bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic cholecystectomy and laparoscopic common bile duct exploration for cholecystolithiasis and choledocholithiasis in a patient with situs inversus totalis: A case report
Authors: Matsuura Hirokazu , Haruta Hidenori , Suzuki Takamichi , Kusama Daisuke , Shinohara Shoichi , Hishikawa Shuji , Kojima Masayuki 
Published: June 2024

AbstractSitus inversus complicates diagnosis and treatment due to the mirrored organ placement in relation to normal anatomy. This report describes a 78‐year‐old female patient with situs inversus totalis who underwent laparoscopic cholecystectomy and laparoscopic common bile duct exploration for cholecystolithiasis and choledocholithiasis. Utilizing the “French mirror technique” for port placement, the surgeon adeptly mirrored standard maneuvers with a 2‐mm needle forceps in the left hand and a 5‐mm forceps in the right in a reversed anatomical setting. This technique maintained familiar hand movements, despite the patient's unique anatomy. The surgeon applied transcystic ductal bile duct exploration, using choledochoscopy for duct exploration and a basket catheter for stone removal. Laparoscopic cholecystectomy and common bile duct exploration through the transcystic ductal route are viable and effective for patients with situs inversus.
Cholesterol transfer to high‐density lipoprotein in obesity and the effects of weight loss after bariatric surgery
Authors: de Oliveira Wilson Pascoalino Camargo , Freitas Fatima Rodrigues , Costa Maurício Tavares , Silva Aline de Oliveira , de Cleva Roberto , Kalil Filho Roberto , Santo Marco Aurélio , Maranhão Raul Cavalcante 
Published: June 2024

SummaryObesity increases serum triglycerides and decreases high‐density lipoprotein cholesterol (HDL‐C). The objective is to explore some functions of HDL, cholesterol transfers and antioxidant, in subjects with grade I (G1‐OB) and III (G3‐OB) obesity and effects of bariatric surgery on G3‐OB. Fifteen G3‐OB patients (43 ± 6 years, BMI 49 ± 3 kg/m2) were studied before and 1 year after bariatric surgery; 15 G1‐OB (32 ± 2 years, 32 ± 2 kg/m2) and 15 normal weight (NW) (38 ± 6 years, 22 ± 1 kg/m2) were also studied. HDL diameter, cholesterol transfer to HDL and antioxidant capacity of HDL were determined. G3‐OB had higher triglycerides and lower HDL‐C; G1‐OB had higher triglycerides than NW but HDL‐C was equal. Compared to NW, HDL size was smaller in G3‐OB but equal in G1‐OB. One year after bariatric surgery, BMI and triglycerides of G3‐OB decreased (p < .0001 and p = .0012, respectively) and HDL‐C increased (p < .0001), equalling of NW group. Antioxidant capacity and cholesterol transfers were not different in groups and were unchanged 1 year after bariatric surgery in G3‐OB. HDL antioxidant capacity and transfer of cholesterol to HDL were not defective in obesity despite HDL‐C reduction and smaller HDL size. In addition, pronounced weight loss by bariatric surgery did not change those protective functions.
Using electronic health records for clinical pharmacology research: Challenges and considerations
Authors: Jafari Eissa , Blackman Marisa H. , Karnes Jason H. , Van Driest Sara L. , Crawford Dana C. , Choi Leena , McDonough Caitrin W. 
Published: June 2024

AbstractElectronic health records (EHRs) contain a vast array of phenotypic data on large numbers of individuals, often collected over decades. Due to the wealth of information, EHR data have emerged as a powerful resource to make first discoveries and identify disparities in our healthcare system. While the number of EHR‐based studies has exploded in recent years, most of these studies are directed at associations with disease rather than pharmacotherapeutic outcomes, such as drug response or adverse drug reactions. This is largely due to challenges specific to deriving drug‐related phenotypes from the EHR. There is great potential for EHR‐based discovery in clinical pharmacology research, and there is a critical need to address specific challenges related to accurate and reproducible derivation of drug‐related phenotypes from the EHR. This review provides a detailed evaluation of challenges and considerations for deriving drug‐related data from EHRs. We provide an examination of EHR‐based computable phenotypes and discuss cutting‐edge approaches to map medication information for clinical pharmacology research, including medication‐based computable phenotypes and natural language processing. We also discuss additional considerations such as data structure, heterogeneity and missing data, rare phenotypes, and diversity within the EHR. By further understanding the complexities associated with conducting clinical pharmacology research using EHR‐based data, investigators will be better equipped to design thoughtful studies with more reproducible results. Progress in utilizing EHRs for clinical pharmacology research should lead to significant advances in our ability to understand differential drug response and predict adverse drug reactions.
The dynamics of product and labour market power: Evidence from Lithuania
Authors: Ding Ziran , Garcia‐Louzao Jose , Jouvanceau Valentin 
Published: June 2024

