bluuebunny/crossref_metadata_2025_split huggingface dataset:
Les souvenirs laissés par les bons enseignants d'EPS : l'assertivité socio-conative comme concept explicatif
Authors: Meyre Jean-Michel 
Published: July 2013

Cet article tente d’expliquer que la cause déterminante dans l’appréciation des enseignants d’EPS repose sur leur capacité à avoir de l’assertivité socio-conative. L’enquête a été menée à la fois par questionnaires, mais également par entretiens semi-directifs. L’analyse relève quatre invariants spécifiques aux enseignants d’EPS jugés « bons » par leurs anciens élèves. Ces éléments, propres à toute relation humaine harmonieuse, sont regroupés sous le concept d’assertivité socio-conative, qui rassemble au moins deux qualités, la première étant l’empathie, et la seconde l’affirmation de soi. Cette capacité, liée aux valeurs intégrées, détenue et mise en œuvre au cours de toute relation avec autrui, conditionne la relation enseignant-enseigné et par voie de conséquence le jugement de valeur qui en résulte.
El Dr. Enrique Romero Brest, las visitas a instituciones europeas de formación y el Congreso de Educación Física realizado en 1913 como indicadores de la globalización y la nacionalización de la « cultura física »
Authors: Pablo Scharagrodsky , Gleyse Jacques 
Published: July 2013

Enrique Romero Brest est considéré comme le fondateur de la méthode argentine d’Éducation physique et, pour partie, le créateur du champ de l’Éducation physique dans ce pays au tournant du XX e siècle. Il est l’un des acteurs qui contribuera au processus de mondialisation de ce champ de connaissance, notamment en réalisant plusieurs voyages en Europe et en s’inspirant et en s’appropriant d’autres méthodes d’Éducation physique. Cependant, il réorganisera également ces méthodes pour tenter d’en dégager une méthode spécifique à l’Argentine en particulier. Les archives étudiées sont les actes de différents congrès européens d’Éducation physique entre 1900 et 1913 et spécifiquement ces dernières ainsi que l’ensemble des archives concernant Romero Brest dans les fonds argentins (Buenos Aires, La Plata). L’article montre comment s’est organisée la participation d’Enrique Romero Brest aux différents congrès européens mais aussi ce qu’il a pu en retirer pour constituer une méthode argentine d’Éducation physique. Il démontre aussi à la fois la construction d’une identité nationale sur le sujet et un processus de colonisation théorique ou plus largement de mondialisation de la connaissance dans le domaine.
The Composite Cytokine p28/Cytokine-Like Factor 1 Sustains B Cell Proliferation and Promotes Plasma Cell Differentiation
Authors: Tormo Aurélie Jeanne , Meliani Yasmine , Beaupré Linda Ann , Sharma Mukut , Fritz Jörg H. , Elson Greg , Crabé Sandrine , Gauchat Jean-François 
Published: July 2013

Abstract
IL-27 is an APC-derived IL-6/IL-12 family composite cytokine with multiple functions such as regulation of Th1, Th17, and regulatory T cell differentiation, B cell proliferation, and Ig class switching. The IL-27 complex is formed by the association of the cytokine p28 with the soluble cytokine receptor EBV-induced gene 3 (EBI3). The IL-27 cytokine and soluble receptor subunits p28 and EBI3 can be secreted independently. The p28 subunit has been shown to have IL-27–independent biological activities. We previously demonstrated that p28 can form an alternative composite cytokine with the EBI3 homolog cytokine-like factor 1 (CLF; CRLF1). p28/CLF modulates NK cell activity and CD4 T cell cytokine production in vitro. In this study we used IL-6–dependent plasmacytoma cell line B9 and CD4 T cells from IL-27Rα–deficient mice to demonstrate that p28/CLF activates IL-27–unresponsive cells, indicating that p28/CLF and IL-27 signal through different receptors. The observation that p28/CLF, unlike IL-27, sustains B9 plasmacytoma cell proliferation prompted us to investigate the effects of p28/CLF on mouse B cells. We observed that p28/CLF induces IgM, IgG2c, and IgG1 production and plasma cell differentiation. p28/CLF therefore has the potential to contribute to B and plasma cell function, differentiation, and proliferation in normal and pathological conditions such as Castelman’s disease and multiple myeloma.
Phenotypic CD8+ T Cell Diversification Occurs before, during, and after the First T Cell Division
Authors: Lemaître Fabrice , Moreau Hélène D. , Vedele Laura , Bousso Philippe 
Published: July 2013

