bluuebunny/crossref_metadata_2025_split huggingface dataset:
O-194 SELF-SAMPLING IN HUMAN MONITORING
Authors: Godderis Lode , Verscheure Eline , De Ryck Evi , Daenen Liesbeth , Van den Brande Whitney , Vandenbroeck Sofie , Vanacker Hilde , Ghosh Manosij 
Published: July 2024

Abstract

Introduction
Health surveillance is an important means in preventive medicine which requires human effort. With the increasing shortage of healthcare workers, we are investigating the feasibility to implement self-sampling techniques for continuous remote monitoring.

Methods
An overview of methods has been collected through literature and feasibility studies have been set up to assess the factors influencing successful implementation.

Results
We distinguish two main types of available techniques: self-tests and self-collection tests. With a self-test the worker performs the entire process of collection and interpretation of data, such as apps to assess irregularities in heart rhythm, sleep pattern, physical activity, respiratory rate and skin health. Other examples are online platforms connected with wearables that monitor mental health providing immediate feedback. Emerging technologies are extended reality and chatbots, which still experience important limitations on data security and validity. With self-collection tests a person collects the sample and sends it to the laboratory for analysis, such as volumetric absorptive microsampling that allows collection of human tissues in a minimal invasive way. Urine, saliva and oral buccal cells are promising matrices for simple, rapid and non- or minimally invasive sample collection and can be used for the analysis of a wide range of biomarkers.

Discussion
Self-sampling is a convenient, cost-effective screening strategy. Ethical and juridical aspects are important points to consider.

Conclusion
Finally, health management platforms including electronic medical file, integrating wearable, sensor and app interfaces are required in combination with human interaction, empathy and trust to guarantee positive user experiences and validated measurements in an uncontrolled real-world.
P-341 COMPREHENSIVE EVALUATION OF CARCINOGENIC BIOMARKERS: URINARY 1-HYDROXYPYRENE IS THE MOST EFFECTIVE MARKER OF POLYCYCLIC AROMATIC HYDROCARBONS EXPOSURE
Authors: Yamano Yuko , Hara Kunio , Ichiba Masayoshi , Yamauchi Takenori , Okubo Shigeko , Hanaoka Tomoyuki 
Published: July 2024

Abstract

Introduction
Polycyclic aromatic hydrocarbons (PAHs) include many carcinogens. We conducted a cross- sectional study in a steel plant to identify biomarkers that reflect the carcinogenicity of PAHs.

Methods
Subjects were 57 workers and 20 controls. Personal exposure levels were measured using GC-MS, and urinary metabolites were treated with β-glucuronidase followed by High Performance Liquid Chromatography analysis with fluorescence detection.

Results and Discussion
Personal exposure levels to 15 PAHs (Total-PAHs) ranged from 47.08 to 1,329.45 µg/m3, with a mean of 178.85 µg/m3 (geometric mean, 5th, and 95th percentile). Analysis of urinary metabolites detected 10 known compounds, including 1-hydroxynaphthalene, 2-hydroxynaphthalene, 2-hydroxyfluorene, and others, along with four unknown peaks. The highest correlation was found between Total-PAHs and urinary 2- hydroxynaphthalene (Spearman r = 0.716, P &lt; 0.01). Notably, urinary 2-hydroxyfluorene, 1-hydroxyphenanthrene, 3-hydroxyphenanthrene, and 1-hydroxypyrene showed significant correlations with the “Σ carcinogenic potency of PAHs,” with the most significant association observed for 1-hydroxypyrene (Spearman r = 0.630, P &lt; 0.01).

Conclusions
Urinary 1-hydroxypyrene was identified as the most comprehensive carcinogenic biomarker for assessing PAH exposure. This study emphasizes the importance of monitoring PAH exposure levels and their potential health risks among steel plant workers.
P-342 ENDOCRINE DISRUPTION AND SLEEP PATTERNS IN VULNERABLE POPULATIONS
Authors: Teixeira Liliane , Coutinho Gilvania , Santos Marcus Vinicius Dos , da Rodrigues Vidal Vidal Priscila Jeronimo Silva , Azevedo Tatiana , Silva Ana Paula , Mattos Dominique , Victorino Fernando , Gonçalves Eline , De Carvalho Leandro , Rosa Ana Cristina , Larentis Ariane , De Andrade Carlos Augusto , Costa-Amaral Isabele , Friedrich Karen , Gomes Luciana , de Moreira Maria Fátima , Borges Renato , Pavesi Thelma , Fischer Frida Marina 
Published: July 2024

Abstract

The objective is to present and discuss results demonstrating the influence of chemicals exposure on the sleep patterns of workers and residents of industrial surroundings.

