bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparative Effectiveness of Unruptured Cerebral Aneurysm Therapies
Authors: McDonald Jennifer S. , McDonald Robert J. , Fan Jiaquan , Kallmes David F. , Lanzino Giuseppe , Cloft Harry J. 
Published: March 2013

Background and Purpose—
Endovascular therapy has increasingly become the most common treatment for unruptured cerebral aneurysms in the United States. We evaluated a national, multi-hospital database to examine recent utilization trends and compare periprocedural outcomes between clipping and coiling treatments of unruptured aneurysms.

Methods—
The Premier Perspective database was used to identify patients hospitalized between 2006 to 2011 for unruptured cerebral aneurysm who underwent clipping or coiling therapy. A logistic propensity score was generated for each patient using relevant patient, procedure, and hospital variables, representing the probability of receiving clipping. Covariate balance was assessed using conditional logistic regression. Following propensity score adjustment using 1:1 matching methods, the risk of in-hospital mortality and morbidity was compared between clipping and coiling cohorts.

Results—

A total of 4899 unruptured aneurysm patients (1388 clipping, 3551 coiling) treated at 120 hospitals were identified. Following propensity score adjustment, clipping patients had a similar likelihood of in-hospital mortality (odds ratio [OR], 1.43; 95% confidence interval [CI], 0.49–4.44;
P
=0.47) but a significantly higher likelihood of unfavorable outcomes, including discharge to long-term care (OR, 4.78; 95% CI, 3.51–6.58;
P
<0.0001), ischemic complications (OR, 3.42; 95% CI, 2.39–4.99;
P
<0.0001), hemorrhagic complications (OR, 2.16; 95% CI, 1.33–3.57;
P
<0.0001), postoperative neurological complications (OR, 3.39; 95% CI, 2.25–5.22;
P
<0.0001), and ventriculostomy (OR, 2.10; 95% CI, 1.01–4.61;
P
=0.0320) compared with coiling patients.

Conclusions—
Among patients treated for unruptured intracranial aneurysms in a large sample of hospitals in the United States, clipping was associated with similar mortality risk but significantly higher periprocedural morbidity risk compared with coiling.
Development of a Point-based Prediction Model for the Incidence of Total Stroke
Authors: Yatsuya Hiroshi , Iso Hiroyasu , Yamagishi Kazumasa , Kokubo Yoshihiro , Saito Isao , Suzuki Kazuo , Sawada Norie , Inoue Manami , Tsugane Shoichiro 
Published: March 2013

Background and Purpose—
An individualized risk score for the development of stroke may be a useful tool to motivate patients to modify their risk behaviors. We developed and validated a point-based prediction model (risk score) for stroke incidence using a Japanese cohort of general men and women.

Methods—

The Japan Public Health Center-based prospective study cohort II (age range, 40–69 years at baseline in 1993–1994; n=15 672) was used to derive the point-based model according to Cox regression results. The model was externally validated using the Japan Public Health Center study cohort I and also by bootstrap methods within cohort II. The model discrimination was evaluated by the area under the receiver operating characteristic curve, model calibration, by the Grønnesby–Borgan χ
2
statistic. Vascular age was also calculated.

Results—
During 14 years of follow-up, 790 incident stroke cases occurred. Variables selected for the model were age, sex, current smoking, body mass index, blood pressure, antihypertensive medication use, and diabetes mellitus. Interactions of sex with current smoking and of antihypertensive medication use with systolic blood pressure were statistically significant. The point-based model discriminated reasonably well (area under the receiver operating characteristic curve, 0.73). The area under the receiver operating characteristic curve of the point-based model applied externally to cohort I was reasonably good: 0.69. A 50-year-old man with diabetes mellitus and hypertension has an estimated vascular age of 69 years. High normal blood pressure and grade 1 hypertension accounted for one third of the stroke incidence.

