bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Highly Regioselective Synthesis of Aryl Chalcogenides Through C—H Functionalization of Arenes.
Authors: Cheng Jun‐Hao , Yi Chih‐Lun , Liu Tsung‐Jui , Lee Chin‐Fa 
Published: November 2012

AbstractThe regioselective synthesis of title compounds (III) and (V) through the Ir‐catalyzed meta C—H borylation followed by Cu‐catalyzed C—S coupling reaction with chalcogenide sources (II) and (IV) in one‐pot, giving the 3,5‐disubstituted aryl chalcogenides with high regioselectivity is reported.
ChemInform Abstract: Unexpected Formation of 4‐Arylcyclopentane‐1,1,3,3‐tetracarboxylates (II) in GaCl3‐Catalyzed Reaction of 2‐Arylcyclopropane‐1,1‐dicarboxylates (I) with Tetrasubstituted 1‐Pyrazolines.
Authors: Novikov Roman A. , Tomilov Yury V. , Nefedov Oleg M. 
Published: November 2012

AbstractThe Lewis acid‐catalyzed reaction of 2‐arylcyclopropane‐1,1‐dicarboxylates (I) in the presence of pyrazoline dicarboxylates (III) containing no hydrogen atoms in C‐3 or C‐5 positions of the heterocycle is presented.
ChemInform Abstract: Pd(0) NPs: A Novel and Reusable Catalyst for the Synthesis of Bis(heterocyclyl)methanes in Water.
Authors: Saha Mithu , Pal Amarta Kumar , Nandi Shibaji 
Published: November 2012

AbstractHydroxy coumarin (I), indole (IV), dimedone (VI), and pyrazole (VIII) react with various aromatic aldehydes (II) in the presence of in situ generated palladium nanoparticles giving the title compounds in high yields.
ChemInform Abstract: Stereoselective Double Lewis Acid/Organo‐Catalyzed Dimerization of Donor—Acceptor Cyclopropanes into Substituted 2‐Oxabicyclo[3.3.0]octanes.
Authors: Novikov Roman A. , Timofeev Vladimir P. , Tomilov Yury V. 
Published: November 2012

AbstractIn the presence of GaCl3 and the pyrazoline, cyclopropanes of type (I) undergo new and stereoselective dimerization to afford oxabicyclooctanes like (II).
ChemInform Abstract: Synthetic Approach Toward cis‐Disubstituted γ‐ and δ‐Lactones Through Enantioselective Dialkylzinc Addition to Aldehydes: Application to the Synthesis of Optically Active Flavors and Fragrances.
Authors: Pisani Laura , Superchi Stefano , D'Elia Alessandra , Scafato Patrizia , Rosini Carlo 
Published: November 2012

AbstractThe synthesis of the cis‐whisky lactone (VIIc) based on enantioselective catalysis is presented for the first time.
ChemInform Abstract: 1,3‐Dipolar Cycloaddition Reaction of 3‐Trifluoromethyl‐4‐diazopyrazolinones with Acetylenedicarboxylates.
Authors: Zhang Zhenhua , Wang Xiaowei , Tao Song , Zhu Shizheng 
Published: November 2012

AbstractTwo different methods for the preparation of the title compounds from the compounds (II) are successfully developed.
ChemInform Abstract: Synthesis of 1,2,4,5‐Tetrasubstituted Imidazoles Using Sulfuric Acid ([3‐(3‐Silicapropyl)sulfanyl]propyl)ester as a Recyclable Solid Acid.
Authors: Tavakoli Ziba , Bagherneghad Mojtaba , Niknam Khodabakhsh 
Published: November 2012

AbstractThe title acid catalyzes the four‐component condensation of benzil (I), aliphatic and aromatic amines (II), aromatic aldehydes (III), and ammonium acetate under solvent‐free conditions, possibly by increasing the electrophilicity of the carbonyl group of (I) and (III).
ChemInform Abstract: Synthesis of a New Class of Arylsulfonylethylsulfonylmethyloxazolines and Thiazolines.
Authors: Padmavathi Venkatapuram , Venkatesh Bhumireddy C. , Premakumari Chokkappagari , Padmaja Adivireddy 
Published: November 2012

