bluuebunny/crossref_metadata_2025_split huggingface dataset:
A pure invasive cribriform carcinoma of the breast with bone metastasis if untreated for thirteen years: a case report and literature review
Authors: Zhang Wei , Lin Zhichun , Zhang Tongxian , Liu Fen , Niu Yun 
Published: November 2012

AbstractWe report a case of pure invasive cribriform carcinoma of the breast, which had been untreated for thirteen years, being found with bone metastasis at initial presentation, because distant metastasis is rarely found in this tumor. A fifty-nine-year-old postmenopausal woman presented with a large left breast mass. Although she had noticed a lump in a left breast thirteen years ago, she had not sought treatment. The tumor had enlarged gradually since from one year before and become ulcerated. The two enlarged axillary lymph nodes were also palpable. After two cycles of neoadjuvant chemotherapy, she underwent left radial mastectomy with a free skin graft. Emission computed tomography result has confirmed bone metastasis. The histological diagnosis of the tumor revealed the pure invasive cribriform carcinoma, since over than ninety percent of invasive tumor components showed a characteristic cribriform growth, and the remainder was tubular carcinoma. She has been well without evidence of tumor recurrence for seven years after surgery and several routine postoperative therapies. Although with favorable prognosis, pure invasive cribriform carcinoma is still possible to develop into the advanced (Stage four) breast cancer if untreated for a long time. However, the survival of this patient for free disease after several locoregional and systemic therapies maybe provide a supplement for invasive cribriform carcinoma’s excellent prognosis.
Tumorigenesis role and clinical significance of DJ-1, a negative regulator of PTEN, in supraglottic squamous cell carcinoma
Authors: Zhu Xiao-Lin , Wang Zhang-Feng , Lei Wen-Bin , Zhuang Hui-Wen , Hou Wei-Jian , Wen Yi-Hui , Wen Wei-Ping 
Published: November 2012

Abstract

Background
DJ-1 can induce the tumor cell proliferation and invasion via down-regulating PTEN in many malignant tumors, and correlated to prognostic significance. However, the tumorigenesis role and clinical significance of DJ-1 in supraglottic squamous cell carcinoma (SSCC) is unclear. We aimed to evaluate the DJ-1 the relationship between DJ-1 and clinicopathological data including patient survival.

Methods
The expression of DJ-1 and PTEN in SSCCs (52) and adjacent non-cancerous tissues (42) was assessed by immunohistochemistry (IHC), and the relationship between DJ-1 and clinicopathological data was analyzed.

Results
DJ-1 was detected mainly in SSCCs (88.5%) and less frequently in adjacent non-cancerous tissues (21.0%). PTEN expression was detected in 46.2% of SSCCs and in 90.5% of adjacent non-cancerous tissues. DJ-1 expression was linked to nodal status (P = 0.009), a highly significant association of DJ-1 expression with shortened patient overall survival (5-year survival rate 88.0% versus 53.9%; P = 0.007; log rank test) was demonstrated.

Conclusions
Our data suggested that DJ-1 over-expression was linked to nodal status, and might be an independent prognostic marker for patients with SSCC.
Enhancing Service Delivery Through Title X Funding: Findings from California
Authors: de Bocanegra Heike Thiel , Maguire Fran , Hulett Denis , Horsley Kathryn , Puffer Maryjane , Brindis Claire D. 
Published: November 2012

CONTEXTThe federal Title X grant program provides funding for family planning services for low‐income women and men. In California, all clinics receiving Title X funds participate in the state's family planning program, Family PACT, along with other public and private providers. The relative extent to which Title X–funded clinics and other Family PACT providers have incorporated enhancements beyond their core medical services has never been studied.METHODSIn 2010, a survey was sent to public‐ and private‐sector Family PACT clinicians to assess whether funding streams were associated with the availability of special services: extended clinic hours, outreach to vulnerable populations, services for clients not proficient in English and use of advanced clinic‐based technologies. Bivariate and logistic regression analyses controlling for potentially confounding factors were conducted.RESULTSGreater proportions of Title X–funded clinics than of other public and private providers had Spanish‐speaking unlicensed clinical staff (89% vs. 71% and 58%, respectively) and Spanish‐language signs (95% vs. 85% and 82%). Title X–funded providers were more likely than other public providers to offer extended clinic hours, provide outreach to at least three vulnerable or hard‐to‐reach populations, and use three or more advanced technologies (odds ratios, 2.0–2.9).CONCLUSIONSCompared with other Family PACT providers, clinics that receive Title X funding have implemented greater infrastructure enhancements to promote access and improve the quality of service for underserved populations. This may be because Title X–funded providers have more financial opportunities to provide the array of services that best respond to their clients’ needs.
Neurosteroids and GABAergic signaling in health and disease
Authors: MacKenzie Georgina , Maguire Jamie 
Published: November 2012

