bluuebunny/crossref_metadata_2025_split huggingface dataset:
Screening of potential antioxidant bioactive Q-markers of paeoniae radix rubra based on an integrated multimodal strategy
Authors: Li Hengli , Zhao Yu , Wang Jiaqi , Peng Caiwang , Tang Keyan , Sun Mu , Yang Yantao , Liu Qingping , Liu Fang 
Published: August 2024

BackgroundPaeoniae Radix Rubra (PRR) has been used widely to promote blood circulation and eliminate blood stasis in China clinical practice owing to its extensive pharmacological effects. However, the “quality markers” (Q-markers) of the antioxidant effects remains unknown.ObjectTo explore the Q-markers of antioxidant activity based on multiple strategies, which would provide reference for the quality evaluation of PRR based on specific pharmacodynamic-oriented.MethodsFirstly, the “fingerprint” profiles of 15 batches of PRR were acquired and identified by ultrahigh performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-Q-TOF MS/MS) and the common peaks extracted. Meanwhile, the MTT assay was used to evaluate the effect of 15 batches of PRR on H2O2-induced oxidative stress in HT-22 cells. The antioxidant activity of PRR was investigated simultaneously by superoxide dismutase (SOD), glutathione (GSH), and malondialdehyde (MDA) commercial kits. The relationship between common peaks and antioxidant indexes were constructed by grey relational analysis (GRA) and partial least squares-discriminant analysis (PLS-DA) for the identification of preselected Q-markers. Secondly, experimental verification was conducted to investigate the protective effect of the preliminary components on HT-22 cells undergoing oxidative stress. Finally, for the further validation of effectiveness of antioxidant Q-markers, network pharmacology was applied to explore potential targets, and the molecular docking technology was used to value the binding ability of the potential active components of PRR to the antioxidant targets.ResultsThirty-seven common peaks from 15 batches of PRR were identified qualitatively by UHPLC-Q-TOF MS/MS. The MTT assay showed that PRR could reduce the oxidative damage induced by H2O2 upon HT-22 cells according to the index of MDA, SOD and GSH. Eight potential antioxidant components were screened by spectrum-effect correlation analysis: paeoniflorin, galloylpaeoniflorin, albiflorin, 1,2,3,4,6-o-pentagalloylglucose, benzoylpaeoniflorin, pinocembrin, oleanic acid, and isorhamnetin-3-o-nehesperidine. Each of these preliminary components showed significant protections on cellular oxidative stress (P &lt; 0.05). Interleukin-6 (IL-6), protein kinase B (AKT1), and tumor necrosis factor (TNF) were predicted to be the major potential targets of PRR, and the good binding ability were presented between the potential active components of PRR and each target as a whole.ConclusionEight components were identified as the antioxidant Q-markers of PRR based on an integrated multimodal strategy.
SPECT/CT to quantify early small airway disease and its relationship to clinical symptoms in smokers with normal lung function: a pilot study
Authors: Juneau Daniel , Leblond Antoine , Chatta Rami , Lévesque Valérie , Lussier Annabelle , Dubé Bruno-Pierre 
Published: August 2024

