bluuebunny/crossref_metadata_2025_split huggingface dataset:
Two‐year follow‐up of a randomized controlled trial of stepped care cognitive behavioral therapy to prevent recurrence of depression in an older population
Authors: Apil S. R. A. , Spinhoven P. , Haffmans P. M. J. , Hoencamp E. 
Published: July 2013

ObjectiveThis study aims to determine the long‐term effect of a stepped care cognitive behavioral therapy prevention program for depression in older people and the factors predicting or moderating outcome.MethodsIn a randomized controlled trial, 136 participants, aged 55 years or older, who had been treated for depression, received during 12 months a stepped care program (SCP) or care as usual (CAU) and were then followed up for a second year. Outcome was defined as the start of a new mental health treatment for depression in a specialized outpatient setting, as recorded in the patients' electronic medical records.ResultsOf the 123 patients, 38 required new mental health treatment. Survival analysis showed that participants in SCP (n = 27) required new treatment significantly more than patients receiving CAU (n = 11). Negative life events in the last year were predictive for new treatment in CAU but not in SCP.ConclusionsAn SCP seems to lower the threshold for new specialized mental health treatment for depression, whereas new treatment in CAU patients occurs more often in reaction to recent life events. Copyright © 2013 John Wiley & Sons, Ltd.
Promoting innovation and excellence to face the rapid diffusion of Novel Psychoactive Substances in the EU: the outcomes of the ReDNet project
Authors: Corazza Ornella , Assi Sulaf , Simonato Pierluigi , Corkery John , Bersani Francesco Saverio , Demetrovics Zsolt , Stair Jacqueline , Fergus Suzanne , Pezzolesi Cinzia , Pasinetti Manuela , Deluca Paolo , Drummond Colin , Davey Zoe , Blaszko Ursula , Moskalewicz Jacek , Mervo Barbara , Furia Lucia Di , Farre Maggi , Flesland Liv , Pisarska Agnieszka , Shapiro Harry , Siemann Holger , Skutle Arvid , Sferrazza Elias , Torrens Marta , Sambola F. , van der Kreeft Peer , Scherbaum Norbert , Schifano Fabrizio 
Published: July 2013

ObjectivesThe recent emergence of new psychoactive compounds (novel psychoactive substances (NPS)) has raised prominent challenges in the fields of drug policy, substance use research, public health and service provision. The Recreational Drugs European Network project, funded by the European Commission, was implemented to improve the information stream to young people and professionals about effects/risks of NPS by identifying online products and disseminating relevant information through technological tools.MethodsRegular multilingual qualitative assessments of websites, drugs fora and other online resources were carried out using the Google search engine in eight languages from collaborating countries. These included the following: the UK, Norway, Belgium, Germany, Hungary, Poland, Italy and Spain. Products were tested and prevention messages were developed and disseminated via technological tools such as interactive websites, SMS alert, social networking (Facebook, Twitter), Multimedia (You Tube), Smartphone applications (iPhone) and virtual learning environments (Second Life).ResultsThe Recreational Drugs European Network project established itself as the first Europe‐wide prevention programme designed for NPS based on the efficacy of novel information and communication technology‐based forms of intervention. More than 650 NPS products and combinations were identified; relevant information was disseminated to target population and advice was given to both European Union/international agencies and national policy makers.ConclusionsWeb‐monitoring activities are essential for mapping the diffusion of NPS and the use of technological tools can be successfully incorporated in specific prevention programmes. Furthermore, the involvement of multi‐disciplinary international partnerships was and continues to be fundamental for responding to such a prominent challenge. Copyright © 2013 John Wiley & Sons, Ltd.
RECK Inhibits Stemness Gene Expression and Tumorigenicity of Gastric Cancer Cells by Suppressing ADAM‐Mediated Notch1 Activation
Authors: Hong Kun‐Jing , Wu Deng‐Chyang , Cheng Kuang‐Hung , Chen Li‐Tzong , Hung Wen‐Chun 
Published: July 2013

