bluuebunny/crossref_metadata_2025_split huggingface dataset:
Smoking increases risk of pain chronification through shared corticostriatal circuitry
Authors: Petre Bogdan , Torbey Souraya , Griffith James W. , De Oliveira Gildasio , Herrmann Kristine , Mansour Ali , Baria Alex T. , Baliki Marwan N. , Schnitzer Thomas J. , Apkarian Apkar Vania 
Published: October 2014

AbstractSmoking is associated with increased incidence of chronic pain. However, the evidence is cross‐sectional in nature, and underlying mechanisms remain unclear. In a longitudinal observational study, we examined the relationship between smoking, transition to chronic pain, and brain physiology. In 160 subjects with subacute back pain (SBP: back pain lasting 4–12 weeks, and no prior back pain [BP] for at least 1 year) pain characteristics, smoking status, and brain functional properties were measured repeatedly over 1 year. Sixty‐eight completed the study, subdivided into recovering (SBPr, n = 31) and persisting (SBPp, n = 37), based on >20% decrease in BP over the year. Thirty‐two chronic back pain (CBP: duration > 5 years) and 35 healthy controls were similarly monitored. Smoking prevalence was higher in SBP and CBP but not related to intensity of BP. In SBP, smoking status at baseline was predictive of persistence of BP 1 year from symptom onset (differentiating SBPp and SBPr with 0.62 accuracy). Smoking status combined with affective properties of pain and medication use improved prediction accuracy (0.82). Mediation analysis indicated the prediction of BP persistence by smoking was largely due to synchrony of fMRI activity between two brain areas (nucleus accumbens and medial prefrontal cortex, NAc‐mPFC). In SBP or CBP who ceased smoking strength of NAc‐mPFC decreased from precessation to postcessation of smoking. We conclude that smoking increases risk of transitioning to CBP, an effect mediated by corticostriatal circuitry involved in addictive behavior and motivated learning. Hum Brain Mapp 36:683–694, 2015. © 2014 Wiley Periodicals, Inc.
Reduced CMRO2 and cerebrovascular reserve in patients with severe intracranial arterial stenosis: A combined multiparametric qBOLD oxygenation and BOLD fMRI study
Authors: Bouvier Julien , Detante Olivier , Tahon Florence , Attye Arnaud , Perret Thomas , Chechin David , Barbieux Marianne , Boubagra Kamel , Garambois Katia , Tropres Irène , Grand Sylvie , Barbier Emmanuel L. , Krainik Alexandre 
Published: October 2014

AbstractMultiparametric quantitative blood oxygenation level dependent (mqBOLD) magnetic resonance Imaging (MRI) approach allows mapping tissular oxygen saturation (StO2) and cerebral metabolic rate of oxygen (CMRO2). To identify hemodynamic alteration related to severe intracranial arterial stenosis (SIAS), functional MRI of cerebrovascular reserve (CVR BOLD fMRI) to hypercapnia has been proposed. Diffusion imaging suggests chronic low grade ischemia in patients with impaired CVR. The aim of the present study was to evaluate how oxygen parameters (StO2 and CMRO2), assessed with mqBOLD approach, correlate with CVR in patients (n = 12) with SIAS and without arterial occlusion. The perfusion (dynamic susceptibility contrast), oxygenation, and CVR were compared. The MRI protocol conducted at 3T lasted approximately 1 h. Regions of interest measures on maps were delineated on segmented gray matter (GM) of middle cerebral artery territories. We have shown that decreased CVR is spatially associated with decreased CMRO2 in GM of patients with SIAS. Further, the degree of ipsilateral CVR reduction was well‐correlated with the amplitude of the CMRO2 deficit. The altered CMRO2 suggests the presence of a moderate ischemia explained by both a decrease in perfusion and in CVR. CVR and mqBOLD method may be helpful in the selection of patients with SIAS to advocate for medical therapy or percutaneous transluminal angioplasty‐stenting. Hum Brain Mapp 36:695–706, 2015. © 2014 Wiley Periodicals, Inc.
Analysis of self‐feeding in children with feeding disorders
Authors: Rivas Kristi M. , Piazza Cathleen C. , Roane Henry S. , Volkert Valerie M. , Stewart Victoria , Kadey Heather J. , Groff Rebecca A. 
Published: October 2014

