bluuebunny/crossref_metadata_2025_split huggingface dataset:
Paediatric Crohn’s disease: histologic findings at initial presentation
Authors: Spasic Smiljana , Pankaj Amaya , Kaplan Jess L , Patil Deepa , Moran Christopher J , Deshpande Vikram 
Published: July 2024

BackgroundDiagnosing paediatric Crohn’s disease (CD) based on histology can present challenges. We evaluate the histological spectrum of treatment-naïve biopsies from children with CD and assess these findings’ diagnostic and predictive value.MethodsThree cohorts were identified: (1) 137 patients with CD, (2) 116 patients with ulcerative colitis (UC) and (3) 50 patients without inflammatory bowel disease. Biopsies from the gastrointestinal (GI) tract were re-examined for signs of active and chronic inflammation, including lymphocyte-pattern oesophagitis, focal enhancing gastritis and indicators of chronicity. Additionally, granulomas and microgranulomas (defined as clusters of 4–9 epithelioid histiocytes) were evaluated.ResultsLymphocyte-pattern oesophagitis was observed in 15% of patients (n=20). Moderate-to-severe diffuse gastritis was noted in 50.4% of patients (n=68), while focal enhancing gastritis was identified in 11.1% (n=15). In terminal ileal biopsies, 46.1% exhibited activity and 5.3% showed features of chronicity. Active colitis was present in 73% of patients (n=100), with chronic colitis seen in 11.7% (n=16). Granulomas and microgranulomas were observed in 31.4% (43/137) and 48.9% (67/137) of patients, respectively. Notably, 30.7% (42/137) of patients with microgranulomas were without granulomas. Previously undetected microgranulomas were found in 20 of 27 cases. 2.5% of patients with UC and none of the control cohort showed microgranulomas. Lymphocyte-pattern oesophagitis was associated with an increased need for anti-tumor necrosis factor (TNF) therapy (p=0.007).ConclusionsGI microgranulomas, often overlooked, are specific to CD in the proper clinical context. Oesophageal lymphocytosis may predict a need for more aggressive treatment. The study brings to light under-recognised aspects of CD’s histological diagnosis, including the oversight of microgranulomas, the high prevalence of diffuse gastritis and low prevalence of focal enhancing gastritis, the frequent absence of terminal ileitis and the infrequent occurrence of chronic colitis.
Digital innovative healthcare during a pandemic and beyond: a showcase of the large-scale and integrated Saudi smart national health command centre
Authors: Alharbi Muaddi F , Senitan Mohammmed , Mominkhan Dalia , Smith Sidney , ALOtaibi Maram , Siwek Michal , Ohanlon Tim , Alqablan Fahad , Alqahtani Sarah , Alabdulaali Mohammed K 
Published: July 2024

IntroductionThe increasing frequency of pandemics, demand for healthcare and costs of healthcare services require efficient health systems with integrated care via a command centre that ensures a centralised and coordinated approach to exercise effective leadership.DescriptionWe present a case study using the conceptual framework of Franklin to describe the novel system-based engineering approach of the Saudi National Health Command Centre (NHCC) including its features and outcomes measured.DiscussionThe NHCC is structured into four departments and four zones with real-time data integration and visualisation on 88 dashboards. To empower leadership, it harnesses artificial intelligence affordances such as machine learning algorithms to enhance functionality, decision-making processes and overall performance. This allows for the rapid assessment of available resources and to monitor healthcare system efficiency at diverse levels of clinical and system indicators. Enhanced proactive capacity management has contributed to reducing lengths of stay, average supply chain lead time and surgery waiting list; early bending of the COVID-19 curve resulting in a low mortality rate; increasing bed capacity; deploying medical staff and mechanical ventilators rapidly; rolling out the COVID-19 vaccination programme and improving patient satisfaction.ConclusionIntegrating a healthcare system with a command centre provides healthcare leaders with the necessary infrastructure to create synergy between people, processes and technologies. This substantially improves both patient and service outcomes. It also allows for immediate care coordination and resource allocations and safeguards ease of access to care.
Awareness and perceived behaviour changes following the New York state vaping flavour ban, 2021–2022
Authors: Schneller Liane M , Reid Jessica L , Kasza Karin A , O'Connor Richard J , Hyland Andrew , Hammond David 
Published: July 2024