Conclusions—
We developed score to predict 10-year stroke risk using variables that are easily available in the community setting.
Beobachtungen zur Turfan-Chandoviciti
Authors: Chen Ruixuan 
Published: March 2013

In 1958, a number of birchbark fragments in the Berlin collection of Turfan manuscripts were edited and published by Dieter Schlingloff under the title of Chandoviciti. He ascribed them to three independent texts on Sanskrit metrics, which contained numerous exemplary verses of a wide variety of Sanskrit meters. Therefore some scholars felt justified in assuming that the texts dated by Schlingloff in the second half of the fourth century ce were originally a collection of exemplary verses. Nevertheless the textual history of those texts remains obscure. This recent research is based on a scrutiny of the original source, while bringing about a correction of several readings. Furthermore, some palaeographical remarks might be able to suggest a somewhat later dating of the manuscripts in question than that proposed by Schlingloff. With regard to the title of this treatise, it follows from a historical perspective that Chandoviciti per se as a title would hardly be probable, if not impossible. In the last part of this article, light is shed on the internal diversity and inconsistency among those exemplary verses, which render it plausible that the so-called Turfan-Chandoviciti could have been a „mixed“ booklet compiled from at least four different sources which was then continuously abridged over the course of time from the very beginning of its spread along the Silk Road up to its final entry into Xinjiang.
Children's Perception of Aged Persons and Grandparents
Authors: Marcoen Alfons 
Published: March 2013

Because results with regard to children's perception of the elderly contradict each other, it is necessary to differentiate between several groups of subjects, different groups of aged stimulus persons and various dimensions of the image or concept formed. In this study an investigation is made of the characteristics and quality of the image children have of aged persons in general and of their grandparents. A sample of 114 second-, fourth-and sixth-graders, boys and girls, drew successively an aged man and woman and their grandfather and grandmother. Those figures are examined and compared with regard to the richness of the drawings (the number of characteristics drawn) and number of deficit and old age life style characteristics. An analysis of variance is made in order to examine the influence and interaction of two between-subject variables - sex (S) and age of child (A) -and two within-subject variables - sex (Ssp) and kinship of stimulus person (K). Relating to the richness of the drawings, S, A, and K show a principal effect, in relating to the proportion of deficit characteristics there is a principal influence of S, A, K and Ssp. Ssp and K show a principal effect relating to the old age life style characteristics. Some specific characteristics are more often used for one or two figures, or more often used by boys or girls, second-, fourth-or sixth-graders.
Use of Pulsed Dye Laser in the Treatment of Sulcus Vocalis
Authors: Hwang Chi Sang , Lee Hyun Jin , Ha Jong Gyun , Cho Chang Il , Kim Na Hyun , Hong Hyun Jun , Choi Hong‐Shik 
Published: March 2013

ObjectiveThe pulsed dye laser (PDL) has been shown to be effective in the treatment of hypertrophic scars and keloids in dermatology. On the basis of histopathologic similarities between sulcus vocalis and scar tissue and numerous reports on the treatment of laryngeal lesions, especially scar tissue, with PDL, we evaluated the efficacy of treating sulcus vocalis with PDL. We named this surgical procedure PDL glottoplasty.Study DesignCase series with planned data collection.SettingA university‐based, tertiary care medical center.Subjects and MethodsThis study was conducted on 25 patients diagnosed with sulcus vocalis by videostroboscopy at the Gangnam Severance Hospital Otorhinolaryngology Department between August 2006 and February 2012. Energy delivery was fixed at 0.75 Joules (J) per pulse, and each vocal fold was administered 60 to 110 pulses (average 72.5 pulses) during each procedure. Aerodynamic, stroboscopic, and acoustic voice analyses were performed pre‐ and postoperatively.ResultsAlthough assessment was necessarily subjective, our study indicated that vocal folds showed decreased stiffness and improved mucosal wave properties after treatment, resulting in improved vibration and dysphonia. In the objective assessments, most patients who underwent PDL glottoplasty showed improvement in several postoperative voice analysis indices. The differences between preoperative and some postoperative voice parameter indices were statistically significant.ConclusionWe found PDL glottoplasty to be beneficial in the treatment of sulcus vocalis. Objective measurements of voice quality and normalization of vocal fold vibration improved after PDL treatment in most cases. Our results warrant further studies with larger numbers of participants and longer follow‐up periods.
Higher bone marrow LGALS3 expression is an independent unfavorable prognostic factor for overall survival in patients with acute myeloid leukemia
Authors: Cheng Chieh-Lung , Hou Hsin-An , Lee Ming-Cheng , Liu Chieh-Yu , Jhuang Jie-Yang , Lai Yan-Jun , Lin Chung-Wu , Chen Huan-Yuan , Liu Fu-Tong , Chou Wen-Chien , Chen Chien-Yuan , Tang Jih-Luh , Yao Ming , Huang Shang-Yi , Ko Bor-Sheng , Wu Shang-Ju , Tsay Woei , Tien Hwei-Fang 
Published: March 2013

