bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trust‐aware and link‐reliable routing metric composition for wireless sensor networks
Authors: Velivasaki Terpsichori‐Helen N. , Karkazis Panagiotis , Zahariadis Theodore V. , Trakadas Panagiotis T. , Capsalis Christos N. 
Published: October 2012

ABSTRACTThe usability of wireless sensor networks in modern applications requires the fulfillment of dynamic Quality of Service (QoS) requirements that can only be met in a reactive manner by the introduction of composite routing metrics, capturing several distinct network characteristics. However, combining routing metrics is neither a trivial nor an arbitrary task, given the routing protocol requirements and routing metrics properties. In this paper, the theoretical framework of routing algebra formalism is adopted and extended to incorporate single or composite routing metrics, because the satisfaction of routing algebra properties ensures convergence, optimality, and loop‐freeness. Moreover, packet forwarding indication is defined as a new trust metric for systems (a) with or (b) without network retransmissions to avoid forwarding attacks, while a novel composite routing metric is presented, combining link reliability and trust‐awareness in an additive manner, fulfilling the theoretical requirements. Finally, this composite metric is applied to the Routing Protocol for Low Power and Lossy Networks via simulations, which verify its efficiency in several scenarios, including the comparison between lexical and additive metric composition approaches. Copyright © 2012 John Wiley & Sons, Ltd.
Hypoxia‐inducible factors as key regulators of tumor inflammation
Authors: Mamlouk Soulafa , Wielockx Ben 
Published: October 2012

AbstractLow levels of oxygen or hypoxia is often an obstacle in health, particularly in pathological disorders like cancer. The main family of transcription factors responsible for cell survival and adaptation under strenuous conditions of hypoxia are the “hypoxia‐inducible factors” (HIFs). Together with prolyl hydroxylase domain enzymes (PHDs), HIFs regulates tumor angiogenesis, proliferation, invasion, metastasis, in addition to resistance to radiation and chemotherapy. Additionally, the entire HIF transcription cascade is involved in the “seventh” hallmark of cancer; inflammation. Studies have shown that hypoxia can influence tumor associated immune cells toward assisting in tumor proliferation, differentiation, vessel growth, distant metastasis and suppression of the immune response via cytokine expression alterations. These changes are not necessarily analogous to HIF's role in non‐cancer immune responses, where hypoxia often encourages a strong inflammatory response.
Altered expression and localization of insulin receptor in proximal tubule cells from human and rat diabetic kidney
Authors: Gatica Rodrigo , Bertinat Romina , Silva Pamela , Carpio Daniel , Ramírez María José , Slebe Juan Carlos , Martín Rody San , Nualart Francisco , Campistol Jose María , Caelles Carme , Yáñez Alejandro J. 
Published: October 2012

AbstractDiabetes is the major cause of end stage renal disease, and tubular alterations are now considered to participate in the development and progression of diabetic nephropathy (DN). Here, we report for the first time that expression of the insulin receptor (IR) in human kidney is altered during diabetes. We detected a strong expression in proximal and distal tubules from human renal cortex, and a significant reduction in type 2 diabetic patients. Moreover, isolated proximal tubules from type 1 diabetic rat kidney showed a similar response, supporting its use as an excellent model for in vitro study of human DN. IR protein down‐regulation was paralleled in proximal and distal tubules from diabetic rats, but prominent in proximal tubules from diabetic patients. A target of renal insulin signaling, the gluconeogenic enzyme phosphoenolpyruvate carboxykinase (PEPCK), showed increased expression and activity, and localization in compartments near the apical membrane of proximal tubules, which was correlated with activation of the GSK3β kinase in this specific renal structure in the diabetic condition. Thus, expression of IR protein in proximal tubules from type 1 and type 2 diabetic kidney indicates that this is a common regulatory mechanism which is altered in DN, triggering enhanced gluconeogenesis regardless the etiology of the disease. J. Cell. Biochem. 114: 639–649, 2013. © 2012 Wiley Periodicals, Inc.
Regulation of immediate‐early gene transcription following activation of Gαq‐coupled designer receptors
Authors: Kaufmann Anke , Keim Anja , Thiel Gerald 
Published: October 2012

