bluuebunny/crossref_metadata_2025_split huggingface dataset:
Induction mortality and resource utilization in children treated for acute myeloid leukemia at free‐standing pediatric hospitals in the United States
Authors: Kavcic Marko , Fisher Brian T. , Li Yimei , Seif Alix E. , Torp Kari , Walker Dana M. , Huang Yuan‐Shung , Lee Grace E. , Tasian Sarah K. , Vujkovic Marijana , Bagatell Rochelle , Aplenc Richard 
Published: February 2013

AbstractBACKGROUND:Clinical trials in pediatric acute myeloid leukemia (AML) determine induction regimen standards. However, these studies lack the data necessary to evaluate mortality trends over time and differences in resource utilization between induction regimens. Moreover, these trials likely underreport the clinical toxicities experienced by patients.METHODS:The Pediatric Health Information System database was used to identify children treated for presumed de novo AML between 1999 and 2010. Induction mortality, risk factors for induction mortality, and resource utilization by induction regimen were estimated using standard frequentist statistics, logistic regression, and Poisson regression, respectively.RESULTS:A total of 1686 patients were identified with an overall induction case fatality rate of 5.4% that decreased from 9.8% in 2003 to 2.1% in 2009 (P = .0023). The case fatality rate was 9.0% in the intensively timed DCTER (dexamethasone, cytarabine, thioguanine, etoposide, and rubidomycin [daunomycin]/idarubicin) induction and 3.8% for ADE (cytarabine, daunomycin, and etoposide) induction (adjusted odds ratio = 2.2, 95% confidence interval = 1.1‐4.5). Patients treated with intensively timed DCTER regimens had significantly greater antibiotic, red cell/platelet transfusion, analgesic, vasopressor, renal replacement therapy, and radiographic resource utilization than patients treated with ADE regimens. Resource utilization was substantially higher than reported in published pediatric AML clinical trials.CONCLUSIONS:Induction mortality for children with AML decreased significantly as ADE use increased. In addition to higher associated mortality, intensively timed DCTER regimens had a correspondingly higher use of health care resources. Using resource utilization data as a proxy for adverse events, adverse event rates reported on clinical trials substantially underestimated the clinical toxicities of all pediatric AML induction regimens. Cancer 2013. © 2013 American Cancer Society.
C18‐unsaturated branched‐chain fatty acid isomers: Characterization and physical properties
Authors: Ngo Helen L. , Dunn Robert O. , Hoh Eunha 
Published: February 2013

AbstractIso‐oleic acid is a mixture of C18‐unsaturated branched‐chain fatty acid isomers with a methyl group on various positions of the alkyl chain, which is the product of the skeletal isomerization reaction of oleic acid and is the intermediate used to make isostearic acid (C18‐saturated branched‐chain fatty acid isomers). Methyl iso‐oleate, a mixture of C18‐unsaturated branched‐chain fatty acid methyl ester isomers, is obtained via acid catalyzed esterification of iso‐oleic acid with methanol. The branched‐chain materials are liquid at room temperature and their “oiliness” property makes them an attractive candidate for the lubricant industry. In this paper, we report characterization of these branched‐chain materials using comprehensive two‐dimensional GC with time‐of‐flight mass spectrometry (GC × GC/TOF‐MS) and their physical and lubricity properties using tribology measurements.
Enantioselective Michael Addition of 4‐Hydroxycoumarins to β,γ‐Unsaturated α‐Oxophosphonates Catalysed by a Bifunctional Squaramide Bearing a Structurally Rigid 9,10‐Ethylene‐9,10‐dihydroanthracene Skeleton
Authors: Chang Xufang , Wang Qiaohui , Wang Youming , Song Haibin , Zhou Zhenghong , Tang Chuchi 
Published: February 2013

AbstractA bifunctional squaramide based on (R,R)‐11,12‐diamino‐9,10‐ethylene‐9,10‐dihydroanthracene has been developed, and it has demonstrated great advantages over previously reported organocatalysts in the asymmetric Michael addition of 4‐hydroxycoumarins to β,γ‐unsaturated α‐oxophosphonates. Upon quenching the generated β‐4‐hydroxy‐2‐oxo‐2H‐chromen‐3‐yl‐substituted acylphosphonate intermediates with DBU and an alcohol or amine as a second nucleophile, the corresponding β‐substituted carboxylates or amides were obtained in acceptable to excellent yields and with high levels of enantioselectivity (80–97 % ee) in a one‐pot fashion.
An Application of the Capability Maturity Model for Evaluating Attraction Websites in Mainland China
Authors: Zhong Lina , Leung Daniel , Law Rob , Wu Bihu , Shao Jun 
Published: February 2013

