bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of Particulate Emissions From Thermal Runaway of Lithium-Ion Cells
Authors: Premnath Vinay , Parhizi Mohammad , Niemiec Nicholas , Smith Ian , Jeevarajan Judith 
Published: July 2024

Abstract
Over the past decade, there has been a significant acceleration in the adoption of lithium-ion (Li-ion) batteries for various applications, ranging from portable electronics to automotive, defense, and aerospace applications. Lithium-ion batteries are the most used energy storage technologies due to their high energy densities and capacities. However, this battery technology is a potential safety hazard under off-nominal conditions, which may result in thermal runaway events. Such events can release toxic gaseous and particulate emissions, posing a severe risk to human health and the environment. Particulate emissions from the failure of two different cell chemistries—lithium iron phosphate (LFP) and nickel manganese cobalt oxide (NMC)—were studied. Experiments were conducted at multiple states of charge (SOC), and three repeats were performed at each SOC for each cell chemistry to examine the repeatability/variability of these events. Particulate emissions were characterized in terms of particulate matter mass (PM2.5), black carbon, and particle number (PN)/size. Failure of a single cell led to a significant release of particulate emissions, with peak emission levels being higher at the higher SOCs. A high level of variability was observed for a specific SOC for LFP cells, while NMCs exhibited relatively less variability. In general, much higher particulate emissions were observed for NMCs compared to LFPs at each SOC. For NMCs at 100% SOC, peak PN levels were ∼2.5 × 10+09 particles/cc (part/cc), and black carbon levels were ∼60 mg/m3. For LFPs at 100% SOC, peak PN levels were ∼9.0 × 10+08 part/cc, and black carbon levels were 2.5 mg/m3.
Cefiderocol heteroresistance associated with mutations in TonB-dependent receptor genes in
Pseudomonas aeruginosa
of clinical origin
Authors: Egge Stephanie L. , Rizvi Samie A. , Simar Shelby R. , Alcalde Manuel , Martinez Jose R. W. , Hanson Blake M. , Dinh An Q. , Baptista Rodrigo P. , Tran Truc T. , Shelburne Samuel A. , Munita Jose M. , Arias Cesar A. , Hakki Morgan , Miller William R. 
Published: July 2024

ABSTRACT

The siderophore-cephalosporin cefiderocol (FDC) presents a promising treatment option for carbapenem-resistant (CR)
P. aeruginosa
(PA). FDC circumvents traditional porin and efflux-mediated resistance by utilizing TonB-dependent receptors (TBDRs) to access the periplasmic space. Emerging FDC resistance has been associated with loss of function mutations within TBDR genes or the regulatory genes controlling TBDR expression. Further, difficulties with antimicrobial susceptibility testing (AST) and unexpected negative clinical treatment outcomes have prompted concerns for heteroresistance, where a single lineage isolate contains resistant subpopulations not detectable by standard AST. This study aimed to evaluate the prevalence of TBDR mutations among clinical isolates of
P. aeruginosa
and the phenotypic effect on FDC susceptibility and heteroresistance. We evaluated the sequence of
pirR
,
pirS
,
pirA
,
piuA
, or
piuD
from 498 unique isolates collected before the introduction of FDC from four clinical sites in Portland, OR (1), Houston, TX (2), and Santiago, Chile (1). At some clinical sites, TBDR mutations were seen in up to 25% of isolates, and insertion, deletion, or frameshift mutations were predicted to impair protein function were seen in 3% of all isolates (
n
= 15). Using population analysis profile testing, we found that
P. aeruginosa
with major TBDR mutations were enriched for a heteroresistant phenotype and undergo a shift in the susceptibility distribution of the population as compared to susceptible strains with wild-type TBDR genes. Our results indicate that mutations in TBDR genes predate the clinical introduction of FDC, and these mutations may predispose to the emergence of FDC resistance.
Discovery of new antigens for serodiagnosis of visceral leishmaniasis in humans and dogs adds valuable tools to our arsenal
Authors: Iniguez Eva , Kamhawi Shaden 
Published: July 2024

