bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and validation of a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for the screening of high-risk pregnant women for gestational diabetes mellitus in Pakistan
Authors: Naz Sabahat , Jamal Samreen , Jaffar Ali , Azam Iqbal , Chandir Subhash , Qureshi Rahat , Babar Neelofur , Wali Aisha Syed , Iqbal Romaina 
Published: July 2024

IntroductionThe prevalence of gestational diabetes mellitus (GDM) is on the rise in low-income and middle-income countries, such as Pakistan. Therefore, the development of a risk score that is simple, affordable and easy to administer is needed. Our study aimed to develop a Non-INvaSive Pregnancy RIsk ScoRE (INSPIRE) for GDM screening in Pakistani pregnant women based on risk factors reported in the literature.MethodsUsing a cross-sectional study design, we enrolled 500 pregnant women who attended antenatal clinics at one tertiary and two secondary care hospitals in Karachi between the 28th and 32nd weeks of gestation. We randomly divided data into derivation (n=404; 80%) and validation datasets (n=96; 20%). We conducted interviews to collect information on sociodemographic factors and family history of diabetes, measured mid-upper arm circumference (MUAC) and reviewed the medical records of women for obstetric history and oral glucose tolerance test (OGTT) results. We performed a multivariable logistic regression analysis to obtain coefficients of selected predictors for GDM in the derivation dataset. Calibration was estimated using Pearson’s χ2 goodness of fit test while discrimination was checked using the area under the curve (AUC) in the validation dataset.ResultsOverall, the GDM prevalence was 26% (n=130). INSPIRE was based on six predictors: maternal age, MUAC, family history of diabetes, a history of GDM, previous bad obstetrical outcome and a history of macrosomia. INSPIRE achieved a good calibration (Pearson’s χ2=29.55, p=0.08) and acceptable discrimination with an AUC of 0.721 (95% CI 0.61 to 0.83) with a sensitivity of 74.1% and specificity of 59.4% in the validation dataset.ConclusionWe developed and validated an INSPIRE that efficiently differentiates Pakistani pregnant women at high risk of GDM from those at low risk, thus reducing the unnecessary burden of the OGTT test.
Cross-validation of the Canadian Assessment of Physical Literacy second edition (CAPL-2) for Spanish children
Authors: Mendoza Muñoz Maria , López-Gil José Francisco , Pastor-Cisneros Raquel , Castillo Paredes Antonio , Urbano Mairena Javier , Tremblay Mark , Carlos Vivas Jorge 
Published: July 2024

Background/objectiveThis study aimed to explore physical literacy (PL) using the Canadian Assessment of Physical Literacy, second edition (CAPL-2), adapt it to the Spanish context and provide evidence of its validity for use in Spanish children aged 8–12.MethodsA total of 280 students (150 girls, mean age 10.5±0.9 years) from Extremadura (Spain) completed the CAPL-2. Means and SDs were used to present CAPL-2 scores according to age and sex, as well as frequencies to place participants at different PL levels. Confirmatory factor analysis (CFA) was conducted to establish the best model fit for the data.ResultsThe median PL of Spanish children was progressing, and girls had a lower PL than boys for all ages except 12 years. The results supported a four-domain model for the CAPL-2 Spanish version and reported good fit indices after CFA (χ2per df ratio=1.118; P (χ2)=0.256; root mean square error of approximation=0.021; comparative fit index=0.987; Tuker-Lewis index=0.991; normed fit index=0.895).ConclusionThe CAPL-2 model is a valid and reliable instrument for Spanish children aged 8–12. It represents the first tool that assesses PL in Spanish children, covering the domains of motivation and confidence, physical competence, knowledge and understanding, and daily behaviour. It may be relevant for all professionals related to physical activity, education and the health field.
Burden of unintentional drowning in China from 1990 to 2019 and exposure to water: findings from the Global Burden of Disease 2019 study
Authors: Jin Ye , Ye Pengpeng , Tian Maoyi , Duan Leilei , Peden Amy E , Franklin Richard Charles 
Published: July 2024

