bluuebunny/crossref_metadata_2025_split huggingface dataset:
Charles Koechlin et l’amour des stars. L’acteur et son jeu comme moteur expressif d’une musique de cinéma idéale
Authors: Duchesneau Michel 
Published: May 2015

Dans les années 1930, le compositeur Charles Koechlin (1867-1950) se découvre une passion pour le cinéma parlant ; outre ses articles sur le sujet, il a laissé des notes personnelles et des projets de scénarios et de musiques de film, allant jusqu’à concevoir des scénarios cinématographiques pour une musique qui n’existe pas et une musique pour des images qui n’existent pas — mais qui, dans son imaginaire, sont à la fois compatibles et de la plus haute tenue artistique. À cette passion s’ajoute celle qu’il éprouve pour les stars du cinéma et plus particulièrement pour l’actrice Lilian Harvey (1906-1968) ; Koechlin sublimera cet amour en musique et composera plus d’une centaine de pièces réunies dans les deux Albums de Lilian et dans Le portrait de Daisy Hamilton. Cet article tente une analyse des trois éléments cinématographiques — mouvement, ligne et expression — que Koechlin s’attache à transposer en musique dans ses « sketches pour un film imaginaire », et montre qu’au-delà des principes esthétiques qui l’animent, le compositeur trouve dans l’image sonore un matériau d’un dynamisme, d’une plasticité et d’une sensualité qu’aucune autre forme d’inspiration n’avait pu lui donner jusque-là.
Azimuthal inhomogeneity in the MHD waveguide in the outer magnetosphere
Authors: Mazur V. A. , Chuiko D. A. 
Published: May 2015

AbstractGeomagnetic field and plasma inhomogeneities in the outer equatorial part of the magnetosphere create a channel with low Alfvén speeds which spans from the nose to the far flanks of the magnetosphere, in both the morning and the evening sectors. This channel plays the role of a waveguide for fast magnetosonic waves. The waveguide eigenmodes and corresponding Alfvén resonance (field line resonance) regions are directly related to geomagnetic pulsations Pc3 and Pc5. U‐shaped model of the waveguide allows for full analytical investigation of waveguide eigenmodes. Quantities such as mode wave numbers, group velocities, and their energy density distribution are found as functions of coordinate along the waveguide. The linkage of the waveguide magnetosonic oscillation energy to the Alfvén waves in the vicinity of the field line resonance deeper inside the magnetosphere is investigated, and corresponding energy leakage coefficient is found. Thus, the influence of longitudinal (i.e., azimuthal) waveguide inhomogeneity on wave propagation is analytically investigated. Obtained results can be used for interpretation of the observed wave power distribution in the frequency bands of geomagnetic pulsations Pc3 and Pc5, as well as for explanation of their spectral properties in the outer magnetosphere.
Dynamic rupture models of earthquakes on the Bartlett Springs Fault, Northern California
Authors: Lozos Julian C. , Harris Ruth A. , Murray Jessica R. , Lienkaemper James J. 
Published: May 2015

AbstractThe Bartlett Springs Fault (BSF), the easternmost branch of the northern San Andreas Fault system, creeps along much of its length. Geodetic data for the BSF are sparse, and surface creep rates are generally poorly constrained. The two existing geodetic slip rate inversions resolve at least one locked patch within the creeping zones. We use the 3‐D finite element code FaultMod to conduct dynamic rupture models based on both geodetic inversions, in order to determine the ability of rupture to propagate into the creeping regions, as well as to assess possible magnitudes for BSF ruptures. For both sets of models, we find that the distribution of aseismic creep limits the extent of coseismic rupture, due to the contrast in frictional properties between the locked and creeping regions.
Effects of the Fe3+ spin transition on the equation of state of bridgmanite
Authors: Mao Zhu , Lin Jung‐Fu , Yang Jing , Inoue Toru , Prakapenka Vitali B. 
Published: May 2015

AbstractWe have investigated the equation of state of Fe‐bearing bridgmanite, (Mg0.9Fe0.1)SiO3, using synchrotron X‐ray diffraction in diamond anvil cells up to 125 GPa and 300 K. Combined with previous synchrotron Mössbauer spectroscopy results, we have found that the occurrence of the low‐spin Fe3+ in the octahedral sites (B site) of bridgmanite has produced a 0.5(±0.1)% reduction in the unit cell volume at 18–25 GPa and has increased the isothermal bulk modulus to 284(±4) GPa, consistent with recent theoretical calculations. Together with literature results, we note that the addition of Fe can cause an increase in the density, bulk modulus, and bulk sound velocity in both Al‐free and Al‐bearing bridgmanite at lower mantle pressures. The presence of Fe3+ in the B site of bridgmanite can further enhance this increase. The observed spin transition of B site Fe3+ in bridgmanite is thus important for understanding the density and velocity structures of the lower mantle.
Propagation characteristics of young hot flow anomalies near the bow shock: Cluster observations
Authors: Xiao T. , Zhang H. , Shi Q. Q. , Zong Q.‐G. , Fu S. Y. , Tian A. M. , Sun W. J. , Wang S. , Parks G. K. , Yao S. T. , Rème H. , Dandouras I. 
Published: May 2015

