bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-Frequency Radars: Beamforming Calibrations Using Ships as Reflectors*
Authors: Flores-Vidal X. , Flament P. , Durazo R. , Chavanne C. , Gurgel K.-W. 
Published: November 2012

AbstractLinear array antennas and beamforming techniques offer some advantages compared to direction finding using squared arrays. The azimuthal resolution depends on the number of antenna elements and their spacing. Assuming an ideal beam pattern and no amplitude taper across the aperture, 16 antennas in a linear array spaced at half the electromagnetic wavelength theoretically provide a beam resolution of 3.5° normal to the array, and up to twice that when the beam is steered within an azimuthal range of 60° from the direction normal to the array. However, miscalibrated phases among antenna elements, cables, and receivers (e.g., caused by service activities without recalibration) can cause errors in the beam-steering direction and distortions of the beam pattern, resulting in unreliable ocean surface current and wave estimations. The present work uses opportunistic ship echoes randomly received by oceanographic high-frequency radars to correct an unusual case of severe phase differences between receiver channels, leading to a dramatic improvement of the surface current patterns. The method proposed allows for simplified calibrations of phases to account for hardware-related changes without the need to conduct the regular calibration procedure and can be applied during postprocessing of datasets acquired with insufficient calibration.
A New Parametric Tropical Cyclone Tangential Wind Profile Model
Authors: Wood Vincent T. , White Luther W. , Willoughby Hugh E. , Jorgensen David P. 
Published: November 2012

AbstractA new parametric tropical cyclone (TC) wind profile model is presented for depicting representative surface pressure profiles corresponding to multiple-maxima wind profiles that exhibit single-, dual-, and triple-maximum concentric-eyewall wind peaks associated with the primary (inner), secondary (first outer), and tertiary (second outer) complete rings of enhanced radar reflectivity. One profile employs five key parameters: tangential velocity maximum, radius of the maximum, and three different shape velocity parameters related to the shape of the profile. After tailoring the model for TC applications, a gradient wind is computed from a cyclostrophic wind formulated in terms of the cyclostrophic Rossby number. A pressure, via cyclostrophic balance, was partitioned into separate pressure components that corresponded to multiple-maxima cyclostrophic wind profiles in order to quantitatively evaluate the significant fluctuations in central pressure deficits. The model TC intensity in terms of varying growth, size, and decay velocity profiles was analyzed in relation to changing each of five key parameters. Analytical results show that the first shape velocity parameter, changing a sharply to broadly peaked wind profile, increases the TC intensity and size by producing the corresponding central pressure fall. An increase (decrease) in the second (third) shape velocity parameter yields the pressure rise (fall) by decreasing (increasing) the inner (outer) wind profile inside (outside) the radius of the maximum. When a single-maximum tangential wind profile evolves to multiple-maxima tangential wind profiles during an eye replacement cycle, the pressure falls and rises are sensitively fluctuated.
A Five-Year Radar-Based Climatology of Tropopause Folds and Deep Convection over Wales, United Kingdom
Authors: Antonescu Bogdan , Vaughan Geraint , Schultz David M. 
Published: November 2012

AbstractA five-year (2006–10) radar-based climatology of tropopause folds and convective storms was constructed for Wales, United Kingdom, to determine how deep, moist convection is modulated by tropopause folds. Based on the continuous, high-resolution data from a very high frequency (VHF) wind-profiling radar located at Capel Dewi, Wales, 183 tropopause folds were identified. Tropopause folds were most frequent in January with a secondary maximum in July. Based on data from the U.K. weather radar network, a climatology of 685 convective storms was developed. The occurrence of convective storms was relatively high year-round except for an abrupt minimum in February–April. Multicellular lines (43.5%) were the most common morphology with a maximum in October, followed by isolated cells (33.1%) with a maximum in May–September, and nonlinear clusters (23.4%) with a maximum in November–January. Convective storms were associated with 104 (56.8%) of the tropopause folds identified in this study, with the association strongest in December. Of the 55 tropopause folds observed on the eastern side of an upper-level trough, 37 (67.3%) were associated with convective storms, most commonly in the form of multicellular lines. Of the 128 tropopause folds observed on the western side of an upper-level trough, 42 (32.8%) were associated with convective storms, most commonly isolated cells. These results suggest that more organized storms tend to form in environments favorable for synoptic-scale ascent.
Why do we want the right to die? A systematic review of the international literature on the views of patients, carers and the public on assisted dying
Authors: Hendry Maggie , Pasterfield Diana , Lewis Ruth , Carter Ben , Hodgson Daniel , Wilkinson Clare 
Published: November 2012

