bluuebunny/crossref_metadata_2025_split huggingface dataset:
Centralization reduces meniscal extrusion, improves joint mechanics and functional outcomes in patients undergoing meniscus surgery: A systematic review and meta‐analysis
Authors: Boksh Khalis , E.T. Shepherd Duncan , M. Espino Daniel , Ghosh Arijit , Aujla Randeep , Boutefnouchet Tarek 
Published: August 2024

AbstractPurposeTo perform a systematic review and meta‐analysis of the existing literature on meniscal centralisation procedures, analysing its impact on meniscal extrusion, joint biomechanics and clinical and radiological outcome measures.MethodsThe Cochrane Controlled Register of Trials, PubMed (MEDLINE) and Embase were used to perform a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses criteria. Biomechanical studies on healthy animal or human cadaveric knee joints that assessed meniscal extrusion or tibiofemoral contact mechanics (contact area and pressure) following centralization for meniscal pathologies were included. For clinical studies, those that prospectively or retrospectively assessed patient‐reported outcome measures (PROMs), postoperative knee motion, complications and radiological extrusion following centralization for meniscal pathologies were included.ResultsFifteen studies were included in the analysis, comprising eight biomechanical, six clinical and one both. There were 92 knee specimens for biomechanical testing, of which 40 were human cadaveric and 52 porcine models. Biomechanical data revealed centralization to be commonly performed for posterior meniscal root tears and significantly reduced extrusion and contact pressure whilst improving contact area following a tear (p < 0.00001). Centralization restored extrusion to that of the native knee at all flexion angles described (0–90°, p = 0.25) and, compared to the torn state, brought tibiofemoral contact mechanics 3.2–5.0 times closer to the native state. Clinical data showed that 158 patients underwent centralization for extrusion. It improved postoperative Knee Injury and Osteoarthritis Outcome score (KOOS) (p = 0.006) and Lysholm scores (p < 0.00001) at 25.0 months, maintained extrusion reduction at 17.1 months (p < 0.00001) and preserved knee motion.ConclusionCentralisation for various meniscal injuries associated with extrusion can reduce meniscal extrusion and improve joint biomechanics, along with clinical and radiological outcomes. Existing evidence is still scarce and exhibits a notable amount of methodological heterogeneity.Level of EvidenceSystematic review of Level IV evidence.
Differential association of key bacterial groups with diatoms and Phaeocystis spp. during spring blooms in the Southern Ocean
Authors: West Nyree J. , Landa Marine , Obernosterer Ingrid 
Published: August 2024

AbstractInteractions between phytoplankton and heterotrophic bacteria significantly influence the cycling of organic carbon in the ocean, with many of these interactions occurring at the micrometer scale. We explored potential associations between specific phytoplankton and bacteria in two size fractions, 0.8–3 µm and larger than 3 µm, at three naturally iron‐fertilized stations and one high nutrient low chlorophyll station in the Southern Ocean. The composition of phytoplankton and bacterial communities was determined by sequencing the rbcL gene and 16S rRNA gene from DNA and RNA extracts, which represent presence and potential activity, respectively. Diatoms, particularly Thalassiosira, contributed significantly to the DNA sequences in the larger size fractions, while haptophytes were dominant in the smaller size fraction. Correlation analysis between the most abundant phytoplankton and bacterial operational taxonomic units revealed strong correlations between Phaeocystis and picoeukaryotes with SAR11, SAR116, Magnetospira, and Planktomarina. In contrast, most Thalassiosira operational taxonomic units showed the highest correlations with Polaribacter, Sulfitobacteria, Erythrobacter, and Sphingobium, while Fragilariopsis, Haslea, and Thalassionema were correlated with OM60, Fluviicola, and Ulvibacter. Our in‐situ observations suggest distinct associations between phytoplankton and bacterial taxa, which could play crucial roles in nutrient cycling in the Southern Ocean.
Does digital transformation increase corporate violations?
Authors: Wang Wanwan , Zhu Guoyiming , Mo Shenwei 
Published: August 2024

