bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebriform Intradermal Nevus: A Case of Scalp Expansion on the Galea
Authors: Hashimoto Ichiro , Urano Yoshio , Nakanishi Hideki , Oura Hajimu , Kato Shoji , Arase Seiji 
Published: April 2015

AbstractWe report here a 7‐year‐old Japanese girl with cerebriform intradermal nevus (CIN). By placement of expanders on the galea, her scalp was expanded more easily with less discomfort than is expected when the expanders are placed under the galea. An immunohis‐tochemical study on the expression of proliferating cell nuclear antigen suggested higher proliferative activity of nevus cells from the CIN lesion than that of cells from congenital or acquired intradermal nevi. The high proliferative activity appeared to be associated with a growth spurt of the lesion.
Identification of Several Clinical Isolates of Dermatophytes Based on the Nucleotide Sequence of Internal Transcribed Spacer 1 (ITS 1) in Nuclear Ribosomal DNA
Authors: Mochizuki Takashi , Kawasaki Masako , Ishizaki Hiroshi , Makimura Koichi 
Published: April 2015

AbstractNucleotide sequences of internal transcribed spacer 1 (ITS 1) in nuclear ribosomal DNA from seven morphlogically unidentified dermatophyte isolates were determined. The sequences were compared with those of typical isolates of Trichophyton (T.) mentagrophytes var. interdigitale, T. rubrum, and Epidermophyton floccosum. Two of the isolates were classified as T. rubrum and the other five as T. mentagrophytes var. interdigitale. The results did not conflict with identifications using other molecular techniques, including random amplification of polymorphic DNA (RAPD) analysis and restriction enzyme analysis of mitochondrial DNAs. Thus, the nuclotide sequence of ITS 1 is possibly a good molecular marker for identification of these major anthropophilic dermatophyte species.
Clinico‐Bacteriological Study of Pyodermas in Children
Authors: Kakar Nirupama , Kumar Vijay , Mehta Geeta , Sharma Ravi C. , Koranne Ravindra V. 
Published: April 2015

AbstractOne hundred cases of pyodermas in children were investigated clinically and bacteriologically. Nasal and throat swabs from all cases were subjected to bacteriological examination. Most of the children (42%) were in the 1–4 year age group. The majority (58%) belonged to lower socio‐economic groups with poor standards of hygiene. A history of overcrowding was obtained from 87% of cases, 82% were undernourished. Most of the children (68%) reported during the hot and humid months of June, July, August, and September. Primary pyodermas were observed in 72% of the children, and secondary pyodermas in 28%. Impetigo was the commonest primary pyoderma (48.61%); among secondary pyodermas, infected scabies was noted predominantly (42.86%). The face and legs were more commonly involved.Bacteriological cultures from pyoderma lesions revealed a single microorganism in the majority of the patients (84%). Staphylococcus aureus was isolated in pure culture from 48% and pure beta‐hemolytic streptococci from 36%. A combination of both was obtained from 16%. No other organism was isolated from any case. A similar pattern was also observed in cultures from the nose and throat. Only 46 out of the 64 strains (84.3%) of Staphylococcus aureus isolated from pyoderma were typable. The majority (39.1 %) showed a mixed pattern of phages; the second commonest was the non‐allocated phage type (30.4%). Nasal flora had more of the non‐allocated phage type (50%); two out of the three strains (66.6%) isolated from the throat showed a mixed pattern. All the strains of beta hemolytic streptococci, isolated either from lesions of pyoderma, nose, or throat belonged to group A. Staphylococcus aureus and showed a high sensitivity to netilmycin (100%), ofloxacin (98.4%), amoxycillin/clavulanic acid (96.9%), ciprofloxacin (89.1%) and gentamycin (84.4%) but a high resistance to penicillin (85.9%). A greater correlation was noted between nasal flora and organisms causing pyodermas.A change in the pattern of organisms causing pyodermas in children and their antibioic sensitivities in this part of the globe has been observed in this study. The role of endogenous nasal and throat flora in the causation of pyodermas has also been highlighted.
The Spectrum of Mucocutaneous Manifestations during the Evolutionary Phases of HIV Disease: An Emerging Indian Scenario
Authors: Singh Ajit , Thappa Devinder Mohan , Hamide Abdoul 
Published: April 2015

