bluuebunny/crossref_metadata_2025_split huggingface dataset:
EEG/MEG source imaging of deep brain activity within the maximum entropy on the mean framework: Simulations and validation in epilepsy
Authors: Afnan Jawata , Cai Zhengchen , Lina Jean‐Marc , Abdallah Chifaou , Delaire Edouard , Avigdor Tamir , Ros Victoria , Hedrich Tanguy , von Ellenrieder Nicolas , Kobayashi Eliane , Frauscher Birgit , Gotman Jean , Grova Christophe 
Published: July 2024

AbstractElectro/Magneto‐EncephaloGraphy (EEG/MEG) source imaging (EMSI) of epileptic activity from deep generators is often challenging due to the higher sensitivity of EEG/MEG to superficial regions and to the spatial configuration of subcortical structures. We previously demonstrated the ability of the coherent Maximum Entropy on the Mean (cMEM) method to accurately localize the superficial cortical generators and their spatial extent. Here, we propose a depth‐weighted adaptation of cMEM to localize deep generators more accurately. These methods were evaluated using realistic MEG/high‐density EEG (HD‐EEG) simulations of epileptic activity and actual MEG/HD‐EEG recordings from patients with focal epilepsy. We incorporated depth‐weighting within the MEM framework to compensate for its preference for superficial generators. We also included a mesh of both hippocampi, as an additional deep structure in the source model. We generated 5400 realistic simulations of interictal epileptic discharges for MEG and HD‐EEG involving a wide range of spatial extents and signal‐to‐noise ratio (SNR) levels, before investigating EMSI on clinical HD‐EEG in 16 patients and MEG in 14 patients. Clinical interictal epileptic discharges were marked by visual inspection. We applied three EMSI methods: cMEM, depth‐weighted cMEM and depth‐weighted minimum norm estimate (MNE). The ground truth was defined as the true simulated generator or as a drawn region based on clinical information available for patients. For deep sources, depth‐weighted cMEM improved the localization when compared to cMEM and depth‐weighted MNE, whereas depth‐weighted cMEM did not deteriorate localization accuracy for superficial regions. For patients' data, we observed improvement in localization for deep sources, especially for the patients with mesial temporal epilepsy, for which cMEM failed to reconstruct the initial generator in the hippocampus. Depth weighting was more crucial for MEG (gradiometers) than for HD‐EEG. Similar findings were found when considering depth weighting for the wavelet extension of MEM. In conclusion, depth‐weighted cMEM improved the localization of deep sources without or with minimal deterioration of the localization of the superficial sources. This was demonstrated using extensive simulations with MEG and HD‐EEG and clinical MEG and HD‐EEG for epilepsy patients.
Awareness of embodiment enhances enjoyment and engages sensorimotor cortices
Authors: Moffat Ryssa , Cross Emily S. 
Published: July 2024

AbstractWhether in performing arts, sporting, or everyday contexts, when we watch others move, we tend to enjoy bodies moving in synchrony. Our enjoyment of body movements is further enhanced by our own prior experience with performing those movements, or our ‘embodied experience’. The relationships between movement synchrony and enjoyment, as well as embodied experience and movement enjoyment, are well known. The interaction between enjoyment of movements, synchrony, and embodiment is less well understood, and may be central for developing new approaches for enriching social interaction. To examine the interplay between movement enjoyment, synchrony, and embodiment, we asked participants to copy another person's movements as accurately as possible, thereby gaining embodied experience of movement sequences. Participants then viewed other dyads performing the same or different sequences synchronously, and we assessed participants' recognition of having performed these sequences, as well as their enjoyment of each movement sequence. We used functional near‐infrared spectroscopy to measure cortical activation over frontotemporal sensorimotor regions while participants performed and viewed movements. We found that enjoyment was greatest when participants had mirrored the sequence and recognised it, suggesting that awareness of embodiment may be central to enjoyment of synchronous movements. Exploratory analyses of relationships between cortical activation and enjoyment and recognition implicated the sensorimotor cortices, which subserve action observation and aesthetic processing. These findings hold implications for clinical research and therapies seeking to foster successful social interaction.
Cultural blind spots: Identifying hidden psychosocial hazards in the workplace
Authors: Kiaos Theaanna 
Published: July 2024

