bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effektive Markierung von bioaktiven Peptiden mit PHIP‐Markern zur Steigerung der Empfindlichkeit von NMR‐Signalen
Authors: Sauer Grit , Nasu Daichi , Tietze Daniel , Gutmann Torsten , Englert Simon , Avrutina Olga , Kolmar Harald , Buntkowsky Gerd 
Published: October 2014

AbstractNeuartige, bioaktive Derivate des Sunflower Trypsin Inhibitors‐1 (SFTI‐1), die für die Hyperpolarisation mittels Parawasserstoff‐induzierter Kernspinpolarisation (PHIP) geeignet sind, wurden entwickelt. Die PHIP‐Aktivität dieser Derivate wurde durch den Einbau der Marker L‐Propargylglycin, O‐Propargyl‐L‐tyrosin oder 4‐Pentinsäure erreicht. In wässrigen Lösungen konnten 1H‐NMR‐Signalverstärkungen um bis zu 70 erzielt werden. Eine isolierte räumliche Lage der Dreifachbindung und die Zugänglichkeit des Markers für den Katalysator sind essenziell für den Grad der erreichbaren Signalverstärkung.
Direct Spectroscopic Evidence of Hyperconjugation Unveils the Conformational Landscape of Hydrazides
Authors: Gloaguen Eric , Brenner Valérie , Alauddin Mohammad , Tardivel Benjamin , Mons Michel , Zehnacker‐Rentien Anne , Declerck Valérie , Aitken David J. 
Published: October 2014

AbstractThe stereochemistry of hydrazides makes them especially interesting as building blocks for molecular design. An exhaustive conformational analysis of three model hydrazides was conducted in a conformer‐selective approach by using a combination of high‐level quantum chemistry calculations and vibrational spectroscopy in the gas phase and in solution. The NH stretch frequency was found to be highly sensitive to hyperconjugation, thus making it an efficient probe of the conformation of the neighboring nitrogen atom. This property greatly assisted the identification of the isomers observed experimentally in the conformer pool. A rationalization of the hydrazide conformational landscape is proposed, therefore paving the way for a better characterization of secondary structures in larger systems.
Ag[Fe(CO)5]2+: A Bare Silver Complex with Fe(CO)5 as a Ligand
Authors: Malinowski Przemysław J. , Krossing Ingo 
Published: October 2014

AbstractAttempts to prepare Fe(CO)5+ from Ag[Al(ORF)4] (RF=C(CF3)3) and Fe(CO)5 in CH2Cl2 yielded the first complex of a neutral metal carbonyl bound to a simple metal cation. The Ag[Fe(CO)5]2+ cation consists of two Fe(CO)5 molecules coordinating Ag+ in an almost linear fashion. The ν(CO) modes are blue‐shifted compared to Fe(CO)5, with one band above 2143 cm−1 indicating that back‐bonding is heavily decreased in the Ag[Fe(CO)5]2+ cation.
Auto‐Oxidative Coupling of Glycine Derivatives
Authors: Huo Congde , Yuan Yong , Wu Mingxia , Jia Xiaodong , Wang Xicun , Chen Fengjuan , Tang Jing 
Published: October 2014

AbstractThe unprecedented title reaction between glycine derivatives and indoles, as well as the auto‐oxidative Povarov/aromatization tandem reaction of glycine derivatives with olefins are described. The reactions were performed in the absence of redox‐active catalysts and chemical oxidants under mild reaction conditions. Only simple organic solvents and air (or O2) were required.
Development and validation of a rapid HPLC method for quantitation of SP‐141, a novel pyrido[b]indole anticancer agent, and an initial pharmacokinetic study in mice
Authors: Nag Subhasree , Qin Jiang‐Jiang , Voruganti Sukesh , Wang Ming‐Hai , Sharma Horrick , Patil Shivaputra , Buolamwini John K. , Wang Wei , Zhang Ruiwen 
Published: October 2014

