bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal vitamin A and D status in second and third trimester of pregnancy and bone mineral content in offspring at nine years of age
Authors: Stunes Astrid Kamilla , Mosti Mats Peder , Gustafsson Miriam Katarina , Børsting Torunn , Thorsby Per Medbøe , Stafne Signe Nilssen , Syversen Unni 
Published: June 2024

IntroductionMaternal nutritional and vitamin status during pregnancy may have long-term effects on offspring health and disease. The aim of this study was to examine the associations between maternal vitamin A and D status in pregnancy and offspring bone mineral content (BMC) at nine years of age.MethodsThis is a post-hoc study of a randomized control trial including 855 pregnant women from two Norwegian cities; Trondheim and Stavanger. The women were randomized into an exercise intervention or standard antenatal care. Mother and child pairs for the present study were recruited from those still living in Trondheim after 8–10 years. Serum vitamin A (retinol) and vitamin D (25(OH)D) were measured in the 2nd and 3rd trimesters of pregnancy, and active vitamin D (1,25(OH)2D) in serum was measured in a subgroup. Spine BMC and trabecular bone score were measured in the children at nine years of age. Associations were analyzed with linear regression models.ResultsA total of 119 mother and child pairs were included in the analyses. Vitamin A insufficiency (retinol&lt; 1.05 µmol/L) and vitamin D deficiency (25(OH)D&lt; 50 mmol/L) increased from ~7% to ~43% and from ~28% to ~33%, respectively, from the 2nd to the 3rd trimester. An increase in serum 1,25(OH)2D from the 2nd to the 3rd trimester was observed in the subgroup. There was a negative association between serum retinol in the 2nd trimester and spine BMC in the boys, but not in the girls, when adjusted for maternal and child confounders. No other associations between maternal serum vitamin A or D and BMC in the children were found.ConclusionWe observed a high prevalence of vitamin A insufficiency and vitamin D deficiency during pregnancy. A negative association between mid-pregnancy vitamin A status and spine BMC was observed in boys, but not girls, while no associations were found between maternal vitamin D status and child BMC. The implications of optimal vitamin A and D status in pregnancy for offspring bone health, remains a subject for further investigations.
Training immunophenotyping deep learning models with the same-section ground truth cell label derivation method improves virtual staining accuracy
Authors: Azam Abu Bakr , Wee Felicia , Väyrynen Juha P. , Yim Willa Wen-You , Xue Yue Zhen , Chua Bok Leong , Lim Jeffrey Chun Tatt , Somasundaram Aditya Chidambaram , Tan Daniel Shao Weng , Takano Angela , Chow Chun Yuen , Khor Li Yan , Lim Tony Kiat Hon , Yeong Joe , Lau Mai Chan , Cai Yiyu 
Published: June 2024

IntroductionDeep learning (DL) models predicting biomarker expression in images of hematoxylin and eosin (H&amp;E)-stained tissues can improve access to multi-marker immunophenotyping, crucial for therapeutic monitoring, biomarker discovery, and personalized treatment development. Conventionally, these models are trained on ground truth cell labels derived from IHC-stained tissue sections adjacent to H&amp;E-stained ones, which might be less accurate than labels from the same section. Although many such DL models have been developed, the impact of ground truth cell label derivation methods on their performance has not been studied.MethodologyIn this study, we assess the impact of cell label derivation on H&amp;E model performance, with CD3+ T-cells in lung cancer tissues as a proof-of-concept. We compare two Pix2Pix generative adversarial network (P2P-GAN)-based virtual staining models: one trained with cell labels obtained from the same tissue section as the H&amp;E-stained section (the ‘same-section’ model) and one trained on cell labels from an adjacent tissue section (the ‘serial-section’ model).ResultsWe show that the same-section model exhibited significantly improved prediction performance compared to the ‘serial-section’ model. Furthermore, the same-section model outperformed the serial-section model in stratifying lung cancer patients within a public lung cancer cohort based on survival outcomes, demonstrating its potential clinical utility.DiscussionCollectively, our findings suggest that employing ground truth cell labels obtained through the same-section approach boosts immunophenotyping DL solutions.
Compliance with the breakthrough cancer pain European guidelines and impact on patients' quality of life: an observational prospective study
Authors: Bossi Paolo , Pietrzyńska Tatiana , Margarit Ferri César , Mansilla Irene , Tellone Valeria , Fioravanti Sara , Di Loreto Giorgio , Comandini Alessandro 
Published: June 2024

