bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh budaya organisasi, kepemimpinan melayani terhadap kinerja dosen di Institut Agama Kristen Negeri Tarutung
Authors: Purba Enricho Fiktorando , Simaremare Aman , Lubis Zuraida 
Published: July 2024

<p>Penelitian ini bertujuan menguji apakah budaya organisasi, kepemimpinan melayani berpengaruh signfikan terhadap kinerja dosen. Penelitian ini menggunakan pendekatan kuantitatif dengan analisis regresi berganda. Data diperoleh dengan menyebarkan angket <em>google form online</em> yang diisi oleh dosen secara sukarela yang terdiri beberapa strata pendidikan, masa kerja dan jabatan fungsional. Dengan jumlah sampel 32 orang yang dengan teknik <em>stratified purposive sampling. </em>Kemudian, data diolah secara deskriptif kuantitatif untuk melihat kecenderungan hasil setiap variabel. Selanjutnya, hasil data diolah menggunakan analisis regresi berganda dengan aplikasi <em>SPPS 22</em>. Hasil analisis deskriptif menunjukkan bahwa kinerja dosen di IAKN Tarutung masuk ke dalam kategori kinerja yang tinggi. Akan tetapi, hasil penelitian ini menunjukkan bahwa budaya organisasi dan kepemimpinan melayani tidak memiliki pengaruh yang signifikan terhadap hasil kinerja dosen yang tinggi tersebut. Artinya, budaya organisasi dan kepemimpinan melayani yang ada di IAKN Tarutung tidak serta merta menunjang kinerja dosen. Oleh karena itu, perlu penelitian lebih lanjut terkait variabel lain yang lebih signifikan untuk menunjang kinerja dosen.</p><p> </p><p><strong><em>The Influence of organizational culture, servant leadership on the performance of lecturers at Tarutung State Institute of Christianity</em></strong></p><p> </p><p><em>This study aims to test whether organizational culture and service leadership have a significant effect on lecturer performance. This study uses a quantitative approach with multiple regression analysis. Data was obtained by distributing online Google form questionnaires filled out by voluntary lecturers consisting of several educational strata, tenure, and functional positions. With a total sample of 32 people using a stratified purposive sampling technique. Then, the data is processed descriptively quantitatively to see the tendency of the results of each variable. Furthermore, the data results were processed using multiple regression analysis with the SPPS 22 application. The results of the descriptive analysis show that the performance of lecturers at IAKN Tarutung falls into the high-performance category. However, the results of this study indicate that organizational culture and servant leadership do not have a significant influence on the results of the high performance of lecturers. This means that the organizational culture and servant leadership that exist in IAKN Tarutung do not necessarily support the performance of lecturers. Therefore, further research is needed related to other variables that are more significant to support lecturer performance.</em></p>
Preoperative Laboratory Values Predicting Periprosthetic Joint Infection in Morbidly Obese Patients Undergoing Total Hip or Knee Arthroplasty
Authors: Telang Sagar , Mayfield Cory K. , Palmer Ryan , Liu Kevin C. , Wier Julian , Hong Kurt , Lieberman Jay R. , Heckmann Nathanael D. 
Published: June 2024

Background:
Morbidly obese patients are an ever-growing high-risk population undergoing total hip arthroplasty (THA) and total knee arthroplasty (TKA) for end-stage osteoarthritis. This study sought to identify preoperative laboratory values that may serve as predictors of periprosthetic joint infection (PJI) in morbidly obese patients undergoing THA or TKA.

Methods:
All morbidly obese patients with preoperative laboratory data before undergoing primary elective TKA or THA were identified using the Premier Healthcare Database. Patients who developed PJI within 90 days after surgery were compared with patients without PJI. Laboratory value thresholds were defined by clinical guidelines or primary literature. Univariate and multivariable regression analyses were utilized to assess the association between PJI and preoperative laboratory values, including total lymphocyte count, neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), monocyte-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), albumin level, platelet count, albumin-globulin ratio, hemoglobin level, and hemoglobin A1c.

