bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of organisational resources and eligibility issues on transition from child and adolescent to adult mental health services
Authors: Belling Ruth , McLaren Susan , Paul Moli , Ford Tamsin , Kramer Tami , Weaver Tim , Hovish Kimberly , Islam Zoebia , White Sarah , Singh Swaran P 
Published: April 2014

Objectives To investigate the organisational factors that impede or facilitate transition of young people from child and adolescent (CAMHS) to adult mental health services (AMHS). Methods Thirty-four semi-structured interviews were conducted with health and social care professionals working in child and adult services in four English NHS Mental Health Trusts and voluntary organisations. Data were analysed thematically using a structured framework. Results Findings revealed a lack of clarity on service availability and the operation of different eligibility criteria between child and adult mental health services, with variable service provision for young people with attention deficit hyperactivity disorder, autism spectrum disorders and learning disabilities. High workloads and staff shortages were perceived to influence service thresholds and eligibility criteria. Conclusions A mutual lack of understanding of services and structures together with restrictive eligibility criteria exacerbated by perceived lack of resources can impact negatively on the transition between CAMHS and AMHS, disrupting continuity of care for young people.
A simple, safe and reliable surgical landmark for medial epicondylectomy
Authors: Smith Geoffrey CS , McCann Philip S , Clark Damian , Amirfeyz Rouin 
Published: April 2014

Background Various surgical strategies have been described for the treatment of cubital tunnel syndrome, including medial epicondylectomy. This aims to decompress the ulnar nerve and allow a ‘mini anterior transposition’. The major concern over medial epicondylectomy is the potential for postoperative iatrogenic valgus instability. Methods We utilized a surgical landmark for medial epicondylectomy based on the medial aspect of the ulnar nerve with the elbow in 90° of flexion in 12 cadaveric upper limbs. The size of the resultant fragment was measured and, subsequently, the medial collateral ligament was dissected and the elbow stressed to assess its integrity. Results This technique resulted in the excision of a fragment of mean width 8 mm (range 6 mm to 11 mm) and allowed the ulnar nerve to smoothly translate anteriorly in flexion. The anterior band of the ulnar collateral ligament was macroscopically preserved in all cases and there was no valgus instability. Conclusions The medial border of the ulnar nerve is a simple, safe and reliable surgical landmark for medial epicondylectomy. This technique offers advantages over other described methods of assessing the location at which to perform a medial epicondylectomy.
Current Concepts
Authors: Wolfstadt Jesse I. , Cole Brian J. , Ogilvie-Harris Darrell J. , Viswanathan Sowmya , Chahal Jaskarndip 
Published: April 2014

Context: The number of adults with osteoarthritis in the United States is expected to nearly double from 21.4 million in 2005 to 41.1 million by 2030. As a result, medical costs and associated comorbidity will exponentially increase in the coming decades. In the past decade, mesenchymal stem cells (MSCs) have emerged as a novel treatment for degenerative joint disease. Evidence Acquisition: PubMed (from 1990 to 2013) was searched to identify relevant studies. Reference lists of included studies were also reviewed. Study Design: Clinical review. Level of Evidence: Level 3. Results: We identified 9 animal and 7 human studies investigating the use of MSCs in the treatment of osteoarthritis, with varying levels of support for this therapy. Conclusion: While MSCs have shown potential for improving function and decreasing inflammation in animal studies, translation to patients is still in question. There is a great deal of heterogeneity in treatment methods. Standardizing the manufacturing and characterization of MSCs will allow for better comparisons.
Early detection of acute graft‐versus‐host disease by wireless capsule endoscopy and probe‐based confocal laser endomicroscopy: results of a pilot study
Authors: Coron Emmanuel , Laurent Valerie , Malard Florent , Le Rhun Marc , Chevallier Patrice , Guillaume Thierry , Mosnier Jean-François , Galmiche Jean-Paul , Mohty Mohamad 
Published: April 2014