Key PointsBone marrow LGALS3 expression is associated with distinct clinical and biological features in patients with acute myeloid leukemia. Higher bone marrow LGALS3 expression is an independent poor prognostic factor for overall survival and may serve as a potential therapeutic target.
PacC and pH–dependent transcriptome of the mycotrophic fungus Trichoderma virens
Authors: Trushina Naomi , Levin Michal , Mukherjee Prasun K , Horwitz Benjamin A 
Published: March 2013

Abstract

Background
In fungi, environmental pH is an important signal for development, and successful host colonization depends on homeostasis. Surprisingly, little is known regarding the role of pH in fungal-fungal interactions. Species of Trichoderma grow as soil saprobes but many are primarily mycotrophic, using other fungi as hosts. Therefore, Trichoderma spp. are studied for their potential in biocontrol of plant diseases. Particularly in alkaline soil, pH is a critical limiting factor for these biofungicides, whose optimal growth pH is 4–6. Gaining an understanding of pH adaptability is an important step in broadening the activity spectrum of these economically important fungi.

Results
We studied the pH-responsive transcription factor PacC by gene knockout and by introduction of a constitutively active allele (pacC

c
). ΔpacC mutants exhibited reduced growth at alkaline pH, while pacC

c
strains grew poorly at acidic pH. In plate confrontation assays ΔpacC mutants showed decreased ability to compete with the plant pathogens Rhizoctonia solani and Sclerotium rolfsii. The pacC

c
strain exhibited an overgrowth of R. solani that was comparable to the wild type, but was unable to overgrow S. rolfsii. To identify genes whose expression is dependent on pH and pacC, we designed oligonucleotide microarrays from the transcript models of the T. virens genome, and compared the transcriptomes of wild type and mutant cultures exposed to high or low pH. Transcript levels from several functional classes were dependent on pacC, on pH, or on both. Furthermore, the expression of a set of pacC-dependent genes was increased in the constitutively-active pacC

c
strain, and was pH-independent in some, but not all cases.

Conclusions
PacC is important for biocontrol-related antagonism of other fungi by T. virens. As much as 5% of the transcriptome is pH-dependent, and of these genes, some 25% depend on pacC. Secondary metabolite biosynthesis and ion transport are among the relevant gene classes. We suggest that ΔpacC mutants may have lost their full biocontrol potential due to their inability to adapt to alkaline pH, to perceive ambient pH, or both. The results raise the novel possibility of genetically manipulating Trichoderma in order to improve adaptability and biocontrol at alkaline pH.
Chondroblastoma associated with aneurysmal cyst of the navicular bone: a case report
Authors: Fang Zhenhua , Chen Ming 
Published: March 2013

Abstract
Chondroblastoma is a rare tumor. It is usually benign; however, it can have an aggressive course before or after operative treatment, even resulting in pulmonary metastases. The foot is a rare location for chondroblastoma, and to our knowledge, chondroblastoma occurring in the navicular bone has not been reported previously in the English literature. We describe a case of navicular chondroblastoma case associated with an aneurysmal bone cyst. Treatment consisted of aggressive curettage, phenolization, and bone allograft. The patient was able to resume normal activities after treatment, and there was no recurrence of the chondroblastoma during a follow-up of 3 years.
Cathepsin B: a potential prognostic marker for inflammatory breast cancer
Authors: Nouh Mohamed A , Mohamed Mona M , El-Shinawi Mohamed , Shaalan Mohamed A , Cavallo-Medved Dora , Khaled Hussein M , Sloane Bonnie F 
Published: March 2013

Abstract

Background
Inflammatory breast cancer (IBC) is the most aggressive form of breast cancer. In non-IBC, the cysteine protease cathepsin B (CTSB) is known to be involved in cancer progression and invasion; however, very little is known about its role in IBC.

