bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nomogram based on liver stiffness and spleen area with ultrasound for posthepatectomy liver failure: A multicenter study
Authors: Cheng Guang-Wen , Fang Yan , Xue Li-Yun , Zhang Yan , Xie Xiao-Yan , Qiao Xiao-Hui , Li Xue-Qi , Guo Jia , Ding Hong 
Published: July 2024

BACKGROUND
Liver stiffness (LS) measurement with two-dimensional shear wave elastography (2D-SWE) correlates with the degree of liver fibrosis and thus indirectly reflects liver function reserve. The size of the spleen increases due to tissue proliferation, fibrosis, and portal vein congestion, which can indirectly reflect the situation of liver fibrosis/cirrhosis. It was reported that the size of the spleen was related to posthepatectomy liver failure (PHLF). So far, there has been no study combining 2D-SWE measurements of LS with spleen size to predict PHLF. This prospective study aimed to investigate the utility of 2D-SWE assessing LS and spleen area (SPA) for the prediction of PHLF in hepatocellular carcinoma (HCC) patients and to develop a risk prediction model.
AIM
To investigate the utility of 2D-SWE assessing LS and SPA for the prediction of PHLF in HCC patients and to develop a risk prediction model.
METHODS
This was a multicenter observational study prospectively analyzing patients who underwent hepatectomy from October 2020 to March 2022. Within 1 wk before partial hepatectomy, ultrasound examination was performed to measure LS and SPA, and blood was drawn to evaluate the patient’s liver function and other conditions. Least absolute shrinkage and selection operator logistic regression and multivariate logistic regression analysis was applied to identify independent predictors of PHLF and develop a nomogram. Nomogram performance was validated further. The diagnostic performance of the nomogram was evaluated with receiver operating characteristic curve compared with the conventional models, including the model for end-stage liver disease (MELD) score and the albumin-bilirubin (ALBI) score.
RESULTS
A total of 562 HCC patients undergoing hepatectomy (500 in the training cohort and 62 in the validation cohort) were enrolled in this study. The independent predictors of PHLF were LS, SPA, range of resection, blood loss, international normalized ratio, and total bilirubin. Better diagnostic performance of the nomogram was obtained in the training [area under receiver operating characteristic curve (AUC): 0.833; 95% confidence interval (95%CI): 0.792-0.873; sensitivity: 83.1%; specificity: 73.5%] and validation (AUC: 0.802; 95%CI: 0.684-0.920; sensitivity: 95.5%; specificity: 52.5%) cohorts compared with the MELD score and the ALBI score.
CONCLUSION
This PHLF nomogram, mainly based on LS by 2D-SWE and SPA, was useful in predicting PHLF in HCC patients and presented better than MELD score and ALBI score.
Penguatan Potensi Kelembagaan Desa Menuju Percepatan Pencapaian Pembangunan Desa Berkelanjutan
Authors: Tui Fenti Prihatini , Ilato Rosman 
Published: July 2024

