bluuebunny/crossref_metadata_2025_split huggingface dataset:
A system of evidenced‐based techniques and collaborative clinical interventions with a chronically ill patient
Authors: Fallon Patricia , Wisniewski Lucene 
Published: May 2013

AbstractAlthough evidence‐based treatments (EBTs) exist for both bulimia nervosa and binge eating disorder, there is far less evidence underpinning the treatment of anorexia nervosa (AN). Furthermore, there is no clearly defined standardized approach to patients who have not responded to treatment over an extended period of time. Chronic eating disorder patients in particular might need long‐term engagement with treatment providers offering a wide range of interventions. This case study highlights how an experienced private practitioner systematically employed a variety of EBT techniques for a patient with a severe, long‐term eating disorder and its comorbidities, within a model of attachment and collaboration. The practice of utilizing a wide variety of EBT techniques in a systematic manner guided by clinical expertise and supported by a therapy relationship of collaboration and attachment may prove to be a fruitful avenue for future research. © 2013 by Wiley Periodicals, Inc.
Harnessing the power of technology for the treatment and prevention of eating disorders
Authors: Bauer Stephanie , Moessner Markus 
Published: May 2013

AbstractObjective:The objective of this article is to review the available literature regarding the development and evaluation of technology‐enhanced interventions for eating disorders.Method:Literature was reviewed pertaining to interventions that use technology (e.g., Internet, mobile phones) for prevention, guided self‐help, treatment, relapse prevention, and carer support.Results:A number of technology‐enhanced approaches have been developed for each facet of the care spectrum, and experiences that are reported with their implementation are overall promising. However, only few of them have been evaluated in adequately designed and powered trials.Discussion:This review suggests that technology‐enhanced interventions offer multiple opportunities to improve care for eating disorders. More research is needed on the efficacy, effectiveness, cost‐effectiveness, and reach of these approaches to ultimately estimate their public health impact. It is discussed to what extent innovative models of care integrating technology‐enhanced interventions and face‐to‐face interventions may improve service delivery for eating disorders. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:508–515)
The dissemination and implementation of psychological treatments: Problems and solutions
Authors: Fairburn Christopher G. , Wilson G. Terence 
Published: May 2013

AbstractTreatment researchers expend their efforts identifying effective treatments, and for whom and how they work, but there are matters over and above these that are of concern when it comes to dissemination and implementation. These include the clinical range of the interventions concerned, the ease with which they can be learned, and their mode of delivery. It is these three topics, as they apply to the psychological treatment of eating disorders, that form the focus of this article. Alongside these considerations, we discuss how modern technology has the potential to transform both treatment and training. © 2013 by Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:516–521)
Electrochemical Peroxidase‐Catalase Clark‐Type Biosensor: Computed and Experimental Response
Authors: Kulys Juozas , Bratkovskaja Irina , Ašeris Vytautas , Baronas Romas 
Published: May 2013

AbstractA bioelectrode containing immobilized catalase and peroxidase was built using a Clark‐type oxygen electrode. The bioelectrode responded to hydrogen peroxide (H2O2) as well as to acetaminophen (Ac). The sensitivity of the bioelectrode for H2O2 was 0.35 mM O2/mM H2O2 and for Ac it was 0.23–1.05 µM O2/µM Ac at pH 6.6 and 25 °C. The limit of detection of Ac varied from 12 to 44 µM. The half‐time of the bioelectrode response to hydrogen peroxide was 36 s. The modeling of the bioelectrode action was performed digitally at transition and steady‐state conditions using finite difference technique. The calculated half‐time of the bioelectrode response to hydrogen peroxide was 53 % larger and the steady‐state response 11 % less than experimentally determined. The response to Ac was 2–3 times smaller in comparison to the experimental values. The calculated response change correlated with the experimentally determined when the catalase and peroxidase concentrations in the biocatalytical membrane changed 3–4 orders of magnitude. The simulations of the bioelectrode response revealed that the bioelectrode acts in diffusion limiting conditions at almost all enzymes concentrations. The model appears to be promising for optimization of the bioelectrode response.
Electrogenerated Fe(I) Porphyrins: Efficient Electrocatalysts for Reductive Dechlorination of DDT in N,N′‐Dimethylformamide
Authors: Zhang Ying , Shen Wei , Ou Zhongping , Zhu Weihua , Fang Yuangyuan , Kadish Karl M. 
Published: May 2013