AbstractThe entitled compounds (III) are formed using a multistep one‐pot methodology exploiting either lanthanide catalysis or microwave irradiation in a single step with high yields.
ChemInform Abstract: Facile One‐Pot Procedure for the Synthesis of 2‐Aminothiazole Derivatives.
Authors: Yin Guodong , Ma Junrui , Shi Houqiang , Tao Qing 
Published: November 2012

Abstractα‐Bromination of aromatic methyl ketones (I) followed by cyclization with thiourea derivatives (II) affords aminothiazole derivatives (III) in moderate to good yields.
ChemInform Abstract: Multi‐Component Synthesis of 2‐Amino‐6‐(alkylthio)pyridine‐3,5‐dicarbonitriles Using Zn(II) and Cd(II) Metal—Organic Frameworks (MOFs) under Solvent‐Free Conditions.
Authors: Thimmaiah Muralidhara , Li Peng , Regati Sridhar , Chen Banglin , Zhao John Cong‐Gui 
Published: November 2012

AbstractBoth MOF′s (I) reveal analogous efficiency concerning reaction time and yield.
ChemInform Abstract: Ring Expansion of Cyclic β‐Amino Alcohols Induced by Diethylaminosulfur Trifluoride: Synthesis of Cyclic Amines with a Tertiary Fluorine at C‐3.
Authors: Anxionnat Bruno , Robert Benoit , George Pascal , Ricci Gino , Perrin Marc‐Antoine , Gomez Pardo Domingo , Cossy Janine 
Published: November 2012

AbstractThe ring expansion of 2‐hydroxymethyl azetidines and prolinols proceeds with high enantioselectivity for small rings.
ChemInform Abstract: A New and Facile Access to the 2‐(Indol‐3‐yl)‐3‐nitriloquinolines Based on Friedlaender Annulations.
Authors: Shiri Morteza , Zolfigol Mohammad Ali , Pirveysian Mahtab , Ayazi‐Nasrabadi Roya , Kruger Hendrik G. , Naicker Tricia , Mohammadpoor‐Baltork Iraj 
Published: November 2012

AbstractA multi‐step one‐pot procedure for the synthesis of the title compounds is reported in relative short reaction times.
ChemInform Abstract: An Efficient Method for the Synthesis of 4‐Arylfuro[2,3‐a][4,7]phenanthroline Derivatives Catalyzed by Iodine.
Authors: Wang Xiang‐Shan , Yin Ming‐Yue , Wang Shu‐Liang , Wang Wei , Li Yu‐Ling 
Published: November 2012

AbstractThe title compounds (IV) are efficiently obtained in a three‐component one‐pot reaction of various aromatic aldehydes (13 examples) with quinilin‐6‐amine (I) and 2,3‐dihydrofuran (III) under mild reaction conditions.
ChemInform Abstract: Benzo[b]furan in the Povarov Reaction.
Authors: Krainova Gulnaz F. , Chudinova Yulia O. , Gorbunov Alexey A. , Mayorova Olga A. , Glushkov Vladimir A. 
Published: November 2012

AbstractPovarov‐type condensation of benzofuran with Schiff bases provides access to benzofuroquinoline derivatives.
ChemInform Abstract: Bis(α‐bromo ketones): Versatile Precursors for Novel Bis(s‐triazolo[3,4‐b][1,3,4]thiadiazines) and Bis(as‐triazino[3,4‐b][1,3,4]thiadiazines).
Authors: Shaaban Mohamed R. , Elwahy Ahmed H. M. 
Published: November 2012

AbstractCyclization of bis(α‐bromoketones) (II) and (VII) with aminotriazoles (III) and aminotriazine (VIII), resp., provides access towards title fused thiadiazines (IV) and (IX), resp., in moderate yields.
ChemInform Abstract: Copper(I)‐Catalyzed Cascade Sulfonimidate to Sulfonamide Rearrangement: Synthesis of Imidazo[1,2‐a][1,4]diazepin‐7(6H)‐one.
Authors: Nagaraj Muthupandi , Boominathan Muthusamy , Perumal Devanathan , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: November 2012

