bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolic changes due to dexamethasone premedication in patients with breast cancer.
Authors: Scontre Vanessa Armenio , Lapate Milena Degaspari Gonzales , Testa Laura , Watarai Gabriel , Estevez-Diz Maria Del Pilar 
Published: July 2024

e24127 Background: The treatment for patients diagnosed with breast cancer is based, in the curative intent scenario, on chemotherapy (CT) such as anthracyclines and taxanes. We are aware that some drugs are widely used and necessary before CT administration to avoid unwanted side effects. Dexamethasone is part of the arsenal of these medications, however, pathological conditions resulting from high doses of administration of this corticosteroid are clinically evident in these patients. In this study we aim to evaluate whether omitting a dose of corticosteroid therapy as a premedication after the second week of treatment with taxane can prevent or reduce the incidence of metabolic changes, and its impact on a patient's quality of life (QoL). Methods: A prospective, randomized, open label study. Breast cancer patients with indication for adjuvant or neoadjuvant treatment with doxorubicin, cyclophosphamide and paclitaxel + trastuzumab (AC-T+ TTZ) chemotherapy were randomized to standard arm, with dexamethasone 10 mg IV administered pre-paclitaxel in all cycles and experimental arm, where dexamethasone was omitted from the premedication from the third to the last taxane application. Results: 86 patients were included, 43 patients in each arm. Premedication was administered every cycle and/ or week before the administration of chemotherapy drugs. Patients had lab analysis and QoL EORTC QLQ-C30 before the beginning of the CT, before the third application of Paclitaxel and 24 hours after the last administration. We observed an increase in ACTH in the experimental group, which is predictable since high doses of corticosteroids suppress the hormone pathway; a drop of insulin levels in its levels in the experimental group and stability in its serum levels in the control group; a stability of GH and IGF-1 in the control group and a more pronounced drop in circulating levels of this hormone in the experimental group. The control group had a greater increase in the excretion of aldosterone, probably due water retention caused by the use of dexamethasone. There were no adverse events reported in the experimental group and also hypersensitivity or anaphylactic reactions were not observed. The EORTC-QLQ-C30 scores related to diarrhea, constipation, inappetence and insomnia were better in the experimental group, as well the average score for global health. Conclusions: The omission of dexamethasone in patients in the experimental group improved QOL scores related to common AEs during CT, mainly GI and also insomnia. Insulin levels were also lower in this group. The potential reduction of the incidence of metabolic syndrome seems palusible but would require larger sample size. The short term safety and tolerability of this regimen warrants its use in larger populations. Clinical trial information: NCT04350229 .
A phase 2, open-label, single-arm, prospective, multicenter study of nab-sirolimus plus letrozole in advanced or recurrent endometrioid endometrial cancer.
Authors: Dockery Lauren E. , Slomovitz Brian M. , Musa Fernanda , Mathews Cara Amanda , Priebe Anna M. , Green Angela , Puechl Allison , Birrer Michael J. , Spirtos Nicola M. , Ding Li , Schmid Anita N. , Navarro Willis H. , Moore Kathleen N. 
Published: July 2024

