bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discrepancies of frequent symptoms in licorice‐induced pseudoaldosteronism: A comparison of a systematic case review and the Ministry of Health, Labour and Welfare's manual
Authors: Hattori Yuna , Asano Yoichi , Yoshino Tetsuhiro 
Published: July 2024

AbstractBackgroundLicorice‐induced pseudoaldosteronism has been identified as a side effect of excessive licorice consumption. This condition is often characterized by hypertension, hypokalemia, and hyporeninemic hypoaldosteronism. If left untreated, this condition can lead to severe complications, such as arrhythmia and rhabdomyolysis, which can be life‐threatening. Thus, it is critical to recognize the early symptoms of pseudoaldosteronism to facilitate prompt intervention and effective management. Here, we investigated the frequency of various accompanying symptoms by systematically reviewing case reports of licorice‐induced pseudoaldosteronism not covered in similar studies and comparing findings with the manual on pseudoaldosteronism published by the Ministry of Health, Labour and Welfare (MHLW).MethodsA comprehensive search was conducted using MEDLINE/PubMed to gather relevant human studies published between 1960 and July 2023 and written in English; data focusing on accompanying symptoms were summarized.ResultsThirty‐seven pertinent articles, encompassing 48 case reports (26 females and 1 unreported sex, mean age 64.6 ± 14.6), were identified and scrutinized. The analysis revealed that hypertension was the most prevalent followed by weakness and edema. None of the researched cases reported instances of spasticity or rigidity.DiscussionThe study findings identified hypertension and weakness followed by edema as the predominant symptoms associated with pseudoaldosteronism which is in agreement with the MHLW manual. However, we doubt that spasticity, rigidity, and possibly numbness could be noticed by patients and their families as common initial symptoms outlined in the manual.
Juzentaihoto alleviates cisplatin‐induced renal injury in mice
Authors: Yoshioka Hiroki , Tominaga Sarah , Amano Fumiya , Wu Sixun , Torimoto Shintaro , Moriishi Takeshi , Tsukiboshi Yosuke , Yokota Satoshi , Miura Nobuhiko , Inagaki Naoki , Matsushita Yuki , Maeda Tohru 
Published: July 2024

AbstractAimCisplatin is a highly effective anti‐cancer agent, but its clinical use is restricted due to severe renal toxicity. This study aimed to investigate the alleviative effects of juzentaihoto (JTT) in a mouse model of cisplatin‐induced renal injury.MethodsFour groups of seven‐week‐old male C57BL/6J mice (control, JTT, cisplatin, and JTT + cisplatin groups) were used in the study. The JTT and JTT + cisplatin groups received oral JTT (500 mg/kg) once a day for three days. After 24 h, the cisplatin, and JTT + cisplatin groups were intraperitoneally injected with cisplatin (15 mg/kg). The mice in each group were euthanized 72 h after cisplatin administration, and blood and kidney samples were collected.ResultsCisplatin injection decreased body weight and elevated plasma blood urea nitrogen and creatinine levels, while also increasing renal oxidative stress, inflammation, and cell death. These changes were alleviated by JTT administration. We also found that platinum accumulation in the kidneys following cisplatin injection was attenuated by JTT treatment. Furthermore, Mate1 expression levels (a cisplatin efflux transporter) were upregulated by JTT injection.ConclusionOur results demonstrated that JTT mitigated cisplatin‐induced renal injury in mice by alleviating oxidative stress, inflammation, and cell death, achieved through the upregulation of the cisplatin efflux transporter Mate1.
Synthesis of flexible magneto‐electric polyvinyl alcohol composites using hybrid filler particles of carbon quantum dots and cobalt nano for electromagnetic interference shielding application
Authors: Suresh T. , Kandavalli Sumanth Ratna , Rajendiran T. , Chanthirasekaran K. 
Published: July 2024

