bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of Acidity Degree (pH) on Thrombocyte Concentrate Products: Apheresis Method and Pooling Method
Authors: Ariani Resti , Kuspranoto Abdul H , Aulia Intan 
Published: August 2024

One indicator of the decreasing quality of thrombocyte concentrate (TC) during storage is the pH value. Thrombocyte making can use pooling and apheresis methods. The pooling method is carried out by combining 4-6 bags of single thrombocytes with sterile connecting device, while apheresis method is done automatically using apheresis machine. Quality Control Inspection of TC product is conducted to ensure the quality of the product in accordance with applicable specifications. This study aims to find out the difference in acidity degree value (pH) in thrombocyte concentrate apheresis and pooling methods. This type of research is descriptive comparative with the design of cross sectional section study. The population of research was all the results of pH value examination on thrombocyte apheresis and pooling in UDD PMI Semarang city in 2020, with the number of 48 bags each. The sampling technique used is total sampling. Analysis of research data was conducted univariate and bivariate with the help of SPSS version 25. The average pH value in thrombocyte apheresis 7,145 and in thrombocyte pooling 7,417. Bivariate analysis of thrombocyte apheresis and pooling using Independent Sample T-Test has a significance value of 0.000. From the results of the analysis of research data, there is a significant difference between the pH value in thrombocytes apheresis and pooling method. Because there are differences between the two pH values in thrombocyte products, there needs to be an improvement in the evaluation and monitoring of each product.
KORELASI KADAR PROTEIN URIN DENGAN UREUM DARAH PADA PASIEN GAGAL GINJAL KRONIK YANG MELAKUKAN HEMODIALISA DI RSHD. HARAPAN DAN DOA KOTA BENGKULU TAHUN 2023
Authors: Cynthia Dewi Devi 
Published: August 2024

Pendahuluan: Gagal ginjal kronik (GGK) merupakan suatu sindrom klinis yang disebabkan oleh penurunan fungsi ginjal yang bersifat menahun, bersifat progresif dan cukup lanjut. Apabila penyakit GGK seseorang telah mencapai stadium berat atau terminal maka terapi yang dapat meningkatkan harapan hidup penderita tersebut adalah hemodialisa. Dengan melakukan pemeriksaan protein urin dan ureum secara rutin, pasien akan mengetahui perkembangan fungsi ginjalnya. Sehingga tujuan penelitian ini adalah untuk mengetahui korelasi kadar protein urin dan ureum darah pada pasien GGK yang melakukan hemodialisa di RSHD Harapan Dan Doa Kota Bengkulu.
Tujuan : Untuk menganalisis apakah ada korelasi kadar protein urin dengan kadar ureum dalam darah pada pasien gagal ginjal kronik yang melakukan hemodialisa.
Metode Penelitian : Peneltian ini menggunakan survei analitik dengan desain penelitian cross sectional. Pengambilan sampel menggunakan teknik purposive sampling. Sampel dalam penelitian ini adalah 56 sampel pasien GGK yang melakukan HD. Penelitian ini dilakukan di Laboratorium RSHD Harapan Dan Doa Kota Bengkulu, pada tanggal 12 Juli sampai 25 Agustus 2023.
Hasil : uji statistik korelasi dan regresi dari 50 pasien GGK yang melakukan HD di RSUD Dr. M. Yunus Bengkulu yaitu korelasi (R =0,958) dan koefisein derterminasi (R2 =0,915) dengan nilai (pvalue =0,000 < 0,005). Yang artinya menunjukkan ada hubungan yang kuat antara kadar ureum darah dengan protein urin pada pasien GGK yang melakukan HD di RSHD Harapan Dan Doa Kota Bengkulu.
Kesimpulan : Terdapat Korelasi yang signifikan antara kadar protein urin dan ureum darah pada pasien gagal ginjal kronik yang melakukan hemodialisa di RSHD Harapan Dan Doa Kota Bengkulu Tahun 2023. Hal ini ditunjukan dari uji korelasi dan regresi dengan nilai (pvalue = 0,000 < 0,005)
Saran : Pasien yang menderita gagal ginjal kronik yang melakukan HD dapat melakukan pemeriksaan ureum darah dan protein urin secara rutin
Analysis of Language Errors in The Level of Phonology in The Movie Habibie and Ainun 3
Authors: Bukhari Ahmad Bukhari Nasution , Diva Azzurra Putri Rialni  , Nurul Hijrah  , Safinatul Hasanah Harahap  
Published: August 2024