AbstractCu‐mediated treatment of alkynols of type (I) with sulfonyl azides results in formation of ketenimines which spontaneously undergo cyclization to sulfonimidates and rearrangement to sulfonamides.
ChemInform Abstract: Copper(I)‐Catalyzed Regio‐ and Chemoselective Single and Double Addition of Nucleophilic Silicon to Propargylic Chlorides and Phosphates.
Authors: Hazra Chinmoy K. , Oestreich Martin 
Published: November 2012

AbstractTreatment of linear propargylic chlorides and phosphates with equimolar amounts of Zn agents (II) and (IX) allows an efficient and regioselective formation of silylated allenes.
ChemInform Abstract: Asymmetric Synthesis of (—)‐(R)‐Massoia Lactone (V), (R)‐δ‐Decalactone (VI), and (+)‐(3R,5R)‐3‐Hydroxydecano‐5‐lactone (IX). Formal Synthesis of Verbalactone (X).
Authors: Mineeva I. V. 
Published: November 2012

Abstractinvolving asymmetric allylation of hexanal with stannane (II) as the key step
ChemInform Abstract: Nonstoichiometry in Inorganic Fluorides: Part 1. Nonstoichiometry in MFm—RFn (m < n ≤ 4) Systems
Authors: Sobolev B. P. 
Published: November 2012

AbstractReview: synthesis, phase diagrams, and crystal growth in title systems with M: alkali etals, alkaline earth metals, transition metals and R: lanthanoids; 66 refs.
ChemInform Abstract: Synthesis of Extended Porphyrins by Connection of meso‐Aryl Groups with β‐Pyrrolic Positions
Authors: Pereira Ana M. V. M. , Richeter Sebastien , Jeandon Christophe , Gisselbrecht Jean‐Paul , Wytko Jennifer , Ruppert Romain 
Published: November 2012

AbstractReview: 91 refs.
Synthesis of Transition‐Metal Exchanged Nanocrystalline ZSM‐5 and Their Application in Electrochemical Oxidation of Glucose and Methanol
Authors: Kaur Balwinder , Anu Prathap M. U. , Srivastava Rajendra 
Published: November 2012

AbstractNanocrystalline ZSM‐5 was prepared using propyltriethoxysilane. Materials were characterized by a complementary combination of X‐ray diffraction, nitrogen sorption, and scanning electron microscopy. Transition‐metal ion exchanged nanocrystalline ZSM‐5‐modified electrodes were constructed for the electrocatalytic oxidation of glucose and methanol. A non‐enzymatic electrochemical sensor based on a Ni2+‐exchanged nanocrystalline ZSM‐5‐modified electrode exhibits the highest sensing ability, whereas the corresponding Cu2+‐exchanged electrode exhibits the highest current sensitivity for glucose oxidation. Among the variety of electrodes modified with transition‐metal ion exchanged nanocrystalline ZSM‐5, the Ni2+‐exchanged electrode exhibits high current sensitivity and sensing ability in methanol oxidation. Electrocatalytic activity of conventional ZSM‐5‐modified electrodes was significantly low compared to nanocrystalline ZSM‐5‐modified electrodes. Enhancement in the electrocatalytic activities of nanocrystalline ZSM‐5‐modified electrodes can be correlated with the enhanced accessibility of glucose/methanol to M2+ active centers in the nanocrystalline ZSM‐5 owing to its large specific surface area and intercrystalline mesopores. The sensor was applied directly to determine glucose concentration in adult human blood serum, and the precision of the method was found to be satisfactory. The non‐enzymatic sensor exhibited excellent reproducibility, repeatability, stability, and antifouling ability for direct determination of glucose in human blood serum.
Serial anthropometry predicts peripheral nerve dysfunction in a community cohort
Authors: Ylitalo Kelly R. , Herman William H. , Harlow Siobán D. 
Published: November 2012

