bluuebunny/crossref_metadata_2025_split huggingface dataset:
Open-Label, Multicenter, Phase I/II, First-in-Human Trial of TK216: A First-Generation EWS::FLI1 Fusion Protein Antagonist in Ewing Sarcoma
Authors: Meyers Paul A. , Federman Noah , Daw Najat , Anderson Peter. M. , Davis Lara E. , Kim AeRang , Macy Margaret E. , Pietrofeso Angela , Ratan Ravin , Riedel Richard F. , Trucco Matteo , Breitmeyer James B. , Toretsky Jeffrey A. , Ludwig Joseph A. 
Published: July 2024

PURPOSE
Ewing Sarcoma (ES), a rare cancer with a pathognomonic translocation resulting in the Ewing sarcoma gene (EWS)::FLI1 oncoprotein, has a poor prognosis in the relapsed/refractory (R/R) setting. Tokalas (TK)216 was designed to bind EWS::FLI1 proteins directly, disrupt protein-protein interactions, and inhibit transcription factor function. TK216 plus vincristine showed synergistic activity in preclinical tumor models. To our knowledge, we report the results of a first-in-class, first-in-human phase I/II trial of TK216 in R/R ES.

PATIENTS AND METHODS
TK216 was administered intravenously as a continuous infusion to patients with R/R ES in 11 cohorts. The dosing duration of 7 days was later extended to 10, 14, and 28 days. Vincristine could be added on day 1 after cycle 2, per investigators’ choice. The trial used a 3 + 3 design with an expansion cohort at the recommended phase II dose (RP2D).

RESULTS

A total of 85 patients with a median age of 27 years (range, 11-77) were enrolled. The maximum tolerated dose for the 14-day infusion of TK216, 200 mg/m
2
once daily, was determined in cohort 9 and selected as the RP2D. The median previous number of systemic therapies regimens was three (range, 1-10). The most frequent-related adverse events in patients treated at the RP2D included neutropenia (44.7%), anemia (29.4%), leukopenia (29.4%), febrile neutropenia (15.3%), thrombocytopenia (11.8%), and infections (17.6%). In cohorts 9 and 10, two patients had a complete response, one had a partial response, and 14 had stable disease; the 6-month progression-free survival was 11.9%. There were no responses among the eight patients in cohort 11.

CONCLUSION
TK216 administered as 14-day continuous infusion with or without vincristine was well tolerated and showed limited activity at the RP2D in R/R ES.
Dynamics of diseases spreading on networks in the forms of reaction-diffusion systems
Authors: Sun Gui-Quan , He Runzi , Hou Li-Feng , Gao Shupeng , Luo Xiaofeng , Liu Quanhui , Zhang Yicheng , Chang Lili 
Published: July 2024

Abstract
In the face of persistent threats posed by infectious diseases, despite remarkable medical advancements, understanding and efficiently controlling their spatial spread through mathematical modeling remain imperative. Networked reaction-diffusion systems offer a promising avenue to effectively delineate population discrete distribution and individual movement heterogeneity. However, the dynamics of spatial diseases within these systems and the formulation of optimal control strategies are currently undergoing vigorous development. In this letter, we illustrate the dynamics of spatial disease spread in networked reaction-diffusion systems through the lens of optimal control, considering various network complexities from pairwise networks to higher-order networks. It then emphasizes their applicability in designing effective spatial disease control strategies across diverse network complexities. Finally, we discuss the existing challenges.
Multichannel information transmission via a dual-frequency point space-time coding metasurface
Authors: He Xiaohang , Li Chenxia , Fang Bo , Tian Ying , Chen Liang , Hong Zhi , Jing Xufeng 
Published: July 2024

Space-time coding (STC) digital metasurfaces enable dynamic control of nonlinear harmonics. To achieve efficient frequency tuning and harmonic control, we propose a one-bit column-controlled temporal coding dual-frequency point STC digital metasurface. Using a field-programmable gate array (FPGA) to control diode switching, the metasurface is encoded to generate multiple target reflected harmonics as independent information transmission channels. The amplitude intensities of these harmonics are defined as independent binary symbols for transmission. The proposed space-time coding digital metasurface can achieve a phase shift of 180° in its unit structure, with reflectivities above 90% at both operating frequencies. We fabricated the designed metasurface and tested its far-field scattering experimentally. When the incident electromagnetic wave frequency is 4.63 GHz, the predicted results are essentially consistent with the experimental findings.
InCHARGE: Co-creating, implementing and evaluating interventions to utilize nurses’ competence and achieve person-centred fundamental care—A research protocol describing an action research approach
Authors: Hauffman Anna , Björk Elin , Edfeldt Katarina , Fröjd Camilla , Gunnarsson Anna-Karin , Nyholm Lena , Avallin Therese , Jangland Eva 
Published: July 2024

Aim and objectives
This research protocol presents an action research project with the aim to demonstrate the value of person-centred fundamental care to nurses and nurse managers in surgical care units to encourage a far-reaching change in this direction. The objectives are to describe this process and to evaluate the effects on missed nursing care and person-centred fundamental care.

