bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characteristics and information searched for by French patients with systemic lupus erythematosus: A web-community data-driven online survey
Authors: Meunier B , Jourde-Chiche N , Mancini J , Chekroun M , Retornaz F , Chiche L 
Published: October 2015

Introduction To provide information about the needs of patients with systemic lupus erythematosus (SLE) using Carenity, the first European online platform for patients with chronic diseases. Methods At one year after its creation, all posts from the Carenity SLE community were collected and analysed. A focused cross-sectional online survey was performed. Results The SLE community included 521 people (93% females; mean age: 39.8 years). Among a total of 6702 posts, 2232 were classified according to disease-related topics. The 10 most common topics were ‘lupus and …’ either ‘treatment’, ‘fatigue’, ‘entourage’, ‘sun exposure’, ‘diagnosis’, ‘autoimmune diseases’, ‘pregnancy’, ‘contraception’, ‘symptoms’ or ‘sexuality’. 112 SLE patients participated in the online survey. At the time of diagnosis, only 17 (15%) patients had heard of SLE and 84 (75%) expressed a need for more information on outcomes (27%), treatments (27%), daily life (14%), patients' associations (11%), symptoms (8%), the disease (8%) and psychosocial aspects (7%). When treatment was initiated, 48 patients (43%) would have liked more information about side effects (46%), long-term effects (21%), treatment duration/cessation (12.5%) and type (10%) and mechanism of action (8%) of treatments. All participants except one had used the internet to find information about SLE. Sources of information included healthcare providers (51%/61%/67%), journals/magazines (7%/12%/6%), lupus Websites (51%/77%/40%), web forums/blogs (34%/53%/19%), patients' associations (11%/23%/9%) accessed at ‘just before diagnosis’, ‘just after diagnosis’ and ‘before treatment initiation’. Conclusions Online patient communities provide original unbiased information that can help improve provision of information to SLE patients.
Pilot randomised controlled trial of Help4Mood, an embodied virtual agent-based system to support treatment of depression
Authors: Burton Christopher , Szentagotai Tatar Aurora , McKinstry Brian , Matheson Colin , Matu Silviu , Moldovan Ramona , Macnab Michele , Farrow Elaine , David Daniel , Pagliari Claudia , Serrano Blanco Antoni , Wolters Maria ,   for the Help4Mood Consortium
Published: October 2015

Introduction Help4Mood is an interactive system with an embodied virtual agent (avatar) to assist in self-monitoring of patients receiving treatment for depression. Help4Mood supports self-report and biometric monitoring and includes elements of cognitive behavioural therapy. We aimed to evaluate system use and acceptability, to explore likely recruitment and retention rates in a clinical trial and to obtain an estimate of potential treatment response with a view to conducting a future randomised controlled trial (RCT). Methods We conducted a pilot RCT of Help4Mood in three centres, in Romania, Spain and Scotland, UK. Patients with diagnosed depression (major depressive disorder) and current mild/moderate depressive symptoms were randomised to use the system for four weeks in addition to treatment as usual (TAU) or to TAU alone. Results Twenty-seven individuals were randomised and follow-up data were obtained from 21 participants (12/13 Help4Mood, 9/14 TAU). Half of participants randomised to Help4Mood used it regularly (more than 10 times); none used it every day. Acceptability varied between users. Some valued the emotional responsiveness of the system, while others found it too repetitive. Intention to treat analysis showed a small difference in change of Beck Depression Inventory II (BDI-2) scores (Help4Mood –5.7 points, TAU –4.2). Post-hoc on-treatment analysis suggested that participants who used Help4Mood regularly experienced a median change in BDI-2 of –8 points. Conclusion Help4Mood is acceptable to some patients receiving treatment for depression although none used it as regularly as intended. Changes in depression symptoms in individuals who used the system regularly reached potentially meaningful levels.
POR QUE A CIÊNCIA NÃO RESOLVE NOSSOS PROBLEMAS?
Authors: Durante Daniel 
Published: October 2015

