bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High-Throughput Method for the Analysis of Larval Developmental Phenotypes in Caenorhabditis elegans
Authors: Olmedo María , Geibel Mirjam , Artal-Sanz Marta , Merrow Martha 
Published: August 2015

Abstract
Caenorhabditis elegans postembryonic development consists of four discrete larval stages separated by molts. Typically, the speed of progression through these larval stages is investigated by visual inspection of the molting process. Here, we describe an automated method to monitor the timing of these discrete phases of C. elegans maturation, from the first larval stage through adulthood, using bioluminescence. The method was validated with a lin-42 mutant strain that shows delayed development relative to wild-type animals and with a daf-2 mutant that shows an extended second larval stage. This new method is inherently high-throughput and will finally allow dissecting the molecular machinery governing the speed of the developmental clock, which has so far been hampered by the lack of a method suitable for genetic screens.
Anisotropic Model for Permeability Change in Coalbed-Methane Wells
Authors: Moore Robert , Palmer (ret.) Ian , Higgs Nigel 
Published: August 2015

Summary
With depletion of coalbed-methane (CBM) wells in the San Juan basin, permeability rises by 10–100 times. Similar permeability increases are found in other CBM basins around the world. Models previously advanced to explain this behavior combine a compaction mechanism (which closes cleats) with matrix shrinkage (which opens cleats). In this paper, the original model—Palmer and Mansoori (1996, 1998)—is extended to include the transversely isotropic elastic response found in vertically cleated coals. This new version of the model has been calibrated by laboratory measurements on San Juan basin coal loaded under uniaxial-strain conditions to simulate reservoir depletion. The main goal/result is a predictive model characterized by two measured Young's moduli and three measured Poisson's ratios.
Although there exist many models that seek to explain the huge permeability increases in CBM wells, the significance of this logical extension to the Palmer-Mansoori model (Palmer and Mansoori 1996, 1998) (i.e., the addition of coal anisotropy) is that it has the ability to predict permeability increases in wells in the field by use of measurable rock moduli and other quantities, thus reducing the need for empirically derived field matching parameters. Note that this new model also confirms an empirical constant that was invoked in a previous version of the Palmer-Mansoori model (Palmer and Mansoori 1996, 1998) to account for cleat anisotropy. To illustrate the model results, permeability increases with depletion from a few wells in one area of the San Juan basin have been matched by the new model. The new model should allow better forecasting of gas rates by reservoir simulators, as well as improved predictions of gas production in fields yet to be developed.
SMART Kick Detection: First Step on the Well-Control Automation Journey
Authors: Brakel J. D. , Tarr B. A. , Cox W.. , Jørgensen F.. , Straume H. V. 
Published: August 2015

Summary
In 2010, on the basis of the safety-performance results achieved through the automation revolution in its oil and gas downstream business, an operator set out to start the same revolution in its upstream business. Automating the initial well-control response to an influx was identified as the initial focus area with the goal of assisting rig personnel to identify and stop any influx without delay. This led to a well-control automation-collaboration project started between an operator, a rig contractor, and a rig-equipment supplier. The first phase of the project was to develop a system that could detect an influx across a broad spectrum of well-construction-related rig operations. This paper describes the development, deployment, and field testing of the first upgraded kick-detection system from this collaboration.
To understand where to focus the kick-detection system-upgrade efforts, a fault-tree-style sensitivity analysis of kick detection and well shut-in procedures was undertaken. The results pointed to the high value of improved sensor data (both accuracy and reliability) and of improved detection software for alarming (both in terms of coverage and how the driller is alerted to respond to a confirmed kick condition). On the basis of this sensitivity analysis, a kick-detection system-upgrade functional specification was created and used to develop a trial-upgrade plan for a deepwater rig.
Initial implementation operational performance results are presented to demonstrate that most of the kick-detection system-upgrade objectives were achieved.
Operational feedback from using the upgraded kick-detection system is included which highlights the new, “SMART,” features that were designed to provide easily understood alerts to the driller, including unique pop-up kick-alarm windows for drilling or circulating, making a connection, and tripping in or out.
Respective associations between ureteral obstruction and renomegaly, urine specific gravity, and serum creatinine concentration in cats: 29 cases (2006–2013)
Authors: Bua Anne-Sophie , Dunn Marilyn E. , Pey Pascaline 
Published: August 2015

