bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of matrix metalloproteinase, myeloperoxidase, and oxidative damage in mesenteric ischemia–reperfusion injury
Authors: Kocael A , Inal BB , Guntas G , Kelten C , Inal H , Topac HI , Kocael P , Simsek O , Karaca G , Salihoglu Z , Uzun H 
Published: October 2015

Background: In this study, we investigated the alterations of matrix metalloproteinase (MMP) and tissue inhibitors of metalloproteinases (TIMPs), acute inflammation, and oxidative damage in the circulatory system and the intestine in response to mesenteric ischemia/reperfusion (I/R). Methods: Twenty-one rats were divided randomly into the following three groups ( n = 7 in each group): a sham group (CG), an ischemic group (IG), and an I/R group (I/RG). MMP-9, TIMP-1, and myeloperoxidase (MPO) were measured using the enzyme-linked immunosorbent assay method, and lipid peroxidation (quantified as thiobarbituric acid reactive substances (TBARS) content), ischemia-modified albumin, the prooxidant–antioxidant balance (PAB), and ferric-reducing antioxidant power (FRAP) were measured spectrophotometrically. The degree of intestinal injury was evaluated according to the Chiu scoring system. Results: A significant difference between the mean serum TIMP-1 and MMP-9 levels and the alanine transaminase activity was found among the groups. Compared with the I/RG group a significant difference in the mean tissue MMP-9, MPO, and TBARS levels in addition to the PAB and FRAP was found between the CG and IG groups. The level of MMP-9 also demonstrated a strong, positive, and valid correlation with the TBA-RS levels. A significant morphological change was observed in both the IG and the I/RG groups. The degree of intestinal injury was more severe in the I/R group and was characterized by either villous denudation or villous loss. Conclusions: These results suggest that MMP-9, TIMP-1, MPO, and oxidative stress may be important in the intestinal injury development that is induced by acute mesenteric I/R in a rat model. MMP-9 overexpression may increase the extent of intestinal villous loss, particularly when MMP-9 is upregulated by the TBARS present in the intestinal injury.
Vitamin D Status in an Elective Orthopedic Surgical Population
Authors: Michelson James D. , Charlson Mark D. 
Published: October 2015

Background: Adequate vitamin D availability is required for normal bone metabolism. Hypovitaminosis D is highly prevalent in latitudes above 30 degrees. The goal of this prospective study was to determine the prevalence of hypovitaminosis D in an unselected population of patients undergoing major ankle or hindfoot arthrodesis in Burlington, Vermont (latitude 44.5° N). Methods One hundred eighteen patients undergoing a major ankle, hindfoot, or midfoot arthrodesis between May 2012 and February 2014 were eligible for the study, of which 81 participated. All clinical data, including comorbidities, demographics, and lab values, were obtained from the comprehensive electronic medical record system that encompassed all inpatient and outpatient care. Based on the recommendations published by the Vitamin D Task Force Committee of the Endocrine Society, vitamin D levels above 30 ng/mL were considered normal. Statistical analyses were performed using a significance level of P <.05. Results Of 81 patients tested, 54 (67%) had low serum vitamin D. Older patients had lower risk for hypovitaminosis D (RR = 0.953, CI = 0.908, 0.999, P = .046), whereas a Charlson Index ≥3 had increased risk (RR = 16.8, CI = 1.5, 192.3, P = .023). Of the 16 patients retested after vitamin supplementation, only 9 (56%) corrected to normal. Conclusions: In an unselected population in Vermont undergoing hindfoot and ankle arthrodesis, there was a high prevalence of hypovitaminosis D, even in patients without predisposing risk factors. Consequently, routine testing or presumptive high-dose vitamin D replenishment therapy should be considered for all patients scheduled for such surgery, primarily to promote adequate skeletal calcium metabolism. Level of Evidence: Level II, prospective study.
Compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media
Authors: Sarakbi Iman , Krämer Irene 
Published: October 2015

