bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave‐Assisted Facile and Rapid Friedel—Crafts Benzoylation of Arenes Catalyzed by Bismuth Trifluoromethanesulfonate.
Authors: Tran Phuong Hoang , Hansen Poul Erik , Pham Thuy Thanh , Huynh Vy Thanh , Huynh Vy Hieu , Tran Thao Du Thi , Huynh Thanh Van , Le Thach Ngoc 
Published: February 2015

AbstractThe title reaction proceeds with a variety of electron‐rich as well as electron‐poor aromatic compounds to yield the corresponding benzoylated products in good yield.
ChemInform Abstract: An Efficient and Practical Synthesis of BINAM Derivatives by Diastereoselective [3,3]‐Rearrangement.
Authors: Li Bing , Zhang Shengyong , Chen Weiping 
Published: February 2015

AbstractAcid‐catalyzed [3,3]‐sigmatropic rearrangement of readily accessible N‐(‐)‐methoxycarbonyl‐dinaphthylhydrazines (IV) affords two easily separable diastereomers [(Rax) and (Sax)] of 2′‐amino‐1,1′‐binaphthylcarbamates (V), which can be easily hydrolyzed into enantiomerically pure 1,1′‐binaphthyl‐2,2′‐diamines.
ChemInform Abstract: Microwave‐Promoted Efficient Synthesis of Spiroindenotetrahydropyridine Derivatives via a Catalyst‐ and Solvent‐Free Pseudo One‐Pot Five‐Component Tandem Knoevenagel/Aza‐Diels—Alder Reaction.
Authors: Bhuyan Debajyoti , Sarmah Manas M. , Dommaraju Yuvaraj , Prajapati Dipak 
Published: February 2015

AbstractSpiroindenotetrahydropyridine derivatives are synthesized from 1,3‐indanedione (I), aromatic aldehydes (II), and ammonium acetate.
ChemInform Abstract: Catalytic Enantioselective Carboannulation with Allylsilanes.
Authors: Ball‐Jones Nicolas R. , Badillo Joseph J. , Tran Ngon T. , Franz Annaliese K. 
Published: February 2015

AbstractThe first catalytic asymmetric [3 + 2] annulation of 3‐methylene substituted oxindoles with allylsilanes is developed to give spirocyclopentane derivatives in high diastereo‐ and enantioselectivity.
ChemInform Abstract: Iron‐Promoted Domino Annulation of α‐Enolic Dithioesters with Ninhydrin under Solvent‐Free Conditions: Chemoselective Direct Access to Indeno[1,2‐b]thiophenes.
Authors: Koley Suvajit , Chowdhury Sushobhan , Chanda Tanmoy , Ramulu B. Janaki , Nandi Ganesh Chandra , Singh Maya Shankar 
Published: February 2015

AbstractThe title reaction of ninhydrin with dithioesters gives condensed thiophenes in high yields.
ChemInform Abstract: Stereoselective Synthesis of Indolines via Organocatalytic Thioester Enolate Addition Reactions.
Authors: Kolarovic Andrej , Kaeslin Alexander , Wennemers Helma 
Published: February 2015

AbstractThe synthesis of indolines (VIII) involves enantioselective addition of monothiomalonate (II) to nitrostyrenes and intramolecular Buchwald—Hartwig coupling reaction as the key steps.
ChemInform Abstract: CuBr‐Promoted Tandem Cyclization/Trifluoromethylation of 2‐Alkynylanilines: Efficient Synthesis of 3‐Trifluoromethylindoles.
Authors: Ge Guangcun , Huang Xiaojun , Ding Changhua , Li Hao , Wan Shili , Hou Xuelong 
Published: February 2015

AbstractThe title compounds (III) are obtained by using tandem cyclization/trifluoromethylation of 2‐alkynylanilines using Umemoto′s reagent (II) under mild reaction conditions.
ChemInform Abstract: Choline Chloride Based Eutectic Solvents: Direct C‐3 Alkenylation/Alkylation of Indoles with 1,3‐Dicarbonyl Compounds.
Authors: Sanap Anita Kailas , Shankarling Ganapati Subray 
Published: February 2015

