bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accumulation of DNA G‐quadruplex in mitochondrial genome hallmarks mesenchymal senescence
Authors: Yu Kangkang , Li Feifei , Ye Ling , Yu Fanyuan 
Published: July 2024

AbstractSearching for biomarkers of senescence remains necessary and challenging. Reliable and detectable biomarkers can indicate the senescence condition of individuals, the need for intervention in a population, and the effectiveness of that intervention in controlling or delaying senescence progression and senescence‐associated diseases. Therefore, it is of great importance to fulfill the unmet requisites of senescence biomarkers especially when faced with the growing global senescence nowadays. Here, we established that DNA G‐quadruplex (G4) in mitochondrial genome was a reliable hallmark for mesenchymal senescence. Via developing a versatile and efficient mitochondrial G4 (mtG4) probe we revealed that in multiple types of senescence, including chronologically healthy senescence, progeria, and replicative senescence, mtG4 hallmarked aged mesenchymal stem cells. Furthermore, we revealed the underlying mechanisms by which accumulated mtG4, specifically within respiratory chain complex (RCC) I and IV loci, repressed mitochondrial genome transcription, finally impairing mitochondrial respiration and causing mitochondrial dysfunction. Our findings endowed researchers with the visible senescence biomarker based on mitochondrial genome and furthermore revealed the role of mtG4 in inhibiting RCC genes transcription to induce senescence‐associated mitochondrial dysfunction. These findings depicted the crucial roles of mtG4 in predicting and controlling mesenchymal senescence.
A systematic review of research examining mothers, infants, family and staff in psychiatric mother‐baby units
Authors: Adhikary Sam , Gillespie Kerri , Kimball Hayley , Healey Lyndall , Webb Olivia , Balram Abha , Branjerdporn Grace 
Published: July 2024

AbstractObjectiveThis systematic review aimed to summarise and synthesise research conducted in psychiatric mother‐baby units (MBUs) in relation to patients, their families, or staff, published from 1st January 2016 to 1st May 2024.MethodQuantitative, qualitative, and mixed‐method studies were included for review if they were published in peer‐review journals in English and reported research on MBUs between January 2016 and May 2024. From the initial yield of 10,007 unique studies, 53 studies were included for review.ResultsMBU research was found to more frequently investigate maternal characteristics rather than the benefits of MBU treatment compared to studies conducted prior to 2016. Most studies that did investigate impact of admission showed favourable results, however few follow‐up studies and studies comparing MBU outcomes to other clinical settings were undertaken. Little research has been conducted to investigate the differential impacts of MBU admission on different diagnoses and long‐term (>1 year) patient outcomes. There was a dearth of research investigating partners of women in MBUs and few studies conducted on infant outcomes.ConclusionsMBUs were consistently found to improve mental health systems and mother‐infant attachment in patients after admission. More research investigating patient support networks and child health, impact of diagnosis on outcomes, and studies with adequate follow‐up are required.
Seabird bycatch in European waters
Authors: Ramírez I. , Mitchell D. , Vulcano A. , Rouxel Y. , Marchowski D. , Almeida A. , Arcos J. M. , Cortes V. , Lange G. , Morkūnas J. , Oliveira N. , Paiva V. H. 
Published: July 2024

AbstractThe incidental capture (bycatch) of seabirds is a global conservation issue and a top threat to European species that demands urgent conservation and management action. Here, we present the first European review of seabird bycatch data, considering all fishing gears and data collection methods available in the region. We calculate seabird bycatch numbers per species, family, country and European marine region and assess the reliability of the data available. The cumulative bycatch estimate extracted from this review suggests that about 195,000 seabirds (ranging from around 130,000 to 380,000) are bycaught in European waters annually. The most affected seabird species is the Common Guillemot Uria aalge with over 31,000 birds killed per year. The marine region with the highest bycatch estimate is the Northeast Atlantic (over 115,000 seabirds year−1). Gillnet fisheries are responsible for the highest bycatch levels, with over 95,000 seabirds year−1, followed by longline fisheries. The families most affected by bycatch are Anatidae and Alcidae. These numbers are likely an underestimation since we were unable to find bycatch estimates, or to extrapolate estimates from available bycatch data for 12 (out of 34) European coastal states. Our assessment also identified significant data gaps in key areas such as Gran Sol (in the north‐east Atlantic), the central and Eastern Mediterranean and the Black Sea. Combining systematic data collection with immediate implementation of mitigation measures will be crucial to fill in knowledge gaps, reduce current mortality levels and meet international conservation commitments such as those of the European Union and the Convention on Migratory Species.
Supply chain digitalization and corporate ESG performance
Authors: Chen Siqian , Leng Xin , Luo Kun 
Published: July 2024

