bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shared Genetic Liability across Systems of Psychiatric and Physical Illness
Authors: Lawrence Jeremy M. , Foote Isabelle F. , Breunig Sophie , Schaffer Lukas S. , Mallard Travis T. , Grotzinger Andrew D. 
Published: August 2024

AbstractEpidemiological literature has shown that there are extensive comorbidity patterns between psychiatric and physical illness. However, our understanding of the multivariate systems of relationships underlying these patterns is poorly understood. Using Genomic SEM and Genomic E-SEM, an extension for genomic exploratory factor analysis that we introduce and validate, we evaluate the extent to which latent genomic factors from eight domains, encompassing 76 physical outcomes across 1.9 million cases, evince genetic overlap with previously identified psychiatric factors. We find that internalizing, neurodevelopmental, and substance use factors are broadly associated with increased genetic risk sharing across all physical illness domains. Conversely, we find that a compulsive factor is protective against circulatory and metabolic illness, whereas genetic risk sharing between physical illness factors and psychotic/thought disorders was limited. Our results reveal pervasive risk sharing between specific groups of psychiatric and physical conditions and call into question the bifurcation of psychiatric and physical conditions.
Associations between genetic HPV 16 diversity and cervical cancer prognosis
Authors: Patury Patrícia , Russomano Fábio B. , Martins Luiz F.L. , Moreira Miguel Angelo Martins , Carvalho Raquel B.M. , Kappaun Nádia R. C. , de Almeida Liz Maria 
Published: August 2024

AbstractIntroductionCervical cancer (CC) arises as a result of chronic and persistent female genitalia infection by different oncogenic human papillomaviruses (HPV). The incidence of this disease is still high in developing countries such as Brazil, where the diagnosis is often made in advanced stages. HPV 16 is the most common type of CC worldwide. Studies concerning the association of different HPV 16 lineages with overall and disease-free CC survival rates can contribute to further understanding the behavior of different HPV 16 lineages concerning the prognosis of CC cases.ObjectiveAssess the CC prognosis of patients treated in a Brazilian institution with regard to HPV16 strains.MethodsData were obtained from a prospective cohort of 334 CC patients recruited between July 2011 and March 2014 and treated at the Brazilian National Cancer Institute (INCA), in Rio de Janeiro, Brazil. HPV 16 lineages were identified in tumor tissue samples. Genetic HPV 16 diversity comprised 218 cases of lineage A, 10 of lineage B, 10 of lineage C and 96 of lineage D. In addition to HPV 16 lineages, age, histopathological type, staging, and treatment completion were evaluated regarding CC prognosis.ResultsMedian patient age was 48 years old. The most common histopathological type was squamous cell carcinoma (82.3%), followed by adenocarcinoma. Locally advanced disease staging was the most frequently detected, represented by similar stage II and III percentages (36.2% and 37.7%), followed by initial stage I (19.2%) and stage IV presenting distant disease (6.9%). Only 187 patients completed CC treatment. Age, histological type, staging, and treatment completion were associated with a higher risk of death, which was not observed for the HPV 16 lineage variable. With regard to age, each one year of life increase led to about a 1% increase in risk of death. Other histopathological types (poorly differentiated carcinoma, adenosquamous, neuroendocrine and sarcoma) were associated with a higher risk of death compared to adenocarcinoma. Squamous cell carcinoma also represented a higher risk of death compared to adenocarcinoma, albeit non-statistically significant. Patients diagnosed in advanced stages exhibited a higher risk of death, and those who did not complete treatment exhibited an over 2-fold increased risk of death.ConclusionThis study found no associations between HPV 16 lineages A, B, C and D and CC prognosis.
A new clade of pararetroviruses distantly related to hepadnaviruses and nackednaviruses
Authors: Buigues Jaime , Viñals Adrià , Martínez-Recio Raquel , Monrós Juan S. , Cuevas José M. , Sanjuán Rafael 
Published: August 2024

