bluuebunny/crossref_metadata_2025_split huggingface dataset:
On the path to UHC, digital healthcare transformation with Karnataka’s online referral framework
Authors: Shastri Suresh G. , Sancheti Pooja , Ichini Sushil Kumar , Dayananda Gagana G. , Jayaprakash Murugesh , Sagar Spoorthy , Asif Mohamed , Devendiran Randeep 
Published: July 2024

Abstract
Background
Karnataka, a trailblazer in Universal Health Coverage (UHC) initiatives, has implemented various features under the Ayushman Bharat-PMJAY-Arogya Karnataka scheme to improve the access to health. This study provides a thorough exploration of Karnataka’s innovative Online Referral System (ORS) within the framework of achieving UHC.

Methods
The study analyses the performance of the ORS using cross-sectional data from June 2022 to November 2023, providing insights into the distribution of referrals, strategic purchasing from private healthcare providers, and the top medical procedures referred. The article delves into the unique features of Karnataka’s Online Referral System, implemented in 2019, which has streamlined the referral process and enhanced communication among healthcare providers.

Results
The findings underscore the positive impact of Karnataka’s ORS on healthcare efficiency, patient satisfaction, easy access to care and strategic purchasing from private healthcare providers. ORS demonstrates improved efficiency in referrals, mitigating the challenges associated with traditional manual process and is an important aspect in improving healthcare services. The system also provides insights on the specialities requiring more capacity building, the volume, completeness, and processing of referrals through the ORS.

Conclusion
Karnataka’s innovative ORS, presents a transformative solution for improving healthcare access, coordination, and outcomes, reinforcing Karnataka’s commitment to continuous innovation in healthcare delivery and progress towards Universal Health care. The system also offers valuable insights into specialties that require increased access, identifies gaps in the healthcare system, and outlines areas that need strengthening. The article concludes by advocating for the replication of Karnataka’s ORS model across India and suggests potential avenues for further research and improvement.
LongTR: genome-wide profiling of genetic variation at tandem repeats from long reads
Authors: Ziaei Jam Helyaneh , Zook Justin M. , Javadzadeh Sara , Park Jonghun , Sehgal Aarushi , Gymrek Melissa 
Published: July 2024

AbstractTandem repeats are frequent across the human genome, and variation in repeat length has been linked to a variety of traits. Recent improvements in long read sequencing technologies have the potential to greatly improve tandem repeat analysis, especially for long or complex repeats. Here, we introduce LongTR, which accurately genotypes tandem repeats from high-fidelity long reads available from both PacBio and Oxford Nanopore Technologies. LongTR is freely available at https://github.com/gymrek-lab/longtr and https://zenodo.org/doi/10.5281/zenodo.11403979.
Effects of proprioceptive training on sports performance: a systematic review
Authors: Yılmaz Osman , Soylu Yusuf , Erkmen Nurtekin , Kaplan Turgut , Batalik Ladislav 
Published: July 2024

Abstract
Background
Proprioception, the ability to sense the body’s position and movement, is essential for athletic performance and physical well-being. The literature highlights the importance of proprioceptive training in rehabilitation, sports performance, injury prevention, and motor function enhancement. Targeted training programs can improve balance, coordination, motor learning, and overall physical performance. This systematic review aimed to examine the effects of proprioceptive training methods on sports and athletic performance.

Methods
A comprehensive search was conducted using the Web of Science, PubMed, and Scopus databases, and a literature review was performed based on the PICO criteria outlined in the abstract and title.

Results
Following the search, 178 articles were identified using relevant keywords, of which 19 directly addressed sports performance and were included in this study. The findings revealed that proprioceptive training had a positive influence on various aspects of athletic performance, including physiological capacity, balance, explosive strength, speed, agility, postural stability, knee joint position sense, muscle activation, reduction of chronic joint instability, dribbling, passing, and technical ball-control skills.

