bluuebunny/crossref_metadata_2025_split huggingface dataset:
Exploring Proximal and Distal Factors of Dental Caries in Underserved Populations Utilizing Charitable Mobile Dental Services: A Cross-Sectional Study, Saudi Arabia
Authors: Gamar Elanbya May , Aloufi Nujud Ghazai , Alharbi Ahmed , Almurowbea Alanoud , Alrehaili Shuruq , Alaydaa Rawan , Shubayr Mosa , Elsayed Shadia A. , Ramadan AbdelRahman M. , Alsharif Alla 
Published: February 2025

Abstract
Objective This study aimed to assess and identify the associated proximal and distal factors of dental caries in underserved populations using charitable mobile dental services in Al Madinah Province, Saudi Arabia.
Materials and Methods A cross-sectional analytical study was conducted among adults aged ≥18 years attending a charitable mobile clinic in the rural areas of Al Madinah Province, Saudi Arabia, between June and September 2023. Calibrated dentists examined the dental caries among patients who completed a questionnaire.
Statistical Analysis Spearman's rho test, Mann–Whitney and Kruskal–Wallis tests, and negative binomial regression analyses were conducted.
Results Of the 414 participants, 195 (47%) were males, and the age median/interquartile range (IQR) was 39 (19) years. Caries were identified in 412 of the sample with a median (IQR) decayed, missing, and filled teeth (DMFT) score of 13 (9). Age showed a statistically significant positive association with DMFT scores (β = 0.015; rate ratio [RR] = 1.015; 95% confidence interval [CI]: [1.101, 1.02], p < 0.001) and likewise nationality and place of residence associated significantly with DMFT scores (β = −0.203; RR = 0.816; 95% CI: [0.676, 0.986], p = 0.035 and β = 0.161; RR = 1.175; 95% CI: [1.037, 1.331], p = 0.012, respectively). Educational level (university level) was negatively associated with DMFT scores (β = −0.079; RR = 0.924; 95% CI: [0.855, 0.998], p = 0.044). Visiting dentists was negatively associated with DMFT scores (β = −0.104; RR = 0.902; 95% CI: [0.858, 0.947], p < 0.001), but income, diabetes, hypertension, teeth brushing practice, use of fluoridated toothpaste, and acidic food consumption showed nonsignificant associations.
Conclusion This study highlights the significance of age, nationality, place of residence, educational level, and visiting dentists as factors associated with increases in DMFT scores, while income, oral hygiene practices, and certain chronic conditions showed no significant impact within this population.
Clinical Characteristics and Burden of IgG4-Related Disease in the United Arab Emirates
Authors: Namas Rajaie , Alawadhi Hamdan , AlMheiri Mahra , Eljabour Rema , Al Qassimi Sarah , Memisoglu Esat , Salvo Fulvio , Mubashir Asia , AlKhatib Amer , Chiha Maguy , Hegazin Safa , Masri Mohamad , Abuzakouk Mohamed , Elarabi Mohamed , Almarzooqi Ahlam , Ghosn Muriel 
Published: February 2025

Abstract
Background There is a scarcity of literature detailing the demographic and clinical data concerning immunoglobulin G4–related disease (IgG4-RD) within the population of the UAE.
Objective This retrospective follow-up study aimed to investigate the demographic and clinical characteristics of IgG4-RD in an Arab cohort receiving treatment at Cleveland Clinic Abu Dhabi.
Patients and Methods Data were collected from 28 Arab patients diagnosed with IgG4-RD at Cleveland Clinic Abu Dhabi between April 1, 2015 and May 31, 2023. The study employed rigorous inclusion and exclusion criteria, utilizing the American College of Rheumatology (ACR)/European Alliance of Associations for Rheumatology (EULAR) 2019 criteria for classification. Comprehensive analysis of electronic health records included demographics, clinical history, laboratory results, and treatment specifics. The study received ethical approval.
Results The median age of the patients at the time of initial symptoms was 42 ± 3 years (median ± standard deviation) and that at the time of diagnosis was 47 ± 4.6 years, with a 5-year lag period between initial clinical presentation and establishing a diagnosis. The most common symptoms were constitutional symptoms (71%) followed by low back pain experienced by 54% of patients due to mass effect. In terms of organ involvement, 89% of patients exhibited a single organ being affected. The kidney was the most frequently involved organ (46%). Treatment involved glucocorticoids, often combined with methotrexate and azathioprine, with rituximab.
Conclusion The study highlights unique features in the Arab population, including a younger median age and the absence of pancreatic involvement. The findings emphasize the need for a national registry to understand disease prevalence, raise awareness, and guide health care strategies for IgG4-RD.
Response Assessment after Neoadjuvant Chemoradiotherapy in Rectal Cancer
Authors: Chandramohan Anuradha , Augustine Antony , Hiriyanna Sneha , Natarajan Shobiga , Selvam Ajeet A. , Eapen Kurian C. , Yadav Saloni A. , Paul Joseph Chacko , Lakhani Aisha , Simon Betty , Eapen Anu 
Published: February 2025

