bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anterior cruciate ligament reconstruction: Effect of graft tunnel position on early to mid-term clinical outcomes
Authors: Mann Oliver , Al-Dadah Oday 
Published: August 2024

BACKGROUND
Patient reported outcome measures (PROMs) can be used to assess knee function following anterior cruciate ligament (ACL) reconstruction. Intra-operatively, femoral and tibial tunnels are created to accommodate the new ACL graft. It is postulated that there is an optimum position and orientation of these tunnels and that outcomes from this procedure are affected by their position.
AIM
To evaluate the influence of graft tunnel position on early to mid-term clinical outcomes following ACL reconstruction.
METHODS
Six PROMs were collected following ACL reconstruction which included the Knee Injury and Osteoarthritis Outcome Score (KOOS), International Knee Documentation Committee, Lysholm, Tegner, EuroQol-5 Dimension-5 level, and Short Form 12-item Health Survey. A total of 8 radiological parameters were measured from post-operative X-rays relating to graft tunnel positions. This data was analysed to assess for any correlations between graft tunnel position and post-operative PROMs.
RESULTS
A total of 87 patients were included in the study with a mean post-operative follow-up of 2.3 years (range 1 to 7 years). Posterior position of tibial tunnel was associated with improved KOOS quality of life (rho = 0.43, P = 0.002) and EQ-5D VAS (rho = 0.36, P = 0.010). Anterior position of EndoButton femoral tunnel was associated with an improved EQ-5D index (rho = -0.38, P = 0.028). There were no other significant correlations between any of the other radiological parameters and PROM scores.
CONCLUSION
Overall, graft tunnel position had very little correlation with clinical outcomes following ACL reconstruction. A few (posterior) tibial tunnel and (anterior) EndoButton femoral tunnel measurements were associated with better PROMs.
Blood metal concentrations and cardiac structure and function in total joint arthroplasty patients
Authors: Brennan Peter C , Peterson Stephanie M , O'Byrne Thomas J , Laporta Mariana L , Wyles Cody C , Jannetto Paul J , Kane Garvan C , Vassilaki Maria , Maradit Kremers Hilal 
Published: August 2024

BACKGROUND
There is concern regarding potential long-term cardiotoxicity with systemic distribution of metals in total joint arthroplasty (TJA) patients.
AIM
To determine the association of commonly used implant metals with echocardiographic measures in TJA patients.
METHODS
The study comprised 110 TJA patients who had a recent history of high chromium, cobalt or titanium concentrations. Patients underwent two-dimensional, three-dimensional, Doppler and speckle-strain transthoracic echocardiography and a blood draw to measure metal concentrations. Age and sex-adjusted linear and logistic regression models were used to examine the association of metal concentrations (exposure) with echocardiographic measures (outcome).
RESULTS
Higher cobalt concentrations were associated with increased left ventricular end-diastolic volume (estimate 5.09; 95%CI: 0.02-10.17) as well as left atrial and right ventricular dilation, particularly in men but no changes in cardiac function. Higher titanium concentrations were associated with a reduction in left ventricle global longitudinal strain (estimate 0.38; 95%CI: 0.70 to 0.06) and cardiac index (estimate 0.08; 95%CI, -0.15 to -0.01).
CONCLUSION
Elevated cobalt and titanium concentrations may be associated with structural and functional cardiac changes in some patients. Longitudinal studies are warranted to better understand the systemic effects of metals in TJA patients.
Needle arthroscopic-assisted repair of tibio-fibular syndesmosis acute injury: A case report
Authors: Wojtowicz Blazej G , Domzalski Marcin , Lesman Jedrzej 
Published: August 2024

