bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Palladium‐Catalyzed Double C—H Activation: One‐Pot Synthesis of Benzo[c]pyrazolo[1,2‐a]cinnolin‐1‐ones from 5‐Pyrazolones and Aryl Iodides.
Authors: Fan Zhoulong , Wu Kui , Xing Li , Yao Qizheng , Zhang Ao 
Published: April 2014

AbstractThe structure of the product (Ve) is confirmed by X‐ray analysis.
ChemInform Abstract: Synthesis of Pyrimidones and Evaluation of Their Xanthine Oxidase Inhibitory and Antioxidant Activities.
Authors: Gurupadaswamy Handuvinahalli Devanna , Girish Virupaksha , Zameer Farhan , Hegdekatte Raghavendra , Chauhan Jyoti Bala , Khanum Shaukath Ara 
Published: April 2014

AbstractTitle compounds (V) exhibit good inhibitory activities against xanthine oxidase.
ChemInform Abstract: An Efficient Synthesis and in vitro Antibacterial Activity of Novel Spiro‐aminopyrimidones.
Authors: Balalaie Saeed , Moghimi Hamid , Bararjanian Morteza , Rominger Frank , Bijanzadeh Hamid Reza , Sheikhahmadi Masoumeh 
Published: April 2014

AbstractAn easy and efficient method for the formation of the title compounds (IV) and (VIII) via three‐component reaction is developed.
ChemInform Abstract: Rapidly and Highly Yielded Synthesis of Pyrimidine, Dihydropyrimidinone, and Triazino[2,1‐b]quinazolin‐6‐ones Derivatives
Authors: Mohamed Shaaban K. , Soliman Ahmed M. , El Remaily Mahmoud A. A. , Abdel‐Ghany H. 
Published: April 2014

Abstractvia reaction of guanidine (I) with several active methylene compounds
ChemInform Abstract: Synthesis of 1,3‐Thiazine‐2,4‐diones with Potential Anticancer Activity.
Authors: Ferreira Misael , Assuncao Laura Sartori , Filippin‐Monteiro Fabiola Branco , Creczynski‐Pasa Tania Beatriz , Sa Marcus Mandolesi 
Published: April 2014

AbstractCompounds (IIb) and (IIf) show selective antitumoral activity against leukemia cells.
ChemInform Abstract: Synthesis of New Schiff Bases and Polycyclic Fused Thiopyranothiazoles Containing 4,6‐Dichloro‐1,3,5‐triazine Moiety.
Authors: Polovkovych Svyatoslav V. , Karkhut Andrew I. , Marintsova Natalia G. , Lesyk Roman B. , Zimenkovsky Borys S. , Novikov Volodymyr P. 
Published: April 2014

AbstractThe screening of the in vitro anticancer activity of the synthesized compounds shows that compounds (IVa), (VIIIb), (VIIId) are the most active compounds against different cell lines.
ChemInform Abstract: Chemistry of Phosphorus Ylides 31: Reaction of Azidocoumarin with Active Phosphonium Ylides, Synthesis and Antitumour Activities of Chromenones.
Authors: Maigali Soher S. , Abd‐El‐Maksoud Mansoura A. , Soliman Fouad M. 
Published: April 2014

AbstractReaction of 4‐azidochromenone (I) with nucleophilic phosphacumulene ylides provides access to new triazole, triazepine, aziridine, and pyrrolone derivatives containing a coumarin moiety.
ChemInform Abstract: Catalytic Enantioselective Michael Addition of α‐Aryl‐α‐isocyanoacetates to Vinyl Selenone: Synthesis of α,α‐Disubstituted α‐Amino Acids and (+)‐ and (‐)‐Trigonoliimine A.
Authors: Buyck Thomas , Wang Qian , Zhu Jieping 
Published: April 2014

