bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of temperature and storage duration on measurement of activated partial thromboplastin time, D‐dimers, fibrinogen, prothrombin time and thrombin time, in citrate‐anticoagulated whole blood specimens
Authors: Zhao Y. , Lv G. 
Published: May 2013

SummaryIntroductionWe report the effect of temperature and storage duration on a range of haematological analytes: activated partial thromboplastin time (APTT), D‐dimers, fibrinogen (Fbg), prothrombin time (PT) and thrombin time (TT). All analytes were measured using a Sysmex CA7000 System with SIEMENS reagents.MethodsOne hundred and sixty patients were divided into two groups: samples from group A (80 patients) were used to assess the effect of storage at room temperature (RT) (0, 4, 8 and 24 h), and samples from group B (80 patients) were used to determine the effect of storage at 4 °C. Percentage changes compared with baseline results (T = 0 result) were calculated, and clinically relevant differences were defined as a percentage change of >10%.ResultsChanges in APTT, D‐dimer, Fbg, PT and TT results following 4, 8 and 24 h storage were statistically significant at RT and 4 °C. For D‐dimer, Fbg, PT and TT at both RT and 4 °C, the mean percentage changes after all storage periods were <10%, but for APTT, the mean percentage change following 24 h storage was >10% and exceeded the analytical within‐batch imprecision.ConclusionWe demonstrate that a storage time interval up to 24 h for D‐dimers, Fbg, PT, and TT, and 8 h for APTT at either RT or 4 °C is acceptable.
Quality and substance of educational strategies for mental health in undergraduate nursing curricula
Authors: Neville Christine , Goetz Sandra 
Published: May 2013

AbstractIn Australia, there is a workforce shortage of nurses in the mental health sector, and it is essential that universities play a part in the recruitment of nurses to work in this area. In this article, we present a literature review of educational strategies for mental health in undergraduate nursing curricula and how these align with the recommendations of the Mental Health Nurse Education Task Force. We reviewed quantitative and qualitative research from 2005 to 2012. Twelve studies from Australia and elsewhere of different types of educational courses and strategies were included for this review. The key topics identified were in relation to a general overview of programmes outlining the content and outcomes, clinical placement strategies, involvement of consumers and mental health nurses in curriculum delivery and oversight, e‐learning strategies, and implementation of mental health majors. Finally, limitations with considering the literature as a whole were highlighted, and recommendations made for future changes and research.
The Resources Boom and Economic Policy in the Long Run
Authors: Sheehan Peter , Gregory Robert G. 
Published: May 2013

AbstractAustralia's current resources boom has three elements: high terms of trade, strong investment and increased resource exports. For a decade, the net effect has been strongly positive: the boost to incomes and activity from the first two has more than offset the impact of the high Australian dollar. But, both resource investment and the terms of trade will fall in due course and the economy will face a major deflationary shock. A sustained policy response will be needed that recognises the limits of monetary policy and hence involves fiscal stimulus, together with innovative approaches to ensure that infrastructure investment rises rapidly.
A retrospective study of gender differences in depressive symptoms and risk of relapse in patients with alcohol dependence
Authors: Abulseoud Osama A. , Karpyak Victor M. , Schneekloth Terry , Hall‐Flavin Daniel K. , Loukianova Larissa L. , Geske Jennifer R. , Biernacka Joanna M. , Mrazek David A. , Frye Mark A. 
Published: May 2013

