bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of aromatic plants hydrosols on the growth of Trichoderma harzianum
Authors: Ruíz-González Miguel A. , Colmena-Chino Diego R. , Jerónimo-Ponce Fernando , Solano-Vidal Roney , Serrato Cruz Miguel Ángel 
Published: August 2024

Objective: To evaluate the compatibility of hydrosols from aromatic plants in the growth of T. harzianum.
Design/Methodology/Approach: All hydrosols of Foeniculum vulgare, Plectranthus coleoides, Tagetes arenicola, T. coronopifolia, T. erecta, and T. lucida were evaluated in vitro on the mycelium Trichoderma Harzianum. Their growth rates and inhibition percentages were recorded. T. harzianum was inoculated in 50 g of sterilized corn cob enriched with F. vulgare hydrosol (3, 5 and 7%), this mixture was incubated at 28 ±2 °C; spore counting, and viability tests were performed on PDA medium. The Tukey test (p ≤ 0.05) was used for mean comparisons.
Results: All hydrosols inhibited in vitro the mycelial growth of T. harzianum at 100%, but at 5% concentration, some hydrosols promoted the growth of the fungus more than the control. The concentration of F. vulgare hydrosol influenced the production and viability of T. harzianum spores in the cob substrate.
Study Limitations/Implications: This study provides Information on the use of hydrosol, which are typically considered waste products.
Findings/Conclusions: At low concentration, F. vulgare hydrosol can be used to enrich corn cob and promote the growth of T. harzianum.
Does conventional early life academic excellence predict later life scientific discovery? An assessment of the lives of great medical innovators
Authors: Jenkins David J. A. , H. Jayalath Viranda , Choo Vivian L. , Viguiliouk Effie , Kendall Cyril W. C. , Srichaikul Korbua , Mirrahimi Arash , Bernstein Charles , Chang Thomas M S , Gold Phil , Haynes B. , D. Hollenberg Morley , M. Lozano Andres , I. Posner Barry , Ronald Allan , Vranic Mladen , Wang Yu Tian , Chiavaroli Laura , Souza Russell J. de , Nishi Stephanie , Pichika Sathish Chandra , Gillett Chantal , Tsirakis Tom , Sievenpiper John L 
Published: August 2024

<p>Background</p>
<p>Perhaps, as never before, we need innovators. With our growing population numbers, and with increasing pressures on our education systems, are we in danger of becoming more rigid and formulaic and increasingly inhibiting innovation? When young can we predict who will become the great innovators? For example, in medicine, who will change clinical practice?</p>
<p>Aims</p>
<p>We therefore determined to assess whether the current academic excellence approach to medical school entrance would have captured previous great innovators in medicine, assuming that they should all have well fulfilled current entrance requirements.</p>
<p>Methods</p>
<p>The authors assembled a list of 100 great medical innovators which was then approved, rejected or added to by a jury of 12 MD fellows of the Royal Society of Canada. Two reviewers, who had taken both the past and present Medical College Admission Test as part of North American medical school entrance requirements, independently assessed each innovator’s early life educational history in order to predict the innovator’s likely success at medical school entry, assuming excellence in all entrance requirements.</p>
<p>Results</p>
<p>Thirty-one percent of the great medical innovators possessed no medical degree and 24% would likely be denied entry to medical school by today’s standards (e.g. had a history of poor performance, failure, dropout or expulsion) with only 24% being guaranteed entry. Even if excellence in only one topic was required, the figure would only rise to 41% certain of medical school entry.</p>
<p>Conclusion</p>
<p>These data show that today’s medical school entry standards would have barred many great innovators and raise questions about whether we are losing medical innovators as a consequence. Our findings have important implications for promoting flexibility and innovation for medical education, and for promoting an environment for innovation in general. </p>
Effect of almond consumption on the serum fatty acid profile: a dose-response study
Authors: Nishi Stephanie , Kendall Cyril W. C. , Gascoyne Ana-Maria , P. Bazinet Richard , Bashyam Balachandran , Lapsley Karen G. , Augustin Livia S. A. , Sievenpiper John L , Jenkins David J A 
Published: August 2024

