bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nucleobindin 2 expression is an independent prognostic factor for clear cell renal cell carcinoma
Authors: Qi Can , Ma Hui , Zhang Hong‐Tuan , Gao Jing‐Da , Xu Yong 
Published: October 2014

AimsNucleobindin 2 (NUCB2) has been reported to play an important role in both tumorigenesis and cancer progression. This study aimed to examine the clinical significance of NUCB2 expression in clear cell renal cell carcinoma (ccRCC).Methods and resultsThe expression level of NUCB2 and its correlation with clinicopathological parameters was analysed in 188 ccRCC tissues and adjacent non‐cancerous tissues by immunohistochemistry. Samples from eight ccRCC patients were examined by Western blotting and quantitative real‐time polymerase chain reaction (qRT–PCR). Kaplan–Meier analysis and Cox proportional hazards regression models were used to investigate the correlation between NUCB2 expression and the prognosis of ccRCC patients. The expression level of NUCB2 was found to be significantly higher in ccRCC tumours compared to adjacent non‐cancerous tissues using immunohistochemistry, Western blotting and qRT–PCR. Moreover, high NUCB2 tumour expression was associated with high T stage and metastasis and shorter overall survival. Univariate and multivariate analysis confirmed that NUCB2 was an independent prognostic factor for overall survival.ConclusionsOur results show that NUCB2 plays an important role in tumorigenesis and progression and is a potential molecular biomarker for the diagnosis and targeted therapy of ccRCC.
Improvement of Luminescence Properties of Blue‐to‐Red Emitting NaCaBO3: Ce3+, Mn2+ Phosphor Prepared by Sol–Gel Method
Authors: Zhang Xinguo , Song Jiahui , Zhou Liya , He Pei , Gong Menglian 
Published: October 2014

Color‐tunable phosphors NaCaBO3: Ce3+, Mn2+ were synthesized by sol–gel (SG) and solid state (SS) method. SEM observation indicated that the microstructure of phosphor (SG) consisted of regular fine grains with an average size of about 5 μm. NaCaBO3: Ce3+, Mn2+ showed two emission bands: one at 425 nm for Ce3+ and another at 610 nm for Mn2+. NaCaBO3: Ce3+, Mn2+ (SG) exhibit higher energy‐transfer efficiency (90%) and higher Mn2+ quantum efficiency (80%) than SS samples, due to smooth surface, narrow size distribution, and improved homogeneity of sensitizer/activator ions. NaCaBO3: Ce3+, Mn2+ exhibits blue‐to‐red tunable color by changing Ce3+/Mn2+ ratio.
New graduate nurses in transition: A review of transition programmes and transition experiences within mental health care
Authors: Tingleff Ellen Boldrup , Gildberg Frederik Alkier 
Published: October 2014

AbstractResearch on experiences of transition into mental health‐care roles seems sparse, but it is vital in order to produce a comprehensive understanding of the transition into mental health‐care roles and to serve as a foundation for future research and development. The aim of the present study was to review existing research literature, and in doing so, investigate transition programmes for new graduate nurses (NGN) into mental health care, and their experiences of role transition and evaluations of participation in transition programmes. The literature review spans literature published after the year 2000. The literature search was conducted using the following databases: CINAHL, Psychology and Behavioral Sciences Collection, PsycINFO, and Pubmed. Search results consisting of 14 articles were analysed using thematic analysis. Results from the analysis showed four overall themes: nursing education, transition programmes and evaluations, working environment, and the NGN role. We conclude that it is not possible to produce a comprehensive understanding specifically concerning the transition programmes for NGN into mental health care, and that further research is necessary due to the limitations of this review.
‘Going into the unknown’: Experiences of male patients in secure settings during environmental transition
Authors: Parkes Jacqueline H. , Pyer Michelle , Ward Alison , Doyle Colin , Dickens Geoffrey L. 
Published: October 2014

