bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abnormal hippocampal morphology in dissociative identity disorder and post‐traumatic stress disorder correlates with childhood trauma and dissociative symptoms
Authors: Chalavi Sima , Vissia Eline M. , Giesen Mechteld E. , Nijenhuis Ellert R.S. , Draijer Nel , Cole James H. , Dazzan Paola , Pariante Carmine M. , Madsen Sarah K. , Rajagopalan Priya , Thompson Paul M. , Toga Arthur W. , Veltman Dick J. , Reinders Antje A.T.S. 
Published: December 2014

AbstractSmaller hippocampal volume has been reported in individuals with post‐traumatic stress disorder (PTSD) and dissociative identity disorder (DID), but the regional specificity of hippocampal volume reductions and the association with severity of dissociative symptoms and/or childhood traumatization are still unclear. Brain structural magnetic resonance imaging scans were analyzed for 33 outpatients (17 with DID and 16 with PTSD only) and 28 healthy controls (HC), all matched for age, sex, and education. DID patients met criteria for PTSD (PTSD–DID). Hippocampal global and subfield volumes and shape measurements were extracted. We found that global hippocampal volume was significantly smaller in all 33 patients (left: 6.75%; right: 8.33%) compared with HC. PTSD–DID (left: 10.19%; right: 11.37%) and PTSD‐only with a history of childhood traumatization (left: 7.11%; right: 7.31%) had significantly smaller global hippocampal volume relative to HC. PTSD–DID had abnormal shape and significantly smaller volume in the CA2‐3, CA4‐DG and (pre)subiculum compared with HC. In the patient groups, smaller global and subfield hippocampal volumes significantly correlated with higher severity of childhood traumatization and dissociative symptoms. These findings support a childhood trauma‐related etiology for abnormal hippocampal morphology in both PTSD and DID and can further the understanding of neurobiological mechanisms involved in these disorders. Hum Brain Mapp 36:1692–1704, 2015. © 2014 Wiley Periodicals, Inc.
The Implications of Sarcopenia and Sarcopenic Obesity on Cardiometabolic Disease
Authors: Kim Tae Nyun , Choi Kyung Mook 
Published: December 2014

ABSTRACTThe important changes in body composition associated with aging are a decline in skeletal muscle mass and an increase in body fat. Body fat distribution also changes with age; subcutaneous fat decreases and visceral abdominal fat increase, which contributes to numerous cardiometabolic diseases (CMDs) such as type 2 diabetes, dyslipidemia, and cardiovascular disease (CVD). Sarcopenia often accompanied by an increase in body fat and vice versa, a scenario termed sarcopenic obesity (SO), which might lead to the cumulative risk of both sarcopenia and obesity. However, there is still no consensus regarding the definition and consequences of SO. The lack of a unified definition for SO might contribute to inconsistent findings about the association of SO with CMD. Complex etiologies are associated with development of SO. A vicious cycle between the loss of muscle and the accumulation of ectopic fat might be associated with CMD via an intricate interplay of factors including proinflammatory cytokines, oxidative stress, mitochondrial dysfunction, insulin resistance, dietary energy, physical activity, mitochondrial dysfunction, and other factors that have yet to be identified. Moreover, recent epidemiological studies suggest that SO is related to CVD and mortality. This review focuses on the current literature with regard to the association between sarcopenia, dynapenia, and obesity, as well as their implications for CMD. The ultimate goal of this Prospects is to encourage conduct of well‐designed future studies that elucidate the relationship among sarcopenia, SO, and CMD. J. Cell. Biochem. 116: 1171–1178, 2015. © 2014 Wiley Periodicals, Inc.
Biochemical investigations of human papillomavirus‐infected cervical fluids
Authors: Choi Samjin , Park Hun‐Kuk , Min Gyeong Eun , Kim Yeon‐Hee 
Published: December 2014