<p>Consumption of almonds has been shown to be associated with a decreased risk of CHD, which may be related to their fatty acid (FA) composition. However, the effect of almond consumption on the serum FA composition is not known. Therefore, in the present study, we investigated whether almond consumption would alter the serum FA profile and risk of CHD, as calculated using Framingham's 10-year risk score, in a dose-dependent manner in hyperlipidaemic individuals when compared with a higher-carbohydrate control group using dietary interventions incorporating almonds. A total of twenty-seven hyperlipidaemic individuals consumed three isoenergetic (mean 1770 kJ/d) supplements during three 1-month dietary phases: (1) full-dose almonds (50–100 g/d); (2) half-dose almonds with half-dose muffins; (3) full-dose muffins. Fasting blood samples were obtained at weeks 0 and 4 for the determination of FA concentrations. Almond intake (g/d) was found to be inversely associated with the estimated Framingham 10-year CHD risk score (<em>P</em>= 0·026). In both the half-dose and full-dose almond groups, the proportions of oleic acid (OA) and MUFA in the TAG fraction (half-almond: OA <em>P</em>= 0·003; MUFA <em>P</em>= 0·004; full-almond: OA <em>P</em>< 0·001; MUFA <em>P</em>< 0·001) and in the NEFA fraction (half-almond: OA <em>P</em>= 0·01; MUFA <em>P</em>= 0·04; full-almond: OA <em>P</em>= 0·12; MUFA <em>P</em>= 0·06) increased. The estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (<em>P</em>= 0·011) and MUFA (<em>P</em>= 0·016) content in the TAG fraction. The proportions of MUFA in the TAG and NEFA fractions were positively associated with changes in HDL-cholesterol concentrations. Similarly, the estimated Framingham 10-year CHD risk score was inversely associated with the percentage change of OA (<em>P</em>= 0·069) and MUFA content in the NEFA fraction (<em>P</em>= 0·009). In conclusion, the results of the present study indicate that almond consumption increases OA and MUFA content in serum TAG and NEFA fractions, which are inversely associated with CHD lipid risk factors and overall estimated 10-year CHD risk.</p>
Confluencias del “Buen Diseño” en Centros Disímiles de Diseño: Un análisis comparativo del KDPC de Corea y el CIDI de Argentina
Authors: Kim Eliana 
Published: August 2024

En el presente artículo se desarrolla una comparación analítica entre los primeros dos centros de diseño en Latinoamérica y Asia, durante las décadas de los 60 y 70: el [Centro de Diseño y Packaging de Corea] (KDPC), ex Hanguk Gongye Design Center [Centro de Artesanía y Diseño] de 1966-1969, KDPC 1970-1991) y el Centro de Investigación de Diseño Industrial- CIDI (1962-1988) de Argentina. El artículo propone dar a conocer la relación que guardan dichos eventos particulares locales en un contexto global dinámico en el que las potencias internacionales obraban en pro de expandir la universalización de la actividad profesional del Diseño Industrial.Con el motivo de comprender en profundidad las relaciones que yacen en la conformación y el desarrollo de las dos instituciones, se utilizó el análisis histórico-comparativo como metodología de investigación.El artículo concluye con que las dos instituciones han sido independientes, en tiempo y espacio, sin intercambios ni reuniones coincidentes en el escenario global; al analizarlas, sí han compartido una serie de similitudes significativas.En primer lugar, cuando imperaron las políticas desarrollistas, ambos países tuvieron la necesidad de crear centros de diseño industrial apoyados por el Estado. Segundo, estos centros fueron los primeros fundados en Asia y Latinoamérica respectivamente, lo cual denota el significado que tuvo el diseño en ambos países. Finalmente, comparten un par de características en su orientación; por un lado, fueron guiados de manera externa por profesionales vinculados al International Council of Societies of Industrial Design -ICSID; por el otro, internamente estuvieron ligados a los comités facultativos de las dos universidades públicas más importantes de su país: el departamento de Artes Aplicadas de la Universidad Nacional de Seúl (SNU), en el caso del KDPC; y la Facultad de Arquitectura (FAU) de la Universidad de Buenos Aires (UBA), en el caso del CIDI.
Karakter Morfologis dan Ekologis Coffea arabica L. di Perkebunan Rakyat dan Perhutani Pandansari Malang
Authors: Shalehah Nikmatus , Hakim Luchman , Zayadi Hasan 
Published: August 2024

