bluuebunny/crossref_metadata_2025_split huggingface dataset:
Short and Medium Term Oncological Results after Robot-Assisted Prostatectomy: A Comparative Prospective Non Randomized Study
Authors: Gatti Lorenzo , Antonelli Alessandro , Gritti Alberto , Finamanti Marco , Peroni Angelo , Simeone Claudio 
Published: March 2013

Background Our aim was to compare both the perioperative and the short/medium-term post-operative oncological results after radical prostatectomy between two groups of prostate cancer patients: one group treated with radical retropubic prostatectomy (RRP), the other one with robot-assisted laparoscopic prostatectomy (RALP). Methods We collected all the clinical, surgical, pathological and follow-up data of the patients who underwent radical prostatectomy with the two different surgical methods in a dedicated database. The positive surgical margins were defined by the presence of disease at the resection margin marked with China ink. The biochemical persistence of disease was defined as a PSA value >0.1 ng/mL 30 days after surgery, while the biochemical recurrence of the neoplasia was defined as a PSA value >0.2 ng/mL. Results The positive surgical margins (PSM) were identified as follows: 29.3% (RRP) versus 25.4% (RALP) in pT2 cancer (p 0.563), and 63.6% (RRP) versus 50.0% (RALP) in case of >pT2 cancer (p 0.559). If stratified by surgical approach, the results are: 53.3% (RRP) versus 25.6% (RALP) (p <0.001) in case of nerve-sparing technique. The persistence of disease is detectable in 5.4% (RRP) versus 4.6% (RALP), while the data on biochemical recurrence are: 2.7% (RRP) versus 0% (RALP). Conclusions In our experience, in two groups of patients matched for clinic-pathological features who underwent RRP and RALP, oncological results are slightly better in the second group; this figure is even more significant when evaluating surgeries conducted with nerve-sparing technique. In this study we analyzed data of RALP, recently introduced in our center, comparing with RRP, a surgical technique consolidated through the decades. Therefore it can be said that even during the learning curve, RALP provides oncological results comparable to RRP.
Retracted: Recellularization of Acellular Human Small Intestine Using Bone Marrow Stem Cells
Authors: Patil Pradeep B. , Chougule Priti B. , Kumar Vijay K. , Almström Stefan , Bäckdahl Henrik , Banerjee Debashish , Herlenius Gustaf , Olausson Michael , Sumitran-Holgersson Suchitra 
Published: March 2013

Abstract
We aimed to produce an acellular human tissue scaffold with a view to test the possibility of recellularization with bone marrow stem cells to produce a tissue-engineered small intestine (TESI). Human small-bowel specimens (n = 5) were obtained from cadaveric organ donors and treated sequentially with 6% dimethyl sulfoxide in hypotonic buffer, 1% Triton X-100, and DNase. Each small intestine (SI) piece (6 cm) was recellularized with EPCAM+ and CD133+ allogeneic bone marrow stem cells. Histological and molecular analysis demonstrated that after decellularization, all cellular components and nuclear material were removed. Our analysis also showed that the decellularized human SI tissue retained its histoarchitecture with intact villi and major structural proteins. Protein films of common extracellular matrix constituents (collagen I, laminin, and fibronectin) were found in abundance. Furthermore, several residual angiogenic factors were found in the decellularized SI. Following recellularization, we found viable mucin-positive goblet cells, CK18+ epithelial cells in villi adjacent to a muscularis mucosa with α-actin+ smooth muscle cells, and a high repopulation of blood vessels with CD31+ endothelial cells. Our results show that in the future, such a TESI would be ideal for clinical purposes, because it can be derived from the recipient's own immunocompatible bone marrow cells, thus avoiding the use of immunosuppression.
Concise Review: Adult Mesenchymal Stem Cells, Adult Neural Crest Stem Cells, and Therapy of Neurological Pathologies: A State of Play
Authors: Neirinckx Virginie , Coste Cécile , Rogister Bernard , Wislet-Gendebien Sabine 
Published: March 2013