Results:
Of the 6,780 patients identified (TKA: 76.67%; THA: 23.33%), 47 (0.69%) developed PJI within 90 days after surgery. The rate of PJI was 1.69% for patients with a hemoglobin level of <12 g/dL (for females) or <13 g/dL (for males), 2.14% for those with a platelet count of <142,000/µL or >417,000/µL, 1.11% for those with an NLR of >3.31, 1.69% for those with a PLR of >182.3, and 1.05% for those with an SII of >776.2. After accounting for potential confounding factors, we observed an association between PJI and an abnormal preoperative NLR (adjusted odds ratio [aOR]: 2.38, 95% confidence interval [CI]: 1.04 to 5.44, p = 0.039), PLR (aOR: 4.86, 95% CI: 2.15 to 10.95, p < 0.001), SII (aOR: 2.44, 95% CI: 1.09 to 5.44, p = 0.029), platelet count (aOR: 3.50, 95% CI: 1.11 to 10.99, p = 0.032), and hemoglobin level (aOR: 2.62, 95% CI: 1.06 to 6.50, p = 0.038).

Conclusions:
This study identified preoperative anemia, abnormal platelet count, and elevated NLR, PLR, and SII to be associated with an increased risk of PJI among patients with a body mass index of ≥40 kg/m2. These findings may help surgeons risk-stratify this high-risk patient population.

Level of Evidence:
Prognostic Level III. See Instructions for Authors for a complete description of levels of evidence.
Wave Mechanics of Microwave Absorption in Films: Part 3 – Multilayered Films
Authors: Liu Yue , Liu Ying , Drew Michael 
Published: June 2024

Abstract

In the field of microwave absorption, the quarter-wavelength theory (QWM) is commonly
employed to describe the properties of films with multiple layers. However, this study
demonstrates the inadequacy of QWM as therein conventional results pertaining to single
layered films with or without a metal backing are typically applied to the intermediate layers
of multilayer films, but this approach is flawed, as it overlooks the presence of incident
microwaves on both sides of the intermediate layer, focusing solely on those in front of the
film. To address this notable omission, our work introduces a novel theoretical framework
suitable for multilayer films
Integrated biological and chemical control of Fusarium wilt by Bacillus velezensis EB1 and potassium sorbate
Authors: Liu Siwen , Yang Wenlong , Yang Xiaofang , Gong Ronggao , Xiang Dandan , Li Chunyu 
Published: June 2024

Abstract

Banana wilt caused by Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) is a globally distributed soilborne disease that poses a serious threat to banana production. Many different control measures have been implemented but have not proven effective enough. Here, a combined strategy of Fusarium wilt control involving the recognized biological agent B. velezensis EB1 and the bioactive compound potassium sorbate was evaluated. Our results showed that potassium sorbate inhibited Foc TR4 in a dose-dependent manner. Potassium sorbate did not affect the growth of EB1 in vitro; instead, it promoted its growth and antagonistic ability by upregulating the expression of antagonistic genes. In greenhouse experiments, the combined application of EB1 and potassium sorbate significantly reduced the disease index of banana by suppressing fungal growth in roots while promoting plant growth. Overall, our results indicate that potassium sorbate combined with B. velezensis EB1 has strong potential for the sustainable management of banana Fusarium wilt.
Downregulation of Klebsiella pneumoniae RND efflux pump following indole signal produced by Escherichia coli
Authors: Salama Galila G. , El-Mahdy Taghrid S. , Moustafa Walaa H. , Emara Mohamed 
Published: June 2024

