bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sequence-Specific Alterations of Epitope Production by HIV Protease Inhibitors
Authors: Kourjian Georgio , Xu Yang , Mondesire-Crump Ijah , Shimada Mariko , Gourdain Pauline , Le Gall Sylvie 
Published: March 2014

Abstract
Ag processing by intracellular proteases and peptidases and epitope presentation are critical for recognition of pathogen-infected cells by CD8+ T lymphocytes. First-generation HIV protease inhibitors (PIs) alter proteasome activity, but the effect of first- or second-generation PIs on other cellular peptidases, the underlying mechanism, and impact on Ag processing and epitope presentation to CTL are still unknown. In this article, we demonstrate that several HIV PIs altered not only proteasome but also aminopeptidase activities in PBMCs. Using an in vitro degradation assay involving PBMC cytosolic extracts, we showed that PIs altered the degradation patterns of oligopeptides and peptide production in a sequence-specific manner, enhancing the cleavage of certain residues and reducing others. PIs affected the sensitivity of peptides to intracellular degradation, and altered the kinetics and amount of HIV epitopes produced intracellularly. Accordingly, the endogenous degradation of incoming virions in the presence of PIs led to variations in CTL-mediated killing of HIV-infected cells. By altering host protease activities and the degradation patterns of proteins in a sequence-specific manner, HIV PIs may diversify peptides available for MHC class I presentation to CTL, alter the patterns of CTL responses, and provide a complementary approach to current therapies for the CTL-mediated clearance of abnormal cells in infection, cancer, or other immune disease.
Magnetic Resonance Imaging of Deep Infiltrating Endometriosis: Comparison of 2DT2- and 3DT2-Weighted TSE Sequences
Authors: Busard Milou P. , Pieters-Van Den Bos Indra C. , Van Kuijk Cornelis , Van Waesberghe Jan hein H. 
Published: March 2014

Purpose The purpose of this study was to compare image quality and diagnostic confidence of 3DT2 (SPACE) and 2DT2 magnetic resonance (MR) imaging for the evaluation of deep infiltrating endometriosis (DIE). Methods A total of 121 patients, referred for MR imaging because of suspected DIE with bowel involvement, underwent both 2DT2 and 3DT2 MR imaging. Two independent readers assessed both datasets for presence of DIE, artefacts and overall image quality. Inter-rater agreement scores were calculated using Cohen's kappa, and image quality and diagnostic confidence scores were compared using the Wilcoxon rank sum test. Results Inter-rater agreement scores for diagnosis of DIE (located retrocervical/vaginal cuff, or involving the bowel or bladder) using both 3DT2 SPACE and 2DT2, or solely 3DT2 and 2DT2 were excellent. Diagnostic confidence scores were similar for 3DT2 and 2DT2. Analysis of the 3DT2 dataset in combination with 2DT2 showed significant higher diagnostic confidence compared with solely 2DT2 for 1 location, which differed per reader. In 2DT2, artefacts were significantly lower, and overall image quality was significantly higher (p<0.01 and p<0.001, respectively). Conclusions Although 3DT2 SPACE could replace routine 2DT2-weighted imaging, the authors prefer 2DT2 over 3D, because of significantly fewer artefacts and a higher overall image quality with almost similar diagnostic confidence scores. Thus 3DT2 might be added to the standard protocol in indistinct cases.
Brachial Artery Aneurysms following Brachio-cephalic AV Fistula Ligation
Authors: Khalid Usman , Parkinson Frances , Mohiuddin Kamran , Davies Paula , Woolgar Justin 
Published: March 2014

