bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mild Cognitive Impairment and Suicidal Ideation Among Adults Aged 65 Years or Older From Low- and Middle-Income Countries
Authors: Smith Lee , López Sánchez Guillermo Felipe , Soysal Pinar , Veronese Nicola , Jacob Louis , Kostev Karel , Rahmati Masoud , Barnett Yvonne , Keyes Helen , Gibson Poppy , Butler Laurie , Shin Jae Il , Koyanagi Ai 
Published: July 2024

Abstract

Objectives
Mild cognitive impairment (MCI) is a unique indicator of underlying distress that may be strongly associated with suicide risk. Despite this, to date, no study has examined the association between MCI and suicidal ideation. Therefore, the present study aimed to examine the association between MCI and suicidal ideation among adults aged ≥65 years from 6 low- and middle-income countries (LMICs; China, Ghana, India, Mexico, Russia, and South Africa).

Methods
Cross-sectional, nationally representative data from the World Health Organization’s Study on Global Ageing and Adult Health were analyzed. MCI was defined using the National Institute on Aging-Alzheimer’s Association criteria. Self-reported information on past 12-month suicidal ideation was collected. Multivariable logistic regression and meta-analysis were conducted to assess associations.

Results
Data on 13,623 individuals aged ≥65 years were analyzed. The prevalence of suicidal ideation ranged from 0.5% in China to 6.0% in India, whereas the range of the prevalence of MCI was 9.7% (Ghana) to 26.4% (China). After adjustment for potential confounders, MCI was significantly associated with 1.66 (95% confidence interval [95% CI] = 1.12–2.46) times higher odds for suicidal ideation.

Discussion
Mild cognitive impairment was significantly associated with higher odds for suicidal ideation among older adults in LMICs. Future longitudinal studies from LMICs are necessary to assess whether MCI is a risk factor for suicidal ideation.
Navigating normalcy: designing personal health visualizations for pediatric kidney transplant recipients and caregivers
Authors: Jeffs Lily V , Dunbar Julia C , Syed Sanaa , Ng Chelsea , Pollack Ari H 
Published: July 2024

Abstract

Objectives
Patients with chronic illnesses, including kidney disease, consider their sense of normalcy when evaluating their health. Although this concept is a key indicator of their self-determined well-being, they struggle to understand if their experience is typical. To address this challenge, we set out to explore how to design personal health visualizations that aid participants in better understanding their experiences post-transplant, identifying barriers to normalcy, and achieving their desired medical outcomes.

Materials and Methods
Pediatric kidney transplant patients and their caregivers participated in three asynchronous design sessions involving sharing experiences, presenting symbolic objects, and providing feedback on visualizations to understand their perceptions of normalcy post-transplant. Data analysis of design session 1 and 2 comprised deductive and inductive analysis. We used affinity diagramming to identify thematic areas about participants’ transplant experiences. Comprehension of design session three normalcy visualizations was also evaluated.

Results
Participants effectively engaged in the design sessions, revealing diverse perspectives on their experiences. We found there is a significant need for visualizations that depict normalcy to better inform patients and caregivers about their health.

Discussion
Normalcy Visualizations should incorporate three key design principles: personal values, facilitating peer and self-comparison, and seamlessly communicating abstract concepts to help youth kidney transplant recipients comprehend and contextualize if their transplant experience is normal and what normalcy means to them.