AbstractThis paper characterizes the power dynamics of firms in product and labour markets in Lithuania between 2004 and 2018. We first show that both markets are not perfectly competitive, as both price markups and wage markdowns are far from unitary and homogeneous. We show that the dynamics of these margins followed different patterns. On the one hand, dispersion and the economy‐wide markup have increased, suggesting an increase in product market power. On the other hand, we document a decline in monopsony power, as heterogeneity and the aggregate markdown have declined. Altogether, our results underscore the importance of jointly analyzing product and labour markets when assessing firms' market power.
Mental health and quality of life of individuals with epilepsy during the war in Ukraine
Authors: Dubenko Andriy , Morelli Rinaldo , Cross J. Helen , Hall Julie , Kharytonov Volodymyr , Michaelis Rosa , Wiebe Samuel ,   the ILAE Emergency Task Force for Ukraine
Published: June 2024

AbstractObjectiveTo investigate the repercussions of the war in Ukraine on people with epilepsy (PWE), focusing on access to health care, seizure control, quality of life (QoL), psychological distress, anxiety, and depression; and to identify the key factors influencing these measures.MethodsConsecutive PWE, ≥18 years of age, presenting to one of seven health centers across Ukraine were invited to complete a self‐administered survey in 2023. The survey gathered information on clinical and demographic aspects, geographic displacement, and access to care and medications. It also contained five valid questionnaires exploring psychological distress (Kessler‐10), QoL with the EuroQOL‐5D‐5L (EQ‐5D‐5L), depression with the Neurological Disorders in Epilepsy scale (NDDIE), anxiety with the Hospital Anxiety and Depression Scalae‐Anxiety (HADS‐A), and epilepsy severity with the Global Assessment of the Severity of Epilepsy scale (GASE). Multivariate linear regression models assessed the relationship between measures of mental health and QoL and their potential predictors. Ethical approval was obtained from the Institute of Neurology, Psychiatry and Narcology of NAMS of Ukraine, Ukraine.ResultsAmong 305 participants (mean age 38 years), 40% were female and 44% had to change residence because of the war. Seizures worsened during the war in 52% of those with active epilepsy and 42% of those with well‐controlled epilepsy. Difficulties accessing health care and anti‐seizure medications occurred in 25% and 34% of PWE, respectively, and was worse among those who were displaced. According to the mental health instruments, 46% suffered psychological distress, 62% experienced anxiety, 50% were depressed, and 59% rated their epilepsy as somewhat severe or worse. Statistically significant predictors of psychological distress, anxiety, and depression included female gender, more severe epilepsy, increased seizures during the war, and requiring mental health support.SignificanceThe war significantly disrupted access to health care and availability of medication in PWE, who suffer from significant anxiety, depression, and psychological distress. We identify high‐risk factors that can guide resource allocation for prevention and treatment.
Helicobacter pylori Infection Does Not Protect Against Allergic Diseases: Evidence From a Pediatric Cohort From Northern Sardinia, Italy
Authors: Dore Maria Pina , Meloni Gianfranco , Bassu Ica , Pes Giovanni Mario 
Published: June 2024

