bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Novel Spirooxindole—Pyrrolidine Compounds: Synthesis, Anticancer and Molecular Docking Studies.
Authors: Arun Y. , Saranraj K. , Balachandran C. , Perumal P. T. 
Published: July 2014

AbstractA variety of novel spirooxindole‐pyrrolidine derivatives are synthesized by 1,3‐dipolar cycloaddition reactions of azomethine ylides derived from isatin and sarcosine or thiaproline with acrylonitriles (I).
ChemInform Abstract: Synthesis and Biological Evaluation of Benzo[b]furans as Inhibitors of Tubulin Polymerization and Inducers of Apoptosis.
Authors: Kamal Ahmed , Reddy N. V. Subba , Nayak V. Lakshma , Reddy V. Saidi , Prasad B. , Nimbarte Vijaykumar D. , Srinivasulu Vunnam , Vishnuvardhan M. V. P. S. , Reddy C. Suresh 
Published: July 2014

AbstractFunctionalization of key intermediate (IV) furnishes 29 different benzofuran derivatives, e.g. (V).
ChemInform Abstract: A Streamlined Synthesis of 2,3‐Dihydrobenzofurans via the ortho‐Quinone Methides Generated from 2‐Alkyl‐Substituted Phenols.
Authors: Wu Bo , Chen Mu‐Wang , Ye Zhi‐Shi , Yu Chang‐Bin , Zhou Yong‐Gui 
Published: July 2014

AbstractSilver‐oxide‐mediated oxidation of 2‐alkyl‐substituted phenols generates ortho‐quinone methides which are directly trapped with trialkylsulfonium salts in the presence of base to give 2,3‐dihydrofurans in good yields.
ChemInform Abstract: Synthesis and Antimicrobial Evaluation of Amide Derivatives of Benzodifuran‐2‐carboxylic Acid.
Authors: Soni Jigar N. , Soman Shubhangi S. 
Published: July 2014

AbstractThe synthesized compounds with electron withdrawing groups at the para position of the amine exhibit moderate activity against Gram‐positive bacteria B.
ChemInform Abstract: Microwave Assisted Synthesis of Cyclic Carbonates from Olefins with Sodium Bicarbonates as the C1 Source.
Authors: Yang Xiaoqing , Wu Jie , Mao Xianwen , Jamison Timothy F. , Hatton T. Alan 
Published: July 2014

AbstractCompared to conventional heating, microwave heating provides remarkably better selectivities and yields.
ChemInform Abstract: Synthesis of H‐Pyrazolo[5,1‐a]isoquinolines via Silver(I)‐Catalyzed Tandem Reaction of N′‐(2‐Alkynylbenzylidene)hydrazides with Propargyl Amine Derivatives.
Authors: Liu Hongliang , Wang Zhiyong , Pu Shouzhi , Liu Gang 
Published: July 2014

AbstractThe title reaction occurs by a tandem 6‐endo‐cyclization, nucleophilic addition, 5‐endo‐cyclization and aromatization, providing cycloadducts in moderate to good yields with exclusive regioselectivity.
ChemInform Abstract: Eco‐Friendly Synthesis of 2‐Aryl‐1‐arylmethyl‐1H‐benzimidazoles Using Alumina‐Sulfuric Acid as a Heterogeneous Reusable Catalyst.
Authors: Pramanik Amit , Roy Rimi , Khan Sagar , Ghatak Avishek , Bhar Sanjay 
Published: July 2014

AbstractThis atom‐efficient and green methodology is also applicable for the synthesis of quinoxaline frameworks.
ChemInform Abstract: Synthesis and Biological Evaluation of Thiazoline Derivatives as New Antimicrobial and Anticancer Agents.
Authors: Altintop Mehlika Dilek , Kaplancikli Zafer Asim , Ciftci Guelsen Akalin , Demirel Rasime 
Published: July 2014

AbstractAmong the new thiazoline derivatives synthesized, compound (IIIc) is the most promising antibacterial agent against P.
ChemInform Abstract: Novel Synthesis of Isoxazoline Indolizine Amides for Potential Application to Tropical Diseases.
Authors: Zhang Yong‐Kang , Plattner Jacob J. , Zhou Yasheen , Xu Musheng , Cao Jianxin , Wu Qingquan 
Published: July 2014