ABSTRACT

Surveillance and sustained control of visceral leishmaniasis (VL) require reliable serodiagnostic tools. rK39, the gold standard antigen for VL diagnosis, is limited by its documented poor sensitivity in certain endemic regions, such as East Africa, and by the longevity of its antibodies, making it difficult to distinguish active from cured infections. In a recent publication in
mBio
, Roberts et al. (A. J. Roberts, H.B. Ong, S. Clare, C. Brandt, et al., mBio 15:e00859-24, 2024,
https://doi.org/10.1128/mbio.00859-24
) identified new immunogenic
Leishmania
candidates in dogs and humans. In dogs, combined antigens LdBPK_290790.1 + LdBPK_362700.1 (D4 +D46) distinguished symptomatic from asymptomatic infections. For humans, LdBPK_323600.1 (D36) antigen produced short-lived antibodies and performed well in patient cohorts from Bangladesh and Ethiopia, but not Kenya. This study adds promising new candidates to our serodiagnostic toolbox but highlights the need for more antigen discovery studies that may have to be focused on regional performance.
P–T evolution of metapelitic and metamafic rocks from Northern Liaoning: Implications on the Neoarchean tectonic regime of the North China Craton
Authors: Guo Minjie , Zhang Jian , Qian Jiahui , Yin Changqing , Gao Peng , Chen Guokai , Cheng Changquan , Hsia Juiyen , Zhang Shuhui 
Published: July 2024

Abstract
The Archean basement rocks in the Eastern Block of the North China Craton have undergone extensive granulite-facies metamorphism during the late Neoarchean to Paleoproterozoic. However, the geodynamic process and associated tectonic regime of this area remain poorly understood. The Qingyuan area of Northern Liaoning, located in the nucleus of the Eastern Block, plays a crucial role in unraveling the tectonothermal evolution by reconstructing its metamorphic history. Previous studies have mainly focused on the northern part of the area, while the tectonothermal evolution of the southern part remains unknown. In this study, we utilized petrography, phase equilibria modeling, and geochronology to constrain the pressure–temperature–time (P–T–t) paths of representative metapelite and metabasite samples of the area. Our results indicate that both samples have recorded anticlockwise P–T–t paths. The peak condition for the metapelitic rock sample 22QY02-9 is 10.0–11.2 kbar/800–815 °C. U-Pb zircon and monazite dating results indicate a post-peak metamorphic age of ca. 2470–2450 Ma. Metamafic rock sample 22QY04-3 reaches the ultrahigh temperature peak metamorphic condition of 11.5–12.5 kbar/920–950 °C, which is consistent with the results obtained from the ternary-feldspar thermometry calculations. U-Pb zircon dating reveals a cooling age of metamorphism at ca. 2487 Ma. By combining the data from this study with previous research, a sagduction model, operating under a non–plate tectonics regime, appears to be the most promising explanation for the most prevalent geological phenomena in the Neoarchean North China Craton.
Fitness-related physical activity intensity explains most of the association between accelerometer data and cardiometabolic health in persons 50–64 years old
Authors: Fridolfsson Jonatan , Ekblom-Bak Elin , Ekblom Örjan , Bergström Göran , Arvidsson Daniel , Börjesson Mats 
Published: July 2024

Objectives
To investigate the physical activity (PA) intensity associated with cardiometabolic health when considering the mediating role of cardiorespiratory fitness (CRF).

Methods
A subsample of males and females aged 50–64 years from the cross-sectional Swedish CArdioPulmonary bioImage Study was investigated. PA was measured by accelerometry and CRF by a submaximal cycle test. Cardiometabolic risk factors, including waist circumference, systolic blood pressure, high-density lipoprotein, triglycerides and glycated haemoglobin, were combined to a composite score. A mediation model by partial least squares structural equation modelling was used to analyse the role of CRF in the association between PA and the composite score.

Results
The cohort included 4185 persons (51.9% female) with a mean age of 57.2 years. CRF mediated 82% of the association between PA and the composite score. The analysis of PA patterns revealed that moderate intensity PA explained most of the variation in the composite score, while vigorous intensity PA explained most of the variation in CRF. When including both PA and CRF as predictors of the composite score, the importance of vigorous intensity increased.