Além de responder à pergunta título, pretende-se também apresentar as linhas gerais de um caminho que vem sendo proposto por alguns pensadores sobre de que modo a ciência poderia se modificar de modo a que pudéssemos utilizá-la para resolver nossos principais problemas. Para tanto iniciaremos explicitando o que consideramos as características mais fundamentais da racionalidade científica hegemônica, a saber: o atomismo e o método axiomático. Em seguida, apresentamos alguns conhecidos problemas das ciências, evidenciando suas relações com estas características fundamentais. Tais problemas são tanto epistemológicos e metodológicos, internos ao próprio conhecimento, quanto éticos, relacionados às suas consequências. Em seguida, indicamos como a forte interconexão destes dois tipos de problemas pode ser compreendida quando entendemos a ciência de modo instrumental como uma resposta ao interesse de previsão para manipulação e controle. Por fim, partindo do reconhecimento do caráter contingente e socialmente construído do conhecimento científico, inclusive de suas características fundamentais, respondemos à questão título e apontamos, ainda de modo incipiente, algumas possibilidades de modificações metodológicas que têm sido propostas nos últimos anos. Em especial, apresentamos as que foram rotuladas de complexidade e a transdisciplinaridade, indicando algumas questões e possíveis linhas de pesquisa que estas abordagens suscitam.
FaNGaS: Fast Neutron Gamma Spectroscopy instrument for prompt gamma signature of inelastic scattering reactions
Authors: Rossbach Matthias , Mauerhofer Eric 
Published: October 2015

The FaNGaS instrument has been developed and constructed at the Forschungszentrum Jülich GmbH for investigation of neutron inelastic scattering reactions using the fission neutron beam SR10 at the Forschungsneutronenquelle Heinz Maier-Leibnitz (FRM II) operated by the Technische Universität München in Garching. Prompt emitted gamma rays from excited states of irradiated elements can be used for analytical purposes.
Improvement of Therapy Outcomes after Negative Pressure Wound Therapy in a Patient with Acne inversa.
Authors: Francuzik Wojciech , Banasiewicz Tomasz , Adamski Zygmunt 
Published: October 2015

Treatment of acne inversa (also known as hidradenitis suppurativa) is complicated and chronic. This debilitating, inflammatory disease of the follicular sacks affects mostly young adults and has a strong negative impact on their quality of life. We present a case of a 28 year old woman with a history of acneinversa of Hurley grade 2 for 6 years. Patient underwent surgical excision of the skin of the left inguinum followed by negative pressure therapy dressings for 2 and a half weeks (5 dressing changes). This allowed a full closure of the wound after 12 weeks and formation of a well accepted scar. Patient’s paindecreased from 4.5 to 1.5 according to visual assessment scale. We also noted a 28 point decrease in disease severity score according to Sartorius scale and a 19 point decrease in Dermatology Life Quality Index. Two years prior admission patient had undergone surgical treatment of her right inguinum with split thickness skin grafting, which healed for 26 weeks and yielded less satisfactory results. Comparison photographs of both treatment results are presented.
Endoluminal Negative Pressure Wound Therapy (E-NPWT) for anastomotic leakage after rectal resection
Authors: Runkel Norbert Severin Friedrich , Birk Mechthilde 
Published: October 2015

Background Local management of anastomotic leakage after rectal cancer resection has traditionally consisted of rinsing and drainage. Transanal endoluminal application of NPWT (E-NPWT or endo-VAC or endo-sponge) is an interesting novel concept that has been explored in a few studies and case series over the last decade. We report herein our institutional experience over a three year period during which E-NPWT was the local treatment of choice for all cases with anastomotic leakage after rectal resection.Patients and MethodsThis study retrospectively evaluated the clinical charts of 147 consecutive patients who underwent anterior rectal resection from 2011-2013. A postoperative anastomotic leak occurred in eight (5%) patients from two straight anastomoses, one side-to-end construction, and five colonic pouches. All patients had undergone curative anterior resection with diverting ostomy. Transanal debridement and application of a trimmed foam were performed by rigid or fexibel endoscopy and started without delay after confirmation of diagnosis in seven patients 8-15 days postoperatively. In one patient E-NPWT began after failed fibrin-glue treatment 6 weeks later. The foams were connected to a standard vacuum pump with the pressure set at -70mmHg in a continuous mode. E-NPWT was maintained for a median period of 10 (5-25) days. The treatment intervals were typically 2-3 days.ResultsComplete healing was achieved in three cases during E-NPWT. In the remaining five patients, the defect reduced in size to allow further spontaneous healing. This occurred twice. One persistent sinus was successfully sealed with fibrin glue. One persisting recto-vaginal fistula required surgical closure. One large defect secondary to ischemic pouch necrosis required secondary pouch explantation and permanent colostomy. The overall ileostomy reversal rate was 75%.ConclusionE-NPWT is feasible and without severe side effects. Early initiation prevents septic progression and results in a high closure rate in patients with pelvic leakage. Although complete healing is not achieved in recto-vaginal fistulas or ischemic necrosis of the neorectum, E-NPWT may play a potential role in bridging and damage control.
The Relationship of Osteoprotegerin, Matrix Gla Protein, and HbA1C in Controlled and Uncontrolled Type 2 Diabetes Mellitus Patients
Authors: Daulay Dwi Yuniati , Donosepoetro Marsetio , Kasiman Sutomo 
Published: October 2015