BackgroundDrowning is an important contributor to the burden of deaths in China. Exposure to open water is a risk factor for drowning, but few studies quantify its impact on drowning. The purpose of this study was to provide an up-to-date analysis of unintentional drowning in China, including impact of exposure to open water.MethodsChinese provincial data from the Global Burden of Disease Study 2019 were used to describe the burden of unintentional drowning in 33 provinces and changes from 1990 to 2019. Provincial outdoor open water resource data were used to explore the relationship between outdoor open water resources and drowning burden using K-median clustering analysis.ResultsBetween 1990 and 2019, the unintentional drowning incidence, mortality and disability adjusted life years (DALY) rates declined by 31.2%, 68.6% and 74.9%, respectively, with differences by age, sex and province. In 2019, the DALY rate for drowning was relatively higher in children under 20 year, the elderly over 80 years than other age groups and was relatively higher in men. There was no statistical difference in overall incidence rate by sex. Provincial differences in unintentional drowning burden show a positive relationship with the availability and size of outdoor open water.ConclusionsAs expected availability of water increases drowning risk. There is a need to address drowning environmental risk especially among children and the elderly. Localised water safety plans which consider drowning burden and environmental risk factors are needed in China to ensure a sustained decline of unintentional drowning.
Interventions that address interpersonal violence experienced by adolescents globally: a systematic review of reviews
Authors: Walker Natasha , Peden Amy E , Bestman Amy , Baffsky Rachel , Willoughby Melissa , Ma Tracey , Moeller Holger , Torok Michelle , Peden Margaret , Ivers Rebecca Q , Cullen Patricia 
Published: July 2024

Globally, adolescents experience a significant burden of interpersonal violence, impacting their health, well-being and life trajectory. To address this, decision-makers need reliable evidence on effective interventions across various contexts.ObjectivesSynthesise the evidence for interventions addressing interpersonal violence experienced by adolescents aged 10–25 years.MethodsSix electronic databases were systematically searched. Systematic reviews and meta-analyses published globally between 2010 and 2022 were included if they reported interventions addressing interpersonal violence experienced by adolescents. Results were synthesised narratively.Results35 systematic reviews were included, of which 16 were also meta-analyses. Majority of reviews included interventions set in high income countries (71%) and implemented in educational settings (91%). Effectiveness was reported in majority of interventions measuring victimisation and/or perpetration of intimate partner violence, sexual violence, bullying and/or cyberbullying (90%), majority of interventions measuring improvements in knowledge and attitudes towards violence (94%) and all interventions measuring bystander behaviour and improvements in well-being and quality of life. However, the quality of included reviews as per Assessment of Multiple Systematic Reviews 2 and National Health and Medical Research Council was low, and equity as per PROGRESS-PLUS was seldom considered. There was also a paucity of interventions addressing interpersonal violence in low-middle income countries (12%) and none of the included interventions specifically addressed interpersonal violence perpetrated in the home such as family violence.ConclusionThere is some evidence of promising interventions to address interpersonal violence experienced by adolescents, however there are gaps in scope and implementation. There is a need for equity-oriented public health approaches to comprehensively address the disproportionate burden of interpersonal violence experienced by adolescents globally, including those at the highest risk of harm.PROSPERO registration numberCRD42020218969.
Intergenerational transmission of health inequalities: research agenda for a life course approach to socioeconomic inequalities in health
Authors: Houweling Tanja A J , Grünberger Ilona 
Published: July 2024