Abstract
Effector T cell responses rely on a phenotypically and functionally heterogeneous population of cells. Whether this diversity is programmed before clonal expansion or in later phases as a result of stochastic events or asymmetric cell division is not fully understood. In this study, we first took advantage of a sensitive in vitro assay to analyze the composition of single CD8+ T cell progenies. Heterogeneity was predominantly observed between progenies of distinct clones, but could also be detected within individual progenies. Furthermore, by physically isolating daughter cells of the first T cell division, we showed that differences in paired daughter cell progenies contributed to intraclonal diversification. Finally, we developed an in vivo limiting dilution assay to compare individual T cell progenies following immunization. We provided evidence for simultaneous intraclonal and interclonal diversification in vivo. Our results support the idea that T cell diversification is a continuous process, initiated before clonal expansion and amplified during the first and subsequent cell divisions.
A noncommutative sigma model
Authors: Van den Worm Mauritz 
Published: July 2013

We replace the classical string theory notions of mapping between parameter space and world-time with noncommutative tori mapping between these spaces. The dynamics of mappings between different noncommutative tori are studied and noncommutative versions of the Polyakov action and the Euler-Lagrange equations are derived. The quantum torus is studied in detail, as well as C*-homomorphisms between different quantum tori. A finite dimensional representation of the quantum torus is studied, and the partition function and other path integrals are calculated. At the end we prove existence theorems for mappings between different noncommutative tori.
A Multicenter, Retrospective Study of Patients with Pulmonary Arterial Hypertension Transitioned from Parenteral Prostacyclin Therapy to Inhaled Iloprost
Authors: Channick Richard N. , Frantz Robert P. , Kawut Steven M. , Palevsky Harold , Tumuluri Ramagopal , Sulica Roxana , Lauto Paula O. , Benton Wade W. , de Boisblanc Bennett 
Published: July 2013

Pulmonary arterial hypertension (PAH) is characterized by progressive increases in pulmonary vascular resistance, leading to right heart failure and death. Guidelines recommend customization of treatment, necessitating the development of effective strategies for transitioning patients among treatments. In this study, we characterized our experience with patient transitions from parenteral prostacyclin to inhaled iloprost. We retrospectively assessed records from 11 centers of 37 consecutive patients with PAH aged ≥ 18 years who were treated with intravenous (IV) or subcutaneous (SC) prostacyclin analogues and transitioned to inhaled iloprost. The transition period began on the first day of inhaled iloprost with the intent of discontinuing parenteral prostacyclin and ended on the first day on inhaled iloprost free of parenteral prostacyclin. Persistence was defined as the absence of (1) parenteral prostacyclin while remaining on inhaled iloprost during post‐transition Days 1–90 and (2) no reinitiation of parenteral prostacyclin during post‐transition Days 90–365. All patients were clinically stable before transitioning to inhaled iloprost. The mean age was 46.5 years, 70.3% were female, 51.4% had idiopathic PAH, and 43.0% were in New York Heart Association Functional Class III. Among patients with an overlapping transition, the mean transition period was 10.5 days. A transition dosing algorithm was used in 10 patients (27.0%). At one year, 78.4% of the patients remained persistent on inhaled iloprost and 81.1% were free of clinical worsening. In selected patients on background oral PAH therapy, transitioning from parenteral prostacyclin to inhaled iloprost appears safe and feasible and is associated with long‐term success. Further study is needed to define the optimal patient selection criteria and transition algorithm.
Optimization of Isolated Perfused/Ventilated Mouse Lung to Study Hypoxic Pulmonary Vasoconstriction
Authors: Yoo Hae Young , Zeifman Amy , Ko Eun A. , Smith Kimberly A. , Chen Jiwang , Machado Roberto F. , Zhao You‐Yang , Minshall Richard D. , Yuan Jason X.‐J. 
Published: July 2013