Conclusion
The highly interconnected role of CRF in the association between PA and cardiometabolic health suggests limited direct effects of PA on cardiometabolic health beyond its impact on CRF. The findings highlight the importance of sufficient PA intensity for the association with CRF, which in turn is linked to better cardiometabolic health.
Synergistic effects of social determinants of health and race-ethnicity on 30-day all-cause readmission disparities: a retrospective cohort study
Authors: Su Wan-Ting K , Cannella Cara , Haeusler Jessica , Adrianto Indra , Rubinfeld Ilan , Levin Albert M 
Published: July 2024

ObjectiveThe objective of this study is to assess the effects of social determinants of health (SDOH) and race-ethnicity on readmission and to investigate the potential for geospatial clustering of patients with a greater burden of SDOH that could lead to a higher risk of readmission.DesignA retrospective study of inpatients at five hospitals within Henry Ford Health (HFH) in Detroit, Michigan from November 2015 to December 2018 was conducted.SettingThis study used an adult inpatient registry created based on HFH electronic health record data as the data source. A subset of the data elements in the registry was collected for data analyses that included readmission index, race-ethnicity, six SDOH variables and demographics and clinical-related variables.ParticipantsThe cohort was composed of 248 810 admission patient encounters with 156 353 unique adult patients between the study time period. Encounters were excluded if they did not qualify as an index admission for all payors based on the Centers for Medicare and Medicaid Service definition.Main outcome measureThe primary outcome was 30-day all-cause readmission. This binary index was identified based on HFH internal data supplemented by external validated readmission data from the Michigan Health Information Network.ResultsRace-ethnicity and all SDOH were significantly associated with readmission. The effect of depression on readmission was dependent on race-ethnicity, with Hispanic patients having the strongest effect in comparison to either African Americans or non-Hispanic whites. Spatial analysis identified ZIP codes in the City of Detroit, Michigan, as over-represented for individuals with multiple SDOH.ConclusionsThere is a complex relationship between SDOH and race-ethnicity that must be taken into consideration when providing healthcare services. Insights from this study, which pinpoint the most vulnerable patients, could be leveraged to further improve existing models to predict risk of 30-day readmission for individuals in future work.
Infection in preterm infants receiving topical emollient oil massage: a systematic review and meta-analysis of randomised control trials
Authors: Getaneh Fekadeselassie Belege , Asmare Aden , Abayneh Bezabih , Birre Endalk , Mohammed Anissa , Muche Amare , Gedefie Alemu , Asmamaw Yibeltal , Mengesha Zemen , Moges Natnael , Birhanu Dires Mihretie , Bitew Zebenay Workneh , Molla Asressie 
Published: July 2024

BackgroundPreterm infants are highly susceptible to infections, which significantly contribute to morbidity and mortality. This systematic review and meta-analysis investigated the effectiveness of topical emollient oil application in preventing infections among preterm infants.MethodsA comprehensive search was conducted across multiple electronic databases (PubMed, Cochrane, Scopus, Clinical trials, Epistemonikos, HINARI and Global Index Medicus) and other sources. A total of 2185 articles were identified and screened for eligibility. The quality of included studies was assessed using the Cochrane Risk of Bias Tool for randomised controlled trials. Data analysis was performed using StataCrop MP V.17 software. Heterogeneity among the studies was evaluated using the I2and Cochrane Q test statistics. Sensitivity and subgroup analyses were conducted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses checklist guided the presentation of the results.ResultsOf 2185 retrieved articles from initial searches, 11 met eligibility criteria and were included in the final analysis. A random effects meta-analysis revealed that infants who received massages with emollient oils had a 21% reduced risk of infection (risk ratio=0.79, 95% CI 0.64 to 0.97, I2=0.00%). Subgroup analyses indicated that preterm babies who received topical emollient oil massages with coconut oil, administered twice a day for more than 2 weeks, had a lower likelihood of acquiring an infection compared with their non-massaged counterparts.ConclusionIt is quite evident from this analysis that topical emollient oil application in preterm neonates is most likely effective in preventing infection. However, further studies, particularly from the African continent, are warranted to support universal recommendations.
Cumulative sucrose exposure for repeated procedural pain in preterm neonates and neurodevelopment at 18 months of corrected age: a prospective observational longitudinal study
Authors: Bueno Mariana , Ballantyne Marilyn , Campbell-Yeo Marsha , Estabrooks Carole , Gibbins Sharyn , Harrison Denise , McNair Carol , Riahi Shirine , Squires Janet , Synnes Anne R , Taddio Anna , Victor Charles , Yamada Janet , Stevens Bonnie 
Published: July 2024

