bluuebunny/crossref_metadata_2025_split huggingface dataset:
Asenapine in the treatment of older adults with bipolar disorder
Authors: Sajatovic Martha , Dines Philipp , Fuentes‐Casiano Edna , Athey Melanie , Cassidy Kristin A. , Sams Johnny , Clegg Kathleen , Locala Joseph , Stagno Susan , Tatsuoka Curtis 
Published: October 2014

ObjectiveIn spite of growing numbers of older people, there are few treatment studies on late‐life bipolar disorder (BD). This was a 12‐week prospective, open‐label trial to assess efficacy and tolerability of adjunct asenapine in non‐demented older adults (≥60 years) with sub‐optimal previous response to BD treatments.MethodsAsenapine was initiated at 5 mg/day and titrated as tolerated. Effects on global psychopathology were measured with Clinical Global Impression, bipolar version (CGI‐BP), and the Brief Psychiatric Rating Scale (BPRS). Mood polarity severity was measured with the Hamilton Depression Rating Scale, Montgomery Asberg Depression Rating Scale, and Young Mania Rating Scale. Other outcomes included the World Health Organization Disability Assessment Schedule II.ResultsFifteen individuals were enrolled (mean age 68.6, SD 6.12; 53% female; 73% Caucasian, 13% African American, and 7% Asian). There were 4/15 (27%) individuals who prematurely terminated the study, whereas 11/15 (73%) completed the study. There were significant improvements from baseline on the BPRS (p < 0.05), on CGI‐BP overall (p < 0.01), and on CGI‐BP mania (p < 0.05) and depression (p < 0.01) subscales. The mean dose of asenapine was 11.2 (SD 6.2) mg/day. The most common reported side effects were gastrointestinal discomfort (n = 5, 33%), restlessness (n = 2, 13%), tremors (n = 2, 13%), cognitive difficulties (n = 2, 13%), and sluggishness (n = 2, 13%).ConclusionsOlder people with BD had global improvements on asenapine. Most reported adverse effects were mild and transient, but adverse effects prompted drug discontinuation in just over one quarter of patients. Although risks versus benefits in older people must always be carefully considered, asenapine may be a treatment consideration for some non‐demented geriatric BD patients. Copyright © 2014 John Wiley & Sons, Ltd.
How does ageing affect the impact of medically unexplained symptoms and medically explained symptoms on health‐related quality of life?
Authors: Hilderink Peter H. , Collard Rose , Rosmalen Judith G. M. , Oude Voshaar Richard C. 
Published: October 2014

BackgroundPhysical symptoms significantly impair health‐related quality of life (HRQoL), but age effects and differential effects of medically unexplained symptoms (MUS) and medically explained symptoms (MES) have hardly been examined. Our objective was to determine the effect of age on the impact of MUS and MES on HRQoL.MethodsIn a population‐based cohort (n = 946, aged 28–75 years), MUS and MES were measured using the Composite International Diagnostic Interview and HRQoL using the EuroQol‐5 dimensions (EQ‐5D). Using multiple linear regression, we regressed MUS, MES and their interaction with age on HRQoL, adjusted for socio‐demographic variables and the presence of depressive and anxiety disorders. In case of significant interaction terms, age‐stratified results will be presented.ResultsIn the whole study population, the association between MUS and HRQoL was stronger (β = −0.35; p < 0.001) than between MES and HRQoL (β = −0.26; p < 0.001). Adjusted for depressive and anxiety disorders, differences between these associations decline (MUS: β = −0.28, p < 0.001; MES: β = −0.25, p < 0.001). Age significantly interacted with number of MUS in explaining variance in HRQoL but not with the number of MES. The impact of MUS on HRQoL is much larger in people aged below 65 years (β = −0.39, p < 0.001) versus those aged 65 years and over (β = −0.21, p = 0.002). In the older group, the association between MUS and HRQoL lost significance when adjusted for depressive and anxiety disorders (β = −0.12 p = 0.062).ConclusionOur results show that age affects the association between MUS and HRQoL, which suggest that older persons cope better with MUS than younger persons. Copyright © 2014 John Wiley & Sons, Ltd.
Endoscope‐assisted extracapsular dissection of benign parotid tumors using hairline incision
Authors: Woo Seung Hoon , Kim Jin Pyeong , Baek Chung‐Hwan 
Published: October 2014

