bluuebunny/crossref_metadata_2025_split huggingface dataset:
Digital death: the inheritance of digital information
Authors: Kanakova A. E. 
Published: June 2024

The subject of the research is the right to inherit digital information.The purpose of the research is to substantiate the need to conduct legal regulation of the consequences of the death of a person in the context of inheritance of digital data.The research is based on the analysis of sources of Russian and foreign law, as well as practical materials of Russian and foreign law in the sphere of rights and freedoms. The methodological basis of the research was formed by general scientific methods of cognition (analysis, synthesis, modelling) and private-scientific methods of cognition (comparativelegal, formal-logical).Main results. There are some approaches to the correlation of rights and freedoms realized in real and virtual space. The first approach considers digital or virtual rights and freedoms as a new legal phenomenon that requires separate legal regulation. The second approach assesses digital or virtual rights and freedoms as a manifestation of the features of those rights and freedoms that already exist outside the digital world. Although the first approach is more popular, the second approach is more correct because digital rights and freedoms either add a new territory of rights and freedoms or affect the mechanism of realization, but do not create a fundamentally new legal phenomenon.Because the death of a person does not automatically have consequences for the digital space, it is necessary to create a legal mechanism for recognising digital death, which will allow an individual who died in reality to become so for the virtual space. For the realisation of these powers it is not necessary to create completely new legal categories, it is enough to take into account the peculiarities of the realisation of offline rights and freedoms in virtual space.Conclusions. It seems more correct to move away from the concept of separating offline and online rights and to focus on the point-by-point introduction of digital rights and freedoms into existing legislation. Such an approach will not only ensure faster regulation of digital rights and freedoms, but will also make it possible to base legal regulation on provisions that have already had experience of implementation, and therefore identify possible gaps, problems, etc.
SYNTHESIS/SYNLETT Best Paper Awards 2023
Authors: Mukherjee Santanu , Sato Takaaki 
Published: June 2024

Thieme Chemistry and the editors of SYNTHESIS and SYNLETT present the "[SYNTHESIS/SYNLETT Best Paper Awards](https://www.thieme.de/de/thieme-chemistry/journals-synthesis-synlett-best-paper-awards-72162.htm)" to honor outstanding research in chemical synthesis. In this Thieme Cheminar, our speakers will present their research related to their award-winning articles which can be read [here](https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1941-8680) and [here](https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1912-3216).Our line-up:- Takaaki Sato (Japan) – “Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type Alkaloids”
- Santanu Mukherjee (India) – “Breaking Symmetry: Reaction Development Application to Complex Targets”Don't miss this opportunity to gain insights from leading scientists and learn about the latest advances in synthetic chemistry. RSVP above to save your spot!Breaking Symmetry: Reaction Development & Application to Complex TargetsHuman minds are fascinated by symmetrical objects, and we admire the challenges in constructing them. In contrast to the physical world, we live in, creating symmetry in the molecular world is a relatively simple task. It is the daunting asymmetry in molecules that often challenges the chemists. Breaking symmetry to generate asymmetry, known as desymmetrization, is a remarkably powerful strategy for building molecular complexity. Successful implementation holds the potential to forge multiple stereogenic centers, even away from the reaction site, in a single step. During the past few years, we have developed a number of organocatalytic enantioselective desymmetrization reactions, including a formal C-H alkylation. This talk will be primarily confined to the enantioselective formal C-H alkylation and its applications to the synthesis of complex targets.Total Synthesis and Anti-inflammatory Activity of Stemoamide-Type AlkaloidsThe stemoamide-type alkaloids have received considerable attention due to recent biological studies involving anti-inflammatory effects such as LPS-induced acute lung injury in mice. However, the structural complexity including pentacyclic scaffold prevents demonstration of the structural activity relationship. We achieve the collective total synthesis of the stemoamide-type alkaloids based on three key methods: 1) chemoselective assembly of five-membered rings, 2) stereodivergent construction of totally-substituted butenolides, and 3) direct oxidation of pyrrolidines. These methods enabled us to determine the systematic SAR, revealing that the pentacyclic framework including the totally substituted butenolide is crucial for anti-inflammatory activities.
Outcome Comparison between Carpometacarpal Arthroplasty and Trapeziectomy in Patients with Carpometacarpal Osteoarthritis: A Systematic review
Authors: Hidajat Nucki Nursjamsi , Aditya Rio , Arsa Widya , Malik Realita 
Published: June 2024

