bluuebunny/crossref_metadata_2025_split huggingface dataset:
Kinetics of luminescence of CsI single crystals scavenged by Y3+
Authors: Cherginets V. L. , Rebrova T. P. , Datsko Yu. N. , Ponomarenko T. V. , Yavetsky R. P. , Pedash V. Yu. 
Published: January 2013

AbstractCsI single crystals were grown from the melt scavenged by Y3+ (YCl3) addition in 6.7·10−4–6.7·10−3 mol·kg−1 range. The addition of the scavenger amounts comparable with the total concentration of the oxygen‐containing admixtures in molten CsI results in complete destruction of the latter. Because of this, the intensity of the band with a maximum at 2.8 eV in radioluminescence spectra caused by the oxygen‐containing admixtures (anion vacancies) considerably decreases, and the fraction of the slow 2μs‐component corresponding to these admixtures becomes lower than 0.01 (0.007). The addition of larger quantities of YCl3 leads to the appearance of a wide band with a maximum at 2.8 eV caused by cation vacancies, and the intensity of the slow 2μs‐component increases to 0.02. The maximum ratio of two faster components with the decay constants equal to 7 and 30 ns reaches 0.65:0.33 at Y3+ concentration in CsI melt equal to 6.7·10‐3 mol·kg‐1, the effective luminescence time of fastest components is ca 14 ns. The dependence of the ‘Fast/Total ratio’ on Y3+ concentration passes through its maximum (0.81) corresponding to the equivalence of Y3+ and O2− concentrations in the growth CsI melt.
Developments in the Coordination Chemistry of Phosphinines
Authors: Müller Christian , Broeckx Leen E. E. , de Krom Iris , Weemers Jarno J. M. 
Published: January 2013

AbstractInvited for this month's cover is the group of Christian Müller at the Freie Universität Berlin. The image shows the most recent developments in the coordination chemistry of functionalized, π‐accepting phosphinines.
Fast Inline Roll‐to‐Roll Printing for Indium‐Tin‐Oxide‐Free Polymer Solar Cells Using Automatic Registration
Authors: Hösel Markus , Søndergaard Roar R. , Jørgensen Mikkel , Krebs Frederik C. 
Published: January 2013

AbstractFast inline roll‐to‐roll printing and coating on polyethylene terephthalate (PET) and barrier foil was demonstrated under ambient conditions at web speeds of 10 m min−1 for the manufacture of indium‐tin‐oxide‐free (ITO‐free) polymer solar cells comprising a 6‐layer stack: silver‐grid/PEDOT:PSS/ZnO/P3HT:PCBM/PEDOT:PSS/silver‐grid. The first and second layers were printed at the same time using inline processing at a web speed of 10 m min−1 where flexographic printing of a hexagonal silver grid comprises the first layer followed by rotary‐screen printing of a PEDOT:PSS electrode as the second layer. The third and fourth layers were slot‐die coated at the same time again using inline processing at a web speed of 10 m min−1 of firstly zinc oxide as the electron transport layer followed by P3HT:PCBM as the active layer. The first three layers (silver‐grid/PEDOT:PSS/ZnO) comprise a generally applicable ITO‐free, semitransparent, electron‐selective front electrode for inverted polymer solar cells. This electrode shows a low sheet resistance (∼10 Ω/□) and good optical transmission in the visible range (∼60 %). The solar cell stack was completed by rotary‐screen printing of a hole‐collecting PEDOT:PSS layer at 2 m min−1 and a comb‐patterned silver‐grid back electrode at the same speed. The solar cells were post processed by using fast roll‐to‐roll switching to a functional state.
Use of the ecosystem services concept in landscape management in the Netherlands
Authors: van Wensem Joke 
Published: January 2013

Abstract
Increasing reference to the ecosystem services (ES) concept is made in publications on the need to use natural resources sustainably, to protect and enhance biodiversity, and to alleviate poverty in developing countries. To examine the significance of the concept in densely populated industrialized countries, this case study investigates its use in several sustainable landscape management projects in the Netherlands. Guidance by the Economics of Ecosystems and Biodiversity project (TEEB) for local and regional policy and management serves as a reference. The projects studied show that the ES concept is seen as a tool for enhancing biodiversity, creating more sustainable regional development plans, supporting better spatial-planning decisions on soil sealing, and, most importantly, for getting the involvement of much broader stakeholder groups—not just to make better decisions, but also to attract more funding for the plans. Not only does the Netherlands have a high demand for various ecosystem services and a desire for multifunctional land use, it also has a long tradition of consensus-seeking. As a result, “Dutch practice” is complex and involves many different stakeholders. Because of increasing recognition of the role ecosystem services play in enhancing the visibility of natural resources in decision making, the ES concept seems to be gaining a foothold. However, the number of projects is still limited, and neither the use of the methods nor the results are monitored. So far, this has made it impossible to say whether the approach leads to more sustainable decisions—in other words, to the better protection and management of natural resources. Integr Environ Assess Manag 2013; 9: 237–242. © 2013 SETAC
A Spanish Version of the Sociocultural Attitudes Towards Appearance Questionnaire‐3 (SATAQ‐3): Translation and Psychometric Evaluation
Authors: Llorente Enrique , Warren Cortney S. , de Eulate Lourdes Pérez , Gleaves David H. 
Published: January 2013

