bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unfaithful brands: How brand attachment can lead to negative responses to influencer marketing campaigns
Authors: Bentley Kara , Rajagopal Priyali , Kulow Katina 
Published: July 2024

AbstractThe use of influencer marketing campaigns has increased exponentially in recent years as brands have embraced such campaigns in order to capitalize on the relationships that social media influencers (SMIs) have built with their followers as a means of increasing brand awareness and sales. Although influencer marketing is extensively utilized in practice, much is still unknown about the effects of these campaigns, including potential downsides and audience‐level variables that could moderate their success. In the current research, we find that partnering with SMIs is perceived as a norm violation for consumers with a high brand attachment, negatively impacting consumption intentions. Across five studies, we show that social media posts originating from an SMI, as opposed to the brand, lead to lower purchase intentions and willingness to pay for consumers with a high brand attachment. Additionally, we consider several moderators to this effect, including the salience of the sponsorship and consumers' attachment to the SMI. We also provide process evidence by documenting that perceptions of a norm violation mediate these effects.
Efficacy of chemically induced human hepatic progenitor cells from diseased liver against nonalcoholic steatohepatitis model
Authors: Miyamoto Daisuke , Matsuguma Kunihito , Nagai Kazuhiro , Miyoshi Takayuki , Hara Takanobu , Matsushima Hajime , Soyama Akihiko , Ochiya Takahiro , Miyazaki Yasushi , Eguchi Susumu 
Published: July 2024

AbstractBackgroundNumerous chemical reprogramming techniques have been reported, rendering them applicable to regenerative medicine research. The aim of our study was to evaluate the therapeutic potential of human CLiP derived from clinical specimens transplanted into a nonalcoholic steatohepatitis (NASH) mouse model of liver fibrosis.MethodsWe successfully generated chemically induced liver progenitor (CLiP), which exhibited progenitor‐like characteristics, through stimulation with low‐molecular‐weight compounds. We elucidated their cell differentiation ability and therapeutic effects. However, the therapeutic efficacy of human CLiP generated from clinical samples on liver fibrosis, such as liver cirrhosis, remains unproven.ResultsFollowing a 4 week period, transplanted human CLiP in the NASH model differentiated into mature hepatocytes and demonstrated suppressive effects on liver injury markers (i.e., aspartate transaminase and alanine transaminase). Although genes related to inflammation and fat deposition did not change in the human CLiP transplantation group, liver fibrosis‐related factors (Acta2 and Col1A1) showed suppressive effects on gene expression following transplantation, with approximately a 60% reduction in collagen fibers. Importantly, human CLiP could be efficiently induced from hepatocytes isolated from the cirrhotic liver, underscoring the feasibility of using autologous hepatocytes to produce human CLiP.ConclusionOur findings demonstrate the effectiveness of human CLiP transplantation as a viable cellular therapy for liver fibrosis, including NASH liver. These results hold promise for the development of liver antifibrosis therapy utilizing human CLiP within the field of liver regenerative medicine.
Improvement and exacerbation of multiple disparities in sexually transmitted infections among children and adolescents aged 6–22 years: An analysis of national surveillance data from 2013 to 2021
Authors: Zhang Yi , Geng Mengjie , Xing Yi , Ren Xiang , Chen Li , Liu Jieyu , Song Xinli , Qin Yang , Wang RuoLin , Jiang Jianuo , Guo Tongjun , Yuan Wen , Ma Yinghua , Ma Jun , Wang Liping , Song Yi , Dong Yanhui 
Published: July 2024

