bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results from a 9‐year Intensive Safety Surveillance Scheme (IS3) in miglustat (Zavesca®)‐treated patients
Authors: Brand Monika , Muller Audrey , Alsop Jonathan , van Schaik Ivo N. , Bembi Bruno , Hughes Derralynn 
Published: February 2015

AbstractBackgroundFollowing approval in the EU in 2002 and the USA in 2003, an Intensive Safety Surveillance Scheme (IS3) was initiated to educate prescribers on the appropriate use of miglustat for the treatment of type I Gaucher disease (GD1), and to actively solicit safety‐relevant information. This report summarises data from all patients enrolled in IS3 between its initiation in 2003 and its closure in October 2012.MethodsThe IS3 was a prospective observational drug registry with a secure internet‐based data capture system. All patients receiving miglustat at participating sites received standard medical care according to routine medical practice. Data on patient and disease characteristics were collected at patient enrolment, subsequent follow‐up visits and treatment discontinuation (if applicable). Data were summarised using descriptive statistics.ResultsDuring the 9 years of IS3, 407 patients were enrolled at 111 sites across 15 European countries. Approximately half (n = 202) had GD1, and half had other diseases (mainly Niemann–Pick disease type C (NP‐C), for which miglustat was approved in Europe in 2009). In total, 368 patients had data from at least one follow‐up visit, 192 of whom had GD1. IS3 provided data from 798 patient‐years exposure to miglustat. Safety‐relevant data were consistent with earlier published 5‐year findings from IS3, the safety profile reported for miglustat in GD1 clinical trials and other published information on GD1 manifestations.ConclusionsOverall, the results of this long‐term safety surveillance programme were in line with the well‐known, documented safety profile of miglustat. Copyright © 2015 John Wiley & Sons, Ltd.
Homogeneous synthesis of partially substituted cellulose phenylcarbamates aiming at chiral recognition
Authors: Chen Weiwei , Zhang Mei , Feng Ye , Wu Jin , Gao Xia , Zhang Jinming , He Jiasong , Zhang Jun 
Published: February 2015

AbstractHomogeneous carbanilation of cellulose with nine kinds of substituted phenyl isocyanates, in which the substituents were varied from electron‐donating to electron‐withdrawing groups, was carried out in 1‐allyl‐3‐methylimidazolium chloride (AmimCl) without any catalyst. The degree of substitution (DS) of cellulose phenylcarbamates in a range from 0 to 3 was readily controlled by altering reaction temperature, reaction time and molar ratio of phenyl isocyanate/anhydroglucose unit. Furthermore, the electronic effect of the substituents on the aromatic ring had a prominent impact on the reactivity of phenyl isocyanates. The phenyl isocyanates with stronger electron‐withdrawing substituents exhibited a higher reactivity. A plot of DS and Hammett substituent constants exhibited linearity with a positive slope. Subsequently, four kinds of partially substituted cellulose phenylcarbamates with DS of 2.0 were synthesized successfully in AmimCl, and then employed as coated‐type chiral stationary phases (CSPs) for high‐performance liquid chromatography. The enantioseparation results demonstrated that these CSPs exhibited high chiral recognition abilities for some racemates. The substituents on the phenyl moieties had a considerable effect on the chiral recognition ability of cellulose phenylcarbamate‐based CSPs. © 2015 Society of Chemical Industry
Version 4.0 of PaxDb: Protein abundance data, integrated across model organisms, tissues, and cell‐lines
Authors: Wang Mingcong , Herrmann Christina J. , Simonovic Milan , Szklarczyk Damian , von Mering Christian 
Published: February 2015

