bluuebunny/crossref_metadata_2025_split huggingface dataset:
Chemiluminescent Afterglow Material for Enhanced Tumor Diagnosis and Photodynamic Therapy
Authors: Huang Shuai , Bai Shuaige , Luo Ting , Zheng Fan , Fan Duoyang , Zhou Yiyang , Dong Jie , Chen Fei , Zeng Wenbin 
Published: July 2024

AbstractAfterglow materials offer great advantages for imaging, including ultra‐long luminescent lifetimes for sustained signal after excitation, high signal‐to‐noise ratios due to minimal tissue autofluorescence interference, and the ability to achieve deep tissue penetration with near‐infrared (NIR) afterglow. AIEgens, known for their potent singlet oxygen (¹O₂) generation during photodynamic therapy (PDT), further enhance the approach. Here is the first report on how to integrate AIEgens with chemiluminescent agents for constructing NIR afterglow materials, enabling chemiluminescence resonance energy transfer (CRET)‐mediated activation of AIEgens for targeted PDT. DCL/TBQ nanoparticles (NPs) exemplify this promising theranostic design. These NPs exhibit high selectivity and sensitivity toward ONOO−, a biomarker associated with tumors, with a low limit of detection (46.1 nm). Additionally, DCL/TBQ NPs boast impressive deep tissue penetration (2 cm) and a remarkable 120‐fold improvement in signal‐to‐noise ratio for tumor afterglow imaging. Most importantly, significant tumor growth inhibition capabilities are demonstrated. This approach holds immense potential for the development of next‐generation theranostic agents, enabling simultaneous tumor diagnosis and treatment with improved accuracy and efficacy.
Optical Control of Adaptive Nanoscale Domain Networks
Authors: Zajac Marc , Zhou Tao , Yang Tiannan , Das Sujit , Cao Yue , Guzelturk Burak , Stoica Vladimir , Cherukara Mathew J. , Freeland John W. , Gopalan Venkatraman , Ramesh Ramamoorthy , Martin Lane W. , Chen Long‐Qing , Holt Martin V. , Hruszkewycz Stephan O. , Wen Haidan 
Published: July 2024

AbstractAdaptive networks can sense and adjust to dynamic environments to optimize their performance. Understanding their nanoscale responses to external stimuli is essential for applications in nanodevices and neuromorphic computing. However, it is challenging to image such responses on the nanoscale with crystallographic sensitivity. Here, the evolution of nanodomain networks in (PbTiO3)n/(SrTiO3)n superlattices (SLs) is directly visualized in real space as the system adapts to ultrafast repetitive optical excitations that emulate controlled neural inputs. The adaptive response allows the system to explore a wealth of metastable states that are previously inaccessible. Their reconfiguration and competition are quantitatively measured by scanning x‐ray nanodiffraction as a function of the number of applied pulses, in which crystallographic characteristics are quantitatively assessed by assorted diffraction patterns using unsupervised machine‐learning methods. The corresponding domain boundaries and their connectivity are drastically altered by light, holding promise for light‐programable nanocircuits in analogy to neuroplasticity. Phase‐field simulations elucidate that the reconfiguration of the domain networks is a result of the interplay between photocarriers and transient lattice temperature. The demonstrated optical control scheme and the uncovered nanoscopic insights open opportunities for the remote control of adaptive nanoscale domain networks.
Transwell‐Based Microfluidic Platform for High‐Resolution Imaging of Airway Tissues
Authors: Kurmashev Amanzhol , Boos Julia A. , Laventie Benoît‐Joseph , Swart A. Leoni , Sütterlin Rosmarie , Junne Tina , Jenal Urs , Hierlemann Andreas 
Published: July 2024

