bluuebunny/crossref_metadata_2025_split huggingface dataset:
A cross-sectional study of medial longitudinal arch development in children with different BMI
Authors: Chen Jing , Tang Li , Yang Xiaoxuan , Tang Jing , Cheng Qingfeng , Zhao Chen , Zhang Han 
Published: July 2024

IntroductionThe influence of excess weight on the development of children's feet remains a subject of debate. To further elucidate whether this relation occurs, this study compared arch morphology and flexibility in three groups of children: underweight, normal, and overweight.MethodsIn total, 1,532 children (807 boys, 725 girls; age range 7–11 years) participated in the study. The researchers measured the participants’ height and weight, calculated their body mass index, and categorized their weight status as underweight, normal weight, or overweight. A three-dimensional foot model was taken using a three-dimensional plantar scanner under non-weight-bearing and weight-bearing conditions to obtain arch morphometric indices (arch index and arch volume) and arch flexibility index (arch volume index).ResultsAnalysis of the data showed that the arch index was higher in overweight children compared to underweight and normal weight children (p &lt; 0.05), but the differences in arch volume and arch volume index in overweight children compared to underweight and normal weight children were not statistically significant (p &gt; 0.05). All children were divided into flatfoot, normal, and pes cavus groups according to arch index, and the arch volume index was statistically significant (p &lt; 0.01).ConclusionsOverweight was not absolutely associated with arch structure and arch flexibility in children from a three-dimensional perspective. Arch development is a long-term process, and it is not clear whether being overweight has an effect on soft tissue or bone formation. Future studies will focus on the effects of long-term overweight on foot structure and arch flexibility in children.
Associations between body weight trajectories and neurodevelopment outcomes at 24 months corrected age in very-low-birth-weight preterm infants: a group-based trajectory modelling study
Authors: Wang Ts-Ting , Chen Yen-Ju , Su Yi-Han , Yang Yun-Hsiang , Chu Wei-Ying , Lin Wei-Ting , Chang Yu-Shan , Lin Yung-Chieh , Lin Chyi-Her , Lin Yuh-Jyh ,   Taiwan Premature Infant Follow-up Network
Published: July 2024

IntroductionThis study aimed to explore the relationship between the trajectories of body weight (BW) z-scores at birth, discharge, and 6 months corrected age (CA) and neurodevelopmental outcomes at 24 months CA.MethodsConducted as a population-based retrospective cohort study across 21 hospitals in Taiwan, we recruited 3,334 very-low-birth-weight (VLBW) infants born between 2012 and 2017 at 23–32 weeks of gestation. Neurodevelopmental outcomes were assessed at 24 months CA. Instances of neurodevelopmental impairment (NDI) were defined by the presence of at least one of the following criteria: cerebral palsy, severe hearing loss, profound vision impairment, or cognitive impairment. Group-based trajectory modeling was employed to identify distinct BW z-score trajectory groups. Multivariable logistic regression was used to assess the associations between these trajectories, postnatal comorbidity, and neurodevelopmental impairments.ResultsThe analysis identified three distinct trajectory groups: high-climbing, mid-declining, and low-declining. Significant associations were found between neurodevelopmental impairments and both cystic periventricular leukomalacia (cPVL) [with an adjusted odds ratio (aOR) of 3.59; p &lt; 0.001] and belonging to the low-declining group (aOR: 2.59; p &lt; 0.001).DiscussionThe study demonstrated that a low-declining pattern in body weight trajectory from birth to 6 months CA, along with cPVL, was associated with neurodevelopmental impairments at 24 months CA. These findings highlight the importance of early weight trajectory and specific health conditions in predicting later neurodevelopmental outcomes in VLBW infants.
First-line immune checkpoint inhibitors in low programmed death-ligand 1-expressing population
Authors: Zhang Feiyang , Chen Guoming , Yin Yixin , Chen Xiaojiang , Nie Runcong , Chen Yingbo 
Published: July 2024