AbstractManagement of locally advanced rectal cancer is complex, and magnetic resonance imaging (MRI) findings play a central role in treatment decisions. While neoadjuvant chemoradiotherapy significantly improved local recurrence rates, newer treatment modalities, such as total neoadjuvant chemotherapy, improved distant control. They significantly improved pathological complete response rates, enabling organ preservation in more patients. MRI is the best imaging modality to assess treatment response. MRI aids in assessing operability, predicts surgical outcomes following neoadjuvant treatment, and aids in identifying patients' eligible for organ preservation and their follow-up. In this review, we discuss imaging techniques and interpretation of rectal cancer MRI following neoadjuvant treatment, provide a structured reporting template for response assessment MRI, and detail how imaging findings influence treatment decisions.
ALK-Rearranged Renal Cell Carcinoma: A Case Report with Review of Literature
Authors: Deshpande Gauri , Arora Amandeep , Katdare Aparna , Prakash Gagan , Joshi Amit , Murthy Vedang , Desai Sangeeta , Menon Santosh 
Published: February 2025

AbstractAnaplastic lymphoma kinase (ALK) rearranged renal cell carcinoma (RCC) is a newly recognized entity in the 2022 WHO classification under molecularly defined renal tumors. It is imperative to diagnose this entity, especially with the advent of ALK-directed therapy. Herein, we report the case of a 52-year-old lady who presented with incidentally detected mass in the mid-pole of the left kidney. The patient underwent left radical nephrectomy. Microscopically, the tumor showed varied patterns, namely, papillary, tubulocystic, solid, and varied cell morphologies—cuboidal cells with low-grade nuclei, and rhabdoid cells in nests and clusters. Locoregional spread to the lymph nodes was noted. The tumor was reported as “renal cell carcinoma, unclassified.” On further immunohistochemistry, the tumor was diffusely positive for ALK by immunohistochemistry. Further, the finding of ALK rearrangement was confirmed by fluorescence in situ hybridization, thus confirming the diagnosis of ALK-rearranged RCC. She came back with progression after a year and was started on ALK-directed therapy after confirmation of ALK rearrangement. However, she succumbed to the disease 15 months after diagnosis. ALK-directed therapy has revolutionized the management of ALK-positive lung adenocarcinomas. Although ALK-rearranged RCC is a rare subtype of RCC, it is essential to know this case histopathologically for an accurate diagnosis and future development of targeted therapy.
Imbalance in spatiotemporal analysis of narcotics-related activities: a bibliometric review
Authors: Tajuddin Razik Ridzuan Mohd , Ismail Noriszura , Kamaluddin Mohammad Rahim , Nordin Ahmad Azwan Amin , Firdaus-Raih Mohd 
Published: February 2025

