bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Open-Label, Single-Arm Pilot Study in Patients with Moderate to Severe Plaque-Type Psoriasis treated with Mesalazine
Authors: Narang Tarun , Handa Sanjeev 
Published: January 2014

ABSTRACT
Lipoxygenase inhibitors have been reported to have a therapeutic effect in psoriasis. Mesalazine, a lipoxygenase inhibitor, similar to sulfasalazine was tried in psoriasis. Patients with moderate to severe psoriasis were treated with mesalazine in a dose of 400 mg thrice a day for 8 weeks. Patients were assessed for disease activity at the start of therapy, at 4 weeks and at 8 weeks using the psoriasis area severity index (PASI). Twenty-one patients (18 males and 3 females) of stable plaque psoriasis with a mean age of 42.3 years were included in the study. Duration of disease ranged from 3 months to 30 years. Mean body surface area involved was 36.3%. Of 19 patients who completed the study, 7 (36.8%) had ≥40% decline in PASI. Two patients did not respond to therapy. Mean baseline PASI decreased from 16.2 to 13.2 at 4 weeks and 10.1 at 8 weeks (p < 0.01). Both the values were statistically significant. Mesalazine can prove to be a significant addition or adjunct to the systemic therapies available for the treatment of psoriasis.

How to cite this article
Handa S, Narang T. An Open-Label, Single-Arm Pilot Study in Patients with Moderate to Severe Plaque-Type Psoriasis treated with Mesalazine. J Postgrad Med Edu Res 2014;48(1):24-26.
Sublingual vs Oral Misoprostol for Labor Induction
Authors: Bagga Rashmi , Siwatch Sujata , Kalra Jasvinder , Doke Goter 
Published: January 2014

ABSTRACT

Background
This study compares the eficacy and safety of sublingual vs oral misoprostol for induction of labor.

Materials and methods
160 women admitted for induction of labor at the Postgraduate Institute of Medical Education and Research, Chandigarh were randomized to receive 25 µg misoprostol orally 3 hourly or 25 µg sublingual misoprostol 4 hourly for labor induction.

Outcome
The two groups were compared for number of women not delivered in 24 hours, misoprostol dose required, induction delivery interval, incidence of uterine contraction abnormalities, mode of delivery, side effects and neonatal outcomes.

Results
Low dose of misoprostol is eficacious with both routes of administration. Majority women delivered vaginally and of them, comparable numbers in both vaginal and sublingual misoprostol groups delivered within 24 hours of induction (93.1 and 83.7%). The sublingual route is associated with a statistically signiicant lesser induction to delivery interval (14.8 ± 6.2 hours vs 17.67 ± 7.32 hours) and lesser requirement of oxytocin augmentation (62.5 vs 35%). The occurrence of uterine contraction abnormalities and neonatal outcome was similar in both groups.

Conclusion
The low dose of 25 µg is eficacious and safe by both sublingual and oral routes. Sublingual route has lesser induction to delivery interval and lesser requirement for oxytocin augmentation.

How to cite this article
Siwatch S, Doke G, Kalra J Bagga R. Sublingual vs Oral Misoprostol for Labor Induction. J Postgrad Med Edu Res 2014;48(1):33-36.
Unilateral Hypoplasia of Lung in Association with Dilated Stomach
Authors: Kasilingam Sangeeth Kumar , Jindal Savita 
Published: January 2014

ABSTRACT
Human lung growth starts as a primitive lung bud in early embryonic life and its growth is determined by various factors which occur during development. Pressure effects during intrauterine life from neighboring organs can impede the growth and lead to a hypoplastic lung. These could be due to associated congenital abnormalities of diaphragm, kidney, heart, GIT, etc. Dilated stomach is a rare association with a hypoplastic lung. We describe a case of congenital unilateral pulmonary hypoplasia in association with dilated stomach in a 25-year-old man who presented with exacerbation of bronchial asthma.