ABSTRACTPurpose: Cervical cancer is caused by persistent infection with high‐risk types of human papillomavirus (HPV). The aim of this study was to investigate the potential of Raman spectroscopy as a stand‐alone analytical tool for clinical diagnosis of HPV infection using human cervical fluids. Method: A drop‐coating deposition surface‐enhanced Raman scattering (DCD‐SERS) method was identified as the most effective method of biochemical analysis in cervical biofluids. Results: Using a 2‐µL sample, the proposed DCD‐SERS method yielded Raman spectra with high reproducibility, noise‐independence, and uniformity. Additionally, the produced spectra were independent of the volume of fluid used and detection zone analyzed within the central and the ring zones. The optical detection of HPV infection in cervical fluids could be detected accurately in the central zone. Different Raman spectra were obtained according to HPV type. In particular, HPV‐16 and HPV‐18, which are the major risk factors for cervical cancer, showed a distinct spectral difference in cervical fluids, with a similar pattern for high Raman bands at >1,000 cm−1 but a different pattern for low Raman bands at <1,000 cm−1. Therefore, all ranges of HPV‐gated DCD‐SERS could be used to detect the presence of HPV infection. Conclusions: Raman spectroscopy provides a good alternative method for early clinical diagnosis of HPV infection, and we are hopeful that this proposed method of HPV assessment will be approved for use in obstetrics and gynecology clinics. Microsc. Res. Tech., 2014. © 2014 Wiley Periodicals, Inc. Microsc. Res. Tech. 78:200–206, 2015. © 2014 Wiley Periodicals, Inc.
Laparoscopic pancreatic reconstruction technique following laparoscopic pancreaticoduodenectomy
Authors: Kang Chang Moo , Lee Sung Hwan , Chung Myung Jae , Hwang Ho Kyoung , Lee Woo Jung 
Published: December 2014

AbstractWith the advance of laparoscopic experiences and techniques, it is carefully regarded that laparoscopic pancreaticoduodenectomy (lap‐PD) is feasible and safe in managing perimapullary pancreatic pathology. Especially, laparoscopic management of remnant pancreas can be a critical step toward completeness of minimally invasive PD. According to available published reports, there is a wide range of technical differences in choosing surgical options in managing remnant pancreas after lap‐PD. For the evidence‐based surgical approach, it would be ideal to test potential techniques by randomized controlled trials, but, currently, it is thought to be very difficult to expect those clinical trials to be successful because there are still a lack of expert surgeons with sound surgical techniques and experience. In addition, lap‐PD is so complicated and technically demanding that many surgeons are still questioning whether this surgical approach could be standardized and popular like laparoscopic cholecystectomy. In general, surgical options are usually chosen based on following question: (1) Is it simple? (2) Is it easy and feasible? (3) Is it secure and safe? (4) Is there any supporting scientific evidence? It would be interesting to estimate which surgical technique would be appropriate in managing remnant pancreas under these considerations. It is hoped that a well standardized multicenter‐based randomized control study would be successful to test this fundamental issues based on sound surgical techniques and scientific background.
Neutrophil to lymphocyte ratio predicts pattern of recurrence in patients undergoing liver resection for colorectal liver metastasis and thus the overall survival
Authors: Giakoustidis Alexandros , Neofytou Kyriakos , Khan Aamir Z. , Mudan Satvinder 
Published: December 2014

ObjectiveWe investigate the neutrophil to lymphocyte ratio (NLR) as a potential prognostic factor for patients undergoing curative liver resection for colorectal liver metastasis (CRLM).MethodsWe identified patients who underwent liver resection, via our prospectively accumulated surgical database at the Royal Marsden Hospital and The London Clinic, by two liver surgeons (SM and AZK) between January 2005 and December 2012 and patients included had liver resection for CRLM and received preoperative chemotherapy with an NLR > 2.5 considered elevated. NLR's role in disease‐free, post‐recurrence and overall survival was determined by univariate and multivariate Cox regression models.ResultsOne hundred and sixty nine patients were enrolled. Seventy‐one patients (42%) demonstrated NLR > 2.5. Elevated NLR was associated with decreased OS in univariate and multivariate analysis (HR 2.12; 95% CI, 1.18–3.82; P = 0.012) but not with DFS. Analyzed as continuous variable, higher NLR was associated with decreased OS(HR 1.17; 95% CI, 1.03–132; P = 0.011) and associated with increased risk of extrahepatic/multifocal recurrence (P = 0.007), linked in this way with a decreased post‐recurrence survival (HR 1.24, 95% CI, 1.02–1.52; P = 0.032).ConclusionsElevated NLR in patients who undergo hepatectomy following neoadjuvant chemotherapy for CRLM increases risk of extrahepatic/multifocal recurrence and is an independent predictor of overall survival. J. Surg. Oncol. 2015 111:445–450. © 2014 Wiley Periodicals, Inc.
Developing a prognostic model for localized Ewing sarcoma family of tumors: A single institutional experience of 224 cases treated with uniform chemotherapy protocol
Authors: Biswas Bivas , Rastogi S. , Khan S.A. , Shukla N.K. , Deo S.V.S. , Agarwala S. , Mohanti B.K. , Sharma M.C. , Vishnubhatla Sreenivas , Bakhshi S. 
Published: December 2014

