bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated preoperative plasma D-dimer level is an independent prognostic factor for pediatric patients with Wilms tumor
Authors: Qu Yu , Wang Hongwei , Wu Xiangyu , Wang Xiaoqing , Liu Wei , Wu Rongde 
Published: August 2024

ABSTRACT

Introduction:
Elevated plasma D-dimer levels are an unfavorable prognostic indicator for various tumors. However, its predictive value for prognosis in pediatric patients with Wilms tumor (WT) remains unknown. We aimed to investigate the clinical and prognostic value of preoperative plasma D-dimer levels and other clinicopathological characteristics in patients with favorable histology WT (FHWT).

Materials and Methods:
The clinical data of 74 children with FHWT from January 2010 to January 2022 were retrospectively analyzed. The clinicopathologic characteristics, preoperative laboratory parameter results, including D-dimer level, and follow-up data were collected. Based on the postoperative recovery status, the patients were divided into tumor-free survival and disease progression groups. The risk factors affecting disease progression in pediatric patients with WT and the impact of plasma D-dimer levels on overall survival (OS) were evaluated.

Results:
Over a median follow-up of 33 months (range: 2–145 months), 56 patients survived without progression. Relapses and metastases occurred in 18 patients, of which four survived and 14 died. Higher preoperative plasma D-dimer levels (>0.865) (Odds ratio [OR] = 7.240, 95% confidence interval (CI) = 1.276–33.272, P = 0.011) and tumor rupture (OR = 19.984, 95% CI = 1.182–338.013, P = 0.038) were independent prognostic factors for disease progression. Additionally, patients with elevated D-dimer levels demonstrated a worse 5-year OS than those with low D-dimer levels (Hazard ratio (HR) =4.278, 95% CI = 1.074–17.035, P = 0.039).

Conclusions:
Elevated D-dimer levels are a prognostic factor for a poorer outcome in pediatric patients with WT and are expected to become a clinical biomarker for predicting the prognosis of WT.
CT imaging-based nomogram for predicting early-stage glottic cancer recurrence following transoral laser microsurgery
Authors: Zhang Huanlei , Li Yuanyuan , Zhu Xuelin , Zhao Xiuli , Cong Lin 
Published: August 2024

ABSTRACT

Objective:
To explore the differences between clinical features and computed tomography (CT) findings of early-stage glottic cancer (EGC) with or without recurrence after transoral laser microsurgery (TLM) and to establish a preoperative nomogram to predict postoperative recurrence.

Methods:
The clinical and CT features of 168 consecutive patients with EGC with or without recurrence were analyzed retrospectively. Multivariate logistic regression analysis was used to determine the independent predictors of recurrence. A nomogram was constructed to preoperatively predict recurrence. To assess the nomogram’s performance, the C-index and calibration plot were used.

Results:
EGCs with and without recurrence differed significantly in T-stage, depth, and normalized CT values in the arterial phase (NCTAP) and venous phase (NCTVP) (all P < 0.05). T-stage, depth, and NCTVP were independent predictors of recurrence in EGCs (all P < 0.05). The C-index (0.765, 95% confidence interval: 0.703–0.827) and calibration plot showed that the nomogram has good prediction accuracy. Nomograms based on T-stage and CT variables provided numerically predicted recurrence rates and were better than those based on only T-stage (C-index of 0.765 vs. 0.608).

Conclusions:
Using clinical and CT variables, we developed a novel nomogram to predict the recurrence of EGC before TLM, which may be a potential noninvasive tool for guiding personalized treatment.
Computed tomography-guided radioactive iodine-125 seed implantation for liver malignancies in challenging locations
Authors: Li Lin , Tian Shuhui , Han Xujian , Tian Jing , Zhang Cunjing 
Published: August 2024

ABSTRACT

Aims:
This study aimed to retrospectively assess the safety and efficacy of radioactive iodine-125 (I-125) seed implantation for liver malignancies in challenging locations.

Materials and Methods:
Between December 2015 and December 2021, 49 patients with 60 liver malignancies in challenging locations who underwent computed tomography (CT)-guided I-125 seed implantation were retrospectively analyzed. The primary endpoints included technical success rate and overall survival (OS), whereas the secondary endpoints included progression-free survival (PFS), disease control rate (DCR), objective response rate (ORR), and liver recurrence. Potential factors associated with liver recurrence were also evaluated.

