bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual U wave induced by reconstructed retrosternal esophagus
Authors: Yamagata Kenichiro , Uno Kansei , Mori Kazuhiko , Seto Yasuyuki 
Published: October 2015

Key Clinical MessageThe present case shows that a broad compression of the right ventricle by the reconstructed stomach tube after esophagus cancer surgery induced an abnormal U wave. When facing an abnormal ECG, we should keep in mind of the mechanical compression to the heart as a differential diagnosis.
Ligand Noninnocence in Coinage Metal Corroles: A Silver Knife‐Edge
Authors: Thomas Kolle E. , Vazquez‐Lima Hugo , Fang Yuanyuan , Song Yang , Gagnon Kevin J. , Beavers Christine M. , Kadish Karl M. , Ghosh Abhik 
Published: October 2015

AbstractInvited for the cover of this issue are Abhik Ghosh and his collaborators at UiT (The Arctic University of Norway, Tromsø) and in the United States. The image depicts a silver corrole complex poised on the summit ridge of Mount Sir Alexander, a peak of the Canadian Rockies (image courtesy of Chris Goulet), symbolizing the balance between innocent and noninnocent ligands. Read the full text of the article at 10.1002/chem.201502150.
High sensitivity flow cytometry of membrane vesicles
Authors: Stoner Samuel A. , Duggan Erika , Condello Danilo , Guerrero Abraham , Turk James R. , Narayanan Padma K. , Nolan John P. 
Published: October 2015

AbstractExtracellular vesicles (EVs) are attracting attention as vehicles for inter‐cellular signaling that may have value as diagnostic or therapeutic targets. EVs are released by many cell types and by different mechanisms, resulting in phenotypic heterogeneity that makes them a challenge to study. Flow cytometry is a popular tool for characterizing heterogeneous mixtures of particles such as cell types within blood, but the small size of EVs makes them difficult to measure using conventional flow cytometry. To address this limitation, a high sensitivity flow cytometer was constructed and EV measurement approaches that allowed them to enumerate and estimate the size of individual EVs, as well as measure the presence of surface markers to identify phenotypic subsets of EVs. Several fluorescent membrane probes were evaluated and it was found that the voltage sensing dye di‐8‐ANEPPS could produce vesicle fluorescence in proportion to vesicle surface area, allowing for accurate measurements of EV number and size. Fluorescence‐labeled annexin V and anti‐CD61 antibody was used to measure the abundance of these surface markers on EVs in rat plasma. It was shown that treatment of platelet rich plasma with calcium ionophore resulted in an increase in the fraction of annexin V and CD61‐positive EVs. Vesicle flow cytometry using fluorescence‐based detection of EVs has the potential to realize the potential of cell‐derived membrane vesicles as functional biomarkers for a variety of applications. © 2015 International Society for Advancement of Cytometry
Timing synchronization method for pilot‐based coherent detection
Authors: Torres J. , Hernández F. , Hajj Shehadeh Y. El 
Published: October 2015

SummaryCognitive radio systems play an important role in the current digital communication systems. With regard to the methods developed, the importance of a coherent detector with matched filters arises, taking into account the optimal properties verified in detection and sensing time. However, the need of perfect timing limits the applicability of this type of system, because of the complexity in hardware implementation. Based upon slope estimation techniques, the present article addresses new methods for tackling this problem. A low complexity system is obtained, and applications can be considered for finding white space in digital television. The results show a good performance with regard to the probability of detection and robustness regarding frequency offset. Copyright © 2015 John Wiley & Sons, Ltd.
Empathy and Modern Technology: A Neuroergonomics Perspective
Authors: Wachowicz Barbara , Lewandowska Koryna , Popek Anna , Karwowski Waldemar , Marek Tadeusz 
Published: October 2015

AbstractThe primary purpose of this paper is to discuss the role of empathy in the design of advanced systems in manufacturing and service industries in order to ensure suitable working conditions for employees from the social and technological point of view. The origins and components of empathy are briefly reviewed. The neural underpinnings of three components of empathy, including cognitive, emotional, and behavioral aspects, are considered in the context of human–human and human–machine interactions, as well as design of working environments. Finally, the potential advantages of applying empathy‐related knowledge to the design and development of human‐centered technology are discussed.
Laser and electron‐beam powder‐bed additive manufacturing of metallic implants: A review on processes, materials and designs
Authors: Sing Swee Leong , An Jia , Yeong Wai Yee , Wiria Florencia Edith 
Published: October 2015

