bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal detection and early warning mechanism of power market transaction data: a practice and exploration
Authors: Gong Yuying , Cheng Xiaolei , Liu Yanhang , Xu Kai , Wudabala   
Published: August 2024

AbstractWith the rapid evolution of the electricity market and the significant surge in power transactions, anomalies in data could wield substantial influence and pose risks to market participants, regulatory bodies, and the overall market operation. This study addresses the voluminous nature of power trading data and the imperative for real-time processing by introducing an anomaly detection method based on the local outlier factor (LOF) algorithm to identify anomalous data points in the electricity market. Simultaneously, this research enhances the LOF algorithm by incorporating the closest distance to center (CDC) algorithm and leveraging the introduction of local reachability density based on k-nearest neighbors, termed as the CDCLOF-k model. The F1 score of the two-stage identification method generally surpasses that of the single-stage method, achieving optimal effectiveness even with smaller values of k, with minimal fluctuation as k varies. Simulation experiments demonstrate that the improved algorithm not only ensures the accuracy of outlier detection but also enhances its efficiency. Future endeavors may delve into more intricate trading anomaly scenarios to further enhance the performance and applicability of this algorithm.
Behavioral activity patterns but not hair cortisol concentrations explain steers’ transition-related stress in the first 6 wk in the feedlot
Authors: Mijar Sanjaya , van der Meer Frank , Hodder Abigail , Pajor Ed , Orsel Karin 
Published: August 2024

Abstract
Stress during the transition of beef steers from ranch to feedlot may depend on steer source and preconditioning. The interplay between physiological and behavioral patterns of preconditioned (PC) and auction-derived (AD) steers, particularly after commingling, is poorly understood. Our objective was to evaluate whether hair cortisol (HC) concentrations were related to the health and performance of PC and AD steers and study behavioral activities after commingling over 6 wk in a feedlot. Steers, sourced either from ranch (PC, n = 250) or local auction (AD, n = 250), were assigned into 1 of 5 pens, 100% PC (100PC); 75% PC 25% AD (75PC); 50% PC 50% AD (50PC); 25% PC 75% AD (25PC), and 100% AD (0PC), each pen containing 100 steers. Pen was the experimental unit and individual steers were the observational unit where physiological and behavioral changes were measured. The study subsampled 225 steers (PC = 113 and AD = 112) which were equipped with CowManager ear tags to record behaviors. On day 40, hair samples from each steer were collected by clipping hair close to the skin. Data were analyzed using multiple linear, logistic regression, or multilevel negative binomial regression models depending on the outcomes. There was no difference in HC concentrations (day 40) between PC and AD steers (P = 0.66), and no association with Bovine Respiratory Disease (BRD)-related morbidity (P = 0.08) or average daily gain (ADG) (P = 0.44). After adjusting for source and commingling effects, HC concentrations did not affect time spent eating (P = 0.83), ruminating (P = 0.20), active (P = 0.89), or non-active (P = 0.32). PC steers spent more time eating and ruminating over weeks 1 to 4 (P &lt; 0.01) and weeks 1 to 3, respectively (P &lt; 0.05), and more time being active over weeks 1 and 2 compared to AD steers (P &lt; 0.001), but less time being non-active than AD steers on weeks 1 to 3 (P &lt; 0.001). Steers in 100PC and 50PC pens spent more time eating than steers in 0PC (P &lt; 0.001), whereas steers in 25PC spent less time eating than steers in 0PC (P &lt; 0.001). Steers in 0PC spent the most time being not active (P &lt; 0.01). In conclusion, preconditioned steers spent more time eating, ruminating, and being active and less time being not active over the first 3 wk in the feedlot, regardless of commingling. The HC concentrations did not identify potentially lower stress related to ranch transfer and were neither associated with BRD-related morbidity nor ADG.
Phytopathological management through bacteriophages: enhancing food security amidst climate change
Authors: Ul Haq Ihtisham , Khan Mehtab , Khan Imran 
Published: August 2024

