bluuebunny/crossref_metadata_2025_split huggingface dataset:
Localized Multiple Glomus Tumors of the Face and Oral Mucosa
Authors: Yu Hee‐Joon , Kwon Sang‐Jin , Bahn Jae‐Yong , Park Jong‐Min , Park Yong Wook 
Published: April 2015

AbstractWe describe a 54‐year‐old patient with an unusual localization of localized multiple glomus tumors. She had several nodules on the left mandibular area, lower lip, and anterior part of the buccal mucosa. A biopsy taken from the left mandibular area showed cystically dilated vessels lined by endothelial cells and a few outer layers of glomus cells in the dermis to subcutis. Localized multiple glomus tumors are rare, and both their facial and oral mucocal localization are extremely rare.
Solid Facial Edema in a Patient with Rosacea
Authors: Uhara Hisashi , Kawachi Shigeo , Saida Toshiaki 
Published: April 2015

AbstractWe report a 53‐year old man with symmetrical nonpitting edema, conjunctivitis, and acneiform eruptions on the face. Histopathological examination showed perifollicular lymphohistiocytic infiltration and telangiectasias in the upper dermis. Loosely aggregated non‐caseating granulomas were scattered through the dermis; some of them were seen in the perifollicular regions. The patient was treated with fleroxacin (100 mg/day, orally) for two weeks with a marked reduction of both solid facial edema and periorbital edema.
A Retrospective Survey of Mucocutaneous Manifestations of HIV Infection in Malaysia: Analysis of 182 Cases
Authors: Jing Wang 
Published: April 2015

AbstractA retrospective analysis of 182 HIV positive Malaysians was done in two centers, the University Hospital Kuala Lumpur (UHKL) and the General Hospital Kuala Lumpur (GHKL) from March 1997 to February 1998. Demographic and clinical data were analyzed. The analysis showed that 130 out of 182 patients had mucocutaneous disorders (71.4%). In the study there were 125 males (96.2%) and 5 females (3.8%). The majority of the patients were in the age group from 20 to 50 years. The patients who presented with mucocutaneous disease also had low CD4+ T lymphocyte counts, and most of them had AIDS defining illnesses. The number of cases with generalized hyperpigmentation was very high (35.7%), followed by papular eruptions (29.1%) and xerosis (27.5%). Seborrheic dermatitis was seen in 19.2% of the cases and psoriasis in 7.7%. The most common infections were oral candida 35.7%, tinea corporis and onychomycosis 9.9%, and herpes infection 4.3%. However, mucocutaneous manifestations of Kaposi's sarcoma were rare. The results suggested that mucocutaneous findings are useful clinical predictors of HIV infection or a sign of the presence of advanced HIV infection.
Herpes Zoster Infection Complicated by Motor Paralysis
Authors: Akiyama Naoko 
Published: April 2015

AbstractWe reviewed a total of 1,432 patients diagnosed with cutaneus herpes zoster at Hyogo College of Medicine Hospital between 1989 and 1997 for epidemiologic assessment and outcome in patients with zoster paralysis referred for rehabilitation. Of the 1,432 herpes zoster patients (624 males and 808 females, mean age 54.3 years), 12 were referred to our department of rehabilitation medicine for muscle weakness: one had myelitis, and eleven others had lower motor neuron damage. Except for one 43‐year‐old man with myelodysplastic syndrome, all the lower motor neuron deficit patients were over 60 years of age. Involved myotomes were more widespread than involved dermatomes in eight patients. Electromyography in four patients demonstrated denervation of involved muscles. Five patients experienced complete or near complete recovery from their muscle weakness. The muscle weakness related to herpes zoster was occasionally diagnosed by electromyography as motor neuron damage. Manifestations of motor neuron complications were not noticed but might in fact be more common than was the clinical muscle weakness.
Palmoplantar Pustulosis with Pustulotic Arthroosteitis Involving Temporal Osteomyelitis and Meningitis
Authors: Seno Akemi , Arata Jiro , Matsuura Yoshiko , Suemitsu Ichizou 
Published: April 2015

