bluuebunny/crossref_metadata_2025_split huggingface dataset:
Microbiological Investigations for Chikungunya Virus in Children With Acute Encephalitis Syndrome in a Non‐Outbreak Setting in Southern India
Authors: Damodar Tina , Pattabiraman Chitra , Singh Bhagteshwar , Jose Maria , Prabhu Namratha , L Akhila , Prasad Pramada , Kinhal Uddhava V. , Lalitha A. V. , Dsouza Fulton Sebastian , Sajjan Sushma Veeranna , Gowda Vykuntaraju K. , Ravi Vasanthapuram , Kolamunnage‐Dona Ruwanthi , Michael Benedict D. , Solomon Tom , Yadav Ravi , Turtle Lance 
Published: February 2025

ABSTRACTChikungunya virus (CHIKV) is an emerging cause of acute encephalitis syndrome (AES) in India, with limited data on its role in childhood AES in southern India. We systematically evaluated children with AES in southern India during a non‐epidemic period for CHIKV. Serum and cerebrospinal fluid (CSF) samples were tested for CHIKV using IgM ELISA and real‐time reverse transcriptase PCR. Amplicon sequencing was performed on PCR‐positive samples. Clinical and laboratory features were compared between children with and without CSF CHIKV positivity (PCR/IgM antibodies). Of 376 children with AES, 20 (5.3%) had positive CHIKV tests. Co‐infections were common, particularly with scrub typhus. Children presented with diverse symptoms affecting various organ systems. Neurological manifestations included meningism, seizures, cerebellar signs, behavioral abnormalities, cranial nerve involvement, involuntary movements, and hemiparesis/hemiplegia. Children with CSF CHIKV positivity showed more focal neurological deficits and transaminitis, and less musculoskeletal symptoms. Sequencing confirmation of CHIKV was made in all patients with positive CHIKV PCR, revealing a close relationship with 2016 Kenyan and Indian strains, albeit in a different clade within the East/Central/South African genotype. Along with important mutations known to impact CHIKV infectivity, four novel amino acid substitutions were detected in envelope protein coding regions. Our findings underscore the importance of routine and comprehensive CHIKV testing for children with AES, irrespective of season/outbreak. The high rate of co‐infections warrants further research. Continued genomic surveillance is essential to monitor emerging mutations with epidemic potential, increased severity and the risk of neurological disease.
Inhibition of Polo‐Like Kinase 1 Dampens the Replication of Vaccinia Virus in Mammalian Cells
Authors: Zhu Junda , Jia Xuejiao , Ren Shuning , Zhang Zihui , Li Hua , Wang Jing , Song Baifen , Wu Wenxue , Peng Chen 
Published: February 2025

ABSTRACTSince the eradication of smallpox, zoonotic poxviruses, such as the mpox virus (MPXV), continue to pose a threat to public health. Identifying drugs that reduce poxvirus infection and replication, as well as understanding their molecular mechanisms, is essential for epidemic control. Polo‐like kinase 1 (PLK1) has been shown to facilitate vaccinia virus (VACV) infection and replication. This study confirms the effects of the PLK1 inhibitors HMN‐214 and ON‐01910 on VACV replication in A549 cells. Both viral titers and DNA loads were significantly reduced in treated cells after infection. Additionally, ON‐01910 demonstrated broad‐spectrum antiviral activity against the lumpy skin disease virus (LSDV) and the infectious bovine rhinotracheitis virus (IBRV) in vitro. PLK1 knockdown in A549 cells also led to a reduction in VACV protein expression, viral titers, and DNA levels. Further analysis showed that VACV infection leads to the accumulation of PLK1 near viral factories. However, despite its strong in vitro effects, ON‐01910 did not significantly reduce VACV replication in mice. These findings highlight the critical role of PLK1 in VACV replication and its potential as a target for antiviral therapy against orthopoxviruses.
Hypoglossal Nerve Stimulation for Obstructive Sleep Apnea and Comorbid Neuromuscular Disorders
Authors: Choi Alison Y. , Kaffenberger Thomas M. , Soose Ryan J. , Whelan Rachel L. 
Published: February 2025