Results:
The technical success rate was 100%. The median follow-up duration was 12 months (range, 2–68 months). The mean OS and PFS were 17.58 months (95% CI: 13.64–21.52 months) and 13.14 months (95% CI: 10.36–15.92 months), respectively. The 2-month, 6-month, and 1-year DCR and ORR were 97.96% and 93.88%, 93.75% and 77.08%, and 93.48% and 60.87%, respectively. The 6- and 12-month tumor recurrence rates were 20.41% and 28.26%, respectively. The Kaplan–Meier method was used to estimate the time of liver recurrence, with our results showing that patients with primary intrahepatic cholangiocarcinoma had an increased likelihood of having earlier liver recurrence. No major complications developed during follow-up.

Conclusion:
CT-guided radioactive I-125 implantation could be a safe and effective alternative with promising survival benefits and high local control rates for liver malignancies in challenging locations.
Metastatic Melanocarcinoma – Cytomorphological Patterns
Authors: Garg Reetika , Bhake Arvind , Agrawal Anil 
Published: August 2024

Introduction:
The cytodiagnosis of melanocarcinoma achieved on Fine Needle Aspiration Cytology is cytomorphologically dicey at metastatic site. This is due to various morphologies achieved by melanocarcinoma as observed in histopathological examination. Therefore, it becomes imperative for cytopathologist to know about cytomorphological patterns observed at the diagnosis of melanocarcinoma. More so when melanocarcinoma is amelanotic and the clinical evidence of primary melanocarcinoma in the skin and other places is absent. Aim and Objectives: The present poster describes the experience with the cytomorphological patterns and diagnosis of melanocarcinoma, where the clinical evidence of presence of growth of melanocarcinoma in skin at any body site was absent.

Materials and Methods:
Fine needle aspiration done in 15 cases from metastatic sites, slides prepared were processed conventionaly.

Result and Conclusion:
It was observed that the certain cytomorphological features and typified cytomorphological arrangements in the presence of melanin containing cells or even amelanotic cells is enough characterizing melanocarcinoma which is described in the poster.
Psychosocial Impact of the Nationwide Lockdown on Undergraduate Engineering Students in Maharashtra
Authors: Tendolkar Vaishali Dinesh , Suraj Shaini , Panchbhai Aarati 
Published: August 2024

Background:
In the last few decades, mushrooming of technology institutes and engineering colleges has led to saturation of graduate engineers. For most technology and engineering graduates, the future seems gloomy and uncertain. With the recent worldwide recession, employability chances of many technology and engineering graduates have gone down. Survival of the most skilled is the thumb rule in recent years. The condition is further augmented by the COVID-19 pandemic and its consequences of the lockdown. The graduates pursuing technology education and engineering are badly affected by this phase.

Aim:
The current study aims at assessing the impact of lockdown due to COVID-19 on the psychosocial behavior of the technology and engineering students.

Study Design:
This is an online survey.

Study Population:
Technology and Engineering students in the age group of 17–25 years, both males and females.

Sample Size:
The sample size was 779.

Materials and Methods:
A psychological impact scale for students was developed by the investigators (r = 0.85). It is a 5-point scale with 0 as minimum score and 120 as the maximum possible score.

Results:
The mean age of the students was 20.49 ± 1.45 years. Nearly 95.4% of the students were living with their parents during this period of lockdown. Approximately 34.79% of the students experienced borderline negative impact, 18.74 reported mild negative impact, and 4.24% reported moderate negative impact of lockdown in just 30 days of the lockdown period. Most surprisingly, despite being with parents, 23.1% of the students had been out on roads during the lockdown.

Conclusion:
The lockdown has shown its adverse impact on the technology and engineering students. There is an urgent need to take steps to improve the employability of technology and engineering students. Else such a skilled workforce will be victim of psychological problems and a very important asset of the country shall be a waste.
Color Doppler Evaluation in High-Risk Pregnancies and Perinatal Outcome
Authors: Singh Harshika , Agrawal Manjusha , Bhake Arvind , Singh Ratnesh 
Published: August 2024

Introduction:
Doppler velocimetry is a rapid, noninvasive test that provides valuable information about the hemodynamic situation of the fetus and is an efficient diagnostic test of fetal jeopardy which helps in timely intervention and management of high-risk pregnancy for the better perinatal outcome.