AbstractLittle is known about the experiences of male patients in secure mental health and intellectual disability units during environmental transition. We interviewed patients before (n = 9) and after (n = 8) a side‐to‐side security transition from medium‐secure wards in an older building to new wards in a purpose‐built building. We inquired about transitional experiences in general and about this transition specifically. We examined interview transcripts and field notes using thematic analysis, and collated routine outcome data to gauge whether transition had obvious positive or negative effects. Qualitative analysis indicated three major themes (information, transition, and behaviour) and five overlapping subthemes (positive information sharing and consultation, concerns and anxieties about lack of information, life change and opportunity, home and sense of belonging, and potential conflict). Outcome data indicated little obvious change between first and second interviews. Expressed concerns of patients about transition were largely about tangible and practical issues, including changes to rules, including smoking and prohibited items. The results highlight the need for the development of supportive patient‐inclusion strategies, consistent and transparent communication processes, and a published timeframe during the planning and implementation phases of all types of transitional moves, including the side‐to‐side transfer of residents between accommodation buildings.
The impact of a national caries strategy in Greenland after 4 years
Authors: Ekstrand Kim R. , Qvist Vibeke 
Published: October 2014

Aims(1) To describe dental health – and financial goals to be achieved with a national caries strategy in Greenland (CSG) implemented in 2008; (2) to describe the principles of CSG; (3) to report caries outcome data for the 3‐and 9‐year‐olds in 1996, in 2008 (baseline), and in 2012; and (4) to assess the effect of CSG on the same age.Goals and ResultsAd (1) Caries status recorded ≥85% of the children; 3‐year‐olds in 2012:defs = 0 ≥ 80%, defs > 8 ≤ 5%; 9‐year‐olds in 2012: DMFS = 0 ≥ 80%;DMFS > 4 ≤ 5%. CSG should not increase the cost compared to the old programme. Ad (2) CSG focused on predetermined visits/examinations, risk‐related visits, oral health promotion, and predetermined fluoride and sealing policies. Ad (3) 75% and 88% of the total cohorts of 3‐ and 9‐year‐olds in 2012 were recorded, respectively. Seventy‐six percent of the 3‐year‐olds showed defs = 0 in 2012 compared to 64% in 2008 (P < 0.0001). DMFS = 0 data for the 9‐year‐olds were 65% vs 57% (P = 0.003). The cost for running CSG was comparable to the cost before 2008. Ad (4) The annual percentage increase of children with defs/DMFS = 0 after implementation of CSG was twice as high as during 1996–2008.ConclusionThe caries status improves significantly from 2008 to 2012 exemplified in the 3‐ and 9‐year‐olds without increasing the costs.
Human cardiac telocytes: 3D imaging by FIB‐SEM tomography
Authors: Cretoiu D. , Hummel E. , Zimmermann H. , Gherghiceanu M. , Popescu L. M. 
Published: October 2014

AbstractTelocyte (TC) is a newly identified type of cell in the cardiac interstitium (www.telocytes.com). TCs are described by classical transmission electron microscopy as cells with very thin and long telopodes (Tps; cellular prolongations) having podoms (dilations) and podomers (very thin segments). TCs' three‐dimensional (3D) morphology is still unknown. Cardiac TCs seem to be particularly involved in long and short distance intercellular signalling and, therefore, their 3D architecture is important for understanding their spatial connections. Using focused ion beam scanning electron microscopy (FIB‐SEM) we show, for the first time, the whole ultrastructural anatomy of cardiac TCs. 3D reconstruction of cardiac TCs by FIB‐SEM tomography confirms that they have long, narrow but flattened (ribbon‐like) telopodes, with humps generated by the podoms. FIB‐SEM tomography also confirms the network made by TCs in the cardiac interstitium through adherens junctions. This study provides the first FIB‐SEM tomography of a human cell type.
INDOLE‐3‐ACETIC ACID INDUCIBLE 17 positively modulates natural leaf senescence through melatonin‐mediated pathway in Arabidopsis
Authors: Shi Haitao , Reiter Russel J. , Tan Dun‐Xian , Chan Zhulong 
Published: October 2014

