bluuebunny/crossref_metadata_2025_split huggingface dataset:
Participant‐Centered Engagement for Sustained Adherence to Smartwatches: A 12‐Month Prospective Decentralized Digital Health Study
Authors: Wilton Angelina R. , Saliba Christina T. , Marrero‐Polanco Jean , Sheffield Katharine , Wilkes Quantia , Anacker Miriam , Croarkin Paul E. , Chauhan Mohit , Dyrbye Liselotte N. , Chesak Sherry , Bobo William V. , Athreya Arjun P. 
Published: February 2025

ABSTRACTAdherence in digital health studies with extended observation periods (≥ 12 months) is limited, and participant retention considerably reduces with time. The US Food and Drug Administration has issued guidelines for improving participant engagement, adherence, and diversity in digital health studies combined with decentralized procedures. A decentralized digital health study on well‐being was designed with protocolized procedures to study the feasibility of participant engagement and technology support to facilitate adherence (wearing the smartwatch ≥ 70% of time) sustained over a 12‐month period. At the end of the study, participants were asked about their ease of participation and free‐response questions about how wearing the smartwatches impacted their physical wellness. An inductive thematic analysis (ITA) was performed to assess themes of those responses and association with adherence. A total of 298 participants were recruited between 2022 and 2023 (n = 129 in Cohort A in October 22, n = 169 in Cohort B in April 23), with 23% non‐white participants accrued. Among the 298 participants accrued, 273 (92% of accrued participants) completed the 12‐month study with an average overall adherence of 77.4% (SD = 32.64) wear‐time across 12 months. Median adherence of participants whose responses exemplified an ITA theme encompassing perceived behavior changes in sleep and physical activity was higher than those who did not have a response exemplifying that theme. Conversely, those expressing perceived discomfort or intrusiveness of the smartwatch had a statistically lower adherence. These results highlight the crucial roles of technology support and robust engagement efforts to enable sustained adherence over extended follow‐up periods in decentralized digital health studies.
Underpowered studies and exaggerated effects: A replication and re‐evaluation of the magnitude of anchoring effects
Authors: Li Tongzhe , Weigel Collin , Ferraro Paul , Messer Kent D. 
Published: February 2025

AbstractWe reconsider one of the most widely studied behavioral biases: anchoring effects. We estimate that study designs in this literature, including replication studies, routinely fail to achieve statistical power of more than 30%. This study replicates an anchoring study that reported an effect size of a 31% increase in participants' bids. In the replication, we increased the design's statistical power from 46% to 96%, reducing the average exaggeration of a statistically significant result by a factor of seven. Our replication results reject the size of the original estimated effects. We find an estimated effect of 3.4% (95% CI [−3.4%, 10%]).
Sustained Improvement in Health‐Related Quality of Life in Transplant‐Ineligible Newly Diagnosed Multiple Myeloma Treated With Daratumumab, Lenalidomide, and Dexamethasone: MAIA Final Analysis of Patient‐Reported Outcomes
Authors: Perrot Aurore , Facon Thierry , Plesner Torben , Usmani Saad Z. , Kumar Shaji , Bahlis Nizar J. , Hulin Cyrille , Orlowski Robert Z. , Nahi Hareth , Mollee Peter , Ramasamy Karthik , Roussel Murielle , Jaccard Arnaud , Delforge Michel , Karlin Lionel , Arnulf Bertrand , Chari Ajai , Wang George , Gupta‐Werner Niodita , Kaila Shuchita , Pei Huiling , Matt Kathryn , Gries Katharine S. , Carson Robin , Borgsten Fredrik , Weisel Katja 
Published: February 2025

