bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accelerated cardiac magnetic resonance imaging using deep learning for volumetric assessment in children
Authors: Koechli Melina , Callaghan Fraser M. , Burkhardt Barbara E. U. , Lohézic Maélène , Zhu Xucheng , Rücker Beate , Valsangiacomo Buechel Emanuela R. , Kellenberger Christian J. , Geiger Julia 
Published: July 2024

Abstract
Background
Ventricular volumetry using a short-axis stack of two-dimensional (D) cine balanced steady-state free precession (bSSFP) sequences is crucial in any cardiac magnetic resonance imaging (MRI) examination. This task becomes particularly challenging in children due to multiple breath-holds.

Objective
To assess the diagnostic performance of accelerated 3-RR cine MRI sequences using deep learning reconstruction compared with standard 2-D cine bSSFP sequences.

Material and methods
Twenty-nine consecutive patients (mean age 11 ± 5, median 12, range 1–17 years) undergoing cardiac MRI were scanned with a conventional segmented 2-D cine and a deep learning accelerated cine (three heartbeats) acquisition on a 1.5-tesla scanner. Short-axis volumetrics were performed (semi-)automatically in both datasets retrospectively by two experienced readers who visually assessed image quality employing a 4-point grading scale. Scan times and image quality were compared using the Wilcoxon rank-sum test. Volumetrics were assessed with linear regression and Bland–Altman analyses, and measurement agreement with intraclass correlation coefficient (ICC).

Results
Mean acquisition time was significantly reduced with the 3-RR deep learning cine compared to the standard cine sequence (45.5 ± 13.8 s vs. 218.3 ± 44.8 s; P < 0.001). No significant differences in biventricular volumetrics were found. Left ventricular (LV) mass was increased in the deep learning cine compared with the standard cine sequence (71.4 ± 33.1 g vs. 69.9 ± 32.5 g; P < 0.05). All volumetric measurements had an excellent agreement with ICC > 0.9 except for ejection fraction (EF) (LVEF 0.81, RVEF 0.73). The image quality of deep learning cine images was decreased for end-diastolic and end-systolic contours, papillary muscles, and valve depiction (2.9 ± 0.5 vs. 3.5 ± 0.4; P < 0.05).

Conclusion
Deep learning cine volumetrics did not differ significantly from standard cine results except for LV mass, which was slightly overestimated with deep learning cine. Deep learning cine sequences result in a significant reduction in scan time with only slightly lower image quality.

Graphical Abstract
The formation of volatiles in fruit wine process and its impact on wine quality
Authors: Tan Jianxin , Ji Mingyue , Gong Jiangang , Chitrakar Bimal 
Published: July 2024

Abstract
Fruit wine is one of the oldest fermented beverages made from non-grape fruits. Owing to the differences in fruit varieties, growing regions, climates, and harvesting seasons, the nutritional compositions of fruits (sugars, organic acids, etc.) are different. Therefore, the fermentation process and microorganisms involved are varied for a particular fruit selected for wine production, resulting in differences in volatile compound formation, which ultimately determine the quality of fruit wine. This article reviews the effects of various factors involved in fruit wine making, especially the particular modifications differing from the grape winemaking process and the selected strains suitable for the specific fruit wine fermentation, on the formation of volatile compounds, flavor and aroma profiles, and quality characteristics of the wine thus produced.

Key points
• The volatile profile and fruit wine quality are affected by enological parameters.
• The composition and content of nutrients in fruit must impact volatile profiles.
• Yeast and LAB are the key determining factors of the volatile profiles of fruit wines.
Advances in biology, diagnosis and treatment of DLBCL
Authors: Shi Yuanfei , Xu Yi , Shen Huafei , Jin Jie , Tong Hongyan , Xie Wanzhuo 
Published: July 2024

