bluuebunny/crossref_metadata_2025_split huggingface dataset:
Retrospective Analysis of Long-Term Outcomes After Combat Injury
Authors: Stewart Ian J. , Sosnov Jonathan A. , Howard Jeffrey T. , Orman Jean A. , Fang Raymond , Morrow Benjamin D. , Zonies David H. , Bollinger Mary , Tuman Caroline , Freedman Brett A. , Chung Kevin K. 
Published: November 2015

Background—
During the conflicts in Iraq and Afghanistan, 52 087 service members have been wounded in combat. The long-term sequelae of these injuries have not been carefully examined. We sought to determine the relation between markers of injury severity and the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease.

Methods and Results—
Retrospective cohort study of critically injured US military personnel wounded in Iraq or Afghanistan from February 1, 2002 to February 1, 2011. Patients were then followed until January 18, 2013. Chronic disease outcomes were assessed by International Classification of Diseases, 9th edition codes and causes of death were confirmed by autopsy. From 6011 admissions, records were excluded because of missing data or if they were for an individual’s second admission. Patients with a disease diagnosis of interest before the injury date were also excluded, yielding a cohort of 3846 subjects for analysis. After adjustment for other factors, each 5-point increment in the injury severity score was associated with a 6%, 13%, 13%, and 15% increase in incidence rates of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease, respectively. Acute kidney injury was associated with a 66% increase in rates of hypertension and nearly 5-fold increase in rates of chronic kidney disease.

Conclusions—
In Iraq and Afghanistan veterans, the severity of combat injury was associated with the subsequent development of hypertension, coronary artery disease, diabetes mellitus, and chronic kidney disease.
Descriptions of two new Species of Goniozus Förster, 1856 (Hymenoptera: Bethylidae) associated with insect induced plant galls from India
Authors: SANTHOSH SHREEVIHAR , RANJITH AVINJIKKATTU PARAMBIL 
Published: November 2015

Two new species of the genus Goniozus viz., Goniozus inauditus Santhosh sp. nov. and G. kuriani Santhosh sp. nov. associated with insect induced plant galls from South India are described. The parasitic relationship of Goniozus with the nonlepidopteran hosts living in the concealed habitats and their association with insect induced plant galls and its inhabitants are reviewed. The possible host range extension of Goniozus is commented.
A Cluster-Based Method for Hydrometeor Classification Using Polarimetric Variables. Part II: Classification
Authors: Wen Guang , Protat Alain , May Peter T. , Moran William , Dixon Michael 
Published: November 2015

AbstractTwo new algorithms for hydrometeor classification using polarimetric radar observations are developed based on prototypes derived by applying clustering techniques (Part I of this two-part paper). Each prototype is defined as a probability distribution of the polarimetric variables and ambient temperature corresponding to a hydrometeor type. The first algorithm is a maximum prototype likelihood classifier that uses all prototypes attributed to the different hydrometeor types in Part I. The hydrometeor type is assigned as the prototype with the highest likelihood when comparing the polarimetric variables and temperature with each prototype. The second algorithm is a Bayesian classifier that uses the probability density functions (PDFs) as derived from the prototype set associated with the identical hydrometeor type. The posteriori probability in the Bayesian method is calculated from a combination of the PDFs and the prior probability, the maximum of which corresponds to the most likely hydrometeor type. The respective merits of the two techniques are discussed. The two classifiers are applied to CP-2 S-band radar observations of two hailstorms that occurred between 16 and 20 November 2008, including the so-called Gap storm, which produced a devastating microburst and large hail at the ground. Results from the classifiers are compared with those derived using the well-established National Center for Atmospheric Research fuzzy logic classifier. In general, good agreement is found, yielding overall confidence in the robustness of the new classifiers. However, large differences are found for the melting ice and ice crystal categories, which will need to be studied further.
A critical review of the effectiveness of environmental assessment and modification in the prevention of falls amongst community dwelling older people
Authors: Pighills Alison , Ballinger Claire , Pickering Ruth , Chari Satyan 
Published: November 2015

Introduction The potential of environmental assessment and modification to reduce falls has recently received attention within the gerontology literature. Research investigating the clinical effectiveness of this intervention in falls prevention reports conflicting results. Discrepancies are due to variation in the risk profile of study participants and the health care background of the person providing the environmental intervention or the intensity of the intervention provided. Method The purpose of this paper is to compare and contrast two systematic reviews, which include meta-analyses, of environmental interventions for falls prevention in community dwelling older people, using the critical appraisal skills programme tool for systematic reviews. Findings Both reviews found that: environmental assessment and modification was effective in falls prevention; intervention was effective with high but not low risk participants; and that high intensity environmental assessment was effective, whereas low intensity intervention was not. Environmental interventions which were delivered by occupational therapists were deemed high intensity, probably because their underpinning theoretical frameworks focus on the impact of the environment on function. Conclusion We discuss possible reasons why occupational therapist led environmental assessment and modification is clinically effective in falls prevention, for people at high risk of falls, whereas non occupational therapist led intervention is not.
Microstructure and in vitro cellular response to novel soy protein-based porous structures for tissue regeneration applications
Authors: Olami Hilla , Zilberman Meital 
Published: November 2015