AbstractEndogenous neurosteroids such as allopregnanolone, allotetrahydrodeoxycorticosterone, and androstanediol are synthesized either de novo in the brain from cholesterol or are generated from the local metabolism of peripherally derived progesterone or corticosterone. Fluctuations in neurosteroid concentrations are important in the regulation of a number of physiological responses including anxiety and stress, reproductive, and sexual behaviors. These effects are mediated in part by the direct binding of neurosteroids to γ-aminobutyric acid type-A receptors (GABAARs), resulting in the potentiation of GABAAR-mediated currents. Extrasynaptic GABAARs containing the δ subunit, which contribute to the tonic conductance, are particularly sensitive to low nanomolar concentrations of neurosteroids and are likely their preferential target. Considering the large charge transfer generated by these persistently open channels, even subtle changes in neurosteroid concentrations can have a major impact on neuronal excitability. Consequently, aberrant levels of neurosteroids have been implicated in numerous disorders, including, but not limited to, anxiety, neurodegenerative diseases, alcohol abuse, epilepsy, and depression. Here we review the modulation of GABAAR by neurosteroids and the consequences for health and disease.
Complexation of Tc(IV) with EDTA at varying ionic strength of NaCl
Authors: Boggs Mark A. , Islam Mohammed , Dong Wenming , Wall Nathalie A. 
Published: November 2012

Abstract
The stability constant for Tc(IV)/EDTA complexes were determined using a solvent extraction technique at varying ionic strength (NaCl) and the specific ion interaction theory model allowed for calculating stability constants at zero ionic strength. The stability constants at zero ionic strength for the formation of the TcOEDTA2− and TcOHEDTA− complexes are 1020.0 ± 0.4 and 1025.3 ± 0.5, respectively. The modeled Tc(IV) solubility was calculated to be 3.9 × 10−7 M at near-neutral pH and in presence of 2.5 mM EDTA, a result found to be in good agreement with published solubility experimental data. Speciation calculations showed that TcOEDTA2− is the predominant species between pH 4 and 7.5 in presence of 0.171 mM EDTA, while TcO(OH)2
0 is predominant in basic solution. These studies show that EDTA has a very strong affinity for complexation with Tc(IV) and can increase the environmental mobility of Tc(IV).
Synthesis, characterization and stability properties of Cl-bearing hydrotalcite-pyroaurite solids
Authors: Rozov K. , Curtius Hilde , Neumann Andreas , Bosbach Dirk. 
Published: November 2012

