bluuebunny/crossref_metadata_2025_split huggingface dataset:
Developing an incentive‐based model for efficient product recovery and reverse logistics
Authors: Gautam Deepak , Bolia Nomesh 
Published: August 2024

AbstractThis study presents an inventive model aligning with sustainable development goals (SDGs) 11, 12, and 9. SDG 11 emphasizes sustainable urban aspects, SDG 12 centers on responsible consumption, and SDG 9 highlights resilient infrastructure. Focused on enhancing operational profits, the model integrates a robust reverse logistics network and policy framework to ensure safe disposal and environmental preservation. Employing the CPLEX solver software, we evaluated various methodologies, including proximity‐based allocation, set covering problems, p‐median allocation, and capacity‐relaxed models, to maximize profitability and efficiency in battery return systems. Our findings underscored the limitations of conventional proximity‐based methods, emphasizing the necessity of advanced optimization. Scenario 3, utilizing the p‐median problem, emerged as the most profitable, optimizing customer allocation and reducing distance‐related costs. Additionally, our sensitivity analysis highlighted the collection rate parameter's pivotal role in influencing customer behavior and overall system profitability. The study also emphasizes the significance of accessible collection centers, revealing disparities in accessibility across customer zones. These findings call for nuanced analyses to ensure equitable access. Implications include advocating for strategic policies to enhance collection rates, optimize center accessibility, and promote responsible disposal, benefiting policymakers, industry professionals, and environmental stakeholders. Ultimately, this research contributes to sustainable practices, fostering eco‐conscious societies, and accelerating progress toward SDGs.
Organisational identification and workers' well‐being: The mediating role of trust, meaning of work and self‐objectification
Authors: Teresi Manuel , Barattucci Massimiliano , Telesca Giovanni , Andrighetto Luca , Baldissarri Cristina , Pagliaro Stefano 
Published: August 2024

AbstractGiven the recognised benefits of organisational identification (OI) on workers' well‐being, we investigated the underlying mechanisms of this association in this work. We conducted a cross‐sectional study (N = 192) to examine the possible mediating role of three factors related to individuals' workplace experiences (organisational trust, the meaning of work and self‐objectification) in the relationship between OI and well‐being. Specifically, the research aims to examine the relationship between identification in the workplace and favourable well‐being outcomes. The study results demonstrated the significant indirect effects of the hypothesised model. In particular, OI was positively related to well‐being via increased trust and meaning of work and through a reduced self‐objectification experience. The findings highlight the significance of OI in relation to distal outcomes despite the potential presence of negative perceptual experiences within the relationship. This study seeks to offer innovative perspectives through which we can observe the relationship between less‐examined variables within the workplace, thus providing guidance for practitioners and researchers in this field.
CD34+ stromal cells/telocytes and their role in mouse lung development: Light microscopy, immunofluorescence, ultrastructural and scanning electron microscopy evidence
Authors: Dama Ganesh , Xue Chengxu , Zhang Yangxia , Li Dezhuang , Fan Jinyu , Qiao Liang , Xu Zhihao , Yang Ciqing , Liu Yanli , Abdullah Mohammad Farris Iman Leong Bin , Lin Juntang 
Published: August 2024

AbstractTelocytes (TCs), a novel type of mesenchymal or interstitial cell with specific, very long and thin cellular prolongations, have been found in various mammalian organs and have potential biological functions. However, their existence during lung development is poorly understood. This study aimed to investigate the existence, morphological features, and role of CD34+ SCs/TCs in mouse lungs from foetal to postnatal life using primary cell culture, double immunofluorescence, transmission electron microscopy (TEM) and scanning electron microscopy (SEM). The immunofluorescence double staining profiles revealed positive expression of CD34 and PDGFR‐α, Sca‐1 or VEGFR‐3, and the expression of these markers differed among the age groups during lung development. Intriguingly, in the E18.5 stage of development, along with the CD34+ SCs/TCs, haematopoietic stem cells and angiogenic factors were also significantly increased in number compared with those in the E14.5, E16.5, P0 and P7. Subsequently, TEM confirmed that CD34+ SCs/TCs consisted of a small cell body with long telopodes (Tps) that projected from the cytoplasm. Tps consisted of alternating thin and thick segments known as podomers and podoms. TCs contain abundant endoplasmic reticulum, mitochondria and secretory vesicles and establish close connections with neighbouring cells. Furthermore, SEM revealed characteristic features, including triangular, oval, spherical, or fusiform cell bodies with extensive cellular prolongations, depending on the number of Tps. Our findings provide evidence for the existence of CD34+ SCs/TCs, which contribute to vasculogenesis, the formation of the air‒blood barrier, tissue organization during lung development and homoeostasis.
Absorption, Metabolism, and Excretion of [14C]‐Labeled Anaprazole: A New Proton Pump Inhibitor, After a Single Oral Administration in Healthy Chinese Male Subjects
Authors: Xie Lijun , Xu Yanjun , Liu Wei , Zhou Chen , Guo Lian , Zhou Sufeng , Zhang Chen , Chen Juan , Zhu Bei , Ding Sijia , Li Huan , Zhang Lingling , Wang Li , Xu Lingmei , Shao Feng , Wang Lu 
Published: August 2024

