bluuebunny/crossref_metadata_2025_split huggingface dataset:
Neurorestorative Therapy of Stroke in Type 2 Diabetes Mellitus Rats Treated With Human Umbilical Cord Blood Cells
Authors: Yan Tao , Venkat Poornima , Chopp Michael , Zacharek Alex , Ning Ruizhuo , Cui Yisheng , Roberts Cynthia , Kuzmin-Nichols Nicole , Sanberg Cyndy Davis , Chen Jieli 
Published: August 2015

Background and Purpose—
Diabetes mellitus is a high-risk factor for ischemic stroke. Diabetic stroke patients suffer worse outcomes, poor long-term recovery, risk of recurrent strokes, and extensive vascular damage. We investigated the neurorestorative effects and the underlying mechanisms of stroke treatment with human umbilical cord blood cells (HUCBCs) in type 2 diabetes mellitus (T2DM) rats.

Methods—

Adult male T2DM rats were subjected to 2 hours of middle cerebral artery occlusion (MCAo). Three days after MCAo, rats were treated via tail-vein injection with (1) PBS and (2) HUCBCs (5×10
6
), n=10 per group.

Results—

HUCBC stroke treatment initiated 3 days after MCAo in T2DM rats did not significantly decrease blood–brain barrier leakage (
P
=0.1) and lesion volume (
P
=0.078), but significantly improved long-term functional outcome and decreased brain hemorrhage (
P
<0.05) when compared with the PBS-treated T2DM MCAo control group. HUCBC treatment significantly promoted white matter remodeling as indicated by increased expression of Bielschowsky silver (axons marker), Luxol fast blue (myelin marker), SMI-31 (neurofilament), and Synaptophysin in the ischemic border zone. HUCBC promoted vascular remodeling and significantly increased arterial and vascular density. HUCBC treatment of stroke in T2DM rats significantly increased M2 macrophage polarization (increased M2 macrophage, CD163and CD 206; decreased M1 macrophage, ED1 and inducible nitric oxide synthase expression) in the ischemic brain compared with PBS-treated T2DM MCAo controls (
P
<0.05). HUCBC also significantly decreased proinflammatory factors, that is, matrix metalloproteinase 9, receptor for advanced glycation end products and toll-like receptor 4 expression in the ischemic brain.

Conclusions—
HUCBC treatment initiated 3 days after stroke significantly increased white matter and vascular remodeling in the ischemic brain as well as decreased neuroinflammatory factor expression in the ischemic brain in T2DM rats and promoted M2 macrophage polarization. HUCBC reduction of neuroinflammation and increased vascular and white matter axonal remodeling may contribute to the HUCBC-induced beneficial effects in T2DM stroke rats.
Rosiglitazone Promotes White Matter Integrity and Long-Term Functional Recovery After Focal Cerebral Ischemia
Authors: Han Lijuan , Cai Wei , Mao Leilei , Liu Jia , Li Peiying , Leak Rehana K. , Xu Yun , Hu Xiaoming , Chen Jun 
Published: August 2015

Background and Purpose—
Oligodendrogenesis is essential for white matter repair after stroke. Although agonists of peroxisome proliferator–activated receptors γ confer neuroprotection in models of cerebral ischemia, it is not known whether this effect extends to white matter protection. This study tested the hypothesis that the peroxisome proliferator–activated receptors γ agonist rosiglitazone enhances oligodendrogenesis and improves long-term white matter integrity after ischemia/reperfusion.

Methods—

Male adult C57/BL6 mice (25–30 g) were subjected to 60-minute middle cerebral artery occlusion and reperfusion. Rosiglitazone (3 mg/kg) was injected intraperitoneally once daily for 14 days beginning 2 hours after reperfusion. Sensorimotor and cognitive functions were evaluated ≤21 days after middle cerebral artery occlusion. Immunostaining was used to assess infarct volume, myelin loss, and microglial activation. Bromodeoxyuridine (BrdU) was injected for measurements of proliferating NG2
+
oligodendrocyte precursor cells (OPCs) and newly generated adenomatous polyposis coli
+
oligodendrocytes. Mixed glial cultures were used to confirm the effect of rosiglitazone on oligodendrocyte differentiation and microglial polarization.