AbstractBackgroundObesity is a risk factor for glucose intolerance, but the independent role of obesity in the development of peripheral neuropathy is unclear. This study assessed the impact of body size trajectories on prevalent nerve dysfunction in community‐dwelling women with and without glucose intolerance.MethodsAnnual (1996–2008) anthropometric measures of weight, height, waist circumference and body mass index [BMI, weight (kg)/height (m2)] were assessed in the Study of Women's Health Across the Nation – Michigan site. Glucose intolerance was defined annually on the basis of current use of diabetes medications, self‐reported diabetes diagnosis and, when available, fasting glucose. Peripheral nerve dysfunction in 2008 was defined as abnormal monofilament testing or ≥4 symptoms or signs. Linear mixed models were used to determine trajectories of anthropometry by subsequently identified nerve dysfunction status.ResultsMean BMI was 32.4 kg/m2 at baseline, and 27.8% of the women had nerve dysfunction in 2008. BMI, weight and waist circumference increased over time. Women who would have nerve dysfunction were significantly larger than women without dysfunction, independent of glucose intolerance. At mean baseline age of 46, BMI, weight and waist circumference differed significantly (p‐value < 0.01) by subsequent nerve dysfunction status, independent of glucose intolerance and hypertension. These body size differences were maintained but not exacerbated over time.ConclusionsPeripheral nerve dysfunction is prevalent among community‐dwelling women. Twelve years before the nerve assessment, anthropometry differed between women who would and would not have nerve dysfunction, differences that were maintained over time. Obesity deserves attention as an important and potentially modifiable risk factor for peripheral nerve dysfunction. Copyright © 2012 John Wiley & Sons, Ltd.
The influence of the type of oil phase on the self‐assembly process of γ‐oryzanol + β‐sitosterol tubules in organogel systems
Authors: Sawalha Hassan , Margry Giel , den Adel Ruud , Venema Paul , Bot Arjen , Flöter Eckhard , van der Linden Erik 
Published: November 2012

AbstractMixtures of γ‐oryzanol and β‐sitosterol were used to structure different oils (decane, limonene, sunflower oil, castor oil, and eugenol). The γ‐oryzanol and β‐sitosterol mixtures self‐assemble into double‐walled hollow tubules (∼10 nm in diameter) in the oil phase, which aggregate to form a network resulting in firm organogels. The self‐assembly of the sterol molecules into tubules was studied using light scattering and rheology. By using different oils, the influence of the polarity of the oil on the self‐assembly was studied. The effects of temperature and structurant concentration on the tubuler formation process were determined and the thermodynamic theory of self‐assembly was applied to calculate the change in Gibbs free energy (ΔG0), enthalpy (ΔH0), and entropy (ΔS0) resulting from the aggregation of the structurants was determined. The self‐assembly was found to be enthalpy‐driven as characterized by a negative ΔH0 and ΔS0. A decreasing polarity of the oil promotes the self‐assembly leading to formation of tubules at higher temperatures and lower structurant concentrations.
Detection of adulteration of sesame and peanut oils via volatiles by GC × GC–TOF/MS coupled with principal components analysis and cluster analysis
Authors: Zhao Fangfang , Liu Jingkun , Wang Xiupin , Li Peiwu , Zhang Wen , Zhang Qi 
Published: November 2012

AbstractThe method of headspace coupled with comprehensive two‐dimensional GC–time‐of‐flight MS (HS‐GC × GC–TOF/MS) was applied to differentiate the volatile flavor compounds of three types of pure vegetable oils (sesame oils, peanut oils, and soybean oils) and two types of adulterated oils (sesame oils and peanut oils adulterated with soybean oils). Thirty common volatiles, 14 particular flavors and two particular flavors were identified from the three types of pure oils, from the sesame oils, and from the soybean oils, respectively. Thirty‐one potential markers (variables), which are crucial to the forming of different vegetable oil flavors, were selected from volatiles in different pure and adulterated oils, and they were analyzed using the principal component analysis (PCA) and cluster analysis (CA) approaches. The samples of three types of pure vegetable oil were completely classified using the PCA and CA. In addition, minimum adulteration levels of 5 and 10% can be differentiated in the adulteration of peanut oils and sesame oils with soybean oils, respectively.Practical applications: The objective was to develop one kind of potential differentiated method to distinguish high cost vegetable oils from lower grade and cheaper oils of poorer quality such as soybean oils. The test result in this article is satisfactory in discriminating adulterated oils from pure vegetable oils, and the test method is proved to be effective in analyzing different compounds. Furthermore, the method can also be used to detect other adulterants such as hazelnut oil and rapeseed oil. The method is an important technical support for public health against profit‐driven illegal activities.
Manganese(III) acetate induced radical addition of azide to unsaturated fatty compounds
Authors: Biermann Ursula , Linker Ursula , Metzger Jürgen O. 
Published: November 2012

