bluuebunny/crossref_metadata_2025_split huggingface dataset:
Basic aspects of ketamine therapy for treatment-resistant depression - a review paper
Authors: Szafrańska Weronika , Poborowska Dominika , Gańko Tomasz , Kahan Weronika , Bąk Emilia , Fordymacki Jacek , Wojaczek Marta , Polańska Katarzyna , Najjar Oliwia 
Published: July 2024

Introduction and purpose: Major depressive disorder (MDD) is the most common psychiatric illness, affecting millions of people worldwide. The first line of pharmacological treatment is usually monoamine reuptake inhibitors. Up to 60% of cases, may be drug-resistant patients, prompting researchers to research substances other than conventional. 1 The purpose of this article was to review recent studies on the use of ketamine in the treatment of drug-resistant depression and present their findings.

Brief description of the state of knowledge: Ketamine has been a well-known drug used in anesthesiology and pain management for decades. Because of its multidirectional effects, researchers have become interested in its effects on psychiatric illnesses. Over the past decade or so, there has been a definite increase in research and articles on the use of ketamine in psychiatry. The study has resulted in FDA approval of esketamine for the treatment of treatment-resistant depression in adults in 2019.

Material and method: This article is the result of searching keywords on databases such as Google Scholar and Pubmed and collecting scientific literature about depression and ketamine. Articles were preselected by title, number of citations, source, and publication date.

Summary: Ketamine has the potential to be a treatment for drug-resistant depression. Its effectiveness varies with the form and dosage, with racemic and higher doses offering greater therapeutic benefits. Ketamine's efficacy is on par with the electroconvulsive therapy. Its onset is faster than traditional antidepressants, significantly reducing suicide risk in a shorter time frame. While the precise mechanisms of its antidepressant effects are not fully understood, it is suggested that its impact on brain neuroplasticity may contribute to the rapid onset of action. Growing evidence supports ketamine's effectiveness in treating TRD, highlighting the need for further research in this area.
AILS-II: An Adaptive Iterated Local Search Heuristic for the Large-Scale Capacitated Vehicle Routing Problem
Authors: Máximo Vinícius R. , Cordeau Jean-François , Nascimento Mariá C. V. 
Published: July 2024

A recent study on the classical capacitated vehicle routing problem (CVRP) introduced an adaptive version of the widely used iterated local search paradigm, hybridized with a path-relinking (PR) strategy. The solution method, called adaptive iterated local search (AILS)-PR, outperformed existing meta-heuristics for the CVRP on benchmark instances. However, tests on large-scale instances suggest that PR is too slow, making AILS-PR less advantageous in this case. To overcome this challenge, this paper presents an AILS combined with mechanisms to handle large CVRP instances, called AILS-II. The computational cost of this implementation is reduced, whereas the algorithm also searches the solution space more efficiently. AILS-II is very competitive on smaller instances, outperforming the other methods from the literature with respect to the average gap to the best-known solutions. Moreover, AILS-II consistently outperforms the state of the art on larger instances with up to 30,000 vertices. History: Accepted by Ted Ralphs, Area Editor for Software Tools. This paper has been accepted for the INFORMS Journal on Computing Special Issue on Software Tools for Vehicle Routing. Funding: This work was supported by the Fundação de Amparo à Pesquisa do Estado de São Paulo [Grants 2013/07375-0, 2019/22067-6, and 2022/05803-3] and the Conselho Nacional de Desenvolvimento Científico e Tecnológico [Grants 309385/2021-0 and 403735/2021-1]. Supplemental Material: The software that supports the findings of this study is available within the paper and its Supplemental Information ( https://pubsonline.informs.org/doi/suppl/10.1287/ijoc.2023.0106 ) as well as from the IJOC GitHub software repository ( https://github.com/INFORMSJoC/2023.0106 ). The complete IJOC Software and Data Repository is available at https://informsjoc.github.io/ .
Reflections on How What We Say, Do, and Acknowledge as Intellectual and Developmental Disability Researchers Matters
Authors: Shogren Karrie A. 
Published: July 2024

Abstract
This article highlights reflections by the author on the importance of considering what we say, do and acknowledge in intellectual and developmental disability research. The goal is to advance thinking that can lead to personal and collective change in our approaches to truly share power and elevate the expertise of people with lived experience with intellectual and developmental disabilities in the movement for equity, inclusion, and disability justice. Implications for inclusive research, policy, and practice are discussed as is the need to engage in personal reflection and build new partnerships for collective change.
Screening to understand pregnancy preferences and offer referrals and treatment (SUPPORT): Results of a pilot quality improvement initiative
Authors: Janiak Elizabeth , Rexrode Kathryn , Santacroce Leah , Johns Sarah L. , Behn Maya , Braaten Kari P. , Feldman Candace H. 
Published: July 2024

Objective
To assess the feasibility of integrating a pregnancy intention assessment screening algorithm into the electronic medical record (EMR) at a multispecialty clinic focused on the health of women and people assigned female at birth (AFAB).