AbstractBackgroundThis study evaluated the feasibility of endoscopic‐assisted extracapsular dissection of benign parotid tumors using only hairline incision.MethodsEndoscope‐assisted extracapsular dissection via only hairline incision was performed in 18 cases (5 men and 13 women) of benign parotid gland tumor (pleomorphic adenoma in 4 cases, Warthin's tumor in 14 cases).ResultsAll 18 operations were successfully performed and no conversions to conventional open resection were necessary. One patient had transient facial paresis and recovered within 1 month. The duration of the procedure was 82.5 ± 18.5 minutes.ConclusionEndoscope‐assisted extracapsular dissection using only hairline incision is a feasible method for treatment of benign parotid tumors. The main advantage of this procedure is that the operative scar is concealed in the hairline area. © 2015 Wiley Periodicals, Inc. Head Neck 38: 375–379, 2016
Transoral robotic approach for laryngeal schwannoma
Authors: Millas Teresa , Granell Jose , Garrido Laura , Mendez‐Benegassi Ivan , Gutierrez‐Fonseca Raimundo 
Published: October 2014

ABSTRACTBackgroundThe laryngeal schwannoma is a rare benign tumor of the larynx, most frequently found in the aryepiglottic fold, which can be rather bulky when diagnosed.MethodsWe present a primary transoral robotic surgery (TORS) for a laryngeal schwannoma and highlight the advantages of the robotic assistance.ResultsThanks to the high‐definition 3D dynamic vision and an improved freedom of movement, it is possible to accurately accomplish surgical tasks that previously were much more complex or even unfeasible through a minimally invasive approach, potentially minimizing the surgical damage.ConclusionRobotic‐assisted surgery eased excision, supporting that it can expand the indications for transoral approaches. © 2015 Wiley Periodicals, Inc. Head Neck 37: E70–E73, 2015
Carbon ion radiotherapy for locally advanced squamous cell carcinoma of the external auditory canal and middle ear
Authors: Koto Masashi , Hasegawa Azusa , Takagi Ryo , Sasahara Go , Ikawa Hiroaki , Mizoe Jun‐etsu , Jingu Keiichi , Tsujii Hirohiko , Kamada Tadashi , Okamoto Yoshitaka ,   Organizing Committee for the Working Group for Head and Neck Cancer
Published: October 2014

AbstractBackgroundThe prognosis of advanced squamous cell carcinoma (SCC) of the external auditory canal and middle ear remains poor. Carbon ion radiotherapy (C‐ion RT) has shown promise for locally advanced head and neck cancer. Therefore, we evaluated the safety and efficacy of C‐ion RT for locally advanced SCC of the external auditory canal and middle ear.MethodsThe cases of 13 patients with advanced (T3 and T4) SCC of the external auditory canal and middle ear who received C‐ion RT as the primary treatment were reviewed.ResultsThe median follow‐up for all patients and the 7 surviving patients was 12 and 32 months, respectively. The 1‐year and 3‐year local control and overall survival (OS) rates were 72% and 54% and 70% and 40%, respectively. Severe temporal bone necrosis was observed in 2 patients.ConclusionC‐ion RT is effective and generally safe for locally advanced SCC of the external auditory canal and middle ear. © 2015 Wiley Periodicals, Inc. Head Neck 38: 512–516, 2016
Patterns of care and perioperative outcomes in transoral endoscopic surgery for oropharyngeal squamous cell carcinoma
Authors: Zevallos Jose P. , Mitra Nandita , Swisher–McClure Samuel 
Published: October 2014