Introduction: Inhibitors of programmed cell death 1 (PD1) and its ligand (PDL1) have exhibited favorable long-term survival in many types of advanced-stage cancer and current approvals have to date been granted in certain tumour types irrespective of PD-L1 status.Methods: We extracted the following information: study sample size, trial period, cancer types, intervention of treatment, type of PD-L1 antibody, immunohistochemistry (IHC) scoring method, number and percentage of PD-L1 &lt; 1% population, and median follow- up time. PD-L1 expression was defined as percentage of number of PD-L1-stained tumor cells (TPS), area of tumor infiltrated by PD-L1-stained immune cells (IPS), number of PD-L1-stained cells (tumor cells, lymphocytes and macrophages; CPS). Different trials used distinct method to define low PD-L1 expression. The risk of bias of the included trials was assessed by using the Cochrane risk of bias tool for RCTs.Results: Here, a total of 34 trials were included to extract individual patient data (IPD) to evaluate the survival benefit of first line PD1/PDL1 inhibitors vs. standard-of-care (SOC) in patients with PDL1 &lt; 1%. In term of anti-PD-1/PD-L1 monotherapy, OS (HR = 0.90, 0.81−1.01) and PFS (HR = 1.11, 0.97−1.27) between PD-1/PD-L1 inhibitor group and SOC group were comparable. In term of anti-PD-1/PD-L1 combination therapy, PD-1/PD-L1 inhibitor group exhibited longer OS (median 19.5 months vs. 16.3 months; HR = 0.83, 0.79−0.88, p &lt; 0.001) and PFS than those of SOC group (median 8.11 months vs. 6.96 months; HR = 0.82, 0.77−0.87, p &lt; 0.001).Subgroup analysis showed that survival benefit was mainly observed in non-small cell lung cancer (NSCLC) (HROS = 0.74; HRPFS = 0.69; p &lt; 0.001), small-cell lung cancer (SCLC) (HROS = 0.58, p &lt; 0.001; HRPFS = 0.55, p = 0.030), esophageal squamous cell carcinoma (ESCC) (HROS = 0.62, p = 0.005; HRPFS = 0.79, p &lt; 0.001), melanoma (HROS = 0.53, p &lt; 0.001) and nasopharyngeal carcinoma (NPC) (HRPFS = 0.35, p = 0.013).Conclusion: Anti-PD-1/PD-L1 combinational therapy rather than monotherapy exhibit survival benefit in the low PD-L1 population in the first-line setting, and the survival benefit was mainly observed in specific tumor types.
Gestodene, a novel positive allosteric modulator of PAR1, enhances PAR1-mediated human platelet aggregation
Authors: Park So-Hyeon , Heo Yunkyung , Kwon Il , Jo Sungwoo , Jeon Hyejin , Lee Yechan , Kim Jieun , Heo Ji Hoe , Namkung Wan 
Published: July 2024

Background: Protease-activated receptor 1 (PAR1) is expressed in human platelets and can be activated by low concentrations of thrombin. Vorapaxar, a selective antagonist of PAR1, inhibits thrombin-induced calcium mobilization in human platelet, which is associated with an increased risk of bleeding. Conversely, the administration of a positive allosteric modulator (PAM) of PAR1 may pose a substantial risk of thrombosis due to inducing excessive platelet activation. In this study, we discovered a novel PAM of PAR1 and investigated the effect of enhanced PAR1 activation by PAM of PAR1 on platelet activation.Methods: To find PAMs of PAR1, a cell-based screen was performed in HT29 cells, and finally, gestodene, an oral contraceptive drug (OC), was identified as a novel PAM of PAR1. The mechanism of action of gestodene and its effects on platelet activation were investigated in human megakaryocytic leukemia cell line MEG-01 cells and human platelet.Results: Gestodene enhanced both thrombin- and PAR1-activating peptide (AP)-induced intracellular calcium levels in a dose-dependent manner without altering PAR2 and PAR4 activity. Gestodene significantly increased PAR1-AP-induced internalization of PAR1 and phosphorylation of ERK1/2, and the enhancing effects were significantly blocked by vorapaxar. Furthermore, gestodene potently increased PAR1-AP induced morphological changes in MEG-01 cells. Remarkably, in human blood, gestodene exerted a robust augmentation of PAR1-AP-induced platelet aggregation, and vorapaxar effectively attenuated the gestodene-induced enhancement of platelet aggregation mediated by PAR1.Conclusion: Gestodene is a selective PAM of PAR1 and suggest one possible mechanism for the increased risk of venous thromboembolism associated with OCs containing gestodene.
Factors associated with contemporary fatherhood
Authors: Hershkovitz-Freudenthal Adi , Lavenda Osnat 
Published: July 2024

