bluuebunny/crossref_metadata_2025_split huggingface dataset:
INFANTILE DIGITAL FIBROMATOSIS
Authors: Watanabe Hideko , Nagao Sadanori , Inaba Shogo , Iijima Susumu 
Published: April 2015

ABSTRACTIn a case of infantile digital fibromatosis in a 5‐month‐old female baby, there were lesions on the digits, and later a tumor recurred on the sole. From histological, histochemical and electron microscopic testing, it is suggested that the specific inclusion was composed of peptide with little or no sugar or nucleic acid content and that it was an accumulation of “immature” tropocollagen. A brief review of the literature is presented.
ANALYSIS OF THE BINDING SITES OF PHYTOHEMAGGLUTININS AND PEMPHIGUS ANTIBODY IN THE INTERCELLULAR AREAS OF THE EPIDERMIS
Authors: Nishikawa Takeji , Harada Takashi , Hatano Hitoshi , Ogawa Hideoki , Miyazaki Hiroaki 
Published: April 2015

ABSTRACTIn order to characterize the pemphigus antigen(s), the binding sites of phytohemagglutinins and pemphigus antibody were studied by the combined use of fluorescein‐labelled Concanavalin A (Con A‐FITC), Phytohemagglutinin‐P‐FITC (PHA‐P‐FITC) and pemphigus antibody. Reciprocal blocking test of PHA‐P and pemphigus antibody revealed that the binding sites of PHA‐P and pemphigus antibody were independent, whereas those of Con A and pemphigus antibody were very closely related though not identical. Pemphigus skin with deposition of IgG or with presumable saturation of the binding sites with high‐titred antibody showed capability to Con A binding. Treatment of normal skin sections with Hyaluronidase or Neuraminidase did not supply any clue to the histochemical analysis of pemphigus antigen(s), since the binding sites of pemphigus antibody were destroyed in the buffer, prior to the enzyme digestion. These results suggested that the binding sites of pemphigus antibody in the intercellular areas consist, at least, of carbohydrates or glycoproteins that contain alpha‐methyl‐D‐mannoside or alpha‐methyl‐D‐glucoside.
ELUTION OF SOLUBLE EPIDERMAL GLYCOPROTEINS BINDING WITH CONCANAVALIN A AND STUDIES ON THEIR REACTIVITY WITH PEMPHIGUS ANTIBODY
Authors: Miyagawa Sachiko , Hayashi Koji , Sakamoto Kuniki 
Published: April 2015

ABSTRACTSoluble epidermal glycoproteins reactive with Concanavalin A (Con A) were eluted by means of affinity chromatography using Con A‐conjugated Sepharose 4B. Studies on their immunogenicity and antigenicity revealed that the main components of pemphigus antigens are not identical with surface saccharides reactive with Con A.
IMMUNE DEPOSITS IN THE SKIN OF REVERSED PASSIVE ARTHUS REACTION. THE EFFECTS OF THE ADMINISTRATION OF THE CORTICOSTEROID
Authors: Kubo Miyoko , Ueki Hiroaki , Nohara Nozomi 
Published: April 2015

ABSTRACTThe effects of corticosteroid administration on the immune deposits in the skin of reversed passive Arthus reaction (RPAR) using horseradish peroxidase as antigen were studied. Immune deposits were seen on vascular walls, on collagen fibers, at the dermo‐epidermal junction, at perifollicular regions, on mononuclear cells and in PMN‐leukocytes. By corticosteroid administration the amount of these immune deposits was most obviously reduced within the first 30 minutes after the induction of the RPAR. At 1, 4, 8, 24 and 48 hours after induction of the reaction there were no significant differences in the amount and the extent of the immune deposits on the vascular walls, on the collagen fibers and on the mononuclear cells, between the sections treated by corticosteroid and those of non‐treated specimens. The infiltration of PMN‐leukocytes and their uptake of immune complexes were maximum at 4 hours after the injection and the number of these infiltrated PMN‐leukocytes and the amount of immune complexes which were taken by them were slightly reduced by corticosteroid administration.
THE PROGNOSIS OF SKIN CARCINOMA AND MALIGNANT MELANOMA WITH SPECIAL REFERENCE TO THEIR EXTENTS AS REPRESENTED IN TERMS OF T, N, AND M OF UNION INTERNATIONALE CONTRE LE CANCER (UICC)
Authors: Imai Seiji 
Published: April 2015

