bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequential multimodality bronchoscopic investigation of peripheral pulmonary lesions
Authors: Steinfort Daniel P. , Bonney Asha , See Katharine , Irving Louis B. 
Published: November 2015

Multiple guidance modalities may be combined during bronchoscopic investigation of peripheral pulmonary lesions (PPLs). The relative contribution of each modality to diagnostic performance remains uncertain.Endobronchial ultrasound (EBUS) with virtual bronchoscopy (VB) was routinely performed, with electromagnetic navigation (EMN) utilised only where EBUS was unable to locate PPLs or where the probe was adjacent to the lesion and on-site cytologic examination was nondiagnostic.236 consecutive patients with 245 PPLs had lesion size 22.8±12.4 mm (mean±sd). PPLs were localised using EBUS+VB alone in 188 (77%) and was diagnostic in 134 of these (71.3%). EBUS localisation was predicted by PPL size (23.7±10.5versus19.7±9.8 mm, p=0.003), but not by bronchus sign, PPL–hilum distance or PPL–pleura distance. EMN in 57 patients achieved EBUS localisation in a further 17 patients (30.9%), improving overall visualisation yield to 85%. Nine of these 57 procedures achieved a definitive diagnosis (16%), improving overall diagnostic yield to 58.4%. Probe position and lesion type influenced overall diagnostic yield. Sensitivity for diagnosis of lung cancer was 70% (131/188; 95% CI 63–76%).Localisation rate and diagnostic sensitivity of radial probe EBUS+VB alone for diagnosis of PPLs is high. EBUS localisation rates and procedural yield are improved only modestly (by 8% and 4%, respectively) with addition of EMN. Sampling following EMN should include all available methods to maximise diagnostic yield.
Sex-specific features of emphysema among current and former smokers with COPD
Authors: Hardin Megan , Foreman Marilyn , Dransfield Mark T. , Hansel Nadia , Han MeiLan K. , Cho Michael H. , Bhatt Surya P. , Ramsdell Joe , Lynch David , Curtis Jeffrey L. , Silverman Edwin K. , Washko George , DeMeo Dawn 
Published: November 2015

Recent studies suggest that males with chronic obstructive pulmonary disease (COPD) have more emphysema than females. It is not known if these differences persist across degrees of COPD severity. Our aim was to identify sex-specific differences in quantitative emphysema within COPD subgroups based on COPD severity.We included non-Hispanic white and African-American subjects from the COPDGene study with at least 10 pack-years of smoking and COPD Global Initiative for Chronic Obstructive Lung Disease (GOLD) spirometry grade II or greater. We examined sex-specific differences in log-transformed emphysema (log per cent low-attenuation area (%LAA)) by GOLD spirometry grade among subjects with early-onset COPD (<55 years old) and advanced emphysema (>25% emphysema).Compared with females, males had higher log %LAA: overall (1.97±1.4versus1.69±1.6, β=0.32 (0.04), p=1.34×10−14), and among non-Hispanic white (p=8.37×10−14) and African-American subjects (p=0.002). Females with early-onset COPD, severe emphysema and GOLD grade IV COPD had similar emphysema as males, but markedly fewer pack-years smoking (early-onset, p=0.01; severe emphysema and GOLD grade IV, p<0.001).This study identifies subsets of female smokers with COPD who are particularly susceptible to parenchymal destruction.
Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study
Authors: Quint Jennifer K. , Millett Elizabeth R.C. , Joshi Miland , Navaratnam Vidya , Thomas Sara L. , Hurst John R. , Smeeth Liam , Brown Jeremy S. 
Published: November 2015

