bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dropped head syndrome suspected due to oxaliplatin used in adjuvant chemotherapy for gastric cancer: a case report
Authors: Marunaka Yuta , Ohashi Takuma , Kubota Takeshi , Nishibeppu Keiji , Konishi Hirotaka , Shiozaki Atsushi , Fujiwara Hitoshi , Otsuji Eigo 
Published: July 2024

Abstract
Background
Dropped head syndrome (DHS) is caused by dysfunction of the cervical musculature. It is classified into two groups according to the cause: one is weakness of the neck extensors and the other is hypercontraction of the cervical flexors associated with Parkinson’s disease and other disorders. Although some drugs have previously been reported as suspected causes of DHS, we are unaware of any reports in which oxaliplatin was suspected. In this report, we describe a case of DHS during adjuvant chemotherapy for gastric cancer, along with a review of the relevant literature.

Case presentation
A 72-year-old man was diagnosed with gastric cancer, cT3N0M0 cStage IIB, and underwent laparoscopic total gastrectomy with D2 lymphnode dissection and Roux-en-Y reconstruction. The operative time was 311 min, intraoperative blood loss was 40 g, and he was discharged without any post-operative complications. The histopathological diagnosis was pT4aN2M0 pStage IIIA, and S-1 + oxaliplatin (SOX) therapy was started as adjuvant chemotherapy. On the 4th course of SOX, he complained of neck heaviness and a blood test revealed that his creatine kinase (CK) level was elevated to 2464 IU/L. After consultation with an orthopedic surgeon and a neurologist, DHS due to localized cervical extensor myositis was suspected. Therefore, the 6th course of SOX was postponed, and 30 mg of oral steroids were initiated. His symptoms improved, and his CK level decreased within 2 weeks. After resuming S-1 monotherapy and tapering off oral steroids, no recurrence of symptoms has been observed.

Conclusions
We experienced one case of DHS during adjuvant chemotherapy for gastric cancer. If DHS develops after starting oxaliplatin, involvement of the drug should be suspected, and discontinuation of chemotherapy and introduction of oral steroids should be considered.
Preoperative forced expiratory volume in one second and postoperative respiratory outcomes in nonpulmonary and noncardiac surgery: a retrospective cohort study
Authors: Mizota Toshiyuki , Hamada Miho , Hirotsu Akiko , Dong Li , Matsukawa Shino , Takeda Chikashi , Egi Moritoki 
Published: July 2024

Abstract
Background
Although the usefulness of pulmonary function tests has been established for lung resection and coronary artery bypass surgeries, the association between preoperative pulmonary function test and postoperative respiratory complications in nonpulmonary and noncardiac surgery is inconclusive. The purpose of this study was to determine the association between preoperative forced expiratory volume in one second (FEV1) on pulmonary function test and the development of postoperative respiratory failure and/or death in patients undergoing major nonpulmonary and noncardiac surgery.

Methods
Adult patients aged ≥ 18 years and who underwent nonpulmonary and noncardiac surgery with expected moderate to high risk of perioperative complications from June 2012 to March 2019 were included. The primary exposure was preoperative FEV1 measured by pulmonary function test within six months before surgery. The primary outcome was respiratory failure (i.e., invasive positive pressure ventilation for at least 24 h after surgery or reintubation) and/or death within 30 days after surgery. A logistic regression model was used to adjust for the respiratory failure risk index, which is a scoring system that predicts the probability of postoperative respiratory failure based on patient and surgical factors, and to examine the association between preoperative FEV1 and the development of postoperative respiratory failure and/or death.

Results
Respiratory failure and/or death occurred within 30 days after surgery in 52 (0.9%) of 5562 participants. The incidence of respiratory failure and/or death in patients with FEV1 ≥ 80%, 70%– < 80%, 60%– < 70%, and < 60% was 0.9%, 0.6%, 1.7%, and 1.2%, respectively. Multivariable logistic regression analysis showed no significant association between preoperative FEV1 and postoperative respiratory failure and/or death (adjusted odds ratio per 10% decrease in FEV1: 1.01, 95% confidence interval: 0.88–1.17, P = 0.838). Addition of FEV1 information to the respiratory failure risk index did not improve the prediction of respiratory failure and/or death [area under the receiver operating characteristics curve: 0.78 (95% confidence interval: 0.72–0.84) and 0.78 (95% confidence interval: 0.72–0.84), respectively; P = 0.84].

