bluuebunny/crossref_metadata_2025_split huggingface dataset:
Associated factors with voriconazole plasma concentration: a systematic review and meta-analysis
Authors: Li Xiaoqi , Hu Qiaozhi , Xu Ting 
Published: August 2024

Background: Voriconazole plasma concentration exhibits significant variability and maintaining it within the therapeutic range is the key to enhancing its efficacy. We conducted a systematic review and meta-analysis to estimate the prevalence of patients achieving the therapeutic range of plasma voriconazole concentration and identify associated factors.Methods: Eligible studies were identified through the PubMed, Embase, Cochrane Library, and Web of Science databases from their inception until 18 November 2023. We conducted a meta-analysis using a random-effects model to determine the prevalence of patients who reached the therapeutic plasma voriconazole concentration range. Factors associated with plasma voriconazole concentration were summarized from the included studies.Results: Of the 60 eligible studies, 52 reported the prevalence of patients reaching the therapeutic range, while 20 performed multiple linear regression analyses. The pooled prevalence who achieved the therapeutic range was 56% (95% CI: 50%–63%) in studies without dose adjustment patients. The pooled prevalence of adult patients was 61% (95% CI: 56%–65%), and the pooled prevalence of children patients was 55% (95% CI: 50%–60%) The study identified, in the children population, several factors associated with plasma voriconazole concentration, including age (coefficient 0.08, 95% CI: 0.01 to 0.14), albumin (−0.05 95% CI: −0.09 to −0.01), in the adult population, some factors related to voriconazole plasma concentration, including omeprazole (1.37, 95% CI 0.82 to 1.92), pantoprazole (1.11, 95% CI: 0.17–2.04), methylprednisolone (−1.75, 95% CI: −2.21 to −1.30), and dexamethasone (−1.45, 95% CI: −2.07 to −0.83).Conclusion: The analysis revealed that only approximately half of the patients reached the plasma voriconazole concentration therapeutic range without dose adjustments and the pooled prevalence of adult patients reaching the therapeutic range is higher than that of children. Therapeutic drug monitoring is crucial in the administration of voriconazole, especially in the children population. Particular attention may be paid to age, albumin levels in children, and the use of omeprazole, pantoprazole, dexamethasone and methylprednisolone in adults.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023483728.
Watercress oil loaded with gel: evaluation of hemolysis inhibition, antioxidant, antimicrobial, and healing properties
Authors: Alharbi Bandar , Qanash Husam , Almashjary Majed N. , Barnawi Heba , Aldarhami Abdu , Alsaif Ghaida , Alsamaan Fahad , Monjed Mohammad Khalil , Al Shmrany Humood , Bazaid Abdulrahman S. 
Published: August 2024

Plant-derived compounds are renowned for their remarkable pharmacological properties, holding immense promise for therapeutic interventions in human health. In this study, we aimed to assess the antimicrobial, anti-hemolytic, antioxidant, and wound healing attributes of watercress oil incorporated into Vaseline gel (OLG) compared to watercress oil alone. OLG was formulated through a meticulous process involving the addition of Vaseline gel to the oil under agitation conditions. High-performance liquid chromatography analysis of watercress oil unveiled a rich array of phenolic compounds, including gallic acid (10.18 μg/mL), daidzein (3.46 μg/mL), and hesperetin (3.28 μg/mL). The inhibitory zones caused by watercress oil alone against a spectrum of pathogens, including Staphylococcus aureus, Escherichia coli, Klebsiella pneumoniae, Enterococcus faecalis, and Candida albicans, were measured at 25 ± 0.3, 26 ± 0.1, 22 ± 0.2, 25 ± 0.2, and 24 ± 0.1 mm, respectively. Notably, OLG exhibited slightly larger zones of inhibition (27 ± 0.2, 30 ± 0.2, 24 ± 0.1, 28 ± 0.1, and 25 ± 0.3 mm) against the same microbial strains. Furthermore, the minimum inhibitory concentration (MIC) of OLG against E. coli and E. faecalis was lower compared to watercress oil alone, indicating enhanced efficacy. Similarly, the minimum bactericidal concentration (MBC) of OLG was notably lower across all tested bacteria compared to watercress oil alone. Inhibition of bacterial hemolysis, particularly K. pneumoniae, was significantly enhanced with OLG treatment, showcasing reductions of 19.4%, 11.6%, and 6.8% at 25%, 50%, and 75% MIC concentrations, respectively, compared to watercress oil alone. The antioxidant activity of both oil and OLG was quantified with IC50 values of 2.56 and 3.02 μg/mL, respectively. Moreover, OLG demonstrated remarkable efficacy in wound healing assays, with notable enhancements in migration rate, wound closure, and area difference compared to control cells. In light of the observed antibacterial, antifungal, anti-hemolytic, and wound healing properties of OLG, this formulation holds therapeutic potential in treating microbial infections and promoting wound healing.
Design and evaluation of magnetic-targeted bilosomal gel for rheumatoid arthritis: flurbiprofen delivery using superparamagnetic iron oxide nanoparticles
Authors: Mushtaq Rayan Y. , Naveen Nimbagal Raghavendra , Rolla Krishna Jayanth , Al Shmrany Humood , Alshehri Sameer , Salawi Ahmad , Kurakula Mallesh , Alghamdi Majed A. , Rizg Waleed Y. , Bakhaidar Rana B. , Abualsunun Walaa A. , Hosny Khaled M. , Alamoudi Abdulmohsin J. 
Published: August 2024

