bluuebunny/crossref_metadata_2025_split huggingface dataset:
The swash of solitary waves on a plane beach: flow evolution, bed shear stress and run-up
Authors: Pujara Nimish , Liu Philip L.-F. , Yeh Harry 
Published: August 2015

The swash of solitary waves on a plane beach is studied using large-scale experiments. Ten wave cases are examined which range from non-breaking waves to plunging breakers. The focus of this study is on the influence of breaker type on flow evolution, spatiotemporal variations of bed shear stresses and run-up. Measurements are made of the local water depths, flow velocities and bed shear stresses (using a shear plate sensor) at various locations in the swash zone. The bed shear stress is significant near the tip of the swash during uprush and in the shallow flow during the later stages of downrush. In between, the flow evolution is dominated by gravity and follows an explicit solution to the nonlinear shallow water equations, i.e. the flow due to a dam break on a slope. The controlling scale of the flow evolution is the initial velocity of the shoreline immediately following waveform collapse, which can be predicted by measurements of wave height prior to breaking, but also shows an additional dependence on breaker type. The maximum onshore-directed bed shear stress increases significantly onshore of the stillwater shoreline for non-breaking waves and onshore of the waveform collapse point for breaking waves. A new normalization for the bed shear stress which uses the initial shoreline velocity is presented. Under this normalization, the variation of the maximum magnitudes of the bed shear stress with distance along the beach, which is normalized using the run-up, follows the same trend for different breaker types. For the uprush, the maximum dimensionless bed shear stress is approximately 0.01, whereas for the downrush, it is approximately 0.002.
Fluid intelligence and executive functioning more alike than different?
Authors: van Aken Loes , Kessels Roy P.C. , Wingbermühle Ellen , van der Veld William M. , Egger Jos I.M. 
Published: August 2015

ObjectiveFluid intelligence (Gf) has been related to executive functioning (EF) in previous studies, and it is also known to be correlated with crystallized intelligence (Gc). The present study includes representative measures of Gf, Gc, and EF frequently used in clinical practice to examine this Gf–EF relation. It is hypothesised that the Gf–EF relation is higher than the Gc–EF relation, and that working memory in particular (as a measure of EF) shows a high contribution to this relation.MethodConfirmatory factor analysis was performed on a mixed neuropsychiatric and non-clinical sample consisting of 188 participants, using the Kaufman Adolescent and Adult Intelligence Test, and three executive tasks of the Cambridge Neuropsychological Test Automated Battery, covering working memory, planning skills, and set shifting.ResultsThe model fitted the data well [χ2(24)=35.25, p=0.07, RMSEA=0.050]. A very high correlation between Gf and EF was found (0.91), with working memory being the most profound indicator. A moderate to high correlation between Gc and EF was present. Current results are consistent with findings of a strong relation between Gf and working memory.ConclusionGf and EF are highly correlated. Gf dysfunction in neuropsychiatric patients warrants further EF examination and vice versa. It is discussed that results confirm the need to distinguish between specific versus general fluid/executive functioning, the latter being more involved when task complexity and novelty increase. This distinction can provide a more refined differential diagnosis and improve neuropsychiatric treatment indication.
Food insecurity and malnutrition in Chinese elementary school students
Authors: Shen Xiuhua , Gao Xiang , Tang Wenjing , Mao Xuanxia , Huang Jingyan , Cai Wei 
Published: August 2015

