bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spontaneous twin gestation in each horn of uterus didelphys complicated with unilateral preterm labor
Authors: Ozyuncu Ozgur , Turgal Mert , Yazicioglu Aslihan , Ozek Aykut 
Published: March 2014

Abstract
Uterus didelphys is one of the developmental malformations of the mullerian ducts because of non-fusion in the midline resulting in two separate uteri. Simultaneous twin gestation with each fetus in a separate horn of uterus didelphys is an extremely rare entity. Herein, we report a case with spontaneous gestations in each uterine cavity in which the course of pregnancy of the right horn was complicated by preterm labor.
Fetal presentation of Klippel-Trénaunay-Weber syndrome with massive pleural effusion and ascites
Authors: Araki Naoto , Yamada Takahiro , Morikawa Mamoru , Akimoto Takuma , Cho Kazutoshi , Minakami Hisanori 
Published: March 2014

Abstract

Background: Although fetuses with Klippel-Trénaunay-Weber syndrome (KTS) show various morphological abnormalities on imaging studies, fetal presentation with hydrops fetalis is relatively uncommon in KTS.

Case: A 28-year-old Japanese woman who had previously given birth to a healthy infant was referred to us at gestational week (GW) 22 due to huge pleural effusion and ascites. The possibility of fetal pulmonary hypoplasia prompted us to place bilateral thoracoamniotic shunts at GW 23 after extensive discussion with both parents. The bilateral shunts were effective in preventing recurrence of pleural effusion. However, ascites gradually increased and clinical signs of fetal cardiac failure necessitated cesarean section at GW 34. A male infant, weighing 4252 g at birth and 2860 g after removal of ascites, survived to the neonatal period and did not require oxygen after postnatal day 63. The infant left hospital on day 103 with a diagnosis of KTS.

Conclusion: Fetuses with KTS may present with massive pleural effusion and ascites. Thoracoamniotic shunting may be effective in such hydropic fetuses with KTS.
Electrical Behavior of Probertite by Dielectric Spectroscopy
Authors: Okutan M. , Yalçın Z. , İçelli O. , Ay F. , Boncukçuoğlu R. , Artun O. , Delipınar D. 
Published: March 2014

AbstractIn this work of the material investigation, electrical parameters, which are real part and imaginary part of modulus, dielectric constant, dissipation factor, and conductivity, in the bulk pellet of probertite sample is presented. Electrical properties were investigated via temperature and frequency dependent dielectric spectroscopy. Real and imaginary part of dielectric parameter properties of the probertite were measured at frequencies from 100 to 15M Hz in the temperature range of 25 to 150 °C. Temperature dependence of the real part of the dielectric constant suggests that these compounds exhibit strong electromagnetic absorption and broadband electrical behavior.
Serum sex hormone-binding globulin and testosterone in relation to cardiovascular disease risk factors in young men: a population-based study
Authors: Canoy D , Barber T M , Pouta A , Hartikainen A L , McCarthy M I , Franks S , Järvelin M R , Tapanainen J S , Ruokonen A , Huhtaniemi I T , Martikainen H 
Published: March 2014

ObjectiveReduced sex hormone-binding globulin (SHBG) concentration predicts insulin resistance and type 2 diabetes, but its association with cardiovascular disease (CVD) risk is unclear. We examined the association between SHBG and cardiovascular risk factors, independently of total testosterone (TT), in young men.DesignObservational, cross-sectional study.SettingGeneral community.ParticipantsThe study included 2716 men aged 31 years in the Northern Finland Birth Cohort in 1996 with clinical examination data and fasting blood samples.Outcome variablesBlood pressure (BP), lipids and C-reactive protein (CRP) as biological CVD risk markers.ResultsSHBG concentration was significantly and inversely related to systolic and diastolic BP, triglycerides and CRP, but positively to HDL cholesterol after adjusting for insulin, BMI, waist circumference, smoking, education and physical activity (allP<0.05). These linearly graded associations persisted with additional adjustment for TT. SHBG was significantly associated with total cholesterol only with adjustment for covariates and TT (P<0.05). The direction and magnitude of associations between TT and risk factors were variable, but further adjustment for insulin, adiposity and SHBG showed positive associations between TT and BP, total and LDL-cholesterol and triglycerides and an inverse association with CRP (allP<0.05), but its relation with HDL-cholesterol was no longer significant.ConclusionsIn this cohort of young adult men, higher SHBG concentration was associated with a more favourable CVD risk profile, independently of TT. SHBG concentration modified the associations of TT with CVD risk factors.
A Novel Cell Death Gene Acts to Repair Patterning Defects in Drosophila melanogaster
Authors: Tanaka Kentaro M , Takahashi Aya , Fuse Naoyuki , Takano-Shimizu-Kouno Toshiyuki 
Published: March 2014