AbstractGroup VII of the Baltimore classification comprises reverse-transcribing, non-integrated DNA viruses, also known as pararetroviruses. These include the hepadnaviruses, a family of small enveloped DNA viruses that infect vertebrates, but also a sister family of non-enveloped fish viruses, the nackednaviruses. Here we describe the complete sequence of a new pararetrovirus found in the feces of an insectivorous bat. This virus encodes a core protein and a reverse transcriptase but no envelope protein. A database search identified a viral sequence from a permafrost sample as its closest relative. The two viruses form a cluster that occupies a basal phylogenetic position relative to hepadnaviruses and nackednaviruses, with an estimated divergence time of 500 million years. These findings may lead to the definition of a new viral family and support the hypothesis that ancestral animal pararetroviruses were non-enveloped.
Microcystins are critical for the toxicMicrocystisto survive long-term nitrogen starvation
Authors: Lian Xiao-Ya , Qiu Guo-Wei , Zheng Wen-Can , Shang Jin-Long , Xu Hai-Feng , Dai Guo-Zheng , Gan Nan-Qin , Zhang Zhong-Chun , Qiu Bao-Sheng 
Published: August 2024

ABSTRACTToxic cyanobacterial blooms have expanded and intensified on a global scale, but the physiological role of microcystins during bloom development is not fully resolved. Here, we show that microcystin production can increase the survival and resuscitation rate ofMicrocystisafter long-term nitrogen starvation. Our results showed that microcystin production could enable toxicMicrocystisto accumulate more carbon reserves under nitrogen limitation, which is critical to support the survival of cells under stressful conditions. Further analysis showed that genes involved in microcystin synthesis were significantly upregulated at the initial phase of recovery, which could help toxicMicrocystisto strengthen glycogen catabolism and fuel recovery. The close genetic traits betweenMicrocystisstrains suggest the strategies observed here might be highly conserved. Our findings imply how toxicMicrocystisestablish a competitive advantage over non-toxic species and provide new insight into the seasonal dynamic of theMicrocystispopulation in natural environment.IMPORTANCEMicrocystins are the most abundant cyanotoxins released during harmful algal blooms. While the factors controlling microcystin production have been widely studied, the function of these toxic secondary metabolites under changing environments remains poorly understood. Here we proved that microcystins are critical to toxicMicrocystisto maintaining carbon metabolism under long-term nitrogen starvation and subsequent recovery. Compared to the non-toxic strains, microcystin-producingMicrocystisexhibit a higher viability and resuscitation rate after prolonged nitrogen starvation, which is consistent with the dominance of these species at the early stage of cyanobacterial blooms. Our findings shed light on the genetic traits that drive population succession during bloom development, which is important for the modeling and prediction of harmful cyanobacterial blooms.
Transcriptomic Meta-analysis Identifies Long Non-Coding RNAs Mediating Zika’s Oncolytic Impact in Glioblastoma Multiforme
Authors: Kousa Youssef A. , Singh Shriya , Horvath Allison , Tomasso Federica , Nazarian Javad , Henderson Lisa , Mansour Tamer A. 
Published: August 2024

ABSTRACTGlioblastoma multiforme (GBM) is an aggressive and lethal form of brain cancer with few effective treatments. In this context, Zika virus has emerged as a promising therapeutic agent due to its ability to selectively infect and kill GBM cells. To elucidate these mechanisms and expand the landscape of oncolytic virotherapy, we pursued a transcriptomic meta-analysis comparing the molecular signatures of Zika infection in GBM and neuroblastoma (NBM). Over-representation analysis of dysregulated coding genes showed significant enrichment of tumor necrosis factor (TNF), NF-κB, and p53 signaling pathways. A refined list of long non-coding RNAs consistently dysregulated in Zika-infected GBMs was also developed. Functional review of these candidates revealed their potential regulatory role in Zika-mediated oncolysis. We performed validation of the less-researched targets in adult and pediatric GBM cell lines and found significant differential regulation, as predicted. Altogether, our results provide novel insights into the molecular mechanisms underlying the effect of Zika on GBM. We highlight potential therapeutic targets that could be further interrogated to improve the efficacy of tumor cell death and the utility of Zika as an adjuvant virotherapy for GBM and other related cancers.
Differential regulation of BAX and BAK apoptotic activity revealed by a novel small molecule
Authors: Li Kaiming , Yap Yu Q. , Moujalled Donia M. , Sumardy Fransisca , Khakham Yelena , Georgiou Angela , Jahja Michelle , Lew Thomas E. , De Silva Melanie , Luo Meng-Xiao , Gong Jia-nan , Roberts Andrew W. , Yuan Zheng , Birkinshaw Richard W. , Czabotar Peter E. , Lowes Kym , Huang David C. S. , Kile Benjamin T. , Wei Andrew H. , Dewson Grant , van Delft Mark F. , Lessene Guillaume 
Published: August 2024

