bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diurnal suppression of EGFR signalling by glucocorticoids and implications for tumour progression and treatment
Authors: Lauriola Mattia , Enuka Yehoshua , Zeisel Amit , D’Uva Gabriele , Roth Lee , Sharon-Sevilla Michal , Lindzen Moshit , Sharma Kirti , Nevo Nava , Feldman Morris , Carvalho Silvia , Cohen-Dvashi Hadas , Kedmi Merav , Ben-Chetrit Nir , Chen Alon , Solmi Rossella , Wiemann Stefan , Schmitt Fernando , Domany Eytan , Yarden Yosef 
Published: October 2014

AbstractSignal transduction by receptor tyrosine kinases (RTKs) and nuclear receptors for steroid hormones is essential for body homeostasis, but the cross-talk between these receptor families is poorly understood. We observed that glucocorticoids inhibit signalling downstream of EGFR, an RTK. The underlying mechanism entails suppression of EGFR’s positive feedback loops and simultaneous triggering of negative feedback loops that normally restrain EGFR. Our studies in mice reveal that the regulation of EGFR’s feedback loops by glucocorticoids translates to circadian control of EGFR signalling: EGFR signals are suppressed by high glucocorticoids during the active phase (night-time in rodents), while EGFR signals are enhanced during the resting phase. Consistent with this pattern, treatment of animals bearing EGFR-driven tumours with a specific kinase inhibitor was more effective if administered during the resting phase of the day, when glucocorticoids are low. These findings support a circadian clock-based paradigm in cancer therapy.
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
Authors: Babur Özgün , Gönen Mithat , Aksoy Bülent Arman , Schultz Nikolaus , Ciriello Giovanni , Sander Chris , Demir Emek 
Published: October 2014

AbstractRecent cancer genome studies have identified numerous genomic alterations in cancer genomes. It is hypothesized that only a fraction of these genomic alterations drive the progression of cancer – often called driver mutations. Current sample sizes for cancer studies, often in the hundreds, are sufficient to detect pivotal drivers solely based on their high frequency of alterations. In cases where the alterations for a single function are distributed among multiple genes of a common pathway, however, single gene alteration frequencies might not be statistically significant. In such cases, we expect to observe that most samples are altered in only one of those alternative genes because additional alterations would not convey an additional selective advantage to the tumor. This leads to a mutual exclusion pattern of alterations, that can be exploited to identify these groups.We developed a novel method for the identification of sets of mutually exclusive gene alterations in a signaling network. We scan the groups of genes with a common downstream effect, using a mutual exclusivity criterion that makes sure that each gene in the group significantly contributes to the mutual exclusivity pattern. We have tested the method on all available TCGA cancer genomics datasets, and detected multiple previously unreported alterations that show significant mutual exclusivity and are likely to be driver events.
Interdisciplinary accounting research in the Public Sector
Authors: Jacobs Kerry , Cuganesan Suresh 
Published: October 2014

Purpose– The purpose of this paper is to review and present a contemporary perspective on interdisciplinary accounting research in the context of the public services.Design/methodology/approach– The authors present the experience, interpretations and perspective on the state of this research and how it might usefully proceed. The authors use the concept of knowledge production modes to inform the discussion on how the authors might tackle wicked problems.Findings– The interdisciplinary accounting research project in the public services needs to do more in terms of moving outside the disciplines of accounting scholarship. Shifting to a mode of knowledge production that addresses wicked problems requires the interdisciplinary accounting project to work on specific problems with real world application. The authors must re-envision how the work with practice in the doing of research.Originality/value– This timely perspective argues for a transition in the interdisciplinary accounting research project in the public services before its approach, assumptions and methods become taken-for-granted, potentially missing this opportunity to shift into a more engaged research enterprise.
Realizing the potential of interdisciplinarity in accounting research
Authors: O’Dwyer Brendan , Unerman Jeffrey 
Published: October 2014

Purpose
– The purpose of this paper is to explore the meaning of interdisciplinarity in accounting research and the possible benefits of moving toward a more integrated interdisciplinary approach. It also examines the drawbacks and institutional impediments to such a move.

Design/methodology/approach
– The paper draws upon and synthesizes the authors’ experiences of involvement in the interdisciplinary accounting community over the past two decades.

