bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prospective genetic germline evaluation in a consecutive group of adult patients aged <60 years with myelodysplastic syndromes
Authors: Attardi Enrico , Tiberi Lucia , Mattiuz Giorgio , Formicola Daniela , Dirupo Elia , Raddi Marco G. , Consagra Angela , Vergani Debora , Artuso Rosangela , Santini Valeria 
Published: July 2024

AbstractRelevance of germline (GL) predisposition in myelodysplastic syndromes (MDSs) was stressed in both 2022 WHO and International Consensus classifications, but its incidence is probably underestimated, especially in young adult patients. We selected a cohort of 31 consecutive de novo MDS patients with unusual young age (<60 years). We performed exome sequencing (ES) on DNA extracted from noninvasive sources (peripheral blood and saliva), filtering for a panel of 344 genes specifically tailored for detecting GL variants related to clonal and nonclonal cytopenia. We observed at least one high‐ or low‐confidence GL MDS variant in 7/31 (22.6%) and 9/31 (29.0%) of cases, respectively. Four of 31 patients (12.9%) confirmed having established MDS/AML predisposing disorders. We found heterozygous variants in genes involved in DNA repair/cancer predisposition (ATM, ATR, FANCM, PARN, BRCA1, BRCA2, CHEK2, MSH2) in 9/31 (29.0%) cases and variants affecting ribosome biogenesis (SBDS), hematopoietic stem cell (GATA2), and megakaryocyte (ANKRD26) differentiation in single cases. Two cases had variants in RBBP6, a gene previously described exclusively in familial myeloproliferative neoplasms. Lastly, four cases had variants in genes related to inherited anemias (CUBN and PIEZO1 genes). Our results showed that “young” MDS patients aged 40–60 years carried reported and unreported GL variants with an unexpectedly high proportion, and these events co‐occurred with somatic mutations recurrent in myeloid neoplasms. We explored the “no man's land” of the young adult MDS cases adopting a practical and scalable diagnostic tool, capable to detect GL variants avoiding invasive methods.
Monitoring of adaptive immune responses in healthcare workers who received a Coronavirus disease 2019 vaccine booster dose
Authors: Klinmalai Chompunuch , Srisala Supanart , Sahakijpicharn Thiantip , Apiwattanakul Nopporn 
Published: July 2024

AbstractBackground and AimsCoronavirus disease 2019 (COVID‐19) has become a global pandemic and led to increased mortality and morbidity. Vaccines against the etiologic agent; severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) were approved for emergency use on different platforms. In the early phase of the pandemic, Thai healthcare workers (HCWs) received CoronaVac, an inactivated vaccine, as the first vaccine against SARS‐CoV‐2, followed by ChAdOx1 nCoV‐19, a viral vector‐based vaccine, or BNT162b2, an mRNA vaccine, as a booster dose. This preliminary study evaluated the immunogenicity of ChAdOx1 nCoV‐19 and BNT162b2 as a booster dose in HCWs who previously received two doses of CoronaVac.MethodsTen HCW participants received ChAdOx1 nCoV‐19 and another 10 HCWs received BNT162b2 as a booster dose after two doses of CoronaVac. Anti‐RBD IgG, neutralizing antibodies (NAb), and cellular immunity, including interferon‐gamma (IFN‐γ)‐releasing CD4, CD8, double negative T cells, and NK cells, were measured at 3 and 5 months after the booster dose.ResultsThere was no significant difference in anti‐RBD IgG levels at 3 and 5 months between the two different types of booster vaccine. The levels of anti‐RBD IgG and NAb were significantly decreased at 5 months. HCWs receiving BNT162b2 had significantly higher NAb levels than those receiving ChAdOx1 nCoV‐19 at 5 months after the booster dose. IFN‐γ release from CD4 T cells was detected at 3 months with no significant difference between the two types of booster vaccines. However, IFN‐γ‐releasing CD4 T cells were present at 5 months in the ChAdOx1 nCoV‐19 group only.ConclusionChAdOx1 nCoV‐19 or BNT162b2 can be used as a booster dose after completion of the primary series primed by inactivated vaccine. Although the levels of immunity decline at 5 months, they may be adequate during the first 3 months after the booster dose.
JAMES BUTTLE REVIEW: Quantifying the influence of forestry and forest disturbance on stream temperature: Methodologies and challenges
Authors: Moore R. D. , MacDonald R. J. 
Published: July 2024