Background: Assisted dying is legal in four European countries and three American states. Elsewhere, particularly in more affluent or mainly Protestant countries, it remains controversial. Dominant headlines feature professional (medical, legal, religious) arguments versus celebrity campaigners; ordinary people are less clearly represented. Aim: To synthesise the international evidence of people’s views and attitudes towards assisted dying in order to inform current debate about this controversial issue. Design: Systematic review and mixed method synthesis of qualitative and survey data Data sources: Eleven electronic databases from inception to October 2011; bibliographies of included studies Review Methods: Two reviewers independently screened papers and appraised quality. Qualitative results were extracted verbatim; survey results were summarised in a table. Qualitative data were synthesised using framework methods and survey results integrated where they supported, contrasted or added to the themes identified. Results: Sixteen qualitative studies and 94 surveys were included; many participants considered the immediate relevance of assisted dying for them. Themes related to poor quality of life, a good quality of death, potential abuse of assisted dying and the importance of individual stance. People valued autonomy in death as much as in life. Attitudes were diverse, complex and related to definitions of unbearable suffering including physical, psycho-social and existential factors and were consistent regardless of social, economic, legal and health-care contexts. Conclusion: Our review sheds light on ordinary people’s perspectives about assisted dying, when they are ill or disabled. Unbearable suffering is a key construct, and common factors are revealed that lead people to ask for help to die. The consistency of international views indicates a mandate for legislative and medical systems worldwide to listen and understand this.
Off-label prescribing in palliative care – a cross-sectional national survey of Palliative Medicine doctors
Authors: To Timothy HM , Agar Meera , Shelby-James Tania , Abernethy Amy P , Doogue Matthew , Rowett Debra , Ko Danielle , Currow David C 
Published: November 2012

Background: Regulatory bodies including the European Medicines Agency register medications (formulation, route of administration) for specific clinical indications. Once registered, prescription is at clinicians’ discretion. Off-label use is beyond the registered use. While off-label prescribing may, at times, be appropriate, efficacy and toxicity data are often lacking. Aim: The aim of this study was to document off-label use policies (including disclosure and consent) in Australian palliative care units and current practices by palliative care clinicians. Design: A national, cross-sectional survey was conducted online following an invitation letter. The survey asked clinicians their most frequent off-label medication/indication dyads and unit policies. Dyads were classified into unregistered, off-label and on-label, and for the latter, whether medications were nationally subsidised. Setting/participants: All Australian palliative medicine Fellows and advanced trainees. Results: Overall, 105 clinicians responded (53% response rate). The majority did not have policies on off-label medications, and documented consent rarely. In all, 236 medication/indication dyads for 36 medications were noted: 45 dyads (19%) were for two unregistered medications, 118 dyads (50%) were for 26 off-label medications and 73 dyads (31%) were for 12 on-label medications. Conclusions: Off-label prescribing with its clinical, legal and ethical implications is common yet poorly recognised by clinicians. A distinction needs to be made between where quality evidence exists but registration has not been updated by the pharmaceutical sponsor and the evidence has not been generated. Further research is required to quantify any iatrogenic harm from off-label prescribing in palliative care.
Exercise in the community for people with minimal gait impairment due to MS: an assessor-blind randomized controlled trial
Authors: Garrett M , Hogan N , Larkin A , Saunders J , Jakeman P , Coote S 
Published: November 2012