AbstractAnaprazole is a proton pump inhibitor. This study aims to elucidate absorption, metabolism, and excretion pathways of anaprazole sodium in the human body. A total of 4 healthy Chinese male subjects were administered a single oral dose of 20 mg/100 µCi of [14C]‐anaprazole sodium enteric‐coated capsules. The whole blood, plasma, and excreta were analyzed for a total radioactivity (TRA) and metabolite profile. The cumulative radioactivity excretion rate was 93.2%, with 53.3% and 39.9% of the radioactive dose excreted in urine and feces, respectively, and 91.6% of dose recovered within 96 hours after dosing. The parent drug, anaprazole, showed good absorption and was extensively metabolized majorly to thioether M8‐1 via nonenzymatic metabolism. Overall, 35 metabolites were identified in plasma, urine, and fecal samples. Anaprazole was the most abundant component in plasma followed by the thioether M8‐1, accounting for 28.3% and 16.6%, respectively, of the plasma TRA. Thioether carboxylic acid XZP‐3409 (26.3% of urine TRA) and XZP‐3409 oxidation and dehydrogenation product M417a (15.1% of fecal TRA) were the major metabolites present in urine and feces, respectively. Anaprazole was undetectable in urine, while fecal samples showed traces (0.07% dose). Blood/plasma ratios of the radioactivity (approximately 0.60) remained consistent over time. Anaprazole showed good absorption and was extensively metabolized majorly to thioether M8‐1 via nonenzymatic metabolism, and cytochrome P450 3A4 also contributed to its metabolism in healthy individuals.
To‐Pack or Not‐to‐Pack: Towards Improved Graphite Electrochemical Oxidation Through Electrode Design
Authors: Subrati Ahmed , Gutiérrez‐Pineda Eduart , Moya Sergio E. 
Published: August 2024

AbstractFabrication of batch‐wise efficient, user‐ and environmentally‐friendly, and well‐defined yield methods for the synthesis of graphite oxide, the main precursor to graphene oxide and its reduced derivative, is an essential and robust research field, yet is sparingly investigated or innovated in recent years. This concept review showcases recent potential advances in the fabrication of electrochemical electrodes that meet aforementioned design parameters, wherein working electrode construction is seen to play a key role in shaping the yield characteristics and aiding the mechanistic understanding of efficiency of adopted methods. Particularly, those advances pave the way for new and various tunable design parameters by fabricating different methods of encapsulating graphite powder instead of using conventional bare monolith forms of graphite as working electrode. Encapsulation geometry, pressure, and matrix material, as well as powder size are examples of such tunable design parameters which are lacking in the monolith methods. The encapsulation validates authenticity of real‐time monitoring of electrochemical intercalation, exfoliation, and oxidation of graphite powder, thereby offering excellent and well‐defined control on yield.
Enhancing D/A Interactions via Porphyrin Isomerization to Improve Photovoltaic Performance
Authors: Wu Hanping , Wu Jifa , Tang Feng , Peng Xiaobin 
Published: August 2024

