bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fabrication of tetra‐n‐butylammonium hydrogen sulfate‐based poly(lactic acid)‐poly(ethylene glycol) composite electrospun wound dressing
Authors: Şener Sena Özdil , Yilmaz Sema Samatya , Doganci Merve Dandan , Doganci Erdinc 
Published: August 2024

AbstractIn this study, poly(lactic acid)‐poly(ethylene glycol)‐tetra‐n‐butylammonium hydrogen sulfate (PLA‐PEG‐HS) electrospun mats were fabricated by electrospinning as effective wound dressings against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), which are the most prevalent species of gram‐positive and gram‐negative bacteria, respectively. PLA is a polymer with high biocompatibility and biodegradability, but its structure is fragile. Therefore, we aimed to improve its structural properties using PEG as a plasticizer and to provide antibacterial properties with HS salt. The nanofibers characterized using differential scanning calorimetry (DSC), Fourier transform infrared (FTIR) spectroscopy, thermal gravimetric analysis (TGA), and drying time tests. The addition of HS eliminated the beads in the PLA‐PEG nanofiber and improved the homogeneity of the fiber distribution. Concerning this result, when the liquid absorption capacity (LAC) test was evaluated, PLA‐PEG‐HS nanofiber production was achieved with the highest rate of 480.95%. The thermal properties of nanofibers increased with the addition of HS. Cytotoxicity test results of PLA‐PEG‐HS wound dressings showed high cell viability of 129.05% in L292 mouse fibroblast cells at the end of the 24th hour. PLA‐PEG‐HS nanofibers with 99.99% antibacterial activity against tow bacteria. Considering the modern wound dressing requirements, antibacterial wound dressing production has been successfully achieved.
Carbon black dispersing agents based on fully hydrophilic poly(N‐vinylamide): Surface adsorption via selective interactions
Authors: Jeschenko Pascal M. , Köhler Jens , Lantzius‐Beninga Marcus , Möller Martin 
Published: August 2024

AbstractInterface‐stabilizing polymers are frequently used in commercial applications to provide long‐lasting dispersions of colloids in liquid media. Dispersing high concentrations of pigments in aqueous solution can be particularly challenging. Here, we present a novel, fully hydrophilic dispersing agent system for carbon black (CB) pigments based on partially hydrolyzed poly(N‐vinylamides). These highly water‐soluble polymers adsorb onto CB through specific interactions between the polymer and surface‐bound moieties, rather than the hydrophobic effect. They participate in hydrogen bonding, ion–dipole interactions and can be partially positively charged to engage in ion pair formation, providing strong surface affinity. Dispersants are synthesized using free radical copolymerization of N‐vinylform‐ and ‐acetamide, acidic hydrolysis, and subsequent PEGylation. Molecular water solubility of the synthesized polymers is confirmed by using fluorescence spectroscopy. Highly concentrated CB dispersions are prepared in acidic, neutral, and basic media, which we identify to strongly affect the interactions between polymer and CB. The stability of CB dispersions is analyzed using ultracentrifugation and thermogravimetric analysis. The presented polymers are able to provide significantly more stable dispersions than a commercial reference product, showcasing the suitability of poly(N‐vinylamines) as potent CB dispersing agents.
3D Printing MXene‐Based Electrodes for Supercapacitors
Authors: Jiang Xudong , Bai Juan , Wijerathne Binodhya , Zhou Qianqin , Zhang Fan , Liao Ting , Sun Ziqi 
Published: August 2024

Abstract3D printing, as an advanced and promising strategy for processing electrode for energy storage devices, such as supercapacitors and batteries, has garnered considerable interest in recent decades. The interest in 3D printed electrodes stems from its exceptional performance and manufacturing features, including customized sizes and shapes and the layer‐by‐layer processing principle, etc., especially integrating with MXene which allows the manufacturing of electrodes from different raw materials and possessing desired electrochemical properties. Herculean challenges, such as material compatibility of the printing inks, nondurable interfacial or bulk mechanical strength of the printed electrodes, and sometimes the low capacitance, lead to inferior electrochemical performance and hinder the practical applications of this promising technology. In this review, we firstly summarize the representative 3D printing methods, then, review the MXene‐based 3D printing electrodes made from different materials, and last, provide electrochemical performance of 3D printing MXene‐based electrodes for supercapacitors. Furthermore, based on a summary on the recent progress, an outlook on these promising electrodes for sustainable energy devices is provided. We anticipate that this review could provide some insights into overcoming the challenges and achieving more remarkable electrochemical performance of 3D printing supercapacitor electrodes and offer perspectives in the future for emerging energy devices.
Bifunctional Nitrogen‐Rich Heterocyclic Compounds: Synthesis, Photoluminescence and Energetic Properties
Authors: Zeng Zhiwei , Yang Xiaoxiao , Huang Qiaoyi , Tang Mingjie , Liu Yuji , Huang Wei , Xu Bo , Tang Yongxing 
Published: August 2024

