bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of soil tillage system on the nitrogen uptake, grain yield and nitrogen use efficiency of spring barley in a cool Atlantic climate
Authors: BRENNAN J. , FORRISTAL P. D. , McCABE T. , HACKETT R. 
Published: July 2014

SUMMARYField experiments were conducted between 2009 and 2011 in Ireland to compare the effects of soil tillage systems on the grain yield, nitrogen use efficiency (NUE) and nitrogen (N) uptake patterns of spring barley (Hordeum vulgare) in a cool Atlantic climate. The four tillage treatments comprised conventional tillage in spring (CT), reduced tillage in autumn (RT A), reduced tillage in spring (RT S) and reduced tillage in autumn and spring (RT A+S). Each tillage system was evaluated with five levels of fertilizer N (0, 75, 105, 135 and 165 kg N/ha). Grain yield varied between years but CT had a significantly higher mean yield over the three years than the RT systems. There was no significant difference between the three RT systems. Tillage system had no significant effect on the grain yield response to fertilizer N. As a result of the higher yields achieved, the CT system had a higher NUE than the RT systems at all N rates. There was no significant difference in NUE between the three RT systems. Conventional tillage had significantly higher nitrogen uptake efficiency (NUpE) than RT A and a significantly higher nitrogen utilization efficiency (NUtE) than all three RT systems. Crop N uptake followed a similar pattern each year. Large amounts of N were accumulated during the vegetative growth stages while N was lost after anthesis. Increased N rates had a positive effect on N uptake in the early growth stages but tended to promote N loss later in the season. The CT system had the highest N uptake in the initial growth stages but its rate of uptake diminished at a faster rate than the RT systems as the season progressed. Tillage system had an inconsistent effect on crop N content during the later growth stages. On the basis of these results it is concluded that the use of non-inversion tillage systems for spring barley establishment in a cool oceanic climate remains challenging and in certain conditions may result in a reduction in NUE and lower and more variable grain yields than conventional plough-based systems.
Cognitive behavioural therapy for anxiety disorders and insomnia: a commentary on future directions
Authors: Aho Kristin M. , Pickett Scott M. , Hamill Timothy S. 
Published: July 2014

AbstractAnxiety disorders and insomnia significantly impair daily functioning. Similar underlying mechanisms may account for the high comorbidity of both disorders, and respective treatments share pharmacological and behavioural features. This review suggests the utility of an integrated CBT approach in the treatment of generalized anxiety, post-traumatic stress, and panic disorders, and comorbid insomnia. Other anxiety disorders were not explored because current data are limited or inconsistent. A comprehensive, non-systematic review of the literature was conducted to evaluate the treatment of comorbid anxiety and insomnia disorders, and data reveal shared pharmacological and behavioural features of insomnia and anxiety disorders treatment. However, research demonstrates that CBT maintains successful treatment results longer than drug therapies. Despite similar treatment approaches, there is a paucity of research that explores integrated CBT approaches for comorbid anxiety and insomnia disorders. This review suggests that future research should assess the impact of combined therapeutic approaches on the simultaneous reduction of anxiety disorders, insomnia, and relapse rates.
Effects of ingesting highly branched cyclic dextrin during endurance exercise on rating of perceived exertion and blood components associated with energy metabolism
Authors: Furuyashiki Takashi , Tanimoto Hidenori , Yokoyama Yasuhiro , Kitaura Yasuyuki , Kuriki Takashi , Shimomura Yoshiharu 
Published: July 2014

Abstract
We compared the effect of relatively low doses (15 g) of highly branched cyclic dextrin (HBCD) with that of maltodextrin during endurance exercise on the rating of perceived exertion (RPE) in a crossover, double-blind study of healthy volunteers. The RPE increased during exercise and its increase was significantly less at 30 and 60 min after ingesting HBCD than maltodextrin.
Network-based analysis of genotype–phenotype correlations between different inheritance modes
Authors: Hao Dapeng , Li Chuanxing , Zhang Shaojun , Lu Jianping , Jiang Yongshuai , Wang Shiyuan , Zhou Meng 
Published: July 2014

Abstract
Motivation: Recent studies on human disease have revealed that aberrant interaction between proteins probably underlies a substantial number of human genetic diseases. This suggests a need to investigate disease inheritance mode using interaction, and based on which to refresh our conceptual understanding of a series of properties regarding inheritance mode of human disease.
Results: We observed a strong correlation between the number of protein interactions and the likelihood of a gene causing any dominant diseases or multiple dominant diseases, whereas no correlation was observed between protein interaction and the likelihood of a gene causing recessive diseases. We found that dominant diseases are more likely to be associated with disruption of important interactions. These suggest inheritance mode should be understood using protein interaction. We therefore reviewed the previous studies and refined an interaction model of inheritance mode, and then confirmed that this model is largely reasonable using new evidences. With these findings, we found that the inheritance mode of human genetic diseases can be predicted using protein interaction. By integrating the systems biology perspectives with the classical disease genetics paradigm, our study provides some new insights into genotype–phenotype correlations.
Contact: haodapeng@ems.hrbmu.edu.cn or biofomeng@hotmail.com
Supplementary information: Supplementary data are available at Bioinformatics online.
Repair of O6-methylguanine adducts in human telomeric G-quadruplex DNA by O6-alkylguanine-DNA alkyltransferase
Authors: Hellman Lance M. , Spear Tyler J. , Koontz Colton J. , Melikishvili Manana , Fried Michael G. 
Published: July 2014

