bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tracing Sediment‐Affected Water Masses From Coastal Areas to Offshore Oceans Using In Situ Sensing of Fluorescent Organic Matter
Authors: Yamashita Youhei , Takekuma Toshiyuki , Tajiri Makoto , Oida Joji , Kakehi Shigeho , Ooki Atsushi , Hirawake Toru 
Published: June 2024

AbstractThe lateral transport of nutrient‐rich water masses from coastal areas to offshore areas is an important factor controlling the primary production of phytoplankton in offshore regions. If the coastal low‐salinity waters have high nutrient levels, lateral transport can be traced via salinity observations. However, if high level of nutrients in the waters are not coupled with low salinity, for example, input from coastal sediments, water transport cannot be traced via salinity observations. In this study, visible fluorescent organic matter (FOMvis) was monitored by an in situ sensor as a tracer for sediment‐affected water masses from coastal areas. The FOMvis distribution in the upper 500 m water layer in offshore Japan along the 143°E transect was generally controlled by the distributions of subtropical water (i.e., Kuroshio water and Tsugaru warm current water) and subarctic water (i.e., Oyashio water). However, anomalously high levels of FOMvis were observed at depths of 20–60 m at an observational station, which could not be explained by physical mixing. This likely originated from the lateral transport of water masses from coastal areas. In and around Sendai Bay, where observations were carried out as an example of the Japanese coast, high levels of FOMvis were observed, accompanied by negative N*, an indicator of denitrification, and phosphate and silicic acid inputs from anoxic sediments. These observational results imply that FOMvis observation via in situ sensors can be useful for tracing the input of nutrient‐rich sediment‐affected water masses from coastal areas to offshore oceans.
Improvements of the Microwave Gaseous Absorption Scheme Based on Statistical Regression and Its Application to ARMS
Authors: Kan Wanlin , Shi Yi‐Ning , Yang Jun , Han Yang , Hu Hao , Weng Fuzhong 
Published: June 2024

AbstractAn improved microwave gaseous absorption scheme based on statistical regression is proposed in this study. In the new scheme, Monochromatic Radiative Transfer Model (MonoRTM) replaces the Millimeter‐wave Propagation Model (MPM) to train the new scheme and the effect of real Spectral Response Functions is included in the training process. After the replacement, results of the new scheme are closer to observations from Advanced Technology Microwave Sounder (ATMS) onboard Suomi National Polar‐orbiting Partnership satellite in low level channels while MPM has some advantages in upper level channels. Introducing ozone absorption can cause a systematic bias but results in small standard deviations in channels with frequency 183 ± 1.8 GHz and 183 ± 1 GHz. In addition, the new scheme updates the vertical interpolation of water vapor and optimizes the vertical distribution of Planck function. These updates can reduce biases caused by vertical interpolation, especially for water vapor absorption channels. The bias associated to vertical interpolation can reach 0.25 K whereas the new scheme can decrease it to 0.003 K. To further validate the accuracy of the new scheme, we apply the new scheme to Advanced Radiative transfer Modeling System and compare simulated results to RTTOV 13.2 under 37 and 137 level (L) atmosphere (atm). Observations from ATMS onboard NOAA‐20 are used as true values. Results show that the new scheme agrees with RTTOV 13.2 well in accuracy and performs even better in upper level channels and water vapor absorption channels.
Deep Learning Improves GFS Sea Surface Wind Field Forecast Accuracy in the Northwest Pacific Ocean
Authors: Fu Shu , Huang Wenyu , Luo Jingjia , Liu Dongqing , Sun Danyi , Fu Haohuan , Luo Yong , Wang Bin 
Published: June 2024