There is a paucity of data on incidence, prevalence and mortality associated with non-cystic fibrosis bronchiectasis.Using the Clinical Practice Research Datalink for participants registered between January 1, 2004 and December 31, 2013, we determined incidence, prevalence and mortality associated with bronchiectasis in the UK and investigated changes over time.The incidence and point prevalence of bronchiectasis increased yearly during the study period. Across all age groups, the incidence in women increased from 21.2 per 100 000 person-years in 2004 to 35.2 per 100 000 person-years in 2013 and in men from 18.2 per 100 000 person-years in 2004 to 26.9 per 100 000 person-years in 2013. The point prevalence in women increased from 350.5 per 100 000 in 2004 to 566.1 per 100 000 in 2013 and in men from 301.2 per 100 000 in 2004 to 485.5 per 100 000 in 2013. Comparing morality rates in women and men with bronchiectasis in England and Wales (n=11 862) with mortality rates in the general population from Office of National Statistics data showed that in women the age-adjusted mortality rate for the bronchiectasis population was 1437.7 per 100 000 and for the general population 635.9 per 100 000 (comparative mortality figure of 2.26). In men, the age-adjusted mortality rate for the bronchiectasis population was 1914.6 per 100 000 and for the general population 895.2 per 100 000 (comparative mortality figure of 2.14).Bronchiectasis is surprisingly common and is increasing in incidence and prevalence in the UK, particularly in older age groups. Bronchiectasis is associated with a markedly increased mortality.
RETRACTED ARTICLE: MiR-362-5p promotes the malignancy of chronic myelocytic leukaemia via down-regulation of GADD45α
Authors: Yang Peng , Ni Fang , Deng Rui-qing , Qiang Guo , Zhao Hua , Yang Ming-zhen , Wang Xin-yi , Xu You-zhi , Chen Li , Chen Dan-lei , Chen Zhi-jun , Kan Li-xin , Wang Si-Ying 
Published: November 2015

Abstract
Background
MicroRNAs (miR, miRNAs) play pivotal roles in numerous physiological and pathophysiological contexts. We investigated whether miR-362-5p act as an oncogene in chronic myeloid leukaemia (CML) and aimed to understand its potential underlying mechanisms.

Methods
We compared the miR-362-5p expression levels between CML and non-CML cell lines, and between fresh blood samples from CML patients and normal healthy controls using quantitative real-time PCR (qPCR). Cell counting kit-8 (CCK-8) and Annexin V-FITC/PI analyses were used to measure the effects of miR-362-5p on proliferation and apoptosis, and Transwell assays were used to evaluate migration and invasion. A xenograft model was used to examine in vivo tumourigenicity. The potential target of miR-362-5p was confirmed by a luciferase reporter assay, qPCR and western blotting. Involvement of the JNK1/2 and P38 pathways was investigated by western blotting.

Results
miR-362-5p was up-regulated in CML cell lines and fresh blood samples from CML patients, and was associated with Growth arrest and DNA damage-inducible (GADD)45α down-regulation. Inhibition of miR-362-5p simultaneously repressed tumour growth and up-regulated GADD45α expression in a xenograft model. Consistently, the knockdown of GADD45α expression partially neutralized the effects of miR-362-5p inhibition. Furthermore study suggested that GADD45α mediated downstream the effects of miR-362-5p, which might indirectly regulates the activation of the JNK1/2 and P38 signalling pathways.

Conclusion
miR-362-5p acts as an oncomiR that down-regulates GADD45α, which consequently activates the JNK1/2 and P38 signalling. This finding provides novel insights into CML leukaemogenesis and may help identify new diagnostic and therapeutic targets.
Functional remediation in bipolar disorder: 1-year follow-up of
neurocognitive and functional outcome
Authors: Bonnin C. M. , Torrent C. , Arango C. , Amann B. L. , Solé B. , González-Pinto A. , Crespo J. M. , Tabarés-Seisdedos R. , Reinares M. , Ayuso-Mateos J. L. , García-Portilla M. P. , Ibañez Á. , Salamero M. , Vieta E. , Martinez-Aran A. ,   CIBERSAM Functional Remediation Group
Published: November 2015

BackgroundFew randomised clinical trials have examined the efficacy of an
intervention aimed at improving psychosocial functioning in bipolar
disorder.AimsTo examine changes in psychosocial functioning in a group that has been
enrolled in a functional remediation programme 1 year after baseline.MethodThis was a multicentre, randomised, rater-masked clinical trial comparing
three patient groups: functional remediation, psychoeducation and
treatment as usual over 1-year follow-up. The primary outcome was change
in psychosocial functioning measured by means of the Functioning
Assessment Short Test (FAST). Group×time effects for overall psychosocial
functioning were examined using repeated-measures ANOVA (trial
registration NCT01370668).ResultsThere was a significant group×time interaction for overall psychosocial
functioning, favouring patients in the functional remediation group
(F = 3.071, d.f. = 2, P =
0.049).ConclusionsImprovement in psychosocial functioning is maintained after 1-year
follow-up in patients with bipolar disorder receiving functional
remediation.
Ras-activated Dsor1 promotes Wnt signaling in Drosophila development
Authors: Hall Eric T. , Verheyen Esther M. 
Published: November 2015

