bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wear‐resistant cotton fabrics modified by PU coatings prepared via mist polymerization
Authors: Fan Wanchao , Zhu Yanhui , Xi Guanghui , Huang Meiqi , Liu Xiang Dong 
Published: October 2015

ABSTRACTCotton fabric was successfully modified using a simple mist polymerization with polyurethane (PU) prepolymer and ethylene glycol as the monomers. Scanning electron microscope showed the presence of a very thin polymer coating on the cotton fiber surface. Martindale abrasion tests revealed that the thin PU coating imparted to the cotton fabric a doubled wearing durability compared with the original fabric. Additional experiments demonstrated that the mist polymerization has little impact on the desired cotton properties such as water absorptivity, vapor transmissibility, mechanical property, and flexibility. Considering the excellent balance between the enhanced abrasion resistance and the cotton natures, this surface modification methodology has potential to fabricate wearing durable textiles. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci.2016,133, 43024.
G‐Tetraplex‐Induced FRET within Telomeric Repeat Sequences Using PyA‐PerA as Energy Donor–Acceptor Pair
Authors: Kundu Rajen 
Published: October 2015

AbstractG‐tetraplex induced fluorescence resonance energy transfer (FRET) within telomeric repeat sequences has been studied using a nucleoside‐tethered FRET pair embedded in the human telomeric G‐quadruplex forming sequence (5′‐A GGG TTPyA GGG TTPerA GGG TTA GGG‐3′, Py=pyrene, Per=perylene). Conformational change from a single strand to an anti‐parallel G‐quadruplex leads to FRET from energy donor (PyA) to acceptor (PerA). The distance between the FRET donor/acceptor partners was controlled by changing the number of G‐quartet spacer units. The FRET efficiency decreases with increase in G‐quartet units. Overall findings indicate that this could be further used for the development of FRET‐based sensing and measurement techniques.
Probing the reaching–grasping network in humans through multivoxel pattern decoding
Authors: Di Bono Maria Grazia , Begliomini Chiara , Castiello Umberto , Zorzi Marco 
Published: October 2015

AbstractIntroductionThe quest for a putative human homolog of the reaching–grasping network identified in monkeys has been the focus of many neuropsychological and neuroimaging studies in recent years. These studies have shown that the network underlying reaching‐only and reach‐to‐grasp movements includes the superior parieto‐occipital cortex (SPOC), the anterior part of the human intraparietal sulcus (hAIP), the ventral and the dorsal portion of the premotor cortex, and the primary motor cortex (M1). Recent evidence for a wider frontoparietal network coding for different aspects of reaching‐only and reach‐to‐grasp actions calls for a more fine‐grained assessment of the reaching–grasping network in humans by exploiting pattern decoding methods (multivoxel pattern analysis—MVPA).MethodsHere, we used MPVA on functional magnetic resonance imaging (fMRI) data to assess whether regions of the frontoparietal network discriminate between reaching‐only and reach‐to‐grasp actions, natural and constrained grasping, different grasp types, and object sizes. Participants were required to perform either reaching‐only movements or two reach‐to‐grasp types (precision or whole hand grasp) upon spherical objects of different sizes.ResultsMultivoxel pattern analysis highlighted that, independently from the object size, all the selected regions of both hemispheres contribute in coding for grasp type, with the exception of SPOC and the right hAIP. Consistent with recent neurophysiological findings on monkeys, there was no evidence for a clear‐cut distinction between a dorsomedial and a dorsolateral pathway that would be specialized for reaching‐only and reach‐to‐grasp actions, respectively. Nevertheless, the comparison of decoding accuracy across brain areas highlighted their different contributions to reaching‐only and grasping actions.ConclusionsAltogether, our findings enrich the current knowledge regarding the functional role of key brain areas involved in the cortical control of reaching‐only and reach‐to‐grasp actions in humans, by revealing novel fine‐grained distinctions among action types within a wide frontoparietal network.
Streamlining the learning process for TAVI: Insight from a comparative analysis of the OCEAN‐TAVI and the massy registries
Authors: Inohara Taku , Hayashida Kentaro , Watanabe Yusuke , Yamamoto Masanori , Takagi Kensuke , Yashima Fumiaki , Arai Takahide , Shimizu Hideyuki , Chevalier Bernard , Lefèvre Thierry , Fukuda Keiichi , Morice Marie‐Claude 
Published: October 2015

