bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acoustic characteristics of voluntary expiratory sounds after swallow for detecting dysphagia
Authors: Yamashita M. , Yokoyama K. , Takei Y. , Furuya N. , Nakamichi Y. , Ihara Y. , Takahashi K. , Groher M. E. 
Published: May 2014

SummaryThis research was designed to investigate the acoustic characteristics of voluntary expiratory sounds after swallow for detecting dysphagia. Forty‐nine patients with complaints of swallow difficulty received a videofluorographic (VF) examination. They were divided into three groups: nine who did not have any apparent disease (Group N), 22 patients with head and neck cancer (Group H&N) and 18 patients with other diseases including cerebrovascular disease (Group OD). After liquid barium swallows, they exhaled voluntarily without voicing. Videofluorographic findings were classified into four groups: normal (Normal), acceptable swallow (Acceptable), swallow with residue (Resid) and swallows with penetration or aspiration (Pen/Asp). The duration of expiratory sounds was measured on the time waveform. Frequency characteristics of expiratory sounds were obtained using one‐third octave band analysis ranging from 62·5 to 2000·0 Hz of central frequency. The averaged level of the 1000·0‐Hz band was chosen as the reference band level (RB level). The revised averaged level of each band was obtained by subtracting the RB level from the averaged level of each band. Zero decibel of the revised magnitude of the 125·0‐Hz band was set as the critical value to differentiate dysphagia (Resid or Pen/Asp) from no dysphagia (Normal or Acceptable). Comparison of this assessment with VF findings showed a significant percentage agreement (85·4%). These results suggest that frequency characteristics of post‐swallow expiratory sounds can differentiate dysphagia from no dysphagia among multiple dysphagic patient groups.
Bisexuality and Suicide: A Systematic Review of the Current Literature
Authors: Pompili Maurizio , Lester David , Forte Alberto , Seretti Maria Elena , Erbuto Denise , Lamis Dorian A. , Amore Mario , Girardi Paolo 
Published: May 2014

Abstract

Introduction
Many studies of lesbian, gay, and bisexual youth have demonstrated that individuals reporting a bisexual orientation have a particularly high risk of suicidal behavior and substance abuse. It has been also suggested that bisexual individuals (both men and women) have higher rates of depression and anxiety compared with homosexual and heterosexual groups.

Aim
The aim of the present article was to determine whether or not an association between bisexuality and suicidal behavior exists and to analyze risk factors for suicidal behavior in bisexual individuals.

Main Outcome Measures
The combined search strategies yielded a total of 339 records screened from PubMed, Scopus, and Web of Knowledge. Duplicate articles, articles that were not in English, and those that did not analyze bisexuality separately from homosexuality were excluded. A quality assessment was performed for each study included.

Methods
A careful systematic review of the literature was conducted investigating the potential bisexuality-suicidal behavior link. A total of 77 articles from peer-reviewed journals were considered, and the most relevant (N = 19) were selected for this review.

Results
Individuals reporting a bisexual orientation had an increased risk of suicide attempts and ideation compared with their homosexual and heterosexual peers. Risk factors included related victimization, peer judgments, and family rejection. Bisexual individuals also reported higher rates of mental illness and substance abuse.

Conclusions
Bisexual individuals may experience more psychological distress and mental health problems than individuals who identify with a homosexual or heterosexual orientation. Clinicians should consider the potential for suicidal behaviors in bisexual individuals and be alert for increased mental health problems and poor social integration.
Same-Session Dorsal Vein Ligation and Testing by Intracavernous Injection Prior to Penile Prosthesis Implantation (DVL-ICI-PPI)
Authors: Shaeer Osama , Shaeer Kamal 
Published: May 2014

Abstract

Introduction
Complications of penile prosthesis implantation (PPI) are rare, nevertheless can be grave. In cases with veno-occlusive dysfunction (VOD), alternative surgical techniques such as dorsal vein ligation (DVL) are controversial. Some patients may opt for trial at DVL to avoid the possible complications of PPI. However, this may be associated with disappointment if DVL fails and another procedure is required.

Aim
The aim if this study is to evaluate the results of a combined approach involving DVL, same-session testing by intracavernous injection (ICI) of prostaglandin E1 (PGE1), and immediate implantation of a penile prosthesis (PPI) in case of poor response to DVL.

Main Outcome Measures
Long-term erectile function in cases with favorable intraoperative response to DVL.