Background: While there is an increasing body of evidence supporting the efficacy of exercise in people with multiple sclerosis (MS), additional information on the effectiveness of combining aerobic and resistance training, and yoga is required. Objectives: This study evaluated the effectiveness of community exercise interventions for people with MS having minimal gait impairment. Methods: A multi-centred, block-randomised, assessor-blinded, controlled trial was conducted. Participants were randomised in groups of eight to physiotherapist (PT)-led exercise ( n = 80), yoga ( n = 77), fitness instructor (FI)-led exercise ( n = 86) and they took part in weekly community-based group exercise sessions. Those in the control group were asked not to change of their exercise habits ( n = 71). The primary outcome was the Multiple Sclerosis Impact Scale (MSIS) 29v2 physical component, measured before and after the 10-week intervention. Secondary outcomes were the MSIS 29v2 psychological component, the Modified Fatigue Impact Scale (MFIS) and the 6-Minute Walk Test (6MWT). Results: The group x time interaction approached significance for the MSIS-29v2 physical component ( f = 2.48, p = 0.061) and MFIS total ( f = 2.50, p = 0.06), and it was significant for the MFIS physical subscale ( f = 4.23, p = 0.006). All three exercise interventions led to a statistically significant improvement on the MSIS-29 psychological component and both the MFIS total and physical subscales, which were greater than the control ( p < 0.05). Only the PT-led and FI-led interventions significantly improved the MSIS-29 physical and 6MWT to levels greater than the control ( p < 0.05). Conclusions: This study provides evidence for the positive effect of exercise on the physical impact of MS and fatigue. The group nature of the classes may have contributed to the positive effects seen on the psychological impact of MS.
Acute disseminated encephalomyelitis followed by recurrent or monophasic optic neuritis in pediatric patients
Authors: Huppke Peter , Rostasy Kevin , Karenfort Michael , Huppke Brenda , Seidl Rainer , Leiz Steffen , Reindl Markus , Gärtner Jutta 
Published: November 2012

Background: Some pediatric patients with inflammatory demyelinating central nervous system disorders cannot be classified under any of the established disease entities, making their treatment and prognosis difficult. Objective: The objective of this study is to characterize a subgroup of pediatric patients with recurrent demyelinating central nervous system disorders. Methods: This study includes a case series of pediatric patients with monophasic or recurrent acute disseminated encephalomyelitis (ADEM) who later presented with either monophasic or recurrent optic neuritis (ON). Results: We describe seven patients with a median follow-up of six years (five females, two males) who presented at a median age of 6 years (range 4–8 years) with monophasic ( n = 4) or recurrent ADEM (two to four attacks) followed by monophasic ( n = 3) or recurrent ON (two to nine attacks). Cranial magnetic resonance imaging (MRI) was typical for ADEM ( n = 6) with complete or almost complete resolution of lesions on follow-up. Cerebrospinal (CSF) studies at the time of ADEM showed a pleocytosis in six patients and were negative for oligoclonal bands (OCBs) in all. In all patients high titers for serum anti-MOG antibodies were detected. Conclusion: ADEM followed by ON is a rare but distinct clinical phenotype among pediatric patients. Further studies are needed to allow recommendations on treatment or prognosis.
Chronic pain management strategies used by low-income overweight Latinos
Authors: Rutledge Dana N , Cantero Patricia J , Ruiz Jeanette E 
Published: November 2012

Objective: The objective of this study is to examine the strategies used to manage chronic pain from the perspective of the individual in group interviews. Methods: Sixteen low-income overweight Latino adults participated in two group interviews facilitated by a trained moderator who inquired about the type of chronic pain suffered by participants, followed by more specific questions about pain management. Interviews were audio-recorded, transcribed verbatim (Spanish), back-translated into English, and analyzed using thematic analysis. Results: Participants’ pain varied in type, location, and intensity. Participants discussed pain-related changes in activities and social life, and difficulties with health care providers, and as a result, we discovered five major themes: pain-related life alterations, enduring the pain, trying different strategies, emotional suffering, and encounters with health care system/providers. Discussion: Findings indicated that there are opportunities for providers to improve care for low-income overweight Latinos with chronic pain by listening respectfully to how pain alters their daily lives and assisting them in feasible self-management strategies.
Living with chronic pancreatitis: a qualitative study
Authors: Cronin Patricia , Begley Cecily 
Published: November 2012

