bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual presentation of tuberculosis in an elderly male: a case report
Authors: Kandel Ramesh , Bhattarai Bhawana , Maharjan Santosh 
Published: November 2014

Key Clinical MessageTuberculous liver abscess is an extremely rare condition, even in tuberculosis endemic countries. A 68‐year‐old male presented with 2 months of fever, significant weight loss, and hepatomegaly. Ultrasonography revealed a right hepatic lobe abscess. Guided aspiration of the fluid showed tubercular bacilli. He had no evidence of active Tuberculosis elsewhere.
Paired Electrosynthesis of Diacid and Diol Precursors Using Dienes and CO2 as the Carbon Source
Authors: Matthessen Roman , Fransaer Jan , Binnemans Koen , De Vos Dirk E. 
Published: November 2014

AbstractA new electrochemical methodology was devised and optimized, allowing a net incorporation of carbon dioxide in conjugated dienes in a one‐compartment cell using a non‐sacrificial anode. This divergent paired electrosynthesis of diacid and diol precursors was achieved through simultaneous cathodic carboxylation and anodic acetoxylation of conjugated dienes. After optimization of the reaction conditions, 1,3‐cyclohexadiene was converted to its corresponding 1,4‐dicarboxylate salt and 1,4‐diacetate ester with high yields and current efficiencies. A large effect of alkyl substitution and molecular configuration on the reactivity of conjugated double bonds towards carboxylation and acetoxylation was observed.
Anaerobic co‐digestion of dairy cattle slurry and agro‐industrial fats: Effect of fat ratio on the digester efficiency
Authors: Guillaume Sébastien , Lendormi Thomas 
Published: November 2014

AbstractThe objective of the study was to optimize the co‐digestion of cattle slurry in the presence of fats from the food industry. A laboratory pilot plant operating continuously was used for the experimental study. Tests were carried out with only cattle slurry and with different fat ratio (0, 10, 25, 45 and 60 %w/w of the feed COD as fats). In the case of using cattle slurry feed and OLR from 0.4 and 3.0 kg VS · m−3 · day−1 (HRT between 125 days and 19 days), methane productivity versus OLR exhibit a linear relation reflecting optimum biodegradability of the organic matter. For OLR above 3 kg VS · m−3 · day−1 (HRT less than 19 days), a break in the slope is observed expressing a decrease of the organic matter degradation rate. For HRT equal to 30 days, the results show that fat incorporation ratio lower than 25 %w/w does not affect the digester operation while maintaining acceptable biodegradability of the fat. In contrast, with a fat ratio of 60 %w/w, the system became unstable and a significant decrease in the methane productivity was observed, due to an accumulation of undegraded Long Chain Fatty Acids (LCFA). The conclusion is that the fat ratio must be controlled to avoid the destabilization of digestion, and finally operational conditions are proposed for co‐digestion.
Towards the modelling of a heat‐exchanger reactor by a dynamic approach
Authors: Marin Gallego Juan Carlos , Olivier‐Maget Nelly , Hetreux Gilles , Gabas Nadine , Cabassud Michel 
Published: November 2014

AbstractThe aim of this paper is to present the development of a simulation tool in order to assess the inherently safe characteristics of a heat‐exchanger reactor (HEX) operating reaction systems. The modelling of steady and transient states of a HEX reactor is performed following a hybrid dynamic approach. The global dynamic behaviour of this reactor can be represented by several continuous models, which are bounded by state or time events. Each continuous model is defined as a system of partial differential‐algebraic equations. The numerical scheme is based on the method of lines. Special attention is paid to the model initialization and a simulation strategy of the start‐up phase is presented. The validation of the model is made by numerous examples, such as the simulation of an exothermic reaction.
A mixed‐methods examination of communication between oncologists and primary care providers among primary care physicians in underserved communities
Authors: Shen Megan Johnson , Binz‐Scharf Maria , D'Agostino Tom , Blakeney Natasha , Weiss Elisa , Michaels Margo , Patel Shilpa , McKee M. Diane , Bylund Carma L. 
Published: November 2014

