bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of psychopathy factors in reactive aggression within a sample of prisoners
Authors: Debowska Agata , Zeyrek Rios Emek Yuce 
Published: January 2015

Purpose
– The purpose of this paper is to examine the role of four psychopathy factors (Interpersonal Manipulation (IPM), Callous Affect (CA), Erratic Lifestyle (ELS), and Antisocial Behaviour (ASB)) and the length of incarceration in reactive aggression. The predictive effect of dissatisfaction with peer relations, childhood experiences of violence, and criminal friends on reactive forms of aggressive acts is also explored.

Design/methodology/approach
– In total, 129 (n=129) male prisoners incarcerated in Stargard Szczecinski Prison were recruited for the study. Cross-sectional design using self-report questionnaire of retrospective and prospective nature was utilised.

Findings
– Hierarchical multiple regression analysis revealed that only one psychopathy facet, IPM, forms a significant association with reactive aggression. Another accurate correlate of reactive aggression was the length of incarceration.

Originality/value
– The results of the present study indicate that the commonly suggested two-factor models of psychopathy may be misguided. Future studies examining the effect of psychopathy facets on aggression should consider IPM and CA as separate dimensions. Additionally, this study is the first to demonstrate that reactive aggression may be exacerbated during incarceration.
Innovation in clusters: exploration capacity, networking intensity and external resources
Authors: Expósito-Langa Manuel , Tomás-Miquel José-Vicente , Molina-Morales F. Xavier 
Published: January 2015

Purpose
– The purpose of this paper is to present an integrated model of the determinants of innovation in clusters. In the understanding, internal, external and relational dimensions must be considered to make up a complete picture of the innovation processes. The authors propose that the exploration capacity of the firm, as well as its networking intensity and the external resources provided by supporting organizations are relevant in this context.

Design/methodology/approach
– The empirical study has drawn on the population of the firms belonging to the Valencian textile industrial cluster in Spain and was carried out in two different phases. In the first step the authors applied the social network analysis technique to study the relational structure of the participating companies, followed by a second analysis aimed at performing a more detailed analysis of the companies that answered the roster by means of face-to-face interviews.

Findings
– Results suggest that firms in clusters must develop individual capacities parallel to the systemic resources in order to improve their innovation performance. These systemic resources are provided by the position in the knowledge network and the relations with Knowledge Intensive Business Services (KIBS), as agents that connect the cluster with external networks.

Originality/value
– In spite of diverse contributions, previous research only provides a partial explanation of the issue and others underestimate one of the elements (internal or external to the firm) where the sources of innovation are generated. The originality of this study lies in the fact that it presents a complete perspective of the innovation process in clustered firms and clarifies key questions in cluster studies through network analysis techniques.
Scalable decision support for digital preservation: an assessment
Authors: Becker Christoph , Faria Luis , Duretec Kresimir 
Published: January 2015

Purpose– This article aims to evaluate a new architecture for scalable decision-making and control in preservation environments for its ability to address five key goals: scalable content profiling; monitoring of compliance, risks and opportunities; efficient creation of trustworthy plans; context awareness; and loosely coupled preservation ecosystems. Scalable decision support and business intelligence capabilities are required to effectively secure content over time.Design/methodology/approach– We conduct a systematic evaluation of the contributions of the SCAPE Planning and Watch suite to provide effective and scalable decision support capabilities. We discuss the quantitative and qualitative evaluation of advancing the state of art and report on a case study with a national library.Findings– The system provides substantial capabilities for semi-automated, scalable decision-making and control of preservation functions in repositories. Well-defined interfaces allow a flexible integration with diverse institutional environments. The free and open nature of the tool suite further encourages global take-up in the repository communities.Research limitations/implications– The article discusses a number of bottlenecks and factors limiting the real-world scalability of preservation environments. This includes data-intensive processing of large volumes of information, automated quality assurance for preservation actions, and the element of human decision-making. We outline open issues and future work.Practical implications– The open nature of the software suite enables stewardship organizations to integrate the components with their own preservation environments and to contribute to the ongoing improvement of the systems.Originality/value– The paper reports on innovative research and development to provide preservation capabilities. The results of the assessment demonstrate how the system advances the control of digital preservation operations fromad hocdecision-making to proactive, continuous preservation management, through a context-aware planning and monitoring cycle integrated with operational systems.
Establishing of a Slovenian open access infrastructure: a technical point of view
Authors: Ojsteršek Milan , Brezovnik Janez , Kotar Mojca , Ferme Marko , Hrovat Goran , Bregant Albin , Borovič Mladen 
Published: January 2015

