bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developmental Communication
Authors: Fisher Carla L. 
Published: July 2014

Developmental communication is a relatively new perspective used to study interaction. Adopted in the 1980s and referred to as “developmental” or “life-span” communication, on a most basic level, such research mirrors its sister disciplines (psychology and sociology) in its focus on change across time. Communication scholars first reflected on this perspective after a 1979 National Communication Association Convention, which included a caucus on communication and aging, led by Carl Carmichael and Robert Hawkins. Over the next decade, notable scholars (e.g., Nikolas Coupland, Howard Giles, John Wiemann, Jon F. Nussbaum, Mark Knapp) further advocated the value of this perspective via a Fulbright International Colloquium and numerous books. These scholars heightened the value of a developmental approach to understanding communication. Jon F. Nussbaum’s groundbreaking book, Life-Span Communication: Normative Processes, was published in the late 1980s. Known as one of the most revolutionary developmental communication scholars, Nussbaum proposed that researchers use a life-span lens to better capture complexities of communication across an individual’s entire life. A developmental lens appreciates the notion that communication is not a singular event or object separate from time. Rather, “Communication is a primary skill to be mastered . . . Communication is best viewed as a flow of events across time rather than a static occurrence . . . Communication events are continuously unfolding and impacted by a wide range of individual characteristics and factors as well as previous experiences . . . As the communication process unfolds within human interaction, changes occur on numerous levels that may be manifested in different ways at various points in the life span . . . An individual’s capacity to communicate must continuously develop for that individual to master his or her environment and to interact effectively throughout the transitions, adaptations, and new challenges that arise over the life span” (Pecchioni, et al. 2005, pp. 10–11, cited under General Readings). A developmental lens illuminates that change is an inherent part of human interaction. Life-span research is known for focusing on “real-world” issues, being applied or translational, and interdisciplinary. Therefore, developmental communication scholars are known for engaging with the community and crossing disciplinary boundaries with fields such as psychology, sociology, gerontology, family studies, health, mass communication, and cultural studies. Today, developmental communication research is growing in abundance. Such scholarship has resulted in the production of significant knowledge about individual, relational, and societal levels of how communication evolves over time.
Headspace‐Gas Chromatographic‐Mass Spectrometric Analysis of South American Commercial Solvents and their Use in the Illicit Conversion of Cocaine Base to Cocaine Hydrochloride
Authors: Mallette Jennifer R. , Casale John F. 
Published: July 2014

AbstractThis study presents data that establish the makeup of solvents utilized in illicit cocaine hydrochloride production, as determined via the identification of the occluded solvents in the crystal matrix of the final product. The occluded solvent ratios can differ dramatically from the ratios of the original processing solvents. Additionally, the presented data suggest the diversion of commercial solvents to illicit cocaine hydrochloride laboratories. Thirty‐five commercial solvents were obtained from five chemical manufacturing companies in South America. Each solvent was qualitatively and quantitatively analyzed using static headspace‐gas chromatography‐mass spectrometry (HS‐GC‐MS). After obtaining the chemical profile for each commercial solvent, solvents and/or solvent mixtures were prepared to be comparable in composition to several of the commercial products. Over 90 individual batches of cocaine hydrochloride were prepared from cocaine base using these solvents or solvent mixtures, which match those most commonly employed in clandestine laboratories. Additionally, a number of unique manufacturing by‐products produced from processing solvents were identified, and their significance is discussed.
The English Rogue: Afterlives and Imitations, 1665‐1741
Authors: Orr Leah 
Published: July 2014

AbstractThe English Rogue (1665) is one of the most reprinted and imitated works of fiction from the late seventeenth century, but it has been largely overlooked in recent studies of early fiction. This article analyses the afterlives of The English Rogue to argue that its success derives from later editors, who adapted it to suit changing tastes in the fiction market. Because of its many imitations, abridgements and adaptations, The English Rogue is a good barometer of trends in fiction in the period many modern scholars have identified as the origins of the modern novel form.
Hazardous birthday drinking among young people: population‐based impacts on emergency department and in‐patient hospital admissions
Authors: Callaghan Russell C. , Sanches Marcos , Gatley Jodi M. , Liu Lon‐Mu , Cunningham James K. 
Published: July 2014

