bluuebunny/crossref_metadata_2025_split huggingface dataset:
A temperate super-Jupiter imaged with JWST in the mid-infrared
Authors: Matthews E. C. , Carter A. L. , Pathak P. , Morley C. V. , Phillips M. W. , P. M. S. Krishanth , Feng F. , Bonse M. J. , Boogaard L. A. , Burt J. A. , Crossfield I. J. M. , Douglas E. S. , Henning Th. , Hom J. , Ko C.-L. , Kasper M. , Lagrange A.-M. , Petit dit de la Roche D. , Philipot F. 
Published: July 2024

AbstractOf the approximately 25 directly imaged planets to date, all are younger than 500 Myr, and all but six are younger than 100 Myr (ref. 1). Eps Ind A (HD209100, HIP108870) is a K5V star of roughly solar age (recently derived as 3.7–5.7 Gyr (ref. 2) and $${3.5}_{-1.3}^{+0.8}$$

3.5

−
1.3

+
0.8

Gyr (ref. 3)). A long-term radial-velocity trend4,5 and an astrometric acceleration6,7 led to claims of a giant planet2,8,9 orbiting the nearby star (3.6384 ± 0.0013 pc; ref. 10). Here we report JWST coronagraphic images which reveal a giant exoplanet that is consistent with these radial and astrometric measurements but inconsistent with the previously claimed planet properties. The new planet has a temperature of approximately 275 K and is remarkably bright at 10.65 and 15.50 µm. Non-detections between 3.5 and 5.0 µm indicate an unknown opacity source in the atmosphere, possibly suggesting a high-metallicity, high carbon-to-oxygen ratio planet. The best-fitting temperature of the planet is consistent with theoretical thermal evolution models, which were previously untested at this temperature range. The data indicate that this is probably the only giant planet in the system, and therefore we refer to it as b, despite it having significantly different orbital properties than the previously claimed planet b.
A structured course of disease dataset with contact tracing information in Taiwan for COVID-19 modelling
Authors: Wu Yu-Heng , Nordling Torbjörn E. M. 
Published: July 2024

AbstractThe COVID-19 pandemic has flooded open databases with population-level data. However, individual-level structured data, such as the course of disease and contact tracing information, is almost non-existent in open databases. Publish a structured and cleaned COVID-19 dataset with the course of disease and contact tracing information for easy benchmarking of COVID-19 models. We gathered data from Taiwanese open databases and daily news reports. The outcome is a structured quantitative dataset encompassing the course of the disease of Taiwanese individuals, alongside their contact tracing information. Our dataset comprises 579 confirmed cases covering the period from January 21, to November 9, 2020, when the original SARS-CoV-2 virus was most prevalent in Taiwan. The data include features such as travel history, age, gender, symptoms, contact types between cases, date of symptoms onset, confirmed, critically ill, recovered, and dead. We also include the daily summary data at population-level from January 21, 2020, to May 23, 2022. Our data can help enhance epidemiological modelling.
Multi-organ transcriptomic profiles and gene-regulation network underlying vibriosis resistance in tongue sole
Authors: Chen Quanchao , Ma Xinran , Wang Jie , Shi Meng , Hu Guobin , Chen Songlin , Zhou Qian 
Published: July 2024

AbstractVibrio spp. are major pathogens responsible for mortality and disease in various marine aquaculture organisms. Effective disease control and genetic breeding strategies rely heavily on understanding host vibriosis resistance mechanisms. The Chinese tongue sole (Cynoglossus semilaevis) is economically vital but suffers from substantial mortalities due to vibriosis. Through continuous selective breeding, we have successfully obtained vibriosis-resistant families of this species. In this study, we conducted RNA-seq analysis on three organs, including liver, spleen and intestine from selected resistant and susceptible tongue soles. Additionally, we integrated these data with our previously published RNA-seq datasets of skin and gill, enabling the construction of organ-specific transcriptional profiles and a comprehensive gene co-expression network elucidating the differences in vibriosis resistance. Furthermore, we identified 12 modules with organ-specific functional implications. Overall, our findings provide a valuable resource for investigating the molecular basis of vibriosis resistance in fish, offering insights into target genes and pathways essential for molecular selection and genetic manipulation to enhance vibriosis resistance in fish breeding programs.
Experimental study and analysis of CO2 and SO2 absorption in various water-based nanofluids by response surface methodology
Authors: Karamian Soroush , Esmaeilzadeh Feridun , Mowla Dariush , Esmaeili-Faraj Seyyed Hamid , Arjomand Alireza 
Published: July 2024

