bluuebunny/crossref_metadata_2025_split huggingface dataset:
Randomized, Multicenter, Phase II Study of CO-101 Versus Gemcitabine in Patients With Metastatic Pancreatic Ductal Adenocarcinoma: Including a Prospective Evaluation of the Role of hENT1 in Gemcitabine or CO-101 Sensitivity
Authors: Poplin Elizabeth , Wasan Harpreet , Rolfe Lindsey , Raponi Mitch , Ikdahl Tone , Bondarenko Ihor , Davidenko Irina , Bondar Volodymyr , Garin August , Boeck Stefan , Ormanns Steffen , Heinemann Volker , Bassi Claudio , Evans T.R. Jeffrey , Andersson Roland , Hahn Hejin , Picozzi Vince , Dicker Adam , Mann Elaina , Voong Cynthia , Kaur Paramjit , Isaacson Jeff , Allen Andrew 
Published: November 2013

Purpose Gemcitabine requires transporter proteins to cross cell membranes. Low expression of human equilibrative nucleoside transporter-1 (hENT1) may result in gemcitabine resistance in pancreatic ductal adenocarcinoma (PDAC). CO-101, a lipid-drug conjugate of gemcitabine, was rationally designed to enter cells independently of hENT1. We conducted a randomized controlled trial to determine whether CO-101 improved survival versus gemcitabine in patients with metastatic PDAC (mPDAC) with low hENT1. The study also tested the hypothesis that gemcitabine is more active in patients with mPDAC tumors with high versus low hENT1 expression. Patients and Methods Patients were randomly assigned to CO-101 or gemcitabine, after providing a metastasis sample for blinded hENT1 assessment. An immunohistochemistry test measuring tumor hENT1 was developed. To dichotomize the population, an hENT1 cutoff value was defined using primary PDAC samples from an adjuvant trial, and a high/low cutoff was applied. The primary end point was overall survival (OS) in the low hENT1 subgroup. Results Of 367 patients enrolled, hENT1 status was measured in 358 patients (97.5%). Two hundred thirty-two (64.8%) of 358 patients were hENT1 low. There was no difference in OS between treatments in the low hENT1 subgroup or overall, with hazard ratios (HRs) of 0.994 (95% CI, 0.746 to 1.326) and 1.072 (95% CI, 0.856 to 1.344), respectively. The toxicity profiles in both arms were similar. Within the gemcitabine arm, there was no difference in survival between the high and low hENT1 subgroups (HR, 1.147; 95% CI, 0.809 to 1.626). Conclusion CO-101 is not superior to gemcitabine in patients with mPDAC and low tumor hENT1. Metastasis hENT1 expression did not predict gemcitabine outcome.
Solvent-induced Controllable Self-assembly of Poly(9,9-dihexylfluorene)
Authors: Xiao Xueqing , Bai Weibin , Cai Lifang , Lin Jinhuo 
Published: November 2013

Abstract
The microspheres, nanowires, and butterfly-like structures of poly(9,9-dihexylfluorene) were fabricated by a novel approach, namely, the nonsolvent vapor method (NSVM). The controlled formation of the micro- and nanostructures was well discussed, and the assembly model was proposed. A superhydrophobic film with butterfly-like structures was obtained. The NSVM was found to be useful in forming organic optoelectronic devices that were less sensitive to water. This led to a simple, rapid, and novel method for the formation of π-conjugated polymers without further functionalization.
Sensuous interfaces – Dancing Anima in Aotearoa New Zealand
Authors: East Ali 
Published: November 2013