Purpose The aim of this study was to determine the compatibility of epirubicin-loaded DC bead™ with different non-ionic contrast media over a period of seven days when stored light protected under refrigerated conditions. Methods DC bead™ (2 ml) (Biocompatibles UK Ltd) of the bead size 70–150 µm ( = DC bead M1) or bead size 100–300 µm were loaded with 75 mg epirubicin powder formulation (Farmorubicin® dissolved in 3 ml water for injection to a concentration of 25 mg/ml) or 76 mg epirubicin injection solution (Epimedac® 2 mg/ml) within 2 h or 6 h, respectively. After removal of the excess solution, the epirubicin-loaded beads were mixed in polypropylene syringes with an equal volume (∼1.5 ml) of contrast media, i.e. Accupaque™ 300 (Nycomed Inc.), Imeron® 300 (Bracco S.p.A), Ultravist® 300 (Bayer Pharma AG), Visipaque™ 320 (GE Healthcare) and agitated in a controlled manner to get a homogenous suspension. Syringes with loaded beads in contrast media were stored protected from light under refrigeration (2–8℃). Compatibility was determined by measuring epirubicin concentrations in the suspensions in triplicate on day 0, 1, and 7. A reversed phase high-performance liquid chromatography assay with ultraviolet detection was utilized to analyze the concentration and purity of epirubicin. Results Mixing of epirubicin-loaded beads with different non-ionic contrast media released 0.1–0.5% of epirubicin over a period of 24 h, irrespectively, of the DC bead™ size or type of contrast media. No further elution or degradation was observed after seven days when the admixtures were stored protected from light under refrigeration. Conclusion Compatibility of epirubicin-loaded DC bead™ with an equal volume of different contrast media in polypropylene syringes is given over a period of seven days. Due to a maximum elution of 0.1–0.5% of epirubicin from loaded DC bead™, admixtures with contrast media can be prepared in advance in centralized cytotoxic preparation units. Microbiological aspects have to be considered when determining the expiration date of the product.
Once Daily Self-Monitoring of Blood Glucose (SMBG) Improves Glycemic Control in Oral Hypoglycemic Agents (OHA)–Treated Diabetes
Authors: Harashima Shin-ichi , Nishimura Akiko , Ikeda Kaori , Wang Yu , Liu Yanyan , Inagaki Nobuya 
Published: October 2015

Background: The aim of this study was to compare glycemic control between SMBG-continued and -discontinued subjects with type 2 diabetes in the SMBG-OHA study. Method: Of the 96 subjects from the SMBG-OHA study, 59 were recruited for the 24-week, comparison follow-up study. The study outcomes were the differences in change in HbA1c levels at 24 weeks between the 2 groups, and change in SMBG frequency in SMBG-continued subjects. Results: Although health insurance does not cover the cost of SMBG, 22.0% of subjects continued SMBG of their own will after the SMBG-OHA study was completed. HbA1c levels were maintained from 6.81 ± 0.55% to 6.64 ± 0.53% in SMBG-continued subjects. Conversely, HbA1c levels were increased from 7.18 ± 0.63% to 7.48 ± 0.84% in SMBG-discontinued subjects. HbA1c levels were significantly different by 0.83 ± 0.25% (95% CI: −1.33 to −0.36). The difference in change in HbA1c between the groups was −0.46% (95% CI: −0.78 to −0.15). SMBG frequency was decreased from 2.02 ± 1.06 to 1.53 ± 0.86 times a day. Conclusions: HbA1c levels were maintained in SMBG-continued subjects but increased in SMBG-discontinued subjects. The study implied that almost once daily SMBG is helpful to maintain glycemic control in non-insulin-treated type 2 diabetes.
Topical use of Matricaria recutita L (Chamomile) Oil in the Treatment of Monosymptomatic Enuresis in Children
Authors: Sharifi Hosein , Minaie Mohammad Bagher , Qasemzadeh Mohammad Javad , Ataei Nematollah , Gharehbeglou Mohammad , Heydari Mojtaba 
Published: October 2015

Aim. To evaluate the efficacy of topical use of Matricaria recutita L oil in the treatment of enuresis in children. Methods. Eighty patients diagnosed as monosymptomatic nocturnal or daytime enuresis were allocated to receive Matricaria recutita L (chamomile) oil or placebo topically for 6 weeks in a double-blind randomized placebo-controlled trial with a parallel design. Patients were evaluated prior to and following 8 weeks of the intervention in terms of frequency of enuresis and any observed adverse events. Results. The mean frequency of enuresis at the first, second, and third 2 weeks was lower in the intervention group compared with the placebo group, and the differences were statistically significant ( P < .001, P = .03, and P < .001, respectively). There was no report of any adverse event in the study groups. Conclusion. The findings of this study showed that the topical use of (chamomile) oil can decrease the frequency of nocturia in children with monosymptomatic nocturnal or daytime enuresis.
Surgical Management of Recurrent Musculotendinous Hamstring Injury in Professional Athletes
Authors: Sonnery-Cottet Bertrand , Daggett Matt , Gardon Roland , Pupim Barbara , Clechet Julien , Thaunat Mathieu 
Published: October 2015

