bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reflections on science gateways sustainability through the business model canvas: case study of a neuroscience gateway
Authors: Shahand S. , van Duffelen J. , Olabarriaga S. D. 
Published: June 2015

SummaryThe sustainability of science gateways has been a topic of active discussion because they have been created and supported in the context of temporary research and infrastructure projects. As successful projects come to an end, it is necessary to find (new) models to secure continuous exploitation of products generated by these projects. Taking this step requires business considerations that are not trivial to do from the role of a researcher. This paper presents our experiences in adopting a methodology from lean business development, the Business Model Canvas (BMC). This methodology enables structured reflection upon the business model and facilitates exploring alternative ones (pivoting). We have applied the BMC to one of the science gateways designed, developed, and operated by the Academic Medical Center (AMC) e‐Science group: the AMC Computational Neuroscience Gateway. The current gateway BMC is explained in the paper and used as basis for a reflection to improve its sustainability. Alternative business models are given as examples of BMC iteration or pivots. This exercise helped us to structure the various aspects to be considered when designing or reflecting upon the business model of our gateway. It also facilitated the visualization of the complete business picture and helps the reflection about improvements in the business model toward sustainability. We believe that this methodology could be valuable also for the reflection about sustainability of other science gateways that are growing from academic groups that do not have business training. Copyright © 2015 John Wiley & Sons, Ltd.
CLORIFI: software vulnerability discovery using code clone verification
Authors: Li Hongzhe , Kwon Hyuckmin , Kwon Jonghoon , Lee Heejo 
Published: June 2015

SummarySoftware vulnerability has long been considered an important threat to the system safety. A vulnerability is often reproduced because of the frequent code reuse by programmers. Security patches are usually not propagated to all code clones; however, they could be leveraged to discover unknown vulnerabilities. Static code auditing approaches are frequently proposed to scan source codes for security flaws; unfortunately, these approaches generate too many false positives. While dynamic execution analysis methods can precisely report vulnerabilities, they are ineffective in path exploration, which limits them to scale to large programs. With the purpose of detecting vulnerability in a scalable way with more preciseness, in this paper, we propose a novel mechanism, called software vulnerability discovery using Code Clone Verification (CLORIFI), that scalably discovers vulnerabilities in real world programs using code clone verification. In the beginning, we use a fast and scalable syntax‐based way to find code clones in program source codes based on released security patches. Subsequently, code clones are being verified using concolic testing to dramatically decrease the false positives. In addition, we mitigate the path explosion problem by backward sensitive data tracing in concolic execution. Experiments have been conducted with real‐world open‐source projects (recent Linux OS distributions and program packages). As a result, we found 7 real vulnerabilities out of 63 code clones from Ubuntu 14.04 LTS (Canonical, London, UK) and 10 vulnerabilities out of 40 code clones from CentOS 7.0 (The CentOS Project(community contributed)). Furthermore, we confirmed more code clone vulnerabilities in various versions of programs including Rsyslog (Open Source(Original author: Rainer Gerhards)), Apache (Apache Software Foundation, Forest Hill, Maryland, USA) and Firefox (Mozilla Corporation, Mountain View, California, USA). In order to evaluate the effectiveness of vulnerability verification in a systematic way, we also utilized Juliet Test Suite as measurement objects. The results show that CLORIFI achieves 98% accuracy with 0 false positives. Copyright © 2015 John Wiley & Sons, Ltd.
A new certificateless signature with enhanced security and aggregation version
Authors: Deng Jiang , Xu Chunxiang , Wu Huai , Dong Liju 
Published: June 2015

SummaryTo satisfy the applications in certificateless environment, many researchers have been investigating certificateless aggregate signature schemes. Several schemes that are independent with the aggregated numbers are proposed to reduce the computation overhead. In these schemes, the pairing computations that in verification procedure needs are a constant value. Recently, Hou et al. proposed an improved certificateless aggregate signature scheme. They demonstrated the scheme is provably secure in the random oracle model. However, we find that their scheme is insecure in their security model by giving a concrete attack. Then, we propose an improved certificateless signature scheme and use it to construct a new certificateless signature scheme with enhanced security and aggregation. Furthermore, we provide formal security proof of our new scheme. Compared with other four schemes, our enhanced protocol is more suitable for realistic applications. Copyright © 2015 John Wiley & Sons, Ltd.
Parallel multi‐level 2D‐DWT on CUDA GPUs and its application in ring artifact removal
Authors: Zhu Leqing , Zhou Yadong , Zhang Daxing , Wang Dadong , Wang Huiyan , Wang Xun 
Published: June 2015