BackgroundsTo facilitate the learning process of transcatheter aortic valve implantation (TAVI) in Japan, unique supporting systems (e.g., on‐site proctor and web‐based screening systems) have been developed. Nevertheless, little is known about real‐world clinical outcomes after TAVI in Japan compared with their European counterparts.MethodsFrom the optimized catheter valvular intervention (OCEAN‐TAVI, Japan) and the Institut Cardiovasculaire Paris Sud (Massy, France) registries, we evaluated a total of 134 and 178 patients, respectively, who underwent transfemoral TAVI during the same time period.ResultsAmong the French cohort, about half of the patients (N = 81, 45.5%) were treated with the Edwards SAPIEN XT. Body surface area was significantly smaller in the Japanese cohort, although operative risks for both cohorts were almost the same. A greater percentage of patients in the Japanese cohort were implanted with 23 mm valves compared with the French cohort (73.1% vs. 23.0%, P < 0.001), reflecting the smaller annulus diameter (21.8 ± 1.6 vs. 23.8 ± 2.4 mm, P < 0.001). All‐cause 30‐day mortality (0% vs. 0.6%, P = 1.000) and 30‐day combined safety endpoint based on the Valve Academic Research Consortium 2 (VARC2) criteria (9.7% vs. 11.2%, P = 0.713) were similar when limiting the analysis to patients treated with the Edwards SAPIEN XT.ConclusionsDespite the unfavorable aortic anatomy of the Japanese patients, their clinical outcomes after transfemoral TAVI were excellent with the same degree of safety as in an experienced European institute. This minimized learning process achieved the use of unique support systems. © 2015 Wiley Periodicals, Inc.
Spontaneous remission in three cases of AML M5 with NPM1 mutation
Authors: Camus Vincent , Etancelin Pascaline , Jardin Fabrice , Lenain Pascal , Contentin Nathalie , Daliphard Sylvie , Buchonnet Gérard , Lemasle Emilie , Lanic Hélène , Leprêtre Stéphane , Penther Dominique , Dubois Sydney , Tilly Hervé , Bastard Christian , Stamatoullas Aspasia 
Published: October 2015

Key Clinical MessagePatients with NPM1‐mutated AML M5 who develop spontaneous remission (SR) after antibiotic therapy at diagnosis seem to form a favorable prognosis and chemo sensitive subtype. We report three cases of AML M5 patients with the same genotype that experienced transient SR and are now leukemia free after standard treatment.
Ultrafine Fe3O4 Quantum Dots on Hybrid Carbon Nanosheets for Long‐Life, High‐Rate Alkali‐Metal Storage
Authors: Liu Shaohong , Wang Yuwei , Dong Yanfeng , Zhao Zongbin , Wang Zhiyu , Qiu Jieshan 
Published: October 2015

AbstractOne promising and economic step towards technological advancements in Na‐ion and Li‐ion batteries is to develop versatile electrode materials for alkali‐metal storage. Transitional‐metal oxides are appealing candidates, owing to their intrinsically low cost, high capacity, and enhanced safety. However, they generally show poor activity and a short lifespan in practical use. Herein, we report the fabrication of a versatile long‐life, high‐rate anode material for Li/Na storage by strongly binding ultrafine Fe3O4 quantum dots onto hybrid carbon nanosheets. Such nanocomposites are advantageous for inhibiting particle aggregation, reducing ionic diffusion pathways, and enabling fast accessibility to electrolyte ions across large electrode–electrolyte interfaces. They exhibit a long lifetime of 1000 cycles, high capacities, and exceptional high rate capabilities towards alkali‐metal storage, highlighting great promise in high‐energy and high‐power energy applications.
Carbon‐Dot‐Sensitized, Nitrogen‐Doped TiO2 in Mesoporous Silica for Water Decontamination through Nonhydrophobic Enrichment–Degradation Mode
Authors: Cheng Chen , Tan Xianjun , Lu Deli , Wang Lingzhi , Sen Tapas , Lei Juying , El‐Toni Ahmed Mohamed , Zhang Jinlong , Zhang Fan , Zhao Dongyuan 
Published: October 2015