AbstractIn the current investigation, we evaluated a method for increasing self‐feeding with 3 children with a history of food refusal. The children never (2 children) or rarely (1 child) self‐fed bites of food when the choice was between self‐feeding and escape from eating. When the choice was between self‐feeding 1 bite of food or being fed an identical bite of food, self‐feeding was low (2 children) or variable (1 child). Levels of self‐feeding increased for 2 children when the choice was between self‐feeding 1 bite of food or being fed multiple bites of the same food. For the 3rd child, self‐feeding increased when the choice was between self‐feeding 1 bite of food or being fed multiple bites of a less preferred food. The results showed that altering the contingencies associated with being fed increased the probability of self‐feeding, but the specific manipulations that produced self‐feeding were unique to each child.
Bone substitute materials supplemented with prolyl hydroxylase inhibitors decrease osteoclastogenesis in vitro
Authors: Vinzenz Philipp , Schröckmair Stefan , Gruber Reinhard , Agis Hermann 
Published: October 2014

AbstractBackground and objective: Inhibition of prolyl hydroxylases stimulates bone regeneration. Consequently, bone substitute materials were developed that release prolyl hydroxylase inhibitors. However, the impact of prolyl hydroxylase inhibitors released from these carriers on osteoclastogenesis is not clear. We therefore assessed the effect of bone substitute materials that release prolyl hydroxylase inhibitors on osteoclastogenesis. Material and methods: Dimethyloxalylglycine, desferrioxamine, and l‐mimosine were lyophilized onto bovine bone mineral and hydroxyapatite, and supernatants were generated. Osteoclastogenesis was induced in murine bone marrow cultures in the presence of the supernatants from bone substitute materials. The formation of tartrate‐resistant acid phosphatase (TRAP)‐positive multinucleated cells and TRAP activity were determined. To test for possible effects on osteoclast progenitor cells, we measured the effect of the supernatants on proliferation and viability. In addition, experiments were performed where prolyl hydroxylase inhibitors were directly added to the bone marrow cultures. Results: We found that prolyl hydroxylase inhibitors released within the first hours from bone substitute materials reduce the number and activity of TRAP‐positive multinucleated cells. In line with this, addition of prolyl hydroxylase inhibitors directly to the bone marrow cultures dose‐dependently reduced the number of TRAP‐positive multinucleated cells and the overall resorption activity. Moreover, the released prolyl hydroxylase inhibitors decreased proliferation but not viability of osteoclast progenitor cells. Conclusion: Our results show that prolyl hydroxylase inhibitors released from bone substitute materials decrease osteoclastogenesis in murine bone marrow cultures. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1198–1203, 2015.
7 tesla magnetic resonance imaging: A closer look at substantia nigra anatomy in Parkinson's disease
Authors: Lehéricy Stéphane , Bardinet Eric , Poupon Cyril , Vidailhet Marie , François Chantal 
Published: October 2014

AbstractA hallmark of Parkinson's disease (PD) is the progressive neurodegeneration of dopaminergic neurons in the substantia nigra pars compacta (SNc). Dopaminergic denervation is commonly imaged using radiotracer imaging in target structures such as the striatum. Until recently, imaging made only a modest contribution to detecting neurodegenerative changes in the substantia nigra (SN) directly. Histologically, the SN is subdivided into the ventral pars reticulata and the dorsal pars compacta, which is composed of dopaminergic neurons. In humans, dopaminergic neurons, which are known to accumulate neuromelanin, form clusters of cells (nigrosomes) that penetrate deep into the SN pars reticulata (SNr). The SNr contains higher levels of iron than the SNc in normal subjects. Neuromelanin and T2*‐weighted imaging therefore better detect the SNc and the SNr, respectively. The development of ultra‐high field 7 Tesla (7T) magnetic resonance imaging (MRI) provided the increase in spatial resolution and in contrast that was needed to detect changes in SN morphology. 7T MRI allows visualization of nigrosome‐1 as a hyperintense signal area on T2*‐weighted images in the SNc of healthy subjects and its absence in PD patients, probably because of the loss of melanized neurons and the increase of iron deposition. This review is designed to provide a better understanding of the correspondence between the outlines and subdivisions of the SN detected using different MRI contrasts and the histological organization of the SN. The recent findings obtained at 7T will then be presented in relation to histological knowledge. © 2014 International Parkinson and Movement Disorder Society
OAB epidemiological survey of general gynaecology outpatients and its effects on patient quality of life
Authors: An Fang , Yang Xin , Wang Yan J. , Chen Jian Y. , Wang Jian L. 
Published: October 2014

