bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bone morphogenetic protein‐2–impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect
Authors: DeConde Adam S. , Sidell Douglas , Lee Min , Bezouglaia Olga , Low Kyle , Elashoff David , Grogan Tristan , Tetradis Sotirios , Aghaloo Tara , St. John Maie 
Published: April 2013

Objectives/HypothesisTo test the osteoregenerative potential and dosing of bone morphogenetic protein‐2 (BMP‐2)‐impregnated biomimetic scaffolds in a rat model of a mandibular defect.Study DesignProspective study using an animal model.MethodsVaried doses of BMP‐2 (0.5, 1, 0.5, 0.5 in microspheres, 5, and 15 μg) were absorbed onto a biomimetic scaffold. Scaffolds were then implanted into marginal mandibular defects in rats. Blank scaffolds and unfilled defects were used as negative controls. Two months postoperatively, bone healing was analyzed with microcomputerized tomography (microCT).ResultsMicroCT analysis demonstrated that all doses of BMP‐2 induced successful healing of marginal mandibular defects in a rat mandible. Increasing doses of BMP‐2 on the scaffolds produced increased tissue healing, with 15 μg demonstrating significantly more healing than all other dosing (P < .01).ConclusionsBMP‐2–impregnated biomimetic scaffolds successfully induce bone healing in a marginal mandibular defect in the rat. Percentage healing of defect, percentage of bone within healed tissue, and total bone volume are all a function of BMP‐2 dosing. There appears to be an optimal dose of 5 μg beyond which there is no increase in bone volume.Level of EvidenceNA
Bohrarbeiten für Gefrierschächte in Russland – Bergwerk Ust Jaiwa
Authors: Ahlbrecht Thomas , Schilder Ralph 
Published: April 2013

AbstractNach einer Übersicht über den Kalibergbau in Russland und die Kapazitätsplanungen des russischen Unternehmens Uralkali berichtet der Beitrag über die Projektplanung für zwei Gefrierschächte für das neue Kalibergwerk Bergwerk Nr. 5 “Ust Jaiwa”. Die beiden Schächte mit einem lichten Durchmesser von jeweils 8 m befinden sich in einem Abstand von 150 m. Die Endteufen betragen 522 m bzw. 422 m. Das wasserführende Deckgebirge wird bis in eine Teufe von 245 m gefroren. Hierfür werden pro Schacht 45 Gefrierlöcher mit hohen Anforderungen an die Bohrgenauigkeit benötigt.Drilling works for freezing shafts at the Ust Jaiwa mine in RussiaAfter an overview of potash mining in Russia and the capacity planning or the Russian company Uralkali, the article reports on the project design for two freezing shafts at the new potash mine No. 5 “Ust Jaiwa”. The two shafts, each with a clear diameter of 8 m, are spaced 150 m apart with final depths of 522 m and 422 m. The aquiferous overburden is being frozen down to a depth of 245 m. This requires 45 freezing holes for each shaft with a stringent specification for drilling accuracy.
bauma 2013 – Plattform für Neuheiten
Authors: Richter Helmut 
Published: April 2013

AbstractVom 15. bis 21. April 2013 öffnet die weltgrößte Baumaschinenmesse wieder ihre Pforten und erwartet in München einen hohen Besucherstrom aus der ganzen Welt. Die bauma 2013, Internationale Fachmesse für Baumaschinen, Baustoffmaschinen, Bergbaumaschinen, Baufahrzeuge und Baugeräte, findet dieses Jahr zum 30. Mal statt. Über 3.300 Aussteller präsentieren auf einer erweiterten Ausstellungsfläche von 570.000 m2 neue und bewährte Produkte der internationalen Bau‐, Baustoff‐ und Bergbaumaschinenindustrie.Obwohl die Flächenkapazitäten gegenüber 2010 noch einmal erweitert wurden, ist die bauma einmal mehr an ihre Grenzen gestoßen. Die Wartelisten sind noch immer lang, die Messemacher konnten erneut nicht alle Teilnahmewünsche erfüllen. Die Anziehungskraft dieser Veranstaltung ist international ohne gleichen. Sie ist nicht nur die größte Bau‐ und Baustoffmaschinenmesse der Welt, sondern auch die, auf der die meisten Weltneuheiten zu sehen sind. Effizienz, Umweltverträglichkeit und Arbeitssicherheit werden einige der vorherrschenden Themen sein. Dass sie mehr als nur neue Impulse für die Geschäftsentwicklungen gibt, davon geht Joachim Schmid, Geschäftsführer des Fachverbands Bau‐ und Baustoffmaschinen aus: “Die bauma ist mehr – sie ist der Gradmesser für die zukünftige Marktentwicklung”.bauma 2013 – Platform for innovations. The largest exhibition of construction machinery in the world will open its doors from 15 to 21 April 2013 in Munich and expects a flood of visitors from all over the world. bauma 2013, the International Trade Fair for Construction Machinery, Building Material Vehicles, Mining Machines, Construction Vehicles and Construction Equipment, is taking place for the 30th time this year. Over 3,300 exhibitors will be presenting new and proven products of the international construction, construction materials and mining machinery industry in an enlarged area of 570,000 m2.Although the available area has again been increased compared to 2010, the bauma has once again met its limits. The waiting lists are still long and the organisers could once again not satisfy all the demand for space. The pulling power of this event is international like no other. It is not only the largest event for construction and construction materials machinery, but also where the most worldwide innovations are to be seen. Efficiency, environmental compatibility and occupational safety will be some of the main themes. The event provides more than just new impulses for business development, states Joachim Schmid, managing director of the construction and construction machinery association: “the bauma is more – it is the indicator of future market development”.
A note on the upper bound in SA AMG convergence analysis
Authors: Guo Cui , Xiang Hua 
Published: April 2013

