bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polygenic risk score of metabolic dysfunction-associated steatotic liver disease amplifies the health impact on severe liver disease and metabolism-related outcomes
Authors: Xiao Lushan , Li Yan , Hong Chang , Ma Pengcheng , Zhu Hongbo , Cui Hao , Zou Xuejing , Wang Jiaren , Li Ruining , He Jingzhe , Liang Shengxing , Li Zeyang , Zeng Lin , Liu Li 
Published: July 2024

Abstract
Background
Although the inherited risk factors associated with fatty liver disease are well understood, little is known about the genetic background of metabolic dysfunction-associated steatotic liver disease (MASLD) and its related health impacts. Compared to non-alcoholic fatty liver disease (NAFLD), MASLD presents significantly distinct diagnostic criteria, and epidemiological and clinical features, but the related genetic variants are yet to be investigated. Therefore, we conducted this study to assess the genetic background of MASLD and interactions between MASLD-related genetic variants and metabolism-related outcomes.

Methods
Participants from the UK Biobank were grouped into discovery and replication cohorts for an MASLD genome-wide association study (GWAS), and base and target cohorts for polygenic risk score (PRS) analysis. Autosomal genetic variants associated with NAFLD were compared with the MASLD GWAS results. Kaplan–Meier and Cox regression analyses were used to assess associations between MASLD and metabolism-related outcomes.

Results
Sixteen single-nucleotide polymorphisms (SNPs) were identified at genome-wide significance levels for MASLD and duplicated in the replication cohort. Differences were found after comparing these SNPs with the results of NAFLD-related genetic variants. MASLD cases with high PRS had a multivariate-adjusted hazard ratio of 3.15 (95% confidence interval, 2.54–3.90) for severe liver disease (SLD), and 2.81 (2.60–3.03) for type 2 diabetes mellitus. The high PRS amplified the impact of MASLD on SLD and extrahepatic outcomes.

Conclusions
High PRS of MASLD GWAS amplified the impact of MASLD on SLD and metabolism-related outcomes, thereby refining the process of identification of individuals at high risk of MASLD. Supplementation of this process with relevant genetic backgrounds may lead to more effective MASLD prevention and management.
Shionone relieves oxygen-glucose deprivation/reoxygenation induced SH-SY5Y cells injury by inhibiting the p38 MAPK/NF-κB pathway
Authors: Zhou Xiaoli , Luo Xueting 
Published: July 2024

Abstract
Background
Cerebral ischemia-reperfusion injury (I/R) can affect patient outcomes and can even be life-threatening. This study aimed to explore the role of Shionone in cerebral I/R and reveal its mechanism of action through the cerebral I/R in vitro model.

Methods
SH-SY5Y cells were subjected to oxygen-glucose deprivation/reoxygenation (OGD/R) to induce cerebral I/R in vitro model. SH-SY5Y cells were treated with different concentrations of Shionone. Cell counting kit-8 and flow cytometry assays were used to detect cell viability and apoptosis levels. The levels of superoxide dismutase, catalase, and malondialdehyde were determined using their corresponding kits to examine the level of oxidative stress. The inflammation response was detected by IL-6, IL-1β, and TNF-α levels, using enzyme-linked-immunosorbent-assay. RT-qPCR was performed to measure the mRNA levels of p38 and NF-κB. Western blotting was used to quantify the apoptosis-related proteins and p38MAPK/NF-κB signaling pathway proteins.

Results
Shionone exhibited no toxic effects on SH-SY5Y cells. Shionone inhibited OGD/R-induced cell apoptosis, improved the inflammatory response caused by OGD/R, and reduced the level of oxidative stress in cells. Western blot assay results showed that Shionone alleviated OGD/R-induced injury by inhibiting the activity of the p38 MAPK/NF-κB signaling pathway. The p38/MAPK agonist P79350 reversed the beneficial effects of Shionone.