Findings
– The paper distinguishes between interdisciplinarity at the field level and interdisciplinarity within individual studies. Noting a lack of study-level interdisciplinarity within accounting research, it explores the potential for novel insights emerging from encouragement of such an approach.

Research limitations/implications
– Institutional impediments to study-level interdisciplinarity need to be addressed if the accounting academy is to realize the potentially powerful benefits and social contribution of such an approach to research. A key limitation is that the paper is based primarily on the observations and perspectives of the authors.

Originality/value
– The paper provides a distinction between field-level and study-level interdisciplinarity.
Coarticulation and speech synchronization in MPEG-4 based facial animation
Authors: Leandro Parreira Duarte Ricardo , El Rhalibi Abdennour , Merabti Madjid 
Published: October 2014

Purpose– The purpose of this paper is to present a novel coarticulation and speech synchronization framework compliant with MPEG-4 facial animation (FA).Design/methodology/approach– The system the authors have developed uses MPEG-4 FA standard and other development to enable the creation, editing and playback of high-resolution 3D models; MPEG-4 animation streams; and is compatible with well-known related systems such as Greta and Xface. It supports text-to-speech for dynamic speech synchronization. The framework enables real-time model simplification using quadric-based surfaces.Findings– The preliminary experiments show that the coarticulation technique the authors have developed gives overall good and promising results when compared to related techniques.Originality/value– The coarticulation approach provides realistic and high performance lip-sync animation, based on Cohen-Massaro's model of coarticulation adapted to MPEG-4 FA specification.
Service branding: suggesting an interactive model of service brand development
Authors: Skaalsvik Hugo , Olsen Bjørn 
Published: October 2014

Purpose– The purpose of this paper is to suggest an interactive model of service brand development.Design/methodology/approach– The design employed in the research represents a holistic and systemic approach to services branding and the methodology employed is conceptual desk research.Findings– The research findings encompass an interactive model of service brand components grounded on a systemic perspective. By building on services brand theory, three key actors constitute the components of the model, namely service leadership, service employees and customers. The findings also state how successful service branding may be obtained at the level of the individual service enterprise.Practical implications– The paper outlines a set of practical implications. For example, successful service brand development is obtained through a high degree of service orientation, customer involvement, an involvement model of service leadership and a motivated, committed and empowered workforce, particularly those employees at the frontline.Originality/value– The originality and value of the research rests on using systemic thinking in the development of an interactive model of services brand development
Phylogenetic diversity and co‐evolutionary signals among trophic levels change across a habitat edge
Authors: Peralta Guadalupe , Frost Carol M. , Didham Raphael K. , Varsani Arvind , Tylianakis Jason M. 
Published: October 2014

Summary

Incorporating the evolutionary history of species into community ecology enhances understanding of community composition, ecosystem functioning and responses to environmental changes.

Phylogenetic history might partly explain the impact of fragmentation and land‐use change on assemblages of interacting organisms and even determine potential cascading effects across trophic levels. However, it remains unclear whether phylogenetic diversity of basal resources is reflected at higher trophic levels in the food web. In particular, phylogenetic determinants of community structure have never been incorporated into habitat edge studies, even though edges are recognized as key factors affecting communities in fragmented landscapes.

Here, we test whether phylogenetic diversity at different trophic levels (plants, herbivores and parasitoids) and signals of co‐evolution (i.e. phylogenetic congruence) among interacting trophic levels change across an edge gradient between native and plantation forests. To ascertain whether there is a signal of co‐evolution across trophic levels, we test whether related consumer species generally feed on related resource species.

We found differences across trophic levels in how their phylogenetic diversity responded to the habitat edge gradient. Plant and native parasitoid phylogenetic diversity changed markedly across habitats, while phylogenetic variability of herbivores (which were predominantly native) did not change across habitats, though phylogenetic evenness declined in plantation interiors. Related herbivore species did not appear to feed disproportionately on related plant species (i.e. there was no signal of co‐evolution) even when considering only native species, potentially due to the high trophic generality of herbivores. However, related native parasitoid species tended to feed on related herbivore species, suggesting the presence of a co‐evolutionary signal at higher trophic levels. Moreover, this signal was stronger in plantation forests, indicating that this habitat may impose stresses on parasitoids that constrain them to attack only host species for which they are best adapted.