AbstractSea surface winds influence shipping, fisheries, and coastal projects. However, the current sea surface wind forecast exhibits noticeable biases. This study introduces a deep learning (DL)‐based bias correction model, WindNet, to improve the Global Forecast System (GFS) sea surface wind field forecast in the Northwest Pacific Ocean (NWPO). WindNet reduces the Root Mean Squared Errors (RMSEs) of wind speed at lead times of 24, 48, and 72 hr from 1.41–1.95 to 1.11–1.55 m s−1, achieving percentage reductions of 20.51%–21.28%. Simultaneously, the RMSEs of wind direction are reduced from 29.67–41.45° to 25.38–36.81°, demonstrating percentage reductions of 11.19%–14.46%. During typhoon passages, the RMSEs of wind speed and direction at three forecast lead times after using WindNet are reduced from 1.57–2.42 to 1.24–1.95 m s−1 and from 30.31–42.35° to 25.88–37.64°, demonstrating percentage reductions of 19.42%–21.02% and 11.12%–14.62%. By integrating a Squeeze‐and‐Excitation Network into WindNet, we find that utilizing information from the circulation field, apart from the zonal and meridional wind components at 10 m height, is crucial for the correction of the sea surface wind speed. WindNet can effectively capture the non‐linear relationship between other low‐level‐circulation‐related variables and sea surface wind speed. Therefore, WindNet remarkably enhances sea surface wind field forecast accuracy in NWPO.
Impact of baseline adipose tissue characteristics on change in adipose tissue volume during a low calorie diet in people with obesity—results from the LION study
Authors: Junker Daniela , Wu Mingming , Reik Anna , Raspe Johannes , Rupp Selina , Han Jessie , Näbauer Stella M. , Wiechert Meike , Somasundaram Arun , Burian Egon , Waschulzik Birgit , Makowski Marcus R. , Hauner Hans , Holzapfel Christina , Karampinos Dimitrios C. 
Published: June 2024

Abstract
Background/Objectives
Weight loss outcomes vary individually. Magnetic resonance imaging (MRI)-based evaluation of adipose tissue (AT) might help to identify AT characteristics that predict AT loss. This study aimed to assess the impact of an 8-week low-calorie diet (LCD) on different AT depots and to identify predictors of short-term AT loss using MRI in adults with obesity.

Methods
Eighty-one adults with obesity (mean BMI 34.08 ± 2.75 kg/m², mean age 46.3 ± 10.97 years, 49 females) prospectively underwent baseline MRI (liver dome to femoral head) and anthropometric measurements (BMI, waist-to-hip-ratio, body fat), followed by a post-LCD-examination. Visceral and subcutaneous AT (VAT and SAT) volumes and AT fat fraction were extracted from the MRI data. Apparent lipid volumes based on MRI were calculated as approximation for the lipid contained in the AT. SAT and VAT volumes were subdivided into equidistant thirds along the craniocaudal axis and normalized by length of the segmentation. T-tests compared baseline and follow-up measurements and sex differences. Effect sizes on subdivided AT volumes were compared. Spearman Rank correlation explored associations between baseline parameters and AT loss. Multiple regression analysis identified baseline predictors for AT loss.

Results
Following the LCD, participants exhibited significant weight loss (11.61 ± 3.07 kg, p < 0.01) and reductions in all MRI-based AT parameters (p < 0.01). Absolute SAT loss exceeded VAT loss, while relative apparent lipid loss was higher in VAT (both p < 0.01). The lower abdominopelvic third showed the most significant SAT and VAT reduction. The predictor of most AT and apparent lipid losses was the normalized baseline SAT volume in the lower abdominopelvic third, with smaller volumes favoring greater AT loss (p < 0.01 for SAT and VAT loss and SAT apparent lipid volume loss).

Conclusions
The LCD primarily reduces lower abdominopelvic SAT and VAT. Furthermore, lower abdominopelvic SAT volume was detected as a potential predictor for short-term AT loss in persons with obesity.
Discrimination and hypertension among a diverse sample of racial and sexual minority men living with HIV: baseline findings of a longitudinal cohort study
Authors: Gillespie Avrum , Song Rui , Barile John P. , Okada Lorie , Brown Shari , Traub Kerry , Trout Julia , Simoncini Gina M. , Hall Casey D. Xavier , Tan Yin , Gadegbeku Crystal A. , Ma Grace X. , Wong Frank Y. 
Published: June 2024