Materials and Methods
A cross-sectional study was conducted with 189 residents and 66 endemic workers. Health, work, Pittsburgh Sleep Quality Index (PSQI), actimetry, clinical, toxicological tests (metals, BZN, and TLN) and genotyping were performed.

Results and discussion
Study 1: 47% of the participants were afternoon chronotype, 42% were indifferent, and 11% were morning chronotype. Higher urinary Mn levels were associated with the morning chronotype (p &lt; 0.01). The evening chronotype was associated with poorer sleep quality, higher Pb levels, and BZN and TLN levels (p &lt; 0.01) in non-occupationally exposed individuals (p &lt; 0.01). Moreover, most participants (57%) reported poor sleep quality, and higher Cd levels in residents with higher scores for daytime dysfunction (p = 0.01) and sleep disturbance (p &lt; 0.01); Mn (p &lt; 0.01) and Ni (p = 0.03), for sleep disturbance; and TLN, for sleep duration (p &lt; 0.05). Study2: The mean sleep quality was 7.8 points (PSQI score) and 60% of the population was unhealthy sleep (PSQI &gt; 5). In addition, sleep duration was 5-6 hours, sleep efficiency was 80%, and the WASO was approximately 60 minutes. Stability and variability were 0.48-0.80 respectively, and positive correlation observed between the hormone Free T4 and sleep duration (p &lt;0.05). And the intraday variability had a negative correlation with hormone levels.

Conclusion
Exposure to contaminants influenced sleep patterns and the different chronotypes in the population exposed to toxic substances.
P-343 CORRELATION BETWEEN BLOOD LEAD LEVEL (BLL), VITAMIN D LEVEL WITH STRESS OXIDATIVE PARAMETER: A CROSS SECTIONAL STUDY ON LEAD EXPOSED WORKERS IN JAVA, INDONESIA
Authors: Mutiara Ade , Mansyur Muchtaruddin , Arozal Wawaimuli , Baskoro Muhammad Orri , Yuliani Dini 
Published: July 2024

Abstract

Introduction
In Indonesia, many Used Lead Acid Battery smelters operated by informal sector workers pose a potential health risk of metabolic and cardiovascular disorders through the oxidative stress mechanism and vitamin D deficiency due to chronic lead exposure. This study is aimed at analyzing the correlation of workers blood lead level (BLL), 25(OH)D level and Malondialdehyde (MDA) level as one of stress oxidative parameters, and Vitamin D level in Java Indonesia.

Material and Method
A total of 52 informal workers were consecutively selected from two regions in Java, one region with chronic and the other with non-chronic lead exposure. Venous blood samples were collected and analyzed for blood lead levels using ICP-MS, 25(OH)D with Elisa and MDA level using spectrophotometry with Will’s method.

Result and discussion
This study analyzes the correlation between groups with BLL &lt;10 µg/dL and &gt;10 µg/dL with the level of MDA (nmol/mL). We found that higher BLL has significantly lower MDA mean (BLL&lt;10 mean 1.07, BLL&gt;10 mean 0.59, P&lt;0.01) on the region that has chronic lead exposure. MDA sub-analysis showed a significant difference in MDA mean between the two regions (1.31 vs 0.51, p&lt;0.01). The analysis revealed a significant negative linear relationship between BLL and MDA (p &lt; 0.01). No significant relationship was found between 25(OH)D and MDA (p &gt; 0.01).

Conclusion
There is a significant negative linear relationship between MDA levels and BLL. We hypothesize the distinguish of this findings and other studies because the population with chronic lead exposure will lead to reduce physiological response to BLL compared to other region.
P-345 BIOMONITORING FOR EXPOSURE ASSESSMENT TO STYRENE IN THE FIBREGLASS REINFORCED PLASTIC INDUSTRY
Authors: Teixeira Joao , Costa Solange , Silva Susana Pinho e , Costa Carla 
Published: July 2024

Abstract

Introduction
Occupational exposure to styrene occurs in the styrene-butadiene rubber, styrene monomer and polymerisation, and reinforced plastics industries. Although the genotoxic potential of styrene is known, very limited and inconclusive information is available regarding its dose-dependent genotoxic effects in humans. The objective of this work was to study occupational exposure to styrene in a multistage approach, in order to integrate the following end-points studied: styrene in workplace air, mandelic and phenylglyoxylic acids (MA+PGA) in urine, Hb adducts, SCE, MN, DNA damage and genotypes of polymorphic genes of some metabolising enzymes.

