bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular characterization and targeted therapeutic approaches in breast cancer
Authors: Toss Angela , Cristofanilli Massimo 
Published: April 2015

AbstractDespite the wide improvements in breast cancer (BC) detection and adjuvant treatment, BC is still responsible for approximately 40,000 deaths annually in the United States. Novel biomarkers are fundamental to assist clinicians in BC detection, risk stratification, disease subtyping, prediction of treatment response, and surveillance, allowing a more tailored approach to therapy in both primary and metastatic settings. In primary BC, the development of molecular profiling techniques has added prognostic and predictive information to conventional biomarkers - estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2. Moreover, the application of next-generation sequencing and reverse-phase protein microarray methods in the metastatic setting holds the promise to further advance toward a personalized management of cancer. The improvement in our understanding on BC biology associated with the study of the genomic aberrations characterizing the most common molecular subtypes allows us to explore new targets for drug development. Finally, the integration of cancer stem cell-targeted therapies and immune therapies in future combination regimens increases our chances to successfully treat a larger proportion of women with more aggressive and resistant metastatic disease. This article reviews the current state of novel biological markers for BC, the evidence to demonstrate their clinical validity and utility, and the implication for therapeutic targeting.
Influence of land use/land cover on the water chemistry of Wular Lake in Kashmir Himalaya (India)
Authors: Hassan Zahoor ul , Shah Javaid Ahmad , Kanth Tasawoor Ahmad , Pandit Ashok Kumar 
Published: April 2015

Abstract

Introduction
The impacts of land use/land cover (LULC) pattern on surface components of water are less well recognized, particularly in the Kashmir Himalaya. The paper highlights the relationship between LULC and water chemistry for Wular Lake in Kashmir Himalaya.

Methods
We used Indian Remote Sensing satellite (IRS) P6 using LISS III sensor with a spatial resolution of 23.5 m for various LULC categories. ERDAS IMAGINE 9.0 and ArcGIS 9.3 were used to generate the LULC map. Water parameters like pH and temperature were measured in the field, while parameters like dissolved oxygen, free carbon dioxide, chloride, alkalinity nitrogen and phosphorus values were determined by APHA (Standard Methods for Examination of Water and Wastewater, 1998).

Results
The present study provides us the information about the proportion of different land cover categories and their correlation with some limnological parameters of Wular Lake. Among the various physicochemical parameters, low dissolved oxygen (DO) was observed in the LULC class which has the highest percentage of agricultural land (47.04%; r = 0.688 P < 0.05) followed by horticultural land (19.10%; r = 0.554; P < 0.01) in its catchment. The catchment area with greater percentage of agricultural fields drains maximum fertilizers in the lake, resulting in growth of microorganisms that deplete the dissolved oxygen content in the water body.

Conclusions
Pearson matrix predicts that agricultural land, built up, horticultural land and wasteland seem to be the foremost factors responsible for the deterioration of the water quality of the lake. Careful planning of land use is needed to bring significant reductions in nutrient exports from agriculture through various tributaries, in order to restore and maintain water quality of the lake. If this trend of agriculturization manifestation continues unabated, it will be difficult to restore the lake water quality and to subsequently correct ecological manifestation of eutrophication through which the lake is undergoing at present.
4-chlorophenol removal from water using graphite and graphene oxides as photocatalysts
Authors: Bustos-Ramírez Karina , Barrera-Díaz Carlos Eduardo , De Icaza-Herrera Miguel , Martínez-Hernández Ana Laura , Natividad-Rangel Reyna , Velasco-Santos Carlos 
Published: April 2015