Background and ObjectivesThe aim of this study was to investigate potential gender differences in situations associated with heavy alcohol drinking.MethodsData from 395 alcohol dependent patients participating in the Mayo Clinic Intensive Addiction Program were evaluated. Each participant completed the inventory of drug taking situations (IDTS), Penn alcohol craving scale (PACS), patient health questionnaire (PHQ‐9), and/or Beck depression inventory (BDI). Gender differences in IDTS scores representing three domains (negative, positive, and temptation) of situations associated with heavy alcohol use were examined.ResultsWomen with alcohol dependence report a higher frequency of heavy drinking in unpleasant emotional (IDTS negative scores mean ± SD women vs. men: 52.3 ± 22.1 vs. 43.8 ± 21.8; p = .0006), and as a result of temptation (IDTS temptation scores mean ± SD women vs. men: 40.4 ± 23.0 vs. 35.3 ± 20.8; p = .035). Upon admission, women also scored significantly higher on depressive symptoms as measured by the BDI (23.4 ± 11.4 vs. 18.2 ± 9.8, p < .001). After controlling for depressive symptom severity as a covariate, the IDTS gender differences were no longer significant.Conclusion and Scientific SignificanceOur results suggest that unpleasant or temptation based emotional situations are a vulnerability risk factor for heavy drinking particularly in females. This risk appears to be at least partially driven by depressive symptom burden. Future research is needed to further investigate this finding. (Am J Addict 2013;22:437–442)
Leaf Cell‐Wall Components as Influenced in the First Phase of Salt Stress in Three Maize (Zea mays L.) Hybrids Differing in Salt Resistance
Authors: Uddin M. N. , Hanstein S. , Leubner R. , Schubert S. 
Published: May 2013

AbstractThe leaf cell wall (CW) chemical composition of three maize (Zea mays L.) hybrids (salt‐resistant SR 03 and SR 12, salt‐sensitive Pioneer 3906) was investigated in the first phase of salt stress (100 mm NaCl) compared with the control (1 mm NaCl) treatment to investigate whether changes in CW composition were responsible for shoot growth reduction. Salt treatment caused a strong inhibition in shoot growth with a concomitant increase in the ratio between CW dry mass (DM) and shoot fresh mass (FM) and a decrease in CW cellulose concentrations in all hybrids. NaCl caused a large increase in the concentrations of total and non‐methylated uronic acid (UA) in salt‐sensitive Pioneer 3906 and salt‐resistant SR 12. The onset of the accumulation of non‐methylated UA was delayed in SR 12, which indicates that this may be one reason for the better growth performance of this hybrid under salt stress compared with Pioneer 3906. It is concluded that a low accumulation of non‐methylated UA in leaf CW may, among other mechanisms, contribute to salt resistance in the first phase of salt stress.
Effects of soybean product intake on fasting and postload hyperglycemia and type 2 diabetes in Japanese men with high body mass index: The Saku Study
Authors: Tatsumi Yukako , Morimoto Akiko , Deura Kijyo , Mizuno Shoichi , Ohno Yuko , Watanabe Shaw 
Published: May 2013

AbstractAims/IntroductionThe inverse association between soybean intake and type 2 diabetes mellitus has been reported. We investigated the effects of soybean product intake on the incidence of type 2 diabetes mellitus considering fasting and postload hyperglycemia.Materials and MethodsThe present 4‐year, cohort study included 1,738 men and 1,301 women, aged 30–69 years, without diabetes mellitus at baseline who underwent comprehensive medical check‐ups between April 2006 and March 2007 at Saku Central Hospital. Participants were stratified by sex and body mass index (BMI), and further classified into three groups based on soybean product intake: group 1 (0–1 time/week), group 2 (2–3 times/week) and group 3 (four or more times per week). Participants underwent annual standard 75‐g oral glucose tolerance testing during follow‐up periods until March 2011. Main outcomes were incidence of fasting hyperglycemia, postload hyperglycemia and type 2 diabetes mellitus.ResultsDuring 10,503 person‐years of follow up, 204 participants developed type 2 diabetes mellitus, including 61 who developed fasting hyperglycemia and 147 who developed postload hyperglycemia. Among men with a high BMI, group 3 had significantly lower risk for the incidence of type 2 diabetes mellitus, fasting hyperglycemia and postload hyperglycemia than group 1, and multivariable‐adjusted hazard ratios and 95% confidence intervals were 0.44 (0.22–0.89), 0.36 (0.15–0.96) and 0.40 (0.18–0.92), respectively. Similar results were not observed among men with low BMI or women.ConclusionsSoybean product intake prevented fasting and postload hyperglycemia and type 2 diabetes mellitus in men with a high BMI. Further long‐term observation is necessary.
Evaluation of a 5‐year cervical cancer prevention project in Indonesia: Opportunities, issues, and challenges
Authors: Kim Young‐Mi , Lambe Fransisca Maria , Soetikno Djoko , Wysong Megan , Tergas Ana Isabel , Rajbhandari Presha , Ati Abigael , Lu Enriquito 
Published: May 2013

