bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of plasma endothelial microparticles in pre-eclampsia
Authors: Ling Li , Huang Huaping , Zhu Lingyun , Mao Ting , Shen Qian , Zhang Hong 
Published: December 2013

Objective To compare the antepartum and postpartum plasma concentrations of endothelial microparticles (EMPs) in patients with pre-eclampsia with those of healthy control subjects with normal pregnancies. Methods Plasma concentrations of EMPs were measured using specific antibody labelling and flow cytometry prior to delivery by caesarean section (antepartum), and again at 24 h and 72 h postpartum. The correlations between EMP concentration and mean arterial pressure (MAP), and between EMP concentration and 24-h urine protein were analysed. Results A total of 59 patients with pre-eclampsia and 60 healthy control subjects participated in the study. The antepartum plasma EMP concentration was significantly higher in patients with pre-eclampsia than in healthy control subjects with normal pregnancies (2863.5 ± 1543.1 versus 1703.0 ± 592.2 EMPs/ml, respectively); similar findings were observed at 24 h postpartum (1836.7 ± 1153.8 versus 1421.8 ± 760.2 EMPs/ml, respectively). There was no significant difference between the two groups at 72 h postpartum. The antepartum plasma EMP concentration in patients with pre-eclampsia demonstrated a significant positive correlation with MAP ( r = 0.716) and with 24-h urine protein ( r = 0.770). Conclusion Plasma EMP concentration might serve as a biomarker to evaluate the severity of pre-eclampsia in the future.
Current Health-Related Quality of Life Is Lower in Former Division I Collegiate Athletes Than in Non–Collegiate Athletes
Authors: Simon Janet E. , Docherty Carrie L. 
Published: December 2013

Background: College athletes participate in physical activity that may increase chronic stress and injury and induce overtraining. However, there is little known about how previous injuries that have occurred during college may limit current physical activity and/or decrease their subsequent health-related quality of life (HRQoL). Purpose: To evaluate HRQoL in former United States National Collegiate Athletic Association Division I athletes and nonathletes with the Patient-Reported Outcomes Measurement Information System (PROMIS) and a demographics questionnaire. Study Design: Cohort study (prognosis); Level of evidence, 2. Methods: The study sample was recruited through alumni databases at a large Midwestern university and consisted of 2 cohorts: (1) former Division I athletes and (2) nonathletes who participated in recreational activity, club sports, or intramurals while attending college. Participants answered a survey constructed with a web-based system. All individuals contacted were between the ages of 40 and 65 years. Study participants responded to the questions on the PROMIS scales for sleep, anxiety, depression, fatigue, pain interference, physical function, and satisfaction with participation in social roles. The PROMIS was developed to fill the void of HRQoL being evaluated by multiple instruments. An additional questionnaire was constructed to record demographic and exercise information. Results: Initially, 1280 former Division I athletes and nonathletes were contacted; 638 surveys were returned (49.8%). Surveys eligible for analyses (71.6%) were completed by 232 former Division I athletes (mean age ± SD, 53.36 ± 7.11 years) and 225 nonathletes (mean age ± SD, 53.60 ± 6.79 years). Univariate analyses for the effect of group was significantly related to PROMIS scales for physical function, depression, fatigue, sleep disturbances, and pain interference ( P < .05). The overall scores were significantly worse for the former Division I athletes than for the nonathletes on 5 of the 7 scales. In addition, the former Division I athletes reported significantly more limitations in daily activities and more major and chronic injuries than did the nonathlete controls. Conclusion: According to these data, former Division I athletes have decreased HRQoL compared with nonathletes. Clinical Relevance: Sports encourage physical activity, which help promote a healthy lifestyle. Moderate activity and exercise should be encouraged. However, the demands of Division I athletics may result in injuries that linger into adulthood and possibly make participants incapable of staying active as they age, thereby lowering their HRQoL.
Femoral Tunnel Enlargement After Medial Patellofemoral Ligament Reconstruction
Authors: Berard Jean-Baptiste , Magnussen Robert A. , Bonjean Grégoire , Ozcan Soner , Lustig Sebastien , Neyret Philippe , Servien Elvire 
Published: December 2013

