bluuebunny/crossref_metadata_2025_split huggingface dataset:
Placenta previa and risk of major congenital malformations among singleton births in Finland
Authors: Kancherla Vijaya , Räisänen Sari , Gissler Mika , Kramer Michael R. , Heinonen Seppo 
Published: March 2015

BACKGROUNDPlacenta previa has been associated with adverse birth outcomes, but its association with congenital malformations is inconclusive. We examined the association between placenta previa and major congenital malformations among singleton births in Finland.METHODSWe performed a retrospective population register‐based study on all singletons born at or after 22+0 weeks of gestation in Finland during 2000 to 2010. We linked three national health registers: the Finnish Medical Birth Register, the Hospital Discharge Register, and the Register of Congenital Malformations, and examined several demographic and clinical characteristics among women with and without placenta previa, in association with major congenital malformations. We estimated adjusted odds ratios and 95% confidence intervals using multivariable logistic regression models.RESULTSThe prevalence of placenta previa was estimated as 2.65 per 1000 singleton births in Finland (95% confidence interval, 2.53–2.79). Overall, 6.2% of women with placenta previa delivered a singleton infant with a major congenital malformation, compared with 3.8% of unaffected women (p ≤ 0.001). Placenta previa was positively associated with almost 1.6‐fold increased risk of major congenital malformations in the offspring, after controlling for maternal age, parity, fetal sex, smoking, socio‐economic status, chorionic villus biopsy, In vitro fertilization, pre‐existing diabetes, depression, preeclampsia, and prior caesarean section (adjusted odds ratio = 1.55; 95% confidence interval, 1.27–1.90).CONCLUSIONUsing a large population‐based study, we found that placenta previa was weakly, but significantly associated with an increased risk of major congenital malformations in singleton births. Future studies should examine the association between placenta previa and individual types of congenital malformations, specifically in high‐risk pregnancies. Birth Defects Research (Part A) 103:527–535, 2015. © 2015 Wiley Periodicals, Inc.
HDL particle subpopulations: Focus on biological function
Authors: Rached Fabiana H. , Chapman M. John , Kontush Anatol 
Published: March 2015

AbstractLow levels of high‐density lipoprotein‐cholesterol (HDL‐C) constitute an independent biomarker of cardiovascular morbi‐mortality. However, recent advances have drastically modified the classical and limited view of HDL as a carrier of ‘good cholesterol’, and have revealed unexpected levels of complexity in the circulating HDL particle pool. HDL particles are indeed highly heterogeneous in structure, intravascular metabolism and biological activity. This review describes recent progress in our understanding of HDL subpopulations and their biological activities, and focuses on relationships between the structural, compositional and functional heterogeneity of HDL particles. © 2015 BioFactors, 41(2):67–77, 2015
Modulation of cluster incorporation specificity in a de novo iron‐sulfur cluster binding peptide
Authors: Sommer Dayn Joseph , Roy Anindya , Astashkin Andrei , Ghirlanda Giovanna 
Published: March 2015

ABSTRACTiron‐sulfur cluster binding proteins perform an astounding variety of functions, and represent one of the most abundant classes of metalloproteins. Most often, they constitute pairs or chains and act as electron transfer modules either within complex redox enzymes or within small diffusible proteins. We have previously described the design of a three‐helix bundle that can bind two clusters within its hydrophobic core. Here, we use single‐point mutations to exchange one of the Cys ligands coordinating the cluster to either Leu or Ser. We show that the mutants modulate the redox potential of the clusters and stabilize the [3Fe‐4S] form over the [4Fe‐4S] form, supporting the use of model iron‐sulfur cluster proteins as modules in the design of complex redox enzymes. © 2015 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 104: 412–418, 2015.
A Comparison of Regulatory Awareness and Green Supply Chain Management Practices Among Chinese and Japanese Manufacturers
Authors: Zhu Qinghua , Qu Ying , Geng Yong , Fujita Tsuyoshi 
Published: March 2015