AbstractStream temperature governs many aquatic ecosystem processes and plays a key role in determining the distribution of cold‐water amphibians and cool‐ and cold‐water fish, including salmonids. Decades of research have focused on the effects of forestry and forest disturbance on stream temperature, and new projects are underway or being planned in jurisdictions including the Provinces of Alberta and British Columbia, Canada, and Washington State, USA. The objective of this paper is to provide a critical review of methodologies employed in previous studies. The review initially focuses on the range of metrics used to quantify stream thermal regimes and the factors that control stream temperature variability in time and space, then focuses on sampling and analytical methodologies used to quantify stream temperature response to forestry activity and forest disturbance. Empirical methods include sampling in time, space, or both, and may or may not include pre‐ and post‐harvest data. Process‐based mechanistic and hybrid empirical‐mechanistic models have also been applied. The advantages and disadvantages of these approaches are discussed, and recommendations provided to support the design and execution of future studies.
Two‐dimensional SnP2Se6 with gate‐tunable Seebeck coefficient for telecommunication band photothermoelectric detection
Authors: Zhu Bing‐Xuan , Zhu Cheng‐Yi , Qin Jing‐Kai , He Wen , Yue Lin‐Qing , Huang Pei‐Yu , Li Dong , Sun Ruo‐Yao , Ye Sheng , Du Yu , Sui Jie‐He , Li Ming‐Yu , Mao Jun , Zhen Liang , Xu Cheng‐Yan 
Published: July 2024

AbstractPhotothermoelectric (PTE) detectors combine photothermal and thermoelectric conversion, surmounting material band gap restrictions and limitations related to matching light wavelengths, have been widely used in telecommunication band detection. Two‐dimensional (2D) materials with gate‐tunable Seebeck coefficient can induce the generation of photothermal currents under illumination by the asymmetric Seebeck coefficient, making them promising candidate for PTE detectors in the telecommunication band. In this work, we report that a newly explored van der Waals (vdW) layered material, SnP2Se6, possessing excellent field regulation capabilities and behaviors as an ideal candidate for PTE detector implementation. With the assistance of temperature‐dependent Raman characterization, the suspended atomic thin SnP2Se6 nanosheets reveal thickness‐dependent thermal conductivity of 1.4–5.7 W m−1 K−1 at room temperature. The 2D SnP2Se6 demonstrates high Seebeck coefficient (S) and power factor (PF), which are estimated to be −506 μV K−1 and 207 μW m−1 K−2, respectively. By effectively modulating the SnP2Se6 localized carrier concentration, which in turn leads to inhomogeneous Seebeck coefficients, the designed dual‐gate PTE detector with 2D SnP2Se6 channel demonstrates wide spectral photoresponse in telecommunication bands, yielding high responsivity (R = 1.2 mA W−1) and detectivity (D* = 6 × 109 Jones) under 1550 nm light illumination. Our findings provide a new material platform and device configuration for the telecommunication band detection.image
Rewriting Sharon Tate's History in Once Upon A Time in … Hollywood
Authors: Rasmussen Douglas 
Published: July 2024

ABSTRACTAn examination of how director Quentin Tarantino rewrites the history of the Tate‐Labianca murders in the film Once Upon A Time in… Hollywood. By revising history and creating an alternate timeline where actress Sharon Tate is not murdered by Manson Family cultists, Tarantino is, in effect, also offering up a commentary on Hollywood itself. My essay will look at the artistic ramifications of these changes and how it affects viewer interpretations.
Dr. Manhattan's Penis: Traditions of Modesty and Morality in Alan Moore and Dave Gibbons's Watchmen
Authors: Williams G. Christopher 
Published: July 2024

ABSTRACTWatchmen expresses its internal debate about the understanding of good and evil through its frequent vacillation between images of both costume and nudity. Ultimately, nudity in the comic comes to represent a transcendence of the conventional morality most often represented in superhero comic books. Moore's and Gibbons's story of the shedding of clothing declares the notion that a traditional knowledge of good and evil may be inconvenient when trying to build a utopia.
Is Frank Miller's The Dark Knight Returns Fascist? Resolving the Paradoxes of Heroic Violence
Authors: Tkacz Carlos 
Published: July 2024

ABSTRACTThe Dark Knight Returns traces the polarizing paradoxes seen between the political left and right in the United States—the right at once advocating for distributed networks of self‐defense in widespread firearm availability and keeping the “thin blue line” of state power intact while the left simultaneously rejects both personal defense and policing as viable forms of mediation from bad actors—and then reimagines Batman as a metaphor by which these paradoxes are resolved.
This is the Legacy of Garry's Show: Restoring It's Garry Shandling's Show to the American Sitcom Canon
Authors: Hoffman Emily 
Published: July 2024