AbstractIssue AddressedThis article presents a framework to identify hidden psychosocial hazards and emerging mental health risks in the workplace, thereby assisting Persons Conducting a Business or Undertaking. The framework adds value to the processes outlined in SafeWork NSW's Code of Practice for Managing Psychosocial Hazards At Work. Specifically, the article documents a framework to analyse microcultures and back stage sites of enactment where psychosocial hazards and risks may be hidden or obscured in workplace settings.BackgroundThe article's framework aims to bring to the surface both the intra and interpersonal tensions employees experience in the social reality they inhabit while they perform their work, thereby positively contributing to organisations and PCBUs by helping them create healthy workplace cultures and psychological safety.MethodsSpecifically, the article discusses partnering with an organisational ethnographer when a PCBU embarks upon psychosocial investigations to: gain access, select employee participants, start conversations, establish rapport, build trust, collect and analyse data.ConclusionThis article theoretically contributes to health promotion literatures by offering organisations a complementary way of extracting deeper insights and understandings of psychosocial hazards and emerging mental health risks which are not apparent with traditional methods of inquiry.
Bi‐directional and multi‐modal effects of dexamphetamine on spatial binding windows in healthy individuals
Authors: Lim Mark J. H. , Loffman Sean J. , Gaus Katharina , Slawik Sophie V. , Iyyalol Rajan , Lee Joseph W. Y. , Hepple Emily K. , Martin‐Iverson Mathew T. 
Published: July 2024

AbstractObjectivesStimuli that are separated by a short window of space or time, known as spatial and temporal binding windows (SBW/TBWs), may be perceived as separate. Widened TBWs are evidenced in schizophrenia, although it is unclear if the SBW is similarly affected. The current study aimed to assess if dexamphetamine (DEX) may increase SBWs in a multimodal visuo‐tactile illusion, potentially validating usefulness as an experimental model for multimodal visuo‐tactile hallucinations in schizophrenia, and to examine a possible association between altered binding windows (BWs) and working memory (WM) suggested by previous research.MethodsA placebo‐controlled, double‐blinded, and counter‐balanced crossover design was employed. Permuted block randomisation was used for drug order. Healthy participants received DEX (0.45 mg/kg, PO, b.i.d.) or placebo (glucose powder) in capsules. The Rubber Hand Illusion (RHI) and Wechsler Adult Intelligence Scale Spatial Span was employed to determine whether DEX would alter SBWs and WM, respectively. Schizotypy was assessed with a variety of psychological scales.ResultsMost participants did not experience the RHI even under normal circumstances. Bi‐directional and multimodal effects of DEX on individual SBWs and schizotypy were observed, but not on WM.ConclusionsBidirectional multimodal effects of DEX on the RHI and SBWs were observed in individuals, although not associated with alterations in WM.
A proteome‐wide analysis unveils a core Epstein–Barr virus antibody signature of classic Hodgkin lymphoma across ethnically diverse populations
Authors: Sarathkumara Yomani D. , Xian Rena R. , Liu Zhiwei , Yu Kelly J. , Chan John K. C. , Kwong Yok‐Lam , Lam Tai Hing , Liang Raymond , Chiu Brian , Xu Jun , Hu Wei , Ji Bu‐Tian , Coghill Anna E. , Kelly Ashton M. , Pfeiffer Ruth M. , Rothman Nathaniel , Ambinder Richard F. , Hildesheim Allan , Lan Qing , Proietti Carla , Doolan Denise L. 
Published: July 2024

AbstractEpstein–Barr virus (EBV) is an oncogenic virus associated with various malignancies, including classical Hodgkin lymphoma (cHL). Despite its known association, the specific role of humoral immune response to EBV remains poorly characterized in cHL. To address this, we conducted a study using a custom protein microarray to measure the antibody responses in cHL patients and matched healthy controls recruited from an East‐Asian hospital‐based case–control study. We identified 16 IgG antibodies significantly elevated in EBV‐positive cHL compared with controls, defining an “East‐Asian antibody signature of EBV‐positive cHL.” We evaluated responses against these 16 antibodies in a distinct European population, leveraging data from our previous European cHL case–control study from the UK, Denmark, and Sweden. A subset of antibodies (14/16, 87.5%) from the “East‐Asian antibody signature of EBV‐positive cHL” exhibited significant associations with cHL in the European population. Conversely, we assessed the “European antibody signature of EBV‐positive cHL” identified in our prior study which consisted of 18 EBV antibodies (2 IgA, 16 IgG), in the East‐Asian population. A subset of these antibodies (15/18, 83.3%) maintained significant associations with cHL in the East‐Asian population. This cross‐comparison of antibody signatures underscores the robust generalizability of EBV antibodies across populations. Five anti‐EBV IgG antibodies (LMP‐1, TK, BALF2, BDLF3, and BBLF1), found in both population‐specific antibody signatures, represent a “core signature of EBV‐positive cHL.” Our findings suggest that the antibody responses targeting these core EBV proteins reflect a specific EBV gene expression pattern, serving as potential biomarkers for EBV‐positive cHL independent of population‐specific factors.
Three biomarkers (HER2, PD‐L1, and microsatellite status) in a large cohort of metastatic gastroesophageal adenocarcinomas: The MD Anderson Cancer Center experience
Authors: Sewastjanow‐Silva Matheus , Kwiatkowski Evan , Yamashita Kohei , Abdelhakeem Ahmed , Yoshimura Katsuhiro , Vicentini Ernesto R. , Pizzi Melissa P. , Jin Jiankang , Fan Yibo , Zou Gengyi , Wang Lingzhi , Yin Feng , Dhar Shilpa S. , Blum Murphy Mariela , Mares Jeannette E. , Li Jenny J. , Gan Qiong , Waters Rebecca E. , Rogers Jane E. , Ajani Jaffer A. 
Published: July 2024