BACKGROUND: Many studies have reported that diabetes mellitus correlates with vascular calcification event that increases progressively in uncontrolled diabetes. Osteoprotegerin (OPG) is known to act as a promoter in vascular calcification, contrary to Matrix Gla Protein (MGP), which is an inhibitor in vascular calcification. The aim of this study was to observe the progress of vascular calcification in uncontrolled diabetes patients by assessing biochemical markers OPG as promoter and MGP as inhibitor in vascular calcification.METHODS: This was an observational study with cross sectional design on adult male patients with type 2 diabetes mellitus, defined by DM Consensus Criteria Indonesia, 2006.RESULTS: The results of this study showed that there was a positive significant correlation between OPG and HbA1c (r=0.261, p=0.030), in contrast with MGP that showed no significant correlation with HbA1c. OPG also correlated significantly with Fasting Plasma Glucose (r=0.261, p=0.014). In uncontrolled diabetes group there was positive significant correlation between OPG and HbA1c (r=0.397, p=0.014). There was no significant difference found in the levels of OPG in controlled and uncontrolled diabetes groups (p=0.567), but OPG/MGP index showed higher difference (p=0.259). The OPG/MGP index also had positive significant correlation with HbA1c (r=0.285, p=0.018) and Fasting Plasma Glucose (r=0.313, p=0.009).CONCLUSIONS: This study suggested progress to vascular calcification in uncontrolled type 2 diabetes mellitus. The use of vascular calcification biomarkers are recommended to predict/detect vascular calcification event in type 2 diabetes mellitus patients.KEYWORDS: type 2 diabetes mellitus, vascular calcification, OPG, MGP, HbA1c
Correlation of Apo B-48 and Apo B-100 with Oxidized LDL in Men with Central Obesity
Authors: Fibriani Maria Diah , Wijaya Andi , Bahar Burhanuddin 
Published: October 2015

BACKGROUND: Obesity has a central role in the metabolic syndrome, which raises the risk for atherosclerotic cardiovascular disease (ASVCD). Apo B-48 and Apo B-100 are the necessary structural proteins required for the assembly and secretion of chylomicron and VLDL which have role in atherogenesis. The key initiating process in atherogenesis is the subendothelial retention of apolipoprotein B-containing lipoproteins. Oxidation of LDL is a hallmark of atherosclerosis development. The aim of this study was to asses the association between Apo B-48 and Apo B-100 with Oxidized-LDL as marker of atherosclerosis risk in central obesity. We hope that the result of this study can help to make a new strategy for the prevention and treatment of vascular disease.RESULTS: There were 68 patients aged 39.6±7.3 years, Apo B-48 concentration was 7.47±5.36 μg/mL, Apo B-100 was 117.26±25.74 mg/dL, and ox-LDL was 137.05±18.88 U/L. This study showed a significant correlation between Apo B-100 and ox-LDL (r=0.608, p<0.05) and correlation between Apo B-48 and ox-LDL (r=0.171, p<0.05). The levels of Apo B-100 were significantly different between obese with Mets and obese without Mets individuals (p<0.05).CONCLUSIONS: This study suggested that Apo B-100 concentration increase in obese in Mets as compared with obese without Mets. Apo B-48 and Apo B-100 were correlated with Oxidized LDL, but correlation between Apo B-100 and ox-LDL more significant that Apo B-48and ox-LDL.KEYWORDS: obesity, atherogenesis, Apo B-48, Apo B-100, ox-LDL
Correlation of Ferritin and Transferrin Serum with hsCRP and F2-Isoprostane in Metabolic Syndrome
Authors: Nurfina Waode , Yusuf Irawan , Arif Mansyur 
Published: October 2015

