bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Role of Cognition, Affective Symptoms, and Apathy in Treatment Adherence with Noninvasive Home Mechanical Ventilation in Myotonic Dystrophy
Authors: Vosse Bettine A.H. , de Jong Jasmijn , la Fontaine Leandre A. , Horlings Corinne G.C. , van Kuijk Sander M.J. , Cobben Nicolle A.M. , Domensino Anne-Fleur , van Heugten Caroline , Faber Catharina G. 
Published: July 2024

Background: Chronic respiratory failure often occurs in myotonic dystrophy type 1 (DM1) and can be treated with noninvasive home mechanical ventilation (HMV). Treatment adherence with HMV is often suboptimal in patients with DM1, but the reasons for that are not well understood. Objective: The aim of this exploratory study was to gain insight in the prevalence of mild cognitive impairment, affective symptoms, and apathy and to investigate their role in HMV treatment adherence in DM1. Methods: The Montreal Cognitive Assessment (MoCA), the Hospital Anxiety and Depression Scale (HADS), and the Apathy Evaluation Scale (AES) were used to assess cognition, affective symptoms, and apathy in DM1 patients that use HMV. Patients with low treatment adherence (average daily use HMV <5 h or <80% of the days) were compared with patients with high treatment adherence (average daily use of HMV≥5 h and ≥80% of the days). Results: Sixty patients were included. Abnormal scores were found in 40% of the total group for the MoCA, in 72–77% for the AES, and in 18% for HADS depression. There was no difference between the high treatment adherence group ( n = 39) and the low treatment adherence group ( n = 21) for the MoCA, AES, and HADS depression. The HADS anxiety was abnormal in 30% of the total group, and was significantly higher in the low treatment adherence group ( p = 0.012). Logistic regression analysis revealed that a higher age and a higher BMI were associated with a greater chance of high treatment adherence. Conclusions: This exploratory study showed that cognitive impairment and apathy are frequently present in DM1 patients that use HMV, but they are not associated with treatment adherence. Feelings of anxiety were associated with low treatment adherence. Higher age and higher BMI were associated with high treatment adherence with HMV.
Turkish cross-cultural adaptation, construct validity, and reliability of the treatment expectations in chronic pain scale
Authors: Aytar Ayça , Altintas Atahan , Gercek Hasan , Sarak Hazal , Pagé M. Gabrielle , Aytar Aydan 
Published: July 2024

BACKGROUND: Measuring treatment expectations using the Treatment Expectations in Chronic Pain (TEC) scale has the potential to help clinicians and researchers better understand the role that treatment expectations play within the framework of multimodal pain management settings. OBJECTIVE: The purpose of this study is to determine the cross-cultural adaptation, construct validity and reliability of the TEC Scale in the Turkish language. METHODS: The study included 191 volunteers aged 22–65 with chronic musculoskeletal diseases. This study composed of a six-stage cross-cultural adaptation process, which included translation, translation synthesis, back-translation, expert committee review, pre-testing and documentation submission. The Positivity Scale and Illness Cognition Questionnaire were used to measure convergent validity while the Hospital Anxiety and Depression Scale was used to test divergent validity. The psychometric properties of the Turkish version of the TEC scale was examined by confirmatory factor analysis (CFA). Scale’s internal consistency was examined using Cronbach’s alpha. Pearson correlation coefficients were utilized to evaluate both convergent and divergent validity. The significance level was set at p < .05. RESULTS: The results of the CFA showed that factor structure of predicted subscale fitted well the data (x2/df = 3,07;CFI = 0,91,IFI = 0,91 TLI = 0,87,RMSEA = 0,10). The results of the CFA indicated that factor structure of ideal subscale fitted well with the data (x2/df = 2,38;CFI = 0,92,IFI = 0,93,TLI = 0,90,RMSEA = 0,08). Both subscales of the TEC were strongly correlated. The predicted subscale had moderate relationships to depression, anxiety, and positivity (r = -0.37 to r = 0.55) but poor correlations with measures of acceptance, perceived benefits and helplessness (r = -0.24 to 0.35). The ideal subscale had moderate correlations with measures of positivity (r = 0.36) and depression (r = -0.38) but poor correlations with measures of acceptance, perceived benefits helplessness and anxiety (r = 0.14). CONCLUSIONS: The Turkish version of the TEC scale is acceptable, valid, and reliable for use in Turkish patients with chronic musculoskeletal pain in physiotherapy outpatient practice.
Perancangan dan Pembangunan Sistem Informasi Geografis Pemetaan Lokasi Penyedia Jasa Servis Perangkat Komputer di Wilayah Kota Tangerang Selatan Berbasis Web
Authors: Pamungkas Abiyan Pasya , Yulianti Yulianti 
Published: July 2024

