bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐inflammatory and pro‐healing effects of acetate chitosan sponge with calcium cross‐links
Authors: Chang Liu , Shengdong Wang , Huien Zhang , Liping Liu 
Published: July 2024

AbstractChitosan, a potential material for tissue wound repair, exhibits limitations like poor solubility and low gel strength. Acetate chitosan (CA) was synthesized through ethanol precipitation, while acetate chitosan sponge (CA‐Ca) was created using the freeze‐drying method with CaCO3 as cross‐linking agents. The addition of CaCO3 enhanced the mechanical strength of the sponges formed by CA, but affected the water absorption performance of the sponge. Both CA and CA‐Ca demonstrated antioxidant properties, with CA‐Ca showing slightly higher maximal scavenging rates for DPPH and hydroxyl radicals compared to CA. Concentrations ranging from 1 to 500 μg/mL of CA and CA‐Ca exhibited a proliferative effect on L929 and RAW264.7 cells. Furthermore, both CA and CA‐Ca promoted the migration of L929 cells, with CA‐Ca showing a higher maximal healing rate within 24 h compared to the control group. Additionally, both materials reduced the levels of TNF‐αand IL‐6 in inflammatory RAW264.7 cells, thereby alleviating the inflammatory response. Moreover, CA and CA‐Ca stimulated collagen secretion in fibroblasts without inducing excessive secretion. CA sponge demonstrated the ability to accelerate in vitro coagulation, while CA‐Ca‐8 (CA:CaCO3 1:8) sponge, prepared with 2% CA, exhibited the most effective coagulation. Overall, CA‐Ca has suitable characteristics such as water absorption, coagulation, cytocompatibility, anti‐inflammatory properties, and promoting cell healing, laying the foundation for its potential clinical applications.
Diagnostic pitfalls in assessment of ferritin following CAR‐T‐cell therapy: Understanding the hook effect
Authors: Harb Roa , Coverdell Tatiana C. , Shalabi Haneen , Shah Nirali N. 
Published: July 2024

AbstractThe hook effect is a well‐described but clinically underappreciated immunoassay interference, where a falsely lowered result is caused by analyte excess. We describe a situation in which ferritin immunoassay results from a 27‐year‐old female with immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome were more than 1000 times lower at a reference laboratory than those determined in‐house after dilution. This case underscores the importance for clinical care providers to be aware of the impact of the hook effect on ferritin measurements, and to promptly communicate with the laboratory when there are discrepancies between clinical symptoms and test results.
A mixed methods examination of teachers' use of bias‐reduction strategies to increase relational equity and the role of the implementation context
Authors: Gaias Larissa M. , Duong Mylien T. , Corbin Catherine M. , Cook Clayton R. , Deveau Mark , Kyoyetera Priscilla , Wood Olivia 
Published: July 2024

AbstractTeachers' racial biases can impact disparities in their perceptions and expectations of students and contribute to inequitable student outcomes. Therefore, interventions that train teachers on strategies for reducing racial biases may hold promise for mitigating inequities. However, research on bias‐reduction interventions in applied contexts is limited and has not focused on examining the implementation of specific strategies or the implementation context. In this study, we used mixed methodology to examine the extent to which teachers (n = 43) use four bias‐reduction strategies, called equity levers (i.e., seeking commonalities, gaining perspective, gathering facts to disprove assumptions, and knowing your vulnerabilities), which are embedded into a student–teacher relationship intervention called Equity‐Explicit Establish‐Maintain‐Restore. In addition, we explored whether any features of the school context support or hinder their implementation of these strategies. We found that teachers implemented the four equity levers and reported increased implementation of these strategies over time. We found quantitative and qualitative evidence of the importance of a strong implementation climate for supporting teachers' use of the equity levers, where teachers collectively value implementing the program and collaborating with one another. This study has implications for both the promise of four specific strategies that can be incorporated into other teacher training to reduce racial bias as well as the importance of establishing strong contextual supports to ensure the successful implementation of equity‐focused strategies.
Research and applications of nanoclays: A review
Authors: Uddin Md. Nur , Hossain Md. Tanvir , Mahmud Nadim , Alam Sadikul , Jobaer Md , Mahedi Sajjatul Islam , Ali Ayub 
Published: July 2024