AbstractA 46‐year‐old man who had been suffering from palmoplantar pustulosis (PPP) for 3 years had anterior chest pain and left temporal pain from six months after the onset of his disease. A bone scan revealed abnormal uptake at the sternoclavicular joint and left temporal region. The head CT and MRI gave the diagnosis of temporal osteomyelitis with meningitis and myositis. His headache continued even after tonsillectomy and was effectively treated with cyclosporine A (3 mg/kg/day). Oral cyclosporine A was beneficial for the osteomyelitis and skin lesions. Sterile lytic bone lesions occurring most often at the sternocostoclavicular joint have been associated with PPP. However, there have been no reports of a PPP patient with temporal osteomyelytic involvement.
Inhibitory Effects of Alpinia speciosa K. SCHUM on the Porphyrin Photooxidative Reaction
Authors: Liao Ming‐Ching , Arakaki Hajime , Li Yaping , Takamiyagi Atsushi , Tawata Shinkichi , Aniya Yoko , Sakurai Hiromu , Nonaka Shigeo 
Published: April 2015

AbstractIt is thought that the β‐carotene defense mechanism against photosensitivity involves the inhibition of singlet oxygen formation, a kind of active oxygen. When we screened chemical substances obtained from plants indigenous to Okinawa, known to have residents with the longest life span in Japan, we found that Alpinia speciosa K. SCHUM (Japanese name: gettou), which is used as a food preservative, has an activity similar to that of β‐carotene. We measured the amount of lipid peroxide (LPO) formed from a hematoporphyrin‐containing rat liver microsomal suspension irradiated with visible light. The inhibitory effect of Alpinia speciosa on LPO formation was confirmed when the addition of increasing concentrations of Alpinia speciosa extract led to a decrease in the amount of LPO formed. Moreover, the reaction mechanism that affects the amount of singlet oxygen formed was measured, and the effect of the extract was determined by the ESR trapping technique. It was found that the extract effectively inhibited the formation of singlet oxygen. The extract of Alpinia speciosa contains dihydro‐5,6‐dehydrokawain. It was confirmed that dihydro‐5,6‐dehydrokawain, which is a water‐soluble compound, has singlet oxygen quenching activity. We synthesized five derivatives of kawain and found that dimethyl [6‐(2‐phenylethyl)‐2‐oxo‐2H‐pyran‐4‐yl] phosphorothionate has the strongest singlet oxygen quenching activity. The use of the compound from Alpinia speciosa that exhibits singlet oxygen quenching activity as an inhibitory agent of the phototoxic reaction in porphyria is expected.
Spitz Nevus on the Palmar Surface
Authors: Banba Keisuke , Fujioka Akira , Takasu Hiroshi , Ishibashi Akira , Ohta Midori 
Published: April 2015

AbstractRelatively little is known about the incidence of Spitz nevus on palmar surfaces. This report places a case study in the context of the Japanese literature regarding the occurrence of Spitz nevus on palmar surfaces. Although the proportion of palms and soles in relation to the body surface is about 5%, the incidence of the Spitz nevus was 2%. The mean age at onset was 17.8 years, and all 4 cases were women. The clinical features were a black macule or flatly elevated small modules. The size of the lesions was relatively small, extending from 3.5 mm to 8.0 mm. Although the backs of the hands and insteps have almost the same area as the palms and soles, the incidence of onset in these regions was 6.3% (13 cases). We thus concluded that Spitz nevus tends to be rare on palms and soles.
Multiple Fibroepithelial Basal Cell Carcinoma of Pinkus Associated with Seborrheic Keratosis in a Nevoid Distribution
Authors: Rodriguez Rene Alejandro , Neto Cyro Festa 
Published: April 2015

AbstractWe describe a patient with multiple fibroepithelial basal‐cell carcinoma (FEBCC) associated with seborrheic keratosis distributed in a neviform fashion on the left side of the body and clinically resembling skin tags.
A Rare Association of Systemic Sclerosis with Psoriasis Vulgaris
Authors: Yamamoto Toshiyuki , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractThree patients with systemic sclerosis (SSc) and psoriasis vulgaris were evaluated. The onset of psoriasis preceded by 3–7 years the onset of SSc in all cases. All the patients presented diffuse scleroderma, accompanied by lung and esophageal involvement in two cases. Sjögren's syndrome occurred in one case. Myalgia developed with the onset of SSc in two patients. The PASI score was not high (mean; 5.2), implying that the degree of psoriasis was not severe in these cases. However, this might have been due to the systemic prednisolone administered for myalgia.
Photosensitivity in HIV‐Infected Individuals
Authors: Vin‐Christian Kirsten , Epstein John H. , Maurer Toby A. , McCalmont Timothy H. , Berger Timothy G. 
Published: April 2015