ABSTRACTThis paper extends the applicability of the Capability Maturity Model to attraction website evaluation. Based on input by 120 respondents from four groups, including tourists, tourism academics, attraction managers, and IT professionals in Mainland China, an attraction website maturity model (AWMM) with six key performance areas and 48 key criteria was developed. To validate the applicability of the model, the AWMM was used to evaluate 357 websites of 4A‐level attractions in Mainland China. Empirical findings revealed that the development of the China's attraction websites was at an infancy stage, while eCommerce in China has been adopted rapidly. Major improvements are required in relation to the interaction and commerce functions of these websites. Implications of the results of such improvements, as well as future research, are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Cure kinetics of epoxy resins by differential scanning calorimetry technique
Authors: Patel Ravji D. , Patel Ranjan G. , Patel Vithal S. 
Published: February 2013

AbstractThe curing reactions of epoxy resins with aliphatic amine are investigated using the differential scanning calorimetry technique with a single dynamic scan. The rate of the reaction was followed over the temperature range 30–250°C, and the activation energy and the order of the reaction are determined using four different computational methods. The activation energy for the various epoxy systems is observed in the range 40–76 kJ mol−1 and the order of the reaction is observed to be ⋍ 1·0.
Quantum mechanics approaches to drug research in the era of structural chemogenomics
Authors: Ilatovskiy Andrey V. , Abagyan Ruben , Kufareva Irina 
Published: February 2013

AbstractThe rapid growth of the available crystallographic information about proteins and binding pockets creates remarkable opportunities for enriching the drug research pipelines with computational prediction of novel protein–ligand interactions. While ab initio quantum mechanical (QM) approaches are known to provide unprecedented accuracy in structure‐based binding energy calculations, they are limited to only small systems of dozens of atoms. In the structural chemogenomics era, it is critical that new approaches are developed that enable application of QM methodologies to noncovalent interactions in systems as large as protein–ligand complexes and conformational ensembles. This perspective highlights recent advances towards bridging the gap between high‐accuracy and high‐volume computations in drug research. © 2013 Wiley Periodicals, Inc.
Compositional and structural characterization of alloyed carbide by 3D atom probe and high‐resolution TEM
Authors: Liu Qingdong , Zhao Shi‐Jin 
Published: February 2013

ABSTRACTDuring tempering of solute supersaturated ferrous martensite, the face‐centered cubic MC‐type carbides (M is alloy elements) such as VC and NbC phases usually co‐precipitate on crystal defects such as dislocation and take on plate‐like morphology. Over‐tempering makes the plate‐like shape change to spherical shape because ofOstwaldcoarsening. The coarsening process strongly correlates to the diffusion behaviors of the carbon and carbide‐forming elements, and consequently inhomogeneous compositional and structural distribution in the carbides is formed. Three‐dimensional atom probe and high‐resolution transmission electron microscopy have been proved useful methods to characterize the composition, morphology and nanostructure of the carbides that precipitate in a quench‐tempered micro‐alloyed steel. Depending on the actual affinity with C and the diffusion behavior, Si and Al are rejected from the alloy carbide, whereas Mn, V and Nb are inhomogeneously enriched in it. The morphology and structure change with the compositional redistribution. During the coarsening process of the pre‐existing plate‐like carbide, transition carbide that is semi‐coherent with ferritic matrix is formed because of the disparity in diffusion ratio of different solutes. A core–shell complex nanostructure is consequently formed in the coarsening carbide, and the core and shell are identified as V8C7enriched in Mn, Mo and Mo2C, respectively. Copyright © 2013 John Wiley & Sons, Ltd.
Synthesis and Crystal Structure of the Partially Oxidized Cyanoplatinates Rb1.75[Pt(CN)4]·1.25H2O and Cs1.75[Pt(CN)4]·0.5H2O
Authors: Mühle Claus , Nuss Jürgen , Jansen Martin 
Published: February 2013