Abstract
The mapping of specific narcotics-related activities and determination of hotspots using spatiotemporal techniques enable the relevant law enforcement agencies to allocate more resources around hotspots rather than diluting manpower to canvas larger areas to conduct anti-narcotics operations. Since the use of spatiotemporal techniques to map narcotics-related activities is practiced globally, it is important to determine how often the techniques have been a core aspect of research methodology in investigating narcotics-related activities. This question can be answered by investigating how impactful the work documented in publications have been to the community by analyzing the following – descriptive summary, distributions of documents, authors’ productivity, core sources of publications, relevant affiliations, top cited documents, collaborations between countries and disproportion in selecting subjects for studies. In this paper, a bibliometric analysis of 323 documents in the Scopus database is investigated, in which the analysis revealed a 6.28% annual growth rate for the subject publications of which the majority are articles written in English. We further identified 20 “core” sources with one article which was cited a total of 691 times. Our analysis also revealed trends that provided insights into future research directions such as mapping the HIV infection caused by substance misuse as well studying the demography of the offenders. Our study also uncovered a gap that neglects the mapping of substance misuse crime in African countries that although not unexpected, presents a stark disparity in allocated resources. Our findings can be a starting point for strategizing future studies that integrate spatiotemporal analysis to address the increasing complexity of narcotics crimes with the expanding use of new psychoactive substances and the intertwining of substances misuse with public health issues.
Mapping AI ethics narratives: evidence from Twitter discourse between 2015 and 2022
Authors: Wei Mengyi , Zhang Puzhen , Chen Chuan , Chen Dongsheng , Zuo Chenyu , Meng Liqiu 
Published: February 2025

Abstract
The ethical issues that arise in the development of AI technologies are closely linked to public engagement. Although Twitter, as an online public sphere, provides a platform for exploring AI ethics discourse, it is difficult for current research to effectively extract fine-grained but meaningful information from the vast amount of social media data. To address this challenge, this paper proposes a research framework for the fine-grained exploration of AI ethics discourse on Twitter. The framework consists of two main parts: (1) combining neural networks with large-scale language models to construct a hierarchically structured topic framework that not only extracts popular topics of public interest, but also highlights smaller, yet significant voices; (2) using narrative metaphors to achieve the integration of fragmented information across levels and topics, ultimately presenting a complete story to help the public better understand the evolution of topics within AI ethics discourse. Our research has revealed that the most significant concern in the current AI ethics discourse is the lag in AI-related laws and ethical guidelines. It also shows that the integration of AI technology with the humanities is essential to promote a good public society. Through cross-level fine-grained mining, this study uncovers information hidden beneath the noise interference, which helps policymakers make targeted adjustments or improvements to policies. In addition, this research framework provides a reference for fine-grained mining of other specific issues in social media data.
Building sustainable information systems and transformer models on demand
Authors: Asselborn Thomas , Melzer Sylvia , Schiff Simon , Bender Magnus , Marwitz Florian Andreas , Aljoumani Said , Thiemann Stefan , Hirschler Konrad , Möller Ralf 
Published: February 2025

Abstract
The growing practice of archiving research data in repositories reflects an upward trend. However, storing data in an RDR (Research Data Repository) does not guarantee that the archived data will always be readily reusable, even if this fulfils the FAIR (Findable, Accessible, Interoperable Reusable) principles. To ensure sustainable RDM (Research Data Management), archiving must consider the future potential for data reuse in a low-threshold fashion. In this article, we demonstrate the utilisation of straightforward methods to implement a so-called warm or hot archiving for research data within an RDR, as opposed to the conventional cold archiving approach. We explore the additional value of using research data in the humanities, emphasising the advantages of maintaining data accessibility and relevance over time. In the humanities, evaluating numerous data sets efficiently is crucial for current and future projects. Reviewing and evaluating relevance is important, particularly when dealing with a substantial number of data sets. Rapid evaluation facilitates profound decisions on the utility of the data for one’s ongoing or upcoming projects. For hot archiving, this means that in addition to the research data, the data should be available in a human-friendly way, i.e., a viewer application to visualise the data should be easily accessible. However, as rapid developments in the IT sector mean that after a few years, it cannot be guaranteed that these viewers or other tools will work, we also show how data can be viewed in a user-specific way via the RDR and how sustainable viewing can be integrated into the RDR. This article presents a generic approach to building sustainable viewers, which we call information systems, or transformer models on demand using data from pre-modern Arabic. In addition, we show that the easy-to-use chatbot ChatGPT can alternatively be context-specifically prepared to deliver more precise results and associated resources in the field of humanities. On the one hand, we have achieved a substantial reduction in the development time of an information system, from months to seconds, as well as the ability to fine-tune BERT (Bidirectional Encoder Representations from Transformers) models without specific knowledge in selecting models or tools. On the other hand, we have developed a chatbot that not only provides project-specific responses but also references the sources.
Stokes/anti-Stokes Raman spectroscopy of Al0.86Ga0.14N semiconductor alloy
Authors: Lin Yuru , Li Yu , Wu Binbin , Liu Jingyi , Guo Ruiang , Wang Yangbin , Hu QiWei , Lei Li 
Published: February 2025