Hypoglossal nerve stimulation (HGNS) is an effective surgical treatment for many patients with moderate‐to‐severe obstructive sleep apnea (OSA) who are unable to tolerate continuous positive airway pressure. Patients with neuromuscular disorders (NMD) are particularly vulnerable to more complex sleep‐related breathing disorders due to respiratory muscle weakness and the associated risk of hypoventilation.In this study, we present five patients with myasthenia gravis (n = 2), muscular dystrophy, Charcot‐Marie‐Tooth, and advanced multiple sclerosis who underwent HGNS therapy for OSA.At time of surgery, the mean patient age was 54 ± 18.7 years and mean BMI was 24.6 ± 4.6 kg/m2. Mean device adherence was 8 ± 1.1 h/night at three months and 7.2 ± 1.7 h/night at 12 months. Mean apnea‐hypopnea index (AHI) improved significantly from preoperative baseline (34.9 to 8.5, p = 0.03) and 5/6 patients had a postoperative AHI <5. Epworth Sleepiness Scale scores significantly improved postoperatively (13.1–8.5, p = 0.03). Oxygen nadir trended upward (75.5–85.3, p = 0.84).Our limited findings demonstrate that HGNS was a safe and effective treatment for five patients with OSA and comorbid NMD. Prospective studies and larger sample sizes are warranted to support our findings and confirm whether HGNS is a potential therapeutic option for this unique patient population. Laryngoscope, 2025
Can Brand Activism Benefit Luxury Brands?
Authors: Khalifa Dina , Osburg Victoria‐Sophie 
Published: February 2025

ABSTRACTBrands are increasingly taking an active stance on divisive socio‐political issues such as racial justice, transgender rights, gun control, and international conflicts (e.g., the Ukraine‐Russia war). Due to its polarizing nature, brand activism can be a risky strategy, and it is not yet understood how consumers react to brand activism conducted by luxury firms. We propose that activism by luxury brands can act as a novel form of marketing communication that leads to favorable brand outcomes. In four studies (and one pre‐test), we demonstrate the positive effect of luxury activism on consumer purchase intentions and brand evaluations. The effect, to an important extent, is driven by self‐expressive value perception, which enhances the brand's luxury perception, resulting in enhanced purchase intentions. We validate the proposed framework by examining various activism topics (the Ukraine‐Russia war, abortion rights, the “Black Lives Matter” movement). The findings further demonstrate that the effect of brand activism is contingent upon consumer political identity. Specifically, this effect holds for liberal consumers but not for conservative consumers due to the symbolic benefits the former derive from activism, which can manifest in higher purchase intentions.
When to Showcase Automated Production Processes? Disclosing Production Processes Increases Evaluation of Low‐End but Decreases Evaluation of High‐End Products
Authors: Liu Diyi , Qi Suntong , Dai Xianchi , Du Huibin 
Published: February 2025

ABSTRACTIn this information age, consumers can easily learn about the production process for thousands of products, ranging from low‐end options like budget‐friendly pasta and candy to high‐end alternatives, such as gourmet versions of those same items. Despite the increasing prevalence of marketing practices that display automated production processes (e.g., plant tours, online videos, ads, showcases), there is little research on the effect of this practice. We found that it is not always beneficial for consumers to know that a product is produced through automated manufacturing, contrary to what many managers may expect. This paper explores when and why marketers should disclose automated production processes to consumers. Specifically, we found that disclosing automated production process may have opposite effects based on the product's positioning. Through a preliminary survey, two pilot studies, and eight studies, we found that disclosing the automated production process enhances the evaluation of low‐end products by increasing perceived product function, while it negatively impacts the evaluation of high‐end products by reducing perceived product image. We further examined the boundary conditions for the proposed effect. Notably, the negative impact on high‐end products is not observed when the production process is emphasized as handmade (rather than automation), when the product's country of origin is highlighted, or when the product involves advanced technology. Our findings draw attention to the downsides of the automation process. Additionally, this research helps companies to manage the communication of production methods to consumers strategically.
Long‐Term Clinical Outcomes of Treatments for In‐Stent Chronic Total Occlusions: A Real‐World Study Based on Different Strategies of Revascularization
Authors: Yang Zhuoran , Yin Jiasheng , Hu Yiqing , Zhu Li , Zhou You , Zhang Yaqi , Krishnamurthi Nirupama , Jiang Jieyu , Zhou Wenxian , Barman Nitin , Lu Hao , Ge Junbo 
Published: February 2025

