bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organisation of the Work of Bioanalytical Laboratories according to the Principles of Good Clinical Laboratory Practice (Review)
Authors: Giba I. S. 
Published: August 2024

INTRODUCTION. Bioanalytical laboratories in the Russian Federation should follow the requirements of both the Good Laboratory Practices (GLP), when performing tests for non-clinical studies, and the Good Clinical Practices (GCP), when analysing samples from clinical studies. The work of such laboratories requires a separate GxP system, the Good Clinical Laboratory Practices (GCLP). However, the GCLP system has not yet been created in the Russian Federation and the Eurasian Economic Union (EAEU).АIM. This study aimed to compare the current Russian and EAEU principles regulating the work of bioanalytical laboratories with the international GCLP principles and formulate general requirements for national laboratories.DISCUSSION. The author analysed the current regulation of the work of bioanalytical laboratories, as well as the EAEU regulatory standards for the development and validation of analytical procedures. In addition, the study covered the international GCLP principles that govern the management of human resources, process record keeping, the development of standard operating procedures, the validation of analytical procedures, and the management of biological samples and reference standards in a laboratory. The author considered the key functions of a bioanalytical laboratory and suggested tools to manage them in compliance with the international GCLP principles and the EAEU requirements. It should be noted that scientific publications describe the international practice of applying the GCLP principles fairly well, and the experience of its implementation could be of use to Russian laboratories.CONCLUSION. A bioanalytical laboratory that implements the GCLP principles will increase its competitiveness in the EAEU market for bioanalytical testing services and mitigate its risks of obtaining invalid data.
Autonomy and Care: Bioethical Principles for Understanding Masculinities in Unemployed Men
Authors: Mendieta-Izquierdo Giovane , Cuevas-Silva Juan María 
Published: August 2024

Introduction: This study proposes an interdiscursive perspective between bioethics and the social and human sciences to understand the phenomenon of unemployment from the male perspective. The objective of the study is to analyse the bioethical principles of autonomy and care for the understanding of masculinity in unemployed men. Method: Qualitative case study from Yin's perspective with a hermeneutic approach, through in-depth interviews with a narrative biographical emphasis. Seven heterosexual men from Bogota, without employment and with family, were recruited through a combined purposive and convenience sampling process. Thematic analysis of the data was carried out after open coding of the narratives, which allowed the construction of families and emerging categories. Results: The main findings revolve around the principles of autonomy and care as macro categories of the social and human sciences and bioethics from a comprehensive perspective. Discussion: The analysis of the bioethical principles of autonomy and care provides key elements to build interdiscursive and interdisciplinary bridges between bioethics and the social and human sciences. It does this by addressing the social phenomenon of unemployment in men and its implications in the rupture of mental and contextual models of men that contribute to the understanding of masculinities.
Strategi Mempertahankan Usaha Franchise Pada Minuman Mixue di Indonesia
Authors: Najla Najla , Dewanthi Yani , Permana Erwin 
Published: August 2024

The franchise system provides various advantages for people who buy the system. By using a franchise system, it can provide benefits such as a business brand, logo, marketing, production methods, brand name, and a business system that has also been built from the start. One of the products that runs the franchise strategy to develop its business is the Mixue product. Even though it is relatively new, Mixue has experienced extraordinary development with quite high popularity. This study aims to analyze the strategy of maintaining a franchise business on Mixue drinks in Indonesia. The research was conducted with a qualitative approach. The collection technique uses searches on various official and popular sites as well as reviews of various official publications and scientific publications on the results of scientific research. The results of the study show that Mixue uses three strategies to maintain its business, namely producing contemporary products, low price strategy and FOMO strategy. With these three strategies, Mixue is competent enough to be able to maintain the franchise business. In Indonesia, they also have many outlets and can keep mixue popular among ice cream or boba drink products. Mixue is also able to compete with other companies that offer similar products at higher prices. The mixue outlet consistently applies the franchise concept as a mainstay for developing a business with very positive results. The researcher suggests Mixue business actors to develop new strategies in addition to maintaining existing strategies. The new strategy suggested is for example, business collaboration with complementary products that are well known in Indonesia, for example culinary shops that do not yet serve similar drinks, such as waroeng Special Sambal, solaria fried rice, etc. It is suggested to further researchers to conduct an analysis on the digital marketing aspects of Mixue products.
Nonlinear model of interaction of unsteady fluid flow with structure in hydraulic systems of aircraft and helicopters
Authors: Lukianov Pavlo , Pavlova Kateryna 
Published: August 2024

