bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigating the Nootropic Effects of Shilajit on Hyoscine-Induced Zebrafish Model
Authors: Gupta Priyanka , Chatterjee Dhrita , Chatterjee Subhadas , Jash Rajiv 
Published: June 2024

Objective:
This study uses adult zebrafish as a model organism to explore the possible
cognitive-boosting properties of shilajit, a traditional Ayurvedic herbal resin. Shilajit is known
for its potential cognitive benefits, and the study focuses on its impact on memory and cognitive
function.

Methods:
The study employs a T-maze apparatus to assess cognitive performance in zebrafish,
particularly memory, and uses hyoscine, a memory-deficit-inducing compound, in the experiments. Various doses of shilajit (0.1, 0.2, 0.4, 0.8, 1.6 mg/ml) were administered to zebrafish via
water immersion, and lipid peroxidation and reduced glutathione were checked to measure oxidative stress.

Results:
The results reveal that shilajit positively affects memory in zebrafish with hyoscineinduced amnesia. Zebrafish treated with shilajit exhibited improved memory performance, as
indicated by increased entries into the reward arm (yellow) (p<0.05) and reduced latency time
(p<0.0001). Different doses of shilajit demonstrated varying effects, with higher doses leading
to more pronounced memory improvements. Furthermore, the study examined biochemical parameters in the zebrafish brains, with a specific focus on markers of oxidative stress. Shilajit
treatment was associated with a decrease in lipid peroxidation and an increase in reduced glutathione levels, signalling a reduction in oxidative stress (p<0.0001).

Discussion:
Finally, these findings suggest that shilajit not only alleviates memory deficits in
the zebrafish model but also possesses potential antioxidative properties in lowering reactive
oxygen species (ROS) levels in the brain.

Conclusion:
Our result suggests that shilajit counteracted the damage caused to cholinergic neurons in zebrafish brains by reducing ROS levels and improving learning and memory.
Acute myocardial infarction in patients with concomitant hypothyroidism: clinical features and heart rate variability during inpatient treatment
Authors: Gridneva Yu. Yu. , Chesnikova A. I. , Safronenko V. A. , Voronova A. V. 
Published: June 2024

Objective: to evaluate the features of the clinical course, as well as heart rate variability (HRV) during inpatient treatment in patients with ST-segment elevation myocardial infarction (STEMI) and concomitant newly diagnosed hypothyroidism.Materials and methods: the study included 133 patients with STEMI aged 40 to 88 years who were admitted to the cardiology department. Depending on the presence of newly diagnosed hypothyroidism syndrome, all patients were divided into 3 groups: group 1 consisted of patients with STEMI without hypothyroidism syndrome (n=57), group 2A — patients with STeMI and subclinical hypothyroidism (n=42) and group 2B — patients with STeMI and manifest hypothyroidism (n=34). Clinical symptoms and complications in the acute period of MI were evaluated in all patients, and Holter ECG monitoring (XM ECG) was performed.Results: during hospital treatment, patients with concomitant manifest hypothyroidism showed more frequent development of cardiac arrhythmias such as paroxysmal atrial fibrillation (AF) (p<0.05), supraventricular extrasystole (NE), paroxysmal supraventricular tachycardia (LVT) (p<0,05). When assessing the risk of early complications in the acute period of MI, higher scores were recorded in patients with manifest hypothyroidism (p<0.05). The analysis of HRV indicators showed that in the studied patients with concomitant manifest hypothyroidism, despite the presence of an acute period of MI, activation of the parasympathetic link of the ANS (autonomic nervous system) prevails in the regulation of heart rhythm, unlike in patients of the control group and the group with subclinical hypothyroidism, in whom, on the contrary, the influence of the sympathetic link of the ANS prevails.Conclusion: during hospitalization, patients with manifest hypothyroidism were statistically significantly more likely to develop supraventricular cardiac arrhythmias, and a higher risk of cardiovascular complications in the acute period of MI was determined compared with both the control group and the group of patients with subclinical hypothyroidism. In patients with concomitant manifest hypothyroidism, the activation of the parasympathetic link of the ANS in the regulation of heart rhythm is more pronounced, in contrast to patients in the control group and the group with subclinical hypothyroidism, in whom, on the contrary, the influence of the sympathetic link of the ANS prevails.
Perceptions of HIV-Related Comorbidities and Usability of a Virtual Environment for Cardiovascular Disease Prevention Education in Sexual Minority Men With HIV: Formative Phases of a Pilot Randomized Controlled Trial
Authors: Ramos S Raquel , Reynolds Harmony , Johnson Constance , Melkus Gail , Kershaw Trace , Thayer Julian F , Vorderstrasse Allison 
Published: June 2024