ObjectiveAcute gastrointestinal graft‐versus‐host disease (GI‐GVHD) is usually diagnosed using endoscopic examinations and biopsies for conventional histology. The aim of this pilot study was to determine whether mini‐invasive techniques such as probe‐based confocal laser endomicroscopy (pCLE) combined with wireless capsule endoscopy (WCE) could detect early lesions of GI‐GVHD prior to symptoms.DesignFifteen patients undergoing allogeneic haematopoietic stem cell transplantation (allo‐HSCT) were prospectively examined with a small bowel WCE, duodenal and colorectal pCLE, and standard biopsies. Per study protocol, all these examinations were scheduled between day 21 and day 28 after allo‐HSCT, independently of the presence or absence of digestive symptoms.ResultsDuring follow up, eight patients developed acute GI‐GVHD. Sensitivity of WCE, pCLE, and histology were 50, 87.5, and 50%, respectively. Specificity of WCE, pCLE, and histology were 80, 71.5, and 80%, respectively. We showed a positive correlation between the Glücksberg scoring system and WCE (rho  = 0.543, p  = 0.036) and pCLE (rho  = 0.727, p  = 0.002) but not with standard histology (rho  = 0.481, p  = 0.069).ConclusionsThe results from this pilot study suggest that novel methods such as pCLE and WCE could be part of a mini‐invasive algorithm for early detection of GI‐GVHD.
STXBP1 promotes Weibel-Palade body exocytosis through its interaction with the Rab27A effector Slp4-a
Authors: van Breevoort Dorothee , Snijders Ambrosius P. , Hellen Nicola , Weckhuysen Sarah , van Hooren Kathinka W. E. M. , Eikenboom Jeroen , Valentijn Karine , Fernandez-Borja Mar , Ceulemans Berten , De Jonghe Peter , Voorberg Jan , Hannah Matthew , Carter Tom , Bierings Ruben 
Published: April 2014

Key PointsRecruitment of STXBP1 by Slp4-a promotes Weibel-Palade body exocytosis. Ex vivo EIEE4 endothelial cells haploinsufficient for STXBP1 have impaired Weibel-Palade body exocytosis.
Immunodeficiency scoring index to predict poor outcomes in hematopoietic cell transplant recipients with RSV infections
Authors: Shah Dimpy P. , Ghantoji Shashank S. , Ariza-Heredia Ella J. , Shah Jharna N. , El Taoum Katia K. , Shah Pankil K. , Nesher Lior , Hosing Chitra , Rondon Gabriela , Champlin Richard E. , Chemaly Roy F. 
Published: April 2014

Key Points
An immunodeficiency scoring index for RSV-infected hematopoietic cell transplant recipients predicts the risk of pneumonia and death. This scoring index would assist in the decision-making for initiating antiviral therapy in patients at high risk for poor outcomes.
Self-propelled Motor Driven by a Glucose Engine
Authors: Matsuda Yui , Yoshii Miyu , Suematsu Nobuhiko J , Izumi Shunsuke , Nakata Satoshi 
Published: April 2014

Abstract
We developed a catalytic propelled motor using the fuel source glucose, without the addition of hydrogen peroxide (H2O2), in an aqueous phase. The motor was composed of a Pt foil and a filter paper with glucose oxidase (GOx). H2O2 was produced by the enzyme reaction of GOx and glucose around the motor. The speed and fluctuation of the motor increased with an increase in the concentration of glucose based on the enzyme reaction.
The algorithm choice of the quantitative composition of the equipment technological systems
Authors: Акамсина  , Akamsina N. , Сербулов  , Serbulov Yuriy , Лемешкин  , Lemeshkin A. 
Published: April 2014

The paper realization of the process of selection and distribution of the &#34;discrete&#34; resources on the
example of the quantitative composition of the equipment and technological systems. Proposed models and
algorithms for solving the problem at the stages of synthesis system based on a modified method of normalizing functions.
Application of the Method for Generalised Estimation of the Public Health Factors (Review of Literature)
Authors: Титов  , Titov I. 
Published: April 2014