How to cite this article
Kasilingam SK, Jindal S. Unilateral Hypoplasia of Lung in Association with Dilated Stomach. J Postgrad Med Edu Res 2014;48(1):40-42.
Metastatic Adenoid Cystic Carcinoma of Prostate: Is Androgen Deprivation Therapy Beneficial?
Authors: Bal Amanjit , Singh Shrawan K , Gnanasekharan Madhusudhanan , Ganesamoni Raguram , Kumar Santosh 
Published: January 2014

ABSTRACT
Adenoid cystic carcinoma of prostate is a rare malignancy arising from basal cells of prostatic acini. The management of metastatic adenoid cystic carcinoma of prostate is not well defined because of its rarity. We report a 68-year-old male presented with acute urinary retention and pain in left hip region. Digital rectal examination revealed a hard nodular prostate with extension to the lateral pelvic walls. His serum PSA was 0.15 ng/ml. Transrectal ultrasound (TRUS) guided prostate biopsy revealed adenoid cystic carcinoma. Bone scan showed metastasis in left acetabulum. He underwent channel transurethral resection of prostate and bilateral orchiectomy. He received palliative radiotherapy for left acetabular metastasis to control his pain. At 3 years of follow-up, the patient is doing well with no new metastasis. Hormone therapy is a viable option in patients with metastatic adenoid cystic carcinoma of prostate.

How to cite this article
Singh SK, Gnanasekharan M, Kumar S, Ganesamoni R, Bal A. Metastatic Adenoid Cystic Carcinoma of Prostate: Is Androgen Deprivation Therapy Beneficial. J Postgrad Med Edu Res 2014;48(1):43-45.
Estudio del equilibrio y cinética de adsorción de Cd(II), Ni(II) y Cr(VI) usando Quitosano y Quitosano modificado con cobre
Authors: Castro S. , Cerda R. , Betanco N. , Canelo F. , López X. , García A. , Benavente M. 
Published: January 2014

En este trabajo, se estudió el equilibrio y la cinética de adsorción de Cd(II), Ni(II) en quitosano y Cr(VI) en quitosano modificado con cobre. Para ello, soluciones de iones metálicos a diferentes concentraciones, fueron puestas en contacto con el adsorbente y se agitaron por un período de 3 – 4 h. Al final del proceso, las muestras fueron analizadas en un espectrómetro de absorción atómica. Los datos experimentales del equilibrio de adsorción de los iones metálicos fueron evaluados aplicando las isotermas de Langmuir y Freundlich; mientras los datos cinéticos fueron evaluados utilizando los modelos cinéticos de pseudo-primer orden y pseudo-segundo orden. Los resultados del proceso demostraron que los iones fueron eficazmente adsorbidos por el quitosano (Cd y Ni) y por el Cu-quitosano (Cr). Además, se comprobó que los datos experimentales del equilibrio de adsorción de Cr(VI) y Ni(II) se ajustan al modelo de Langmuir; mientras que los datos experimentales del Cd(II) fueron mejor ajustados por el modelo de Freundlich. Mediante el uso de la isoterma de Langmuir se determinó la capacidad máxima de adsorción de cromo (29.7 mg/g Cu-quitosano), cadmio (102.0 mg/g quitosano) y níquel (83.31 mg/g quitosano). Los resultados de la cinética de adsorción de los iones metálicos mostraron que los datos experimentales fueron mejor ajustados por el modelo de pseudo-segundo orden; es decir, el paso limitante en la velocidad es la reacción de adsorción y no la transferencia de masa. DOI: http://dx.doi.org/10.5377/nexo.v26i2.1285 Nexo Revista Científica Vol. 26, No. 02, pp. 56-68/Diciembre 2013
Global Labor Justice and the Limits of Economic Analysis
Authors: Preiss Joshua 
Published: January 2014