Objective: Recent literature acknowledges the impact of this progressive and debilitating disease on psychological and social well-being, but the plight of those with chronic pancreatitis remains unknown and hidden. The aim of this study was to develop an understanding of what it means to live with chronic pancreatitis. Design: Qualitative study based on philosophical hermeneutics using multiple unstructured interviews. Participants: Fourteen people with chronic pancreatitis and five relatives took part in 41 interviews in 2007–2008. Setting: Tertiary clinic in Ireland. Results: The meaning of living with chronic pancreatitis for participants in this study is ‘enduring disruption’. Enduring has a two-fold meaning; it symbolises the perpetual or permanent nature of disruption that occurs at physiological, social and psychological levels (i.e., ‘suffering’). Enduring also means ‘to tolerate’ and encompasses how the participants and their families cope and manage the overall transition from well person to a person with chronic pancreatitis. Discussion: This study offers an alternative perspective to previous quality of life research and presents a challenge to the emphasis on management of the pathophysiological processes and treatment of chronic pancreatitis that is decontextualised from the person’s everyday living. Healthcare professionals need to understand and support people with chronic pancreatitis.
Zincalstibite-9R: the first nine-layer polytype with the layered double hydroxide structure-type
Authors: Mills S. J. , Christy A. G. , Kampf A. R. , Housley R. M. , Favreau G. , Boulliard J.-C. , Bourgoin V. 
Published: November 2012

AbstractZincalstibite-9R, a new polytype in the hydrotalcite supergroup is reported from the Monte Avanza mine, Italy. It occurs as pale blue curved disc-like tablets flattened on {001} intergrown to form rosettes typically less than 50 μm in diameter, with cyanophyllite and linarite in cavities in baryte. Zincalstibite-9R is uniaxial (–), with refractive indices ω = 1.647(2) and ε = 1.626(2) measured in white light. The empirical formula (based on 12 OH groups) is (Zn1.092+Cu0.872+Al0.04)Σ2.00Al1.01(Sb0.975+Si0.02)Σ0.99(OH)12, and the ideal formula is (Zn,Cu)2Al(OH)6[Sb(OH)6]. Zincalstibite-9R crystallizes in space group R, with a = 5.340(2), c = 88.01(2) Å, V = 2173.70(15) Å3 and Z = 9. The crystal structure was refined to R1 = 0.0931 for 370 unique reflections [Fo > 4σ(F)] and R1 = 0.0944 for all 381 unique reflections. It has the longest periodic layer stacking sequence for a layered double hydroxide compound reported to date.
Palenzonaite, berzeliite, and manganberzeliite: (As5+, V5+, Si4+)O4 tetrahedra in garnet structures
Authors: Nagashima M. , Armbruster T. 
Published: November 2012

AbstractSchäferite, NaCa2Mg2(V5+O4)3; palenzonaite, NaCa2Mn22+(V5+O4)3; berzeliite, NaCa2Mg2(As5+O4)3; and manganberzeliite, NaCa2Mn2+2(As5+O4)3, are cubic minerals with garnet structures (space group Iad) in which tetrahedrally coordinated V5+ and/or As5+ at the Z site are charge balanced by disordered Na+ and Ca2+ at the X site, and divalent Mg2+ and Mn2+ cations at the octahedrally coordinated Y site. The crystal chemistry of palenzonaite (from the Molinello and Gambatesa mines, Italy, and the Fianel mine, Switzerland), berzeliite (from Långban, Sweden, and Montaldo, Italy), and manganberzeliite (from Varenche, Italy, and the Gozaisho mine, Japan) were studied by electron microprobe analysis and single-crystal X-ray diffraction methods. Structure refinements converged to R1 values of 1.36–2.42%. The tetrahedral site in these garnet structures is mainly occupied by pentavalent As5+ or V5+ (only up to about 20% randomly distributed Si4+ is present). Charge balance is maintained by variations in the Ca/Na ratio at the X site. Heterovalent substitution (Na+ ↔ Ca2+) at the distorted square antiprism X site in vanadate- and arsenate-bearing garnets allows full occupancy of the octahedral Y site by divalent cations (primarily Mg2+ and Mn2+). There is a positive correlation between the <Z–O> and <Y–O> bond lengths and the mean ionic radii of the substituent elements, but there is no correlation between the <X–O> bond length and the variable Na/Ca site occupancy. The ionic radii of octahedrally coordinated Mg2+ and Mn2+ are such that the shared octahedral–dodecahedral edges are similar in length to the unshared octahedral edges, which is a measure of lattice distortion in garnet structures.
Spleen endothelial cells from patients with myelofibrosis harbor the JAK2V617F mutation
Authors: Rosti Vittorio , Villani Laura , Riboni Roberta , Poletto Valentina , Bonetti Elisa , Tozzi Lorenzo , Bergamaschi Gaetano , Catarsi Paolo , Dallera Elena , Novara Francesca , Massa Margherita , Campanelli Rita , Fois Gabriela , Peruzzi Benedetta , Lucioni Marco , Guglielmelli Paola , Pancrazzi Alessandro , Fiandrino Giacomo , Zuffardi Orsetta , Magrini Umberto , Paulli Marco , Vannucchi Alessandro M. , Barosi Giovanni 
Published: November 2012

