bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mir-15A Reconstitution in Prostate Cancer Cell Line Suppresses Cancer Progression Through Down Regulation of MYB and Androgen Receptor Upregulation
Authors: Todorova K. , Hayrabedyan S. 
Published: May 2015

Summary
Prostate cancer is one of the most common malignancies and the second leading cause of death from cancer in men. MicroRNAs are noncoding RNAs that have a role of post-transcriptional regulators. In this study we investigated how the tumour suppressor miR-15a modulates main transcription factors like cMYB and AR in androgen sensitive prostate cancer cell line LNCaP. The miR-15a inhibitor, mimic, and their negative controls were transfected into LNCaP cells. Real-time PCR analysis was performed in order to estimate the transcript levels of cMYB and AR. Flow cytometry analysis was performed to measure the protein levels of cMYB and AR. A Cell migration assay was done for cells transfected with miR-15a inhibitor and mimic. We found that cMYB is down-regulated and AR is up-regulated by miR-15a on the transcriptional and protein levels. By reconstituting miR-15a, we found that its down regulation in prostate cancer contributes to cMYB-induced cancer progression and reduced androgen receptivity. The ability of miR-15a to suppress cancer cell viability and migration is a very important phenomenon for understanding cancer heterogeneity in regard to adapted therapeutic approach development.
The Adverse Health Effects of Shift Work in Relation to Risk of Illness/Disease: A Review
Authors: Shariat A. , Bahri Mohd Tamrin Sh. , Daneshjoo A. , Sadeghi H. 
Published: May 2015

Summary
Biological rhythm of sleeping is a natural disparity in an organism corresponding to and in reply to cyclic environmental changes, such as daylight hours and hours of darkness or elevated and low down flow. There is some evidence, based upon epidemiological studies as well as studies upon smaller groups of subjects, that individuals who work during the night and sleep during the daytime show cognitive impairment at work, have poorer and fragmented daytime sleep, and have increased risks of developing a wide range of social, psychological, physiological and medical impairments and disorders. Circadian rhythms are one of the most important effective factors on the physiological and physical performances of humans and disturbing this normal rhythm leads to different groups of diseases. The majority of investigations in biological rhythm demeanor vary noticeably in regards to the exact type of disease, population and protocols of sampling over the other outcomes or issues. We conducted a systematic review of [Science Direct, Pubmed, Scopus] to identify influence of different kinds of diseases among shift workers in response to abnormal rhythm of sleeping. The results of this review indicate that abnormal patterns of sleeping can lead to immunological issues, hypertension, metabolic syndrome, insomnia, cardiovascular disease, obesity and depression. It is vital for subsequent investigations to find a way to reduce negative effects (such as decreased amount of works’ time and altered diet) without side effects to help them.
Noun Cases of Hungarian Language in Romanian
Authors: Both Csaba Attila 
Published: May 2015

Abstract
In the present-day discourse of bilingualism in Transylvania, the investigation of methods and possibilities for language teaching has an important role. In Romania, it is compulsory for the members of linguistic minorities to learn and to use the language of the state, but at the same time they face a number of problems in the process of learning it. To reconsider the methods of language teaching, there is need for studies which outline the particularities of language use of Romanian of Hungarian speakers. This paper is aimed at presenting a part of this image by analysing how the Hungarian language and the cognitive features entailed influence the translation of noun cases into the Romanian language. The paper presents the 18 noun cases and the prepositions they can be translated with into Romanian.
Applied Drama and Theatre – Drama Techniques in Teaching English for Specific Purposes
Authors: Kovács Gabriella 
Published: May 2015

Abstract
Theatre is a source to which teachers often turn for fresh ideas and methods. This study tries to unfold and follow the path which leads from theatre and drama to institutional education, and reveal the complex interdisciplinary connections and relations which have made it possible to use some of the experiences and methods accumulated in the field of actor training and applied drama and theatre in teaching English for specific purposes.
Männergestalten in Martin Walsers Ein fliehendes Pferd
Authors: Nagy Szilveszter Orsolya 
Published: May 2015