Conclusion
By incorporating holistic aspects of patients’ and caregivers’ lives into personal health visualizations, they can be cognizant of their progress to normalcy and empowered to make decisions that help them feel normal.
Quantitative trait loci concentrate in specific regions of the Mexican cavefish genome and reveal key candidate genes for cave-associated evolution
Authors: Wiese Jonathan , Richards Emilie , Kowalko Johanna E , McGaugh Suzanne E 
Published: July 2024

Abstract
A major goal of modern biology is connecting phenotype with its underlying genetic basis. The Mexican cavefish (Astyanax mexicanus), a characin fish species comprised of a surface ecotype and a cave-derived ecotype, is well suited as a model to study the genetic mechanisms underlying adaptation to extreme environments. Here, we map 206 previously published quantitative trait loci (QTL) for cave-derived traits in A. mexicanus to the newest version of the surface fish genome assembly, AstMex3. These analyses revealed that QTL clusters in the genome more than expected by chance, and this clustering is not explained by the distribution of genes in the genome. To investigate whether certain characteristics of the genome facilitate phenotypic evolution, we tested whether genomic characteristics associated with increased opportunities for mutation, such as highly mutagenic CpG sites, are reliable predictors of the sites of trait evolution but did not find any significant trends. Finally, we combined the QTL map with previously collected expression and selection data to identify 36 candidate genes that may underlie the repeated evolution of cave phenotypes, including rgrb, which is predicted to be involved in phototransduction. We found this gene has disrupted exons in all non-hybrid cave populations but intact reading frames in surface fish. Overall, our results suggest specific regions of the genome may play significant roles in driving adaptation to the cave environment in A. mexicanus and demonstrate how this compiled dataset can facilitate our understanding of the genetic basis of repeated evolution in the Mexican cavefish.
Perspectives of pediatric oncologists on referral for CAR-T therapy: a mixed methods pilot study
Authors: Hall Anurekha G , Duenas Devan M , Voutsinas Jenna , Wu Qian , Lamble Adam J , Gruber Elizabeth , Wilfond Benjamin , Park Julie R , Agrawal Anurag K , Marron Jonathan M 
Published: July 2024

Abstract

Background
Receipt of chimeric antigen receptor T-cell (CAR-T) therapy at an institution different from the primary oncologist’s institution is a complex, multistep process. Referral by oncologists plays an important role in the process but may be susceptible to bias.

Methods
Oncologists who previously referred patients for CAR-T therapy at 5 pediatric hospitals were sent surveys by email exploring their CAR-T referral practices. Descriptive statistics were generated, and multivariate analyses examined associations among oncologist characteristics, familiarity with CAR-T therapy, and referral practices. We conducted semistructured interviews with a subset of participants and used thematic analysis to code transcripts.

Results
Sixty-eight oncologists completed the survey; 77% expressed being “very familiar” with CAR-T therapy. Hispanic oncologists and oncologists at institutions with 50 or fewer new diagnoses per year were more likely to identify as less familiar with CAR-T therapy (odds ratio [OR] = 64.3, 95% confidence interval [CI] = 2.45 to 10 452.50, P = .04 and OR = 24.5, 95% CI = 3.3 to 317.3, P = .005, respectively). In total, 38% of respondents considered nonclinical features (compliance, social support, resources, insurance, language, education, and race or ethnicity) influential in referral decisions. Oncologists who were Hispanic and oncologists who had been practicing for 20 or more years were more likely to consider these features significantly influential (OR = 14.52, 95% CI = 1.49 to 358.66, P = .04 and OR = 6.76, 95% CI = 1.18 to 50.5, P = .04). Nine oncologists completed in-depth interviews; common themes included barriers and concerns regarding CAR-T therapy referral, the value of an established relationship with a CAR-T therapy center, and poor communication after CAR-T therapy.

Conclusions
Nearly 40% of oncologists consider nonclinical features significantly influential when deciding to refer patients for CAR-T therapy, raising concern for bias in the referral process. Establishing formal partnerships with CAR-T therapy centers may help address physician barriers in referral.
Clonal plasticity and trait stability facilitate knotweed invasion in Europe
Authors: Cao Pei-Pei , Yin Wan-Dong , Bi Jing-Wen , Lin Tian-Tian , Wang Sheng-Yu , Zhou Hang , Liao Zhi-Yong , Zhang Lei , Parepa Madalin , Ju Rui-Ting , Ding Jian-Qing , Nie Ming , Bossdorf Oliver , Richards Christina L , Wu Ji-Hua , Li Bo 
Published: July 2024

