bluuebunny/crossref_metadata_2025_split huggingface dataset:
The prevalence and anatomical characteristics of the accessory head of the flexor pollicis longus muscle: a meta-analysis
Authors: Roy Joyeeta , Henry Brandon M. , Pękala Przemysław A. , Vikse Jens , Ramakrishnan Piravin Kumar , Walocha Jerzy A. , Tomaszewski Krzysztof A. 
Published: October 2015

Background and Objectives.The accessory head of the flexor pollicis longus muscle (AHFPL), also known as the Gantzer’s muscle, was first described in 1813. The prevalence rates of an AHFPL significantly vary between studies, and no consensus has been reached on the numerous variations reported in its origin, innervation, and relationships to the Anterior Interosseous Nerve (AIN) and the Median Nerve (MN). The aim of our study was to determine the true prevalence of AHFPL and to study its associated anatomical characteristics.Methods.A search of the major electronic databases PubMed, EMBASE, Scopus, ScienceDirect, and Web of Science was performed to identify all articles reporting data on the prevalence of AHPFL in the population. No date or language restriction was set. Additionally, an extensive search of the references of all relevant articles was performed. Data on the prevalence of the AHFPL in upper limbs and its anatomical characteristics and relationships including origin, insertion, innervation, and position was extracted and pooled into a meta-analysis using MetaXL version 2.0.Results.A total of 24 cadaveric studies (n= 2,358 upper limb) were included in the meta-analysis. The pooled prevalence of an AHFPL was 44.2% (95% CI [0.347–0.540]). An AHFPL was found more commonly in men than in women (41.1% vs. 24.1%), and was slightly more prevalent on the right side than on the left side (52.8% vs. 45.2%). The most common origin of the AHFPL was from the medial epicondyle of the humerus with a pooled prevalence of 43.6% (95% CI [0.166–0.521]). In most cases, the AHFPL inserted into the flexor pollicis longus muscle (94.6%, 95% CI [0.731–1.0]) and was innervated by the AIN (97.3%, 95% CI [0.924–0.993]).Conclusion.The AHFPL should be considered as more a part of normal anatomy than an anatomical variant. The variability in its anatomical characteristics, and its potential to cause compression of the AIN and MN, must be taken into account by physicians to avoid iatrogenic injury during decompression procedures and to aid in the diagnosis and treatment of Anterior Interosseous Nerve Syndrome.
Measuring the well-being of health care professionals in the Punjab: a psychometric evaluation of the Warwick–Edinburgh Mental Well-being Scale in a Pakistani population
Authors: Waqas Ahmed , Ahmad Waqas , Haddad Mark , Taggart Frances M. , Muhammad Zerwah , Bukhari Muhammad Hamza , Sami Shahzad Ahmed , Batool Sayyeda Mehak , Najeeb Fiza , Hanif Ayesha , Rizvi Zehra Ali , Ejaz Sumbul 
Published: October 2015

Background.There is growing awareness of the public health importance of mental well-being both in the general population and in specific groups. The well-being of health professionals is likely to influence the quality of the care they deliver. This study was carried out to examine the well-being of Pakistani healthcare professionals, and to evaluate the psychometric performance of the Warwick–Edinburgh Mental Well-being Scale (WEMWBS) in this population.Methods.A cross-sectional survey was carried out from June, 2013 to December, 2014 among 1,271 Pakistani health care providers (HCPs) working in seven different cities in Punjab province, Pakistan, to examine the acceptability, internal consistency, test-retest reliability and content and construct validity of the English version of the WEMWBS in a Pakistani population sample. All data were analyzed in SPSS v. 21.Results.Our analysis demonstrated unidimensional construct validity, high internal consistency (0.89) and test-retest reliability, good validity and easy readability of WEMWBS in our sample of Pakistani HCPs. The mean WEMWBS score was 48.1 (SD 9.4), which is lower than in the general population in other countries. Male HCPs scored significantly higher on the WEMWBS than their female counterparts (P< 0.05), and older respondents had higher scores.Conclusion.The WEMWBS appears acceptable for use in Pakistani HCPs, and findings from this study verify its validity and internal consistency for this population sample. Our respondents had lower well-being scores than those reported in general population surveys in the UK.
Surgeon and Care Team Network Measures and Timely Breast Cancer Treatment
Authors: Ash Ramsey , Scodari Bruno T. , Schaefer Andrew P. , Cornelius Sarah L. , Brooks Gabriel A. , O’Malley A. James , Onega Tracy , Verhoeven Dana C. , Moen Erika L. 
Published: August 2024