AbstractTo investigate the progress of disparities in human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS), gonorrhea, and syphilis among children and adolescents aged 6–22 years in China during 2013–2021. A total of 614 325 cases data were extracted from the Chinese Information System for Infectious Diseases Control and Prevention during 2013–2021. Puberty health education data were drew from the Student Health Surveillance in 2021. Disparity patterns and average annual percentage changes (AAPCs) in sexually transmitted infections (STIs) incidence or new cases in China were examined using descriptive statistics and joinpoint regression. The incidence across 345 cities was stratified by gross domestic product (GDP). Between 2013 and 2021, there were 614 325 reported cases of HIV/AIDS, gonorrhea, and syphilis among children and adolescents aged 6–22, with an annual average incidence of 24.0967 per 100 000. The expansion of HIV/AIDS has halted, yet the surge in gonorrhea and syphilis remains notably pronounced. The ratio of male to female AIDS incidence increased from 2.75 (2.60, 2.90) to 7.13 (6.68, 7.62), but that of syphilis changed from 0.33 (0.32, 0.34) to 0.56 (0.55, 0.57). Students and out‐of‐school individuals aged 13–15 experienced a notably high increase in STI cases, surpassing other age groups, with an average annual percentage increase of 29.2% and 26.3%, respectively. Nonstudents consistently had a higher incidence rate than students, with an IRR reaching 31.80 (31.24, 32.37) in 2021. A noticeable clustering pattern of new cases emerged in the southeastern region of the Heihe‐Tengchong line, extending inland from the coastal areas. Districts and counties with lower rates of puberty sexual health education tended to have higher average STI incidence rates. At the prefecture and city levels, there was a noticeable upward trend on average STI incidence rates in cities with per capita GDPs. Strategies to address those disparities include promoting equitable health education, and widespread sexual health education, particularly in areas with limited access to education and experiencing rapid economic development. The effectiveness of sexual health education intervention needs to be further evaluated in well‐designed studies.
Developed Rhizobium Strains Enhance Soil Fertility and Yield of Legume Crops in Haryana, India
Authors: Shah Ikbal , Sarim Khan M. , Sikka Virendra K. , Dudeja Surjit S. , Gahlot Dharmender K. 
Published: July 2024

ABSTRACTThree strains of Gram‐negative bacterium, Rhizobium, were developed by gamma (γ)‐irradiation random mutagenesis. The developed strains were evaluated for their augmented features for symbiotic association, nitrogen fixation, and crop yield of three leguminous plants—chickpea, field‐pea, and lentil—in agricultural fields of the northern Indian state of Haryana. Crops treated with developed mutants exhibited significant improvement in plant features and the yield of crops when compared to the control‐uninoculated crops and crops grown with indigenous or commercial crop‐specific strains of Rhizobium. This improvement was attributed to generated mutants, MbPrRz1 (on chickpea), MbPrRz2 (on lentil), and MbPrRz3 (on field‐pea). Additionally, the cocultured symbiotic response of MbPrRz1 and MbPrRz2 mutants was found to be more pronounced on all three crops. The statistical analysis using Pearson's correlation coefficients revealed that nodulation and plant biomass were the most related parameters of crop yield. Among the effectiveness of developed mutants, MbPrRz1 yielded the best results for all three tested crops. Moreover, the developed mutants enhanced macro‐ and micronutrients of the experimental fields when compared with fields harboring the indigenous rhizobial community. These developed mutants were further genetically characterized, predominantly expressing nitrogen fixation marker, nifH, and appeared to belong to Mesorhizobium ciceri (MbPrRz1) and Rhizobium leguminosarum (both MbPrRz2 and MbPrRz3). In summary, this study highlights the potential of developed Rhizobium mutants as effective biofertilizers for sustainable agriculture, showcasing their ability to enhance symbiotic relationships, crop yield, and soil fertility.
Skin α‐Synuclein Seeding Activity in Patients with Type 1 Gaucher Disease
Authors: LoPiccolo Mary Kate , Wang Zerui , Eshed Gadi Maayan , Fierro Luca , Stauffer Chanan , Wang Kelly , Zhang Jing , Tatsuoka Curtis , Balwani Manisha , Zou Wen‐Quan , Alcalay Roy N. 
Published: July 2024

AbstractBackgroundPatients with type 1 Gaucher disease (GD1) have a significantly increased risk of developing Parkinson's disease (PD).ObjectiveThe objective of this study was to evaluate skin α‐synuclein (αSyn) seeding activity as a biomarker for GD1‐related PD (GD1‐PD).MethodsThis single‐center study administered motor and cognitive examinations and questionnaires of nonmotor symptoms to adult patients with GD1. Optional skin biopsy was performed for skin αSyn seed amplification assay (αSyn SAA) using real‐time quaking‐induced conversion assay.ResultsForty‐nine patients were enrolled, and 36 underwent skin biopsy. Two study participants had PD. Ten participants were αSyn SAA positive (27.8%), 7 (19.4%) were intermediate, and 19 (52.8%) were negative. Positive αSyn seeding activity was observed in the single GD1‐PD case who consented to biopsy. αSyn SAA positivity was associated with older age (p = 0.043), although αSyn SAA positivity was more prevalent in patients with GD1 than historic controls.ConclusionsLongitudinal follow‐up is required to determine whether skin αSyn seeding activity can be an early biomarker for GD1‐PD. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Technical note: A GPU‐based shared Monte Carlo method for fast photon transport in multi‐energy x‐ray exposures
Authors: Zhou Yiwen , Deng Wenxin , Kang Jing , Xia Jinqiu , Yang Yingjie , Li Bin , Zhang Yuqin , Qi Hongliang , Wu WangJiang , Qi Mengke , Zhou Linghong , Ma Jianhui , Xu Yuan 
Published: July 2024

