bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development and Pilot Outcome Data of a Midlife Women's Health Assessment Clinic: A Comprehensive and Multidisciplinary Approach to Health Care
Authors: Deneris Angela , Wheeler Catherine , Salmon Shanna 
Published: May 2013

IntroductionAs women enter midlife, health issues and chronic health problems can emerge. The University of Utah Health Science Center's Midlife Women's Health Assessment Clinic was developed to provide a personalized approach to healthy aging by individual assessment, group education, motivational interviewing, and wellness coaching to women. This article describes the model of care and an initial evaluation of this model.MethodsFour pilot clinics were conducted to determine if the model would be successful. Data analyzed included patient history questionnaires, laboratory and diagnostic test results, new diagnoses, and follow‐up recommendations; telephone surveys of patients 2 to 4 weeks after clinic visits; and verbal queries of clinicians about their experiences and recommendations for improving the clinics.ResultsAmong the 62 women attending the clinics, the most frequent concern was healthy aging. Two‐thirds of the women had new diagnoses during the clinics. Both the women and clinicians participating positively evaluated the pilot clinics.DiscussionThis model of care could be replicated to provide comprehensive and efficient health care to aging women in a variety of settings.
Success rates of prosthetic restorations on endodontically treated teeth; a systematic review after 6 years
Authors: Ploumaki A. , Bilkhair A. , Tuna T. , Stampf S. , Strub J. R. 
Published: May 2013

SummaryThe aims of this systematic review were to investigate the success rates of prosthetic restorations on endodontically treated teeth and their manner of failure. PubMed and hand literature searches were conducted on studies published until June 2012. Only clinical studies on human subjects referring to the success rates of prosthetic restorations on endodontically treated teeth with a follow‐up period of at least 6 years were reviewed. A total of four studies were identified. Meta‐analysis showed the success rate to be 92% (CI 82–98%) for single crowns on endodontically treated teeth and 79% (72–86%) for fixed dental prostheses. Only one study reported on removable dental prostheses with a success rate of 66%. Single crowns on teeth restored without posts demonstrated a success rate of 94% (CI 84–99%), whereas where posts were placed, the success rate was lower (92% CI 82–98%). Single crowns over cast post‐and‐cores and prefabricated posts showed success rates of 93% (CI 82–99%) and 94% (CI 90–97%), respectively; both differences were not statistically significant (significance level of 5%). The most common reason for failure was post‐debonding. Single crowns seem to be the best treatment modality for endodontically treated teeth. However, due to the low number of studies included and their design, the results of this systematic review should be interpreted with caution. Further clinical studies are needed to provide high‐quality evidence on the topic.
Effects of Diagnostic Test Accuracy and Treatment Efficacy on the Occurrence of Suspected Failure of Heartworm Prophylaxis in Dogs
Authors: Rohrbach B.W. , Patton S. 
Published: May 2013

BackgroundFood and Drug Administration Center for Veterinary Medicine (FDA/CVM) cited concern regarding failure of heartworm prophylaxis. The positive and negative predictive value of the heartworm antigen test is an estimate of the probability of adult heartworm infection.Hypothesis/ObjectivesAssess the sensitivity, specificity, and predictive value of heartworm antigen tests. Explore the role of heartworm test accuracy and treatment with immiticide to generate reports of suspected failure of heartworm prophylaxis.MethodsLiterature searches for published information on the accuracy of heartworm antigen tests and efficacy of immiticide for treatment of the adult heartworm.ResultsWeighted averages for heartworm antigen test sensitivity and specificity were 78.2 and 97.3%, respectively. Efficacy of immiticide by 2‐injection or alternate dose protocols were 88.3 and 89.1%, respectively. Depending on prevalence, the positive predictive value of the heartworm antigen test ranged from 15 to 54% and negative predictive value from 99 to 99.9%. For a hospital testing 1,000 dogs per year, false‐positive test results may vary from 24 to 27 dogs. If these dogs were on heartworm preventive, they may undergo treatment and be classified as prophylaxis failures. Ten percent of dogs who were treated and continued or placed on prophylaxis at the time of treatment may have adult heartworms when tested 1 year later and be presumed to represent failure of prophylaxis.ConclusionsWhen interpreting heartworm antigen test results, clinical signs, history, and regional prevalence of heartworm disease should be considered in estimating the predictive value of the test result. Limitations of test and treatment should be discussed with clients as part of the decision‐making process.
Transvenous Retrieval of Foreign Objects Lost during Cardiac Device Implantation or Revision: A 10‐Year Experience
Authors: CALVAGNA GIUSEPPE M. , ROMEO PLACIDO , CERESA FABRIZIO , VALSECCHI SERGIO 
Published: May 2013