Abstract
A layered double hydroxides (LDH) hydrotalcite-pyroaurite solid solution series (Mg1−x
Fe(II)
x
)3Al1Cl1·nH2O with variable xFesolid = Fe2+/(Fe2++Mg2+) iron mole fractions were studied in co-precipitation experiments at T = 25, 40, 45, 50, 55 and 60 ºC and pH = 10.00 ± 0.05. The compositions of the solids and reaction solutions were determined using ICP-OES, EDX (Mg, Al, Fe) and TGA techniques (Cl−, OH−, H2O). Powder X-ray diffraction was applied for phase identification and determination of unit-cell parameters a
o = b
o and c
o from Bragg evaluation. Syntheses products containing xFesolid > 0.13 display additional X-ray patterns attributed to the mixture of iron oxides and hydroxides. On the other side, precipitates with 0 ≤ xFesolid ≤ 0.13 show only X-ray reflexes typical for pure LDH compositions. Moreover, in this case unit-cell parameters a
o = b
o as a function of xFesolid follow Vegard's law corroborating the existence of a continuous solid solution series. TGA data demonstrated the temperatures at which interlayer H2O molecules and Cl−-anions are lost, and at which temperatures dehydroxylation of brucite-like layer occurs. Based on detailed analyses of TGA curves it was established that the increase of xFesolid does not result in a visible change of the thermal stability of hydrotalcite-pyroaurite solids. From the chemical analyses of both the solids and the reaction solutions after syntheses, preliminary Gibbs free energies of formation were estimated by using GEMS-PSI code package. Values of Gºf (Hydrotalcite) = −3619.04 ± 15.27 kJ/mol and Gºf(Pyroaurite) = −2703.61 ± 191.93 kJ/mol were found at 298.15 K. A comparison of our estimate with Gºf value −3746.90 ± 11.00 kJ/mol for CO3
2−-bearing hydrotalcite presented in our previous studies, denotes the effect of intercalated anion on the aqueous solubilities of LDH when Cl-containing solids have to be more soluble than CO3
2−-bearing substances. Estimation of the standard molar entropy of the hydrotalcite end-member by applying Helgeson's methods and using results of co-precipitation experiments at variable temperatures let us to conclude that derivation of more precise Sºf values would require calorimetric measurements.
Cerebral Palsy and Neonatal Death in Term Singletons Born Small for Gestational Age
Authors: Stoknes Magne , Andersen Guro L. , Dahlseng Magnus Odin , Skranes Jon , Salvesen Kjell Å. , Irgens Lorentz M. , Kurinczuk Jennifer J. , Vik Torstein 
Published: November 2012

BACKGROUND AND OBJECTIVES:
To investigate the probable timing of events leading to cerebral palsy (CP) in singletons born small for gestational age (SGA) at term, taking neonatal death into consideration.

METHODS:
In this registry-based cohort study, data on 400 488 singletons born during 1996–2003 were abstracted from the Medical Birth and the CP registries of Norway. Among 36 604 SGA children (birth weight &lt;10th percentile), 104 died in the neonatal period and 69 developed CP. Apgar scores at 5 minutes, risk factors, MRI findings, and CP subtypes were used to assess the timing of events leading to CP or neonatal death.

RESULTS:
Intrapartum origin of CP was considered in 5 SGA children (7%; 95% confidence interval: 3–16) in comparison with 31 of 263 (12%; 95% confidence interval: 8–16) non-SGA children (P = .28). The proportions of children who died in the neonatal period after a probable intrapartum event did not differ between the groups when children with congenital malformations were excluded. Probable antenatal events leading to CP and neonatal death were more common among SGA than non-SGA children (P &lt; .001).

CONCLUSIONS:
In ∼90% of children born SGA the event leading to CP is of probable antenatal origin. The low proportion of SGA children with CP after a probable intrapartum event was not outweighed by a higher neonatal mortality rate when congenital malformations were excluded. The higher risk of CP among SGA than among non-SGA children is probably due to a higher prevalence of antenatal risk factors.
Observational Studies in the Era of Randomized Trials
Authors: Castillo Renan C. , Scharfstein Daniel O. , MacKenzie Ellen J. 
Published: November 2012

Abstract:
Randomized controlled trials (RCTs) constitute the gold standard for the generation of evidence-based medicine, but may not always be feasible. Furthermore, randomization alone does not guarantee the utility of the research, as evidenced by thousands of uninformative RCTs documented in the literature. Observational studies, including longitudinal, retrospective, and case-control designs, can contribute to the body of evidence in meaningful ways, provide useful information when an RCT is unethical or not feasible, generate hypotheses for RCTs, or provide preliminary work to better inform design of future RCTs. They can also be used to study rare outcomes, risk factors, and side effects, and to examine whether results from RCTs translate into effective treatment in routine practice. Use of modern statistical techniques, both in the study design and in the analysis stage, can improve the usefulness of the evidence obtained from observational studies.
On the Prevention and Analysis of Missing Data in Randomized Clinical Trials: The State of the Art
Authors: Scharfstein Daniel O. , Hogan Joseph , Herman Amir 
Published: November 2012

Abstract:
We summarize and elaborate on the recently published National Research Council report entitled “The Prevention and Treatment of Missing Data in Clinical Trials.” We tailor our discussion to orthopaedic trials. In particular, we discuss the intent-to-treat principle, review study design and prevention ideas to minimize missing data, and present state-of-the-art sensitivity analysis methods for analyzing and reporting the results of studies with missing data.
Standardizing the Evolution of the Postoperative Bariatric Diet
Authors: Isom Kellene A. 
Published: November 2012

