bluuebunny/crossref_metadata_2025_split huggingface dataset:
SUBSTITUSI KONSENTRAT DENGAN AMPAS KEDELAI TERHADAP FCR (FEED CONVERSIO RATIO) DAN IOFC (INCOME OVER FEED COST) AYAM PEJANTAN
Authors: Abi Veronika Krisnawati , Kustyorini Tri Ida Wahyu , Krisnaningsih Aju Tjatur Nugroho 
Published: August 2024

Penelitian ini bertujuan untuk mengevaluasi nilai FCR dan IOFC ayam pejantan ketika konsentrat dalam ransum diganti dengan ampas kedelai. Pada penelitian ini menggunakan 30 ekor ayam pejantan, umur 30 hari, dan berat badan rata-rata 500 gram per ekor, ampas kedelai, dan konsentrat. Penelitian ini menggunakan eksperimen lapangan dengan tiga perlakuan dan lima ulangan dan diatur sesuai Rancangan Acak Lengkap (RAL). Perlakuan yang diterapkan adalah P0 (konsentrat 100 %), P1 (konsentrasi 90 % dan ampas kedelai 10%), dan P2 (konsentrat 80 % dan ampas kedelai 20%). Variabel yang diteliti dalam penelitian ini adalah nilai FCR dan IOFC. Analisis varians (ANOVA) dilakukan untuk menguji data, dan jika terdapat pengaruh perlakuan, dilanjutkan dengan uji BNT (Beda Nyata Terkecil). Hasil penelitian menunjukkan bahwa substitusi konsentrat dengan ampas kedelai menghasilkan pengaruh yang sangat signifikan (P<0,01) terhadap rasio konversi pakan (FCR) dan IOFC ayam jantan. Nilai FCR terbaik ditunjukkan perlakuan P1 (2,01). Nilai IOFC terbaik ditunjukkan perlakuan P1 (Rp 13.749,2). Disimpulkan bahwa substitusi 90% konsentrat dengan 10% ampas kedelai memberikan nilai terbaik untuk FCR dan IOFC.
Visualisasi Potensi Sektor Perekonomian Kota Kediri Menggunakan Metode Shiftshare
Authors: Nurfarida Ellya , Sukya Fadelis , Nugroho Benni Agung , Aullia Fikha Rizky 
Published: August 2024

Kota Kediri merupakan Kota berkembang dalam sektor industri, pariwisata, dan hiburan. Hal ini didukung dengan adanya pembangunan Bandara Dhaha Kediri, yang menyebabkan calon investor tertarik berinvestasi. Permasalahan muncul ketika usaha investor tersebut tidak diimbangi dengan ketersediaan data pendukung investasi oleh pemerintah Kota Kediri. Salah satu data pendukung investasi Kota Kediri adalah pengelompokan sektor unggulan dan non unggulan Kota Kediri. Dimana hingga saat ini data perkembangan sektor unggulan maupun non unggulan Kota Kediri hanya tersedia di Badan Pusat Statistik dan disajikan dalam bentuk tabel saja. Sehingga investor mengalami kesulitan dalam menganalisis perkembangan sektor bidikan. Website dalam bentuk visualisasi dari tahun ke tahun perlu dikembangkan guna menunjang investor dalam menilai tingkat keberhasilan usahanya. Pengembangan aplikasi yang dapat menampilkan sektor unggulan dan non unggulan berbasis web dalam bentuk grafik akan memudahkan investor dalam menganalisis sektor yang diminati. Pengembangan aplikasi website dengan menggunakan framework Laravel menghasilkan visualisasi dalam bentuk diagram batang pada data PDRB Jawa Timur dan Kota Kediri, dan visualisasi dalam bentuk kuadran untuk pengelompokan sektor menggunakan metode shiftshare.
Modifikasi Pemberian Tawas Berupa Larutan untuk Penurunan Kekeruhan Air di Desa Sungai Rangas Hambuku
Authors: Khair Abdul , Noraida Noraida 
Published: August 2024

