bluuebunny/crossref_metadata_2025_split huggingface dataset:
Medication-related burden and its association with medication adherence among elderly tuberculosis patients in Guizhou, China: a cross-sectional study
Authors: Wang Yun , Jian Sisi , Huang Zhongfeng , Chen Huijuan , Hu Yuanxia , Fang Shilin 
Published: August 2024

IntroductionTuberculosis (TB) morbidity and mortality are significantly increasing in the elderly worldwide. Their optimal health outcomes are hampered by medication related burden (MRB) and poor treatment adherence. Understanding th e MRB status from patients’ perspectives and its association with adherence among elderly TB patients will help achieve the End TB targets. Thus, we aimed to identify the incidence of MRB and nonadherence among elderly TB patients in Guizhou, and determine their association.MethodsA cross-sectional study was conducted in three prefectures with high TB notifications in Guizhou in 2022. The data were collected via face-to-face structured interviews. MRB was measured using the Living with Medicines Questionnaire version 3 (LMQ-3), which consists of eight domains. Nonadherence was assessed by treatment interruption, which was defined as any interruption lasting at least 1 day at any time within the last 3 months. A binary unconditional logistic regression model was used to determine the association between variables.ResultsOf the 405 elderly TB patients enrolled, 49.4% and 42.7% of the respondents perceived suffering from moderate and high MRB, respectively. The incidence of nonadherence among patients was 33.6%. Patients with higher scores in domain 2 (practical difficulties) [ORadj = 1.19; 95% CI (1.11–1.28)] and domain 4 (side effects burden of prescribed medications) [ORadj = 1.16; 95% CI (1.06–1.27)] were more likely to experience nonadherence. But, patients with higher scores in domain 8 (control/autonomy of medicine use) [ORadj = 0.70; 95% CI (0.61, 0.81)] were more likely to occur adherence. Patients with a high education level [ORadj = 0.29; 95% CI (0.08, 0.92)] had a decreased risk of nonadherence, but those with a living expense from a retirement salary [ORadj = 2.55; 95% CI (1.16, 5.71)] had an increased risk of nonadherence.DiscussionThe incidence of MRB and medication nonadherence is high among elderly TB patients in Guizhou. The significant associations between the three domains of MRB and nonadherence highlight that measuring MRB in multiple dimensions using the LMQ-3 in elderly TB patients could assist clinicians in providing patient-centered care, and multifaceted interventions targeting the identified problems should be implemented to reduce MRB and nonadherence among elderly TB patients in Guizhou.
Niches, interspecific associations, and community stability of main understory regeneration species after understory removal in temperate forests
Authors: Zhang Yanyan , Zhou Wangming , Yuan Quan , Deng Jiaojiao , Zhou Li , Yu Dapao 
Published: August 2024

IntroductionUnderstory removal is frequently used to relieve the renewal pressure on trees and promote the growth capability of trees for maintaining community stability, while the lack of previous study on temperate forests limits our assessment of the effectiveness of this essential management measurement.MethodsIn this study, we calculated the niche characteristics and interspecific association of main understory species and community stability in temperate forests [original broad-leaved Korean pine forest (BKF), Betula platyphylla secondary forest (BF), and Larix gmelinii plantation (LF)] after understory removal for characterizing the resource utilization capacity of the regeneration trees.ResultsDuring the restoration stage, the niche breadth of understory plants with similar habits varied across stands and layers; regeneration tree species with heliophile and semishade occupied a larger niche in BKF and LF, while it was the opposite in LF. Niche overlap among heliophile regeneration trees increased in both BKF and BF, but not in LF. The interspecific association among main species revealed that the distribution of each species was independent and the interspecific association was loose and it varied in different forests and different light-demanding species with regeneration trees. The stability of shrub communities in BF and LF improved whereas that of BKF declined, while that of the herb communities of corresponding forests showed the opposite state.DiscussionOur study demonstrated that the effectiveness of understory removal depends on species’ ecological habits, which enhances the renewal and resource utilization capacity of regeneration tree species in temperate forests and shrub community stability in BF and LF.
Postpartum depression and autoimmune disease: a bidirectional Mendelian randomization study
Authors: Yu Wenlong , Su Bingxue , Wang Chaoqun , Xia Qing , Sun Yinxiang 
Published: August 2024

