bluuebunny/crossref_metadata_2025_split huggingface dataset:
Frontline rituximab, cyclophosphamide, doxorubicin, and prednisone with bortezomib (VR-CAP) or vincristine (R-CHOP) for non-GCB DLBCL
Authors: Offner Fritz , Samoilova Olga , Osmanov Evgenii , Eom Hyeon-Seok , Topp Max S. , Raposo João , Pavlov Viacheslav , Ricci Deborah , Chaturvedi Shalini , Zhu Eugene , van de Velde Helgi , Enny Christopher , Rizo Aleksandra , Ferhanoglu Burhan 
Published: July 2015

Key Points
This trial evaluated frontline VR-CAP and R-CHOP therapy for patients with centrally confirmed non-GCB DLBCL. There was no significant improvement in response rates or long-term outcomes with VR-CAP vs R-CHOP in previously untreated non-GCB DLBCL.
Mice expressing a mutant form of fibrinogen that cannot support fibrin formation exhibit compromised antimicrobial host defense
Authors: Prasad Joni M. , Gorkun Oleg V. , Raghu Harini , Thornton Sherry , Mullins Eric S. , Palumbo Joseph S. , Ko Ya-Ping , Höök Magnus , David Tovo , Coughlin Shaun R. , Degen Jay L. , Flick Matthew J. 
Published: July 2015

Key PointsMutation of the fibrinogen Aα chain in mice to selectively eliminate thrombin cleavage prevents fibrin polymer formation in vivo. Fibrin polymer formation drives antimicrobial function and supports host survival following S aureus peritoneal infection.
Association of genetic loci for migraine susceptibility in the she people of China
Authors: Lin Qi-Fang , Fu Xian-Guo , Yao Long-Teng , Yang Jing , Cao Luo-Yuan , Xin Yong-Tong , Hou Jun-Xia , Ye Lin-Feng , Huang Gen-Bin 
Published: July 2015

Abstract

Background
The purpose of this study was to investigate the association of the genotype and allele frequencies of the polymorphisms rs4379368, rs10504861, rs10915437, rs12134493 and rs13208321 in She people of China with migraine headache susceptibility. The five alleles were previously identified as being associated with migraine in a Western population, but it was not known if this association would hold in a She population. rs4379368 is in the succinic HMG coenzyme A transferase (C7orf10) gene; rs10504861 is near the matrix metallopeptidase 16 (MMP16) gene; rs10915437 is near the adherens junctions associated protein 1 (AJAP1) gene; rs12134493 is upstream of the tetraspanin 2 (TSPAN2) gene; and rs13208321 is within the four and a half LIM domains protein 5 (FHL5) gene.

Methods
This was a case-controlled study conducted in She people of Fujian province in China. Polymerase chain reaction-restriction fragment length polymorphism and direct sequencing were performed. Univariate and multivariate analyses were used to assess the association of the different genotypes of each SNP with migraine.

Results
The rs4379368 T allele was not in Hardy-Weinberg equilibrium and was more common than the C allele in subjects with migraine (58.7 %; P = 0.049), possibly suggesting a selection bias for T allele in this population. In support of this, the CT and TT genotypes were more frequent in the migraine compared with the control groups (54.0 % and 31.7 % vs. 48.0 % and 28.7 %, respectively; P = 0.019). These genotypes were also more common in females with migraines than females without migraines (53.8 % and 30.9 % vs. 46.7 % and 27.6 %; P = 0.026). Univariate and multivariate analyses found the CC genotype of rs4379368 and AA or AG genotype of rs13208321 were associated with a reduced risk of migraine (P values ≤0.039).

Conclusions
Our findings suggest that rs4379368 and rs13208321 are potential genetic markers for migraine in this She population. The findings of this study and others indicate important differences between ethnic populations in regard to genetic markers of migraine susceptibility.
Suzuki type theorems in triangular and non-Archimedean fuzzy metric spaces with application
Authors: Hussain Nawab , Hezarjaribi Masoomeh , Salimi Peyman 
Published: July 2015