IntroductionThe study aimed to systematically enhance the fabrication process of flurbiprofen-loaded bilosomes (FSB) using Quality by Design (QbD) principles and Design of Experiments (DOE). The objective was to develop an optimized formulation with improved entrapment efficiency and targeted drug delivery capabilities.MethodsThe optimization process involved applying QbD principles and DOE to achieve the desired formulation characteristics. Superparamagnetic iron oxide nanoparticles (SPIONs) were incorporated to impart magnetic responsiveness. The size, entrapment efficiency, morphology, and in vitro release patterns of the FSB formulation were evaluated. Additionally, an in situ forming hydrogel incorporating FSB was developed, with its gelation time and drug release kinetics assessed. In vivo studies were conducted on osteoarthritic rats to evaluate the efficacy of the FSB-loaded hydrogel.ResultsThe optimized FSB formulation yielded particles with a size of 453.60 nm and an entrapment efficiency of 91.57%. The incorporation of SPIONs enhanced magnetic responsiveness. Morphological evaluations and in vitro release studies confirmed the structural integrity and sustained release characteristics of the FSB formulation. The in situ forming hydrogel exhibited a rapid gelation time of approximately 40 ± 1.8 s and controlled drug release kinetics. In vivo studies demonstrated a 27.83% reduction in joint inflammation and an 85% improvement in locomotor activity in osteoarthritic rats treated with FSB-loaded hydrogel.DiscussionThis comprehensive investigation highlights the potential of FSB as a promising targeted drug delivery system for the effective management of osteoarthritis. The use of QbD and DOE in the formulation process, along with the integration of SPIONs, resulted in an optimized FSB formulation with enhanced entrapment efficiency and targeted delivery capabilities. The in situ forming hydrogel further supported the formulation’s applicability for injectable applications, providing rapid gelation and sustained drug release. The in vivo results corroborate the formulation’s efficacy, underscoring its potential for improving the treatment of osteoarthritis.
Factor structure and measurement invariance of the University Demand-Resource Questionnaire: further evidence from Hungarian university students
Authors: Sun Guo-Dong , Chen Hua-Ke , Sun Wei-Xing , Szabó Éva , Tóth Enikő , Hu Jin-Chuan , Jagodics Balázs , Liu Jing-Dong 
Published: August 2024

PurposeThe present study aimed to further examine the factor structure and measurement invariance of the UDRQ among a sample of Hungarian university students.MethodsFirstly, the factor structure of the UDRQ was examined among 837 Hungarian university students. Specifically, two measurement models (first-order model and second-order model) were constructed and compared. Secondly, the internal consistency reliability of the UDRQ was examined. Thirdly, measurement invariance of the UDRQ was evaluated across genders. Finally, measurement invariance of the UDRQ was evaluated across two different samples.ResultsIt was found that the first-order model outperformed the second-order model and better represented the factor structure of the UDRQ subscales. Results of Cronbach’s alpha and Composite Reliability suggested that the internal consistency reliabilities of the two UDRQ subscales were satisfactory. Measurement invariance analysis revealed that the UDRQ measurement model was strict invariant across genders and samples.ConclusionThe findings of the present study indicated that the UDRQ displayed satisfactory reliability and validity and could be used to assess demands and resources of Hungarian university students.
Combined impact of elevated C-reactive protein levels and dyslipidemia on stroke: a CHNS prospective cohort study
Authors: Lv Meiru , Su Chang , Huang Feifei , Jia Xiaofang , Zhang Jiguo , Wang Huijun , Wu Xiaoyu , Zhou Weiwei , Du Wenwen 
Published: August 2024