PurposeThe rising prevalence of postpartum depression (PPD) is harmful to women and families. While there is a growing body of evidence suggesting an association between PPD and autoimmune diseases (ADs), the direction of causality remains uncertain. Therefore, Mendelian randomization (MR) study was employed to investigate the potential causal relationship between the two.MethodsThis study utilized large-scale genome-wide association study genetic pooled data from two major databases: the IEU OpenGWAS project and the FinnGen databases. The causal analysis methods used inverse variance weighting (IVW). The weighted median, MR-Egger method, MR-PRESSO test, and the leave-one-out sensitivity test have been used to examine the results’ robustness, heterogeneity, and horizontal pleiotropy.ResultsA total of 23 ADs were investigated in this study. In the IVW model, the MR study showed that PPD increased the risk of type 1 diabetes (OR , = 1.15 (1.05–1.26),p&lt;0.01),Hashimoto’s thyroiditis((OR) = 1.21 (1.09–1.34),p&lt;0.0001),encephalitis((OR) = 1.66 (1.06–2.60),p&lt;0.05). Reverse analysis showed that ADs could not genetically PPD. There was no significant heterogeneity or horizontal pleiotropy bias in this result.ConclusionOur study suggests that PPD is a risk factor for type 1 diabetes, Hashimoto’s thyroiditis, and encephalitis from a gene perspective, while ADs are not a risk factor for PPD. This finding may provide new insights into prevention and intervention strategies for ADs according to PPD patients.
Network meta-analysis of the efficacy of physical exercise interventions on vision health in children and adolescents
Authors: Liu Jianming , Lan Wencen , Zhang Danxuan 
Published: August 2024

ObjectiveThis study systematically evaluates the impact of different physical exercise modalities on vision health interventions for Chinese children and adolescents.MethodsA comprehensive search was conducted in databases, including Web of Science, PubMed, EBSCO, MEDLINE, Embase, and CNKI. The focus was on randomized controlled trial (RCT) studies related to physical activity interventions for vision health in this demographic. The search covered literature from the inception of each database until May 1, 2023. Two researchers independently conducted literature screening, data extraction, and risk of bias assessment, adhering to pre-established inclusion and exclusion criteria. A network meta-analysis was performed using the “Network” package in Stata 14.2.ResultsThe analysis encompassed 17 studies with 1,840 participants aged 7 to 18 years. Findings from the network meta-analysis revealed that badminton [MD = 0.23 (0.12, 0.33), p &lt; 0.001] and table tennis [MD = 0.16 (0.09, 0.22), p &lt; 0.001] exercises, along with health education [MD = 0.13 (0.03, 0.23), p = 0.013], were statistically significant in enhancing vision health compared to no intervention. According to the Surface Under the Cumulative Ranking (SUCRA) probability ranking, badminton (SUCRA = 96.7) and table tennis (SUCRA = 84.1) emerged as the most effective modalities for myopia intervention in children and adolescents, with health education (SUCRA = 73.2) following closely.ConclusionPhysical exercise significantly contributes to the healthy development of vision in children and adolescents. Among various activities, badminton and table tennis are the most effective in improving visual health, highlighting the need for augmented promotion of visual health education. However, the quantity and quality of the included studies necessitate further high-quality intervention research to confirm these findings.
Health resource allocation within the close-knit medical consortium after the Luohu healthcare reform in China: efficiency, productivity, and influencing factors
Authors: Gong Fangfang , Zhou Ying , Luo Junxia , Hu Guangyu , Lin Hanqun 
Published: August 2024

