bluuebunny/crossref_metadata_2025_split huggingface dataset:
La terre et ses manufacturiers. L’introduction d’une raison gestionnaire dans les domaines agricoles (1800-1850)
Authors: Depecker Thomas , Joly Nathalie 
Published: October 2015

Idéal caractéristique du xix e siècle, l’éthos productiviste et son déploiement au sein de l’univers industriel ont donné lieu à une littérature très fournie, s’attachant aux techniques d’usage des corps au travail et aux disciplines propres à la « grande entreprise fermée ». Mais force est de constater que le domaine agricole est rarement pris comme objet d’étude par les historiens du travail et de la gestion. Pourtant, à l’orée du capitalisme agraire, des agents du « progrès agricole » sont eux aussi convaincus, voire fascinés, par la perspective d’optimiser l’usage des forces de travail animale et humaine au sein des grands domaines. Dans la lignée des ingénieurs du xviii e siècle, ils développent des méthodologies d’approche de l’exploitation des terres, des hommes et des animaux avec un enthousiasme et une rigueur qui n’ont rien à envier aux réalisations menées plus systématiquement dans le secteur industriel et qui même possèdent leurs spécificités. Cet article entend contribuer à l’analyse des mouvements de réforme de la quantification et de l’emploi du chiffre dans les exploitations agricoles au premier xix e siècle.
Quelques aspects inexplorés de l’histoire managériale des chemins de fer en France : les méthodes de calcul du prix de revient (1842-1883)
Authors: Dakkam Mohamed Ali 
Published: October 2015

Cette étude porte sur les pratiques managériales des compagnies ferroviaires en matière de calcul de coûts. L’analyse de la littérature comptable d’une part et des comptabilités réelles des compagnies d’autre part fait ressortir un certain décalage entre deux types de savoirs : des savoirs théoriques très avancés développés dans les écrits des ingénieurs et des savoirs pratiques qui sont loin de refléter cette richesse théorique. Cet écart entre théories et pratiques s’explique par les spécificités des compagnies ferroviaires comme grandes entreprises de réseau chargées d’un service public mais également par des conflits entre différentes parties prenantes qui cherchent à s’approprier l’information comptable et à légitimer leur pouvoir en matière de gestion ferroviaire.
Gérer l’erreur : le quotidien décisionnel d’un institut de sondages
Authors: Lamendour Eve 
Published: October 2015

Centrée sur une entreprise de sondages figurant parmi les leaders français en matière d’études politiques, publicitaires et marketing, cette recherche est fondée sur une séquence d’observations participantes réalisées entre 1989 et 1991. En réinterrogeant ce terrain ancien, apparaît un quotidien des chargés d’études, des responsables et des directeurs intermédiaires qui s’apparente à un grand écart : produire des études reconnues qui font l’image de l’entreprise d’une part et gérer au quotidien le lot important d’erreurs figurant dans ces études d’autre part.
Comparative analysis of the immunohistochemical expression of vascular endothelial growth factor and matrix metalloproteinase-9 in keratocystic odontogenic tumor, dentigerous cyst and radicular cyst
Authors: Khot Komal , Deshmukh Siddharth B. , Alex Sheeba 
Published: October 2015

Background:
Vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) have been implicated in the pathogenesis of cysts. Both these factors seem to be interrelated to each other. The importance of the MMPs in the induction of the angiogenic process has recently been described. MMPs, which are produced by microvascular endothelial cells, break down the extracellular matrix. This is one of the earliest and sustained events in the process of new capillary formation. Thus, we studied the expression of VEGF and MMP-9 in Keratocystic odontogenic tumors (KCOTs), dentigerous cysts (DCs) and radicular cysts (RCs).

Materials and Methods:
Ten cases each of KCOTs, DCs and RCs and were included in the study and immunohistochemistry was performed using anti-VEGF and anti-MMP-9 antibody using standard protocol.

Result:
When the data of positive cells in the epithelium of KCOTs was compared with DCs and RCs, it showed highly significant results (P < 0.05). Furthermore, the expression of VEGF and MMP-9 in the stroma of KCOTs showed a significant result when compared to DCs and RCs. The expression of VEGF in inflammatory cells was more in RCs when compared to DCs. Also, the expression of MMP-9 was more in RCs and DCs as compared to KCOTs.

