bluuebunny/crossref_metadata_2025_split huggingface dataset:
A strategy to study pathway cross-talks of cells under repetitive exposure to stimuli
Authors: Fu Yan , Jiang Xiaoshan , Zhang Hang , Xing Jianhua 
Published: June 2013

AbstractBackgroundCells are subject to fluctuating and multiple stimuli in their natural environment. The signaling pathways often crosstalk to each other and give rise to complex nonlinear dynamics. Specifically repetitive exposure of a cell to a same stimulus sometime leads to augmented cellular responses. Examples are amplified proinflammatory responses of innate immune cells pretreated with a sub-threshold then a high dose of endotoxin or cytokine stimulation. This phenomenon, called priming effect in the literature, has important pathological and clinical significances.ResultsIn a previous study, we enumerated possible mechanisms for priming using a three-node network model. The analysis uncovered three mechanisms. Based on the results, in this work we developed a straightforward procedure to identify molecular candidates contributing to the priming effect and the corresponding mechanisms. The procedure involves time course measurements, e.g., gene expression levels, or protein activities under low, high, and low + high dose of stimulant, then computational analysis of the dynamics patterns, and identification of functional roles in the context of the regulatory network. We applied the procedure to a set of published microarray data on interferon-γ-mediated priming effect of human macrophages. The analysis identified a number of network motifs possibly contributing to Interferon-γ priming. A further detailed mathematical model analysis further reveals how combination of different mechanisms leads to the priming effect.ConclusionsOne may perform systematic screening using the proposed procedure combining with high throughput measurements, at both transcriptome and proteome levels. It is applicable to various priming phenomena.
Tolerance to alternative cyclooxygenase‐2 inhibitors in nonsteroidal anti‐inflammatory drug hypersensitive patients
Authors: Malskat Wendy SJ , Knulst André C , Bruijnzeel‐Koomen Carla AFM , Röckmann Heike 
Published: June 2013

AbstractBackgroundNon‐steroidal anti‐inflammatory drugs (NSAIDs) frequently cause adverse drug reactions. Many studies have shown that drugs which selectively inhibit the cyclooxygenase‐2 enzyme (COX‐2) are safe alternatives in the majority of patients. However, hypersensitivity reactions to COX‐2 inhibitors have been published. Hardly any data are available regarding the safety of alternatives in case of COX‐2 inhibitor hypersensitivity. We aimed to investigate the tolerance to COX‐2 inhibitors in patients with non‐selective NSAID hypersensitivity. Furthermore, in COX‐2 hypersensitive patients tolerance of a second COX‐2 inhibitor was investigated.MethodsWe retrospectively analyzed 91 patients with proven non‐selective NSAID hypersensitivity that underwent oral challenges with a COX‐2 inhibitor. Patients with intolerance to the first challenged COX‐2 inhibitor received a second challenge with a different COX‐2 inhibitor.Results19 out of 91 (21%) patients had a positive reaction to the first oral challenge with a COX‐2 inhibitor. 14 of them underwent a second challenge with a different COX‐2 inhibitor and 12 (86%) did not react.ConclusionsA relatively high percentage (21%) of the non‐selective NSAID hypersensitive patients did not tolerate a COX‐2 inhibitor and oral challenge is advised prior to prescription of a COX‐2 inhibitor. For the majority of patients reacting to a COX‐2 inhibitor an alternative can be found.
Mechanical ventilation worsens abdominal edema and inflammation in porcine endotoxemia
Authors: Lattuada Marco , Bergquist Maria , Maripuu Enn , Hedenstierna Göran 
Published: June 2013

Abstract
Introduction
We hypothesized that mechanical ventilation per se increases abdominal edema and inflammation in sepsis and tested this in experimental endotoxemia.

Methods
Thirty anesthetized piglets were allocated to one of five groups: healthy control pigs breathing spontaneously with continuous positive pressure of 5 cm H2O or mechanically ventilated with positive end-expiratory pressure of 5 cm H2O, and endotoxemic piglets during mechanical ventilation for 2.5 hours and then continued on mechanical ventilation with positive end-expiratory pressure of either 5 or 15 cm H2O or switched to spontaneous breathing with continuous positive pressure of 5 cm H2O for another 2.5 hours. Abdominal edema formation was estimated by isotope technique, and inflammatory markers were measured in liver, intestine, lung, and plasma.