BACKGROUND: The low inflammatory state that accompanies the Metabolic Syndrome (MetS) associates with the overexpression of oxidative stress. Ferritin and Transferrin serum are often used to measure iron status and their concentrations are altered in several metabolic conditions. We hypothesized that concentration of Ferritin and Transferrin serum increase in Metabolic Syndrome (MetS) and correlate with the inflammation and oxidative stress.METHODS: We studied 65 male MetS patients, aged 43.26±7.16 years. Iron metabolism was measured by concentration of Ferritin and Transferrin serums, while inflammatory and oxidative stress by high sensitivity C-reactive Protein (hsCRP) and F2-Isoprostane.RESULTS: Concentration of Ferritin 315.70±188.63 ng/L and Transferrin 2.36±0.31 g/L increased along with increasing components of MetS. Concentration of Ferritin serum had a positive correlation with hsCRP (r=0.220) and F2-Isoprostane (r=0.023).CONCLUSION: Serum concentration of Ferritin increased in the MetS and correlates with hsCRP and F2-Isoprostane.KEYWORDS: metabolic syndrome, ferritin, transferrin, hsCRP, F2-isoprostane
MicroRNAs in Obesity, Metabolic Syndrome and Diabetes Mellitus
Authors: Meiliana Anna , Wijaya Andi 
Published: October 2015

BACKGROUND: MicroRNAs (miRNAs) are small regulatory RNAs that play important roles in development of diseases. Several studies have provided evidences showing that miRNAs affect pathways that are fundamental for metabolic control in adipocyte and skeletal muscle differentiations. Some miRNAs have been implicated in lipid, amino acid, and glucose homeostasis. This leads to the possibility that miRNAs may contribute to common metabolic diseases and point to novel therapeutic opportunities based on targeting of miRNAs.CONTENT: miRNAs have been recognized as a class of epigenetic regulators of metabolism and energy homeostasis, primarily because the simultaneous regulation of a large number of target genes can be accomplished by a single miRNA. Emerging evidences suggest that miRNAs play a key role in the pathological development of obesity by affecting adipocyte differentiation. miRNAs have been implicated as novel protagonists in the pathogenesis of Diabetes Mellitus (DM), regulation of insulin production, secretion and action. They also appear to play a role in the development of diabetic complications such as nephropathy and cardiac hypertrophy.SUMMARY: Involvement of miRNAs in glucose and lipid metabolism has provided strong evidences to confirm their roles as key players in regulation of complex metabolic pathways. Additionally, it indicates potential outlook for novel therapeutic strategies in the management of obesity, metabolic syndrome and DM. Further research in this field is needed to ascertain the full potential of miRNAs as novel metabolic biomarkers and potent therapeutic agents against obesity and its metabolic disorders.KEYWORDS: obesity, metabolic syndrome, diabetes, miRNAs, adipogenesis, insulin, pancreatic cells
Correlation between hsCRP and Anti-beta2GPI Antibody in Metabolic Syndrome
Authors: Djohari Meiriza , Arif Mansyur , Bahar Burhanuddin 
Published: October 2015

BACKGROUND: Several researches reported that inflammatory and immunological mechanism such as autoantibody to β2-glycoprotein I (anti β2GPI) appear as related factors in initiation and progress of atherosclerosis lesion in patient with autoimmune disease. Antibody to β2GPI titers are correlated with atherosclerosis and in vitro studies showed that they enhance oxidized low density lipoprotein (ox-LDL) uptake by macrophages. Immunization with auto-antigen β2GPI elicits an immune response to influence lesion progression that mostly happens in autoimmune subjects. The metabolic syndrome (MetS) is combination of several metabolic disorders such as obesity, dyslipidemia, Diabetes Mellitus (DM) and conditions due to inflammation and stress oxidative. The Correlation between inflammatory markers such as High sensitivity C-Reactive Protein (hsCRP) and anti-β2GPI antibody in MetS needs to be further investigated.METHODS: This was an observational study with cross sectional design on subject with MetS as determined by the International Diabetes Federation (IDF) 2005’s criteria.RESULTS:There was a positive and significant correlation between hsCRP and anti-β2GPI antibody in MetS group (r=0.406; p≤0.05) as compared to non-MetS group. We found that there was elevated level of anti-β2GPI antibody in hsCRP of 3-10 mg/L.CONCLUSIONS: Anti-β2GPI antibody may be elevated in subjects with MetS who have low grade of inflammation as shown by hsCRP.KEYWORDS: metabolic syndrome, inflammation, autoantigen, atherosclerosis, obesity
Diurnal variation of winter F region ionosphere for solar minimum at both Zhongshan Station, Antarctica, and Svalbard Station, Arctic
Authors: Zhang Bei‐Chen , Yang Sheng‐Gao , Xu Sheng , Liu Rui‐Yuan , Häggström I. , Zhang Qing‐He , Hu Ze‐Jun , Huang De‐Hong , Hu Hong‐Qiao 
Published: October 2015