Conclusion:
Higher expression of VEGF and MMP-9 in KCOTs could be responsible for the aggressive behavior of this cyst that is currently considered a cystic tumor rather than a developmental cyst.
The role of the vascular endothelial growth factor/vascular endothelial growth factor receptors axis mediated angiogenesis in curcumin-loaded nanostructured lipid carriers induced human HepG2 cells apoptosis
Authors: Wang Fengling , He Zhengmin , Dai Wenting , Li Qi , Liu Xiuzhen , Zhang Zhengsheng , Zhai Dandan , Chen Jin , Chen Weidong 
Published: October 2015

Background:
Curcumin (diferuloylmethane), the active constituent of turmeric extract has potent anti-cancer properties have been demonstrated in hepatocellular carcinoma (HCC). However, its underlying molecular mechanism of therapeutic effects remains unclear. Vascular endothelial growth factor (VEGF) and its receptors (VEGFRs) have crucial roles in tumor angiogenesis.

Purpose:
The goal of this study was to investigate the role of the VEGF/VEGFRs mediated angiogenesis during the proliferation and apoptosis of human HepG2 hepatoma cell line and the effect of curcumin-loaded nanostructured lipid carriers (Cur-NLC).

Materials and Methods:
The proliferation of HepG2 cells was determined by methyl thiazolyl tetrazolium after exposure to Cur-NLC and native curcumin. Apoptosis was quantified by flow cytometry with annexin V-fluorescein isothiocyanate and propidium iodide staining. Cellular internalization of Cur-NLC was observed by fluorescent microscope. The level of VEGF was detected by enzyme-linked immunosorbent assay kits. The expression of VEGFRs was quantified by Western blotting.

Results:
Cur-NLC was more effective in inhibiting the proliferation and enhancing the apoptosis of HepG2 cells than native curcumin. Fluorescent microscope analysis showed that HepG2 cells internalized Cur-NLC more effectively than native curcumin. Furthermore, Cur-NLC down-regulated the level of VEGF and the expression of VEGFR-2, but had a slight effect on VEGFR-1.

Conclusion:
These results clearly demonstrated that Cur-NLC was more effective in anti-cancer activity than the free form of curcumin. These studies demonstrate for the 1st time that Cur-NLC exerts an antitumor effect on HepG2 cells by modulating VEGF/VEGFRs signaling pathway.
Clinical impact of postprogression survival for overall survival in elderly patients (aged 75 years or older) with advanced nonsmall cell lung cancer
Authors: Yoshino Reiko , Imai Hisao , Mori Keita , Tomizawa Yoshio , Takei Kosuke , Tomizawa Mai , Kaira Kyoichi , Yoshii Akihiro , Watanabe Satoru , Saito Ryusei , Yamada Masanobu 
Published: October 2015

Introduction:
The effects of first-line single-agent chemotherapy on overall survival (OS) might be confounded by subsequent treatments in elderly patients with nonsmall cell lung cancer (NSCLC). We, therefore, aimed to evaluate whether progression-free survival (PFS), postprogression survival (PPS), or tumor response might be a valid surrogate endpoint for OS in this patient population.

Patients and Methods:
We retrospectively reviewed the clinical data of 58 elderly patients with advanced NSCLC, who received first-line single-agent cytotoxic chemotherapy at our institution between October 2003 and November 2013. The relationships of PFS, PPS, and tumor response with OS were individually analyzed.

Results:
The study cohort included 46 men and 12 women with a median age of 79 years (range: 75-87 years). There were 30 adenocarcinomas, 22 squamous cell carcinomas, and 6 other histologic types with 1 stage IIIA, 9 IIIB, and 48 IV cases. The performance status (PS) scores were 0, 1, and 2 in 18, 35, and 5 patients, respectively. The median PFS and OS were 2.8 and 5.4 months, respectively. Our analyses revealed a strong correlation of PPS and PFS with OS, whereas that between tumor shrinkage and OS was weak. Tumor stage and PS after initial treatment were significantly associated with PPS. Individual analysis indicated that PPS might serve as a surrogate for OS in elderly patients with advanced NSCLC receiving first-line single-agent chemotherapy.

Conclusion:
Our findings suggested that the disease course after progression following first-line single-agent chemotherapy might influence the OS of elderly patients with advanced NSCLC.
Enhancing the longevity of three-dimensional dose in a diffusion-controlled Fricke gel dosimeter
Authors: Babu S. Ebenezer Suman , Singh I. Rabi Raja , Poornima C. G. , Ravindran B. Paul 
Published: October 2015

Introduction:
The principle of Fricke gel dosimeter is the oxidation of ferric ions on exposure to radiation. The major limitation in this dosimeter is the post-irradiation diffusion of ferric ions leading to degradation of spatial dose information.