Background
Sexual minority men with HIV are at an increased risk of cardiovascular disease (CVD) and have been underrepresented in behavioral research and clinical trials.

Objective
This study aims to explore perceptions of HIV-related comorbidities and assess the interest in and usability of a virtual environment for CVD prevention education in Black and Latinx sexual minority men with HIV.

Methods
This is a 3-phase pilot behavioral randomized controlled trial. We report on formative phases 1 and 2 that informed virtual environment content and features using qualitative interviews, usability testing, and beta testing with a total of 25 individuals. In phase 1, a total of 15 participants completed interviews exploring HIV-related illnesses of concern that would be used to tailor the virtual environment. In phase 2, usability testing and beta testing were conducted with 10 participants to assess interest, features, and content.

Results
In phase 1, we found that CVD risk factors included high blood pressure, myocardial infarction, stroke, and diabetes. Cancer (prostate, colon, and others) was a common concern, as were mental health conditions. In phase 2, all participants completed the 12-item usability checklist with favorable feedback within 30 to 60 minutes. Beta-testing interviews suggested (1) mixed perceptions of health and HIV, (2) high risk for comorbid conditions, (3) virtual environment features were promising, and (4) the need for diverse avatar representations.

Conclusions
We identified several comorbid conditions of concern, and findings carry significant implications for mitigating barriers to preventive health screenings, given the shared risk factors between HIV and related comorbidities. Highly rated aspects of the virtual environment were anonymity; meeting others with HIV who identify as gay or bisexual; validating lesbian, gay, bisexual, transgender, queer, and others (LGBTQ+) images and content; and accessibility to CVD prevention education. Critical end-user feedback from beta testing suggested more options for avatar customization in skin, hair, and body representation. Our next phase will test the virtual environment as a new approach to advancing cardiovascular health equity in ethnic and racial sexual minority men with HIV.

Trial Registration
ClinicalTrials.gov NCT04061915; https://clinicaltrials.gov/study/NCT05242952

International Registered Report Identifier (IRRID)
RR2-10.2196/38348
Degenerative Cervical Myelopathy Awareness in Primary Care: UK National Cross-Sectional Survey of General Practitioners
Authors: Rufus-Toye Remi M , Rafati Fard Amir , Mowforth Oliver D , McCarron Luke V , Chan Kayen , Hirayama Yuri , Smith Emma K , Veremu Munashe , Davies Benjamin M , Brannigan Jamie F M 
Published: June 2024

Background
Degenerative cervical myelopathy (DCM) is a progressive neurological condition, characterized by spinal cord injury secondary to degenerative changes in the spine. Misdiagnosis in primary care forms part of a complex picture leading to an average diagnostic delay of 2 years. This leads to potentially preventable and permanent disability. A lack of awareness secondary to deficits in postgraduate education may contribute to these delays.

Objective
This study aims to assess the awareness of DCM in the setting of general practice.

Methods
General practitioners completed a quantitative web-based cross-sectional questionnaire. The 17-item questionnaire captured data regarding demographics, subjective awareness, and objective knowledge. The questionnaire was disseminated via professional networks, including via practice managers and senior practice partners. Incentivization was provided via a bespoke DCM fact sheet for those that completed the survey.