TPS5640 Background: This clinical trial is designed to evaluate the antitumor activity of nab-sirolimus in combination with letrozole in patients with advanced or recurrent endometrioid endometrial carcinoma (EEC). Despite recent pivotal data demonstrating improved outcomes with immunotherapy plus chemotherapy, regardless of mismatch repair status, alternative nonchemotherapy-based treatment options for patients with advanced or recurrent EEC remain necessary. Dysregulation of mTOR signaling is implicated in the pathology of EEC, in which >80% harbor PTEN or PI3K/Akt/mTOR pathway alterations. Moreover, crosstalk between mTOR and estrogen receptor signaling pathways is associated with endocrine therapy resistance. GOG-3007 and other phase 2 studies have demonstrated that the combination of conventional mTOR inhibitors (mTORis) and endocrine therapy provides clinical benefit in patients with EEC. nab-Sirolimus is an mTOR inhibitor that uses albumin-bound sirolimus nanoparticles given by IV and is approved by the US FDA for malignant perivascular epithelioid cell tumor. Preclinical data of nab-sirolimus demonstrated improved tumor accumulation, mTOR inhibition, and tumor growth suppression compared with conventional mTORis. We hypothesize that the simultaneous inhibition of mTOR and ER with nab-sirolimus and letrozole, respectively, may provide a signal of synergistic antitumor activity in patients with recurrent EEC. Methods: In this phase 2, open-label, single-arm, multicenter study (NCT05997017), nab-sirolimus (100 mg/m2, intravenous, on days 1 and 8 of each 21-day cycle) and letrozole (2.5 mg, oral, daily) are administered to patients (~29 planned, Simon’s 2-stage design) with clinically confirmed, advanced, or recurrent EEC. Eligibility criteria include age ≥18 years, ≤1 prior chemotherapy-based regimen in the advanced, metastatic, or recurrent setting, prior adjuvant chemotherapy is permitted, Eastern Cooperative Oncology Group performance status score 0 or 1, naive to mTORi, and measurable disease (per Response Evaluation Criteria in Solid Tumors [RECIST] v1.1). The primary endpoint is best overall response rate by RECIST v1.1. Key secondary endpoints include duration of response, disease control rate (defined as complete response plus partial response plus stable disease of ≥12 weeks after start of treatment), progression-free survival, overall survival, and safety. Exploratory endpoints include correlation of baseline molecular biomarkers with clinical outcomes. The trial is open for enrollment. Clinical trial information: NCT05997017 .
PEMDA-HN, an open-label, phase II, randomized controlled study of danvatirsen plus pembrolizumab compared to pembrolizumab alone in first-line recurrent and/or metastatic head and neck squamous cell carcinoma (RM HNSCC).
Authors: Posner Marshall R. , Wong Deborah J.L. , Harrington Kevin Joseph , O'Neal Richard Lee , Makris Lukas , Perdomini Morgane , MacIntyre Susan , Denker Andrew , Saba Nabil F. 
Published: July 2024

TPS6113 Background: Signal transducer and activator of transcription 3 (STAT3) plays critical roles in promotion of an immune-suppressive tumor microenvironment and survival of tumor cells. Danvatirsen (DANVA) is a 16-nucleotide, generation 2.5 antisense oligonucleotide designed to down-regulate the expression of human STAT3 mRNA. Over 500 patients with hematologic malignancies or solid tumors have been exposed to DANVA monotherapy or in combination. A tolerable safety profile has been demonstrated for DANVA and toxicities are manageable. The SCORES study in recurrent and/or metastatic (RM) HNSCC patients, naïve to programmed cell death (ligand)1 (PD-(L)1) therapy, demonstrated that DANVA in combination with the PD-L1 inhibitory antibody durvalumab administered in the second line setting appeared to result in a higher objective response rate (ORR) (22.6% [12.3-36.2]) compared with the ORRs seen with durvalumab alone in prior studies (Cohen E. et al. Ann. Oncol., 2018). Several patients had complete responses (CR, 9.4%). The ORR was higher in patients with a PD-L1 tumor proportion score (TPS) ≥1 and ≥20, with increasing benefit noted with higher PD-L1 expression compared with historic anti-PD-(L)1 monotherapy data. The current study aims at evaluating the first-line combination of DANVA with pembrolizumab, an anti-PD-1 agent approved as first-line monotherapy for RM HNSCC in patients with PD-L1 positive disease. Methods: PEMDA-HN is a multicenter, open-label, randomized phase 2 study utilizing a Bayesian Optimal design (BOP2). Approximatively 81 RM HNSCC patients with a PD-L1 combined positive score (CPS) score ≥1 will be randomized in a 2:1 ratio stratified based on CPS<20 and CPS≥20 to receive either DANVA (3 mg/kg IV Days 1, 3, and 5 and then weekly starting on Day 8) and pembrolizumab (200 mg IV every 3 weeks) or pembrolizumab alone as a first line therapy for recurrent or metastatic disease. Eligible patients will receive study treatment until disease progression or discontinuation. The primary endpoint of the study is ORR by response evaluation criteria in solid tumors version 1.1 (RECIST 1.1) as assessed by the investigator. Key secondary objectives are safety, additional antitumor activity evaluation (CR rate, duration of response, disease control rate, progression-free and overall survival) and pharmacokinetics. Efficacy (e.g. ORR, CR rate) will be evaluated in all patients and in subsets of patients with CPS<20, CPS≥20 and CPS≥50. Exploratory endpoints include but are not limited to target engagement and biomarker evaluation. The study is being, or will be, conducted at US, South Korea and United-Kingdom study centers. Clinical trial information: NCT05814666 .
Interacting with Man or Machine: When Do Humans Reason Better?
Authors: Bayer Ralph-Christopher , Renou Ludovic 
Published: July 2024