AbstractThe deep eutectic solvent derived from choline chloride and oxalic acid, is bio‐degradable, non‐toxic, insensitive towards moisture, recyclable, and cost‐effective.
ChemInform Abstract: Stereoselective Synthesis of O‐Tosyl Azabicyclic Derivatives via Aza Prins Reaction of Endocyclic N‐Acyliminium Ions: Application to the Total Synthesis of (.+‐.)‐Epi‐indolizidine 167B and 209D.
Authors: Saikia Anil K. , Indukuri Kiran , Das Jagadish 
Published: February 2015

AbstractThe synthesis of O‐tosylated azabicyclic compounds via Prins cyclization in which the p‐toluene sulfonic acid acts as a Broensted acid as well as a nucleophile is reported.
ChemInform Abstract: A Facile and Practical One‐Pot Synthesis of [1,2,4]Triazolo[4,3‐a]pyridines.
Authors: Vadagaonkar Kamlesh S. , Murugan Kaliyappan , Chaskar Atul C. , Bhate Prakash M. 
Published: February 2015

AbstractInstead of NBS and DBU, trichloroisocyanuric acid or hydroxy(tosyloxy)iodobenze are used as well, delivering the products in essentially identical yields.
ChemInform Abstract: Straightforward Synthesis of Various 2,3‐Diarylimidazo[1,2‐a]pyridines in PEG400 Medium Through One‐Pot Condensation and C—H Arylation.
Authors: Hiebel Marie‐Aude , Fall Yacoub , Scherrmann Marie‐Christine , Berteina‐Raboin Sabine 
Published: February 2015

AbstractMicrowave assisted condensation of 2‐aminopyridines with α‐bromoketones provides 2‐arylimidazopyridines.
ChemInform Abstract: Fe‐Catalyzed Direct Dithioacetalization of Aldehydes with 2‐Chloro‐1,3‐dithiane.
Authors: Lai Junshan , Du Wenbin , Tian Lixia , Zhao Changgui , She Xuegong , Tang Shouchu 
Published: February 2015

AbstractNotable advantages of the title process are mild reaction conditions and good to excellent yields.
ChemInform Abstract: Mechanistic Insights into the Palladium‐Catalyzed Domino Synthesis of 10,11‐Dihydro‐5H‐dibenzo[b,e][1,4]diazepines.
Authors: Laha Joydev K. , Satyanarayana Tummalapalli K. S. , Gupta Ankur 
Published: February 2015

AbstractA Pd‐catalyzed cyclocondensation of o‐phenylenediamines and 2‐bromobenzyl bromides is described to allow the synthesis of a range of substituted dibenzodiazepines.
ChemInform Abstract: Asymmetric Formation of Bridged Benzoxazocines Through an Organocatalytic Multicomponent Dienamine‐Mediated One‐Pot Cascade.
Authors: Ransborg Lars Krogager , Overgaard Mette , Hejmanowska Joanna , Barfuesser Sebastian , Joergensen Karl Anker , Albrecht Lukasz 
Published: February 2015

AbstractA novel enantioselective one‐pot synthesis of bridged benzoxazocines from salicylaldehydes, anilines, and α,β‐unsaturated aldehydes using a L‐prolinol derivative as catalyst is presented.
ChemInform Abstract: Metal‐Free sp3 C—H Functionalization: A Novel Approach for the Syntheses of Selenide Ethers and Thioesters from Methyl Arenes.
Authors: Badsara Satpal Singh , Liu Yi‐Chen , Hsieh Ping‐An , Zeng Jing‐Wen , Lu Shao‐Yi , Liu Yi‐Wei , Lee Chin‐Fa 
Published: February 2015

AbstractCoupling of diphenylsulfide (XVIIIa) with ethylbenzene (VI) provides the thioether (XVIII) and none of the corresponding thioester.
ChemInform Abstract: Total Synthesis of Callipeltin B and M, Peptidyl Marine Natural Products.
Authors: Kikuchi Mari , Konno Hiroyuki 
Published: February 2015

