bluuebunny/crossref_metadata_2025_split huggingface dataset:
Are shocks to entrepreneurship persistence? Case of a Resource-based economy
Authors: Cheratian Iman , Goltabar Saleh 
Published: July 2024

PurposeThis paper aims to investigate the stationary properties of entrepreneurship capital in the Iranian business sector. The investigation is conducted based on firm size (micro, small and medium, and large), sector (ISIC classification), and location (23 provinces) over the period 1981–2021.Design/methodology/approachTo achieve the purpose of the paper, we apply the Lagrange Multiplier (LM) unit root test with structural breaks.FindingsThe results of our study confirm the stationarity of entrepreneurship for the majority of our categorizations. Therefore, entrepreneurs' willingness to start a business is temporarily affected by sharp shocks, suggesting that the entrepreneurship trends in these categories will eventually revert to their long-run equilibrium. However, the time series of entrepreneurship in provinces such as Zanjan and Lorestan, as well as in the electrical machines and devices (code 31) sector, remain permanent. These findings can assist policymakers in each sector and location in designing effective policies to promote entrepreneurial activities.Research limitations/implicationsIn this study, the time period utilized was restricted, and there were no data accessible for an extended duration. Another limitation of this research is the absence of access to firm-level data on a shorter time scale, such as weekly or monthly.Originality/valueThe economic literature reveals that empirical studies on the persistence of entrepreneurship have received relatively less attention in the context of emerging and resource-based economies, compared to the increasing focus on them in developed countries. Therefore, to address this gap, this paper aims to extend the current empirical literature by presenting new evidence for the case of Iran, which has an emerging and resource-based economy.
Impediments of social responsibility investment adoption system: a post-pandemic qualitative analysis
Authors: Shehzad Ayesha , Khan Kanwal Iqbal 
Published: July 2024

Purpose
Ecological degradation is causing various medical hazards worldwide. Modern globalization is enhancing several polluting factors that cause ecosystem deterioration. This situation leads to the increasing significance of implementing green environmental practices. Previous studies emphasize various green concepts, mainly in finance, encouraging investors to make ethical and responsible decisions to promote clean ecological practices. But still, emerging concepts like socially responsible investment (SRI) require more understanding and acknowledgment, particularly in developing economies.

Design/methodology/approach
This study has focused on exploring the impediments to SRI-adopting practices. It is conducted in two phases. Initially, a systematic literature review was conducted to identify the hurdles in promoting SRI. Later, open-ended interviews from the active investors of Pakistan Stock Exchange Limited were executed to explore the barriers to implementing the SRI system. The responses were transcribed and tested through NVivo software.

Findings
The information extracted from the recorded statements was further classified into three themes: initial, subordinate and cluster, which provides an understanding of the identified factors. The findings suggest that the significant complications hindering SRI are a lack of regulatory framework, inadequate conceptual knowledge and limited resources.

Practical implications
The findings state that the identified impediments can help in developing a framework for successfully implementing SRI practices in emerging economies. It can strengthen the stakeholders' knowledge and suggest a guideline for investment decisions, providing them with socially, ethically and financially positive returns. Therefore, this study will inspire active and potential investors to adopt SRI practices, making the economic uplift certain.

Originality/value
This study will add value to the existing body of knowledge related to SRI and highlight the importance of SRI by suggesting it as a source to ensure sustainable green efficiency, particularly in the postpandemic era. It emphasizes the urgent need for a policy framework for effective investment decisions in emerging economies.
Balancing people, planet and profit: export strategies for sustainable value creation
Authors: Lages Luis Filipe , Silva Graça Miranda , Canhoto Ana Isabel , Martinez Luis F. , Jahanmir Sara 
Published: July 2024

Purpose
Businesses are increasingly called upon to support the improvement of society and the environment, and one way to do so is by expanding into international markets, particularly through exports. Despite the importance and recognised challenges of a global approach to sustainable value creation, sustainability research tends to focus on domestic contexts. This paper aims to identify the boundary conditions linking sustainable value creation practices with firm performance in the international context.