Methods
Twenty-six patients with refractory VOD were operated upon. Through a peno-pubic incision, DVL was performed, followed by ICI of 20 µg PGE1 in two divided doses, 10 µg each, 15 minutes apart. Group 1 exhibited full rigidity in response to the first dose. Group 2 exhibited full rigidity in response to the second dose. PPI was not performed for either. Group 3 exhibited suboptimal response to both doses, and PPI was performed through the same incision. Patients were followed up from 24 to 48 months using International Index of Erectile Function-5 scoring.

Results
For Group 1 (n = 8), six patients experienced normal erectile function following DVL throughout the whole follow-up period of 48 months (23.1% of all patients), and two patients relapsed. Group 2 (n = 6) (23.1%) reported normal erectile function for an average of 6 months, then relapsed. Group 3 (n = 12) had a penile prosthesis implanted in the same setting.

Conclusion
Combined DVL-ICI-PPI can spare around 23.1% of young patients with VOD from PPI, at no additional risk. Full response to 10 µg PGE1 at intraoperative testing carries good prognosis to DVL on the long run. Investigation of a larger number of patients is necessary before reaching a final conclusion.
Activation of β-Adrenergic Receptors During Sexual Arousal Facilitates Vaginal Lubrication by Regulating Vaginal Epithelial Cl− Secretion
Authors: Sun Qing , Huang Jiehong , Yang Deng-Liang , Cao Xiao-Nian , Zhou Wen-Liang 
Published: May 2014

Abstract

Introduction
Vaginal lubrication, an indicator of sexual arousal and tissue health, increases significantly during genital sexual arousal. Adrenergic alpha-receptors (AR) are an important regulator of genital physiological responses involved in mediating vascular and nonvascular smooth muscle contractility; the role of β-AR in sexual arousal, however, has not yet been investigated.

Aim
The goal of this study was to reveal the functional role of β-AR in modulating vaginal lubrication during sexual arousal and the mechanisms underlying the process.

Methods
The effects of adrenaline on vaginal epithelial ion transport, intracellular cyclic adenosine monophosphate (cAMP) content ([cAMP]i), and vaginal lubrication were investigated using short-circuit current (ISC) of rat vaginas incubated in vitro, enzyme-linked immunosorbent assay (ELISA), and measurement of vaginal lubrication in vivo, respectively. The expressions of β-AR in vaginal epithelium were analyzed by reverse transcription-polymerase chain reaction, western blot, and immunofluorescence.

Main Outcome Measures
Changes of ISC responses; mRNA, protein expressions and localization of β-AR; [cAMP]i; vaginal lubrication.

Results
Serosal application of adrenaline induced an increase of ISC across rat vaginal epithelium that blocked by propranolol, a β-AR antagonist, rather than phentolamine, an α-AR antagonist. β1/2-AR were both present in rat and human vaginal epithelial cells. Removing Cl− or application of CFTR(inh)-172, an inhibitor of cystic fibrosis transmembrane conductance regulator (CFTR), abolished adrenaline-induced ISC responses. The elevated levels of [cAMP]i induced by adrenaline were prevented by the pretreatment with propranolol. Vaginal lubrication measured in vivo showed that adrenaline or pelvic nerve stimulation caused a marked increase in vaginal lubrication, whereas pretreatment with propranolol or CFTR(inh)-172 reduced the effect.

Conclusions
Activation of epithelial β-AR facilitates vaginal lubrication during sexual arousal by stimulating vaginal epithelial Cl− secretion in a cAMP-dependent pathway. Thus, vaginal epithelial β-AR might be another regulator of vaginal sexual arousal responses.
Erection Hardness Score for the Evaluation of Erectile Dysfunction: Further Psychometric Assessment in Patients Treated by Intracavernous Prostaglandins Injections after Radical Prostatectomy
Authors: Parisot Juliette , Yiou René , Salomon Laurent , de la Taille Alexandre , Lingombet Odile , Audureau Etienne 
Published: May 2014