AbstractThe absorption of acidic gases in the oil and gas industries is important due to their toxicity and corrosive effects. Recently, the application of nanofluids based on aqueous or organic solvents as absorbents has been examined by a variety of researchers. In this study, a single bubble column was exploited to study the effect of water-based nanofluids on the absorption processes of SO2 and CO2 using response surface methodology (RSM) based on Box-Behnken three-level experiment design. With this in mind, CO2 and SO2 are separately injected at the bottom of a bubble column filled with one of the nanofluids: Al2O3-water, SiO2-water, or ZnO-water for each experiment. Then, the rate of SO2 or CO2 absorption in the nanofluids has been elucidated. The effect of important parameters including the weight fraction of the nanoparticles (NPs) (0.01, 0.055, and 0.1 wt.%), gas–liquid contact time (150, 300, and 450 s), and the diameter of nozzle for gas injection (0.46, 0.57, and 0.68 mm) have been studied. Results revealed that the maximum molar flux of both gases was observed in the ZnO-water nanofluid, followed by the SiO2-water nanofluid. In addition, increasing the nanoparticle mass fraction and the bubble size causes the molar flux to rise. However, increasing the gas–liquid contact time causes the molar flux of the mentioned gases to decrease. Finally, a set of the accurate equations has been proposed to predict the molar flux of SO2 and CO2 in the various nanofluids assessed in this work.
Litho-structural interpretation of aeromagnetic anomalies reveals potential for mineral exploration in Tizi n'Test Region, Western High Atlas, Morocco
Authors: Dadi Bouchra , Faik Farid , Boutaleb Said , Abia El Hassan , Azzab Driss El , Ouchchen Mohammed , Mamouch Younes , Echogdali Fatima Zahra , Mickus Kevin L. , Abioui Mohamed , Sobh Mohamed , Hassan Soha 
Published: July 2024

AbstractThis study interprets aeromagnetic data from the Tizi n'Test area in the High Atlas massif of Morocco, aiming to gain insights into its litho-structural architecture and implications for mineral exploration and mining. We employed six different analytical techniques to the residual magnetic field data, including reduction to the pole (RTP), upward continuation, total horizontal derivative, Tilt angle, Centre for Exploration Targeting (CET) analysis, and Euler deconvolution. Our analyses differentiated the study area into three magnetic domains: the eastern Ouzellarh block, characterized by positive anomalies, a central domain characterized by a negative magnetic signature demarcating the transitional zone between the Anti-Atlas and the High Atlas separated by the Ouchden fault: and the western domain, represented by the Tichka massif. The application of total horizontal derivative, tilt angle, and a combination of filters in ternary image formats (Tilt angle, upward continuation 1000 + Tilt angle and upward continuation 3000 + Tilt angle) revealed both known and previously unidentified geological lineaments, mapping structural complexity across various orientations (NE–SW, NNE–SSE, E–W, NW–SE, and N–S). The CET grid analysis method unveiled the structural complexity, highlighting the geodynamic evolution of the region. Particularly, the Ouchden fault delineates a magnetic domain divide between the ancient High Atlas and the Ouzellarh block (Anti-Atlas). Furthermore, Euler deconvolution indicated magnetic source depths ranging from 52 m in the western domain of the Tichka massif to 6560 m in the Ouzellarh block. A comprehensive structural scheme, classified by C-A fractal analysis, identified zones favourable for exploration and mining, particularly along the Ouchden fault, Tizi n'Test, NE-SW trending lineaments in the northwestern domain, as well as along the Tichka granite’s margin.
Eleven neurology-related proteins measured in serum are positively correlated to the severity of diabetic neuropathy
Authors: Bäckryd Emmanuel , Themistocleous Andreas , Larsson Anders , Gordh Torsten , Rice Andrew S. C. , Tesfaye Solomon , Bennett David L. , Gerdle Björn 
Published: July 2024