AimsTo survey the prevalence rate of overactive bladder (OAB) among general gynaecology outpatients, it's connection to common benign gynaecological diseases and its effects on patient quality of life (QOL).MethodA questionnaire survey on urination and its effects on QOL was administered to 2500 general gynaecology outpatients aged ≥18 who visited our hospital which is in Peking between October and November 2012. Additionally, their menstrual history and diseases were documented, according to their medical records.ResultsIn total, 2161 effective questionnaires (86.4%) were collected from the respondents, who were aged 18–97 years. The overall OAB prevalence rate was 8.8% (191/2161), and the OAB prevalence rate in women >50 years was significantly higher (X2 = 7.656, P < 0.05). Moreover, the OAB prevalence rate (25.8%) among patients suffering from pelvic organ prolapse was significantly higher than the rate (8.6%) among patients without pelvic organ prolapse (X2 = 11.238, P < 0.05). Multi‐factor logistic regression indicated that age (OR = 1.504, 95% CI = 1.072–2.111) and pelvic organ prolapse (OR = 2.512, 95% CI = 1.109–5.688) were risk factors for OAB among the respondents. Additionally, with the rise of OAB severity, its effects on the QOL of OAB patients, like urinary urgency, nocturia, frequency and urge incontinence increased accordingly.ConclusionsThe OAB prevalence rate among general gynaecology outpatients was 8.8%, and the effects of OAB on QOL increased with the worsening of the disease. Neurourol. Urodynam. 35:29–35, 2016. © 2014 Wiley Periodicals, Inc.
Update on 2‐year outcomes of the TOMS™ transobturator male sling for the treatment of male stress urinary incontinence
Authors: Yiou Rene , Bütow Zentia , Parisot Juliette , Lingombet Odile , Augustin Déborah , de la Taille Alexandre , Salomon Laurent , Audureau Etienne 
Published: October 2014

AimsTo update the 2‐year outcomes of the TOMS™ transobturator male sling for treating post‐prostatectomy urinary incontinence (pRP‐UI) in a group of patients previously evaluated at 1 year.MethodsWe prospectively followed 40 patients with pRP‐UI before and 6, 12, and 24 months after implantation of the TOMS™ transobturator male sling. Urinary symptoms were evaluated using the following questionnaires: USP, ICIQ, UCLA‐PCI (urinary bother domain), PGI‐I, and daily pad use. Success was defined as patients wearing no or only one security pad. We also report on any other surgical procedures for treating persistent incontinence during the follow‐up period.ResultsOf 40 patients included in the 1‐year follow‐up, seven required additional surgical treatment. In the remaining patients (n = 33), significant improvement (P < 0.001) compared to baseline was seen, and a subsequent tendency (non‐significant) toward impairment was noted throughout the three postoperative follow‐ups for the ICIQ (14.4 ± 4.4 [baseline], 7.6 ± 5.7 [6 months], 8.1 ± 5.6 [12 months], 8.9 ± 5.5 [24 months]), USP‐stress urinary (6.7 ± 2.2, 2.8 ± 2.4, 2.8 ± 2.4, 3.2 ± 2.8), ULCA‐PCI‐urinary bother (10.0 ± 12.5, 66.0 ± 33.0, 64.0 ± 31.5, 62.0 ± 30.7) scores, and pad use (2.5 ± 1.2, 0.7 ± 1.1, 0.8 ± 1.2, 0.9 ± 1.2). Significant impairment in postoperative PGI‐I (6.2 ± 0.9, 6.1 ± 0.9, 5.8 ± 1.1, P = 0.028) and USP‐overactive bladder symptoms scores (5.4 ± 3.6 [6 months] vs. 6.6 ± 3.7 [24 months], P = 0.046) were noted. A total of 18 (54.5%), 17 (51.5%), and 15 (45.5%) patients wore no postoperative pad, respectively.ConclusionApproximately half of the patients continue to wear no pad 2 years after TOMS™ transobturator male sling implantation. However, a tendency toward impaired continence, possibly associated with overactive bladder symptoms, was noted. Neurourol. Urodynam. 35:44–47, 2016. © 2014 Wiley Periodicals, Inc.
Prevalence of urinary incontinence and associated factors in nursing home residents
Authors: Jerez‐Roig Javier , Santos Marquiony M. , Souza Dyego L.B. , Amaral Fabienne Louise J.S. , Lima Kenio C. 
Published: October 2014

