bluuebunny/crossref_metadata_2025_split huggingface dataset:
Plasma Levels of E-cadherin and MMP-13 in Prostate Cancer Patients: Correlation with PSA, Testosterone and Pathological Parameters
Authors: Bonaldi Carolina M. , Azzalis Ligia A. , Junqueira Virginia B.C. , de Oliveira Claudia G.B. , Boas Viviane A. Vilas , Gáscon Thaís M. , Gehrke Flávia S. , Kuniyoshi Renata K. , Alves Beatriz C.A. , Fonseca Fernando L.A. 
Published: March 2015

Aims and Background Prostate cancer is the most common malignant tumor in men. Serum prostate-specific antigen (PSA), Gleason score and clinical range at the time of diagnosis are important factors to predict prognosis and outcome after therapy but additional accurate and reliable biomarkers are still wanted. So far, few biomarkers of prostate cancer have been successfully implemented and are being used in clinical practice. However, modifications of E-cadherin and MMP-13 expression are likely to be involved in prostate cancer invasion and thus are potential biomarkers for prognosis. Patients and Methods We analyzed the concentrations of E-cadherin and MMP-13 in plasma of patients with prostate cancer at diagnosis and 3 and 6 months after the beginning of treatment and related these measures to free and total PSA and other clinical features. Results The concentration of E-cadherin was lower in patients with prostate cancer compared to the control group, but there was no difference in the concentration of MMP-13 between these two groups. During treatment, however, we found no significant differences between the concentrations of MMP-13 and E-cadherin, but we observed a significant positive correlation between total PSA and E-cadherin plasma concentration at the third month of treatment and between total testosterone and MMP-13 plasma concentration before the start of treatment. Conclusions The results suggest that these parameters could be used both in the diagnosis and prognosis of prostate cancer.
Neoadjuvant Crizotinib in Advanced Inflammatory Myofibroblastic Tumour with ALK Gene Rearrangement
Authors: Rafee Shereen , Elamin Yasir Y. , Joyce Eimear , Toner Mary , Flavin Richard , McDermott Ronan , Sheehy Niall , Hennessy Bryan , O'Byrne Kenneth , Gleeson Noreen , Osman Nemer 
Published: March 2015

Background Inflammatory myofibroblastic tumours (IMTs) are rare sarcomas that were first described in the lung. They are composed of myofibroblastic mesenchymal spindle cells accompanied by an inflammatory infiltrate of plasma cells. Complete resection is the treatment of choice. There is currently no standard treatment for inoperable or recurrent disease. Expression of ALK protein triggered by ALK gene rearrangement at chromosome 2p23 has been found in 36%-60% of IMTs. Case report We report a rapid early response to crizotinib as neoadjuvant therapy, enabling surgical excision of a large ALK(-translocated IMT, which resulted in complete disease clearance. To the best of our knowledge, this is the first case in the literature of a patient with IMT in whom crizotinib was used successfully in the neoadjuvant or curative setting.
Surgical Treatment of Rectourinary Fistulas: Review of the Literature
Authors: Crestani Alessandro , Dal Mora Fabrizio 
Published: March 2015

Background A rectourethral fistula (RUF) is an uncommon complication resulting from surgery, radiation, or trauma. Retrospective studies and case reports have highlighted different approaches for surgical repair. Objective The aim of this study was to review our experience with surgical management of RUF. Data sources MEDLINE (PubMed, Ovid) and the Cochrane Library were searched by using the terms RUFs urethrorectal fistulas, and prostatourethral-rectal fistulas. Study selection All studies were retrospective and in English. Of the records identified, 31 series were included. Results Four hundred sixty-five patients were identified. Most patients underwent one of four categories of repair: transanal (4.7%), transabdominal (14.1%), transsphincteric (26.6%), and transperineal (57.6%). Tissue interposition flaps, predominantly gracilis muscle, were used in 56% of repairs. The fistula was successfully closed in 93.9% of patients. Conclusions Regardless of complexity, RUFs have an initial closure rate of 93.9%.
Ancient Greek Deathscapes
Authors: Dimakis Nikolas 
Published: March 2015

ABSTRACTPersonal, yet utterly universal. Inevitable, yet unknowable. Death has been a dominant theme in all cultures since time immemorial. Central to the theme of death is the burial of the dead in cemeteries. But death also unfolds in other areas such as natural spaces, places of worship, and battlefields. These then become places of intense private and personal significance, which simultaneously act as shared collective sites of experience and remembrance. This article seeks to provide an insight into “deathscapes” and the relationship between space, place, and death in the Classical period by drawing on published archaeological evidence, mainly from southern Greece, and sociological and anthropological theory.
Peripheral Blood-Derived Mesenchymal Stem Cells: Candidate Cells Responsible for Healing Critical-Sized Calvarial Bone Defects
Authors: Li Shaowei , Huang Ke-Jung , Wu Jen-Chieh , Hu Michael S. , Sanyal Mrinmoy , Hu Min , Longaker Michael T. , Lorenz H. Peter 
Published: March 2015