Abstract
Increased microvessel density contributes to abnormal BM and spleen microenvironment in myelofibrosis (MF). Taking advantage of the JAK2V617F mutation as a marker of malignancy, in the present study, we investigated whether splenic endothelial cells (ECs) obtained from capillaries by laser microdissection or from fresh spleen tissue by cell culture or cell sorting harbored such mutation in patients bearing the mutation in their granulocytes and undergoing splenectomy for therapeutical reasons. To extend the analysis to the ECs of large vessels, endothelial tissue from the splenic vein was also studied. We found JAK2V617F+ ECs in 12 of 18 patients also bearing the mutation in their granulocytes. In 3 patients, the mutation was found in at least 2 different EC samples obtained by laser microdissection, cell culture, or cell sorting. The mutation was detected in the splenic vein ECs of 1 of 6 patients investigated. In conclusion, we provide evidence that some ECs from the spleen and splenic veins of patients with MF bear the JAK2V617F mutation. We suggest that splenic ECs are involved in the process of malignant transformation in MF.
Harmonic function for which the second dilatation is α-spiral
Authors: Aydog̃an Melike , Duman Emel Yavuz , Polatog̃lu Yaşar , Kahramaner Yasemin 
Published: November 2012

Abstract
Let

f
=
h
+

g
¯

be a harmonic function in the unit disc

D

. We will give some properties of f under the condition the second dilatation is α-spiral.

MSC:30C45, 30C55.
mGOASVM: Multi-label protein subcellular localization based on gene ontology and support vector machines
Authors: Wan Shibiao , Mak Man-Wai , Kung Sun-Yuan 
Published: November 2012

Abstract

Background
Although many computational methods have been developed to predict protein subcellular localization, most of the methods are limited to the prediction of single-location proteins. Multi-location proteins are either not considered or assumed not existing. However, proteins with multiple locations are particularly interesting because they may have special biological functions, which are essential to both basic research and drug discovery.

Results
This paper proposes an efficient multi-label predictor, namely mGOASVM, for predicting the subcellular localization of multi-location proteins. Given a protein, the accession numbers of its homologs are obtained via BLAST search. Then, the original accession number and the homologous accession numbers of the protein are used as keys to search against the Gene Ontology (GO) annotation database to obtain a set of GO terms. Given a set of training proteins, a set of T relevant GO terms is obtained by finding all of the GO terms in the GO annotation database that are relevant to the training proteins. These relevant GO terms then form the basis of a T-dimensional Euclidean space on which the GO vectors lie. A support vector machine (SVM) classifier with a new decision scheme is proposed to classify the multi-label GO vectors. The mGOASVM predictor has the following advantages: (1) it uses the frequency of occurrences of GO terms for feature representation; (2) it selects the relevant GO subspace which can substantially speed up the prediction without compromising performance; and (3) it adopts an efficient multi-label SVM classifier which significantly outperforms other predictors. Briefly, on two recently published virus and plant datasets, mGOASVM achieves an actual accuracy of 88.9% and 87.4%, respectively, which are significantly higher than those achieved by the state-of-the-art predictors such as iLoc-Virus (74.8%) and iLoc-Plant (68.1%).

Conclusions
mGOASVM can efficiently predict the subcellular locations of multi-label proteins. The mGOASVM predictor is available online athttp://bioinfo.eie.polyu.edu.hk/mGoaSvmServer/mGOASVM.html.