Abstract

The increasing global population and climate change pose significant challenges to agriculture, particularly in managing plant diseases caused by phytopathogens. Traditional methods, including chemical pesticides and antibiotics, have become less effective due to pathogen resistance and environmental concerns. Phage therapy emerges as a promising alternative, offering a sustainable and precise approach to controlling plant bacterial diseases without harming beneficial soil microorganisms. This review explores the potential of bacteriophages as biocontrol agents, highlighting their specificity, rapid multiplication, and minimal environmental impact. We discuss the historical context, current applications, and prospects of phage therapy in agriculture, emphasizing its role in enhancing crop yield and quality. Additionally, the paper examines the integration of phage therapy with modern agricultural practices and the development phage cocktails and genetically engineered phages to combat resistant pathogens. The findings suggest that phage therapy could revolutionize phytopathological management, contributing to global food security and sustainable agricultural practices.

One-Sentence Summary
The burden of plant diseases and phage-based phytopathological treatment.
Tiny silver bullets: silver nanoparticles are insecticidal to Culicoides sonorensis (Diptera: Ceratopogonidae) biting midge larvae
Authors: Osborne Cameron J , Norton Amie E , Whitworth R Jeff , Silver Kristopher S , Cohnstaedt Lee W 
Published: August 2024

Abstract
Insecticide formulations with safer environmental profiles and limited off-target effects are desirable to manage medical and veterinary pests. Silver nanoparticles are insecticidal against mosquitos, nonbiting midges, and other insects. The biting midge, Culicoides sonorensis Wirth and Jones, is a vector of agriculturally important pathogens in much of the United States, and this study aimed to examine the insecticidal properties of silver nanoparticles in larvae of this species. Mortality of third-instar larvae was assessed daily for 7 days after exposure to concentrations of silver nanoparticles, sorghum polymer particles, and hybrid silver–sorghum polymer particles. Both silver nanoparticles and silver–sorghum polymer particles were insecticidal, but sorghum polymer particles alone did not significantly contribute to larval mortality. Concentrations of 100 mg/liter of silver nanoparticles achieved &gt;50% mortality at day 7, and 200 mg/liter treatments achieved &gt;75% larval mortality within 24 h. The antimicrobial properties of silver nanoparticles were also examined, and culturable bacteria were recovered from larval-rearing media at 200 mg/liter but not at 400 mg/liter of silver nanoparticles. These data suggest that C. sonorensis larval mortality is primarily caused by silver nanoparticle toxicity and not by the reduction of bacteria (i.e., a larval food source). This work describes the first use of silver nanoparticles in C. sonorensis and shows the potential insecticide applications of these nanoparticles against this agricultural pest. The grain-polymer particles also successfully carried insecticidal silver nanoparticles, and their utility in loading diverse compounds could be a novel toxin delivery system for biting midges and similar pests.
Laparoscopic management of bowel perforation secondary to levonorgestrel-releasing intrauterine device migration: a case report and review of literature
Authors: Han Jeong Hee , Yu Eun Hee , Joo Jong Kil , Kim Min Ju , Choi Jung Bum , Jung Hyuk Jae , Jo Hong Jae , Lee Byoung Chul 
Published: August 2024

Abstract
Bowel perforation secondary to a levonorgestrel-releasing intrauterine device is exceptionally rare. We present the case of a woman who exhibited abnormal findings during a colonoscopy examination. Despite undergoing an intrauterine device (IUD) insertion procedure for contraception in 2000, attempts for its removal in 2007 were unsuccessful due to the inability to locate the IUD. In 2022, she presented with intermittent hematochezia and lower left abdominal pain. Subsequent colonoscopy and abdominal computed tomography confirmed the presence of the IUD penetrating the uterine wall and entering the colon. Laparoscopic anterior resection was performed, and the patient’s postoperative recovery was uneventful, indicating the viability of laparoscopic treatment as a valuable option.
Thermal imaging for monitoring the treatment of hemangioma in pediatric patient: case report
Authors: Guerrero Marco E , Lacouture Natalia A , Manzur Ayala Ricardo 
Published: August 2024