Abstract
Objective—To determine the respective associations between ureteral obstruction and renomegaly, urine specific gravity (USG), and serum creatinine concentration and to assess the reliability of abdominal palpation for detection of renomegaly in cats.
Design—Retrospective case series.
Animals—89 client-owned cats with (n = 29) or without ureteral obstruction and with (30) or without (30) kidney disease.
Procedures—Medical records of cats that underwent abdominal ultrasonography at a veterinary teaching hospital from January 2006 through April 2013 were reviewed. Cats were categorized as having ureteral obstruction (obstructed group) or no ureteral obstruction with (KD group) or without kidney disease (NKD group). Renomegaly and renal asymmetry were defined on the basis of mean renal length for NKD cats. Prevalence of renomegaly and renal asymmetry, mean USG and serum creatinine concentration, and abdominal palpation and ultrasonographic findings were compared among the groups.
Results—Renomegaly was identified in 2 obstructed cats and 1 KD cat and was not associated with ureteral obstruction. Renal asymmetry was detected in 18 obstructed cats and 11 KD cats. For obstructed and KD cats, the mean USG was significantly lower and the mean serum creatinine concentration was significantly greater than those for NKD cats. Twenty-eight of 29 cats with ureteral obstruction had hypercreatininemia. Abdominal palpation was not a reliable method for detection of renomegaly.
Conclusions and Clinical Relevance—Results indicated renomegaly was not associated with ureteral obstruction in cats, and abdominal palpation was an unreliable method for detection of renomegaly. The most consistent abnormal finding for cats with ureteral obstruction was hypercreatininemia. (J Am Vet Med Assoc 2015;247:518–524)
Salmonella bacteriuria in a cat fed a Salmonella-contaminated diet
Authors: Fauth Erika , Freeman Lisa M. , Cornjeo Lilian , Markovich Jessica E. , Janecko Nicol , Weese J. Scott 
Published: August 2015

Abstract
Case Description—A 9-year-old castrated male domestic shorthair cat was evaluated because of hematuria and weight loss after an 8-year history of intermittent signs of feline lower urinary tract disease (FLUTD). A complete diet history revealed that the cat was eating a commercial diet that does not undergo the same processing procedures as most pet foods and so might be at increased risk for bacterial contamination owing to a nonstandard industry cooking procedure.
Clinical Findings—The cat had a history consistent with FLUTD, but bacteriologic culture of the urine revealed Salmonella organisms. Additional analysis revealed Salmonella enterica serotype I:ROUGH-O:g,m,s:- in samples of urine and feces as well as Salmonella enterica serotype Johannesburg and Salmonella enterica serotype Senftenberg in the diet.
Treatment and Outcome—The cat responded positively to antimicrobial treatment for the Salmonella bacteriuria as well as to dietary and environmental management for the clinical signs associated with FLUTD.
Clinical Relevance—Findings in this case highlighted an additional health consequence associated with ingestion of Salmonella-contaminated food. Such contamination is of particular concern with raw meat–based diets or diets that have not undergone standard industry cooking practices. Veterinarians should obtain a diet history for every companion animal during every evaluation to help with diagnosis and optimal treatment. (J Am Vet Med Assoc 2015;247:525–530)
Management of a pet dog after exposure to a human patient with Ebola virus disease
Authors: Spengler Jessica R. , Stonecipher Shelley , McManus Catherine , Hughes-Garza Holly , Dow Max , Zoran Debra L. , Bissett Wesley , Beckham Tammy , Alves Derron A. , Wolcott Mark , Tostenson Samantha , Dorman Bill , Jones Jody , Sidwa Thomas J. , Knust Barbara , Behravesh Casey Barton 
Published: August 2015

