bluuebunny/crossref_metadata_2025_split huggingface dataset:
Syndromic surveillance for local outbreak detection and awareness: evaluating outbreak signals of acute gastroenteritis in telephone triage, web-based queries and over-the-counter pharmacy sales
Authors: ANDERSSON T. , BJELKMAR P. , HULTH A. , LINDH J. , STENMARK S. , WIDERSTRÖM M. 
Published: May 2013

SUMMARYFor the purpose of developing a national system for outbreak surveillance, local outbreak signals were compared in three sources of syndromic data – telephone triage of acute gastroenteritis, web queries about symptoms of gastrointestinal illness, and over-the-counter (OTC) pharmacy sales of antidiarrhoeal medication. The data sources were compared against nine known waterborne and foodborne outbreaks in Sweden in 2007–2011. Outbreak signals were identified for the four largest outbreaks in the telephone triage data and the two largest outbreaks in the data on OTC sales of antidiarrhoeal medication. No signals could be identified in the data on web queries. The signal magnitude for the fourth largest outbreak indicated a tenfold larger outbreak than officially reported, supporting the use of telephone triage data for situational awareness. For the two largest outbreaks, telephone triage data on adult diarrhoea provided outbreak signals at an early stage, weeks and months in advance, respectively, potentially serving the purpose of early event detection. In conclusion, telephone triage data provided the most promising source for surveillance of point-source outbreaks.
Can we achieve high uptakes of influenza vaccination of healthcare workers in hospitals? A cross-sectional survey of acute NHS trusts in England
Authors: EDELSTEIN M. , PEBODY R. 
Published: May 2013

SUMMARYIt is unknown which intervention strategies are used or effective to increase influenza vaccine uptake by healthcare workers (HCWs) in acute hospitals in England. We undertook a survey in acute hospitals, described strategies employed from 2008 to 2012 and used multivariable binomial regression to identify those effective. Eighty out of 166 trusts responded and reported 25 strategies. Every intervention showed increased use: peer vaccination from 3·8% to 38·8% (+921%); educational DVDs from 3·8% to 22·5% (+492%); Twitter from 2·5% to 12·5% (+400%) and Facebook from 1·3% to 6·3% (+384%). Peer vaccination increased uptake by 7·3% [95% confidence interval (CI) 1·1–13·6,P = 0·02] overall; educational DVDs by 9·7% overall (95% CI 1·8–17·6,P = 0·02), 11·9% in non-doctor, non-nurse HCWs (95% CI 0·9–22·8,P = 0·03). For doctors, using a champion doctor increased uptake by 17·8% (95% CI 7·6–28·0,P < 0·01). No intervention increased uptake by nurses. Increasing uptake requires multi-intervention strategies targeted at different HCW groups.
Development and Evaluation of a Novel Topical Treatment for Acne with Azelaic Acid-Loaded Nanoparticles
Authors: Reis Catarina Pinto , Gomes Ana , Rijo Patrícia , Candeias Sara , Pinto Pedro , Baptista Marina , Martinho Nuno , Ascensão Lia 
Published: May 2013

AbstractAzelaic acid (AzA) is used in the treatment of acne. However, side effects and low compliance have been associated with several topical treatments with AzA. Nanotechnology presents a strategy that can overcome these problems. Polymeric nanoparticles can control drug release and targeting and reduce local drug toxicity. The aim of this study was to produce and evaluate an innovative topical treatment for acne with AzA-loaded poly-dl-lactide/glycolide copolymer nanoparticles. A soft white powder of nanoparticles was prepared. The mean size of loaded nanoparticles was <400 nm and zeta potential was negative. Spherical nanoparticles were observed by scanning electron microscopy. Encapsulation efficiency was around 80% and a strong interaction between the polymer and the drug was confirmed by differential scanning calorimetric analysis. In vitro drug release studies suggested a controlled and pulsatile release profile. System efficacy tests suggested similar results between the loaded nanoparticles and the nonencapsulated drug against the most common bacteria associated with acne. Cytotoxicity of AzA-loaded nanoparticles was concentration dependent, although not pronounced. The occluded patch test seemed to indicate that the formulation excipients were safe and thus AzA-loaded nanoparticles appear to be an efficient and safe treatment for acne.
On the probability of habitable planets
Authors: Forget François 
Published: May 2013