The conditions in which plants grow affect plant growth and development. If the conditions in which the plant grows are not suitable, its growth will be disrupted and the yield of plant production is not optimal. This research was carried out in two locations, namely in Perhutani land with an altitude of 1110 meters above sea level and community plantations with an altitude of 914 meters above sea level. The type of research used is descriptive qualitative with exploratory sampling. The results showed that ecological factors affect plant morphology. Different light intensities cause the leaves on smallholder plantations to be smaller in size to reduce water evaporation and the distance between the segments of Coffea arabica L. on perhutani land has a longer internode distance due to etiolation. The shade trees found in smallholder plantations are Maesopsis eminii, Engl., Leucaena leucocephala subsp. Glabrata, Pterocarpus indicus, Hibiscus tiliaceus, Toona sureni, Melia azedarach, Leucaena leucocephala. The shade trees on Perhutani land are Pinus merkusii and Ficus benjamina L.
Keywords: morphology, ecology, Coffea arabica L, shade trees.
ABSTRAK
Kondisi tempat tumbuh tanaman mempengaruhi pertumbuhan dan perkembangan tanaman. Apabila kondisi tempat tumbuh tanaman tidak sesuai maka pertumbuhannya akan terganggu dan hasil produksi tanaman tidak maksimal. Penelitian ini dilaksanakan di dua lokasi yaitu di lahan perhutani dengan ketinggian 1110 m dpl dan perkebunan rakyat dengan ketinggian tempat 914 m dpl. Jenis penelitian yang digunakan adalah kualitatif deskriptif dengan pengambilan sampel secara eksplorasi. Hasil penelitian menunjukkan bahwa faktor ekologi mempengaruhi morfologi tanaman. Intensitas cahaya yang berbeda menyebabkan daun di lahan perkebunan rakyat berukuran lebih kecil untuk mengurangi penguapan air dan jarak antar ruas pada Coffea arabica L. di lahan perhutani memiliki ukuran antar ruas lebih panjang karena etiolasi. Pohon penaung yang terdapat di lahan perkebunan rakyat adalah Maesopsis eminii, Engl., Leucaena leucocephala subsp. Glabrata, Pterocarpus indicus, Hibiscus tiliaceus, Toona sureni, Melia azedarach, Leucaena leucocephala. Pohon penaung di lahan perhutani adalah Pinus merkusii dan Ficus benjamina L.
Kata kunci: morfologi, ekologi, Coffea arabica L, pohon penaung.
Pemanfaatan Limbah-Padat Makanan pada Komponen Serat untuk Bahan Baku Tepung Delignifikasi dengan Perlakuan Hidrogen Peroksida
Authors: Aziz Achmad Qomarul , Syauqi Ahmad , Ramadhan Majida 
Published: August 2024

Waste is currently an environmental problem, and there is a high volume of organic waste, primarily from household and restaurant food waste. Delignification is a process of destroying lignin molecules from the lignocellulose structure with the use of an agent. This study aimed to determine the effect of Hydrogen peroxide ((H2O2) on the water content of delignified flour raw materials and to determine the difference in water content values ​​between the control and treatment of solid food waste fibres. This study used a completely randomized design (CRD) with two factors. The first factor is the concentration level of H2O2 solution with 0%, 0.25%, 0.5%, 0.75%, and 1%; the second factor is the soaking time with 0, 2, 4, and 6 hours of soaking. Data analysis used Two-way ANOVA without replication and the Duncan Multiple Range Test (DMRT). The highest average water content was found at a soaking time of six hours, which was 39.29 g, while the highest average water content was at a concentration factor of 0.25%, 22.8625 g. The Soaking time factor (P=3.54x10-2) and concentration (P=0.131). Based on the analysis, the concentration of H2O2 did not affect the water content of the raw material of flour from the delignification of solid food waste fibre, and the soaking time at the level of six hours of soaking, there was a significant difference (P<0.05) in soaking time according to the Duncan test.
Keywords: Delignification, Hydrogen Peroxide (H2O2), Food Solid Waste
ABSTRAK
Sampah saat ini menjadi permasalahan lingkungan dan tingginya volume sampah organik, terlebih dari sisa makanan rumah tangga dan restoran. Delignifikasi merupakan suatu proses perusakan molekul lignin dari struktur lignoselulosa dengan penggunaan suatu agen. Tujuan penelitian ini untuk mengetahui pengaruh pemberian Hidrogen peroksida (H2O2) terhadap kadar air bahan baku tepung delignifikasi dan mengetahui perbedaan nilai kadar air antara kontrol dan perlakuan pada serat limbah padat makanan. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan dua faktor. Faktor pertama adalah level konsentrasi larutan H2O2 dengan 0%, 0,25%, 0,5%, 0,75%, dan 1%, faktor kedua adalah lama perendaman dengan 0, 2, 4, dan 6 jam perendaman. Analisis data menggunakan Two-way ANOVA without replication dan uji Duncan Multiple Range Test (DMRT). Rata-rata kadar air tertinggi terdapat pada lama perendaman enam jam yaitu 39,29 g, sedangkan rata-rata kadar air tertingi pada faktor konsentrasi 0,25% yaitu 22,8625 g. Faktor lama perendaman (P=3,54x10-2) dan konsentrasi (P=0,131). Berdasarkan analisis konsentrasi H2O2 tidak berpengaruh terhadap kadar air bahan baku tepung dari delignifikasi serat limbah padat makanan, dan lama perendaman pada tingkat enam jam perendaman terdapat perbedaan nyata (P<0,05) waktu perendaman menurut uji Duncan.
Kata kunci: Delignifikasi, Hidrogen Peroxide (H2O2), Limbah Padat Makanan.
¿Es importante trabajar las emociones en Educación Infantil? Revisión Bibliométrica
Authors: Hernández Beltrán Víctor , Pereira Duarte Dámaris , Espada Mário C. , Castelli Correia de Campos Luis Felipe , García Barrera Alba , Gamonales José M. 
Published: August 2024