Abstract
Graphite and graphene oxides have been studied amply in the last decade, due to their diverse properties and possible applications. Recently, their functionality as photocatalytic materials in water splitting was reported. Research in these materials is increasing due to their band gap values around 1.8-4 eV, and therefore, these are comparable with other photocatalysts currently used in heterogeneous photocatalytic processes. Thus, this research reports the photocatalytic effectiveness of graphite oxide (GO) and graphene oxide (GEO) in the degradation of 4-chlorophenol (4-CP) in water. Under the conditions defined for this research, 92 and 97% of 4-CP were degraded with GO and GEO respectively, also 97% of total organic carbon was removed. In addition, by-products of 4-CP that produce a yellow solution obtained only using photolysis are eliminated by photocatalyst process with GO and GEO. The degradation of 4-CP was monitored by UV-Vis spectroscopy, High Performance Liquid Chromatography (HPLC) and Chemical Oxygen Demand (COD). Thus, photocatalytic activity to remove 4-CP from water employing GO and GEO without doping is successfully showed, and therefore, a new gate in research for these materials is opened.
Performance of universal adhesives on bonding to leucite-reinforced ceramic
Authors: Kim Ryan Jin-Young , Woo Jung-Soo , Lee In-Bog , Yi Young-Ah , Hwang Ji-Yun , Seo Deog-Gyu 
Published: April 2015

Abstract

Background
This study aimed to investigate the microshear bond strength of universal bonding adhesives to leucite-reinforced glass-ceramic.

Methods
Leucite-reinforced glass-ceramic blocks were polished and etched with 9.5% hydrofluoric acid for 1 min. The specimens were assigned to one of four groups based on their surface conditioning (n = 16): 1) NC: negative control with no further treatment; 2) SBU: Single Bond Universal (3M ESPE); 3) ABU: ALL-BOND Universal (Bisco); and 4) PC: RelyX Ceramic Primer and Adper Scotchbond Multi-Purpose Adhesive (3M ESPE) as a positive control. RelyX Ultimate resin cement (3M ESPE) was placed on the pretreated ceramic and was light cured. Eight specimens from each group were stored in water for 24 h, and the remaining eight specimens were thermocycled 10,000 times prior to microshear bond strength evaluation. The fractured surfaces were examined by stereomicroscopy and scanning electron microscopy (SEM).

Results
After water storage and thermocycling, the microshear bond strength values decreased in the order of PC > SBU and ABU > NC (P < 0.05). Thermocycling significantly reduced the microshear bond strength, regardless of the surface conditioning used (P < 0.05). Cohesive failure in the ceramic and mixed failure in the ceramic and resin cement were observed in the fractured specimens. The percentage of specimens with cohesive failure after 24 h of water storage was: NC (50%), SBU (75%), ABU (75%), and PC (87%). After thermocycling, the percentage of cohesive failure in NC decreased to 25%; however, yet the percentages of the other groups remained the same.

Conclusions
Although the bond strength between resin and hydrofluoric acid-etched glass ceramic was improved when universal adhesives were used, conventional surface conditioning using a separate silane and adhesive is preferable to a simplified procedure that uses only a universal adhesive for cementation of leucite-reinforced glass-ceramic.
Tweens feel the burn: “salt and ice challenge” burns
Authors: Roussel Lauren O. , Bell Derek E. 
Published: April 2015

Abstract

Purpose: To review our institution’s experience with frostbite injury secondary to “salt and ice challenge” (SIC) participation.

Methods: We conducted a retrospective analysis of intentional freezing burns from 2012 to 2014. Demographics, depth and location of burn, total body surface area of burn, treatment, time to wound healing, length of stay, complications, and motives behind participation were analyzed.

Results: Five patients were seen in the emergency department for intentional freezing burns that resulted from SIC (all females; mean age: 12.3 years; range age: 10.0–13.2 years). Mean total body surface area was 0.408%. Salt and ice was in contact with skin for >10 min for two patients, >20 min for two patients, and an unknown duration for one patient. Complications included pain and burn scar dyschromia. Four patients cited peer pressure and desire to replicate SIC as seen on the Internet as their motivation in attempting the challenge.

Conclusion: SIC has become a popular, self-harming behavior among youths. Increased public education, and provider and parent awareness of SIC are essential to address this public health concern.
Prevalence of victimization, and associated risk factors, impacting youth with disabilities in Vietnam: a population-based study
Authors: Berg Kristin L. , Shiu Cheng-Shi , Nguyen Huong 
Published: April 2015