AbstractThe Reversion‐inducing Cysteine‐rich Protein with Kazal Motifs (RECK) gene encodes a membrane‐anchored glycoprotein that exhibits strong inhibitory activity against various matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase 10 (ADAM10). RECK functions as a tumor suppressor by inhibiting migration, invasion, and angiogenesis. However, whether RECK can modulate the stem‐like phenotypes of cancer cells is not known. In this study, we demonstrate that RECK is down‐regulated in gastric cancer cells and is further reduced in CD133‐positive cancer stem‐like cells. Ectopic expression of RECK induces down‐regulation of the expression of stemness genes including Sox2, Oct4, and Nanog and the cancer stem cell marker CD133. Treatment of DAPT (a γ‐secretase inhibitor) or TAPI‐2 (a hydroxamate‐based inhibitor of MMPs, tumor necrosis factor α converting enzyme and ADAM17) reduces Notch1 shedding and activation which results in attenuation of stemness genes and CD133. Our data show that ADAM10 and ADAM17 are co‐pulled down by RECK suggesting a physical interaction between RECK and ADAMs on cell surface. In addition, RECK suppresses sphere formation and sphere size of CD133‐positive gastric cancer cells. Overexpression of Notch intracellular domain (NICD) or ADAM17 effectively reverse the inhibitory effect of RECK in CD133‐positive cells. More importantly, RECK reduces tumorigenic activity of CD133‐positive cells in vivo. Conversely, knockdown of RECK in non‐tumorigenic GI2 cells increases stemness and CD133 expression and sphere forming ability. Collectively, these results indicate that RECK represses stemness gene expression and stem‐like properties by inhibiting ADAM‐mediated Notch1 shedding and activation. J. Cell. Physiol. 229: 191–201, 2014. © 2013 Wiley Periodicals, Inc.
Crustal radial anisotropy across Eastern Tibet and the Western Yangtze Craton
Authors: Xie Jiayi , Ritzwoller Michael H. , Shen Weisen , Yang Yingjie , Zheng Yong , Zhou Longquan 
Published: July 2013

AbstractPhase velocities across eastern Tibet and surrounding regions are mapped using Rayleigh (8–65 s) and Love (8–44 s) wave ambient noise tomography based on data from more than 400 Program for Array Seismic Studies of the Continental Lithosphere and Chinese Earthquake Array stations. A Bayesian Monte Carlo inversion method is applied to generate 3‐D distributions of Vsh and Vsv in the crust and uppermost mantle from which radial anisotropy and isotropic Vs are estimated. Each distribution is summarized with a mean and standard deviation, but is also used to identify “highly probable” structural attributes, which include (1) positive midcrustal radial anisotropy (Vsh > Vsv) across eastern Tibet (spatial average = 4.8% ± 1.4%) that terminates abruptly near the border of the high plateau, (2) weaker (−1.0% ± 1.4%) negative radial anisotropy (Vsh < Vsv) in the shallow crust mostly in the Songpan‐Ganzi terrane, (3) negative midcrustal anisotropy (−2.8% ± 0.9%) in the Longmenshan region, (4) positive midcrustal radial anisotropy (5.4% ± 1.4%) beneath the Sichuan Basin, and (5) low Vs in the middle crust (3.427 ± 0.050 km/s) of eastern Tibet. Midcrustal Vs < 3.4 km/s (perhaps consistent with partial melt) is highly probable only for three distinct regions: the northern Songpan‐Ganzi, the northern Chuandian, and part of the Qiangtang terranes. Midcrustal anisotropy provides evidence for sheet silicates (micas) aligned by deformation with a shallowly dipping foliation plane beneath Tibet and the Sichuan Basin and a steeply dipping or subvertical foliation plane in the Longmenshan region. Near vertical cracks or faults are believed to cause the negative anisotropy in the shallow crust underlying Tibet.
Shear wave anisotropy beneath the volcanic front in South Kyushu area, Japan: Development of C‐type olivine CPO under H2O‐rich conditions
Authors: Terada Tadashi , Hiramatsu Yoshihiro , Mizukami Tomoyuki 
Published: July 2013