AbstractTwo iron(I) porphyrins were electrogenerated and then utilized as catalysts for the reductive dechlorination of 1,1‐bis(4‐chlorophenyl)‐2,2,2‐trichloroethane (DDT) in N,N′‐dimethylformamide. No reaction is observed between DDT and the Fe(III) or Fe(II) forms of the porphyrin, but the electrogenerated Fe(I) porphyrin efficiently catalyzes the electroreduction of DDT to give (1,1‐bis(4‐chlorophenyl)‐2,2‐dichloroethane) DDD, (1,1‐bis(4‐chlorophenyl)‐2,2‐dichloroethylene) DDE and (1,1‐bis(4‐chlorophenyl)‐2‐dichloroethane) DDMU as determined by GC‐MS analysis. The reductive dechlorination was monitored by electrochemistry, controlled potential electrolysis and spectroelectrochemistry and a mechanism for the reaction involving the reduced porphyrins and DDT is proposed. Comparisons are also made between the catalytic properties of metalloporphyrins containing iron, cobalt and manganese central metal ions under the same solution conditions.
WATER ABSTRACTION CHARGES AS A WATER MANAGEMENT TOOL
Authors: Finney Chris 
Published: May 2013

ABSTRACTThis paper reviews international experience with the use of water abstraction charges (WACs) as a tool for water resource management and a means of recovering the costs involved. It is based on a desk study undertaken to derive guidance for the possible improvement of the WAC system in China and for its use as a demand management tool. At present such charges are confined mainly to high‐ and middle‐income countries. Both the existing use of WACs and their levels of charge vary greatly between countries. A key requirement for their successful implementation is a sound system of water abstraction licensing. Once a licensing system is in operation the marginal costs of introducing abstraction charges are low. In most countries the basic aim of WACs is the recovery of the costs of water resource management. Impacts of abstraction charging on water demand were found generally to be small; only where charges are set at very high levels, far above cost recovery levels, are impacts significant. In most countries such high charges are not politically acceptable. A key requirement for the acceptance of WACs by water users is usually the ‘earmarking’ of the revenue from the charges, so that most is used for water resource‐related purposes. Copyright © 2013 John Wiley & Sons, Ltd.
Can quantitative sensory testing predict responses to analgesic treatment?
Authors: Grosen K. , Fischer I.W.D. , Olesen A.E. , Drewes A.M. 
Published: May 2013

AbstractThe role of quantitative sensory testing (QST) in prediction of analgesic effect in humans is scarcely investigated. This updated review assesses the effectiveness in predicting analgesic effects in healthy volunteers, surgical patients and patients with chronic pain. A systematic review of English written, peer‐reviewed articles was conducted using PubMed and Embase (1980–2013). Additional studies were identified by chain searching. Search terms included ‘quantitative sensory testing’, ‘sensory testing’ and ‘analgesics’. Studies on the relationship between QST and response to analgesic treatment in human adults were included. Appraisal of the methodological quality of the included studies was based on evaluative criteria for prognostic studies. Fourteen studies (including 720 individuals) met the inclusion criteria. Significant correlations were observed between responses to analgesics and several QST parameters including (1) heat pain threshold in experimental human pain, (2) electrical and heat pain thresholds, pressure pain tolerance and suprathreshold heat pain in surgical patients, and (3) electrical and heat pain threshold and conditioned pain modulation in patients with chronic pain. Heterogeneity among studies was observed especially with regard to application of QST and type and use of analgesics. Although promising, the current evidence is not sufficiently robust to recommend the use of any specific QST parameter in predicting analgesic response. Future studies should focus on a range of different experimental pain modalities rather than a single static pain stimulation paradigm.
Metabolic regulation of osteoclast differentiation and function
Authors: Indo Yoriko , Takeshita Sunao , Ishii Kiyo-Aki , Hoshii Takayuki , Aburatani Hiroyuki , Hirao Atsushi , Ikeda Kyoji 
Published: May 2013

