bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incidence of childhood cancers in the North East geopolitical zone of Nigeria
Authors: Suleiman Dauda Eneyamire , Adamu Adamu Saidu , Ezenkwa Uchenna Simon , Yusuf Maimuna Orahachi , Lawan Aliyu Ibrahim , Dachi Rufai Abdu , Bwala Kefas John , Liman Haruna Usman , Kabir Abba , Adamu Adamu Isa , Kolomi Modu Abubakar , Jimoh Abdulrazaq Ajanaku , Garba Ismaila Isa , Abdullahi Yusuf Mohammed , Audu Bala Mohammed 
Published: August 2024

IntroductionCancers are a major cause of childhood mortality worldwide especially in LMICs where underdiagnoses and lack of quality cancer data hampers effective cancer control efforts. This study aimed to document and describe the patterns and characteristics of childhood cancers in the North East geopolitical zone of Nigeria.MethodsThis was a retrospective cross-sectional study that collected cancer data from 4 out of the 6 states in the North East of Nigeria. The data included all malignancies diagnosed in children aged 0-19 years between 2019 and 2022. The age-specific incidence rates were also calculated for the individual 5-year age groups (0–4 years, 5–9 years, 10–14 years, and 15–19 years). The crude incidence rates (CIR) were calculated as the weighted averages of the respective ASRs in each age range within 0-14 years and 0-19 years respectively. The cancers were grouped according to the International Incidence of Childhood Cancers, volume 3 (IICC3).ResultsCancers in people &lt;20 years accounted for 7.3% of all cancers diagnosed over the same period. The crude incidence rates (CIR) for cancers in children and adolescents were 20.9 per million children aged 0-19 years and 18.8 per million children aged 0-14 years respectively, while the age-standardized rates (ASR) were 1.80 and 1.63 per million person-years respectively. There was a variation in the most commonly diagnosed cancers across all age groups. However, lymphomas were the most commonly diagnosed cancers overall, while CNS tumors were overwhelmingly rare.ConclusionDespite data limitations, this study provides useful insights into patterns of cancers in the region and will hopefully provide a basis for the strengthening of pediatric oncology care, childhood cancer control programs and population-based cancer registries.
A Mendelian randomization study of genetic liability to cutaneous melanoma and sunburns
Authors: Lu Fengmin , Wang Ling , Ma Xixing , Li Yanling 
Published: August 2024

BackgroundSome studies have reported that sunburns and cutaneous melanoma (CM) risk is increasing, but a clear causal link has yet to be established.MethodsThis current study conducted a two-sample Mendelian randomization (MR) approach to clarify the association and causality between sunburn history and CM using large-scale genome-wide association study data.ResultsThe inverse-variance weighted method result showed that sunburn might be associated with the risk of CM increasing (p = 2.21 × 10−23, OR = 1.034, 95% CI= 1.027-1.041), causally. The MR-Egger regression, weighted median method, simple mode method, and weighted mode method results showed similar results.ConclusionThis study offers evidence of sunburn history and increased risk of CM, and it shows that there might be common genetic basics regarding sunburns and CM susceptibility in Caucasian, European, or British ethnic groups.
A real-world disproportionality analysis of FDA adverse event reporting system (FAERS) events for denosumab
Authors: He Yue , Zhang Rong , Shen Huarui , Liu Yingqi 
Published: August 2024

BackgroundDenosumab is authorized to treat several diseases, including cancer and bone disorders. Nevertheless, its use in clinical practice has been affected by safety concerns. The work retrospectively investigated adverse events (AEs) of denosumab to better understand toxicities.MethodsThe FAERS data base data from Q1 of 2010 to Q3 of 2023 was chosen. The definition of Medical Dictionary for Regulatory Activities (MedDRA) was dependent on preferred terms (PTs) and system organ class (SOCs). Following the removal of duplicate reports, a disproportionality analysis was conducted to identify safety signals through the calculation of reporting odds ratios (ROR).ResultsDuring the reporting period, 130611 denosumab-related cases were identified; 670 pTs with a substantial disproportionality were retained. The connective and musculoskeletal tissue disorders, poisoning, injury, and procedural complications, as well as medical and surgical procedures, were among the important SOCs that satisfied the criteria. Reports at PT levels including off-label use, death, osteonecrosis of the jaw, arthralgia, and pain in extremities were determined. Severe consequences in terms of life-threatening injuries and death accounted for 841 and 19704 cases, respectively of the reported cases.ConclusionThese findings underscore the critical importance of pharmacovigilance and are consistent with established clinical observations. Notably, osteonecrosis of the jaw, arthralgia, pain in extremities, back pain, myalgia, and bone pain were identified as the most prevalent risk signals associated with denosumab.
The epigenetic signatures of opioid addiction and physical dependence are prevented by D-cysteine ethyl ester and betaine
Authors: McDonough Jennifer , Singhal Naveen K. , Getsy Paulina M. , Knies Katherine , Knauss Zackery T. , Mueller Devin , Bates James N. , Damron Derek S. , Lewis Stephen J. 
Published: August 2024