ABSTRACTObjectivesThis final post hoc analysis evaluated patient‐reported outcomes from the Phase 3 MAIA study of daratumumab, lenalidomide, and dexamethasone (D‐Rd) versus lenalidomide and dexamethasone (Rd) after median 64.5‐month follow‐up in transplant‐ineligible patients with newly diagnosed multiple myeloma (NDMM), including patient subgroups.MethodsKey scales from the EORTC QLQ‐C30 (global health status [GHS], physical functioning, pain, and fatigue) were assessed. Scores were evaluated every 3 months for 1 year, then every 6 months until disease progression.ResultsThe intent‐to‐treat population (n = 737) included 46.3% frail, 35.4% 70 to < 75 years old, and 43.6% ≥ 75 years old. D‐Rd‐treated patients showed improvements from baseline that were sustained over 5 years in the intent‐to‐treat population and across subgroups by age, frailty, and bone lesions. Greater proportions of patients treated with D‐Rd versus Rd achieved minimally important changes for improvement at cycle 36 (year ~3) in GHS (odds ratio, 1.84 [95% CI, 1.16–2.91]), physical functioning (1.93 [1.18–3.14]), pain (1.41 [0.90–2.22]), and fatigue (2.00 [1.24–3.23]). Greater proportions of patients with bone lesions improved with D‐Rd versus Rd on GHS and physical functioning.ConclusionsIn transplant‐ineligible patients with NDMM, D‐Rd improved health‐related quality of life over a 5‐year period versus Rd.Trial Registration: ClinicalTrials.gov: NCT02252172
RNA Sequencing Reveals the Long Non‐Coding RNA Signature in Psoriasis Keratinocytes and Identifies CYDAER as a Long Non‐Coding RNA Regulating Epidermal Differentiation
Authors: Freisenhausen Jan Cedric , Luo Longlong , Kelemen Evelyn , Elton Jonathan , Skoog Viktor , Pivarcsi Andor , Sonkoly Enikö 
Published: February 2025

ABSTRACTPsoriasis is a common chronic inflammatory skin disease determined by genetic and environmental factors, resulting in the activation of IL‐23/IL‐17‐mediated immune response, epidermal hyperproliferation, and keratinocyte activation. Long non‐coding RNAs (lncRNAs) are non‐protein‐coding transcripts > 500 nucleotides with diverse regulatory functions; their role in epidermal dysfunction in psoriasis is poorly understood. To identify epidermal transcripts with potential roles in psoriasis, including lncRNAs, we performed RNA sequencing on keratinocytes from psoriasis and healthy skin. We identified 889 differentially expressed lncRNAs, many of which with yet unknown functions. RP11‐295G20.2 was identified as a lncRNA significantly induced in psoriasis keratinocytes, and this was verified by qRT‐PCR and by single‐molecule in situ hybridisation. Analysis of subcellular fractions of epidermis revealed a cytoplasmic localisation in line with results of single molecule in situ hybridisation. We report that RP11‐295G20.2 has a skin‐enriched expression, and within skin it is mainly expressed in suprabasal epidermal layers. Moreover, RP11‐295G20.2 is induced by the key psoriasis cytokine IL‐17A and shows a dynamic regulation during keratinocyte differentiation with upregulation during early differentiation and downregulation in the late stage. Knockdown of RP11‐295G20.2 in keratinocytes promotes terminal differentiation. Based on our findings, we named RP11‐295G20.2 Cytoplasmic Differentiation‐Associated Epidermal RNA, CYDAER. In summary, our study provides a comprehensive characterisation of the non‐coding RNA landscape of psoriasis keratinocytes and identifies CYDAER as a skin‐enriched lncRNA regulating keratinocyte differentiation. Our data suggest that overexpression of CYDAER may contribute to altered differentiation in psoriatic epidermis.
Global‐Scale Analysis Reveals Importance of Environment and Species Traits in Spatial Patterns of Riparian Plants' Genetic Diversity
Authors: Surmacz Bartłomiej , Rodríguez González Patricia María , Jansson Roland , Suchan Tomasz , Pielech Remigiusz 
Published: February 2025

