bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Negative Coregulator for the Human ER
Authors: Norris John D. , Fan Daju , Sherk Andrea , McDonnell Donald P. 
Published: January 2014

AbstractERα is a ligand-activated transcription factor and a key regulator of the processes involved in cellular proliferation and differentiation. In addition, aberrant ERα activity is linked to several pathological conditions including breast cancer. A complex network of coregulatory proteins is largely believed to determine the transcriptional activity of ERα. We report here the isolation of a protein, denoted RTA for repressor of tamoxifen transcriptional activity, which contains an RNA recognition motif and interacts with the receptor N-terminal activation domain. RTA interacts with RNA in vitro, and its overexpression inhibits the partial agonist activity manifest by the antiestrogen tamoxifen while minimally affecting E2-activated transcription. Mutation of the RNA recognition motif alters RNA binding specificity and results in a dominant negative form of RTA that leads to derepression of ERα transcriptional activity, allowing all classes of antiestrogens to manifest partial agonist activity and enhancing agonist efficacy. These findings suggest a role for RNA binding proteins as coregulatory factors of the nuclear receptor family and reveal a novel mechanism by which antiestrogens can manifest agonist activities in some tissues.
Inhibition of the Dihydrotestosterone-Activated Androgen Receptor by Nuclear Receptor Corepressor
Authors: Cheng Shinta , Brzostek Sabrina , Lee Suzanne R. , Hollenberg Anthony N. , Balk Steven P. 
Published: January 2014

AbstractNuclear receptor corepressor (NCoR) mediates transcriptional repression by unliganded nuclear receptors and certain steroid hormone receptors (SHRs) bound to nonphysiological antagonists, but has not been found to regulate SHRs bound to their natural ligands. This report demonstrates that NCoR interacts directly with the androgen receptor (AR) and represses dihydrotestosterone-stimulated AR transcriptional activity. The NCoR C terminus, containing the receptor interacting domains, was necessary for repression, which was ablated by mutations in the corepressor nuclear receptor (CoRNR) boxes. In contrast, the NCoR N terminus, containing domains that can recruit histone deacetylases, was not necessary for repression. Binding studies in vitro with a series of glutathione-S-transferase-NCoR and -AR fusion proteins demonstrated a direct interaction that was similarly dependent upon the NCoR corepressor nuclear receptor boxes and AR ligand binding domain and was independent of ligand and helix 12 in the AR ligand binding domain. This NCoR-AR interaction was further demonstrated in mammalian two-hybrid assays and by coimmunoprecipitation of the endogenous proteins from a prostate cancer cell line. Finally, AR transcriptional activity could be enhanced in vivo by sequestration of endogenous NCoR with unliganded thyroid hormone receptor. These results demonstrate that AR, in contrast to other SHRs, is regulated by NCoR and suggest the possibility of developing selective AR modulators that enhance this interaction.
"The only beauty is truth that become visible" (Urban sculpture as the factor of ethnical and civil identity construction in post-Soviet societies)
Authors: Аманжолова Дина , Amanzholova Dina 
Published: January 2014

Author presents comparative analysis of urban sculpture in Kiev and Astana as important factors for construction of ethnical and civil identity in post-Soviet reality. Particular attention is paid to disbalance and continuity of present life with Soviet past, specifi cs and contradiction of ethno-social and cultural politics of Ukraine and
Kazakhstan, sculpture plastics as the element of modern urban area for basic components of public conscience formation and value reference points of complex system of self-identifi cation in post-Soviet societies.
Physical and Chemical Compatibility of Injectable Acetaminophen during Simulated Y-Site Administration
Authors: Anderson Collin , Boehme Sabrina , Ouellette Jacquelyn , Stidham Chanelle , MacKay Mark 
Published: January 2014

