bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hemodynamic effects of dexmedetomidine during intra-operative electrocorticography for epilepsy surgery
Authors: Chaitanya G. , Arivazhagan A. , Sinha Sanjib , Reddy K. R. Madhusudan , Thennarasu K. , Bharath R. D. , Rao M. Bhaskara , Chandramouli B. A. , Satishchandra P. 
Published: November 2014

ABSTRACT
Background: Dexmedetomidine, a predominant alpha-2-adrenergic agonist has been used in anesthetic practice to provide good sedation. The drug is being recently used in neuroanesthesia during awake surgery for brain tumors and in functional neurosurgery. Materials and Methods: This prospective study analyzed the hemodynamic effects of dexmedetomidine infusion during electrocorticography in patients undergoing surgery for mesial temporal sclerosis. Dexmedetomidine infusion was administered during intra-operative electrocorticography recording, 15 minutes after the end tidal MAC of N 2 O and isoflurane were decreased to zero. Anesthesia was maintained with O 2 :air mixture = 50:50, vecuronium and fentanyl. Heart rate (HR), mean arterial pressure (MAP) and end tidal carbon dioxide (ETCO 2) were recorded across at induction, 2 min prior to dexmedetomidine (PreDEX), 5 min during dexmedetomidine infusion (DEX; 1 μg/kg), 5 min after stopping dexmedetomidine and 10 minutes after stopping dexmedetomidine. Results: Forty patients with mesial temporal sclerosis (M: F = 27:13, mean age = 28.15 ± 10.9 years; duration of epilepsy = 12.0 ± 7.9 years) underwent anterior temporal lobe resection with amygdalohippocampectomy for drug-resistant epilepsy. Infusion of dexmedetomidine caused a transient fall in HR in 87.5% of patients and an increase in MAP in 62.5% of patients, which showed a tendency to revert back towards PreDEX values within 10 min after stopping the infusion. Sixty-five percent of the patients showed ≤25% reduction and 10% of them showed >25% reduction in HR. 47.5% of the patients showed ≤25% increase and 15% of them showed >25% increase in MAP. These changes were over a narrow range and within physiological limits. Conclusion: The infusion of dexmedetomidine for a short period causes reduction of HR and increase in MAP in patients, however the variations are within acceptable range.
Study of psychiatric comorbidity in patients with headache using a short structured clinical interview in a rural neurology clinic in Western India
Authors: Desai Soaham Dilip , Pandya Radhika Himanshu 
Published: November 2014

ABSTRACT
Background: Psychiatric disorders are common in patients attending neurology clinics with headache. Evaluation of psychiatric comorbidity in patients with headache is often missed in the busy neurology clinics. Aims: To assess the prevalence of Axis-I DSM-IV psychiatric disorders in patients with primary headache disorders in a rural-based tertiary neurology clinic in Western India. Settings and Design: A cross-sectional observation survey was conducting assessing all patients with migraine, tension-type headache and chronic daily headache attending the Neurology Clinic of Shree Krishna Hospital, a rural medical teaching hospital in Karamsad, in Gujarat in Western India. Materials and Methods: A total of 101 consecutive consenting adults with headache were interviewed using Mini International Neuropsychiatric Interview (M.I.N.I.), a structured diagnostic clinical interview to assess prevalence of Axis-I DSM-IV psychiatric disorders. Statistical Analysis: Descriptive statistics were calculated using SPSS software version 16 and a binomial regression model was used to study the relationship of psychiatric co-morbidity with patient-related factors. Results: 49 out of 101 (48.5%) patients with headache suffered from depressive disorders (dysthymia or depression or suicidality), 18 out of 101 patients with headache (17.90%) suffered from anxiety related disorders (generalized anxiety disorder or agoraphobia or social phobia or panic disorder). Conclusions: Axis-I psychiatric disorders are a significant comorbidity among patients with headache disorders. M.I.N.I. can be used as a short, less time consuming instrument to assess all patients with headache disorders.
Demography, types, outcome and relationship of surgically treated intracranial suppuration complicating chronic suppurative otitis media and bacterial rhinosinusitis
Authors: Idowu Olufemi Emmanuel , Adekoya Vincent A. , Adeyinka Adesegun P. , Beredugo-Amadasun Bogofanyo K. , Olubi Olawale O. 
Published: November 2014