Abstract
Pediatric hemangiomas are benign vascular malformations or angiodysplasias characterized by the proliferation of endothelial cells in blood vessels. Their incidence is 4%–10% in children under 1 year of age, and they most frequently occur on the head and neck [1, 2]. In addition to causing facial deformities, facial hemangiomas can lead to both functional and aesthetic issues, often resulting in significant complications. These complications negatively impact the quality of life for patients and can also affect the psychological well-being and self-esteem of their families [3]. With the expected global smartphone penetration reaching 70% [4], this case report explores the use of smartphones integrated with thermographic cameras to monitor the involution of hemangiomas during sclerosing treatment. This approach represents a promising advancement in managing and assessing hemangioma treatment through accessible, real-time monitoring technology.
Revising non-monotonic theories with sufficient and necessary conditions: the case of Defeasible Logic
Authors: Olivieri Francesco , Cristani Matteo , Governatori Guido , Pasetto Luca , Rotolo Antonino , Scannapieco Simone , Tomazzoli Claudio , Chekole Workneh Tewabe 
Published: August 2024

Abstract
In the setting of Defeasible Logic, we deal with the problem of revising and contracting a non-monotonic theory while minimizing the number of rules to be removed from the theory itself. The process is based on the notions of a set of rules being necessary and sufficient in order to prove a claim. The substantial difference among classical and non-monotonic reasoning processes makes this issue significant in order to achieve the correct revision processes. We show that the process is however computationally hard, and can be solved in polynomial time on non-deterministic machines.
Rebound Hyperthermia in Exertional Heat Stroke
Authors: DeHan Preston J , Flores Shelley A , Rhodehouse Blair B , Kaplan Joseph J , DeGroot David W 
Published: August 2024

ABSTRACT
Exertional heat stroke (EHS) is a life-threatening condition requiring rapid reversal of hyperthermia to prevent poor health outcomes. Current treatment protocols aim for a cooling rate of 0.15 C/min using various modalities. This case report details a 22-year-old male who, despite initial successful cooling measures, experienced rebound hyperthermia, necessitating the use of endovascular cooling (EVC). The patient collapsed during a 19.3 km (12-mile) ruck march in Fort Moore, Georgia, with an initial core temperature of 41.6ºC. Conventional cooling methods, including ice sheets and chilled intravenous saline, adequately cooled the patient to target temperatures; however, discontinuation of cooling methods resulted in rebound hyperthermia. Endovascular cooling was eventually initiated, resulting in euthermia after 36 hours of continued use. During his hospital admission, the patient was evaluated thoroughly for underlying etiologies contributing to his rebound hyperthermia. This workup did not yield any concerning pathology, except for bilateral foot cellulitis noted on physical examination, which was subsequently managed with antibiotics. Despite initial complications, the patient recovered within 5 days and returned to duty after 2 months. Several case reports have been published regarding the use of EVC in the management of EHS. These reports, however, describe its use in initial management of EHS or in cases where hyperthermia was refractory to other conventional cooling methods. To our knowledge, this is the first report of its kind highlighting its successful implementation in rebound hyperthermia. Early recognition and initiation of cooling measures are critical in EHS cases. Future directions include developing EHS-specific EVC protocols for patients experiencing refractory or rebound hyperthermia.
The Clinical Impact of Time-restricted Eating on Cancer: A Systematic Review
Authors: Stringer Eleah J , Cloke Rob W G , Van der Meer Lindsay , Murphy Rachel A , Macpherson Nicol A , Lum Julian J 
Published: August 2024

