bluuebunny/crossref_metadata_2025_split huggingface dataset:
Baroreflex Sensitivity, Vascular Risk Factors, and Cognitive Function in a Healthy Elderly Population: The PROOF Cohort
Authors: Saint Martin Magali , Sforza Emilia , Thomas‐Anterion Catherine , Barthélémy Jean Claude , Roche Frédéric ,   The PROOF Study Group
Published: November 2013

ObjectivesTo assess the role of the cardiac autonomic nervous system (ANS), as measured according to spontaneous cardiac baroreflex sensitivity (BRS), in the type and degree of cognitive performance in healthy young‐elderly individuals, taking into account the presence of other vascular risk factors.DesignCommunity‐based cross‐sectional study.SettingIn‐home and clinical settings.ParticipantsA subset of participants, aged 66.9 ± 0.9, from a prospective study that aimed to assess the influence of ANS activity on cardiovascular and cerebrovascular morbidity and mortality (N = 916).MeasurementsAll subjects underwent a clinical interview, neuropsychological testing, and autonomic and vascular measurements. Three cognitive domains were defined: attentional (Trail‐Making Test Part A, Stroop code and parts I & II), executive (Trail‐Making Test Part B, Stroop part III, verbal fluency and similarity tests), and memory (Benton visual retention test, Grober and Buschké procedure). Subjects were stratified according to their scores into normal, low, and impaired performers.ResultsAfter adjustments to demographic and vascular data, participants with moderate autonomic dysregulation (3 < BRS ≤ 6) were determined to be 1.82 times as likely to have memory impairment (odds ratio (OR) = 1.82, 95% confidence interval (CI) = 1.13–3.17, P = .02) and those with severe autonomic dysregulation (BRS ≤ 3) to be 2.65 as likely (OR = 2.65, 95% CI = 1.40–5.59, P = .006) as participants with normal BRS (>6).ConclusionIn older individuals without dementia, autonomic dysregulation seems to have a direct, gradual, and independent effect on memory. Future studies are needed to evaluate the long‐term effects of BRS and other markers of the ANS on cognitive decline.
Clinical Outcomes of Cataract Surgery in Very Elderly Adults
Authors: Lai Frank H. P. , Lok Julie Y. C. , Chow Prudence P. C. , Young Alvin L. 
Published: November 2013

ObjectivesTo investigate the clinical outcomes of cataract surgery elderly adults.DesignRetrospective cohort study.SettingTwo clustered hospitals.ParticipantsTwo hundred seven individuals aged 90 and older who underwent cataract surgery for primary senile cataracts.MeasurementsBest‐corrected preoperative and postoperative Snellen visual acuity, type of cataract, surgical techniques, preoperative systemic or ocular comorbidities, and intraoperative and postoperative complications were assessed. Improvement of visual acuity was defined as a decrease in logMAR acuity of 0.1. Factors associated with visual outcome within 6 months after surgery were identified using logistic regression modeling. The duration of postoperative survival was calculated.ResultsIn the 207 participants (mean age 92.0 ± 2.1), 79.7% achieved visual improvement after cataract surgery. Forty‐eight percent (mean age 97.4 ± 2.8) were alive on December 31, 2012. The most common systemic comorbidities were hypertension (66.2%), diabetes mellitus (25.1%), and myocardial infarction (19.8%). Age‐related macular degeneration (AMRD) (15.9%), glaucoma (10.6%), and myopic degeneration (5.3%) were the three most common ocular comorbidities. Uncomplicated cataract surgery was performed in 87.0% cases. The most common complications were vitreous loss (8.2%), posterior capsular rupture (7.2%), and zonular rupture (4.8%). Participants with AMRD (P = .001, odds ratio (OR) = 4.77, 95% confidence interval (CI) = 1.86–12.26) and vitreous loss (P = .001, OR = 12.86, 95% CI = 2.71–61.10) were less likely to achieve postoperative visual improvement.ConclusionDespite a high prevalence of systemic and ocular comorbidities in very elderly adults, good clinical outcomes of cataract surgery were attainable. ARMD and vitreous loss were associated with a lower chance of postoperative visual improvement.
Family well‐being in a participant‐directed autism waiver program: the role of relational coordination
Authors: Warfield M. E. , Chiri G. , Leutz W. N. , Timberlake M. 
Published: November 2013