AbstractDiffuse large B-cell lymphoma (DLBCL), with approximately 150,000 new cases worldwide each year, represent nearly 30% of all cases of non-Hodgkin lymphoma (NHL) and are phenotypically and genetically heterogeneous. A gene-expression profile (GEP) has identified at least three major subtypes of DLBCL, each of which has distinct clinical, biological, and genetic features: activated B-cell (ABC)-like DLBCL, germinal-center B-cell (GCB)-like DLBCL, and unclassified. Different origins are associated with different responses to chemotherapy and targeted agents. Despite DLBCL being a highly heterogeneous disease, more than 60% of patients with DLBCL can be cured after using rituximab combined with cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) to inhibit the growth of cancer cells while targeting the CD20 receptor. In recent decades, the improvement of diagnostic levels has led to a refinement classification of DLBCL and the development of new therapeutic approaches. The objective of this review was to summarize the latest studies examining genetic lesions and therapies for DLBCL.
Three years follow-up of Venetoclax in advanced-stage, relapsed or refractory AL amyloidosis with cardiac involvement and t(11;14) with BCL2 expression
Authors: Rieger Max J. , Pabst Thomas , Jeker Barbara , Paul Pamella , Bergamini Fabio , Bühler Marco M. , Condoluci Adalgisa , Flammer Andreas J. , Rossi Davide , Stussi Georg , Gerber Bernhard , Schwotzer Rahel 
Published: July 2024

AbstractFurther line treatment of patients with advanced stage AL amyloidosis with cardiac involvement is challenging. Venetoclax is a promising option, especially in t(11;14) and BCL2 expression.In our multicentre observational study, we report the 3-year follow-up of Venetoclax treatment in 9 patients with advanced, relapsed or refractory AL amyloidosis with t(11;14) and BCL-2 expression in > 50% of plasma cells. At baseline, all patients had been previously treated with daratumumab, all had cardiac involvement with revised Mayo stage III or IV/ European modification of Mayo 2004 IIIA or IIIB (1/9 unclassified due to missing troponin T), 5/9 patients had renal involvement.After a median of 35 months (range 25–49) since the start of Venetoclax, 8/9 patients were still alive (OS 89%). First and best hematological responses were observed after a median of 26 days (11–125) and 106 days (35–659), overall response rate was 100% (7/9 CR, 2/9 VGPR). Where observed, organ response was documented within the first 6 months of therapy, including cardiac (6/9) and renal (3/5) improvements. Venetoclax was discontinued in 6/9 patients after a median of 15 months (11–48) due to toxicity (2/9), disease progression (2/9), fixed treatment duration (1/9), or safety concerns (1/9).In conclusion, Venetoclax induces a rapid and deep hematologic response with consistent improvement in organ function with an acceptable safety profile in patients with pretreated, advanced stage AL amyloidosis with cardiac involvement and BCL2 expression with and potentially without detected t(11:14), which warrants further investigation.
Picker routing in scattered storage warehouses: an evaluation of solution methods based on TSP transformations
Authors: Wildt Constantin , Weidinger Felix , Boysen Nils 
Published: July 2024

AbstractTo optimize their order fulfillment processes, many e-commerce warehouses employ a storage assignment strategy known as scattered or mixed-shelves storage. Under this approach, unit loads of homogeneous products are divided, and individual pieces are stored in various shelves throughout the warehouse. This arrangement ensures that products that appear together on unpredictable pick lists are stored in close proximity somewhere in the huge warehouses, reducing the travel distance for pickers. Despite these advancements, efficiently guiding pickers through the warehouse remains a significant planning challenge. Since the same products can be found in multiple storage positions, the traditional picker routing problem becomes more complex, as an additional selection task arises regarding which shelf to retrieve each requested product from. While previous research has developed several tailor-made solution algorithms, we demonstrate that known transformation schemes used for different variants of the well-known Traveling Salesman Problem (TSP) can be utilized to convert the single picker routing problem with scattered storage (SPRP-SS) into a classical TSP. This approach enables us to leverage the extensive array of state-of-the-art TSP solvers. The purpose of this paper is to explore the performance of these solvers when applied to solving the SPRP-SS. Through our computational study, we found that existing TSP solvers exhibit good performance, allowing near-optimal solutions to be obtained in less than a second for real-world scale SPRP-SS instances. Moreover, the efficiency of these TSP solvers remains unaffected by the number of cross aisles in the warehouse. Consequently, we exploit this flexibility to investigate the impact of cross aisles on picking performance in scattered storage warehouses.
Temporal changes in CT-derived fractional flow reserve in patients after heart transplantation
Authors: Sharma Simran P. , Sanz Javier , Hirsch Alexander , Patel Richa , Constantinescu Alina A. , Barghash Maya , Mancini Donna M. , Brugts Jasper J. , Caliskan Kadir , Taverne Yannick J. H. J. , Manintveld Olivier C. , Budde Ricardo P. J. 
Published: July 2024

Abstract
Background
Adding functional information by CT-derived fractional flow reserve (FFRct) to coronary CT angiography (CCTA) and assessing its temporal change may provide insight into the natural history and physiopathology of cardiac allograft vasculopathy (CAV) in heart transplantation (HTx) patients. We assessed FFRct changes as well as CAV progression over a 2-year period in HTx patients undergoing serial CT imaging.

