bluuebunny/crossref_metadata_2025_split huggingface dataset:
Thiyl Glycosylation of Propargylated Octasilsesquioxane: Synthesis and Lectin‐Binding Properties of Densely Glycosylated Clusters on a Cubic Platform
Authors: Marra Alberto , Staderini Samuele , Berthet Nathalie , Dumy Pascal , Renaudet Olivier , Dondoni Alessandro 
Published: January 2013

AbstractA new polyhedral oligomeric silsesquioxane (POSS) derivative with a periphery of eight PEGylated chains functionalized with terminal propargyl groups was synthesized starting from commercially available octavinyl‐POSS. The photoinduced free‐radical coupling of this octapropargyl POSS derivative with various sugar thiols enabled the preparation of globular hexadecavalent glycoclusters. Thus, it appears that according to the alkyne hydrothiolation mechanism, two thiyl radicals were added across each triple bond of the POSS scaffold side‐chains. The affinities of some of the densely glycosylated clusters towards certain lectins were measured by the Enzyme‐Linked Lectin Assay (ELLA). The binding selectivity of Concanavalin A between the hexadecavalent mannosylated and glucosylated clusters was much higher than the selectivity observed for the corresponding octavalent glycoclusters (ref.4). Moreover, the affinity of the N‐acetylglucosamine‐based cluster towards wheat germ agglutinin (WGA) revealed a remarkable glycoside cluster effect with up to a 9.0 × 105‐fold increase in binding compared to monovalent GlcNAc. As a multivalent effect of the same order of magnitude was reported for an octavalent GlcNAc cluster towards the same lectin (ref.4), it is concluded that increasing the number of sugar units around the cubic platform does not lead systematically to an enhancement of binding affinity.
Association of tattooing and hepatitis C virus infection: A multicenter case-control study
Authors: Carney Kerrilynn , Dhalla Sameer , Aytaman Ayse , Tenner Craig T. , Francois Fritz 
Published: January 2013

Abstract

Although injection drug use (IDU) and blood transfusions prior to 1992 are well-accepted risk factors for hepatitis C virus (HCV) infection, many studies that evaluated tattooing as a risk factor for HCV infection did not control for a history of IDU or transfusion prior to 1992. In this large, multicenter, case-control study, we analyzed demographic and HCV risk factor exposure history data from 3,871 patients, including 1,930 with chronic HCV infection (HCV RNA–positive) and 1,941 HCV-negative (HCV antibody–negative) controls. Crude and fully adjusted odds ratios (ORs) of tattoo exposure by multivariate logistic regression in HCV-infected versus controls were determined. As expected, IDU (65.9% versus 17.8%;

P

< 0.001), blood transfusion prior to 1992 (22.3% versus 11.1%;

P

< 0.001), and history of having one or more tattoos (OR, 3.81; 95% CI, 3.23-4.49;

P

< 0.001) were more common in HCV-infected patients than in control subjects. After excluding all patients with a history of ever injecting drugs and those who had a blood transfusion prior to 1992, a total of 1,886 subjects remained for analysis (465 HCV-positive patients and 1,421 controls). Among these individuals without traditional risk factors, HCV-positive patients remained significantly more likely to have a history of one or more tattoos after adjustment for age, sex, and race/ethnicity (OR, 5.17; 95% CI, 3.75-7.11;

P

< 0.001).

Conclusion:

Tattooing is associated with HCV infection, even among those without traditional HCV risk factors such as IDU and blood transfusion prior to 1992.
αB-crystallin complexes with 14-3-3ζ to induce epithelial-mesenchymal transition and resistance to sorafenib in hepatocellular carcinoma
Authors: Huang Xiao-Yong , Ke Ai-Wu , Shi Guo-Ming , Zhang Xin , Zhang Chi , Shi Ying-Hong , Wang Xiao-Ying , Ding Zhen-Bin , Xiao Yong-Sheng , Yan Jun , Qiu Shuang-Jian , Fan Jia , Zhou Jian 
Published: January 2013

Abstract

The overall survival of patients with hepatocellular carcinoma (HCC) remains poor, and the molecular pathogenesis remains incompletely defined in HCC. Here we report that increased expression of αB-Crystallin in human HCC predicts poor survival and disease recurrence after surgery. Multivariate analysis identifies αB-Crystallin expression as an independent predictor for postoperative recurrence and overall survival. We show that elevated expression of αB-Crystallin promotes HCC progression

in vivo

and

in vitro

. We demonstrate that αB-Crystallin overexpression fosters HCC progression by inducing epithelial-mesenchymal transition (EMT) in HCC cells through activation of the extracellular-regulated protein kinase (ERK) cascade, which can counteract the effect of sorafenib. αB-Crystallin complexes with and elevates 14-3-3ζ protein, leading to up-regulation of ERK1/2 activity. Moreover, overexpression of αB-Crystallin in HCC cells induces EMT progression through an ERK1/2/Fra-1/slug signaling pathway. Clinically, our data reveal that overexpression of both αB-Crystallin and 14-3-3ζ correlates with the HCC poorest survival outcomes, and sorafenib response is impaired in patients with αB-Crystallin overexpression.