Results
A total of 54 general practitioners representing all 4 UK nations responded to the survey. General practitioners most commonly self-assessed that they had “limited awareness” of DCM (n=24, 51%). General practitioners felt most commonly “moderately able” to recognize a case of DCM (n=21, 46%). In total, 13% (n=6) of respondents reported that they would not be at all able to recognize a patient with DCM. Respondents most commonly reported that they were “moderately confident” in their ability to triage a patient with DCM (n=19, 41%). A quarter of respondents reported no prior introduction to DCM throughout their medical training (n=13, 25%). The mean score for knowledge-based questions was 42.6% (SD 3.96%) with the lowest performance observed in patient demographic and clinical recognition items.

Conclusions
General practitioners lack confidence in the recognition and management of DCM. These findings are consistent with the diagnostic delays previously described in the literature at the primary care level. Further work to develop and implement educational interventions to general practitioner practices is a crucial step to improving patient outcomes in DCM.
Analisis Implementasi Kebijakan Program Indonesia Sehat dengan Pendekatan Keluarga di Puskesmas Pasir Panjang Kota Kupang
Authors: Rahmawati Eka Muftiana , Littik Serlie K. A. , Nayoan Christina R. 
Published: June 2024

Latar Belakang : Program Indonesia Sehat dengan Pendekatan Keluarga merupakan program yang menitikberatkan peran keluarga untuk mengoptimalkan pelayanan kesehatan berbasis keluarga. Capaian IKS Puskesmas yang masih rendah dan tidak mengalami perubahan sejak proses pendataan mendorong penulis untuk melihat lebih dalam proses implementasi PIS-PK di Puskesmas Pasir Panjang.Tujuan : Penelitian ini dilakukan untuk mengetahui bagaimana implementasi PIS-PK di Puskesmas Pasir Panjang dari segi komunikasi, sumber saya, disposisi dan struktur birokrasi.Metode : Penelitian ini dilakukan dengan metode pendekatan kualitatif deskriptif Pengumpulan data kualitatif dilakukan dengan cara wawancara kepada informan kunci, dan dilakukan analisis data melalui tahapan reduksi, pemusatan data, verifikasi dan analisis naratif untuk tentang model implementasi meliputi variabel komunikasi, sumber daya, disposisi dan struktur birokrasi.Hasil : Implementasi PIS-PK masih belum masimal dari variabel komunukasi kepada pelaksana kebijakan, sumber daya manusia dan anggaran, disposisi dan struktur birokrasi baik pimpinan puskesmas dan dinas kesehatan kotaSaran : perlu adanya koordinasi antara pelaksana, dinas kesehatan, lintas sektor dan sasaran tentang tujuan pelaksanaan PIS-PK sehingga dapat saling memberikan motivasi dan saling sinergi dalam perbaikan pelaksanaan implemtasi sebelumnya untuk capaian indeks keluarga sehat sesuai target keluarga kategori sehat.
Analisis kebijakan RAD Membangun Generasi Unggul melalui 8000 HPK di Kota Yogyakarta
Authors: Siswati Tri , Tjaronosari Tjaronosari , Susilo Joko , Sujiyatini Sujiyatini , Wuryaningsih Dewanti Evita Julian Wulandari , Utami Siti Budi 
Published: June 2024