Background: In recent years, significantly more attention has been focused on the role of the medial patellofemoral ligament (MPFL) in patellar stability, and MPFL reconstruction has become a mainstay of surgical treatment of episodic patellar dislocations. Although previously described in detail after reconstruction of the anterior cruciate ligament, tunnel enlargement has not been investigated after MPFL reconstruction. Hypotheses: (1) Femoral tunnel enlargement occurs after MPFL reconstruction. (2) Patella alta, trochlear dysplasia, and tunnel malposition are risk factors for tunnel enlargement. (3) The presence of tunnel enlargement is not associated with recurrent dislocations or poorer patient-reported outcome scores after MPFL reconstruction. Study Design: Case-control study; Level of evidence, 3. Methods: Fifty-five of 59 knees treated for episodic patellar dislocations with MPFL reconstruction between 2005 and 2010 were evaluated at 1 year postoperatively for the presence of tunnel enlargement on lateral radiographs. Tunnel enlargement was defined as a tunnel area greater than 2 times that of the original tunnel. Knees with tunnel enlargement at 1 year were compared with those without tunnel enlargement. Patients were assessed for recurrent subluxations or dislocations at a mean of 3 years postoperatively, and patient-reported outcome scores were assessed in a subset of patients at a mean of 3.7 years postoperatively. Results: Tunnel enlargement was noted in 23 knees (41.8%). No differences in patient age or body mass index were noted between the 2 groups. The mean patellar height was significantly higher in the enlarged tunnel group ( P = .03). A higher prevalence of trochlear dysplasia or tunnel malposition was not demonstrated in the enlarged tunnel group. Patient-reported outcome scores and the risk of recurrent patellar instability were equal in the 2 groups. Conclusion: Femoral tunnel enlargement after MPFL reconstruction is common, with patients with patella alta at an increased risk. The influence of tunnel malposition and trochlear dysplasia on this condition requires further research. Recurrent instability and patient-reported outcome scores are not affected by tunnel enlargement.
Health-Related Quality of Life After Anterior Cruciate Ligament Reconstruction
Authors: Filbay Stephanie R. , Ackerman Ilana N. , Russell Trevor G. , Macri Erin M. , Crossley Kay M. 
Published: December 2013

Background: Anterior cruciate ligament reconstructions (ACLRs) are frequently performed on young, active patients and can result in persistent knee symptoms and activity limitations that may affect health-related quality of life (HRQoL). To date, there has been no systematic review of HRQoL outcomes after ACLR. Purpose: The objectives of this study were to report HRQoL ≥5 years after ACLR, compare HRQoL outcomes with available population norms, and describe factors that may affect HRQoL in this population. Study Design: Systematic review. Methods: All studies reporting HRQoL ≥5 years after ACLR with hamstring or patellar tendon autografts were eligible for review. Common HRQoL outcomes were pooled using a random-effects meta-analysis and compared with published population norms. The Spearman rank correlation coefficient (ρ) was used to identify variables associated with HRQoL outcomes. Where insufficient data were available, outcomes were reported descriptively. Results: Fourteen studies were eligible for review, and HRQoL was reported for 2493 patients at a mean of 9 years (range, 5-16 years) after ACLR. Pooling of knee-related quality of life outcomes (Knee injury and Osteoarthritis Outcome Score [KOOS]–QOL) found impairments after ACLR when compared with population norms. In comparison, studies using the Short Form–36 (SF-36) reported similar or better HRQoL compared with normative data. The KOOS-QOL subscores correlated strongly with KOOS-sport/recreation (ρ = .70, P = .04) and KOOS-pain (ρ = .85, P = .003) subscores. Severe radiographic osteoarthritis, meniscal injuries sustained after surgery, and revision ACLR were associated with poorer HRQoL outcomes at a minimum 5-year follow-up. The negative influence of concomitant meniscal surgery on HRQoL became apparent more than 10 years after ACLR. Conclusion: This review found that patients assessed using a knee-specific measure (KOOS-QOL) were more likely to report poorer HRQoL values, compared with population norms, than those assessed using a generic HRQoL measure (SF-36). Revision surgeries, meniscal injuries, and severe radiographic osteoarthritis were associated with poorer HRQoL outcomes after ACLR. However, these relationships should be interpreted with caution, as they were only investigated in a small number of studies. Clinical Relevance: These results can be used by clinicians to educate patients about potential long-term outcomes after ACLR and to develop strategies for optimizing postoperative HRQoL.
Poly(vinylidene-trifluoroethylene)/barium titanate composite for in vivo support of bone formation
Authors: Lopes Helena B , Santos Thiago de S , de Oliveira Fabiola S , Freitas Gileade P , de Almeida Adriana LG , Gimenes Rossano , Rosa Adalberto L , Beloti Marcio M 
Published: December 2013