AbstractMesoporous silica synthesized from the cocondensation of tetraethoxysilane and silylated carbon dots containing an amide group has been adopted as the carrier for the in situ growth of TiO2 through an impregnation–hydrothermal crystallization process. Benefitting from initial complexation between the titania precursor and carbon dot, highly dispersed anatase TiO2 nanoparticles can be formed inside the mesoporous channel. The hybrid material possesses an ordered hexagonal mesostructure with p6mm symmetry, a high specific surface area (446.27 m2 g−1), large pore volume (0.57 cm3 g−1), uniform pore size (5.11 nm), and a wide absorption band between λ=300 and 550 nm. TiO2 nanocrystals are anchored to the carbon dot through TiON and TiOC bonds, as revealed by X‐ray photoelectron spectroscopy. Moreover, the nitrogen doping of TiO2 is also verified by the formation of the TiN bond. This composite shows excellent adsorption capabilities for 2,4‐dichlorophenol and acid orange 7, with an electron‐deficient aromatic ring, through electron donor–acceptor interactions between the carbon dot and organic compounds instead of the hydrophobic effect, as analyzed by the contact angle analysis. The composite can be photocatalytically recycled through visible‐light irradiation after adsorption. The narrowed band gap, as a result of nitrogen doping, and the photosensitization effect of carbon dots are revealed to be coresponsible for the visible‐light activity of TiO2. The adsorption capacity does not suffer any clear losses after being recycled three times.
Extending the Scope of the B(C6F5)3‐Catalyzed CN Bond Reduction: Hydrogenation of Oxime Ethers and Hydrazones
Authors: Mohr Jens , Porwal Digvijay , Chatterjee Indranil , Oestreich Martin 
Published: October 2015

AbstractThe B(C6F5)3‐catalyzed hydrogenation is applied to aldoxime triisopropylsilyl ethers and hydrazones bearing an easily removable phthaloyl protective group. The CN reduction of aldehyde‐derived substrates (oxime ethers and hydrazones) is enabled by using 1,4‐dioxane as the solvent known to participate as the Lewis‐basic component in FLP‐type heterolytic dihydrogen splitting. More basic ketone‐derived hydrazones act as Lewis bases themselves in the FLP‐type dihydrogen activation and are therefore successfully hydrogenated in nondonating toluene. The difference in reactivity between aldehyde‐ and ketone‐derived substrates is also reflected in the required catalyst loading and dihydrogen pressure.
Enantioselective Addition of Diethylzinc to Aldehydes Catalyzed by Chiral O,N,O‐tridentate Phenol Ligands Derived From Camphor
Authors: Lee Dong‐Sheng , Chang Shu‐Ming , Ho Chun‐Ying , Lu Ta‐Jung 
Published: October 2015

AbstractChiral O,N,O‐tridentate phenol ligands bearing a camphor backbone were found to be effective chiral catalysts for the enantioselective addition of diethylzinc to aromatic aldehydes, resulting in high enantioselectivities (80–95% ee) at room temperature. Chirality 28:65–71, 2016. © 2015 Wiley Periodicals, Inc.
A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation
Authors: Scarpelli Rita , Sasso Oscar , Piomelli Daniele 
Published: October 2015

AbstractPain states that arise from non‐resolving inflammation, such as inflammatory bowel disease or arthritis, pose an unusually difficult challenge for therapy because of the complexity and heterogeneity of their underlying mechanisms. It has been suggested that key nodes linking interactive pathogenic pathways of non‐resolving inflammation might offer novel targets for the treatment of inflammatory pain. Nonsteroidal anti‐inflammatory drugs (NSAIDs), which inhibit the cyclooxygenase (COX)‐mediated production of pain‐ and inflammation‐inducing prostanoids, are a common first‐line treatment for this condition, but their use is limited by mechanism‐based side effects. The endogenous levels of anandamide, an endocannabinoid mediator with analgesic and tissue‐protective functions, are regulated by fatty acid amide hydrolase (FAAH). This review outlines the pharmacological and chemical rationale for the simultaneous inhibition of COX and FAAH activities with designed multitarget agents. Preclinical studies indicate that such agents may combine superior anti‐inflammatory efficacy with reduced toxicity.
Reduced prefrontal activation during working and long‐term memory tasks and impaired patient‐reported cognition among cancer survivors postchemotherapy compared with healthy controls
Authors: Wang Lei , Apple Alexandra C. , Schroeder Matthew P. , Ryals Anthony J. , Voss Joel L. , Gitelman Darren , Sweet Jerry J. , Butt Zeeshan A. , Cella David , Wagner Lynne I. 
Published: October 2015