AbstractThis study examines whether digital transformation influences corporate violations in China. Using data from Chinese A‐share listed companies from 2007 to 2020, this paper finds that digital transformation increases the incidence of corporate violations. The results remain robust through endogeneity checks, the use of alternative measurements for digital transformation and corporate violations, and subsample analyses. Cross‐sectional analyses suggest that the impact of digital transformation on corporate violations is more salient in non‐state‐owned enterprises, firms with lower institutional investors shareholding ratios, and firms with higher agency costs. Mechanism analyses indicate that digital transformation leads to corporate violations by increasing operational complexity and affecting information quality. Additional tests reveal that effective corporate governance helps reduce the occurrence of corporate violations resulting from digital transformation. This research deepens our understanding of the economic implications of corporate digital transformation and provides valuable insights for businesses undergoing this process.
Information disclosure strategies of live‐streaming supply chains in the digi‐economy era
Authors: Ma Xiaoyong , Liu Shuai 
Published: August 2024

AbstractLive e‐commerce is one of the important forms of digital transformation of supply chain, which has become increasingly popular in recent years as a powerful tool for internet advertising, interaction, and merchandising. We propose two pricing models to examine the strategies of information disclosure and pricing within the live‐streaming supply chain. One model revolves around the agency framework, wherein the manufacturer determines the price while the streamer decides the level of information disclosure. The other model pertains to a self‐implementing framework, wherein the manufacturer determines both the level of information disclosure and the price. To evaluate the robustness of our findings, we extend our models to encompass three significant scenarios: (i) the platform involvement model, where a live‐streaming support platform becomes part of the supply chain; (ii) the fixed price model, which externalizes the manufacturer's pricing decision; and (iii) the dual‐channel operations model. Our analysis reveals that the cost associated with information disclosure impacts the streamer's profits in a nonlinear manner within the agency model. Interestingly, expanding the revenue‐sharing parameter does not invariably favor the manufacturer. Moreover, we observe that none of the live‐streaming sales models exhibits a clear advantage over the others. Additionally, we demonstrate that the platform's involvement limits the manufacturer's ability to utilize the agency model for live‐streaming sales. In situations with fixed pricing, the manufacturer is advised to disclose more production information during live‐streaming sales.
Chemography‐guided analysis of a reaction path network for ethylene hydrogenation with a model Wilkinson's catalyst
Authors: Gantzer Philippe , Staub Ruben , Harabuchi Yu , Maeda Satoshi , Varnek Alexandre 
Published: August 2024

AbstractVisualization and analysis of large chemical reaction networks become rather challenging when conventional graph‐based approaches are used. As an alternative, we propose to use the chemical cartography (“chemography”) approach, describing the data distribution on a 2‐dimensional map. Here, the Generative Topographic Mapping (GTM) algorithm ‐ an advanced chemography approach ‐ has been applied to visualize the reaction path network of a simplified Wilkinson's catalyst‐catalyzed hydrogenation containing some 105 structures generated with the help of the Artificial Force Induced Reaction (AFIR) method using either Density Functional Theory or Neural Network Potential (NNP) for potential energy surface calculations. Using new atoms permutation invariant 3D descriptors for structure encoding, we've demonstrated that GTM possesses the abilities to cluster structures that share the same 2D representation, to visualize potential energy surface, to provide an insight on the reaction path exploration as a function of time and to compare reaction path networks obtained with different methods of energy assessment.
Influence of temperature and internal leakage on magnetorheological damper
Authors: Zhu Hongtao , Rui Xiaoting , Yang FuFeng , Zhu Wei , Jiang Min 
Published: August 2024

