bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emerging biotechnologies for screening electromechanical signals of cardiomyocytes
Authors: Tang Si , Sun Lingyu , Shi Huiyao , Wang Kaixuan , Shi Jialin , Su Chanmin , Zhao Yuanjin , Liu Lianqing 
Published: July 2024

AbstractCardiac diseases threaten human health and burden the global healthcare system. Cardiomyocytes (CMs) are considered the ideal model for studying the signal transduction and regulation of cardiac systems. Based on the principle of the rhythmical beating process (excitation‒contraction coupling mechanism of CMs), investigating the mechanical and electrophysiological signals offered new hope for cardiac disease detection, prevention, and treatment. Considerable technological success has been achieved in electromechanical signal recording. However, most drug assessment platforms attach importance to high‐throughput and dynamic monitoring of mechanical or electrical signals while overlooking the measuring principles and physiological significance of the signal. In this review, the development of biosensing platforms for CMs, sensing principles, key measured parameters, measurement accuracy, and limitations are discussed. Additionally, various approaches for the stimulation and measurement of CMs in vitro are discussed to further elucidate the response of these cells to external stimuli. Furthermore, disease modeling and drug screening are used as examples to intuitively demonstrate the contribution of in vitro CM measurement platforms to the biomedical field, thereby further illustrating the challenges and prospects of these sensing platforms.
Cerebrovascular reactivity MRI as a biomarker for cerebral small vessel disease–related cognitive decline: Multi‐site validation in the MarkVCID Consortium
Authors: Liu Peiying , Lin Zixuan , Hazel Kaisha , Pottanat George , Xu Cuimei , Jiang Dengrong , Pillai Jay J. , Lucke Emma , Bauer Christopher E. , Gold Brian T. , Greenberg Steven M. , Helmer Karl G. , Jann Kay , Jicha Gregory , Kramer Joel , Maillard Pauline , Mulavelil Rachel M. , Rodriguez Pavel , Satizabal Claudia L. , Schwab Kristin , Seshadri Sudha , Singh Herpreet , Velarde Dediós Ángel G. , Wang Danny J. J. , Kalyani Rita R. , Moghekar Abhay , Rosenberg Paul B. , Yasar Sevil , Albert Marilyn , Lu Hanzhang 
Published: July 2024

AbstractINTRODUCTIONVascular contributions to cognitive impairment and dementia (VCID) represent a major factor in cognitive decline in older adults. The present study examined the relationship between cerebrovascular reactivity (CVR) measured by magnetic resonance imaging (MRI) and cognitive function in a multi‐site study, using a predefined hypothesis.METHODSWe conducted the study in a total of three analysis sites and 263 subjects. Each site performed an identical CVR MRI procedure using 5% carbon dioxide inhalation. A global cognitive measure of Montreal Cognitive Assessment (MoCA) and an executive function measure of item response theory (IRT) score were used as outcomes.RESULTSCVR and MoCA were positively associated, and this relationship was reproduced at all analysis sites. CVR was found to be positively associated with executive function.DISCUSSIONThe predefined hypothesis on the association between CVR and a global cognitive score was validated in three independent analysis sites, providing support for CVR as a biomarker in VCID.Highlights
This study measured a novel functional index of small arteries referred to as cerebrovascular reactivity (CVR).
CVR was positively associated with global cognition in older adults.
This finding was observed in three independent cohorts at three sites.
Our statistical analysis plan was predefined before beginning data collection.
Association of Mismatch Profiles and Clinical Outcome from Endovascular Therapy in Large Infarct: A Post‐Hoc Analysis of the ANGEL‐ASPECT Trial
Authors: Huo Xiaochuan , Nguyen Thanh N , Sun Dapeng , Raynald  , Pan Yuesong , Ma Gaoting , Tong Xu , Wang Mengxing , Ma Ning , Gao Feng , Mo Dapeng , Abdalkader Mohamad , Masoud Hesham E. , Nogueira Raul G. , Miao Zhongrong ,   for the ANGEL‐ASPECT study group
Published: July 2024