Purpose Peripheral artery aneurysms proximal to a long-standing arteriovenous (AV) fistula can be a serious complication. It is important to be aware of this and manage it appropriately. Methods Vascular access nurses input all data regarding patients undergoing dialysis access procedures into a securely held database prospectively. This was retrospectively reviewed to identify cases of brachial artery aneurysms over the last 3 years. Results In Morriston Hospital, around 200 forearm and arm AV fistulas are performed annually for vascular access in renal dialysis patients. Of these, approximately 15 (7.5%) are ligated. Three patients who had developed brachial artery aneurysms following AV fistula ligation were identified. All 3 patients had developed brachial artery aneurysms following ligation of a long-standing brachio-cephalic AV fistula. Two patients presented with pain and a pulsatile mass in the arm, and one presented with pins and needles and discoloration of fingertips. Two were managed with resection of the aneurysm and reconstruction with a reversed long saphenous vein interposition graft, the third simply required ligation of a feeding arterial branch. Conclusions True aneurysm formation proximal to an AV fistula that has been ligated is a rare complication. There are several reasons for why these aneurysms develop in such patients, the most plausible one being the increase in blood flow and resistance following ligation of the AV fistula. Of note, all the patients in this study were on immunosuppressive therapy following successful renal transplantation. Vigilance by the vascular access team and nephrologists is paramount to identify those patients who may warrant further evaluation and investigation by the vascular surgeon.
Evaluation for Hypoperfusion Distal to Arteriovenous Vascular Access Using Skin Perfusion Pressure in Fingers
Authors: Tanaka Akihito , Sakakibara Masaki , Nishimura Hayato , Asano Marina , Kariya Tetsuyoshi , Masamoto Daijiro , Mizutani Makoto , Ishii Hideki , Murohara Toyoaki 
Published: March 2014

Purpose The usefulness of skin perfusion pressure (SPP) measurement in the assessment of critical ischemia of the lower limb has previously been established. This study investigated whether finger SPP measurement is useful to evaluate hypoperfusion distal to arteriovenous vascular access in dialysis patients. Methods Seventeen asymptomatic hemodialysis patients with upper extremity arteriovenous access and 17 non-dialysis control patients were prospectively examined. SPP in the thumb, the middle finger and the little finger of both hands was measured. The bilateral difference of the mean SPP of the three fingers was evaluated. Results The mean difference of SPP between the contralateral and the arteriovenous access sides among hemodialysis patients (33±2 5 mmHg) was significantly larger than the mean difference of SPP between the left and the right hands among control patients (1.0±6.0 mmHg, p<0.01). Conclusions This report shows the potential usefulness of SPP measurement to evaluate hypoperfusion distal to arteriovenous vascular access.
1961-2011 : Cinquante ans, six programmes de formation en bibliothéconomie et sciences de l’information à l’Université de Montréal
Authors: Hudon Michèle 
Published: March 2014

En 2011, l’École de bibliothéconomie et des sciences de l’information (EBSI) célébrait 50 ans d’intégration à l’Université de Montréal. Au cours de cette période, l’École a offert successivement six programmes d’études principaux : un programme de baccalauréat de 1961 à 1970 et cinq programmes de maîtrise depuis, le plus récent implanté en 2009. Le présent article précise d’abord les facteurs qui mènent à la restructuration ou au remplacement d’un programme d’études et explique les étapes du processus. Il décrit brièvement la structure de chacun des programmes et compare la liste des cours obligatoires qui en était une composante importante. Il évoque finalement quelques-uns des défis auxquels sont confrontés les responsables de la formation des futurs professionnels des sciences de l’information.
The Uses of Copper and Zinc Aluminates to Capture and Convert Carbon dioxide to Syn-gas at Higher Temperature
Authors: Raskar R. Y. , Gaikwad A. G. 
Published: March 2014

The uses of copper and zinc aluminates to capture and convert the CO2 to syn-gas were studied at higher temperatures. The samples of copper and zinc aluminates were prepared by solid-solid fusion method by calcining in air at 900 oC for 3 h. Those samples were characterized by acidity/alkalinity, surface area, XRD pattern, IR, SEM images and screening to capture CO2 at the different temperatures. The phases Cu2O, CuO, ZnO, CuAl2O4 and ZnAl2O4 were found to be in the samples of zinc and copper aluminates. Acidity and surface area of the samples of copper and zinc aluminates were found to be in the ranges from 0.063 to 9.37 mmol g-1 and 3.04 to 11.8 m2 g-1, respectively. The captured CO2 by the samples of copper and zinc aluminates was found to be 19.92 to 31.52 wt% for the temperature range 40 to 850 oC. The captured CO2 at 550 oC by variable Zn/Al and Cu/Al mol ratio from 0.5 to 6 of the samples of copper and zinc aluminates was found to be 12.81 to 18.04 wt%. The reduction of carbon dioxide by zinc and copper aluminates was observed. The conversion of CO2 by methane over variable mol ratio of Cu/Al and Zn/Al in copper and zinc aluminates, respectively, at 500 oC showed the production of syn-gas by using the gas hourly space velocities (GHSV) 12000, 12000 and 6000 ml. h-1. g-1 of helium, CO2 and methane. The conversions of CO2 by methane over the samples of zinc and copper aluminates were studied at different mol ratios of CO2 to methane. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Enolisation Kinetics of m-Nitro Acetophenone
Authors: Swati Malhotra Swati Malhotra , Jaspal Dipika 
Published: March 2014