Results
Healthy controls: 5 hours of spontaneous breathing did not increase abdominal fluid, whereas mechanical ventilation did (Normalized Index increased from 1.0 to 1.6; 1 to 3.3 (median and range, P < 0.05)). Endotoxemic animals: Normalized Index increased almost sixfold after 5 hours of mechanical ventilation (5.9; 4.9 to 6.9; P < 0.05) with twofold increase from 2.5 to 5 hours whether positive end-expiratory pressure was 5 or 15, but only by 40% with spontaneous breathing (P < 0.05 versus positive end-expiratory pressure of 5 or 15 cm H2O). Tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in intestine and liver were 2 to 3 times higher with mechanical ventilation than during spontaneous breathing (P < 0.05) but similar in plasma and lung. Abdominal edema formation and TNF-α in intestine correlated inversely with abdominal perfusion pressure.

Conclusions
Mechanical ventilation with positive end-expiratory pressure increases abdominal edema and inflammation in intestine and liver in experimental endotoxemia by increasing systemic capillary leakage and impeding abdominal lymph drainage.
Organic maturity, elastic properties, and textural characteristics of self resourcing reservoirs
Authors: Zargari Saeed , Prasad Manika , Mba Kenechukwu C. , Mattson Earl D. 
Published: June 2013

Organic-rich rocks have long been recognized as source rocks for clastic reservoirs, but more recently they have gained importance as reservoirs. However, the processes of kerogen maturation and hydrocarbon transport and storage are still poorly understood. Some empirical relations have been developed to relate the increase in elastic modulus with increasing maturity. A systematic study of the cause for this increase in elastic modulus is still lacking, and information about seismic and mechanical properties of kerogen and its alteration products is scarce. Consequently, any rock models must rely on anecdotal or extrapolated data about various types of kerogen. Our experiments address this paucity of data by grain-scale modulus measurements coupled with careful field emission scanning electron microscopy (FESEM) microstructural assessments on organic rich Bakken formation shale samples with a range of maturities. Carefully acquired and detailed FESEM images help to understand the microstructural controls on the reduced (nanoindentation) Young’s modulus of minerals, clay particles, and kerogen matter with maturity in naturally matured shales. Using hydrous pyrolysis, we further investigate the cause for change in modulus with maturity and the mobility of the pyrolized organic matter. In naturally matured shale samples, we find a direct relationship between the reduced Young’s modulus and the total organic content or hydrogen index. Significant lowering of Young’s modulus is observed after hydrous pyrolysis due to bitumen generation. We measured modulus of the extruded bitumen to be less than 2 GPa. The presence of bitumen comingled with the organic matter also reduces its modulus, in excess of 30%. These results are critical to help understand how organic-rich sediments evolve with burial and maturation. The modulus measurements can be used for modeling modulus variations during maturation.
From cigarreras to indignados: Spectacles of scale in the CSA La Tabacalera of Lavapiés, Madrid
Authors: Feinberg Matthew I. 
Published: June 2013

Abstract
In Lavapiés, Madrid, the Centro Social Autogestionado La Tabacalera (The Tobacco Factory Self-Managed Social Centre) recalls the prevalence of the cigarrera in the popular theatre of the nineteenth and early twentieth centuries while continuing the neighbourhood’s contemporary tradition as one of the epicentres in Madrid for grass-roots activist politics. While these connections activate cultural circuits of meaning that simultaneously evoke local and national imaginaries, they have made La Tabacalera a site where the intersection of the scales of the local, the urban and even the national has been a key component of the convergence of culture and space that urban theorist Henri Lefebvre would call lived space. Through a close reading of a series of cultural events held at La Tabacalera in 2010 and an analysis of the discourses of scale found in the ‘Dossier de Renovación del Convenio’ (‘Renewal Agreement Dossier’) from 2011, the present article will demonstrate how cultural production at the scale of the urban has been employed as a means of resisting spatial and cultural commodification at a range of other scales.
Editorial: Madrid and urban cultural studies
Authors: Fraser Benjamin 
Published: June 2013