Abstract
Sondra Fraleigh has described the body as bounded by skin and having form, yet merging, relational and metamorphic (Fraleigh 2012). In this article I draw on the making of a short four-minute film Anima (2005), co-directed by myself and videographer John Irwin, in order to discuss the ways that the intuitive sensuous soma may be presented in film. The purpose of the film was to explore ecological notions of perception, to engage the viewer in ‘relational seeing’ (Sewell 1999) and to lead the eye downwards and inwards in order that the viewer might perceive human skin and rock, seaweed and hair, land, ocean and body as the same yet distinct, separate and merging. At the same time, what is revealed in the film by the solo female dancer is the soma, whole and articulate, part of the ecology of place, and ‘place’ itself.
Estimating the ice thickness of mountain glaciers with a shape optimization algorithm using surface topography and mass-balance
Authors: Michel Laurent , Picasso Marco , Farinotti Daniel , Bauder Andreas , Funk Martin , Blatter Heinz 
Published: November 2013

Abstract
We present a shape optimization algorithm to estimate the ice thickness distribution within a two-dimensional, non-sliding mountain glacier, given a transient surface geometry and a mass-balance distribution. The approach is based on the minimization of the surface topography misfit at the end of the glacier's evolution in the shallow ice approximation of ice flow. Neither filtering of the surface topography where its gradient vanishes nor interpolation of the basal shear stress is involved. Novelty of the presented shape optimization algorithm is the use of surface topography and mass-balance only within a time-dependent Lagrangian approach for moving-boundary glaciers. On real-world inspired geometries, it is shown to produce estimations of even better quality in smaller time than the recently proposed steady and transient inverse methods. A sensitivity analysis completes the study and evinces the method's higher susceptibility to perturbations in the surface topography than in surface mass-balance or rate factor.
Ranging behavior and habitat use of the Assamese macaque (Macaca assamensis) in limestone habitats of Nonggang, China
Authors: Zhou Qihai , Wei Hua , Huang Zhonghao , Krzton Ali , Huang Chengming 
Published: November 2013

AbstractRanging behavior and habitat utilization are important indicators of ecological influences on individual behavior. We collected data on the ranging behavior and habitat use of two groups of Assamese macaques (
Implementation and analysis of an adaptive multilevel Monte Carlo algorithm
Authors: Hoel Håkon , von Schwerin Erik , Szepessy Anders , Tempone Raúl 
Published: November 2013

Abstract.
We present an adaptive multilevel Monte Carlo (MLMC) method for
weak approximations of solutions to Itô stochastic
differential equations (SDE). The work [Oper. Res. 56 (2008), 607–617]
proposed and analyzed an MLMC method based on a hierarchy of uniform time
discretizations and control variates to reduce the computational
effort required by a single level Euler–Maruyama Monte
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This work improves the adaptive MLMC algorithms presented
in [Lect. Notes Comput. Sci. Eng. 82, Springer-Verlag, Berlin (2012), 217–234]
and it also provides mathematical analysis of the improved algorithms.
In particular, we show that under some assumptions our
adaptive MLMC algorithms are asymptotically accurate and
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Global Facilitation of Attended Features Is Obligatory and Restricts Divided Attention
Authors: Andersen Søren K. , Hillyard Steven A. , Müller Matthias M. 
Published: November 2013

In many common situations such as driving an automobile it is advantageous to attend concurrently to events at different locations (e.g., the car in front, the pedestrian to the side). While spatial attention can be divided effectively between separate locations, studies investigating attention to nonspatial features have often reported a “global effect”, whereby items having the attended feature may be preferentially processed throughout the entire visual field. These findings suggest that spatial and feature-based attention may at times act in direct opposition: spatially divided foci of attention cannot be truly independent if feature attention is spatially global and thereby affects all foci equally.In two experiments, human observers attended concurrently to one of two overlapping fields of dots of different colors presented in both the left and right visual fields. When the same color or two different colors were attended on the two sides, deviant targets were detected accurately, and visual-cortical potentials elicited by attended dots were enhanced. However, when the attended color on one side matched the ignored color on the opposite side, attentional modulation of cortical potentials was abolished. This loss of feature selectivity could be attributed to enhanced processing of unattended items that shared the color of the attended items in the opposite field. Thus, while it is possible to attend to two different colors at the same time, this ability is fundamentally constrained by spatially global feature enhancement in early visual-cortical areas, which is obligatory and persists even when it explicitly conflicts with task demands.
Slidequake Generation versus Viscous Creep at Softrock-landslides: Synopsis of Three Different Scenarios at Slumgullion Landslide, Heumoes Slope, and Super-Sauze Mudslide
Authors: Walter Marco , Gomberg Joan , Schulz William , Bodin Paul , Joswig Manfred 
Published: November 2013