Hypoxic pulmonary vasoconstriction (HPV) is a compensatory physiological mechanism in the lung that optimizes the matching of ventilation to perfusion and thereby maximizes gas exchange. Historically, HPV has been primarily studied in isolated perfused/ventilated lungs; however, the results of these studies have varied greatly due to different experimental conditions and species. Therefore, in the present study, we utilized the mouse isolated perfused/ventilated lung model for investigation of the role of extracellular Ca2+ and caveolin‐1 and endothelial nitric oxide synthase expression on HPV. We also compared HPV using different perfusate solutions: Physiological salt solution (PSS) with albumin, Ficoll, rat blood, fetal bovine serum (FBS), or Dulbecco's Modified Eagle Medium (DMEM). After stabilization of the pulmonary arterial pressure (PAP), hypoxic (1% O2) and normoxic (21% O2) gases were applied via a ventilator in five‐minute intervals to measure HPV. The addition of albumin or Ficoll with PSS did not induce persistent and strong HPV with or without a pretone agent. DMEM with the inclusion of FBS in the perfusate induced strong HPV in the first hypoxic challenge, but the HPV was neither persistent nor repetitive. PSS with rat blood only induced a small increase in HPV amplitude. Persistent and repetitive HPV occurred with PSS with 20% FBS as perfusate. HPV was significantly decreased by the removal of extracellular Ca2+ along with addition of 1 mM EGTA to chelate residual Ca2+ and voltage‐dependent Ca2+ channel blocker (nifedipine 1 μM). PAP was also reactive to contractile stimulation by high K+ depolarization and U46619 (a stable analogue of thromboxane A2). In summary, optimal conditions for measuring HPV were established in the isolated perfused/ventilated mouse lung. Using this method, we further confirmed that HPV is dependent on Ca2+ influx.
Overcoming Challenges to Initiating Cell Therapy Clinical Trials in Rapidly Developing Countries: India as a Model
Authors: Viswanathan Sowmya , Rao Mahendra , Keating Armand , Srivastava Alok 
Published: July 2013

Abstract
Increasingly, a number of rapidly developing countries, including India, China, Brazil, and others, are becoming global hot spots for the development of regenerative medicine applications, including stem cell-based therapies. Identifying and overcoming regulatory and translational research challenges and promoting scientific and ethical clinical trials with cells will help curb the growth of stem cell tourism for unproven therapies. It will also enable academic investigators, local regulators, and national and international biotechnology and biopharmaceutical companies to accelerate stem cell-based clinical research that could lead to effective innovative treatments in these regions. Using India as a model system and obtaining input from regulators, clinicians, academics, and industry representatives across the stem cell field in India, we reviewed the role of key agencies and processes involved in this field. We have identified areas that need attention and here provide solutions from other established and functioning models in the world to streamline and unify the regulatory and ethics approval processes for cell-based therapies. We also make recommendations to check the growth and functioning of clinics offering unproven treatments. Addressing these issues will remove considerable hurdles to both local and international investigators, accelerate the pace of research and development, and create a quality environment for reliable products to emerge. By doing so, these countries would have taken one important step to move to the forefront of stem cell-based therapeutics.
Les "modernes" religioses valencianes: entrebancs d'una recerca textual
Authors: Herrero Herrero Maria Ángeles 
Published: July 2013

Resum: El catàleg titulat Lletraferides modernes. Catàleg de les escriptores valencianes dels segles XVI-XVIII (Herrero 2009) suposava un punt de partida en la compilació de «lletraferides» valencianes de l’Edat Moderna. Aquest ajudà a rescatar els seus noms, però el major handicap radica en la diversitat en la localització física dels textos. A través d’una visió dels diferents gèneres que empraren aquestes escriptores, en especial les religioses (poesia, mística, auto/biografia espiritual…), avancem algunes conclusions que permetran una anàlisi sociolingu?ística, literària i de gènere d’eixes obres.Paraules clau: Catàleg, Localizació textual, Autores religioses, Valencianes, Modernes.Abstract: The catalogue entitled Lletraferides modernes. Catàleg de les escriptores valencianes dels segles XVI-XVIII (Herrero 2009) provided a starting point for the compilation of Valencian «women of letters» in the Modern Age. Although this catalogue helped to recover the names of these authors, the process is greatly hindered by the diversity of textual localisation. By considering the different genres these writers, particularly the religious authors, favoured (poetry, mystic, spiritual auto/biography,…), this paper aims to provide a number of conclusions for subsequent application in the sociolinguistic, literary and genre analysis of these works.Keywords: Catalogue, Textual localisation, Women religious authors, Valencian, Modern
Silencing women’s sexuality: global AIDS policies and the case of the female condom
Authors: Peters Anny JTP , van Driel Francien TM , Jansen Willy HM 
Published: July 2013