Methods
In a novel collaboration between nursing science and medical humanities the action research design will be used to interact with nursing staff and leaders in three surgical care units and design interventions with the purpose to affect the direction of nursing. Initially, the care units will be presented with interactive workshops including evidence-based education on person-centered fundamental care, person-centredness, nurse role responsibility and leadership. This will be followed by cocreation of interventions to stimulate person-centered fundamental care. The Fundamentals of Care framework will be used as the overarching theoretical framework. Data on missed nursing care, person-centred climate and person-centered fundamental care will be collected repeatedly from patient- and nursing stakeholders through interviews and validated questionnaires. Additionally, data from written reflections following clinical observations and focus group interviews will be included. The duration of the study will be approximately five years from ethical approval.

Discussion
It has been previously reported that the current working environments of registered nurses are forcing them to ration their caring responsibilities, leading to a lack of fulfillment of patients’ fundamental care needs, with possible severe consequences for patients. The action research design helps researchers gain an understanding of the contextual factors important for forthcoming interventions, enabling reflective processes and cocreation of interventions with stakeholders. This may lead to feasible interventions and strengthen nursing leadership in the involved units.
Internal Relations and Dialectical Dance Steps in Vygotsky’s Cultural-Historical Psychology
Authors: Xi Jiao 
Published: July 2024

Abstract
The connection between Vygotsky’s Cultural-Historical Psychology (CHP) and the Marxist logic of dialectics is currently gaining focus to promote the development and application of Vygotsky’s psychological theory. However, their interconnection has not been recognized and appreciated to the extent that it deserves, especially in English academia. Dafermos (2018) has clarified the necessity for Vygotskians to rethink cultural-historical psychology from the dialectical perspective to avoid misconceptions. To call for more focus and to deepen theoretical understanding, this study analyzes the philosophical basis of Marxism in CHP by adopting the framework demonstrated by Ollman (2003, 2015) in two connected aspects: 1) internal relations and 2) the dialectical steps involved in abstraction in Marxism. Through analyzing Vygotsky’s texts and elaborating on the conceptual ideas and methodologies in CHP, it presents the connection between CHP and Marxism. Subsequently, it introduces the application of CHP in SLA studies, referred to as Sociocultural Theory-Second Language Acquisition (SCT-SLA), as further evidence to show the impact of Marxist philosophical ideas in practical studies of applied linguistics. Further studies on the relationship between Marxism and CHP, and studies adopting Marxist philosophy to solve SLA issues are encouraged.
Examining the Construction of “Teaching Assessment Literacy”: A Case Study of Teacher Conceptual Development in Collaborative Research Practice
Authors: Yang Luxin , Zhang Ning 
Published: July 2024

Abstract
This study explored the trajectory of teacher concept development during collaborative research practice promoted by a university-school partnership teacher development program. Drawing on Vygotsky’s and Engeström’s notion of concept formation, it examined how a secondary EFL teaching-research officer (TRO) negotiated between scientific and everyday concepts as she co-constructed the research theme “teaching assessment literacy” with mentors and fellow teachers mediated by the program. Multiple sources of data were collected over a span of two years, including six rounds of oral defense and research reporting activities, classroom observations, interviews, journals, and research reports. The analysis showed that the TRO experienced a gradually integrated and transformed path of concept development, and also initiated an expansive learning opportunity for her research participants, triggering collective concept development. While the program played a significant role in providing multi-module facilitating activities, academic-practice joint mentoring and collective scaffolding, more subtle guidance is suggested for the tension-laden process.
Performance of GRKM-method for solving classes of ordinary and partial differential equations of sixth-orders
Authors: Mechee Mohammed S. , Kadhim Murtadha A. , Yazdani Cherati AllahBakhsh 
Published: July 2024