AbstractNanoclays, a specific type of nanomaterial, have emerged as versatile and dynamic materials, with tremendous potential for advanced functional applications. Despite publishing a large number of research articles, there are relatively few review articles on this topic. This comprehensive review delves into the most widely used nanoclays and explores the diverse range of applications in different fields, such as aerospace, automobile, construction, biomedical, food packaging, and polymer composites. With their ability to enhance the performance of materials and products, nanoclays have become a highly desired material in various industries. The challenges associated with nanoclays like complex properties, difficulty in developing new synthesis methods, and challenges in investigating long‐term durability and stability have been summarized. The future research directions with the exciting possibilities to develop future innovative materials have been highlighted at the end of the article.Highlights
This review provides an extensive examination of the most widely used nanoclays, detailing their properties, types, and limitations.
A summary of publication trends over the last 15 years, based on Scopus data up to 2024, indicates growing interest and research output in nanoclays.
Applications of nanoclays span across aerospace, automobile, construction, biomedical, food packaging, and polymer composites, showcasing their versatility.
Key challenges discussed include complex properties, difficulties in new synthesis methods, and issues in long‐term durability and stability.
Future research directions highlight the potential for developing innovative materials using nanoclays.
Feeding specialization shapes the bottom‐up effect of arbuscular mycorrhizal fungi across a plant–aphid–parasitoid system
Authors: Cascone Pasquale , Iodice Luigi , Gualtieri Liberata , Russo Assunta , Cesaro Patrizia , Yang Zekun , Ruocco Michelina , Monti Maurilia Maria , Massa Nadia , Lingua Guido , Guerrieri Emilio 
Published: July 2024

Societal Impact StatementArbuscular mycorrhizal fungi (AMF) impact the relationships between plants, aphids (insects that feed on plant phloem), and their natural enemies (insects that prey on or parasitize aphids). The presence of AMF influences the growth and population of different aphid species and affects the development of aphid‐killing wasps and their attraction to plants. This research has been conducted also considering the insects' feeding strategy and their feeding specialization. This study provides novel perspectives on how these fungi shape interactions in the natural world, offering potential insights for the development of sustainable pest management strategies in agriculture.Summary

Arbuscular mycorrhizal fungi (AMF) are major root symbionts regulating plant physiology. Their presence affects the performance of aboveground insect herbivores in relation to their feeding strategy and their feeding specialization. For example, the effect of the arbuscular mycorrhizal (AM) symbiosis on chewing insects, positive for specialists and negative for generalists, has been previously demonstrated. Conversely, the impact of AMF on phloem‐suckers with relatively different levels of specialization remains unexplored.
We tested the influence of the AM Funneliformis mosseae on the fitness of the specialist aphid Acyrthosiphon pisum and the generalist aphid Myzus persicae on Vicia faba plants. Further, we investigated the effects of AMF on the higher trophic level, the aphid parasitoids Aphidius ervi (specialist) and Aphidius colemani (generalist), by evaluating plant attractiveness and parasitoid fitness. To support the results of behavioral and biological bioassays we characterized the photosynthetic parameters, the volatilome and the transcriptome of tested plants.
Mycorrhizal plants proved unsuitable for the generalist M. persicae but enhanced the fitness of the specialist A. pisum. The AM symbiosis had no effects on the behavioral response of A. colemani and enhanced the attraction and fitness of A. ervi.
Volatilome and transcriptome profiling corroborated the results of bioassay highlighting a bottom‐up effect of the AMF across a plant–aphid–parasitoid system.
Effects of high‐definition transcranial direct current stimulation combined with inspiratory muscle training for treating respiratory sequelae of long COVID: A case series
Authors: de Souza Iara Tainá C. , dos Santos Ewerton Graziane G. , da Costa Roberto Vinicius A. , Ferreira Wanessa do N. , Santana Kelly de J. , Felix João Victor dos S. , Brandão Celso B. F. , Candeia Aline A. , Nascimento Laura Morgana dos S. , da Silva Ana Catarine T. , Ferreira Carlos André S. , Queiroz Maria Heloísa B. S. , Silva Jackeline S. , Lima José Heriston de M. , Pedrosa Rafaela , Onofre Tatiana , de França Eduardo E. T. 
Published: July 2024