The target of accelerating stunting reduction includes the period from pregnancy to adolescence, where every period of life has the opportunity to correct past growth failures. This study aims to present the results of the evaluation of the implementation of the Regional Action Plan (RAD) policy to build a superior generation through the First 8000 Days of Life (HPK) in 2021–2025 Yogyakarta City. The method used in this study is a mix of quantitative and qualitative methods. Quantitative research is carried out with a cross-sectional design, including analysis of the health situation, related factors, and program achievements. Data sources are obtained from routine data report documents and other official websites. Data is analyzed in a descriptive way by presenting proportions, trends, narratives, tables, and figures. Meanwhile, qualitative research is carried out by designing rapid assessment procedures (RAP) through FGD and in-depth interviews and analyzed manually based on themes and sub-themes. The instruments of this research are an interview guide, FGD guide and a recorder. The results stated that the prevalence of stunting in Yogyarta City has decreased. Until the end of 2023, the evaluation of stunting reduction is carried out using indicators in accordance with Presidential Regulation 72 of 2021 concerning the acceleration of stunting reduction, but the evaluation with the indicators listed in RAD 8000 HPK has not been carried out comprehensively. Some factors that support the reduction in stunting prevalence are the commitment of regional leaders, good stunting governance, program achievement that is high or above the target, the human development index (HDI), and the high average length of schooling. Meanwhile, the inhibiting factors in reducing stunting are economic inequality, knowledge, community participation in Posyandu, littering behavior, and access to health insurance services for non-KTP residents of Yogyakarta City.
Confusion and Diffusion Techniques for Image Encryption Process Based on Chaos System
Authors: Magfirawaty Magfirawaty  , Ariska Allamanda  , Malika Ayunasari  , Muhammad Nadhif Zulfikar  
Published: June 2024

Face recognition uses biometric technologies to identify humans based on their facial characteristics. This method is commonly used to restrict information access control. The benefits of face recognition systems encompass their ease of use and security. The human face recognition process consists of face detection, face tracking, and face recognition. The process uses some algorithms: the Viola-Jones for face detection, the Kanade-Lucas-Tomasi (KLT) for face tracking, and the principal component analysis (PCA) for face recognition. Furthermore, this research proposed face recognition with an encryption process to protect the data stored in a database. The encryption process consists of two main processes: confusion and diffusion. The confusion process is randomizing the position of the original image pixels. This research utilized the Arnold’s cat map (ACM) for the confusion process, and the diffusion process was performed using the XOR operation with the key generated from the 1D chaos system. Three different 1D chaos systems, namely logistic map, Bernoulli map, and tent map, were compared to see which chaos system had the best encryption results. Tests were conducted by comparing various parameters on the three proposed 1D chaos systems, including correlation coefficient, histogram analysis, entropy value, number of pixel rate changes (NPCR), and unified average change intensity (UACI). Based on testing the image encryption results, the diffusion process utilizing the tent map produced the best image encryption compared to other chaotic systems.
Asupan Energi, Protein, Kalium dan Cairan dengan Status Gizi (SGA) Pasien GGK yang Menjalani Hemodialisa
Authors: Sherly Sherly , Putra Deri Andika , Siregar Afriyana , Yuliantini Emy 
Published: June 2024

Penyakit Ginjal Kronis adalah gangguan fungsi ginjal yang progresif dan tidak dapat pulih kembali. Salah satu terapi yang tepat bagi penderita gagal ginjal kronik adalah hemodialisa. untuk mengetahui Hubungan Asupan Energi, Protein, Kalium Dan Cairan Terhadap Status Gizi (SGA) Pada Pasien Hemodialisa Di RSUD Harapan Dan Doa Kota Bengkulu Tahun 2020. Design penelitian ini Observasional Analitik dengan pendekatan Cross Sectional. Teknik pengambilan sampel dengan metode Purposive Sampling dengan Jumlah sampel 36 pasien. Analisis statistik menggunakan uji chi- square. Ada hubungan yang bermakna antara asupan energi (p= 0,000), ada hubungan yang bermakna antara asupan protein (p=0,000), ada hubungan yang bermakna antara asupan kalium (p=0,025), tidak ada hubungan yang bermakna antara asupan cairan (p=0,056) dengan status gizi berdasarkan skrining SGA di RSUD Harapan dan Doa Kota Bengkulu tahun 2020. Rata-rata asupan zat gizi pasien hemodialisa yang diambil menggunakan Food Recall 24 jam yaitu asupan energi 1406 kkal, protein 56 gram, kalium 1368 mg dan cairan 669 ml.
Hubungan Asupan Energi dan Protein, Kualitas Tidur, dan Aktivitas Fisik Terhadap Prestasi Belajar di SMK Tunas Grafika Informatika 2020
Authors: Mulia Dinda Anggita , Amar Muhammad Ikhsan , Sufyan Dian Luthfiana , Simanungkalit Sintha Fransiske 
Published: June 2024