Dengan meningkatnya kegiatan belajar dari rumah dan bekerja dari rumah selama masa pandemi COVID-19 tentu berpengaruh juga pada peningkatan pengguna perangkat komputer seperti laptop dan desktop PC. Penyedia jasa servis perangkat komputer merupakan jasa yang banyak diminati terutama oleh para pengguna perangkat komputer yang baru menggunakan perangkat komputer di masa pandemi ini namun, sama seperti pelaku usaha lainnya pelaku UMKM jasa servis perangkat komputer juga mengalami penurunan jumlah pelanggan yang mengakibatkan penurunan omset di awal pandemi COVID-19 karena kurangnya kegiatan promosi di masa pandemi oleh pelaku usaha jasa servis perangkat komputer. Dengan adanya permasalahan tersebut, maka perancangan sistem informasi geografis pemetaan lokasi-lokasi penyedia jasa servis perangkat komputer cukup memungkinkan guna memberi kemudahan kepada masyarakat yang ingin melakukan perbaikan pada perangkat komputernya dan membantu para penyedia jasa servis perangkat komputer dalam mempromosikan jasanya, pengembangan sistem informasi geografis ini menggunakan metode Waterfall, dan untuk bahasa pemrogramannya menggunakan PHP dan Database MySQL.
المنمنمات العربية -المنمنمات السياسية لصقلية إنموذجاً-
Authors: عكلة أ.م.د منال حسن 
Published: July 2024

المنمنمات هي عبارة عن رسوم توضيحية، انتشرت في مجموعة من المؤلفات، وكان الغرض منها، تسهيل فهم النصوص المكتوبة أو توضيحها، على شكل لوحة فنية تصويرية، ازدهرت في بداية الامر في العالم الاسلامي في فترة الفتوحات، ولما نشطت عملية الفتوحات الاسلامية التقت مع الدول الاوربية لاسيما البلدان التي حكمها العرب المسلمون ومنها صقلية، التي حكمها الفاطميون(297هـ-484هـ/910-1091م)[ حكم الفاطميون صقلية عن طريق ولاتهم الكلبيين وغيرهم لمدة قرنين بعد ان انشأوا اسطولاً ضخماً هدفه حماية البلاد من الهجمات البيزنطينية ثم دافع عنها بعد ذلك في الحروب الصليبية، كما كان هدفهم نشر المذهب الاسماعيلي وتحقيق العديد من طموحاتهم خلال مدة وجيزة.فحكم خلال تلك الفترة ولاة من قبل الفاطميين في صقلية فكان عصر الولاة (296-336هـ/908م-947م) ، ثم حكم الامراء الكلبيين، بأسم الدولة الفاطمية] (الحموي، ١٩٩٥، صفحة 392) (الادريسي، 1989، صفحة 762).
وامتاز الفنان العربي في صقلية ببصمته المميزة في هذا الفن مما ادى الى ازدهاره في بقية الدول، على الرغم من بساطة الاسلوب التي اتسمت به فن المنمنمات في البدء، الا انها تطورت مع مرور الزمن واصبحت تمتاز بالواقعية والتعبيرية، فهو فن يدعو الى استلهام الماضي واعادة احياءه.
عُد فن المنمنمات السياسية واحد من الموضوعات المهمة التي سلطنا الضوء عليها في هذا البحث، لما لها من اهمية تاريخية، كون ان المنمنمات ذات الموضوعات السياسية أعُتبرت كوثيقة يتم الاعتماد عليها في المراجع التاريخية والسياسية وغيرها.