AbstractThe title reaction in the presence of a cinchona‐alkaloid affords Michael adducts in excellent yields and enantioselectivities.
ChemInform Abstract: Synthesis of C‐Glycosyl Pyrrolo[3,4‐c]carbazole‐1,3(2H,6H)‐diones as a Scaffold for Check Point Kinase 1 Inhibitors.
Authors: Ichikawa Satochi , Tatebayashi Nana , Matsuda Akira 
Published: April 2014

AbstractCompounds (I) are tested for their potential as Chk1 inhibitors and show good activities with IC50 values of 0.5‐9.5 μM.
ChemInform Abstract: A Cytotoxic Pyrrolidinoindoline Diketopiperazine Dimer from the Algal Fungus Eurotium herbariorum HT‐2.
Authors: Li Ye , Sun Kun‐Lai , Wang Yi , Fu Peng , Liu Pei‐Pei , Wang Chen , Zhu Wei‐Ming 
Published: April 2014

AbstractThe new cytotoxic bispyrrolidinoindoline diketopiperazine alkaloid cristatumin E (I) shows weak antibacterial activity against E.
ChemInform Abstract: Synthesis and Biological Properties of Thiazole‐Analogues of Pyochelin, a Siderophore of Pseudomonas aeruginosa.
Authors: Noel Sabrina , Hoegy Francoise , Rivault Freddy , Rognan Didier , Schalk Isabelle J. , Mislin Gaetan L. A. 
Published: April 2014

AbstractAmong several thiazole analogues of pyochelin synthesized, compounds (I) are the two first pyochelin analogues with the ability to bind FptA (the outer membrane transporter responsible of ferric‐pyochelin uptake) without promoting any iron uptake in P.
ChemInform Abstract: Cytotoxic Xanthones from Hypericum chinense.
Authors: Li Yinke , Xu Yong , Wu Jia , Wang Sujuan , Meng Yanlin , Ye Yanqing , Yang Haiyin , Gao Xuemei , Hu Qiufen 
Published: April 2014

AbstractTwo new xanthones are isolated and their structures are elucidated.
ChemInform Abstract: Sortase A Inhibitory Metabolites from the Roots of Pulsatilla koreana.
Authors: Lee Sooryun , Song Inn‐Hye , Lee Jung‐Ho , Yang Woo‐Young , Oh Ki‐Bong , Shin Jongheon 
Published: April 2014

AbstractThree new lignans (I) and (II) are isolated together with eight known lignans and propanoids from dried roots of Pulsatilla koreana.
A novel quasi‐Z‐source indirect matrix converter
Authors: Liu Shuo , Ge Baoming , You Xuyang , Jiang Xinjian , Abu‐Rub Haitham , Peng Fang Zheng 
Published: April 2014

SummaryA new type of three‐phase quasi‐Z‐source indirect matrix converter (QZS‐IMC) is proposed in this paper. It uses a unique impedance network for achieving voltage‐boost capability and making the input current in continuous conduction mode (CCM) to eliminate the input filter. The complete modulation strategy is proposed to operate the QZS‐IMC. Meanwhile, a closed‐loop DC‐link peak voltage control strategy is proposed, and the DC‐link peak voltage is estimated by measuring both the input and capacitor voltages. With this proposed technique, a high‐performance output voltage control can be achieved with an excellent transient performance even if there are input voltage and load current variations. The controller is designed by using the small‐signal model. Vector control scheme of the induction motor is combined with the QZS‐IMC to achieve the motor drive. A QZS‐IMC prototype is built in laboratory, and experimental results verify the operating principle and theoretical analysis of the proposed converter. The simulation tests of QZS‐IMC based inductor motor drive are carried out to validate the proposed converter's application in motor drive. Copyright © 2013 John Wiley & Sons, Ltd.
Comparison of two liquid preservatives for SurePath™ slides prepared from voided urine
Authors: Ohsaki Hiroyuki , Shigematsu Yumie , Irino Satoshi , Hirakawa Eiichiro , Norimatsu Yoshiaki 
Published: April 2014