SignificanceDespite an electronic cigarette (e-cigarette) flavour ban in New York (NY) since May 2020, most youth who vape continue to report vaping restricted flavours. This study aims to examine youth awareness and perceived behaviour change associated with the NY vaping flavour ban.MethodsNY cross-sectional data from 2021 and 2022 ITC Youth Survey were combined and analysed (N=1014). Weighted analyses were used to describe awareness and understanding of the e-cigarette flavour ban, as well as changes in tobacco use behaviour.ResultsOnly 0.9% (n=8) of NY youth understood the flavour ban, in that they were both aware of the flavour ban in all stores and accurately reported that all non-tobacco flavours were banned. Awareness and understanding of the flavour ban differed by vaping status (p<0.01): respondents who had vaped in the past 12 months or 30 days were more likely (adjusted OR (aOR)=2.15, 95% CI 1.34, 3.45; aOR=2.07, 95% CI 1.17, 3.64, respectively) to be aware of the flavour ban but misunderstand the stores or flavours included. Of the majority of youth who reported awareness of a flavour ban and vaped (n=122) or smoked (n=78) in the past 12 months reported no changes in behaviour (64.0% and 69.7%, respectively).ConclusionsLess than one-third of NY youth, regardless of vaping status, reported that an e-cigarette flavour ban was present where they live. Further, most youth who were aware of the ban misunderstood which flavours were restricted and/or that the ban applied to all stores that sold e-cigarettes. Increased enforcement and educational efforts could improve awareness and understanding of the NY e-cigarette flavour ban.
Stability study of coal pillars due to induced stress-driven spalling during development and mechanised depillaring at different depths of cover
Authors: Singh Abhishek Kumar , Ram Sahendra , Kumar Ashok , Waclawik Petr , Kukutsch Radovan 
Published: July 2024

Induced stress-driven spalling in coal pillars depends on several factors including depth of cover, in situ stresses, and presence of weak planes. A solid coal pillar generally experiences spalling at a higher depth. Fender and snook/rib experiences considerable spalling during depillaring even at lower depth below strong and massive rock mass. The spalling in pillars leads to instability at working places including goaf encroachment during depillaring. This paper discusses the measurement of induced stress-driven spalling during development of a seam having weak roof–pillar interface at 850–900 m at CSM mine in Czech Republic. Spalling is also examined in different form of coal pillars during mechanized depillaring at 250 m depth at Godavarikhani 11 Incline mine in India. Finite difference based numerical modelling was carried out to assess the behaviour of the pillars. Ultimate non-elastic region was observed up to 9 m near the roof−pillar interface due to presence of weak plane and around 8 m at middle height of the pillar at the higher depth. At the moderate depth of around 250 m, maximum vertical induced stress was observed over a fender. Spalling of 2 and 1.5 m was observed in the fender and pillar, respectively.
Molecular Recognition of VSIG1 in Biological Samples for Fast Diagnosis of Gastric Cancer
Authors: Stefan-van Staden Raluca-Ioana , Gheorghe Damaris-Cristina , Ilie-Mihai Ruxandra-Maria 
Published: July 2024

VSIG1 is a new biomarker member of the JAM family relevant in gastric cancer diagnostics. Due to its detection and quantification impact for fast and early diagnosis of gastric cancer, two types of intelligent miniplatforms based on stochastic sensors as detection tools, were designed and validated using real samples. A 3D stochastic microsensor based on Nitrogen and Sulfur dopped graphene paste modified with calix[4]arene-25,26,27,28-tetrol, and a 2D disposable screen-printed stochastic sensor based on thin film gold modified with calix[4]arene-25,26,27,28-tetrol were constructed and inserted as working sensors into the miniplatforms. The proposed intelligent miniplatforms shown sensitivities as high as 1.12 × 1010 s−1g−1ml, limits of determination of 1 × 10−23g ml−1, and working concentration ranges between 1 × 10−23 and 1 × 10−8 g ml−1. Recoveries higher than 99.30% with % RSD values lower than 0.05% were obtained when used for screening test of biological samples, for VSIG1.
CCN6 Suppresses Metaplastic Breast Carcinoma by Antagonizing Wnt/β-Catenin Signaling to Inhibit EZH2-Driven EMT
Authors: Gonzalez Maria E. , Brophy Bryce , Eido Ahmad , Leonetti Adele E. , Djomehri Sabra I. , Augimeri Giuseppina , Carruthers Nicholas J. , Cavalcante Raymond G. , Giordano Francesca , Andò Sebastiano , Nesvizhskii Alexey I. , Fearon Eric R. , Kleer Celina G. 
Published: July 2024