ABSTRACTThough largely forgotten, It's Garry Shandling's Show is a pivotal sitcom text that reclaims the self‐reflexive, meta‐narrative style of The George Burns and Gracie Allen Show. Shandling births the contemporary sitcom by de‐centering the idealized nuclear family; using Brechtian direct address that fuses the sitcom with stand‐up comedy; and parodying specific genres, films, and television shows. These destabilizing features turn the calcified genre into the television equivalent of Mikhail Bakhtin's carnival.
l‐2‐Hydroxyglutarate contributes to tumor radioresistance through regulating the hypoxia‐inducible factor‐1α signaling pathway
Authors: Zhang Manman , Liu Yingshuang , Lu Xinran , Du Liqing , He Ningning , Song Huijuan , Wang Jinhan , Gu Yeqing , Yang Mengmeng , Xu Chang , Wang Yan , Ji Kaihua , Liu Qiang 
Published: July 2024

Abstractl‐2‐Hydroxyglutarate (l‐2‐HG) has been regarded as a tumor metabolite, and it plays a crucial role in adaptation of tumor cells to hypoxic conditions. However, the role of l‐2‐HG in tumor radioresistance and the underlying mechanism have not yet been revealed. Here, we found that l‐2‐HG exhibited to have radioresistance effect on U87 human glioblastoma cells, which could reduce DNA damage and apoptosis caused by irradiation, promote cell proliferation and migration, and impair G2/M phase arrest. Mechanistically, l‐2‐HG upregulated the protein level of hypoxia‐inducible factor‐1α (HIF‐1α) and the expression levels of HIF‐1α downstream target genes. The knockdown of l‐2‐hydroxyglutarate dehydrogenase (L2HGDH) gene promoted the tumor growth and proliferation of U87 cells in nude mice by increasing HIF‐1α expression level in vivo. In addition, the low expression level of L2HGDH gene was correlated with the short survival of patients with glioma or kidney cancer. In conclusion, our study revealed the role and mechanism of l‐2‐HG in tumor radioresistance and may provide a new perspective for overcoming tumor radioresistance and broaden our comprehension of the role of metabolites in tumor microenvironment.
Population Pharmacokinetic Analysis of Dolutegravir in Treatment‐Experienced Adults Living with HIV‐1
Authors: Chandasana Hardik , Bush Mark , Ait‐Khaled Mounir , Wynne Brian , Min Sherene , Mehta Rashmi 
Published: July 2024

AbstractThe World Health Organization has recommended the use of dolutegravir (DTG) for both first and second‐line antiretroviral treatment in both adults and children down to 4 weeks of age. We developed a population pharmacokinetic(PopPK) model following oral administration of DTG 50 mg QD and 50 mg BID in HIV‐infected treatment‐experienced adults (607) based on pooled data from four phase 2/3 trials. DTG population pharmacokinetics are described by a one‐compartment model with first‐order absorption, absorption lag‐time, and first‐order elimination. The PopPK parameter estimates were apparent oral clearance (CL/F) = 1.00 L/h, apparent volume of distribution (V/F) = 18.9 L, absorption rate constant (Ka) = 1.99 per hour, and absorption lag time = 0.333 h, respectively. The final model included inter‐individual and inter‐occasion variability on apparent clearance (CL/F). Weight, smoking status, use of metabolic inducers as part of background antiretroviral therapy (ART) classified by their level of induction, use of atazanavir or atazanavir‐ritonavir as part of background ART, and albumin level were predictors of CL/F; weight and albumin level were predictors of V/F; and sex and concomitant use of metal cation‐containing vitamin/mineral supplements were predictors of relative bioavailability (F). The current model‐based analysis suggests that the DTG dose adjustment is not required based on the demographics, laboratory values, smoking status, concomitant use of mild metabolic inducers or inhibitors in the background therapy, or use of metal cation‐containing vitamin/mineral supplements because these covariate effects are not predicted to have a clinically relevant impact on safety and efficacy.
SARS‐CoV‐2 envelope protein‐derived extracellular vesicles act as potential media for viral spillover
Authors: Li Shuangqu , Bu Jiwen , Pan Xiaoyan , Li Qiguang , Zuo Xiaoli , Xiao Gengfu , Du Jiulin , Zhang Lei‐Ke , Xia Bingqing , Gao Zhaobing 
Published: July 2024