ABSTRACTBackgroundThe “hygiene hypothesis” states that reduced exposure to microbial antigens due to an excessively hygienic environment can increase the risk of developing autoimmune diseases, including atopic disorders and asthma. In recent decades, there has been a progressive decline in the prevalence of numerous microorganisms following improved hygienic‐sanitary conditions. More specifically, several studies reported an inverse association between the reduction in Helicobacter pylori infection and the rise of asthma and allergic disorders.AimTo evaluate the prevalence of atopic disorders in a pediatric population in relation to seropositivity against H. pylori.MethodsChildren from Northern Sardinia, Italy, referred to the local Children's Hospital for any reason, were investigated to identify risk factors, especially H. pylori infection, associated with atopic disorders. A validated questionnaire, including demographics, house size, history of breastfeeding, residence, school or daycare center attendance, exposure to animals, and a defined diagnosis of atopy—including asthma—was filled out by a trained pediatrician according to parents' answers and child records. A blood sample was collected from each participant and immunoglobulin G against H. pylori was assessed by a locally validated ELISA test.ResultsThe seroprevalence of H. pylori infection was 11.7% among 492 children (240 females). Thirty‐two children had a confirmed diagnosis of asthma and 12 of allergy. No one child showed both conditions. Statistically significant differences in H. pylori seropositivity were not detected between children with or without atopy (8.4% vs. 12.6; p = 0.233). Although atopic disorders were more frequent in children exposed to traditional atopic risk factors, none of them showed to be significant after adjusting for all covariates.ConclusionsSerologically assessed H. pylori infection was not significantly associated with a reduced risk of atopic diseases in children.
Foraging for oviposition sites in the Hessian fly: random and non‐random aspects of movement
Authors: WITHERS T. M. , HARRIS M. O. 
Published: June 2024

Abstract

Movements of ovipositing Hessian flies (Diptera: Cecidomyiidae), were quantified in plant arrays that varied in one of three ways: (i) in distances between patches of host plants, (ii) in the size of host plant patches, and (iii) in the density of host plants within arrays of non‐host plants. Durations and frequencies of a range of behaviours were quantified, with the expectation that females would adjust some, but not necessarily all, behaviours when the distribution of host and non‐host plants was altered.
Foraging behaviours that were adjusted when plant distribution was altered were seen as evidence for non‐random movement (sensu Morris & Kareiva, 1991), Non‐random components of movement consisted of non‐random settlement on host plants and area‐restricted search after visiting host plants. Ovipositing females also exhibited directed responses to plants; however, directed responses appeared to be based on generalized visual stimuli from grasses rather than species‐specific plant stimuli (e.g. odours).
Several behavioural parameters did not change when plant arrays were altered. Females stayed in wheat patches for relatively constant periods of time and laid similar numbers of eggs before leaving wheat patches regardless of the number of plants in the patch or the time taken to find the patch.
Non‐random movements resulted in the placement of eggs on hosts rather than non‐hosts, while random movement contributed to egg laying over larger areas.
Paediatric infective endocarditis: 19‐year experience at a tertiary care hospital in it developing country
Authors: Bitar FF , Jawdi RA , Dbaibo GS , Yunis KA , Gharzeddine W , Obeid M 
Published: June 2024

Bitar FF, Jawdi RA. Dbaibo GS, Yunis KA, Gharzeddine W. Obeid M. Paediatric infective endocarditis: 19‐year experience at a tertiary care hospital in a developing country. Acta Pædiatr 2000; 89: 427‐30. Stockholm ISSN 0803‐5253A retrospective study was undertaken to study children who presented with infective endocarditis (IE) to a university teaching hospital in Beirut, Lebanon, between January 1977 and May 1995. Of 41 patients with IE (24f, 17M), 28 (68%) were diagnosed between 1977 and 1985. Patients' ages ranged from 3 to 18 y (mean age 11.3 ± 2.8 y), and 13 patients were <10 y of age. Clinical presentations included: fever (in 88%), heart failure (in 39%), neurologic findings (in 20%) and embolic phenomena (in 22%). Nineteen patients (46%) had underlying congenital heart disease (CHD) with tetralogy of Fallot and pulmonary stenosis being the most common. Sixteen patients (39%) had underlying rheumatic heart disease (RHD). A total of 5 children (12%) with normal cardiac anatomy had IE. One had underlying acquired viral myocarditis with mitral insufficiency. Echocardiography showed vegetations in 60%. Blood cultures were positive in 31 patients (76%). IE occurred in three patients following cardiac surgery. In one patient it occurred within 2 mo of surgery and in the other two it occurred within 6 mo. Streptococcus viridans and Staphylococcus aureus were the two most commonly isolated bacteria. Overall mortality rate was 29% (not statistically significant between patients presenting between 1977‐1985 and 1986‐1995; p = 0.17). There was no statistically significant difference in mortality among the groups (five in the group with CHD, six with RHD and one with structurally normal heart).
Developing genetic tools to control the Oriental fruit fly: Potential approaches and target genes
Authors: Traoré Nouhoun , Galizi Roberto , Kientega Mahamadi , Maïga Hamidou , Nébié Karim , Dabiré Rémy A. , Belem Adrien M. G. , Diabaté Abdoulaye 
Published: June 2024