Conclusion
Shionone alleviates cerebral I/R and may thus be a novel therapeutic strategy for treating cerebral I/R.
Pharmacological activity and clinical application analysis of traditional Chinese medicine ginger from the perspective of one source and multiple substances
Authors: Zhang Cheng , Rao Anyang , Chen Cui , Li Yuqing , Tan Xiuchi , Long Jiaxin , Wang Xinyue , Cai Junjie , Huang Jiquan , Luo Hua , Li Chuwen , Dang Yuanye 
Published: July 2024

AbstractAll types of ginger have common fundamental components, although they possess distinct strengths and inclinations when it comes to effectiveness and medicinal applications. Fresh ginger possesses the ability to effectively stimulate movement within the body, alleviate the act of vomiting, induce sweating, and provide relief for external syndromes. Dried ginger possesses both defensive and stimulant characteristics, which effectively raise the internal temperature and enhance the Yang energy. Fresh ginger is more hydrating than dried ginger, highly skilled at heating the Middle-jiao, alleviating pain, halting bleeding, and managing diarrhea. Dried ginger possesses the ability to alleviate coldness when consumed in a heated form, as well as to alleviate diarrhea when consumed in a heated form. It thrives in warm conditions and has a tendency to revert back to its warm nature. The moisture content of baked ginger is inferior to that of dried ginger, but it is highly effective in alleviating pain, bleeding, and diarrhea by warming the Middle-jiao. Ginger charcoal and stir-fried charcoal, produced through carbonization, have excellent heat retention properties and are effective in warming meridians and stopping bleeding. The potency and ability to spread of roasted ginger is less intense compared to fresh ginger, and its moisture content is not as low as that of dried ginger. The medicinal characteristics of this substance are gentle, making it beneficial for alleviating vomiting in patients who are physically frail. Its primary mode of action is on the Middle-jiao. Nevertheless, the main chemical compositions of various traditional Chinese medicines are nearly identical due to their shared base element. Ginger, in particular, possesses a range of pharmacological activities including antioxidant, anti-inflammatory, anti-tumor, anti-bacterial, and anticoagulant properties. However, modern pharmacological research has not fully acknowledged the clinical medicinal value of ginger and consequently, fails to provide accurate guidance for clinical medication. This situation has a negative impact on the contemporary advancement of traditional Chinese medicine (TCM). The research on modernizing ginger is conducted by analyzing and considering the prospects. It is based on Traditional Chinese Medicine (TCM) theory and incorporates the comprehensive perspective of TCM philosophy. In order to modernize ginger, it is essential to have a proper knowledge of the concepts of “recognizing nature by efficacy, homology, and mutual expression of nature and efficacy” and “rationally utilizing modern drug research technology”. By applying these principles, we can construct a bridge towards the advancement of ginger.
Sow dimensions and loose-housed farrowing pen sizes on commercial piglet-producing farms in Sweden
Authors: Hannius Linda Marie Backeman , Endrésen Emelie , Carlzén Helena , Wallenbeck Anna , Westin Rebecka 
Published: July 2024

AbstractInternational interest in loose-housed farrowing is growing and there are ongoing discussions within the European Union (EU) on new legal requirements. However, there is a lack of empirical data on loose-housed farrowing pen sizes and sow dimensions in commercial production. The aim of this study was to map and describe sow size and loose-housing farrowing pen size on commercial piglet-producing farms in Sweden. The study included 146 sows and 51 pen types on 35 medium sized to large Swedish piglet-producing farms (ranging from 106 to 1300 sows in production). Sow length ranged from 129 to 238 cm (mean ± SD 191.3 ± 19.3 cm) and sow height from 74 to 133 cm (86.7 ± 7.7 cm). Floor space occupied by the sow when lying down (length x height) ranged from 1.0 to 3.2 m2 (1.7 ± 0.3 m2). Pen length ranged from 259 to 415 cm (315.1 ± 24.3 cm), pen width from 188 to 245 cm (207.0 ± 10.7 cm), total pen area from 5.7 to 8.9 m2 (6.5 ± 0.5 m2), piglet corner area from 0.5 to 1.8 m2 (1.1 ± 0.4 m2) and area available for the sow (total area - piglet corner area) from 3.9 to 6.4 m2 (5.4 ± 0.6 m2). These results show that there is substantial variation in sow, pen and piglet corner size on commercial piglet-producing farms in Sweden. This poses a risk of mismatches between sow and pen size (pens too short in relation to sow dimensions), especially for older sows. These findings are of practical significance for animal welfare and production and emphasise the importance of designing loose-housed pens adapted to future sow, litter and piglet size.
The role of upper airway ultrasonography in tracheal necrosis diagnosis: a case report
Authors: Fazlin Mohd Jailaini Mas , Jazman Che Rahim Mohd , Aireene Wan Ahmed Wan , Farid Abdull Wahab Shaik , Faisal Abdul Hamid Mohamed , Zara Mohammad Nasseri Fahrin 
Published: July 2024

Abstract
Background
Tracheal necrosis post endotracheal intubation is a rare life-threatening disease that can compromise airway patency. We demonstrated a novel usage of upper airway ultrasonography (USG) to diagnose tracheal necrosis.