AbstractAdult stem cells are endowed with in vitro multilineage differentiation abilities and constitute an attractive autologous source of material for cell therapy in neurological disorders. With regard to lately published results, the ability of adult mesenchymal stem cells (MSCs) and neural crest stem cells (NCSCs) to integrate and differentiate into neurons once inside the central nervous system (CNS) is currently questioned. For this review, we collected exhaustive data on MSC/NCSC neural differentiation in vitro. We then analyzed preclinical cell therapy experiments in different models for neurological diseases and concluded that neural differentiation is probably not the leading property of adult MSCs and NCSCs concerning neurological pathology management. A fine analysis of the molecules that are secreted by MSCs and NCSCs would definitely be of significant interest regarding their important contribution to the clinical and pathological recovery after CNS lesions.
Educational Needs Among Pediatricians Regarding Caring for Terminally Ill Children
Authors: Khaneja Seema , Milrod Barbara 
Published: March 2013

BackgroundAccording to the Accreditation Council on Graduate Medical Education and the Ambulatory Pediatrics Association, pediatricians need to be instructed in caring for terminally ill children as a part of residency training. However, a systematic approach to education in end-of-life care is lacking in most residency programs.ObjectivesTo assess pediatricians' self-perception of their coping skills regarding death and dying at The New York Hospital–Cornell Medical Center, New York City, NY, if they felt further support and education were needed in this area, and which modes of instruction respondents thought would be most useful.MethodsData based on a questionnaire distributed to pediatricians at The New York Hospital are presented.ResultsThe following topics are discussed: (1) existing level of education and support in caring for terminally ill patients; (2) attitudes of pediatricians regarding discussions of diagnosis and prognosis with dying children and their families; (3) pediatricians' perceived need to limit emotional involvement with terminally ill children; (4) attendance of funeral or memorial services of patients by pediatricians; (5) experience of patient death as a failure; and (6) expressed need for support and instruction in death and dying based on level of training.ConclusionEducational interventions and support in this area are needed.
Indian Psychology
Authors: Salagame Kiran Kumar K. 
Published: March 2013

AbstractIndian psychology is a twentieth‐century phenomenon, though its roots go back to the Vedic period of the Indian sub‐continent in Asia (originally known as Bhaarata), the exact date of which is still under debate. According to current historical reckoning, the Vedic period dates from about 3000bce, although some Western scholars date it back to 10,000bce, based on recent excavations in the site of the Indus Valley Civilization. Though psychology, unlike astronomy, medicine, economics, law and polity, or literature, was not recognized as an independent branch of study in ancient India, there has been no dearth of psychological theorizing scattered in varied sources, including mythology and epics, literary texts, linguistics, texts on dramatics, sexology, medicine, philosophy, religion, and spirituality. Concepts and models related to almost all aspects of human behavior, such as cognition, affect, and conation, can be found in these sources, especially those human potentials which are yet to find their way into mainstream psychology, such as intuition, paranormal phenomena, altered states of consciousness, and transcendent awareness or pure consciousness. These topics are found not only in texts and treatises related to Vedic tradition but also in non‐Vedic traditions such as Jainism and Buddhism. Yet no efforts at collecting and systematizing a vast body of psychological knowledge are evident until the beginning of the twentieth century.
Third Party Involvement in Barroom Conflicts
Authors: Parks Michael J. , Osgood D. Wayne , Felson Richard B. , Wells Samantha , Graham Kathryn 
Published: March 2013

AbstractThis study examines the effect of situational variables on whether third parties intervene in conflicts in barroom settings, and whether they are aggressive or not when they intervene. Based on research on bystander intervention in emergencies, we hypothesized that third parties would be most likely to become involved in incidents with features that convey greater danger of serious harm. The situational variables indicative of danger were severity of aggression, whether the aggression was one‐sided or mutual, gender, and level of intoxication of the initial participants in the conflict. Analyses consist of cross‐tabulations and three‐level Hierarchical Logistic Models (with bar, evening, and incidents as levels) for 860 incidents of verbal and physical aggression from 503 nights of observation in 87 large bars and clubs in Toronto, Canada. Third party involvement was more likely during incidents in which: (1) the aggression was more severe; (2) the aggression was mutual (vs. one‐sided) aggression; (3) only males (vs. mixed gender) were involved; and (4) participants were more intoxicated. These incident characteristics were stronger predictors of non‐aggressive third party involvement than aggressive third party involvement. The findings suggest that third parties are indeed responding to the perceived danger of serious harm. Improving our knowledge about this aspect of aggressive incidents is valuable for developing prevention and intervention approaches designed to reduce aggression in bars and other locations. Aggr. Behav. 39:257–268, 2013. © 2013 Wiley Periodicals, Inc.
Egocentric versus Allocentric Spatial Ability in Dentistry and Haptic Virtual Reality Training
Authors: Kozhevnikov Maria , Schloerb David W. , Blazhenkova Olesya , Koo Samuel , Karimbux Nadeem , Donoff R. Bruce , Salcedo Jairo 
Published: March 2013