Abstract
This Editorial opens the special issue of the International Journal of Iberian Studies titled ‘Reading Madrid: Perspectives from Urban Cultural Studies’ by suggesting mobility as a trope that is just as relevant to close textual readings and to a wider understanding of Madrid’s cultural production as it is to questions of disciplinary and interdisciplinary research, more broadly considered. Appropriately, given the objective at hand, the impetus for this move is sparked by a textual analysis – of Madrid’s presentation throughout the opening sequence from director Pedro Lazaga’s 1965 film La ciudad no es para mí.
The garden at night: Revisiting Madrid’s public landscapes in Valle-Inclán’s Luces de Bohemia and Baroja’s Noches del Buen Retiro
Authors: Frost Daniel 
Published: June 2013

Abstract
If nineteenth-century notions of order and decorum reached something of an apotheosis in realist representations of Madrid’s gardens, works such as Valle-Inclán’s Luces de Bohemia (1924) and Pío Baroja’s Las noches del Buen Retiro (1934) present gardens as an image of twentieth-century urban society’s excesses and limits. Valle-Inclán’s nocturnal garden with prostitutes and shattered glass suggests the bleakness of protagonist Max Estrella’s social orbit, while Pío Baroja’s vision of Madrid’s Jardines del Buen Retiro pleasure garden conceals hostility and alienation under the guise of nostalgia and social refinement. Both gardens symbolize the ‘degeneration’ of what Jo Labanyi has described as the object of the modernizing state: to define the private self through the assumption of publicly defined roles.
Juggling aesthetics and surveillance in paradise: Ecuadorians in Madrid’s Retiro Park
Authors: Masterson-Algar Araceli 
Published: June 2013

Abstract
The literature on parks and recreation has traditionally employed definitions of parks as products, rather than processes tied to economic, political and social dynamics that comfortably exceed park boundaries. As a cultural process, mental and physical, local and global, Madrid’s emblematic park of El Retiro is at the intersection of personal choices/desires and constructions of race, class, gender and nation, always articulated through dynamics of power. This article examines the significance of Ecuadorian immigrant gatherings in El Retiro between 2000 and 2003, focusing on the entwinement between the municipality’s decisions over the park’s form and use, and larger patterns of injustice occurring at a variety of scales, as the city (re-)positions itself vis-à-vis current methods of capital accumulation. An analysis of El Retiro’s recently constructed Bosque del Recuerdo, a memorial to the victims of the bomb attacks in Madrid’s trains on 11 March 2004, reveals the ties between the expulsion of Ecuadorians from El Retiro and the pseudo-sacralization of Ecuadorian casualties following the bombings. Through an in-depth analysis of the space for this ‘memorial’, as form and content, this article unearths the mutual constituencies of El Retiro as lived and imagined, local and global, and central in the histories of Madrid’s Ecuadorian residents.
Revision in Cemented and Cementless Infected Hip Arthroplasty
Authors: Cherubino Paolo , Puricelli Marco , D’Angelo Fabio 
Published: June 2013

Infection is a frequent cause of failure after joint replacement surgery. The infection rate after total hip arthroplasty (THA) has been reduced to 1-2% in the last years. However, it still represents a challenging problem for the orthopedic surgeon.Difficulty of therapeutic approach, and poor functional outcomes together with length of treatment and overall cost are the main burden of this issue. Even the diagnosis of an infected hip could be challenging although it is the first step of an accurate treatment. At the end, many cases require removing the implants. Afterwards, the treatment strategy varies according to authors with three different procedures: no re-implantation, immediate placement of new implants or a two-stage surgery re-implantation.Based on the most recently systematic review there is no suggestion that one- or two-stage revision methods have different re-infection outcomes.The two-stage implant-exchange protocol remains the gold standard. It is considered as the most efficacious clinical approach for the treatment of periprosthetic infection, especially in patients with sinus tracts, swelling, extended abscess formation in depth and infection of Methicillin ResistantStaphylococcus Aureus(MRSA), and other multidrug-resistant bacteria as reported in recent consensus documents.
Economical Analysis on Prophylaxis, Diagnosis, and Treatment of Periprosthetic Infections
Authors: Fernandez-Fairen Mariano , Torres Ana , Menzie Ann , Hernandez-Vaquero Daniel , Fernandez-Carreira José Manuel , Murcia-Mazon Antonio , Guerado Enrique , Merzthal Luis 
Published: June 2013

