bluuebunny/crossref_metadata_2025_split huggingface dataset:
NOSOCOMIAL RESPIRATORY SYNCYTIAL VIRUS BRONCHIOLITIS IN PRETERM INFANTS: CHARACTERISTICS OF THE COURSE, TREATMENT АND PREVENTION IN CLINICAL PRACTICE
Authors: Ovsyannikov D. Yu. , Degtyarev D. N. , Ryumina I. I. , Krsheminskaya I. V. , Orlovskaya I. V. 
Published: August 2015

Objective: to study the clinical, laboratory and radiological features of the course of nosocomial bronchiolitis respiratory syncytial viral (RSV ) etiology and effectiveness of the therapy in preterm infants in the neonatal hospital conditions. Patients and Methods: We analyzed case histories of 10 hospitalized patients who had RSV etiology bronchiolitis established by RIF / PCR in neonatal Moscow hospitals in 2011-2013. Results: RSV infection in hospitalized preterm infants with and without bronchopulmonary dysplasia runs hardly, requiring treatment in the intensive care unit, oxygen therapy and lungs mechanical ventilation. The respiratory failure is the symptom of the of RSV bronchiolitis severity. X-ray picture of the disease is characterized by peribronchial changes, emphysematous swelling , segmental infiltration and bronchial obstruction (atelectasis, hypoventilation ). The frequency of bacterial complications of RSV bronchiolitis is low. In clinical practice newborns with severe RSV bronchiolitis are treated with antibiotics, bronchodilators, steroids. The timely isolation of patients can prevent the extention of the infection in the hospital. Conclusions: The preventive measures are needed to prevent the extention of RSV in neonatal hospitals, including specific immune prophylaxisof RSV infection in children at risk .
EFFICIENCY AND SAFETY OF HUMAN MONOCLONAL ANTIBODIES TO TNF-Α IN CHILDREN WITH JUVENILE IDIOPATHIC ARTHRITIS IN PRIMARY AND SECONDARY INEFFECTIVENESS OF OTHER BIOLOGICALS
Authors: Alexeeva E. I. , Baranov A. A. , Mitenko E. V. , Bzarova T. M. , Valieva S. I. , Denisova R. V. , Isaeva K. B. , Chistyakova E. G. , Sleptsova T. V. , Taibulatov N. I. , Zelikovich E. I. , Kurilenkov G. V. 
Published: August 2015

Purpose: To evaluate the safety and efficiency of adalimumab in children with severe refractory JIA with primary inefficiency, partial effect or loss of the effectiveness of other biologicals. Patients and methods: The article presents the results of the retrospective observational study of the efficacy and safety of adalimumab in 68 patients aged 10 (3, 17) years with various embodiments of JIA , with the primary inefficiency or partial or loss of the effectiveness of other biologicals. JIA diagnosis established on the basis of criteria ILAR (International League of Associations for Rheumatology). Results: Efficacy was assessed during 1 year in 68 and 2 years - in 56 patients . At the 24th week we observed the improvement by criteria AKR in 100 , 91 and 74 % of patients , respectively, and at the 52 th week - in 100 , 96 and 90 % , respectively. Inactive disease status was recorded in 55.8, 66,1 and 98.2 % of study participants after 6 months, 1 and 2 years, respectively. Remission was achieved in 55.8 and 96.4 % of patients after 1 and 2 years of observation, respectively. Conclusions: Adalimumab was effective and well tolerated by patients with primary inefficiency, partial and loss of efficiency of other biologicals. In clinical practice, patients with non-systemic JIA transition to the second TNF-α blocker can restore the biological effect of the first drug without increasing the frequency of infectious AEs.
CURRENT CONCEPTS OF PERINATAL ISCHEMIC INJURY IN THE BRAIN NEUROVASCULAR UNIT: MOLECULAR TARGETS FOR NEUROPROTECTION
Authors: Morgun A. V. , Kuvacheva N. V. , Taranushenko T. E. , Khilazhieva E. D. , Malinovskaya N. A. , Gorina Ya. V. , Pozhilenkova E. A. , Frolova O. V. , Salmina A. B. 
Published: August 2015

