bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adequacy of usual intake of Japanese college athletes in various sports clubs
Authors: Kakutani Yuya , Ono Miho , Sasahara Ikuko , Omi Naomi 
Published: August 2024

Background While many studies have been published on nutrient intake assessment for performance improvement and deficiency prevention in single-sport athletes, few studies have addressed nutrient intakes in athletes from a various sports. Aim The aim of this study was to determine whether Japanese college athletes meet the Dietary Reference Intakes (DRIs) and sports nutrition recommendations (SNRs). Methods Dietary intake was assessed in 1049 Japanese college athletes from a variety of sports using a validated brief-type self-administered diet history questionnaire. The prevalence of inadequate intakes was estimated by comparing the DRIs and SNRs. Results For protein, riboflavin, niacin, vitamins B-6, vitamins B-12, folate, magnesium, zinc, and copper, <10% of females and males consumed diets that fell below the estimated average requirement (EAR) in the DRIs. A large proportion of female and male college athletes demonstrated intakes that were below the EAR for vitamin A (7.8% and 19.0%, respectively), thiamin (10.4% and 23.9%, respectively), calcium (20.4% and 29.7%, respectively), and iron (24.2% and 2.5%, respectively). Regarding DG for chronic disease prevention in the DRIs, over half of both female and male athletes exceeded the DG for saturated fat acid and sodium, and fell below the DG for dietary fiber. Few of both female and male had intakes below the SNRs for protein and carbohydrates. Conclusion The results of the present study reveal the nutrient intake status of Japanese college athletes by comparing the DRIs and SNRs. Most meet the SNRs for optimal performance, but not the DRIs for health.
Common protein networks for various drug regimens of major depression are associated with complement and immunity
Authors: Lee Seungyeon , Mun Sora , Lee Jiyeong , Kang Hee-Gyoo 
Published: August 2024

Background: Major depressive disorder (MDD) can present a variety of clinical presentations and has high inter-individual heterogeneity. Multiple studies have suggested various subtype models related to symptoms, etiology, sex, and treatment response. Employing different regimens is common when treating MDD, and identifying effective therapeutics requires time. Frequent treatment attempts and failures can lead to a diagnosis of treatment resistance, and the heterogeneity of treatment responses among individuals makes it difficult to understand and interpret the biological mechanisms underlying MDD. Aim: This study explored the differentially expressed proteins and commonly altered protein networks across drug treatments by comparing the serum proteomes of patients with MDD treated with drug regimens (T-MDD, n = 20) and untreated patients (NT-MDD, n = 20). Methods: Differentially expressed proteins were profiled in non-drug-treated and drug-treated patients with depression using liquid chromatography-mass spectrometry. The common protein networks affected by different medications were studied. Results: Of the proteins profiled, 12 were significantly differentially expressed between the T-MDD and NT-MDD groups. Commonly altered proteins and networks of various drug treatments for depression were related to the complement system and immunity. Conclusions: Our results provide information on common biological changes across different pharmacological treatments employed for depression and provide an alternative perspective for improving our understanding of the biological mechanisms of drug response in MDD with great heterogeneity in the background of the disease.
Hypermethylation of genes on chromosome 3p as a biomarker for nasopharyngeal carcinoma diagnosis: A Vietnamese case-control study
Authors: Lao Thuan Duc , Le Thuy Ai Huyen 
Published: August 2024