Protein quantification at proteome‐wide scale is an important aim, enabling insights into fundamental cellular biology and serving to constrain experiments and theoretical models. While proteome‐wide quantification is not yet fully routine, many datasets approaching proteome‐wide coverage are becoming available through biophysical and MS techniques. Data of this type can be accessed via a variety of sources, including publication supplements and online data repositories. However, access to the data is still fragmentary, and comparisons across experiments and organisms are not straightforward. Here, we describe recent updates to our database resource “PaxDb” (Protein Abundances Across Organisms). PaxDb focuses on protein abundance information at proteome‐wide scope, irrespective of the underlying measurement technique. Quantification data is reprocessed, unified, and quality‐scored, and then integrated to build a meta‐resource. PaxDb also allows evolutionary comparisons through precomputed gene orthology relations. Recently, we have expanded the scope of the database to include cell‐line samples, and more systematically scan the literature for suitable datasets. We report that a significant fraction of published experiments cannot readily be accessed and/or parsed for quantitative information, requiring additional steps and efforts. The current update brings PaxDb to 414 datasets in 53 organisms, with (semi‐) quantitative abundance information covering more than 300 000 proteins.
Distributed flood attack detection mechanism using artificial neural network in wireless mesh networks
Authors: Khan Muhammad Altaf , Khan Shafiullah , Shams Bilal , Lloret Jaime 
Published: February 2015

AbstractMulti‐hop wireless mesh networks (WMNs) are increasingly growing interest as a promising technology for high‐speed network access. WMNs are integrated with other networks such as Internet, sensor networks, and cellular networks through gateways. Therefore gateways in WMNs are prone to various security threads and can be easily exploited by the attacker from any part of the Internet to launch a distributed flooding attack to compromise computer systems, affect the network performance, and destruct the services. Many approaches have been proposed by researchers in this regard but still more efforts are needed in terms of accuracy and efficiency. In this research paper, we will propose an artificial neural network‐based technique for detection of distributed flooding attacks to things such as sensors or actuators in WMNs called the distributed flood attack detector. In our simulation, sample dataset used to train and test the artificial neural network is generated using NS‐2 network simulator. Simulation results and real system implementation proved that the distributed flood attack detector can be used in a real network environment to detect the intermediate and severe distributed flood attacks with low‐false positive and false‐negative rates. Copyright © 2015 John Wiley & Sons, Ltd.
Seasonal change in the wetting characteristics of the cuticle of the Collembola Cryptopygus clavatus (Schött, 1893)
Authors: Gundersen Håkon , Thaulow Christian , Leinaas Hans Petter 
Published: February 2015

AbstractThe littoral Collembola Cryptopygus clavatus spends the summer submerged, grazing on algae under water, and the winter on dry land. The cuticles of Collembola are, in general, highly water repellent, often superhydrophobic; the cuticle of C. clavatus has, in contrast, been described as not water repellent. Wetting properties are closely tied to surface structuring, and previous studies of Collembola cuticles have used the pattern of cuticular granules to explain the superhydrophobic properties of these cuticles. The wetting properties of the cuticles of C. clavatus were measured on animals acclimated to summer and winter. A significant difference in wetting performance was observed. Animals acclimated to winter conditions showed superhydrophobic non-wetting properties. Animals acclimated to summer conditions were not superhydrophobic, water droplets readily adhered to their cuticles. This large change in wetting behavior of the cuticle could not be explained by changes in the cuticular surface structure, which were very limited. Instead, we suggest a change in the epicuticular wax layer could explain the differences.
Lipid accumulation by Rhodococcus rhodochrous grown on glucose
Authors: Shields-Menard Sara A , Amirsadeghi Marta , Sukhbaatar Badamkhand , Revellame Emmanuel , Hernandez Rafael , Donaldson Janet R , French W Todd 
Published: February 2015

Abstract
Biodiesel is an alternative fuel made from costly vegetable oil feedstocks. Some microorganisms can accumulate lipids when nutrients are limited and carbon is in excess. Rhodococcus rhodochrous is a gram-positive bacterium most often used in bioremediation or acrylamide production. The purpose of this study was to investigate and characterize the lipid accumulation capabilities of R. rhodochrous. Shake flasks and a large-scale fermentation were used to cultivate R. rhodochrous in varying concentrations of glucose. R. rhodochrous achieved almost 50 % of dry cell mass as lipid when grown in 20 g/L of glucose. Wax esters and triglycerides were identified in R. rhodochrous lipid extract. The transesterified extractables of R. rhodochrous consisted of mostly palmitic (35 %) and oleic (42 %) acid methyl esters. This study shows R. rhodochrous to be an oleaginous bacterium with potential for application in alternative fuels.
Quantitative Analysis of TAG in Oils Using Lithium Cationization and Direct‐Infusion ESI Tandem Mass Spectrometry
Authors: Ramaley Louis , Herrera Lisandra Cubero , Melanson Jeremy E. 
Published: February 2015