ABSTRACTThe prognosis of skin carcinoma and malignant melanoma was studied statistically. One hundred and one cases of basal cell epithelioma (BCE), 93 cases of squamous cell carcinoma (SCC), and 34 cases of malignant melanoma (MM) were studied. No cases of death due to basal cell epithelioma were found. The squamous cell carcinomas and malignant melanomas were classified according to the TNM system into three classes with different prognoses.The first class represents the initial stage, in which cure is expected if treatment is adequate. The second class is the intermediate stage, in which cure is uncertain and the prognosis depends upon the degree of extension. The third class is the late stage, in which distant metastasis is found and in which cure might not be anticipated. Furthermore, the prognosis of previously treated cases was poorer than that of untreated cases.Our findings indicate that early diagnosis and appropriate treatment in the initial stage results in the best prognosis and that the success or failure of the initial treatment has an appreciable influence on the prognosis of skin malignancy.
MUCOPOLYSACCHARIDOSIS WITH SPECIAL REFERENCE TO SCHEIE SYNDROME
Authors: Horiuchi Ryuya , Ishikawa Hidekazu , Ishii Yoko , Watanabe Yuko , Noguchi Tetsuro , Suzuki Shigeoki 
Published: April 2015

ABSTRACTThree patients with Scheie syndrome are reported on. They were suspected to be suffering from mucopolysaccharidosis because of clinical, histological and electron microscopic observations. The Scheie syndrome diagnosis was based on urinary GAG analysis. Chase experiments with cultured fibroblasts from one of the patients showed retarded degradation of 85SO4‐labeled intracellular GAG. In addition, the pathogenesis of mucopolysaccharidoses in connection with cellular GAG metabolism is discussed.
TRANS‐EPIDERMAL ELIMINATION OF IMMUNE DEPOSITS IN THE SKIN. AN IMMUNOHISTOCHEMICAL STUDY ON IMMUNE DEPOSITS USING HORSERADISH PEROXIDASE AS ANTIGEN
Authors: Ueki Hiroaki , Kubo Miyoko , Masuda Toshiki , Nohara Nozomi 
Published: April 2015

ABSTRACTUsing horseradish peroxidase (HRP) as antigen, reversed passive Arthus reactions were carried out on the skin of rabbits, in which HRP‐anti HRP immune deposits were observed as brownish granules in sections treated with diaminobenzidine and peroxide. Some immune deposits, presumably insoluble immune complexes, were found to be taken up by neutrophilic leukocytes in the subepidermal papillary layer, then pushed up into the epidermal layer and subsequently eliminated from the epidermal surface as small crusts.In the course of this trans‐epidermal elimination, intra‐epidermal and subcorneal micro‐abscesses were observed. Most of the neutrophilic leukocytes in the micro‐abscesses were shown to contain peroxidase‐positive granules. The trans‐epidermal elimination of immune deposits might represent a way of biological clearance of immune deposits occurring in the sub‐epidermal papillary layer or within the epidermis.
TREATMENT OF MYCOSIS FUNGOIDES WITH OK‐432
Authors: Sawada Yoko , Ohashi Masaru 
Published: April 2015

ABSTRACTUp to the present no other therapeutic means besides local X‐ray or beta‐ray irradiation and anticancer drugs for the treatment of patients with mycosis fungoides, especially when the condition has progressed to secondary involvement of the lymph nodes, has been found.A recent clinical trial of OK‐432 injected locally into cutaneous tumors of a patient with this disease resulted in a conspicuous contraction not only of the tumors injected but of other tumors as well along with significant regression of lymphadenomas. No serious adverse reaction was observed other than low‐grade fever and heavy‐headedness.These results suggest host‐mediated and direct antitumor effects of OK‐432 as the possible underlying mechanisms. The efficacy of OK‐432 in reducing the size of the tumors without causing any serious adverse effects indicate the potential usefulness of this drug for the treatment of mycosis fungoides.
Angiolipoma In Brothers
Authors: Namba Masako , Kohda Mamoru , Mimura Shigeru , Nakagawa Shôjiro , Ueki Hiroaki 
Published: April 2015