AbstractIt has been shown that food insecurity is associated with poor diet quality and unfavourable health outcomes. However, little is known about the potential effects of food insecurity on the overall malnutrition status among children. In this study, we investigated the prevalence of food insecurity among 1583 elementary school students, aged 6–14 years, living in Chinese rural areas and examined its association with four malnutrition signs, including rickets sequelae, anaemia, stunting and wasting. Information on food security was collected via questionnaires. Rickets sequelae were assessed by an experienced paediatrician during the interview. Anaemia was determined by the WHO Hb thresholds adjusted by the local altitude. Weight and height were measured during the interview. Stunting and wasting were then evaluated according to WHO child growth standards (2007). We examined the association between food insecurity and the number of malnutrition signs (total number=4), and the likelihood of having severe malnutrition (presence of 3+ signs), after adjusting for potential confounders, such as age, social-economic status and dietary intakes. During the previous 12 months, the overall prevalence of food insecurity was 6·1 % in the entire studied population and 16·3 % in participants with severe malnutrition. Participants with food insecurity had a slightly higher number of malnutrition signs (1·14v.0·96;P=0·043) relative to those who were food secure, after adjusting for potential confounders. Food insecurity was also associated with increased likelihood of having severe malnutrition (adjusted OR 3·08; 95 % CI 1·47, 6·46;P=0·003). In conclusion, food insecurity is significantly associated with malnutrition among Chinese children in this community.
Fibre intake and incident colorectal cancer depending on fibre source, sex, tumour location and Tumour, Node, Metastasis stage
Authors: Vulcan Alexandra , Brändstedt Jenny , Manjer Jonas , Jirström Karin , Ohlsson Bodil , Ericson Ulrika 
Published: August 2015

AbstractStudies on fibre intake and incident colorectal cancer (CRC) indicate inverse associations. Differences by tumour stage have not been examined. We examined associations between fibre intake and its sources, and incidental CRC. Separate analyses were carried out on the basis of sex, tumour location and the Tumour, Node, Metastasis (TNM) classification. The Malmö Diet and Cancer Study is a population-based cohort study, including individuals aged 45–74 years. Dietary data were collected through a modified diet history method. The TNM classification was obtained from pathology/clinical records and re-evaluated. Among 27 931 individuals (60 % women), we found 728 incident CRC cases during 428 924 person-years of follow-up. Fibre intake was inversely associated with CRC risk (Ptrend=0·026). Concerning colon cancer, we observed borderline interaction between fibre intake and sex (P=0·052) and significant protective association restricted to women (Ptrend=0·013). Intake of fruits and berries was inversely associated with colon cancer in women (Ptrend=0·022). We also observed significant interactions between intakes of fibre (P=0·048) and vegetables (P=0·039) and sex on rectal cancer, but no significant associations were seen between intake of fibre, or its sources, in either of the sexes. Except for inverse associations between intake of fibre-rich cereal products and N0- and M0-tumours, we did not observe significant associations with different TNM stages. Our findings suggest different associations between fibre intake and CRC depending on sex, tumour site and fibre source. High fibre intake, especially from fruits and berries, may, above all, prevent tumour development in the colon in women. No clear differences by TNM classification were detected.
Molecular study of Stenoponia tripectinata tripectinata (Siphonaptera: Ctenophthalmidae: Stenoponiinae) from the Canary Islands: taxonomy and phylogeny
Authors: Zurita A. , Callejón R. , De Rojas M. , Gómez López M.S. , Cutillas C. 
Published: August 2015

AbstractIn the present work, we carried out a comparative molecular study of Stenoponia tripectinata tripectinata isolated from Mus musculus from the Canary Islands, Spain. The Internal Transcribed Spacers 1 and 2 (ITS1, ITS2) and 18S ribosomal RNA partial gene and cytochrome c-oxidase 1 (cox1) mitochondrial DNA partial gene sequences of this subspecies were determined to clarify the taxonomic status of this subspecies and to assess inter-population variation and inter-specific sequence differences. In addition, we have carried out a comparative phylogenetic study with other species of fleas using Bayesian, Maximum Parsimony, Maximum Likelihood and Neighbor-Joining analysis. A geographical signal was detected between the cox1 partial gene sequences of S. t. tripectinata isolated from M. musculus from different islands and those isolated from Apodemus sylvaticus from the Iberian Peninsula. Our results assess the monophyletic origin of Stenoponiinae and a different genetic lineage from Ctenophthalmidae. Thus, the elevation of subfamily Stenoponiinae to family level (Stenoponiidae) is suggested.
Impacts of a newly identified behaviour-altering trematode on its host amphipod: from the level of gene expression to population
Authors: GULER YASMIN , SHORT STEPHEN , GREEN ETXABE AMAIA , SHERHOD CHRISTOPHER M. , KILLE PETER , FORD ALEX T. 
Published: August 2015

