bluuebunny/crossref_metadata_2025_split huggingface dataset:
Agreement between patient‐reported and clinically documented symptoms of acute myeloid leukemia: Study protocol
Authors: Chae Sena , Bae Jaewon , Youn Nayung , Lopez Karen Dunn , Sutamtewagul Grerk , Rakel Barbara 
Published: July 2024

AbstractAimTo describe our methods to compare patient‐reported symptoms of acute myeloid leukemia and the corresponding documentation by healthcare providers in the electronic health record.BackgroundPatients with acute myeloid leukemia experience many distressing symptoms, particularly related to chemotherapy. The timely recognition and provision of evidence‐based interventions to manage these symptoms can improve outcomes. However, lack of standardized formatting for symptom documentation within electronic health records leads to challenges for clinicians when accessing and comprehending patients' symptom information, as it primarily exists in narrative forms in various parts of the electronic health record. This variability raises concerns about over‐ or under‐reporting of symptoms. Consistency between patient‐reported symptoms and clinician's symptom documentation is important for patient‐centered symptom management, but little is known about the degree of agreement between patient reports and their documentation. This is a detailed description of the study's methodology, procedures and design to determine how patient‐reported symptoms are similar or different from symptoms documented in electronic health records by clinicians.DesignExploratory, descriptive study.MethodsForty symptoms will be assessed as patient‐reported outcomes using the modified version of the Memorial Symptom Assessment Scale. The research team will annotate symptoms from the electronic health record (clinical notes and flowsheets) corresponding to the 40 symptoms. The degree of agreement between patient reports and electronic health record documentation will be analyzed using positive and negative agreement, kappa statistics and McNemar's test.ConclusionWe present innovative methods to comprehensively compare the symptoms reported by acute myeloid leukemia patients with all available electronic health record documentation, including clinical notes and flowsheets, providing insights into symptom reporting in clinical practice.ImpactFindings from this study will provide foundational understanding and compelling evidence, suggesting the need for more thorough efforts to assess patients' symptoms. Methods presented in this paper are applicable to other symptom‐intensive diseases.
Strategies to promote patient‐centeredness within the healthcare industry: A grey‐based multicriteria decision making methods
Authors: Khosravi Mohsen , Izadi Reyhane , Shojaei Payam , Delavari Sajad 
Published: July 2024

AbstractRationaleThe international policy agenda has recently advocated for the development of patient‐centeredness in healthcare service delivery. Consequently, various stakeholders in the healthcare systems have expressed a vital need for identifying strategies and tools that can enhance patient‐centeredness.Aims and ObjectivesThe objective of this paper was to prioritise and benchmark the strategies that can improve patient‐centeredness in healthcare service delivery.MethodWe employed a multi‐stage research scenario that consisted of two phases: a phase including of a scoping review to identify the current strategies to improve patient‐centeredness (PC); And, a phase including of a multicriteria best‐worst method to assign weights to PC principles, and a questionnaire administered to a sample of experts for benchmarking the strategies derived from the literature using the Grey Multi‐Attributive Border Approximation Area Comparison (MABAC‐G) method.ResultsThe most important principle of patient‐centeredness was deemed to be access to care, while telehealth tools and Electronic Health Information Systems were respectively suggested as the most efficacious platforms for promoting patient‐centeredness.ConclusionWe recommend that administrators and policy makers in the healthcare industry prioritise the implementation and research of strategies such as telehealth tools and electronic health information systems to enhance access and patient‐centeredness in the healthcare systems.
Doing right by families: Presenting dynamic performance metrics for legal excellence in child welfare law
Authors: Aleguire Zabrina , Gatowski Sophia 
Published: July 2024

AbstractTo meet the challenge of advancing child welfare law, a field affecting millions of families a year, practicing attorneys have developed a wealth of guidance for best practices. The Judicial, Court, and Attorney Measures of Performance (JCAMP) provide a way to determine whether legal programs are following these recommended practices and to assess the strength of attorney–client relationships. After providing context around challenges to high quality legal representation, best practice guidance, and evaluation research findings, this article reviews the JCAMP measures of attorney practice. JCAMP may be used by legal programs to both assess their own practice and to elicit feedback from affected families to ensure consistent high quality representation. Boldly assessing attorney interactions, and the experiences of clients in the court process, is critical to guiding and empowering lawyers to achieve excellence.
Assessing kiwifruit quality in storage through machine learning
Authors: Azadbakht Mohsen , Hashemi Shabankareh Shaghayegh , Kiapey Ali , Rezaeiasl Abbas , Mahmoodi Mohammad Javad , Torshizi Mohammad Vahedi 
Published: July 2024