ObjectiveThis study aims to assess the efficiency and productivity of the Luohu Hospital Group after the reform and to identify factors influencing the efficiency to support the future development of medical consortia.MethodsData on health resources from Shenzhen and the Luohu Hospital Group for the years 2015 to 2021 were analyzed using the super-efficiency slack-based measure data envelopment analysis (SE-SBM-DEA) model, Malmquist productivity index (MPI), and Tobit regression to evaluate changes in efficiency and productivity and to identify determinants of efficiency post-reform.ResultsAfter the reform, the efficiency of health resource allocation within the Luohu Hospital Group improved by 33.87%. Community health centers (CHCs) within the group had an average efficiency score of 1.046. Moreover, the Luohu Hospital Group’s average total factor productivity change (TFPCH) increased by 2.5%, primarily due to gains in technical efficiency change (EFFCH), which offset declines in technical progress change (TECHCH). The efficiency scores of CHCs were notably affected by the ratio of general practitioners (GPs) to health technicians and the availability of home hospital beds.ConclusionThe reform in the Luohu healthcare system has shown preliminary success, but continuous monitoring is necessary. Future strategies should focus on strengthening technological innovation, training GPs, and implementing the home hospital bed policy. These efforts will optimize the efficiency of health resource allocation and support the integration and development of resources within the medical consortium.
Variables associated with the relationship between obesity and mental health among university students in the Gulf Cooperation Council countries: a systematic review
Authors: Joma Amjad , Abuzerr Samer , Alsoudi Sharif 
Published: August 2024

BackgroundVarious factors, including dietary habits, lifestyle choices, socio-economic status, cultural attitudes, academic stress, and access to mental health support services, influence the relationship between obesity and mental health among university students in Gulf Cooperation Council (GCC) countries. Understanding these complex interactions is crucial for developing effective interventions to promote both physical and mental well-being among students in the region. Therefore, this systematic review aims at understanding the variables associated with the relationship between obesity and mental health among university students in the (GCC) countries.MethodsThis systematic review protocol was registered with the International Prospective Register of Systematic Reviews (PROSPERO) [CRD42024517806]. We conducted a systematic literature search using electronic databases including PubMed, PsycINFO, Scopus, CINAHL, Web of Science, and Google Scholar to identify relevant studies published up to 28-February-2024. A narrative synthesis approach was employed to summarize the findings of included studies. Data were synthesized according to predefined themes related to variables associated with the relationship between obesity and mental health among university students in GCC countries.ResultsThe prevalence of overweight and obesity among university students in GCC countries is alarmingly high, with a mean rate of 29.4%. Depression, anxiety, and body image dissatisfaction are significantly associated with obesity in this population. Poor sleep patterns are both a predictor and a consequence of obesity-related mental health issues. Socio-cultural factors play a crucial role in shaping students’ perceptions of body image and mental health.ConclusionThese findings highlight the importance of comprehensive approaches to address the intertwined nature of obesity and mental health in this population, necessitating targeted interventions and further research efforts.
Systematic transcriptomic analysis and temporal modelling of human fibroblast senescence
Authors: Scanlan R.-L. , Pease L. , O’Keefe H. , Martinez-Guimera A. , Rasmussen L. , Wordsworth J. , Shanley D. 
Published: August 2024

