bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thein vivoperformance of an alkali‐free bioactive glass for bone grafting,FastOs®BG, assessed with an ovine model
Authors: Cortez Paulo P. , Brito Ana F. , Kapoor Saurabh , Correia Ana F. , Atayde Luis M. , Dias‐Pereira Patrícia , Maurício Ana Colette , Afonso Américo , Goel Ashutosh , Ferreira José M.F. 
Published: September 2015

AbstractAlthough bioactive glasses are successfully used as bone substitutes, recent studies have revealed that the high alkali content in these glasses leads to fastin vivodegradation rates that may not match the rate of new bone ingrowth. This prompted us to design and develop novel bioactive glasses that are devoid of alkali but still demonstrate high bioactivityin vitro. This article describes thein vivoperformance of an alkali‐free bioactive glass with the following composition (Wt %): 13.03 MgO–33.98 CaO–13.37 P2O5−38.84 SiO2−0.77 CaF2(labelled as FastOs®BG). An animal model was used to assess thein vivoperformance of FastOs®BG, using 45S5 Bioglass®as control. The evaluation was performed through implantation of FastOs®BG and 45S5 Bioglass®, during one month, in femoral bone defects in sheep. Subcutaneous implantation of both glasses was also performed in order to assess tissue response through a standardized method. Histological and scanning electron microscopy assessment of retrieved subcutaneous and bone samples demonstrated that FastOs®BG is biocompatible, osteoconductive, that it can be osteointegrated, and that it is more slowly resorbed than 45S5 Bioglass®. These features suggest that FastOs®BG is a potential candidate for bone grafting. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 30–38, 2017.
Stabilization of Oncostatin‐M mRNA by Binding of Nucleolin to a GC‐Rich Element in Its 3′UTR
Authors: Saha Sucharita , Chakraborty Alina , Bandyopadhyay Sumita Sengupta 
Published: September 2015

ABSTRACTOncostatin‐M (OSM) is a patho‐physiologically important pleiotropic, multifunctional cytokine. OSM mRNA sequence analysis revealed that its 3′UTR contains three highly conserved GC‐rich cis‐elements (GCREs) whose role in mRNA stability is unidentified. In the present study, the functional role of the proximal GC‐rich region of osm 3′‐UTR (GCRE‐1) in post‐transcriptional regulation of osm expression in U937 cells was assessed by transfecting construct containing GCRE‐1 at 3′‐end of a fairly stable reporter gene followed by analysis of the expression of the reporter. GCRE‐1 showed mRNA destabilizing activity; however, upon PMA treatment the reporter message containing GCRE‐1 was stabilized. This stabilization is owing to a time‐dependent progressive binding of trans‐factors (atleast five proteins) to GCRE‐1 post‐PMA treatment. Nucleolin was identified as one of the proteins in the RNP complex of GCRE‐1 with PMA‐treated U937 cytosolic extracts by oligo‐dT affinity chromatography of poly‐adenylated GCRE‐1. Immuno‐blot revealed time‐dependent enhancement of nucleolin in the cytoplasm which in turn directly binds GCRE‐1. RNA co‐immunoprecipitation confirmed the GCRE‐1‐nucleolin interaction in vivo. To elucidate the functional role of nucleolin in stabilization of osm mRNA, nucleolin was overexpressed in U937 cells and found to stabilize the intrinsic osm mRNA, where co‐transfection with the reporter containing GCRE‐1 confirms the role of GCRE‐1 in stabilization of the reporter mRNA. Thus, in conclusion, the results asserted that PMA treatment in U937 cells leads to cytoplasmic translocation of nucleolin that directly binds GCRE‐1, one of the major GC‐rich instability elements, thereby stabilizing the osm mRNA. J. Cell. Biochem. 117: 988–999, 2016. © 2015 Wiley Periodicals, Inc.
Extractables and leachables issues with the application of single use technology in the biopharmaceutical industry
Authors: Gao Ying , Allison Nigel 
Published: September 2015