The resolution of complex problems is widely seen as the next challenge for hybrid human–artificial intelligence (AI) teams. This paper uses experiments to assess whether there is a difference in the quality of human reasoning depending on whether the humans interact with humans or algorithms. For this purpose, we design an interactive reasoning task and compare the performance of humans when paired with other humans and AI. Varying the difficulty of the task (i.e., steps of counterfactual reasoning required), we find that, for simple tasks, subjects perform much better if they play with other humans, whereas the opposite is true for difficult problems. Additional experiments in which subjects play with human experts show that the differences are driven by the knowledge that AI reasons correctly rather than that it is nonhuman. This paper was accepted by Elena Katok, special issue on the human-algorithm connection. Supplemental Material: The data files are available at https://doi.org/10.1287/mnsc.2023.03315 .
Effects of metformin on knee joint capsule fibrosis in a diabetic mouse model
Authors: Naito Toichiro , Yamanaka Yoshiaki , Tokuda Kotaro , Sato Naohito , Tajima Takafumi , Tsukamoto Manabu , Suzuki Hitoshi , Kawasaki Makoto , Nakamura Eiichiro , Sakai Akinori 
Published: July 2024

AimsThe antidiabetic agent metformin inhibits fibrosis in various organs. This study aims to elucidate the effects of hyperglycaemia and metformin on knee joint capsule fibrosis in mice.MethodsEight-week-old wild-type (WT) and type 2 diabetic (db/db) mice were divided into four groups without or with metformin treatment (WT met(-/+), Db met(-/+)). Mice received daily intraperitoneal administration of metformin and were killed at 12 and 14 weeks of age. Fibrosis morphology and its related genes and proteins were evaluated. Fibroblasts were extracted from the capsules of 14-week-old mice, and the expression of fibrosis-related genes in response to glucose and metformin was evaluated in vitro.ResultsThe expression of all fibrosis-related genes was higher in Db met(-) than in WT met(-) and was suppressed by metformin. Increased levels of fibrosis-related genes, posterior capsule thickness, and collagen density were observed in the capsules of db/db mice compared with those in WT mice; these effects were suppressed by metformin. Glucose addition increased fibrosis-related gene expression in both groups of mice in vitro. When glucose was added, metformin inhibited the expression of fibrosis-related genes other than cellular communication network factor 2 (Ccn2) in WT mouse cells.ConclusionHyperglycaemia promotes fibrosis in the mouse knee joint capsule, which is inhibited by metformin. These findings can help inform the development of novel strategies for treating knee joint capsule fibrosis.Cite this article: Bone Joint Res 2024;13(7):321–331.
Risks of anxiety disorders, depressive disorders, and sleep disorders in patients with dengue fever: A nationwide, population-based cohort study
Authors: Shih Hsin-I , Wang Yu-Ping , Chi Chia-Yu , Chien Yu-Wen 
Published: July 2024

Background
Dengue virus (DENV) infection, a common mosquito-borne disease, has been linked to several mental disorders like depression and anxiety. However, the temporal risk of these disorders after DENV infection is not well studied.