Background Osteoarthritis of the carpometacarpal (CMC) is considered a common musculoskeletal disorder. The treatment of carpometacarpal osteoarthritis could be either by conservative or surgical methods. surgical treatment, there are various alternatives, including trapeziectomy and arthroplasty. This study aims to perform a systematic review of the literature to determine the functional outcomes associated with trapeziectomy and arthroplasty in CMC arthritis. Objectives To determine the functional outcomes associated with trapeziectomy and arthroplasty in CMC arthritis patients. Methods A systematic review was conducted according to PRISMA guidelines and performed on August 2022 by one independent reviewer (author) using PubMed database, EBSCO Host, EMBASE, and ScienceDirect. The literature search will be based on Patients, Intervention, Control, and Outcome (PICO) criteria, as mentioned in the following: Patients with any carpometacarpal arthritis; with the intervention of using carpometacarpal arthroplasty as their method of surgery; control with trapeziectomy and primary outcome of functional outcome. Clinical outcomes using patient-reported outcome measures and complications were included. The quality of the included studies was evaluated with Cochrane risk-of-bias assessment tools. Quantitative analysis was performed by Review Manager 5.4. Results Three studies met the inclusion criteria for the systematic review. Both treatments resulted in significant improvements in functional scores. When matching patients according to preoperative function, patients receiving arthroplasty had better postoperative function (Quick DASH: trapeziectomy = 25.1, ARPE = 16.8). Conclusion This study showed that variable results of clinical outcomes improved after trapezeictomy and arthroplasty in patients with CMC arthritis. Evidence showed that arthroplasty allows for a better improvement in functional outcome.
Femorotibial angle on short knee radiographs fails to accurately predict the lower limb mechanical alignment. A systematic review and meta-analysis on different femorotibial angle definitions and short knee radiograph types
Authors: Giurazza Giancarlo , Perricone Giovanni , Franceschetti Edoardo , Campi Stefano , Gregori Pietro , Zampogna Biagio , Cardile Umberto Gabriele , Papalia Giuseppe Francesco , Papalia Rocco 
Published: June 2024

Introduction Hip-knee-ankle angle (HKA) on Full Limb Radiographs (FLRs) is the gold standard for coronal knee alignment assessment. Despite the widespread utilization of the more convenient femorotibial angle (FTA) on either antero-posterior (AP) or postero-anterior (PA) short knee radiographs (SKRs), its definition and correlation with HKA remains controversial. This review is the first to systematically investigate FTA-HKA correlation and the effect of different FTA methods and SKRs. Methods Systematic literature search (Pubmed, Scopus, Cochrane Library) followed PRISMA guidelines, to evaluate studies examining the FTA-HKA correlation. Meta-analyses compared the 3 most common FTA methods, knee center determination method and SKR types. Results 17 studies (2597 patients, 3234 knees) were included. The strongest correlation with HKA (r = 0.78) was found for FTA Method 1 (angle formed by lines drawn from the midpoint of tibial spines to points 10 cm above and below the joint line). No significant differences were observed when grouping the FTA methods by knee center assessment (Group I, r = 0.78; Group II, r = 0.77). AP SKRs showed a trend towards stronger FTA-HKA correlation compared to PA SKRs, in both Method 1 (r = 0.79 vs 0.75) and Method 3 (r = 0.80 vs 0.66). Conclusion Irrespective of its definition or type of SKR used, FTA lacks reliable accuracy in predicting the HKA in most knees. FLRs should be used whenever precise estimation of the patient’s alignment is necessary. Caution is warranted in interpreting studies investigating knee alignment or knee arthroplasty outcomes based on FTA.
Original method for evaluating the microcirculatory bed of the peripapillary optic nerve head in primary open-angle glaucoma
Authors: Fomin N. E. , Kuroyedov A. V. , Arkharov M. A. , Prokhorenko V. V. 
Published: June 2024

