bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fully Automated MRI-based Analysis of the Locus Coeruleus in Aging and Alzheimer’s Disease Dementia using ELSI-Net
Authors: Dünnwald Max , Krohn Friedrich , Sciarra Alessandro , Sarkar Mousumi , Schneider Anja , Fliessbach Klaus , Kimmich Okka , Jessen Frank , Rostamzadeh Ayda , Glanz Wenzel , Incesoy Enise I. , Teipel Stefan , Kilimann Ingo , Goerss Doreen , Spottke Annika , Brustkern Johanna , Heneka Michael T. , Brosseron Frederic , Lüsebrink Falk , Hämmerer Dorothea , Düzel Emrah , Tönnies Klaus , Oeltze-Jafra Steffen , Betts Matthew J. 
Published: July 2024

AbstractINTRODUCTIONThe Locus Coeruleus (LC) is linked to the development and pathophysiology of neurodegenerative diseases such as Alzheimer’s Disease (AD). Magnetic Resonance Imaging based LC features have shown potential to assess LC integrity in vivo.METHODSWe present a Deep Learning based LC segmentation and feature extraction method: ELSI-Net and apply it to healthy aging and AD dementia datasets. Agreement to expert raters and previously published LC atlases were assessed. We aimed to reproduce previously reported differences in LC integrity in aging and AD dementia and correlate extracted features to cerebrospinal fluid (CSF) biomarkers of AD pathology.RESULTSELSI-Net demonstrated high agreement to expert raters and published atlases. Previously reported group differences in LC integrity were detected and correlations to CSF biomarkers were found.DISCUSSIONAlthough we found excellent performance, further evaluations on more diverse datasets from clinical cohorts are required for a conclusive assessment of ELSI-Nets general applicability.Highlightsthorough evaluation of a fully automatic LC segmentation method termed ELSI-Net in aging and AD dementiaELSI-Net outperforms previous work and shows high agreement with manual ratings and previously published LC atlasesELSI-Net replicates previously shown LC group differences in aging and ADELSI-Net’s LC volume correlates with CSF biomarkers of AD pathologyRESEARCH IN CONTEXTSystematic Review:The authors reviewed the literature using traditional sources (e.g. Pubmed, Google Scholar). Although there are several publications introducing semi-automatic methods for LC segmentation, the application of Deep Learning methods is underexplored. To the best of our knowledge, this is the first paper using a Deep Learning based approach for automated LC segmentation in AD dementia.Interpretation:Our work introduces and evaluates an improved automatic, Deep Learning based LC segmentation and analysis approach. The results suggest a very high potential for practical applicability, e.g. in large-scale clinical studies for neurodegenerative diseases.Future Directions:ELSI-Net can be used to assess LC integrity on large- or small-scale studies in Alzheimer’s Disease dementia. To ensure robust performance, ELSI-Net should be further evaluated in larger, more diverse datasets comprising varying LC MRI protocols and clinical populations.
Evidence of centromeric histone 3 chaperone involved in DNA damage repair pathway
Authors: Agarwal Prakhar , Ghosh Santanu Kumar 
Published: July 2024

AbstractThe centromeric protein-A (CENP-A) is an evolutionary conserved histone H3 variant that marks the identity of the centromeres. Several mechanisms regulate the centromeric deposition of CENP-A as its mislocalization causes erroneous chromosome segregation, leading to aneuploidy-based diseases, including cancers. The most crucial deposition factor is a CENP-A specific chaperone, HJURP (Scm3 in budding yeast), which specifically binds to CENP-A. However, the discovery of HJURP as a DDR (DNA damage repair) protein and evidence of its binding to Holliday junctions in vitro indicate a CENP-A-deposition-independent role of these chaperones. In this study, using budding yeast, we demonstrate that Scm3 is crucial for the DDR pathway asscm3cells are sensitive to DNA damage. We further observe that thescm3mutant interacts with therad52DDR mutant and is compromised in activating DDR-mediated arrest. We demonstrate that Scm3 associates with the DNA damage sites and undergoes posttranslational modifications upon DNA damage. Overall, from this report and earlier studies on HJURP, we conclude that DDR functions of CENP-A chaperones are conserved across eukaryotes. Thus, the revelation that these chaperones confer genome stability in more than one pathway has clinical significance.
Limiting the impact of protein leakage in single-cell proteomics
Authors: Leduc Andrew , Xu Yanxin , Shipkovenska Gergana , Dou Zhixun , Slavov Nikolai 
Published: July 2024

AbstractLimiting artifacts during sample preparation can significantly increase data quality in single-cell proteomics experiments. Towards this goal, we characterize the impact of protein leakage by analyzing thousands of primary single cells that were prepared either fresh immediately after dissociation or cryopreserved and prepared at a later date. We directly identify permeabilized cells and use the data to define a signature for protein leakage. We use this signature to build a classifier for identifying damaged cells that performs accurately across cell types and species.
The effect of regional factors on energy poverty
Authors: Jové-LLopis Elisenda , Trujillo-Baute Elisa 
Published: July 2024

Purpose
Within the framework of EU policies and measures to develop a just and fair green energy transition model. This paper aims to offer valuable insights into a paramount concern not so well debated in the literature, i.e. the spatial variation of energy poverty.