AbstractBackgroundMassachusetts is one of a very limited number of states exclusively employing participant‐direction to deliver autism waiver services to children. A crucial element of this waiver program is the work conducted by the state's Department of Developmental Services (DDS) staff and state‐approved providers with waiver families to facilitate the implementation of the participant‐direction model. Our study investigates the effect of the collaboration between state providers and family caregivers on family well‐being.MethodsWe conducted a survey of 74 families who have been utilising waiver services for at least 6 months. Participants were asked to rate the coordination with providers as well as to report on parenting stress and impact of waiver services on family functioning. Data from in‐home child and family assessments conducted by the state were also abstracted from program records.ResultsAfter controlling for a host of variables hypothesised to affect the outcomes of interest, we found that the family's view of how well they coordinated with formal providers is significantly associated all of the outcomes. Families who reported greater coordination with state providers experienced lower parenting stress and reported a more positive impact on family functioning. Child externalising behavioural problems and caregiver's health rating also contributed to parenting stress and family functioning.ConclusionsOur findings highlight the importance of establishing a collaborative partnership with waiver families in promoting family well‐being. These results suggest that training and/or resources that foster team building and communication can positively impact family functioning among families with young children with autism.
Anaphylactoid reaction after use of intracervical dinoprostone gel
Authors: Vaidya Madhuri , Ghike Sunita , Jain Sheela 
Published: November 2013

AbstractAnaphylactic‐like reaction or anaphylactoid reaction resembles generalized anaphylaxis but is not caused by immunoglobulin E‐mediated allergic reaction. This reaction is caused by a non‐immunologic mechanism even after first exposure to antigen. Prostaglandin E2 (dinoprostone) gel is commonly used for pre‐induction cervical ripening. We report a case of anaphylactiod reaction after insertion of prostaglandin E2 gel for induction of labor. Hyperstimulation with dinoprostone gel is reported in the literature. An isolated report of three cases of anaphylactiod reaction after intracervical dinoprostone gel was found during a literature search. We are reporting this case for its rarity. As a potentially life‐threatening condition, every obstetrician should be aware of this rare complication of dinoprostone gel.
Comparative analysis of laparoscopy versus laparotomy in the management of ovarian cyst during pregnancy
Authors: Chen Limei , Ding Jingxin , Hua Keqin 
Published: November 2013

AbstractAimThe aim of the present study was to evaluate the surgical and obstetric results of laparoscopy versus laparotomy in the management of ovarian cyst during pregnancy.Material and MethodsSixty‐nine eligible patients who met our criteria were randomly divided into the laparoscopy group (n = 33) and the laparotomy group (n = 36). The two groups were compared for their surgical and obstetric outcomes and the extent of pelvic adhesion discovered in later cesarean section (CS).ResultsThe laparoscopy group had less blood loss (43 ± 15 vs 51 ± 13 mL, P = 0.02), shorter postoperative hospital stay (2.9 ± 0.5 vs 5.8 ± 0.6 days, P < 0.001), and lower postoperative pain score (2.7 ± 1.2 vs 5.9 ± 1.5, P < 0.001) compared with the laparotomy group. The operative time, neonates' Apgar scores and birthweights between the two groups showed no significant differences (P > 0.05). Sixteen patients in the laparoscopy group, and 15 patients in the laparotomy group underwent cesarean section. The filmy and dense type adhesion rate was significantly different between the laparoscopy group and the laparotomy group (6.25% vs 53.3%, and 0% vs 20%, respectively).ConclusionsThe present results suggest that laparoscopy is a better choice than laparotomy for ovarian cyst during pregnancy, with less blood loss, less postoperative pain and less postoperative hospital stay. It offers a faster recovery, results in less pelvic adhesion and does not affect the fetus; however, studies encompassing larger numbers of cases are needed.
Bifid scrotum and anocutaneous fistula associated with a perineal lipomatous tumor complicated by temporary bilateral cryptorchidism in utero mimicking ambiguous genitalia: 2‐D/3‐D fetal ultrasonography
Authors: Inde Yusuke , Terada Yusuke , Ikegami Ei , Sekiguchi Atsuko , Nakai Akihito , Takeshita Toshiyuki 
Published: November 2013

