bluuebunny/crossref_metadata_2025_split huggingface dataset:
Automated tobacco assessment and cessation support for cancer patients
Authors: Warren Graham W. , Marshall James R. , Cummings K. Michael , Zevon Michael A. , Reed Robert , Hysert Pat , Mahoney Martin C. , Hyland Andrew J. , Nwogu Chukwumere , Demmy Todd , Dexter Elisabeth , Kelly Maureen , O'Connor Richard J. , Houstin Teresa , Jenkins Dana , Germain Pamela , Singh Anurag K. , Epstein Jennifer , Dobson Amato Katharine A. , Reid Mary E. 
Published: October 2013

BACKGROUNDTobacco assessment and cessation support are not routinely included in cancer care. An automated tobacco assessment and cessation program was developed to increase the delivery of tobacco cessation support for cancer patients.METHODSA structured tobacco assessment was incorporated into the electronic health record at Roswell Park Cancer Institute to identify tobacco use in cancer patients at diagnosis and during follow‐up. All patients who reported tobacco use within the past 30 days were automatically referred to a dedicated cessation program that provided cessation counseling. Data were analyzed for referral accuracy and interest in cessation support.RESULTSBetween October 2010 and December 2012, 11,868 patients were screened for tobacco use, and 2765 were identified as tobacco users and were referred to the cessation service. In referred patients, 1381 of those patients received only a mailed invitation to contact the cessation service, and 1384 received a mailing as well as telephone contact attempts from the cessation service. In the 1126 (81.4%) patients contacted by telephone, 51 (4.5%) reported no tobacco use within the past 30 days, 35 (3.1%) were medically unable to participate, and 30 (2.7%) declined participation. Of the 1381 patients who received only a mailed invitation, 16 (1.2%) contacted the cessation program for assistance. Three questions at initial consult and follow‐up generated over 98% of referrals. Tobacco assessment frequency every 4 weeks delayed referral in < 1% of patients.CONCLUSIONSAn automated electronic health record‐based tobacco assessment and cessation referral program can identify substantial numbers of smokers who are receptive to enrollment in a cessation support service. Cancer 2014;120:562–569. © 2013 American Cancer Society.
Autophagy and enhanced chemosensitivity in experimental pancreatic cancers induced by noninvasive radiofrequency field treatment
Authors: Koshkina Nadezhda V. , Briggs Katrina , Palalon Flavio , Curley Steven A. 
Published: October 2013

BACKGROUNDPatients with pancreatic ductal adenocarcinoma (PDAC) have limited therapeutic options and poor response to the standard gemcitabine (GCB)‐based chemotherapy. In the current study, the authors investigated the feasibility of noninvasive short‐wave radiofrequency (RF) electric fields to improve the cytotoxic effect of GCB on PDAC cells and determined its mechanism of action.METHODSThe cytotoxicity of RF alone and in combination with GCB was studied in vitro on normal pancreatic human pancreatic ductal epithelial cells and different PDAC cell lines by flow cytometry, and in vivo on ectopic and orthotopic human PDAC xenograft models in mice. The mechanism of RF activity was studied by Western blot analysis and immunohistochemistry. Toxicity was determined by histopathology.RESULTSExposure of different PDAC cells to 13.56‐megahertz radio waves resulted in a substantial cytotoxic effect, which was accompanied by the induction of autophagy but not apoptosis. These effects of RF were found to be absent in normal cells. Excessive numbers of autophagosomes in cancer cells persisted 24 to 48 hours after RF exposure and then declined. The addition of a subtoxic dose of GCB to RF treatment inhibited the recovery of cancer cells from the RF‐induced autophagy and enhanced the cytotoxic effect of the latter on cancer cells. The treatment of PDAC in situ in mice with the combination of noninvasive RF and GCB was found to have a superior antitumor effect compared with the use of RF or GCB alone, yet there was no evidence of systemic toxicity.CONCLUSIONSNoninvasive RF treatment induced autophagy but not apoptosis in cancer cells and demonstrated potential as an enhancer of chemotherapy for treating patients with pancreatic cancer without toxicity to normal cells. Cancer 2014;120:480–491. © 2013 American Cancer Society.
Distinct physiological and developmental properties of hippocampal CA2 subfield revealed by using anti‐Purkinje cell protein 4 (PCP4) immunostaining
Authors: San Antonio Andrew , Liban Kristopher , Ikrar Taruna , Tsyganovskiy Eugene , Xu Xiangmin 
Published: October 2013