Purpose The physical and chemical compatibility of intravenous acetaminophen with commonly administered injectable medications was evaluated. Methods Simulated Y-site evaluation was accomplished by mixing 2 mL of acetaminophen (10 mg/mL) with 2 mL of an alternative intravenous medication and subsequently storing the mixture in a polypropylene syringe for 4 hours. The aliquot solutions were visually inspected and evaluated for crystal content at 4 hours by infusing 4 mL of the medication mixture through a 0.45-μm nitrocellulose filter disc. Medication mixtures that were selected for chemical stability testing were analyzed by high-performance liquid chromatography at 0, 1, and 4 hours using a Zorbax Eclipse Plus C18, 4.6 × 100 mm, 3.5-μm column for separation of analytes with subsequent diode-array detection. Medications were considered chemically compatible if the concentrations of all components were >90% of the original concentrations during the 4 hour simulated Y-site compatibility test. Results U.S. Pharmacopeial Convention (USP) standards for physical particle counts were met for acetaminophen injection (10 mg/mL) when combined with cefoxitin, ceftriaxone, clindamycin, dexamethasone, diphenhydramine, dolasetron, fentanyl, granisetron, hydrocortisone, hydromorphone, ketorolac, meperidine, methylprednisolone, midazolam, morphine, nalbuphine, ondansetron, piperacillin/tazobactam, ranitidine, and vancomycin. Injectable acetaminophen is incompatible with acyclovir and diazepam and therefore should not be administered concomitantly with either of these products. Further testing confirmed the chemical compatibility of acetaminophen with ceftriaxone, diphenhydramine, granisetron, ketorolac, nalbuphine, ondansetron, piperacillin/tazobactam, and vancomycin. Conclusion All medications tested with acetaminophen were physically compatible except for acyclovir and diazepam. All 8 medications tested for chemical compatibility with acetaminophen were stable over the 4 hour simulated Y-site administration study.
Der Glaube an die Wissenschaften und der methodische Atheismus – Zur religiösen Dialektik der wissenschaftlich-technischen Zivilisation
Authors: Tetens Holm 
Published: January 2014

Zusammenfassung
In der wissenschaftlich-technischen Zivilisation verbindet sich ein Glaube an die Realitätsbeschreibung durch die Wissenschaften mit der Hoffnung auf eine ungehemmte Verbesserung der Welt mit Hilfe einer wissenschaftsbasierten Technik. Der Aufsatz versucht herauszuarbeiten, wie diese Verbindung wesentlich einen methodischen Atheismus und ein Projekt der Selbsterlösung des Menschen einschließt und wie dadurch der Glaube an die Wissenschaften und die Weltverbesserungshoffnung in eine dialektische Spannung zueinander geraten, die in ihrer Tiefendimension religiös ist.
Phase-Amplitude Coupling in Rat Orbitofrontal Cortex Discriminates between Correct and Incorrect Decisions during Associative Learning
Authors: van Wingerden Marijn , van der Meij Roemer , Kalenscher Tobias , Maris Eric , Pennartz Cyriel M.A. 
Published: January 2014

Cross-frequency interactions between oscillations in local field potentials (LFPs) are thought to support communication between brain structures by temporally coordinating neural activity. It is unknown, however, whether such interactions differentiate between different levels of performance in decision-making tasks. Here, we investigated theta (4–12 Hz) to gamma (30–100 Hz) phase-amplitude coupling in LFP recordings from rat orbitofrontal cortex. Across subsequent periods of a task in which rats learned to discriminate two odors associated with positive and negative outcomes, theta-to-gamma phase-amplitude coupling (PAC) was highest during the odor-sampling task period that preceded a Go/NoGo decision. This task-dependent modulation could not be explained by changes in oscillatory power and appeared to be time-locked to odor onset, not to the timing of the behavioral response. We found that PAC strength during odor sampling correlated with learning, as indexed by improved performance across trials. Moreover, this increase in PAC magnitude was apparent only on trials with correct Go and NoGo decisions, but not incorrect Go decisions. In addition, we found that PAC preferred coupling phase showed consistency over sessions only for correct, but not incorrect trials.In conclusion, orbitofrontal cortex theta-gamma PAC strength differentiates between different levels of performance in an olfactory decision-making task and may play a role in the generation and utilization of stimulus-based outcome predictions, necessary for adaptive decision-making.
Serum levels of the myokine irisin in relation to metabolic and renal function
Authors: Ebert Thomas , Focke Denise , Petroff David , Wurst Ulrike , Richter Judit , Bachmann Anette , Lössner Ulrike , Kralisch Susan , Kratzsch Jürgen , Beige Joachim , Bast Ingolf , Anders Matthias , Blüher Matthias , Stumvoll Michael , Fasshauer Mathias 
Published: January 2014