IntroductionThe female condom is the only evidence‐based AIDS prevention technology that has been designed for the female body; yet, most women do not have access to it. This is remarkable since women constitute the majority of all HIV‐positive people living in sub‐Saharan Africa, and gender inequality is seen as a driving force of the AIDS epidemic. In this study, we analyze how major actors in the AIDS prevention field frame the AIDS problem, in particular the female condom in comparison to other prevention technologies, in their discourse and policy formulations. Our aim is to gain insight into the discursive power mechanisms that underlie the thinking about AIDS prevention and women’s sexual agency.MethodsWe analyze the AIDS policies of 16 agencies that constitute the most influential actors in the global response to AIDS. Our study unravels the discursive power of these global AIDS policy actors, when promoting and making choices between AIDS prevention technologies. We conducted both a quantitative and qualitative analysis of how the global AIDS epidemic is being addressed by them, in framing the AIDS problem, labelling of different categories of people for targeting AIDS prevention programmes and in gender marking of AIDS prevention technologies.ResultsWe found that global AIDS policy actors frame the AIDS problem predominantly in the context of gender and reproductive health, rather than that of sexuality and sexual rights. Men’s sexual agency is treated differently from women’s sexual agency. An example of such differentiation and of gender marking is shown by contrasting the framing and labelling of male circumcision as an intervention aimed at the prevention of HIV with that of the female condom.ConclusionsThe gender‐stereotyped global AIDS policy discourse negates women’s agency in sexuality and their sexual rights. This could be an important factor in limiting the scale‐up of female condom programmes and hampering universal access to female condoms.
A Review of Reagents for Fluorescence Microscopy of Cellular Compartments and Structures, Part I: BacMam Labeling and Reagents for Vesicular Structures
Authors: Dolman Nick J. , Kilgore Jason A. , Davidson Michael W. 
Published: July 2013

AbstractFluorescent labeling of vesicular structures in cultured cells, particularly for live cells, can be challenging for a number of reasons. The first challenge is to identify a reagent that will be specific enough where some structures have a number of potential reagents and others very few options. The emergence of BacMam constructs has allowed more easy‐to‐use choices. Presented here is a discussion of BacMam constructs as well as a review of commercially‐available reagents for labeling vesicular structures in cells, including endosomes, peroxisomes, lysosomes, and autophagosomes, complete with a featured reagent for each structure, recommended protocol, troubleshooting guide, and example image. Curr. Protoc. Cytom. 65:12.30.1‐12.30.27. © 2013 by John Wiley & Sons, Inc.
Usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study
Authors: Ebbo Mikael , Grados Aurélie , Guedj Eric , Gobert Delphine , Colavolpe Cécile , Zaidan Mohamad , Masseau Agathe , Bernard Fanny , Berthelot Jean‐Marie , Morel Nathalie , Lifermann François , Palat Sylvain , Haroche Julien , Mariette Xavier , Godeau Bertrand , Bernit Emmanuelle , Costedoat‐Chalumeau Nathalie , Papo Thomas , Hamidou Mohamed , Harlé Jean‐Robert , Schleinitz Nicolas 
Published: July 2013

ObjectiveTo evaluate the usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–positron emission tomography/computed tomography (FDG‐PET/CT) in IgG4‐related disease (IgG4‐RD) for the staging of the disease and the followup under treatment.MethodsAll patients included in the French IgG4‐RD registry who underwent ≥1 FDG‐PET/CT scan were included in the study. Clinical, biologic, pathologic, radiologic, and FDG‐PET/CT qualitative and quantitative findings were retrospectively collected and analyzed.ResultsTwenty‐one patients were included in the study and 46 FDG‐PET/CT examinations were evaluated. At either diagnosis or relapse, all evaluated patients presented abnormal 18F‐FDG uptake in typical IgG4‐RD localizations. In most cases, FDG‐PET/CT was more sensitive than conventional imaging to detect organ involvement, especially in arteries, salivary glands, and lymph nodes. In few cases (small‐sized lesions and brain or kidney contiguous lesions), false‐negative results were noted. Evaluation before and after treatment showed in most cases a good correlation of FDG‐PET/CT results with treatment response and disease activity.ConclusionThis large retrospective study shows that FDG‐PET/CT imaging is useful for the staging of IgG4‐RD. Moreover, FDG‐PET/CT is useful to assess the response to treatment during followup.
Functionally Optimized Orthoses for Early Rheumatoid Arthritis Foot Disease: A Study of Mechanisms and Patient Experience
Authors: Gibson Kellie S. , Woodburn James , Porter Duncan , Telfer Scott 
Published: July 2013

