bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ferromagnetic Fiber Systems for Multiplexing Neural Recording and Modulation with Spatial Selectivity
Authors: Song Hao , Liu Yuxin , Li Jing , Liu Zijian , Yang Anqi , Lu Baicheng , Zhou Yajing , Duan Junhan , Li Jialong , He Jufang , Chen Xi , Lin Xudong 
Published: July 2024

AbstractDespite the great success achieved by recently developed neural interfaces, multi‐site monitoring and regulating neural activities with high spatial and temporal selectivity remain a challenge. Here, an implantable, remotely controllable, fiber‐based ferromagnetic system permitting 3D navigation, omnidirectional steering, multiplexing neural recording, and modulation is presented. A family of fibers is fabricated that allows for the heterogeneous integration of ferromagnetic, optical, microfluidic, electrical, and electrochemical components into the proposed multifunctional neural interface. Coupling with magnetic actuation, it is demonstrated that this system can enable optical and chemical modulation of local neural activities across multiple distant regions in rodent brains, while simultaneously allowing the real‐time monitoring of neural electrophysiological and chemical activities. Furthermore, to systematically identify altered patterns of behaviors, brain activities and dopamine release during optogenetic modulation of specific nuclei in Parkinsonian animals this platform is employed. This proposed system with high spatial selectivity, multiplexing sensing and multimodal manipulating capabilities offers a versatile platform to advance both fundamental neuroscience studies and translational applications in neurologic disease treatments.
Loofah‐Inspired Ultralight and Superelastic Micro/Nanofibrous Aerogels for Highly Efficient Thermal Insulation
Authors: Zhang Wei , Liang Guoqiang , Wang Sai , Yang Fengjin , Liu Xiaoyan , Yu Jianyong , Zhang Shichao , Ding Bin 
Published: July 2024

AbstractExtreme cold events are becoming more frequent and intense around the world, imposing a huge burden on human health and global economy. However, developing fibrous materials featuring ultralight weight, high shape retention, and high thermal insulation to withstand extreme conditions remains a great challenge. Herein, inspired by the natural porous loofah, an ultralight and superelastic micro/nanofibrous aerogel (MNFA) that integrates hierarchical pores and stable physical entanglements is directly synthesized via gelation electrospinning technology. By manipulating the solution/water molecules interaction of the charged jets, a hierarchical porous structure consisting of fibrous porous networks and aerogel microfibers is developed, which endows MNFA with high porosity (99.7%). Benefiting from the stable physical entanglement structure between the rigid microfibers and flexible nanofibers, the resulting MNFA can withstand large tensile stress (4000 times of its weight) and 1000 compression cycles without being damaged. Moreover, MNFA exhibits ultralight feature (3 mg cm−3) and high thermal insulation performance (low thermal conductivity of 25.3 mW m−1 K−1), making a promising contender for highly efficient thermal insulation. This work can offer fresh perspectives on the design and advancement of advanced fibrous aerogels for a variety of uses.
Mitoxantrone Combined with Engineered TRAIL‐Nanovesicles for Enhanced Cancer Immunotherapy Via Converting Apoptosis into Pyroptosis
Authors: Wang Yi , Niu Boning , Tian Yinmei , Lan Hongbing , Zhou Zhanhao , Li Yang , Zhao Siyu , Zhang Yu , Yang Conglian , Kong Li , Zhang Zhiping 
Published: July 2024

AbstractPyroptosis, a highly inflammatory form of programmed cell death, has emerged as a promising target for cancer immunotherapy. However, in the context of pyroptosis execution, while both caspase‐3 and GSDME are essential, it is noteworthy that GSDME is frequently under‐expressed in cold tumors. To overcome this limitation, engineered cellular nanovesicles (NVs) presenting TRAIL on their membranes (NVTRAIL) are developed to trigger the upregulation of cleaved caspase‐3. When strategically combined with the chemotherapeutic agent mitoxantrone (MTO), known for its ability to enhance GSDME expression, MTO@NVTRAIL can convert cancer cells from apoptosis into pyroptosis, inhibit the tumor growth and metastasis successfully in primary tumor. The microparticles released by pyroptotic tumor cells also exhibited certain cytotoxicity against other tumor cells. In addition, tumor cells exposed to the combination treatment of MTO@NVTRAIL in vitro have also demonstrated potential utility as a novel form of vaccine for cancer immunotherapy. Flow analysis of the tumor microenvironment and draining lymph nodes reveals an increased proportion of matured dendritic cells and activation of T cells. In summary, the research provided a reference and alternative approach to induce cancer pyroptosis for clinical antitumor therapy based on engineered cellular nanovesicles and chemotherapy.
Towards the 10‐Year Milestone of Monolithic Perovskite/Silicon Tandem Solar Cells
Authors: Ying Zhiqin , Yang Xi , Wang Xuezhen , Ye Jichun 
Published: July 2024