AbstractThird world countries, including India, lack sophisticated investigations to assess the progression of HIV disease. Hence, this study was undertaken to determine the clinical mucocutaneous markers of HIV disease and to establish its relationship with the stage of the disease. This was an observational institutional study of 75 patients with mucocutaneous disorders and HIV infection recruited over a period extending from September of 1996 to June of 1998. The patients with mucocutaneous lesions were staged according to the Centers for Disease Control classification system for HIV infection (1986). The most frequent mode of acquisition of HIV infection was heterosexual contact (96%). The patients were broadly categorized into two groups. The AIDS group was comprised of patients who were in group IV and the early HIV infection group included patients in group II and III; none were detected in group I. Forty‐eight cases belonged to the AIDS group, and 27 belonged to the early HIV infection group. A total of 207 dermatoses were diagnosed and grouped as fungal, viral, bacterial, or miscellaneous. The common mucocutaneous disorders in order of frequency observed in this study were: candidiasis, dermatophytosis, herpes simplex, oral aphthae, xerosis/ichthyosis, scabies, HPV infection, molluscum contagiosum, and psoriasis. Xerosis/acquired ichthyosis and giant molluscum contagiosum were characteristically seen in group IV of HIV disease, whereas oral candidiasis, oral aphthae, papular dermatitis of HIV, and psoriasis were early warning signs. The mean number of dermatoses per patient in group IV was 3.15; in group III, it was 2.41; and in group II, it was 1.5. There was a statistically significant difference between the early HIV infection group and AIDS group with regard to number of dermatoses. Apart from syphilis and human papilloma virus infection, the treatment outcomes were satisfactory.
Macular Amyloidosis: Etiological Factors
Authors: Eswaramoorthy V. , Kaur Inderjeet , Das Ashim , Kumar Bhushan 
Published: April 2015

AbstractMacular amyloidosis is the commonest form of primary localized cutaneous amyloidosis; its etiology remains unclear. Various incriminating factors include genetics, sunlight, and fricition. Seventy‐five patients with a clinical diagnosis of macular amyloidosis (confirmed by at least two observers) were enrolled in the study. A detailed history was elicited in relation to the etiological factors and followed by cutaneous examination. Skin biopsy was performed in 44 patients. Amyloid deposits were demonstrated in 21 (48%) of the biopsies. The female to male ratio was over 3:1. Patients with skin type V had a more delayed onset than those with skin types III and IV. Two patients gave histories of regularly subjecting their skin to friction. There was no correlation between the sites affected and the sites subjected to friction, hair style of the patient, or the use of cosmetics. Family history was present in 7 (9.3%) patients. A majority, 44 (58.7%) of the patients, had involvement of both sun‐exposed and sun‐protected sites. To conclude, there was no direct correlation between macular amyloidosis and atopy, sunlight, or friction to the skin in our patients. Multiple factors may play a collective role in the genesis of macular amyloidosis to variable degrees. These include racial, familial, and environmental factors, atopy, sunlight, friction, and female gender.
Progeria (Hutchinson‐Gilford): A Case Report
Authors: Sivaraman Devinder Mohan Thappa , D'Souza Mariette , Ratnakar Chagantt 
Published: April 2015

AbstractA new case with the typical features of progeria (Hutchinson‐Gilford) occurred in India. Histopathology of the skin showed atrophic epidermis and diffuse fibrosis of dermis with loss of appendages. Roentgenographic findings were characteristic of progeria. The child also had a gangrenous ulcer over the left foot, a finding not highlighted in the literature.
Aggregated Dilated Pores
Authors: Konohana Akira , Kobayashi Takashi 
Published: April 2015

AbstractWe report a 74‐year‐old Japanese man who had a 10‐year history of approximately 20 open comedones crowded onto his lateral neck. An excisional biopsy revealed that each comedo was histologically a dilated pore. Dilated pores are usually solitary. The multiple and aggregated dilated pores seen in our case have never been reported.
Evaluation of Thyroid Function in North Indians with Alopecia Areata: Response to Intravenous Injection of 100 μg Thyrotropin Releasing Hormone (TRH)
Authors: Sharma Vinod K , Sialy Ravinder , Kumar Bhushan , Gupta Somesh 
Published: April 2015