AbstractThe strategy to synthesize target compounds (I) and (II) via the key intermediates ethyl 8‐acetylindolizine‐5‐carboxylate and methyl 5‐formylindolizine‐8‐carboxylate, resp., is outlined.
ChemInform Abstract: Synthesis and Antiproliferative Evaluation of 13‐Aryl‐13H‐benzo[g]benzothiazolo[2,3‐b]quinazoline‐5,14‐diones.
Authors: Wu Liqiang , Zhang Chong , Li Weilin 
Published: July 2014

AbstractMost of the new compounds (IV) (10 examples) show good to potent cytotoxic activities against two human cancer cell lines (HepG2 and HeLa).
ChemInform Abstract: Synthesis of Novel Ring‐A Fused Hybrids of Oleanolic Acid with Capabilities to Arrest Cell Cycle and Induce Apoptosis in Breast Cancer Cells.
Authors: Mallavadhani Uppuluri Venkata , Vanga Nagi Reddy , Jeengar Manish Kumar , Naidu V. G. M. 
Published: July 2014

AbstractSix novel oleanolic acid hybrids are synthesized and evaluated for their anticancer activities.
ChemInform Abstract: Penibruguieramine A, a Novel Pyrrolizidine Alkaloid from the Endophytic Fungus Penicillium sp. GD6 Associated with Chinese Mangrove Bruguiera gymnorrhiza.
Authors: Zhou Zhen‐Fang , Kurtan Tibor , Yang Xiao‐Hong , Mandi Attila , Geng Mei‐Yu , Ye Bo‐Ping , Taglialatela‐Scafati Orazio , Guo Yue‐Wei 
Published: July 2014

AbstractThe isolation, structure elucidation and biosynthetic pathway of the title compound are described.
ChemInform Abstract: Lithium Hydrazinidoborane: A Polymorphic Material with Potential for Chemical Hydrogen Storage.
Authors: Moury Romain , Demirci Umit B. , Ban Voraksmy , Filinchuk Yaroslav , Ichikawa Takayuki , Zeng Liang , Goshome Kiyotaka , Miele Philippe 
Published: July 2014

AbstractPolymorphic LiN2H4BH3 (LiHB) hydrogen storage material is prepared mechanochemically from equimolar amounts of N2H4BH3 and LiH (ball milling, 200 rpm, 18 x 10 min).
PEG600‐Carboxylates as Efficient Reusable Reaction Media and Acylating Agents for the Resolution of sec‐Alcohols
Authors: Monteiro Carlos M. , Lourenço Nuno M. T. , Ferreira Frederico C. , Afonso Carlos A. M. 
Published: July 2014

AbstractHerein is presented a simple, attractive, and reusable methodology for one‐pot resolution/separation of free sec‐alcohols with enantiomeric excess (ee) values over 90 % by the combination of sustainable acylating agents/solvents (polyethylene glycol derivatives) and an easily available and common biocatalyst (Candida antarctica lipase B, or CAL B) under irreversible conditions, along with a separation process by extraction or distillation. A scale‐up reaction was carried out with the Fluoxetine precursor with ee values close to 90 % for the R enantiomer.
Diabetes mellitus is associated with elevated risk of mortality amongst patients with prostate cancer: a meta‐analysis of 11 cohort studies
Authors: Cai Hongzhou , Xu Zicheng , Xu Ting , Yu Bin , Zou Qing 
Published: July 2014