AbstractTo study the influence of temperature and internal leakage on the performance of magnetorheological (MR) damper, a single‐rod straight‐cylinder MR damper with an inside temperature sensor is designed in this study. A unified model for MR damper is given, and a new two‐step parameters identification method is proposed to determine model parameters. The experiment, in which the damper is heated by long‐time displacement excitation, is designed to study the effect of temperature and internal leakage. The influence mechanism of temperature and internal leakage on MR damper is analyzed through theoretical derivation and experimental results in this study.
New randomized controlled trials on micronutrients in critical care nutrition: A narrative review
Authors: Halim Zakiah , Huang Yingxiao , Lee Zheng‐Yii , Lew Charles Chin Han 
Published: August 2024

AbstractThere has been increasing interest in the role of micronutrient supplementation in critical care. This narrative review summarizes the recent studies on micronutrients in critically ill patients. We searched two databases for primary randomized controlled trials that investigated the effects of micronutrient supplementation in patients with critical illness published from January 2021 to August 2023. Personal files, reference lists of included studies, and previous reviews were also screened. Twelve studies reported on vitamin C, four studies on vitamin D, three studies on thiamin, two studies on multivitamins, and one study on cobalamin. The therapeutic effects of vitamin C appear mixed, although vitamin C monotherapy appears more promising than vitamin C combination therapy. Intramuscular administration of vitamin D appeared to lower mortality, mechanical ventilation duration, and intensive care unit stay, whereas enteral administration showed limited clinical benefits. Intravenous thiamin was not associated with improved outcomes in patients with septic shock or hypophosphatemia. Preliminary evidence suggests reduced vasopressor dose with cobalamin. Decreased disease severity and hospital stay in patients with COVID‐19 with vitamins A–E requires further investigation, whereas providing solely B‐group vitamins did not demonstrate therapeutic effects. It is currently premature to endorse the provision of high‐dose micronutrients in critical illness to improve clinical outcomes. This review may help to inform the design of future trials that will help better elucidate the optimal dosage and form of micronutrients, methods of administration, and subgroups of patients with critical illness who may most benefit.
Optimal iterative learning control under varying iteration lengths with input saturation
Authors: You Mingchao , Shen Jie , Li Liwei , Shen Mouquan 
Published: August 2024

AbstractThis article is concerned with optimized iterative learning control of linear time‐invariant systems against input saturation and varying iteration length. The varying length is described by a stochastic form. The corresponding iteration output is modified by the combination of the real iteration output and the desired one with the varying consideration. To optimize the tracking error, the constraint caused by input saturation is transformed to an unconstraint structure by a barrier method. Newton's method based optimal control law is adopted to minimize the quadratic index related to a modified tracking error. Rigorous theoretical derivations are presented to guarantee the convergence of tracking errors. An example is provided to confirm the validity of the proposed approach.
The impact of congenital heart disease on treatment and survival of patients with hepatoblastoma: A single‐center experience
Authors: Espinoza Andres F. , Montgomery Ashley E. , Maamari Nicholas C. , Dickerson Heather A. , Heczey Andras , Vasudevan Sanjeev A. , Foster Jennifer H. 
Published: August 2024

AbstractBackgroundPatients with hepatoblastoma (HB) have a higher risk of congenital heart defects (CHD). There is limited literature on the management and outcomes of these patients. The purpose of this study was to identify demographics and outcomes of these patients in a single tertiary referral center.MethodsAn Institutional Review Board (IRB)‐approved retrospective chart review of patients with newly diagnosed HB from October 2004 to January 2021 was performed. CHD was defined as the presence of a septal defect, patent ductus arteriosus, pulmonary atresia, or bicuspid aortic valve. Chi‐square and t‐test were utilized for statistical analyses.ResultsOf the 151 patients diagnosed with HB during the study timeframe, 29 patients were found to have CHD. Five‐year overall survival (OS) for non‐CHD HB patients was 81.9% compared to 68.9% in the CHD cohort (p = .12). The 5‐year OS for patients without surgically intervened CHD was 63.6% compared to 70.5% for those with surgically repaired CHD (p = .88). Pre‐treatment extent of tumor IV was present more often in patients with HB and CHD who passed away (6/9, 66.7%) compared to those who survived (3/16,18.8%, p = .01).ConclusionsPatients with HB and CHD have similar survival compared to those without CHD. Our data support that patients with HB and CHD should be treated with curative intent including cardiac surgical intervention, medical oncology therapy, and oncological surgery for their HB.
Multimodality detection of tumour rupture in children with Wilms tumour
Authors: Dzhuma Kristina , Oostveen Minou , Watson Tom , Powis Mark , Vujanic Gordan , Saunders Daniel , Al‐Saadi Reem , Chowdhury Tanzina , Lopez Angela , Brok Jesper , Irtan Sabine , Williams Richard , Tugnait Suzanne , Shelmerdine Susan C. , Olsen Oystein , Pritchard‐Jones Kathy 
Published: August 2024