Perinatal hypoxic-ischemic brain injury is a relevant medical and social problem. Among many pathological processes in the neonatal period perinatal hypoxic-ischemic injury is a major cause of further hemorrhage, necrotic and atrophic changes in the brain. This review presents recent data on the basic mechanisms of the hypoxic-ischemic brain injury along the concept of neurovascular unit (neurons, astrocytes, endothelial cells, pericytes) with the focus on alterations in cell-to-cell communication. Pathological changes caused by ischemia-hypoxia are considered within two phases of injury (ischemic phase and reperfusion phase). The review highlights changes in each individual component of the neurovascular unit and their interactions. Molecular targets for pharmacological improvement of intercellular communication within neurovascular unit as a therapeutic strategy in perinatal brain injury are discussed.
ONCOGYNECOLOGICAL ASPECTS ОF ADNEXAL MASSES
Authors: Gasparov A. S. , Zhordania K. I. , Payanidi Yu. G. , Dubinskaya E. D. 
Published: August 2015

Adnexal masses are frequently found in both symptomatic and asymptomatic women. The frequency of them is 7,8% in reproductive aged women and 2,5–18% in postmenopausal patients. Aim: to investigate clinical significance of the Risk of Malignancy Index (RMI) and to compare it with histological findings in patients with adnexal masses. Patients and methods: 345 patients with adnexal masses were evaluated. Depending on the menopausal status, serum CA-125 level and ultrasonographic findings RMI scores were calculated for each of patients. Results: according to RMI all the patients were divided in to two groups: first group — 283 (62%) of patients with RMI less then 200 and the second group — 52 (38%) women with RMI more then 200. The patients of the second group were referred to the oncologist. Among the patients with RMI 200, 137 (48,4%) endometriomas, 73 (25,8%) serous cystadenoma, 45 (15,9%) dermoid cysts, 22 (7,8%) paraovarian cysts, 2 (0,7%) adenocarcinoma were detected after histological examination. In patients with RMI 200, 25% of benign ovarian tumors, 34,6% of borderline and 40,4% of malignant tumors were verified. Conclusions: RMI when used in the presence of a pelvic mass is a useful triage tool to determine those women who should be referred to a gynaecological oncologist. During laparoscopy, in cases of intraoperative malignancy suspicion staging should be performed: videorecord of the surgery, biopsy of the adnexal mass and contralateral ovary, biopsy of the omentum and peritoneum, and aspiration of the peritoneal fluid for cytological examination.
AGE AND SEXUAL CHANGES STRUCTURE OF GENES CYTOKINES NETWORKS IN RUSSIAN POPULATION
Authors: Konenkov V. I. , Prokof'ev V. F. , Shevchenko A. V. , Chernyavskii A. M. , Karas'kov A. M. 
Published: August 2015

Objective: to study frequencies of occurrence of the combined genetic attributes including different variants of cytokines genotypes (TNFA, IL1B, IL4, IL6, IL10, VEGF), in different on sexual and age groups in population of Siberia Caucasoid. Material and methods. Frequencies of distribution of variants of structure genes cytokines networks among 500 representatives of Siberia Caucasian population, men and women of two age groups - more younger than 35 years ("young") and 55 and more years ("elderly") are investigated. In structure of investigated genes cytokines net has come 10 variants of polymorphic sites of cytokines genes and vascular endothelial growth factor gene: TNFА-863 C→A, TNFА-308 G→A, TNFА-238 G→A, IL1B-31 С→T, IL4-590 С→T, IL6-174 G→C, IL10-1082 G → A, IL10-592 А→С, VEGF-2578 C→A and VEGF+936 С→T. Genotyping are carried out by restriction fragment length polymorphism method. Processing of results carried out on the basis of the original methodological approach including the complex connected computer analysis of genic circuits of various dimension. Results and conclusions. It is shown, that the significant part of variants genes cytokines networks, which widely distributed among young people is completely absent in the "elderly" age group. Such variants disappearing with age separately for men and women are established. At the program mathematical analysis it is established, that parameters of the odds ratio achieve two-place sizes (OR =27, p =0,0004), that testifies to high specificity of complex genetic attributes. Presence in genome such variants of genes cytokines networks , found out in the childhood or young age, as supposed, is unfavorable personalized prognostic factors of life span of the individual.
METODOLOGIAS E VIVÊNCIAS DO DOCENTE NA PERSPECTIVA DA EDUCAÇÃO SUPERIOR INCLUSIVA
Authors: Oliveira Sabrina Ferreira de , Araújo Natália Martinez de 
Published: August 2015