BackgroundMany techniques for the endovascular retrieval of lost or misplaced foreign objects have been developed, and the removal of almost every foreign object has become possible. In this paper, we report our experience in retrieving foreign objects lost during cardiac device implantations or previous extraction procedures.MethodsThis study was a retrospective analysis of the case records of all patients referred to our institution for transvenous retrieval of intravascular foreign objects.ResultsOver 10 years, 45 consecutive patients underwent procedures for the retrieval of intravascular foreign objects. These objects were: 25 distal portions of introducer sheaths, 18 pacing lead fragments, one guidewire, and one anchoring sleeve. The majority of fragments were located in the right ventricle and subclavian and caval veins. Some had migrated to the pulmonary artery or more distally. The median dwell time of the fragments was 3 months. Retrieval was most frequently achieved through the femoral veins, and was successful in 42 (93%) procedures. No procedure‐related complications occurred in this series.ConclusionsIn the present single‐center experience, the endovascular approach to retrieving intravascular objects lost during cardiac device implantation or previous extraction procedures seemed effective with currently available tools and was associated with no complications.
mHCN4 Genetically Modified Canine Mesenchymal Stem Cells Provide Biological Pacemaking Function in Complete Dogs with Atrioventricular Block
Authors: LU WEI , YAOMING NONG , BOLI RAN , JUN CHENG , CHANGHAI ZHANG , YANG ZHOU , ZHIYUAN SONG 
Published: May 2013

BackgroundThe study was undertaken to assess the properties of mouse HCN4 (mHCN4)‐modified canine mesenchymal stem cells (cMSCs) in dogs with experimentally induced complete atrioventricular (AV) block and electronic pacing.MethodsComplete AV block was induced in adult dogs who had undergone implantation of backup electronic pacemakers. cMSCs were transfected with mHCN4 genes. Evidence of successful IHCN4 expression was provided by patch‐clamp detection. mHCN4‐cMSCs or normal cMSCs were injected subepicardially into the left ventricular anterior wall of the dogs. Cardiac parameters were monitored for 6 weeks. Heart rate variability (HRV) was evaluated using quantitative Poincaré plots of R‐RN against R‐RN+1 intervals. cMSCs survival and expression of HCN4 in vivo were examined by histological studies and Western blot.ResultsIn 2 weeks, the maximum heart rate and the number of impulses generated from the injection sites were much higher in dogs injected with HCN4‐modified MSCs than in control dogs.  Basal heart rate increased in the HCN4 group and became fully stabilized by Week 4, evidenced by markedly reduced numbers of electronic pacemaker beats. At Week 2, HRV during exercise was significantly higher in HCN4 dogs than in controls as shown by descriptors of both instantaneous (SD1) and longer term (SD2) beat‐to‐beat deviations (P < 0.05). Hematoxylin‐eosin staining and Western blot proved that cMSCs survive and express HCN4 protein in situ in heart of HCN4 dog.ConclusionTransplantation of mHCN4‐modified cMSCs provided a stable biological pacemaking function that allowed an appropriate chronotropic response to physical exercise for up to 6 weeks.
Long‐Term Performance of Beat‐to‐Beat Automatic Ventricular Threshold Adjustment in Infants with Congenital Atrioventricular Block
Authors: HIIPPALA ANITA , HAPPONEN JUHA‐MATTI 
Published: May 2013

BackgroundAutoCapture™ (AC) of St. Jude Medical (SJM; St. Paul, MN, USA) pacemakers provides beat‐to‐beat ventricular capture verification and allows low‐amplitude pacing. There has been concern about evoked response signal (ERS) amplitude decreasing over time, leading to discontinuation of AC. The purpose of this study was to evaluate the long‐term performance of AC in infants with epicardial pacing leads.MethodsData on 16 newborns with congenital complete atrioventricular block (CCAVB) implanted with a SJM Microny pacemaker between January 1998 and December 2004 were collected. The ERS at discharge, at 12 ± 2 months, and long‐term AC performance were analyzed retrospectively. The median follow‐up time was 5.3 years (range 0.4–8.6 years), the end point of follow‐up being either lead or generator exchange.ResultsAC could be activated in all patients at discharge; the median ERS was 9.3 mV (3.7–19.0 mV). At 12 ± 2 months, the median ERS measured 4.6 ± 3.6 mV (n = 13), showing a significant decrease (P = 0.002) and leading to discontinuation of AC in three (23%) of 13 patients. AC use was possible in eight patients and long‐term use in six patients.ConclusionsIn epicardially paced CCAVB newborns, the ERS amplitude decreased significantly during the first year. ERS decrease was the most common reason for AC failure. At 1‐year follow‐up, AC was functional in only 53% of patients, although it could originally be activated in all patients. During the first year of follow‐up, special attention to AC parameters is recommended in this subgroup of pediatric pacemaker patients.
Objectively measured activity in 8–10‐year‐old Turkish children: Relationship to health‐related fitness
Authors: Güvenç Alpay , Aslan Alper , Açıkada Caner 
Published: May 2013