AbstractHuman epidermal growth factor receptor‐2 (HER2), programmed death‐ligand 1 (PD‐L1), and microsatellite (MS) status are well‐established biomarkers in gastroesophageal adenocarcinomas (GEAs). However, it is unclear how the combination of these biomarkers is associated with clinicopathological factors and prognosis. This retrospective study included baseline metastatic GEA patients who were tested for all three biomarkers (HER2, PD‐L1, and MS status) at the MD Anderson Cancer Center between 2012 and 2022. Stratification was performed according to the combination of biomarker profiles: triple negative (TN), single positive (SP), and multiple positive (MP). Comparative analyses of clinicopathological factors and survival using combinations of biomarkers were performed. Among the 698 GEA patients analyzed, 251 (36.0%) were classified as TN, 334 (47.9%) as SP, and 113 (16.1%) as MP. The MP group showed a significant association with tumors located in the esophagus (p < .001), well to moderate differentiation (p < .001), and the absence of signet ring cells (p < .001). In the survival analysis, MP group had a significantly longer overall survival (OS) compared to the other groups (MP vs. TN, p < .001 and MP vs. SP, p < .001). Multivariate Cox regression analysis revealed that MP serves as an independent positive prognostic indicator for OS (hazard ratio = 0.63, p < .01). Our findings indicate that MP biomarkers are associated with a favorable prognosis in metastatic GEA. These results are reflective of clinical practice and offer valuable insights into how therapeutics and future biomarkers could influence therapy/prognosis.
Association between risk of infant death and birth‐weight z scores according to gestational age: A nationwide study using the Finnish Medical Birth Register
Authors: Hocquette Alice , Pulakka Anna , Metsälä Johanna , Heikkilä Katriina , Zeitlin Jennifer , Kajantie Eero 
Published: July 2024

AbstractObjectiveTo investigate the association between infant mortality and birth weight using estimated fetal weight (EFW) versus birth‐weight charts, by gestational age (GA).MethodsThis nationwide population‐based study used data from the Finnish Medical Birth Register from 2006 to 2016 on non‐malformed singleton live births at 24–41+6 weeks of gestation (N = 563 630). The outcome was death in the first year of life. Mortality risks by birth‐weight z score, defined as a continuous variable using Maršál's EFW and Sankilampi's birth‐weight charts, were assessed using generalized additive models by GA (24–27+6, 28–31+6, 32–36+6, 37–38+6, 39–41+6 weeks). We calculated z score thresholds associated with a two‐ and three‐fold increased risk of infant death compared with newborns with a birth weight between 0 and 0.675 standard deviations.ResultsThe z score thresholds (with corresponding centiles in parentheses) associated with a two‐fold increase in infant mortality were: −3.43 (<0.1) at 24–27+6 weeks, −3.46 (<0.1) at 28–31+6 weeks, −1.29 (9.9) at 32–36+6 weeks, −1.18 (11.9) at 37–38+6 weeks, and − 1.34 (9.0) at 39–41+6 weeks according to the EFW chart. These values were − 2.43 (0.8), −2.62 (0.4), −1.34 (9.0), −1.37 (8.5), and − 1.43 (7.6) according to the birth‐weight chart.ConclusionThe association between birth weight and infant mortality varies by GA whichever chart is used, suggesting that different thresholds for the screening of growth anomalies could be used across GA to identify high‐risk newborns.
Different endometrial preparation protocols on first frozen–thawed embryo transfer outcomes after hysteroscopic polypectomy: A retrospective cohort study
Authors: Ji Hui , Zhou Qiao , Zhang Song , Dong Li , Zhao Chun , Ling Xiu‐feng 
Published: July 2024