SummaryThis paper presented two schemes of parallel 2D discrete wavelet transform (DWT) on Compute Unified Device Architecture graphics processing units. For the first scheme, the image and filter are transformed to spectral domain by using Fast Fourier Transformation (FFT), multiplied and then transformed back to space domain by using inverse FFT. For the second scheme, the image pixels are convolved directly with filters. Because there is no data relevance, the convolution for data points on different positions could be executed concurrently. To reduce data transfer, the boundary extension and down‐sampling are processed during data loading stage, and transposing is completed implicitly during data storage. A similar skill is adopted when parallelizing inverse 2D DWT. To further speed up the data access, the filter coefficients are stored in the constant memory. We have parallelized the 2D DWT for dozens of wavelet types and achieved a speedup factor of over 380 times compared with that of its CPU version. We applied the parallel 2D DWT in a ring artifact removal procedure; the executing speed was accelerated near 200 times compared with its CPU version. The experimental results showed that the proposed parallel 2D DWT on graphics processing units can significantly improve the performance for a wide variety of wavelet types and is promising for various applications. Copyright © 2015 John Wiley & Sons, Ltd.
Worm propagation model in mobile network
Authors: Chen Zhide , Wang Meng , Xu Li , Wu Wei 
Published: June 2015

SummaryWith the popularity of mobile smart devices and functional diversification, the infection ways of mobile smartphones worm also become diverse. In mobile networks, mobile devices are suffering from the threat of worms all the time. Once the worm outbreaks, it will bring huge losses to mobile phone users and mobile network operators. Researches on mobile worm propagation model allow us to control and detect potential worm threat, according to the characteristics of worm's outbreak. In the paper, we put forward a worm propagation model based on the mobile network environment. After analyzing the model, we then give the simulation for controlling factors affecting worm propagation. This model allows us to have a certain understanding for the spread on the size and speed of the mobile worm and provide effective methods to control the spread of the mobile worm. Copyright © 2015 John Wiley & Sons, Ltd.
Mindfulness‐based prevention for eating disorders: A school‐based cluster randomized controlled study
Authors: Atkinson Melissa J. , Wade Tracey D. 
Published: June 2015

ABSTRACTObjectiveSuccessful prevention of eating disorders represents an important goal due to damaging long‐term impacts on health and well‐being, modest treatment outcomes, and low treatment seeking among individuals at risk. Mindfulness‐based approaches have received early support in the treatment of eating disorders, but have not been evaluated as a prevention strategy. This study aimed to assess the feasibility, acceptability, and efficacy of a novel mindfulness‐based intervention for reducing the risk of eating disorders among adolescent females, under both optimal (trained facilitator) and task‐shifted (non‐expert facilitator) conditions.MethodA school‐based cluster randomized controlled trial was conducted in which 19 classes of adolescent girls (N = 347) were allocated to a three‐session mindfulness‐based intervention, dissonance‐based intervention, or classes as usual control. A subset of classes (N =156) receiving expert facilitation were analyzed separately as a proxy for delivery under optimal conditions.ResultsTask‐shifted facilitation showed no significant intervention effects across outcomes. Under optimal facilitation, students receiving mindfulness demonstrated significant reductions in weight and shape concern, dietary restraint, thin‐ideal internalization, eating disorder symptoms, and psychosocial impairment relative to control by 6‐month follow‐up. Students receiving dissonance showed significant reductions in socio‐cultural pressures. There were no statistically significant differences between the two interventions. Moderate intervention acceptability was reported by both students and teaching staff.DiscussionFindings show promise for the application of mindfulness in the prevention of eating disorders; however, further work is required to increase both impact and acceptability, and to enable successful outcomes when delivered by less expert providers. © 2015 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:1024–1037).
Synthesis of novel (Z)‐methyl‐12‐aminooctadec‐9‐enoate‐based phenolipids as potential antioxidants and chemotherapeutic agents
Authors: Yarra Mohini , Kaki Shiva Shanker , Prasad Rachapudi B. N. , Mallampalli Karuna S. L. , Yedla Poornachandra , Chityala Ganesh Kumar 
Published: June 2015