AbstractBackgroundNo objective data regarding the physical activity (PA) levels of young Turkish children currently exist. Furthermore, whether habitual PA is associated with the components of health‐related fitness among children is unclear. The aim of this study was to evaluate the patterns and levels of objectively measured PA in prepubertal Turkish children and its relationship with body fatness, aerobic and anaerobic fitness.MethodsEighty‐nine 8–10‐year‐old children (47 boys and 42 girls) participated in this study. The intensity, duration and frequency of PA were assessed from 4 days of heart rate monitoring with 15 s sampling intervals. Body fatness was determined by measuring skinfold thickness. Anaerobic fitness was evaluated using the Wingate test. All the children performed the shuttle run test to assess aerobic fitness.ResultsThe PA of boys was significantly higher than that of girls (P < 0.05). Gender difference is more marked for vigorous PA. Instead of sustained PA, short bouts of PA, lasting up to 1 min, were characteristic of PA patterns of children. The duration and frequency of PA were positively related to aerobic fitness and negatively related to fatness for both gender groups (P < 0.05). These relationships were more prominent for accumulated PA than for other measures of PA. No relationship was obtained between PA and anaerobic fitness in either gender group (P > 0.05).ConclusionsIntermittent, accumulated moderate intensity PA may be more important than sustained vigorous intensity PA in influencing children's fitness and fatness levels. Detailed studies are needed to clarify which dimension of PA is more beneficial for health‐related fitness in children.
High‐dose phenobarbital or erythropoietin for the treatment of perinatal asphyxia in term newborns
Authors: Avasiloaiei Andreea , Dimitriu Cristina , Moscalu Mihaela , Paduraru Luminita , Stamatin Maria 
Published: May 2013

AbstractBackgroundThe aim of this study was to compare two neuroprotective strategies to supportive care in the treatment of perinatal asphyxia.MethodsA total of 67 term newborns with perinatal asphyxia were included and randomized into three groups: one group received supportive treatment; another group received a single dose of 40 mg/kg phenobarbital; and the third received three daily doses of 1000 IU/kg erythropoietin. The following parameters were analyzed: gestational age, birthweight, Apgar scores, cord blood pH, total serum antioxidant status (TAS), superoxide dismutase (SOD), glutathione peroxidase (GPx) and malondialdehyde (MDA). The newborns were included in the follow‐up program and examined up to 18 months of age.ResultsTAS was higher in the erythropoietin group than in the other groups. SOD and GPx were lower for infants treated with phenobarbital or erythropoietin compared to control infants. MDA was lower in the erythropoietin group compared to the other groups, although the difference was not statistically significant (P > 0.05). The mortality rate was lower in the phenobarbital and erythropoietin groups (both 4.6%) than in the control group (17.4%). Long‐term neurologic follow up showed a high incidence of sequelae in the control group compared to the phenobarbital and erythropoietin groups. Follow‐up results were better in the phenobarbital group than in the erythropoietin group for motor and cognitive function at 3 and 6 months and worse for expressive language. At 18 months, however, the differences between these two groups were not significant.ConclusionHigh‐dose phenobarbital or erythropoietin along with supportive treatment has a positive influence on the outcome of newborns with perinatal asphyxia. Phenobarbital has the advantage of low cost and simplicity.
Feeding choice has a gender‐associated effect on infant growth
Authors: Nagahara Keiko , Dobashi Kazushige , Itabashi Kazuo 
Published: May 2013