AbstractCrystal structures of partially oxidized cyanoplatinates were determined by single crystal analysis. Rb1.75[Pt(CN)4]·1.25H2O crystallizes monoclinic in the space group P21/c [a = 1171.4(2) pm, b = 3315.3(6) pm, c = 1054.4(2) pm, β = 114.253(2)°, V = 3733.2(11)·106 pm3, Z = 16, Ntotal = 31567, R(F)N = 0.0858]. The compound was obtained by mixing aqueous solutions of Rb2[Pt(CN)4]·1.5H2O and Rb2[Pt(CN)4]Br2. Cs1.75[Pt(CN)4]·0.5H2O crystallizes in the space group Ibam [a = 1266.1(3) pm, b = 1347.5(3) pm, c = 580.4(1) pm, V = 990.2(3)·106 pm3, Z = 4, Ntotal = 5997, R(F)N = 0.0807]. Crystals of the latter were grown by slow electrochemical oxidation of Cs2[Pt(CN)4]·H2O in aqueous solution using platinum wires as electrodes. In both compounds platinum is partially oxidized to Pt+2.25 and the nearly square‐planar tetracyanoplatinate groups are arranged to columns in a staggered conformation. The rubidium compound features a large unit cell with nonlinear chains of platinum atoms and short alternating Pt–Pt distances of 292 and 294 pm, the cesium compound crystallizes more symmetrically with Pt–Pt distances of c/2 = 290 pm. The two compounds were also characterized by differential thermal analysis, thermogravimetry, infrared, and Raman spectroscopy.
Gallbladder bed resection or hepatectomy of segments 4a and 5 for pT2 gallbladder carcinoma: analysis of Japanese registration cases by the study group for biliary surgery of the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery
Authors: Horiguchi Akihiko , Miyakawa Shuichi , Ishihara Shin , Miyazaki Masaru , Ohtsuka Masayuki , Shimizu Hiroaki , Sano Keiji , Miura Fumihiko , Ohta Tetsuo , Kayahara Masato , Nagino Masato , Igami Tsuyoshi , Hirano Satoshi , Yamaue Hiroki , Tani Masaji , Yamamoto Masakazu , Ota Takehiro , Shimada Mitsuo , Morine Yuji , Kinoshita Hisafumi , Yasunaga Masafumi , Takada Tadahiro 
Published: February 2013

AbstractPurposeHepatectomy of segments 4a and 5 (S4a+5) is the recommended treatment for pT2 gallbladder cancer. However, gallbladder bed resection is also occasionally used. Using nationwide data from the Japanese Biliary Tract Cancer Registry and a questionnaire survey, we retrospectively compared these 2 methods of treatment.MethodThe study involved 85 patients with pT2, pN0 gallbladder cancer (55 treated with gallbladder bed resection, and 30, with S4a+5 hepatectomy). The prognosis and mode of tumor recurrence following treatment were analyzed retrospectively, with overall survival as the endpoint.ResultsThe 5‐year survival rate did not differ significantly between the 2 groups. Univariate analysis showed that bile duct resection and perineural tumor invasion were significant prognostic factors, but the extent of hepatectomy, location of the major intramural tumor, regional lymph node excision, and histological type were not. Multivariate analysis identified perineural tumor invasion as a significant prognostic factor. Recurrence occurred most frequently in both lobes than S4a+5 of the liver following gallbladder bed resection.ConclusionIn the present study of cases of Japanese Biliary Tract Cancer Registry, it was not possible to conclude that S4a+5 hepatectomy was superior to gallbladder bed resection.
Association between gallbladder stones and chronic hepatitis C: Ultrasonographic survey in a hepatitis C and B hyperendemic township in Taiwan
Authors: Dai Chia‐Yen , Lin Chia‐I , Yeh Ming‐Lun , Hsieh Meng‐Hsuan , Huang Chung‐Feng , Hou Nai‐Jen , Hsieh Ming‐Yen , Huang Jee‐Fu , Lin Zu‐Yau , Chen Shinn‐Cherng , Wang Liang‐Yen , Chang Wen‐Yu , Chen Jong‐Shyong , Yu Ming‐Lung , Chuang Wan‐Long 
Published: February 2013