AbstractThe Oriental fruit fly, Bactrocera dorsalis, is a pest of significant economic interest that damages horticulture and causes major economic losses worldwide. The main control measures are based on insecticides, which are being increasingly restricted due to the development of genetic resistance. Therefore, there is a crucial need for a novel, sustainable, and environmentally safe means of controlling this pest. Advances in genome editing, aided by the discovery of CRISPR‐Cas9 tools and the development of gene drive systems, offer new alternatives for combating insect pests and vectors. Genetic suppression tools targeting key parameters could become powerful assets within the AW‐IPM programme for controlling B. dorsalis. This literature review provides an overview of currently characterized genes that could be targeted for genetic suppression of B. dorsalis.
Realist process evaluation of the knowledge translation programme of a patient‐oriented research network
Authors: Yamaguchi Sakiko , Zerbo Alix , Cardoso Roberta , Elsabbagh Mayada , Gitterman Aryeh , Glegg Stephanie , Gonzalez Miriam , Putterman Connie , Weiss Jonathan A. , Shikako Keiko ,   CHILD‐BRIGHT Knowledge Translation Program Committee
Published: June 2024

AbstractRationaleThe Knowledge Translation (KT) Programme of a pan‐Canadian strategic patient‐oriented research network focused on brain‐based developmental disabilities aimed to mobilize knowledge relevant to the network members. The programme also promotes and studies integrated Knowledge Translation (iKT) approaches involving different interested parties, such as researchers, patient‐partners and decision‐makers, in all parts of the knowledge creation process.Aims and ObjectivesThe objective of this study is to advance research programme evaluation methods through a realist evaluation of the process of implementing iKT activities.MethodsRealist process evaluation included: (1) development of initial programme theories (using the partnership synergy theory); (2) data collection and analysis; (3) synthesis and refinement of theories through engagement with literature; and (4) presentation of findings in context‐mechanism‐outcome (C‐M‐O) configurations. A range of project documentation records were reviewed for analysis, and three co‐leads, a programme coordinator, and a senior research associate were consulted to contextualize the implementation process of relevant KT activities.ResultsBased on the developed C‐M‐O configurations, we identified five key mechanisms of generating synergy in the iKT processes: (1) Visible shared leadership that embodies what iKT looks like; (2) Researchers' readiness for iKT; (3) Adaptation and flexible allocation of resources to emerging needs; (4) Power sharing to create practical and creative knowledge; and (5) Collective voice for potential transformative impacts at the policy level.ConclusionsThe current realist evaluation demonstrated how partnerships between researchers, patient‐partners and other interested parties can synergistically generate new ways of thinking among all interested parties, actionable strategies to integrate users in research, and solutions to disseminate knowledge. In particular, we identified a pivotal role for patient‐partners to act as equal decision‐maker helps building and maintaining partnerships and consolidating KT strategies.
Importance of early consideration of scaling and sustainability for aging‐related care models: Case study of Hospital at Home
Authors: Siu Albert L. , Leff Bruce 
Published: June 2024