Results—

Rosiglitazone significantly reduced brain tissue loss, ameliorated white matter injury, and improved sensorimotor and cognitive functions for at least 21 days after middle cerebral artery occlusion. Rosiglitazone enhanced OPC proliferation and increased the numbers of newly generated mature oligodendrocytes after middle cerebral artery occlusion. Rosiglitazone treatment also reduced the numbers of Iba1
+
/CD16
+
M1 microglia and increased the numbers of Iba1
+
/CD206
+
M2 microglia after stroke. Glial culture experiments confirmed that rosiglitazone promoted oligodendrocyte differentiation, perhaps by promoting microglial M2 polarization.

Conclusions—
Rosiglitazone treatment improves long-term white matter integrity after cerebral ischemia, at least, in part, by promoting oligodendrogenesis and facilitating microglial polarization toward the beneficial M2 phenotype.
Facial Action and Emotional Language: ERP Evidence that Blocking Facial Feedback Selectively Impairs Sentence Comprehension
Authors: Davis Joshua D. , Winkielman Piotr , Coulson Seana 
Published: August 2015

Abstract
There is a lively and theoretically important debate about whether, how, and when embodiment contributes to language comprehension. This study addressed these questions by testing how interference with facial action impacts the brain's real-time response to emotional language. Participants read sentences about positive and negative events (e.g., “She reached inside the pocket of her coat from last winter and found some (cash/bugs) inside it.”) while ERPs were recorded. Facial action was manipulated within participants by asking participants to hold chopsticks in their mouths using a position that allowed or blocked smiling, as confirmed by EMG. Blocking smiling did not influence ERPs to the valenced words (e.g., cash, bugs) but did influence ERPs to final words of sentences describing positive events. Results show that affectively positive sentences can evoke smiles and that such facial action can facilitate the semantic processing indexed by the N400 component. Overall, this study offers causal evidence that embodiment impacts some aspects of high-level comprehension, presumably involving the construction of the situation model.
Deep-water Thyasiridae (Mollusca: Bivalvia) from the Oman Margin, Arabian Sea, new species and examples of endemism and cosmopolitanism
Authors: OLIVER P. GRAHAM 
Published: August 2015

Seven species of Thyasiridae are reported from the Oman Margin of the Arabian Sea at depths between 688 m and 3356 m. Hypoxic conditions exist at depths between 400 and 1200 m and three species are restricted to this zone and to the Arabian Sea. Leptaxinus indusarium has also been recorded from the Indus Fan and Channelaxinus investigatoris from off Sri Lanka. A new species Thyasira anassa sp. nov. is described from the hypoxic zone. Another four species are recorded from the abyssal zone where oxygen levels are typical for the deep ocean. Here another new species is described, Parathyasira bamberi sp. nov. but the other species could not be conclusively identified because of close affinity with populations from other oceans. Deep water Atlantic species Axinulus croulinensis and Mendicula ferruginosa are apparently present in the abyssal Indian Ocean while another thyasirid shell is very close to Channelaxinus excavatus from the Eastern Pacific and C. perplicata from the Atlantic. Accompanying these abyssal thyasirids were other bivalve species, Deminucula atacellana, Limopsis pelagica and Bentharca asperula that cannot be distinguished by morphology from their Atlantic populations. It is concluded that using morphology alone that the abyssal species may well be cosmopolitan in distribution.
Contrasting Influences of Recent Aerosol Changes on Clouds and Precipitation in Europe and East Asia
Authors: Stjern Camilla W. , Kristjánsson Jón Egill 
Published: August 2015