Conclusions
These results indicate that proprioceptive training can be an effective strategy for experts and coaches to enhance athletes’ physical performance. Primarily, proprioceptive exercises should be used inside and outside the training sessions to enable athletes to interact more effectively with their bodies, reduce the risk of injury, and improve power transfer.
Unmasking an unusual presentation of Hodgkin’s lymphoma masquerading as ocular inflammation: a case report
Authors: Zein-El-Din Anna , Abdo Rami , Elbachti Amina , Boustani Gabriel , Salik Dany , Pourjavan Sayeh 
Published: July 2024

Abstract
Background
Hodgkin’s lymphoma (HL) is an extremely rare cause of ocular inflammation that is usually not considered in the typical workup of uveitis and other eye diseases. A few cases of ocular inflammation were reported previously showcasing HL with absence of typical symptoms of HL at presentation. Acknowledging the potential ocular inflammation associated with HL can prompt ophthalmologists to broaden their diagnostic approach and collaborate with internal medicine departments to investigate this rare yet significant etiology.

Case presentation
A 17-year-old Caucasian woman presenting unilateral panuveitis was later diagnosed with HL. The ocular findings were non-necrotizing scleritis, anterior uveitis, vitritis, white/yellowish chorioretinal lesions, papillitis and vasculitis. A left supra-clavicular lymph node biopsy confirmed the diagnosis of nodular sclerosing Hodgkin’s lymphoma stage IIB. Other causes of uveitis were excluded. Chemotherapy led to remission of the disease and the ocular lesions became quiescent with persistent pigmented chorioretinal scars.

Conclusions
Hodgkin's lymphoma should be considered in the differential diagnosis of diseases that can occasionally be revealed by unilateral ocular inflammation. A comprehensive, multidisciplinary approach is key to properly assessing such cases.
Embedding community and public voices in co-created solutions to mitigate antimicrobial resistance (AMR) in Thailand using the ‘Responsive Dialogues’ public engagement framework
Authors: Poomchaichote Tassawan , Kiatying-Angsulee Niyada , Boonthaworn Kanpong , Naemiratch Bhensri , Ruangkajorn Supanat , Prapharsavat Ravikanya , Thirapantu Chaiwat , Sukrung Karnjariya , Limmathurotsakul Direk , Osterrieder Anne , Cheah Phaik Yeong 
Published: July 2024

AbstractThe use of antimicrobials in Thailand has been reported as one of the highest in the world in human and animal sectors. Our engagement project aimed to improve our understanding of the issue of antimicrobial use and antimicrobial resistance (AMR) among adult Thai communities, and co-create locally relevant solutions to AMR, especially those focusing on raising awareness to improve related policies in Thailand.We conducted a series of online and in-person ‘conversations’ according to Wellcome’s ‘Responsive Dialogues’ engagement approach, designed to bring together different voices to understand complex AMR problems and find potential solutions. This approach enabled key AMR stakeholders and policy makers to hear directly from communities and members of the public, and vice versa. Conversations events took place between 25 November 2020 and 8 July 2022, and we engaged 179 AMR key stakeholders and members of the public across Thailand.The issues found were: there were quite a lot of misunderstandings around antimicrobials and AMR; participants felt that communications and engagement around antimicrobial resistance had limited reach and impact; asking for and taking antibiotics for self-limiting ailments is a social norm in Thailand; and there appeared to be a wide availability of cheap antimicrobials. To mitigate the spread of AMR, participants suggested that the messages around AMR should be tailored to the target audience, there should be more initiatives to increase general health literacy, there should be increased availability of AMR related information at the local level and there should be increased local leadership of AMR mitigation efforts.Trial registration Thaiclinicaltrials.org registration: TCTR20210528003 (28/05/2021).
Modifiable predictors of mental health literacy in the educational context: a systematic review and meta-analysis
Authors: Suwanwong Charin , Jansem Anchalee , Intarakamhang Ungsinun , Prasittichok Pitchada , Tuntivivat Sudarat , Chuenphittayavut Krittipat , Le Khuong , Lien Le Thi Mai 
Published: July 2024