This research aims to analyze phonological errors in the film Habibie and Ainun 3. The research method used in this research is a qualitative descriptive method. The qualitative descriptive method is fact-finding in the form of a systematic description of data and prioritizing the weight of data and research evidence, even though the research does not use calculations. The data collection technique is by watching films and recording the phonological errors spoken by the actors in the film. There are 20 phonological errors in the film Habibie and Ainun 3. These errors are found in the phonology area of ​​changing the pronunciation of phonemes with 11 errors, the area of ​​phoneme changes with 4 errors, the addition of phonemes with 2 errors, and the area of ​​changing diphthong sounds into single phonemes with 3 errors.

Keywords: film, Habibie and Ainun, phonology, linguistics
Autonomic dysfunction as a possible cause of sudden cardiac death in swimming sports
Authors: Dostal Jiri , Hybska Tereza , Saganelidze Khatuna , Pudil Radek , Stasek Josef 
Published: August 2024

IntroductionHuman diving reflex is a well-studied phenomenon. However, very little is known about the possible relationship between augmented diving reflex and autonomic dysfunction.MethodsWe retrospectively studied a group of four swimmers who underwent a diving reflex test as part of the examination due to symptoms related to autonomic dysfunction during swimming. The control group comprised 11 healthy swimmers with no history of these symptoms. A standardized diving reflex test was performed for each athlete in both groups. Hemodynamic profiles, including heart rate, stroke volume, and cardiac output, were recorded.ResultsThere were no statistically significant differences between the groups in any of the three parameters measured before the test. However, at the end of the test, each parameter (heart rate, stroke volume, and cardiac output) was significantly lower in the swimmers who presented with clinical symptoms related to autonomic dysfunction than in the control group.ConclusionThis observation could shed light on autonomic dysfunction as a possible cause of sudden cardiac death in swimming athletes. It also demonstrated that autonomic dysfunction is presented not only by decreased heart rate but also by stroke volume, causing a drop in cardiac output to the level of hemodynamic collapse.
Influence of gender and academic level on the development of digital competencies in university teachers: a multidisciplinary comparative analysis
Authors: Moreira-Choez Jenniffer Sobeida , Lamus de Rodríguez Tibisay Milene , Arias-Iturralde María Cristina , Vega-Intriago Jisson Oswaldo , Mendoza-Fernández Verónica Monserrate , Zambrano-Acosta Jimmy Manuel , Cardenas-Hinojosa Ruben Dario 
Published: August 2024

IntroductionIn the digital era, the evolving demands of professional fields, especially in higher education, have accentuated the need for advanced digital competencies among faculty members. Digital competencies are now considered essential for effective teaching, necessitating an in-depth understanding of how these skills are distributed across different demographics, including gender and academic level. This study aims to explore the digital competencies of faculty members at the State University of Milagro, focusing on how these competencies vary by gender and academic level.MethodsThis study employed a quantitative approach within the positivist paradigm to assess the digital competencies of 279 faculty members at the State University of Milagro. Data were collected using the Higher Education Digital Competence Assessment Questionnaire, a validated instrument designed to measure various dimensions of digital skills. Descriptive statistical analysis was conducted using SPSS to evaluate the internal consistency of the competencies and to identify correlations among them, as well as to assess the influence of gender and academic level on these competencies.ResultsThe analysis revealed significant correlations among the different dimensions of digital competencies, indicating that proficiency in one area often contributes to the development of skills in other areas. The integrative nature of digital technologies within the academic environment was evident, with a high level of internal consistency observed across the competencies assessed. Notably, differences were found based on gender and academic level, suggesting that these demographic factors influence technological exposure and training, with certain groups displaying higher competency levels in specific areas.DiscussionThe findings highlight the importance of promoting integrative educational strategies that consider the diverse backgrounds of faculty members to ensure equitable development of digital competencies. The observed gender and academic level disparities underline the need for targeted interventions that address the specific needs of different faculty groups. By fostering a more balanced development of digital skills, institutions can enhance overall teaching effectiveness and better prepare faculty to meet the demands of modern educational environments. These results contribute to the ongoing discourse on digital competency development in higher education and suggest avenues for further research on how to bridge existing gaps in digital skills among faculty.
Characteristics of children presenting with new onset diabetes and DKA in the COVID-19 pandemic: a national cohort study
Authors: Ponmani Caroline , Roland Damian , Lyttle Mark D. , Barrett Michael , Hulse Tony , Nijman Ruud G. 
Published: August 2024

