bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of Migrastatin Analogues as Inhibitors of Tumour Cell Migration: Exploring Structural Change in and on the Macrocyclic Ring
Authors: Lo Re Daniele , Zhou Ying , Mucha Joanna , Jones Leigh F. , Leahy Lorraine , Santocanale Corrado , Krol Magdalena , Murphy Paul V. 
Published: November 2015

AbstractMigrastatin and isomigrastatin analogues have been synthesised in order to contribute to structure–activity studies on tumour cell migration inhibitors. These include macrocycles varying in ring size, functionality and alkene stereochemistry, as well as glucuronides. The synthesis work included application of the Saegusa–Ito reaction for regio‐ and stereoselective unsaturated macroketone formation, diastereoselective Brown allylation to generate 9‐methylmigrastatin analogues and chelation‐induced anomerisation to vary glucuronide configuration. Compounds were tested in vitro against both breast and pancreatic cancer cell lines and inhibition of tumour cell migration was observed in both wound‐healing (scratch) and Boyden chamber assays. One unsaturated macroketone showed low affinity for a range of secondary drug targets, indicating it is at low risk of displaying adverse side effects.
Resistive Switching Nanodevices Based on Metal–Organic Frameworks
Authors: Wang Zhengbang , Nminibapiel David , Shrestha Pragya , Liu Jianxi , Guo Wei , Weidler Peter G. , Baumgart Helmut , Wöll Christof , Redel Engelbert 
Published: November 2015

AbstractSURMOF (surface‐anchored metal–organic frameworks) thin films exhibit exciting chemical and physical properties, which can be modulated in a straightforward fashion to achieve specific benefits for numerous applications in future technologies. Here, we report a detailed characterization of resistive switching in crystalline SURMOF films of around ≈10, ≈20 and ≈50 nm thicknesses. These demonstrated switching characteristics combined with the ability to deposit monolithically oriented crystalline HKUST‐1 films with well‐defined thicknesses in the nm‐range on conductive substrates serving as bottom electrodes and to lithographically fabricate top‐electrodes opens up the possibility to employ these metal–organic hybrid materials as solid state devices for potential nonvolatile resistive random access memory (RRAM) memory applications. MOF bipolar switching RRAM devices based on SURMOFs with thicknesses of 10±5 nm, 20±5 nm and 50±5 nm show exceptionally promising performance. The huge flexibility of MOF materials with regards to device applications is demonstrated by loading guest molecules into the pores of these framework materials. In the case of ferrocene infiltration, we show that the already impressive performance of the SURMOF‐RRAM devices can be further improved. The results demonstrate the great potential of SURMOF thin films for the implementation of novel and scalable active materials for the next generation of digital processing and organic‐based microelectronic devices.
First Occurrence of Tetrazines in Aqueous Solution: Electrochemistry and Fluorescence
Authors: Fritea Luminiţa , Audebert Pierre , Galmiche Laurent , Gorgy Karine , Le Goff Alan , Villalonga Reynaldo , Săndulescu Robert , Cosnier Serge 
Published: November 2015

AbstractThe photophysical and electrochemical properties of tetrazines substituted by linear 2,3‐naphtalimide antennas and/or adamantane groups specifically dedicated to host–guest interactions with cyclodextrins are studied both in organic and aqueous media. In acetonitrile solvent, the reduction potential of tetrazine leading to the anion radical is shifted, depending on the electron‐withdrawing power of the substituent of the tetrazines. Due to the hydrophobic character of these compounds, their solubilization in aqueous solution is achieved successively in presence of either β‐cyclodextrins or gold nanoparticules modified by β‐cyclodextrins. We demonstrate that the formation of the inclusion compound tetrazine–cyclodextrin allows the solubilization of the tetrazines in aqueous solution. The supramolecular assemblies obtained in water retain tetrazine's emission properties, yielding a yellow fluorescence.
A Rational Synthetic Approach to 2,5‐Diphenyl‐β‐silyl Phospholes
Authors: Klintuch Dieter , Krekić Kristijan , Bruhn Clemens , Benkő Zoltán , Pietschnig Rudolf 
Published: November 2015