AbstractMental health literacy is vital for well-being in educational settings, extending beyond academics to include social and emotional development. It empowers individuals, allowing them to recognize and address their mental health needs and provide essential support to their peers. Despite the acknowledged importance of modifiable factors, there is a noticeable research gap in those amenable to change through educational interventions. Thus, this systematic review aims to identify potentially modifiable predictors of mental health literacy in the educational context. A systematic search was conducted for quantitative studies published between 2019 and October 2023 using several databases following PRISMA guidelines. Studies needed to focus on potentially modifiable predictors of mental health literacy in the educational context. Study quality was assessed using the Appraisal tool for Cross-Sectional Studies (AXIS tool). In total, 3747 titles and abstracts were screened, 60 articles were assessed in full-text screening, and 21 were included in the review. Significant correlations between mental health literacy and modifiable predictors, including stigma toward professional help, self-efficacy, attitudes toward help-seeking, social support, positive psychological states, receiving mental health training, and psychological distress, were identified. By addressing these factors, educational institutions can cultivate community’s adept in mental health, fostering an environment marked by empathy, understanding, and proactive engagement in addressing mental health issues. The implications serve as a foundation for future research, policy development, and implementing of practical strategies to enhance mental health literacy in diverse educational settings.
Monodispersed mesoscopic star-shaped gold particles via silver-ion-assisted multi-directional growth for highly sensitive SERS-active substrates
Authors: Kim Sumin , Yoo Sunghoon , Nam Dong Hwan , Kim Hayoung , Hafner Jason H. , Lee Seunghyun 
Published: July 2024

AbstractSurface-enhanced Raman scattering (SERS) exploits localized surface plasmon resonances in metallic nanostructures to significantly amplify Raman signals and perform ultrasensitive analyses. A critical factor for SERS-based analysis systems is the formation of numerous electromagnetic hot spots within the nanostructures, which represent regions with highly concentrated fields emerging from excited localized surface plasmons. These intense hotspot fields can amplify the Raman signal by several orders of magnitude, facilitating analyte detection at extremely low concentrations and highly sensitive molecular identification at the single-nanoparticle level. In this study, mesoscopic star-shaped gold particles (gold mesostars) were synthesized using a three-step seed-mediated growth approach coupled with the addition of silver ions. Our study confirms the successful synthesis of gold mesostars with numerous sharp tips via the multi-directional growth effect induced by the underpotential deposition of silver adatoms (AgUPD) onto the gold surfaces. The AgUPD process affects the nanocrystal growth kinetics of the noble metal and its morphological evolution, thereby leading to intricate nanostructures with high-index facets and protruding tips or branches. Mesoscopic gold particles with a distinctive star-like morphology featuring multiple sharp projections from the central core were synthesized by exploiting this phenomenon. Sharp tips of the gold mesostars facilitate intense localized electromagnetic fields, which result in strong SERS enhancements at the single-particle level. Electromagnetic fields can be further enhanced by interparticle hot spots in addition to the intraparticle local field enhancements when arranged in multilayered arrays on substrates, rendering these arrays as highly efficient SERS-active substrates with improved sensitivity. Evaluation using Raman-tagged analytes revealed a higher SERS signal intensity compared to that of individual mesostars because of interparticle hot spots enhancements. These substrates enabled analyte detection at a concentration of 10− 9 M, demonstrating their remarkable sensitivity for trace analysis applications.
[68Ga]Ga‑PSMA‑617 PET-based radiomics model to identify candidates for active surveillance amongst patients with GGG 1–2 prostate cancer at biopsy
Authors: Yang Jinhui , Xiao Ling , Zhou Ming , Li Yujia , Cai Yi , Gan Yu , Tang Yongxiang , Hu Shuo 
Published: July 2024

Abstract
Purpose
To develop a radiomics-based model using [68Ga]Ga-PSMA PET/CT to predict postoperative adverse pathology (AP) in patients with biopsy Gleason Grade Group (GGG) 1–2 prostate cancer (PCa), assisting in the selection of patients for active surveillance (AS).

Methods
A total of 75 men with biopsy GGG 1–2 PCa who underwent radical prostatectomy (RP) were enrolled. The patients were randomly divided into a training group (70%) and a testing group (30%). Radiomics features of entire prostate were extracted from the [68Ga]Ga-PSMA PET scans and selected using the minimum redundancy maximum relevance algorithm and the least absolute shrinkage and selection operator regression model. Logistic regression analyses were conducted to construct the prediction models. Receiver operating characteristic (ROC) curve, decision curve analysis (DCA), and calibration curve were employed to evaluate the diagnostic value, clinical utility, and predictive accuracy of the models, respectively.