AbstractLittle research exists on the victimization of youth with disabilities in Asian countries. Yet, developing Asian countries, such as Vietnam, harbor a significant number of youth with disabilities, while services to address their needs often lag behind. The objectives of this study were to: 1) identify the prevalence of reported injuries due to family violence among youth with disabilities in a nationally representative sample of Vietnamese youth, and 2) analyze the relative contribution of disability status and other factors influencing variations in the prevalence of reported injuries. This study employed the 2003 Vietnam Survey Assessment of Vietnamese Youth (VNSAVY), the first nationally representative, population-based survey of 7584 adolescents and young adults in Vietnam. Data collection included face-to-face interviews and self-administered surveys. Weighted bivariate and multiple logistic regressions were used to investigate the relationship among disability, violence, and selected covariates. Results indicated that approximately 14% of Vietnamese youth reported having a disability. Among these youth, approximately 3% reported victimization, in comparison to 2% of able-bodied youth. The odds of youth with disabilities reporting injuries due to family violence remained 50% higher than those without disabilities, controlling for all other variables. Gender and alcohol abuse among family members were also significant risk factors in family violence. Youth with disabilities in developing Asian countries, such as Vietnam, may be vulnerable to physical violence. Preventative programs and services are thus needed to address the unique vulnerabilities of youth with disabilities in developing contexts by screening for victimization experiences and adapting trauma-informed behavioral health services and supports.
Improved diagnosis of mesothelioma by a combination of soluble mesothelin-related peptide and CYFRA 21-1
Authors: Holdenrieder Stefan , Hatz Rudolf , Reinmiedl Judith , Hofmann Karin , Schalhorn Andreas , Stieber Petra 
Published: April 2015

Abstract

Background: Soluble mesothelin-related peptide (sMRP) has shown great potential for malignant mesothelioma detection. However, data on comparison with other cancer and benign diseases as well as with other established lung cancer biomarkers are rare.

Methods: In this study, SMRP was investigated in sera from 1506 individuals including 147 healthy donors, 285 patients with diverse benign diseases and 1074 patients with mesothelioma (n=39) and various malignant tumors (lung, gastrointestinal, gynecological, urological). For differential diagnosis of lung diseases, carcinoembryonic antigen, cytokeratin 19-fragments (CYFRA 21-1), neuron-specific enolase and squamous cell cancer antigen were determined additionally.

Results: Ninety-fifth percentiles of sMRP serum levels in healthy persons were 1.2 nM, in patients with benign diseases between 2.0 and 3.8 nM and in cancer patients between 1.5 and 44.3 nM. Highest values were observed in mesothelioma (median 2.3 nM; 95th percentile 44.3 nM). When differential diagnostic capacity of cancer detection vs. the relevant benign control group was tested, sMRP showed best results for mesothelioma and ovarian cancer with a sensitivity of 45% and 37%, respectively, at 95% specificity. At 100% specificity vs. normal controls, sensitivity for mesothelioma detection was found to be 59% for sMRP, 73% for CYFRA 21-1 and 88% for the combination of both. At 95% specificity vs. all other lung diseases, sensitivity for mesothelioma was 48% for sMRP, 15% for CYFRA 21-1 and 46% for the combination of both.

Conclusions: In summary, SMRP is a valuable serum biomarker that is specific at high concentrations for the detection of malignant mesothelioma. For screening purposes, the combination with CYFRA 21-1 improves the sensitivity at high specificity.
Modelling Plates and Shells by Means of the Rigid Finite Element Method
Authors: Adamiec-Wójcik Iwona , Nowak Andrzej , Wojciech Stanisław 
Published: April 2015

Abstract
The rigid finite element method (RFEM) has been used mainly for modelling systems with beam-like links. This paper deals with modelling of a single set of electrodes consisting of an upper beam with electrodes, which are shells with complicated shapes, and an anvil beam. Discretisation of the whole system, both the beams and the electrodes, is carried out by means of the rigid finite element method. The results of calculations concerned with free vibrations of the plates are compared with those obtained from a commercial package of the finite element method (FEM), while forced vibrations of the set of electrodes are compared with those obtained by means of the hybrid finite element method (HFEM) and experimental measurements obtained on a special test stand.
Crystal structure of 2-(benzo[d][1,3]dioxol-5-yl)-3-benzoylcyclopropane- 1,1-dicarbonitrile, C19H12N2O3
Authors: Yanping Yi 
Published: April 2015