AbstractMelatonin (N‐acetyl‐5‐methoxytryptamine) functions as a ubiquitous modulator in multiple plant developmental processes and various stress responses. However, the involvement of melatonin in natural leaf senescence and the underlying molecular mechanism in Arabidopsis remain unclear. In this study, we found that the endogenous melatonin level was significantly induced in a developmental stage‐dependent manner, and exogenous melatonin treatment delayed natural leaf senescence in Arabidopsis. The expression level of AUXIN RESISTANT 3 (AXR3)/INDOLE‐3‐ACETIC ACID INDUCIBLE 17 (IAA17) was significantly downregulated by exogenous melatonin treatment and decreased with developmental age in Arabidopsis. Further investigation indicated that AtIAA17‐overexpressing plants showed early leaf senescence with lower chlorophyll content in rosette leaves compared with wild‐type plants, while AtIAA17 knockout mutants displayed delayed leaf senescence with higher chlorophyll content. Notably, exogenous melatonin‐delayed leaf senescence was largely alleviated in AtIAA17‐overexpressing plants, and AtIAA17‐activated senescence‐related SENESCENCE 4 (SEN4) and SENESCENCE‐ASSOCIATED GENE 12 (SAG12) transcripts might have contributed to the process of natural leaf senescence. Taken together, the results indicate that AtIAA17 is a positive modulator of natural leaf senescence and provides direct link between melatonin and AtIAA17 in the process of natural leaf senescence in Arabidopsis.
Histomorphometric evaluation of maxillary molar roots and surrounding periodontium following molar intrusion in rats
Authors: Choi Y. J. , Kim K. H. , Lee K. J. , Chung C. J. , Park Y. C. 
Published: October 2014

Structured AbstractObjectivesTo investigate periodontal tissue changes during and after molar intrusion in rats.Setting and Sample populationThe Department of Orthodontics at Yonsei University. Thirty 12‐week‐old male rats were assigned to 1 control and 5 experimental groups (n = 5 each).Materials and MethodsIn the experimental groups, two maxillary molars were intruded for 2 weeks; the control group underwent the same procedures without the intrusion force. After 2 weeks of intrusion, rats in one of the experimental groups and in the control group were killed. In the other four experimental groups, the new molar positions were either retained or not retained with an occlusal bite block for 1 or 2 weeks prior to euthanization. Histomorphometric analysis was performed for sulcus depth, osteoclast number per unit alveolar bone length, and root resorption area per unit root surface length.ResultsSulcus depth increased during intrusion (P < 0.05), but decreased after 2 weeks of retention (P < 0.05). The number of osteoclasts increased during intrusion (P < 0.05), but subsequently decreased regardless of the retention regime (P < 0.05). Root resorption area increased after molar intrusion, irrespective of the retention regimen, relative to that of the control group (P < 0.05) and was the greatest after 2 weeks of retention.ConclusionThese results indicated that root resorption occurred during and after molar intrusion and that the surrounding periodontium remodeled accordingly as tooth positions were altered, regardless of retention regime.
Α technique for atraumatic root extraction, immediate implant placement and loading in maxillary aesthetic zone
Authors: Tsirlis A.T. , Eliades A.N. , Georgopoulou‐Karanikola T.G. , Vasiloudi M.I. 
Published: October 2014

AbstractThe study aims to report a technique for the extraction of an anterior maxillary root with simultaneous immediate implant placement and immediate loading with provisional non‐functional restoration. Due to a root fracture of a maxillary lateral incisor (#22), a semilunar flap was utilised to create a bony window in the apical area of the tooth and gently extract the remaining portion of the root through the alveolar socket. This technique is recommended in cases of immediate implant placement in fresh extraction sites where coronal bony bridge is intact. Then an implant was placed and the apical bony defect was repaired with guided bone regeneration. The loading of the implant with a temporary implant restoration within 24 h was applied without functional occlusal contacts. The placement of the permanent restoration was scheduled for 6 months later. After 1 year, a clinical and radiographic examination showed a normal peri‐implant bone level and a successful aesthetic effect. Furthermore, after four years the patient was examined and the implant is still showing good functional and aesthetic outcome. The preservation of the coronal bony anatomy, periosteum and soft tissues during the immediate implant placement is a major contributing factor to a desired aesthetic effect, which is enhanced with the option of immediate non‐functional loading. The described surgical approach preserves the advantages of immediate implant placement in fresh extraction sites in the maxillary aesthetic zone without intrasulcular incision and mucoperiosteal flap elevation while minimising the bony injuries during the extraction of the tooth.
Two‐step transplantation for primary hyperoxaluria: A winning strategy to prevent progression of systemic oxalosis in early onset renal insufficiency cases
Authors: Sasaki Kengo , Sakamoto Seisuke , Uchida Hajime , Shigeta Takanobu , Matsunami Masatoshi , Kanazawa Hiroyuki , Fukuda Akinari , Nakazawa Atsuko , Sato Mai , Ito Shuichi , Horikawa Reiko , Yokoi Tadashi , Azuma Noriyuki , Kasahara Mureo 
Published: October 2014