Abstract
In October 2014, a health-care worker who had been part of the treatment team for the first laboratory-confirmed case of Ebola virus disease imported to the United States developed symptoms of Ebola virus disease. A presumptive positive reverse transcription PCR assay result for Ebola virus RNA in a blood sample from the worker was confirmed by the CDC, making this the first documented occurrence of domestic transmission of Ebola virus in the United States. The Texas Department of State Health Services commissioner issued a control order requiring disinfection and decontamination of the health-care worker's residence. This process was delayed until the patient's pet dog (which, having been exposed to a human with Ebola virus disease, potentially posed a public health risk) was removed from the residence. This report describes the movement, quarantine, care, testing, and release of the pet dog, highlighting the interdisciplinary, one-health approach and extensive collaboration and communication across local, county, state, and federal agencies involved in the response. (J Am Vet Med Assoc 2015;247:531–538)
Bioabsorbable Steroid-Releasing Sinus Implants in the Frontal and Maxillary Sinuses: 2-Year Follow-Up
Authors: Matheny Keith E. 
Published: August 2015

Background Mometasone furoate-releasing implants have been approved for use in the ethmoid sinuses following endoscopic sinus surgery (ESS) to reduce the need for medical and surgical intervention postoperatively. Outcomes have not yet been studied when these implants are utilized in other paranasal sinuses after ESS. Objective To present a case in which bioabsorbable steroid-eluting implants were used to maintain patency and to decrease inflammation in the frontal and maxillary sinuses after revision ESS. Methods 52-year-old male with lifelong allergic rhinitis, chronic allergic fungal rhinosinusitis, and inflammatory bowel disease had previously undergone four endoscopic sinus surgeries, subcutaneous injection immunotherapy, and topical therapy with budesonide and amphotericin sinus irrigations. In July, 2012, during revision left frontal sinusotomy and right maxillary antrostomy (the fifth ESS), two bioabsorbable steroid-releasing implants were placed in the left frontal recess and the right maxillary sinus respectively and followed clinically, endoscopically, and radiographically for two years. Results Two year followup demonstrated near complete clinical, endoscopic, and radiographic resolution of the patient's signs and symptoms of chronic rhinosinusitis. Conclusions The steroid-releasing implants during the critical phase of wound-healing appear to have allowed the patient, now over two years postoperatively, to achieve a healthier state and to allow more successful management than the preceding 15–20 years.
Commentary on Gender Differences in Prevalence, Treatment, and Quality of Life of Patients with Chronic Rhinosinusitis
Authors: Ference Elisabeth H. , Tan Bruce K. , Hulse Kathryn E. , Chandra Rakesh K. , Smith Sean B. , Kern Robert C. , Conley David B. , Smith Stephanie Shintani 
Published: August 2015

Objective To examine the existing evidence on gender differences in the prevalence, treatment, and quality of life of patients with chronic rhinosinusitis (CRS). Methods Review of the literature and expert opinion. Results From a sociologic standpoint, women have historically been considered more likely to report symptoms, seek medical care, and give poorer self-evaluation of health, which may bias data toward increased prevalence and a greater effect of CRS on quality of life in women. However, the influence of gender seems to be restricted primarily to the evaluation of general quality of life, whereas the disease-specific health-related quality of life is not different between genders. Furthermore, migraine headaches, which are more common among women, may be misdiagnosed as CRS, which contributes to gender differences in the prevalence of CRS. The degree to which reported differences in prevalence and health utilization represent biologic or physiologic differences between genders is not known; however, differences in anatomic size, tobacco susceptibility, and hormonal factors have been speculated to increase the overall susceptibility to CRS in women compared with men. Conclusions Focused research that examines the effect of gender on the development, treatment, and outcomes of CRS is warranted.
Assessment of Allergen-Induced Respiratory Hyperresponsiveness before the Prescription of a Specific Immunotherapy
Authors: Olivier Celso Eduardo , Argentão Daiana Guedes Pinto , Lima Regiane Patussi dos Santos , da Silva Mariana Dias , Gonçalves dos Santos Raquel Acácia Pereira , Fabbri Natalia 
Published: August 2015