IntroductionSmokers frequently display respiratory symptoms despite the fact that their pulmonary function tests (PFTs) can be normal. Quantitative lung ventilation single-photon emission computed tomography (SPECT/CT) can provide a quantification of lung ventilatory homogeneity and could prove useful as an early marker of airway disease in smokers. We measured the effects of smoking on regional ventilation distribution in subjects with normal lung function and evaluated whether ventilation distribution in these subjects is related to lung function tests results and clinical symptoms.MethodsSubjects without any history of respiratory disease were prospectively recruited and separated in two groups: active smokers (AS: ≥10 cigarettes/day and history of ≥15 pack-years) and never smokers (NS: lifetime exposure of &lt;5 cigarettes). All subjects performed PFTs (which had to be normal, defined as z-score values of forced expiratory volume in 1 s (FEV1), forced vital capacity (FVC), FEV1/FVC ratio, total lung capacity (TLC) residual volume and diffusion capacity (DLCO) all falling between −1.65 and +1.65) and underwent SPECT/CT with Technegas, which generated subject- specific ventilation heterogeneity maps. The area under the compensated coefficient of variation (CV) density curve for CV values &gt; 40%, (AUC-CV40%) was used as the measure of ventilation heterogeneity.Results30 subjects were recruited (15 per group). Subjects in the AS group displayed higher dyspnea levels (1 [1–2] vs. 0 [0–1] units on mMRC scale, p &lt; 0.001). AUC- CV40% was significantly higher in the AS group (0.386 ± 0.106 vs. 0.293 ± 0.069, p = 0.004). AUC-CV40% was significantly correlated to FEV1 (rho = −0.47, p = 0.009), DLCO (rho = −0.49, p = 0.006), CAT score (rho = 0.55, p = 0.002) and mMRC score (rho = 0.54, p = 0.002). Subjects with mMRC &gt;0 had higher AUC-CV40% values than those without dyspnea (0.289 ± 0.071 vs. 0.378 ± 0.102, p = 0.006), while FEV1 and DLCO were not different between those groups. ROC analyses showed that the AUC for AUC-CV40% in identifying subjects with mMRC score &gt;0 was 0.78 (95%CI 0.61–0.95, p = 0.009), which was significantly higher than that of FEV1 and DLCO.DiscussionIn smokers with normal lung function, ventilatory inhomogeneities can be quantified using SPECT/CT. AUC-CV40% values are related to lung function decline and to respiratory symptomatology, suggesting a potential role for this marker in the evaluation of symptomatic smokers.
Wavelet-based U-shape network for bioabsorbable vascular stents segmentation in IVOCT images
Authors: Lin Mingfeng , Lan Quan , Huang Chenxi , Yang Bin , Yu Yuexin 
Published: August 2024

Background and ObjectiveCoronary artery disease remains a leading cause of mortality among individuals with cardiovascular conditions. The therapeutic use of bioresorbable vascular scaffolds (BVSs) through stent implantation is common, yet the effectiveness of current BVS segmentation techniques from Intravascular Optical Coherence Tomography (IVOCT) images is inadequate.MethodsThis paper introduces an enhanced segmentation approach using a novel Wavelet-based U-shape network to address these challenges. We developed a Wavelet-based U-shape network that incorporates an Attention Gate (AG) and an Atrous Multi-scale Field Module (AMFM), designed to enhance the segmentation accuracy by improving the differentiation between the stent struts and the surrounding tissue. A unique wavelet fusion module mitigates the semantic gaps between different feature map branches, facilitating more effective feature integration.ResultsExtensive experiments demonstrate that our model surpasses existing techniques in key metrics such as Dice coefficient, accuracy, sensitivity, and Intersection over Union (IoU), achieving scores of 85.10%, 99.77%, 86.93%, and 73.81%, respectively. The integration of AG, AMFM, and the fusion module played a crucial role in achieving these outcomes, indicating a significant enhancement in capturing detailed contextual information.ConclusionThe introduction of the Wavelet-based U-shape network marks a substantial improvement in the segmentation of BVSs in IVOCT images, suggesting potential benefits for clinical practices in coronary artery disease treatment. This approach may also be applicable to other intricate medical imaging segmentation tasks, indicating a broad scope for future research.
The association between diverse psychological protocols and the efficacy of psilocybin-assisted therapy for clinical depressive symptoms: a Bayesian meta-analysis
Authors: Chen Mu-Hong , Cheng Shu-Li , Kao Yu-Chen , Tseng Ping-Tao , Hsu Chih-Wei , Yu Chia-Ling , Yang Fu-Chi , Thompson Trevor , Hsu Tien-Wei , Liang Chih-Sung 
Published: August 2024