IntroductionThis study aimed to assess the percentage of patients treated according to the European Society for Medical Oncology (ESMO) 2018 guidelines for breakthrough cancer pain (BTcP) and the impact of guidelines adherence on patients' quality of life (QoL).MethodsAdult opioid-tolerant patients diagnosed with BTcP and locally advanced or recurrent metastatic cancer with a life expectancy of &gt;3 months prospectively were included. Patients were followed up for 28 days.ResultsOf 127 patients included, 37 were excluded due to the impossibility to establish adherence to the ESMO guidelines. Among the evaluable patients [51.1% female; with mean (SD) age of 66.4 (11.8) years], all were adherent. BTcP was diagnosed by the Association for Palliative Medicine algorithm in 47.8% of patients and by clinical experience in 52.2% of patients. The mean number of daily BTcP episodes ranged between 1 and 8, with a mean (95% CI) severity of 7.3 (7.0; 7.6) at week 0 and 6.2 (5.8; 6.6) at week 4. Time to maximum pain intensity was 3–15 min in 52.2% of patients, and BTcP lasted 30–60 min in 14.4% of patients at week 0 and 4.4% of patients at week 4. Mean (95% CI) treatment effectiveness was 6.6 (6.1; 7.1) at week 0 and 7.4 (7.0; 7.8) at week 4. Median (Q1–Q3) patients' global impression of clinical condition was 4.0 (4.0–4.0) at week 0 and 3.0 (2.0–3.0) at week 4.ConclusionA clear BTcP assessment and strict follow-up could be crucial to guidelines adherence and for patient's QoL.
Sugemalimab combined with chemotherapy for the treatment of advanced esophageal squamous cell carcinoma: a cost-effectiveness analysis
Authors: Cai Hongfu , Fang Ling , Zheng Zhiwei 
Published: June 2024

BackgroundThis study aims to systematically analyze the cost-effectiveness of the combination therapy comprising sugemalimab and chemotherapy in the management of advanced ESCC from the Chinese healthcare system perspective.MethodsAn advanced ESCC patient simulation partitioned survival approach model was developed to mimic the disease progression of patients undergoing treatment with sugemalimab in combination with chemotherapy versus chemotherapy alone. To ensure accuracy and precision, clinical data, treatment costs, and utility values were collected from comprehensive clinical trials and reliable economic databases. The cost-effectiveness analysis was conducted by assessing the incremental cost-effectiveness ratio in relation to the established willingness-to-pay threshold. One-way and probabilistic sensitivity analyses were performed to assess the robustness of the model.ResultsThe cumulative expenditure for the group of patients administered with sugemalimab amounted to US$ 41734.87, whereas the placebo group was associated with a total cost of US$ 22926.25. By evaluating the ICER, which quantifies the additional cost incurred per QALY gained, a value of US$ 61066.96 per QALY was determined. It is imperative to note that this ICER value surpasses the predetermined threshold for WTP in China, set at US$ 39,855.79 per QALY. Sensitivity analyses demonstrated that the results were sensitive to the cost of sugemalimab, progression-free survival, and utility values. These fluctuations did not result in a reversal of the study findings.ConclusionThe combination of sugemalimab with chemotherapy for the treatment of ESCC in China is currently not considered a cost-effective therapeutic approach. However, it is suggested that additional reductions in price may facilitate the potential for achieving cost-effectiveness.
How to discriminate wood of CITES-listed tree species from their look-alikes: using an attention mechanism with the ResNet model on an enhanced macroscopic image dataset
Authors: Liu Shoujia , Zheng Chang , Wang Jiajun , Lu Yang , Yao Jie , Zou Zhiyuan , Yin Yafang , He Tuo 
Published: June 2024