ABSTRACT
Introduction: Surgically treated intracranial suppurations (ICS) are uncommon, life-threatening neurosurgical emergencies. They can result from complication of chronic suppurative otitis media (CSOM) and bacterial rhinosinusitis (BRS). The objective of this study was to know the frequency of BRS and CSOM and relate it to its rare complication of surgically treated ICS while also describing the demography, type and outcome of ICS that resulted from BRS and CSOM. Materials and Methods: All patients that presented to the Otorhinolaryngological department and Neurosurgical unit of the same institution with clinical and radiological features of CSOM, BRS, and ICS were prospectively studied over a 5-year period. Patients were followed up for a minimum of 3 months. Results: Two thousand, two hundred and seventy-nine patients presented during the 5-year study period. Of all these patients, 1511 had CSOM (66.3%) and 768 (33.7%) presented with features of BRS. Eleven (0.73%) had ICS complicating their CSOM while 8 (1.04%) cases of surgically treated ICS followed BRS. Bacterial rhinosinusitis was not more likely to lead to ICS (P = 0.4348). The Odds ratio (OR) of a child ≤ 18 years of age with CSOM developing ICS was 5.24 (95% Confidence interval 1.13-24.34; P = 0.0345), while it was 7.60 (95% Confidence interval 1.52-37.97; P = 0.0134) for children with BRS. Conclusions: The most common type of ICS complicating CSOM and BRS was brain abscess and subdural empyema, respectively. Children are more prone to develop surgical ICS following CSOM and BRS. The proportion of males that had ICS was higher in both CSOM and BRS patients. Optimal outcome is achieved in patients that presented with GCS of 13 and above.
Trichophagia along with trichobezoar in the absence of trichotillomania
Authors: Mehra Aseem , Avasthi Ajit , Gupta Vikas , Grover Sandeep 
Published: November 2014

ABSTRACTTrichobezoars are rarely described in the absence of trichotillomania. In this report we present a case of trichobezoar associated with trichophagia in the absence of trichotillomania. A 16-year-old girl presented to surgery outpatient with complaints of pain in abdomen and vomiting for the last 6 months. Physical examination revealed a 14 × 16 cm firm, tender, mass with smooth surface, irregular margins, which was mobile with respiration. Ultrasound abdomen revealed a bizarre lesion in the right upper and middle abdomen suggestive of gastric bezoars. Upper gastrointestinal endoscopy did not reveal any abnormality in the esophagus and showed a large mobile mass in the stomach. In view of trichobezoar, psychiatry consultation was sought. Exploration of history revealed that the patient was eating hairs and clay since early childhood. As per patient she would eat hairs thrown by others. She would like the taste of hair and had strong persistent desire to eat hair and would go out searching for the same. At times she would also eat clay. However, she denied of pulling her own hairs. Physical examination of scalp and other body parts did not show any evidence of alopecia or pulling of hair/short hair. She was managed surgically and was counseled about the consequences of eating hairs and clays and was encouraged not to eat hair. To conclude our case suggests that patients can have trichobezoar and trichophagia even in the absence of trichotillomania.
Cerebellar ataxia in a young patient: A rare path to lupus
Authors: Ghosh Kaushik , Chatterjee Atri , Ghosh Susmita , Chakraborty Sisir 
Published: November 2014

ABSTRACTCerebellar ataxia is a rare manifestation of neuropsychiatric systemic lupus erythematosus (SLE). Development of vasculitic infarcts in the cerebellum is the most plausible reason of this manifestation. We report the case of a patient who presented with characteristic skin rashes of lupus along with cerebellar signs. Imaging of brain in this patient revealed prominent cerebellar atrophy. She was treated with mycophenolate mofetil and oral corticosteroid, and there was no further progression of her neurological signs after the initiation of therapy. In the clinical context of varied presentations of neurolupus, this is one of the rare sightings and our treatment protocol holds promise as first-line therapy in future.
Mania following organophosphate poisoning
Authors: Mohapatra Satyakam , Rath Neelmadhav 
Published: November 2014

ABSTRACTOrganophosphate poisoning is the most common poisoning in developing countries. Although the acute muscarinic and nicotinic side-effects of organophosphate poisoning are well known and easily recognized, but neuropsychiatric changes are rarely reported. We are reporting a case of a 33-year-old female who developed manic episode following acute organophosphate poisoning.
On Memory, Forgetting, and Complicity in “The Cask of Amontillado”
Authors: DiSanza Raymond 
Published: November 2014

