bluuebunny/crossref_metadata_2025_split huggingface dataset:
Study of the intensity of postoperative pain after mine-explosive injury: a pilot study of different analgesics
Authors: Dmytriiev D. 
Published: August 2024

Background. Mine-explosive injuries, often associated with traumatic and complex circumstances, pose unique challenges in the field of surgical interventions (SI) and subsequent pain management. That is why the main goal of this study was to determine the safety and effectiveness of a single dose of dinalbuphine sebacate 150 mg/2 ml as a component of multimodal analgesia applied intramuscularly before reconstructive surgeries due to mine-explosive lesions. Materials and methods. A prospective, open, non-randomized clinical study was carried out with the participation of 15 patients with mine-explosive injuries, who were treated using dinalbuphine sebacate 150 mg/2 ml as a component of multimodal anesthesia for postoperative pain. All patients received a single dose of dinalbuphine sebacate 150 mg/2 ml intramuscularly using the Z-technique in the gluteal area 12–24 hours before surgery. The Visual Analogue Scale (VAS) with a range from 0 to 10 points (0 = no pain, 10 = the worst imaginable pain) was used as a tool for assessing the severity of the pain syndrome. The StataCorp 2023 program was used for statistical analysis. Stata Statistical Software: Release 18. College Station, TX: StataCorp LLC. Simple linear regression analysis was used to study the relationship between Injury Severity Score (ISS) and VAS. Results. No statistically significant relationship between ISS and VAS was found. The study showed that 6 h after SI, the level of pain significantly decreased in comparison with that 6–8 hours after the use of the drug and was not statistically significantly different from the indicators of the following four days: VAS 6 hours after SI vs. 12 hours after SI — p = 0.2500, VAS 6 hours after SI vs. 24 hours after SI — p = 1.0000, VAS 6 hours after SI vs. 48 hours after SI — p= 0.4531, VAS 6 hours after SI vs. 96 hours after SI — p= 0.2188. At the same time, a statistically significant difference was found between VAS 6 hours after SI vs. 120 hours after SI — p= 0.0010. Conclusions. The efficacy and favorable to-lerability of dinalbuphine sebacate as a component of multimodal analgesia in the setting of postoperative analgesia in patients after reconstructive surgical interventions caused by mine-explosive injuries was demonstrated.
A clinical case of surgical treatment of coronary heart disease against the background of concomitant pathology: infective endocarditis of the aortic valve, Gerbode defect and complete atrioventricular block
Authors: Zhurba O.O. , Smolii S.V. , Proshak O.V. , Pechenenko A.R. , Конодюк М.С. 
Published: August 2024

In many patients, mainly in the age group of 60–75 years, with coronary heart disease, valvular diseases, cardiac conduction disorders and other accompanying age-associated pathology are detected. This article presents a clinical case of a patient who was hospitalized with a primary diagnosis of myocardial infarction complicated by complete atrioventricular block. During the examination, a bicuspid aortic valve with stenosis of the second degree, subocclusion of the right coronary artery (95 %) were additionally revealed. The patient underwent emergency stenting of the right coronary artery and was implanted a temporary pacemaker. Due to persisted block after 10 days permanent pacemaker was implanted, but during further observation and examination, ultrasound and tomographic signs of infective endocarditis of the aortic valve were detected with an increase in the degree of its stenosis up to the third degree, abscess of the aortic root and interventricular septum and formation of left ventricular to right atrial shunt (Gerbode defect). The patient underwent aortic valve replacement, Gerbode defect repair with xenopericardial flaps, and pacemaker replacement with epicardial electrode implantation with good clinical results. Step-by-step diagnostic, therapeutic and surgical tactics are given.
DAMPAK PANDEMI COVID-19 TERHADAP FILANTROPI DI RUMAH SAKIT ISLAM YOGYAKARTA PDHI
Authors: Nurutama Bima Achmad 
Published: August 2024