AbstractThere is a lack of agreement on the overall prevalence of thyroid disease and thyroid function abnormalities in alopecia areata. Only one study is available from the Indian subcontinent. All patients with alopecia areata attending a dermatology outpatient clinic between 1983 and 1997 were screened for the presence of clinical thyroid disease. Sixty‐two consecutive patients during the year 1994 were evaluated in detail for thyroid functions by measuring T3, T4, TSH levels and testing for antithyroid and antimicrosomal antibodies. Twenty‐two patients randomly selected from the above‐mentioned sixty two were studied for TSH response to intravenous injection of 100 μg TRH at ‐20, 0 and 20, 60, and 120 minutes after TRH injection. Thyroid disease was clinically evident in 16 (0.85%) of the 1700 patients with alopecia areata seen over the last fifteen years. All sixty‐two patients evaluated for thyroid functions were clinically euthyroid. Seven (11.3%) out of these 62 patients had abnormal thyroid hormone levels. Antithyroid and antimicrosomal antibodies were found in five patients; all five had abnormalities in thyroid function. TSH response to TRH was suggestive of hypothyroidism in 4 (18%) of the 22 patients studied. Manifest thyroid disease is infrequently associated with alopecia areata. Abnormalities in thyroid functional status were more frequent; they were found in 7 (11.3%) out of 62 patients. TSH response to intravenous TRH was abnormal in an even higher proportion [4 (18%) out of 22 patients]. There was no apparent correlation with duration or type of alopecia areata.
Paraneoplastic Syndromes of Leukocytosis, Thrombocytosis, and Hypercalcemia Associated with Squamous Cell Carcinoma
Authors: Kato Naoko , Yasukawa Kana , Onozuka Takashi , Kimura Kumiko 
Published: April 2015

AbstractParaneoplastic syndromes including leukocytosis, thrombocytosis and hypercalcemia are occasionally seen in patients suffering from progressive malignant disorders. Recent studies have revealed the production of several humoral factors by tumor cells and normal splenic cells of tumor‐bearing patients to be the major cause of these reactions. Granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), granulocyte‐colony stimulating factor (G‐CSF), parathyroid hormone‐related peptide, interleukin (IL)‐1, IL‐6, and tumor necrosis factor (TNF) have been implicated.We describe a 58‐year‐old Japanese man with squamous cell carcinoma (SCC) on the left sole, which developed in a deep linear scar after a train crash. He developed pulmonary and lymph node metastases, then leukocytosis (57,110/mm3 with 95% neutrophilia), thrombocytosis (86.3 × 104/mm3), and hypercalcemia (7.0 mEq/1), and finally cachexia, followed by death. Serum G‐CSF, IL‐1α, IL‐1β, and TNF‐β were determined; revealing G‐CSF and IL‐1β levels were above the upper limits of their normal ranges at 39.2 pg/ml and 4.63 pg/ml, respectively. It is probable that these humoral factors were partially responsible for the paraneoplastic syndromes induced by the cutaneous SCC with metastasis in the present case.
Pentazocine Induced Widespread Cutaneous and Myo‐Fibrosis
Authors: Jain Annu , Bhattacharya Sambit Narh , Singal Archana , Baruah Manik Chandra , Bhatia Arati 
Published: April 2015

AbstractWe report a case of extensive subcutaneous and muscle fibrosis in a 26‐year‐old Indian woman caused by repeated intramuscular pentazocine injections over five years to highlight the extent and sequelae of this avoidable condition.
Kaposi's Varicelliform Eruptions during the Course of Steroid Withdrawal in a Senile Erythroderma Patient: Cure of Regional Erythrodermic Lesions Following Infection
Authors: Horiuchi Yasuhiro 
Published: April 2015

AbstractThe author encountered a case of Kaposi's varicelliform eruptions on both axillar regions during the course of steroid withdrawal in a 68‐year‐old male with eythroderma following eczema. Immnohistochemical study gave positive indication of herpes simplex virus type I in epidermal keratinocytes in lesional vesicles. Following cure of the varicelliform eruptions, erythrodermic lesions in the axillar regions cleared up completely. For those at other sites, considerably more time was required for cure, with steroid withdrawal being a factor of this period.
Histiocytic Necrotizing Lymphadenitis (Kikuchi's Disease): The Necrotic Appearance of the Lymph Node Cells Is Caused by Apoptosis
Authors: Ura Hironobu , Yamada Nobuo , Torii Hideshi , Imakado Sumihisa , Iozumi Ken , Shimada Shinji 
Published: April 2015

AbstractWe report a case of histiocytic necrotizing lymphadenitis in a 28‐year‐old woman. The biopsy specimen of the enlarged lymph node showed lymphocytes, histiocytes, and a large amount of nuclear debris as well as marked eosinophilic deposits. We found DNA fragments by means of the modified TUNEL method, especially in the transitional area between intact cells and the foci of eosinophilic deposits and the cells positive for anti‐Fas antibody in the biopsied lymph node. Therefore, the necrotic appearance of the lymph node was thought to be caused by apoptosis induced by the Fas‐Fas ligand system. We hypothesize that the apoptosis was strongly related to the pathogenesis of this disease.
Eruptive Vellus Hair Cyst in a Patient with Pachyonychia Congenita
Authors: Lee g‐Tak , Chang Seung‐Ho , Yoon Tae‐Young 
Published: April 2015