Method
Seventy-five workers from a fibreglass-reinforced plastics factory and 77 unexposed controls took part in the study.

Results and Discussion
The mean air concentration of styrene in the breathing zone of workers was higher than the threshold limit value recommended by the ACGIH, and the BEI adopted by the ACGIH for exposure to styrene was exceeded, indicating that styrene exposure for this group of workers was higher than recommended. The level of Hb adducts and SCE in exposed workers were significantly increased as compared with controls. The DNA damage was higher among styrene-exposed workers than in controls. Concerning the effect of the genetic polymorphisms on the different exposure and effect biomarkers studied, we observed the effect of microsomal epoxide hydrolase activity on Hb adducts of highly exposed individuals and on the levels of SCE of exposed workers.

Conclusion
The present results suggest the importance of individual susceptibility factors in modulating genotoxicity, although cautious interpretations are required since the size of the study population limits the power of many of the analyses.
P-346 SCREENING FOR SIOC IN WORKERS EXPOSED TO ORGANIC SOLVENTS IN THE AUTOMOTIVE PARTS INDUSTRY
Authors: Gaaliche Imen , Ismail Saloua , Baraketi Emna , Merghni Syrine , Khouja Nihel , Bechrifa Emna , Fatma Naourez Ben , Meskini Cheima , Belkahla Amira , Khaiereddine Donia , Hsinet Jihen , Benzarti Aida 
Published: July 2024

Abstract

Introduction
Multiple chemical sensitivity syndrome (MCS) is defined as a group of nonspecific symptoms presented by a person exposed to various chemicals. Objectives: To screen for MCS and assess their impact on workers in the automotive parts manufacturing sector.

Methods
Cross-sectional and descriptive study conducted in an automotive parts manufacturing company in Ben Arous using the Quick Environmental Exposure and Sensitivity Inventory (QEESI).

Results
We recruited 120 employees, with an average age of 36,4 years. One hundred and one employees (84,2%) were exposed to organic solvents. One hundred employees (98,3%) developed symptoms of MCS during their professional careers, which were cognitive in 75% of cases and neurological in 45,8% of cases. The diagnosis of MCS was very likely in 29 employees (24,2%), fairly likely in eight employees (6,7%), unlikely in 78 employees (65%), and doubtful in five employees (4.2%). A fair or very likely MCS was significantly associated with a median duration of exposure to chemicals greater than ten years (p=0,001), the absence of regular wearing of personal protective equipment (p=0,00), and the presence of an anxiodepressive disorder (p=0,009) and absenteeism (p=0.00). Twenty-one employees (17.5%) benefited from job transfer.

Discussion
Because of the symptomatology, MCS has significant psychosocial and professional repercussions.

Conclusion
Early diagnosis of MCS is important to assess its impact and prevent deterioration of quality of life.
P-348 SUBJECTIVE SYMPTOMS AND SERUM MARKERS OF INFLAMMATION IN DENTAL TECHNICIANS
Authors: Okubo Shigeko , Yamauchi Takenori , Yamano Yuko 
Published: July 2024

Abstract

Introduction
Dental technicians are medical technology professionals responsible for the preparation of crown restorations and prosthetics, and the possibility that they may experience respiratory dysfunction due to the inhalation of metal fumes during dental laboratory work has been raised. In this study, we surveyed dental technicians for subjective symptoms and measured serum levels of inflammatory cytokines.

Methods
Forty subjects were investigated. The survey items included subjective symptoms and smoking history using the Japanese version of the ATS-DLD Standard Questionnaire for Respiratory Symptoms. Serum inflammatory cytokines such as TNF-α, IL-6 and 8-OHdG were also measured. The study was approved by the Ethics Committee of Showa University (approval number 2994).

Results
The number of years of employment (mean, range) was 20.4 (0.5-50) years. The most frequently reported respiratory symptoms was nasal congestion (35.0%). Nine patients (22.5%) had no subjective symptoms. Inflammation markers TNF-α (reference value 0.6-2.8 pg/ml) and IL-6 (reference value 8.0 pg/ml) were below the reference values in all subjects. None of the subjects showed elevated levels of 8-OHdG. However, a significant positive correlation was observed between the number of years of employment and TNF-α levels.

