bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multiple risk factors are associated with an incremental increase in acute venous thromboembolism risk after total joint arthroplasty: A pearldiver cohort study
Authors: Kumar Mandeep , Kostyun Regina O. , Solomito Matthew J. , McClure Mitchell 
Published: August 2024

Introduction
Several risk factors are associated with acute venous thromboembolism (VTE) after total joint arthroplasty (TJA). However, there is a lack of literature regarding the cumulative impact of multiple risk factors. To address this gap, we utilized the PearlDiver database, an insurance billing claims database containing de-identified data from 91 million orthopedic patients.

Methods
The PearlDiver database was queried for records of patients who underwent total hip and knee arthroplasty from 2010 to 2019 using ICD-10 and CPT codes. Twelve persistent and two transient risk factors were analyzed for their association with the occurrence of acute VTE within three months after surgery. Univariate and logistic regression analyses with odds ratios (ORs) and confidence intervals (CIs) were conducted to determine the odds associated with each risk factor and the impact of multiple concurrent risk factors.

Results
A total of 988,675 patients who underwent hip and knee arthroplasty met the inclusion criteria, of whom 1.5% developed acute VTE after three months. The prevalence of VTE risk factors ranged from 0.2 to 38.6%. Individual, persistent risk factors demonstrated 14–84% increased odds of VTE compared to a 1.2% increase for a transient risk factor (acute myocardial infarction). Three or more persistent risk factors were associated with a higher risk of VTE.

Conclusion and relevance
Persistent risk factors were associated with a higher incidence of postoperative VTE than transient risk factors. An incremental increase in risk was noted if three or more persistent risk factors were present.
Desenvolvimento do pensamento algébrico de professores dos anos iniciais no contexto da formação continuada
Authors: Santos Fernanda Cristina Ferreira , Moretti Vanessa Dias 
Published: August 2024

As discussões sobre o ensino da álgebra nos anos iniciais do ensino Fundamental têm sido tema de pesquisas nas últimas décadas e se intensificaram nos últimos anos, sobretudo com a nova Base Nacional Comum Curricular. Investigações relacionadas à formação de professores que ensinam matemática nos anos iniciais tornam-se relevantes na medida em que o professor é o responsável pela organização do ensino, estando diretamente relacionado ao movimento de aprendizagem dos estudantes. Neste artigo, apresentamos o recorte de uma pesquisa, fundamentada na perspectiva Histórico-Cultural, que teve como objetivo investigar o desenvolvimento do pensamento algébrico de professores dos anos iniciais, considerando o pensamento algébrico como o pensamento teórico mediado por conceitos algébricos. Os aspectos metodológicos pautaram-se no materialismo histórico-dialético e a produção de dados se deu por meio de um experimento formativo organizado com base na Atividade Orientadora de Ensino, com Situações Desencadeadoras de Aprendizagem que considerassem o movimento lógico-histórico da álgebra, com vistas à aproximação da essência da álgebra e dos nexos conceituais algébricos. O recorte de análise traz cenas do movimento formativo de uma das professoras participantes do experimento, permitindo a identificação de possíveis superações no modo de a professora definir o que é álgebra, além de sua compreensão sobre a fluência, variação de grandezas, variável e campo de variação, num movimento do geral para particular, isto é, da busca de regras gerais que resolvam as situações particulares. Tais movimentos de aproximação dos nexos conceituais e da essência da álgebra pela professora remetem ao processo de desenvolvimento do pensamento algébrico.
Smart bionanomaterials for treatment and diagnosis of inflammatory bowel disease
Authors: Stojanov Spase , Berlec Aleš 
Published: August 2024

