bluuebunny/crossref_metadata_2025_split huggingface dataset:
A case report:Laparoscopic surgical treatment without myometrium incision of unruptured cornual pregnancy
Authors: Wang Jing , Zhu Ru 
Published: July 2024

Abstract

The cornual pregnancy is a rare but life-threatening disease of women. The traditional surgical methods are difficult to reduce the blood loss while preserving uterine integrity. We present a case of a 23-year-old woman complained of menopause for 53 days and vaginal spotting. The human chorionic gonadotropin level was 24953mIU/mL. Transvaginal ultrasound revealed a nechoic area with a germ approximately 15mm in length in the right cornua uteri (26*20mm),and primitive heart tube pulsations were visible. To reduce intraoperative bleeding and avoid damage to the myometrium,there are several key points for our conservative laparoscopic treatment.Tighten the sutures that were previously sewn at the base of the cornual pregnancy mass before transvaginal suction and curettage under the laparoscopic supervision.Fold and sew again outside the purse suture to achieve hemostasis.The operation time was about 20 min,and blood loss was about 15ml. The patient was discharged on postoperative day 2, and the human chorionic gonadotropin level turned negative after 2 weeks. We describe a laparoscopic surgical treatment that does not require incision of myometrium, reduced the blood loss while preserved uterine integrity.
Effect of Intrauterine Perfusion of HCG-activated Autologous Human Peripheral Blood Mononuclear Cells on Pregnancy Outcomes in Frozen/thawed Embryo Transfer Cycles of Patients with Different BMIs: A Retrospective Study
Authors: Yang Zhe , Zhao Jing , Zhang Qixuan , Ou Xiangyang , Zhang Mengying , Zhang Yu , Wu Gengxiang 
Published: July 2024

Abstract

Background: In recent years, human peripheral blood mononuclear cells (PBMCs) intrauterine perfusion therapy has been widely used prior to embryo transfer for in vitro fertilization (IVF) to improve implantation rates and pregnancy outcomes in patients. However, there are fewer studies on which groups of people are better able to change pregnancy outcomes with PBMCs. In the present study, we discussed the impact of intrauterine perfusion of PBMCs before thawed embryo transfer (FET) on pregnancy outcomes in patients with different BMIs and ages.
Method: This study retrospectively included 563 patients who received PBMCs uterine perfusion therapy at Reproductive Medical Centre, Renmin Hospital of Wuhan University from 2019 to 2021. Grouped according to different BMI and age, analyze whether these factors influence clinical outcomes in patients receiving PBMCs uterine perfusion.
Result: The results showed that the clinical pregnancy and miscarriage rates were significantly higher in the high BMI group than in the normal BMI group (56.52% versus 44.09%, P=0.041). However, the higher rate of miscarriage in the high BMI group (13.04% versus 5.73%, P=0.037) made the difference in live birth rates not particularly significant (32.61% vs. 31.90%, P=?). This situation was significant in the young patients (age≤30ys), for patients who were advanced reproductive age, it was difficult to improve the clinical pregnancy rate by intrauterine administration of PBMCs.
Conclusion: Intrauterine perfusion of autologous PBMCs prior to transfer in patients undergoing FET modifies clinical pregnancy rates in patients with high BMI. This change is more pronounced in younger patients.
Impact of Regional Comprehensive Cardiovascular Disease Centers on Mortality in Korea
Authors: Jang Ye Seul , Kim Soo Young , Park Eun-Cheol 
Published: July 2024