ABSTRACTTwo brothers with angiolipoma are presented. The patients, 33‐ and 37‐year‐old men, have multiple subcutaneous nodules on the trunk and extremities. Skin biopsies have confirmed the diagnosis of angiolipoma.
A CASE OF LICHEN MYXEDEMATOSUS ASSOCIATED WITH IMMUNOLOGICAL ABNORMALITIES
Authors: Akiyama Tomio , Hori Makoto , Yamaura Hideaki , Nonaka Shigeo , Takahashi Isamu 
Published: April 2015

ABSTRACTA 33‐year‐old male consulted us with symptoms of band‐like infiltration, thickenning and subcutaneous induration occurring in the face, chest, back, shoulder and upper extremities. In the following time he developed arthralgia, fever and ocular symptoms. Laboratory tests revealed normal thyroid functions and a normal bone marrow picture, but there were immunological abnormalities such as reduced cellular immunity, decrease in C 3 (beta 1c/1a) and positive antinuclear antibody. Histologically, there was an increase in fibroblasts and deposits of hyaluronic acid were revealed histochemically. A diagnosis of lichen myxedematosus was established.At present, all symptoms and signs including skin rash have disappeared following corticosteroid therapy and the patient is being followed up. So far as we have been able to trace, reports on lichen myxedematosus associated with immunological abnormalities as described here have not been found. The relationship between this pathology and immunological abnormalities are discussed.
EXFOLIATIVE DERMATITIS FROM CHINESE HERBS (DECOCTION)
Authors: Watanabe Chiyeko , Kawada Akihiro 
Published: April 2015

ABSTRACTA patient, aged 78, with exfoliative dermatitis due to the ingestion of Chinese herbs (decoction) was presented. Provocative medication showed that he was sensitive to 4 composite materials (Radix angelicae acutilobae, Rhizoma zingiberis, Radix paeoniae and Radix glycyrrhizae). Patch tests were positive to each of these materials while the intradermal test was negative. These results indicate that systemic contact‐type hypersensitivity to the ingested medicines is involved in evoking the exfoliative dermatitis lesion and that, in addition, purely epidermal contact sensitivity as defined by S. Epstein and Baer plays an important role.
EPIDEMIOLOGICAL ASPECTS OF HOUSE DUST ALLERGY IN NIGERIA
Authors: Hunponu‐Wusu O.O. , Somorin A.O. 
Published: April 2015

ABSTRACTDuring an investigation of the mite fauna in Lagos, Nigeria, the following mites, namely, Dermatophagoides, Blomia, Cheyletus and Mesostigmata species were isolated. Blomia species, a hitherto undocumented mite in Nigeria occurs to a marked extent in Nigerian houses. It was observed that location of houses seemed to affect the density and types of mites and that the majority of the houses were located in the damper suburbs of the city. It is suggested that in the prophylaxis of dust‐induced allergic diseases maintainance of adequate housing conditions would be of epidemiological importance. Furthermore, in the prevention of the occupational hazard of dust‐induced asthma, it is recommended that routine medical examination of prospective employees, particularly those in dust‐associated industries, should include pre‐employment allergic skin testing in order to ascertain sensitivity to industrial dusts.
HYPERGAMMAGLOBULINEMIC PURPURA AND CRYOGLOBULINEMIA
Authors: Sonnenblick Moshe , Gelmont David , Jacobsohn Warren Z , Rachmilewitz Eliezer 
Published: April 2015