IntroductionThe most prevalent conceptualization of parenting of our time is intensive parenting which refers to parents’ overinvolvement in children’s lives, placing the child’s needs before others’ needs, including the needs of the parents themselves (i.e., Child-centrism). Intensive parenting is mostly attributed to mothers as they are still bearing the bulk responsibility for child rearing. Nevertheless, as the role of fathers changed in recent decades it is crucial to examine intensive parenting among fathers and understand whether factors that are associated with intensive mothering are associated with intensive fatherhood as well. The current study uses Belsky’s Process of Parenting model to fill-in the gap.MethodsParticipants were 301 Israeli fathers of preschool children aged 22 to 50 years old (M=36.34, SD=5.01). They filled out online self-report questionnaires dealing with intensive parenting style, child temperament, social support, marital satisfaction, and parental self-efficacy.ResultsThe model explained 64% of paternal child-centrism. Fathers who reported having children with more difficult temperament, reported low social support, low marital satisfaction, and low self-efficacy, were more intensive in their parenting style.DiscussionThe present findings are discussed in relation to previous findings regarding maternal child-centrism with an emphasis on their important implications for professionals working with families for the benefit of parents’ and children’s wellbeing.
Obstructive sleep apnea and 19 gastrointestinal diseases: a Mendelian randomization study
Authors: Yan Weiheng , Zhou Jiayi , Jiang Miaomiao , Kong Yaru , Qin Han , Qi Yuwei , Wang Shan , Tai Jun 
Published: July 2024

BackgroundAlterations gastrointestinal diseases (GDs) were reported in individuals with obstructive sleep apnea (OSA), however, the genetic background between OSA and GDs is still unclear.MethodsThis investigation employed Mendelian randomization (MR) analyses to evaluate the causal effect between OSA and 19 types of GDs (gastroesophageal reflux disease (GERD), ulcerative colitis, celiac disease, Crohn’s disease, chronic gastritis, irritable bowel syndrome, primary biliary cholangitis, diverticular disease, gastroduodenal ulcer, acute pancreatitis, non-alcoholic fatty liver disease, primary sclerosing cholangitis, cirrhosis, calculus of bile duct, calculus of gallbladder, pancreatic cancer, gastric cancer, colorectal cancer, and esophageal cancer). The inverse-variance weighted (IVW) method was used to evaluate the main effects model of causality.ResultsThis MR study suggests that OSA may play a causal role inflammation-related GDs (GERD, PIVW=5.94×10-9; gastroduodenal ulcer, PIVW=1×10-4; chronic gastritis, PIVW=0.0214; ulcerative colitis, PIVW=0.0296), and gallstones (calculi of the gallbladder, PIVW=0.0429; calculi of the bile duct, PIVW=0.0068). After accounting for obesity, type 2 diabetes, smoking, and alcohol consumption, the multivariate MR (MVMR) analysis identified that OSA is an independent risk factor for GERD, gastroduodenal ulcer, and calculus of the bile duct. The reverse MVMR analysis showed a causal effect of GERD on OSA. Besides, we did not find that the predisposition to OSA was associated with 4 cancers.ConclusionThis MR analysis provides compelling evidence of an independent causal relationship between genetically predicted OSA and an elevated risk of inflammation-related GDs. Besides, no causal association was observed between OSA and cancers. Further studies should be carried out to verify our findings.
Public perceptions and discussions of synthetic nicotine on Twitter
Authors: Chen Jiarui , He Jinxi , Xie Zidian , Li Dongmei 
Published: July 2024