AbstractNitrogen‐rich heterocyclic frameworks have attracted enormous interest in organic chemistry and materials science. However, their potential for developing photoluminescent materials remains underexplored due to their relatively low molecular stabilities. In this work, two tricyclic fused nitrogen‐rich fluorescent heterocycles were synthesized and characterized. The photophysical properties of the synthesized 4 and 5 were investigated through theoretical and experimental studies. In addition, their physicochemical and energetic properties and the performance as an additive to the perovskite absorption layer of the perovskite solar cell were also studied.
Can sustainable and digital objectives synchronize? A study of ESG activities for digital supply chains using multi‐methods
Authors: Singh Arpit , Dwivedi Ashish , Agrawal Dindayal , Bag Surajit , Chauhan Anurag 
Published: August 2024

AbstractIn both private and Government sectors, the convergence of digital technologies and environmental, social, and governance assessment addresses concerns regarding sustainable practices. This study explores crucial ESG activities for sustainable digital supply chain focusing on their promotion of sustainable businesses. Initially, a literature review and experts input identified 12 potential activities. Using the Best‐Worst Method, these activities were ranked, and their interactions were evaluated through Total Interpretive Structural Modeling and the Matrix of Cross‐Impact Multiplication Applied to Classification technique. The key activities identified include “circular economy practices and waste reduction,” “energy efficiency and reduction in carbon emissions,” and “data privacy and cybersecurity.” Understanding these activities enables organizations to mitigate environmental impact, enhance social performance, and improve governance practices in supply chains. The implications extend to fostering environmentally conscious supply chains in a rapidly evolving digital landscape, aligning with “sustainable development goals,” including justice, responsible consumption, clean energy, and climate action.
UGT1A1*28 polymorphism and the risk of toxicity and disease progression in patients with breast cancer receiving sacituzumab govitecan
Authors: Wong Megan H. , Jones Veronica C. , Yu Wai , Bosserman Linda D. , Lavasani Sayeh M. , Patel Niki , Sedrak Mina S. , Stewart Daphne B. , Waisman James R. , Yuan Yuan , Mortimer Joanne E. 
Published: August 2024

AbstractBackgroundSacituzumab govitecan (sacituzumab) emerged as an important agent in metastatic and locally recurrent HER2‐negative breast cancer treatment. UGT1A1 polymorphisms have also been shown to predict sacituzumab toxicity.MethodsIn this retrospective study, we sought to evaluate the associations between UGT1A1 status, toxicity, and therapeutic outcomes in sacituzumab recipients with advanced breast cancer who underwent genotype testing for UGT1A1 alleles (N = 68).ResultsWe found 17 (25%) of our patients to be homozygous for UGT1A1*28 and 24 (35.3%) were heterozygous. Of seven African American patients with triple‐negative breast cancer, five were homozygous for UGT1A1*28 and two were heterozygous. Patients with a homozygous UGT1A1*28 genotype were significantly more likely to have treatment terminated because of adverse effects. However, the polymorphism was not associated with treatment discontinuation because of disease progression.ConclusionThis retrospective, real‐world analysis suggests potential clinical utility in UGT1A1 testing for patients receiving sacituzumab, but future trials are needed to confirm the association between genotypes and treatment outcomes.
Main chemical constituents and mechanism of anti‐tumor action of Solanum nigrum L
Authors: Zhao Zhen‐duo , Hu Cheng , Li Ling , Zhang Jia‐qi , Zhang Li‐chao 
Published: August 2024