AbstractBackgroundTransoral endoscopic surgery is a promising new treatment for oropharyngeal squamous cell carcinoma (SCC).MethodsWe examined care patterns and outcomes in 514 patients with oropharyngeal SCC undergoing transoral endoscopic surgery within the 2010 to 2011 National Cancer Database (NCDB).ResultsMost patients had T1 to T2 tumors (88.5%), and were treated in academic facilities (64.2%). Mean length of hospitalization was 5.1 days and perioperative mortality was 0.8%. Final surgical margins were positive in 20% of patients, and were more common with T2 (odds ratio [OR] = 2.35; p < .05) or N2 disease (OR = 4.18; p < .001), treatment in community cancer centers (OR = 1.81; p < .05), and low volume centers (OR = 2.43; p < .05).ConclusionEarly adoption of transoral surgery for oropharyngeal SCC had an excellent safety profile. We observed higher rates of positive surgical margins than previously reported. These findings highlight the importance of surgeon experience and patient selection, and suggest that transoral endoscopic surgery for oropharyngeal SCC be performed by highly trained surgeons in the context of multidisciplinary care. © 2015 Wiley Periodicals, Inc. Head Neck 38: 402–409, 2016
Co‐targeting of multiple microRNAs on factor‐Inhibiting hypoxia‐Inducible factor gene for the pathogenesis of head and neck carcinomas
Authors: Kao Shou‐Yen , Tsai Meng‐Miao , Wu Cheng‐Hsieh , Chen Jing‐Jung , Tseng Ssu‐Hsueh , Lin Shu‐Chun , Chang Kuo‐Wei 
Published: October 2014

AbstractBackgroundMicroRNAs (miRNAs) are short, noncoding RNAs that inhibit the expression of target genes that play roles in tumorigenesis. MiR‐21, miR‐31, and miR‐184 are oncogenic miRNAs for head and neck squamous cell carcinoma (HNSCC). Factor‐inhibiting hypoxia (FIH)‐inducible factor is known to inactivate hypoxia‐induced downstream effectors and is involved in HNSCC suppression. This study investigates whether miR‐21, miR‐31, and miR‐184 target FIH in HNSCC.MethodsReporter assays, Western blot analysis, quantitative reverse transcriptase‐polymerase chain reaction (PCR) analysis, and phenotypic assays were used to prove that miR‐21, miR‐31, and miR‐184 directly target FIH. Clinicopathological implications of the gene expression were also analyzed.ResultsMiR‐21, miR‐31, and miR‐184 directly bind to various sites in the 3′ untranslated region (UTR) of FIH transcript, and this binding is associated with decreased FIH protein expression in HNSCC cells. Treatment with the precursors of these miRNAs increases the proliferation and migration of HNSCC cells. Concomitant treatment with precursors repressed FIH and enhanced oncogenicity most profoundly. Upregulation of miR‐21, miR‐31, and miR‐184 expression is found in more than 80% of HNSCC tumors and 72% of tumors have concordant upregulation of these 3 oncogenic miRNAs. The highest expression of these miRNAs is present in T4b and stage IVB tumors. Downregulation of FIH mRNA expression is noted in 69% of HNSCC tumors, and in tumors exhibiting high expression of these miRNAs, the FIH mRNA expression is consistently downregulated.ConclusionThis study provides novel clues indicating that miR‐21, miR‐31, and miR‐184 co‐target FIH tumor suppressor during pathogenesis in the vast majority of HNSCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 522–528, 2016
Significant preservation of swallowing function in chemoradiotherapy for advanced head and neck cancer by prophylactic swallowing exercise
Authors: Ohba Shinichi , Yokoyama Junkichi , Kojima Masataka , Fujimaki Mitsuhisa , Anzai Takashi , Komatsu Hiroaki , Ikeda Katsuhisa 
Published: October 2014