Abstract
O 6-alkylguanine-DNA alkyltransferase (AGT) is a single-cycle DNA repair enzyme that removes pro-mutagenic O6-alkylguanine adducts from DNA. Its functions with short single-stranded and duplex substrates have been characterized, but its ability to act on other DNA structures remains poorly understood. Here, we examine the functions of this enzyme on O6-methylguanine (6mG) adducts in the four-stranded structure of the human telomeric G-quadruplex. On a folded 22-nt G-quadruplex substrate, binding saturated at 2 AGT:DNA, significantly less than the ∼5 AGT:DNA found with linear single-stranded DNAs of similar length, and less than the value found with the telomere sequence under conditions that inhibit quadruplex formation (4 AGT:DNA). Despite these differences, AGT repaired 6mG adducts located within folded G-quadruplexes, at rates that were comparable to those found for a duplex DNA substrate under analogous conditions. Repair was kinetically biphasic with the amplitudes of rapid and slow phases dependent on the position of the adduct within the G-quadruplex: in general, adducts located in the top or bottom tetrads of a quadruplex stack exhibited more rapid-phase repair than did adducts located in the inner tetrad. This distinction may reflect differences in the conformational dynamics of 6mG residues in G-quadruplex DNAs.
Development of an integrated model for RFID extension
Authors: Alamgir Hossain Mohammad 
Published: July 2014

Purpose
– In the literature, a number of models have been developed that explain the adoption behavior of a technological innovation. Similarly, most research explaining the continuance behavior of an information system (IS) ignores the adoption processes. It is observed that researchers seem uninterested in explaining the extension of an IS. The purpose of this paper is to develop an integrated model that explains the adoption, continuance, and extension of a technological innovation – taking radio frequency identification (RFID) as the case.

Design/methodology/approach
– Motivated by the exploratory nature of the current research, a qualitative field-study approach is adopted.

Findings
– Technology-organization-environment (TOE) factors influence RFID adoption while continuance is dependent on confirmation from the initial adoption. Finally, the extension decision is influenced by the TOE factors, self-efficacy, and situational factors.

Research limitations/implications
– The research was conducted in eight livestock farms in Western Australia and hence the factors explored can be location specific. This is the first methodological initiative explaining the extension behavior of a technological innovation.

Practical implications
– IS researchers may gain insight toward understanding the diffusion of innovation in the agricultural sector while agricultural agencies and farms can use the findings for their extension plan.

Originality/value
– This study is a single initiative developing an integrated model that explains the adoption diffusion of a technological innovation.
Financial malpractices and stock market development in Nigeria
Authors: Thompson Ojo Ade , Felix Ayadi Olusegun 
Published: July 2014

Purpose– The purpose of this paper is to investigate if the prevalence of corruption and other unwholesome financial practices in Nigeria contributed substantially to the stunted growth of the capital market in general, and the stock market in particular.Design/methodology/approach– The paper employed Gregory–Hansen cointegration approach to test the long-run equilibrium relationship between the occurrence of predatory banking practices and stock market capitalization in Nigeria.Findings– There exists a long-run equilibrium relationship between bank fraud and stock market capitalization but with a structural break in 2005.Practical implications– There is an urgent need to overhaul and re-assess from time to time the existing systems of internal checks and controls in banks, as well as other financial institutions in Nigeria.Originality/value– This paper is the first to empirically test the long-run equilibrium relationship between bank fraud and stock market capitalization in Nigeria.
Price presentation effects on green purchase intentions
Authors: Lee Weisstein Fei , Asgari Mohammadreza , Siew Shir-Way 
Published: July 2014

Purpose
– This paper aims to examine the effect of price promotion presentation formats on consumers’ green purchase intentions across various levels of greenness. Despite the increasing awareness of environmental issues and green products among consumers, there is a gap between their green attitude and purchase intentions. Previous studies show that consumers’ degree of greenness varies and that price plays an important role in their green consumption decision-making.

Design/methodology/approach
– Two between-subject experiments with 236 participants were used to examine our hypotheses and conceptual model.