Design/methodology/approach
The authors merge the sustainable value creation and the international marketing literature to develop two propositions that capture the emerging nature of the field and the lack of concluding evidence regarding the link between international sustainable value creation practices and firm performance. The authors test these propositions empirically by analysing 519 responses to a survey of exporting firms in Portugal, using fuzzy-set qualitative comparative analysis.

Findings
The authors identify seven configurations that support sustainable value creation in an international context. These consist of varying levels of standardised and tailored offers, management experience and competitive intensity.

Practical implications
The identification of seven different configurations helps managers decide whether and how to innovate when pursuing sustainable value creation opportunities in international markets.

Social implications
The authors propose that an effective way for governments to achieve national and transnational social and environmental agendas is to help businesses that pursue sustainable value creation to succeed in international markets. Given that four of the seven pathways to improve export performance that the authors identified require international management experience, the authors posit that an effective way to support the internationalisation of those businesses is through targeted training programmes and knowledge-sharing initiatives.

Originality/value
The authors respond to calls for research to integrate the sustainable value creation and the international marketing literatures, to identify how and when firms can create sustainable value creation in an international context and thus support the resolution of global, social and environmental problems. The finding that there are multiple configurations that support this goal explains why empirical evidence collected thus far is inconclusive and helps identify the boundary conditions of existing theory.
Development of digital transformation model in hospital
Authors: Baihaqy Ahmad , Subriadi Apol Pribadi 
Published: July 2024

PurposeThis paper aims to develop a digital transformation model in hospitals. This study proposes a digital transformation model in hospitals by formulating dimensions and sub-dimensions. The proposed hospital digital transformation model outlines why and how each of dimensions and sub-dimensions are important in the hospital digital transformation model.Design/methodology/approachThis study chose the type of qualitative research using a phenomenology approach. This study used observation techniques and in-depth interviews with 11 informants and conducted group discussion forums with information technology governance experts, a hospital information technology department manager who has an information technology background, and doctor representatives. The data were documented and analyzed using triangulation techniques.FindingsThis research provides empirical insights into the dimensions and sub-dimensions of hospital digital transformation models. The findings of the digital transformation dimension in hospitals are 7 dimensions and 37 sub-dimensions, namely, the governance and management dimension which has 8 sub-dimensions; the person has 9 sub-dimensions; strategy dimension which has 5 sub-dimensions; information technology capability has 3 sub-dimensions; the data interoperability dimension has 3 sub-dimensions; the data analytics dimension has 5 sub-dimensions; patient dimensions have 4 sub-dimensions; the findings of the sub-dimensions involved in the digital transformation dimension of the hospital can provide input on the accuracy of the indicators measuring the hospital’s digital transformation.Research limitations/implicationsThis research is limited to the qualitative type of phenomenology approach so that future research can test empirically with quantitative methods with techniques through surveys of dimensional and sub-dimensional relationships to hospital digital transformation. The researchers also recommend further assessing the findings of this paper which can develop as a model for measuring the maturity of hospital digital transformation.Practical implicationsThis paper covers the implications of developing a hospital digital transformation model that can be used to organize and manage hospital digital transformation.Originality/valueThis paper can be used as a guideline for hospital stakeholders when carrying out digital transformation. This paper can be used as a reference for further research to find, study and develop dimensions and sub-dimensions of digital transformation models.
Plasticity in mosquito size and thermal tolerance across a latitudinal climate gradient
Authors: Lyberger Kelsey , Farner Johannah E. , Couper Lisa , Mordecai Erin A. 
Published: July 2024

Abstract

Variation in heat tolerance among populations can determine whether a species is able to cope with ongoing climate change. Such variation may be especially important for ectotherms whose body temperatures, and consequently, physiological processes, are regulated by external conditions.

Additionally, differences in body size are often associated with latitudinal clines, thought to be driven by climate gradients. While studies have begun to explore variation in body size and heat tolerance within species, our understanding of these patterns across large spatial scales, particularly regarding the roles of plasticity and genetic differences, remains incomplete.