AbstractIn the past 15 years, astronomers have revealed that a significant fraction of the stars should harbour planets and that it is likely that terrestrial planets are abundant in our galaxy. Among these planets, how many are habitable, i.e. suitable for life and its evolution? These questions have been discussed for years and we are slowly making progress. Liquid water remains the key criterion for habitability. It can exist in the interior of a variety of planetary bodies, but it is usually assumed that liquid water at the surface interacting with rocks and light is necessary for emergence of a life able to modify its environment and evolve. The first key issue is thus to understand the climatic conditions allowing surface liquid water assuming a suitable atmosphere. These have been studied with global mean one-dimensional (1D) models which have defined the ‘classical habitable zone’, the range of orbital distances within which worlds can maintain liquid water on their surfaces (Kasting et al. 1993). A new generation of 3D climate models based on universal equations and tested on bodies in the solar system are now available to explore with accuracy climate regimes that could locally allow liquid water. The second key issue is now to better understand the processes which control the composition and the evolution of the atmospheres of exoplanets, and in particular the geophysical feedbacks that seem to be necessary to maintain a continuously habitable climate. From that point of view, it is not impossible that the Earth's case may be special and uncommon.
NONASSOCIATIVE SUBSTRUCTURAL LOGICS AND THEIR SEMILINEAR EXTENSIONS: AXIOMATIZATION AND COMPLETENESS PROPERTIES
Authors: CINTULA PETR , HORČÍK ROSTISLAV , NOGUERA CARLES 
Published: May 2013

AbstractSubstructural logics extending the full Lambek calculus FL have largely benefited from a systematical algebraic approach based on the study of their algebraic counterparts: residuated lattices. Recently, a nonassociative generalization of FL (which we call SL) has been studied by Galatos and Ono as the logic of lattice-ordered residuated unital groupoids. This paper is based on an alternative Hilbert-style presentation for SL which is almost MP-based. This presentation is then used to obtain, in a uniform way applicable to most (both associative and nonassociative) substructural logics, a form of local deduction theorem, description of filter generation, and proper forms of generalized disjunctions. A special stress is put on semilinear substructural logics (i.e., logics complete with respect to linearly ordered algebras). Axiomatizations of the weakest semilinear logic over SL and other prominent substructural logics are provided and their completeness with respect to chains defined over the real unit interval is proved.
A Time to Event Tutorial for Pharmacometricians
Authors: Holford Nick 
Published: May 2013

Models for time to event provide the link between standard pharmacokinetic–dynamic models disease progression, and clinical outcome events. The biological basis for events may be expressed quantitatively in terms of a hazard function. This tutorial explains hazards and how doses can be linked to events predicted from hazard functions.CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e43; doi:10.1038/psp.2013.18; advance online publication 15 May 2013
STIM1 negatively regulates Ca2+ release from the sarcoplasmic reticulum in skeletal myotubes
Authors: Lee Keon Jin , Woo Jin Seok , Hwang Ji-Hye , Hyun Changdo , Cho Chung-Hyun , Kim Do Han , Lee Eun Hui 
Published: May 2013