ABSTRACT:This article considers the economic case for so-called sweatshop wages and working conditions. My goal is not to defend or reject the economic case for sweatshops. Instead, proceeding from a broadly pluralist understanding of value, I make and defend a number of claims concerning the ethical relevance of economic analysis for values that different agents utilize to evaluate sweatshops. My arguments give special attention to a series of recent articles by Benjamin Powell and Matt Zwolinski, which represent the latest and best defense of the economic case for sweatshops. In the process, I challenge Zwolinski’s “non-worseness claim” (NWC), and the idea that opposition to sweatshop wages and working conditions fails to respect that the autonomy of would-be sweatshop workers. Ultimately, I conclude that even if the economic case for sweatshops rests on a solid empirical foundation, agents possess good reason to advocate for better wages and working conditions for sweatshop workers, and to prefer less exploitative or coercive relationships. Sweatshop labor undermines a compelling vision of free markets, according to both Kantian and republican conceptions of freedom, and the relationships formed by those who participate in such markets.
Lipoidic Cells Ovary Cancer, Clinic Case and Literature Review
Authors: Arturo Novoa Vargas  , Karla Sánchez Bautista  , Ismael Coudillo Luna  
Published: January 2014

Objective:Analyzed a case of woman with virilizan ovary tumor, where clinics manifestations made easy diagnosis of a anexial tumor producing masculine hormones with neoplastic thorax effusion and ascites. Specific tumoral serum marks for diagnosis, and posoperatory evolution. We made a medical prospective literature review.
Methods:We studied a female case 35 years old, with an androgenic malignity ovary tumor, Analysis was worked ina Regional General Hospital of a State of Mexico, Mexico last year. Prospective studying a tumor of the ovary, produces masculine hormones.
Discussion:Rare tumor, represents, almost 0.5% all ovarian tumors. Its secrets masculine hormones; with broaden voice, acne, facial and corporal hair increased, large clitoris, androgenic calvicie patter. Those tumors grow in all ages women groups, but usually in young women, almost is unilateral (95%). We show a clinical case of woman, 35 years old with androgenic dates, She carried out surgery for ovarian tumor. Histopathology report confirmed a malign ovary cordons sexual cells, with high malign grade compound, approximated 30 cm mayor diameter with integral capsule. Stage IC. Were used 6 cycles intravenous systemic chemotherapy. At present, her tumoral marks are negative and gradually have been disappeared androgenic clinical manifestations.
Conclusions:Rare malign ovary tumor, produces androgenic clinical manifestation. Grove up tumor marks like serum testosterone; cytorreductive surgery is cornerstone treatment. Prognosis disease is up to grade of cell differentiation and stage in surgical-pathological events. Five years survive in stage I, is approximate in 70 to 90% of cases.
Diseño, imagen y comunicación de productos de lujo. Estudio arquetípico de los atributos esenciales para su identificación
Authors: López María Aurora López , Martín Isabel Rodrigo , Martín Luis Rodrigo 
Published: January 2014

Palabras clave: diseño, imagen, comunicación, lujo, atributos arquetípicos.Resumen: El estudio de un fenómeno multidisciplinar como lo es el concepto de “lujo” en la actualidad, dada su dimensión económica, social y cultural, nos ofrece un interesante enfoque desde el que abordar con gran pragmatismo la realidad. De este modo, la presente investigación indaga en los entresijos de toda su industria, mediante una profundización en el conocimiento de los atributos identificativos que permiten averiguar el índice de pertenencia de los diferentes bienes y servicios del mercado con respecto a dicho universo categórico, construyendo una matriz arquetípica que con determinación establece las pautas necesarias para ello, y cuya extrapolación a otros ámbitos de índole diferente es tan factible que, de transferírseles dichos atributos, podrían no sólo enriquecerse, sino mejorarse en la línea acertada que exige nuestra nueva era de consumo tecnológico y producción digital.Keywords: design, image, communication, luxury, archetypal attributes.Abstract: The study of a multidisciplinary phenomenon as is the concept of "luxury" at present, given its economic, social and cultural, offers an interesting approach from which deal with great pragmatism our reality. Thus, this research explores the intricacies of all its industry, through a deeper knowledge of identifying attributes that find out the membership rate of different market goods and services with respect to such categorical universe, developing an archetypal head mould that establishes guidelines determination necessary for this, and whose extrapolation to other areas of a different nature is as likely that, these attributes transferred to them, could not only rich, but improved in the correct line that demands our new era of technological consumption and digital production.
Quantifying hiss‐driven energetic electron precipitation: A detailed conjunction event analysis
Authors: Li W. , Ni B. , Thorne R. M. , Bortnik J. , Nishimura Y. , Green J. C. , Kletzing C. A. , Kurth W. S. , Hospodarsky G. B. , Spence H. E. , Reeves G. D. , Blake J. B. , Fennell J. F. , Claudepierre S. G. , Gu X. 
Published: January 2014