Abstract

Cardiovascular disease (CVD) remains an important global contributor to mortality and morbidity, with South Korea experiencing higher fatality rates from acute CVD despite excellent hospital care. We investigated regional CVD centers in Korea’s impact on CVD-related mortality rates. This population-based cohort study obtained data from the 2002–2019 Korean National Health Insurance Service–National Sample Cohort. Eleven of the 15 regional CVD centers were included in the study. For the 2 years pre- and post-establishment of the regional CVD centers, 15,687 patients’ data were included in the study. The inclusion criteria included (1) having consulted at an emergency room (ER) with the principal diagnosis of acute CVD, including ischemic and hypertensive CVD, and (2) residing in the area where the regional CVD center was established during the study cohort period. Patients not meeting these criteria were excluded. The dependent variable, CVD-related mortality, included mortalities occurring within 30, 60, and 90 days of the first consultation at the ER. To analyze the time trend and its change in outcomes, an interrupted time-series analysis with segmented regression was performed. There were 8,009 and 7,678 patients in the pre- and post-intervention cohorts, respectively. The probability of death within 30 days after an ER (or regional CVD center) visit among patients with acute heart disease decreased following the designation of the regional CVD center in that area (estimate, 0.9570; 95% confidence interval, 0.9213–0.9942). The designation of regional CVD centers, as part of the government health policy, reduces the acute CVD-related 30-day mortality in patients who have consulted at the ER.
Altered functional connectivity within and between resting-state networks in ulcerative colitis
Authors: Ren Yanjun , Xue Kaizhong , Xu Huijuan , Hao Lijie , Zhao Quchuan , Chi Tianyu , Yang Hongwei , Zhao Xiaojing , Tian Defeng , Zhai Huihong , Lu Jie 
Published: July 2024

Abstract

Background
Patients with ulcerative colitis (UC) commonly present with affective disorders such as depression and anxiety, especially during the active phase of the disease. However, the possible neurological mechanisms of these symptoms remain unclear. The aim of this study was to investigate the alteration of functional connectivity (FC) within each resting-state network (RSN) and between RSNs in ulcerative colitis patients.
Methods
Twelve meaningful RSNs were identified from 22 ulcerative colitis patients and 23 healthy controls using independent component analysis (ICA) of functional magnetic resonance imaging data. Correlation analyses were performed between clinical indices, neuropsychological assessments and neuroimaging data.Results: Compared to healthy controls, UC patients showed increased intranetwork FC, mainly located in the right temporal pole, orbitofrontal cortex, and left superior temporal and Rolandic opercular cortices within the auditory network. In addition, UC patients showed increased connectivity between the dorsal attention and the left frontoparietal network, as well as between the anterior default mode network and the posterior default mode network. No significant correlations were found between altered brain regions and psychological scales in patients with UC.
Conclusions
These findings indicate that patients with UC may experience alterations at the level of the functional network. These alterations may impact not only the intranetwork FC within RSNs, but also the internetwork FC between these RSNs.
Cellulose Nanofiber Reinforced Curcumin-Infused Calcium Phosphate Silicate Cement: Material Characterization and Biocompatibility Assessment for Bone Cancer Defect Repair
Authors: Lu Guoxiu , Meng Lisha , Zhou Jingqiu , Wu Tao , Gong Tianxing , Wu Qiong 
Published: July 2024

Abstract

This study introduces a pioneering approach in bone tissue engineering for addressing defects caused by bone cancer, utilizing a novel injectable curcumin (Cur)-infused calcium phosphate silicate cement (CPSC). The research focuses on evaluating the dual functionality of CPSC-Cur: promoting bone regeneration and exerting cytotoxic effects on osteosarcoma cells. The material's physicochemical properties, biocompatibility with osteoblasts, and cytotoxicity towards osteosarcoma cells were rigorously analyzed. The findings demonstrate that CPSC-Cur significantly prolongs the setting time, which can be optimized by adding silanized cellulose nanofiber (CNF-SH) to achieve a balance between workability and mechanical strength. Biological assessments reveal a pronounced cytotoxic effect on osteosarcoma cells while maintaining minimal toxicity towards pre-osteoblasts, highlighting CPSC-Cur's potential as a promising material for repairing bone defects following cancer removal. This study lays the groundwork for future investigations into CPSC-Cur's in vivo efficacy and its role in the clinical treatment of bone cancer-related defects.
Selecting hazard-consistent ground motions for seismic risk analysis: an equivalent earthquake-based methodology
Authors: Li Bo 
Published: July 2024