AbstractBackgroundThe Monte Carlo (MC) method is an accurate technique for particle transport calculation due to the precise modeling of physical interactions. Nevertheless, the MC method still suffers from the problem of expensive computational cost, even with graphics processing unit (GPU) acceleration. Our previous works have investigated the acceleration strategies of photon transport simulation for single‐energy CT. But for multi‐energy CT, conventional individual simulation leads to unnecessary redundant calculation, consuming more time.PurposeThis work proposes a novel GPU‐based shared MC scheme (gSMC) to reduce unnecessary repeated simulations of similar photons between different spectra, thereby enhancing the efficiency of scatter estimation in multi‐energy x‐ray exposures.MethodsThe shared MC method selects shared photons between different spectra using two strategies. Specifically, we introduce spectral region classification strategy to select photons with the same initial energy from different spectra, thus generating energy‐shared photon groups. Subsequently, the multi‐directional sampling strategy is utilized to select energy‐and‐direction‐shared photons, which have the same initial direction, from energy‐shared photon groups. Energy‐and‐direction‐shared photons perform shared simulations, while others are simulated individually. Finally, all results are integrated to obtain scatter distribution estimations for different spectral cases.ResultsThe efficiency and accuracy of the proposed gSMC are evaluated on the digital phantom and clinical case. The experimental results demonstrate that gSMC can speed up the simulation in the digital case by ∼37.8% and the one in the clinical case by ∼20.6%, while keeping the differences in total scatter results within 0.09%, compared to the conventional MC package, which performs an individual simulation.ConclusionsThe proposed GPU‐based shared MC simulation method can achieve fast photon transport calculation for multi‐energy x‐ray exposures.
ASPEN survey of parenteral nutrition access issues: How the system fails the patient
Authors: Mirtallo Jay M. , Allen Penny , Book Wendy M. , Hennessy Kathryn , Bond Bettiemarie , Gore Beth 
Published: July 2024

AbstractBackgroundProduct shortages and a lack of qualified providers to manage care may impact the safety and efficacy of parenteral nutrition (PN). This survey assessed the frequency and extent to which limitations to PN‐related access affects patients.MethodsOutpatient/patients receiving home PN were surveyed. Questions were developed to characterize the population and determine the extent and severity of PN access issues with components, devices, healthcare professionals, and transfers of care. Reimbursement issues surveyed included insurance coverage, contribution of healthcare costs to annual income, and the extent to which adjunctive therapy was reimbursed. Burdens surveyed included impact on disease symptoms and medical outcomes as well as the types and frequency of medical or system errors experienced, adverse events, or resultant nutrition problems.ResultsRespondents (N = 170) were well educated, rented or owned their own home, and were either employed or retired. All age populations were represented. Patients made frequent contact with care providers. Most were able to manage PN costs but feared losing insurance or changes to insurance. Patients used additional prescribed therapies that are poorly covered by insurance. Patients reported symptoms or exacerbation of disease, development or worsening of malnutrition, and episodes of nutrient deficiency. Patients noted errors occur, especially during periods of transitions of care, when they also often encounter clinicians with little understanding of PN. These are high‐acuity patients who have difficulty finding providers for their care.ConclusionThis patient survey provides evidence that access issues can result in the “failure of the PN system” to assure care is consistently safe and effective.
FFT‐based computational micromechanics with Dirichlet boundary conditions on the rotated staggered grid
Authors: Risthaus Lennart , Schneider Matti 
Published: July 2024