In this study, we describe conditions for slidequake generation at three different creeping softrock landslides: the Slumgullion landslide in the San Juan Mountains, Colorado, U.S., the Heumoes slope in the Austrian Alps, and the mudslide in Super-Sauze, French Alps. From a geomorphologic point of view, all three landslides are classified as creeping landslides with average velocities between centimeters to meters per year. Associating creep with viscous flow, and considering the largely saturated, clayey consistency of the slope body, one would not expect any brittle behavior. Thus, it came as a surprise that impulsive seismic signals indicative of shear fracture could be discovered by sensitive passive monitoring methods at all three slopes. These fracture signals occur in episodes, have similar signatures as small earthquakes, and could be located within the slide bodies, i.e., are evidence of slidequakes.Our investigations identified seismic and aseismic slip in each slide, with slidequakes focusing at significant bedrock structures or at lateral boundaries. Synoptic comparison of three scenarios underlines the importance of landslide-bedrock and landslide-lateral boundary interactions under gravitational loading and Mohr-Coulomb-type failure. Comparison to frictional and asperity models of crustal- and plate-scale boundaries may pave the way to a comprehensive understanding of slidequake generation, and future slope failure prediction.
Planning collaborative learning in virtual environments
Authors: Hernández-Sellés Nuria , González-Sanmamed Mercedes , Muñoz-Carril Pablo-César 
Published: November 2013

Collaborative learning has a strong presence in technology-supported education and, as a result, practices being developed in the form of Computer Supported Collaborative Learning (CSCL) are more and more common. Planning seems to be one of the critical issues when elaborating CSCL proposals, which necessarily take into account technological resources, methodology and group configuration as a means to boost exchange and learning in the community. The purpose of this study is to analyze the relevance of the CSCL planning phase and weigh up the significance of its key design components as well as examining group agreement typology and its usefulness in team building and performance. To do so, research was carried out using a non-experimental quantitative methodology consisting of a questionnaire answered by 106 undergraduate students from 5 different CSCL-based subjects. Results prove the usefulness of the planning components and the drafting of group agreements and their influence on group building and interaction. In order to ensure the quality of learning, it is essential to plan CSCL initiatives properly and understand that organizational, pedagogical and technological decisions should converge around a single goal which is to sustain the cognitive and social aspects that configure individual and group learning.
El trabajo colaborativo es una de las presencias dominantes en la formación apoyada en tecnologías, de ahí la importancia de las prácticas que se están desarrollando bajo las siglas CSCL (Computer Supported Collaborative Learning). Entre los aspectos que parecen ser determinantes para elaborar propuestas de CSCL se encuentra la planificación, que debe contemplar tanto los recursos tecnológicos como la metodología y la propia configuración de los grupos de trabajo con el fin de favorecer los intercambios y el aprendizaje en comunidad. El propósito de este estudio es analizar la importancia de la fase de planificación del CSCL, estimando el alcance de los componentes clave de su diseño, y examinando la tipología y utilidad de los acuerdos grupales en la creación y funcionamiento de los equipos. Para ello se llevó a cabo una investigación con una metodología cuantitativa de carácter no experimental de tipo encuesta en la que participaron 106 estudiantes de grado de cinco asignaturas que implementaron CSCL. Los resultados ponen de manifiesto la utilidad de los componentes de la planificación, así como la importancia de la redacción de acuerdos grupales y su incidencia en la creación y funcionamiento del grupo. Resulta esencial planificar adecuadamente el CSCL para garantizar el aprendizaje y entender que las decisiones organizativas, pedagógicas y tecnológicas deberían confluir en el objetivo de sustentar tanto los aspectos cognitivos como sociales que configuran el aprendizaje individual y grupal.
ICT in collaborative learning in the classrooms of Primary and Secondary Education
Authors: García-Valcárcel-Muñoz-Repiso Ana , Basilotta-Gómez-Pablos Verónica , López-García Camino 
Published: November 2013