Background: Hamstring injury is the most common muscular lesion in athletes. The conservative treatment is well described, and surgical management is often indicated for proximal tendinous avulsions. To our knowledge, no surgical treatment has been proposed for failure of conservative treatment in musculotendinous hamstring lesions. Purpose: To describe the surgical management of proximal and distal hamstring musculotendinous junction lesions in professional athletes after failure of conservative treatment. Study Design: Case series; Level of evidence, 4. Methods: A consecutive series of 10 professional athletes, including 4 soccer players, 4 rugby players, and 2 handball players, underwent surgical intervention between October 2010 and June 2014 for the treatment of recurrent musculotendinous hamstring injuries. All athletes had failed at least 3 months of conservative treatment for a recurrent musculotendinous hamstring injury. Surgical resection of the musculotendinous scar tissue was performed using a longitudinal muscular suture. Lower Extremity Functional Scale (LEFS) and Marx scores were obtained at the 3-month follow-up, and a final phone interview was completed to determine recurrence of hamstring injury and return to previous level of play. Results: The mean age at surgery was 25.2 years (range, 19-35 years). The musculotendinous hamstring lesions involved 8 semitendinosus and 2 biceps femoris, with 6 injuries located proximally and 4 distally. Conservative treatment lasted a mean 5.1 months (range, 3-9 months) after last recurrence, and the patients had an average of 2.7 (range, 2-5) separate incidents of injury recurrence before surgical intervention was decided upon. At the 3-month follow-up, all patients had Marx activity scores of 16 and LEFS scores of 80. All 10 patients returned to the same level of play at a mean 3.4 months (range, 2-5 months). At a mean follow-up of 28.7 months, none of the athletes had suffered a recurrence. No surgical complication was encountered. Conclusion: In cases of failed conservative treatment of musculotendinous hamstring lesions, surgical intervention may be a viable treatment option in professional athletes and allows the patient to return to the same level of play.
Performance assessment of fragrance finished cotton with cyclodextrin assisted anchoring hosts
Authors: Khanna Shelly , Sharma Swati , Chakraborty J. N. 
Published: October 2015

AbstractInfusion of textiles with aromatic essential oils makes them immense value enriched for the aesthetic dominated fashion
consumers to attain cosmeto-therapeutic and medicinal benefits. However, longevity of aroma on the textile with the time passage and subsequent launderings is a major concern for researchers and consumers too. In this work, essential oils of Eucalyptus, Peppermint, Lavender, Jasmine, Clove and Cedarwood were applied directly on cotton as well as with anchoring hosts as cyclodextrin in native and modified form viz. monochlorotriazine-β-cyclodextrin (MCT-βCD) to assess their stability of retention on the fabric surface. The release rate of oils, in isolation, had revealed the disappearance of fragrances rapidly with time as a result of weak physical forces between essential oils and textile surfaces in the absence of any anchoring hosts. MCT-β-CD showed enhanced fragrance stability with added advantage of exhibiting no major change in tensile strength, stiffness and air permeability of cotton.
Both ciliary and non-ciliary functions of Foxj1a confer Wnt/β-catenin signaling in zebrafish left-right patterning
Authors: Zhu Ping , Xu Xiaolei , Lin Xueying 
Published: October 2015