AbstractPachyonychia congenita is characterized by symmetrical nail dystrophy, palmoplantar keratoderma, oral leukokeratosis, and follicular hyperkeratosis. In addition to these features, multiple cutaneous cysts of various kinds have been described.We report a case of pachyonychia congenita associated with eruptive vellus hair cyst.
Clinical and Immunological Characterization of Patients with Systemic Sclerosis Overlapping Primary Biliary Cirrhosis: A Comparison with Patients with Systemic Sclerosis Alone
Authors: Akimoto Sachiko , Ishikawa Osamu , Muro Yoshinao , Takagi Hitoshi , Tamura Taeko , Miyachi Yoshiki 
Published: April 2015

AbstractLimited cutaneous systemic sclerosis (ISSc) or CREST syndrome is sometimes complicated by primary biliary cirrhosis (PBC). To characterize the clinical and immunological features of patients with SSc overlapping PBC (SSc‐PBC), the clinical and laboratory data of 11 SSc‐PBC were studied. Since all of the SSc‐PBC were ISSc, the features of SScP‐BC were compared with those of 266 patients with ISSc alone. The sera from SSc‐PBC showed a significantly higher positivity for anti‐centromere antibody (ACA) (p<0.0005) and higher reactivity to centromere protein‐C. Although SSc‐PBC more frequently exhibited calcinosis and telangiectasia (p<0.05), there was no statistical difference in other features of CREST syndrome. There was no statistical difference in other scleroderma‐related features either. SSc‐PBC were more frequently complicated with Sjögren syndrome (p<0.05). The most prominent feature of SSc‐PBC was a higher incidence of ACA than in ISSc alone.
A Japanese Case of Dengue Fever with Lymphocytic Vasculitis: Diagnosis by Polymerase Chain Reaction
Authors: Ishikawa Hiroshi , Okada Shigeru , Katayama Ichiro , Mazaki Hironori , Nagatake Takeshi , Hasebe Futoshi , Igarashi Akira 
Published: April 2015

AbstractA 37‐year‐old Japanese male was admitted to Nagasaki University Hospital with abrupt onset of biphasic fever, general malaise and myalgia 9 days after coming back to Japan from Manila. He developed a rubella like erythematous rash 3 days after admission and purpuric eruption one week after admission. A biopsied specimen from the purpura revealed lymphocytic vasculitis with T cell dominance and without immunoglobulin or complement deposition around the blood vessels. RT‐PCR analysis on peripheral blood mononuclear cells using dengue virus specific primers confirmed the diagnosis of type 3 dengue fever.PCR analysis using virus specific primers is a rapid and valuable method for making a correct diagnosis of dengue fever.
A Case of Hypohidrotic Ectodermal Dysplasia
Authors: Park Jin Woo , Hwang Jae Young , Lee Sung Yul , Lee Jong Suk , Go Myoung Kwon , Whang Kyu Uang 
Published: April 2015

AbstractHypohidrotic ectodermal dysplasia (HED) is a rare, hereditary, congenital disease that affects several ectodermal structures. It is characterised by the following: anhidrosis or hypohidrosis, dental abnormalities, hypotrichosis, and a characteristic facies. The face shows prominent frontal bosses, supraorbital ridges and depressed bridges.We experienced a case of hypohidrotic ectodermal dysplasia in a 43‐year‐old male who had four characteristic features. A skin biopsy from the palm showed a total absence of the eccrine glands. The diagnosis was made on the basis of clinical features and skin biopsy findings.
Hydroxyurea‐Related Leg Ulcers in a Patient with Chronic Myelogenous Leukemia: A Case Report and Review of the Literature
Authors: Kato Naoko , Kimura Kumiko , Yasukawa Kana , Yoshida Kouki 
Published: April 2015

AbstractThe unusual appearance of extensive skin ulcerations has been reported in patients with chronic myelogenous leukemia (CML) undergoing continuous chemotherapy with hydroxyurea. It is thought that hydroxyurea, an antineoplastic agent with selective cytotoxicity for cells that divide most actively (such as those of the skin), causes these ulcerations through impairment of normal wound healing in areas of common trauma. The most common site of ulcers is the leg, where the ulcers are often extremely painful, with violaceous macules surrounding them, and are associated with extensive edema. On biopsy, histological vascular changes include leukocytoclastic vasculitis, perivascular lymphocytic infiltration, formation of thrombus, swelling of the endothelial cells, and thickening of the vascular walls. We report successful split‐thickness skin grafting on hydroxyurea‐related leg ulcers after preoperative discontinuation of hydroxyurea treatment in a patient with CML. The possible pathogenesis of hydroxyurea‐related leg ulcers is discussed.
The Potential Role of Skin Protein Kinase C Isoforms Alpha and Delta in Mouse Hair Growth Induced by Diphencyprone‐Allergic Contact Dermatitis
Authors: Li Lin‐feng , Fiedler Virginia C. , Kumar Raj 
Published: April 2015