AbstractBackgroundDysphagia is a serious complication of chemoradiotherapy (CRT) in patients with head and neck cancer. Approximately 20% to 30% of patients who have dysphagia require feeding tubes. The purpose of this study was to evaluate the impact of prophylactic swallowing exercises on swallowing function.MethodsFifty‐one patients with advanced oropharyngeal, hypopharyngeal, and laryngeal cancers were included in this study. Twenty‐one patients performed the Shaker exercise and 30 practiced traditional Mendelsohn maneuvers (control group). Before and after treatment, videofluoroscopy and swallowing motion were analyzed to establish movement of the hyoid bone, larynx, and aspiration scores.ResultsAverage movement of the hyoid bone, thyrohyoid shortening, and upper esophageal sphincter opening were significantly better maintained in the Shaker group. Aspiration score of the Shaker exercise was significantly lower than control group. Feeding tube rates for the Shaker and control groups were 14% and 40% (p < .05).ConclusionShaker exercises as a prophylactic exercise contributed to preservation of swallowing function in patients with head and neck cancer. © 2015 Wiley Periodicals, Inc. Head Neck 38: 517–521, 2016
Retrospective cohort study of prognostic factors in patients with oral cavity and oropharyngeal squamous cell carcinoma
Authors: Carrillo José F. , Carrillo Liliana C. , Cano Ana , Ramirez–Ortega Margarita C. , Chanona Jorge G. , Avilés Alejandro , Herrera–Goepfert Roberto , Corona–Rivera Jaime , Ochoa–Carrillo Francisco J. , Oñate–Ocaña Luis F. 
Published: October 2014

AbstractBackgroundPrognostic factors in oral cavity and oropharyngeal squamous cell carcinoma (SCC) are debated. The purpose of this study was to investigate the association of prognostic factors with oncologic outcomes.MethodsPatients with oral cavity and oropharyngeal SCC treated from 1997 to 2012 were included in this retrospective cohort study. Associations of prognostic factors with locoregional recurrence (LRR) or overall survival (OS) were analyzed using the logistic regression and the Cox models.ResultsSix hundred thirty‐four patients were included in this study; tumor size, surgical margins, and N classification were associated with LRR (p < .0001); considering histopathology: perineural invasion, lymphocytic infiltration, infiltrative borders, and N classification were significant determinants of LRR. Tumor size, N classification, alcoholism, and surgical margins were associated with OS (p < .0001); considering pathologic prognostic factors, perivascular invasion, islands borders, and surgical margins were independently associated with OS (p < .0001).ConclusionSurgical margins, perineural and perivascular invasion, lymphocytic infiltration, and infiltrative patterns of tumor invasion are significant prognostic factors in oral cavity and oropharyngeal SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 536–541, 2016
Discussing a diagnosis of human papillomavirus oropharyngeal cancer with patients: An exploratory qualitative study of health professionals
Authors: Dodd Rachael H. , Marlow Laura A. V. , Waller Jo 
Published: October 2014

AbstractBackgroundThe role of human papillomavirus (HPV) in oropharyngeal squamous cell cancer (SCC) has now been well established. Clinicians' experiences and challenges of talking to patients about HPV have yet to be explored.MethodsFifteen health professionals caring for patients with oropharyngeal SCC were interviewed. Interviews were analyzed thematically.ResultsParticipants expressed mixed views about explaining the causal role of HPV to their patients. Normalizing HPV and emphasizing the positive prognosis associated with it were regarded as key messages to be communicated. Challenging experiences included managing couples in a consultation and patients' concerns about transmitting HPV to their partners. Some participants described limitations to their HPV knowledge and identified the need for further information and training.ConclusionThis study identified challenges experienced by health professionals working with patients with oropharyngeal SCC and highlights some key messages to convey to patients. Clinical guidance for health professionals and further information for patients about HPV‐positive oropharyngeal SCC are needed. © 2015 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck 38: 394–401, 2016
Social isolation‐induced increase in NMDA receptors in the hippocampus exacerbates emotional dysregulation in mice
Authors: Chang Chih‐Hua , Hsiao Ya‐Hsin , Chen Yu‐Wen , Yu Yang‐Jung , Gean Po‐Wu 
Published: October 2014

