bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cancer health awareness through screening and education: A community approach to healthy equity
Authors: Vernon Marlo , Coughlin Steven S. , Tingen Martha , Jones Samantha , Heboyan Vahe 
Published: June 2024

AbstractBackgroundThe Cancer Health Awareness through screeNinG and Education (CHANGE) initiative delivers cancer awareness education with an emphasis on modifiable risk factors and navigation to screening for prostate, breast, and colorectal cancers to residents of public housing communities who experience significant negative social determinants of health.MethodsResidents of five communities participated. Community advisory board members were recruited and provided feedback to local environmental change projects, recruitment, and community engagement at each site. At each site, four education sessions were provided by trained facilitators on cancer risk factors and etiology, racial disparities, eligibility for cancer screening, and participation in clinical trials. Attendance, knowledge, attitudes and beliefs about cancer, and height, weight, and waist circumference were measured at baseline and 1‐week post‐CHANGE sessions.Results90 residents (60% 65 and older years old, 33% male, 60% High School education, 93% AA) participated in the program. 95% completed post‐intervention evaluation. Participants were eligible for breast (n = 12), prostate (n = 15), and colorectal screening (n = 25) based on American Cancer Society guidelines, and 22 for tobacco cessation; 21 participants accepted navigation assistance for these services. At post‐test, participants significantly increased in knowledge and behaviors around obesity/overweight risk for cancer, nutrition, and physical activity. Colorectal, prostate, and breast cancer knowledge scores also increased, but were not significant.ConclusionsCHANGE participants demonstrated improved health knowledge and intentions to improve their modifiable health behaviors. Participants reported being motivated and confident in seeking preventive care and satisfaction with community engagement efforts. Replication of this project in similar communities may improve knowledge and health equity among underserved populations.
Tobacco quitline staffs' knowledge and attitudes about connecting quitline callers to lung cancer screening educational materials
Authors: Tan Naomi Q. P. , Volk Robert J. , Leal Viola B. , Lettieri Jessica S. , Bailey Linda A. , Ylioja Thomas , Celestino Paula , Lowenstein Lisa M. 
Published: June 2024

AbstractObjectiveTo evaluate the impact of training quitline staff in lung cancer screening (LCS) on knowledge and attitudes towards connecting quitline callers to LCS educational materials.MethodsWe conducted a pre‐post evaluation within a larger implementation project in the U.S. to support LCS among quitline callers. From July 2020 to June 2021, staff from four quitline service providers completed surveys before and after training on LCS knowledge. After training, staff completed the acceptability of intervention measure, intervention appropriateness measure, and feasibility of the intervention measure.ResultsA total of 245 staff completed the initial demographic survey (analytic sample), 130 completed the pre‐training survey, and 225 completed the post‐training survey. Staff were on average 47.4 years old and 76.7% were female. LCS knowledge improved after the training (n = 120, mean difference = +26.5%, 95% CI 21.6, 31.4, p < 0.001). Overall, staff felt that connecting quitline callers to LCS education materials was acceptable (M = 4.0, SD = 0.8), appropriate (M = 4.1, SD = 0.7), and feasible (M = 4.0, SD = 0.7).ConclusionsReceiving training about LCS eligibility and the benefits and harms of screening improved LCS knowledge among quitline staff. Quitline staff found that connecting callers with LCS educational materials is acceptable, appropriate, and feasible, and aligned with their primary mission.
Perceptions of virtual versus in‐person recovery meetings: A cross‐sectional survey of Oxford House residents
Authors: Bobak Ted J. , Wilson Daniel , Bell Justin S. , Jason Leonard A. 
Published: June 2024