Conclusion
We found no association between preoperative FEV1 and postoperative respiratory failure and/or death in patients undergoing major nonpulmonary and noncardiac surgery.
Relationship between night eating syndrome and sleep quality among university students in Palestine
Authors: Alwafa Reem Abu , Jallad Samar , Al-Sheikh Razan Abu , Adwan Raghad , Badrasawi Manal 
Published: July 2024

Abstract
Background
Night eating syndrome (NES) is an eating disorder in which at least one-third of one’s daily caloric intake is consumed after the last meal of the day or throughout the nocturnal evening on at least two consecutive occasions each week. In the literature, the prevalence of NES among university students ranged from 4.2 to 15%.

Aim
The purpose of this study was to find out how common NES is among Palestinian university students, as well as the association between NES, sleep quality, BMI, socioeconomic factors, and lifestyle factors.

Methods
Students from An-Najah National University completed an online questionnaire. The Pittsburgh Sleep Quality Index (PSQI) and the Eating Questionnaire (NEQ) were employed.

Results
A total of 333 participants took part in the study. The average age of the participants was 21.66 years (range: 16 to 33). The presence of NES was identified in 82.6% of the study subjects. There was no evidence of a link between NES and BMI, sociodemographic variables, or lifestyle factors. Higher scores on subjective sleep quality (p < .01), sleep latency (p < .01), and daytime dysfunction (p < .05) scores were found to be linked with NES. Additional to this, the NEQ scores were shown to be substantially connected with these scores, as well as the sleep duration scores (p < .05). Subjective sleep quality (p < .01) and sleep latency (p < .01) were revealed to be significant predictors of the NEQ score.

Conclusion
NES was significantly related to sleep quality subscales among Palestinian university students. Moreover, subjective sleep quality and sleep latency predicted NEQ score.
Oncoplastic Breast-Conserving Surgery in African Women: A Systematic Review
Authors: Adesunkanmi Abdulhafiz Oladapo , Wuraola Funmilola Olanike , Fagbayimu Oluwatobiloba Michael , Calcuttawala Murtuza Aliasger , Wahab Tajudeen , Adisa Adewale Oluseye 
Published: July 2024

PURPOSE Breast cancer is the most frequently diagnosed cancer in women worldwide. Surgery is a major treatment modality for breast cancer, and over the years, breast-conserving surgeries with breast radiation have shown similar outcomes with mastectomy. Not much is known about the frequency and outcome of breast-conserving surgery in Africa. This systematic review provides a comprehensive summary of the evidence evaluating cosmetic and oncologic outcomes after oncoplastic breast-conserving surgery (OBCS) for breast cancer in African women. METHODS This review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses statement. Databases were systematically searched for studies on African women undergoing OBCS. The oncologic and cosmetic outcomes, as well as the localization and reconstruction techniques, were evaluated. Descriptive statistics were used to summarize the frequency and proportions of the extracted variables. RESULTS The literature search yielded 266 articles but only 26 of these were included in the review. Majority of the studies were from Egypt and South Africa. These studies collectively evaluated 1,896 patients with a mean age of 48.2 years and a mean follow-up period of 36.9 months. The most common histopathology was T2 (71.4%) invasive ductal carcinoma. Hook wire localization was the most common technique used for nonpalpable lesions in 85.3% of patients. Of the studies reporting oncoplastic technique, the latissimus dorsi volume replacement technique was the most reported (15%). Most patients were satisfied with their cosmetic outcome. Seroma was the most common postoperative complication (44.6%). Among studies that reported oncologic outcome data, the crude overall survival and disease-free survival were 93.1% and 89.4%, respectively. CONCLUSION This systematic review revealed that the outcome of OBCS in African women compares with that in developed countries.
Patterns of Survivorship Follow-Up Care Among Patients With Breast Cancer: A Retrospective Population-Based Cohort Study in Ontario, Canada, Between 2006 and 2016
Authors: Sussman Jonathan , Cerasuolo Joshua O. , Pond Gregory R. , Bainbridge Daryl , Seow Hsien 
Published: July 2024

PURPOSE
Many cancer survivors have ongoing follow-up with their oncologist(s), despite evidence that this care can be competently managed by primary care and transitioning well survivors could relieve growing pressure on cancer care systems. We analyzed population-based administrative data from Ontario, Canada, to examine rates of transition to primary care–led follow-up care during the survivorship phase, including clinical and demographic predictors associated with being transitioned.