We have reported that D,L-thiol esters, including D-cysteine ethyl ester (D-CYSee), are effective at overcoming opioid-induced respiratory depression (OIRD) in rats. Our on-going studies reveal that co-injections of D-CYSee with multi-day morphine injections markedly diminish spontaneous withdrawal that usually occurs after cessation of multiple injections of morphine in rats. Chronically administered opioids are known (1) to alter cellular redox status, thus inducing an oxidative state, and (2) for an overall decrease in DNA methylation, therefore resulting in the transcriptional activation of previously silenced long interspersed elements (LINE-1) retrotransposon genes. The first objective of the present study was to determine whether D-CYSee and the one carbon metabolism with the methyl donor, betaine, would maintain redox control and normal DNA methylation levels in human neuroblastoma cell cultures (SH-SY5Y) under overnight challenge with morphine (100 nM). The second objective was to determine whether D-CYSee and/or betaine could diminish the degree of physical dependence to morphine in male Sprague Dawley rats. Our data showed that overnight treatment with morphine reduced cellular GSH levels, induced mitochondrial damage, decreased global DNA methylation, and increased LINE-1 mRNA expression. These adverse effects by morphine, which diminished the reducing capacity and compromised the maintenance of the membrane potential of SH-SY5Y cells, was prevented by concurrent application of D-CYSee (100 µM) or betaine (300 µM). Furthermore, our data demonstrated that co-injections of D-CYSee (250 μmol/kg, IV) and to a lesser extent, betaine (250 μmol/kg, IV), markedly diminished the development of physical dependence induced by multi-day morphine injections (escalating daily doses of 10–30 mg/kg, IV), as assessed by the lesser number of withdrawal phenomena elicited by the injection of the opioid receptor antagonist, naloxone (1.5 mg/kg, IV). These findings provide evidence that D-CYSee and betaine prevent the appearance of redox alterations and epigenetic signatures commonly seen in neural cells involved in opioid physical dependence/addiction, and lessen development of physical dependence to morphine.
Efficacy and safety of Ginkgolide with intravenous alteplase thrombolysis in acute ischemic stroke with large vessel occlusion: a subgroup analysis of GIANT
Authors: Zhang Zheyu , Zhong Wansi , Zhang Xuting , Ma Xiaodong , Lu Xudong , Zhang Meixia , Tao Anyang , Zhang Bing , Lou Min 
Published: August 2024

AimThis study aims to explore the effectiveness and safety of Ginkgolide® in acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) and moderate-to-severe stroke receiving intravenous alteplase thrombolysis (IVT).MethodsGinkgolide with Intravenous Alteplase Thrombolysis in Acute Ischemic Stroke Improving Neurological Function (GIANT) was an open-label, prospective, multicenter, cluster-randomized clinical trial and included AIS patients in 24 centers randomized to the intervention of intravenous Ginkgolide® or control group within the first 24 h after IVT. LVO was defined as any occlusion of the internal carotid artery, M1 or M2 of the middle cerebral artery, A1 or A2 of the anterior cerebral artery, P1 of the posterior cerebral artery, and V4 of the vertebral artery or the basilar artery. Stroke severity was assessed with the National Institutes of Health Stroke Scale (minor ≤5; moderate-to-severe &gt;5). The primary outcome was a good outcome, defined as a modified Rankin Scale (mRS) score of 0–2 at 90 days. Secondary outcomes were early neurological improvement (ENI), defined as ≥18% increase in the National Institutes of Health Stroke Scale (NIHSS) score at 7 days compared to baseline and distribution of mRS at 3 months.ResultsA total of 1,113 patients were included, with 268/913 (29.4%) presenting LVO and 508 (45.6%) presenting moderate-to-severe stroke. In patients with LVO, Ginkgolide® usage was independently associated with ENI (P = 0.001) but not with a good outcome (P = 0.154). In the moderate-to-severe stroke subgroup, Ginkgolide® was independently associated with both a good outcome (P = 0.009) and ENI (P = 0.028). Ginkgolide® did not increase the risk of hemorrhagic transformation (all P &gt; 0.05).ConclusionUsing Ginkgolide® within 24-h after intravenous rt-PA is effective and safe in LVO and moderate-to-severe stroke patients.
Multiclass small target detection algorithm for surface defects of chemicals special steel
Authors: Wang Yuanyuan , Yan Shaofeng , Abdullahi Hauwa Suleiman , Gao Shangbing , Zhang Haiyan , Chen Xiuchuan , Zhao Hu 
Published: August 2024

