bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of demand management in achieving supply chain agility
Authors: M. Gligor David 
Published: October 2014

Purpose
– The purpose of this paper is to explore the role of demand management in achieving supply chain agility (SCA) through a multi-disciplinary review of the relevant research. The systematic literature review provides the basis for formulating a conceptual framework of the relationship.

Design/methodology/approach
– A systematic, comprehensive review of the literature on manufacturing, marketing organizational and SCA from 1991 through 2013 was conducted. The literature on demand management is also examined to identify the various elements that contribute to SCA.

Findings
– Most agility frameworks take a supply-side perspective and assume that demand is known. Those that do acknowledge the role of demand fall short of offering a holistic framework that acknowledges the role of both. This paper suggests that it is simply not enough to have flexible manufacturing, distribution and procurement systems to achieve SCA. Flexibility in managing demand is also needed. Furthermore, it is the premise of this paper that demand and supply integration (DSI) inside the firm is critical to achieving SCA.

Research limitations/implications
– This research is a systematic, integrative review of the existing literature on the concept of agility. As such, the next phase of research needed for theory building will be the operationalization of constructs and testing of the hypothesized relationships proposed by the conceptual framework.

Practical implications
– The paper has several managerial implications as well. It illustrates how firms can create and sustain competitive advantages in turbulent environments. Managers can use the framework developed here to assess what structures and decision-making processes they can use to increase the firm’s SCA. Practitioners can use this model as a checklist to identify candidate areas for improving agility. The section illustrating the use of knowledge management to increase DSI should be of particular interest to managers, considering that a great deal of firms experience a disconnect between demand creation and supply fulfillment.

Originality/value
– Through a systematic, comprehensive review of multi-disciplinary literature, the paper explores the role of demand management in achieving SCA.
Grading criteria for disease severity by pemphigus disease area index
Authors: Shimizu Tomoko , Takebayashi Toru , Sato Yuji , Niizeki Hironori , Aoyama Yumi , Kitajima Yasuo , Iwatsuki Keiji , Hashimoto Takashi , Yamagami Jun , Werth Victoria P. , Amagai Masayuki , Tanikawa Akiko 
Published: October 2014

AbstractPemphigus is a group of autoimmune blistering diseases that affect the skin and mucous membranes. A reliable and accurate disease severity tool to assess pemphigus severity is crucial for managing pemphigus and for clinical trials. The purpose of this study was to compare the pemphigus disease area index activity score (PDAI), the Japanese pemphigus disease severity score (JPDSS) and the physician's subjective impression, and also to find appropriate severity grading cut‐offs for the PDAI. We also evaluated the correlation between PDAI activity score and the JPDSS. Thirty‐seven pemphigus patients and 110 assessments were analyzed in this study. The optimal points of pemphigus disease severity score in PDAI were: mild (0–8), moderate (9–24) and severe (≥25). In mild or moderate cases, the JPDSS was well correlated with the PDAI, but in severe cases the JPDSS reached a plateau at a PDAI score of approximately 30. The PDAI evaluates disease severity more accurately than the JPDSS, particularly in severe cases. The PDAI is not only a useful tool to measure the extent of cutaneous lesions, but also an excellent scoring system for evaluating pemphigus disease severity.
Overview of clinically approved oral antidiabetic agents for the treatment of type 2 diabetes mellitus
Authors: He Zhi‐Xu , Zhou Zhi‐Wei , Yang Yinxue , Yang Tianxin , Pan Si‐Yuan , Qiu Jia‐Xuan , Zhou Shu‐Feng 
Published: October 2014