Cellular senescence is a diverse phenotype characterised by permanent cell cycle arrest and an associated secretory phenotype (SASP) which includes inflammatory cytokines. Typically, senescent cells are removed by the immune system, but this process becomes dysregulated with age causing senescent cells to accumulate and induce chronic inflammatory signalling. Identifying senescent cells is challenging due to senescence phenotype heterogeneity, and senotherapy often requires a combinatorial approach. Here we systematically collected 119 transcriptomic datasets related to human fibroblasts, forming an online database describing the relevant variables for each study allowing users to filter for variables and genes of interest. Our own analysis of the database identified 28 genes significantly up- or downregulated across four senescence types (DNA damage induced senescence (DDIS), oncogene induced senescence (OIS), replicative senescence, and bystander induced senescence) compared to proliferating controls. We also found gene expression patterns of conventional senescence markers were highly specific and reliable for different senescence inducers, cell lines, and timepoints. Our comprehensive data supported several observations made in existing studies using single datasets, including stronger p53 signalling in DDIS compared to OIS. However, contrary to some early observations, both p16 and p21 mRNA levels rise quickly, depending on senescence type, and persist for at least 8–11 days. Additionally, little evidence was found to support an initial TGFβ-centric SASP. To support our transcriptomic analysis, we computationally modelled temporal protein changes of select core senescence proteins during DDIS and OIS, as well as perform knockdown interventions. We conclude that while universal biomarkers of senescence are difficult to identify, conventional senescence markers follow predictable profiles and construction of a framework for studying senescence could lead to more reproducible data and understanding of senescence heterogeneity.
Indigenous climate change mitigation strategies in tropical cities – a review
Authors: Akinkuolie Timothy A. , Ogunbode Timothy O. , Adekiya Aruna O. , Fapohunda Michael T. 
Published: August 2024

IntroductionClimate change poses numerous issues for indigenous populations in tropical cities worldwide, including reduced access to food, dwindling resources, and the proliferation of vector-borne illnesses. Indigenous communities are developing various mitigation and adaptation measures suitable for their distinct cultural and ecological demands.MethodsThis study investigates the numerous indigenous climate change mitigation strategies (ICCMSs) being deployed in tropical cities, using secondary sources of data. The methodology involved a systematic review based on PRISMA guidelines, encompassing the identification, screening, eligibility, and inclusion of relevant literature. From an initial 1,200 sources, 450 were screened, and 102 met the inclusion criteria for full-text assessment.ResultsFindings indicate that common ICCMSs in tropical cities include the use of traditional knowledge systems and materials in urban green infrastructure projects, agroforestry, sustainable urban agriculture, urban afforestation and reforestation, and indigenous technologies and innovations in waste management practices. Indigenous peoples have benefited from greater education and understanding about climate change, empowering them to take action and lower their greenhouse gas (GHG) emissions.DiscussionThe study recommends that governments and international organizations support these mitigation efforts, incorporate them into public policy and urban planning for indigenous communities in tropical cities, and reduce global anthropogenic GHG emissions. Further studies are suggested to assess the effectiveness of these measures and their potential to enhance climate resilience in tropical cities.
Heart rate of fire: exploring direct implementation of physiological measurements in realistic shoot/don't-shoot simulations
Authors: Biggs Adam T. , Jensen Andrew E. , Kelly Karen R. 
Published: August 2024

IntroductionShooting simulations provide an excellent opportunity to train use-of-force decisions in controlled environments. Recently, military and law enforcement organizations have expressed a growing desire to integrate physiological measurement into simulations for training and feedback purposes. Although participants can easily wear physiological monitors in these scenarios, direct implementation into training may not be simple. Theoretical problems exist in the ultra-short heart rate variability windows associated with use-of-force training, and practical problems emerge as existing scenario libraries at training organizations were not designed for physiological monitoring.MethodsThe current study explored the challenges and possibilities associated with direct implementation of physiological monitoring into an existing library of firearms training scenarios. Participants completed scenarios in a shooting simulator using existing military training scenarios while wearing a device to monitor their heart rate.ResultsThe results revealed lower heart rate variability (approximately 6%) occurred in scenarios where participants did not have to fire weapons, indicating that don't-shoot scenarios may actually impose more cognitive stress on shooters. Additional evidence further demonstrated how both behavioral and physiological factors could be used concomitantly to predict unintentionally firing on non-hostile actors. However, behavioral measures were more predictive (e.g., β = .221) than physiological measures (e.g., β = −.132) when the latter metrics were limited to specific scenarios. Qualitative results suggest that simply applying physiological monitoring to existing shooting simulations may not yield optimal results because it would be difficult to directly integrate physiological measurement in a meaningful way without re-designing some elements of the simulations, the training procedure, or both.DiscussionFuture use-of-force shooting simulations should consider designing novel scenarios around the physiological measurement rather than directly implementing physiological assessments into existing libraries of scenarios.
Factors Associated With Cervical Cancer Screening Attendance in Hungary Based on the European Health Interview Survey
Authors: Pataki Jenifer , Szőllősi Gergő József , Sárváry Attila , Dombrádi Viktor 
Published: August 2024