Abstrakt
Martin Walsers Novelle Ein fliehendes Pferd ist Psychogramm und Gesellschaftsanalyse zugleich; Themen wie Diskrepanz von Lebensplan, gespielte Rollen und Alltagsrealität, sowie der Verlust des Ichs, die Suche nach der eigenen Identität, Beziehungsarmut, Produktion von Schein, Lebenssterilität und der Mangel an wahrer Kommunikation werden durch die Gestalten der Novelle projiziert. Die Viererkonstellation der Novelle zeigt eine starke Polarität der Männergestalten, die aber tief von einem gemeinsamen Fluchtzwang geprägt ist. Die grundlegende Zielsetzung des Artikels ist die Problematik der Charaktergestaltung unter die Lupe zu nehmen, sodass der Fokus an das schachspielartige Verhältnis von Helmut und Klaus gesetzt wird.
Die Rolle der Prestige im Sprachkontakt
Authors: Kelemen Attila 
Published: May 2015

Abstrakt
Die vorliegende Arbeit behandelt die Rolle des äuβeren Faktors „Prestige“ im Kontakt zwischen Sprachen, die Art und Weise, wie das Ansehen, das Dominanzverhältnis die Entfaltung und die Richtung des Entlehnungsprozesses, sowie das Überleben gewisser Wörter und Strukturen und sogar das Schicksal einer Sprache entscheiden.
Small-scale genetic structure of Gracilaria salicornia and its red algal parasite, G. babae (Gracilariaceae, Rhodophyta), in Malaysia
Authors: Ng Poh-Kheng , Lim Phaik-Eem , Phang Siew-Moi 
Published: May 2015

Abstract
The present study compares genetic structure from the plastid rbcL, mitochondrial cox1, and nuclear internal transcribed spacer (ITS) sequences among 13 populations of Gracilaria salicornia and its red algal parasite, G.
babae, in Malaysia. Owing to the unique biology of the red algal parasite, identical phylogeographies were inferred from the rbcL and cox1 sequences in both G. babae and its host, G. salicornia. Despite the low genetic variation, rbcL and cox1 showed a concordant phylogeographic split that largely corresponds to Peninsular Malaysia and East Malaysia, except for a sample from East Malaysia that was consistently grouped with samples from the peninsula. On the other hand, G. salicornia was separated from G. babae in the midpoint-rooted phylogeny inferred from ITS data despite the failure to retrieve the two taxa in reciprocal monophyly. Gracilaria
salicornia was less diverse and lacked apparent geographic structure. In contrast, the ITS data revealed considerable genetic diversity and fine-scale genetic structuring in G. babae within Malaysian waters, probably as a result of adaptation to the local host population.
Development and function of plasmodesmata in zygotes of Fucus distichus
Authors: Nagasato Chikako , Terauchi Makoto , Tanaka Atsuko , Motomura Taizo 
Published: May 2015

Abstract
Brown algae have plasmodesmata, tiny tubular cytoplasmic channels connecting adjacent cells. The lumen of plasmodesmata is 10–20 nm wide, and it takes a simple form, without a desmotubule (the inner membrane structure consisting of endoplasmic reticulum in the plasmodesmata of green plants). In this study, we analyzed the ultrastructure and distribution of plasmodesmata during development of Fucus distichus zygotes. The first cytokinesis of zygotes in brown algae is not accompanied by plasmodesmata formation. As the germlings develop, plasmodesmata are found in all septal cell walls, including the first cell division plane. Plasmodesmata are formed de novo on the existing cell wall. Pit fields, which are clusters of plasmodesmata, were observed in germlings with differentiated cell layers. Apart from the normal plasmodesmata, these pit fields had branched plasmodesmata that appeared to arise from the lateral preexisting ones. Fluorescent tracers with different molecular sizes were microinjected to examine the size exclusion limit of molecules for transit through the plasmodesmata. Fluorescein isothiocyanate (FITC)-dextran of 3 kDa size was spread over the germlings, and 10 kDa FITC-dextran was tracked only in the rhizoid. The size exclusion limit was <10 kDa for the thallus but <40 kDa for the rhizoid.
A Case Study of the English Teachers’ Burnout in a Medical University in China
Authors: Li Shunying 
Published: May 2015

