bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGARUH BRAND EXPERIENCE DAN BRAND IMAGE TERHADAP KEINGINAN KONSUMEN UNTUK MEMBAYAR HARGA PREMIUM PADA PEMBELI IPHONE DI WILAYAH JAWA TIMUR
Authors: Putri Dwi , Pratiwi Ni Made Ida , Mulyati Awin 
Published: July 2024

Masyarakat rela untuk mengeluarkan uang lebih untuk suatu produk yang lebih mahal dikarenakan produk tersebut sedang tren di kalangannya. Perkembangan industri teknologi serta adanya perilaku konsumtif yang dimiliki masyarakat Indonesia memicu adanya persaingan dalam dunia usaha. Masing-masing pelaku usaha mencoba untuk bersaing melalui strategi-strategi pemasaran perusahaan dan juga kualitas dari produk yang ditawarkan. Penelitian berjudul "Pengaruh Brand Experience dan Brand Image Terhadap Keinginan Konsumen untuk Membayar Harga Premium pada Pembeli iPhone di Wilayah Jawa Timur" bertujuan untuk memberikan wawasan yang berharga tentang bagaimana Brand Experience dan Brand Image memengaruhi keinginan konsumen untuk membayar harga premium pada pembeli iPhone di wilayah Jawa Timur. Penelitian ini menggunakan metode kuantitatif dengan data primer yang dikumpulkan melalui survei kepada 100 responden di Jawa Timur. Teknik analisis data yang digunakan adalah regresi linier berganda. Hasil penelitian menunjukkan bahwa Brand Experience dan Brand Image secara simultan (bersama-sama) berpengaruh positif terhadap Keinginan Konsumen Membayar Harga Premium pada pembeli iPhone di Wilayah Jawa Timur. Dari hasil uji t (parsial), hasil dari kedua variabel terikat yang paling dominan mempengaruhi dengan nilai paling tinggi adalah Brand Image. Hal ini karena Brand Image mencerminkan persepsi konsumen terhadap kualitas, prestise, dan kepercayaan yang dibangun oleh merek iPhone, yang secara signifikan mendorong keputusan konsumen untuk membayar harga lebih tinggi dibandingkan dengan Brand Experience, yang lebih berfokus pada pengalaman pribadi konsumen dengan produk.
Formación continua sobre infancia en situación vulnerable: necesidades y preferencias en profesionales
Authors: González Caparrós Alicia , Bas Peña Encarnación 
Published: July 2024

La formación continua a profesionales se muestra como un reto por la necesidad de mantener actualizadas a las personas en un entorno en constante evolución. Este reto toma un cariz de mayor envergadura cuando se trata de infancia en situación de vulnerabilidad, porque afecta a sus derechos y es ineludible cumplir los tratados internacionales ratificados por España, así como la normativa estatal y autonómica específica. El texto que presentamos forma parte de una investigación más amplia, relacionada con el estudio de necesidades y preferencias del colectivo de profesionales, de diferentes entidades del tercer sector de acción social (fundaciones, asociaciones, cooperativas, etc.), que desarrollan el Programa CaixaProinfancia en la Región de Murcia (RM). El método empleado, de enfoque cuantitativo, fue la consulta a profesionales que desarrollaban el PCPI, una investigación no experimental, descriptiva o exploratoria, de tipo encuesta, con un marco teórico basado en el enfoque de derechos humanos. En la encuesta participaron 224 profesionales, que formaban parte del PCPI en la RM, durante el curso 2019-2020. Los resultados evidenciaron las carencias formativas de este colectivo profesional en el conocimiento de las situaciones de riesgo para la infancia, legislación vinculada y protocolo autonómico. Se concluye en la urgente necesidad de articular planes de formación continua, que integren contenidos específicos, teóricos y prácticos, sobre estas cuestiones, a fin de que todas las personas vinculadas profesionalmente al citado programa tengan la capacidad de saber detectar situaciones de riesgo para la infancia, así como el protocolo regional a seguir, en su caso.
Anti-inflammatory therapy with nebulized dornase alfa for severe COVID-19 pneumonia: a randomized unblinded trial
Authors: Porter Joanna C , Inshaw Jamie , Solis Vincente Joel , Denneny Emma , Evans Rebecca , Temkin Mia I , De Vasconcelos Nathalia , Aramburu Iker Valle , Hoving Dennis , Basire Donna , Crissell Tracey , Guinto Jesusa , Webb Alison , Esmail Hanif , Johnston Victoria , Last Anna , Rampling Thomas , Lippert Lena , Helbig Elisa Theresa , Kurth Florian , Williams Bryan , Flynn Aiden , Lukey Pauline T , Birault Veronique , Papayannopoulos Venizelos 
Published: July 2024