Background The crucial event driving nasopharyngeal tumorigenesis is the hypermethylation of chromosome 3p-located tumor suppressor genes. This case-control study aims to investigate the methylation characteristics of RASSF1A, Blu, ADAMTS9, and DLEC1 to potentially develop effective diagnostic biomarkers for nasopharyngeal carcinoma, either individually or in combination. Methods The methylation of RASSF1A, Blu, ADAMTS9, and DLEC1 in the collection of 93 biopsy samples and 100 healthy swab specimens were evaluated by Nested methylation-specific polymerase chain reaction. The strength of the correlation between candidate genes and nasopharyngeal carcinoma was estimated by the evaluation of odds ratios (ORs). Results Promoter hypermethylation of RASSF1A, Blu, ADAMTS9, and DLEC1 were found in 60.22%, 80.65%, 62.37%, and 74.19%, respectively, in nasopharyngeal carcinoma tumors. A significant association between the methylation status of candidate genes with nasopharyngeal carcinoma was reported. The methylation of candidate genes significantly increased the risk of nasopharyngeal carcinoma in cancerous samples compared with control samples (OR > 1). Based on the value of the methylation index, methylation of at least one gene was found in 95.70% of nasopharyngeal tumors. Additionally, the methylation index among 93 tumors significantly correlated with advanced stage nasopharyngeal tumors. Conclusion The study explored a higher frequency of hypermethylation at least one candidate gene. Methylation of a panel of potential genes can be utilized to discriminate between nasopharyngeal carcinoma and non-cancer cells, particularly in the advanced stages of nasopharyngeal carcinoma. Thus, it could serve as a valuable marker for the diagnosis and monitoring of nasopharyngeal carcinoma.
Response of seawater sea sand coral aggregate concrete columns reinforced with hybrid glass fiber reinforced polymer and stainless steel bars under axial compression
Authors: Cao Qi , Jia Zongke , Wu Zhimin , Ma Zhongguo J 
Published: August 2024

The potential application prospects for concrete structure in island engineering and marine structures are increasing through the utilization of concrete composed of seawater, sea sand and coral aggregates (SSCC) combined with hybrid reinforcement. This innovative approach effectively addresses the diminishing availability of freshwater and river sand resources, as well as steel corrosion. This study explores the axial load carrying capacity and ductility of columns reinforced with combination of stainless steel bars and GFRP bars. The study conducted tests on 36 columns, varying in strengths (30 MPa, 40 MPa, 50 MPa), reinforcement types (GFRP bars (G group), stainless steel bars (S group), GFRP bars-stainless steel bars (GS group)), and reinforcement ratios (1.01%, 1.56%, 2.26%). The results exhibit positive correlation between the axial load carrying capacity of the column and both the strength grade and reinforcement ratio. In general, SSCC columns reinforced with stainless steel bars (S-SSCC) exhibit the highest axial load carrying capacity, followed by those reinforced with combination of GFRP bars and stainless steel bars (GS-SSCC), and SSCC columns reinforced with GFRP bars (G-SSCC) exhibit the lowest axial load carrying capacity. Furthermore, the axial load carrying capacity was determined utilizing ACI 440, CSA S806 and the finite element software ABAQUS. The results derived from the analytical model exhibited strong agreement with those obtained experimentally. Ductility analysis results suggest that columns with hybrid reinforcement can significantly improve ductility compared to those with only GFRP bars.
Supporting Older Adults’ Mental Health Against Suspected Mental Health Problems: The Moderating Role of an Age-Friendly Neighborhood
Authors: Leung Dara Kiu Yi , Yiu Eric Kwok Lun , Liu Tianyin , Zhang Wen , Kwok Wai-Wai , Sze Lesley Cai Yin , Wong Gloria Hoi Yan , Lum Terry Yat Sang 
Published: August 2024

This study examined how compensatory and enabling domains of an Age-Friendly City (AFC) moderate the relationship between suspected mental health problems and depressive and anxiety symptoms among older adults. Four thousand six hundred and twenty-five Hong Kong Chinese aged ≥60 years completed a telephone survey between April and July 2022, including PHQ-2 and GAD-2. AFC indices sourced from prior territory-wide study. Linear mixed models showed that enabling AFC domains, namely, social participation, respect and social inclusion, and civic participation and employment, alleviated the effects of suspected mental health problems on respondents’ depressive and anxiety symptoms (b = −0.40 to −0.56). Three-way interaction models revealed that the protective effects of all compensatory and enabling AFCC domains (b = −1.23 to −6.18), except civic participation and employment, were stronger in old-old (70–79 years) and oldest-old (≥80 years) than young-old (60–69 years). AFCC-based interventions should focus on compensatory and enabling domains to support older adults’ mental health.
Artificial Intelligence-Based Models for Prediction of Mortality in ICU Patients: A Scoping Review
Authors: Olang Orkideh , Mohseni Sana , Shahabinezhad Ali , Hamidianshirazi Yasaman , Goli Amireza , Abolghasemian Mansour , Shafiee Mohammad Ali , Aarabi Mehdi , Alavinia Mohammad , Shaker Pouyan 
Published: August 2024