Abstract
A general quasilinear sixth-order ordinary differential equation (ODE) is an important class of ODEs. The primary objective of this study is to establish a numerical method for solving a general class of quasilinear sixth-order partial differential equations (PDEs) and ODEs. However, the Runge–Kutta method (RKM) approach for solving special classes of ODEs has been generalized as an effort to solve the general class of ODEs. Nonlinear algebraic order condition (OCs) equations have been obtained up to the tenth order using the Taylor-series expansion methodology which is used to derive the novel generalized Runge–Kutta method (GRKM). In this study, a GRKM integrator has been derived for solving a general class of quasilinear sixth-order ODEs and then this method is modified subsequently to solve a class of PDEs. Accordingly, the proposed GRKM is modified to solve a quasilinear sixth-order PDE by converting it to a system of sixth-ODEs using the method of lines. Nine problems have been implemented to prove the efficiency and accuracy of the proposed method. Simulation results of these problems showed that the proposed numerical GRKM is an accurate and efficient method. In contrast, by comparing the proposed GRKM numerical approach with the classical RK method, the numerical results demonstrate that the direct integrator outperforms the indirect classical RK method in terms of algorithm complexity and function evaluations, proving that the numerical GRKM is efficient.
Enhancing urban sustainability through industrial synergy: A multidisciplinary framework for integrating sustainable industrial practices within urban settings – The case of Hamadan industrial city
Authors: Al-Asadi Asaad , Almusaed Amjad , Al-Asadi Fatima , Almssad Asaad 
Published: July 2024

Abstract
This study conducts an in-depth analysis of the interplay between sustainable industrial growth and integrated industrial urban environments, proposing a novel paradigm for urban production. The aim of this study is to combine sustainable industrial growth with its integration into urban environments, to establish a new and novel way to seamlessly integrate industrial processes within urban surroundings. This research utilizes a thorough approach, incorporating several disciplines, to examine Hamadan industrial city. It includes an extensive survey of existing literature, a comparative analysis based on empirical evidence, and a detailed evaluation of a specific example. This technique aims to address a significant research gap by providing a comprehensive framework that promotes sustainable industrial practices in urban environments. The scholarly contribution of this work is to manifest in its formulation of a pragmatic framework designed to provide urban planners and policymakers with strategies to harmonize industrial growth with urban sustainability imperatives. This article tackles the considerable challenges posed by escalating urbanization and industrialization. To conceive a framework for urban planning and industrial operations that emphasize environmental stewardship, resource efficiency, and social welfare is the primary purpose of this project. The study shows how industrial cities may revitalize economies, innovate industries, and solve urban problems including housing shortages and congestion. The importance of creative, collaborative, and policy-driven initiatives to build sustainable and resilient industrial–urban ecosystems in global industrial sustainability efforts is highlighted. The findings show that synergistic urban–industrial integration is needed for economic growth, environmental protection, and social welfare.
Unravelling the Experience of Grace: Antecedents, Consequences and Circular Dynamics in the Experience of Grace
Authors: Schellekens Tine , Dillen Annemie , Dezutter Jessie 
Published: July 2024

Abstract
This study consists of seven in-depth-interviews about antecedents and consequences of grace experiences analyzed by CQR. Results indicated that situations of difficulty can provide fertile ground for experiencing grace. Opening up in being and doing were considered to be helpful to recognize and actively receive grace. Participants reported growing closer to themselves, others/the Other and life itself. Through cross-analysis a cluster of circular dynamics emerged encompassing virtues serving as interlinking facilitators regarding the giving and receiving of grace in daily life. This study also suggests that grace experiences may be linked with personal growth processes related to meaning making and virtue- and character development.
Stunting among Children under Five in the Area of Sekaran Primary Healthcare Center, Semarang City
Authors: Hikmah Mamluatul , Cahyati Widya Hary 
Published: July 2024

Abstrak
Pada 2021 prevalensi stunting Indonesia adalah 24,4%, di atas ambang batas prevalensi stunting yang ditetapkan WHO yakni 20%. Pada September 2022, prevalensi stunting di Puskesmas Sekaran adalah 3,27% lebih tinggi dibandingkan prevalensi stunting Kota Semarang pada September 2022 yaitu 1,61%. Merupakan penelitian observasional analitik dengan rancangan nested case-control yang dilaksanakan di Puskesmas Sekaran pada September-Desember 2022. Data yang digunakan merupakan data sekunder hasil reading diagnostic stunting pada penimbangan balita bulan September 2022, data ANC (K1), dan data persalinan di Puskesmas Sekaran. Sampel berjumlah 85 kasus dan 85 kontrol yang dianalisis secara univariat dan bivariat. Penelitian ini bertujuan untuk mengetahui faktor yang berhubungan dengan terjadinya stunting pada balita (0-59 bulan) di wilayah kerja Puskesmas Sekaran. Hasil uji statistik menunjukkan p-value untuk usia balita adalah p=0,009 dan panjang badan lahir adalah p= 0.0001, sehingga dapat disebutkan terdapat hubungan yang signifikan antara usia balita dan panjang badan lahir dengan kejadian stunting.

