bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sustained knock down of PPARγ and bFGF presentation in collagen hydrogels promote MSC osteogenesis
Authors: Shao Shan , Cui Enmei , Xue Huimin , Huang Haiyun , Liu Gangli 
Published: October 2015

Abstract
Collagen hydrogels were considered as
favourable scaffolding for tissue engineering. It was
demonstrated that cytokines and siRNAs could be
efficiently retained by collagen hydrogels for controlled
release thereby enhancing their bioactivities. Basic
fibroblast growth factor (bFGF) was a stimulator for
osteogenic differentiation of mesenchymal stem cells
(MSC), and PPARγ was a key regulator in MSC osteogenic
differentiation. However, whether bFGF and PPARγ could
play synergetic roles within a 3D matrix to promote MSC
osteogenic differentiation was unknown. In the study,
bFGF and PPARγ targeting siRNAs were incorporated into
collagen hydrogels for MSC cultivation. Their optimal
concentrations in collagen hydrogels were determined.
The capacity of bFGF/siRNA-carrying hydrogels in
supporting osteogenic differentiation of MSCs was
systematically evaluated with multimodality of methods,
including flow cytometry, quantitative real-time PCR,
Western Blotting, as well as ALP activity and calcium
content determination. We demonstrated in 3D collagen
hydrogel that both bFGF and siRNA molecules were
efficiently retained, strengthening their effects on the
incorporated MSCs. Osteogenic analysis demonstrated
that the in-situ forming hydrogels carrying bFGF and
siRNAs potently promoted osteogenic differentiation of
incorporated MSCs, significantly superior to pure collagen
and bFGF-carrying collagen. Thus, collagen hydrogels
functionalized with bFGF and PPARγ targeting siRNAs
may be promising in bone tissue engineering.
Biofortification of maize grains with micronutrients by enriched biomass of blackcurrant seeds
Authors: Samoraj Mateusz , Tuhy Łukasz , Baśladyńska Sylwia , Chojnacka Katarzyna 
Published: October 2015

Abstract
Effect of the application of blackcurrant seed post-extraction residues (BS) enriched via biosorption with Zn(II), Mn(II) and Cu(II) was examined in field tests on maize. As a nominal dose (100%), 2.5 kg of zinc, 1 kg of manganese and 0.5 kg of copper per hectare, were applied. The preparation was applied, also, in higher doses (150%, 200%).

Crop yield and quality were assessed and multielemental analysis of grains was conducted. Grain yield obtained for maize treated with different doses of micronutrients (7.3 and 7.2 Mg ha-1 for BS 100% and BS 200%, respectively) was higher than in control group (6.2 Mg ha-1) and similar to a commercial reference product (7.1 Mg ha-1).

Bioavailability of micronutrients from BS was shown to be higher than from reference commercial fertilizer. The highest content of micronutrients delivered to plants was observed for groups fertilized with BS in nominal dose of micronutrients (1.79, 7.08 and 28.55 mg kg-1 for Cu, Mn and Zn, respectively). The content of each micronutrient was 5.6% (Cu) 12.1% (Mn) and 12.6% (Zn) higher than in untreated group and 8.9% (Cu) 9.7% (Mn) and 8.7% (Zn) higher than commercial reference micronutrient fertilizer. New biocomponents are cheap and biodegradable carriers of nutrients which can be released in controlled way.
Magnetic molecular imprinted polymers as a tool for isolation and purification of biological samples
Authors: Kwaśniewska Katarzyna , Gadzała-Kopciuch Renata , Buszewski Bogusław 
Published: October 2015