Abstract
The lattice dynamics of high Al composition semiconductor alloy, Al0.86Ga0.14N, in comparison with the intrinsic GaN and AlN are studied by Stokes/anti-Stokes Raman spectroscopy in the temperature range of 85~823 K. The phonon anharmonic effect in Al0.86Ga0.14N is found to be stronger than GaN, revealing the low thermal conductivity in the semiconductor alloy. The multi-phonon coupling behavior are analyzed by both the Stokes Raman and anti-Stokes Raman spectroscopy. It is interesting to find that the anti-Stokes scattering exhibits stronger three-phonon coupling behavior as compared to the Stokes scattering, which may be due to the fact that the anti-stokes scattering process is generated from excited state and the scattered photons have higher energies. The Stokes/anti-Stokes temperature correction factor β for Raman modes in Al0.86Ga0.14N alloy are all smaller than those of the corresponding intrinsic modes in GaN and AlN. The reasons for the difference in β can be attributed to three aspects, including the equipment setups, materials properties (the binding energy), and the coupling strength of Raman scattering and sample.
Evaluation of a hazardous drug surface contamination surveillance program in a large community hospital
Authors: Hayes-Porter Alexis , Shay Blake 
Published: February 2025

Abstract

Disclaimer
In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time.

Purpose
Risks of occupational exposures to hazardous drugs (HDs) have been documented and identified as needing to be monitored. To decrease potential exposures in a community hospital, this project evaluated the impact of implementing a hazardous drug wipe sampling technology (BD HD Check system; BD, Franklin Lakes, NJ) and accompanying environmental procedures, risk level scoring assessment, and recordkeeping tools on identifying HD surface contamination.

Methods
The 16-week evaluation focused on HD wipe sampling of locations (25 sites) within a cleanroom suite and infusion areas at the largest hospital of a multihospital community health system. Sites were determined through a risk stratification assessment to which areas were given a high, medium, or low-risk category to determine frequency of testing. HD wipe samples were tested for methotrexate, doxorubicin, and cyclophosphamide. Standard operating procedures (SOPs) were developed to address testing, decontamination, and retesting procedures.

Results
A total of 238 samples were collected over 16-weeks across 25 sample sites. Fifteen of 25 sites resulted in at least 1 positive, totaling 37 initially positive results. Following initial positives, 92.5% of sites successfully tested negative following decontamination. Three sites that remained positive after decontamination underwent a corrective and preventative action (CAPA) analysis and were negative after a second round of decontamination.

Conclusion
Sampling led to reduction in contamination and more transparency in HD monitoring. The HD wipe sampling technology (BD HD Check system) and accompanying procedures were shown to be helpful in establishing and refining SOPs for HD preparation, cleaning/decontamination, and wipe sampling.
Mixed mating system and intraspecific variation in lizard pollination of Withania frutescens (L.) Pauquy
Authors: Muñoz-Gallego Raquel , Traveset Anna , Beltrán Rafel , Hervías-Parejo Sandra 
Published: February 2025

Abstract

Premise of the study
Plant reproductive strategies are particularly relevant on islands, where environmental constraints usually shape ecological dynamics. In this sense, the role of lizards (Lacertilia) as flower visitors and potential pollinators has been increasingly recognized. However, lizards may also consume plant reproductive tissues, potentially influenced by lizard intraspecific traits such as age and sex. This study aims to investigate, for the first time, the reproductive biology of the rare Mediterranean shrub Withania frutescens (L.) Pauquy (Solanaceae), and to assess the role of the Balearic lizard Podarcis lilfordi Günther (Lacertidae) as a potential pollinator on Na Redona islet (Cabrera archipelago, Balearic Islands).