AbstractWe analyze a conjunction event between the Van Allen Probes and the low‐altitude Polar Orbiting Environmental Satellite (POES) to quantify hiss‐driven energetic electron precipitation. A physics‐based technique based on quasi‐linear diffusion theory is used to estimate the ratio of precipitated and trapped electron fluxes (R), which could be measured by the two‐directional POES particle detectors, using wave and plasma parameters observed by the Van Allen Probes. The remarkable agreement between modeling and observations suggests that this technique is applicable for quantifying hiss‐driven electron scattering near the bounce loss cone. More importantly, R in the 100–300 keV energy channel measured by multiple POES satellites over a broad L magnetic local time region can potentially provide the spatiotemporal evolution of global hiss wave intensity, which is essential in evaluating radiation belt electron dynamics, but cannot be obtained by in situ equatorial satellites alone.
Measuring miscible fluid displacement in porous media with magnetic resonance imaging
Authors: Muir Colleen E. , Petrov Oleg V. , Romanenko Konstantin V. , Balcom Bruce J. 
Published: January 2014

AbstractThe development of new quantitative magnetic resonance imaging (MRI) technologies open new opportunities for measurements of mass transport in porous media. The current work examines a simple miscible displacement process of H2O and D2O in porous media samples. Laboratory measurements of dispersion in porous media traditionally monitor the effluent intensity of an injected tracer. We employ MRI to obtain quantitative water saturation profiles, and to measure dispersion in rock core plugs. The saturation profiles are modeled with PHREEQC, a fluid transport modeling program. We demonstrate how independent magnetic resonance measurements can be employed to estimate three important input parameters for PHREEQC, mobile porosity, immobile porosity, and dispersivity. Bulk Carr Purcell Meiboom Gill (CPMG) T2 distribution measurements were undertaken to estimate mobile and immobile porosity. Bulk alternating‐pulsed‐gradient‐stimulated‐echo (APGSTE) measurements were undertaken to measure dispersivity. The imaging method employed, T2 mapping Spin Echo Single Point Imaging (SE‐SPI), also provides information about the pore size distributions in the rock cores, and how the fluid occupancy of the pores changes during the displacement process.
Criminology and Public Policy
Authors: Fagan Abigail A. 
Published: January 2014

AbstractThere has historically been a large gap between criminology and public policies intended to reduce crime and incarceration. Many criminal justice practices have not been based on scientific information about what causes crime or how to reduce it. In turn, many practices routinely used to control crime have not been effective in reducing individuals' likelihood of offending. While the need to create evidence‐based policies and practices is being increasingly recognized, and there are signs that the gap between research and practice is shrinking, additional efforts need to be made in order to significantly impact on rates of crime and incarceration. This entry provides examples of (largely ineffective) practices that are not based on scientific information as well as evidence‐based policies with more potential to affect crime rates, and outlines steps for ensuring increased collaboration and communication between academics, policy makers, and practitioners.
Felson, Marcus
Authors: Medina José E. 
Published: January 2014

