bluuebunny/crossref_metadata_2025_split huggingface dataset:
Erythema Multiforme in a 25‐Day Old Neonate
Authors: Ang‐Tiu Charlene U. , Nicolas Marie Eleanore O. 
Published: September 2012

AbstractErythema multiforme is an acute, self‐limiting, mucocutaneous hypersensitivity reaction characterized by distinctive target lesions. Most cases have been attributed to infection. Erythema multiforme occurs mainly in young adults and is extremely rare during the neonatal period. We report a 25‐day‐old girl who presented with target skin lesions on both the palms and soles with no other associated symptoms. She had no remarkable maternal, birth, or past medical history. Complete blood count, urinalysis, chest radiography, and herpes simplex virus 1 and 2 immunoglobulin G (IgG) titers revealed no abnormalities. Pathologic examination showed vacuolar interface change and dyskeratotic cells in the epidermis consistent with erythema multiforme. This unusual case emphasizes the importance of recognizing diagnostic clues in examining patients. Even in the presence of uncharacteristic factors, the typical target lesions of erythema multiforme are distinctive.
Rapid loading of intravenous lacosamide: Efficacy and practicability during presurgical video‐EEG monitoring
Authors: Li Wenjie , Stefan Hermann , Matzen Julia , Rampp Stefan , Heinze Hans‐Joachim , Schmitt Friedhelm C. 
Published: September 2012

SummaryPurpose: This study investigates immediate efficacy and safety of intravenous application of de novo lacosamide (LCM) as add‐on therapy in patients with pharmacoresistant focal epilepsy.Methods: During presurgical video–electroencephalography (EEG) monitoring, 17 adult inpatients received LCM infusion (200 mg every 12 h for 2–3 days) followed by oral formulation with the same regimen. Before and after intravenous application of LCM, seizures and interictal epileptiform discharges (IEDs) recorded with continuous video‐EEG monitoring were analyzed, and an assessment of adverse events (AEs) was performed daily. To evaluate the midterm tolerability and efficacy, follow‐up visits were conducted 1 and 3 months after discharge from hospital.Key Findings: In the acute phase, intravenous initiation of LCM was well tolerated with few mild or moderate AEs (3 of 17, 17.6%). A significant reduction of seizure frequency in the treatment phase as compared to mean seizure frequency in the 2‐day baseline phase was achieved (p < 0.05 for the first treatment day, and p < 0.005 for the second treatment day). On the first treatment day, 61.5% of the patients were seizure free, and 84.6% on the second treatment day. IED reduction after intravenous application of LCM was not significant. After 1 month, the 50% responder rate was 46.6% and after the 3‐month period, 42.8%.Significance: Our data suggest that rapid intravenous initiation of de novo LCM is safe and may protect against seizures in a rapid and midterm time window.
Epilepsy in Rett syndrome, and CDKL5‐ and FOXG1‐gene–related encephalopathies
Authors: Guerrini Renzo , Parrini Elena 
Published: September 2012

SummaryRett syndrome is an X‐linked neurodevelopmental disorder that manifests in early childhood with developmental stagnation, and loss of spoken language and hand use, with the development of distinctive hand stereotypies, severe cognitive impairment, and autistic features. About 60% of patients have epilepsy. Seizure onset before the age of 3 years is unlikely, and onset after age 20 is rare. Diagnosis of Rett syndrome is based on key clinical elements that identify “typical” Rett syndrome but also “variant” or “atypical” forms. Diagnostic criteria have been modified only slightly over time, even after discovering that MECP2 gene alterations are present in >90% of patients with typical Rett syndrome but only in 50–70% of atypical cases. Over the last several years, intragenic or genomic alterations of the CDKL5 and FOXG1 genes have been associated with severe cognitive impairment, early onset epilepsy and, often, dyskinetic movement disorders, which have variably been defined as Rett variants. It is now clearly emerging that epilepsy has distinctive characteristics in typical Rett syndrome and in the different syndromes caused by CDKL5 and FOXG1 gene alterations. The progressive parting of CDKL5‐ and FOXG1‐gene–related encephalopathies from the core Rett syndrome is reflected by the effort to produce clearer diagnostic criteria for typical and atypical Rett syndrome. Efforts to characterize the molecular pathology underlying these developmental encephalopathies are pointing to abnormalities of telencephalic development, neuronal morphogenesis, maturation and maintenance, and dendritic arborization.
A guinea pig model of mesial temporal lobe epilepsy following nonconvulsive status epilepticus induced by unilateral intrahippocampal injection of kainic acid
Authors: Carriero Giovanni , Arcieri Salvatore , Cattalini Alessandro , Corsi Laura , Gnatkovsky Vadym , de Curtis Marco 
Published: September 2012

