bluuebunny/crossref_metadata_2025_split huggingface dataset:
Morphological diversity and genetic regulation of inflorescence abscission zones in grasses
Authors: Doust Andrew N. , Mauro‐Herrera Margarita , Francis Amie D. , Shand Laura C. 
Published: October 2014

• Premise of the study: Variation in how seeds are dispersed in grasses is ecologically important, and selection for dispersal mechanisms has produced a great variety of dispersal structures (diaspores). Abscission (“shattering”) is necessary in wild grasses, but its elimination by selection on nonshattering mutants was a key component of the domestication syndrome in cereal grasses. A key question is whether a common genetic pathway controls abscission in wild grasses, and, if so, what genes in that pathway may have been selected upon during domestication. We summarize morphological and genetic information on abscission zones and disarticulation patterns in grasses and identify hypotheses to test the likelihood of a common genetic pathway.• Methods: Morphological data on abscission zones for over 10000 species of grasses were tabulated and analyzed using a tribal phylogeny of the grasses. The genomic location of quantitative trait loci (QTLs) and orthologs of genes controlling shattering were compared across species to ascertain whether the same loci might control shattering in different grass lineages.• Results and conclusions: The simple trait of nonshattering is derived from a great diversity of shattering phenotypes. Several sets of QTLs from multiple species are syntenic yet many are not. Genes known to be involved in shattering in several species were found to have orthologs that sometimes colocalized with QTLs in different species, adding support to the hypothesis of retention of a common genetic pathway. These results are used to suggest a research plan that could test the common genetic pathway model more thoroughly.
Idéal de séance ?
Authors: Dargent Fanny 
Published: October 2014

L’article propose d’envisager la spécificité des psychothérapies à l’adolescence à partir de deux cas cliniques. Le premier évoque une forme « d’idéal d’être là » où le clinicien est un interlocuteur bienveillant accompagnant les remaniements intrapsychiques de l’adolescent. Dans le second, le désordre familial, entre autres, entrave la rencontre avec l’adolescent dans l’ici et maintenant de la séance.
Conséquences psychiques induites par « l'effet-mère »
Authors: Givre Philippe 
Published: October 2014

Les développements conceptuels apportés par D. Guyomard dans son ouvrage L’effet-mère s’avèrent précieux pour enrichir les notions explicitement pensées dans le cadre des processus adolescents. Ainsi, l’archaïque pubertaire viendrait réveiller, interroger la qualité du « narcissisme du lien » : lien initial de la relation mère-fille, et les conditions de la construction de l’objet mère et de sa perte. Sont envisagés le risque d’une mélancolisation du lien à l’objet et les répercussions au niveau du processus identificatoire, notamment pour la transmission du féminin entre mère et fille.
L'apprentissage du raisonnement clinique infirmier par vignette clinique courte : étude exploratoire
Authors: Perrier Charlotte 
Published: October 2014

Introduction : l’enseignement du raisonnement clinique infirmier (RCI) est une préoccupation importante des formateurs en sciences infirmières depuis plusieurs années. Contexte : les étudiantes en sciences infirmières éprouvent des difficultés à formuler des hypothèses cliniques. Pourtant, la formulation d’hypothèses constitue une étape déterminante du RCI. Objectif : l’étude visait à documenter la capacité d’étudiantes de troisième année au baccalauréat en sciences infirmières à formuler des hypothèses cliniques durant une activité d’apprentissage par vignette clinique courte (AVCC). Méthode : pour cette étude qualitative exploratoire, dix-sept étudiantes ont été recrutées par convenance et divisées en quatre groupes selon leurs disponibilités. Chaque groupe a participé une fois à l’activité. L’observation participante, l’enregistrement audio-vidéo et un questionnaire auto-administré ont servi à collecter les données. Les stratégies de RCI décrites par Fonteyn (1998) ont servi de cadre théorique pour guider l’analyse. Résultats : les résultats suggèrent que l’AVCC stimule la formulation d’hypothèses cliniques et la réactivation des connaissances antérieures. Discussion : plus de recherches sont nécessaires afin de vérifier si l’activité pourrait être employée auprès d’étudiantes en début de formation. Conclusion : cette activité pourrait donc être utile en complément d’autres activités éducatives pour favoriser le développement du RCI chez les étudiantes en sciences infirmières.
Apprendre à coopérer pour promouvoir la santé
Authors: Dollet Agnès 
Published: October 2014