The economic burden of periprosthetic infections is enormous, but the number of economic studies dealing with this issue is very scarce. This review tries to know the economic literature existing, assess the value of current data, and recognize the less costly and more effective procedures for prevention, diagnosis and treatment of periprosthetic infections.Forty five studies meeting the inclusion criteria and adhering to the quality criteria used were carefully analyzed to extract the economic data of relevance in evaluating the magnitude of problem and the more cost-effective solutions. However, because the heterogeneity and the low-quality of most of these studies meta-analytical technique has not been possible. Instead, the studies have been reviewed descriptively.Optimizing the antibiotic use in the prevention and treatment of periprosthetic infection, combined with systemic and behavioral changes in the operating room; detecting and treating the high-risk groups; a quick, simple, reliable, safe, and cost-effective diagnosis, and the rationale management of the instituted infection, specifically using the different procedures according to each particular case, could allow to improve outcomes and produce the highest quality of life for patients and the lowest economic impact. Nevertheless, the cost effectiveness of different interventions to prevent and to treat the periprosthetic infection remains unclear.
Differences on the prevalence of cervical HPV between Lithuania and Belarus
Authors: Gudleviciene Zivile , Kanopiene Daiva , Didziapetriene Janina , Smolyakova Raisa , Gutkovskaya Ekaterina , Zhukovec Alexander , Kostevich Galina 
Published: June 2013

Abstract
In some countries the cervical cancer incidence and mortality rates are much higher compared to the European average. The differences of HPV and its type prevalence between countries and regions influence cervical cancer incidence and mortality. Regarding the differences in cervical cancer incidence and mortality in Lithuania and Belarus, the aim of this study was to describe HPV infection level and HPVs type distribution among two study groups of patients with moderate or severe cervical intraepithelial neoplasia (CIN2-3) and cervical cancer. Our data shows that 74.2% [95% CI: 63.64÷84.76] of Lithuanian patients with cervical cancer and 85.6% [95% CI: 85.53÷92.85] of the study group with CIN2-3 were HPV positive, while in the study groups of Belarusian patients HPV infection was detected in 92.6% [95% CI, 74.25÷98.71] and 65.4% [95% CI, 44.36÷82.06] cases respectively. HPV 16 was the most prevalent type in Lithuanian as well as in Belarusian patients of the study groups. HPV 18 in Lithuanian patients of the study group with cervical cancer was identified in 10.2% [95% CI: 1.73÷18.67] and in the study group with CIN2-3 — in 2.6% [95% CI: 0.95÷6.15] of cases. HPV 18 was not detected in Belarusian patients of both groups.
New Therapeutic Options for Allergic Rhinitis: Back to the Future with Intranasal Corticosteroid Aerosols
Authors: Carr Warner W. 
Published: June 2013

Background Under current guidelines, intranasal corticosteroids (INSs) are considered the most effective first-line therapy to improve allergic rhinitis (AR) symptoms and burden of disease. In the late 1980s–1990s, chlorofluorocarbon (CFC)–propelled corticosteroid aerosol nasal sprays formed the standard of care for the treatment of AR. Because of environmental concerns, CFC aerosols were gradually phased out, and aqueous INS formulations of nasal sprays became the standard of care. Although many aqueous INS sprays are available, specific product-related factors can reduce patient adherence to an INS and subsequently reduce treatment efficacy. The purpose of this paper was to review the evolution of AR therapeutics and drug devices and how it may have an effect on patient adherence/compliance and patient satisfaction with current available therapies and show the unmet need to improve INS delivery systems. Methods Although aqueous INSs are effective and well tolerated, use in some patients may be compromised because of patient sensory perception and device preference. A historical review of the evolution of intranasal delivery of INSs was undertaken to provide further insight into improving treatment options for patients with AR. Results Although the various approved INSs appear to be equivalent in terms of reducing AR disease burden, the method in which an INS is delivered to a patient has significant bearing on the overall success of each specific drug product. Conclusion Hydrofluoroalkane-propelled INS drug products offer a back-to-the-future delivery approach that may be further tailored to the individual patient's needs. Past experiences and the development of new devices are paving the way toward further therapy choices, ultimately affording health care providers access to the most effective treatments for patients with AR.
Green Rhetoric in Blackshirts: Italian Fascism and the Environment
Authors: Armiero Marco , Graf von Hardenberg Wilko 
Published: June 2013

