bluuebunny/crossref_metadata_2025_split huggingface dataset:
Shakespeare's Sonnet 145 and the Challenges of Legacy Criticism
Authors: Russell Shaun James 
Published: August 2024

Abstract
This article re-evaluates the merits of Shakespeare's Sonnet 145 and explores its critical legacy over the past half-century. While the sonnet has typically been seen as inferior due to its use of tetrameter rather than pentameter, one article from 1971 made a case for it being the first poem Shakespeare ever wrote. Rather than prompt critical debate, the theory presented in the article gained nearly universal acceptance and has been amplified ever since. The problem I identify is that the theory itself has been adopted without due scrutiny, and that when we approach Sonnet 145 from the standpoint that it is neither inferior nor juvenilia, we can then see how the supposed aberrations are potentially deliberate choices made by Shakespeare to underscore the poem's content.
A Correlation between Digital Literacy and EFL Students' Reading Comprehension at Higher Education
Authors: Sari Tri Ratna , Dewi Yana  , Edi Warno , Putri Aulia 
Published: August 2024

Proficient reading abilities are crucial for acquiring a language at an advanced level. Furthermore, students encounter digital information sources in the current technological era, underscoring the importance of digital abilities. Nevertheless, there is a dearth of research investigating the correlation between digital literacy and reading comprehension, particularly within the context of higher education institutions. The aim of the study is to examine whether there is a correlation between higher levels of digital literacy and reading comprehension among English as a Foreign Language (EFL) students in higher education. The research employed a correlational design. Non-probability sampling, specifically saturated sampling, was the sample technique used. The research sample consisted of twenty-five students enrolled in the fifth semester of the English Education Study Program at Universitas Riau Kepulauan. The research utilized questionnaires and test as the instruments to assess digital literacy and reading comprehension. The researcher administered the test to the sample after assessing its validity and reliability using SPSS version 23.0 for windows. The researcher employed the Pearson Product Moment to establish the relationship between digital literacy and reading comprehension. Based on data in a significance level of 5%, the analysis revealed that the r-count value (0.562) is greater than the r-table value (0.039). It approved Ha and declined Ho. The study revealed a significance correlation between students' digital literacy and reading comprehension. This research suggests integrating digital tools into learning and creating a learning environment that supports both digital skills and reading understanding simultaneously.
Pengaruh Motivasi Kerja Dan Disiplin Kerja Terhadap Produktivitas Kerja Karyawan Pada PT Hok Tong Plaju Palembang
Authors: Efendi Noven , Hendri Edduar , Kurniawan Muhammad 
Published: August 2024

ABSTRACTÂ This study aims to determine the effect of work motivation and work discipline on employee productivity at PT Hok Tong Plaju Palembang. This research method is a quantitative research method, with a population of 328 employees at PT Hok Tong Plaju Palembang. From a population of 382 employees, the Croum Production section was selected as many as 86 employees. Analysis of the data used is simple regression analysis, multiple linear regression analysis, correlation coefficient, coefficient of determination (R2), t test and F test. Based on the results of the study it can be seen that the significant value between work motivation and work discipline partially on employee productivity at PT .Hok Tong Plaju Palembang with a significant value of 0.000 <0.05 for the work motivation variable and 0.007 <0.05 for the work discipline variable. It can be concluded that together there is a significant influence between Work Motivation and Work discipline on Employee Productivity at PT Hok Tong Plaju Palembang.Â Keywords: Work Motivation, Work Discipline and Work Productivity.Â Â ABSTRAKÂ Penelitian ini bertujuan untuk mengetahui Pengaruh Motivasi Kerja dan Disiplin Kerja Terhadap Produktivitas Kerja Karyawan pada PT hok Tong Plaju Palembang. Metode penelitian ini adalah metode penelitian kuantitatif, dengan populasi sebanyak 328 orang karyawan yang ada pada PT Hok Tong Plaju Palembang. dari populasi sebanyak 382 karyawan dipilih bagian croum production sebanyak 86 orang karyawan. Analisis data yang digunakan adalah Analisis regresi sederhana, analisis regresi linier berganda, koefisien korelasi, koefisien determinasi (R2), Uji t dan Uji F. Berdasarkan hsil penelitian dapat diketahui bahwa nilai signifikan antara motivasi kerja dan disiplin kerja secara parsial terhadap produktivitas karyawan pada Pt.Hok Tong Plaju Palembang dengan nilai signifikan sebesar 0,000<0,05 untuk variabel motivasi kerja dan sebesar 0,007<0,05 untuk variabel disiplin kerja. Dapat disimpulkan bahwa secara bersama-sama terdapat pengaruh yang signifikan antara Motivasi Kerja dan disiplin Kerja Terhadap ProduktivitasÂ Kerja Karyawan pada PT Hok Tong Plaju Palembang.Â Kata Kunci : Motivasi Kerja, Disiplin Kerja dan Produktivitas Kerja.
Closing the gap between skills training and academic education at a military academy: An integrated instructional design model
Authors: Steven P. A. Hornstra  , Steven J. Durning  , Jaap A. Hoogenboezem  , Walther N. K. A. van Mook  
Published: August 2024