AbstractObjectiveTo characterize photosensitivity in HIV‐infected individuals using minimal erythema dosage (MED) UVA (ultraviolet A light) and UVB (ultraviolet B light) photoprovocation light testing.DesignProspective, controlled analytical studySettingUniversity of California, San Francisco, between March 1995 and January 1997.Patients13 HIV‐seropositive patients with clinical and pathological features consistent with photodermatitis, 13 HIV‐seropositive patients with biopsy‐proven eosinophilic foliculitis (EF), and 10 HIV‐seropositive patients with CD4 (T helper cell) count below 200 cells/uL and no history of photosensitivity or EF.InterventionEach patient underwent MED testing for UVB. All 13 patients with suspected photodermatitis underwent full photochallenge testing with UVA and UVB for up to 10 consecutive week days.ResultsMean MED to UVB in patients with clinical photosensitivity and EF was lower (p=0.004 and p=0.022 respectively) than that of patients without a clinical history of photodermatitis. There were no significant differences in mean CD4 count or Fitzpatrick skin type. Positive photochallenge tests (papular changes at site of provocative light testing) to UVB (9 of 13 patients) were much more common than reactions to UVA (3 of 13 patients) in the photodermatitis group. All patients with clinically active photodermatitis developed papular changes at the site of UVB photochallenge testing, but only 1 of 5 patients with photodermatitis in remission developed papular changes with UVB photochallenge testing. Seven of the 13 patients with photodermatitis had Native American ancestry. Photosensitive patients were commonly taking trimethoprim‐sulfamethoxazole (TMP‐SMX), but no more commonly than EF or control patients.ConclusionsPhotosensitivity in HIV‐infected individuals appears to be a manifestation of advanced disease. Most patients are sensitive to UVB. The most severely affected individuals are both UVB and UVA sensitive, and may show reactions to visible light. A significant Native American ancestry may be a risk factor for development of photodermatitis in patients with advanced HIV disease. Finally, patients with eosinophilic folliculitis may be subclinically photosensitive.
Expression of 27 KD, 65 KD and 72/73 KD Heat Shock Protein in Atopic Dermatitis: Comparison with Those in Normal Skin and Contact Dermatitis
Authors: Ghoreishi Mehran , Yokozeki Hiroo , Hua Wu Ming , Nishioka Kiyoshi 
Published: April 2015

AbstractThe expression of Heat Shock Protein (HPS) 72/73, HSP65 and HSP27 in skin lesions of atopic dermatitis (n=21) was studied and compared with that in contact dermatitis (n=18) and normal skin (n=9). Keratinocytes in the whole epidermis expressed both HSP65 and HSP72/73 with a membranous, cytoplasmic or nuclear/perinuclear staining pattern much more intensely in atopic dermatitis than in contact dermatitis and normal subjects. In approximately half of the subjects with atopic dermatitis, infiltrating cells in the dermis expressed HSP65 and HSP72/73; this was not observed in contact dermatitis. HSP27 was expressed in the upper epidermis with a cytoplasmic or nuclear/perinuclear staining pattern in all groups. HSP27 was not expressed by infiltrating cells. A clinical evaluation of atopic dermatitis showed that more severe types of atopic dermatitis expressed more intense expression of HSP65 and HSP72/73, but not HSP27, in their skin lesions. These findings suggested that HSP65 and HSP72/73 may play roles in the pathogenesis of atopic dermatitis.
A Case of Classic Kaposi's Sarcoma in a Japanese Man: Detection of Human Herpes Virus 8 (HHV‐8) Infection by Means of Polymerase Chain Reaction and Immunofluorescence Assay
Authors: Yamada Yozo , Funasaka Yoko , Nishioka Eri , Okuno Toshiomi , Ichihashi Masamitsu 
Published: April 2015

AbstractThe recently discovered human herpes virus 8 (HHV‐8) has been implicated in the pathogenesis of Kaposi's sarcoma (KS). Because classic KS in Japan is rare and the detection of HHV‐8 DNA by polymerase chain reaction (PCR) has heen successful only in limited cases, the frequency and role of HHV‐8 infection in KS in Japan remain unclear. Herein we report a case of classic KS in a Japanese man whose HHV‐8 infection was confirmed by the detection of lesional viral DNA and serum antibodies against lytic antigen.
Successful Mapping of Lymphorrhea Using Patent Blue Dye after Lymph Node Dissection for Malignant Melanoma
Authors: Setoyama Mitsuru , Shimada Hidehiko , Kanzaki Tamotsu 
Published: April 2015

AbstractPatent blue is a dye that has been used for intraoperative lymphatic mapping. We used this mapping method on a patient with lymphorrhea after groin dissection. We easily detected the lymphatic channel causing lymphorrhea and successfully ligated it. This technique may have great merit for treating of lymphorrhea.
Late Onset Hyalinosis Cutis et Mucosae
Authors: Hashimoto Ken , Su W.P. Daniel , Wang Paul W‐S , Eto Hikaru 
Published: April 2015