AbstractImposing nonperiodic boundary conditions for unit cell analyses may be necessary for a number of reasons in applications, for example, for validation purposes and specific computational setups. The work at hand discusses a strategy for utilizing the powerful technology behind fast Fourier transform (FFT)‐based computational micromechanics—initially developed with periodic boundary conditions in mind—for essential boundary conditions in mechanics, as well, for the case of the discretization on a rotated staggered grid. Introduced by F. Willot into the community, the rotated staggered grid is presumably the most popular discretization, and was shown to be equivalent to underintegrated trilinear hexahedral elements. We leverage insights from previous work on the Moulinec–Suquet discretization, exploiting a finite‐strain preconditioner for small‐strain problems and utilize specific discrete sine and cosine transforms. We demonstrate the computational performance of the novel scheme by dedicated numerical experiments and compare displacement‐based methods to implementations on the deformation gradient.
Comparing lignin and spent coffee grounds as bio‐fillers in PLA 3D‐printable filaments
Authors: Lage‐Rivera Silvia , Ares‐Pernas Ana , Dopico‐García M. Sonia , Covas José , Abad María‐José 
Published: July 2024

AbstractMaterial extrusion additive manufacturing is increasingly popular but requires new materials to expand its industrial applicability. This study compares the effects of two bio‐fillers (lignin and spent coffee grounds (SCG)) in a bio‐polymer matrix, polylactic acid (PLA). The bio‐fillers aim to enhance the sustainability of the resulting composites, tune their physical properties (rheology, thermal stability, mechanical resistance and water absorption) and improve 3D‐printability by reducing the temperature at the nozzle. The composite with 15 wt.% SCG exhibited an elongation at break of 22.95% (vs. 8.42% for PLA), a printing temperature of 180°C (vs. 215°C for PLA) and a water absorption after 6 weeks immersion in water of 18.77 wt.% (vs. 5.04 wt.% of PLA), suggesting applications like hydroponic farming. Moreover, small amounts of SCG protected the composite against thermo‐oxidative degradation during extrusion, while lignin enhanced the thermal stability of the composite.Highlights
15 wt.% SCG improved PLA ductility (elongation at break 22.9% vs. PLA's 8.4%).
Lower printing temperature (180 vs. 215°C for PLA) was achieved with 15 wt.% SCG.
SCG protects composite from thermo‐oxidative degradation.
15 wt.% SCG in PLA absorbs 18.77% water after 6 weeks (vs. 5.04% of PLA).
Lignin boosts thermal stability of PLA composite.
Relictithismia: An underground fairy lantern
Authors: Suetsugu Kenji 
Published: July 2024

Societal Impact StatementThe discovery of a new genus within the family Thismiaceae, known as fairy lanterns, marks a significant scientific milestone in Japan, a country renowned for its botanical research. The unearthing of a new genus, especially in a well‐documented flora like Japan, is both rare and monumental. Unlike other fairy lanterns that bloom under leaf litter and can be easily overlooked, the new genus and species, Relictithismia kimotsukiensis, often does not even emerge above the surface of the soil when flowering. This captivating characteristic not only enriches our knowledge of botanical diversity but also emphasizes the importance of preserving natural habitats that harbor such rare species.SummaryThe family Thismiaceae, known as “fairy lanterns”, is distinguished by its urn‐ or bell‐shaped, glasswork‐like flowers with basally fused tepals and its dependence on specific fungi for carbon. A new genus and species, Relictithismia kimotsukiensis, has been discovered in southern Japan. This species is notable for its unique anther‐stigma contact, hitherto unreported in the other Thismiaceae. Unlike typical fairy lanterns that bloom just above the leaf litter, Relictithismia often flowers beneath it. The underground habit is potentially associated with self‐pollination. The discovery of Relictithismia enhances our understanding of evolutionary pathways within the Thismiaceae, as it possesses characteristics previously thought to be unique to Thismia (the annulus with drooping stamens) as well as traits found in other genera (free stamens without expanded connectives). This paper reviews the morphology, ecology, and evolutionary history of Relictithismia, offering insights into the peculiarities of these enigmatic plants.
Optimized algorithm for speed‐of‐sound‐based infant sulfur hexafluoride multiple‐breath washout measurements
Authors: Wyler Florian , Manogaran Thuvarakha , Monney Nathalie , Salem Yasmin , Steinberg Ruth , Kentgens Anne‐Christianne , Jacobs Carvern , Chaya Shaakira , Sena Carla Rebeca da Silva , Künstle Noëmi , Gorlanova Olga , Yammine Sophie , Gray Diane M. , Frey Urs , Oestreich Marc‐Alexander , Latzin Philipp 
Published: July 2024