ABSTRACTAdditive manufacturing (AM), also commonly known as 3D printing, allows the direct fabrication of functional parts with complex shapes from digital models. In this review, the current progress of two AM processes suitable for metallic orthopaedic implant applications, namely selective laser melting (SLM) and electron beam melting (EBM) are presented. Several critical design factors such as the need for data acquisition for patient‐specific design, design dependent porosity for osteo‐inductive implants, surface topology of the implants and design for reduction of stress‐shielding in implants are discussed. Additive manufactured biomaterials such as 316L stainless steel, titanium‐6aluminium‐4vanadium (Ti6Al4V) and cobalt‐chromium (CoCr) are highlighted. Limitations and future potential of such technologies are also explored. © 2015 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 34:369–385, 2016.
Awake examination versus DISE for surgical decision making in patients with OSA: A systematic review
Authors: Certal Victor F. , Pratas Rui , Guimarães Lidia , Lugo Rodolfo , Tsou Yungan , Camacho Macario , Capasso Robson 
Published: October 2015

ObjectiveTraditionally, upper airway examination is performed while the patient is awake. However, in the past two decades, drug‐induced sleep endoscopy (DISE) has been used as a method of tridimensional evaluation of the upper airway during pharmacologically induced sleep. This study aimed to systematically review the evidence regarding the usefulness of DISE compared with that of traditional awake examination for surgical decision making in patients with obstructive sleep apnea (OSA).Data SourcesScopus, PubMed, and Cochrane Library databases were searched.Review MethodsOnly studies with a primary objective of evaluating the usefulness of DISE for surgical decision making in patients with OSA were selected. The included studies directly compared awake examination data with DISE outcome data in terms of possible influences on surgical decision making and operation success.ResultsA total of eight studies with 535 patients were included in this review. Overall, the surgical treatment changed after DISE in 50.24% (standard deviation 8.4) cases. These changes were more frequently associated with structures contributing to hypopharyngeal or laryngeal obstruction. However, these differences do not automatically indicate a higher success rate.ConclusionThis review emphasized the direct impact of DISE compared with that of awake examination on surgical decision making in OSA patients. However, it is also clear that the available published studies lack evidence on the association between this impact and surgical outcomes. Laryngoscope, 126:768–774, 2016
Natural history and management of Fanconi anemia patients with head and neck cancer: A 10‐year follow‐up
Authors: Kutler David I. , Patel Krupa R. , Auerbach Arleen D. , Kennedy Jennifer , Lach Francis P. , Sanborn Erica , Cohen Marc A. , Kuhel William I. , Smogorzewska Agata 
Published: October 2015

Objectives/HypothesisTo describe the management and outcomes of Fanconi anemia (FA) patients with head and neck squamous cell carcinoma.Study DesignCohort study.MethodsDemographic information, prognostic factors, therapeutic management, and survival outcomes for FA patients enrolled in the International Fanconi Anemia Registry who developed head and neck squamous cell carcinoma (HNSCC) were analyzed.ResultsThirty‐five FA patients were diagnosed with HNSCC at a mean age of 32 years. The most common site of primary cancer was the oral cavity (26 of 35, 74%). Thirty patients underwent surgical resection of the cancer. Sixteen patients received radiation therapy with an average radiation dose of 5,050 cGy. The most common toxicities were high‐grade mucositis (9 of 16, 56%), hematologic abnormalities (8 of 16, 50%), and dysphagia (8 of 16, 50%). Three patients received conventional chemotherapy and had significant complications, whereas three patients who received targeted chemotherapy with cetuximab had fewer toxicities. The 5‐year overall survival rate was 39%, with a cause‐specific survival rate of 47%.ConclusionsFanconi anemia patients have a high risk of developing aggressive HNSCC at an early age. Fanconi anemia patients can tolerate complex ablative and reconstructive surgeries, but careful postoperative care is required to reduce morbidity. The treatment of FA‐associated HNSCC is difficult secondary to the poor tolerance of radiation and chemotherapy. However, radiation should be used for high‐risk cancers due to the poor survival in these patients.Level of Evidence4. Laryngoscope, 126:870–879, 2016
Polymerization Mechanism in the Presence of 1,1‐Diphenylethylene Part 2: Synthesis and Characterization of PMA and PSt
Authors: Zhao Minjian , Fu Zhifeng , Shi Yan , Yang Wantai 
Published: October 2015