La coopération sanitaire et sociale permet la prise en charge des usagers dans une logique de promotion de la santé. L’IRFSS Auvergne a pour but de favoriser la coopération entre les futurs infirmiers et assistants de service social qu’il forme. L’objectif de ce travail était d’élaborer et de mettre en œuvre un dispositif intégré à la formation des étudiants infirmiers et assistants de service social, leur permettant de développer des aptitudes à coopérer en situation de travail. Une étude réalisée auprès d’infirmiers et d’assistants de service social de terrain a montré que la coopération sanitaire et sociale permet la promotion de la santé, mais que des freins à la coopération subsistent encore. Grâce à cette étude, un dispositif pédagogique adapté aux problématiques de terrain : la « boîte à outils pour apprendre à coopérer » a été créé. Au-delà de ce projet, l’étude a permis un questionnement sur la place de la promotion de la santé dans les formations sanitaires et sociales, l’organisation de la formation continue des professionnels à l’échelle d’un territoire de santé, et la place de la coordination dans la formation des cadres.
L'oralisme, une demande des parents ?
Authors: Bernard Alix 
Published: October 2014

Résumé	L’histoire de l’éducation des sourds est ponctuée de mouvements polémiques entre partisans de la langue orale et tenants de la langue des signes. Les arguments pour défendre l’option oraliste n’ayant cessé de se répéter, on veut s’intéresser ici à ce qui les sous-tend. Une grande part des résistances à l’égard de l’éducation par les signes a pu être attribuée à la supériorité des langues orales, vécues comme facteur d’intégration, mais aussi à une quasi répulsion du geste, situé alors du côté de l’animal et du (...)
La Scène des sourds
Authors: Potte-Bonneville Laurence 
Published: October 2014

Résumé	Créé il y a vingt ans par un groupe de jeunes adultes sourds, l’International Visual Theatre n’est pas une scène de plus. C’est à la fois un acte politique fondateur pour la culture sourde et un laboratoire où se dessinent des dictionnaires, où se crée une pédagogie, où s’invente une écriture.
Les enjeux de l'expertise démocratique
Authors: Glatron Marion 
Published: October 2014

Résumé	L’expertise transplante une parole scientifique dans un champ politique. C’est à la jonction de ces deux sphères, celle du savoir et celle du pouvoir, que se joue une des questions essentielles à l’exercice démocratique : comment peut-on faire des choix ?
culture bougre
Authors: Mangeot Philippe 
Published: October 2014

Résumé	Il y a des phrases auxquelles on fait des bébés dans le dos. On a oublié où on les a trouvées, qui les a formulées, si elles ne se sont pas émoussées avec le temps, si une mémoire défaillante ou accommodante n’en a pas modifié les termes et le sens. « Il n’y aura de communauté gaie que quand elle aura une culture. » Cela sonne comme un aphorisme. Je l’ai longtemps attribué à Foucault. J’en faisais un usage rêveur et distrait. J’ignorais au juste ce qu’elle pouvait vouloir dire, faute de comprendre très bien ce qu’il fallait entendre par « culture ».
Inhibition of Protein Geranylgeranylation Specifically Interferes with CD40-Dependent B Cell Activation, Resulting in a Reduced Capacity To Induce T Cell Immunity
Authors: Shimabukuro-Vornhagen Alexander , Zoghi Shahram , Liebig Tanja M. , Wennhold Kerstin , Chemitz Jens , Draube Andreas , Kochanek Matthias , Blaschke Florian , Pallasch Christian , Holtick Udo , Scheid Christof , Theurich Sebastian , Hallek Michael , von Bergwelt-Baildon Michael S. 
Published: October 2014

Abstract
Ab-independent effector functions of B cells, such as Ag presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection, and graft-versus-host disease. Most current immunosuppressive treatments target T cells, are relatively unspecific, and result in profound immunosuppression that places patients at an increased risk of developing severe infections and cancer. Therapeutic strategies, which interfere with B cell activation, could therefore be a useful addition to the current immunosuppressive armamentarium. Using a transcriptomic approach, we identified upregulation of genes that belong to the mevalonate pathway as a key molecular event following CD40-mediated activation of B cells. Inhibition of 3-hydroxy-3-methylglutaryl CoA reductase, the rate-limiting enzyme of the mevalonate pathway, by lipophilic statins such as simvastatin and atorvastatin resulted in a specific inhibition of B cell activation via CD40 and impaired their ability to act as stimulatory APCs for allospecific T cells. Mechanistically, the inhibitory effect resulted from the inhibition of protein geranylgeranylation subsequent to the depletion of mevalonate, the metabolic precursor for geranylgeranyl. Thus, inhibition of geranylgeranylation either directly through geranylgeranyl transferase inhibitors or indirectly through statins represents a promising therapeutic approach for the treatment of diseases in which Ag presentation by B cells plays a role.
De relatieve zwaarte van wederzijdse verantwoordelijkheid voor teleurstellende effectenleaseresultaten
Authors: Keirse A.L.M. , van Onna A. 
Published: October 2014