SummaryThe current study investigates the role of egocentric and allocentric spatial abilities in the field of dentistry. Whereas allocentric ability requires spatial transformation from a stationary point of reference, egocentric spatial ability is tied to the sensory‐motor system, and it requires changing one's imagined perspective in space. Experiment 1 investigates the role of different spatial abilities in a tooth preparation exercise. Experiment 2 investigates the interaction of allocentric and egocentric spatial abilities with the effectiveness of haptic virtual reality training. The results show that only egocentric spatial ability was a significant predictor of success in tooth preparation. In addition, an egocentric spatial ability test was the reliable predictor of success in more complex (indirect vision) tasks during haptic virtual reality training. Our results indicate the need for the development of finer measures of the specific spatial skills that might be needed for different dental specializations. Copyright © 2013 John Wiley & Sons, Ltd.
Attention and Memory for Newspaper Advertisements: Effects of Ad–Editorial Congruency and Location
Authors: Simola Jaana , Kivikangas Markus , Kuisma Jarmo , Krause Christina M. 
Published: March 2013

SummaryPrevious research suggests that the same ad can have different effects depending upon the media context in which the ad appears. This experiment investigated how the semantic relation between the content of advertisements and editorial texts, and the ad location on newspaper pages affect attention and memory for advertisements. We recorded participants' eye movements while they read newspaper articles to rate how interesting the texts were. Recognition for ads, logos, and editorial headlines was measured on the following day. Results revealed a discrepancy between attention and memory results, suggesting that incongruency increased attention to ads, whereas congruency improved recognition of ads. In addition, ads presented on the right attracted more attention and were recognized better than ads on the left. The results have implications for pretesting of advertisements, because attention and memory for ads were associated with higher preference for brands, and purchase intention was enhanced for the brands that were recognized. Copyright © 2013 John Wiley & Sons, Ltd.
Fault detection filter design for discrete‐time switched linear systems with mode‐dependent average dwell‐time
Authors: Li Jian , Yang Guang‐Hong 
Published: March 2013

SUMMARYThis paper is concerned with the problem of the fault detection (FD) filter design for discrete‐time switched linear systems with mode‐dependent average dwell‐time. The switching law is mode‐dependent and each subsystem has its own average dwell‐time. The FD filters are designed such that the augmented switched systems are asymptotically stable, and the residual signal generated by the filters achieves a weighted l2‐gain for some disturbances and guarantees an H −  performance for the fault. By the aid of multiple Lyapunov functions combined with projection lemma, sufficient conditions for the design of the FD filters are formulated by linear matrix inequalities, furthermore, the filters gains are characterized in terms of the solution of a convex optimization problem. Finally, an application to boost convertor is given to illustrate the effectiveness and the applicability of the proposed design method. Copyright © 2013 John Wiley & Sons, Ltd.
Realising the Architectural Idea: Computational Design at Herzog & De Meuron
Authors: Peters Brady 
Published: March 2013

AbstractKai Strehlke heads up the Digital Technology Group at Herzog & de Meuron, a team of 12 based in the firm's Basle office. Herzog & de Meuron is a practice that is all about the architecture. However, how does technology interact with design in a practice that is all about the architectural concept? Guest‐editor Brady Peters puts this question to Strehlke, revealing an approach that is all about finding the right tool and some very artful scripting to make the concept work.
Kangaroo: Form Finding with Computational Physics
Authors: Piker Daniel 
Published: March 2013

AbstractA trained architect, who works with the Specialist Modelling Group (SMG) at Foster + Partners, Daniel Piker is also the developer of the Kangaroo plug‐in for Rhinoceros® and Grasshopper®. He explains how Kangaroo has been devised to simulate aspects of the behaviour of real‐world materials and objects in order to modify designs in response to engineering analyses, engendering an intuitive sense of the material world.
Pachyderm Acoustical Simulation: Towards Open‐Source Sound Analysis
Authors: van der Harten Arthur 
Published: March 2013