SUMMARYIn [M. Brezina, P. Vaněk and P. S. Vassilevski, An improved convergence of smoothed aggregation algebraic multigrid, Numer. Linear Algebra Appl., 19 (2012), pp. 441–469], a uniform convergence bound for smoothed aggregation algebraic multigrid with aggressive coarsening and massive polynomial prolongator and multigrid smoothers is established provided that the number of smoothing steps is equal to the coarsening ratio parameter ν. The final convergence estimate needs the uniform bound for the constant Cν ∕ (2ν + 1). In this note, we give an improved upper bound. Copyright © 2013 John Wiley & Sons, Ltd.
Discontinuous Galerkin and multiscale variational schemes for a coupled damped nonlinear system of Schrödinger equations
Authors: Asadzadeh M. , Rostamy D. , Zabihi F. 
Published: April 2013

AbstractIn this article, we study a streamline diffusion‐based discontinuous Galerkin approximation for the numerical solution of a coupled nonlinear system of Schrödinger equations and extend the resulting method to a multiscale variational scheme. We prove stability estimates and derive optimal convergence rates due to the maximal available regularity of the exact solution. In the weak formulation, to make the underlying bilinear form coercive, it was necessary to supply the equation system with an artificial viscosity term with a small coefficient of order proportional to a power of mesh size. We justify the theory by implementing an example of an application of the time‐dependent Schrödinger equation in the coupled ultrafast laser. © 2013 Wiley Periodicals, Inc. Numer Methods Partial Differential Eq, 2013
Variable characteristics with insulin assays
Authors: Kalathil S , Napier C , Pattman SJ , Wark G , Abouglila K , James RA 
Published: April 2013

AbstractFactitious hypoglycaemia is a challenging diagnosis to confirm. Evaluation of surreptitious human insulin use can be distinguished from endogenous insulin excess by existing biochemical assays. However, the increasing use of insulin analogues poses a challenge because commercially available insulin assays detect these with varying accuracy and precision.Insulin analogues are increasingly used in diabetes management and the case outlined here highlights the variations in assay. Initially, the local assay (ELISA kit – Dako, Copenhagen) failed to detect a significant concentration of insulin (<6pmol/L; range 9.6–65.4pmol/L) which an external reference laboratory subsequently detected using the Mercodia Iso‐insulin two‐site immunoassay (Uppsala, Sweden).The key analytical point is the recognition that different immunoassays detect insulin analogues to varying degrees. Clinical teams need to consider this if such cases are to be recognised. Following recent media reports where surreptitious insulin administration may be implicated in inpatient mortality, this knowledge is crucial to empower us to accurately diagnose all cases of unexplained hypoglycaemia. Copyright © 2013 John Wiley & Sons. Practical Diabetes 2013; 30(3): 118–120
Preanalytical sample handling of venous blood: how to ensure your glucose measurement is accurate and reliable
Authors: Steele AM , Wensley KJ , Brewer E , Shields BM , Hattersley AT , McDonald TJ 
Published: April 2013