Blood‐rich gynecologic specimens can be problematic in the processing of liquid‐based cytology. However, little is known about the influence of erythrocytes and protein on urine specimens. In addition, the SurePath™ system has two preservatives for non‐gynecologic specimens. In this study, we compared the epithelial cell counts and cytomorphology obtained from CytoRich™ (CR) Red and CR Blue.A total of 98 voided urine samples were processed using both CR Red and CR Blue. We made an assessment of the epithelial cell counts, fixation, and staining quality, and backgrounds of both slides. Urine protein and urine erythrocyte counts were analyzed, and those data were compared with the epithelial cell counts in CR Red and CR Blue slides.Overall, epithelial cell counts were equivalent for both CR Red and CR Blue slides. However, in high‐level proteinuria cases, the CR Red slides showed higher epithelial cell counts than the CR Blue slides. On the other hand, in microscopic hematuria cases, the CR Blue slides showed higher epithelial cell counts than the CR Red slides.We have found both CR Red and CR Blue to be available for urine cytology. However, it is important to note that CR Blue is inferior to CR Red in epithelial cell recovery rates in cases of high‐level proteinuria. Diagn. Cytopathol. 2014;42:423–427. © 2013 Wiley Periodicals, Inc.
Testing the measurement invariance of the eating disorder inventory in nonclinical samples of Hispanic and Caucasian women
Authors: Belon Katherine E. , McLaughlin Elizabeth A. , Smith Jane Ellen , Bryan Angela D. , Witkiewitz Katie , Lash Denise N. , Winn Jaime L. 
Published: April 2014

ABSTRACTObjectiveThe factor structure of the Eating Disorder Inventory (EDI) has not been thoroughly tested in Hispanic populations, yet researchers commonly use this instrument in Hispanic samples. Thus, it is important to establish the validity of the EDI in Hispanic populations. This article investigated measurement invariance of the EDI's three eating‐ and weight‐related (eat/wt) scales because they are the most frequently used and are often used in isolation. These scales include Drive for Thinness, Bulimia, and Body Dissatisfaction.MethodFemale undergraduates were recruited for a study on body image. The final sample (N = 688) included participants categorized as Hispanic (N = 385) or Caucasian (N = 303). They completed the EDI‐3 and a measure of acculturation.ResultsMeasurement invariance analyses of the EDI‐3 in Caucasian and Hispanic samples were conducted. The configural model provided an acceptable fit, providing support for the three‐factor structure of the eat/wt scales in both the Caucasian and the Hispanic sample. However, weak invariance of the three‐factor structure was not supported. When measurement invariance analyses were conducted on the three eat/wt scales separately, Drive for Thinness was the only scale to demonstrate measurement invariance.DiscussionThe theoretical three‐factor structure of the EDI eat/wt scales was supported in both ethnic groups. Furthermore, the Drive for Thinness scale can readily be used to make group comparisons across nonclinical samples of Caucasian and Hispanic women, but researchers should be cautious when using the other two eat/wt scales to make comparisons across these two groups. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2015; 48:262–270)
Optical Characterization and Computational Chemical Evaluation of Electronic Localized States in Polyolefin
Authors: Arai Tomoyuki , Hosobuchi Masashi , Fuse Norikazu , Takeda Kyozaburo , Ohki Yoshimichi 
Published: April 2014