AbstractThe interactions between the electron donors and electron acceptors (D/A) play important roles for the performance of organic solar cells (OSCs). While the isomerization strategy is known to optimize molecular geometries and properties, the impacts of isomerization on the donors or acceptors in D/A interactions have not been extensively investigated. Here in, we innovatively investigated the impacts of donor isomerism on the D/A interactions by synthesizing two small molecule donors m‐ph‐ZnP2 and p‐ph‐ZnP2 by linking two functionalized porphyrins at the meta and para positions of phenyl groups, respectively. Compared with p‐ph‐ZnP2, m‐ph‐ZnP2 displays reduced self‐aggregation but enhanced interactions with PC61BM. Consequently, a much higher power conversion efficiency (PCE) of 5.43 % is achieved for the m‐ph‐ZnP2 binary OSCs than the p‐ph‐ZnP2 devices with a PCE of 2.03 %. The enhanced performance of m‐ph‐ZnP2‐based device can be primarily attributed to the stronger intramolecular charge transfer (ICT), the enhanced D/A interactions, the improved charge transfer, and the suppressed charge recombination. Furthermore, the ternary devices based on m‐ph‐ZnP2:Y6:PC61BM achieve a PCE of 8.34 %. In short, this work elucidates the relationship among the chemical structure, D/A interactions and device performance, providing valuable guidelines for designing efficient OSCs materials.
Correct stimulation of CD28H arms NK cells against tumor cells
Authors: Leau Raphaëlle , Duplouye Pierre , Huchet Virginie , Nerrière‐Daguin Véronique , Martinet Bernard , Néel Mélanie , Morin Martin , Danger Richard , Braudeau Cécile , Josien Régis , Blancho Gilles , Haspot Fabienne 
Published: August 2024

AbstractTumor evasion has recently been associated with a novel member of the B7 family, HERV‐H LTR‐associating 2 (HHLA2), which is mostly overexpressed in PDL‐1neg tumors. HHLA2 can either induce a costimulation signal when bound to CD28H or inhibit it by binding to KIR3DL3 on T‐ and NK cells. Given the broad distribution of CD28H expression on NK cells and its role, we compared two monoclonal antibodies targeting this novel NK‐cell engager in this study. We show that targeting CD28H at a specific epitope not only strongly activates Ca2+ flux but also results in NK‐cell activation. CD28H‐activated NK cells further display increased cytotoxic activity against hematopoietic cell lines and bypass HHLA2 and HLA‐E inhibitory signals. Additionally, scRNA‐seq analysis of clear cell renal cancer cells revealed that HHLA2+ clear cell renal cancer cell tumors were infiltrated with CD28H+ NK cells, which could be targeted by finely chosen anti‐CD28H Abs.
Exploring adolescent suicidal trajectories: The intersection of race/ethnicity, gender, and social connectedness
Authors: Luca Susan De , Yan Yueqi , Schueller Darerian , O'Donnell Kari 
Published: August 2024

AbstractIntroductionUnderstanding adolescent racial/ethnic and gender disparities in suicidal ideation and attempts longitudinally can help curb future suicidal risk.MethodsSurvey data (1994–2008) from the Longitudinal Study of Adolescent to Adult Health (Add Health study, n = 18,887) examined racial/ethnic and gender ideation and attempt disparities over four waves of data from across the United States (51% female; 51% White; Mage = 17.43 years at Wave 1). Repeated‐measures latent class analyses described how ideation and attempt patterns present longitudinally and how racial/ethnic minority groups predict different classes based on each wave and age‐appropriate social supports (i.e., parents, peers).ResultsThose most at‐risk disclosed ideation and some attempt risk in early adolescence (Waves 1 and 2) and mostly identified as female. The second most prevalent group first disclosed ideation in their 20s and predominately identified as non‐Hispanic White females. Peer connections were not significant for most groups except for non‐Hispanic White males in Wave 3, while Black females who reported stronger school connections had decreased ideation and attempt rates in Wave 1 but not 2 (just 1 year later). A negative link between social supports and high‐risk ideation and attempt classes was found among Black females, non‐Hispanic Whites, and Latinos overall.ConclusionsAs the United States becomes more diverse, understanding the unique ideation and attempt disparities are crucial. Tailoring interventions to include risk and protective mechanisms among intersectional communities could eradicate disparities. Longitudinal studies can illuminate how protective and risk factors can change over time and even within and among racial/ethnic and gender groups.
Adverse childhood experiences and psychological maladjustment in adolescence: The protective role of epistemic trust, mentalized affectivity, and reflective functioning
Authors: Tironi Marta , Charpentier Mora Simone , Liotti Marianna , Fiorini Bincoletto Alice , Tanzilli Annalisa , Cavanna Donatella , Lingiardi Vittorio , Speranza Anna Maria , Giovanardi Guido , Bizzi Fabiola 
Published: August 2024