Introduction: Chemical special steels are widely used in chemical equipment manufacturing and other fields, and small defects on its surface (such as cracks and punches) are easy to cause serious accidents in harsh environments.Methods: In order to solve this problem, this paper proposes an improved defect detection algorithm for chemical special steel based on YOLOv8. Firstly, in order to effectively capture local and global information, a ParC2Net (Parallel-C2f) structure is proposed for feature extraction, which can accurately capture the subtle features of steel defects. Secondly, the loss function is adjusted to MPD-IOU, and its dynamic non-monotonic focusing characteristics are used to effectively solve the overfitting problem of the bounding box of low-quality targets. In addition, RepGFPN is used to fuse multi-scale features, deepen the interaction between semantics and spatial information, and significantly improve the efficiency of cross-layer information transmission. Finally, the RexSE-Head (ResNeXt-Squeeze-Excitation) design is adopted to enhance the positioning accuracy of small defect targets.Results and discussion: The experimental results show that the mAP@0.5 of the improved model reaches 93.5%, and the number of parameters is only 3.29M, which realizes the high precision and high response performance of the detection of small defects in chemical special steels, and highlights the practical application value of the model. The code is available at https://github.com/improvment/prs-yolo.
Hyperbaric intervention ameliorates the negative effects of long-term high-altitude exposure on cognitive control capacity
Authors: Ren Hong , Zhu Yun-Peng , Su Rui , Li Hao , Pan Yong-Yue 
Published: August 2024

IntroductionHypoxia due to reduced partial pressure of oxygen from high-altitude exposure affects the cognitive function of high-altitude migrants. Executive function is an important component of human cognitive function, characterized by high oxygen consumption during activity, and its level can be measured using cognitive control capacity (CCC). In addition, there is evidence for the potential value of hyperbaric oxygen (HBO) interventions in improving cognitive decline on the plateau. Therefore, the objective of this study was to investigate the effect of long-term high-altitude exposure on CCC in high-altitude newcomers and whether hyperbaric oxygen intervention has an ameliorative effect.MethodsThis study measured the magnitude of participants’ CCC using a Backward Masking Majority Function Task (MFT-M). Study 1 was a controlled study of different altitude conditions, with 64 participants in the high-altitude newcomer group and 64 participants in the low-altitude resident group, each completing the MFT-M task once. Study 2 was a controlled HBO intervention study in which newcomers who had lived at a high altitude for 2 years were randomly divided into the HBO group (n = 28) and control group (n = 28). 15 times hyperbaric oxygen interventions were performed in the HBO group. Subjects in both groups completed the MFT-M task once before and once after the intervention.ResultsStudy 1 showed that CCC was significantly higher in the low-altitude resident group than in the high-altitude newcomer group (p = 0.031). Study 2 showed that the CCC in the HBO group was significantly higher after 15 hyperbaric interventions than before (p = 0.005), while there was no significant difference in the control group (p = 0.972). The HBO group had significantly higher correct task rates than the control group after the intervention (p = 0.001).ConclusionThis study confirms that long-term high-altitude exposure leads to impairment of CCC in high-altitude newcomers and that hyperbaric oxygen intervention is effective in improving CCC.
Optimizing wheat prosperity: innovative drip irrigation and nitrogen management strategies for enhanced yield and quality of winter wheat in the Huang-Huai-Hai region
Authors: Zhao Jinke , Xu Xuexin , Liu Shuai , Jia Jing , Li Menglan , Huang Hanliu , Zhang Guoqing , Zhao Changxing 
Published: August 2024