Overall, changes in land use across native to plantation forest edges differentially affected phylogenetic diversity across trophic levels, and may also exert a strong selective pressure for particular co‐evolved herbivore–parasitoid interactions.
Ca2+/calmodulin dependent kinase II: A critical mediator in determining reperfusion outcomes in the heart?
Authors: Bell James R , Erickson Jeffrey R , Delbridge Lea MD 
Published: October 2014

SummaryIschaemic heart disease is a major cause of death and disability in the Western world, and a substantial health burden. Cardiomyocyte Ca2+ overload is known to significantly contribute to contractile dysfunction and myocyte death in ischaemia and reperfusion, and significant advancements have been made in identifying the downstream mediators and cellular origins of this Ca2+ mismanagement. Ca2+/calmodulin‐dependent kinase II (CaMKII) is recognized as an important mediator linking pathological changes in subcellular environments to modifications in cardiomyocyte Ca2+ handling. Activated in response to fluctuations in cellular Ca2+ and to various post‐translational modifications, CaMKII targets numerous Ca2+ channels/transporters involved in Ca2+ handling and contractile function regulation. CaMKII is activated early in reperfusion, where it exacerbates Ca2+ leak from the sarcoplasmic reticulum and promotes the onset of ventricular arrhythmias. Inhibiting CaMKII can increase functional recovery in reperfusion and reduce apoptotic/necrotic death, at least partly through indirect and direct influences on mitochondrial Ca2+ levels and function. Yet, CaMKII can also have beneficial actions in ischaemia and reperfusion, in part by providing inotropic support for the stunned myocardium and contributing as an intermediate to cardioprotective preconditioning signalling cascades. There is considerable potential in targeting CaMKII as a part of a surgical reperfusion strategy, though further mechanistic understanding of the relationship between CaMKII activation status and the extent of ischaemia/reperfusion injury are required to fully establish an optimal pharmacological approach.
Optimisation of sweetener and bulking agent levels for the preparation of functional Chhana‐murki
Authors: Gurditta Harsh , Patel Ashok A. , Arora Shalini 
Published: October 2014

A functional Chhana‐murki (FCM) was formulated at laboratory scale using different levels of microcrystalline cellulose (MCC): inulin (fibre) blend (1:1), isomalt:lactitol (polyol) blend (1:1), gum arabic and sucralose by response surface methodology (RSM) and sensory analysis. The colour and appearance, texture, flavour and overall acceptability scores increased by increasing the fibre level from 5 to 10% (w/w) and polyol level from 5 to 15% (w/w). The sweetness score increased significantly by increasing the sucralose level from 600 to 800 ppm (w/w). The optimised product had 738 ppm sucralose, 10% fibre, 15% polyol and 1.1% gum arabic.
Gender‐ and site‐specific differences of colorectal neoplasia relate to vitamin D
Authors: Aigner E. , Stadlmayr A. , Huber‐Schönauer U. , Zwerina J. , Husar‐Memmer E. , Niederseer D. , Trauner M. , Heuberger A. , Hohla F. , Schett G. , Patsch W. , Datz C. 
Published: October 2014

SummaryBackgroundThe effect of vitamin D on colorectal adenomas may vary with regard to gender, localisation and histological type of the lesion.AimTo define the role of vitamin D and gender in a Caucasian cohort of subjects undergoing screening colonoscopy after consideration of established risk factors.MethodsOne thousand five hundred and thirty‐two subjects (813 males, 58.8 ± 9.7 years; 719 females, 59.7 ± 10.7 years) were allocated to tertiles of 25‐hydroxyvitamin D3 [25(OH)D3] serum concentrations. The number, localisation, size and histology of the detected colonic lesions were recorded.ResultsAmong men, no association was found between vitamin D and the total number, size and histological stage of adenomas at any site. In female subjects, less women with adenomas were found in the highest vitamin D tertile (N = 42/239; 17.2%) as compared to the low vitamin D group (N = 60/240; 25.0%; P = 0.035). In particular, the number of women with adenomas in the proximal colon was significantly lower in the highest tertile (N = 21/239, 8.8%) compared to the low vitamin D group (N = 41/240; 17.1%; P = 0.007). The rates at other sites were not different. The inverse association of vitamin D serum concentrations with the presence of adenomas in the proximal colon was maintained after adjustment for potential confounders. In 80 women on vitamin D supplementation, the rate of adenomas was lower compared to those not on supplementation (3/80; 3.8%; vs. 90/719; 12.5%; P = 0.016).ConclusionsA potential preventive effect of vitamin D on colorectal adenomas was found in the proximal colon in women. This observation is supported by further decrease of lesions in the proximal colon of women on vitamin D supplementation.
Lower aldosterone–renin ratio is a risk factor for total and cancer death in Japanese individuals: the Takahata study
Authors: Daimon Makoto , Konta Tsuneo , Oizumi Toshihide , Kameda Wataru , Susa Shinji , Terui Ken , Nigawara Takeshi , Kageyama Kazunori , Ueno Yoshiyuki , Kubota Isao , Yamashita Hidetoshi , Kayama Takamasa , Kato Takeo 
Published: October 2014

