bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associations between digital health literacy and health system navigating abilities among Norwegian adolescents: validating the HLS19-DIGI scale using Rasch modeling
Authors: Le Christopher , Guttersrud Øystein , Levin-Zamir Diane , Griebler Robert , Finbråten Hanne Søberg 
Published: July 2024

Abstract
Background
Despite increasing global attention to health literacy and adolescents’ digital health information seeking, no unidimensional instruments measuring digital health literacy (DHL) in adolescents have reportedly been validated using Rasch modeling. Moreover, the evidence of adolescents’ abilities to navigate the health system (NAV-HL) in light of their DHL proficiency is still scarce. Therefore, our study aims to evaluate the psychometric properties of a DHL instrument (HLS19-DIGI scale) in order to investigate DHL in adolescents and young adults aged 16–25 and associations with abilities to navigate the health system.

Methods
A population-based cross-sectional survey among 890 Norwegian adolescents was conducted during April–October 2020 using computer-assisted telephone interviewing. Rasch modeling, independent samples t-test, chi-square test, and binary regression models were used to analyze the data.

Results
The HLS19-DIGI scale was sufficiently unidimensional, whereas no differential item functioning or disordered response categories were observed. However, relatively poor targeting was revealed indicating too many easy items for the target population. Yet, a high proportion (54%) of low DHL proficiency in adolescents was observed, as well as DHL was positively associated with the abilities to navigate the health system.

Conclusions
The HLS19-DIGI scale is considered a sufficiently unidimensional and valid instrument for measuring DHL in adolescents, which may be a useful tool for health authorities, public health workers, and health service providers. While DHL affects adolescents’ abilities to navigate the health system, future research should measure and examine their ability to utilize digital health services, separately.
Association of sleep and generalized anxiety disorder in Korean adolescents
Authors: Ko Ah Jung , Kim Jinhyun , Park Eun-Cheol 
Published: July 2024

Abstract
Background
Generalized anxiety disorder (GAD) is a common anxiety disorder among adolescents, significantly impacting their concentration and learning capabilities. The connection between emotional well-being and sleep is well-established, and Korean adolescents are particularly prone to inadequate sleep. This study aimed to determine the association between sleep duration and GAD in Korean adolescents.

Methods
This study was conducted using data from 106,513 adolescents aged 12–18 years. Data from the 2020–2022 Korea Youth Risk Behavior Survey were used. Sleep duration was classified into five groups, based on an average sleep duration of 7–7.9 h in adolescents. Social jet lag was defined as a misalignment between an individual's biological and social clocks. Differences in sleep duration between weekdays and weekends, social jet lag, and bedtime were each classified into three categories. Multiple logistic regression analysis was performed to evaluate the association between sleep duration and GAD.

Results
Comparing the five groups classified based on sleep duration, adolescents in the groups that slept less experienced a significant increase in the odds of developing GAD (adjusted odds ratio [aOR]: boys: 1.10 in the 6.0–6.9-h group, 1.14 in the 5.0–5.9-h group, and 1.23 in the ≤ 4.9-h group; girls: 1.05 in the 6.0–6.9-h group, 1.19 in the 5.0–5.9-h group, 1.22 in the ≤ 4.9-h group). Adolescents with poor sleep quality experienced more frequent instances of inadequate sleep (aOR: boys: 2.51; girls: 2.43).

Conclusions
GAD is strongly associated with insufficient sleep. Consequently, it is imperative to assess and address GAD in adolescents with irregular sleep patterns.
The association between vitamin E intake and hepatic steatosis in general and obese populations
Authors: Chen Bin , Han Li , Chen Xingxing 
Published: July 2024

Abstract
Purpose
Using data from the National Health and Nutrition Examination Survey (NHANES) and employing Controlled Attenuation Parameter (CAP) measures, this study explores the correlation between vitamin E (VE) intake and hepatic steatosis and its impact on different subsets.

Materials and methods
We selected 5757 participants with CAP data from the 2017–2020 NHANES dataset. Daily VE intake was assessed by a 24-hour dietary recall. Hepatic fat content was quantified using transient elastography to measure CAP. Stratified multivariable regression analysis investigated relationships in different subsets, and a generalized additive model identified nonlinear relationships and thresholds.