AbstractSingle‐use technology has been adopted widely in bioprocess development and biopharmaceutical manufacture in recent years. While the benefits of such technologies are well recognized, there are significant concerns regarding extractables and leachables arising from the components of single‐use systems owing to their potential effect on product quality and patient health. Their impact on drug product quality and safety must be clearly understood before adopting disposable technologies into manufacture. A risk assessment is normally required to assess the probability of extractables and leachables migrating into the product stream and their potential risk to the patient. Generic information provided by suppliers may be useful but its relevance to individual applications needs to be demonstrated. Standardization of extractables and leachables testing and approaches to risk assessment has been discussed between the biopharmaceutical industry and regulators. This perspective reviews the current status of extractables and leachables studies within the biopharmaceutical industry and the general approaches employed for risk evaluation associated with the application of single‐use technology. © 2015 Society of Chemical Industry
Complexity and predictability of the monthly Western Mediterranean Oscillation index
Authors: Lana X. , Burgueño A. , Martínez M. D. , Serra C. 
Published: September 2015

ABSTRACTThe complexity, predictability and predictive instability of the Western Mediterranean Oscillation index (WeMOi) at monthly scale, years 1856–2000, are analysed from the viewpoint of monofractal and multifractal theories. The complex physical mechanism is quantified by: (1) the Hurst exponent, H, of the rescaled range analysis; (2) correlation and embedding dimensions, μ* and dE, together with Kolmogorov entropy, κ, derived from the reconstruction theorem; and (3) the critical Hölder exponent, αo, the spectral width, W, and the asymmetry of the multifractal spectrum, f(α). The predictive instability is described by the Lyapunov exponents, λ, and the Kaplan–Yorke dimension, DKY, while the self‐affine character is characterized by the Hausdorff exponent, Ha. Relationships between the exponent β, which describes the dependence of the power spectrum S(f) on frequency f, and the Hurst and Hausdorff exponents suggest fractional Gaussian noise (fGn) as a right simulation of empiric WeMOi. Comparisons are made with monthly North‐Atlantic Oscillation and Atlantic Multidecadal Oscillation indices. The analysis is complemented with an ARIMA(p,1,0) autoregressive process, which yields a more accurate prediction of WeMOi than that derived from fGn simulations.
How the variance of some extraction variables may affect the quality of espresso coffees served in coffee shops
Authors: Severini Carla , Derossi Antonio , Fiore Anna G , De Pilli Teresa , Alessandrino Ofelia , Del Mastro Arcangela 
Published: September 2015

AbstractBACKGROUNDTo improve the quality of espresso coffee, the variables under the control of the barista, such as grinding grade, coffee quantity and pressure applied to the coffee cake, as well as their variance, are of great importance. A nonlinear mixed effect modeling was used to obtain information on the changes in chemical attributes of espresso coffee (EC) as a function of the variability of extraction conditions.RESULTSDuring extraction, the changes in volume were well described by a logistic model, whereas the chemical attributes were better fit by a first‐order kinetic. The major source of information was contained in the grinding grade, which accounted for 87–96% of the variance of the experimental data. The variability of the grinding produced changes in caffeine content in the range of 80.03 mg and 130.36 mg when using a constant grinding grade of 6.5.CONCLUSIONThe variability in volume and chemical attributes of EC is large. Grinding had the most important effect as the variability in particle size distribution observed for each grinding level had a profound effect on the quality of EC. Standardization of grinding would be of crucial importance for obtaining all espresso coffees with a high quality. © 2015 Society of Chemical Industry
Iron migration from undamaged and dented juice tinplate cans
Authors: Veríssimo Marta IS , Silva Rui PO , Gomes Maria Teresa SR 
Published: September 2015