O objetivo desse estudo foi conhecer a experiência dos docentes de uma instituição pública acerca da educação superior inclusiva. Trata-se de uma pesquisa quantiqualitativa, realizadacom 24 docentes em 2013. Verificou-se que a minoria dos professores teve algum tipo decapacitação para lidar com alunos que possuem necessidades educacionais especiais, mas amaior parte já teve a experiência de lidar com esse discente em sala de aula e apresentametodologias de ensino adequadas à diversidade. Essa experiência prévia mostrou-sefundamental para gerar disponibilidade no docente em pensar as estratégias de ensino eaprendizagem adequadas para qualquer aluno. O estudo aponta a necessidade de incluir nasgrades curriculares das graduações e pós-graduações a discussão acerca das estratégiasmetodológicas para o ensino inclusivo.
Food Insecurity and Cost-Related Medication Underuse Among Nonelderly Adults in a Nationally Representative Sample
Authors: Herman Dena , Afulani Patience , Coleman-Jensen Alisha , Harrison Gail G. 
Published: August 2015

Objectives. We investigated whether nonelderly US adults (aged 18–64 years) in food-insecure households are more likely to report cost-related medication underuse than the food-secure, and whether the relationship between food insecurity and cost-related medication underuse differs by gender, chronic disease, and health insurance status.Methods. We analyzed data from the 2011 and 2012 National Health Interview Survey (n = 67 539). We examined the relationship between food insecurity and cost-related medication underuse with the χ2test and multivariate logistic regression with interaction terms.Results. Bivariate and multivariate analyses showed a dose–response relationship between food insecurity and cost-related medication underuse, with an increasing likelihood of cost-related medication underuse with increasing severity of food insecurity (P < .001). This association was conditional on health insurance status, but not substantially different by gender or chronic disease status. Being female, low-income, having no or partial health insurance, chronic conditions, functional limitations, or severe mental illness were positively associated with cost-related medication underuse.Conclusions. Using food insecurity as a risk factor to assess cost-related medication underuse could help increase identification of individuals who may need assistance purchasing medications and improve health for those in food-insecure households.
Self-Reported Health Among Recently Incarcerated Mothers
Authors: Turney Kristin , Wildeman Christopher 
Published: August 2015

Objectives. We examined self-reported health among formerly incarcerated mothers.Methods. We used data from the Fragile Families and Child Wellbeing Study (n = 4096), a longitudinal survey of mostly unmarried parents in urban areas, to estimate the association between recent incarceration (measured as any incarceration in the past 4 years) and 5 self-reported health conditions (depression, illicit drug use, heavy drinking, fair or poor health, and health limitations), net of covariates including health before incarceration.Results. In adjusted logistic regression models, recently incarcerated mothers, compared with their counterparts, have an increased likelihood of depression (odds ratio [OR] = 1.60; 95% confidence interval [CI] = 1.18, 2.17), heavy drinking (OR = 1.79; 95% CI = 1.19, 2.68), fair or poor health (OR = 1.49; 95% CI = 1.08, 2.06), and health limitations (OR = 1.78; 95% CI = 1.27, 2.50). This association is similar across racial/ethnic subgroups and is larger among mothers who share children with fathers who have not been recently incarcerated.Conclusions. Recently incarcerated mothers struggle with even more health conditions than expected given the disadvantages they experience before incarceration. Furthermore, because incarceration is concentrated among those who are most disadvantaged, incarceration may increase inequalities in population health.
Sexual Minority Health Disparities in Adult Men and Women in the United States: National Health and Nutrition Examination Survey, 2001–2010
Authors: Operario Don , Gamarel Kristi E. , Grin Benjamin M. , Lee Ji Hyun , Kahler Christopher W. , Marshall Brandon D. L. , van den Berg Jacob J. , Zaller Nickolas D. 
Published: August 2015