Abstract
In 2021 Indonesia's stunting prevalence was 24.4%, above the stunting prevalence threshold set by WHO, which is 20%. In September 2022, stunting prevalence at the Sekaran Primary Healthcare Center was 3.27% higher than the stunting prevalence in Semarang City in September 2022 which was 1.61%. This is an analytic observational study with a nested case-control design that was carried out at the Sekaran Primary Healthcare Center in September-December 2022. The data used is secondary data from stunting reading diagnostic September 2022, ANC (K1), and maternal delivery data. The sample consisted of 85 cases and 85 controls which were analyzed univariately and bivariately. This study aims to determine factors associated with the incidence of stunting in under-five children (0-59 months) in the Sekaran Primary Healthcare Center. Statistical tests showed p-value for children’s age is p=0,009 and birth length is p= 0.0001, so it can be said that there is a significant relationship between children’s age and birth length with the incidence of stunting.
Kejadian Leptospirosis di Kabupaten Kebumen Tahun 2022
Authors: Inayah Nelatun , Santik Yunita Dyah Puspita 
Published: July 2024

Abstrak
Kasus leptospirosis di Kabupaten Kebumen pada tahun 2022 mengalami peningkatan dengan jumlah kasus 62 kasus dan 9 kematian (CFR 14,5 %). Tujuan dilakukan penelitian yaitu untuk mengetahui faktor-faktor risiko yang berhubungan dengan kejadian leptospirosis di Kabupaten Kebumen. Jenis penelitian ini adalah observasional analitik dengan desain penelitian kasus kontrol (case control study) yang bersifat retrospektif dengan jumlah sampel 30 kasus dan 30 kontrol yang diambil dengan teknik purposive sampling dengan memperhatikan kriteria inklusi dan eksklusi. Pengambilan data dilakukan pada bulan Januari-Februari tahun 2023 dengan cara wawancara serta pengisian kuesioner. Data dianalisis secara univariat dan bivariat dengan chi-square test. Hasil penelitian menunjukan bahwa pekerjaan (p-value=0,038), riwayat luka (p-value=0,005), riwayat aktivitas di air (p-value=0,000), penggunaan APD (p-value=0,000), dan personal hygiene (p-value=0,037) berhubungan dengan kejadian leptospirosis. Simpulan dalam penelitian ini adalah pekerjaan berisiko, memiliki riwayat luka, memiliki riwayat aktivitas di air, tidak menggunakan APD, dan personal hygiene yang buruk berhubungan dengan kejadian leptospirosis di Kabupaten Kebumen.
Abstract
Leptospirosis cases in Kebumen Regency in 2022 have increased with a total of 62 cases and 9 deaths (CFR 14.5%). The aim of the research was to determine the risk factors associated with the incidence of leptospirosis in Kebumen District. This type of research is analytic observational with a retrospective case control study design with a sample size of 30 cases and 30 controls taken by purposive sampling technique taking into account inclusion and exclusion criteria. Data collection was carried out in January-February 2023 by means of interviews and filling out questionnaires. Data were analyzed univariately and bivariately with the chi-square test. The results showed that occupation (p-value=0.038), history of injury (p-value=0.005), history of activity in water (p-value=0.000), use of PPE (p-value=0.000), and personal hygiene (p-value=0.037) related to the incidence of leptospirosis. The conclusions in this study are risky work, having a history of injuries, having a history of activity in water, not using PPE, and poor personal hygiene are associated with the incidence of leptospirosis in Kebumen Regency.
Pengetahuan dan Sikap dengan Kepatuhan Penggunaan APD pada Pekerja Instalasi dan Teknik
Authors: Prasetyo Silfadhilla Ananda , Widowati Evi 
Published: July 2024