AbstractTranswell‐based airway models have become increasingly important in studying the effects of respiratory diseases and drug treatment at the air–liquid interface of the lung epithelial barrier. However, the underlying mechanisms at the tissue and cell level often remain unclear, as transwell inserts feature limited live‐cell imaging compatibility. Here, a novel microfluidic platform is reported for the cultivation of transwell‐based lung tissues providing the possibility to alternate between air–liquid and liquid–liquid interfaces. While the air–liquid interface recapitulates physiological conditions for the lung model, the liquid–liquid interface enables live imaging of the tissue at high spatiotemporal resolution. The plastics‐based microfluidic platform enables the insertion and recuperation of the transwell inserts, which allows for tissue cultivation and analysis under standardized well plate conditions. The device is used to monitor infections of Pseudomonas aeruginosa in human stem‐cell‐derived bronchial epithelial tissue. The progression of a P. aeruginosa infection in real‐time at high resolution is continuously imaged, which provides insights into bacterial spreading and invasion on the apical tissue surface, as well as insights into tissue breaching and destruction over time. The airway tissue culture system is a powerful tool to visualize and elucidate key processes of developing respiratory diseases and to facilitate drug testing and development.
Optical Vortices Generation via a Self‐Assembly Photonic Crystal Slab
Authors: Zhang Wenjie , Chu Jiao , Deng Ruhuan , Wang Xinhao , Li Tongyu , Liu Wenzhe , Wang Jiajun , Liu Xiaohan , Shi Lei 
Published: July 2024

AbstractOptical vortices (OVs), as common phenomena that widely exist in nature, have attracted interest both in fundamental science and applications. Recently, generating OVs by using polarization vortices in the momentum space is demonstrated. This method eliminates the need for precise optical center alignment, which relies on periodic structures. The micro‐spheres self‐assembly method is known as an inexpensive and straightforward means to fabricate periodic structures. Here, self‐assembly photonic crystal (SA‐PhC) slabs are proposed that can be used to generate OVs. With both simulations and experiments, the OVs generation via SA‐PhC slabs is investigated. The designed SA‐PhC slab is fabricated. The momentum‐space polarization vortex of the SA‐PhC slab is directly observed. The field shape and phase distribution of the generated OVs are measured. The work can broaden the applications of SA‐PhC and the generation methods of OVs.
Exciting Surface Plasmon Resonances on Gold Thin Film‐Coated Optical Fibers Through Nanoparticle Light Scattering
Authors: Mendes João P. , dos Santos Paulo S. S. , Dias Bernardo , Núñez‐Sánchez Sara , Pastoriza‐Santos I. , Pérez‐Juste Jorge , Pereira Carlos M. , Jorge Pedro A. S. , de Almeida José M. M. M. , Coelho Luís C. C. 
Published: July 2024

AbstractSurface plasmon resonance (SPR) conventionally occurs at the interface of a thin metallic film and an external dielectric medium in fiber optics through core‐guided light. However, this work introduces theoretical and experimental evidence suggesting that the SPR in optical fibers can also be induced through light scattering from Au nanoparticles (NPs) on the thin metallic film, defined as nanoparticle‐induced SPR (NPI‐SPR). This method adheres to phase‐matching conditions between SPR dispersion curves and the wave vectors of scattered light from Au NPs. Experimentally, these conditions are met on an etched optical fiber, enabling direct interaction between light and immobilized Au NPs. Compared to SPR, NPI‐SPR exhibits stronger field intensity in the external region and wavelength tuning capabilities (750 to 1250 nm) by varying Au NP diameters (20 to 90 nm). NPI‐SPR demonstrates refractive index sensitivities of 4000 to 4416 nm per refractive index unit, nearly double those of typical SPR using the same optical fiber configuration sans Au NPs. Additionally, NPI‐SPR fiber configuration has demonstrated its applicability for developing biosensors, achieving a remarkable limit of detection of 0.004 nm for thrombin protein evaluation, a twenty‐fold enhancement compared to typical SPR. These findings underscore the intrinsic advantages of NPI‐SPR for sensing.
Exploring a New Class of PVDF/3‐Aminopropyltriethoxysilane (core) and 2,2‐Bis(hydroxymethyl)butyric Acid (monomer)‐Based Hyperbranched Polyester Hybrid Fibers by Electrospinning Technique for Enhancing Triboelectric Performance
Authors: Niranjana Vadakkaveedu Subramanian , Yoon Jae Uk , Woo Insun , Gajula Prasad , Bae Jin Woo , Prabu Arun Anand 
Published: July 2024