El empleo de las emociones durante la etapa de Educación Infantil juega un papel fundamental en la construcción de la personalidad y en las interacciones sociales del alumnado. Por ello, el presente trabajo tiene como objetivo analizar el estado del arte relacionado con el estudio de las emociones en Educación Infantil mediante el desarrollo de una revisión bibliométrica, puesto que las evidencias científicas respaldan la importancia del aprendizaje de las emociones. Para ello, se empleó la base de datos Web of Science, identificándose un total de 114 manuscritos relacionados con la temática objeto de estudio. Además, los resultados obtenidos muestran que es un campo incipiente para los investigadores en el ámbito de la Educación Infantil. La mayoría de los documentos se encuentran clasificados en la categoría de Education and Educational Research. Los documentos que presentan un mayor número de citas son de Blair et al. (2004), con 155, y el artículo de Yoshikawa et al. (2015), con 135, encontrándose la mayoría de los manuscritos redactados en inglés. Las evidencias científicas halladas como resultado del presente estudio respaldan la importancia del aprendizaje de las emociones en Educación Infantil, y se recomienda a los investigadores realizar estudios colaborativos y aumentar el número de estudios relacionados con el empleo de las emociones en el aula de Educación Infantil.
A criteria-based progressive rehabilitation program for rectus femoris strain in a recreational soccer player: a case report
Authors: González-de-la-Flor Ángel , García-Pérez-de-Sevilla Guillermo 
Published: August 2024

Introduction: The purpose of this study was to describe the criteria-based progressive rehabilitation program implemented on a recreational soccer player diagnosed with a grade 1 rectus femoris strain.Methods: A 33-year-old male injured the rectus femoris muscle. At the first physical examination, the patient showed significant physical impairment due to important limitations to the active range of motion of the knee flexion and the hip flexor strength. The rehabilitation program consisted of specific training of the rectus femoris, lumbopelvic stabilization, mobility exercises, and running technique exercises, for 6 weeks, which was divided into three phases. Each week, the patient performed four rehabilitation sessions, combined with cross-training (swimming), to maintain his cardiorespiratory capacity.Results: The patient improved functionally and returned to play soccer 6 weeks after the injury without pain. Moreover, the patient passed the criteria of each phase at week 2 for phase 1, at week 4 for phase 2 and at week 6 for phase 3.Conclusion: This case study demonstrates that criteria of progression may control the return to sport timetable for recreational soccer players according to the functional and clinical limitations throughout the entire treatment.
Syndecan-1 as a predictor of vulnerable atherosclerotic plaques
Authors: Qiu Yan , Ouyang Zhi , Zhong Jian , Jin Linlu , Qin Yixue , Zeng Ye 
Published: August 2024