Abstract
Invasive plant species pose significant ecological and economic threats due to their establishment and dominance in non-native ranges. Previous studies have yielded mixed results regarding the plants’ adaptive mechanisms for thriving in new environments, and particularly, little is known about how the phenotypic plasticity of growth and defense-related traits may facilitate plant invasion. This study addressed these uncertainties by employing the aggressive weed Reynoutria japonica as a study model. We examined the differences in growth, defense-related traits and biomass allocation between R. japonica populations from native and introduced ranges grown in two common gardens with distinct climate conditions. Our results demonstrated that while the introduced populations did not exhibit increases in height and total dry mass, nor reductions in leaf defense levels, their investment in leaf production was significantly higher compared to the native populations. Additionally, introduced populations displayed greater phenotypic plasticity in clonal ramet but less phenotypic plasticity in biomass production than native populations across varying environments. These findings highlight the roles of phenotypic plasticity and specific trait adaptations, such as clonality, in the successful invasion of R. japonica. This study has important implications for managing invasive plant species under changing environmental conditions.
Cross-effects of cultural and gay capitals in access to refugee status on the grounds of SOGI in France: Study of the formal and informal preparations of West African men for asylum trials
Authors: Bouchet-Mayer Cyriac , Ferez Sylvain 
Published: July 2024

Abstract
According to literature, ethnocentric representations of homosexuality structure the decision to grant asylum, or not, on the ground of sexual orientation. This ethnocentric criticism has recently led to a technicalization of evaluation practices by asylum judges, which are now based on a narrative and discursive mastery, a field in which respondents are unequal depending on their cultural and gay capitals. While the assessment as such appears to be more equitable, Western norms of gender and sexuality, and practicing self-narrative through their prism, continue to impose themselves in different ways, particularly in formal associative accompaniment or in informal preparation for the refugee status determination process. A 2-fold ethnographic approach, attentive to associative backing and the daily experience of exile as formal and informal spaces of asylum preparation and identity formation, is used to analyse the manner in which cultural and gay capitals influence identity formation, preparation for asylum trials, and chances of obtaining refugee status.
Prothrombin deficiency with recurrent subretinal hemorrhage
Authors: Qama Eros , Krishnamurthy Kritika , Mulvey Joseph J , Liu Kenneth G , Fernandes David L , Fang Yanan 
Published: July 2024

Abstract
Ocular hemorrhage has been recorded in congenital factor deficiencies like hemophilia A, but it has never been documented in prothrombin deficiency. Here, we describe an unusual case of sudden vision loss in the right eye caused by subretinal hemorrhage following a coughing episode in a 67-year-old woman. Notably, the patient underwent left eye enucleation 12 years previously under similar circumstances due to subretinal hemorrhage. During the interview, it was discovered that the patient had a history of prothrombin deficiency, which was subsequently confirmed through laboratory testing. Aside from recurrent ocular bleeding and 1 instance of bleeding following dental extraction in childhood, there is no other history of bleeding. Subsequent molecular studies revealed a homozygous missense mutation at G1499A (Arg500Gln), a variant previously identified as R457Q. Although the likelihood of prothrombin deficiency initiating subretinal hemorrhage is low, it is likely to worsen retinal hemorrhage and contribute to difficulty in controlling bleeding. A comprehensive coagulation workup is essential in patients with ocular hemorrhage. Determining factor II activity should be included in individuals exhibiting variably prolonged prothrombin time and activated partial thromboplastin time with correction in mixing studies. Additional investigations, such as genetic sequencing and family studies, are advised for those with isolated low prothrombin levels.
Spices and Herbs Increase Vegetable Palatability Among Military Service Members
Authors: D’Adamo Christopher R , Troncoso Melissa R , Piedrahita Gabriela , Messing Joshua , Scott Jonathan M 
Published: July 2024

ABSTRACT

Introduction
Unhealthy eating behaviors are adversely impacting the health and performance of the U.S. armed forces. Vegetable intake, in particular, has been shown to be far below recommended levels in active duty military populations. Previous research in other populations has shown that the addition of spices and herbs can help overcome numerous barriers to vegetable intake. The goal of this study was to determine modifiable barriers to vegetable intake among a sample of active duty military service members at Naval Support Activity Bethesda and evaluate whether the addition of spices and herbs can help surmount these barriers.