Conclusion:

These data suggest that the αB-Crystallin-14-3-3ζ complex acts synergistically to promote HCC progression by constitutively activating ERK signaling. This study reveals αB-Crystallin as a potential therapeutic target for HCC and a biomarker for predicting sorafenib treatment response.
Using the nominal group technique to engage people with chronic pain in health service development
Authors: Wainwright David , Boichat Charlotte , McCracken Lance M. 
Published: January 2013

SUMMARYIn this methodological paper, we discuss the use of the nominal group technique to facilitate the involvement of people with chronic pain and other stakeholder groups in the design of a community‐based pain management programme. On the basis of our experiences of using the technique in a study conducted in the south‐west region of the UK, we explore conceptual and logistical issues relating to patient involvement in health service development, discuss political issues relating to the articulation and synthesis of different stakeholder perspectives, and provide a description of how the technique can be applied in the aforementioned context. We conclude that although the nominal group technique is not a panacea for the difficulties encountered in patient involvement, it does offer advantages over other approaches. Copyright © 2013 John Wiley & Sons, Ltd.
On the Enumeration of ‐Optimal and Minimax‐Optimal k‐Circulant Supersaturated Designs
Authors: Morales Luis B. , Vega Gerardo 
Published: January 2013

AbstractIn recent years, several methods have been proposed for constructing ‐optimal and minimax‐optimal supersaturated designs (SSDs). However, until now the enumeration problem of such designs has not been yet considered. In this paper, ‐optimal and minimax‐optimal k‐circulant SSDs with 6, 10, 14, 18, 22, and 26 runs, factors and are enumerated in a computer search. We have also enumerated all ‐optimal and minimax‐optimal k‐circulant SSDs with (mod 4) and . The computer search utilizes the fact that theses designs are equivalent to certain 1‐rotational resolvable balanced incomplete block designs. Combinatorial properties of these resolvable designs are used to restrict the search space.
Doubly Resolvable Nearly Kirkman Triple Systems
Authors: Abel R. Julian R. , Chan Nigel , Colbourn Charles J. , Lamken E. R. , Wang Chengmin , Wang Jinhua 
Published: January 2013

AbstractNecessary conditions for existence of a resolvable group divisible design (GDD) with block size 3 and type (a nearly Kirkman triple system, NKTS(v)), are and (mod 6). In this paper, we look at doubly resolvable NKTS(v)s; here we find that these necessary conditions are sufficient, except possibly for 64 values of v.
Kinetics of Carbon Dioxide Reaction with Aqueous Mixture of Piperazine and 2‐Amino‐2‐ethyl‐1,3‐propanediol
Authors: Ume Cyril Sunday , Alper Erdogan , Gordesli F. Pinar 
Published: January 2013

AbstractCurrent researchers from environmental and industrial fields are focusing on advanced means of carbon dioxide (CO2) capture to limit its consequences in process industries. They also intend to enhance the mitigation of environmental impart by CO2 especially its greenhouse effect. In this study, the kinetics of CO2 reaction with an aqueous blend of piperazine (PZ) and 2‐amino‐2‐ethyl‐1,3‐propanediol (AEPD) were investigated. It was found that blending of AEPD with a little percentage of PZ generated the observed rate constant, ko, values that were more than twice the direct summation of the ko values of the aqueous pure amines at the corresponding concentration and temperature. The kinetic study of the system was modeled using a termolecular mechanism. Blending 0.05 kmol/m3 of PZ with 0.5 kmol/m3 of AEPD gives an observed rate constant ko value of 2397.9 s−1 at 298 K. This result is comparable to rate constants of other amine mixtures. Thus, the aqueous blend of AEPD with PZ is an attractive solvent for CO2 capture that has good advantages. The PZ that serves as the promoter in the reaction is needed in small fraction, whereas AEPD, which is a sterically hindered amine, increases CO2 absorption capacity of the system. AEPD can be produced from renewable materials. © 2013 Wiley Periodicals, Inc. Int J Chem Kinet 45: 161–167, 2013
Skin graft survival on subcutaneous hinge flaps: An algorithm for nasal reconstruction
Authors: Almeyda Robert , van der Eerden Paul , Vuyk Hade 
Published: January 2013