Methods
We analyzed flower traits (corolla length, corolla diameter, stamen length, and pistil length) and performed flower bagging experiments with three pollination treatments (open pollination, autogamy, and cross hand-pollination) from 2018 to 2021 to unravel the plant reproductive system. Fruit set, the number of seeds per fruit, seed weight, size and viability were then assessed. Observational censuses were conducted to identify the main flower visitors and estimate their visitation frequency. Finally, we measured morphometric traits of lizards and explored potential intraspecific variation in floral use.

Key results
The flowers of W. frutescens were morphologically hermaphroditic but functionally dioecious, spatially separated in unisexual individual plants. Open pollination and autogamy treatments resulted in similar fruit set, while cross hand-pollination produced the highest value. However, open pollination significantly increased seed weight and viability. Lizards were the most frequent floral visitors, accounting for 68% of visits, while insects made up the remaining 32%. Lizards played a dual role as both pollinators and florivores, with 45% of their visits potentially contributing to pollination and 55% involving florivory. Juveniles and females primarily conducted legitimate visits, whereas males –with a larger size- were more likely to consume the flowers.

Conclusions
Our research describes, for the first time, a mixed reproductive system in W. frutescens, combining hermaphroditism with cryptic dioecy. We also provide a new example of a lizard-pollinated plant, highlighting the importance of vertebrates on island pollination as well as the influence of pollinator intraspecific variation on plant reproductive success. Further research on the reproductive and pollination systems of small, isolated plant populations is crucial, given their heightened vulnerability to disturbance and genetic inbreeding.
Artificial induction of the UPR by Tet-off system-dependent expression of Hac1 and its application in Saccharomyces cerevisiae cells
Authors: Ishiwata-Kimata Yuki , Monguchi Masaki , Geronimo Ralph Allen Capistrano , Sugimoto Maya , Kimata Yukio 
Published: February 2025

Abstract
In response to endoplasmic reticulum (ER) stress, yeast Saccharomyces cerevisiae cells produce Hac1, which is a transcription factor responsible for the unfolded protein response (UPR). When Hac1 is unregulatedly expressed from a constitutive promoter, the ER is artificially enforced and enlarged, even without ER stress stimuli. However, such cells are unsuitable for applicative bioproduction because they grow quite slowly and quickly lose their high-UPR phenotype upon their long-term storage. To avoid this problem, we constructed S. cerevisiae plasmids for Hac1 expression under the control of the inducible Tet-off promoter. Yeast cells carrying these plasmids did not exhibit a considerable UPR and grew rapidly when the Tet-off promoter was repressed by doxycycline. In contrast, under the Tet-off inducing condition, these plasmids caused UPR induction, growth retardation, and ER expansion, depending on the copy number of the plasmid. Moreover, as expected, lipidic molecule production was increased under these conditions.
Oregano leaf odor regulates sodium chloride consumption in mice
Authors: Osada Kazumi , Akiyama Nanako , Hosono Akira , Ohata Motoko , Yokoyama Issei , Miyazono Sadaharu , Komai Michio 
Published: February 2025

Abstract
This study explores how the odor of oregano and its active component, carvacrol, influence salt preference in mice. Using a two-bottle choice test (distilled water vs. 0.15 M NaCl), 66 C57BL/6 J mice were exposed to oregano odor. Female mice showed a significant reduction in saline intake with oregano or carvacrol exposure, while the effect was lower in males. Carvacrol was identified in dried oregano using GC–MS with HS–SPME. Neurologically, oregano odor increased c-Fos immunoreactivity in the ventral bed nucleus of the stria terminalis (BNST), a region regulating salt appetite. These results suggest that oregano odor decreases salt preference, partly due to carvacrol, which stimulates brain areas controlling salt appetite. This present study highlights the role of olfactory cues in modulating dietary behavior and suggests potential applications for managing salt consumption in health contexts.