AbstractLeading manufacturers in developed countries generally have high environmental awareness and implement proactive environmental management practices such as green supply chain management (GSCM). However, it is uncertain if smaller manufacturers in developed countries are more proactive than all manufacturers in developing countries. To understand this situation, we carried out surveys among small and medium‐sized Japanese manufacturers, leading Chinese manufacturers and traditional Chinese manufacturers. Statistical results show that leading Chinese manufacturers have the highest awareness of both domestic and international environmental regulations/policies, and implement all GSCM practices at the highest level. Leading Chinese manufacturers and Japanese manufacturers are aware of international environmental regulations/policies, but such awareness only motivates them to implement eco‐design practices. Traditional Chinese manufacturers have limited awareness of international environmental regulations/policies, but such awareness brings all types of GSCM practice. Such results can be helpful for different manufacturers in both developed and developing countries to develop suitable environmental strategies. Copyright © 2015 John Wiley & Sons, Ltd and ERP Environment
Up‐regulation of miR‐26a promotes neurite outgrowth and ameliorates apoptosis by inhibiting PTEN in bupivacaine injured mouse dorsal root ganglia
Authors: Cui Changlei , Xu Gong , Qiu Jinpeng , Fan Xiushuang 
Published: March 2015

AbstractLocal anesthetic of bupivacaine may inhibit neurite outgrowth and induce apoptosis in mouse dorsal root ganglia (DRG) neurons. In this work, we intended to investigate the functional role of microRNA 26a (miR‐26a) in regulating bupivacaine‐induced nerve injury in DRG neurons. DRG neurons were extracted from C57BL/6 mice and cultured in vitro. Bupivacaine was applied in vitro and it induced apoptosis, inhibited neurite growth, and significantly down‐regulated miR‐26a gene in DRG neurons. MiR‐26a mimic was then used to up‐regulate miR‐26a expression in DRG neurons. We found that miR‐26a up‐regulation promoted neurite outgrowth and reduced apoptosis in bupivacaine‐injured DRG neurons. Luciferase assay and Western blot confirmed that Phosphatase and tensin homolog (PTEN) was down‐stream target of miR‐26a in DRG neurons. Ectopic PTEN up‐regulation was then able to reverse the protective effect of miR‐26a overexpression on bupivacaine‐induced nerve injury in DRG neurons. Overall, this work demonstrated that miR‐26a had a functional role in regulating bupivacaine‐induced nerve injury in DRG neurons. Up‐regulating miR‐26a to suppress PTEN signaling pathway may be an effective method to protect local anesthetic‐induced nerve injury in spinal cord.
Impact of gender on use of revascularization in acute coronary syndromes: The national observational study of diagnostic and interventional cardiac catheterization (ONACI)
Authors: Isorni Marc‐Antoine , Blanchard Didier , Teixeira Nelson , le Breton Hervé , Renault Nisa , Gilard Martine , Lefèvre Thierry , Mulak Geneviève , Danchin Nicolas , Spaulding Christian , Puymirat Etienne 
Published: March 2015

ObjectivesTo assess the impact of gender on myocardial revascularization using data collected in a French nationwide registry: the national observational study of diagnostic and interventional cardiac catheterization (ONACI).BackgroundGender differences in management of patients with acute coronary syndromes (ACS) have been reported.MethodsWe analysed data from a nationwide French prospective multicentre registry including 64,932 suspected ACS patients recruited in 99 centres from 2004 to 2008.ResultsOverall, women were older (70.7 ± 12.7 vs. 63.8 ± 12.9 years), had a higher cardiovascular risk profile, and were more frequently admitted with non ST‐elevation myocardial infarction or unstable angina (NSTEMI/UA) compared to men (73% vs. 68%). Women had significantly more angiographically normal coronary arteries or non‐significant coronary artery disease (CAD) in both STEMI (6% vs. 3%) and NSTEMI/UA (21% vs. 11%) while men had more severe CAD. After adjusting for age, cardiovascular risk factors, and extent of disease, myocardial revascularization (defined as the use of percutaneous coronary intervention (PCI) or coronary artery bypass grafting) was less frequently used in women (adjusted OR = 0.78; 95% CI: 0.77–0.83). For those receiving PCI, in‐hospital mortality within 24 hr of intervention was higher in women (3.6% vs. 1.2%; adjusted OR = 1.51; 95% CI: 1.22–1.87).ConclusionsIn the present study, despite having a higher cardiovascular risk profile, women more frequently had normal vessel/non‐significant angiographic coronary artery disease. In patients with significant coronary artery disease, myocardial revascularization was less frequently used in women whatever the type of ACS. © 2015 Wiley Periodicals, Inc.
An Amide‐Functionalized Dynamic Metal–Organic Framework Exhibiting Visual Colorimetric Anion Exchange and Selective Uptake of Benzene over Cyclohexane
Authors: Karmakar Avishek , Desai Aamod V. , Manna Biplab , Joarder Biplab , Ghosh Sujit K. 
Published: March 2015