AbstractThis study investigates shifts in the modality of addiction recovery communities from person‐to‐person interactions to virtual platforms in the context of the coronavirus disease of 2019 (COVID‐19) pandemic. Our study involves members of the Oxford House recovery homes (n = 284), a major network of recovery‐supportive housing in the United States and abroad. Many residents participate in 12‐step meetings during their stay, traditionally conducted in‐person, but due to physical distancing regulations, many of these meetings transitioned to virtual platforms. We collected cross‐sectional survey data focusing on user perceptions of virtual 12‐step meetings in terms of accessibility, cost, convenience, support network strength and recovery network quality. Our study found significant differences in perceptions among different demographic groups, suggesting challenges in transitioning recovery support to online platforms. Notably, participants aged 46 and older showed a greater propensity to use online recovery forums and found online meetings convenient. Non‐White individuals and women demonstrated a more favourable perception of online meetings—a trend that also held true among those with at least some college education. Furthermore, the results show that those who initiated their recovery prior to the COVID‐19 lockdown viewed online methods more favourably, particularly in terms of accessibility and cost. Our data also revealed that participants who were categorically involved in 12‐step recovery (Alcoholics Anonymous/Narcotics Anonymous) demonstrated a more positive perception of online methods in terms of the strength of social networks and social support quality, despite some resistance to virtual transition and maintaining focus. Further research is needed to understand these nuanced impacts and develop strategies to enhance the effectiveness of online recovery meetings.
Accessing Active Fragments for Drug Discovery Utilising Nitroreductase Biocatalysis
Authors: Holder Lauren , Yuce Eda , Oriomah Gabriel , Jenkins Aimee‐Page , Reynisson Jóhannes , Winter Anja , Cosgrove Sebastian C. 
Published: June 2024

AbstractBiocatalysis has played a limited role in the early stages of drug discovery. This is often attributed to the limited substrate scope of enzymes not affording access to vast areas of novel chemical space. Here, we have shown a promiscuous nitroreductase enzyme (NR‐55) can be used to produce a panel of functionalised anilines from a diverse panel of aryl nitro starting materials. After screening on analytical scale, we show that sixteen substrates could be scaled to 1 mmol scale, with several poly‐functional anilines afforded with ease under the standard conditions. The aniline products were also screened for activity against several cell lines of interest, with modest activity observed for one compound. This study demonstrates the potential for nitroreductase biocatalysis to provide access to functional fragments under benign conditions.
Vaginal artery pseudoaneurysm after a hysterectomy: A case report and review of the literature
Authors: Zabihi Fariba , Moeindarbari Somayeh , Khoroushi Farzaneh , Mishan Mohammad , Ravankhah Moghaddam Khosrow 
Published: June 2024

Key clinical messageThis was the first report of a pseudoaneurysm in a vaginal artery after hysterectomy, unlike other published studies that were of pseudoaneurysms in uterine or vaginal arteries after delivery.AbstractA 51‐year‐old woman presented with massive vaginal bleeding 7 days after a hysterectomy, which caused hemoglobin to drop. The patient was suspicious of having a vaginal artery pseudoaneurysm according to the sonography. Her bleeding was stopped after the ligation of her left internal iliac artery.
Paradoxical air embolism in patients undergoing hysteroscopic surgery for cesarean scar pregnancy: A case report and review of the literatures
Authors: Amirkhanloo Fatemeh , Haddadi Mohammad , Ebrahimi Mahbod 
Published: June 2024

Key Clinical MessageCesarean scar pregnancy cases who undergo hysteroscopic suction aspiration could be at higher risk of air emboli due to dilated, low‐resistant, high‐velocity blood vessels.
Exploring Mercosur‐EU interregionalism: A multifaceted analysis of its past, present and future functions and dynamics
Authors: Alvarez María V. 
Published: June 2024

AbstractThis article provides an analysis of the relationship between the Southern Common Market (Mercosur) and the European Union (EU) focusing on its purposes and functions, by exploring the literature on interregionalism through the perspectives of three distinct schools of thought: neorealism, neoliberal institutionalism and constructivism. Considering the functions theoretically fed by these theories behind interregional relations‐balancing, institution‐building and collective identity‐building‐, the paper attempts at providing a comprehensive understanding of the factors influencing the past and current purposes and functions of Mercosur‐EU relations and holds the potential to anticipate future trends. Our central argument underscores the enduring relevance of the setting of rules and norms and the focus on material gains in shaping the core of the relationship, particularly regarding the trade agreement, while the ideational function of sharing collective identity and values has experienced certain erosion. Nevertheless, increasingly crucial will be the geopolitical purpose, concerning balancing and counterbalancing external actors, given the current era of geopolitical upheaval where binary narratives fall short. We are not concerned with forecasting the future of the relationship as a whole; instead, we aim to analyse which functions will hold greater significance.
A Novel Fluorescent Gemcitabine Prodrug That Follows a Nucleoside Transporter‐Independent Internalization and Bears Enhanced Therapeutic Efficacy With Respect to Gemcitabine
Authors: Vrettos Eirinaios Ι. , Kyrkou Stavroula G. , Zoi Vasiliki , Giannakopoulou Maria , Chatziathanasiadou Maria V. , Kanaki Zoi , Agalou Adamantia , Bistas Vasileios‐Panagiotis , Kougioumtzi Anastasia , Karampelas Theodoros , Diamantis Dimitrios A. , Murphy Carol , Beis Dimitris , Klinakis Apostolos , Tamvakopoulos Constantin , Kyritsis Athanasios P. , Alexiou George A. , Tzakos Andreas G. 
Published: June 2024