Methods
This population-based cohort study encompassed 45,334 recently lab-confirmed dengue patients in Taiwan spanning 2002 to 2015, matched at a 1:5 ratio with non-dengue individuals based on age, gender, and residence (n = 226,670). Employing subdistribution hazard regression analysis, we assessed the immediate (<3 months), intermediate (3–12 months), and prolonged (>12 months) risks of anxiety disorders, depressive disorders, and sleep disorders post DENV infection. Corrections for multiple comparisons were carried out using the Benjamini-Hochberg procedure.

Results
A significant increase in depressive disorder risk across all timeframes post-infection was observed (<3 months [aSHR 1.90, 95% CI 1.20–2.99], 3–12 months [aSHR 1.68, 95% CI 1.32–2.14], and >12 months [aSHR 1.14, 95% CI 1.03–1.25]). Sleep disorder risk was higher only during 3–12 months (aSHR 1.55, 95% CI 1.18–2.04). No elevated anxiety disorder risk was found. Subgroup analysis of hospitalized dengue patients showed increased risk of anxiety disorders within 3 months (aSHR 2.14, 95% CI 1.19–3.85) and persistent risk of depressive disorders across all periods. Hospitalized dengue patients also had elevated sleep disorder risk within the first year.

Conclusion
Dengue patients exhibited significantly elevated risks of depressive disorders in both the short and long term. However, dengue’s impact on sleep disorders and anxiety seems to be short-lived. Further research is essential to elucidate the underlying mechanisms.
High prevalence of hepatitis B and HIV among women survivors of sexual violence in South Kivu province, eastern Democratic Republic of Congo
Authors: Basimane Bisimwa Parvine , Koyaweda Giscard Wilfried , Bihehe Masemo Dieudonné , Ayagirwe Rodrigue Balthazar Basengere , Birindwa Ahadi Bwihangane , Bisimwa Patrick Ntagereka , Kikuni Besulani Georges , Kashosi Théophile Mitima , Mugisho Matabishi Cadeau , Mitima Misuka Bienfait , Mukonkole Jean Paulin Mbo , Bisimwa Nachega Jean , Mukwege Mukengere Denis , Komas Narcisse Patrice Joseph 
Published: July 2024

Introduction
Limited data are available on the prevalence rates of hepatitis B and acquired immunodeficiency syndrome (AIDS) among women survivors of sexual violence (WSSV) in South Kivu province, in the eastern part of the Democratic Republic of Congo (DRC), where armed conflicts persist. Here, we aimed to assess the prevalence of these two infections in this vulnerable local population.

Methods
A total of 1002 WSSV, aged from 18 to 70 years old were enrolled from May 2018 to May 2020 at three healthcare facilities (Panzi, Mulamba and Bulenga hospitals), which are called “The One-Stop Centre Care Model" for the management of sexual violence in South Kivu. Blood samples were collected and tested for hepatitis B virus (HBV) and human immunodeficiency virus (HIV) antigens and antibodies using enzyme-linked immunoassay (ELISA) methods. Subsequently, viral load quantification for HBV and HIV were performed using the GeneXpert. Univariate and multivariate logistic regression models were used to assess factors associated with HIV-positive and HBV-positive status.