SummaryPurpose:  Models of temporal lobe epilepsy are commonly utilized to study focal epileptogenesis and ictogenesis. The criteria that define animal models representative of human mesial temporal lobe may vary in different laboratories. We describe herein a focal epilepsy model of mesial temporal (hippocampal) origin that relies on the analysis of interictal and ictal electroencephalography (EEG) patterns and on their correlation with seizure symptoms and neuropathologic findings. The study is based on guinea pigs, a species seldom utilized to develop chronic epilepsy models.Methods:  Young adult guinea pigs were bilaterally implanted under isoflurane anesthesia with epidural electrodes over somatosensory cortex and depth electrodes in CA1 hippocampal region. A stainless steel guide cannula was positioned unilaterally in the right dorsal hippocampus to inject 1 μl of 0.9% NaCl solution containing 1 μg kainic acid (KA). One week after surgery, continuous 24 h/day video‐EEG monitoring was performed 48 h before and every other week after KA injection, for no <1 month. EEG data were recorded wide‐band at 2 kHz. After video‐EEG monitoring, brains were analyzed for thionine and Timm staining and glial fibrillary acid protein (GFAP) immunostaining.Key Findings:  Unilateral injection of KA in dorsal hippocampus of guinea pigs induces an acute nonconvulsive status epilepticus (SE) that terminates within 24 h (n = 22). Chronic seizures with very mild motor signs (undetectable without EEG monitoring) and highly variable recurrence patterns appear in 45.5% (10 of 22) KA‐treated animals, with variable delays from the initial SE. In these animals interictal events, CA1 cell loss, gliosis, and altered Timm staining pattern were observed. The induction of a chronic condition did not correlate with the duration of the nonconvulsive acute SE, but correlated with the extension and quality of neuropathologic damage.Significance:  We demonstrate that a model of hippocampal (mesial temporal lobe) epilepsy can be developed in the guinea pig by intrahippocampal injection of KA. Seizure events in this model show little behavioral signs and may be overlooked without extensive video‐EEG monitoring. The establishment of a chronic epileptic condition correlates with the extension of the hippocampal damage (mainly cell loss and gliosis) and not with the intensity of the initial SE.
Fuel Economy and Greenhouse Gas Emissions Labeling for Plug‐In Hybrid Vehicles from a Life Cycle Perspective
Authors: MacPherson Nathan D. , Keoleian Gregory A. , Kelly Jarod C. 
Published: September 2012

SummaryFuel economy has been an effective indicator of vehicle greenhouse gas (GHG) emissions for conventional gasoline‐powered vehicles due to the strong relationship between fuel economy and vehicle life cycle emissions. However, fuel economy is not as accurate an indicator of vehicle GHG emissions for plug‐in hybrid (PHEVs) and pure battery electric vehicles (EVs). Current vehicle labeling efforts by the U.S. Environmental Protection Agency (EPA) and Department of Transportation have been focused on providing energy and environmental information to consumers based on U.S. national average data. This article explores the effects of variations in regional grids and regional daily vehicle miles traveled (VMT) on the total vehicle life cycle energy and GHG emissions of electrified vehicles and compare these results with information reported on the label and on the EPA's fuel economy Web site. The model results suggest that only 25% of the life cycle emissions from a representative PHEV are reflected on current vehicle labeling. The results show great variation in total vehicle life cycle emissions due to regional grid differences, including an approximately 100 gram per mile life cycle GHG emissions difference between the lowest and highest electric grid regions and up to a 100% difference between the state‐specific emission values within the same electric grid regions. Unexpectedly, for two regional grids the life cycle GHG emissions were higher in electric mode than in gasoline mode. We recommend that labels include stronger language on their deficiencies and provide ranges for GHG emissions from vehicle charging in regional electricity grids to better inform consumers.
The 30 minute rule for red blood cells: in vitro quality assessment after repeated exposure to 30°C
Authors: Thomas Stephen , Hancock Vicky , Cardigan Rebecca 
Published: September 2012