Abstract
Technology of molecularly imprinted polymers (MIP) has become very popular in recent decades. MIPs are primarily used in medical diagnostics, chromatographic separation and solid phase extraction (SPE); also as sensors and catalysts. In recent years there have been reported benefits of combining molecular imprinted polymers with additional features, e.g. magnetic properties, through the build-up of this type of material on magnetite particles (Magnetic Molecularly Imprinted Polymer – MMIP). This method produces a multifunctional material which has high selectivity and the ability to isolate the analyte from biological and environmental samples, allowing effective purification from such interferents as proteins and fats. This developing branch of new materials for the preparation and purification of complex sample matrices is an interesting alternative to materials routinely used to date, particularly with regard to the immunosorbents.
This paper summarizes recent reports regarding MMIP preparation and their application for purification and isolation of compounds from biological matrices.
Structural and mechanical defects of materials of offshore and onshore main gas pipelines after long-term operation
Authors: Maruschak Pavlo , Panin Sergey , Danyliuk Iryna , Poberezhnyi Lyubomyr , Pyrig Taras , Bishchak Roman , Vlasov Ilya 
Published: October 2015

AbstractThe study has established the main regularities of a fatigue failure of offshore gas steel pipes installed using S-lay and J-lay methods.We have numerically analyzed the influence of preliminary deformation on the fatigue life of 09Mn2Si steel at different amplitudes of cyclic loading. The results have revealed the regularities of formation and development of a fatigue crack in 17Mn1Si steel after 40 years of underground operation. The quantitative analysis describes the regularities of occurrence and growth of fatigue cracks in the presence of a stress concentration.
Determination of log moisture content using ground penetrating radar (GPR). Part 2. Propagation velocity (PV) method
Authors: Hans Guillaume , Redman David , Leblon Brigitte , Nader Joseph , La Rocque Armand 
Published: October 2015

Abstract
Log moisture content (MC) has been determined based on the propagation velocity (PV) of ground penetrating radar (GPR) signals. This approach is based on measuring the travel time of the GPR signal through the log, from which its PV and the apparent log dielectric permittivity can be retrieved. Linear regression between the log dielectric permittivity and MC was established for each of the investigated wood species (quaking aspen, balsam poplar, and black spruce), log state (thawed and frozen), and direction of measurement [on the log cross-section (CS) and through the bark (TB)]. CS and TB measurements led to different results depending on the log state and wood species. Linear models with different slopes were found for thawed (slope=6.4–9.8) and frozen (slope=12–29) logs due to the difference in the dielectric properties of the frozen and unfrozen water in wood. The models for quaking aspen and balsam poplar were very similar to each other and differed from that of black spruce in terms of slopes and intercepts. Generally, the PV method leads to poorer log MC prediction accuracy than the partial least squares method presented in Part 1 of this study.
Synthesis of platinum(II) complexes of 2-cycloalkyl-substituted benzimidazoles and their cytotoxic effects
Authors: Özçelik A. Berna , Gümüş Fatma , Sağkan Rahşan Ilıkçı , Muşabak Uğur 
Published: October 2015

Abstract
Five novel Pt(II) complexes with some 2-cycloalkyl-substituted benzimidazole carrier-ligands were synthesized and evaluated for their in vitro cytotoxic activities against HeLa and OVCAR-3 cell lines. A cell viability test revealed that [dichloro-bis(2-cycloheptylbenzimidazole) platinum(II)] is less cytotoxic than cisplatin, and its cytotoxic effect can be compared with that of carboplatin. Flow cytometric analysis revealed that this complex at 117 μM concentration causes apoptosis in approx. 72 % of the OVCAR-3 cell population. In addition, the complex was found to cause an increase in the SubG1 population of both OVCAR-3 and HeLa cells and to cause less apoptosis in HeLa cells than cisplatin.
Seasonal species interactions minimize the impact of species turnover on the likelihood of community persistence
Authors: Saavedra Serguei , Rohr Rudolf P. , Fortuna Miguel A. , Selva Nuria , Bascompte Jordi 
Published: October 2015