BackgroundAs alternative replacement products for tobacco-derived nicotine, synthetic nicotine products have recently emerged and gained increasing popularity. This study analyzes public perception and discussion of synthetic nicotine products on Twitter (now “X”).MethodsThrough Twitter streaming API (Application Programming Interface), we have collected 2,764 Twitter posts related to synthetic nicotine from December 12, 2021, to October 17, 2022, using keywords related to synthetic nicotine. By applying an inductive approach, two research assistants manually determined the relevance of tweets to synthetic nicotine products and assessed the attitude of tweets as positive, negative, and neutral of tweets toward synthetic nicotine, and the main topics.ResultsAmong 1,007 tweets related to synthetic nicotine products, the proportion of negative tweets (383/1007, 38.03%) toward synthetic nicotine products was significantly higher than that of positive tweets (218/1007, 21.65%) with a p-value &lt;0.05. Among negative tweets, major topics include the concern about addiction and health risks of synthetic nicotine products (44.91%) and synthetic nicotine as a policy loophole (31.85%). Among positive tweets, top topics include alternative replacement for nicotine (39.91%) and reduced health risks (31.19%).ConclusionThere are mixed attitudes toward synthetic nicotine products on Twitter, resulting from different perspectives. Future research could incorporate demographic information to understand the attitudes of various population groups.
Construction of a predictive nomogram for functional recovery after Bernese periacetabular osteotomy
Authors: Du Panzhihao , Gu Yange , Jin Wenshu , Li Shufeng , Yue Yaohui , Sun Huaqiang , Yan Xinfeng 
Published: July 2024

Background and purposeSurgical indications for Bernese periacetabular osteotomy (PAO) are well-established. However, the extent of postoperative functional recovery varies widely, as observed in clinical follow-ups. Thus, preoperative evaluation is crucial. This study aims to identify factors that influence functional recovery post-PAO and to develop a predictive nomogram.Patients and methodsRetrospective data were collected between December 2016 and March 2022 at The First Affiliated Hospital of Shandong First Medical University. The dataset included demographic and imaging data of patients who underwent PAO. The least absolute shrinkage and selection operator (LASSO) regression was utilized to identify influencing factors, which were further analyzed using multivariate logistic regression to construct a predictive nomogram for post-PAO functional recovery.ResultThe analysis identified critical factors affecting functional recovery post-PAO, namely, the preoperative distance from the innermost surface of the femoral head to the ilioischial line, the surgical approach, preoperative acetabular depth, and the continuity of the preoperative Calve line. A nomogram was developed using these significant predictors. The model's validity was demonstrated by the receiver operating characteristic curve, with an area under the curve of 0.864. Additionally, the calibration curve confirmed the nomogram's accuracy, showing a strong correlation between observed and predicted probabilities, indicating high predictive accuracy.ConclusionThis predictive nomogram effectively identifies patients most suitable for PAO, providing valuable guidance for selecting surgical candidates and determining the appropriate surgical approach.
Measurement of compassion fatigue in animal health care professionals: a systematic review of available instruments and their content validity
Authors: Noe May Thet Nu , Baysal Yigit , Masserey Anaïs , Hartnack Sonja , Guseva Canu Irina 
Published: July 2024

IntroductionCompassion fatigue (CF) refers to emotional or physical exhaustion and emotional reactions resulting from prolonged exposure to traumatic events, commonly experienced by professionals in caregiving roles. CF is prevalent among healthcare professionals, including those in animal care. Several Patient-Reported Outcome Measures (PROMs) were developed to measure CF, but their psychometric validity was not reviewed systematically. This study aims to identify and review the content validity of CF PROMs used in animal health care professionals.MethodsLiterature was searched in PubMed, PsycINFO, and EMBASE (1973–2023). We included studies conducted in animal health care professionals, using a PROM to measure CF, reporting at least one psychometric property of this PROM, and published as original research. For each identified PROM, additional literature search was conducted to identify PROM development and content validation studies. Three independent reviewers evaluated the content validity of each PROM using COnsensus-based Standards for the selection of health Measurement INstruments (COSMIN) methodology and summarized the quality of evidence using a modified GRADE approach. The protocol was registered in PROSPERO (CRD42023433982) and results reported following PRISMA guidelines.ResultsInitially, 1709 studies were identified. After a double screening, 17 eligible studies were included. CF was measured using six different PROMs or their modified versions. Only one PROM specifically targeted animal health care professionals: the ProQOL-5 Veterinary Medicine Version. This and three other original CF PROMs were reviewed. For all PROMs, the quality of content validity was rated as insufficient due to deficiencies in the concept and items elicitation, inadequate target population representation, and inadequate details on cognitive interview procedures. The overall evidence quality was rated as low due to a limited number of PROM validation studies, poor methodological and reporting quality, and indirect result.DiscussionThere is a scarcity of studies examining CF within the target population, and the quality of evidence for content validity of the reviewed PROMs for CF measurement is currently low. CF definition and construct description in PROM development studies suffer from vagueness and seem inadequately reflected by the content of the reviewed PROMs. Further research with a robust methodology seems necessary to address the identified flows.Systematic review registrationMeasurement of compassion fatigue in people working with animals: protocol for a systematic review. PROSPERO 2023 CRD42023433982. Available from: https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023433982.
DNA profiles of shed Taiga Bean Goose feathers indicate between-season fidelity to moulting sites in Swedish Lapland
Authors: De Jong Adriaan , Kleven Oddmund , Honka Johanna , Vahlström Isak 
Published: July 2024