ABSTRACTThe hippocampal CA2 subfield was initially identified by Lorente de Nó as an anatomically distinct region based on its cytoarchitectural features. Although there is an enormous body of literature on other hippocampal subfields (CA1 and CA3), relatively little is known about the physiological and developmental properties of CA2. Here we report identification of the CA2 region in the mouse by immunostaining with a Purkinje cell protein 4 (PCP4) antibody, which effectively delineates CA3/CA2 and CA2/CA1 borders and agrees well with previous cytoarchitectural definitions of CA2. The PCP4 immunostaining–delineated CA2 neurons have distinguishable differences in cell morphology, physiology, and synaptic circuit connections compared with distal CA3 and proximal CA1 regions. The average somatic sizes of excitatory cells differ across CA1–3, with the smallest to largest somatic size being CA1<CA2<CA3. CA2 excitatory cells have dense dendritic spines, but do not have thorny excrescences associated with bordering CA3 neurons. Photostimulation functional circuit mapping shows that CA2 excitatory neurons receives extensive synaptic input from CA3, but no detectable input from the dentate gyrus. CA2 excitatory cells also differ significantly from CA3 cells in intrinsic electrophysiological parameters, such as membrane capacitance and spiking rates. Although CA2 neurons differ from CA1 neurons for PCP4 and other marker expressions, these neurons have less distinct neurophysiological and morphological properties. Developmental examination revealed that PCP4 immunostaining first appears at postnatal day 4–5 and becomes successively more refined around CA2 until reaching adult form by postnatal day 21. J. Comp. Neurol. J. Comp. Neurol. 522:1333–1354, 2014. © 2013 Wiley Periodicals, Inc.
Hybrid biogeography based optimization for constrained optimal spot color matching
Authors: Lin Jian , Xu Li , Zhang Huiyuan 
Published: October 2013

AbstractBiogeography‐based optimization (BBO) is a new evolutionary algorithm which mimics the immigration and emigration of species among islands. Used widely in packaging and printing to obtain a colorful appearance, the spot color matching (SCM) is formulated as a complex multi‐dimensional optimization problem. In this article, BBO is combined with the harmony search (HS) and opposition‐based learning (OBL) approaches to construct an effective hybrid algorithm for solving the SCM problem. HS is used to enhance the local searching ability of BBO, and OBL is employed to increase the diversity of initial population; consequently, the exploration and exploitation abilities of the hybrid algorithm are enhanced and well balanced. Experiment results are presented to show the effectiveness of the proposed scheme. © 2013 Wiley Periodicals, Inc. Col Res Appl, 39, 607–615, 2014
Comparison of diagnostic accuracy between CellprepPlus® and ThinPrep® liquid‐based preparations in effusion cytology
Authors: Lee Yong‐Moon , Hwang Ji‐Yong , Son Seung‐Myoung , Choi Song‐Yi , Lee Ho‐Chang , Kim Eun‐Joong , Han Hye‐Suk , An Jin young , Han Joung‐Ho , Lee Ok‐Jun 
Published: October 2013

Liquid‐based cytology (LBC) is being increasingly used for body fluid specimens and has improved diagnostic accuracy when compared to conventional smears. We compared the diagnostic accuracy and cellular morphologic features between CellprepPlus® LBC and ThinPrep® LBC in effusion cytology.One hundred and eighty body fluid specimens, consisting of 119 pleural fluid specimens, 59 peritoneal fluid specimens, and 2 pericardial fluid specimens, were obtained from 166 patients. Equal volumes of body fluid from each specimen were used in the CellprepPlus® and ThinPrep® preparations. Sensitivity, specificity, and positive and negative predictive values were evaluated. In addition, we selected 16 specimens from patients with metastatic adenocarcinoma, confirmed them by both LBC preparations, and measured the size of the nucleus in the tumor cells in these specimens.The sensitivity of the CellprepPlus® and ThinPrep® methods was 73.1% and 50.0%, respectively. The specificity and positive predictive values were 100% for both LBC methods, and the negative predictive values of the CellprepPlus® and ThinPrep® methods were 90.9% and 83.3%, respectively. The average nuclear size of the tumor cells was calculated as 20.87 μm using the CellprepPlus® method and 15.08 μm using the ThinPrep® method (P < 0.05).The CellprepPlus® method provided better diagnostic accuracy of effusion cytology compared to the ThinPrep® method and revealed the characteristic morphological features of tumor cells, including large and hypochromatic nuclei, prominent nucleoli, distinct nuclear membranes, and high cellularity. Diagn. Cytopathol. 2014;42:384–390. © 2013 Wiley Periodicals, Inc.
Inconclusive or erroneous fine‐needle aspirates of breast with adequate and representative material: A cytologic/histologic study
Authors: Shabb Nina S. , Boulos Fouad I. , Chakhachiro Zaher , Abbas Jaber , Abdul‐Karim Fadi W. 
Published: October 2013