A series of novel phenolipids were synthesized by coupling (Z)‐methyl‐12‐aminooctadec‐9‐enoate with substituted aromatic phenolic acids. The substrate (Z)‐methyl‐12‐aminooctadec‐9‐enoate was synthesized from methyl ricinoleate employing a four‐step procedure. The synthesized phenolipids were thoroughly characterized by FT‐IR, 1H NMR, 13C NMR, ESI‐MS, and HRMS spectral analysis. The in vitro antioxidant activities of synthesized compounds were evaluated by 2, 2‐diphenyl‐1‐picrylhydrazyl radical (DPPH•), superoxide free radical scavenging activity, and lipid peroxidation inhibitory activities. The novel phenolic compounds were compared in terms of antioxidant activity with the commercial antioxidants, namely butylated hydroxy toluene (BHT) and α‐tocopherol as reference compounds. The antioxidant screening data of all the synthesized compounds revealed that DPPH free radical scavenging activity, superoxide, and lipid peroxidation inhibitory activity of caffeic and gallic acid substituted phenolipids exhibited excellent activity as compared to commercial antioxidants, BHT, and α‐tocopherol. The synthesized phenolipids were also evaluated for anticancer activities against four different cancer cell lines namely DU145, HePG2, SKOV3, MDA‐MB‐231. Among these compounds, 7a, 7b, 7d, 7e which were derived from cinnamic acid‐based phenolic acids and 8b which is derived from vanillic acid exhibited good anticancer activity against the tested cell lines.Practical applications: Lipophilization of phenolic acids improves their antioxidant and anticancer properties. The (Z)‐methyl‐12‐aminooctadec‐9‐enoate‐based phenolipids can be exploited in a number of lipophilic antioxidant and anticancer formulations.A panel of (Z)‐methyl‐12‐aminooctadec‐9‐enoate‐based phenolipids are synthesized for the first time from methyl ricinoleate, an unusual fatty acid isolated from castor oil. These compounds were evaluated for antioxidant properties, and gallic and caffeic acid‐based phenolipids exhibited extraordinary properties compared to BHT and α‐tocopherol commercially available antioxidants used in food and pharmaceutical formulations. These compounds were evaluated for anticancer activity for the first time, where these have exhibited good to moderate activity. Hence, (Z)‐methyl‐12‐aminooctadec‐9‐enoate‐based phenolipids can be exploited in a number of lipophilic antioxidant and anticancer formulations.
Fate of polychlorinated biphenyls in a contaminated lake ecosystem: Combining equilibrium passive sampling of sediment and water with total concentration measurements of biota
Authors: Mäenpää Kimmo , Leppänen Matti T. , Figueiredo Kaisa , Mayer Philipp , Gilbert Dorothea , Jahnke Annika , Gil-Allué Carmen , Akkanen Jarkko , Nybom Inna , Herve Sirpa 
Published: June 2015

Abstract

Equilibrium sampling devices can be applied to study and monitor the exposure and fate of hydrophobic organic chemicals on a thermodynamic basis. They can be used to determine freely dissolved concentrations and chemical activity ratios and to predict equilibrium partitioning concentrations of hydrophobic organic chemicals in biota lipids. The authors' aim was to assess the equilibrium status of polychlorinated biphenyls (PCBs) in a contaminated lake ecosystem and along its discharge course using equilibrium sampling devices for measurements in sediment and water and by also analyzing biota. The authors used equilibrium sampling devices (silicone rubber and polyethylene [PE]) to determine freely dissolved concentrations and chemical activities of PCBs in the water column and sediment porewater and calculated for both phases the corresponding equilibrium concentrations and chemical activities in model lipids. Overall, the studied ecosystem appeared to be in disequilibrium for the studied phases: sediment, water, and biota. Chemical activities of PCBs were higher in sediment than in water, which implies that the sediment functioned as a partitioning source of PCBs and that net diffusion occurred from the sediment to the water column. Measured lipid-normalized PCB concentrations in biota were generally below equilibrium lipid concentrations relative to the sediment (CLip⇌Sed) or water (CLip⇌W), indicating that PCB levels in the organisms were below the maximum partitioning levels. The present study shows the application versatility of equilibrium sampling devices in the field and facilitates a thermodynamic understanding of exposure and fate of PCBs in a contaminated lake and its discharge course. Environ Toxicol Chem 2015;34:2463–2474. © 2015 SETAC
UVCB substances: Methodology for structural description and application to fate and hazard assessment
Authors: Dimitrov Sabcho D. , Georgieva Denitsa G. , Pavlov Todor S. , Karakolev Yordan H. , Karamertzanis Panagiotis G. , Rasenberg Mike , Mekenyan Ovanes G. 
Published: June 2015