AbstractBackground and AimsThere is growing concern about the possible adverse health impacts of binge drinking during birthday celebrations among adolescents and young adults. We estimate the impacts of birthday alcohol use on adolescent and young adult in‐patient/emergency department (ED) hospital admissions.DesignWe employed Autoregressive Integrated Moving Average (ARIMA) intervention analysis to assess whether the rate of ICD‐10 alcohol‐use‐disorder (AUD) events per 1000 in‐patient/ED admissions increased significantly during birthday weeks.SettingAll in‐patient/ED admissions in Ontario, Canada from 1 April 2002 to 31 March 2007.ParticipantsIndividuals aged 12–30 years.MeasurementsAUD events per 1000 in‐patient/ED admissions by age in weeks.FindingsMultiple increases were found. The largest occurred during the birthday week of 19 years of age, the beginning of the minimum legal drinking age (MLDA) in Ontario: AUD admission rates increased (spiked) by 38.30 per 1000 total admissions [95% confidence interval (CI) = 34.66–41.94] among males (a 114.3% increase over baseline), and by 28.13 (95% CI = 25.56–30.70) among females (a 164.0% increase). Among both genders, the second largest birthday‐week spikes occurred during ages 20–22 years, followed by somewhat lower but still pronounced birthday‐week spikes during ages 23–26 years and 30 years (all these spikes: P < 0.05). Birthday‐week spikes occurred as early as age 16 years for males and 14 years for females (both spikes: P < 0.05).ConclusionsThere appears to be an increase in alcohol‐related adverse events from drinking around the time of one's birthday among young adults in Canada.
Seasonal dynamics of macrohabitat use by small mammals in the Okavango Delta, Botswana: implications for landscape‐level disturbance resilience
Authors: Plavsic Militsa J. 
Published: July 2014

AbstractIn a changing climate, it is imperative to understand potential ecosystem resilience at all taxonomic levels. I compare seasonal small mammal utilization of woodlands (tree islands) and grasslands in the Okavango Delta, Botswana, to elucidate macrohabitat relationships and to test whether the two macrohabitats are similar in their ability to serve as a source of colonizers for the other after disturbance. Capture–mark–recapture data revealed that abundances for Dendromus mesomelas and Gerbilliscus leucogaster were higher in grasslands than tree islands, while Mus indutus abundance appeared higher in the grasslands in the dry season but roughly equal in the rainy season. Mastomys spp. and Steatomys pratensis maintained low levels in the grassland habitat throughout the year and experienced a population peak in the tree island habitat during the rainy season. There were no significant differences in sex ratio, mean mass or breeding condition. Dominance and total biomass were higher in the grasslands with the trend more pronounced in the rainy season. Terrestrial small mammals in the Okavango Delta employ differing strategies in macrohabitat selection and some exploit tree islands when herbaceous cover is present. Metacommunity dynamics exist for some species, and both habitats can serve as a source of colonizers under certain conditions.
Efficacy and Safety of PPC‐5650 on Experimental Rectal Pain in Patients with Irritable Bowel Syndrome
Authors: Nielsen Lecia Møller , Olesen Anne Estrup , Andresen Trine , Simrén Magnus , Törnblom Hans , Drewes Asbjørn Mohr 
Published: July 2014

AbstractPPC‐5650 is a new pharmacological agent that can modulate acid‐sensing ion channel activity, leading to a reduction in the pain signal under up‐regulated conditions. The non‐clinical programme for PPC‐5650 supported a role for this novel agent in the treatment of pain in patients with irritable bowel syndrome (IBS). In patients with IBS, the aims of the study were: (1) to assess the efficacy of a single bolus of PPC‐5650 locally applied in the rectum using multi‐modal stimulations of the recto sigmoid and (2) to assess the safety profile of PPC‐5650. The study was a randomized, double‐blind, placebo‐controlled, cross‐over trial in patients with IBS, excluding females of child‐bearing potential. The study consisted of a training visit, study visit 1 and 2 and a follow‐up visit. Rectosigmoid electrical, thermal and mechanical stimulations were performed, pain perception was rated on a pain intensity scale and referred pain areas were assessed. All adverse events were registered.Twenty‐five patients with IBS were enrolled and completed the study (9 women and 16 men; mean age 50.4 ± 12.7 years). No effects of the study drug were found on any of the rectal stimulations or for referred pain areas (all p > 0.05). No significant or clinically relevant treatment‐related differences were seen for the laboratory safety variables or any other reported adverse event.In conclusion, in patients with IBS on rectal sensitivity to multi‐modal stimulations, PPC‐5650 did not produce efficacy relative to placebo. The overall safety and tolerability of PPC‐5650 was acceptable.
Analgesic tolerance to morphine is regulated by PPARγ
Authors: de Guglielmo Giordano , Kallupi Marsida , Scuppa Giulia , Stopponi Serena , Demopulos Gregory , Gaitanaris George , Ciccocioppo Roberto 
Published: July 2014