Abstract
Over the last few decades, aerosol loadings have increased greatly over Southeast Asia, while Europe and North America have experienced huge reductions. Previous studies have suggested that these changes may have influenced the temperature trends as well as precipitation patterns due to the direct and semidirect aerosol effects. Here, an Earth system model with parameterized aerosol–radiation and aerosol–cloud interactions is used to investigate changes in cloud properties and precipitation between 1975 and 2005. This is done globally as well as for the two focus areas Europe and East Asia. Despite systematic changes in cloud droplet number concentration and cloud droplet size, changes in stratiform precipitation are less clear. In both regions there is a dominance of autoconversion over liquid water accretion as the primary precipitation release mechanism, which alone should imply a strong sensitivity to changes in cloud droplet size. However, in these areas liquid water paths are relatively low and background concentrations are high, which produce low simulated precipitation susceptibilities. High susceptibilities are instead found over remote ocean regions, in agreement with expectations. For convective precipitation, both regions show statistically significant changes that are consistent with oppositely signed changes in direct aerosol forcing over Europe and East Asia, respectively.
Temperature and Wind Climate of the Antarctic Peninsula as Simulated by a High-Resolution Regional Atmospheric Climate Model
Authors: van Wessem Jan Melchior , Reijmer Carleen H. , van de Berg Willem Jan , van den Broeke Michiel R. , Cook Alison J. , van Ulft Lambertus H. , van Meijgaard Erik 
Published: August 2015

Abstract
The latest polar version of the Regional Atmospheric Climate Model (RACMO2.3) has been applied to the Antarctic Peninsula (AP). In this study, the authors present results of a climate run at 5.5 km for the period 1979–2013, in which RACMO2.3 is forced by ERA-Interim atmospheric and ocean surface fields, using an updated AP surface topography. The model results are evaluated with near-surface temperature and wind measurements from 12 manned and automatic weather stations and vertical profiles from balloon soundings made at three stations. The seasonal cycle of near-surface temperature and wind is simulated well, with most biases still related to the limited model resolution. High-resolution climate maps of temperature and wind showing that the AP climate exhibits large spatial variability are discussed. Over the steep and high mountains of the northern AP, large west-to-east climate gradients exist, while over the gentle southern AP mountains the near-surface climate is dominated by katabatic winds. Over the flat ice shelves, where katabatic wind forcing is weak, interannual variability in temperature is largest. Finally, decadal trends of temperature and wind are presented, and it is shown that recently there has been distinct warming over the northwestern AP and cooling over the rest of the AP, related to changes in sea ice cover.
A New Mechanism for Mode Water Formation involving Cabbeling and Frontogenetic Strain at Thermohaline Fronts
Authors: Thomas Leif N. , Shakespeare Callum J. 
Published: August 2015

AbstractA simple analytical model is used to elucidate a potential mechanism for steady-state mode water formation at a thermohaline front that involves frontogenesis, submesoscale lateral mixing, and cabbeling. This mechanism is motivated in part by recent observations of an extremely sharp, density-compensated front at the North Wall of the Gulf Stream. Here, the intergyre, along-isopycnal, salinity–temperature difference is compressed into a span of a few kilometers, making the flow susceptible to cabbeling. The sharpness of the front is caused by frontogenetic strain, which is presumably balanced by submesoscale lateral mixing processes. The balance is studied with the simple model, and a scaling is derived for the amount of water mass transformation resulting from the ensuing cabbeling. The transformation scales with the strain rate, equilibrated width of the front, and the square of the isopycnal temperature contrast across the front. At the major ocean fronts where mode waters are found, this isopycnal temperature contrast decreases with increasing density near the isopycnal layers where mode waters reside. This implies that cabbeling should result in a convergent diapycnal mass flux into mode water density classes. The scaling for the transformation suggests that at these fronts the process could generate 0.01–1 Sverdrups (Sv; 1 Sv ≡ 106 m3 s−1) of mode water. These formation rates, while smaller than mode water formation by air–sea fluxes, should be independent of season and thus could fill select isopycnal layers continuously and play an important role in the dynamics of mode waters on interannual time scales.
The ‘Public Interest’ in India: Contestation and Confrontation before the Supreme Court
Authors: Sen Sarbani 
Published: August 2015

AbstractThe phenomenon of Public Interest Litigation (PIL) is a judicially crafted one and primarily consists of the constitutional court's expansion of fundamental rights on the one hand, and procedural innovations to create better opportunities for disadvantaged groups to gain access to the legal system on the other. It has created a renewed conception of justice, and has enabled the court to augment and validate its own authority as the ‘guardian’ of public welfare, and as the constitutionally appointed branch of the state to enforce the rights of the ‘public’. PIL at one level appears to have enabled the justice system and laws to define and shape social and political interactions and to channelize democratic pressures for gaining a response from the state. But it has also been a process by which law and justice emerge from social and political interaction. This new interaction between the realm of judicial decision making and state governance has created adjustments and adaptations and the creation of new legal acts, as well as systemic tensions and conflicts. The paper concludes by looking at broader questions that PIL generates for processes of civic participation, representative democracy and democratic polity under the constitution.
In-hospital Breastfeeding and Intention to Return to Work Influence Mothers’ Breastfeeding Intentions
Authors: Thomas-Jackson Shera C. , Bentley Gail E. , Keyton Kristina , Reifman Alan , Boylan Mallory , Hart Sybil L. 
Published: August 2015