The subject of this work is the development of a nonlinear model of the interaction of an unsteady fluid flow with a structure and finding analytical solutions for the system of equations that correspond to the specified model. The convection effect of the fluid velocity field was already considered in the previous works of the authors of this paper. These studies are devoted to the water hammer without considering the "flow-structure" interaction. This work expands the possibilities of modeling and considers four equations instead of two equations of the theory of the water hammer (equations of conservation of mass and momentum), two of which relate to the motion of particles of a solid body (pipes or structures). The novelty of this work lies in the consideration of the model that describes the interaction of the flow with the structure, the convection in the velocity field, and the effect, together with the friction of the fluid against the solid wall, on the dynamics of the shock pulse propagation process both in the fluid and in the solid body. It should be noted that the solution of the nonlinear system of differential equations as a whole is carried out by an analytical method, which makes it possible to obtain an exact (rather than numerical) solution of the problem. Since the effects of various factors should be evaluated by comparison with the main components, dimensionless equations containing six parameters (dimensionless combinations) were obtained in this study. Two of these parameters were named after scientists – Darcy and Weisbach (steady friction) and Bruno (unsteady friction). Particular cases of the general (full) model were considered, and the effects of various factors on the dynamics of the interaction of the flow with the structure during the propagation of the shock pulse were determined. Research methods are purely theoretical. The concepts of a self-similar equation and a system of equations, balances of forces acting on particles of a fluid and a solid body, and a standard method of reducing a system of equations to a single equivalent equation are used. Conclusions. An extended model of the interaction between the unsteady fluid flow and the structure is proposed. The transition to a self-similar variable makes it possible to solve a nonlinear system of differential equations and obtain an analytical (exact) solution. The functions of longitudinal stress in a solid body, pressure disturbance, and velocity of motion of particles in a solid body (pipe) are linearly expressed by the velocity of shock pulse propagation in the fluid. It should also be noted that the results for the particular case of the linear model completely agree with the already known ones. The advantage of using a self-similar solution is that it is easy to obtain. The results of previous studies on the water hammer problem were qualitatively consistent. As the fluid viscosity increases, the shock pulse domain becomes more concentrative.
Implementasi Program Parenting Di Kelompok Bermain Cerdas Ceria Kota Serang
Authors: Windiyanti Titi , Fahmi Fahmi , Sayekti Tri 
Published: August 2024

This study aims to describe 1) parenting program implementation 2) benefits of parenting programs 3) supporting factors and inhibiting factors of parenting programs. The subjects of this study were principals, teachers and parents. Data collection using observation, interview and documentation techniques. The techniques used in data analysis are data reduction, data presen tation and conclusion drawing. Validity of data conducted to explain data using extended research, triangulation, membercheck and adequacy of references. The results showed that 1) The parenting program is carried out every three months with stages of planning, implementation and evaluation. Each theme is different, the first is about socializing school programs, the second is about maintaining the nutritional health of children and the third is about parenting in the digital era 2) this parenting program provides several benefits to respondents. 3) supporting factors include the enthusiasm of the participants, the solidarity of the committee, adequate facilities and infrastructure and the implementation time is not too long. Inhibiting factors include the lack of participants and the lack of school socialization.
Buku Saku Pintar sebagai Media Pengenalan Bahasa Isyarat untuk Meningkatkan Perbendaharaan Kata Siswa Tunarungu Jenjang SDLB
Authors: Subagja Muchamad Aditiya , Perdana Purnama Rika , Habudin Habudin , Isnaini Irma Azizatul 
Published: August 2024