Linking skills training and academic education is a formidable challenge in many professional fields. At modern military academies, officer cadets learn military skills and strategic thinking, fostered by skills training and academic education respectively. As an example, we briefly elaborate on these two learning tracks at the Royal Military Academy of the Netherlands Defence Academy. However, skills training and academic education are often implemented in a non-integrated manner. Because officers have to integrate military skills and strategic thinking during actual military operations, it is paramount that officer cadets learn how to integrate these in a meaningful way. Therefore, we designed an innovative integrated instructional design (ID) model that aims to meet the needs of both military training and academic education. We herein describe the six-step design process of the resulting so-called TrEd ID model, based on the Nine events of instruction model and STAR Legacy, linked through the First Principles of Instruction. The TrEd ID model provides common ground to military instructors and civilian academicians at a military academy, encouraging mutual understanding and collaboration. Future research is needed to understand the potential value of the TrEd ID model in bridging the gap between skills training and academic education, and how to optimally prepare officer cadets for their roles.
Análisis y evaluación de parámetros de eficiencia de la señal en un sistema de transmisión sobre fibra óptica utilizando modulación QAM y empleando Optisystem
Authors: Barreno Gómez Henry Jeanpiere , Martínez Guashima Oswaldo Geovanny , López Ortega Jorge Rigoberto , Carrión Buenaño Darwin Paul 
Published: August 2024

Introducción: Este trabajo se aborda el diseño de un sistema de transmisión de comunicaciones ópticas haciendo uso de la modulación QAM y el software OptiSystem el cual va ayudar analizar la señal durante el proceso de transmisión, dando como resultados en las diferentes variaciones de este tipo de modulación como 4-QAM, 8-QA, 16-QAM, 32-QAM, 64-QAM a diferentes distancias, considerando también el tipo de fibra utilizada para largas distancias como es la monomodo, de esta manera los resultados arrojados a analizar van a ser el factor Q, BER, umbral, con los cuales se dará un análisis en cada uno de los casos antes mencionados. Objetivos: Analizar y evaluar los parámetros de eficiencia de una señal en un esquema de simulación de un sistema de comunicaciones ópticas. Metodología: La metodología utilizada para analizar y evaluar los diferentes parámetros de eficiencia de una señal, ha sido realizar simulaciones de un sistema de comunicaciones ópticas utilizando modulación QAM partiendo de un diagrama diseñado en el software OptiSystem con sus diferentes herramientas, la señal analizada va a ir de un transmisor a un receptor, considerando un medio el cual va a ser variable su distancia, y de la misma manera el tipo de fibra óptica considerada en este caso para largas distancias llega a ser monomodo por tener eficiencia de transmisión a largas distancias y así para lograr analizar los diagramas de ojo, la tasa de error de bit, umbral, y el factor de calidad de la señal a la recepción Resultados: Los resultados de este trabajo han sido satisfactorios ya que muestra en cada gráfico, los diferentes valores de desempeño de la señal con las variaciones que tiene la modulación QAM, siendo que en los diferentes casos existen un mejor rendimiento de la señal dependiendo de la distancia. Conclusiones: Este trabajo ha mostrado que la señal digital debe ser tratada según el servicio que se lo vaya a utilizar, siendo que en la modulación QAM va a ofrecer mayor eficiencia espectral cuando utiliza un orden superior como 64-QAM frente a uno de orden inferior, a coste de una mayor sensibilidad al ruido. Área de estudio general: Telecomunicaciones. Área de estudio específica: Comunicaciones Ópticas. Tipo de estudio: Original, proyecto técnico, comunicaciones ópticas.
Surgical Repair of Atrial Septal Defect with Severe Pulmonary Hypertension: A Case Report
Authors: Akter Tahmina , Mohammad Fazle Maruf  , Hossain Nazmul , Chowdhury A Quaium , Ahsan Uddin Mahmud  , Chowdhury Minhazur Rahman , Barua Subir 
Published: August 2024

