bluuebunny/crossref_metadata_2025_split huggingface dataset:
Degradation of Poly(ε-caprolactone) by thermophilic Streptomyces thermoviolaceus subsp. thermoviolaceus 76T-2
Authors: Chua Te-Kuan , Tseng Min , Yang Mei-Kwei 
Published: January 2013

Abstract
A thermophilic Streptomyces thermoviolaceus subsp. thermoviolaceus isolate 76T-2 that can degrade poly(ε-caprolactone) (PCL) was isolated from soil in Taiwan. Isolate 76T-2 grew well in urea fructose oatmeal medium and exhibited clear zones on agar plates containing PCL, indicating the presence of extracellular PCL depolymerases. The PCL powder present in culture medium was completely degraded within 6 h of culture at 45°C. Two PCL-degrading enzymes were purified to homogeneity from the culture supernatant. The molecular weights of these two enzymes were estimated to be 25 kDa and 55 kDa, respectively. A portion of the N-terminal region of the 25-kDa protein was determined, and the sequence Ala-Asn-Phe-Val-Val-Ser-Glu-Ala thus obtained was identical to that of A64-A71 of the Chi25 chitinase of Streptomyces thermoviolaceus OPC-520. The 25-kDa protein was shown to also degrade chitin, suggesting that isolate 76T-2 has the ability to degrade both PCL and chitin.
Sex Differences in the Return-to-Work Process of Cancer Survivors 2 Years After Diagnosis: Results From a Large French Population-Based Sample
Authors: Marino Patricia , Luis Sagaon Teyssier , Laetitia Malavolti , Anne-Gaelle Le Corroller-Soriano 
Published: January 2013

Purpose To investigate the effects of clinical, sociodemographic, and occupational factors on time to return to work (RTW) during the 2 years after cancer diagnosis and to analyze whether sex differences exist. Patients and Methods This study was based on a French national cross-sectional survey involving 4,270 cancer survivors. Time to RTW was estimated through the duration of sick leave of 801 cancer survivors younger than 58 years who were employed during the 2-year survey. Multivariate analysis of the RTW after sick leave was performed using a Weibull accelerated failure time model. Results We found some sex differences in the RTW process. Older men returned to work more slowly than older women (P = .013), whereas married men returned to work much faster than married women (P = .019). Duration dependence was also sex-specific. In men, the time spent on sick leave was independent of the probability of returning to work, whereas in women, this duration dependence was positive (P < .001). For both men and women, clinical factors including chemotherapy, adverse effects, and cancer severity were found to delay RTW (P = .035, P = .001, and P < .001, respectively). Survivors investing most strongly in their personal lives also delayed their RTW (P = .006), as did those with a permanent work contract (P = .042). The factor found to accelerate RTW was a higher educational level (P = .014). Conclusion The RTW process 2 years after cancer diagnosis differed between men and women. A better knowledge of this process should help the national implementation of more cost-effective strategies for managing the RTW of cancer survivors.
Specificity of Problem-Solving Skills Training in Mothers of Children Newly Diagnosed With Cancer: Results of a Multisite Randomized Clinical Trial
Authors: Sahler Olle Jane Z. , Dolgin Michael J. , Phipps Sean , Fairclough Diane L. , Askins Martha A. , Katz Ernest R. , Noll Robert B. , Butler Robert W. 
Published: January 2013

Purpose Diagnosis of cancer in a child can be extremely stressful for parents. Bright IDEAS, a problem-solving skills training (PSST) intervention, has been shown to decrease negative affectivity (anxiety, depression, post-traumatic stress symptoms) in mothers of newly diagnosed patients. This study was designed to determine the specificity of PSST by examining its direct and indirect (eg, social support) effects compared with a nondirective support (NDS) intervention. Patients and Methods This randomized clinical trial included 309 English- or Spanish-speaking mothers of children diagnosed 2 to 16 weeks before recruitment. Participants completed assessments prerandomization (T1), immediately postintervention (T2), and at 3-month follow-up (T3). Both PSST and NDS consisted of eight weekly 1-hour individual sessions. Outcomes included measures of problem-solving skill and negative affectivity. Results There were no significant between-group differences at baseline (T1). Except for level of problem-solving skill, which was directly taught in the PSST arm, outcome measures improved equally in both groups immediately postintervention (T2). However, at the 3-month follow-up (T3), mothers in the PSST group continued to show significant improvements in mood, anxiety, and post-traumatic stress; mothers in the NDS group showed no further significant gains. Conclusion PSST is an effective and specific intervention whose beneficial effects continue to grow after the intervention ends. In contrast, NDS is an effective intervention while it is being administered, but its benefits plateau when active support is removed. Therefore, teaching coping skills at diagnosis has the potential to facilitate family resilience over the entire course of treatment.
Two-Year Randomized Controlled Prospective Trial Converting Treatment of Stable Renal Transplant Recipients With Cutaneous Invasive Squamous Cell Carcinomas to Sirolimus
Authors: Hoogendijk-van den Akker Judith M. , Harden Paul N. , Hoitsma Andries J. , Proby Charlotte M. , Wolterbeek Ron , Bouwes Bavinck Jan Nico , de Fijter Johan W. 
Published: January 2013

