bluuebunny/crossref_metadata_2025_split huggingface dataset:
Immunohistochemistry in pre-invasive vulvar lesions: observations, concerns and an algorithmic approach
Authors: Dunaevskaya V. , Med V. , Krotevych M. 
Published: July 2024

The aim of the study was to investigate the presence of immunohistochemical markers p16, p53 and Ki67 and their diagnostic and prognostic value in women with pre-invasive vulvar lesions such as vulvar high-grade squamous intraepithelial lesions (VHSIL) and differentiated vulvar intraepithelial neoplasia (dVIN). Materials and methods. The results of immunohistochemical (IHC) examination of samples obtained from 253 women diagnosed with HSIL or dVIN who asked for medical care at the National Cancer Institute (Kyiv, Ukraine) in 2017-2023 were analysed. 155 of all women examined were diagnosed with dVIN and 98 with VHSIL. All patients underwent a vulvar biopsy. Histological typing of biopsy samples was performed using routine haematoxylin and eosin staining and immunohistochemical (IHC) examination. The IHC study was performed using monoclonal mouse antibody p16 (Monoclonal Mouse Antibody p16 (Mob575-01)) using the Thermo scientific PA1-16662 system, monoclonal mouse antibody Ki-67 (Monoclonal Mouse Anti-Human Ki-67 Antigen Clone MIB-1 (Dako IR-626)) and monoclonal mouse antibody p53 (Monoclonal Mouse Anti-Human p53 Protein Clone DO-7 (Dako IS-616)) using the EnVisionTM FLEX detection system (Dako, Denmark). Results.The average age of patients with dVIN was 58.26±10.17 years old, and the average age of patients with VHSIL was 39.65±10.22 years old. According to the results of the study, all patients with VHSIL (n=98) had positive staining for Ki67 in the middle and upper epithelial sections, and only 72% (n=71) - for p16. Staining for p53 was negative in all cases. That is, 28% (n=27) of the patients with VHSIL were negative for p16 and positive for Ki67. p53 staining showed the presence of a "wild-type" variant in 65 patients with dVIN (42%) and a "mutant" variant in 90 women (58%). None of the patients showed positive staining for p16. As for VHSIL, the Ki67 marker was detected in 100% of cases and in all situations in the middle and upper parts of the epithelium, while with dVIN patients, such staining was observed in only 45 women (29%). Conclusions. The determination of IHC markers p16, p53 and Ki67 allows to distinguish dVIN from VHSIL, especially in difficult diagnostic cases. In addition, the presence of mutant p53 indicates the possibility of rapid progression to cancer and requires immediate and more aggressive treatment and follow-up.
An update on e-cigarettes and orthodontics
Authors: Bell Joseph , Jackson Joshua , McGuckin Bronagh , Holliday Richard 
Published: July 2024

E-cigarettes can be a useful cessation aid for adult smokers. However, the use of e-cigarettes by young people in the UK has been on the rise and is of increasing concern. The implications of e-cigarette use among patients undergoing orthodontic treatment have not yet been reviewed. This narrative review explores the emerging evidence base underpinning the relationship of e-cigarette use on tooth movement, demineralization and surgical outcomes. CPD/Clinical Relevance: The use of e-cigarettes has rapidly increased, and it is important to understand the possible implications for orthodontic treatment.
Risk factors of mortality in septicemic extramural neonates: an experience from resource limited setting of central India
Authors: Meshram Rajkumar Motiram , Kadu Kalyani S 
Published: July 2024