ObjectivesWe investigated whether patients with large infarct and the presence or absence of perfusion mismatch are associated with endovascular treatment benefit.MethodsThis is a post‐hoc analysis of the Endovascular Therapy in Anterior Circulation Large Vessel Occlusion with a Large Infarct (ANGEL‐ASPECT) randomized trial, which enrolled patients within 24 hours of onset with ASPECTS 3 to 5 or ASPECTS 0 to 2 with an infarct core 70 to 100 ml. Mismatch ratio was defined as time‐to‐maximum (Tmax) >6 s cerebral volume/ischemic core volume, and mismatch volume was defined as Tmax >6 s volume minus ischemic core volume. We divided patients into mismatch ratio ≥1.2 and mismatch volume ≥10 ml, and mismatch ratio ≥1.8 and mismatch volume ≥15 ml groups. The primary outcome was the 90‐day modified Rankin Scale score ordinal distribution. Safety outcomes were symptomatic intracranial hemorrhage and 90‐day mortality.ResultsThere were 425 patients included. In both the mismatch ratio ≥1.2 and mismatch volume ≥10 ml (mismatch+, n = 395; mismatch−, n = 31) and mismatch ratio ≥1.8 and mismatch volume ≥15 ml groups (mismatch+, n = 346; mismatch−, n = 80), better 90‐day modified Rankin Scale outcomes were found in the endovascular treatment group compared with the MM group (4 [2–5] vs 4 [3–5], common odds ratio [cOR], 1.9, 95% confidence interval [CI] 1.3–2.7, p = 0.001; 4 [2–5] vs 4 [3–5], cOR, 1.9, 95% CI 1.3–2.8, p = 0.001, respectively), but not in patients without mismatch ratio ≥1.2 and mismatch volume ≥10 ml (5 [3–6] vs 5 [4–6], cOR, 1.2, 95% CI 0.3–4.1, p = 0.83), and mismatch ratio ≥1.8 and mismatch volume ≥15 ml (4 [3–6] vs 5 [3–6], cOR, 1.2, 95% CI 0.6–2.7, p = 0.60). However, no interaction effect was found in both subgroups (p interaction >0.10).ConclusionEndovascular treatment was more efficacious than MM in patients with mismatch profiles, but no treatment effect or interaction was noted in the no mismatch profile patients. However, the small sample size of patients with no mismatch may have underpowered our analysis. A pooled analysis of large core trials stratified by mismatch is warranted. ANN NEUROL 2024;96:729–738
Outcomes of hepatocellular carcinoma patients treated in the lenvatinib and immunotherapy era (2018–2021) compared to the sorafenib era (2008–2018)
Authors: Lim Chloe A. , Amaro Carla P. , Ding Philip Q. , Cheung Winson Y. , Tam Vincent C. 
Published: July 2024

AbstractBackgroundLenvatinib (LEN) and atezolizumab + bevacizumab (A + B) have drastically changed the treatment paradigm for advanced hepatocellular carcinoma (HCC). Before these landmark trials, sorafenib (SOR) served as the standard first‐line treatment for a decade. Our study aimed to assess the outcomes of HCC patients treated during the SOR era (2008–2018) in contrast to those in the post‐SOR era (2018–2021), of which the predominant first‐line treatments were LEN or A + B.MethodsInclusion criteria of the study were all HCC patients in the Canadian province of Alberta who started first‐line systemic therapy at cancer centers between 1 January 2008 and 31 December 2021. Survival outcomes, including overall survival (OS) and progression‐free survival (PFS), along with clinician‐assessed response rate (RR), were subject to retrospective analysis.ResultsOf 372 total patients, 230 received treatment in the SOR era and 142 in the post‐SOR era. The demographic and clinical characteristics for the SOR era and post‐SOR era groups are as follows, respectively: the median age was 63 and 64 years, 80% and 81% were male, and 24% and 11% were of East Asian ethnicity. Before receiving systemic treatment, 40% and 33% received TACE, 7% and 9% received TARE, and 3% and 14% received SBRT in the two eras, respectively. In the post‐SOR era, patients received A + B (23%), LEN (51%), and SOR (23%) as first‐line treatment. There was a statistically significant improvement in RR (15% vs. 26%; p = 0.02), median PFS (3.8 months vs. 7.9 months; p < 0.0001), and median OS (9.8 months vs. 17.0 months; p < 0.0001).ConclusionsIn this retrospective multicenter real‐world study, HCC patients treated in the post‐SOR era, where LEN and A + B were commonly used first‐line treatments, exhibited superior OS, PFS, and RR compared to patients treated in the SOR era. The findings of this study affirm the tangible progress achieved in the real world in enhancing outcomes for HCC patients through advancements in treatments over the past 15 years.
Golgi protein ACBD3 downregulation sensitizes cells to ferroptosis
Authors: Qian Ying , Ma Shanchuan , Qiu Rong , Sun Zhiyang , Liu Wei , Wu Fan , Lam Sin Man , Xia Zhengguo , Wang Kezhen , Fang Linshen , Shui Guanghou , Cao Xinwang 
Published: July 2024