Here, we examine body size, as measured by wing length, and thermal tolerance, as measured by the time to immobilisation at high temperatures (“thermal knockdown”), in populations of the mosquito Aedes sierrensis collected from across a large latitudinal climate gradient spanning 1300 km (34–44° N).

We find that mosquitoes collected from lower latitudes and warmer climates were more tolerant of high temperatures than those collected from higher latitudes and colder climates. Moreover, body size increased with latitude and decreased with temperature, a pattern consistent with James' rule, which appears to be a result of plasticity rather than genetic variation.

Our results suggest that warmer environments produce smaller and more thermally tolerant populations.
Pruned tea biomass plays a significant role in functional food production: A review on characterization and comprehensive utilization of abandon‐plucked fresh tea leaves
Authors: Liang Shuang , Gao Ying , Granato Daniel , Ye Jian‐Hui , Zhou Weibiao , Yin Jun‐Feng , Xu Yong‐Quan 
Published: July 2024

AbstractTea is the second largest nonalcoholic beverage in the world due to its characteristic flavor and well‐known functional properties in vitro and in vivo. Global tea production reaches 6.397 million tons in 2022 and continues to rise. Fresh tea leaves are mainly harvested in spring, whereas thousands of tons are discarded in summer and autumn. Herein, pruned tea biomass refers to abandon‐plucked leaves being pruned in the non‐plucking period, especially in summer and autumn. At present, no relevant concluding remarks have been made on this undervalued biomass. This review summarizes the seasonal differences of intrinsic metabolites and pays special attention to the most critical bioactive and flavor compounds, including polyphenols, theanine, and caffeine. Additionally, meaningful and profound methods to transform abandon‐plucked fresh tea leaves into high‐value products are reviewed. In summer and autumn, tea plants accumulate much more phenols than in spring, especially epigallocatechin gallate (galloyl catechin), anthocyanins (catechin derivatives), and proanthocyanidins (polymerized catechins). Vigorous carbon metabolism induced by high light intensity and temperature in summer and autumn also accumulates carbohydrates, such as soluble sugars and cellulose. The characteristics of abandon‐plucked tea leaves make them not ideal raw materials for tea, but suitable for novel tea products like beverages and food ingredients using traditional or hybrid technologies such as enzymatic transformation, microbial fermentation, formula screening, and extraction, with the abundant polyphenols in summer and autumn tea serving as prominent flavor and bioactive contributors.
Review of SNP assays for disaster victim identification: Cost, time, and performance information for decision‐makers
Authors: Gettings Katherine Butler , Tillmar Andreas , Sturk‐Andreaggi Kimberly , Marshall Charla 
Published: July 2024

AbstractIn mass disaster events, forensic DNA laboratories may be called upon to quickly pivot their operations toward identifying bodies and reuniting remains with family members. Ideally, laboratories have considered this possibility in advance and have a plan in place. Compared with traditional short tandem repeat (STR) typing, single nucleotide polymorphisms (SNPs) may be better suited to these disaster victim identification (DVI) scenarios due to their small genomic target size, resulting in an improved success rate in degraded DNA samples. As the landscape of technology has shifted toward DNA sequencing, many forensic laboratories now have benchtop instruments available for massively parallel sequencing (MPS), facilitating this operational pivot from routine forensic STR casework to DVI SNP typing. Herein, we present the commercially available SNP sequencing assays amenable to DVI, we use data simulations to explore the potential for kinship prediction from SNP panels of varying sizes, and we give an example DVI scenario as context for presenting the matrix of considerations: kinship predictive potential, cost, and throughput of current SNP assay options. This information is intended to assist laboratories in choosing a SNP system for disaster preparedness.
Macauba (Acrocomia aculeata) pulp oil reduces fat accumulation and enhances the lifespan of Caenorhabditis elegans at low temperatures via fat‐1‐ and fat‐7‐dependent pathway
Authors: Ana Cíntia Tomaz Santʼ , Ju Jaehyun , de Barros Frederico Augusto Ribeiro , Kim Kee‐Hong 
Published: July 2024