AbstractAbout 20% of patients with diabetes suffer from chronic pain with neuropathic characteristics. We investigated the multivariate associations between 92 neurology-related proteins measured in serum from 190 patients with painful and painless diabetic neuropathy. Participants were recruited from the Pain in Neuropathy Study, an observational cross-sectional multicentre study in which participants underwent deep phenotyping. In the exploration cohort, two groups were defined by hierarchical cluster analyses of protein data. The proportion of painless vs painful neuropathy did not differ between the two groups, but one group had a significantly higher grade of neuropathy as measured by the Toronto Clinical Scoring System (TCSS). This finding was replicated in the replication cohort. Analyzing both groups together, we found that a group of 11 inter-correlated proteins (TNFRSF12A, SCARB2, N2DL-2, SKR3, EFNA4, LAYN, CLM-1, CD38, UNC5C, GFR-alpha-1, and JAM-B) were positively associated with TCSS values. Notably, EFNA4 and UNC5C are known to be part of axon guidance pathways. To conclude, although cluster analysis of 92 neurology-related proteins did not distinguish painful from painless diabetic neuropathy, we identified 11 proteins which positively correlated to neuropathy severity and warrant further investigation as potential biomarkers.
General instability of dipeptides in concentrated sulfuric acid as relevant for the Venus cloud habitability
Authors: Petkowski Janusz J. , Seager Maxwell D. , Bains William , Seager Sara 
Published: July 2024

AbstractRecent renewed interest in the possibility of life in the acidic clouds of Venus has led to new studies on organic chemistry in concentrated sulfuric acid. We have previously found that the majority of amino acids are stable in the range of Venus’ cloud sulfuric acid concentrations (81% and 98% w/w, the rest being water). The natural next question is whether dipeptides, as precursors to larger peptides and proteins, could be stable in this environment. We investigated the reactivity of the peptide bond using 20 homodipeptides and find that the majority of them undergo solvolysis within a few weeks, at both sulfuric acid concentrations. Notably, a few exceptions exist. HH and GG dipeptides are stable in 98% w/w sulfuric acid for at least 4 months, while II, LL, VV, PP, RR and KK resist hydrolysis in 81% w/w sulfuric acid for at least 5 weeks. Moreover, the breakdown process of the dipeptides studied in 98% w/w concentrated sulfuric acid is different from the standard acid-catalyzed hydrolysis that releases monomeric amino acids. Despite a few exceptions at a single concentration, no homodipeptides have demonstrated stability across both acid concentrations studied. This indicates that any hypothetical life on Venus would likely require a functional substitute for the peptide bond that can maintain stability throughout the range of sulfuric acid concentrations present.
Extraction optimization and reactivity of 7α-acetoxy-6β-hydroxyroyleanone and ability of its derivatives to modulate PKC isoforms
Authors: Isca Vera M. S. , Bangay Gabrielle , Princiotto Salvatore , Saraíva Lucília , dos Santos Daniel J. V. A. , García-Sosa Alfonso T. , Rijo Patrícia 
Published: July 2024

AbstractProtein kinase C is a family of kinases that play important roles in carcinogenesis. Medicinal plants from Plectranthus spp. (Lamiaceae) are a well-known source of interesting abietanes, such as 7α-acetoxy-6β-hydroxyroyleanone (Roy). This study aimed to extract and isolate Roy from P. grandidentatus Gürke, comparing two extraction methods (CO2 supercritical and ultrasound-assisted acetonic extraction), and design new royleanone derivatives for PKC modulation focusing on breast cancer therapy. The concentration of Roy in the extracts was determined by HPLC–DAD. The supercritical extraction method yielded 3.6% w/w, with the presence of 42.7 μg mg−1 of Roy (yield of 0.13%), while ultrasound-assisted acetonic extraction yielded 2.3% w/w, with the presence of 55.2 μg mg−1 of Roy (yield of 0.15%). The reactivity of Roy was investigated aiming at synthetizing new ester derivatives through standard benzoylation and esterification reactions. The benzoylated (Roy-12-Bz) and acetylated (Roy-12-Ac) derivatives in the C12 position were consistently prepared with overall good yields (33–86%). These results indicate the 12-OH position as the most reactive for esterification, affording derivatives under mild conditions. The reported di-benzoylated (RoyBz) and di-acetylated (RoyAc) derivatives were also synthesized after increasing the temperature (50 °C), reaction time, and using an excess of reagents. The cytotoxic potential of Roy and its derivatives was assessed against breast cancer cell lines, with RoyBz emerging as the most promising compound. Derivatization at position C-12 did not offer advantages over di-esterification at positions C-12 and C-6 or over the parent compound Roy and the presence of aromatic groups favored cytotoxicity. Evaluation of royleanones as PKC-α, βI, δ, ε, and ζ activators revealed DeRoy’s efficacy across all isoforms, while RoyPr showed promising activation of PKC-δ but not PKC-ζ, highlighting the influence of slight structural changes on isoform selectivity. Molecular docking analysis emphasized the importance of microenvironmental factors in isoform specificity, underscoring the complexity of PKC modulation and the need for further exploration.
Vitamin D3 suppresses Npt2c abundance and differentially modulates phosphate and calcium homeostasis in Npt2a knockout mice
Authors: Thomas Linto , Dissanayake Lashodya V. , Tahmasbi Maryam , Staruschenko Alexander , Al-Masri Sima , Dominguez Rieg Jessica A. , Rieg Timo 
Published: July 2024

