bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tailoring the Lattice Thermal Conductivity of Al‐Incorporated Ag2Se for Near Room Temperature Waste Heat Recovery
Authors: Mathew Tony , Vijay V. , Archana J. , Navaneethan M. , Ponnusamy S. 
Published: July 2024

AbstractAg2Se is categorized as a typical ′phonon‐liquid‐electron‐crystal (PLEC)′material, exhibiting an extremely low
. In this study, Al substituted Ag2Se samples were synthesized by mechanical alloying process followed by hot press densification technique. The Al substituted sample shows an exceptionally high mobility of 2360 cm2 V−1 S−1 at room temperature and a maximum power factor of 1442 μWm−1 K−2 at 383 K. The phonon scattering induced by various crystal imperfections due to Al substitution helped to obtain a very low lattice thermal conductivity
value of 0.3 W/mK. A high figure of merit (zT) of 0.4 at 383 K was obtained as a result of the simultaneous effect of boosting the electrical transport properties and decreasing the thermal conductivity. This present work summarizes that the Al substitution is highly significant in improving the thermoelectric properties of Ag2Se.
Effect of Erdafitinib on the Pharmacokinetics of Midazolam and Metformin in Patients With Advanced Solid Tumors Harboring FGFR Gene Alterations
Authors: Zhu Wei , Baig Mahadi , Naini Vahid , De Meulder Marc , Akapame Sydney , De Zwart Loeckie , Haddish‐Berhane Nahor , Triantos Spyros 
Published: July 2024

AbstractErdafitinib, an oral pan‐FGFR inhibitor, is used in locally advanced or metastatic urothelial carcinoma for adults with FGFR3 genetic alterations and whose disease progressed following prior systemic therapy. This drug‐drug interaction substudy evaluated the effect of erdafitinib on the pharmacokinetics of midazolam (cytochrome P450 3A4 substrate), and metformin (organic cation transporter 2 substrate). Twenty‐five patients with advanced solid tumors harboring FGFR gene alterations received pretreatment with single doses of midazolam and metformin, followed by a daily dose of erdafitinib. Drug‐drug interaction assessments were performed at erdafitinib steady state following coadministration of single doses of midazolam and metformin, respectively. Geometric mean ratios for maximum plasma concentration and area under the plasma concentration‐time curve (AUC) from time 0 to the last measurable concentration, and AUC from time 0 to infinity were estimated using linear mixed‐effects models (90% confidence interval within 80%‐125% indicated no interaction). The 90% confidence intervals of geometric mean ratios for maximum plasma concentration, AUC from time 0 to the last measurable concentration, and AUC from time 0 to infinity of midazolam (86.3%, 88.5%, and 82.1%), 1‐OH midazolam (99.8%, 97.4%, and 101.5%), and metformin (108.7%, 119.0%, and 113.9%) were either contained or slightly outside the 80%‐125% interval and not considered clinically meaningful. Adverse events were consistent with the known erdafitinib safety profile; no new safety signals emerged. Thus, repeated dosing of erdafitinib had no clinically meaningful effect on the pharmacokinetics of midazolam or metformin.
DC‐link voltage stability analysis for three‐level boost + full‐bridge LLC cascaded converter using impedance modeling
Authors: Ma Ruiqi , He Shuiyuan , Xie Chongshan , Liu Xinbo , Zhang Jiepin , Ma Yingtao , Kang Chengwei , Diao Lijun 
Published: July 2024

