bluuebunny/crossref_metadata_2025_split huggingface dataset:
Network-coded primary-secondary cooperation in OFDM-based cognitive multicast networks
Authors: Liu Zhihui , Xu Wenjun , Li Shengyu , Lin Jiaru 
Published: May 2015

Abstract
This paper investigates resource allocation for network-coded primary-secondary cooperation in orthogonal frequency division multiplexing (OFDM)-based cognitive multicast networks, in which cognitive radio (CR), network coding (NC), multicast, and OFDM are effectively combined toward the spectrum efficient fifth generation (5G) wireless communication systems. Different from the conventional one-to-one/one-to-more primary-secondary cooperation, the paper concentrates on two-to-one primary-secondary cooperation, in which one secondary user (SU) cooperates with two primary users (PUs) to gain more spectrum access opportunities. To accomplish the cooperation, an agreement is established between the SU and PUs. Meanwhile, to alleviate spectrum bands consumed for PUs’ data transmission, network coding is employed at the SU transmitter. Subject to per-primary-user minimum rate requirement and the total power budget at the secondary transmitter, the investigated primary-secondary cooperation strategy is formulated as a mixed integer optimization problem with the aim of maximizing the average multicast transmission rate. The formulated problem is non-convex and difficult to solve directly. In this paper, a stepwise optimization algorithm is proposed in which the subcarrier assignment and power allocation are executed separately to reduce the computation complexity. The simulation results show that compared to existing schemes, the achieved secondary multicast transmission rate in the proposed scheme is greatly improved. The presented network-coded primary-secondary cooperation is a promising paradigm to improve the spectrum efficiency for the future 5G systems.
Conservation oriented habitat classification scheming and mapping of Egypt
Authors: Harhash Khaled Allam , El-Henawy Mohmmed Talaat , Fattah Haitham Farouk Abdel , Antar Mohammed Sameh 
Published: May 2015

Abstract

Background
“habitat classification models” are invaluable tools for species conservation, land-use planning, reserve design, and meta-population assessments, particularly at broad spatial scales”. Globally, there are at least 23 schemes developed for habitat classification schemes. The pioneer attempts in Egypt for classifying habitats were started by the series of Kassas giving a concern about dry lands and desertification problems. The main purpose of this paper is to: 1) present a suitable model for large scale planning to support the decision making process towards the natural resources in Egypt, 2) standardize data collection on habitats which will assist in management and conservation of the Egypt’s natural heritage.

Results
This paper presents new GIS-based habitat classification hierarchy that contains 5 main habitat systems, 12 habitat sub-system and 36 habitat classes. One of the major outputs of this present scheme is to define the boundaries of the three classes (epipelagic – mesopelagic – bathypelagic) of the pelagic sub-system.

Conclusion
This hierarchy represents a new GIS-based standardized habitats scheming for Egypt. It was designed to support the current efforts to define the key biodiversity hotspots as well as long term planning of biodiversity at the national level. This new habitat mapping/scheming, has considerable potential utility for conservation priority setting for Egypt; it could be used to design and update the existing protected areas network; it could be used to evaluate the protected areas system representativeness, and climate change impacts studies. It is recommended to link habitat classification and mapping efforts in Egypt to regional and global approaches.
Study of phosphorylation events for cancer diagnoses and treatment
Authors: López Villar Elena , Madero Luis , A López‐Pascual Juan , C Cho William 
Published: May 2015