Abstract
Cell death is a mechanism utilized by organisms to eliminate excess cells during development. Here, we describe a novel regulator of caspase-independent cell death, Mabiki (Mabi), that is involved in the repair of the head patterning defects caused by extra copies of bicoid in Drosophila melanogaster. Mabiki functions together with caspase-dependent cell death mechanisms to provide robustness during development.
Investigation of a recombinant SMN protein delivery system to treat spinal muscular atrophy
Authors: Anderton Ryan , Meloni Bruno , Mastaglia Frank , Boulos Sherif 
Published: March 2014

AbstractSpinal muscular atrophy (SMA), the most common genetic cause of infant death, is a neurodegenerative disorder affecting motor neurons. SMA results from a loss in full-length survival of motor neuron (SMN) protein due to deletions/mutations in the SMN1 gene. In this study, we assessed the ability of cell-penetrating peptides (CPP) to deliver recombinant SMN protein to cultured neurons as a prelude for a potential therapeutic to treat SMA. Firstly, we confirmed that E. coli produced recombinant GFP protein fused to TAT (YGRKKRRQRRR; TAT-GFP) transduced rat cortical neurons in a concentration dependent manner. However, due to low yields of recombinant TATSMN protein obtainable from E. coli, we investigated the potential of a modified TAT (TATκ: YARKAARQARA) or R9 (RRRRRRRRR) peptide downstream of the fibronectin (FIB) secretory signal peptide to generate recombinant CPP-fused SMN protein. While U251 cells transduced with an adenoviral vector expressing CMV-FIB-TATκ-SMN secreted recombinant TATκ-SMN protein, we did not detect TATκ-SMN protein transduction of cortical neurons. Further, purified TATκ-SMN was unable to transduce SH-SY5Y cells, nor block apoptosis following LY294002 treatment of these cells. Our findings indicate that TATκ is not a suitable CPP to deliver SMN protein to neurons. Nonetheless, we have developed a novel method to generate full-length recombinant SMN protein using a mammalian expression system, which can be used to explore the application of other CPPs to deliver SMN protein as a treatment for SMA.
Mismatch negativity tells you how much you automatically care for your lover’s love
Authors: Chai Hao , Chen Wanzhen , Xu You , Hu Jing , Xu Shaofang , Zhang Jinhua , Wang Wei 
Published: March 2014

AbstractUnderstanding the automatic process of love oriented to a participant by his or her own lover helps to build a normal loving relationship. It also helps to elucidate some of the underlying mechanisms of pathological love, which involves both repetitive and uncontrolled attention and care. Previous studies have addressed the late-stage process of love, but its early or automatic stage has been studied less. When processing a change in speech from “love” to “love you” from their own lover, participants showed a more prefrontal-frontal distribution of cerebral mismatch negativity. Source analysis showed that the left superior temporal gyrus was involved in all participants. The right inferior frontal gyrus was additionally involved in some participants who evaluated love as more intense. Brain areas activated in process might inversely indicate how much a participant cares about the love oriented by their lover.
The language of visual representations in the neurosciences — relating past and future
Authors: Stahnisch Frank 
Published: March 2014

AbstractIn theoretical accounts of the neurosciences, investigative research programs have often been separated into the morphological and physiological tradition. The morphological tradition is seen as describing the structure and form of the external and interior parts of the brain and spinal cord. The physiological tradition is interpreted as a compilation of those approaches which investigate cerebral functions particularly in their dynamic interactions. It must be regarded as an open question, though, whether the distinction between the morphological and physiological tradition in modern clinical and basic neuroscience has now become obsolete with the most recent neuroimaging techniques, such as fMRI, PET scans, SPECT, etc. Taken at face value, these new imaging techniques seem to relate, overlap, and even identify the anatomical with the functional substrate, when mapping individual patterns of neural activity across the visually delineated morphological structures. The particular focus of this review article is primarily on the morphological tradition, beginning with German neuroanatomist Samuel Thomas Soemmerring and leading to recent approaches in the neurohistological work of neuroscience centres in the United States and morphophysiological neuroimaging techniques in Canada. Following some landmark research steps in neuroanatomy detailed in the first section, this article analyzes the changing trajectories to an integrative theory of the brain in its second section. An examination of the relationship between form and function within the material culture of neuroscience in the third and final part, will further reveal an astonishingly heterogeneous investigative and conceptual terrain.
Relation between the type of wave exposure and seagrass losses (Cymodocea nodosa) in the south of Gran Canaria (Canary Islands — Spain)
Authors: Portillo Eduardo 
Published: March 2014