SummaryType 2 diabetes mellitus (T2DM) is caused by insulin resistance and characterized by progressive pancreatic β‐cell dysfunction. This articles reviews the application and limitations of currently approved oral drugs for the treatment of T2DM. Data were retrieved from the literature and well‐recognized drug‐related databases. Although lifestyle modifications and metformin are the cornerstones of the initial management of T2DM, there is an increasing array of second‐ and third‐line pharmacological agents, including sulphonylureas, insulin, thiazolidinediones and glitazones, α‐glucosidase inhibitors, glucagon‐like peptide‐1 agonists, dipeptidyl peptidase 4 inhibitors and the amylin receptor agonist pramlintide. Current T2DM treatment focuses on reducing blood glucose levels via different mechanisms, including nuclear hormone receptors, nucleic acid binding proteins, transcription factors, voltage‐gated K+ channels, glucosidase, G‐protein‐coupled receptors and non‐receptor serine/threonine protein kinase. Extensive efforts are needed to address the pathogenesis of T2DM, which may facilitate the development of new therapies and the identification of new therapeutic targets to overcome the shortcomings of currently available drugs for T2DM and to achieve therapeutic goals.
Aortic dissection presenting an acute onset of neuroradicular syndrome complicated by coeliac and superior mesenteric artery embolism
Authors: Zeng Lixiong , Yuan Hong , Jiang Weihong , Yang Kan , Zhang Zhihui 
Published: October 2014

AbstractAortic dissection is a catastrophic medical emergency with complex and changeable clinical presentations. We report a case of aortic dissection complicated by coeliac and superior mesenteric artery embolism, which is hardly been reported till date.
Design, Synthesis, and Biological Evaluation of Novel 4‐Aminopiperidinyl‐linked 3,5‐Disubstituted‐1,2,6‐thiadiazine‐1,1‐dione Derivatives as HIV‐1 NNRTIs
Authors: Liu Tao , Huang Boshi , Tian Ye , Liang Xin , Liu Hong , Liu Huiqing , Zhan Peng , De Clercq Erik , Pannecouque Christophe , Liu Xinyong 
Published: October 2014

Based on the hybridization of the privileged fragments in DABO and DAPY‐typed HIV‐1 NNRTIs, a novel series of 4‐aminopiperidinyl‐linked 3,5‐disubstituted‐1,2,6‐thiadiazine‐1,1‐dione derivatives were designed, synthesized, and evaluated for their in vitro anti‐HIV activities in MT‐4 cells. Most of the target compounds showed weak inhibitory activity against WT HIV‐1. In order to confirm the mode of action of the target compounds, representative compounds Ba8 and Bb8 were selected to perform the HIV‐1 RT inhibitory assay. In this assay, Ba8 and Bb8 displayed good activity with IC50 values of 3.15 and 1.52 μm, respectively. Additionally, preliminary structure–activity relationships (SARs) analysis and molecular docking studies of newly synthesized compounds are also discussed.
Detection of aquaporin‐4 antibody status of Thai patients with neuromyelitis optica spectrum disorders using a recombinant Escherichia coli aquaporin‐4 enzyme‐linked immunosorbent assay
Authors: Kanjan Kulaya , Siritho Sasitorn , Apiwattanakul Metha , Prayoonwiwat Naraporn , Uawithya Panapat 
Published: October 2014

AbstractObjectivesNeuromyelitis optica (NMO) is a severe inflammatory demyelinating disease of the central nervous system. Detection of a highly specific autoantibody to aquaporin‐4 (AQP4) in the serum has been used as a diagnostic marker for NMO. The aim of the present study was to evaluate and validate the enzyme‐linked immunosorbent assay (ELISA) for detecting AQP4 antibody using recombinant AQP4 antigen expressed on Escherichia coli, and assessing its usefulness in diagnosis of NMO among Thai patients.MethodsSera of the 57 patients who attended the neurology service at Siriraj Hospital and were suspected to have central nervous system demyelinating diseases were tested, along with the sera of normal subjects. AQP4 with a green fluorescent tag was expressed on E. coli BL21 DE3 pLysS. Assessment of the AQP4 antibody was carried out using ELISA, and the obtained data were compared with pre‐ and post‐fixed cell‐based indirect immunofluorescence assay (CBA‐kit and Sendai method cell‐based assay), and tissue‐based indirect immunofluorescence assay.ResultsRecombinant AQP4 proteins were successfully expressed in the E. coli. Crude lysates of E. coli expressing full length AQP4 were used as antigens for the patients’ sera in the ELISA. The sensitivity and specificity of the ELISA were 96.7% and 92.3%, respectively, and they were highly correlated (kappa coefficient, 0.894) compared with the Sendai method cell‐based assay.ConclusionsThe detection of AQP4 antibodies with ELISA using recombinant E. coli AQP4 antigen provides highly sensitive and specific diagnoses for Thai spectrum disorders patients. This method should be used as an economically viable alternative routine screening test for patients whose clinical symptoms suggest NMO.
Gestational stress induces persistent depressive‐like behavior and structural modifications within the postpartum nucleus accumbens
Authors: Haim Achikam , Sherer Morgan , Leuner Benedetta 
Published: October 2014