Results
After adjusting for confounders, higher VE intake correlated with lower CAP levels. Subgroup analyses and tests for interaction revealed a significantly stronger negative correlation between VE intake and CAP in obese individuals. Further analysis indicated a curvilinear relationship between VE intake and the severity of liver fat degeneration in both the general study population and the obese subgroup, demonstrating a threshold effect. In the general population, VE intake below the threshold (6.58 mg/day) is positively correlated with CAP levels, whereas intake above this threshold shows a negative correlation. For obese individuals, the threshold is set at 7.37 mg/day, above which the negative correlation with CAP is even more pronounced.

Conclusion
Our study revealed a negative correlation between VE intake and hepatic fat content, highlighting the potentially crucial role VE plays in obese fatty liver patients. Importantly, we identified threshold effects of VE intake in both general and obese populations. Our results support clinical nutritional interventions, personalized dietary guidance, and the development of drugs to combat fatty liver.
STAU1-mediated CNBP mRNA degradation by LINC00665 alters stem cell characteristics in ovarian cancer
Authors: Liu Xiaofang , Chen Yang , Li Ying , Bai Jinling , Zeng Zhi , Wang Min , Dong Yaodong , Zhou Yingying 
Published: July 2024

Abstract
Background
To investigate the role of lncRNA LINC00665 in modulating ovarian cancer stemness and its influence on treatment resistance and cancer development.

Methods
We isolated ovarian cancer stem cells (OCSCs) from the COC1 cell line using a combination of chemotherapeutic agents and growth factors, and verified their stemness through western blotting and immunofluorescence for stem cell markers. Employing bioinformatics, we identified lncRNAs associated with ovarian cancer, with a focus on LINC00665 and its interaction with the CNBP mRNA. In situ hybridization, immunohistochemistry, and qPCR were utilized to examine their expression and localization, alongside functional assays to determine the effects of LINC00665 on CNBP.

Results
LINC00665 employs its Alu elements to interact with the 3’-UTR of CNBP mRNA, targeting it for degradation. This molecular crosstalk enhances stemness by promoting the STAU1-mediated decay of CNBP mRNA, thereby modulating the Wnt and Notch signaling cascades that are pivotal for maintaining CSC characteristics and driving tumor progression. These mechanistic insights were corroborated by a series of in vitro assays and validated in vivo using tumor xenograft models. Furthermore, we established a positive correlation between elevated CNBP levels and increased disease-free survival in patients with ovarian cancer, underscoring the prognostic value of CNBP in this context.

Conclusions
lncRNA LINC00665 enhances stemness in ovarian cancer by mediating the degradation of CNBP mRNA, thereby identifying LINC00665 as a potential therapeutic target to counteract drug resistance and tumor recurrence associated with CSCs.
A PERMA model approach to well-being: a psychometric properties study
Authors: Al-Hendawi Maha , Alodat Ali , Al-Zoubi Suhail , Bulut Sefa 
Published: July 2024

AbstractPsychological well-being influences all the facets of adolescent success. This study examined the psychometric properties of PERMA, a subjective well-being measure consisting of five domains: positive emotions, engagement, relationships, meaning, and accomplishment. The sample size consisted of 502 high school students from public schools in Qatar. Contrary to expectations, the five-factor structure for PERMA did not fit our data well; however, after refining the model by the errors of the covariances between items, the one-factor model was found to be applicable. Multivariate analysis revealed that socioeconomic status (SES) and level of academic performance were independently and positively associated with overall well-being scores, whereas internalizing and externalizing behaviors were negatively associated. Notably, no significant effects of gender or age on well-being were observed. These findings suggest that interventions specific to socioeconomic status, academic excellence, and internalizing and externalizing behaviors in the school setting can produce more effective outcomes concerning student well-being.
Penny Wise and Pound Foolish: Does Striving to Meet Earnings Expectations by Manipulating Real Activities Trigger Product Recalls?
Authors: Chen Yangyang , Ma Lijun , Pittman Jeffrey , Yang Xin 
Published: July 2024

