bluuebunny/crossref_metadata_2025_split huggingface dataset:
1840 – Pharmacokinetics Of Lithium During Delivery And In The Neonatal Period. a Preliminary Data
Authors: Guitart M. , Imaz M.L. , Soy D. , Torra M. , González-Rodríguez A. , Hernández S. , Hernández Rambla C. , Soler C. , Torres A. , Garcia-Esteve L. 
Published: July 2013

IntroductionLithium has been used in the treatment of bipolar disorder in pregnant women. However, information on the pharmacokinetics of lithium during perinatal period is scarce.ObjectivesTo study pharmacokinetics of lithium during delivery and in the neonatal period.MethodsA prospective, observational and naturalistic study was conducted at the PERINATAL PSYCHIATRY PROGRAM CLÍNIC-BARCELONA, from 2005 to 2012. We included all consecutive cases of pregnant women with bipolar disorder I or II (n = 22), and on maintenance treatment with lithium monotherapy (n = 13) or polytherapy (n = 9) during pregnancy who elected artificial feeding. Lithium plasma concentrations in maternal blood and umbilical cord were detected. Lithium plasma concentrations in infants (n = 16) at delivery and in the neonatal period were obtained to calculate elimination half-life, which was estimated by lineal regression. Technique: AVL 9180 electrolyte analyser using a lithium-selective electrode (detection limit =0.10 mEq/L).ResultsWomen did not fulfil diabetes criteria pre-pregnancy and during pregnancy. Attending to neonatal outcomes, infants exposed to polytherapy had a higher weight at birth (percentils) than those exposed to lithium alone [53.38 (33.40) vs. 70.22 (26.25)]. No statistically significant differences were found in umbilical cord:maternal plasma concentration ratio between those treated with lithium monotherapy and women treated with polytherapy (1.05 vs. 1.08). The lithium mean elimination half-life (SD) in infants was 6.73 (9.12) days.ConclusionsLithium crosses placental barrier almost completely. Elimination half-life in neonates exposed to lithium in utero was 6.73 days. Moreover, lithium treatment during pregnancy requires therapeutics monitoring in exposed dyads.
1841 – Increased Mortality In Young Women With Personality Disorder
Authors: Holm H. , Ekselius L. , Björkenstam E. , Björkenstam C. 
Published: July 2013

IntroductionYoung women with personality disorders (PD) are common in psychiatric inpatient care. The clinical impression is that there is a considerably increased incidence the last decade.Objectives and aimTo show changes in frequency and extent of inpatient care for PD, and the relation to suicide.MethodAll admissions for inpatient care given a primary diagnosis of PD in compulsory or voluntary care years 1990 to 2010 were extracted from the National Patient Register. Subsequently, data from the Cause of Death Register were extracted and linked for the same time period.ResultsThere were more than 60,000 admissions for PD in Sweden 1990–2010. During the last ten years there was a doubling of the number of yearly admissions for young women in the ages 18 to 24 years, and inpatient care hospitalization for PD are currently six times more common for women than for men in this age group. The same is true for compulsory care. Every fifth woman in this age group who had committed suicide had been treated for PD within the last five year period prior to the suicide.ConclusionsThe incidence of inpatient care in young women with PD did show a sharp rise during the last decade. There was a corresponding increase in suicide with a diagnosis of PD. Guidelines for treatment and care exist but more knowledge and action plans directed both to health care and the society are urgently needed.
1842 – Severe Mental Illness And Metabolic Syndrome: a Meta-analysis
Authors: Bartoli F. , Carrà G. , Carretta D. , Lax A. , Pini E. , Clerici M. 
Published: July 2013