ABSTRACT

The osteoclast is a giant cell that resorbs calcified matrix by secreting acids and collagenolytic enzymes. The molecular mechanisms underlying metabolic adaptation to the increased biomass and energetic demands of osteoclastic bone resorption remain elusive. Here we show that during osteoclastogenesis the expression of both glucose transporter 1 (Glut1) and glycolytic genes is increased, whereas the knockdown of hypoxia-inducible factor 1-alpha (Hif1α), as well as glucose deprivation, inhibits the bone-resorbing function of osteoclasts, along with a suppression of Glut1 and glycolytic gene expression. Furthermore, the expression of the glutamine transporter solute carrier family 1 (neutral amino acid transporter), member 5 (Slc1a5) and glutaminase 1 was increased early in differentiation, and a depletion of L-glutamine or pharmacological inhibition of the Slc1a5 transporter suppressed osteoclast differentiation and function. Inhibition of c-Myc function abrogated osteoclast differentiation and function, along with a suppression of Slc1a5 and glutaminase 1 gene expression. Genetic and pharmacological inhibition of mammalian target of rapamycin (mTOR), as well as the activation of adenosine monophosphate (AMP)-activated protein kinase (AMPK), inhibited osteoclastogenesis. Thus, the uptake of glucose and glutamine and utilization of the carbon sources derived from them, coordinated by HIF1α and c-Myc, are essential for osteoclast development and bone-resorbing activity through a balanced regulation of the nutrient and energy sensors, mTOR and AMPK. © 2013 American Society for Bone and Mineral Research
Prevalence, determinants, and inappropriateness of calcium supplementation among men and women in a Spanish Mediterranean area: Cross-sectional data from the ESOSVAL cohort
Authors: Sanfélix-Gimeno Gabriel , Sanfélix-Genovés José , Rodriguez-Bernal Clara L , Peiró Salvador , Hurtado Isabel 
Published: May 2013

ABSTRACT

Recently, safety concerns about calcium supplementation have arisen. In this situation, ensuring appropriateness of use is highly important. We aimed to describe the use of calcium and vitamin D supplements, the factors related to it, and to assess the appropriateness of calcium prescription among men and women aged 50 years or older. We performed a cross-sectional study in 2009–2010 including 11,035 adults who belong to the ESOSVAL cohort and attend 272 primary healthcare centers in the Valencia region of Spain. Criteria for the inappropriateness of calcium prescription, based on guidelines and recent evidence, were: excessive or insufficient daily total intake (diet plus supplements), excessive single doses of supplements, excessive or insufficient association with vitamin D, and overall inappropriateness. Calcium and/or vitamin D were prescribed to about 17% of the population. Older age, antiosteoporotic treatment, use of glucocorticoids, and a diagnosis of osteoporosis were related to prescription. The presence of other secondary causes of osteoporosis determined supplementation only in men. Calcium dietary intake was not related to the prescription of supplements. Among calcium users, 85.8% met at least one criterion of inappropriate prescription; 29% had an inappropriate daily total intake mainly resulting from excessive consumption (&gt;2000 mg/day); 53.8% of patients were given calcium supplements in quantities higher than 500 mg per dose; and 38.9% of individuals receiving calcium supplements had inappropriate (absent or below 800 UI/day) vitamin D supplementation (all of them at high risk). In conclusion, we found high inappropriateness of calcium supplementation, mainly because of calcium overdosing, and also to undertreatment and underdosing of vitamin D in high-risk patients. Physicians should be encouraged to assess calcium dietary intakes before supplementation, recommending intake from food whenever possible, and to prescribe low calcium doses and high vitamin D doses when given in fixed-dose combinations, or vitamin D alone when calcium is not necessary. © 2013 American Society for Bone and Mineral Research
Cardiovascular and renal complications to postsurgical hypoparathyroidism: A Danish nationwide controlled historic follow-up study
Authors: Underbjerg Line , Sikjaer Tanja , Mosekilde Leif , Rejnmark Lars 
Published: May 2013