BACKGROUNDPatients who receive adjuvant chemotherapy have reported cognitive impairments that may last for years after the completion of treatment. Working memory‐related and long‐term memory‐related changes in this population are not well understood. The objective of this study was to demonstrate that cancer‐related cognitive impairments are associated with the under recruitment of brain regions involved in working and recognition memory compared with controls.METHODSOncology patients (n = 15) who were receiving adjuvant chemotherapy and had evidence of cognitive impairment according to neuropsychological testing and self‐report and a group of age‐matched, education group‐matched, cognitively normal control participants (n = 14) underwent functional magnetic resonance imaging. During functional magnetic resonance imaging, participants performed a nonverbal n‐back working memory task and a visual recognition task.RESULTSOn the working memory task, when 1‐back and 2‐back data were averaged and contrasted with 0‐back data, significantly reduced activation was observed in the right dorsolateral prefrontal cortex for oncology patients versus controls. On the recognition task, oncology patients displayed decreased activity of the left‐middle hippocampus compared with controls. Neuroimaging results were not associated with patient‐reported cognition.CONCLUSIONSDecreased recruitment of brain regions associated with the encoding of working memory and recognition memory was observed in the oncology patients compared with the control group. These results suggest that there is a reduction in neural functioning postchemotherapy and corroborate patient‐reported cognitive difficulties after cancer treatment, although a direct association was not observed. Cancer 2016;122:258–268. © 2015 American Cancer Society.
FaceTime validation study: Low‐cost streaming video for cytology adequacy assessment
Authors: Agarwal Shweta , Zhao Lichao , Zhang Roy , Hassell Lewis 
Published: October 2015

BACKGROUNDAdequacy assessment for fine‐needle aspiration procedures is a standard of care in large medical centers. Although the benefits of this approach include higher adequacy rates with fewer passes, it costs cytopathologist time and affects other clinical responsibilities. The objective of the current study was to evaluate the use of mobile video streaming (FaceTime) technology with the help of smartphone adapters attached to microscopes for remote adequacy assessment of cytologic samples.METHODSThe study consisted of 2 phases: Phase 1 was a retrospective assessment of 25 samples by a primary pathologist with simultaneous streaming to a second pathologist using a smartphone (iPhone/iPad) FaceTime connection. Data on the adequacy of each sample and preliminary diagnoses were recorded. In phase 2, live cases were assessed prospectively by an onsite primary pathologist and by a remote pathologist using an iPhone/iPad‐FaceTime connection. The testing phase involved prospective assessment of additional samples with a resident or cytotechnologist as the slide driver.RESULTSIn phase 1, retrospective evaluation of 25 samples yielded considerable agreement (22 of 25 samples; 88%) between onsite and remote adequacy assessments. Three samples (12%) yielded results that did not agree, including 2 samples that were read as adequate in the onsite evaluation that were assessed as indeterminate using FaceTime. In phase 2 and in the testing phase, 14 samples exhibited considerable agreement on both adequacy and preliminary diagnosis (6 samples in phase 2 and 8 samples in the testing phase) and are currently available for reporting. Problems encountered include software version standardization, camera alignment, and (rarely) comprehension of the audio stream.CONCLUSIONSThe current data indicate that iPhone/iPad FaceTime technology can be used to perform remote adequacy assessments of fine‐needle aspirations and can help save valuable time for pathologists. Cancer Cytopathol 2016;124:213–220. © 2015 American Cancer Society.
Perspectives in Drug Development and Clinical Pharmacology: The Discovery of Histamine H1 and H2 Antagonists
Authors: Jones Alan Wayne 
Published: October 2015