SUMMARYChanges to host behaviour induced by some trematode species, as a means of increased trophic transmission, represents one of the seminal examples of host manipulation by a parasite. The amphipodEchinogammarus marinus (Leach, 1815) is infected with a previously undescribed parasite, with infected individuals displaying positive phototaxic and negative geotaxic behaviour. This study reveals that the unknown parasite encysts in the brain, nerve cord and the body cavity ofE. marinus, and belongs to the Microphallidae family. An 18 month population study revealed that host abundance significantly and negatively correlated with parasite prevalence. Investigation of the trematode's influence at the transcriptomic level revealed genes with putative neurological functions, such as serotonin receptor 1A, an inebriated-like neurotransmitter, tryptophan hydroxylase and amino acid decarboxylase, present consistent altered expression in infected animals. Therefore, this study provides one of the first transcriptomic insights into the neuronal gene pathways altered in amphipods infected with a trematode parasite associated with changes to its host's behaviour and population structure.
Fitness responses to co-infestation in fleas exploiting rodent hosts
Authors: KHOKHLOVA IRINA S. , DLUGOSZ ELIZABETH M. , KRASNOV BORIS R. 
Published: August 2015

SUMMARYTo understand mechanisms behind positive interspecific co-occurrences in flea infracommunities, we asked whether co-infestation results in an increase of flea fitness (quantity and/or quality of the offspring). We studied reproductive performance of Xenopsylla ramesis and Parapulex chephrenis when they exploited their characteristic host (Meriones crassus and Acomys cahirinus, respectively) either alone or together with another species. We used egg production, the number of new imagoes, pre-imaginal survival and egg size as fitness-related variables and predicted that fitness will be higher in fleas feeding in mixed- than in single-species groups. In both fleas, mean number of eggs produced per female flea did not depend on experimental treatment. No effect of single- vs mixed-species infestation on the mean number of new imagoes per female and the number of emerged imagoes per egg was found for X. ramesis, whereas both these numbers were higher in mixed- than in single-species groups for P. chephrenis. X. ramesis produced eggs of similar size independently of treatment, whereas eggs produced by P. chephrenis in mixed-species groups were significantly larger than eggs produced in single-species groups. We conclude that an increase in reproductive performance as a response to co-infestation may be one of the mechanisms behind aggregative structure of flea infracommunities. However, this response may vary among flea species.
Acceptance and commitment group therapy (ACT-G) for health anxiety: a randomized controlled trial
Authors: Eilenberg T. , Fink P. , Jensen J. S. , Rief W. , Frostholm L. 
Published: August 2015

Background.Severe health anxiety is frequent and costly, yet rarely diagnosed or treated. Earlier treatment studies show problems with recruitment, dropout and recovery. In the current study, the authors aimed to test the effect of acceptance and commitment group therapy (ACT-G) compared to waitlist in patients with severe health anxiety.Method.During March 2010 to April 2012, 126 consecutively referred patients meeting research criteria for severe health anxiety were block-randomized (1:1) to ACT-G or a 10 months’ waitlist (Clinicaltrials.gov, no. NCT01158430). Patients allocated to ACT-G were treated in seven groups of nine patients between December 2010 and October 2012 and received nine weekly 3-h group sessions and a booster session consisting of ACT techniques. The primary outcome was decideda priorias the mean change in self-reported illness worry on the Whiteley-7 Index (WI) from baseline to 10 months’ follow-up. Secondary outcomes were improvement in emotional distress and health-related quality of life at 10 months’ follow-up.Results.Intention-to-treat analysis showed a statistically significant mean difference of 20.5 points [95% confidence interval (CI) 11.7–29·4,p< 0.001] on the WI between the groups at 10 months, and the between-group effect sizes were large (Cohen'sd= 0.89, 95% CI 0.50–1.29). The number needed to treat was 2.4 (95% CI 1.4–3.4,p< 0.001). Diagnosis and treatment were well accepted by the patients.Conclusions.ACT-G seems feasible, acceptable and effective in treating severe health anxiety.
Non-traditional investments: key considerations for insurers
Authors: Mee G. 
Published: August 2015