ObjectiveTo investigate the mode‐of‐action and patient experience of functionally optimized foot orthoses in patients with early rheumatoid arthritis (RA).MethodsWe conducted an investigation of 2 functionally optimized foot orthoses (selective laser sintering [SLS] and fused deposition modelling [FDM]) in 15 patients with RA of <2 years duration. The novel devices were optimized for 3 biomechanistic targets exploiting computer‐aided design and additive manufacturing. A third standard device was used as the comparator (standard foot orthosis [SFO]). Foot and ankle biomechanical effects were compared. Adverse reactions, orthotic fit and comfort, and short‐term symptom benefits were also monitored.ResultsBoth FDM (P = 0.028) and SLS (P < 0.0001) orthoses significantly reduced peak rearfoot motion in comparison to shod. The average ankle internal moment was significantly decreased in the SFO (P = 0.010) and approached significance in the SLS (P = 0.052) orthosis. SFO, FDM, and SLS orthoses significantly increased the peak height of the medial foot arch between 3.6 to 4.4 mm (P < 0.001). Peak pressures in the medial (P = 0.018) and lateral forefoot (P = 0.022) regions of interest were significantly reduced for the SLS orthosis. SFO, FDM, and SLS orthoses significantly increased midfoot contact area (P < 0.001 for all conditions). In comparison to SFO, SLS and FDM orthoses provided equivalent or better patient experience. No adverse reactions were reported.ConclusionFunctional optimization is a feasible approach for orthoses prescription in early RA and has the potential to provide superior mode‐of‐action responses for biomechanical therapeutic targets compared to standard devices.
Co‐creation of Value by Open Innovation: Unlocking New Sources of Competitive Advantage
Authors: Martinez Marian Garcia 
Published: July 2013

ABSTRACTA focus on the consumer has been recognized as the key to unlocking new sources of competitive advantage. This paper looks at this new perspective in value creation where personalized consumer experience takes central stage as opposed to a product and firm‐centric view. Through an explorative case study, the paper illustrates how a joint innovation effort between Molson Coors Brewing Company UK (MCBC‐UK) and a supplier is leading to more open approaches as consumers are involved in the process. By understanding what consumers' value and engaging in active dialog and interaction, MCBC‐UK has been able to develop superior value propositions relevant to their target consumer base. The case underscores the role of consumer value creation in a commoditizing world where companies can seek to maximize the lifetime value of desirable consumer segments by taking consumers as a partner or co‐producer instead of an external element. Food and drink companies have the opportunity to add value and extricate themselves from commodity sectors where the lowest cost provider holds sway by embracing consumers' ideas as part of the innovation process.
Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation
Authors: Kremer David , Schichel Tanja , Förster Moritz , Tzekova Nevena , Bernard Corinne , van der Valk Paul , van Horssen Jack , Hartung Hans‐Peter , Perron Hervé , Küry Patrick 
Published: July 2013

ObjectiveDifferentiation of oligodendroglial precursor cells is crucial for central nervous system remyelination and is influenced by both extrinsic and intrinsic factors. Recent studies showed that human endogenous retrovirus type W (HERV‐W) contributes significantly to brain damage. In particular, its envelope protein ENV can mediate injury to specific cell types of the brain and immune system. Here, we investigated whether ENV protein affects oligodendroglial differentiation.MethodsImmunostaining and gene expression analyses were performed to establish the expression and regulation of the known ENV receptor, Toll‐like receptor 4 (TLR4), on oligodendroglial precursor cells in human brain tissue and in culture. Cultured primary oligodendroglial precursor cells were stimulated with ENV protein to determine the effects of this ligand/receptor interaction.ResultsWe demonstrated that the ENV protein is present in close proximity to TLR4‐expressing oligodendroglial precursor cells adjacent to multiple sclerosis lesions. Human and rat oligodendroglial precursor cells expressed TLR4, and the ENV‐mediated activation of TLR4 led to the induction of proinflammatory cytokines and inducible nitric oxide synthase as well as the formation of nitrotyrosine groups and a subsequent reduction in myelin protein expression.InterpretationOur findings suggest that ENV‐mediated induction of nitrosative stress via activation of TLR4 results in an overall reduction of the oligodendroglial differentiation capacity, thereby contributing to remyelination failure. Therefore, pharmacological or antibody‐mediated inhibition of ENV may prevent the blockade of myelin repair in the diseased or injured central nervous system. Ann Neurol 2013;74:721–732