Results
For HBV, overall prevalence was 8.9% (95% CI; 7.2–10.8%), 32.1% (95% CI; 29.3–35.0%), and 14.5% (95% CI; 12.3–16.8%) for HBsAg, anti-HBc and anti-HBs antibodies, respectively. Among the 89 HBsAg-positive patients, 17 (19.1%) were HBeAg-positive. The median age of individuals with a positive HBsAg test was higher than those with a negative test (median: 40 years (IQR 30–52) compared to 36 years (IQR 24–48)). Risk factors for HBV infection were age (≥35 years) (AOR = 1.83 [1.02–3.32]; p = 0.041), having no schooling (AOR = 4.14 [1.35–12.62]; p = 0.012) or only primary school-level (AOR = 4.88 [1.61–14.75]; p = 0.005), and multiple aggressors (AOR = 1.76 [1.09–2.84], p = 0.019). The prevalence of HIV was 4.3% [95% CI: 3.1–5.7%]. HIV/HBV co-infection occurred only in 5 individuals (0.5%). The HBV viral load was detectable (> 1 log10 UI/mL) in 61.8% of HBsAg-positive subjects and 64.8% HIV-positive subjects had a high viral load (≥ 3 log10 copies/mL).

Conclusion
This study revealed a high prevalence of HBV and HIV infections among WSSV in South Kivu. The results generated highlight the urgent need for systematic screening of HBV and HIV by integrating fourth-generation ELISA tests in HIV and HBV control programs.
‘Other Stations Are Shit’: Student Radio in Aotearoa New Zealand, Matt Mollgaard and Karen Neill (2023)
Authors: Fauteux Brian 
Published: July 2024

Review of: ‘Other Stations Are Shit’: Student Radio in Aotearoa New Zealand, Matt Mollgaard and Karen Neill (2023)
Christchurch: Freerange Press, 228 pp.,
ISBN 978-0-47369-263-6, e-book, $24.45

Live from the Underground: A History of College Radio, Katherine Rye Jewell (2023)
Chapel Hill, NC: The University of North Carolina Press, 480 pp.,
ISBN 978-1-469677-25-5, p/bk, $29.95
Hydraulic Dynamics of the Riparian Soil in the Chapadão do Diamante - Serra da Canastra, Minas Gerais
Authors: Confessor Jefferson Gomes , Silva Lara Luiza , Lima Natália Aparecida Rodrigues , Santos Anna Beatriz Pereira dos 
Published: July 2024

Serra da Canastra National Park, located in the Cerrado Biome in the State of Minas Gerais, Brazil, consolidates a conservation unit that includes the sources of several important Brazilian hydrographic basins. Given the significance of local and national water supply and regulation, this study aimed to analyze and understand the physical-hydraulic characteristics of the soil in the riparian zone within the park. Field data were collected using a rainfall simulator and a concentric ring infiltrometer. The results demonstrated an elevated infiltration capacity in the study área. Only 23.74% of the 57.4mm of artificially precipitated high-intensity rainfall was runoff. Basic infiltration velocity (BIV) values were considered very high (50.74 mm/h). Overall, these values were associated with the characteristics of the landscape, highlighting the importance of vegetation in the soil cover and the physical attributes of the soil. These factors influenced the modulation of the soil's capacity to retain, infiltrate, and store large volumes of water. In this regard, the importance of these riparian zones for the environment was emphasized as they play a crucial role in protecting watercourses. They act as barriers against erosive flow from upstream areas, incorporating water into the soil profile to store and release over time. These areas thus become important sites for water regulation.
Toponymic unity of the Carpathian region
Authors: Oczko Anna 
Published: July 2024

Abstract
The article lists 26 toponyms that are characteristic and common in the entire Carpathian region. They have been selected according to their toponymic classification (mostly oronyms, hydronyms, and oikonyms), and their etymology. These toponyms are commonly observed in the parts of the Carpathian Mountains located in Czech Republic, Poland, Romania, Slovakia, and Ukraine. As the basis for the toponymic analysis, we accepted a common appellative of Romanian or Slavic origins. Migrations of peoples of Slavic and Romanian (Vlach) origin had a significant influence on the dissemination of these toponyms, mainly due to pastoral transhumance and the so-called Vlach colonization. The toponyms were analyzed in semantic and structural terms. The list presents a variety and richness of regional forms which may be encountered in different Carpathian dialects as a legacy of ancient language contacts.
Potenzialorientierung – Skizzierung eines zukunftsfähigen Ansatzes zur Förderung des schulischen Fremd- und Zweitsprachenlernens
Authors: Aguado Karin , Schiffel Holger , Schlaak Claudia 
Published: July 2024