AbstractGallbladder (GB) stones have been associated with several metabolic factors and liver diseases. This community‐based study aimed at investigating the prevalence rate of GB stones and its associated factors in a hepatitis B virus (HBV)/hepatitis C virus (HCV)‐endemic township in southern Taiwan. A total of 1701 residents (689 males and 1012 females; mean age: 51.2 ± 16.0 years) were enrolled in this prospectively designed screening project. Serum biochemistry tests, including testing for levels of serum aspartate aminotransferase, alanine aminotransferase (ALT), hepatitis B surface antigen (HBsAg), and antibody to HCV (anti‐HCV) were conducted. In addition, a hepatobiliary ultrasonographic (US) examination was also conducted. Of the 1701 residents, 243 (14.3%) and 475 (27.9%) were found to be positive for HBsAg and anti‐HCV, respectively. Results of the US examination revealed the prevalence rate of GB stone and fatty liver to be 6.8% and 55.6%, respectively. Using univariate analyses we found that significantly higher proportions of the participants with GB stone were male, over 50 years of age, positive for anti‐HCV (p = 0.001, p < 0.001, and p = 0.001, respectively), with significantly higher mean age and ALT level (p ≤ 0.001 and p = 0.048, respectively) than did those without GB stone. By applying multivariate analyses, male gender, positive anti‐HCV, and older age (>50 year) were identified as independent factors associated with the formation of GB stones. Anti‐HCV was associated with GB stones in males but not in females in both univariate and multivariate analyses. GB stones were found to have a prevalence rate of 6.8% in this HCV/HBV hyperendemic township and are associated with higher mean age. A correlation between chronic hepatitis C and GB stones is observed only among males.
Representation, Education and Agrarian Reform: Jogendranath Mandal and the nature of Scheduled Caste politics, 1937–1943
Authors: SEN DWAIPAYAN 
Published: February 2013

AbstractThis paper focusses on the Namasudra leader Jogendranath Mandal (1904–1968), and presents a study of the principal demands submitted by Scheduled Caste legislators over the course of the first half-decade of the Bengal legislative assembly. It seeks to understand these demands and why they were frustrated. It also traces and attempts to explain the withering away of Mandal's initial association with and favourable disposition towards the Congress. In contrast to accepted historiography, it argues that Scheduled Caste politics encompassed demands for representation, education and agrarian reform. It documents how their implementation (particularly the demand for representation) was compromised largely as a consequence of caste Hindu misrecognition.
Cinema-going in a port town, 1914–1951: film booking patterns at the Queens Cinema, Portsmouth
Authors: JAMES ROBERT 
Published: February 2013

ABSTRACT:This article examines the localized nature of leisure provision and consumer taste in Britain in the first half of the twentieth century. Based on an analysis of the cinema-going habits of naval personnel and dockyard workers and their families in the naval town of Portsmouth, this article reveals how closely consumers’ tastes were predicated on their social and cultural identities. By mapping film booking patterns at one cinema, this article reveals how cinema managers chose to book films which responded directly to the tastes of their patrons. The article concludes that the film preferences of this community were shaped by their close connections with naval life.
X-ray variability of 104 active galactic nuclei
Authors: González-Martín O. , Vaughan S. 
Published: February 2013

AbstractWe have performed a uniform analysis of the power spectrum densities (PSDs) of 104 nearby (z<0.4) active galactic nuclei (AGN) using 209 XMM-Newton/pn observations, including several AGN classes. These PSDs span ≃ 3 decades in temporal frequencies, ranging from minutes to days. We have fitted each PSD to two models: (1) a single power-law model and (2) a bending power-law model. A fraction of 72% show significant variability. The PSD of the majority of the variable AGN was well described by a simple power-law with a mean index of α = 2.01±0.01. In 15 sources we found that the bending power law model was preferred with a mean slope of α = 3.08±0.04 and a mean bend frequency of 〈νb〉 ≃ 2 × 10−4 Hz. Only KUG 1031+398 (RE J1034+396) shows evidence for quasi-periodic oscillations. The ‘fundamental plane’ relating variability timescale, black hole mass, and luminosity is demonstrated using the new X-ray timing results presented here together with a compilation of the previously detected timescales from the literature.
X-Ray Variability in LINERs
Authors: Hernández-García L. , González-Martín O. , Masegosa J. , Márquez I 
Published: February 2013

AbstractActive galactic nuclei (AGN) are powered by energetic phenomena which cannot be attributed to stars. LINERs appears to be the low power end of the AGN sequence with the lowest Eddington ratios but hosting the most massive black holes (typically 109M⊙). Whereas variability is common for high Eddington ratio emitting sources, in the low Eddington regime data are not so clear. Recent investigations at UV (Maozet al. 2005) and X-ray frequencies (Youneset al. 2011, González-Martínet al. 2011) point out to the long term variable nature for some particular LINERs.In this work we add more evidence about the X-ray variability in LINERs and investigate its nature. The data set comprises X-ray archival spectroscopy from observations taken fromChandraandXMM-Newton, selecting LINERs with several observations at different epochs. Up to now we analysed two LINER 1.9 objects, NGC 1052 and NGC 4278, and checked that variability is due to different mechanisms based on the results of spectral fittings.
Impact of accretion on the statistics of neutron star masses
Authors: Cheng Z. , Taani A. , Zhao Y. H. 
Published: February 2013