AbstractG‐protein coupled designer receptors that are specifically activated by designer drugs have been developed. Here, we have analyzed the regulation of gene transcription following activation of Gαq‐coupled designer receptor (Rαq). Stimulation of human embryonic kidney (HEK) 293 cells expressing Rαq with clozapine‐N‐oxide (CNO), a pharmacologically inert compound, induced the expression of biologically active Egr‐1, a zinc finger transcription factor. Expression of a dominant‐negative mutant of the ternary complex factor (TCF) Elk‐1, a key transcriptional regulator of serum response element (SRE)‐driven gene transcription, prevented Egr‐1 expression. Stimulation of Rαq with CNO increased the transcriptional activation potential of Elk‐1 and enhanced transcription of an SRE regulated reporter gene. In addition, AP‐1 transcriptional activity was significantly elevated. AP‐1 activity was controlled by TCFs and c‐Jun in cells expressing an activated Gαq‐coupled designer receptor. CNO stimulation did not increase Egr‐1 and AP‐1 activity in neuroblastoma cells expressing endogenous M3 muscarinic acetylcholine receptors, indicating that CNO did not function as a ligand for these receptors. Rαq stimulation also increased the transcriptional activation potential of CREB and cAMP response controlled gene transcription. Pharmacological and genetic experiments revealed that the protein kinases Raf and ERK were essential to connect Rαq stimulation with enhanced Egr‐1 and AP‐1 controlled transcription. In contrast, MAP kinase phosphatase‐1 functioned as a nuclear shut‐off device of stimulus‐transcription coupling. The fact that Rαq stimulation activates the transcription factors Egr‐1, Elk‐1, AP‐1, and CREB indicates that regulation of gene transcription is an integral part of Gαq‐coupled receptor signaling. J. Cell. Biochem. 114: 681–696, 2013. © 2012 Wiley Periodicals, Inc.
Neuroprotective effects of PrxI over‐expression in an in vitro human Alzheimer's disease model
Authors: Cimini Annamaria , Gentile Roberta , Angelucci Francesco , Benedetti Elisabetta , Pitari Giuseppina , Giordano Antonio , Ippoliti Rodolfo 
Published: October 2012

AbstractPeroxiredoxins are ubiquitous proteins that recently attracted major interests in view of the strict correlation observed in several cell lines and/or tissues between different levels of their expression and the increased capacity of cells to survive in different pathophysiological conditions. They are recently considered as the most important enzymes regulating the concentration of hydroperoxides inside the cells. Most of neurodisorders such as Parkinson, Huntington, Alzheimer's diseases, and ischemic injury are characterized by conditions of oxidative stress inside cells. In these pathophysiological conditions, a strict correlation between cell survival and Prx expression has been found. In CNS all the Prx isoforms are present though with different expression pattern depending on cell phenotype. Interestingly, neurons treated with amyloid beta peptide (Aβ), showed an overexpression of PrxI. In this study, the neuroprotective effect of PrxI after Aβ exposure and the underlying mechanisms by which PrxI expression counteracts cell death was investigated in a well established human AD in vitro model. Taking advantage on cells transfected by a construct where human PrxI is fused with a Green fluorescent protein (GFP) at the C‐terminus, we report some events at the basis of cell survival after Aβ injury, suggesting possible new signal cascades dealing with the antiapoptotic effect of PrxI. The results obtained indicated a protective role for PrxI in counteracting Aβ injury by increasing cell viability, preserving neurites, and decreasing cell death. J. Cell. Biochem. 114: 708–715, 2013. © 2012 Wiley Periodicals, Inc.
Identification of candidate downstream targets of TGFβ signaling during palate development by genome‐wide transcript profiling
Authors: Pelikan Richard C. , Iwata Junichi , Suzuki Akiko , Chai Yang , Hacia Joseph G. 
Published: October 2012