Adequately cellular and representative fine‐needle aspirates (FNAs) of breast have a high diagnostic accuracy. There is, however, a recognized category designated as “gray zone” where a definitive diagnosis cannot be reached. We reviewed our experience in this category to identify useful diagnostic parameters.Twenty‐four such FNAs with surgical follow‐up were retrieved from AUBMC files (2003–2009). Cytology slides were reviewed blindly.All cases were females, 29–73 years. There were three erroneous and 21 inconclusive diagnoses. The majority (15) was invasive adenocarcinomas: two cribriform, four tubular, one lobular, and eight not otherwise specified. The remaining cases were papillary and fibroepithelial tumors (three each), ductal carcinoma in situ, cribriform (two), and one adenomyoepithelioma (AME). Useful diagnostic features included: (1) Biphasic cell population with focal nuclear atypia and intranuclear and cytoplasmic vacuolar inclusions (AME). (2) Complex clusters of epithelial cells with cribriform architecture (cribriform carcinoma). (3) Rigid tubular epithelial structures with abrupt change in diameter, ending in pointed tips with abnormal branching (tubular carcinoma). (4) Cellular stromal fragments (fibroepithelial tumors). (5) Papillary fibrovascular cores, columnar cells, and three‐dimensional papillary epithelial fragments (papillary tumors). Myoepithelial cells classically described in benign aspirates were not always a discriminatory factor.The “gray zone” in breast FNA is usually due to overlapping cytologic features of some benign and malignant lesions. Useful distinguishing cytologic features are described. Diagn. Cytopathol 2014;42:405–415. © 2013 Wiley Periodicals, Inc.
Morphological divergence and flow‐induced phenotypic plasticity in a native fish from anthropogenically altered stream habitats
Authors: Franssen Nathan R. , Stewart Laura K. , Schaefer Jacob F. 
Published: October 2013

AbstractUnderstanding population‐level responses to human‐induced changes to habitats can elucidate the evolutionary consequences of rapid habitat alteration. Reservoirs constructed on streams expose stream fishes to novel selective pressures in these habitats. Assessing the drivers of trait divergence facilitated by these habitats will help identify evolutionary and ecological consequences of reservoir habitats. We tested for morphological divergence in a stream fish that occupies both stream and reservoir habitats. To assess contributions of genetic‐level differences and phenotypic plasticity induced by flow variation, we spawned and reared individuals from both habitats types in flow and no flow conditions. Body shape significantly and consistently diverged in reservoir habitats compared with streams; individuals from reservoirs were shallower bodied with smaller heads compared with individuals from streams. Significant population‐level differences in morphology persisted in offspring but morphological variation compared with field‐collected individuals was limited to the head region. Populations demonstrated dissimilar flow‐induced phenotypic plasticity when reared under flow, but phenotypic plasticity in response to flow variation was an unlikely explanation for observed phenotypic divergence in the field. Our results, together with previous investigations, suggest the environmental conditions currently thought to drive morphological change in reservoirs (i.e., predation and flow regimes) may not be the sole drivers of phenotypic change.
Review of Oxygen Carriers for Chemical Looping with Oxygen Uncoupling (CLOU): Thermodynamics, Material Development, and Synthesis
Authors: Imtiaz Qasim , Hosseini Davood , Müller Christoph Rüdiger 
Published: October 2013