AbstractShear wave splitting from local intermediate‐depth earthquakes is investigated to detect the anisotropic structure in the mantle wedge beneath the South Kyushu area, Japan. We observed shear wave splitting with NEE‐SWW to NWW‐SEE polarization directions and delay times of 0.04–0.63 s. Trench‐normal shear wave polarization anisotropy with a delay time greater than 0.3 s probably overlaps in the high VP/VS region at a depth of 100–150 km beneath the volcanic front. Model calculations for the cause of the anisotropy suggest that the development of “C‐type” olivine crystallographic preferred orientation (CPO) with a trench‐parallel b axis concentration and a trench‐normal a axis concentration best reproduces observations compared to A‐, B‐, or E‐type olivine CPOs and antigorite CPO. We conclude that a thick anisotropic layer, approximately 50 km, is formed by concentration of interstitial fluid in peridotite. We briefly discuss the mechanism carrying water to the deep mantle wedge. A possible explanation is that interstitial fluids in the mantle wedge are effectively released because of a decrease in dihedral angles of olivine‐fluid interfaces at 150 km depth. Our results imply a close relation between the high density of explosive volcanoes in the South Kyushu area and the underlying water‐rich mantle.
High‐resolution relocation of aftershocks of the Mw 7.1 Darfield, New Zealand, earthquake and implications for fault activity
Authors: Syracuse E. M. , Thurber C. H. , Rawles C. J. , Savage M. K. , Bannister S. 
Published: July 2013

AbstractLow‐slip‐rate regions often represent under‐recognized hazards, and understanding the progression of seismicity when faults in such areas rupture will help us to better understand earthquake rupture patterns. The 3 September 2010 (UTC) Mw 7.1 Darfield earthquake revealed a formerly unrecognized set of faults in the Canterbury region of New Zealand, an area that had previously been mapped as one of the lower‐hazard areas in the country. In this study, we analyze the first four months of its aftershock sequence to identify active faults and temporal changes in seismicity along them. We jointly invert for three‐dimensional P wave and S wave velocities and hypocentral locations, using data for 2840 aftershocks recorded at 36 temporary and permanent seismic stations within 70 km of the main shock epicenter. These relocations delineate eight individual faults active prior to the 22 February 2011 Mw 6.3 Christchurch earthquake, the largest aftershock of the Darfield earthquake. Two of these faults are in the Christchurch region, one of which corresponds to geodetically determined rupture planes of the Christchurch earthquake. Using focal mechanisms calculated from first‐motion polarities, we find mainly strike‐slip faulting events, with some reverse and normal faulting events as well. We compare the orientations of these faults to the prevailing regional stress directions to identify which faults may have been active prior to the Darfield earthquake and which may be newly developed.
Is there a linkage between the tropical cyclone activity in the southern Indian Ocean and the Antarctic Oscillation?
Authors: Mao Rui , Gong Dao‐Yi , Yang Jing , Zhang Zi‐Yin , Kim Seong‐Joong , He Hao‐Zhe 
Published: July 2013

AbstractIn this article, the relationship between the Antarctic Oscillation (AAO) and the tropical cyclone (TC) activity in the southern Indian Ocean (SIO) was examined. It was found that on the interannual time scale, the AAO is well linked with the TC activity in the SIO during TC season (December–March). The rank correlation coefficient between the AAO index and the TC frequency (TCF) in the SIO is 0.37, which is significant at the 95% confidence level. When the AAO is in a positive phase, TC passage in the northwestern coast of Australia (100E°–120°E and 10°S–30°S) increases by approximately 50%–100% from the climatology. The increase in the TC passage is primarily the result of more frequent TCs originating in this region due to enhanced water vapor convergence and ascending motions, which are caused by a cyclonic height anomaly over the western coast of Australia associated with the positive AAO phases. In addition, the AAO‐height covariations, which are essential to the formation of the AAO‐TC links in the SIO, were investigated through a historical climate simulation using the Community Climate System Model 4 from the Coupled Model Intercomparison Project Phase 5. The AAO‐height links were well reproduced in the simulation. The similarity in the AAO‐height links between the observation and the simulation supports the physical robustness of the AAO‐TC links in the SIO.
A perspective on tritium versus carbon‐14: ensuring optimal label selection in pharmaceutical research and development
Authors: Krauser Joel A. 
Published: July 2013