BackgroundThe objective of this study was to examine whether the combination of elevated levels of C-reactive protein (CRP) and dyslipidemia increased the risk of stroke among middle-aged and older adult individuals in China.MethodsThis study utilized longitudinal data from the China Health and Nutrition Survey (CHNS) collected in 2009, 2015, and 2018. A total of 8,023 participants aged ≥40 years (3,595 males and 4,428 females) were included. The Generalized Estimating Equation (GEE) method was employed to examine the association between inflammation, dyslipidemia, their combined effects, and stroke in the Chinese population.ResultsA total of 174 stroke events occurred during follow-up. Compared with those with normal CRP levels (CRP ≤ 3 mg/L), the adjusted ORs and 95%CI were 2.13 (1.25, 3.64) for the female with elevated CRP level. Compared with those with non-dyslipidemia, the adjusted ORs and 95%CI were 1.56 (1.03, 2.37) for the individuals with high LDL cholesterol, 1.93 (1.12, 3.33) for the male with high LDL cholesterol. Compared with those with normal CRP levels and non-dyslipidemia, the adjusted ORs and 95%CI were 1.74 (1.08, 2.78) for the individuals with elevated CRP levels and dyslipidemia, 2.41 (1.29, 4.49) for the male with elevated CRP levels and dyslipidemia. People with the coexistence of elevated CRP levels and dyslipidemia had the highest risk of stroke among male.ConclusionIn females, higher levels of inflammation are associated with an increased incidence of stroke. In males, individuals with dyslipidemia characterized by high LDL cholesterol levels are more susceptible to stroke. In the general population, the joint effect of inflammation and dyslipidemia predisposes individuals to a higher risk of stroke, particularly among males.
Solutions of Second-Order Nonlinear Implicit ψ-Conformable Fractional Integro-Differential Equations with Nonlocal Fractional Integral Boundary Conditions in Banach Algebra
Authors: Awad Yahia , Alkhezi Yousuf 
Published: August 2024

In this paper, we introduce and thoroughly examine new generalized ψ-conformable fractional integral and derivative operators associated with the auxiliary function ψ(t). We rigorously analyze and confirm the essential properties of these operators, including their semigroup behavior, linearity, boundedness, and specific symmetry characteristics, particularly their invariance under time reversal. These operators not only encompass the well-established Riemann–Liouville and Hadamard operators but also extend their applicability. Our primary focus is on addressing complex fractional boundary value problems, specifically second-order nonlinear implicit ψ-conformable fractional integro-differential equations with nonlocal fractional integral boundary conditions within Banach algebra. We assess the effectiveness of these operators in solving such problems and investigate the existence, uniqueness, and Ulam–Hyers stability of their solutions. A numerical example is presented to demonstrate the theoretical advancements and practical implications of our approach. Through this work, we aim to contribute to the development of fractional calculus methodologies and their applications.
ANALISIS POTENSI KECELAKAAN MENGGUNAKAN METODE HAZARD IDENTIFICATION AND RISK ASSESSMENT (HIRA) DAN JOB SAFETY ANALYSIS (JSA) PADA UMKM SOLEH
Authors: Adhe Avriyan  , Joko Susetyo  , Agus Hindarto Wibowo  
Published: August 2024

Usaha Kerupuk Pak Soleh adalah Usaha Kecil dan Menengah (UKM) yang bergerak di bidang produksi kerupuk. Terjadinya kecelakaan kerja di area produksi disebabkan kurangnya penerapan Keselamatan dan Kesehatan Kerja (K3) dan dapat menyebabkan dampak serius bagi pekerja, perusahaan dan lingkungan kerja. Tujuan penelitian ini adalah untuk meningkatkan keselamatan dan kesehatan kerja dengan mengidentifikasi bahaya dan risiko dalam proses produksi kerupuk serta menetapkan tindakan pengendalian yang tepat. Metode Hazard Identification and Risk Assessment (HIRA) digunakan untuk mengidentifikasi sumber masalah potensial terkait bahaya dan risiko selama proses produksi kerupuk, dan metode Job Safety Analysis (JSA) digunakan untuk menganalisis risiko yang terkait dengan tugas-tugas khusus dalam produksi kerupuk. Berdasarkan hasil identifikasi bahaya, terdapat tiga risiko atau bahaya yang memiliki nilai resiko tinggi, masing-masing bahaya dinilai berdasarkan terjadinya kecelakaan dan tingkat keparahan cedera atau kerusakan. Pertama yaitu proses penggorengan kerupuk nilai resiko sebesar 34, proses penggorengan masih menggunakan alat manual menggunakan kayu bakar. Kedua aktivitas gudang memiliki nilai resiko sebesar 15, pengambilan bahan baku dari gudang. Ketiga yaitu aktivitas pembuatan adonan memiliki nilai resiko sebesar 10. Tindakan pengendalian diusulkan untuk mengurangi atau menghilangkan risiko, seperti penggunaan alat pelindung diri (APD), pelatihan keselamatan. Selama analisis menggunakan JSA, bahaya yang terkait dengan masing-masing tugas diidentifikasi, dan risiko dievaluasi. Hasil penelitian ini diharapkan dapat memberikan wawasan yang lebih baik tentang potensi kecelakaan dalam proses produksi kerupuk. Dari hasil identifikasi bahaya dan risiko serta menerapkan tindakan pengendalian yang tepat, diharapkan tingkat kecelakaan dan cedera dapat dikurangi secara signifikan
Kajian Literatur: Kemampuan Literasi Sains dalam Pembelajaran IPA
Authors: Zubair Sakinah , Yanto Nurfitra 
Published: August 2024