Background: Sepsis is responsible for 30-40% neonatal deaths which can be attributed to various maternal, neonatal and sociocultural risk factors. Objective: To recognize the clinical and laboratory risk factors of mortality in extramural neonatal sepsis. Material and methods: Prospective observational study was conducted for duration of one year on extramural neonates with suspected sepsis. Maternal, neonatal and sociocultural factors were analyzed. Results: Average duration of hospital stay was shorter in non-survival compared to survival neonates (p=0.01). On univariate analysis preterm (p<0.001), weight<2500gms (p=0.01), home delivery (p=0.004) by Traditional Birth Attendant (p=0.003) , unbooked mother (p=0.03), peripartum febrile illness (p=0.02) and Premature rupture of membrane > 18 hours were the significant risk factors of mortality. Those neonates admitted with lethargy (p=0.04), hypothermia (p=0.01), respiratory distress (p<0.001), convulsion (p<0.0001), Jaundice (p=0.006), Apgar score <5at 1minute (p=0.01) , prolonged CFT (P<0.001), previously hospitalized (p<0.001) ,required mechanical ventilation (p=0.01),had thrombocytopenia (p=0.02), positive CRP (P<0.001), hypoglycemia (p=0.04), oxygen saturation ?90% (p=0.04), abnormal CSF/chest radiograph finding (p=0.002) had significantly higher mortality. Delivery conducted by traditional birth attendant, neonates travelled more than 80km, prematurity, bottle feed, h/o previous hospitalization, h/o lethargy, hypothermia, convulsions, prolonged CFT and isolation of micro-organisim were the independent risk factors of mortality in extramural neonates with sepsis Conclusion: Delivery conducted by traditional birth attendant, neonates travelled more than 80km, prematurity, bottle feed, h/o previous hospitalization, h/o lethargy, hypothermia, convulsions, prolonged CFT and isolation of micro-organisim were the independent risk factors of mortality in extramural neonates with sepsis.
PSYCHOLOGICAL WELL BEING OF EMERGING ADULTS IN RELATION TO THEIR PARENTS DURING PANDEMIC COVID-19
Authors: Dinardinata Adi , Fatmasari Agustin Erna , Indrawati Endang Sri 
Published: July 2024

Relations with parents have a lot of influence because emerging adults with student status are spending more time at home during pandemic. This study aims to describe the psychological well-being of emerging adults during the Covid-19 pandemic. The research method used is a phenomenological qualitative approach with InterpretativePhenomenological Analysis. Data were obtained through in-depth interviews, involving six respondents consisting of 3 girls and 3 boys selected by purposive sampling technique. The inclusive criteria are emerging adults, live at home with their parents during the pandemic, and willing to become respondents. The result were six themes related to psychological well-being, namely feelings during a pandemic, difficulties experienced,solutions to overcome them, relationships with parents, support provided by parents, and hopes related to a pandemic situation. An interesting finding in this study is that respondents who have positive or negative relationships with their parents will still be able to achieve psychological well-being. The difference is that the process of respondents with negative relationships is more difficult than respondents with positive relationships.Emerging adults must be able to find the meaning of life so that in difficult situations they can still be independent and adapt well.
Analisis Unsur Budaya Dalam Tradisi Sabumi Babarit di Desa Citangtu Kecamatan Kuningan Kabupaten Kuningan
Authors: Julianti Delia , Nuraeni Leni 
Published: July 2024

Indonesia has various cultures and traditions that are still maintained. From these various traditions, there are different elements and values, each of which has unique characteristics. This cultural diversity is found in various corners of Indonesia, such as what can be found in the eastern part of West Java, namely in Kuningan Regency. Kuningan has various traditions, cultures and customs that are still maintained. You can find a tradition that is still routinely carried out in Kuningan Regency, specifically in Citangtu Village, namely Talahab Hamlet, where the Sabumi Babarit tradition is still carried out. This article aims to find out the reasons why this tradition is still carried out and what cultural elements are included in this tradition. This study uses a qualitative approach and research on this cultural element uses Koetjaraningrat theory. The results obtained from this research are that there are 4 processions carrying out the sabumi babarit tradition, namely; 1) Hajat kekah, 2) Sura porridge, 3) Sabumi babarit, 4) Golewang. It is hoped that the results obtained will be useful for all readers.This is a description of the research that contains the formulation of the problem, objectives, methods, theoretical and literature reviews, and general results. If using Indonesian language, it must be adjusted to the latest Indonesian language rules and spelling. Composed in 150-200 words. Using Times New Roman font, 11pt size, 1 space, and italicized. Keywords: sabumi babarit, traditions, cultural elements
Cultural Acculturation and Sexual Education Reflections of Ketupat Jembut in Tegalsari City Semarang
Authors: Mukafi Muhammad Hamdan , Gwyneth Velodyne Abigail Clarence 
Published: July 2024