Background and PurposeOpioid drugs are potent analgesics. However, their chronic use leads to the rapid development of tolerance to their analgesic effects and subsequent increase of significant side effects, including drug dependence and addiction. Here, we investigated the role of PPARγ in the development of analgesic tolerance to morphine in mice.Experimental ApproachWe monitored analgesia on alternate days using the tail immersion test.Key ResultsDaily administration of morphine (30 mg·kg−1, bid) resulted in the rapid development of tolerance to thermal analgesia. Co‐administration of pioglitazone (10 and 30 mg·kg−1, bid) significantly attenuated the development and expression of tolerance. However, pretreatment with GW‐9662 (5 mg·kg−1, bid), a selective PPARγ antagonist, completely abolished this effect. Injection of GW‐9662 and a lower dose of morphine (15 mg·kg−1, bid) accelerated the development of tolerance to its antinociceptive effect. Subsequently, we found that conditional neuronal PPARγ knockout (KO) mice develop a more rapid and pronounced tolerance to morphine antinociception compared with wild‐type (WT) controls. Moreover, in PPARγ KO mice, pioglitazone was no longer able to prevent the development of morphine tolerance.Conclusions and ImplicationsOverall, our results demonstrate that PPARγ plays a tonic role in the modulation of morphine tolerance, and its pharmacological activation may help to reduce its development. These findings provide new information about the role of neuronal PPARγ and suggest that combining PPARγ agonists with opioid analgesics may reduce the development of tolerance and possibly attenuate the potential for opioid abuse.
In vivo properties of KNT‐127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice
Authors: Nozaki C , Nagase H , Nemoto T , Matifas A , Kieffer B L , Gaveriaux‐Ruff C 
Published: July 2014

Background and PurposeActivation of δ opioid (DOP) receptors regulates pain and emotional responses, and also displays ligand‐biased agonism. KNT‐127 (1,2,3,4,4a,5,12,12a‐octahydro‐2‐methyl‐4aβ,1β‐([1,2]benzenomethano)‐2,6‐diazanaphthacene‐12aβ,17‐diol) is a novel DOP receptor agonist inducing analgesia and antidepressant effects in mice. Here, we have assessed KNT‐127 for (i) analgesia against chronic inflammatory pain; (ii) effects on depression, locomotion and DOP receptor internalization; and (iii) for cross‐tolerance to analgesic and antidepressant effects of acute treatment by other DOP receptor agonists.Experimental ApproachInflammatory pain was induced by complete Freund's adjuvant injection into tail or hindpaw, and thermal and mechanical sensitivities were determined in mice. Locomotor and antidepressant‐like effects were measured using actimetry and forced swim test respectively. In vivo KNT‐127 selectivity and internalization were assessed using DOP receptor knockout mice and knock‐in mice expressing fluorescent‐tagged DOP receptors. KNT‐127 was injected acutely at 0.1–10.0 mg·kg−1 or administered chronically at 5 mg·kg−1 daily over 5 days.Key ResultsAcute treatment with KNT‐127 reversed inflammatory hyperalgesia, produced an antidepressant‐like effect but induced neither hyperlocomotion nor receptor sequestration. Chronic treatment with KNT‐127 induced tolerance and cross‐tolerance to SNC80‐induced analgesia, but no tolerance to SNC80‐evoked hyperlocomotor or antidepressant‐like effects.Conclusions and ImplicationsThe DOP receptor agonist KNT‐127 induced agonist‐specific acute and chronic responses, at both behavioural and cellular levels. It displays activities similar to the other recently reported DOP agonists, AR‐M1000390, ADL5747 and ADL5859, and differs from SNC80. SNC80 differs from the other DOP receptor agonists including KNT‐127, by exhibiting ligand‐biased tolerance at this receptor.
Therapeutic perspectives of epigenetically active nutrients
Authors: Remely M , Lovrecic L , de la Garza A L , Migliore L , Peterlin B , Milagro F I , Martinez A J , Haslberger A G 
Published: July 2014

