bluuebunny/crossref_metadata_2025_split huggingface dataset:
Distribution and diagnostic value of single and multiple high‐risk HPV infections in detection of cervical intraepithelial neoplasia: A retrospective multicenter study in China
Authors: Ye Zichen , Zhao Yuankai , Chen Mingyang , Lu Qu , Wang Jiahui , Cui Xiaoli , Wang Huike , Xue Peng , Jiang Yu 
Published: August 2024

AbstractThe risk associated with single and multiple human papillomavirus (HPV) infections in cervical intraepithelial neoplasia (CIN) remains uncertain. This study aims to explore the distribution and diagnostic significance of the number of high‐risk HPV (hr‐HPV) infections in detecting CIN, addressing a crucial gap in our understanding. This comprehensive multicenter, retrospective study meticulously analyzed the distribution of single and multiple hr‐HPV, the risk of CIN2+, the relationship with CIN, and the impact on the diagnostic performance of colposcopy using demographic information, clinical histories, and tissue samples. The composition of a single infection was predominantly HPV16, 52, 58, 18, and 51, while HPV16 and 33 were identified as the primary causes of CIN2+. The primary instances of dual infection were mainly observed in combinations such as HPV16/18, HPV16/52, and HPV16/58, while HPV16/33 was identified as the primary cause of CIN2+. The incidence of hr‐HPV infections shows a dose–response relationship with the risk of CIN (p for trend <0.001). Compared to single hr‐HPV, multiple hr‐HPV infections were associated with increased risks of CIN1 (1.44, 95% confidence interval [CI]: 1.20–1.72), CIN2 (1.70, 95% CI: 1.38–2.09), and CIN3 (1.08, 95% CI: 0.86–1.37). The colposcopy‐based specificity of single hr‐HPV (93.4, 95% CI: 92.4–94.4) and multiple hr‐HPV (92.9, 95% CI: 90.8–94.6) was significantly lower than negative (97.9, 95% CI: 97.0–98.5) in detecting high‐grade squamous intraepithelial lesion or worse (HSIL+). However, the sensitivity of single hr‐HPV (73.5, 95% CI: 70.8–76.0) and multiple hr‐HPV (71.8, 95% CI: 67.0–76.2) was higher than negative (62.0, 95% CI: 51.0–71.9) in detecting HSIL+. We found that multiple hr‐HPV infections increase the risk of developing CIN lesions compared to a single infection. Colposcopy for HSIL+ detection showed high sensitivity and low specificity for hr‐HPV infection. Apart from HPV16, this study also found that HPV33 is a major pathogenic genotype.
An improved natural stabilized nodal integration for locking‐related materials in meshfree methods
Authors: Nguyen Huy Anh , Tanaka Satoyuki , Bui Tinh Quoc 
Published: August 2024

AbstractAn improved naturally stabilized nodal integration (NSNI) is presented for resolving displacement locking concerned with highly orthotropic and nearly incompressible materials in the linear setting. It is recognized that the original NSNI is susceptible to the locking when dealing with these types of materials. The proposed method utilizes spectral decomposition to split the elasticity matrix into stiff and nonstiff parts. The terms associated with the stiff modes in the bilinear form are sampled by nodal integration (NI) without stabilization, whereas the other terms are integrated with NSNI. This approach leads to a unified implementation to handle locking in both types of materials. The performance and convergence of the proposed formulation are verified through several two‐ and three‐dimensional numerical examples, illustrating the advantages of the presented method over its standard counterpart.
NMRK2 is an efficient diagnostic indicator for Xp11.2 translocation renal cell carcinoma
Authors: Feng Huayi , Cao Shouqing , Fu Shihui , Liu Junxiao , Gao Yu , Dong Zhouhuan , Cai Tianwei , Wen Lequan , Xiong Zhuang , Li Shangwei , Zhang Xu , Ma Xin , Li Xiubin 
Published: August 2024