AbstractWith the rapid advancement in sensor technologies, triboelectric nanogenerators (TENGs) have emerged as a promising sustainable power source for intelligent electronics. Herein, fabricated a novel 3‐aminopropyltriethoxysilane (core) and 2,2‐bis(hydroxymethyl)butyric acid (monomer)‐based hyperbranched polyester by facile single‐step polycondensation technique generation 2 (Si‐HBP‐G2). Further, a new class of polyvinylidene fluoride (PVDF) and different weight percentages (0, 5, 10, 15, and 20 wt%) of Si‐HBP‐G2 hybrid fiber blends are prepared by traditional electrospinning technique. The as‐prepared Si‐HBP‐G2 and its blends are well characterized using SEM/EDS, FTIR, NMR, and XRD studies. The influence of Si‐HBP‐G2 content on triboelectric performance in terms of the open circuit potential (VOC) and short circuit current (ISC) is evaluated using aluminum (Al) as a counter electrode. Among them, 15 wt% of Si‐HBP‐G2/PVDF hybrid fiber mat (PG2‐15) exhibits superior electrical performance. Which is almost increased 5.9 times (22–130 V) of VOC and 4.9 times (0.71–3.5 µA) of ISC than PVDF fiber mate. These results reveal the significance of Si‐HBP‐G2 in the triboelectric performance. The optimized TENG device (PG2‐15/Al‐TENG) exhibits a peak power density of 0.2 Wm−2 at 100 MΩ external load. Finally, the PG2‐15/Al‐TENG practically demonstrates real‐time application energy harvesting applications such as powering 100 LEDs and a stopwatch.
Volatile and Nonvolatile Dual‐Mode Switching Operations in an Ag‐Ag2S Core‐Shell Nanoparticle Atomic Switch Network
Authors: Srikimkaew Oradee , Ricci Saverio , Porzani Matteo , Dang Thien Tan , Nakaoka Yusuke , Usami Yuki , Ielmini Daniele , Tanaka Hirofumi 
Published: July 2024

AbstractThis paper proposes a nanoparticle‐based atomic switch network memristive device, capable of both volatile and nonvolatile switching operations, which have not been previously reported for this material. The operational modes can be determined by altering the compliance current, demonstrating high stability over 100 cycles. Analysis of the conduction mechanism using I–V curves reveals switching characteristics consistent with space‐charge‐limited current conduction during the set process and ohmic behavior in the reset state. Furthermore, this study analyzes these dual‐operational modes in devices with varying electrode spacings. The results indicate that a wider spacing necessitated a higher compliance current for the volatile‐to‐nonvolatile transition, underscoring the significance of interconnection. These findings facilitate the integration of neuron and synapse functions within a single atomic switch network device, thereby advancing neuromorphic systems.
Infrared Photodetector Based on van der Waals MoS2/MoTe2 Hetero‐Bilayer Modulated by Photogating
Authors: Sheng Bining , Yang Jiong , Zhang Chao , Jiang Maoxiang , Ma Wentao , Liu Xiaoyi , Kalantar‐Zadeh Kourosh , Chen Zefeng , Li Xiaofeng 
Published: July 2024