Study design
This pilot quality improvement project implemented a series of clinician reminders, new data fields in the patient record, and templated clinical notes to prompt care providers across specialties to ask AFAB reproductive age individuals about their desire for future pregnancies. Investigators created a novel screening question based on prior literature and expert input. Prospective observational study of one year of during-intervention EMR data on screening uptake and documentation, contraceptive use, and referrals to obstetrics and gynecology (OBGYN) for preconception care, contraceptive care, and related services.

Results
SUPPORT launched in February 2020 and was paused for 6 months due to the COVID-19 pandemic. During the intervention period through July 2021, 18% of patients for whom the automated screening reminder was activated had a documented pregnancy intention. Patients were screened in OBGYN, internal medicine, and eight subspecialty medical clinics. Among those screened, individuals who reported they did not desire pregnancy in the next year were more likely to use contraception (aOR 1.8, 95% CI 1.1, 3.1). Individuals that did desire pregnancy in the next year were more likely to be subsequently referred to OBGYN (aOR 2.7, 95% CI 1.2, 6.0).

Conclusions
Despite the competing demands of the COVID-19 pandemic, the SUPPORT intervention was utilized at higher rates than prior similar interventions and across multiple disease specialties.

Implications
Results from the SUPPORT pilot suggest that pregnancy intention screening of reproductive age AFAB individuals with an EMR-based screening prompt is feasible at scale.
Professionals’ experiences of what affects health outcomes in the sick leave and rehabilitation process—A qualitative study from primary care level
Authors: Löfgren Märit , Törnbom Karin , Gyllenhammar Daniel , Nordeman Lena , Rembeck Gun , Björkelund Cecilia , Svenningsson Irene , Hange Dominique 
Published: July 2024

Objective
To explore frontline employees’ experiences of how to create a purposeful sick leave and rehabilitation process (SRP) with the best interest of patients’ long-term health in focus.

Methods
Qualitative design based on focus group interviews in a primary care context in Region Västra Götaland, Sweden. Strategically selected professionals from different SRP organizations discussed sick leave outcomes and the rehabilitation process. Analysis was performed with Systematic text condensation.

Subjects
General practitioners (n = 6), rehabilitation coordinators and/or healthcare professionals from primary healthcare (n = 13), caseworkers from the Social Insurance Agency, the Employment Agency, and Social Services (n = 12).

Results
The outcome of the SRP was described to depend upon the extent to which the process meets patients’ bio-psycho-social needs. Aspects considered crucial were: 1) early bio-psycho-social assessments, including medical specialist consultations when needed, 2) long-term realistic planning of sick leave and rehabilitation alongside medical treatment, 3) access to a wide range of early rehabilitative and supportive interventions, including situation-based, non-medical practical problem solving, and 4) trusting relationships over time for all involved professions and roles to maximize process quality and person-centeredness. A gap between the desired scope of the SRP and existing guidelines was identified.

Conclusion
Interviewees perceived that successful outcomes from the sick leave and rehabilitation process in a primary care context depend on consensus, person-centeredness, and relationship continuity for all involved professions. An extended process scope and relationship continuity for all involved professionals were suggested to improve process outcomes.
Efficacy and Safety of Potassium-Competitive Acid Blockers vs Proton Pump Inhibitors for Peptic Ulcer Disease or Postprocedural Artificial Ulcers: A Systematic Review and Meta-analysis
Authors: Wang Wen-xin , Li Rui-jie , Li Xiong-fei 
Published: July 2024

INTRODUCTION:
Peptic ulcer disease (PUD) and postprocedural artificial ulcers are common ulcer disease. For them, proton pump inhibitor (PPI) and potassium-competitive acid blocker (P-CAB) are commonly used in clinical practice. PPI requires acid, time, and multiple doses, but P-CAB has fewer limitations. We compared the efficacy, safety, and prevention of PPI and P-CAB in PUD or artificial ulcer.