Abstract
Inflammatory bowel disease (IBD) encompasses a group of chronic inflammatory disorders that affect the gastrointestinal tract, with Crohn’s disease and ulcerative colitis being the primary subtypes. Diagnosis and treatment of IBD are challenging due to their unknown etiology and complex pathology. Smart bionanomaterials, which are biocompatible nanometer-sized materials that respond to external stimuli, can be used in the treatment and diagnosis of diseases. In the context of IBD, these materials can deliver drugs, primarily aminosalicylates, and corticosteroids, as well as live probiotics to the inflamed parts of the intestine, with a specific focus on the colon. The controlled release of drugs can be triggered by the conditions present in the IBD-affected intestine, such as inflammation, anaerobic environment, neutral pH, and gut microbiota. This article provides an overview of the use of smart bionanomaterials, including hydrogels, nanoparticles, nanofibers, and hybrid systems. It discusses their manufacturing process and their ability to deliver active ingredients in response to various stimuli, such as pH, temperature, reactive oxygen species, magnetic field, and biomolecules, for the treatment of IBD. We also describe the use of smart probiotics, which have been genetically engineered to recognize specific stimuli and synthesize recombinant proteins for the treatment of IBD. The qualitative or quantitative response to inflammatory stimuli can be exploited in diagnostic applications, with some examples already developed. Smart bionanomaterials offer several advantages, such as encapsulation, targeted delivery, responsiveness to stimuli, and controlled release. These features make them a valuable adjunct tool in the diagnosis and treatment of IBD.
Advancing rheumatic disease treatment: A journey towards better lives
Authors: Rehman Shakil U. , Chopra Vipender Singh , Dar Mohd Altaf , Maqbool Mudasir , Qadrie Zulfkar , Qadir Afshana 
Published: August 2024

Abstract
The field of rheumatic disease treatment has undergone a profound transformation, characterized by significant progress in research, precision medicine, and holistic patient care. Rheumatic diseases, a diverse group of conditions affecting the joints, muscles, bones, and connective tissues, have historically caused pain and disability for millions worldwide. Traditional treatment methods primarily centered on managing symptoms, relying heavily on medications like nonsteroidal anti-inflammatory drugs and corticosteroids. While these approaches provided some relief, they often carried side effects and had limited long-term effectiveness. However, recent years have witnessed remarkable breakthroughs in our understanding and management of rheumatic diseases. Pioneering research has unveiled the complex immunological mechanisms at the core of these disorders, leading to the development of targeted therapies that specifically inhibit key molecules and pathways responsible for inflammation. Biologic medications, such as tumor necrosis factor inhibitors and interleukin-6 inhibitors, have completely transformed treatment paradigms by not only alleviating symptoms but also potentially altering the course of diseases like rheumatoid arthritis (RA). Moreover, precision medicine has emerged as a central pillar of rheumatic disease management, creating personalized treatment strategies based on a patient’s unique genetic, molecular, and immunological profile. Genetic markers, such as the human leukocyte antigen gene, can identify individuals with a heightened risk of developing RA, allowing for proactive interventions that may prevent or mitigate the onset of the disease. Combination therapies, which combine different classes of medications, offer hope for patients who do not respond adequately to single-drug treatments. Beyond pharmaceutical interventions, holistic patient care encompasses lifestyle modifications, physical therapy, occupational therapy, and patient education, all aimed at improving overall well-being. Looking forward, ongoing research, innovation, and collaborative efforts among healthcare professionals, researchers, and patients are essential to sustain the trajectory of progress in rheumatic disease treatment. The future holds the potential for further breakthroughs, poised to reshape the lives and futures of individuals grappling with the complexities of these challenging health conditions, ushering in an era of renewed hope and an improved quality of life.
A Qualitative Analysis of Open-Access Publishing-Related Posts on Twitter
Authors: Okere Oluchi Ojinamma , Onyebinama Colette Ogugua 
Published: August 2024

Abstract
The open-access (OA) discourse is shrouded in controversy and is actively discussed on forums like social media, where scholars engage in professional conversations. The mining of the conversations of the Twitter (X) scholarly community with an open-source intelligence tool for a 7-day time frame yielded a cleaned dataset of 67 posts, which were analyzed and coded into seven major themes. Most Twitter users who participated in the #openaccess discussion were scholars (64%), but (institutions) libraries and publishers, universities, and repositories were also part of the participants in the discourse. The major themes that were identified in the corpus of posts retrieved were article processing charges (25%), repositories (16%), paywalls (15%), support initiatives for OA (15%), definitions of OA (12%), benefits of OA (10%), and OA policies (10%). These themes were found to be of high interest to scholars and in line with contemporary research, based on the volume and tone of the peer-reviewed literature that supports the study. While Twitter (X) can be accepted as an authentic platform for exploring scholarly discourse, such studies can also lean on other forums for scholarly communication such as LinkedIn, Facebook, focus groups, peer-reviewed literature, and institutional policies for a well-rounded exploration of the evolving perspectives and practices of OA publishing.
A Stone that Winnows: Luke 20,18 as a Creative Quotation of Scripture
Authors: Davis Phillip Andrew 
Published: August 2024