Background and Objective Healthcare professionals may be able to anticipate more accurately a patient's timing of death and assess their possibility of recovery by implementing a real-time clinical decision support system. Using such a tool, the healthcare system can better understand a patient's condition and make more informed judgements about distributing limited resources. This scoping review aimed to analyze various death prediction AI (Artificial Intelligence) algorithms that have been used in ICU (Intensive Care Unit) patient populations. Methods The search strategy of this study involved keyword combinations of outcome and patient setting such as mortality, survival, ICU, terminal care. These terms were used to perform database searches in MEDLINE, Embase, and PubMed up to July 2022. The variables, characteristics, and performance of the identified predictive models were summarized. The accuracy of the models was compared using their Area Under the Curve (AUC) values. Results Databases search yielded an initial pool of 8271 articles. A two-step screening process was then applied: first, titles and abstracts were reviewed for relevance, reducing the pool to 429 articles. Next, a full-text review was conducted, further narrowing down the selection to 400 key studies. Out of 400 studies on different tools or models for prediction of mortality in ICUs, 16 papers focused on AI-based models which were ultimately included in this study that have deployed different AI-based and machine learning models to make a prediction about negative patient outcome. The accuracy and performance of the different models varied depending on the patient populations and medical conditions. It was found that AI models compared with traditional tools like SAP3 or APACHE IV score were more accurate in death prediction, with some models achieving an AUC of up to 92.9%. The overall mortality rate ranged from 5% to more than 60% in different studies. Conclusion We found that AI-based models exhibit varying performance across different patient populations. To enhance the accuracy of mortality prediction, we recommend customizing models for specific patient groups and medical contexts. By doing so, healthcare professionals may more effectively assess mortality risk and tailor treatments accordingly. Additionally, incorporating additional variables—such as genetic information—into new models can further improve their accuracy.
Acrylonitrile butadiene styrene/multi-walled carbon nanotubes nanocomposite foams for electromagnetic interference shielding with optimized performance
Authors: Azerang Bashar , Azdast Taher , Doniavi Ali , Hasanzadeh Rezgar 
Published: August 2024

The advancement of polymeric nanocomposite foams for electromagnetic interference (EMI) shielding can be credited to two main factors: the multiple deflections of the incoming electromagnetic waves within the shield and the formation of conductive pathways by the nanofillers. In this research, chemical foaming is employed in injection molding machine to create foams made of acrylonitrile butadiene styrene (ABS) and multi-walled carbon nanotubes (MWCNTs). By incorporating a 1 wt% concentration of MWCNT, applying a pressure time of 2 s, and allowing for a cooling time of 60 s, foamed nanocomposite samples demonstrated a remarkable total EMI shielding effectiveness (SE) of SET = 16.25 dB. This SE value surpassed the EMI SE values of the remaining samples across the X-band frequency range. Upon comparing foamed samples of pure and nanocomposite materials with identical cell density, it was observed that the enhancement of SET for the nanocomposite foamed sample reached 21.2% in contrast to the pure foamed sample operating at 11.52 GHz. The research revealed that incorporating a microcellular structure had a notable impact on the electrical conductivity, relative permittivity, dielectric loss, relative permeability, and magnetic loss in ABS/MWCNT nanocomposites. Furthermore, the nanocomposite foams demonstrated significantly greater EMI SE in comparison to their solid counterparts.
Developing and validating a clinical risk score to predict losses in the PISCIS cohort of people with HIV
Authors: Palacio-Vieira Jorge , Díaz Yesika , Moreno-Fornés Sergio , Bruguera Andreu , Nomah Daniel K. , Llibre Josep M. , Knobel Hernando , Chivite Iván , Miró José M. , Suanzes Paula , Fanjul Francisco , Navarro Gemma , Macorigh Lizza , Homar Borràs Francesc , Vilaró López Ingrid , Orti Llaveria Amat Joaquim , Casabona Jordi , Imaz Arkaitz , Reyes-Urueña Juliana ,   PISCIS Study Group
Published: August 2024