The science literacy ability of students in Indonesia is still far below the international average score. Several things that can cause this include the applicable education system, choice of models, approaches, methods, strategies, and learning methonds, choice of learning resources, student learning styles and learning infrastructure. The research method used is a literature study that examines students science literacy skills in science learning. A total of 16 articles with the theme of science literacy were collected, analyzed, and cocluded to obtain recommendations about students science literacy skills in science learning. The results of the literature review obtained several things, namely: (1) the literacy ability of students is still relatively low and one of the causes is the low science literacy ability of science educators. (2) learning models that can improve students’ science literacy skills are applying appropriate learning models including problem based learning, inquiry, ethnoscience, RQA, Discovery Model Assisted By PhET Simulation. (3) types of teaching materials that can improve students science literacy skills are guided inquiry-based teaching materials, STEM-based teaching materials, and interactive multimedia in a blended learning manner.
Dukungan Keluarga dan Efikasi Diri Mempengaruhi Hasil Belajar Biologi Peserta Didik Kelas XI SMA Negeri 24 Bone
Authors: Hasmatang Hasmatang , Rahmat Irwandi 
Published: August 2024

Penelitian ini merupakan penelitian deskriptif yang bersifat korelasional dan bertujuan untuk mengetahui hubungan antara dukungan keluarga dan efikasi diri dengan hasil belajar biologi peserta didik. Populasi penelitian ini merupakan peserta didik kelas XI MIPA SMA Negeri 24 Bone sebanyak 94 orang. Sampel penelitian ini sebanyak 62 orang, diambil dengan teknik proporsional random sampling. Pengumpulan data dilaksanakan pada bulan Januari tahun ajaran 2019/2020. Data dukungan keluargan dan efikasi diri dikumpulkan menggunakan angket dan data hasil belajar biologi diperoleh dari tes hasil belajar biologi berupa soal pilihan ganda. Data penelitian dianalisis dengan statistik deskriptif untuk mengetahui dukungan keluarga, efikasi diri dan hasil belajar biologi peserta didik, serta statistik inferensial yaitu uji normalitas menggunakan Kolmogrov-Smirnov test, uji linieritas menggunakan analisis ANOVA Table, dan uji korelasi sederhana menggunakan Pearson Product Moment dan uji regresi untuk mengetahui hubungan dan kontribusi variabel dukungan keluarga dan efikasi diri dengan hasil belajar biologi peserta didik. Hasil penelitian menunjukkan bahwa: (1)dominan peserta didik memiliki dukungan keluarga kategori sedang dengan persentase 33,87%, (2)dominan peserta didik memiliki efikasi diri kategori sedang dengan persentase 35,48%, (3)dominan peserta didik memiliki hasil belajar biologi kategori sangat tinggi dengan persentase 35,48%, (4)terdapat hubungan positif dan signifikan antara dukungan keluarga dengan hasil belajar biologi peserta didik dengan kategori hubungan yang rendah, (5)terdapat hubungan positif dan signifikan antara efikasi diri dengan hasil belajar biologi peserta didik dengan kategori hubungan yang rendah, (6)terdapat hubungan positif dan signifikan antara dukungan keluarga dan efikasi diri secara bersama-sama dengan hasil belajar biologi peserta didik dengan kategori hubungan yang sedang.
Pelatihan Budidaya Tanaman Hidroponik dengan Pemanfaatan Limbah Botol Plastik Bagi Peserta Didik SMPN 4 Biringbulu Kabupaten Gowa
Authors: Kusumawati Ria , Handayani Dwi , Muliah Rezki , Muhiddin Nurhayani H , Yunus Sitti Rahma 
Published: August 2024