Aims and Objectives:
The primary objective of this study is to reduce diffusion of ferric ions post-irradiation and enhance the spatial stability of the dose for an acceptable period, within which it can be read out.

Materials and Methods:
A novel method has been proposed to achieve this aim by incorporation of an anti-oxidant in the present Fricke gel dosimeter. The modified gel prepared in this study consisted of 50 mM sulfuric acid, 0.05 mM xylenol orange, 0.5 mM ferrous ammonium sulfate, and an optimal concentration of anti-oxidant. Different concentrations of the anti-oxidant (ascorbic acid and glycine) based gel dosimeters were prepared. The performance evaluations of the same were characterized dosimetrically with high energy photons (x- and gamma rays). Spectrophotometric measurements of gel dosimeters were performed at a wavelength of 585 nm and the post-irradiation diffusion was studied by observing the dose response over time. The spatial dose information from the large volume cylindrical gel phantoms was acquired using an in-house optical computed tomography scanner.

Results:
Auto-oxidation and diffusion were controlled in the enhanced Fricke gel dosimeter by the incorporation of glycine as anti-oxidant. The post-irradiation dose in the gel dosimeter was stable up to 6 hours, thereby enhancing the longevity of three-dimensional (3D) dose.

Conclusion:
The widely established limitations of Fricke gel dosimeter viz., auto-oxidation and diffusion were overcome using a novel method that incorporated optimal quantity of glycine as a suitable anti-oxidant. This modified Fricke gel dosimeter could be used as an effective 3D dosimeter for practical applications in radiotherapy.
Study of distribution of inguinal nodes around the femoral vessels and contouring of inguinal nodes
Authors: Rao Arpitha S. , Rajmanickam Karthick , Narayanan Geeta S. 
Published: October 2015

Aims:
To determine the distribution of inguinal nodes around the vessels, margins needed around the vessels and inferior extent of contouring in the inguinal region.

Subjects and Methods:
Fifty patients having pelvic malignancies with one or more malignant nodes in the inguinal region were retrospectively included in this study. The position of the nodes in relation to the vessels, size of the nodes, the distance from the center of the node to the edge of the nearest vessel was measured. Margins required to cover the nodes from the vessels and position of the nodes in relation to the lesser trochanter was noted.

Results:
Most of the nodes were placed either anteromedial (46%) or anterior (46.6%) to the vessels (92.6%). The range of margin required to cover all nodes in the anteromedial, anterior and anteriolateral direction varied from 0.8 to 2.7 cm. Only one node was more than 2 cm below the lower edge of lesser trochanter.

Conclusion:
Elective clinical target volume for inguinal lymph nodes requires a minimum margin of 2.5 cm from the femoral vessels in the anterior, anterolateral and anteromedial direction 1.5 cm margin is required medially. Inferior extent of the contour should be 2 cm below the lower edge of lesser trochanter.
Estimation des précipitations par télédétection au Mato Grosso (Brésil)
Authors: Dubreuil V. , Jallet A. , Ronchail J. , Maitelli G. 
Published: October 2015

Dans les régions des fronts pionniers du centre du Mato Grosso, les rendements des cultures implantées par les colons depuis une vingtaine d’années (soja, canne à sucre, coton, maïs) sont encore largement tributaires de la variabilité pluviométrique interannuelle; cependant l’estimation à échelle fine des précipitations est impossible étant donné les lacunes du réseau d’observation au sol. Nous avons choisi d’utiliser les données infrarouge GOES-8 à pleine résolution (4km) pour essayer de répondre à cette question. Un premier jeu de données a été constitué en retenant pour chaque mois la valeur maximale de la température observée pour chaque pixel afin de ne conserver que l’émission en provenance du sol dont l’intensité est surtout fonction de la quantité de pluie reçue. Un second jeu de données a été constitué en seuillant les mêmes images à partir de –40°C : ainsi, l’occurrence des nuages à sommet froid pluviogènes peut être également suivie au pas de temps mensuel. Les résultats calculés sur la période de septembre 1999 à août 2000 montrent que les pluies mesurées au sol sont mieux corrélées aux occurrences (r = 0.86) qu’avec les températures maximales (r = - 0.65). Les bons résultats obtenus aux pas de temps mensuels et annuels permettent de réaliser une cartographie des précipitations par satellite qui fait clairement ressortir l’influence de la topographie.
La saison pluvieuse au proche-orient : une tendance au raccourcissement
Authors: Traboulsi Myriam 
Published: October 2015