Purpose– The purpose of this paper is to present a technical perspective when implementing the Slovenian open access infrastructure that consists of four institutional repositories (IRs) and a national portal (NP) that aggregates content from the repositories in order to provide a common search engine, recommendations of similar documents, and similar text detection.Design/methodology/approach– During the project, the necessary legal background and processes for mandatory submissions of final study works, research publications and research data were established, as well as processes for data exchange between the IRs and the NP, and processes for similar text detection.Findings– The consortium consisted of four Slovenian universities that significantly differ in size, organisation, and workflows. It was anticipated that exactly the same legal background and software would be used for the four repositories. It turned out that complete unification was impossible due to the differences.Practical implications– The national open access infrastructure will improve the visibility of Slovenian research organisations. It supports the compliance with the funders’ open access mandates. The established infrastructure enables the depositing and archiving of approximately 80 percent of the peer-reviewed scientific publications that are annually published by Slovenian researchers. At the same time, the majority of final study works from Slovenian higher education institutions are available in full-text format.Originality/value– This paper describes a technical perspective for setting up a national open access infrastructure, which has not been described in the literature previously.
The D-NET software toolkit
Authors: Manghi Paolo , Artini Michele , Atzori Claudio , Bardi Alessia , Mannocci Andrea , La Bruzzo Sandro , Candela Leonardo , Castelli Donatella , Pagano Pasquale 
Published: January 2015

Purpose
– The purpose of this paper is to present the architectural principles and the services of the D-NET software toolkit. D-NET is a framework where designers and developers find the tools for constructing and operating aggregative infrastructures (systems for aggregating data sources with heterogeneous data models and technologies) in a cost-effective way. Designers and developers can select from a variety of D-NET data management services, can configure them to handle data according to given data models, and can construct autonomic workflows to obtain personalized aggregative infrastructures.

Design/methodology/approach
– The paper provides a definition of aggregative infrastructures, sketching architecture, and components, as inspired by real-case examples. It then describes the limits of current solutions, which find their lacks in the realization and maintenance costs of such complex software. Finally, it proposes D-NET as an optimal solution for designers and developers willing to realize aggregative infrastructures. The D-NET architecture and services are presented, drawing a parallel with the ones of aggregative infrastructures. Finally, real-cases of D-NET are presented, to show-case the statement above.

Findings
– The D-NET software toolkit is a general-purpose service-oriented framework where designers can construct customized, robust, scalable, autonomic aggregative infrastructures in a cost-effective way. D-NET is today adopted by several EC projects, national consortia and communities to create customized infrastructures under diverse application domains, and other organizations are enquiring for or are experimenting its adoption. Its customizability and extendibility make D-NET a suitable candidate for creating aggregative infrastructures mediating between different scientific domains and therefore supporting multi-disciplinary research.

Originality/value
– D-NET is the first general-purpose framework of this kind. Other solutions are available in the literature but focus on specific use-cases and therefore suffer from the limited re-use in different contexts. Due to its maturity, D-NET can also be used by third-party organizations, not necessarily involved in the software design and maintenance.
An investigation into the perceptions of academic librarians and students towards next-generation OPACs and their features
Authors: Osborne Hollie M. , Cox Andrew 
Published: January 2015

Purpose
– The purpose of this paper is to determine whether features of next-generation Online Public Access Catalogue (OPAC) interfaces are useful and intuitive to users who have different levels of searching ability. In addition, it investigates whether there is a difference between librarians’ and students’ preferences for specific features.

Design/methodology/approach
– The research is based on 18 semi-structured interviews conducted in July 2012 with three groups of library users from The University of Sheffield: librarians; Master of Arts Librarianship students; and a group of other post-graduate students.