ABSTRACTEpidemiological studies have shown that early life adverse events have long‐term effects on the susceptibility to subsequent stress exposure in adolescence, but the precise mechanism is unclear. In the present study, mice on postnatal day 21–28 were randomly assigned to either a group or isolated cages for 8 weeks. The socially isolated (SI) mice exhibited a higher level of spontaneous locomotor activity, a longer duration of immobility in the forced swimming test (FST), significantly less prepulse inhibition (PPI) and an increase in aggressive (but not attack) behavior. However, acute stress markedly exacerbated the attack counts of the SI mice but did not affect the group housing (GH) mice. SI mice exhibited higher synaptosomal NR2A and NR2B levels in the hippocampus as compared to the GH mice. Whole‐cell patch clamp recordings of CA1 neurons in hippocampal slices showed that the SI mice exhibited a higher input‐output relationship of NMDAR‐EPSCs as compared to the GH mice. Application of the NR2B‐specific antagonist ifenprodil produced a greater attenuating effect on NMDAR‐EPSCs in slices from the SI mice. NMDAR EPSCs recorded from the SI mice had a slower deactivation kinetic. MK‐801, CPP and ifenprodil, the NMDA antagonists, reversed acute stress‐induced exaggeration of aggressive and depressive behaviors. Furthermore, acute stress‐induced exacerbation of attack behavior in the SI mice was abolished after the knockdown of NR2B expression. These results suggest that social isolation‐induced increased expression of NMDA receptors in the hippocampus involves stress exacerbation of aggressive behaviors. Amelioration of aggressive behaviors by NMDA antagonists may open a new avenue for the treatment of psychopathologies that involve outbursts of emotional aggression in neglected children. © 2014 Wiley Periodicals, Inc.
The Effect of Supplemental Dietary Fat on Plasma Cholesterol Levels in Lovastatin‐Treated Hypercholesterolemic Patients
Authors: McKenney James M. , Proctor Jack D. , Wright Jackson T. , Kolinski Robert J. , Elswick R.K. , Coaker Jean S. 
Published: October 2014

Study Objective. A validation study was conducted first to test assumptions about the effect of saturated and unsaturated dietary fat supplements. The second study was conducted to determine the effect on blood cholesterol levels of saturated and unsaturated fat supplements in patients who followed a low‐fat diet and were administered lovastatin.Design. Randomized, crossover design, with three periods in the first study and four in the second study, each lasting 6 weeks.Setting. Cholesterol Research Center.Patients. The first study evaluated adults with total cholesterol levels between 200 and 280 mg/dl (5.172 and 7.241 mmol/L). The second study included adults with low‐density lipoprotein (LDL) cholesterol levels above 160 mg/dl (4.138 mmol/L).Interventions. Fat supplements with either coconut or canola oil were delivered to patients in oatmeal‐raisin cookies.Measurements and Main Results. In the validation study, patients' mean prerandomization total cholesterol level of 222 mg/dl was reduced to 213 mg/dl with canola oil and increased to 233 mg/dl with coconut oil cookies (p=0.0038). In the second study the mean prerandomization total cholesterol level of 214 mg/dl was decreased to 199 mg/dl with canola oil and to 208 mg/dl with coconut oil cookies (p=0.2342). The LDL cholesterol levels changed in a similar fashion in both studies.Conclusions. Changes in total and LDL cholesterol levels in the validation study were expected based on established effects of saturated and unsaturated fatty acids, but changes in these levels in lovastatin‐cookie study were not expected. They could have occurred because lovastatin reversed the effect of saturated fats and enhanced the effect of unsaturated fats. Alternatively, they may have been due to enhanced bioavailability of lovastatin when administered with a high‐fat diet. These findings must be confirmed.
Age and Carotid Artery Occlusive Disease Are Important Determinants of Cerebral Blood Flow Changes After Antihypertensive Therapy
Authors: Fagan Susan C. , Levine Steven R. , Ewing James R. , Ramadan N.M. , Welch K.M.A. 
Published: October 2014