ABSTRACT

We aimed to identify all patients with postsurgical hypoparathyroidism (HypoPT) and to evaluate their risks of renal complications and cardiovascular disease in relation to their disease and its treatment. We identified possible patients through the Danish National Patient Registry and a prescription database. Case status was adjudicated by review of individual patients' hospital records. For each patient with postsurgical HypoPT due to surgery for nonmalignant diseases between 1988 and 2012, three age-matched (± 2 years) and gender-matched controls were selected from the general background population. The prevalence of postsurgical HypoPT was 22 per 100,000 inhabitants. We identified 688 patients who had undergone neck surgery since 1988 with subsequent hypocalcaemia and inappropriate low parathyroid hormone (PTH) levels that necessitated treatment with calcium and/or vitamin D supplementation for more than 6 months. The average age at diagnosis was 49 years (range, 17–87 years), and 88% were women. Sixteen percent of all patients had had neck surgery prior to the operation causing HypoPT. Compared with controls, patients with HypoPT had an increased risk of renal complications (hazard ratio [HR], 3.67; 95% confidence interval [CI], 2.41–5.59) and hospitalization due to seizures (HR, 3.82; 95% CI, 2.15–6.79), whereas there was no increased risk of cardiac arrhythmias (HR, 1.11; 95% CI, 0.79–1.57) or cardiovascular disease or death (HR, 0.89; 95% CI, 0.73–1.09). In conclusion, although risk of seizures and renal complications is increased, mortality and risk of cardiovascular diseases or arrhythmias is not increased in patients with HypoPT. Further study should try to determine how to reduce the risk of seizures and renal complications in HypoPT. © 2013 American Society for Bone and Mineral Research.
Adsorption of bromophenol blue from aqueous samples by novel supported ionic liquids
Authors: Liu Jiabing , Yao Shun , Wang Litao , Zhu Weixia , Xu Jing , Song Hang 
Published: May 2013

AbstractBACKGROUNDDyeing industry effluent is one of the most problematic waste waters needing to be treated. New adsorption materials, supported ionic liquids (SILs), have been successfully applied for dyes separation.RESULTSIn this study, five SILs including two novel SILs were prepared and characterized by Fourier transform infrared spectroscopy (FT‐IR), elemental analysis, thermogravimetric analysis (TG‐DTA) and nitrogen adsorption–desorption isotherms. The new benzothiazolium hexafluorophosphate‐supported silica (SiO2·Bth+·PF6−) was screened out as the most effective adsorbent for adsorption of bromophenol blue (BPB), and had excellent adsorption and desorption capacity in dynamic adsorption and desorption experiments. It could be reused easily after elution with 0.01 mol L‐1 NaOH. Studies showed that the kinetic data were well described by the pseudo‐second‐order kinetic model. Moreover, the isotherm experiments revealed that the Langmuir model yielded better fitting than the Freundlich model for BPB adsorption. The calculated thermodynamic parameters indicated that the adsorption of BPB was spontaneous and endothermic.CONCLUSIONFive SILs including two novel SILs were prepared and characterized, and their application in the adsorption of BPB was investigated in detail. Among them, SiO2·Bth+·PF6− was found to be the best. This study is expected to be helpful in expanding the type of SILs and their application in the treatment of dyes pollution.© 2013 Society of Chemical Industry
Renal artery stenosis due to fibromuscular dysplasia in a transplanted kidney from a deceased donor: A difficult diagnosis at color doppler ultrasonography
Authors: Venturini M. , Querques G. , Margari S. , Agostini G. , Colombo M. , Caldara R. , Socci C. , De Cobelli F. , Del Maschio A. 
Published: May 2013

ABSTRACTAtherosclerotic renal artery stenosis is a frequent cause of arterial hypertension and/or allograft dysfunction after kidney transplantation and is usually located at the iliac artery anastomosis. Fibromuscular dysplasia is a less frequent, nonatherosclerotic, vascular disease, inducing stenosis at the proximal/mid‐distal part of the renal artery. We report the case of a 44‐year‐old woman, in whom serum creatinine concentration increased and arterial hypertension developed 3 months after renal transplantation. Color Doppler ultrasonography showed a low arterial resistance index and prolonged acceleration time in the interlobar arteries, and a significantly increased peak systolic velocity at the mid third of the renal artery, demonstrating hemodynamically significant stenosis. Percutaneous transluminal angioplasty allowed stenosis correction and was followed by creatinine concentration and arterial blood pressure normalization. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 42:116–120, 2014
Evaluation of ECMWF's soil moisture analyses using observations on the Tibetan Plateau
Authors: Su Z. , de Rosnay P. , Wen J. , Wang L. , Zeng Y. 
Published: May 2013