AbstractAimThe Cervical and Breast Cancer Prevention (CECAP) Project sought to develop a national model for cervical cancer prevention in Indonesia based on visual inspection with acetic acid (VIA) to detect abnormal changes in the cervix. The purpose of this study was to evaluate a pilot project introducing VIA and cryotherapy in Indonesia and to identify lessons learned that could be applied to the national scale‐up of cervical cancer prevention services.Material and MethodsFifty‐four months (July 2007 to December 2011) of service records at 17 health centers were abstracted and analyzed. The data were used to calculate the proportion of all women aged 30–50 who received VIA screening, the VIA‐positive rate, the treatment rate, and the interval between screening and treatment.ResultsThe 45 050 women screened during the project included 24.4% of the total female population in the target age group in the catchment area. Throughout the 5‐year project, 83.1% of VIA‐positive women sought cryotherapy. During the last 18 months of the project, after data collection tools were revised to more accurately reflect when cryotherapy was received, 13% of women were treated on the same day that they were screened. Among the 74% of women treated within 1 month of screening, the mean interval between screening and treatment was 7.2 days.ConclusionAs cervical cancer prevention services are scaled up throughout Indonesia, changes in the service delivery model and program management are needed to increase screening coverage, promote a single‐visit approach, and ensure the quality of services.
Late presentation of canine nasal tumours in aUKreferral hospital and treatment outcomes
Authors: Mason S. L. , Maddox T. W. , Lillis S. M. , Blackwood L. 
Published: May 2013

ObjectivesTo determine the computed tomographic stage of dogs with nasal tumours in aUKreferral population, and whether stage, time to referral and treatment correlates with outcome.MethodsRetrospective review of clinical records and computed tomography scans of dogs with nasal tumours.ResultsDogs (n=78) presented to a referral practice in theUKwith suspected nasal tumours are presented with more late stage tumours than dogs in theUSAand Japan. Length of time from initial presentation to referral did not correlate with tumour stage at diagnosis. Median survival times for radiotherapy‐treated dogs in this population are equivalent to those previously reported for late stage nasal tumours.Clinical SignificanceDogs with nasal tumours are presented late in the course of disease in the North West of England. Dogs with clinical signs consistent with a nasal tumour should have timely imaging and biopsy, in order to make prompt treatment decisions. Although survival times are comparable with previous reports and radiotherapy is a valid treatment option for dogs with late stage disease, better outcomes are likely to be achievable with earlier treatment.
Narrative Theory and the Sciences of Mind
Authors: Herman David 
Published: May 2013

AbstractStudies situated at the intersection between narrative theory and the sciences of mind share a common focus on mental capacities and dispositions that provide grounds for – or, conversely, are grounded in – narrative experiences. Two broad questions are therefore centrally relevant for this domain of inquiry: How do stories across media interlock with interpreters' mental capacities and dispositions, thus giving rise to narrative experiences? and How (to what extent, in what specific ways) does narrative scaffold efforts to make sense of experience itself? Analysts engaging with these questions have drawn on work in psychology, linguistics, the philosophy of mind, cognitive anthropology, and other fields as a source domain for concepts they seek to map onto the target domain of narrative studies. If research on narrative and mind is to become a bona fide interdiscipline, however, theorists need to move beyond one‐way borrowing and engage in genuine dialog and exchange, in part by establishing the relevance of traditions of narrative inquiry – the pertinence of ideas developed by scholars of story – for research on the scope and nature of intelligent activity. Using Ambrose Bierce's 1890 story “An Occurrence at Owl Creek Bridge” as an illustrative example, the present essay seeks to demonstrate how this kind of “transdisciplinary” approach to issues of narrative and mind can translate into practical strategies for engaging with specific stories. At the same time, the essay suggests that because the interrelations between narrative and mind cannot be exhaustively characterized by the arts and humanities, by the social sciences, or by the natural sciences taken alone, open, reciprocal exchanges across these fields of endeavor rather than unidirectional borrowing from a particular field that thereby becomes dominant are likely to promote the most productive interactions between narratology and the cognitive sciences.
Scholarship in Victorian Women and Medicine: An Overview
Authors: Swenson Kristine 
Published: May 2013