AbstractAmbiguous genitalia (AG) is a morphological diagnosis defined as genitalia not typical of a male or female. Findings mimicking AG, such as penoscrotal anomalies, anorectal malformations, and perineal lipomatous tumors, may prevent accurate identification of the fetal sex. We report a case of bifid scrotum and anocutaneous fistula associated with a perineal lipomatous tumor complicated by temporary bilateral cryptorchidism in utero, which were findings mimicking AG. Several perineal anomalies are associated developmental occurrences. In the present case, the combination of bifid scrotum and temporary bilateral cryptorchidism in the male fetus mimicked the combination of clitoromegaly and prominent labia, which are commonly observed in female fetuses. However, serial systemic assessments using prenatal 2‐D/3‐D ultrasonography and magnetic resonance imaging were unable to detect the anocutaneous fistula and differentiate the perineal lipomatous tumor. This case report suggests that the prenatal detection of perineal abnormalities may warn obstetricians of potentially undetected congenital perineal anomalies.
Poor prognosis of ovarian cancer with large cell neuroendocrine carcinoma: Case report and review of published works
Authors: Asada Kayo , Kawana Kei , Teshima Shinichi , Saito Ako , Kawabata Masakiyo , Fujii Tomoyuki 
Published: November 2013

AbstractLarge cell neuroendocrine carcinoma (LCNEC) is well‐reported to result in unfavorable prognoses in many organ cancers while being rarely reported in gynecologic cancer, especially ovarian and endometrial cancers. Here we report a case of ovarian cancer with LCNEC which spread to distant organs within 1 year of primary surgery despite the fact that the post‐surgical stage was Ia. The case received platinum‐based chemotherapy as an adjuvant therapy after her curative surgery. However, LCNEC in the case was resistant to the chemotherapy. In our review of published works, ovarian cancer cases with LCNEC show poor prognoses regardless of adjuvant chemotherapy following complete resection. Median overall survival was 10 months in stage I cases. Development of chemotherapy sensitive for LCNEC is needed.
Does lactation protect mothers against metabolic syndrome? Findings from the Tehran Lipid and Glucose Study
Authors: Ramezani Tehrani Fahimeh , Momenan Amir Abbas , Bahri Khomami Mahnaz , Azizi Fereidoun 
Published: November 2013

AbstractAimWe aimed to explore the effect of lactation on development of metabolic syndrome in a prospective population‐based study.MethodsFrom among 4028 female participants of the Tehran Lipid and Glucose Study, aged 15–50 years, without metabolic syndrome at the initiation of the study, 925 women were randomly selected to fill out the lactation questionnaire. Women were assigned to five groups based on lactation duration including: none, 1–6 months, 7–12 months, 13–23 months and 24 months or more. Over a 9‐year follow‐up, metabolic syndrome was compared between these groups, before and after adjustment for possible confounding variables.ResultsMetabolic syndrome was developed in 12.1% of non‐lactating women; it was 28.6%, 34.0%, 26.2% and 26.7% in women with 1–6, 7–12, 13–23 and 24 months or more of lifetime duration of lactation, respectively (P < 0.002). Adjustment for confounders revealed that women with 1–6 and 7–12 months of duration of lactation had significantly higher odds of metabolic syndrome in comparison to 24 months or more (1.4 and 1.3 times, respectively).ConclusionIt seems that the longer duration of lactation up to 12 months may protect women against metabolic syndrome, in a dose–response manner.
Survival and prognostic factors of patients with primary fallopian tube cancer receiving adjuvant paclitaxel and carboplatin chemotherapy
Authors: Kietpeerakool Chumnan , Srisomboon Jatupol , Phongsaranantakul Supareuk , Khunamornpong Surapan , Cheewakriangkrai Chalong , Sribanditmongkol Narisa 
Published: November 2013

AbstractAimTo determine the survival and prognostic factors of patients with primary fallopian tube cancer (PFTC) who had been treated with paclitaxel and carboplatin chemotherapy.MethodsThe records of patients with PFTC who had been treated between 2002 and 2010, identified through the report of Chiang Mai University Hospital, were reviewed. All patients had pathological materials initially reported or reviewed by a gynecologic pathologist before initiation of treatment.ResultsThirty patients met the inclusion criteria. Median age was 51 years. Serous adenocarcinoma was observed in the majority of patients (76.7%). Approximately 46% of patients were in stage I–II. The 5‐year progression‐free survival (PFS) for all patients was 37.2%. The 5‐year PFS was 75.0% for stage I, 51.4% for stage II and 18.5% for stage III. Median PFS of the entire cohort was 26.0 months with a 95% confidence interval (CI) of 18.7–33.3 months. This rate was 18.5 months (95% CI, 6.7–35.6) for stage III whereas it was not reached for patients of stage I–II. Serous histology and stage were noted to be significant independent predictors of PFS with an adjusted hazards ratio of 7.54 (95% CI, 1.34–42.4) and 6.19 (95% CI, 1.59–24.08), respectively.ConclusionThe 5‐year PFS of the whole cohort was 37.2% with a median survival of 26 months. International Federation of Gynecology and Obstetrics stage and histological subtype were a significant independent factor for predicting PFS.
Consensus Recommendations for Immunosuppressive Treatment of Dogs with Glomerular Disease Based on Established Pathology
Authors:   IRIS Canine GN Study Group Established Pathology Subgroup, Segev G. , Cowgill L.D. , Heiene R. , Labato M.A. , Polzin D.J. 
Published: November 2013