Interest in the development of new bioresorbable structures for various tissue engineering applications is on the rise. In the current study, we developed and studied novel soy protein-based porous blends as potential new scaffolds for such applications. Soy protein has several advantages over the various types of natural proteins employed for biomedical applications due to its low price, non-animal origin and relatively long storage time and stability. In the present study, blends of soy protein with other polymers (gelatin, pectin and alginate) were added and chemically cross-linked using the cross-linking agents carbodiimide or glyoxal, and the porous structure was obtained through lyophilization. The resulting blend porous structures were characterized using environmental scanning microscopy, and the cytotoxicity of these scaffolds was examined in vitro. The biocompatibility of the scaffolds was also evaluated in vitro by seeding and culturing human fibroblasts on these scaffolds. Cell growth morphology and adhesion were examined histologically. The results show that these blends can be assembled into porous three-dimensional structures by combining chemical cross-linking with freeze-drying. The achieved blend structures combine suitable porosity with a large pore size (100–300 µm). The pore structure in the soy-alginate scaffolds possesses adequate interconnectivity compared to that of the soy-gelatin scaffolds. However, porous structure was not observed for the soy-pectin blend, which presented a different structure with significantly lower porosities than all other groups. The in vitro evaluation of these porous soy blends demonstrated that soy-alginate blends are advantageous over soy-gelatin blends and exhibited adequate cytocompatibility along with better cell infiltration and stability. These soy protein scaffolds may be potentially useful as a cellular/acellular platform for skin regeneration applications.
Psychological distress in corticosteroid-naive patients with systemic lupus erythematosus: A prospective cross-sectional study
Authors: Nishimura K , Omori M , Katsumata Y , Sato E , Kawaguchi Y , Harigai M , Yamanaka H , Ishigooka J 
Published: November 2015

Objective Psychological distress, such as depression and anxiety, has been intensively studied in patients with systemic lupus erythematosus (SLE). However, those studies have mostly included patients who were treated with corticosteroids, which might themselves induce mood disturbances. We investigated psychological distress in corticosteroid-naive patients with SLE who did not exhibit any overt neuropsychiatric manifestations. Methods Forty-three SLE in-patients with no current or past abnormal neuropsychiatric history participated in the study. Patients and 30 healthy control subjects with similar demographic and personality characteristics were administered a comprehensive battery of psychological/neuropsychological tests. The Profile of Mood States (POMS) was used to assess depression and anxiety. Results of clinical, laboratory, and neurological tests were compared with regard to their presence. Results Prevalence of depression was higher in patients ( n = 11, 25.6%) than in controls ( n = 2, 6.7%; p = 0.035), although prevalence of anxiety did not differ across groups (patients: 34.9%, n = 15; controls: 16.7%, n = 5; p = 0.147). Using multiple logistic regression analysis, we identified avoidance coping methods (OR, 1.3; 95% CI 1.030–1.644; p = 0.027) as an independent risk factor for depression. Conclusion Our results indicate that depression presents more frequently in corticosteroid-naive patients with early-stage, active SLE than in the normal population, but anxiety does not. Depression may be related to psychological reactions to suffering from the disease.
Return Migration of Highly Skilled Scientists and Engineers to Morocco: Return or Circulation?
Authors: Gaillard Anne-Marie , Gaillard Jacques 
Published: November 2015

The qualification level of the emigrating Moroccans rose steadily in the 1990s, and especially since the year 2000. At present, an estimated 20 per cent of the highly qualified Moroccans live abroad. Student migration, which accounts for a large part of this 20 per cent, is contributing substantially to keeping this level high. For the last 20 years Morocco has been testing actions to mobilise and reconnect its S&T diaspora. The related special programmes and institutions are discussed and analysed in this article. Results are mixed, especially if measured against the original goals and the high expectations of the MREs (Marocains Résidant à l’Etranger: Moroccans living abroad). In response to these weaknesses and criticisms, proposals for institutional reorganisation and programme revisions have recently been put forth, or tested, but it is too early to evaluate the outcome. Interviews conducted in Morocco and in Europe with scientists who returned to their country or were part of the diaspora living in Europe indicate a very strong desire to participate in the development of Morocco, but also highlight inhibiting factors inherent in the public higher education and research. The international mobility of the interviewees was a constant but not all thought that Morocco would be their final landing place. Many of them are the forerunners in a new type of mobility system that will contribute (together with the reform measures that Morocco will have to adopt) to making the Moroccan national research system attract Moroccan and foreign scientists for all or part of their professional career.
“Angle to Be Corrected” in Preoperative Evaluation for Hallux Valgus Surgery
Authors: Ortiz Cristian , Wagner Pablo , Vela Omar , Fischman Daniel , Cavada Gabriel , Wagner Emilio 
Published: November 2015