Abstract

Background
More than a century has passed since it was discovered that many bacteria produce indole, but research into the actual biological roles of this molecule is just now beginning. The influence of indole on bacterial virulence was extensively investigated in indole-producing bacteria like Escherichia coli. To gain a deeper comprehension of its functional role, this study investigated how indole at concentrations of 0.5-1.0 mM found in the supernatant of Escherichia coli stationary phase culture was able to alter the virulence of non-indole-producing bacteria, such as Pseudomonas aeruginosa, Proteus mirabilis,and Klebsiella pneumoniae, which are naturally exposed to indole in mixed infections with Escherichia coli.
Results
Biofilm formation, antimicrobial susceptibility, and efflux pump activity were the three phenotypic tests that were assessed. Indole was found to influence antibiotic susceptibly of Pseudomonas aeruginosa, Proteus mirabilis and Klebsiella pneumoniae to ciprofloxacin, imipenem, ceftriaxone, ceftazidime, and amikacin through significant reduction in MIC with fold change ranged from 4 to 16. Biofilm production was partially abrogated in both 32/45 Pseudomonas aeruginosa and all eight Proteus mirabilis, while induced biofilm production was observed in 30/40 Klebsiella pneumoniae. Moreover, acrAB and oqxAB, which encode four genes responsible for resistance-nodulation-division multidrug efflux pumps in five isolates of Klebsiella pneumoniae were investigated genotypically using quantitative real-time (qRT)-PCR. This revealed that all four genes exhibited reduced expression indicated by 2^−ΔΔCT < 1 in indole-treated isolates compared to control group.
Conclusion
The outcomes of qRT-PCR investigation of efflux pump expression have established a novel clear correlation of the molecular mechanism that lies beneath the influence of indole on bacterial antibiotic tolerance. This research provides novel perspectives on the various mechanisms and diverse biological functions of indole signaling and how it impacts the pathogenicity of non-indole-producing bacteria.
Choroidal vascularity index as potential biomarkers in chronic central serous chorioretinopathy with macular neovascularization
Authors: Song Yanping , Zhang Xianggui , Hui Yannian , Ming Yan , Huang Zhen , ye ya 
Published: June 2024

Abstract

Objective: To evaluate choroidal vascular index (CVI) in eyes with chronic central serous chorioretinopathy (cCSC) complicated with macular neovascularization (MNV) using ultra-widefield swept-source optical coherence tomography angiography.
Method: We retrospectively analyzed 50 eyes of 46 patients with MNV due to cCSC (W group) and 66 eyes of 52 cCSC patients without MNV (Wi group). A group of 67 eyes of 40 age-matched normal subjects were included for controls. The scan protocol included a vertical 20 mm × horizontal 24 mm area comprising 9 subfields. CVI were compared among each group.
Results: The average age in W group were significantly bigger than in Wi group (56.0±6.4 vs. 49.0±7.9, p < 0.001). Except for the superotemporal and temporal regions, the CVI was significantly lower in W group than in Wi group (all p < 0.05). The CVI of the central region in W, Wi, and normal groups were 35.66±3.31, 37.44±2.31, and 32.39±5.24, respectively (p < 0.001). Central CVI was correlated with subfoveal choroidal thickness (r = 0.674, p＜0.001) and W group (r = -0.304, p＜0.001).
Conclusions: Decreased CVI may represent a change in the vascular structure of the choroid in cCSC with MNV eyes, and these changes are not limited to the macular area. CVI can be a potential biomarker for cCSC with MNV eyes.
Influence of Roxolid Implant Material on The Implant Stability of Maxillary Implant Retained Overdenture
Authors: Ibrahim Amany , Eid Hany Ibrahim , Mohamed Shaimaa Lotfy , fadl sawsan maged 
Published: June 2024

Abstract

Background
Long-term success of implant restoration depends on many factors one of them is the sufficient implant stability which is lowered in compromised bone density sites such as the maxilla as it is categorized as type III & IV bone, so searching for a new innovation and updates in implant material and features is very mandatory. So, the aim of this study was to compare between two implant materials (roxolid and traditional titanium) on the primary and secondary stability of implant retained maxillary overdenture.
Methods
Eighteen completely edentulous patients were selected. All patients received maxillary implant-retained overdentures and lower complete dentures; patients were divided equally into two groups according to the type of implant materials. Group A received a total number of 36 implants made of roxolid material and Group B received a total number of 36 implants made of traditional titanium alloys. Implant stability was assessed using ostell device, the primary implant stability was measured at the day of implant installation however, secondary implant stability was measured after six weeks of implant placement. Paired t-test was used to compare between primary and secondary stability in the same group and an independent t-test was used to compare between the two groups with a significant level < 0.05.
Results
Independent t-test revealed a significant difference between the two groups with p -value = 0.0141 regarding primary stability and p-value < 0.001 regarding secondary stability, as roxolid implant group was statistically higher stability than titanium group in both. Paired t- test showed a statistically significant difference in roxolid implant group with p-value = 0.0122 however, there was non-statistically significant difference in titanium group with p-value = 0.636. Mann Whitney test showed a significant difference between the two groups regarding amount of change in stability with p value = 0.191. roxolid implant group showed a higher amount of change in stability than the titanium implant group.
Conclusion
Within the limitation of this study, it could be concluded that: Roxolid implants showed better primary and secondary stability than conventional titanium one in implant retained maxillary overdenture.
Trial registration:
NCT06334770 at 27-3-2024.
The “Overlooked” Entropy and the Associated Role of Phonons in the Mixing Stabilization for Complex Ceramics
Authors: Tang Xiaochuan , Weinberger Christopher , Thompson Gregory 
Published: June 2024

