bluuebunny/crossref_metadata_2025_split huggingface dataset:
Testing the Preservation Activity of Ag‐TiO2‐Fe and TiO2 Composites Included in the Polyethylene during Orange Juice Storage
Authors: Peter Anca , Mihaly‐Cozmuta Leonard , Mihaly‐Cozmuta Anca , Nicula Camelia , Indrea Emil , Barbu‐Tudoran Lucian 
Published: July 2014

AbstractOrange juice was stored in polyethylene packages containing Ag‐TiO2‐Fe or TiO2 composites to establish the extent to which these composites influence the physical‐chemical, microbiological and organoleptic characteristics of the juice. The composites were characterized in terms of structure (X‐ray diffraction, transmission electron microscopy, Fourier‐transformed infrared) and photoactivity while the packages were profiled in terms of their UV‐vis absorption and water vapor permeability. The acidity and the browning rate of the sample stored in the package with Ag‐TiO2‐Fe decreased after 10 days of storage, as compared with the sample deposited in TiO2 packages and with the reference sample (polyethylene). The microbial population in the orange juice increased after 10 days of storage in all packages, but the increase was smaller in the Ag‐TiO2‐Fe polyethylene package. The organoleptic properties of the fresh orange juice deposited in package with Ag‐TiO2‐Fe were almost identical with those of the freshly prepared sample (0 days), whereas those of the juice deposited in the reference package were unacceptable.Practical ApplicationsThe study provides evidence that the packages of polyethylene modified with Ag‐TiO2‐Fe can be used to store fresh orange juice for 10 days at room temperature (22.5C).
Improving Medication Management Competency of Clinical Trainees in Geriatrics
Authors: Kostas Tia , Zimmerman Kristin , Salow Marci , Simone Mark , Whitmire Natalie , Rudolph James L. , McMahon Graham T. 
Published: July 2014

The authors hypothesized that an interprofessional workshop would improve geriatrics trainees' medication management. The workshop was based on a needs assessment and comprised an interactive session with pharmacists on managing medications in elderly adults. Participants were trainees in their geriatrics rotation at a tertiary care medical center. Trainees completed a medication appropriateness survey for three patients, one of which was their own. After the workshop, trainees reviewed medications of the three patients. Trainees completed online surveys after their rotation and 3 months later. Of 95 trainees rotating through geriatrics, 76 (80%) attended the workshop and completed the worksheet. Trainees' scores on reviewing medication lists improved significantly, from 6.7 ± 2.3 to 7.7 ± 2.0 out of 11 for standardized patient 1 (P < .001) and from 5.7 ± 1.8 to 6.4 ± 1.5 out of 11 for standardized patient 2 (P = .009). Trainees' scores on their own patients' lists also improved significantly, from 5.6 ± 1.5 to 6.6 ± 1.5 out of 10 (P < .001). After the workshop, 95% (71/75) planned to change the medication regimen of the patient they presented, and 93% (68/73) planned to change other patients' medications based on information learned during the workshop. Three months later, 35% (12/34) had made changes to the regimen of the patient they discussed during the workshop, and 71% (15/21) had made changes to other patients' regimens. Seventy‐eight percent (18/23) rated the workshop as the top nonclinical experience of their geriatrics rotation. In conclusion, this interprofessional medication management workshop improved trainees' ability to perform medication reviews accurately and led to change in self‐reported prescribing behavior.
Association Between Hearing Impairment and Lower Levels of Physical Activity in Older Adults
Authors: Gispen Fiona E. , Chen David S. , Genther Dane J. , Lin Frank R. 
Published: July 2014