Background Asymptomatic sensitization is a frequent condition that must be considered before the indication of allergic-specific immunotherapy. Objective The aim of this study was to appreciate and correlate the local and spirometric changes elicited by the allergen-specific nasal provocation test (NPT) to define practical and feasible guidelines for the allergist/immunologist to demonstrate specific respiratory hyperresponsiveness before the indication of allergic-specific immunotherapy. Methods A total of 172 subjects (children and adults) with a diagnosis of allergic rhinitis were submitted to flow-volume spirometry immediately before and after the NPT performed with Dermatophagoides antigens. The differences between the pre- and postspirometric estimated values of peak expiratory flow rate (PEFdif%), forced expiratory volume in 1 second (FEV1dif%), and forced vital capacity (FVCdif%) were correlated with the results of the nasal provocation test symptom score (NPT-SS). Results There were 119 subjects (69%) with NPT-SS > 2. Among these patients who were reactive, the mean NPT-SS was 6.3. The Spearman's correlation between PEFdif% and NPT-SS was r = −0.44 (p = 0.01); the Spearman's correlation between FEV1dif% and NPT-SS was r = −0.22 (p = 0.01), and the Spearman's correlation between FVCdif% and NPT-SS was r = −0.21 (p = 0.04). Conclusion The combined utilization of the allergen-specific NPT-SS with the spirometry (or PEF meter) is a safe methodology to evaluate allergen-specific nasal and bronchial hyperresponsiveness (which sometimes acts as a bronchial provocation test) in patients with allergic rhinitis and asthma due to hypersensitivity who are candidates for allergen-specific immunotherapy.
Nasal Histamine Responses in Nonallergic Rhinitis with Eosinophilic Syndrome
Authors: Zambetti Giampietro , Ciofalo Andrea , Romeo Raffaello , Soldo Pietro , Fusconi Massimo , Greco Antonio , Magliulo Giuseppe , de Vincentiis Marco 
Published: August 2015

Background Nonallergic rhinitis with eosinophilic syndrome (NARES) is persistent, without atopy, but with ≥25% nasal eosinophilia. Hypereosinophilia seems to contribute to nasal mucosa dysfunction. Objectives This analytical case-control study aimed at assessing the presence and severity of nonspecific nasal hyperactivity and at finding out whether eosinophilia may be correlated with the respiratory and mucociliary clearance functions. Materials The symptom score was assessed in 38 patients and 15 controls whose nasal smear was also tested for eosinophils and mucociliary transport (MCT). Nonspecific nasal provocation tests (NSNPT) with histamine were also carried out, and total nasal resistance (TNR) was determined. Results The symptom score of NARES after NSNPT were not significantly different from the control group, and there was poor or no correlation among the single symptoms and the differences studied for every nasal reactivity class. This correlation improved when using the composite symptom score. The most severe eosinophilia was observed in high reactivity groups, and it was correlated with an increase in TNR. MCT worsened as eosinophilia and nasal reactivity increased. Unlike controls, a significant correlation was observed between the increase in MCT and TNR. Conclusions In NARES, nonspecific nasal hyperreactivity is the result of epithelial damage produced by eosinophilic inflammation, which causes MCT slow down, an increase in TNR, and nasal reactivity classes, with possible impact on classification, prognosis, and treatment control.
Steroid Sparing Effect of Omalizumab in Seropositive Allergic Bronchopulmonary Aspergillosis
Authors: Beam Keith T. , Coop Christopher A. 
Published: August 2015

Background Allergic bronchopulmonary aspergillosis (ABPA) is a common serious hypersensitivity reaction to airway colonization with Aspergillus in patients with asthma or cystic fibrosis. While steroids are effective in controlling the respiratory symptoms of ABPA, they have many side effects that make them undesirable for long term use. Antifungals have been used to reduce dependency on systemic steroids but long term use can be limited by side effects and there is the possibility of developing resistance to azoles. Some clinicians have successfully used anti-immunoglobulin E (anti-IgE) therapy in various populations, though it is frequently added to antifungals. Objective Further describe the utility of anti-IgE therapy for ABPA for patients unable to tolerate antifungals. Methods We describe the case of a patient with serologic ABPA who did not tolerate therapy with antifungals but was able to significantly reduce her average daily steroid use while receiving anti-IgE therapy with omalizumab added to her other respiratory medications. Results After therapy with omalizumab, our patient was able to reduce her need for daily corticosteroids by nearly 80%. Conclusions Omalizumab may reduce corticosteroid dependence in patients with allergic bronchopulmonary aspergillosis for patients unable to tolerate antifungals, though use may be limited by cost. Additional studies are needed. ClinicalTrial.gov identifier NCT00787917.
Bilateral Meningoencephaloceles with Cerebrospinal Fluid Rhinorrhea after Facial Advancement in the Crouzon Syndrome
Authors: Panuganti Bharat A. , Leach Matthew , Antisdel Jastin 
Published: August 2015