DAMPAK PANDEMI COVID-19 TERHADAP FILANTROPI DI RUMAH SAKIT ISLAM YOGYAKARTA PDHIBima Achmad B.N.1, Laksono T.2, Jodi Visnu3. INTISARI Latar belakang:Pandemi COVID-19 mulai menjangkit seluruh dunia sejak tahun 2019 yang disebabkan oleh SARS CoV-2 dan ditetapkan sebagai Bencana Nasional Non-Alam. Salah satu upaya pemerintah untuk mencegah dan menurunkan angka transmisi COVID-19 yaitu dengan pembatasan aktivitas sosial. Kebijakan pemerintah dalam pembatasan sosial telah memberi dampak signifikan terhadap penurunan kunjungan rumah sakit sejak bulan Maret 2020. Berbagai upaya dilakukan oleh rumah sakit untuk bertahan di kondisi pandemi COVID-19, salah satunya dengan filantropi. RSIY PDHI mulai mengembangkan kegiatan filantropi sejak awal berdiri. Berbagai kegiatan filantropi yang saat ini dikembangkan terbagi dalam 5 kategori yaitu pendidikan, kesehatan, kemanusiaan, ekonomi, dan sosial. Pengelolaan dana filantropi RSIY PDHI berasal dari zakat, infaq, sedekah, dan wakaf (ZISWAF) yang masuk ke RSIY PDHI Peduli. RSIY PDHI Peduli merupakan lembaga dibawah Yayasan RSIY PDHITujuan: Mengidentifikasi dampak pandemi COVID-19 terhadap aktivitas filantropi di RSIY PDHI dan mengeksplorasi potensi filantropi di RSIY PDHI.Metode : Penelitian ini merupakan penelitian deskriptif dengan pendekatan kualitatif. Responden dipilih dengan cara purposive sampling. Dari masing-masing kategori responden akan dipilih sampel sebanyak 2-3 orang sampai tujuan penelitian tercapai. Analisis data penelitian dilakukan secara tematik. Hasil dan Pembahasan:Kunjungan rawat jalan dan rawat inap di beberapa RS area Sleman timur mengalami penurunan di bulan April 2020. Kondisi keuangan RSIY PDHI mengalami penurunan selama pandemi berlangsung. Dalam kegiatan filantropi RSIY PDHI terjadi penurunan jumlah infaq atau sedekah, namun jumlah zakat meningkat sejak awal terjadi pandemi. Donasi non tunai meningkat signifikan sebesar Rp 198.316.094. Total pengeluaran selama pandemi naik sebesar 160% dibandingkan periode sebelumnya. Berdasarkan analisa lingkungan bisnis internal dan eksternal untuk menggali potensi filantropi di RSIY PDHI, strategi jangka panjang dalam jangka waktu 10 (sepuluh) tahun kedepan RSIY PDHI Peduli akan menjadi Lembaga Amil Zakat Nasional dan membuat Pelayanan atau Fasilitas Pelayanan dari Wakaf atau Zakat. Sementara dalam jangka pendek 5 (lima) tahun kedepan adalah untuk merealisasikan pembuatan poliklinik gratis bagi masyarakat tidak mampu, dan memperluas kerja sama dengan mitra RSIY PDHI dalam kegiatan filantropi.Kesimpulan:Saat pandemi terjadi kenaikan pengeluaran rumah sakit dibandingkan kondisi sebelum pandemi namun terdapat peningkatan pemasukan dalam aktifitas filantropi, terutama dari donasi non tunai. Dengan dilaksanakannya kegiatan filantropi ini meningkatkan reputasi yang baik bagi RS Islam Yogyakarta PDHI. Kata Kunci: Donasi; Filantropi rumah sakit; Infaq; Pandemi COVID-19; Sedekah
Comparison of Obinutuzumab and Rituximab for Treating Primary Membranous Nephropathy
Authors: Hu Xiaofan , Zhang Muyin , Xu Jing , Gao Chenni , Yu Xialian , Li Xiao , Ren Hong , Wang Weiming , Xie Jingyuan 
Published: August 2024

Key Points

Obinutuzumab induced more remission than rituximab at 12 months in patients with primary membranous nephropathy.Obinutuzumab shared a similar safety profile as rituximab in patients with primary membranous nephropathy.

