bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization of miR‐210 in 3T3‐L1 adipogenesis
Authors: Liang Wei‐Cheng , Wang Yan , Wan David Chi‐Cheong , Yeung Venus Sai‐Ying , Waye Mary Miu‐Yee 
Published: June 2013

AbstractAlthough accumulating evidences indicate that miRNA emerge as a vital player in cell growth, development, and differentiation, how they contribute to the process of adipocyte differentiation remains elusive. In the present study, we revealed that the expression level of miR‐210 was dramatically upregulated during 3T3‐L1 adipogenesis. Ectopic introduction of miR‐210 into 3T3‐L1 cells promoted terminal differentiation as well as the expression of adipogenic markers. MTT assay showed that miR‐210 significantly inhibited cell proliferation whereas the BrdU incorporation assay and flow cytometry analysis showed that miR‐210 did not impair G1/S phase transition. Further experiments demonstrated that enhanced expression of miR‐210 in 3T3‐L1 cells provoked adipocyte differentiation via activation of PI3K/Akt pathway by targeting SHIP1, a negative regulator of PI3K/Akt pathway. Moreover, blockade of endogenous miR‐210 during adipogenesis significantly repressed adipocyte differentiation. In summary, we have identified miR‐210 as an important positive regulator in adipocyte differentiation through the activation of PI3K/Akt pathway. J. Cell. Biochem. 114: 2699–2707, 2013. © 2013 Wiley Periodicals, Inc.
Exogenous polyamines promote osteogenic differentiation by reciprocally regulating osteogenic and adipogenic gene expression
Authors: Lee Mon‐Juan , Chen Yuhsin , Huang Yuan‐Pin , Hsu Yi‐Chiang , Chiang Lan‐Hsin , Chen Tzu‐Yu , Wang Gwo‐Jaw 
Published: June 2013

ABSTRACTPolyamines are naturally occurring organic polycations that are ubiquitous in all organisms, and are essential for cell proliferation and differentiation. Although polyamines are involved in various cellular processes, their roles in stem cell differentiation are relatively unexplored. In this study, we found that exogenous polyamines, putrescine, spermidine, and spermine, promoted osteogenic differentiation of human bone marrow‐derived mesenchymal stem cells (hBMSCs) without inducing cell death or apoptosis. Alkaline phosphatase (ALP) activity and the mRNA level of osteogenic genes, including Runx2, ALP, osteopontin, and osteocalcin, were up‐regulated by exogenous polyamines. When hBMSCs were cultured at high cell density favoring adipocyte formation, exogenous polyamines resulted in down‐regulation of adipogenic genes such as PPARγ, aP2, and adipsin. Extracellular matrix mineralization, a marker for osteoblast maturation, was enhanced in the presence of exogenous polyamines, while lipid accumulation, an indication of adipogenic differentiation, was attenuated. Exogenous polyamines increased the mRNA expression of polyamine‐modulated factor 1 (PMF‐1) and its downstream effector, spermidine/spermine N1‐acetyltransferase (SSAT), while that of ornithine decarboxylase (ODC), the rate‐limiting enzyme in polyamine biosynthesis, was suppressed. These results lead to possible connections between polyamine metabolism and osteogenic differentiation pathways. To summarize, this study provides evidence for the involvement of polyamines in osteogenic differentiation of hBMSCs, and is the first to demonstrate that osteogenic and adipogenic differentiation are reciprocally regulated by exogenous polyamines. J. Cell. Biochem. 114: 2718–2728, 2013. © 2013 Wiley Periodicals, Inc.
Testing Three Different Sequential Mediational Interpretations of Beck's Cognitive Model of the Development of Depression
Authors: Pössel Patrick , Black Stephanie Winkeljohn 
Published: June 2013