Explanations for socioeconomic inequalities in adult health are usually sought in behaviours and environments in adulthood. Yet, there is compelling evidence that the first two decades of life contribute substantially to both adult socioeconomic position (SEP) and adult health. This has implications for explanatory health inequalities research.We propose an analytical framework to advance research on the intergenerational transmission of health inequalities, that is, on intergenerational transmission of socioeconomic and associated health (dis)advantages at the family level, and its contribution to health inequalities at the population level. The framework distinguishes three transmission pathways: (1) intergenerational transmission of SEP, with effects on offspring health fully mediated by offspring SEP; (2) intergenerational transmission of health problems affecting SEP and (3) intergenerational transmission of both SEP and health, without a causal relationship between offspring adult SEP and health. We describe areas for future research along this framework and discuss the challenges and opportunities to advance this field.
Plasma metabolomics of immune-related adverse events for patients with lung cancer treated with PD-1/PD-L1 inhibitors
Authors: Chen Juan , Liu Jia-Si , Liu Jun-Yan , She Lei , Zou Ting , Yang Fan , Li Xiang-Ping , Wang Zhan , Liu Zhaoqian 
Published: July 2024

BackgroundMetabolomics has the characteristics of terminal effects and reflects the physiological state of biological diseases more directly. Several current biomarkers of multiple omics were revealed to be associated with immune-related adverse events (irAEs) occurrence. However, there is a lack of reliable metabolic biomarkers to predict irAEs. This study aims to explore the potential metabolic biomarkers to predict risk of irAEs and to investigate the association of plasma metabolites level with survival in patients with lung cancer receiving PD-1/PD-L1 inhibitor treatment.MethodsThe study collected 170 plasmas of 85 patients with lung cancer who received immune checkpoint inhibitors (ICIs) treatment. 58 plasma samples of 29 patients with irAEs were collected before ICIs treatment and at the onset of irAEs. 112 plasma samples of 56 patients who did not develop irAEs were collected before ICIs treatment and plasma matched by treatment cycles to onset of irAEs patients. Untargeted metabolomics analysis was used to identify the differential metabolites before initiating ICIs treatment and during the process that development of irAEs. Kaplan-Meier curves analysis was used to detect the associations of plasma metabolites level with survival of patients with lung cancer.ResultsA total of 24 differential metabolites were identified to predict the occurrence of irAEs. Baseline acylcarnitines and steroids levels are significantly higher in patients with irAEs, and the model of eight acylcarnitine and six steroid metabolites baseline level predicts irAEs occurrence with area under the curve of 0.91. Patients with lower concentration of baseline decenoylcarnitine(AcCa(10:1) 2, decenoylcarnitine(AcCa(10:1) 3 and hexanoylcarnitine(AcCa(6:0) in plasma would have better overall survival (OS). Moreover, 52 differential metabolites were identified related to irAEs during ICIs treatment, dehydroepiandrosterone sulfate, corticoserone, cortisol, thyroxine and sphinganine 1-phaosphate were significantly decreased in irAEs group while oxoglutaric acid and taurocholic acid were significantly increased in irAEs group.ConclusionsHigh levels of acylcarnitines and steroid hormone metabolites might be risk factor to development of irAEs, and levels of decenoylcarnitine (AcCa(10:1) 2, decenoylcarnitine (AcCa(10:1) 3 and hexanoylcarnitine (AcCa(6:0) could be used to predict OS for patients with lung cancer received ICIs treatment.
Testing strong gravitational lensing effects of various supermassive compact objects for the static and spherically symmetric hairy black hole by gravitational decoupling
Authors: Mustafa G. , Maurya S. K. 
Published: July 2024

AbstractWe investigate the strong gravitational lensing effects of various supermassive compact objects for the static and spherically symmetric hairy black hole by gravitational decoupling. To do this purpose, we first numerically calculate the strong deflection limit coefficients and strong deflection angle with the decoupling modified black hole parameter$$\alpha $$αand$$\beta $$β. It is observed that for the lowest value of the parameter$$\alpha $$α, the strong deflection angle$$\alpha _D$$αDreaches its maximum value with the parameter$$\beta $$βand for the lowest value of the parameter$$\beta $$β, strong deflection angle$$\alpha _D$$αDreaches its minimum value with the parameter$$\alpha $$α; and also the strong deflection angle for$$\alpha _D$$αDfor the decoupling modified black hole is smaller than standard Schwarzschild black hole$$(\alpha =0)$$(α=0). We investigate the various astrophysical consequences via strong gravitational lensing by considering the example of various supermassive BHs in the centre nearby galaxies and observe that the decoupling modified black hole could be quantitatively distinguished from the standard Schwarzschild black hole ($$\alpha =0$$α=0). Findings in our observation suggest that the observational test for a decoupling-modified black hole is indeed feasible.
A comprehensive data-driven odyssey to explore the equation of state of dark energy
Authors: Dinda Bikash R. , Banerjee Narayan 
Published: July 2024