AbstractSystematic access to β‐silyl‐substituted phospholes is reported. The synthesis proceeds through the addition of lithium phosphanide to a diyne and silylation of the intermediate β‐lithio phosphole. By following this approach, mono and disilylation has been accomplished and the reactivity of the β‐silyl phospholes towards oxidation with chalcogens and conversion into phospholides has been explored. The silyl units have a significant impact on the fluorescence properties of the phosphole system, leading to increased Stokes shifts and blueshifted absorption with redshifted emission. The key compounds have been characterized by multinuclear NMR spectroscopy, mass spectrometry, and, in part, by single‐crystal X‐ray diffraction analysis.
Substituent Effects on Physical Properties and Catalytic Activities toward Water Oxidation in Mononuclear Ruthenium Complexes
Authors: Sato Yoichi , Takizawa Shin‐ya , Murata Shigeru 
Published: November 2015

AbstractA series of monomeric RuII complexes [Ru(bda)(pyR)2] (H2bda = 2,2′‐bipyridine‐6,6′‐dicarboxylic acid, pyR = pyridine with a substituent R at the 4‐position) were prepared, and the effects of substituent groups on the pyridine ligands of the complexes on catalytic activities toward water oxidation, as well as on photophysical and electrochemical properties, were examined. An increase in the electron‐withdrawing ability of the substituent results in a redshift of the absorption maximum assigned to the transition from the d orbital of Ru to the π* orbitals of the pyridine ligands, and an increase in the oxidation potential of the complex. These results are reasonably explained in terms of the variation of the energy level of molecular orbitals induced by the substituent group, which is supported by density functional theory calculations. The substituent effect on catalytic activity toward photochemical water oxidation using [Ru(bpy)3]2+ (bpy = 2,2′‐bipyridine) and S2O82– as a sensitizer and a sacrificial electron acceptor, respectively, is essentially analogous to that toward chemical water oxidation using CeIV as an oxidant in which the complexes with electron‐withdrawing groups exhibit better performance than those with electron‐donating groups. However, the Hammett analysis demonstrates that the catalytic activities of the complexes toward chemical and photochemical water oxidation show no straightforward dependence on the electronic nature of the substituent group, which suggests that a step accelerated by electron‐donating groups also contributes to the overall rate of water oxidation.
A first approach towards the development of geographical origin tracing models for North Moroccan olive oils based on triacylglycerols profiles
Authors: Bajoub Aadil , Medina‐Rodríguez Santiago , Hurtado‐Fernández Elena , Ajal El Amine , Ouazzani Noureddine , Fernández‐Gutiérrez Alberto , Carrasco‐Pancorbo Alegría 
Published: November 2015

The triacylglycerols composition of monovarietal Picholine Marocaine olive oils, produced in seven of the most productive areas in northern Morocco, has been established for the first time, starting a register of typicality and geographical identity of Moroccan olive oils. Two hundred seventy‐nine olive samples were collected over two consecutive crop seasons (2011/2012 (n = 140) and 2012/2013 (n = 139)), the analysis of the triacylglycerol profiles of the obtained oils was performed using high performance liquid chromatography, the influence of the region of provenance was investigated, and chemometric data analysis (including principal components analysis, linear discriminant analysis, partial least squares–discriminant analysis, and soft independent modeling of class analogies) was used to differentiate the studied samples according to their geographical origin. Twenty‐one triacylglycerols were characterized and the variability observed among the studied samples could be related to the production area. The combination of triacylglycerols composition with chemometrics provided a powerful tool to verify the geographical origin of north Moroccan olive oils.Practical applications: Moroccan legislations established Geographic Indication labels for adding value to typical products. However, the general procedure to control the geographical authenticity of these protected products remains based on the traceability of their production and there is a lack of appropriate and reliable tools for their geographical unambiguous authentication and control. In this work, geographical authentication models for classifying olive oil samples (based on triacylglycerols composition) have been developed and evaluated, achieving adequate classification and prediction rates for oils coming from the main north Moroccan olive growing areas. The results obtained herein, could represent a significant contribution to the control of the geographical authenticity of Moroccan olive oils.The triacylglycerols composition of monovarietal Picholine Marocaine olive oils, from seven of the most productive areas in northern Morocco, is established in this study, analyzing 279 olive samples (over two consecutive crop seasons) by high performance liquid chromatography and Chemometrics.
Phytosterol oxidation products (POP) in foods with added phytosterols and estimation of their daily intake: A literature review
Authors: Lin Yuguang , Knol Diny , Trautwein Elke A. 
Published: November 2015