AbstractThe activation of signaling cascades in response to extracellular and intracellular stimuli to control cell growth, proliferation and survival, is orchestrated by protein kinases via phosphorylation. A critical issue is the study of the mechanisms of cancer cells for the development of more effective drugs. With the application of the new proteomic technologies, together with the advancement in the sequencing of the human proteome, patients will therefore be benefited by the discovery of novel therapeutic and/or diagnostic protein targets. Furthermore, the advances in proteomic approaches and the Human Proteome Organization (HUPO) have opened a new door which is helpful in the identification of patients at risk and towards improving current therapies. Modification of the signaling‐networks via mutations or abnormal protein expression underlies the cause or consequence of many diseases including cancer. Resulting data is used to reveal connections between genes proteins and compounds and the related molecular pathways for underlining disease states. As a delegate of HUPO, for human proteome on children assays and studies, we, at Hospital Universitario Niño Jesús, are seeking to support the human proteome in this context. Clinical goals have to be clearly established and proteomics experts have to set up the appropriate proteomic strategy, which coupled to bioinformatics will make it possible to achieve new therapies for patients with poor prognosis. We envision to combine our up‐coming data to the HUPO organization in order to support international efforts to advance the cure of cancer disease.
Investigation of the high-frequency wavefield of an off-center monopole acoustic logging-while-drilling tool
Authors: Wang Hua , Tao Guo , Fehler Michael C. 
Published: May 2015

During logging-while-drilling (LWD) operations, complex drill string movements and the weight of the drill pipe often lead to a measurement tool that is not centralized. Therefore, studies of the response of an off-center acoustic LWD tool are essential to facilitate better interpretation of measurements made in an actual drilling environment. Such studies will be helpful for tool design and data processing. We used a finite-difference method to simulate the response of a noncentralized monopole acoustic LWD tool at high frequency (10 kHz). We analyzed the effects on the waveforms for receivers at different azimuths caused by an off-center tool with differing amounts of offset. We used velocity-time semblance and dispersion analysis methods to help us to understand the modes in the waveforms at different azimuth receivers for different tool offsets. We have found that the waveforms in the direction of the tool offset, that is, where the fluid column is smallest, were affected the most. Waveforms in the orthogonal direction were less affected by tool offset. Collar flexural and collar quadrupole modes appear when the tool is off center. In addition, the formation flexural and quadrupole modes contaminate the Stoneley wave. Waveforms in a fast formation are more strongly affected by the offset of the tool than those in a slow formation. In a fast formation, the new collar modes make it difficult to determine the P-wave velocity in the direction of tool offset whereas it is easier in the orthogonal direction. However, P-waves are less contaminated by new modes in a slow formation. Due to the significant changes in waveforms with azimuth when the tool is off center, the simple addition of all waveforms from an azimuthal distribution of receivers will not result in a clean waveform that is sensitive to only the surrounding formation.
Akt-mediated phosphorylation increases the binding affinity of hTERT for importin α to promote nuclear translocation
Authors: Jeong Sun Ah , Kim Kuglae , Lee Ji Hoon , Cha Jeong Seok , Khadka Prabhat , Cho Hyun-Soo , Chung In Kwon 
Published: May 2015

ABSTRACT
Telomeres are essential for chromosome integrity and protection, and their maintenance requires the ribonucleoprotein enzyme telomerase. Previously, we have shown that human telomerase reverse transcriptase (hTERT) contains a bipartite nuclear localization signal (NLS; residues 222–240) that is responsible for nuclear import, and that Akt-mediated phosphorylation of residue S227 is important for efficient nuclear import of hTERT. Here, we show that hTERT binds to importin-α proteins through the bipartite NLS and that this heterodimer then forms a complex with importin-β proteins to interact with the nuclear pore complex. Depletion of individual importin-α proteins results in a failure of hTERT nuclear import, and the resulting cytoplasmic hTERT is degraded by ubiquitin-dependent proteolysis. Crystallographic analysis reveals that the bipartite NLS interacts with both the major and minor sites of importin-α proteins. We also show that Akt-mediated phosphorylation of S227 increases the binding affinity for importin-α proteins and promotes nuclear import of hTERT, thereby resulting in increased telomerase activity. These data provide details of a binding mechanism that enables hTERT to interact with the nuclear import receptors and of the control of the dynamic nuclear transport of hTERT through phosphorylation.
A high-content screening microscopy approach to dissect the role of Rab proteins in Golgi-to-ER retrograde trafficking
Authors: Galea George , Bexiga Mariana G. , Panarella Angela , O'Neill Elaine D. , Simpson Jeremy C. 
Published: May 2015