AbstractPostpartum depression (PPD) is a common complication following childbirth experienced by one in every five new mothers. Pregnancy stress enhances vulnerability to PPD and has also been shown to increase depressive‐like behavior in postpartum rats. Thus, gestational stress may be an important translational risk factor that can be used to investigate the neurobiological mechanisms underlying PPD. Here we examined the effects of gestational stress on depressive‐like behavior during the early/mid and late postpartum periods and evaluated whether this was accompanied by altered structural plasticity in the nucleus accumbens (NAc), a brain region that has been linked to PPD. We show that early/mid (postpartum day 8) postpartum female rats exhibited more depressive‐like behavior in the forced swim test as compared with late postpartum females (postpartum day 22). However, 2 weeks of restraint stress during pregnancy increased depressive‐like behavior regardless of postpartum timepoint. In addition, dendritic length, branching and spine density on medium spiny neurons in the NAc shell were diminished in postpartum rats that experienced gestational stress although stress‐induced reductions in spine density were evident only in early/mid postpartum females. In the NAc core, structural plasticity was not affected by gestational stress but late postpartum females exhibited lower spine density and reduced dendritic length. Overall, these data not only demonstrate structural changes in the NAc across the postpartum period, they also show that postpartum depressive‐like behavior following exposure to gestational stress is associated with compromised structural plasticity in the NAc and thus may provide insight into the neural changes that could contribute to PPD.
Reinnervated nerves contribute to the secretion function and regeneration of denervated submandibular glands in rabbits
Authors: Zhang Si‐en , Su Yu‐xiong , Zheng Guang‐sen , Liang Yu‐jie , Liao Gui‐qing 
Published: November 2014

This study aimed to investigate the contribution of redistributed nerves in the secretory function and regeneration of a denervated submandibular gland (SMG). The postganglionic parasympathetic and sympathetic denervated SMGs of rabbits were wrapped in polyester or acellular dermal matrices to block nerve regeneration either partially or completely. Submandibular glands were removed 4, 8, 16, and 24 wk after the operation and examined histologically. Furthermore, the aquaporin‐5 (AQP5), muscarinic‐3 (M3), and β1‐adrenergic receptors were evaluated by immunofluorescence and western blot analysis. After denervation, salivary flow was decreased and acinar cells were atrophic, and the expression levels of the M3, β1‐adrenergic, and AQP5 receptors were decreased. However, both impaired secretion function and atrophic parenchyma were gradually ameliorated with the growing redistribution of parasympathetic and sympathetic nerves. Apoptosis was markedly inhibited and expression of the M3, β1‐adrenergic, and AQP5 receptors was increased after reinnervation. In contrast, SMGs without reinnervated nerves maintained hyposecretion and atrophic parenchyma. In conclusion, reinnervated nerves in a rabbit's denervated SMG played an important role in the secretion function and regeneration of SMGs via up‐regulation of the expression of neurotransmitter receptors and AQP5.
Does Measuring L2 Utterance Fluency Equal Measuring Overall L2 Proficiency? Evidence From Five Languages
Authors: Baker‐Smemoe Wendy , Dewey Dan P. , Bown Jennifer , Martinsen Rob A. 
Published: November 2014