AbstractThe multiplexity of cancer has rendered it the second leading cause of mortality worldwide and theragnostic prodrugs have gained popularity in recent years as a means of treatment. Theragnostic prodrugs enable the simultaneous diagnosis and therapy of tumors via high‐precision real‐time drug release monitoring. Herein, we report the development of the small theragnostic prodrug GF, based on the nucleoside anticancer agent gemcitabine and the fluorescent dye 5(6)‐carboxyfluorescein. We have successfully demonstrated its efficient internalization in tumor cells, showing localization throughout both the early and late endocytic pathways. Its mechanism of cell internalization was evaluated, confirming its independence from nucleoside transporters. Its cellular localization via confocal microscopy revealed a clathrin‐mediated endocytosis mechanism, distinguishing it from analogous compounds studied previously. Furthermore, GF exhibited stability across various pH values and in human blood plasma. Subsequently, its in vitro cytotoxicity was assessed in three human cancer cell lines (A549, U87 and T98). Additionally, its pharmacokinetic profile in mice was investigated and the consequent drug release was monitored. Finally, its in vivo visualization was accomplished in zebrafish xenotransplantation models and its in vivo efficacy was evaluated in A549 xenografts. The results unveiled an intriguing efficacy profile, positioning GF as a compelling candidate warranting further investigation.
Realizing Color Transitions for Three Copper (I) Cluster Organic‐Inorganic Hybrid Materials by Adjusting Reaction Conditions
Authors: Shao Juan‐Juan , Xue Zhen‐Dong , Chen Wei‐Min , Zhang Yi , Gao Qiang , Chen Li‐Zhuang , Wang Fang‐Ming 
Published: June 2024

AbstractCopper iodide organic‐inorganic hybrid materials have been favored by many researchers in the field of solid‐state lighting (SSL) due to their structural diversity and optical adjustability. In this paper, three isomeric copper iodide cluster hybrid materials, Cu4I6(L)2(1), Cu5I4.5Cl2.5(L)2(2) and Cu5I7(L)2) (3) (L=1‐(4‐methylpyrimidin‐2‐yl)‐1,4‐diazabicyclo[2.2.2]octan‐1‐ium), were achieved by adjusting the reaction conditions. The crystal color transit from green, yellow to orange and the internal quantum yield (IQY) increase from 57 %–88 %. All three complexes have good thermal stability, good solution processability, and high quantum yield. And origin and mechanism of luminescence of complexes were further studied. This study can provide ideas and theoretical basis for the regulation of cuprous iodide cluster luminescent materials.
Electrochemical Biosensors for Blood‐Borne Viruses Detection: A Review
Authors: Ketabi Kiana , Mohammadinejad Arash , Soleimanjahi Hoorieh , Rezayi Majid , Meshkat Zahra 
Published: June 2024

AbstractThis review article discusses the advancements in electrochemical biosensors for detecting blood‐borne viruses. Infections like HBV, HCV, HIV, and HTLV transmitted through blood can be life‐threatening and have significant impact on both the health and social life. Therefore, timely diagnosis of these infections is crucial. Various effective diagnostic methods have been developed to detect these infections. The combination of nanotechnology and biology has led to creation of new diagnostic techniques using electrodes to detect microorganisms. This review aims to summarize recent studies on the performance of electrochemical biosensors for detecting blood‐borne viruses in the last five years, comparing their characteristics, limits of detection, and other relevant parameters.
A many objective based feature selection model for software defect prediction
Authors: Mao Qi , Zhang Jingbo , Zhao Tianhao , Cai Xingjuan 
Published: June 2024