AbstractNonsyndromic orofacial clefts are common birth defects whose etiology is influenced by complex genetic and environmental factors and gene–environment interactions. Although these risk factors are not yet fully elucidated, it is known that alterations in transforming growth factor‐beta (TGFβ) signaling can cause craniofacial abnormalities, including cleft palate, in mammals. To elucidate the downstream targets of TGFβ signaling in palatogenesis, we analyzed the gene expression profiles of Tgfbr2fl/fl;Wnt1‐Cre mouse embryos with cleft palate and other craniofacial deformities resulting from the targeted inactivation of the Tgfbr2 gene in their cranial neural crest (CNC) cells. Relative to controls, palatal tissues obtained from Tgfbr2fl/fl;Wnt1‐Cre mouse embryos at embryonic day 14.5 (E14.5) of gestation have a robust gene expression signature reflective of known defects in CNC‐derived mesenchymal cell proliferation. Groups of differentially expressed genes (DEGs) were involved in diverse cellular processes and components associated with orofacial clefting, including the extracellular matrix, cholesterol metabolism, ciliogenesis, and multiple signaling pathways. A subset of the DEGs are known or suspected to be associated with an increased risk of orofacial clefting in humans and/or genetically engineered mice. Based on bioinformatics analyses, we highlight the functional relationships among differentially expressed transcriptional regulators of palatogenesis as well as transcriptional factors not previously associated with this process. We suggest that gene expression profiling studies of mice with TGFβ signaling defects provide a valuable approach for identifying candidate mechanisms by which this pathway controls cell fate during palatogenesis and its role in the etiology of human craniofacial abnormalities. J. Cell. Biochem. 114: 796–807, 2013. © 2012 Wiley Periodicals, Inc.
Change in Cognitive Errors and Coping Over the Course of Brief Psychodynamic Intervention
Authors: Kramer Ueli , de Roten Yves , Drapeau Martin , Despland Jean‐Nicolas 
Published: October 2012

ObjectiveCognitive change over the course of psychodynamic psychotherapy has been postulated by several models, but has rarely been studied. Based on the adaptive skills model (Badgio, Halperin, & Barber, 1999), it is reasonable to expect that very brief dynamic psychotherapy may be associated with change in coping patterns and cognitive errors (also known as cognitive distortions) y.MethodN = 50 outpatients presenting with various psychiatric disorders and undergoing 4 sessions of Brief Psychodynamic Intervention (BPI; Despland, Drapeau, & de Roten, 2005; Despland, Michel, & de Roten, 2010) were included in this naturalistic study (mean age: 31 years; 56% female; all Caucasian). Cognitive errors and coping strategies were assessed using the Cognitive Errors Rating Scale (Drapeau et al., 2008) and Coping Patterns Rating Scale (Perry et al., 2005). These observer rated methods were applied to the verbatim transcriptions of all 4 therapy sessions completed by each patient.ResultsResults indicate change in both cognitive errors and coping patterns over the course of BPI, including an increase in the Overall Coping Functioning and a decrease in unhelpful coping processes, such as isolation, which reflects a shift in participant appraisal towards stress appraised as a challenge at the end of treatment. These changes predicted symptom change at the end of treatment. While cognitive errors also changed over the course of BPI, no predictive effect was found with regard to symptom change.ConclusionsThese results are interpreted within the framework of common change principles in psychotherapy. Implications and future research are discussed.
Novel proton MR spectroscopy findings in adenylosuccinate lyase deficiency
Authors: Zulfiqar Maria , Lin Doris D.M. , Van der Graaf Marinette , Barker Peter B. , Fahrner Jill A. , Marie Sandrine , Morava Eva , De Boer Lonneke , Willemsen Michel A.A.P. , Vining Eileen , Horská Alena , Engelke Udo , Wevers Ron A. , Maegawa Gustavo H.B. 
Published: October 2012

AbstractAdenylosuccinate lyase (ADSL) deficiency is a rare inborn error of metabolism resulting in accumulation of metabolites including succinylaminoimidazole carboxamide riboside (SAICAr) and succinyladenosine (S‐Ado) in the brain and other tissues. Patients with ADSL have progressive psychomotor retardation, neonatal seizures, global developmental delay, hypotonia, and autistic features, although variable clinical manifestations may make the initial diagnosis challenging. Two cases of the severe form of the disease are reported here: an 18‐month‐old boy with global developmental delay, intractable neonatal seizures, progressive cerebral atrophy, and marked hypomyelination, and a 3‐month‐old girl presenting with microcephaly, neonatal seizures, and marked psychomotor retardation. In both patients in vivo proton magnetic resonance spectroscopy (MRS) showed the presence of S‐Ado signal at 8.3 ppm, consistent with a prior report. Interestingly, SAICAr signal was also detectable at 7.5 ppm in affected white matter, which has not been reported in vivo before. A novel splice‐site mutation, c.IVS12 + 1/G > C, in the ADSL gene was identified in the second patient. Our findings confirm the utility of in vivo proton MRS in suggesting a specific diagnosis of ADSL deficiency, and also demonstrate an additional in vivo resonance (7.5 ppm) of SAICAr in the cases of severe disease. J. Magn. Reson. Imaging 2013;37:974–980. © 2012 Wiley Periodicals, Inc.
Numerical investigation of zoomable holographic projection without a zoom lens
Authors: Shimobaba Tomoyoshi , Kakue Takashi , Masuda Nobuyuki , Ito Tomoyoshi 
Published: October 2012