m-Nitroacetophenone was chosen for the study of kinetics of enolisation. The rate of the reaction was studied by iodination. The kinetics of the reaction was monitored under several conditions of variation of ketone concentration, dielectric constant of the medium , temperature, effect of catalyst etc. In addition to this four different amino acids viz. β-alanin, DL-alanin, L-alanin and Glycine were tested as catalyst for the enolisation process. The rate of enolisation was found to increase with the increase in then ketone concentration , percentage composition of the solvent mixture and also with the increase in the dipole moments of the amino acids. Pseudofirst order rate kinetics was operational and the rate constants were found to increase with the increase in the amino acid molarity. Linear plots obtained for log of rate constants versus reciprocal of temperature which were in good agreement with Arrhenius equation. The values of thermodynamic parameters like Entropy (∆S≠) , Enthalpy (∆H≠), energy of activation (∆Ea) and Free energy(∆F≠) were calculated and were found to be 2.6186 e.u. , 20.85 e.u. ,23.46 k cal mol-1 and 20.0 k cal mol-1 respectively. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
The Photocatalytic Activity of SiO2-TiO2/Graphite and Its Composite with Silver and Silver oxide
Authors: Rahmawati Fitria , Wahyuningsih Sayekti , Irianti Dian 
Published: March 2014

This research study the mixed semiconductor of SiO2-TiO2 which was immobilized on graphite substrate and also studies the effect of surface modification on its mixed semiconductor. The surface modification was carried out by electrode position of Ag from 0.4 M of AgNO3 solution at various applied current. The electrode position was conducted for 30 minutes at 0.004; 0.008; 0.010; 0.012 and 0.014 A. In the electrode position cell, SiO2-TiO2/Graphite was used as cathode and a graphite rod was used as anode. The weight of deposited Ag was analyzed gravimetrically. The current efficiency of electrode position was calculated by comparing its experimental weight to its theoretical weight founded from calculation using Faraday’s equation for electrolytic cell. Meanwhile, the photo electrochemical testing was carried out to investigate the efficiency of induced photon to current conversion; it was measured as %IPCE (% Induced Photon to Current Efficiency). The crystallinity and crystal structure of the prepared materials were analyzed by X-ray diffraction and their surface morphology was analyzed by Scanning Electron Microscope (SEM). This research found that silver was deposited as silver metal, Ag and as silver oxide, AgO. The electrode position efficiency at applied current of 0.014 A is 92.30 % with diameter of cluster is 7 - 11.9 mm. It is founded that Ag and AgO deposition enhanced the efficiency of photon conversion into current up to 89.92 %. The optimum %IPCE value is at 28.6 % of Ag content. Ag-SiO2-TiO2/G has higher photo conversion than Ag-TiO2/G, shown by the %IPCE value at 300 nm is 83.25 % higher than Ag-TiO2/G. It indicates the significant role of silica network in photo excitation mechanisms in the composite material. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Modification of Turen Bentonite with AlCl3 for Esterification of Palmitic Acid
Authors: Abdulloh Abdullah , Maryam Siti , Aminah Nanik Siti , Triyono Triyono , Trisunaryanti Wega , Mudasir Mudasir , Didik Prasetyoko Didik Prasetyoko 
Published: March 2014