AbstractThere is an increasing interest in targeting the MDM2 oncogene for cancer therapy. SP‐141, a novel designed small molecule MDM2 inhibitor, exerts excellent in vitro and in vivo anticancer activity. To facilitate the preclinical development of this candidate anticancer agent, we have developed an HPLC method for the quantitative analysis of SP‐141. The method was validated to be precise, accurate, and specific, with a linear range of 16.2–32,400 ng/mL in plasma, 16.2–6480 ng/mL in homogenates of brain, heart, liver, kidneys, lungs, muscle and tumor, and 32.4–6480 ng/mL in spleen homogenates. The lower limit of quantification was 16.2 ng/mL in plasma and all the tissue homogenates, except for spleen homogenates, where it was 32.4 ng/mL. The intra‐ and inter‐assay precisions (coefficient of variation) were between 0.86 and 13.39%, and accuracies (relative errors) ranged from −8.50 to 13.92%. The relative recoveries were 85.6–113.38%. SP‐141 was stable in mouse plasma, modestly plasma bound and metabolized by S9 microsomal enzymes. We performed an initial pharmacokinetic study in tumor‐bearing nude mice, demonstrating that SP‐141 has a short half‐life in plasma and wide tissue distribution. In summary, this HPLC method can be used in future preclinical and clinical investigations of SP‐141. Copyright © 2014 John Wiley & Sons, Ltd.
Aplastic anemia associated with systemic lupus erythematosus in children – case report and review of the literature
Authors: van den Akker Machiel , Silverman Earl , Abdelhaleem Mohamed , Kirby‐Allen Melanie 
Published: October 2014

Key Clinical MessageSystemic lupus erythematosus should be included in the differential diagnosis of every adolescent with pancytopenia. An accurate diagnosis with the appropriate therapy is vital and can cause lasting reversal of this condition.
A very rare case of primary meningococcal arthritis in an adult male
Authors: Nihonyanagi Shin , Sunakawa Keisuke , Cui Longzhu , Masaki Tsuguto , Wada Tatsuhiko , Hoshiyama Takayuki , Nakamura Masaki , Takayama Yoko , Kanoh Yuhsaku , Ogawa Akifumi , Shichiri Masayoshi , Hanaki Hideaki 
Published: October 2014

Key Clinical MessageWe report here a very rare case of primary meningococcal arthritis of the knee joint without clinical features associated with meningococcemia, meningitis, or meningococcal complications. The patient suffered from diabetes mellitus and had experienced two episodes of joint trauma. Intravenous infusion of ampicillin/sulbactam for 18 consecutive days was successful.
Interstitial pneumonitis related to rituximab therapy for Waldenström's macroglobulinemia
Authors: Bai Xueyan , Cui Qu , Liu Yuanbo 
Published: October 2014

Key Clinical MessageRituximab‐combined therapeutic regimens have been recommended for treatment of Waldenström's Macroglobulinemia (WM). We report one WM patient who developed interstitial pneumonitis after rituximab therapy.
Semi‐Empirical Model for Limestone Dissolution in Adipic Acid for Wet Flue Gas Desulfurization
Authors: Koech Lawrence , Rutto Hilary , Everson Ray , Neomagus Hein 
Published: October 2014

AbstractWet flue gas desulfurization systems are commonly applied to remove sulfur dioxide by contacting it with limestone in an aqueous phase. The effects of pH, stirring speed, solid‐to‐liquid ratio, acid concentration, and temperature on the dissolution rate of limestone in adipic acid were investigated. The reaction dissolution kinetics was determined by fitting the experimental data into the shrinking core model. The sorbent was characterized at different dissolution periods. An increase in the specific surface area of the sorbent was attributed to formation of portlandite. The experimental data were found to fit the shrinking core model with chemical reaction control. A semi‐empirical model was developed from the experimental data to describe the dissolution kinetics.
Sb‐Triggered β‐to‐α Transition: Solvothermal Synthesis of Metastable α‐Cu2Se
Authors: Jia Feng , Zhang Shu , Zhang Xiaokun , Peng Xiaoli , Zhang Haitao , Xiang Yong 
Published: October 2014