Background People lost to follow-up (LTFU) from HIV care have an increased risk of worse health. The objective of this study is to create and validate a risk score to predict LTFU among PLWH in Catalonia and the Balearic Islands. Methods 6661 PLWH were included. LTFU were those without contact with HIV care for 12 months or more. Logistic regression models were used to assess the role of independent factors on LTFU. The validation included a 10-fold iteration to predict the performance of the regression model and the Area under the ROC Curve (AUC). Regression coefficients were rounded and summed to construct the score. Results Determinants of LTFU included being younger than 34 years (OR: 1.80, CI, 1.44–2.23), not having been born in Spain (OR: 1.32, 1.11–1.58), men who inject drugs (OR: 2.10, 1.38–3.19), having a detectable viral load (OR: 3.14, 2.47–3.99), and ≤2.5 years since HIV diagnosis (OR: 3.84, 3.10–4.75). The validation of determinants resulted in a mean AUC of 0.69 and the risk-score revealed that 28.8% had a medium and 3.4% a high risk of LTFU respectively. Conclusions Findings can be used to prevent LTFU in HIV care.
Treatment patterns in patients with systemic lupus erythematosus in New Zealand
Authors: Lao Chunhuan , Dantzig Philippa Van , Tugnet Nikki , Lawrenson Ross , White Douglas 
Published: August 2024

Objectives This study aims to explore the treatment pattern of systemic lupus erythematosus (SLE) in Aotearoa/New Zealand. Methods SLE patients were linked to the pharmaceutical dispensing data. The use of publicly funded anti-malarials, immunomodulators, biologics, glucocorticoids and bisphosphonates were compared by gender, ethnicity, age group, socioeconomic status and year of SLE identification. Adherence to hydroxychloroquine was examined using the medication possession ratio (MPR), with a MPR of ≥0.8 considered as high adherence. Results Of the 2631 SLE patients, 73.8% used hydroxychloroquine, 64.1% used immunomodulators/biologics and 68.0% used 5 mg or more prednisone daily for at least 90 days. Women were more likely to use hydroxychloroquine than men. Asian patients had a different treatment pattern than other ethnic groups, and Māori were less likely to use hydroxychloroquine. The proportions of patients using different treatments decreased with age. Of the patients using hydroxychloroquine, 54.5% had high adherence. For patients over 40 years old and on long term prednisone, 47.3% had bisphosphonates and this figure was 17.8% for patients under the age of 40 years old. Patients with better socioeconomic status had a higher probability of using bisphosphonates than patients with lower socioeconomic status. Conclusions Adherence to hydroxychloroquine in these patients varied and was lower in men and in Māori. Prednisone is commonly prescribed and used long term. Half of those over the age of 40 years old co-administered bisphosphonate. Further research is needed to identify the reasons for these discrepancies on SLE treatments by gender, ethnicity, age and socioeconomic status.
Utility of pan-immune-inflammation value as a predictor of the prognosis of childhood lupus
Authors: Alasmari Ali , Aldakhil Haifa , Almutairi Abdulaziz , Nashawi Mohammed , Basahl Emtenan , Abushhaiwia Awatif , Hashad Soad , Etayari Hala , Elfawires Yusra , Khawaja Khulood Walid , Bakry Reima , Akbar Lujayn , De Vol Edward , AlSaleem Alhanouf , Al-Mayouf Sulaiman M 
Published: August 2024

Background Systemic lupus erythematosus (SLE) is a chronic inflammatory multisystemic disease. Monitoring disease activity thoughtout the disease course is important for effective management and assessment of disease outcome. Objective To assess whether the pan-immune inflammation value (PIIV) at diagnosis could predict organ involvement and disease activity in childhood SLE (cSLE) patients after 12 months of disease onst. Methods This is an observational retrospective multicenter study that comprised cSLE patients seen and followed at the participating centers between January 2010 and December 2022. All patients met the EULAR/ACR-19 criteria, were immunosuppressive drug-naïve at the time of SLE diagnosis and had a minimal follow-up period of 12 months. The data included clinical and laboratory findings and disease activity using the SLEDAI-2K. Receiver operating characteristic (ROC) curves were employed to determine the optimal cut-off value of PIIV and assess its predictive potential for disease activity, and organ involvement. Results A total of 125 patients (104 female) with a median age of 16.0 (IQR 5.6) years, a median age at disease onset of 10.9 (IQR 3.0) years, and a median disease duration of 4.8 (IQR 5.3) years were included. The most frequent involved organs at diagnosis were hematological (89.6%), musculoskeletal (68.8%), mucocutaneous (63.2%), and renal (58.4%). However, at a 12-month follow-up visit, the most frequent involved organs were renal (40.0%), hematological (39.2%), musculoskeletal (15.2%), and mucocutaneous (10.4%). The median PIIV at diagnosis was 139 (IQR 229.6), while the median SLEDAI was 12 (IQR 6.5) and 3.5 (IQR 7.0) at diagnosis and 12 months, respectively. An optimal PIIV cut-off of 250 was found to be a predicative for disease activity, with a sensitivity of 45% and a specificity of 86%. The study revealed that the PIIV successfully predicted four systems in our cohort of patients. Conclusion Our work suggests the PIIV might be a reasonable predictor for organ involvement and disease activity in newly diagnosed cSLE, though further research, particularly larger studies, is required to validate these findings, especially regarding organ involvement.
Biomechanical effects of femoral prosthesis misalignment on the structure of the lateral compartment during medial unicompartmental knee arthroplasty in osteoporotic patients
Authors: Liu Mengfei , Jiang Kan , Ju Xiaochen 
Published: August 2024

