bluuebunny/crossref_metadata_2025_split huggingface dataset:
Area under the inspiratory flow-volume curve (AIN): Proposed normative values
Authors: Ioachimescu Octavian C. , Stoller James K. 
Published: August 2024

Rationale
Area under expiratory flow-volume curve (AEX) has been shown to be a valuable functional measurement in respiratory physiology. Area under inspiratory flow-volume loop (AIN) also shows promise in characterizing upper and/or lower airflow obstruction.

Objectives
we aimed here to develop normative reference values for AIN, able to ascertain deviations from normal.

Methods
We analyzed AIN in 4,980 spirometry tests recorded in non-smoking, healthy individuals in the Pulmonary Function Testing Laboratory.

Results
The mean (95% confidence interval, CI), standard deviation and median (25th-75th interquartile range) AIN were 16.05 (15.79–16.31), 9.08 and 14.72 (9.12–21.42) L2·sec-1, respectively. The mean (95% CI) and standard deviation of the best-trial measurements for square root of AIN (Sqrt AIN) were 3.84 (3.81–3.87) and 1.14; 4.15 (4.12–4.18) and 1.03 in men, and 2.68 (2.63–2.72) and 0.72 L·sec-1/2 in women. The mean (standard deviation) of pre- and post-bronchodilator Sqrt AIN were 3.71 (1.17) and 3.81 (1.19) L·sec-1/2, respectively.
The mean (95% CI), standard deviation and lowest 5th percentile (lower limit of normal, LLN) of Sqrt AIN/Sqrt AEX (%) were 101.3 (100.82–101.88), 18.7, and 71.8%; stratified by gender, it was 102.2 (101.6–102.8), 18.6, and 72.8% in men, and 98 (96.9–99.2), 18.8, and 68.6% in women, respectively.

Conclusions
The availability of area under the inspiratory flow-volume curve (AIN) and the derived indices offers a promising opportunity to assess upper airway disease (e.g., involvement of larynx, trachea or major bronchi), especially because some of these measurements appear to be independent of age, race, height, and weight.
AmiR-P3: An AI-based microRNA prediction pipeline in plants
Authors: Ataei Sobhan , Ahmadi Jafar , Marashi Sayed-Amir , Abolhasani Ilia 
Published: August 2024

Background
MicroRNAs (miRNAs) are small noncoding RNAs that play important post-transcriptional regulatory roles in animals and plants. Despite the importance of plant miRNAs, the inherent complexity of miRNA biogenesis in plants hampers the application of standard miRNA prediction tools, which are often optimized for animal sequences. Therefore, computational approaches to predict putative miRNAs (merely) from genomic sequences, regardless of their expression levels or tissue specificity, are of great interest.

Results
Here, we present AmiR-P3, a novel ab initio plant miRNA prediction pipeline that leverages the strengths of various utilities for its key computational steps. Users can readily adjust the prediction criteria based on the state-of-the-art biological knowledge of plant miRNA properties. The pipeline starts with finding the potential homologs of the known plant miRNAs in the input sequence(s) and ensures that they do not overlap with protein-coding regions. Then, by computing the secondary structure of the presumed RNA sequence based on the minimum free energy, a deep learning classification model is employed to predict potential pre-miRNA structures. Finally, a set of criteria is used to select the most likely miRNAs from the set of predicted miRNAs. We show that our method yields acceptable predictions in a variety of plant species.

Conclusion
AmiR-P3 does not (necessarily) require sequencing reads and/or assembled reference genomes, enabling it to identify conserved and novel putative miRNAs from any genomic or transcriptomic sequence. Therefore, AmiR-P3 is suitable for miRNA prediction even in less-studied plants, as it does not require any prior knowledge of the miRNA repertoire of the organism. AmiR-P3 is provided as a docker container, which is a portable and self-contained software package that can be readily installed and run on any platform and is freely available for non-commercial use from: https://hub.docker.com/r/micrornaproject/amir-p3
A single-center retrospective study on the clinical features of thyrotoxic periodic paralysis
Authors: Yamada Kota , Tanabe Akiyo , Hashimoto Makiko , Ohsugi Mitsuru , Ueki Kohjiro , Kajio Hiroshi 
Published: August 2024

Purpose
Thyrotoxic periodic paralysis (TPP) is characterized by muscle paralysis and significant intracellular potassium movement resulting in hypokalemia. Since TPP is a rare condition, only a few studies have explicated the clinical characteristics of patients with this disease. This study aimed to elucidate the clinical characteristics of patients with TPP by comparing them with those with thyrotoxicosis without paralysis (non-TPP) and sporadic periodic paralysis (SPP).