مشكلة البحث كانت في صعوبة الحصول على المعلومات عن صقلية لاسيما المترجمة منها عن فترة الحكم الاسلامي وما بعده، لقلة المصادر المترجمة عنها. بينما اهمية البحث تتجلى في جمالية اعادة استخدام هذا الفن في المؤسسات التعليمية والعمرانية لأهميتها التاريخية كونها تعكس حضارة وتاريخ بلد بأسره والجمالية كونها ذا قيمة فنية عالية في الالوان والافكار والرسومات وغيرها،وقد تم استخدام المنهج التاريخي والمنهج الوصفي في هذه الدراسة. وقد تم اختيار هذا الموضوع كونه يعكس اهمية المنمنمات السياسية ودورها في الحصول على المعلومات التاريخية من خلالها.
Kepemimpinan Koperasi Syariah Masa Depan
Authors: Hurriyaturrohman Hurriyaturrohman 
Published: July 2024

Secara implementatif, Koperasi syariah baik sebagai gerakan ekonomi rakyat maupun sebagai badan usaha berperan serta untuk mewujudkan masyarakat yang makmur, sejahtera berdasarkan UUD 1945 dan berdasarkan Pancasila dalam tata kelola perekonomian Nasional yang disusun sebagai usaha bersama berdasarkan atas asas kekeluargaan dan syariah Islam yaitu Al-Quran dan As-Sunnah dengan saling tolong menolong (ta'awun) dan saling menguatkan (takaful) dan dilandasi dengan semangat gotong-royong.Peran dan fungsi kepemimpinan koperasi syariah guna menghadapi persaingan usaha masa depan harus tetap memperhatikan kaidah dasar organisasi koperasi yang memposisikan sebagai badan usaha yang beranggotaan orang-seorang atau badan hukum koperasi dengan melandasi kegiatannya berdasarkan prinsip koperasi syariah sekaligus sebagai gerakan ekonomi rakyat yang berdasarkan atas asas kekeluargaan. Keyword: Koperasi syariah, Siddiq, amanah, Tabliqh, Fathanah
SIMULASI SAHAM PADA JAKARTA STOCK EXCHANGE DESEMBER 2005
Authors: Nurhayati Immas 
Published: July 2024

Sifat ketidakpastian keputusan investasi di masa mendatang disebabkan adanyaresiko yang dihadapi investor dalam upaya mendapatkan return (imbal hasil). Diversifikasi saham merupakan salah satu upaya untuk meminimumkan tingkat resiko. Mengapa pemodal tertarik untuk melakukan diversifikasi dan membentuk portofolio investasi? Jawaban klasiknya adalah bahwa diversifikasi (atau pembentukan portofolio) akan mengurangi resiko.Pepatah asing mengatakan “smart investor do not put all their eggs in one basket “. Penulis mencoba mensimulasikan secara sederhana bagaimana berinvestasi dalam saham dengan menerapkan berbagai teori mengenai pembentukan portofolio sehingga investasi dalam saham memberikan keuntungan bagi investor. Data yang digunakan dalamstudi ini merupakan data sekunder yang diperoleh dari publikasi Jakarta Stock Exchange selama periode Oktober sampai Desember 2005. Hasil simulasi, dengan modal awal sebesar satu milyar (1.000.000.000) yang terebar dalam beberapa sekuritas memberikan return kumulatif sebesar 1.202.700.000 atau sekitar 20,31%.
Evolutionarily conserved enhancer-associated features within the MYEOV locus suggest a regulatory role for this non-coding DNA region in cancer
Authors: Davidson Brigid S. A. , Arcila-Galvis Juliana Estefania , Trevisan-Herraz Marco , Mikulasova Aneta , Brackley Chris A. , Russell Lisa J. , Rico Daniel 
Published: July 2024