Design/methodology/approach
This empirical analysis investigates the regional variation of energy poverty we draw on a sample of more than 300,000 Spanish households, extracted from the Spanish Household Budget Survey (HBS) for the period 2006–2022. To characterize the probability of a household finding itself in a situation of energy poverty the authors use a discrete choice univariate probit model.

Findings
The results confirm that energy poverty is a phenomenon that is asymmetrically distributed across Spain, and mainly occurs in un-densely populated regions. In addition, the findings demonstrate that the incidence of energy poverty drivers is highly heterogeneous across regions.

Research limitations/implications
The paper ends with some recommendations for policymakers suggesting that countries need to design an energy poverty policy for the households that jointly pursue both a correct identification of vulnerable groups and a match with the type of measure to the characteristics of each region.

Originality/value
This study enhances previous research by considering the case of areas at a lower level of aggregation (i.e. on the NUTS two regions in Spain called autonomous communities) and offers the opportunity to tailor policies to those regions most in need. Furthermore, to provide a more realistic picture of the complex phenomenon of energy poverty, the authors use the information for the period 2006–2022 differentiating by economic micro-cycle. This timespan allows the authors to understand the dynamics of energy poverty in periods of economic crisis, including the effects of the 2008 crisis and the present global energy crisis.
CC-index is a scite-based enhancement of citation metrics
Authors: Gonmei Thuanthailiu , Ravikumar S. , Gayang Fullstar Lamin 
Published: July 2024

Purpose
The purpose of this study is to gain insight into how citations are distributed and concentrated in the introduction, methods, discussion, results and other sections of journal articles to determine which section has received the most citations and whether the citation concentration score affects how articles rank.

Design/methodology/approach
The present study uses scite.ai and the Dimensions database to emphasize the significance of including multiple in-text citations in evaluating the impact and quality of journal publications. The study has two approaches: paper-based and author-based.

Findings
The study provides empirical insights into how variations in ranking are observed when citation concentration is considered in the evaluation process. It also suggests that in-text citations be used as an evaluation criterion or aspect for assessing the impact and quality of journals, publications and authors.

Originality/value
This study underscores the importance of considering citation concentration when evaluating journal articles. To assess highly cited articles, it suggests using the CC-index method, which is based on scite.ai.
Examining the influence of gender equality in HRMP on job performance: the mediating role of job satisfaction
Authors: Taamneh Mohammad M. , Al-Okaily Manaf , Barhem Belal , Taamneh Abdallah M. , Alomari Ziyad Saleh 
Published: July 2024

Purpose
The purpose of this study is to investigate the impact of gender equality in human resource management practices (HRMP) on job performance in educational hospitals in Jordan. This paper also examines the role of job satisfaction as a mediator between gender equality in HRMP and job performance.

Design/methodology/approach
A quantitative research approach with an online questionnaire was used to collect data from 231 participants at educational hospitals.

Findings
The findings showed that gender equality in HRMP was positively associated with job performance. In addition, the findings found a significant positive effect of gender equality in HRM on job satisfaction. Finally, the findings indicated that job satisfaction mediates the relationship between gender equality in HRMP and job performance.

Originality/value
This study provided theoretical and practical insights on the issue of discrimination against women, representing a model of developing countries, especially in the Middle East.
Who are the key figures in Grand Tours cycling events publications? A systematic review of main themes
Authors: Gholampour Behzad , Noruzi Alireza , Elahi Alireza , Barranco Gil David , Gholampour Sajad 
Published: July 2024

Purpose
The purpose of this study is to draw a scientific map of the Grand Tours cycling as part of the growing research field in this field at the global level. This study also identifies the components of scientific production in this field along with their collaboration patterns.

Design/methodology/approach
With the aim of achieving a comprehensive and deep understanding of the studies related to the Grand Tour, this research aims to address the existing gaps and provide a comprehensive summary of these scholarly works. To achieve this goal, the authors used a systematic and scientometric combination method, analyzing studies from the past half century (1970–2022).