AbstractControl over phase stabilities during synthesis processes is of great importance for both fundamental studies and practical applications. We describe herein a facile strategy for the synthesis of Cu2Se with phase selectivity through a simple solvothermal method. In the presence and absence of SbCl3, monoclinic α‐Cu2Se and cubic β‐Cu2Se can be synthesized, respectively. The formation of α‐Cu2Se requires optimization of the Cu/Se molar ratio in the starting reagents, the reaction temperature, as well as the timing for the addition of SbCl3. Differential scanning calorimetry of the synthesized α‐Cu2Se has shown that a part of it undergoes a phase transition to β‐Cu2Se at 135 °C, and that this phase transition is irreversible on cooling to ambient temperature. Kinetic studies have revealed that in the presence of Sb species the kinetically favored β‐Cu2Se transforms to the thermodynamically favored α‐Cu2Se. In this β‐to‐α phase transition process, the distribution of Cu ions in β‐Cu2Se, as determined by the Cu/Se ratio and temperature, is likely to play a crucial role.
Terpy(Pt–salphen)2 Switchable Luminescent Molecular Tweezers
Authors: Doistau Benjamin , Tron Arnaud , Denisov Sergey A. , Jonusauskas Gediminas , McClenaghan Nathan D. , Gontard Geoffrey , Marvaud Valérie , Hasenknopf Bernold , Vives Guillaume 
Published: October 2014

AbstractThe design and synthesis of switchable molecular tweezers based on a luminescent terpy(Pt‐salphen)2 (1; terpy=terpyridine) complex is reported. Upon metal coordination, the tweezers can switch from an open “W”‐shaped conformation to a closed “U”‐shaped form that is adapted for selective recognition of cations. Closing of the tweezers by metal coordination (M=Zn2+, Cu2+, Pb2+, Fe2+, Hg2+) was monitored by 1H NMR and/or UV/Vis titrations. During the titration, exclusive formation of the 1:1 complex [M(1)] was observed, without appearance of an intermediate 1:2 complex [M(1)2]. The crystallographic structure of the 1:1 complex was obtained with Pb2+ and showed a distorted helical structure. Selective intercalation of Hg2+ cations by the closed “U” form was observed. The tweezers were reopened by selective metal decoordination of the terpyridine ligand by using tris(2‐aminoethyl)amine (tren) as a competitive ligand without modification of the Pt–salphen complex. Detailed photophysical studies were performed on the open and closed tweezers. Structured emission was observed in the open form from the Pt–salphen moieties, with a high quantum yield and a long lifetime. The emission is slightly modified upon closing with 1 equivalent of Zn2+ or Hg2+, whereas a dramatic quenching was obtained upon intercalation of additional Hg2+.
Terminal Alkenes as Versatile Chemical Reporter Groups for Metabolic Oligosaccharide Engineering
Authors: Späte Anne‐Katrin , Schart Verena F. , Schöllkopf Sophie , Niederwieser Andrea , Wittmann Valentin 
Published: October 2014

AbstractThe Diels–Alder reaction with inverse electron demand (DAinv reaction) of 1,2,4,5‐tetrazines with electron rich or strained alkenes was proven to be a bioorthogonal ligation reaction that proceeds fast and with high yields. An important application of the DAinv reaction is metabolic oligosaccharide engineering (MOE) which allows the visualization of glycoconjugates in living cells. In this approach, a sugar derivative bearing a chemical reporter group is metabolically incorporated into cellular glycoconjugates and subsequently derivatized with a probe by means of a bioorthogonal ligation reaction. Here, we investigated a series of new mannosamine and glucosamine derivatives with carbamate‐linked side chains of varying length terminated by alkene groups and their suitability for labeling cell‐surface glycans. Kinetic investigations showed that the reactivity of the alkenes in DAinv reactions increases with growing chain length. When applied to MOE, one of the compounds, peracetylated N‐butenyloxycarbonylmannosamine, was especially well suited for labeling cell‐surface glycans. Obviously, the length of its side chain represents the optimal balance between incorporation efficiency and speed of the labeling reaction. Sialidase treatment of the cells before the bioorthogonal labeling reaction showed that this sugar derivative is attached to the glycans in form of the corresponding sialic acid derivative and not epimerized to another hexosamine derivative to a considerable extent.
A multi‐institution pooled analysis of gastrostomy tube dependence in patients with oropharyngeal cancer treated with definitive intensity‐modulated radiotherapy
Authors: Setton Jeremy , Lee Nancy Y. , Riaz Nadeem , Huang Shao‐Hui , Waldron John , O'Sullivan Brian , Zhang Zhigang , Shi Weij , Rosenthal David I. , Hutcheson Katherine A. , Garden Adam S. 
Published: October 2014