Abstract

Seismic risk analysis has received significant attention from both academia and industry in recent years. When conducting seismic risk analyses, selecting hazard-consistent ground motions is crucial. Traditional methods for selecting hazard-consistent ground motions often have limitations, addressing only a few periods and using discrete intensity levels, which can lead to inaccurate risk estimates. This study introduces a novel methodology that overcomes these limitations by using equivalent earthquakes derived from special seismic hazard disaggregation. This approach generates a scenario earthquake set to simulate target response spectra consistent with the seismic hazards of a target site through importance sampling. A selection scheme is also proposed to identify hazard-consistent ground motions from a database. Furthermore, a new method for performing probabilistic seismic demand analysis is presented. A numerical example demonstrates that the selected ground motions maintain strong consistency with the site's seismic hazard curves across a wide range of periods. Unlike traditional methods, this approach does not depend on the fundamental period of specific buildings, making the selected ground motions applicable for accurate seismic risk analysis of multiple structures at the same site.
The energy dissipation process and dilation evolution of the rock subjected to incremental cyclic loading and unloading
Authors: Wang Bin , Zhu Jiebing , Xu Dongdong , Zhu Yujie 
Published: July 2024

Abstract

Rock mass around underground engineering is sometimes subjected to varying degrees of cyclic load, such as geological tectonic movements, seismic events, excavation, and support of underground caves, which induces some certain deterioration for rock mass strength due to energy dissipation and cumulative micro fractures. Some key scientific questions include the mechanism of energy dissipation and the law of strength parameters' evolution of rock subjected to cyclic increasing loading. In order to clarify the relations between rock energy dissipation and the dilation evolution during the process of failure, an incremental cyclic loading mode is proposed and adopted in uniaxial and triaxial tests. First, the dilation test method and procedure are proposed in this article to improve the test success rate. Granite gneiss specimens sampled from the Southern Xinjiang region were tested to obtain the mineral composition's fundamental mechanical parameters. The incremental cyclic loading uniaxial and triaxial tests are carried out under confining pressure from 0 MPa to 50 MPa during pre-peaking and post-peaking strength periods. From the viewpoint of energy dissipation, the damage variable is defined, and its relationships with the energy dissipation parameters and principal strain(residual strain and residual shear strain) are deeply analyzed during cyclic loading. Moreover, the confining pressure effect on the energy parameters and variables was studied as well. For each cyclic loading and unloading, the relationship between residual volumetric strains versus residual principal strains was acquired from the curves, which provides the fundamental data for further dilation property research. According to the evolution law of damage variable versus plastic shear strain curves, the relationships between energy dissipation ratio and shear dilation angle are constructed. In summary, the research reveals that the damage evolution process of rock is based on the energy dissipation mechanism, and these relationships with its dilation to failure show important significance, which sets up a bridge between the energy mechanism and dilation during the failure process.
Analysis of associated factors affecting hematoma evacuation rates in spontaneous intracerebral hemorrhage with stereotactic aspiration combined with catheter drainage
Authors: Luo Xinqun , Song Keming , Zhuo Lingyun , Lin Fuxin , Gao Zhuyu , He Qiu , Zheng Yan , Lian Kunbin , Shangguan Huangcheng , Lin Yuanxiang , Kang Dezhi , Fang Wenhua 
Published: July 2024

Abstract

The aim of this study was to delve into the relevant factors affecting hematoma evacuation (HE) rates during the treatment of sICH with stereotactic aspiration combined with catheter drainage. We pooled individual data from our prospective ICH databas, encompassing patients who underwent stereotactic aspiration and catheter drainage between July 2019 and July 2023. The primary outcome was HE rates prior to extubation, the secondary outcome was HE rates within 24 hours postoperatively. Logistic regression was employed to assess relevant clinical and radiological characteristics to establish a predictive model for achieving HE rates ≥ 70%. The model was validated by the ROC curve. Of the 894 patients with sICH enrolled in our database, 106 were eligible for this analysis. Factors affecting HE on the initial postoperative day were determined as preoperative hematoma volume (OR, 0.913; 95% CI, 0.836-0.997; P=0.042), blend sign (OR, 9.457; 95% CI, 0.999-89.508; P=0.050), and the catheter position score (OR, 5.551; 95% CI, 1.231-25.019; P=0.026). The positive blend sign (OR, 4.120; 95% CI, 1.344-12.630; P=0.013), absence of irregular hematoma morphology (OR, 0.291; 95% CI, 0.095-0.893; P=0.031), and hematoma edge not linked to the ventricle (OR, 0.185; 95% CI, 0.036-0.950; P=0.043) emerged as independent predictors for achieving HE rates ≥ 70% prior to extubation. Then, we developed two predictive models: one for early HE rates≥ 70%with a score from 0 to 7, and another for prior to extubation, scoring from 0 to 3. The ROC curve revealed AUC values of 0.871 and 0.753 for each model, respectively, and cutoff values of 5.5 and 1.5, accordingly. The predictive model of HE rates ≥ 70% within 24 hours postoperatively and prior to extuation has demonstrated remarkable predictive capability, holds the potential to assist clinicians in optimizing surgical efficiency.
Trial registration
ClinicalTrials.gov Identifier NCT03862729.
Low-Cost Male Urogenital Simulator for Penile Implant Surgery Training:A 3D Printing Approach
Authors: Wang Zixi , Saija Carlo , Raison Nicholas , Aydin Abdullatif , Xu Zhouyang , Zuo Katie , Rhode Kawal , Pontiki Antonia 
Published: July 2024