AbstractThis study was undertaken to determine whether triple‐stage mass spectrometry (MS3) could be employed to obtain quantitative and regioisomeric data from complex oil samples without the need for a chromatographic step in the analysis protocol. Lithium‐7 trifluoroacetate and electrospray ionization were used to form lithium adducts of the triacylglycerols (TAG) in a fish oil sample. The first‐generation precursor ion was the lithium‐TAG adduct, the second‐generation precursor ion was formed by loss of a neutral acid side chain in the first fragmentation. The ions used for analysis were formed in the second fragmentation by loss of the lactones of the acid side chains remaining after the first fragmentation. This analysis scheme provided quantitative and regioisomeric data without interference from TAG in the sample other than TAG with the same acyl carbon number, one more double bond, and two acyl side chains in common with the analyte. Even in this case a majority of the interferences could be estimated and compensated. Analysis of synthetic samples containing the fish oil matrix indicated that both absolute and relative quantitative data could be obtained with average errors of approximately 5 %. The method proved well suited to routine analyses of complex oil samples.
Longitudinal Evaluation of Clinical and Colonization Methicillin-Resistant Staphylococcus aureus Isolates Among Veterans
Authors: Stenehjem Edward , Crispell Emily K. , Rimland David , Farley Monica M. , Satola Sarah W. 
Published: February 2015

Using the Veterans’ Health Administration MRSA Directive as a platform to collect methicillin-resistant Staphylococcus aureus (MRSA) colonization isolates and an active MRSA infection surveillance program, the genetic relatedness of colonization and infection isolates was evaluated. Infection and colonization strain concordance was found in 85.7% of patients. The USA 500 MRSA strain was identified in 31.8% of patients.Infect Control Hosp Epidemiol 2015;00(0): 1–3
Environmental Transmission ofClostridium difficile: Association Between Hospital Room Size andC. difficileInfection
Authors: Jou Justine , Ebrahim John , Shofer Frances S. , Hamilton Keith W. , Stern John , Han Jennifer H. 
Published: February 2015

OBJECTIVETo evaluate the association between hospital room square footage and acquisition of nosocomialClostridium difficileinfection (CDI).METHODSA case-control study was conducted at a university hospital during the calendar year of 2011. Case patients were adult inpatients with nosocomial CDI. Control patients were hospitalized patients without CDI and were randomly selected and matched to cases in a 2:1 ratio on the basis of hospital length of stay in 3-day strata. A multivariate model was developed using conditional logistic regression to evaluate risk factors for nosocomial CDI.RESULTSA total of 75 case patients and 150 control patients were included. On multivariate analyses, greater square footage of the hospital room was associated with a significantly increased risk of acquiring CDI (odds ratio for every 50 ft2increase, 3.00; 95% CI, 1.75–5.16;P<.001). Other factors associated with an increased risk of CDI were location in a single room (odds ratio, 3.43; 95% CI, 1.31–9.05;P=.01), malignant tumor (4.56; 1.82–11.4;P=.001), and receipt of cefepime (2.48; 1.06–5.82;P=.04) or immunosuppressants (6.90; 2.07–23.0;P=.002) within the previous 30 days.CONCLUSIONSGreater room square footage increased the risk of acquisition of CDI in the hospital setting, likely owing to increased environmental contamination and/or difficulty in effective disinfection. Future studies are needed to determine feasible and effective cleaning protocols based on patient and room characteristics.Infect Control Hosp Epidemiol2015;00(0): 1–5
Intangible assets and decline: a population ecology perspective
Authors: Wei Yu-Chen , Lin Carol Yeh-Yun 
Published: February 2015