AbstractThe perovskite/silicon tandem solar cell represents one of the most promising avenues for exceeding the Shockley–Queisser limit for single‐junction solar cells at a reasonable cost. Remarkably, its efficiency has rapidly increased from 13.7% in 2015 to 34.6% in 2024. Despite the significant research efforts dedicated to this topic, the “secret” to achieving high‐performance perovskite/silicon tandem solar cells seems to be confined to a few research groups. Additionally, the discrepancies in preparation and characterization between single‐junction and tandem solar cells continue to impede the transition from efficient single‐junction to efficient tandem solar cells. This review first revisits the key milestones in the development of monolithic perovskite/silicon tandem solar cells over the past decade. Then, a comprehensive analysis of the background, advancements, and challenges in perovskite/silicon tandem solar cells is provided, following the sequence of the tandem fabrication process. The progress and limitations of the prevalent stability measurements for tandem devices are also discussed. Finally, a roadmap for designing efficient, scalable, and stable perovskite/silicon tandem solar cells is outlined. This review takes the growth history into consideration while charting the future course of perovskite/silicon tandem research.
Effective Prevention and Treatment of Acute Leukemias in Mice by Activation of Thermogenic Adipose Tissues
Authors: Chen Ruibo , Cheng Tianran , Xie Sisi , Sun Xiaoting , Chen Mingjia , Zhao Shumin , Ruan Qingyan , Ni Xiaolei , Rao Mei , Quan Xinyi , Chen Kaiwen , Zhang Shiyue , Cheng Tao , Xu Yuanfu , Chen Yuguo , Yang Yunlong , Cao Yihai 
Published: July 2024

AbstractAcute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) are common hematological malignancies in adults. Despite considerable research advances, the development of standard therapies, supportive care, and prognosis for the majority of AML and ALL patients remains poor and the development of new effective therapy is urgently needed. Here, it is reported that activation of thermogenic adipose tissues (TATs) by cold exposure or β3‐adrenergic receptor agonists markedly alleviated the development and progression of AML and ALL in mouse leukemia models. TAT activation (TATA) monotherapy substantially reduces leukemic cells in bone marrow and peripheral blood, and suppresses leukemic cell invasion, including hepatomegaly and splenomegaly. Notably, TATA therapy prolongs the survivals of AML‐ and ALL‐bearing mice. Surgical removal of thermogenic brown adipose tissue (BAT) or genetic deletion of uncoupling protein 1 (UCP1) largely abolishes the TATA‐mediated anti‐leukemia effects. Metabolomic pathway analysis demonstrates that glycolytic metabolism, which is essential for anabolic leukemic cell growth, is severely impaired in TATA‐treated leukemic cells. Moreover, a combination of TATA therapy with chemotherapy produces enhanced anti‐leukemic effects and reduces chemotoxicity. These data provide a new TATA‐based therapeutic paradigm for the effective treatment of AML, ALL, and likely other types of hematological malignancies.
Ni/Cu Dual‐Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital
Authors: Chang Xihao , Zhang Jiayin , Cheng Xiang , Lv Xianhai , Guo Chang 
Published: July 2024

AbstractThe development of efficient methodologies for the controlled manufacture of specific stereoisomers bearing quaternary stereocenters has prompted advances in a variety of scientific disciplines including pharmaceutical chemistry, materials science, and chemical biology. However, complete control of the absolute and relative stereochemical configurations of alkyne derivatives remains an unmet synthetic challenge. Herein, a Ni/Cu dual‐catalyzed asymmetric propargylic substitution reaction is presented to produce propargylated products with all‐carbon quaternary stereocenters in high yields with significant diastereo‐ and enantioselectivities (up to >20:1 dr, >99% ee). The synthesis of all stereochemical variants of methohexital, a widely used sedative‐hypnotic drug, exemplifies the efficacy of dual‐catalyzed stereodivergent propargylation.
The path less traveled: Using structural equation modeling to investigate factors influencing bone functional morphology
Authors: Johnston Rob'yn A. , Cowgill Libby W. 
Published: July 2024