AbstractThe total synthesis of linear callipeltin M (I) and cyclic callipeltin B (II) by the combination of Fmac solid‐phase peptide synthesis and cyclization and deprotection in solution phase is described.
ChemInform Abstract: Acyclic Congeners from Actinoalloteichus cyanogriseus Provide Insights into Cyclic Bipyridine Glycoside Formation.
Authors: Fu Peng , Zhu Yiguang , Mei Xiangui , Wang Yi , Jia Haijian , Zhang Changsheng , Zhu Weiming 
Published: February 2015

AbstractIsolation and structural characterization of four new acyclic bipyridine glycosides, cyanogrisides E (Ia), F (Ib), G (IIa), and H (IIb) are described.
ChemInform Abstract: A Neighboring Group Participation Strategy: Direct and Highly Diastereoselective Synthesis of 2‐Substituted and 2,2‐Bisubstituted Perhydrofuro[2,3‐b]pyran Derivatives.
Authors: Ma Xiaofeng , Tang Qin , Ke Jun , Zhang Jichao , Yang Xinglong , Shen Xudong , Shao Huawu 
Published: February 2015

AbstractThe stereochemistry of the products is established by extensive NMR experiments and X‐ray analysis of compound (IX).
ChemInform Abstract: Synthesis of (‐)‐Pseudotabersonine, (‐)‐Pseudovincadifformine, and (+)‐Coronaridine Enabled by Photoredox Catalysis in Flow.
Authors: Beatty Joel W. , Stephenson Corey R. J. 
Published: February 2015

AbstractThe alkaloids (‐)‐pseudotabersonine (I), (‐)‐pseudovincadifformine (II) and (+)‐coronaridine (III) are synthesized from commercially available (+)‐catharanthine by Ir‐catalyzed photoredox reaction.
ChemInform Abstract: Total Synthesis of (‐)‐Crinipellin A.
Authors: Kang Taek , Song Seog Boem , Kim Won‐Yeob , Kim Byung Gyu , Lee Hee‐Yoon 
Published: February 2015

AbstractThe first asymmetric total synthesis of (‐)‐crinipellin A from 2‐methyl‐2‐cyclopenten‐1‐one is described.
ChemInform Abstract: Difluoromethylation and Trifluoromethylation Reagents Derived from Tetrafluoroethane β‐Sultone: Synthesis, Reactivity and Applications
Authors: Zhang Cheng‐Pan , Chen Qing‐Yun , Guo Yong , Xiao Ji‐Chang , Gu Yu‐Cheng 
Published: February 2015

AbstractReview: 419 refs.
Comprehensive mutation profiling by next‐generation sequencing of effusion fluids from patients with high‐grade serous ovarian carcinoma
Authors: Shah Ronak H. , Scott Sasinya N. , Brannon A. Rose , Levine Douglas A. , Lin Oscar , Berger Michael F. 
Published: February 2015

BACKGROUNDMutation analysis for personalized treatment has become increasingly important in the management of different types of cancer. The advent of new DNA extraction protocols and sequencing platforms with reduced DNA input requirements might allow the use of cytology specimens for high‐throughput mutation analysis. In this study, the authors evaluated the use of effusion fluid for next‐generation sequencing‐based, multigene mutation profiling.METHODSFour specimens from each of 5 patients who had at least stage III, high‐grade serous ovarian carcinoma were selected: effusion fluid; frozen tumor; formalin‐fixed, paraffin embedded tumor; and matched normal blood. Frozen tumors from each patient were previously characterized by The Cancer Genomic Atlas (TCGA). DNA was extracted from all specimens and was sequenced using a custom hybridization capture‐based assay. Genomic alterations were compared among all specimens from each patient as well as with mutations reported in TCGA for the same tumors.RESULTSIn total, 17 distinct somatic mutations were identified in the cohort. Ten of 17 mutations were reported in TCGA and were called in all 3 malignant specimens procured from the patients. Of the remaining 7 mutations, 2 were called in all 3 specimens, and the other 5 were sample‐specific. Two mutations were detected only in the cytology specimens. Copy number profiles were concordant among the tumors analyzed.CONCLUSIONSCytology specimens represent suitable material for high‐throughput sequencing, because all mutations described by TCGA were independently identified in the effusion fluid. Differences in mutations detected in samples procured from the same patient may reflect tumor heterogeneity. Cancer (Cancer Cytopathol) 2015;123:289–97. © 2015 American Cancer Society.
Ionic Fluids Containing Both Strongly and Weakly Interacting Ions of the Same Charge Have Unique Ionic and Chemical Environments as a Function of Ion Concentration
Authors: Wang Hui , Kelley Steven P. , Brantley Jimmy W. , Chatel Gregory , Shamshina Julia , Pereira Jorge F. B. , Debbeti Varun , Myerson Allan S. , Rogers Robin D. 
Published: February 2015