Natural Turen bentonite has been modified and applied as catalyst for palmitic acid esterification. Modification of natural Turen bentonite was conducted by cation exchange method using AlCl3 solution. Catalyst characterization was performed on X-ray Fluoroscence, X-ray Diffraction, nitrogen adsorption-desorption and infrared spectroscopy techniques. The catalytic activity test in the esterification reaction of palmitic acid with methanol was conducted by bath at 65 °C with a variation of reaction time of 1, 2, 3, 4 and 5 h. Catalytic activity has been observed qualitatively using GC-MS and quantitatively by changes in acid number. The analysis showed the formation of Al3+-bentonite. Observation on the elements has shown that the presence of calcium decreased from 10.2% to 4.17%, with an increase of aluminium content from 9.9% to 13%. Diffraction line at 2θ 5.7379º became 5.6489º, along with changes in d-spacing of 15.3895 Å to 15.6319 Å. The surface area increased from 83.78 m2/g to 91.26 m2/g, while Brönsted acid sites increased from 10.2 µmol/g to 67.5 µmol/g and Lewis acid sites increased from 94.9 µmol/g to 132 µmol/g. Furthermore, Al3+-bentonite has showed as active catalyst in the esterification reaction of palmitic acid with palmitic acid with conversion of 78.78% for 5 h. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Development of Nanoporous Ni-Sn Alloy and Application for Chemoselective Hydrogenation of Furfural to Furfuryl Alcohol
Authors: Rodiansono Rodiansono , Hara Takayoshi , Ichikuni Nobuyuki , Shimazu Shogo 
Published: March 2014

A very simple synthetic procedure was developed for the preparation of Ni-Sn alloy catalysts that were utilised for chemoselective hydrogenation of furfural, producing furfuryl alcohol almost exclusively. The mixture of nickel nanoparticles supported on aluminium hydroxide (R-Ni/AlOH) and a solution containing tin was treated under hydrothermal condition, producing the as prepared nickel-tin alloy supported on aluminium hydroxide (Ni-Sn/AlOH). H2 treatment at range of temperature of 673-873 K for 1.5 h to the as prepared Ni-Sn/AlOH produced nanoporous Ni-Sn alloy catalysts. XRD patterns and SEM images revealed that the formation of Ni-Sn alloy of Ni3Sn and Ni3Sn2 phases and the transformation of crystalline gibbsite and bayerite into amorphous alumina were clearly observed after H2 treatment at 873 K. The formation of the Ni-Sn alloy may have played a key role in the enhancement of the chemoselectivity. © 2014 by Authors, Published by BCREC Group. This is an open access article under the CC BY-SA License (https://creativecommons.org/licenses/by-sa/4.0)
Set‐membership parity space approach for fault detection in linear uncertain dynamic systems
Authors: Blesa Joaquim , Puig Vicenç , Saludes Jordi , Fernández‐Cantí Rosa M. 
Published: March 2014

SummaryIn this paper, a set‐membership parity space approach for linear uncertain dynamic systems is proposed. First, a set of parity relations derived from the parity space approach is obtained by means of a transformation derived from the system characteristic polynomial. As a result of this transformation, parity relations can be expressed in regressor form. On the one hand, this facilitates the parameter estimation of those relations using a zonotopic set‐membership algorithm. On the other hand, fault detection is then based on checking, at every sample time, the non‐existence of a parameter value in the parameter uncertainty set such that the model is consistent with all the system measurements. The proposed approach is applied to two examples: a first illustrative case study based on a two‐tank system and a more realistic case study based on the wind turbine fault detection and isolation benchmark in order to evaluate its effectiveness. Copyright © 2014 John Wiley & Sons, Ltd.
A new approach for motion capture using magnetic field : models, algorithms and first results
Authors: Aloui Saifeddine , Villien Christophe , Lesecq Suzanne 
Published: March 2014

SummaryIndoor and outdoor applications such as sports and health monitoring as well as realistic 3D movie and game animations require ambulatory motion capture. Thus, creating a new low‐cost light‐weight wearable motion capture system that offers realistic motion estimates is of great interest. This paper presents a new approach for ambulatory human motion capture, featuring a body mounted magnetic field source and magnetic field sensors together with an estimation algorithm. A complete study of the model, the hardware, and the estimation algorithms is presented. Results obtained in the context of motion capture of human upper limbs illustrate the proposed approach.Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis of 3‐Arylated 3,4‐Dihydrocoumarins: Combining Continuous Flow Hydrogenation with Laccase‐Catalysed Oxidation
Authors: Suljić Sanel , Pietruszka Jörg 
Published: March 2014