The purpose of this report was to provide consensus recommendations for the use of immunosuppressive therapy in dogs with active glomerular diseases. Recommendations were developed based on comprehensive review of relevant literature on immunosuppressive therapy of glomerular disease in dogs and humans, contemporary expert opinion, and anecdotal experience in dogs with glomerular disease treated with immunosuppression. Recommendations were subsequently validated by a formal consensus methodology. The Study Group recommends empirical application of immunosuppressive therapy for dogs with severe, persistent, or progressive glomerular disease in which there is evidence of an active immune‐mediated pathogenesis on kidney biopsy and no identified contraindication to immunosuppressive therapy. The most compelling evidence supporting active immune‐mediated mechanisms includes electron‐dense deposits identified with transmission electron microscopic examination and unequivocal immunofluorescent staining in the glomeruli. For diseases associated with profound proteinuria, attendant hypoalbuminemia, nephrotic syndrome, or rapidly progressive azotemia, single drug or combination therapy consisting of rapidly acting immunosuppressive drugs is recommended. The Study Group recommends mycophenolate alone or in combination with prednisolone. To minimize the adverse effects, glucocorticoids should not be used as a sole treatment, and when used concurrently with mycophenolate, glucocorticoids should be tapered as quickly as possible. For stable or slowly progressive glomerular diseases, the Study Group recommends mycophenolate or chlorambucil alone or in combination with azathioprine on alternating days. Therapeutic effectiveness should be assessed serially by changes in proteinuria, renal function, and serum albumin concentration. In the absence of overt adverse effects, at least 8 weeks of the rapidly acting nonsteroidal drug therapy and 8–12 weeks of slowly acting drug therapy should be provided before altering or abandoning an immunosuppressive trial.
Regulation of toxin production in the pathogenic clostridia
Authors: Carter Glen P. , Cheung Jackie K. , Larcombe Sarah , Lyras Dena 
Published: November 2013

SummaryThe genus Clostridium comprises a large, heterogeneous group of obligate anaerobic, Gram‐positive spore forming bacilli. Members of this genus are ubiquitous in the environment and although most species are considered saprophytic, several are pathogenic to both humans and animals. These bacteria cause a variety of diseases including neuroparalysis, gas gangrene, necrotic enteritis, food poisoning, toxic shock syndrome and pseudomembraneous colitis, which in most cases arise as a consequence of the production of potent exotoxins. Treatment options are often limited, underscoring the need for new treatment strategies and novel therapeutics. Understanding the fundamental mechanisms and signals that control toxin production in the pathogenic clostridia may lead to the identification of novel therapeutic targets that can be exploited in the development of new antimicrobial agents.
Glomerular expression of myxovirus resistance protein 1 in human mesangial cells: Possible activation of innate immunity in the pathogenesis of lupus nephritis
Authors: Watanabe Shojiro , Imaizumi Tadaatsu , Tsuruga Kazushi , Aizawa Tomomi , Ito Tatsuya , Matsumiya Tomoh , Yoshida Hidemi , Joh Kensuke , Ito Etsuro , Tanaka Hiroshi 
Published: November 2013