AbstractSeveral transplant strategies for PH1 have been proposed, and LT is performed to correct the metabolic defects. The patients with PH1 often suffer from ESRD and require simultaneous LKT, which leads to a long wait due to the shortage of suitable organ donors. Five patients with PH1 underwent LDLT at our institute. Three of the five patients were under dialysis before LDLT, while the other two patients were categorized as CKD stage 3. An isolated LDLT was successfully performed in all but our first case, who had complicated postoperative courses and consequently died due to sepsis after retransplantation. The renal function of the patients with CKD stage 3 was preserved after LDLT. On the other hand, our second case with ESRD underwent successful LDKT six months after LDLT, and our infant case is waiting for the subsequent KT without any post‐LDLT complications after the early establishment of PD. In conclusion, a two‐step transplant strategy may be needed as a life‐saving option for patients with PH1 and may be possible even in small infants with systemic oxalosis. While waiting for a subsequent KT, an early resumption of PD should be considered from the perspective of the long‐term requirement of RRT.
Lifesaving liver transplantation for multi‐organ failure caused by Bacillus cereus food poisoning
Authors: Tschiedel Eva , Rath Peter‐Michael , Steinmann Jörg , Becker Heinz , Dietrich Rudolf , Paul Andreas , Felderhoff‐Müser Ursula , Dohna‐Schwake Christian 
Published: October 2014

AbstractBacillus cereus is a spore‐forming, gram‐positive bacterium that causes food poisoning presenting with either emesis or diarrhea. Diarrhea is caused by proteinaceous enterotoxin complexes, mainly hemolysin BL, non‐hemolytic enterotoxin (NHE), and cytotoxin K. In contrast, emesis is caused by the ingestion of the depsipeptide toxin cereulide, which is produced in B. cereus contaminated food, particularly in pasta or rice. In general, the illness is mild and self‐limiting. However, due to cereulide intoxication, nine severe cases with rhabdomyolysis and/or liver failure, five of them lethal, are reported in literature. Here we report the first case of life‐threatening liver failure and severe rhabdomyolysis in this context that could not be survived without emergency hepatectomy and consecutive liver transplantation.
The natural history of dementia
Authors: Kua Ee Heok , Ho Emily , Tan Hong Hee , Tsoi Chris , Thng Christabel , Mahendran Rathi 
Published: October 2014

AbstractThis review summarizes studies on the natural history of dementia with a focus on Alzheimer's disease and vascular dementia. Understanding the course of dementia is important not only for patients, caregivers, and health professionals, but also for health policy‐makers, who have to plan for national resources needed in the management of an increasing number of dementia cases. From the available published data, the life expectancy of elderly people with dementia is shorter than that of non‐demented elderly. Reports on survival after a diagnosis of dementia vary from 3 to 12 years. The wide variation is partly due to the diagnostic criteria used in the studies and the sites where they were conducted (i.e. hospitals, clinics, or homes). There is an apparent difference in survival between Alzheimer's disease patients with onset of illness before 75 years and those after 75 years: the younger patients have a longer life expectancy. However, there are conflicting data on survival (in years) comparing male and female patients and comparing patients of different ethnicities. For vascular dementia, published papers on life expectancy vary between 3 to 5 years. Vascular dementia appears to have a poorer prognosis than Alzheimer's disease. The stages of severity of dementia were compared in a follow‐up of a sample of Alzheimer's disease patients in Singapore, and the mean duration of the mild phase (clinical dementia rating 1) was 5.6 years, the moderate phase (clinical dementia rating 2) was 3.5 years, and the severe phase (clinical dementia rating 3) was 3.2 years. At the various phases of the disease, the demand on health‐care services and economic cost are different.
The reward positivity: From basic research on reward to a biomarker for depression
Authors: Proudfit Greg Hajcak 
Published: October 2014

AbstractFeedback indicating monetary loss elicits an apparent negative deflection in the event‐related potential (ERP) that has been referred to as the feedback error‐related negativity, medial frontal negativity, feedback‐related negativity, and feedback negativity—all conceptualizations that suggest a negative ERP component that is greater for loss than gain. In the current paper, I review a programmatic line of research indicating that this apparent negativity actually reflects a reward‐related positivity (RewP) that is absent or suppressed following nonreward. I situate the RewP within a broader nomological network of reward processing and individual differences in sensitivity to rewards. Further, I review work linking reductions in the RewP to increased depressive symptoms and risk for depression. Finally, I discuss future directions for research on the RewP.
Religion and the Japanese American Incarceration
Authors: Blankenship Anne M. 
Published: October 2014