As many as 89.3% of people in Sungai Rangas Hambuku Village still use river water for daily purposes. Turbidity measurements in 2021 amounted to 56 Nephelometric Turbidity Units (NTU) and in 2023 amounted to 53 NTU. This turbidity value has exceeded the maximum level allowed for water for hygiene and sanitation purposes of <3 NTU. Training on how to reduce the level of turbidity using alum has been provided in 2021, but the community has difficulty applying alum in a solid dosage form. The purpose of this activity is to train participants in administering alum to water taken from the river with modifications in the form of a solution preparation. The implementation method is pre-test, provision of training materials and demonstrations, post-test, and follow-up on the application of alum application to reduce water turbidity. Activity location in Sungai Rangas Village The duration of the activity is 6 months. The target number is 50 housewives. The results of the activity showed that participants had increased their knowledge from a score of 41 to 76 to 71 to 100, participants were able to carry out the practice of making a 2% alum solution preparation, participants were able to carry out the practice of reducing the level of water turbidity using alum solution preparation, and participants were able to apply the results of the training in their respective homes.
Predictive biomarkers of mortality in patients with severe COVID-19 hospitalized in intensive care unit
Authors: dos Santos Medeiros Sandrelli Meridiana de Fátima Ramos , Sousa Lino Bruna Maria Nepomuceno , Perez Vinícius Pietta , Sousa Eduardo Sérgio Soares , Campana Eloiza Helena , Miyajima Fábio , Carvalho-Silva Wlisses Henrique Veloso , Dejani Naiara Naiana , de Sousa Fernandes Matheus Santos , Yagin Fatma Hilal , Al-Hashem Fahaid , Elkholi Safaa M. , Alyami Hanan , Souto Fabrício Oliveira 
Published: August 2024

ObjectivesThis study was performed to identify predictive markers of worse outcomes in patients with severe COVID-19 in an intensive care unit.MethodsSixty patients with severe COVID-19, hospitalized in the Intensive Care Unit (ICU) between March and July 2021, were stratified into two groups according to the outcome survivors and non-survivors. After admission to the ICU, blood samples were collected directly for biomarker analysis. Routine hematological and biochemical biomarkers, as well as serum levels of cytokines, chemokines, and immunoglobulins, were investigated.ResultsLymphopenia, neutrophilia, and thrombocytopenia were more pronounced in non-surviving patients, while the levels of CRP, AST, creatinine, ferritin, AST, troponin I, urea, magnesium, and potassium were higher in the non-surviving group than the survival group. In addition, serum levels of IL-10, CCL2, CXCL9, and CXCL10 were significantly increased in patients who did not survive. These changes in the biomarkers evaluated were associated with increased mortality in patients with severe COVID-19.ConclusionThe present study confirmed and expanded the validity of laboratory biomarkers as indicators of mortality in severe COVID-19.
How low can you go? Exploring impact of drones on haul out behaviour of harbour - and grey seals
Authors: Stepien Emilie Nicoline , Khan Jibran , Galatius Anders , Teilmann Jonas 
Published: August 2024

IntroductionDrones, or Unmanned Aerial Vehicles (UAVs), have emerged as valuable tools for wildlife monitoring, offering potentially non-intrusive observations in challenging terrains like marine ecosystems. Despite their potential, widespread use is impeded by regulatory constraints, especially in protected areas. MethodsThis study aims to assess the impact of varying flight altitudes and flight approaches of two commercial drones on the behaviour of harbour seals (Phoca vitulina) and grey seals (Halichoerus grypus) and compare to existing findings for marine mammals. We conducted a comparative analysis of the response to flight altitude from 70 m gradually descending to 10 m and two different flight approaches between the DJI Phantom 4Pro and the Autel EVO II RTK drones in the Danish part of the Wadden Sea.ResultsWe found varying responses, where species-specific sensitivity and environmental conditions appeared to influence the behavioural reactions of the seals. Our results reveal that seal reactions to drones are complex and depend on several factors, such as flight altitude, drone model, received noise levels, approach, weather conditions, the animals’ annual cycle, and geographic location. DiscussionThe outcomes hold significance for refining regulatory policies governing drone flights in protected marine environments, balancing conservation efforts with technological advancements in wildlife monitoring and ensuring undisturbed observations of seals.
Longitudinal antinuclear antibody titers in systemic lupus erythematosus and other rheumatic diseases
Authors: Littlejohn Emily A. , Kong Lingxuan , Wang Lu , Somers Emily C. 
Published: August 2024