AbstractSince the mid‐1980s, scholars in the history of medicine, social history, women's studies, rhetoric, and literary/cultural studies have all recognized that women and medicine came together in particularly interesting ways in the nineteenth century. Between 1985 and 1990, feminists from across the disciplines drew upon a disparate array of more traditional scholarship to produce books that laid the groundwork for studies on Victorian women and medicine, books whose claims are still being tested and spun out in new scholarship. But although scholars in these various fields have borrowed liberally from one another's work, their critical assumptions and methodologies are often quite different. This essay provides an overview of the scholarship in Victorian women and medicine over the past several decades and suggests how the best recent work in the field attempts to achieve true interdisciplinarity.
Data Processing of Point Clouds for Object Detection for Structural Engineering Applications
Authors: Walsh Sara B. , Borello Daniel J. , Guldur Burcu , Hajjar Jerome F. 
Published: May 2013

AbstractThis research investigates the use of high‐resolution three‐dimensional terrestrial laser scanners as tools to capture geometric range data of complex scenes for structural engineering applications. Laser scanning technology is continuously improving, with commonly available scanners now able to capture over 1,000,000 points per second with an accuracy of ∼0.1 mm. This research focuses on developing the foundation toward the use of laser scanning to structural engineering applications, including structural health monitoring, collapse assessment, and post‐hazard response assessment. One of the keys to this work is to establish a process for extracting important information from raw laser‐scanned data sets such as the location, orientation, and size of objects in a scene, and location of damaged regions on a structure. A methodology for processing range data to identify objects in the scene is presented. Previous work in this area has created an initial foundation of basic data processing steps. Existing algorithms, including sharp feature detection and segmentation are implemented and extended in this work. Additional steps to remove extraneous and outlying points are added. Object detection based on a predefined library is developed allowing generic description of objects. The algorithms are demonstrated on synthetic scenes as well as validated on range data collected from an experimental test specimen and a collapsed bridge. The accuracy of the object detection is presented, demonstrating the applicability of the methodology. These additional steps and modifications to existing algorithms are presented to advance the performance of data processing on laser scan range data sets for future application in structural engineering applications such as robust determination of damage location and finite element modeling.
Inflammatory factors for hypoalbuminemia in Japanese peritoneal dialysis patients
Authors: Shioya Masuyo , Yoshida Takuya , Kasai Kenji , Furuya Ryuichi , Kato Akihiko , Mori Noriko , Matsumoto Yoshihiro , Kumagai Hiromichi 
Published: May 2013

Abstract:AimHypoalbuminaemia is a common complication of peritoneal dialysis (PD), and the leakage of albumin through peritoneal membrane may be a principal reason for hypoalbuminaemia. However, the relationship between peritoneal inflammation, peritoneal transport properties and hypoalbuminaemia has not been fully elucidated.MethodsA cross‐sectional study was performed on 76 Japanese PD patients who had been using a low‐glucose PD solution and icodextrin. Systemic inflammatory markers of C‐reactive protein (CRP) and serum interleukin‐6 (IL‐6), peritoneal effluent markers of dialysate IL‐6 and CA125, the dialysate‐to‐plasma ratio of creatinine (D/Pcr) and the dialysate protein concentration were measured and examined for their relationship with hypoalbuminaemia.ResultsThere was a significant positive correlation between serum IL‐6 and dialysate IL‐6, mean dialysate IL‐6 being significantly higher than mean serum IL‐6, suggesting that intraperitoneal inflammation was a principal origin of systemic inflammation. Both serum and dialysate IL‐6 were significantly correlated with serum albumin (r = −0.25, P < 0.05 and r = −0.32, P < 0.01, respectively). Dialysate IL‐6 was significantly correlated with D/Pcr and the dialysate protein concentration, and there was a significantly positive association between D/Pcr and the dialysate protein concentration. Dialysate CA125, which is argued to be a marker of mesothelial cell mass in this study, was positively correlated with D/Pcr and the dialysate protein concentration. The dialysate protein, dialysate IL‐6 and dialysate CA125 all increased according to the peritoneal transport rate defined by D/Pcr. A multiple‐regression analysis showed that serum albumin was independently associated with the age, D/Pcr and serum IL‐6.ConclusionHypoalbuminaemia was attributable to both the increased peritoneal permeability and systemic inflammation, and intraperitoneal inflammation might contribute to developing these complications.
A new anaplerotic respiratory pathway involving lysine biosynthesis in isocitrate dehydrogenase‐deficient Arabidopsis mutants
Authors: Boex‐Fontvieille Edouard R. A. , Gauthier Paul P. G. , Gilard Françoise , Hodges Michael , Tcherkez Guillaume G. B. 
Published: May 2013