AbstractToday, diets rich in fruits and vegetables are highly recommended since they contribute to health. The high deterioration rate of fruits distinguishes them from other crops. This study aimed to evaluate the effects of various storage conditions on some quality attributes of kiwifruit through machine learning (ML) using support vector machine (SVM) models. Kiwifruits were subjected to quasi‐static loading and coated with different coatings, such as grape, date, and mulberry syrups. Then, the coated kiwifruits were stored at humidity levels of 90% and 95% in completely dark and bright environments with a Compact fluorescent lamp (CFL) bulb for 5, 10, and 15 days. Once the storage period had been completed, quality attributes of the kiwifruit, including antioxidant content, phenolic content, total soluble solids (TSS), pH, and firmness were measured. Each test was performed three times. The numerical results were analyzed through an ML approach using an SVM model on MATLAB. To predict the physical properties of kiwifruit using storage conditions and vice versa, it was found that the most accurate SVM model with a linear kernel predicted the weight loss of kiwifruit based on storage conditions, with the coefficient of determination (R2) being 0.54. To predict the biochemical properties using the storage conditions and vice versa, it was found that kiwifruit firmness was most accurately predicted by the SVM model with the Gaussian kernel, with an R2 of 0.70. Moreover, humidity and storage duration were modeled by SVMs with linear kernels, calculating the coefficients of determination to be 0.39 and 0.90, respectively. To predict biochemical properties using physical properties and vice versa, it was observed that the weight loss was more accurately predicted by an SVM with a linear kernel, with an R2‐value of 0.76. Reliable results were not obtained for further research for the other modeled parameters using an SVM approach.Practical ApplicationsIt was found that light was most accurately predicted by the linear SVM. Storage conditions revealed SVM (linear kernel) accurately predicting kiwifruit weight loss. Linear and Gaussian SVMs accurately modeled phenolic and antioxidant content, R2‐values: 0.73 and 0.34, respectively.
Exosomal mRNA in plasma serves as a predictive marker for microvascular invasion in hepatocellular carcinoma
Authors: Xin Zhaodan , Chen Hao , Xu Jingtong , Zhang Haili , Peng Yufu , Ren Jing , Guo Qin , Song Jiajia , Jiao Lin , You Liting , Bai Ling , Wei Yonggang , Zhou Juan , Ying Binwu 
Published: July 2024

AbstractBackground and AimThere is a pressing need for non‐invasive preoperative prediction of microvascular invasion (MVI) in hepatocellular carcinoma (HCC). This study investigates the potential of exosome‐derived mRNA in plasma as a biomarker for diagnosing MVI.MethodsPatients with suspected HCC undergoing hepatectomy were prospectively recruited for preoperative peripheral blood collection. Exosomal RNA profiling was conducted using RNA sequencing in the discovery cohort, followed by differential expression analysis to identify candidate targets. We employed multiplexed droplet digital PCR technology to efficiently validate them in a larger sample size cohort.ResultsA total of 131 HCC patients were ultimately enrolled, with 37 in the discovery cohort and 94 in the validation cohort. In the validation cohort, the expression levels of RSAD2, PRPSAP1, and HOXA2 were slightly elevated while CHMP4A showed a slight decrease in patients with MVI compared with those without MVI. These trends were consistent with the findings in the discovery cohort, although they did not reach statistical significance (P > 0.05). Notably, the expression level of exosomal PRPSAP1 in plasma was significantly higher in patients with more than 5 MVI than in those without MVI (0.147 vs 0.070, P = 0.035).ConclusionThis study unveils the potential of exosome‐derived PRPSAP1 in plasma as a promising indicator for predicting MVI status preoperatively.
DDX3X syndrome: From clinical phenotypes to biological insights
Authors: von Mueffling Alexa , Garcia‐Forn Marta , De Rubeis Silvia 
Published: July 2024