IntroductionAntinuclear antibodies (ANAs) are a key feature of systemic lupus erythematosus (SLE) and marker of subclinical autoimmunity. Little is known about longitudinal ANA titers in individuals from the general population or in predicting clinical disease course in persons with rheumatic diseases.MethodsWe performed an exploratory analysis from an academic health system between 1999 and 2020 to assess intra-individual variation in ANAs longitudinally in persons with SLE, other ANA-associated rheumatic diseases, and ANA+ controls without rheumatic disease.ResultsPersons with SLE had a higher odds of positive ANA compared to those with other ANA-associated rheumatic diseases [OR 2.10, 95% CI (1.82, 2.43)] controlling for time and demographics (age, sex, race, ethnicity). Compared to ANA+ controls, the ANA titer strength was significantly higher for both the ANA-associated rheumatic disease (0.33 log units higher) and SLE groups (0.42 log units higher) controlling for demographics and time (p &lt; 0.001 for both). Over time from the first positive ANA, titer strength significantly decreased for all three groups, with average monthly decreases ranging between 0.001 to 0.004 log titer units (p ≤ 0.001 for all).ConclusionBased on this analysis of electronic health data spanning two decades, ANA titers may be more dynamic than previously accepted in patients with SLE and ANA-associated rheumatic diseases, with average titers tending to be higher in early disease and decreasing over time.
Antimetastatic and antitumor activities of oncolytic NDV AMHA1 in a 3D culture model of breast cancer
Authors: Al-Shammari Ahmed Majeed , Salman Marwa Ibrahim 
Published: August 2024

IntroductionNewcastle disease virus (NDV) AMHA1 is capable of killing cancer cells by direct replication or induction of apoptosis alongside other pathways. In this study, we report the potent antimetastatic and anticancer activities of NDV AMHA1 in a 3D spheroid model of breast cancer metastasis.Methodswe used two breast cancer cell lines AMJ13 and MCF7 in our metastasis model system.ResultsFirst, we showed that NDV AMHA1 can infect and kill breast cancer cells in proliferating adherent cells and tumor spheroids using different virus doses and studying virus replication kinetics. We showed that NDV can infect and spread within the spheroids that represent metastasis before and after reattachment. Furthermore, we evaluated the ability of NDV to induce apoptosis in cancer spheroids and by virus tracking showed that NDV infection is essential for the elimination of these metastasis spheroids.DiscussionThe mechanism by which NDV induces cell killing in the metastasis model is the induction of caspase-3 and P21 and inhibition of Ki67 in cancer cells, but not in normal cells. In conclusion, these results indicate that NDV AMHA1 has the ability to kill breast cancer metastases in suspension or attached, and this is a novel finding of NDV AMHA1 being a possibly efficient therapy against human metastatic breast cancer.
Nonlinear analysis of neuronal firing modulated by sinusoidal stimulation at axons in rat hippocampus
Authors: Yuan Yue , Ye Xiangyu , Cui Jian , Zhang Junyang , Wang Zhaoxiang 
Published: August 2024