AbstractNitrogen functionalities can be introduced in the alkyl chain of unsaturated fatty compounds by addition of azide mediated by manganese(III) acetate. The respective reaction of methyl oleate 1 containing an internal C,C double bond gave allyl azide 3 as a mixture of 4 regioisomers while the addition of azide to the terminal C,C double bond of methyl 10‐undecenoate 2 afforded the vicinal diazide 6. Azide 3 could be easily converted to the saturated amine 4 by catalytic hydrogenation and to the allyl amines 5 by the Staudinger reaction.
An Efficient Catalytic Method for Regioselective Sulfenylation of Electron‐Rich Aza‐Aromatics at Room Temperature
Authors: Marcantoni Enrico , Cipolletti Roberto , Marsili Laura , Menichetti Stefano , Properzi Roberta , Viglianisi Caterina 
Published: November 2012

AbstractElectron‐rich aza‐aromatic compounds such as indoles and pyrroles are structures of particular interest and importance in organic chemistry. A useful methodology for the regioselective introduction of the sulfenyl group into electron‐rich aza‐aromatics using S‐alkyl‐ and S‐arylthiophthalimides as sulfenylating agents is described. Catalytic amounts of CeCl3·7H2O/NaI are crucial to the promotion of this regioselective carbon–sulfur‐bond‐forming electrophilic aromatic substitution reaction. The reaction occurred under mild conditions, and the products were obtained in good to excellent yields. The method represents an efficient preparation of sulfenyl aza‐aromatics, which are useful intermediates for important organic transformations, due to the great importance of functionalized indoles among natural compounds and pharmaceutical products.
A Sensitive Simultaneous Determination of Epinephrine and Piroxicam Using a Glassy Carbon Electrode Modified with a Nickel Hydroxide Nanoparticles/Multiwalled Carbon Nanotubes Composite
Authors: Babaei Ali , Sohrabi Masoud , Afrasiabi Mohammad 
Published: November 2012

AbstractThe electrooxidation of epinephrine (EPI) and piroxicam (PRX) has been investigated by application of nickel hydroxide nanoparticles/multiwalled carbon nanotubes composite electrode (MWCNTs‐NHNPs/GCE) using cyclic voltammetry (CV), differential pulse voltammetry (DPV) and chronoamperometry (CA) methods. The modified electrode showed suitable electrochemical responses for EPI and PRX determination. Under the optimum conditions the electrode provides a linear response versus EPI and PRX concentrations in the range of 1–220 µM and 0.7–75 µM, respectively using the DPV method. Linear responses versus EPI and PRX concentrations in the range of 1–1000 µM and 1–800 µM, respectively, were obtained using the CA method. The modified electrode was used for determination of EPI and PRX in human urine with satisfactory results.
Strategy for the creation of clinical grade hESC line banks that HLA‐match a target population
Authors: Jacquet Laureen , Stephenson Emma , Collins Robert , Patel Heema , Trussler Jane , Al‐Bedaery Roaa , Renwick Pamela , Ogilvie Caroline , Vaughan Robert , Ilic Dusko 
Published: November 2012

AbstractHere, we describe a pre‐derivation embryo haplotyping strategy that we developed in order to maximize the efficiency and minimize the costs of establishing banks of clinical grade hESC lines in which human leukocyte antigen (HLA) haplotypes match a significant proportion of the population. Using whole genome amplification followed by medium resolution HLA typing using PCR amplification with sequence‐specific primers (PCR‐SSP), we have typed the parents, embryos and hESC lines from three families as well as our eight clinical grade hESC lines and shown that this technical approach is rapid, reliable and accurate. By employing this pre‐derivation strategy where, based on HLA match, embryos are selected for a GMP route on day 3–4 of development, we would have drastically reduced our cGMP laboratory running costs.
Promises and problems for the new paradigm for risk assessment and an alternative approach involving predictive systems models
Authors: Forbes Valery E. , Calow Peter 
Published: November 2012