AbstractLife insurers have historically relied upon investment markets as a key source of profit and crucially have been able to do this while embarking on relatively “vanilla” investment strategies. In the current low-yield environment, broadening their investment horizons is critical to maintaining profitability. This paper summarises some relevant external literature and the working party’s own research in understanding the potential benefits and pitfalls for insurers seeking to invest in non-traditional assets. The objective of this paper is to help educate and promote understanding by all (the many) relevant parties. In doing so, we hope to help organisations to achieve some further economic success for the ultimate benefit of society. Although this paper has primarily been written from the perspective of a life insurer, we hope it will be of interest to a much wider audience. Many of the asset classes considered here are relevant to general insurers, pension funds and the wider capital markets. It is very important to note that this paper does not contain investment advice and the analysis represents the views of the individuals and the working party and not the companies which they represent or the Profession. This paper does not make any comment as to the suitability (or otherwise) of specific investments for particular investors.
Monte Carlo calculations of an Elekta Precise SL-25 photon beam model
Authors: Padilla-Cabal Fátima , Pérez-Liva Mailyn , Lara Elier , Alfonso Rodolfo , Lopez-Pino Neivy 
Published: August 2015

AbstractBackgroundMonte Carlo (MC) simulations have been used extensively for benchmarking photon dose calculations in modern radiotherapy using linear accelerators (linacs). Moreover, a major barrier to widespread clinical implementation of MC dose calculation is the difficulty in characterising the radiation source using data reported from manufacturers.PurposeThis work aims to develop a generalised full MC histogram source model of an Elekta Precise SL-25 linac (electron exit window, target, flattening filter, monitor chambers and collimators) for 6 MV photon beams used in standard therapies. The inclusion of many different probability processes such as scatter, nuclear reactions, decay, capture cross-sections and more led to more realistic dose calculations in treatment planning and quality assurance.Materials and methodsTwo different codes, MCNPX 2·6 and EGSr-BEAM, were used for the calculation of particle transport, first in the geometry of the internal/external accelerator source, and then followed by tracking the transport and energy deposition in phantom-equivalent tissues. A full phase space file was scored directly above the upper multilayer collimator’s jaws to derive the beam characteristics such as planar fluence, angular distribution and energy spectrum. To check the quality of the generated photon beam, its depth dose curves and cross-beam profiles were calculated and compared with measured data.ResultsIn-field dose distributions calculated using the accelerator models were tuned to match measurement data with preliminary calculations performed using the accelerator information provided by the manufacturer. Field sizes of 3×3, 5×5, 10×10, 15×15 and 20×20 cm2were analysed. Local differences between calculated and measured curve doses beneath 2% were obtained for all the studied field sizes. Higher discrepancies were obtained in the air–water interface, where measurements of dose distributions with the ionisation chamber need to be shifted for the effective point of measurement.ConclusionThe agreements between MC-calculated and measured dose distributions were excellent for both codes, showing the strength and stability of the proposed model. Beam reconstruction methods as direct input to dose-calculation codes using the recorded histograms can be implemented for more accurate patient dose estimation.
The Impact of Religion on Voting For Female Congressional Candidates
Authors: Setzler Mark , Yanus Alixandra B. 
Published: August 2015