AbstractWe have collected the parameter of 38 neutron stars (NSs) in binary systems with spin periods and measured masses. By adopting the Boot-strap method, we reproduced the procedure of mass calculated for each system separately, to determine the truly mass distribution of the NS that obtained from observation. We also applied the Monte-Carlo simulation and introduce the characteristic spin period 20 ms, in order to distinguish between millisecond pulsars (MSPs) and less recycled pulsars. The mass distributions of MSPs and the less recycled pulsars could be fitted by a Gaussian function as 1.45±0.42 M⊙ and 1.31±0.17 M⊙ (with 1σ) respectively. As such, the MSP masses are heavier than those in less recycled systems by factor of ~ 0.13M⊙, since the accretion effect during the recycling process.
The gravitational wave signal from isolated objects
Authors: Liu Jinzhong , Zhang Yu 
Published: February 2013

AbstractAccording to the theoretical study, a deformation object (e.g., a spinning non-axisymmetric pulsar star) will radiate a gravitational wave (GW) signal during an accelaration motion process by LIGO science project. These types of disturbance sources with a large bump or dimple on the equator would survive and be identifiable as GW sources. In this work, we aim to provide a method for exploring GW radiation from isolated neutron stars (NSs) with deformation state using some observational results, which can be confirmed by the next LIGO project. Combination with the properties in observation results (e.g., PSR J1748-2446, PSR 1828-11 and Cygnus X-1), based on a binary population synthesis (BPS) approach we give a numerical GW radiation under the assumption that NS should have non-axisymmetric and give the results of energy spectrum. We find that the GW luminosity of LGW can be changed from about 1040 erg/s – 1055 erg/s.
Self-gravitational collapse of polytropic mass-losing gaseous discs: effects of outer boundary condition dictated by parent cloud
Authors: Nourbakhsh Erfan , Shadmehri Mohsen , Abbassi Shahram 
Published: February 2013

AbstractGiven the fact that accretion discs are associated with their parent molecular cloud, we studied its effects as a constraint on the outer boundary of the viscous-resistive polytropic self-gravitating accretion flows subject to the mass and angular momentum loss.
Analytical Modeling of Radial Velocity Curves of Hα Emission from WW And
Authors: Schwarz Casey , Montgomery Michele M. 
Published: February 2013

AbstractRadial Velocity (RV) plots of emission lines, including Hα, from non-magnetic Cataclysmic Variables (CV), are usually fit with a sin curve. This sin fit sometimes does not prove to be the best fit for some non-magnetic CVs with accretion discs. An analytical model is created based on our 3D Smoothed Particle Hydrodynamic (SPH) numerical code in order to simulate the RV curves. The observational target is WW And, a long period non-magnetic CV. The model takes into account disc ellipticity and inclination angle that provide good non-sinusoidal fits to the observed RV data.
MUSICIANS MAKE MARKETS
Authors: DeNora Tia 
Published: February 2013

ABSTRACT
Arts markets are not ‘neutral’. Rather, they are inevitably coloured by socio-cultural practices and regularities, some of which are embedded in and afforded by aesthetic forms and the values and images associated with these forms. The stabilisation of distribution and consumption patterns over time may thus be linked to, and structured by, often tacitly delineated meanings, values and practices associated with artistic products (musical works and their performance, in this case). These associations afford emotional attachments and identity-stances that may become integral to artistic distribution and in ways that are socially consequential. To the extent that distribution and consumption are inflected in these ways, markets may be understood to be culturally inflected. Market processes, in other words, can be seen as structures that are both shaped by, and shape, the flow and exchange of passion, emotion and often unremarked forms of sensibility. I explore these themes through a case study of the production and distribution of Beethoven's keyboard concertos in early nineteenth century Vienna. I describe how the distribution of Beethoven's works offered gendered ‘object lessons’ about music producer/distributers (composer/performers) and music consumers. Through these lessons, the market for high culture music came to be associated with exhibitions of physical prowess, a heroic mien, and, almost exclusively, performances by men.