To evaluate the content of phytosterol oxidation products (POP) of foods with added phytosterols, in total 14 studies measuring POP contents of foods with added phytosterols were systematically reviewed. In non‐heated or stored foods, POP contents were low, ranging from (medians) 0.03–3.6 mg/100 g with corresponding oxidation rates of phytosterols (ORP) of 0.03–0.06%. In fat‐based foods with 8% of added free plant sterols (FPS), plant sterol esters (PSE) or plant stanol esters (PAE) pan‐fried at 160–200°C for 5–10 min, median POP contents were 72.0, 38.1, and 4.9 mg/100 g, respectively, with a median ORP of 0.90, 0.48, and 0.06%. Hence resistance to thermal oxidation was in the order of PAE > PSE > FPS. POP formation was highest in enriched butter followed by margarine and rapeseed oil. In margarines with 7.5–10.5% added PSE oven‐heated at 140–200°C for 5–30 min, median POP content was 0.3 mg/100 g. Further heating under same temperature conditions but for 60–120 min markedly increased POP formation to 384.3 mg/100 g. Estimated daily upper POP intake was 47.7 mg/d (equivalent to 0.69 mg/kg BW/d) for foods with added PSE and 78.3 mg/d (equivalent to 1.12 mg/kg BW/d) for foods with added FPS as calculated by multiplying the advised upper daily phytosterol intake of 3 g/d with the 90% quantile values of ORP. In conclusion, heating temperature and time, chemical form of phytosterols added and the food matrix are determinants of POP formation in foods with added phytosterols, leading to an increase in POP contents.Practical applications: Phytosterol oxidation products (POP) are formed in foods containing phytosterols especially when exposed to heat treatment. This review summarising POP contents in foods with added phytosterols in their free and esterified forms reveals that heating temperature and time, the chemical form of phytosterols added and the food matrix itself are determinants of POP formation with heating temperature and time having the biggest impact. The estimated upper daily intakes of POP is 78.3 mg/d for fat‐based products with added free plant sterols and 47.7 mg/d for fat‐based products with added plant sterol esters.Phytosterols in foods are susceptible to oxidation to form phytosterol oxidation products (POP). This review summarizes literature data regarding POP contents of foods with added phytosterols that were exposed to storage and heat treatments.
Ion‐selective Electrodes with 3D Nanostructured Conducting Polymer Solid Contact
Authors: Szűcs Júlia , Lindfors Tom , Bobacka Johan , Gyurcsányi Róbert E. 
Published: November 2015

AbstractUntil now both ion‐to‐electron transducers as well as large surface area nanostructured conducting materials were successfully used as solid contacts for polymer‐based ion‐selective electrodes. We were interested to explore the combination of these two approaches by fabricating ordered electrically conducting polymer (ECP) nanostructures using 3D nanosphere lithography and electrosynthesis to provide a high surface area and capacitive interface for solid contact ion‐selective electrodes (SC‐ISEs). For these studies we used poly(3,4‐ethylenedioxythiophene)/poly(styrenesulfonate) (PEDOT(PSS)) films with 750 nm diameter interconnected pores as the intermediate layer between a glassy carbon electrode and a Ag+ ‐selective polymeric membrane. We also investigated the feasibility of loading the voids created in the polymer film with a lipophilic redox mediator (1,1’‐dimethylferrocene) to provide the respective ISEs with well‐defined/controllable E0 values. These expectations were fulfilled as the standard deviation of E0 values were reduced with almost an order of magnitude for 3D nanostructured SC‐ISEs filled with the redox mediator as compared to their redox mediator‐free analogs. The detrimental effect of the redox mediator extraction into the plasticized PVC‐based ion‐selective membrane (ISM) was efficiently suppressed by replacing the PVC‐based ISMs with a low diffusivity silicone rubber matrix.
Application of capacitively coupled contactless conductivity as an external detector for zone electrophoresis in poly(dimethylsiloxane) chips
Authors: Koczka Péter I. , Bodoki Ede , Gáspár Attila 
Published: November 2015