AbstractFor the first time, we reconstruct the dark energy equation of the state parameter w from the combination of background and perturbation observations, specifically combining the Hubble parameter data from cosmic chronometer observations and the logarithmic growth rate data from the growth rate observations. We do this analysis using posterior Gaussian process regression without considering any specific cosmological model or parametrization. However there are three main assumptions: (I) a flat Friedmann–Lemaître–Robertson–Walker (FLRW) metric is considered for the cosmological background, (II) there is no interaction between dark energy and matter sectors, and (III) for the growth of inhomogeneity, sub-Hubble approximation and linear perturbations are considered. This study is unique in the sense that the reconstruction of w is independent of any derived parameters such as the present values of the matter-energy density parameter and Hubble parameter. From the reconstruction, we look at how the dark energy equation of state evolves between redshifts 0 and 1.5, finding a slight hint of dynamical behavior in dark energy. However, the evidence is not significant. We also find a leaning towards non-phantom behavior over phantom behavior. We observe that the $$\varLambda $$
Λ
CDM model $$(w=-1)$$

(
w
=
-
1
)

nearly touches the lower boundary of the 1$$\sigma $$
σ
confidence region in the redshift range $$0.6 \lesssim z \lesssim 0.85.$$

0.6
≲
z
≲
0.85
.

However, it comfortably resides within the 2$$\sigma $$
σ
confidence region in the whole redshift range under investigation, $$0\le z \le 1.5.$$

0
≤
z
≤
1.5
.

Consequently, the non-parametric, model-independent reconstruction of dark energy provides no compelling evidence to deviate from the $$\varLambda $$
Λ
CDM model when considering cosmic chronometer and growth rate observations.
RNF149 Destabilizes IFNGR1 in Macrophages to Favor Postinfarction Cardiac Repair
Authors: Huang Chun-Kai , Chen Zhiyong , Zhou Zhongxing , Chen Shuaijie , Chen Longqing , Li Liliang , Li Tao , Yan Xiaoxiang , Chai Dajun 
Published: July 2024

BACKGROUND:
Macrophage-driven inflammation critically involves in cardiac injury and repair following myocardial infarction (MI). However, the intrinsic mechanisms that halt the immune response of macrophages, which is critical to preserve homeostasis and effective infarct repair, remain to be fully defined. Here, we aimed to determine the ubiquitination-mediated regulatory effects on averting exaggerated inflammatory responses in cardiac macrophages.

METHODS:
We used transcriptome analysis of mouse cardiac macrophages and bone marrow–derived macrophages to identify the E3 ubiquitin ligase RNF149 (ring finger protein 149) as a modulator of macrophage response to MI. Employing loss-of-function methodologies, bone marrow transplantation approaches, and adenovirus-mediated RNF149 overexpression in macrophages, we elucidated the functional role of RNF149 in MI. We explored the underlying mechanisms through flow cytometry, transcriptome analysis, immunoprecipitation/mass spectrometry analysis, and functional experiments. RNF149 expression was measured in the cardiac tissues of patients with acute MI and healthy controls.

RESULTS:

RNF149 was highly expressed in murine and human cardiac macrophages at the early phase of MI. Knockout of RNF149, transplantation of
Rnf149
–/–
bone marrow, and bone marrow macrophage–specific RNF149-knockdown markedly exacerbated cardiac dysfunction in murine MI models. Conversely, overexpression of RNF149 in macrophages attenuated the ischemia-induced decline in cardiac contractile function. RNF149 deletion increased infiltration of proinflammatory monocytes/macrophages, accompanied by a hastened decline in reparative subsets, leading to aggravation of myocardial apoptosis and impairment of infarct healing. Our data revealed that RNF149 in infiltrated macrophages restricted inflammation by promoting ubiquitylation-dependent proteasomal degradation of IFNGR1 (interferon gamma receptor 1). Loss of IFNGR1 rescued deleterious effects of RNF149 deficiency on MI. We further demonstrated that STAT1 (signal transducer and activator of transcription 1) activation induced
Rnf149
transcription, which, in turn, destabilized the IFNGR1 protein to counteract type-II IFN (interferon) signaling, creating a feedback control mechanism to fine-tune macrophage-driven inflammation.