AbstractThe cascade converter system has been widely concerned along with the medium power operating conditions, and it is crucial to address the intricate interplay among individual modules to ensure stability of both the source and load subsystems. This paper analyzes the DC‐link voltage stability based on impedance matching and proposes a normalized sensitivity calculation method based on the control strategy, which prevents the complex products and matrix calculations of traditional methods. The three‐level boost (TLB) output impedance model is derived based on state‐space averaging for open‐loop and considering the double‐loop, and the full‐bridge LLC (FBLLC) input impedance model is derived based on the fundamental equivalent circuit. Then the effect of the double‐loop PI parameters on the output impedance of the TLB is analyzed in detail based on the normalized sensitivity and verified by the Bode plots. The experimental results of the 30 kW prototype indicate that the control parameters were varied by a factor of 10 compared to the theoretical control group. The most significant alteration was the modification of the kp_i, resulting in an 8.9% increase in the DC‐link voltage ripple, while the ki_v was modified, resulting in a 0.53% increase, indicating that the effects of the PI parameter are consistent with the normalized sensitivity results.
Soil flooding filters evolutionary lineages of tree communities in Amazonian riparian forests
Authors: de Souza Sthefanie do Nascimento Gomes , Batista Darlisson Mesquita , Quaresma Adriano Costa , Costa Ana Luiza , Demarchi Layon Oreste , Albuquerque Bianca Weiss , Klein Viviane Pagnussat , Feitoza Gildo , de Resende Angélica Faria , Mori Gisele Biem , Wittmann Florian , Oliveira Leidiane Leão , Mortati Amanda Frederico , da Cunha Alan Cavalcanti , Schongart Jochen , Lopes Aline , Piedade Maria Teresa Fernandez , André Thiago 
Published: July 2024

AbstractInundations in Amazonian black‐water river floodplain result in the selection of different tree lineages, thus promoting coexistence between species. We investigated whether Amazonian tree communities are phylogenetically structured and distributed along a flooding gradient from irregularly flooded forests along streams embedded within upland (terra‐firme) forest to seasonally flooded floodplains of large rivers (igapós). Floristic inventories and hydrological monitoring were performed along the Falsino River, a black‐water river in the eastern Amazon within the Amapá National Forest. We constructed a presence‐and‐absence matrix and generated a phylogeny using the vascular plant database available in GenBank. We calculated the standardized values of the metrics of phylogenetic diversity (ses.PD), average phylogenetic distance (ses.MPD), and average nearest‐neighbor distance (ses.MNTD) to test whether the history of relationships between species in the community is influenced by inundation. We used the phylogenetic endemism (PE) metric to verify the existence of taxa with restricted distribution. Linear regressions were used to test whether phylogenetic metrics have a significant relationship with the variables: maximum flood height, maximum water table depth, and maximum flood amplitude. The results show that forests subject to prolonged seasonal flooding have reduced taxon richness, low phylogenetic diversity, and random distribution of lineages within communities. On the other hand, terra‐firme riparian forests showed higher rates of taxon richness, diversity, and phylogenetic dispersion, in addition to greater phylogenetic endemism. These results indicate that seasonal and predictable soil flooding filters tree lineages along the hydrographic gradient. Different adaptations to root waterlogging are likely requirements for colonization in these environments and may represent an important factor in the diversification of tree lineages in the Amazon biome.
Adapting to changing methodology in a long‐term experiment
Authors: McNamara Manning Katherine , Perrone Julia , Petrycki Stephanie , Landis Douglas A. , Bahlai Christie A. 
Published: July 2024

AbstractLong‐term experiments are critical for understanding ecological processes, but their management comes with unique challenges. As time passes, projects may encounter unavoidable changes due to external factors, like availability of materials, affecting aspects of their research methodology. At the Kellogg Biological Station Long‐Term Ecological Research Site, one of the many National Science Foundation‐funded long‐term research stations, a three‐decade project recently experienced a supply‐chain‐induced change in insect sampling methodology in their lady beetle observation study. Since 1989, lady beetles (Coleoptera: Coccinellidae) have been sampled weekly over the growing season using yellow sticky cards. In 2021, the original sticky traps were discontinued by the manufacturer and replaced with a similar, but not identical trap. We conducted a 3‐year study while the new traps were phased in to examine how the trap change would impact the observed biodiversity patterns at the site. We examined community metrics and individual taxa captures to examine within‐year and between‐year differences in performance between the card types. Overall, we noted several small but statistically detectable differences in capture patterns between the two trap types. After accounting for other sources of variation, we observed a difference in Shannon diversity of insects captured on the two card types, but not richness or abundance, for the overall insect community. Yet, these differences were dwarfed by the magnitude of difference observed between years within card types. For individual taxa, similar patterns held: between trap differences could be detected statistically, but the number of differences in capture rate between trap types was less than the number of differences observed for the same trap, between years. Thus, we conclude that while subtle changes in methodology could impact data produced in long‐term experiments; in this case, the magnitude of this change is smaller than other factors such as time and plant treatment. However, if sustained changes in the capture rates of focal taxa are observed, future data users may use our observations to specifically quantify and correct for these shifting patterns related to the protocol change.
Increased intake of tree forage by moose is associated with intake of crops rich in nonstructural carbohydrates
Authors: Felton Annika M. , Spitzer Robert , Raubenheimer David , Hedwall Per‐Ola , Felton Adam , Nichols Ruth V. , O'Connell Brendan L. , Malmsten Jonas , Löfmarck Erik , Wam Hilde K. 
Published: July 2024