SUMMARYOptical absorption spectra and photoluminescence spectra were obtained for eight kinds of polyolefin sheet samples using photons in a range from visible to vacuum ultraviolet (UV). Almost all samples were found to exhibit an absorption peak at around 6.5 eV and a luminescence band at around 4.3 eV. The luminescence was found to be induced by the absorption. Furthermore, it was found that successive absorption of UV photons weakened the luminescence intensity. It is assumed from these results that ‐unsaturated carbonyls are luminous and that the carbonyls are decomposed through the Norrish type II reaction by absorbing UV photons. Quantum chemical calculations were carried out using polyethylene models with and without an unsaturated carbonyl to verify the above‐mentioned assumption. As a result, the model with an unsaturated carbonyl was found to have localized electronic states in the forbidden band. One of the differential energies between the states is close to the photon energy, by which the luminescence is induced. The bond length of a double bond, which is next to the carbonyl, was found to be longer at the excited singlet state than at the ground state. These results obtained by computation support the above‐mentioned assumption of the luminescence center and its decomposition.
Low‐Energy Electron Beam Induced Charging and Secondary Electron Emission Properties of FEP Film Used on Satellite Surfaces
Authors: Fujii Haruhisa , Okumura Teppei , Takahashi Masato 
Published: April 2014

SUMMARYMany kinds of insulating materials are used outside a spacecraft. They include FEP films, polyimide films, and so on, and are used as thermal control materials. These materials are exposed to a charged‐particle environment around the spacecraft. Thus then become charged due to charged particles, especially electrons. It has been pointed out that charging of these materials is likely to cause discharges on the surfaces. From this viewpoint, we investigated the charging potential characteristics of 127‐μm‐thick FEP film, a typical thermal control material, by exposing it to electron irradiation at various energies below 20 keV. In the dependence of the charging potential on the electron energy, we found that the electron energy at which no charge‐up occurs is about 2.7 keV. This appears to be the energy at the which secondary electron emission yield becomes unity. This indicates that electron irradiation of FEP film with energies lower than 2.7 keV induces positive charging. From the charge decay characteristics after electron irradiation, the volume resistivity of the film was also obtained as a function of the electric fields in the bulk of the FEP film.
Studies on a Hybrid Wind Turbine Generating System Using a Current‐Source Thyristor Inverter
Authors: Tatsuta Fujio , Nishikata Shoji 
Published: April 2014

SUMMARYA practical‐scale hybrid wind turbine generating system is developed for generating a constant output power even when the wind velocity fluctuates. The system consists of a wind turbine synchronous generator (SG), a rectifier, a current‐source thyristor inverter, an SG driven by a prime mover, and a duplex reactor. A high‐quality output voltage waveform is always obtained from the system, which has a very simple configuration. Experimental results show the feasibility of the system. A model of the system is also developed to predict the dynamic performance when the system conditions such as the wind velocity and load are changed, and good agreement between the simulated and experimental performance is observed, confirming the validity of the dynamic model.
Regioselective Synthesis of Highly Functionalized Furans Through the RuII‐Catalyzed [3+2] Cycloaddition of Diazodicarbonyl Compounds
Authors: Xia Likai , Lee Yong Rok 
Published: April 2014

AbstractA novel method for the RuII‐catalyzed regioselective synthesis of highly functionalized furans from readily available cyclic and acyclic diazodicarbonyl compounds and terminal alkynes is described. The devised protocol offers a straightforward means to the construction of a variety of diverse furan derivatives through powerful cascade processes, including the formation of ruthenium carbenoid, cyclopropenation, ring‐opening metathesis, and cyclization.
Biogenetically Inspired Total Synthesis of (+)‐Liphagal: A Potent and Selective Phosphoinositide 3‐Kinase α (PI3Kα) Inhibitor from the Marine Sponge Aka coralliphaga
Authors: Kamishima Takaaki , Kikuchi Takuya , Narita Koichi , Katoh Tadashi 
Published: April 2014

AbstractA biologically attractive and structurally unique marine natural product, (+)‐liphagal, was biomimetically synthesized in 29 % overall yield in a longest linear sequence of 13 steps from commercially available (+)‐sclareolide. This synthesis involved the following crucial steps: (i) stereocontrolled hydrogenation of an endo‐olefinic decalin to install the C8 stereogenic centre present in the requisite decalin segment; (ii) coupling of the decalin segment with an aromatic moiety to assemble the desired carbon skeleton; (iii) ring expansion of a proposed biogenetic intermediate followed by benzofuran formation to establish the requisite tetracyclic core structure. A few new aspects of the proposed biosynthetic pathway to this class of natural products were revealed.
Straightforward Access to Hexahydropyrrolo[2,3‐b]indole Core by a Regioselective C3‐Azo Coupling Reaction of Arenediazonium Compounds with Tryptamines
Authors: Stephens David E. , Larionov Oleg V. 
Published: April 2014