BACKGROUNDResearch has demonstrated that communication and care coordination improve cancer patient outcomes. To improve communication and care coordination, it is important to understand primary care providers' (PCPs') perceptions of communication with oncologists as well as PCPs' communication needs.METHODSA mixed‐methods approach was used in the present study. In the qualitative phase of the study, 18 PCPs practicing in underserved, minority communities were interviewed about their experiences communicating with oncologists. In the quantitative phase of the study, 128 PCPs completed an online survey about their preferences, experiences, and satisfaction with communication with oncologists.RESULTSResults indicated a PCP‐oncologist gap in communication occurred between diagnosis and treatment. PCPs wanted more communication with oncologists, updates on their patients' prognosis throughout treatment, and to be contacted via telephone or email and saw their role as crucial in providing supportive care for their patients.CONCLUSIONSAlthough PCPs recognize that they play a critical, proactive role in supporting patients throughout the continuum of their cancer care experience, existing norms regarding postreferral engagement and oncologist‐PCP communication often hinder activation of this role among PCPs. Expected standards regarding the method, frequency, and quality of postreferral communication should be jointly articulated and made accountable between PCPs and oncologists to help improve cancer patients' quality of care, particularly in minority communities. Cancer 2015;121:908–915. © 2014 American Cancer Society.
Analysis of accessing to the nearest and to the strongest base station in femtocell networks
Authors: Zhang Huanle , Liu Jian , Shi Haili 
Published: November 2014

SummaryThe deployment of femtocells can effectively improve the capacity of cellular networks without significant increase in the network management costs. Femtocell base stations are usually installed by users, which poses unique challenges for future mobile communication standards. The randomness of the locations of femtocells brings us many difficulties to analyze and compare. In this paper, we explore the performance on two different access methods under Rayleigh fading channel: accessing to the nearest and accessing to the strongest femtocell base station. Two performance indexes are of most interest in this paper: how the different path loss exponents and femtocell densities affect the difference of performance between the two different access methods. In the first part of this paper, the distributions of received strength for both access methods are achieved, in which we elaborate the characteristics of received signal strength including the cumulative distribution and the median signal strength. In the second part, we explore the characteristic of SINR distribution, which can be interpreted as the probability of coverage. This paper provides detailed illustrations about how performance changes for these two different access methods under Rayleigh fading channel. All results are mathematically tractable. Copyright © 2014 John Wiley & Sons, Ltd.
Cooperative wireless localization based on weighting for vector‐addition error
Authors: Cui Qimei , Shi Yulong , Zhang Xuefei , Tao Xiaofeng 
Published: November 2014

SummaryLocalization error occurrence due to a position ambiguity is a very critical problem in wireless distributed cooperative localization, which may, in turn, affect the reliability of the localization of the whole or a major portion of the network. In this paper, we formulate a two‐dimensional cooperative localization model via graph partition in arbitrary topologies while considering the cooperative node's (or neighbor's) position ambiguity. Based on this model, we establish a robust algorithm, named weighted factor graph (FG)‐based cooperative localization algorithm, by mapping local topologies into the FG and by incorporating the vector‐addition error as the weight. The vector‐addition error includes the measurement error and the neighbor's position ambiguity, simultaneously. The optimal weight is derived theoretically according to the statistic properties of the vector errors and the joint probability density function. Theoretical analysis and numerical results indicate that the proposed algorithm can acquire higher level of accuracy for localization in various topology scenarios in comparison with some typical algorithms. Copyright © 2014 John Wiley & Sons, Ltd.
Development of the innervation of the human inner ear
Authors: Pechriggl Elisabeth J. , Bitsche Mario , Glueckert Rudolf , Rask‐Andersen Helge , Blumer Michael J. F. , Schrott‐Fischer Annelies , Fritsch Helga 
Published: November 2014