Findings
– Overall, this study suggests that while the next-generation catalogue interfaces and features are useful, they are not as “intuitive” as some previous studies have claimed. Interviewees appeared to prefer the searching and browsing options over the Web 2.0 features. Both librarians and students have similar opinions regarding the usefulness of next-generation OPAC features, but preferences are complex.

Research limitations/implications
– The study is based on one institution, and the disciplinary background of the post-graduate students was limited.

Practical implications
– Promoting next generation OPACs and explaining their features to users is essential.

Originality/value
– The paper adds to the understanding of users’ preferences in relation to next-generation OPACs, locating the findings of the current findings firmly in the context of previous literature.
Enhancing the management of unstructured data in e-learning systems using MongoDB
Authors: Stevic Milorad Pantelija , Milosavljevic Branko , Perisic Branko Rade 
Published: January 2015

Purpose
– Current e-learning platforms are based on relational database management systems (RDBMS) and are well suited for handling structured data. However, it is expected from e-learning solutions to efficiently handle unstructured data as well. The purpose of this paper is to show an alternative to current solutions for unstructured data management.

Design/methodology/approach
– Current repository-based solution for file management was compared to MongoDB architecture according to their functionalities and characteristics. This included several categories: data integrity, hardware acquisition, processing files, availability, handling concurrent users, partition tolerance, disaster recovery, backup policies and scalability.

Findings
– This paper shows that it is possible to improve e-learning platform capabilities by implementing a hybrid database architecture that incorporates RDBMS for handling structured data and MongoDB database system for handling unstructured data.

Research limitations/implications
– The study shows an acceptable adoption of MongoDB inside a service-oriented architecture (SOA) for enhancing e-learning solutions.

Practical implications
– This research enables an efficient file handling not only for e-learning systems, but also for any system where file handling is needed.

Originality/value
– It is expected that future single/joint e-learning initiatives will need to manage huge amount of files and they will require effective file handling solution. The new architecture solution for file handling is offered in this paper: it is different from current solutions because it is less expensive, more efficient, more flexible and requires less administrative and development effort for building and maintaining.
Impact of cancer on the effectiveness of cardiac Troponin I to predict right ventricular dysfunction in acute pulmonary embolism
Authors: Keller Karsten , Geyer Martin , Beule Johannes , Coldewey Meike , Balzer Jörn Oliver , Dippold Wolfgang 
Published: January 2015

AbstractBackgroundDeep vein thrombosis (DVT) and pulmonary embolism (PE) are connected with a poor outcome in cancer patients. We aimed to investigate the impact of cancer on the effectiveness of cardiac Troponin I (cTnI) to predict right ventricular dysfunction (RVD) in acute PE.MethodsWe retrospectively analyzed the data of 182 patients with confirmed PE. PE patients were subdivided into two groups: (i) with concomitant active cancer disease or history of cancer, and (ii) without known cancer. Receiver operating characteristic (ROC) curves with area under the curve (AUC) was calculated for cTnI predicting RVD and related cut‐off levels for both groups.ResultsThirty‐seven PE patients (20.3%) had an active cancer disease or a history of cancer. In contrast, 145 (79.7%) of the included PE patients did not have a known cancer disease or a history of cancer.In the PE group with cancer, analysis of the ROC curve showed an AUC of 0.76 for cTnI predicting RVD with an optimal cut‐off value of 0.04 ng/mL; the risk of misclassification was 25.0%. In the PE group without cancer, AUC was 0.81 for cTnI predicting RVD with an optimal cut‐off value of 0.015 ng/mL; the risk of misclassification was 24.9%.ConclusionscTnI is effective for predicting RVD in PE patients with and without cancer. However, the effectiveness of cTnI to predict RVD was higher in PE patients without cancer than in those with cancer or a history of cancer.
Distribution and genetic diversity of Tomato spotted wilt virus following an incursion into Kenya
Authors: Macharia I. , Backhouse D. , Ateka E.M. , Wu S.‐B. , Harvey J. , Njahira M. , Skilton R.A. 
Published: January 2015