Abstract

The concept of high entropy materials has been introduced based on the idea that multiple principal components can be mixed through the increase in configurational entropy. Implicit in this idea is that the vibrational entropy, the other component of the mixing entropy, is small compared to the configurational entropy. To explore this relationship, we examined the mixing enthalpy, configurational entropy, and vibrational entropy of two binary ceramic systems - the transition metal carbides and transition metal diborides. We computed the vibrational entropy directly using the dynamical matrices obtained from density functional theory and the quasi-harmonic approximation. The mixing vibrational entropy of the mixed diborides are at least as large as the configurational entropy while it is smaller for the carbides. Utilizing the phonon density of states, we further demonstrate the origin of the high mixing vibrational entropy arises because of a large number of new low frequency modes that appear in the diborides. Similar modes occur in the carbides but occur at larger frequencies. This differences ultimately arise because of the structural differences where metal atoms share nearest neighbors in the diborides, while they do not in the carbides. This increased vibrational mixing entropy dramatically enhances the mixing of the diborides and demonstrates that this type of entropy cannot be neglected when considering what stabilizes mixtures and provides a new perspective on what is considered high entropy.
Psychological distress and influencing factors in lung cancer patients based on the stress system model: a cross-sectional study
Authors: Liu Yuxiu , Li Shuzhen , Wang Xin , Li Hua , Zhang Lan 
Published: July 2024

Abstract

Background
Lung cancer is one of the most prevalent causes of cancer-related mortality worldwide. Due to the low survival rate of patients with intermediate and advanced lung cancer, the challenging nature of treatment, the economic burden and the poor prognosis, most patients experience anxiety, fear and other psychological distress. If left untreated over a long period of time, these negative emotions will gradually develop into depression, anxiety or other serious mental illnesses. Furthermore, this can have a detrimental effect on the quality of life of the patient and the effectiveness of the treatment. Consequently, this study undertook a comprehensive investigation into the current status of psychological distress in patients with lung cancer and the factors that influence it. The findings provide a theoretical basis for clinical medical personnel to identify and implement timely, personalised psychological interventions.
Methods
Convenience sampling method was adopted to select lung cancer patients hospitalised in three hospitals in the country as the study subjects. General information questionnaire, psychological distress thermometer, cancer coping style questionnaire, brief illness perception questionnaire Edmonton Symptom Assessment Scale, and Perceived Social Support Scale were used to conduct the survey. SPSS 25.0 software was used to analyse the collected data; univariate, correlation analysis and binary logistic regression were used to analyse and screen the factors of psychological distress in lung cancer patients.
Results
435 lung cancer patients were finally included in this study. The results showed that the DT score was (4.24±2.356) and the prevalence of psychological distress was 52.87%. The results of binary logistic regression analysis showed that age, monthly family income, cancer coping styles, disease perception, symptoms and social support were the main correlates of psychological distress in lung cancer patients (P < 0.05).
Conclusions
As the detection rate of psychological distress in lung cancer patients is high, clinical staff should dynamically observe the psychological changes of lung cancer patients, do a good job in screening and stratified management of psychological distress, and provide personalised psychological guidance to establish a positive mindset, so as to reduce the negative emotions of patients,and to improve the quality of life of patients' health-related issues.
Resilient Roads in Challenging Terrain: A Case Study of Siddhartha Highway in Nepal
Authors: Chhetri Nishesh P. , Jaiswal Rishav , Poudel Rabina 
Published: June 2024