PURPOSE. To study the state of microcirculation in the peripapillary region of the optic nerve head (ONH) using an original method of objective assessment in the absence of the necessary licensed software.METHODS. A total of 30 patients (30 eyes) were included. The main group consisted of patients with early (subgroup 1, 10 eyes) and advanced (subgroup 2, 10 eyes) stages of primary open-angle glaucoma (POAG), the control group — individuals without history of ophthalmic complications (10 eyes). The peripapillary region of the ONH was examined using optical coherence tomography angiography (OCT-A). An original script was written in Python language for assessment of the prevalence of the vascular bed on the scans, analyzing an array of elements with brightness data.RESULTS. Subgroup 2 differed most from subgroup 1 in capillary deficiency in the superficial layer. Differences between the groups were found in the capillary network density in the superficial and deep vascular plexuses, in the superficial layer they were statistically significant (subgroup 1 — 27444.5±1372.2; subgroup 2 — 14126.5±706.3; control group — 45198.5±2259.9). Correlation analysis in advanced glaucoma confirmed almost complete atrophy of the superficial layer, which became almost "transparent" to the device.CONCLUSION. The developed method, based on the capabilities of OCT-A and additional machine analysis, can be used in the complex diagnostics of POAG both to confirm the stage of the pathological process and to assess the effectiveness of the ongoing therapeutic measures.
PERAN KELOMPOK TANI DALAM MENINGKATKAN PRODUKTIVITAS USAHA TANI PADI SAWAH DI DESA RANOIAPO
Authors: Kairupan Alin Juliana , Taroreh Johny , Rattu Febriyanti 
Published: June 2024

ABSTRAK
Penelitian ini bertujuan untuk mengetahui bagaimana peranan kelompok tani dalam peningkatan produktivitas usaha tani padi seta apa saja hambatan kelompok tani dalam peningkatan produktivitas usaha tani padi sawah di Desa Ranoiapo. Metode penelitian ini menggunakan metode kualitatif dengan instrument penelitian seperti wawancara, adapun yang menjadi objek dalam penelitian ini adalah Kelompok tani dan para Petani di Desa Ranoiapo. Hasil penelitian menunjukkan bahwa penting Peran kelompok tani di Desa Ranoiapo dapat tergambarkan dari produktivitas usaha tani yang meningkat, hadirnya kelompok tani juga dapat dijadikan sebagai mitra para petani untuk saling bertukar informasi dan belajar terkait pertanian, disisi lain terdapat beberapa hambatan yang dihadapi oleh kelompok tani seperti permasalahan pasokan pupuk dan benih yang sering terjadi yaitu kurangnya dan keterlambatan pasokan pupuk dan benih dari para mitra kelompok tani selain permasalaha pupuk dan benih modal juga menjadi masalah yang sering dihadapi oleh para petani.
Kata Kunci: Peranan, Kelompok Tani, Produktivitas Usaha Tani.

ABSTRACT
This research aims to find out the role of farmer groups in increasing the productivity of rice farming and what obstacles farmer groups have in increasing the productivity of rice farming in Ranoiapo Village. This research method uses qualitative methods with research instruments such as interviews. The objects of this research are farmer groups and farmers in Ranoiapo Village. The results of the research show that the important role of farmer groups in Ranoiapo Village can be illustrated by the increased productivity of farming businesses, the presence of farmer groups can also be used as partners for farmers to exchange information and learn related to agriculture, on the other hand there are several obstacles faced by farmer groups such as Fertilizer and seed supply problems that often occur, namely the lack and delay in the supply of fertilizer and seeds from farmer group partners, apart from capital fertilizer and seed problems, are also problems often faced by farmers.
Keywords: Roles, Farmer Groups, Farming Business Productivity
PENGARUH KOMPETENSI MENGAJAR GURU DAN MOTIVASI BELAJAR TERHADAP KEMAMPUAN BELAJAR SISWA SMA NEGERI 1 MODOINDING
Authors: Tamboto Henry 
Published: June 2024