Methods
In this study, we enrolled 23 IBC and 27 non-IBC patients. All patient tissues used for analysis were from untreated patients. Using immunohistochemistry and immunoblotting, we assessed the levels of expression of CTSB in IBC versus non-IBC patient tissues. Previously, we found that CTSB is localized to caveolar membrane microdomains in cancer cell lines including IBC, and therefore, we also examined the expression of caveolin-1 (cav-1), a structural protein of caveolae in IBC versus non-IBC tissues. In addition, we tested the correlation between the expression of CTSB and cav-1 and the number of positive metastatic lymph nodes in both patient groups.

Results
Our results revealed that CTSB and cav-1 were overexpressed in IBC as compared to non-IBC tissues. Moreover, there was a significant positive correlation between the expression of CTSB and the number of positive metastatic lymph nodes in IBC.

Conclusions
CTSB may initiate proteolytic pathways crucial for IBC invasion. Thus, our data demonstrate that CTSB may be a potential prognostic marker for lymph node metastasis in IBC.
Transmigration of polymorphnuclear neutrophils and monocytes through the human blood-cerebrospinal fluid barrier after bacterial infection in vitro
Authors: Steinmann Ulrike , Borkowski Julia , Wolburg Hartwig , Schröppel Birgit , Findeisen Peter , Weiss Christel , Ishikawa Hiroshi , Schwerk Christian , Schroten Horst , Tenenbaum Tobias 
Published: March 2013

AbstractBackgroundBacterial invasion through the blood-cerebrospinal fluid barrier (BCSFB) during bacterial meningitis causes secretion of proinflammatory cytokines/chemokines followed by the recruitment of leukocytes into the CNS. In this study, we analyzed the cellular and molecular mechanisms of polymorphonuclear neutrophil (PMN) and monocyte transepithelial transmigration (TM) across the BCSFB after bacterial infection.MethodsUsing an inverted transwell filter system of human choroid plexus papilloma cells (HIBCPP), we studied leukocyte TM rates, the migration route by immunofluorescence, transmission electron microscopy and focused ion beam/scanning electron microscopy, the secretion of cytokines/chemokines by cytokine bead array and posttranslational modification of the signal regulatory protein (SIRP) α via western blot.ResultsPMNs showed a significantly increased TM across HIBCPP after infection with wild-typeNeisseria meningitidis(MC58). In contrast, a significantly decreased monocyte transmigration rate after bacterial infection of HIBCPP could be observed. Interestingly, in co-culture experiments with PMNs and monocytes, TM of monocytes was significantly enhanced. Analysis of paracellular permeability and transepithelial electrical resistance confirmed an intact barrier function during leukocyte TM. With the help of the different imaging techniques we could provide evidence for para- as well as for transcellular migrating leukocytes. Further analysis of secreted cytokines/chemokines showed a distinct pattern after stimulation and transmigration of PMNs and monocytes. Moreover, the transmembrane glycoprotein SIRPα was deglycosylated in monocytes, but not in PMNs, after bacterial infection.ConclusionsOur findings demonstrate that PMNs and monoctyes differentially migrate in a human BCSFB model after bacterial infection. Cytokines and chemokines as well as transmembrane proteins such as SIRPα may be involved in this process.
Mesenchymal stem cell derived hematopoietic cells are permissive to HIV-1 infection
Authors: Nazari-Shafti Timo Z , Freisinger Eva , Roy Upal , Bulot Christine T , Senst Christiane , Dupin Charles L , Chaffin Abigail E , Srivastava Sudesh K , Mondal Debasis , Alt Eckhard U , Izadpanah Reza 
Published: March 2013