ABSTRACT
Wnt/Wingless (Wg) and Ras–MAPK signaling both play fundamental roles in growth and cell fate determination, and when dysregulated, can lead to tumorigenesis. Several conflicting modes of interaction between Ras–MAPK and Wnt signaling have been identified in specific cellular contexts, causing synergistic or antagonistic effects on target genes. We find novel evidence that the Drosophila homolog of the dual specificity kinases MEK1/2 (also known as MAP2K1/2), Downstream of Raf1 (Dsor1), is required for Wnt signaling. Knockdown of Dsor1 results in loss of Wg target gene expression, as well as reductions in stabilized Armadillo (Arm; Drosophila β-catenin). We identify a close physical interaction between Dsor1 and Arm, and find that catalytically inactive Dsor1 causes a reduction in active Arm. These results suggest that Dsor1 normally counteracts the Axin-mediated destruction of Arm. We find that Ras–Dsor1 activity is independent of upstream activation by EGFR, and instead it appears to be activated by the insulin-like growth factor receptor to promote Wg signaling. Taken together, our results suggest that there is a new crosstalk pathway between insulin and Wg signaling that is mediated by Dsor1.
Formation of analytical data for multivariate analysis using algebraic model of constructive logic
Authors: Fedorov S. , Kitanina K. , Khromushin V. , Khromushin O. 
Published: November 2015

Mathematical device of algebraic model of constructive logic has been used for many years for multivariate analysis in medicine and biology. The resulting mathematical model is represented by a set of output components in the form of factors indicating the detection restrictions, which are united by the sign of con-junction (indicating joint influence). Each resulting component is characterized by a capacity, which is the es-sence of the number of rows in the table with the same factors and their intervals of definition. These capacities characterize the degree of influence of the resulting component on the overall result. The input table must not contain contradictions (when the goal is achieved and not achieved when the same values of the factors). For this purpose, the computer program provides for an exception to those target lines, which coincide with non-target rows. However, this is not always acceptable in cases of a large number of matching target lines and unit numbers of non-target rows or vice versa, because a large number of cases is excluded because of a single non-target rows or single target lines. These contradictions arise, primarily, due to the probabilistic nature of the cases. This is clearly seen in the monitoring of mortality.
In this article the authors propose three ways optimum yield conflicting source data, based on the excess multiplicity of frequencies matching target and non-target cases and estimates of confidence intervals. The pro-posed methods are examined by analyzing data on deaths of persons aged 18 years and older, residents of the Tula region for 2007-2014 (total 208269 cases). An age cohort 45-54 years is a goal of study.
The application of methods of optimum yield conflicting source data is a necessity, which not only im-proves the mathematical model, but, in some cases, is the only way to perform multivariate analysis. All pro-posed methods have their own scope of use, depending on the circumstances.
Efficiency of pseudomonas aeruginosa and Escherichia coli to treatment of effluent petroleum wastewater from AI-Nasiriya refinery – Iraq
Authors: AI-Jawhari Ihsan Flayyih Hasan , Mhail Noor Jabar , AI-RuthaAli Saher Abed 
Published: November 2015

<p style="direction: ltr;" dir="RTL">Four bacteria isolated from the soil contaminated with petroleum hydrocarbon and wastewaters from the refinery located in the south part of AI-Nasiriya city in Iraq,by using dilution method.The results showed that <em>Pseudomonas aeruginosa</em> was more dominant with 100% in soil and wastewaters in inside of refinery,and 93%,95% in soil and wastewaters in outside the refinery respectively.The results showed that the second dominant of bacteria was <em>Esherchia coil</em> with 92%,98% in soil and wastewaters in inside the refinery,and 83%,88% in soil and wastewaters in outside of refinery.The remaining two species of bacteria isolated with a very low frequency,these bacteria were <em>Bacillus subtilis</em> and <em>Klebsiella sp</em>., <em>B.subtilis</em> was obtained with 10%,8% in soil and wastewaters in inside the refinery,and 10%,3% in soil and wastewaters in outside of refinery .In the same time that <em>Klebsiella sp</em>. Was obtained with 10% in soil and wastewaters in inside the refinery,and 8%,3% in soil and wastewaters in outside the refinery.The results showed that mixed two bacteria (high frequency)were more efficient to decrease Biological Oxygen Demande(BOD)with 59% in pH 4,0.5gm / I salt (NaCI) concentration.Chemical Oxygen Demande (COD) was decreased to 75%.The results showed that the Total Acidity(TA) in wastewater were increased to 82% mg / I in 40c<sup>o</sup> ,pH 8 and 2.0 gm/ I NaCI , and Total Suspended Solid (TSS) was decreased to 50 mg / I in 40c<sup>o</sup>, pH,2.0 gm / I NaCI . The results showed that the Total Petroleum Hydrocarbon (TPH) was removal with 99.99%, and in the same time the numbers of mixed bacteria were increased to 5x10<sup>8</sup> after incubation 48h in 40c<sup>o</sup> .</p>
Preservative Characteristics of Ascorbic Acid on Color, Texture and Fatty Acid of Cold-Smoked Fish
Authors: Kilic Aydin , Oztan Aydin 
Published: November 2015