AbstractFerroptosis, a form of cell death driven by iron‐dependent lipid peroxidation, is emerging as a promising target in cancer therapy. It is regulated by a network of molecules and pathways that modulate lipid metabolism, iron homeostasis and redox balance, and related processes. However, there are still numerous regulatory molecules intricately involved in ferroptosis that remain to be identified. Here, we indicated that suppression of Golgi protein acyl‐coenzyme A binding domain A containing 3 (ACBD3) increased the sensitivity of Henrieta Lacks and PANC1 cells to ferroptosis. ACBD3 knockdown increases labile iron levels by promoting ferritinophagy. This increase in free iron, coupled with reduced levels of glutathione peroxidase 4 due to ACBD3 knockdown, leads to the accumulation of reactive oxygen species and lipid peroxides. Moreover, ACBD3 knockdown also results in elevated levels of polyunsaturated fatty acid‐containing glycerophospholipids through mechanisms that remain to be elucidated. Furthermore, inhibition of ferrtinophagy in ACBD3 downregulated cells by knocking down the nuclear receptor co‐activator 4 or Bafilomycin A1 treatment impeded ferroptosis. Collectively, our findings highlight the pivotal role of ACBD3 in governing cellular resistance to ferroptosis and suggest that pharmacological manipulation of ACBD3 levels is a promising strategy for cancer therapy.
Mesoionic Janus‐Type Dicarbene: Complexes, Adducts, and Catalytic Studies
Authors: Leung Jia Nuo , Huynh Han Vinh 
Published: July 2024

AbstractThe preparations of homo‐ and hetero‐bimetallic complexes as well as thiourea and selenourea derivatives of a mesoionic Janus‐type N‐heterocyclic dicarbene (diNHC) are reported. Analogues of its monocationic intermediate NHC have also been obtained for comparison. Using the main group adducts, the π‐acceptor properties of both NHCs were determined using low temperature 77Se NMR spectroscopy completing their stereoelectronic profiling. Moreover, catalytic investigations reveal that the mesoionic dipalladium Janus‐diNHC complex can be used in the sequential C2‐ and C5‐arylation of 1‐methylpyrrole for the preparation of non‐symmetrical 2,5‐diarylpyrroles.
Collaborative entrepreneurship and social innovation performance: Effects of institutional support and social legitimacy
Authors: Adomako Samuel , Nguyen Nguyen Phong 
Published: July 2024

AbstractTo date, our understanding of how collaborative entrepreneurship influences social innovation performance is limited. In this article, we developed and tested a model that examines the effect of collaborative entrepreneurship on social innovation performance and introduced two boundary conditions of this relationship. Time‐lag data collected from 261 entrepreneurial firms in Vietnam yielded the following results. First, collaborative entrepreneurship positively influences social innovation. Second, institutional support boosts the effect of collaborative entrepreneurship on social innovation performance. Finally, the effect of collaborative entrepreneurship on social innovation performance is contingent on social legitimacy such that at high levels of social legitimacy, the effect of collaborative entrepreneurship on social innovation performance is amplified. These findings contribute to the collaborative entrepreneurship and social innovation literature and offer implications for practice.
A Highly Efficient Electrosynthesis of Formaldehyde Using a TEMPO‐Based Polymer Electrocatalyst
Authors: Broersen P. J. L. , Koning J. J. N. , Rothenberg G. , Garcia A. C. 
Published: July 2024

AbstractIn the chemical industry, formaldehyde is an important bulk chemical. The traditional synthesis of formaldehyde involves an energy intensive oxidation of methanol over a metal oxide catalyst. The selective electrochemical oxidation of methanol is challenging. Herein, we report a catalytic system with an immobilized TEMPO electrode that selectively oxidizes methanol to formaldehyde with high turnover numbers. Upon the addition of various organic and inorganic bases, the activity of the catalyst could be tuned. The highest Faradaic efficiency that was achieved was 97.5 %, the highest turnover number was 17100. Additionally, we found that the rate determining step changed from the step in which the carbonyl specie is created from the methanol‐TEMPO adduct to the oxidative regeneration of the TEMPO+ species. Finally, we showed that the system could be applied to the oxidation of other aliphatic alcohols.
Low‐intensity pulsed ultrasound improves myocardial ischaemia‒reperfusion injury via migrasome‐mediated mitocytosis
Authors: Sun Ping , Li Yifei , Yu Weidong , Chen Jianfeng , Wan Pingping , Wang Zhuo , Zhang Maomao , Wang Chao , Fu Shuai , Mang Ge , Choi Stephen , Du Zhuo , Tang Caiying , Li Song , Shi Guoxia , Tian Jiawei , Dai Jiannan , Leng Xiaoping 
Published: July 2024