BUMDes merupakan lembaga yang dibentuk atas dasar prakarsa masyarakat, yang diharapkan dapat mengakomodir kebutuhan dan potensi desa yang pada akhirnya dapat meningkatkan kesejahteraan masyarakat desa. Ini sejalan dengan tujuan (Sustainable Development Goals) SDGs yang telah dicanangkan sebagai upaya untuk mengurangi kemiskinan dan upaya meningkatkan kesejahteraan masyarakat.Fenomena di Desa Huidu Melito menunjukan bahwa potensi yang dimiliki desa yang diharapkan dapat dikelola melalui BUMDes tidak optimal. Keberadaan BUMdes belum dapat memberikan manfaat untuk kesejahteraan masyarakat. Hal ini disebabkan oleh kurangnya kemampuan mengelola keuangan desa dengan tepat, kurangnya kemampuan untuk membuat dan menentukan jenis usaha yang akan dikelola atau ketidakmampuan memanfaatkan potensi yang dimiliki, baik berupa sumber daya alam dan sumber daya manusia (SDM) yang belum memadai dari segi kualitas dan kuantitas.Metode yang digunakan dalam Penguatan Potensi Kelembagaan desa yang digagas oleh Mahasiswa KKN Tematik Desa Membangun Universitas Negeri Gorontalo tahun 2021 adalah dengan metode: (1) sosialiasi dan (2) Pendampingan Pengelolaan Keuangan BUMDes. Kegiatan ini bertujuan untuk (1) Meningkatkan peran serta aparat pemerintah dan masyarakat desa dalam merencanakan kegiatan ekonomi desa, (2) Meningkatkan potensi pengembangan kerjasama desa, (3) Meningkatkan potensi pengembangan BUMDES. Ada pun yang menjadi target sasaran kegiatan ini adalah seluruh Pengurus Bumdes serta aparatur desa.Hasil kegiatan Pengabdian menunjukan bahwa kegiatan sosialisasi dan pendampingan pengelolaan BUMDes yang dilaksanakan oleh Mahasiswa KKN Desa Tematik Universitas Negeri Gorontalo tahun 2021 yang melibatkan pihak Dinas Pemberdayaan Masyarakat dan Desa Pemerintah Daerah Kabupaten Gorontalo Utara terlaksana dengan baik. Melalui Kegiatan Sosialisasi dan Pendampingan yang dilaksanakan, mampu meningkatkan pemahaman, kemampuan dan keterampilan aparat desa dan BUMDes dalam Pengelolaan BUMDes di desa Huidu Melito Kecamatan Tomilito Kabupaten Gorontalo Utara.
Kuliah Kerja Nyata Tematik Desa Membangun Sebagai Bagian Dari Iplementasi Kompetensi Mahasiswa
Authors: Machmoed Buyung Rahmad , Rasyid Abdul 
Published: July 2024

Kuliah Kerja Nyata (KKN) Tematik merupakan kegiatan intrakulikuler yang memadukan pelaksanaan Tri Dharma Perguruan Tinggi dengan metode pemberian pengalaman belajar dan bekerja kepada mahasiswa dalam kegiatan pemberdayaan masyarakat. KKN Tematik Desa Membangun menuntut keterlibatan aktif mahasiswa dalam berdialog secara intensif dengan masyarakat. KKN Tematik ini tidak hanya berorientasi pada alih pengetahuan (transfer of knowledge) kepada masyarakat dan pembelajaran pemberdayaan masyarakat, tetapi juga menanamkan kesadaran (nilai-nilai baru), mencerdaskan masyarakat dengan memperkenalkan pikiran-pikiran kritis kepada masyarakat dalam rangka membangun komunitas (desa) yang lebih partisipatif dan berpihak pada kelestarian lingkungan hidup. Mendorong Pemerintah Desa, Serta Karang Taruna Dalam Mengeluarkan Ide-ide Program Inovasi Desa (PID) yang berkualitas untuk Desa Ilodulunga Kecamatan Anggrek Kabupaten Gorontalo Utara, selain kegiatan tersebut beberapa kegiatan yang dilaksanakan Bersama Masyarakat Desa seperti pentas seni dan olahraga, dan beberapa kegiatan lainnya. Pelaksanaan program KKN tematik ini diharapkan mampu merubah pola pikir masyarakat menjadi masyarakat yang mandiri, tertib, bersih dan membina kedisplinan dalam etos kerja dan gotong royong
Pemberdayaan Masyarakat melalui Pengembangan UMKM Hasil Kerajinan Tangan dari Tanaman Eceng Gondok
Authors: Rahmatiah Rahmatiah , Wiroto Dondick Wicaksono , Lemba Halid , Taan Hapsawati 
Published: July 2024