ABSTRACTStudies on the formation of neuronal structures of the human cochlea are rare, presumptively, due to the difficult accessibility of specimens, so that most investigations are performed on mouse models. By means of immunohistochemical and transmission electron microscopic techniques, we investigated an uninterrupted series of unique specimens from gestational week 8 to week 12. We were able to demonstrate the presence of nerve fibers in the prosensory domain at gestational week 8, followed by afferent synaptogenesis at week 11. We identified PAX2 as an early marker for hair cell differentiation. Glutamine synthetase‐positive peripheral glial cells occurred at the beginning of week 8. Transcription factor MAF B was used to demonstrate maturation of the spiral ganglion neurons. The early expression of tyrosine hydroxylase could be assessed. This study provides insights in the early assembly of the neural circuit and organization in humans. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 683–702, 2015
Two new targeted alleles for the comprehensive analysis of Meis1 functions in the mouse
Authors: González‐Lázaro Mónica , Roselló‐Díez Alberto , Delgado Irene , Carramolino Laura , Sanguino María Angeles , Giovinazzo Giovanna , Torres Miguel 
Published: November 2014

SummaryMeis1 is a highly conserved transcription factor that is activated in a regionally restricted manner from early stages of development. Meis1 belongs to the three amino acid loop extension (TALE) homeodomain family. Together with Pbx1, Meis1 plays a major role as a Hox cofactor, and therefore, plays an essential role in the development of several embryonic organs and systems, including limbs, heart, blood, and vasculature. In addition, Meis1 is required for the development of Hox‐free embryonic regions and interacts with non‐Hox homeodomain and non‐homeodomain transcription factors. During post‐natal life Meis1 is involved in adult cardiomyocyte homeostasis and has been associated with pre‐disposition to human neural and cardiac pathologies. Given the relevance of this transcription factor, we have developed two new Meis1 gene knockin models; a direct ECFP knockin insertion that allows the direct identification of Meis1‐expressing cells in living tissues, and a CreERT2 insertion that allows the inducible genetic tracing of Meis1‐expressing cells in a time‐controlled manner. Importantly, these two alleles represent the first Meis1 mutations in which Meis1 protein production is completely eliminated. These newly targeted Meis1 alleles will be valuable tools to further our understanding of the role of this critical transcription factor during development and disease. genesis 52:967–975, 2014. © 2014 Wiley Periodicals, Inc.
Bioaccumulation of metals and metalloids in medicinal plant Ipomoea pes-caprae from areas impacted by tsunami
Authors: Kozak Lidia , Kokociński Mikołaj , Niedzielski Przemysław , Lorenc Stanisław 
Published: November 2014

Abstract

Tsunami events may have an enormous impact on the functioning of aquatic and terrestrial ecosystems by altering various relationships with biotic components. Concentrations of acid-leachable fractions of heavy metals and metalloids in soils and plant samples from areas affected by the December 2004 tsunami in Thailand were determined. Ipomoea pes-caprae, a common plant species growing along the seashore of this region, and frequently used in folk medicine, was selected to assess the presence of selected elements. Elevated amounts of Cd, Pb, Zn, and As in soil samples, and Pb, Zn, As, Se, Cr, and Ni in plant samples were determined from the tsunami-impacted regions for comparison with reference locations. The flowers of Ipomoea pes-caprae contained the highest amounts of these metals, followed by its leaves, and stems. In addition, its bioaccumulation factor (BAF) supports this capability of high metal uptake by Ipomoea pes-caprae from the areas affected by the tsunami in comparison with a reference site. This uptake was followed by the translocation of these elements to the various plant components. The presence of these toxic metals in Ipomoea pes-caprae growing in contaminated soils should be a concern of those who use this plant for medicinal purposes. Further studies on the content of heavy metals and metalloids in this plant in relation to human health concerns are recommended. Environ Toxicol Chem 2014;9999:1–6. © 2014 SETAC
Environmental fate of emamectin benzoate after tree micro injection of horse chestnut trees
Authors: Burkhard Rene , Binz Heinz , Roux Christian A. , Brunner Matthias , Ruesch Othmar , Wyss Peter 
Published: November 2014