ABSTRACT
The Wnt/β-catenin pathway is implicated in left-right (LR) axis determination; however, the underlying mechanism remains elusive. Prompted by our recent discovery that Wnt signaling regulates ciliogenesis in the zebrafish Kupffer's vesicle (KV) via Foxj1a, a ciliogenic transcription factor, we decided to elucidate functions of Foxj1a in Wnt-regulated LR pattern formation. We showed that targeted injection of wnt8a mRNA into a single cell at the 128-cell stage is sufficient to induce ectopic foxj1a expression and ectopic cilia. By interrogating the transcription circuit of foxj1a regulation, we found that both Lef1 and Tcf7 bind to a consensus element in the foxj1a promoter region. Depletion of Lef1 and Tcf7 inhibits foxj1a transcription in the dorsal forerunner cells, downregulates cilia length and number in KV, and randomizes LR asymmetry. Targeted overexpression of a constitutively active form of Lef1 also induced an ectopic protrusion that contains ectopic transcripts for sox17, foxj1a, and charon, and ectopic monocilia. Further genetic studies using this ectopic expression platform revealed two distinct functions of Foxj1a; mediating Wnt-governed monocilia length elongation as well as charon transcription. The novel Foxj1a-charon regulation is conserved in KV, and importantly, it is independent of the canonical role of Foxj1a in the biosynthesis of motile cilia. Together with the known function of motile cilia movement in generating asymmetric expression of charon, our data put forward a hypothesis that Foxj1a confers both ciliary and non-ciliary functions of Wnt signaling, which converge on charon to regulate LR pattern formation.
High Removal Efficiency and Regeneration Property of Formaldehyde Capture by Ti4+-based Porous Coordination Polymer
Authors: Mito-oka Yasuko , Sawada Yuki , Masumori Tadao , Horike Satoshi , Kitagawa Hiroshi , Kitagawa Susumu 
Published: October 2015

Abstract
The formaldehyde capture process is investigated by a titanium ion (Ti4+)-based porous coordination polymer (PCP), MIL-125-NH2. This framework contains aromatic amino groups on the pore surface, which effectively capture formaldehyde. The removal efficiency and regeneration properties of MIL-125-NH2 are better than the conventional amine-impregnated activated carbon, and the material does not degrade even after &gt;140 adsorption/desorption cycles.
The foundation of the Melbourne Code Appendices: Announcing a new paradigm for tracking nomenclatural decisions
Authors: Wiersema John H. , McNeill John , Turland Nicholas J. , Orli Sylvia S. , Wagner Warren L. 
Published: October 2015

AbstractA newly expanded digital resource exists for tracking decisions on all nomenclature proposals potentially contributing to Appendices II–VIII of the International Code of Nomenclature for algae, fungi, and plants. This system owes its origins to the Smithsonian Institution's “Proposals and Disposals” website created by Dan H. Nicolson to track conservation/rejection proposals, but now also treats proposals to suppress works or requests for binding decisions. The new resource was created to accommodate the steadily expanding content of the Appendices in relation to the main body of the Code. A database is now available to generate these Appendices, as has been done for the Melbourne Code. A web interface allows users to query database content in various ways to review proposal histories or to extract all or part of the Appendices. An analysis of the underlying data was conducted to make comparisons between proposals submitted for the various editions of the Code. These include the type of nomenclatural remedy sought, the major group concerned, the numbers of names involved, the timeliness of the proposal evaluation process, the proposal success rate, and the diversity of proposal authorship. The success of proposals was also evaluated by the type of remedy sought and by major groups.
Typification of Linnaean names in the genus Vitis (Vitaceae)
Authors: Iamonico Duilio , Galasso Gabriele , Banfi Enrico , Ardenghi Nicola M.G. 
Published: October 2015

AbstractThe typification of the Linnaean names Vitis laciniosa and V. vinifera var. apyrena is discussed. The names are lecto‐ and neotypified, respectively, using specimens from LINN.
Philyrophyllum (Asteraceae) transferred from Gnaphalieae to Athroismeae based on phylogenetic analysis of nuclear and plastid DNA sequence data
Authors: Bentley Joanne , Klaassen Esmerialda S. , Bergh Nicola G. 
Published: October 2015