AbstractPhotodetectors based on 2D hetero‐bilayers can overcome the bandgap limitations of individual 2D monolayers and operate at relatively long wavelengths. However, ultra‐low light absorptions within hetero‐bilayers result in extremely weak photoresponsivity. Here, an infrared photodetector based on the MoS2/MoTe2 type‐II hetero‐bilayer is demonstrated to reach a photoresponsivity of 0.55 A W−1 at 1550 nm, well beyond energy band cut‐offs of monolayer MoS2 and MoTe2, primarily resulted from the photogating effect. Raman and photoluminescence (PL) spectroscopy reveal strong interlayer couplings in the hetero‐bilayer, and a broad PL peak around 1550 nm is observed that is ascribed to interlayer transitions of carriers. The photodetector showcases a broadband detection capability from 1100 to 1700 nm, with a peak at 1550 nm corresponding to the interlayer absorption. Electrical characterization of the hetero‐bilayer‐based field‐effect transistor and kelvin probe force microscopy reveal efficient interlayer hole transfer. The highly responsive MoS2/MoTe2 infrared photodetector offers a large photo‐gain of ≈103 and a time constant of 130 ms. The research illuminates how interlayer transitions affect 2D hetero‐bilayer‐based photodetectors and advances the utilization of layered semiconductor heterostructures.
Mechanism and kinetics of polycarbonate synthesized from isosorbide: Identification on the reactivity of terminal groups
Authors: Shen Jun‐Yao , Gao Xin‐Yi , Guo Wen‐Ze , Jiang Jie , Li Jin‐Jin , Zhao Ling , Xi Zhen‐Hao , Yuan Wei‐Kang 
Published: July 2024

AbstractChallenges in the mechanistic and kinetic study on the polymerization with multiple functional monomers hinder the scale‐up for the controllable reaction process. Herein, poly (isosorbide carbonate) synthesized from isosorbide (ISB) was employed to investigate the reaction behavior of functional monomers during polymerization. DFT calculations not only determined the energetically preferable pathways but also provided explanations for the significant differences between terminal groups at the molecular level. Subsequently, the characteristic absorption bands were detected from 1000 to 1100 cm−1 for hydroxyls on ISB, providing a quantitative measure for asymmetric hydroxyls. The reaction network indicated that the reactivity was dominated by the types of terminal groups instead of the chain length. Thereafter, a functional group model with six kinetic parameters was built, acting a crucial role in reaction control and reactor design. This method can be promoted to other functional monomers, conducing to the industrialization of high‐performance polymers.
Trend in physical growth among Chinese urban students: Results from five national successive cross‐sectional surveys within the past two decades
Authors: Zhang Shuai , Li Chengyue , Taerken Alimujiang·Yimiti 
Published: July 2024

AbstractObjectivesTo examine the orientation, magnitude, and pace of secular trends in body height, weight, and body mass index (BMI) among Chinese urban students aged 7–18 years from 2000 to 2019.MethodsData were extracted from Chinese urban students aged 7–18 years from the Chinese National Surveillance on Students' Constitution and Health in 2000, 2005, 2010, 2014, and 2019. The height, weight, and BMI of 548 419, 548 408, and 548 365 urban students aged 7–18 years, respectively, were tested. The mean differences across survey years were tested by one‐way analysis of variance (ANOVA). The pace of secular trends is expressed as the change every 5 years between every two adjacent survey years.ResultsHeight increments between 1.9 and 6.2 cm, weight increments between 2.7 and 8.6 kg, and BMI increments between 0.9 and 1.9 kg/m2 were observed in boys. For girls, height increments between 1.5 and 4.9 cm, weight increments between 2.2 and 6.0 kg, and BMI increments between 0.7 and 1.7 kg/m2 were observed. The pace of secular trends in height decreased in the last 5 years, and the secular trends in weight and BMI have accelerated in the last 9 years compared with the previous 10 years.ConclusionsAlthough the secular trend in height among Chinese urban students has slowed, it has not yet reached its genetic potential and continues to increase. The rapid increase in weight and BMI was a cause for concern. Our findings provide a basis for the future formulation of public health interventions in China.
Cutaneous ultrasound in the diagnosis and assessment of inflammatory activity in tinea capitis
Authors: Rodríguez‐Cuadrado Francisco José , Roustan‐Gullón Gaston , Alfageme‐Roldán Fernando 
Published: July 2024