ObjectivesThis study tested and compared three sequential interpretations of Beck's cognitive model of the development of depression (1996). The causal mediational interpretation identifies dysfunctional attitudes as most distal to depressive symptoms, followed by cognitive distortions, the cognitive triad, and negative automatic thoughts, with each construct successively more proximal to depressive symptoms. By contrast, the symptom model reverses the causal chain with negative automatic thoughts as the most proximal consequence and dysfunctional attitudes as the most distal consequence of depression. The bidirectional model merges both interpretations into one model. Previous studies on sequential interpretations of Beck's model have not included cognitive distortions or the cognitive triad and did not test the bidirectional model finding contradictory empirical evidence for the sequential order.MethodIn the 3‐wave longitudinal study, 308 German university students without clinically significant depressive symptoms (245 female, average age: 23.69 years) completed self‐report questionnaires measuring their dysfunctional attitudes, cognitive distortions, cognitive triad, negative automatic thoughts, and depressive symptoms.ResultsThe bidirectional model with partial mediation fit the data best and cognitive distortions mediated the relationship between dysfunctional attitudes and negative automatic thoughts and vice versa.ConclusionsThe findings have important consequences for the prevention of depression. Prevention programs may want to focus on cognitive distortions, the only construct in Beck's model that influences every other construct in the model.
Premenstrual Disorders and Rumination
Authors: Craner Julia R. , Sigmon Sandra T. , Martinson Amber A. , McGillicuddy Morgan L. 
Published: June 2013

ObjectivesPremenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD) involve emotional, behavioral, and physical symptoms; however, there is little understanding of psychological factors that contribute to these disorders. It was hypothesized that rumination, a form of depressive self‐focused attention, is related to premenstrual distress.MethodStudy 1 involved women (N = 735) meeting criteria for No/Mild PMS, Moderate/Severe PMS, and PMDD using retrospective self‐report. Study 2 involved women (N = 85) meeting diagnostic criteria for PMS or PMDD (i.e., PMD group) and healthy controls (i.e., No PMD group) following 60‐day symptom monitoring. Participants in both studies completed questionnaires of rumination, anxiety sensitivity, and coping styles.ResultsRumination was strongly related to premenstrual disorders using both retrospective and prospective reports, as well as both categorical and continuous approaches to classification of premenstrual distress.ConclusionsRumination, a transdiagnostic factor in psychopathology, may contribute to the onset and maintenance of premenstrual distress.
Hepatitis A and hepatitis B infection prevalence and associated risk factors in men who have sex with men, Bangkok, 2006–2008
Authors: Linkins Robert W. , Chonwattana Wannee , Holtz Timothy H. , Wasinrapee Punneeporn , Chaikummao Supaporn , Varangrat Anchalee , Tongtoyai Jaray , Mock Philip A. , Curlin Marcel E. , Sirivongrangson Pachara , van Griensven Frits , McNicholl Janet M. 
Published: June 2013

AbstractDespite the availability of safe and effective vaccines, little is known about prevalence and risk factors for hepatitis A (HAV) and hepatitis B virus (HBV) infection among Thai men who have sex with men. The prevalence of HAV and HBV infection among men who have sex with men cohort in Bangkok was assessed. Baseline blood specimens were drawn and demographic and behavioral data were collected. Bivariate and multivariate logistic regression analysis was used to analyze risk factors for prevalent HAV and HBV infection. One thousand two hundred ninety‐nine Thai men who have sex with men 18 years and older were enrolled. Among those with results, 349/1,291 (27.0%) had evidence of past or current hepatitis A infection. Of the 1,117 (86.5%) men with unambiguous HBV test results, 442 (39.6%) had serologic evidence of past/current infection, 103 (9.2%) were immune due to hepatitis B vaccination, 572 (51.2%) had no evidence of immunological exposure to HBV or vaccine. Of those with past/current HBV infection, 130 (29.4%) were HIV positive. Age >35 years was independently associated with both HAV and HBV infection. University education was protective against both HAV and HBV infection. Increased alcohol consumption, number of lifetime male sexual partners ≥10, and prevalent HIV infection were also independently associated with HBV infection. The prevalence of past/current HAV and HBV infection was high in Bangkok men who have sex with men. Age‐cohorts with a higher prevalence of hepatitis B vaccine induced immunity may be expected in the future. Hepatitis A and B vaccination is recommended. J. Med. Virol. 85:1499–1505, 2013. © 2013 Wiley Periodicals, Inc.†
Mechanism of Iron Oxide Formation from Iron Pentacarbonyl‐Doped Low‐Pressure Hydrogen/Oxygen Flames
Authors: Wlokas I. , Faccinetto A. , Tribalet B. , Schulz C. , Kempf A. 
Published: June 2013