Abstract
This article explores the relationship between audience, the motive for murder, and narrative purpose in Poe's “The Cask of Amontillado,” arguing ultimately that the various questions raised by these aspects of the text are far more interconnected than has frequently been acknowledged. It challenges many of the stock interpretations of the story in an effort to open up more fruitful avenues for exploring one of Poe's most noteworthy masterpieces. The primary focus of the article is on the nature of audience complicity generally in the horror genre, and, more specifically, within Poe's story, and how that complicity is at the heart of the most effective horror stories.
Renverser la tendance à la pauvreté au travail en instaurant un revenu minimum garanti au Québec ?
Authors: Boucher1 Marie-Pierre 
Published: November 2014

Qu’elle soit nommée « allocation universelle », « impôt négatif », « revenu de citoyenneté » ou « revenu minimum garanti », l’idée d’un revenu de base inconditionnel continue d’alimenter les passions et les réflexions au Québec, en Europe et ailleurs dans le monde. Le revenu minimum garanti est une mesure de soutien du revenu ou de lutte contre la pauvreté intégrée à la fiscalité. Cet article présente l’une des périodes de l’examen de la faisabilité de l’implantation d’un revenu minimum garanti, dans les années 1970 au Canada et au Québec. Cette période est mise en parallèle avec l’instauration de l’aide sociale en 1969, puis avec les réformes néolibérales des systèmes de protection sociale canadien et québécois des dernières décennies. Nous examinerons ces réformes au regard de la gestion de la main-d’oeuvre de la politique sociale, laquelle participe, par l’activation, à la segmentation flexible du système d’emploi.
Zeo‐Click Synthesis: Copper‐Zeolite‐Catalyzed Synthesis of Ynamides
Authors: Harkat Hassina , Borghèse Sophie , Nigris Matteo De , Kiselev Serguei , Bénéteau Valérie , Pale Patrick 
Published: November 2014

AbstractCopper(I)‐zeolites, especially copper(I)‐ultra stable Y zeolite (USY), are very efficient heterogeneous catalysts for the coupling of functionalized 1‐bromoalkynes and various nitrogen derivatives. Under these conditions, sulfonylated alkyl‐ or arylamines and various N‐heterocycles, such as oxazolidinones or indoles, could be efficiently transformed into the corresponding N‐alkynyl derivatives. However, imidazoles gave addition products rather than coupling products. The reaction conditions proved compatible with a variety of functional and protecting groups. Such zeolitic catalysts can be recycled and reused at least five times without significant deactivation. Low catalyst loading could be used (4 mol%) and as low as 0.8 mol% of this heterogeneous copper catalyst still gave good conversion and yields.magnified image
Acute calcific prevertebral tendinitis: rare cause of neck pain
Authors: Chen Chia‐Hsi , Lu Ying‐Chou , Wong Tak‐Yee 
Published: November 2014

CaseWe report a case of acute calcific prevertebral tendinitis and discuss the clinical signs, symptoms, and radiologic findings of the disease.OutcomeThis 47‐year‐old man suffered from neck pain, odynophagia, and sore throat for 2 days. Acute calcific prevertebral tendinitis was noted. This disease, brought on by prolonged minor repetitive tendon injury, is an often overlooked cause of acute neck pain. The typical radiologic appearances of the disease include the calcification of the anterior surface of the C1–C2 spine and smooth soft tissue swelling over the retropharyngeal space.ConclusionGenerally this disease is benign and may be misdiagnosed as deep neck infection. Drainage on this patient would be considered malpractice.
Mechanistic Studies of the Radical S‐Adenosylmethionine Enzyme DesII with TDP‐D‐Fucose
Authors: Ko Yeonjin , Ruszczycky Mark W. , Choi Sei‐Hyun , Liu Hung‐wen 
Published: November 2014

AbstractDesII is a radical S‐adenosylmethionine (SAM) enzyme that catalyzes the C4‐deamination of TDP‐4‐amino‐4,6‐dideoxyglucose through a C3 radical intermediate. However, if the C4 amino group is replaced with a hydroxy group (to give TDP‐quinovose), the hydroxy group at C3 is oxidized to a ketone with no C4‐dehydration. It is hypothesized that hyperconjugation between the C4 CN/O bond and the partially filled p orbital at C3 of the radical intermediate modulates the degree to which elimination competes with dehydrogenation. To investigate this hypothesis, the reaction of DesII with the C4‐epimer of TDP‐quinovose (TDP‐fucose) was examined. The reaction primarily results in the formation of TDP‐6‐deoxygulose and likely regeneration of TDP‐fucose. The remainder of the substrate radical partitions roughly equally between C3‐dehydrogenation and C4‐dehydration. Thus, changing the stereochemistry at C4 permits a more balanced competition between elimination and dehydrogenation.
pH‐Responsive Non‐Ionic Diblock Copolymers: Ionization of Carboxylic Acid End‐Groups Induces an Order–Order Morphological Transition
Authors: Lovett Joseph R. , Warren Nicholas J. , Ratcliffe Liam P. D. , Kocik Marzena K. , Armes Steven P. 
Published: November 2014