IntroductionElectrical stimulation of the brain has shown promising prospects in treating various brain diseases. Although biphasic pulse stimulation remains the predominant clinical approach, there has been increasing interest in exploring alternative stimulation waveforms, such as sinusoidal stimulation, to improve the effectiveness of brain stimulation and to expand its application to a wider range of brain disorders. Despite this growing attention, the effects of sinusoidal stimulation on neurons, especially on their nonlinear firing characteristics, remains unclear.MethodsTo address the question, 50 Hz sinusoidal stimulation was applied on Schaffer collaterals of the rat hippocampal CA1 region in vivo. Single unit activity of both pyramidal cells and interneurons in the downstream CA1 region was recorded and analyzed. Two fractal indexes, namely the Fano factor and Hurst exponent, were used to evaluate changes in the long-range correlations, a manifestation of nonlinear dynamics, in spike sequences of neuronal firing.ResultsThe results demonstrate that sinusoidal electrical stimulation increased the firing rates of both pyramidal cells and interneurons, as well as altered their firing to stimulation-related patterns. Importantly, the sinusoidal stimulation increased, rather than decreased the scaling exponents of both Fano factor and Hurst exponent, indicating an increase in the long-range correlations of both pyramidal cells and interneurons.DiscussionThe results firstly reported that periodic sinusoidal stimulation without long-range correlations can increase the long-range correlations of neurons in the downstream post-synaptic area. These results provide new nonlinear mechanisms of brain sinusoidal stimulation and facilitate the development of new stimulation modes.
Identification of symptomatic carotid artery plaque: a predictive model combining angiography with optical coherence tomography
Authors: Zhuo Jun , Wang Lin , Li Ruolin , Li Zhiyuan , Zhang Junhu , Xu Yunjian 
Published: August 2024

ObjectiveSymptomatic carotid artery disease is indicative of an elevated likelihood of experiencing a subsequent stroke, with the morphology of plaque and its specific features being closely linked to the risk of stroke occurrence. Our study based on the characteristics of carotid plaque assessed by optical coherence tomography (OCT), the plaque morphology evaluated by digital subtraction angiography (DSA) and clinical laboratory indicators were combined, develop a combined predictive model to identify symptomatic carotid plaque.MethodsPatients diagnosed with carotid atherosclerotic stenosis who underwent whole-brain DSA and OCT examination at the Affiliated Hospital of Jining Medical University from January 2021 to November 2023 were evaluated. Clinical features, as well as DSA and OCT plaque characteristics, were analyzed for differences between symptomatic and asymptomatic cohorts. An analysis of logistic regression was carried out to identify factors associated with the presence of symptomatic carotid plaque. A multivariate binary logistic regression equation was established with the odds ratio (OR) serving as the risk assessment parameter. The receiver operating characteristic curve was utilized to assess the combined predictive model and independent influencing factors.ResultsA total of 52 patients were included in the study (symptomatic: 44.2%, asymptomatic: 55.8%). Symptomatic carotid stenosis was significantly linked to four main factors: low-density lipoprotein-cholesterol &gt;3.36 mmol/L [OR, 6.400; 95% confidence interval (CI), 1.067–38.402; p = 0.042], irregular plaque (OR, 6.054; 95% CI, 1.016–36.083; p = 0.048), ruptured plaque (OR, 6.077; 95% CI, 1.046–35.298; p = 0.048), and thrombus (OR, 6.773; 95% CI, 1.194–38.433; p = 0.044). The combined predictive model generated using four indicators showed good discrimination (Area Under Curve, 0.924; 95% CI, 0.815–0. 979). The p value was &lt;0.05 with 78.26% sensitivity and 93.10% specificity.ConclusionOCT is valuable in evaluating the plaque characteristics of carotid atherosclerotic stenosis. The combined predictive model comprising low-density lipoprotein-cholesterol &gt;3.36 mmol/L, irregular plaque, ruptured plaque, and thrombus could help in the detection of symptomatic carotid plaque. Further research conducted on additional independent cohorts is necessary to confirm the clinical significance of the predictive model for symptomatic carotid plaque.
Comprehensive analysis of systemic, metabolic, and molecular changes following prospective change to low-carbohydrate diet in adults with type 2 diabetes mellitus in India
Authors: Bhandarkar Nikhil Suresh , Shetty K. Bhujang , Shetty Naren , Shetty Keerthy , Kiran Anupama , Pindipapanahalli Narendra , Shetty Rohit , Ghosh Arkasubhra 
Published: August 2024