AbstractIntroductionErectile dysfunction (ED) affects quality of life in patients treated by radical prostatectomy (RP). The Erection Hardness Score (EHS) is a single-item scale that has demonstrated good psychometric properties for assessing erectile function (EF) in patients treated by sildenafil, but its applicability to other treatment contexts has not yet been tested.AimThis study aims to test the validity and time and treatment responsiveness of the EHS to assess ED in men with post-RP ED treated with alprostadil injections.MethodsThis is a 1-year follow-up cohort study of 75 patients treated by RP for localized prostate cancer in a urology department setting between January 2007 and December 2008. Data were prospectively collected at 6 and 12 months post-RP.Main Outcome MeasuresThe EHS, the International Index of Erectile Function (IIEF) reference questionnaire, the Global Assessment Questionnaire (GAQ), and Numeric Pain Scale (NPS) were collected. Convergent validity (Spearman correlation coefficients with IIEF domains), known-groups validity (comparing EHS scores across ED severity groups), time and treatment responsiveness (effect size with/without treatment and over the follow-up period), and predictive ability (area under the receiver operating characteristics curve [AUC-ROC]) were analyzed for this study.ResultsThe EHS showed good convergent validity (all Spearman coefficients significant at the P &lt; 0.05 level), adequate known-groups validity (global differentiation between IIEF-EF severity groups; P &lt; 0.001), and treatment responsiveness (effect size: +1.8 [6 months], +2.1 [12 months]), but limited time responsiveness and predictive ability of the EHS for a normal EF at 12 months follow-up when compared with the IIEF-EF domain (AUC-ROC: 0.72 vs. 0.85; P &lt; 0.01).ConclusionOur findings support the overall good psychometric properties of the EHS in patients with post-RP ED treated with alprostadil injections. However, evidence for limited predictive validity and responsiveness to change over time should be considered for its use in clinical follow-up in this population.
A FAST FRACTIONAL DIFFERENCE ALGORITHM
Authors: Jensen Andreas Noack , Nielsen Morten Ørregaard 
Published: May 2014

AbstractWe provide a fast algorithm for calculating the fractional difference of a time series. In standard implementations, the calculation speed (number of arithmetic operations) is of order T2, where T is the length of the time series. Our algorithm allows calculation speed of order TlogT. For moderate and large sample sizes, the difference in computation time is substantial. Copyright © 2014 John Wiley & Sons, Ltd.
Infiltrating neutrophils aggravate metabolic liver failure in fah‐deficient mice
Authors: Qi Ziping , Wang Xin , Wei Haiming , Sun Rui , Tian Zhigang 
Published: May 2014

AbstractBackground & AimsMice deficient in tyrosine catabolic enzyme fumarylacetoacetate hydrolase (fah−/−) was a useful animal model for studying liver failure. Tyrosine metabolic toxicants accumulate in hepatocytes over time in fah−/− mice, leading to hepatocyte necrosis which we propose release many type of damage associated molecular patterns (DAMPs) and cause chronic inflammation. However, whether immune‐mediated inflammations cause a second wave of liver damage in fah−/− mice have never been investigated.MethodsThe progressive changes in body weight, survival rate and liver inflammation were examined after the protective drug (NTBC) withdrawal. Cell depletion and receptor blocking were used to define the key immune cells and molecules in liver injury.ResultsAfter removing of NTBC, fah−/− mice lost their body weight gradually, and finally died when the body weight largely reduced (low to 70%), along with increased serum ALT and total bilirubin. Importantly, a large amount of liver‐infiltrating neutrophils were observed. Neutrophils depletion reduced the liver failure, and resulted in a better survival of fah−/− mice after NTBC withdrawal. The liver tissues produce more CCR2 chemokine, with neutrophils expressing more CCR2. CCR2 inhibition reduced the number of liver‐infiltrating neutrophils and increased the expression of repair cytokine IL‐22, with a longer survival of fah−/− mice after NTBC withdrawal.ConclusionsThe excess infiltrating neutrophils exacerbate liver failure in fah−/− mice which can be attenuated by blocking CCR2.
VALUATION OF BARRIER OPTIONS VIA A GENERAL SELF‐DUALITY
Authors: Alòs Elisa , Chen Zhanyu , Rheinländer Thorsten 
Published: May 2014

AbstractClassical put–call symmetry relates the price of puts and calls under a suitable dual market transform. One well‐known application is the semistatic hedging of path‐dependent barrier options with European options. This, however, in its classical form requires the price process to observe rather stringent and unrealistic symmetry properties. In this paper, we develop a general self‐duality theorem to develop valuation schemes for barrier options in stochastic volatility models with correlation.
ARROW–DEBREU EQUILIBRIA FOR RANK‐DEPENDENT UTILITIES
Authors: Xia Jianming , Zhou Xun Yu 
Published: May 2014