It is common to hear the word Ketupat, especially when celebrating Eid al-Fitir after a month of fasting during Ramadan. In the Javanese Islamic tradition, Ketupat is often interpreted as a symbol of acknowledging mistakes and asking for forgiveness. Related to this, the people of Semarang City, especially the Tegalsari area, expanded the meaning of the Ketupat by giving birth to Ketupat Jembut. Looking at the name, previous studies on Ketupat that interpret it as a sacred and holy tradition also require further understanding, especially in finding the relationship between the sacred context and the taboo and vulgar in people's views. However, this study looks at how Muslim communities in various regions perform cultural acculturation and allow a positive view of it. By conducting interviews and direct observations of the Tegalsari community, this research found several positive perspectives on the birth and running of the Ketupat Jembut tradition. The meaning of these observations relates elements of myth, arbitrary, and epistemes that arise from something vulgar, but are related to the context of sexual education and sufism. The normalization of the word jembut leads to peace of heart and purity of soul as explained about the function of sufism in sexual education. Moreover, the finding of the name Ketupat jembut also intersects with the understanding of the honor of sexuality for women as subjects and men as participants. Keywords: Ketupat jembut,myths, arbitrary, epistemes, tasawuf, sexual education
Interprofessional clinical reasoning education
Authors: Eriksen Thomas , Gögenur Ismaïl 
Published: July 2024

Abstract
Clinical reasoning is considered one of the most important competencies but is not included in most healthcare curricula. The number and diversity of patient encounters are the decisive factors in the development of clinical reasoning competence. Physical real patient encounters are considered optimal, but virtual patient cases also promote clinical reasoning. A high-volume, low-fidelity virtual patient library thus can support clinical reasoning training in a safe environment and can be tailored to the needs of learners from different health care professions. It may also stimulate interprofessional understanding and team shared decisions. Implementation will be challenged by tradition, the lack of educator competence and prior experience as well as the high-density curricula at medical and veterinary schools and will need explicit address from curriculum managers and education leads.
Transformers meets neoantigen detection: a systematic literature review
Authors: Machaca Vicente , Goyzueta Valeria , Cruz María Graciel , Sejje Erika , Pilco Luz Marina , López Julio , Túpac Yván 
Published: July 2024

Abstract
Cancer immunology offers a new alternative to traditional cancer treatments, such as radiotherapy and chemotherapy. One notable alternative is the development of personalized vaccines based on cancer neoantigens. Moreover, Transformers are considered a revolutionary development in artificial intelligence with a significant impact on natural language processing (NLP) tasks and have been utilized in proteomics studies in recent years. In this context, we conducted a systematic literature review to investigate how Transformers are applied in each stage of the neoantigen detection process. Additionally, we mapped current pipelines and examined the results of clinical trials involving cancer vaccines.
Assessing osteoporosis screening compliance in total joint surgery: a retrospective chart review
Authors: Shepard Samuel , Bartholomew Ania , Houserman David , Bamberger H. Brent , Manocchio Antonio G. 
Published: July 2024

Abstract

Context
Osteoporosis is a prevalent concern, particularly among aging populations, leading to increased risk of fractures, including those related to hip and knee arthroplasty procedures. Screening for osteoporosis, especially with dual X-ray absorptiometry (DXA) scans, is crucial for early detection and management.

Objectives
This study aimed to assess adherence to osteoporosis screening guidelines among patients aged 65 and older undergoing elective total hip arthroplasty (THA) or total knee arthroplasty (TKA) within a single health network. Factors influencing screening adherence were also explored.

Methods
A retrospective chart review of 2,160 patients undergoing elective THA or TKA between January 2019 and January 2023 was conducted. Demographic data, osteoporosis screening status, and occurrence of periprosthetic fractures were analyzed. Statistical analysis included descriptive statistics and chi-square tests.

Results
Only 24.1 % of eligible patients underwent a DXA scan prior to surgery. Females were more likely to undergo screening than males, and race was also associated with screening status. A total of 45 periprosthetic fractures were identified, with no significant correlation between osteoporosis status, DXA screening, and fracture occurrence.