PurposeSouth Asians, especially Indians, face higher diabetes-related risks despite lower body mass index (BMI) compared with the White population. Limited research connects low-carbohydrate high-fat (LCHF)/ketogenic diets to metabolic changes in this group. Systematic studies are needed to assess the long-term effects of the diet, such as ocular health.MethodIn this prospective, observational study, 465 candidates aged 25–75 years with type 2 diabetes included with institutional ethics approval. A total of 119 subjects were included in the final study assessment based on the availability of pathophysiological reports, tears, and blood samples collected at baseline, 3rd, and 6th months. Serum and tear samples were analyzed by an enzyme-linked lectinsorbent assay, to examine secreted soluble protein biomarkers, such as IL-1β (interleukin 1 Beta), IL-6 (interleukin 6), IL-10 (interleukin 10), IL-17A (interleukin 17A), MMP-9 (matrix metalloproteinase 9), ICAM-1 (intercellular adhesion molecule 1), VEGF-A (vascular endothelial growth factor A), and TNF-α (tumor necrosis factor-alpha). A Wilcoxon test was performed for paired samples. Spearman’s correlation was applied to test the strength and direction of the association between tear biomarkers and HbA1c. p-value of &lt; 0.05 was considered significant.ResultsAfter a 3- and 6-month LCHF intervention, fasting blood sugar decreased by 10% (Δ: −14 mg/dL; p &lt; 0.0001) and 7% (Δ: −8 mg/dL; p &lt; 0.0001), respectively. Glycated hemoglobin A1c levels decreased by 13% (Δ: −1%; p &lt; 0.0001) and 9% (Δ: −0.6%; p &lt; 0.0001). Triglycerides reduced by 22% (Δ: −27 mg/dL; p &lt; 0.0001) and 14% (Δ: −19 mg/dL; p &lt; 0.0001). Total cholesterol reduced by 5.4% (Δ: −10.5 mg/dL; p &lt; 0.003) and 4% (Δ: −7 mg/dL; p &lt; 0.03), while low-density lipoprotein decreased by 10% (Δ: −11.5 mg/dL; p &lt; 0.003) and 9% (Δ: −11 mg/dL; p &lt; 0.002). High-density lipoprotein increased by 11% (Δ: 5 mg/dL; p &lt; 0.0001) and 17% (Δ: 8 mg/dL; p &lt; 0.0001). At the first follow-up, tear proteins such as ICAM-1, IL-17A, and TNF-α decreased by 30% (Δ: −2,739 pg/mL; p &lt; 0.01), 22% (Δ: −4.5 pg/mL; p &lt; 0.02), and 34% (Δ: −0.9 pg/mL; p &lt; 0.002), respectively. At the second follow-up, IL-1β and TNF-α reduced by 41% (Δ: −2.4 pg/mL; p &lt; 0.05) and 34% (Δ: −0.67 pg/mL; p &lt; 0.02). Spearman’s correlation between HbA1c and tear analytes was not statistically significant.ConclusionThe LCHF diet reduces the risk of hyperglycemia and dyslipidemia. Changes in tear fluid protein profiles were observed, but identifying promising candidate biomarkers requires validation in a larger cohort.
The relationship between physical activity levels and serum vitamin D levels varies among children and adolescents in different age groups
Authors: Ouyang Shengrong , Li Qin , Liu Zhuo , Yin Yan 
Published: August 2024