AbstractA base‐mediated regioselective electrophilic addition of arenediazonium salts at the C3‐position of tryptamines followed by cyclization provides an efficient entry to C3‐nitrogenated hexahydropyrrolo[2,3‐b]indoles (HPIs) that can subsequently be transformed into 3‐arylhexahydropyrrolo[2,3‐b]indoles and other HPI derivatives. The reaction is the first example of a 1,2‐diamination that utilizes easily accessible arenediazonium salts as nitrogenous electrophiles.
Total Synthesis of (2RS)‐α‐Tocopherol through Ni‐Catalyzed 1,4‐Addition to a Chromenone Intermediate
Authors: Termath Andreas Ole , Velder Janna , Stemmler René T. , Netscher Thomas , Bonrath Werner , Schmalz Hans‐Günther 
Published: April 2014

AbstractA novel strategy for the total synthesis of α‐tocopherol (“vitamin E”) was elaborated on the basis of the conjugate addition of AlMe3 (as a methyl anion equivalent) to a 2‐substituted chromenone. Starting from trimethylhydroquinone and (R,R)‐hexahydrofarnesol, the required chromenone substrate was efficiently prepared in a short sequence exploiting a TiCl4‐mediated Fries rearrangement and a KOtBu‐induced Baker–Venkatamaran rearrangement. The envisioned key step, which sets up the quaternary center at C2, was performed in virtually quantitative yield through Ni‐catalyzed conjugate addition of AlMe3. However, this transformation, which likely proceeds through a radical mechanism, could not be rendered stereoselective by means of chiral ligands. Nevertheless, the elaborated synthesis of (2RS,4′R,8′R)‐α‐tocopherol (2‐ambo‐α‐tocopherol) is efficient and challenges the future development of suitable protocols for the asymmetric 1,4‐addition.
Biological performance of two different 1000 L single‐use bioreactors applying a simple transfer approach
Authors: Minow Benjamin , Tschoepe Susanne , Regner Anja , Populin Maeva , Reiser Sven , Noack Caroline , Neubauer Peter 
Published: April 2014

Process transfer is associated with a considerable risk potential. The most critical equipment aspects in upstream operations are the type and scale of bioreactors. Single‐use systems have the advantage of a relatively fixed bioreactor design where only few adaptations can be made, e.g. in stirrer geometry or type of submerse aeration. Here, we describe the transfer of a Chinese hamster ovary fed‐batch process in the 1000 L scale from aXDR™ to a Thermo Scientific Hyclone Single‐Use Bioreactor (S.U.B.) used forGMPcompliant manufacturing of biologics. The transfer method, which was based on a preceding intensive characterization of both bioreactors, aimed either to keep the oxygen mass transfer or the power input constant. The transfer strategies were evaluated theoretically based on derived empirical correlations for the mass transfer coefficients, kLaO2and kLaCO2. An operation boundary of 10–31 W m−3for theS.U.B.bioreactor was defined, which is an approximately 35 % higher power input compared to that in the XDR™. The transfer strategy succeeded in maintaining essential biological parameters such as cell concentration (±5%), viability (±2%), and product formation (±3%) very similar. This is, to the authors’ knowledge, the first time that distinct process performance comparison in different 1000 LSUBs is published.
Performance evaluation of bromofluoropropene in extinguishing liquid fuel spray fires
Authors: Ni Xiaomin , Chow W. K. 
Published: April 2014