Case presentation
A middle-aged smoking male presented with productive cough, noisy breathing and exertional dyspnea for 2 weeks. He was intubated one month prior due to a traumatic brain injury. Upper airway USG findings showed irregular air-mucosal interface (AMI) and comet tail artefacts over the 1st and 2nd tracheal ring. A direct laryngoscopy in the operating room showed thick mucopus inferior to the vocal cords, with necrotic tracheal cartilages and debris obstructing the airway. He was successfully treated with parenteral antibiotics, wound debridement and tracheostomy.

Conclusion
Our case highlights the first documented USG findings of tracheal necrosis. Upper airway USG serves as a potential diagnostic modality in managing the condition.
Influence of prediabetes on the prognosis of patients with myocardial infarction: a meta-analysis
Authors: Zeng Mengya , Sun Eyu , Zhu Li , Deng Lingzhi 
Published: July 2024

Abstract
Background
Previous studies evaluating the association between prediabetes the prognosis of patients with acute myocardial infarction (AMI) showed inconsistent results. The aim of the meta-analysis was to compare the long-term incidence of major adverse cardiovascular events (MACEs) between AMI patients with prediabetes and normoglycemia.

Methods
Relevant prospective cohort studies were obtained by searching Medline, Web of Science, and Embase databases. Only studies with follow-up duration of at least one year were included. A random-effects model was utilized to pool the results by incorporating the influence of heterogeneity.

Results
Twelve studies with 6972 patients with AMI were included. Among them, 2998 were with prediabetes and 3974 were with normoglycemia. During a mean follow-up of 52.6 months, 2100 patients developed MACEs. Compared to those with normoglycemia, AMI patients with prediabetes were associated with a higher incidence of MACEs (risk ratio [RR]: 1.30, 95% confidence interval: 1.07 to 1.58, p = 0.008; I2 = 67%). Subgroup analysis showed a stronger association between prediabetes and MACEs in studies of patients with mean age ≥ 60 years compared to < 60 years (RR: 1.66 versus 1.10, p for subgroup difference = 0.04), with proportion of men < 75% compared to ≥ 75% (RR: 1.87 versus 1.08, p for subgroup difference = 0.01), and in prediabetes evaluated at or after discharge compared to that evaluated within three days of AMI onset (RR: 1.39 versus 0.78, p for subgroup difference = 0.01).

Conclusions
Prediabetes may be associated with a higher risk of MACEs in patients with AMI.
Cardiac rehabilitation in children and adolescents with long QT syndrome: the RYTHMO’FIT pilot study
Authors: Souilla Luc , Guillaumont Sophie , Auer Annie , Metzler Gael , Requirand Anne , Vincenti Marie , De La Villeon Gregoire , Pasquie Jean-Luc , Mottet Denis , Amedro Pascal 
Published: July 2024

Abstract
Background
To assess the feasibility, acceptability, safety, and short-term benefits of a tailored cardiac rehabilitation program for children and adolescents with long QT syndrome (LQTS).

Methods
Eight participants, aged between 6 and 18, with a positive LQTS genotype and impaired cardiorespiratory fitness, were enrolled in a 12-week centre-based cardiac rehabilitation program. The program included supervised exercise training group sessions (aerobic, resistance, and outdoor activities) and patient education workshops. Feasibility, acceptability, and safety of the program were prospectively monitored. Feedback from the parents, children, and professionals involved was collected from qualitative interviews. Short-term effects on cardiorespiratory fitness, muscle fitness, physical activity, and health-related quality of life (HRQoL) were measured between baseline and the end of the program.