IntroductionPeople suffering from Severe Mental Illness (SMI) have a shorter life expectancy than general population. The excess of mortality may be primarily due to premature cardiovascular diseases. Subjects with a diagnosis of SMI may have an high prevalence of Metabolic Syndrome (MetS).AimTo estimate the risk of MetS among subjects with SMI compared to their counterpart without SMI.MethodsA systematic review and meta-analysis of English and non-English articles using PubMed, Embase and PsycINFO was performed. ORs with related confidence intervals were used as association measures. All pooled analyses were based on random-effects models.ResultsThe pooled analysis showed a statistically significant association for MetS in people suffering from SMI. However, we found a consistent level of heterogeneity between the included studies. Subanalyses showed that both SCZ and BD had higher risk than general population without SMI. No statistical differences were found comparing SCZ and BD subjects.ConclusionsPeople with SMI have significantly higher risk to having MetS than general population. Despite some limitations, the results of present meta-analysis emphasize the relevance of a continuous cardio-metabolic assessment in the SMI population. Longitudinal researches are needed in order to assess the impact of a regular cardiovascular screening, prevention and treatment on the improvement of health status and life expectancy among people suffering from SMI.
1848 – From Gene Expression Variation To Definition Of Biomarkers In Depression
Authors: Belzeaux R. , Ibrahim E.C. 
Published: July 2013

Several studies examined gene expression variations in depressive patients compared to control subjects in post-mortem samples as well as in fresh peripheral tissues.Our aim has been investigate gene expression variations during Major Depressive Episode (MDE) in peripheral blood mononuclear cells (PBMCs). We collected PBMCs from two different cohorts of severe MDE patients (n=11 and n=13) and compared gene expression between patients and matched-control subjects. Moreover, in a 64 weeks prospective study, we had the opportunity to investigate what happens when a healthy subject gets his first MDE. We analysed gene expression variations accross time in both patients and controls and used both pan-genomic microarray and RT-qPCR strategies for RNA quantification. Finally, to compare gene expression variations in blood tissue and in post-mortem, we benefited from transcriptome databases to reanalyze, with uniform filtering and quantification procedures, gene expression in a large set of samples collected from other groups.We found several genes whose expression vary significantly between patient and control subjects as well as between the severe acute MDE phase and the following therapeutic response or remission phases occuring several weeks and months later, respectively. Beyond then, both well-known candidate genes, such as 5HTT, TPH1 or NRG1, and new genes (HIST1E1, PPT1) could be proposed for biomarkers development in MDE.Our results demonstrate that gene expression variation in PBMCs could be relevant as biomarkers for depression. The convergence of our data and other studies will be discussed as well as the comparability between brain and blood gene expression.
1857 – Peer Relationships And Adolescents Mental Health: Finding From The Seyle Project In Italy
Authors: Iosue M. , Carli V. , D’Aulerio M. , Basilico F. , Recchia L. , Apter A. , Balazs J. , Bobes J. , Brunner R. , Corcoran P. , Cosman D. , Durkee T. , Haring C. , Kahn J.P. , Keeley H. , Marusic D. , Postuvan V. , Resch F. , Saiz P. , Varnik A. , Varnik P. , Wasserman C. , Hoven C. , Sarchiapone M. , Wasserman D. 
Published: July 2013

IntroductionPeer relationships play a critical role in the development of adolescents, not only for the acquisition of social skills but also for the sense of personal identity and competence. Thus the quality of peer relationships influences actual and future mental health of the adolescent.ObjectivesSEYLE (Saving and Empowering Young Lives in Europe) is a randomized controlled trial, funded by the EU, evaluating interventions for mental health promotion and suicide prevention. The study comprised 12,395 high-school students from 11 European countries.AimsWe investigated the differences on psychological problems between students with poor and good peer relationships.Methods1,195 adolescents (mean age 15.3 ± 0.6; 68% females) from the Molise region constituted the Italian sample. Adolescents were identified as with poor peer relationships if they never or just sometimes get along with people of their age, feel that peers like having them in the group and feel that peers were kind and helpful. Psychometric measures were used to assess mental health problems such as depression (Beck Depression Inventory II), anxiety (Zung Self-Assessment Anxiety Scale), well-being (WHO-5) and suicidal ideation (Paykel Suicide Scale).ResultsAdolescents who reported poor peer relationships scored significantly higher (p < .005) on the scales assessing depression, anxiety and suicidal ideation and significantly lower (p < .001) on the WHO-5.ConclusionsParticularly in adolescence peer relationships may influence psychological well-being and vice versa mental health influences the openness to the others. So promoting mental health and contemporary improve social skills could lead adolescents to a better life.
1859 – The Effect Of Unemployment On Mental Health
Authors: Chletsos M. , Mazetas D. , Kotrotsiou E. , Gouva M. 
Published: July 2013