In this work, lab‐made PDMS microfluidic chips were matched to a capacitively coupled contactless conductivity detector (C4D) having external in‐plane electrodes (eDAQ, Australia). The advantages of this type of C4D are the choice to reversibly place or remove the microchip onto/from the detector and to freely variate the position of the detection (separation length) on the microchip. The thickness of the bottom layer of the PDMS chip was optimized to achieve sensitive detection during the electrophoretic separation. PDMS chips with 100 μm bottom layer used with the C4D platform were tested by CZE of a mixture of seven anions and different types of real samples. Using split‐flow pressure sample injection and effective length of 6.5 cm, the numbers of theoretical plates were in the range of 4000–6000 (63 000–93 000/m) and the LODs amounted to 3.66–14.7 μmol/L (0.13–2.26 μg/mL) for the studied anions.
Impact of the Solar Eclipse from 20th March 2015 on the German Electrical Supply—Simulation and Analysis
Authors: Killinger Sven , Kreifels Niklas , Burger Bruno , Müller Björn , Stiff George , Wittwer Christof 
Published: November 2015

AbstractThough solar eclipses are traditionally thought of as astronomic events with no real bearing on society, in fact they do manage to influence processes of practical importance by affecting the energy conversion of photovoltaic systems. The main goal of this study is to explore what could have happened to the German power supply and its reliability during the partial solar eclipse on the 20th March 2015. Comparing results of a simulation with an ex post analysis shows that: 1.) the possible effects could be predicted very accurately, 2.) the electrical supply was not threatened during the solar eclipse and would not have been subject to problems, even in a worst‐case scenario, 3.) the actual solar power gradients during the eclipse exceeded the maximum solar power gradients during normal operation observed in the past by at least a factor of two, and 4.) grid frequency analysis for the day of the solar eclipse shows that the maximum and minimum frequency values are well within manageable limits.
Reconstruction and homogenization of the longest instrumental precipitation series in the Iberian Peninsula (Barcelona, 1786–2014)
Authors: Prohom Marc , Barriendos Mariano , Sanchez‐Lorenzo Arturo 
Published: November 2015

ABSTRACTDetection and reconstruction of early instrumental series is an interdisciplinary activity that allows us to extend climate data records to periods prior to the mid‐19th century, extending the overlapping periods with climate proxies and characterizing extreme events. In this work, the collection of several data sources corresponding to different periods and locations, obtained with a wide range of methods and instruments by institutions or private observers, provides the following results: Barcelona has a continuous rainfall series with monthly resolution since 1786 and with daily resolution since 1850. It is worth mentioning that the records from Barcelona provide the longest continuous monthly series available on rainfall in the Iberian Peninsula. The monthly records have been homogenized by using a relative homogenization approach, HOMER. The results highlight the existence of five breaks, most of them due to relocations or instrumentation changes documented in the metadata, which have been adjusted to remove non‐climatic factors. The homogenized annual and winter precipitation series in Barcelona show a statistically significant increase from 1786 to 2014, although this increase is mainly due to the concentration of negative anomalies during the first half of the 19th century, which is also clearly visible in the seasonal series. Specifically, an extreme mega‐drought episode was observed from the 1810s to the 1830s, which is supported by different proxy data. For a better dissemination of the homogenized monthly series developed in this study, the data set is freely available to the research community.
Prescription Stimulants and PTSD Among U. S. Military Service Members
Authors: Crum‐Cianflone Nancy F. , Frasco Melissa A. , Armenta Richard F. , Phillips Christopher J. , Horton Jaime , Ryan Margaret A. K. , Russell Dale W. , LeardMann Cynthia 
Published: November 2015