AbstractExtracellular vesicles (EVs) are shown to be a novel viral transmission model capable of increasing a virus's tropism. According to our earlier research, cells infected with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) or transfected with envelope protein plasmids generate a novel type of EVs that are micrometer‐sized and able to encase virus particles. Here, we showed the capacity of these EVs to invade various animals both in vitro and in vivo independent of the angiotensin‐converting enzyme 2 receptor. First, via macropinocytosis, intact EVs produced from Vero E6 (monkey) cells were able to enter cells from a variety of animals, including cats, dogs, bats, hamsters, and minks, and vice versa. Second, when given to zebrafish with cutaneous wounds, the EVs showed favorable stability in aqueous environments and entered the fish. Moreover, infection of wild‐type (WT) mice with heterogeneous EVs carrying SARS‐CoV‐2 particles led to a strong cytokine response and a notable amount of lung damage. Conversely, free viral particles did not infect WT mice. These results highlight the variety of processes behind viral transmission and cross‐species evolution by indicating that EVs may be possible vehicles for SARS‐CoV‐2 spillover and raising risk concerns over EVs' potential for viral gene transfer.
Connecting the Dots of Creativity and Curiosity: A Weekly Diary Examination Using Dynamic Structural Equation Modeling
Authors: Zampetakis Leonidas A. 
Published: July 2024

ABSTRACTIn the last decade, research on the connection between curiosity and creativity has surged revealing a positive correlation. However, these findings are primarily based on cross‐sectional studies, which do not establish the direction of the relationship between creativity and curiosity. Is curiosity the driving force behind creativity, or does creativity spark curiosity? The present study addresses this question by examining the potential reciprocal associations between creativity and curiosity within‐persons using state‐of‐the‐art methodology and statistics. Self‐reported data were collected on a weekly basis from a sample of Greek entrepreneurs (N = 195, 49% female) over a 10‐week period. We used the dynamic structural equation modeling (DSEM) framework for data analyses. Results supported the positive relationship between creativity and curiosity within and between individuals. At the within‐person level, creativity and curiosity exhibited significant carry‐over effects from 1 week to the next. However, we did not find consistent evidence for cross‐lagged effects, meaning that curiosity and creativity did not directly cause changes in each other within a 1‐week period. We also found significant random effects underscoring the role of curiosity as a catalyst for creativity, particularly when individuals do not have a strong tendency for their creative levels to persist but do have a strong tendency for their curiosity levels to persist. In such cases, curiosity seems to have a more pronounced impact on shaping creative endeavors. We discuss the implications of our findings for theory and practice and suggest directions for future research.
Ineffective esophageal motility: Characterization and outcomes across pediatric neurogastroenterology and motility centers in the United States
Authors: Davis Trevor A. , Rogers Benjamin D. , Llanos‐Chea Alejandro , Krasaelap Amornluck , Banks Darnna , Ambartsumyan Lusine , Sanchez Raul E. , Yacob Desale , Baker Corey , Rey Adriana Prada , Desai Chaitri , Rottier Aaron , Jayaraman Mayuri , Khorrami Camila , Dorfman Lev , El‐Chammas Khalil , Mansi Sherief , Chiou Eric , Chumpitazi Bruno P. , Balakrishnan Kesha , Puri Neetu B. , Rodriguez Leonel , Garza Jose M. , Saps Miguel , Gyawali Chandra Prakash , Patel Dhiren 
Published: July 2024

AbstractObjectivesIneffective esophageal motility (IEM) on high‐resolution manometry (HRM) is not consistently associated with specific clinical syndromes or outcomes. We evaluated the prevalence, clinical features, management, and outcomes of pediatric IEM patients across the United States.MethodsClinical and manometric characteristics of children undergoing esophageal HRM during 2021−2022 were collected from 12 pediatric motility centers. Clinical presentation, test results, management strategies, and outcomes were compared between children with IEM and normal HRM.ResultsOf 236 children (median age 15 years, 63.6% female, 79.2% Caucasian), 62 (23.6%) patients had IEM, and 174 (73.7%) patients had normal HRM, with similar demographics, medical history, clinical presentation, and median symptom duration. Reflux monitoring was performed more often for IEM patients (25.8% vs. 8.6%, p = 0.002), but other adjunctive testing was similar. Among 101 patients with follow‐up, symptomatic cohorts declined in both groups in relation to the initial presentation (p > 0.107 for each comparison) with management targeting symptoms, particularly acid suppression. Though prokinetics were used more often and behavioral therapy less often in IEM (p ≤ 0.015 for each comparison), symptom outcomes were similar between IEM and normal HRM. Despite a higher proportion with residual dysphagia on follow‐up in IEM (64.0% vs. 39.1%, p = 0.043), an alternate mechanism for dysphagia was identified more often in IEM (68.8%) compared to normal HRM (27.8%, p = 0.017).ConclusionsIEM is a descriptive manometric pattern rather than a clinical diagnosis requiring specific intervention in children. Management based on clinical presentation provides consistent symptom outcomes.
Thermally Stable and Transparent Polyimide Derived from Side‐Group‐Regulated Spirobifluorene Unit for Substrate Application
Authors: Fang Yunzhi , Lu Xuemin , Xiao Junjie , Zhang Shu‐Yu , Lu Qinghua 
Published: July 2024