Summary

The cornerstone of carbon (C) and nitrogen (N) metabolic interactions – respiration – is presently not well understood in plant cells: the source of the key intermediate 2‐oxoglutarate (2OG), to which reduced N is combined to yield glutamate and glutamine, remains somewhat unclear.

We took advantage of combined mutations of NAD‐ and NADP‐dependent isocitrate dehydrogenase activity and investigated the associated metabolic effects in Arabidopsis leaves (the major site of N assimilation in this genus), using metabolomics and 13C‐labelling techniques.

We show that a substantial reduction in leaf isocitrate dehydrogenase activity did not lead to changes in the respiration efflux rate but respiratory metabolism was reorchestrated: 2OG production was supplemented by a metabolic bypass involving both lysine synthesis and degradation.

Although the recycling of lysine has long been considered important in sustaining respiration, we show here that lysine neosynthesis itself participates in an alternative respiratory pathway. Lys metabolism thus contributes to explaining the metabolic flexibility of plant leaves and the effect (or the lack thereof) of respiratory mutations.
Geological and ecological factors drive cryptic speciation of yews in a biodiversity hotspot
Authors: Liu Jie , Möller Michael , Provan Jim , Gao Lian‐Ming , Poudel Ram Chandra , Li De‐Zhu 
Published: May 2013

Summary

The interplay of orographic uplift and climatic changes in the Himalaya‐Hengduan Mountains region (HHM) have had a key role in speciation and population demography. To gain further insight into these processes, we investigated their effects on Taxus wallichiana by combining molecular phylogeography and species distribution modeling.

Molecular data were obtained from 43 populations of T. wallichiana. Nineteen climatic variables were analyzed alongside genetic discontinuities. Species distribution modeling was carried out to predict potential past distribution ranges.

Two distinct lineages were identified, which diverged c. 4.2 (2.0–6.5) million years ago (Ma), a timescale that corresponds well with the recent uplift of the Qinghai‐Tibet Plateau and subsequent climatic changes of the region. Correlations with climatic variables also suggest that ecological factors may have further reinforced the separation of the two lineages. Both lineages experienced population expansion during the last glaciation.

The high genetic divergence, long‐term isolation and ecological differentiation suggest a scenario of cryptic speciation in T. wallichiana associated with geological and climatic changes in the HHM. Our findings also challenge the notion of general population ‘contraction’ during the last glaciation in the HHM.
Optimization of BY‐2 cell suspension culture medium for the production of a human antibody using a combination of fractional factorial designs and the response surface method
Authors: Vasilev Nikolay , Grömping Ulrike , Lipperts Anja , Raven Nicole , Fischer Rainer , Schillberg Stefan 
Published: May 2013

SummaryWe have developed a strategy for the optimization of plant cell suspension culture media using a combination of fractional factorial designs (FFDs) and response surface methodology (RSM). This sequential approach was applied to transformed tobacco BY‐2 cells secreting a human antibody (M12) into the culture medium, in an effort to maximize yields. We found that the nutrients KNO3, NH4NO3 and CaCl2 and the hormones 2,4‐dichlorophenoxyacetic acid (2,4–D) and 6‐benzylaminopurine (BAP) had the most significant impact on antibody accumulation. The factorial screening revealed strong interactions within the nutrients group (KNO3, NH4NO3 and CaCl2) and also individually between 2,4‐D and three other components (KNO3, NH4NO3 and BAP). The RSM design resulted in a fivefold increase in the antibody concentration after 5 days and a twofold reduction in the packed cell volume (PCV). Longer cultivation in the optimized medium led to the further accumulation of antibody M12 in the culture medium (up to 107 μg/mL, day 10). Because the packed cell volume was reduced in the optimized medium, this enhanced the overall yield by 20‐fold (day 7) and 31‐fold (day 10) compared to the conventional MS medium.