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh kompetensi guru dan motivasi belajar siswa terhadap kemampuan belajar siswa SMA Negeri 1 Modoinding. Sampel dalam penelitian berjumlah 49 siswa. Hasil analisis data menunjukkan bahwa berdasarkan hasil komputasi data dietmui bahwa koefisien korelasi berada diatas sebesar 0,220. Dalam menentukan koefisien determinan dilakukan untuk menentukan besar kontribusi Kompetensi guru dan motivasi belajar siswa terhadap Kemampuan belajar siswa dengan menggunakan rumus KD = r2 x 100% = 0,220 x 100% = 22,0 % dengan demikian besar kontribusi kompetensi guru dan motivasi belajar siswa terhadap kemampuan belajar siswa adalah 22,0%. Berdasarkan hasil uji diatas, dapat dilihat f hitung sebesar 6,701 > f tabel sebesar 3,200 dengan demikian Kompetensi guru dan motivasi belajar siswa terhadap Kemampuan belajar siswa secara simultan berpengaruh terhadap Kemampuan belajar siswa.
Kata Kunci : Kompetensi Mengajar guru, Motivasi Belajar, Kemampuan Belajar Siswa
Janus Kinases and Autoimmunity: Bridging Pathways to Therapy
Authors: Wei Yazi , Zhang Tiantai 
Published: June 2024

Review
Janus Kinases and Autoimmunity: Bridging Pathways to Therapy

Yazi Wei 1, and Tiantai Zhang 1,*

State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 100050, China
* Correspondence: ttzhang@imm.ac.cn

Received: 7 February 2024; Revised: 1 March 2024; Accepted: 1 March 2024; Published: 5 June 2024

Abstract: Janus kinase (JAK) is a family of intracellular non-receptor tyrosine kinases with four members (JAK1, JAK2, JAK3, and Tyk2). The JAK-STAT (signal transducer and activator of transcription) pathway is an evolutionary conserved mechanism of transmembrane signal transduction relaying over 50 cytokines signals to regulate the proliferation, immune response, inflammation, and malignancy. The dysfunction of JAK-STAT signaling pathway is directly associated with the pathogenesis of inflammatory and autoimmune disorders, as well as tumor progression. Studies have shown that targeting the JAK family with small-molecule inhibitors can treat inflammatory and autoimmune diseases and myeloproliferative neoplasms. In this review, we discuss the current understanding of the JAK-STAT signaling and approved JAK inhibitors.
Integrins as Drug Targets in Vascular and Related Diseases
Authors: Meredith Emily , A. Schwartz Martin 
Published: June 2024

Review
Integrins as Drug Targets in Vascular and Related Diseases

Emily Meredith 1,*, and Martin A. Schwartz 1,2,3
1 Yale Cardiovascular Research Center, Department of Internal Medicine (Cardiology), Yale University School of Medicine, New Haven, CT 06511, USA, martin.schwartz@yale.edu
2 Department of Cell Biology, Yale School of Medicine, New Haven, CT 06520, USA.
3 Department of Biomedical Engineering, Yale University, New Haven, CT 06511, USA.
* Correspondence: Emily.meredith@yale.edu

Received: 6 April 2024; Revised: 28 May 2024; Accepted: 29 May 2024; Published: 21 June 2024

Abstract: Integrins are transmembrane receptors that, as critical participants in a vast range of pathological processes, are potential therapeutic targets. However, in only a few cases has the promise been realized by drug approval. In this review, we briefly review basic integrin biology and participation in disease, challenges in the development of safe, effective integrin-targeted therapies, and recent advances that may lead to progress.
UNet and Variants for Medical Image Segmentation
Authors: Ehab Walid , Huang Lina , Li Yongmin 
Published: June 2024

Article
UNet and Variants for Medical Image Segmentation

Walid Ehab, Lina Huang, and Yongmin Li *

Department of Computer Science, Brunel University London, Uxbridge, UB8 3PH, United Kingdom
* Correspondence: yongmin.li@brunel.ac.uk