AbstractThe current study examined the relationship between overall second language (L2) proficiency and utterance fluency measures for several L2s in order to determine whether utterance measures can be used to predict L2 proficiency. The study measured the speech rate, number of hesitations, number and length of pauses, number and length of runs, and number of false starts using excerpts from 126 ACTFL Oral Proficiency Interviews (OPIs) spoken by 86 participants. Forty of the participants provided pre‐ and post‐OPI speech samples, which also allowed examination of changes over time. All 86 participants were native English speakers who spoke L2 French, German, Japanese, Arabic, or Russian. They ranged in proficiency from Novice Mid to Superior. Results suggested that some L2 utterance fluency measures correlated significantly with overall L2 proficiency for all L2s, but data also revealed some differences across L2s. These differences hinged partly on the L2's relative difficulty for native English speakers. Results suggested that it might be feasible to use specific fluency measures to estimate proficiency, in particular at higher levels, but that fine‐grained sublevel estimates would not be recommended, in particular at the Novice and Intermediate levels.
Dynamic Processes of Speech Development by Seven Adult Learners of Japanese in a Domestic Immersion Context
Authors: Fukuda Makiko 
Published: October 2014

AbstractThe present study revealed the dynamic process of speech development in a domestic immersion program by seven adult beginning learners of Japanese. The speech data were analyzed with fluency, accuracy, and complexity measurements at group, interindividual, and intraindividual levels. The results revealed the complex nature of language development among and within individuals. The reasons for such dynamicity and pedagogical implications are discussed.
World Language Teacher Candidate Performance on edTPA: An Exploratory Study
Authors: Hildebrandt Susan A. , Swanson Pete 
Published: November 2014

AbstractFederal and state legislation continues to promote teacher accountability in the United States. The new edTPA, a subject‐specific teacher performance assessment, is purported to measure beginning teacher readiness and is being pilot tested and implemented for licensure and certification decisions across the country. In this exploratory quantitative study, the researchers examined edTPA scores of 21 world language teacher candidates from two teacher preparation programs and compared those results to the cut scores for the states of Washington and New York. Results indicated that participants performed best in the planning section and were most challenged by the assessment section. This research has implications for teacher certification candidates, world language teacher preparation programs, policy makers, and other stakeholders.
Disparate effects of global‐change drivers on mountain conifer forests: warming‐induced growth enhancement in young trees vs. CO2 fertilization in old trees from wet sites
Authors: Camarero J. Julio , Gazol Antonio , Galván Juan Diego , Sangüesa‐Barreda Gabriel , Gutiérrez Emilia 
Published: November 2014

AbstractTheory predicts that the postindustrial rise in the concentration of CO2 in the atmosphere (ca) should enhance tree growth either through a direct fertilization effect or indirectly by improving water use efficiency in dry areas. However, this hypothesis has received little support in cold‐limited and subalpine forests where positive growth responses to either rising ca or warmer temperatures are still under debate. In this study, we address this issue by analyzing an extensive dendrochronological network of high‐elevation Pinus uncinata forests in Spain (28 sites, 544 trees) encompassing the whole biogeographical extent of the species. We determine if the basal area increment (BAI) trends are linked to climate warming and increased ca by focusing on region‐ and age‐dependent responses. The largest improvement in BAI over the past six centuries occurred during the last 150 years affecting young trees and being driven by recent warming. Indeed, most studied regions and age classes presented BAI patterns mainly controlled by temperature trends, while growing‐season precipitation was only relevant in the driest sites. Growth enhancement was linked to rising ca in mature (151–300 year‐old trees) and old‐mature trees (301–450 year‐old trees) from the wettest sites only. This finding implies that any potential fertilization effect of elevated ca on forest growth is contingent on tree features that vary with ontogeny and it depends on site conditions (for instance water availability). Furthermore, we found widespread growth decline in drought‐prone sites probably indicating that the rise in ca did not compensate for the reduction in water availability. Thus, warming‐triggered drought stress may become a more important direct driver of growth than rising ca in similar subalpine forests. We argue that broad approaches in biogeographical and temporal terms are required to adequately evaluate any effect of rising ca on forest growth.
Rebuilding the ship at sea: super‐diversity, person and conduct in eastern Oslo
Authors: ERIKSEN THOMAS HYLLAND 
Published: October 2014