AbstractPurposeDiabetes mellitus is associated with a decreased risk of prostate cancer. However, previous studies examining the associations between diabetes mellitus and prostate cancer prognosis have produced mixed results. Here, we aim to summarize the effect of diabetes mellitus on prostate cancer prognosis.MethodsWe searched the database of PubMed from inception through 31 March 2014 for articles evaluating the effect of diabetes on outcome in prostate cancer patients, and a meta‐analysis was conducted.ResultsA total of 11 cohort studies were included in this meta‐analysis, of which seven studies were carried out to investigate whether diabetes mellitus is associated with all‐cause mortality amongst those with prostate cancer, seven studies to investigate whether diabetes mellitus is associated with prostate cancer‐specific mortality and two studies to investigate the relationship of diabetes mellitus and nonprostate cancer mortality. The meta‐analysis results suggested that diabetes mellitus could significantly affect the incidence of all‐cause mortality amongst those with prostate cancer (hazard ratio = 1.50, 95% confidence interval = 1.25–1.79). Besides, diabetes mellitus was also associated with prostate cancer‐specific mortality (hazard ratio = 1.26, 95% confidence interval = 1.20–1.33) and nonprostate cancer mortality (hazard ratio = 1.83, 95% confidence interval = 1.33–2.52) separately. There was no obvious publication bias amongst the studies included.ConclusionThe results of this meta‐analysis reveal an association of diabetes mellitus with adverse prognosis amongst those with prostate cancer. The biological basis of the association of diabetes mellitus with prostate cancer incidence and prognosis remains unclear. Doctors could pay more attention to prostate patients with pre‐existing diabetes mellitus, and more aggressive treatment regimens should be considered. Copyright © 2014 John Wiley & Sons, Ltd.
Serotonergic modulation of pain and analgesic responses: A study in rats with constitutionally altered serotonin transporters
Authors: Kesic M. , Tvrdeic A. , Kolaric D. , Stojkovic R. , Cicin‐Sain L. 
Published: July 2014

AbstractBackgroundA role of the serotonin (5HT) transporter, a key regulator of serotonergic transmission, in the physiology, pharmacology and genetics of pain responses has been proposed recently. The present study aimed to explore the impact of constitutive differences in the activity of the serotonin transporter, and 5HT homeostasis in general, on the modulation on pain sensitivity and analgesic responses to drugs that utilize 5HT mechanisms.MethodsA novel genetic animal model, Wistar‐Zagreb 5HT rats, obtained by selective breeding of animals for extreme activity of the platelet serotonin transporter was used. As a consequence of breeding, two sublines of this model, termed high‐5HT and low‐5HT, differ in both central and peripheral serotonin homeostasis. Thermal pain sensitivity of 5HT sublines was assessed at baseline and following administration of analgesic drugs, as determined by paw withdrawal latency to radiant heat stimulation.ResultsAnimals from 5HT sublines show differences in both basal pain sensitivity and analgesic responses. Rats with the low‐5HT phenotype displayed decreased baseline paw withdrawal latencies (hyperalgesia) in comparison to their high‐5HT counterpart (25%; p < 0.001). They also showed better analgesic response to acute and prolonged treatment with tramadol (p = 0.027) and clomipramine (p = 0.019), respectively, whereas administration of fluvoxamine did not produce an analgesic effect in either 5HT subline.ConclusionsThese findings support the idea that functionality of the serotonin transporter is one of the physiological/genetic determinants of individual differences in pain responses and modulation. They also validate Wistar‐Zagreb 5HT rats, with constitutionally up‐regulated/down‐regulated serotonin transporter, as a potential new genetic model for studying serotonergic modulation of pain responses.
A Parental Tool to Screen for Posttraumatic Stress in Children: First Psychometric Results
Authors: Verlinden Eva , van Laar Yvette L. , van Meijel Els P. M. , Opmeer Brent C. , Beer Renée , de Roos Carlijn , Bicanic Iva A. E. , Lamers‐Winkelman Francien , Olff Miranda , Boer Frits , Lindauer Ramón J. L. 
Published: July 2014