AbstractIntroductionLong COVID occurs when numerous symptoms begin 3 weeks after acute infection and last for 12 months or more. High‐definition transcranial direct current stimulation (HD‐tDCS) has been tested in patients with COVID‐19; however, previous studies did not investigate the HD‐tDCS use combined with inspiratory muscle training (IMT) for respiratory sequelae of long COVID.Case presentationSix individuals (four women and two men) aged between 29 and 71 years and presenting with respiratory sequelae of long COVID were included. They were submitted to an intervention that comprised HD‐tDCS combined with IMT twice a week for 5 weeks. Lung function and respiratory muscle assessments were performed at baseline and after 5 weeks of intervention.Implications on physiotherapy practiceHD‐tDCS may enhance the IMT effects by increasing respiratory muscle strength, efficiency, and lung function of individuals with long COVID.
Dose optimization of cefazolin in South African children undergoing cardiac surgery with cardiopulmonary bypass
Authors: Gebreyesus Manna Semere , Dresner Alexandra , Wiesner Lubbe , Coetzee Ettienne , Verschuuren Tess , Wasmann Roeland , Denti Paolo 
Published: July 2024

AbstractCefazolin is an antibiotic used to prevent surgical site infections. During cardiac surgery with cardiopulmonary bypass (CPB), its efficacy target could be underachieved. We aimed to develop a population pharmacokinetic model for cefazolin in children and optimize the prophylactic dosing regimen. Children under 25 kg undergoing cardiac surgery with CPB and receiving cefazolin at standard doses (50 mg/kg IV every 4–6 h) were included in this analysis. A population pharmacokinetic model and Monte Carlo simulations were used to evaluate the probability of target attainment (PTA) for efficacy and toxicity with the standard regimen and an alternative regimen of continuous infusion, where loading and maintenance doses were calculated from model‐derived individual parameters. Twenty‐two patients were included, with median (range) age, body weight, and eGFR of 19.5 (1–94) months, 8.7 (2–21) kg, and 116 (48–159) mL/min, respectively. Six patients received an additional dose in the CPB circuit. A two‐compartment disposition model with an additional compartment for the CPB was developed, including weight‐based allometric scaling and eGFR. For a 10 kg patient with eGFR of 120 mL/min/1.73 m2, clearance was estimated as 0.856 L/h. Simulations indicated that the standard dosing regimen fell short of achieving the efficacy target >40% of the time within a dosing duration and in patients with good renal function, PTA ranged from <20% to 70% for the smallest to the largest patients, respectively, at high MICs. In contrast, the alternative regimen consistently maintained target concentrations throughout the procedure for all patients while using a lower overall dose.
Allergic bronchopulmonary aspergillosis with metachronous isolation of three distinct Aspergillus species
Authors: Sasahara Yosuke , Akata Kentaro , Yamasaki Kei , Orihashi Takeshi , Yatera Kazuhiro 
Published: July 2024

AbstractAllergic bronchopulmonary aspergillosis (ABPA) is an inflammatory disease induced by exaggerated immune responses to Aspergillus species. Although ABPA has a high recurrence (48%), its instances with sequential isolation of distinct Aspergillus species are sporadic. Only one case report has documented the metachronous isolation of Aspergillus fumigatus and Aspergillus flavus. However, no reported cases of metachronous isolation involving three distinct Aspergillus species exist. Herein, we report a novel case of a 47‐year‐old Japanese man with sequential metachronous isolation of A. flavus, A. terreus, and A. fumigatus. Initially presenting with symptoms of productive cough and pulmonary infiltration, the patient experienced two relapses following treatment with oral prednisolone. Adjustments in therapy, including voriconazole and a tailored corticosteroid regimen, resulted in significant improvement without relapse for over 6 months. This case report highlights the challenges and successful management of ABPA involving multiple Aspergillus species.
Semihierarchical reconstruction and weak‐area revisiting for robotic visual seafloor mapping
Authors: She Mengkun , Song Yifan , Nakath David , Köser Kevin 
Published: July 2024