AbstractDefective apoptosis mediated by BAK or BAX underlies various human pathologies including autoimmune and degenerative conditions. The mitochondrial channel protein VDAC2 interacts with BAK and BAX through a common interface to either inhibit BAK or to facilitate BAX apoptotic activity. Using a newly developed small molecule (WEHI-3773) that inhibits the interaction between VDAC2 and BAK or BAX, we reveal contrasting effects on BAX and BAK apoptotic activity. WEHI-3773 inhibits apoptosis mediated by BAX by blocking VDAC2-mediated BAX recruitment to mitochondria. Conversely, WEHI-3773 primes BAK for apoptosis by impairing its inhibitory sequestration by VDAC2 on the mitochondrial membrane. In cells expressing both BAX and BAK, repressing their association with VDAC2 promotes apoptosis, because once BAK is activated, it further activates BAX through a feed-forward mechanism. In some leukemias, mutation or loss of BAX is a key driver of resistance to the BH3-mimetic anti-cancer drug venetoclax. Strikingly, promoting BAK-mediated killing by small molecule dissociation of the VDAC2 interaction can overcome this resistance in different leukemia models. These data reveal a hitherto unappreciated level of coordination of BAX and BAK apoptotic activity through their interaction with VDAC2 that may be targeted therapeutically.
Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1
Authors: Wolf van der Meer Joyce , Larue Axelle , van der Knaap Jan A. , Chalkley Gillian E. , Sijm Ayestha , Beikmohammadi Leila , Kozhevnikova Elena N. , van der Vaart Aniek , Tilly Ben C. , Bezstarosti Karel , Dekkers Dick H. W. , Doff Wouter A. S. , van de Wetering-Tieleman P. Jantine , Lanko Kristina , Barakat Tahsin Stefan , Allertz Tim , van Haren Jeffrey , Demmers Jeroen A. A. , Atlasi Yaser , Verrijzer C. Peter 
Published: August 2024

ABSTRACTPathogenic variants in the ubiquitin-specific protease 7 (USP7) gene cause a neurodevelopmental disorder called Hao-Fountain syndrome. However, which of USP7’s pleiotropic functions are relevant for neurodevelopment remains unclear. Here, we present a combination of quantitative proteomics, transcriptomics and epigenomics to define the USP7 regulatory circuitry during neuronal differentiation. USP7 activity is required for the transcriptional programs that direct both differentiation of embryonic stem cells into neural stem cells, and the neuronal differentiation of SH-SY5Y neuroblastoma cells. USP7 controls the dosage of the Polycomb H2AK119ub1 ubiquitin ligase complexes ncPRC1.1 and ncPRC1.6. Loss-of-function experiments revealed that BCOR-ncPRC1.1, but not ncPRC1.6, is a key effector of USP7 during neuronal differentiation. Indeed, BCOR-ncPRC1.1 mediates a major portion of USP7-dependent gene regulation during this process. Besides providing a detailed map of the USP7 regulome during neurodifferentiation, our results suggest that USP7 and ncPRC1.1-associated neurodevelopmental disorders involve dysregulation of a shared epigenetic network.
Compensating slice emittance growth in high brightness photoinjectors using sacrificial charge
Authors: Li W. H. , Bartnik A. C. , Fukasawa A. , Kaemingk M. , Lawler G. , Majernik N. , Rosenzweig J. B. , Maxson J. M. 
Published: August 2024

Achieving maximum electron beam brightness in photoinjectors requires detailed control of the 3D bunch shape and precise tuning of the beam focusing. Even in state-of-the-art designs, slice emittance growth due to nonlinear space charge forces and partial nonlaminarity often remains non-negligible. In this work, we introduce a new means to linearize the transverse slice phase space: a sacrificial portion of the bunch’s own charge distribution, formed into a wavebroken shock front by highly nonlinear space charge forces within the gun, whose downstream purpose is to dynamically linearize the desired bunch core. We show that linearization of an appropriately prepared bunch can be achieved via strongly nonlaminar focusing of the sacrificial shock front, while the inner core focuses laminarly. This leads to a natural spatial separation of the two distributions: a dense core surrounded by a diffuse halo of sacrificial charge that can be collimated. Multiobjective genetic algorithm optimizations of the ultracompact x-ray free electron laser injector employ this concept, and we interpret it with an analytic model that agrees well with the simulations. In simulation, we demonstrate a final bunch charge of 100 pC, peak current ∼30 A, and a sacrificial charge of 150 pC (250 pC total emitted from cathode) with normalized emittance growth of <20  nm rad due to space charge. This implies a maximum achievable brightness approximately an order of magnitude greater than existing free electron laser injector designs.