AbstractBACKGROUNDIron migration from tinplate cans to pineapple drink was studied over time using flame atomic absorption spectroscopy, taking into consideration storage temperature, sell‐by date and can condition (dented/undamaged). An organoleptic test, at the sell‐by date, was also performed.RESULTAnalysis of iron in drinks from tinplate cans, glass and polyethylene terephthalate (PET) bottles was performed up until the sell‐by date. For undamaged canned drinks stored at room temperature, iron was found to remain constant at 0.23 ± 0.01 mg L−1, from the 24th day until 1 year after production. Iron found in glass and PET bottles also remained constant until the sell‐by date, at 0.15 ± 0.04 and 0.12 ± 0.04 mg L−1, respectively. However, migration of iron from dented cans was found to be significant. Twelve months after production, iron content in dented cans, stored at room temperature (22 °C) and in a refrigerator chamber (4 °C) was 14.4 ± 1.0 and 5.5 ± 0.4 mg L−1, respectively.CONCLUSIONResults showed that for a 35 kg child the intake of three damaged canned drinks may contribute to more than 50% of the iron provisional maximum tolerance daily intake. © 2015 Society of Chemical Industry
Preschool Israeli Children Exposed to Rocket Attacks: Assessment, Risk, and Resilience
Authors: Wolmer Leo , Hamiel Daniel , Versano‐Eisman Tali , Slone Michelle , Margalit Nitzan , Laor Nathaniel 
Published: September 2015

AbstractPreschool children are among the most vulnerable populations to adversity. This study described the effects of 4 weeks of daily exposure to rocket attacks on children living on Israel's southern border. Participants enrolled in this study were 122 preschool children (50% boys) between the ages 3 and 6 years from 10 kindergartens. We assessed mothers' report of children's symptoms according to the DSM‐IV and alternative criteria resembling the DSM‐5 criteria for posttraumatic stress disorder (PTSD), general adaptation, traumatic exposure, and stressful life events 3 months after the war. The prevalence of PTSD was lower when the diagnosis was derived from the DSM‐IV (4%) than from the DSM‐5 criteria (14%). Mothers of children with 4 or more stressful life events reported more functional impairment in social, occupational, and other important areas of functioning compared to children with 0 or 1 stressful life event. Children with more severe exposure showed more severe symptoms and mothers had more concerns about the child's functioning (ηp2 = .09–.25). Stressful life events and exposure to traumatic experiences accounted for 32% of the variance in PTSD and 19% of the variance in the adaptation scale. Results were explored in terms of risk and resilience factors.
Blackout Drinking Predicts Sexual Revictimization in a College Sample of Binge‐Drinking Women
Authors: Valenstein‐Mah Helen , Larimer Mary , Zoellner Lori , Kaysen Debra 
Published: September 2015

AbstractSexual victimization is prevalent on U.S. college campuses. Some women experience multiple sexual victimizations with heightened risk among those with prior victimization histories. One risk factor for sexual revictimization is alcohol use. Most research has focused on associations between alcohol consumption and revictimization. The current study's objective was to understand potential mechanisms by which drinking confers risk for revictimization. We hypothesized that specific drinking consequences would predict risk for revictimization above and beyond the quantity of alcohol consumed. There were 162 binge‐drinking female students (mean age = 20.21 years, 71.3% White, 36.9% juniors) from the University of Washington who were assessed for baseline victimization (categorized as childhood vs. adolescent victimization), quantity of alcohol consumed, and drinking consequences experienced, then assessed 30 days later for revictimization. There were 40 (24.6%) women who were revictimized in the following 30 days. Results showed that blackout drinking at baseline predicted incapacitated sexual revictimization among women previously victimized as adolescents, after accounting for quantity of alcohol consumed (OR = 1.79, 95% CI [1.07, 3.01]). Other drinking consequences were not strongly predictive of revictimization. Adolescent sexual victimization was an important predictor of sexual revictimization in college women; blackout drinking may confer unique risk for revictimization.
A golden experience: Fifty years of experience managing the frontal sinus
Authors: Chen Philip G. , Wormald Peter‐John , Payne Spencer C. , Gross William E. , Gross Charles W. 
Published: September 2015

Objectives/HypothesisThe frontal sinus is one of the most anatomically complex and inaccessible of the paranasal sinuses. As a result, surgeons have continually tried to improve surgical management of the frontal sinus. The senior author (c.w.g.) shares 50 years of experience managing the frontal sinus.Data SourcesPubMed literature search.Review MethodsReview of the literature regarding landmark innovations in frontal sinus surgery.ResultsOpen approaches established that the frontal sinus is accessible, and in certain circumstances, such as with large osteoma or papilloma, are still required. The endoscope changed the surgical landscape and allowed for greater finesse and decreased morbidity. Sinus balloon dilation is the newest change in frontal sinus management and shows promise in properly selected cases.ConclusionSurgery of the frontal sinus continues to evolve and improve. Although there are new techniques, the older techniques are still pertinent. Laryngoscope, 126:802–807, 2016
Ultrabroadband superoscillatory lens composed by plasmonic metasurfaces for subdiffraction light focusing
Authors: Tang Dongliang , Wang Changtao , Zhao Zeyu , Wang Yanqin , Pu Mingbo , Li Xiong , Gao Ping , Luo Xiangang 
Published: September 2015