Tritium (3H) and carbon‐14 (14C) labels applied in pharmaceutical research and development each offer their own distinctive advantages and disadvantages coupled with benefits and risks. The advantages of 3H have a higher specific activity, shorter half‐life that allows more manageable waste remediation, lower material costs, and often more direct synthetic routes. The advantages of 14C offer certain analytical benefits and less potential for label loss.Although 3H labels offer several advantages, they might be overlooked as a viable option because of the concerns about its drawbacks. A main drawback often challenged is metabolic liability. These drawbacks, in some cases, might be overstated leading to underutilization of a perfectly viable option. As a consequence, label selection may automatically default to 14C, which is a more conservative approach. To challenge this ‘14C‐by‐default’ approach, pharmaceutical agents with strategically selected 3H‐labeling positions based on non‐labeled metabolism data have been successfully implemented and evaluated for 3H loss.From in‐house results, the long term success of projects clearly would benefit from a thorough, objective, and balanced assessment regarding label selection (3H or 14C). This assessment should be based on available project information and scientific knowledge. Important considerations are project applicability (preclinical and clinical phases), synthetic feasibility, costs, and timelines.
Cultural contingencies of mediation: Effectiveness of mediator styles in intercultural disputes
Authors: Salmon Elizabeth D. , Gelfand Michele J. , Çelik Ayşe Betül , Kraus Sarit , Wilkenfeld Jonathan , Inman Molly 
Published: July 2013

SummaryThe difficulties of intercultural negotiations are well established, yet few studies have examined the factors that facilitate the successful resolution of these disputes. This research took a dynamic approach and examined the types of mediation tactics that are most effective in intercultural disputes given specific disputant characteristics. One hundred and ten participants from the United States and Turkey negotiated a community‐based dispute in real time from their respective countries using a newly developed virtual lab. Dyads were randomly assigned to negotiate with a formulative computer mediator, a manipulative computer mediator, or in an unmediated control condition. As predicted, the results showed a significant interaction between manipulative mediation and markers of disputant difficulty on Pareto efficiency. Manipulative mediation produced agreements of higher Pareto efficiency in intercultural dyads with more difficult disputants (low openness to mediation, low motivational cultural intelligence (CQ), low trust, and low willingness to concede) but lower Pareto efficiency in dyads with more favorable disputant factors (high openness to mediation, high motivational CQ, high trust, and high willingness to concede). The results for subjective value also partially supported the hypotheses. Theoretical and practical implications for the study of intercultural disputes are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Supervisors' exceedingly difficult goals and abusive supervision: The mediating effects of hindrance stress, anger, and anxiety
Authors: Mawritz Mary B. , Folger Robert , Latham Gary P. 
Published: July 2013

SummaryThis study examined a contextual predictor of abusive supervision. Specifically, we hypothesized that job goals that are judged by supervisors to be exceedingly difficult to attain is a predictor of subordinate‐rated abusive supervisory behavior. Drawing on the cognitive theory of stress, we hypothesized that exceedingly difficult job goals assigned to supervisors predict abusive behavior directed at their subordinates, as mediated by the supervisors' hindrance stress and emotions (e.g., anger and anxiety). We collected data from employees and their immediate supervisors to test this theoretical model (N = 215 matched pairs). The results of this multisource field study provided support for the hypothesized relationships. In particular, assigned job goals that were appraised by supervisors as exceedingly difficult to attain predicted their hindrance stress. Also, hindrance stress was positively related to anger and anxiety, which in turn predicted abusive supervision. Theoretically, these findings contribute to research on goal setting, stress, and abusive supervision. In addition, these findings are practically important in that they provide suggestions on how to minimize abusive supervision in organizations. Copyright © 2013 John Wiley & Sons, Ltd.
High‐resolution temperature climatology for Italy: interpolation method intercomparison
Authors: Brunetti M. , Maugeri M. , Nanni T. , Simolo C. , Spinoni J. 
Published: July 2013