Background: Research continues to demonstrate that formula feeding is associated with numerous long-term negative outcomes for a mother and her infant. However, many women cease breastfeeding sooner than intended and recommended. Breastfeeding has been found to be related to demographics, maternal mood, and returning to work outside the home. Objectives: This study aimed to shed light on the woman’s perception of the effect of working on intended breastfeeding duration. This study used intentions to return to work and in-hospital breastfeeding to predict breastfeeding intentions. Methods: Women (N = 160) were surveyed during the first 48 hours postdelivery of healthy, full-term infants. Survey instruments included demographics (socioeconomic status, maternal age, education, and marital status), depression, fetal attachment, current exclusive breastfeeding status, as well as breastfeeding and return-to-work intentions for the next year. A path analysis was used to explore relationships and predictors of breastfeeding intentions. Results: The model had a good fit and breastfeeding intentions were predicted by exclusive breastfeeding in the hospital (β = 0.21, P < .01) and negatively predicted by return to work (β = −0.18, P < .05). Conclusion: Exclusive breastfeeding in the hospital within the first 48 hours postpartum and intention to return to work influence how long a mother intends to breastfeed. Attention to these areas can be provided immediately postpartum to support exclusive breastfeeding and provide informational support on continuing to breastfeed/express milk upon return to work if the mother intends to return to work.
Reliability of Lactation Assessment Tools Applied to Overweight and Obese Women
Authors: Chapman Donna J. , Doughty Katherine , Mullin Elizabeth M. , Pérez-Escamilla Rafael 
Published: August 2015

Background: The interrater reliability of lactation assessment tools has not been evaluated in overweight/obese women. Objective: This study aimed to compare the interrater reliability of 4 lactation assessment tools in this population. Methods: A convenience sample of 45 women (body mass index > 27.0) was videotaped while breastfeeding (twice daily on days 2, 4, and 7 postpartum). Three International Board Certified Lactation Consultants independently rated each videotaped session using 4 tools (Infant Breastfeeding Assessment Tool [IBFAT], modified LATCH [mLATCH], modified Via Christi [mVC], and Riordan’s Tool [RT]). For each day and tool, we evaluated interrater reliability with 1-way repeated-measures analyses of variance, intraclass correlation coefficients (ICCs), and percentage absolute agreement between raters. Results: Analyses of variance showed significant differences between raters’ scores on day 2 (all scales) and day 7 (RT). Intraclass correlation coefficient values reflected good (mLATCH) to excellent reliability (IBFAT, mVC, and RT) on days 2 and 7. All day 4 ICCs reflected good reliability. The ICC for mLATCH was significantly lower than all others on day 2 and was significantly lower than IBFAT (day 7). Percentage absolute interrater agreement for scale components ranged from 31% (day 2: observable swallowing, RT) to 92% (day 7: IBFAT, fixing; and mVC, latch time). Swallowing scores on all scales had the lowest levels of interrater agreement (31%-64%). Conclusion: We demonstrated differences in the interrater reliability of 4 lactation assessment tools when applied to overweight/obese women, with the lowest values observed on day 4. Swallowing assessment was particularly unreliable. Researchers and clinicians using these scales should be aware of the differences in their psychometric behavior.
Implementation of a Donor Milk Program Is Associated with Greater Consumption of Mothers’ Own Milk among VLBW Infants in a US, Level 3 NICU
Authors: Parker Margaret G.K. , Burnham Laura , Mao Wenyang , Philipp Barbara L. , Merewood Anne 
Published: August 2015