Methods
This was a single-center retrospective cohort study. Clinical data of patients with hyperthyroidism (n = 62) or periodic paralysis (n = 92) who were emergently admitted to our hospital was extracted from the electronic medical records and analyzed.

Results
All patients in the TPP group (15 males and 2 females) had Graves’ disease, with 14 being newly diagnosed. The average serum potassium level on admission was 2.3±0.75 mEq/L. No significant correlation was observed among serum potassium level, amount of potassium required for normalization, and thyroid hormone levels. The TPP group showed significantly younger age, higher male ratio and body mass index (BMI), and lower serum potassium and phosphorus levels than the non-TPP group, which comprised 36 patients with Graves’ disease. No significant differences were observed between the TPP and SPP (n = 11) groups in terms of age, sex, BMI, serum electrolyte levels, potassium requirement for normalization, and recovery time.

Main conclusions
Considering that most patients with TPP have undiagnosed Graves’ disease, distinguishing TPP from SPP based on clinical information and course alone is difficult in emergency settings. Therefore, for early detection and launch of specific treatment of Graves’ disease, screening for thyroid hormone and anti-thyroid stimulating hormone receptor antibody levels is necessary when treating patients with periodic paralysis.
Effects of moderate doses of ionizing radiation on experimental abdominal aortic aneurysm
Authors: Riazi Goran , Brizais Chloe , Garali Imene , Al-rifai Rida , Quelquejay Helene , Monceau Virginie , Vares Guillaume , Ould-Boukhitine Lea , Aubeleau Damien , Gilain Florian , Gloaguen Celine , Dos Santos Morgane , Ait-Oufella Hafid , Ebrahimian Teni 
Published: August 2024

BackgroundExposure to ionizing radiation has been linked to cardiovascular diseases. However, the impact of moderate doses of radiation on abdominal aortic aneurysm (AAA) remains unknown.MethodsAngiotensin II-infusedApoe-/-mice were irradiated (acute, 1 Gray) either 3 days before (Day-3) or 1 day after (Day+1) pomp implantation. Isolated primary aortic vascular smooth muscle cells (VSMCs) were irradiated (acute 1 Gray) for mechanistic studies and functional testing in vitro.ResultsDay-3 and Day+1 irradiation resulted in a significant reduction in aorta dilation (Control: 1.39+/-0.12; Day-3: 1.12+/-0.11; Day+1: 1.15+/-0.08 mm, P<0.001) and AAA incidence (Control: 81.0%; Day-3: 33.3%, Day+1: 53.3%) compared to the non-irradiated group. Day-3 and Day+1 irradiation led to an increase in collagen content in the adventitia (Thickness control: 23.64+/-2.9; Day-3: 54.39+/-15.5; Day+1 37.55+/-10.8 mm, P = 0.006). However, the underlying protective mechanisms were different between Day-3 and Day+1 groups. Irradiation before Angiotensin II (AngII) infusion mainly modulated vascular smooth muscle cell (VSMC) phenotype with a decrease in contractile profile and enhanced proliferative and migratory activity. Irradiation after AngII infusion led to an increase in macrophage content with a local anti-inflammatory phenotype characterized by the upregulation of M2-like gene and IL-10 expression.ConclusionModerate doses of ionizing radiation mitigate AAA either through VSCM phenotype or inflammation modulation, depending on the time of irradiation.
Patient satisfaction with the management of refractory and unexplained chronic cough in Canada: Results from a national survey
Authors: Khan Sana , Brister Danica , Abraham Ted , Laventure Samuel , Sahakian Sevag , Juliá Berta , Satia Imran 
Published: August 2024

Background
Chronic cough (persisting for ≥8 weeks) is a common disorder affecting approximately 5 to 10% of adults worldwide that is sometimes refractory to treatment (refractory chronic cough [RCC]) or has no identifiable cause (unexplained chronic cough [UCC]). There is minimal information on the patient’s experience of RCC/UCC in Canada. The aim of this study was to evaluate the patient journey and perceptions related to RCC/UCC management in Canada.