Discussion and Conclusion
About 80% of the dental technicians had some subjective symptoms of respiratory dysfunction, but most of the inflammatory markers and 8-OHdG were below standard values. TNF-α levels tended to be higher with longer working years, suggesting a higher risk of inflammation with longer working years.
P-351 CORRELATION BETWEEN SERUM 25(OH)D AND BLOOD LEAD LEVELS TO DELTA-AMINOLEVULINIC ACID DEHYDRATASE IN LEAD-EXPOSED WORKERS
Authors: Fadhillah Ratih , Ilyas Muhammad , Liem Jen Fuk , Khoe Levina Chandra , Mansyur Muchtaruddin 
Published: July 2024

Abstract

Introduction
Lead inhibits the heme synthesis pathway by altering the Delta-Aminolevulinic Acid Dehydratase (ALAD) activity, resulting in oxidative stress. Apart from its classic role, vitamin D also acts as an antioxidant, but lead exposure can also inhibit the process of converting 25(OH)D, resulting in a decrease in vitamin D levels. The aim of this study was to determine the correlation between serum 25(OH)D and blood lead level (BLL) to delta-ALAD activity.

Methods
We conducted a cross-sectional study and a total of 71 male workers occupationally exposed to lead in Java, Indonesia, were included in the initial analysis. Serum 25(OH)D, BLL, and ALAD activity were measured in the laboratory using ECLIA, ICP-MS, and spectrophotometry, respectively.

Results
There is no correlation was observed between serum 25(OH)D and ALAD activity. However, a moderate negative correlation was found between BLL and ALAD activity (r = -0.43, p&lt;0.001), and between BLL/25(OH)D ratio to ALAD activity (r = -0.44, p=0.001).

Discussion
As vitamin D is believed to act as an antioxidant, the correlation between BLL/25(OH)D ratio to ALAD indicated that a higher lead exposure induced lower 25(OH)D concentrations.

Conclusion
Higher BLL was correlated to lower ALAD activity. Our results also highlighted the potential of lead exposure to alter ALAD activity through decreased serum 25(OH)D. It is necessary to conduct further investigation using more precise and varied data. Keyword: Blood lead levels, Delta Aminolevulinic Acid Dehydratase, Lead exposure, 25(OH)D
P-356 TRIGEMINAL NEURITIS ASSOCIATED WITH CHRONIC OCCUPATIONAL EXPOSURE TO TRICHLOROETHYLENE
Authors: Fatma Naourez Ben , Hsinet Jihen , Khouja Nihel , Baraketi Emna , Bechrifa Emna , Belkahla Amira , Ismail Saloua , Benzarti Aida 
Published: July 2024

Abstract

Introduction
Trichlorethylene is a solvent widely used in many professional sectors, notably the chemical industry. However, it can be the cause of neurological disorders, especially trigeminal neuritis. Objectives: To study the clinical and paraclinical characteristics of trigeminal neuritis cases in relation to occupational exposure to trichloroethylene.

Methodology and Results
Five cases of trigeminal neuritis related to occupational exposure to trichlorethylene have been identified. All patients were male working in the chemical industry. The average age was 49.2 year.The chemical industry was the main source of trichlorethylene-related peripheral neuropathy. The average delay between the onset of symptoms and work activity was 15 years. The symptoms were dominated essentially by facial hypoesthesia. Somatosensory evoked potentials were performed in all patients and revealed bilateral trigeminal neuritis in four cases and unilateral trigeminal neuritis in one case. These cases were recognized as an occupational disease according to the regulations of the Tunisian list of compensable occupational diseases.

Discussion
Trichlorethylene toxic neuropathy is a rare condition with polymorphous clinical manifestations dominated by facial hypoesthesia. The study of somatosensory evoked potentials is of great diagnostic value.

Conclusion
Occupational exposure to trichlorethylene warrants regular medical supervision for early detection of this neuritis, as well as the reinforcement of technical prevention, which remains the only means of reducing this chemical risk.
O-197 COVID-19 AND HEALTH AND SAFETY OF THE DIGITAL EDUCATORS: A CASE STUDY OF BANGLADESH
Authors: Khan Tauhid Hossain , MacEachen Ellen , Sultana Ishrat Zakia , Khan Tauhid Hossain , MacEachen Ellen , Sultana Ishrat Zakia 
Published: July 2024

Abstract

Introduction
The COVID-19 pandemic led to significant changes in the education sector worldwide, forcing schools to shift to remote online teaching. As such, the digital teaching introduced unique occupational health stressors that posed a threat to the wellbeing of educators in Bangladesh. While much attention has been given to the quality of education, there is a lack of understanding regarding the impact on teachers’ lives and wellbeing. The study aimed to identify specific health risks and needs related to the transition to digital teaching.