AbstractResearch shows that areas with high levels of aggregate religiosity are less likely to elect female candidates to national, state, and local offices. These studies, however, do not determine the causal mechanisms underlying this relationship. In the present analysis, we seek to examine what role, if any, religious exposure and tradition play in determining individuals’ general election vote choices in mixed-gender contests. To explore this relationship, we use data from the 2010 and 2012 Cooperative Congressional Election Studies. We find some evidence of a relationship between religious beliefs and voting for female congressional candidates; when compared to secular voters, evangelical Protestants and Catholics are more likely to vote for Republican women and less likely to support Democratic women. Our results, however, also underscore partisan identities’ central role in shaping individual vote choice, regardless of a candidate's gender.
Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer’s disease pathology
Authors: Baruch Kuti , Rosenzweig Neta , Kertser Alexander , Deczkowska Aleksandra , Sharif Alaa Mohammad , Spinrad Amit , Tsitsou-Kampeli Afroditi , Sarel Ayelet , Cahalon Liora , Schwartz Michal 
Published: August 2015

AbstractAlzheimer’s disease (AD) is a neurodegenerative disorder in which chronic neuroinflammation contributes to disease escalation. Nevertheless, while immunosuppressive drugs have repeatedly failed in treating this disease, recruitment of myeloid cells to the CNS was shown to play a reparative role in animal models. Here we show, using the 5XFAD AD mouse model, that transient depletion of Foxp3+regulatory T cells (Tregs), or pharmacological inhibition of their activity, is followed by amyloid-β plaque clearance, mitigation of the neuroinflammatory response and reversal of cognitive decline. We further show that transient Treg depletion affects the brain’s choroid plexus, a selective gateway for immune cell trafficking to the CNS, and is associated with subsequent recruitment of immunoregulatory cells, including monocyte-derived macrophages and Tregs, to cerebral sites of plaque pathology. Our findings suggest targeting Treg-mediated systemic immunosuppression for treating AD.
Directing cell therapy to anatomic target sites in vivo with magnetic resonance targeting
Authors: Muthana Munitta , Kennerley Aneurin J. , Hughes Russell , Fagnano Ester , Richardson Jay , Paul Melanie , Murdoch Craig , Wright Fiona , Payne Christopher , Lythgoe Mark F. , Farrow Neil , Dobson Jon , Conner Joe , Wild Jim M. , Lewis Claire 
Published: August 2015

AbstractCell-based therapy exploits modified human cells to treat diseases but its targeted application in specific tissues, particularly those lying deep in the body where direct injection is not possible, has been problematic. Here we use a magnetic resonance imaging (MRI) system to direct macrophages carrying an oncolytic virus, Seprehvir, into primary and metastatic tumour sites in mice. To achieve this, we magnetically label macrophages with super-paramagnetic iron oxide nanoparticles and apply pulsed magnetic field gradients in the direction of the tumour sites. Magnetic resonance targeting guides macrophages from the bloodstream into tumours, resulting in increased tumour macrophage infiltration and reduction in tumour burden and metastasis. Our study indicates that clinical MRI scanners can not only track the location of magnetically labelled cells but also have the potential to steer them into one or more target tissues.
CRL4–DCAF1 ubiquitin E3 ligase directs protein phosphatase 2A degradation to control oocyte meiotic maturation
Authors: Yu Chao , Ji Shu-Yan , Sha Qian-Qian , Sun Qing-Yuan , Fan Heng-Yu 
Published: August 2015

AbstractOocyte meiosis is a specialized cell cycle that gives rise to fertilizable haploid gametes and is precisely controlled in various dimensions. We recently found that E3 ubiquitin ligase CRL4 is required for female fertility by regulating DNA hydroxymethylation to maintain oocyte survival and to promote zygotic genome reprogramming. However, not all phenotypes of CRL4-deleted oocytes could be explained by this mechanism. Here we show that CRL4 controls oocyte meiotic maturation by proteasomal degradation of protein phosphatase 2A scaffold subunit, PP2A-A. Oocyte-specific deletion of DDB1 or DCAF1 (also called VPRBP) results in delayed meiotic resumption and failure to complete meiosis I along with PP2A-A accumulation. DCAF1 directly binds to and results in the poly-ubiquitination of PP2A-A. Moreover, combined deletion of Ppp2r1a rescues the meiotic defects caused by DDB1/DCAF1 deficiency. These results provide in vivo evidence that CRL4-directed PP2A-A degradation is physiologically essential for regulating oocyte meiosis and female fertility.