AbstractGlobal warming and climate change are most likely linked to the increasing concentration of the greenhouse gas carbon dioxide (CO2) in the atmosphere. Additionally, the consumption of fossil fuels is predicted further to increase in the coming decades, particularly due to the rapid development of populous countries such as Brazil, India, and China. Therefore, it is imperative to develop and implement processes that avoid the emission of anthropogenic CO2. One possible midterm solution is carbon‐dioxide capture and storage (CCS). In this context, the so‐called chemical‐looping combustion (CLC) process, that is, an emerging 3rd‐generation CCS technology, is particularly attractive due to its very low predicted CO2‐capture costs compared to the currently available technology (i.e., amine scrubbing). In CLC, lattice oxygen from a solid‐state oxygen carrier is used to combust a hydrocarbon fuel, which yields, after the condensation of steam, a pure stream of CO2 suitable for sequestration. To allow the application of CLC to solid fuels, chemical looping with oxygen uncoupling (CLOU) has been proposed. Here molecular oxygen is provided by using the decomposition reaction of the oxygen carrier, thus, effectively the solid fuel is combusted in an oxyfuel mode. Importantly, a cornerstone of the CLOU process is the development of suitable oxygen carriers. In the first part of the review we discuss the thermodynamic properties of various CLOU materials. Subsequently, recent advances in the development of novel oxygen carriers are summarized. In particular, we focus on the physical and chemical properties of the new materials and the synthesis strategies employed. The review is concluded with an outlook on the CLOU process.
Strategies for Developing Prediction Models From Genome‐Wide Association Studies
Authors: Wu Jincao , Pfeiffer Ruth M. , Gail Mitchell H. 
Published: October 2013

AbstractGenome‐wide association studies (GWASs) have identified hundreds of single nucleotide polymorphisms (SNPs) associated with complex human diseases. However, risk prediction models based on them have limited discriminatory accuracy. It has been suggested that including many such SNPs can improve predictive performance. Here, we studied various aspects of model building to improve discriminatory accuracy, as measured by the area under the receiver operating characteristic curve (AUC), including: (1) How well does a one‐phase procedure that selects SNPs and estimates odds ratios on the same data perform? (2) How should training data be allocated between SNP selection (Phase 1) and estimation (Phase 2) in a two‐phase procedure? (3) Should SNP selection be based on P‐value thresholding or ranking P‐values? (4) How many SNPs should be selected? and (5) Is multivariate estimation preferred to univariate estimation in the presence of linkage disequilibrium (LD)? We used realistic estimates of the distributions of genetic effect sizes, allele frequencies, and LD patterns based on GWAS data for Crohn's disease and prostate cancer. Theory and simulations were used to estimate AUC. Empirical risk models based on 10,000 cases and controls had considerably lower AUC than theoretically achievable. The most critical aspect of prediction model building was initial SNP selection. The single‐phase procedure achieved higher AUC than the two‐phase procedure. Multivariate estimation did not perform as well as univariate (marginal) estimation. For complex diseases and samples of 10,000 or fewer cases and controls, one should limit the number of SNPs to tens or hundreds.
Are Physicians' Prescribing Decisions Sensitive to Drug Prices? Evidence from a Free‐antibiotics Program
Authors: Li Shanjun , Laxminarayan Ramanan 
Published: October 2013

AbstractThis paper investigates whether patient‐level factors, in particular cost considerations, affect the physicians' prescribing decisions. In the context of a natural experiment, we examine the effect of the first US commercial free‐antibiotics program on retail antibiotic sales. We find an overall increase in antibiotic prescriptions under the program and substitutions to covered antibiotics from not‐covered antibiotics. The shift away from not‐covered antibiotics, particularly from those without covered equivalents, indicates a change in the physicians' prescribing decisions. We locate stronger program effects in low‐income areas. Our findings, robust to a variety of specifications, are in contrast with previous literature. Copyright © 2013 John Wiley & Sons, Ltd.
Phase II trial of biweekly gemcitabine and paclitaxel with recurrent or metastatic squamous cell carcinoma of the head and neck: Southwest Oncology Group study S0329
Authors: Malhotra Binu , Moon James , Kucuk Omar , Clark Joseph I. , Urba Susan G. , Wolf Gregory T. , Worden Francis P. 
Published: October 2013

AbstractBackgroundA phase I study and an institutional pilot study in patients with metastatic/recurrent squamous cell carcinoma of the head and neck (SCCHN) utilizing biweekly gemcitabine and paclitaxel (GEMTAX), showed an overall response rate of 53%. 1 This phase II trial was conducted to determine the feasibility, tolerability, and efficacy of this combination.MethodsPatients with metastatic/recurrent SCCHN were treated with gemcitabine (3000 mg/m2) and paclitaxel (150 mg/m2) on days 1 and 15 of every 28‐day cycle.ResultsIn 57 patients with measurable disease, median progression‐free survival (PFS) was 4 months and median overall survival (OS) was 8 months. Overall response rate of 28% and disease stabilization in 19% were seen. There were no treatment‐related deaths with grade 3/4 hematologic toxicity seen in 20% of the patients.ConclusionBiweekly GEMTAX is feasible, well tolerated, and demonstrated reasonable efficacy. This may be an alternative for patients who are not candidates for platinum‐based chemotherapy. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1712–1717, 2014
Diagnostic evaluation of sentinel lymph node biopsy in early head and neck squamous cell carcinoma: A meta‐analysis
Authors: Yamauchi Kohichi , Kogashiwa Yasunao , Nakamura Takehiro , Moro Yorihisa , Nagafuji Hiroshi , Kohno Naoyuki 
Published: October 2013