METHODS:
We searched PubMed, ClinicalTrials.gov, Embase, Cochrane Library, and Web of Science databases for all studies. All eligible randomized controlled trials up to August 5, 2023, were included. Healing rates, shrinking rates, treatment-emergent adverse events rates, and recurrence rates were measured. Risk of bias, sensitivity analyses, and heterogeneity were also performed.

RESULTS:
Twenty researches that were selected from 926 screening studies and in total 6,551 participants were included. The risk ratio (RR) of healing rate with P-CABs vs PPIs of PUD at 4 weeks was RR 1.01 (95% confidence interval 0.98–1.04). In addition, the healing rate distinction of artificial peptic ulcer was RR 1.04 (0.89–1.22), and the shrinking rate was mean difference 0.10 (−1.30–1.51). The result of treatment-emergent adverse event rate of PUD was RR 1.11 (0.91–1.35), and the delayed bleeding rate of artificial ulcer was RR 0.35 (0.16–0.80). The RR for recurrence rate of drug-related ulcers was 0.45 (0.25–0.81).

DISCUSSION:
P-CAB is noninferior in healing artificial ulcer and PUD, also the incidence of treatment-emergent adverse events. But, there may be a statistical advantage in holding back delayed bleeding and preventing drug-induced ulcers. More standardized experiments are needed for further applications and more precise conclusions.
Accurate non-ceruloplasmin bound copper: a new biomarker for the assessment and monitoring of Wilson disease patients using HPLC coupled to ICP-MS/MS
Authors: Harrington Chris F. , Carpenter Geoff , Coverdale James P.C. , Douglas Leisa , Mills Craig , Willis Karl , Schilsky Michael L. 
Published: July 2024

Abstract

Objectives
Assessment of Wilson disease is complicated, with neither ceruloplasmin, nor serum or urine copper, being reliable. Two new indices, accurate non-ceruloplasmin copper (ANCC) and relative ANCC were developed and applied to a cohort of 71 patients, as part of a Wilson Disease Registry Study.

Methods
Elemental copper-protein speciation was developed for holo-ceruloplasmin quantitation using strong anion exchange chromatography coupled to triple quadrupole inductively coupled plasma mass spectrometry. The serum proteins were separated using gradient elution and measured at m/z 63 (63Cu+) and 48 (32S16O+) using oxygen reaction mode and Cu-EDTA as calibration standard. The ANCC was calculated by subtraction of the ceruloplasmin bound copper from the total serum copper and the RelANCC was the percentage of total copper present as the ANCC.

Results
The accuracy of the holo-ceruloplasmin measurement was established using two certified reference materials, giving a mean recovery of 94.2 %. Regression analysis between the sum of the copper containing species and total copper concentration in the patient samples was acceptable (slope=0.964, intercept=0, r=0.987) and a difference plot, gave a mean difference for copper of 0.38 μmol/L. Intra-day precision for holo-ceruloplasmin at serum copper concentrations of 0.48 and 3.20 μmol/L were 5.2 and 5.6 % CV and the intermediate precision at concentrations of 0.80 and 5.99 μmol/L were 6.4 and 6.4 % CV, respectively. The limit of detection (LOD) and lower limit of quantification (LLOQ) for holo-ceruloplasmin were 0.08 and 0.27 μmol/L as copper, respectively.

Conclusions
ANCC and Relative ANCC are important new diagnostic and monitoring biomarker indices for Wilson disease (WD).
The role of constructions in understanding predictability measures and their correspondence to word duration
Authors: Bybee Joan , Brown Earl Kjar 
Published: July 2024

Abstract
Studies of word predictability in context show that words in English tend to be shorter if they are predictable from the next word, and to a lesser extent, if they are predictable from the previous word. Some studies distinguish function and content words, but otherwise have not considered grammatical factors, treating all two-word sequences as comparable. Because function words are highly frequent, words occurring with them have low predictability. Highest predictability occurs within bigrams with two content words. Using the Buckeye corpus, we show that content word bigrams from different constructions vary widely in predictability, with adjective–noun and noun–noun sequences (content words within a noun phrase) having the highest scores. It is known that in adjective–noun sequences, the vowel of the adjective is shorter than in other positions. We study noun–noun sequences within the noun phrase and show that the first noun is shorter than in other contexts. It follows that the shorter duration of the first word when it is predictable from the second in many cases is due to the noun phrase construction and not necessarily the regulation of duration corresponding to predictable versus unpredictable information. We conclude that predictability studies must consider the constructions words occur in.
Analysis of tumor detection using polydimethylsiloxane based wearable antenna
Authors: Angappan Karthikeyan T. , Nesasudha Moses , Zerith Moses Abi T. , Imoize Agbotiname Lucky 
Published: July 2024