Published by the American Physical Society
2024
Rotational holographic transport from Kerr-Newman-AdS black hole
Authors: Meert Pedro , Nastase Horatiu 
Published: August 2024

We consider rotational holographic transport in strongly coupled 2+1-dimensional systems, from the point of view of 3+1-dimensional gravity. We consider the moment of inertia I as a kind of transport coefficient, identified with the moment of inertia of a charged rotating black hole in AdS4 background. In the low-temperature region, we find the behavior of the density I/A with temperature T and angular velocity Ω and find a quadratic behavior for ∂(I/A)/∂Ω with T, in the presence of some charge Q.

Published by the American Physical Society
2024
Random telegraph processes with nonlocal memory
Authors: Apostolov S. S. , Usatenko O. V. , Yampol'skii V. A. , Melnyk S. S. , Grigolini P. , Krokhin A. 
Published: August 2024

We study two-state (dichotomous, telegraph) random ergodic continuous-time processes with dynamics depending on their past. We take into account the history of the process in an explicit form by introducing integral nonlocal memory term into conditional probability function. We start from an expression for the conditional transition probability function describing additive multistep binary random chain and show that the telegraph processes can be considered as continuous-time interpolations of discrete-time dichotomous random sequences. An equation involving the memory function and the two-point correlation function of the telegraph process is analytically obtained. This integral equation defines the correlation properties of the processes with given memory functions. It also serves as a tool for solving the inverse problem, namely for generation of a telegraph process with a prescribed pair correlation function. We obtain analytically the correlation functions of the telegraph processes with two exactly solvable examples of memory functions and support these results by numerical simulations of the corresponding telegraph processes.

Published by the American Physical Society
2024
The corrosion analysis of X80 pipeline steel welded joint using wire beam electrode and numerical simulation methods
Authors: Dou Xiaohui , Li Yadong , Zhang Xinwei , Wang Shengnan , Cheng Yang , Yao Wanpeng , Zhang Dalei , Li Yan 
Published: August 2024

Purpose
The purpose of this study is to characterize the galvanic corrosion behavior of a simulated X80 pipeline steel welded joint (PSWJ) reconstructed by the wire beam electrode (WBE) and numerical simulation methods.

Design/methodology/approach
The galvanic corrosion of an X80 PSWJ was studied using WBE and numerical simulation methods. The microstructures of the coarse-grained heat affected zone, fine-grained heat affected zone and intercritical heat affected zone were simulated in X80 pipeline steel via Gleeble thermomechanical simulation processing.

Findings
Comparing the corrosion current density of coupled and isolated weld metal (WM), base metal (BM) and heat-affected zone (HAZ), the coupled WM exhibited a higher corrosion current density than isolated WM; the coupled BM and HAZ exhibited lower corrosion current densities than isolated BM and HAZ. The results exhibited that the maximum anodic galvanic current fitted the Gumbel distribution. Moreover, the numerical simulation results agreed well with the experimental data.

Originality/value
This study provides insight into corrosion evaluation of heterogeneous welded joints by a combination of experiment and simulation. The method of reconstruction of the welded joint has been proven to be a feasible approach for studying the corrosion behavior of the X80 PSWJ with high spatial resolution.
The power control and efficiency optimization strategy of dynamic wireless charging system for multiple electric vehicles
Authors: Zhang Ming , Zhang Hantao , Tao WeiYe , Yang Yan , Sang Yingjun 
Published: August 2024

Purpose
This study aims to solve the problem that both the speed and the required driving power of electric vehicles (EVs) will change during the dynamic wireless charging (DWC) process, making it difficult to charge EVs with a constant power considering the overall efficiency of DWC system, the numbers of EVs and the power supply capacity. Therefore, this paper proposes the power control and efficiency optimization strategies for multiple EVs.