SummaryGiven the escalating magnitude and intricacy of software systems, software measurement data often contains irrelevant and redundant features, resulting in significant resource and storage requirements for software defect prediction (SDP). Feature selection (FS) has a vital impact on the initial data preparation phase of SDP. Nonetheless, existing FS methods suffer from issues such as insignificant dimensionality reduction, low accuracy in classifying chosen optimal feature sets, and neglect of complex interactions and dependencies between defect data and features as well as between features and classes. To tackle the aforementioned problems, this paper proposes a many‐objective SDPFS (MOSDPFS) model and the binary many‐objective PSO algorithm with adaptive enhanced selection strategy (BMaOPSO‐AR2) is proposed within this paper. MOSDPFS selects F1 score, the number of features within subsets, and correlation and redundancy measures based on mutual information (MI) as optimization objectives. BMaOPSO‐AR2 constructs a binary version of MaOPSO using transfer functions specifically for binary classification. Adaptive update formulas and the introduction of the R2 indicator are employed to augment the variety and convergence of algorithm. Additionally, performance of MOSDPFS and BMaOPSO‐AR2 are tested on the NASA‐MDP and PROMISE datasets. Numerical results prove that a proposed model and algorithm effectively reduces feature count while enhancing predictive accuracy and minimizing model complexity.
A New Biphenol‐bis(polyazacyclophane) Receptor with Unusual Photophysical Properties Towards Zn2+
Authors: Mancini Luca , Inclán Mario , Paderni Daniele , Giorgi Luca , Formica Mauro , García‐España Enrique , Fusi. Vieri 
Published: June 2024

AbstractThe new ligand 3,3′‐bis(((2‐(3,6,9‐triaza‐1(2,6)‐pyridinacyclodecaphane‐6‐yl)ethyl)amino)methyl)‐[1,1′‐biphenyl]‐2,2′‐diol (L) has been synthesized and characterized. It contains two pyridinacyclophane macrocycles spaced by a 2,2’‐biphenol moiety. The acid‐base behaviour of L as well as its binding properties towards Zn2+ ion have been investigated. This work is inserted in the field of fluorescent ditopic receptors, formed by two polyamines spaced by a aromatic fragments. This ligand represents a new example of a peculiar case of polyamine fluorescent receptor in which the interaction with Zn2+ is translated into a deactivation of the emission. Enough data to describe and explain this unusual behaviour was obtained through potentiometric, UV‐Vis, fluorescence and NMR titrations as well as theoretical calculations. This studies have shown that the metal cation is indirectly affecting the emission favouring a conformation in which the fluorophore is at stacking distance from the electron poor pyridine moieties. This gives rise to an oxidative photoinduced electron transfer from the excited state of the fluorophore to the electron‐poor Zn2+ coordined pyridine.
The Independent Contribution of Positive and Negative Metacognitions About Smoking to Urge to Smoke, Withdrawal Symptoms and Dependence in Smoking‐Dependent Men
Authors: Khosravani Vahid , Nikčević Ana V. , Spada Marcantonio M. , Samimi Ardestani Seyed Mehdi , Najafi Mahmoud 
Published: June 2024

ABSTRACTPrevious research has indicated that various factors, such as psychological distress, distress intolerance, anhedonia, impulsivity and smoking metacognitions, have been individually linked to the urge to smoke, withdrawal symptoms and dependence. However, these factors have not been collectively examined to determine whether smoking metacognitions independently and significantly contribute to these outcomes. Therefore, the aim of this study was to investigate the impact of distress intolerance, anhedonia, impulsivity and smoking metacognitions on the urge to smoke, withdrawal symptoms and dependency in men who are dependent on smoking. A total of 300 smoking‐dependent men completed psychological scales and smoking‐related measures. The findings of the study indicated that positive metacognitions about emotion regulation significantly predicted the urge to smoke, even when accounting for other significant predictors such as the number of daily cigarettes smoked, psychological distress, anhedonia and impulsivity. Furthermore, positive metacognitions about cognitive regulation were found to be a significant predictor of withdrawal symptoms, independent of other significant predictors such as psychological distress and the urge to smoke. Smoking dependence was predicted by negative metacognitions about uncontrollability beyond other significant predictors, including the number of daily cigarettes smoked and distress intolerance. These results highlight the role of metacognitions about smoking in both short‐ and long‐term clinical outcomes related to smoking. Consequently, addressing such beliefs during treatment for smoking dependence should be an important therapeutic goal.
Impact of cell lysis treatment before saliva metagenomic DNA extraction on the oral microbiome and the associated resistome
Authors: Tansirichaiya Supathep , Songsomboon Kittikun , Chaianant Nichamon , Lertsivawinyu Wasawat , Al‐Haroni Mohammed 
Published: June 2024