AbstractLiquid fuel spray fires emit high radiation heat fluxes, posing great threat to humans. The study of suitable agents and techniques for extinguishing this particular type of fire is of great importance. In this study, degradable 2‐bromo‐3,3,3‐trifluoropropene (BTP), a new clean fire extinguishing agent, was tested for its effectiveness in extinguishing three types of liquid fuel spray fires, namely diesel, gasoline, and ethanol. Bench‐scale experiments were conducted in a 6 × 5 × 3 m compartment with natural ventilation. The liquid fuels sprayed at varying pressures were ignited by a small open flame and then extinguished by a portable BTP extinguisher. Results showed that BTP of less than 60.0 g could extinguish all liquid fuel spray fires of 0.20 to 1.0 MPa in less than 2.0 s. The results also showed that when compared with fire sparked by gasoline and diesel, it is significantly easier to put out ethanol spray fires because of its high flame temperature and low flame power. Based on well‐established fire suppression theories and experimental results, the detailed mechanism of how BTP functions as an extinguishing agent in the suppression of liquid fuel spray fires will be discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Alterations in amplitude of low frequency fluctuation in treatment‐naïve major depressive disorder measured with resting‐state fMRI
Authors: Liu Jie , Ren Ling , Womer Fay Y. , Wang Jue , Fan Guoguang , Jiang Wenyan , Blumberg Hilary P. , Tang Yanqing , Xu Ke , Wang Fei 
Published: April 2014

AbstractThere are limited resting‐state functional magnetic resonance imaging (fMRI) studies in major depressive disorder (MDD). Of these studies, functional connectivity analyses are mostly used. However, a new method based on the magnitude of low frequency fluctuation (LFF) during resting‐state fMRI may provide important insight into MDD. In this study, we examined the amplitude of LFF (ALFF) within the whole brain during resting‐state fMRI in 30 treatment‐naïve MDD subjects and 30 healthy control (HC) subjects. When compared with HC, MDD subjects showed increased ALFF in the frontal cortex (including the bilateral ventral/dorsal anterior cingulate cortex, orbitofrontal cortex, premotor cortex, ventral prefrontal cortex, left dorsal lateral frontal cortex, left superior frontal cortex), basal ganglia (including the right putamen and left caudate nucleus), left insular cortex, right anterior entorhinal cortex and left inferior parietal cortex, together with decreased ALFF in the bilateral occipital cortex, cerebellum hemisphere, and right superior temporal cortex. These findings may relate to characteristics of MDD, such as excessive self‐referential processing and deficits in cognitive control of emotional processing, which may contribute to the persistent and recurrent nature of the disorder. Hum Brain Mapp 35:4979–4988, 2014. © 2014 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.
A hierarchical method for whole‐brain connectivity‐based parcellation
Authors: Moreno‐Dominguez David , Anwander Alfred , Knösche Thomas R. 
Published: April 2014

AbstractIn modern neuroscience there is general agreement that brain function relies on networks and that connectivity is therefore of paramount importance for brain function. Accordingly, the delineation of functional brain areas on the basis of diffusion magnetic resonance imaging (dMRI) and tractography may lead to highly relevant brain maps. Existing methods typically aim to find a predefined number of areas and/or are limited to small regions of grey matter. However, it is in general not likely that a single parcellation dividing the brain into a finite number of areas is an adequate representation of the function‐anatomical organization of the brain. In this work, we propose hierarchical clustering as a solution to overcome these limitations and achieve whole‐brain parcellation. We demonstrate that this method encodes the information of the underlying structure at all granularity levels in a hierarchical tree or dendrogram. We develop an optimal tree building and processing pipeline that reduces the complexity of the tree with minimal information loss. We show how these trees can be used to compare the similarity structure of different subjects or recordings and how to extract parcellations from them. Our novel approach yields a more exhaustive representation of the real underlying structure and successfully tackles the challenge of whole‐brain parcellation. Hum Brain Mapp 35:5000–5025, 2014. © 2014 Wiley Periodicals, Inc.