AbstractObjectivesThe relationship between an organism's mechanical environment and its bone strength has been long established by experimental research. Multiple intrinsic and extrinsic factors, including body mass, muscle strength, genetic background, and nutritional and/or hormonal status, are likely to influence bone deposition and resorption throughout the lifespan, complicating this relationship. Structural equation modeling (SEM) is uniquely positioned to parse this complex set of influences.Materials and MethodsData from the Third National Health and Nutrition Examination Survey, including sex, total body mass, lean body mass, exercise frequency, peak body mass, and age, were analyzed using SEM to determine how they affect bone strength both individually and combined.ResultsBody mass is typically the driver of cross‐sectional area, but body mass and lean mass have similar effects on the polar moment of area (J). Peak body mass had a strong direct effect on J, despite decreasing strongly with increases in lean mass. Exercise also did not confer a large direct effect on cross‐sectional area or J but did modify body mass and lean mass. In females, intentional weight loss was associated with decreased exercise levels.DiscussionSEM is a useful tool for parsing complex systems in bone functional morphology and has the potential to uncover causal links in the study of skeletal remodeling, including factors like weight loss or exercise that may have secondary effects.
Efficient Self‐Sorting Behaviours of Metallacages with Subtle Structural Differences
Authors: Jin Tongxia , Zeng Kai , Zhang Xin , Dou Wei‐Tao , Hu Lianrui , Zhang Dawei , Zhu Weiping , Qian Xuhong , Yang Hai‐Bo , Xu Lin 
Published: July 2024

AbstractInvestigating the self‐sorting behaviour of assemblies with subtle structural differences is a captivating yet challenging endeavour. Herein, we elucidate the unusual self‐sorting behaviour of metallacages with subtle structural differences in batch reactors and microdroplets. Narcissistic self‐sorting of metallacages has been observed for two ligands with identical sizes, shapes, and symmetries, with only minor differences in the substituted groups. In particular, the self‐sorting process in microdroplets occurs within 1 min at room temperature, in stark contrast to batch reactors, which require equilibration for 30 min. To reveal the mechanism of self‐sorting and the role of microdroplets, we conducted a series of experiments and theoretical calculations, including competitive self‐assembly, cage‐to‐cage transformation, control experiments involving model metallacages with larger cavities, noncovalent interaction analysis, and root mean square deviation (RMSD) analysis. This research demonstrates an unusual case of self‐sorting of very similar assemblies and provides a new strategy for facilitating the self‐sorting efficiency of supramolecular systems.
High‐performance aminosilane‐infused alginate capsules for sustained drug release
Authors: Imanishi Sora , Sawano Yuji , Kurayama Fumio , Shibata Yuichi , Matsuyama Tatsushi , Ida Junichi 
Published: July 2024

AbstractSodium alginate (AlgNa) is often used to prepare oral drug capsules, offering the advantages of facile carrier formation and pH sensitivity. However, these capsules suffer from high porosity, large pore size, and mechanical and physiological instabilities. Although the performance of AlgNa in oral drug carriers can be enhanced through hybridization with other substances, this results in increased complexity and additional preparation steps. To address this problem, organic–inorganic hybrid capsules are herein prepared via the one‐step incorporation of aminosilanes (3‐aminopropyltriethoxysilane and 3‐(2‐aminoethylamino)propyltrimethoxysilane) into AlgNa and evaluated as delivery vehicles for the sustained release of a model drug, diclofenac sodium. The hybrid capsules show elevated drug encapsulation efficiencies (up to 92.7%) and pH responsiveness and outperform pure alginate capsules, exhibiting contraction and low release rates (<10%) in a simulated stomach environment (pH 1.2) and swelling and sustained release (10 h) in a simulated intestinal environment (pH 7.4). The formation of siloxane bonds between the aminosilane molecules results in stronger and more compact capsule membranes contributing to sustained drug release. Thus, our results demonstrate the potential of the proposed capsules, fabricated using a simple ecofriendly method, as carriers for sustained drug release.
Diphenylbutadiene Fluorescent Analogues in Sub‐Cellular Imaging and Monitoring Mitophagy
Authors: Ghorpade Mohini , Mansuri Abdulkhalik , Kumar Ashutosh , Kanvah Sriram 
Published: July 2024