ABSTRACTA chemical reaction mechanism was developed for the formation of iron oxide (Fe2O3) from iron pentacarbonyl (Fe(CO)5) in a low‐pressure hydrogen–oxygen flame reactor. In this paper, we describe an extensive approach for the flame‐precursor chemistry and the development of a novel model for the formation of Fe2O3 from the gas phase. The detailed reaction mechanism is reduced for the implementation in two‐dimensional, reacting flow simulations. The comprehensive simulation approach is completed by a model for the formation and growth of the iron oxide nanoparticles. The exhaustive and compact reaction mechanism is validated using experimental data from iron‐atom laser‐induced fluorescence imaging. The particle formation and growth model are verified with new measurements from particle mass spectrometry.
Rate Constants for the Gas‐Phase Reactions of Ozone and Nitrate Radicals with the Sesquiterpenes: Valencene and Farnesol
Authors: Ham Jason E. 
Published: June 2013

ABSTRACTSesquiterpenes are constituents of a variety of essential oils that are used in flavorings, perfumes, personal care, and cleaning products. Two sesquiterpenes that are commonly used as indoor fragrances are valencene and farnesol. Knowing the reaction rate constants of these chemicals with ozone (O3) and nitrate radical () is an important factor in determining their fate indoors. In this study, the bimolecular rate constants of , , , and were measured using the relative rate technique at 297 ± 3 K and 1 atm total pressure. Using the rate constants reported here and measured/modeled indoor concentrations of O3 and (20 ppb and 1 ppt, respectively), pseudo–first‐order‐rate lifetimes , , , and were determined.
Kinetic Investigation of Oxidation of Aromatic Anils by Potassium Peroxymonosulfate in Aqueous Acidic Medium
Authors: Venkatesh R. , Karunakaran K. 
Published: June 2013

ABSTRACTThe kinetics of oxidation of aromatic anils to benzaldehyde and azobenzene by potassium peroxymonosulfate has been studied in aqueous acetic acid medium. The low dielectric constant of the medium facilitates the reactivity. It has been found that the variation in the ionic strength of the reaction has a negligible effect on the rate. Similarly, polymerization was not observed when acrylonitrile was added to the reaction mixture. This observation rules out the formation of any free radical in the reaction. The added Mn(II) increases the rate of the reaction, which indicates the involvement of two‐electron transfer. Highly negative ∆S# values indicate a structured transition state. The deviation of the Hammett plot was noted, and a concave downward curve was obtained for the anils with substituents in the aniline moiety. The observed break in the log kobs versus σ is attributed to the transition state whereas the concave upward curve was observed for the substituents in the benzaldehyde moiety and in the combination of aniline and benzaldehyde moieties, and a suitable mechanism was proposed.
Tumor perfusion‐related parameter of diffusion‐weighted magnetic resonance imaging: Correlation with histological microvessel density
Authors: Lee Hye‐Jeong , Rha Sun Young , Chung Yong Eun , Shim Hyo Sub , Kim Young Jin , Hur Jin , Hong Yoo Jin , Choi Byoung Wook 
Published: June 2013

PurposeWe obtained intravoxel incoherent motion (IVIM) parameters through biexponential analysis on diffusion‐weighted MR imaging (DWI) using multiple b values. Correlation was evaluated between these parameters and histological microvessel density (MVD) for the possibility of noninvasive evaluation of MVD with DWI.MethodsTwenty‐five nude mice with the HT29 colorectal cancer cells implanted were analyzed after undergoing DWI with multiple b values (0, 50, 100, 300, 500, 700, and 1000 s/mm2). Tissue diffusivity (Dt), pseudo‐diffusion coefficient (Dp), and perfusion fraction (fp) were calculated using a biexponential analysis, and these parameters were correlated with MVD. The MVD was determined with the CD31 stain. For statistical analysis, Spearman's rank correlation was applied.ResultsThe mean value and correlation coefficient with MVD for each IVIM parameter were as follows: Dt = 0.98 ± 0.06 × 10−3 mm2/s with r = 0.139 (P = 0.508); Dp = 23.70 ± 7.94 × 10−3 mm2/s with r = 0.782 (P < 0.001); and fp = 15.58 ± 5.7% with r = 0.749 (P < 0.001). Dp and fp showed significant correlation with MVD, but Dt did not.ConclusionThe IVIM parameters, Dp and fp, on DWI might be used in the noninvasive evaluation of MVD. Magn Reson Med 71:1554–1558, 2014. © 2013 Wiley Periodicals, Inc.
Mapping aortic hemodynamics using 3D cine phase contrast magnetic resonance parallel imaging: Evaluation of an anisotropic diffusion filter
Authors: Tresoldi D. , Cadioli M. , Ponzini R. , Esposito A. , De Cobelli F. , Morbiducci U. , Rizzo G. 
Published: June 2013