AbstractDuring myocardial ischaemia‒reperfusion injury (MIRI), the accumulation of damaged mitochondria could pose serious threats to the heart. The migrasomes, newly discovered mitocytosis‐mediating organelles, selectively remove damaged mitochondria to provide mitochondrial quality control. Here, we utilised low‐intensity pulsed ultrasound (LIPUS) on MIRI mice model and demonstrated that LIPUS reduced the infarcted area and improved cardiac dysfunction. Additionally, we found that LIPUS alleviated MIRI‐induced mitochondrial dysfunction. We provided new evidence that LIPUS mechanical stimulation facilitated damaged mitochondrial excretion via migrasome‐dependent mitocytosis. Inhibition the formation of migrasomes abolished the protective effect of LIPUS on MIRI. Mechanistically, LIPUS induced the formation of migrasomes by evoking the RhoA/Myosin II/F‐actin pathway. Meanwhile, F‐actin activated YAP nuclear translocation to transcriptionally activate the mitochondrial motor protein KIF5B and Drp1, which are indispensable for LIPUS‐induced mitocytosis. These results revealed that LIPUS activates mitocytosis, a migrasome‐dependent mitochondrial quality control mechanism, to protect against MIRI, underlining LIPUS as a safe and potentially non‐invasive treatment for MIRI.
Higher thermal plasticity in flowering phenology increases flowering output
Authors: Kotilainen Aino , Mattila Anniina L. K. , Møller Charlotte , Koivusaari Susanna , Hyvärinen Marko‐Tapio , Hällfors Maria H. 
Published: July 2024

AbstractOngoing climate change poses an increasing threat to biodiversity. To avoid decline or extinction, species need to either adjust or adapt to new environmental conditions or track their climatic niches across space. In sessile organisms such as plants, phenotypic plasticity can help maintain fitness in variable and even novel environmental conditions and is therefore likely to play an important role in allowing them to survive climate change, particularly in the short term. Understanding a species' response to rising temperature is crucial for planning well‐targeted and cost‐effective conservation measures. We sampled seeds of three Hypericum species (H. maculatum, H. montanum, and H. perforatum), from a total of 23 populations originating from different parts of their native distribution areas in Europe. We grew them under four different temperature regimes in a greenhouse to simulate current and predicted future climatic conditions in the distribution areas. We measured flowering start, flower count, and subsequent seed weight, allowing us to study variations in the thermal plasticity of flowering phenology and its relation to fitness. Our results show that individuals flowered earlier with increasing temperature, while the degree of phenological plasticity varied among species. More specifically, the plasticity of H. maculatum varied depending on population origin, with individuals from the leading range edge being less plastic. Importantly, we show a positive relationship between higher plasticity and increased flower production, indicating adaptive phenological plasticity. The observed connection between plasticity and fitness supports the idea that plasticity may be adaptive. This study underlines the need for information on plasticity for predicting species' potential to thrive under global change and the need for studies on whether higher phenotypic plasticity is currently being selected as natural populations experience a rapidly changing climate.
One‐Pot Synthesis of a Tetrasaccharide Repeating Unit of O‐Antigen from Escherichia Coli O33
Authors: Sun Ao , Zheng Jiayi , Li Zipeng , Zhao Wenjian , Zhang Xiao , Yao Wang , Li Zhongjun 
Published: July 2024

AbstractA tetrasaccharide repeating unit of the O‐antigen from Escherichia coli O33 has been synthesized for the first time using a chemoselective [1+1+2] one‐pot glycan assembly strategy. The phosphoglycerol moiety was installed by using the phosphoramidite method with benzylidene‐protected glycerol 2‐phosphoramidite as the reagent. Overall, the target tetrasaccharide was synthesized from monosaccharide building blocks in 12 linear steps, resulting in a satisfactory yield of 28 %.
Fault detection and classification in overhead transmission lines through comprehensive feature extraction using temporal convolution neural network
Authors: Tunio Nadeem Ahmed , Hashmani Ashfaque Ahmed , Khokhar Suhail , Tunio Mohsin Ali , Faheem Muhammad 
Published: July 2024