The polymerization of methyl acrylate and styrene in the presence of 1,1‐diphenylethylene (DPE) is investigated to monitor the impact of different monomers on the structure of DPE‐containing polymers. Poly(methyl acrylate) (PMA) and polystyrene (PSt) with low molecular weight are synthesized and characterized. According to the results of the 1H nuclear magnetic resonance (1H‐NMR) spectroscopy, DPE is incorporated into PMA and PSt polymer chains as diphenyl‐substituted structure. The resulting PMA polymers containing only one DPE unit show good agreement with the mass spectrometry results obtained by electrospray‐ionization quadrupolar time‐of‐flight mass spectrometry. The gel permeation chromatography results of PSt polymers are consistent with the molecular weight obtained by 1H‐NMR, indicating that each PSt polymer chain has only one DPE molecule.
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Characterizing blood–brain barrier perturbations after exposure to human triglyceride‐rich lipoprotein lipolysis products using MRI in a rat model
Authors: Ng Kit Fai , Anderson Steve , Mayo Patrice , Aung Hnin Hnin , Walton Jeffrey H. , Rutledge John C. 
Published: October 2015

PurposePrevious studies indicated hyperlipidemia may be a risk factor for Alzheimer's disease, but the contributions of postprandial triglyceride‐rich lipoprotein (TGRL) are not known. In this study, changes in blood–brain barrier diffusional transport following exposure to human TGRL lipolysis products were studied using MRI in a rat model.MethodsMale Sprague‐Dawley rats (∼180–250 g) received an i.v. injection of lipoprotein lipase (LpL)‐hydrolyzed TGRL (n = 8, plasma concentration ≈ 150 mg human TGRL/dL). Controls received i.v. injection of either saline (n = 6) or LpL only (n = 6). The 1H longitudinal relaxation rate R1 = 1/T1 was measured over 18 min using a rapid‐acquired refocus‐echo (RARE) sequence after each of three injections of the contrast agent Gd‐DTPA. Patlak plots were generated for each pixel yielding blood‐to‐brain transfer coefficients, Ki, chosen for best fit to impermeable, uni‐directional influx or bi‐directional flux models using the F‐test.ResultsAnalysis from a 2‐mm slice, 2‐mm rostral to the bregma showed a 275% increase of mean Ki during the first 20 min after infusion of human TGRL lipolysis product that differed significantly compared with saline and LpL controls. This difference disappeared by 40 min mark.ConclusionThese results suggest human TGRL lipolysis products can lead to a transient increase in rat BBB permeability. Magn Reson Med 76:1246–1251, 2016. © 2015 The Authors. Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
Alemtuzumab, Fludarabine, Low‐Dose TBI, and Double Umbilical Cord Transplant for Primary Graft Failure in a Patient with Recurrent HLH
Authors: Hege Kerry , Quigg Troy , Delgado David 
Published: October 2015

Graft failure occurs at relatively low frequency, but commonly in hemophagocytic lymphohistiocytosis (HLH), especially with umbilical cord blood transplant (UCBT). No standard approaches to management of graft failure exist. We present a challenging case of relapsed HLH following first UCBT with primary graft failure following second UCBT. We report a novel reduced intensity conditioning regimen of alemtuzumab, 4 Gy total body irradiation and fludarabine for salvage of primary graft failure followed by double UCBT. The reported patient successfully engrafted with 100% donor chimerism following salvage UCBT with no occurrence of acute or chronic graft‐versus‐host disease.
A Cytokine‐Based Diagnostic Program in Pediatric Aplastic Anemia and Hypocellular Refractory Cytopenia of Childhood
Authors: Elmahdi Shaimaa , Hama Asahito , Manabe Atsushi , Hasegawa Daisuke , Muramatsu Hideki , Narita Atsushi , Nishio Nobuhiru , Ismael Olfat , Kawashima Nozomu , Okuno Yusuke , Xu Yinyan , Wang Xinan , Takahashi Yoshiyuki , Ito Masafumi , Kojima Seiji 
Published: October 2015