AbstractThe Children's Revised Impact of Event Scale (CRIES‐13) is a brief self‐report measure designed to screen children for posttraumatic stress disorder (PTSD). This study investigates the psychometric properties of a Dutch version of the CRIES‐13–parent version and evaluates its correlation with the child version. A sample of 59 trauma‐exposed children (8 years–18 years) and their parents completed an assessment including the CRIES‐13 (child/parent version) along with the Anxiety Disorders Interview Schedule for DSM‐IV: Parent version. Results demonstrated good internal consistency (α = .87) with acceptable values for the 3 subscales. A strong correlation (r = .73) with another measure of PTSD and lower correlations with a behavioral measure (r = .15 to .38) were found, confirming the convergent/divergent validity. A cutoff score ≥ 31 emerged as the best balance between sensitivity and specificity, and correctly classified 83.6% of all children as having a diagnosis of PTSD. This study provides support for the reliability and validity of the CRIES‐13–parent version as a screening measure for posttraumatic stress in children.
Transition‐Metal‐Catalyzed Chain‐Growth Polymerization of 1,4‐Diethynylbenzene into Microporous Crosslinked Poly(phenylacetylene)s: the Effect of Reaction Conditions
Authors: Slováková Eva , Zukal Arnošt , Brus Jiří , Balcar Hynek , Brabec Libor , Bondarev Dmitrij , Sedláček Jan 
Published: July 2014

Chain‐growth polymerization of 1,4‐diethynylbenzene into conjugated crosslinked polyacetylene‐type poly(1,4‐diethynylbenzene)s (PDEBs) is reported. While metathesis catalysts (WCl6/Ph4Sn, MoCl5/Ph4Sn, Mo Schrock carbene) fail in this polymerization, insertion Rh catalysts ([Rh(nbd)acac], [Rh(nbd)Cl]2) provide microporous PDEBs in high yields. The Brunauer–Emmett–Teller (BET) surface, SBET, of PDEBs prepared with [Rh(nbd)acac] increases, in dependence on the polymerization solvent, in the order: THF << pentane < benzene < methanol < CH2Cl2. SBET further increases with both increasing monomer concentration and increasing polymerization temperature and reaction time, reaching a highest value of 1469 m2 g−1. In addition to micropores, PDEBs contain mesopores. The mesopore volume and average mesopore diameter increase with the time and the temperature of the polymerization up to 2.52 cm3 g−1 and 22 nm (72 h, 75 °C). The post‐polymerization thermal treatment of PDEB (280 °C) results in formation of new crosslinks and modification of PDEB texture and sorption behavior manifested mainly by enhancement of H2 adsorption capacity up to 4.55 mmol g−1 (77 K, 750 Torr).
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Ion channel TRPM8 promotes hypoxic growth of prostate cancer cells via an O2‐independent and RACK1‐mediated mechanism of HIF‐1α stabilization
Authors: Yu Shan , Xu Zhenyu , Zou Chang , Wu Dinglan , Wang Yuliang , Yao Xiaoqiang , Ng Chi‐Fai , Chan Franky L 
Published: July 2014

AbstractThe growth adaptation of cancer cells to a hypoxic tumour microenvironment is mostly regulated by hypoxia‐induced transcription factor HIF‐1. HIF‐1 transcriptional activity is strictly controlled by protein levels of the HIF‐1α subunit, which is tightly regulated by a well‐characterized O2‐dependent ubiquitin ligase–proteasomal degradation pathway. The cold‐sensitive Ca2+ channel protein TRPM8 exhibits increased expression in advanced prostate cancer. However, its exact functional roles in prostate cancer growth regulation are unclear and controversial. In this work, we show that TRPM8 promotes in vitro hypoxic growth capacities, drug resistance, and in vivo tumourigenicity, accompanied with enhanced HIF‐1α protein levels. These effects are further potentiated by TRPM8 agonists but suppressed by TRPM8 gene knockdown and blocking with antagonists or TRPM8 antibody. TRPM8‐induced suppression of HIF‐1α ubiquitination and enhanced HIF‐1 transactivation were attenuated by forced RACK1 expression and TRPM8 overexpression reduced phospho‐RACK1 levels, thus affecting its dimerization status, and promoted RACK1 binding to HIF‐1α and calcineurin. These data indicate that TRPM8‐induced increase of HIF‐1α protein in hypoxia‐ or normoxia‐exposed prostate cancer cells was mediated through a newly characterized Ca2+‐dependent but O2‐independent mechanism involving binding of RACK1 to HIF‐1α and RACK1‐mediated ubiquitination of HIF‐1α. Collectively, our study not only provides a mechanistic insight into how TRPM8 promotes the hypoxic growth adaptation of cancer cells via its promotion of RACK1‐mediated stabilization of HIF‐1α but also suggests a potential therapeutic strategy for prostate cancer by targeting TRPM8.Copyright © 2014 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.
Synthesis, Characterization, and X‐ray Structures of Ru3(CO)9(dotpm)(L) Complexes [L = PPh3, P(C6H4Cl‐p)3, and PPh2(C6H4Br‐p)]
Authors: Sirat Siti Syaida , Khan Imthyaz Ahmed , Shawkataly Omar Bin , Rosli Mohd Mustaqim 
Published: July 2014