AbstractAnimals representing a wide range of taxonomic groups are known to select specific food combinations to achieve a nutritionally balanced diet. The nutrient balancing hypothesis suggests that, when given the opportunity, animals select foods to achieve a particular target nutrient balance, and that balancing occurs between meals and between days. For wild ruminants who inhabit landscapes dominated by human land use, nutritionally imbalanced diets can result from ingesting agricultural crops rich in starch and sugar (nonstructural carbohydrates [NCs]), which can be provided to them by people as supplementary feeds. Here, we test the nutrient balancing hypothesis by assessing potential effects that the ingestion of such crops by Alces alces (moose) may have on forage intake. We predicted that moose compensate for an imbalanced intake of excess NC by selecting tree forage with macro‐nutritional content better suited for their rumen microbiome during wintertime. We applied DNA metabarcoding to identify plants in fecal and rumen content from the same moose during winter in Sweden. We found that the concentration of NC‐rich crops in feces predicted the presence of Picea abies (Norway spruce) in rumen samples. The finding is consistent with the prediction that moose use tree forage as a nutritionally complementary resource to balance their intake of NC‐rich foods, and that they ingested P. abies in particular (normally a forage rarely eaten by moose) because it was the most readily available tree. Our finding sheds new light on the foraging behavior of a model species in herbivore ecology, and on how habitat alterations by humans may change the behavior of wildlife.
Investigation of the water environmental DNA/RNA profile for non‐invasive biomonitoring of the fish pathogen Aeromonas salmonicida subsp. salmonicida and detection of immune responses in rainbow trout (Oncorhynchus mykiss)
Authors: Marana Moonika Haahr , Jensen Hannah Malene , Christiansen Debes Hammershaimb , Petersen Petra Elisabeth , Dahl Maria Marjunardóttir , Duan Yajiao , Henard Cyril , Jørgensen Louise von Gersdorff 
Published: July 2024

AbstractAquaculture industries face challenges in fish production, primarily due to disease occurrence. Clinical manifestations of these diseases often indicate a considerable advancement in the pathological process. Infected fish often experience morbidity, leading to compromised welfare and substantial economic losses for production facilities. Therefore, prophylaxis and early detection of the pathogens could allow the facility managers to intervene or treat the disease before clinical disease signs occur. For the first time, environmental DNA/RNA (collectively eNA) was used to detect the salmonid pathogen Aeromonas salmonicida subsp. salmonicida in the water hosting rainbow trout (Oncorhynchus mykiss). This took place under controlled experimental conditions, before the occurrence of clinical outcome and mortality. The concentration of bacteria in the water was determined by using a standard curve. To determine the window of possible intervention, bacterial concentration was measured from an early stage of disease and throughout when fish became moribund. Furthermore, the acute phase protein, serum amyloid A produced by rainbow trout, was detected in the water and was found to be up‐regulated 4 days post challenge. It was thereby shown that it is possible to detect strong immune responses in the fish in a non‐invasive manner. The detection of eNA from the water can be used as a tool to detect pathogens in the early phase of infection before the disease becomes severe. This will facilitate interventions to limit the disease and increase the welfare of the fish, which is becoming a requirement for a more sustainable and ethical animal production.
Room Temperature Ni‐Catalyzed Ullmann Reaction of (Hetero)aryl/Vinyl Chlorides Enabled by Silylchloride‐Activated Mn Powders
Authors: Xü Minling , Wu Shigang , Zou Gang 
Published: July 2024