Findings
– The results show that different formats of price promotion presentations influence consumers’ purchase perceptions differently. Consumers with a high degree of greenness are attracted to promotions emphasizing gain, while those with a low degree of greenness prefer promotions underlining reduced loss. In addition, medium-greenness consumers show similar reactions to both formats. Our studies further demonstrate that consumers’ perceived value mediates the moderated effects of perceived quality and perceived savings on green purchase intentions.

Practical implications
– This research helps marketers better design price promotions, taking into account the various levels of consumers’ greenness. The focus of reduced loss or gain of the promotional programs should be targeted at consumers with different levels of greenness.

Originality/value
– This is the first paper to examine the role of price promotion presentation formats in consumer decision-making regarding green consumption. The study provides new insights concerning how to design price promotions to enhance the green purchase intentions of consumers.
Educating professionals
Authors: Lubbe Ilse 
Published: July 2014

Purpose
– The purpose of this study is to describe the multiplicity of the role of the Accounting academic as a knowledge agent: in terms of the discovery of new knowledge and its recontextualisation into pedagogy, as well as effective teaching and learning in the field of Accounting.

Design/methodology/approach
– Through a literature review and the collection of qualitative data (using purposive sampling), this study describes the Accounting academic’s role as a knowledge agent, as viewed by Accounting academics and professional accountants, with the aim of providing insight into the tensions that exist in the education of professionals.

Findings
– The data collected in this study indicate that Accounting academics find themselves torn between their different roles: those of researcher and teacher. Accounting academics do not feel valued in their role as teachers, as at the university, more emphasis is placed and promotion is based on research, yet the Accounting profession places more value on their teaching and scholarship role.

Practical implications
– There is an urgent need in professional Accounting education (trapped within a multiple principal paradigm) for some fundamental re-thinking of the focal point of research, and the knowledge agency of academe, particularly within a developing economy, such as South Africa.

Originality/value
– The value of this paper is in its identification and description of the tensions experienced in the education of professional accountants. The university and profession are urged to value, acknowledge and reward the multiple roles of Accounting academics.
Police students’ social background, attitudes and career plans
Authors: Bringsrud Fekjær Silje 
Published: July 2014

Purpose– The purpose of this paper is to compare the social background of Norwegian and Swedish police students. Are there differences in the students’ social background, and if so, are such differences reflected in different attitudes and career plans among the students?Design/methodology/approach– The questions are explored on the basis of survey data on all Norwegian and Swedish police students who started their education in 2009 (n=737). The methods employed are cross-tabular analysis and multivariate linear regression.Findings– The results show that a larger proportion of Norwegian police students have highly educated parents, compared to the Swedish. However, students’ social background does not seem to be important for their orientation towards theory and knowledge or their plans for doing operational police work.Practical implications– An important question for the future's police educators is whether a study with a formal bachelor status will attract a different type of students. These results show that the Norwegian police education with a formal bachelor degree attracts more students with highly educated parents, but the importance of attracting students with a given social background to the police profession seems to be limited.Originality/value– There are no previous comparative studies on recruitment to police education, or studies of police recruitment that focus especially on the importance of social background.
Increased intravitreal adenosine 5′‐triphosphate, adenosine 5′‐diphosphate and adenosine 5′‐monophosphate levels in patients with proliferative diabetic retinopathy
Authors: Loukovaara Sirpa , Sahanne Sari , Jalkanen Sirpa , Yegutkin Gennady G. 
Published: July 2014

AbstractPurposeExtracellular purines play important role in ocular physiology, diabetes, vascular remodelling and adaptation to inflammation. This study was aimed to evaluate intravitreal purine levels in patients with diabetic retinopathy (DR) and other non‐vascular vitreoretinal eye diseases.MethodsVitreous samples were collected at the start of the three‐port pars plana vitrectomy. Study group comprised 55 eyes operated due to sight‐threatening forms of DR, including eyes of 24 patients with proliferative DR. Of the 143 non‐diabetic controls, 112 had rhegmatogenous retinal detachment and 31 macular hole or pucker. Intravitreal purine concentrations were determined using a combination of bioluminescent [adenosine 5′‐triphosphate (ATP), adenosine 5′‐diphosphate (ADP)] and fluorometric [adenosine 5′‐monophosphate (AMP), adenosine, inosine] enzyme‐coupled sensing assays.ResultsCompared with non‐diabetic controls, DR eyes contained significantly higher (p < 0.01) concentrations of ATP (4.2 ± 0.6 versus 34.5 ± 13.7 nm; mean ± SEM), ADP (19.5 ± 2.7 versus 43.7 ± 14.5 nm) and AMP (1290 ± 115 versus 1876 ± 190 nm). Intravitreal adenosine and inosine levels varied within submicromolar to low micromolar range, and their concentrations did not differ between the groups studied.ConclusionsHigh concentrations of intravitreal nucleotides ATP, ADP and AMP may be related to the pathogenesis of sight‐threatening forms of DR.
Pet ownership is associated with increased risk of non‐atopic asthma and reduced risk of atopy in childhood: findings from a UK birth cohort
Authors: Collin S. M. , Granell R. , Westgarth C. , Murray J. , Paul E. , Sterne J. A. C. , John Henderson A. 
Published: July 2014