IntroductionTo examine the impacts of varied water and nitroge combinations on wheat yield and quality under drip irrigation in the Huang-Huai-Hai area, a field experiment was conducted over two growing seasons of winter wheat from 2019 to 2021.MethodsTraditional irrigation and fertilization methods served as the control (CK), with two nitrogen application rates set: N1 (180 kg/ha) and N2 (210 kg/ha). The irrigation schedules were differentiated by growth stages: jointing, anthesis (S2); jointing, anthesis, and filling (S3); and jointing, booting, anthesis, and filling (S4), at soil depths of 0-10 cm (M1) and 0-20 cm (M2). ResultsResults indicated that compared to CK, the 3 and 4 times irrigation treatments comprehensively improved grain yield (GY) by 8.0% and 13.6% respectively, increased the average plant partial factor productivity of nitrogen fertilizer (PFPN) and irrigation use efficiency (IUE) by 57.5% and 38.2%, and 62.2% and 35.8%, respectively. The gluten content (GC) of 3 irrigations was 1.6% higher than CK, and other metrics such as dough tenacity (DT), softness (ST), water absorption (WAS), and gluten hardness (GH) also showed improvements. Furthermore, the contents of amylose, amylopectin, and total starch under 3 irrigations significantly increased by 9.4%, 11.4%, and 9.8%, respectively, with higher than 4 irrigations. The crude protein content and soluble sugar content in 3 irrigations rose by 6.5% and 9.8% respectively over two years. These irrigation treatments also optimized gelatinization characteristics of grains, such as breakdown viscosity (BDV), consistency peak viscosity (CPV), consistency setback viscosity (CSV), pasting temperature (PeT), and pasting time (PaT).DiscussionThe study demonstrated that appropriate drip irrigation can effectively synchronize water and nitrogen supply during critical growth stages in winter wheat, ensuring robust late-stage development and efficient transfer of photosynthetic products into the grains, thus enhancing grain mass and yield. This also led to improved utilization of water and fertilizer and enhanced the nutritional and processing quality of the grain. However, excessive irrigation did not further improve grain quality. In conclusion, given the goals of saving water and fertilizer, achieving excellent yield, and ensuring high quality, the N1S3M1 treatment is recommended as an effective production management strategy in the Huang-Huai Hai area; N1S3M2 could be considered in years of water scarcity.
Relationships between peak alpha frequency, age, and autistic traits in young children with and without autism spectrum disorder
Authors: Kameya Masafumi , Hirosawa Tetsu , Soma Daiki , Yoshimura Yuko , An Kyung-min , Iwasaki Sumie , Tanaka Sanae , Yaoi Ken , Sano Masuhiko , Miyagishi Yoshiaki , Kikuchi Mitsuru 
Published: August 2024

BackgroundAtypical peak alpha frequency (PAF) has been reported in children with autism spectrum disorder (ASD); however, the relationships between PAF, age, and autistic traits remain unclear. This study was conducted to investigate and compare the resting-state PAF of young children with ASD and their typically developing (TD) peers using magnetoencephalography (MEG).MethodsNineteen children with ASD and 24 TD children, aged 5-7 years, underwent MEG under resting-state conditions. The PAFs in ten brain regions were calculated, and the associations between these findings, age, and autistic traits, measured using the Social Responsiveness Scale (SRS), were examined.ResultsThere were no significant differences in PAF between the children with ASD and the TD children. However, a unique positive association between age and PAF in the cingulate region was observed in the ASD group, suggesting the potential importance of the cingulate regions as a neurophysiological mechanism underlying distinct developmental trajectory of ASD. Furthermore, a higher PAF in the right temporal region was associated with higher SRS scores in TD children, highlighting the potential role of alpha oscillations in social information processing.ConclusionsThis study emphasizes the importance of regional specificity and developmental factors when investigating neurophysiological markers of ASD. The distinct age-related PAF patterns in the cingulate regions of children with ASD and the association between right temporal PAF and autistic traits in TD children provide novel insights into the neurobiological underpinnings of ASD. These findings pave the way for future research on the functional implications of these neurophysiological patterns and their potential as biomarkers of ASD across the lifespan.
A global scoping review of adaptations in nurturing care interventions during the COVID-19 pandemic
Authors: Godoi Lidia , Schenkman Simone , Baumann Ana A. , Bousquat Aylene , Buccini Gabriela 
Published: August 2024