AbstractThe main objective of the study is to synthesis and characterization of flexible magneto‐electric Polyvinyl Alcohol (PVA) composites for Electromagnetic Interference (EMI) shielding applications, by incorporating carbon quantum dots extracted from lychee fruit husks and cobalt nanoparticles sourced from Plectranthus amboinicus. Comprehensive mechanical, dielectrical, magnetic, and shielding tests were conducted to assess the performance of these novel materials. The mechanical characteristics of the composites were assessed to gauge their flexibility and robustness. In this regard, PV4 displayed a substantial tensile strength of 68 MPa, while PV6 exhibited an enhanced shore‐D hardness rating of 47. PV6 demonstrates superior dielectric properties, including a higher dielectric constant and a lower loss tangent, which are crucial for optimizing EMI shielding efficiency. When it comes to magnetic characteristics such as magnetization, retentivity, and coercivity, the PV6 composite designation outperforms the other composites. Additionally, PV6 exhibits higher electromagnetic interference (EMI) shielding effectiveness, measuring at approximately 49.8 dB in the E band and 56.5 dB in the F band. Findings demonstrate that the integration of carbon quantum dots and cobalt nanoparticles into the matrix resulted in flexible composites with enhanced mechanical strength. The incorporation of cobalt contributed to notable magnetic properties, increasing the materials' magnetization and retentivity. The tests on electromagnetic interference (EMI) showed that the shielding effectiveness got improved. The composite materials were able to reduce interference from electromagnetic waves in the tested frequency ranges. These flexible magneto‐electric PVA composites, developed using sustainable sources such as lychee fruit husks and Plectranthus amboinicus, exhibit promising potential for EMI shielding applications in diverse industries, including telecommunications, aerospace, and electronics, where reliable interference control is essential for optimal performance and safety.Highlights
Cobalt nanoparticles sourced from Plectranthus amboinicus.
Carbon quantum dots are prepared from lychee fruit husks via controlled pyrolysis.
High tensile strength PVA composites prepared.
Highest dielectric constant of 8.2 achieved for composite PV6.
Higher wave shielding up to 56.5 dB achieved in “E” band.
Clinical approach to a rare case of hydrallantois in bitch
Authors: Sharma Akshay , Sharma Pururava , Sharma Jahanvi , Kumar Pravesh , Ahuja Ankit K. , Sood Pankaj , Kumar Rakesh 
Published: July 2024

AbstractThe present case describes the clinical, sonographic and histopathological findings of hydrallantois in bitch. After 55 days of the first mating, nulliparous Golden Retriever bitch was presented with a primary complaint of perceptible abdominal distension and dyspnoea for the last 3‒4 days. Ultrasonography revealed marked uterine distension with well appreciable anechoic to hypoechoic allantoic regions along with fetal stress. During caesarean section, a cumulative 2.75 L of placental fluid was recovered from allantoic portion with an altered electrolyte profile in comparison to maternal plasma. The histopathology examination of one fetal kidney corroborated tubular degeneration, suggesting nephrosis to be the concomitant aetiology. In conclusion, the clinical examination and ultrasonography provided provisional diagnosis of the condition; caesarean section proved to be an ideal option in order to prevent the dystocia or any other complication during whelping in a bitch even if none of the puppies survived. This approach, with supportive therapy ensures comprehensive care post‐treatment.
Radicular (periapical) cyst causing exophthalmos in a dog
Authors: Pérez López Luis Alejandro , Brash Robert , Tsvetanova Agata , García González Beatriz , Almansa Ruiz José Carlos 
Published: July 2024

AbstractA 10‐year‐old male neutered Bichon Frise presented for assessment of right unilateral exophthalmos. The ophthalmological assessment revealed signs of retrobulbar disease. Computed tomography of the head showed a cavitary, well‐defined, fluid‐filled structure, which displayed a strong peripheral rim of contrast enhancement, and was centred around the tooth roots of the right maxillary first and second molar teeth (109 and 110). Focused ultrasound‐guided fluid sampling and fine needle aspirates were obtained for diagnostic purposes. After discussing the case with a veterinary dentist, extraction of the 109 and 110 and debridement of the cyst were performed. Histopathology supported the suspicion of a radicular cyst. Radicular cysts, despite being benign lesions, need to be included as a possible differential in cases with exophthalmos due to their potential retrobulbar mass effect.
Toward a complex socio‐environmental understanding of drought: The contribution of the social sciences and humanities
Authors: Elie Marc 
Published: July 2024