BACKGROUND
Acute injuries to the tibiofibular syndesmosis, often associated with high ankle sprains or malleolar fractures, require precise diagnosis and treatment to prevent long-term complications. This case report explores the use of needle arthroscopy as a minimally invasive technique for the repair of tibiofibular syndesmosis injuries.
CASE SUMMARY
We report on a 40-year-old male patient who presented with a trimalleolar fracture and ankle subluxation following a high ankle sprain. Due to significant swelling and poor soft tissue quality, initial management involved external stabilization. Subsequently, needle arthroscopy was employed to assess and treat the tibiofibular syndesmosis injury. The procedure, performed under spinal anesthesia and fluoroscopic control, included nanoscopic evaluation of the ankle joint and reduction of the syndesmosis using a suture button. Follow-up assessments showed significant improvement in pain levels, range of motion, and functional scores. At 26 weeks post-procedure, the patient achieved full range of motion and pain-free status. Needle arthroscopy offers a promising alternative for the management of acute tibiofibular syndesmosis injuries, combining diagnostic and therapeutic capabilities with minimal invasiveness.
CONCLUSION
This technique may enhance clinical outcomes and reduce recovery times, warranting further investigation and integration into clinical practice.
The Association Between Adherence And Blood Pressure Status Of Cardiovascular Disease Patients At Hospital W
Authors: Alvino Muchammad Sheva , Zulfa Ilil Maidatuz , Ulfa Ninik Mas 
Published: August 2024

Cardiovascular diseases (CVD) are the leading causes of global mortality. Patient adherence to medication and healthy lifestyle plays a crucial role in blood pressure control and overall CVD management. Therefore, assessing the association between patient adherence levels and blood pressure status is essential in the prevention and treatment of these diseases. This study was purposed to evaluate the association between patient adherence levels and the status of blood pressure at W Hospital, Surabaya. This was an observational study collecting data prospectively from 73 respondents during January to March 2024. Descriptive analysis was conducted using frequency distribution tables while the association between adherence and blood pressure status was analyzed using morisky green levine The findings revealed that the majority of patients had moderate adherence levels (54.79%) and most of patients had controlled blood pressure (61.64%). However, a portion of patients showed low adherence (6.85%) and uncontrolled blood pressure (38.36%). Analysis using fisher exact test indicated a significant relationship between patient adherence levels and blood pressure status (p = 0.012). These findings underscore the importance of evaluating and managing patient adherence in the management of cardiovascular diseases. Targeted intervention measures, including patient education and appropriate therapeutic planning, can help improve blood pressure control and patient clinical outcomes.
Enhancing interprofessional collaboration in medication management
Authors: Almanna Mohammad Abdullah , Alanazi Dhiyaa Manawer , Enazi Sami Mohammed Al , Alaboush Khalid Salem , Alaujan Badour Subhi , Zamzami Bander Ahmad , Alanazi Nadin Lafi , Ababtain Hind Amer , Altalouhi Fatmah Malfi , Alenizi Eman Smair , Aldossary Ghuzyel Fahad , Alowaidan Salwa Rashed , Al-Rashudi Khaled Abdul Rahman Suleiman , Alharbi Shayem Hamdan , Alnuwmasiu Fahad Madallah , Alonazi Fares Motalq , Alwahdani Mohammed Nuhayr , Alshammary Nasser Sihli 
Published: August 2024

Background _ Although there is ample data supporting the positive impact of nurse-pharmacist cooperation on clinical health outcomes and cost-effectiveness in increasing drug safety among adults in acute care settings, there is a lack of research in community settings. Aim of Work – The objective is to consolidate information and examine the nurse's role in medication management during transitional care. Methods – A comprehensive systematic review was done. A systematic search was conducted in electronic databases comprising PubMed (including Medline), Web of Knowledge, Scopus, and Cinahl, covering the period from January 2010 to April 2021. covered in this study were original qualitative and quantitative research papers published in English that specifically examined the nurse's involvement in managing medications during transitional care. This covered situations when patients moved between short-term, long-term, and community healthcare settings. Results – Through the search method, 10 papers were retrieved. These studies were published in English between the years 2014 and 2021. Their primary emphasis was on the nurse's involvement in managing patients' medications throughout transitional care in different healthcare settings. The review results were presented narratively using three categories devised by the authors, due to differences in the objectives and approaches of the chosen research.
Pengaruh Penggunaan Aplikasi Canva terhadap Minat Belajar Siswa pada Materi Matriks Kelas XI SMAN 1 Cigugur
Authors: Pebriyanto Riyan , Hermawan Hermawan 
Published: August 2024