De relatieve zwaarte van wederzijdse verantwoordelijkheid voor teleurstellende effectenleaseresultaten
Avonturen in de effectenlease liepen slecht af als gevolg van een samenloop van omstandigheden, waaronder een te gretig winstoogmerk aan de zijde van de financiële aanbieder en een te grote lichtvaardigheid aan de zijde van de afnemende consument. In deze bijdrage wordt de (inmiddels gestandaardiseerde) schadedeling onder de loep genomen die in de rechtspraak is gevolgd op de erkenning van de wederzijdse verantwoordelijkheid in dezen.
Mededingingsrechtelijke aspecten van technologieoverdrachtsovereenkomsten
Authors: Lugard Paul 
Published: October 2014

Mededingingsrechtelijke aspecten van technologieoverdrachtsovereenkomsten
Deze bijdrage gaat in op de gewijzigde groepsvrijstelling inzake technologieovereenkomsten, Verordening 316/2014. De verordening introduceert een aantal significante wijzigingen die van belang zijn bij het redigeren van nieuwe octrooilicentieovereenkomsten en andere overeenkomsten inzake technologieoverdracht en noodzaken tot aanpassingen van bestaande overeenkomsten. De wijzigingen zijn ingegeven door de toename van “patent thickets” en de zorg omtrent de zwakke onderhandelingspositie van kleinere marktpartijen en zien onder meer op “grant back” bepalingen, beëindiging in geval van betwisting van de in licentie gegeven technologie en technologie-pool licenties.
Multipotent Mesenchymal Stromal Cells Synergize With Costimulation Blockade in the Inhibition of Immune Responses and the Induction of Foxp3+ Regulatory T Cells
Authors: Takahashi Tohru , Tibell Annika , Ljung Karin , Saito Yu , Gronlund Anna , Osterholm Cecilia , Holgersson Jan , Lundgren Torbjörn , Ericzon Bo-Göran , Corbascio Matthias , Kumagai-Braesch Makiko 
Published: October 2014

Abstract

Multipotent mesenchymal stromal cell (MSC) therapy and costimulation blockade are two immunomodulatory strategies being developed concomitantly for the treatment of immunological diseases. Both of these strategies have the capacity to inhibit immune responses and induce regulatory T cells; however, their ability to synergize remains largely unexplored. In order to study this, MSCs from C57BL/6 (H2b) mice were infused together with fully major histocompatibility complex-mismatched Balb/c (H2d) allogeneic islets into the portal vein of diabetic C57BL/6 (H2b) mice, which were subsequently treated with costimulation blockade for the first 10 days after transplantation. Mice receiving both recipient-type MSCs, CTLA4Ig, and anti-CD40L demonstrated indefinite graft acceptance, just as did most of the recipients receiving MSCs and CTLA4Ig. Recipients of MSCs only rejected their grafts, and fewer than one half of the recipients treated with costimulation blockade alone achieved permanent engraftment. The livers of the recipients treated with MSCs plus costimulation blockade contained large numbers of islets surrounded by Foxp3+ regulatory T cells. These recipients showed reduced antidonor IgG levels and a glucose tolerance similar to that of naïve nondiabetic mice. Intrahepatic lymphocytes and splenocytes from these recipients displayed reduced proliferation and interferon-γ production when re-exposed to donor antigen. MSCs in the presence of costimulation blockade prevented dendritic cell maturation, inhibited T cell proliferation, increased Foxp3+ regulatory T cell numbers, and increased indoleamine 2,3-dioxygenase activity. These results indicate that MSC infusion and costimulation blockade have complementary immune-modulating effects that can be used for a broad number of applications in transplantation, autoimmunity, and regenerative medicine.
Observation of inactivation of Bacillus sbtilis spores under exposures of oxygen added argon atmospheric pressure plasma jet
Authors: Shen Jie , Cheng Cheng , Zhao Ying , Xiao Dezhi , Lan Yan , Xie Hongbing , Cheng Junli , Meng Yuedong , Li Jiangang , Chu Paul K 
Published: October 2014