ObjectivesTo determine whether hearing impairment, highly prevalent in older adults, is associated with activity levels.DesignCross‐sectional.SettingNational Health and Nutritional Examination Survey (2005–06).ParticipantsIndividuals aged 70 and older who completed audiometric testing and whose physical activity was assessed subjectively using questionnaires and objectively using body‐worn accelerometers (N = 706).MeasurementsHearing impairment was defined according to the speech‐frequency (0.5–4 kHz) pure‐tone average in the better‐hearing ear (normal <25.0 dB, mild 25.0–39.9 dB, moderate or greater ≥40 dB). Main outcome measures were self‐reported leisure time physical activity and accelerometer‐measured physical activity. Both were quantified using minutes of moderate‐intensity physical activity and categorized as inactive, insufficiently active, or sufficiently active. Ordinal logistic regression analyses were conducted and adjusted for demographic and cardiovascular risk factors.ResultsIndividuals with moderate or greater hearing impairment had greater odds than those with normal hearing of being in a lower category of physical activity as measured according to self‐report (OR = 1.59, 95% CI = 1.11–2.28) and accelerometry (OR = 1.70, 95% CI = 0.99–2.91). Mild hearing impairment was not associated with level of physical activity.ConclusionModerate or greater hearing impairment in older adults is associated with lower levels of physical activity independent of demographic and cardiovascular risk factors. Future research is needed to investigate the basis of this association and whether hearing rehabilitative interventions could affect physical activity in older adults.
Weight Change, Body Composition, and Risk of Mobility Disability and Mortality in Older Adults: A Population‐Based Cohort Study
Authors: Murphy Rachel A. , Patel Kushang V. , Kritchevsky Stephen B. , Houston Denise K. , Newman Anne B. , Koster Annemarie , Simonsick Eleanor M. , Tylvasky Frances A. , Cawthon Peggy M. , Harris Tamara B. ,   the Health, Aging, and Body Composition Study
Published: July 2014

ObjectivesTo examine associations between weight change, body composition, risk of mobility disability, and mortality in older adults.DesignProspective, longitudinal, population‐based cohort.SettingThe Health, Aging, and Body Composition Study.ParticipantsWomen (n = 1,044) and men (n = 931) aged 70 to 79.MeasurementsWeight and lean and fat mass from dual‐energy X‐ray absorptiometry measured annually over 5 years. Weight was defined as stable (n = 664, reference), loss (n = 662), gain (n = 321), or cycling (gain and loss, n = 328) using change of 5% from year to year or from Year 1 to 6. Mobility disability (two consecutive reports of difficulty walking one‐quarter mile or climbing 10 steps) and mortality were determined for 8 years after the weight change period. Associations were analyzed using Cox proportional hazards regression adjusted for covariates.ResultsDuring follow‐up, 313 women and 375 men developed mobility disability, and 322 women and 378 men died. There was no risk of mobility disability or mortality with weight gain. Weight loss (hazard ratio (HR) = 1.88, 95% confidence interval (CI) = 1.40–2.53) and weight cycling (HR = 1.59, 95% CI = 1.11–2.29) were associated with mobility disability in women, and weight loss was associated with mobility disability in men (HR = 1.30, 95% CI = 1.01–1.69). Weight loss and weight cycling were associated with mortality risk in women (weight loss: HR = 1.47, 95% CI = 1.07–2.01; weight cycling: HR = 1.62, 95% CI = 1.15–2.30) and in men (weight loss: HR = 1.41, 95% CI = 1.09–1.83; weight cycling: HR = 1.50, 95% CI = 1.08–2.08). Adjustment for lean and fat mass and change in lean and fat mass from Year 1 to 6 attenuated the relationships between weight loss and mobility disability in men and between weight loss and mortality in men and women.ConclusionWeight cycling and weight loss predict impending mobility disability and mortality in old age, underscoring the prognostic importance of weight history.
Barriers to Industrial Symbiosis: Insights from the Use of a Maturity Grid
Authors: Golev Artem , Corder Glen D. , Giurco Damien P. 
Published: July 2014