AbstractFor aging‐related research, there is a pressing need to attend to the dissemination and implementation of evidence‐based interventions. Some aging‐related interventions with established effectiveness may be poorly disseminated and implemented due to behavioral, organizational, payment, or other constraints. To provide insight into the beginning to end process of translation and implementation, we present a case history of the three‐decade progression of Hospital at Home (HaH) now nearing national dissemination. We summarize research at various phases with particular attention to implementation considerations. Reviewing over three decades of HaH‐related research dating from initial discovery to translation and implementation, we found that the content and importance of different constructs (e.g., inner practice vs. outer environmental setting) and the choice of implementation strategies differed depending on implementation context (testing of effectiveness, scaling, or sustainability). Early effectiveness studies mostly examined implementation issues related to the intervention, the practice setting, and the individuals involved. However, explicit and early consideration of scale and sustainment was not the primary focus. For example, HaH program intake is primarily through hospital emergency departments (ED). Initial efforts would have benefited from incorporating strategies (e.g., incorporating ED leadership into program leadership) to address night and weekend admissions. Many regulatory barriers did not surface during initial considerations. Considering implementation issues late may contribute to delay in bringing discoveries to population impact. The experience with HaH suggests that scale and sustainability bear earlier consideration because barriers and facilitators to implementation are likely to be different in content and importance at different phases of implementation.
The impact of glycine and glutamate, as components of glutathione precursors, on the productivity, digestive performance and blood profile of weaning pigs
Authors: Wahid Sumaya Tanzin , Lee Sang Seon , Kim In Ho 
Published: June 2024

AbstractThe impact of glycine and glutamate, as components of glutathione (GSH) precursors, was studied as a factor in determining the growth rate of weaning pigs, their digestion of nutrient supplements and their blood concentration levels. There were 180 crossbred weaning pigs with an average body weight (BW) of 7.94 ± 1.53 kg (five pigs per pen [two barrows and three gilts]; nine pens per treatment) that were randomly assigned to one of four diets. We used a basal diet as the control, TRT1 as the treatment with 0.10% precursor of GSH, TRT2 as the treatment with 0.20% precursor of GSH and TRT3 as the treatment with 0.30% precursor of GSH. The BW of weaning pigs exhibited a linear increase on days 7 (p < 0.001), 21 (p < 0.001) and 42 (p < 0.009) following the supplementation with the GSH precursor. Supplementation with GSH precursor led to a consistent and gradual increase in average daily gain (ADG) on days 8–21, 22–42 and overall, as indicated by a significant linear trend (p < 0.05). G: F was linearly increased (p < 0.05) on days 22–42 and overall with the increment in the precursor of GSH supplementation. However, GSH precursor supplementation did not have any impact on nutrient digestibility and blood profile in the treatment group. In summary, the administration of GSH precursor improved BW, ADG and G: F ratio while not affecting nutrient digestibility or blood profile.
Okeanomitos corallinicola gen. and sp. nov. (Nostocales, Cyanobacteria), a new toxic marine heterocyte‐forming Cyanobacterium from a coral reef
Authors: Li Haiyan , Li Renhui , Kang Jianhua , Hii Kieng Soon , Mohamed Hala F. , Xu Xinya , Luo Zhaohe 
Published: June 2024

AbstractCyanobacterial mats supplanting coral and spreading coral diseases in tropical reefs, intensified by environmental shifts caused by human‐induced pressures, nutrient enrichment, and global climate change, pose grave risks to the survival of coral ecosystems. In this study, we characterized Okeanomitos corallinicola gen. and sp. nov., a newly discovered toxic marine heterocyte‐forming cyanobacterium isolated from a coral reef ecosystem of the South China Sea. Phylogenetic analysis, based on the 16S rRNA gene and the secondary structure of the 16S–23S rRNA intergenic region, placed this species in a clade distinct from closely related genera, that is, Sphaerospermopsis stricto sensu, Raphidiopsis, and Amphiheterocytum. The O. corallinicola is a marine benthic species lacking gas vesicles, distinguishing it from other members of the Aphanizomenonaceae family. The genome of O. corallinicola is large and exhibits diverse functional capabilities, potentially contributing to the resilience and adaptability of coral reef ecosystems. In vitro assays revealed that O. corallinicola demonstrates notable cytotoxic activity against various cancer cell lines, suggesting its potential as a source of novel anticancer compounds. Furthermore, the identification of residual saxitoxin biosynthesis function in the genome of O. corallinicola, a marine cyanobacteria, supports the theory that saxitoxin genes in cyanobacteria and dinoflagellates may have been horizontally transferred between them or may have originated from a shared ancestor. Overall, the identification and characterization of O. corallinicola provides valuable contributions to cyanobacterial taxonomy, offering novel perspectives on complex interactions within coral reef ecosystems.