Background
This study compared the effectiveness and safety profiles of obinutuzumab and rituximab in the treatment of patients with primary membranous nephropathy (MN).

Methods
Patients with primary MN who had urine protein ≥3.5 g/24 hours and eGFR ≥30 ml/min per 1.73 m2 despite 6 months of angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker and treatment with obinutuzumab or rituximab were included and matched by propensity score (ratio: 1:2) on the basis of age, sex, urine protein, eGFR, and titers of Anti-Phospholipase A2 receptor (PLA2R) antibody. The primary outcome was defined as a combination of partial or complete remission at 12 months. Logistic regression models, Kaplan–Meier curves, and absolute risk differences were used to compare the therapeutic effectiveness and safety profiles of obinutuzumab and rituximab.

Results
Sixty-three patients with primary MN were included in the study, with 21 patients receiving obinutuzumab and 42 patients receiving rituximab. At 12 months, the primary outcome was achieved in 20 of 21 patients in the obinutuzumab group and 28 of 42 patients in the rituximab group (obinutuzumab versus rituximab: 95% versus 67%; odds ratio, 10.00; 95% confidence intervals, 1.21 to 82.35; P = 0.03). Moreover, patients in the obinutuzumab group acquired more complete remission (obinutuzumab versus rituximab: 38% versus 14%; odds ratio, 3.69; 95% confidence interval, 1.08 to 12.68; P = 0.04). In PLA2R-associated primary MN subgroup analyses, patients in the obinutuzumab group sustained lower CD19 B-cell counts (CD19 B-cell counts: median [interquartile range] 0 [0–6] cells/μl versus 20 [3–58] cells/μl, P = 0.002) and were more prone to achieve immunological remission (defined as PLA2R antibody <2 RU/ml) at 6 months (obinutuzumab versus rituximab: 92% [12 out of 13] versus 64% [16 out of 25], P = 0.06) than rituximab. Both treatment regimens were well tolerated.

Conclusions
Our study demonstrated that obinutuzumab is associated with higher odds of clinical remission compared with rituximab at 12 months, which may be due to higher immunological remission at 6 months with a similar safety profile in patients with primary MN.
Pengaruh Penggunaan E-Commerce, Inovasi Produk, Dan Kemampuan Menyusun Laporan Keuangan Terhadap Kinerja Operasional Pada Usaha Mikro Kecil Dan Menengah (UMKM ) Di Kabupaten Karangasem
Authors: Kusuma I Ketut Gede Kertha Kusuma , Ni Luh Gede Erni Sulindawati  
Published: August 2024