BACKGROUND: Red blood cells (RBC) may be out of temperature control only for 30 minutes before they must be discarded, but evidence for this rule is weak. We investigated the effect on RBC quality of multiple exposures to 30°C.STUDY DESIGN AND METHODS: RBC units made after 24 hours of whole blood ambient hold were pooled and split into adult and pediatric units and exposed to permitted deviations (5‐hr core temperature 10°C, 12‐hr surface temperature 10°C). Test units were exposed to 30°C once, twice, or three times on each of Days 15, 17, and 21, for 30 or 60 minutes. Negative controls were not exposed to 30°C; positive control was exposed to 30°C for 24 hours.RESULTS: Adult units exposed once for 30 or 60 minutes (×3 occasions) showed no more hemolysis than negative control. Units exposed to 30°C for two or three periods of 60 minutes showed more hemolysis from Day 28. Hemolysis in pediatric units exposed for 30 minutes (×3) was not increased but units exposed to one or two periods of 60 minutes (×3) showed higher hemolysis. No differences were seen in supernatant potassium. ATP remained at an acceptable level on Day 28 in all but positive controls.CONCLUSIONS: There was no evidence of significant damage to RBC after exposure to 30°C for three periods of 30 minutes. Multiple exposures of 60 minutes caused limited damage but this was within current regulatory limits if there were three or fewer exposures, suggesting that a 60‐minute rule may be feasible.
Group Buying, Buyer Heterogeneity, and Sellers' Bargaining Power*
Authors: Li Xinxin 
Published: September 2012

ABSTRACTGroup buying enables collective bargaining opportunity that individual buyers lack to negotiate prices with sellers. This potential negotiation capability has two opposing effects. On the one hand, the prospect of the group being able to negotiate price with its rival forces each seller to lower its price offer, as too high a price will induce the group to give its rival an opportunity to undercut its price via negotiation, likely taking away all the buyers. On the other hand, the potential negotiation opportunity may also discourage sellers from competing aggressively in their price offers, as the benefit of charging a low price could be offset by competitors in negotiation, thus yielding overall higher prices for the buyers. In this study, we find that compared to individual purchase, buyers benefit from collective bargaining opportunity by group buying only if sellers’ bargaining power relative to the buyer group is low and/or buyers’ preferences toward the sellers are sufficiently differentiated. Given buyers’ strategic choice of group purchase, sellers may be worse off with a further increase in bargaining power, and so may social welfare.
Supply Chains in Sub‐Saharan Africa: A Decision Support System for Small‐Scale Seed Entrepreneurs*
Authors: Martens Bobby J. , Scheibe Kevin P. , Bergey Paul K. 
Published: September 2012