Results
Among the 75 patients, 30 had AP confirmed by RP. The clinical model showed an area under the curve (AUC) of 0.821 (0.695–0.947) in the training set and 0.795 (0.603–0.987) in the testing set. The radiomics model achieved AUC values of 0.830 (0.720–0.941) in the training set and 0.829 (0.624–1.000) in the testing set. The combined model, which incorporated the Radiomics score (Radscore) and free prostate-specific antigen (FPSA)/total prostate-specific antigen (TPSA), demonstrated higher diagnostic efficacy than both the clinical and radiomics models, with AUC values of 0.875 (0.780–0.970) in the training set and 0.872 (0.678–1.000) in the testing set. DCA showed that the net benefits of the combined model and radiomics model exceeded those of the clinical model.

Conclusion
The combined model shows potential in stratifying men with biopsy GGG 1–2 PCa based on the presence of AP at final pathology and outperforms models based solely on clinical or radiomics features. It may be expected to aid urologists in better selecting suitable patients for AS.
Bibliometric analysis of the application of deep learning in cancer from 2015 to 2023
Authors: Wang Ruiyu , Huang Shu , Wang Ping , Shi Xiaomin , Li Shiqi , Ye Yusong , Zhang Wei , Shi Lei , Zhou Xian , Tang Xiaowei 
Published: July 2024

Abstract
Background
Recently, the application of deep learning (DL) has made great progress in various fields, especially in cancer research. However, to date, the bibliometric analysis of the application of DL in cancer is scarce. Therefore, this study aimed to explore the research status and hotspots of the application of DL in cancer.

Methods
We retrieved all articles on the application of DL in cancer from the Web of Science database Core Collection database. Biblioshiny, VOSviewer and CiteSpace were used to perform the bibliometric analysis through analyzing the numbers, citations, countries, institutions, authors, journals, references, and keywords.

Results
We found 6,016 original articles on the application of DL in cancer. The number of annual publications and total citations were uptrend in general. China published the greatest number of articles, USA had the highest total citations, and Saudi Arabia had the highest centrality. Chinese Academy of Sciences was the most productive institution. Tian, Jie published the greatest number of articles, while He Kaiming was the most co-cited author. IEEE Access was the most popular journal. The analysis of references and keywords showed that DL was mainly used for the prediction, detection, classification and diagnosis of breast cancer, lung cancer, and skin cancer.

Conclusions
Overall, the number of articles on the application of DL in cancer is gradually increasing. In the future, further expanding and improving the application scope and accuracy of DL applications, and integrating DL with protein prediction, genomics and cancer research may be the research trends.
Evidence for suboceanic small-scale convection from a “garnet”-bearing lherzolite xenolith from Aitutaki Island, Cook Islands
Authors: Akizawa Norikatsu , Ozawa Kazuhito , Kogiso Tetsu , Ishikawa Akira , Miyake Akira , Igami Yohei , Wallis Simon R. , Nagaya Takayoshi , Ohshima Chihiro , Fujita Ryo , Kawamoto Tatsuhiko , Tamura Akihiro , Morishita Tomoaki , Arai Shoji , Yasumoto Atsushi 
Published: July 2024