In Brief
This article reviews the history of the postoperative nutrition recommendations for today's common bariatric (weight loss) surgery procedures. Discussion of the evolution of postoperative nutrition guidelines supports the proposal for a standardized postoperative diet for patients who undergo a Roux-en-Y gastric bypass or a laparoscopic adjustable gastric band procedure.
John 21:24-25: A case of failed attestation?
Authors: Tolmie D.F. 
Published: November 2012

John 21:24-25: A case of failed attestation In this article the tendency to interpret John 21:24-25 narratologically as a highly sophisticated and effective technique is disputed. Instead it is argued that the Beloved Disciple is identified in these verses as the real author of the Gospel and that the dominating function in John 21 :24-25 is the testimonial function (also known as the function of attestation). It is also argued that the intended effect of this junction is undermined by the awkward manner in which it is fulfilled.
Meta-teoretiese perspektiewe op die waarde van kommunikasie en breinfunksie in die proses van prediking
Authors: Nagel C J , De Klerk B J 
Published: November 2012

The intended object of this article is to undertake an investigation in connection with the importance of creative preaching from a meta-theoretical perspective on the value of communication and brain function. The important role and value of communication is discussed from the viewpoint of communication studies as well as psychology. It is ascertained that interactive communication is very suitable for preaching due to the dynamic interaction that takes place between the sender (God/preacher) and receiver (preacher/congregation) and thus facilitates dialogue between partners of conversation. Further, five basic elements of style, beneficial for the advancement of effective and creative communication, were identified, namely: clarity, interest, evocative language, energy and emotion. The ability to use the whole brain stimulates creativity and the application of the four phases of the process of creativity can successfully be applied in sermon preparation.
Understanding ‘sin’ in the Johannine epistles
Authors: Van der Merwe D J 
Published: November 2012

The author of the Johannine Epistles has a good deal to say about sin. He abhors sin, seeing it as incompatible with God’ s character (oJ qeo;" fw`" ejstin, 1:5; [oJ qeo;"] divkaiov" ejstin, 2:29; and oJ qeo;" ajgavph ejstivn, 4:8) and with the status of believers as God’ s children. In this article attention is given to the following relevant aspects for understanding ‘hamartiology’ in the Johannine epistles from a ‘family perspective’: (1) the ‘family of God’ metaphor is used as the setting in which the author describes his symbolic narrative; (2) a differentiation is made between sin inside and sin outside the family; (3) sin outside the family is also described in terms of reciprocals to emphasize its condemnation; (4) finally, he focuses on the ‘forgiveness of sin’. This investigation is done against the socio-religious circumstances of the Johannine community in order to understand the Elder’ s ethical and doctrinal definitions of sin.
Theological-mythological viewpoints on divine sonship in Genesis 6 and Psalm 2
Authors: Usue E O 
Published: November 2012

This article describes theological and mythological scholarly viewpoints concerning the motif of divine sonship in Genesis 6:1-9 and Psalm 2:1-12. The author , admitting the complex and problematic nature of the inquiry, discusses some of the popular interpretations of both texts and attempts to discern the pros and cons of each reading. Ultimately he points out certain similarities and differences between the two texts. He contends that the motif of divine sonship in Genesis 6 differs in a certain sense from that of Psalm 2. One of the reasons for this difference is that the eschatological expectation of the reign of the Son of God seems to lie behind the text of Psalm 2, whereas, in Genesis 6, it does not.
Human dignity and sexual behavious – A theological perspective
Authors: Vorster N 
Published: November 2012

This article compares the sex ethic of Scripture with the anthropological values that underlie modern sexual morality and gives guidelines for a responsible sex ethics that can safeguard human dignity. As point of departure it states that the biblical view of sexuality must be understood from the perspective of creation and re-creation and not the fall. The creation narratives teach that humanity possesses qualities of sameness and difference that constitutes our being. Sexuality forms the dynamic which bonds the dialectic of sameness and difference into a unity of persons. The article concludes that the African concept of gender , the radical freedom concept of secular society, the utilitarian view of sex, and the postmodern view that sexual behaviour and marriage are social constructs, aggravate sexual promiscuity. In order to fight HIV/AIDS and preserve human dignity the exclusiveness of the sex act, the importance of faithfulness and the sanctity of marriage must be proclaimed.
‘n Christosentriese koinonia-dinamiek agter Paulus se hantering van sekere problematiek in 1 Korintiërs
Authors: De Wet B W 
Published: November 2012