METHODS
We conducted a retrospective cohort study to describe the patterns of survivorship follow-up care among all patients with breast cancer in Ontario from 2006 to 2016. Data were derived from the Ontario Cancer Registry and other linked data sets. We defined the survivorship phase of care beginning at 2 years after initial diagnosis. Logistic regression was used to explore factors potentially prognostic of no oncology visits in each of the years after survivorship.

RESULTS
Our survivorship cohort was composed of 71,719 patients with breast cancer, 42% of whom were considered to have transitioned from oncology to primary care 2 years after diagnosis. Although the number of patients having oncology visits diminished over time, a quarter of the cohort continued being seen in year 5 of survivorship. Regression analysis found older age, early cancer stage, living farther from a cancer center, not receiving radiation or chemotherapy, and high well-being to be associated with transitioning to primary care.

CONCLUSION
Our findings contribute to the development of low-risk profiles among survivors to inform optimal transition from oncology to primary care. Further research examining qualitative perspectives from oncologists, cancer survivors, and primary care is also required to illuminate other sentinel factors to be considered when transitioning during follow-up.
Imbalance polarization of M1/M2 macrophages in miscarried uterus
Authors: Feng Jun , Gao Ping , Wu Ting , Hou Wenjie , Zhang Yueming , Li Lili 
Published: July 2024

Background
Lipopolysaccharides (LPS) is well known to manifest a miscarriage-inducing effector during early pregnancy and activate macrophage to induce M1 macrophage polarization. However, the role of macrophage polarization in LPS-related miscarriage-inducing effect is not apparent.

Methods
In this work, gene expression changes and the percentage of M1/M2 macrophages and monocytes in LPS-induced miscarried uterus were firstly analyzed by RNA sequencing (RNA-seq) and Flow Cytometry. To explore the origin that contributes to M1/M2 macrophage differentiation, the expression of monocyte chemotactic protein (MCP-1), CCL3, and CCL4, chemokines related to monocyte/macrophage migration, was tested by quantitative real time PCR (qRT-PCR).

Results
We found that percentage of M1 macrophages rose, while the percentage of M2 macrophages declined down in the injected mice uterus. Meanwhile, the percentage of M1 and M2 macrophages showed no significant difference in the spleens of LPS injected mice compared to PBS injected control mice. Expression of Mcp-1, Ccl3, and Ccl4 and numbers of monocytes were remarkably up-regulated in LPS-induced miscarried mice uterus.

Conclusion
These results indicated that polarization and proportion changes of macrophage in the uterus may contribute to miscarriage. Our work provides new evidence correlating the aberrant regulation of M1/M2 macrophage polarization with deleterious miscarriage-inducing effects. This will help us understand the roles of critical immune cell differentiation in maintaining normal pregnancy.
Analysis of the effect of motion on highly accelerated 3D FatNavs in 3D brain images acquired at 3T
Authors: Marchetto Elisa , Gallichan Daniel 
Published: July 2024

Purpose
3D FatNavs are rapid acquisitions of MRI fat-volumes within the head that can be used for retrospective motion correction for brain MRI. 3D FatNavs typically use very high acceleration factors and are reconstructed with the GRAPPA parallel imaging technique. However, the GRAPPA reconstruction is not expected to perform well on 3D FatNavs volumes in the presence of strong motion due to the mismatched calibration data acquired once at the start of the scan, leading to motion-parameter misestimation. This study aims to assess the accuracy and precision of 3D FatNav-derived motion-estimates in the presence of large changes in head position.

Methods
Rigid motion parameters were simulated and applied retrospectively to the 3D FatNav volumes from MPRAGE datasets acquired at 3T. The transformed images were then re-reconstructed using GRAPPA to simulate real motion deterioration of the fat-navigator, and used to estimate the motion applied and evaluate the tracking inaccuracy. This information was then used to estimate the residual motion after 3D FatNav-based motion correction and applied to the original MPRAGE volumes. The effect of the misestimation was assessed using an image quality metric and the evaluation scores from two observers. Quality boundaries were then estimated to assess the motion tolerance when 3D FatNavs are used.