AbstractMany of the observed species interactions embedded in ecological communities are not permanent, but are characterized by temporal changes that are observed along with abiotic and biotic variations. While work has been done describing and quantifying these changes, little is known about their consequences for species coexistence. Here, we investigate the extent to which changes of species composition impact the likelihood of persistence of the predator–prey community in the highly seasonal Białowiez˙a Primeval Forest (northeast Poland), and the extent to which seasonal changes of species interactions (predator diet) modulate the expected impact. This likelihood is estimated extending recent developments on the study of structural stability in ecological communities. We find that the observed species turnover strongly varies the likelihood of community persistence between summer and winter. Importantly, we demonstrate that the observed seasonal interaction changes minimize the variation in the likelihood of persistence associated with species turnover across the year. We find that these community dynamics can be explained as the coupling of individual species to their environment by minimizing both the variation in persistence conditions and the interaction changes between seasons. Our results provide a homeostatic explanation for seasonal species interactions and suggest that monitoring the association of interactions changes with the level of variation in community dynamics can provide a good indicator of the response of species to environmental pressures.
High-Performance Modeling of Carbon Dioxide Sequestration by Coupling Reservoir Simulation and Molecular Dynamics
Authors: Bao Kai , Yan Mi , Allen Rebecca , Salama Amgad , Lu Ligang , Jordan Kirk E. , Sun Shuyu , Keyes David 
Published: October 2015

Summary
The present work describes a parallel computational framework for carbon dioxide (CO2) sequestration simulation by coupling reservoir simulation and molecular dynamics (MD) on massively parallel high-performance-computing (HPC) systems. In this framework, a parallel reservoir simulator, reservoir-simulation toolbox (RST), solves the flow and transport equations that describe the subsurface flow behavior, whereas the MD simulations are performed to provide the required physical parameters. Technologies from several different fields are used to make this novel coupled system work efficiently.
One of the major applications of the framework is the modeling of large-scale CO2 sequestration for long-term storage in subsurface geological formations, such as depleted oil and gas reservoirs and deep saline aquifers, which has been proposed as one of the few attractive and practical solutions to reduce CO2 emissions and address the global-warming threat. Fine grids and accurate prediction of the properties of fluid mixtures under geological conditions are essential for accurate simulations. In this work, CO2 sequestration is presented as a first example for coupling reservoir simulation and MD, although the framework can be extended naturally to the full multiphase multicomponent compositional flow simulation to handle more complicated physical processes in the future.
Accuracy and scalability analysis are performed on an IBM BlueGene/P and on an IBM BlueGene/Q, the latest IBM supercomputer. Results show good accuracy of our MD simulations compared with published data, and good scalability is observed with the massively parallel HPC systems. The performance and capacity of the proposed framework are well-demonstrated with several experiments with hundreds of millions to one billion cells.
To the best of our knowledge, the present work represents the first attempt to couple reservoir simulation and molecular simulation for large-scale modeling. Because of the complexity of subsurface systems, fluid thermodynamic properties over a broad range of temperature, pressure, and composition under different geological conditions are required, although the experimental results are limited. Although equations of state can reproduce the existing experimental data within certain ranges of conditions, their extrapolation out of the experimental data range is still limited. The present framework will definitely provide better flexibility and predictability compared with conventional methods.
Obtaining a Seismic Image Above the Top VSP Level Using Sea Surface Multiple - A Case Study in Nam Con Son Basin, Offshore Vietnam
Authors: Dac The Nguyen , Sanders Michael , Anh Tuan Ngo Nguyen , Solovyov Yuri , Ninh Tran Duc , Binh Kieu Nguyen , Luong Duc Le , Nguyen My T. , Thong Dang Trung , Van Du Dang , Van Dinh Tran , Van Lam Tran , Van Thang Nguyen , Le Quoc Thinh , Trung Nguyen Thanh , Dung Hoang 
Published: October 2015