BACKGROUNDSevere swallowing dysfunction necessitating enteral support is a well known late sequela of nonsurgical therapy for oropharyngeal cancer, but its incidence after intensity‐modulated radiotherapy has not been quantified comprehensively outside of small single‐institution series.METHODSThis was a multi‐institution, institutional review board‐approved, retrospective study. Consecutive patients with oropharyngeal squamous cell carcinoma who had received definitive intensity‐modulated radiotherapy from 1998 to 2011 were identified from 3 academic centers.RESULTSIn total, 2315 patients were included. The American Joint Committee on Cancer staging distribution was as follows: stage I, 2.1%; stage II, 4.4%; stage III, 14.7%; and stage IV, 77.3%. Among 1459 patients (63%) who received a gastrostomy tube (g‐tube), placement was prophylactic in 52% and reactive in 48%. Among patients with stage III and IV disease, 58% received concurrent chemotherapy. The median follow‐up was 43.7 months (range, 0.1‐164 months). The g‐tube dependence rate was 7% at 1 year and 3.7% at 2 years. Among 1238 patients with stage III and IV disease who received concurrent chemotherapy, the 1‐year and 2‐year rates of g‐tube dependence were 8.6% and 4.4%, respectively. The 1‐year g‐tube dependence rate was 5% for patients with stage I and II disease; 5.2% for patients with stage III and IV, T1‐T2/N0‐N2 disease; and 10.1% for patients with stage III and IV, T3‐T4 or N3 disease. On multivariate analysis, advanced age (odds ratio [OR], 1.066; P<.001), greater number of smoking pack‐years (OR, 1.008; P=.04), advanced N‐category (OR, 1.13; P=.049), and receipt of cytotoxic chemotherapy (OR, 2.26; P=.02) were predictive of g‐tube dependence at 1 year.CONCLUSIONSThis multi‐institution series of 2315 patients treated at 3 institutions demonstrates that modern nonsurgical therapy for oropharyngeal cancer is associated with a low rate of long‐term g‐tube dependence. Cancer 2015;121:294–301. © 2014 American Cancer Society.
A subthreshold current‐sensing ΣΔ modulator for low‐voltage and low‐power sensor interfaces
Authors: Katic Nikola , Kazi Ibrahim , Tajalli Armin , Schmid Alexandre , Leblebici Yusuf 
Published: October 2014

SummaryA continuous‐time (CT) ΣΔ modulator for sensing and direct analog‐to‐digital conversion of nA‐range (subthreshold) currents is presented in this work. The presented modulator uses a subthreshold technique based on subthreshold source‐coupled logic cells to efficiently convert subthreshold current to digital code without performing current‐to‐voltage conversion. As a benefit of this technique, the current‐sensing CT ΣΔ modulator operates at low voltage and consumes very low power, which makes it convenient for low‐power and low‐voltage current‐mode sensor interfaces. The prototype design is implemented in a 0.18 µm standard complementary metal‐oxide semiconductor technology. The modulator operates with a supply voltage of 0.8 V and consumes 5.43 μW of power at the maximum bandwidth of 20 kHz. The obtainable current‐sensing resolution ranges from effective number of bits (ENOB) = 7.1 bits at a 5 kHz bandwidth to ENOB = 6.5 bits at a 20 kHz bandwidth (ENOB). The obtained power efficiency (peak FoM = 1.5 pJ/conv) outperforms existing current‐mode analog‐to‐digital converter designs and is comparable with the voltage‐mode CT ΣΔ modulators. The modulator generates very low levels of switching noise thanks to CT operation and subthreshold current‐mode circuits that draw a constant subthreshold current from the voltage supply. The presented modulator is used as a readout interface for sensors with current‐mode output in ultra low‐power conditions and is also suitable to perform on‐chip current measurements in power management circuits. Copyright © 2014 John Wiley & Sons, Ltd.
Traffic diversity and code coverage: a preliminary analysis
Authors: Lin Ying‐Dar , Lai Yuan‐Cheng , Lu Chun‐Nan , Hung Jui‐Tsun , Shao Chun‐Pin 
Published: October 2014