ABSTRACTAimIn riparian zones along rivers, plant demography is shaped by hydrologic disturbances, the dendritic structure of the river networks, and asymmetric gene flow due to the prevalence of unidirectional dispersal by hydrochory. Downstream‐biased dispersal may lead to the accumulation of genetic diversity in populations situated lower within the catchment area—a phenomenon referred to as ‘downstream increase in intraspecific genetic diversity’ (DIGD). Our study aimed to test if the presence of this pattern in riparian plants depends on the species traits, sampling design and ecosystem integrity.LocationRiparian zones along rivers worldwide.Time Period1978–2023.Major Taxa StudiedVascular plants.MethodsWe conducted meta‐analysis of population genetic studies on riparian plants to identify the factors linked to the occurrence of the DIGD pattern. We modelled the correlation between position along rivers and population genetic diversity using a dataset consisting of variables extracted from the studies, supplemented by data from plant trait databases.ResultsWe found no evidence for a general trend in plant genetic diversity along rivers, but species traits and environmental factors partially explained the patterns. A downstream increase in genetic diversity was more likely to be found in species capable of hydrochoric dispersal and along the unmodified rivers which maintain habitat continuity.Main ConclusionsOur study highlights that different patterns of genetic diversity can be linked to species traits or different levels of habitat fragmentation. Population genetic studies of riparian plants have frequently investigated patterns of genetic diversity in remnant populations in degraded riparian habitats. Although such investigations are important, more population studies of common plants in well‐preserved riparian zones are needed, as these can help understanding the general mechanisms that control natural population dynamics of plant species.
‘You could start a new country, but you would need to discover new land’: Exploring understandings of statehood with primary school pupils in England
Authors: Saddington Liam , McConnell Fiona 
Published: February 2025

AbstractState‐based imaginaries dominate how children are taught about the world in formal educational spaces. Geographical education in schools draws upon a range of representations from atlases to wall maps, which portray a highly ordered image of a world that is neatly divided up into bounded nation‐states. While scholarship within political geography has long sought to challenge the ‘territorial trap’ which underpins these approaches, and there is increasing awareness and prominence of children's political geography within the subdiscipline, little attention has focused on how children themselves conceptualise and think about the state. This paper aims to contribute to contemporary debates on children's geopolitics and work on the production of geographical knowledge to explore children's understandings of statehood through a focus on English primary school pupils (aged 9–11). We have developed and run an educational activity which addresses the question of ‘what is a country’ and creates space for pupils to critically engage with ideas of statehood. This paper draws upon participation observation of this activity with 441 pupils from 17 classes across 10 state‐maintained primary schools in England. We find that children have complex geopolitical understandings of the world which encompass nuanced articulations of the politics of difference, legitimacy, the act of recognition, and legacies of colonial practices. While the norms of a state‐based international system are firmly established by the end of primary school in the UK, pupils do not merely accept the status quo of the current international system, but can offer nuanced critiques, thinking creatively about different forms the state could take, and engaging with questions of justice and equity. We thereby argue that children should be thought of as critical and creative geopolitical thinkers who can imagine more just and equitable futures.
Who Cares? Gender Differences in Social Reproduction and Well‐Being in South Africa
Authors: Posel Dorrit 
Published: February 2025

ABSTRACTThis paper examines women's responsibility for social reproduction in South Africa. Drawing from a range of studies that analyze quantitative data, it considers how distinctive characteristics of South Africa's socio‐economic landscape shape the nature of this responsibility. These characteristics include rates of paternal coresidence and marriage that are amongst the lowest in the world, unemployment and inequality rates that are amongst the highest, and continuing patterns of individual labor migration with race remaining a significant socio‐economic stratifier. Given these features, women are not only most often the providers of caring labor in the household they are often also the financial providers. Women are responsible for social reproduction even when they are not wives or mothers, and this responsibility limits their access and returns to paid work. Gender asymmetries in who carries the economic costs of social reproduction are highlighted by evidence of both a motherhood earnings penalty and a male marital earnings premium in the South African labor market. In addition to economic measures, the paper reviews research on the noneconomic costs of social reproduction including life satisfaction and depression, and it highlights the importance of recognizing intersectionality in the well‐being of women.
Sexual Harassment and Service Labor: Strategies and Relational Practices
Authors: Farrugia David 
Published: February 2025

ABSTRACTSexual harassment and gender‐based violence are longstanding concerns in studies of service work, but are typically analyzed in terms of interactions between workers and consumers within gendered definitions of “good service,” neglecting the role of relationships amongst workers as a critical context that facilitates or constrains how workers can respond. However, literature on young women and harassment in leisure settings shows that women's safety is an ongoing relational construction—something that women achieve together through relational work. Inspired by these insights and drawing on interviews with service workers, this paper explores how workers respond to sexual harassment from customers, managers and co‐workers, and shows how workers—primarily women but also sometimes men as well—collaborate in managing sexual harassment at work. The paper therefore argues for a relational analysis of the way that women negotiate the gendered and heterosexualized power relationships of service labor.
A New Groundwater Energy Transport Model for the MODFLOW Hydrologic Simulator
Authors: Morway Eric D. , Provost Alden M. , Langevin Christian D. , Hughes Joseph D. , Russcher Martijn J. , Chen Chieh‐Ying , Lin Yu‐Feng F. 
Published: February 2025