Abstract
Metaplastic breast carcinomas (mBrCA) are a highly aggressive subtype of triple-negative breast cancer with histologic evidence of epithelial-to-mesenchymal transition and aberrant differentiation. Inactivation of the tumor suppressor gene cellular communication network factor 6 (CCN6; also known as Wnt1-induced secreted protein 3) is a feature of mBrCAs, and mice with conditional inactivation of Ccn6 in mammary epithelium (Ccn6-KO) develop spindle mBrCAs with epithelial-to-mesenchymal transition. Elucidation of the precise mechanistic details of how CCN6 acts as a tumor suppressor in mBrCA could help identify improved treatment strategies. In this study, we showed that CCN6 interacts with the Wnt receptor FZD8 and coreceptor LRP6 on mBrCA cells to antagonize Wnt-induced activation of β-catenin/TCF-mediated transcription. The histone methyltransferase EZH2 was identified as a β-catenin/TCF transcriptional target in Ccn6-KO mBrCA cells. Inhibiting Wnt/β-catenin/TCF signaling in Ccn6-KO mBrCA cells led to reduced EZH2 expression, decreased histone H3 lysine 27 trimethylation, and deregulation of specific target genes. Pharmacologic inhibition of EZH2 reduced growth and metastasis of Ccn6-KO mBrCA mammary tumors in vivo. Low CCN6 is significantly associated with activated β-catenin and high EZH2 in human spindle mBrCAs compared with other subtypes. Collectively, these findings establish CCN6 as a key negative regulator of a β-catenin/TCF/EZH2 axis and highlight the inhibition of β-catenin or EZH2 as a potential therapeutic approach for patients with spindle mBrCAs.
Significance: CCN6 deficiency drives metaplastic breast carcinoma growth and metastasis by increasing Wnt/β-catenin activation to upregulate EZH2, identifying EZH2 inhibition as a mechanistically guided treatment strategy for this deadly form of breast cancer.
Therapeutic Targeting of the GLS1–c-Myc Positive Feedback Loop Suppresses Glutaminolysis and Inhibits Progression of Head and Neck Cancer
Authors: Yang Jianqiang , Chen Fanghui , Lang Liwei , Yang Fan , Fu Zhenzhen , Martinez Juan , Cho Amber , Saba Nabil F. , Teng Yong 
Published: July 2024

Abstract
Head and neck squamous cell carcinoma (HNSCC) is addicted to glutaminolysis. Targeting this metabolic dependency has emerged as a potential therapeutic approach for HNSCC. In this study, we conducted a bioinformatic analysis of The Cancer Genome Atlas HNSCC cohort that revealed a robust correlation between expression of MYC (encoding the protein c-Myc) and glutaminase 1 (GLS1), which catalyzes the first step in glutaminolysis. Intriguingly, disruption of GLS1 signaling in HNSCC cells by genetic depletion or CB-839 treatment resulted in a reduction in c-Myc protein stability via a ubiquitin-specific peptidase 1–dependent ubiquitin–proteasome pathway. On the other hand, c-Myc directly binds to the promoter region of GLS1 and upregulates its transcription. Notably, the GLS1–c-Myc pathway enhanced acetyl-coenzyme A carboxylase–dependent Slug acetylation, prompting cancer cell invasion and metastasis. Thus, the GLS1–c-Myc axis emerged as a positive feedback loop critical for driving the aggressiveness of HNSCC. Therapeutically, combining CB-839 with the c-Myc inhibitor MYCi975 strongly suppressed GLS1–c-Myc signaling, resulting in a superior antitumor effect compared with either single agent in an orthotopic mouse model of HNSCC. These findings hold promise for the development of effective therapies for patients with HNSCC, addressing an urgent need arising from the significant incidence and high metastatic rate of the disease.
Significance: GLS1 and c-Myc form a positive feedback loop that promotes head and neck cancer metastasis and can be targeted as a promising therapeutic strategy for this disease.
Notice of Retraction: The Investment Risk Effect of Stock Returns In LQ-45 Index Companies on Foreign and Domestic Investors
Authors: Sari Pristin Prima , Hermuningsih Sri , Prajnanta Final , Rahmawati Anisya Dewi 
Published: July 2024