Abstract
Postnatal tissue-specific stem/progenitor cells hold great promise to enhance repair of damaged tissues. Many of these cells are retrieved from bone marrow or adipose tissue via invasive procedures. Peripheral blood is an ideal alternative source for the stem/progenitor cells because of its ease of retrieval. We present a coculture system that routinely produces a group of cells from adult peripheral blood. Treatment with these cells enhanced healing of critical-size bone defects in the mouse calvarium, a proof of principle that peripheral blood-derived cells can be used to heal bone defects. From these cells, we isolated a subset of CD45− cells with a fibroblastic morphology. The CD45− cells were responsible for most of the differentiation-induced calcification activity and were most likely responsible for the enhanced healing process. These CD45− fibroblastic cells are plastic-adherent and exhibit a surface marker profile negative for CD34, CD19, CD11b, lineage, and c-kit and positive for stem cell antigen 1, CD73, CD44, CD90.1, CD29, CD105, CD106, and CD140α. Furthermore, these cells exhibited osteogenesis, chondrogenesis, and adipogenesis capabilities. The CD45− fibroblastic cells are the first peripheral blood-derived cells that fulfill the criteria of mesenchymal stem cells as defined by the International Society for Cellular Therapy. We have named these cells “blood-derived mesenchymal stem cells.”
Rencontre et discours de la méthode
Authors: Krymko-Bleton Irène 
Published: March 2015

La recherche d’orientation psychanalytique ne va pas de soi à l’université, tant à cause du paradoxe de la transmission du savoir analytique par une pédagogie, qu’à cause de conceptions actuellement prédominantes sur la nature de la recherche universitaire (en tout cas, en psychologie). Le présent article fait écho à l’appel lancé il y a une dizaine d’années par Sophie de Mijolla-Mellor pour un « décentrement » de la recherche psychanalytique. L’auteure présente deux exemples de travaux universitaires où sont directement mises à profit pragmatique, analyse de discours et autres disciplines étudiant les échanges langagiers, afin de développer la recherche d’orientation psychanalytique.
Meeting of Minds and Futures: The Nature of Knowledge in Diverse Global Settings
Authors: Hoppers Catherine A. Odora , Sandgren Björn 
Published: March 2015

When we think of communities of the future, we have to think of new social contracts between universities and society with a different ecology, and an intense compatibility towards transdisciplinarity. We know that today there is a need for truly fundamental reflections and questions on knowledge as the building block of global societies worldwide. But we suffer from a lack of clear understanding of what is the ‘definition’ of the knowledge that we are talking about. Universities are awash with literature on knowledge societies, knowledge economies, and scientific knowledge, but there is no notion of the social contract that should underpin the different understandings of knowledge as they reveal themselves in diverse settings. This article summarises many conversations between the two co-authors with Jarl Bengtsson as they battled to find answers to these pertinent questions and some of the deep issues facing the whole of humanity.
Altered structural network in temporal lobe epilepsy with focal to bilateral tonic–clonic seizures
Authors: Ge Yi , Chen Cong , Li Hong , Wang Ruyi , Yang Yuyu , Ye Lingqi , He Chenmin , Chen Ruotong , Wang Zijian , Shao Xiaotong , Gong Yuting , Yang Linglin , Wang Shan , Zhou Jiping , Wu Xunyi , Wang Shuang , Ding Yao 
Published: August 2024