AbstractBackground and aimsTumour rupture (TR) signifies stage III disease and requires treatment intensification, which includes radiotherapy. We studied the associations between radiological, surgical and pathology TR in children with Wilms tumour (WT) in a United Kingdom multicentre clinical study.Patients and methodsThe IMPORT (Improving Population Outcomes for Renal Tumours of Childhood) study registered 712 patients between 2012 and 2021. Children with TR on central radiology review (CRR) at diagnosis and/or indication of preoperative TR on surgical forms were included. Correlation between radiology/surgery/pathology findings was made.ResultsTotal 141 patients had TR identified (69 on CRR, 43 on surgical form and 29 on both), and 124/141 had images available for CRR, and 98/124 had features suggestive of TR on diagnostic CRR (63 magnetic resonance imaging/35 computed tomography). TR was limited to the renal fossa in 47/98 (48%) and intraperitoneal in 51/98 (52%). Three of 98(3%) had upfront surgery, and 87/95 (92%) had TR confirmed on post‐chemotherapy preoperative scans. Among 80/98 (82%) cases with TR on CRR and available surgical forms, TR was not confirmed on surgery or pathology in 38/80, giving a false‐positive rate of 48%. Preoperative TR was indicated on 72 surgical forms, with images available for CRR in 55. Twenty‐six of 55 (47%) were false‐negative for TR on CRR and of those 10/26 (38%) had TR confirmed on pathology.ConclusionsRadiology alone should not be used to define TR, as it does not accurately correlate with surgical or pathology findings, and therefore cannot be relied upon for definitive staging and treatment. A multidisciplinary team should take the decision regarding the final abdominal stage and treatment using a multimodality approach considering clinical, radiological, surgical and pathological findings.
The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia
Authors: Taub Jeffrey W. , Buck Steven A. , Xavier Ana C. , Edwards Holly , Matherly Larry H. , Ge Yubin 
Published: August 2024

AbstractAn attractive flower from the island of Madagascar has in part saved the lives of thousands of children with acute lymphoblastic leukemia (ALL). Random mutations and alterations to the genome led to the evolution of genes encoding enzymes, which would provide the periwinkle flower an arsenal of secondary metabolites to survive within the Madagascar ecosystem. Of the over 200 alkaloid compounds synthesized by the periwinkle, vincristine and vinblastine are the two most well‐known being used for chemotherapy treatments, including for children with ALL. The complexities of the multi‐step biosynthesis of vincristine and vinblastine, which has taken years to decode, highlight the importance of protecting the vast biodiversity on earth as other natural products that can save lives await to be discovered. This review addresses the discovery of vincristine and vinblastine, as well as the history of their existence, in nature.
Risk of transfusion‐related iron overload varies based on oncologic diagnosis and associated treatment: Retrospective analysis from a single pediatric cancer center
Authors: Winzent‐Oonk Shelby , Staley Alyse , Alami Vida , Bradley Julie , Harvey Susan , Pounds Aneisia , Kuldanek Susan , Pacenta Holly , Winters Amanda C. , McKinney Chris 
Published: August 2024