The paper presents the review of various methods for generalized estimation of the public health parameters, which are based on the principle of regulation of deviations from normative factors and are used in the management activities. The different algorithms for generalized evaluation of the health factors are given. The considered techniques suppose the choice of indicators on the basic directions of activity, tasks of the normative values of the selected indicators. This corresponds to the task of achieving the required values of the indicators in the reporting period, the calculation of current (achieved) health factors, the comparison of the current and normative factors of health on the one given in this paper the methods of calculation of the generalized evaluation and the level of achievement of result. The calculation is realized with provision for value chosen for calculation of the factors, including in the manner of functions. Methods of generalized evaluation of health factors can be used in the management activities of the health institutions and territorial public health, as well as on separate directions of their activity. By means of these techniques it is possible to evaluate the activities for improving health indicators. The advanced multivariate analysis based on generalized evaluation of health factors can be carried out, including on the basis of the algebraic models of constructive logic.
Der Fachinformationsdienst Musikwissenschaft und die neue Rolle der ViFaMusik
Authors: Diet Jürgen , Nägele Reiner 
Published: April 2014

ZusammenfassungDie Bayerische Staatsbibliothek betreut seit 1949 das Sondersammelgebiet Musikwissenschaft. Gemeinsam mit Repräsentanten der Fachcommunity wurde in einem Rundgespräch im März 2013 die künftige Serviceleistung im Fachinformationsdienst und die neue Rolle der ViFaMusik diskutiert. Die jahrzehntelange SSG-Erfahrung und die Ergebnisse des Rundgesprächs waren Grundlage des im Juni 2013 eingereichten FID-Antrags Musikwissenschaft.
Dezentral, offen, vernetzt – Überlegungen zum Aufbau eines LOD-basierten FID-Fachinformationssystems
Authors: Christoph Pascal , Pohl Adrian 
Published: April 2014

ZusammenfassungDieser Artikel reflektiert die „Richtlinien für das DFG geförderte System der Fachinformationsdienste für die Wissenschaft“ und zeigt auf, wie Linked Open Data (LOD) beim Umbau der Sondersammelgebiete (SSG) zu Fachinformationsdiensten (FID) helfen kann. Es wird dabei insbesondere auf den Aspekt (Meta-)Dateninfrastruktur eingegangen. Die These dieses Artikels ist, dass LOD prädestiniert ist, einen wichtigen Eckpfeiler einer nachhaltigen Metadateninfrastruktur für die Wissenschaft zu bilden.
Arbeit am Nächstmöglichen – Anreizsysteme für den künftigen FID Germanistik
Authors: Michel Volker 
Published: April 2014

ZusammenfassungVorgestellt werden innovative Ansätze, die seitens des SSG Germanistik unternommen wurden, um die Virtuelle Fachbibliothek Germanistik als eine zentrale Anlaufstelle für die Fachcommunity zu etablieren. Mit Blick auf die Umwandlung in einen FID wird die Fokussierung auf das traditionell an der UB Frankfurt gepflegte „bibliographische Kerngeschäft“ angeraten, das für alle Vertreter des Faches von großer Bedeutung ist, unabhängig von Status und Forschungsausrichtung.
Editorial: Fachportale für Bibliotheken
Authors: Depping Ralf 
Published: April 2014

ZusammenfassungVirtuelle Fachbibliotheken aus der Sicht der Förderpolitik der DFG innerhalb der letzten 15 Jahre: Es stellt sich die Frage, welchen Einfluss die DFG-Förderpolitik und das Dach-Projekt „vascoda“ auf die Entwicklung der Virtuellen Fachbibliotheken hatten. Darüber hinaus bleibt zu klären, welche Entwicklung die Virtuellen Fachbibliotheken im Kontext der Umwandlung der Sondersammelgebiete in Fachinformationsdienste für die Wissenschaft nehmen können. Das Editorial diskutiert die Rahmenbedingungen.
Hin zum Fachportal? Hin zur Kundschaft? Oder beides?
Authors: Pianos Tamara 
Published: April 2014