Penelitian ini bertujuan untuk mengembangkan dan menghasilkan produk media Buku Saku Pintar untuk meningkatkan perbendaharaan kosakata siswa tunarungu serta mengetahui kelayakan dan efektifitasnya. Penelitian ini dilakukan di SKh Mathla’ul Anwar Menes jenjang SDLB dengan melibatkan 7 siswa tunarungu dan seorang guru. Metode yang digunakan pada penelitian ini adalah metode penelitian dan pengembangan atau research and development (R&D), menggunakan model ADDIE. Pada tahap analisis, pengumpulan data dilakukan melalui observasi dan wawancara. Tahap desain menghasilkan rancangan media Buku Saku Pintar. Tahap Pengembangan dilaksanakan melalui validasi kepada tiga validator. Tahap Implementasi dilakukan denggan memberikan soal pretest dan posttes kepada siswa tunarungu. Tahap Evaluasi menghasilkan penilaian setelah uji coba. Hasil penilaian kelayakan yang didapatkan dari validator ahli media sebesar 90% atau “Sangat Layak”, ahli materi sebesar 94% atau “Sangat Layak” dan ahli bahasa sebesar 100% atau “Sangat Layak”. Hasil uji coba produk kepada siswa tunarungu untuk mengetahui keefektifan media yang dikembangkan melalui pretest dan posttest mendapatkan skor n-gain 0,86 “Tinggi” dengan persentase 86% “Efektif”. Berdasarkan hasil penilaian tersebut, dapat disimpulkan bahwa media Buku Saku Pintar layak dan efektif untuk digunakan serta dapat meningkatkan perbendaaraan kosakata siswa tunarungu jenjang SDLB di SKh Mathla’ul Anwar Menes, Pandeglang-Banten.
Kata kunci: Bahasa Isyarat, Buku Saku Pintar, Media Pembelajaran, Siswa Tunarungu.
Problematika Pendidikan Kesetaraan Pada Masyarakat Desa Singkuang, Kecamatan Muara Batang Gadis, Kab.Mandailing Natal, Sumatera Utara
Authors: Safitri Adinda , Indria Nora Harahap Friska , Maritan Elisabet 
Published: August 2024

The lack of educational infrastructure and also low public awareness of education, due to economic factors, makes the dropout rate high. Due to the high dropout factor, the authors are interested in conducting research on equality education in Singkuang village, Mandailing Natal, North Sumatra. This study uses a descriptive qualitative approach. The data collection technique carried out in the village is by distributing online questionnaires to the people in Singkuang village. Based on research that has been carried out by observation and distributing google forms online, the authors found several factors causing equality education in Singkuang village, namely: The lack of educational facilities and infrastructure in Singkuang village and also the lack of knowledge and socialization about equality education to people who is in Singkuang village. Efforts made by the author to overcome the problem of equality education in Singkuang village are by conducting outreach to the Singkuang village community about the importance of equality education for those who drop out of school in order to get their education back and can help people find work in order to fulfill their life needs.
Geriatric assessment for the practicing clinician: The why, what, and how
Authors: Magnuson Allison , Loh Kah Poh , Stauffer Fiona , Dale William , Gilmore Nikesha , Kadambi Sindhuja , Klepin Heidi D. , Kyi Kaitlin , Lowenstein Lisa M. , Phillips Tanyanika , Ramsdale Erika , Schiaffino Melody K. , Simmons John F. , Williams Grant R. , Zittel Jason , Mohile Supriya 
Published: August 2024

AbstractOlder adults with cancer heterogeneously experience health care, treatment, and symptoms. Geriatric assessment (GA) offers a comprehensive evaluation of an older individual's health status and can predict cancer‐related outcomes in individuals with solid tumors and those with hematologic malignancies. In the last decade, randomized controlled trials have demonstrated the benefits of GA and GA management (GAM), which uses GA information to provide tailored intervention strategies to address GA impairments (e.g., implementing physical therapy for impaired physical function). Multiple phase 3 clinical trials in older adults with solid tumors and hematologic malignancies have demonstrated that GAM improves treatment completion, quality of life, communication, and advance care planning while reducing treatment‐related toxicity, falls, and polypharmacy. Nonetheless, implementation and uptake of GAM remain challenging. Various strategies have been proposed, including the use of GA screening tools, to identify patients most likely to benefit from GAM, the systematic engagement of the oncology workforce in the delivery of GAM, and the integration of technologies like telemedicine and mobile health to enhance the availability of GA and GAM interventions. Health inequities in minoritized groups persist, and systematic GA implementation has the potential to capture social determinants of health that are relevant to equitable care. Caregivers play an important role in cancer care and experience burden themselves. GA can guide dyadic supportive care interventions, ultimately helping both patients and caregivers achieve optimal health.
FORGE’d in FIRE III: The IMF in Quasar Accretion Disks from STARFORGE
Authors: Hopkins Philip F. , Grudic Michael Y. , Kremer Kyle , Offner Stella S. R. , Guszejnov David , Rosen Anna L. 
Published: August 2024