Objectives. We used nationally representative data to investigate health disparities associated with sexual minority status among adults in the United States.Methods. We analyzed data from 11 114 adults who participated in the 2001 to 2010 waves of the National Health and Nutrition Examination Survey. Using multiple logistic regressions, we examined the prevalence of HIV, sexually transmitted infections, mental health problems, cigarette smoking, and alcohol and illicit drug use in sexual minorities and heterosexual adults.Results. After adjusting for sociodemographic characteristics, sexual minority men had greater odds of mental health problems, testing positive for HIV and herpes simplex virus type 2 and self-reported gonorrhea and chlamydia. Sexual minority women had greater odds of mental health problems, testing positive for hepatitis C, smoking, heavy drinking, and illicit drug use.Conclusions. Numerous health disparities continue to face sexual minority men and women in the United States. Notably, health disparities persisted beyond the role of sociodemographic factors, including access to insurance and primary care, suggesting that further research is warranted to identify the determinants of health inequity for sexual minorities.
Demographic and Psychosocial Factors Associated With Psychological Distress and Resilience Among Transgender Individuals
Authors: Bariola Emily , Lyons Anthony , Leonard William , Pitts Marian , Badcock Paul , Couch Murray 
Published: August 2015

Objectives. We examined the independent demographic and psychosocial factors associated with psychological distress and resilience among transgender men and women. Methods. Our data came from an online survey involving a national Australian sample of 169 transgender men and women in 2011. Survey questions assessed demographics; sources of support; contact with lesbian, gay, bisexual, and transgender peers; and experiences of victimization. We assessed the outcomes with the Kessler Psychological Distress Scale and the Brief Resilience Scale. Results. In all, 46.0% of the sample reported high or very high levels of psychological distress. Multivariable regression analyses identified considerably different independent factors for psychological distress and resilience. Younger age, feeling unable to turn to family for support, and victimization experiences were associated with greater psychological distress, whereas higher income, identifying as heterosexual, and having frequent contact with lesbian, gay, bisexual, and transgender peers were associated with greater resilience. Conclusions. With different factors identified for psychological distress and resilience, these findings may help inform the development of tailored mental health interventions and resilience-building programs for this vulnerable population.
How Stigma Surrounding the Use of HIV Preexposure Prophylaxis Undermines Prevention and Pleasure: A Call to Destigmatize “Truvada Whores”
Authors: Calabrese Sarah K. , Underhill Kristen 
Published: August 2015

Antiretroviral preexposure prophylaxis (PrEP; emtricitabine and tenofovir disoproxil fumarate [Truvada]) prevents HIV without penalizing sexual pleasure, and may even enhance pleasure (e.g., by reducing HIV-related anxiety). However, concern about sexual risk behavior increasing with PrEP use (risk compensation) and corresponding stereotypes of promiscuity may undermine PrEP’s preventive potential. In this commentary, we review literature on sexual behavior change accompanying PrEP use, discuss risk compensation concerns and the “Truvada whore” stereotype as PrEP barriers, question the appropriateness of restricting PrEP access because of risk compensation, and consider sexual pleasure as a benefit of PrEP, an acceptable motive for seeking PrEP, and a core element of health. It is essential for science to trump stereotypes and sex-negative messaging in guiding decision-making affecting PrEP access and uptake.
Estimation of Bulk Melt-Temperature from In-Mold Thermal Sensors for Injection Molding, Part A: Method
Authors: Johnston S. P. , Mendible G. A. , Gao R. X. , Kazmer D. O. 
Published: August 2015

Abstract
To improve part quality and consistency injection molders strive to control the temperature of the molten plastic during cavity filling. In-mold temperature sensors can effectively measure the temperature of the mold surface that contacts the melt; however, they do not provide a measure of the bulk melt temperature. An analysis was developed to use data from in-mold thermocouples to predict the plastic's bulk melt temperature. This analysis integrates the heat flux through the mold steel to calculate the bulk melt temperature. A mold instrumented with an in-mold thermocouple and an IR temperature sensor was used to validate the predictions. The effects of changing barrel temperature, coolant temperature, injection velocity, and cooling time were studied using a 21 run DOE. Validation was performed by comparing bulk temperature data from the IR temperature sensor with temperature predictions derived from the in-mold temperature sensor. Trends in the melt temperature were consistently predicted, however, the magnitudes were low due to residual heat remaining in the part at the end of the molding cycle. The analysis was more sensitive to process changes than raw data from the in-mold temperature sensor, thereby improving process observability.
Lithium Ion Conduction in PVdC-co-AN Based Polymer Blend Electrolytes Doped with Different Lithium Salts
Authors: Subbu C. , Rajendran S. , Kesavan K. , Mathew C. M. 
Published: August 2015