ObjectivesThis study assessed the change in cervical cancer screening attendance across 10 years and identified the associated factors.MethodsData from the European Health Interview Surveys in Hungary (2009, 2014, 2019) were analyzed with multivariate and multiple logistic regressions.ResultsThe analysis involved 4,850 participants, revealing a significant (p &lt; 0.001) increase in screening attendance from 69% to 77% over 10 years. Factors significantly associated with higher attendance rates included a higher education level (tertiary level AOR = 2.51 [2.03–3.09]), being in a relationship (AOR = 1.59 [1.39–1.83]), the belief that one can do much for one’s health (OR = 1.26 [1.05–1.52]), and the absence of chronic health problems (AOR = 1.56 [1.33–1.84]). Lower screening odds were significantly correlated with worse self-perceived health status (AOR = 0.65 [0.52–0.81]) and less frequent doctor (AOR = 0.64 [0.54–0.76]) and specialist visits (AOR = 0.46 [0.39–0.53]).ConclusionEnhancing cervical cancer screening rates requires tailored public health strategies, particularly targeting individuals with lower education and poor health perceptions. Public health initiatives and enhanced collaboration among healthcare professionals are required to further increase participation rates, particularly among the identified groups.
IMPROVING THE PROJECT MANAGEMENT OF SUSTAINABLE DEVELOPMENT OF AN ENERGY COMPANY
Authors: Суслов Е.Ю. , Шульженко А.А. 
Published: August 2024

В современном мире, характеризующемся высокой турбулентностью и неопределенностью внешней среды, для обеспечения устойчивого развития организациям требуется в значительной степени повышать скорость внедрения инноваций в производственные и управленческие процессы. Методы проектного управления играют важную роль в осуществлении устойчивого развития, так как они позволяют эффективно планировать, контролировать и реализовывать инновационные проекты, направленные на достижение стратегических целей, и обеспечивают достижение запланированных результатов в любых организациях. Эффективность реализации проектов в значительной степени зависит от зрелости системы проектного управления в конкретной компании. Целью данной статьи является уточнение методов и инструментов анализа современного состояния системы проектного управления и обоснование направлений ее совершенствования на примере одной из крупных специализированных энергетических компаний для обеспечения ее устойчивого развития. Для достижения поставленной цели был проведен анализ системы управления компании, проведена авторская оценка зрелости системы управления проектами с применением двух альтернативных моделей. По результатам оценки сделан вывод о достигнутом уровне зрелости системы проектного управления, предложены и обоснованы направления по ее совершенствованию.
In the modern world, characterized by high turbulence and uncertainty of the external environment, in order to ensure sustainable development, organizations need to significantly increase the speed of innovation in production and management processes. Project management methods play an important role in the implementation of sustainable development, as they make it possible to effectively plan, control and implement innovative projects aimed at achieving strategic goals, and ensure the achievement of planned results in any organization. The effectiveness of project implementation largely depends on the maturity of the project management system in a particular company. The purpose of this article is to clarify the methods and tools for analyzing the current state of the project management system and substantiate the directions for its improvement in one of the large specialized energy companies to ensure its sustainable development. To achieve this goal, an analysis of the company's management system was carried out, an assessment of the maturity of the project management system was carried out using two alternative models. Based on the results of the assessment, a conclusion was made about the achieved level of maturity of the project management system, directions for its improvement were proposed and justified.