Penelitian ini bertujuan untuk mengentahui pengaruh Penggunaan e commerce, Inovasi produk dan kemampuan menyusun laporan keuangan terhdap kinerja operasional UMKM di kabupaten Karangasem. Penelitian ini adalah penelitian deskriptif dan asosiatif dengan pendekatan kuantitatif. Jenis data yang digunakan dalam penelitian ini adalah data kuantitatif merupakan data dalam bentuk angka dan dinyatakan dalam satuan hitung, data yang diperoleh dari hasil penyebaran kuesioner berupa skor angka. Sumber data dalam penelitian ini yaitu dana skunder dan data primer. Populasi yang digunakan adalam penelitian adalah UMKM di kabupaten Karangasem. Metode penentuan sampel menggunakan kreteria Random Sampling. Jumlah responden dalam penelitian ini 100 responden dari pengurus UMKM. Hasil uji menyatakan bahwa variabel Penggunaan e commerce berpengaruah positif dan signifikan terhadap Kinerja operasional UMKM, variabel Inovasi produk berpengaruh positif dan signifikan terhadap Kinerja operasional UMKM, dan variabel Kemampuan menyusun laporan keuangan berpengaruh positif dan signifikan terhadap Kinerja operasional UMKMdi Kecamatan Buleleng. Serta dalam uji koefisien determinasi (R2) menunjukkan hasil bahwa variabel Penggunaan e commerce (X1), Inovasi produk (X2), dan Kemampuan menyusun laporan keuangan (X3) mampu mempengaruhi Kinerja operasional UMKMdi Kecamatan Buleleng secara bersama-sama sebesar 63,9% sedangkan sisanya sebesar 36,1% dipengaruhi oleh variabel lain diluar regresi.
Pengaruh Rasio Keuangan Terhadap Perubahan Laba pada perusahaan Sub Sektor Pariwisata, Hotel dan Restoran dalam Transisi New Normal
Authors: Sigit Wahyudi Sigit Wahyudi , Dewi Putu Eka Dianita Marvilianti 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh rasio keuangan terhadap perubahan laba pada perusahaan sub sektor pariwisata, hotel dan restoran dalam transisi new normal. Penelitian ini merupakan penelitian yang menggunakan metode kuantitatif. Metode kuantitatif diartikan sebagai metode penelitian yang berlandaskan pada filsafat positivisme, digunakan untuk meneliti pada populasi atau sampel tertentu, pengumpulan data menggunakan instrumen penelitian, analisis data bersifat kuantitatif atau statistik, dengan tujuan untuk mengaju hipotensis yang telah ditetapkan. Data yang digunakan yaitu data sekunder yang diperoleh dari laporan keuangan perusahaan yang dapat diakses pada website resmi Bursa Efek Indonesia yaitu www.idx.co.id untuk periode 2022 sampai dengan 2023 dalam transisi new normal. Populasi dalam penelitian ini menggunakan sub sektor pariwisata, hotel dan restoran yang tercatat di Bursa Efek Indonesia (BEI) sebanyak 41 perusahaan. Teknik pengambilan sampel yang digunakan yaitu purposive sampling dan mendapatkan jumlah sampel sebanyak 32 perusahaan. Data yang diperoleh selanjutnya diuji dan dianalisis dengan uji analisis statistik deskriptif, uji asumsi klasik dan pengujian hipotesis menggunakan software SPSS versi 25. Dari analisis data tersebut menunjukan hasil penelitian bahwa : (1) current ratio tidak berpengaruh terhadap perubahan laba (2) debt to equity ratio tidak berpengaruh terhadap perubahan laba (3) total asset turnover berpengaruh positif terhadap perubahan laba (4) operating profit margin berpengaruh positif terhadap perubahan laba.
Uji Kualitas Red Velvet Cake Dengan Menggunakan Ekstrak Umbi Bit (Beta Vulgaris) Sebagai Bahan Pewarna
Authors: Putri Ni Putu Yulita Astira Eka , Damiati Damiati , Marsiti Cokorda Istri Raka 
Published: August 2024