The myeloma overexpressed gene (MYEOV) has been proposed to be a proto-oncogene due to high RNA transcript levels found in multiple cancers, including myeloma, breast, lung, pancreas and esophageal cancer. The presence of an open reading frame (ORF) in humans and other primates suggests protein-coding potential. Yet, we still lack evidence of a functional MYEOV protein. It remains undetermined how MYEOV overexpression affects cancerous tissues. In this work, we show that MYEOV has likely originated and may still function as an enhancer, regulating CCND1 and LTO1. Firstly, MYEOV 3′ enhancer activity was confirmed in humans using publicly available ATAC-STARR-seq data, performed on B-cell-derived GM12878 cells. We detected enhancer histone marks H3K4me1 and H3K27ac overlapping MYEOV in multiple healthy human tissues, which include B cells, liver and lung tissue. The analysis of 3D genome datasets revealed chromatin interactions between a MYEOV-3′-putative enhancer and the proto-oncogene CCND1. BLAST searches and multi-sequence alignment results showed that DNA sequence from this human enhancer element is conserved from the amphibians/amniotes divergence, with a 273 bp conserved region also found in all mammals, and even in chickens, where it is consistently located near the corresponding CCND1 orthologues. Furthermore, we observed conservation of an active enhancer state in the MYEOV orthologues of four non-human primates, dogs, rats, and mice. When studying this homologous region in mice, where the ORF of MYEOV is absent, we not only observed an enhancer chromatin state but also found interactions between the mouse enhancer homolog and Ccnd1 using 3D-genome interaction data. This is similar to the interaction observed in humans and, interestingly, coincides with CTCF binding sites in both species. Taken together, this suggests that MYEOV is a primate-specific gene with a de novo ORF that originated at an evolutionarily older enhancer region. This deeply conserved putative enhancer element could regulate CCND1 in both humans and mice, opening the possibility of studying MYEOV regulatory functions in cancer using non-primate animal models.
Genome-wide sRNA and mRNA transcriptomic profiling insights into carbapenem-resistant Acinetobacter baumannii
Authors: Wei Yong , Xin Xuli , Zhang Jiachun , Liao Qifeng , Rong Yan , Zhong Ying , Zhao Meiying , Ma Jianping , He Song 
Published: July 2024

IntroductionAcinetobacter baumannii (AB) is rising as a human pathogen of critical priority worldwide as it is the leading cause of opportunistic infections in healthcare settings and carbapenem-resistant AB is listed as a “super bacterium” or “priority pathogen for drug resistance” by the World Health Organization.MethodsClinical isolates of A. baumannii were collected and tested for antimicrobial susceptibility. Among them, carbapenem-resistant and carbapenem-sensitive A. baumannii were subjected to prokaryotic transcriptome sequencing. The change of sRNA and mRNA expression was analyzed by bioinformatics and validated by quantitative reverse transcription-PCR.ResultsA total of 687 clinical isolates were collected, of which 336 strains of A. baumannii were resistant to carbapenem. Five hundred and six differentially expressed genes and nineteen differentially expressed sRNA candidates were discovered through transcriptomic profile analysis between carbapenem-resistant isolates and carbapenem-sensitive isolates. Possible binding sites were predicted through software for sRNA21 and adeK, sRNA27 and pgaC, sRNA29 and adeB, sRNA36 and katG, indicating a possible targeting relationship. A negative correlation was shown between sRNA21 and adeK (r = -0.581, P = 0.007), sRNA27 and pgaC (r = -0.612, P = 0.004), sRNA29 and adeB (r = -0.516, P = 0.020).DiscussionThis study preliminarily screened differentially expressed mRNA and sRNA in carbapenem-resistant A. baumannii, and explored possible targeting relationships, which will help further reveal the resistance mechanism and provide a theoretical basis for the development of drugs targeting sRNA for the prevention and treatment of carbapenem-resistant A. baumannii infection.
Cross-cultural comparative analysis of student motivation and autonomy in learning: perspectives from Hong Kong and the United Kingdom
Authors: Lo Noble Po-Kan 
Published: July 2024

IntroductionThis research project examines student perspectives on independent learning in the United Kingdom and Hong Kong. Independent learning describes learning undertaken by students outside of standard institutional learning environments. Prior research has suggested that motivations to undertake independent learning and the strategies involved may differ across cultural contexts, institutions, and individual learners.MethodsThis research employs primary qualitative research consisting of interviews with 16 students in Business Studies (eight British and eight Chinese). The study takes a social constructionist approach to better establish the ways in which culture may serve as a mediator for motivation to learn independently and the strategies pursued to this end.ResultsThe study’s findings note key differences in the motivations to complete independent learning across either cohort, as well as distinct conceptualizations of what strategies and practices facilitate effective independent learning.DiscussionThis research highlights significant cultural differences in the motivations, strategies, and skills related to independent learning between students in the United Kingdom and Hong Kong. It also notes the potential for socioeconomic factors, institutional structures, and assessment methods, alongside culture, to contribute to these differences.
Pharmacokinetics and tissue distribution of LN002, a new compound alternative oxidase inhibitor against Cryptosporidium in rats
Authors: Ma Minglang , Zhang Yongxiang , Fang Yanjun , Lu Yixing , Huang Huiguo , Zeng Zhenling , Zeng Dongping 
Published: July 2024