ZusammenfassungIm folgenden Beitrag werden die wichtigsten Services des Portals EconBiz sowie Gründe für einzelne Services und Überlegungen zur Umsetzung vorgestellt. Die Ausprägungen des Portals (Web, mobil etc.) sowie die Nutzung der Portalinhalte in unterschiedlichen Kontexten werden beschrieben. Neben der Darstellung der aktuellen Konsolidierungsarbeiten und der grundsätzlichen Frage zur Daseinsberechtigung von Fachportalen werden Fragen zu konkreten Zukunftsperspektiven von EconBiz diskutiert.
www.GEO-LEO.de – das Recherchewerkzeug des Fachinformationsdienstes für Wissenschaft zum System Erde und Weltall
Authors: Mühlhölzer Marianna , Pfurr Norbert , Porst Sven-S. , Wagenbreth Bernhard 
Published: April 2014

ZusammenfassungGEO-LEO ist ein zentrales Recherchewerkzeug zum System Erde und Weltall. Als integrierendes Internetportal dient es zum Nachweis gedruckter und elektronischer Informationsressourcen der Sondersammelgebietsbibliotheken in Freiberg und Göttingen sowie anderer fachrelevanter Anbieter. Zudem bietet es der Fachgemeinschaft eine Publikationsplattform für digitale Dokumente im Sinne des Open Access an. Das Portal, welches auf moderner Open Source Software basiert, stellt eine gute Basis für eine Webpräsenz eines zukünftigen astro-, geo- und montanwissenschaftlichen Fachinformationsdienstes für Deutschland dar.
The Crowd, the Cloud and Improving the Future of Medical Device Innovation
Authors: Huesch Marco , Szczerba Robert 
Published: April 2014

Abstract
Barriers and delays to medical device innovation are often solely attributable to the regulatory environment instead of both the current state of innovation practices and product development processes in the industry. Increasing the pace of innovation while reducing costs requires the creation of a new approach that fits both established medical device corporations as well as entrepreneurial start-ups. In this commentary we advance the concept of innovation platforms to facilitate ideation in the medical device space. Such platforms could also allow the full health benefits from individual medical devices to be reaped, by overcoming interoperability concerns through simulation and credentialing. Given the dramatic benefits of medical device success, such non-traditional business models for development may be potential solutions for industry, users and regulators.
Distribution of lignin in vascular bundles of coconut wood (Cocos nucifera) by cellular UV-spectroscopy and relationship between lignification and tensile strength in single vascular bundles
Authors: Fathi Leila , Frühwald Arno , Koch Gerald 
Published: April 2014

Abstract
The topochemical distribution of lignin in vascular bundles separated from different radial positions of Mexican coconut wood stems (Cocos nucifera) has been studied with focus on the relationship between the degree of lignification and tensile strength properties. The cellular lignin distribution was analyzed by UV-microspectrophotometry (UMSP) scanning at 280 nm of sections of vascular bundles (VBs) of 1 μm thickness. The fibers of the VBs with high tensile strength reveal a relatively low UV-absorbance at 280 nm (A280 nm 0.39), whereas the VBs with low tensile strength display the highest A280 nm (0.59). The S2 of fiber walls are characterized by the typical lamellar structure with increasing lignin contents from the cell lumen towards the compound middle lamellae (CML). The A280 nm data of CMLs are higher (0.67 to 0.87) than those of the S2 wall layers. Overall, the A280 nm values of S2 of fibers walls within single VBs of coconut are in the range of 0.36 to 0.59.
Determination of ion exchange constants for pairs of metal ions to lignocellulosic materials by column chromatography
Authors: Su Pingping , Granholm Kim , Harju Leo , Ivaska Ari 
Published: April 2014