IntroductionOral sucrose is repeatedly administered to neonates in the neonatal intensive care unit (NICU) to treat pain from commonly performed procedures; however, there is limited evidence on its long-term cumulative effect on neurodevelopment. We examined the association between total sucrose volumes administered to preterm neonates for pain mitigation in the NICU and their neurodevelopment at 18 months of corrected age (CA).MethodsA prospective longitudinal single-arm observational study that enrolled hospitalised preterm neonates <32 weeks of gestational age at birth and <10 days of life was conducted in four level III NICUs in Canada. Neonates received 0.1 mL of 24% sucrose 2 min prior to all commonly performed painful procedures during their NICU stay. Neurodevelopment was assessed at 18 months of CA using the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III). Multiple neonatal and maternal factors known to affect development were adjusted for in the generalised linear model analysis.Results172 preterm neonates were enrolled and 118 were included in the analysis at 18 months of CA. The total mean sucrose volume administered/neonate/NICU stay was 5.96 (±5.6) mL, and the mean Bayley-III composite scores were: cognitive 91 (±17), language 86 (±18) and motor 88 (±18). There was no association between Bayley-III scores and the total sucrose volume: cognitive (p=0.57), language (p=0.42) and motor (p=0.70).ConclusionCumulative sucrose exposure for repeated procedural pain in preterm neonates was neither associated with a delay in neurodevelopment nor neuroprotective effects at 18 months of CA. If sucrose is used, we suggest the minimally effective dose combined with other non-pharmacological interventions with demonstrated effectiveness such as skin-to-skin contact, non-nutritive sucking, facilitated tucking and swaddling.Trial registration numberNCT02725814.
DYNAMIC VOLATILITY SPILLOVERS BETWEEN CURRENCIES OF ASEAN MEMBER COUNTRIES AND CHINA: EVIDENCE FROM TVP-VAR APPROACH
Authors: LIU MIN , LIU HONG-FEI , LIU SHUAI 
Published: July 2024

Driven by the importance of analyzing interregional volatility spillover effects, this study investigates dynamic volatility spillovers between the currencies of China– ASEAN Free Trade Area (FTA) member countries by applying the time-varying parameter vector autoregressive (TVP-VAR) connectedness approach to a sample spanning January 1, 2006, to October 31, 2022. The results show that (1) dynamic volatility connectedness varies over time and reaches peaks due to economic events, such as the 2008 global financial crisis (GFC) and the COVID-19 pandemic; (2) the Chinese yuan (CNY) market assumes more of a net receiving role for volatility spillovers after the 811 exchange rate reform, while the Singapore dollar (SGD) market assumes more of a net transmitting role for volatility spillovers in the whole sample period and (3) negative spillovers are dominant during the study period, except during the European debt crisis. Our findings can help China and ASEAN establish an exchange rate coordination mechanism to prevent the cross-country transmission of exchange rate risk.
Convenient and Accurate Detection of Dopamine and Glucose by Modifying Carbon Fiber Electrodes
Authors: Han Fengjin , Zhang Xiaoyan , Li Zijin , Sun Haowei , Yuan Hua , Huang Xiaoyu 
Published: July 2024

Fast, sensitive, and low-cost high-performance detectors have gradually become an indispensable tool for people to keep healthy, and sensors are the key devices of detection equipment. In this work, a ZnO nanocrystal modified carbon fiber electrode was prepared using a hydrothermal method, and on this basis, a galvanostatic point deposition method was used to load copper nanoparticles to prepare a sensor electrode. Scanning electron microscopy and X-ray diffraction were used to comprehensively analyze composition, morphology, and environmental adaptability of the prepared electrodes. The DPV test was used to verify the enhanced effect of ZnO nanorods on neurotransmitter detection. The ZnO/CF showed an obvious electrical signal (0.22 V, 4 × 10−5A) in the detection of dopamine (DA) solution, and the Cu-NPs/ZnO/CF also showed excellent detection results in the glucose detection experiment., providing two excellent examples for the development of low-cost electrochemical sensors. The electrodes can specifically detect DA in the presence of ascorbic acid and uric acid, and the detection limit of the electrode for detecting DA is about 0.4 μM. In addition, the Cu-NPs/ZnO/CF electrode successfully realized the enzyme-free detection of glucose, and the detection limit could reach 0.5 μM.
CSF1R Inhibition in Patients with Advanced Solid Tumors or Tenosynovial Giant Cell Tumor: A Phase I Study of Vimseltinib
Authors: Gelderblom Hans , Razak Albiruni A. , Taylor Matthew H. , Bauer Todd M. , Wilky Breelyn , Martin-Broto Javier , Gonzalez Alejandro F. , Rutkowski Piotr , Szostakowski Bartlomiej , Alcindor Thierry , Saleh Ramy , Genta Sofia , Stacchiotti Silvia , van de Sande Michiel , Wagner Andrew J. , Bernthal Nicholas , Davis Lara E. , Vuky Jacqueline , Tait Christopher , Matin Bahar , Narasimhan Supraja , Sharma Maitreyi G. , Ruiz-Soto Rodrigo , Sherman Matthew L. , Tap William D. 
Published: July 2024