Background: The most common methods for assessing severity of hallux valgus deformity and the effects of an operative procedure are the angular measurements in weightbearing radiographs, specifically the hallux valgus angle and intermetatarsal angle (IMA). Our objective was to analyze the interobserver variability in hallux valgus patients of a new angle called the “angle to be corrected” (ATC), and to compare its capacity to differentiate between different deformities against IMA. Methods: We included 28 symptomatic hallux valgus patients with 48 weightbearing foot x-rays. Three trained observers measured the 1 to 2 IMA and the ATC. We then identified retrospectively 45 hallux valgus patients, which were divided into 3 operative technique groups having used the ATC as reference, and analyzed the capacity of the IMA to differentiate between them. Results: The IMA average value was 13.6 degrees, and there was a significant difference between observer 3 and observer 1 ( P = .001). The average value for the ATC was 8.9 degrees, and there was no difference between observers. Both angles showed a high intraclass correlation. Regarding the capacity to differentiate between operative technique groups, the ATC was different between the 3 operative technique groups analyzed, but the IMA showed differences only between 2. Conclusions: The ATC was at least as reliable as the intermetatarsal angle for hallux valgus angular measurements, showing a high intraclass correlation with no interobserver difference. It can be suggested that the ATC was better than the IMA to stratify hallux valgus patients when deciding between different operative treatments. Level of Evidence: Level III, comparative study.
Targeting CD123 in acute myeloid leukemia using a T-cell–directed dual-affinity retargeting platform
Authors: Al-Hussaini Muneera , Rettig Michael P. , Ritchey Julie K. , Karpova Darja , Uy Geoffrey L. , Eissenberg Linda G. , Gao Feng , Eades William C. , Bonvini Ezio , Chichili Gurunadh R. , Moore Paul A. , Johnson Syd , Collins Lynne , DiPersio John F. 
Published: November 2015

Key Points
A novel CD3×CD123 DART agent induces T-cell-target-specific association, activation, and proliferation. The CD3×CD123 DART induces a dose-dependent killing of AML cell lines and primary AML blasts in vitro and in vivo.
Register in the round: registerial cartography
Authors: Matthiessen Christian MIM 
Published: November 2015

AbstractRegisterial cartography is the activity of systematically describing the registers that make up a language — with register in its original sense of a functional variety of a language, i.e. of the adaptation of the meaning-making resources of a language according to context of use. A register map of a language would thus show its composition of registers — of meanings at risk in the various cultural domains that constitute a culture. This variation according to use — register variation — is located along the cline of instantiation between the overall meaning potential of a language operating in the context of culture and the instantiation of this meaning potential unfolding as texts in contexts of situation.In this paper, I will report on a long-term register cartography project concerned with the analysis and description of the registers that collectively constitute the meaning potential of a language. The maps produced as part of the project are based on context in the first instance, since register variation is precisely variation according to context of use. Thus registers can be located within the map according to the “longitude and latitude” of context, i.e. according to the contextual parameters of field, tenor and mode. Here I will focus on a field-based map, more specifically one based on a typology of fields of activity — a characterizations of different goings-on in context. This typology differentiates eight primary types of field of activity, ‘expounding’, ‘reporting’, ‘recreating’, ‘sharing’, ‘doing’, ‘enabling’, ‘recommending’ and ‘exploring’, and their secondary and tertiary subtypes. I will then illustrate how texts operating in contexts characterized by these different fields of activity are organized semantically in terms of logico-semantic (rhetorical) relations (based on a version of RST, Rhetorical Structure Theory), showing that different relations are “at risk” depending on the nature of the field of activity. I will round off the paper by discussing how field-based maps of registers have and can be used in different areas of application.
Postoperative Adjuvant Lapatinib and Concurrent Chemoradiotherapy Followed by Maintenance Lapatinib Monotherapy in High-Risk Patients With Resected Squamous Cell Carcinoma of the Head and Neck: A Phase III, Randomized, Double-Blind, Placebo-Controlled Study
Authors: Harrington Kevin , Temam Stephane , Mehanna Hisham , D'Cruz Anil , Jain Minish , D'Onofrio Ida , Manikhas Georgy , Horvath Zsuzsanna , Sun Yan , Dietzsch Stefan , Dubinsky Pavol , Holeckova Petra , El-Hariry Iman , Franklin Natalie , Biswas-Baldwin Nigel , Legenne Philippe , Wissel Paul , Netherway Thelma , Farrell John , Ellis Catherine , Wang-Silvanto Jing , Amonkar Mayur , Ahmed Nazma , Santillana Sergio , Bourhis Jean 
Published: November 2015