Abstract

Substances of unknown or variable composition, complex reaction products, or biological materials (UVCBs) have been conventionally described in generic terms. Commonly used substance identifiers are generic names of chemical classes, generic structural formulas, reaction steps, physical–chemical properties, or spectral data. Lack of well-defined structural information has significantly restricted in silico fate and hazard assessment of UVCB substances. A methodology for the structural description of UVCB substances has been developed that allows use of known identifiers for coding, generation, and selection of representative constituents. The developed formats, Generic Simplified Molecular-Input Line-Entry System (G SMILES) and Generic Graph (G Graph), address the need to code, generate, and select representative UVCB constituents; G SMILES is a SMILES-based single line notation coding fixed and variable structural features of UVCBs, whereas G Graph is based on a workflow paradigm that allows generation of constituents coded in G SMILES and end point–specific or nonspecific selection of representative constituents. Structural description of UVCB substances as afforded by the developed methodology is essential for in silico fate and hazard assessment. Data gap filling approaches such as read-across, trend analysis, or quantitative structure–activity relationship modeling can be applied to the generated constituents, and the results can be used to assess the substance as a whole. The methodology also advances the application of category-based data gap filling approaches to UVCB substances. Environ Toxicol Chem 2015;34:2450–2462. © 2015 SETAC
Incompressible multiphase flow and encapsulation simulations using the moment‐of‐fluid method
Authors: Li Guibo , Lian Yongsheng , Guo Yisen , Jemison Matthew , Sussman Mark , Helms Trevor , Arienti Marco 
Published: June 2015

SummaryA moment‐of‐fluid method is presented for computing solutions to incompressible multiphase flows in which the number of materials can be greater than two. In this work, the multimaterial moment‐of‐fluid interface representation technique is applied to simulating surface tension effects at points where three materials meet. The advection terms are solved using a directionally split cell integrated semi‐Lagrangian algorithm, and the projection method is used to evaluate the pressure gradient force term. The underlying computational grid is a dynamic block‐structured adaptive grid. The new method is applied to multiphase problems illustrating contact‐line dynamics, triple junctions, and encapsulation in order to demonstrate its capabilities. Examples are given in two‐dimensional, three‐dimensional axisymmetric (R–Z), and three‐dimensional (X–Y–Z) coordinate systems. Copyright © 2015 John Wiley & Sons, Ltd.
Influence of strip thinning on nutrient outflow concentrations from plantation forested watersheds
Authors: Fukushima Takehiko , Tei Rai , Arai Hiroyuki , Onda Yuichi , Kato Hiroaki , Kawaguchi Shimpei , Gomi Takashi , Dung Bui X. , Nam Sooyoun 
Published: June 2015

AbstractNutrient concentrations in stream water, rainfall, throughfall, stemflow, surface flow and ground water were compared before, during and after strip thinning (intensive 50%) in plantation forested watersheds in Tochigi, Japan. Influences were evaluated comparing four thinning‐applied and two reference basins for 1 year before, 6 months during and 1 year after the thinning. Results show that this strip thinning significantly increased dissolved total phosphorus, total phosphorus and dissolved organic carbon (0.01, 0.04 and 0.53 mg l−1, respectively) during the thinning period and dissolved total nitrogen and total nitrogen (0.34 and 0.46 mg l−1, respectively) after the thinning in stream waters relative to the unthinned basins. The increased phosphorus during thinning indicated ground disturbances by the strip thinning, with a concomitant increase in dissolved organic carbon. Changes in biotic and abiotic conditions resulted in increased nitrogen after the thinning, particularly in the dissolved pool. Changes in hydrological processes due to thinning, for example, a change in flow distributions (less high nutrient stemflow and more low nutrient throughfall) and an increase in water discharge in stream water, possibly weakened the direct influences of thinning on nutrient concentrations. Copyright © 2015 John Wiley & Sons, Ltd.
Metabolic Suppression of a Drug‐Resistant Subpopulation in Cancer Spheroid Cells
Authors: Koshkin Vasilij , Ailles Laurie E. , Liu Geoffrey , Krylov Sergey N. 
Published: June 2015