AbstractThis review shows that there is a fertile field of study on drought within the humanities and social sciences that produces a complex scientific understanding of droughts as socio‐natural disasters whose origins, unfolding and impacts are shaped by both social and biophysical processes. Five cases where this research stands out are reviewed: the Dust Bowl of the 1930s, the droughts in the Sahel in the last third of the 20th century, desiccation as a colonial discourse, ontologies of drought and climate history. The review shows that unfortunately this body of work is largely ignored in natural science drought research. It proposes to eschew the dichotomy between drought as a physical phenomenon and its socioeconomic impacts by framing droughts as disasters. It calls for dialogue and cooperation between the sciences of nature and the sciences of society (including the humanities) to create an integrated field of drought research, in the hope that this may bring to the public debate convincing interpretations of current droughts in a dramatically changing climate.This article is categorized under:
Climate, History, Society, Culture > World Historical Perspectives
Shifting paradigm in electrochemical biosensing matrices comprising metal organic frameworks and their composites in disease diagnosis
Authors: Shubhangi  , Divya  , Rai Sanjay K. , Chandra Pranjal 
Published: July 2024

AbstractMetal Organic Frameworks (MOFs) are an evolving category of crystalline microporous materials that have grabbed the research interest for quite some time due to their admirable physio‐chemical properties and easy fabrication methods. Their enormous surface area can be a working ground for innumerable molecular adhesions and site for potential sensor matrices. They have been explored in the last decade for incorporation in electrochemical sensor matrices as diagnostic solutions for a plethora of diseases. This review emphasizes on some of the recent advancements in the area of MOF‐based electrochemical biosensors with focus on various important diseases and their significance in upgrading the sensor performance. It summarizes MOF‐based biosensors for monitoring biomarkers relevant to diabetes, viral and bacterial sepsis infections, neurological disorders, cardiovascular diseases, and cancer in a wide range of real matrices. The discussion has been supplemented with extensive tables elaborating recent trends in the field of MOF‐composite probe fabrication strategies with their respective sensing parameters. The article sums up the future scope of these materials in the field of biosensors and enlightens the reader with recent trends for future research scope.This article is categorized under:
Diagnostic Tools > Biosensing
Diagnostic Tools > Diagnostic Nanodevices
Application Potential of Pnp‐Switching Semiconductors
Authors: Deng Philipp , Hoffmann Matthias , Nilges Tom 
Published: July 2024

AbstractMaterials with tunable properties are often in the focus of materials science. Up to this point four different semiconducting materials and substitution variants have been found that are capable of switching between p‐ and n‐type conduction by a simple change in temperature. In this review, we illustrate previous findings of these pnp‐switching materials and current developments in functional implementations. While in the past decade, the scientific focus was primarily on discovering new materials that possess this intriguing switching effect, recently the first devices were successfully constructed and tested. Using the compounds, Ag18Cu3Te11Cl3 and AgCuS, that exhibit the pnp‐switching behaviour at approximately room temperature and 364 K, respectively, two single‐material diodes were developed and characterized. The approach for inducing this effect is denoted and the fundamental principles for realizing these devices are summarized.
Understanding Urbanization
Authors: Evers David , Katurić Ivana , van der Wouden Ries 
Published: July 2024

AbstractThis chapter provides an overview of the historical context and contemporary perspectives on urbanization within Europe, emphasizing the sustainability challenges associated with land-use changes. A conceptual framework is presented which introduces key concepts and illustrates the input (drivers), production (decision-making), and outcomes (land conversion and urban form) of urbanization. The driving forces include exogenous factors, such as demographic shifts and economic changes, and endogenous factors, such as infrastructure development, finances, and spatial planning. Production consists of land development practices. Outcomes are described by the amount of urbanization as well as its form (compact, polycentric, and diffuse). The chapter closes with a reflection on sustainability.
Urbanization Interventions: Strategies, Plans, and Policies
Authors: Evers David , Katurić Ivana , van der Wouden Ries 
Published: July 2024