STIM1 (stromal interaction molecule 1) mediates SOCE (store-operated Ca2+ entry) in skeletal muscle. However, the direct role(s) of STIM1 in skeletal muscle, such as Ca2+ release from the SR (sarcoplasmic reticulum) for muscle contraction, have not been identified. The times required for the maximal expression of endogenous STIM1 or Orai1, or for the appearance of puncta during the differentiation of mouse primary skeletal myoblasts to myotubes, were all different, and the formation of puncta was detected with no stimulus during differentiation, suggesting that, in skeletal muscle, the formation of puncta is a part of the differentiation. Wild-type STIM1 and two STIM1 mutants (Triple mutant, missing Ca2+-sensing residues but possessing the intact C-terminus; and E136X, missing the C-terminus) were overexpressed in the myotubes. The wild-type STIM1 increased SOCE, whereas neither mutant had an effect on SOCE. It was interesting that increases in the formation of puncta were observed in the Triple mutant as well as in wild-type STIM1, suggesting that SOCE-irrelevant puncta could exist in skeletal muscle. On the other hand, overexpression of wild-type or Triple mutant, but not E136X, attenuated Ca2+ releases from the SR in response to KCl [evoking ECC (excitation–contraction coupling) via activating DHPR (dihydropyridine receptor)] in a dominant-negative manner. The attenuation was removed by STIM1 knockdown, and STIM1 was co-immunoprecipitated with DHRP in a Ca2+-independent manner. These results suggest that STIM1 negatively regulates Ca2+ release from the SR through the direct interaction of the STIM1 C-terminus with DHPR, and that STIM1 is involved in both ECC and SOCE in skeletal muscle.
Research on lightning performance of AC/DC hybrid transmission lines on the same tower
Authors: Wei Shi , Qingmin Li , Liang Zou , Li Zhang , Xinchang Lu 
Published: May 2013

Rapid expansion of power system and the limitation of transmission corridor resources have indispensably promoted the development of AC/DC hybrid transmission lines on the same tower under special situations, especially for ultra‐high voltage systems being established in China. A hybrid tower model incorporating a double‐circuit AC transmission and a bipolar DC transmission is proposed in the study. The lightning performance of AC/DC hybrid transmission lines is investigated based on electro‐magnetic transient program (EMTP) and leader progression model, taking into account the operating voltage of transmission lines as well as the competition of multiple upward leaders. The impact of tower's height, footing resistance, arrangements of ground wires and ground obliquity on lightning protection performance is also analysed. In accordance with the ± 800 kV bipolar DC and the 500 kV double‐circuit AC transmission lines on the same tower, the results show that the back flashover and the shielding failure is relatively serious for a 500 kV AC transmission line, which should be paid more attention to. Finally, several methods that may be used to improve lightning protection performance of the AC/DC hybrid transmission lines are presented, such as reducing the tower's height, using a negative protection angle and installing additional ground wires.
ADAM-10 and -17 regulate endometriotic cell migration via concerted ligand and receptor shedding feedback on kinase signaling
Authors: Miller Miles A. , Meyer Aaron S. , Beste Michael T. , Lasisi Zainab , Reddy Sonika , Jeng Karen W. , Chen Chia-Hung , Han Jongyoon , Isaacson Keith , Griffith Linda G. , Lauffenburger Douglas A. 
Published: May 2013

Significance
Regulated cell-surface proteolysis underpins processes of cellular migration in both physiological and pathological contexts. However, comprehending how multiple proteolytic events cohesively integrate to yield context-dependent cellular behavior remains a challenge. Here we present an experimental/computational paradigm for analyzing networks of protease activities that interface with signaling pathways to influence cellular migration in the invasive disease of endometriosis. We find that induced cellular migration is a quantitative consequence of positive feedback through ligand release and negative feedback through receptor shedding, which furthermore drives rapid resistance to kinase inhibitor treatment. Targeted clinical proteomics confirms dysregulated proteolysis in endometriosis.
Tissue plasminogen activator regulates Purkinje neuron development and survival
Authors: Li Jianxue , Yu Lili , Gu Xuesong , Ma Yinghua , Pasqualini Renata , Arap Wadih , Snyder Evan Y. , Sidman Richard L. 
Published: May 2013

Significance
Cerebellar Purkinje neurons (PNs) strongly affect motor coordination and learning. PN study has contributed significantly to fundamental concepts of modern neuroscience. The present investigation defines distinctive molecular signaling pathways through which tissue plasminogen activator/plasmin-based proteolysis regulates postnatal PN dendrite development, synapse formation, mitochondrial morphology and function, and PN survival. These pathways involve differentially acting downstream constituents, including protein kinase Cγ, brain-derived neurotrophic factor, and a voltage-dependent anion channel. The metabolic mechanisms established here may apply to the development and degeneration of PNs and additional types of neurons in many animal and human brain diseases in which PNs are notably vulnerable.
Distinct quaternary structures of the AAA+ Lon protease control substrate degradation
Authors: Vieux Ellen F. , Wohlever Matthew L. , Chen James Z. , Sauer Robert T. , Baker Tania A. 
Published: May 2013