AbstractObjectiveTo evaluate the optimal endometrial preparation protocol for frozen–thawed embryo transfer (FET) following hysteroscopic polypectomy.MethodsThis was a retrospective clinical cohort study involving 464 patients who underwent their first FET after polyp resection between January 2021 and July 2023. The cohorts were categorized into three groups: the natural cycle (NC) group (n = 139), the ovarian induction (OI) group (n = 117), and the hormone replacement therapy (HRT) group (n = 208).ResultsIn the initial unadjusted analysis, both NC and OI cycles exhibited similar pregnancy rates but were associated with significantly higher implantation rate (56.5%, 57.1% vs 42.0%, P < 0.001), clinical pregnancy rate (73.4%, 74.4% vs 57.2%, P = 0.001), and ongoing pregnancy rate (OPR; 67.6%, 63.2% vs 51.0%, P = 0.005) compared to the HRT group. Additionally, the three groups demonstrated comparable abortion rate (7.8%, 14.9% vs 10.9%, P = 0.299). After adjusting for potential confounders in the multiple logistic regression model, the HRT protocol resulted in a 54% significantly lower OPR compared to the NC protocol (adjusted odds ratio [aOR] = 0.46, 95% confidence interval [CI]: 0.28–0.77; P = 0.003). Meanwhile, the OPR difference between the OI protocol and the NC protocol remained insignificant (OI vs NC: aOR = 0.62, 95% CI: 0.35–1.12; P = 0.112).ConclusionThe ovulatory‐FET scheme (NC and OI) following hysteroscopic polyp resection displayed promising clinical outcomes compared with HRT‐FET scheme. The regimen without exogenous estrogen administration should be prioritized for endometrial preparation protocol after polypectomy.
Providing optimal cropping patterns and water consumption according to monitored and forecasted drought conditions
Authors: Khajehi Farzaneh , Moghimi Mohammad Mehdi , Zarei Abdol Rassoul 
Published: July 2024

AbstractDrought management in the agricultural sector requires monitoring and prediction of this phenomenon, as well as providing a suitable cropping pattern. In this study, the reconnaissance drought index (RDI) was used for drought monitoring in Fars Province, Iran. The status of water resources was predicted using a model that matches the time series of the RDI and the groundwater level. The optimal cropping pattern was obtained according to the predicted available water resources using a genetic algorithm. Generally, the actual and predicted changes in groundwater levels indicate the critical conditions of groundwater resources in the study area. Groundwater resource consumption should be lowered by implementing deficit irrigation scenarios that result in keeping crops with lower sensitivity to water deficit in cropping patterns such as barley, wheat, canola, forage corn and potato. The cropping pattern optimization results suggest an increase in the area allocated to more economical crops in the northern half of Fars Province due to the better temporal distribution of annual rainfall and better water resource conditions. However, with increasing water costs, the cultivation area and the optimal water reduction fraction of these plants decreased.
A practical solution to improve the field of view in circular scanning‐based photoacoustic tomography
Authors: Ranjbaran Seyed Mohsen , Zafar Mohsin , Saint‐Martin Loïc , Islam Md Tarikuls , Avanaki Kamran 
Published: July 2024

AbstractOne of the primary challenges in ring single‐element photoacoustic tomography systems is the low image quality in areas away from the center of the ring. This is mainly due to the limited field of view (FOV) of each transducer, which in turn reduces the imaging FOV. To address this shortcoming, we have put forward a practical and straightforward solution to enhance the FOV of circular scanning‐based photoacoustic tomography (CS‐PAT). This is accomplished by placing transducers at different angles instead of using a single transducer placed at a normal angle to the imaging target. We also modified the ring scanner inner wall surface to significantly reduce photoacoustic reverberation. By imaging several phantoms, we show a significant improvement in the images generated by our system imaging from 4.1 to over 7 for the signal‐to‐noise ratio and structural similarity index increased from 41% to 70%.
Examining the mediating role of e‐health literacy in the relationship between COVID‐19 awareness and dispositional hope and the experiences of those who survived the disease
Authors: Gunlu Aykut 
Published: July 2024