SummaryThe concept of industrial symbiosis (IS) over the last 20 years has become a well‐recognized approach for environmental improvements at the regional level. Many technical solutions for waste and by‐product material, water, and energy reuse between neighboring industries (so‐called synergies) have been discovered and applied in the IS examples from all over the world. However, the potential for uptake of new synergies in the regions is often limited by a range of nontechnical barriers. These barriers include environmental regulation, lack of cooperation and trust between industries in the area, economic barriers, and lack of information sharing. Although several approaches to help identify and overcome some of the nontechnical barriers were examined, no methodology was found that systematically assessed and tracked the barriers to guide the progress of IS development. This article presents a new tool—IS maturity grid—to tackle this issue in the regional IS studies. The tool helps monitor and assess the level of regional industrial collaboration and also indicates a potential path for further improvements and development in an industrial region, depending on where that region currently lies in the grid. The application of the developed tool to the Gladstone industrial region of Queensland, Australia, is presented in the article. It showed that Gladstone is at the third (active) stage of five stages of maturity, with cooperation and trust among industries the strongest characteristic and information barriers the characteristic for greatest improvement.
Sexuality of postinfarction patients: diagnosis, results and nursing intervention
Authors: Santos André Flávia dos , Maria Vera L Regina 
Published: July 2014

Aims and objectivesTo identify the main nursing diagnosis and to analyse and select the appropriate outcomes and interventions for postinfarction patients.BackgroundAfter a cardiac event, few patients resume their sexual life with the same intensity and frequency they used to have, and some patients do not even do it. Doubtful and insecure reactions are observed in both patients/partners and health professionals. These behaviours are frequently taboos and preconceptions about sexuality which are still taken as real among us.DesignExploratory study.MethodsIntegrative literature review with online search on the Virtual Health Library (BVS) and websites. The most relevant diagnosis in the general literature was compared with International Classification for Nursing Practice and North‐American International Nursing Diagnosis Association. The outcomes were selected from Nursing Outcome Classification, and the interventions and activities were based on the general literature and Nursing Intervention Classification.ResultsSexual dysfunction was the most relevant diagnosis described in the general literature. The characteristics and related factors were specified in patient's/their partner's verbalisation of the physical difficulties in having sexual activity and in their social and emotional reactions to the disease and to the prescribed medicine. The selected priority results were sexuality and knowledge on sexuality. The counselling intervention was chosen as the most appropriate.ConclusionIt was possible to get to the wide understanding of the sexual dysfunction as a nursing diagnosis expressed in the daily routine of the care to the postinfarction patient. Its identification requires knowledge and abilities to acknowledge its characteristics and related factors, which served as support for selection of outcomes, interventions and nursing activities.Relevance to clinical practiceAssociation between diagnosis, outcomes, interventions and nursing activities established for the postinfarction patient is strategic so as to guide the nurses who operate in the cardiovascular area and may contribute towards refinement of the nursing classifications.
Evaluating Callous‐Unemotional Traits as a Personality Construct
Authors: Frick Paul J. , Ray James V. 
Published: July 2014

AbstractWe evaluate the importance of callous‐unemotional (CU) traits as a personality construct in isolation from other facets of psychopathy. Specifically, we review research suggesting that these traits are useful for designating a subgroup of youth with serious conduct problems who differ from other antisocial youth on important biological, emotional, cognitive, and social characteristics. In addition, the temperamental features related to CU traits are risk factors for impairments in conscience development in young children. Thus, these traits could advance theoretical models explaining the development of severe antisocial behavior and psychopathy. CU traits also have important clinical utility because they designate a particularly severe and impaired subgroup of antisocial youth, leading to their inclusion in the DSM‐5. As a result of this inclusion in diagnostic classification, there has been an increased focus on how to best assess CU traits, and we discuss several key issues in their assessment, highlighting several limitations in existing measures. Finally, the increased use of CU traits, separately from other facets of psychopathy, makes it important to determine how these traits relate to other personality constructs. Thus, we examine how measures of CU traits relate to the broader construct of psychopathy and to other basic personality dimensions.
The effectiveness of quarter turn from prone in maintaining respiratory function in premature infants
Authors: Montgomery Karly , Choy Nancy L , Steele Michael , Hough Judith 
Published: July 2014