Abstract
The inactivation of Bacillus subtilis spores by an Ar plasma jet mixed with different amounts of oxygen is reported. 5.8 × 106
B. subtilis spores are sterilized by an Ar/O2 (8.7%) plasma jet after exposure for 2 min. The densities of ozone and oxygen radicals in the Ar/O2 plasma jet increase with oxygen concentration and are estimated by optical spectroscopy diagnostic. The malondialdehyde (MDA) test shows that oxygen radicals participate in bacterial inactivation. Scanning electron microscopy (SEM) reveals the deformation of the spore shape due to etching by oxygen radicals and the dependence of the degree of deformation on the density of oxygen radicals.
Daily Sedation Interruption vs Continuous Sedation in Pediatric Patients Receiving Mechanical Ventilation
Authors: Shu Wen Toh Theresa , R. R. Pravin , Ho Karen Hwee Ying , Sultana Rehena , Couban Rachel , Choong Karen , Lee Jan Hau 
Published: August 2024

ImportanceThe effectiveness of daily sedation interruption (DSI, defined as temporary interruption of sedation) has yet to be demonstrated in critically ill pediatric patients.ObjectiveTo compare the clinical outcomes of DSI vs continuous intravenous (IV) sedation in patients receiving invasive mechanical ventilation (MV) support in the pediatric intensive care unit (PICU).Data SourcesA systematic search for studies was conducted using predefined keywords and Medical Subject Headings in 5 major databases (PubMed, Embase, Web of Science, CINAHL [Cumulated Index to Nursing and Allied Health Literature], and Cochrane Central Register of Controlled Trials) from database inception to October 31, 2023.Study SelectionRetrospective and prospective observational studies, randomized clinical trials (RCTs), and systematic reviews were assessed for inclusion. Studies were eligible if they compared DSI to continuous IV sedation in patients aged 18 years or younger requiring MV in the PICU.Data Extraction and SynthesisStudy characteristics, including the types of sedation, sedation protocols, and clinical outcomes, were extracted. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) reporting guideline was followed. A random-effects model was used to pool results from articles for the meta-analysis.Main Outcomes and MeasuresThe primary outcomes of interest were duration of MV and length of PICU stay. Secondary outcomes included total sedative dose requirement, adverse events (eg, complications associated with MV, withdrawal, and delirium), and mortality.ResultsA total of 6 RCTs with 2810 pediatric patients (1569 males [55.8%]; mean age, 26.5 [95% CI, 15.0-37.9] months) were included in the final analysis; patients had a mean PRISM (Pediatric Risk of Mortality) score of 13.68 (95% CI, 10.75-16.61). Compared with continuous IV sedation, DSI was associated with a reduction in length of PICU stay (5 studies, n = 2770; mean difference [MD], −1.45 [95% CI, −2.75 to −0.15] days; P = .03]. There was no difference in MV duration (5 studies, n = 2750; MD, −0.93 [95% CI, −1.89 to 0.04] days; P = .06), total doses of midazolam (3 studies, n = 191; MD, −1.66 [95% CI, −3.95 to 0.63] mg/kg) and morphine used (2 studies, n = 189; MD, −2.63 [95% CI, −7.01 to 1.75] mg/kg), or adverse events (risk ratio [RR], 1.03 [95% CI, 0.74-1.42]; P = .88). There was no difference in mortality between patients exposed vs not exposed to DSI (RR, 0.89 [95% CI, 0.55-1.46]; P = .65).Conclusions and RelevanceThis systematic review and meta-analysis found that use of DSI in pediatric patients was associated with reduced length of PICU stay with no increase in adverse events. Further research is needed to ascertain whether this strategy is associated with improved neurodevelopmental outcomes in PICU survivors.
Lignan Intake and Type 2 Diabetes Incidence Among US Men and Women
Authors: Wang Siyue , Hu Yang , Liu Binkai , Li Yanping , Wang Molin , Sun Qi 
Published: August 2024