AbstractObjectives/Hypothesis:To assess the survival of full‐thickness skin grafts and perichondrial cutaneous grafts when placed on subcutaneous soft tissue flaps used in nasal reconstruction.Study Design:Retrospective case series from a secondary‐care cutaneous cancer practice.Methods:Twenty‐eight patients with nasal defects secondary to basal cell carcinoma excision were included. Clinical information, including case notes and photography, was obtained and analyzed. Graft survival was assessed in relation to type of graft and subcutaneous soft tissue flap employed for the reconstruction.Results:Overall graft survival was 79%, with 89% and 74% for perichondrial cutaneous graft and full‐thickness skin grafts, respectively. Anecdotally, procerus and nasalis flaps were found to yield higher graft survival than cheek fat flaps.Conclusions:The combination of subcutaneous soft tissue flap and skin graft cover offers a valuable addition to the treatment algorithm for nasal reconstruction following cutaneous malignancy excision. Laryngoscope, 2013
Laser Structuring of Flexible Organic Solar Cells
Authors: Gebhardt Mandy , Hänel Jens , Allenstein Frank , Scholz Christian , Clair Maurice 
Published: January 2013

AbstractBesides the „classical”︁ inorganic solar cells based on silicon, research on novel solar cell technologies has been intensified in the last years. The focus has been put especially on organic solar cells (OPV). Their industrial production has been made possible only recently.Organic solar cells constitute an alternative to common mono‐ and polycrystalline solar cells as well as the novel thin‐film technologies. Silicon, CIS/CIGS (Copper‐Indium‐Gallium‐Selenide) and Cadmium Telluride (CdTe) are used as semiconductor materials for the last‐mentioned technology, which are largely made up of heavy metals. Highly poisonous and environmentally harmful chemicals are often involved in the production which requires large amounts of energy.
Solutions for Beam Shaping
Authors: Laskin Alexander 
Published: January 2013

AbstractGrowing popularity of high power lasers in material processing is accompanied with variety of demands to control the laser intensity profile and spot shape. The applications like metal or plastics welding, cladding, selective laser melting, hardening, brazing, annealing get benefits from providing flattop or inverse‐Gauss intensity distribution of a laser spot with round, elliptical or linear shape. The complexity of requirements is also increased due to variety of laser sources: solid‐state, diode or fiber lasers can be TEM00 or multimode, free space or fiber‐coupled, CW or pulsed, the laser power spans from few watts to several kW. To meet these requirements the up‐to‐date beam shaping solutions can be built on the base of the field mapping refractive beam shapers like πShaper, which operational principle implies transformation of laser intensity distribution from Gaussian to flattop, super‐Gauss, or inverse‐Gauss, conserving of beam consistency, low divergence of collimated output beam, high transmittance, extended depth of field, capability to operate with TEM00 or multimode lasers, implementations as telescopes or collimators. This article describes basic principles and important features of refractive beam shapers as well as some optical layouts that can be built on their base to meet requirements of modern laser technologies.
Agreement between patients' self‐report and medical records for vaccination: the PGRx database
Authors: Grimaldi‐Bensouda Lamiae , Aubrun Elodie , Leighton Pamela , Benichou Jacques , Rossignol Michel , Abenhaim Lucien ,   the PGRx Study Group
Published: January 2013

ABSTRACTPurposePatients' self‐reported vaccine exposure (PS) may be subject to memory errors and other biases. Physicians' prescription records and other medical records (MR) do not capture noncompliance with vaccination. This study compared PS with MR for influenza, 23‐valent pneumococcal, and human papillomavirus (HPV) vaccines.MethodsThe Pharmacoepidemiologic General Research Extension (PGRx) database uses a network of over 300 general practitioners across France, who systematically recruit an age‐ and sex‐stratified sample of patients (≥ 14 years old), without reference to their diagnoses or prescriptions. Patients received a structured telephone interview, combined with an interview guide listing vaccines commonly given. Patients' self‐reported vaccination in the 3 years before their recruitment was compared with medical records kept by the physician or the patient.ResultsConcordance between PS and MR was assessed for 7613 patients for whom both sources of information were available. Agreement within 3 years before the recruitment date was substantial for influenza vaccines (prevalence and bias‐adjusted kappa [PABAK] = 0.74, sensitivity PS relative to MR 81.5%) and high for 23‐valent pneumococcal vaccines (PABAK = 0.98, sensitivity PS 49.6) and HPV vaccines (PABAK = 0.92, sensitivity PS 91.6). In adjusted analyses, agreement varied with sociodemographic and health‐related factors, particularly for influenza and 23‐valent pneumococcal vaccines.ConclusionsThe PGRx method for drug exposure assessment is a new tool in pharmacoepidemiology that shows substantial to high agreement between PS and MR for exposure to various vaccines. Our finding of high agreement between PS and MR for HPV vaccination status in young women is a significant addition to the literature. Copyright © 2013 John Wiley & Sons, Ltd.
One‐pot synthesis of precise polyisoxazoles by click polymerization: Copper (I)‐catalyzed 1,3‐dipolar cycloaddition of nitrile oxides with alkynes
Authors: Li Yan , Cheng Bin 
Published: January 2013