ABSTRACTCoronary artery disease (CAD), the most common panvascular disease, can progress to chronic total occlusion (CTO). Drug‐eluting stent (DES) is one of standard CAD treatments, but in‐stent restenosis leading to CTO is challenging, with unclear optimal management. The efficacy of drug‐coated balloons (DCB) for treating DES‐related in‐stent chronic total occlusion (IS‐CTO) is undetermined. In this single‐center retrospective cohort study of 198 patients with IS‐CTO post‐DES, 3‐year outcomes of DCB, DES, and plain old balloon angioplasty (POBA) were compared, focusing on target vessel failure (TVF). DES showed the lowest TVF rate (DCB vs. DES vs. POBA: 31.8% vs. 17.1% vs. 51.6%, p < 0.01), mainly due to fewer revascularizations. Notably, the difference in TVF between DCB and DES became more apparent after the first year. DCB was an independent risk factor for late TVF (HRadj = 6.51, 95% confidence interval [CI] = 2.45–18.84, p < 0.01), whereas POBA for early TVF compared to DCB (HRadj = 5.01, 95% CI = 1.36–18.42, p = 0.02). While POBA‐treated patients exhibited a higher target vessel myocardial infarction rate, the death rates were comparable across all cohorts. In conclusion, DES showed the lowest 3‐year TVF rate, making it the most effective treatment for IS‐CTO compared to DCB and POBA.
The Roles of Fasciotomy and Peripheral Nerve Decompression in Electric Burn Patients: A Systematic Review and Meta‐Analysis
Authors: Blears E. E. , Ballou J. , Weitzner A. , Caffrey Julie , Dellon A. L. 
Published: February 2025

ABSTRACTIntroductionPeripheral nerves preferentially conduct electricity due to their low resistance as compared with other tissues, predisposing them to injury from electrical burns. The purpose of this study was to investigate the efficacy of fasciotomy and peripheral nerve decompression on peripheral nerves after electric injury.MethodsA systematic review of patients who had sustained electric burn injuries was performed according to PRISMA Guidelines. Incidence, demographic and injury characteristics, and patterns of symptoms were analyzed. Meta‐analysis was performed to examine changes from baseline from nerve conduction studies. Outcomes for fasciotomy and various nerve decompressions were also analyzed.ResultsOf the 119 articles included in for systematic review, 16,773 patients were included. Most available studies the case reports or case series that yielded moderate‐ to poor‐quality evidence. The median follow‐up of the included patients was 44 weeks (IQR 15–97 weeks). Patients who underwent fasciotomy had significantly lower rates of peripheral neuropathy than those who did not by the last recorded follow‐up (45% vs. 92%, p < 0.0001). Patients who underwent peripheral nerve decompression after 30 days of injury had lower rates of peripheral neuropathy at the last follow‐up compared with those who underwent decompression within 30 days (21% vs. 53%, p < 0.0001).ConclusionsA paucity of high‐quality evidence exists to standardize management recommendations for peripheral nerve injury; however, of what literature does exist, it seems that fasciotomy and nerve decompressions are associated with improved peripheral nerve function in the long‐term, but nerve decompression likely provides more benefit when performed if symptoms persist one‐year post‐injury.
Key Determinants of Cardiovascular Outcomes in Multi‐Ethnic Patients With Rheumatic Disease Using JAK Inhibitors
Authors: Sunmboye Kehinde , Memon Ahsan , Durrani Maumer 
Published: February 2025

ABSTRACTBackgroundJanus kinase (JAK) inhibitors are effective therapies for autoimmune rheumatic diseases (ARDs), but concerns persist regarding their cardiovascular effects, particularly in diverse patient populations. Identifying determinants of cardiovascular risk is essential for optimising therapy and outcomes, especially in multi‐ethnic cohorts.ObjectiveTo assess clinical and socioeconomic determinants, including age, deprivation decile and ethnicity, in predicting cardiovascular events among patients on JAK inhibitors in a multi‐ethnic cohort.MethodsA retrospective cohort study of 309 patients with ARDs (mean age 59.3 years, 77% female, 73% White, 25% South Asian) receiving JAK inhibitors at a UK teaching hospital was conducted. Cardiovascular events, including myocardial infarctions, strokes and cardiovascular‐related deaths, were recorded. Multivariate logistic regression assessed associations between age, deprivation decile, ethnicity and cardiovascular outcomes.ResultsThe combined effect of age and deprivation decile significantly predicted cardiovascular events (p = 0.031). Older age demonstrated an odds ratio (OR) of 1.06 (95% CI: 1.00–1.13). Neither age nor deprivation decile alone achieved statistical significance, but their combination provided a robust model with an AUC of 0.837. Ethnicity was not independently predictive in this cohort.ConclusionsIn a multi‐ethnic cohort, age and deprivation decile jointly predict cardiovascular events in patients on JAK inhibitors. Socioeconomic factors should be integrated into cardiovascular risk assessment models to inform personalised care strategies for patients receiving JAK inhibitor therapy.
Quality of Life With Ehlers‐Danlos Syndrome/Joint Hypermobility Syndrome: A Systematic Review of Psychosocial Interventions
Authors: Bohling‐Davis Erika , Khan‐Lodhi Boushra , Jenkinson Elizabeth , Tremblett Maddie , Meyrick Jane 
Published: February 2025