AbstractThe reaction of Ru3(CO)10(dotpm) (1) [dotpm = (bis(di‐ortho‐tolylphosphanyl)methane)] and one equivalent of L [L = PPh3, P(C6H4Cl‐p)3 and PPh2(C6H4Br‐p)] in refluxing n‐hexane afforded a series of derivatives [Ru3(CO)9(dotpm)L] (2–4), respectively, in ca. 67–70 % yield. Complexes 2–4 were characterized by elemental analysis (CHN), IR, 1H NMR, 13C{1H} NMR and 31P{1H} NMR spectroscopy. The molecular structures of 2, 3, and 4 were established by single‐crystal X‐ray diffraction. The bidentate dotpm and monodentate phosphine ligands occupy equatorial positions with respect to the Ru triangle. The effect of substitution resulted in significant differences in the Ru–Ru and Ru–P bond lengths.
213Bi-DOTATOC receptor-targeted alpha-radionuclide therapy induces remission in neuroendocrine tumours refractory to beta radiation: a first-in-human experience
Authors: Kratochwil C. , Giesel F. L. , Bruchertseifer F. , Mier W. , Apostolidis C. , Boll R. , Murphy K. , Haberkorn U. , Morgenstern A. 
Published: July 2014

Abstract

Purpose
Radiopeptide therapy using a somatostatin analogue labelled with a beta emitter such as 90Y/177Lu-DOTATOC is a new therapeutic option in neuroendocrine cancer. Alternative treatments for patients with refractory disease are rare. Here we report the first-in-human experience with 213Bi-DOTATOC targeted alpha therapy (TAT) in patients pretreated with beta emitters.

Methods
Seven patients with progressive advanced neuroendocrine liver metastases refractory to treatment with 90Y/177Lu-DOTATOC were treated with an intraarterial infusion of 213Bi-DOTATOC, and one patient with bone marrow carcinosis was treated with a systemic infusion of 213Bi-DOTATOC. Haematological, kidney and endocrine toxicities were assessed according to CTCAE criteria. Radiological response was assessed with contrast-enhanced MRI and 68Ga-DOTATOC-PET/CT. More than 2 years of follow-up were available in seven patients.

Results
The biodistribution of 213Bi-DOTATOC was evaluable with 440 keV gamma emission scans, and demonstrated specific tumour binding. Enduring responses were observed in all treated patients. Chronic kidney toxicity was moderate. Acute haematotoxicity was even less pronounced than with the preceding beta therapies.

Conclusion
TAT can induce remission of tumours refractory to beta radiation with favourable acute and mid-term toxicity at therapeutic effective doses.
Maternal antenatal anxiety, postnatal stroking and emotional problems in children: outcomes predicted from pre- and postnatal programming hypotheses
Authors: Sharp H. , Hill J. , Hellier J. , Pickles A. 
Published: July 2014