Findings
The research findings reveal that scientific studies related to cycling events exhibit a geographical concentration within the continent of Europe, surpassing other continents. Notably, Spain, the USA, the UK and Italy emerge as pioneers in this field of inquiry. The main themes identified in these studies encompass cycling, the Tour de France, performance, professional roa cycling, heart rate, endurance, doping and power output.

Practical implications
This research, along with other systematic studies, contributes to the existing literature in this field by providing both quantitative and qualitative data. Additionally, the study serves as a foundation for identifying active and influential countries, institutions and authors in this domain. Such insights are highly effective in establishing scientific focal points in this field.

Originality/value
This study, in conjunction with the introduction of key figures in mega cycling event research, sheds light on the thematic areas explored within these studies. Notably, it is the sole study that has illuminated hidden facets of this field using scientometric and systematic methods.
Effect of curvature on bubble dynamics and associated heat transfer characteristics for nucleate pool boiling from a hydrophilic curved surface
Authors: Sharma Abhishek Kumar , Tiwari Shaligram 
Published: July 2024

Purpose
This paper aims to carry out numerical study on growth of a single bubble from a curved hydrophilic surface, in nucleate pool boiling (NPB). The boiling performance associated with NPB on a curved surface has been analyzed in contrast to a plane surface.

Design/methodology/approach
Commercial software ANSYS Fluent 2021 R1 has been used with its built-in feature of interface tracking based on volume of fluid method. For water as the working fluid, the effect of microlayer evaporation underneath the bubble base has been included with the help of user-defined function. The phase change behavior at the interface of vapor bubble has been modeled by using “saturated-interface-volume” phase change model.

Findings
An interesting outcome of the present study is that the bubble departure gets delayed with increase in curvature of the heating surface. Wall heat flux is found to be higher for a curved surface as compared to a plane surface. Effect of wettability on the time for bubble growth is relatively more for the curved surface as compared to that for a plane surface.

Originality/value
Effect of surface curvature has been investigated on bubble dynamics and also on temporal variation of heat flux. In addition, the impact of surface wettability along with the surface curvature has also been analyzed on bubble morphology and spatial variation of heat flux. Furthermore, the influence of wall superheat on the bubble growth and also the wall heat flux has been studied for fixed angle of contact and varying curvature.
Velocity slip and temperature jump effects on entropy generation of MHD second-grade hybrid nanofluid in Jeffery-Hamel flow
Authors: Kezzar Mohamed , Talbi Nabil , Dinarvand Saeed , Das Sanatan , Sari Mohamed Rafik , Nasr Samia , Akhlaghi Mozaffar Ali 
Published: July 2024

Purpose
This paper aims to model and analyze Jeffery Hamel’s channel flow with the magnetohydrodynamics second-grade hybrid nanofluid. Considering the importance of studying the velocity slip and temperature jump in the boundary conditions of the flow, which leads to results close to reality, this paper intends to analyze the mentioned topic in the convergent and divergent channels that have significant applications.

Design/methodology/approach
The examination is conducted on a EG-H_2 O <30%–70%> base fluid that contains hybrid nanoparticles (i.e. SWCNT-MWCNT). To ensure comprehensive results, this study also considers the effects of thermal radiation, thermal sink/source, rotating convergent-divergent channels and magnetic fields. Initially, the governing equations are formulated in cylindrical coordinates and then simplified to ordinary differential equations through appropriate transformations. These equations are solved using the Explicit Runge–Kutta numerical method, and the results are compared with previous studies for validation.

Findings
After the validation, the effect of the governing parameters on the temperature and velocity of the second-grade hybrid nanofluid has been investigated by means of various and comprehensive contours. In the following, the issue of entropy generation and its related graphical results for this problem is presented. The mentioned contours and graphs accurately display the influence of problem parameters, including velocity slip and temperature jump. Besides, when thermal radiation is introduced (Rd = +0.1 and Rd = +0.2), entropy generation in convergent-divergent channels decreases by 7% and 14%, respectively, compared to conditions without thermal radiation (Rd = 0). Conversely, increasing the thermal sink/source from 0 to 4 leads to an 8% increase in entropy generation at Q = 2 and a 17% increase at Q = 4 in both types of channels. The details of the analysis of contours and the entropy generation results are fully mentioned in the body of the paper.