ABSTRACT
Here, we describe a high-content microscopy-based screen that allowed us to systematically assess and rank proteins involved in Golgi-to-endoplasmic reticulum (ER) retrograde transport in mammalian cells. Using a cell line stably expressing a GFP-tagged Golgi enzyme, we used brefeldin A treatment to stimulate the production of Golgi-to-ER carriers and then quantitatively analysed populations of cells for changes in this trafficking event. Systematic RNA interference (RNAi)-based depletion of 58 Rab GTPase proteins and 12 Rab accessory proteins of the PRAF, YIPF and YIF protein families revealed that nine of these were strong regulators. In addition to demonstrating roles for Rab1a, Rab1b, Rab2a, and Rab6a or Rab6a′ in this transport step, we also identified Rab10 and Rab11a as playing a role and being physically present on a proportion of the Golgi-to-ER tubular intermediates. Combinatorial depletions of Rab proteins also revealed previously undescribed functional co-operation and physical co-occurrence between several Rab proteins. Our approach therefore provides a novel and robust strategy for a more complete investigation of the molecular components required to regulate Golgi-to-ER transport in mammalian cells.
Neutrophil Lymphocyte Ratio as a predictor of systemic inflammation - A cross-sectional study in a pre-admission setting.
Authors: Venkatraghavan Lashmi , Tan Tze Ping , Mehta Jigesh , Arekapudi Anil , Govindarajulu Arun , Siu Eric 
Published: May 2015

Background: Neutrophil:lymphocyte ratio (NLR) is an emerging biomarker that is used to predict postoperative mortality and morbidity in cardiac and cancer surgeries. The association of this biomarker with systemic illness and its usefulness in risk assessment of preoperative patients has not been fully elucidated.Objectives: To determine the prevalence of elevated NLR in preoperative patients and to examine the relationship between elevated NLR and the presence of systemic illnesses as well as anaesthesia risk indices such as American Society of Anesthesia (ASA) and the revised cardiac risk index (RCRI) scores. Design: Cross-sectional studySetting: Anaesthesia pre-admission clinic, Toronto Western Hospital, Toronto, CanadaPatients: We evaluated 1117 pre-operative patients seen at an anesthesia preadmission clinic.Results: NLR was elevated (>3.3) in 26.6% of target population. In multivariate analysis, congestive cardiac failure, diabetes mellitus and malignancy were independent risk factors predicting raised NLR. After regression analysis, a relationship between NLR and ASA score (Odds Ratio 1.78; 95% CI: 1.42-2.24) and revised cardiac risk index (RCRI, odds ratio 1.33; 95% CI: 1.09-1.64, p-value: 0.0063) was observed.Conclusions: NLR was elevated (> 3.3) in 26.6% of patients. Congestive cardiac failure and malignancy were two constant predictors of elevated NLR at >3.3 and > 4.5. There was a strong association between NLR and anesthesia risk scoring tools of ASA and RCRI.
The potential of novel native plant materials for the restoration of novel ecosystems
Authors: Jones T.A. , Monaco T.A. , Rigby C.W. 
Published: May 2015

AbstractExtensive ecological change has been sustained by many dryland ecosystems throughout the world, resulting in conversion to so-called novel ecosystems. It is within such ecological contexts that native plant materials destined for ecological applications must be able to function. In the Wyoming big sagebrush (Artemisia tridentata Nutt. ssp. wyomingensis [Beetle & A.M. Young] S.L. Welsh) ecosystems of the Intermountain West, for example, novel ecosystem structure and functioning are pervasive. Invasive species, particularly annual grasses, fuel repeated wildfires that drive previously stable ecosystem states across thresholds to less desirable states that are highly recalcitrant to restoration efforts. Structural changes include reductions of native flora, damage to biological soil crusts, and alterations to soil microbiota. Functional changes include altered hydrologic and nutrient cycling, leading to permanent losses of soil organic matter and nitrogen that favor the invaders. We argue that there is an important place in restoration for plant materials that are novel and/or non-local that have been developed to be more effective in the novel ecosystems for which they are intended, thus qualifying them as “ecologically appropriate.” Such plant materials may be considered as an alternative to natural/local “genetically appropriate” plant materials, which are sometimes deemed best adapted due to vetting by historical evolutionary processes.
Journalism’s practitioners and the academy: Must they eternally live in different universes?
Authors: Marsh Kevin 
Published: May 2015