ObjectivePsilocybin-assisted therapy has shown promising efficacy on clinical depressive symptoms. However, diverse psychological support or psychotherapy was performed with psilocybin treatment. This study aimed to explore the association of psychological protocols with the efficacy of psilocybin-assisted therapy for depressive symptoms.MethodFive major databases were systemic searched for clinical trials addressing psilocybin-assisted therapy for patients with clinical depressive symptoms. A Bayesian random-effects meta-analysis and meta-regression were performed. The effect size was mean difference (with 95% credible interval) measured by 17-Item Hamilton Depression Rating Scale.ResultsThere were 10 eligible studies including 515 adult patients with clinically diagnosed depression. The psychological protocols could be categorized into four types: (i) manualized directive psychotherapy(k=1); (ii) manualized nondirective psychological support(k=3), (iii) non-manualized nondirective psychological support(k=5); and (iv) non-manualized supportive psychotherapy(k=1). The pooled standard mean difference of psilocybin-assisted therapy was 10.08 (5.03-14.70).ConclusionCompared with manualized nondirective psychological support, the other three psychological approaches did not differ significantly. The improvement of depressive symptoms was not associated with the psychological protocols in adult patients receiving psilocybin-assisted therapy.Systemic review registrationOpen Science Framework: identifier (osf.io/3YUDV).
“Why would we?” A qualitative study on COVID-19 vaccination decision making among Ukrainian economic female migrants in Poland
Authors: Ganczak Maria , Kalinowski Pawel , Twardowski Piotr , Osicka Dominika A. , Pasek Oskar , Duda-Duma Łukasz , Vervoort Johanna P. M. , Edelstein Michael , Kowalska Marta 
Published: August 2024

BackgroundUkraine has one of the lowest COVID-19 vaccination rates in Europe. This may pose a significant epidemiological risk in the context of the refugee crisis and the fact that, since 2020, SARS-CoV-2 has been spreading and changing globally.ObjectiveTo evaluate determinants of vaccination decision making among Ukrainian female migrants (UFMs).MethodsA qualitative study with 45 UFMs was conducted between December 2021 and January 2022. UFMs, from 2 Polish provinces, differing in age, education and length of stay were invited with the use of the snowball technique. Using a semi-structured topic guide, eight focus groups were conducted in person, recorded and transcribed. Thematic, qualitative analysis was made; key themes which emerged from the data (with the help of the Working Group Determinants of Vaccine Hesitancy Matrix), were related to contextual, individual/group and contextual vaccine/vaccination-specific influences.ResultsMothers were found to be playing a crucial role in children and adolescent COVID-19 vaccine decision-making process. Universal trust in the Polish healthcare system and vaccination procedures, employer requirements and willingness to preserve jobs, desire to get back to normal and social influences were paramount prerequisites to let UFMs make a decision to get vaccinated. However, COVID-19 vaccines also faced backlash among UFMs. Negative experiences with vaccines provided in Ukraine, doubts about the rapid vaccine development, combined with lack of confidence in vaccine safety, specifically regarding child vaccination, might have a bearing on UFMs’ decision about declining COVID-19 vaccine while on migration. Discrimination through HCWs during vaccination visits was also reported. Corrupted Ukrainian healthcare system, which facilitates proof forgery regarding vaccination certificates, could act as a negative influencer of UFMs’ vaccine decision-making.ConclusionThe results provide the novel information, expressed in economic UFMs’ own words. Findings show that influencers of the decision-making process regarding the COVID-19 vaccination are complex and polarized; elements of hesitancy may persist after migration. Any continuation of UFMs’ vaccination with COVID-19 vaccine should be subject to designing accessible information to address modifiable demotivators of the vaccine decision-making process identified in this study.
The willingness to use internet-based home care services and its influencing factors among rural older people in Henan Province, China: a cross-sectional study
Authors: Yan Yuwen , Zhang Yan , Zhang Huizhong , Li Xizheng , Meng Lixue , Tian Yutong 
Published: August 2024

BackgroundTo meet the growing health needs of older people, the Chinese government has introduced internet-based home care services. However, most rural older people have not yet benefited from such services, and the willingness to use these services and the factors influencing them remain unclear.ObjectiveWe aim to investigate the current willingness of rural older people to use internet-based home care services and analyze the factors.MethodsWe conducted a cross-sectional study across multiple centers using general information and self-developed questionnaires. Qualitative interviews, a literature review and the Delphi method were employed to develop the questionnaire. A total score of the questionnaire above 78 or higher indicates a high willingness to use internet-based home care services. Descriptive statistics, t-tests, one-way ANOVA, and multiple linear regression were used to explore the factors that influence the willingness of rural older people to use internet-based home care services.ResultsWe surveyed 349 rural older people. The total score of rural older people’s willingness to use internet-based home care services was 84.49 ± 10.88, indicating high willingness, with the highest score for the dimension of perceived usefulness and lower scores for the dimension of perceived ease of use. Multiple linear regression analysis revealed that gender, education level, residence status, number of chronic diseases, and knowledge of internet-based home care services were the most important factors for rural older people (all p &lt; 0.05).ConclusionThe willingness of rural older people to use internet-based home care services is high. Thus, it is recommended that county hospitals increase public awareness of such services, optimize the design of their interfaces, and support family and social resources from relevant departments that can maximize access, so as to provide a reference for later relevant departments to enhance willingness.
The relationship between off-ice testing and on-ice performance in male youth Ice hockey players
Authors: Rice Mark S. , Warburton Darren E. R. , Gaytan-Gonzalez Alejandro , Jamnik Veronica K. , Kaufman Kai , Warburton Declan R. D. , Souster Michael , Bredin Shannon S. D. 
Published: August 2024