AbstractA convenient arylation of diverse 3,4‐dihydrocoumarins with a number of catechols is described leading to a new class of compounds. As key step, a laccase‐catalysed oxidation/Michael addition sequence is applied using commercially available laccase from Agaricus bisporus. 3,4‐Dihydrocoumarins were obtained in a rapid and facile two‐step sequence starting from salicylaldehydes: The corresponding coumarins were synthesised through a Knoevenagel condensation in up to 83% yield followed by a quantitative reduction performed in a flow system. Combining the reductive flow reaction with the laccase‐catalysed arylation also led to successful consecutive one‐pot approaches. Overall, the enzyme‐catalysed arylations were carried out with yields ranging from 63 to 94%.magnified image
Die Rolle der Ligandenfeldzustände im ultraschnellen photophysikalischen Zyklus der Eisen(II)‐Spinübergangsverbindung [Fe(ptz)6](BF4)2
Authors: Marino Andrea , Chakraborty Pradip , Servol Marina , Lorenc Maciej , Collet Eric , Hauser Andreas 
Published: March 2014

AbstractDer LIESST‐Effekt (“light‐induced excited spin state trapping”) in Eisen(II)‐Spinübergangsverbindungen, das heißt, die lichtinduzierte Population des High‐spin‐Zustands (S=2) unterhalb der thermischen Übergangstemperatur, wurde vor 30 Jahren entdeckt. Für die Einstrahlung in Metall‐Ligand‐Charge‐Transfer(MLCT)‐Banden der Low‐spin‐Spezies (S=0) geht die anerkannte Relaxationskaskade in etwa 150 fs vom ursprünglich angeregten 1MLCT‐Zustand über den 3MLCT‐Zustand direkt in den High‐spin‐Zustand, wobei die tiefenergetischen Ligandenfeld(LF)‐Zustände umgangen werden. Die Beobachtung von LIESST und reverse‐LIESST mittels Einstrahlung direkt in die LF‐Banden in Systemen mit nur hochenergetischen MLCT‐Zuständen zeigt, dass diese dennoch eine Rolle spielen. Hier identifizieren wir den ersten angeregten S=1‐LF‐Zustand als Zwischenzustand mit einer Lebensdauer von 39 ps in der Kaskade von reverse‐LIESST, die auf die Anregung in den spinerlaubten LF‐Übergang der high‐spin Spezies im NIR folgt.
Total Synthesis of (±)‐Clavilactones A, B, and Proposed D through Iron‐Catalyzed Carbonylation–Peroxidation of Olefin
Authors: Lv Leiyang , Shen Baojian , Li Zhiping 
Published: March 2014

AbstractBiologically significant clavilactones A, B, and the previously proposed D have been synthesized through iron‐catalyzed carbonylation–peroxidation of a 1,5‐diene. Three steps from aldehydes, alkenes, and tert‐butylhydroperoxide build up α,β‐epoxy‐γ‐butyrolactone skeleton as a key building block for synthesis of clavilactone family and its derivatives. Based on our results, the structure of the proposed clavilactone D is not correct and requires revision.
Hydrophobic Actuation of a DNA Origami Bilayer Structure
Authors: List Jonathan , Weber Michael , Simmel Friedrich C. 
Published: March 2014

AbstractAmphiphilic compounds have a strong tendency to form aggregates in aqueous solutions. It is shown that such aggregation can be utilized to fold cholesterol‐modified, single‐layered DNA origami structures into sandwich‐like bilayer structures, which hide the cholesterol modifications in their interior. The DNA bilayer structures unfold after addition of the surfactant Tween 80, and also in the presence of lipid bilayer membranes, with opening kinetics well described by stretched exponentials. It is also demonstrated that by combination with an appropriate lock and key mechanism, hydrophobic actuation of DNA sandwiches can be made conditional on the presence of an additional molecular input such as a specific DNA sequence.
The Origin of Shape Sensitivity in Palladium‐Catalyzed Suzuki–Miyaura Cross Coupling Reactions
Authors: Collins Gillian , Schmidt Michael , O'Dwyer Colm , Holmes Justin D. , McGlacken Gerard P. 
Published: March 2014

AbstractThe shape sensitivity of Pd catalysts in Suzuki–Miyaura coupling reactions is studied using nanocrystals enclosed by well‐defined surface facets. The catalytic performance of Pd nanocrystals with cubic, cuboctahedral and octahedral morphologies are compared. Superior catalytic reactivity is observed for Pd NCs with {100} surface facets compared to {111} facets. The origin of the enhanced reactivity associated with a cubic morphology is related to the leaching susceptibility of the nanocrystals. Molecular oxygen plays a key role in facilitating the leaching of Pd atoms from the surface of the nanocrystals. The interaction of O2 with Pd is itself facet‐dependent, which in turn gives rise to more efficient leaching from {100} facets, compared to {111} facets under the reaction conditions.