AbstractPosttraumatic stress disorder (PTSD) is a prevalent condition among military service members and civilians who have experienced traumatic events. Stimulant use has been postulated to increase the risk of incident PTSD; however, research in this area is lacking. In this study, the association between receipt of prescription stimulants and PTSD was examined in a secondary analysis among active duty U.S. military members (n = 25,971), participating in the Millennium Cohort Study, who completed a baseline (2001–2003) and two follow‐up surveys (between 2004–2008). Prescription stimulant data were obtained from the military Pharmacy Data Transaction Service. PTSD was assessed using the PTSD Checklist–Civilian Version and incident PTSD was defined as meeting the criteria at follow‐up among those who did not have a history of PTSD at baseline. Overall, 1,215 (4.7%) persons developed new‐onset PTSD during follow‐up. Receipt of prescription stimulants were significantly associated with incident PTSD, hazard ratio = 5.09, 95% confidence interval [3.05, 8.50], after adjusting for sociodemographic factors, military characteristics, attention‐deficit/hyperactivity disorder, baseline mental and physical health status, deployment experiences, and physical/sexual trauma. Findings suggested that prescription stimulants are associated with incident PTSD among military personnel; these data may inform the underlying pathogenesis of and preventive strategies for PTSD.
Factors associated with older people's independent living from the viewpoint of health and functional capacity: a register‐based study
Authors: Ahlqvist Anette , Nyfors Hanna , Suhonen Riitta 
Published: November 2015

AbstractAimThe aim of this study was to identify factors associated with independent living of older people from the point of view of health and functional capacity.BackgroundLiving independently at home is major wish for older people but is depending on health and functional capacity among others. Objective and subjective assessments have been considered important in determining threats for independent living but both of these views have rarely included in the same study.DesignDescriptive, cross‐sectional register‐based study was conducted.MethodsData were collected using the Health and Functional Capacity survey by identifying the factors of health examinations of a cohort (N = 292) of 75‐year old's, born in 1936 (N = 388), in one Finnish medium‐sized municipality in 2011. This study is part of the Functional Ageing project Kaste 2013. The data were analysed statistically by using descriptive analysis, cross‐tabulation and logistic regression.ResultsPartly, different factors were associated with subjective and objective health and functional capacity showing wide range of individuality. Worsening subjective health was associated with worsened self‐assessment of life situation. Worsening subjective health threatens independent living. Factors statistically significantly associated with worsening subjective health were low physical activity, falls during the last 6 months, not managing heavy housework, being sometimes lonely or dejected, having diagnosed diseases or health problems and polypharmacy.
Maternal–fetal medicine specialists' experiences of conducting feticide as part of termination of pregnancy: a qualitative study
Authors: Fay Vanessa , Thomas Sophie , Slade Pauline 
Published: November 2015

AbstractObjectivesThis study aimed to explore maternal–fetal medicine specialists' experiences of conducting feticide in late termination of pregnancy.MethodsParticipants were recruited via email. Purposeful sampling resulted in ten maternal–fetal specialists. Semistructured interviews were used to examine their experiences of conducting feticide. Interviews occurred across four English National Health Service hospitals. Interpretative phenomenological analysis was used.ResultsAn ongoing doctor–patient relationship when conducting feticide facilitated participants' self‐image as clinicians rather than technicians. Coping involved rationalisation, with feticide viewed as ‘part of the job’. Supportive team relationships helped keep emotional expression within control. Participants were not distressed if they felt, through relationship‐based decision‐making, that the feticide aligned with their values and legal interpretation. To avoid negative judgements, they disclosed selectively, only telling trusted individuals that they conducted feticides.ConclusionsParticipants experienced conducting feticides as difficult but necessary, eliciting pride from the skills involved. Some noted management of personal distress. Optimal conditions were involvement in the process from the initial decision‐making and team support. Providing feticides was deemed as potentially stigmatising, with selective disclosure employed. Training in managing feticides and guidance on providing optimal service conditions may decrease selectivity of disclosures and enhance staff well‐being and the quality of feticide provisions. © 2015 John Wiley & Sons, Ltd.