Prestasi belajar di sekolah dapat menjadi salah satu indikator kualitas seorang remaja. Prestasi belajar dipengaruhi oleh faktor internal dan eksternal. Kesehatan merupakan salah satu faktor internal yang paling melekat pada remaja. Kesehatan remaja dapat didukung dari gaya hidup meliputi asupan makanan, pola tidur danaktivitas fisik. Tujuan penelitian ini adalah untuk menganalisis hubungan asupan energi, asupan protein, kualitas tidur, dan aktivitas fisik remaja di SMK Tunas Grafika Informatika 2020. Penelitian ini dilaksanakan dengan metode observasional serta pendekatan Cross Sectional. Populasi penelitian ini adalah siswa SMK Tunas Grafika Informatika Th.2020/2021 dengan jumlah sampel 101 diambil dengan metode Stratified Random Sampling. Data diambil melalui pengisian kuesioner dan wawancara secara daring. Uji statistik menggunakan uji Spearman Rank dan Uji Kendall’s Tau b. Hasil uji statistik menunjukan terdapat hubungan signifikan antara prestasi belajar dengan asupan energi (P value= 0,012), asupan protein (P value= 0,002) kualitas tidur (P value= 0,001), dan aktivitas fisik (P value= 0,002), Hasil uji statistik korelasi menunjukan bahwa prestasi belajar berkorelasi positif dengan asupan energi dengan kekuatan lemah, asupan protein dengan kekuatan sedang, kualitas tidur dengan kekuatanan sedang, dan aktivitas fisik dengan kekuatan lemah.
Analisis Indeks Glikemik Permen Jelly Ekstrak Sari Daun Suruhan (Peperomia pellucida) untuk Penderita Diabetes
Authors: Nur Ira Mahyuni , Zusriadi Brenda Febrina , Supu Nur Zenab Karim , Solang Margaretha 
Published: June 2024

Diabetes mellitus menjadi salah satu penyakit yang dominan diderita oleh masyarakat Indonesia. Penyakit ini ditandai dengan naiknya kadar glukosa darah karena sekresi insulin di dalam tubuh terganggu. Tanaman suruhan (Peperomia pellucida) adalah tanaman yang memiliki aktivitas antidiabetes yang dapat menghambat kerja enzim α-milase. Penelitian ini bertujuan untuk menganalisis nilai indeks glikemik permen jelly ekstrak sari daun suruhan sebagai makanan selingan penderita diabetes. Metode penelitian ini menggunakan Rancangan Acak Lengkap (RAL) tiga perlakuan yakni A1 (0%), A2 (15%), dan A3 (30%) dengan ulangan sebanyak tiga kali. Kadar karbohidrat dan kadar glukosa dianalisis dengan uji parametrik One-Way Anova, analisis uji organoleptik dengan uji non parametric Kruskall Wallis Test dan akan dilanjutkan apabila terdapat perbedaan. Sedangkan, analisa data uji indeks glikemik dengan aturan trapezoid. Hasil penelitian analisis kadar glukosa dan kadar karbohidrat menunjukkan bahwa terdapat perbedaan signifikan (p=0,015) dan (p=0,000). Sedangkan, pada uji organoleptik dengan empat parameter menunjukkan tidak ada perbedaan nyata yang signifikan (p>0,05). Formula permen jelly terpilih adalah A1 dengan indeks glikemik rendah sebesar 35,90 dan beban glikemik sedang sebesar 10,69.
Rasio Platelet Limfosit (PLR) sebagai Penanda Risiko Gangguan Fungsi Kognitif pada Pasien Diabetes Melitus Tipe 2
Authors: Wulaa Nurwapina Langga , Muis Abdul , Maricar Nadra , Masadah Rina , Sompa Andi Weri , Umar Husaini 
Published: June 2024