AbstractSince viral infections activate type I interferon (IFN) pathways and cause subsequent release of IFN‐dependent proinflammatory chemokines and cytokines, the innate immune system plays an important role in the pathogenesis of lupus nephritis (LN). It has been reported that human myxovirus resistance protein 1 (Mx1), a type I IFN‐dependent transcript, acts against a wide range of RNA viruses. Although the expression of Mx1 in biopsy specimens obtained from patients with dermatomyositis and cutaneous lupus has been described, the expression of Mx1 in human mesangial cells (MCs) has remained largely unknown. We treated normal human MCs in culture with polyinosinic‐polycytidylic acid (poly IC), an authentic double‐stranded RNA, and analyzed the expression of Mx1 by reverse transcription‐polymerase chain reaction and western blotting. To elucidate the poly IC‐signalling pathway, we subjected the cells to RNA interference against IFN‐β. We also conducted an immunofluorescence study to examine mesangial Mx1 expression in biopsy specimens from patients with LN. Poly IC‐induced Mx1 expression in MCs are shown both time‐ and dose‐dependently, and RNA interference against IFN‐β inhibited poly IC‐induced Mx1 expression. Intense glomerular Mx1 expression was observed in biopsy specimens from patients with LN, whereas negative staining occurred in specimens from patients with IgA nephropathy or purpura nephritis. These preliminary observations support, at least in part, the theory of innate immune system activation in the pathogenesis of LN.
Clinical features and mutation of NPHP5 in two Chinese siblings with Senior‐Løken syndrome
Authors: Tong Huajuan , Yue Zhihui , Sun Liangzhong , Chen Huiqin , Wang Weiguang , Wang Haiyan 
Published: November 2013

Abstract:Senior‐Løken syndrome is a rare syndromic form of nephronophthisis that is associated with retinal dystrophy. Presently, seven genes (NPHP1‐6 and NPHP10) have been associated with Senior‐Løken syndrome. NPHP5 mutations are known to cause classical Senior‐Løken syndrome. Here, we report two sisters (II‐4, II‐5) from a Chinese Han ethnic family who presented with classical Senior‐Løken syndrome. Both affected sisters exhibited Leber's congenital amaurosis and juvenile nephronophthisis that progressed to end‐stage renal disease by the age of 16 years and 9 months in patient II‐4 and 12 years and 9 months in patient II‐5. Sequence analysis showed a homozygous truncated mutation in NPHP5, c.1090C>T (p.R364X), in the patient II‐4. This mutation is predicted to introduce a new open reading frame that results in the truncation of the C‐terminal 235 amino acids of nephrocystin‐5 and its consequent loss of function. Both parents carried a single heterozygous mutation in the same position, and no homozygous deletion of NPHP1 was found in this pedigree.
Valuing lively materialities: Bio‐economic assembling in the making of new meat futures
Authors: Henry Matthew , Roche Michael 
Published: November 2013

AbstractVariable profitability within New Zealand's red meat sector has again led to the problematisation of its constitutive relationships. This problematisation has almost inevitably focused on the structural transformation of the sector. Rather than beginning with structural transformation, we draw on assemblage theory to trace the assembling work associated with three unstable bio‐economic projects: Primera lamb, Wagyu beef and FarmIQ. The paper offers a cautionary assessment of experimentation and innovation in the red meat sector, and suggests that the search for an enduring structural solution will continually be disrupted by the lively materialities upon which the red meat sector relies.
Pediatric invasive streptococcal infection in northern and eastern regions of Hokkaido, Japan from 2010 to 2012
Authors: Sakata Hiroshi 
Published: November 2013

AbstractBackgroundThe frequency of occurrence of pediatric invasive streptococcal infection in Japan has not been studied, therefore the aim of this study was to survey the northern and eastern regions of Hokkaido from 2010 to 2012.MethodSurvey sheets were sent to the pediatric departments at 17 facilities where children in the subject region can be hospitalized. Responses were obtained from all of the 17 facilities.ResultsSeven patients developed group A streptococcal infection over the 3 years, and their ages ranged from 1 day after the birth to 15 years old. Sepsis was diagnosed in five children, and empyema and arthritis in the knee were found in one child each, respectively. The number of cases in children under 15 years old was six excluding the child who was 15 years old, and the incidence rate per 100 000 population was 1.00. Eight children developed group B streptococcal infection, and their ages ranged from 0 days to 2 months after birth. Two cases were the early onset type (age within 7 days) and six cases were the late onset type. Five children developed sepsis and three children developed meningitis. The frequency of occurrence was 0.24 per 1000 births; which was 0.06 per 1000 births for the early onset type and was 0.18 per 1000 births for the late onset type. No reports for group C or group G hemolytic streptococcal infection were obtained.ConclusionsThe incidence rates identified in the present survey are similar to those in other advanced countries, and appear to be valid.