AbstractDDX3X syndrome is a neurodevelopmental disorder accounting for up to 3% of cases of intellectual disability (ID) and affecting primarily females. Individuals diagnosed with DDX3X syndrome can also present with behavioral challenges, motor delays and movement disorders, epilepsy, and congenital malformations. DDX3X syndrome is caused by mutations in the X‐linked gene DDX3X, which encodes a DEAD‐box RNA helicase with critical roles in RNA metabolism, including mRNA translation. Emerging discoveries from animal models are unveiling a fundamental role of DDX3X in neuronal differentiation and development, especially in the neocortex. Here, we review the current knowledge of genetic and neurobiological mechanisms underlying DDX3X syndrome and their relationship with clinical phenotypes.image
Adherence to guideline‐recommended care of late‐onset hypertension in females versus males: A population‐based cohort study
Authors: Bugeja Ann , Girard Celine , Sood Manish M , Kendall Claire E , Sweet Ally , Singla Ria , Motazedian Pouya , Vinson Amanda J , Ruzicka Marcel , Hundemer Gregory L. , Knoll Greg , McIsaac Daniel I 
Published: July 2024

AbstractBackgroundSex‐based disparities in cardiovascular outcomes may be improved with appropriate hypertension management.ObjectiveTo compare the evidence‐based evaluation and management of females with late‐onset hypertension compared to males in the contemporary era.MethodsDesign: Retrospective population‐based cohort study.Setting: Ontario, Canada.Participants: Residents aged ≥66 years with newly diagnosed hypertension between January 1, 2010, and December 31, 2017.Exposure: Sex (female vs. male).Outcomes and Measures: We used Poisson and logistic regression to estimate adjusted sex‐attributable differences in the performance of guideline‐recommended lab investigations. We estimated adjusted differences in time to the prescription of, and type of, first antihypertensive medication prescribed between females and males, using Cox regression.ResultsAmong 111,410 adults (mean age 73 years, 53% female, median follow‐up 6.8 years), females underwent a similar number of guideline‐recommended investigations (adjusted incidence rate ratio, 0.997 [95% confidence interval [CI] 0.99–1.002]) compared to males. Females were also as likely to complete all investigations (0.70% females, 0.77% males; adjusted odds ratio, 0.96 [95% CI 0.83–1.11]). Females were slightly less likely to be prescribed medication (adjusted hazard ratio [aHR] 0.98 [95% CI 0.96–0.99]) or, among those prescribed, less likely to be prescribed first‐line medication (aHR, 0.995 [95% CI 0.994–0.997]).ConclusionsCompared to males, females with late‐onset hypertension were equally likely to complete initial investigations with comparable prescription rates. These findings suggest that there may be no clinically meaningful sex‐based differences in the initial management of late‐onset hypertension to explain sex‐based disparities in cardiovascular outcomes.
Toward a decolonial developmental science in Asia: Exploring adolescent development in communities from the majority world
Authors: Banati Prerna 
Published: July 2024

AbstractThe field of developmental science explores the rich interplay between individuals and their contexts, which dynamically shift across time and place. In Asia, context‐specific research and practice are essential for promoting culturally relevant program and policy approaches to improving adolescent well‐being. This involves critically examining how localized social structures and power dynamics shape individual experiences and outcomes. The landscape for Asian adolescents today differs significantly from that of previous generations due to rapid changes in these structures, and societal transformation has created the opportunity for traditional and modern values to coexist. This commentary draws across articles from this special issue to describe the dynamics of adolescent‐context relations across diverse Asian contexts using developmental science methods. This includes interrogating risk factors, opportunities, and trajectories for adolescents growing up in non‐Western settings while also questioning the application of Western, adult‐centric discourses on adolescent well‐being globally.
Sleep Deprivation Induces Gut Damage via Ferroptosis
Authors: Zheng Zi‐Jian , Zhang Hai‐Yi , Hu Ya‐Lin , Li Yan , Wu Zhi‐Hong , Li Zhi‐Peng , Chen Dong‐Rui , Luo Yang , Zhang Xiao‐Jing , Li Cang , Wang Xiao‐Yu , Xu Dan , Qiu Wei , Li Hong‐Ping , Liao Xiao‐Ping , Ren Hao , Sun Jian 
Published: July 2024