AbstractBackgroundAppropriate nutrition during childhood is important for preventing future development of lifestyle‐related diseases. The effect of feeding choice on infant growth in Japan is not known.MethodsData from 204 healthy schoolchildren (age, 6–9 years) were obtained retrospectively from their parents by questionnaires. Breast‐fed (BF) and formula‐fed (FF) groups were defined as those fed only breast milk or formula milk at 4 months of age, respectively. There were 71 children (M/F, 31/40) in BF and 30 (M/F, 19/11) in FF. Anthropometric data at birth, and at 1, 4, 7, 10, 18, and 36 months of age in male and female infants were compared between the groups.ResultsIn male infants, height was significantly lower at 4 months, bodyweight was lower from 4 to 18 months, and body mass index (BMI) was lower from 10 to 36 months in BF than in FF. The standard deviation scores (SDS) for height, weight and BMI had a similar pattern. No significant differences were observed for these variables for female infants in BF compared with FF. Multiple regression analysis showed that birthweight, mother's pre‐pregnancy weight, and infant feeding choice were significant factors associated with weight‐SDS at 18 and 36 months. Feeding choice was the only factor associated with BMI‐SDS at 18 months.ConclusionsInfant feeding choice had a gender‐associated effect on growth during infancy. When evaluating infant growth, not only birthweight and mother's pre‐pregnancy weight, but also infant feeding choice and gender should be considered.
Intravitreal bevacizumab monotherapy for retinopathy of prematurity
Authors: Şahin Alparslan , Şahin Muhammed , Cingü Abdullah Kürşat , Çınar Yasin , Türkcü Fatih Mehmet , Yüksel Harun , Kaya Savaş , Arı Şeyhmus , Çaça İhsan 
Published: May 2013

AbstractBackgroundThe aim of this study was to evaluate the treatment outcomes of intravitreal bevacizumab (IVB) injections, used as a monotherapy in type 1 retinopathy of prematurity (ROP).MethodsA retrospective chart review was performed for 17 type 1 ROP patients (34 eyes), who had IVB injection between July 2011 and June 2012. Birthweight, gestational age at birth, stage and location of ROP, IVB injection time, time of complete retinal vascularization, and additional treatments if needed, were noted. A total of 0.625 mg (0.025 mL) bevacizumab was injected intravitreally.ResultsThirty eyes of 17 patients with type 1 ROP enrolled in the study were treated with IVB injection. Of them seven had aggressive posterior‐ROP, six had stage 2 ROP, and four had stage 3 ROP. The mean gestational age was 28.44 weeks (range, 26–31 weeks); and the mean birthweight was 1151.88 g (range, 600–1600 g). The mean age for IVB injection was 35.47 weeks. The mean full retinal vascularization time was 136.6 ± 26.6 days. The mean follow‐up time was 285.3 ± 70 days. ROP was regressed and retinal vascularization was completed in all cases except one eye, which had threshold disease.ConclusionIVB injection, used as a monotherapy, is an effective treatment approach in patients with type 1 ROP. Timely treatment of stage 2 and early stage 3 ROP in which disease progression was observed, prevents vitreoretinal membrane formation in posterior disease. Further studies need to be performed to determine the safety of IVB injection.
Dexibuprofen for fever in children with upper respiratory tract infection
Authors: Kim Chang‐Keun , Callaway Zak , Choung Ji Tae , Yu Jin Ho , Shim Kye Shik , Kwon Eun‐Mi , Koh Young Yull 
Published: May 2013

AbstractBackgroundThe aim of this study was to investigate the safety and efficacy of dexibuprofen compared to ibuprofen.MethodsThis double‐blind, double‐dummy study enrolled patients fromJanuary 2008 toMay 2009 presenting at one of five tertiary care centers inSeoul,Korea with febrile illness who were then given one of three active treatments: one dose of dexibuprofen 2.5 or 5 mg/kg (DEX 1); dexibuprofen 3.5 or 7 mg/kg (DEX 2); or ibuprofen 5 or 10 mg/kg (control) syrup. Those with a temperature <38.5°Cwere given the lower dose. Temperature was measured every hour for 4 h. Primary study outcome was mean change in temperature 4 h after one dose.ResultsA total of 264 children (aged 6 months–14 years) with febrile illness due to upper respiratory tract infection were consecutively sampled and screened, with 260 randomized. No patients withdrew due to adverse effects. Mean temperature change after 4 h (mean ±SD:DEX 1, 0.99 ± 0.84°C;DEX 2, 1.12 ± 0.92°C; control, 1.38 ± 0.84°C) differed only betweenDEX 1and controls (P= 0.007, 95% confidence interval [CI]: −0.61 to −0.15). When groups were subdivided according to initial temperature, there were no significant differences in mean temperature change after 4 h betweenDEX 2subgroups (<38.5°C, 0.88 ± 0.86°C; ≥38.5°C, 1.46 ± 0.90°C) and controls (1.07 ± 0.84°C and 1.72 ± 0.91°C, respectively), but there was a significant difference betweenDEX 1(≥38.5°C, 1.25 ± 0.76°C) and controls (P= 0.0222, 95%CI: −0.80 to −0.13). There were no significant differences in adverse events among groups.ConclusionDexibuprofen (3.5 or 7 mg/kg) is as effective and tolerable as ibuprofen for fever caused by upper respiratory tract infection in children.
Fighting Discrimination with Discrimination: Public Universities and the Rights of Dissenting Students
Authors: Affolter Jacob 
Published: May 2013