Results
Retention (88% with one participant dropping out) and adherence (79%) rates were good, and no cardiac events occurred during the 12-week intervention period. Participants, parents, and healthcare professionals expressed a high level of satisfaction with the program. A significant increase between the beginning and the end of the program was observed for ventilatory anaerobic threshold (21.7±5.2 vs. 28.7±5.1 mL/kg/min, P=0.01, effect size=0.89), grip strength, (18±5.3 Kg vs. 20±4.7 Kg, P=0.02, effect size=0.90), lower limb explosive strength (142±36.5 cm vs. 148±24 cm, P=0.02, effect size=0.90), and parent-reported physical health dimension of HRQoL (65.6±9.75 vs. 84.4±20.35, P=0.03, effect size=0.87).

Conclusions
A 12-week tailored centre-based cardiac rehabilitation program was feasible, acceptable, and safe for children with LQTS. Cardiac rehabilitation for children with LQTS presents a new approach aligned with secondary prevention in youth with cardiac diseases.

Trial registration
The trial was registered at Clinicaltrials.gov (NCT05964322, registration date: 27/07/2023).
Robust error-state Kalman-type filters for attitude estimation
Authors: Bellés Andrea , Medina Daniel , Chauchat Paul , Labsir Samy , Vilà-Valls Jordi 
Published: July 2024

AbstractState estimation techniques appear in a plethora of engineering fields, in particular for the attitude estimation application of interest in this contribution. A number of filters have been devised for this problem, in particular Kalman-type ones, but in their standard form they are known to be fragile against outliers. In this work, we focus on error-state filters, designed for states living on a manifold, here unit-norm quaternions. We propose extensions based on robust statistics, leading to two robust M-type filters able to tackle outliers either in the measurements, in the system dynamics or in both cases. The performance and robustness of these filters is explored in a numerical experiment. We first assess the outlier ratio that they manage to mitigate, and second the type of dynamics outliers that they can detect, showing that the filter performance depends on the measurements’ properties.
Healthcare delivery to patients from culturally and linguistically diverse backgrounds in emergency care: a scoping review protocol
Authors: Huang Ya-Ling , Thorning Sarah , Lin Chun-Chih , Lee Robert , Elder Elizabeth , Crilly Julia 
Published: July 2024

Abstract
Background
Worldwide, the culturally and linguistically diverse (CALD) population is increasing, and is predicted to reach 405 million by 2050. The delivery of emergency care for the CALD population can be complex due to cultural, social, and language factors. The extent to which cultural, social, and contextual factors influence care delivery to patients from CALD backgrounds throughout their emergency care journey is unclear. Using a systematic approach, this review aims to map the existing evidence regarding emergency healthcare delivery for patients from CALD backgrounds and uses a social ecological framework to provide a broader perspective on cultural, social, and contextual influence on emergency care delivery.

Methods
The Joanna Briggs Institute (JBI) scoping review methodology will be used to guide this review. The population is patients from CALD backgrounds who received care and emergency care clinicians who provided direct care. The concept is healthcare delivery to patients from CALD backgrounds. The context is emergency care. This review will include quantitative, qualitative, and mixed-methods studies published in English from January 1, 2012, onwards. Searches will be conducted in the databases of CINAHL (EBSCO), MEDLINE (Ovid), Embase (Elsevier), SocINDEX (EBSCO), Scopus (Elsevier), and a web search of Google Scholar. A PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram will be used to present the search decision process. All included articles will be appraised using the Mixed Methods Appraisal Tool (MMAT). Data will be presented in tabular form and accompanied by a narrative synthesis of the literature.

Discussion
Despite the increased use of emergency care service by patients from CALD backgrounds, there has been no comprehensive review of healthcare delivery to patients from CALD backgrounds in the emergency care context (ED and prehospital settings) that includes consideration of cultural, social, and contextual influences. The results of this scoping review may be used to inform future research and strategies that aim to enhance care delivery and experiences for people from CALD backgrounds who require emergency care.