PurposeTo propose and evaluate an anisotropic diffusion filter to improve visualization and analysis of the thoracic aorta local hemodynamics from phase‐contrast MRI sensitivity encoding imaging.MethodsThe filter parameters were tailored to the phase‐contrast MRI sensitivity encoding data, using a simple calibration procedure. The filter was applied to 20 phase‐contrast MR image studies (five subjects acquired with four different sensitivity encoding reduction factors). The filter effect was estimated with respect to image quality (noise in velocity images, σn), regularity of the velocity fields (divergence; relative error in velocity magnitude, and absolute error in flow direction), aorta flow pattern visualization (streamlines, secondary flows) and flow rate quantification.Resultsσn decreased up to three times, divergence, error in velocity magnitude, and absolute error in flow direction decreased (by at least 313, 40, and 10%, respectively), indicating less noisy and more regular velocity fields after filtering. Streamline analysis confirmed the beneficial effect of anisotropic diffusion filter, both visually and quantitatively (streamline numbers increased by 207% in whole cardiac cycle and by 180% in systolic phase). A high correlation (r = 0.99) between the prefiltering and postfiltering aortic flow rate values was found.ConclusionThe anisotropic diffusion filter approach can be considered effective in improving the visualization and analysis of the thoracic aorta hemodynamics from phase‐contrast MRI sensitivity encoding images. Magn Reson Med 71:1621–1631, 2014. © 2013 Wiley Periodicals, Inc.
GEOPHYSICAL CHARACTERIZATION OF THE CHICXULUB IMPACT CRATER
Authors: Gulick S.P.S. , Christeson G.L. , Barton P.J. , Grieve R.A.F. , Morgan J.V. , Urrutia‐Fucugauchi J. 
Published: June 2013

AbstractGeophysical data indicate that the 65.5 million years ago Chicxulub impact structure is a multi‐ring basin, with three sets of semicontinuous, arcuate ring faults and a topographic peak ring (PR). Slump blocks define a terrace zone, which steps down from the inner rim into the annular trough. Fault blocks underlie the PR, which exhibits variable relief, due to target asymmetries. The central structural uplift is >10 km, and the Moho is displaced by 1–2 km. The working hypothesis for the formation of Chicxulub is: a 50 km radius transient cavity, lined with melt and impact breccia, formed within 10 s of the impact, and within minutes, weakened rebounding crust rose kilometers above the surface, the transient crater rim underwent localized deformation and collapsed into large slump blocks, resulting in a inner rim at 70–85 km radius, and outer ring faults at 70–130 km radius. The overheightened structural uplift collapsed outward, buried the inner slump blocks, and formed the PR. Most of the impact melt was ultimately emplaced as a coherent <3 km thick melt sheet within the central basin that shallows within the inner regions of the PR. Smaller pockets of melt flowed into the annular trough. Subsequently, slope collapse, ejecta, ground surge, and tsunami waves infilled the annular trough and annular basin with sediments up to 3 km and 900 m thick, respectively. Testing this working hypothesis requires direct observation of the impactites, within and adjacent to the PR and central basin.
Global warming potentials and radiative efficiencies of halocarbons and related compounds: A comprehensive review
Authors: Hodnebrog Ø. , Etminan M. , Fuglestvedt J. S. , Marston G. , Myhre G. , Nielsen C. J. , Shine K. P. , Wallington T. J. 
Published: June 2013

AbstractIn the mid‐1970s, it was recognized that chlorofluorocarbons (CFCs) were strong greenhouse gases that could have substantial impacts on radiative forcing of climate change, as well as being substances that deplete stratospheric ozone. Around a decade later, this group of radiatively active compounds was expanded to include a large number of replacements for ozone‐depleting substances such as chlorocarbons, hydrochlorocarbons, hydrochlorofluorocarbons (HCFCs), hydrofluorocarbons (HFCs), perfluorocarbons (PFCs), bromofluorocarbons, and bromochlorofluorocarbons. This paper systematically reviews the published literature concerning the radiative efficiencies (REs) of CFCs, bromofluorocarbons and bromochlorofluorocarbons (halons), HCFCs, HFCs, PFCs, sulfur hexafluoride, nitrogen trifluoride, and related halogen containing compounds. In addition, we provide a comprehensive and self‐consistent set of new calculations of REs and global warming potentials (GWPs) for these compounds, mostly employing atmospheric lifetimes taken from the available literature. We also present global temperature change potentials for selected gases. Infrared absorption spectra used in the RE calculations were taken from databases and individual studies and from experimental and ab initio computational studies. Evaluations of REs and GWPs are presented for more than 200 compounds. Our calculations yield REs significantly (> 5%) different from those in the Intergovernmental Panel on Climate Change Fourth Assessment Report (AR4) for 49 compounds. We present new RE values for more than 100 gases which were not included in AR4. A widely used simple method to calculate REs and GWPs from absorption spectra and atmospheric lifetimes is assessed and updated. This is the most comprehensive review of the radiative efficiencies and global warming potentials of halogenated compounds performed to date.
On some applications of bayesian methods in cancer clinical trials
Authors: Greenhouse Joel B. 
Published: June 2013