This article reasons that Paul tends to use a Christosentric koinonia-dynamic as a paradigm for addressing some of the problems in 1 Corinthians. As a test case the problem of the eating of food (especially meat), consecrated and/or sacrificed to the idols during social, as well as cultic occasions, as formulated in 8:1a was chosen. Being part of the macro structure of 8:1-11:1 it becomes clear, especially from 10:14-22 that Paul uses especially the dynamic of a Christosentric koinonia paradigm to address this problem. Focusing on the intensity of koinonia, as it functioned within the holy communion and the sacrificial meal of the Israelites, Paul motivates the Corinthians not to have anything to do with sacrificial heathen meals.
Four recent books on spirituality and the Psalms: some contextualising, analytical and evaluative remarks
Authors: Lombaard CJS 
Published: November 2012

In the four years from 2002 to 2005, four new books on the Psalms and spirituality have been published. These are: • Stuhlmueller, C 2002. The spirituality of the Psalms. Collegeville, Minnesota: Liturgical Press. • Brueggemann, W 2002. Spirituality of the Psalms. Minneapolis: Fortress Press. • Waaijman, K 2004. Mystiek in de psalmen. Baarn: Uitgeverij Ten Have. • Firth, D G 2005. Hear , o Lord. A spirituality of the Psalms. Calver: Cliff College Publishing. In this paper, brief remarks on the context within which this publication trend takes place, are made. Each of the works is then briefly described, and general evaluative remarks are concluded with.
In defence of partisan justice - an ethical reflection on “the preferential option for the poor”
Authors: Naude PJ 
Published: November 2012

Can one defend a form of partisan justice? This question is answered in the affirmative in the light of two broad arguments: The theological argument arises from the preferential option for the poor from Latin America, and the philosophical argument is derived from John Rawls’ notion of the least advantaged representative person and assistance due to burdened societies in a global context. In closing, a number of important implications of such a partisan notion of both distributive and cultural justice are explicated. This article is developed in three sections. The first section briefly sketches a profile of the different theological arguments underlying a preferential option for the poor as particularly developed by Latin American liberation theologians, and later accepted in wider ecumenical circles. In the second section, philosophical arguments for a position of “prioritarianism” which seems to support such “preferential option” are outlined. This is attempted via a discussion of two influential books by well-known American political philosopher , John Rawls, namely his A theory of justice (1973), and The law of peoples (1999). Section three concludes the article by demonstrating the synergy between these theological and philosophical views, and by pointing out – in a provisional manner - the important consequences of such a “preferential” or “partisan” view for guiding ethical reflection on local and global socio-economic relations.
Shaping eschatology within science and theology
Authors: Pretorius M 
Published: November 2012

Traditionally, questions about the reign of God, death and resurrection, God’ s judgment and eternal life, have belonged to eschatology, specifically as presented by Biblical scholars. At times, when eschatology has become a topic of debate, it has unfortunately, resulted in accusations and acrimony among scholars. Yet, the Bible is clear about what the end entails; whether that is towards the believer or non-believer. Furthermore, the relationship of theology and science on eschatology has hardly been a topic of discussion. However, in recent times, there have been serious attempts by modern scholars to find common ground between these two seemingly diverse disciplines when it comes to eschatology.
Echt gebeurd? Verhalen of feiten? Over historische en literaire bijbelkritiek en de zeggenschap van de bijbel
Authors: Vroom HM 
Published: November 2012

A serious objection against Christian faith is that the Bible is not trustworthy because the history it relates does not correspond to the facts of history. In theology this problem is “solved” by some biblical scholars by an acceptance of the research methods that are used for all literature alike while others accept the historical critique by understanding the biblical history as a faithful but a-historical revelation. Fundamentalists reject the historical-critical objections and stress the inerrancy of Scripture. In this contribution these three “answers” are rejected: biblical studies shall take the (real) facts serious indeed (pace inerrancy), nor jump into an a-historical revelatory history next to historical criticism (pace strong Barthian views in the “Amsterdam School”), but neither read religious scriptures all in the same way “as all literature” — but apply academic methods as is appropriate for the Hebrew and Greek Bible.