Originality/value
There are many studies on convergent and divergent channels, but this study comprehensively investigates the effects of velocity slip and temperature jump and certainly, this geometry with the specifications presented in this paper has not been explored before. Among the other distinctive features of this paper compared to previous works, the authors can mention the presentation of velocity and temperature results in the form of contours, which makes the physical analysis of the problem simpler.
A systematic review of the applicability of nature-based solutions for resilient urban residences in Southern Nigeria
Authors: Ayo-Odifiri Solomon Oisasoje 
Published: July 2024

Purpose
The adoption of nature-based solutions (NBS) for resilient cities has been receiving concern because of global threats of climate variation and a bid to achieve the Sustainable Development Goals 2030. NBS promotes a healthy environment and discourages land loss. NBS applications have been researched, especially in developing nations; however, there is a lack of evidence on their roles, impediments and drivers in southern Nigerian cities. Therefore, this study aims to systematically review the applicability of NBS for resilient urban residences (RUR) in southern Nigeria. Also, it proposes strategies for addressing environmental issues via a framework that will support future studies.

Design/methodology/approach
Southern Nigeria's riparian settlements are vulnerable to climate variability's devastating effects. A systematic review of literature on NBS for RUR resilience was conducted, sourcing 29 papers included in the study from 2004 to 2023 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses from Google Scholar, Scopus and Web of Science databases in November 2023.

Findings
The review identified three themes: NBS's role in fostering urban resilience, impediments to its application and drivers for resilient RUR, with five roles, eight impediments and eight drivers identified in the literature.

Research limitations/implications
This study explores literature on environmental drivers for practitioners promoting NBS, suggesting a qualitative research approach for advanced studies. However, the systematic review-based recommendations maintain the robustness of the NBS application for RUR in southern Nigeria, despite the need for advanced studies.

Practical implications
This study outlines the five roles, eight impediments and eight drivers for promoting the application of NBS in southern Nigeria. This study noted that NBS can improve urban residential precincts, maintain residents' quality of life, purify air, regulate temperature and reduce glare, urban heat and land loss. The findings can be used by environmental and construction practitioners, clients, academics and policymakers to promote NBS applications in Nigeria. Adapting NBS should be a basic consideration in residential property planning and design for building plan approval.

Originality/value
To the best of the authors’ knowledge, this systematic review analysis is the first to explore NBS application in Southern Nigeria RUR, offering flexible strategies to advance NBS in the Nigerian locale.
Examining the existence of twin deficits in Bolivia
Authors: Saavedra-Caballero Fabiola , Villca Alfredo 
Published: July 2024

PurposeWe examine the twin deficits and the direction of its movement for the case of Bolivia, a natural resource-dependent country, using the database of (Kehoe et al., 2019) from 1960 to 2019.Design/methodology/approachWe combine a structural vector autoregression (SVAR) model with a dynamic stochastic general equilibrium (DSGE) model to understand the transmission mechanisms.FindingsOur results suggest the existence of twin deficits in Bolivia; however, causality in the Mundell-Fleming sense does not hold. While fiscal policy shocks explain current account deficits, current account shocks have a stronger effect over fiscal deficit. In fact, only 23% of the variance of current account forecast errors is explained by fiscal policy shocks; in contrast, 45% of the variance of the fiscal deficit is explained by current account shocks.Research limitations/implicationsThe study is for a specific case, which is a limitation; however, other country samples can be included.Practical implicationsBased on the results of the work, policies can be recommended and designed to cushion the effects of external shocks.Originality/valueAccording to the literature available for the Bolivian case, our work constitutes a significant contribution and, therefore, is original for this specific case.
Unlocking green potential: a mediation-moderation analysis of bank policies-related practices and green financing sustainability in Pakistan
Authors: Iqbal Zahid , Akram Muhammad , Rao Zia Ur Rehman 
Published: July 2024

Purpose
This study aims to investigate the relationship between bank policy-related practices and green financing sustainability in Pakistan. The study uses a mediating-moderation analysis to examine how the influence of bank policies on green financing sustainability is mediated by green banking activities and moderated by the employees’ green value and green knowledge sharing.

Design/methodology/approach
In this study, a structural questionnaire was used to gather data from Pakistani bank personnel through stratified sampling. A two-stage structural equation modelling approach was used in this investigation. The measuring scale’s validity and reliability are assessed using the measure model. A structural model was used to ascertain the connection between the underpinning constructs.

Findings
This study found a positive significant effect on bank employed related practices on green banking activities, besides the mediate role of green banking activities between the bank policies-related practices and green financing. In addition, this study also found the moderating role of employees’ green value and green knowledge sharing on the relationship of bank policies-related practices and green banking activities as well as green banking activities and green financing, respectively.

Originality/value
As environmental sustainability becomes more and more important on a worldwide scale; the study looks into the ways that financial institutions may become more environmentally conscious and help create a more sustainable future. To shed light on the ways in which financial institutions can be crucial in advancing green sustainability in an emerging economy such as Pakistan, this study used sophisticated statistical tools.