Abstract
Critical editions, translations, and scholarly discussions typically treat Luke 20,18 as a separate logion from the preceding quotation from Ps 118 (MT; LXX 117) in Luke 20,17 that ends Jesus’ telling of the parable of the wicked tenants. Despite its separation from the quote, scholars have typically seen in the line allusions to Isa 8,14–15 and Dan 2,34–35.44–45. This article questions both of these usual assumptions, arguing (a) that 20,18 should in fact be read as the second half of the quotation begun in 20,17 and (b) that its language of crushing and in particular “winnowing” (λικμάω) takes up a common scriptural judgment motif. Luke 20,18 represents, then, a point of convergence between explicit quotation and the third gospel’s frequent use of septuagintal language that results in a creative proof-text.
“For a Little While Lower than the Angels” (Ps 8,6): Humanity’s Temporary Inferiority in Hebrews 2,7
Authors: Greene Judson D. 
Published: August 2024

Abstract
Some argue that Hebrews employs Psalm 8,6a—“You made him for a little while below the angels”—to serve the divergent ends of describing Jesus’ degradation and humanity’s exaltation. Against this view, this article argues that Hebrews applies these words more analogously to describe a temporary inferior status below angels for both Jesus and humanity, a status Jesus has already surpassed and humanity will rise above in the future. To make this argument, this article defends that Hebrews applies Psalm 8 to both Jesus and humanity. After examining the application to Jesus, it is argued that Hebrews presents humanity as presently lower than angels, but indicates they will attain a rank above them in the future. Finally, the article claims that the word ἐλαττόω means “to diminish,” not “to create at a lesser status.” Thus, Hebrews may understand the statement that God “diminished humanity below angels” as a reference to God’s judgment on humanity’s first sin.
“Do Not Weep for Me, but Weep for Yourselves”: Luke 23,27–31 and Plato’s
Phaedo
117c
Authors: Kozlowski Jan M. 
Published: August 2024

Abstract
Scholars have long recognized significant similarities between Plato’s Phaedo and the Gospel of Luke. However, the absence of convincing evidence confirming that Luke was acquainted with Phaedo has prevented scholars from asserting that he drew directly from Plato’s dialogue. Notably, previously overlooked are the remarkable resemblances between the narratives of Luke 23,27–33 and Phaedo 117c. The most straightforward explanation for these similarities is the direct influence of Plato’s narrative on the Lukan text.
Praca socjalna z rodziną
Authors: Zając Daniel 
Published: August 2024

Cel. Celem artykułu jest rzetelne studium literatury naukowej poświęconej pracy socjalnej z rodziną i deskrypcja oraz scalenie wybranych treści i ram teoretycznych w koherentną całość w związku z podjęciem się wybranego tematu
Omówione koncepcje. Artykuł traktuje w sposób przeglądowy o wybranej problematyce. Na kanwie dotychczasowych doniesień naukowych oraz regulacji prawnych dotyczących pracy socjalnej z rodziną. Artykuł ilustruje jej merytoryczną zasadność i ulokowaną w teorii istotę działań pomocowych. Ponadto praca przedstawia jej ujęcia oraz wskazuje na wybrane rozwiązania i modele pracy z rodziną. Tekst również pochyla się nad materią definicyjną pracy socjalnej oraz rodziny i jej problemów.
Wyniki i wnioski. Treść pracy akcentuje wartość i zasadność implementacji rozwiązań systemowych zawartych w działalności zawodowej pracy socjalnej na rzecz rodzin i ich członków. Artykuł uwypukla oraz spaja materię teoretyczną oraz praktyczną wybranych treści oraz kumuluje ich doniesienia w formie wniosków i opisów zagadnień. Tak więc artykuł stanowi o merytorycznej zasadności i skuteczności działań pomocowych, jak również przybliża i omawia wiążące dla tematu koncepcje i modele pracy socjalnej z rodziną.
Wartość poznawcza. W artykule zaprezentowano kompleksowe zestawienie teorii oscylujących wokół materii definicyjnej pracy socjalnej i rodziny. Ponadto praca podejmuje się eksplikacji przesłanek świadczących o zasadności wdrażania rozwiązań i działań pracy socjalnej na rzecz rodzin. Co więcej, tekst także opisuje i przybliża ujęcia oraz modele pracy socjalnej z rodziną poprzez przytoczenie wybranych praktyk i ich podstaw teoretycznych. Jest to zatem tekst akcentujący teoretyczno-praktyczny charakter i formę pracy socjalnej z rodziną. W rezultacie służy on uwypukleniu rzeczonej tematyki oraz stanowić może również punkt odniesienia dla większej dyskusji w ramach poruszonej problematyki.
HYPERSENSITIVITY VASCULITIS WITH ACUTE NEPHRITIC SYNDROME DURING SEVERE CO-INFECTION
Authors: Е. Kostadinova  , V. Tzaneva  
Published: August 2024