Abstract
Effects of different types of wave events on Cymodocea nodosa seagrass meadows were observed and investigated by quantitative and qualitative evaluation of material washed ashore a few days after the events. The studied seagrass meadows are located on the south coast of the island of Gran Canaria (Canary Islands — Spain) and they are protected from frequent swells arriving from the North Atlantic. However, sporadic phenomena associated with winter storms occasionally hit this coastline, causing the loss of entire plants (fresh leaves with rhizomes and roots attached). An unusual type of southern swells generated in the South Atlantic also reaches the Islands in spring and summer. A clear relation was observed between the wave events (southern swells and storm waves) and the material cast ashore over the following days, with differences in composition (fresh vs. decaying leaves) depending on the type of event. After southern swells, detached portions of C. nodosa consisted mostly of decaying leaves shed after senescence. These old swells cause frictional drag with moderate oscillations over a wider range at greater depths, removing only decaying leaves from the seagrass meadows and favoring the natural clean-up process.
The first report on Amphipoda from Marian Cove, King George Island, Antarctic
Authors: Kim Jee-Hoon , Jażdżewska Anna , Choi Han-Gu , Kim Won 
Published: March 2014

Abstract
This is a first account on amphipods from Marian Cove in Maxwell Bay, near the King Sejong Station, King George Island, the Antarctic. We have conducted a survey in 14 localities in the shallow sublittoral zone. A total of 22 amphipod species belonging to 12 families were identified. Six of these species were new for the whole Maxwell Bay. Our findings increase the amphipod fauna of Maxwell Bay from 55 to 61 species. The dominant species in the shallow sublittoral zone of Marian Cove were: Cheirimedon femoratus and Gondogeneia antarctica, followed by Bovallia gigantea, Orchomenella cf. ultima, Paradexamine fissicauda, Prostebbingia brevicornis, Pariphimedia integricauda, and Jassa wandeli.
Evaluation of cellular antioxidant activity of selected species of Caralluma and Boucerosia on cell lines
Authors: Vajha Madhuri , Chillara Siva Rama Krishna 
Published: March 2014

Objective: The aim of the present work was designed to study cellular antioxidant properties of selected plant extracts of Caralluma and Boucerosia on cell lines. Materials and Methods: The present study was carried out in four species of Caralluma R.Br. such as Caralluma adscendens (Roxb.) R. Brown var. attenuata (Wight) Grav. & Mayur. (CAA), Caralluma adscendens (Roxb.) R. Brown var. fimbriata (Wall.) Gravely & Mayur. (CAF), Caralluma stalagmifera C.E.C. Fisch. (CS) and Caralluma stalagmifera C.E.C. Fisch. var. longipetala Karupp. & Pull. (CSL) and as well as two species of Boucerosia Wight & Arn. such as Boucerosia lasiantha Wight. (BL) and Boucerosia umbellata (Haw.) Wight & Arn. (BU). The antioxidant efficacy was evaluated by ability of antioxidant molecules in the extract to scavenge ROS produced by normal metabolism by cells, observed by the oxidation of 2, 7- Dichloro fluorescein diacetate to dichlorofluorescein, followed by decrease in fluorescence intensity. Results: Cellular antioxidant activity was demonstrated by the inhibitory concentration 50% (IC50) of reactive oxygen species (ROS). The percentage ROS inhibition in Raw 264.7 cells when treated with different concentrations of methanolic extracts showed variations among selected species. Conclusion: The plant extracts were shown to be effective for antioxidant potential and can be a promising source of natural antioxidants.DOI: http://dx.doi.org/10.3126/ijasbt.v2i1.9649Int J Appl Sci Biotechnol, Vol. 2(1): 83-87
Quality of Vegetable Seeds Collected from Mymensingh Region in Bangladesh
Authors: Hossain I. , Dey P. , Dilruba K. 
Published: March 2014