AbstractHolographic projection is for laser displays and has the merits of being aberration free, producing high‐contrast images, having the ability of color reconstruction with one spatial light modulator, and so on. In this paper, we propose a zoomable holographic projection without using a zoom lens and verify the proposed method by using numerical simulation. Although such a system can be readily realized to use the features of holography, which is capable of recording a large image exceeding the hologram size, the required calculation is very time consuming. For acceleration, we used shifted Fresnel diffraction for setting different sampling rates on a hologram and projected image. The proposed method can project any zoom‐in and zoom‐out image between zeroth‐order and first‐order lights, and the processing time and required memory for the zoom are constant.
The effects of a 1.8 GHz continuous electromagnetic fields on mucociliary transport of human nasal mucosa
Authors: In Seung Min , Kim Hyun Jun , Park Rae Woong , Kim Woojae , Gimm Yoon‐Myoung , Park Ikmo , Hong Sungpyo , Hong Jeong Joo , Oh Jeong Hyun , Kahng Hison , Park Eun Young 
Published: October 2012

AbstractObjectives/Hypothesis:The aim of this study was to investigate the effects of a 1.8 GHz continuous electromagnetic fields (EMF) on human nasal mucociliary transport, and to determine the pathophysiology of ciliary beat frequency (CBF) during an EMF‐induced change.Methods:Human nasal mucosa cells were exposed to a 1.8 GHz EMF (SAR=1.0 W/kg), and CBF was analyzed using an optical flow technique with the peak detection method.Results:The 1.8 GHz‐exposed group showed a decreased CBF when compared to the control group. In the cytotoxicity assay, difference in survival rates was not found between the two groups. In the EMF‐exposed group, protein kinase C (PKC) activity was increased during a PKC activity assay. The broad PKC inhibitor, Calphostin C abolished the EMF‐induced decrease of CBF. The EMF‐induced decrease of CBF was abolished by GF 109203X, a novel PKC (nPKC) isoform inhibitor, whereas the decrease was not attenuated by Gö‐6976, a specific inhibitor of conventional PKC (cPKC) isoform.Conclusions:EMF may inhibit CBF via an nPKC‐dependent mechanism. Therefore, we have confirmed that EMF could decrease CBF by increasing PKC activity. Laryngoscope, 2012
The Match between Information Control and Motivation in the Online Context
Authors: Wu Ling‐Ling , Lin Jia‐Yan 
Published: October 2012

ABSTRACTE‐commerce practitioners have long tried to leverage the technological characteristics of the Internet to facilitate better information seeking and decision making by consumers online. One impressive characteristic of the Internet is that it offers users various degrees of information control on the same medium. The purpose of this study is to investigate the effects of this characteristic on consumers’ decision‐making online. It is hypothesized that, to improve quality of consumers’ decisions, the degree of information control should match the degree of motivation. The rationale is that highly motivated consumers have a strong will to search for relevant information; therefore, a high degree of information control allows them to search as much as they want and thereby improve their decision making. Low‐motivation consumers, on the other hand, are unwilling to search; hence a low degree of information control, which might push high‐quality information, would benefit them. The study employed the methodology of experiment, and involved 171 voluntary participants. The empirical results show that high‐motivation consumers make better decisions when they are given a high degree of information control, compared to when they are in a low information control condition. On the other hand, low‐motivation consumers in a low information control condition perform better than similar consumers in a high‐control condition. The results strongly support the match hypothesis of information control.
Propeller DICAP flap for a large defect on the back—Case report and review of the literature
Authors: Prasad Vani , Morris Steven F. 
Published: October 2012

AbstractReconstruction of large soft tissue defects of the back is a challenging problem. Large defects of the back were reconstructed with multiple random pattern or local pedicled muscle (and skin graft) or musculocutaneous flaps. The clinical use of perforator flaps has demonstrated that harvesting of flaps on a single perforator is possible for reconstruction of large defects. We present a 71‐year‐old male with a lesion on his left mid back that measured 10 × 10 × 4 cm3. Biopsy of the lesion was consistent with dermatofibrosarcoma protruberans. Wide local excision of the lesion with 4 cm margin was performed. The soft tissue defect, ∼20 cm in diameter, was reconstructed with a large propeller dorsal intercostal artery perforator (DICAP) flap. The DICAP flap measured 40 × 15 cm2 based on a single perforator—lateral branch of dorsal rami of the seventh posterior intercostal artery on the right side. The perforator flap was elevated at the subfascial level and transposed 180° into the defect. The donor site on the right side of the back was closed directly. This case illustrates the size of the propeller DICAP flap that could be safely harvested on a single perforator from the dorsal rami of the posterior intercostal artery. To our knowledge this is the largest reported pedicled perforator flap harvested on a single perforator on the posterior trunk. © 2012 Wiley Periodicals, Inc. Microsurgery, 2012.
Measurement of cross‐sectional area of cervical roots and brachial plexus trunks
Authors: Won Sun Jae , Kim Byung‐Jo , Park Kyung Seok , Kim Se Hwa , Yoon Joon Shik 
Published: October 2012