Les précipitations proche-orientales sont caractérisées par une grande variabilité interannuelle, particulièrement au début et à la fin de la saison pluvieuse, lorsque se produisent les précipitations les plus utiles pour la vie végétative. Cette contribution propose de déterminer des dates de démarrage et de fin de la saison pluvieuse pour la période allant de septembre 1970 à juin 2002 en appliquant une Analyse en Composantes Principales sur les données quotidiennes de 20 stations réparties sur le Liban, la Syrie, la Jordanie et Israël. Les valeurs minimales et maximales des scores cumulés de la première composante (42,2 % de la variance), calculées année par année, ont permis de déterminer des dates de début et de fin de la saison pluvieuse. Les séries temporelles montrent une tendance au raccourcissement de cette saison qui est plus liée à une fin précoce qu’à un démarrage tardif. Ce raccourcissement est associé à une tendance à la hausse du géopotentiel 500 hPa, durant la saison printanière, au-dessus de la zone étudiée.
Laser-Assisted Cataract Surgery: Soft Lens Assisted Interface (SoftFit) versus Direct Contact Interface
Authors: Asena Bilgehan Sezgin , Kaskaloglu Mahmut 
Published: October 2015

Purpose To determine the safety of the Laser SoftFit™ patient interface by comparing intraoperative results with the contact interface of the LenSx® femtosecond laser platform (FSL). Methods In this nonrandomized, consecutive case series, 50 eyes underwent femtosecond laser-assisted cataract surgery (FLACS) using the LenSx® laser platform (group 1); FLACS was performed in another 50 eyes, using the Laser SoftFit™ patient interface (group 2). Intraoperative complications (corneal folds) and surgical results (incomplete and free capsulotomies, incomplete phacofragmentation, and unopened incisions) were compared. Results Corneal folds and incomplete capsulotomies were less common (p = 0.0001 for both) and free-floating capsulotomies were more frequent (p = 0.0001) with the Laser SoftFit™ patient interface. Incomplete phacofragmentation and unopened incision exhibited similar rates in both groups (p = 0.436 and 0.204, respectively). Conclusions Using the Laser SoftFit™ patient interface decreased the incidence of corneal folds, resulting in better capsulotomy outcomes during FLACS.
Tendon Elongation with Bovine Pericardium (Tutopatch®) When Conventional Strabismus Surgery is Not Possible
Authors: van Rijn Laurentius J. , van De Ven Stephanie J.N. , Krijnen Jacqueline S.M. , Jansen Suzanne M. , Bakels Amber J. , Langenhorst Anne-Marie E.L. 
Published: October 2015

Purpose Sometimes, a conventional recess-resect surgery may not be sufficient to obtain satisfactory ocular alignment. Patients who have previously undergone surgery and/or have a large difference in visual acuity between both eyes and do not wish to undergo surgery on the sound eye provide a surgical challenge. In these cases, tendon elongation with bovine pericardium may be an option. Methods We retrospectively reviewed the charts of 38 patients who underwent strabismus surgery with tendon elongation. Before surgery, 31 had exotropia (angle −21.8 ± 5.7 degrees) and 7 esotropia (angle +19.1 ± 5.4 degrees). Reasons for tendon elongation included the following: 15 patients refused surgery on their sound eye; in 15 patients, conventional recess-resect was not possible; and in 7 patients, the elongation best fitted the motility pattern. In one patient, tendon elongation was preferred over conventional recession because of a thin sclera. Follow-up was 0.5 to 4 years. Results At last follow-up visit, in patients with previous exotropia, the angle was −3.3 ± 5.9 degrees; in patients with previous esotropia, +0.2 ± 0.5 degrees. Most had some duction limitation in the direction of the elongated muscle. All patients but one were satisfied with the result. In the patients with previous exotropia, there was a small but nonsignificant regression to recurrence of the exodeviation (on average 0.5 degree per year). Conclusions Tendon elongation is a valuable addition to our strabismus surgery repertoire. However, because of duction limitations after surgery, it should be reserved for those cases in which conventional surgery is not an option.
Arthroscopic Labral Repair versus Labral Debridement in Patients with Femoroacetabular Impingement: A Minimum 2.5 Year Follow-up Study
Authors: Cetinkaya Sarper , Toker Berkin , Ozden Vahit E. , Dikmen Goksel , Taser Omer 
Published: October 2015