Methods
HTx patients from Erasmus MC and Mount Sinai Hospital, who had consecutive CCTAs 2 years apart were evaluated. FFRct analysis was performed for both scans. FFRct values at the most distal point in the left anterior descending (LAD), left circumflex (LCX), and right coronary artery (RCA) were measured after precisely matching the anatomical locations in both analyses. Also, the number of anatomical coronary stenoses of > 30% was scored.

Results
In total, 106 patients (median age 57 [interquartile range 47–67] years, 67% male) at 9 [6–13] years after HTx at the time of the baseline CCTA were included. Median distal FFRct values significantly decreased from baseline to follow-up for the LAD from 0.85 [0.79–0.90] to 0.84 [0.76–0.90] (p = 0.001), LCX from 0.92 [0.88–0.96] to 0.91 [0.85–0.95] (p = 0.009), and RCA from 0.92 [0.86–0.95] to 0.90 [0.86–0.94] (p = 0.004). The number of focal anatomical stenoses of > 30% increased from a median of 1 [0–2] at baseline to 2 [0–3] at follow-up (p = 0.009).

Conclusions
The distal coronary FFRct values in post-HTX patients in each of the three major coronary arteries decreased, and the number of focal coronary stenoses increased over a 2-year period. Temporal FFRct change rate may become an additional parameter in the follow-up of HTx patients, but more research is needed to elucidate its role.

Clinical relevance statement
CT-derived fractional flow reserve (FFRct) is important post-heart transplant because of additional information on coronary CT angiography for cardiac allograft vasculopathy (CAV) detection. The decrease and degree of reduction in distal FFRct value may indicate progression in anatomic CAV burden.

Key Points

CT-derived fractional flow reserve (FFRct) is important for monitoring cardiac allograft vasculopathy (CAV) in heart transplant patients.

Over time, transplant patients showed a decrease in distal FFRct and an increase in coronary stenoses.

Temporal changes in FFRct could be crucial for transplant follow-up, aiding in CAV detection.
Is choroid plexus growth altered in isolated ventriculomegaly on fetal neuro-ultrasound?
Authors: Hu Wei-Xi , Zhan Xin , Lu Dan , Li Zhi-Qiang 
Published: July 2024

Abstract
Objectives
Reveal developmental alterations in choroid plexus volume (CPV) among fetuses with isolated ventriculomegaly (VM) through neuro-ultrasound.

Methods
This prospective study aimed to assess the development of fetal CPV in normal fetuses and those with isolated VM through neuro-ultrasound. The fetuses of isolated VM were categorized into mild, moderate, and severe groups, and subsequently, the lateral ventricle evolution was monitored. The developmental alterations in CPV among fetuses with isolated VM were determined by comparing the CPV z-scores with those of normal fetuses. Receiver operating characteristics curve analysis was used to assess the predictive value of altered CPV in lateral ventricle evolution.

Results
A total of 218 normal fetuses and 114 isolated VM fetuses from 22 weeks to 35 weeks of gestation were included. The CPV decreased as the isolated VM was getting worse. Both fetuses with isolated moderate ventriculomegaly and those with isolated severe ventriculomegaly exhibited reduced CPV compared to normal fetuses. The CPV in fetuses with isolated mild ventriculomegaly (IMVM) varied, with some showing a larger CPV compared to normal fetuses, while others exhibited a smaller CPV. The larger CPV in cases of IMVM may serve as a predictive factor for either regression or stability of the lateral ventricle, while reduced CPV in cases of isolated VM may indicate worsening of the lateral ventricle.

Conclusion
The growth volume of fetal CP exhibited alterations in fetuses with isolated VM, and these changes were found to be correlated with the evolution of the lateral ventricle.

Clinical relevance statement
Neuro-ultrasound revealed varying degrees of alterations in the volume development of the choroid plexus within the fetus with isolated VM. The findings can help predict lateral ventricle prognosis, greatly contributing to prenatal diagnosis strategies for fetuses with isolated VM.

Key Points

The volume of choroid plexus growth is altered in fetuses with isolated VM.

The altered CPV in isolated VM was associated with lateral ventricle evolution.