AbstractKnowledge about the history and development of therapeutic agents holds a central position in the education and training of pharmacists and pharmacologists. Students enjoy learning about the discovery of drugs, including details about the pioneer workers involved (apothecaries, organic chemists, pharmacologists, and physiologists) and the role played by serendipity. The treatment of people suffering from allergies and the development of drugs that block the actions of histamine at H1 and H2 receptors are the subject of this review. Pharmaceutical products that block H1 receptors are widely used as prophylactic treatment for seasonal allergies that plague millions of people worldwide. The development of H2 receptor antagonists revolutionized treatment of gastric hyperacidity, the principal cause of peptic ulcers. Antihistamine research has changed focus toward the development of drugs that block the action of histamine at H3 and H4 receptors and the therapeutic potential is gradually being appreciated.
A Phase 1 Dose‐Escalation Study of ASP2409, a Selective T‐Cell Costimulation Inhibitor, in Stable Rheumatoid Arthritis Patients on Methotrexate Therapy
Authors: Zhang Wenhui , Kernstock Robert M. , Karrer Erik E. , Cohen Stanley B. , Chindalore Vishala L. , Kivitz Alan J. , Blahunka Paul C. , Delgado‐Herrera Leticia , Zeiher Bernhardt G. , Samberg Nancy L. , Garg Jay P. 
Published: October 2015

AbstractASP2409 represents a new class of CTLA4‐Ig molecules with higher binding avidity and selectivity to CD86. This first‐in‐human study was to assess the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics of ASP2409 in stable rheumatoid arthritis patients on methotrexate therapy with a randomized, double‐blind, placebo‐controlled dose‐escalation study design. Patients were enrolled and randomized in each of 8 dose‐escalation cohorts ranging from 0.001 to 3.0 mg/kg to receive either ASP2409 or placebo in a sequential manner. Escalation to higher dose levels occurred in the absence of dose‐limiting toxicity. A total of 57 patients completed the study. ASP2409 showed nonlinear PK over the dose range of 0.01 to 3.0 mg/kg following a single intravenous administration, indicating target‐mediated drug disposition. Area under the concentration–time curve (AUC) and maximum concentration (Cmax) increased at a greater than dose‐proportional rate. The half‐life of ASP2409 increased dose dependently and ranged from 1.57 to 6.68 days. ASP2409 showed a dose‐dependent increase in the extent and duration of CD86 receptor occupancy. There were no clinically relevant safety issues up to a single dose of 3.0 mg/kg. No maximum tolerated dose was reached. The incidence and duration of antidrug antibodies did not correlate with adverse events. ClinicalTrials.gov identifier: NCT02171143
Bio‐based Wrinkled Surfaces Harnessed from Biological Design Principles of Wood and Peroxidase Activity
Authors: Izawa Hironori , Okuda Noriko , Ifuku Shinsuke , Morimoto Minoru , Saimoto Hiroyuki , Rojas Orlando J. 
Published: October 2015

AbstractA new and simple approach for surface wrinkling inspired by polymer assemblies in wood fibers is introduced. A hard skin is synthesized on a linear polysaccharide support that resembles the structural units of the cell wall. This skin, a wood mimetic layer, is produced through immersion in a solution containing phenolic precursor and subsequent surface reaction by horseradish peroxidase. A patterned surface with micron‐scale wrinkles is formed upon drying and as a result of inhomogeneous shrinkage. We demonstrate that the design of the wrinkled surfaces can be controlled by the molecular structure of the phenolic precursor, temperature, and drying stress. It is noteworthy that this is a totally bio‐based system involving green materials and processes.
Seawater as Alternative to Freshwater in Pretreatment of Date Palm Residues for Bioethanol Production in Coastal and/or Arid Areas
Authors: Fang Chuanji , Thomsen Mette Hedegaard , Brudecki Grzegorz P. , Cybulska Iwona , Frankær Christian Grundahl , Bastidas‐Oyanedel Juan‐Rodrigo , Schmidt Jens Ejbye 
Published: October 2015

AbstractThe large water consumption (1.9–5.9 m3 water per m3 of biofuel) required by biomass processing plants has become an emerging concern, which is particularly critical in arid/semiarid regions. Seawater, as a widely available water source, could be an interesting option. This work was to study the technical feasibility of using seawater to replace freshwater in the pretreatment of date palm leaflets, a lignocellulosic biomass from arid regions, for bioethanol production. It was shown that leaflets pretreated with seawater exhibited lower cellulose crystallinity than those pretreated with freshwater. Pretreatment with seawater produced comparably digestible and fermentable solids to those obtained with freshwater. Moreover, no significant difference of inhibition to Saccharomyces cerevisiae was observed between liquids from pretreatment with seawater and freshwater. The results showed that seawater could be a promising alternative to freshwater for lignocellulose biorefineries in coastal and/or arid/semiarid areas.