ObjectiveThe goal of this study was to translate the Sociocultural Attitudes Towards Appearance Questionnaire‐3 (SATAQ‐3; Thompson, van den Berg, Roehrig, Guarda, & Heinberg, 2004) into Spanish and psychometrically evaluate the comparability of the Spanish translation to the original English version.Method638 female college students from Spain and the United States completed the SATAQ‐3 in Spanish and English, respectively.ResultsInternal consistency was high in both languages. Tests of factor equivalence suggested that the four pre‐established factors of the SATAQ‐3 (i.e., knowledge, perceived pressure, thin‐ideal internalization, athletic‐ideal internalization) were relatively similar between the two groups. Differences that emerged between groups (on items 6 and 20) were in the expected direction and appeared to be influenced by reverse‐scoring or item wording.ConclusionsResults support the psychometric properties of this Spanish translation of the SATAQ‐3 and support its use to measure endorsement of Western values and ideals of appearance in adult women.
In vivo gene transfer using pDNA/chitosan/chondroitin sulfate ternary complexes: influence of chondroitin sulfate on the stability of freeze‐dried complexes and transgene expression in vivo
Authors: Hagiwara Kenji , Kishimoto Satoko , Ishihara Masayuki , Koyama Yoshiyuki , Mazda Osam , Sato Toshinori 
Published: January 2013

AbstractBackgroundChitosan has been investigated as a promising nonviral vector. However, several problems still remain, such as a relatively low transfection efficiency and instability under physiological conditions. We previously demonstrated that a chondroitin sulfate (CS) coating enhanced the transfection efficiency and physicochemical stability of plasmid DNA (pDNA)/chitosan complexes in vitro. In the present study, the effects of coating pDNA/chitosan complexes with CS on the stability in freeze–dry rehydration processes and gene expression in vivo were investigated.MethodsFreeze‐drying storage at –20 °C, 4 °C, or room temperature, freezing storage at –20 °C, or liquid storage at 4 °C or room temperature, were examined for preservation conditions of pDNA/chitosan/CS ternary complexes by a gel retardation assay, measurements of sizes and zeta potentials, and a luciferase assay. Moreover, to determine the transfection efficiency of the ternary complexes in vivo, suicide gene therapy was carried out in Huh‐7‐implanted mice using herpes simplex virus thymidine kinase coding pDNA and ganciclovir.ResultsThe freeze‐dried pDNA/chitosan/CS ternary complexes showed sufficient cell transfection ability in vitro and in vivo. In addition, ternary complexes were associated with a significant suppression of tumor growth and a histopathologically high anti‐tumor effect by intratumoral injection to tumor‐bearing mice.ConclusionsThe CS coating enhanced the preservation stability of the pDNA/chitosan complexes after freeze‐drying–rehydration and their transgene expression in vivo. Copyright © 2013 John Wiley & Sons, Ltd.
Does Innovativeness Drive Environmentally Conscious Consumer Behavior?
Authors: Englis Basil G. , Phillips Diane M. 
Published: January 2013

ABSTRACTThis study seeks to improve the predictive utility of the attitude–behavior link within the realm of environmentally responsible consumption by examining the role of consumer innovativeness as a mediator. A sample of over 1400 American consumers provided data regarding their attitudes about the environment, receptiveness to new and innovative ideas, propensity to adopt new products early, and likelihood of performing a variety of green behaviors. The evidence suggests that one dimension of consumer innovativeness mediates the link between environmentally conscious attitudes and behaviors: the general affinity for new ideas. Managerial implications of these findings are discussed.
The Marketers’ Prismatic Palette: A Review of Color Research and Future Directions
Authors: Labrecque Lauren I. , Patrick Vanessa M. , Milne George R. 
Published: January 2013