AbstractThis paper investigates the effects of environmental pressure, human capital, and social capital on organizational effectiveness and decline using a population ecology perspective. Panel data with 1,553 observations from 398 companies spanning 4 years in Taiwan were used for analyses. Research results indicate that several environmental pressure indicators significantly affect organization effectiveness and decline. Although human capital and social capital did not predict our outcome variables, human capital plays a moderating role in explaining the variation of the relationship between environmental pressure and organizational effectiveness. This paper provides a new perspective that suggests that organizations should accumulate intangible assets to resist the threat of external environmental pressure. The leading consumer electronics company Samsung is a good example supporting our argument that investment in human capital can produce commercial benefits, especially in tough economic times.
Adult nasal gliomas
Authors: Xie C , Hampal S , Li C 
Published: February 2015

AbstractBackground:Nasal gliomas are congenital neurogenic tumours that are mostly diagnosed in the perinatal period. They occur in 1 in 20 000–40 000 live births. Cases reported in adulthood are rare and the management in adults is controversial.Case report:A 55-year-old female had an incidental diagnosis of nasal glioma after routine endoscopic sinus surgery and polypectomy. Post-operatively, there was symptomatic improvement, but it was complicated by a cerebrospinal fluid leak.Conclusion:Most adults who present with nasal gliomas have non-specific nasal symptoms, and diagnosis is made from an incidental finding of heterotopic glial tissue. The management of nasal gliomas in adults is contentious. In contrast, management in the paediatric population is better established and the treatment is surgical excision. The relevant literature is reviewed.
La Santa Muerte in Mexico City: The Cult and its Ambiguities
Authors: KRISTENSEN REGNAR ALBÆK 
Published: February 2015

AbstractThis article explores the worship of La Santa Muerte through a geo-mapping of street altars in Mexico City followed by an ethnographic analysis of the devotees' relationships with the saint. I find that this saint has gained momentum among the fast-growing prison population over the last two decades. In contrast to studies that emphasise the desertification of mass incarceration elsewhere, this study finds that La Santa Muerte connects families across the social abyss of imprisonment. I suggest that the family-like relationships that devotees maintain with this saint are crucial to understanding her success. Rather than a one-dimensional sacred defender of criminals and police she is adopted by prisoners, prison officers, police and their families as a capricious ‘family member’, embracing the same ambivalence as the forces she helps to navigate.
Environment-related and host-related factors affecting the occurrence of lice on rodents in Central Europe
Authors: STANKO MICHAL , FRIČOVÁ JANA , MIKLISOVÁ DANA , KHOKHLOVA IRINA S. , KRASNOV BORIS R. 
Published: February 2015

SUMMARYWe studied the effects of environment- (habitat, season) and host-related (sex, body mass) factors on the occurrence of four species of lice (Insecta:Phthiraptera:Anoplura) on six rodent species (Rodentia:Muridae). We asked how these factors influence the occurrence of lice on an individual host and whether different rodent–louse associations demonstrate consistent trends in these effects. We found significant effects of at least one environment-related and at least one host-related factor on the louse occurrence in five of six host–louse associations. The effect of habitat was significant in two associations with the occurrence of lice being more frequent in lowland than in mountain habitats. The effect of season was significant in five associations with a higher occurrence of infestation during the warm season in four associations and the cold season in one association. Host sex affected significantly the infestation by lice in three associations with a higher frequency of infestation in males. Host body mass affected the occurrence of lice in all five associations, being negative in wood mice and positive in voles. In conclusion, lice were influenced not only by the host- but also by environment-related factors. The effects of the latter could be mediated via life history parameters of a host.
Course of cannabis use and clinical outcome in patients with non-affective psychosis: a 3-year follow-up study
Authors: van der Meer F. J. , Velthorst E. ,   Genetic Risk and Outcome of Psychosis (GROUP) Investigators
Published: February 2015