AbstractIntroductionAdverse childhood experiences (ACEs) are psychosocial factors acknowledged as significant contributors to health consequences later in adolescence, including psychological maladjustment. The research suggests that, at a transdiagnostic and transtheoretical level, working on restoring epistemic trust (ET), mentalized affectivity (MA), and reflective functioning (RF) in adolescents with ACEs assumes a central role in the therapeutic process. However, there are still few studies that attempted to investigate the specific role of these sociocognitive factors in the detrimental positive association between levels of experienced ACEs during childhood and psychological maladjustment in nonclinical adolescents.MethodsA community sample of 306 Italian cisgender adolescents (61.4% assigned females at birth; age range 13–19 years old; Mage = 16.1, SD = 1.64) self‐reported ACEs (Childhood Trauma Questionnaire‐Short Form), psychological maladjustment (Strengths and Difficulties Questionnaire), ET (Epistemic Trust, Mistrust and Credulity Questionnaire), MA (Brief‐Mentalized Affectivity Scale for Adolescence), and RF (Reflective Functioning Questionnaire). A multiple mediation regression analysis has been performed to explore the association between ACEs and psychological maladjustment through the interaction with socio‐cognitive factors.ResultsACEs are positive predictors of psychological maladjustment later in adolescence. Regardless of gender differences, epistemic mistrust and credulity, processing and expressing emotions, and uncertainty about mental states mediated this association, while epistemic trust, identifying emotions, and certainty about mental states did not configure as significant mediators.ConclusionFindings suggest that ET disruptions and deficits in RF are risk factors, while MA is a protective factor within the link between ACEs and psychological maladjustment in adolescence. These links help to specify the role of sociocognitive factors in the development of mental problems in adolescents who have been exposed to adverse experiences in childhood.
Prevalence of metabolic syndrome in sickle cell disease patients: A cross‐sectional study at a tertiary hospital in Nepal
Authors: Khadayat Ramesh , Bishwakarma Mukesh , Pant Shubham , Bhatta Om Prakash , Bista Pariwesh Raj , Kamar Sher Bahadur 
Published: August 2024

AbstractBackgroundSickle cell disease (SCD) is the most common hemoglobinopathy caused by an autosomal recessive genetic disorder leading to increased morbidity and mortality rates. SCD is prevalent in the Tharu community in the lowland (Terai) region of Nepal. Prevalence of metabolic syndrome among adults with SCD is poorly studied.MethodologyThis prospective cross‐sectional study was conducted at Seti Provincial Hospital in Dhangadhi, Nepal, among 140 adolescents and adults with SCD, aged 15–60 years. Anthropometric and laboratory data were collected using an assisted questionnaire, and the SPSS software version 23 was used for data analysis. Descriptive and inferential statistics were used to summarize the presence of metabolic syndrome and were stratified in separate analyses by age and sex. National Cholesterol Education Program‐Adult Treatment Panel III criteria were used to define metabolic syndrome.AimThis cross‐sectional study aimed to assess the prevalence of metabolic syndrome among SCD patients with SCD registered at the Seti Provincial Hospital in Dhangadhi, Nepal.ResultsThe prevalence of metabolic syndrome in the study participants was 7.8%. Our study revealed 5% of the patients overweight, and 1.4% obese. In this study, the mean triglyceride level was 118.5 mg/dL, and the mean high‐density lipoprotein (HDL) level was 36.2 mg/dL (men) and 36.7 mg/dL (women). This study found that the mean fasting blood glucose level was 88.6 gm/dL. Similarly, 3.5% of patients had increased systolic blood pressure, and 7.8% had raised diastolic blood pressure. Study shows that changes in triglyceride level (p = 0.013), waist circumference, and HDL level (p = 0.0001 and 0.0048, respectively) are significantly associated with smoking or alcohol consumption; however, change in blood pressure (p = 0.013) and fasting blood sugar level (p = 0.086) are not associated with smoking or alcohol consumption.ConclusionStudy concluded that though a lower proportion of SCD patients met the criteria for metabolic syndrome than in studies conducted in developed countries, it is crucial to consider metabolic syndrome while managing patients with SCD. Nevertheless, the authors advocate a more comprehensive study to draw significant conclusions.
Exploring Codon Usage Patterns and Influencing Factors in Ranavirus DNA Polymerase Genes
Authors: Aktürk Dizman Yeşim 
Published: August 2024