Aim:
The aim of this study is to assess the role of color Doppler imaging in the prediction of high-risk pregnancies and their perinatal outcome.

Objectives:
The objecti evaluate the role of color Doppler in normal and high-risk pregnancies in relation to perinatal outcome.

Materials and Methods:
The study was carried out from August 1, 2016 to December 31, 2017 in the Department of Obstetrics and Gynecology in coordination with Central laboratory, and Department of Radiology, Jawaharlal Nehru Medical College Sawangi (M), Wardha, Maharashtra, India. A total of 120 pregnant women (study group and control group) attending a clinic in the Department of Gynecology and Obstetrics, AVBRH was examined for high-risk pregnancy.

Results:
There was a significant difference between the color Doppler indices of the three vessels (umbilical, uterine, and middle cerebral artery [MCA]) in the study and the control group. In women with abnormal Doppler indices, there was a high incidence of cesarean section, low-birth weight babies, low Apgar score, higher admission rate to neonatal intensive care unit.

Conclusion:
The color Doppler findings with abnormal indices of the uterine artery, umbilical artery, and MCA show a consistent relationship with poor perinatal outcome.
Ultrasound-Guided Femoral Nerve Block for Pain Management in Endovenous Laser Ablation for Varicose Vein
Authors: Singh Namrata , Banode Pankaj , Singh Amit Kumar 
Published: August 2024

Background:
Chronic venous insufficiency and its associated complications are a common condition affecting 15%–20% of the general population. Endovenous laser ablation (EVLA) is an effective day care treatment procedure. Tumescent anesthesia is given during EVLA to for pain relief and to prevent thermal damage to surrounding soft tissue by the laser energy. Regional nerve blocks can be given to reduce the pain of tumescent anesthesia and EVLA procedure. This study was aimed to evaluate pain score in varicose vein patients undergoing laser ablation with or without femoral nerve block.

Materials and Methods:
A total of 60 patients having only great saphenous vein disease were enrolled and divided into two Groups A and B using random number table. Group A was given tumescent anesthesia before laser EVLA procedure. Group B patients were given ultrasound guided femoral nerve block before tumescent anesthesia and laser ablation. Pain score was recorded intraoperatively, immediate and delated postoperative period (0, 1, and 3 h) on the Visual Analog Score. Data were analyzed using the standard statistical analysis tools.

Results:
Intraoperative and postoperative pain was significantly lower in Group B patients as compared to Group A (P < 0.0001). Volume of tumescent anesthesia used in Group B was significantly lower as compared to Group A.

Conclusion:
Femoral nerve block under ultrasound guidance is a safe, easy, and effective technique to reduce intra-operative and postoperative pain in patients undergoing EVLA without significant complications.
Effectiveness of the Buzzy Bee device on pain perception during invasive pricks among school age children: An interventional study
Authors: Al Battashi Ghadeer , AL-Shibli Zainab Said , Alghafri Abeer Issa , Alyazeedi Omar Mohammed , Alkalbani Ali Saif , Francis Frincy , Gopakumar G 
Published: August 2024

BACKGROUND:
Children often develop phobia toward needle pricks and invasive procedures. It is difficult for medical personnel to manage children’s pain when they are in the hospital. When it comes to assessing and treating children’s discomfort, nurses interact with them the most. The main objective of the study was to evaluate the effectiveness of the Buzzy Bee device on pain perception among children undergoing invasive needle pricks as part of their treatment.

MATERIALS AND METHODS:
The study used a quantitative approach with a quasi-experimental design employing simple random sampling. A post-test-only design was used. After obtaining ethical clearance, data collection was done in the pediatric outpatient department and pediatric wards of Sultan Qaboos University Hospital, Muscat, Oman, between February 2020 and August 2021. Faces Pain Rating Scale for children was used to rate the pain during the procedure, which is a standardized tool. Data were analyzed using SPSS version 23. Descriptive and inferential statistical tests were done to analyze the data.