Tanaman Eceng Gondok, selain memiliki dampak negatif, juga memiliki dampak positif. Salah satu dampak positifnya dapat dimanfaatkan sebagai bahan baku dalam pembuatan kerajinan tangan dengan berbagai bentuk. Pelatihan yang dilaksanakan oleh mahasiswa yang memprogramkan MBKM-Proyek Desa yang dilaksanakan di Kelurahan Dembe 1, diharapkan dapat berkontribusi dalam membangun desa terutama pada pencapaian tujuan yakni: 1) Membantu masyarakat memanfaatkan eceng gondok agar memiliki nilai positif ; 2) Meningkatkan pengetahuan dan keterampilan terkait pemanfaatan eceng gondok: dan 3) Menumbuhkan minat masyarakat dan tenaga kreatifitas dalam mereproduksi eceng gondok.Berdasarkan hasil pelaksanaan Pelatihan Kerajinan eceng Gondok, tim pelaksana menghadapi hambatan-hambatan sebagai berikut: 1) kurangnnya disiplin waktu dari peserta. 2) Kurangnnya peserta yang hadir mengikuti pelatihan; 3) kurangnnya minat masyarakat untuk menekuni usaha yang bergerak dalam pemanfaatan eceng gondok. Produk yang dibuat dalam pelatihan ini berupa hiasan dinding berbahan dasar eceng gondok dengan teknik lukis menggunakan cet aklirik.
The Colocation of Magnetic Reconnection and Current Disruption in Jovian Middle Magnetosphere
Authors: Pan Dong-Xiao , Yao Zhong-Hua , Guo Rui-Long , Arridge Christopher S. , Ray Licia C. , Zhao Yong , Clark George , Rae I. Jonathan , Lui Anthony T. Y. , Zhang Bin-Zheng , Wei Yong , Zhou Xu-Zhi , Fu Hui-Shan , Connerney John E. P. , Bolton Scott J. 
Published: July 2024

Abstract
Magnetic reconnection and current disruption are two key processes in driving energy conversion and dissipation in planetary magnetospheres. At the Earth, the two processes usually occur at different locations: the current disruption process occurs more frequently in the near-Earth magnetotail ∼10 R
E, while the magnetotail reconnection process is expected to take place in the more distant region where the current sheet is thinner. Occasionally, under very intense solar wind perturbations, reconnection could be located closer to the Earth where current disruption processes usually operate. But it is unclear what the situation is at giant planets, in which the plasma environment is very different from the Earth. In this study, we investigate a middle-Jupiter reconnection event at ∼43 R
J. During the event, the inferred integrated cross-field currents were substantially reduced, which we argue is a signature of current disruption. In this case, we suggest that magnetic reconnection could be colocated with a current disruption process in the Jovian magnetosphere, which is roughly analogous to the situation in the extremely perturbed Earth’s magnetosphere.
Determination of the Abundance of Mercury from the Hg ii Line at 5677.10 Å in Late B-type Stars. IV. HD 149121 (28 Her) and HD 178065
Authors: Monier Richard 
Published: July 2024

Abstract
The weak line of Hg ii located at 5677.10 Å is used to measure the mercury abundance in two HgMn stars, HD 149121 (28 Her) and HD 178065. This line is detected at 3σ above the noise in the adjacent continuum in both stars. The synthesis of this line confirms a large overabundance of mercury, about +4.57 dex in HD 149121, and +3.70 dex in HD 178065, which is less than the excesses derived from the 3983.93 Å line in earlier studies. The presence of previously reported weak emission lines of Ti ii at 6106.50 Å and of Cr ii at 6158.62 and 6182.30 Å in the spectrum of HD 178065 is confirmed. The synthesis of other lines close to the Hg ii line yields estimates of the abundance deficiencies or excesses relative to solar abundances. Oxygen has a solar abundance (0.00 dex), silicon is deficient (−0.48 dex), iron also (−0.22 dex) and chromium is overabundant in HD 178065.
Analysis of Gaia DR3 Data of Selected High Galactic Latitude Hα Emission Stars
Authors: Parthasarathy Mudumba 
Published: July 2024