BackgroundData on patients with localized Ewing sarcoma family of tumors (ESFT) who have received a uniform chemotherapy protocol are minimal.MethodsThis is a single institutional review of patients with ESFT treated between June 2003 and November 2011.Results224/374 (60%) patients with ESFT presented with localized disease; median age was 15 years (range: 0.1–55). Ninety‐nine patients underwent surgery of which 50 received adjuvant radiotherapy; 80 patients received radical radiotherapy following neoadjuvant chemotherapy. At median follow‐up of 40.2 months (range: 1.3–129), 5‐year EFS, OS, and local‐control‐rate, were 36.8 ± 3.6%, 52.4 ± 4.3%, and 63 ± 4.3%, respectively. In multivariate analysis, tumor diameter >8 cm (P = 0.03), symptom duration >4 months (P = 0.04), and WBC >11 × 109/L (P = 0.003) predicted inferior EFS; spine/abdomino‐pelvic primary (P = 0.009) and WBC >11 × 109/L (P = 0.003) predicted inferior OS. Tumor size >8 cm (P = 0.03) and radical radiotherapy as local treatment (P = 0.01) predicted inferior local‐control‐rate.ConclusionPrognostic hazard models for EFS and OS based on significant prognostic factors suggested that patients with combination of ESFT of spine/abdomino‐pelvic region and baseline WBC >11 × 109/L had inferior OS (hazard ratio 4.44, P < 0.001) while patients with combination of ESFT with symptom duration >4 months, tumor diameter >8 m and baseline WBC >11 × 109/L had inferior EFS (hazard ratio 3.89, P = 0.002). J. Surg. Oncol. 2015 111:683–689. © 2014 Wiley Periodicals, Inc.
Sarcopenia is an independent predictor of complications following pancreatectomy for adenocarcinoma
Authors: Joglekar Savita , Asghar Aeen , Mott Sarah L. , Johnson Benjamin E. , Button Anna M. , Clark Eve , Mezhir James J. 
Published: December 2014

Background and ObjectivesSarcopenia, which is subclinical loss of skeletal muscle mass, is commonly observed in patients with malignancy. The objective of this study is to determine the correlation between sarcopenia and operative complications following pancreatectomy for cancer.MethodsA retrospective review of a pancreatectomy database was performed. The Hounsfield Unit Average Calculation (HUAC) of the psoas muscle, a marker of muscle density and fatty infiltration, was measured from preoperative CT scans. Complications were graded and multivariate logistic regression analysis was performed.ResultsOne hundred eighteen patients met criteria for analysis; the overall morbidity rate was 78.8% (n = 93). There were 31 (26.3%) patients who met criteria for sarcopenia using the HUAC. When analyzed as a continuous variable, sarcopenia was an independent predictor of major grade III complications, length of stay, intensive care unit admission, delayed gastric emptying, and infectious, gastrointestinal, pulmonary, and cardiac complications.ConclusionsThese data suggest that sarcopenia as measured with the HUAC, a value that can be obtained from a preoperative CT scan, is a significant independent predictor of surgical outcome and can be used to improve patient selection and informed consent prior to pancreatectomy in patients with cancer. J. Surg. Oncol. 2015 111:771–775. © 2014 Wiley Periodicals, Inc.
Role of radiation therapy for non‐extremity soft tissue sarcomas
Authors: De Amorim Bernstein Karen , Delaney Thomas F. 
Published: December 2014

BackgroundNegative surgical margins are uncommon for non‐extremity soft tissue sarcomas. Radiation therapy is usually recommended to improve local control; however, appropriate RT dosing is challenging due to nearby dose‐limiting normal structures.Material and MethodsComprehensive literature search using PubMed (March 2014).ResultsData suggest radiation therapy is an important modality in maximizing local tumor control in non‐extremity sarcomas.ConclusionThe literature supports the use of RT to improve local control for non‐extremity soft tissue sarcomas. J. Surg. Oncol. 2015 111:604–614. © 2014 Wiley Periodicals, Inc.
Significance of diabetes on morbidity and mortality following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy
Authors: Randle Reese W. , Ahmed Shuja , Levine Edward A. , Fino Nora F. , Swett Katrina R. , Stewart John H. , Shen Perry , Votanopoulos Konstantinos I. 
Published: December 2014