Background:Prinflammatory extracellular chromatin from neutrophil extracellular traps (NETs) and other cellular sources is found in COVID-19 patients and may promote pathology. We determined whether pulmonary administration of the endonuclease dornase alfa reduced systemic inflammation by clearing extracellular chromatin.Methods:Eligible patients were randomized (3:1) to the best available care including dexamethasone (R-BAC) or to BAC with twice-daily nebulized dornase alfa (R-BAC + DA) for seven days or until discharge. A 2:1 ratio of matched contemporary controls (CC-BAC) provided additional comparators. The primary endpoint was the improvement in C-reactive protein (CRP) over time, analyzed using a repeated-measures mixed model, adjusted for baseline factors.Results:We recruited 39 evaluable participants: 30 randomized to dornase alfa (R-BAC +DA), 9 randomized to BAC (R-BAC), and included 60 CC-BAC participants. Dornase alfa was well tolerated and reduced CRP by 33% compared to the combined BAC groups (T-BAC). Least squares (LS) mean post-dexamethasone CRP fell from 101.9 mg/L to 23.23 mg/L in R-BAC +DA participants versus a 99.5 mg/L to 34.82 mg/L reduction in the T-BAC group at 7 days; p=0.01. The anti-inflammatory effect of dornase alfa was further confirmed with subgroup and sensitivity analyses on randomised participants only, mitigating potential biases associated with the use of CC-BAC participants. Dornase alfa increased live discharge rates by 63% (HR 1.63, 95% CI 1.01–2.61, p=0.03), increased lymphocyte counts (LS mean: 1.08 vs 0.87, p=0.02) and reduced circulating cf-DNA and the coagulopathy marker D-dimer (LS mean: 570.78 vs 1656.96 μg/mL, p=0.004).Conclusions:Dornase alfa reduces pathogenic inflammation in COVID-19 pneumonia, demonstrating the benefit of cost-effective therapies that target extracellular chromatin.Funding:LifeArc, Breathing Matters, The Francis Crick Institute (CRUK, Medical Research Council, Wellcome Trust).Clinical trial number:NCT04359654.
Nuclear magnetic resonance-based metabolomics with machine learning for predicting progression from prediabetes to diabetes
Authors: Li Jiang , Yu Yuefeng , Sun Ying , Fu Yanqi , Shen Wenqi , Cai Lingli , Tan Xiao , Cai Yan , Wang Ningjian , Lu Yingli , Wang Bin 
Published: July 2024

Background:Identification of individuals with prediabetes who are at high risk of developing diabetes allows for precise interventions. We aimed to determine the role of nuclear magnetic resonance (NMR)-based metabolomic signature in predicting the progression from prediabetes to diabetes.Methods:This prospective study included 13,489 participants with prediabetes who had metabolomic data from the UK Biobank. Circulating metabolites were quantified via NMR spectroscopy. Cox proportional hazard (CPH) models were performed to estimate the associations between metabolites and diabetes risk. Supporting vector machine, random forest, and extreme gradient boosting were used to select the optimal metabolite panel for prediction. CPH and random survival forest (RSF) models were utilized to validate the predictive ability of the metabolites.Results:During a median follow-up of 13.6 years, 2525 participants developed diabetes. After adjusting for covariates, 94 of 168 metabolites were associated with risk of progression to diabetes. A panel of nine metabolites, selected by all three machine-learning algorithms, was found to significantly improve diabetes risk prediction beyond conventional risk factors in the CPH model (area under the receiver-operating characteristic curve, 1 year: 0.823 for risk factors + metabolites vs 0.759 for risk factors, 5 years: 0.830 vs 0.798, 10 years: 0.801 vs 0.776, all p < 0.05). Similar results were observed from the RSF model. Categorization of participants according to the predicted value thresholds revealed distinct cumulative risk of diabetes.Conclusions:Our study lends support for use of the metabolite markers to help determine individuals with prediabetes who are at high risk of progressing to diabetes and inform targeted and efficient interventions.Funding:Shanghai Municipal Health Commission (2022XD017). Innovative Research Team of High-level Local Universities in Shanghai (SHSMU-ZDCX20212501). Shanghai Municipal Human Resources and Social Security Bureau (2020074). Clinical Research Plan of Shanghai Hospital Development Center (SHDC2020CR4006). Science and Technology Commission of Shanghai Municipality (22015810500).
Perception and Acceptance of Human Papilloma Virus Vaccine by Mothers in Owerri, Nigeria: A Cross Sectional Study
Authors: Ezeogu Joseph , Asinobi Kingsley , Okeji Chidimma Noela , Chimah Chioma Theresa 
Published: July 2024