AbstractBackgroundThe purpose of this study was to evaluate the efficacy of sentinel lymph node biopsy (SLNB) in early head and neck squamous cell carcinoma (HNSCC).MethodsThe PubMed database was searched for studies published before October 31, 2012. Pooled values for the sentinel lymph node identification rate, sensitivity, false‐negative rate, negative predictive value, and accuracy were calculated.ResultsA total of 16 studies (987 patients) was included. The pooled identification rate, sensitivity, false‐negative rate, negative predictive value, and accuracy were 95.2%, 86.3%, 13.7%, 94.2%, and 95.0%, respectively. The subgroup with high methodological quality showed a mean identification rate of 95.4% for SLNB validation trials and 94.2% for SLNB alone trials, and mean sensitivity of 91.0% for SLNB validation trials and 84.2% for SLNB alone trials.ConclusionThe SLNB procedure has shown a high sensitivity rate, but the pooled sensitivity and false‐negative rate were worse in SLNB alone trials than in SLNB validation trials. © 2014 Wiley Periodicals, Inc. Head Neck 37: 127–133, 2015
Relationship between onset of hypocalcemic symptoms and the recovery time from transient hypocalcemia after total thyroidectomy
Authors: Lee Yong Sang , Chang Hang‐Seok , Chung Woong Youn , Nam Kee‐Hyun , Park Cheong Soo 
Published: October 2013

ABSTRACTBackgroundThe purpose of this study was to examine whether the time required for recovery from transient hypoparathyroidism is correlated with the onset of hypocalcemic symptoms in patients with total thyroidectomy.MethodsMedical records of 54 patients were retrospectively reviewed. The correlation between the onset of hypocalcemic symptoms and the recovery time were compared for all patients divided into 3 groups based on first appearance of hypocalcemic symptoms; group 1, onset within 24 hours; group 2, onset at 24 to 48 hours; and group 3, onset >48 hours.ResultsThere was a negative correlation between onset and recovery times (p < .001). Serum parathyroid hormone levels 1 year after surgery were significantly lower in group 1 than in groups 2 or 3 (p < .001).ConclusionRecovery time can be predicted by time of onset of hypocalcemic symptoms and signs. Earlier onset leads to longer recovery times. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1732–1736, 2014
Spatial discrimination deficits as a function of mnemonic interference in aged adults with and without memory impairment
Authors: Reagh Zachariah M. , Roberts Jared M. , Ly Maria , DiProspero Natalie , Murray Elizabeth , Yassa Michael A. 
Published: October 2013

ABSTRACTIt is well established that aging is associated with declines in episodic memory. In recent years, an emphasis has emerged on the development of behavioral tasks and the identification of biomarkers that are predictive of cognitive decline in healthy as well as pathological aging. Here, we describe a memory task designed to assess the accuracy of discrimination ability for the locations of objects. Object locations were initially encoded incidentally, and appeared in a single space against a 5 × 7 grid. During retrieval, subjects viewed repeated object‐location pairings, displacements of 1, 2, 3, or 4 grid spaces, and maximal corner‐to‐opposite‐corner displacements. Subjects were tasked with judging objects in this second viewing as having retained their original location, or having moved. Performance on a task such as this is thought to rely on the capacity of the individual to perform hippocampus‐mediated pattern separation. We report a performance deficit associated with a physically healthy aged group compared to young adults specific to trials with low mnemonic interference. Additionally, for aged adults, performance on the task was correlated with performance on the delayed recall portion of the Rey Auditory Verbal Learning Test (RAVLT), a neuropsychological test sensitive to hippocampal dysfunction. In line with prior work, dividing the aged group into unimpaired and impaired subgroups based on RAVLT Delayed Recall scores yielded clearly distinguishable patterns of performance, with the former subgroup performing comparably to young adults, and the latter subgroup showing generally impaired memory performance even with minimal interference. This study builds on existing tasks used in the field, and contributes a novel paradigm for differentiation of healthy from possible pathological aging, and may thus provide an avenue for early detection of age‐related cognitive decline. © 2013 Wiley Periodicals, Inc.