AbstractConventional optics is diffraction limited due to the cutoff of spatial frequency components, and evanescent waves allow subdiffraction optics at the cost of complex near‐field manipulation. Recently, optical superoscillatory phenomena were employed to realize superresolution lenses in the far field, but suffering from very narrow working wavelength band due to the fragility of the superoscillatory light field. Here, an ultrabroadband superoscillatory lens (UBSOL) is proposed and realized by utilizing the metasurface‐assisted law of refraction and reflection in arrayed nanorectangular apertures with variant orientations. The ultrabroadband feature mainly arises from the nearly dispersionless phase profile of transmitted light through the UBSOL for opposite circulation polarization with respect to the incident light. It is demonstrated in experiments that subdiffraction light focusing behavior holds well with nearly unchanged focal patterns for wavelengths spanning across visible and near‐infrared light. This method is believed to find promising applications in superresolution microscopes or telescopes, high‐density optical data storage, etc.image
Stability prediction for milling process with multiple delays using an improved semi‐discretization method
Authors: Jin Gang , Qi Houjun , Cai Yujun , Zhang Qichang 
Published: September 2015

AbstractMilling chatter leads to a poor surface finish, premature tool wear, and potential damage to the machine or tool. Thus, it is desirable to predict and avoid the onset of this instability. Considering that the stability of milling with variable pitch cutter or tool runout case is characterized by multiple delays, in this paper, an improved semi‐discretization method is proposed to predict the stability lobes for milling processes with multiple delays. Taking the variable pitch milling, for example, a comparisonwith prior methods is conducted to verify the accuracy and efficiency of the proposed approach for the stability prediction both in low and high radial immersion ratios. In addition, the rate of convergence of the proposed method is also evaluated. The results show that the proposed method has high computational efficiency. Copyright © 2015 John Wiley & Sons, Ltd.
KDAC8 substrate specificity quantified by a biologically relevant, label‐free deacetylation assay
Authors: Toro Tasha B. , Watt Terry J. 
Published: September 2015

AbstractAnalysis of the human proteome has identified thousands of unique protein sequences that contain acetylated lysine residues in vivo. These modifications regulate a variety of biological processes and are reversed by the lysine deacetylase (KDAC) family of enzymes. Despite the known prevalence and importance of acetylation, the details of KDAC substrate recognition are not well understood. While several methods have been developed to monitor protein deacetylation, none are particularly suited for identifying enzyme‐substrate pairs of label‐free substrates across the entire family of lysine deacetylases. Here, we present a fluorescamine‐based assay which is more biologically relevant than existing methods and amenable to probing substrate specificity. Using this assay, we evaluated the activity of KDAC8 and other lysine deacetylases, including a sirtuin, for several peptides derived from known acetylated proteins. KDAC8 showed clear preferences for some peptides over others, indicating that the residues immediately surrounding the acetylated lysine play an important role in substrate specificity. Steady‐state kinetics suggest that the sequence surrounding the acetylated lysine affects binding affinity and catalytic rate independently. Our results provide direct evidence that potential KDAC8 substrates previously identified through cell based experiments can be directly deacetylated by KDAC8. Conversely, the data from this assay did not correlate well with predictions from previous screens for KDAC8 substrates using less biologically relevant substrates and assay conditions. Combining results from our assay with mass spectrometry‐based experiments and cell‐based experiments will allow the identification of specific KDAC‐substrate pairs and lead to a better understanding of the biological consequences of these interactions.
The Importance of Monitoring Patients’ Responses to Medications: Increased Arousal after Administration of Zolpidem in Those with Hypoxic Ischemic Encephalopathy—A Case Study
Authors: Duraski Sylvia A. 
Published: September 2015