AbstractAdvancements in flexible electronic technology, especially the progress in foldable displays and under‐display cameras (UDC), have created an urgent demand for high‐performance colorless polyimide (CPI). However, current CPIs lack sufficient heat resistance for substrate applications. In this work, four kinds of rigid spirobifluorene diamines are designed, and the corresponding polyimides are prepared by their condensation with 5,5′‐(perfluoropropane‐2,2‐diyl) bis(isobenzofuran‐1,3‐dione) (6FDA) or 9,9‐bis(3,4‐dicarboxyphenyl) fluorene dianhydride (BPAF). The rigid and conjugated spirobifluorene units endow the polyimides with higher glass transition temperature (Tg) ranging from 356 to 468 °C. Their optical properties are regulated by small side groups and spirobifluorene structure with a periodically twisted molecular conformation. Consequently, a series of CPIs with an average transmittance ranging from 75% to 88% and a yellowness index (YI) as low as 2.48 are obtained. Among these, 27SPFTFA‐BPAF presents excellent comprehensive performance, with a Tg of 422 °C, a 5 wt.% loss temperature (Td5) of 562 °C, a YI of 3.53, and a tensile strength (δmax) of 140 MPa, respectively. The mechanism underlying the structure‐property relationship is investigated by experimental comparison and theoretical calculation, and the proposed method provides a pathway for designing highly rigid conjugated CPIs with excellent thermal stability and transparency for photoelectric engineering.
Obesity‐associated factors in psychiatric outpatients: A multicenter questionnaire survey
Authors: Ishii Hiroki , Yamada Hiroki , Sato Ryotaro , Hayashi Wakaho , Nakamura Dan , Sugita Shutaro , Tazaki Taro , Takashio Osamu , Inamoto Atsuko , Iwanami Akira 
Published: July 2024

AbstractThe prevalence of obesity is increasing worldwide, resulting in various health issues such as hypertension, dyslipidemia, diabetes mellitus, heart disease, and a lower life expectancy. Importantly, several psychiatric disorders and the use of psychotropic medications have been linked to obesity, and the possible risk factors need further investigation. This study examined the prevalence of obesity and its associated factors using a self‐administered questionnaire. Participants were recruited from three outpatient clinics and individuals who met one or more of the ICD‐10 F0‐F9, G4 diagnoses were included. In total, 1384 participants completed the questionnaire about their lifestyle. Statistical analysis compared the demographic and clinical characteristics of the individuals who were obese (Body Mass Index: BMI ≥25) and those who were non‐obese (BMI <25). The results revealed that the factors associated with obesity in psychiatric outpatients were being male, prolonged treatment duration, eating out frequently, and use of both second‐ and first‐generation antipsychotics. The study emphasized the importance of closely monitoring BMI in individuals with multiple obesity‐related factors.
Trends of Rising Research Production Among Otolaryngology Residency Applicants
Authors: Smith Drew H. , Zeitouni Jad , Kim Thiesse Nayeon , Bowe Sarah N. 
Published: July 2024

AbstractAs competitiveness to obtain a residency position in the field of Otolaryngology–Head and Neck Surgery (Oto‐HNS) has continued to rise, applicants have endeavored to set themselves apart. One increasingly popular strategy is maximizing research output. Over the past 6 years, applicant metrics such as board scores and volunteer and work experiences have risen incrementally, while research production has more than doubled, from 8.4 mean number of abstracts, presentations, and publications in 2016 to 17.2 in 2022. This coincides with the exponential surge of new research fellowships among Oto‐HNS departments over a similar period, which is now up to at least 68 advertised positions. With a significant difference between the research production of matched and unmatched applicants, programs may be signaling a positive bias towards research‐heavy applicants. Whether this is intended and/or preferable should be examined more closely.