AbstractThe NCCTG randomized controlled clinical trial for the treatment of avanced colorectal carcinoma is a wonderful case study of the dynamic interplay between scientific learning and statistical inference. Ethical concerns for minimizing the number of patients assigned to an inferior treatment and interest in identifying subsets of patients for whom a treatment is most likely efficacious pose challenging problems for the practice of statistics. In the first part of this paper, I comment on the applications of Bayesian methods to these problems in the NCCTG trial as presented by Freedman and Spieglehalter and Dixon and Simon, respectively. In the second part of this paper, I discuss and illustrate a Bayesian approach to model sensitivity analysis with a particular focus on model specification and criticism. The Bayesian approach provides a formal methodology to assess the sensitivity of inferences to the inputs into an analysis so that it is possible to investigate the consequences of the specification of the model. I apply these methods to the specification and criticism of a class of survival models for the analysis of survival times in the NCCTG trial.
The correlation between heart period variability and mean period length
Authors: Fleiss J. L. , Bigger J. T. , Rolnitzky L. M. 
Published: June 2013

AbstractHeart rate variability and heart period variability are important indicators of the functioning of the autonomic nervous system and are strong predictors of survival after myocardial infarction. The standard deviation of a patient's series of normal heart periods (consecutive normal RR intervals) is positively and, in some populations, strongly correlated with the mean period length. This phenomenon has led some investigators to use the coefficient of variation as their measure of variability, because it correlates less strongly with the mean period length. Using data from a multicentre post‐infarction natural history study, we show that the standard deviation of the instantaneous heart rates has, like the coefficient of variation, only a modest correlation with the mean period length. Unlike the coefficient of variation, however, this standard deviation is derivable from established statistical principles. We show further that the coefficient of variation, the standard deviation of heart rates, and the standard deviation of heart periods are approximately equally strong predictors of survival after myocardial infarction.
Bootstraps, permutation tests, and sampling orders of magnitude faster using SAS®
Authors: Opdyke John D. (“J.D.”) 
Published: June 2013

While permutation tests and bootstraps have very wide‐ranging application, both share a common potential drawback: as data‐intensive resampling methods, both can be runtime prohibitive when applied to large‐ or even medium‐sized data samples drawn from large datasets. The data explosion over the past few decades has made this a common occurrence, and it highlights the increasing need for faster, and more efficient and scalable, permutation test and bootstrap algorithms. Seven bootstrap and six permutation test algorithms coded in SAS (the largest privately owned software firm globally) are compared herein. The fastest algorithms (‘OPDY’ for the bootstrap, ‘OPDN’ for permutation tests) are new, use no modules beyond Base SAS, and achieve speed increases orders of magnitude faster than the relevant ‘built‐in’ SAS procedures (OPDY is over 200× faster than Proc SurveySelect; OPDN is over 240× faster than Proc SurveySelect, over 350× faster than NPAR1WAY (which crashes on datasets less than a 10th the size OPDN can handle), and over 720× faster than Proc Multtest). OPDY also is much faster than hashing, which crashes on datasets smaller—sometimes by orders of magnitude—than OPDY can handle. OPDY is easily generalizable to multivariate regression models, and OPDN, which uses an extremely efficient draw‐by‐draw random‐sampling‐without‐replacement algorithm, can use virtually any permutation statistic, so both have a very wide range of application. And the time complexity of both OPDY and OPDN is sublinear, making them not only the fastest but also the only truly scalable bootstrap and permutation test algorithms, respectively, in SAS. WIREs Comput Stat 2013. doi: 10.1002/wics.1266This article is categorized under:

Statistical and Graphical Methods of Data Analysis > Bootstrap and Resampling
Statistical and Graphical Methods of Data Analysis > Nonparametric Methods
Software for Computational Statistics > Software/Statistical Software