AbstractThe aim of this study was to examine the mediating effect of e‐health literacy levels on the relationship between individuals' awareness of COVID‐19 and dispositional hope during the COVID‐19 pandemic. The research was conducted with a mixed‐methods design. Quantitative data were collected for the study online using Google Forms and qualitative data were collected online with an interview technique. In this framework, the qualitative data were obtained from a total of 15 people who had been diagnosed with COVID‐19. These participants were selected using the snowball sampling method. A personal information form, e‐Health Literacy Scale, Coronavirus Awareness Scale, Dispositional Hope Scale, and semistructured interview form were utilized in the course of the research. As a result of, it was determined that there were significant relationships between coronavirus awareness and both e‐health literacy and dispositional hope, as well as between e‐health literacy and dispositional hope. The measurement model was found to have good fit values. Testing the structural equation model, it was determined that e‐health literacy had a full mediating role between coronavirus awareness and dispositional hope. In addition, this study showed that people who had COVID‐19 had increased awareness of COVID‐19 after contracting the disease.
Do phosphorus amendments enhance biodegradation activity in stalled petroleum hydrocarbon‐contaminated soil?
Authors: Schryer Aimée D. , Siciliano Steven D. 
Published: July 2024

AbstractPhosphorus (P) fertilizers promote soil petroleum‐hydrocarbon (PHC) bioremediation by correcting carbon‐to‐P ratio imbalances. While these inputs create conditions favorable to microbial growth, areas of a site or an entire site with low degradation rates (i.e., “stalled”) occur for unknown reasons. We hypothesized that soil conditions limit P bioavailability, leading to stalls in PHC bioremediation, and adding the correct P amendment restarts microbial activity. Soils were collected and characterized from four cold calcareous PHC‐impacted sites in Saskatchewan, Canada, undergoing bioremediation. A generalized linear mixed model identified that regions with lower degradation rates possessed a neutral pH with high magnetic and salinity values. In a subsequent laboratory experiment, the proportion of benzene degraded at greater rates within active (i.e., higher degradation rates) than stalled soils, thereby following model predictions (p‐value = 0.19, Kruskal–Wallis). The PHC degradation efficiency of different P amendments was tested by doping stalled soils (n = 3) with one of five treatments: 0 (control), 0 (autoclaved control), or 50 mg phosphate kg−1 soil as sodium diphosphate, triethyl phosphate, or tripolyphosphate. Tripolyphosphate accelerated benzene degradation (75.5 ± 5.4%) in one stalled soil (Outlook 323) and increased degradation non‐significantly (43.9 ± 9.4%) in another (Allan 917). Alternatively, the final sample (Davidson 421) possessed the greatest benzene removal with no amendments. This implies that soil P bioavailability may not be the sole cause of decreased microbial activity. Accordingly, combining model outputs with mineralogy and microbiology investigations could enhance PHC biodegradation rates in these cold calcareous soils.
Mechanisms underlying episodic nitrate and phosphorus leaching from poorly drained agricultural soils
Authors: Lawrence Nathaniel C. , Hall Steven J. 
Published: July 2024

AbstractPoorly drained depressions within tile‐drained croplands can have disproportionate environmental and agronomic impacts, but mechanisms controlling nutrient leaching remain poorly understood. We monitored nitrate and soluble reactive phosphorus (SRP) leaching using zero‐tension soil lysimeters across a depression to upland gradient over 2 years in a corn–soybean (Zea mays L.–Glycine max [L.] Merr.) field in Iowa. We also measured stable isotopes (δ15N and δ18O) of nitrate to examine its sources and transformations. SRP concentrations peaked during winter and early spring after phosphorus (P) fertilization (mean = 3 mg P L−1), with highest values in the depression, and SRP was relatively stable thereafter (mean = 0.3 mg P L−1) irrespective of periods of high soil moisture that led to widespread iron (Fe) reduction across the field. During a near‐average precipitation year, nitrate stable isotopes indicated direct leaching of fertilizer nitrate within days of application, followed by nitrification of fertilizer ammonium and several weeks of denitrification in depressional soils. Nevertheless, nitrate concentrations remained high (mean = 28 mg N L−1) in the depression despite strong isotopic evidence for denitrification (>48% N removal). During a wet year, nitrate concentrations were lower in the depression than upland and nitrate isotopes were highly variable, consistent with nearly complete nitrate removal by denitrification in the depression and significant denitrification in upland soils. We conclude that poorly drained depressional soils can potentially decrease nitrate leaching via denitrification under sustained wet conditions, but they inconsistently denitrify and are vulnerable to high nitrate and SRP losses when soils are not saturated, especially following fertilization.