ImportanceCancer treatment delay is a recognized marker of worse outcomes. Timely treatment may be associated with physician patient-sharing network characteristics, yet this remains understudied.ObjectiveTo examine the associations of surgeon and care team patient-sharing network measures with breast cancer treatment delay.Design, Setting, and ParticipantsThis cross-sectional study of Medicare claims in a US population-based setting was conducted from 2017 to 2020. Eligible participants included patients with breast cancer who received surgery and the subset who went on to receive adjuvant therapy. Patient-sharing networks were constructed for treating physicians. Data were analyzed from September 2023 to February 2024.ExposuresSurgeon linchpin score (a measure of local uniqueness or scarcity) and care density (a measure of physician team familiarity) were assessed. Surgeons were considered linchpins if their linchpin score was in the top 15%. The care density of a patient’s physician team was calculated on preoperative teams for surgically-treated patients and postoperative teams for adjuvant therapy-receiving patients.Main Outcomes and MeasuresThe primary outcomes were surgical and adjuvant delay, which were defined as greater than 60 days between biopsy and surgery and greater than 60 days between surgery and adjuvant therapy, respectively.ResultsThe study cohort included 56 433 patients (18 004 aged 70-74 years [31.9%]) who were mostly from urban areas (44 931 patients [79.6%]). Among these patients, 8009 (14.2%) experienced surgical delay. Linchpin surgeon status (locally unique surgeon) was not statistically associated with surgical delay; however, patients with high preoperative care density (ie, high team familiarity) had lower odds of surgical delay compared with those with low preoperative care density (odds ratio [OR], 0.58; 95% CI, 0.53-0.63). Of the 29 458 patients who received adjuvant therapy after surgery, 5700 (19.3%) experienced adjuvant delay. Patients with a linchpin surgeon had greater odds of adjuvant delay compared with those with a nonlinchpin surgeon (OR, 1.30; 95% CI, 1.13-1.49). Compared with those with low postoperative care density, there were lower odds of adjuvant delay for patients with high postoperative care density (OR, 0.77; 95% CI, 0.69-0.87) and medium postoperative care density (OR, 0.85; 95% CI, 0.77-0.94).Conclusions and RelevanceIn this cross-sectional study of Medicare claims, network measures capturing physician scarcity and team familiarity were associated with timely treatment. These results may help guide system-level interventions to reduce cancer treatment delays.
Collaboration and term usage dynamics in agricultural buffer strip research: Research weaving
Authors: Young Sarah , Lagisz Malgorzata , Callaghan Max W. , Nakagawa Shinichi , Haddaway Neal R. 
Published: August 2024

Abstract

Systematic maps are used to comprehensively gather and describe the literature on a topic, which is often defined by policy and practice relevance and stakeholder input, identifying trends and gaps in research. Bibliometric methods elucidate the connections between publications, for example, providing information about collaboration in research communities. Research weaving combines these approaches to produce a comprehensive view of research activity on a well‐defined research area.

In this paper, we conduct and describe a bibliometric analysis on a previously published systematic map on the functional roles of buffer strips in agricultural fields. Among other findings, the original systematic map found a paucity of studies addressing multiple functional roles and a huge variation in terminology related to buffer strips. We used research weaving to deepen our understanding of these findings and shed light on collaboration within and among the research communities contributing knowledge to this field.

Of the 1019 papers originally included in the systematic map, 930 were identified in Lens.org and used for subsequent analyses. Co‐authorship and bibliographic coupling networks identified distinct research communities, defined by geography, subdiscipline and characteristic usage of buffer strip terminology. Topic modelling provided further information about these subcommunities and aligned with manually extracted information about the studies' focus on functional roles, indicating potential utility for screening of records in large systematic maps.