AbstractA series of donor‐acceptor (D–π–A) substituted diphenylbutadienes exhibiting solvatochromic emission and a large Stokes shift (100–200 nm) were designed and synthesized for distinctive organelle labelling, enabling real‐time monitoring of organelle behaviour such as lysosomal dynamics, mitophagy monitoring, and stress responses. The morpholine‐substituted D–A–D diphenylbutadiene (M2) was employed to investigate selective imaging of lysosomes, the uptake of damaged mitochondria through mitophagy, and monitoring lysosomal viscosity or pH changes. Other diphenylbutadiene derivatives (M1, M3, M4) selectively accumulated in lipid droplets. All the synthesized derivatives demonstrated significant uptake in 5‐day post‐fertilization zebrafish larvae, with M2 showing maximum uptake in the enterocyte‐containing heart and intestinal regions, which include the lysosomes.
Ultrasound‐Assisted Advanced Oxidation Process Using Perovskite‐Type LaMnO3 Nanospheres
Authors: Maridevaru Madappa C , Kaimal Reshma , Selvaraj Rengaraj , Al Souwaileh Abdullah , Sun Ming Xuan , Anandan Sambandam , Ashokkumar Muthupandian 
Published: July 2024

AbstractAmong the perovskite oxide community, La‐based perovskites have garnered considerable interest due to their remarkable properties including catalytic, electrocatalytic, photocatalytic, sensing, electrical, magnetic, and optical characteristics. Herein, rhodamine‐B (RB) dye has been reported to be sono‐catalytically decomposed by an ultrasound‐assisted advanced oxidation process (AOP) using perovskite‐type LaMnO3 (LMO) nanospheres synthesized via ultrasonic approach. Several physiochemical characterizations such as XRD, FT‐IR, XPS, SEM, TEM, and SEM‐EDS investigations were used to investigate the LMO perovskite nanospheres. Then, LMO potential for adsorption and the sonocatalytic decolorization of RB dye in an aqueous solution are examined. With LMO perovskites, the adsorption and removal kinetics of RB correspond to the pseudo‐first‐order model. Furthermore, by utilizing the pseudo‐first‐order, the RB dye process is removed with improved efficacy in the following sequence: Agitation alone: 3.76×10−4 min−1<US only: 5.02×10−3 min−1<LMO only: 5.85×10−3 min−1<LO@MO + US: 1.38×10−2 min−1<LMO + US: 1.75×10−2 min−1, accordingly. Perovskite‐type LMO, which has significant reusability and stability, is an ensuring sonocatalyst for dye decomposition in wastewater, enabling faster decolorization. A prospective mechanism has been suggested for the sonocatalytic decomposition of RB.
Exploring potential ion channel targets for rheumatoid arthritis: combination of network analysis and gene expression analysis
Authors: Bhuvaneshwari Sampath , Venkataraman Krishnamurthy , Sankaranarayanan Kavitha 
Published: July 2024

AbstractRheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation of the synovial membrane that leads to the destruction of cartilage and bone. Currently, pharmacological targeting of ion channels is being increasingly recognized as an attractive and feasible strategy for the treatment of RA. The present work employs a network analysis approach to predict the most promising ion channel target for potential RA‐treating drugs. A protein–protein interaction map was generated for 343 genes associated with inflammation in RA and ion channel genes using Search Tool for the Retrieval of Interacting Genes and visualized using Cytoscape. Based on the betweenness centrality and traffic values as key topological parameters, 17 hub nodes were identified, including FOS (9800.85), tumor necrosis factor (3654.60), TGFB1 (3305.75), and VEGFA (3052.88). The backbone network constructed with these 17 hub genes was intensely analyzed to identify the most promising ion channel target using network analyzer. Calcium permeating ion channels, especially store‐operated calcium entry channels, and their associated regulatory proteins were found to highly interact with RA inflammatory hub genes. This significant ion channel target for RA identified by theoretical and statistical studies was further validated by a pilot case–control gene expression study. Experimental verification of the above findings in 75 RA cases and 25 controls showed increased ORAI1 expression. Thus, with a combination of network analysis approach and gene expression studies, we have explored potential targets for RA treatment.
Untangling the threads of school wellbeing: Underlying assumptions and axes of normativity
Authors: Primdahl Nis Langer , Simovska Venka 
Published: July 2024