AbstractMacauba (Acrocomia aculeata) is a Brazilian palm tree whose oil in the pulp is rich in oleic acid and carotenoids. However, its physiological function remains unknown. This study aimed to investigate the effects of macauba pulp oil (MPO) on the metabolic link between lipid metabolism and lifespan using Caenorhabditis elegans (C. elegans). C. elegans were treated with 5.0 mg/mL of MPO for analyzing triglyceride and glycerol accumulation, fatty acid profile, gene expression of lipid and oxidative metabolism proteins under cold (4°C) stress conditions, and lifespan analysis under stress conditions such as cold (4°C), heat (37°C), and oxidative (paraquat) stress. MPO significantly suppressed fat accumulation and increased glycerol (a lipolysis index) and the lifespan of C. elegans at low temperature (4°C). This was accompanied by decreased mRNA levels of the genes involved in lipogenesis (spb‐1 and pod‐2) and increased levels of the genes involved in fatty acid β‐oxidation (acs‐2 and nhr‐49) and fat mobilization genes (hosl‐1 and aak‐2). Additionally, MPO treatment modulated fatty acid pools in C. elegans at low temperatures in that MPO treatment decreased saturated fatty acid levels and shifted the fatty acid profile to long‐chain fatty acids. Moreover, the effect of MPO on fat accumulation at low temperatures was abolished in fat‐7 mutants, whereas both fat‐1 and fat‐7 contribute, at least in part, to MPO‐elevated survival of C. elegans under cold conditions.Practical ApplicationThe results obtained in the present study may contribute to the understanding of the health benefits of consuming macauba pulp oil and consequently stimulate economic growth and the industrial application of this new type of oil, which may result in the creation of new jobs and increased value of small producers.
Changes in the recent three decades and survey on the current status of surgical treatment for esophageal cancer in China
Authors: Li Yong , Liu Wei‐Xin , Qi Ling , Li Yin , Liu Jun‐Feng , Fu Jian‐Hua , Han Yong‐Tao , Fang Wen‐Tao , Yu Zhen‐Tao , Chen Ke‐Neng , Mao You‐Sheng 
Published: July 2024

AbstractBackgroundTo review the changes and survey on status quo of the surgical treatment for esophageal cancer in China. The differences in diagnosis and treatment for esophageal cancer among hospitals in different regions across China were also investigated.MethodsWe sent questionnaires to 46 hospitals across China, investigating the volume of esophageal cancer surgeries, surgical procedures, and perioperative management under the guidance of esophageal surgery chiefs.ResultsA total of 46 questionnaires were sent out and collected. The survey results showed that in the past 5 years, the volume of surgeries for esophageal cancer remained stable by 23.9% of those hospitals, increased by 30.4%, and decreased by 45.7%. Of those patients treated by surgery, 19.1% were in the early stages, and 80.9% were in locally advanced stages. In terms of surgical procedures, 73.4% of the patients were treated by minimally invasive surgery and 85.7% of esophageal substitutes were a gastric conduit, 93.1% of the substitutes were pulled to the neck through the esophageal bed. For the lymph node dissection, 78.5% of the patients had a complete two‐field lymph node dissection including the para‐recurrent laryngeal nerve lymph nodes. Of the patients with neoadjuvant therapy, 53.5% received chemotherapy or chemotherapy plus immunotherapy (47.0%), and 43.5% had chemoradiation.ConclusionsCurrently, in China, minimally invasive surgery‐oriented multimodality treatment, including complete two‐field lymph node dissection, has become the standard approach for esophageal cancer management. Over the past decade, this standardized approach has significantly improved prognosis compared to previous decades.
Study of pediatric appendicitis scores and management strategies: A prospective observational feasibility study
Authors: Lee Wei Hao , O'Brien Sharon , McKinnon Elizabeth , Collin Michael , Dalziel Stuart R. , Craig Simon S. , Borland Meredith L. 
Published: July 2024