SummaryIt is generally assumed that using more diverse traffic to test network devices could achieve larger code coverage. However, how to describe the diversity of traffic traces and the relationship between the traffic diversity and code coverage is still an issue. In this paper, the traffic diversity is defined using the number of packets and the size of the subnets involved, and traces having various diversity are used to evaluate the corresponding code coverage for the programs in a network device. Experiment results show that more number of packets or larger size of network segments can generate larger diversity indices and thus larger code coverage. For Snort, as the number of packets increases from 1 to 10,000,000, representative diversity index and the code coverage can increase from 0 to 0.95 on the basis of Simpson's index and from 19.1% to 32.2%, respectively. As the size of network segments increases, representative diversity index and the code coverage can increase from 0.41 to 0.82 and from 28.2% to 32.2%, respectively. Similar results can be obtained in the case of Linux kernel. If the mappings among different diversity indices and the corresponding code coverage can be built beforehand, the quality of the tests can improved. Copyright © 2014 John Wiley & Sons, Ltd.
Geometry‐based statistical channel model and performance for MIMO antennas
Authors: Zhou Jie , Jiang Hao , Kikuchi Hisakazu 
Published: October 2014

SummaryTo test an adaptive array algorithm in cellular communications, we developed a geometry‐based statistical channel model for radio propagation environments, which provides the statistics of the angle of arrival and time of arrival of the multipath components. This channel model assumes that each multipath component of the propagating signal undergoes only one bounce traveling from the transmitter to the receiver and that scattering objects are located according to Gaussian and exponential spatial distributions, and a new scatterer distribution is proposed as a trade‐off between the outdoor and the indoor propagation environments. Using the channel model, we analyze the effects of directional antennas at the base station on the Doppler spectrum of a mobile station due to its motion and the performance of its MIMO systems. Copyright © 2014 John Wiley & Sons, Ltd.
β‐Lactam Bioconjugates Bearing Luminescent Platinum(II) Tags: Synthesis and Photophysical Characterization
Authors: Soldati Roberto , Aliprandi Alessandro , Mauro Matteo , De Cola Luisa , Giacomini Daria 
Published: October 2014

AbstractTwo novel neutral complexes based on platinum metal ions, a tridentate ligand, and a pyridine bearing a β‐lactam unit have been synthesized and their photophysical properties investigated. The complexes show interesting emission properties that, in the solid state, are dominated by the formation of aggregates due to the square‐planar geometry of the PtII species. Importantly, the formation of closed‐shell metal···metal interactions in such aggregates leads to new excited states that conveniently allow excitation in the visible region. The combination of the biologically active azetidinone agent and the intense and long‐lived emission are of particular interest for developing efficient multifunctional biomedical systems.
Composed analytical models for seismic assessment of reinforced concrete bridge columns
Authors: Liu Kuang‐Yen , Witarto Witarto , Chang Kuo‐Chun 
Published: October 2014