AbstractA novel porous metal–organic framework (MOF) architecture is formed by a neutral amide‐functionalized ligand and copper(II). Upon desolvation, this compound undergoes a dynamic structural transformation from a one‐dimensional (1D) porous phase to a two‐dimensional (2D) non‐porous phase that shows selective uptake of benzene over cyclohexane. The as‐synthesized compound also acts as a visual colorimetric anion sensor for thiocyanate.
Emerging Thin‐Film Photovoltaic Technologies
Authors: Hermes Wilfried , Waldmann Daniel , Agari Michaela , Schierle‐Arndt Kerstin , Erk Peter 
Published: March 2015

AbstractWith free fuel from the sun, the cost of photovoltaic (PV) power is just related to conversion efficiency, lifetime and cost of the PV system. After successful optimization, crystalline silicon took the lead and a respectable PV market developed under the umbrella of subsidies. Thin‐film PV technologies provide the opportunity to reduce PV costs radically. They need less active material and their production processes are lean. In addition, flexibility, low weight and transparency will open new markets. This review gives an overview about the status of three emerging thin‐film technologies.
Approaching ultimate intrinsic SNR in a uniform spherical sample with finite arrays of loop coils
Authors: Vaidya Manushka V. , Sodickson Daniel K. , Lattanzi Riccardo 
Published: March 2015

ABSTRACTWe investigated to what degree and at what rate the ultimate intrinsic (UI) signal‐to‐noise ratio (SNR) may be approached using finite radiofrequency detector arrays. We used full‐wave electromagnetic field simulations based on dyadic Green's functions to compare the SNR of arrays of loops surrounding a uniform sphere with the ultimate intrinsic SNR (UISNR), for increasing numbers of elements over a range of magnetic field strengths, voxel positions, sphere sizes, and acceleration factors. We evaluated the effect of coil conductor losses and the performance of a variety of distinct geometrical arrangements such as “helmet” and “open‐pole” configurations in multiple imaging planes. Our results indicate that UISNR at the center is rapidly approached with encircling arrays and performance is substantially lower near the surface, where a quadrature detection configuration tailored to voxel position is optimal. Coil noise is negligible at high field, where sample noise dominates. Central SNR for practical array configurations such as the helmet is similar to that of close‐packed arrangements. The observed trends can provide physical insights to improve coil design. © 2015 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 44B: 53–65, 2015
Quadrature birdcage coil with distributed capacitors for 7.0 T magnetic resonance data acquisition of small animals
Authors: Stara Riccardo , Tiberi Gianluigi , Gabrieli Matteo , Buonincontri Guido , Fontana Nunzia , Monorchio Agostino , Costagli Mauro , Symms Mark Roger , Retico Alessandra , Tosetti Michela 
Published: March 2015

ABSTRACTHigh static magnetic field magnetic resonance imaging (MRI) is commonly used for preclinical studies in rodents. In this context, minimization of coil losses is mandatory to scan samples that are small compared to the radiofrequency wavelength in the medium. In this study we construct a radiofrequency (RF) birdcage probe with distributed capacitors, operating in quadrature, tailored for 7.0T 1H MRI of small animals. The design eliminates the need for extra electrical components on the probe structure and affords a high SNR, a uniform
field (homogeneity of 93% in the axial plain of the phantom) and a coil sensitivity of 9.8
. Feasibility experiments of mouse imaging are conducted and the competitive capability of a 7.0 T human system equipped with the proposed coil is demonstrated in both body and brain preclinical imaging. © 2015 Wiley Periodicals, Inc. Concepts Magn Reson Part B (Magn Reson Engineering) 44B: 83–88, 2015
Multiplex sequencing for EZH2, CD79B, and MYD88 mutations using archival cytospin preparations from B‐cell non‐Hodgkin lymphoma aspirates previously tested for MYC rearrangement and IGH/BCL2 translocation
Authors: da Cunha Santos Gilda , Saieg Mauro Ajaj , Ko Hyang Mi , Geddie William R. , Boerner Scott L. , Craddock Kenneth J. , Crump Michael , Bailey Denis 
Published: March 2015