AbstractThe small southern African genus Philyrophyllum (Asteraceae) has traditionally been placed amongst the basal lineages of tribe Gnaphalieae, close to the Namibian‐centred genus Pentatrichia. However, a recent plastid phylogeny placed Philyrophyllum distant from Pentatrichia within the Gnaphalieae crown radiation, a finding that is strongly contradicted by a suite of morphological synapormorphies that are otherwise unvarying within the crown radiation. In the present study, two linked nuclear loci (ITS, ETS) and one plastid region (trnL‐trnF) are sequenced to determine the phylogenetic position of Philyrophyllum, with the addition of available plastid psbA‐trnH spacer and ndhF sequences for outgroup taxa. Maximum likelihood bootstrap and Bayesian analysis is used to assess support for phylogenetic relationships. Individual plastid and nuclear, as well as combined data, strongly support a close relationship between Philyrophyllum and the African‐centred, morphologically diverse genus Anisopappus, currently placed in subtribe Anisopappinae of the anomalous tribal assemblage Athroismeae. Athroismeae is the sister group of Feddeeae and the “Heliantheae tribal alliance”, a large mainly northern hemisphere grouping that is phylogenetically distant from Gnaphalieae.
Top-down, bottom-up, or both?: Successful structures and processes in youth radio training projects
Authors: Huesca Robert 
Published: October 2015

Abstract
Beginning in the early 1990s, radio training projects aimed at teaching young people (aged 15 – early 20s) the basics of audio production began emerging throughout the United States. By decade’s end, these ‘youth radio’ training programmes mushroomed to about 40 different places across the country due to the availability of grants from individuals, foundations and state agencies with a variety of agendas. Despite more than a decade of experience, youth radio training programmes have received some journalistic attention, but little to no scholarly analysis. This article responds to this lack of scholarship of this robust area of media practice by examining the experiences of participants at four well-established, yet structurally diverse youth radio training programmes. Making sense of these experiences can be accomplished from multiple theoretical perspectives including media literacy, feminist criticism, cultural studies, etc. For the purposes of this research, however, theoretical contributions from alternative and community media and development communication will be used. The remainder of this article will review the alternative, community, and development communication literature in terms of the conceptual framework and the research questions that guided this study. It will then identify the research settings and methods of data collection and analysis. The bulk of the article, however, will present the findings from the research before turning to a summary discussion and conclusions section.
Radio documentary production as cognitive mapping in sound: The making of La Frontera
Authors: McNaughton Colm 
Published: October 2015

Abstract
In response to the depthlessness and fragmentation of postmodern experience, Marxist literary critic Fredric Jameson offers the anticipatory and utopian concept of cognitive mapping. Cognitive mapping holds out the promise for radical social transformation, in times when such possibilities can seem remote. One of the limitations of Jameson’s articulation of cognitive mapping is that he does not offer a viable practice of cognitive mapping. The making of the radio documentary, La Frontera: A journey into the borderlands of Mexico and the United States, is an experiment in cognitive mapping in sound, grounded in an emergent practice: the art of listening. To draw out and explain the thinking and practices that constitute the making of La Frontera, I examine the pre-production, production and post-production phases in turn. To conclude I draw out the implications of this experiment for the field of radio studies.
Doing radio in the age of Facebook
Authors: Bonini Tiziano 
Published: October 2015

Abstract
This article begins with the hypothesis that social media are the prosecution of radio by other means; its aim will be to focus on the changes that radio has undergone since it started to mix with social media, in particular Facebook (FB). How deeply have such changes affected the relationship between radio producers and listeners? The article will analyse the cases of three Italian radio programmes that have developed an intense interaction with their listeners through FB. It will report on quantitative observation of the social media activity of these programmes over an entire week and show the different social media strategies implemented by the selected programmes, as well as their different dramaturgical relations with the listeners.
Radio formats and social media use in Europe – 28 case studies of public service practice
Authors: Bonini Tiziano , Fesneau Elvina , Perez J. Ignacio Gallego , Luthje Corinna , Jedrzejewski Stanislaw , Pedroia Albino , Rohn Ulrike , Sellas Toni , Starkey Guy , Stiernstedt Fredrik 
Published: October 2015

Abstract
The aim of this article is to report, summarize and spread the results of a largescale European research project funded by EBU Radio in 2011 to map best practices in social media and European public radio, focusing on the way successful public service radio formats have incorporated social media in their production flow. The programmes have been selected for one of the following reasons: programmes that are audience leaders in their country, use innovative radio language or are youthoriented productions. The survey has been carried out by a team of ten European researchers from seven countries on a sample of 28 public radio programmes analysed for two months between January and February 2011. The research team attempted to answer the empirical question: ‘How social media are used by public service?’. Are there some common threads and shared practices among successful programmes in different countries? The team adopted an empirical approach based on social media content analysis and interviews with radio producers. This article will present the main results of this empirical research project. It will conclude with practical guidelines for public radio production and social media innovation.