AbstractXp11.2 translocation renal cell carcinomas (tRCC) are a rare and highly malignant type of renal cancer, lacking efficient diagnostic indicators and therapeutic targets. Through the analysis of public databases and our cohort, we identified NMRK2 as a potential diagnostic marker for distinguishing Xp11.2 tRCC from kidney renal clear cell carcinoma (KIRC) and kidney renal papillary cell carcinoma (KIRP) due to its specific upregulation in Xp11.2 tRCC tissues. Mechanistically, we discovered that TFE3 fusion protein binds to the promoter of the NMRK2 gene, leading to its upregulation. Importantly, we established RNA‐ and protein‐based diagnostic methods for identifying Xp11.2 tRCC based on NMRK2 expression levels, and the diagnostic performance of our methods was comparable to a dual‐color break‐apart fluorescence in situ hybridization assay. Moreover, we successfully identified fresh Xp11.2 tRCC tissues after surgical excision using our diagnostic methods and established an immortalized Xp11.2 tRCC cell line for further research purposes. Functional studies revealed that NMRK2 promotes the progression of Xp11.2 tRCC by upregulating the NAD+/NADH ratio, and supplementation with β‐nicotinamide mononucleotide (NMN) or nicotinamide riboside chloride (NR), effectively rescued the phenotypes induced by the knockdown of NMRK2 in Xp11.2 tRCC. Taken together, these data introduce a new diagnostic indicator capable of accurately distinguishing Xp11.2 tRCC and highlight the possibility of developing novel targeted therapeutics. © 2024 The Pathological Society of Great Britain and Ireland.
The ERA5 global reanalysis from 1940 to 2022
Authors: Soci Cornel , Hersbach Hans , Simmons Adrian , Poli Paul , Bell Bill , Berrisford Paul , Horányi András , Muñoz‐Sabater Joaquín , Nicolas Julien , Radu Raluca , Schepers Dinand , Villaume Sebastien , Haimberger Leopold , Woollen Jack , Buontempo Carlo , Thépaut Jean‐Noël 
Published: August 2024

AbstractWe provide a description and concise evaluation of the European Centre of Medium‐range Weather Forecasts Reanalysis v.5 (ERA5) global reanalysis from an additional extension back to 1940 that was released in March 2023, including its timely updates to the end of 2022. The ERA5 product from 1979 to end 2020 and a preliminary back extension from 1950 to 1978 have already been described elsewhere. The new back extension that spans 1940 to 1978 represents the official release and supersedes the preliminary product. Currently, the ERA5 data record extends over more than 83 years of hourly global three‐dimensional fields for many quantities that describe the global atmosphere, land surface, and ocean waves at a horizontal resolution of about 31 km. ERA5 relies on the ingestion of sub‐daily in‐situ and satellite observations, and the number of these increases from 17,000 per day in 1940 to 25 million per day by 2022. Accordingly, the quality of the reanalysis improves throughout the period. Over the Northern Hemisphere ERA5 generally provides a reliable representation of the synoptic situation from the early 1940s and provides long‐term variability that is in line with other datasets. Over the Southern Hemisphere, however, for the early period the description of ERA5 seems mainly statistical. Furthermore, there is a small deviation in surface temperature compared with reconstructions based on monthly aggregations of observations over land before 1946. For this period, the absence of upper air temperature observations reveals a model cold bias in the lower stratosphere. For the period from 1950 to 1978, the final release described here improves on the suboptimal treatment of International Best Track Archive for Climate Stewardship observations in the preliminary release, with, as a result, a much more homogeneous representation of tropical cyclones over the entire ERA5 record. Longer spin‐up periods also have a beneficial impact on soil moisture.
Sumsets and entropy revisited
Authors: Green Ben , Manners Freddie , Tao Terence 
Published: August 2024

AbstractThe entropic doubling of a random variable taking values in an abelian group is a variant of the notion of the doubling constant of a finite subset of , but it enjoys somewhat better properties; for instance, it contracts upon applying a homomorphism. In this paper we develop further the theory of entropic doubling and give various applications, including: (1) A new proof of a result of Pálvölgyi and Zhelezov on the “skew dimension” of subsets of with small doubling; (2) A new proof, and an improvement, of a result of the second author on the dimension of subsets of with small doubling; (3) A proof that the Polynomial Freiman–Ruzsa conjecture over implies the (weak) Polynomial Freiman–Ruzsa conjecture over .
Constructing Multi‐Electron Reactions by Doping Mn2+ to Increase Capacity and Stability in K3.2V2.8Mn0.2(PO4)4/C of Phosphate Cathodes for Potassium‐Ion Batteries
Authors: Wang Shengmei , Xiong Shuangsheng , Li Zheng , Zhao Yueqi , Tao Xiwen , Gao Faming , Gao Yuan , Hou Li 
Published: August 2024