IntroductionIce hockey demands a unique blend of physical fitness and skill, necessitating a comprehensive understanding of the factors influencing on-ice performance. The present study was designed to examine the relationship between off-ice and on-ice performance measures in male, youth, ice hockey players.MethodsEleven minor hockey players (Age = 9.8 ± 1.1 years) participated in two testing days: (1) off-ice and (2) on-ice assessments. Off-ice assessments included maximal aerobic power, anaerobic fitness, muscular strength (handgrip and single leg squat), muscular endurance (curl-ups and push-ups), muscular power (standing long jump and vertical jump), and 30 m sprinting speed and acceleration. On-ice testing included a 15.2 m maximum speed test, a 6.1 m acceleration test with a continuation into a 47.9 m top speed test, an agility cornering S turn test, and a shot velocity test.ResultsTwenty-four out of 33 off-ice variables were significantly correlated with at least one of the 11 on-ice performance variables. From those 24, 10 were included as predictors for at least one of the on-ice performance variables. Each model was composed of either one or two predictors, where the most common predictors were 30 m Run – Split (6.1 m) Sprint time and 30 m Run – Total (30 m) Sprint Max speed (included in four out of 11 models each). The prediction formulas R2 and coefficient of variation ranged from 0.63% to 0.96% and 1.2% to 15.3%, respectively.DiscussionDiverse off-ice measures of aerobic fitness, anaerobic power, muscular strength, power, and endurance, and sprinting speed, acceleration, and agility are predictive of on-ice performance. The insights gained from this study contribute to the refinement of assessment protocols, fostering a comprehensive approach to optimizing player performance and potential. Understanding the connection between objective off-ice testing and on-ice performance can support tailored training programs and player development in male youth ice hockey.
Formulation of a Three-Component Essential Oil Mixture from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis for Improved Antioxidant Activity
Authors: Elbouzidi Amine , Taibi Mohamed , El Hachlafi Naoufal , Haddou Mounir , Jeddi Mohamed , Baraich Abdellah , Aouraghe Aya , Bellaouchi Reda , Mothana Ramzi A. , Hawwal Mohammed F. , Mesnard François , Hano Christophe , Asehraou Abdeslam , Chaabane Khalid , El Guerrouj Bouchra , Addi Mohamed 
Published: August 2024

The optimization of existing natural antioxidants that are highly effective is crucial for advancements in medicine and the food industry. Due to growing concerns regarding the safety of synthetic antioxidants, researchers are increasingly focusing on natural sources, particularly essential oils (EOs). Combining EOs might enhance antioxidant activity due to increased chemical diversity. This study investigates, for the first time, the antioxidant properties of EOs from Lavandula dentata, Rosmarinus officinalis, and Myrtus communis, both individually and in combination, using the augmented-simplex design methodology. The in vitro evaluation of the antioxidant activity was performed using DPPH and ABTS radical scavenging assays. Chromatography gas-mass spectrometry (CG-MS) revealed that 1,8-cineol (37.27%) and pinocarveol (12.67%) are the primary components of L. dentata; verbenone (16.90%), camphor (15.00%), and camphene (11.03%) are predominant in R. officinalis; while cineol (43.32%) is the main component of M. communis. The EOs showed varying scavenging activities against ABTS and DPPH radicals, with DPPH assay values ranging from 194.10 ± 3.01 to 541.19 ± 3.72 µg/mL and ABTS assay values ranging from 134.07 ± 1.70 to 663.42 ± 2.99 µg/mL. These activities were enhanced when the EOs were combined. The optimal antioxidant blend for DPPHIC50 consisted of 20% L. dentata, 50% R. officinalis, and 30% M. communis. For the highest ABTS radical scavenging activity, the best combination was 18% L. dentata, 43% R. officinalis, and 40% M. communis. These results highlight the potential of EO combinations as new natural formulations for use in cosmeceutical, food, and pharmaceutical sectors.
Bypass ou Sleeve: considerações quanto à escolha do método de cirurgia bariátrica
Authors: Silveira Henrique Fernandes , Pelegrini João Paulo de Araújo , Bianchini Maria Passos 
Published: August 2024