Abstract
Marcus Felson is one of the most cited authors of the late twentieth and early twenty‐first centuries. His greatest impact has been in the area of criminology in general and crime science in particular because of his formulation and later development of routine activities theory. Initially established in the area of predatory crime and later extended to other categories of crime such as sex crimes or cybercrime, it is considered the foundation of what would come to be known as opportunity theories.
Direkte Modulation von Rab‐GTPase‐Effektor‐Wechselwirkungen
Authors: Spiegel Jochen , Cromm Philipp M. , Itzen Aymelt , Goody Roger S. , Grossmann Tom N. , Waldmann Herbert 
Published: January 2014

AbstractKleine GTPasen fungieren als molekulare Schalter bei der Kontrolle zahlreicher essenzieller zellulärer Prozesse. Während eine fehlerhafte Funktion oder Regulierung von GTPasen in einer Vielzahl von humanen Erkrankungen eine wichtige Rolle spielt, hat es sich als schwierig erwiesen, diese Proteinklasse direkt zu adressieren, da ihre Regulierung und biologische Wirkung über ausgedehnte und gering profilierte Proteinoberflächen vermittelt werden. Hier beschreiben wir die Entwicklung von Inhibitoren für Protein‐Protein‐Wechselwirkungen von Rab‐GTPasen, die eine Schlüsselrolle bei der Regulation vesikulärer Transportprozesse spielen. Auf der Basis von Kristallstrukturen von Rab‐Proteinen gebunden an ihre Wechselwirkungspartner wurden so genannte “stapled peptides” entwickelt. Diese Peptide zeichnen sich durch signifikant gesteigerte Affinitäten aus. Eines der modifizierten Peptide, StRIP3, bindet selektiv an aktives Rab8a und inhibiert eine Rab8a‐Effektor‐Wechselwirkung in vitro.
Organozinc Pivalate Reagents: Segregation, Solubility, Stabilization, and Structural Insights
Authors: Hernán‐Gómez Alberto , Herd Emma , Hevia Eva , Kennedy Alan R. , Knochel Paul , Koszinowski Konrad , Manolikakes Sophia M. , Mulvey Robert E. , Schnegelsberg Christoph 
Published: January 2014

AbstractThe pivalates RZnOPiv⋅Mg(OPiv)X⋅n LiCl (OPiv=pivalate; R=aryl; X=Cl, Br, I) stand out amongst salt‐supported organometallic reagents, because apart from their effectiveness in Negishi cross‐coupling reactions, they show more resistance to attack by moist air than conventional organometallic compounds. Herein a combination of synthesis, coupling applications, X‐ray crystallographic studies, NMR (including DOSY) studies, and ESI mass spectrometric studies provide details of these pivalate reagents in their own right. A p‐tolyl case system shows that in [D8]THF solution these reagents exist as separated Me(p‐C6H4)ZnCl and Mg(OPiv)2 species. Air exposure tests and X‐ray crystallographic studies indicate that Mg(OPiv)2 enhances the air stability of aryl zinc species by sequestering H2O contaminants. Coupling reactions of Me(p‐C6H4)ZnX (where X=different salts) with 4‐bromoanisole highlight the importance of the presence of Mg(OPiv)2. Insight into the role of LiCl in these multicomponent mixtures is provided by the molecular structure of [(THF)2Li2(Cl)2(OPiv)2Zn].
Aufspaltung des Wellenpakets und Doppelpfad‐Desaktivierung im photoangeregten Sehpigment Isorhodopsin
Authors: Polli Dario , Weingart Oliver , Brida Daniele , Poli Emiliano , Maiuri Margherita , Spillane Katelyn M. , Bottoni Andrea , Kukura Philipp , Mathies Richard A. , Cerullo Giulio , Garavelli Marco 
Published: January 2014