AbstractMany College English teachers complain about work stress. To learn about the actual burnout situation and to seek intervention, a questionnaire survey and written interviews were conducted in a medical university in China. The results of the survey suggest that 29.73% of the participants experienced burnout. No significant differences were found in the aspects of the gender and educational background. However, older teachers experienced significantly more intense reduced personal accomplishment while more-experienced teachers reported significantly more intense depersonalization and reduced personal accomplishment. Similarly, participants with higher professional titles experienced much more intense depersonalization. Meanwhile, the results of the interviews indicate four causes of burnout: factors related to the job, students, management and teacher development. Internal and external moderations are categorized as the burnout reducers. As for intervention, teachers and the organization should work together to reduce the burnout syndrome.
Ferulates and lignin structural composition in cork
Authors: Marques António Velez , Rencoret Jorge , Gutiérrez Ana , del Río José C. , Pereira Helena 
Published: May 2015

AbstractThe structure of lignin and suberin, and ferulic acid (FA) content in cork fromQuercus suberL. were studied. Extractive-free cork (Cork), suberin, desuberized cork (Corksap), and milled-cork lignins (MCL) from Cork and Corksapwere isolated. Suberin composition was determined by GC-MS/FID, whereas the polymers structure in Cork, Corksap, and MCL was studied by Py-TMAH and 2D-HSQC-NMR. Suberin contained 94.4% of aliphatics and 3.2% of phenolics, with 90% of ω-hydroxyacids and α,ω-diacids. FA represented 2.7% of the suberin monomers, overwhelmingly esterified to the cork matrix. Py-TMAH revealed significant FA amounts in all samples, with about 3% and 6% in cork and cork lignins, respectively. Py-TMAH and 2D-HSQC-NMR demonstrated that cork lignin is a G-lignin (>96% G units), with a structure dominated by β–O–4′ alkyl-aryl ether linkages (80% and 77% of all linkages in MCL and MCLsap, respectively), followed by phenylcoumarans (18% and 20% in MCL and MCLsap, respectively), and smaller amounts of resinols (ca. 2%) and dibenzodioxocins (1%). HSQC also revealed that cork lignin is heavily acylated (ca. 50%) exclusively at the side-chain γ-position. Ferulates possibly have an important function in the chemical assembly of cork cell walls with a cross-linking role between suberin, lignin and carbohydrates.
Comprehensive Smart Grid Planning in a Regulated Utility Environment
Authors: Turner Matthew , Liao Yuan , Du Yan 
Published: May 2015

Abstract
This paper presents the tools and exercises used during the Kentucky Smart Grid Roadmap Initiative in a collaborative electric grid planning process involving state regulators, public utilities, academic institutions, and private interest groups. The mandate of the initiative was to assess the existing condition of smart grid deployments in Kentucky, to enhance understanding of smart grid concepts by stakeholders, and to develop a roadmap for the deployment of smart grid technologies by the jurisdictional utilities of Kentucky. Through involvement of many important stakeholder groups, the resultant Smart Grid Deployment Roadmap proposes an aggressive yet achievable strategy and timetable designed to promote enhanced availability, security, efficiency, reliability, affordability, sustainability and safety of the electricity supply throughout the state while maintaining Kentucky’s nationally competitive electricity rates. The models and methods developed for this exercise can be utilized as a systematic process for the planning of coordinated smart grid deployments.
Comparison of Artificial Neural Network and Response Surface Methodology Performance on Fermentation Parameters Optimization of Bioconversion of Cashew Apple Juice to Gluconic Acid
Authors: Osunkanmibi Omotola B. , Owolabi Temitayo O. , Betiku Eriola 
Published: May 2015

Abstract
The study examined the impact and interactions of cashew apple juice (CAJ) concentration, pH, NaNO3 concentration, inoculum size and time on gluconic acid (GA) production in a central composite design (CCD). The fermentation process and parameters involved were modeled and optimized using artificial neural network (ANN) and response surface methodology (RSM). The ANN model established the optimum levels as CAJ of 250 g/l, pH of 4.21, NaNO3 of 1.51 g/l, inoculum size of 2.87% volume and time of 24.41 h with an actual GA of 249.99 g/l. The optimum levels predicted by RSM model for the five independent variables were CAJ of 249 g/l, pH of 4.6, NaNO3 of 2.29 g/l, inoculum size of 3.95% volume, and time of 38.9 h with an actual GA of 246.34 g/l. The ANN model was superior to the RSM model in predicting GA production. The study demonstrated that CAJ could serve as the sole carbon source for GA production.
Meconium aspiration syndrome in infants of HIV-positive women: a case-control study
Authors: Gupta Sachin K. , Haerr Pam , David Richard , Rastogi Alok , Pyati Suma 
Published: May 2015