AbstractA carboxylic acid based reversible additionfragmentation transfer (RAFT) agent is used to prepare gels composed of worm‐like diblock copolymers using two non‐ionic monomers, glycerol monomethacrylate (GMA) and 2‐hydroxypropyl methacrylate (HPMA). Ionization of the carboxylic acid end‐group on the PGMA stabilizer block induces a worm‐to‐sphere transition, which in turn causes immediate degelation. This morphological transition is fully reversible as determined by TEM and rheology studies and occurs because of a subtle change in the packing parameter for the copolymer chains. A control experiment where the methyl ester derivative of the RAFT agent is used to prepare the same diblock copolymer confirms that no pH‐responsive behavior occurs in this case. This end‐group ionization approach is important for the design of new pH‐responsive copolymer nano‐objects as, unlike polyacids or polybases, only a minimal amount of added base (or acid) is required to drive the morphological transition.
Comparison of Anodic TiO2‐Nanotube Membranes used for Frontside‐Illuminated Dye‐Sensitized Solar Cells
Authors: Mohammadpour Fatemeh , Moradi Mahmood , Cha Gihoon , So Seulgi , Lee Kiyoung , Altomare Marco , Schmuki Patrik 
Published: November 2014

AbstractIn the present work we compare TiO2‐nanotube lift‐off strategies for the construction of frontside‐illuminated dye‐sensitized solar cells (DSSCs). Anodic nanotube layers were detached from the metallic back contact by using different techniques and transferred onto a fluorine‐doped tin oxide substrate. We show that if we use an optimized potential step treatment to fabricate membranes, DSSC efficiencies can be significantly increased (η>8 %). The improved efficiency is ascribed to higher specific dye loading and enhanced electron‐transport properties of optimally fabricated TiO2‐nanotube membranes.
Versatile Bisethynyl[60]fulleropyrrolidine Scaffolds for Mimicking Artificial Light‐Harvesting Photoreaction Centers
Authors: Kremer Adrian , Bietlot Emerance , Zanelli Alberto , Malicka Joanna M. , Armaroli Nicola , Bonifazi Davide 
Published: November 2014

AbstractFullerene‐based tetrads, triads, and dyads are presented in which [60]fulleropyrrolidine synthons are linked to an oligo(p‐phenyleneethynylene) antenna at the nitrogen atom and to electron‐donor phenothiazine (PTZ) and/or ferrocene (Fc) moieties at the α carbon of the pyrrolidine cycle through an acetylene spacer. Cyclic voltammetry and UV/ Vis absorption spectra evidence negligible ground‐state electronic interactions among the subunits. By contrast, strong excited‐state interactions are detected upon selective light irradiation of the antenna (UV) or of the fullerene scaffold (Vis). When only PTZ is present as electron donor, photoinduced electron transfer to the fullerene unit is unambiguously detected in benzonitrile, but this is not the case when Fc is part of the multicomponent system. These results suggest that Fc is a formidable energy transfer quencher and caution should be used in choosing it as electron donor to promote efficient charge separation in multicomponent arrays.
Chemoselective Bioconjugation of Triazole Phosphonites in Aqueous Media
Authors: Vallée M. Robert J. , Majkut Paul , Krause Dagmar , Gerrits Michael , Hackenberger Christian P. R. 
Published: November 2014

AbstractReadily accessible and versatile phosphonite building blocks with improved stability against hydrolysis were used for the efficient metal‐free functionalization of peptides and proteins in aqueous buffers at low micromolar concentrations. The application of this protocol to the immobilization of a Rasa1‐SH2 domain revealed high binding affinity to the human T‐cell protein ADAP and supports the applicability of triazole phosphonites for protein modifications without harming their function.
Fluorescence‐Labeled Bis‐benzamidines as Fluorogenic DNA Minor‐Groove Binders: Photophysics and Binding Dynamics
Authors: Bordello Jorge , Sánchez Mateo I. , Vázquez M. Eugenio , Mascareñas José L. , Al‐Soufi Wajih , Novo Mercedes 
Published: November 2014