This case report details the successful surgical repair of an atrial septal defect (ASD) in a 28-year-old female with severe pulmonary arterial hypertension (PAH), who presented with dyspnea, fatigue, and palpitations. The patient had a large secundum ASD (26 mm size) with bi-directional shunt and severe PAH, with a Pulmonary Arterial Systolic Pressure (PASP) of 107 mmHg and Mean Pulmonary Arterial Pressure (mPAP) of 57 mmHg, as revealed by echocardiography. The patient was optimized medically with diuretics, oxygen, and pulmonary vasodilators (Sildenafil & Ambrisentan), and was deemed eligible for surgical closure of the ASD. A pericardial patch was used to close the defect, and the patient's postoperative recovery was uneventful. Follow-up echocardiography showed a significant reduction in mPAP and right ventricular size. Although surgical closure of an ASD with severe PAH is a high-risk procedure, it can be safely performed in carefully selected patients with appropriate preoperative evaluation, medical optimization, and careful surgical technique. Timely closure of the defect can result in a considerable improvement in the patient's hemodynamic status and quality of life.
Cardiovasc j 2024; 16(2): 110-113
Entry into A Cardiac Surgery Set Up: The Associated Risks and Difficulties for Inexperienced New Medical Staff
Authors: Nazmul Hosain  , Aniqa Sattar  , Maruf Hassan Alam Arnob  , Md Anisuzzaman  , Chowdhury Md Abdul Quaium 
Published: August 2024

Background: Cardiac Surgery is one of the most sophisticated branches of medical science, which is continually being updated. With very little inclusion in medical course curriculum, medical graduates have limited orientation of this pristine subject. Capacity building is lengthy and cardiac surgery units often contain unrelated junior doctors due to scarcity of cardiac surgeons. New residents may also face similar difficulties. The objectives of this article are to describe the difficulties faces by newly posted doctors and offer some solutions.
Methods: This study was conducted in the Department of Cardiac Surgery, Chittagong Medical College & Hospital (CMCH) between January 2020 and December 2022. A confidential self-report system questionnaire was used to interview 30 newcomers in CMCH and other cardiac surgery set ups and their findings are compiled in the article.
Results: The interviewed doctors and residents have described individualities of cardiac surgery department and the difficulties they faced while working here. They also offered some solutions of the problems faced by them.
Conclusion: Cardiac surgery is a stressful job. The new residents and unrelated doctors face various problems while beginning here. This is more troublesome for the female doctors, but doctors trained in cardiology or other surgical disciplines suffered least. Orientation initiatives by the cardiac surgery department and publishing a complete manual handbook to provide guidelines will be helpful in this regard.
Cardiovasc j 2024; 16(2): 81-85
Chronic systolic heart failure: association of remodeling of the right heart and renal dysfunction with cardiac arrhythmias
Authors: Molchanova Zh. V. , Ivannikov A. A. , Musaeva F. M. , Ivanov D. I. , Kosolapov D. A. , Alidzhanova H. G. 
Published: August 2024