Methods
Our exploratory study included Canadians in the Leger Opinion Panel and focused on individuals with RCC or UCC. Key entry criteria were: age ≥18 years, cough on most days for ≥8 weeks, no smoking within 1 year, no serious respiratory disease or lung cancer, and not taking angiotensin-converting enzyme inhibitors. Individuals who met entry criteria were invited to complete an approximately 30-minute online survey with questions on demographic characteristics, healthcare professional (HCP) interactions, diagnosis of underlying conditions, current treatments, and satisfaction with HCPs and chronic cough therapies.

Results
A total of 49,076 individuals completed the chronic cough screening questionnaire (July 30, 2021 to September 1, 2021): 1,620 (3.3%) met entry criteria for RCC or UCC, and 1,046 (2.1%) completed the online survey (mean age of 45 years, 61% female). Most respondents (58%) reported their chronic cough was managed by a general practitioner (GP). Forty-four percent of respondents did not have a diagnosis of an underlying condition for their cough. Breathing tests (39%) and chest imaging (34%) were the most common diagnostic tests. Cough suppressants (18%) were the most frequent current treatment. Respondents were moderately satisfied with their HCPs, but more than half considered their treatment ineffective and 34% had considered no longer seeking medical attention because of a lack of treatment success.

Conclusions
Individuals with RCC/UCC in Canada are largely unsatisfied with the effectiveness of treatment. Additional HCP education and new treatment options are needed to improve patient satisfaction.
Satyajit Ray: The Man Who Knew Too Much, Barun Chanda (2022)
Authors: Pal Shyam Sundar , Ghoshal Ananya 
Published: August 2024

Review of: Satyajit Ray: The Man Who Knew Too Much, Barun Chanda (2022)
New Delhi: Om Books International, 347 pp.,
ISBN 978-9-39283-465-3, p/bk, $11.99
Exposición temporal: Virreinato entre mares
Authors: Martínez Muñoz María Fernanda , Estrada López Fernando Fady 
Published: August 2024

Exposición temporal: Virreinato entre mares Museo de El Carmen Sala de Arcos, planta baja Av. Revolución 4 y 6 San Ángel, alcaldía Álvaro Obregón, 01000 Ciudad de México Del 18 de junio al 22 de septiembre de 2024
La responsabilidad de los administradores de personas jurídicas privadas por daño ambiental
Authors: Rostán Matías Ignacio 
Published: August 2024

La crisis ecológica, producto del cambio climático, el calentamiento global, la pérdida de la biodiversidad y la contaminación del ambiente es una problemática que le es propia a la sociedad actual. En este contexto, el cumplimiento de la normativa ambiental por parte de los administradores de personas jurídicas (tengan éstas finalidad económica o no) es sustancial en pos de prevenir daños ambientales.
En Argentina, el Código Civil y Comercial (CCC) y los microsistemas jurídicos especiales contienen disposiciones sobre la responsabilidad de los administradores de personas jurídicas privadas. Por otra parte, la normativa ambiental tutela el daño ambiental, y establece consecuencias legales para los administradores que generen daños al ambiente en el desarrollo de sus facultades.
El presente artículo se propone identificar y analizar la normativa que regula a la responsabilidad de los administradores de personas jurídicas privadas y aquella que tutela el daño ambiental en el ámbito del ordenamiento jurídico argentino, con el objeto de labrar algunas reflexiones en torno a la importancia de que los administradores integren el deber de preservar el ambiente sano, equilibrado, apto para el desarrollo humano y para que las actividades productivas satisfagan las necesidades presentes sin comprometer las de las generaciones futuras
De la súplica al emprendedurismo
Authors: Romero Santiago Manuel , Villarreal Agustín 
Published: August 2024

A partir de dos investigaciones etnográficas realizadas en puntos diversos del universo penitenciario cordobés, nos enfocaremos en la gestión estatal de las muertes que ocurren en las prisiones de Córdoba y los saberes-haceres que se articulan en su reclamo y tramitación. Asimismo, observaremos cómo esos aprendizajes y las consecuencias del encierro son, ya en libertad, moduladas por otras agencias que promueven otros lenguajes y formas de hablarle al Estado.
Se trata de una pesquisa que se enfocó en analizar las actuaciones tutelares del Patronato del Liberado de Córdoba; donde se acompañaron capacitaciones para la obtención de microcréditos. La otra investigación, se enfocó en muertes producidas en prisiones cordobesas, atendiendo a los entramados institucionales atravesados por diferentes agentes para tramitarlas y las estrategias desarrolladas. A partir del diálogo entre esas investigaciones, en este artículo centraremos en cómo era modulado el lenguaje del reclamo y la súplica por las personas que transitan/ron las cárceles en los distintos tramos de sus experiencias penitenciarias, por parte de sus familiares y de los letrados que acompañaban sus causas. También consideraremos cómo ese lenguaje era modulado, o pretendía serlo, por las administradoras del Patronato y otros agentes del estado cordobés en capacitaciones orientadas a liberados y liberadas.
Die Entscheidbarkeit des persönlichen Ehrstatus frühneuzeitlicher Männer und Frauen. Konfliktsfälle im Vergleich
Authors: Zeilinger Florian 
Published: August 2024