Abstract
A Polydimethylsiloxane (PDMS) based antenna is designed for skin tumor detection. The antenna functions at 2.45 GHz with a bandwidth of 2.30–2.64 GHz working in the ISM (Industrial, Scientific, and Medical) band. The size of the antenna is 40 × 40 × 1 mm3. This antenna detects tumors in the skin by considering the variations in values of the E-field, J-surf, and H-field. Various analyses such as the distance between the patch and stacked layer skin phantom for different tumor sizes and input power to the antenna are changed and antenna performance is observed. A significant amount of changes is attained which denotes the presence of the tumor. The proposed antenna is fabricated and the corresponding results are analyzed in the Anechoic Chamber. The antenna has an efficiency of 99 % with a Specific Absorption Rate of 1.3846 W/kg which is lower than 1.6 W/kg as per the recommendations of FCC standard.
Evaluation of diagnostic potential of maternal serum ischemia modified albumin in cases of pre-eclampsia
Authors: Gupta Akshat , Jha Puja K. , Aggarwal Richa , Ahirwar Ashok K. , Almeida Edelbert A. , Kar Rajarshi 
Published: July 2024

Abstract

Objectives
The underlying causes and mechanisms of pre-eclampsia (PE), its exact etiology remains unclear and poorly understood. Hypoxia, ischemia, and oxidative stress induced by free radicals have been associated with development of PE. Ischemia-modified albumin (IMA) is a chemically modified albumin due to oxidative stress. IMA, a serum biomarker of hypoxia, ischemia, and oxidative free radicals is a potential biomarker for PE. The aim of the current proposal was to study serum IMA as a diagnostic biomarker of pre-eclampsia (PE) in pregnant females and to evaluate the correlation between serum IMA and different markers of pre-eclampsia (BP, urinary protein, LFT, KFT, serum total protein & uric acid).

Methods
A total of 60 pregnant women aged between 21 and 35 years were recruited (30 PE cases and 30 normal pregnancy). Serum IMA was measured by spectrophotometric method developed by Bar-Or D. BP and biochemical parameters (urinary protein, LFT, KFT, serum total protein & uric acid) were also assayed and compared between two groups. Correlation analysis was done for analyzing the relationship between serum IMA and biochemical parameters.

Results
The mean serum IMA was significantly higher in normotensive pregnant females (0.93 ABSU) than PE cases (0.71 ABSU). Kidney function and liver function parameters were more deranged in PE cases than in controls. Serum IMA was positively correlated with serum creatinine (r=0.322), serum uric acid (r=0.54) and urinary protein (0.376) whereas negatively correlated with total serum bilirubin (r=−0.515) and serum albumin (r=−0.380).

Conclusions
Elevated serum IMA concentrations in normotensive pregnant controls as compared to PE cases suggest that apart from ongoing ischemia and oxidative stress in placenta IMA values are influenced by many other mechanisms in pregnancy.
Rechtszynismus: Eine Untersuchung individueller und kontextueller Einflussfaktoren
Authors: Bertram Fee-Elisabeth , Häfele Joachim , Küchler Armin , Kurtenbach Sebastian 
Published: July 2024

Zusammenfassung
Rechtszynismus bezeichnet die Tendenz einer Person, geltende Gesetze nicht anzuerkennen oder für sich als nicht bindend zu empfinden. Ist der Rechtszynismus in einer Gesellschaft erhöht, stellt dies eine Bedrohung für die Funktionsweise eines Staates und die Demokratie dar. Um das Konzept Rechtszynismus zu verstehen und sein Ausmaß in der Bevölkerung beeinflussen zu können, ist es unerlässlich, individuelle und kontextuelle Faktoren zu identifizieren, die den Rechtszynismus begünstigen bzw. hemmen. Eine standardisierte Bevölkerungsbefragung (n = 1900) in 37 Dortmunder Stadtteilen zeigt u. a. eine hohe Selbstkontrolle als protektiven Faktor, während Diskriminierungserfahrungen sowie eine berichtete hohe Devianztoleranz von Peers als Risikofaktoren identifiziert werden konnten.
Cultural Preservation Through Immersive Technology: The Metaverse as a Pathway to the Past
Authors: Oladokun Bolaji David , Ajani Yusuf Ayodeji , Ukaegbu Bernadette C. N. , Oloniruha Emmanuel Adeniyi 
Published: July 2024