AbstractFaults in transmission lines cause instability of power system and result in degrading end users sophisticated equipment. Therefore, in case of fault and for the quick restoration of problematic phases, reliable and accurate fault detection and classification techniques are required to categorize the faults in a minimum time. In this work, 500 kV transmission line (Jamshoro‐New Karachi), Sindh, Pakistan has been modeled in MATLAB. The discrete wavelet transform (DWT) has been used to extract features from the transient current signal for different faults in 500 kV transmission line under various parameters such as fault location, fault inception angle, ground resistance and fault resistance and time series data has been obtained for fault classification. Moreover, the temporal convolutional neural network (TCN) is used for fault classification in 500 kV transmission network due to its robust framework. From simulation results, it is found that faults in 500 kV transmission line are classified with 99.9% accuracy. Furthermore, the simulation results of the TCN model compared to bidirectional long short‐term memory (BiLSTM) and Gated Recurrent Unit (GRU) and it has been found that TCN model is capable of classifying faults in 500 kV transmission line with high accuracy due to its ability to handle long receptive field size, less memory requirement and parallel processing due to dilated causal convolutions. Through this work, the meantime to repair of 500 kV transmission line can be reduced.
Oil and gas development influences potential for dust emission from the Upper Colorado River Basin, USA
Authors: Tyree Gayle L. , Chappell Adrian , Villarreal Miguel L. , Dhital Saroj , Duniway Michael C. , Edwards Brandon L. , Faist Akasha M. , Nauman Travis W. , Webb Nicholas P. 
Published: July 2024

AbstractWind erosion and dust emission from drylands have large consequences for ecosystem function and human health. Wind erosion is naturally reduced by soil crusting and sheltering by non‐erodible roughness elements such as plants. Land uses that reduce surface roughness and disturb the soil surface can dramatically increase dust emission. Extraction of oil and gas is a common and growing land use in the western United States (US) that removes vegetation and other roughness elements for construction of well pads and unpaved access roads, resulting in thousands of small (1–4 ha), discrete patches of unprotected soil. Here, we use a satellite albedo‐based model to assess the effect of oil/gas activity on surface roughness in the Uinta‐Piceance Basin, an area of the Upper Colorado River Basin (UCRB) with dense oil and natural gas development and modelled how the change in surface roughness could impact aeolian sediment flux and dust emission. We also investigated how regional drought influences the response of surface roughness to well pads and access roads. Oil/gas activity reduced surface roughness and increased modelled aeolian sediment flux at the landscape scale across much of the study region, resulting in a modest increase of 10 139 kg of dust per year, which is small relative to dust loads from a single regional dust event observed in the region, but downwind impact could be significant. The magnitude of surface roughness reductions by oil/gas activity was generally consistent among land cover types. However, in parts of the basin that had high cover of annual forbs and grasses, oil/gas activity was associated with larger surface roughness and smaller potential dust emission. Drought decreased surface roughness across disturbed and undisturbed sites, but there was no interactive effect of oil/gas activity and drought on surface roughness. These results suggest that oil/gas activity may increase sediment fluxes and likely contributes to dust emission from landscapes in the UCRB. Understanding how drought and land use change contribute to dust emissions will benefit mitigation of undesirable impacts of wind erosion and dust transport.
Well‐defined nanostructures of high entropy alloys for electrocatalysis
Authors: Chen Jie , Ren Liping , Chen Xin , Wang Qi , Chen Chunying , Fan Jinpeng , Wang Shuai , Binas Vasileios , Shen Shaohua 
Published: July 2024

AbstractHigh‐entropy alloys (HEAs) have attracted significant attention for electrocatalytic energy conversion by virtue of their promisingly high efficiency, stability, and low cost. Recently, encouraging progress has been made in tuning the structure and composition of HEAs used in electrolyzers and fuel cells. However, the understanding on the synthetic methods and the structure‐property‐performance relationship of well‐defined HEAs nanostructures is still inadequate. To gain insight into the future research directions on HEAs for electrocatalysis, in this paper, the synthetic methods commonly used to obtain well‐defined HEAs nanostructures (0D nanoparticles, 1D nanowires, 2D nanosheets/nanoplates, 3D nanoporous structures, and other three‐dimensional morphologies) are first summarized. Then, the authors discuss the application of well‐defined HEAs nanostructures in several typical electrocatalytic reactions, including hydrogen evolution reaction, oxygen evolution reaction, oxygen reduction reaction, alcohol oxidation reaction, carbon dioxide reduction reaction, nitrogen reduction reaction, and formic acid oxidation reaction. Finally, a practical perspective on the future research directions on well‐defined HEAs nanostructured electrocatalysts is provided.