Introduction. Ischemic (ICMP) and dilated cardiomyopathy (DCMP) are the leading causes of chronic heart failure (CHF) with the most frequent indication for heart transplantation. The similarity of these diseases consists in the widespread and high mortality rate due to pathological remodeling of both the left and right chambers of the heart, which is accompanied by the progression of CHF, increasing the risk of sudden cardiac death.The purpose of the study. To study the relationship of systolic function of the left ventricle (LV) with remodeling of the right heart, renal dysfunction and their relationship with cardiac arrhythmia.Materials and methods. The study included 72 patients with CHF with reduced ejection fraction (CHFrEF), who were being treated at the N. V. Sklifosovsky Scientific Research Institute of EM in connection with worsening CHF. Group I consisted of 48 patients with DCMP; group II – 24 patients with ICMP.Results. LV ejection fraction (LV EF) in patients of both groups was <30 %, but it was significantly lower in group I (p=0.001). The EF of the right ventricle (RV) in group I was low and amounted to 24.6 [19.5; 28.5]%. In group I, the volume of the right atrium (PP) and the size of the pancreas correlated with LV EF (r= –0.489, p=0.015 and r= –0.410, p=0.005, respectively); each subsequent increase in the volume of right atrium (RA) by 1 ml increased the likelihood of atrial fibrillation (AF) by 1.018 times (OR: 1.018, 95 % CI: 1.0042–1.033, p=0.011). The estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2 increased the chances of ventricular tachycardia (VT) by 9.5 times (OR: 9.5, 95 % CI: 2.32–38.87, p=0.002). Each subsequent decrease in eGFR by 1 ml/min/1.73 m2 increased the chances of developing VT by 1.03 times (OR: 0.967, 95 % CI: 0.937–0.988, p=0.036)].Conclusions. In patients with CHFrEF, regardless of the etiology, a decrease in LV EF leads to structural and functional changes in the right parts of the heart. In individuals with DCMP, an increase in RA volume by 1 ml increases the likelihood of AF by 1.018 times; a decrease in eGFR by 1 ml/min/1.73 m2 increases the chances of developing VT by 1.03 times.
Genetic associations between gut microbiota and type 2 diabetes mediated by plasma metabolites: a Mendelian randomization study
Authors: Zheng XuWen , Chen MaoBing , Zhuang Yi , Zhao Liang , Qian YongJun , Xu Jin , Fan JinNuo 
Published: August 2024

BackgroundNumerous research studies have indicated a possible association between type 2 diabetes (T2DM) and gut microbiota. To explore specific metabolic pathways connecting gut microbiota and T2DM, we employed Mendelian randomization (MR) and linkage disequilibrium score regression (LDSC) techniques.MethodsThis research utilized data from genome-wide association studies (GWAS) that are publicly accessible. We evaluated the genetic correlation between gut microbiota and T2DM using LDSC. Causality was primarily determined through the inverse variance weighted (IVW) method. To verify the robustness of our results, we conducted sensitivity analyses using several approaches, including the weighted median, MR-Egger, and MR-PRESSO. We integrated summary effect estimates from LDSC, along with forward and reverse MR, into a meta-analysis for T2DM using various data sources. Additionally, mediation analysis was performed to explore the impact of plasma metabolites on the relationship between gut microbiota and T2DM.ResultsOur study indicated a significant genetic correlation between genus RuminococcaceaeUCG005 (Rg = −0.26, Rg_P = 2.07×10−4) and T2DM. Moreover, the forward MR analysis identified genus RuminococcaceaeUCG010 (OR = 0.857, 95% CI 0.795, 0.924; P = 6.33×10−5) and order Clostridiales (OR = 0.936, 95% CI 0.878, 0.997; P = 0.039) as being significantly associated with a decreased risk of T2DM. The analysis also highlighted several plasma metabolites as significant mediators in these relationships, with metabolites like octadecadienedioate (C18:2-DC) and branched chain 14:0 dicarboxylic acid being notably involved.ConclusionThe findings demonstrate a significant impact of gut microbiota on T2DM via plasma metabolites, suggesting potential metabolic pathways for therapeutic targeting. This study enhances our understanding of the microbiota’s role in T2DM pathogenesis and supports the development of microbiota-based interventions.
Wake interference of tandem wind turbines considering pitch strategy based on the AL-LDS-Ωnew coupling method
Authors: Ji Renwei , Kong Ming , Sun Ke , Zhang Jianhua , Zhu Renqing , Yin Minwei , Zhang Yuquan , Fernandez-Rodriguez E. 
Published: August 2024