AbstractVanadium‐based phosphate cathode materials (e.g., K3V2(PO4)3) have attracted widespread concentration in cathode materials in potassium‐ion batteries owing to their stable structure but suffer from low capacity and poor conductivity. In this work, an element doping strategy is applied to promote its electrochemical performance so that K3.2V2.8Mn0.2(PO4)4/C is prepared via a simple sol‐gel method. The heterovalent Mn2+ is introduced to stimulated multiple electron reactions to improve conductivity and capacity, as well as interlayer spacing. Galvanostatic intermittent titration technique (GITT) and in situ X‐ray diffraction results further confirm that Mn‐doping in the original electrode can obtain superior electrode process kinetics and structural stability. The prepared K3.2V2.8Mn0.2(PO4)4/C exhibits a high‐capacity retention of 80.8% after 1 500 cycles at 2 C and an impressive rate capability, with discharge capacities of 87.6 at 0.2 C and 45.4 mA h g−1 at 5 C, which is superior to the majority of reported vanadium‐based phosphate cathode materials. When coupled K3.2V2.8Mn0.2(PO4)4/C cathode with commercial porous carbon (PC) anode as the full cell, a prominent energy density of 175 Wh kg−1 is achieved based on the total active mass. Overall, this study provides an effective strategy for meliorating the cycling stability and capacity of the polyanion cathodes for KIB.
Graphene Terahertz Devices for Sensing and Communication
Authors: Samaha Anna‐Christina , Doumani Jacques , Kritzell T. Elijah , Xu Hongjing , Baydin Andrey , Ajayan Pulickel M. , Tahchi Mario El , Kono Junichiro 
Published: August 2024

AbstractGraphene‐based terahertz (THz) devices have emerged as promising platforms for a variety of applications, leveraging graphene's unique optoelectronic properties. This review explores recent advancements in utilizing graphene in THz technology, focusing on two main aspects: THz molecular sensing and THz wave modulation. In molecular sensing, the environment‐sensitive THz transmission and emission properties of graphene are utilized for enabling molecular adsorption detection and biomolecular sensing. This capability holds significant potential, from the detection of pesticides to DNA at high sensitivity and selectivity. In THz wave modulation, crucial for next‐generation wireless communication systems, graphene demonstrates remarkable potential in absorption modulation when gated. Novel device structures, spectroscopic systems, and metasurface architectures have enabled enhanced absorption and wave modulation. Furthermore, techniques such as spatial phase modulation and polarization manipulation have been explored. From sensing to communication, graphene‐based THz devices present a wide array of opportunities for future research and development. Finally, advancements in sensing techniques not only enhance biomolecular analysis but also contribute to optimizing graphene's properties for communication by enabling efficient modulation of electromagnetic waves. Conversely, developments in communication strategies inform and enhance sensing capabilities, establishing a mutually beneficial relationship.
Myocardial inefficiency in asynchronous segmental early relaxation with exercise: A case series
Authors: Allwood Richard P. 
Published: August 2024

AbstractAsynchronous segmental early relaxation phenomenon (ASERP) is a condition infrequently reported in exercise stress echocardiography and is characterised by sudden localised outward motion of the left ventricle during the isovolumic relaxation period. ASERP has been seen on angiographic studies at rest, which examined the extent of wall motion from end‐diastolic and end‐systolic frames. However, this method does not allow for an assessment of the timing of wall motion. With technological advances in echocardiography, advanced tools such as two‐dimensional (2D) speckle‐tracking and myocardial work, may allow for the precise timing and extent of ASERP to be more accurately identified during systole and diastole and provide assessment of myocardial performance. Two cases of ASERP are reported occurring in those with a high hemodynamic response and exaggerated systolic blood pressure response with exercise. The diagnostic characteristics of ASERP will be explored, including the use of 2D speckle‐tracking and myocardial work.
The importance of early strength in structural applications: Obsidian‐based geopolymer mortars and silica fume substitution study
Authors: Cakmak Talip , Ustabas Ilker , Kurt Zafer , Gurbuz Ali 
Published: August 2024