AbstractAbundant scholarship analyzes the United States' incarceration of Japanese Americans during World War II, but the subject of religion in the camps and religious responses to the incarceration has been long overlooked. The government promised freedom of religion in the camps while encouraging Japanese Americans to consolidate worship into one Buddhist, one Catholic, and one Protestant church in each incarceration center. Incarcerees found strength through fellowship and religious faith. Outside of the camps, progressive Christians tried to alleviate the harms caused by the injustice and increase tolerance around the country. The field offers examples of early race relations work within American Protestantism and introduces the ways in which the government prioritized and attempted to enforce freedom of religion within a fabricated and restricted wartime environment. Further examination of these events will complement studies of 20th century liberal Christianity, American Buddhism, religious liberty and the state, the early civil rights movement, religion and World War II, and Asian American theology.
Investigation of dyeing behavior of oxidative dye in fine structures of the human hair cuticle by nanoscale secondary ion mass spectrometry
Authors: Kojima T. , Yamada H. , Saito Y. , Nawa T. , Isobe M. , Yamamoto T. , Aoki D. , Matsushita Y. , Fukushima K. 
Published: October 2014

Background/purposeIn oxidative coloring, the hair cuticle layers are not only the penetration pathway for active ingredients but also one of the most important dyeing regions. The dyeing mechanism of oxidative dyes in fine structures of the cuticle remains unclear. To investigate the dyeing behavior of oxidative dyes in fine structures of the cuticle, hair cross‐sections were analyzed by nanoscale secondary ion mass spectrometry (NanoSIMS).MethodsThe preparation method of hair cross‐section for NanoSIMS measurement was improved. Improved hair cross‐sections were analyzed using NanoSIMS.ResultsThe cuticle layer thickness of the hair cross‐section could be widened. It was confirmed that 12C− ions were more strongly detected from endocuticle than from other fine structures of cuticle. The NanoSIMS 12C− image and hue saturation intensity (HSI) D−/1H− ratio image of the hair, dyed with deuterium‐labeled oxidative dye, indicated that the endocuticle had a higher D−/1H− ratio than the other fine structures of the cuticle. It was substantiated that more colored chromophores were fixated in the endocuticle than in other fine structures of the cuticle.ConclusionThe dyeing behavior of oxidative dyes in fine structures of hair cuticle was substantiated by NanoSIMS analysis using the improved hair cross‐section preparation method.
Correlation of ABH blood group antigens secretion with Helicobacter pylori infection in Pakistani patients
Authors: Ansari Shazia Akbar , Khan Adnan , Khan Taseer Ahmed , Raza Yasir , Syed Sofia Ali , Akhtar Syed Shakeel , Kazmi Shahana Urooj 
Published: October 2014

AbstractObjectivesA and B blood group antigens are fucosylated carbohydrate present on human erythrocytes and body secretions. Their presence in body secretions depends on the expression of a dominant allele of secretor gene FUT2 and is correlated with susceptibility to various infectious and non‐infectious diseases. We investigated the correlation of blood group and ABH antigen secretion with Helicobacter pylori infection and gastroduodenal symptoms and analysed the distribution of babA gene among ABH secretors and non‐secretors.MethodsTwo hundred and ninety patients who underwent gastroduodenal endoscopy during 2011 to 2012 participated. Gastric biopsy, saliva and blood samples were obtained from every patient. Gastric biopsies were subjected to rapid urease test and PCR for the detection of H. pylori and babA gene. Blood grouping and ABH antigens secretions were determined by Lewis blood group phenotyping and haemagglutination inhibition test.Results50.34% of patients were ABH antigen secretors and 45.51% non‐secretors. Distribution analysis of blood group revealed that 40 blood group B, 67 blood group A 20 blood group O and 19 blood group AB patients secreted ABH antigens in saliva. Fifty‐six blood group O, 19 blood group B, 32 blood group A and 17 blood group AB patients were non‐secretors. Gastroduodenal complaints were common among non‐secretors. Sixty‐two percent of patients with a combination of duodenal ulcer and gastro‐oesophageal reflux and 54% of patients with gastritis were non‐secretors. Of 290 samples, 31.02% were positive for H. pylori. Thirty percent of these tested positive for babA gene; the majority belonged to non‐secretor blood group O.ConclusionsOur results suggest that the infection of H. pylori is correlated with ABO blood groups and blood group antigens secretion in body fluids.