ABSTRACTColor carries meaning and can influence consumers’ thoughts, feelings, and behaviors. Many disciplines, such as neuroscience, psychophysics, visual cognition, and biology have used new technologies to gain insights in understanding the complexities of color perception, yet there exists relatively little research in the field of marketing. This paper aims to reestablish the importance of color research in marketing, draw attention to the complex nature of this research, and to fuel further investigation and the development of new insights about color as it relates to marketing. The authors offer an integrated conceptual framework centered on the embodied and referential meanings of color and highlight the complexities and nuances that researchers must consider in order to develop this area. Insights from and gaps in the extant literature are highlighted to present a set of questions and propositions for future research in this area of investigation.
Differential regulation of HIF‐mediated pathways increases mitochondrial metabolism and ATP production in hypoxic osteoclasts
Authors: Morten Karl J , Badder Luned , Knowles Helen J 
Published: January 2013

AbstractInappropriate osteoclast activity instigates pathological bone loss in rheumatoid arthritis. We have investigated how osteoclasts generate sufficient ATP for the energy‐intensive process of bone resorption in the hypoxic microenvironment associated with this rheumatic condition. We show that in human osteoclasts differentiated from CD14+ monocytes, hypoxia (24 h, 2% O2): (a) increases ATP production and mitochondrial electron transport chain activity (Alamar blue, O2 consumption); (b) increases glycolytic flux (glucose consumption, lactate production); and (c) increases glutamine consumption. We demonstrate that glucose, rather than glutamine, is necessary for the hypoxic increase in ATP production and also for cell survival in hypoxia. Using siRNA targeting specific isoforms of the hypoxia‐inducible transcription factor HIF (HIF‐1α, HIF‐2α), we show that employment of selected components of the HIF‐1α‐mediated metabolic switch to anaerobic respiration enables osteoclasts to rapidly increase ATP production in hypoxia, while at the same time compromising long‐term survival. We propose this atypical HIF‐driven metabolic pathway to be an adaptive mechanism to permit rapid bone resorption in the short term while ensuring curtailment of the process in the absence of re‐oxygenation. Copyright © 2013 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Evaluation of Dosing and Clinical Outcomes in Patients Undergoing Conversion of Insulin Glargine to Insulin Detemir
Authors: Bryant Ginelle A. , McDanel Deanna L. , Horner Kathleen E. , Farris Karen B. , Newkirk Erin N. 
Published: January 2013

Study ObjectivesTo evaluate the dose and frequency of insulin detemir for patients with diabetes mellitus undergoing conversion from insulin glargine to insulin detemir, and to assess glycemic control, weight gain, and risk of hypoglycemia after converting to insulin detemir.DesignRetrospective medical record review.SettingLarge academic medical center.PatientsThirty‐one patients with type 1 (10 patients) or type 2 (21 patients) diabetes who were converted from insulin glargine to insulin detemir by usual practice between January 1, 2006, and March 3, 2007, after an Iowa Medicaid formulary switch.Measurement and Main ResultsData were collected for 12 months after conversion from insulin glargine to insulin detemir. No significant change in mean basal insulin dose was noted in patients with type 1 diabetes at the end of 12 months (insulin detemir 31.1 units/day vs baseline insulin glargine 32.0 units/day, p=0.89; insulin detemir 0.41 unit/kg/day vs baseline insulin glargine 0.42 unit/kg/day, p=0.91). In patients with type 2 diabetes, however, the mean basal insulin dose was significantly higher with insulin detemir compared with baseline insulin glargine (74.2 vs 55.8 units/day, p=0.002; 0.68 vs 0.48 unit/kg/day, p=0.001) at the end of 12 months. Twice‐daily administration was required in a higher proportion of patients receiving insulin detemir (15 patients [48%]) at 12 months compared with insulin glargine (4 patients [13%]) at baseline (p=0.043). A significant change in hemoglobin A1c was not observed in patients with type 1 diabetes (9.7% with insulin detemir vs 9.3% with insulin glargine, p=0.41) or type 2 diabetes (9.4% with insulin detemir vs 9.7% with insulin glargine at baseline, p=0.57) despite the use of higher insulin detemir doses in patients with type 2 diabetes. No significant differences in weight or frequency of hypoglycemia were noted.ConclusionTreatment with insulin detemir appears to require more frequent administration and higher insulin doses compared with insulin glargine in patients with type 2 diabetes, with 33% higher doses, on average, observed in this study. These findings suggest that a unit‐for‐unit conversion from insulin glargine to insulin detemir, as suggested by the manufacturer of insulin detemir, may not be adequate in patients with type 2 diabetes.
In situ Cu(0)‐mediated single electron transfer living radical polymerization of methyl methacrylate using nickel powder
Authors: Liu Xiao‐Hui , Yu Yun‐Hai , Jia Di , Cheng Bo‐Wen , Zhang Fei‐Jun , Li Hui‐Na , Chen Peng , Xie Shan 
Published: January 2013