Digital technologies offer new opportunities for learning in an increasingly connected society, in which learning to work with others and collaborate has become an extremely important skill. This article presents the results of a research study into the conceptions and practices of working teachers regarding collaborative learning methodologies mediated by information and communication technologies (ICT) in Elementary and Secondary Education schools. We analyze data concerning ICT contributions to collaborative work processes in the classroom, from the point of view of teachers at schools accredited with a high level of ICT by the Regional Government of Castile and Leon. We furthermore take into account the limitations of these tools, as well as teachers’ conceptions of collaborative learning strategies. The methodology is based on the content analysis of interviews of teachers from a representative sample of schools. The results indicate that teachers think that ICT have great potential for enhancing collaborative activities among students and for developing highly relevant generic skills, although they are also aware of the difficulties that both students and teachers face in educational practice.Las tecnologías digitales ofrecen nuevas oportunidades para el aprendizaje en una sociedad cada vez más conectada, en la cual aprender a trabajar con otros y colaborar se convierte en una competencia trascendental. El texto presenta resultados de una investigación sobre concepciones y prácticas del profesorado en ejercicio acerca de las metodologías de aprendizaje colaborativo mediadas por las tecnologías de la comunicación (TIC), en centros de enseñanza de Educación Primaria y Secundaria. En el artículo se analizan los datos referidos a las aportaciones de las TIC para llevar a cabo procesos de trabajo colaborativo en el aula, desde el punto de vista de los docentes de los centros acreditados con alto nivel TIC por la Junta de Castilla y León. También se expondrán las limitaciones que imponen estas herramientas, así como las concepciones docentes sobre las estrategias de aprendizaje colaborativo. La metodología se basa en el análisis de contenido de entrevistas realizadas a equipos docentes de una muestra representativa de centros educativos. Los resultados apuntan que en estos centros los docentes atribuyen a las TIC una alta potencialidad para enriquecer las actividades de trabajo colaborativo entre los estudiantes y conseguir el desarrollo de competencias transversales de gran relevancia, aunque son conscientes de las dificultades a las que tanto alumnos como profesores se enfrentan en la práctica educativa.
Researching on and with young people: Collaborating and educating
Authors: Domingo-Coscollola María , Sánchez-Valero Joan-Anton , Sancho-Gil Juana-María 
Published: November 2013

This paper reports on collaborative research on and with young people. In this study five groups of students in the final year of their Compulsory Secondary Education (CSE) from five different schools developed five ethnographic studies about how they communicate, express themselves and learn inside and outside school, with the support and collaboration of teachers and members of our research group. The paper begins by discussing the dimensions of collaboration in education, taking into account the contribution of collaborative and cooperative learning, and the potential of digital resources, situating earlier influences and characterizing the work realised. Then there is a description of the research carried out on and with the young people we invited to perform as investigators. The results focus on the description and conceptualization of the different types of collaboration that have emerged while carrying out the ethnographic studies in each of the schools using digital technologies. Finally, we discuss the implications and limitations of the work as a contribution to anyone interested in researching on and with young people, collaborating, educating and using digital resources.
Este artículo da cuenta de una investigación colaborativa realizada con y sobre los jóvenes. En este trabajo, cinco grupos de estudiantes de cuarto de Educación Secundaria Obligatoria (ESO), de otros tantos centros de Cataluña, han realizado cinco estudios etnográficos de forma colaborativa entre ellos, algunos de sus docentes y miembros de nuestro equipo de investigación, con la finalidad de explorar cómo y con qué los jóvenes se comunican, expresan y aprenden dentro y fuera de las instituciones educativas. Comienza discutiendo las dimensiones de la colaboración en la educación, teniendo en cuenta las aportaciones del aprendizaje colaborativo y cooperativo y las potencialidades de los recursos digitales, y situando los antecedentes y las particularidades del trabajo llevado a cabo. Sigue con la caracterización de cómo y en qué ha consistido la investigación con los jóvenes a los que invitamos a ejercer como investigadores. Los resultados se centran en la descripción y conceptualización de las formas de colaboración a las que ha dado lugar la producción de estos cinco estudios etnográficos en cada uno de los centros utilizando tecnologías digitales. Finalmente, se discuten las implicaciones del trabajo realizado y se señalan sus limitaciones lo que se configura como la principal aportación para quienes se propongan investigar con y sobre los jóvenes colaborando, educando y utilizando recursos digitales.
Digital media in Ecuador: Future perspectives
Authors: Punín-Larrea María-Isabel , Martínez-Haro Alison-Catherine , Rencoret-Quezada Nathalie-Angélica 
Published: November 2013