Background and ObjectivesPatients with diabetes suffering from peritoneal surface disease represent a challenge to treat due to the effects of both processes on multiple organ systems. We sought to define the impact of diabetes on outcomes following cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC).MethodsA retrospective analysis of a prospective database of 1065 CRS/HIPEC procedures was conducted. Patient demographics, comorbidities, and tumor characteristics were reviewed.ResultsCRS/HIPEC was performed in 91 diabetic and 844 non‐diabetic patients with peritoneal surface disease from 1991 to 2013. Diabetics and non‐diabetics spent 6.8 and 3.1 (P = 0.009) days in the ICU, respectively. Diabetics were more likely to suffer major complications (P < 0.001) including infectious (P < 0.001) and thrombotic (P = 0.05) complications, arrhythmias (P = 0.007), renal insufficiency (P = 0.002) and respiratory failure (P = 0.002) than non‐diabetics. Mortality was significantly worse for diabetic patients at 30‐days (8.8% vs. 2.7%, P = 0.007) and at 90‐days (13.2% vs. 5.2%, P = 0.008). Even after adjusting for other significant predictors of morbidity, diabetes predicted more major complications and increased mortality following CRS/HIPEC.ConclusionsDiabetes predicts major complications and specific complication patterns associated with increased ICU stay and worse mortality in patients undergoing CRS/HIPEC. Diabetic patients deemed to be appropriate candidates for CRS/HIPEC should be treated with caution. J. Surg. Oncol. 2015 111:740–745. © 2014 Wiley Periodicals, Inc.
Visible red light enhances physiological anagen entry in vivo and has direct and indirect stimulative effects in vitro
Authors: Sheen Yi‐Shuan , Fan Sabrina Mai‐Yi , Chan Chih‐Chieh , Wu Yueh‐Feng , Jee Shiou‐Hwa , Lin Sung‐Jan 
Published: December 2014

Background and ObjectivesHair follicles are located at the interface of the external and internal environments and their cycling has been shown to be regulated by intra‐ and extra‐follicular factors. The aim of this study is to examine whether or how hair follicles respond to visible light.Study Design/Materials and MethodsWe examined the effect of 3 mW red (630 nm, 1 J/cm2), 2 mW green (522 nm, 1 J/cm2), and 2 mW blue light (463 nm, 1 J/cm2) on telogen in mice for 3 weeks. The photobiologic effects of red light on cell proliferation of outer root sheath keratinocytes and dermal papilla cells were studied in vitro.ResultsWe found that red light accelerated anagen entry faster than green and blue light in mice. Red light irradiation stimulated the proliferation of both outer root sheath keratinocytes and dermal papilla cells in a dose‐dependent manner by promoting cell cycle progression. This stimulative effect was mediated via extracellular signal‐regulated kinase phosphorylation in both cells. In a co‐culture condition, dermal papilla cells irradiated by red light further enhanced keratinocyte proliferation, suggesting enhanced epithelial‐mesenchymal interaction. In search for factors that mediated this paracrine effect, we found fibroblast growth factor 7 was upregulated in both mRNA and protein levels. The stimulative paracrine effect on keratinocytes was significantly inhibited by neutralizing antibody against fibroblast growth factor 7.ConclusionsThese results suggest that hair follicles respond to visible light in vivo. Red light may promote physiological telogen to anagen transition by directly stimulating outer root sheath keratinocytes and indirectly by enhancing epithelial‐mesenchymal interaction in vitro. Lasers Surg. Med. 47:50–59, 2015. © 2014 Wiley Periodicals, Inc.
Effect of university heritage and reputation on attitudes of prospective students
Authors: Merchant Altaf , Rose Gregory M. , Moody Geoffrey , Mathews Lucy 
Published: December 2014

This study examines the impact of heritage and reputation of nonprofit universities on attitudes of prospective students. Data were collected from 208 community college (preuniversity) students in the USA. Results from structural equations modeling indicate that university heritage positively impacts university reputation, potential students' attitudes, and intentions to pay a tuition premium as well as to recommend the university. Students' nationality moderates the relationships between university heritage, reputation, and attitudes. International students from Asian nations with a long‐term orientation exhibit stronger relationships between these variables than domestic students from the USA. These findings add to the nascent and emerging literature on branding of nonprofit higher education institutions and will be of interest to administrators and marketing managers of universities to nurture and extol their university heritage in student recruitment programs, especially in promotional materials targeting international students. Copyright © 2014 John Wiley & Sons, Ltd.
Long horizon input parameterisations to enlarge the region of attraction of MPC
Authors: Khan B. , Valencia‐Palomo G. , Rossiter J. A. , Jones C. N. , Gondhalekar R. 
Published: December 2014