AbstractObjectivesThe human oral microbiome, a complex ecosystem linked to oral and systemic health, harbors a diverse array of microbial populations, including antimicrobial resistance genes (ARGs). As a critical component of the One Health approach to tackle antibiotic resistance, comprehending the oral resistome's composition and diversity is imperative. The objective of this study was to investigate the impact of chemical cell lysis treatment using MetaPolyzyme on the detectability of the oral microbiome, resistome, and DNA quality and quantity.Materials and MethodsSaliva samples were collected from five healthy individuals, and each of the samples was subjected to DNA extraction with and without the treatment with MetaPolyzyme. Through metagenomic sequencing, we analyzed, assessed, and compared the microbial composition, resistome, and DNA characteristics between both groups of extracted DNA.ResultsOur study revealed that MetaPolyzyme treatment led to significant shifts in the detectability of microbial composition, favoring Gram‐positive bacteria, notably Streptococcus, over Gram‐negative counterparts. Moreover, the MetaPolyzyme treatment also resulted in a distinct change in ARG distribution. This shift was characterized by an elevated proportion of ARGs linked to fluoroquinolones and efflux pumps, coupled with a reduction in the prevalence of tetracycline and β‐lactam resistance genes when compared with the nontreated group. Alpha diversity analysis demonstrated altered species and ARG distribution without affecting overall diversity, while beta diversity analysis confirmed significant differences in the taxonomical composition and oral resistome between treated and nontreated groups.ConclusionsThese findings underscore the critical role of cell lysis treatment in optimizing oral metagenomic studies and enhance our understanding of the oral resistome's dynamics in the context of antimicrobial resistance.
A Facile Method to Transform Pickled Olive Wastes Into Sulfur‐Doped Carbon for Sodium‐Ion Battery Electrode
Authors: Medina Alejandro , Alcántara Ricardo , Lavela Pedro , Tirado José L. 
Published: June 2024

AbstractThis work provides a novel, low‐cost, and effective method to prepare disordered carbon materials for advanced sodium‐ion batteries using biomass. A large amount of olive stone waste is yearly produced in the world, and it could be re‐used for fine applications other than fuel for heat production. After treatment with sulfuric acid solution and carbonization process, wastes of olive stone are efficiently transformed into optimized carbon electrode material. XRD, XRF and XPS, electron microscopy, and physical gas adsorption are used for the compositional, microstructural, and textural characterization of the carbons. During the synthesis, impurities are removed, C−S links are formed and micropores pores are created. Sulfuric acid acts like S‐dopant. The latent pores, or pores closed to nitrogen, can be found using CO2 adsorption, and are very suitable for accommodation for sodium. The results reveal that the reversible capacity is raised from ca. 200 mAh g−1 to ca. 250 mAh g−1 for the carbon obtained through treatment with sulfuric acid. The improved electrochemistry is the result of the s‐doping and the porosity.
High PSR capacitor‐less LDO with adaptive bulk‐driven feedforward technique
Authors: Lin Changhong , Chen Zhijian , Tang Xian , Lin Xiaoling , Zheng Yanqi 
Published: June 2024

AbstractThis article presents a capacitor‐less low dropout (LDO) regulator with a high power supply rejection (PSR) for system‐on‐chip (SoC) applications. With the proposed adaptive bulk‐driven feedforward (ABDFF) technique, in which the ripples are injected adaptively to the bulk of power transistor, the LDO maintains a steady PSR enhancement in wide load conditions, and a lower quiescent current and faster load transient response are realized. Post‐layout simulation results show that the proposed LDO regulator achieves −75‐dB PSR at 1 MHz from 1 to 100 mA and 60‐fs figure of merit (FoM) with a 100‐pF load capacitor.