AbstractLiquid multi‐ion systems made by combining two or more salts can exhibit charge ordering and interactions not found in the parent salts, leading to new sets of properties. This is investigated herein by examining a liquid comprised of a single cation, 1‐ethyl‐3‐methylimidazolium ([C2mim]+), and two anions with different properties, acetate ([OAc]−) and bis(trifluoromethylsulfonyl)imide ([NTf2]−). NMR and IR spectroscopy indicate that the electrostatic interactions are quite different from those in either [C2mim][OAc] or [C2mim][NTf2]. This is attributed to the ability of [OAc]− to form complexes with the [C2mim]+ ions at greater than 1:1 stoichiometries by drawing [C2mim]+ ions away from the less basic [NTf2]− ions. Solubility studies with molecular solvents (ethyl acetate, water) and pharmaceuticals (ibuprofen, diphenhydramine) show nonlinear trends as a function of ion content, which suggests that solubility can be tuned through changes in the ionic compositions.
Polar Group and Defect Engineering in a Metal–Organic Framework: Synergistic Promotion of Carbon Dioxide Sorption and Conversion
Authors: Jiang Zhuo‐Rui , Wang Hengwei , Hu Yingli , Lu Junling , Jiang Hai‐Long 
Published: February 2015

AbstractA sulfone‐functionalized metal–organic framework (MOF), USTC‐253, has been synthesized that exhibits a much higher CO2 uptake capacity (168–182 %) than the corresponding unfurnished MOFs. The introduction of trifluoroacetic acid (TFA) during the synthesis of USTC‐253 affords defect‐containing USTC‐253‐TFA with exposed metal centers, which has an increased CO2 uptake (167 %) compared to pristine USTC‐253. USTC‐253‐TFA exhibits a very high ideal adsorption solution theory selectivity (S=75) to CO2 over N2 at 298 K. In addition, USTC‐253‐TFA demonstrates good catalytic activity and recyclability in the cycloaddition of CO2 and epoxide at room temperature under 1 bar CO2 pressure as a result of the presence of Lewis and Brønsted acid sites, which were evaluated by diffuse reflectance infrared Fourier transform spectroscopy with a CO probe molecule. We propose that the CO2 adsorption capability has a positive correlation with the catalytic performance toward CO2 conversion.
Quantitative image analysis of cell colocalization in murine bone marrow
Authors: Mokhtari Zeinab , Mech Franziska , Zehentmeier Sandra , Hauser Anja E. , Figge Marc Thilo 
Published: February 2015

AbstractLong‐term antibody production is a key property of humoral immunity and is accomplished by long‐lived plasma cells. They mainly reside in the bone marrow, whose importance as an organ hosting immunological memory is becoming increasingly evident. Signals provided by stromal cells and eosinophils may play an important role for plasma cell maintenance, constituting a survival microenvironment. In this joint study of experiment and theory, we investigated the spatial colocalization of plasma cells, eosinophils and B cells by applying an image‐based systems biology approach. To this end, we generated confocal fluorescence microscopy images of histological sections from murine bone marrow that were subsequently analyzed in an automated fashion. This quantitative analysis was combined with computer simulations of the experimental system for hypothesis testing. In particular, we tested the observed spatial colocalization of cells in the bone marrow against the hypothesis that cells are found within available areas at positions that were drawn from a uniform random number distribution. We find that B cells and plasma cells highly colocalize with stromal cells, to an extent larger than in the simulated random situation. While B cells are preferentially in contact with each other, i.e., form clusters among themselves, plasma cells seem to be solitary or organized in aggregates, i.e., loosely defined groups of cells that are not necessarily in direct contact. Our data suggest that the plasma cell bone marrow survival niche facilitates colocalization of plasma cells with stromal cells and eosinophils, respectively, promoting plasma cell longevity. © 2015 International Society for Advancement of Cytometry
Mapping the development of cerebellarPurkinje cells in zebrafish
Authors: Hamling Kyla R. , Tobias Zachary J.C. , Weissman Tamily A. 
Published: February 2015