AimThe aim of this study was to determine the effectiveness of quarter turn from prone compared with supine and prone positioning in maintaining respiratory function in premature infants managed in a neonatal intensive care unit.MethodsThe study was a prospective, randomised, cross‐over trial with concealed allocation and intention to treat analysis. Fifty‐four infants ≤32 weeks gestation were randomly allocated to the order of the positions supine, prone and quarter turn from prone. Distribution of ventilation was assessed by measurement of regional impedance amplitude, global inhomogeneity index and phase angle analysis using electrical impedance tomography 30 min after each position change. Physiological characteristics of heart rate, respiratory rate (RR), oxygen saturation and inspired oxygen were also measured.ResultsThere was a significant difference between positions for RR with the RR in quarter turn from prone significantly lower than for supine (mean difference 6.53 breaths/min; 2.04–11.02), but not compared with the prone position. No significant differences between positions were found for any of the other outcomes measured.ConclusionThis study demonstrated that quarter turn from prone had an immediate positive positional effect on the RR of premature infants. The position of quarter turn from prone was comparable with prone in the maintenance of lung function and had a superior effect over supine on RR. These findings support the view that a quarter turn from prone can be confidently used in neonatal nurseries to manage premature infants.
Metered‐dose inhaler ipratropium bromide in moderate acute asthma in children: A single‐blinded randomised controlled trial
Authors: Wyatt Emma L , Borland Meredith L , Doyle Sarah K , Geelhoed Gary C 
Published: July 2014

AimTo determine if the addition of ipratropium bromide (IB) by metered‐dose inhaler in moderate acute asthma in children affects hospital admission rates when compared with inhaled salbutamol and oral prednisolone alone.MethodsA prospective, single‐blinded, randomised, controlled, equivalence trial in a tertiary paediatric emergency department. Patients aged 2–15 years with acute, moderate asthma were randomised to two groups, one receiving salbutamol, prednisolone and IB, the other receiving only salbutamol and prednisolone. The managing doctor was blinded to treatment. Admission rates were compared, and less than 15% difference was accepted as statistically equivalent.ResultsRecruitment ran from June 2007 until January 2011. Three hundred forty‐seven subjects were analysed. The admission rate in the IB group was 70.1% (122/174) compared with 64.2% (111/173) in the non‐IB group. The absolute difference of +5.9% (95% confidence interval −4.0% to 15.8%) is not statistically equivalent but does not show a statistically significant decrease in admission rates when IB was given. Adverse effects were more prevalent in the IB group, at 13.2% (23/174), compared with 4.6% (8/173) in the non‐IB group, a relative risk of 2.86 (95% confidence interval 1.31–6.21).ConclusionIn children with acute asthma of moderate severity who are treated with adequate doses of salbutamol and prednisolone, the addition of IB is not significantly associated with a reduction in admission rates. There is a significantly higher rate of adverse effects if IB is given. IB should be reserved for children with severe asthma exacerbations.
First Detection of Root Rot and Foliar Blight on Pittosporum (Pittosporum tenuifolium) Caused by Pythium irregulare in Italy
Authors: Guarnaccia Vladimiro , Hansen Zachariah R. , Aiello Dalia , Smart Christine D. , Polizzi Giancarlo 
Published: July 2014