IntroductionConsidering the current Greek economic crisis, it is reasonable to discuss the potential and expected effects of the crisis in mental health.ObjectiveThis study examined the effect of unemployment on mental health.AimThis study aimed at detecting the interaction of unemployment on the bio-psycho-social health.Materials and methods273 community individuals participated in the present study (122 men - 151 women, mean age 49,2± 6,9). The measures used were: a) Family Environment Scale (FES), b) the Hostility and Direction of Hostility Questionnaire (HDHQ), c) the Symtom Checklist 90-R (SCL-90), and d) State - Trait Anxiety Inventory (STAI), e) Short Form Health Survey (SF-36), f) Other As Shamer Scale (OAS), g) Experience of Shame Scale (ESS).ResultsMultivariate analysis was applied for the statistical analysis of data, and the results was: a) the unemployed have the highest level (6.82) of feelings of inferiority, the total price (47.30) of internal shame, State Anxiety (47,58), Obsessive- Compulsive (11,42), interpersonal sensitivity (8,30), depression (13,64), phobic anxiety (3,79), and intropunitiveness hostility (7,45). Still have the lowest levels of the scales of Intellectual - Cultural Orientation (4,97), family orientation for active recreational activity (3,61), mental health (58,00), physical role (62,12) and summary scale of physical health (266,64).ConclusionIt was found that the unemployed suffer more than all social groups at periods of economic crisis and this has impacts on psychosomatic health, on state stress, as much as on the feelings of inferiority and shame which they feel.
1878 – The Relationship Between Life Satisfaction And Levels Of Social Functioning In Elderly
Authors: Senyurt M. , Gun H. , Demiralp M. 
Published: July 2013

PurposeThis descriptive study aims to determine the relationship between life satisfaction and levels of social functioning in elderly.MethodThe sample of the study is consisted of 115 individuals who lives in a district of Aydın between January-March 2012 and who are volunteer to participate the study. The data were obtained from Sociodemographic Data Collection Form, Social Functioning Scale (SFS) and the Life Satisfaction Scale (LSS). Chi-quare, Correlation, Mann-Whitney and Kruskal-Wallis tests were used in data analyzes.Findings57.4% of the participants were women, 58.3% of elderly participants were married and 93% used auxiliary device. The mean LS total score of men were higher than women (X=10.1 ±3.7). There was a statistically significant relationship between total score of Life Satisfaction Scale and the subscales of Social Functioning. A statistically significant difference were found between age and interpersonal functioning, independence-competence, independence-performance subscales of SFS (X2= 11.584, p= 0.003, X2= 14.988, p= 0.001 and X2= 20.190, p= 0.00 respectively).Unlike the male, life satisfaction scores were increased in females if leisure time activities were increased (z=3.445, p= 0.001). There was a positive correlation between interpersonal functionality and life satisfaction score (r= 0.188, p= 0.045) in elderly. Interpersonal functioning and business-professional scores were lower in the individulas who were using the auxiliary devices (respectively X2=12.405, p= 0.03 and X2=25.674, p= 0.00). The individuals who live alone were more socially withdrawn than the others (X2= 41 289, p = 0.00).ResultsLife satisfaction and social functioning in elderly were affected from each other in high levels.
1890 – Creative Agency: The Autobiography Of Mental Illness: An Exploratory Review Of Practice Of Writing As a Tool During Mental Illness
Authors: Kumar S. , Gent M. 
Published: July 2013