AbstractThis chapter explores the successes and challenges of managing urban growth. It examines the influence of formal and informal rules in society on urban development, drawing on examples of strategic planning and transit-oriented development in cities such as Stockholm, Amsterdam, and Paris. Despite ample qualitative evidence regarding the importance of national planning systems, it is difficult to establish a statistically significant causal link between planning systems and their ability to control urban development. The evidence also shows an increasing impact of European policies and strategies, such as the European Green Deal, on urbanization despite the absence of a mandate for planning.
Exact results for giant graviton four-point correlators
Authors: Brown Augustus , Galvagno Francesco , Wen Congkao 
Published: July 2024

Abstract
We study the four-point correlator $$ \left\langle {\mathcal{O}}_2{\mathcal{O}}_2\mathcal{DD}\right\rangle $$

O
2

O
2

DD

in $$ \mathcal{N} $$
N
= 4 super Yang-Mills theory (SYM) with SU(N) gauge group, where $$ {\mathcal{O}}_2 $$

O
2

represents the superconformal primary operator with dimension two, while $$ \mathcal{D} $$
D
denotes a determinant operator of dimension N, which is holographically dual to a giant graviton D3-brane extending along S5. We analyse the integrated correlator associated with this observable, obtained after integrating out the spacetime dependence over a supersymmetric invariant measure. Similarly to other classes of integrated correlators in $$ \mathcal{N} $$
N
= 4 SYM, this integrated correlator can be computed through supersymmetric localisation on the four-sphere. Employing matrix-model recursive techniques, we demonstrate that the integrated correlator can be reformulated as an infinite sum of protected three-point functions with known coefficients. This insight allows us to circumvent the complexity associated with the dimension-N determinant operator, significantly streamlining the large-N expansion of the integrated correlator. In the planar limit and beyond, we derive exact results for the integrated correlator valid for all values of the ’t Hooft coupling, and investigate the resurgent properties of their strong coupling expansion. Additionally, in the large-N expansion with fixed (complexified) Yang-Mills coupling, we deduce the SL(2, ℤ) completion of these results in terms of the non-holomorphic Eisenstein series. The proposed modular functions are confirmed by explicit instanton calculations from the matrix model, and agree with expectations from the holographic dual picture of known results in type IIB string theory.
Limits on heavy neutral leptons, Z′ bosons and majorons from high-energy supernova neutrinos
Authors: Akita Kensuke , Im Sang Hui , Masud Mehedi , Yun Seokhoon 
Published: July 2024

Abstract
Light hypothetical particles with masses up to $$ \mathcal{O}(100) $$
O

100

MeV can be produced in the core of supernovae. Their subsequent decays to neutrinos can produce a flux component with higher energies than the standard flux. We study the impact of heavy neutral leptons, Z′ bosons, in particular $$ \textrm{U}{(1)}_{L_{\mu }-{L}_{\tau }} $$
U

1

L
μ

−

L
τ

and U(1)B−L gauge bosons, and majorons coupled to neutrinos flavor-dependently. We obtain new strong limits on these particles from no events of high-energy SN 1987A neutrinos and their future sensitivities from observations of galactic supernova neutrinos.
Nuclear translocation of ISG15 regulated by PPP2R2B inhibits cisplatin resistance of bladder cancer
Authors: Huang Gaowei , Liu Jinwen , Yu Anze , Luo Chenggong , Zhu Jiangquan , Wang Yinghan , Dai Ziran , Zhang Lizhen , Feng Zihao , Lu Jun , Dong Zhong , Luo Junhang , Chen Wei , Chen Zhenhua 
Published: July 2024

AbstractCisplatin resistance is a major challenge for systemic therapy against advanced bladder cancer (BC). Little information is available on the regulation of cisplatin resistance and the underlying mechanisms require elucidation. Here, we detected that downregulation of the tumor suppressor, PPP2R2B (a serine/threonine protein phosphatase 2 A regulatory subunit), in BC promoted cell proliferation and migration. What’s more, low PPP2R2B expression was correlated with cisplatin resistance. In vitro and in vivo experiments verified that PPP2R2B could promote BC sensitivity to cisplatin. In terms of mechanism, we identified a novel function of PPP2R2B as a nucleocytoplasmic transport molecule. PPP2R2B promoted ISG15 entry into the nucleus by mediating binding of IPO5 with ISG15. Nuclear translocation of ISG15 inhibited DNA repair, further increasing ISG15 expression through activation of the STING pathway. Besides, PPP2R2B was down-regulated by SUV39H1-mediated histone 3 lysine 9 trimethylation, which could be restored by the SUV39H1-specific inhibitor, chaetocin. Our data suggest that PPP2R2B expression level is a potential biomarker for chemotherapy response and that chemotherapy in combination with chaetocin may be a feasible treatment strategy for patients with BC.
The viscoelastic paradox in a nonlinear Kelvin–Voigt type model of dynamic fracture
Authors: Caponi Maicol , Carbotti Alessandro , Sapio Francesco 
Published: July 2024