SignificanceLon protease degrades unfolded or damaged proteins as well as numerous cellular regulatory proteins. How these different classes of substrates are recognized is poorly understood. We find that Lon hexamers assemble via a matrix of N-domain interactions to form a dodecamer with altered substrate-degradation properties. Access of protein substrates to the degradation machinery in the dodecamer appears to require passage through equatorial portals. As a consequence, large substrates that are efficiently degraded by hexamers seem to be preferentially excluded from dodecamers. This gating mechanism allows the substrate repertoire of Lon to be adjusted by its assembly state.
Loss of Plastoglobule Kinases ABC1K1 and ABC1K3 Causes Conditional Degreening, Modified Prenyl-Lipids, and Recruitment of the Jasmonic Acid Pathway
Authors: Lundquist Peter K. , Poliakov Anton , Giacomelli Lisa , Friso Giulia , Appel Mason , McQuinn Ryan P. , Krasnoff Stuart B. , Rowland Elden , Ponnala Lalit , Sun Qi , van Wijk Klaas J. 
Published: May 2013

Abstract
Plastoglobules (PGs) are plastid lipid-protein particles. This study examines the function of PG-localized kinases ABC1K1 and ABC1K3 in Arabidopsis thaliana. Several lines of evidence suggested that ABC1K1 and ABC1K3 form a protein complex. Null mutants for both genes (abc1k1 and abc1k3) and the double mutant (k1 k3) displayed rapid chlorosis upon high light stress. Also, k1 k3 showed a slower, but irreversible, senescence-like phenotype during moderate light stress that was phenocopied by drought and nitrogen limitation, but not cold stress. This senescence-like phenotype involved degradation of the photosystem II core and upregulation of chlorophyll degradation. The senescence-like phenotype was independent of the EXECUTER pathway that mediates genetically controlled cell death from the chloroplast and correlated with increased levels of the singlet oxygen–derived carotenoid β-cyclocitral, a retrograde plastid signal. Total PG volume increased during light stress in wild type and k1 k3 plants, but with different size distributions. Isolated PGs from k1 k3 showed a modified prenyl-lipid composition, suggesting reduced activity of PG-localized tocopherol cyclase (VTE1), and was consistent with loss of carotenoid cleavage dioxygenase 4. Plastid jasmonate biosynthesis enzymes were recruited to the k1 k3 PGs but not wild-type PGs, while pheophytinase, which is involved in chlorophyll degradation, was induced in k1 k3 and not wild-type plants and was localized to PGs. Thus, the ABC1K1/3 complex contributes to PG function in prenyl-lipid metabolism, stress response, and thylakoid remodeling.
Analyzing web citations availability and half‐life in medical journals
Authors: Jalalifard Mariam , Norouzi Yaghoub , Isfandyari‐Moghaddam Alireza 
Published: May 2013

PurposeThe aim of this study is to compare the situation of internet resource citations in scientific articles of the journals of Shahid Beheshti University of Medical Sciences from 2005‐2009.Design/methodology/approachThe research method is an analytical survey with webometrics and citation analysis. The internet was used as a tool for accessing articles. They are separately analyzed on the basis of journal name and publication year. The analysis is done using MATLAB and Excel software.FindingsA total of 717 articles from seven journals during five years were reviewed. Of 13,448 citations extracted, 120 internet references were found. The final results indicated that the sum of web citations is less than 1 per cent of total citations and only 52 per cent of internet citations in studied journal articles are available. The average half‐life for the medical journals is estimated to be 1.02 years.Practical implicationsTo increase the rate of URLs availability, publishers should oblige authors to utilize online archives such as WebCite to preserve expected information for all of the citations referred to in their articles.Originality/valueThis research would be valuable since it is the first that studies stability and persistence of URL domains of medical journals published in Shahid Beheshti University of Medical Sciences according to type of domain names and file extensions. Moreover, this is the first time that the half‐life for medical universities web citations is calculated.
Conceptualizing perceived affordances in social media interaction design
Authors: Zhao Yuxiang , Liu Jiang , Tang Jian , Zhu Qinghua 
Published: May 2013