AbstractObjectiveThe objective was to investigate the feasibility of prospectively validating multiple clinical prediction scores (CPSs) for pediatric appendicitis in an Australian pediatric emergency department (ED).MethodsA literature search was conducted to identify potential CPSs and a single‐center prospective observational feasibility study was performed between November 2022 and May 2023 to evaluate the performance of identified CPSs. Children 5–15 years presenting with acute right‐sided or generalized abdominal pain and clinician suspicion of appendicitis were included. CPSs were calculated by the study team from prospectively clinician‐collected data and/or review of medical records. Accuracy of CPSs were assessed by area under the receiver operating characteristic curve (AUC) and proportions correctly identifiable as either low‐risk or high‐risk with the best performing CPS compared to clinician gestalt. Final diagnosis of appendicitis was confirmed on histopathology or by telephone/email follow‐up for those discharged directly from ED.ResultsThirty CPSs were identified in the literature search and 481 patients were enrolled in the study. A total of 150 (31.2%) patients underwent appendectomy with three (2.0%) having a normal appendix on histopathology. All identified CPSs were calculable for at least 50% of the patient cohort. The pediatric Appendicitis Risk Calculator for pediatric EDs (pARC‐ED; n = 317) was the best performing CPS with AUC 0.90 (95% confidence interval [CI] 0.86–0.94) and specificity 99.0% (95% CI 96.4%–99.7%) in diagnosing high‐risk cases and a misclassification rate of 4.5% for low‐risk cases.ConclusionsThe study identified 30 CPSs that could be validated in a majority of patients to compare their ability to assess risk of pediatric appendicitis. The pARC‐ED had the highest predictive accuracy and can potentially assist in risk stratification of children with suspected appendicitis in pediatric EDs. A multicenter study is now under way to evaluate the potential of these CPSs in a broader range of EDs to aid clinical decision making in more varied settings.
Sex differences in self‐harm and suicide in young autistic adults
Authors: Hull Laura , Stark Isidora , Lundberg Michael , Ahlqvist Viktor H. , Nordström Selma Idring , Ohlis Anna , Hadlaczky Gergö , Rai Dheeraj , Magnusson Cecilia 
Published: July 2024

AbstractIntroductionBoth suicide and self‐harm are disproportionately common in autistic people. Sex differences in risk of self‐harm and suicide are observed in the general population, but findings are mixed for autistic people. Self‐cutting may be a particularly risky self‐harm behaviour for suicide in autistic people. We aimed to explore sex differences and differences in method of self‐harm in the association between self‐harm and suicide in autistic and non‐autistic adolescents and young adults.MethodsWe used a total population register of 2.8 million Swedish residents. Participants were followed from age 12 until December 2021 for medical treatment because of self‐harm, and death from suicide. We used Cox proportional hazard regression models to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) for risk of death from suicide following self‐harm, and Relative Excessive Risk due to Interaction (RERI) to explore the interaction between self‐harm and autism in females and males.ResultsWe identified 85,143 autistic individuals (31,288 female; 53,855 male) and 2,628,382 non‐autistic individuals (1,286,481 female; 1,341,901 male) aged 12–37 years. Incidence of suicide following self‐harm was higher in autistic males (incidence per 100,000 risk‐years = 169.0 [95% CI 135.1, 211.3]) than females (125.4 [99.4, 158.3]). The relative risk was higher for autistic females (HR 26.1 [95% CI 20.2, 33.7]) than autistic males (12.5 [9.9, 15.8]). An additive effect of both autism and self‐harm was observed in both females (RERI = 9.8) and males (2.0). Autistic individuals who self‐harmed through cutting were at greatest risk of death from suicide (HR 25.1 [17.9, 35.2]), compared to other methods.ConclusionAutistic males and females are at increased risk of death from suicide following severe self‐harm, particularly self‐cutting.