AbstractBackgroundTissue resident mesenchymal stem cells (MSCs) are multipotent, self-renewing cells known for their differentiation potential into cells of mesenchymal lineage. The ability of single cell clones isolated from adipose tissue resident MSCs (ASCs) to differentiate into cells of hematopoietic lineage has been previously demonstrated. In the present study, we investigated if the hematopoietic differentiated (HD) cells derived from ASCs could productively be infected with HIV-1.ResultsHD cells were generated by differentiating clonally expanded cultures of adherent subsets of ASCs (CD90+, CD105+, CD45-, and CD34-). Transcriptome analysis revealed that HD cells acquire a number of elements that increase their susceptibility for HIV-1 infection, including HIV-1 receptor/co-receptor and other key cellular cofactors. HIV-1 infected HD cells (HD-HIV) showed elevated p24 protein andgagandtatgene expression, implying a high and productive infection. HD-HIV cells showed decreasedCD4, but significant increase in the expression ofCCR5,CXCR4,Nef-associated factorHCK, andVpu-associated factorBTRC. HIV-1 restricting factors like APOBEC3F and TRIM5 also showed up regulation. HIV-1 infection increased apoptosis and cell cycle regulatory genes in HD cells. Although undifferentiated ASCs failed to show productive infection, HIV-1 exposure increased the expression of several hematopoietic lineage associated genes such asc-Kit,MMD2, andIL-10.ConclusionsConsidering the presence of profuse amounts of ASCs in different tissues, these findings suggest the possible role that could be played by HD cells derived from ASCs in HIV-1 infection. The undifferentiated ASCs were non-permissive to HIV-1 infection; however, HIV-1 exposure increased the expression of some hematopoietic lineage related genes. The findings relate the importance of ASCs in HIV-1 research and facilitate the understanding of the disease process and management strategies.
EMT is the dominant program in human colon cancer
Authors: Loboda Andre , Nebozhyn Michael V , Watters James W , Buser Carolyne A , Shaw Peter Martin , Huang Pearl S , Van't Veer Laura , Tollenaar Rob AEM , Jackson David B , Agrawal Deepak , Dai Hongyue , Yeatman Timothy J 
Published: March 2013

Abstract

Background
Colon cancer has been classically described by clinicopathologic features that permit the prediction of outcome only after surgical resection and staging.

Methods
We performed an unsupervised analysis of microarray data from 326 colon cancers to identify the first principal component (PC1) of the most variable set of genes. PC1 deciphered two primary, intrinsic molecular subtypes of colon cancer that predicted disease progression and recurrence.

Results
Here we report that the most dominant pattern of intrinsic gene expression in colon cancer (PC1) was tightly correlated (Pearson R = 0.92, P < 10-135) with the EMT signature-- both in gene identity and directionality. In a global micro-RNA screen, we further identified the most anti-correlated microRNA with PC1 as MiR200, known to regulate EMT.

Conclusions
These data demonstrate that the biology underpinning the native, molecular classification of human colon cancer--previously thought to be highly heterogeneous-- was clarified through the lens of comprehensive transcriptome analysis.
Driving and dementia: a clinician's guide
Authors: Wilson Sarah , Pinner Gill 
Published: March 2013

SummaryWith an ageing population and more drivers on the road, the number of drivers with dementia is due to grow exponentially over the next 50 years. Although decisions regarding possession of a driving licence in the UK are made by the Driver and Vehicle Licensing Agency (DVLA), psychiatrists have a duty to advise patients who are unfit to drive to cease driving and to inform the DVLA of patients who pose a risk to the public by continuing to drive when advised not to. This article offers a review of the literature on dementia and driving and summarises the evidence and advice for navigating this minefield. The use of psychological test batteries in clinical practice is discussed, along with the most useful questions to ask in memory clinics. Legal guidance for various countries is considered, as is the important (but often overlooked) issue of helping older people prepare for retirement from driving.
Affective disorders and risk of developing dementia: systematic review
Authors: da Silva Joaquim , Gonçalves-Pereira Manuel , Xavier Miguel , Mukaetova-Ladinska Elizabeta B. 
Published: March 2013

BackgroundAffective disorders are associated with cognitive disturbances but their role as risk factors for dementia is still not fully investigated.AimsTo evaluate the risk of developing dementia in individuals with a history of affective disorder.MethodWe conducted a systematic review of case-control and cohort studies addressing the risk of developing dementia in people with affective disorders. To the best of our knowledge, this is the first systematic review that has included studies evaluating this risk specifically in people with bipolar disorder.ResultsFifty-one studies were included. Most of the studies found an increased risk for developing dementia in individuals with depression. Greater frequency and severity of depressive episodes seem to increase this risk. The evidence is contradictory regarding whether there is a difference in risk in people with early- or late-onset depression. The few available risk estimates for dementia in people with bipolar disorder suggest an even higher risk than for those with depression.ConclusionsAffective disorders appear to be associated with an increased risk of developing dementia, and one that is dependent on clinical and demographic variables. Depression may be both a prodrome and a risk factor for dementia. Future research should aim to elucidate the mechanisms that mediate these links.