AbstractHeat transport in the subsurface is an important aspect of research related to the effects of a warming climate on ecological services (i.e., cold‐water refugia); the development of geothermal resources for energy banking schemes (i.e., aquifer thermal energy storage [ATES]); and the effects of temperature on other aspects of groundwater quality, such as nutrient cycling. Historically, simulation of heat transport using the MODFLOW groundwater simulator and related codes was performed by scaling the input parameters of a solute‐transport model to emulate heat transport. However, that approach required additional pre‐ and post‐processing of input and output and could not account for the variation in effective thermal storage and transport properties during transient, unsaturated flow, for example. True heat‐transport capabilities in the context of MODFLOW were first introduced in a variant called USG‐Transport. More recently, a new groundwater energy‐transport (GWE) model type has been added to MODFLOW 6, the core version of the MODFLOW hydrologic simulator. GWE supports the simulation of heat transport on structured or unstructured grids as well as within and between features of advanced packages that represent streams, lakes, multi‐aquifer wells, and the unsaturated zone. GWE is integrated within MODFLOW 6 and is accessible through the FloPy Python package and the MODFLOW 6 application programming interface (API). An example simulation demonstrates conduction between grid cells through both the water and the solid aquifer material, including thermal bleeding from saturated overburden cells into a groundwater flow field.
Burnout, Stress, and Wellbeing: The Rising Mental Health Crisis in UK Dentistry in Dental Care Professionals. A Quantitative Perspective
Authors: Durkin Jenny , Mumford Ceris 
Published: February 2025

ABSTRACTResearch AimTo determine if dental care professionals working in National Health Service (NHS) practices are more at risk of stress, wellbeing concerns and burnout than their private practice counterparts.IntroductionIn dentistry, stress, anxiety, and wellbeing concerns have been apparent for many years with burnout and poor mental health in dental registrants being described as early as the 1980s.MethodologyAn online platform‐based questionnaire was used to administer the chosen scales. Data from 201 participants were analysed (N = 201). The sample consisted of 31 dental nurses and 170 dental hygienists and dental therapists.Results and ConclusionsA one‐way multivariate analysis of variance (MANOVA) determined that there was no statistically significant difference between private and mixed practice dental professionals on the combined scales F (3, 190) = 0.76, p = 0.59, Wilks Lambda = 0.97, partial eta squared = 0.12. Dental hygienists, dental therapists and dental nurses working in mixed private and NHS dentistry are not more susceptible to stress, wellbeing issues and anxiety than their private counterparts according to the data set. This suggests that there are other factors associated in the mental health concerns of registered dental care professionals raised by the literature examined. The feelings and frustrations of dental registrants are likely to have lasting consequences for the provision of dentistry if working practices and hierarchical conditions do not improve patient access to both private and NHS dentistry. More research into the stress, wellbeing and burnout levels across dental registrants would be beneficial to explore the effects on the entire dental team, with a focus on solely working in NHS provision.
A hybrid protein is a functional molecule to reduce the cytokine storm caused by excessively activated macrophages
Authors: Ikemoto Masaki , Kotani Takuya , Okada Kohki , Matsuda Shogo , Takeuchi Tohru 
Published: February 2025