AbstractDespite impressive results achieved by many on‐land visual mapping algorithms in the recent decades, transferring these methods from land to the deep sea remains a challenge due to harsh environmental conditions. Images captured by autonomous underwater vehicles, equipped with high‐resolution cameras and artificial illumination systems, often suffer from heterogeneous illumination and quality degradation caused by attenuation and scattering, on top of refraction of light rays. These challenges often result in the failure of on‐land Simultaneous Localization and Mapping (SLAM) approaches when applied underwater or cause Structure‐from‐Motion (SfM) approaches to exhibit drifting or omit challenging images. Consequently, this leads to gaps, jumps, or weakly reconstructed areas. In this work, we present a navigation‐aided hierarchical reconstruction approach to facilitate the automated robotic three‐dimensional reconstruction of hectares of seafloor. Our hierarchical approach combines the advantages of SLAM and global SfM that are much more efficient than incremental SfM, while ensuring the completeness and consistency of the global map. This is achieved through identifying and revisiting problematic or weakly reconstructed areas, avoiding to omit images and making better use of limited dive time. The proposed system has been extensively tested and evaluated during several research cruises, demonstrating its robustness and practicality in real‐world conditions.
Tradition, entrepreneurship, and innovation: The craft of Japanese fine dining
Authors: Yamauchi Yutaka , Hjorth Daniel 
Published: July 2024

AbstractResearch SummaryThis study explores how traditional craft produces novelty, which appears to be at odds with its emphasis on continuation. While prior research has explored how tradition is rediscovered and revived from the past, traditional craft can produce intrinsic novelty potentially through its own repetitive acts. This study examines a Japanese cuisine Kaiseki, which is traditional but simultaneously innovative. The analysis of a well‐known chef's design processes reveals that the chef designs novel dishes by responding to what has been done before, making something better and differently and thereby going beyond the limit of the tradition; Kaiseki tradition is re‐enacted through such practices. A process philosophy of Gills Deleuze is engaged to explain our concept of “tradition as capacity” as well as “tradition as object.”Managerial SummaryTradition is now seen as important source of value. This study explains how craft can be both traditional and innovative. Typically, innovation has been explained by recombination with new technologies and restoration and reinterpretation to reinvigorate identity rooted in the past, this study sheds light on the intrinsic novelty within the practices of craft. This novelty is evident in traditional Japanese cuisine, called Kaiseki, which is traditional but also innovative because customers seek novel exquisite experience as they do in any Michelin Guide starred restaurants. Through the analysis of a chef's practices, we propose a new conceptualization of tradition as capacity. The creative force of this tradition as capacity is important for creating new opportunities and novel values.
Novel Formulations of Humic acid, Lignin, and Lignite Grafted Hydrogels for the Slow Release of Thiamethoxam
Authors: Manu  , Kumar Devendra , Gupta Rajinder K. 
Published: July 2024

AbstractThe objective of this study is to explore the novel use of natural polymers like Humic acid, Lignin, and Lignite based hydrogels for the formulation of pesticides and fertilizers that would reduce the residues in soil and run‐off water that pose a threat to human health and the environment. We synthesized hydrogels by grafting Humic acid, lignin, and lignite onto acrylic acid with N′N‐methylene bisacrylamide (MBA) for the ex‐situ encapsulation of thiamethoxam, a common pesticide. Various characterization techniques including Fourier‐transform infrared spectroscopy, Carbon‐13 Solid‐state Cross‐Polarization Magic Angle Spinning Nuclear Magnetic Resonance, X‐ray diffraction, Thermogravimetric Analysis, and Rheology were employed. The release kinetics of thiamethoxam in water from the developed formulations were analyzed using the Korsmeyer‐ Peppas model and the Weibull model. Humic acid and lignin‐based hydrogels exhibited a long‐sustained release for 49 hours, followed by lignite‐based hydrogels (38 hours). According to ANOVA results, the change of biopolymer proved to be an effective factor in reducing the water evaporation rate, which decreased from 99 % to 72.85 % in the soil amended with synthesized hydrogels. In conclusion, the novel formulations of humic acid, lignin, and lignite exhibit potential as slow‐release vehicles for pesticides and fertilizers. This study provides valuable insights for the research community, addressing the need to develop effective strategies for mitigating pesticide residues in soil and water bodies.
Synthesis and Characterization of Polymer Particles as Metal‐Free Catalysts for Electrooxidation and Methanolysis of Sodium Borohydride
Authors: Gokkus Kutalmis , Kaya Sefika , Yildiz Derya , Saka Ceren , Gür Mahmut , Bütün Vural , Kivrak Hilal 
Published: July 2024