AimsCardiovascular disease remains a major global health concern, with atherosclerosis (AS) being a significant contributor. Vulnerable plaques play a critical role in acute cardiovascular events. Syndecan-1 (SDC-1), a vital membrane proteoglycan in the vascular endothelial glycocalyx, is believed to be associated with plaque progression. However, its precise relationship with severity and vulnerability of atherosclerotic plaque remains unclear. This study aimed to investigate SDC-1 expression and its potential correlation with plaque vulnerability in ApoE−/− atherosclerosis mouse model.Methods and resultsEight-week-old mice were induced into the AS model using a high-fat diet (HFD) and/or partial ligation of the left common carotid artery (PLCA), with a chow diet (CD) control group. After 16 weeks, plaques in the aortic root showed the following order: HFD + PLCA group &gt; HFD group &gt; CD + PLCA group &gt; CD group. Immunohistochemistry revealed heightened accumulation of lipid/foam cells and CD68-labeled macrophages in the plaques, elevated vascular endothelial growth factor (VEGF), and matrix Metalloproteinase-9 (MMP-9) in the HFD + PLCA group’s plaques, along with reduced collagen and α-SMA-labeled smooth muscle cells, resulting in the highest vulnerability index value. Immunohistofluorescence analysis of frozen plaque sections showed significantly higher SDC-1 expression in the AS mice group compared to the CD group, both positively correlated with plaque vulnerability. Serum analysis demonstrated elevated levels of SDC1, sphingosine 1-phosphate (S1P), and VEGF-A in the AS mice, all positively correlated with plaque vulnerability. Multivariate analysis identified SDC1 as an independent predictor of plaque vulnerability.ConclusionThis study enhances our understanding of plaque vulnerability mechanisms and presents SDC1 as a potential biomarker for atherosclerosis. These findings underscore the importance of addressing modifiable risk factors, such as diet and hemodynamics and suggest the utility of serum SDC1 as a valuable clinical marker. Ultimately, these insights may lead to more effective strategies in combating cardiovascular diseases and improving patient outcomes.
Revealing the role of magnetic materials in light-driven advanced oxidation processes: enhanced degradation of contaminants and facilitated magnetic recovery
Authors: González-Fernández Cristina , Bringas Eugenio , Rivero María J. , Ortiz Inmaculada 
Published: August 2024

Semiconductor photocatalysis, heterogeneous photo-Fenton and heterogeneous photocatalytic persulfate activation are light-driven advanced oxidation processes (AOPs) that have attracted much attention as promising technologies in wastewater treatment. Nevertheless, their large-scale application still faces several challenges, including the need to separate the catalyst from the treated water. In this regard, composite catalysts made up of semiconductor and magnetic materials have been understood as a potential alternative since the resulting magnetic photocatalysts can be easily separated from the medium by applying an external magnetic field. Interestingly, apart from facilitating the photocatalyst retrieval, the magnetic components could also be involved in the photocatalytic process. However, while the magnetic separation ability has been widely highlighted, other functions of the magnetic constituents remain obscure. This work, which covers the last 6 years of research, provides a comprehensive review on the magnetically assisted photocatalytic degradation of organic pollutants from water. Specifically, the magnetic photocatalysts that are commonly employed for that purpose are presented and the different roles of their magnetic constituents (roughly grouped as retrieval assistance, active catalyst, conduction medium or activator) are discussed. Furthermore, the importance of designing magnetic separators for attaining the photocatalyst retrieval is also emphasized. Collectively, this study could supply an avenue for developing magnetic photocatalysts that take advantage of both roles of magnetic materials, which can contribute to accomplish a more efficient pollutant degradation.
Mechanism investigation of highly selective inhibitors toward phosphodiesterase 5 and 6 via the in vitro calculation and simulation
Authors: Qu Lihang , Sun Kaijian , Jiang Zhouyu , Wang Ting , Chen Linlin , Shen Chunjian , Gu Ruidong 
Published: August 2024

Introduction: In clinical practice, phosphodiesterase 5 (PDE5) inhibitors are commonly used to treat erectile dysfunction and pulmonary arterial hypertension. However, due to the high structural similarity between PDE5 and Phosphodiesterase 6 (PDE6), there is a risk that existing drugs will cause off-target effects on PDE6 resulting in visual disorders such as low visual acuity and color blindness. Previous research on the selectivity of PDE5 inhibitors focused on marketed drugs such as sildenafil and tadalafil.Methods: In this study, a highly selective PDE5 inhibitor, ligand3, was used as the subject, and molecular docking, molecular dynamics simulations, MM-GBSA, alanine scanning, and independent gradient model analysis were employed to investigate the biological mechanism underlying the selectivity of PDE5 inhibitors.Results and Discussion: The present work revealed that the binding mode of ligand3 to the PDE5A and PDE6C targets was distinctly different. Ligand3 exhibited stronger coulombic forces when binding to PDE5A, while showing stronger van der waals forces when binding to PDE6C. Ligand3 binds more deeply at the active site of PDE5A than at PDE6C, allowing its side chains to effectively bind to the critical TYR612, whereas in the case of the shallow binding to PDE6C, ligand3 lacks a similar effect. Mechanism investigations of highly selective inhibitors through computational simulation might provide an insight into potent treatment of drugs.