We examine whether managers’ activities in striving to reach earnings targets through real earnings manipulation affect their firms’ product recalls. Our evidence implies that firms suspected of manipulating real activities in trying to meet earnings benchmarks exhibit a higher likelihood and frequency of product recalls. In cross-sectional results consistent with expectations, we find that the impact of exploiting real activities to attain earnings benchmarks on product recalls intensifies for firms whose managers have stronger incentives to manage earnings and subsides for firms subject to greater customer power and firms with more growth opportunities. Additional analysis shows that lowering product quality to meet or beat earnings expectations undermines firms’ future performance. This paper was accepted by Ranjani Krishnan, accounting. Funding: Y. Chen acknowledges the General Research Fund of the Research Grants Council of Hong Kong [Project 15504219] for financial support. L. Ma acknowledges financial support from the Ministry of Education Project of Humanities and Social Sciences [Project 22YJC630099] and the Young Scholars Grant Program of the University of International Business and Economics [Project 20YQ06]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.04035 .
Fair Shares: Feasibility, Domination, and Incentives
Authors: Babaioff Moshe , Feige Uriel 
Published: July 2024

We consider fair allocation of indivisible goods to n equally entitled agents. Every agent i has a valuation function vi from some given class of valuation functions. A share s is a function that maps [Formula: see text] to a nonnegative value. A share is feasible if for every allocation instance, there is an allocation that gives every agent i a bundle that is acceptable with respect to vi, one of value at least her share value [Formula: see text]. We introduce the following concepts. A share is self-maximizing if reporting the true valuation maximizes the minimum true value of a bundle that is acceptable with respect to the report. A share s ρ-dominates another share [Formula: see text] if [Formula: see text] for every valuation function. We initiate a systematic study of feasible and self-maximizing shares and a systematic study of ρ-domination relation between shares, presenting both positive and negative results. Funding: The research of M. Babaioff is supported in part by a Golda Meir Fellowship. The research of U. Feige is supported in part by the Israel Science Foundation [Grant 1122/22].
Evaluation of the hemoglobin cutoff point for anemia in adult women residents of different altitudinal levels in Peru
Authors: Vásquez-Velásquez Cinthya , Gonzales Gustavo F. 
Published: July 2024

Background
Anemia prevalence is high in countries where high proportion of the population lives at high altitude (HA) due perhaps to the unsuitability hemoglobin correction factor proposed by the WHO. The present study has been designed to evaluate a new approach to establish thresholds of hemoglobin (Hb) when defining anemia at HA.

Materials & methods
Cross-sectional study evaluating 217 women aged 18 to 75 years-old, residents of 2 cities at low altitude (LA) (130 and 150 meters) and 2 at HA (3800 and 4300 meters). Hb, pulse oxygen saturation (SpO2), arterial oxygen content (CaO2), and inflammatory markers were measured. Three definitions of anemia diagnoses were used: uncorrected Hb, WHO-corrected Hb, and Silubonde’s criteria based on ferritin as a gold standard. STATA v18.0 was use for data analysis, p<0.05 indicated significant difference.

Results
HA residents present higher Hb values than at LA. Likewise, the highest area under the curve (AUC) ROC (Receiver Operating Characteristic) was observed for uncorrected Hb (AUC = 0.8595; CI95% 0.858–0.86) for the diagnosis of anemia using serum ferritin as the gold standard. Anemia prevalence was higher when using WHO-corrected Hb, 27%, and Silubonde’s criteria, 41% (Hb cut-off of 11.10, 12.73, 15.80 and 16.60 g/dl for altitudes of 130, 150, 3800 and 4300 meters, respectively), than using uncorrected Hb to define anemia (7.7%). Serum Ferritin and CaO2 values are lower only in the group with anemia defined with uncorrected Hb than in the groups of anemia using the WHO-corrected Hb or the Silubonde´s criteria.