IntroductionGlobal illegal trade in timbers is a major cause of the loss of tree species diversity. The Convention on International Trade in Endangered Species of Wild Fauna and Flora (CITES) has been developed to combat the illegal international timber trade. Its implementation relies on accurate wood identification techniques for field screening. However, meeting the demand for timber field screening at the species level using the traditional wood identification method depending on wood anatomy is complicated, time-consuming, and challenging for enforcement officials who did not major in wood science.MethodsThis study constructed a CITES-28 macroscopic image dataset, including 9,437 original images of 279 xylarium wood specimens from 14 CITES-listed commonly traded tree species and 14 look-alike species. We evaluated a suitable wood image preprocessing method and developed a highly effective computer vision classification model, SE-ResNet, on the enhanced image dataset. The model incorporated attention mechanism modules [squeeze-and-excitation networks (SENet)] into a convolutional neural network (ResNet) to identify 28 wood species.ResultsThe results showed that the SE-ResNet model achieved a remarkable 99.65% accuracy. Additionally, image cropping and rotation were proven effective image preprocessing methods for data enhancement. This study also conducted real-world identification using images of new specimens from the timber market to test the model and achieved 82.3% accuracy.ConclusionThis study presents a convolutional neural network model coupled with the SENet module to discriminate CITES-listed species with their look-alikes and investigates a standard guideline for enhancing wood transverse image data, providing a practical computer vision method tool to protect endangered tree species and highlighting its substantial potential for CITES implementation.
Group based metacognitive therapy for alcohol use disorder: a pilot study
Authors: Kroener Julia , Eickholt Maja Lara , Sosic-Vasic Zrinka 
Published: June 2024

IntroductionAlcohol use disorder (AUD) is a severe clinical disorder, which has been associated with 5.3% of death worldwide. Although several treatments have been developed to improve AUD symptomatology, treatment effects were moderate, with a certain amount of patients displaying symptom deterioration after treatment termination. Moreover, outpatient treatment placements become increasingly scarce, thus necessitating more efficient treatment options. Therefore, the aim of the present study was to investigate the efficacy, feasibility, and acceptability of a newly invented, short, group based metacognitive therapy (MCT) for patients diagnosed with AUD.MethodSeven patients were treated with eight sessions of group based MCT using a single case series design with an A-B replication across patients. Patients were assessed one month and one week before treatment, as well as one week and three months after treatment termination. ResultsPatients improved significantly and with large effect sizes regarding dysfunctional metacognitive beliefs, desire thinking/craving and depressive symptoms up to three months after treatment termination. AUD symptomatology as well as positive and negative metacognitive beliefs improved at post-treatment, but improvements could not be maintained at follow-up. All included patients completed the treatment and were highly satisfied. ConclusionThe presented findings show preliminary evidence for the efficacy, feasibility, and acceptability of the implemented group based MCT treatment. Large scale randomized controlled trials (RCTs) are needed to confirm the effectiveness of the developed program for patients diagnosed with AUD.
Cure for tantrums? Longitudinal associations between parental digital emotion regulation and children's self-regulatory skills
Authors: Konok V. , Binet M.-A. , Korom Á. , Pogány Á. , Miklósi Á. , Fitzpatrick C. 
Published: June 2024