Abstrak
Kecelakaan kerja adalah kejadian yang tidak dikehendaki dan tidak terduga sehingga menyebabkan adanya korban jiwa dan atau harta benda. Hampir 50% kecelakaan kerja di Perumda Air Minum Tirta Kahuripan Kabupaten Bogor terjadi pada bagian instalasi, 45% pada bagian teknik, dan 5% pada bagian lainnya. Oleh sebab itu, penggunaan APD sangatlah penting bagi pekerja bagian instalasi dan bagian teknik sebagai salah satu upaya mengurangi risiko terjadinya kecelakaan kerja. Penelitian yang bertujuan untuk mengetahui hubungan antara pengetahuan dan sikap dengan kepatuhan penggunaan APD dilaksanakan pada tahun 2022. Metode penelitian ini adalah kuantitatif dengan desain cross sectional. Pengambilan sampel menggunakan teknik total sampling yang berjumlah 35 pekerja bagian instalasi dan bagian teknik. Instrumen yang digunakan adalah kuesioner dan lembar observasi. Hasil penelitian yang diolah menggunakan uji fisher menunjukkan bahwa variabel pengetahuan (p=0,105) dan sikap (p=0,181) tidak ada hubungan dengan kepatuhan penggunaan APD. Simpulan penelitian ini, yaitu tidak terdapat hubungan antara pengetahuan dan sikap dengan kepatuhan penggunaan APD.

Abstract
Work accidents are unwanted and unexpected events that cause loss of life and property. Nearly 50% of work accidents at Water Supply Company X happened in the installation section, 45% in the engineering section, and 5% in other sections. Therefore, the use of PPE is very important for workers in the installation and engineering sections as an effort to reduce the risk of work accidents. The research which aims to determine the relation between knowledge and attitude of PPE use compliance. It was done in 2022. This research method was quantitative with cross sectional study. The sampling technique used was total sampling on 35 workers in the installation and engineering sections. The instruments used were questionnaires. Based on the fisher test, the p-value are p=0,105 (knowledge) and p=0,181 (attitude). The conclusion of this study is there was no significant relation between knowledge and attitude with PPE use compliance.
Identification of Dengue Hemorrhagic Fever Risk Zone in Daerah Istimewa Yogyakarta Province 2021
Authors: Rahmat Sultan Aulia , Ningrum Dina Nur Anggraini , Suharna Suharna 
Published: July 2024

Abstrak
Daerah Istimewa Yogyakarta (DIY) merupakan salah satu wilayah endemik Demam Berdarah Dengue (DBD) di Indonesia. Pada 2021, Incidence Rate (IR) DIY mencapai 32/100.000 populasi dengan Case Fatality Rate (CFR) mencapai 1,01%. Untuk mengurangi jumlah kasus DBD diperlukan suatu tindakan pencegahan. Manajemen penyakit berbasis wilayah dapat menjadi solusi mengurangi kasus DBD, seperti pemetaan risiko penyakit. Penelitian ini bertujuan untuk mengetahui tingkat risiko penularan DBD di Provinsi DIY tahun 2021. Penelitian ini merupakan studi cross-sectional dengan pendekatan pemetaan dan ekologis. Variabel faktor risiko yang berkorelasi dengan insiden DBD akan di skoring, kemudian hasilnya dijabarkan menggunakan peta risiko DBD. Penelitian dilaksanakan pada bulan September-Oktober tahun 2022. Berdasarkan analisis bivariat, faktor iklim memiliki hubungan dengan kejadian DBD. Pada Bulan Januari, wilayah Kota Yogyakarta dan Kulon Progo berada dalam risiko tinggi. Pada bulan November, wilayah Gunungkidul berada dalam risiko tinggi. Pada bulan Desember daerah dengan kategori tinggi antara lain Bantul dan Gunungkidul. Distribusi risiko DBD di DIY meningkat selama musim hujan. Pembuat kebijakan diharapkan dapat memprioritaskan daerah berisiko tinggi dalam menciptakan kebijakan.

Abstract
Daerah Istimewa Yogyakarta (DIY) is one of dengue endemic regions in Indonesia. In 2021, Dengue Hemorrhagic Fever (DHF) Incidence Rate (IR) in DIY was 32/100,000 population with Case Fatality Rate (CFR) reaching 1.01%. Reducing DHF cases is necessary to take preventive actions. Area-based disease management can be a solution to reduce DHF cases, such as mapping analysis of disease risk map. This research aims to determine the DHF transmission risk level in DIY Province during 2021. It is a cross-sectional study with mapping and ecological approach. Risk factors that correlate with DHF incidence will be scored, then the results will described as risk map. This research was conducted in September-October 2022. Based on bivariate analysis, climatic factors have a correlation with DHF. In January, Yogyakarta City and Kulon Progo were in high risk. Gunungkidul was highly vulnerable. in November. In December regions with high category include Bantul and Gunungkidul. DHF risk distribution in DIY was increased during rainy season. Policy makers are expected to prioritize high-risk areas in creating policies.