Menanam dengan sistem hidroponik menggunakan limbah botol plastik akan bermanfaat bagi lingkungan sekolah dan peserta didik. Dengan memanfaatkan limbah botol plastik dapat mengurangi sampah yang ada di sekolah dan peserta didik turut menjaga kelestarian lingkungan di sekolah. Tim KKN-T UNM desa Baturappe Kecamatan Biringbulu, Kabupaten Gowa melalui salah satu program kerjanya yaitu pelatihan budidaya tanaman hidroponik menjadi salah satu upaya menggerakkan peserta didik SMPN 4 Biringbulu dan memberikan motivasi kepada peserta didi SMPN 4 Biringbulu. Pelatihan ini dilaksanakan mulai pada tanggal 15 Oktober 2022 sampai tanggal 2 November 2022. Peserta didik melalui pelatihan budidaya tanaman hidroponik dapat berkreasi memanfaatkan limbah botol plastik untuk bertanam secara hidroponik sebagai bentuk partisipasi dalam mengembangan pertanian modern. Selain itu peserta didik mendapatkan pengetahuan dan keterampilan dalam desain produk, serta pemasaran yang dapat memberikan peluang wirausaha.
Determinan Penyerapan Tenaga Kerja Sektor Pertanian
Authors: Nahumury Marthen Ai , Mustofa Ali Ali 
Published: August 2024

ABSTRACT
This research aims to determine and analyze the agricultural sector's Gross Regional Domestic Product (GRDP), Farmer Exchange Rate (NTP), and Investment in labor absorption in Papua Province from 2010 to 2022. The type of data used is secondary data taken from 2010 to 2022.
Data was analyzed using quantitative methods, and the technique used was multiple linear regression analysis with the help of SPSS. 21. The influence of GRDP in the agricultural sector on labor absorption based on the analysis results shows that the hypothesis is accepted where t count > t table, the significant value < probability 0.05, and the coefficient value is -0.19. Thus, GRDP in the agricultural sector has a negative and significant effect on absorption labor, Farmer Exchange Rate based on the results of the analysis, it can be seen that the hypothesis is accepted, where t count>t table 8hthus the Farmer Exchange Rate has a negative and significant effect on sector labor absorption agriculture. Agricultural Sector Investment has a positive and insignificant impact, while the regression coefficient value is 0.010. This means that if investment in the agricultural sector increases by 1 percent, employment in the agricultural sector in Papua Province will increase by 0.010 or 1 percent. Simultaneously, GRDP in the agricultural sector, Farmer Exchange Rate (NTP), and Investment influence employment in the agricultural sector in Papua Province.

Keywords: Gross Regional Domestic Product (GRDP) in the agricultural sector, Farmer Exchange Rate (NTP), Investment and Labor Absorption.
Determinan Perilaku Keselamatan Kerja: Sebuah Analisis Empiris Perusahaan Pertambangan
Authors: Wonua Almansyah Rundu , Hendrik Hendrik , Yulianti Yulianti 
Published: August 2024

Keselamatan kerja karyawan merupkan salah satu isu penting dalam perusahaan pertambangan karena industri pertambangan merupakan salah satu industri yang memiliki risiko kerja yang tinggi. Karyawan yang bekerja di industri pertambangan selalu dihadapkan dengan berbagai bahaya dan resiko seperti kecelakaan kerja. Oleh karena itu, perusahaan pertambangan harus memperhatikan dan menjaga keselamatan kerja karyawan. Safety climate (Iklim keselamatan kerja) dan safety leadership (kepemimpian keselamatan) merupakan dua faktor penting dalam mendorong karyawan untuk melakukan perilaku aman di tempat kerja. Penelitian ini bertujuan untuk menganalisa pengaruh Safety climate dan safety leadership terhadap perilaku keselamatan kerja karyawan. Pendekatan yang digunakan adalan kuantitatif dengan metode survei dan analisis data menggunakan Structural Equation Modeling (SEM)-PLS dengan Smart PLS 3.0. Berdasarkan hasil penelitian menemukan bahwa iklim safety climate dan safety leadership sangat berpengaruh terhadap perilaku keselamatan kerja karyawan tambang. Hal ini mengindikasikan bahwa perusahaan harus memperhatikan iklim keselamatan kerja agar karyawan memiliki perilaku keselamatan kerja yang lebih baik. Kemudian Safety leadership yang baik dapat membantu meningkatkan kesadaran dan kesediaan karyawan untuk melaksanakan tindakan keselamatan kerja, serta memotivasi mereka untuk memprioritaskan keselamatan kerja dalam pekerjaan sehari-hari.