AbstractAt present, the concept of wellbeing in schools appears more muddled than ever, encompassing an even wider range of meanings, connotations and dimensions than when it first gained currency two decades ago. Drawing upon a systematic literature review on wellbeing in schools, this article conceptualises the normative tensions underpinning the understandings of wellbeing in schools and related critical discussions. Guided by the claim that educational notions of wellbeing are not neutral but always laden with values and interwoven with expansive ideas about what education in general, and school wellbeing in particular, should be and do, we analyse a range of conceptualisations by illuminating the underlying normative assumptions. Our argument is that the concept of wellbeing is not only shaped by but also subject to opposing forces and inherent tensions. We outline three ‘axes’ to highlight these central points of tension characterising the conceptualisations of wellbeing in the literature, thereby shedding light on the normative underpinnings. The three axes portray a spectrum of perspectives, moving from individual skills, competencies and affective states, through approaches that underscore the relational nature of wellbeing and the importance of interpersonal relationships, to more comprehensive conceptualisations that construe wellbeing as interconnected with aspects of the whole‐school environment and broader societal dynamics. Our conceptual analyses suggest that parallel to the concept of subjectivity, wellbeing can be construed as either detached, value‐neutral and decontextualised, or as enacted in specific social realms and co‐created in the interplay between interpersonal interactions and socio‐material dynamics.
Descartes on Place and Motion: A Reading through Cartesian Commentaries**
Authors: Strazzoni Andrea 
Published: July 2024

AbstractThis paper offers a reconstruction of the interpretations of Descartes's ideas of place and motion by Dutch Cartesians (Henricus Regius, Johannes de Raey, Johannes Clauberg, and Christoph Wittich). It does so by focusing on the reading of Descartes's Principia philosophiae (1644) offered, in particular, by the dictated commentaries on it. It is shown how such commentaries bring to the light new potential Aristotelian‐Scholastic sources of Descartes, and the different ways Dutch Cartesians brought to the fore, also with the help of such sources, the rationale of the Cartesian text: in doing so, they constituted a philosophical school.
Enhanced chemiluminescence resonance energy transfer using surfactant‐modified AIE carbon dots
Authors: Zhong Jinpan , Zhu Yangwen , Xing Mengyan , Li Mengyan , Wu Riliga , Zhang Li , Guan Weijiang 
Published: July 2024

AbstractChemiluminescence resonance energy transfer (CRET) efficiency can be enhanced by confining CRET donors and acceptors within nanoscale spaces. However, this enhanced efficiency is often affected by uncertainties stemming from the random distribution of CRET donors and acceptors in such confined environments. In this study, a novel confined nanospace was created through the surfactant modification of carbon dots (CDs) exhibiting aggregation‐induced emission (AIE) characteristics. Hydrophobic CRET donors could be effectively confined within this nanospace. The distance between the CRET donors and acceptors could be controlled by anchoring the AIE‐CDs as the CRET acceptors, resulting in significantly improved CRET efficiency. Furthermore, this AIE‐CDs‐based CRET system was successfully applied to the detection of hydrogen peroxide (H2O2) in rainwater, showcasing its potential for practical applications.
Designed fluorescence “on–off–on” probe based on cobalt, zinc, and nitrogen co‐doped graphene quantum dots: A case of quinalphos sensing
Authors: Mahajan Mahendra R. , Patil Pravin O. 
Published: July 2024

AbstractIn this study, we developed a new fluorescence “on–off–on” sensor utilizing water‐soluble cobalt/zinc–nitrogen co‐doped graphene quantum dots (Co/Zn‐N‐GQDs) to recognize quinalphos pesticide in vegetable and fruit samples. Primarily, the synthesis method employed a one‐pot hydrothermal approach, using betel leaves as a natural precursor and cobalt (“Co”), zinc (“Zn”), and urea (“N”) as dopant sources. The Co/Zn‐N‐GQDs probes underwent comprehensive analytical characterization. The Co/Zn‐N‐GQDs were synthesized with a remarkable luminescence yield of 31.49%, exhibiting excitation at 320 nm and emission peak at 393 nm. Interestingly, the luminescence of Co/Zn‐N‐GQDs was selectively “Turned Off” by Cu2+ via a static quenching setup. Remarkably, quenched fluorescence was surprisingly reactivated upon adding quinalphos to the quench setup, indicating a direct correlation between luminescence reactivation and quinalphos concentration. Briefly, this phenomenon is ascribed to the functional groups in quinalphos, such as quinoxalinyl and phosphorothioate, which chelate with Cu2+ ions, disrupting the nonfluorescent Cu2+‐Co/Zn‐N‐GQDs complex. The design sensor demonstrated a limit of detection (LOD) of 0.11 μM and a broad linear span of 0.5 to 200 μM. In conclusion, Cu2+‐Co/Zn‐N‐GQDs sensor showed immediate applicability, stability, and reproducibility, making it highly effective for quinalphos sensing in various samples.