The findings are useful for prenatal counseling and managing fetuses with isolated VM.
Cavitation in blunt impact traumatic brain injury
Authors: Finan John D. , Vogt Thea E. , Samei Yasaman 
Published: July 2024

AbstractTraumatic brain injury (TBI) poses a major public health challenge. No proven therapies for the condition exist so protective equipment that prevents or mitigates these injuries plays a critical role in minimizing the societal burden of this condition. Our ability to optimize protective equipment depends on our capacity to relate the mechanics of head impact events to morbidity and mortality. This capacity, in turn, depends on correctly identifying the mechanisms of injury. For several decades, a controversial theory of TBI biomechanics has attributed important classes of injury to cavitation inside the cranial vault during blunt impact. This theory explains counter-intuitive clinical observations, including the coup–contre-coup pattern of injury. However, it is also difficult to validate experimentally in living subjects. Also, blunt impact TBI is a broad term that covers a range of different head impact events, some of which may be better described by cavitation theory than others. This review surveys what has been learned about cavitation through mathematical modeling, physical modeling, and experimentation with living tissues and places it in context with competing theories of blunt injury biomechanics and recent research activity in the field in an attempt to understand what the theory has to offer the next generation of innovators in TBI biomechanics.
Metabolic rate and saliva cortisol concentrations in socially housed adolescent guinea pigs
Authors: Nemeth Matthias , Fritscher Susanna , Füreder Klara , Wallner Bernard , Millesi Eva 
Published: July 2024

AbstractAn individual’s energetic demands and hence metabolic rate can strongly change during adolescence, a phase characterized by profound morphological, physiological, and endocrine changes. Glucocorticoid hormones (e.g. cortisol) are released in response to hypothalamic–pituitary–adrenal–axis activity, modulate several metabolic processes, and can also be linked to increased metabolic rate. In domestic guinea pigs (Cavia aperea f. porcellus) housed in same-sex groups, cortisol concentrations increase during adolescence in males but remain stable in females, which was suggested to be related to different energetic demands by age. We therefore measured metabolic rate through oxygen (O2) consumption over 2.5 h in male and female guinea pigs housed in same-sex groups during adolescence at ages of 60, 120, and 180 days, which was paralleled by analyses of saliva cortisol concentrations before and after the measurement. The statistical analyses involved whole body metabolic rate (ml O2/h), body mass-corrected metabolic rate (ml O2/h/kg), and body mass-independent metabolic rate (ml O2/h statistically corrected for body mass). We found increasing cortisol concentrations with age in males only, but none of the three metabolic rate analyses revealed a sex difference by age. On the individual level, repeatability across ages was found in metabolic rate as well as in body mass and cortisol concentrations after the measurement, but not in “basal” cortisol concentrations. Our results suggest no sex-specific changes in metabolic rate and hence equal energetic demands in male and female guinea pigs during adolescence. Moreover, metabolic rate clearly represents a highly stable physiological trait already early in a guinea pig’s life irrespective of rather fluctuating cortisol concentrations.
Analysis of wound infections among pediatric patients following the 2023 Türkiye–Syria earthquakes
Authors: Yeşil Edanur , Tezol Özlem , Gokay Nahida , Sürmeli Döven Serra , Mısırlıoğlu Merve , Akça Mehtap , Özgökçe Özmen Berfin , Dikme Güldane , Durak Fatma , Alakaya Mehmet , Karahan Feryal , Kıllı İsa , Kuyucu Necdet 
Published: July 2024

Abstract
Purpose
On February 6, 2023, two earthquakes of magnitude 7.7 and 7.6 occurred consecutively in Turkey and Syria. This study aimed to investigate the predisposing factors for wound infection (WI) and the microbiological characteristics of wounds after earthquake-related injuries.

Methods
This descriptive study evaluated pediatric patients’ frequency of WI, and the clinical and laboratory parameters associated with the development of WI were investigated.

Results
The study included 180 patients (91 female). The mean age of the patients was 123.9 ± 64.9 months and 81.7% (n = 147) of them had been trapped under rubble. Antibiotic treatment to prevent WI had been administered to 58.8% (n = 106) of all patients. WI was observed in 12.2% (n = 22) of the cases. In patients who developed WI, the incidence of exposure to a collapse, crush syndrome, compartment syndrome, multiple extremity injury, fasciotomy, amputation, peripheral nerve injury, thoracic compression, blood product use, intubation, and the use of central venous catheters, urinary catheters, and thoracic tubes were more frequent (p < 0.05). The need for blood product transfusion was associated with the development of WI (OR = 9.878 [95% CI: 2.504–38.960], p = 0.001). The negative predictive values of not developing WI at values of white blood cell count of < 11,630/mm3, creatine kinase < 810 U/L, potassium < 4.1 mEq/L, ALT < 29 U/L, AST < 32 U/L, and CRP < 45.8 mg/L were 93.7%, 96.8%, 90.8%, 93.3%, 100%, and 93.5%, respectively. Gram-negative pathogens (81%) were detected most frequently in cases of WI. Seventy-five percent of patients were multidrug- and extensively drug-resistant.