BackgroundDistinguishing hypocellular refractory cytopenia of childhood (RCC) from aplastic anemia (AA) is challenging. Thus far, no studies have compared the cytokine profiles in patients with AA to those with hypocellular RCC. In the present study, we addressed whether thrombopoietin (TPO) and interleukin 17 (IL‐17) plasma levels are useful for differentiating between the two diseases.MethodsWe measured the endogenous plasma concentrations of TPO and IL‐17 in 29 patients with AA, 34 patients with hypocellular RCC, and 31 healthy controls using sensitive enzyme‐linked immunosorbent assays.ResultsThe TPO and IL‐17 plasma levels were significantly lower in patients with hypocellular RCC than in patients with AA (P < 0.001 and P = 0.007, respectively). The multivariate logistic regression analysis identified moderate disease severity, TPO levels of <1,369.8 pg/ml (TPO‐low group, n = 32; odds ratio (OR), 13.40; 95% confidence intervals (CI), 3.001–51.254; P < 0.001), and IL‐17 levels of <22.2 pg/ml (IL‐17‐low group, n = 33; OR, 4.11; 95% CI, 1.033—19.404; P = 0.031) as independent factors discriminating hypocellular RCC from AA. Importantly, 25 (78.1%) of 32 patients in the TPO‐low group and 25 (75.8%) of 33 patients in the IL‐17‐low group were diagnosed as having hypocellular RCC. Moreover, 22 (71%) of 31 patients in the TPO‐high group and 21 (70%) of 30 patients in the IL‐17‐high group were diagnosed as having AA.ConclusionsTPO and IL‐17 levels are useful for differentiating hypocellular RCC from AA. Prospective studies are required to confirm our findings.
A secure, service priority‐based incentive scheme for delay tolerant networks
Authors: Xie Yongming , Zhang Yan 
Published: October 2015

AbstractDelay tolerant networks are resource‐constrained networks, where nodes are required to cooperate with each other to relay messages (bundles) in a store‐carry‐forward fashion. Because of the constrained resources, some selfish nodes are reluctant to relay bundles for other nodes in order to save their own resources. Previous studies focus on one kind of credit‐based incentive schemes in which a source pays credits (virtual coins) to intermediates to compensate for their resources consumption. Although these schemes can restrain selfish behaviors to a certain extent, they may cause an undesirable effect on some honest nodes, especially on boundary nodes and inactive nodes. To mitigate this issue, first we propose a service priority‐based incentive scheme (SIS) where a relaying (viewed as a service) priority, instead of credits, is used as an incentive metric to stimulate nodes to fairly cooperate. In the SIS, a node which relayed more bundles is granted a higher service priority, and it will obtain a higher bundle delivery ratio correspondingly. Then, to deal with the potential attacks against the SIS, we also present three security solutions including the signature chain, cooperation frequency statistics, and combination clearance. We evaluate the proposed scheme on the opportunistic network environment simulator. The extensive results show that the SIS is able to improve the bundle delivery ratio of honest nodes and efficiently inhibits the selfish behaviors in comparison with credit‐based incentive schemes. Copyright © 2015 John Wiley & Sons, Ltd.
A systematic review and meta‐analysis of the epidemiology and burden of venous thromboembolism among pregnant women
Authors: Kourlaba Georgia , Relakis John , Kontodimas Stathis , Holm Majbrit V. , Maniadakis Nikos 
Published: October 2015

AbstractBackgroundPregnancy‐related venous thromboembolism (VTE) is one of the leading causes of maternal morbidity and mortality.ObjectivesTo review the epidemiology, and humanistic and economic burden of pregnancy‐related VTE.Search strategyMedline, the Cochrane Central Register of Controlled Trials, Econlit, Science Direct, JSTOR, Oxford Journals, and Cambridge Journals were searched for reports published between January 2000 and December 2012. Keywords related to VTE, pregnancy, and epidemiology and the humanistic and economic burdens were combined.Selection criteriaEligible studies evaluated the incidence, mortality, recurrence, complications, quality‐of‐life, and economic burden of VTE among pregnant women, and had been published in English.Data collection and analysisBackground information of the study, participants’ characteristics, and study outcomes were collected. Meta‐analyses of data were performed.Main resultsTwenty studies were included, none of which investigated the economic burden. The pooled overall incidence of pregnancy‐related VTE was 1.2 per 1000 deliveries. The pooled VTE case fatality rate was 0.68% and the recurrence rate was 4.27%. The pooled risk of major bleeding was 1.05%. Post‐thrombotic syndrome seemed to have a negative effect on quality of life.ConclusionsAlthough the incidence of VTE was found to be relatively low during pregnancy and the postpartum period, the clinical burden is high. Further research is required to assess the economic burden of pregnancy‐relate VTE.
Osteotomía de acortamiento del hueso grande en la enfermedad de Kienböck asociada a varianza ulnar positiva o neutra
Authors: Hernández J.C. , Pascual M.C. , Gómez J.C. 
Published: October 2015