Abstract
A method based on column chromatography has been developed for determination of ion exchange (IE) constants for pairs of metal ions for different types of wood, pulp, and bark samples. Bark was found to have higher selectivity than wood and pulp for the metal ions studied. Of the 14 different metal ions studied, the toxic transition metal ions Pb, Cu, and Cd were most strongly bound to all the materials used in this work. The validity of the column method was tested by means of different mixtures of metal ions as the loading solution. The IE constants obtained by the column method showed a good agreement with those obtained by the batch method reported earlier by our group. The IE constants were also determined for synthetic cation exchanger (CE) based on weak and strong acid groups. The IE constants of most pairs of metal ions are highest for the weakly acidic CE followed by bark, wood, pulp, and strongly acidic CE.
Effect of (4a) a novel 5-HT3 receptor antagonist on chronic unpredictable mild stress induced depressive-like behavior in mice: an approach using behavioral tests battery
Authors: Kurhe Yeshwant , Mahesh Radhakrishnan , Gupta Deepali , Thangaraj Devadoss 
Published: April 2014

Abstract

Background: The inconsistent therapeutic outcome necessitates designing and identifying novel therapeutic interventions for depression. Hence, the present study deals with the investigation of antidepressant-like effects of a novel 5-HT3 receptor antagonist (4-phenylpiperazin-1-yl) (quinoxalin-2-yl) methanone (4a) on chronic unpredictable mild stress (CUMS) induced behavioral and biochemical alterations.

Methods: Animals were subjected to different stressors for a period of 28 days. On day 15 after the subsequent stress procedure, mice were administered with (4a) (2 and 4 mg/kg p.o.), escitalopram (10 mg/kg p.o.), or vehicle (10 mL/kg p.o.) until day 28 along with the CUMS. Thereafter, behavioral battery tests like locomotor score, sucrose preference test, forced swim test (FST), tail suspension test (TST), and elevated plus maze (EPM) were performed. Biochemical assays like lipid peroxidation, nitrite levels, reduced glutathione (GSH), catalase, and superoxide dismutase (SOD) were estimated in the mice brain homogenate.

Results: (4a) Dose dependently attenuated the behavioral alterations by increasing the sucrose consumption, reducing the immobility time in FST and TST, increasing the open arm number of entries and time in EPM. Furthermore, biochemical alterations were reversed by (4a) as examined by reduced lipid peroxidation and nitrite levels and elevated antioxidant enzyme levels like GSH, catalase and SOD.

Conclusions: (4a) exhibits antidepressant potential by reversing the CUMS induced behavioral and biochemical changes in mice.
Clinical application of fetal left modified myocardial performance index in the evaluation of fetal growth restriction
Authors: Nassr Ahmed Abobakr , Youssef Alaaeldin Abdelhamid , Zakherah Mahmoud Sayed , Ismail Alaa Mahmoud , Brost Brian Charles 
Published: April 2014

Abstract

Objective: This study aims to evaluate cardiac function in fetuses with intrauterine growth restriction (IUGR) compared with healthy fetuses, using the left modified myocardial performance index (MPI) and the association between MPI and perinatal outcome.

Methods: Pregnant women between 34 and 39 weeks of gestation, who met the criteria for IUGR and were scheduled for delivery at an Egyptian tertiary medical center, were prospectively enrolled in the study. Women in the same gestational-age group with uncomplicated pregnancies were included as a control group. MPI was measured in all fetuses. The IUGR group was analyzed based on normal and abnormal umbilical artery (UA) Doppler. Perinatal outcomes were recorded.