Background: It is unclear whether use of donor milk (DM) changes the provision of mothers’ own milk (MOM) to very low birth weight (VLBW) infants in the neonatal intensive care unit (NICU). Objectives: To determine whether (1) the rates of any MOM and human milk consumption at feeding initiation and discharge and (2) the proportion of VLBW infants who stopped consuming any MOM and human milk during hospitalization changed in the 2 years after versus before implementation of a DM program in a US, inner-city, level 3 NICU. Methods: We studied VLBW infants admitted to Boston Medical Center in the 2 years before (n = 74) and after (n = 80) implementation of a DM program (June 2011). We used multivariable logistic regression to compare milk consumption at feeding initiation and discharge and Cox proportional hazards to compare the proportion of infants that stopped consuming milk during the hospitalization pre and post our DM program. Results: After adjustment for maternal race, age, insurance, delivery type, gestational age, and birth weight, we found a 6.0-fold increased odds (95% CI, 2.0-17.7) of consuming MOM at discharge and a 49% reduction in the cessation of MOM consumption during hospitalization (hazard ratio [HR], 0.51; 95% CI, 0.28-0.93) in the 2 years after versus before our DM program. Conclusion: Implementation of a DM program was associated with greater consumption of MOM throughout hospitalization and at discharge among VLBW infants. Implementation of DM programs may augment support of mothers to provide breast milk in level 3 NICUs.
Pre-operative fMRI localization of the supplementary motor area and its relationship with postoperative speech deficits
Authors: Lyo John K , Arevalo-Perez Julio , Petrovich Brennan Nicole , Peck Kyung K , Holodny Andrei I 
Published: August 2015

Introduction Neurosurgery of the supplementary motor area (SMA) is associated with transient speech defects. We investigated whether SMA laterality correlates with postoperative speech defects. Materials and methods The authors reviewed 17 patients with SMA-area lesion resection and preoperative language fMRI. SMA laterality was calculated by comparison of voxel activation in paired SMAs by hand-drawn regions of interest (ROIs) (drawn by a neuroradiologist), and compared with qualitative assessment by two neuroradiologists. Postoperative speech defects before and after surgery were assessed by chart review. Results Six patients developed new speech defects that resolved within several months. Two of the patients had a pre-existing speech defect that had developed after prior SMA-area surgery. All these patients had left-sided lesions, while none of the four patients with a right-sided lesion developed a speech defect. Neuroradiologists’ assessment of SMA laterality agreed with ROI calculation for the SMAs that were lateralized. However, for the SMAs in the “codominant” range by ROI, the neuroradiologists felt that all but one of the cases clearly lateralized, with the exception deemed indeterminate or codominant. No correlation between laterality of SMA and speech defect was identified. Twelve patients showed lateralization contralateral to the lesion. Conclusions fMRI lateralization does not correlate with transient speech defects that developed from SMA-area surgery. Qualitative/visual assessment of SMA laterality was superior to ROI calculation because of the close proximity and possible overlap of signal from midline SMA. A majority of patients showed SMA lateralization contralateral to the SMA lesion.
Perfusion computed tomography of intracranial meningiomas: In vivo correlation of cerebral blood volume and vascular permeability
Authors: Granata Francesca , Morabito Rosa , Alafaci Concetta , Barresi Valeria , Tomasello Francesco , Vinci Sergio , Mormina Enricomaria , Calamuneri Alessandro , Grasso Giovanni , Salpietro Francesco Maria , Longo Marcello 
Published: August 2015

Background A noninvasive method to predict the grade of a meningioma would be desirable since it would anticipate information about tumour nature, recurrence and improve tumour management and outcomes. The aim of the present study was to assess the ability of perfusion computed tomography (PCT) technique in predicting the meningioma grade before surgery. Data from PCT, such as cerebral blood volume (CBV) and permeability surface (PS), were correlated with immunohistolopathological information. Methods Twenty-three patients with a diagnosis of intracranial meningioma underwent PCT for pre-surgical evaluation of CBV and PS. During surgery, samples from the centre and periphery of the tumour were obtained. Two correspondent regions of interest (ROIs) were drawn on CBV and PS maps. Central and peripheral CBV and PS mean values were calculated. PCT parameters were correlated to CD-34 and endoglin. Results There was a positive correlation between PS and CD-34. No correlation was found between PS values and endoglin, CBV values and CD-34 and endoglin values. Conclusion Our findings suggest that PCT may support conventional morphological imaging in predicting meningioma grading before surgery.