Recently, we demonstrated self-consistent formation of strongly-magnetized quasar accretion disks (QADs) from cosmological radiation-magnetohydrodynamic-thermochemical galaxy-star formation simulations, including the full STARFORGE physics shown previously to produce a reasonable IMF under typical ISM conditions. Here we study star formation and the stellar IMF in QADs, on scales from 100 au to 10 pc from the SMBH. We show it is critical to include physics often previously neglected, including magnetic fields, radiation, and (proto)stellar feedback. Closer to the SMBH, star formation is suppressed, but the (rare) stars that do form exhibit top-heavy IMFs. Stars can form only in special locations (e.g. magnetic field switches) in the outer QAD. Protostars accrete their natal cores rapidly but then dynamically decouple from the gas and ‘wander,’ ceasing accretion on timescales ~100 yr. Their jets control initial core accretion, but the ejecta are ‘swept up’ into the larger-scale QAD flow without much dynamical effect. The strong tidal environment strongly suppresses common-core multiplicity. The IMF shape depends sensitively on un-resolved dynamics of protostellar disks (PSDs), as the global dynamical times can become incredibly short (< yr) and tidal fields are incredibly strong, so whether PSDs can efficiently transport angular momentum or fragment catastrophically at <10 au scales requires novel PSD simulations to properly address. Most analytic IMF models and analogies with planet formation in PSDs fail qualitatively to explain the simulation IMFs, though we discuss a couple of viable models.
PENGARUH KEMAMPUAN PENALARAN MATEMATIS TERHADAP KEMAMPUAN PEMBUKTIAN MATEMATIS SISWA
Authors: Hendana Indah Putri , Lestari Karunia Eka 
Published: August 2024

Kemampuan pembuktian matematis merupakan suatu usaha yang dimiliki siswa dalam menunjukan kebenaran suatu pernyataan, baik untuk menyanggah atau mendukung. Usaha tersebut diperlukan kemampuan penalaran matematis, dimana siswa mampu untuk mengumpulkan dan menyimpulkan fakta-fakta. Penelitian ini merupakan penelitian kuantitatif dengan metode korelasional yang bertujuan untuk mengetahui pengaruh kemampuan penalaran matematis terhadap kemampuan pembuktian matematis. Hal ini dilihat dari hubungan linear dan besar pengaruh kemampuan penalaran matematis dalam menjelaskan variabilitas kemampuan pembuktian matematis. Penelitian ini dilakukan pada kelas VII dengan sampel sebanyak 68 siswa menggunakan pengambilan sampel cluster random sampling. Pengumpulan data menggunakan instrumen tes dan teknik analisis datanya dilakukan dengan regresi linear sederhana. Pada taraf kepercayaan 95%, cukup bukti untuk menunjukan dari hasil penelitian ini terdapat hubungan linier yang signifikan antara kemampuan penalaran matematis terhadap kemampuan pembuktian matematis siswa dengan pengaruh sebesar 25,6%.
Kepemimpinan Kepala Madrasah Dalam Meningkatkan Mutu Sumber Daya Guru
Authors: Nurlila Sintia , Nofrida Emiliya 
Published: August 2024

Peningkatan kualitas sumber daya manusia merupakan suatu keharusan bagi lembaga pendidikan, karena guru merupakan kunci utama keberhasilan proses belajar mengajar di sekolah. Kualitas siswa seringkali didukung oleh guru yang kompeten. Studi ini mengungkap kepemimpinan kepala madrasah dalam meningkatkan mutu sumber daya guru. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian ini adalah penelitian deskriptif analisis. Pengumpulan data dalam penelitian ini menggunakan teknik wawancara dan observasi. Data dianalisis dengan pendekatan Miles dan Huberman. Hasil penelitian menyebutkan bahwa kepemimpinan kepala madrasah dalam meningkatkan mutu sumber daya guru yaitu melakukan kegiatan pembinaan guru dalam bentuk mengikutsertakan guru dalam pelatihan atau seminar dan mendorong guru untuk melanjutkan pendidikan yang lebih tinggi.
PENGEMBANGAN BAHAN AJAR UNTUK MENUMBUHKAN KREATIFITAS BERWIRAUSAHA MAHASISWA DI FKIP
Authors: Andini Andini 
Published: August 2024

Pengembangan bahan ajar merupakan salah satu aspek pendorong dalam proses pembelajaran untuk dapat pembelajaran menjadi aktif. Pembelajaran kewirausahaan merupakan salah satu untuk menumbuhkan mahasiswa menjadi lebih kreatif dalam menciptakan hasil karya. Penelitian ini bertujan untuk mengetahui bagai mana pengembangan bahan ajar untuk menumbuhkan kreatifitas berwirauaha mahasiswa fkip. Metode penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif dengan melakukan wawancara untuk menggali informasi selama 4 hari. Subjek dari penelitian ini adalah Dosen dan Mahasiswa FKIP Unis. Hasil penelitian menjelaskan bahwa pengembangan bahan ajar berupa RPP atau silabus serta pedoman para ahli dan buku panduan untuk memotivasi mahasiswa dapat berkreatifitas dengan hasil karya yang mereka ciptakan.