Introduction: Human papillomavirus (HPV) vaccination among female children 9-14 years is critical to reducing the burden of HPV-related cancers in Nigeria. We assessed caregivers’ perception and acceptance of HPV vaccination for their wards; using a structured, pretested, self-administered questionnaire in a face-to-face interview among caregivers attending a well-child/immunization clinic in Owerri, Nigeria.
Methodology: Participants were recruited by convenience sampling method between August and October 2023.We analysed the cross-sectional data from 267 caregivers of caregivers aged 20–57years in a Nigerian Teaching hospital. Statistical analysis included descriptive statistics and bivariate analysis to investigate the factors associated with HPV vaccination uptake.
Among the respondents, 132 (49.4%) of them had heard about HPV, and 52 (19.5%) stated that it could prevent cervical cancer. Bivariate analysis, demonstrated that tertiary education in the mother (OR 2.25, 95%CI 1.27 to 4.02) and father (OR 2.25, 95%CI 1.28 to 3.85) were significantly associated with their knowledge of HPV vaccine and their wards’ probability of taking the HPV vaccine. Participants’ intention to give HPV vaccination to their children was 77.5%. Our findings suggest that interventions tailored to enhance education and support of caregivers would significantly increase HPV vaccination among females in Nigeria.
Conclusion: Being well-educated appears to guarantee good knowledge of the HPV vaccine, but not HPV prevention of cervical cancer role. Our respondents’ intention to have the HPV vaccine administered to their children was high. Concerted efforts need to be made by government and health workers to create awareness about HPV infection, HPV vaccine amongst caregivers to enhance HPV vaccine uptake.
Changes of Molecular Glycerophospholipid Species in Plasma and Red Blood Cells During Docosahexaenoic Acid Supplementation
Authors: Uhl Olaf , Demmelmair Hans , Klingler Mario , Koletzko Berthold 
Published: September 2013

AbstractDocosahexaenoic acid (DHA) status is related to health and disease risk. DHA status is mainly determined by dietary DHA intake, since endogenous synthesis of DHA is limited. We aimed to investigate the changes of different molecular glycerophospholipid species containing DHA in plasma and red blood cells (RBC) in response to increased DHA intake. Thirteen healthy adults had their diet supplemented with 510 mg DHA/day for 29 days. Fasted blood samples were taken at 11 time points and glycerophospholipid species were analyzed by liquid chromatography mass spectrometry. In plasma, percentages of glycerophospholipid species containing DHA increased significantly by 64–104 % relative to baseline values during supplementation, but the relative distribution between species was not markedly altered. In RBC, phosphatidylcholine (PtdCho) species containing DHA increased to a similar extent as in plasma, while phosphatidylethanolamine and phosphatidylserine species with DHA increased by only 12–25 %, respectively, which was significantly different compared to PtdCho species (p < 0.01). Despite the high increase, the contribution of DHA PtdCho species to total DHA remained minor (14 % after supplementation). In conclusion, DHA supplementation does not alter the relative distribution of DHA among glycerophospholipid species in plasma. A majority of PtdCho species are rapidly exchanged between plasma lipoproteins and RBC membrane lipids, while there is a minor exchange of phosphatidylethanolamine and phosphatidylserine species.
Perturbation Analysis of Indices of Lifespan Variability
Authors: van Raalte Alyson A. , Caswell Hal 
Published: September 2013