AbstractTwo cases of non‐familial, late onset (50 and 62‐years‐old) hyalinosis cutis et mucosae were studied and compared with classical early onset cases. Late onset cases showed essentially the same histological and ultrastructural features described for early onset cases. The late onset variety should be distinguished from other diseases; they resemble systemic amyloidosis and sometimes the adult form of colloid milium.
Salivary Gland MALT Lymphoma Associated with Helicobacter pylori Infection in a Patient with Sjögren's Syndrome
Authors: Nishimura Masae , Miyajima Susumu , Okada Natsuko 
Published: April 2015

AbstractWe report a case of salivary gland MALT lymphoma in Sjögren's syndrome associated with localized H. pylori infection. A 76–year‐old woman had a history of bilateral cheek masses for two years. Histologically, the parotid glands were invaded by numerous centrocyte‐like cells to form lymphoepithelial lesions. The tumor cells showed immunohistological differentiation into B cells. Southern blotting demonstrated immunoglobulin gene rearrangement. These results indicated that the tumors were MALT lymphoma. H. pylori, as assessed by the urease test (CLO test; BML Ltd., Tokyo, Japan), was positive in the tumor specimen. After wide local excision of the tumors followed by radio therapy and oral administration of antibiotics and proton pump inhibitor, no evidence of recurrence was found during the 24–months of follow up. H. pylori infection in the salivary gland is rare, although the source of infection and transmission of H. pylori organisms has been thought to be the oral cavity. We discussed the association between H. pylori infection and salivary gland MALT lymphoma. The microorganism may play a role as an additional antigenic stimulus for the development of salivary gland MALT lymphoma as well as for the development of gastric MALT lymphoma. This means that H. pylori can play a role in lymphoma progression as booster of B cell lymphoproliferation.
A Case of Acrodermatitis Enteropathica
Authors: Öztürkcan Serap , İçağasioğlu Dilara , Akyol Melih , Cevit Ömer 
Published: April 2015

AbstractAcrodermatitis enteropathica is a rare hereditary disorder affecting zinc metabolism that is characterized by dermatitis, alopecia, gastrointestinal disturbances, eye infections, and growth failure. We report a 17‐month‐old girl with acrodermatitis enteropathica. Physical examination showed a cutaneous eruption consisting of vesiculobullous and psoriasiform skin lesions symmetrically distributed in the perioral, acral, and perineal areas. Her plasma zinc level was decreased (75 μg/dl), but within the normal range (60.00–135.00 μg/dl). The patient was given zinc sulfate 50 mg/day. At the end of two months, she had significantly improved.
Do Training‐Dependent Differences in Perspiration Exist between Healthy and Atopic Subjects?
Authors: Stern Ursula M. , Hornstein Otto P. , Salzer Bernd 
Published: April 2015

AbstractSweating (perspiratio sensibilis) serves predominantly for thermoregulation and is triggered, among other stimuli, by physical stress. Although consensus on sex‐dependent differences in sweating has not been reached so far and recent studies revealing abnormal diminution of the sweating capacity in atopic subjects are mainly based on heat exposure experiments, the influence of endurance training on perspiration in atopics has not yet been evaluated. Using a special sweat collector device reliable even during intensive body movement, we compared the sweat production of age‐matched male and female healthy controls (14 m, 10 f) to that of in‐patients with atopic eczema (AE: 14 m, 10 f) during and 5 min after physical exercise (30 min) with a bicycle ergometer under standardized experimental conditions. The individual stress limit was determined by a previous endurance test including repeated lactate blood level measurements and continuous heart rate control. Informed consent was obtained from every participant in the study. One half of both the patients and the controls underwent three week endurance training, and the preceding sweat measurements were repeated in all patients and controls after the training period under identical conditions. On average, the healthy males perspired nearly twice as much as the corresponding females (p<0.0016). Highly significant mean differences of maximum sweat secretion rates were also found between the atopics and the controls. Healthy individuals of both sexes perspired nearly three times as much as did the patients with AE (males: p<0.0004; females: p<0.00009). Among the atopics there were remarkable, yet statistically insignificant, sexual differences in sweat production. After three weeks, sweating rates were similar to the initial ones in the training group as well as in the non‐trained control group. Gender differences in perspiration do not only exist betweeen healthy males and females but also in patients with atopic skin disorder, yet the latter ones at significantly lower levels as compared to healthy control subjects. No influence of a three‐week‐exercise phase on sweat secretion in atopics and controls could be proven. For designing further studies on intra‐ or intersexual differences of drug‐independent perspiration, standardized physical stress can be recommended as an experimental prerequisite for sweat measurements.
Topical δ‐Aminolevulinic Acid‐Based Photodynamic Therapy for Japanese Actinic Keratoses
Authors: Itoh Yoshiyasu , Ninomiya Yoshiharu , Henta Tetsuro , Tajima Shingo , Ishibashi Akira 
Published: April 2015