Results: The mean left MPI was significantly higher in IUGR fetuses with abnormal UA Doppler (mean 0.58±SD 0.093) compared with healthy fetuses (mean 0.45±SD 0.070) (P<0.001). IUGR fetuses with abnormal left MPI showed significantly worse perinatal outcome and increased morbidity compared with the control group. IUGR fetuses with abnormal left MPI also showed significantly worse perinatal outcome compared with IUGR fetuses with normal MPI (whether the UA Doppler was normal or abnormal). The fetal MPI was associated with the severity of fetal compromise in IUGR fetuses based on the perinatal outcome.

Conclusion: MPI is a potentially useful tool in evaluating fetuses with suspected IUGR, which is crucial in classifying IUGR pregnancies into critical and non-critical cases and in predicting neonatal outcome.
Crystal structure of (E)-(2-((2,3-dihydrobenzo[b][1,4]dioxin-6-yl)methylene)- N-phenylhydrazinecarbothioamide, C16H15N3O2S
Authors: Chen Shi-Yao , Guo Feng-Min , Huang Yang-Ye , Ma Jian , Li Na , Sun Juan 
Published: April 2014

Abstract C16H15N3O2S, triclinic, P1¯ (no. 2), a = 5.2111(6) Å, b = 10.843(1) Å, c = 13.681(1) Å, α = 79.769(3)°, β = 86.485(3)°, γ = 86.080(4)°, V = 758.0 Å3, Z = 10, Rgt(F) = 0.0587, wRref(F2) = 0.1652, T = 273 K.
Crystal structure of catena[dichlorido-1,4-bis(2-methylbenzimidazol-1- ylmethyl)benzene-cadmium(II)]–N,N-dimethylformamide–water (2:2:1), [CdCl2(C24H22N4)]-C3N2O2H7-0.5H2O, C54H60Cd2Cl4N10O3
Authors: Xu Chun-Ying , Chu Wenjuan , Wang Shimin , Zhang Yalin 
Published: April 2014

Abstract C54H60Cd2Cl4N10O3, monoclinic, P21/c (no. 14), a = 9.552(2) Å, b = 26.647(5) Å, c = 11.094(2) Å, β = 98.23(3)°, V = 2794.7 Å3, Z = 2, Rgt(F) = 0.0485, wRref(F2) = 0.0968, T = 293 K.
Fine Mapping Reveals That Promotion Susceptibility Locus 1 (Psl1) Is a Compound Locus With Multiple Genes That Modify Susceptibility to Skin Tumor Development
Authors: Angel Joe M , Abel Erika L , Riggs Penny K , McClellan S Alex , DiGiovanni John 
Published: April 2014

Abstract
Although it is well known that the majority of human cancers occur as the result of exposure to environmental carcinogens, it is clear that not all individuals exposed to a specific environmental carcinogen have the same risk of developing cancer. Considerable evidence indicates that common allelic variants of low-penetrance, tumor susceptibility genes are responsible for this interindividual variation in risk. We previously reported a skin tumor promotion susceptibility locus, Psl1, which maps to the distal portion of chromosome 9, that modified skin tumor promotion susceptibility in the mouse. Furthermore, Psl1 was shown to consist of at least two subloci (i.e., Psl1.1 and Psl1.2) and that glutathione S-transferase alpha 4 (Gsta4), which maps to Psl1.2, is a skin tumor promotion susceptibility gene. Finally, variants of human GSTA4 were found to be associated with risk of nonmelanoma skin cancer. In the current study, a combination of nested and contiguous C57BL/6 congenic mouse strains, each inheriting a different portion of the Psl1 locus from DBA/2, were tested for susceptibility to skin tumor promotion with 12-O-tetradecanoylphorbol-13-acetate. These analyses indicate that Psl1 is a compound locus with at least six genes, including Gsta4, that modify skin tumor promotion susceptibility. More than 550 protein-coding genes map within the Psl1 locus. Fine mapping of the Psl1 locus, along with two-strain haplotype analysis, gene expression analysis, and the identification of genes with amino acid variants, has produced a list of fewer than 25 candidate skin tumor promotion susceptibility genes.