ABSTRACTThe cells that comprise the cerebellum perform a complex integration of neural inputs to influence motor control and coordination. The functioning of this circuit depends upon Purkinje cells and other cerebellar neurons forming in the precise place and time during development. Zebrafish provide a useful platform for modeling disease and studying gene function, thus a quantitative metric of normal zebrafish cerebellar development is key for understanding how gene mutations affect the cerebellum. To begin to quantitatively measure cerebellar development in zebrafish, we have characterized the spatial and temporal patterning of Purkinje cells during the first 2 weeks of development. Differentiated Purkinje cells first emerged by 2.8 days post fertilization and were spatially patterned into separate dorsomedial and ventrolateral clusters that merged at around 4 days. Quantification of the Purkinje cell layer revealed that there was a logarithmic increase in both Purkinje cell number as well as overall volume during the first 2 weeks, while the entire region curved forward in an anterior, then ventral direction. Purkinje cell dendrites were positioned next to parallel fibers as early as 3.3 days, and Purkinje cell diameter decreased significantly from 3.3 to 14 days, possibly due to cytoplasmic reappropriation into maturing dendritic arbors. A nearest neighbor analysis showed that Purkinje cells moved slightly apart from each other from 3 to 14 days, perhaps spreading as the organized monolayer forms. This study establishes a quantitative spatiotemporal map of Purkinje cell development in zebrafish that provides an important metric for studies of cerebellar development and disease. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 75: 1174–1188, 2015
Ionic liquids improve the selective synthesis of hydrophilic glyceryl ferulates by the enzymatic transesterification of ethyl ferulate with monostearin: Comparison with organic solvents
Authors: Sun Shangde , Hu Bingxue , Song Fanfan , Bi Yanlan 
Published: February 2015

Glyceryl ferulates (GMF + GDF, combination of glyceryl monoferulate and glyceryl diferulate), and feruloylated acylglycerols (FMAG + FDAG, combination of feruloylated monoacylglycerols, and feruloylated diacylglycerols) are hydrophilic and lipophilic derivatives of ferulic acid (FA), which can be used as antioxidants and UV absorbers in food and other fields. In this study, the effect of ionic liquids (ILs) and organic solvents on the enzymatic transesterification of ethyl ferulate (EF) with monostearin was investigated. The effects of reaction time, temperature, and enzyme load on EF conversion and reaction selectivity were also evaluated and optimized using response surface methodology. Among ILs tested, high EF conversion (98.4 ± 0.5%), and reaction selectivity for GMF + GDF (0.81) were obtained in [Emim]TF2N; and for organic solvents tested, EF conversion (72.7 ± 1.5%) and reaction selectivity (0.75) were achieved in n‐hexane. Results also showed that, compared with n‐hexane, [Emim]TF2N can improve the selective synthesis of GMF + GDF, and [Emim]TF2N also shows significant protection on the enzyme inactivation at high temperature (90°C). The activation energies (Ea) of hydrolysis to form GMF + GDF and transesterification to form FMAG + FDAG were 51.98 and 43.49 kJ/mol in [Emim]TF2N, 72.35, and 53.11 kJ/mol in n‐hexane, respectively. , , and in [Emim]TF2N were 0.01, 0.19 mol/L, and 4.13 × 10−4mol/(L · min), respectively.Practical applications: In this work, FMAG + FDAG and GMF + GDF were prepared by enzymatic transesterification of EF with monostearin. During the reaction, the competitive reaction of the hydrolysis of monostearin to form hydrophilic GMF + GDF and the transesterification of monostearin and EF to form lipophilic FMAG + FDAG take place in parallel. The effect of ionic liquids (ILs) and organic solvents on the competitive reaction was investigated. Compared with organic solvent (n‐hexane), IL ([Emim]TF2N) is apt to the formation of hydrophilic GMF + GDF; and [Emim]TF2N shows remarkably protective effect on the inactivation of enzyme at high temperature up to 90°C than that (65°C) of n‐hexane. This study can give information about the influence of different reaction media on the enzymatic transesterification and reaction selectivity.Enzymatic transesterification of ethyl ferulate (EF) with monostearin to produce hydrophilic glyceryl monoferulate (GMF)+glyceryl diferulate (GDF) and lipophilic feruloylated monoacylglycerols (FMAG)+feruloylated diacylglycerols (FDAG) in ionic liquids or organic solvents.
Indium‐Catalyzed Reductive Sulfidation of Aromatic Carboxylic Acids and Aldehydes with Elemental Sulfur to Prepare Symmetrical Benzyl Sulfides
Authors: Miyazaki Takahiro , Nishino Kota , Yoshimoto Shunsuke , Ogiwara Yohei , Sakai Norio 
Published: February 2015