Materials and Methods
Monadic sensory testing was conducted that compared typical preparation (butter and salt) of 4 vegetables (broccoli, carrots, cauliflower, and kale) vs. otherwise identical preparation with the addition of spices and herbs. The Menu Item Survey, a 9-point hedonic scale utilized throughout the U.S. Military for recipe development, was the primary outcome of the vegetable sensory testing. Questionnaires were administered to assess barriers to military dining facility vegetable intake. Unpaired t-tests were utilized to compare Menu Item Survey ratings of typical vegetables vs. vegetables with spices and herbs. Descriptive statistics were computed to summarize the results of the barriers questionnaires, and qualitative analysis of open-ended questions was conducted to identify perceived areas of improved vegetable intake.

Results
A diverse sample of 70 active duty service members participated in the vegetable sensory testing and provided outcome data. The most common barriers to military dining facility vegetable intake were appearance (42.9%), preparation style (41.3%), and taste (39.7%). Sensory testing revealed that vegetables with spices and herbs were preferred over typical preparations in overall appeal, flavor, and aroma (P &lt;.03).

Discussion
The addition of spices and herbs appears to help overcome key sensory-related barriers to military dining facility vegetable intake. Future comparison of vegetable intake with and without spices and herbs when included in a full meal in a military dining setting is warranted in order to better evaluate the effectiveness in increasing vegetable intake under typical dining conditions.
A normal broad line AGN SDSS J1617+0638 as the host galaxy of a central tidal disruption event
Authors: Zhang Xue-Guang 
Published: July 2024

ABSTRACT
In this manuscript, strong clues are reported to support the normal broad line AGN SDSS J1617+0638 as the host galaxy harbouring a central tidal disruption event (TDE). Through the optical flare in the CSS 8.5yr-long light curve and the none-variability in the up-to-date ASAS-SN light curves, the theoretical TDE model described by the mosfit code can be applied in SDSS J1617+0638. Meanwhile, considering the assumed central TDE expected continuum emissions not strong enough to describe the continuum emissions in the SDSS spectrum of SDSS J1617+0638, an additional power-law component from pre-existing AGN activity should be necessary in SDSS J1617+0638. Furthermore, considering the short time duration to the observed date for the SDSS spectrum from the starting time of the assumed central TDE in SDSS J1617+0638, TDE model expected accreting mass only about 0.03 $\mathrm{ M}_\odot$ can lead to few effects of TDEs debris on the observed broad emission lines in the SDSS spectrum of SDSS J1617+0638, indicating the TDE model determined BH mass simply consistent with the virial BH mass by broad emission lines, as determined results in SDSS J1617+0638. Therefore, through both the photometric variability and the spectroscopic results, a central TDE can be preferred in the normal broad line AGN SDSS J1617+0638 with pre-existing central AGN activity and pre-existing broad emission line regions.
Fast and Accurate Estimation of Selection Coefficients and Allele Histories from Ancient and Modern DNA
Authors: Vaughn Andrew H , Nielsen Rasmus 
Published: July 2024