This article has been retracted by the publisher.
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This article has been retracted at the request of the Authors. The editors and authors have jointly made the decision to retract the paper. Reasonable effort should be made to remove references to this paper.
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Foreign and domestic investors may have an impact on changes in LQ-45 stock returns on the Indonesia stock exchange. The impact given by foreign and domestic investors can be negative or positive for the capital market. The purpose of this study was to find empirical evidence of the effect of systematic risk by foreign and domestic investors on changes in stock returns. The research method uses quantitative methods from the stock trading reports of LQ-45 companies. The data is processed using the IBM 25 SPSS statistical tool. The population in this study is the stock return of LQ-45 companies listed on the Indonesia Stock Exchange. Sample data is the stock return of the LQ-45 Companies on January 2, 2020-2023. The novelty of the study is the systematic risk variable, which is the driving force to moderate the influence of foreign and domestic investors on stock returns. The results of the study showed that the systematic risk variable had a negative effect on stock returns, foreign investors had no effect on stock returns, and domestic investors had a positive effect on stock returns. The amount of low systematic risk can affect the increase in stock returns. The number of domestic investors can affect the increase in stock returns. The study could have practical implications for investors, regulators, policymakers, and academics by providing empirical evidence and insights into the interplay between systematic risk, investor types (foreign and domestic), and stock returns in the Indonesian capital market.
PRADOC: A Multicenter Randomized Controlled Trial to Assess the Efficiency of PRADO‐IC, a Nationwide Pragmatic Transition Care Management Plan for Hospitalized Patients With Heart Failure in France
Authors: Roubille François , Labarre Jean‐Philippe , Georger Frédéric , Galinier Michel , Herman Fanchon , Berdague Philippe , Nogue Erika , Petroni Thibaut , Delbaere Quentin , Malak Alexandre , Robin Marie , Prunet Elvira , Leclercq Florence , Pasquie Jean‐Luc , Papinaud Laurence , Mercier Grégoire , Ricci Jean‐Etienne , Cayla Guillaume , Duflos Claire 
Published: July 2024

Background
The PRADO‐IC (Programme de Retour à Domicile après une Insuffisance Cardiaque) is a transition care program designed to improve the coordination of care between hospital and home that was generalized in France in 2014. The PRADO‐IC consists of an administrative assistant who visits patients during hospitalization to schedule follow‐up visits. The aim of the present study was to evaluate the PRADO‐IC program based on the hypotheses provided by health authorities.

Methods and Results

The PRADOC study is a multicenter, controlled, randomized, open‐label, mixed‐method trial of the transition program PRADO‐IC versus usual management in patients hospitalized with heart failure (standard of care group; NCT03396081). A total of 404 patients were recruited between April 2018 and May 2021. The mean patient age was 75 years (±12 years) in both groups. The 2 groups were well balanced regarding severity indices. At discharge, patients homogeneously received the recommended drugs. There was no difference between groups regarding hospitalizations for acute heart failure at 1 year, with 24.60% in the standard of care group and 25.40% in the PRADO‐IC group during the year following the index hospitalization (hazard ratio, 1.04 [95% CI, 0.69–1.56];
P
=0.85) or cardiovascular mortality (hazard ratio, 0.67 [95% CI, 0.34–1.31];
P
=0.24).

Conclusions
The PRADO‐IC has not significantly improved clinical outcomes, though a trend toward reduced cardiovascular mortality is evident. These results will help in understanding how transitional care programs remain to be integrated in pathways of current patients, including telemonitoring, and to better tailor individualized approaches.

REGISTRATION

URL:
https://www.clinicaltrials.gov
; Unique Identifier: NCT03396081.
Saliva, Plasma, and Multifluid Metabolomic Signatures of Periodontal Disease, Type 2 Diabetes Progression, and Markers of Glycemia and Dyslipidemia Among Puerto Rican Adults With Overweight and Obesity
Authors: Wang Zicheng , Haslam Danielle E. , Sawicki Caleigh M. , Rivas‐Tumanyan Sona , Hu Frank B. , Liang Liming , Wong David T. W. , Joshipura Kaumudi J. , Bhupathiraju Shilpa N. 
Published: July 2024

Background
Evidence from cohort studies indicates a bidirectional relationship between periodontal disease and type 2 diabetes (T2D), but the underlying mechanisms remain unknown. In this study, we aimed to (1) identify saliva, plasma, and multifluid metabolomic signatures associated with periodontal disease and (2) determine if these signatures predict T2D progression and cardiometabolic biomarkers at year 3.

Methods and Results

We included participants from the SOALS (San Juan Overweight Adult Longitudinal Study) (n=911). Metabolites from saliva (k=635) and plasma (k=1051) were quantified using liquid chromatography–mass spectrometry. We applied elastic net regression with 10‐fold cross‐validation to identify baseline metabolomic signatures of periodontal disease. Multivariable Cox proportional hazards regression and linear regression were used to evaluate the association with T2D progression and biomarker concentrations. Metabolomic profiles included highly weighted metabolites related to lysine and pyrimidine metabolism. Periodontal disease or its 3 metabolomic signatures were not associated with T2D progression in 3 years. Prospectively, 1‐SD increments in the multifluid and saliva metabolomic signatures were associated with higher low‐density lipoprotein (multifluid: 12.9±5.70,
P
=0.02; saliva: 13.3±5.11,
P
=0.009). A 1‐SD increment in the plasma metabolomic signature was also associated with Homeostatic Model Assessment for Insulin Resistance (2.67±1.14,
P
=0.02) and triglyceride (0.52±0.18,
P
=0.002).