AbstractA room temperature Ni‐catalyzed Mn‐mediated homocoupling of (hetero)aryl and vinyl chlorides using Mn powders pre‐activated by trimethylsilylchloride (TMSCl) in DMA is reported. Large steric effects were observed while electronic influences from aryl chlorides proved to be rather small. High regioselectivity could be achieved between ortho‐Cl and para‐Cl/Br of aryl halides benefiting from the large steric effects. A double‐face role of TMSCl, i. e. activation of Mn powders but deactivation of nickel catalyst, was observed although TMSCl‐activated Mn powders appeared to be the privileged metallic reductant. Applications of the protocol have been demonstrated in a multigram synthesis of Daclatasvir.
Conspiracy blaming in the aftermath of group relative deprivation: The moderating role of national narcissism
Authors: Bertin Paul , Ionescu Octavia , Green Ricky , Abts Koen , Rogenhofer Julius , Delouvée Sylvain , Yzerbyt Vincent , Klein Olivier 
Published: July 2024

AbstractConspiracy beliefs entail a scapegoating function by attributing the consequences of crises, such as economic downturns, to the secret action of outgroups. While conspiracy beliefs have been described as reactions to economic threats, we argue that this factor alone is not sufficient. Rather, perceiving one's ingroup as unfairly deprived compared to other groups (i.e., group relative deprivation) might be key to explaining the situation in terms of secret, intentional wrongdoings. Furthermore, individuals high in national narcissism (i.e., a perceived lack of recognition of the ingroup's greatness), may be especially sensitive to this dynamic. Three pilot studies (N = 1237) attested the robustness of the link between group relative deprivation and conspiracy beliefs. Then, Study 1 (N = 812) revealed that the effect of group relative deprivation on conspiracy beliefs was moderated by national narcissism. In Study 2 (N = 728), we found effects of induced national narcissism and group relative deprivation on conspiracy beliefs in a fictitious setting. Study 3 (N = 846) replicated the moderation of national narcissism on the link between group relative deprivation and conspiracy beliefs at the cross‐sectional level. Overall, these studies provide evidence that conspiracy beliefs in reaction to group relative deprivation are especially likely among collective narcissists. We discuss the scapegoating function of conspiracy beliefs during crises.
Preparation of porous plate from municipal solid waste incineration fly ash and its application in a biofilm batch reactor
Authors: Wang Jing , Liu Han , Sun Chang‐Jung , Fang Weicheng 
Published: July 2024

AbstractThe reutilization of municipal solid waste incineration (MSWI) fly ash is a prominent area of research. This study focused on creating fly ash porous plate filler (FAPPF) by using techniques, such as water extraction, milling, component adjustment, and sintering. The produced FAPPF was then used to cultivate a biofilm for wastewater treatment. The key parameters included a two‐stage water extraction process with a 5:1 liquid‐to‐solid ratio; milling for 1, 2, and 4 h; component adjustment using waste glass powder, milled fly ash, palygorskite powder, and peanut shell powder at a 7:1:1:1 mass ratio; and sintering temperatures ranging from 700 to 1000°C. For the biofilm cultivation and treatment, this study employed semisimulated sewage in a sequencing biofilm batch reactor system. The results revealed the FAPPF had no heavy metal leaching, with a porosity of 48.53%–54.68%. Approximately 90% of its composition was derived from waste materials. Furthermore, scanning electron microscopy microanalysis revealed an internally stable liquid‐phase sintering structure. Finally, a mature biofilm developed in 21 days, achieving maximum removal rates of 95.48% for chemical oxygen demand and 78.4% for ammonia nitrogen. This article confirms the sustainable recycling potential of MSWI fly ash.
Research on coordinated control strategy for braking energy recovery of pure electric vehicles based on ESC
Authors: Li Min , Niu Xinbo , Cheng Yu 
Published: July 2024