AbstractContextIn the face of the growing global burden of cancer, there is increasing interest in dietary interventions to mitigate its impacts. Pre-clinical evidence suggests that time-restricted eating (TRE), a type of intermittent fasting, induces metabolic effects and alterations in the gut microbiome that may impede carcinogenesis. Research on TRE in cancer has progressed to human studies, but the evidence has yet to be synthesized.ObjectiveThe objective of this study was to systematically evaluate the clinical and/or metabolomic effects of TRE compared with ad libitum eating or alternative diets in people with cancer.Data SourcesOvid MEDLINE, Ovid Embase, CINAHL, Ovid Cochrane Central Register of Control Trials (CENTRAL), Web of Science Core Collection (ESCI, CPCI-SSH, CPCI-S), and SCOPUS were searched up to January 4, 2023, using the core concepts of “intermittent fasting” and “cancer.” Original study designs, protocols, and clinical trial registries were included.Data ExtractionAfter evaluating 13 900 results, 24 entries were included, consisting of 8 full articles, 2 abstracts, 1 published protocol and 13 trial registries. All data were extracted, compared, and critically analyzed.Data AnalysisThere was heterogeneity in the patient population (eg, in tumor sites), TRE regimens (eg, degree of restriction, duration), and clinical end points. A high rate (67–98%) of TRE adherence was observed, alongside improvements in quality of life. Four articles assessed cancer markers and found a reduction in tumor marker carcinoembryonic antigen, reduced rates of recurrence, and a sustained major molecular response, following TRE. Five articles demonstrated modified cancer risk factors, including beneficial effects on body mass index, adiposity, glucoregulation, and inflammation in as short a period as 8 weeks. None of the completed studies assessed the effect of TRE on the microbiome, but analysis of the microbiome is a planned outcome in 2 clinical trials.ConclusionsPreliminary findings suggest that TRE is feasible and acceptable by people with cancer, may have oncological benefits, and improves quality of life.RegistrationPROSPERO registration No. CRD42023386885.
AAV‐mouse DNase I sustains long‐term DNase I expression in vivo and suppresses breast cancer metastasis
Authors: Herre Melanie , Vemuri Kalyani , Cedervall Jessica , Nissl Stefanie , Saupe Falk , Micallef Jacob , Lindman Henrik , Maguire Casey A. , Tetz George , Tetz Victor , Olsson Anna‐Karin 
Published: August 2024

AbstractNeutrophil extracellular traps (NETs) have been implicated in the pathology of various inflammatory conditions. In cancer, NETs have been demonstrated to induce systemic inflammation, impair peripheral vessel and organ function and promote metastasis. Here we show that the plasma level of NETs is significantly higher in patients with metastatic breast cancer compared to those with local disease, or those that were considered cured at a 5‐year follow‐up, confirming NETs as interesting therapeutic targets in metastatic breast cancer. Administration of DNase I is one strategy to eliminate NETs but long‐term treatment requires repeated injections and species‐specific versions of the enzyme. To enhance administration and therapeutic efficacy, we have developed an adeno‐associated virus (AAV) vector system for delivery of murine DNase I and addressed its potential to counteract cancer‐associated pathology in the murine MMTV‐PyMT model for metastatic mammary carcinoma. The AAV vector is comprised of capsid KP1 and an expression cassette encoding hyperactive murine DNase I (AAV‐mDNase I) under the control of a liver‐specific promotor. This AAV‐mDNase I vector could support elevated expression and serum activity of murine DNase I over at least 8 months. Neutrophil Gelatinase‐Associated Lipocalin (NGAL), a biomarker for kidney hypoperfusion that is upregulated in urine from MMTV‐PyMT mice, was suppressed in mice receiving AAV‐mDNase I compared to an AAV‐null control group. Furthermore, the proportion of mice that developed lung metastasis was reduced in the AAV‐mDNase I group. Altogether, our data indicate that AAV‐mDNase I has the potential to reduce cancer‐associated impairment of renal function and development of metastasis. We conclude that AAV‐mDNase I could represent a promising therapeutic strategy in metastatic breast cancer.
Using Assigned Peer Discussants to Enhance Engagement and Feedback for Student Presentations
Authors: Sharpe Elizabeth Li , Teall Alice M. , King Tara Spalla 
Published: August 2024

Abstract
Nursing students are frequently assigned to provide case or topical presentations in class. They are often nervous about presenting, which can distract them from learning from peers. Faculty introduced the role of the assigned discussant to enhance engagement and enable peer feedback in real time. After students presented a brief elevator-pitch style speech, peer discussants were instructed to respond following specific prompts to reflect on key takeaways and remaining questions. Faculty coached students to demonstrate focused, active listening skills and to provide quality feedback using this teaching-learning innovation. Students were enthusiastic about providing and receiving immediate, constructive collegial peer support.
Idiopathic Fusarium Sclerouveitis: A Case Report
Authors: Shetty Akaanksh , Baeza Drew , Amescua Guillermo , Galor Anat 
Published: August 2024

Purpose:
To report a successfully managed case of idiopathic Fusarium sclerouveitis in a healthy patient with no identifiable risk factors.