BackgroundMothers' self-reported stroking of their infants over the first weeks of life modifies the association between prenatal depression and physiological and emotional reactivity at 7 months, consistent with animal studies of the effects of tactile stimulation. We now investigate whether the effects of maternal stroking persist to 2.5 years. Given animal and human evidence for sex differences in the effects of prenatal stress we compare associations in boys and girls.MethodFrom a general population sample of 1233 first-time mothers recruited at 20 weeks gestation we drew a random sample of 316 for assessment at 32 weeks, stratified by reported inter-partner psychological abuse, a risk indicator for child development. Of these mothers, 243 reported at 5 and 9 weeks how often they stroked their infants, and completed the Child Behavior Checklist (CBCL) at 2.5 years post-delivery.ResultsThere was a significant interaction between prenatal anxiety and maternal stroking in the prediction of CBCL internalizing (p = 0.001) and anxious/depressed scores (p < 0.001). The effects were stronger in females than males, and the three-way interaction prenatal anxiety × maternal stroking × sex of infant was significant for internalizing symptoms (p = 0.003). The interactions arose from an association between prenatal anxiety and internalizing symptoms only in the presence of low maternal stroking.ConclusionsThe findings are consistent with stable epigenetic effects, many sex specific, reported in animal studies. While epigenetic mechanisms may be underlying the associations, it remains to be established whether stroking affects gene expression in humans.
Does Self-reporting Facilitate History Taking in Food Poisoning Mass-casualty Incidents?
Authors: Hsu Ya-I , Huang Ying C. 
Published: July 2014

AbstractIntroductionMedical history is an important contributor to diagnosis and patient management. In mass-casualty incidents (MCIs), health care providers are often overwhelmed by large numbers of casualties. An efficient, reliable, and affordable method of information collection is essential for effective health care response.Hypothesis/ProblemIn some MCIs, self-reporting of symptoms can decrease the time required for history taking, without sacrificing the completeness of triage information.MethodsTwo resident doctors and a number of seventh graders who had previous experience of abdominal discomfort were invited to join this study. A questionnaire was developed to collect information on common symptoms in food poisoning. Each question was scored, and enrolled students were randomly divided into two groups. The experimental group students answered the questionnaire first and then were interviewed to complete the medical history. The control group students were interviewed in the traditional way to collect medical history. Time of all interviews was measured and recorded. The time needed to complete the history taking and completeness of obtained information were compared with students’ttests, or Mann-Whitney U tests, based on the normality of data. Comprehensibility of each question, scored by enrolled students, was reported by descriptive statistics.ResultsThere were 41 students enrolled: 22 in the experimental group and 19 in the control group. Time to complete history taking in the experimental group (163.0 seconds, SD=52.3) was shorter than that in the control group (198.7 seconds, SD=40.9) (P=.010). There was no difference in the completeness of history obtained between the experimental group and the control group (94.8%, SD=5.0 vs 94.2%, SD=6.1;P=.747). Between the two doctors, no significant difference was found in the time required for history taking (185.2 seconds, SD=42.2 vs 173.1 seconds, SD=58.6;P=.449), or the completeness of information (94.1%, SD=5.9 vs 95.0%, SD=5.0;P=.601). Most of the questions were scored “good” in comprehensibility.ConclusionSelf-reporting of symptoms can shorten the time of history taking during a food poisoning mass-casualty event without sacrificing the completeness of information.HsuY,HuangYC.Does self-reporting facilitate history taking in food poisoning mass-casualty incidents?Prehosp Disaster Med.2014;29(4):1-4.
Rule Monitoring Ability Predicts Event-Based Prospective Memory Performance in Individuals with TBI
Authors: Paxton Jessica , Chiaravalloti Nancy 
Published: July 2014

AbstractNumerous studies have demonstrated that prospective memory (PM) abilities are impaired following traumatic brain injury (TBI). PM refers to the ability to remember to complete a planned action following a delay. PM post-TBI has been shown to be related to performance on neuropsychological tests of executive functioning and retrospective episodic memory (RM). However, the relative influence of impairments in RM versus executive functioning on PM performance post-TBI remains uninvestigated. In the current study, PM and neuropsychological test performance were examined in 45 persons with a history of moderate to severe TBI at least 1 year before enrollment. Regression analyses examined the relative contributions of RM and executive functioning in the prediction of PM performance on the Rivermead Behavioral Memory Test (RBMT). Results indicated that scores on tests of delayed RM and rule monitoring (i.e., ability to avoid making errors on executive measures) were the strongest predictors of PM. When the interaction between RM impairment and rule monitoring was examined, a positive relationship between PM and rule monitoring was found only in TBI participants with impaired RM. Results suggest that PM performance is dependent upon rule monitoring abilities only when RM is impaired following TBI. (JINS, 2014, 20, 1–11)