AbstractIntroductionAlthough the diagnosis of tinea capitis is mainly microbiological, the risk of evolution towards cicatricial alopecia in the most severe cases requires empirical treatment based on physical examination and complementary examinations.MethodsTwo patients were evaluated by physical examination, cutaneous ultrasound and microbiological examination.ResultsUltrasound showed follicular widening and increased vascularization in Doppler mode. In one of them, the finding of severe inflammatory activity led to the indication of oral corticotherapy.DiscussionCutaneous ultrasound could play a role not only in supporting the clinical diagnosis but that it may even guide the indication of treatment in the presence of severe inflammation that sometimes may not manifest itself clinically.ConclusionCutaneous ultrasound may constitute an additional test of considerable usefulness in the diagnosis and evaluation of inflammatory activity in cases such as the ones presented, fast, non‐invasive and of high accessibility.
Clinical recognition of frontotemporal dementia with right anterior temporal predominance: A multicenter retrospective cohort study
Authors: Ulugut Hulya , Bertoux Maxime , Younes Kyan , Montembeault Maxime , Fumagalli Giorgio G. , Samanci Bedia , Illán‐Gala Ignacio , Kuchcinski Gregory , Leroy Melanie , Thompson Jennifer C. , Kobylecki Christopher , Santillo Alexander F , Englund Elisabet , Waldö Maria Landqvist , Riedl Lina , Van den Stock Jan , Vandenbulcke Mathieu , Vandenberghe Rik , Laforce Jr Robert , Ducharme Simon , Pressman Peter S. , Caramelli Paulo , de Souza Leonardo Cruz , Takada Leonel T. , Gurvit Hakan , Hansson Oskar , Diehl‐Schmid Janine , Galimberti Daniela , Pasquier Florence , Miller Bruce L. , Scheltens Philip , Ossenkoppele Rik , van der Flier Wiesje M. , Barkhof Frederik , Fox Nick C. , Sturm Virginia E. , Miyagawa Toji , Whitwell Jennifer L. , Boeve Bradley , Rohrer Jonathan D. , Gorno‐Tempini Maria Luisa , Josephs Keith A. , Snowden Julie , Warren Jason D. , Rankin Katherine P. , Pijnenburg Yolande A. L. ,   International rtvFTD Working Group
Published: July 2024

AbstractINTRODUCTIONAlthough frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance has been recognized, a uniform description of the syndrome is still missing. This multicenter study aims to establish a cohesive clinical phenotype.METHODSRetrospective clinical data from 18 centers across 12 countries yielded 360 FTD patients with predominant RATL atrophy through initial neuroimaging assessments.RESULTSCommon symptoms included mental rigidity/preoccupations (78%), disinhibition/socially inappropriate behavior (74%), naming/word‐finding difficulties (70%), memory deficits (67%), apathy (65%), loss of empathy (65%), and face‐recognition deficits (60%). Real‐life examples unveiled impairments regarding landmarks, smells, sounds, tastes, and bodily sensations (74%). Cognitive test scores indicated deficits in emotion, people, social interactions, and visual semantics however, lacked objective assessments for mental rigidity and preoccupations.DISCUSSIONThis study cumulates the largest RATL cohort unveiling unique RATL symptoms subdued in prior diagnostic guidelines. Our novel approach, combining real‐life examples with cognitive tests, offers clinicians a comprehensive toolkit for managing these patients.Highlights
This project is the first international collaboration and largest reported cohort.
Further efforts are warranted for precise nomenclature reflecting neural mechanisms.
Our results will serve as a clinical guideline for early and accurate diagnoses.
Epidural pressure measurement using a fiber‐optic sensor (proof‐of‐principle in vivo animal trial)
Authors: Barz Susanne , Friedemann Marvin , Voigt Sebastian , Melloh Markus , Barz Thomas 
Published: July 2024