AbstractIn this paper, first we introduce certain new classes of Suzuki type contractions in triangular and non-Archimedean fuzzy metric spaces. Further we establish fixed point theorems for such kind of mappings in non-Archimedean and triangular fuzzy metric spaces. We also prove Suzuki type fixed point results in non-Archimedean and triangular ordered fuzzy metric spaces. The results presented here improve and generalize certain recent results from the literature. Two illustrative examples and an application to integral equations are given to support the usability of our results.
Thallium exists in opioid poisoned patients
Authors: Ghaderi Amir , Vahdati-Mashhadian Naser , Oghabian Zohreh , Moradi Valiallah , Afshari Reza , Mehrpour Omid 
Published: July 2015

Abstract

Background
Thallium (Tl) is a toxic heavy metal that exists in nature. Tl poisoning (thallotoxicosis) may occur in opioid addicts. This study was designed to evaluate the frequency and level of urinary Tl in opioid abusers. In addition, clinical findings were evaluated.

Methods
A total of 150 subjects were examined. Cases with a history of at least 3 years of abuse were admitted in the Imam Reza Hospital as the case group; 50 non-opioid abusers from the target population were included as the control group. Twenty-four hour urinary qualitative and quantitative Tl analyses were performed on both groups.

Results
Out of the 150 subjects, 128 (85 %) were negative for qualitative urinary Tl, followed by 5 % (trace), 7 % (1+), 2 % (2+), and 1 % (3+). Mean (standard error (SE), Min–Max) quantitative urinary Tl level was 14 μg/L (3.5 μg/L, 0–346 μg/L). Mean urinary Tl level in the case group was 21 μg/L (5 μg/L, 0–346 μg/L) and that in the controls was 1 μg/L (0.14 μg/L, 0–26 μg/L), which were significantly different (P = 0.001). The most frequent clinical findings were ataxia (86 %), sweating (81 %), and constipation (54 %). In all cases (n = 150), the mean (SE) value for cases with positive qualitative urinary Tl was 26.8 μg/L (0.9 μg/L) and that in the negative cases was 2.3 μg/L (0.2 μg/L), which were significantly different (P = 0.002).

Conclusions
This study showed that long-term opioid abuse may lead to Tl exposure. In opioid abusers with the clinical manifestation of thallotoxicosis, urinary Tl should be determined.
Generation of stable ARE- driven reporter system for monitoring oxidative stress
Authors: Motahari Paria , Sadeghizadeh Majid , Behmanesh Mehrdad , Sabri Shaghayegh , Zolghadr Fatemeh 
Published: July 2015

Abstract

Background
NF-E2-related factor2 (Nrf2)-antioxidant response element (ARE) signaling pathway is the major defensive mechanism against oxidative stress and is up regulated by specific antioxidants and oxidants to comprise the chemoptotective response. Detection of ARE-activating compounds helps to develop new drugs and identify/quantify the tension range of the oxidants.
Important reasons promoting this work are high throughput, rapid and inexpensive experiments relative to the in vitro studies for ARE-Nrf2 pathway monitoring of chemicals and environmental samples.

Methods
In this study hepatoma Huh7 reporter cell line was generated which contains a luciferase gene under the control of an ARE. This is the first example of ARE construct containing one copy of extended consensus response element. The cells were treated with hydroquinone (HQ) and p-benzoquinone (BQ) (oxidative stress inducers) and the antioxidant, curcumin.

Results
The luciferase activity was induced in a concentration-dependent manner in a concentration range of 1–2 μM for BQ and HQ. Curcumin was also validated as an ARE inducer in concentration above 10 μM. In addition, this reporter cell line provides a rapid detection as early as 4 h to respond to the ARE inducers.

Conclusion
It is a powerful tool for the sensitive and selective screening of chemicals, drugs and environmental samples for their antioxidant and oxidant activities.
The chemical-physical knowledge before the restoration: the case of “The Plague in Lucca”, a masterpiece of Lorenzo Viani (1882–1936)
Authors: Grifoni E , Briganti L , Marras L , Orsini S , Colombini M P , Legnaioli S , Lezzerini M , Lorenzetti G , Pagnotta S , Palleschi V 
Published: July 2015

Abstract

Background
“The Plague in Lucca”, a masterpiece of the
contemporary painter Lorenzo Viani, was studied by multi-analytical techniques (Multiband, IR and UV fluorescence imaging, micro-Raman spectroscopy, direct exposure–mass spectrometry, gas chromatography–mass spectrometry and energy dispersive X-ray fluorescence) in view of its restoration at the Gallery of Modern and Contemporary Art (GAMC) of Palazzo delle Muse in Viareggio (Lucca, Italy). The analysis allowed to obtain a better understanding of the artistic technique of the painter and to underline critical conservation aspects.