AbstractObjectiveSolanum nigrum L. (SNL) is a natural drugwith diverse bioactive components and multi‐targeted anti‐tumor effects, gaining increasing attention in clinical application.Method and ResultsThis paper reviews the studies on SNL by searching academic databases (Google Scholar, PubMed, Science Direct,and Web of Science, among others), analyzing its chemical compositions (alkaloids, saponins, polysaccharides, and polyphenols, among others), andbriefly describes the anti‐tumor mechanisms of the main components.DiscussionThis paper discusses the shortcomings of the current research on SNL and proposes corresponding solutions, providing theoretical support for further research on its biological functions and clinical efficacy.
Intraoperative radiotherapy: An alternative to whole‐breast external beam radiotherapy in the management of highly selective breast cancer: A SEER database analysis
Authors: Sun Dexun , Lu Guanhua , Liang Fenmei , Zhang Wangjian , Zeng Tao , Ling Yun , Peng Haojie , Xia Ting , Hu Meilin , Chen Xinxin 
Published: August 2024

AbstractObjectiveThis study aimed to verify if intraoperative radiotherapy (IORT) can achieve the same survival outcome as whole‐breast external beam radiotherapy (EBRT) in early breast cancer after breast‐conserving surgery (BCS), and to explore the suitable candidates that can safely receive IORT after BCS.MethodsEligible post‐BCS patients who received IORT or EBRT were included in the Surveillance, Epidemiology and End Results (SEER) database from 2010 to 2018. Risk factors that affected 5‐year overall survival (OS) or breast cancer specific survival (BCSS) were identified by Cox proportional hazards regression analysis. Clinical characteristics, OS, and BCSS were comparatively analyzed between the two treatment modalities.ResultsThe survival analysis after propensity score matching confirmed that patients who received IORT (n = 2200) had a better 5‐year OS than those who received EBRT (n = 2200) (p = 0.015). However, the two groups did not differ significantly in 5‐year BCSS (p = 0.381). This feature persisted even after multivariate analyses that took into account numerous clinical characteristics. Although there was no significant difference in BCSS between different subgroups of patients treated with IORT or EBRT, patients over 55 years of age, with T1, N0, non‐triple negative breast cancers, hormone receptor‐positive, and histologic grade II showed a better OS after receiving IORT.ConclusionIn low‐risk, early‐stage breast cancer, IORT was not inferior to EBRT considering 5‐year BCSS and OS. Considering the equivalent clinical outcome but less radiotoxicity, IORT might be a reasonable alternative to EBRT in highly selective patients undergoing BCS.
Negative pressure wound therapy for extensive soft tissue defects of the lower extremity in a teenager: A case study
Authors: Stanek Rainer , Pointner Eva‐Maria , de Cerchi Katja Canigiani , Pomberger Gerhard , Benkoe Thomas , Hölzenbein Thomas , Mousavi Mehdi 
Published: August 2024

Key Clinical MessageNegative pressure wound therapy (NPWT) aided in the management of complex soft tissue injury in a 14‐year‐old girl by managing moisture, reducing oedema, and stimulating wound granulation less than 2 months after the accident and prepared the skin for skin grafting, thus successfully saving the limb.AbstractThis case study describes the use of a tubular bandage encompassing the whole limb to deliver successful NPWT in the treatment and reconstruction of extensive soft tissue damage extending from the right lower extremity to the hip in a 14‐year‐old female.
Intra‐flap recurrence of an oral squamous cell carcinoma after curative resection and reconstruction with a free flap
Authors: Liokatis Paris , Liokati Ioanna , Fegg Florian Nepomuk , Dewenter Ina , Mast Gerson , Otto Sven , Obermeier Katharina Theresa 
Published: August 2024

Key Clinical MessageIntra‐flap recurrence after reconstruction is a possible complication in oral squamous cell carcinoma (OSCC) after curative resection and reconstruction with a free flap.AbstractThis case report describes an intra‐flap recurrence after tumor resection and reconstruction with a latissimus dorsi flap due to OSCC. We report a 58‐year‐old female patient who underwent curative resection of a squamous cell carcinoma in the oral cavity and submental area and reconstruction with a latissimus dorsi free flap. Thirteen months after the operation, the patient presented with lung metastases and, 22 months after the operation, a metastatic lesion in the flap's central area with no sign of recurrence in the primary resection site occurred. The patient died 25 months after the initial operation due to the rapid progression of the disease and further distant metastases. To our knowledge, similar cases do not exist in the literature. This is the first reported case of intra‐flap metastasis after surgical treatment of OSCC.
Early onset of posterior reversible encephalopathy syndrome (PRES) following postpartum eclampsia—A case report
Authors: ullah Kaleem , Shah Hussain Haider , Tariq Maryam , Oduoye Malik Olatunde 
Published: August 2024