IntroductionParents often use digital devices to regulate their children's negative emotions, e.g., to stop tantrums. However, this could hinder child development of self-regulatory skills. The objective of the study was to observe bidirectional longitudinal associations between parents' reliance on digital devices to regulate their child's emotions and self-regulatory tendencies (anger/frustration management, effortful control, impulsivity).MethodsParents (N = 265) filled out the Child Behavior Questionnaire—Short Form and the Media Assessment Questionnaire twice: the initial assessment (T1) took place in 2020 (mean child age = 3.5 years old), and follow-up (T2) occurred a year later in 2021 (mean child age = 4.5 years old).ResultsHigher occurrence of parental digital emotion regulation (PDER) in T1 predicts higher anger and lower effortful control in T2, but not impulsivity. Higher anger in T1, but not impulsivity and effortful control, predicts higher PDER in T2.DiscussionOur results suggest that parents of children with greater temperament-based anger use digital devices to regulate the child's emotions (e.g., anger). However, this strategy hinders development of self-regulatory skills, leading to poorer effortful control and anger management in the child.
Multiplex influences on vigilance and biochemical variables induced by sleep deprivation
Authors: Liu Shiqi , Ma Xiaohong , Chen Ying , Zhao Yuanyuan , Luo Rujia , Wu Zhouying , Li Yicheng , Qian Yongyu , Wang Wenwen , Dong Shuohan , Zhou Zengxuan , Li Silin , Xiao Yi , Zhu Xinhai , Tian Yu , Guo Jinhu 
Published: June 2024

IntroductionSleep loss and sleep deprivation (SD) cause deleterious influences on health, cognition, mood and behaviour. Nevertheless, insufficient sleep and SD are prevalent across many industries and occur in various emergencies. The deleterious consequences of SD have yet to be fully elucidated. This study aimed to assess the extensive influences of SD on physiology, vigilance, and plasma biochemical variables.MethodsSeventeen volunteers were recruited to participate in a 32.5-h SD experiment. Multiple physiological and cognitive variables, including tympanic temperature, blood oxygen saturation (SaO2), and vigilance were recorded. Urinal/salivary samples were collected and subjected to cortisol or cortisone analysis, and plasma samples were subjected to transcriptomic analysis of circular RNA (circRNA) expression using microarray. Plasma neurotransmitters were measured by targeted metabolic analysis, and the levels of inflammatory factors were assessed by antibody microarray.ResultsThe volunteers showed significantly increased sleepiness and decreased vigilance during SD, and the changes in circadian rhythm and plasma biochemistry were observed. The plasma calcium (p = 0.0007) was induced by SD, while ischaemia-modified albumin (IMA, p = 0.0030) and total bile acid (TBA, p = 0.0157) decreased. Differentially expressed circRNAs in plasma were identified, which are involved in multiple signaling pathways including neuronal regulation and immunity. Accordingly, SD induced a decrease in 3-hydroxybutyric acid (3OBH, p = 0.0002) and an increase in thyroxine (T4, p &lt; 0.0001) in plasma. The plasma anti-inflammatory cytokine IL-10 was downregulated while other ten inflammatory factors were upregulated.ConclusionThis study demonstrates that SD influences biochemical, physiological, cognitive variables, and the significantly changed variables may serve as candidates of SD markers. These findings may further our understanding of the detrimental consequence of sleep disturbance at multiple levels.
PHÁT HIỆN VÙNG BẤT THƯỜNG TRÊN ẢNH MRI NÃO VỚI MÔ HÌNH SWIN-UNET
Authors: Lợi Lê Minh , Thư Trần Nguyễn Minh , An Hồ Quốc , Khang Phạm Nguyên 
Published: June 2024