Canva learning media is an online platform for graphic design in designing various creative designs to make it easier for users, such as designing posters, info graphics, and presentations. Not only for designing, but can also be used as a learning medium for teachers, students and schools in classroom learning. The aim of this research is to determine the effect of using the Canva application on interest in learning in class XI matrix material at SMAN 1 Cigugur. This research uses a quantitative approach with a quasi-experimental method. The research design is nonequivalent control group design. The research sample consisted of 67 students in two classes, one control class, namely class XI 5 and one experimental class, namely class the results of data analysis show that there is an influence of applying Canva learning media on interest in learning. Meanwhile, in the Independent Sample T Test, a significance result was obtained of 0.000 < 0.05, so it can be concluded that there is a significant difference between the average results of learning interest in students who use Canva learning media and conventional learning using the PDF file application
Adverse Effects of Propranolol on Testis and Heart Tissue of Albino Mice
Authors: Shaheen Javaria , Asmatullah . , Azam Azeem , Fahid Ata Ul Mustafa , Faseeh Hamza , Anjum Farhan , Faisal Muhammad Rehan , Latif Maryam 
Published: August 2024

Propranolol is a non-selective, beta-adrenergic antagonist drug useful in various clinical disorders such as schizophrenia, anxiety, agitation, Autism Spectrum Disorder (ASD), hypertension, insomnia and other psychosis. Objective: To investigate the probable toxic effects of propranolol on the testis and heart of male mice. Methods: Twenty mature male mice were randomized and divided into four groups. The control group received distilled water, and the three experimental dose groups, D-I, D-II, and D-III, received 0.1 ml of propranolol using an insulin syringe with a butterfly needle in three different concentrations i.e. 0.15 µg/g, 0.30 µg/g, and 0.60 µg/g of their body weight, respectively, for a period of four weeks. After completion of the experiment, these mice were weighed, anaesthetized, and dissected. Their serum was collected by the intracardial puncture technique for the analysis of testosterone. Testes and heart were separated from the control and experimental groups for morphometric and histopathological studies. Results: The mice exposed to propranolol revealed a significant reduction in testosterone (P≤ 0.01) and body weight (P≤ 0.01). Histopathological findings also revealed laminar/tubular degeneration, vaccination, and an enlarged amyloid body in testicle tissues, while damaged striated strips and irregular arrangements of nuclei were observed in heart tissues. Conclusions: This investigation clearly reveals the adverse effects of propranolol on the testis and heart tissue of albino mice.
THE EFFECTIVENESS OF GUARANTEES AND INCENTIVE REGULATIONS TO ENCOURAGE INVESTMENT IN ALGERIAN LEGISLATION
Authors: Rabia Zahia 
Published: August 2024

Objectives: The Algerian state is betting on attracting foreign investments for their effective contribution to achieving economic development and resilience. The importance of this topic is highlighted by showcasing the efforts made by the state to encourage national and foreign investment by adapting its legislative frameworks in this area to make it work towards providing a more attractive investment environment to attract these investors.

Methods: To this end, laws regulating investment have been issued, which have undergone amendments, revisions, and cancellations during the economic reform phase. These legal changes establish legal guarantees and incentive systems to create a suitable business environment for Algeria's investment climate.

Results: We aim to address the most significant developments brought about by Investment Law No. 22-18, whether related to the guarantees or the incentive systems granted to both national and foreign investors.

Conclusion: In conclusion, we reached several findings, the most important of which is the Algerian legislator's adoption of a set of newly established guarantees and incentives for investment projects, and the organization of several advantages that the investment project benefits from within the incentive systems.
AI-based big data analysis of user-generated content to understand adherence in oral hormone receptor-positive advanced breast cancer treatment: A literature review and patient-centered approach using natural language processing
Authors: Scholz Stefanie , Winkler Christian , Niescken Svenja 
Published: August 2024