Tujuan penelitian ini adalah untuk mengetahui kualitas cake red velvet dengan menggunakan ektrak umbi bit sebagai bahan pewarna dilihat dari aspek warna, tekstur, dan rasa. Panelis dalam penelitian ini berjumlah 15 orang yang terdiri dari guru tata boga, chef, dan dosen tata boga. Metode pengumpulan data yang digunakan pada penelitian ini adalah observasi kemudian melakukan uji organoleptik pada panelis dengan menggunakan 3 tingkatan yaitu baik, cukup, dan tidak baik. Data analisis yang dilakukan dengan menggunakan teknik deskriptif kuantitatif. Hasil penelitian ini meliputi (1) dari segi rasa cake baik yang menggunakan 100%, 75%, dan 50% ekstrak umbi bit memiliki rasa yang manis. (2) dari segi warna cake dengan menggunakan 100% ekstrak umbi bit memiliki warna coklat, cake dengan menggunakan 75% ekstrak umbi bit memiliki warna merah pucat, cake dengan menggunakan 50% ekstrak umbi bit memiliki warna merah cerah. (3) dari segi tekstur cake dengan menggunakan 100%, 75%, dan 50% ekstrak umbi bit memiliki tekstur yang lembut, padat, dan tidak berongga. Dari ketiga eksperimen dengan menggunakan ekstrak umbi bit dilihat dari segi warna yang mendekati dari control yaitu produk cake dengan menggunakan 50% ekstrak umbi bit.Kata kunci: Uji Kualitas, Cake Red Velvet, Ekstrak Umbi Bit, Warna, Tekstur, Rasa The purpose of this study was to determine the quality of red velvet cake using beet root extract as a coloring agent in terms of color, texture, and taste. The panelists in this study were 25 people consisting of culinary teachers, chefs, and culinary lecturers. The data collection method used in this study was observation through organoleptic tests on panelists using 3 levels, namely good, adequate, and insufficient. Data analysis was carried out using quantitative descriptive techniques. The results of this study include (1) in terms of good cake taste using 100%, 75%, and 50% beet root extract has a sweet taste. (2) In terms of color, the cake using 100% beet root extract has a brown color, cake using 75% beetroot extract has a pale red color, cake using 50% beet root extract has a bright red color. (3) in terms of cake texture using 100%, 75% and 50% beet root extract has a soft, dense, and not hollow texture. From the three experiments using beet root extract, it was seen in terms of color that was closer to the control, namely the cake product using 50% beet root extract. Keywords: quality test, red velvet cake, beet root extract, colour, texture, taste
Pengembangan Roll Cake Dengan Motif Prada Bunga Bakung Khas Bali
Authors: Ni Luh Vera Dwiyani  , Marsiti Cokorda Istri Raka , Ariani Risa Panti 
Published: August 2024

Abstrak
Penelitian ini bertujuan untuk (1) mendeskripsikan tahapan pengembangan roll cake, (2) mendeskripsikan kelayakan produk roll cake dan (3) mendeskripsiskan uji diperluas produk roll cake motif prada bunga bakung khas Bali. Penelitian ini merupakan penelitian pengembangan R&D dengan model pengembangan 4D: define, design, development, dan dissemination. Teknik pengumpulan data dalam penelitian ini menggunakan metode observasi dengan subjek penelitian terdiri dari panelis ahli desain dan 50 orang panelis diperluas. Hasil data dianalisis secara deskriptif kuantitatif. Hasil penelitian ini meliputi : (1) Tahapan define perencanaan produk meliputi analisis awal dan resep acuan roll cake batik, tahapan design motif roll cake diinovasikan dengan motif prada bunga bakung khas Bali yang bertemakan flora berupa bunga, daun dan batang, tahap development dilakukan proses pembuatan atau perealisasian motif pada roll cake pada tahap ini juga dilakukan uji validasi produk oleh ahli desain dilihat pada aspek warna dan bentuk motif prada bunga bakung dan tahap terakhir yaitu dissemination pada tahap ini dilakukan uji kesukaan. (2) Pada uji kelayakan dari segi warna dan bentuk motif mendapatkan kualifikasi ”Sangat Baik”, dari segi warna mendapatkan skor rata-rata 5 dengan katagori ”Sangat Baik” dan dari segi bentuk motif mendapatkan skor rata-rata 4,5 dengan katagori ”Sangat Baik”. (3) Pada uji diperluas dari segi warna dan bentuk motif mendapatkan kualifikasi ”Sangat Suka”, dari segi warna mendapatkan skor rata-rata 4,76 dengan katagori ”Sangat Suka” dan pada aspek bentuk motif mendapatkan skor rata-rata 4,82 dengan kategori ”Sangat Suka” dari kedua penilaian menunjukan bahwa motif prada bunga bakung khas Bali layak untuk di terapkan pada roll cake dan dapat diterima oleh masyarakat.
Kata kunci: model pengembangan 4D, roll cake, prada bunga bakung
UJI USABILITY FUNGSI APLIKASI WEB SISTEM INFORMASI DENGAN USE QUESTIONNAIRE (STUDI KASUS: APLIKASI WEB SISTEM INFORMASI TIRAS DAN TRANSAKSI BAHAN AJAR)
Authors: Sufandi Unggul Utan , Priono Mochamad , Aprijani Dwi Astuti , Wicaksono Bagus Arif , Trihapningsari Denisha 
Published: August 2024