Received: 22 September 2023
Accepted: 25 December 2023
Published: 26 June 2024

Abstract: Medical imaging plays a crucial role in modern healthcare by providing non-invasive visualisation of internal structures and abnormalities, enabling early disease detection, accurate diagnosis, and treatment planning. This study aims to explore the application of deep learning models, particularly focusing on the UNet architecture and its variants, in medical image segmentation. We seek to evaluate the performance of these models across various challenging medical image segmentation tasks, addressing issues such as image normalization, resizing, architecture choices, loss function design, and hyperparameter tuning. The findings reveal that the standard UNet, when extended with a deep network layer, is a proficient medical image segmentation model, while the Res-UNet and Attention Res-UNet architectures demonstrate smoother convergence and superior performance, particularly when handling fine image details. The study also addresses the challenge of high class imbalance through careful preprocessing and loss function definitions. We anticipate that the results of this study will provide useful insights for researchers seeking to apply these models to new medical imaging problems and offer guidance and best practices for their implementation.
Time Perspective-Enhanced Suicidal Ideation Detection Using Multi-Task Learning
Authors: Yang Qianyi , Zhou Jing , Wei Zheng 
Published: June 2024

Article
Time Perspective-Enhanced Suicidal Ideation Detection Using Multi-Task Learning

Qianyi Yang 1, Jing Zhou 1,*, and Zheng Wei 2

1 School of Computer and Cyber Sciences, Communication University of China, Beijing 100024, China
2 Zhongxing Telecommunication Equipment Corporation, Shenzhen 518057, China
* Correspondence: zhoujing@cuc.edu.cn

Received: 25 October 2023
Accepted: 5 March 2024
Published: 26 June 2024

Abstract: Suicide notes are written documents left behind by suicide victims, either on paper or on social media, and can help us understand the mentality and thought processes of those struggling with suicidal thoughts. In our preliminary work, we have proposed the use of Time Perspective (TP), which takes into consideration how people think of or appraise their past, present, or future life would shape their behavior, in suicide tendency detection based on suicide notes. The detection result is highly dependent upon a ternary classification task that groups any suicide tendency into one of the three pre-defined types. In this work, we define the suicidal emotion trajectory, a concept that is based on TP and used for depicting the dynamic evolution of an individual's emotional state over time, and this trajectory serve as an auxiliary task to the primary ternary classification task for a multi-task learning model, i.e. TP-MultiBert. The model features Bidirectional Encoder Representation from Transformer (BERT) components, replacing its counterpart, i.e., GloVe, in the previous model. Thanks to its desirable capability of understanding word contextual relationships, as well as multi-task learning capability of leveraging complementary information from various tasks, BERT shows promissing results in further improving the performance of suicide ideation detection.
“A Meditation Among Drums”: A Black Archive of Wandering at the Milford Graves: Fundamental Frequency Exhibit
Authors: Alonge Kehinde 
Published: June 2024

Abstract
This article follows my firsthand encounter with the Ars Nova Workshop and Artist Space's collaborative exhibit, Milford Graves: Fundamental Frequency, to fully engage with the question of how one might construct, or perhaps, more appropriately, deconstruct, an archive away from its typical neoliberal function to allow the propagation of “Black wandering” (explicitly thinking with and through Sarah Cervenak's use of the term “wandering”), whereby unrelenting subjectivity and disjunctive practices in temporality persist. As I navigated the visual and aural rubbings produced by the trove of Graves's life's ephemera, audio recordings, interviews with Marvin X, and heart monitor research, it remains clear that both his life and his music's experiential qualities, steeped in disorientation and dispersal, exceed the hold of the mediums that contain them, as they still exude a capacity in their arranged juxtapositions to produce what Baraka calls free jazz's “new thing.” Therefore, this article contends Graves's archive maintains a space by which, even in his passing, his sound and being can “reemerge as a new thing,” thus offering him futurity not predicated upon a corrected closure in the gap between the past and present but rather one forged by the disjunctive synthesis of moments that encourages those wandering amid its sonorous space to improvise their listening practices alongside Graves's unceasing improvisation, in indeterminate directions.
Gedragsnormen en rechtsvorming in het ondernemingsrecht
Authors: Kemp B. 
Published: June 2024

Gedragsnormen en rechtsvorming in het ondernemingsrecht
In zijn oratie gaat Kemp in op de verhouding tussen belangenpluralisme en rechtsvorming. Gezien de belangrijke rol van de rechter, en in het bijzonder de Ondernemingskamer, bij de rechtsvorming, wordt betoogd de toegang tot het enquêterecht te verbreden. Daar zou wel een aantal waarborgen tegenover moeten staan.