ObjectivesThe objective of this study was to evaluate the characteristics of children presenting with new onset diabetes and diabetic ketoacidosis (DKA) in the first COVID pandemic year, compared to pre-pandemic evidence and identify the factors associated with DKA at diagnosis.DesignRetrospective medical record review.SettingForty-nine pediatric Emergency Departments (EDs) across the UK and Ireland.PatientsAll children aged 6 months to 16 years presenting to EDs with new onset diabetes and DKA, during the COVID-19 pandemic (1 March 2020–28 February 2021) and the preceding year (1 March 2019–28 February 2020).ResultsThere were increases in children presenting with new onset diabetes in DKA (395–566, 43%) and severe DKA (141–252, 79%) in the first COVID pandemic year, with patient characteristics similar to the pre-pandemic period. Healthcare seeking delay did not appear to be the sole contributing factor to DKA during the COVID pandemic. The median duration of symptoms of 14 days for both children who presented with and without DKA and were similar across both years; those in severe DKA had shorter median duration of 7 days (IQR: 5–21 days).ConclusionsThere were significant increases in children with new onset diabetes presenting with DKA in the first COVID pandemic year. Increased DKA rates and severity despite a constant median symptom duration suggest a multifactorial process. Studies to determine checkpoints for intervention between symptom onset and diagnosis of diabetes are vital to mitigate the high incidence of DKA in new onset diabetes.
Nomogram construction and evaluation for predicting non-remission after a single radioactive iodine therapy for Graves’ hyperthyroidism: a retrospective cohort study
Authors: Yu Feng , Ma Wenhui , Li Xue , Zhang Ruiguo , Kang Fei , Yang Weidong , Wang Renfei , Wang Jing 
Published: August 2024

BackgroundRadioactive iodine (RAI) therapy is a widely used treatment for Graves’ Hyperthyroidism (GH). However, various factors can impact the non-remission rate of GH after single RAI therapy. This study aimed to develop an online dynamic nomogram to assist physicians in providing personalized therapy for GH.MethodsData from 454 GH patients who received RAI therapy were retrospectively reviewed and included in the present study. The univariate and multivariate analysis were conducted to investigate and identify independent influencing factors. The nomogram was developed based on the training cohort to explore non-remission rates. Finally, the reliability and accuracy of the constructed nomogram model were verified in the validation cohort via the calibration, receiver operating characteristic (ROC) curve, and decision curve analysis (DCA).Results24-hours radioactive iodine uptake (RAIU24h), effective half-life (Teff), total iodine dose (TID) and iodine dose per gram of thyroid tissue (IDPG) were independent predictors. The nomogram had a high C-index 0.922 (95% CI: 0.892–0.953), for predicting non-remission. The calibration curves demonstrated excellent consistency between the predicted and the actual probability of non-remission. ROC analysis showed that the AUC of the nomogram model and the four independent factors in the training cohort were 0.922, 0.673, 0.760, 0.761, and 0.786, respectively. The optimal cutoff value for the total nomogram scores was determined to be 155. A total score of ≥155 indicates a higher likelihood of non-remission after a single RAI therapy for GH, whereas a score below 155 suggests a greater likelihood of remission. Additionally, the DCA curve indicated that this nomogram had good clinical utility in predicting non-remission.ConclusionAn online nomogram was constructed with good predictive performance, which can be used as a practical approach to predict and assist physicians in making personalized therapy decisions for GH patients.
Effectiveness of various interventions for non-traumatic osteonecrosis: a pairwise and network meta-analysis
Authors: Zhai Shaoyang , Wu Rui , Zhao Jie , Huang Wang , Hu Weiwei , Huang Weichen 
Published: August 2024