AbstractThe creator of the Pachyderm Acoustical Simulation plug‐in, Arthur van der Harten is an acoustician working in the Specialist Modelling Group (SMG) at Foster + Partners. Here he describes the flexible format of this plug‐in and how open‐source software aided the analysis of a negative distortion in the acoustics of Hamer Hall Arts Centre in Melbourne.
Fused Thiophene Semiconductors: Crystal Structure–Film Microstructure Transistor Performance Correlations
Authors: Youn Jangdae , Kewalramani Sumit , Emery Jonathan D. , Shi Yanrong , Zhang Shiming , Chang Hsiu‐Chieh , Liang You‐jhih , Yeh Chia‐Ming , Feng Chieh‐Yuan , Huang Hui , Stern Charlotte , Chen Liang‐Hsiang , Ho Jia‐Chong , Chen Ming‐Chou , Bedzyk Michael J. , Facchetti Antonio , Marks Tobin J. 
Published: March 2013

AbstractThe molecular packing motifs within crystalline domains should be a key determinant of charge transport in thin‐film transistors (TFTs) based on small organic molecules. Despite this implied importance, detailed information about molecular organization in polycrystalline thin films is not available for the vast majority of molecular organic semiconductors. Considering the potential of fused thiophenes as environmentally stable, high‐performance semiconductors, it is therefore of interest to investigate their thin film microstructures in relation to the single crystal molecular packing and OTFT performance. Here, the molecular packing motifs of several new benzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (BTDT) derivatives are studied both in bulk 3D crystals and as thin films by single crystal diffraction and grazing incidence wide angle X‐ray scattering (GIWAXS), respectively. The results show that the BTDT derivative thin films can have significantly different molecular packing from their bulk crystals. For phenylbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (P‐BTDT), 2‐biphenylbenzo[d,d′]thieno‐[3,2‐b;4,5‐b′]dithiophene (Bp‐BTDT), 2‐naphthalenylbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (Np‐BTDT), and bisbenzo[d,d′]thieno[3,2‐b;4,5‐b′]dithiophene (BBTDT), two lattices co‐exist, and are significantly strained versus their single crystal forms. For P‐BTDT, the dominance of the more strained lattice relative to the bulk‐like lattice likely explains the high carrier mobility. In contrast, poor crystallinity and surface coverage at the dielectric/substrate interface explains the marginal OTFT performance of seemingly similar PF‐BTDT films.
Dimeric Gold Nanoparticle Assemblies as Tags for SERS‐Based Cancer Detection
Authors: Indrasekara A. Swarnapali D. S. , Paladini Bryan J. , Naczynski Dominik J. , Starovoytov Valentin , Moghe Prabhas V. , Fabris Laura 
Published: March 2013

AbstractHerein, a new class of multifunctional materials combining a clustered nanoparticle‐based probe is presented for surface enhanced Raman scattering (SERS)‐based microscopy and surface functionalization for tissue targeting. Controlled assembly of spherical gold nanoparticles into dimers (DNP‐REP) is engineered using a small, rigid Raman‐active dithiolated linking reporter (REP) to yield narrow internanoparticle gaps and to strategically generate the “hot spot” while concurrently placing the reporter within the region of highest SERS enhancement. Peptide functionalized DNP‐REP materials are highly stable even upon incubation with living cells and show controlled levels of binding and intracellular endocytosis. To demonstrate the functionality of such probes for disease detection, differentially targeted DNP‐REPs are incubated over various time points with cultured human glioblastoma cells. Using human glioblastoma cells, the SERS maps of targeted tumor cells show the markedly enhanced signals of the DNP‐REP, compared to conventional confocal fluorescence based approaches, especially at low incubation times. Even with as few as 40 internalized DNP‐REP, a relatively intense SERS signal is measured, demonstrating the high signal to noise ratio and inherent biocompatibility of the materials. Thus, these Raman reporter‐based nanoparticle cluster probes present a promising and versatile optical imaging tool for fast, reliable, selective, and ultrasensitive tissue targeting and disease detection and screening.
Apparent Germline Mosaicism for a Novel 19p13.13 Deletion Disrupting NFIX and CACNA1A
Authors: Nimmakayalu Manjunath , Horton V. Kim , Darbro Ben , Patil Shivanand R. , Alsayouf Hamza , Keppler‐Noreuil Kim , Shchelochkov Oleg A. 
Published: March 2013