Design/methodology/approach
The wireless power charging system for multiple loads with a structure of double-sided LCC compensation topology is established. The expressions of optimal transmission efficiency and optimal equivalent impedance are derived. Taking the Tesla Model 3 as an example, a method to determine the number of EVs allowed by one transmitter coil and the overall charging power is proposed considering EV speed, power supply capacity, safe braking distance and overall efficiency. Then, the power control strategy, which can adapt to the changes of EV speed and the efficiency optimization strategy under different numbers of EVs are proposed.

Findings
In this paper, a method to determine the numbers of EVs allowed by one transmitter coil and the overall charging power is proposed considering EVs speed, power supply capacity, safe braking distance and overall efficiency. The accuracy of the charging power is good enough and the overall efficiency reaches a maximum of 91.79% when the load resistance changes from 5Ω to 20Ω.

Originality/value
In this paper, the power control and efficiency optimization strategy of DWC system for multiple EVs are proposed. Specifically, a method of designing the number of EVs and charging power allowed by one transmitter coil considering the factors of EV speed, power supply capacity, safe braking distance and overall efficiency is designed. The overall efficiency of the experiment reaches a maximum of 91.79% after adopting the optimization strategy.
The measurement of fraud perception of investors and the mediating effect of risk aversion: the case of crypto assets
Authors: Özçelik Musa , Kurt Ganite 
Published: August 2024

Purpose
This study aims to gain a new perspective on auditing by measuring investors’ fraud perception and to reveal the necessity of increasing individuals’ fraud perception by determining the effect of fraud perception on the intention to invest in crypto assets from the investor’s perspective.

Design/methodology/approach
As part of this quantitative research, a survey was conducted on individuals residing in Türkiye and aged 18 years and above through a convenience sampling method. A total of 446 participants were included in the study. The data collected was analyzed using the partial least squares-variance based structural equation modeling (PLS-SEM) method using the SmartPLS program.

Findings
Fraud perception causes individuals to be more risk-averse and reduces their intention to invest in crypto assets. At the same time, it has been observed that risk-averse individuals have lower intention to invest in crypto assets. According to the results of the mediating effect analysis, risk aversion behavior partially mediates between the fraud perception and the intention to invest in crypto assets. Among the emotions, only fear increases risk aversion behavior. Among the personality traits, extroversion and openness to experience personality traits reduce risk aversion behavior, whereas neuroticism personality traits increase the intention to invest in crypto assets.

Originality/value
In an environment where traditional auditing activities are insufficient, increasing investors’ perceptions of fraud can reduce fraud-related losses. In this context, to the best of the authors’ knowledge, the present study might be among the first to investigate the impact of individuals’ perceptions of fraud on their investment intentions in crypto assets.
Adaptive coordination strategies in humanitarian action: lessons from the COVID-19 pandemic
Authors: Tosi Laetitia , Marty Justine 
Published: August 2024

Purpose
This study aims to investigate the optimization of coordination mechanisms in humanitarian action and focuses on the challenges posed by the COVID-19 pandemic.

Design/methodology/approach
Conducted as a case study in collaboration with an international humanitarian organization, this research examines the components and associated coordination mechanisms of humanitarian action phases.

Findings
The analysis reveals the complexities of managing humanitarian crises, emphasizing the need for adaptive coordination strategies. Four key crisis response coordination mechanisms are explored – structural configuration, outcome standardization, process standardization and mutual adjustment. The study particularly assesses the emergency-development phase.

Research limitations/implications
This study is limited to a single humanitarian organization and the COVID-19 context. Future research could explore additional case studies and broader contexts to enhance understanding of coordination mechanisms in humanitarian crises.

Practical implications
This research has practical implications for humanitarian organizations, policymakers and practitioners involved in crisis response. Enhancing coordination mechanisms and strategies can improve the efficacy of response efforts and facilitate navigation of the complexities of humanitarian crises.

Social implications
Effective coordination is crucial in mitigating the impact of humanitarian crises and promoting social resilience. By optimizing coordination mechanisms, this research contributes to building more adaptive societies in the face of global challenges.

Originality/value
This study innovatively applies the activities-resources-actors (ARA) model to the humanitarian context and concentrates on the response to COVID-19 of one international humanitarian organization. By adapting the ARA model to a real-world scenario, this research provides insights into optimizing coordination mechanisms in crisis management.