BackgroundOsteonecrosis of the femoral head (ONFH) is acknowledged as a prevalent, challenging orthopedic condition for patients.PurposeThis study aimed to evaluate the efficacy of various interventions for non-traumatic ONFH and provide guidance for clinical decision-makers.MethodsWe searched PubMed, Embase, Cochrane Library, and Web of Science databases from inception to February 2023 for relevant randomized controlled trials evaluating treatments for femoral head necrosis, without language restrictions. Quality evaluation was performed using the Cochrane risk-of-bias assessment tool, and analysis was performed using Stata 15.1.ResultsEleven randomized controlled trials were included in this study. The meta-analysis results revealed that CellTherapy [MD= -3.46, 95%CI= (-5.06, -1.85)], InjectableMed [MD= -3.68, 95%CI= (-6.11, -1.21)], ESWT [MD= -2.84, 95%CI= (-4.23, -1.45)], ESWT+InjectableMed [MD= -3.86, 95%CI= (-6.22, -1.53)] were significantly more effective in improving VAS pain score than CD+PTRI, as well as CD+BG+CellTherapy, and CD+BG. Furthermore, CD+BG+CellTherapy was better than CD+BG [MD= -0.97, 95%CI= (-1.71, -0.19)]. The SUCRA ranking for HHS score indicated that CellTherapy (77%) has the best effectiveness rate, followed by ESWT+InjectableMed (72.2%), ESWT (58.3%), InjectableMed (50%), CD+PTRI (31.4%), and CD+BG (11%). In terms of WOMAC and Lequesne scores, the meta-analysis showed no statistically significant differences between the experimental group CD+BG+CellTherapy and the control group CD+BG.ConclusionCellTherapy and non-surgical ESWT combined with medication or CellTherapy have the best effect on ONFH. Surgical CD+BG combined with CellTherapy is more effective than CD+BG alone. ESWT+InjectableMed is recommended for short-term or acute onset patients, while ESWT is recommended for long-term patients.Systematic review registrationhttps://www.crd.york.ac.uk/PROSPERO, identifier CRD42024540122.
AXL expression reflects tumor-immune cell dynamics impacting outcome in non-small cell lung cancer patients treated with immune checkpoint inhibitor monotherapy
Authors: Rayford Austin , Gärtner Fabian , Ramnefjell Maria P. , Lorens James B. , Micklem David R. , Aanerud Marianne , Engelsen Agnete S. T. 
Published: August 2024

IntroductionAXL receptor expression is proposed to confer immune-checkpoint inhibitor (ICI)-resistance in non-small cell lung cancer (NSCLC) patients. We sought to interrogate AXL expression in conjunction with mutational and tumor-microenvironmental features to uncover predictive mechanisms of resistance in ICI-treated NSCLC patients.MethodsTumor samples from 111 NSCLC patients treated with ICI-monotherapy were analyzed by immunohistochemistry for tumor- and immune-AXL expression. Subsets of patients were analyzed by whole-exome sequencing (n = 44) and imaging mass cytometry (n = 14). Results were related to ICI-outcome measurements.ResultsTumor-cell AXL expression correlated with aggressive phenotypic features including reduced OS in patients treated with ICIs (P = 0.04) after chemotherapy progression, but conversely associated with improved disease control (P = 0.045) in ICI-treated, PD-L1 high first-line patients. AXL+ immune-cell infiltration correlated with total immune-cell infiltration and improved overall outcomes (PFS: P = 0.044, OS: P = 0.054). Tumor-cell AXL-upregulation showed enrichment in mutations associated with PD-L1-upregulation and ICI-response such as MUC4 and ZNF469, as well as adverse mutations including CSMD1 and LRP1B which associated with an immune-suppressed tumor phenotype and poor ICI prognosis particularly within chemotherapy-treated patients. Tumor mutational burden had no effect on ICI-outcomes and was associated with a lack of tumor-infiltrating immune cells. Spatial-immunophenotyping provided evidence that tumor-cell AXL-upregulation and adverse mutations modulate the tumor microenvironment in favor of infiltrating, activated neutrophils over anti-tumor immune-subsets including CD4 and CD8 T-cells.ConclusionTumor-cell AXL-upregulation correlated with distinct oncotypes and microenvironmental immune-profiles that define chemotherapy-induced mechanisms of ICI-resistance, which suggests the combination of AXL inhibitors with current chemoimmunotherapy regimens can benefit NSCLC patients.
Correlation between the gut microbiota characteristics of hosts with severe acute pancreatitis and secondary intra-abdominal infection
Authors: Wang Lihui , Zhang Weijun , Dai Simin , Gao Yuan , Zhu Cheng , Yu Yuetian 
Published: August 2024