AbstractIn this study, trimethylolpropane triglycidyl ether/diethylenetriamine (TD) and glutaraldehyde/diethylenetriamine (GD) polymer particles are synthesized as catalysts for hydrogen production from NaBH4 methanolysis and NaBH4 electrooxidation. SEM, FT‐IR and TGA characterization methods are applied to determine the surface morphologies, chemical structures, thermal stability and decomposition of the synthesized polymer particles. The parameters affecting the hydrogen generation rate on NaBH4 methanolysis are investigated and optimum conditions are determined. Under optimum conditions, the hydrogen generation rates of TD and GD polymer particles are obtained as 34903.2 and 97998 mL/min.gcat, respectively. The activation energies of TD and GD polymer particles are also calculated as 16.86 and 18.14 kJ/mol, respectively. The catalytic activities of polymer particles as anode catalysts in NaBH4 electrooxidation are determined by CV, CA, EIS analyses. The specific activities of TD and GD polymer particles are acquired as 0.54 and 0.64 mA/cm2, respectively. These results indicate that the synthesized polymer particles are promising catalysts for electrooxidation and methanolysis of sodium borohydride.
Flavonoids from Pancratium aegyptiacum M. Roem.: Exploring the Potential Anti‐Alzheimer's Activity through Network Pharmacology and In Silico Analysis
Authors: Ragab Nermin A. , El Shabrawy Mona O. , Farid Mai M. , Marzouk Mona M. 
Published: July 2024

AbstractThe repurposing of therapeutic and preventive strategies against Alzheimer's disease (AD) is progressing rapidly. Pancratium aegyptiacum has been found to possess considerable anticholinesterase potential attributed to its alkaloid contents. In this study, the potential anti‐Alzheimer's activity of isolated flavonoids from P. aegyptiacum was investigated through computational analysis, focusing on the flavonoids rather than their well‐known alkaloids. Molecular docking was performed against three crucial targets involved in the development of AD, and the isolated phytoconstituents were analysed against these targets. Pathway enrichment analyses were also established, additionally, ADMETlab and PASS web servers predicted the pharmacological properties and potential biological functions of the isolated flavonoids. The phytochemical analysis of P. aegyptiacum aerial parts revealed the isolation and identification of eleven flavonoids. They were identified as derivatives of kaempferol (Km), quercetin (Qn) and isorhamnetin (Is). Our investigation revealed that these phytoconstituents potentially act against AD, with several phytochemicals showing superior binding affinity against essential AD targets. The Kyoto Encyclopaedia of Genes and Reactome pathway enrichment database revealed that isolated phytochemicals may have a role in regulating the immune pathway directly correlated to AD. Additionally, these phytochemicals exhibited lower toxicity with pleiotropic biological activities, including dementia treatment and neurotrophic factor enhancement.
Assessment of 3‐Amino‐Benzoic Acid Methyl Ester Derivatives as Glutathione S‐Transferase and Glutathione Reductase Inhibitor: Supported by Molecular Docking Studies
Authors: Korkmaz Işıl Nihan , Güller Pınar , Kalın Ramazan , Özdemir Hasan 
Published: July 2024

AbstractGSTs catalyze detoxification reactions of harmful xenobiotics via conjugation with glutathione (GSH) while glutathione reductase (GR) is the sole enzyme that acts in the recovery reaction of GSH from oxidized glutathione (GSSG). In this study, in vitro inhibitory impacts of 3‐amino‐benzoic acid methyl ester compounds on GR and GST were investigated. For this firstly, GR and GST were obtained from human blood with specific activity of 6.26 EU/mg protein and 8.57 EU/mg protein respectively. Then, inhibition studies were performed. It was found that methyl 3‐amino‐5‐chlorobenzoate had the highest inhibitory effect on hGR with Ki value of 0.524±0.109 μM) and methyl 3‐amino‐4‐nitrobenzoate was the most effective inhibitor on hGST with Ki value of 37.05±4.487 μM. Besides, molecular docking analysis was used to estimate the binding energies of molecules. Methyl 3‐amino‐4‐nitrobenzoate and methyl 3‐amino‐4‐chlorobenzoate were predicted to have the highest binding affinity into GR and GST receptors respectively.