AbstractBased on the opinion that 5‐aminolevulinic acid‐based photodynamic therapy (ALA‐PDT) may be disadvantageous to Oriental patients with dark skin, including Japanese, because the competing chromophore melanin inhibits the photochemical reaction, we assessed the therapeutic effects when Japanese AK were treated with ALA‐PDT. Fifty‐three lesions in ten patients were followed up for over one year. The cure rates of AK on the face including the neck and on extremities were 81.8% and 55.6%, respectively. The results were approximately the same cure rates as those reported for AK in Caucasian patients. However, a larger number of treatment sessions were required. In the red light range, incoherent light including 630 nm and 670 nm is superior to 630 nm laser light.
Skin Ulcer at the Blunt Apex of a Giant Warthin's Tumor
Authors: Abraham Zeev , Rozenbaum Michael , Keren Ruth 
Published: April 2015

AbstractAn unusual finding of Warthin's tumor or papillary cystadenoma lymphomatosum with ulceration of the overlying skin is described in a patient who refused surgical removal of this growth. The present article is the second case published in the English language dermatological literature on this fascinating tumor. To our knowledge, the clinical presentation and course of the disorder in this individual are unique.
Small Congenital Nevi Associated with Melanoma: Case Reports and Considerations
Authors: Betti Roberto , Inselvini Elena , Vergani Raffaella , Crosti Carlo 
Published: April 2015

AbstractMelanocytic nevi, both congenital and acquired, are considered to be precursors of melanomas. Data about the malignant potential of these nevi are conflicting, particularly with reference to the nevus of the smallest size. Patients with preexisting melanocytic nevi (both congenital and acquired) have risks of developing melanoma that differ from those of subjects without them. The purpose of this study was to verify the presence of melanoma in preexisting nevi both congenital (congenital nevus associated melanoma) (CNAM) and acquired (ANAM). In particular, we investigated melanomas associated with small congenital nevi (SCN). A cohort of 190 patients with primary melanomas was studied. Congenital nevi were called “small” (SCN) when their diameters were less than 1.5 cm. Epiluminescence microscopy (ELM) was performed to further improve the clinical diagnosis and to observe the more subtle changes in the preexisting nevi. Forty of the 190 cases of melanoma were associated with preexisting nevi; of these, 15 had congenital features with a CNAM largest diameter of 1.5 cm. These 15 cases were melanomas of the superficial type with a mean tumor thickness lower than that of ANAM (0.33 vs 1.50). There were no differences between the locations of CNAM and other melanomas. Male patients were significantly more affected. ELM microscopy permitted us to detect the early malignant changes in nevi and thus to improve our diagnosis. A high percentage of small congenital nevi were found to be associated with melanomas. They may be considered as melanomas precursors. Because of their large number and frequency, prophylactic removal of all SCN is not feasible. However, they should be removed as soon as possible when clinical or ELM changes are observed.
Two Cases of Confluent and Reticulate Papillomatosis: Successful Treatments of One Case with Cefdinir and Another with Minocycline
Authors: Yamamoto Asayo , Okubo Yukari , Oshima Haruko , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractThe present report presents two cases of confluent and reticulate papillomatosis. Case 1 was a 24‐year‐old man who had suffered from skin eruptions for six months, and Case 2 was a 19‐year‐old woman who had had this disease for three days. In both patients, reticular dark brown papules, accompanied by mild keratosis and infiltration, spread from the trunk to the neck and upper arm. Direct light microscopy did not detect the presence of any fungi, and histopathological examinations confirmed hyperkeratosis, acanthosis, papillomatosis, and mild small‐round‐cell infiltration. Thus, these patients were diagnosed as confluent and reticulate papillomatosis. Neither one had diabetes or thyroid dysfunction. In Case 1, cefdinir was effective, and in Case 2, minocycline hydrochloride and ketoconazole were effective. To the best of our knowledge, this was the first documented case of confluent and reticulate papillomatosis responding to cefdinir.