Abstract

Purpose:
Tenosynovial giant cell tumor (TGCT) is a locally aggressive neoplasm caused by dysregulation of the colony-stimulating factor 1 (CSF1) gene and overexpression of the CSF1 ligand. Surgery is the standard of care for most patients, but there are limited treatment options for patients with TGCT not amenable to surgery. This study evaluates vimseltinib, an investigational, oral, switch-control tyrosine kinase inhibitor designed to selectively and potently inhibit the CSF1 receptor.

Patients and Methods:
This first-in-human, multicenter, open-label phase I/II study of vimseltinib in patients with malignant solid tumors (N = 37) or TGCT not amenable to surgery (N = 32) followed a pharmacologically guided 3 + 3 study design (NCT03069469). The primary objectives were to assess safety and tolerability, determine the recommended phase II dose, and characterize the pharmacokinetics; exploratory objectives included pharmacodynamics and efficacy.

Results:
Vimseltinib was well tolerated; the majority of non-laboratory treatment-emergent adverse events were of grade 1/2 severity. There was no evidence of cholestatic hepatotoxicity or drug-induced liver injury. The recommended phase II dose was determined to be 30 mg twice weekly (no loading dose), and vimseltinib plasma exposure increased with the dose. In patients with TGCT, the median treatment duration was 25.1 months (range, 0.7–46.9), and the objective response rate as assessed by independent radiological review using RECIST version 1.1 was 72%.

Conclusions:
Vimseltinib demonstrated long-term tolerability, manageable safety, dose-dependent exposure, and robust antitumor activity in patients with TGCT not amenable to surgery.
Eftilagimod Alpha (Soluble LAG3 Protein) Combined with Pembrolizumab as Second-Line Therapy for Patients with Metastatic Head and Neck Squamous Cell Carcinoma
Authors: Forster Martin , Brana Irene , Pousa Antonio L. , Doger Bernard , Roxburgh Patricia , Bajaj Pawan , Peguero Julio , Krebs Matthew , Carcereny Enric , Patel Grisma , Mueller Christian , Brignone Chrystelle , Triebel Frederic 
Published: July 2024

Abstract

Purpose:
Eftilagimod alpha (efti), a soluble LAG3 protein, activates antigen-presenting cells (APC) and downstream T cells. TACTI-002 (part C) evaluated whether combining efti with pembrolizumab led to strong antitumor responses in patients with second-line recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC) while demonstrating good tolerability.

Patients and Methods:
In this multinational phase II trial using Simon’s two-stage design, patients who were PD-L(1)-naïve with R/M HNSCC who had failed first-line platinum-based therapy, unselected for PD-L1, received intravenous pembrolizumab (200 mg, once every 2 weeks) combined with subcutaneous efti (30 mg once every 2 weeks for 24 weeks and once every 3 weeks thereafter). The primary endpoint was objective response rate per RECIST 1.1 modified for immune-based therapy by investigator assessment. Additional endpoints included duration of response, progression-free survival, overall survival, and tolerability. Pharmacodynamic effects (absolute lymphocyte count) and Th1 cytokine biomarkers (IFNγ/CXCL10)] were evaluated in liquid biopsies.

Results:
Between March 2019 and January 2021, 39 patients were enrolled; 37 were evaluated for response. All patients received prior chemotherapy, and 40.5% were pretreated with cetuximab; 53.1% of patients had PD-L1 combined positive score &lt;20. With a median follow-up of 38.8 months, the objective response rate was 29.7%, including 13.5% complete responders. The median duration of response was not reached. Rapid and sustained absolute lymphocyte count increase was observed in patients who had an objective response. Th1 biomarkers increased sustainably after first treatment. No unexpected safety signals were observed.

Conclusions:
Efti plus pembrolizumab was safe and showed encouraging antitumor activity and pharmacodynamic effects in patients with second-line head and neck squamous cell carcinoma (HNSCC), thus supporting further evaluation of this combination in earlier treatment lines.