Abstract
This paper explores the potential of metaverse technology for the preservation of cultural heritage while acknowledging the obstacles that come with its implementation. It begins by highlighting the importance of safeguarding cultural heritage amidst the backdrop of globalization and technological advancements. The emergence of immersive technologies which include Virtual Reality, Augmented Reality and the Metaverse, is then introduced as a promising solution to address this challenge. The paper emphasises the transformative power of the metaverse in revitalising our interactions with digital content. Nevertheless, it also identifies various challenges associated with employing metaverse technology for cultural preservation. These challenges encompass technical limitations, ethical considerations regarding cultural representation and ownership, as well as concerns about privacy, data security, and digital rights management. Despite these hurdles, the research advocates for the utilization of immersive technology to protect and celebrate cultural heritage. It underscores the necessity for collaboration among stakeholders, such as technology developers, cultural institutions, communities, and policymakers, to tackle these challenges and ensure responsible and ethical preservation practices.
A complicit quest for silence
Authors: Puhr Björn 
Published: July 2024

Abstract
While this is not the first attempt at drawing a parallel between the philosophy of Ludwig Wittgenstein and the writings and musical experimentations of John Cage pertaining to silence, we try to further develop this fortunate example of synchronous investigations into the subject matter by pointing out the analogous transformations in their thought, leading from a silence that can be qualified as “mystical” or “spiritual” to an experience that confronts the listener with the very real contingency of their grammar itself, all the while basing ourselves on previous arguments and contributions. In the context of western classical music, we will show that by circumventing a conventional use of musical silence in which it is treated as an ordinary language-game, the authors discover an extramusical experience of silence that they will first explore by the means of spirituality before making the remarkable turn towards an understanding of silence as that which founds our every experience, be it at the cost of silence itself.
Seasonal Changes in Match Demands and Workload Distribution in Collegiate Soccer Across Two Seasons
Authors: Floersch Sean , Vidden Chad , Askow Andrew T. , Jones Margaret T. , Fields Jennifer B. , Jagim Andrew R. 
Published: July 2024

Abstract
Floersch, S, Vidden, C, Askow, AT, Jones, MT, Fields, JB, and Jagim, AR. Seasonal changes in match demands and workload distribution in collegiate soccer across two seasons. J Strength Cond Res 38(8): 1440–1446, 2024—The purpose of this study was to examine seasonal changes in match demands in a collegiate women's soccer team. Forty-eight NCAA Division III women soccer athletes (age: 19.5 ± 1.2 years; height: 1.67 ± 0.05 m; body mass: 64.8 ± 7.4 kg; fat-free mass: 50.0 ± 4.5 kg; body fat %: 22.6 ± 6.0) were equipped with wearable global positioning systems with inertial sensors and heart rate (HR) monitors during matches throughout the 2019 (n = 22) and 2021 seasons (n = 26). Players were classified by position: flank player (FP; n = 28), center midfielder (CM; n = 11), and center back fielder (CB; n = 9) and as starters (S, n = 17) or reserves (R, n = 31). Variables included HR, training load, total distance, high-speed distance, distance per minute, and weighted distance. Differences in match and practice session demands were analyzed using linear mixed-effects models with season (2 levels; 2019 and 2021) as a fixed factor, with alpha set to p = 0.05. Data across all matches and training sessions were collapsed and presented as mean ± SD for descriptive purposes and then grouped by session type (i.e., match or training) and position. Athletes traveled more distance at high speeds during match play in the 2021 season compared with 2019 (mean difference, 95% confidence intervals [CI]) (200, 95% CI: 104, 304 km; p < 0.05) but had a lower training load in 2021 compared with 2019 (−50, 95% CI: −63, −36; p < 0.05) during match play. For training sessions, mean HR (4, 95% CI: 2, 5 bpm), total distance (0.5, 95% CI: 0.4, 0.7), distance per minute (5.6, 95% CI: 4.5, 6.7 m·min−1), high-speed distance (43, 95% CI: 43, 18, 67 m), high accelerations (8.6, 95% CI: 5.4, 11.8 n), and high accelerations per minute (0.1, 95% CI: 0.1, 0.1 n·min−1) were all higher in 2021 compared with 2019 (p < 0.05). As a team, several differences in measures of external workload were found between seasons in both session types (training and matches). Variations in positional demands of match play appear to fluctuate by year.