AbstractThe levels of protein kinase C (PKC) isoforms α and δ in mouse hair growth induced by diphencyprone (DPCP)‐allergic contact dermatitis (ACD) were studied. BALB/c mice were sensitized by 2% DPCP in acetone on one side of their shaved backs and rechal‐lenged with 0.1% DPCP on the same side weekly for 2 weeks. The opposite side treated with acetone served as a control. Before each elicitation, mice were shaved again in order to observe the hair growth that followed. Enhancement of hair growth on DPCP treated skin was observed in 94% of mice after first elicitation and significant hair growth was shown in all mice after second elicitation. No remarkable hair growth was seen on the control side. Western immunoblot analysis revealed that the level of skin PKC α on the DPCP treated side was decreased at 2 and 4 days after sensitization and returned to the control level after first elicitation. At 5 days after the second elicitation, a higher level of PKC α was detected. The level of PKC δ remained at the control level and increased at 5 days after second elicitation. These results suggest that: 1) In the first week after sensitization, PKC α was down‐regulated. This down‐regulation may play a role in DPCP‐ACD induced hair growth; 2) after the elicitation, PKC α was over‐expressed and this over‐expression was roughly correlated with the enhancement of mouse hair growth, suggesting that over‐expression of PKC δ may also play a part in the proliferation of hair follicle cells; and 3) over‐expression of PKC δ after second elicitation may have an inhibitory effect on hair growth that keeps hair growth in balance.
Treatment of Reticular Erythematous Mucinosis with a Large Dose of Ultraviolet B Radiation and Steroid Impregnated Tape
Authors: Yamazaki Sayuri , Katayama Ichiro , Kurumaji Yuko , Yokozeki Hiroo , Nishioka Kiyoshi 
Published: April 2015

AbstractTo date, there are no successful treatments for reticular erythematous mucinosis (REM) other than antimalarial drugs such as chloroquine; these have many adverse side effects and are prohibited for use in Japan. We report a case of REM improved by a large dose of ultraviolet B (UVB) radiation and a steroid impregnated tape. The large dose of UVB radiation improved the erythema after 5 weeks. Application of steroid impregnated tape to a lesion where a large dose of UVB had been given produced an additive clinical effect. UVB radiation and steroid impregnated tape are considered to be effective treatments for REM.
A Case of Actinic Prurigo in Thailand
Authors: Akaraphanth Rutasanee , Gritiyarangsan Pimonpum 
Published: April 2015

AbstractActinic prurigo is a separate entity from the polymorphous light eruption that affects American Indians. It has been reported mainly from North and South America, with only few reported cases from Britain or Asia. We report a case of actinic prurigo in a Thai girl who showed cheilitis and pruritic papules on exposed areas for three years. We were able to induce populovesicular lesions by three consecutive irradiations with 100 J/cm2 UVA and 2 minimal erythematous dose of UVB. However, three weeks after irradiation, a prurigo papule developed at the UVB irradiated site.
Subcutaneous Cysticercosis Involving the Eyelid: Sonographic Diagnosis
Authors: Gupta Somesh , Jain Vijay Kumar , Sen Jyotsna , Gupta Sanjeev , Arora Brij 
Published: April 2015

AbstractA 25‐year‐old man and a 14‐year‐old boy presented with neurocutaneous cysticercosis involving the eyelid. Both patients had hundreds of scattered subcutaneous cysticerci. They were arranged in clusters over the sternocleidomastoid muscle in the neck. Such clustering of cysticerci is highly suggestive of central nervous system (CNS) involvement, as both the sternocleidomastoid muscle and the CNS are supplied by the carotid artery and cysticerci travel via the hematogenous route. We used ultrasonography to diagnose subcutaneous cysticercosis, which showed characteristic low reflective cysts and high reflective scolices inside. Although subcutaneous cysticerci are inconsequential, their verification is important in the diagnosis of more severe CNS involvement. They may be confused with other painless swellings such as lymphadenopathies, neurofibromas, and epidermoid cysts.