AbstractObjectivesThis study aims to investigate whether alterations in white matter topological networks are associated with focal to bilateral tonic–clonic seizures (FBTCS) in temporal lobe epilepsy (TLE). Additionally, we investigated the variables contributing to memory impairment in TLE.MethodsThis cross‐sectional study included 88 unilateral people with TLE (45 left/43 right), and 42 healthy controls. Graph theory analysis was employed to compare the FBTCS (+) group (n = 51) with the FBTCS (−) group (n = 37). The FBTCS (+) group was subcategorized into current‐FBTCS (n = 31) and remote‐FBTCS (n = 20), based on the history of FBTCS within 1 year or longer than 1 year before scanning, respectively. We evaluated the discriminatory power of topological network properties by receiver operating characteristic (ROC) analysis. Generalized linear models (GLMs) were employed to investigate variables associated with memory impairment in TLE.ResultsGlobal efficiency (Eg) was significantly reduced in the FBTCS (+) group, especially in the current‐FBTCS subgroup. Greater disruption of regional properties in the ipsilateral occipital and temporal association cortices was observed in the FBTCS (+) group. ROC analysis revealed that Eg, normalized characteristic shortest path length, and nodal efficiency of the ipsilateral middle temporal gyrus could distinguish between FBTCS (+) and FBTCS (−) groups. Additionally, GLMs linked the occurrence of current FBTCS with poorer verbal memory outcomes in TLE.InterpretationOur study suggests that abnormal networks could be the structural basis of seizure propagation in FBTCS. Strategies aimed at reducing the occurrence of FBTCS could potentially improve the memory outcomes in people with TLE.
Multifunctional Yb3Si2C2 with High‐Performance Terahertz Shielding for Future 6G Communications
Authors: Qiu Nianxiang , Zhou Xiaobing , Huang Qing , Ye Jichun , Du Shiyu 
Published: August 2024

AbstractThe development of next‐generation 6G communications is anticipated to expand into extreme environments, necessitating superior terahertz (THz) electromagnetic interference (EMI) shielding materials. Herein, structural stability, electronic and optical properties of rare earth silicide carbide Yb3Si2C2 are investigated using first principles density functional calculations and semi‐classical Boltzmann transport theory. The calculation results show Yb3Si2C2 is determined to be experimentally synthesized with high temperature stability with a certain fluctuating C2 pair orientation. In addition, Yb3Si2C2 is identified as a soft, tough, and damage‐resistant ceramic with low shear deformation resistance and easy cleavage, ensuring its durability in irradiation environments. Due to the layered structure and excellent electrical conductivity, Yb3Si2C2 demonstrates high reflectivity and low transmittance for terahertz electromagnetic waves, along with 62% solar absorptivity and 33% IR emissivity. Remarkably, the total shielding effectiveness of Yb3Si2C2 with thicknesses of 5 µm and above follows the widely‐used Simon's formula. The average total shielding effectiveness of 5 µm‐thick and 10 µm‐thick Yb3Si2C2 across the entire THz region reaches 63 and 110 dB, respectively, which turns out to be the top compared to the results reported. Therefore, the multifunctional intrinsic properties of Yb3Si2C2 materials hold great promise for miniaturized, high‐performance terahertz EMI shielding, even in extreme environments.
Highly Safe, Ultra‐Thin MOF‐Based Solid Polymer Electrolytes for Superior All‐Solid‐State Lithium‐Metal Battery Performance
Authors: Nguyen Manh Cuong , Nguyen Hoang Long , Duong Thi Phuong Mai , Kim Sung‐Hoon , Kim Ji‐Young , Bae Jee‐Hwan , Kim Hyun‐Kyung , Lim Sung Nam , Ahn Wook 
Published: August 2024

AbstractPolyethylene oxide (PEO)/lithium bis(trifluoromethanesulfonyl)imide (LiTFSI) is among the most promising candidates for developing solid polymer electrolytes (SPEs) for all‐solid‐state lithium‐metal batteries (ASSLMBs). However, practical applications of the PEO/LiTFSI system face challenges due to its relatively low ionic conductivity and low Li+ transference number. To address these issues, a method is proposed that incorporates multiple components, including zeolitic imidazolate frameworks (ZIF‐67) as fillers and ionic liquid electrolytes (ILEs) as plasticizers, into a PEO/LiTFSI matrix. By optimizing the fabrication process, ultra‐thin membranes of the integrated electrolyte PEO/LiTFSI‐ILE‐ZIF‐67 (PLiZ) with a thickness of 32 µm are developed, achieving high ionic conductivity (1.19 × 10−4 S cm−1 at 25 °C), broad electrochemical stability (5.66 V), and high lithium‐ion mobility (0.8). As a result, the fabricated ASSLMBs exhibited excellent cycle stability at both room temperature and 60 °C, delivering an initial specific discharge capacity of 166.4 mAh g−1 and an impressive capacity retention of 83.7% after 1000 cycles at 3C under 60 °C, corresponding to a low fading rate of 0.0163% per cycle. Additionally, the designed SPEs demonstrated high safety properties, as shown by the successful cutting and folding of a working LiFePO4/PLiZ/Li pouch cell. Therefore, this study presents a comprehensively improved method for developing high‐performance ASSLMBs.
Fabrication Strategies for Bioinspired and Functional Lung‐on‐Chips
Authors: Doryab Ali , Braig Johannes , Jungst Tomasz , Ryma Matthias , Groll Jürgen 
Published: August 2024