AbstractWe recently developed a hybrid protein, tentatively named human MIKO‐1 (hMIKO‐1), based on the amino acid sequences of human S100A8 (hS100A8) and hS100A9. Human THP‐1 macrophages (THP‐1m), differentiated from THP‐1 cells by phorbol 12‐myristate 13‐acetate, were used to investigate the immune function of hMIKO‐1 as a drug for inflammatory diseases. Western blotting was conducted to confirm whether hMIKO‐1 binds with β‐actin and nuclear factor‐kappa B to form complexes in THP‐1m. A polymerase chain reaction (PCR) and quantitative PCR were performed to examine changes in the messenger RNA levels of proinflammatory cytokines in THP‐1m. Fluorescent immunochemical staining was used to observe the intracellular localization of hMIKO‐1 and hS100A8 or hS100A9 in THP‐1m. As observed microscopically, the intracellular localization of hMIKO‐1 in THP‐1m was consistent with that of hS100A8, suggesting the close involvement of hS100A8 in the intracellular behavior of hMIKO‐1 in THP‐1m. Western blotting revealed that hMIKO‐1 formed complexes with intracellular proteins, such as β‐actin and nuclear factor‐kappa B, to negatively regulate inflammatory signal transduction in THP‐1m. Flow cytometry showed that the binding of hMIKO‐1 to THP‐1m significantly decreased when THP‐1m were preliminarily treated with a sialidase (neuraminidases) cocktail. Therefore, the present results strongly suggest that the binding of hMIKO‐1 to THP‐1m closely involves the sugar chains of the surface proteins of cells. The messenger RNA expression of each proinflammatory cytokine was significantly suppressed in THP‐1m preliminarily treated with hMIKO‐1 despite a subsequent stimulation with lipopolysaccharide. In conclusion, hMIKO‐1 is a functional molecule that significantly inhibits inflammatory signal transduction in THP‐1m.
The Acceptability of Psychedelic‐Assisted Therapy Amongst Mental Health Consumers: Utilising the Theory of Planned Behaviour
Authors: Louie Eva , Towers Ellen , Morse Alyssa R. , Watt Joshua , Bryant Zachary , Haber Paul , Morley Kirsten 
Published: February 2025

ABSTRACTAustralian government approval has been granted for 3,4‐methylenedioxy‐methamphetamine (MDMA) treatment of post‐traumatic stress disorder and psilocybin for treatment‐resistant depression, but the process of translating psychedelic‐assisted therapies (PAT) into more widespread use is complex. Along with establishing the efficacy and feasibility of PATs, their acceptability amongst consumers is a crucial factor of successful implementation. This study utilised the Theory of Planned Behaviour to evaluate the acceptability of PATs amongst mental health consumers, identifying potential influences of these attitudes and predictors of PAT uptake. Participants completed an online survey between February and July 2023. Survey items evaluated consumer characteristics, acceptability of PAT (effectiveness, efficacy and social norms) and behavioural intentions to undertake PAT. The 254 participants had a mean age of 42.5 years (SD = 12.8) and 79.1% were female. Three quarters expressed a desire to access PAT. Acceptability scores indicated strong agreement regarding the effectiveness of PAT, social norms that moderately endorsed PAT and mixed feelings about its expected efficacy. Whilst univariate analyses indicated that previous psychedelic experience was associated with increased acceptability of PAT (ds = 0.63–0.80), multivariate analyses revealed that intentions to access PAT were associated with higher acceptability scores (ds = 0.37–1.32) and poorer experiences of conventional therapy (d = −0.31). Although a relatively large portion of participants had used psychedelics recreationally, the desire to access PATs was more strongly related to its acceptability, along with more negative experiences of conventional therapy. This implies that mental health consumers who are looking for alternatives to conventional therapy may view PATs as a desirable option, despite some safety reservations.
Imaginative Interdependence: Imagination, Speculation and Aesthesis
Authors: Atkinson Dennis 
Published: February 2025

AbstractThis paper addresses the importance of creativity, speculative imagination and the production of novelty in pedagogic practices in art education and art practice. These terms refer to always incomplete assemblages or agencements of experiencing. Whitehead's ideas on imagination, speculation and propositions are linked with Stengers's work on speculation and the cosmic adventure. The paper proceeds to consider the notion of imaginative interdependence as a key leitmotif, illustrated by Haraway's (2016, p. 14) discussion of the children's game ‘cats cradle.’ Imaginative interdependence is then aligned with the notion of ‘agencement’ to move away from viewing practice or imagination as processes initiated by a prior or transcendent subjectivity, what we might call the phenomenological subject. In contrast, practice and imagination are conceived as emerging within agencements, interdependent relations, considered as cosmic adventures often involving human and non‐human participants. Such adventures are explored and problematised in the context of art education. Questions arise involving the contrast between the dispositifs of institutionalised art education and local agencements of art practice that may not conform. The notion of aesthesis is introduced to explore these contrasts as well as that pertaining to the contrast between established conventions of art education and the rupturing force of art's education that may open new modes of sensing and becoming. To conclude the paper builds upon the notion of agencements of imaginative interdependence in the context of art education by emphasising the importance of aesthesis and Deleuze and Guattari's call for a new earth and a people to come.