AbstractDuring 2013, a new root rot and leaf blight was detected on potted Pittosporum tenuifolium cv. ‘Silver Queen’ plants in a nursery located in the Catania province (eastern Sicily, Italy). On the basis of morphological and cultural features as well as internal transcribed spacer sequence data, the causal agent was identified as Pythium irregulare. Koch's postulates were fulfilled by pathogenicity tests carried out on potted P. tenuifolium cv. ‘Silver Queen’ plants. To our knowledge, this is the first detection of P. irregulare root rot and foliar blight disease on P. tenuifolium in Europe, and it is the first detection using molecular methods for this oomycete pathogen in Italy.
Increased aqueous solubility and proapoptotic activity of potassium koetjapate against human colorectal cancer cells
Authors: Jafari Seyedeh Fatemeh , Khadeer Ahamed Mohamed B , Iqbal Muhammad Adnan , Al Suede Fouad Saleih R , Khalid Syed Haroon , Haque Rosenani A , Nassar Zeyad D , Umar Muhammad Ihtisham , Abdul Majid Amin Malik Shah 
Published: July 2014

Abstract

Objectives
Recently, we have isolated koetjapic acid (KA) from Sandoricum koetjape and identified its selective anticancer potentiality against colorectal carcinoma. KA is quite likely to be useful as a systemic anticancer agent against colorectal malignancy. However, with extremely low solubility, KA has to be converted into a biocompatible solubilized form without compromising the bioefficacy. Objective of this study is to enhance solubility of KA and to evaluate anticancer efficacy of potassium koetjapate in human colorectal cancer cells.

Methods
(2-Hydroxypropyl)-β-cyclodextrin inclusion complex and solid dispersions (carboxymethyl cellulose, polyvinylpyrrolidone and sodium lauryl sulphate) of KA were prepared. In addition, a salt of KA, potassium koetjapate was synthesized.

Key findings
Potassium koetjapate demonstrated higher solubility than the other tested formulations with enhanced cytotoxicity against HCT 116 cells. The enhanced efficacy of potassium koetjapate is attributed to apoptotic induction of nuclear condensation and disruption of mitochondrial membrane potential in the cells. Interestingly, potassium koetjapate was found to be safe in rats after oral administration (LD50 &gt; 2000 mg/kg).

Conclusions
The salt formulation of KA appears to modulate the capability of the parent compound by enhancing its solubility and improves its bioefficacy against colon cancer cells, suggesting attractive roles for its applications in medicine.
Integrating the R&D and Patent Functions: Implications for New Product Performance
Authors: Ernst Holger , Fischer Martin 
Published: July 2014

This paper examines the impact of cross‐functional integration between the research and development (R&D) and the patent functions on new product development (NPD) performance. The attitudinal (collaboration) and the behavioral (contributions of the patent function to NPD) dimension of cross‐functional integration between the R&D and the patent functions are distinguished. It is also investigated if the level of innovativeness moderates the relationship between the attitudinal and the behavioral dimension of cross‐functional integration between the R&D and the patent department and NPD performance.The four hypotheses are tested based on a multi‐informant sample of 101 NPD projects which are nested within 72 technology‐based firms or strategic business units from multiple industries in Germany.The results show that the attitudinal and the behavioral dimensions of cross‐functional integration between the R&D and the patent functions have a significant and positive impact on NPD performance. This lends empirical support for the notion expressed in the literature that certain managerial capabilities are important for understanding the effect of patenting on appropriability outcomes such as value creation and performance. The level of cross‐functional integration between the patent and the R&D functions appears to be one of these critical patent management capabilities that affect the returns from investments into patents.There is support for the hypothesis that the context matters for the effect of cross‐functional integration between the R&D and the patent functions on NPD performance. In line with the initial hypothesis, the level of innovativeness positively moderates the impact of the behavioral dimension of cross‐functional integration between the R&D and the patent department on NPD performance. In contrast to the initial hypothesis, the findings reveal no moderating effect of the level of innovativeness on the link between the attitudinal dimension of cross‐functional integration between the R&D and the patent department and NPD performance. This implies that joint objectives and an open and trustful working relationship between the R&D and the patent functions are not sufficient for achieving higher NPD performance if firms aim to develop very innovative products. In the case of highly innovative products, the actual behavior, that is, the specific contributions of the patent department to the NPD project, matters.Overall, these findings have important implications for improving performance by means of effectively integrating the patent and the R&D functions during NPD.