Abstract
The need for cost-effective risk assessment of chemicals is leading to the development of a reductionist paradigm that tries to assess impacts on humans and ecosystems from molecular changes. However, the biggest challenge for this paradigm comes from the emergence of properties that arise out of the interactions of the parts that are not included and yet which are key for assessing likely impacts. Although identifying key events and adverse outcome pathways can shed light on the involvement of important metabolic processes in toxicity, this does not mean that particular molecular initiating events are likely to be robust or accurate predictors of impacts that matter. There are even greater challenges for the new paradigm applied to ecological systems than to human health because of the need to link across more levels of biological organization. The present study argues for a predictive systems approach that makes the linkages through systems models in a mechanistic way that allows for emergence and that also has the potential for reducing the costs and use of animals in ecological risk assessments. Environ. Toxicol. Chem. 2012; 31: 2663–2671. © 2012 SETAC
Synthesis and Photoluminescent Properties of New Aza‐Indenofluorene Derivatives
Authors: Jung Su Jin , Kim Won Sam , Park Byung Sun , Lee Jae Kyun , Park Jung Hwan , Choi Kihang , Lee So Ha 
Published: November 2012

ABSTRACTThe carbazole derivatives 5a–h were synthesized by four steps involving Suzuki coupling of boronic acid 1 with 1‐bromo‐2‐nitrobenzene, followed with the Cadogan ring closure reaction. Their UV and photoluminescence properties are also reported, and the compounds showed medium‐to‐strong photoluminescence between 370 and 446 nm at the concentration of 1 × 10−5 M CH2Cl2. Also, the X‐ray structure of the carbazole derivative 6 was elucidated by an X‐ray diffractometer. © 2012 Wiley Periodicals, Inc. Heteroatom Chem 24:18–24, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/hc.21058
An Ageing‐in‐Place Service Innovation Model by Using TRIZ Methodology
Authors: Chen Chi‐Kuang , Shie An‐Jin , Wang Kuo‐Ming , Yu Chang‐Hsi 
Published: November 2012

AbstractMost of the research on the concept of “ageing‐in‐place” has focused on surveys of the needs of senior citizens and/or the quality of the services delivered to them. Service innovation for ageing‐in‐place has received little research attention, however. The present study addresses this issue by proposing a service innovation model for ageing‐in‐place. In this model, a TRIZ methodology is used to develop the parameter correspondence table, which integrates TRIZ contradiction parameters and ageing‐in‐place service‐quality determinants, to deal with service contradiction. A TRIZ contradiction matrix is then applied to generate inventive solutions for the innovation of the ageing‐in‐place service system. A case study is also conducted to demonstrate the applicability of the proposed model.
Toward the Synthesis of Modified Carbohydrates by Conjugate Addition of Propane‐1,3‐dithiol to α,β‐Unsaturated Ketones
Authors: Valdersnes Stig , Apeland Ingrid , Flemmen Guri , Sydnes Leiv K. 
Published: November 2012

AbstractSelected 5‐substituted derivatives 4 of 1,1‐diethoxy‐5‐hydroxypent‐3‐yn‐2‐one were treated with propane‐1,3‐dithiol under various conditions. The unprotected hydroxy ketones underwent cyclization during the dithiol addition and gave the corresponding 3‐(diethoxymethyl)‐2‐oxa‐6,10‐dithiaspiro[4.5]decan‐3‐ols 5 in 80–90% yield as the only products (Scheme 3 and Table 1). These products can be regarded as partly modified carbohydrates in the furanose form. When the benzyl‐protected analogues 10‐Bn of the 1,1‐diethoxy‐5‐hydroxypent‐3‐yn‐2‐one derivatives were treated with the same dithiol, however, no cyclization occurred; instead the corresponding 3‐{2‐[(benzyloxy)methyl]‐1,3‐dithian‐2‐yl}‐1,1‐diethoxypropan‐2‐one derivatives 11‐Bn were formed in good yield (up to 99%; Table 4). These 1,3‐dithianes were and are in the process of being converted to a number of new carbohydrate analogues, and here are reported high‐yield syntheses of functionalized molecules 17 belonging to the 5,5‐diethoxy‐1,4‐dihydroxypentan‐2‐one family of compounds (Table 7), via 15‐Bn (Table 5) and 16‐Bn (Table 6 and Scheme 8).