Zusammenfassung
Die diversen frühneuzeitlichen Fälle gewaltsamer (Raufhändel) und gerichtlicher Ehrverteidigung (Injurienprozesse) sowie der Ehrlichsprechung berufsbedingt unehrlicher oder devianzbedingt ehrloser Personen lassen sich mithilfe entscheidungstheoretischer Analysekategorien vergleichen und damit zusammenführen. Trotz geschlechterspezifisch unterschiedlicher Ehrkonzepte konnten sowohl straffällig gewordene Männer als auch entjungferte Frauen um Ehrrestitution bitten. Beleuchtet werden die Entscheidbarkeit des persönlichen Ehrstatus in verschiedenen Phasen eines Konflikts, seine Entscheidbarmachung, die Entscheidungsressourcen, die Entscheidungsmodi sowie die Entscheidungszeit. So zeigt sich, dass die entsprechende Benennungsmacht der den Ehrstatus Beurteilenden und konkurrierende Normen, die eine Kritik an der vorangegangenen Ehrzuschreibung erlaubten, zu den Entscheidungsressourcen zählten. Entscheidungsmodi konnten obrigkeitlich durchgeführte Verfahren, aber auch Einzelentscheidungen der Mituntertanen sein, die dabei keineswegs entscheidungsfaul erscheinen. Der persönliche Ehrstatus galt in all den Fällen als entscheidbar, in denen es um die auf das individuelle Verhalten bezogene Ehre ging, in der er also über die entsprechende Zeitdimension verfügte. Unter diesen Umständen konnte er durch liminalisierende Temporalisation, Gabentauschpraktiken und das Erzählen von Geschichten erneut entscheidbar gemacht werden.
„Trauer um die Juden“ Chinesische Intellektuelle und der Diskurs über den nationalsozialistischen Antisemitismus (1933–1949)
Authors: Zhang Ruoyu 
Published: August 2024

Zusammenfassung
Auf der Grundlage der Volltextdatenbank für Zeitschriften der Republikzeit (1911–1949) konzentriert sich der Artikel vor allem auf die Diskursgeschichte chinesischer Intellektueller zum NS-Antisemitismus im Kontext der dynamischen Beziehungen zwischen China, Deutschland und Japan in den 1930er und 1940er Jahren. Hier sind drei Thesen zu verfolgen: 1.) Angesichts der europaweiten nationalsozialistischen Judenverfolgung nahm die Mehrheit der Chinesen einen humanitären Standpunkt ein und empfand Sympathie für die Juden, wenngleich einige Individuen – zur Unterstützung der japanischen und reichsdeutschen Kriegs- und Judenpolitik – versuchten, die antisemitischen Verschwörungstheorien in der japanischen Besatzungszone zu verbreiten. 2.) Die chinesische Auseinandersetzung mit der Judenfrage war vorwiegend in den Jahren 1938 und 1939 in der Shanghaier Presse präsent, als mitteleuropäische Juden in dieser fernöstlichen Metropole ihre Zuflucht fanden. Ihr Schicksal wurde vor allem unter sozialgeschichtlichen Gesichtspunkten intensiv analysiert, wobei sich bei der Mehrheit der Intellektuellen ein allgemeiner Konsens über zwei Hauptmotive des nationalsozialistischen Antisemitismus herausbildete: die jüdische Diaspora und den Neid auf den angeblich unermesslichen jüdischen Reichtum. 3.) In der chinesisch-japanischen Kriegssituation sahen die meisten Chinesen die mittellosen jüdischen Flüchtlinge ebenso als Opfer der politischen und sozialen Umstände wie sich selbst, weshalb die Intellektuellen dem jüdischen Widerstand wie zum Beispiel dem Zionismus volles Vertrauen entgegenbrachten und ein jüdisches Überleben erwarteten. Die Überlebenshoffnung der Chinesen bezog sich unverkennbar eher auf das eigene Land und Volk, das im antifaschistischen Weltkrieg ebenfalls schwer gelitten habe.
Discovering optical solutions to a nonlinear Schrödinger equation and its bifurcation and chaos analysis
Authors: Alsallami Shami A. M. 
Published: August 2024