AbstractPolymer electrolytes prepared by the complexation of lithium salts with poly(ethylene oxide) (PEO) and poly(vinylidene chloride-co-acrylonitrile) (PVdC-co-AN) will be of great use as separators in lithium polymer batteries. The amorphous nature of the blend electrolyte shows that the conductivity increases by the addition of lithium salts. The presence of C≡N and C=N in PVdC-co-AN are confirmed from the Fourier transform infrared studies. Among the various lithium salts studied, lithium trifluoro methane sulfonoimide [LiN(CF3SO2)2] based electrolyte exhibits the highest ionic conductivity of the order of 0.265 × 10−5Scm−1at room temperature. The sample having a maximum ionic conductivity PEO(80 wt%)/PVdC-co-AN(20 wt%)/LiN(CF3SO2)2(8 wt%) is supported by the lower optical band gap in UV-Visible analysis and low intensity in luminescence studies. Two and three dimensional topographic images of the above sample reveal the presence of micropores. Thermal stability of the prepared electrolytes is studied by thermo gravimetric/differential thermal analysis. Using differential scanning calorimetric analysis, the minimum glass transition temperature (30°C) is observed for the sample doped with LiN(CF3SO2)2. The cyclic voltammetric studies reveal the strong capacitive behavior of the prepared polymer electrolytes. The electrochemical stability windows for the prepared samples are observed using linear sweep voltammetry.
Development of Antimicrobial Poly(∊-caprolactone)/Poly(lactic acid)/Silver Exchanged Montmorillonite Nanoblend Films with Silver Ion Release Property for Active Packaging Use
Authors: Benhacine F. , Hadj-Hamou A. S. , Habi A. , Grohens Y. 
Published: August 2015

AbstractBiodegradable PCL/PLA/Ag-MMT nanoblends with a strong antibacterial activity and a silver ion release property were successfully prepared by melt blending process for active packaging use. The presence of silver exchanged montmorillonite and its interaction with PCL/PLA matrix was evidenced by ATR/FTIR. The morphology was investigated by both XRD and TEM analyses. It was suggested the formation of mainly exfoliated structures with a random dispersion of spherical silver nanoparticles within their composite matrices. The thermal and mechanical properties of these nanomaterials were thoroughly investigated and compared to those of the unfilled blends. The potential of the silver ion release from the PCL/PLA/Ag-MMT film was estimated after immersion in water for several periods of time. The results showed an increase of the amount of silver ions released with growing immersion time of PCL/PLA/Ag-MMT nanoblends. Due to the presence of silver nanoparticles in their matrices, PCL/PLA/Ag-MMT nanoblends showed a total bacteria growth inhibition.
Specificity of induced defenses, growth, and reproduction in lima bean (Phaseolus lunatus) in response to multispecies herbivory
Authors: Moreira Xoaquín , Abdala‐Roberts Luis , Hernández‐Cumplido Johnattan , Cuny Maximilien A. C. , Glauser Gaetan , Benrey Betty 
Published: August 2015

• Premise of the study: Following herbivore attack, plants can either reduce damage by inducing defenses or mitigate herbivory effects through compensatory growth and reproduction. It is increasingly recognized that such induced defenses in plants are herbivore‐specific, but less is known about the specificity of compensatory responses. Damage by multiple herbivores may also lead to synergistic effects on induction and plant fitness that differ from those caused by a single herbivore species. Although largely unstudied, the order of arrival and damage by different herbivore species might also play an important role in the impacts of herbivory on plants.• Methods: We investigated the specificity of defense induction (phenolics) and effects on growth (number of stems and leaves) and reproduction (number of seeds, seed mass, and germination rate) from feeding by two generalist leaf‐chewing herbivores (Spodoptera eridania and Diabrotica balteata) on Phaseolus lunatus plants and evaluated whether simultaneous attack by both herbivores and their order of arrival influenced such dynamics.• Key results: Herbivory increased levels of leaf phenolics, but such effects were not herbivore‐specific. In contrast, herbivory enhanced seed germination in an herbivore‐specific manner. For all variables measured, the combined effects of both herbivore species did not differ from their individual effects. Finally, the order of herbivore arrival did not influence defense induction, plant growth, or seed number but did influence seed mass and germination.• Conclusions: Overall, this study highlights novel aspects of the specificity of plant responses induced by damage from multiple species of herbivores and uniquely associates such effects with plant lifetime fitness.