AbstractRacial and sexual orientation discrimination may exacerbate the double epidemic of hypertension (HTN) and HIV that affects men of color who have sex with men (MSM). This was a cross-sectional analysis of African American, Asian American, Native Hawaiian, or Pacific Islander (NHPI) MSM living with HIV (PLWH) cohort in Honolulu and Philadelphia. Racial and sexual orientation discrimination, stress, anxiety, and depression were measured with computer-assisted self-interview questionnaires (CASI). We examined the associations between racial and sexual orientation discrimination with hypertension measured both in the office and by 24-h ambulatory blood pressure monitoring (ABPM) using multivariable logistic regression. Sixty participants (60% African American, 18% Asian, and 22% NHPI) completed CASIs and 24-h ABPM. African American participants (80%) reported a higher rate of daily racial discrimination than Asian American (36%) and NHPI participants (17%, p < 0.001). Many participants (51%) reported daily sexual orientation discrimination. Sixty-six percent of participants had HTN by office measurement and 59% had HTN by 24-h ABPM measurement. Participants who experienced racial discrimination had greater odds of having office-measured HTN than those who did not, even after adjustment (Odds Ratio 5.0 (95% Confidence Interval [1.2–20.8], p = 0.03)). This association was not seen with 24-h ABPM. Hypertension was not associated with sexual orientation discrimination. In this cohort, MSM of color PLWH experience significant amounts of discrimination and HTN. Those who experienced racial discrimination had higher in-office blood pressure. This difference was not observed in 24-h APBM and future research is necessary to examine the long-term cardiovascular effects.
Social context and drug cues modulate inhibitory control in cocaine addiction: involvement of the STN evidenced through functional MRI
Authors: Terenzi Damiano , Simon Nicolas , Gachomba Michael Joe Munyua , de Peretti Jeanne-Laure , Nazarian Bruno , Sein Julien , Anton Jean-Luc , Grandjean Didier , Baunez Christelle , Chaminade Thierry 
Published: June 2024

AbstractAddictions often develop in a social context, although the influence of social factors did not receive much attention in the neuroscience of addiction. Recent animal studies suggest that peer presence can reduce cocaine intake, an influence potentially mediated, among others, by the subthalamic nucleus (STN). However, there is to date no neurobiological study investigating this mediation in humans. This study investigated the impact of social context and drug cues on brain correlates of inhibitory control in individuals with and without cocaine use disorder (CUD) using functional Magnetic Resonance Imaging (fMRI). Seventeen CUD participants and 17 healthy controls (HC) performed a novel fMRI “Social” Stop-Signal Task (SSST) in the presence or absence of an observer while being exposed to cocaine-related (vs. neutral) cues eliciting craving in drug users. The results showed that CUD participants, while slower at stopping with neutral cues, recovered control level stopping abilities with cocaine cues, while HC did not show any difference. During inhibition (Stop Correct vs Stop Incorrect), activity in the right STN, right inferior frontal gyrus (IFG), and bilateral orbitofrontal cortex (OFC) varied according to the type of cue. Notably, the presence of an observer reversed this effect in most areas for CUD participants. These findings highlight the impact of social context and drug cues on inhibitory control in CUD and the mediation of these effects by the right STN and bilateral OFC, emphasizing the importance of considering the social context in addiction research. They also comfort the STN as a potential addiction treatment target.
ChatGPT can help guide and empower patients after prostate cancer diagnosis
Authors: Collin Harry , Keogh Kandice , Basto Marnique , Loeb Stacy , Roberts Matthew J. 
Published: June 2024

Abstract
Background/Objectives
Patients often face uncertainty about what they should know after prostate cancer diagnosis. Web-based information is common but is at risk of being of poor quality or readability.

Subjects/Methods
We used ChatGPT, a freely available Artificial intelligence (AI) platform, to generate enquiries about prostate cancer that a newly diagnosed patient might ask and compared to Google search trends. Then, we evaluated ChatGPT responses to these questions for clinical appropriateness and quality using standardised tools.

Results
ChatGPT generates broad and representative questions, and provides understandable, clinically sound advice.

Conclusions
AI can guide and empower patients after prostate cancer diagnosis through education. However, the limitations of the ChatGPT language-model must not be ignored and require further evaluation and optimisation in the healthcare field.
FRMD6 determines the cell fate towards senescence: involvement of the Hippo-YAP-CCN3 axis
Authors: Park Jung-Jin , Lee Su Jin , Baek Minwoo , Lee Ok-Jun , Nam Seungyoon , Kim Jaehong , Kim Jin Young , Shin Eun-Young , Kim Eung-Gook 
Published: June 2024