ObjectiveThe objective of the present study was to explore the relationship between physical activity (PA) levels and serum vitamin D levels in children and adolescents of different ages and sexes.MethodsAll the data in this study were collected during two cycles (2011–2014) of the National Health and Nutrition Examination Survey (NHANES). Our study participants were aged ≥3 and &lt; 20 years and had valid data for all variables, including vitamin D intake, serum vitamin D levels, PA volume and intensity levels, amount of time spent outdoors, body mass index (BMI), sex, and race.ResultsA total of 3,312 participants were included in the study; 1,672 were boys (50.4%), and 1,640 were girls (49.6%). A total of 250 (7.5%) children were aged 3–5 years, 1,474 (44.5%) were aged 6–11 years, and 1,588 (47.9%) were aged 12–19 years. Both PA volume and intensity were positively related to serum vitamin D levels in the 6–11-year-old boys and girls (p &lt; 0.05 for both) and in the 12–19-year-old boys. No significant relationship between PA volume or intensity and serum vitamin D levels was detected in the 3–5-year-old group or in the 12–19-year-old girl group. The time spent outdoors and the BMI of the participants had mediating effects on the relationships of PA volume and intensity with serum vitamin D levels in boys and girls aged 6–11 years.ConclusionThe relationship between PA and vitamin D varies among children and adolescents of different sexes and ages, and the sun exposure level and BMI had mediating effects on the relationship between PA and the serum vitamin D level. The mechanism of the relationship between PA and increased serum vitamin D levels needs further in-depth research.
Association of dietary niacin intake with all-cause and cardiovascular mortality of adult patients with chronic kidney disease in the United States: results from NHANES 1999–2018
Authors: Zhang Chao , Cheng Qi , Yang Xinjun , Zhao Wei , Luo Kaifa , Qin Yunlong 
Published: August 2024

ObjectiveThe relationship between dietary niacin intake (DNI) and mortality rates among patients afflicted with chronic kidney disease (CKD) is a subject of debate. Utilizing data derived from the National Health and Nutrition Examination Survey (NHANES), this study adopts a retrospective cohort design with an aim to investigate the association in the American adult patients with CKD.MethodsA cohort study was conducted in the National Health and Nutrition Examination Survey (NHANES) between 2009 and 2018 that enrolled 6,191 CKD patients aged 20 years and above. We collected data on mortality through 31 December 2018. DNI was measured using a 24-h recall method. The relationship between DNI levels and mortality from all causes and cardiovascular causes was analyzed using weighted Cox proportional hazards models. The Kaplan–Meier (K-M) survival curve was plotted to illustrate these associations.ResultsFollowing a median monitoring period of 85 months, it was observed that 2,419 individuals (33.08%) succumbed to all causes, whereas cardiovascular-related deaths were recorded for 746 participants (10.45%). When controlling for confounders, an inverse relationship was established between DNI and mortality rates. Specifically, a marginal increase of 1 mg/day in DNI corresponded to a reduced Hazard Ratios (HRs) of 0.993 (0.987, 0.999; p = 0.027) for all-cause mortality and 0.980 (0.969, 0.991; p &lt; 0.001) for cardiovascular mortality. A further stratified analysis by quartiles of DNI, with the lowest quartile serving as the reference, revealed that the highest quartile was associated with HRs of 0.820 (0.697, 0.966) for all-cause mortality and 0.663 (0.465, 0.944) for cardiovascular mortality, both displaying a significant trend (p &lt; 0.001). However, a subdivision of CKD patients by age showed that the protective effects of higher DNI were only confined to individuals aged 60 years and above but not to those under 60 years of age.ConclusionA negative correlation between DNI and mortality due to all causes and cardiovascular issues among CKD patients aged 60 and above was revealed based on the datasets; however, this association was not observed in younger individuals under 60. Consequently, enhancing DNI might serve as a beneficial therapeutic strategy specifically for the older CKD demographic.