Abstract
Journalism and the media have a direct impact for both good and ill on the health of the public discourse, yet practitioners and the academy are as divided as were late medieval barber surgeons from those who studied the relationship between practice and the health of patients. There are both valid and invalid reasons for this – the valid reasons derive from the simple fact journalists and scholars have different roles in the public sphere; and the invalid reasons derive from stubbornness bordering on arrogance on both sides of the divide. Few practitioners see the academy as relevant to them; few accept the need to listen to, understand and perhaps act on informed critique. Few scholars are either prepared to make their work timely and relevant to current issues or to abandon the intimidating formats and incomprehensible language that alienates practitioners. Yet there are numerous examples, including the Public Journalism movement in the United States, the Reuters Institute in Oxford and even the BBC’s review system that demonstrate how practitioners and scholars can be persuaded to inhabit – even briefly – the same universe.
Media convergence practices and production in Ghana and Nigeria: Implications for democracy and research in Africa
Authors: Fosu Modestus , Akpojivi Ufuoma 
Published: May 2015

Abstract
In this era of globalization, information accessibility is becoming crucial to empower citizens in their political, economic and sociocultural engagements. In emerging democracies, economic, cultural and political factors have hindered and still hinder the vast majority of the population from inclusion in the media and democratic discourse. Nevertheless, a ‘new’ phenomenon of media convergence is evolving in emerging democracies like Ghana and Nigeria that appears to provide platforms for wide citizen participation in the political and social discourse. From a phenomenological and exploratory perspective, this paper presents an overview of the media convergence practices in newsrooms in Ghana and Nigeria and their potential impact on the countries’ democracy. The article, on the one hand, juxtaposes this new trend against the need for the media to play a crucial role in sustaining and developing democracy in such countries, and on the other hand it opens discussions and research enquiry into the practices and genre underlying such media productions.
Nalp Signalling is Required in Sertoli Cells for Tight-Junction Protein Interaction
Authors: Hayrabedyan S. , Todorova K. 
Published: May 2015

Summary
The present study aims to investigate the NALP3 system and its influence on occludin in Sertoli cells, utilising primary murine cells and adult Sertoli cell line as models. Its main goals are the Sertoli cell biology with possible implications on male reproductive functions. Primary and adult Sertoli cells were transfected with NAPL3 siRNA and treated with NOD1 (ie-DAP) and NOD2 (MDP) receptor ligands. There was positive occludin expression levels on transcript (RT-qPCR) and protein (FCS and Immunofluorescence) levels for both cell types. The innate immunity and tight-junction pathways integration serve a protective role for both testis immune barrier and spermatogenesis compartmentalisation maintained by the very same barrier. This integration also points the way for mechanistic research of the disturbances inflicted during an inflammatory response in testis niche.
Onychomycosis and Children – A Multicenter Study
Authors: Zisova L. , Chokoeva A. , Sotiriou E. , Valtchev V. , Gospodinov D. 
Published: May 2015

Summary
Onychomycosis is a chronic disease caused by dermatophytes, yeasts and molds, which leads to destruction of the nail plate of the fingernails and toenails. The incidence of onychomycosis in children is considerably smaller compared with that in adults. Onychomycosis in children under 6 years of age is particularly unusual. The trauma and the hyperhidrosis after puberty are the major predisposing factor for fungal nail infection in childhood. Some systemic diseases and congenital syndromes have a crucial role for the development of onychomycosis in children. Wearing infected socks and shoes of other family members, family history for fungal infection of the nails, reduced hygiene and onychophagia are other important predisposing factors. Dermatophytic species Trichophyton rubrum, Trichophyton mentagrophytes and Epidermophyton flocosum are the most frequent causative agents of onychomycosis in adults and much less common yeast of the genus Candida. A retrospective study for a period of 11 years was performed (2003-2013) investigating 292 children aged 0 to 18 years with proven onychomycosis (123 - from Plovdiv, Bulgaria, 94 - from Pleven, Bulgaria, and 75 - from Thessaloniki, Greece). Candida albicans was the main etiologic agent in onychomycosis in children under 18 years of age, according to the performed retrospective study. The diagnose was made by direct microscopic examination and fungal culture on Sabouraud agar media.
Combined Surgical Treatment of Gynecomastia
Authors: Yordanov Y. , Lasso J. M. , Shef A. 
Published: May 2015