AimsTo determine the prevalence of urinary incontinence (UI) and associated factors in the institutionalized elderly.MethodsA cross‐sectional study is presented herein, conducted between October and December 2013, in 10 nursing homes in the city of Natal (Northeast Brazil). Individuals over the age of 60, who reside in institutions, were included. Hospitalized individuals and those at end of life were excluded. Data collection included sociodemographic information, UI characterization, as well as variables related to the institution itself and to health conditions (comorbidities, medication, pelvic floor surgery, Barthel Index for functional capacity, and Pfeiffer test for cognitive status). UI was verified through the Minimum Data Set (MDS) version 3.0, which was also used to assess urinary devices and UI toileting programs. The Chi‐square test (or Fisher's exact test), the linear Chi‐square test, and logistic regression were utilized to model associations.ResultsThe final sample consisted of 321 elderly, mostly females, with a mean age of 81.5 years. The prevalence of UI was 58.88% (CI 95%: 53.42–64.13) and the final model revealed a statistically significant association between UI and white race, physical inactivity, stroke, mobility impairment, and cognitive decline. The most frequent UI type was functional UI and toileting programs (prompted voiding) were only applied to approximately 8% of residents.ConclusionsIt is concluded that UI is a health issue that affects more than half of the institutionalized elderly, and is associated with white race, physical inactivity, stroke, and other geriatric syndromes such as immobility and cognitive disability. Neurourol. Urodynam. 35:102–107, 2016. © 2014 Wiley Periodicals, Inc.
The ecology of internal workplace giving at Indiana University: a case study of faculty and staff campus campaign communications and fundraising
Authors: Shaker Genevieve G. , Kienker Brittany L. , Borden Victor M. H. 
Published: October 2014

This collective case study examines university‐specific philanthropic cultures, campus fundraising campaigns, and their impact on faculty and staff giving to the university. Drawing on both qualitative and quantitative data, the study documents fundraising strategies through interviews and materials analysis and assesses their results through quantitative data on characteristics of donors and their philanthropic gifts. Examination of fundraising methods reveals differences between demand and supply‐side communication strategies with faculty and staff members as internal stakeholders and donors. Concentrating on the campuses of Indiana University, a large, highly diverse public institution in the American Midwest, this study includes analysis of the outcomes of the fundraising process across institutions of different sizes, demographics, and philanthropic cultures. The findings underscore the importance of exploring the characteristics that influence employee donation behaviors as context for the creation and enactment of fundraising campaigns and highlight the need for future research in the area of workplace giving.Copyright © 2014 John Wiley & Sons, Ltd.
Ifosfamide and vinorelbine is an effective reinduction regimen in children with refractory/relapsed Hodgkin lymphoma, AHOD00P1: A children's oncology group report
Authors: Trippett Tanya M. , Schwartz Cindy L. , Guillerman R. Paul , Gamis Alan S. , Gardner Sharon , Hogan Shirley , London Wendy B. , Chen Lu , de Alarcon Pedro 
Published: October 2014