AbstractGarnet peridotite xenoliths have been rarely reported from suboceanic mantle. Petrographic and geochemical characteristics of garnet-bearing oceanic peridotite xenoliths provide precious information on dynamics of the suboceanic lithosphere and asthenosphere interaction. We examined a lherzolite xenolith included in olivine nephelinite lava from Aitutaki Island, a member of the Cook-Austral volcanic chain. The lherzolite xenolith contains reddish fine-grained (< 5 µm in size) mineral aggregates (FMAs) with size range of 0.5–6 mm, consisting of olivine, calcic and sodic plagioclases, aluminous spinel, native iron, and nepheline. Microstructural observations and chemical data corroborate that the FMA is a decomposed pyrope-rich garnet including chromian spinel grains with an irregular highly indented morphology in the center. The FMA is surrounded by pyroxene-poor and olivine-rich aureole. The spatial and morphological relationships of FMA and chromian spinel with pyroxene-depleted margin suggest a reaction of aluminous spinel + pyroxenes → pyrope-rich garnet + olivine, which requires a compression before decomposition of the garnet to FMA. An orthopyroxene grain shows slight but clear chemical zoning characterized by increase in Al, Ca, and Cr from the grain center to the rim. The zoning patterns of Al and Ca in the orthopyroxene grain can be modeled by diffusion-controlled solid-state reactions induced by pressure and temperature changes, keeping surface concentrations in equilibrium with the other coexisting mineral phases. The results indicate that the mantle, from which the lherzolite xenolith was derived, underwent isothermal decompression followed by a weak heating on a time scale of a few tenths of million years before the xenolith extraction. From the deduced compression and decompression histories, we hypothesize that the mantle beneath Aitutaki Island was once dragged down to a garnet-stable deep mantle region and brought up later by small-scale sublithospheric convection.
Comparison of short-term clinical results between modified kinematically-aligned and guided motion bicruciate stabilized total knee arthroplasty
Authors: Anjiki Kensuke , Nakano Naoki , Ishida Kazunari , Takayama Koji , Fujita Masahiro , Kamenaga Tomoyuki , Tsubosaka Masanori , Kuroda Yuichi , Hayashi Shinya , Kuroda Ryosuke , Matsumoto Tomoyuki 
Published: July 2024

Abstract
Background
Both kinematically-aligned (KA) total knee arthroplasty (TKA) and bicruciate stabilized (BCS) TKA aim to reproduce the physiological knee kinematics. In this study, we compared the femoro-tibial component rotational mismatch between patients who underwent modified KA-TKA and those who received guided-motion BCS-TKA, and its influence on the clinical outcomes.

Methods
In this retrospective study, 77 consecutive patients were included and divided into two groups: subjects who underwent modified KA-TKA with Persona (KA Group; n = 42) and those who received BCS-TKA with JOURNEY II (BCS group; n = 35). Range of motion, the 2011 Knee Society Score (KSS), the rotational alignment of the femoral and tibial components, and the correlations between the rotational mismatch and the 2011 KSS subscales were examined.

Results
The postoperative objective knee indicators (P = 0.0157), patient satisfaction (P = 0.0039) and functional activity scores (P = 0.0013) in the KA group were significantly superior to those in the BCS group 1 year postoperatively. There was no significant difference between the two groups observed in the rotational mismatch. In the BCS group, significant negative correlations were identified between the rotational mismatch and objective indicators, patient satisfaction, and functional activity scores but not in the KA group.

Conclusions
The short-term clinical results following KA-TKA showed superior objective knee indicators, patient satisfaction and functional activity scores. A negative correlation was observed between component rotational mismatch and the 2011 KSS subscales in the BCS group, compared to no relationship found between the two in the KA group. These findings suggested that KA-TKA has a relatively higher tolerance for rotational mismatch than BCS-TKA.
The effect of right ventricle septal pacing versus apical pacing in dual-chamber pacemakers on patients’ anxiety and depression: a one-year follow-up study
Authors: El-Shirbiny Hassan , Biomy Reda , Haseeb Wael Anwar , Saboukh Islam 
Published: July 2024

Abstract
Background
Anxiety and depression are potentially harmful outcomes of permanent cardiac pacemakers. Dual-chamber P.P.M. is frequently used to treat life threatening bradycardia. The study aims to estimate the effect of the right ventricular PM lead position on recipients’ anxiety and depression before, 6 months, and 1 year after implantation.

Results
A statistically significant correlation was discovered between the studied groups regarding HADS depression score after 6 months (p 0.013) and 1 year (p 0.013). A statistically non-significant difference was found among the studied groups at any point of time regarding baseline (p 0.063), after 6 months (p 0.054), or after 1 year (p 0.099). Significance was found between HADS anxiety score (p 0.015) or depression score after 1 year and the incidence of complications (p 0.001).

Conclusions
A strong relationship was found between the level of depression and the R.V. site of implantation, as patients with the apical group had higher levels of depression post-implantation. The septal position has less stress and depression on the patient’s well-being than the apical one.