Methods
Six Focus Group Discussions (n=48) were conducted to solicit the (primary and high school) teachers’ and tutors’ experiences of digital teaching. Using purposive sampling strategies, we recruited participants from different groups, including genders, rural and urban settings, and many more.

Results
The findings reveal the dynamics of challenges the teachers encountered, which included the blurring work-life, competing responsibilities (e.g.,caregiving), dual burden (e.g., household chores) for females while teaching remotely, access and learning new technology (e.g., technostress), anxiety stemming from salary suspension or job loss. However, many expressed a positive outlook because of the convenience of commuting to schools amidst traffic jams.

Discussion
In Bangladesh, neither Labor laws nor recently developed (2013) occupational health and safety (OHS) policies do not cover schoolteachers’ OHS. As the Ministry of Education has no specific guidelines, it is high time to identify occupational health risks exposed to digital educators.

Conclusion
Digital educators face numerous health-related challenges that need to be communicated with the existing policies to understand the gaps between policy and practice.
O-200 OCCUPATIONAL SAFETY AND HEALTH PRACTICES IN AN AGRICULTURAL COMPANY IN PIURA, PERU
Authors: Mera Chu Norvil Antonio 
Published: July 2024

Abstract

Objectives
Describing the implementation of the Occupational Safety and Health (OSH) System and its progressive improvement during 4 years in an agricultural company in Peru.

Material & Methods
This research was a case report study. The unit of study was the indicators of OSH programs and procedures executed at an agricultural company, related to OSH activities as training programs, risk assessment, designing new methods for working, changing job schedules, involving workers in safety inspections, providing adequate personal protection equipments (PEE), medical examinations for workers, internal audits, among others. Besides, it was analyzed the impact of the OSH system on the frequency of accidents and illnesses in workers, on the frequency of Covid-19 cases and other infectious diseases (including dengue fever), on absenteeism, the level of use of the PEE, on labor inspections and audits for certification, on getting clients, etc.

Results
The frequency of accidents was reduced in 22%. The frequency of diseases and comorbilities was reduced in 18%. Absenteeism was reduced in 26%. There were 2 new methods for working, and a new schedule and distribution of activities during day and night-shift. The enterprise got its Management System (which includes OSH) certified and got more clients every year, so the company exported more fruit, which implied more economic gains.

Discussion and Conclusion
It was a good investment to implement and improve the OSH system in this company, improving working conditions for rural population and bringing good income results for the company management, too.
P-372 SETTING UP SOCIMED, AN OCCUPATIONAL HEALTH AND SAFETY AND DATA ANALYSIS COMPANY IN DJIBOUTI
Authors: Isman Mohamed Omar , Gasana Janvier , BENNACER Benali 
Published: July 2024

Abstract

Introduction
Socimed.Sarl is the first national occupational safety and health (OSH) company specializing in OSH training of nurses and doctors, data analysis, and Project management/evaluation. Objective To offer OSH training with a certificate in collaboration with Faculty of Medicine of Djibouti, Higher Institute of Health Sciences, Hope Medical Polyclinic, and Mutualis Medical Center.

Methods
SOCIMED consultants offer doctoral and high-level engineering training and solid technical bases. Participants receive continuous training in OSH methods, project management/evaluation, and data analysis.

Results
The team of SOCIMED consultants has medical specialists (occupational physician and cardiologist) and Other OSH and Data Analysis professionals. Health and Safety Committee (HSC) is a legal obligation according to the labor code of Djibouti, and SOCIMED helps to comply with it. Business legal obligations for setting up a medical unit vary according to the number and category of the establishment.

Discussion
The World Health Organization (WHO) defines a minimum of services that each country must provide in terms of primary prevention and occupational health. WHO emphasis in occupational health is on strengthening surveillance, the assessment of the burden of occupational health, the development of a data system by country, in order to better support occupational health policies and action plans at the national level.

Conclusion
All companies are required by law to provide their employees with nursing care in the event of an accident at work. The company nurse carries out his duties in collaboration with doctors. This medical infrastructure allows rapid intervention in the event of an emergency and is also essential for prevention.