ObjectiveThe objective of the study is to investigate the changes in the composition of intestinal microecology in severe acute pancreatitis (SAP) patients with or without intra-abdominal infection and also to analyze the expression of antibiotic resistance genes to provide evidence for early warning of infectious diseases and the rational use of antibiotics.MethodsTwenty patients with SAP were enrolled in the study. According to whether the enrolled patients had a secondary intra-abdominal infection, they were divided into two groups, each consisting of 10 patients. Stool specimens were collected when the patients were admitted to the emergency intensive care unit (EICU), and nucleic acid extraction was performed. Next-generation gene sequencing was used to compare the differences in intestinal microflora diversity and drug resistance gene expression between the two groups.ResultsThe gut microbiota of patients in the infection group exhibited distribution on multiple clustered branches with some intra-group heterogeneity, and their flora diversity was compromised. The infected group showed an enrichment of various opportunistic bacteria in the gut microbiota, along with a high number of metabolic functions, stress functions to external signals, and genes associated with pathogenesis. Drug resistance genes were expressed in the gut microbiota of both groups, but their abundance was significantly lower in the non-infected group.ConclusionThe intestinal microbiota of patients in the infection group exhibited distribution on multiple clustered branches with some intra-group heterogeneity, and their flora diversity was compromised. Additionally, drug resistance genes were expressed in the gut microbiota of both groups, although their abundance was significantly lower in the non-infected group.
Genetically predicted the causal relationship between gut microbiota and the risk of polymyositis/dermatomyositis: a Mendelian randomization analysis
Authors: Niu Yanna , Zhang Yaochen , Fan Keyi , Hou Jialin , Liu Liu , Zhang Heyi , Geng Xinlei , Ma Xiyue , Lin Shilei , Guo Meilin , Li Xiaofeng , Zhang Shengxiao 
Published: August 2024

IntroductionObservational studies suggest associations between gut microbiota and polymyositis (PM) and dermatomyositis (DM), but causal relationships are unclear. We investigate the causal effects of gut microbiota on PM and DM, providing insights hoping to provide insights for future treatment and prevention.MethodsSummary statistics of gut microbiota were obtained from a multi-ethnic Genome Wide Association Studies (GWAS) meta-analysis, including 119 taxa from 18,340 Europeans. PM/DM statistics were extracted from GWAS analyses. Mendelian randomization (MR) with IVW, MR-Egger, and weighted median methods was performed. Sensitivity analyses addressed heterogeneity and pleiotropy. Of the 119 bacterial genera studied, six showed causal links.ResultsAlloprevotella (OR: 3.075, 95% CI: 1.127–8.386, p = 0.028), Ruminococcaceae UCG003 (OR: 4.219, 95% CI: 1.227–14.511, p = 0.022), Dialister (OR: 0.273, 95% CI: 0.077–0.974, p = 0.045) were associated with PM. Anaerotruncus (OR: 0.314, 95% CI: 0.112–0.882, p = 0.028), Ruminococcaceae UCG002 (OR: 2.439, 95% CI: 1.173–5.071, p = 0.017), Sutterella (OR: 3.392, 95% CI: 1.302–8.839, p = 0.012) were related to DM. Sensitivity analyses validated these associationsDiscussionWe establish causal relationships between Ruminococcaceae, Sutterella, Anaerotruncus with DM, Alloprevotella, Ruminococcaceae UCG003, and Dialister with PM. Common microbiota, like Ruminococcaceae, have significant clinical implications. These findings open up greater possibilities for the gut microbiota to contribute to the development of PM/DM and for future monitoring of the gut microbiota in patients with PM/DM.