AbstractBased on Cluster observations, the propagation velocities and normal directions of hot flow anomaly (HFA) boundaries upstream the Earth's bow shock are calculated. Twenty‐one young HFAs, which have clear leading and trailing boundaries, were selected, and multispacecraft timing method considering errors was employed for the investigation. According to the difference in the propagation velocity of the leading and trailing edges, we categorized these events into three groups, namely, contracting, expanding, and stable events. The contraction speed is a few tens of kilometers per second for the contracting HFAs, and the expansion speed is tens to more than hundred kilometers per second for expanding events. For the stable events, the leading and trailing edges propagate at almost the same speed within the error range. We have further investigated what causes them to contract, expand, or stay stable by carefully calculating the thermal pressure of the young HFAs which have two distinct ion populations (solar wind beam and reflected flow). It is found that the extreme value of the sum of the magnetic and thermal pressure inside the HFAs compared with that of the nearest point outside of the leading edges is higher for expanding events and lower for contracting events, and there is no significant difference for the stable events, and the total pressure (sum of thermal, magnetic, and dynamic pressure) variation has a significant effect on the evolution for most (70%) of the HFAs, which implies that the pressure plays an important role in the evolution of young HFAs.
Spectrum of Muscle Histopathologic Findings in Forty‐Two Scleroderma Patients With Weakness
Authors: Paik Julie J. , Wigley Fredrick M. , Lloyd Thomas E. , Corse Andrea M. , Casciola‐Rosen Livia , Shah Ami A. , Boin Francesco , Hummers Laura K. , Mammen Andrew L. 
Published: May 2015

ObjectiveTo determine if distinct muscle pathologic features exist in scleroderma subjects with weakness.MethodsThis retrospective study included weak scleroderma subjects with muscle biopsies available for review. Biopsies were systematically assessed for individual pathologic features, including inflammation, necrosis, fibrosis, and acute neurogenic atrophy. Based on the aggregate individual features, biopsies were assigned a histopathologic category of polymyositis, dermatomyositis, necrotizing myopathy, nonspecific myositis, “acute denervation,” “fibrosis only,” or “other.” Clinical data analyzed included autoantibody profiles, scleroderma subtype and disease duration, Medsger muscle severity scores, creatine kinase, electromyography, and muscle magnetic resonance imaging.ResultsA total of 42 subjects (79% female and 64% diffuse scleroderma) were included in this study. Necrosis (67%), inflammation (48%), acute neurogenic atrophy (48%), and fibrosis (33%) were the most prevalent pathologic features. The presence of fibrosis was strongly associated with anti–PM‐Scl antibodies. Histopathologic categories included nonspecific myositis (36%), necrotizing myopathy (21%), dermatomyositis (7%), “acute denervation” (7%), “fibrosis only” (7%), and polymyositis (5%). Disease duration of scleroderma at the time of muscle biopsy was shorter in polymyositis than other histopathologic categories. Patients with anti–PM‐Scl and Scl‐70 antibodies also had a shorter disease duration than those with other autoantibody profiles.ConclusionNonspecific myositis and necrotizing myopathy were the most common histopathologic categories in weak scleroderma subjects. Surprisingly, nearly half of the subjects studied had histologic evidence of acute motor denervation (acute neurogenic atrophy); this has not been previously reported. Taken together, these observations suggest that a variety of pathologic mechanisms may underlie the development of myopathy in scleroderma.
Arene cis‐Diol Dehydrogenase‐Catalysed Regio‐ and Stereoselective Oxidation of Arene‐, Cycloalkane‐ and Cycloalkene‐cis‐diols to Yield Catechols and Chiral α‐Ketols
Authors: Boyd Derek R. , Sharma Narain D. , Berberian M. Victoria , Cleij Marcel , Hardacre Christopher , Ljubez Vera , McConville Gareth , Stevenson Paul J. , Kulakov Leonid A. , Allen Christopher C. R. 
Published: May 2015