AbstractThis article reports a new one‐pot method for polymer preparation, which involves double click chemistry. In one pot, two click reactions take place sequentially by adding the reactants step by step. The first click reaction is to produce the monomer for the second click reaction for polymerization. The click polymerization differs from the general click polymerization with the reaction of diazides and dialkynes. Nitrile oxides, produced in situ by the first click reaction of the formation of aldoxime, instead azides, avoiding the poisonousness and explosiveness of azides and being much safer and easy to operate. And 3,5‐disubstitute polyisoxazoles are produced by the copper(I)‐catalyzed the 1,3‐dipolar cycloaddition of nitrile oxides with alkynes in high yields by our one‐pot method. The resulting polyisoxazoles agree well with the structural assignment obtained by the 1H NMR and IR analyses, with high molecular weights, narrow molecular weight distribution (Mw/Mn < 1.2) and high regioregularity. The poor solubility of these polymers is found to be caused by their crystallization. Improvement of solubility is achieved by modifying the structures of alkyne monomers. All the polymers are thermally stable, losing little of their weights when heated to ∼350 °C. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Synthesis of well‐defined comb‐like graft (co)polymers by nucleophilic substitution reaction between living polymers and polyhalohydrocarbon
Authors: Lin Yichao , Zheng Jun , Liu Feng , Tang Tao 
Published: January 2013

AbstractA series of graft (co)polymers were synthesized by nucleophilic substitution reaction between iodinated 1,2‐polybutadiene (PB‐I, backbone) and living polymer lithium (side chains). The coupling reaction between PB‐I and living polymers can finish within minutes at room temperature, and high conversion (up to 92%) could be obtained by effectively avoiding side reaction of dimerization when living polymers were capped with 1,1‐diphenylethylene. By virtue of living anionic polymerization, backbone length, side chain length, and side chain composition, as well as graft density, were well controlled. Tunable molecular weight of graft (co)polymers with narrow molecular weight distribution can be obtained by changing either the lengths of side chain and backbone, or the graft density. Graft copolymers could also be synthesized with side chains of multicomponent polymers, such as block polymer (polystyrene‐b‐polybutadiene) and even mixed polymers (polystyrene and polybutadiene) as hetero chains. Thus, based on living anionic polymerization, this work provides a facile way for modular synthesis of graft (co)polymers via nucleophilic substitution reaction between living polymers and polyhalohydrocarbon (PB‐I). © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Phase separation at the magnetic–superconducting transition in La0.7Y0.3FeAsO1−xFx
Authors: Prando Giacomo , Sanna Samuele , Lamura Gianrico , Shiroka Toni , Tropeano Matteo , Palenzona Andrea , Grafe Hans‐Joachim , Büchner Bernd , Carretta Pietro , De Renzi Roberto 
Published: January 2013

AbstractIn this paper we report a detailed µ+SR and 19F NMR study of the La0.7Y0.3FeAsO1−xFx class of materials. Here, the diamagnetic La1−yYy substitution increases chemical pressure and, accordingly, sizeably enhances the optimal superconducting transition temperature. We investigate the magnetic–superconducting phase transition by keeping the Y content constant (y = 0.3) and by varying the F content in the range $0.025\leq x\leq 0.15$. Our results show how magnetism and superconductivity coexist for x = 0.065. Such coexistence is due to segregation of the two phases in macroscopic regions, resembling what was observed in LaFeAsO1−xFx materials under applied hydrostatic pressure. This scenario is qualitatively different from the nanoscopic coexistence of the two order parameters observed when La is fully substituted by magnetic rare‐earth ions like Sm or Ce.
Seebeck effect near quantum MIT in Eu1 − xCaxB6
Authors: Glushkov Vladimir , Baybakov Ruslan , Demishev Sergey , Dukhnenko Anatoliy , Levchenko Anna , Shitsevalova Natalya , Sluchanko Nickolay 
Published: January 2013