Practical Implication: We demonstrate that research weaving methods add insights in support of and in addition to the original systematic map. We provide a methodological approach and discuss limitations related to applying bibliometric analyses to a previously published systematic map. We demonstrate the feasibility of this approach and its ability to enhance and enrich the findings gained from conventional systematic mapping techniques.
Inferring disease course from differential exon usage in the wide titinopathy spectrum
Authors: Di Feo Maria Francesca , Oghabian Ali , Nippala Ella , Gautel Mathias , Jungbluth Heinz , Forzano Francesca , Malfatti Edoardo , Castiglioni Claudia , Krey Ilona , Gomez Andres David , Brady Angela F. , Iascone Maria , Cereda Anna , Pezzani Lidia , Natera De Benito Daniel , Nascimiento Osorio Andres , Estévez Arias Berta , Kurbatov Sergei A. , Attie‐Bitach Tania , Nampoothiri Sheela , Ryan Erin , Morrow Michelle , Gorokhova Svetlana , Chabrol Brigitte , Sinisalo Juha , Tolppanen Heli , Tolva Johanna , Munell Francina , Camacho Soriano Jessica , Sanchez Duran Maria Angeles , Johari Mridul , Tajsharghi Homa , Hackman Peter , Udd Bjarne , Savarese Marco 
Published: August 2024

AbstractObjectiveBiallelic titin truncating variants (TTNtv) have been associated with a wide phenotypic spectrum, ranging from complex prenatal muscle diseases with dysmorphic features to adult‐onset limb‐girdle muscular dystrophy, with or without cardiac involvement. Given the size and complexity of TTN, reaching an unequivocal molecular diagnosis and precise disease prognosis remains challenging.MethodsIn this case series, 12 unpublished cases and one already published case with biallelic TTNtv were collected from multiple international medical centers between November 2022 and September 2023. TTN mutations were detected through exome or genome sequencing. Information about familial and personal clinical history was collected in a standardized form. RNA‐sequencing and analysis of TTN exon usage were performed on an internal sample cohort including postnatal skeletal muscles, fetal skeletal muscles, postnatal heart muscles, and fetal heart muscles. In addition, publicly available RNA‐sequencing data was retrieved from ENCODE.ResultsWe generated new RNA‐seq data on TTN exons and identified genotype–phenotype correlations with prognostic implications for each titinopathy patient (whether worsening or improving in prenatal and postnatal life) using percentage spliced in (PSI) data for the involved exons. Interestingly, thanks to exon usage, we were also able to rule out a titinopathy diagnosis in one prenatal case.InterpretationThis study demonstrates that exon usage provides valuable insights for a more exhaustive clinical interpretation of TTNtv; additionally, it may serve as a model for implementing personalized medicine in many other genetic diseases, since most genes undergo alternative splicing.
Clonal hematopoiesis in LGI1‐antibody encephalitis
Authors: Shin Soo Jean , Jang Yoonhyuk , Ahn Soo Hyun , Mon Su Yee , You Ji Hye , An Hong Yul , Sun Choong Hyun , Koh Youngil , Chu Kon , Lee Sang Kun , Lee Soon‐Tae 
Published: August 2024

AbstractObjectiveLeucine‐rich glioma‐inactivated 1 (LGI1)‐antibody encephalitis (LGI1e), the major form of autoimmune encephalitis (AE) presented with memory loss and faciobrachial dystonic seizure, commonly develops in aged population. Hematologic aging is often accompanied by clonal hematopoiesis (CH), a phenomenon in which specific mutations accumulate, potentially leading to autoimmune disorders or malignancies. Our research aimed to investigate the connection between clonal hematopoiesis of indeterminate potential (CHIP) and LGI1e.MethodsPeripheral blood samples from consecutive LGI1e patients were collected and analyzed for 24 clonal CHIP using targeted gene sequencing. The results were compared to a control dataset from an ethnically matched health care cohort. Patient characteristics were analyzed based on their CHIP status.ResultsA total of 52 LGI1e patients were enrolled for this study. Among them, three patients (5.8%) exhibited functional mutations in the ASXL1 gene, one of the CHIP‐associated genes analyzed by targeted sequencing. This frequency was significantly higher compared to that of the control cohort (1%, p = 0.015). Nevertheless, the patients showed no difference in the clinical characteristics, laboratory results, and immunotherapy outcomes.InterpretationLGI1e showed high frequency of ASXL1 functional mutation in the CHIP analysis, which may contribute to the underlying pathogenesis. Further research is needed to determine its direct role in the development of autoimmunity and disease progression.
Analysis of Glucose Responsive Glucagon Therapeutics using Computational Models of the Glucoregulatory System
Authors: Alizadehmojarad Ali A. , Yang Sungyun , Gong Xun , Strano Michael S. 
Published: August 2024