AbstractBenzene cis‐diol dehydrogenase and naphthalene cis‐diol dehydrogenase enzymes, expressed in Pseudomonas putida wild‐type and Escherichia coli recombinant strains, were used to investigate regioselectivity and stereoselectivity during dehydrogenations of arene, cyclic alkane and cyclic alkene vicinal cis‐diols. The dehydrogenase‐catalysed production of enantiopure cis‐diols, α‐ketols and catechols, using benzene cis‐diol dehydrogenase and naphthalene cis‐diol dehydrogenase, involved both kinetic resolution and asymmetric synthesis methods. The chemoenzymatic production and applications of catechol bioproducts in synthesis were investigated.magnified image
The Arteries of the Brain in Hare (Lepus europaeus Pallas, 1778)
Authors: Brudnicki Witold , Kirkiłło‐Stacewicz Krzysztof , Skoczylas Benedykt , Nowicki Włodzimierz , Jabłoński Ryszard , Brudnicki Adam , Wach Jan 
Published: May 2015

ABSTRACTResearch into course and variability of brain arteries in hare were performed on 38 adult hares of both sexes (males 23 and females 15). The arteries were filled with a synthetic latex at a constant pressure introduced with a medical syringe to the left ventricle. The source of blood supply to the brain was internal carotid arteries, whose branches formed an arterial circle of the brain, vertebral arteries, and basilar artery as the result of its anastomosis. Variability focused on a method of departure of middle cerebral arteries, which were multiple vessels in 39.5% of cases and rostral cerebellar arteries. Caudal communicating arteries in hare comprised bilateral anastomosis of internal carotid arteries and final branches of the basilar artery. It stabilized the steady flow of blood to all parts of the brain. Caudal cerebral arteries comprised final branches of the basilar artery. The largest capacity of all the arteries of the brain was observed in the main trunk of the basilar artery. The capacity of these vessels was 4.53 mm3 on average. The factor of capacity of cerebral arteries in relation to weight of the brain reaches a high value in hare. Anat Rec, 298:1774–1779, 2015. © 2015 Wiley Periodicals, Inc.
Brief Report: Cryopyrin‐Associated Periodic Syndrome Caused by a Myeloid‐Restricted Somatic NLRP3 Mutation
Authors: Zhou Qing , Aksentijevich Ivona , Wood Geryl M. , Walts Avram D. , Hoffmann Patrycja , Remmers Elaine F. , Kastner Daniel L. , Ombrello Amanda K. 
Published: May 2015

ObjectiveTo identify the cause of disease in an adult patient presenting with recent‐onset fevers, chills, urticaria, fatigue, and profound myalgia, who was found to be negative for cryopyrin‐associated periodic syndrome (CAPS) NLRP3 mutations by conventional Sanger DNA sequencing.MethodsWe performed whole‐exome sequencing and targeted deep sequencing using DNA from the patient's whole blood to identify a possible NLRP3 somatic mutation. We then screened for this mutation in subcloned NLRP3 amplicons from fibroblasts, buccal cells, granulocytes, negatively selected monocytes, and T and B lymphocytes and further confirmed the somatic mutation by targeted sequencing of exon 3.ResultsWe identified a previously reported CAPS‐associated mutation, p.Tyr570Cys, with a mutant allele frequency of 15% based on exome data. Targeted sequencing and subcloning of NLRP3 amplicons confirmed the presence of the somatic mutation in whole blood at a ratio similar to the exome data. The mutant allele frequency was in the range of 13.3–16.8% in monocytes and 15.2–18% in granulocytes. Notably, this mutation was either absent or present at a very low frequency in B and T lymphocytes, in buccal cells, and in the patient's cultured fibroblasts.ConclusionOur findings indicate the possibility of myeloid‐restricted somatic mosaicism in the pathogenesis of CAPS, underscoring the emerging role of massively parallel sequencing in clinical diagnosis.
Derivation and Internal Validation of an Expanded Cardiovascular Risk Prediction Score for Rheumatoid Arthritis: A Consortium of Rheumatology Researchers of North America Registry Study
Authors: Solomon D. H. , Greenberg J. , Curtis J. R. , Liu M. , Farkouh M. E. , Tsao P. , Kremer J. M. , Etzel C. J. 
Published: May 2015