AbstractMeasurement of blood glucose is a standard biochemical test requiring optimum preanalytical sample handling. Glucose measured in plasma from tubes containing sodium fluoride is recommended but serum from serum‐gel tubes may be used in research situations. To help inform best practice, we assessed glucose stability in plasma and serum samples subjected to different preanalytical conditions.Fasting samples were taken from 10 non‐diabetic volunteers into fluoride/EDTA and serum‐gel tubes. Whole blood samples were pipetted into aliquots, placed on crushed ice or left at room temperature. Aliquots were centrifuged at 0, 2, 12, 24, and 48 hours.When neither ice nor centrifuge were available, plasma glucose was stable for 48 hours (96% of baseline); serum glucose degraded to 8% of baseline. When centrifuged and left at room temperature, plasma glucose was stable for 48 hours (101% of baseline) but, by 24 hours, serum glucose had fallen (94% of baseline). The result of un‐centrifuged plasma on ice was stable (96% of baseline) at 48 hours; serum glucose had dropped to 92% of baseline by 12 hours. Plasma glucose and serum glucose were constant for 48 hours when separated and placed on ice within 2 hours: plasma glucose 101% of baseline; serum glucose 100% of baseline. Separated serum resting on the serum plug fell to 94% of baseline by 12 hours at room temperature and to 92% of baseline by 48 hours on ice.Clinically, we recommend that glucose is measured on plasma taken from fluoride tubes. Analysis should be undertaken as soon as practicable. In the research setting, glucose can be measured on plasma or serum but samples must be centrifuged and chilled soon after venepuncture and analysed within 48 hours. Copyright © 2013 John Wiley & Sons. Practical Diabetes 2013; 30(3): 128–131
Obesity co‐morbidities and the obesity paradox
Authors: Haslam David 
Published: April 2013

AbstractIt is no surprise that obesity is associated with co‐morbidities including diabetes, cardiovascular disease, obstructive sleep apnoea and cancer, and that weight loss confers protection against their onset. Therefore it is counter‐intuitive that, although obesity is implicated in their cause, its presence seems to be protective against mortality once some of these conditions have occurred. ‘The idea that a known risk factor somehow transforms into a “protective” agent after an occurrence of a vascular clinical event is both surreal and troubling’.1 This phenomenon has been termed the ‘obesity paradox’ by many authorities.This article discusses the link between obesity and various long‐term illnesses, assesses the evidence surrounding the obesity paradox, and considers whether weight reduction, or the alternative – obesity‐related risk management while weight is maintained – is an appropriate goal in the elderly and in the presence of certain medical conditions. Copyright © 2013 John Wiley & Sons. Practical Diabetes 2013; 30(3): 132–135
Effect of Intravenous Zanamivir on Cardiac Repolarization
Authors: Lou Yu , Gan Jianjun , Peppercorn Amanda , Gould Elizabeth , Weller Steve , Piscitelli Stephen C. , Patel Parul 
Published: April 2013

Study ObjectiveTo assess the effect of a therapeutic and supratherapeutic intravenous dose of the neuraminidase inhibitor zanamivir onQTand rate‐correctedQTintervals.DesignRandomized, placebo‐controlled, single‐dose, four‐period, balanced crossover study.SettingClinical research unit.SubjectsForty healthy adults were randomized to receive intravenous zanamivir at two dose levels, oral moxifloxacin, and placebo; 38 subjects completed all four study treatments.InterventionSubjects were randomized to receive a single intravenous dose of zanamivir 600 mg (therapeutic dose) with oral moxifloxacin placebo, a single intravenous dose of zanamivir 1200 mg (supratherapeutic dose) with oral moxifloxacin placebo, oral moxifloxacin 400 mg (positive control) with intravenous zanamivir placebo, or intravenous zanamivir placebo with oral moxifloxacin placebo. Subjects crossed over to all other treatments, with each treatment separated by a 7‐day washout period.Measurements and Main ResultsZanamivir pharmacokinetics were dose proportional; the pharmacokinetic exposure from zanamivir 1200 mg was 2 times higher than that from 600 mg, the maximum dose under clinical evaluation. For both 600‐mg and 1200‐mg doses of intravenous zanamivir, the upper limit of the 90% confidence interval (CI) for the placebo‐adjusted mean change from baseline of theQTinterval corrected for heart rate using Fridericia's formula (ΔΔQTcF) was less than 10 msec at all time points. The sensitivity of the study to detect modest increases inQTinterval was established with the positive control, moxifloxacin. The maximum ΔΔQTcF value for zanamivir 1200 mg was 1.73 msec (90%CI–0.40 to 3.87 msec), which was observed within 30 minutes after dosing, and 11.21 msec (90% CI8.81–13.60) for moxifloxacin, observed at 4 hours after dosing. No relationship was observed between zanamivir serum concentration and ΔΔQTcF. Zanamivir was generally well tolerated, with very few adverse events; none were serious or severe.ConclusionIntravenous zanamivir does not affect cardiac repolarization. Accordingly, treatment with intravenous zanamivir does not require additional cardiac monitoring beyond the standard of care.
Thermokarst Processes and Depositional Events in a Tundra Lake, Northeastern Siberia
Authors: Biskaborn Boris K. , Herzschuh Ulrike , Bolshiyanov Dmitry Y. , Schwamborn Georg , Diekmann Bernhard 
Published: April 2013