BACKGROUNDGene rearrangements and specific translocations define some B‐cell non‐Hodgkin lymphoma (NHL) subtypes. Genome‐wide mutational studies have revealed recurrent point mutations with prognostic implications. The goals of this study were to evaluate the feasibility of applying a multiplex mutation assay to archival cytospin preparations (CPs) and to investigate the rate of EZH2, CD79B, and MYD88 mutations in B‐cell NHL samples previously tested for MYC rearrangement and/or IGH/BCL‐2 translocation.METHODSDNA was extracted from archival CPs of B‐cell NHL cases with previous fluorescence in situ hybridization (FISH) assays for MYC rearrangement and/or IGH/BCL‐2 translocation. Multiplex sequencing was performed for the detection of EZH2 (Y641), CD79B (Y196), and MYD88 (L265) mutations. Sanger sequencing was applied to samples with positive results and failed assays.RESULTSEighty‐eight archival CPs were available from 40 patients. Alterations detected by FISH were: MYC rearrangement (10 cases), IGH/BCL‐2 translocations (21 cases), dual translocations (6 cases), and other abnormalities for IGH/BCL‐2 (23 cases) and for MYC (16 cases). DNA concentration ranged from 1.88 to 62.85 ng/µL (mean, 9.46 ng/µL). Successful results were obtained in 88.0% of the specimens submitted to multiplex sequencing. With Sanger sequencing, 2 additional mutated cases were found, and all cases with mutations were confirmed. Eight specimens showed mutations: 6 for EZH2, 1 for CD79B, and 1 for MYD88. Among them, 5 cases showed concurrent MYC and/or IGH/BCL‐2 translocations and 2 revealed abnormal signals of IGH/BCL‐2 and MYC.CONCLUSIONSCPs archived for up to 6 years are a reliable source of high‐quality genomic material for multiplex sequencing. Almost all B‐cell NHL with point mutations showed concurrent chromosomal abnormalities. Cancer (Cancer Cytopathol) 2015;123:413‐20. © 2015 American Cancer Society.
Real‐time 2D visualization of metabolic activities in zebrafish embryos using a microfluidic technology
Authors: Zhu Feng , Baker Daniel , Skommer Joanna , Sewell Mary , Wlodkowic Donald 
Published: March 2015

AbstractNon‐invasive and real‐time visualization of metabolic activities in living small model organisms such as embryos and larvae of zebrafish has not yet been attempted largely due to profound analytical limitations of existing technologies. Historically, our capacity to examine oxygen gradients surrounding eggs and embryos has been severely limited, so much so that to date, most of the articles characterizing in situ oxygen gradients have described predominantly mathematical simulations. These drawbacks can, however, be experimentally addressed by an emerging field of microfluidic Lab‐on‐a‐Chip (LOC) technologies combined with sophisticated optoelectronic sensors. In this work, we outline a proof‐of‐concept approach utilizing microfluidic living embryo array system to enable in situ Fluorescence Ratiometric Imaging (FRIM) on developing zebrafish embryos. The FRIM is an innovative method for kinetic quantification of the temporal patterns of aqueous oxygen gradients at a very fine scale based on signals coming from an optical sensor referred to as a sensor foil. We envisage that future integration of microfluidic chip‐based technologies with FRIM represents a noteworthy direction to miniaturize and revolutionize research on metabolism and physiology in vivo. © 2015 International Society for Advancement of Cytometry
Sensory regulation of spontaneous limb movements in the midstage embryonic chick
Authors: Sharp Andrew A. 
Published: March 2015

ABSTRACTIt is becoming increasingly apparent that somatosensation plays an important role in regulating prenatal movement and developmental plasticity. Numerous studies performed on embryonic chicks and perinatal rats are beginning to implicate proprioception to be particularly important in modulating motility very soon after afferent connections are made in the spinal cord. In this report, we demonstrate new approaches in the chick embryo to explore the role of sensation in modulating embryonic movement. Force recordings from the legs of chick embryos on E9 and E11, during spontaneous motility, demonstrate changes in sensory regulation consistent with the concept that sensory regulation is functioning one day after sensory synapse formation and that the complexity of this regulation increases by E11. Additionally, we present new video data showing activation of embryonic motility on E5 and E9 in embryos expressing channelrhodopsin in the spinal cord as a novel way to approach the issues of sensorimotor development. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 385–396, 2015.
Quantitative single cell gene expression profiling in the avian embryo
Authors: Morrison Jason A. , Box Andrew C. , McKinney Mary C. , McLennan Rebecca , Kulesa Paul M. 
Published: March 2015