Abstract

Background
Penile implant surgery is the standard surgical treatment for end-stage erectile dysfunction. However, the growing complexity of modern high-tech penile prostheses has increased the demand for more practical training opportunities. The most advanced contemporary training methods involve simulation training using cadavers, with costs exceeding $5,000 per cadaver, inclusive of biohazard fees. This study introduces an innovative and cost-efficient male urogenital simulator designed to enhance penile implant surgery training.
Methods
Utilizing image segmentation of patient pre-operative computed tomography (CT) scans, combined with three-dimensional (3D) printing and silicone molding techniques, we developed a high-fidelity simulator replicating the anatomical structures of the male urogenital system. The simulator incorporates an innovative double-layer structural design encompassing the corpus spongiosum and glans, corpora cavernosa, testes, epididymides, and pelvic bones. Additionally, it utilizes a two-stage skin manufacturing process tailored for different skin regions. The simulator was produced at a low material cost of £10, with an average production time of 3 hours. To evaluate its training efficacy, we conducted a penile implant surgery training session involving 15 urology trainees and surgeons ranging from specialty training levels ST3 to ST6. The session began with a demonstration of penile implant surgery and error detection. Trainees, averaging three per simulator, practiced corporotomy, dilation, measurement, penile prosthesis, and scrotal pump placement under expert guidance. Participants' feedback was collected using a Likert scale questionnaire, assessing learning, satisfaction, and anatomical accuracy.
Results
Quantitative analysis of the questionnaire responses indicated highly positive feedback from the participants. Satisfaction rates surpassed 96% in learning effectiveness, over 89% in overall satisfaction, and 86% in anatomical accuracy demonstration. The simulator was favourably reviewed by both urology trainees and experienced surgeons, highlighting its utility as a practical training tool. Its low production cost and high precision make it a viable alternative to current training models.
Conclusions
The development of this cost-efficient, anatomically accurate urogenital simulator through advanced imaging and additive manufacturing techniques represents a significant advancement in penile implant surgical training. This state-of-the-art simulator not only provides a realistic and practical training experience but also underscores the potential for 3D printing technologies to revolutionize medical education and training.
Strategic Safeguarding: A Game Theoretic Approach for Analyzing Attacker-Defender Behavior in DNN Backdoors
Authors: Kallas Kassem , Roux Quentin Le , Hamidouche Wassim , Furon Teddy 
Published: July 2024

Abstract

Deep neural networks (DNNs) are fundamental to modern applications like face recognition and autonomous driving. However, their security is a significant concern due to various integrity risks, such as backdoor attacks. In these attacks, compromised training data introduce malicious behaviors into the DNN, which can be exploited during inference or deployment. This paper presents a novel game-theoretic approach to model the interactions between an attacker and a defender in the context of a DNN backdoor attack.
The contribution of this approach is multifaceted. First, it models the interaction between the attacker and the defender using a game-theoretic framework. Second, it designs a utility function that captures the objectives of both parties, integrating clean data accuracy and attack success rate. Third, it reduces the game model to a two-player zero-sum game, allowing for the identification of Nash equilibrium points through linear programming and a thorough analysis of equilibrium strategies. Additionally, the framework provides varying levels of flexibility regarding the control afforded to each player, thereby representing a range of real-world scenarios.
Through extensive numerical simulations, the paper demonstrates the validity of the proposed framework and identifies insightful equilibrium points that guide both players in following their optimal strategies under different assumptions. The results indicate that fully using attack or defense capabilities is not always the optimal strategy for either party. Instead, attackers must balance inducing errors and minimizing the information conveyed to the defender, while defenders should focus on minimizing attack risks while preserving benign sample performance. These findings underscore the effectiveness and versatility of the proposed approach, showcasing optimal strategies across different game scenarios and highlighting its potential to enhance DNN security against backdoor attacks.
Synthesis and Characterization of New Organometallic Lanthanides Metal Complex with Promising Photo Physical Activities
Authors: Batouti mervette El , El-Mossalamy E. H. , Desouky J. M. El , Fetouh Howida 
Published: July 2024