Key Clinical MessageEarly screening and management of postpartum posterior reversible encephalopathy syndrome (PRES) can reduce hospital stay and complications. Obstetricians, gynecologists, ophthalmologists, and even general physicians should be aware of PRES since its presentation is variable.
Strategies and Applications for Supramolecular Protein Self‐Assembly
Authors: Li Yijia , Tian Ruizhen , Zou Yingping , Wang Tingting , Liu Junqiu 
Published: August 2024

AbstractSupramolecular chemistry achieves higher‐order molecular self‐assembly through non‐covalent interactions. Utilizing supramolecular methods to explore the polymorphism of proteins, the building blocks of life, from a “bottom‐up” perspective is essential for constructing diverse and functional biomaterials. In recent years, significant progress has been achieved in the design strategies and functional applications of supramolecular protein self‐assembly, becoming a focal point for researchers. This paper reviews classical supramolecular strategies driving protein self‐assembly, including electrostatic interactions, metal coordination, hydrogen bonding, hydrophobic interactions, host‐guest interactions, and other mechanisms. We discuss how these supramolecular interactions regulate protein assembly processes and highlight protein supramolecular assemblies′ unique structural and functional advantages in constructing artificial photosynthetic systems, protein hydrogels, bio‐delivery systems, and other functional materials. The enormous potential and significance of supramolecular protein materials are elucidated. Finally, the challenges in preparing and applying protein supramolecular assemblies are summarized, and future development directions are projected.
Non‐Medical Applications of Inorganic Medicines. A Switch Based on Mechanistic Knowledge
Authors: Cirri Damiano , Di Leo Riccardo , Chiaverini Lorenzo , Tolbatov Iogann , Marrone Alessandro , Messori Luigi , Pratesi Alessandro , La Mendola Diego , Marzo Tiziano 
Published: August 2024

AbstractMetals have been used in medicine for centuries. However, it was not until much later that the effects of inorganic drugs could be rationalized from a mechanistic point of view. Today, thanks to the technologies available, this approach has been functionally developed and implemented. It has been found that there is probably no single biological target for the pharmacological effects of most inorganic drugs. Herein, we present an overview of some integrated and multi‐technique approaches to elucidate the molecular interactions underlying the biological effects of metallodrugs. On this premise, selected examples are used to illustrate how the information obtained on metal‐based drugs and their respective mechanisms can become relevant for applications in fields other than medicine. For example, some well‐known metallodrugs, which have been shown to bind specific amino acid residues of proteins, can be used to solve problems related to protein structure elucidation in crystallographic studies. Diruthenium tetraacetate can be used to catalyze the conversion of hydroxylamines to nitrones with a high selectivity when bound to lysozyme. Finally, a case study is presented in which an unprecedented palladium/arsenic‐mediated catalytic cycle for nitrile hydration was discovered thanks to previous studies on the solution chemistry of the anticancer compound arsenoplatin‐1 (AP‐1).
Visible‐Light‐Driven Method for the Selective Synthesis of Amides and N‐Acylureas from Carboxylic Acids and Thioureas
Authors: Zhong Pinyong , Yang Min , Liu Kunming , He Weimin , Liu Jin‐Biao 
Published: August 2024

AbstractIn this work, we developed a visible‐light‐driven method for the selective synthesis of amides and N‐acylureas from carboxylic acids and thioureas. This protocol was featured as avoidance of additional oxidants and transition metal catalysts, simple manipulations, low cost, broad substrate scope, and good functional group tolerance. As only oxygen serves as the oxidation reagent, this method provides a promising synthesis candidate for the formation of N‐aryl amides and N‐acylureas, including late‐stage functionalization of complex pharmaceutical molecules and biologically active molecules.
Facile Method to Obtain Functionalised η6‐Bound Arenes in Ru(II) and Os(II) Half‐Sandwich Complexes
Authors: Cardozo Claudia , Pizarro Ana M. 
Published: August 2024