SummaryObjectiveA higher plasma aldosterone–renin ratio (ARR) is an established marker for screening for primary aldosteronism (PA). The association between higher ARR and mortality in a general population has not been fully explored. We here examined whether higher ARR is a risk factor for total and cause‐specific mortality in a Japanese population.Subjects and MethodsA population‐based, longitudinal study of 1,310 Japanese individuals (age: 63·9 ± 9·8 years) enrolled in the Takahata study between 2004 and 2006 and followed for up to 8 years. The incidence and causes of death were monitored annually until 10 January 2012 (median follow‐up: 2691 days).ResultsDuring the follow‐up period, 64 subjects died. Kaplan–Meier analysis showed a significantly increased risk for total and cancer mortality in subjects with lower ARR (log‐rank P < 0·001). Cox's proportional hazard model analyses with adjustment for age and gender showed that lower ARR was associated with increased total and cancer mortality in subjects with low (≦72) vs high (>72) ARR (hazard ratios and 95% confidential intervals: 2·56, 1·44–4·56 and 2·78, 1·16–6·65, respectively).ConclusionsLower ARR was a significant and independent risk factor for increased total and cancer mortality in this Japanese population. Subjects with higher ARR were not‐at‐risk for total death in general. These findings increase the necessity for identifying people with PA from those with higher ARR. People with higher ARR without PA may be at very low risk for total and cancer death.
Relationships of serum lipid profiles and bone mineral density in postmenopausal Chinese women
Authors: Li Shuang , Guo Hongbing , Liu Youshuo , Wu Feng , Zhang Hongbing , Zhang Zhimin , Xie Zhongjian , Sheng Zhifeng , Liao Eryuan 
Published: October 2014

SummaryObjectivesRecent studies suggest that serum lipid profiles are related to bone mineral density (BMD). But data about this relationship on Chinese population are scarce. We investigated the relationships between serum lipid and BMD in postmenopausal Chinese women.MethodsA cross‐sectional study was conducted in 790 Chinese postmenopausal women. BMDs were measured by dual X‐ray absorptiometry. Serum lipid profiles were obtained after a 12‐h fasting.ResultsWomen with serum high‐density lipoprotein cholesterol (HDL‐C) levels of at least 1·55 mmol/l had a greater prevalence of osteoporosis compared with women with lower HDL‐C (≤1·54 mmol/l). After controlling for age, menopausal duration, body mass index, serum creatinine levels, outdoor activity, smoking and alcohol intake, high HDL‐C levels were associated with osteoporosis (OR = 1·64, 95%CI 1·16–2·33, P < 0·01). BMD at femoral neck and total hip was significantly lower in the higher HDL‐C class than the lower class (0·722 ± 0·118 vs 0·744 ± 0·120 g/cm2, P < 0·01; 0·800 ± 0·126 vs 0·824 ± 0·125 g/cm2, P < 0·01, respectively). No association was found between total cholesterol (TC), triglyceride (TG) and low‐density lipoprotein cholesterol (LDL‐C) with BMD.ConclusionsIn Chinese postmenopausal women, elevated levels of serum HDL‐C had a greater probability of being osteoporosis than the lower HDL‐C levels. Our analysis showed higher HDL‐C level that is favourable for cardiovascular diseases should be regarded as a risk factor for osteoporosis.
Do sensation differences exist between dental implants and natural teeth?: a meta‐analysis
Authors: Higaki Nobuaki , Goto Takaharu , Ishida Yuichi , Watanabe Megumi , Tomotake Yoritoki , Ichikawa Tetsuo 
Published: October 2014