Conclusions
Although metabolomic signatures of periodontal disease could not predict T2D progression, they were associated with low‐density lipoprotein, triglyceride, and Homeostatic Model Assessment for Insulin Resistance levels at year 3.
Encephaloduroarteriosynangiosis for Symptomatic Intracranial Atherosclerotic Arterial Steno‐Occlusive Disease: Clinical and Radiological Outcomes
Authors: Wang Xiao‐Peng , Ren Bin , Wang Qian‐Nan , Li Jing‐Jie , Liu Jia‐Qi , Yu Dan , Zhang Qian , Bao Xiang‐Yang , Zhang Jian‐Ning , Duan Lian 
Published: July 2024

Background
This study investigated the long‐term clinical and angiographic outcomes of encephaloduroarteriosynangiosis treatment for symptomatic intracranial atherosclerotic arterial steno‐occlusive disease to further evaluate the potential therapeutic role of encephaloduroarteriosynangiosis in this population.

Methods and Results
A total of 152 adult patients with symptomatic intracranial atherosclerotic arterial steno‐occlusive disease who were treated with encephaloduroarteriosynangiosis and intensive medical management across 3 tertiary centers in China between January 2011 and September 2019 were retrospectively included. The primary outcomes were defined as postoperative cerebrovascular events, including ischemic and hemorrhagic stroke. The postoperative neovascularization was analyzed qualitatively and quantitatively by using angiography. Clinical, radiological, and long‐term follow‐up data were analyzed using Cox regression, logistic regression, and linear regression analyses. Primary outcome rates were 3.2% (5/152) within 30 days, 6.6% (10/152) within 2 years, 9.2% (14/152) within 5 years, and 11.1% (17/152) during a median 9.13 years follow‐up. Initial infarction symptoms were positively associated with recurrent ischemic stroke. Additionally, posterior circulation involvement and coexisting cardiac disease indicated poorer neurological status, whereas encephaloduroarteriosynangiosis neovascularization efficacy was negatively associated with older age and vascular risk factors but positively associated with posterior circulation involvement.

Conclusions
Encephaloduroarteriosynangiosis plus intensive medical management appears efficacious and safe for symptomatic intracranial atherosclerotic arterial steno‐occlusive disease, with low perioperative risk and favorable long‐term results. Further prospective trials are needed to verify its efficacy and determine the optimal patient selection criteria.
Estimated Pulse‐Wave Velocity and Magnetic Resonance Imaging Markers of Cerebral Small‐Vessel Disease in the NOMAS
Authors: Ariko Taylor A. , Aimagambetova Botagoz , Gardener Hannah , Gutierrez Jose , Elkind Mitchell S. V. , Wright Clinton B. , Zhao Weizhao , Rundek Tatjana 
Published: July 2024

Background
Pulse‐wave velocity is a measure of arterial stiffness and a risk factor for cardiovascular disease. Recently, an estimated pulse‐wave velocity (ePWV) was introduced that was predictive of increased risk of cardiovascular disease. Our objective was to determine whether ePWV was associated with cerebral small‐vessel disease on magnetic resonance imaging.

Methods and Results
We included 1257 participants from the NOMAS (Northern Manhattan Study). The ePWV values were calculated using a nonlinear function of age and mean arterial blood pressure. The association between ePWV and white matter hyperintensity volume was assessed. Modification by race and ethnicity was evaluated. Associations between ePWV and other cerebral small‐vessel disease markers, covert brain infarcts, cerebral microbleeds, and enlarged perivascular spaces, were explored as secondary outcomes. Mean±SD age of the cohort was 64±8 years; 61% were women; 18% self‐identified as non‐Hispanic Black, 67% as Hispanic, and 15% as non‐Hispanic White individuals. Mean±SD ePWV was 11±2 m/s in the total NOMAS population and was similar across race and ethnic groups. The ePWV was significantly associated with white matter hyperintensity volume (β=0.23 [95% CI, 0.20–0.26]) after adjustment. Race and ethnicity modified the association between ePWV and white matter hyperintensity volume, with stronger associations in Hispanic and non‐Hispanic Black individuals. Significant associations were found between ePWV and covert brain infarcts, cerebral microbleeds, and perivascular spaces after adjustment.

Conclusions
The ePWV function may provide a vascular mechanism for deleterious cerebrovascular outcomes in individuals with cerebral small‐vessel disease and is particularly apparent in the racial and ethnic minorities represented in the NOMAS cohort.