Background: Understanding patients' adherence needs is crucial for the success of therapies, particularly for chronic illnesses and cancer. The shift from intravenous to oral anticancer medication enhances patient independence but may threaten adherence. This study aims to identify patients' concerns and needs for treatment of oral hormone receptor-positive for advanced breast cancer (CDK4/6 inhibitors).
Methodology: A comprehensive literature review on factors influencing patient adherence was conducted, followed by AI-based big data analyses of user-generated content. Techniques such as natural language processing and machine learning-based word embeddings were applied to achieve a patient-centered understanding of adherence.
Results: The literature review shows that adherence is often overlooked in clinical research due to the impracticality of long-term monitoring in most trial designs. This highlights the need for alternative methods such as real-world data and AI-based analyses to understand patients' long-term adherence to treatment. Key factors influencing adherence to oral breast cancer treatment include the cost-benefit ratio in terms of survival and quality of life, realistic expectations regarding side effects, social support and personalized care. AI analysis of user-generated content supports these findings and reveals more frequent discussions on non-adherence in early breast cancer stages. Semantic graphs and topic modeling also identified additional patient concerns and informational needs for better patient communication.
Conclusions: Enhancing patient-centeredness is crucial for improving adherence and persistence to oral treatment for breast cancer. The increased autonomy provided by oral medications offers a significant opportunity for healthcare providers to empower patients in managing their treatment. Comprehensive support, including addressing emotional and psychological issues, is essential, especially in advanced breast cancer stages.
Exploring Biotechnological Advancement in Coriander Cultivation: A review
Authors: Dr. Varsha Kumari  , Dr. Ashok Kumar Meena  , Dr. Deepak Gupta  , Dr. B. L. Kumhar  , Dr. Bhuri Singh  , Dr. Heena Saheewala  , Dr. G. K. Mittal  , Dr. Giradhari Lal Yadav  , Amarnath Dabaria  , Rupnarayan Sharma  
Published: August 2024

Coriander (Coriandrum sativum L.) is an essential herb used widely in culinary, medicinal, and aromatic applications globally. Key developments in coriander improvement including enhances yield, stress tolerance and phytochemical production. The potential of biotechnological approaches in addressing challenges such as disease resistance, environmental stresses and quality improvement is well understood. Genetic modification techniques such as CRISPR/Cas9 have enabled precise gene editing for traits like disease resistance, herbicide tolerance, and improved nutrient uptake. Moreover, biotechnological tools enable precise gene editing, allowing for targeted modifications without introducing foreign genes. This approach ensures the safety and regulatory compliance of genetically modified coriander varieties, addressing concerns related to consumer acceptance and environmental impact. Additionally, advancements in tissue culture protocols have facilitated rapid propagation of elite coriander varieties, circumventing issues related to seed germination and maintaining genetic purity. Molecular breeding strategies employing marker-assisted selection (MAS) and genomic selection have expedited the development of high-yielding coriander cultivars with desirable agronomic traits. “omics” approaches including genomics, transcriptomics, and metabolomics in elucidating the genetic basis of important traits in coriander provide valuable insights into the molecular mechanisms underlying coriander development, stress responses, and secondary metabolite biosynthesis. This review provides an overview of recent biotechnological advancements in coriander research focusing on areas such as genetic engineering, tissue culture, metabolomics, and molecular breeding aimed at enhancing coriander yield, quality, and stress resilience.
Response of coriander varieties to various levels of fertility under different cutting
Authors: Patel Shaileshbhai Mulchandbhai 
Published: August 2024