AbstractCellular senescence, a hallmark of aging, is pathogenically linked to the development of aging-related diseases. This study demonstrates that FRMD6, an upstream component of the Hippo/YAP signaling cascade, is a key regulator of senescence. Proteomic analysis revealed that FRMD6 is upregulated in senescent IMR90 fibroblasts under various senescence-inducing conditions. Silencing FRMD6 mitigated the senescence of IMR90 cells, suggesting its requirement in senescence. Conversely, the overexpression of FRMD6 alone induced senescence in cells and in lung tissue, establishing a causal link. The elevated FRMD6 levels correlated well with increased levels of the inhibitory phosphorylated YAP/TAZ. We identified cellular communication network factor 3 (CCN3), a key component of the senescence-associated secretory phenotype regulated by YAP, whose administration attenuated FRMD6-induced senescence in a dose-dependent manner. Mechanistically, FRMD6 interacted with and activated MST kinase, which led to YAP/TAZ inactivation. The expression of FRMD6 was regulated by the p53 and SMAD transcription factors in senescent cells. Accordingly, the expression of FRMD6 was upregulated by TGF-β treatment that activates those transcription factors. In TGF-β-treated IMR90 cells, FRMD6 mainly segregated with p21, a senescence marker, but rarely segregated with α-SMA, a myofibroblast marker, which suggests that FRMD6 has a role in directing cells towards senescence. Similarly, in TGF-β-enriched environments, such as fibroblastic foci (FF) from patients with idiopathic pulmonary fibrosis, FRMD6 co-localized with p16 in FF lining cells, while it was rarely detected in α-SMA-positive myofibroblasts that are abundant in FF. In sum, this study identifies FRMD6 as a novel regulator of senescence and elucidates the contribution of the FRMD6-Hippo/YAP-CCN3 axis to senescence.
Observations of diapycnal upwelling within a sloping submarine canyon
Authors: Wynne-Cattanach Bethan L. , Couto Nicole , Drake Henri F. , Ferrari Raffaele , Le Boyer Arnaud , Mercier Herlé , Messias Marie-José , Ruan Xiaozhou , Spingys Carl P. , van Haren Hans , Voet Gunnar , Polzin Kurt , Naveira Garabato Alberto C. , Alford Matthew H. 
Published: June 2024

AbstractSmall-scale turbulent mixing drives the upwelling of deep water masses in the abyssal ocean as part of the global overturning circulation1. However, the processes leading to mixing and the pathways through which this upwelling occurs remain insufficiently understood. Recent observational and theoretical work2–5 has suggested that deep-water upwelling may occur along the ocean’s sloping seafloor; however, evidence has, so far, been indirect. Here we show vigorous near-bottom upwelling across isopycnals at a rate of the order of 100 metres per day, coupled with adiabatic exchange of near-boundary and interior fluid. These observations were made using a dye released close to the seafloor within a sloping submarine canyon, and they provide direct evidence of strong, bottom-focused diapycnal upwelling in the deep ocean. This supports previous suggestions that mixing at topographic features, such as canyons, leads to globally significant upwelling3,6–8. The upwelling rates observed were approximately 10,000 times higher than the global average value required for approximately 30 × 106 m3 s−1 of net upwelling globally9.
Molecular basis for transposase activation by a dedicated AAA+ ATPase
Authors: de la Gándara Álvaro , Spínola-Amilibia Mercedes , Araújo-Bazán Lidia , Núñez-Ramírez Rafael , Berger James M. , Arias-Palomo Ernesto 
Published: June 2024

AbstractTransposases drive chromosomal rearrangements and the dissemination of drug-resistance genes and toxins1–3. Although some transposases act alone, many rely on dedicated AAA+ ATPase subunits that regulate site selectivity and catalytic function through poorly understood mechanisms. Using IS21 as a model transposase system, we show how an ATPase regulator uses nucleotide-controlled assembly and DNA deformation to enable structure-based site selectivity, transposase recruitment, and activation and integration. Solution and cryogenic electron microscopy studies show that the IstB ATPase self-assembles into an autoinhibited pentamer of dimers that tightly curves target DNA into a half-coil. Two of these decamers dimerize, which stabilizes the target nucleic acid into a kinked S-shaped configuration that engages the IstA transposase at the interface between the two IstB oligomers to form an approximately 1 MDa transpososome complex. Specific interactions stimulate regulator ATPase activity and trigger a large conformational change on the transposase that positions the catalytic site to perform DNA strand transfer. These studies help explain how AAA+ ATPase regulators—which are used by classical transposition systems such as Tn7, Mu and CRISPR-associated elements—can remodel their substrate DNA and cognate transposases to promote function.
An intermediate Rb–E2F activity state safeguards proliferation commitment
Authors: Konagaya Yumi , Rosenthal David , Ratnayeke Nalin , Fan Yilin , Meyer Tobias 
Published: June 2024