Conclusion
This study leans empirical approach of our disaster circumstances. In cases with risk factors predisposing to the development of WI, it may be rational to start broad-spectrum antibiotics while considering the causative microorganisms and resistance profile to prevent morbidity.
Ultra-processed food consumption in UK adolescents: distribution, trends, and sociodemographic correlates using the National Diet and Nutrition Survey 2008/09 to 2018/19
Authors: Chavez-Ugalde Irazu Yanaina , de Vocht Frank , Jago Russell , Adams Jean , Ong Ken K. , Forouhi Nita G. , Colombet Zoé , Ricardo Luiza I. C. , van Sluijs Esther , Toumpakari Zoi 
Published: July 2024

Abstract
Purpose
We quantified levels of ultra-processed food (UPF) consumption and investigated consumption patterns in a representative sample of UK adolescents.

Methods
We used data from 4-day food diaries from adolescents in the UK National Diet and Nutrition Survey (NDNS) (2008/09–2018/19). UPF were identified using the NOVA classification. We estimated the percentage of Total Energy Intake (%TEI) and the absolute weight (grams). Linear regression models quantified differences in UPF consumption across survey years and its association with participant’s individual characteristics. This was an analysis of the repeated cross-sectional data from the UK NDNS Rolling Programme waves 1–11 (2008/09–2018/19). A total of 2991 adolescents (11–18y) with complete information on dietary intake were included.

Results
Mean UPF consumption was 861 (SD 442) g/d and this accounted for 65.9% (SD 13.4%) of TEI. Between 2008 and 2019, mean UPF consumption decreased from 996 to 776 g/d [ – 211 (95%CI  – 302;  – 120)] and from 67.7% to 62.8% of TEI [ – 4.8% (95%CI  – 8.1;  – 1.5)]. Higher %TEI was consumed by adolescents with lower socioeconomic status; white ethnicity and living in England North. A higher weight of UPF consumption (g/d) was associated with being male, white, age 18y, having parents with routine or manual occupation, living in England North, and living with obesity.

Conclusion
Average energy intake from UPF has decreased over a decade in UK adolescents. We observed a social and regional patterning of UPF consumption, with higher consumption among adolescents from lower socioeconomic backgrounds, from a white ethnicity and living in England North. Our findings suggest inequalities associated with UPF intake and factors that might lie beyond individual choice.
Lung Volumes in a Mouse Model of Pulmonary Allergic Inflammation
Authors: Rojas-Ruiz Andrés , Boucher Magali , Henry Cyndi , Packwood Rosalie , Soliz Jorge , Bossé Ynuk 
Published: July 2024

Abstract
Purpose
Air trapping, often attested in humans by elevated residual volume (RV) and ratio of RV on total lung capacity (RV/TLC), is frequently observed in asthma. Confirming these alterations in experimental asthma would be important for translational purposes. Herein, lung volumes were investigated in a mouse model of pulmonary allergic inflammation.

Methods
Eight- to 10-week-old male C57BL/6 and BALB/c mice were exposed once daily to intranasal house dust mite (HDM) for 10 consecutive days. All readouts were measured 24 h after the last exposure. Lung volumes were assessed with the flexiVent using a new automated method consisting of degassing the lungs followed by a full-range pressure–volume maneuver. The weight and the volume of the lungs were also measured ex vivo and a lobe was further processed for histological analyses.

Results
HDM exposure led to tissue infiltration with inflammatory cells, goblet cell hyperplasia, thickening of the airway epithelium, and elevated ex vivo lung weight and volume. It also decreased TLC and vital capacity but without affecting RV and RV/TLC. These observations were similar between the two mouse strains.

Conclusion
Alterations of lung volumes in a murine model of pulmonary allergic inflammation are inconsistent with observations made in human asthma. These discrepancies reflect the different means whereby lung volumes are measured between species. The invasive method used herein enables RV to be measured more precisely and without the confounding effect of air trapping, suggesting that changes in RV and RV/TLC using this method in mice should be interpreted differently than in humans.