Purpose To compare the clinical results of labral repair with labral debridement in patients undergoing arthroscopy for femoroacetabular impingement. Methods Between July 2008 and December 2011, 67 patients (73 hips) underwent arthroscopic treatment for femoroacetabular impingement. The repair group consisted of 33 patients; 18 hips with pincer only, 1 with CAM only and 15 with combined impingement. The debridement group contained 34 patients; 6 with pincer only, 5 with CAM only and 28 with combined type. The mean age in the repair group was 33.5 years (range, 30-61) and in the debridement group was 39.5 years (range, 18-59 y). At the time of last follow-up, patient's hip function was evaluated with ROM of the hip; daily Hip Outcome scores (dHOS) and Visual Analogue Score (VAS). Results The mean follow-up was 45.2 month in the repair group and 47.2 month in debridement group. Daily hip outcome scores were significantly improved from preoperatively to last follow-up in both groups (p<0.05). However, there were no statistical significant difference in dHOS between repair and debridement groups (p>0.05) at last follow-up. 2 patients in the repair group and 1 patient in the debridement group had undergone total hip replacement at an average of 16 months (range, 4-32 m) after arthroscopic treatment. Hip joint instability occurred in 1 patient in the repair group due to aggressive capsular resection. This was treated by a periacetabular osteotomy. Conclusions No difference in hip functional outcomes was observed between labral debridement and labral repair in arthroscopic treatment of femoroacetabular impingement.
Bioavailability of Gentamicin and Vancomycin Released from an Antibiotic Containing Bone Cement in Patients Undergoing a Septic One-Stage Total Hip Arthroplasty (THA) Revision: A Monocentric Open Clinical Trial
Authors: Kendoff Daniel O. , Gehrke Thorsten , Stangenberg Peter , Frommelt Lars , Bösebeck Hans 
Published: October 2015

Background The purpose of this clinical investigation was to evaluate the systemic bioavailability of antibiotics from bone cement after implantation. This was done by determining the concentrations of gentamicin and vancomycin in plasma and urine of patients receiving a novel bone cement during one-stage revision in periprosthetic hip infections. The local concentrations of both antibiotic agents in wound exudate as well as the efficacy and tolerability were assessed as a secondary objective. Methods In a prospective open clinical trial, 20 patients (mean age 62.5 years) with an implanted hip prosthesis requiring revision due to periprosthetic infection were treated with this antibiotic loaded bone cement (ALBC) between 2009 and 2011. The concentrations of gentamicin and vancomycin in plasma, urine and wound exudate were determined with quantitative liquid chromatography analysis (LC-MS-MS). Results The mean postoperative maximum gentamicin plasma concentration at 5.85 hours was 209.65 ng/mL. For vancomycin, a mean postoperative maximum plasma concentration of 134.64 ng/mL was determined at 20.03 hours. Small amounts of both antibiotics were excreted via the urine within the first 10 days after surgery. No reinfection was observed at the end of the hospital stay or during the follow-up period up to 7 months post surgery. Conclusions Slow absorption of both antibiotics after release from the cement resulted in plasma concentrations well below toxic levels and did not result in a critical systemic concentration potientially inducing bacterial resistance. The treatment with this novel bone cement was assessed as efficacious and was very well tolerated by all patients.
Oxygen Measurement in Interstitially Perfused Cellularized Constructs Cultured in a Miniaturized Bioreactor
Authors: Raimondi Manuela T. , Giordano Carmen , Pietrabissa Riccardo 
Published: October 2015

Aims The possibility of developing engineered tissue in vitro and maintaining the cell viability and functionality is primarily related to the possibility of controlling key culture parameters such as oxygen concentration and cell-specific oxygen consumption. We measured these parameters in a three-dimensional (3D) cellularized construct maintained under interstitially perfused culture in a miniaturized bioreactor. Methods MG63 osteosarcoma cells were seeded at high density on a 3D polystyrene scaffold. The 3D scaffolds were sensorized with sensor foils made of a polymer, which fluoresce with intensity proportional to the local oxygen tension. Images of the sensor foil in contact with the cellularized construct were acquired with a video camera every four hours for six culture days and were elaborated with analytical imaging software to obtain oxygen concentration maps. Results The data collected indicate a globally decreasing oxygen concentration profile, with a total drop of 28% after six days of culture and an average drop of 10.5% between the inlet and outlet of the perfused construct. Moreover, by importing the measured oxygen concentration data and the cell counts in a model of mass transport, we calculated the cell-specific oxygen consumption over the whole culture period. The consumption increased with oxygen availability and ranged from 0.1 to 0.7 µmol/h/106 cells. Conclusions The sensors used here allowed a non-invasive, contamination-free and non-destructive oxygen measurement over the whole culture period. This study is the basis for optimization of the culture parameters involved in oxygen supply, in order to guarantee maintenance of cell viability in our system.