Background This study aims to investigate the impact of varying coronal alignments of femoral prostheses on stress and strain distributions within the lateral compartment following unicompartmental knee arthroplasty (UKA) in patients with normal bone density and osteoporosis using finite element analysis. Additionally, it examines the relationship between osteoporosis and the progression of osteoarthritis in the lateral compartment postoperatively. Methods UKA models were developed for both normal bone and osteoporotic conditions using a validated finite element model of the knee. Seven alignment conditions for the femoral prosthesis were simulated: 0° (neutral alignment), varus angles of 3°, 6°, and 9°, and valgus angles of 3°, 6°, and 9°, resulting in a total of 14 scenarios. Stress and strain distributions in the meniscus, tibial cartilage, and femoral cartilage of the lateral compartment were evaluated. Results The results indicated that stress and strain in the meniscus, tibial cartilage, and femoral cartilage of the lateral compartment increased with greater varus alignment and decreased with greater valgus alignment in both normal and osteoporotic models. At equivalent alignment angles, stress and strain were consistently higher in the osteoporotic model (M2) compared to the normal bone model (M1), although the peak equivalent stress in the tibial cartilage was lower in the M2 model than in the M1 model. Conclusions In patients with osteoporosis undergoing fixed-bearing medial UKA, varus malalignment of the femoral prosthesis can lead to increased stress and strain in the lateral compartment’s meniscus, tibial cartilage, and femoral cartilage. These findings suggest that osteoporosis may contribute to abnormal stress and strain distributions in the lateral compartment following UKA, potentially accelerating the progression of osteoarthritis in this region postoperatively.
Translating Open-Ended Questions in Cross-Cultural Qualitative Research: A Comprehensive Framework
Authors: de Jesús-Espinosa Tania , Solís-Báez Solymar , Valencia-Molina Claudia P. , Triana Orrego Juan Camilo , Benítez Duque Joas , Phillips J. Craig , Schnall Rebecca , Cuca Yvette P. , Chen Wei-Ti , Shaibu Sheila , Sabone Motshedisi , Wang Tongyao , Iwu Emilia , Horvat Davey Christine , Murphey Christina , Palmieri Patrick , Chaiphibalsarisdi Puangtip , Corless Inge B. , Makhado Lufuno , Santa Maria Diane , Dawson-Rose Carol 
Published: August 2024

Introduction: Globalization has increased the importance of multicultural research to address health disparities and improve healthcare outcomes for underrepresented communities. The International Nursing Network for HIV Research (The Network) serves as a platform for researchers to collaborate on cross-cultural and cross-national HIV studies. This article discusses the Network’s approach to overcoming barriers in multicultural and multinational research in a qualitative context. Methods: The network created a protocol to guide decision-making throughout the translation process of qualitative data collected from participants in their native languages. The protocol includes aspects of why, when, what, who, how, where, and by what means the translation is completed. Results: The protocol has allowed researchers to enhance the validity, reliability, and cultural sensitivity of translation process, ensuring the clarity and impact of their research findings. Discussion: Rigorous translation practices promote cross-cultural understanding and respect for participants’ perspectives, fostering global collaborations and knowledge exchange.