Many pathogenic microorganisms can induce a complex series of immunologic, endothelial-cell and cascades activation and dysfunctions. These events induce the development of hypersensitivity vasculitis. Case report: We report the case of 13 years-old girl with hypersensitivity vasculitis, which developed during the course of a mixed infection with beta-hemolytic streptococcus and EBV infection. A month before hospitalization the girl had two episodes of purulent tonsillitis for which she received antibiotic treatment. After a week period without complains she is presented again with high temperature, chills, photophobia, insomnia, muscle pains, maculopapular rash that involves the body and suppurative tonsillitis. In the next days haemorrhagic macules, papules and patches appeared on the face, neck, legs, billateral conjunctival ecchymosis, epistaxis and tonsillar hemorrhage. The medical condition manifests with deteriorated condition of the child, septic fever, generalized lymphadenopathy and hepatosplenomegaly. The clinical presentation is enriched with symptoms of acute nephritic syndrome. There is a history of several tick bites and contact with dogs, without clinical evidence for Erythema migrans. Conclusions: This case is a demonstration of a severe clinical course of Hypersensitivity vasculitis with acute nephritic syndrome as a result of the identified co-infection beta-hemolytic streptococcus and EBV infection. The clinical course is due to the development of complicated pathogenic and immunologic mechanisms. The positive serology for B. Burgdorferi without the presentation of the specific symptoms of Lyme disease is due to cross reaction. Long-term clinical and laboratory follow-up showed complete recovery.
BIM based collision tracking at the intersections of different building engineering systems at the design stage
Authors: Pogorelskiy Sergey , Kocsis Imre 
Published: August 2024

AbstractReduction of design errors, minimisation of rework and the improvement of the design productivity are key factors in building engineering systems (including structural and architectural solutions, ventilation systems, sewerage systems, water supply and heating systems, power supply systems, and communication networks). These goals can be achieved with a complex approach that prioritises the design of different building engineering systems in the model during the design phase, in order to provide a consistent design for different building engineering systems. The paper presents a novel approach for the application of plugins in building service systems with the elimination of collision in the focus. Collision reduction actions in this methodology are categorised into three levels: the code level, which pertains to plugin developers; the algorithm level, which relates to BIM coordinators; and the user level, which concerns engineers performing the check. This new systematic approach to collision resolution prioritises maintaining the consistency of collision detection across different systems and storing all information about each collision. Collision checking is based on several key factors, such as complying with the sequence of checking systems, excluding irrelevant collisions, and setting tolerances when joining system elements. The aim of our approach is to automate and expedite not only the identification of the intersections but also the subsequent work with it throughout the entire project life cycle. The results are demonstrated by a case study conducted in the frame of a real project.
Tales of mice and men: Natural History of Arenaviruses
Authors: Rodas G. Juan David , Salvato Maria S. 
Published: August 2024