AbstractIntroduction: The aim of this study was to determine normal reference values for cross‐sectional area (CSA) and the correlation between demographic factors and CSA in the cervical roots and brachial plexus trunks using ultrasonography. Methods: Ninety‐five age‐matched healthy individuals were studied. Ultrasonographic tests were performed via nerve tracing from the cervical root to the brachial plexus trunk. The CSA of each nerve was measured in the C5–8 ventral roots and brachial plexus (trunk level). Results: Normal values of each cervical root were: C5, 5.66 ± 1.02 mm2; C6, 8.98 ± 1.65 mm2; C7, 10.43 ± 1.86 mm2; and C8, 10.76 ± 2.02 mm2. Values for the brachial plexus were: upper trunk, 16.70 ± 2.88 mm2; middle trunk, 14.01 ± 2.70 mm2; and lower trunk, 13.75 ± 2.57 mm2. The side‐to‐side discrepancy was 11.91 ± 11.11%. Body mass index (BMI) and height correlated frequently with nerve CSA. Conclusions: These reference values may be helpful in investigating pathologies involving the cervical area. Muscle Nerve 46: 711–716, 2012
Modification of phenolic resin composites by hyperbranched polyborate and polybenzoxazine
Authors: Xu Peijun , Yang Feipeng 
Published: October 2012

AbstractHyperbranched polyborate (HBPB) is a novel polymer with highly branched structures, plenty of functional end groups, and excellent thermal resistance, which could be used as an effective modifier for thermoset resin to greatly improve the thermal resistance and toughness of the resin, simultaneously. With the assistance of benzoxazine (BOZ) resin which has low viscosity, high thermal resistance, and no by‐product release upon curing, modification effects of HBPB on the thermal resistance and toughness of phenolic resin (PR) can be adequately realized. The optimal combination of HBPB and BOZ modified PR (PR‐BOZ‐HBPB) is obtained by the orthogonal test. The PR‐BOZ‐HBPB blend prepared with the optimal combination (90 portion of PR, 10 portion of BOZ, and 5 portion of HBPB) has a char yield up to 67.4%; meanwhile, flexural strength, interlaminar shear strength, flexural modulus of this glass/PR‐BOZ‐HBPB composite are higher than those of glass/PR composite by 17.6%, 23.3%, and 9.6%, respectively. The novel thermoset resin, PR‐BOZ‐HBPB blend, which consists of good processability, great thermal and mechanical properties, is obtained. POLYM. COMPOS., 33:1960–1968, 2012. © 2012 Society of Plastics Engineers
Non‐food application of camelina meal: Development of sustainable and green biodegradable paper‐camelina composite sheets and fibers
Authors: Kim Jun Tae , Netravali Anil N. 
Published: October 2012

AbstractRecycled newspaper‐reinforced sustainable and biodegradable composite sheets and fibers were fabricated with camelina meal, a by‐product of camelina oil extraction‐based resin. To prepare uniform composite sheets and fibers, the camelina meal was ground and sieved to remove large particles and some impurities and converted into resin by dissolving it in water and precuring at 75°C water bath. Sieving process improved protein contents by 4.7% and reduced fat contents by 4.2%. Recycled newspaper was used as a reinforcing agent to improve tensile properties and increase water resistance of the camelina meal‐based biodegradable composite sheets and fibers. Increasing newspaper content increased fracture stress, Young's modulus, and water resistance property. However, the uniform sheet could not be formed when recycled newspaper content was above 30% (wt/wt camelina). Scanning electron microscope photomicrographs of fracture surfaces showed that at higher newspaper content longer fibers protruded out from the camelina resin. POLYM. COMPOS., 33:1969–1976, 2012. © 2012 Society of Plastics Engineers