ObjectiveIrisin has recently been introduced as a novel myokine which reverses visceral obesity and improves glucose metabolism in mice. However, regulation of irisin in humans in relation to renal and metabolic disease has not been comprehensively studied.Design and methodsSerum irisin levels were quantified by ELISA and correlated with anthropometric and biochemical parameters of renal function, glucose and lipid metabolism, as well as inflammation, in 532 patients with stages 1–5 of chronic kidney disease (CKD).ResultsMedian serum irisin levels adjusted for age, gender, and BMI significantly decreased with increasing CKD stage and lowest concentrations were seen in patients with CKD stage 5. Furthermore, irisin concentrations were associated with facets of the metabolic syndrome including diastolic blood pressure, markers of impaired glucose tolerance, and dyslipidemia in univariate analysis. Moreover, markers of renal function, e.g. glomerular filtration rate, and insulin resistance, e.g. homeostasis model assessment of insulin resistance, remained independently associated with circulating irisin levels in robust multivariate analysis.ConclusionsWe show that irisin serum concentrations decrease with increasing CKD stage and are independently and positively predicted by renal function and insulin resistance. The physiological relevance of our findings, as well as the factors contributing to irisin regulation in humans, needs to be further defined in future experiments.
On the dynamics of a vaccination model with multiple transmission ways
Authors: Liao Shu , Yang Weiming 
Published: January 2014

Abstract
In this paper, we present a vaccination model with multiple transmission ways and derive the control reproduction number. The stability analysis of both the disease-free and endemic equilibria is carried out, and bifurcation theory is applied to explore a variety of dynamics of this model. In addition, we present numerical simulations to verify the model predictions. Mathematical results suggest that vaccination is helpful for disease control by decreasing the control reproduction number below unity.
Landmark-Based Morphometric Study in the Fore and Hind Wings of an Iranian Race of European Honeybee (Apis mellifera meda)
Authors: Dolati Lotfali , Rafie Javad Nazemi , Khalesro Hoda 
Published: January 2014

Abstract
Honeybee (Apis mellifera ) populations are usually distinguished using standard morphometric methods, mainly based on multivariate analysis of distances and angles. Recently, geometric morphometrics, another method of statistical analysis of shape, has been developed. This research was conducted on European honeybees in Iran in 2012. Multivariate analysis on hind wings identified significant differences between honeybee populations from different areas and significant differences in centroid size of fore wings in different geographical areas (F = 10.6, p = 0.000). Populations from nine areas were classified using discriminate function analysis based on shape variables of fore and hind wings. Crossvalidation tests based on discriminant functions of front wings correctly classified 68.2% of the colonies, and cross-validation tests based on discriminant functions of hind wings correctly classified 43% of the colonies.
Unusual complication of ventriculoperitoneal shunt
Authors: Ojo Omotayo A. , Elebute Olumide , Kanu Okezie O. , Popoola Olusegun Adebisi 
Published: January 2014

Abstract
Ventriculoperitoneal shunt (VPS) is the conventional method of managing hydrocephalus until recently that endoscopic third ventriculostomy is becoming popular. The major disadvantage of VPS is the fact that it constitutes a foreign body and prone to complications such as mechanical blockage, shunt infection, shunt migration and rarely shunt protrusion. Shunt extrusion through the vagina and anus are rare but have been documented. We present a rare case of shunt migrating through the external inguinal ring into the scrotal sac in a patient.
Extramedullary Myxopapillary Ependymoma of the Filum Terminale Associated With Syringomyelia: A Case Report
Authors: Samanci Yavuz , Celik Suat Erol 
Published: January 2014

Abstract
Aim: Ependymomas compose the majority of all intradural intramedullary spinal lesions. Filum terminale lesions are rarely associated with syringomyelia. Here we describe a case of extramedullary myxopapillary ependymoma associated with extensive syringomyelia located in the filum terminale.
Material and Methods: A 34-year-old man admitted to our clinic with complaints of bilateral leg weakness, back pain and urinary dysfunction. The magnetic resonance imaging (MRI) of the patient showed us a contrast enhanced intraspinal mass at the level of L2 with a syringomyelia extending from L2 level to Th7 level.
Results: The patient was operated via lumbar laminoplasty and tumor was totally resected.
Conclusion: The removal of tumor is also sufficient for the resolution of syringomyelia and no additional procedure is essential for the treatment of syringomyelia in such cases. This is the first case of extramedullary tumors of the cauda equine with extensive syringomyelia.
A FEW NOTES ON THE LANGUAGE OF EU ANTITRUST LAW IN ENGLISH-POLISH TRANSLATION
Authors: Piszcz Anna 
Published: January 2014