Cryptosporidiosis is considered a crucial zoonotic disease caused by widely distributing parasitic protozoa called Cryptosporidium spp. Nitazoxanide is the only FDA-approved drug but is only effective with a good immune response of the host. In addressing this unmet medical need, we previously identified a compound, namely, LN002, as a potent alternative oxidase inhibitor against cryptosporidiosis. To illustrate the pharmacokinetics, absolute bioavailability, and tissue distribution of LN002 in rats, rapid and sensitive high-performance liquid chromatography was developed and validated for the separation and detection of LN002 in plasma, tissue samples, and intestinal contents. In this study, a single dose of oral administration and intravenous injection of LN002 was used to determine the levels of LN002 in plasma, tissue samples, and intestinal contents by UHLC. Results of the study indicated that after intravenous administration of 1 mg/kg LN002, the AUC0–24 h, T1/2,Vd, and Cl were 7024.86 h·ng/mL, 10.91 h, 1.69 L/kg, and 0.11 L/h/kg, respectively. After oral administration of a single dosage of 100, 200, and 400 mg/kg LN002, the Tmax, Cmax, AUC0–24 h, T1/2, F, Vd, and Cl/F in plasma of rats were 1 h, 849.88–4033.21 ng/mL, 2280.41–7498.10 h·ng/mL, 17.96–18.83 h, 0.27%–0.32%, 581.54–869.21 L/kg, and 25.97–39.00 L/h/kg, respectively. After oral administration of 200 mg/kg, LN002 was extensively distributed in the main tissues of rats, and massive amounts of LN002 were distributed in the intestine and intestinal contents, indicating its potential as an effective anti-Cryptosporidium compound. After oral administration of a single dosage of 200 mg/kg, LN002 has a low bioavailability and high levels in the intestine, which is crucial for the safe and effective treatment of cryptosporidiosis. Overall, the results of this study provide valuable data support for the future study of LN002.
Naringin and temozolomide combination suppressed the growth of glioblastoma cells by promoting cell apoptosis: network pharmacology, in-vitro assays and metabolomics based study
Authors: Bisht Priya , Prasad Surendra Rajit , Choudhary Khushboo , Pandey Ruchi , Aishwarya Dande , Aravind Vulli , Ramalingam Peraman , Velayutham Ravichandiran , Kumar Nitesh 
Published: July 2024

Introduction: Glioblastoma, which affects a large number of patients every year and has an average overall lifespan of around 14.6 months following diagnosis stands out as the most lethal primary invasive brain tumor. Currently, surgery, radiation, and chemotherapy with temozolomide (TMZ) are the three major clinical treatment approaches. However, the ability to treat patients effectively is usually limited by TMZ resistance. Naringin, a bioflavonoid with anti-cancer, antioxidant, metal-chelating, and lipid-lowering effects, has emerged as a promising therapeutic option.Methods: To explore the targets and pathways of naringin and TMZ in glioblastoma network pharmacology, cell line-based ELISA, flow cytometry, immunocytochemistry, western blotting, and LC-HRMS based metabolomics study were used.Results: The findings through the network pharmacology suggested that the key targets of naringin in the chemosensitization of glioblastoma would be Poly [ADP-ribose] polymerase 1 (PARP-1), O-6-Methylguanine-DNA Methyltransferase (MGMT), and caspases. The functional enrichment analysis revealed that these targets were significantly enriched in important pathways such as p53 signaling, apoptosis, and DNA sensing. Further, the results of the in-vitro study in U87-MG and T98-G glioblastoma cells demonstrated that TMZ and naringin together significantly reduced the percentage of viability and inhibited the DNA repair enzymes PARP-1 and MGMT, and PI3K/AKT which led to chemosensitization and, in turn, induced apoptosis, which was indicated by increased p53, caspase-3 expression and decreased Bcl2 expression. Additionally, a metabolomics study in T98-G glioblastoma cells using liquid chromatography high-resolution mass spectrometry (LC-HRMS) revealed downregulation of C8-Carnitine (−2.79), L-Hexanoylcarnitine (−4.46), DL-Carnitine (−2.46), Acetyl-L-carnitine (−3.12), Adenine (−1.3), Choline (−2.07), Propionylcarnitine (−1.69), Creatine (−1.33), Adenosine (−0.84), Spermine (−1.42), and upregulation of Palmitic Acid (+1.03) and Sphingosine (+0.89) in the naringin and TMZ treatment groups.Discussion: In conclusion, it can be said that naringin in combination with TMZ chemosensitized TMZ antiglioma response and induced apoptosis in tumor cells.
Noether Symmetries of the Triple Degenerate DNLS Equations
Authors: Camci Ugur 
Published: July 2024