AbstractTomato spotted wilt virus (TSWV) affects the production of many horticultural crops worldwide. It was first reported from Kenya in 1999. The occurrence, distribution and genetic diversity of TSWV were evaluated in four tomato production areas in Kenya a decade after this incursion. The awareness of TSWV and its vectors among farmers was assessed through a questionnaire while plant samples including tomato leaves and fruit were collected from diseased and non‐diseased plants. The samples were assayed for TSWV using ELISA and reverse transcriptase‐polymerase chain reaction, and the resulting positive samples were sequenced. There was less awareness of the virus, its vectors and alternate hosts among farmers, despite the occurrence of the disease for over a decade. A total of 89 of 408 tomato samples tested positive for TSWV. Most of the positive samples came from Nakuru, where the virus was first detected, with only a single positive sample being obtained from Loitokitok and none from Bungoma or Kirinyaga. A phylogenetic analysis based on partial nucleocapsid (N) protein gene sequences suggested that the Kenyan isolates formed a single subgroup nested within a cluster of isolates that came predominantly from Europe. This indicated a single introduction that had undergone limited diversification. The study revealed that the disease has persisted in the area to which it was first introduced but has had very limited dispersal to other areas.
Intra‐individual reaction time variability based on ex‐Gaussian distribution as a potential endophenotype for attention‐deficit/hyperactivity disorder
Authors: Lin H.‐Y. , Hwang‐Gu S.‐L. , Gau S. S.‐F. 
Published: January 2015

ObjectiveIntra‐individual variability in reaction time (IIV‐RT), defined by standard deviation of RT (RTSD), is considered as an endophenotype for attention‐deficit/hyperactivity disorder (ADHD). Ex‐Gaussian distributions of RT, rather than RTSD, could better characterize moment‐to‐moment fluctuations in neuropsychological performance. However, data of response variability based on ex‐Gaussian parameters as an endophenotypic candidate for ADHD are lacking.MethodWe assessed 411 adolescents with clinically diagnosed ADHD based on the DSM‐IV‐TR criteria as probands, 138 unaffected siblings, and 138 healthy controls. The output parameters, mu, sigma, and tau, of an ex‐Gaussian RT distribution were derived from the Conners' continuous performance test. Multi‐level models controlling for sex, age, comorbidity, and use of methylphenidate were applied.ResultsCompared with unaffected siblings and controls, ADHD probands had elevated sigma value, omissions, commissions, and mean RT. Unaffected siblings formed an intermediate group in‐between probands and controls in terms of tau value and RTSD. There was no between‐group difference in mu value. Conforming to a context‐dependent nature, unaffected siblings still had an intermediate tau value in‐between probands and controls across different interstimulus intervals.ConclusionOur findings suggest IIV‐RT represented by tau may be a potential endophenotype for inquiry into genetic underpinnings of ADHD in the context of heterogeneity.
Pharmacogenetics of plasma efavirenz exposure in HIV‐infected adults and children in South Africa
Authors: Sinxadi Phumla Z. , Leger Paul D. , McIlleron Helen M. , Smith Peter J. , Dave Joel A. , Levitt Naomi S , Maartens Gary , Haas David W. 
Published: January 2015

AimsGenetic factors, notably CYP2B6 516G→T [rs3745274] and 983T→C [rs28399499], explain much of the interindividual variability in efavirenz pharmacokinetics, but data from Africa are limited. We characterized relationships between genetic polymorphisms and plasma efavirenz concentrations in HIV‐infected Black South African adults and children.MethodsSteady‐state mid‐dosing interval efavirenz concentrations were measured. We genotyped 241 polymorphisms in genes potentially relevant to efavirenz metabolism and transport, including ABCB1, CYP2A6, CYP2B6, CYP3A4, CYP3A5, NR1I2 and NR1I3.ResultsAmong 113 participants (59 adults and 54 children), minor allele frequencies for CYP2B6 516G→T, 983T→C, and 15582C→T [rs4803419] were 0.36, 0.07, and 0.09, respectively. Based on composite CYP2B6 15582/516/983 genotype, there were 33 extensive metabolizer, 62 intermediate metabolizer and 18 slow metabolizer genotypes. Median (IQR) mid‐dose efavirenz concentrations were 1.44 (1.21–1.93) µg ml–1, 2.08 (1.68–2.94) µg ml–1 and 7.26 (4.82–8.34) µg ml–1 for extensive, intermediate and slow metabolizers, respectively. In univariate analyses, a model that included composite genotype best predicted efavirenz concentrations (β = 0.28, 95% CI 0.21, 0.35, P = 2.4 × 10–11). Among individual CYP2B6 polymorphisms, 516G→T best predicted efavirenz concentrations (β = 0.22, 95% CI 0.13, 0.30, P = 1.27 × 10−6). There was also associations with 983T→C (β = 0.27, 95% CI 0.10, 0.44, P = 0.002) and 15582C→T (β = 0.11, 95% CI 0.01, 0.22, P = 0.04). Associations were consistent in adults and children. No other polymorphisms were independently associated with efavirenz concentrations.ConclusionsComposite CYP2B6 genotype based on CYP2B6 516G→T, 983T→C, and 15582C→T best described efavirenz exposure in HIV‐infected Black South African adults and children.
Fault‐controlled fluid flow inferred from hydrothermal vents imaged in 3D seismic reflection data, offshore NW Australia
Authors: Magee Craig , Duffy Oliver B. , Purnell Kirsty , Bell Rebecca E. , Jackson Christopher A.‐L. , Reeve Matthew T. 
Published: January 2015