Many nutrients are known for a wide range of activities in prevention and alleviation of various diseases. Recently, their potential role in regulating human health through effects on epigenetics has become evident, although specific mechanisms are still unclear. Thus, nutriepigenetics/nutriepigenomics has emerged as a new and promising field in current epigenetics research in the past few years. In particular, polyphenols, as part of the central dynamic interaction between the genome and the environment with specificity at physiological concentrations, are well known to affect mechanisms underlying human health. This review summarizes the effects of dietary compounds on epigenetic mechanisms in the regulation of gene expression including expression of enzymes and other molecules responsible for drug absorption, distribution, metabolism and excretion in cancer, metabolic syndrome, neurodegenerative disorders and hormonal dysfunction.Linked ArticlesThis article is part of a themed section on Epigenetics and Therapy. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2015.172.issue‐11
Application of Agriculture‐Developed Demographic Analysis for the Conservation of the Hawaiian Alpine Wekiu Bug
Authors: EIBEN JESSE , RUBINOFF DANIEL 
Published: July 2014

AbstractInsects that should be considered for conservation attention are often overlooked because of a lack of data. The detailed information necessary to assess population growth, decline, and maximum range is particularly difficult to acquire for rare and cryptic species. Many of these difficulties can be overcome with the use of life table analyses and heat energy accumulation models common in agriculture. The wekiu bug (Nysius wekiuicola), endemic to the summit of one volcanic mountain in Hawaii, is a rare insect living in an environmentally sensitive alpine stone desert, where field‐based population assessments would be inefficient or potentially detrimental to natural and cultural resources. We conducted laboratory experiments with the insects by manipulating rearing temperatures of laboratory colonies and made detailed observations of habitat conditions to develop life tables representing population growth parameters and environmental models for wekiu bug phenology and demographic change. Wekiu bugs developed at temperatures only found in its environment on sunny days and required the thermal buffer found on cinder cones for growth and population increase. Wekiu bugs required approximately 3.5 months to complete one generation. The bug developed optimally from 26 to 30 °C, temperatures that are much higher than the air temperature attains in its elevational range. The developmental temperature range of the species confirmed a physiological reason why the wekiu bug is only found on cinder cones. This physiology information can help guide population monitoring and inform habitat restoration and conservation. The wekiu bug was a candidate for listing under the U.S. Endangered Species Act, and the developmental parameters we quantified were used to determine the species would not be listed as endangered or threatened. The use of developmental threshold experiments, life table analyses, and degree day modeling can directly inform otherwise unobservable habitat needs and demographic characteristics of extremely rare insects.Aplicación de Análisis Demográfico de Desarrollo Agrícola para la Conservación del Insecto Weiku Alpino Hawaiano
Donor acute kidney injury and short‐term graft outcome in renal transplantation
Authors: Jacobi Johannes , Rebhan Dirk , Heller Katharina , Velden Joachim , Hilgers Karl F. , Wullich Bernd , Eckardt Kai‐Uwe , Amann Kerstin U. 
Published: July 2014