AbstractBackgroundAn increase in epidural pressure around the stenosis has been observed in patients with lumbar spinal stenosis (LSS) with positive signs of sedimentation or redundant nerve roots. Further analysis of the pressure conditions in the stenotic area would be of great interest. We hypothesized that it would be possible to determine the physiological parameters of the epidural pulse wave and its course in pathological stenosis as a basis for objective identification of LSS based on pressure using a new measuring method with continuous spatial and temporal resolution.MethodsWe performed a single‐case proof‐of‐principle in vivo animal trial and used a newly developed hybrid pressure‐measurement probe with a fiber‐tip Fabry–Pérot interferometer and several fiber Bragg gratings (FBG).ResultsWith reproducible precision, we determined the mean epidural pressure to be 7.5 mmHg and the peak‐to‐peak value to be 4–5 mmHg. When analyzing the pressure measured by an FBG array, both the heart and respiratory rates can be precisely determined. This study was the first to measure the pulse wave velocity of the cerebrospinal fluid pressure wave as 0.97 m/s using the newly developed pressure probe. A simulated LSS was detected in real time and located exactly.ConclusionsThe developed fiber‐optic pressure sensor probe enables a new objective measurement of epidural pressure. We confirmed our hypothesis that physiological parameters of the epidural pulse wave can be determined and that it is possible to identify an LSS.
A Prediction Rule for the Dystonic Spread of Blepharospasm: A 4‐Year Prospective Cohort Study
Authors: Xing Ziwen , Hu Yue , Teng Fei , Song Yunping , Wu Zhuang , Hong Ronghua , Zhang Zhuoyu , Gu Hongkai , Peng Kangwen , He Yijing , Chen Yuhui , Pan Lizhen , Jin Lingjing 
Published: July 2024

ObjectiveBlepharospasm (BSP), focal dystonia with the highest risk of spread, lacks clear understanding of early spreading risk factors and objective prognostic indicators. We aimed to identify these risk factors through clinical and electrophysiological assessments, and to establish a predictive model for dystonic spread in BSP.MethodsWe prospectively followed BSP patients for 4 years, collecting data on dystonic spread, and conducting electrophysiological evaluations. The blink reflex, masseter inhibitory reflex, and trigeminal somatosensory evoked potential were assessed. Univariable and multivariable Cox proportional hazard regression models were used to assess clinical characteristics associated with BSP dystonic spread. A predictive model was constructed using a nomogram, and performance of the model was evaluated using the area under the receiver operating characteristic curve.ResultsA total of 136 enrolled participants (mean age 56.34 years) completed a 4‐year follow‐up. Among them, 62 patients (45.6%) showed spread to other body regions. Multivariable Cox regression analysis showed that a high Hamilton Anxiety Scale score (hazard ratio 1.19, 95% confidence interval 1.13–1.25, p < 0.001), prolonged trigeminal somatosensory evoked potential mandibular branch P1‐N2 peak interval (hazard ratio 1.11, 95% confidence interval 1.02–1.21, p = 0.017), and elevated trigeminal somatosensory evoked potential mandibular branch P1‐N2 peak amplitude (hazard ratio 1.26, 95% confidence interval 1.12–1.41, p < 0.001) were independent risk factors for BSP dystonic spread within 4 years. Combining these factors, the predictive models demonstrated excellent discriminative ability, with the receiver operating characteristic curve score being 0.797, 0.790, 0.847, and 0.820 at 1, 2, 3 and 4 years after enrollment, respectively.InterpretationWe established a predictive model with significant value for anticipating dystonic spread in BSP, offering crucial evidence. These findings contribute essential insights into the early clinical identification of the development and evolution of BSP diseases. ANN NEUROL 2024;96:747–757