AbstractTaking a rear‐wheel drive pure electric vehicle as the research object, considering the safety during braking and improving energy recovery rate, a study was conducted on the distribution strategy of front and rear axle braking force. During the braking process, the feedback braking force of the motor and the hydraulic braking force with an electronic stability controller (ESC) were coordinated and controlled, to ensure that the total required braking force was met. A fuzzy logic controller has been designed, with three variables of battery state of charge, vehicle speed, and braking intensity as inputs, and a modified motor braking ratio as output variable to prevent wheel lockup. Using Cruise software, a co‐simulation model was established with Amesim and Simulink, and simulation validation was conducted on the braking process and cycling conditions. The simulation results showed that the brake recovery strategy based on fuzzy control can effectively improve the vehicle's control performance and energy recovery rate compared to the Economic Commission of Europe regulation. The NEDC (New European Driving Cycle) working condition improved by 10.41% and the CLTC‐P (China Light‐duty Vehicle Test Cycle‐passenger) working condition improved by 10.57%. Effectively improving power consumption per 100 km, NEDC decreased by 1.81% and CLTC‐P decreased by 2.62%.
In vitro, in vivo, and in silico evidence for the use of plant pigments betalains as potential nutraceuticals against Alzheimer's disease
Authors: Martínez‐Rodríguez Pedro , Henarejos‐Escudero Paula , Hernández‐García Samanta , Sánchez‐Ferrer Álvaro , Gandía‐Herrero Fernando 
Published: July 2024

AbstractAnti‐amyloidogenic properties of plant pigments betalains as potential nutraceuticals against Alzheimer's disease have been screened using 24 pure molecules. Twenty‐two betalains reduced amyloid aggregation in vitro, eight of them up to 100%, with IC50 values in the micromolar range. Atomic force and transmission electron microscopy images showed the typical fibrils associated with Alzheimer's disease and how betalains avoid its formation. Neuroprotection after ingestion was supported by in vivo experiments with Caenorhabditis elegans. Indoline‐betacyanin was the most effective molecule by significantly improving the chemotactic behavior of the CL2355 strain, a model of Alzheimer's disease. Furthermore, in‐depth molecular docking analyses revealed that the pigments interact with the N‐terminal region of the amyloid peptide. This work is the most comprehensive study in the field and provides in vitro, in vivo, and in silico evidence for the use of betalains as nutraceuticals of relevance in the prevention of Alzheimer's disease.
Association of tumor growth rate with overall survival and recurrence among patients with laryngeal squamous cell carcinoma
Authors: Zhang Faye G. , Viswanathan Shankar , Zhang Chenxin , Smith Richard V. , Schiff Bradley A. , Ow Thomas J. , Garg Madhur K. , Kabarriti Rafi , Mehta Vikas 
Published: July 2024

AbstractBackgroundDelay in time to treatment initiation (TTI) is associated with worsened survival outcomes in laryngeal squamous cell carcinoma (LSCC). It is unclear whether this is due to tumor growth or an increased risk of metastatic disease.MethodsThis retrospective cohort study at one academic center included patients with LSCC who underwent radiotherapy/chemoradiotherapy between 2005 and 2017. We examined the association between tumor growth rate (TGR) and survival outcomes.ResultsAmong 105 patients (mean age, 63.8 ± 11.1 years; 72% male), the threshold between “slow‐growing” and “fast‐growing” tumors was >0.036 mL/day (survival) and >0.082 mL/day (recurrence). Faster growth was associated with worse overall survival (OS) (hazard ratio, 1.97; 95% confidence interval [CI], 0.94–4.13) and increased recurrence (odds ratio, 9.10; 95% CI, 2.40–34.4).ConclusionsTGR >0.036 mL/day during TTI was associated with decreased OS, and >0.082 mL/day was associated with increased recurrence. Tumor measurement in patients experiencing delay may identify those who could benefit from escalated therapy.