AbstractResearchers on transnationalism and migration in contemporary Europe often insufficiently communicate or even neglect the major shift between the first and second generation. Using empirical material from eastern Oslo, I argue that the dominant conceptualization of the self, of personhood, has shifted from a chiefly sociocentric to a chiefly egocentric form of selfhood, with important consequences for the process of integration into Norwegian society. At the same time, this change in personhood, a result of wide‐ranging participation in the institutions of majority society, does not per se lead to a weakening of religious or ethnic identity, although they are now reflexively chosen and not adhered to as a duty or social obligation. This process of individualization creates a situation of multiple, complex adaptations rather than one of stable, coherent diasporic populations, one where even conservative traditions have to be chosen actively because they no longer recommend themselves. Members of the second generation are compelled to balance the demands of two social ontologies, one emphasizing security and group cohesion, the other favouring freedom and individuality.
Weak impact of tourism activities on biodiversity in a subterranean hotspot of endemism and its implications for the conservation of cave fauna
Authors: Faille Arnaud , Bourdeau Charles , Deharveng Louis 
Published: October 2014

Abstract

La Verna chamber (France, western Pyrenees), the largest underground chamber in France, hosts 18 species of endemic hypogean invertebrates, all highly modified (troglobitic). It was recently opened for tourism activities.

To estimate the risks incurred by its fauna in this new environmental context, we conducted a 3‐year survey of the terrestrial fauna of the cave, focusing on the four steno‐endemic species of beetles present.

We established five sampling spots in the chamber that were monitored every 3 to 4 months during 3 years.

Our results did not detect any negative impact of the tourism activity on cave biodiversity. Neither the number of observed specimens nor the species richness decreased in the control spots.

The huge size of the chamber is assumed to prevent significant microclimatic changes and the presence of very large boulders and cracks is assumed to offer plenty of suitable spaces, which allow invertebrates to escape local disturbance and illumination.

In spite of the high vulnerability of cave organisms, disturbance of cave habitats does not necessarily result in biodiversity decrease, if the cave disturbance is limited in duration, intensity, and spatial coverage with respect to the cave size.
An integrative review of fathers' experiences during pregnancy and childbirth
Authors: Poh H.L. , Koh S.S.L. , He H.‐G. 
Published: October 2014

BackgroundWhile fathers are increasingly expected to participate during their partners' pregnancies and childbirth and many studies have reported their experiences during these periods, no review studies have examined fathers' experiences and needs during pregnancy and childbirth together.AimTo provide an overview of evidence on fathers' experiences and needs during their partners' pregnancies and childbirth to identify any gaps in the existing literature and practice.MethodsAn integrative literature review was performed to analyse and synthesize fathers' experiences and/or needs during pregnancy and/or childbirth based on articles published in CINAHL, PubMed, Scopus, PsycINFO and Web of Science databases between the years 2002 and 2012. Only articles found in the National University of Singapore's online library collection were retrieved.ResultsAltogether, 25 studies (six quantitative and 19 qualitative studies) that reported fathers' experiences during pregnancy (n = 8), childbirth (n = 13) or during both periods (n = 4) were reviewed. Fathers experienced mixed feelings both during pregnancy and childbirth. They required support from their partners and healthcare professionals and wanted to be informed, involved and respected. However, more studies are needed to explore this phenomenon in different cultural contexts or care models.ConclusionThis review provides evidence for healthcare professionals to pay more attention to fathers when delivering perinatal care. Sociocultural‐sensitive interventions should be developed to facilitate a smoother transition to fatherhood.Implications for nursing and health policyFather‐specific information should be given to prepare fathers for pregnancy and childbirth. Healthcare professionals and policymakers should take fathers' feelings and concerns into consideration and provide family‐centred care to the couple during the antenatal and intrapartum periods.