AbstractSingle electron transfer living radical polymerization of methyl methacrylate catalyzed by the in situ prepared Cu(0) at ambient temperature was first examined using various metallic powders, including Zn(0), Ni(0), Mg(0), and Fe(0). Importantly, the polymerization initiated with Ni(0)/EBiB/CuBr2/PMDETA system exhibited optimal living/controlled nature and generated polymers with polydispersity index as low as 1.04 for 75.27% conversion and controlled molecular weights close to theoretical ones. A wide of range of Cu(II) salts were also investigated as catalyst sources instead of CuBr2. The recycling of Ni(0) was very convenient due to its magnetic property, which enables its extensive application. © 2013 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2013
Meta‐analysis of randomised trials with a continuous outcome according to baseline imbalance and availability of individual participant data
Authors: Riley Richard D. , Kauser Iram , Bland Martin , Thijs Lutgarde , Staessen Jan A. , Wang Jiguang , Gueyffier Francois , Deeks Jonathan J. 
Published: January 2013

We describe methods for meta‐analysis of randomised trials where a continuous outcome is of interest, such as blood pressure, recorded at both baseline (pre treatment) and follow‐up (post treatment). We used four examples for illustration, covering situations with and without individual participant data (IPD) and with and without baseline imbalance between treatment groups in each trial.Given IPD, meta‐analysts can choose to synthesise treatment effect estimates derived using analysis of covariance (ANCOVA), a regression of just final scores, or a regression of the change scores. When there is baseline balance in each trial, treatment effect estimates derived using ANCOVA are more precise and thus preferred. However, we show that meta‐analysis results for the summary treatment effect are similar regardless of the approach taken. Thus, without IPD, if trials are balanced, reviewers can happily utilise treatment effect estimates derived from any of the approaches.However, when some trials have baseline imbalance, meta‐analysts should use treatment effect estimates derived from ANCOVA, as this adjusts for imbalance and accounts for the correlation between baseline and follow‐up; we show that the other approaches can give substantially different meta‐analysis results. Without IPD and with unavailable ANCOVA estimates, reviewers should limit meta‐analyses to those trials with baseline balance. Trowman's method to adjust for baseline imbalance without IPD performs poorly in our examples and so is not recommended.Finally, we extend the ANCOVA model to estimate the interaction between treatment effect and baseline values and compare options for estimating this interaction given only aggregate data. Copyright © 2013 John Wiley & Sons, Ltd.
Multistage Vectored siRNA Targeting Ataxia‐Telangiectasia Mutated for Breast Cancer Therapy
Authors: Xu Rong , Huang Yi , Mai Junhua , Zhang Guodong , Guo Xiaojing , Xia Xiaojun , Koay Eugene J. , Qin Guoting , Erm Donald R. , Li Qingpo , Liu Xuewu , Ferrari Mauro , Shen Haifa 
Published: January 2013

AbstractThe ataxia‐telangiectasia mutated (ATM) protein plays a central role in DNA damage response and cell cycle checkpoints, and may be a promising target for cancer therapy if normal tissue toxicity could be avoided. The strategy presented here to target ATM for breast cancer therapy involves the use of liposomal‐encapsulated, gene‐specific ATM siRNA delivered with a well‐characterized porous silicon‐based multistage vector (MSV) delivery system (MSV/ATM). Biweekly treatment of MSV/ATM suppressed ATM expression in tumor tissues, and consequently inhibited growth of MDA‐MB‐231 orthotopic tumor in nude mice. At the therapeutic dosage, neither free liposomal ATM siRNA nor MSV/ATM triggered an acute immune response in BALB/c mice, including changes in serum cytokines, chemokines or colony‐stimulating factors. Weekly treatments of mice with free liposomal ATM siRNA or MSV/ATM for 4 weeks did not cause significant changes in body weight, hematology, blood biochemistry, or major organ histology. These results indicate that MSV/ATM is biocompatible and efficacious in inhibiting tumor growth, and that further preclinical evaluation is warranted for the development of MSV/ATM as a potential therapeutic agent.
Targeted Delivery of siRNA‐Generating DNA Nanocassettes Using Multifunctional Nanoparticles
Authors: Cho Young‐Seok , Lee Gee Young , Sajja Hari Krishna , Qian Weiping , Cao Zehong , He Weiling , Karna Prasanthi , Chen Xiaoyuan , Mao Hui , Wang Y. Andrew , Yang Lily 
Published: January 2013