Background Cerebrospinal fluid (CSF) rhinorrhea and encephaloceles are rare complications of craniofacial advancement procedures performed in patients with craniofacial dysostoses (CD) to address the ramifications of their midface hypoplasia including obstructed nasal airway, exorbitism, and impaired mastication. Surgical repair of this CSF rhinorrhea is complicated by occult elevations in intracranial pressure (ICP), potentially necessitating open, transcranial repair. We report the first case in otolaryngology literature of a patient with Crouzon syndrome with late CSF rhinorrhea and encephalocele formation after previous LeFort III facial advancement surgery. Objectives Describe the case of a patient with Crouzon syndrome who presented with CSF rhinorrhea and encephaloceles as complications of Le Fort III facial advancement surgery. Review the literature pertaining to the incidence and management of post-operative CSF rhinorrhea and encephaloceles. Analyze issues related to repair of these complications, including occult elevations in ICP, the utility of perioperative CSF shunts, and the importance of considering alternative repair schemes to the traditional endonasal, endoscopic approach. Methods Review of the literature describing CSF rhinorrhea and encephalocele formation following facial advancement in CD, focusing on management strategies. Results CSF rhinorrhea and encephalocele formation are rare complications of craniofacial advancement procedures. Occult elevations in ICP complicate the prospect of permanent surgical repair, potentially necessitating transcranial repair and the use of CSF shunts. Though no consensus exists regarding the utility of perioperative CSF drains, strong associations exist between elevated ICP and failed surgical repair. Additionally, the anatomic changes in the frontal and ethmoid sinuses after facial advancement present a challenge to endoscopic repair. Conclusion Otolaryngologists should be aware of the possibility of occult elevations in ICP and sinonasal anatomic abnormalities when repairing CSF rhinorrhea in patients with CD. Clinicians should consider CSF shunt placement and carefully weigh the advantages of the transcranial approach versus endonasal, endoscopic techniques.
Facilitating Community-Based Exercise for People With Stroke: Cross-Sectional e-Survey of Physical Therapist Practice and Perceived Needs
Authors: Lau Carrie , Chitussi Danielle , Elliot Sarah , Giannone Jennifer , McMahon Mary-Katherine , Sibley Kathryn M. , Tee Alda , Matthews Julie , Salbach Nancy M. 
Published: August 2015

Background
Educating people with stroke about community-based exercise programs (CBEPs) is a recommended practice that physical therapists are well positioned to implement.

Objective
The aim of this study was to evaluate the provision of education about CBEPs to people with stroke, barriers to providing education, and preferences for resources to facilitate education among physical therapists in neurological practice.

Design
A cross-sectional e-survey of physical therapists treating adults with stroke in Ontario, Canada, was conducted.

Methods
A link to the questionnaire was emailed to physical therapists in a provincial stroke network, a provincial physical therapy association, and on hospital and previous research lists.

Results
Responses from 186 physical therapists were analyzed. The percentage of respondents who reported providing CBEP education was 84.4%. Only 36.6% reported typically providing education to ≥7 out of 10 patients with stroke. Physical (90.5%) and preventative (84.6%) health benefits of exercise were most frequently discussed. Therapists reported most commonly delivering education at discharge (73.7%). Most frequently cited barriers to educating patients were a perceived lack of suitable programs (53.2%) and a lack of awareness of local CBEPs (23.8%). Lists of CBEPs (94.1%) or brochures (94.1%) were considered to be facilitators. The percentage of physical therapists providing CBEP education varied across acute, rehabilitation, and public outpatient settings.

Limitations
The percentage of physical therapists providing education may have been overestimated if respondents who deliver CBEP education were more likely to participate and if participants answered in a socially desirable way.

Conclusions
Even though a high proportion of physical therapists provide CBEP education, education is not consistently delivered to the majority of patients poststroke. Although a CBEP list or brochure would facilitate education regarding existing CBEPs, efforts to implement CBEPs are needed to help overcome the lack of suitable programs.