Purpose This multicenter phase III study evaluated the efficacy and safety of lapatinib, an epidermal growth factor receptor/ErbB2 inhibitor, administered concomitantly with chemoradiotherapy and as maintenance monotherapy in patients with high-risk surgically treated squamous cell carcinoma of the head and neck (SCCHN). Patients and Methods Patients with resected stage II to IVA SCCHN, with a surgical margin ≤ 5 mm and/or extracapsular extension, were randomly assigned to chemoradiotherapy (66 Gy total radiation dose and cisplatin 100 mg/m2 per day administered on days 1, 22, and 43) plus placebo or lapatinib (1,500 mg per day) before and during chemoradiotherapy, followed by 12 months of maintenance monotherapy. Results Six hundred eighty-eight patients were enrolled (lapatinib, n = 346; placebo, n = 342). With a median follow-up time of 35.3 months, the study ended early because of the apparent plateauing of disease-free survival (DFS) events. Median DFS assessed by an independent review committee was 53.6 months and not reached for lapatinib and placebo, respectively (hazard ratio, 1.10; 95% CI, 0.85 to 1.43). Investigator-assessed results confirmed the independent review committee assessment. No significant differences in DFS by human papillomavirus status or overall survival were observed between treatment arms. Similar numbers of patients in both treatment arms experienced adverse events (AEs), with more patients in the lapatinib arm than the placebo arm experiencing serious AEs (48% v 40%, respectively). The most commonly observed treatment-related AEs were diarrhea and rash, both predominantly in the lapatinib arm. Conclusion Addition of lapatinib to chemoradiotherapy and its use as long-term maintenance therapy does not offer any efficacy benefits and had additional toxicity compared with placebo in patients with surgically treated high-risk SCCHN.
Molecular Heterogeneity and Response to Neoadjuvant Human Epidermal Growth Factor Receptor 2 Targeting in CALGB 40601, a Randomized Phase III Trial of Paclitaxel Plus Trastuzumab With or Without Lapatinib
Authors: Carey Lisa A. , Berry Donald A. , Cirrincione Constance T. , Barry William T. , Pitcher Brandelyn N. , Harris Lyndsay N. , Ollila David W. , Krop Ian E. , Henry Norah Lynn , Weckstein Douglas J. , Anders Carey K. , Singh Baljit , Hoadley Katherine A. , Iglesia Michael , Cheang Maggie Chon U. , Perou Charles M. , Winer Eric P. , Hudis Clifford A. 
Published: November 2015

Purpose Dual human epidermal growth factor receptor 2 (HER2) targeting can increase pathologic complete response rates (pCRs) to neoadjuvant therapy and improve progression-free survival in metastatic disease. CALGB 40601 examined the impact of dual HER2 blockade consisting of trastuzumab and lapatinib added to paclitaxel, considering tumor and microenvironment molecular features. Patients and Methods Patients with stage II to III HER2-positive breast cancer underwent tumor biopsy followed by random assignment to paclitaxel plus trastuzumab alone (TH) or with the addition of lapatinib (THL) for 16 weeks before surgery. An investigational arm of paclitaxel plus lapatinib (TL) was closed early. The primary end point was pCR in the breast; correlative end points focused on molecular features identified by gene expression–based assays. Results Among 305 randomly assigned patients (THL, n = 118; TH, n = 120; TL, n = 67), the pCR rate was 56% (95% CI, 47% to 65%) with THL and 46% (95% CI, 37% to 55%) with TH (P = .13), with no effect of dual therapy in the hormone receptor–positive subset but a significant increase in pCR with dual therapy in those with hormone receptor–negative disease (P = .01). The tumors were molecularly heterogeneous by gene expression analysis using mRNA sequencing (mRNAseq). pCR rates significantly differed by intrinsic subtype (HER2 enriched, 70%; luminal A, 34%; luminal B, 36%; P < .001). In multivariable analysis treatment arm, intrinsic subtype, HER2 amplicon gene expression, p53 mutation signature, and immune cell signatures were independently associated with pCR. Post-treatment residual disease was largely luminal A (69%). Conclusion pCR to dual HER2-targeted therapy was not significantly higher than single HER2 targeting. Tissue analysis demonstrated a high degree of intertumoral heterogeneity with respect to both tumor genomics and tumor microenvironment that significantly affected pCR rates. These factors should be considered when interpreting and designing trials in HER2-positive disease.