Results
At first, non-invasive techniques, such as the Multiband Imaging, Infrared Reflectometry, UV Fluorescence and X-ray Fluorescence, have been applied in order to characterize the conservation state of the painting surface and determining the more representative zones of the painting for the taking of micro-samples to be analysed in the laboratory. The destructive chemical analysis of these micro-samples, performed using mass (DEMS and GC/MS) and infrared spectroscopy (micro-Raman), permitted to reveal the nature of the organic and inorganic materials present in the painting.

Conclusions
The use of different physical and chemical diagnostic techniques allowed us to obtain precious information about the palette and the technique used by Lorenzo Viani for the realization of “La Peste a Lucca”. Furthermore, this approach permit to characterize paintings, to understand the nature and origin of materials used by the artist and to develop the appropriate restoration procedure.
Effect of anaesthesia on the perioperative outcomes of pelvi-acetabular fracture surgeries in the apex trauma centre of a developing country–a retrospective analysis
Authors: Yadav Naveen , Ahmad Suma Rabab , Saini Nisha , Gupta Babita , Sawhney Chhavi , Garg Rakesh , Sharma Vijay , Trikha Vivek 
Published: July 2015

Abstract

Background
Regional anaesthesia has been proposed to reduce intraoperative blood loss, duration of hospital stay and in-hospital complications with improved postoperative pain control. General anaesthesia is advantageous for prolonged surgeries. We hypothesized that combined regional and general anaesthesia would offer advantages of both in pelvi-acetabular fracture surgeries.

Methods
We identified 71 patients who underwent open reduction and internal fixation of pelvi-acetabular fractures from May 2012 to 2013 in our trauma centre. We excluded patients with incomplete records (n = 4) and other injuries operated along (n = 8). Hence, 59 patients were divided into three groups: G group (general anaesthesia), R group (regional anaesthesia) and GR group (combined regional and general anaesthesia).
Main outcome measurements studied were intraoperative blood loss, duration of hospital stay, duration of surgery and intraoperative and postoperative complications.

Results
No differences were obtained in between the groups in terms of age, gender, Injury Severity Score, number of comorbidities, or duration from injury to surgery. No significant differences were found between the three groups for intraoperative blood loss, days of hospital stay and duration of surgery. Intraoperative and postoperative complications were also comparable between the groups (p &gt; 0.05).

Conclusions
There is no specific significant advantage of the technique of anaesthesia on the observed perioperative complications in pelvi-acetabular fracture surgeries.
Helical Conformation Stability of Poly[3,5-bis(hydroxymethyl)phenylacetylene]s Depending on the Length of Their Rigid and Linear π-Conjugated Side Groups
Authors: Shi Zhichun , Teraguchi Masahiro , Aoki Toshiki , Kaneko Takashi 
Published: July 2015

Abstract
We synthesized new 3,5-bis(hydroxymethyl)phenylacetylene (HPA) monomers connected with a rigid and linear π-conjugated oligomer. The monomers were successfully polymerized with a rhodium catalyst [Rh(nbd)Cl]2 in the presence of chiral PEA to give the corresponding polymers. Helix-sense-selective polymerization proceeded for DBHPA. CD, UV, and WAXS spectroscopic studies revealed that the intramolecular hydrogen bonds of the polymers contributed to the stabilization of their helical conformation but the stability depended on the length of the rigid and linear π-conjugated side group.
Service Failure Recovery and Prevention: Managing Stockouts in Distribution Channels
Authors: Dong Yan , Xu Kefeng , Cui Tony Haitao , Yao Yuliang 
Published: July 2015