AbstractAn analysis is carried out for two hydrologically contrasting but thermodynamically similar areas on the Tibetan Plateau, to evaluate soil moisture analysis based on the European Centre for Medium‐Range Weather Forecasts (ECMWF) previous optimum interpolation scheme and the current point‐wise extended Kalman filter scheme. To implement the analysis, this study used two regional soil moisture and soil temperature networks (i.e., Naqu and Maqu) on the Tibetan Plateau. For the cold‐semiarid Naqu area, both ECMWF soil moisture analyses significantly overestimate the regional soil moisture in the monsoon seasons. For the cold‐humid Maqu network area, the ECMWF products have comparable accuracy as reported by previous studies in the humid monsoon period. The comparisons were made among the liquid soil moisture analysis from ECMWF, the ground station's measurements and the satellite estimates from the Advanced Scatterometer sensor. The results show reasonable performances of the ECMWF soil moisture analyses (i.e., both optimum interpolation and extended Kalman filter products) and the Advanced Scatterometer level 2 products, when compared to the in situ measurements.
TPD52 represents a survival factor inERBB2‐amplified breast cancer cells
Authors: Roslan Nuruliza , Bièche Ivan , Bright Robert K. , Lidereau Rosette , Chen Yuyan , Byrne Jennifer A. 
Published: May 2013

AbstractTPD52 and ERBB2 co‐expression has been persistently reported in human breast cancer and animal models of this disease, but the significance of this is unknown. We identified significant positive associations between relativeTPD52andERBB2transcript levels in human diagnostic breast cancer samples, and maximalTPD52expression in the hormone receptor (HR)‐ and ERBB2‐positive sub‐group. High‐levelTPD52expression was associated with significantly reduced metastasis‐free survival, within the overall cohort (log rank test,P = 8.6 × 10−4,n = 375) where this was an independent predictor of metastasis‐free survival (hazard ratio, 2.69, 95% confidence interval 1.59–4.54,P = 2.2 × 10−4,n = 359), and the HR‐ and ERBB2‐positive sub‐group (log rank test,P = 0.035,n = 47). Transient TPD52 knock‐down in theERBB2‐amplified breast cancer cell lines SK‐BR‐3 and BT‐474 produced significant apoptosis, both singly and in combination with transient ERBB2 knock‐down. Unlike ERBB2 knock‐down, transient TPD52 knock‐down produced no reduction in pAKT levels in SK‐BR‐3 or BT‐474 cells. We then derived multiple SK‐BR‐3 cell lines in which TPD52 levels were stably reduced, and measured significant inverse correlations between pERBB2 and TPD52 levels in viable TPD52‐depleted and control cell lines, all of which showed similar proliferative capacities. Our results therefore identify TPD52 as a survival factor inERBB2‐amplified breast cancer cells, and suggest complementary cellular functions for TPD52 and ERBB2. © 2013 Wiley Periodicals, Inc.
Prohibitin‐2 promotes hepatocellular carcinoma malignancy progression in hypoxia based on a label‐free quantitative proteomics strategy
Authors: Cheng Jun , Gao Feng , Chen Xiang , Wu Jian , Xing Chunyang , Lv Zhen , Xu Wei , Xie Qing , Wu Liming , Ye Sunyi , Xie Haiyang , Zheng Shusen , Zhou Lin 
Published: May 2013

AbstractThe rapid growth of hepatocellular carcinoma (HCC) leading to tumor hypoxia is a common pathological phenomenon. Meanwhile, tumor hypoxia can promote a change in the biological properties of tumor cells. It may enhance the survival of tumor cells under stress conditions, resulting in resistance to apoptosis and angiogenesis. The moleculars that could modulate the malignant phenotypes of HCC cells remain largely unknown. Based on label‐free quantitative proteomic data, we found a significant upregulation of prohibitin‐2 (PHB2) in HCC tissues. Treatment of hepatoma cells with small interfering RNAs against PHB2 suppressed cell growth and colony formation, led to G1 phase arrest and sensitized HCC cells to apoptosis. Moreover, inhibition of PHB2 expression dramatically repressed the ability of HCC cells to adapt to hypoxic microenvironments and resist chemotherapy‐induced apoptosis. Thus, PHB2 in HCC supports the development and progression of hepatocellular malignancy to hypoxia, and implicates the potential antagonist function of PHB2 in transarterial chemoembolization treatment. © 2013 Wiley Periodicals, Inc.