Abstract
In comparison with the significant historiographical work on the German case, specifically on Nazi environmental policies and ideology, studies on such issues for other Fascist regimes are still rather rare. This article attempts partially to fill this gap, at least as regards the Italian case, offering a general overview of the Fascist regime and its environmental politics and narratives. Analysing how Fascists appropriated Italian landscapes through both discourses and concrete policies, this paper examines the construction of a Fascist nature as a rhetorical, symbolic and geographical space. In particular, this essay explores the combined process of appropriation and expropriation through the analysis of two diverse but intertwined issues: firstly, Fascist rural ideology as a narrative on the mutual constituency of nature and people and secondly, the creation of the first Italian national parks, their successes and failures as institutions of nature conservation and their role as symbols of the nature/society divide. While blending the ideas of race, landscape, history, modernity and ruralism, Fascists shaped both the national environment and general ideas about nature in a narrative which affected the very object of the narration - that is, nature itself.Â
Is It a Sialolithiasis or Tooth?
Authors: Senturk Mehmet Fatih , Yakar Elif Naz , Oztas Bengi 
Published: June 2013

ABSTRACT

Objectives
The aim of this study was to present careful evaluation of the clinical and radiological findings of submandibular salivary gland pathologies and its importance to diagnose.

Case report
Presented here is a case report of a 65-year-old male patient who had a submandibular sialolith. The sialolith was removed with intraoral approach and no postoperative complications were noted. Radiopaque lesion was similar to premolar tooth according to radiographic examinations performed by use of panoramic and occlusal radiography.

Conclusion
Reported here is a case of submandibular sialolith which was diagnosed clinically and radiographically and treated with no postoperative complications.

How to cite this article
Inceoglu B, Senturk MF, Yakar EN, Oztas B. Is It a Sialolithiasis or Tooth?. Int J Experiment Dent Sci 2013;2(1):50-52.
Systematic Review of Interventions Used in or Relevant to Occupational Therapy for Children With Feeding Difficulties Ages Birth–5 Years
Authors: Howe Tsu-Hsin , Wang Tien-Ni 
Published: June 2013

AbstractResearch articles on the effectiveness of feeding interventions for infants and young children were identified, appraised, and synthesized. Thirty-four studies met the inclusion criteria and were reviewed. Three broad intervention themes regarding feeding approaches were identified on the basis of their theoretical orientations. These three feeding approaches were (1) behavioral interventions, (2) parent-directed and educational interventions, and (3) physiological interventions. Synthesis of the evidence suggested that various feeding approaches may result in positive outcomes in the areas of feeding performance, feeding interaction, and feeding competence of parents and children. This synthesis of empirical evidence supporting interventions for feeding problems provides a foundation for future research to define the types of outcomes that can be expected for children with different diagnoses or functional impairments and to develop best practice guidelines.
Research Utilization and Evidence-Based Practice in Occupational Therapy: A Scoping Study
Authors: Thomas Aliki , Law Mary 
Published: June 2013

Abstract
Many articles have been written on the barriers to and facilitators of the use of evidence in practice in nursing and medicine, but to date no extensive review has been published of the literature on evidence-based practice (EBP) supports in occupational therapy. This article presents the results of a scoping review that examined factors that support the integration of research into practice. A review of 69 articles revealed four themes: (1) attitudes toward, perceptions of, confidence in, and use of research and EBP; (2) factors that support the use of research in practice; (3) effects of interventions targeting changes in knowledge, attitudes, skills, behaviors, and evidence-based practices; and (4) identification of the processes involved in the acquisition of EBP skills and their application in clinical practice. A process that integrates client-centered practice, structured reflection, case application, and peer consultations within a scholarship of practice model facilitates occupational therapists’ evaluation and integration of research evidence.