AbstractBackgroundTransfusion‐related iron overload (TRIO) is a widely acknowledged late effect of antineoplastic therapy in pediatric cancer survivors, but firm guidelines as to screening protocols or at‐risk populations are lacking in the literature.ProcedureWe performed retrospective analysis of all oncology patients diagnosed at our center from 2014 to 2019, who underwent TRIO screening as part of an internal quality improvement project. Correlations of MRI‐confirmed TRIO with patient‐, disease‐, and treatment‐specific features were evaluated.ResultsWe show that a tiered screening algorithm for TRIO, when followed as intended, led to the identification of the highest proportion of patients with TRIO. We confirm that cardiac TRIO is quite rare in the oncology patient population. However, accepted surrogate markers including red blood cell transfused volume and ferritin only modestly correlated with TRIO in our patient cohort. Instead, we found that older age, leukemia diagnosis, anthracycline exposure, and receipt of stem cell transplant were most strongly associated with risk for TRIO.ConclusionsWe describe associations between TRIO and patient, disease, and treatment characteristics in a multivariate risk model that could lead to an improved risk stratification of off‐therapy patients, and which should be validated in a prospective manner.
Influence of out‐of‐autoclave and autoclave manufacturing processes on mechanical properties of glass fiber‐reinforced epoxy composite
Authors: Dewangan Bhishm , Chakladar N. D. 
Published: August 2024

AbstractIn this study, an optimum process parameter space is proposed by comparing autoclave, oven curing and vacuum infusion process of manufacturing of GFRP composites. The process parameters, such as the degassing time of resin‐hardener mix, single or double vacuum bagging (DVB), fiber volume fraction and condition of the vacuum pump (VP) were considered. The novelty of the study shows that a VP Off and 5 min degassing condition exhibited 27%, 18% and 27% increase in tensile modulus, tensile strength and interlaminar shear strength as compared to the other methods. The normalized tensile strength, on the other hand, was comparable with DVB, oven and autoclave curing. A magnitude of 1.5 MPa of residual stress was measured with the help of x‐ray diffraction (XRD). This was verified by a Raman Spectroscopy, which showed a residual strain of 0.2% at a spectral peak of 1186 cm−1. The proposed methodology would assist the industries in choosing the right combination of process parameters required for a targeted tensile and interlaminar performance.Highlights
Effect of out‐of‐autoclave and autoclave processes on the performance of GFRP was studied.
Degassing time, vacuum bagging and Vacuum pump conditions were investigated.
Vacuum pump Off and 5 min degassing time were found to be optimal.
Tensile and Interlaminar shear strength were improved by 18% and 27% at optimal condition.
Study on the process of hot gas‐assisted GF/PA5X thermoplastic composites automated tape placement
Authors: Liu Hao , Li Yong , Huan Da‐Jun , Zhu Kang , Guo Da 
Published: August 2024

AbstractThe thermoplastic composites which in the automated tape placement (ATP) process are directly consolidated and formed in situ. The interlaminar bonding quality of the product is susceptible to the ATP process. Glass fiber‐reinforced bio‐based polyamides PA5X (GF/PA5X) tapes are used to prepare samples. The effect of process parameters on the interlaminar bonding quality is explored by peel test based on the principle of the response surface. A quadratic response surface model of hot gas temperature, placement speed, and roller force on the peel strength is established, and experiments are conducted to verify the accuracy of the model. The effect of process parameters and their coupling effect on the peel strength is obtained. The interlaminar bonding quality of the samples manufactured by ATP and compression molding are comparatively analyzed through peel and short beam shear tests. The results show that the best combination of process parameters obtained is: the hot gas temperature of 619°C, placement speed of 0.540 m/min, roller force of 684 N, and predicted peel strength of 9.89 N/10 mm. The peel and short beam shear strength of the samples manufactured by ATP is 9.96 N/10 mm and 34.2 MPa, reaching 66.0% and 60.0% of the samples manufactured by compression molding respectively.Highlights
GF/PA5X thermoplastic composite tapes are used to prepare ATP samples.
The effect of process parameters on the interlaminar bonding quality is explored.
The micromorphology of the ATP samples is characterized.
The ATP and compression molding samples are comparatively analyzed.