Seed quality and health status of 11 vegetable crop seeds of viz. Cabbage (Brassica oleraceae var. capitata), Indian cabbage (Brassica oleraceae var. indica), Indian spinach (Basella alba), Spinach (Beta vulgaris var. bengalensis), Red amaranth (Amaranthus tricolor), Bitter gourd (Momordic acharantia), Bottle gourd (Lagenaria siceraria), Sweet gourd (Cucurbita moschata), Carrot (Daucuscarrota var. sativa), Radish (Raphanus sativus), and Turnip (Brassica rapa) collected from the greater Mymensingh region of Bangladesh were tested. The germination percentage of seeds of the collected samples ranged from 11 to 100. The highest germination was recorded in indian cabbage (100%) followed by carrot (92%) and radish (90%), while the lowest was recorded in indian spinach seeds (11%). Altogether 10 fungi were found associated with the seeds which were Alternaria spp., Aspergillus flavus, Aspergillus niger, Botrytis cinerea, Chaetomium funicola, Curvularia spp., Fusarium spp., Penicillium spp., Phoma spp. and Rhizopus spp.. The highest total seed-borne fungal infection was found in bottle gourd (155%) followed by sweet gourd (145%). The lowest infection was found in turnip seeds (6%). The maximum number of dead seeds was found in indian spinach (89%) and no dead seed was found in indian cabbage. Among the vegetables seed samples, seedling vigour ranged from 59 to 3083, where the highest seedling vigour was observed in sweet gourd (3083) and the lowest was in indian spinach (59). DOI: http://dx.doi.org/10.3126/ijasbt.v2i1.9926 Int J Appl Sci Biotechnol, Vol. 2(1): 103-108
1914-1918 et la redéfinition de la guerre
Authors: Strachan Hew 
Published: March 2014

La Première Guerre mondiale a contribué à redéfinir la notion de stratégie, lui donnant une dimension politique qu’elle n’avait pas auparavant. De nouvelles institutions ont été créées pour permettre aux civils et aux militaires d’échanger sur les grandes orientations stratégiques. Au-delà de la stratégie, la « guerre totale » de 1914-1918 a transformé l’idée même de guerre. La mémoire de ce conflit doit être perpétuée : sa valeur dissuasive pourrait nous prémunir d’une nouvelle montée des extrêmes.
Deuil des héros antiques
Authors: Bonnellier Roseline 
Published: March 2014

Le héros est à l’origine un « demi-dieu ». Lorsque les dieux antiques se retirent, il perd l’adresse divine à laquelle le reliait sa gloire « immortelle ». Le destin de l’homme, ce « héros », change catégoriquement. Il nous faut nous en retourner dans le « temps » qui est plus « proprement » le nôtre, sur terre. Mais le deuil des héros antiques est « infini ». Le « complexe » descend du « mythe » tragique d’Œdipe.
Evaluation of Organochlorine Pesticides and Sex Steroids in Lower Niagara River Lake Sturgeon
Authors: Jacobs Gregory R. , Gundersen Deke T. , Webb Molly A. H. , Gorsky Dimitry , Kohl Kristina , Lockwood Kelsey 
Published: March 2014

Abstract
As a long-lived, late-maturing species, lake sturgeon Acipenser fulvescens are vulnerable to the bioaccumulation of contaminants, which may impact reproductive physiology. The purpose of this study was to use a nondestructive method to investigate the relationship between endocrine-disrupting contaminants and sex steroids in lake sturgeon from the lower Niagara River. We screened blood plasma samples from lower Niagara River lake sturgeon (n  =  63) during April and May of 2012 for concentrations of 17 organochlorine (OC) contaminants that may affect endocrine function, as well as for abnormal levels of sex steroids testosterone (T) and 17β-estradiol (E2). We found detectable levels of two OC contaminants in the blood plasma of lake sturgeon, DDE (n  =  21) and γ-BHC (n  =  1). In both cases, plasma contaminant concentration was well below levels known to adversely affect sturgeon reproductive physiology. In addition, qualitative analysis of chromatographs from plasma extracts did not show the presence of other peaks that matched polychlorinated biphenyl standard peaks. Comparisons of plasma steroid levels with those of others from the literature gave no indication of endocrine disruption, though plasma T levels were notably high in the lower Niagara River population. We conclude that plasma OC levels are below threshold levels found in the scientific literature that would affect lake sturgeon reproductive physiology, and that it is unlikely that significant contaminant-mediated endocrine disruption is occurring in this population.
Engagement of SLAMF2/CD48 Prolongs the Time Frame of Effective T Cell Activation by Supporting Mature Dendritic Cell Survival
Authors: Kis-Toth Katalin , Tsokos George C. 
Published: March 2014