Recently, the Taiga Bean Goose Anser f. fabalis breeding population of Southern Lapland, Sweden, was shown to use a network of local sites during their summer wing moult. We used microsatellite markers to identify individual geese from DNA in shed feathers collected in 2016–2020 on six sites, enabling us to identify 168 unique individuals from 178 fully genotyped feathers. Nine individuals were represented multiple times among the collected feathers. All controls of identified individuals were made on the original site, never on an alternative site. Our results suggest a significant level of site fidelity and, thus, the need to provide a stable, low-disturbance network of moulting sites for the Southern Lapland sub-population of this endangered taxon.
Organizational and Management Innovations, Their Formalization and Effectiveness in Large Oil and Gas Corporations
Authors: Боржеш Ажеу Малундо 
Published: July 2024

В статье мы рассматриваем результативности организационно-управленческих инноваций (ОУИ) в нефтегазовых корпорациях при соблюдении критериев оптимальности. Обоснованы критерии оптимальности внедрения ОУИ и разработана система показателей оценки ОУИ на основе критериев оптимальности. Разработан методический подход к оценке результативности ОУИ на основе анализа системы критериев и показателей оценки механизма управления инновационной деятельностью.
In the article, we consider the effectiveness of organizational and management innovations (OMI) in oil and gas corporations while observing the optimality criteria. The optimality criteria of OMI implementation are substantiated and a system of indicators is developed for evaluating the OMI on the basis of the optimality criteria. A methodical approach has been developed for evaluating the effectiveness of an OMI based on an analysis of the criteria and indicators system of assessment of the innovation activity management mechanism.
Methodological Tools for Assessing the Probability of Bankruptcy of a Construction Company
Authors: Гайфуллина Марина Михайловна , Низамова Гульнара Закиевна 
Published: July 2024

В статье разработан методический инструментарий оценки вероятности банкротства строительной организации, который включает в себя оценку системы показателей риска банкротства строительной организации и расчет интегрального уровня риска банкротства по logit-модели. Предложена методика оценки значимости факторов внешней среды, влияющих на финансовое состояние строительной организации. Предложена матрица определения необходимости разработки стратегии антикризисного управления строительной организацией, основанная на совмещении интегрального уровня риска банкротства и оценки силы влияния факторов внешней среды.
The article developed a methodological tool for estimating the probability of bankruptcy of a construction organization, which includes an assessment of the system of indicators of the bankruptcy risk of a construction organization, and the calculation of the integral level of bankruptcy risk using a logit model. A method for assessing the significance of environmental factors affecting the financial condition of a construction company is proposed. A matrix is proposed for determining the need to develop a crisis management strategy for a construction organization based on combining the integral level of bankruptcy risk and assessing the impact of environmental factors.
Development of Women’s Business in Modern Russia
Authors: Райманова Зухра Ильгизовна 
Published: July 2024

В статье анализируется трактовка понятия «женское предпринимательство», рассматриваются особенности и роль женского предпринимательства в современном российском обществе. Обозначаются основные барьеры, препятствующие стремительному развитию женского предпринимательства. Предлагаются пути преодоления выявленных преград, для того чтобы женщина смогла реализовывать свои идеи и приносить пользу обществу.
The article analyzes the interpretation of the concept of «female entrepreneurship», discusses the features and the role of female entrepreneurship in modern Russian society. The main barriers to the rapid development of female entrepreneurship are indicated. Ways of overcoming the identified obstacles are proposed in order for a woman to be able to implement her ideas and bring benefits to society.