Conclusions
Adherence to osteoporosis screening guidelines among geriatric patients undergoing elective total joint arthroplasty remains low within the studied health network. Despite the lack of correlation between screening and fracture occurrence in this study, the importance of screening and potential optimization in high-risk patients is emphasized. Further research is needed to assess outcomes associated with different care pathways in bone health screening and management for elective geriatric total joint patients.
Effect of graphene oxide on the properties of ternary limestone clay cement paste
Authors: Gong Jing , Qian Yi , Xu Ziyang , Chen Chaoqian , Jin Yijing , Zhang Junze , Li Zhipeng , Shi Xianming 
Published: July 2024

Abstract
Given the pressing threat of global warming, it is imperative to promote CO2 emission reduction within the cement industry which is widely recognized as a major contributor to the overall carbon footprint. Limestone clay cement (LCC) emerges as a promising alternative to Portland cement. However, to facilitate the implementation of LCC technology, it is urgent to address the low early-age compressive strength issue. Inspired by the successful implementation of nano-engineered cementitious material, we hereby introduce a novel nanomaterial, graphene oxide (GO), into unconventional LCC paste (cement:clay:limestone = 65%:20%:15%, water/binder ratio: 0.45). Experimental results revealed that the 0.09% GO by weight of the LCC binder was the optimal dosage in this work, which improved the compressive strength of the LCC paste at 7, 14, and 28 days by 25.6, 21.6, and 20.3%, respectively. Advanced characterizations were then conducted, suggesting that the admixed GO not only enabled a higher polymerization degree of binder hydrates (which benefited the development of compressive strengths) but also improved the carbonation resistance of LCC paste. These findings not only offer valuable insights for researchers but also provide practical guidance for engineers in the field. Notably, the admixed GO converted the unstable orthorhombic crystal systemic aragonite to the stable trigonal crystal systemic calcite, which offers insights into the technology of carbon sequestration in concrete.
How Can Philosophy Improve Your Sense of Humor?
Authors: Amir Lydia 
Published: July 2024

Abstract
It is often said that humor is a powerful tool that is helpful for living a good life. When saying this, we assume that humor is used sporadically for chance encounters with the spontaneously funny. In what follows, however, I lay out the educational premises of a new worldview, which, by making systematic use of self-referential humor in order to handle events that are not immediately funny, leads to a stable state which philosophers call the good life. The multifaceted philosophic notion of the “good life” will be reduced to the principles proposed below; but humor as presented here can help achieve any philosophical ideal, even one that is not in the spirit of the view articulated here.
However, the form of philosophic humor that I advance in this article requires education, mainly self-education, as is often the case with much successful education. Thus, as intimated by existential philosophers, I maintain, first, that laughter can and should be learned; and second, that the discipline of laughter is philosophically significant because laughter enables to endorse new norms and to change one’s attitude towards oneself, others, and the world. To achieve the educational aims of this article, the theoretical clarification of the worldview that I introduce, Homo risibilis or the ridiculous human being, is illustrated by exercises that help implementing it.
Cross-linguistic insights in the theory of semantics and its interface with syntax
Authors: Szabolcsi Anna 
Published: July 2024

Abstract
This paper highlights a small selection of cases where cross-linguistic insights have been important to big questions in the theory of semantics and the syntax/semantics interface. The selection includes (i) the role and representation of Speaker and Addressee in the grammar; (ii) mismatches between form and interpretation motivating high-placed silent operators for functional elements; and (iii) the explanation of semantic universals, including universals pertaining to inventories, in terms of learnability and the trade-off between informativeness and simplicity.
A INCORPORAÇÃO DA DIMENSÃO AMBIENTAL DA SUSTENTABILIDADE NO CONTEXTO DA GESTÃO DE RECURSOS HUMANOS
Authors: Rosa Alexsandra Matilde Resende , Brasil Deilton Ribeiro 
Published: July 2024