AbstractTissue repair, immune defence and cancer progression rely on a vital cellular decision between quiescence and proliferation1,2. Mammalian cells proliferate by triggering a positive feedback mechanism3,4. The transcription factor E2F activates cyclin-dependent kinase 2 (CDK2), which in turn phosphorylates and inactivates the E2F inhibitor protein retinoblastoma (Rb). This action further increases E2F activity to express genes needed for proliferation. Given that positive feedback can inadvertently amplify small signals, understanding how cells keep this positive feedback in check remains a puzzle. Here we measured E2F and CDK2 signal changes in single cells and found that the positive feedback mechanism engages only late in G1 phase. Cells spend variable and often extended times in a reversible state of intermediate E2F activity before committing to proliferate. This intermediate E2F activity is proportional to the amount of phosphorylation of a conserved T373 residue in Rb that is mediated by CDK2 or CDK4/CDK6. Such T373-phosphorylated Rb remains bound on chromatin but dissociates from it once Rb is hyperphosphorylated at many sites, which fully activates E2F. The preferential initial phosphorylation of T373 can be explained by its relatively slower rate of dephosphorylation. Together, our study identifies a primed state of intermediate E2F activation whereby cells sense external and internal signals and decide whether to reverse and exit to quiescence or trigger the positive feedback mechanism that initiates cell proliferation.
Automated generation of consistent annual maximum NDVI on coal bases with a new algorithm
Authors: Li Jun , Qin Tingting , Zhang Chengye , Zhang Yicong , Zhang Yaping , Shi Haitao , Yang Yihao 
Published: June 2024

AbstractCoal is one of the most important fossil energy sources and is ensuring global energy security. Annual maximum NDVI (Normalized Difference Vegetation Index) data is an important indicator for the research in balancing coal mining and vegetation conservation. However, the existing annual maximum NDVI data displayed lower values with temporally inconsistent and a noticeable mosaic line. Here we propose an algorithm for automatically generating the annual maximum NDVI of China’s coal bases in Google Earth Engine called: Auto-NDVIcb. The accuracy of the Auto-NDVIcbalgorithm has been verified with an average RMSE of 0.087 for the 14 coal bases from 2013 to 2022. Based on the proposed Auto-NDVIcbalgorithm, an annual maximum NDVI dataset for all 14 coal bases in China from 2013 to 2022 was publicly released. This dataset can be fast and automatically updated online. Hence, the public dataset will continuously serve to monitor the vegetation change induced by coal mining, exploring the mechanism of vegetation degradation, and providing scientific data for developing vegetation protection policies in coal mines.
Nebivolol ameliorates sepsis-evoked kidney dysfunction by targeting oxidative stress and TGF-β/Smad/p53 pathway
Authors: Sabra Rahma Tharwat , Bekhit Amany Abdlrehim , Sabra Nourhan Tharwat , Abd El-Moeze Nadia Ahmed , Fathy Moustafa 
Published: June 2024

AbstractSepsis is a potential fetal organ destruction brought on through an overzealous immunologic reaction to infection, causing severe inflammation, septic shock, and damage to different organs. Although there has been progress in the identification and controlling of clinical sepsis, the fatality rates are still significant. This study, for the first time, intended to examine the possible ameliorative impact of Nebivolol, a β1-adrenergic antagonist antihypertensive drug, against nephrotoxicity resulted from cecal ligation and puncture (CLP)-induced sepsis in rats, on molecular basis. Sixty male Wistar albino rats were chosen. Oxidative stress indicators and biochemical markers of kidney activity were evaluated. Inflammatory mediators, fibrosis- and apoptosis-related proteins and gene expressions were investigated. Moreover, renal histopathological investigation was performed. CLP-induced nephrotoxicity characterized by markedly elevated serum levels of creatinine, blood urea nitrogen, uric acid, and renal malondialdhyde. On the other hand, it decreased serum total protein level, renal superoxide dismutase activity and reduced glutathione level. Additionally, it significantly elevated the renal inflammatory mediators (tumor necrosis factor-alpha, ilnerlukin (IL)-6, and IL-1β) and Caspase-3 protein, reduced IL-10 level, amplified the expression of transforming growth factor-beta 1 (TGF-β1), p-Smad2/3 and alpha-smooth-muscle actin proteins, downregulated the B cell lymphoma-2 (Bcl-2) gene and elevated the transcription of Bcl-2-associated X-protein (Bax), p53 and Nuclear factor-kappa B (NF-κB) genes. Furtheremor, kidney tissues exhibited significant histopathological changes with CLP. On the contrary, Nebivolol significantly improved all these biochemical changes and enhanced the histopathological alterations obtained by CLP. This research showed, for the first time, that Nebivolol effectively mitigated the CLP-induced kidney dysfunction via its antioxidant, antifibrotic and anti-apoptotic activity through modulation of oxidative stress, TGF-β/NF-κB and TGF-β/Smad/p53 signaling pathways.