Conclusions
The correction factor of hemoglobin for altitude of residence overestimates the prevalence of anemia in adult women. Likewise, CaO2 could be a potential marker to determine the transport of oxygen in LA and HA populations. Further studies in adult men are required to confirm the present findings.
Elecciones, trayectorias y desigualdades en el acceso a la educación superior: Un análisis con base en el panel de jóvenes evaluados por PISA 2009 en Uruguay
Authors: Fernández Aguerre Tabaré , Cedréz Maximiliana 
Published: July 2024

La universidad uruguaya presenta una “paradoja de acceso”: Diseño institucional abierto y matriculación restringida. Esto conforma un problema para la política educativa y el análisis sociológico relacionado con los perfiles de ingresantes y los procesos de selección social subyacentes. Dos son las preguntas centrales: ¿Quiénes acceden a la Universidad de la República (UDELAR)?; y ¿Cuánto pesan las experiencias anteriores y los orígenes sociales? La novedad que proponemos aportar es mediante el análisis de datos excepcionales, combinando la Encuesta aplicada en el año 2014 a una muestra nacional representativa de los jóvenes evaluados por PISA en el año 2009, y de microdatos administrativos generados por la UDELAR. La ventana de observación es de 10 años, con información socioeconómica del hogar de origen, trayectoria en la Educación Media, eventos laborales, eventos familiares, ingreso y elección de una o más de una carrera al ingreso. Esto nos permite ordenar el papel lógico, estableciendo la precedencia temporal y robusteciendo la base empírica permitiendo formular inferencias causales. En particular, nuestro objetivo principal será poner a prueba tres hipótesis que permiten articular el papel de “condensación de desigualdades” que el tipo de transición a la adultez tendría sobre el acceso a la ES.
Turkish textile and clothing SMEs: Importance of organizational learning, digitalization, and internationalization
Authors: Divrik Bahar , Baykal Elif 
Published: July 2024

Abstract
The Turkish textile and clothing (TTC) industries, which are mainly made of small and medium enterprises (SMEs), are the main source of export for the Turkish economy since the end of 1980s. The introduction of digital technologies has changed the competition for the TTC industries and this change has been accelerated after the covid-19 pandemic. Digitalization of SMEs is accepted as a social and technical process in which organizational learning is the main actor and therefore, the aim of this research is to explore the relation between organizational learning, digitalization, and internationalization for TTC industries. A parallel-results convergent mixed method approach in which qualitative and quantitave analysis are performed seperately and integrated later is applied in this research. The data of the research were collected by semi-structured interviews and survey questionnaires, which are analyzed in MAXQDA and analysis of moment structures.
Atypical presentation of γ/δ mycosis fungoides with an unusual phenotype and SOCS1 mutation
Authors: Nielsen Pia Rude , Schejbel Lone , Josefsson Pär Lars , Skov Lone , Nielsen Signe Ledou 
Published: July 2024

Abstract
Mycosis fungoides is the most frequent subtype of primary cutaneous T-cell lymphomas. The diagnosis is based on a thorough clinic-pathologic correlation, which can, especially in early-stage disease, be challenging due to similarities with several benign skin disorders such as psoriasis and atopic dermatitis. Here, we present a case of an 81-year-old man with a 20-year-long medical history of skin problems treated as psoriasis with limited effect. Since December 2021, the patient experienced worsening of his skin symptoms with rapidly growing tumors and widespread patches and plaques. Positron emission tomography/computed tomography evaluation revealed markedly metabolic activity related to the skin tumors and increased FDG uptake in several retroperitoneal lymph nodes. Histological assessment of skin biopsies demonstrated a highly proliferative T-cell lymphoma with a γ/δ+ and CD8+ cytotoxic phenotype. The morphology of the tumor cells appeared blastic with an abnormal immunephenotype CD3+, CD2−, CD5dim, CD4−, CD8+, CD56−, and CD30−. Next-generation sequencing detected a likely pathogenic SOCS1 mutation with an allele frequency of 72% as well as a STAT3 variant of unknown significance. This case highlights the diagnostic complexity of an indolent skin lymphoma evolving into an aggressive cytotoxic lymphoma.
The Post-Brown Era in Judicial Policymaking
Authors: Burke Thomas F. , Barnes Jeb 
Published: July 2024