AbstractGeopolymer mortars, which cause less CO2 emissions than concrete and its raw material cement, are an innovative, environmentally friendly and sustainable building material. Geopolymers are formed by activating silica and alumina materials with alkaline activators. In this study, a geopolymer mortar containing obsidian (OB), also known as volcanic glass, which is free, and silica fume (SF), which is the waste material of the silicon and ferrosilicon industry, was investigated. The behavior of OB‐based geopolymer mortars under different curing times ranging from 2 to 120 h and different thermal treatment temperatures such as 90, 150, and 200°C were examined. The effectiveness of OB and SF on the physical features, compressive strength (CS), and micro‐structural of the geopolymers were characterized. Results demonstrated that the peak CSs were acquired in 96 h at 90 and 150°C heat treatment temperatures, while the highest CSs were acquired in 72 h for specimens subjected to 200°C heat treatment. Reduces in CSs were detected when the curing time exceeded the ideal limit. OB‐based geopolymer was found to be stable with SF and there was a linear relationship between SF substitution ratio and CS. The density of the mortar pieces decreased with increasing thermal curing hours. Devolving on the thermal temperature and curing time, the microstructures became more compact and microvoids and cracks decreased. It was observed that SF substitution reduced the total pore size of the geopolymers and allowed the pore structure size to be reduced. The results obtained from the study are expected to encourage the utilize of industrial wastes and new binders in the manufacture of geopolymers.
Total intravenous anaesthesia maintenance with an infusion of butorphanol, ketamine and guaifenesin in two greater one‐horned rhinoceros (Rhinoceros unicornis)
Authors: Vonfeld Irène , Leclerc Antoine , Zilberstein Luca , Pérot Maïalen , Avril Sandra , Lamglait Benjamin , Ordonneau Dorothée , Thorel Milan , Ménagerie La , Hennet Philippe , Brisson Lucie 
Published: August 2024

AbstractThis report describes the use of an ultrapotent, opioid‐free anaesthesia with an infusion of butorphanol, ketamine and guaifenesin in two captive adult male greater one‐horned rhinoceros (Rhinoceros unicornis). Animals were premedicated intramuscularly with azaperone (0.05 mg/kg), butorphanol tartrate (0.05 and 0.02 mg/kg, respectively) and an α2‐agonist (detomidine 0.02 mg/kg and medetomidine 0.01 mg/kg, respectively). Once sternolaterally recumbent, rhinoceros were induced with intravenous ketamine (0.02 and 0.05 mg/kg, respectively) and midazolam (7.0 and 8.0 μg/kg, respectively). Intravenous infusions of guaifenesin (15.1 and 25 mg/kg/h, respectively) and of ketamine (22.5 and 29.1 μg/kg/h, respectively) and butorphanol (15.7 and 20.3 μg/kg/h, respectively), allowed stable anaesthesia maintenance for dental procedures to take place. Supplemental boluses of ketamine and α2‐agonist were required during noxious stimulation in both cases. Animals were reversed with intramuscular atipamezole (0.07–0.08 mg/kg) and naltrexone (0.06–0.08 mg/kg), with or without flumazenil (0.10 μg/kg), allowing smooth and quick recovery.
Common bile duct obstruction caused by synthetic linear foreign material in a dachshund
Authors: Zurbuchen Sarah , Stone Colin , Chambers Aidan , Womble Mandy , Mathews Kyle G. 
Published: August 2024

AbstractA 1‐year‐old, female, spayed dachshund presenting with clinical signs associated with cholangiohepatitis and cholangitis was found to have synthetic linear foreign material causing a common bile duct obstruction. The patient underwent a cholecystectomy, and foreign material was removed from the common bile duct via retrograde flushing into the duodenal papilla and manual retrieval. At the 6‐month post‐operative follow up visit, the patient had an improved cholestatic hepatopathy, with only a mild alkaline phosphatase elevation, moderate dilation of the common bile duct on ultrasonography, and was doing clinically well at home. 8 months post‐operatively, the patient re‐presented for an episode of septic cholangiohepatitis, with linear foreign material visualised within a dilated common bile duct on ultrasound. This episode was medically managed and was resolved with a 2‐week course of antibiotics. 1.5 years post‐operatively, the patient is doing clinically well, but continues to have persistent, moderate elevations of alanine transaminase and alkaline phosphatase.
Prognostic significance of T3b in papillary thyroid carcinoma: Appropriateness of classifying T3bN0M0 in patients aged 55 years or older into stage II
Authors: Ito Yasuhiro , Miyauchi Akira , Kawakami Makoto , Kihara Minoru , Miya Akihiro 
Published: August 2024