BackgroundWe assessed the safety and efficacy of ifosfamide and vinorelbine (IV) as a less toxic and effective reinduction regimen for pediatric patients with relapsed or refractory Hodgkin Lymphoma.ProcedureThis multi‐center Children's Oncology Group phase II pilot study enrolled patients <30 years of age with biopsy‐proven Hodgkin Lymphoma in relapse or refractory disease after front‐line therapy. Treatment consisted of ifosfamide 3,000 mg/m2 intravenous infusion over 24 hr on Days 1–4 and vinorelbine 25 mg/m2/dose intravenous push on Days 1 and 5 of each 21 day cycle with cytokine support. The study endpoints included estimation of key toxicities (cardiac, hepatic, or renal toxicity or toxic death), the rate of successful peripheral stem cell harvesting, and response after two cycles of therapy.ResultsSixty‐six patients received a median of two cycles of IV. Sixty‐four of 66 were heavily pretreated, 4 had refractory disease, 55% were male and 79% had nodular sclerosis HL. The primary toxicities were hematologic. Harvested peripheral stem cells were sufficient for autologous transplantation in 46 of 54 patients for whom stem cell collection was attempted. The overall response rate (72%; 95% CI 59–83%) permitted the majority of patients to undergo subsequent stem cell transplantation.ConclusionsIV is a safe and effective re‐induction regimen for salvage of pediatric patients with relapsed or refractory Hodgkin Lymphoma with an excellent response rate and success of post chemotherapy stem cell harvest. It avoids the use of etoposide, an agent associated with secondary malignancy after stem cell transplantation. Pediatr Blood Cancer 2015;62:60–64. © 2014 Wiley Periodicals, Inc.
Targeting histone deacetylases (HDACs) and Wee1 for treating high‐risk neuroblastoma
Authors: Hanmod Santosh S. , Wang Guan , Edwards Holly , Buck Steven A. , Ge Yubin , Taub Jeffrey W. , Wang Zhihong 
Published: October 2014

AbstractBackgroundDespite advances in treatment regimens, patients with high‐risk neuroblastoma have long‐term survival rates of < 40%. Wee1 inhibition in combination with CHK1 inhibition has shown promising results in neuroblastoma cells. In addition, it has been demonstrated that panobinostat can downregulate CHK1. Therefore, combination of panobinostat and MK‐1775 may result in synergistic cytotoxicity against neuroblastoma cell lines.ProcedureIn vitro cytotoxicities of panobinostat and MK‐1775 at clinically achievable concentrations, either alone or in combination, were evaluated in SK‐N‐AS, SK‐N‐DZ, and SK‐N‐BE(2) high‐risk neuroblastoma cell lines using MTT assays. The mechanism of antitumor interaction was investigated using propidium iodide (PI) staining and flow cytometry analysis to determine apoptosis, as well as Western blotting to assess expression of phosphorylated CDK1/2, CHK1, and H2AX.ResultsTreatment of neuroblastoma cell lines with 500 nM MK‐1775 caused growth arrest and apoptosis in SK‐N‐DZ and SK‐N‐AS, while it had minimal effect on the SK‐N‐BE(2) cell line. The combination of panobinostat and MK‐1775 resulted in synergistic antitumor interactions in all three of the cell lines tested. MK‐1775 treatment in SK‐N‐BE(2) cells induced increased levels of p‐CHK1S345, which could be decreased by the addition of panobinostat. This was accompanied by increased DNA damage and apoptosis.ConclusionsThe combination of panobinostat and MK‐1775 has synergistic antitumor activity against neuroblastoma cell lines and holds promise as a potential treatment strategy for the management of high‐risk neuroblastoma patients. Pediatr Blood Cancer 2015;62:52–59. © 2014 Wiley Periodicals, Inc.
Phase I trial of Seneca Valley Virus (NTX‐010) in children with relapsed/refractory solid tumors: A report of the Children's Oncology Group
Authors: Burke Michael J. , Ahern Charlotte , Weigel Brenda J. , Poirier John T. , Rudin Charles M. , Chen Yingbei , Cripe Timothy P. , Bernhardt M. Brooke , Blaney Susan M. 
Published: October 2014