ABSTRACTSleep deprivation (SD) has been associated with a plethora of severe pathophysiological syndromes, including gut damage, which recently has been elucidated as an outcome of the accumulation of reactive oxygen species (ROS). However, the spatiotemporal analysis conducted in this study has intriguingly shown that specific events cause harmful damage to the gut, particularly to goblet cells, before the accumulation of lethal ROS. Transcriptomic and metabolomic analyses have identified significant enrichment of metabolites related to ferroptosis in mice suffering from SD. Further analysis revealed that melatonin could rescue the ferroptotic damage in mice by suppressing lipid peroxidation associated with ALOX15 signaling. ALOX15 knockout protected the mice from the serious damage caused by SD‐associated ferroptosis. These findings suggest that melatonin and ferroptosis could be targets to prevent devastating gut damage in animals exposed to SD. To sum up, this study is the first report that proposes a noncanonical modulation in SD‐induced gut damage via ferroptosis with a clearly elucidated mechanism and highlights the active role of melatonin as a potential target to maximally sustain the state during SD.
Chronic sleep deficiency and its impact on pain perception in healthy females
Authors: Rouhi Shima , Egorova‐Brumley Natalia , Jordan Amy S. 
Published: July 2024

SummaryAcute sleep deprivation in experimental studies has been shown to induce pain hypersensitivity in females. However, the impact of natural sleep deficiency and fluctuations across the week on pain perception remains unclear. A sleep‐monitoring headband and self‐reports were utilized to assess objective and subjective sleep in longer (> 6 hr) and short sleepers (< 6 hr). Pain sensitivity measures including heat, cold, pressure pain thresholds, pain inhibition (conditioned pain modulation) and facilitation (tonic pain summation) were assessed on Mondays and Fridays. Forty‐one healthy young (23.9 ± 0.74 years) women participated. Short sleepers slept on average 2 hr less than longer sleepers (297.9 ± 8.2 min versus 418.5 ± 10.9 min) and experienced impaired pain inhibitory response (mean = −21.14 ± 7.9°C versus mean = 15.39 ± 9.5°C; p = 0.005). However, no effect was observed in pain thresholds and pain summation (p > 0.05). Furthermore, pain modulatory responses differed between Mondays and Fridays. Chronic sleep deficiency (< 6 hr) compromises pain responses, notably on Mondays. Maintaining a consistent sleep pattern with sufficient sleep (> 6 hr) throughout the week may protect against pain sensitization and the development of chronic pain in females. Further research is needed, especially in patients with chronic pain.
Children need to see themselves in their reading material: parental perspectives on the importance of ethnically and culturally diverse reading material
Authors: Scorer Mary A. , Vardy Emma J. 
Published: July 2024

AbstractTo support children's engagement with reading material, it is important children are represented in reading material provided. As Parents are the curators of their child's reading diet, in this study the parental perspectives of the ethnic diversity of available reading material for their children was explored. Eight parents were interviewed individually online to explore their perceptions of diversity in their children's reading books. Interview scripts were analysed taking a reflexive thematic analysis approach. There was a commonality across all parents in that children's literature needed to represent the multicultural society their child lived in, but the emotional and personal content in this message differed between parents. To explain the data two themes of identify formation and ethnic diversity limitations of reading material are discussed. Identity formation encapsulated the parents focus on children needing to see themselves in reading material to learn about themselves and their culture. Therefore, it is important to avoid stereotyping which is the second theme. All parents noted the need for more diversity broadly in children's reading material, from publishers but also availability of diverse reading material from educational settings.
Inhibition of Monilinia fructicola sporulation and pathogenicity through eucalyptol‐mediated targeting of MfCat2 by Streptomyces lincolnensis strain JCP1‐7
Authors: Chen Shan , Yang Haorong , Chen Meijun , Liu Weina , Tian Shaorui , Mu Rong , Jia Fan , Liu Changyun , Ma Guanhua , Sun Xianchao , Chen Guokang 
Published: July 2024

