toxocara canis and Toxocara cati (Toxocara spp.) by performing logistic regression, weighted quantile sum (WQS) and Bayesian kernel machine regression (BKMR) models. Mediation analysis was used to determine the mediating role of host immune function in these associations.ResultsLogistic regression analysis revealed positive associations between multiple heavy metals and the increased risk of persistent infections. In WQS models, the heavy metals mixture was associated with increased risks of several persistent infections: CMV (OR: 1.58; 95% CI: 1.17, 2.14), HCV (OR: 2.94; 95% CI: 1.68, 5.16), HSV–1 (OR: 1.25; 95% CI: 1.11, 1.42), T. gondii (OR: 1.97; 95% CI: 1.41, 2.76), and Toxocara spp. (OR: 1.76; 95% CI: 1.16, 2.66). BKMR models further confirmed the combined effects of heavy metals mixture and also identified the individual effect of arsenic, cadmium, and lead. On mediation analysis, the systemic immune inflammation index, which reflects the host’s immune status, mediated 12.14% of the association of mixed heavy metals exposure with HSV–1 infection.DiscussionThe findings of this study revealed that heavy metals exposure may increase susceptibility to persistent infections, with the host’s immune status potentially mediating this relationship. Reducing exposure to heavy metals may have preventive implications for persistent infections, and further prospective studies are needed to confirm these findings.
Deformation Estimation of Textureless Objects from a Single Image
Authors: Adli Sahand Eivazi , Pickard Joshua K. , Sun Ganyun , Dubay Rickey 
Published: July 2024

Deformations introduced during the production of plastic components degrade the accuracy of their 3D geometric information, a critical aspect of object inspection processes. This phenomenon is prevalent among primary plastic products from manufacturers. This work proposes a solution for the deformation estimation of textureless plastic objects using only a single RGB image. This solution encompasses a unique image dataset of five deformed parts, a novel method for generating mesh labels, sequential deformation, and a training model based on graph convolution. The proposed sequential deformation method outperforms the prevalent chamfer distance algorithm in generating precise mesh labels. The training model projects object vertices into features extracted from the input image, and then, predicts vertex location offsets based on the projected features. The predicted meshes using these offsets achieve a sub-millimeter accuracy on synthetic images and approximately 2.0 mm on real images.
Ernest Hemingway: Way of Life, Disease, and Creative Works from the Point of View of Modern Psychiatrist
Authors: Евсегнеев Р.А. 
Published: July 2024

В статье предпринята попытка с использованием имеющихся в литературе данных оценить глазами современного отечественного психиатра данные психиатрического анамнеза, характер и динамику психических и поведенческих расстройств великого американского писателя Эрнеста Хемингуэя, обозначить и сгруппировать их в форму предполагаемого психиатрического диагноза согласно критериям Международной классификации болезней 10-го пересмотра (МКБ-10), а также исследовать предпринятые в данном случае диагностические и лечебные мероприятия, сравнив их с современными стандартами и возможностями.
In the article an attempt is made to evaluate through the point of view of a today’s home psychiatrist the data of psychiatric history, nature and dynamics of mental and behavioral disorders of the great American writer Ernest Hemingway, to designate and group them in the form of a presumed psychiatric diagnosis according to the criteria of the ICD-10, as well as to study the diagnostic and therapeutic measures taken in this case, comparing them with modern standards and possibilities.
The Influence of Harmonic Sound on the Clinical Picture of Recurrent Depressive Disorder
Authors: Григорьева Е.А. , Дьяконов А.Л. , Лобанова И.В. 
Published: July 2024

Актуальность темы обусловлена необходимостью поиска новых, безопасных методов терапии депрессий. Использовано новое направление в виде комплексной обратной связи на коррекцию патологически устойчивого состояния (рекуррентные депрессивные расстройства) гармоническим звучанием в соответствии с экстремумами максимум и минимум с коэффициентом кратности 2n. Обследовано 86 практически здоровых людей и 88 пациентов с депрессией. Приводятся данные факторного анализа клинических и ЭЭГ данных. В результате исследования установлена ранее неизвестная закономерность реакции системной организации биопотенциалов мозга человека на гармоническое звучание, в результате которого в большинстве случаев наступило ослабление или устранение депрессивного расстройства. Выделены «жесткое звено» и «гибкие звенья» системной организации клинических симптомов, «гибкие звенья» нейрофизиологической системы. Нейрофизиологическое «жесткое звено» установить не удалось.
The relevance of the topic is due to the need for new, safe methods of treating depression. The work uses a new direction in the form of complex feedback for the correction of a pathologically stable state (recurrent depressive disorders) with harmonic sound in accordance with the maximum and minimum extrema with a multiplicity factor of 2n. 86 practically healthy people and 88 patients with depression were examined. Data from factor analysis of clinical and EEG data are presented. As a result of the study, a previously unknown pattern of the reaction of the systemic organization of biopotentials of the human brain to harmonic sound was established, which resulted in the weakening or elimination of depressive disorder in most cases. The "hard link" and "flexible links" of the systemic organization of clinical symptoms, and the "flexible links" of the neurophysiological system are identified. The neurophysiological "hard link" could not be established.
Aggressive Behavior of Patients in a Psychiatric Hospital: Results of a Survey of Medical Staff
Authors: Скугаревская М.М. , Ходжаев А.В. , Осипчик С.И. , Павлова Н.А. , Тихонович Т.В. , Скугаревский А.О. , Сачек В.И. 
Published: July 2024

Психомоторное возбуждение, агрессивное поведение людей с психическими расстройствами являются частым поводом для госпитализации в психиатрический стационар. Методом анонимного анкетирования опрашивались сотрудники клинических отделений Республиканского научно-практического центра психического здоровья на предмет их опыта работы с такими пациентами. Всего в опросе приняло участие 296 человек. Анкета включала вопросы по частоте встречаемости психомоторного возбуждения, физической и вербальной агрессии со стороны пациентов, способам оценки риска агрессивного поведения, организационным подходам профилактики агрессивных/насильственных действий пациентов. Анкета для врачей содержала дополнительные вопросы по медикаментозному лечению. С проявлениями вербальной агрессии со стороны пациентов за последний год сталкивались 90,4% респондентов. С проявлениями физической агрессии – 69,5% респондентов. Пути улучшения работы с агрессивными пациентами сотрудники психиатрического стационара видят в первую очередь в улучшении организационных аспектов работы.
Psychomotor agitation and aggressive behavior of people with mental disorders are a common reason for hospitalization in a psychiatric hospital. Using an anonymous survey method employee of the clinical departments of the Republican Scientific and Practical Center for Mental Health were surveyed about their experience of working with such patients. A total of 296 people took part in the survey. The questionnaire included questions on the frequency of occurrence of psychomotor agitation, physical and verbal aggression from the patients, instruments used for assessing the risk of aggressive behavior, and organizational approaches for preventing aggressive/violent actions of patients. The questionnaire for doctors contained additional questions about pharmacological treatment. 90.4% of respondents noted cases of verbal aggression towards them from patients over the past year. Cases of physical aggression against them were noted by 69.5% of respondents. Psychiatric hospital staff noted ways to improve work with aggressive patients by improving the organizational aspects of their work.