RESULTS:
Totally, 120 children along with their parents were interested in the study. After taking appropriate parental consent and children’s assent, the participants were recruited by simple random sampling. They were equally divided into 60 in the experimental group and 60 in the control group. The mean age was 8.14 (+/-2.3) in both groups. Among the 120 samples, 63 (52.5%) of them were males and 57 (47.5%) were females. The majority of them had diagnoses like thalassemia, leukemia, and sickle cell and were getting cannulated for blood transfusion therapy. t-test shows that 51.7% (31 samples) reported no pain in the experimental group and 33.3% (20 samples) reported only mild pain, whereas in the control group, only 5.0% (3 samples) reported no pain and 21.7% (13 samples) reported mild pain. About 26.7% of the samples reported very much pain as against the 7% who reported very much pain in the interventional group. There was a statistically significant difference in the pain scores between the control group and the experimental group (likelihood ratio test, P = 0.0001). The Buzzy Bee method significantly reduced the pain.

CONCLUSION:
The introduction of a toy-like, child-friendly device, which works on the mechanism of vibrations and cold application, lessened the pain intensity during the procedure and acted as a good distractive therapy for children.
Community engagement in health promotion campaigns: A qualitative photo content analysis from vitalizing communities against NCD risk factors (V-CaN) field trial in rural central India
Authors: Samanthapudi Aditya V. , Wanjari Devyani , Sharma Radhika , Rajashekhar M , Kalantri Ashwini , Raut Abhishek V. , Gupta Subodh S. 
Published: August 2024

BACKGROUND:
India faces a critical challenge with 5.8 million annual deaths from non-communicable diseases (NCDs). Maharashtra, where NCDs constitute 66% of the disease burden. The youth, lacking awareness, are vulnerable. Vitalizing communities against NCD risk factors (V-CaN) melawa, inspired by the “Pandharpur Wari” pilgrimage, aims to bridge implementation gaps and empower communities. “Arogya chi wari” integrates health practices with cultural events, offering a unique approach. Photo documentation from V-CaN melawa becomes a powerful tool for assessing community engagement qualitatively. The aim of the study was to qualitatively analyze photos from V-CaN melawas, exploring community engagement in health promotion against NCD risk factors.

MATERIALS AND METHODS:
V-CaN melawas were organized in the field practice area of the department of community medicine. These melawas were part of the cluster randomized field trial named V-CaN, which is being implemented in a rural area of the Wardha district of Maharashtra. The V-CaN days, also known as melawas, were organized with the aim of facilitating behavioral change among participants. A qualitative study using photo content analysis was conducted, reviewing 2000 pictures from 59 V-CaN melawas. Thematic content analysis was employed, with researchers selecting 61 photos based on uniqueness.

RESULTS:
Six major themes emerged: health promotion, health system involvement, intersectoral coordination, inclusiveness, community resource mobilization, and innovation. Examples include nutrition exhibitions, health screenings, and innovative games.

CONCLUSIONS:
The analysis showcases diverse community participation in V-CaN melawas, emphasizing inclusivity, collaboration, and innovation. While qualitative, the study lays the foundation for future quantitative assessments of the intervention’s impact on health outcomes and community attitudes.
Attitude of the health team to the infant home care plan during the COVID-19 pandemic: A cross-sectional study
Authors: Sotoudeh Reza , Namnabati Mahbobeh , Heidarzadeh Mohammad , Toghyani Raheleh , Bahrami Niloofar 
Published: August 2024

BACKGROUND:
Maintaining and improving infant health and continuing care at home are very important for the health system. According to the coronavirus disease 2019 (COVID-19) pandemic and its effects on the health system capacity and medical staff’s physical-mental health, this study investigated the health staff’s attitude on the implementation of an infant home care plan.

MATERIALS AND METHODS:
This descriptive-analytical cross-sectional study was conducted on 130 nurses, midwives, and doctors working in the newborn care department in Isfahan health-therapeutic centers, with at least 6 months of work experience. The samples were selected by random multistage method and completed the researcher-made 5-point Likert questionnaire with 25 items and two areas of education support and security safety. The total score of this questionnaire varied from 25 to 125, and obtaining a score equal to or greater than 91 meant that people had a favorable opinion about home care for babies. The reliability of the questionnaire was reported by Cronbach’s α of 0.79, and content validity ratio (CVR) and content validity index (CVI) scores of 0.88–0.99 and 0.79–0.1, respectively. Data analysis was performed using the Statistical Package for the Social Sciences version 18.0 (SPSS) (Chicago, USA) and analysis of descriptive statistics, Chi-square, and Pearson correlation tests at a 0.05 significance level.