Abstract
Signaling lymphocyte activation molecule family (SLAMF)2/CD48 is a coactivator and adhesion molecule on cells with hematopoietic origin. It ligates mainly SLAMF4 on effector/memory CD8+ T cells and NK cells, suggesting a potential role during viral infection, with SLAMF2 acting as a ligand to activate SLAMF4-bearing cells. The ability of SLAMF2 to signal on its own after it is engaged and the functional consequences are largely unknown. We found that cytosolic DNA-activated dendritic cells (DCs) upregulate the expression of SLAMF2 molecules. Using anti-SLAMF2 Ab and SLAMF4 recombinant protein, we found that SLAMF2 engagement activates immature DCs and, more interestingly, prolongs the survival of DNA-activated DCs by inhibiting IFN-β production and IFN-β–induced apoptosis and promotes the production of the granzyme B inhibitor protease inhibitor-9. Thus, SLAMF2 can serve as a survival molecule for DNA-activated DCs during their interaction with SLAMF4-expressing cytotoxic T cells. Based on our results, we propose that SLAMF2 engagement regulates adaptive immune responses by providing longer access of putative APCs to virus-specific effector T cells by prolonging the time frame of effective stimulation.
Tobacco or Health?
Authors: Wang Long-de 
Published: March 2014

Abstract
It’s no doubt that smoking causes severe impair to health, and China is the world’s number one country in terms of cigarette consumption. Based on the global situation of tobacco control and the enforcement status of the World Health Organization Frame work Convention on Tobacco Control in China, this paper proposed some measures to promote the comprehensive tobacco control, such as legislation and specification of the responsibilities of all levels of government in this respect.
Advances of studies on blood diseases and bone marrow microvessel
Authors: Wu Di-jiong , Zhou Yu-hong , Ye Bao-dong , Yu Qing-hong 
Published: March 2014

Abstract
Bone marrow microvessel plays an important role in the onset and progression of hematologic diseases whose genesis is regulated by a variety of regulatory factors. Since abnormal angiogenesis has been found in a number of malignant and non-malignant hematologic diseases, microvessel density can be a valuable prognostic indicator, and also a stratifying factor in some of these diseases. In some cases, inhibiting or stimulating angiogenesis with certain treatments may be very important in improving therapeutic outcomes. However, mechanisms underlying these effects are yet to be further investigated.
High incidence of malnutrition in elective vascular surgery patients: An observational auditing study
Authors: De Waele Elisabeth , Moerman Leslie , Van Bael Kobe , Aerden Dimitri , Debing Erik , Honoré Patrick M. , Van den Brande Pierre 
Published: March 2014

Abstract
Background:Malnutrition has been shown to have an adverse effect on the clinical outcome of surgical patients. A >10% body weight loss in the previous 6 months is a significant preoperative predictor of worse post-operative outcome. There are limited data on malnutrition in vascular surgery patients. The current study was designed to investigate the prevalence of malnutrition in elective vascular surgery patients. Materials and Methods: This is a prospective, observational, auditing study carried out in department of vascular surgery of a tertiary, university and teaching hospital. All patients scheduled to undergo vascular surgery in a 4-month period were screened for malnutrition using the Nutritional Risk Score 2002. Nutritional status was assessed by body weight, body mass index, serum albumin and physical examination by a member of the hospitals’ nutrition team. The body weight was determined daily until 30 days post-operatively. Statistical analysis was performed using SPSS Statistics, Release Version 20.0.0. Results: On admission, 14 of 23 patients (61%) were at risk of malnutrition (Nutritional Risk Score 2002 ≥ 3). Assessment revealed no false-positive results. The mean post-operative body weight declined until Day 9. Afterwards, it rose with a mean weight gain of 1.32 kg. Conclusions: Malnutrition remains a largely unrecognized problem in vascular surgery patients. Given its detrimental effect, screening for malnutrition should be implemented in the pre-operative workup and therapeutic flow charts should be made available. Clear guidelines should also been made available for the bedside clinician.