ABSTRACTBackgroundPsychosocial interventions may improve QoL in people with wider chronic pain conditions. However, the evidence requires refining for application to EDS/JHMS. This systematic review aimed to identify, assess and synthesise the evidence of the effectiveness of psychosocial interventions concerning EDS/JHMS. EBSCO, OpenGrey, Cochrane, Prospero, Researchgate and BPS Wiley online were searched for papers published approximately 2000–2024 for studies in which (1) Participants diagnosed with EDS/JHMS. (2) Quantitative or mixed methods. (3) Assessed a Psychosocial intervention to a (4) quality of life outcome. (5) in English. EPHPP quality assessment tool was used to assess the quality and risk of bias.Main textThe study identified six studies, including 343 participants aged 13–69 (F = 248, M = 8), of unknown ethnicity. Five studies were cohort and one non‐randomised controlled trial. Key methodological flaws included no reported effect size and no control group. With quality assessed as low (5) or moderate (1), there was weak evidence that psychosocial interventions containing mindfulness and CBT resulted in a general improvement in QoL compared to no intervention.ConclusionsFindings from this review indicate the potential of mindfulness and CBT in improving QOL in EDS/JHMS and, in some studies, pain and fatigue. However, existing research is at high risk of bias, has low methodological quality, and is predominately focused on female patients. Future research should adopt methodologically robust approaches such as RCTs and more inclusive samples and consider co‐production.
Decolonizing Public Administration in Latin America: A Systematic Literature Review of Trending Discussions in the Region
Authors: Didier Nicolas 
Published: February 2025

ABSTRACTThis study examines knowledge production and dissemination dynamics within Latin American Public Administration (PA) as reflected in SCIELO‐indexed journals. By applying a systematic review under PRISMA guidelines, it identifies thematic trends and institutional challenges shaping the regional epistemic community. The findings highlight systemic gaps, including limited journal specialization and underrepresentation of regional voices within the global PA discourse. The study emphasizes theoretical and methodological contributions addressing civil service reforms, PA education, and institutional development while critiquing the pervasive influence of epistemic colonialism. By proposing strategies to integrate local and global perspectives, this work advances the decolonization of PA, fostering inclusive and contextually relevant paradigms. These insights aim to enhance Latin American contributions to global PA debates, bridging disciplinary divides and addressing regional priorities.
Exploring values, rules, and knowledge around traditional hunting in a rapidly developing society
Authors: Plieninger Tobias , Bogadóttir Ragnheiður , Fagerholm Nora , Magnussen Eyðfinn , Olafsson Anton S. , Raymond Christopher M. , Verbrugge Laura N. H. 
Published: February 2025

Abstract

Consideration of traditional practices of natural resource management in decision‐making is crucial to meet the challenges of the world’s intersecting sustainability crises. However, knowledge of the role that such practices play in developed societies is scant, especially in Europe.

This study investigates the persistence of traditional hunting practices in the context of the Faroe Islands. Specifically, it explores the values, rules, and knowledge in relation to traditional hunting practices that shape human–nature relationships.

Through 31 semi‐structured interviews with active participants in mountain hare hunting, pilot whale hunting, and fulmar fowling, the study employs thematic content analysis to identify key themes and interrelations grounded in participant perspectives. Utilising the values‐rules‐knowledge (v‐r‐k) framework, which integrates diverse values, rules, and knowledge types, the study addresses the complex social‐ecological challenges in the North Atlantic. These are characterized by rapid economic growth, geographic isolation, strong place attachment, and social‐ecological vulnerabilities.

Our results show that while traditional practices are diminishing across Europe, they remain vibrant in the Faroe Islands. Yet, hunting has shifted from subsistence to a recreational activity, with relational values to nature and the local community becoming more important than instrumental values.

Our study demonstrates the important influence of the transmission of specific values, rules, and knowledge over time on hunting and ecosystem management practices, which extends existing scholarship on the motivational basis of hunting.