ABSTRACTThe relationships between thermokarst activity, limnogeological processes and climate change in the Siberian Arctic are not well understood. The objective of this paper is to identify the factors controlling the patterns of deposition, using grain size distribution, organic content, elemental composition and mineralogical composition of a 137‐cm long sediment core with a maximum age of ~ 10.9 cal. kyr BP from Lake El'gene‐Kyuele in the tundra of northeastern Siberia. Eight fine sand layers are attributed to depositional events associated with thaw slump activity acting upon orthogonally oriented patterns of ice‐wedge networks in the ice‐rich permafrost on the NW margin of the lake catchment. Sr/Rb ratios, which correspond to the total feldspar and illite content, serve as high‐resolution grain size proxies. The Br content relates to the total organic carbon content, and the Fe/Mn ratio reflects the degree of oxidisation. Our results indicate a relationship between repeated phases of fine sand input and retrogressive thaw slumping dependent on hydroclimate variability and orthogonally oriented ice‐wedge networks within the catchment. Copyright © 2013 John Wiley & Sons, Ltd.
Incorporating into a Cα Go model the effects of geometrical restriction on Cα atoms caused by side chain orientations
Authors: Sugita Masatake , Kikuchi Takeshi 
Published: April 2013

ABSTRACTCoarse‐grained Go models have been widely used for studying protein‐folding mechanisms. Despite the simplicity of the model, these can reproduce the essential features of the folding process of a protein. However, it is also known that side chains significantly contribute to the folding mechanism. Hence, it is desirable to incorporate the side chain effects into a coarse‐grained Go model. In this study, to distinguish the effects of side chain orientation and to understand how these effects contribute to folding mechanisms, we incorporate into a Cα Go model not only heterogeneous contact energies but also geometrical restraints around two Cα atoms in contact with each other. We confirm that the heterogeneity of contact energies governs the folding pathway of a protein and that the geometric constraints attributed to side chains reproduce cooperative transitions in folding. Proteins 2013; 81:1434–1445. © 2013 Wiley Periodicals, Inc.
Folding of Top7 in unbiased all‐atom Monte Carlo simulations
Authors: Mohanty Sandipan , Meinke Jan H. , Zimmermann Olav 
Published: April 2013

ABSTRACTFor computational studies of protein folding, proteins with both helical and β‐sheet secondary structure elements are very challenging, as they expose subtle biases of the physical models. Here, we present reproducible folding of a 92 residue α/β protein (residues 3–94 of Top7, PDB ID: 1QYS) in computer simulations starting from random initial conformations using a transferable physical model which has been previously shown to describe the folding and thermodynamic properties of about 20 other smaller proteins of different folds. Top7 is a de novo designed protein with two α‐helices and a five stranded β‐sheet. Experimentally, it is known to be unusually stable for its size, and its folding transition distinctly deviates from the two‐state behavior commonly seen in natural single domain proteins. In our all‐atom implicit solvent parallel tempering Monte Carlo simulations, Top7 shows a rapid transition to a group of states with high native‐like secondary structure, and a much slower subsequent transition to the native state with a root mean square deviation of about 3.5 Å from the experimentally determined structure. Consistent with experiments, we find Top7 to be thermally extremely stable, although the simulations also find a large number of very stable non‐native states with high native‐like secondary structure. Proteins 2013; 81:1446–1456. © 2013 Wiley Periodicals, Inc.
Determinants of Diarrhoea in ‘Urban’ Slums of Dhaka and Adjacent Rural Areas: a Household‐level Analysis
Authors: Khan MMH , Zanuzdana Arina , Burkart Katrin , Krämer Alexander 
Published: April 2013