SummaryIn this paper, the efficacy of structured and unstructured parameterisations of the degree of freedom within a predictive control algorithm is investigated. While several earlier papers investigated the enlargement of the region of attraction using structured prediction dynamics, little consideration has been given to the potential of unstructured parameterisations to handle the trade‐off between the region of attraction, performance and computational burden. This paper demonstrates how unstructured dynamics can be both selected and used effectively and furthermore gives a comparison with structured methods. Copyright © 2014 John Wiley & Sons, Ltd.
Quantifying photovoltaic fire danger reduction with arc‐fault circuit interrupters
Authors: Armijo Kenneth M. , Johnson Jay , Harrison Richard K. , Thomas Kara E. , Hibbs Michael , Fresquez Armando 
Published: December 2014

AbstractUnmitigated arc‐faults present fire dangers, shock hazards, and cause system downtime in photovoltaic (PV) systems. The 2011 National Electrical Code® added section 690.11 to require a listed arc‐fault protection device on new PV systems. Underwriters Laboratories created the outline of investigation for PV DC arc‐fault circuit protection, UL 1699B, for certifying arc‐fault circuit interrupters (AFCIs) for arc suppression. Unfortunately, little is known about appropriate trip times for arc‐faults generated at different locations in the PV system, with different electrode and polymer encapsulant geometries and materials. In this investigation, a plasma model was developed, which determines fire danger with UL 1699B‐listed AFCIs and consequences of arc‐fault discharges sustained beyond UL 1699B trip time requirements. This model predicts temperatures for varying system configurations and was validated by 100 and 300 W arc‐faults experiments where combustion times and temperatures were measured. This investigation then extrapolated burn characteristics using this model to predict polymer ignition times for exposure to arc‐power levels between 100 and 1200 W. The numerical results indicate AFCI maximum trip times required by UL 1699B are sufficient to suppress 100–1200 W arc‐faults prior to fire initiation. Optical emission spectroscopy and thermochemical decomposition analysis were also conducted to assess spectral and chemical degradation of the polymer sheath. Published 2014. This article has been contributed to by US Government employees and their work is in the public domain in the USA.
Aza‐Michael addition reaction: Post‐polymerization modification and preparation of PEI/PEG‐based polyester hydrogels from enzymatically synthesized reactive polymers
Authors: Hoffmann Christian , Stuparu Mihaiela C. , Daugaard Anders , Khan Anzar 
Published: December 2014

ABSTRACTThe utility of aza‐Michael addition chemistry for post‐polymerization functionalization of enzymatically prepared polyesters is established. For this, itaconate ester and oligoethylene glycol are selected as monomers. A Candida Antarctica lipase B catalyzed polycondensation reaction between the two monomers provides the polyesters, which carry an activated carbon‐carbon double bond in the polymer backbone. These electron deficient alkenes represent suitable aza‐Michael acceptors and can be engaged in a nucleophilic addition reaction with small molecular mono‐amines (aza‐Michael donors) to yield functionalized linear polyesters. Employing a poly‐amine as the aza‐Michael donor, on the other hand, results in the formation of hydrophilic polymer networks. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 745–749
Effect of geometric imperfections on aluminium silo capacities
Authors: Górski Jarosław , Mikulski Tomasz , Oziębło Magdalena , Winkelmann Karol 
Published: December 2014

AbstractAn aluminium silo with initial imperfections is analysed. Two types of imperfection are considered. The first one takes the form of local indentations in the shell; their size and range are adopted on the basis of the standard guidelines. The second type is a global imperfection described through the use of its eigenforms and by means of two‐dimensional random fields. The calculations are limited to two cases of loading: negative pressure and wind. The choice of the loading has been suggested in Eurocodes. In the case of wind load, the probability distribution of its direction is taken into account.Einfluss geometrischer Imperfektionen auf die Belastbarkeit von Aluminium‐Silokonstruktionen. Ein Aluminium‐Silo mit anfänglichen Imperfektionen wird untersucht. Zwei Typen von Imperfektion werden angenommen. Der erste Typ sind lokale Vertiefungen der Hülle. Ihre Größe und Anordnung werden auf Grundlage von Normrichtlinien festgesetzt. Der zweite Typ ist eine globale Imperfektion, die mittels ihrer Eigenformen und zweidimensionaler Zufallsfelder beschrieben wird. Die Berechnungen sind auf zwei Lastfälle beschränkt, negativer Druck und Wind. Die Auswahl der Belastung wurde in Eurocodes vorgeschlagen. Bei der Windlast wird die Wahrscheinlichkeitsverteilung der Windrichtung berücksichtigt.