RESULTS:
The mean score of medical staff's attitude was obtained at 77.59 ± 11.71 and the security-safety and education-support domains scores were 41.3 ± 6.34 and 36.29 ± 6.11, respectively. In addition, a significant inverted relationship was observed between the mean score of medical staffs’’attitude with age and the number of shifts.

CONCLUSION:
According to the results, the medical staff's attitude about the infant home care program is neutral, and designing a professional educational period, considering economic preparations and responsibility assurance is essential for creating confidence and acceptance of the infant home care program by the medical staff.
Appraisal the structure of diabetes self-management education and support in diabetes education units of Isfahan, Iran
Authors: Alijani Marzieh , Siavash Mansour , Abazari Parvaneh 
Published: August 2024

BACKGROUND:Diabetes self-management education and support (DSMES) is an approach to improve preventive practices and behaviors with a focus on decision-making, problem-solving, and self-care. The present study was designed to appraisal structural standards of Diabetes Self-Management Education (DSME) in Isfahan province.MATERIALS AND METHODS:The sample size included 170 files of patients with diabetes in 31 diabetes education units. The data collection tools were a checklist with 62 items and a questionnaire. Data was collected via observation and interview. In each diabetes education unit, theresearcherfirst observed the physical space and equipment of the classroom and completed the relevant items in the checklist. Then participated in one individual and one group education session and completed the checklist withthe relevant items. At the end of the session, the researcher completed the questionnaire by interviewing the educator. The collected data were described using SPSS version 21 software.RESULTS:Regarding the characteristics of educators. All of them had started working as an educator without completing the diabetes education courseandabout a third of them had less than one year of work experience (29%) in diabetes units. Regarding physical space, about 90% of the education units had proper lighting, cooling and heating devices, and less than half (48.4%) had proper ventilation. In 3.2% of diabetes units, educators had access to the Internet. In none of the diabetes education units(%0), there was an up-to-date and evidence-based documented curriculum.CONCLUSION:The results of the present study showed serious challenges in the field of the structure of DSMES in the diabetes education units of Isfahan province. Considering the necessity and critical importance of diabetes education, policymakers in the field of diabetes management can benefit fromthese results for planning to help improve this situation.
Identification of key factors affecting the future of knowledge translation in Iranian health policy-making
Authors: Mojiri Shahin , Soleymani Mohammad Reza , Sajadi Haniye Sadat , Ashrafi-Rizi Hasan , Sahebzadeh Mandana , Demneh Mohsen Taheri 
Published: August 2024

BACKGROUND:
Production, publication, and effective of academic research in health policy-making are tools to strengthen interactions between policy-makers, the scientific community, and the public. The purpose of this study was to identify the key factors of knowledge translation in the policy-making of the health system in Iran using the structural analysis method.

MATERIALS AND METHODS:
This future study was conducted using the foresight structural analysis method for a 10-year horizon in Iran from 2022 to 2031. Initially, 183 factors were identified by literature review and interviews with experts. In the next step, factors were reduced to 34 factors based on the research team’s opinions by merging similar items and removing fewer related items. Then, 34 factors were sent to the experts through an online questionnaire. Nineteen factors were identified with importance and uncertainty above the average. Then, the average degree of cross-impact of the selected factors in the matrix was scored by 11 experts in a focus group meeting, ranged from 3 (strong) to 1 (weak). The cross-impact of these factors was analyzed using MICMAC software.

RESULTS:
Five factors, including “policy-making method,” “role and function of universities,” “specialized services of knowledge brokering,” “international conflicts,” and “policy-makers’ trust in university researches,” were identified as key factors due to their high influence and effectiveness.

CONCLUSION:
The results of this study will help the research managers of the universities to be more informed and, therefore, more successful in their planning for more efficient utilization of the knowledge and evidence from academic research by knowing the factors influencing the translation of knowledge.