Abstract C19H12N2O3, monoclinic, C2/c (no. 15), a = 19.7091(7) Å, b = 12.0956(7) Å, c = 15.9463(8) Å, β = 123.038(2)°, V = 3186.9 Å3, Z = 8, Rgt(F) = 0.0483, wRref(F2) = 0.1428, T = 296 K.
Half a century of research on diatoms in athalassic habitats in central Poland
Authors: Żelazna-Wieczorek Joanna , Olszyński Rafał M. , Nowicka-Krawczyk Paulina 
Published: April 2015

Abstract
Part of the geology in the Łódź province was formed during the Upper Permian period when rich Zechstein salt was deposited. Groundwater drains the deposits and flows out in the village of Pełczyska, creating a unique hydrogeological site in Central Poland. An inland, athalassic ecosystem can be a reference site for halophile microflora. The outflow with surrounding marshes has been an algological research site since 1964.
The research reveals changes recorded in diatom assemblages from athalassic habitats, characterized by a wide range of salinity levels, and verifies the tolerance of taxa to salinity. The comparative analysis was based on the diatom material sampled in 1964-1965, 1992-1994 and on recently collected samples.
The analysis revealed the temporal change in assemblages caused by a change in the chloride concentration, and the spatial change from one to another habitat type, characterized by varying salinity levels. The halophilic species in the studied habitats included e.g. Halamphora dominici, H. tenerrima, Navicula digitoconvergens, N. meulemansii, Staurophora salina. The analysis of changes allowed the verification of the species’ requirements and tolerance range to the salinity factor. Therefore, in the case of Fragilaria famelica and Halamphora sydowii, we propose a change in the halobion system classification.
Anthropogenic impact on river basins: temporal evolution of sediment classes and accumulation rates in the northern Tyrrhenian Sea, Italy
Authors: Scanu Sergio , Paladini de Mendoza Francesco , Piazzolla Daniele , Marcelli Marco 
Published: April 2015

Abstract
In this study, sedimentological and geochronological data from sections of a core (GRT50) collected in the Northern Latium coastal area were compared to data on pluviometric (rainfall) trends, river flows and the temporal evolution of human interventions in the three most important hydrographic basins (Mignone, Marta and Fiora) of this coastal area. The statistical analysis of pluviometric trends identified variations due to a decreasing trend in the Fiora river basin, whereas in the two other locations the decrease was not so significant. Data from the sedimentological analysis of the core confirmed a progressive decrease in the sandy component, which declined from about 30% to the current level of 7% over the last 36 years. There was no significant variation in the sediment mass accumulation rates (MAR), which were characterized by an almost cyclic trend that was probably determined by the most intense floods in the study area. The results revealed that the variations caused by the fluvial processes have affected the water runoff of the Fiora River, and that the consequent decrease in the sand production has been responsible for the recession of beaches in the coastal area between Tarquinia and Montalto di Castro.
Long-term changes in the dynamics and structure of cyanobacteria in Koronowo Reservoir
Authors: Wiśniewska Marzenna , Paczuska Bogna 
Published: April 2015

Abstract
The Koronowo Reservoir (16.6 km2) is located in the lower reaches of the Brda River, in the Kujawy-Pomerania Province, 20 km from Bydgoszcz near the town of Koronowo, hence the name of the reservoir. The reservoir was built in the 1960s and started from damming the waters of the Brda River by a ca. 20 m high earth dam in the village of Pieczyska. This reservoir is used mainly for water retention and production of electric energy in the hydroelectric power station; in addition, it plays a significant recreational function. In terms of the latter function, the spread of cyanobacteria is a serious problem. The aim of the study was to assess longterm changes in the structure of cyanobacteria in waters of the Koronowo Reservoir. The results from 1996, 2008, 2011 and 2013 were compared. As evidenced by the analysis of the phytoplankton composition in the Koronowo Reservoir in terms of functional groups, especially the occurrence of dominant and subdominant species from the groups P, H1, S1, LM, J, G and W2, the waters of the reservoir can be classified as eutrophic, potentially evolving towards the hypertrophic conditions. The HPLC analysis of cyanobacterial toxins revealed the presence of microcystins at two sites of the water body. The species structure, the distribution and the dominance of specific species of cyanobacteria is recurrent over the 17 years; the following species form algal blooms: Aphanizomenon flos-aquae (L.) Ralfs et Bornet et Flahault and Microcystis aeruginosa (Kütz.) Kützing.
Spectrum and Green’s Function of a Many-Interval Sturm–Liouville Problem
Authors: Aydemir Kadriye , Mukhtarov Oktay Sh. 
Published: April 2015