Systematic review registration
This scoping review has been registered in the Open Science Framework https://doi.org/10.17605/OSF.IO/HTMKQ
The cereal network: a baseline approach to current configurations of trade communities
Authors: Robu Raluca Georgiana , Alexoaei Alina Petronela , Cojanu Valentin , Miron Dumitru 
Published: July 2024

AbstractThis paper attempts to provide insights into the current network configurations of the food-trade system and to study the short-term effects of one of the ongoing and lasting global crises, the Ukraine War, on the link intensity. Towards this end, this analysis (1) reveals the pattern of countries’ network positions in two most traded subcategories of the cereal network: wheat and meslin, and maize or corn, and (2) discusses the characteristics of the global cereal networks over the 2021–2022 period. The results highlight several features of the trade networks: (1) the distribution of cereal trade is highly concentrated, with considerable dependency on a small number of exporters and a low import diversification, making the system rigid and prone to shocks; (2) a central role of several key developed countries that leave many developing countries outside the centre of the networks; (3) a high network heterogeneity which confirms the propensity to have hub nodes. Particular indicators show that the highest level of interconnectivity is specific to the cereals’ export network, the densest networks are the maize or corn ones, and the greatest heterogeneity appears for the cereals export network.
Sustainability challenges in the multi-tier crop agri-food sector: a systematic review
Authors: Khan Muhammad , Papadas Dimitrios , Arnold Lydia , Behrendt Karl 
Published: July 2024

AbstractThis systematic review identifies the potential sustainability challenges lower-tier suppliers and buying firms face in multi-tier crop agri-food supply chains. The first stage applied systematic mapping, and based on a sample of 487 academic articles from 6 databases, identified a less-researched area through empirical analysis. Secondly, a systematic evidence review synthesis methodology was used to synthesise the identified sustainability challenges from 18 qualitative studies focusing on the crop agri-food sector. A complex adaptive system, triple-bottom-line approach, and environmental, social, and governance sustainability models were applied to understand the nature of multi-tier supply chain structures and then identify sustainability challenges. Four major dimensions of sustainability challenges (social, economic, environmental and governance) for the lower-tier suppliers and buying firms were identified. Disintegration between buying firms and the lower-tier suppliers, predominantly due to their different locations, was found to be the primary reason for sustainability challenges in the crop agri-food sector. The review findings establish a theoretical framework that could serve as a roadmap for future research in multi-tier supply chains across various sectors and geographies, examining potential sustainability challenges and developing governance structures for sustainable development.
Lysine 2-hydroxyisobutyrylation levels determined adipogenesis and fat accumulation in adipose tissue in pigs
Authors: Yan Enfa , Tan Mingyang , Jiao Ning , He Linjuan , Wan Boyang , Zhang Xin , Yin Jingdong 
Published: July 2024

Abstract
Background
Excessive backfat deposition lowering carcass grade is a major concern in the pig industry, especially in most breeds of obese type pigs. The mechanisms involved in adipogenesis and fat accumulation in pigs remain unclear. Lysine 2-hydroxyisobutyrylation (Khib), is a novel protein post-translational modification (PTM), which play an important role in transcription, energy metabolism and metastasis of cancer cells, but its role in adipogenesis and fat accumulation has not been shown.

Results
In this study, we first analyzed the modification levels of acetylation (Kac), Khib, crotonylation (Kcr) and succinylation (Ksu) of fibro-adipogenic progenitors (FAPs), myogenic precursors (Myo) and mesenchymal stem cells (MSCs) with varied differentiation potential, and found that only Khib modification in FAPs was significantly higher than that in MSCs. Consistently, in parallel with its regulatory enzymes lysine acetyltransferase 5 (KAT5) and histone deacetylase 2 (HDAC2) protein levels, the Khib levels increased quadratically (P < 0.01) during adipogenic differentiation of FAPs. KAT5 knockdown in FAPs inhibited adipogenic differentiation, while HDAC2 knockdown enhanced adipogenic differentiation. We also demonstrated that Khib modification favored to adipogenic differentiation and fat accumulation by comparing Khib levels in FAPs and backfat tissues both derived from obese-type pigs (Laiwu pigs) and lean-type pigs (Duroc pigs), respectively. Accordingly, the expression patterns of KAT5 and HDAC2 matched well to the degree of backfat accumulation in obese- and lean-type pigs.

Conclusions
From the perspective of protein translational modification, we are the first to reveal the role of Khib in adipogenesis and fat deposition in pigs, and provided new clues for the improvement of fat accumulation and distribution as expected via genetic selection and nutritional strategy in obese-type pigs.