Kata kunci: Pengembangan Bahan Ajar, Kreativitas, Kewirausahaan.
Pengembangan Materi Ajar Seni Tari Berbasis Kearifan Lokal Pada Siswa Sekolah Dasar
Authors: Ilham Ilham , Andang Andang , Ilyas Ilyas , Maisarah Maisarah , Reginasari Putri 
Published: August 2024

Modul kearifan lokal adalah untuk menunjang pembelajaran dan mengaitkan materi dengankeadaan lingkungan sekitar tempat tinggal dan sekolah. Tujuan dari penelitian mengetahui kevalidan, kepraktisan dan keefektifan. Penelitian ini menggunakan metode penelitian dan pengembangan ADDIE yang mengacu pada (Analysis, Design, Development, Implementation, and Evaluation). Teknik pengumpulan data dalam penelitian ini adalah ,wawancara, observasi, tes, valid, angket dan dokumentasi. Adapun teknik analisis data dalam penelitian ini meliputi analisis kevalidan kepraktisan dan keefektifan modul kearifan lokal .a) Hasil rekapitulasi kevalidtan modul kearifan lokal diperoleh 93% dengan kategori “Sangat Valid”. b) Hasil rekapitulasi kepraktisan modul kearifan lokal memperoleh persentase sebesar 77% dengan kategori “praktis”. c) Rekapitulasi hasil belajar kognitif siswa dengan nilai ketuntasan klasikal 19 orang siswa yang termasuk kategori “tuntas” dengan persentase 71’%, Tes hasil belajar afektif siswa,. orang siswa yang termasuk kategori baik dengan persentase 81%, Hasil belajar psikomotor diketahui hasil belajar psikomotor terdapat 19 orang siswa termaksud kategori “baik” dengan presentase 79%. Pengembangan modul kearifan lokal yang inovasi dapat mempermudah siswa dalam proses, pembelajaran, sehingga tujuan pembelajaran tercapai dan dapat meningkatkan hasil belajar siswa SD Negeri 27 woja Tahun Pembelajaran 2023/2024.
Sistem Informasi Pengajuan Izin Usaha Dinas Pertanian dan Pangan Banyuwangi
Authors: Indah Indah 
Published: August 2024

izin usaha menjadi salah satu hal yang penting untuk menjamin kualitas produk yang dihasilkan sehingga konsumen mendapatkan jaminan kualitas mutu yang baik sebagai Salah satu upaya untuk menjaga ketahanan pangan masyarakat adalah dengan adanya. Diera persaingan ketat antar perusahaan karena perkembangan teknologi yang membuka luasnya peluang pasar global menuntut palaku usaha berinovasi dalam mengembangkan usahanya sehingga tidak jarang oknum pelaku usaha melakukan hal yang dapat mengurangi mutu bara yang diproduksi.Dinas pertanian dan pangan berperan menjalanka tugas pemerintahan yang membawahi ketahanan pangan. Perannya dalam menjaga ketahan pangan adalah dengan adanya pelayanan izin usaha utamanya dibidang kesehatan hewan dan kesehatan masyarakat veteriner. Dalam proses pengajuan izin usaha memerlukan beberapa berkas yang perlu dilengkapi oleh pengusaha yang ingin mengajukan izin usaha. Termasuk form pengajuan izin yang berisi data diri pengusaha dan usaha yang diajukan. Namun terkadang bebrapa hal mengenai akurasi data dengan adanya beberapa kendala mulai dari proses pegantaran berkas, sampai pada pengisian form pengajuan manual kurang efektif.Berdasarkan latar belakang yang dipaparkan diatas dapat disimpulkan bahwa permasalahan yang dihadapi adalah bagaimana merancang sistem informasi yang dapat membantu dan mengefisienkan proses pengajuan izin usaha. Maka penelitian ini menghasilkan “aplikasi pengajuan izin usaha dinas pertanian dan pangan banyuwangi” berbasis web yang efisien dan akurat