Results
The GRAPPA reconstruction was shown to deteriorate for large changes in the head position, affecting the quality of 3D FatNav volumes and consequently degrading the accuracy of the motion-estimates. Based on our simulations, the estimated threshold of motion that led to a noticeable degradation in the MPRAGE image quality was up to RMS values of 3.7° and 3 mm for rotations and translations respectively.

Conclusions
3D FatNavs were shown to be able to correct for a wide range of motion levels and types. Boundaries of acceptable motion magnitudes for different levels of acceptable loss of image quality were determined.
Anxiety and depression symptoms among a sample of Khartoum civilians during the 2023 Sudan armed conflict: A cross-sectional study
Authors: M. Ahmed Ahmed Balla , Yeddi Ahmed A. , Alrawa Salma S. , Alfadul Esraa S. A. 
Published: July 2024

Background
Mental health during armed conflicts is of paramount importance, as such situations often lead to increased risks of anxiety and depression symptoms among civilians. The military conflict between the Sudanese army and Rapid Support Forces, which began on April 15, 2023, is currently ongoing mainly in Khartoum State. Despite the significant impact of the conflict on the region, there is a lack of data regarding the mental health status of the residents. The aim of this study is to assess anxiety and depression symptoms among residents of Khartoum State during the first months of the 2023 military conflict.

Method
We conducted a cross-sectional study among residents of Khartoum State between May 27 and June 19 using an online questionnaire. We used standardized screening questionnaires, namely the Generalized Anxiety Disorder (GAD-7) for anxiety and the Patient Health Questionnaire (PHQ-9) for depression. Multiple logistic regression was used to identify sociodemographic factors that are associated with anxiety and depression symptoms.

Results
Out of the 393 participants in the study, 70% had symptoms suggestive of depression and 57.3% suffered from anxiety symptoms. Both anxiety and depression were associated with being female (p < 0.001). Being married was a predictor of anxiety (p = 0.028) but not depression (p = 0.3). Other predictors were not significant (p > 0.05).

Conclusion
High levels of anxiety and depression symptoms were prevalent among Khartoum residents during the conflict, with females and married individuals at higher risk. Immediate medical assessment is essential for identifying cases and providing support. Mental health services should be integrated into emergency response efforts, particularly focusing on vulnerable groups. Future research should address study limitations and explore coping strategies for anxiety and depression in Sudanese adults.
Stationary measures for SL2(ℝ)-actions on homogeneous bundles over flag varieties
Authors: Gorodnik Alexander , Li Jialun , Sert Cagri 
Published: July 2024

Abstract
Let 𝐺 be a real semisimple Lie group with finite centre and without compact factors,

Q
<
G

Q<G

a parabolic subgroup and 𝑋 a homogeneous space of 𝐺 admitting an equivariant projection on the flag variety

G
/
Q

G/Q

with fibres given by copies of lattice quotients of a semisimple factor of 𝑄.
Given a probability measure 𝜇, Zariski-dense in a copy of

H
=

SL
2

⁡

(
R
)

H=\operatorname{SL}_{2}(\mathbb{R})

in 𝐺, we give a description of 𝜇-stationary probability measures on 𝑋 and prove corresponding equidistribution results.
Contrary to the results of Benoist–Quint corresponding to the case

G
=
Q

G=Q

, the type of stationary measures that 𝜇 admits depends strongly on the position of 𝐻 relative to 𝑄.
We describe possible cases and treat all but one of them, among others using ideas from the works of Eskin–Mirzakhani and Eskin–Lindenstrauss.
Extremal functions for twisted sharp Sobolev inequalities with lower order remainder terms. The high-dimensional case
Authors: Druet Olivier , Hebey Emmanuel , Robert Frédéric 
Published: July 2024

Abstract
We prove existence of extremal functions and compactness of the set of extremal functions for twisted sharp 𝑛-dimensional Sobolev inequalities with lower order remainder terms when

n
≥
5

n\geq 5

.
Comparison of modeling methods for the effective diffusivities of IO3
− estimated in compacted bentonite using through-diffusion tests under aerobic conditions
Authors: Tsai Tsuey-Lin , Tsai Shih-Chin 
Published: July 2024