SummaryBackgroundStudies have shown an inverse association of pet ownership with allergy but inconclusive findings for asthma.ObjectiveTo investigate whether pet ownership during pregnancy and childhood was associated with asthma and atopy at the age of 7 in a UK population‐based birth cohort.MethodsData from the Avon Longitudinal Study of Parents and Children (ALSPAC) were used to investigate associations of pet ownership at six time points from pregnancy to the age of 7 with asthma, atopy (grass, house dust mite, and cat skin prick test) and atopic vs. non‐atopic asthma at the age of 7 using logistic regression models adjusted for child's sex, maternal history of asthma/atopy, maternal smoking during pregnancy, and family adversity.ResultsA total of 3768 children had complete data on pet ownership, asthma, and atopy. Compared with non‐ownership, continuous ownership of any pet (before and after the age of 3) was associated with 52% lower odds of atopic asthma [odds ratio (OR) 0.48, 95% CI 0.34–0.68]. Pet ownership tended to be associated with increased risk of non‐atopic asthma, particularly rabbits (OR 1.61, 1.04–2.51) and rodents (OR 1.86, 1.15–3.01), comparing continuous vs. non‐ownership. Pet ownership was consistently associated with lower odds of sensitization to grass, house dust mite, and cat allergens, but rodent ownership was associated with higher odds of sensitization to rodent allergen. Differential effects of pet ownership on atopic vs. non‐atopic asthma were evident for all pet types.Conclusions and Clinical RelevancePet ownership during pregnancy and childhood in this birth cohort was consistently associated with a reduced risk of aeroallergen sensitization and atopic asthma at the age of 7, but tended to be associated (particularly for rabbits and rodents) with an increased risk of non‐atopic asthma. The opposing effects on atopy vs. non‐atopic asthma might be considered by parents when they are deciding whether to acquire a pet.
Oral immunotherapy for food allergy: mechanisms and role in management
Authors: Nowak‐Węgrzyn A. , Albin S. 
Published: July 2014

SummaryWith the emergence of food allergy as an important public health problem, it has become clear that there is an unmet need in regard to treatment. In particular, IgE‐mediated food allergy that is associated with risk of fatal anaphylaxis has been the subject of multiple studies in the past decade. The growing body of evidence derived from multiple centres and various study designs indicates that for IgE‐mediated food allergy, immunomodulation through food immunotherapy is possible; however, the extent of protection afforded by such treatment is highly variable. At this time, the capacity for food immunotherapy to restore permanent tolerance to food has not been demonstrated conclusively. This review will discuss these topics as they apply to the most important studies of food oral immunotherapy.
Dynamin inhibition interferes with inflammasome activation and cytokine gene expression inStreptococcus pyogenes-infected human macrophages
Authors: Latvala S , Mäkelä S M , Miettinen M , Charpentier E , Julkunen I 
Published: July 2014

SummaryIn the present study, we have analysed the ability of Streptococcus pyogenes [Group A streptococcus (GAS)] to activate the NACHT-domain-, leucine-rich repeat- and PYD-containing protein 3 (NALP3) inflammasome complex in human monocyte-derived macrophages and the molecules and signalling pathways involved in GAS-induced inflammatory responses. We focused upon analysing the impact of dynamin-dependent endocytosis and the role of major streptococcal virulence factors streptolysin O (SLO) and streptolysin S (SLS) in the immune responses induced by GAS. These virulence factors are involved in immune evasion by forming pores in host cell membranes, and aid the bacteria to escape from the endosome–lysosome pathway. We analysed cytokine gene expression in human primary macrophages after stimulation with live or inactivated wild-type GAS as well as with live SLO and SLS defective bacteria. Interleukin (IL)-1β, IL-10, tumour necrosis factor (TNF)-α and chemokine (C-X-C motif) ligand (CXCL)-10 cytokines were produced after bacterial stimulation in a dose-dependent manner and no differences in cytokine levels were seen between live, inactivated or mutant bacteria. These data suggest that streptolysins or other secreted bacterial products are not required for the inflammatory responses induced by GAS. Our data indicate that inhibition of dynamin-dependent endocytosis in macrophages attenuates the induction of IL-1β, TNF-α, interferon (IFN)-β and CXCL-10 mRNAs. We also observed that pro-IL-1β protein was expressed and efficiently cleaved into mature-IL-1β via inflammasome activation after bacterial stimulation. Furthermore, we demonstrate that multiple signalling pathways are involved in GAS-stimulated inflammatory responses in human macrophages.