Abstract
We here present CLUES2, a full-likelihood method to infer natural selection from sequence data that is an extension of the method CLUES. We make several substantial improvements to the CLUES method that greatly increases both its applicability and its speed. We add the ability to use ancestral recombination graphs on ancient data as emissions to the underlying hidden Markov model, which enables CLUES2 to use both temporal and linkage information to make estimates of selection coefficients. We also fully implement the ability to estimate distinct selection coefficients in different epochs, which allows for the analysis of changes in selective pressures through time, as well as selection with dominance. In addition, we greatly increase the computational efficiency of CLUES2 over CLUES using several approximations to the forward–backward algorithms and develop a new way to reconstruct historic allele frequencies by integrating over the uncertainty in the estimation of the selection coefficients. We illustrate the accuracy of CLUES2 through extensive simulations and validate the importance sampling framework for integrating over the uncertainty in the inference of gene trees. We also show that CLUES2 is well-calibrated by showing that under the null hypothesis, the distribution of log-likelihood ratios follows a χ2 distribution with the appropriate degrees of freedom. We run CLUES2 on a set of recently published ancient human data from Western Eurasia and test for evidence of changing selection coefficients through time. We find significant evidence of changing selective pressures in several genes correlated with the introduction of agriculture to Europe and the ensuing dietary and demographic shifts of that time. In particular, our analysis supports previous hypotheses of strong selection on lactase persistence during periods of ancient famines and attenuated selection in more modern periods.
Endosomal catabolism of phosphatidylinositol 4,5-bisphosphate is fundamental in building resilience against pathogens
Authors: Yang Chao , Yao Longfeng , Chen Dan , Chen Changling , Li Wenbo , Tong Hua , Cheng Zihang , Yan Yanling , Lin Long , Zhang Jing , Shi Anbing 
Published: July 2024

Abstract
Endosomes are characterized by the presence of various phosphoinositides that are essential for defining the membrane properties. However, the interplay between endosomal phosphoinositides metabolism and innate immunity is yet to be fully understood. Here, our findings highlight the evolutionary continuity of RAB-10/Rab10’s involvement in regulating innate immunity. Upon infection of Caenorhabditis elegans with Pseudomonas aeruginosa, an increase in RAB-10 activity was observed in the intestine. Conversely, when RAB-10 was absent, the intestinal diacylglycerols (DAGs) decreased, and the animal’s response to the pathogen was impaired. Further research revealed that UNC-16/JIP3 acts as an RAB-10 effector, facilitating the recruitment of phospholipase EGL-8 to endosomes. This leads to a decrease in endosomal phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) and an elevation of DAGs, as well as the activation of the PMK-1/p38 MAPK innate immune pathway. It is noteworthy that the dimerization of UNC-16 is a prerequisite for its interaction with RAB-10(GTP) and the recruitment of EGL-8. Moreover, we ascertained that the rise in RAB-10 activity, due to infection, was attributed to the augmented expression of LET-413/Erbin, and the nuclear receptor NHR-25/NR5A1/2 was determined to be indispensable for this increase. Hence, this study illuminates the significance of endosomal PI(4,5)P2 catabolism in boosting innate immunity and outlines an NHR-25-mediated mechanism for pathogen detection in intestinal epithelia.
The Importance of Emotional Intelligence in Social Work Students and Its Relation to Perceived Efficacy
Authors: Chinchilla Francisco Lucas , Fernández Natalia Beni , Queiruga Dolores Alicia , Montañés Muro Pilar 
Published: July 2024

Abstract
Social workers have a greater than average risk of suffering burnout syndrome. In the same way as the professionals, students too can suffer academic burnout. However, few empirical studies have studied burnout and protective factors in social work students exclusively. Emotional intelligence (EI) has been described as a protective factor for burnout both in the professional and the academic context. The present study aims to explore which components of EI predict the burnout domains in students studying a degree in social work, in Spain. To this end, 87 social work students completed a questionnaire in which information was gathered on EI, burnout, average grade in the degree, and sociodemographic variables. The regression analysis results indicate that the students with poorer academic success and from higher years reported greater symptoms of burnout. Regarding the components of EI, emotional clarity and emotional repair predict the academic efficacy perceived by the students. These results highlight the importance of including EI in academic policies to promote the design of EI training programs aimed at developing EI skills, particularly emotional clarity and emotional repair, as a way of improving the perception of efficacy in social work students.