ABSTRACTIt is necessary to infuse a consistent supply of improved seed varieties into local sub‐Saharan African crop production to improve low crop yields. The best distribution channel for the improved seed varieties may be small‐scale commercial seed companies, but local entrepreneurs struggle to determine whether such businesses are viable. Using a multi‐echelon supply chain approach, a decision support system (DSS) was designed to help African seed entrepreneurs make informed decisions about small‐scale seed chain businesses. Specifically, entrepreneurs make decisions about where to locate seed enterprises, with which farmers to contract, and where to store seed. Optimization and simulation modeling are used to evaluate infrastructure variables such as distance, transportation cost, and storage loss and cost in three development level areas. Currently, the decision tool is used in Mozambique, Malawi, Kenya, and Tanzania. The model has supported the start‐up of at least 17 small seed companies that are now introducing improved seed varieties into villages and farms. The DSS applies decision science research in a humanitarian application and offers important managerial implications about supply chain infrastructure to nongovernmental organizations and humanitarian groups. Such applications are vital as groups such as USAID, the Gates Foundation, and the International Crops Research Institute for the Semi‐Arid Tropics (ICRISAT) continue to move toward micro‐enterprise, value chain, and market‐oriented development programs.
On‐Call Overtime for Service Workforce Scheduling when Demand Is Uncertain
Authors: Campbell Gerard M. 
Published: September 2012

ABSTRACTThis article builds on prior research to develop shift scheduling models that include on‐call overtime for service environments where demand is uncertain. The research is motivated by recent developments in nurse scheduling, such as laws prohibiting mandatory overtime and the popularity of self‐scheduling systems. For single‐period scenarios, models are developed, solution methods are described, and results are explored for a variety of environments. Results show that the use of on‐call overtime can reduce costs slightly, with the amount of savings dependent on characteristics of the scheduling environment. The factor that most significantly affects cost savings is the cost of outside agency workers relative to overtime workers. In addition to lowering costs, on‐call overtime greatly reduces reliance on outside agency workers, which can have important practical implications in terms of quality of service and workforce morale. Results based on single‐period models motivate multiperiod formulations for single‐ and multidepartment scenarios, and solution methods are outlined for those cases. The possibility of using multiperiod models within a rolling horizon framework with forecast updating is discussed. This goes along with an extension of the traditional workforce management hierarchy that separates overtime and regular‐time scheduling, as seen in practice with self‐scheduling and shift‐bidding systems.
The Impact of Contract Manufacturing on Inventory Performance: An Examination of U.S. Manufacturing Industries
Authors: Cheng Liang‐Chieh (Victor) , Cantor David E. , Dresner Martin , Grimm Curtis M. 
Published: September 2012

ABSTRACTIn recent years, a growing number of original equipment manufacturers (OEMs) have transferred their manufacturing processes to specialized firms, known as contract manufacturers. In so doing, contract manufacturers can reduce an OEM's production costs and provide OEMs with flexibility in the production process. We examine another potential reason for the use of contract manufacturing—the potential for efficiency gains from inventory reductions. Employing econometric models and data representing manufacturing industries in the USA, we provide statistical evidence that contract manufacturing can lead to lower industry‐wide inventory levels, after controlling for other relevant factors. Key managerial implications are derived from the analysis.
Supply Chain Management of Fresh Products with Producer Transportation*
Authors: Xiao Yongbo , Chen Jian 
Published: September 2012

ABSTRACTThis article considers a class of fresh‐product supply chains in which products need to be transported by the upstream producer from a production base to a distant retail market. Due to high perishablility a portion of the products being shipped may decay during transportation, and therefore, become unsaleable. We consider a supply chain consisting of a single producer and a single distributor, and investigate two commonly adopted business models: (i) In the “pull” model, the distributor places an order, then the producer determines the shipping quantity, taking into account potential product decay during transportation, and transports the products to the destination market of the distributor; (ii) In the “push” model, the producer ships a batch of products to a distant wholesale market, and then the distributor purchases and resells to end customers. By considering a price‐sensitive end‐customer demand, we investigate the optimal decisions for supply chain members, including order quantity, shipping quantity, and retail price. Our research shows that both the producer and distributor (and thus the supply chain) will perform better if the pull model is adopted. To improve the supply chain performance, we propose a fixed inventory‐plus factor (FIPF) strategy, in which the producer announces a pre‐determined inventory‐plus factor and the distributor compensates the producer for any surplus inventory that would otherwise be wasted. We show that this strategy is a Pareto improvement over the pull and push models for both parties. Finally, numerical experiments are conducted, which reveal some interesting managerial insights on the comparison between different business models.
Pricing for Multiline Insurer: Frictional Costs, Insolvency, and Asset Allocation
Authors: Zhang Li , Nielson Norma 
Published: September 2012