AbstractBackgroundPapillary thyroid carcinoma (PTC) often extends to adjacent organs. According to the 8th Tumor‐Node‐Metastasis Classification, extension to the strap muscles was graded as T3b. We investigated the prognostic impact of T3b and the appropriateness of T3b in patients aged ≥55 years who were classified as stage II.MethodsWe enrolled 7811 patients with M0 PTC who underwent initial surgery at the Kuma Hospital (Kobe, Japan) between January 2007 and December 2016. Tumor extension was divided into T3b, T4a1 (extension to the tracheal adventitia, tracheal cartilage, esophageal muscle layer, recurrent laryngeal nerve, cricothyroid, and inferior constrictor muscles), and sT4a2 (extension to the subcutaneous soft tissues, tracheal mucosa, esophageal mucosa, internal jugular vein, brachiocephalic vein, larynx, pharynx, and sternocleidomastoid muscle).ResultsIn patients ≥55 years, the local recurrence‐free survival (LR‐FS), distant recurrence‐free survival (DR‐FS), and cause‐specific survival (CSS) rates of T3bN0M0 were significantly poorer than those of T1/T2N0M0 but did not significantly differ from those of T3aN0M0. The LR‐FS, DR‐FS, and CSS rates of T3b stage II patients did not differ from those of T4a1 stage III patients but were significantly better than those of T4a2 stage III patients. T3b was an independent predictor of local recurrence and distant recurrence but not of death due to carcinoma in the multivariate analysis. In patients aged <55 years with M0 PTC, T3b had no prognostic value in both analyses.ConclusionsT3bM0 patients are appropriate to be classified as stage II in patients ≥55 years but be kept in stage I in patients <55 years.
Functionalization of Si‐ and Al‐Based Materials with Phosphorus Dendrimers and their Properties
Authors: Caminade Anne‐Marie 
Published: August 2024

AbstractThe interactions of dendrimers having a phosphorus atom at each branching point, of type poly(phosphorhydrazone) (PPH), with different types of materials based on silicon and aluminum are reviewed. These dendrimers can be used for the functionalization of solid surfaces at the nanoscale, either by covalent immobilization, or by electrostatic interactions, especially for constructing perfectly controlled multi‐layers by layer‐by‐layer (LbL) deposit. The properties of such hybrid materials as chemical sensors, as very sensitive biological sensors, as well as substrates for the growing of cells are described. The PPH dendrimers can also be embedded inside materials. The resulting hybrid materials have been used for the capture of pollutants, in particular CO2 in air and chromate and methylene blue in waste water.
Anti-Sexism as Weaponized Discourse Against Muslim Immigration: A View from Social Psychology
Authors: Van Oost Pascaline , Klein Olivier , Yzerbyt Vincent 
Published: August 2024

AbstractFor fifty years, the Western world has witnessed a noticeable decrease in overt expressions of prejudice, reflecting evolving social norms, whereby racism is perceived as something immoral and is often illegal. At the same time, it is clear that racist prejudice persists, largely rooted in historical and cultural legacies like colonialism. Because our egalitarian norms make prejudice undesirable, prejudice is predominantly conveyed in subtle ways, and tends to be rationalized (Crandall & Eshleman, 2003). In this context, gender equality ideology has been brought to the debate to legitimize a racist discourse against Muslims across different European countries. Politicians who hardly ever showed any sympathy for or even blatantly opposed gender-rights movements are found to profess gender-based arguments to support an anti-Muslim agenda. Threatened by purportedly sexist and illiberal Islam, these leaders argue that the ‘European egalitarian culture’ must be protected and reasserted. This opportunistic support for the gender movement on behalf of politicians has been pointed out by several authors (e.g., Delphy, 2006; Farris, 2017). In the present chapter, we explore social psychological perspectives that have been developed to tackle this paradox. In particular, we focus on the concept of ‘ideological malleability’, as introduced by Knowles and colleagues in 2009.
Dreamers Moms and Their Struggle for Legal Reunification: Maternal Acts of Public Disclosure as a Form of Constructive Resistance
Authors: Busse Erika , Montes Veronica 
Published: August 2024

AbstractMaternal activism is a long tradition in Latin America. Its research focuses on how women mobilize their identity as mothers to take the streets to reclaim their rights, their children’s, and their families’, and ultimately to resist the actions of the State. However, how does this maternal activism manifest itself when motherhood and deportation intersect? Drawing on our ongoing ethnographic research with Dreamers Moms (DM), a grassroots organization in Tijuana, Mexico composed by Mexican women, we argue that the acts displayed by members of DM are part of an ample repertoire of what Orozco Mendoza (2019) refers to as “maternal acts of public disclosures” through which these women engage in a form of constructive resistance. Rather than trying to change the world order and, particularly, the unjust U.S. migration policy, these women, by performing these acts, seek to achieve two goals: to fight against being stripped of their humanity and dignity as they were violently expelled from the U.S. due to their deportation, and to avoid the invisibility and otherization of their subjectivity once they become deported mothers.