An investigation was carried with an objective to work out the optimum fertilizer dose under different cutting management system for different varieties at Seed Spices Research Station, Sardarkrushinagar Dantiwada Agricultural University, Jagudan, during rabi 2015-16 to 2017-18. The soil was loamy sand in texture, neutral in soil reaction, with low in organic carbon, medium in available phosphorus and potash. The treatments comprised of two varieties V1 : GDLC-1 and V2: GCo 2, three cutting management levels M1 : No cutting (Top dressing at 30 DAS),M2 : One cutting at 40 – 45 DAS (T.D. after first cut) and M3 : Two cutting at 40 – 45 DAS and 60-65 DAS (T.D.after each cut) in main plot and three fertility levels viz.,F1:20:10:00 kg NPK/ha, F2 : 40:20:00 kg NPK/ha and F3 : 60:30:00 kg NPK/ha in sub plot were replicated thrice in split plot design. All the growth and yield attributing characters of coriander were significantly influenced by cutting management, varieties and fertility levels on pooled basis. Cutting management, varieties and fertility levels affected significantly on coriander seed equivalent yield. One cutting at 45 DAS recorded significantly the higher coriander seed equivalent yield during course of investigation and on pooled basis over rest of the treatments.Variety GDLC 1 proved significantly superior than GCo 2 and produced higher coriander seed equivalent yield during individual as well as on pooled basis.Application of 60:30:00 kg NPK / ha produced significantly the highest coriander seed equivalent yield during individual years as well as on pooled basis. Interaction effect of cutting management, variety and fertility levels was found significant on coriander seed equivalent yield. Variety GDLC 1 cultivated by adopting two cutting at 40-45 DAS and 60-65 DAS (T.D.after each cut) supplemented the 60:30:00 kg NPK / ha recorded significantly the highest seed yield over rest of the different variety, cutting and fertility levels combinations.Variety GDLC 1 adopted with one cutting at 40 - 45 DAS (T.D. after first cut supplemented 60:30:00 kg NPK / ha achieved higher net realization (Rs.1,21,558 / ha) and BCR (3.2) value than rest of the combinations.
Malignant Pleural Effusion Secondary to Clear cell Renal Cell Carcinoma- A Case Report
Authors: Jha Ashutosh , Vishwanath Meghashree , Sinnarajah Prakashiny , Rajavel Prathipaa , Rajasekaran Pavithra , Vedachalam Ramamoorthy 
Published: August 2024

Renal cell carcinoma is the most common renal neoplasm. Its presentation is often very occult, and it may be discovered incidentally. It may present with the classic symptoms of back pain, flank pain, hematuria, or hypertension. Renal cell carcinoma may also present with malignant pleural effusion at diagnosis; however, it is very rare. Pleural effusion secondary to renal cell carcinoma constitutes only about 1% to 2% of all malignant pleural effusions. We report a case of 55-year-female who was a known case of Right side Renal cell carcinoma post operated and on chemotherapy suddenly presented in emergency department with breathlessness and chest pain. Chest X-ray demonstrated right-sided moderate pleural effusion; computed tomography (CT) reported bilateral effusion in the pleural cavity. CT-guided pleural thoracocentesis was performed. Cytology and cell block morphology showed clear cell type malignant tumor, leading to diagnosis of clear cell carcinoma in pleural fluid secondary to clear cell renal cell carcinoma. The study aim to discuss the Malignant pleural effusion secondary to Clear cell Renal cell carcinoma.
Perception of Noise Generated in Dental Offices as an Occupational Hazard -A Questionnaire Based Study.
Authors: M Jasmine Crena , Sanjeev Kavitha , Agarwal Akanksha 
Published: August 2024

Background: World Health Organization stated that “noise must be recognized as a major threat to human well-being.” The operating tools commonly used in dental clinics such as airotor, micro motor, sonic and ultrasonic scalers, compressor, suction generate potential noise which has hazardous effects on the dentist, dental assistants/technicians and also patients, resulting in both auditory and non-auditory effects.
Aim: The aim of the present study is to assess the knowledge and Awareness of Noise Pollution Generated in Dental Care Facilities among Clinicians using a structured questionnaire in-order to sensitize the dental fraternity on the importance of preventing occupational hazards.
Materials and Methods: Informed Consent was obtained from 100 voluntary dental professionals and information regarding their knowledge and awareness towards noise pollution in dental clinics was obtained by a self-made structured questionnaire comprising 22 questions. The Data was compiled and analysed with SPSS 22 software.
Results: The study population consisted of 31 male and 69 female dentists, out of which 85% perceived noise in dental operatory as an occupational hazard in terms of annoyance factors like tinnitus, difficulty in focussing and headache. Only 57.1% of the subjects were aware of the Maximum permissible levels of noise in a dental set up. Around 74.3% of the subjects have taken measures for noise reduction in practice, most common among them is placing compressors outside the clinic (28%).
Conclusion: In the era of digitalisation, we face numerous consequences in our workplace due to noise. This study has thrown insights on the general awareness levels of Noise induced Occupational Hazard among dentists which is not very satisfactory, and thus necessary steps need to be followed to combat such factors which may have long term effects like Tinnitus, Headache. Dentists at the least must avoid other noise producing hazardous activities and switch to noise free environments as much as possible.