AbstractGlucose‐responsive glucagon (GRG) therapeutics are a promising technology for reducing the risk of severe hypoglycemia as a complication of diabetes mellitus. Herein, the performance of candidate GRGs in the literature by modeling the kinetics of activation and connecting them as input into physiological glucoregulatory models is evaluated and projected the two distinct GRG designs, experimental results reported in Wu et al. (GRG‐I) and Webber et al. (GRG‐II) is considered. Both are evaluated using a multi‐compartmental glucoregulatory model (IMPACT) and used to compare in‐vivo experimental data of therapeutic performance in rats and mice. For GRG‐I and GRG‐II, the total integrated glucose material balances are overestimated by 41.5% ± 14% and underestimated by 24.8% ± 16% compared to in‐vivo time‐course data, respectively. These large differences to the relatively simple computational descriptions of glucagon dynamics in the model, which underscores the urgent need for improved glucagon models is attributed. Additionally, therapeutic insulin and glucagon infusion pumps are modeled for type 1 diabetes mellitus (T1DM) human subjects to extend the results to additional datasets. These observations suggest that both the representative physiological and non‐physiological models considered in this work require additional refinement to successfully describe clinical data that involve simultaneous, coupled insulin, glucose, and glucagon dynamics.
Implantable Microneedle‐Mediated Eradication of Postoperative Tumor Foci Mitigates Glioblastoma Relapse
Authors: Zhang Yulin , Fang Zezheng , Liu Zejuan , Xi Kaiyan , Zhang Yi , Zhao Dawang , Feng Fan , Geng Humin , Liu Minglu , Lou Jingzhao , Chen Chen , Zhang Yanmin , Wu Zimei , Xu Feng , Jiang Xinyi , Ni Shilei 
Published: August 2024

AbstractGlioblastoma multiforme (GBM) remains incurable despite multimodal treatments after surgical debulking. Almost all patients with GBM relapse within a narrow margin (2–3 cm) of the initial resected lesion due to the unreachable residual cancerous cells. Here, a completely biodegradable microneedle for surgical cavity delivery glioblastoma‐associated macrophages (GAMs)‐activating immune nano‐stimulator that mitigates glioblastoma relapse is reported. The residual tumor lesion‐directed biocompatible microneedle releases the nano‐stimulator and toll‐like receptor 9 agonist in a controlled manner until the microneedles completely degrade over 1 week, efferently induce in situ phonotypic shifting of GAMs from anti‐ to pro‐inflammatory and the tumor recurrence is obviously inhibited. The implantable microneedles offer a significant improvement over conventional transdermal ones, as they are 100% degradable, ensuring safe application within surgical cavities. It is also revealed that the T cells are recruited to the tumor niche as the GAMs initiate anti‐tumor response and eradicate residual GBM cells. Taken together, this work provides a potential strategy for immunomodulating the postoperative tumor niche to mitigate tumor relapse in GBM patients, which may have broad applications in other malignancies with surgical intervention.
Regulating Aggregation‐Induced Emission Luminogen for Multimodal Imaging‐Navigated Synergistic Therapy Involving Anti‐Angiogenesis
Authors: Zhang Fei , Cui Jie , Zhang Yao , Yan Miao , Wu Xiaoxiao , Liu Xue , Yan Dingyuan , Zhang Zhijun , Han Ting , Tan Hui , Wang Dong , Tang Ben Zhong 
Published: August 2024