ObjectiveCardiovascular disease (CVD) is the leading cause of mortality in rheumatoid arthritis (RA), but CV risk prediction scores derived from the general population do not accurately predict CV risk in RA patients. The goal of these analyses was to develop and internally validate an expanded CV risk prediction score for RA.MethodsStudy participants were patients with RA and no known CVD from the Consortium of Rheumatology Researchers of North America registry. Two‐thirds of the cohort were used to derive the CV risk prediction score, and one‐third for internal validation. Traditional CV risk factors were included in the base Cox regression model, and RA‐related variables were assessed in an expanded model predicting confirmed CV events. Fit and utility of the expanded model were evaluated.ResultsThe study cohort included 23,605 RA patients with 437 CV events over a median followup of 2.2 years. The RA variables found to be significant in the regression models and included in the expanded risk model were disease activity (Clinical Disease Activity Index >10 versus ≤10), disability (modified Health Assessment Questionnaire disability index >0.5 versus ≤0.5), daily prednisone use (any versus none), and disease duration (≥10 years versus <10 years). The expanded model had good fit (Hosmer‐Lemeshow goodness of fit P = 0.94) and a lower Akaike's information criterion than the base model. In the internal validation cohort, the c‐statistic for model discrimination was significantly improved from the base model to the expanded model (from 0.7261 to 0.7609; P = 0.0104). The net reclassification index of CV risk in models using a 4‐category CV risk prediction tool was 40% (95% confidence interval 37–44%).ConclusionThis newly developed, expanded risk score for CV outcomes in RA performs well and improves the classification of CV risk in comparison to a risk prediction score in which only traditional risk factors were included.
Leptin and Neutrophil‐Activating Peptide 2 Promote Mesenchymal Stem Cell Senescence Through Activation of the Phosphatidylinositol 3‐Kinase/Akt Pathway in Patients With Systemic Lupus Erythematosus
Authors: Chen Haifeng , Shi Bingyu , Feng Xuebing , Kong Wei , Chen Weiwei , Geng Linyu , Chen Jinyun , Liu Rui , Li Xia , Chen WanJun , Gao Xiang , Sun Lingyun 
Published: May 2015

ObjectiveMesenchymal stem cells (MSCs) derived from patients with systemic lupus erythematosus (SLE) exhibit enhanced senescence. Cellular senescence has been reported to be induced by several inflammatory cytokines, including interferon‐α (IFNα) and IFNγ, that are involved in the pathogenesis of SLE. We undertook this study to investigate whether the inflammatory environment in SLE could affect MSC senescence.MethodsCellular senescence was measured by staining of senescence‐associated β‐galactosidase and by expression of the cell cycle inhibitors p53 and p21. Eighty cytokines and chemokines in serum from healthy controls and patients with SLE were identified by cytokine antibody array.ResultsSLE serum promoted senescence of MSCs, which was reversed by the phosphatidylinositol 3‐kinase (PI3K)/Akt signaling inhibitor LY294002 but not by the JAK/STAT inhibitor AG490 and not by the MEK/ERK inhibitor PD98059. Cytokine antibody array analysis revealed that leptin and neutrophil‐activating peptide 2 (NAP‐2) were the 2 factors most significantly elevated in SLE serum compared with normal serum. Blockade of leptin or NAP‐2 in MSC cultures abolished SLE serum–induced senescence, while direct addition of these 2 factors could promote senescence in cultures of normal MSCs. Inhibition of PI3K/Akt signaling with LY294002 reduced leptin‐ and NAP‐2–induced senescence in MSCs.ConclusionTaken together, our data show that leptin and NAP‐2 act synergistically to promote MSC senescence through enhancement of the PI3K/Akt signaling pathway in SLE patients.
Analysis of Published Criteria for Clinically Inactive Disease in a Large Juvenile Dermatomyositis Cohort Shows That Skin Disease Is Underestimated
Authors: Almeida Beverley , Campanilho‐Marques Raquel , Arnold Katie , Pilkington Clarissa A. , Wedderburn Lucy R. , Nistala Kiran ,   on behalf of the Juvenile Dermatomyositis Research Group
Published: May 2015