AbstractLung‐on‐chips (LoCs) are advanced microsystems designed to culture pulmonary cells under physiologically relevant conditions, including air–liquid interface, cell stretch, and shear stress. As the most promising preclinical models, the LoCs are aimed to reduce and ultimately replace conventional ineffective animal studies. Biomimetic and functional LoCs lead to more translational preclinical studies that effectively address unmet needs across therapeutic areas. A variety of cell‐ and scaffold‐based techniques are employed to establish biomimetic pulmonary cell models that closely resemble their in vivo counterparts, which is a challenging yet critical aspect of LoCs. Herein, the challenges encountered in biomimetic LoCs are discussed, and the future perspectives toward higher biomimicry using advanced biofabrication approaches are explored.
1 µm‐Thick Robust Gel Polymer Electrolyte with Excellent Interfacial Stability for High‐Performance Li Metal Batteries
Authors: Feng Jianwen , Wang Jiayi , Gu Qiao , Li Pingting , Xu Hongli , Deng Yonghong , Gao Ping 
Published: August 2024

AbstractGel polymer electrolytes (GPEs) hold great promise for lithium (Li) metal batteries (LMBs). Nevertheless, a critical challenge lies in reducing the thickness of GPEs while maintaining their mechanical integrity to achieve high‐energy‐density LMBs. Additionally, protecting the Li metal anode via electrolyte engineering in GPEs remains demanding. Herein, an innovative ultrathin (1 µm‐thick) yet robust GPE developed using an in situ curing technique, featuring a nanofibrous, exceptionally strong polyethylene separator is presented. The unique microstructure, interfacial conformability, and ultrahigh mechanical robustness of the ultrathin polyethylene separator are thoroughly verified. Enhanced ionic association within the GPE is achieved due to the strong affinity of electrolyte solvent with the fluorinated polymer network, as confirmed by large‐scale molecular dynamics simulations. The optimized solvation structure with high contact ion pairs and aggregate fractions contributes to forming an anion‐derived inorganic‐rich solid electrolyte interphase (SEI), thereby protecting the lithium anode. Benefiting from the ultrahigh robustness of GPE and the excellent interfacial stability, the Li metal full cell with a high mass loading LiNi0.8Co0.1Mn0.1O2 cathode (≈17.3 mg cm−2) and thin Li foil anode (50 µm) demonstrates 91% capacity retention after 200 cycles. This design demonstrates a feasible approach toward the practical quasi‐solid‐state LMBs.
In‐Depth Understanding of Interfacial Na+ Behaviors in Sodium Metal Anode: Migration, Desolvation, and Deposition
Authors: Huang Fei , Xu Peng , Fang Guozhao , Liang Shuquan 
Published: August 2024

AbstractInterfacial Na+ behaviors of sodium (Na) anode severely threaten the stability of sodium‐metal batteries (SMBs). This review systematically and in‐depth discusses the current fundamental understanding of interfacial Na+ behaviors in SMBs including Na+ migration, desolvation, diffusion, nucleation, and deposition. The key influencing factors and optimization strategies of these behaviors are further summarized and discussed. More importantly, the high‐energy‐density anode‐free sodium metal batteries (AFSMBs) are highlighted by addressing key issues in the areas of limited Na sources and irreversible Na loss. Simultaneously, recent advanced characterization techniques for deeper insights into interfacial Na+ deposition behavior and composition information of SEI film are spotlighted to provide guidance for the advancement of SMBs and AFSMBs. Finally, the prominent perspectives are presented to guide and promote the development of SMBs and AFSMBs.
Standardized evaluation methodology for renal cortical blood perfusion in elderly patients using contrast‐enhanced ultrasound: A Chinese expert consensus (2024 edition)
Authors: Junhong Ren , Wen He 
Published: August 2024

AbstractAs a sensitive and non‐invasive method for assessing changes in renal cortical blood perfusion in the elderly, contrast‐enhanced ultrasound (CEUS) can indirectly reflect changes in kidney filtration and reabsorption function, thus providing feasibility for early evaluation of renal function changes. However, significant differences exist among researchers in terms of operational methods, contrast agent selection, post‐data analysis, and many other aspects, leading to substantial heterogeneity in results. This hinders horizontal comparisons and greatly limits the clinical application of contrast‐enhanced ultrasound for evaluating renal cortical blood flow perfusion. Based on the latest domestic and overseas literature and discussions with clinical experts, this consensus provides recommended guidelines for the evaluation of renal cortical blood flow perfusion using contrast‐enhanced ultrasound. It is hoped that this consensus will promote a better understanding of CEUS among medical practitioners at all levels and standardize the examination of renal cortical blood flow perfusion with CEUS.
Vitamin B12 status and skeletal muscle function among elderly: A literature review and pilot study on the effect of oral vitamin B12 supplementation in improving muscle function
Authors: Sharma Sowmya , Bhadra Rohini , Selvam Sumithra , Sambashivaiah Sucharita 
Published: August 2024