AbstractAs a new avenue for cancer research, phototheranostics has shown inexhaustible and vigorous vitality as it permits real‐time diagnosis and concurrent in situ therapy upon non‐invasive light‐initiation. However, construction of an advanced material, allowing prominent phototheranostic outputs and synchronously surmounting the inherent deficiency of phototheranostics, would be an appealing yet significantly challenging task. Herein, an aggregation‐induced emission (AIE)‐active luminogen (namely DBD‐TM) featured by intensive electron donor‐acceptor strength and twisted architecture with finely modulated intramolecular motion, is tactfully designed and prepared. DBD‐TM simultaneously possessed fluorescence emission in the second near‐infrared (NIR‐II) region and high‐efficiency photothermal conversion. By integrating DBD‐TM with anti‐angiogenic agent sorafenib, a versatile nanomaterial is smoothly fabricated and utilized for trimodal imaging‐navigated synergistic therapy involving photothermal therapy and anti‐angiogenesis toward cancer. This advanced approach is capable of affording accurate tumor diagnosis, complete tumor elimination, and largely restrained tumor recurrence, evidently denoting a prominent theranostic formula beyond phototheranostics. This study will offer a blueprint for exploiting a new generation of cancer theranostics.
Corrosion‐Resistant Ultrathin Cu Film Deposited on N‐Doped Amorphous Carbon Film Substrate and Its Use for Crumpleable Circuit Board
Authors: Shim Chae‐Eun , Lee Sangseob , Kong Minsik , Kim Ik‐Soo , Kwak Jaeik , Jang Woosun , Jeong Se‐Young , Kim Dong Wook , Soon Aloysius , Jeong Unyong 
Published: August 2024

AbstractCopper (Cu) is widely used as an industrial electrode due to its high electrical conductivity, mechanical properties, and cost‐effectiveness. However, Cu is susceptible to corrosion, which degrades device performance over time. Although various methods (alloying, physical passivation, surface treatment, etc.) are introduced to address the corrosion issue, they can cause decreased conductivity or vertical insulation. Here, using the nitrogen‐doped amorphous carbon (a‐C:N) thin film is proposed as a substrate on which Cu is directly deposited. This simple method significantly inhibits corrosion of ultrathin Cu (<20 nm) films in humid conditions, enabling the fabrication of ultrathin electronic circuit boards without corrosion under ambient conditions. This study investigates the origin of corrosion resistance through comprehensive microscopic/spectroscopic characterizations and density‐functional theory (DFT) calculations: i) diffusion of Cu atoms into the a‐C:N driven by stable C‐Cu‐N bond formation, ii) diffusion of N atoms from the a‐C:N to the Cu layer heading the top surface, which is the thermodynamically preferred location for N, and iii) the doped N atoms in Cu layer suppress the inclusion of O into the Cu lattice. By leveraging the ultrathinness and deformability of the circuit board, a transparent electrode and a crumpleable LED lighting device are demonstrated.
Mechanochemistry: Fundamental Principles and Applications
Authors: Dong Liang , Li Luofei , Chen Huiyan , Cao Yi , Lei Hai 
Published: August 2024

AbstractMechanochemistry is an emerging research field at the interface of physics, mechanics, materials science, and chemistry. Complementary to traditional activation methods in chemistry, such as heat, electricity, and light, mechanochemistry focuses on the activation of chemical reactions by directly or indirectly applying mechanical forces. It has evolved as a powerful tool for controlling chemical reactions in solid state systems, sensing and responding to stresses in polymer materials, regulating interfacial adhesions, and stimulating biological processes. By combining theoretical approaches, simulations and experimental techniques, researchers have gained intricate insights into the mechanisms underlying mechanochemistry. In this review, the physical chemistry principles underpinning mechanochemistry are elucidated and a comprehensive overview of recent significant achievements in the discovery of mechanically responsive chemical processes is provided, with a particular emphasis on their applications in materials science. Additionally, The perspectives and insights into potential future directions for this exciting research field are offered.
Light‐Activated Anti‐Vascular Combination Therapy against Choroidal Neovascularization
Authors: Xu Shuting , Li Jia , Long Kaiqi , Liang Xiaoling , Wang Weiping 
Published: August 2024

AbstractChoroidal neovascularization (CNV) underlies the crux of many angiogenic eye disorders. Although medications that target vascular endothelial growth factor (VEGF) are approved for treating CNV, their effectiveness in destroying new blood vessels is limited, and invasive intravitreal administration is required. Additionally, other drugs that destroy established neovessels, such as combretastatin A‐4, may have systemic side effects that limit their therapeutic benefits. To overcome these shortcomings, a two‐pronged anti‐vascular approach is presented for CNV treatment using a photoactivatable nanoparticle system that can release a VEGF receptor inhibitor and a vascular disrupting agent when irradiated with 690 nm light. The nanoparticles can be injected intravenously to enable anti‐angiogenic and vascular disrupting combination therapy for CNV through light irradiation to the eyes. This approach can potentiate therapeutic effects while maintaining a favorable biosafety profile for choroidal vascular diseases.