ABSTRACTInhibition of metabolic features which distinguish cancer cells from their non‐malignant counterparts is a promising approach to cancer treatment. Energy support for drug extrusion in multidrug resistance (MDR) is a potential target for metabolic inhibition. Two major sources of ATP‐based metabolic energy are partial (glycolysis) and complete (mitochondrial oxidative phosphorylation) oxidation of metabolic fuels. In cancer cells, the balance between them tends to be shifted toward glycolysis; this shift is considered to be characteristic of the cancer metabolic phenotype. Numerous earlier studies, conducted with cells cultured in a monolayer (2‐D model), suggested inhibition of glycolytic ATP production as an efficient tool to suppress MDR in cancer cells. Yet, more recent work challenged the appropriateness of the 2‐D model for such studies and suggested that a more clinically relevant approach would utilize a more advanced cellular model such as a 3‐D model. Here, we show that the transition from the 2‐D model (cultured monolayer) to a 3‐D model (cultured spheroids) introduces essential changes into the concept of energetic suppression of MDR. The 3‐D cell organization leads to the formation of a discrete cell subpopulation (not formed in the 2‐D model) with elevated MDR transport capacity. This subpopulation has a specific metabolic phenotype (mixed glycolytic/oxidative MDR support) different from that of cells cultured in the 2‐D model. Finally, the shift to the oxidative phenotype becomes greater when the spheroids are grown under conditions of lactic acidosis that are typical for solid tumors. The potential clinical significance of these findings is discussed. J. Cell. Biochem. 117: 59–65, 2016. © 2015 Wiley Periodicals, Inc.
Lentiviral Vector‐Mediated FoxO1 Overexpression Inhibits Extracellular Matrix Protein Secretion Under High Glucose Conditions in Mesangial Cells
Authors: Guo Feng , Wang Qingzhu , Zhou Yingni , Wu Lina , Ma Xiaojun , Liu Fei , Huang Fengjuan , Qin Guijun 
Published: June 2015

ABSTRACTDiabetic nephropathy is characterized by inordinate secretion of extracellular matrix (ECM) proteins from mesangial cells (MCs), which is tightly associated with excessive activation of TGF‐β signaling. The forkhead transcription factor O1 (FoxO1) protects mesangial cells from hyperglycemia‐induced oxidative stress, which may be involved in ameliorating the redundant secretion of ECM proteins under high glucose conditions. Here, we reported that high glucose elevated the level of p‐Akt to attenuate endogenous FoxO1 bioactivities in MCs, accompanied with decreases in the mRNA expressions of catalase (CAT) and superoxide dismutase 2 (SOD2). Meanwhile, the expressions of major ECM proteins‐FN and Col I‐increased under high glucose conditions, in consistent with the activation of TGF‐β/Smad signaling. By contrast, overexpression of nucleus‐localized FoxO1 (insensitive to Akt phosphorylation) directly up‐regulated the expressions of anti‐oxidative enzymes, accompanied with inactivation of TGF‐β/Smad3 pathway, as well as decreases of extracellular matrix proteins. Moreover, similar to those MCs overexpressed of nucleus‐localized FoxO1 in high glucose conditions, MCs with down‐regulation of FoxO1 by small interference‐RNA under normal glucose conditions showed increased FN level and activated TGF‐β/Smad3 pathway. Our findings link the anti‐oxidative activity of FoxO1 and the TGF‐β‐induced secretion of ECM proteins, indicating the novel role of FoxO1 in protecting MCs under high glucose conditions. J. Cell. Biochem. 117: 74–83, 2016. © 2015 Wiley Periodicals, Inc.