Introdução: A obesidade caracteriza uma epidemia em todo o mundo, e a cirurgia bariátrica é considerada o tratamento mais efetivo a longo prazo para obesidade grave, em comparação ao tratamento clínico. As duas técnicas bariátricas mais realizadas são o Bypass e o Sleeve. Várias questões devem ser avaliadas quando se trata na escolha do método de cirurgia bariátrica. Objetivo: O objetivo deste estudo é evidenciar vantagens e desvantagens de cada um destes métodos, a fim de basear a discussão para a melhor escolha para cada paciente. Métodos: Este estudo configura uma revisão de literatura, baseada em artigos científicos de maior importância. Discussão: o Sleeve ganhou popularidade rapidamente, e, em 2014, se tornou o procedimento bariátrico mais realizado no mundo, porém possui suas contraindicações. O Bypass ainda é considerado padrão ouro, uma vez que induz uma maior perda de peso a longo termo em comparação ao Sleeve, mas também possui suas desvantagens. Independentemente do procedimento escolhido, o paciente pode esperar um reganho fisiológico do peso com o passar do tempo, que se inicia geralmente após dois anos do procedimento, o que não caracteriza uma falha do tratamento. Conclusão: Não existe o melhor procedimento para todos os pacientes. Deve-se entender os riscos e benefícios de cada um dos métodos, além das contraindicações de cada um. Portanto, a escolha do procedimento a ser realizado deve ser baseada em pilares científicos e sociais, sendo sempre individualizado para cada paciente.
Ruptura esplênica espontânea em paciente com Dengue
Authors: Silveira Henrique Fernandes , Pelegrini João Paulo de Araújo , Penna Lucas Gonçalves Soares Drummond 
Published: August 2024

Introdução: A dengue é uma infecção viral transmitida aos humanos por meio de picadas de mosquitos infectados. Possui um grande espectro de manifestações clínicas, onde a maioria dos pacientes é assintomática. Em alguns casos pode progredir para febre hemorrágica e síndrome do choque da dengue. Objetivo: Relatar o caso de um paciente com diagnóstico de dengue e sem fatores agravantes da doença, que evoluiu para quadro de dengue hemorrágica, necessitando de conduta cirúrgica para resolução e tratamento adequado. Metodologia: Relato de caso, baseado em prontuário, exames de imagem e em artigos científicos, encontrados principalmente via PubMed e Scielo, utilizando termos como “dengue”, “ruptura esplênica espontânea” e “febre hemorrágica da dengue”. Critérios de inclusão envolvem artigos que possuíam informações relevantes sobre o tema e confrontações importantes do diagnóstico e desfecho clínico dos pacientes com ruptura esplênica após infecção pela dengue. Discussão: A ruptura esplênica pode ser de origem traumática ou não traumática. Quanto à ruptura esplênica espontânea, de origem não traumática, os fatores mais associados são: infecções, malignidade, doenças hematológicas, disfunções metabólicas e doenças vasculares. Nos casos de dengue, a ruptura esplênica espontânea é uma complicação grave e rara, podendo se manifestar tanto na forma de Dengue Clássica, quanto na forma de Dengue Hemorrágica, como no caso apresentado. Conclusão: Determinar as complicações hemorrágicas da dengue e avaliar necessidade de intervenção precoce para uma adequada resolução, a exposição desse relato de caso tem a finalidade de reforçar o diagnostico precoce nos casos de ruptura visceral e exemplificar um desfecho positivo frente a um quadro grave de dengue hemorrágica devido a ruptura esplênica não traumática.