In this study, we evaluated the effect of poly(vinylidene fluoride-trifluoroethylene)/barium titanate (P(VDF-TrFE)/BT) membrane on in vivo bone formation. Rat calvarial bone defects were implanted with P(VDF-TrFE)/BT and polytetrafluoroethylene (PTFE) membranes, and at 4 and 8 weeks, histomorphometric and gene expression analyses were performed. A higher amount of bone formation was noticed on P(VDF-TrFE)/BT compared with PTFE. The gene expression of RUNX2, bone sialoprotein, osteocalcin, receptor activator of nuclear factor-kappa B ligand, and osteoprotegerin indicates that P(VDF-TrFE)/BT favored the osteoblast differentiation compared with PTFE. These results evidenced the benefits of using P(VDF-TrFE)/BT to promote new bone formation, which may represent a promising alternative to be employed in guided bone regeneration.
A surge in anti-dsDNA titer predicts a severe lupus flare within six months
Authors: Pan N , Amigues I , Lyman S , Duculan R , Aziz F , Crow MK , Kirou KA 
Published: December 2013

Objective Rising anti-double-stranded (ds) DNA titers have been shown by some, but not all, studies to be predictive of disease flares in systemic lupus erythematosus (SLE). We hypothesized that a rapid and substantial rise in anti-dsDNA titer (anti-dsDNA surge) would be a good predictor of a clinically important SLE flare. Methods A matched case-control study was conducted in an academic rheumatology practice setting. Our primary endpoint was the occurrence of a severe SELENA-SLEDAI (SS) flare within six months of an anti-dsDNA surge, and secondary endpoints were mild/moderate SS flares, as well as BILAG A and B renal flares. Cases were identified as those patients whose disease course included a surge of anti-dsDNA, defined as an increase of anti-dsDNA titer by the Crithidia luciliae immunofluorescence (CLIF) assay from 0 to 3+/4+, or from 1+ to 4+, within a period of less than 12 months. The date of the anti-dsDNA surge was defined as Day 0. Two control SLE patients were identified for each case and were matched for age, sex, race, and visit date closest to case Day 0, but without an anti-dsDNA surge. Logistic regression models were used to detect associations between anti-dsDNA surges and severe SS flares. Result A higher proportion of cases, compared to controls, experienced a severe SS flare within six months of Day 0 (OR 6.3 (95% confidence intervals 2.0–19.9), p = 0.02). Associations with all flares and hospitalizations for flares were also observed. However, an anti-dsDNA surge was not predictive of a renal flare. Conclusion An anti-dsDNA surge predicts the subsequent development of a severe SS flare within six months. Physicians should closely monitor such patients and treat promptly at the first sign of clinical activity.
Morbidity and Complications Following Percutaneous Calcaneal Autograft Bone Harvest
Authors: O’Malley Martin J. , Sayres Stephanie C. , Saleem Omar , Levine David , Roberts Matthew , Deland Jonathan T. , Ellis Scott 
Published: December 2013