ImportanceLignans are phytoestrogens abundant in Western diets and may be associated with type 2 diabetes (T2D) risk.ObjectiveTo prospectively investigate associations between lignan intake and T2D incidence.Design, Setting, and ParticipantsPopulation-based cohort study of US men and women enrolled in the Nurses’ Health Study (NHS, 1984-2018), NHSII (1991-2019), and Health Professionals Follow-Up Study (HPFS, 1986-2020), as well as 496 participants from the Men’s Lifestyle Validation Study (MLVS). Participants were free of T2D, cardiovascular disease, and cancer at baseline. Data were analyzed from November 2022 to July 2023.ExposuresTotal and individual lignans were assessed using a validated food frequency questionnaire, which was updated every 2 to 4 years. In the MLVS, lignan intake was measured using 2 sets of 7-day diet records (7DDRs).Main Outcomes and MeasuresIncident T2D cases were confirmed using American Diabetes Association diagnostic criteria. Cox proportional hazards models were used to assess multivariable-adjusted associations.ResultsThe current study included 201 111 participants (mean [SD] age, 44.7 [10.1] years; 161 169 female participants [80.2%]; 2614 African American participants [1.3%], 1609 Asian participants [0.8%], 2414 Hispanic and other race or ethnicity participants [1.2%], and 194 474 White participants [96.7%]) from the HPFS, NHS, and NHSII studies. The median (IQR) total lignan intake of the highest quintile ranged from 355.1 (330.2-396.9) μg/d in NHS to 459.9 (422.2-519.5) μg/d in HPFS at the median follow-up time. Over 5 068 689 person-years, 20 291 incident cases of T2D were identified. Higher lignan intake was inversely associated with T2D incidence, except for lariciresinol. The multivariable-adjusted pooled hazard ratios (HRs) for the highest vs lowest quintiles were 0.87 (95% CI, 0.83-0.91) for total lignans, 0.72 (95% CI, 0.69-0.76) for secoisolariciresinol, 0.92 (95% CI, 0.87-0.96) for pinoresinol, 0.93 (95% CI, 0.89-0.98) for matairesinol, and 0.99 (95% CI, 0.94-1.04) for lariciresinol. Secoisolariciresinol intake exhibited a significant inverse association with T2D risk among individuals with obesity (HR, 0.75 for body mass index [BMI] ≥30; 95% CI, 0.71-0.79 vs HR, 0.82 for BMI &amp;lt;25; 95% CI, 0.81-0.83; P &amp;lt; .001 for interaction) and premenopausal women (HR, 0.67 for premenopausal women; 95% CI, 0.65-0.69 vs HR, 0.82 for the past use of hormones; 95% CI, 0.76-0.88; P = .003 for interaction). Dietary lignan assessed with 7DDRs was associated with lower HbA1c levels (percentage change range from −0.92% to 1.50%), as well as lower C-reactive protein levels and better lipid profiles.Conclusions and RelevanceThis cohort study found that long-term lignan consumption was associated with a lower T2D risk, particularly among individuals with obesity and premenopausal women.
Precision Cancer Medicine 2.0—Oncology in the postgenomic era
Authors: Masina Riccardo , Caldas Carlos 
Published: August 2024

Genomic medicine has transformed the lives of patients with cancer by enabling individualised and evidence‐based clinical decision‐making. Despite this progress, the implementation of precision cancer medicine is limited by its dependence on isolated biomarkers. The development of bulk and single‐cell multiomic technologies has revealed the enormous complexity of the cancer ecosystem. Beyond the cancer cell, the tumour microenvironment, macroenvironment and host factors, including the microbiome, profoundly influence the cancer phenotype, and accounting for these enhances the resolution of precision medicine. The advent of robust multiomic profiling and interpretable machine learning algorithms mark the dawn of a new postgenomic era of personalised cancer medicine. In Precision Cancer Medicine 2.0, high‐resolution personalised clinical decision‐making is informed by the comprehensive multiomic profiling of tumour and host, integrated using artificial intelligence.
Sensitive Colorimetric Lateral Flow Assays Enabled by Platinum‐Group Metal Nanoparticles with Peroxidase‐Like Activities
Authors: Shao Shikuan , Wang Xiaochuan , Sorial Caroline , Sun Xiaohan , Xia Xiaohu 
Published: August 2024

AbstractThe last several decades have witnessed the success and popularity of colorimetric lateral flow assay (CLFA) in point‐of‐care testing. Driven by increasing demand, great efforts have been directed toward enhancing the detection sensitivity of CLFA. Recently, platinum‐group metal nanoparticles (PGM NPs) with peroxidase‐like activities have emerged as a type of promising colorimetric labels for enhancing the sensitivity of CLFA. By incorporating a simple and rapid post‐treatment process, the PGM NP‐based CLFAs are orders of magnitude more sensitive than conventional gold nanoparticle‐based CLFAs. In this perspective, the study begins with introducing the design, synthesis, and characterization of PGM NPs with peroxidase‐like activities. The current techniques for surface modification of PGM NPs are then discussed, followed by operation and optimization of PGM NP‐based CLFAs. Afterward, opinions are provided on the social impact of PGM NP‐based CLFAs. Lastly, this perspective is concluded with an outlook of future research directions in this emerging field, where the challenges and opportunities are discussed.