AbstractOur aim was to determine whether maternal HIV infection in the current era is associated with an increased incidence of meconium aspiration syndrome (MAS) in their infants.Infants born to 149 HIV-positive women at our hospital over a 5-year period were compared with infants born to HIV-negative women in a retrospective case-control study. Charts of all 298 patients included in the study were reviewed for maternal and infant demographics, HIV treatment, vertical transmission and untoward events at delivery or during the hospital course.When compared with HIV-negative women, a greater proportion of HIV-positive women had meconium-stained amniotic fluid (MSAF), 33% vs. 13%, P<0.001; and thick MSAF, 17% vs. 5%, P<0.001, respectively. Seven of 298 infants were admitted to the neonatal intensive care unit for MAS; all seven were born to HIV-positive women (P=0.015). AlthoughInfants born to HIV-positive women had significantly more MSAF and MAS than infants born to non-infected women. It is unclear whether this association results from maternal HIV infection itself or from anti-retroviral therapy. Maternal and infant care providers should be prepared for this complication when attending to the deliveries of HIV-positive women.
Signaling molecules from Lactuca sativa L. induced quorum sensing phenotypes in bacteria
Authors: Mahmoudi Esmaeil 
Published: May 2015

Abstract
The outcome of the present investigation revealed that lettuce (Lactuca sativa L.) extract strongly interferes with acyl homoserine lactone (AHL) regulated physiological functions in the bioreporter strain, Chromobacterium violaceum CV026. Extracts of L. sativa also promoted production of virulence factors in plant pathogen, Pectobacterium carotovorum, and significantly increased tissue maceration on potato tubers when there was a low concentration (103 cfu · ml−1) of the bacterium was used. The thin layer chromatogram which visualised with AHL bioreporter strain, CV026, showed that L. sativa extract produced a circular spot with a diffuse edge tail and migrated with the same mobility as standard N-hexanoyl-L-homoserine lactone (C6-HSL). Gas Chromatography Mass Spectroscopy (GC-MS) analysis of the lettuce extract resulted in the identification of 19 compounds of which homoserine was identified for the first time in plants. Homoserine accounted for 2.37% of the total constituents. It is a new finding that lettuce contains AHL like substances (homoserine) which excite AHL related quorum sensing (QS) in bacteria.
High prevalence of severe vitamin D deficiency in patients with acute myocardial infarction
Authors: Yilmaz Akar , Eren Esin , Ellidag Hamit Yasar , Yuksel Isa Oner , Yilmaz Necat , Arslan Sakir , Aydin Ozgur 
Published: May 2015

Abstract

Background: Vitamin D deficiency is associated with acute coronary syndrome (ACS). We aimed to evaluate calcidiol status and its relationship with coronary angiography findings in two selected groups of ACS patients.

Methods: We investigated two groups of patients with ACS: 75 patients with ST-segment-elevation myocardial infarction (STEMI) and 68 patients with unstable angina pectoris (USAP). The ACS diagnosis was confirmed by coronary angiography findings. Biochemical parameters were studied at the first visit of the patients with automated instruments and ready-to-use kits.

Results: Calcidiol levels were significantly lower in the STEMI group compared to the USAP group (p<0.001), while the prevalence of calcidiol deficiency in the STEMI group was significantly higher (p<0.001). Serious calcidiol deficiency (<4 ng/mL) was present in 17% of the STEMI group and in 7% of the USAP group. We did not observe any significant relationship between calcidiol status and coronary angiography findings.

Conclusions: Our results support the previously described associations between ACS and calcidiol deficiency. Besides, we report a more severe calcidiol deficiency and an extraordinarily high prevalence of vitamin D deficiency or insufficiency in these patients.
La villa romana di San Potito, ultimi risultati delle ricerche
Authors: Redő Ferenc 
Published: May 2015

During the last years, the excavation mostly focused on the SE part of the villa. This territory was inhabited or even densely built in all through the existence of the villa. We could more precisely determine the chronology and periodisation of the entire site, which also included the publication and evaluation of the complete coin material of the site.
In the second part of the study, we examine a building of the villa that has been known for decades without being able to determine its function and role. We have already published its details and 3D reconstruction but it has not provoked substantial reaction. Its shape, structure and position within the villa complex and its wider geographical environment suggest that it could be a cold storage, an ice house. This type of building is barely known until the Modern Period. The shape of this building is not typical since was constructed with a different purpose and was only later modified to fit this function. The subterranean part of its structure afforded the observation of minute details. In this study we intend to present our hypothesis.
Parides burchellanus (Westwood, 1872) (Lepidoptera, Papilionidae): new distribution records from southwestern Minas Gerais state, Brazil
Authors: Bedê Lúcio Cadaval , Marini-Filho Onildo João , Neto Fernando Correa Campos , Ribeiro Flávia , Reis Edmar Simões dos , Beirão Marina Do Vale , Resende Felipe Oliveira 
Published: May 2015