This paper establishes a high-fidelity and efficient Computational Fluid Dynamics (CFD) numerical method (AL-LDS-Ωnew) for wind turbine wake by combining the actuator line (AL), the localized dynamic Smagorinsky (LDS) sub-grid scale (SGS), and the new generation Ωnew vortex identification method under the framework of large eddy simulation. The model advantages are encouraging: 1) In terms of turbine modeling, the AL model is adopted to replace the traditional three-dimensional solid model, which avoids solving the boundary layer on the blade surface and improves computational efficiency; 2) In terms of wake simulation, the LDS SGS model is used to model turbulence, reducing vortex dissipation and further improving the refinement of turbine wake; 3) In terms of vortex identification, the new generation Ωnew vortex identification method avoids the difficult threshold selection in previous vortex identification and captures more refined vortex structures. The accuracy of the model is validated against published data of a NREL 5 MW wind turbine, and then extended to simulate the wake interference of tandem twin-rotor turbines by changing the pitch angle of the upstream wind turbine (WT1). The influence mechanisms between array wake interference and energy conversion efficiency under the pitch strategy are explored, demonstrating the AL-LDS-Ωnew coupling method is computationally accurate and efficient for simulating the complex wake interference. From analyses, the pitch strategy can effectively suppress the wake effect of the upstream turbine (WT1) and increase the power output of the downstream turbine (WT2), thus improving the overall output power of the array farm. Compared with the non-pitch condition (0 pitch angle), a pitch angle of (2°) maximizes the global energy conversion efficiency of the twin-rotor array: power augmentation by 0.29%, and thrust reduction by 5%. This optimal state reduces the fatigue load of the turbine and is more conducive to long-term operation. The findings, whilst preliminary, encourage the use of turbine pitch strategies in the wind farm planning and operation.
Temporal and spatial characteristics of agricultural non-point source pollution in Hebei Province from 2000 to 2021
Authors: Li Tongtong , Niu Yongchao , Pang Jun , Geng Shuang , Wang Yangyang , Li Ji , Xiong Yanna , Wang Lei 
Published: August 2024

Agricultural non-point source pollution (ANP) had become an important source of water pollution, which seriously restricted the coordinated development of Beijing, Tianjin and Hebei. As the primary agricultural production base in the region of Beijing-Tianjin-Hebei, Hebei had serious ANP. In order to clarify the current status of ANP in Hebei and figure out the main pollution source and areas, ANP load of Hebei from 2000 to 2021 were evaluated by the export coefficient modeling (ECM) and spatial-temporal characteristics were carried out using geographic information system (GIS). In addition, ANP severity and emission characteristics of Hebei in 2021 were evaluated. The results showed that the environmental impact of ANP in southwest area was obviously more serious than that in northeast area of Hebei. Especially, ANP emissions in Hebei showed significant decreasing inflection points in 2007 and 2017, respectively, reaching a minimum by 2021. The TN and TP emissions of ANP in Hebei were 315,026.1 t and 50,323.76 t in 2021, respectively. The contribution of agricultural land, livestock and poultry breeding and rural life to TN and TP emissions were 37%, 34%, 29% and 20%, 61% and 18%, respectively. The ANP pollution mainly came from livestock and poultry breeding in Hebei Province. Based on cluster analysis, cities in Hebei were divided into four types, and the control strategies for ANP environment management were put forward.
Prognostic value of four immune-related genes in lower-grade gliomas: a biomarker discovery study
Authors: Wang Shuowen , Wang Zijun , Liu Zhuo , Wu Jianxin 
Published: August 2024

IntroductionThe tumor microenvironment and IRGs are highly correlated with tumor occurrence, progression, and prognosis. However, their roles in grade II and III gliomas, termed LGGs in this study, remain to be fully elucidated. Our research aims to develop immune-related features for risk stratification and prognosis prediction in LGG.MethodsUsing the ssGSEA method, we assessed the immune characteristics of the LGG population. We conducted differential analysis using LGG samples from the TCGA database and normal samples from GTEx, identifying 412 differentially expressed immune-related genes (DEIRGs). Subsequently, we utilized univariate Cox, LASSO, and multivariate Cox regression analyses to establish both a gene predictive model and a nomogram predictive model.ResultsHere, we found that the ESTIMATE score, immune score and stromal score of high-immunity, high-grade and isocitrate dehydrogenase (IDH) wild-type glioma were higher than those of the corresponding group, and the tumor purity was lower. Higher ESTIMATE scores, stromal scores and immune scores indicated a poor prognosis in patients with LGG. Our four-gene prognostic model demonstrated superior accuracy compared to other molecular features. Validation using the CGGA as a testing set and the combined TCGA and CGGA cohort confirmed its robust prognostic value. Additionally, a nomogram integrating the prognostic model and clinical variables showed enhanced predictive capability.DiscussionOur study highlights the prognostic significance of the identified four DEIRGs (KLRC3, MR1, PDIA2, and RFXAP) in LGG patients. The predictive model and nomogram developed herein offer valuable tools for personalized treatment strategies in LGG. Future research should focus on further validating these findings and exploring the functional roles of these DEIRGs within the LGG tumor microenvironment.