AbstractWe report the results of a Seebeck effect study carried out on the single crystals of Eu1 − xCaxB6 (0 ≤ x ≤ 1) at temperatures 1.8–300 K. The Seebeck coefficient is shown to be determined by the sum of the linear term S = AT and a phonon‐drag contribution, which is induced by the local phonon mode of europium (calcium) with the characteristic frequency 7.3 meV (9.1 meV). The crossover from negative (A ≈ −0.23 µV K−2 for x = 0) to positive (A ≈ +1.2 µV K−2 for x = 0.244) values of the diffusion thermopower indicates the smooth change of the band structure when approaching the hole‐like conductivity found in Eu1 − xCaxB6 at x > xC ≈ 0.2.
Indications of a magnetic‐field‐driven anisotropy in the hybridization gap semiconductor CeOs4As12
Authors: Cichorek Tomasz , Bochenek Lukasz , Wawryk Ryszard , Henkie Zygmunt 
Published: January 2013

AbstractThe filled skutterudite compound CeOs4As12 displays phenomena that are associated with hybridization between the 4f‐electron and conduction‐electron states. This holds especially true for a semiconducting ground state with a main energy gap as small as Δ/kB = 45 K. When subjected to magnetic field, the hybridization gap semiconductor CeOs4As12 becomes metallic below around 2.5 K. Preliminary electrical‐resistivity experiments provide evidence for an anisotropy of magnetic‐field‐induced insulator–metal transition in this cubic material. Our findings suggest a contribution of the quartet $4{\rm f \hbox{-} }\Gamma _{67}^{- } $ states to transport properties of CeOs4As12.
Adaptive neural network control of bilateral teleoperation with unsymmetrical stochastic delays and unmodeled dynamics
Authors: Li Zhijun , Xia Yuanqing 
Published: January 2013

SUMMARYIn this paper, adaptive NN control is proposed for bilateral teleoperation system with dynamic uncertainties, unknown external disturbances, and unsymmetrical stochastic delays in communication channel to achieve transparency and robust stability. Compared with previous passivity‐based teleoperation framework, the communication delays are unsymmetrical and stochastic. By partial feedback linearization using nominal dynamics, the nonlinear dynamics of the teleoperation system are transformed into two subsystems: local master/slave dynamics control and time‐delay motion tracking. By integrating Markov jump systems and adaptive parameters updating, adaptive NN control strategy is developed. The stability of the closed‐loop system and the boundedness of tracking errors are proved using Lyapunov–Krasovskii functional synthesis under specific linear matrix inequalities conditions. The proposed adaptive NN control is robust against motion disturbances, parametric uncertainties, and unsymmetrical stochastic delay, which effectiveness is validated by extensive simulation studies. Copyright © 2013 John Wiley & Sons, Ltd.
Direct air capture of CO2 with chemicals: optimization of a two-loop hydroxide carbonate system using a countercurrent air-liquid contactor
Authors: Mazzotti Marco , Baciocchi Renato , Desmond Michael J. , Socolow Robert H. 
Published: January 2013

Abstract
Direct Air Capture (DAC) of CO2 with chemicals, recently assessed in a dedicated study by the American Physical Society (APS), is further investigated with the aim of optimizing the design of the front-end section of its benchmark two-loop hydroxide-carbonate system. Two new correlations are developed that relate mass transfer and pressure drop to the air and liquid flow velocities in the countercurrent packed absorption column. These relationships enable an optimization to be performed over the parameters of the air contactor, specifically the velocities of air and liquid sorbent and the fraction of CO2 captured. Three structured Sulzer packings are considered: Mellapak-250Y, Mellapak-500Y, and Mellapak-CC. These differ in cost and pressure drop per unit length; Mellapak-CC is new and specifically designed for CO2 capture. Scaling laws are developed to estimate the costs of the alternative DAC systems relative to the APS benchmark, for plants capturing 1 Mt of CO2 per year from ambient air at 500 ppm CO2 concentration. The optimized avoided cost hardly differs across the three packing materials, ranging from $518/tCO2 for M-CC to $568/tCO2 for M-250Y. The $610/tCO2 avoided cost for the APS-DAC design used M-250 Y but was not optimized; thus, optimization with the same packing lowered the avoided cost of the APS system by 7 % and improved packing lowered the avoided cost by a further 9 % The overall optimization exercise confirms that capture from air with the APS benchmark system or systems with comparable avoided costs is not a competitive mitigation strategy as long as the energy system contains high-carbon power, since implementation of Carbon Capture and Storage, substitution with low-carbon power and end-use efficiency will offer lower avoided-cost strategies.