AbstractIsorhodopsin ist ein dem Rhodopsin analoges Sehprotein. Es hat die gleiche Opsin‐Umgebung, bindet aber statt 11‐cis‐Retinal die 9‐cis‐Form. Dessen Photoisomerisierung ist etwa dreimal langsamer und viel weniger effizient. Das dafür zugrundeliegende mechanistische Prinzip wird hier mit einer Kombination aus quantenmechanischen/molekülmechanischen Simulationen und ultraschneller optischer Spektroskopie mit Sub‐20‐fs‐Auflösung und einem Spektralbereich bis ins nahe Infrarot aufgedeckt. Während sich das photoangeregte Wellenpaket im Rhodopsin zielgerichtet durch eine einzelne konische Durchschneidung zwischen dem angeregten und dem Grundzustand bewegt, spaltet es im Isorhodopsin auf und beschreitet zwei konkurrierende Desaktivierungspfade mit unterschiedlichen Reaktionstrichtern. Einer wird schnell erreicht, ist aber im Wesentlichen unproduktiv. Der andere Pfad ist aufgrund erhöhter sterischer Wechselwirkungen mit der Umgebung verlangsamt, führt aber entlang eine “Vorwärts”‐Pedalbewegung zum Photoprodukt.
Spectroscopic and Computational Study of a Nonheme Iron Nitrosyl Center in a Biosynthetic Model of Nitric Oxide Reductase
Authors: Chakraborty Saumen , Reed Julian , Ross Matthew , Nilges Mark J. , Petrik Igor D. , Ghosh Soumya , Hammes‐Schiffer Sharon , Sage J. Timothy , Zhang Yong , Schulz Charles E. , Lu Yi 
Published: January 2014

AbstractA major barrier to understanding the mechanism of nitric oxide reductases (NORs) is the lack of a selective probe of NO binding to the nonheme FeB center. By replacing the heme in a biosynthetic model of NORs, which structurally and functionally mimics NORs, with isostructural ZnPP, the electronic structure and functional properties of the FeB nitrosyl complex was probed. This approach allowed observation of the first S=3/2 nonheme {FeNO}7 complex in a protein‐based model system of NOR. Detailed spectroscopic and computational studies show that the electronic state of the {FeNO}7 complex is best described as a high spin ferrous iron (S=2) antiferromagnetically coupled to an NO radical (S= 1/2) [Fe2+‐NO.]. The radical nature of the FeB‐bound NO would facilitate NN bond formation by radical coupling with the heme‐bound NO. This finding, therefore, supports the proposed trans mechanism of NO reduction by NORs.
Solid‐Phase Incorporation of an ATRP Initiator for Polymer–DNA Biohybrids
Authors: Averick Saadyah E. , Dey Sourav K. , Grahacharya Debasish , Matyjaszewski Krzysztof , Das Subha R. 
Published: January 2014

AbstractThe combination of polymers with nucleic acids leads to materials with significantly advanced properties. To obviate the necessity and complexity of conjugating two macromolecules, a polymer initiator is described that can be directly covalently linked to DNA during solid‐phase synthesis. Polymer can then be grown from the DNA bound initiator, both in solution after the DNA‐initiator is released from the solid support as well as directly on the solid support, simplifying purification. The resulting polymer‐DNA hybrids were examined by chromatography and fluorescence methods that attested to the integrity of hybrids and the DNA. The ability to use DNA‐based supports expands the range of readily available molecules that can be used with the initiator, as exemplified by direct synthesis of a biotin polymer hybrid on solid‐support. This method expands the accessibility and range of advanced polymer biohybrid materials.
Total Synthesis of the Monoterpenoid Indole Alkaloid (±)‐Aspidophylline A
Authors: Teng Mingxing , Zi Weiwei , Ma Dawei 
Published: January 2014

AbstractAspidophylline A belongs to the akuammiline alkaloid family, the members of which possess intriguing cagelike structures and diverse biological activities. Herein we report a 15‐step synthesis of this alkaloid from conveniently available starting materials. The key elements of the synthesis include an intramolecular oxidative coupling to create the tetracyclic furoindoline motif of the natural product and a [Ni(cod)2]‐mediated cyclization to install its piperidine ring.