AbstractVitamin D3 is clinically used for the treatment of vitamin D3 deficiency or osteoporosis, partially because of its role in regulating phosphate (Pi) and calcium (Ca2+) homeostasis. The renal sodium-phosphate cotransporter 2a (Npt2a) plays an important role in Pi homeostasis; however, the role of vitamin D3 in hypophosphatemia has never been investigated. We administered vehicle or vitamin D3 to wild-type (WT) mice or hypophosphatemic Npt2a−/− mice. In contrast to WT mice, vitamin D3 treatment increased plasma Pi levels in Npt2a−/− mice, despite similar levels of reduced parathyroid hormone and increased fibroblast growth factor 23. Plasma Ca2+ was increased ~ twofold in both genotypes. Whereas WT mice were able to increase urinary Pi and Ca2+/creatinine ratios, in Npt2a−/− mice, Pi/creatinine was unchanged and Ca2+/creatinine drastically decreased, coinciding with the highest kidney Ca2+ content, highest plasma creatinine, and greatest amount of nephrocalcinosis. In Npt2a−/− mice, vitamin D3 treatment completely diminished Npt2c abundance, so that mice resembled Npt2a/c double knockout mice. Abundance of intestinal Npt2b and claudin-3 (tight junctions protein) were reduced in Npt2a−/− only, the latter might facilitate the increase in plasma Pi in Npt2a−/− mice. Npt2a might function as regulator between renal Ca2+ excretion and reabsorption in response to vitamin D3.
Examination of phacoemulsification tips after different numbers of cataract surgeries
Authors: Revak Agnes , Nemeth Gabor , Korizs Judit , Gyulai Gergo , Abraham Agnes , Kiss Eva , Sohajda Zoltan 
Published: July 2024

AbstractTo compare unused phacoemulsification tips and those used different times with different techniques of cataract surgery (divide and conquer and chop), in vivo phacoemulsifications were performed with tips of different numbers of operation. These were compared with the same number of sterilized-only and unused tips with the help of an atomic force microscope. Comparison of roughness values (Sa, Sq), geometric and measurable flange length and surface was also performed (profile length %, area %). The differences between the parameters that can be measured during surgery (average ultrasound percentage, US ave %, Average Phaco Time, APT) were also analyzed. We found significant correlations between age and lens hardness (p = 0.0045), area % and APT (p = 0.03), between area % and US ave% (p = 0.03) and also between the two surgical techniques in terms of area% (p = 0.04) and US ave % (p < 0.01). Roughness increased with the number of uses. An increase in profile length% can be observed up to the twentieth operation. This can result from scratches and microscopic damages and also from abrasion and possible material additions on the surface of the needles. The divide and conquer technique causes less microscopic damage to the surface, and smaller average US energy is required during surgery.
Diversity and ecological niche model of malaria vector and non-vector mosquito species in Covè, Ouinhi, and Zangnanado, Southern Benin
Authors: Adoha Constantin Jésukèdè , Sovi Arthur , Padonou Germain Gil , Yovogan Boulais , Akinro Bruno , Accrombessi Manfred , Dangbénon Edouard , Sidick Aboubakar , Ossè Razaki , Tokponon Tachémè Filémon , Odjo Esdras Mahoutin , Koukpo Come Z. , Fassinou Arsène , Missihoun Antoine A. , Sominanhouin André , Messenger Louisa A. , Agboho Prudenciène A. , Akpodji Serge , Ngufor Corine , Cook Jackie , Agbangla Clément , Protopopoff Natacha , Kulkarni Manisha A. , Akogbéto Martin C. 
Published: July 2024