Abstract
Diffusion is the predominant mechanism governing the transport of 129I through geosphere. Consequently, the assessment of the experimental findings on two-compartment diffusion reservoirs of IO3
− within compacted bentonite involved the application of three distinct diffusion models: CC–CC (constant concentration), CC–VC (variable concentration), and VC–VC. To ensure the reliability of the obtained diffusion coefficients, multiple laboratory tests were performed for internal comparison. The experimental results revealed that IO3
− diffusion coefficients were ranging from 3.83 × 10−13 to 1.91 × 10−11  m2/s. These techniques using three mathematical models could be conducted to estimate the diffusion coefficients of non- or weakly-sorbing radionuclides on compacted bentonite for safety assessment of radioactive waste final disposal.
Comparison of the ability of newly inflammatory markers to predict complicated appendicitis
Authors: Saridas Ali , Vural Nafis , Duyan Murat , Guven Hasan Can , Ertas Elif , Cander Basar 
Published: July 2024

Abstract

Introduction
Acute appendicitis (AA) is the predominant condition responsible for acute abdominal pain across all age demographics. The purpose of this research is to determine if the hemoglobin, albumin, lymphocyte, and platelet (HALP) and modified HALP (m-HALP) scores differ between complicated and uncomplicated appendicitis in patients diagnosed with AA who have applied to the emergency department (ED). Additionally, this study aims to investigate whether HALP and m-HALP scores are superior to other biomarkers.

Materials and methods
The retrospective analysis included adult patients, aged eighteen or older, who were diagnosed with AA, and sought treatment at the ED of a tertiary hospital. Patients were divided into two groups: complicated appendicitis (CA) and uncomplicated appendicitis (UCA). The cut-off in diagnostic value measurements was determined using the receiver operating characteristic analysis.

Results
A total of 436 patients (CA: 126, UCA: 310) were included. Neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-albumin ratio, systemic immune-inflammation index (SII), systemic inflammation response index (SIRI), and pan-immune inflammation value (PIV) were found to have acceptable diagnostic power in CA detection (area under the curve [AUC]: 0.735–0.783). In detecting UCA, HALP and m-HALP were of fair diagnostic power (AUC: 0.64, 0.68, respectively).

Conclusions
In this study, we found that although PIV, SIRI, SII, and NLR had acceptable diagnostic values in distinguishing CA and UCA, HALP and m-HALP had fair diagnostic values.
A novel method for constructing large-scale industrial noise maps based on open source data
Authors: Wang Yubin , Lee Hsiao Mun 
Published: July 2024

Abstract
This study proposed a method of obtaining the type and quantity of equipment in factories by inquiring environmental impact assessment reports, which greatly improves the efficiency of gathering factory information. Thereafter, by combining on-site measurement and numerical modelling, the noise maps of an automobile industrial area were constructed. The exposed population under different noise levels were evaluated using the noise maps. The results indicated that noise pollution at nighttime in the study area was more severe than that during daytime, with 523 people (1.08%) and 1,357 people (2.81%) exposed to excessive noise levels during daytime and nighttime, respectively. In addition, this study also constructed a low-frequency industrial noise map. The methods and results of the present study can provide novel technical path for construction and analysis of large-scale industrial noise map.
Effect of the gravitational field strength on the rate of chemical reactions
Authors: Wasif Baig Mirza 
Published: July 2024

Abstract
The magnitude of the rate of chemical reactions also depends on the position in the gravitational field where a chemical reaction is being carried out. The rate of chemical reaction conducted at a stronger gravitational field, i.e., near the surface of some heavy planet, is slower than the rate of reaction conducted at a weaker gravitational field, i.e., away from the surface of a heavy plant, provided temperature and pressure are kept constant at two positions in the gravitational field. The effect of gravity on the rates of reactions has been shown by formulating the rate constants from almost all types of reaction rate theories, i.e., transition state theory, collision theory, Rice–Ramsperger–Kassel–Marcus, and Marcus’s theory, in the language of the general theory of relativity. The gravitational transformation of the Boltzmann constant and the energy quantum levels of molecules have been developed quantum mechanically. A gravitational transformation of thermodynamic state functions has been formulated that successfully explains the quasi-equilibrium existing between reactants and the activated complex at different gravitational fields. Gravitational mass dilation has been developed, which explains that at weaker gravitational fields, the transition states possess more kinetic energy to sweep translation on the reaction coordinate, resulting in the faster conversion of reactants into products. The gravitational transformation of the half-life equation shows gravitational time dilation for the half-life period of chemical reactions and thus renders the general theory of relativity and the present theory in accord with each other.