Purpose In light of the significant morbidity and mortality of cutaneous invasive squamous cell carcinomas (SCCs) in renal transplant recipients, we investigated whether conversion to sirolimus-based immunosuppression from standard immunosuppression could diminish the recurrence rate of these skin cancers. Patients and Methods In a 2-year randomized controlled trial, 155 renal transplant recipients with at least one biopsy-confirmed SCC were stratified according to age (< 55 v ≥ 55 years) and number of previous SCCs (one to nine v ≥ 10) and randomly assigned to conversion to sirolimus (n = 74) or continuation of their original immunosuppression (n = 81). Development of a new SCC within 2 years after random assignment was the primary end point. Results After 2 years of follow-up, the risk reduction of new SCCs in the multivariable analysis was not significant, with a hazard ratio (HR) of 0.76 (95% CI, 0.48 to 1.2; P = .255), compared with a non–sirolimus-based regimen. After the first year, there was a significant 50% risk reduction, with an HR of 0.50 (95% CI, 0.28 to 0.90; P = .021) for all patients together and an HR of 0.11 (95% CI, 0.01 to 0.94; P = .044) for patients with only one previous SCC. The tumor burden of SCC was reduced during the 2-year follow-up period in those receiving sirolimus (0.82 v 1.38 per year; HR, 0.51; 95% CI, 0.32 to 0.82; P = .006) if adjusted for the number of previous SCCs and age. Twenty-nine patients stopped taking sirolimus because of various adverse events. Conclusion Conversion to sirolimus-based immunosuppression failed to show a benefit in terms of SCC-free survival at 2 years.
Sourcing for Supplier Effort and Competition: Design of the Supply Base and Pricing Mechanism
Authors: Li Cuihong 
Published: January 2013

We study a buyer's sourcing strategy along two dimensions: the supply base design and the pricing mechanism, considering supplier competition and cost-reduction effort. The supply base design concerns the number of suppliers (one or two) included in the supply base and the capacity to be invested in each supplier. The pricing mechanism determines the timing of the price decisions, with the buyer making price commitments before suppliers exert cost-reduction efforts that may be renegotiated afterward. We find that symmetric capacity investment in suppliers and low price commitments (more likely to be renegotiated) are effective at fostering supplier competition, whereas asymmetric investment and high price commitments (less likely to be renegotiated) are better at motivating supplier effort. A complementary relationship exists between the supply base design and pricing mechanism: A more symmetric supply base should be combined with lower price commitments, leading to more renegotiation opportunities. This results in three possible sourcing structures: sole sourcing (investing capacity in a single supplier and forming price with ex ante commitments), symmetric dual sourcing (investing equal capacity in both suppliers and forming price with ex post negotiations), and asymmetric dual sourcing (investing positive but unequal capacities in two (ex ante identical) suppliers and forming price using both ex ante commitments and ex post (re)negotiations). We characterize the conditions for each structure and identify a strategic role of capacity investment.This paper was accepted by Martin Lariviere, operations management.
Does Pooling Purchases Lead to Higher Profits?
Authors: Hu Bin , Duenyas Izak , Beil Damian R. 
Published: January 2013