PurposeThe purpose of this paper is to theoretically develop the concept of perceived affordance based on the existing studies, and to construct a conceptual framework to show how perceived affordances can facilitate the interaction design of social media.Design/methodology/approachThe paper provides a review of the relevant literature on affordance and perceived affordance, and conceptually proposes a typology of perceived affordances in social media and an integrative framework for interaction design from sociomateriality perspective. Furthermore, a brief empirical example on the interaction design of crowdsourcing systems is used to ground and illustrate the authors' conceptual framework.FindingsThe paper shows that the perceived affordances may have multi‐facet characteristics and the interaction design of social media should reflect the multi‐dimensional perceived affordances. The perceived affordances can support or facilitate the design of basic elements of social media, such as content and form, to enhance both usability (human‐computer interaction) and sociability (human‐human interaction). A position of constitutive entanglement does not privilege either users or social media artifacts, nor does it provide a rigid triangle among these three components. Instead, the perceived affordances play a critical role in integrating the key components in social media interaction design as an ensemble.Originality/valueThe paper attempts to explore and develop the concept of perceived affordance and employ it as a theoretical lens to underpin interaction design of social media. Overall, the authors' study contributes to the design science literature in the information management field by elaborating a new theoretical perspective and providing a conceptual framework for the researchers and designers.
Ninja Kitchen to the rescue
Authors: Quick Virginia , Corda Kirsten W. , Chamberlin Barbara , Schaffner Donald W. , Byrd‐Bredbenner Carol 
Published: May 2013

PurposeThe purpose of this paper is to assess the effect of Ninja Kitchen, a food safety educational video game, on middle school students' food safety knowledge, psychographic characteristics, and usual and intended behaviors.Design/methodology/approachThe experimental group (n=903) completed the following activities about one week apart from each other: pretest, played the game, posttest, and follow‐up test. The control group (n=365) completed the same activities at similar intervals but did not have access to the game until after the follow‐up test.FindingsLinear mixed‐effects models, controlling for gender, grade, and geographic location revealed significant time by group effects for knowledge of safe cooking temperatures for animal proteins and danger zone hazard prevention, and usual produce washing behaviors. Pairwise comparisons, adjusted for multiple comparisons, indicated that after playing the game, the experimental group felt more susceptible to foodborne illness, had stronger attitudes toward the importance of handling food safely and handwashing, had greater confidence in their ability to practice safe food handling, and had greater intentions to practice handwashing and safe food handling. Teachers and students found the game highly acceptable.Originality/valueThe game has the potential to promote positive food safety behaviors among youth, in a fun and educational format.
UK consumer reactions to organic certification logos
Authors: Gerrard Catherine , Janssen Meike , Smith Laurence , Hamm Ulrich , Padel Susanne 
Published: May 2013

PurposeThe purpose of this paper is to consider whether UK consumers recognise and trust organic certification logos and whether the presence of these logos on a product increases consumer willingness to pay for that product.Design/methodology/approachTo ascertain the reaction of UK consumers to organic certification logos commonly used in the UK, this study makes use of three methods: focus groups, a consumer survey and a willingness to pay experiment (choice experiment).FindingsThese three approaches reveal that UK consumers associate certain benefits with organic foods but are generally unaware of how the industry is regulated. With regards to trust of the logo, the standards they think underlie the logo and the inspection system that they think is associated with the logo, UK consumers rate the Soil Association and Organic Farmers and Growers logos more highly than the EU logo or products labelled with just the word “organic”. They appear willing to pay a premium for the additional assurance that these two logos provide, suggesting that where they are recognised, certification logos are valued.Originality/valueTo the authors' knowledge, no previous studies exist on whether UK consumers recognise and trust different organic certification logos. These findings show that where such logos are recognised they can help to give some assurance to the UK consumer and this is reflected in a willingness to pay a premium for foods labelled with the Soil Association and Organic Farmers and Growers certification logos, as opposed to no logo or the (less well known) EU logo.