AbstractWe provide conditions on a one‐period‐two‐date pure exchange economy with rank‐dependent utility agents under which Arrow–Debreu equilibria exist. When such an equilibrium exists, we show that the state‐price density is a weighted marginal rate of intertemporal substitution of a representative agent, where the weight depends on the differential of the probability weighting function. Based on the result, we find that asset prices depend upon agents' subjective beliefs regarding overall consumption growth, and we offer a direction for possible resolution of the equity premium puzzle.
Using molecular prey detection to quantify rock lobster predation on barrens‐forming sea urchins
Authors: Redd K. S. , Ling S. D. , Frusher S. D. , Jarman S. , Johnson C. R. 
Published: May 2014

AbstractWe apply qPCR molecular techniques to detect in situ rates of consumption of sea urchins (Centrostephanus rodgersii and Heliocidaris erythrogramma) by rock lobsters (Jasus edwardsii). A non‐lethal method was used to source faecal samples from trap‐caught lobsters over 2 years within two no‐take research reserves. There was high variability in the proportion of lobsters with faeces positive for sea urchin DNA across years and seasons dependent on lobster size. Independent estimates of lobster predation rate on sea urchins (determined from observed declines in urchin abundances in the reserves relative to control sites) suggest that rates of molecular prey detection generally overestimated predation rates. Also, small lobsters known to be incapable of directly predating emergent sea urchins showed relatively high rates of positive tests. These results indicate that some lobsters ingest non‐predatory sources of sea urchin DNA, which may include (i) ingestion of C. rodgersii DNA from the benthos (urchin DNA is detectable in sediments and some lobsters yield urchin DNA in faeces when fed urchin faeces or sediment); (ii) scavenging; and/or predation by rock lobsters on small pre‐emergent urchins that live cryptically within the reef matrix (although this possibility could not be assessed). While the DNA‐based approach and direct monitoring of urchin populations both indicate high predation rates of large lobsters on emergent urchins, the study shows that in some cases absolute predation rates and inferences of predator–prey interactions cannot be reliably estimated from molecular signals obtained from the faeces of benthic predators. At a broad semi‐quantitative level, the approach is useful to identify relative magnitudes of predation and temporal and spatial variability in predation.
Graft rupture after high‐dose intravenous immunoglobulin therapy in a renal transplant patient
Authors: Sin Yong‐Hun , Kim Yong‐Jin , Oh Joon Seok , Lee Jin Ho , Kim Seong Min , Kim Joong Kyung 
Published: May 2014

AbstractCases of life‐threatening thromboses in pulmonary, coronary, cerebral and peripheral vessels are associated with high‐dose intravenous immunoglobulin (IVIg) therapy that is generally considered safe. We experienced a patient with a renal graft rupture that developed after high‐dose IVIg was administered for desensitization. A needle biopsy performed 4 days prior to the rupture revealed the presence of glomerular thrombosis and mesangiolysis. The ruptured nephrectomy specimen contained renal infarction around the haemorrhagic segment and arterial wall thickening with intimal fibrosis. This might have contributed to rupturing associated with small arterial and glomerular arteriolar thrombi. This is the first case of a graft rupture as a complication of high‐dose IVIg we have encountered.
Successful treatment of BK virus nephropathy using therapeutic drug monitoring of mycophenolic acid
Authors: Kobayashi Akimitsu , Yamamoto Izumi , Nakada Yasuyuki , Kidoguchi Satoshi , Matsuo Nanae , Tanno Yudo , Ohkido Ichiro , Tsuboi Nobuo , Yamamoto Hiroyasu , Yokoyama Keitaro , Yokoo Takashi 
Published: May 2014

AbstractWe report the successful management of BK virus nephropathy (BKVN) using therapeutic drug monitoring (TDM) of mycophenolic acid (MPA). A 40‐year‐old woman was admitted for a protocol biopsy 3 months following primary kidney transplantation. Histological features were distributed in mainly two sections: the corticomedullary junction and cortical area. In the former, massive interstitial mononuclear cell infiltration and mild to moderate tubulitis with nuclear inclusion bodies were found. SV40 staining was positive in the injured tubules. These findings were compatible with BKVN. In the latter, focal interstitial inflammation and severe tubulitis without cytopathic changes were identified outside of SV40‐positive areas. Based on the histological findings, we diagnosed BKVN and we also suspected of the complication with acute T‐cell‐mediated rejection. We started steroid pulse therapy and reduced the dosage of immunosuppressive therapy under careful monitoring, using not only a trough level of tacrolimus but also a 12‐h area under the curve (AUC0–12) of MPA. After the treatment, the patient maintained kidney function. This case report demonstrates the usefulness of MPA AUC0–12 for more accurate adjustment of immunosuppressive therapy and the difficulty of pathological differentiation of BKVN and acute cellular rejection.
A case of IgG4‐positive plasma cell‐rich tubulointerstitial nephritis in a kidney allograft mimicking IgG4‐related kidney disease
Authors: Nishikawa Kouhei , Takeda Asami , Masui Satoru , Kanda Hideki , Yamada Yasushi , Arima Kiminobu , Morozumi Kunio , Sugimura Yoshiki 
Published: May 2014