In managing service failures such as stockouts, most research has emphasized preventive mechanisms, whereas stockout recovery mechanisms have been largely ignored. We propose and examine a failure-recovery mechanism (i.e., contractual stockout recovery) in the presence of demand uncertainty and compare it with failure-prevention mechanisms in a dyadic distribution channel. We find that stockout recovery mechanisms can improve channel profitability under certain conditions. More importantly, we find that stockout recovery may outperform stockout prevention mechanisms such as return policy and vendor managed inventory in improving manufacturer and channel profitability. This is because stockout recovery reduces channel-wide stockout risks and allows benefits from the reduced risks to be shared between the manufacturer and the retailer, helping alleviate double marginalization. Although return policy also reduces stockout risks, it does so by increasing inventory risks in the channel without reducing channel exposure to demand uncertainty. Thus, our research suggests that stockout recovery can be an effective alternative in managing stockouts to those common methods of stockout prevention mechanisms.
The raw deal: clarifying the nutritional and public health issues regarding raw meat-based diets
Authors: Lumbis Rachel , Chan Daniel L 
Published: July 2015

In recent years, there has been growing interest in the feeding of unconventional diets such as raw, vegetarian and home prepared diets to companion animals. BARF diets, often referred to as ‘Biologically Appropriate Raw Food’ or ‘Bones And Raw Food,’ were popularised by Billinghurst in 1993. Such diets typically consist of 60–80% raw meaty bones and 20–40% a wide variety of foods including fruit and vegetables, offal, meat, eggs, or dairy foods.Prior to domestication, the diet of dogs and cats consisted largely of raw food. Once cohabiting with humans, raw food remained the staple diet for cats whereas dogs survived on by-products of human consumption, i.e. table scraps. The nutritional inadequacy of these diets is cited as being responsible for the shortened life span and nutritionally-related digestive, musculoskeletal problems encountered at that time. Yet, current justification for the feeding of this diet stems from the belief that these species are healthier when fed as if still in the wild.This article explores the nutritional adequacy and food safety issues related to feeding raw meat-based diets to companion animals and considers approaches for communicating with pet owners about the concerns regarding these unconventional diets.
Before and after Study of Pharmacists' and Students' Knowledge of Two Novel Antidotes: High-Dose Insulin Euglycemia and Intravenous Fatty Acid Emulsion 20%
Authors: Jellinek-Cohen Samantha P. , Tolento Amanda , Howland Mary Ann 
Published: July 2015

Purpose To assess pharmacists' and students' knowledge of high-dose insulin euglycemia (HIE) and intravenous fatty acid emulsion 20% (IFE) and to see whether it improved after an educational intervention. Methods A survey to assess the knowledge about the use of HIE and IFE as antidotes was e-mailed to practicing pharmacists, pharmacy residents, and students prior to and following an educational intervention. Fact sheets on the antidotes were developed in conjunction with the New York City Poison Control Center and were used as the educational intervention in this study. The impact of exposure to the intervention was measured by comparing the number of correct responses per question on the pre- and posttests and the mean pre- and posttest scores using chi-square and t tests, respectively. Results Most respondents felt either not at all or only somewhat comfortable with managing a toxicologic emergency. There was a statistically significant difference in mean scores on the pretest and posttest (2.9 vs 5.45; P = .001) and for the number of participants giving correct responses for each question before and after education: 52.4% of respondents answered “I don't know” to the questions prior to education versus 21.2% after education ( P < .001). Fewer respondents felt not at all comfortable managing a toxicologic emergency after the educational intervention (42.4 vs 50.3%; P < .001). Conclusion Pharmacists and students reported little comfort in managing toxicological emergencies in general and have limited baseline knowledge about these agents. Educational interventions can significantly improve knowledge. Prior familiarity with these newer antidotes should reduce delays in their administration in an emergency.
Implementation of Advanced Inventory Management Functionality in Automated Dispensing Cabinets
Authors: Findlay Russell , Webb Aaron , Lund Jim 
Published: July 2015

Background Automated dispensing cabinets (ADCs) are an integral component of distribution models in pharmacy departments across the country. There are significant challenges to optimizing ADC inventory management while minimizing use of labor and capital resources. The role of enhanced inventory control functionality is not fully defined. Objective The aim of this project is to improve ADC inventory management by leveraging dynamic inventory standards and a low inventory alert platform. Methods Two interventional groups and 1 historical control were included in the study. Each intervention group consisted of 6 ADCs that tested enhanced inventory management functionality. Interventions included dynamic inventory standards and a low inventory alert messaging system. Following separate implementation of each platform, dynamic inventory and low inventory alert systems were applied concurrently to all 12 ADCs. Outcome measures included number and duration of daily stockouts, ADC inventory turns, and number of phone calls related to stockouts received by pharmacy staff. Results Low inventory alerts reduced both the number and duration of stockouts. Dynamic inventory standards reduced the number of daily stockouts without changing the inventory turns and duration of stockouts. No change was observed in number of calls related to stockouts made to pharmacy staff. Conclusions Low inventory alerts and dynamic inventory standards are feasible mechanisms to help optimize ADC inventory management while minimizing labor and capital resources.
Stability of Reconstituted Telavancin Drug Product in Frozen Intravenous Bags
Authors: Gu Zhengtian , Wong Anissa , Raquinio Elvira , Nguyen Alice 
Published: July 2015