Background:Single cell gene profiling has been successfully applied to cultured cells. However, isolation and preservation of a cell's native gene expression state from an intact embryo remain problematic. Results: Here, we present a strategy for in vivo single cell profiling that optimizes cell identification, isolation and amplification of nucleic acids with nominal bias and sufficient material detection. We first tested several photoconvertible fluorescent proteins to selectively mark a cell(s) of interest in living chick embryos then accurately identify and isolate the same cell(s) in fixed tissue slices. We determined that the dual color mDendra2 provided the optimal signal/noise ratio for this purpose. We developed proper procedures to minimize cell death and preserve gene expression, and suggest nucleic acid amplification strategies for downstream analysis by microfluidic reverse transcriptase quantitative polymerase chain reaction or RNAseq. Lastly, we compared methods for single cell isolation and found that our fluorescence‐activated cell sorting (FACS) protocol was able to preserve native transcripts and generate expression profiles with much higher efficiency than laser capture microdissection (LCM). Conclusions: Quantitative single cell gene expression profiling may be accurately applied to interrogate complex cell dynamics events during embryonic development by combining photoconversion cell labeling, FACS, proper handling of isolated cells, and amplification strategies. Developmental Dynamics 244:774–784, 2015. © 2015 Wiley Periodicals, Inc.
Valuing preservation and restoration alternatives for ecosystem services in the southwestern USA
Authors: Broadbent Craig D. , Brookshire David S. , Goodrich David , Dixon Mark D. , Brand L. Arriana , Thacher Jennifer , Stewart Steve 
Published: March 2015

AbstractConservation of freshwater ecosystems in the semi‐arid southwestern USA is a critical issue as these systems support habitat for wildlife and provide consumptive use for humankind. Economists have utilized stated preference techniques to value non‐marketed goods and services such as freshwater ecosystems for much of the last four decades. Recently, Boyd and Banzhaf (2007) have advocated for ecosystem accounting units to be created in valuing ecosystem services such as freshwater ecosystems. Working collectively, a team of physical and social scientists developed a set of ecological endpoints for two river regions in the southwestern USA and used these ecological endpoints in a contingent valuation survey to obtain willingness to pay values for restoration and preservation alternatives. The results demonstrate statistically significant preservation and restoration estimates for the Upper San Pedro and restoration estimates for the Middle Rio Grande ecosystems. Copyright © 2015 John Wiley & Sons, Ltd.
External‐Template‐Assisted Formation of Octacyanometalate‐Based MV–MnII (M = W, Mo) Bimetallic Coordination Polymers with Magnetic Properties
Authors: Qian Jun , Hu Jingchun , Yoshikawa Hirofumi , Zhang Jinfang , Awaga Kunio , Zhang Chi 
Published: March 2015

AbstractThree manganese–molybdenum/tungsten bimetallic coordination polymers, two 2D {{[μ4‐M(CN)8]2[Mn(dmf)3]2[Mn(dmf)4]}·2DMF}n (M = W 1, Mo 2) and a 1D {{[μ4‐Mo(CN)8][Mn(dmf)4]2}·(ClO4)}n (3), were constructed from the reaction of the (Bu3NH)3[M(CN)8] (M = W, Mo) and Mn(ClO4)2·6H2O molecular building blocks in DMF solvent in the presence (for 1 and 2) or absence (for 3) of the organic ligand bis(benzimidazol‐2′‐yl)pyridine. Single‐crystal X‐ray diffraction structure analysis indicated that compounds 1 and 2 both crystallize in the monoclinic crystal system with the P21/c space group and possess the same 2D network. The 2D layer structures of 1 and 2 have a (3,4)‐connected 2‐nodal topology with the point symbol {42·63·8}{42·6}. Compound 3 crystallizes in the tetragonal crystal system with the P42/m space group. All three compounds are further assembled into 3D supramolecular structures through intermolecular C–H···N or C–H···O hydrogen bonds. The magnetic susceptibility of compounds 1 and 3 was investigated in the temperature range of 2–300 K; these compounds exhibit typical ferrimagnetic properties.