Summary
Surgical treatment of gynecomastia could present unique challenges for the plastic surgeon. Achieving a good balance between effectiveness of the selected approach and the satisfactory aesthetic outcome often is a difficult endeavor. Optimal surgical treatment involves a combination of liposuction and direct excision. In the present study the charts of 11 patients treated with suction-assisted liposuction and direct surgical excision were retrospectively reviewed; a special emphasis is placed on the surgical technique. The mean follow-up period of the patients was 11.6 months. No infection, hematoma, nipple-areola complex necrosis and nipple retraction was encountered in this series. The combined surgical treatment of gynecomastia has shown to be a reliable technique in both small and moderate breast enlargement including those with skin excess.
Analysis of Chronic Temporomandibular Disorders Based on the Latest Diagnostic Criteria
Authors: Svechtarov V. , Nencheva-Svechtarova S. , Uzunov Ts. 
Published: May 2015

Summary
The objective of this study is to analyze the distribution of the most common diagnoses observed in patients with chronic temporomandibular disorders, based on the new diagnostic criteria (DC/TMD) adopted in 2014. The previous Research Diagnostic Criteria (RDC/TMD) adopted in 1992, consisted of three main groups of eight diagnostic subgroups and is currently transformed into two main groups and twelve subgroups, respectively. All subgroups correspond to the nomenclature of the ICD-10. The new clinical diagnostic indices are also modified. The analysis showed a prevalence of Pain-Related TMD compared with that of intra-articular disorders in ratio 57.89% to 42.10%. In Pain-Related TMD arthralgia was represented in 55% of cases; local myalgia - in 12%, myofascial pain - in 18%, myofascial pain with referral - in 14%, headache attributed to TMD - in 1%. In Intra-articular TMD disc displacement with reduction was found in 23% of the cases, disc displacement with reduction with intermittent locking - in 3%, disc displacement without reduction with limited opening - in 25%, disc displacement without reduction and without limited opening - in 8%. Degenerative diseases were found in 14.28%, and hypermobility and subluxations - in 26.98%. These analyzes differ and can only partly be compared with previous analyzes based on RDC system. The changes in the diagnostic criteria require new clinical studies in order to refine the picture of temporomandibular pathology in accordance with the modern views on the matter.
Medical Rehabilitation and Occupational Therapy in Patients with Lesion of Plexus Brachialis
Authors: Vacheva D. 
Published: May 2015

Summary
Causes for plexus brachialis damage are versatile, and in some cases remain unknown, but mostly result from degenerative and inflammatory processes. Treatment of brachial plexus dysfunction is often conservative and is subject to a team of specialists - neurologists, traumatologists, rehabilitation physicians, kinesitherapists and occupational therapists. The objective of the research is to report the recovery of patients with lesion of plexus brachialis after a complex physiotherapy and rehabilitation treatment program that includes electrostimulation, remedial massage, kinesitherapy, electrotherapy and occupational therapy. A total of 159 patients, treated at the Clinic of Physical Therapy, University Hospital of Pleven, were included in the study. Improvement of measured indexes: pain assessment, centimetry, assessment of upper limb muscle weakness, dynamometry and functional test of activities of daily living, was registered in all patients under observation. In order to achieve good results in the rehabilitation of patients with injured plexus brachialis, timely diagnosis, good medication therapy and early start of complex physiotherapy and rehabilitation are of crucial importance, so that performance of daily living activities improves. The good results come slowly and with difficulties, but the quality of life of patients and the quality of labor performed by them, improves significantly.