AbstractA number of indices exist to calculate lifespan variation, each with different underlying properties. Here, we present new formulae for the response of seven of these indices to changes in the underlying mortality schedule (life disparity, Gini coefficient, standard deviation, variance, Theil’s index, mean logarithmic deviation, and interquartile range). We derive each of these indices from an absorbing Markov chain formulation of the life table, and use matrix calculus to obtain the sensitivity and the elasticity (i.e., the proportional sensitivity) to changes in age-specific mortality. Using empirical French and Russian male data, we compare the underlying sensitivities to mortality change under different mortality regimes to determine the conditions under which the indices might differ in their conclusions about the magnitude of lifespan variation. Finally, we demonstrate how the sensitivities can be used to decompose temporal changes in the indices into contributions of age-specific mortality changes. The result is an easily computable method for calculating the properties of this important class of longevity indices.
Impact of mean platelet volume on the occurrence and severity of sudden sensorineural hearing loss
Authors: Sagit M , Kavugudurmaz M , Guler S , Somdas M A 
Published: September 2013

AbstractObjective:We aimed to determine: (1) whether mean platelet volume was elevated in patients with sudden sensorineural hearing loss, compared with healthy controls; and (2) whether mean platelet volume level was related to hearing loss severity.Materials and methods:The study included 31 patients with sudden sensorineural hearing loss and 31 age- and sex-matched, healthy controls. Peripheral venous blood samples were taken from subjects and mean platelet volume and levels of glucose, total cholesterol, high-density lipoprotein, low-density lipoprotein and triglyceride were measured.Results:Mean platelet volume was significantly greater in the sudden sensorineural hearing loss group compared with the control group. However, there was no significant correlation between mean platelet volume level and hearing loss severity.Conclusion:Mean platelet volume, a determinant of platelet activation, is elevated in patients with sudden sensorineural hearing loss. To our knowledge, this is the first report investigating mean platelet volume levels in such patients. Our findings indirectly support the hypothesis of vascular impairment as a pathogenetic factor in sudden sensorineural hearing loss.
What is the price of neglecting parasite groups when assessing the cost of co-infection?
Authors: SERRANO E. , MILLÁN J. 
Published: September 2013

SUMMARYAlthough co-infection by multiple groups of pathogens is the norm rather than the exception in nature, most research on the effects of pathogens on their hosts has been largely based on a single or few pathogen species. Nevertheless, the health impact of co-occurring infections is evident, and it is important that scientists should consider pathogen communities rather than single relevant pathogen species when assessing the impact of multiple infections. In this work we illustrate the consequences of neglecting different pathogen taxa (viruses, protozoa, helminths, arthropods) in the explanatory power of a set of Partial Least Squares Regression (PLS-R) models used for exploring the impact of co-infections on the body condition of 57 adult feral cats; 71·5% cats were co-infected by ⩾3 groups of pathogens. The best two PLS-R models provided a first component based on the combination of helminths, protozoa and viruses, explaining 29·15% of body-condition variability. Statistical models, partially considering the pathogen community, lost between 24% and 94% of their explanatory power for explaining the cost of multiple infections. We believe that in the future, researchers assessing the impact of diseases on host life-history traits should take into account a broad representation of the pathogen community, especially during early assessment of the impact of diseases on host health.
Evolutionary history of Ebola virus
Authors: LI Y. H. , CHEN S. P. 
Published: September 2013

SUMMARYSince Ebola virus was discovered in 1970s, the virus has persisted in Africa and sporadic fatal outbreaks in humans and non-human primates have been reported. However, the evolutionary history of Ebola virus remains unclear. In this study, 27 Ebola virus strains with complete glycoprotein genes, including five species (Zaire, Sudan, Reston, Tai Forest, Bundibugyo), were analysed. Here, we propose a hypothesis of the evolutionary history of Ebola virus which will be helpful to investigate the molecular evolution of these viruses.
Linking neural activity to complex decisions
Authors: HAYDEN BENJAMIN , PASTERNAK TATIANA 
Published: September 2013

AbstractIn the 1990s, seminal work from Newsome and colleagues made it possible to study the neuronal mechanisms of simple perceptual decisions. The key strength of this work was the clear and direct link between neuronal activity and choice processes. Since then, a great deal of research has extended these initial discoveries to more complex forms of decision making, with the goal of bringing the same strength of linkage between neural and psychological processes. Here, we discuss the progress of two such research programs, namely our own, that are aimed at understanding memory-guided decisions and reward-guided decisions. These problems differ in the relevant brain areas, in the progress that has been achieved, and in the extent of broader understanding achieved so far. However, they are unified by the use of theoretical insights about how to link neuronal activity to decisions.
Genome signature-based dissection of human gut metagenomes to extract subliminal viral sequences
Authors: Ogilvie Lesley A. , Bowler Lucas D. , Caplin Jonathan , Dedi Cinzia , Diston David , Cheek Elizabeth , Taylor Huw , Ebdon James E. , Jones Brian V. 
Published: September 2013