Để xác định vùng bất thường trên ảnh MRI sọ não, bác sĩ chẩn đoán hình ảnh cần khảo sát nhiều lát cắt từ bộ ảnh. Nghiên cứu này giúp tự động phát hiện vùng bất thường của não trên ảnh MRI. Các mô hình Unet, ResNet, Swin-Unet được huấn luyện trên bộ dữ liệu của Bệnh viện Trường Đại học Y Dược Cần Thơ kết hợp bộ dữ liệu LGG để phân đoạn ảnh có hoặc không có vùng bất thường. Sau đó mô hình sẽ đề xuất vùng bất thường thông qua đường biên được vẽ xung quanh. Kết quả thực nghiệm cho thấy, khi chia dữ liệu ngẫu nhiên theo ảnh, mô hình Swin-Unet đạt được độ chính xác cao nhất là 0,88, cùng với Recall, Precision và F1 Score lần lượt là 0,96, 0,71, và 0,82. Đối với việc xác định vị trí và hình dạng của vùng bất thường, Swin-Unet cũng thể hiện hiệu suất cao với mIoU đạt 0,89 và mDSC là 0,91. Khi chia dữ liệu theo bệnh nhân, mô hình Swin-Unet lại một lần nữa thể hiện hiệu suất tốt với độ chính xác (Accuracy) đạt 0,86, cùng với Recall là 0,88, Precision là 0,79, F1 Score là 0,83, còn đối với mIoU đạt 0,84 và mDSC đạt 0,89. Kết quả nghiên cứu cho thấy mô hình Swin-Unet có kết quả tốt trong bài toán phát hiện vùng bất thường trên ảnh MRI não.
فضائلُ "سُوْرَة آل عِمْرَان" وخَوَاصُّها في ضوء الأحاديث الصَّحيحة: دراسةٌ تحليليةٌ
Authors: الغوري سید عبد الماجد 
Published: June 2024

"سُوْرَةُ آل عِمْرَان" من السُّوَر الجليلة في القرآن الكريم، وهي تدعو إلى الثَّبات في الإسلام بعد كماِله وبيانِه، وتَرُدُّ شُبُهاتِ أهل الكتاب ولا سِيَّما النَّصَارى. كما وَرَد في فضائلِها العديدُ من الأحاديث النبوية، منها: أنَّ في هذه السُّوْرَةِ اسمَ الله الأَعْظَم الذي هو "الْحَيُّ القَيُّوْمُ"، وأنَّ هذه السُّوْرَةَ و"سُوْرَةَ البَقَرَة" تُحَاجَّانِ عن قارئهما يومَ القِيَامة، وغيرهما من الفضائل التي وردتْ في الأحاديث الصَّحيحة. وهذا البحثُ يتناول دراسةَ ما وَرَد في تلك الأحاديث مِن فضائل هذه السُّوْرَةِ، ثم يَذكُر خَوَاصَّها في ضوء تلك الأحاديث. وقد استخدم الباحثُ في هذه الدراسة منهجَين: المنهج الاستقرائيّ والمنهج التحليليّ، أمَّا المنهجُ الاستقرائيُّ فقد اتَّبَعَه لتَتَبُّعِ وجَمْعِ الأحاديث الصَّحيحة الواردة في فضائل هذه السُّوْرَةِ وخَوَاصِّها، وأمَّا المنهجُ التحليليُّ فقد اتَّبَعَه في تحليل نصوص تلك الأحاديث والاستنباطِ منها. وخَتَم البحثَ بذكر عددٍ من النتائج المهمَّة التي استخلصها من هذه الدراسة، ومَفَادُها: أنَّ مَن أرادَ العَمَلَ بهذه السُّوْرَةِ، والاستفادةَ مِن خاصِّيّتها فعليه أن يتدبَّر ويتأمَّل في معانيها، ويَتَّعِظَ ويَعتبِرَ بما جاءَ فيها من التَّعاليم والحِكَم، والأوامِر والزَّوَاجِر.
Analisis Permainan Tradisional Untuk Pengembangan Keterampilan Proses Sains Anak Di Desa Ekowisata Pampang Gunungkidul
Authors: Wahyuni Fajar Arum  , Kartika Fajar Nieamah  
Published: June 2024