The web Application For Information Systems And Transactions For Teaching Materials (SITTA) is an application that is used to support operational activities in the distribution service of teaching materials at State Universities of the Open University. The SITTA web application can be accessed on the https://distributions.ut.ac.id/ website with internal access to UT at the center and UPBJJ (Distance Learning Program Unit). The SITTA web application was used by UT employees as users of the SITTA web application, which was used recently because the SITTA web application was only implemented in early 2018. Therefore, it was deemed necessary to test its usability. This is to assess the success of the usability aspect of an information system application while at the same time knowing that the application can be useful and has been by its function or not for user needs. One of the tests that can be done is usability testing. This test is carried out using the USE Questionnaire method using 4 aspects of testing. 4 aspects tested are aspects of Usefulness, Satisfaction, and Ease of Use. The purpose of this paper is to determine user acceptance of the SITTA web application based on usability criteria. This research is a quantitative descriptive type that is carried out on users of the SITTA web application by distributing a USE Questionnaire consisting of 30 questions and using 5 points of assessment on a Likert Scale. This study obtained the results of measuring the usability of the SITTA web application with a score of 88.10% on the measurement of the usefulness aspect, 78.29% on the ease of use, 82.14% on the ease of learning, and 81.26% on the satisfaction aspect. satisfaction.
DESAIN DATA CENTER PERBANKAN DENGAN METODE NETWORK DEVELOPMENT LIFE CYCLE (NDLC) (STUDI KASUS PT. BPR XYZ)
Authors: Yudik I Wayan Yudik Pradnyana , Aryanto Kadek Yota E. , Gunadi I G. Aris 
Published: August 2024

The development of information technology has produced a variety of products and services that are very dynamic following the needs of the community, including in the banking sector. To be able to run this electronic system, data center infrastructure is an important element that must be owned by banking institutions. The same thing is needed by PT BPR XYZ, which currently does not manage its data center properly. The current condition of the network topology between offices is not good so there is a need for a proposed topology. The data center security design in this research uses the Open Enterprise Security Architecture (O-ESA) framework. The framework is focused on the use of Security Technology Architecture in the security services architecture section. The method used in this research is Network Development Life Cycle (NDLC) as a reference to the data center security development process at PT BPR XYZ. This research recommends an inter-office network design. The design given has gone through a simulation process to prove that the proposed design is better than the existing design, so that the proposed design can be applied to data center security at PT BPR XYZ. The proposed topology uses a dedicated network as a virtual private network (VPN) server and network security using a traditional firewall. The proposed topology supports high avalability with failover techniques.
Keywords : Design, Data Center, Banking, Security Technology Architecture, Network Development Life Cycle
Kreativitas Guru Memanfaatkan Lingkungan Sekitar Dalam Pembelajaran Tahfidz Alquran
Authors: Lisa Mona , Murniyetti Murniyetti 
Published: August 2024

The surrounding environment provides a lot of knowledge and experience for the development of students but not all teachers can realize this. This study aims to determine and analyze the creativity of teachers in utilizing the surrounding environment in learning Quran memorization for fifth-grade students at Buah Hati Padang Integrated Islamic Elementary School. This research uses a qualitative method with a case study approach. Data sources were taken from informants through in-depth interviews consisting of principals, teachers, and students selected using a purposive sampling technique. All interview results were then analyzed systematically using the Milles & Hubberman Interactive Analysis Model technique with the Thematic Analysis method. Overall, the results of the research analysis show that there are three findings in the theme of teacher creativity in utilizing the surrounding environment in learning Quran memorization, namely, i) mosque, ii) Padang State University campus, and iii) beach. The results of this study can be used as evaluation material for teachers and as a determinant for choosing the right method for schools to arouse the enthusiasm of students in learning to memorize the Quran.