Consider two buyers facing uncertain demands who need to purchase a common critical component from a powerful sole-source supplier. If the two buyers pool their demands and purchase from the supplier as a single entity, will they necessarily earn higher profits than purchasing separately? We show that when a powerful supplier extracts profits from the buyers through optimal contract design, the demand variability reduction achieved by pooling can harm the buyers because it makes extracting profits easier for the supplier. We characterize cases when pooling is disadvantageous and also provide insights into when it is still advantageous. Our result is in contrast to the case where the price of the component is exogenous (typically assumed in most of the pooling literature), in which case pooling demands is always beneficial for the buyers. This paper was accepted by Yossi Aviv, operations management.
Feasibility of Eight Physical Fitness Tests in 1,050 Older Adults with Intellectual Disability: Results of the Healthy Ageing with Intellectual Disabilities Study
Authors: Hilgenkamp Thessa I. M. , van Wijck Ruud , Evenhuis Heleen M. 
Published: January 2013

AbstractAlthough physical fitness is relevant for well-being and health, knowledge on the feasibility of instruments to measure physical fitness in older adults with intellectual disability (ID) is lacking. As part of the study Healthy Ageing with Intellectual Disabilities with 1,050 older clients with ID in three Dutch care services, the feasibility of 8 physical fitness tests was expressed in completion rates: box and block test, response time test, Berg balance scale, walking speed, grip strength, 30-s chair stand, 10-m incremental shuttle walking test, and the extended modified back saver sit and reach test. All tests had moderate to good feasibility in all subgroups, except for the participants with profound ID (all tests), severe ID (response time test and Berg balance scale), and wheelchair users (all tests that involve the legs). We conclude that the 8 tests are feasible to measure physical fitness in most older adults with ID.
Family Caregivers' Perspectives on Barriers and Facilitators of Cervical and Breast Cancer Screening for Women with Intellectual Disability
Authors: Swaine Jamie G. , Dababnah Sarah , Parish Susan L. , Luken Karen 
Published: January 2013

Abstract
Women with intellectual disability do not receive cervical and breast cancer screening at the same number as women without disabilities. Numerous barriers to receipt of screening have been reported by individuals with intellectual disability, paid caregivers, nurses, and other medical professionals. This study utilized semi-structured qualitative interviews to assess barriers to care from the perspective of female familial caregivers (n  =  32). Caregivers reported a number of barriers to care including not knowing or not believing the exam was needed for their family member and discomfort during exams. Caregivers also described enablers to screening. The most common response to what enabled the woman with an intellectual disability to receive the exam was preparation prior to the exam. A significant portion of the sample of family caregivers lacked knowledge about the need for cervical and breast cancer screening by women with intellectual disability. Policy recommendations are discussed.
Reviews Books
Authors: Flett Tracey , Gates Brendan , Nunoda Erin , Stamm Matthew D.C. 
Published: January 2013

Film and Stereotypes: A Challenge for the Consciousness of Man
Film and Stereotypes: A Challenge for Cinema and Theory, Jorg Schweinitz, Laura Schleussner (trans.), (2011) New York: Columbia University Press, 368pp., ISBN: 9780231151498 (pbk), $27.50 ISBN: 9780231151481 (hbk),
$84.50
Death in Venice: A Queer Film Classic, Will Aitken, (2011) Vancouver: Arsenal Pulp Press, 187pp., ISBN: 9781551524184 (pbk), $14.95
Gender Meets Genre in Postwar Cinemas, Christine Gledhill (ed.), (2012) Champaign: University of Illinois Press, 288pp., ISBN: 9780252078316
(pbk), $30.00
Documentary (Routledge Film Guidebooks), Dave Saunders, (2010) London: Routledge, 274pp., ISBN: 0415473101 (pbk), $28.95, ISBN: 0415473098 (hbk), $105.00, ISBN: 0203852680 (ebk), $28.95
Surfactant Administration via Thin Catheter During Spontaneous Breathing: Randomized Controlled Trial
Authors: Kanmaz H. Gozde , Erdeve Omer , Canpolat F. Emre , Mutlu Banu , Dilmen Ugur 
Published: January 2013

BACKGROUND:
The primary aim of this randomized study was to describe the feasibility of early administration of surfactant via a thin catheter during spontaneous breathing (Take Care) and compare early mechanical ventilation (MV) requirement with the InSurE (Intubate, Surfactant, Extubate) procedure.