AbstractIn recent decades there has been great interest in the design of highly sensitive sequence‐specific DNA binders. The eligibility of the binder depends on the magnitude of the fluorescence increase upon binding, related to its photophysics, and on its affinity and specificity, which is, in turn, determined by the dynamics of the binding process. Therefore, progress in the design of DNA binders requires both thorough photophysical studies and precise determination of the association and dissociation rate constants involved. We have studied two bis‐benzamidine (BBA) derivatives labeled by linkers of various lengths with the dye Oregon Green (OG). These fluorogenic binders show a dramatic fluorescence enhancement upon binding to the minor groove of double‐stranded (ds) DNA, as well as significant improvement in their sequence specificity versus the parent BBA, although with decreased affinity constants. Detailed photophysical analysis shows that static and dynamic quenching of the OG fluorescence by BBA through photoinduced electron transfer is suppressed upon insertion of BBA into the minor groove of DNA. Fluorescence correlation spectroscopy yields precise dynamic rate constants that prove that the association process of these fluorogenic binders to dsDNA is very similar to that of BBA alone and that their lower affinity is mainly a consequence of their weaker attachment to the minor groove and the resultant faster dissociation process. The conclusions of this study will allow us to go one step further in the design of new DNA binders with tunable fluorescence and binding properties.
Dual Photo‐functionalized Amphiphile for Photo‐reversible Liquid Crystal Alignments
Authors: Kim Dae‐Yoon , Lee Sang‐A , Park Minwook , Jeong Kwang‐Un 
Published: November 2014

AbstractWithout the conventional polymer‐based liquid crystal (LC) alignment process, a newly synthesized dual photo‐functionalized amphiphile (abbreviated as ADMA1) was successfully applied as a robust photo‐reversible LC alignment layer by self‐assembly and photo‐polymerization. The LC alignment layer constructed by directly adding dual photo‐functionalized amphiphiles into LC media significantly cuts the manufacturing cost as well as opens new doors for the fabrication of novel electro‐optical devices.
Dative Au→Al Interactions: Crystallographic Characterization and Computational Analysis
Authors: Devillard Marc , Nicolas Emmanuel , Ehlers Andreas W. , Backs Jana , Mallet‐Ladeira Sonia , Bouhadir Ghenwa , Slootweg J. Chris , Uhl Werner , Bourissou Didier 
Published: November 2014

AbstractHitherto unknown Au→Al interactions have been evidenced upon coordination of the geminal phosphorus–aluminum Lewis pair Mes2PC(CHPh)AltBu2 (Mes=2,4,6‐trimethylphenyl). Four different gold(I) complexes featuring alkyl (Me), aryl (Ph, C6F5), and alkynyl (CCPh) co‐ligands have been prepared. X‐ray diffraction analyses show that P→Au→Al bridging coordination induces noticeable bending of the ligand (the PCAl bond angle shrinks by 13°). This new type of transition metal→Lewis acid interaction has been analyzed by DFT calculations.
Effects of Catalyst Pore Structure and Acid Properties on the Dehydration of Glycerol
Authors: Choi Youngbo , Park Hongseok , Yun Yang Sik , Yi Jongheop 
Published: November 2014

AbstractHierarchical porous catalysts have recently attracted increasing interest because of the enhanced accessibility to active sites on such materials. In this context, previously reported hierarchically mesoporous ASN and ASPN materials are evaluated by applying them to the dehydration of glycerol, and demonstrate excellent catalytic performance. In addition, a comprehensive understanding of the effects of pore structures and the acid properties on the reaction through comparative studies with microporous HZSM‐5 and mesoporous AlMCM‐41 is provided.
Structural and Morphological Transformations of In–MIL‐68‐Based Hexagonal Lumps to QMOF‐2‐Based Pointed Hexagonal Rods by Means of Destruction and Reconstruction Processes
Authors: Choi Sora , Lee Hee Jung , Kim Taeho , Oh Moonhyun 
Published: November 2014

AbstractSimple thermal treatment of three‐dimensional Kagomé‐like [In(OH)(BDC)]n (In–MIL‐68) hexagonal lumps in the presence of an extra amount of 1,4‐benzenedicarboxylic acid (H2BDC) induces structural and morphological transformations of the hexagonal lumps into three‐dimensional quartz‐structured [InH(BDC)2]n (QMOF‐2) pointed hexagonal rods. Transformation processes have been monitored by scanning electron microscopy to verify the destruction of the In–MIL‐68‐based hexagonal lumps and the simultaneous reconstruction of QMOF‐2‐based pointed hexagonal rods. We have also discovered the production of In–MIL‐68‐based hexagonal wires as early‐stage kinetic products and the generation of QMOF‐2‐based pointed hexagonal rods as final‐stage thermodynamic products from one‐step solvothermal reaction of In(NO3)3 with an excess amount of H2BDC.