AbstractObjectivesThe objective of this study is to understand the role of vitamin B12 supplementation in improving skeletal muscle function among the elderly.MethodsA literature review in the Medline database was conducted to understand the association between vitamin B12 and muscle function in Section A. In Section B, 28 healthy elderly participants aged ≥60 years were recruited in a cross‐sectional design for estimation of plasma vitamin B12 status and assessment of upper limb muscle strength Maximal voluntary contraction (MVC) and muscle quality (expressed as MVC/total muscle mass). Participants were grouped based on vitamin B12 status into vitamin B12‐depleted (<148 pmol/L) and replete (≥148 pmol/L) groups. In a quasi‐experimental study design, the vitamin B12‐depleted group (n = 14) received daily oral vitamin B12 supplementation of 100 μg for 3 months. All the study measures were repeated post‐supplementation.ResultsVitamin B12 deficiency was identified to contribute adversely to muscle strength, quality, and physical performance among older people in the extensive literature review. The pilot intervention study showed significant improvement in MVC and muscle quality (p < 0.050) post‐vitamin B12 supplementation, comparable to the vitamin B12‐replete group.ConclusionsVitamin B12 may have a crucial role in the maintenance of muscle function. 3‐month oral vitamin B12 supplementation among subclinical vitamin B12 deficient elderly improved muscle strength and quality and reached levels similar to the vitamin B12 replete group.
Intra‐tumoral and peripheral blood TIGIT and PD‐1 as immune biomarkers in nodular lymphocyte predominant Hodgkin lymphoma
Authors: Gunawardana Jay , Law Soi C. , Sabdia Muhammed B. , Fennell Éanna , Hennessy Aoife , Leahy Ciara I. , Murray Paul G. , Bednarska Karolina , Brosda Sandra , Trotman Judith , Berkahn Leanne , Zaharia Andreea , Birch Simone , Burgess Melinda , Talaulikar Dipti , Lee Justina N. , Jude Emily , Hawkes Eliza A. , Jain Sanjiv , Nath Karthik , Snell Cameron , Swain Fiona , Tobin Joshua W. D. , Keane Colm , Shanavas Mohamed , Blyth Emily , Steidl Christian , Savage Kerry , Farinha Pedro , Boyle Merrill , Meissner Barbara , Green Michael R. , Vega Francisco , Gandhi Maher K. 
Published: August 2024

AbstractIn classical Hodgkin lymphoma (cHL), responsiveness to immune‐checkpoint blockade (ICB) is associated with specific tumor microenvironment (TME) and peripheral blood features. The role of ICB in nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is not established. To gain insights into its potential in NLPHL, we compared TME and peripheral blood signatures between HLs using an integrative multiomic analysis. A discovery/validation approach in 121 NLPHL and 114 cHL patients highlighted >2‐fold enrichment in programmed cell death‐1 (PD‐1) and T‐cell Ig and ITIM domain (TIGIT) gene expression for NLPHL versus cHL. Multiplex imaging showed marked increase in intra‐tumoral protein expression of PD‐1+ (and/or TIGIT+) CD4+ T‐cells and PD‐1+CD8+ T‐cells in NLPHL compared to cHL. This included T‐cells that rosetted with lymphocyte predominant (LP) and Hodgkin Reed–Sternberg (HRS) cells. In NLPHL, intra‐tumoral PD‐1+CD4+ T‐cells frequently expressed TCF‐1, a marker of heightened T‐cell response to ICB. The peripheral blood signatures between HLs were also distinct, with higher levels of PD‐1+TIGIT+ in TH1, TH2, and regulatory CD4+ T‐cells in NLPHL versus cHL. Circulating PD‐1+CD4+ had high levels of TCF‐1. Notably, in both lymphomas, highly expanded populations of clonal TIGIT+PD‐1+CD4+ and TIGIT+PD‐1+CD8+ T‐cells in the blood were also present in the TME, indicating that immune‐checkpoint expressing T‐cells circulated between intra‐tumoral and blood compartments. In in vitro assays, ICB was capable of reducing rosette formation around LP and HRS cells, suggesting that disruption of rosetting may be a mechanism of action of ICB in HL. Overall, results indicate that further evaluation of ICB is warranted in NLPHL.