CONCLUSIONS:
These findings highlight the significance of RNF149 as a molecular brake on macrophage response to MI and uncover a macrophage-intrinsic posttranslational mechanism essential for maintaining immune homeostasis and facilitating cardiac repair following MI.
Vaccine Therapy for Heart Failure Targeting the Inflammatory Cytokine Igfbp7
Authors: Katoh Manami , Nomura Seitaro , Yamada Shintaro , Ito Masamichi , Hayashi Hiroki , Katagiri Mikako , Heryed Tuolisi , Fujiwara Takayuki , Takeda Norifumi , Nishida Miyuki , Sugaya Maki , Kato Miki , Osawa Tsuyoshi , Abe Hiroyuki , Sakurai Yoshitaka , Ko Toshiyuki , Fujita Kanna , Zhang Bo , Hatsuse Satoshi , Yamada Takanobu , Inoue Shunsuke , Dai Zhehao , Kubota Masayuki , Sawami Kousuke , Ono Minoru , Morita Hiroyuki , Kubota Yoshiaki , Mizuno Seiya , Takahashi Satoru , Nakanishi Makoto , Ushiku Tetsuo , Nakagami Hironori , Aburatani Hiroyuki , Komuro Issei 
Published: July 2024

BACKGROUND:
The heart comprises many types of cells such as cardiomyocytes, endothelial cells (ECs), fibroblasts, smooth muscle cells, pericytes, and blood cells. Every cell type responds to various stressors (eg, hemodynamic overload and ischemia) and changes its properties and interrelationships among cells. To date, heart failure research has focused mainly on cardiomyocytes; however, other types of cells and their cell-to-cell interactions might also be important in the pathogenesis of heart failure.

METHODS:
Pressure overload was imposed on mice by transverse aortic constriction and the vascular structure of the heart was examined using a tissue transparency technique. Functional and molecular analyses including single-cell RNA sequencing were performed on the hearts of wild-type mice and EC-specific gene knockout mice. Metabolites in heart tissue were measured by capillary electrophoresis-time of flight-mass spectrometry system. The vaccine was prepared by conjugating the synthesized epitope peptides with keyhole limpet hemocyanin and administered to mice with aluminum hydroxide as an adjuvant. Tissue samples from heart failure patients were used for single-nucleus RNA sequencing to examine gene expression in ECs and perform pathway analysis in cardiomyocytes.

RESULTS:

Pressure overload induced the development of intricately entwined blood vessels in murine hearts, leading to the accumulation of replication stress and DNA damage in cardiac ECs. Inhibition of cell proliferation by a cyclin-dependent kinase inhibitor reduced DNA damage in ECs and ameliorated transverse aortic constriction–induced cardiac dysfunction. Single-cell RNA sequencing analysis revealed upregulation of
Igfbp7
(insulin-like growth factor-binding protein 7) expression in the senescent ECs and downregulation of insulin signaling and oxidative phosphorylation in cardiomyocytes of murine and human failing hearts. Overexpression of
Igfbp7
in the murine heart using AAV9 (adeno-associated virus serotype 9) exacerbated cardiac dysfunction, while EC-specific deletion of
Igfbp7
and the vaccine targeting Igfbp7 ameliorated cardiac dysfunction with increased oxidative phosphorylation in cardiomyocytes under pressure overload.

CONCLUSIONS:
Igfbp7 produced by senescent ECs causes cardiac dysfunction and vaccine therapy targeting Igfbp7 may be useful to prevent the development of heart failure.