Abstract
Gaia DR3 data of 52 high galactic latitude Hα emission stars selected from the paper of Stephenson are analyzed. Ten new variable stars and eight new high velocity stars have been found. Details of six post-AGB stars and several other interesting stars are discussed. Many of the stars presented in this paper have Gaia DR3 light curves and spectra. A detailed study of these 52 stars is needed to derive their chemical composition and to further understand their binarity, circumstellar matter and evolutionary status. The astrophysical parameters from the Gaia DR3 data reveal several hot (OBA) and several F and G-type stars in this sample. Some of them are metal-poor stars.
Récit clinique : Raphaël dans le tourbillon de la vie
Authors: Bague Karine 
Published: July 2024

Au travers de l’histoire de Raphaël, nous montrons comment le travail clinique sur le lien entre un enfant placé et ses parents va se constituer et se consolider dans le cadre du dispositif des visites médiatisées, malgré les « orages », en s’inscrivant sur une temporalité nécessairement longue et en s’appuyant sur une relation transférentielle solide.
Existe-t-il une clinique rapide ?
Authors: Goursaud Florent 
Published: July 2024

Vitesse et progrès appartiennent à notre idéal de société depuis plusieurs décennies. Progressivement traduits en exigence de rapidité et d’efficacité dans les structures de soin, ils aboutissent à la création de dispositifs visant à faire bien en faisant vite. À partir d’une expérience au sein d’un « point écoute », le propos explore comment les cliniciens parviennent, en dépit de directives institutionnelles contraires à la logique du soin, à aménager un espace-temps qui permette aux patients de trouver une voie d’expression de leurs difficultés, tenant compte de la temporalité aléatoire des processus psychiques.
Giuseppe Maffei : anomalie ou articulation d’une pensée jungienne italienne ?
Authors: Carrara Stefano 
Published: July 2024

L’auteur expose la pensée de Giuseppe Maffei, psychanalyste jungien disparu depuis peu qui, avec ses écrits et son activité de formateur, de superviseur et de créateur de liens et d’échanges culturels, a contribué d’une manière significative au développement de la psychologie analytique en Italie. Le cadre est constitué par le contexte de l’histoire et des particularités du mouvement jungien italien, avec en arrière-plan les rapports entre la psychologie analytique et la psychanalyse à l’enseigne du pluralisme présent dans les conceptions de Jung. La lecture de Jung de la part de Maffei était fortement enracinée dans la clinique, à partir de celle des psychoses, mais privée de toute approche de type « scolaire » ou hypostasiante ; chez lui, le dialogue avec la psychanalyse freudienne et postfreudienne était constant, sans jamais par ailleurs s’aligner sur elle. Tout « savoir » avait pour finalité chez lui la rencontre avec la réalité psychique de l’autre, et cela d’une manière profondément jungienne.
Entre la recherche d’un idéal et la réalité de la rencontre avec un sujet
Authors: Le Berre Rozenn 
Published: July 2024

Nous interrogerons ici les enjeux éthiques et philosophiques d’un dialogue entre idéal et réalité dans le contexte des soins, en se concentrant en particulier sur le moment de la rencontre. À quelles conditions la rencontre intersubjective peut-elle survenir ? L’hypothèse que nous soutiendrons est que cette rencontre entre des sujets au cœur de la relation soignante est conditionnée par une dynamique complexe dont la fonction de l’idéal est l’enjeu.
Intérim : troubles dans la prévention
Authors: Barlet Blandine , Barnier Louis-Marie , Mascova Elena , Mias Arnaud , Pillon Jean-Marie 
Published: July 2024