AbstractDescribed herein is a direct approach to symmetrical thioethers from either aromatic carboxylic acids or aromatic aldehydes with elemental sulfur (S8) by using a reducing system combined with InI3 and 1,1,3,3‐tetramethyldisiloxane (TMDS). This sulfidation does not require functionalized sulfur reagents, such as sulfides, disulfides, or metal sulfides, and it simultaneously forms two carbon–sulfur bonds in a single catalytic system.
Chiral Phase‐Transfer‐Catalyzed Intramolecular aza‐Michael Reactions for the Asymmetric Synthesis of Isoindolinones
Authors: Lebrun Stéphane , Sallio Romain , Dubois Mélanie , Agbossou‐Niedercorn Francine , Deniau Eric , Michon Christophe 
Published: February 2015

AbstractAsymmetric intramolecular aza‐Michael reactions catalyzed by cinchoninium phase‐transfer organocatalysts are used for the synthesis of optically active isoindolinones. Selected oligomeric cinchoninium salts are efficient and selective catalysts for the intramolecular addition of alkenylated benzamide substrates. The resulting compounds are useful intermediates for the synthesis and development of benzodiazepine‐receptor agonists.
A Cascade Aza‐Cope/Aza‐Prins Cyclization Leading to Piperidine Derivatives
Authors: Nallasivam Jothi L. , Fernandes Rodney A. 
Published: February 2015

AbstractThe cascade aza‐Cope/aza‐Prins cyclization of homoallylamines to give substituted piperidines has been explored. The use of glyoxalic acid as the carbonyl component afforded bicyclic structures as a result of the internal carboxylate anion trapping the intermediate cation. The unimolecular bis‐, tris‐, and tetrakis(homoallylamine)s efficiently delivered the appended bis‐, tris‐ and tetrakis(piperidine‐4‐ol)s (tripod and crucifix shape, respectively) as new entities. The latter compound served as an excellent ligand in the Suzuki–Miyaura cross‐coupling reaction to synthesize incrustoporin.
Radical Decarboxylative Fluorination of Aryloxyacetic Acids Using N‐Fluorobenzenesulfonimide and a Photosensitizer
Authors: Leung Joe C. T. , Sammis Glenn M. 
Published: February 2015

AbstractFluorinated methoxy arenes are emerging as important motifs in both agrochemicals and pharmaceuticals. A novel technique for the synthesis of monofluoromethoxy arenes through the direct fluorodecarboxylation of carboxylic acids was developed that uses photosensitizers and N‐fluorobenzenesulfonimide (NFSI). Utilization of the oxidatively mild fluorine transfer agent NFSI enabled the synthesis of fluoromethyl ethers that were previously inaccessible with decarboxylative fluorinations performed with Selectfluor. Mechanistic studies are consistent with the photosensitizer effecting oxidation of the aryloxyacetic acid.