Background and Objective Intravenous (IV) infusions of telavancin for injection are generally administered in-hospital, but in some circumstances they may be administered in an outpatient environment. In that setting, antibiotics may be premixed and frozen. This study determined the chemical stability of nonpreserved telavancin in various commonly used reconstitution diluents stored in IV bags (polyvinyl chloride [PVC] and PVC-free) at −20°C (-4°F) without light. Methods Telavancin (750 mg/vial) was reconstituted with 5% dextrose injection USP (D5W) or 0.9% sodium chloride injection USP (NS) to obtain drug solutions at approximately 15 mg/mL. Infusion solutions of telavancin at diluted concentrations of 0.6 mg/mL and 8.0 mg/mL covering the range utilized in clinical practice were prepared in both PVC and PVC-free IV bags using D5W or NS solutions. The infusion solutions were stored under frozen conditions (-20°C ± 5°C [-4°F ± 41°F]) and the chemical stability was evaluated for up to 32 days. Telavancin concentration, purity, and degradant levels were determined using a stability-indicating high-performance liquid chromatography (HPLC) method. Results Telavancin IV infusion solutions in D5W or NS at 0.6 mg/mL and 8 mg/mL and stored at −20°C (-4°F) met the chemical stability criteria when tested on days 0, 7, 14, and 32. The assayed telavancin concentration at each time point was within 97% to 103% of the initial mean assay value. The total degradants quantified by the HPLC stability-indicating method did not show any significant change over the 32-day study period. Conclusion Telavancin IV infusion solutions (in D5W or NS) in both PVC and PVC-free IV bags were stable for at least 32 days when stored at −20°C (-4°F) without light. These results provide prolonged frozen stability data further to that previously established for 7 days under refrigerated conditions (2°C-8°C [36°F −46°F]), and for 12 hours at room temperature when diluted into IV bags containing D5W, NS, or lactated Ringer's solution.
Ventricular Tachycardia Precipitated by the Use of the Diet Supplement Hydroxycut Gummies
Authors: Hammond Drayton A. , Thano Estela , Bohnenberger Kristin A. , McAllister Matthew W. , Wannenburg Thomas , Hsu Steve , Gurley Bill J. , Kim Robert 
Published: July 2015

Background Dietary supplements have a long history of causing adverse effects. Ventricular arrhythmias have not been described with Hydroxy cut Gummies. Objective To report a case of ventricular arrhythmia after prolonged use of a popular dietary supplement, Hydroxy cut Gummies. Case Report An 18-year-old female with no significant past medical history presented with life-threatening ventricular arrhythmia following about 10 days of use of Hydroxycut Gummies, a legal dietary supplement previously unreported to cause this complication. The patient received external cardioversion due to progressive decline in mental status and persistent hypotension and was initiated on intravenous procainamide at an outside hospital. Left ventricular ejection fraction was 45% to 50%, and cardiac MRI showed no definite finding of infarct, myocarditis, or fibrosis. Beta-blocker therapy was initiated, and there was a progressive reduction in ventricular arrhythmia burden with an improvement of symptoms over the next few days. Two and a half months after the initial hospitalization, follow-up Holter monitor revealed occasional accelerated idioventricular rhythm events and a significant reduction in, but still occasional, long monomorphic ventricular tachycardia events. None of the ingredients listed in this product have been associated with cardiac dysrhythmias in the literature. One phytochemical potentially in the product is alpha-quinidine, which could be the cause of the adverse event. However, there was no other identifiable etiology for the ventricular tachycardia, which resolved after the discontinuation of supplement and the addition of beta-blocker therapy. Conclusion Hydroxycut Gummies should be considered a probable cause of this patient's arrhythmia given the lack of another etiology and a Naranjo Scale score of 6.