The advances in technology, especially in the field of communication, cause mass media to constantly evolve- and thus not to perish. Indeed, this occurs in situations that are marked by a series of media transformations and changes that have affected journalism as a profession and mass media as a process. The studies that have resulted from these changes have been positive and negative. This paper analyses the digital media panorama in Ecuador, the characteristics of journalism culture and the specific usage of web content. It describes the trends of the main digital media in the country, which have been selected for a case study. The article takes as a core reference ‘ten digital trends in media communication’ proposed by Cerezo-Gilarranz – a specialist in digital strategies. We then focus on the deficiencies of Ecuadorian mass media, which is mainly due to a lack of control over technological environments and the scarcity of links between business and journalism projects that have technological and innovative support, such as the usage of social networks and others. The final result is a detailed guide to the weaknesses and strengths of each digital medium that has been studied. Furthermore, this work highlights reliable trends so that the selected media can orientate towards digital environments. This is achieved by making use of technological tools for creating business and service opportunities.
El avance de la tecnología, en especial, en el ámbito de la comunicación, obliga a los medios a evolucionar constantemente para no morir en un escenario marcado por una serie de transformaciones y cambios mediáticos que han afectado al periodismo como profesión y a los medios de comunicación, proceso que ha generado estudios de todo orden. Este trabajo analiza el panorama mediático digital en Ecuador, las características de cultura periodística y el consumo de contenidos en la Red. Describe las tendencias de los principales medios digitales en el país, seleccionados para realizar un estudio de caso. El artículo toma como referencia central el estudio de las diez tendencias digitales en medios de comunicación de Cerezo-Gilarranz, especialista en estrategias digitales. Posteriormente se identifican las deficiencias que tienen los medios en Ecuador; principalmente por la falta de domino de los entornos tecnológicos y la escasa vinculación del proyecto empresarial y periodístico con soportes tecnológicos e innovadores, como el uso de redes sociales... El resultado final es una guía detallada de las debilidades y las fortalezas de cada medio digital en estudio. Asimismo, este trabajo propone tendencias fiables para que los medios estudiados puedan encaminarse firmes en entornos digitales, asumiendo a las herramientas tecnológicas como oportunidad de negocio y de servicio.
Les dimensions du rêve
Authors: Agnel Aimé 
Published: November 2013

À partir d’une émission scientifique d’Igor Barrère et Étienne Lalou diffusée à la télévision en 1976 – un long entretien sur le rêve avec Élie Humbert –, l’auteur expose la conception originale de cet analyste. Élie Humbert note tout d’abord la singularité des images oniriques : chaque rêveur a son vocabulaire propre. Le rêve, par ailleurs, n’est pas un objet, mais une expérience, un « vécu ». Aussi, son sens est-il à rechercher, non pas dans ses éléments pris séparément, mais dans son déroulement et sa dynamique. L’interprétation est dépendante du temps du rêve. Le moment où il survient est « essentiel à l’information ». On doit aussi tenir compte du fait qu’il conjoint paradoxalement mémoire et anticipation, passé et futur. Le rêve, conclut Élie Humbert, nourrit notre perplexité, car il établit « un rapport avec ce qu’on ne peut pas nommer, qui est le mouvement de la vie ».