Abstract
In this paper I would like to present a brief description of the issues in English-Polish translation in the field of antitrust. Ever since Poland became a part of the broadening European integration, the Polish antitrust laws have been strongly “Europeanised”. Many new linguistic elements exist in both the Polish language of antitrust law and Polish legal language. Whatever the cause, the result is a decrease in the quality of the language. The issues of concern are divided into two groups. The first relates to producing Polish versions of EU legal documents concerning antitrust (part 2 of the paper). The second is related to translating English language of antitrust for the purposes of drafting national documents concerning antitrust, both legal documents and documents that are not legally binding (part 3 of the paper). I will then (in part 4 of the paper) turn to areas where a change is needed and propose measures that might be helpful in the current circumstances.
La pluriactivité des marins du long cours au XVIIIe siècle.
Authors: Sauzeau Thierry 
Published: January 2014

À la fin du xviiie siècle, un millier de gens de mer habitent autour de l’estuaire de la Seudre, une zone rurale et maritime. Ils travaillent comme salariés du grand commerce, à La Rochelle et Bordeaux mais passent souvent plus de la moitié de leur vie à terre. C’est grâce à l’étude des archives des notaires que l’on peut étudier leur mode de vie, a travers l’organisation de leurs maisons, la nature de leurs stocks et de l’outillage qu’ils possèdent. Les activités de second plan suivent la hiérarchie sociale. Les plus pauvres pratiquent la pêche côtière, les plus riches exploitent des terres, les catégories intermédiaires font du commerce. Pour tous, la diversification de l’activité passe par deux marqueurs principaux : l’exploitation de la vigne et le travail du bois. Quel que soit leur niveau social, tous les marins de la Seudre sont concernés, ce qui constitue une particularité de ce monde maritime dans la France de la fin du xviiie siècle.
Les gens de mer du quartier de Marennes et l’institution des invalides de la Marine (milieu XVIIIe-milieu XIXe siècle)
Authors: Sauzeau Thierry 
Published: January 2014

Pendant le règne de Louis XIV, la monarchie française essaie de mettre en place un nouveau système de recrutement des marins de la flotte de guerre : le système des classes. Les marins résistent à ce projet et Colbert doit leur offrir des contreparties. Parmi elles, figure l'institution des invalides, pour les marins âgés ou blessés. Alimentée par des cotisations sur les salaires des pêcheurs et des matelots du commerce, une caisse organise les secours pour les invalides. En suivant les générations de marins inscrits dans le quartier de Marennes (France, Charente-maritime) entre 1760 et 1825, cette communication montre qu'il a fallu attendre plus d'un siècle pour voir cette organisation fonctionner correctement, à la veille de la Révolution. Au xixe siècle, la croissance des pêches et des navigations côtières permet l'attribution de secours à ceux qui en ont besoin, avant une remise en question à la fin du siècle.
Cervical Spinal Cord Injury at the Victorian Spinal Cord Injury Service: Epidemiology of the Last Decade
Authors: Lau Simon C.P. , Myhill Nathan G. , Ganeshalingam Rekha , Quan Gerald M.Y. 
Published: January 2014

Introduction Cervical spinal cord injury (CSCI) is a significant medical and socioeconomic problem. In Victoria, Australia, there has been limited research into the incidence of CSCI. The Austin Hospital's Victorian Spinal Cord Injury Service (VSCIS) is a tertiary referral hospital that accepts referrals for surgical management and ongoing neurological rehabilitation for south eastern Australia. The aim of this study was to characterise the epidemiology of CSCI managed operatively at the VSCIS over the last decade, in order to help fashion public health campaigns. Methods This was a retrospective review of medical records from January 2000 to December 2009 of all patients who underwent surgical management of acute CSCI in the VSCIS catchment region. Patients treated non-operatively were excluded. Outcome measures included: demographics, mechanism of injury and associated factors (like alcohol) and patient neurological status. Results Men were much more likely to have CSCI than women, with a 4:1 ratio, and the highest incidence of CSCI for men was in their 20s (39%). The most common cause of CSCI was transport related (52%), followed by falls (23%) and water-related incidents (16%). Falls were more prevalent among those >50 years. Alcohol was associated in 22% of all CSCIs, including 42% of water-related injuries. Discussion Our retrospective epidemiological study identified at-risk groups presenting to our spinal injury service. Young males in their 20s were associated with an increased risk of transport-related accidents, water-related incidents in the summer months and accidents associated with alcohol. Another high risk group were men >50 years who suffer falls, both from standing and from greater heights. Public awareness campaigns should target these groups to lower incidence of CSCI.
Oral Microbial Flora in Health
Authors: Sanketh DS , Amrutha N 
Published: January 2014