AbstractThe present study aimed to assess mosquito species diversity, distribution, and ecological preferences in the Covè, Ouinhi, and Zangnanado communes, Southern Benin. Such information is critical to understand mosquito bio-ecology and to focus control efforts in high-risk areas for vector-borne diseases. Mosquito collections occurred quarterly in 60 clusters between June 2020 and April 2021, using human landing catches. In addition to the seasonal mosquito abundance, Shannon's diversity, Simpson, and Pielou's equitability indices were also evaluated to assess mosquito diversity. Ecological niche models were developed with MaxEnt using environmental variables to assess species distribution. Overall, mosquito density was higher in the wet season than in the dry season in all communes. A significantly higher Shannon's diversity index was also observed in the wet season than in the dry seasons in all communes (p < 0.05). Habitat suitability of An. gambiae s.s., An. coluzzii, Cx. quinquefasciatus and Ma. africana was highly influenced by slope, isothermality, site aspect, elevation, and precipitation seasonality in both wet and dry seasons. Overall, depending on the season, the ecological preferences of the four main mosquito species were variable across study communes. This emphasizes the impact of environmental conditions on mosquito species distribution. Moreover, mosquito populations were found to be more diverse in the wet season compared to the dry season.
A high-performance sub-THz planar antenna array for THz sensing and imaging applications
Authors: Zubair Muhammad , Jabbar Abdul , Tahir Farooq A. , Kazim Jalil ur Rehman , Rehman Masood Ur , Imran Muhammad , Liu Bo , Abbasi Qammer H. 
Published: July 2024

AbstractTerahertz (THz) spectral region from 0.1 to 3 THz is envisaged to hold immense potential in the next generation of wireless technologies. Recently, research has focused on this terahertz gap, because of its unprecedented channel capacities. At the physical layer, the design complexities and fabrication of THz devices, especially antennas are the prime bottlenecks to realize its full potential. This article introduces a cost-effective, easy-to-fabricate, and reproducible sub-THz antenna design based on a single-layer planar printed circuit board technology. The antenna incorporates carefully designed quasi-cross slots and applied machine learning-assisted global optimization techniques to achieve the desired performance metrics. The antenna performance is elucidated through numerical simulations and verified through a rigorous in-house THz experimental framework around 100–110 GHz. The proposed antenna offers a peak gain of 13.90 dBi with less than 1 dB variation within the entire band of 100–110 GHz. The antenna holds the potential to achieve terabits per second data rates and futuristic high-resolution short-range THz imaging applications.
Molecular changes in endometrium origin stromal cells during initiation of cardiomyogenic differentiation induced with Decitabine, Angiotensin II and TGF- β1
Authors: Skliutė Giedrė , Staponkutė Giedrė , Skliutas Edvinas , Malinauskas Mangirdas , Navakauskienė Rūta 
Published: July 2024

AbstractStem cells’ differentiation toward cardiac lineage is a complex process dependent on various alterations in molecular basis and regulation pathways. The aim of the study is to show that endometrium-derived stromal cells – menstrual, endometrial and endometriotic, could be an attractive source for examination of the mechanisms underlying cardiomyogenesis. After treatment with Decitabine, Angiotensin II and TGF-β1, cells demonstrated morphological dedifferentiation into early cardiomyocyte-like cells and expressed CD36, CD106, CD172a typically used to sort for human pluripotent stem cell-derived cardiomyocytes. RT-qPCR revealed changed cells’ genetic profiles, as majority of cardiac lineage differentiation related genes and cardiac ion channels (calcium, sodium, potassium) coding genes were upregulated after 6 and 13 days of exposure. Additionally, analysis of expression of various signaling proteins (FOXO1, PDGFB, TGFBR1, mTOR, VEGFA, WNT4, Notch1) coding genes showed differences between cell cultures as they seem to employ distinct signaling pathways through differentiation initiation. Early stages of differentiation had biggest impact on cardiomyogenesis related proteins (Nkx-2.5, EZH2, FOXO3a, H3K9Ac) levels, as we noticed after conducting Western blot and as expected, early cardiac transcription factor Nkx-2.5 was highly expressed and localized in nucleus of differentiating cells. These findings led us to assess endometrium origin stromal cells’ potential to differentiate towards cardiomyogenic lineage and better understand the regulation of complex differentiation processes in ex vivo model systems.