Abstract
This article considers a Sturm–Liouville-type problem on a finite number disjoint intervals together with transmission conditions at the points of interaction. We introduce a new operator-theoretic formulation in such a way that the problem under consideration can be interpreted as a spectral problem for a suitable self-adjoint operator. We investigate some principal properties of eigenvalues, eigenfunctions, and resolvent operator. Particularly, by applying Green’s function method, it is shown that the problem has only point spectrum, and the set of eigenfunctions form a basis of the adequate Hilbert space.
Projection-Specific Characteristics of Retinal Input to the Brain
Authors: Gauvain Gregory , Murphy Gabe J. 
Published: April 2015

The brain receives information about the direction of object motion from several types of retinal ganglion cells (RGCs). On-Off direction-selective (DS) RGCs respond preferentially to stimuli moving quickly in one of four directions and provide a significant (but difficult to quantify) fraction of RGC input to the SC. On DS RGCs, in comparison, respond preferentially to stimuli moving slowly in one of three directions and are thought to only target retinorecipient nuclei comprising the accessory optic system, e.g., the medial terminal nucleus (MTN).To determine the fraction of SC-projecting RGCs that exhibit direction selectivity, and the specificity with which On-Off and On DS RGCs target retinorecipient areas, we performed optical and electrophysiological recordings from RGCs retrogradely labeled from the mouse SC and MTN. We found, surprisingly, that both On-Off and On DS RGCs innervate the SC; collectively they constitute nearly 40% of SC-projecting RGCs. In comparison, only On DS RGCs project to the MTN. Subsequent experiments revealed that individual On DS RGCs innervate either the SC or MTN and exhibit robust projection-specific differences in somatodendritic morphology, cellular excitability, and light-evoked activity; several projection-specific differences in the output of On DS RGCs correspond closely to differences in excitatory synaptic input the cells receive. Our results reveal a robust projection of On DS RGCs to the SC, projection-specific differences in the response properties of On DS RGCs, and biophysical and synaptic mechanisms that underlie these functional differences.
Comparative Effectiveness of Mitoxantrone Plus Prednisone Versus Prednisone Alone in Metastatic Castrate-Resistant Prostate Cancer After Docetaxel Failure
Authors: Green Angela K. , Corty Robert W. , Wood William A. , Meeneghan Mathew , Reeder-Hayes Katherine E. , Basch Ethan , Milowsky Matthew I. , Dusetzina Stacie B. 
Published: April 2015

Abstract

Background.
Mitoxantrone was approved for use in metastatic castrate-resistant prostate cancer (mCRPC) based on pain palliation without observed survival benefit in a small phase III trial in 1996. To re-evaluate for possible survival benefits in a larger contemporary sample and to demonstrate analytic uses of the newly available Project Data Sphere online resource, we used data from control arms of completed clinical trials to compare survival and toxicity among patients with postdocetaxel mCRPC treated with mitoxantrone and prednisone.

Patients and Methods.
Control arm data from two phase III randomized control trials, SUN 1120 and TROPIC, were used to examine the efficacy of mitoxantrone plus prednisone (n = 305) versus prednisone alone (n = 257) among patients with postdocetaxel mCRPC. Propensity score matching was used to balance patient characteristics between the separate trials, conditioned on age and key prognostic variables of survival. The primary outcome was overall survival. Secondary endpoints evaluated safety.

Results.
Median survival was similar among patients receiving mitoxantrone plus prednisone versus prednisone alone (385 days vs. 336 days; deceleration factor = 0.04; 95% confidence interval: −0.12 to 0.22). Prevalence of several any-grade toxicity, including fatigue, back pain, and peripheral neuropathy, was increased among patients who received mitoxantrone.

Conclusion.
There was no significant survival benefit for mitoxantrone plus prednisone over prednisone alone among men with mCRPC after docetaxel therapy. This finding is consistent with prior studies showing no survival advantage with mitoxantrone in the predocetaxel setting. Furthermore, our data suggest that mitoxantrone may be associated with increased toxicity compared with prednisone alone.