Objetivos: La enfermedad de Kienböck se asocia generalmente a cubitus minus y la descompresión quirúrgica más común es a nivel radial. El objetivo es conocer los efectos de realizarla en el hueso grande cuando se encuentra asociada a varianza cubital normal o positiva.Material y métodos: Realizamos un estudio retrospectivo de los resultados de la osteotomía de acortamiento del hueso grande en la enfermedad de Kienböck sin cubitus minus. Hemos revisado a 6 pacientes, intervenidos entre 2006 y 2013 en el Hospital Universitario Ramón y Cajal (Madrid). El seguimiento medio fue 36 meses (12-93). Se registraron: escala de valoración del dolor (EVA), rango de movimiento de la muñeca, fuerza de prensión palmary de la pinza, valoración funcional (DASH, Mayo Score), así como estudio radiológico y con RM.Resultados: Se obtuvo una mejoría clínica y funcional de los parámetros estudiados, pero no de los radiológicos. En un caso la enfermedad evolucionó y el resto mantuvo los estadios radiológico (Lichtman) iniciales, consiguiendo la consolidación de la osteotomía en todos los casos. No se apreciaron complicaciones destacables.Conclusión: La osteotomía de acortamiento del hueso grande es una técnica que oferta buenos y duraderos resultados en pacientes con enfermedad de Kienböck sin cubitus minus ni cambios degenerativos carpianos.
Uncovering productive morphosyntax in French-learning toddlers: a multidimensional methodology perspective
Authors: BARRIÈRE ISABELLE , GOYET LOUISE , KRESH SARAH , LEGENDRE GÉRALDINE , NAZZI THIERRY 
Published: October 2015

AbstractThe present study applies a multidimensional methodological approach to the study of the acquisition of morphosyntax. It focuses on evaluating the degree of productivity of an infrequent subject–verb agreement pattern in the early acquisition of French and considers the explanatory role played by factors such as input frequency, semantic transparency of the agreement markers, and perceptual factors in accounting for comprehension of agreement in number (singular vs. plural) in an experimental setting. Results on a pointing task involving pseudo-verbs demonstrate significant comprehension of both singular and plural agreement in children aged 2;6. The experimental results are shown not to reflect input frequency, input marker reliability on its own, or lexically driven knowledge. We conclude that toddlers have knowledge of subject–verb agreement at age 2;6 which is abstract and productive despite its paucity in the input.
Hospital Nurses’ Competencies in Disaster Situations: A Qualitative Study in the South of Brazil
Authors: Marin Sandra M. , Witt Regina R. 
Published: October 2015

AbstractIntroductionHospital nurses play a key role in the aftermath of the occurrence of disasters and need specific competencies to work in these situations. From a global perspective, few models exist that focus on disaster nursing.ProblemThis study aimed to identify hospital nurses’ competencies in disaster situations.MethodA qualitative, descriptive, exploratory study was developed using focus groups as a method of data collection. Three meetings were held from June through September 2012 with nurses who worked at a hospital used as reference for disaster situations in the South of Brazil. Thematic analysis of collected data generated the competencies. For statement standardization, a format consistent with a verb, a noun, and a complement was adopted.ResultsThe group validated 17 competencies, which were organized according to the phases of emergency management described by the World Health Organization (WHO) and classified in domain areas of management, health care, communication, and education.ConclusionsThe competencies identified in this study can contribute to the education and practice of nurses in the hospital ambience, strengthening its capacity to face disaster situations.MarinSM,WittRR.Hospital nurses’ competencies in disaster situations: a qualitative study in the South of Brazil.Prehosp Disaster Med.2015;30(6):548–552.