BackgroundDuring the COVID-19 pandemic, children faced a disproportionate burden of malnutrition and poor health outcomes. Nurturing care interventions (NCIs) including actions toward good health, adequate nutrition, responsive care, opportunities for early learning, and security and safety are critical for promoting equity. Due to the need for evidence-based responses and preparedness, we analyzed adaptations in NCIs’ implementation strategies during COVID-19 according to the Framework for Reporting Adaptations and Modifications to Evidence-based Implementation Strategies (FRAME-IS).MethodWe conducted a global scoping review including peer-reviewed and non-peer-reviewed literature. The databases searched were PubMed, Embase, Scopus, BVS, Scielo, and Web of Science. This search was complemented by an extensive examination of relevant websites and an additional internet search via Google Scholar. We extracted and analyzed the data following the seven modules of the FRAME-IS.ResultsOut of 20 records, 27 NCI were identified across Africa (n = 3), Asia (n = 7), Europe (n = 3), North America (n = 11), Oceania (n = 1), and South America (n = 2). NCIs adapted their content (e.g., adding elements), evaluation (e.g., conducting needs assessment), training (e.g., using experts), and context (e.g., setting—shifting from in-person to remote, and population—expanding interventions’ reach). Adaptation goals were to increase acceptability (n = 9, 32.1%), adoption (n = 5, 17.8%), appropriateness (n = 10, 35.7%), feasibility (n = 25, 89.3%), penetration (n = 15, 53.6%), sustainability (n = 23, 82.1%), and fidelity (n = 1, 3.7%). The rationale to adapt varied from sociopolitical (n = 6, 21.4%), organizational (n = 13, 46.4%), implementer (n = 11, 39.3%), practitioner (n = 15, 53.6%), and recipient (n = 11, 39.3%). A quarter were reactive planned adaptations and 75.0% were unplanned modifications. Decisions were led by program leaders (n = 21, 75.0%), funders (n = 9, 32.1%), partners (n = 3, 10.7%), researchers (n = 1, 3.6%), and practitioners (n = 3, 10.7%). Adaptations were widespread from unit (e.g., hospital) (n = 1, 3.6%), organization (n = 4, 14.3%), and community system (e.g., countrywide) (n = 14, 50.0%).ConclusionThe results from our global scoping review show that it is possible for NCIs to continue and even improve their delivery despite the global crisis, suggesting that remote delivery is feasible and can work as an alternative when in lockdown. Strategic planning taking advantage of existing structures and partnerships may have allowed NCI adaptations to be sustainable as well as facilitated replication within the organization network system.
The influence of exercise adherence on peace of mind among Chinese college students: a moderated chain mediation model
Authors: Liu Feiyang , Yu Ping , Wu Jinlong , Guo Liya 
Published: August 2024

IntroductionExercising adherence constitutes a pivotal approach for college students to maintain physical well-being, while peace of mind serves as a crucial indicator of their psychological health. However, few previous studies have delved into the relationship between these two variables. Our study endeavors to investigate the association between the exercise adherence and the peace of mind of college students.MethodsThe Exercise Adherence Questionnaire, Meaning in Life Questionnaire, Brief Self-Control Scale, Peace of Mind Scale, and Self Acceptance Questionnaire were tested on 1,520 college students from four universities in western China, and SPSS 25.0 and Mplus 8.3 were used for analysis.ResultsThe results indicate a significant positive correlation between exercise adherence and meaning in life (r = 0.208, p &lt; 0.001), self-control (r = 0.210, p &lt; 0.001), and peace of mind (r = 0.237, p &lt; 0.001) among college students. Mediation analysis reveals that exercise adherence has a significant direct effect on peace of mind in college students, with an effect size of 0.087. Moreover, meaning in life and self-control independently mediate the relationship between exercise adherence and peace of mind, with mediation effect sizes of 0.046 and 0.052, respectively. Additionally, meaning in life and self-control collectively exhibit a chain mediation effect, with a mediation effect size of 0.032. At the same time, the interaction terms of meaning in life and self-acceptance had a significant predictive effect on self-control (b = 0.090, p = 0.002).ConclusionThis study reveals both the relationship and intrinsic mechanisms by which exercise adherence influences the peace of mind among college students. Exercise adherence demonstrates a direct positive impact on peace of mind. Additionally, the association between exercise adherence and peace of mind is influenced by the individual mediating effects of meaning in life and self-control, as well as the chain mediation effect of meaning in life and self-control. Moreover, self-acceptance plays a positive role in regulating the relationship between meaning in life and self-control in the chain mediated pathway. This suggests that we need to encourage college students to develop the habit of exercise adherence and to carry out public welfare activities to enhance their meaning in life, self-control and self-acceptance, which will effectively promote their mental health.