La santé au travail des salariés intérimaires fait l’objet d’un suivi particulier, le problème de leur sur-accidentalité étant régulièrement mis à l’agenda. Pourtant, ce constat dissimule les lacunes dans l’objectivation et la prise en charge des expositions professionnelles des intérimaires. Il s’agit moins d’une ignorance que de dispositifs de suivi qui peinent à déclencher et à équiper l’action de prévention. L’analyse porte sur trois dispositifs institués de suivi des risques professionnels : l’enregistrement administratif des accidents du travail et des maladies professionnelles par la Caisse nationale de l’assurance maladie des travailleurs salariés (Cnam-TS), le suivi de l’état de santé des intérimaires par les services de santé au travail et l’évaluation et la prévention des risques organisées par les entreprises de travail temporaire. Pour chacun de ces dispositifs, sont analysés les initiatives, les efforts et les arguments déployés par celles et ceux qui sont chargé·es de ces questions et qui se trouvent ainsi placé·es en difficulté pour agir.
Cohomological $\chi$-independence for Higgs bundles and Gopakumar–Vafa invariants
Authors: Kinjo Tasuki , Koseki Naoki 
Published: July 2024

The aim of this paper is two-fold. Firstly, we prove Toda’s

\chi

-independence conjecture for Gopakumar–Vafa invariants of arbitrary local curves. Secondly, following Davison’s work, we introduce the BPS cohomology for moduli spaces of Higgs bundles of rank

r

and Euler characteristic

\chi

which are not necessary coprime, and show that it does not depend on

\chi

. This result extends the Hausel–Thaddeus conjecture on the

\chi

-independence of E-polynomials proved by Mellit, Groechenig–Wyss–Ziegler and Yu in two ways: We obtain an isomorphism of mixed Hodge modules on the Hitchin base rather than an equality of E-polynomials, and we do not need the coprime assumption. The proof of these results is based on a description of the moduli stack of one-dimensional coherent sheaves on a local curve as a global critical locus which is obtained in the companion paper by the first author and Naruki Masuda.
Network pharmacology- and molecular docking-based exploration of the molecular mechanism underlying Jianpi Yiwei Recipe treatment of gastric cancer
Authors: Chen Peng , Wu Huan-Yu 
Published: July 2024

BACKGROUND
Traditional Chinese medicine (TCM) is widely used as an important complementary and alternative healthcare system for cancer treatment in Asian countries. Network pharmacology, which utilizes various database platforms and computer software to study the interactions between complex drug components in vivo, is particularly useful for studying the pharmacodynamic mechanisms of multi-pathway and multi-target Chinese medicines.
AIM
To explore the potential targets and function of Jianpi Yiwei Recipe treatment of gastric cancer (GC) through network pharmacology and molecular docking.
METHODS
Data on the components of Jianpi Yiwei Recipe (Radix Astragali, Radix Codonopsis, Agrimonia eupatoria , Atractylodes macrocephala Koidz., Poria cocos , stir-baked rhizoma dioscoreae, Amomum villosum Lour., fried Fructus Aurantii, pericarpium citri reticulatae, Rhizoma Pinelliae Preparata, and Radix Glycyrrhizae Preparata) were collected and screened by using the TCM systems pharmacology database and analysis platform (TCMSP). Then the targets of these compounds were predicted. GC-related targets were screened using the GeneCards database. Venn diagram was used to identify common targets. An active ingredient-core target interaction network and a protein-protein interaction (PPI) network were built. Moreover, we performed gene ontology (GO) functional annotation and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses on the core targets and validated them by molecular docking.
RESULTS
TCMSP screening revealed 11 active components and 184 targets, whereas GeneCards found 10118 disease-related targets, with 180 shared targets between them. Topology analysis of the PPI network identified 38 targets, including ATK1, TP53, and tumor necrosis factor, as key targets for the treatment of GC by Jianpi Yiwei Recipe. Quercetin, naringenin, luteolin, etc. , may be the main active components of Jianpi Yiwei Recipe. GO enrichment analysis identified 2809, 1218, and 553 functions related to biological process, molecular function, and cellular component, respectively. KEGG pathway enrichment analysis revealed 167 related pathways, mainly involved in cancer, endocrine resistance, and AGE-RAGE signaling in diabetic complication. Validation with molecular docking analysis showed docking of key active components with core targets.
CONCLUSION
Jianpi Yiwei Recipe plays a therapeutic role in GC through multiple components, targets, and pathways. These findings form a basis for follow-up exploration of Jianpi Yiwei Recipe in the treatment of GC.
Integrated single-cell and bulk RNA sequencing revealed an epigenetic signature predicts prognosis and tumor microenvironment colorectal cancer heterogeneity
Authors: Liu Han-Xuan , Feng Jie , Jiang Jing-Jing , Shen Wan-Jun , Zheng Yu , Liu Gang , Gao Xiang-Yang 
Published: July 2024