AbstractObjectiveThe purpose of this systematic review was to survey evidence pertaining to the sensation differences between natural teeth and osseointegrated dental implants.Material and methodsUsing the MEDLINE (online PubMed) database, Cochrane Library, and Scientific Citation index, we performed a systematic search of articles. We used the following search terms: “perception or sensation and dental implant.” The systematic review of the extracted articles was performed to see the sensation differences between natural teeth and dental implants.ResultsA total of six studies on oral sensation, “tactile sensibility,” and “thickness discrimination” were included in the meta‐analysis. As to the “tactile sensibility”, all studies indicated the threshold levels of the implants were about 4–20 times higher than that of natural teeth. The tactile sensibility of an implant was significantly higher than that of a natural tooth, with an standardized mean difference (SMD) of 8.3619 (95% CI, 6.3920–10.3317) and a P < 0.0001. As to the “thickness discrimination”, all studies indicated the threshold levels of implants were about 1.2–2.3 times higher than that of natural teeth. The thickness discrimination was significantly higher than that of natural teeth with an SMD of 1.2368 (95% CI, 0.8699–1.6038) and a P < 0.0001.ConclusionThis meta‐analysis suggested that both tactile sensibility and thickness discrimination thresholds of implants were significantly higher than those of natural teeth. This meta‐analysis reconfirms that sensation differences between dental implants and natural teeth exist.
Lennox‐Gastaut syndrome: A consensus approach to differential diagnosis
Authors: Bourgeois Blaise F. D. , Douglass Laurie M. , Sankar Raman 
Published: October 2014

SummaryLennox‐Gastaut syndrome (LGS) is a severe epileptic encephalopathy that shares many features and characteristics of other treatment‐resistant childhood epilepsies. Accurate and early diagnosis is essential to both prognosis and overall patient management. However, accurate diagnosis of LGS can be clinically challenging. This article summarizes key characteristics of LGS and areas of overlap with other childhood epilepsies. Drawing upon input from a committee of established LGS experts convened in June 2012 in Chicago, Illinois, the authors highlight key diagnostic tests for making the differential diagnosis and propose a diagnostic scheme for people with suspected LGS.
The ecological effects of providing resource subsidies to predators
Authors: Newsome Thomas M. , Dellinger Justin A. , Pavey Chris R. , Ripple William J. , Shores Carolyn R. , Wirsing Aaron J. , Dickman Christopher R. 
Published: October 2014

AbstractAimPredators often have important roles in structuring ecosystems via their effects on each other and on prey populations. However, these effects may be altered in the presence of anthropogenic food resources, fuelling debate about whether the availability of such resources could alter the ecological role of predators. Here, we review the extent to which human‐provided foods are utilised by terrestrial mammalian predators (> 1 kg) across the globe. We also assess whether these resources have a direct impact on the ecology and behaviour of predators and an indirect impact on other co‐occurring species.LocationGlobal.MethodsData were derived from searches of the published literature. To summarise the data we grouped studies based on the direct and indirect effects of resource subsidies on predators and co‐occurring species. We then compared the types of predators accessing these resources by grouping species taxonomically and into the following categories: (1) domesticated species, (2) mesopredators and (3) top predators.ResultsHuman‐provided foods were reported to be utilised by 36 terrestrial predator species in 34 different countries. In the presence of these resources we found that: (1) predator abundance increased, (2) the dietary preferences of predators altered to include the food subsidy, (3) life‐history parameters such as survival, reproduction and sociality shifted to the benefit or detriment of the predator, and (4) predators changed their home ranges, activity and movements. In some instances, these modifications indirectly affected co‐occurring species via increased predation or competition.Main conclusionsThe availability of human‐provided food to predators often results in behavioural or population‐induced changes to predators and trophic cascades. We conclude that there is an urgent need to reduce the access of predators to food subsidies to minimise human–wildlife conflicts and to preserve the integrity of ecosystem functioning in human‐influenced landscapes world‐wide.