AbstractHalf‐sandwich Ru(II)‐ and Os(II)‐arene complexes have great potential for catalytic and biological applications. The possibility of fine‐tuning their chemical reactivity by including modifications in the ligands around the metal adds to their many advantages. However, structural modifications at the η6‐bound arene have had significant synthetic limitations, particularly in the design of Os(II)‐tethered complexes. For the first time, we have employed a practical C(sp3)‐C(sp2) coupling to obtain 28 new Ru(II) and Os(II) η6‐arene half‐sandwich complexes with a wide variety of arene functionalities, including those that enable the formation of tether rings, such as quinoline, and coumarin. The introduction of novel functional groups at the arene in Ru(II)‐ and Os(II) half‐sandwich complexes can broaden the synthetic scope of this type of organometallic complexes, and help to take full advantage of their structural diversity, for example, in intracellular catalysis.
Chemical Membrane Reactors
Authors: Caro Jürgen 
Published: August 2024

AbstractChemical membrane reactors combine a chemical reaction with an in‐situ removal/import of products/educts through a permselective membrane. The corresponding reactors are named extractor‐type or distributor‐type membrane reactors. Three recent examples for boosting a chemical reaction in an extractor‐type membrane reactor with water‐selective zeolite membranes and three examples for distributor‐type membrane reactors with oxygen‐selective ceramic membranes will be discussed.
Two Step One‐Pot Synthesis of 7‐Azaindole Linked 1,2,3‐Triazole Hybrids: In‐Vitro and In‐Silico Antimicrobial Evaluation
Authors: Sharma Kanika , Lal Bajrang , Kumar Tittal Ram , Lal Kashmiri , Vats Lalit , Vikas D Ghule 
Published: August 2024

AbstractHerein, we report design, synthesis and characterization of a new library of 7‐azaindole N‐ethyl linked 1,2,3‐triazoles containing ethylene as a spacer unit, and evaluation of all the synthesized compounds for their antimicrobial properties. Antibacterial potential was checked against two Gram positive (B. subtilis and S. aureus) and two Gram negative (E. coli and P. aeruginosa) bacterial strains while antifungal potential was assayed against two fungal strains (C. albicans and A. niger). All the tested compounds showed satisfactory antibacterial potency in comparison to reference drug ciprofloxacin with MIC values ranging from 0.0108 to 0.0432 μmol/mL. Interestingly, except two, all the target compounds showed better antifungal property as compared to the reference drug fluconazole with MIC values less than 0.0408 μmol/mL. One of the compounds exhibited two‐fold better antifungal potential in comparison to fluconazole. Furthermore, in‐silico ADMET and DFT studies reported drug likeness behavior and chemical reactivity parameters, respectively. The cytotoxicity results on substrate azide 3 and most potent 1,2,3‐triazoles (5 d and 5 l) were found to be non‐toxic.
Reduced order modelling of intracranial aneurysm flow using proper orthogonal decomposition and neural networks
Authors: MacRaild Michael , Sarrami‐Foroushani Ali , Lassila Toni , Frangi Alejandro F. 
Published: August 2024

AbstractReduced order modelling (ROMs) methods, such as proper orthogonal decomposition (POD), systematically reduce the dimensionality of high‐fidelity computational models and potentially achieve large gains in execution speed. Machine learning (ML) using neural networks has been used to overcome limitations of traditional ROM techniques when applied to nonlinear problems, which has led to the recent development of reduced order models augmented by machine learning (ML‐ROMs). However, the performance of ML‐ROMs is yet to be widely evaluated in realistic applications and questions remain regarding the optimal design of ML‐ROMs. In this study, we investigate the application of a non‐intrusive parametric ML‐ROM to a nonlinear, time‐dependent fluid dynamics problem in a complex 3D geometry. We construct the ML‐ROM using POD for dimensionality reduction and neural networks for interpolation of the ROM coefficients. We compare three different network designs in terms of approximation accuracy and performance. We test our ML‐ROM on a flow problem in intracranial aneurysms, where flow variability effects are important when evaluating rupture risk and simulating treatment outcomes. The best‐performing network design in our comparison used a two‐stage POD reduction, a technique rarely used in previous studies. The best‐performing ROM achieved mean test accuracies of 98.6% and 97.6% in the parent vessel and the aneurysm, respectively, while providing speed‐up factors of the order .