ABSTRACTHigh‐resolution monthly temperature climatologies for Italy are presented. They are based on a dense and quality‐controlled observational dataset which includes 1484 stations and on three distinct approaches: multi‐linear regression with local improvements (MLRLI), an enhanced version of the model recently used for the Greater Alpine Region, regression kriging (RK), widely used in literature and, lastly, local weighted linear regression (LWLR) of temperature versus elevation, which may be considered more suitable for the complex orography characterizing the Italian territory.Dataset and methods used both to check the station records and to get the 1961–1990 normals used for the climatologies are discussed. Advantages and shortcomings of the three approaches are investigated and the results are compared.All three approaches lead to quite reasonable models of station temperature normals, with lowest errors in spring and autumn and highest errors in winter. The LWLR approach shows slightly better performances than the other two, with monthly leave‐one‐out estimated root mean square errors ranging from 0.74 °C (April and May) to 1.03 °C (December). Further evidence in its favour is the greater reliability of local approach in modelling the behaviour of the temperature‐elevation relationship in Italy's complex territory.The comparison of the different climatologies is a very effective tool to understand the robustness of each approach. Moreover, the first two methods (MLRLI and RK) turn out to be important to tune the third one (LWLR), as they help not only to understand the relationship between temperature normals and some important physiographical variables (MLRLI) but also to study the decrease of station normals covariance with distance (RK).
CXCR4 antagonism attenuates load‐induced periosteal bone formation in mice
Authors: Leucht Philipp , Temiyasathit Sara , Russell Ashley , Arguello Juan F. , Jacobs Christopher R. , Helms Jill A. , Castillo Alesha B. 
Published: July 2013

ABSTRACTMechanical loading is a key anabolic regulator of bone mass. Stromal cell‐derived factor‐1 (SDF‐1) is a stem cell homing factor that is important in hematopoiesis, angiogenesis, and fracture healing, though its involvement in skeletal mechanoadaptation is virtually unknown. The objective of this study was to characterize skeletal expression patterns of SDF‐1 and CXCR4, the receptor for SDF‐1, and to determine the role of SDF‐1 signaling in load‐induced periosteal bone formation. Sixteen‐week‐old C57BL/6 mice were treated with PBS or AMD3100, an antagonist against CXCR4, and exposed to in vivo ulnar loading (2.8 N peak‐to‐peak, 2 Hz, 120 cycles). SDF‐1 was expressed in cortical and trabecular osteocytes and marrow cells, and CXCR4 was primarily expressed in marrow cells. SDF‐1 and CXCR4 expression was enhanced in response to mechanical stimulation. The CXCR4 receptor antagonist AMD3100 significantly attenuated load‐induced bone formation and led to smaller adaptive changes in cortical geometric properties as determined by histomorphometric analysis. Our data suggest that SDF‐1/CXCR4 signaling plays a critical role in skeletal mechanoadaptation, and may represent a unique therapeutic target for prevention and treatment of age‐related and disuse bone loss. © 2013 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 31:1828–1838, 2013
The flavor of pomegranate fruit: a review
Authors: Mayuoni‐Kirshinbaum Lina , Porat Ron 
Published: July 2013

AbstractDespite the increasing commercial importance of pomegranate, especially because of its recently discovered health‐promoting benefits, relatively little is yet known regarding its sensory quality and flavor preferences, or about the biochemical constituents that determine its sensory characteristics. The perceived flavor of pomegranate fruit results from the combination of various taste, aroma and mouthfeel sensations. The taste is governed mainly by the presence of sugars (glucose and fructose) and organic acids (primarily citric and malic acids). The aroma evolves from the presence of dozens of volatiles, including alcohols, aldehydes, ketones, and terpenes, which provide a mixture of various ‘green’, ‘woody’, ‘earthy’, ‘fruity’, ‘floral’, ‘sweet’ and ‘musty’ notes. In addition, the sensory satisfaction during the eating of pomegranate arils is complemented by various mouthfeel sensations, including seed hardness and astringency sensations. In the present review we will describe the sensory quality and flavor preferences of pomegranate fruit, including the genetic diversity in flavor characteristics among distinct varieties. In addition, we will describe the dynamic changes that occur in fruit flavor during fruit ripening and postharvest storage. © 2013 Society of Chemical Industry