Background: Autogenous bone grafting is commonly used as an adjuvant in foot and ankle procedures. The iliac crest and tibia are common sources of autogenous bone graft but require a separate operative site and have been reported to have significant morbidity including pain, fractures, and prolonged hospitalization. Bone grafting from the posterolateral calcaneus offers advantages such as a single operative field, ability to be done under an ankle block, and a theoretical low complication rate. We report our morbidity and complications of percutaneous calcaneal autograft bone harvest in patients undergoing foot operations. Methods: Between 2006 and 2010, 6 foot and ankle surgeons performed a calcaneal bone graft on 393 patients undergoing foot procedures. Outcomes were measured through the use of a 4-question survey evaluating pain, subjective sensitivity at the incision site, numbness at the incision site, and limitation of shoe wear at a minimum of 1 year following the operation. Patient records were also examined for any additional complications that may have been reported. Results: Of the 393 patients eligible for this study, 210 patients responded at an average of 2.8 years (range, 1.2-5.8 years) after the operation (minimum 1 year). Of those, 181 patients (86.2%) reported no problems. Minor complications included 6 patients (2.9%) who experienced only incisional nerve sensitivity, 4 patients (1.9%) with only incisional pain, 4 patients (1.9%) who reported some degree of incisional numbness only, 2 patients (1.0%) who reported only shoe wear limitations, and 10 patients (4.8%) who had a combination of symptoms. Three patients (1.4%) had more significant complications, which consisted of a pathological fracture through the graft site, a calcaneal stress fracture, and 1 patient with permanent numbness along the distribution of the sural nerve. Conclusion: Calcaneal bone graft was an easily accessible source of local autogenous bone graft for foot and ankle procedures. Despite the simplicity of the procedure, minor complications are not infrequent, with 13.8% of patients reporting some residual symptoms along the lateral border of the calcaneus when bone graft was obtained through an oblique incision. Level of Evidence: Level IV, case series.
Long-Term Results of Debridement and Primary Repair of Peroneal Tendon Tears
Authors: Demetracopoulos Constantine A. , Vineyard Joseph C. , Kiesau Carter D. , Nunley James A. 
Published: December 2013

Background: Peroneal tendon tears are relatively common; however, there are few reports on the long-term success of operative treatment. The purpose of this study was to review the long-term clinical and patient-reported outcomes of a cohort of patients with peroneal tendon tears treated with debridement and primary repair. Methods: Patients who underwent debridement and primary repair of tears of the peroneus longus and brevis from 1994 to 2008 were included in the study. A chart review was performed to determine patient demographics, postoperative complications, and return to sport. Clinical outcomes scores used to assess patients preoperatively and at most recent follow-up included a visual analog scale (VAS) for pain, the SF-12 Health Survey, and the Lower Extremity Functional Scale (LEFS) questionnaire. Results: We identified 34 patients with a tear of one or both peroneal tendons treated operatively by a single surgeon. Eighteen patients participated in the follow-up survey with an average follow-up time of 6.5 years (range, 2-14 years). There was significant improvement in mean VAS pain scores at the time of final follow-up ( P < .001) from a mean of 39 (range, 0-80) preoperatively to a mean of 10 (range, 0-52) postoperatively. In addition, there was a significant increase in the LEFS score from a mean of 45 (range, 23-70) preoperatively to a mean of 71 (range, 24-80) postoperatively ( P < .001). Of the 18 patients who responded, 17 returned to full sporting activity without limitation. There were no reoperations or operative failures during this time interval. Conclusions: Our study found excellent long-term functional outcomes for patients with tears of the peroneal tendons treated with debridement and primary operative repair. Moreover, we observed that the majority of patients returned to their previous level of activity without the need for reoperation or revision of the repair. Level of Evidence: Level IV, case series.
Small bowel stricture characterization and outcomes of dilatation by double-balloon enteroscopy: a single-centre experience
Authors: Gill Raghubinder S. , Kaffes Arthur J. 
Published: December 2013

Background: There is little data on the role of balloon enteroscopy and small bowel strictures. We aim to characterize the diagnostic role of double balloon enteroscopy (DBE) in small bowel strictures and document the outcomes of dilatation. Methods: This is a retrospective review from a single tertiary referral centre DBE database from July 2004 to September 2012. All patients with suspected strictures in the small bowel undergoing DBE were included. The position of the small bowel strictures considered for dilatation was determined by diagnostic imaging, i.e. CT enterography, MR enterography or capsule endoscopy in the workup before DBE. Endpoints included stricture description, dilatation parameters and response to treatment. Main outcome measurements were the safety and efficacy of DBE and dilatation. Results: From our DBE database of 594 patients, a total of 32 patients underwent 44 DBE procedures for suspected or known strictures. Stricture aetiology included Crohn’s disease (CD), nonsteroidal anti-inflammatory drugs (NSAIDs), surgical, Beçhets disease and one unknown. A total of 17 patients did not undergo dilatation as the strictures were ulcerated, nonobstructing or of uncertain aetiology. From the total of 25 dilatations in 15 patients that were attempted, 8/15 (53%) patients had 1 dilatation, 5 patients had 2 dilatations, 1 had 3 dilatations and 1 had 4 dilatations. The mean dilatation diameter was 14 mm. Three patients underwent surgery post-dilatation (2 for perforation). Mean follow up was 16 months. Conclusion: DBE is a useful method in determining the need for dilatation by assessing for active ulceration. Dilatation is effective in the 10–18 mm range, however perforation does occur.
Freiberg’s Infraction
Authors: Talusan Paul G. , Diaz-Collado Pablo J. , Reach John S. 
Published: December 2013