BACKGROUND
Colorectal cancer (CRC) prognosis prediction is currently a major challenge. Epigenetic regulation has been widely reported for its role in cancer development.
AIM
To construct a robust prognostic signature, we used developed and validated across datasets.
METHODS
After constructing the signature, the prognostic value of the signature was evaluated in the TCGA cohort and six independent datasets (GSE17526, GSE17537, GSE33113, GSE37892, GSE39048 and GSE39582). The clinical, genomic and transcriptomic features related to the signature were identified. The correlations of the signature score with immune cell infiltration and cell-cell interactions were analyzed. The correlations between the signature score and the sensitivity to different drugs were also predicted.
RESULTS
In the TCGA cohort, patients in the low-risk group according to the signature score had longer survival than those in the high-risk group, and this finding was validated in the validation datasets. The signature was a prognostic factor independent of age and sex and was correlated with stage and PD-1 /PD-L1 expression. Area under the receiving operating characteristic curve was 0.72. Genomic association analyses revealed that samples from high-risk patients exhibited chromosomal instability. Transcriptomic analyses revealed that the signature score was significantly associated with multiple cellular pathways. Bulk RNA-seq and single-cell sequencing data revealed that the signature reflected differences in infiltrating immune cell-tumor cell interactions, especially for macrophages. The signature also predicted the putative drug sensitivity of CRC samples.
CONCLUSION
The signature is a valuable biomarker for predicting CRC prognosis and reflects multiple features of CRC, especially macrophage infiltration in the microenvironment.
Water Treatment Practices and Misperceived Social Norms among Women Living with Young Children in Rural Uganda
Authors: Perkins Jessica M. , Kakuhikire Bernard , Baguma Charles , Meadows Meredith , Abayateye Raphael , Rasmussen Justin D. , Satinsky Emily N. , Gumisiriza Patrick , Kananura Justus , Namara Elizabeth B. , Bangsberg David R. , Tsai Alexander C. 
Published: July 2024

ABSTRACT.
Access to water safe for consumption is critical for health and well-being, yet substantial structural barriers often necessitate household action to make water safer. Social norms about water treatment practices are understudied as a driver of personal water treatment practice. This study assesses reported and perceived water treatment practices among women in a rural, water insecure setting. We used cross-sectional data from a population-based study of women living with children under 5 years old across eight villages in southwest Uganda. Participants reported their typical household water treatment practices and what they perceived to be the common practices among most other women with young children in their own village. Modified multivariable Poisson regression models estimated the association between individual behavior and perceptions. Of 274 participants (78% response rate), 221 (81%) reported boiling water and 228 (83%) reported taking at least one action to make water safer. However, 135 (49%) misperceived most women with young children in their village not to boil their water, and 119 (43%) misperceived most to take no action. Participants who misperceived these norms were less likely to practice safe water treatment (e.g., for boiling water, adjusted relative risk = 0.80; 95% CI 0.69–0.92, P = 0.002), adjusting for other factors. Future research should assess whether making actual descriptive norms about local water treatment practices visible and salient (e.g., with messages such as “most women in this village boil their drinking water”) corrects misperceived norms and increases safe water treatment practices by some and supports consistent safe practices by others.