BackgroundTo determine the MTD of Seneca Valley Virus (NTX‐010) in children with relapsed/refractory solid tumors. Patients (≥3–≤21 years) with neuroblastoma, rhabdomyosarcoma, or rare tumors with neuroendocrine features were eligible.ProcedurePart A (single dose of NTX‐010) enrolled 13 patients at three dose levels (1 × 109 viral particles (vp)/kg [n = 6], 1 × 1010 vp/kg [n = 3], 1 × 1011 vp/kg [n = 4]). Diagnoses included neuroblastoma (n = 9), rhabdomyosarcoma (n = 2), carcinoid tumor (n = 1), and adrenocorticocarcinoma (n = 1). Part B added cyclophosphamide (CTX) (oral CTX (25 mg/m2/day) days 1–14 and IV CTX (750 mg/m2) days 8 and 29) to two doses of NTX‐010 (1 × 1011 vp/kg, days 8 and 29). Nine patients enrolled to Part B. Diagnoses included neuroblastoma (n = 3), rhabdomyosarcoma (n = 1), Wilms tumor (n = 3), and adrenocorticocarcinoma (n = 2).ResultsTwelve patients on Part A were evaluable for toxicity. There was a single DLT (grade 3 pain) at dose level 1. Additional grade ≥3 related adverse events (AEs) included leukopenia (n = 1), neutropenia (n = 3), lymphopenia (n = 3), and tumor pain (n = 1). No DLTs occurred on part B. Other grade ≥3 related AEs on Part B included: Leukopenia (n = 3), nausea (n = 1), emesis (n = 1), anemia (n = 1), neutropenia (n = 4), platelets (n = 1), alanine aminotransferase (n = 1), and lymphopenia (n = 2). All patients cleared NTX‐010 from blood and stool by 3 weeks with 17/18 patients developing neutralizing antibodies.ConclusionNTX‐010 is feasible and tolerable at the dose levels tested in pediatric patients with relapsed/refractory solid tumors either alone or in combination with cyclophosphamide. However, despite the addition of cyclophosphamide, neutralizing antibodies appeared to limit applicability. Pediatr Blood Cancer 2015;62:743–750. © 2014 Wiley Periodicals, Inc.
Effects of starch alkenylsuccinylation on the grafting efficiency, paste viscosity, and film properties of alkenylsuccinylated starch‐g‐poly(acrylic acid)
Authors: Zhu Zhifeng , Zhang Longqiu , Li Manli , Zhou Yongsheng 
Published: October 2014

AbstractCommercial cornstarch was alkenylsuccinylated with alkenylsuccinic anhydride to different degrees of substitution (DS) and then the products were graft‐copolymerized with acrylic acid for investigating the effects of starch alkenylsuccinylation on the graft copolymerization with vinyl monomer, as well as on paste viscosity and film properties of alkenylsuccinylated starch‐g‐poly(acrylic acid) (ASS‐g‐PAA). The number of carbon atom of alkenyl in alkenylsuccinates considered was 8 and 12, corresponding to octenylsuccinylation and dodecenylsuccinylation of starch, respectively. The graft copolymerization was accessed by grafting efficiency, grafting ratio, and conversion of monomer to polymer, and the film properties of ASS‐g‐PAA considered included tensile strength, breaking elongation, and work‐to‐break. Experimental results demonstrated that the alkenylsuccinylation showed marked effects on the copolymerization, paste viscosity, and film properties. It resulted in increased grafting efficiency, stable paste viscosity, and strong starch film. Carbon‐chain length of the alkenyl and DS value of the alkenylsuccinates also exhibited evident effects on the copolymerization and film properties. Octenylsuccinylation of starch before the copolymerization was superior to dodecenylsuccinylation in improving the efficiency and film properties. Low levels of octenylsuccinylation could be utilized to increase the efficiency of the copolymerization and improve the properties of starch film.