Abstract
The Vertical Seismic Profile (VSP) technique is routinely used to create seismic images near the wellbore and traditionally only the up-going wavefield is used to image the subsurface below the receivers. The standard VSP technique does not give any information of the seismic image above the well trajectory. The objective here is to produce a seismic image above the top receiver depth up to sea floor using the downgoing multiples recorded in the VSP for a more complete seismic to well-tie.
A seismic source is positioned below Mean Sea Level and deployed near the wellhead. The source signal is recorded by a downhole receiver that is moved to cover a large number of depth levels in the well. The upgoing and downgoing arrivals are separated during processing; the up-going wavefield is used for subsurface illumination while the down- going wavefield and multiples are normally excluded from the processing. The standard VSP technique using VSP upgoing wavefield gives a seismic image along the range of receiver depths and below the well trajectory. However, a VSP image can also be obtained from the downgoing multiple sequences.
The main application of processing the sea surface multiple is to obtain a VSP image of formations above the top receiver depth which is unattainable with standard VSP technique. Results show that by using multiples, illumination coverage increases significantly in comparison to using primaries. In addition, reflectors above the shallowest receiver can be imaged by multiples, including the sea bed itself. This can be useful for different purposes such as shallow hazard identification for sidetracks or to avoid the expense of in-fill nodal seismic below the rig. We also show that the image obtained from the VSP multiples can have good resolution comparing to the surface seismic data, with better signal to noise ratio especially for the shallower reflectors. The VSP data is true amplitude, zero-phase and perfectly tied in depth and in time.
By using the sea surface related VSP multiples and the mirror imaging technique, the VSP image was extended successfully above the well trajectory up to the sea floor and shows a good correlation with the surface seismic. In this case study, we present some results of using the sea surface downgoing multiple for this unconventional VSP technique.
Surveillance Helps to Get a Better Understanding of Reservoir Connectivity in Azeri Part of ACG
Authors: Kuramshina Najiya , Ibrahimov Turan 
Published: October 2015

Abstract
Accurate and timely information is essential to monitor, control and manage reservoir and well performance. At the present, production and reservoir engineers as well as production geologists have a challenging task of managing oil and gas reservoirs. This requires a broad knowledge of the reservoir supported by fit-for-purpose integrated technologies and real time access to relevant data. In the Azeri-Chirag-Gunashli (ACG) field development, downhole information is commonly acquired through uses of LWD (logging while drilling) tools to obtain a standard log suite and obtain formation pressure measurement, production logging and well testing. In addition, Downhole Temperature Sensors (DTS) has been installed on someACG wells to provide continuous temperature readings across the reservoir so as to obtain critical understanding of reservoir behaviour, connectivity and fluid distribution.
Integration of DTS with Conventional Surveillance Data for Planning a Water Injection Target Location
Authors: Ismayilov Aydin , Sheydayev Ali , Lokke Paul , Rzayev Elshan , Kin Maria Lum 
Published: October 2015

Abstract
Integration of field surveillance data is important to understand reservoir description and dynamics particularly for waterflood schemes in which injector-producer connectivity is necessary for the expected oil recovery improvement. This paper shows an example of integration of DTS with other surveillance data to optimise the placement of a water injector in the complex northern part of the Deep Water Gunashli (DWG) field, Azerbaijan. Some of the dynamic data responses and trends were inconclusive but Distributed Temperature Sensor (DTS) evidence from two wells were instrumental in showing good pressure communication within the complex north-flank area, and water injection in the lower sands only.
Equipment for Offshore Oil Well Abandonment Operations
Authors: Ismayilov F. S. , Ibadov G. G. 
Published: October 2015