ABSTRACTRanaviruses, members of the genus Ranavirus within the family Iridoviridae, have become a significant concern for amphibian populations globally, along with other cold‐blooded vertebrates, due to their emergence as a significant threat. We employed bioinformatics tools to examine the codon usage patterns in 61 DNA pol genes from Ranavirus, Lymphocystivirus, Megalocytivirus, and two unclassified ranaviruses, as no prior studies had been conducted on this topic. The results showed a slight or low level of codon usage bias (CUB) in the DNA pol genes of Ranavirus. Relative synonymous codon usage (RSCU) analysis indicated that the predominant codons favored in Ranavirus DNA pol genes terminate with C or G. Correlation analysis examining nucleotide content, third codon position, effective number of codons (ENC), correspondence analysis (COA), Aroma values, and GRAVY values indicated that the CUB across DNA pol genes could be influenced by both mutation pressure and natural selection. The neutrality plot indicated that natural selection is the primary factor driving codon usage. Furthermore, the analysis of the codon adaptation index (CAI) illustrated the robust adaptability of Ranavirus DNA pol genes to their hosts. Analysis of the relative codon deoptimization index (RCDI) suggested that Ranavirus DNA pol genes underwent greater selection pressure from their hosts. These findings will aid in comprehending the factors influencing the evolution and adaptation of Ranavirus to its hosts.
Three‐dimensional‐printed femoral diaphysis for biomechanical testing—Optimization and validation
Authors: Weinschenk Robert C. , Oldham Blaine M. , Nagaraja Kishore M. , Alam Faiqa , Samade Richard , Li Wei 
Published: August 2024

AbstractPolylactic acid (PLA) models of normal human femoral diaphyses were designed using three‐dimensional (3D) printing technology to create inexpensive, accessible, and reproducible specimens for flexural biomechanical studies. These models were subjected to three‐point bending and their response to loading was characterized. The anisotropic mechanical behavior of the 3D‐printed femurs and the influence of printing orientations, infill density, wall layers, resolution, and other printing parameters were explored to develop a design space. The objective of the design space was set to emulate the flexural biomechanical response of the normal human femur bones. Results show the 3D‐printed PLA diaphyseal femurs with 5% infill density, two–four wall layers, and a resolution of 200 µm resulted in a flexural strength of 184.8 ± 8.18 MPa. Models with 20% infill density and six wall layers resulted in a flexural modulus of 18.54 ± 0.543 GPa. These results emulate the biomechanical response of the normal human femur, as determined by historical target values derived from prior cadaveric and 3D printing data. With further research, inclusive of modeling the proximal and distal femur and more comprehensive biomechanical testing, 3D‐printed femurs may ultimately serve as a cheap, accessible biomechanical resource for surgeons and researchers.
Nitrogen transformation as affected by decomposition of 15N‐labeled cover crop shoots and roots
Authors: Süß Carla , Kemmann Björn , Helfrich Mirjam , Well Reinhard , Flessa Heinz 
Published: August 2024

AbstractBackgroundIncorporation of cover crop (cc) shoot and root biomass can have different effects on nitrogen (N) dynamics and the transformation of soil‐derived N and cc N.AimsThe objective was to determine the effects of different ccs, cc compartments (roots and shoots), and pretreatment of cc biomass (fresh vs. dried) on mineralization processes and on the transformation of soil and cc N following incorporation into a silty loam soil.MethodsSoil columns with incorporated 15N‐labeled root and shoot biomass of two cc species (winter rye and oil radish) and different pretreatments (dried and fresh) were incubated for 70 days at a constant temperature and soil moisture (8°C, 40% water‐filled pore space). Carbon and N transformation dynamics were determined repeatedly, distinguishing between N originating from cc biomass and from soil.ResultsNet CO2 emission was related to the amount of soluble cell components added with ccs. Net N mineralization was negatively related to the C:N ratio of cc biomass. The incorporation of dried cc biomass caused higher initial soil respiration and N immobilization than fresh biomass. All treatments with cc incorporation showed increased N2O emission. Emitted N2O‐N consisted mainly of cc N (55%–57%) in treatments with fresh shoot biomass, whereas soil N was the main source of N2O (75%) in the treatment with fresh oil radish roots. Recovery of cc 15N was affected by crop compartment and pretreatment. At the end of the incubation, it was 17.5%–42.3% in soil NO3−, 0.1%–8.1% in microbial biomass N, and less than 0.23% of cc N was found in cumulative N2O emission.ConclusionThe incorporation of cc roots and shoots had different effects on N mobilization and immobilization processes and on the partitioning of cc N. These processes can be influenced significantly by pretreatment of the added plant biomass (dried vs. fresh).