AbstractThis article discusses recent legal conflicts between state universities and conservative religious students in the United States, focusing on Christian Legal Society v. Martinez. In recent years, several universities have denied recognition to religious student organizations that discriminate on the basis of religion or sexual orientation. I argue that scholars on both sides of the issue have failed to recognize the full scope of the privilege that the universities demand. If the courts accept the universities' demands, then the courts dangerously expand the government's authority to suppress dissenters. No proponent of civil liberties should welcome this change.
Kant and Habermas on International Law
Authors: Mikalsen Kjartan Koch 
Published: May 2013

AbstractThe purpose of this article is to present a critical assessment of Jürgen Habermas' reformulation of Kant's philosophical project Toward Perpetual Peace. Special attention is paid to how well Habermas' proposed multi‐level institutional model fares in comparison with Kant's proposal—a league of states. I argue that Habermas' critique of the league fails in important respects, and that his proposal faces at least two problems. The first is that it implies a problematic asymmetry between powerful and less powerful states. The second is that it entails creating a global police force that has an obligation to intervene against egregious human rights violations worldwide, and that this seems incompatible with the idea that every person has an innate right to freedom. There are important normative constraints relevant for institutional design in the international domain that Habermas does not take sufficiently into account. However, this does not mean that Kant's league cannot be supplemented with more comprehensive forms of institutional cooperation between states. On the basis of my assessment of the multi‐level model, I propose a hybrid model combining elements from Kant and Habermas.
Novel role for cystic fibrosis transmembrane conductance regulator in alveolar fluid clearance in lipopolysaccharide‐induced acute lung injury in mice
Authors: Jin Weizhong , Song Yuanlin , Bai Chunxue , Jiang Jinjun 
Published: May 2013

AbstractBackground and objectiveAlveolar fluid clearance (AFC) is important for the resolution of acute lung injury (ALI). The role of cystic fibrosis transmembrane conductance regulator (CFTR) in AFC has not been entirely elucidated in animal models of ALI. The aim of this study was to investigate the role of CFTR and its mechanisms in AFC in normal and ALI mice.MethodsSeventy mice were randomly divided into 14 groups and ALI was established by intratracheal instillation of lipopolysaccharide (LPS). After 48 h, CFTR activator CFTRact‐16 or inhibitor CFinh‐172 with or without β‐agonist was instillated intratracheally and AFC was measured with radioisotopic tracer.ResultsAlthough there was no effects of CFTRact‐16 on AFC in mice with or without isoproterenol, CFinh‐172 markedly decreased isoproterenol‐stimulated AFC in both normal (P < 0.01) and LPS‐induced ALI mice (P < 0.01) and there was significantly decreased basal AFC in ALI mice (P < 0.05).ConclusionsThese results provide direct functional evidence for CFTR in cAMP‐mediated AFC in both normal and ALI mice.
Block‐threshold‐adapted Estimators via a Maxiset Approach
Authors: Autin Florent , Freyermuth Jean‐Marc , Von Sachs Rainer 
Published: May 2013

ABSTRACTWe study the maxiset performance of a large collection of block thresholding wavelet estimators, namely thehorizontal block thresholding family. We provide sufficient conditions on the choices of rates and threshold values to ensure that the involved adaptive estimators obtain large maxisets. Moreover, we prove that any estimator of such a family reconstructs the Besov balls with a near‐minimax optimal rate that can be faster than the one of any separable thresholding estimator. Then, we identify, in particular cases, the best estimator of such a family, that is, the one associated with the largest maxiset. As a particularity of this paper, we propose a refined approach that models method‐dependent threshold values. By a series of simulation studies, we confirm the good performance of the best estimator by comparing it with the other members of its family.