ABSTRACTPrimary hypergammaglobulinemic purpura in an 84 year old woman is described. In addition to her advanced age, she also showed cryoglobulinemia. The patient was further studied by immunofluorescent staining of the skin biopsy specimen, which showed deposition of IgG, IgM, fibrinogen and β1C in the vessel walls.These findings would seem to indicate involvement of the complement system in the pathogenesis of the vasculitis in this entity.
ELECTRON MICROSCOPIC STUDY OF SEBACEOUS EPITHELIOMA
Authors: Hori Makoto , Egami Kazuya , Maejima Kazuki , Nishimoto Katsutaro 
Published: April 2015

ABSTRACTA case of sebaceous epithelioma on the scalp of a 50 year old female was reported.Using an electron microscope, cells from the tumor were classified into 5 stages according to their development.Furtheremore, our investigation indicate that lipid synthesis was activated in sebaceous epithelioma cells rather than in normal sebaceous cells, and can apparently be distinguished from lipid‐droplet formation by degradation.These sebaceous epithelioma cells also possessed the ability to secrete which suggests that these tumor cells originated from germinative cells of the sebaceous gland rather than epidermal basal cells.
THE “COLLOID BODY”—ITS NATURE AND PATHOGENESIS—
Authors: Ishibashi Yasumasa , Tsuru Noriko , Kukita Atsushi 
Published: April 2015

ABSTRACTThe so‐called “colloid bodies” in lichen planus and lichen amyloidosus were observed ultrastructurally and compared with the changes of basal cells in “Futorafur dermatitis”, which occurs after long term administration of N1‐(2′‐tetrahydrofuryl‐5‐fluorouracil).The “colloid bodies” were located in the intercellular spaces in the epidermis and freely in the stroma of the upper corium. They were mainly composed of fine filaments, and frequently contained some melanosomes, mitochondria and other vacuolated structures. These filaments had a constant width about 70 to 80 Å in diameter, which was much the same as those of tonofilaments in an adjacent keratinocytes. A number of desmosomes, to which these filaments convergently adhered, were occasionally observed in “colloid bodies”. This finding seems to support the theory that these filaments are themselves tonofilaments originating from keratinocytes, and they are fundamentally differentiated from other types of filaments in the dermo‐epidermal junction areas. The degenerative processes of basal cells in the epidermis in the lesions of “Futorafur dermatitis” seemed to be identical to those in formation of “colloid bodies” from keratinocytes in lichen planus.
ENZYMOLOGICAL STUDIES OF EPIDERMAL ACID PHOSPHATASE
Authors: Miyagawa Teruo , Nakayama Juichiro , Toshitani Shoji , Ogura Ryohei 
Published: April 2015

ABSTRACTAcid phosphatase of newborn rat epidermis was purified about 270‐fold by a procedure including acid treatment, CM‐cellulose, DEAE‐cellulose chromatography, and gel filtration on Sephadex G‐100. The purified enzyme had a pH optimum of 5.0 and an optimal temperature of 40°C. The enzyme was not activated by divalent cations, ethylenediaminetetraacetic acid or 2‐mercaptoethanol, and it was inhibited by p‐chloromercuribenzoate. The inhibition pattern by fluoride and by L(+) tartrate was competitive. The Km value for p‐nitrophenyl phosphate was 3.84×10−5 M, and the molecular weight was about 73, 000. The enzyme appeared to be a nonspecific acid phosphatase. Intracellular localization of acid phosphatase in the epidermis was discussed.
ULTRASTRUCTURE OF SO‐CALLED MULTICENTRIC PIGMENTED BOWEN'S DISEASE
Authors: Kimura Shunji 
Published: April 2015