Abstract
In rehabilitation, nurses are the first team members to note or be told when a patient is having a positive or negative response to a medication. In brain injury medicine, medications are often used to augment cognitive or physical rehabilitation by increasing alertness, attention, focus, concentration, improving sleep, decreasing agitation, or easing spasticity and rigidity. Rehabilitation nurses not only should be aware of how medications work but also how medications may work differently in a chronically ill or disabled population. This article describes a 51-year-old man who suffered a hypoxic ischemic brain injury and how his neurological complications were managed with a nonbenzodiazepine medication which the Food and Drug Administration approved for the treatment of insomnia.
Pain, Physical Function, and Health in Patients With Knee Osteoarthritis
Authors: Huang Kuang-Hui , Hsieh Ru-Lan , Lee Wen-Chung 
Published: September 2015

Abstract

Purpose:
The aim of this study was to evaluate the associations between pain and physical functional limitation and health status in patients with knee osteoarthritis (OA).

Design:
A correlational study.

Methods:
In a convenience sample of 73 patients with knee OA, pain and physical function were assessed using the Western Ontario and McMaster University Osteoarthritis Index. Health status was evaluated using multiple instruments under the International Classification of Functioning, Disability, and Health framework.

Findings:
In the study of patients with knee OA, pain and physical functional limitation exhibited mild to strong associations with health status, including body function and structure (r = .26–.71), activities and participation (r = .24–.88), and personal and environmental factors (r = .24–.62).

Conclusion:
In patients with knee OA, health status is mildly to strongly associated with pain and physical functional limitation.

Clinical Relevance:
Reducing pain and physical functional limitation in patients with knee OA might improve their health status.
Mental representation and the discovery of new strategies
Authors: Csaszar Felipe A. , Levinthal Daniel A. 
Published: September 2015

Research summary: Managers' mental representations affect the perceived payoffs and alternatives that managers consider. Thus, mental representations affect how managers search for profitable strategies as well as the quality of strategies they discover. To study how mental representation and search interact, we formally model the dual search over possible representations and over policy choices of a strategy “landscape.” We analyze when it is preferable to emphasize searching for the best policies rather than the best mental representation, and vice versa. We show that, in the long run, a balance between the two search modes not only results in better expected performance, but also reduces the variation in performance. Additionally, the article describes conditions under which increased accuracy of mental representations can actually worsen firm performance.Managerial summary: Managers' mental representations affect the perceived payoffs and alternatives that managers consider. Thus, mental representations affect the quality of strategies managers can discover. We analyze a computer simulation of how managers use mental representations to search for strategies. This sheds light on how managers should deal with the trade‐off between searching for policies and searching for representations; that is, whether managers should think creatively about how to represent a strategy problem or whether they should just stick to the current problem understanding, and try to find ways to improve performance as suggested by the current representation. We provide insight regarding the balance between the two search modes and describe conditions under which increasingly accurate mental representations can worsen firm performance. Copyright © 2015 John Wiley & Sons, Ltd.
Embodied emotion: the influence of manipulated facial and bodily states on emotive responses
Authors: Price Tom F. , Harmon‐Jones Eddie 
Published: September 2015

A growing body of evidence suggests that certain facial expressions and postures are associated with emotional and motivational responses. This review discusses behavioral, neuroscientific, and cognitive research connecting these bodily movements with emotive responses. General bodily feedback theories of emotion have suggested that manipulated facial expressions and postures influence emotive reactions to stimuli as well as physiological responses such as heart rate, skin conductance, and the temperature of blood entering the brain. More recent evidence suggests that manipulated bodily states influence prefrontal cortical activation and amygdala activation. Even further evidence has suggested that manipulated bodily states influence cognitive processes, such as the speed at which individuals read emotional content, the speed at which they classify information as emotional, and the extent to which they determine emotional information as threatening. Bodily feedback theories may also suggest clinical applications. Bodily feedback theories of emotion therefore have generated research showing that bodily expressions play a pivotal role in our emotive experiences.WIREs Cogn Sci2015, 6:461–473. doi: 10.1002/wcs.1370This article is categorized under:Psychology > Emotion and Motivation