AbstractDiurnal variation features of wintertime F2 peak electron density (NmF2) representative for solar minimum at both Zhongshan station, Antarctica, and Svalbard station are compared and analyzed. Both stations are located around cusp latitude and are almost on the same geomagnetic meridian plane in both hemispheres. For quiet time period, typical NmF2 diurnal variation features at Svalbard station show double peaks with a decrease of NmF2 around magnetic local noon (~UT + 3 h); NmF2 diurnal variation at Zhongshan station shows one major peak around magnetic local noon (~UT + 1.75 h), followed by a sharp decrease of NmF2, and a subpeak around 1500 UT. Simulation results of the high‐latitude ionospheres in both hemispheres agree well with observations at both stations. It is found that the major difference of NmF2 variation between both stations can be explained by the unique location of each station relative to the sunlit demarcation line during the day. For quiet time period, photoionization from lower latitude contributes to the major peak of NmF2 in the diurnal variation at Zhongshan station, while the interaction between horizontal convection and auroral precipitation is the main cause for NmF2 variation at Svalbard station. For active time period, both stations show the increase of NmF2 due to transportation of higher plasma density from lower latitudes on the dayside with the expansion of the polar cap and the additional ionization from soft‐precipitating electrons.
Observations of current sheets associated with solar wind reconnection exhausts passing through the near lunar wake
Authors: Xu Xiaojun , Wong Hon‐Cheng , Ma Yonghui , Wang Yi , Zuo Pingbing , Zhou Meng , Deng Xiaohua 
Published: October 2015

AbstractTwo reconnection exhausts were detected by one of the dual ARTEMIS orbiters in the solar wind near the Moon. Almost meanwhile, the other ARTEMIS orbiter encountered the two corresponding current sheets at the relatively marginal and central locations in the near lunar wake. Due to the Moon's direct absorption, the current density of the current sheet disappears within the wake. As a result, the wake magnetic field around the current sheets is changed. It is found that the variations of the magnetic field in the wake are primarily governed by two factors: diamagnetic current system at the wake boundary and the dropout of M direction currents (jM) within the wake. Instead of being almost unaltered as commonly assumed in the study of lunar wake, the magnetic field of the current sheets becomes potential with almost zero current density. With respect to the solar wind magnetic field, this potential magnetic field is weaker in the center and has an X line‐like configuration with significant normal components in the marginal portions of the wake. Our result may be applicable to nonconducting or weakly conducting contexts widely existing in the universe.
Reconstruction of the 236U input function for the Northeast Atlantic Ocean: Implications for 129I/236U and 236U/238U‐based tracer ages
Authors: Christl Marcus , Casacuberta Núria , Vockenhuber Christof , Elsässer Christoph , Bailly du Bois Pascal , Herrmann Jürgen , Synal Hans‐Arno 
Published: October 2015

AbstractA reconstruction of historical discharges of 236U into the Northeast Atlantic Ocean by nuclear installations is presented. The nuclear reprocessing facilities Sellafield (SF), Great Britain (GB) and La Hague (LH), France and potentially also the nuclear fuel processing installation Springfields (SP), GB represent the main contributors of 236U in the Northeast Atlantic Ocean. Because data on 236U releases is lacking, 236U discharges from SP and SF are estimated based on the U‐isotopic systematics found in the discharges from LH. The resulting reconstruction of 236U releases indicates that, until 2013, a total of (95 ± 32) kg of 236U was discharged from SF, SP, and LH. In a second step, the reconstructed 236U releases are combined with 129I data from literature and oceanic and atmospheric box models are used to derive the 129I/236U and 236U/238U input functions that, for example, can be used to calculate tracer ages of Atlantic Waters in the Arctic Ocean. Our conceptual results show that the combination of 129I/236U and 236U/238U generally allows the estimation of tracer ages over the past approximately 25 years if contributions of 236U from global fallout are considered. Finally, as a proof of concept, the new method is applied to calculate tracer ages of Arctic Ocean surface samples (collected in 2011/2012) and the results are in good agreement with literature data. We conclude that the combination of 129I/236U with 236U/238U in a dual tracer approach provides a sensitive tool for the calculation of tracer ages and ventilation rates in the North Atlantic region.