AbstractBackgroundWith increased waiting times for kidney transplantation, marginal organs from expanded criteria donors (ECD) are increasingly offered for allocation. In addition to ECD status, donors may have suffered from acute kidney injury (AKI) prior to organ procurement.MethodsIn this retrospective cohort study, we studied short‐term allograft function in 517 kidney transplants performed between the years 2008–2014. Recipients of allografts from deceased organ donors were categorized as standard criteria donors (SCD) or ECD with or without AKI defined by RIFLE criteria.ResultsOf 382 deceased donations, 174 (45.5%) were classified as ECD and 63 (16.5%) fulfilled AKI criteria. Donor creatinine on hospital admission was similar, whereas creatinine before organ procurement differed (p < 0.001). Despite these differences, serum creatinine and eGFR at discharge and after one yr showed only minor differences between kidneys with or without AKI. In multivariate linear regression analyses, donor AKI was not a predictor of one‐yr allograft function.ConclusionsGiven the poor prognosis of dialysis patients and the increase in waiting time, kidneys from SCD and ECD donors with AKI should be allocated for transplantation. In case of ECD donors with AKI, recipients should be informed about the possibility of permanent non‐function or early graft loss.
Initial characterization of an unidentified Armillaria isolate from Serbia using LSU‐IGS1 and TEF‐1‐α genes
Authors: Keča N. , Klopfenstein N. B. , Kim M.‐S. , Solheim H. , Woodward S. 
Published: July 2014

SummaryArmillaria species have a global distribution and play variable ecological roles, including causing root disease of diverse forest, ornamental and horticultural trees. Accurate identification of Armillaria species is critical to understand their distribution and ecological roles. This work focused on characterizing an unidentified Armillaria isolate from a Serbian forest using pairing, sequencing of the partial large subunit and intergenic spacer‐1 regions of rDNA (LSU‐IGS1) and the translation elongation factor‐1 alpha gene (tef‐1α) genes, and phylogenetic analyses. Despite previously obtained LSU‐IGS1 RFLP patterns that matched the newly described North American Armillaria altimontana, pairing tests and phylogenetic analyses of LSU‐IGS1 and tef‐1α sequences clearly demonstrate that the unidentified isolate is not A. altimontana. Based on LSU‐IGS1, Armillaria gallica isolates were polyphyletic, and the Serbian isolate clustered with a subset of European A. gallica isolates within a well‐supported clade (99%). Based on tef‐1α, the Serbian isolate appeared as a separate, well‐supported clade (97%) that was basal to other poorly resolved, polyphyletic clades containing European A. gallica isolates. It is speculated that the unidentified Armillaria isolate from Serbia could represent an evolutionary ancestral state because of its separate, basal position compared with other clades comprising polyphyletic European A. gallica isolates. Alternatively, this unidentified Serbian isolate could represent an unusual hybrid because of its high‐level sequence heterogeneity, represented by multiple two‐nucleotide codes, within tef‐1α. Further characterization is needed to confirm the taxonomic status and ecological/evolutionary significance of this unique, unknown Armillaria isolate from Serbia.
A micro RNA‐146a polymorphism is associated with coronary restenosis
Authors: Hamann L. , Glaeser C. , Schulz S. , Gross M. , Franke A. , Nöthlings U. , Schumann R. R. 
Published: July 2014

SummaryThe association of the miRNA‐146a polymorphism rs2910164 with atherosclerosis and restenosis was investigated. We found no association with atherosclerosis; however, we found a negative association for the G/C (P = 0.007) and a positive association for the C/C genotype with the risk of restenosis, which is the main drawback for cardiac surgery.
First report on the antibody verification of MICA epitopes recorded in the HLA epitope registry
Authors: Duquesnoy R. J. , Mostecki J. , Marrari M. , da Silva A. S. , da Mata Sousa L. C. D. , do Monte S. J. H. 
Published: July 2014

SummaryThe International Registry of HLA Epitopes (http://epregistry.com.br) has been recently established as a tool to understand antibody responses to HLA mismatches. These epitopes are defined structurally by three‐dimensional molecular modelling and amino acid sequence differences between HLA antigens. A major goal was to identify HLA epitopes that have been verified experimentally with informative antibodies. This report addresses the identification of MICA epitopes. Our analysis included published information about MICA antibody reactivity in sera from sensitized patients as well as data from our own laboratories. This report describes twenty‐one MICA epitopes verified with antibodies which have primarily been tested in Luminex assays with single alleles. The epitopes correspond to distinct eplets that are often defined by single residues. The Registry is still a work‐in‐progress and will become a useful resource for HLA professionals interested in histocompatibility testing at the epitope level and investigating antibody responses to HLA mismatches in transplant patients.