IntroductionMental Illness is a very unique and intimate experience. Over the ages various art forms, particularly writing have been used to document experiences of mental illness. Though the history of Psychiatry is a feature of mainstream Psychiatric training, complementary study of literature and its relevance to mental illness is underused.ObjectivesTo undertake an exploratory search of writing as tool to reflect the phenomenology of mental illness and to evaluate the role of medical humanities in understanding and coping mental illness.AimsTo present an explorative review of a selection of poems and prose by authors with mental illness who have written in English Language.MethodsWe conducted a comprehensive search of online databases including the Madness and Literature Network (UK), Medical Humanities Resource Database (UK), the Arts Literature and Medicine Database (US) and other popular books.ResultsWe compare various extracts by well known authors along with the lesser known contemporary accounts of writers to evaluate the role of writing.ConclusionsThere is a long tradition of writing about depression mental illness in the canon of English literature. Compared to autobiographical writing about depression, it is difficult to identify many autobiographical accounts of severe mental illness. Examples of writing projects illustrate that people with severe mental illness, and with dementia, may use the support of others to produce creative writing. It may be useful to Psychiatrists in training, and to wider society, to reflect on the creative agency inherent in their writing.
1901 – Child And Adolescent Psychiatry In Light Of National Programme Of Mental Health In Poland
Authors: Cialkowska-Kuzminska M. , Kasprzak M. , Kiejna A. 
Published: July 2013

IntroductionNational Programme of Mental Health was established by the government in 28.12.2010. It specifies direction of health care development. The main goals of National Programme of Mental Health are: 1. Promotion mental health and prevention of mental disorders 2. Provision of support and easy access to psychiatric health care and other forms of care necessary for living in families and society.3. Development of research and information about mental health. Nevertheless there is still lack of the separate, coherent programme on promoting and preventing mental health among children and adolescents.ObjectivesTo indicate the main barriers in current development of child and adolescent psychiatry in Poland.MethodsQuality and quantity assessment of national programmes, analyses of distribution of child and adolescent mental heath services.ResultsHowever a significant improvement in area of child and adolescent psychiatry took place, some barriers are still noticeable: the insufficient number of child and adolescents psychiatrists, low numbers of programmes related to early intervention, low availability of psychotherapy and sociotherapy, insufficient number of centres to help dysfunctional families and families in crises, low number of programmes on mental health promotion implemented as regular activities in schools.ConclusionsThere are needs of coordination in service planning and regular evaluation of child and adolescent mental heath services.
1905 – Are Psychiatrists And Neurologists Different In The Treatment Of Dementia?
Authors: Roberto A. , Guarda C. 
Published: July 2013

Introduction and objectivesDementia is a health problem that needs a careful diagnosis and treatment. The authors investigated the prescription habits of neurologists and psychiatrists in patients with dementia and analyzed the differences.MethodologyAn online questionnaire was sent to Portuguese psychiatrists and neurologists about the initial diagnosis and treatment in dementia.Results103 questionnaires were validated (46% psychiatrists). The Cholinesterase Inhibitors (IChE) were the most subscribed substances in both specialties, followed by memantine by neurologists (82%) and antipsychotics by psychiatrists (86%). The least prescribed drugs are benzodiazepines (7% : neurologists; 24%: psychiatrists) and nootropic drugs (8% in both). The combination of IChEs is more used by psychiatrists than neurologists, but the combination with memantine is similar in both. The majority does not associate nootropics (80%), but in those who do 77% are psychiatrists. In the treatment of depressive symptoms the majority uses Serotonin Uptake Inhibitors (79%). In sleep disorders 46% prescribe antidepressant and 31% antipsychotics. In the initial evaluation 94% of physicians request CT scan and blood work. Neuropsychological assessment is requested by 65% of psychiatrists and 44% of neurologists.Discussion/conclusionIn our sample the diagnostic and therapeutic approach in dementia is in accordance to the international guidelines. In some cases the initial investigation to exclude treatable dementias is not requested, which points to the importance to the professionals’ sensibilization. It is also interesting to discuss the differences of prescription between the two specialties, namely nootropics, benzodiazepines, antipsychotics and the association of two IChE.
1910 – Alcohol Related Disorders In a Psychiatric Unit In a Famous Wine-growing Area Of Romania. a 10 Years Retrospective Study
Authors: Sarpe M. , Prelipceanu D. , Ladea M. 
Published: July 2013