ABSTRACTDiarrhoeal diseases constitute an important public health problem in many developing countries including Bangladesh. This study aimed to report the household‐level determinants of diarrhoea using the baseline information of cohort studies conducted in 2008 and 2009. The variation of diarrhoea by 3‐month period was also reported. A total of 3,207 households were systematically selected from 12 slums in Dhaka and three rural villages located nearby. The highest prevalence of diarrhoea was found during the period of September to November (22.7%) and the lowest during December to February (9.2%). Slum households were more affected by diarrhoea as compared with the rural households (OR = 1.49; 95% CI = 1.06–2.08; p = 0.020). Other determinants namely provisional house, sharing water source, and sanitary, and use of surface water were also associated with a higher risk of diarrhoea. In conclusion, slum households suffered more from diarrhoea than rural populations. Moreover, the higher burden of diarrhoea were found to be strongly and persistently associated with adverse housing and environmental conditions. Public health strategies based on our findings are required to reduce the burden of diarrhoea in the study population. Particularly multilevel interdisciplinary actions are needed to improving the quality of housing, water, and sanitation facilities in urban slums of Dhaka, and similar settings elsewhere. Copyright © 2013 John Wiley & Sons, Ltd.
High‐pressure studies of topological insulators Bi2Se3, Bi2Te3, and Sb2Te3
Authors: Manjón F. J. , Vilaplana R. , Gomis O. , Pérez‐González E. , Santamaría‐Pérez D. , Marín‐Borrás V. , Segura A. , González J. , Rodríguez‐Hernández P. , Muñoz A. , Drasar C. , Kucek V. , Muñoz‐Sanjosé V. 
Published: April 2013

AbstractBi2Se3, Bi2Te3, and Sb2Te3 are narrow bandgap semiconductors with tetradymite crystal structure (R‐3m) which have been extensively studied along with their alloys due to their promising operation as thermoelectric materials in the temperature range between 300 and 500 K. Studies on these layered semiconductors have increased tremendously in the last years since they have been recently predicted and demonstrated to behave as 3D topological insulators. In particular, a number of high‐pressure studies have been done in the recent years in these materials. In this work we summarize the main results of the high‐pressure studies performed in this family of semiconductors to date. In particular, we review recent results that address the main characteristics of the pressure‐induced electronic topological transition and structural phase transitions observed in this family of compounds. Future high‐pressure studies to be performed on these 3D topological insulators are also commented.
Content‐boosted matrix factorization techniques for recommender systems
Authors: Nguyen Jennifer , Zhu Mu 
Published: April 2013

AbstractMany businesses are using recommender systems for marketing outreach. Recommendation algorithms can be either based on content or driven by collaborative filtering. We study different ways to incorporate content information directly into the matrix factorization approach of collaborative filtering. These content‐boosted matrix factorization algorithms not only improve recommendation accuracy, but also provide useful insights about the contents, as well as make recommendations more easily interpretable. © 2013 Wiley Periodicals, Inc. Statistical Analysis and Data Mining, 2013
A Thermodynamic Model for Representation Reaction Abilities of Structural Units in Full Composition Range of Fe–Si Binary Melts Based on the Atom–Molecule Coexistence Theory
Authors: Yang Xue‐min , Zhang Meng , Li Peng‐cheng , Li Jin‐yan , Zhang Jian 
Published: April 2013

AbstractA thermodynamic model for calculating the mass action concentrations of structural units in Fe–Si binary melts based on the atom–molecule coexistence theory, i.e., the AMCT–Ni model, has been developed and verified through comparing with the reported activities of both Si and Fe in the full composition range of Fe–Si binary melts at temperatures of 1693, 1773, 1873, and 1973 K from the literature. The calculated mass action concentration NSi of free Si or NFe of free Fe in the full composition range of Fe–Si binary melts has a good 1:1 corresponding relationship with the reported activity aR,Si of Si or aR,Fe of Fe relative to pure liquid Si(l) or Fe(l) as standard state. The calculated mass action concentration NSi of free Si has a good corresponding relationship with the calculated activity a%,Si of Si referred to 1 mass% of Si as standard state as well as the calculated activity aH,Si of Si relative to the hypothetical pure liquid Si(l) as standard state. The calculated activity a%,Si or aH,Si of Si is much greater than the calculated mass action concentration NSi of free Si in Fe–Si binary melts. The reaction abilities of both Si and Fe show a competitive or coupling relationship in Fe–Si binary melts at the above‐mentioned four temperatures. The calculated mass action concentrations Ni of six structural units as Fe, Si, Fe2Si, Fe5Si3, FeSi, and FeSi2 cannot show the linear relationship with the calculated equilibrium mole numbers ni in 100‐g Fe–Si binary melts simultaneously. A spindle‐type relationship between the calculated mass action concentration Ni and the calculated equilibrium mole number ni of FeSi and FeSi2 in Fe–Si binary melts has been found.