METHODS:
Preterm infants, who were &lt;32 weeks and stabilized with nasal continuous positive airway pressure (nCPAP) in the delivery room, were randomized to receive early surfactant treatment either by the Take Care or InSurE technique. Tracheal instillation of 100 mg/kg poractant α via 5-F catheter during spontaneous breathing under nCPAP was performed in the intervention group. In the InSurE procedure, infants were intubated, received positive pressure ventilation for 30 seconds after surfactant instillation, and placed on nCPAP immediately.

RESULTS:
One hundred infants in each group were analyzed. The MV requirement in the first 72 hours of life was significantly lower in the Take Care group when compared with the InSurE group (30% vs 45%, P = .02, odds ratio –0.52, 95% confidence interval –0.94 to –0.29). Mean duration of both nCPAP and MV were significantly shorter in the Take Care group (P values .006 and .002, respectively). Bronchopulmonary dysplasia rate was significantly lower among the infants treated with the Take Care technique (relative risk –0.27, 95% confidence interval –0.1 to –0.72)

CONCLUSIONS:
The Take Care technique is feasible for the treatment of respiratory distress syndrome in infants with very low birth weight. It significantly reduces both the need and duration of MV, and thus the bronchopulmonary dysplasia rate in preterm infants.
Parental Leave for Residents and Pediatric Training Programs
Authors:   SECTION ON MEDICAL STUDENTS, RESIDENTS, AND FELLOWSHIP TRAINEES,   COMMITTEE ON EARLY CHILDHOOD, Fussell Jill J. , Johnson Lara W. , Batlivala Sarosh , Riedmann Natalie , Haischer-Rollo Gayle , Von Oettingen Julia , Tjoeng Yuen Lie , Kelly Erin , Garg Padma , Slovin Sara , Myles David , Becton Lauren , Thattaliyath Bijoy , Hornik Matthew , Reynolds Kimberly , Marks Jessie , Kuehler Maggie , Patel Rupal M. , Lucke Ashley , Patel Neha , Malik Faisal , Van Dyne Elizabeth , Chao Nicole , Marriott Oneka , Diamond Melissa , Matos Renee , Donoghue Elaine , Gleason Mary Margaret , Jones Veronnie F. , Mendelsohn Alan L. , Schulte Elaine E. , Williamson Patricia Gail 
Published: January 2013

This Policy Statement was reaffirmed April 2019.
The American Academy of Pediatrics (AAP) is committed to the development of rational, equitable, and effective parental leave policies that are sensitive to the needs of pediatric residents, families, and developing infants and that enable parents to spend adequate and good-quality time with their young children. It is important for each residency program to have a policy for parental leave that is written, that is accessible to residents, and that clearly delineates program practices regarding parental leave. At a minimum, a parental leave policy for residents and fellows should conform legally with the Family Medical Leave Act as well as with respective state laws and should meet institutional requirements of the Accreditation Council for Graduate Medical Education for accredited programs. Policies should be well formulated and communicated in a culturally sensitive manner. The AAP advocates for extension of benefits consistent with the Family Medical Leave Act to all residents and interns beginning at the time that pediatric residency training begins. The AAP recommends that regardless of gender, residents who become parents should be guaranteed 6 to 8 weeks, at a minimum, of parental leave with pay after the infant’s birth. In addition, in conformance with federal law, the resident should be allowed to extend the leave time when necessary by using paid vacation time or leave without pay. Coparenting, adopting, or fostering of a child should entitle the resident, regardless of gender, to the same amount of paid leave (6–8 weeks) as a person who takes maternity/paternity leave. Flexibility, creativity, and advanced planning are necessary to arrange schedules that optimize resident education and experience, cultivate equity in sharing workloads, and protect pregnant residents from overly strenuous work experiences at critical times of their pregnancies.
Infant Feeding and Transmission of Human Immunodeficiency Virus in the United States
Authors:   COMMITTEE ON PEDIATRIC AIDS, Mofenson Lynne M. , Flynn Patricia M. , Aldrovandi Grace M. , Chadwick Ellen Gould , Chakraborty Rana , Cooper Ellen Rae , Schwarzwald Heidi , Martinez Jaime , Van Dyke Russell B. 
Published: January 2013