Freiberg’s infraction is a condition of cartilage degeneration of the lesser metatarsal heads. Adolescent females are the “textbook” patients but both males and females may present with this condition later in life. The second and third metatarsals are the most commonly affected, while involvement of the fourth and fifth is rare. The incidence is higher in females than in males. The pathophysiology is unknown, but studies suggest a combination of vascular compromise, genetic predisposition, and altered biomechanics. Diagnosis is made clinically and imaging is used to confirm. Early in the process, radiographs are normal however bone scans may demonstrate a photopenic center with a hyperactive collar and magnetic resonance imaging can reveal hypointensity of the metatarsal head. As Freiberg’s infraction progresses, radiographs show a flattened and fragmented metatarsal head. Nonoperative treatment is based on decreasing foot pressure and unloading the affected metatarsal. Spontaneous healing with remodeling may occur in early stages of the disease. Operative options are dorsal closing wedge osteotomies, osteochondral transplant, and resection arthroplasty. Currently, we do not understand this disease sufficiently to prevent its occurrence. Outcomes of nonoperative and operative management are good to excellent and most patients are able to return to previous activity. Levels of Evidence: Therapeutic, Level IV
Idiopathic Cam Morphology Is Not Caused by Subclinical Slipped Capital Femoral Epiphysis
Authors: Monazzam Shafagh , Bomar James D. , Pennock Andrew T. 
Published: December 2013

Background: Cam impingement as a known sequelae of slipped capital femoral epiphysis (SCFE) has led to speculation that subclinical SCFEs may be the causative factor in idiopathic cam morphology; alternatively, others have implicated an abnormal extension of the growth plate as a causative factor. Hypothesis/Purpose: To investigate the growth plate tilt angle in 4 patient cohorts: normal patients, patients with idiopathic cam morphology (CamIP), patients with cam morphology secondary to known SCFE (CamSCFE), and patients with incidental findings of an asymptomatic cam (Camasymp). Study Design: Case-control study; Level of evidence, 3. Methods: A database of 192 computed tomography scans of abdomens/pelvises of patients (ages, 5-19 years) with no known orthopaedic issues, reformatted to neutral tilt, inclination, and rotation, were utilized for the normal cohort, the Camasymp cohort, and to create an age- and sex-matched control cohort. In addition, a retrospective review of all patients treated for femoroacetabular impingement (FAI) with preoperative advance imaging was conducted, and patients were separated to CamIP and CamSCFE cohorts. The alpha angle and tilt angle were measured on each hip. Statistical analysis was performed. Results: The mean tilt angle among the normal patients was 12.1°, with 1.9% of the variation in tilt angle being explained by age; each additional year of age decreased the tilt angle by 0.27° ( P = .008). The tilt angle for the CamSCFE cohort (mean, 44.5°) was found to be significantly greater than both the CamIP cohort (mean, 5.9°; P < .001) and the control cohort (mean, 12.8°; P < .001). The tilt angle for the CamIP cohort was found to be significantly less than the control cohort ( P = .003). The alpha angle and tilt angle were positively correlated in the CamIP cohort, but no correlation was found in the other cohorts. The mean tilt angle of the 18 hips in the Camasymp cohort was 13.9° ± 11.5° (range, –12° to 37°), with 12 hips (67%) in the tilt angle range of CamIP cohort and 6 in the tilt angle range of CamSCFE. Conclusion: The proximal femoral growth plate normally has a posterior tilt that becomes more anterior through maturation. Idiopathic cam morphology has a drastically different growth plate tilt angle than cam morphology secondary to SCFE, suggesting that a majority of idiopathic cam morphology is not the result of subclinical SCFEs.