Abstract

Nepal is a country known for its diverse and challenging topography, and it relies heavily on a robust road infrastructure network to connect its remote regions and urban centers. This study addresses the critical need for enhanced road safety and infrastructure resilience on the Siddhababa road section of the Siddhartha Highway, Nepal, notorious for its high accident rates and susceptibility to landslides. Given the road's strategic importance in connecting remote regions and its challenging topographical conditions, our research aimed to identify the most suitable pavement type to mitigate these issues. Through a detailed examination incorporating eight different soil tests, alongside evaluations of traffic loads, weather conditions, and existing pavement performance, we adopted a comparative analysis methodology to assess the viability of flexible versus rigid pavements within this unique context. Results revealed that the soil composition and environmental conditions of the Siddhababa section significantly influence pavement performance, with specific gravity, moisture content, and California Bearing Ratio (CBR) tests indicating a nuanced suitability for both pavement types under varying circumstances. Our analysis concluded that, despite the economic and staged reinforcement benefits of flexible pavements, the durability, safety, and maintenance considerations favor the adoption of rigid pavement for the Siddhababa road section. However, acknowledging the economic constraints, a hybrid approach is recommended, emphasizing rigid pavements for the most vulnerable sections and flexible pavements elsewhere. This study contributes to the pavement engineering field by providing a model for pavement type selection in mountainous regions, aiming to enhance road safety and durability amidst challenging environmental conditions.
Dynamic Loading Effects on the Mechanical Behavior and Constitutive Damage Model of Foliated Slate
Authors: Ou Xuefeng , Xu Shiquan , Hu Qinxin , Tang Cong , Liao Wei , Tang Xiaolong 
Published: June 2024

Abstract

Understanding the anisotropic mechanical properties of rocks is crucial in rock engineering planning and execution. Layered structures, including foliation and bedding, introduce planes of weakness that profoundly affect the rock's mechanical response. This research aimed to examine the impact of foliation orientation, indicated by the dip angle (θ), and the strain rate (\(\dot {\varepsilon }\)) on the dynamic mechanical behaviour of the slate. To this end, dynamic compression tests were conducted on slate samples utilizing a split-Hopkinson pressure bar (SHPB). When the foliation is parallel to horizontal plane (θ = 0°), tensile mechanism dominates the failure mode. When the foliation planes take a dip angle to horizontal plane (θ = 30°, 45° and 60°), shear-sliding along foliation planes gradually dominated as the angle increased, resulting in shear-tensile failure. When the foliation planes are perpendicular to horizontal plane (θ = 90°), the sample primarily exhibits tensile splitting failure along foliation planes. Motivated by experimental results, we developed a constitutive model to characterize the damage process of foliated slate. The model assumes that the strength of microstructural units within foliated slate follows a Weibull distribution. To account for the effects of different dip angles and strain rates on the slate foliation planes' response, a dynamic loading viscous coefficient, η, is incorporated. The proposed model has precise physical meanings and proficiently illustrates the complete stress-strain process of the slate.
Fibrosis Impairs cGAS-Mediated Responses to Immunotherapy in Advanced HCC
Authors: Westover Ken , Sheng Jianpeng , Wang Lin , Song Jinyuan , Zhang Junlei , ZHOU ZHIWEI , Zhao Yaxing , Guo Chengxiang , Tang Jianghui , Ji Yongtao , Li Taohong , Yan Tianxing , Shao Wei , Bai Xueli , Li Qing , Liang Tingbo 
Published: June 2024

Abstract

Hepatocellular carcinoma (HCC) management is challenging due to its heterogeneous tumor microenvironment and poor treatment responses. To develop personalized approaches, we conducted a clinical trial of transarterial chemoembolization (TACE) combined with immune checkpoint blockade (ICB) where we collected tumor specimens for comprehensive multi-omic profiling. Treatment response was associated with increased infiltration of anti-tumor T cells, driven by cGAS-STING activation within immune-suppressive epithelial cells. However, fibrotic processes impaired these responses in some patients. Based on this insight, we conducted an animal trial in an HCC model where we added an anti-fibrotic agent to ICB and TACE mimic. This improved efficacy compared to ICB and TACE mimic alone. To identify patients who would benefit from such treatment, we constructed a predictive model using data from a limited immunohistochemistry panel and a group sparse learning algorithm. Our findings provide a blueprint for crafting personalized therapies for HCC and other cancers.