Read the free Plain Language Summary for this article on the Journal blog.
Effect of plating thickness on PA6/nickel‐plated carbon fiber composites manufactured using LFT pellets
Authors: Park Jong‐Hyun , Cho Chaewook , Kim Ki Hoon , Kang Ji‐Hun , Seo Min‐Kang , Choi Bo‐Kyung , Kim Seong Yun 
Published: February 2025

AbstractIn this study, polyamide 6 (PA6)/metal (Ni)‐plated carbon fiber (MCF) long‐fiber‐reinforced thermoplastic (LFT) composites using LFT pellets were fabricated and the variation in their mechanical, thermal, and electrical properties with plating thickness was examined. The plating thickness of MCF significantly influences the physical and mechanical properties, including electrical resistance, mechanical strength, and thermal stability, of MCF LFT composites. PA6/MCF(90), the composite with a moderate plating thickness, exhibits optimal physical properties. Especially, some properties are adversely affected on increasing the plating thickness, possibly, because the properties of MCF LFT composites are influenced by several factors, including fiber–matrix adhesion and plating uniformity. The results of this study could facilitate future studies of high‐performance MCF LFT composites with tuned properties for specific applications.Highlights
CFs coated with 90, 185, and 280 nm Ni thickness were investigated.
Mechanical and EMI properties of composites were determined by Ni thickness.
90 nm Ni coating induced the optimal composite properties.
Bio‐based thermoplastic composites reinforced with natural fillers for sustainable packaging: A comprehensive review
Authors: Moutinho Lisete Garrido , Soares Eduardo , Oliveira Martinho 
Published: February 2025

AbstractPackaging represents a huge field of application for plastic materials, especially for food and beverage purposes. For many years, conventional plastics have been manufactured and used for packaging applications in different sectors. However, plastics based on fossil resources are not biodegradable, which has led to serious environmental issues and recycling problems. In the last years, bio‐based and biodegradable polymers are gaining popularity, emerging as a substitute strategy for some industrial applications to reduce the risk associated with fossil‐based plastics. In this field, biocomposites consisting of bio‐based thermoplastics and natural fillers are gaining traction and increasing interest and investment from industries seeking sustainable solutions to meet consumer demands. In this review, recent advances in the use and characterization of biopolymers and biocomposites, and their potential as a packaging material are addressed. Legal regulation for packaging applications in Europe and United States of America are explored and its enforcement for biocomposite materials is discussed. This work provides relevant information of biocomposites performance for packaging applications, market perspective and legal compliance.Highlights
Global plastic production achieved a total of 400.3 M tons in 2022.
Packaging is the main application for plastics which is an environmental issue.
Biocomposites are a sustainable alternative for packaging.
Natural fillers improve relevant properties for biocomposite packaging materials.
Legal aspects regarding biocomposites for food packaging is explored.
Failure prediction analysis‐based mechanostructural design of ply overlap joint for conformal load‐bearing antenna structure
Authors: Jeon Jae‐An , Park Ill‐Kyung , Lee Sang Eui 
Published: February 2025

AbstractPly overlap joint designs were investigated in the mechanostructural point of view to secure the mechanical performance of an electromagnetic (EM) window of conformal load‐bearing antenna structures (CLAS). The EM window was constructed with a combination of dissimilar materials of carbon‐fiber (CF) fabrics and glass‐fiber (GF) fabrics. Three types of ply overlap joints laminated in [0/45/−45/0] stacking sequence for each CF and GF fabric were considered: staggered overlap, flush overlap, and hybrid overlap. Evaluation and analysis of each ply overlap joint design was performed through tensile testing and finite element analysis. The tensile tests revealed that the staggered overlap, the hybrid overlap, and the flush overlap have the higher joint strength in order, and that the increase in the overlap length accompanied the increase in the joint strength for the staggered joint and the hybrid one. Finite element analysis with a cohesive zone model that mimics interlaminar behavior and a progressive damage model that imitates a failure behavior was able to accurately predict the fracture behavior observed in the experiment. This study can provide a deeper understanding of the structural behavior of ply overlap joints for CLAS.Highlights
CLAS offers load‐bearing and antenna functions, replacing protruding antennas.
Ply overlap joint can be an effective design for the structural performance of CLAS.
Staggered overlap showed the highest structural performance in tensile loading mode.
FE analysis using the cohesive zone model was in good agreement with the experiment.