AbstractIn this paper, we consider a dynamic model of fracture for viscoelastic materials, in which the constitutive relation, involving the Cauchy stress and the strain tensors, is given in an implicit nonlinear form. We prove the existence of a solution to the associated viscoelastic dynamic system on a prescribed time-dependent cracked domain via a discretization-in-time argument. Moreover, we show that such a solution satisfies an energy-dissipation balance in which the energy used to increase the crack does not appear. As a consequence, in analogy to the linear case this nonlinear model exhibits the so-called viscoelastic paradox.
The effect of Porter’s competitive forces on competitive advantage and organisational performance and the moderating role of management accounting practices
Authors: Baird Kevin , Nuhu Nuraddeen , Jiao Lu 
Published: July 2024

AbstractThis study examines the effect of the intensity of competitive forces on organisational performance and competitive advantage and the moderating role of the use of traditional and contemporary management accounting practices on this relationship. Using survey data collected from 505 US-based financial managers, the findings indicate that the use of traditional management accounting practices was found to positively moderate the effect of the intensity of competitive forces on competitive advantage. Additional exploratory analysis revealed that the extent of use of contemporary management accounting practices positively moderates the effect of the intensity of competitive forces on organisational performance in a product differentiation/high-force environment. The extent of use of contemporary management accounting practices was also found to positively moderate the effect of the intensity of competitive forces on competitive advantage in a low-cost/high-force. However, the extent of use of contemporary management accounting practices was found to negatively moderate the effect of the intensity of competitive forces on competitive advantage in a product differentiation/low-force environment. Finally, the extent of use of traditional management accounting practices was found to negatively moderate the effect of the intensity of competitive forces on organisational performance in the product differentiation/high-force model. These findings provide a preliminary insight into the important role of management accounting practices in the management of competitive forces.
Diagnostic accuracy and reliability of CT-based Node-RADS for colon cancer
Authors: Leonhardi Jakob , Mehdorn Matthias , Stelzner Sigmar , Scheuermann Uwe , Höhn Anne-Kathrin , Seehofer Daniel , Schnarkowski Benedikt , Denecke Timm , Meyer Hans-Jonas 
Published: July 2024

Abstract
Objective
The Node-RADS classification was recently published as a classification system to better characterize lymph nodes in oncological imaging. The present analysis investigated the diagnostic benefit of the Node-RADS classification of staging computed tomography (CT) images to categorize and stage lymph nodes in patients with colon cancer.

Materials and methods
All patients were surgically resected and the lymph nodes were histopathological analyzed. All investigated lymph nodes were scored in accordance to the Node-RADS classification by two experienced radiologists. Interreader variability was assessed with Cohen’s kappa analysis, discrimination analysis was performed with Mann-Whitney-U test and diagnostic accuracy was assessed with receiver-operating characteristics (ROC) curve analysis.

Results
Overall, 108 patients (n = 49 females, 45.3%) with a mean age of 70.08 ± 14.34 years were included. In discrimination analysis, the total Node-RADS score showed statistically significant differences between N- and N + stage (for reader 1: mean 1.89 ± 1.09 score for N- versus 2.93 ± 1.62 score for N+, for reader 2: 1.33 ± 0.48 score for N- versus 3.65 ± 0.94 score for N+, p = 0.001, respectively). ROC curve analysis for lymph node discrimination showed an area under the curve of 0.68. A threshold value of 2 resulted in a sensitivity of 0.62 and a specificity of 0.71.

Conclusion
Node-RADS score derived from staging CT shows only limited diagnostic accuracy to correctly predict nodal positivity in colon cancer. The interreader variability seems to be high and should question the clinical translation for this tumour entity.