Zusammenfassung
Während das Konzept der Inklusion vielfach Beeinträchtigungen und Defizite fokussiert, betont das Konzept der Potenzialorientierung eher die Ressourcen und die Stärken von Lernenden. Im Anschluss an die Klärung zentraler Begrifflichkeiten und Ansätze, die für die Potenzialorientierung grundlegend sind, wird die Bedeutung dieses Ansatzes für einen zeitgemäßen kompetenzorientierten Fremd- und Zweitsprachenunterricht umrissen sowie seine Rolle bei der Bewältigung aktueller bildungspolitischer und gesamtgesellschaftlicher Herausforderungen skizziert.
Individualisierung bei Schülerinnen und Schülern mit Deutsch als Zweitsprache (DaZ) – Umsetzung von Potenzial-orientierung am Übergang in den Regelunterricht
Authors: Michalak Magdalena , Ulrich Kirstin 
Published: July 2024

Zusammenfassung
Der Beitrag untersucht am Beispiel der Daten aus der Studie ForEST (Formative Evaluation von SPRINT) (Michalak/Lotter/Winter 2023), welche Möglichkeiten für individualisiertes Lernen in der Arbeit mit neu zugewanderten Schülerinnen und Schülern der Sekundarstufe I im DaZ-Unterricht und am Übergang in den Regelunterricht aufgegriffen werden. Hierfür werden Gruppendiskussionen (n=139) mit Realschullehrkräften inhaltsanalytisch ausgewertet. Die Ergebnisse zeigen, dass die Offenheit eines Förderkonzeptes für die Ausgestaltung der individualisierten Zugänge wesentlich ist.
Potenzial und Inklusion sehbeeinträchtigter Lernender im DaF-Unterricht mit Fokus auf der Förderung der Lesekompetenz
Authors: Polizio Daniele , Szabó Erzsébet 
Published: July 2024

Zusammenfassung
Lernende mit Sehbeeinträchtigung waren bisher selten Gegenstand der Fremdsprachen- bzw. DaF-Forschung. In der vorliegenden Interviewstudie wird aus der Perspektive von drei blinden DaF-Lernerinnen deren Potenzial im Regelunterricht mit besonderem Bezug auf die Fertigkeit Lesen beleuchtet. Fokussiert werden dabei die Motivation zum Deutschlernen, Lern- und Leseprozesse sowie die Rolle von Lehrpersonen und Mitlernenden in Klassen mit Sehbeeinträchtigten.
Un instante indómito
Authors: Ferrari Ludmila 
Published: July 2024

The essay follows the trail of the “white column,” an architectural expression of the sovereign will to give a definitive form to the national identity, tracing its trajectory from the construction of Brasília (1956) to the Castello Branco dictatorship (1970). The essay explores the processes of formation (Didi-Huberman) and deformation of such communitarian architectonics and regards Brasília not as the monumental co-substantiation of national identity (as proposed by modernist/populist rhetoric), but as an example of a deferred modernity. The article explores the relationship between architecture and sovereignty using différance as a movement of inquiry and the white column as a body of analysis. This is an attempt, in short, to think through the historical and conceptual relations between architecture, labor and race.
The text is divided into three sections, each comprising a certain phantasmagoria of the white column, understood as the unfinished formation of modernity. In the first part, the theoretical components required to identify the formations that connect the extractive system of the sugar cane engenho with the new monumentality of Brasília are presented. Focusing on the colonnade designed by Niemeyer for the Palácio da Alvorada, the second part analyzes the relationship between suspension tectonics and the 1964 coup d’état. The last part investigates the playful reformulation of the white column in Ernesto Neto’s Leviathan Thot and its deject exploration, together with visual artist Artur Barrio’s trouxas ensangrentadas.