Abstract

New Schiff base ligand 4-methoxy salicaldhyde (3-hydrazonobutan-2-one) has been prepared. Molecular structures is characterized by elemental analysis, melting point.1H-NMR spectra (3.5 ppm-10.39ppm) confirmed protons and 13C-NMR confirmed carbons. New optically active metal complexes of Sm(III), Gd(III) and Tb(III) Schiff were synthesized in one pot reaction. Vibrational IR bands confirmed multifunctional groups. Scanning electron microscopy (SEM) micrographs confirmed microstructure of metal complexes. Good optically activity of solid complexes are confirmed from electronic absorption spectra. X-ray diffraction patterns confirmed good crystalline structure of the metal complexes. Large absorption wavelength λmax.280–390 nm and intense phosphorescence bands up to 730 nm of metal complex enabled application in photo dynamic therapy for cancer cells by enhancing cell apoptosis. Metal complexes act by conversion oxygen in tissue into reactive singlet oxygen that destroy cancer cell. Low charge transfer energy: 2.59 eV-2.61 eV and high molar extinction coefficients ε 6×104 M-1cm-1 reflected good optical activity.
M&amp;M3D: Multi-Dataset Training and EfficientNetwork for Multi-view 3D Object Detection
Authors: Zhang Hang 
Published: July 2024

Abstract

The research focuses on the challenge of domain adaptation and visual data transfer in camera-only 3D object detection. Despite numerous advancements in borderline methods, their performance significantly decreases across domains. 'M\&M3D' is introduced as a novel training approach for multi-view 3D object detection utilizing exclusively camera data under the multi-dataset training. 'M\&M3D' leverages 2D multi-view image features, 3D anchor queries and 3D space information as positional information and relies on a modest amount of source data as the visual-language transfer design. 'M\&M3D' exhibits favorable performance on standard metrics of 3D object detection with a smaller network size, distinguishing itself from dataset-specific models that require longer training time and individual fine-tuning on source domain. It might ignite future deployment of models on smaller devices.
Expanding housekeeping gene concepts: The role of retroelements in gene expression stability across tissues
Authors: Park Hyeon-Chun , Choi Haeyoun , Kim Sukil , Choi Jinyong , Oh Jung-Hwan , Rhyu Mun-Gan , Hong Seung-Jin 
Published: July 2024

Abstract

Background
Housekeeping genes (HKGs), essential for cellular differentiation, are traditionally thought to be uniformly expressed. However, recent analyses revealed variable expression of most genes across tissues, challenging this view. Identifying HKGs based on stable expression necessitates precise, repeated experiments. The limited number of transcription factors during differentiation implies that HKGs stabilise phenotypes through compensatory gene regulation.
Methods
We investigated the influence of retroelements, which constitute approximately 40% of the human genome, on gene expression stability based on proximity to transcriptional start sites (TSSs). By mapping CpG islands and retroelements within 10 kb of TSSs, we analysed 56 RNA sequencing datasets.
Results
CpG-island genes near Alu elements exhibited low expression variability, especially when the Alu elements were closer to the TSSs. Conversely, non-CpG island genes near L1 and LTR elements showed high variability, indicating distinct regulatory roles. Despite the constant number of Alu-adjacent CpG-island genes across tissues, their expression was the strongest in embryonic stem cells and declined in most differentiated tissues, except for an increase in the ovary and testis.
Conclusions
Alu elements near CpG islands help stabilise phenotypes through compensatory downregulation of HKGs. These findings support the expansion of the HKG concept to include genes maintaining stable phenotypes during tissue differentiation, aiding in differentiation stage identification.