We herein report new records of Parides burchellanus (Westwood, 1872) in southwestern Minas Gerais state, Brazil, in areas of the upper São Francisco and Araguari river systems, including the buffer zone of the Parque Nacional da Serra da Canastra. Until recently, the only known colonies of P. burchellanus were located in the municipalities of Brumadinho, in Minas Gerais state, and Planaltina, in the Distrito Federal, some 640 km apart from each other. The implications of these new records to the conservation status of this species are discussed.
Morphological Change of a PbSe film grown by Chemical Bath Deposition during Sensitization
Authors: Suh Youngjoon , Suh Sang Hee 
Published: May 2015

ABSTRACTA PbSe film was grown by chemical bath deposition on a thermally oxidized Si (111) substrate. Morphological change of the PbSe film during sensitization under the oxygen and iodine atmospheres was studied by SEM. The as-grown polycrystalline PbSe film consists of clusters of about 200nm in diameter. By the oxidation treatment for 30 min at 380°C, the clusters became joined together. On the other hand, recrystallization of new PbSe crystals with faceted surfaces occurred during the iodination treatment under an iodine plus nitrogen atmosphere at 380°C for different durations. This morphological change during the sensitization treatment might affect the electro-optical properties of the PbSe film.
The advancement of medical education through innovative research and simulation learning: A discussion with Dr. Viren Naik, medical director of the University of Ottawa’s Skills and Simulation Centre
Authors: Cheung Loretta , Noel Ariana 
Published: May 2015

A B S T R A C TThe spotlight of UOJM’s 4th issue is medical education. We met with Dr. Viren Naik, anesthesiologist, associate professor at the University of Ottawa (uOttawa), and Medical Director of the University of Ottawa Skills and Simulation Centre (uOSSC). He is also a core team member of the Academy of Innovation in Medical Education (AIME), uOttawa’s centre for advancing medical education research. Dr. Naik is actively involved in research, with over 60 peer-reviewed publications and grants. He was also the previous chair of the Written Examination in Anesthesia with the Royal College of Physicians and Surgeons of Canada. In this interview, we discuss the advancement of medical education with the skills and simulation centre, the future of the medical curriculum, and how to be involved in medical education as students. R É S U M ÉDans cette 4e édition du JMUO, le sujet mis en lumière est l’éducation médicale. Nous avons rencontré le Dr Viren Naik, anesthésiologiste, professeur agrégé de l’Université d’Ottawa (uOttawa) et directeur médical du Centre de compétences et simulation de l’Université d’Ottawa (CCSUO). C’est aussi un membre important de l’Académie pour l’innovation en éducation médicale (AIME), le centre de l’Université d’Ottawa qui a pour but de faire avancer la recherche en éducation médicale. Dr Naik est un chercheur très dynamique qui a plus de 60 publications et subventions évaluées par les pairs à son actif. Dans le passé, il a aussi présidé l’examen écrit en anesthésiologie du Collège royal des médecins et chirurgiens du Canada. Durant l’entrevue, nous avons discuté de l’avancement de l’éducation médicale au Centre de compétences et simulation, de l’avenir du cursus médical et de la façon que les étudiants peuvent participer à l’éducation médicale.
The Potential of Video in Patient Education Post Skin Biopsies
Authors: Cho Natalie , Chambers Reid 
Published: May 2015

Plastic surgeons perform excisional skin biopsies that may be in aesthetically sensitive areas. Excisional biopsies are performed on an outpatient basis and therefore patients are expected to perform wound care at home. The current standard of patient education for post-procedural care is verbal information along with a written set of instructions to take home. However, a patient’s comprehension of verbal directions and literacy level can greatly affect the transmission of knowledge, and verbal instructions are not standardized across each patient encounter. The importance of patient education in self-care with the use of video has great potential in promoting improved outcomes.