Resumo: O presente artigo pretende contribuir com as discussões acerca da necessidade de uma crescente conscientização da sociedade no que tange à importância de minimizar os efeitos negativos da atividade humana no meio ambiente. O objetivo desta pesquisa é demonstrar a relevante função do setor de recursos humanos na incorporação da dimensão ambiental pelas empresas e a integração entre essa área e a de gestão ambiental nas organizações, com foco em uma produção baseada em atividades sustentáveis. O procedimento escolhido foi o de revisão bibliográfica e documental e o método empregado foi o dedutivo. Como resultado das discussões empreendidas no trabalho, concluiu-se que, para garantir a conscientização e a mudança de comportamento das empresas, o setor de recursos humanos tem um papel de destaque e deve se aproximar da área de gestão ambiental para que as empresas alcancem a eficiência na utilização dos recursos naturais e na defesa do meio ambiente. Palavras-chave: Empresas; Gestão de recursos humanos; Gestão ambiental; Defesa do meio ambiente; Sustentabilidade. Abstract: This paper aims to analyze the need for a growing awareness in our society of the importance of minimizing the negative effects of human activity on the environment. The objective of this research is to highlight the relevant role of the human resources sector in the incorporation of the environmental dimension by companies and the integration between two areas that focus on production based on sustainable activities. The chosen procedure was the bibliographic and documentary review and the method used was the deductive one. The results achieved call to the conclusion that to ensure awareness and change of behavior of the companies, the human resources sector has a prominent role and should approach to the environment management area to make the companies efficient and rational in the use of natural resources as a consequence of environmental protection. Keywords: Companies; Human and Environmental management; Sustainability. Sumário: Introdução. 1. Sistema econômico, as empresas e o meio ambiente. 2. O papel da gestão de recursos humanos e da gestão ambiental. 3. Integração entre gestão ambiental e gestão de recursos humanos. Considerações finais. Referências.
Concrete's fire resistance improvement with waste glass and ceramic aggregates
Authors: Al-jamaily Naghm Mahdi Saidik , Atiea Huda M. , Jabal Qusay A. , Mahdi Waseem H. , Alasadi Laith Abdulrasool 
Published: July 2024

AbstractEven though concrete structures are safer than steel structures in terms of fire resistance, the risk exists in concrete structures by spalling or exploding, especially in high-strength concrete. This study aims to produce a particular type of concrete using waste ceramics as fine aggregate and waste glass as coarse aggregate and compare data with normal aggregate concrete. Studies show that using waste ceramic and glass increases the fire resistance of concrete. After fire exposure in the control mix, the residual compressive strength was 10 MPa. The waste aggregate concrete was found to be 26.9 MPa after 800 centigrade exposures, which was an excellent result. Waste materials decreased construction costs and led to a clean environment.
UM OLHAR INCLUSIVO SOBRE OS DIREITOS E GARANTIAS DAS PESSOAS NEURODIVERGENTES E NEUROATÍPICAS
Authors: Xavier de Souza José Rafael , Tavares Thiago Passos , Fontes Mota Marlton 
Published: July 2024

Os direitos e as garantias de inclusão das pessoas com transtornos do espectro autista (TEA) e transtornos do déficit de atenção e hiperatividade (TDAH) foram progressivamente acentuados nas últimas décadas, seguindo a perspectiva humanizada da Constituição Federal de 1988. Ao estabelecer que a pessoa com transtorno do espectro autista é considerada pessoa com deficiência, para todos os efeitos legais, a Lei nº 12.764/2012 estabelece um marco diferenciador no quesito inclusão social e humanização, ampliando as garantias protetivas. A pesquisa foi delimitada a partir da seguinte problemática: como a legislação brasileira concebe garantias protetivas às pessoas com transtornos do espectro autista (TEA) e o transtorno de déficit de atenção (TDAH) para assegurar os direitos desses indivíduos, sob a égide da Carta Constitucional de 1988? Foram estabelecidos como objetivo geral, compreender os elementos psicossociais e jurídicos que consolidam a proteção às pessoas neurodivergentes e neuroatípicas, e para os objetivos específicos: conceituar as terminologias intrínsecas à neurodivergência e à neuroatipicidade; analisar os institutos legais direcionados às pessoas com deficiência e identificar o alcance proposto pelas legislações específicas, inclusive para consignar o exercício constante de uma educação inclusiva. Os resultados comprovam, de forma conclusiva, a necessidade de um maior envolvimento da sociedade no objetivo de tornar inclusiva a atenção às pessoas neurodivergentes e neuroatípicas.