Abstract
For the safe and environmentally sound abandonment of wells in the marine environment it is necessary to insulate the producing formation and sources of cross-flows located aside and the annular pressure, preventing the release of the surface of the reservoir fluids.
A newly developed set of equipment enhances the reliability of abandonment by the hermetic and securely-linked overlap inside the production string at a certain depth below the producing formation, and the conductor's (technical) outside the column at the bottom of the sea.
Complex equipment can be used both for elimination of wells with existing platforms or platform, as well as the abandonment of wells without marine platform or platform, with a curved or broken stem out of the ability to perform the necessary technological tripping operations tubing. The latest version of the liquidation operations are carried out by specially-equipped craft equipped with a team of divers to perform tripping operations with rope techniques and parallel descent and ascent cementing hose to install a cement bridge in production casing.
Installation of liquidation cutting equipment includes a wellbore at 1,0 ÷ 1,2 m from the seabed and directly riser at the seabed.
Installing the packer-plug in the production string is fulfilled by downhole hydraulic jack run by a cable and two high-pressure hose. For reliable covering conductor's (technical) column there are fulfilled the run and installation of mechanical and hydraulic packer at outer surface of conductor packer.
The packaging arrangement allows for molding internal pressure as planted in the production casing packer plug-top and planted on the outer surface of the outer conductor's column packer inside.
Efficiency Improvement of Abrasive Jet Perforation
Authors: Chernyshov Sergey E. , Galkin Sergey V. , Krisin Nikolay I. , Turbakov Mikhail S. , Riabokon Evgenii P. 
Published: October 2015

Abstract
This paper shows and analyzes causes of oil reservoir properties deterioration. It describes changes in rock sate of stress during well drilling and perforation and analyzes existing technologies for oil well perforation. It is shown that abrasive jet perforation is the most efficient gentle method for well perforation. Upgraded abrasive jet perforation technology is proposed.
That takes into account speed of wearing out of nozzles made of composite materials under abrasive jet influence of sand carrier based on mathematical simulation of well conditions. Due to qualitative well perforation proposed technology increases well productivity and decreases energy consumption.
Experience of Microbial Enhanced Oil Recovery Methods At Azerbaijan Fields
Authors: Ibragimov Kh. M. , Abdullayeva F. , Guseynova N. I. 
Published: October 2015

Abstract
One of the advanced trends of present-day scientific and technological thought is the development of biotechnology, which solve such the challenges of our life as environmental, raw materials, food and energy. Biotechnology widely develops in the oil industry as well. Success of biotechnological stimulation methods is associated with the achievements of the petroleum microbiology. Studies of geochemical activity of microorganisms allow us to formulate and prove stimulation concept, which is based on the use of microorganisms - their ability to generate biogas, surface-active compounds, organic acids, polymers.
Microbial activity under reservoir conditions have a significant effect on physical and chemical properties of reservoir fluids, on the mechanism of the formation micro-processes and as a result affect oil recovery. Especially remarkable results have been obtained in depleted fields where application of conventional physical and chemical displacement methods is inefficient and unprofitable. Application of biotechnology in many advanced oil countries of the world gives positive results.
Due to the fact that onshore fields are in the late stage of development, marked by large residual oil reserves and degradation of their structure and quality, biotechnology is widely used in Azerbaijan. In the proposed report on the basis of long term experience we have provided the material on development and successful use of biotechnologies and their modifications in the oil fields of the republic.
Integration of Distributed Temperature Sensing Technology with Open Hole Gravel Packed Completions - The ACG Field Experience
Authors: John Colin P. , Ramnath Lawrence W. , Khankishiyev Ruslan V. , Hasanov Hikmet , Stephenson John , Keatinge Patrick D. 
Published: October 2015

Abstract
Fibre-Optic Distributed Temperature Sensing (DTS) has been integrated into sand control completions in the giant Azeri Chirag Guneshli (ACG) field offshore Azerbaijan to provide real time production logging and assist with the management of the field’s complex reservoirs. The optimization of gas lift for better well performance, well integrity risk identification and the determination of gas and water breakthrough locations are some of the benefits that the DTS data has provided. Deployment of the fibre-optic system in the ACG field required a fiber-optic wet-mate and the ability to deploy fiber to distances up to 12km. Lessons learned from those deployments have yielded a number of best practices and design optimizations for the integrated completion system. These optimizations include hardware and software advancements, procedural changes for improved deployment reliability and the incorporation of critical pre-job checks at the vendor’s workshop prior to equipment load out to the rig.
Maximizing reservoir potential and optimizing reservoir drainage is a critical part of the project economics for the ACG field and reliable sand control completions providing real time reservoir surveillance by means of DTS has proven to be a key technology for achieving this.