ABSTRACTTwo cases of so‐called multicentric pigmented Bowen's disease were examined by electron microscopy. The three types of genital lesions found in Case 1, including typical black papules, whitish macerated papules and brownish‐black papillomatous lesions, showed both dyskeratotic features which were less pronounced than those of ordinary Bowen's disease, and virus‐like particles in the nuclei of the keratinocytes beneath the horny layer. On the other hand, the two types of lesions in Case 2 showed similar features, although dyskeratotic features were not apparently observed. These results suggest that the three types of genital lesions in Case 1 are similar to each other, and also to extragenital lesions, which were also present, and that there may be a common pathogenetic factor, probably human papilloma virus.
ANTI‐DNA ANTIBODIES OF VARIOUS SKIN DISEASES, ESPECIALLY OF SYSTEMIC LUPUS ERYTHEMATOSUS
Authors: Idemori Masahiro , Hanamiya Hideaki , Yasaka Shoko , Kudo Shoichiro , Arao Tatsuyoshi 
Published: April 2015

ABSTRACTAnti‐DNA antibodies of healthy controls and patients with various skin diseases, especially with SLE, were measured with a hemoagglutination test using erythrocytes labelled with DNA (DNA test manufactured by Fujizoki). The following conclusions were obtained. 1) Untreated SLE with acute symptoms presents a high anti‐DNA antibody titer in the DNA test. 2) The anti‐DNA antibody titer rises slightly later than do clinical symptoms. 3) If corticosteroids are given in sufficient doses at the beginning of SLE treatment, there is a possibility of the DNA test turning negative within two months. 4) The anti‐DNA antibody titer is kept at a dilution of 1:160 or less in well‐controlled SLE. 5) In addition to SLE, PSS also gives increased titers.
BEHAVIOR OF PIGMENT CELLS ON LESIONS OF THE PIGMENTED NEVUS WITH VITILIGO
Authors: Hamada Toshio , Sakurane Hirotada F. , Saito Tadao 
Published: April 2015

ABSTRACTWhen vitiligo occurred on lesions of the pigmented nevus, the behavior of pigment cells in this nevus was investigated. Three cases of giant hairy nevi, seven cases of moles, three cases of Mongolian spots and eleven specimens in nine cases of halo nevi were used. Giant hairy nevi combining with vitiligo showed intensive decreases in nevus cells, particularly superficial A and B‐type nevus cells. The epidermal dopa‐positive melanocytes and melanin granules in the epidermis decreased, but still remained. On the other hand, moles in vitiligo showed an almost complete disappearance of epidermal dopa‐positive melanocytes and melanin granules in the epidermis; nevus cells in the dermis decreased only slightly. Mongolian spots with vitiligo showed an epidermis similar to vitiligo, but the dermal melanocytes were hardly changed. Halo nevi exhibited an intensive decrease and degeneration of nevus cells and marked lymphocytic infiltration. Some of them showed disappearance of epidermal dopa‐positive melanocytes and melanin granules in the epidermis.The characteristic findings of vitiliginous skin are mostly restricted to epidermis. In contrast, however, it is interesting to note that, on the lesions of nevocellular nevi with vitiligo, the dermis also exhibited some decrease and degeneration of nevus cells and lymphocytic infiltration.
PLASMA MEMBRANE ULTRASTRUCTURE OF THE HUMAN SKIN KERATINOCYTE AS OBSERVED BY FREEZE‐FRACTURE ELECTRON MICROSCOPY
Authors: Kitajima Yasuo , Mori Shunji 
Published: April 2015

ABSTRACTThe ultrastructure of the plasma membrane of human keratinocytes was investigated by freeze‐fracture electron microscopy. Desmosomes were identified as an intramembranous particle aggregation on both of the fracture faces of the plasma membrane. The particle density of desmosomes ranged from 1,100 to 1,500/μ2, while those of the P and E faces of the non‐desmosomal membrane areas were 350 and 100/μ2, respectively. The size of desmosomes varied from 0.3 to 0.7 μ in diameter. The frequency of the desmosomes was one to two per 2 μ2. Gap junctions were a hexagonal array of the intramembranous particles in freeze‐fracture replicas, and found much less frequently than desmosomes. On the basal cell membranes, round pits due to pinocytosis and particle aggregates of hemidesmosomes were observed.
ENZYMATIC STUDIES ON ADNEXAL TUMORS OF THE SKIN
Authors: Aoyagi Takashi , Kobayashi Hitoshi , Kamigaki Katsuko , Miura Yusho 
Published: April 2015