Abstract

Emamectin benzoate, an insecticide derived from the avermectin family of natural products, has a unique translocation behavior in trees when applied by tree micro injection (TMI), which can result in protection from insect pests (foliar and borers) for several years. Active ingredient imported into leaves was measured at the end of season in the fallen leaves of treated horse chestnut (Aesculus hippocastanum) trees. The dissipation of emamectin benzoate in these leaves seems to be biphasic and depends on the decomposition of the leaf. In compost piles, where decomposition of leaves was fastest, a cumulative emamectin benzoate degradation half-life time of 20 d was measured. In leaves immersed in water, where decomposition was much slower, the degradation half-life time was 94 d, and in leaves left on the ground in contact with soil, where decomposition was slowest, the degradation half-life time was 212 d. The biphasic decline and the correlation with leaf decomposition might be attributed to an extensive sorption of emamectin benzoate residues to leaf macromolecules. This may also explain why earthworms ingesting leaves from injected trees take up very little emamectin benzoate and excrete it with the feces. Furthermore, no emamectin benzoate was found in water containing decomposing leaves from injected trees. It is concluded, that emamectin benzoate present in abscised leaves from horse chestnut trees injected with the insecticide is not available to nontarget organisms present in soil or water bodies. Environ Toxicol Chem 2014;9999:1–6. © 2014 The Authors. Published 2014 SETAC
Sex differences in cognitive regulation of psychosocial achievement stress: Brain and behavior
Authors: Kogler Lydia , Gur Ruben C. , Derntl Birgit 
Published: November 2014

AbstractAlthough cognitive regulation of emotion has been extensively examined, there is a lack of studies assessing cognitive regulation in stressful achievement situations. This study used functional magnetic resonance imaging in 23 females and 20 males to investigate cognitive downregulation of negative, stressful sensations during a frequently used psychosocial stress task. Additionally, subjective responses, cognitive regulation strategies, salivary cortisol, and skin conductance response were assessed. Subjective response supported the experimental manipulation by showing higher anger and negative affect ratings after stress regulation than after the mere exposure to stress. On a neural level, right middle frontal gyrus (MFG) and right superior temporal gyrus (STG) were more strongly activated during regulation than nonregulation, whereas the hippocampus was less activated during regulation. Sex differences were evident: after regulation females expressed higher subjective stress ratings than males, and these ratings were associated with right hippocampal activation. In the nonregulation block, females showed greater activation of the left amygdala and the right STG during stress than males while males recruited the putamen more robustly in this condition. Thus, cognitive regulation of stressful achievement situations seems to induce additional stress, to recruit regions implicated in attention integration and working memory and to deactivate memory retrieval. Stress itself is associated with greater activation of limbic as well as attention areas in females than males. Additionally, activation of the memory system during cognitive regulation of stress is associated with greater perceived stress in females. Sex differences in cognitive regulation strategies merit further investigation that can guide sex sensitive interventions for stress‐associated disorders. Hum Brain Mapp 36:1028–1042, 2015. © 2014 Wiley Periodicals, Inc.
The Relationship between Coworker Incivility, Emotional Exhaustion, and Organizational Outcomes: The Mediating Role of Emotional Exhaustion
Authors: Hur Won‐Moo , Kim Byung‐Soo , Park Sung‐Jae 
Published: November 2014