Summary
Nowadays, Arenaviruses are among the most feared viruses due to their potential as weapons for bioterrorism purposes. This potential is based on their increasing diversity and the fact that they are carried by rodentswhose biologic success compares only wit insects and humans. The prototype of this family is Lymphocytic Choriomeningitis Virus which has been and excellent tool for a myriad of discoveries in immunology. Arenaviruses have been known for over 70 years but the number of members of the family is growing thanks to their insidious subsistence in third world countries and to the nature of their genome, that makes of them sorts of skilful machines for evolution This review collects some of the work of the authors about the best-known features described for this group of viruses, among the many still-to-be discovered characteristics of this puzzling, and hard-to-study, group of zoonotic viruses.
Resumen
En la actualidad, los arenavirus son considerados uno de los grupos de virus más temidos debido a su potencial uso como armas para el bio-terrorismo, debido a su diversidad creciente y a que son portados por roedores, cuyo éxito para sobrevivir, y adaptarse, solo puede compararse con el de los mosquitos y los seres humanos. El prototipo de esta familia viral, el virus de la coriomeningitis linfocítica, ha servido como herramienta para una gran cantidad de descubrimientos sobre la respuesta inmune. Los arenavirus han sido conocidos por más de 70 años, pero la familia aún sigue creciendo, gracias a su subsistencia insidiosa en los países del tercer mundo, y a su naturaleza genética, que les permite comportarse como máquinas "habilidosas" para la evolución. Esta revisión, recoge algunos de los resultados de los autores sobre los rasgos mejor conocidos, entre los muchos que aún no han sido descubiertos en grupo de virus zoonóticos, intrigante y muy difíciles de estudiar.
El espermatozoide, desde la eyaculación hasta la fertilización
Authors: Olivera A. Martha , Ruíz Tatiana , Tarazona Ariel M. , Giraldo Carlos A. 
Published: August 2024

Resumen
En los últimos años se ha hecho un inmenso progreso en el entendimiento de los mecanismos moleculares involucrados en la maduración del gameto masculino y su tránsito desde la gónada hasta la fertilización del oocito. A lo largo de este trayecto el espermatozoide modifica su morfología y sus componentes moleculares especialmente, y además ocurren procesos que conducen a la activación para la entrada al oocito, para activar a su vez los mecanismos que conducen a la formación del zigoto. Este artículo presenta, a partir de la interpretación de la literatura actual un modelo de los eventos que se suceden a partir de la eyaculación hasta la fertilización, con énfasis en los mecanismos celulares y moleculares conocidos, y señala algunos vacíos de información aún existentes.
Palabras clave: activación, adhesión, capacitación, fusión, reacción acrosomal.
Summary
During the last recent years there has been a great increase of information regarding the molecular mechanisms involved in the maturation of the male gamete as well as its progression from the gonad up to fertilizing the oocyte. Along this way the sperm completes its maturation adding some molecular components; additionally along this trail take place all the processes leading to activation of the sperm for the entrance into the oocyte to initiates molecular cascades for the formation of a zygote. This article, based on updated literature proposes a model that integrates known cellular and molecular interactions and pinpoints some steps still requiring further research.
Manifeste: Navire Avenir / Vessel of the Future: Manifesto
Authors: Collectif du Navire Avenir  
Published: August 2024

Le Navire Avenir est un outil pionnier de sauvetage et de soin en haute mer, premier bâtiment d'une flotte mondiale. C’est un « Ready-made pour le 21e siècle », une œuvre agissante conçue pour soutenir l'action des marins sauveteurs et contribuer à leur reconnaissance au Patrimoine culturel immatériel de l'humanité. « Comme toutes les œuvres d’art », écrit le collectif dans son manifeste, le projet « vise non seulement à changer notre vision du monde mais aussi à changer le monde lui-même ». Le manifeste complet suit, avec des illustrations du processus de création développé depuis 4 ans en Europe. Cette oeuvre doit encore être réalisée avec le soutien financier des citoyennes et citoyens notamment, via la plateforme www.navireavenir.eu.
The Navire Avenir is a pioneering tool for rescue and care on the high seas, the first vessel in a worldwide fleet. It is “Ready-made for the 21st century”, a proactive work designed to support the actions of rescue sailors and contribute to their recognition as part of the Intangible Cultural Heritage of Humanity. “Like all works of art”, writes the collective in its manifesto, the project "aims not only to change our vision of the world, but also to change the world itself". The full manifesto follows, with illustrations of the creative process developed over the past four years in Europe. This work is yet to be realized with the financial support of citizens, notably via the www.navireavenir.eu platform.