ABSTRACTSebaceous gland carcinoma (SGC), basal cell epithelioma with sebaceous cell differentiation (BCE+S) and basal cell epithelioma (BCE) were examined enzymatically, in order to elucidate the enzymatic characteristics of these tumors and the tumor cell origin of BCE+S.SGC demonstrated significantly higher enzyme activity of glucose‐6‐phosphate dehydrogenase (G‐6‐PDH), isocitrate dehydrogenase (ICDH) and α‐glycerophosphate dehydrogenase (Gly‐PDH) than did BCE.BCE+S had an enzymatic pattern similar to BCE, except for Gly‐PDH which resembled SGC.The results obtained in this study indicated that BCE+S derived not from sebaceous gland cells but from primitive basal cells or epidermal cells which transformed into BCE and then partially differentiated toward sebaceous gland cells.
EPIDERMODYSPLASIA VERRUCIFORMIS—REPORT OF A CASE AND GENETIC CONSIDERATION ON THE JAPANESE CASES—
Authors: Yoshikawa Kunihiko , Maeda Naonori , Kato Takehisa 
Published: April 2015

ABSTRACTThirty three Japanese cases recorded in the last 10 years are reviewed with an additional case of a 57‐year‐old Japanese woman with typical eruptions and cutaneous malignancies.Familial occurrence and parental consanguinity were seen in at least 30.0% and 26.7% of the cases respectively, further suggesting the recessive mode of inheritance which affects males and females almost equally.Cutaneous malignancy was seen in 48.5% of these patients with an average age of 35.3 yrs.
PSORIATIC ARTHRITIS
Authors: Nigam Pranesh , Singh Dinesh , Matreja V.S. , Saxena H.N. 
Published: April 2015

ABSTRACTA less documented entity of psoriatic arthritis was studied in 238 cases of psoriasis and it was detected in 5.1% of cases. The prevalence of arthritis was found in the population over 40 years of age and was 2.7% of the males and 8.2% of the females. Psoriatic arthritis was much more common in females (male to female ratio=1:2) in contrast to male predominance in psoriasis (male to female ratio=1.6:1). Skin lesions usually precede the arthritis (50%); in others the onset is synchronous (41.7%) and in few of them the arthritis may come first (8.3%). Athritis is commonly encountered with moderate to severe involvement of skin (75%). In deforming type of arthritis the psoriasis was extensive and exfoliative (17%). The nails are more frequently involved at the onset of the arthritis. Rose‐Waaler Test was negative in all of them. Anaemia (41.6%) and raised ESR (25%) was a feature in the active phase of the disease. Hyperurecaemia was noted in 41.6% of cases, indicating towards the extensive involvement of skin. The importance of radiological evaluation of spine, sterno‐clavicular and sacro‐iliac joints in all patients is stressed. Certain unusual features noted in the presented series of cases are; calcaneal spur (17%), spondylolisthesis (8.5%) and presence of LE cells (8.3%).
ULTRASTRUCTURAL OBSERVATIONS OF PAUTRIER MICROABSCESS
Authors: Sagami Seichiro , Asano Shoichi , Takahashi Masanobu , Imabayashi Kazumi 
Published: April 2015

ABSTRACTThe skin of a 56‐year‐old Japanese male with mycosis fungoides (MF), tumor stage, was examined by electron microscopy. The results obtained were as follows:

Mycosis fungoides cells (MC) were present singly and also as a migratory pattern in the basal cell layer of the epidermis.
MC had increased in number by migration from the dermis and probably by mitosis in the epidermis to form a group in the upper layer of the epidermis.
The wall of an established Pautrier microabscess (PM) was tight and continuous in appearance with high electron density, and consisted of the cell membranes of the surrounding keratinocytes.
There were morphologically two types of MC in PM, clear and dark; The difference between the two was due to intracellular organelles, and could be a representation of each functional phase.
Based on the findings in the literature and those in the present study, the histogenesis of PM was discussed.