AbstractThe aim of this research is to investigate the relationship between coworker incivility, emotional exhaustion, and organizational outcomes measured by job satisfaction, job performance, and turnover intention. Working with a sample of 286 retail bank employees in South Korea, structural equation modeling is employed to test four hypotheses drawing on conservation of resources (COR) theory and affective events theory (AET). According to the analyses, while employee incivility positively affects emotional exhaustion, emotional exhaustion has a negative effect on job satisfaction and job performance. In addition, emotional exhaustion has a positive impact on turnover intention among organizational employees. These results imply that to better understand the relationship between coworker incivility and organizational outcomes, it is necessary to consider emotional exhaustion as an important mediating variable. The theoretical and practical implications of this study are discussed, together with its limitations and future research directions.
Lenz-Majewski Hyperostotic Dwarfism with Hyperphosphoserinuria from a Novel Mutation in PTDSS1 Encoding Phosphatidylserine Synthase 1
Authors: Whyte Michael P , Blythe Amanda , McAlister William H , Nenninger Angela R , Bijanki Vinieth N , Mumm Steven 
Published: November 2014

ABSTRACT

Lenz-Majewski hyperostotic dwarfism (LMHD) is an ultra-rare Mendelian craniotubular dysostosis that causes skeletal dysmorphism and widely distributed osteosclerosis. Biochemical and histopathological characterization of the bone disease is incomplete and nonexistent, respectively. In 2014, a publication concerning five unrelated patients with LMHD disclosed that all carried one of three heterozygous missense mutations in PTDSS1 encoding phosphatidylserine synthase 1 (PSS1). PSS1 promotes the biosynthesis of phosphatidylserine (PTDS), which is a functional constituent of lipid bilayers. In vitro, these PTDSS1 mutations were gain-of-function and increased PTDS production. Notably, PTDS binds calcium within matrix vesicles to engender hydroxyapatite crystal formation, and may enhance mesenchymal stem cell differentiation leading to osteogenesis. We report an infant girl with LMHD and a novel heterozygous missense mutation (c.829T&gt;C, p.Trp277Arg) within PTDSS1. Bone turnover markers suggested that her osteosclerosis resulted from accelerated formation with an unremarkable rate of resorption. Urinary amino acid quantitation revealed a greater than sixfold elevation of phosphoserine. Our findings affirm that PTDSS1 defects cause LMHD and support enhanced biosynthesis of PTDS in the pathogenesis of LMHD. © 2014 American Society for Bone and Mineral Research.
A possible link between wildfire aerosol and North American Monsoon precipitation in Arizona–New Mexico
Authors: McKendry Ian G. , Gutzler David S. 
Published: November 2014

ABSTRACTPrevious research highlights the dominant role of Pacific sea surface temperatures (SSTs) and their associated large‐scale teleconnections in modulating the North American monsoon (NAM). At the regional scale, feedbacks associated with land‐surface boundary conditions have been shown to provide ‘memory’ in the system. Here, a previously unexplored second‐order linkage between aerosol generated by late‐spring wildfires and subsequent summer precipitation delivered by the NAM in the Arizona‐New Mexico (AZNM) region is proposed. Correlations between June/July organic carbon and elemental carbon (OC/EC) in Inter‐agency Monitoring of Protected Visual Environments (IMPROVE) aerosol data (Gila Wilderness and Bandelier) and NAM precipitation in southern AZNM over the period 1994–2012 are shown to be negative (r = –0.4), suggesting that active antecedent wildfire seasons tend to be immediately followed by a weak late summer monsoon. This result is consistent with a previous study linking precipitation and area burned in wildfires in AZNM. A survey of extant literature suggests a sound basis for potential mechanisms related to convective processes and cloud microphysics, and furthermore suggests that this forcing could be of similar magnitude to well‐documented land‐based second‐order NAM forcings (antecedent snowpack and soil moisture, vegetation, and mineral dust). Based on these results, we believe that the role of aerosols in modulating summer precipitation deserves further investigation both observationally and in modeling studies. If indeed wildfire smoke does contribute to the modulation of NAM intensity, by virtue of its close temporal association with NAM season, it may well represent a factor that could contribute effectively to improved seasonal prediction of summer precipitation in the NAM region.