AbstractBacterial viruses (bacteriophages) have a key role in shaping the development and functional outputs of host microbiomes. Although metagenomic approaches have greatly expanded our understanding of the prokaryotic virosphere, additional tools are required for the phage-oriented dissection of metagenomic data sets, and host-range affiliation of recovered sequences. Here we demonstrate the application of a genome signature-based approach to interrogate conventional whole-community metagenomes and access subliminal, phylogenetically targeted, phage sequences present within. We describe a portion of the biological dark matter extant in the human gut virome, and bring to light a population of potentially gut-specific Bacteroidales-like phage, poorly represented in existing virus like particle-derived viral metagenomes. These predominantly temperate phage were shown to encode functions of direct relevance to human health in the form of antibiotic resistance genes, and provided evidence for the existence of putative ‘viral-enterotypes’ among this fraction of the human gut virome.
In-line digital holographic microscopy using a consumer scanner
Authors: Shimobaba Tomoyoshi , Yamanashi Hiroya , Kakue Takashi , Oikawa Minoru , Okada Naohisa , Endo Yutaka , Hirayama Ryuji , Masuda Nobuyuki , Ito Tomoyoshi 
Published: September 2013

AbstractWe demonstrate an in-line digital holographic microscopy using a consumer scanner. The consumer scanner can scan an image with 4,800 dpi. The pixel pitch is approximately 5.29 μm. The system using a consumer scanner has a simple structure, compared with synthetic aperture digital holography using a camera mounted on a two-dimensional moving stage. In this demonstration, we captured an in-line hologram with 23, 602 × 18, 023 pixels (≈0.43 gigapixels). The physical size of the scanned hologram is approximately 124 mm × 95 mm. In addition, to accelerate the reconstruction time of the gigapixel hologram and decrease the amount of memory for the reconstruction, we applied the band-limited double-step Fresnel diffraction to the reconstruction.
Routing systems to extend the driving range of electric vehicles
Authors: Neaimeh Myriam , Hill Graeme A. , Hübner Yvonne , Blythe Phil T. 
Published: September 2013

This study develops a more accurate range prediction for electric vehicles (EVs) resulting in a routing system that could extend the driving range of EVs through calculating the minimum energy route to a destination, based on topography and traffic conditions of the road network. Energy expenditure of EVs under different conditions is derived using high‐resolution real‐world data from the SwitchEV trial. The SwitchEV trial has recorded the second‐by‐second driving events of 44 all‐electric vehicles covering a distance of over 400 000 miles across the North East of England, between March 2010 and May 2013. Linear models are used to determine the energy expenditure equations and Dijkstra's graph search algorithm is used to find the route minimising energy consumption. The results from this study are being used to better inform the decisions of the smart navigation and eco‐driving assist systems in EVs, thus improving the intelligent transport systems provisions for EV drivers. The outputs of the research are twofold: providing more accurate estimations of available range and supporting drivers’ optimisation of energy consumption and as a result extending their driving range. Both outputs could help mitigate range anxiety and make EVs a more attractive proposition to potential customers.
Influence of the channel electric field distribution on the polarization Coulomb field scattering in AlGaN/AlN/GaN heterostructure field-effect transistors
Authors: Yu Yingxia , Lin Zhaojun , Luan Chongbiao , Lv Yuanjie , Feng Zhihong , Yang Ming , Wang Yutang , Chen Hong 
Published: September 2013

Using the Quasi-Two-Dimensional (quasi-2D) model, the current-voltage (I-V) characteristics of AlGaN/AlN/GaN heterostructure field-effect transistors (HFETs) with different gate length were simulated based on the measured capacitance-voltage (C-V) characteristics and I-V characteristics. By analyzing the simulation results, we found that the different polarization charge distribution generated by the different channel electric field distribution can result in different polarization Coulomb field scattering, and the difference of the electron mobility mostly caused by the polarization Coulomb field scattering can reach up to 1829.9 cm2/V·s for the prepared AlGaN/AlN/GaN HFET. In addition, it was also found that when the two-dimension electron gas (2DEG) sheet density is modulated by the drain-source bias, the electron mobility appears peak with the variation of the 2DEG sheet density, and the ratio of gate length to drain-source distance is smaller, the 2DEG sheet density corresponding to the peak point is higher.