Methods:
We describe a case of a 79-year-old man who presented with right-sided eye, facial, and head pain. Initial examination revealed temporal scleral thinning, inflammation, and anterior chamber cell/flare. Cultures were positive for Fusarium species.

Results:
The patient was treated with sub-Tenon amphotericin, intrascleral voriconazole, surgical debridement, Rose Bengal photodynamic therapy, systemic voriconazole and posaconazole, and topical natamycin. The infection resolved and the patient's visual acuity improved to 20/40.

Conclusions:
Fusarium sclerouveitis can occur without clear risk factors. This case highlights the importance of an aggressive, multimodal treatment approach for successful management.
A Modified 270 Degree Closure Technique to Address the Prominent or Locked-Out Premaxilla in Bilateral Cleft Palate Repair
Authors: Vargo James D. , Thurston Todd T. , Buchman Steven R. 
Published: August 2024

Summary:
The bilateral cleft deformity with a prominent or ‘locked-out’ premaxilla presents one of the most challenging repairs in cleft surgery. Despite its relative frequency, traditional hard palate repair techniques fail to fully address this deformity and expose surgeons to the risk of development of a large anterior fistula when flaps cannot approximate the premaxilla. This greatly increases morbidity for the patient and creates unnecessary challenges during fistula repair or alveolar cleft bone graft later in childhood. The 270° closure technique extends the nasal closure 270° around the premaxilla, continuing the hard palate repair through the alveolar clefts. This technique has been performed on 41 patients with mean follow up of 10.8 years. The repair was successful in 93% of patients with 3 patients developing palatal fistulae, all posterior to the 270° closure. The 270° cleft palate repair around the prominent premaxilla fills a void in the literature for managing the immense challenge of this deformity. When presurgical orthopedics are not a viable option, this approach can minimize the risk of large or complex fistula formation posterior to the premaxilla.
Optic Nerve Sheath Diameter on Computed Tomography Scans Reflects Elevated Intracranial Pressure in Patients with Craniosynostosis
Authors: Romeo Dominic J. , Sussman Jonathan H. , Massenburg Benjamin B. , Halverson Mark , Ng Jinggang J. , Wu Meagan , Liu Grant T. , Bartlett Scott P. , Taylor Jesse A. , Swanson Jordan W. 
Published: August 2024

Introduction:
Assessment for elevated intracranial pressure (ICP) helps guide interventional decision-making to treat craniosynostosis. However, non-invasive techniques for measuring ICP are limited. This study assesses whether optic nerve sheath diameter (ONSD) on low-dose computed tomography (CT) scans is associated with ICP in patients with craniosynostosis.

Methods:
Pediatric patients treated between 2014 and 2023 with craniosynostosis, intraoperative ICP measurements by direct subdural catheterization, and spectral domain-optical coherent tomography (SD-OCT) data were included. ONSD was retrospectively assessed on pre-operative CT scans by a masked neuroradiologist and compared to measures and proxies of ICP.

Results:
Among 132 patients included, median age was 6.9 years (IQR 4.7-9.5) and 41 (31.1%) had a syndromic diagnosis. Maximum ONSD (ONSDmax) was increased in patients with ICP≥15mmHg (6.1mm vs. 5.5mm, p<0.01) and ICP≥20mmHg (6.3mm vs. 5.6mm, p<0.01). Maximum (r=0.32, p<0.001), minimum (r=0.26, p=0.003), and average (r=0.29, p<0.001) ONSD correlated with direct ICP measurements. ONSD and SD-OCT measurements were also correlated (RNFLmax: r=0.21, p=0.04; RTmax: r=0.24, p=0.02). An ONSDmax threshold of 5.75mm demonstrated 65% sensitivity and 64% specificity for detecting ICP≥15mmHg on optimized receiver operating characteristic curve analysis. Multivariable logistic regression generated an algorithm incorporating ONSDmax and age to detect ICP≥20mmHg with 64% sensitivity and 80% specificity.

Conclusion:
Optic nerve sheath diameter measured in low-dose CT scans detects elevated intracranial pressure with moderate accuracy, and precision increases when patient age is taken into consideration. Given the ease of accessing CT scan data, this may be a helpful ICP proxy for clinical decision-making.