ABSTRACTThe oral lora comprises of plethora of microorganisms with a predominance of bacteria. These organisms are beneficial when present in right numbers. The oral cavity harbors a variety of habitats with varying environmental conditions, making the study of oral microbiology complex and difficult. Hence, a sound knowledge of the normal commensals of the oral cavity is an essential tool for accurate laboratory diagnosis. The objective of this article is to benefit the student population as the concept of oral microbial lora has been put forward in a simplified format.How to cite this articlePatil S, Rao RS, Amrutha N, Sanketh OS. Oral Microbial Flora in Health. World J Oent 2013;4(4): 262-266.
Molecular Rotors in Porous Organic Frameworks
Authors: Comotti Angiolina , Bracco Silvia , Ben Teng , Qiu Shilun , Sozzani Piero 
Published: January 2014

AbstractPorous organic frameworks perform a variety of functions, owing to their extremely large surface areas, but the dynamics of the structural elements have never been explored. Our discovery of ultra‐fast molecular rotors (106 Hz at 225 K) in their architectures allows us to look at them from a new perspective. The constructive elements are robust struts and rapid rotors, resulting in a dynamic material whose motion can be frozen or released at will. The rotational motion can be actively regulated in response to guests. As the temperature is increased, the rotors spin ever faster, approaching free‐rotational diffusion at 550 K. The unusual combination of remarkable nanoporosity with fast dynamics is intriguing for engineering oscillating dipoles and producing responsive materials with switchable ferroelectricity, and for applications spanning from sensors to actuators, which capture and release chemicals on command.
Asymmetric NH Insertion of Secondary and Primary Anilines under the Catalysis of Palladium and Chiral Guanidine Derivatives
Authors: Zhu Yin , Liu Xiaohua , Dong Shunxi , Zhou Yuhang , Li Wei , Lin Lili , Feng Xiaoming 
Published: January 2014

AbstractEfficient enantioselective NH insertion reactions of secondary and primary anilines were catalyzed by palladium(0) in combination with chiral guanidine derivatives. A broad range of substituted anilines were tolerated, and the corresponding products were obtained in high yield (up to 99 %) with good enantioselectivity (up to 94 % ee) under mild reaction conditions. The NH insertion mechanism was examined by the study of kinetic isotope effects, control experiments, HRMS, and spectroscopic analysis.
Crystallization behavior of spray‐dried and freeze‐dried graphene oxide/poly(trimethylene terephthalate) composites
Authors: Guo Chengxin , Ji Liangliang , Li Yaowen , Yang Xiaoming , Tu Yingfeng 
Published: January 2014

ABSTRACTTwo types of graphene oxide (GO) powders were prepared by freeze‐drying or spray‐drying method, and their composites with poly(trimethylene terephthalate) (PTT) were prepared by melt blending. The influence of GO powders' type and content on crystallization behavior of PTT was investigated by differential scanning calorimeter (DSC) and polarized optical microscopy (POM). DSC results indicated that the overall crystallization rate of PTT was accelerated by well‐dispersed GO material which acts as a heterogeneous nucleation agent, since the Avrami parameter obtained is near 3. On the contrary, large GO aggregates which is in the minority will hinder the nucleation. Interestingly, large and well‐defined PTT spherulites instead of tremendous stunted spherulites were observed from POM, which means only a small portion of GO powders was acted as nucleation agent. Meanwhile, GO powders had no effect on PTT spherulites growth rate. In addition, the band spacing of PTT spherulites became weaker and wider with increasing GO content. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40332.