IntroductionAlcohol is the third leading risk factor for Europeans disease and mortality. Romania has one of the biggest alcohol consumption per capita. The county of Vrancea comprises around 100.000 people, and is a well known wine grapegrowing region.Objectives/aimsThe assessment of patients with psychiatric disorders related to alcohol consumption hospitalized in the Psychiatric Department of the Hospital of Vrancea, over a 10 year period.MethodsPatients with psychiatric disorders related to alcohol consumption hospitalized between 2002 and 2011 were analyzed in terms of socio-demographic variables: primary diagnosis at discharge, gender, age, residence, average number of hospitalization days. We used the computerized system of the hospital to evaluate those variables. For the primary diagnosis we have used the International Classification of Diseases (ICD-10).ResultsOf 13.738 patients hospitalized over the study period (10 years), 3.376 (24.57%) were admitted for psychiatric disorder related to alcohol consumption (compared to schizophrenia - 18.19%). The most frequent disorders were: alcohol induced withdrawal (F10.3) - about one third; alcohol induced delirium tremens (F10.4) - around 20% and alcohol induced acute intoxication (F10.0) - around 20%. The majority of the patients were men (87.02%) and most of them were from the rural area. The average number of hospitalization days was around 5.5. Most of the patients were between 35 and 45 years old.ConclusionsThe greater percentage of alcohol induced disorders in our psychiatric unit indicates that we have to increase our efforts to reduce the harmful use of alcoholl, its health and social consequences.
1932 – Pharmacotherapy Of Borderline Personality Disorder During The Time
Authors: Grambal A. , Grambalová Z. , Praško J.P. 
Published: July 2013

IntroductionIn patients suffering from borderline personality disorder (BPD) primarily psychotherapeutic care is indicated. Pharmacotherapy is considered as adjuvant and often controversial way of treatment.ObjectivesDemonstration of pharmacological approach to BPD patients in Olomouc Czech Republic and compare with treatment guidelines. treatment guidelines.AimsThe aim of our study was to compare treatment of BPD patients in 2007 and 2011MethodThe paper examines the state in 2007 and 2011 in BPD patients at the Department of Psychiatry, University Hospital. Our study included outpatients and inpatients treated in all departments. Inclusion criteria were diagnosis BPD. Medication was assessed according to the documentation at discharge or during outpatient care according to the transcript record.ResultsIn most cases are BPD patients treated according to current guidelines. The treatment consists of SSRI antidepressants, anticonvulsants and second-generation of antipsychotics. Problem can be considered in some cases with medication dosage, combination, administration of benzodiazepine anxiolytics, hypnotics.ConclusionBPD patients are treated according to current recommendations. Inpatients are more medicated than outpatients. The reason is probably in relation with the severity of the symptoms. Medication did not differ from the majority of best practices. But with a lack of strong evidence about its effect, it seems appropriate to move towards its reduction. Supported by the project IGA MZ CR NT 11047-4/2010
1938 – Actuality Of The Kretschmer's Sensitive Delusion Of Reference In The Dsm v Era: Two Case Reports
Authors: Widakowich C. , Van Wettere L. , Hubain P. , Snacken J. 
Published: July 2013

The sensitive delusion of reference has been coined by Kretschmer in 1919. This delusion reaction comports three levels:1)the sensitive character that is defined as shy, hyperemotives and sensitives subjects that are marked by a high sense of moral values, pride, a relational hyperesthesia resulting a high vulnerability in social contacts, and a tendency to self-criticism to internalize painfully failures and susceptibility.2)A traumatic event that reveals the subject its own failure and who humiliates him on the plan ethics.3)It follows then the delusion of reference itself with: depressive remorse with hypochondriac fears and thoughts of persecution on conversations of a great banality of everyday life.It settled in adults (usually after 35 years), ‘old singles’, or ‘young masturbators’. It is generally complicated with severe depressive episodes. Evolution is less often chronic than in the other paranoias, however, even after a favorable development, the signs are likely to reappear on the occasion of a new disappointment.The French Psychiatry school individualizes this syndrome within non-dissociative chronic delusions, among the paranoid delusions, hallucinatory chronic psychosis and paraphrenia. In DSM-IV, the sensitive delusion of reference is classified under delusional disorder category with all not dissociative chronic delusions. In the current conceptual reduction, we illustrate this fine entity by two clinical vignettes.