Study Objective. To determine the short‐term effects of antihypertensive therapy on cerebral blood flow (CBF).Design. Prospective, observational study.Setting. A university‐affiliated teaching hospital.Patients. Twenty‐four patients (age range 53–85 yrs) with chronic hypertension, nine of whom had carotid artery occlusive disease (CAOD).Interventions. The CBF (xenon‐133 inhalation technique) and blood pressure were measured before and at 60 minutes after administration of antihypertensive therapy.Measurements and Main Results. Age was inversely related to the change in CBF in patients with CAOD (p>0.01). In all patients, the change in CBF after taking antihypertensive drugs was significantly inversely associated with baseline CBF (p>0.01). Changes in regional CBF, measured by asymmetry scores, were significantly greater in patients with CAOD than in those without CAOD (p<0.05).Conclusions. Elderly patients with occlusive extracranial cerebrovascular disease are at risk of drug‐induced changes in both mean and regional CBF, and may benefit from a CBF assessment before being prescribed antihypertensive therapy.
Cloud‐Based Collaborative Writing and the Common Core Standards
Authors: Yim Soobin , Warschauer Mark , Zheng Binbin , Lawrence Joshua F. 
Published: October 2014

AbstractThe Common Core State Standards emphasize the integration of technology skills into English Language Arts (ELA) instruction, recognizing the demand for technology‐based literacy skills to be college‐ and career‐ ready. This study aims to examine how collaborative cloud‐based writing is used in in a Colorado school district, where one‐to‐one computer access with netbooks and open source software is provided to all students. Specifically, this paper highlights how the middle school students’ online writing align with the specific domains of the Common CoreELAStandards. Implications for practices are also discussed based on the challenges and affordances of using cloud‐based collaborative writing in the district.
Comparison of the kinetics of various biomarkers of benzo[a]pyrene exposure following different routes of entry in rats
Authors: Moreau Marjory , Bouchard Michèle 
Published: October 2014

AbstractThe effect of route of exposure on the kinetics of key biomarkers of exposure to benzo[a]pyrene (BaP), a known human carcinogen, was studied. Rats were exposed to an intravenous, intratracheal, oral and cutaneous dose of 40 µmol kg–1 BaP. BaP and several metabolites were measured in blood, urine and feces collected at frequent intervals over 72 h post‐treatment, using high‐performance liquid chromatography/fluorescence. Only BaP and 3‐hydroxyBaP (3‐OHBaP) were detectable in blood at all time points. There were route‐to‐route differences in the excreted amounts (% dose) of metabolites but the observed time courses of the excretion rate were quite similar. In urine, total amounts of BaP metabolites excreted over the 0–72 h period followed the order: trans‐4,5‐dihydrodiolBaP (4,5‐diolBaP) ≥ 3‐OHBaP > 7‐OHBaP ≥ 7,8‐diolBaP after intravenous injection and intratracheal instillation; 3‐OHBaP ≈ 7‐OHBaP ≥ 4,5‐diolBaP > 7,8‐diolBaP after cutaneous application; 3‐OHBaP ≥ 4,5‐diolBaP ≈ 7‐OHBaP > 7,8‐diolBaP following oral administration. In feces, total amounts of BaP metabolites recovered were: 7‐OHBaP ≈ 3‐OHBaP > 4,5‐diolBaP > 7,8‐diolBaP > BaP‐7,8,9,10‐tetrol following all administration routes. For all exposure routes, excretion of 4,5‐ and 7,8‐diolBaP was almost complete over the 0–24 h period in contrast with that of 3‐ and 7‐OHBaP. This study confirms the interest of measuring multiple metabolites due to route‐to‐route differences in the relative excretion of the different biomarkers and in the time courses of diolBaPs versus OHBaPs. Concentration ratios of the different metabolites may help indicate time and main route of exposure. Copyright © 2014 John Wiley & Sons, Ltd.