This study aims to determine (1) the influence of traditional game media on the science process skills of children tourist in Pampang Gunungkidul Yogyakarta ecotourism village and (2) the influence of traditional game media on the social skills of children tourist in the Pampang Gunungkidul Yogyakarta ecotourism village. Research type used in this study is Research and Development. The data collection methods in this study used test, observation, documentation and also interviews. The test methods used in this study pre-test and post test in the form of multiple choice. The conclusions of this study are 1) learning media in the form of traditional games have an influence on science process skills. This is based on the t test carried out on the pre-test and post test data which shows that the velue of t table is 2.04841 while t arichmetic is -14.748. These result indicate that the value of t table > t arithmetic thus, it can be concluded that there is an influence on social skills. This can be seen from the results of the social skills observation which show that tourist who have high social skills have a frequency of 16 people while tourists children who have low social skills have a frequency of 14 people.
Likelihood of Diabetes Mellitus Associated with Frozen Shoulder
Authors: Zubair Muhammad , Saleem Salman Ahmad , Iqbal Sajida , Iqbal Sajida , Durrani Naveed Ahmad , Hasan Nafees ul , Ali Hasan 
Published: June 2024

Background: Frozen Shoulder (FS), is an extremely debilitating shoulder condition that causes serious functional impairment in activities of routine work. FS causes disability in 2-3 percent of the population. In Pakistan, fewer studies have been conducted in the past describing the association between diabetes with FS. Through this study, we would like to study links, create awareness among physicians, patients and treat the underlying disease to reduce morbidity. Our study objective is to find the prevalence of diabetes in patients with FS from Islamabad and Rawalpindi.
Subjects and Methods: Patients >18 years with shoulder pain or stiffness attending Shifa Medical and Pain Clinic were identified. Institutional review board and Ethical Committee approval and informed consent were obtained from the participants. A preformed questionnaire was used for the survey. The statistical analysis was carried out using the SPSS 23 version to evaluate the relationship between FS and age, sex, presence of diabetes, and control by HbA1c levels.
Results: Data of 700 patients, 206(29.4%) males 494(70.6%) females with MA±SD of 54±9. 287(41%) patients were found Diabetic with FS. 228(79.4%) diabetic patients were poorly controlled having HbA1c levels of more than 7%. The patient had high HbA1c levels showing a strong correlation of uncontrolled Diabetes with FS. 39(9.4%) patients with FS were incidentally diagnosed with diabetes.
Conclusion: Patients with frozen shoulder should be subjected to routine diabetes investigation and control should be monitored by blood glucose and HbA1c levels. Patients with diabetes should also be made aware of the role of glycemic control in the management of FS to prevent morbidity.
ANALISIS PEMAHAMAN MAHASISWA TERHADAP KONSEP DASAR ASET, KEWAJIBAN, EKUITAS, DAN JURNAL DALAM MENINGKATKAN EFEKTIVITAS PRAKTIK KERJA LAPANGAN
Authors: Ummarha Nadhifah Yonas , Rissi Dita Maretha , Sriyunianti Fera , Ermatati Hatta  
Published: June 2024

This research aims to understand students' comprehension of the fundamental concepts of assets, liabilities, equity, and journals in enhancing the effectiveness of Work Practice (Internship). The study employs a qualitative research approach, with the research informants being 30 students from the Accounting Department of Politeknik Negeri Padang, selected based on their GPA grouping. The research was conducted on final-year students of the Accounting Department of Politeknik Negeri Padang for the academic year 2022/2023, namely the Diploma of Accounting and Applied Bachelor of Accounting. The research findings indicate that (1) a number of students with an accounting background have an initial advantage in comprehending basic accounting concepts. (2) several conditions related to students' understanding of the concepts of assets, liabilities, equity, and journals were identified. (3) enhancing students' comprehension and improving the effectiveness of fieldwork practices, collaborative efforts between educational institutions and relevant industry stakeholders are necessary.