ObjectiveThe Pediatric Rheumatology International Trials Organisation (PRINTO) recently published criteria for classification of patients with juvenile dermatomyositis (DM) as having clinically inactive disease. The criteria require that at least 3 of 4 conditions be met, i.e., creatine kinase level ≤150 units/liter, Childhood Myositis Assessment Scale score ≥48, Manual Muscle Testing in 8 muscles score ≥78, and physician's global assessment of overall disease activity (PGA) ≤0.2. The present study was undertaken to test these criteria in a UK cohort of patients with juvenile DM.MethodsWe assessed 1,114 patient visits for the 4 items in the PRINTO criteria for clinically inactive disease. Each visit was analyzed to determine whether skin disease was present. The Disease Activity Score (DAS) for juvenile DM was determined in 59 patients.ResultsAt 307 of the 1,114 visits, clinically inactive disease was achieved based on the 3 muscle criteria (but with a PGA of >0.2); rash was present at 65.8% of these visits and nailfold capillary abnormalities at 35.2%. When PGA ≤0.2 was one of the 3 criteria that were met, the frequency of skin signs was significantly lower (rash in 23.1% and nailfold capillary abnormalities in 8.7%). If PGA was considered an essential criterion for clinically inactive disease (P‐CID), patients with active skin disease were less likely to be categorized as having clinically inactive disease (a median DAS skin score of 0 [of a possible maximum of 9] in visits where the PGA was ≤0.2, versus a median DAS skin score of 4 in patients meeting the 3 muscle criteria [with a PGA of >0.2]; P < 0.001). Use of the P‐CID led to improvements in the positive predictive value and the positive likelihood ratio (85.4% and 11.0, respectively, compared to 72.9% and 5.1 with the current criteria).ConclusionThere was a high frequency of skin disease among patients with juvenile DM who did not meet the PGA criterion for inactive disease but met the other 3 criteria. Incorporating PGA as an essential criterion for clinically inactive disease helps prevent the misclassification of patients with active skin disease.
Molecular Subsetting of Interferon Pathways in Sjögren's Syndrome
Authors: Hall John C. , Baer Alan N. , Shah Ami A. , Criswell Lindsey A. , Shiboski Caroline H. , Rosen Antony , Casciola‐Rosen Livia 
Published: May 2015

ObjectiveSjögren's syndrome (SS) is an autoimmune disease that targets the salivary and lacrimal glands. While all patients demonstrate inflammatory infiltration and abnormal secretory function in the target tissues, the disease features, pathology, and clinical course can vary. Activation of distinct inflammatory pathways may drive disease heterogeneity. The purpose of this study was to investigate whether activation of the interferon (IFN) pathway correlates with key phenotypic features.MethodsClinical data and 1 labial salivary gland (stored frozen) were obtained from each of 82 participants (53 patients with primary SS and 29 control subjects) in the Sjögren's International Collaborative Clinical Alliance (SICCA) registry. Salivary gland lysates were immunoblotted with markers of type I or type II IFN, and patterns of IFN activity were determined by hierarchical clustering. Correlations between SS phenotypic features and IFN activity in the salivary gland were performed.ResultsA total of 58% of the SS participants had high IFN activity and differed significantly from those with low IFN activity (higher prevalence of abnormal findings on sialometry, leukopenia, hyperglobulinemia, high‐titer antinuclear antibody, anti‐SSA, and high focus score on labial salivary gland [LSG] biopsy). Three distinct patterns of IFN were evident: type I–predominant, type II–predominant, and type I/II mixed IFN. These groups were clinically indistinguishable except for the LSG focus score, which was highest in those with type II–predominant IFN.ConclusionThe SS phenotype includes distinct molecular subtypes, which are segregated by the magnitude and pattern of IFN responses. Associations between IFN pathways and disease activity suggest that IFNs are relevant therapeutic targets in SS. Patients with distinct patterns of high IFN activity are clinically similar, demonstrating that IFN‐targeting therapies must be selected according to the specific pathway(s) that is active in vivo in the individual patient.
Is STEP the future for patients requiring proctocolectomy? A new therapeutic proposal from pediatric experience
Authors: Mangray Hansraj , Ghimenton Fernando 
Published: May 2015

Key Clinical MessageWe present a pediatric case of medically unmanageable juvenile colonic polyposis, initially treated with subtotal colectomy and an ileostomy followed by a proctectomy, ileal‐J‐pouch and serial transverse enteroplasties (STEP) of the distal ileum. The STEP procedure in an adequate length was able to control stooling of our patient.
Affective commitment and future purchase intentions in the performing arts: An empirical approach
Authors: Quero María José , Ventura Rafael 
Published: May 2015

AbstractWe examine whether affective commitment can influence customers' future purchase intentions. Our empirical approach focuses on the performing arts sector in which we interviewed 927 theatregoers at the entrances or exits to 150 theatres throughout Spain. The theoretical relationship management model proposed herein provides an analysis of the role played by satisfaction, trust, and commitment in future purchase intentions. Our findings reveal that affective commitment mediates the relationship between future purchase intention and both satisfaction and trust. We discuss the theoretical and management implications of our findings and identify some possible future research directions. Copyright © 2015 ASAC. Published by John Wiley & Sons, Ltd.