Abstract
The objective of this study is to investigate the preservative characteristics of ascorbic acid (A) on the color, texture and fatty acids (FA) of cold-smoked fish. The fish (~250 g) were treated with six different formulation of brine prepared with 10% salt, which is the control(C), treated with 0.4% NaNO2 (N4), 0.2% NaNO2(N2) and only 2.5% A and their combinations (N4A, N2A). The sample groups were cold smoked, then stored at ±4°C and analyzed for 15 days intervals. The results showed that ascorbic acid did not have any negative effect on color, texture or sensory characteristics while there were significant preservative effects on FA. The most stable groups were N and A combinations. The PUFA (Polyunsaturated FA), PUFAω-3, PUFAω-6 and UFA (Unsaturated FA) of N4A and N2A were higher than group C and A. Accordingly, it is expected that, in terms of PUFAω-3 and PUFAω-6, the combination of N and A can contribute to the lipid stability.
Simulation in System-Level Based on Model Order Reduction for a Square-Wave Micromixer
Authors: Chen Xueye , Shen Jienan 
Published: November 2015

Abstract
With the aim to optimize design, a simulation in system level has been presented for the square-wave micromixer in this article. The square-wave micromixer is divided into straight channels and square-wave units. The reduced-order model based on proper orthogonal decomposition is applied in calculating concentration of the sample in the straight channels, and numerical simulation is applied in calculating concentration of the sample in the square-wave units. The data can mutually be transferred between straight channels and square-wave units by data fitting and interpolation. The maximal relative deviation is 1.52% between simulation in system-level and only simulation. The computational efficiency will be improved significantly with the numbers of straight channels increasing. The Polymethyl methacrylate (PMMA) micromixer is fabricated with mill and hot bonding method. The mixing experiment of fluorescein sodium solution with different concentrations is carried out to verify simulation. The relative deviations between simulation in and experimental results are below 8.26%.
“A Miner Knows Better Than Anybody You Have Little Power Over Mother Nature”: Exploring Genesis 1:26–31 and the Concepts of Control and Power with South Derbyshire Coal Miners
Authors: Webster Tiffany 
Published: November 2015

AbstractThis article seeks to analyze a contextually-reflexive reading of Genesis 1:26–31 that was produced by a group of contemporary “ordinary” readers – in this case, a group of South Derbyshire coal miners. The coal miners used Genesis 1:26–31 as a literary platform upon which they interrogated two principal issues: How ‘masculinity’ is constructed, performed, understood, enforced, and legitimized in coal mining culture; and, what the relationship is between humanity and Earth. This resulted in a reading whereby an attempt was made to synthesize how a man’s understanding of ‘masculinity’ impacts upon his relationship with, and attitude towards, Earth.
“Behold the Man”? Subverting Imperial Masculinity in the Gospel of John
Authors: Ripley Jason J. 
Published: November 2015

AbstractModern variations of the “Muscular Christianity” movement emphasize Jesus’ masculinity in various dimensions, inspired in part by the idealized masculinity of Jesus portrayed in the Gospel of John. However, these constructions overlook the Roman context of the Fourth Gospel, and thus miss its critical and subversive engagement with imperial masculinity. I argue that the Gospel of John forges its portrait of Jesus in the rhetorical crucible of honor andvirtus, where Roman masculinity was socially constructed and contested. Within the divergent configurations of manliness that emerge in the early imperial period, the glorious death of John’s Jesus appeals to and subverts reigning constructions of imperial masculinity. Through the portrayal of Jesus’ unflappable courage and conquering via his death, the rhetoric of the Fourth Gospel lays claim to the ideal of Romanvirtus, especially as set forth in the rhetorized renditions of anti-imperial Stoic martyrs (such as Cato and Seneca). However, by constructing Jesus’ masculinity around his bound, beaten, crucified and penetrated body, the Fourth Gospel critiques and subverts imperial configurations of hegemonic manliness and domination. John’s glorification of the cross provides a paradigm of masculinity that exalts courageous critique and rejection of imperial violence even at the cost of one’s life, thereby inverting the shame of crucifixion and imbuing it with honor andvirtus. In so doing, imperial notions of martial masculinity and power are subverted and reconfigured around the cross, thereby opening up new possibilities for the performance of masculinity by ancients and moderns alike.
The Reception of the Bible in the Construction of Masculinities in Jewish and Christian Con/Texts
Authors: Smit Peter-Ben , Creangă Ovidiu , van Klinken Adriaan 
Published: November 2015