Penelitian ini bertujuan untuk mengetahui hubungan ratio platelet limfosit (PLR) dengan fungsi kognitif pada pasien DMT2. Penelitian ini menggunakan rancangan penelitian observasional analitik dengan desain cross-sectional. Populasi penelitian adalah penderita DMT2 yang datang ke Poli Rawat Jalan RSWS dan RS Jejaring Pendidikan yang telah didiagnosis DMT2 oleh dokter spesialis penyakit dalam sesuai kriteria PERKENI 2015. Adapun besar sampel penelitian ditetapkan sebanyak 41 pasien. Variabel yang digunakan dalam penelitian ini adalah: Variabel Independen (Rasio platelet limfosit), Variabel Dependen (Gangguan kognitif), Variabel Antara (Proses inflamasi kronik), Variabel Perancu (Usia, jenis kelamin, Pendidikan, lama onset DMT2, komorbiditas), Variabel Kontrol (Stroke, Alzheimer, dementia lewy’s body, epilepsy). Analisis data yaitu analisis bivariat menggunakan uji Pearson atau Rank Spearman untuk menilai koefisien R, dan analisis multivariate menggunakan analisis regresi linier berganda. Data diolah melalui program SPSS. Hasil penelitian yaitu korelasi negatif antara nilai PLR dengan fungsi kognitif pada pasien DMT2. Semakin tinggi nilai PLR maka akan fungsi kognitif semakin rendah. Kemudian, Pada tingkat domain fungsi kognitif terdapat korelasi negatif antara nilai PLR dengan domain fungsi eksekutif, visuospasial, dan memori pada pasien DMT2. Adapun nilai cut-off pada nilai PLR untuk mendiagnosis gangguan kognitif adalah 186,1 dengan sensitivity: 57.58% dan specificity: 87,50%. Kesimpulan yaitu PLR dapat menjadi penanda risiko terjadinya gangguan fungsi kognitif pada pasien DMT2. Peningkatan nilai PLR dapat dikaitkan dengan penurunan fungsi kognitif pada pasien DMT2, terutama pada domain fungsi eksekutif, visuospasial, dan memori.
The relationship between depression, anxiety, chronic pain and pain pressure threshold of the masseter muscle in healthy young subjects. A pilot study
Authors: Kruk-Majtyka Weronika , Marciniak Tomasz 
Published: June 2024

Abstract

Study aim: The correlation between pain and emotional status in subjects with temporomandibular disorders (TMD) is established. Nevertheless, there is a lack of up-to-date findings based on objective assessment of pain using a digital algometer on the mastication muscles. The aim of this study was to investigate the relationship between the emotional status and the chronic pain pressure threshold (PPT).

Material and methods: Thirty-eight subjects were screened for the existence of temporomandibular disorders with the 3Q/TMD questionnaire for chronic pain (GCPS) and emotional status (PHQ-9 and GAD-7). The results were evaluated in comparison with the PPT measured with a digital algometer on the masseter muscles. Each subject was examined three times (at 1 and 7 months after the initial examination). Chronic pain scores (GCPS) were found to be higher in the TMD group in all three examination sessions (p < 0.05).

Results: Pain, depression and anxiety levels were higher in female subjects regardless of the existence of TMD, but only some differences were significant. A correlation between chronic orofacial pain scores and PPT was found in 2 out of 3 examination sessions.

Conclusion: The PPT scores for the masseter muscles did not correlate with the emotional state in the study group.