AbstractWe report on a case of apparent germline mosaicism in a family of two sisters carrying a novel 19p13.13 deletion. The 11‐year‐old proposita was referred for evaluation of macrocephaly, moderate intellectual disability (ID), and episodic ataxia. Array comparative genomic hybridization (CGH) detected a 399 kb microdeletion with breakpoints within genes NFIX and CACNA1A. A similar deletion was also seen in the elder sibling who presented with macrocephaly, ID, and strabismus. The deletions were confirmed to be de novo after the parental aCGH analysis suggesting that this is an example of germinal mosaicism. This study contributes additional information for the newly identified 19p13 deletion syndrome and clarifies the clinical roles of genes in the involved region. This case of apparent germline mosaicism represents the only known family in the cohort of 1,800 patients analyzed by our group. © 2013 Wiley Periodicals, Inc.
Epidemiology of hereditary sensory and autonomic neuropathy type IV and V in Japan
Authors: Haga Nobuhiko , Kubota Masaya , Miwa Zenzo 
Published: March 2013

AbstractHereditary sensory and autonomic neuropathy (HASN) refers to a group of rare congenital disorders characterized by loss of pain sensation and other sensory or autonomic abnormalities. Among them, a relatively large proportion of patients with HSAN type IV, which is accompanied by anhidrosis and intellectual disability, are reported from Israel and Japan. HSAN type V, with normal sweating and mental development, is rarely reported in Japan. In 2009, we founded a research group for congenital insensitivity to pain and performed the first epidemiological survey of HSAN types IV and V in Japan. Questionnaires were sent to a total of 3,488 certified training institutions of five nationwide medical societies comprising pediatricians, neurologists, orthopedic surgeons, and dentists. Answers were obtained from 1,610 institutions, and 192 HSAN patients (152 with type IV and 28 with type V) were reported from 105 institutions. After excluding duplicated patients, we identified a total of 62 current, 36 past, and five deceased patients for HSAN‐IV, and a total of 14 current, 13 past, and 0 deceased patients for HSAN‐V. Using these figures, we estimated that the number of Japanese patients with HSAN types IV and V as 130–210 and 30–60 patients, respectively. We identified no gender differences, and patients with a family history of the disorder were limited to affected siblings in both conditions. Most patients with HSAN‐IV were 5–40 years of age, whereas half of the patients with HSAN‐V were 40 years or older. © 2013 Wiley Periodicals, Inc.
Relationship of Bone Mineral Density to Progression of Knee Osteoarthritis
Authors: Lee Ji Y. , Harvey William F. , Price Lori L. , Paulus Jessica K. , Dawson‐Hughes Bess , McAlindon Timothy E. 
Published: March 2013

ObjectiveTo evaluate the longitudinal relationship between bone mineral density (BMD) and BMD changes and the progression of knee osteoarthritis (OA), as measured by cartilage outcomes.MethodsWe used observational cohort data from the Vitamin D for Knee Osteoarthritis trial. Bilateral femoral neck BMD values as well as knee magnetic resonance imaging (MRI) scans in each subject were obtained at baseline and subsequently at 12 months and 24 months. The change in total cartilage volume and tibial and femoral cartilage thickness was measured by manual cartilage segmentation of 2 sequential knee MRI scans in each subject. Multivariable linear regression models were used to examine the associations of baseline BMD and BMD change with the cartilage outcomes, adjusting for baseline age, sex, body mass index, malalignment, and vitamin D treatment. Model fit and assumptions were validated.ResultsA total of 127 subjects were eligible for analysis. Longitudinal BMD loss was associated with loss of cartilage volume (β = 1.25 per 0.1 gm/cm2, P = 0.02) and loss of tibial cartilage thickness (β = 0.028, P = 0.03). BMD loss of a magnitude greater than the least significant change (<−4.7%) was associated with 1.02% cartilage volume loss per year (P = 0.005), 0.014 mm femoral cartilage thickness loss (P = 0.04), and 0.021 mm tibial cartilage thickness loss per year (P = 0.009). There were no significant associations between baseline BMD and any of the cartilage outcomes.ConclusionLongitudinal BMD loss is associated with progressive cartilage loss in knees with OA. Further work to clarify the basis of this relationship could reveal novel therapeutic targets for knee OA.