AbstractIntroductionMajor methodological issues with the existing algorithm (WBreath) used for the analysis of speed‐of‐sound‐based infant sulfur hexafluoride (SF6) multiple‐breath washout (MBW) measurements lead to implausible results and complicate the comparison between different age groups and centers.MethodsWe developed OASIS—a novel algorithm to analyze speed‐of‐sound‐based infant SF6 MBW measurements. This algorithm uses known context of the measurements to replace the dependence of WBreath on model input parameters. We validated the functional residual capacity (FRC) measurement accuracy of this new algorithm in vitro, and investigated its use in existing infant MBW data sets from different infant cohorts from Switzerland and South Africa.ResultsIn vitro, OASIS managed to outperform WBreath at FRC measurement accuracy, lowering mean (SD) absolute error from 5.1 (3.2) % to 2.1 (1.6) % across volumes relevant for the infant age range, in variable temperature, respiratory rate, tidal volume and ventilation inhomogeneity conditions. We showed that changes in the input parameters to WBreath had a major impact on MBW results, a methodological drawback which does not exist in the new algorithm. OASIS produced more plausible results than WBreath in longitudinal tracking of lung clearance index (LCI), provided improved measurement stability in LCI over time, and improved comparability between centers.DiscussionThis new algorithm represents a meaningful advance in obtaining results from a legacy system of lung function measurement by allowing a single method to analyze measurements from different age groups and centers.
Antibiotics and beyond: Unraveling the dynamics of bronchopulmonary dysplasia in very preterm infants
Authors: Menegolla Marina P. , Silveira Rita C. , Görgen Antônio R H , Gandolfi Fernanda E. , Procianoy Renato S. 
Published: July 2024

AbstractBackgroundBronchopulmonary dysplasia (BPD) remains a significant challenge in neonatal care. Prenatal inflammation and neonatal sepsis contribute to the multifactorial nature of BPD. A potential association between empirical antibiotic therapy and BPD risk has been proposed due to microbiota dysbiosis in very low birth weight premature infants.MethodsA single centered retrospective cohort study of preterm infants (24–32 weeks gestation) from 2014 to 2021. The study compared groups that received empirical antibiotics in the first days of life and those that did not receive any antibiotic in the first days of life. The primary outcomes studied were BPD, death, and the combined outcome of BPD/death. Statistical analysis employed t‐tests, Mann‐Whitney U, Chi‐square, and logistic regression.ResultsOf 454 preterm infants, 61.5% received antibiotics. This group had lower gestational age, birth weight, and Apgar scores. Antibiotic use was associated with higher incidence of BPD (35.5% vs. 10.3%), death (21.5% vs. 8.6%), and combined outcomes (54.5% vs. 18.3%). In multivariate analysis, antibiotic use independently associated with BPD (OR 2.58, p < 0.001) and combined outcome BPD/death (OR 2.06, p < 0.02). Antenatal corticosteroids provided protection against BPD, but not mortality.ConclusionThis study suggests an association between early empirical antibiotic use and BPD in preterm infants, emphasizing the need for judicious antibiotic practices in neonatal care.
Cumulative asparagine to aspartate deamidation fails to perturb γD‐crystallin structure and stability
Authors: Guseman Alex J. , González Jeremy J. , Yang Darian , Gronenborn Angela M. 
Published: July 2024

AbstractDeamidation frequently is invoked as an important driver of crystallin aggregation and cataract formation. Here, we characterized the structural and biophysical consequences of cumulative Asn to Asp changes in γD‐crystallin. Using NMR spectroscopy, we demonstrate that N‐ or C‐terminal domain‐confined or fully Asn to Asp changed γD‐crystallin exhibits essentially the same 1H‐15N HSQC spectrum as the wild‐type protein, implying that the overall structure is retained. Only a very small thermodynamic destabilization for the overall Asn to Asp γD‐crystallin variants was noted by chaotropic unfolding, and assessment of the colloidal stability, by measuring diffusion interaction parameters, yielded no substantive differences in association propensities. Furthermore, using molecular dynamics simulations, no significant changes in dynamics for proteins with Asn to Asp or iso‐Asp changes were detected. Our combined results demonstrate that substitution of all Asn by Asp residues, reflecting an extreme case of deamidation, did not affect the structure and biophysical properties of γD‐crystallin. This suggests that these changes alone cannot be the major determinant in driving cataract formation.