In this paper, Lie symmetries and Noether symmetries along with the corresponding conservation laws are derived for weakly nonlinear dispersive magnetohydrodynamic wave equations, also known as the triple degenerate derivative nonlinear Schrödinger equations. The main goal of this study is to obtain Noether symmetries of the second-order Lagrangian density for these equations using the Noether symmetry approach with a gauge term. For this Lagrangian density, we compute the conserved densities and fluxes corresponding to the Noether symmetries with a gauge term, which differ from the conserved densities obtained using Lie symmetries in Webb et al. (J. Plasma Phys. 1995, 54, 201–244; J. Phys. A Math. Gen. 1996, 29, 5209–5240). Furthermore, we find some new Lie symmetries of the dispersive triple degenerate derivative nonlinear Schrödinger equations for non-vanishing integration functions Ki(t) (i=1,2,3).
UJI AKTIVITAS ANTIOKSIDAN DAN PENENTUAN NILAI SUN PROTECTION FACTOR (SPF) DARI FRAKSI DAUN VIOLET (Viola odorata L.)
Authors: Anjani Marshela , Wardana Fendi Yoga , Ardianto Nanang , Istiqomah Maria 
Published: July 2024

Paparan radiasi sinar UV dalam waktu lama dapat memicu efek berbahaya pada kulit manusia, seperti kerutan dan kanker kulit. Dampak buruk tersebut dapat diminimalisir dengan penggunaan tabir surya sebagai pelindung sinar UV. Daun violet (Viola odorata L.) mempunyai kandungan senyawa flavonoid yang berpotensi sebagai antioksidan sekaligus zat aktif tabir surya. Tujuan penelitian ini adalah untuk mengetahui aktivitas antioksidan dan mengukur nilai Sun Protection Factor (SPF) pada fraksi daun violet (Viola odorata L.). Penelitian ini dilakukan di Laboratorium Farmakognosi dan Kimia ITSK RS dr. Soepraoen pada bulan Agustus sampai September 2023. Metode ekstraksi yang digunakan adalah maserasi yang kemudian dilanjutkan dengan fraksinasi. Penentuan aktivitas antioksidan menggunakan metode DPPH (1,1-diphenyl-2-picrylhydrazyl) dan penentuan aktivitas tabir surya menggunakan perhitungan Sun Protection Factor (SPF). Pengukuran nilai IC50 sebagai pengukur aktivitas antioksidan dengan spektrofotometri UV-Vis yang panjang gelombangnya 517 nm, sedangkan spektrofotometri UV-Vis yang digunakan untuk menentukan nilai SPF pada rentang panjang gelombang 290-320 nm. Hasil penelitian menunjukkan aktivitas antioksidan yang rendah dari fraksi-fraksi daun violet (Viola odorata L.), dengan nilai IC50 sebesar 1690 µg/mL untuk fraksi n-heksana, 1880 µg/mL untuk fraksi etil asetat dan 2130 µg/mL untuk fraksi etanol. Kategori perlindungan minimal pada konsentrasi 250 ppm ditunjukkan oleh nilai SPF fraksi n-heksana dan etil asetat, yaitu masing-masing 2,142 dan 2,807. Pada konsentrasi 250 ppm, nilai SPF fraksi etanol adalah 12,589, masuk dalam kategori perlindungan maksimal.