AbstractFluid migration pathways in the subsurface are heavily influenced by pre‐existing faults. Although studies of active fluid‐escape structures can provide insights into the relationships between faults and fluid flow, they cannot fully constrain the geometry of and controls on the contemporaneous subsurface fluid flow pathways. We use 3D seismic reflection data from offshore NW Australia to map 121 ancient hydrothermal vents, likely related to magmatic activity, and a normal fault array considered to form fluid pathways. The buried vents consist of craters up to 264 m deep, which host a mound of disaggregated sedimentary material up to 518 m thick. There is a correlation between vent alignment and underlying fault traces. Seismic‐stratigraphic observations and fault kinematic analyses reveal that the vents were emplaced on an intra‐Tithonian seabed in response to the explosive release of fluids hosted within the fault array. We speculate that during the Late Jurassic the convex‐upwards morphology of the upper tip‐lines of individual faults acted to channelize ascending fluids and control where fluid expulsion and vent formation occurred. This contribution highlights the usefulness of 3D seismic reflection data to constraining normal fault‐controlled subsurface fluid flow.
Surgical Stress Induces Brain‐Derived Neurotrophic Factor Reduction and Postoperative Cognitive Dysfunction Via Glucocorticoid Receptor Phosphorylation in Aged Mice
Authors: Tian Xiao‐Sheng , Tong Ya‐Wei , Li Zheng‐Qian , Li Lun‐Xu , Zhang Tao , Ren Tian‐Yun , Zhou Ting , Wang He‐Cheng , Zhan Rui , Sun Yang , Yan Zhao , Wang Qiu‐Dian , Fan Dong‐Sheng , Kong Fan‐Jun , Guo Xiang‐Yang , Xiao Wei‐Zhong , Chui De‐Hua 
Published: January 2015

SummaryAimsThis study explored whether surgical stress‐induced glucocorticoid receptor (GR) phosphorylation is related to postoperative cognitive dysfunction (POCD) in aged individuals. Inhibition of GR activation could be an effective treatment for POCD.MethodsA laparotomy was given to C57/BL6 mice in POCD group both 20 and 6 months old. Animals in control group were treated in identical manners except for laparotomy. Cognitive function was evaluated by Morris water maze and elevated plus maze. Western blot and Elisa assay were used to detect related molecules. Mifepristone and roscovitine were treated as inhibitions of GR phosphorylation.ResultsThe cognitive function was impaired, and brain‐derived neurotrophic factor (BDNF) was found reduced in aged POCD group. GR translocation into nucleus and elevated GR phosphorylation were found in prefrontal cortex of aged POCD mice. Cyclin‐dependent Kinase 5 (CDK5), kinase for GR phosphorylation also elevated in aged POCD mice. With GR antagonist and CDK5 inhibitor, reduction of BDNF and cognitive dysfunction in aged mice were both rescued.ConclusionThese results presented a mechanism that surgical stress‐induced GR phosphorylation contributes to POCD in aged individuals. Inhibition of GR activation and phosphorylation might be a potential treatment target of POCD.