BackgroundProspective studies on the relationship between course of cannabis use and clinical outcome in patients with non-affective psychotic disorders are inconclusive. The current study examined whether (1) persistent, recently started, discontinued and non-cannabis-using patients with a psychotic disorder differed with regard to illness outcome at 3-year follow-up, and (2) whether timing of cannabis discontinuation was associated with course of clinical outcome.MethodThis 3-year follow-up study was part of a multi-center study in the Netherlands and Belgium (Genetic Risk and Outcome of Psychosis; GROUP). We used mixed-model analyses to investigate the association between pattern of cannabis use and symptoms, global functioning and psychotic relapse.ResultsIn our sample of 678 patients, we found persistent users to have more positive and general symptoms, worse global functioning and more psychotic relapses compared with non-users and discontinued users [Positive and Negative Syndrome Scale (PANSS) positive, p < 0.001; PANSS general, p < 0.001; Global Assessment of Functioning (GAF) symptoms, p = 0.017; GAF disability, p < 0.001; relapses, p = 0.038]. Patients who started using cannabis after study onset were characterized by worse functioning at baseline and showed an increase in general symptoms (including depression and anxiety) at the 3-year follow-up (p = 0.005). Timing of cannabis discontinuation was not associated with clinical outcome.ConclusionsThese findings suggest that cannabis use in patients with a psychotic disorder has a long-lasting negative effect on illness outcome, particularly when persistent. Treatment should focus on discouraging cannabis use.
Mapping the potential distribution of the Critically Endangered Himalayan Quail Ophrysia superciliosa using proxy species and species distribution modelling
Authors: DUNN JONATHON C. , BUCHANAN GRAEME M. , CUTHBERT RICHARD J. , WHITTINGHAM MARK J. , MCGOWAN PHILIP J. K. 
Published: February 2015

SummaryThe Critically Endangered Himalayan Quail Ophrysia superciliosa has not been reliably recorded since 1876. Recent searches of historical sites have failed to detect the species, but we estimate an extinction year of 2023 giving us reason to believe that the species may still be extant. Species distribution models can act as a guide for survey efforts, but the current land cover in the historical specimen record locations is unlikely to reflect Himalayan Quail habitat preferences due to extensive modifications. Thus, we investigate the use of two proxy species: Cheer Pheasant Catreus wallechi and Himalayan Monal Lophophorus impejanus that taken together are thought to have macro-habitat requirements that encapsulate those of the Himalayan Quail. After modelling climate and topography space for the Himalayan Quail and these proxy species we find the models for the proxy species have moderate overlap with that of the Himalayan Quail. Models improved with the incorporation of land cover data and when these were overlaid with the Himalayan Quail climate model, we were able to identify suitable areas to target surveys. Using a measure of search effort from recent observations of other galliformes, we identify 923 km2 of suitable habitat surrounding Mussoorie in Northern India that requires further surveys. We conclude with a list of five priority survey sites as a starting point.
Setting goal and implementation intentions in consultations between practice nurses and patients with overweight or obesity in general practice
Authors: van Dillen Sonja ME , Noordman Janneke , van Dulmen Sandra , Hiddink Gerrit J 
Published: February 2015

AbstractObjectivePatients with overweight or obesity increasingly attend general practice, which is an ideal setting for weight-loss counselling. The present study is the first to investigate the quality of weight-loss counselling provided by practice nurses in general practice to patients with overweight or obesity, in order to identify points for improvement.DesignAn observational checklist was developed to assess goal and implementation intentions and ‘missed opportunities for lifestyle counselling’. Comparisons were made with overall consultation goals set by practice nurses, as measured in a post-visit questionnaire.SettingDutch general practice.SubjectsOne hundred video-taped consultations (2010/2011) between practice nurses and patients with overweight or obesity.ResultsHalf of the consultations contained a goal intention, of which the majority aimed to change eating behaviour. Only part of these goal intentions could be considered implementation intentions. It appeared that actions (how elements) were not often included here. Lifestyle change was more often perceived as an overall consultation goal than weight change. Regarding patterns of overall consultation goals, the majority addressed only one lifestyle factor at a time. If practice nurses formulated weight change in their overall consultation goal, they also used goal or implementation intentions, especially for weight change. In a quarter of the consultations, practice nurses did not ask any further questions about weight, nutrition or physical activity to gain insight, which is an important ‘missed opportunity for lifestyle counselling’.ConclusionsMatching implementation intentions to the broader overall consultation goals of practice nurses would be meaningful, leading to desired goal-directed behaviours and subsequent goal attainment.