AbstractA 51‐year‐old woman received an ABO blood type‐incompatible renal transplant. She was administered rituximab and basiliximab and underwent plasma exchanges for induction therapy, followed by administration of tacrolimus, mycophenolate mofetil and methylprednisolone as maintenance immunosupression therapy. A planned renal biopsy 2 years after transplantation revealed infiltration of plasma cells in the renal interstitium, although there was no ‘storiform’ fibrosis surrounding these cells. There were also no findings of rejection, BK virus nephropathy, or atypical plasma cells. Immunohistochemical stainings showed a large number of IgG4‐positive plasma cells, most of which expressed kappa‐type light chains. A CT scan showed a mass at the renal hilum. The serum IgG4 level was high. Based on these findings, the patient was suspected of having IgG4‐related kidney disease. Nine months after the biopsy, her serum creatinine level increase to 1.56 mg/dL and the dose of methylprednisolone was therefore increased to 16 mg/day. Three months after this increase in steroid, a CT scan showed the hilum mass had disappeared. A follow‐up biopsy 5 months later showed that infiltration of plasma cells in the renal interstitium had decreased markedly, although focal and segmental severely fibrotic lesions with IgG4‐positive plasma cells were observed. Serum IgG4 levels decreased immediately after the increase in steroid dose and remained <100 mg/dL despite a reduction in methylprednisolone to 6 mg/day. Serum creatinine levels also remained stable at around 1.6 mg/dL. To our knowledge, this is the first report of IgG4‐positive plasma cell‐rich tubulointerstitial nephritis mimicking IgG4‐related kidney disease after kidney transplantation.
Nitric oxide production and blood pressure reduction during haemodialysis
Authors: Chang Chiz‐Tzung , Chien Ming‐Hui , Yang Kai‐Liang , Yu Chien‐Chih , Hsu Jing‐Fang , Wang I‐Kuan , Lim Paik‐Seong , Huang Chiu‐Ching 
Published: May 2014

AbstractAimA decrease of systolic blood pressure in excess of 20 mmHg during haemodialysis treatment (IDD) is common for haemodialysis patients. Intradialytic hypotension (IDH) is symptomatic IDD by definition. Overproduction of nitric oxide (NO) is a possible cause of IDD. Dialysate nitrate and nitrite amount can be used as an indicator of intradialysis NO production. Our aim was to find the predictor of NO production in IDD patients.MethodsPartial dialysate samples were collected during the whole haemodialysis session and total dialysate nitrate and nitrite amount was measured to assess the association of intradialysis NO production with blood pressure change.ResultsThere were 31 IDD patients and 71 patients who did not develop IDD (NIDD) included in the study. Among the IDD patients, 13 were IDH patients with a mean systolic blood pressure lower than that of the other 18 symptomless IDD patients (96.6 ± 3.4 mmHg vs 125.0 ± 3.8 mmHg, P < 0.001). The median value of NO production was higher in the IDD than in the NIDD patients (447.7 μg vs 238.8 μg, P < 0.001). The NO production correlated linearly with blood pressure reduction (R = 0.487, P < 0.001). The multivariate analysis showed that NO production was positively associated with predialysis systolic blood pressure.ConclusionNitric oxide production during haemodialysis was higher in IDD than in NIDD patients. IDH often occurred when systolic blood pressure was reduced to below 100 mmHg. The amount of NO produced during haemodialysis, which may be associated with predialysis systolic blood pressure, can be used to predict intradialysis blood pressure decrease.
Peripheral odontogenic myxoma presenting as a gingival mass – a unique presentation with calcification
Authors: Jose M. , Basheer S. , Balan A. , Shameena P.M. 
Published: May 2014

AbstractMyxomas of the jaws are considered to arise from odontogenic ectomesenchyme. They bear a close resemblance to the mesenchymal portion of a developing tooth. Peripheral odontogenic myxomas are very rare and less aggressive compared with the central odontogenic myxomas. No case of peripheral odontogenic myxoma with calcification has been reported to date. The purpose of this article is to document a case of peripheral odontogenic myxoma with calcification, located on the posterior maxillary gingiva.