AbstractMolecular therapy using a small interfering RNA (siRNA) has shown promise in the development of novel therapeutics. Various formulations have been used for in vivo delivery of siRNAs. However, the stability of short double‐stranded RNA molecules in the blood and efficiency of siRNA delivery into target organs or tissues following systemic administration have been the major issues that limit applications of siRNA in human patients. In this study, multifunctional siRNA delivery nanoparticles are developed that combine imaging capability of nanoparticles with urokinase plasminogen activator receptor‐targeted delivery of siRNA expressing DNA nanocassettes. This theranostic nanoparticle platform consists of a nanoparticle conjugated with targeting ligands and double‐stranded DNA nanocassettes containing a U6 promoter and a shRNA gene for in vivo siRNA expression. Targeted delivery and gene silencing efficiency of firefly luciferase siRNA nanogenerators are demonstrated in tumor cells and in animal tumor models. Delivery of survivin siRNA expressing nanocassettes into tumor cells induces apoptotic cell death and sensitizes cells to chemotherapy drugs. The ability of expression of siRNAs from multiple nanocassettes conjugated to a single nanoparticle following receptor‐mediated internalization should enhance the therapeutic effect of the siRNA‐mediated cancer therapy.
Plasmon‐Mediated Synthesis of Silver Cubes with Unusual Twinning Structures Using Short Wavelength Excitation
Authors: Personick Michelle L. , Langille Mark R. , Zhang Jian , Wu Jinsong , Li Shuyou , Mirkin Chad A. 
Published: January 2013

AbstractThe plasmon‐mediated synthesis of silver nanoparticles is a versatile synthetic method which leverages the localized surface plasmon resonance (LSPR) of nanoscale silver to generate particles with non‐spherical shapes and control over dimensions. Herein, a method is reported for controlling the twinning structure of silver nanoparticles, and consequently their shape, via the plasmon‐mediated synthesis, solely by varying the excitation wavelength between 400, 450, and 500 nm, which modulates the rate of Ag+ reduction. Shorter, higher energy excitation wavelengths lead to faster rates of reaction, which in turn yield structures containing a greater number of twin boundaries. With this method, silver cubes can be synthesized using 450 nm excitation, which represents the first time this shape has been realized by a plasmon‐mediated synthetic approach. In addition, these cubes contain an unusual twinning structure composed of two intersecting twin boundaries or multiple parallel twin boundaries. With respect to their twinning structure, these cubes fall between planar‐twinned and multiply twinned nanoparticles, which are synthesized using 500 and 400 nm excitation, respectively.
Polyethylene Glycol and Polyethylenimine Dual‐Functionalized Nano‐Graphene Oxide for Photothermally Enhanced Gene Delivery
Authors: Feng Liangzhu , Yang Xianzhu , Shi Xiaoze , Tan Xiaofang , Peng Rui , Wang Jun , Liu Zhuang 
Published: January 2013

AbstractGraphene oxide (GO) has been extensively explored in nanomedicine for its excellent physiochemical, electrical, and optical properties. Here, polyethylene glycol (PEG) and polyethylenimine (PEI) are covalently conjugated to GO via amide bonds, obtaining a physiologically stable dual‐polymer‐functionalized nano‐GO conjugate (NGO‐PEG‐PEI) with ultra‐small size. Compared with free PEI and the GO‐PEI conjugate without PEGylation, NGO‐PEG‐PEI shows superior gene transfection efficiency without serum interference, as well as reduced cytotoxicity. Utilizing the NIR optical absorbance of NGO, the cellular uptake of NGO‐PEG‐PEI is shown to be enhanced under a low power NIR laser irradiation, owing to the mild photothermal heating that increases the cell membrane permeability without significantly damaging cells. As the results, remarkably enhanced plasmid DNA transfection efficiencies induced by the NIR laser are achieved using NGO‐PEG‐PEI as the light‐responsive gene carrier. More importantly, it is shown that our NGO‐PEG‐PEI is able to deliver small interfering RNA (siRNA) into cells under the control of NIR light, resulting in obvious down‐regulation of the target gene, Polo‐like kinase 1 (Plk1), in the presence of laser irradiation. This study is the first to use photothermally enhanced intracellular trafficking of nanocarriers for light‐controllable gene delivery. This work also encourages further explorations of functionalized nano‐GO as a photocontrollable nanovector for combined photothermal and gene therapies.