Abstract
The pursuit of solitary wave solutions to complex nonlinear partial differential equations is gaining significance across various disciplines of nonlinear science. This study seeks to uncover the solutions to the perturbed nonlinear Schrödinger equation using a robust and efficient analytical method, namely, the generalized exponential rational function technique. This equation is a fundamental tool used in various fields, including fluid mechanics, nonlinear optics, plasma physics, and optical communication systems, and has numerous practical applications across multiple disciplines. The employed method in this study stands out from existing approaches by being more comprehensive and straightforward. It offers a broader range of symbolic structures, surpassing the capabilities of some previously known methods. By applying this method to the perturbed nonlinear Schrödinger equation, we obtain a variety of exact solutions that significantly expand the existing literature and provide a fresh understanding of the model’s properties. Through numerical simulations, we demonstrate the dynamic characteristics of the system, including bifurcation and chaos analysis, and validate our findings by adjusting parameter settings to match expected behaviors.
Corn silk: A promising source of antimicrobial compounds for health and wellness
Authors: Marok Tanya , Rasane Prasad , Kaur Sawinder , Amanjyoti  , Ercisli Sezai , Assouguem Amine , Choudhary Ravish , Ullah Riaz , Alqahtani Ali S. , Singh Jyoti 
Published: August 2024

Abstract
Microbial diseases remain a leading cause of death worldwide, and the emergence of new infections underscores the need for innovative treatments. Plant-based sources for antimicrobial drugs are gaining popularity due to their fewer side effects compared to synthetic drugs. Corn silk (CS), an ancient medicinal plant, has been used for thousands of years to treat ailments such as edema and cystitis. It is a rich source of vitamins and minerals and acts as an anti-hypertensive, anti-diabetic, anti-cancerous, antioxidant, and antimicrobial agent. Its bioactive components, which include phenolic acids, flavonoids, tannins, alkaloids, terpenes, and saponins, are responsible for these therapeutic benefits. Numerous studies have examined the antibacterial effectiveness of diverse CS extracts, unveiling several methods by which CS demonstrates its antimicrobial properties. These mechanisms include the inhibition of energy production within microbial cells, interference with DNA and protein synthesis, prevention of biofilm formation, disruption of cell wall synthesis, and direct disruption of the cell wall structure. CS effectively blocks microbial growth and multiplication by focusing on these vital processes. Therefore, the purpose of this review is to provide a comprehensive summary of the different bioactive compounds found in CS, as well as their mechanisms of action against microbes. Understanding these mechanisms highlights CS’s potential as a potent source for developing new antimicrobial medications and supplements, offering a natural and effective alternative in the fight against infectious diseases.
Digital Transformation of Archives in the Context of the Introduction of an Electronic Document Management System in Kazakhstan
Authors: Nurbatyrova Raushan , Japarov Boris , Apakhayev Nurlan , Abdulaziz Biyakhmet , Khushkeldiyeva Sandugash 
Published: August 2024

Abstract
The relevance of this study is conditioned by the significant importance of the organisation of electronic document management in the Republic of Kazakhstan and the broad prospects that open up during the digitalisation of state archives. The purpose of the study is to investigate the key aspects of the digitalisation of archives in Kazakhstan at the current stage of the country’s economic development. The basis of its methodological approach was a theoretical investigation of the processes of digitalisation of archival information under the conditions of practical application of the electronic document management system in the Republic of Kazakhstan, with the results obtained indicating the major significance of the digital transformation of archives in the context of the programmes Resolution of the Government of the Republic of Kazakhstan No. 827 “About Approval of the State Program “Digital Kazakhstan” (2017) and “Information Kazakhstan-2020”: State Program (2021) adopted at the state level. The sequential transfer of archival information to digital media for storage offers numerous advantages over traditional paper media, with the state level in Kazakhstan regulating the digital transformation of archives and the adoption and use of a unified electronic document management system by enacting a number of laws that regulate a wide range of related issues. The introduction of an electronic document management system has also established numerous advantages, largely determining the significant prospects for the development of this system of interaction between organisations (state, public, legal entities, and individuals). The practical significance of the results obtained lies in the possibility of their application in the organisation of the activities of enterprises and organisations of the Republic of Kazakhstan that implement measures to digitalise archival data within the unified electronic document management system.