SummaryThis paper presents general composed analytical models to predict the behavior of reinforced concrete (RC) bridge columns. The analytical models were developed in OpenSees to represent the common hysteretic behavior of RC bridge columns. The proposed composed models can accommodate flexure failure, flexure‐shear failure, and pure shear failure, which are observed in existing RC bridge piers. The accuracy of the models was verified using data from the static cyclic‐loading experiments of 16 single columns and one multi‐column bent and dynamical experiment from two pseudo‐dynamic tests. The results showed that the analytical models could simulate the nonlinear behavior until the post‐failure behavior, including the strength degradation, the buckling of the reinforcement, and the pinching effect. Therefore, a global view of the behavior of reinforcement concrete is prescribed as simply as possible from the academic perspective, and these models are expected to provide sufficient accuracy when applied in engineering practice. Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis and Enhanced Electrochemical Performance of Sm‐Doped Sr2Fe1.5Mo0.5O6
Authors: Wang Y. , Li P. , Li H. , Zhao Y. , Li Y. 
Published: October 2014

AbstractSr2Fe1.5Mo0.5O6 (SFM) is a mixed ionic and electronic conductor which can be used as both anode and cathode materials in intermediate‐temperature solid oxide fuel cell. By doping Sm into the Sr‐site, the electrical conductivity of SFM is enhanced effectively. The single cell with a configuration of Sr1.8Sm0.2Fe1.5Mo0.5O6|La0.8Sr0.2Ga0.83Mg0.17O2.815| Ba0.5Sr0.5Co0.8Fe0.2O3 obtained maximum power densities of 459, 594, and 742 mW cm−2 with H2 as the fuel at 750, 800, and 850 °C, respectively. The results suggest that doping with Sm is a very promising way in enhancing the electrical conductivity of SFM and consequently can greatly improve its anode performance.
Composite Cathode Based on Redox‐Reversible NbTi0.5Ni0.5O4 Decorated with In Situ Grown Ni Particles for Direct Carbon Dioxide Electrolysis
Authors: Xie K. , Zhang J. , Xu S. , Ding B. , Wu G. , Xie T. , Wu Y. 
Published: October 2014

AbstractIn this work, ceramic NbTi0.5Ni0.5O4 is reversibly transformed to nickel‐anchored electronic‐conducting Nb1.33Ti0.67O4 composite for the use of direct carbon dioxide electrolysis at intermediate temperatures. The reduced composites Nb1.33Ti0.67O4 + Ni demonstrate excellent electrical properties, which have been accordingly correlated to electrochemical performance of the composite cathode. The direct electrolysis of 100% CO2 is then performed and the maximum Faraday current efficiency reaches as high as 65%. It is found that adding 3% H2O to CO2 remarkably improves the electrolysis performances and the current efficiency is accordingly enhanced by approximately 20%. The reversible transformation between NbTi0.5Ni0.5O4 and Nb1.33Ti0.67O4 + Ni sample significantly contributes to the promising thermal and redox cycling performance while the anchored interface between Ni and Nb1.33Ti0.67O4 improves cathode stability.
A Comparison between the Nephrotoxic Profile of Gentamicin and Gentamicin Nanoparticles in Mice
Authors: Jamshidzadeh Akram , Heidari Reza , Mohammadi‐Samani Soliman , Azarpira Negar , Najbi Asma , Jahani Parisa , Abdoli Narges 
Published: October 2014

ABSTRACTAminoglycoside antibiotics are widely used against Gram‐negative infections. On the other hand, nephrotoxicity is a deleterious side effect associated with aminoglycoside therapy. Gentamicin is the most nephrotoxic aminoglycoside. Because of serious health complications ensue the nephrotoxicity induced by aminoglycosides, finding new therapeutic strategies against this problem has a great clinical value. This study has attempted to compare the nephrotoxic properties of gentamicin and a new nanosized formulation of this drug in a mice model. Animals were treated with gentamicin (100 mg/kg, i.p. for eight consecutive days) and nanogentamicin (100 mg/kg, i.p. for eight consecutive days). Blood urea nitrogen (BUN), plasma creatinine levels, and histopathological changes of kidney proximal tubule were monitored. It was found that gentamicin caused severe degeneration of kidney proximal tubule cells and an increase in serum creatinine and BUN. No severe injury was observed after nanogentamicin administration. This study proved that nanosized gentamicin is less nephrotoxic.