This Policy Statement was revised. See https://doi.org/10.1542/peds.2024-066843.
Physicians caring for infants born to women infected with HIV are likely to be involved in providing guidance to HIV-infected mothers on appropriate infant feeding practices. It is critical that physicians are aware of the HIV transmission risk from human milk and the current recommendations for feeding HIV-exposed infants in the United States. Because the only intervention to completely prevent HIV transmission via human milk is not to breastfeed, in the United States, where clean water and affordable replacement feeding are available, the American Academy of Pediatrics recommends that HIV-infected mothers not breastfeed their infants, regardless of maternal viral load and antiretroviral therapy.
Occurrence of CCA-treated timber in caterers’ fuelwood stocks in the Cape Town region
Authors: Niyobuhungiro Rissa , Naidoo Sivapregasen , Dalvie Aqiel , Von Blottnitz Harro 
Published: January 2013

Wood used as fuel under conditions of urban poverty is a source of air pollution. Fuelwood is harvested from peri-urban green areas or sourced as waste from industry or commerce, and used in the informal economy, both by households and by productive activities such as roadside catering. End-of-life timber may have previously been treated for protection, sometimes by impregnation with chromated copper arsenate (CCA). Combustion of CCA-treated timber could magnify the health and environmental risks associated with air pollution, as a result of the release of arsenic and chromium in toxic and carcinogenic forms. Fuelwood supplies of roadside caterers in the urban settlements of Nyanga and Khayelitsha were randomly sampled and 86 collected specimens were prepared for analysis. A further 12 samples were taken, based on their appearance, from households and caterers in settlements near Stellenbosch, Worcester and Paarl. Shavings from the timber specimens were microwave digested using nitric acid and analysed using inductively coupled plasma analysis. All samples collected in the first round showed low concentrations of Cr, Cu and As, believed to be representative of natural backgrounds. Of the 12 peri-urban samples collected in the second round, 8 showed higher levels, typical of treatment to H2–H5 standards. Once it was clear that appearance was a fair indicator of treatment, a further set of 18 suspect pieces from caterers’ supplies in Langa, Nyanga, Khayelitsha and Kayamandi were tested, of which at least 1 sample from each area was found to be treated. CCA-treated timber was found infrequently in fuel supplies of urban caterers, and more frequently in peri-urban areas. Further research and interventions to limit health and environmental risks are recommended.
Affirmation of the Classical Terminology for Experimental Design via a Critique of Casella’sStatistical Design
Authors: Hurlbert Stuart H. 
Published: January 2013

In many disciplines, basic and applied, a high frequency of errors of statistical analysis has been documented in numerous reviews over the decades. One insufficiently appreciated source of this has been the failure of statisticians, individually and collectively, to provide clear definitions for many of the terms they use—and failure to adhere to those definitions across time and across disciplines. The field of experimental design is one area where such problems have become acute. This essay documents that phenomenon via analysis of the terminology used in a recent text in that field,Statistical Designby G. Casella, but the problems identified are widespread and of ancient lineage. There exists a clearer, more consistent terminology, most of it well established more than half a century ago. Key issues are the tripartite structure of the design of an experiment, the need for experimental units to be physically independent of each other, the definition ofpseudoreplication, and confusion about the meaning of split‐unit designs. The problems identified seem to reflect a long‐standing conflict between the classical, experiment‐focused approach to design and the model‐focused approach to the topic. Proponents of the latter have tended to stray from the classical terminology of experimental design, redefining terms in a somewhat casual fashion and thereby considerably confusing non‐statisticians in particular. Wider understanding of these matters should lead to better textbooks, better teaching, and better statistical practice.It is convenient to introduce a standard terminology.–Cox (1958, p. 2)The users of statistics encounter a frustrating problem: statisticians seem inconsistent in the definitions they attach to certain words and in their use of symbols.–Urquhart (1981)Is the subject of statistics to lead to different terminologies in different areas of application? This reviewer suggests not. If this be accepted then the onus is on the latter‐day workers, e.g., in psychology, to read the prior literature and try to follow usage or at the very least, give also the nomenclature that is standard to the statistics profession.–Kempthorne (1982)Conceptual and inferential errors may arise because of vague and imprecise definitions and formulations.–Federer (1993)Unfortunately, the terminology for error reduction designs using the split‐unit principle is not quite uniform.–Hinkelmann and Kempthorne (2008)In conclusion, reform and standardization of terminology in statistics, experimental design and sampling design is badly needed, is possible, and would improve statistical practice.–Hurlbert (2009)