Abstract

Brown v. Board of Education marked the beginning of a long era in American politics in which courts, litigation and legal rights were associated with progressive causes. That association, however, is now eroding. The left’s discontent with the Supreme Court is well known, but less attention has been paid to liberal concerns about judicial policymaking – including some of the very mechanisms honed by liberals in the Brown era – that go well beyond the Court. The Brown era obscured a simple truth about lawsuits that the next few years are likely to clarify: They are much better at gumming things up than they are at making things work. Policymaking through litigation, though associated with liberals in the Brown era, in fact reflects a deep distrust of centralized governance. Given that it is conservatives, not liberals, who are more often interested in constraining government, this makes lawsuits ordinarily a more congenial policy tool for Republicans than Democrats. For many elements of the Democratic agenda of the next few years, litigation is likely to prove a clumsy tool, more effective in the hands of opponents than proponents.
Experimental study on selected properties and microstructure of pine-based wood ceramics
Authors: Du Danfeng , Qiao Lulu , Guo Xiurong , Sun Chaowei , Liu Zexin , Gao Qi , Yang Shaochi , Zhang Yanlin 
Published: July 2024

Abstract
Wood ceramics using biomass materials as templates possess the benefits of facile fabrication and versatile applicability. To investigate the physical properties, chemical properties and microstructure of wood ceramics prepared from biomass materials, the basic properties and potential applications of wood ceramics were expounded. In this paper, wood powder wood ceramics (WPWC) and wood fiber wood ceramics (WFWC) were prepared through the vacuum carbonization method, utilizing pine powder and pine fiber as raw materials. The impact of phenolic resin concentration and mixture filling mass on various properties of wood ceramics, including mass loss rate (MLR), volume shrinkage rate (VSR), apparent porosity (AP), and bending strength (BS) were investigated on this basis. The microtopography and pore structure of wood ceramics were also analyzed. The test results show that an increase in the concentration of phenolic resin led to a decrease in the MLR, VSR, and AP of WPWC and WFWC, while their BS exhibited an increase. When the concentration of phenolic resin was 60 %, the phenolic resin yielded a BS of 8.70 MPa and 9.20 MPa for WPWC and WFWC, respectively. Furthermore, the microstructures of both WPFC and WFWC reveal hierarchical porous structures. The difference is that WPFC has a dispersed three-dimensional network topology in its overall morphology, which is mainly formed by filamentous or long linear glass carbon in wood ceramics dominated by carbon. The natural and consistent pore structure of WFWC is comparable to a three-dimensional honeycomb structure, the primary mesoporous size was around 40.28 nm and the main macropore size was more than 10,000 nm. It elucidates the pore structure of WPWC and WFWC, characterized by “hierarchical porosity”, the differences and relationships between porous wood ceramics derived from powdery and fibrous biomass as raw materials were analyzed, which contributes to the advancement of the fundamental principles of wood ceramics and establishes a theoretical basis for the practical exploration and development of biomass materials.
Immune landscape of hepatocellular carcinoma: The central role of TP53-inducible glycolysis and apoptosis regulator
Authors: Qiu Lingbing , Ma Tianyi , Guo Yunmiao , Chen Jugao 
Published: July 2024

Abstract

Objective
This study aims to address the substantive issue of lacking reliable prognostic biomarkers in hepatocellular carcinoma (HCC) by investigating the relationship between TP53-inducible glycolysis and apoptosis regulator (TIGAR) and HCC prognosis using The Cancer Genome Atlas database.

Methods
(1) Integrated statistical analyses, including logistic regression, Wilcoxon signed-rank test, and Kruskal–Wallis test, were conducted to explore the association between TIGAR expression and clinical–pathological features of HCC. (2) The Kaplan–Meier method combined with univariate and multivariate Cox regression models underscored TIGAR as a prognostic factor in HCC. (3) Gene set enrichment analysis (GSEA) revealed key pathways associated with TIGAR, while single-sample gene set enrichment analysis (ssGSEA) determined its relevance to cancer immune infiltration.

Results
(1) Elevated TIGAR expression was significantly correlated with decreased survival outcomes in HCC patients. (2) GSEA highlighted the significant link between TIGAR and humoral immunity. (3) ssGSEA revealed a positive correlation between TIGAR expression and infiltration of Th1 and Th2 cells and a negative correlation with Th17 cell infiltration.

Conclusion
TIGAR, as a potential prognostic biomarker for HCC, holds significant value in immune infiltration. Understanding the role of TIGAR could contribute to improved prognostic predictions and personalized treatment strategies for HCC patients.