AbstractPeach brown rot, attributed to Monilinia fructicola, presents a significant threat to postharvest peach cultivation, causing losses of up to 80%. With an increasing number of countries, spearheaded by the European Union, imposing bans on chemical agents in fruit production, there is a growing interest in mining highly active antibacterial compounds from biological control strains for postharvest disease management. In this study, we highlight the unique ability of Streptomyces lincolnensis strain JCP1‐7 to inhibit M. fructicola sporulation, despite its limited antimicrobial efficacy. Through GC–MS analysis, eucalyptol was identified as the key compound. Fumigation of diseased fruits with eucalyptol at a concentration of 0.0335 μg cm−3 demonstrated an in vivo inhibition rate against M. fructicola of 93.13%, completely suppressing spore formation. Transcriptome analysis revealed the impact of eucalyptol on multiple pathogenesis‐related pathways, particularly through the inhibition of catalase 2 (Cat2) expression. Experiments with a MfCat2 knockout strain (ΔMfCat2) showed reduced pathogenicity and sensitivity to JCP1‐7 and eucalyptol, suggesting MfCat2 as a potential target of JCP1‐7 and eucalyptol against M. fructicola. Our findings elucidate that eucalyptol produced by S. lincolnensis JCP1‐7 inhibits M. fructicola sporulation by regulating MfCat2, thereby effectively reducing postharvest peach brown rot occurrence. The use of fumigation of eucalyptol offers insights into peach brown rot management on a large scale, thus making a significant contribution to agricultural research.
Is there still a place for serum galactomannan in the diagnosis of invasive aspergillosis in children at high risk and under antifungal prophylaxis?
Authors: Gerard Rémy , Gabriel Frédéric , Accoceberry Isabelle , Imbert Sébastien , Ducassou Stéphane , Angoso Marie , Jubert Charlotte 
Published: July 2024

AbstractBackgroundThe performance of serum galactomannan (GM) for the diagnosis of invasive aspergillosis (IA) has been studied mainly in adults. Paediatric data are scarce and based on small and heterogeneous cohorts.ObjectiveTo evaluate the performance of serum GM for the diagnosis of IA in a paediatric oncologic population at high risk of IA and to clarify the impact of antifungal prophylaxis on this test.MethodsWe performed a retrospective study from January 2014 to December 2020 in the paediatric oncologic haematologic department of the University Hospital of Bordeaux. The diagnosis of IA was made using the recommendations of the EORTC and the MSGERC.ResultsAmong the 329 periods at high risk of IA in 222 patients, the prevalence of IA was 1.8% (3 proven and 3 probable IA). In the total population, the sensitivity, and the positive predictive value (PPV) were respectively 50% and 17.6%. Under antifungal prophylaxis, the sensitivity and PPV dropped, respectively, to 33.3% and 14.3%. In this group, the post‐test probability of IA was 2% for a negative serum GM and only 14%.ConclusionIn this large cohort of children at high risk of IA, the incidence of IA is low and the diagnostic performance of GM is poor, especially in the case of mould‐active prophylaxis. Screening should be targeted rather than systematic and should be reserved for patients at highest risk for IA without mould‐active prophylaxis. Combination with other tests such as Aspergillus PCR would increase the accuracy of GM in screening setting.
Patient capital and no net loss: Applying institutional theory to understand publicly‐owned mitigation banking in an urban context at a United States port
Authors: Thompson‐Spain Austin , Bunds Kyle S. , Larson Lincoln , Cutts Bethany , Hipp J. Aaron 
Published: July 2024

AbstractAs urban areas grow, ecosystem extent and condition continue to decline. Some countries have adopted “no net loss” policies that require compensatory actions for unavoidable ecosystem losses. In the US, mitigation banking has emerged as a means of offsetting losses, but the system remains dominated by private commercial banks and mitigation outside of an urban context. With this in mind, we seek to understand the institutional drivers of innovative finance for urban mitigation projects at the public agency level. Applying institutional logics and institutional isomorphisms as theoretical foundations, we conducted a qualitative case study of innovative finance for habitat restoration at the Port of Seattle, a public port in Seattle, Washington (USA). Findings from interviews, focus groups, and document analysis suggest that hybrid institutional logics, unique organizational characteristics, and coercive and normative isomorphisms drive organizational change in this context, but significant barriers exist to establishing similar systems in the US.