AbstractThe introduction to this special issue reviews the articles collected and presented in the volume. After an overview of the contents, the chapter turns to a more refined discussion of the insights resulting from the collection. These insights concern the productivity as well as limitations of canonicity, the importance of contextuality, the embodied practice of masculinity and the subsequent need to acknowledge intersectionality, and finally, it problematizes the rhetoric of ‘tradition(al)’ or ‘biblical’ masculinity. Mapping the future of the study of biblical reception and masculinities, the introduction identifies key issues and areas for further research. These are the necessity of a greater emphasis on multidisciplinarity, the need to demonstrating hermeneutical self-awareness, and a broadening of the scope of the field to include the Qur’an and Muslim cultures as well as newly emerging forms of Christianity in the global South. These features are key to the study of the reception of biblical masculinities going forward.
Use of laboratory information system data for indirect estimation of reference interval for vitamin B12
Authors: Oncel Mufide , Sahin Emel , Kiyici Aysel , Adam Bahattin 
Published: November 2015

Abstract

Background: In common, clinical laboratories use reference intervals recommended by the manufacturers. Various factors affect laboratory tests such as age, sex, diet and genetics. So, it is recommended for each laboratory to determine its own reference ranges for each test used. We aimed to establish our reference interval for vitamin B12.

Methods: The data archive of laboratory information system was searched for a 1-year period between January and December, 2013. Among 2526 subjects searched for vitamin B12, 2368 remained (1–70 years old, 512 male and 1856 female) when we excluded the outliers for estimation of reference range for vitamin B12 with nonparametric method according to National Committee for Clinical Laboratory Standards (NCCLS) C28-A3 guidelines. Serum levels of vitamin B12 were determined with electrochemiluminescent technique.

Results: New reference interval for vitamin B12 derived from our results was 101–702 pg/mL, and was not affected by gender.

Conclusions: New reference interval was different from the one recommended by the manufacturer. We suggest that established reference interval reflects our population better than the values recommended by the manufacturer.
Optical integrated chips with micro and nanostructures for refractive index and SERS-based optical label-free sensing
Authors: Liu Liu , Jin Mingliang , Shi Yaocheng , Lin Jiao , Zhang Yuan , Jiang Li , Zhou Guofu , He Sailing 
Published: November 2015

Abstract:
Label-free optical biosensing technologies have superior abilities of
quantitative analysis, unmodified targets, and ultrasmall sample volume,
compared to conventional fluorescence-label-based sensing techniques, in
detecting various biomolecules. In this review article, we introduce our recent
results in the field of evanescent-wavebased refractive index sensing and
surface enhanced Raman scattering (SERS)-based sensing, both of which are
promising platforms for label-free optical biosensors. First,
silicon-on-insulator (SOI) nanowire waveguide and metallic surface plasmon
resonance (SPR)-based refractive index sensing are discussed. In order to
improve the detection limit, phase interrogation techniques are introduced to
these types of sensors based on prism-coupled SPR and SOI microring resonators.
A detection limit in the order of 10−6 refractive index unit is achieved.
Detection of 16.7 pM anti-IgG is also demonstrated based on the SPR devices.
Second, SERS substrates based on various nanometallic structures are discussed.
Metallic nanowire arrays and inverted nanopyramids and grooves with a thin metal
surface are fabricated based on anisotropic wetetching of silicon substrates.
Both structures have demonstrated a Raman signal enhancement on the order of
107. In order to improve the extraction efficiency of the Raman signal at a high
wave number, a nano-bowtie array substrate is fabricated, which exhibits double
resonances at both the excitation wavelength and the desired Raman scattering
wavelength. Experimental results have shown that this double-resonance structure
can further enhance the received Raman signal, as compared to conventional SERS
substrates with only one resonance at the excitation wavelength.