AbstractThis article examines multiline insurance pricing based on the contingent claim approach in a limited liability and frictional costs environment. Capital allocation is based on the value of the default option, which satisfies the realistic assumption that each distinct line undertakes a pro rata share of deficit caused by insurer insolvency. Premium levels, available assets, and default risk interact with each other and reach equilibrium at the fair premium. The assets available to pay for liabilities are not predetermined or given; instead, the premium income and investment income jointly influence the available assets. The results show that equity allocation does not influence the overall fair premium. For a given expected loss, the premium‐to‐expected‐loss ratio for firms offering multiple lines is higher than that for firms only offering a single line, due to the reduced risk achieved through diversification. Premium‐to‐expected‐loss ratio and equity‐to‐expected‐loss ratio vary across lines. Lines having a higher possibility or claim amount not being paid in full exhibit lower premium‐to‐expected‐loss ratio and higher equity‐to‐expected‐loss ratio. Positive correlation among lines of business results in lower premium‐to‐expected‐loss ratio than when independent losses are assumed. Positive correlation between investment return and losses reduces the insolvency risk and leads to a higher premium‐to‐expected‐loss ratio.
Out‐of‐Pocket Health Expenditures: A Suggested Role for Social Security
Authors: Zilcha Itzhak , Schneier Nancy 
Published: September 2012

AbstractWe present economic data to demonstrate that the (random) out‐of‐pocket health‐related expenses of seniors who face medical problems are significant and increasing over time. This remains the case even when we take into account the availability of supplemental health insurance. We propose to apply a modest part of Social Security benefits, without increasing the total expenses of this system, to provide mandatory supplemental health insurance for all recipients. Using a theoretical framework we demonstrate that introducing such additional role for Social Security makes individuals (ex ante) better off and hence results in a Pareto dominating new regime for Social Security.
The Impacts of Surrender Options on Reserve Durations
Authors: Tsai Chenghsien 
Published: September 2012

AbstractEstimating the interest rate risk of life insurance reserves is essential for insurers, and surrender options are critical to the estimation. This article advances our understanding of how surrender options affect the durations of reserves. We identify a pattern of the reserve duration with respect to the interest rate that is important in explaining how surrender rate levels and the interest‐rate sensitivity of surrenders affect reserve durations. We further found that the surrender behavior that is more positively related to the interest rate produces larger/smaller effective dollar durations when the interest rate is low/high.
The influence of population oral health on the dental team
Authors: Robinson Peter G. , Dyer Thomas A. , Teusner Dana 
Published: September 2012

AbstractThis presentation focuses on the use of dental therapists as substitutes for dentists in the provision of some aspects of dental care. Our premise is that the use of therapists is a ‘good thing’ if it delivers a higher quality service. The care that may be provided by therapists is appropriate to population needs. They have been used to increase access to care in a number of countries by supplementing the volume and reach of services, which enhances equity. Therapists are socially acceptable where they are integrated into existing dental systems, but concerted work may be necessary to increase their acceptability if their use is to be introduced or expanded elsewhere. There is no reason to suspect that therapists offer less effective care than dentists, and available data are compatible with this view. More data may be required to lend political support for their greater use. The efficiency of teams is sensitive to the way in which they are organized and funded. Substitution of dentists by therapists within small dental teams creates complexities and costs that reduce efficiency. Conversely, where therapists can work with relative independence, diagnosing and treating patients without direct supervision, then efficiency may be high. Despite opportunities for improving the quality of care, the main barrier for increasing their use is the dental profession. Dental organizations tend to act as guilds, preventing or restricting the deployment of therapists. Dental public health practitioners therefore have a role as advocates for their greater use. At present, the use of therapists does not appear to be influenced by the health of the population.