AbstractIn the wave of the digital economy, supply chain digitalization is a visual manifestation of businesses integrating digital technology into their production and operations. It helps companies enhance operational efficiency and competitiveness, gradually becoming a key driver for corporate sustainable development. This study selects Chinese A‐share listed companies from 2012 to 2021 as research samples and empirically tests the impact of supply chain digitalization on corporate environment (E), social responsibility (S), and corporate governance (G) (ESG) performance. We find that supply chain digitalization significantly promotes corporate ESG performance, which is achieved by reducing information asymmetry and easing financing constraints. The positive effect of supply chain digitalization on corporate ESG performance varies significantly among different enterprises, with more prominent effects in mature enterprises, those at both ends of the industrial chain, and those located in regions with lower degree of marketization. Further analysis reveals that supply chain digitalization brings about an innovation effect for enterprises. These findings enrich the research on supply chain digitalization and corporate ESG performance, providing valuable insights for promoting supply‐side structural reforms and corporate sustainable development.
Incidence and predictors of major gastrointestinal bleeding in patients on aspirin, low‐dose rivaroxaban, or the combination: Secondary analysis of the COMPASS randomised controlled trial
Authors: Forbes Nauzer , Yi Qilong , Moayyedi Paul , Bosch Jackie , Bhatt Deepak L. , Fox Keith A. A. , Eikelboom John W. 
Published: July 2024

SummaryBackgroundThe incidence of major gastrointestinal bleeding (GIB) in patients on low‐dose direct‐acting oral anticoagulants (DOACs) is relatively unknown. Estimates from randomised controlled trials (RCTs) are lacking.AimsTo assess GIB incidence and predictors from RCT data of patients on aspirin, low‐dose rivaroxaban, or both.MethodsThis was a secondary analysis of RCT data wherein patients received aspirin 100 mg daily and rivaroxaban 2.5 mg b.d., aspirin alone, or rivaroxaban 5 mg b.d. Patients were followed from 2013 to 2016 at 602 centres. Outcomes included overall, upper, and lower GIB. We employed multivariable logistic regression to yield odds ratios (ORs) and 95% confidence intervals for potential exposures.ResultsAmong 27,395 patients, the annual incidence of GIB on rivaroxaban 2.5 mg b.d. with aspirin was 801.7 per 100,000 compared with 372.3 in 100,000 for aspirin. Age (OR 4.16, 2.53–6.82 for ≥75 vs. 55–64), peptic ulcer disease (PUD, OR 1.57, 1.01–2.44), liver disease (OR 2.09, 1.01–4.33), hypertension (OR 1.42, 1.04–1.94), and smoking (OR 1.85, 1.26–2.73) were associated with overall GIB. Kidney disease (OR 1.68, 1.12–2.51) was significantly associated with upper GIB, whereas diverticular disease (OR 3.75, 1.88–7.49) was associated with lower GIB. Addition of rivaroxaban to aspirin was associated more with lower GIB (OR 2.82, 1.64–4.84) than upper GIB (OR 1.86, 1.18–2.92).ConclusionsWe established incidences and identified risk factors for GIB in users of low‐dose DOACs. Novel risk factors included current or former smoking and diverticulosis. Future studies should aim to validate these risk factors.
ArchaeoPyDating: A new user‐friendly release for archaeomagnetic dating
Authors: Serrano Mario , Pavón‐Carrasco F. Javier , Campuzano Saioa A. , Osete M. Luisa 
Published: July 2024

AbstractIn this work, we present ArchaeoPyDating, a new version of the archaeo_dating Matlab software used for archaeomagnetic dating. This updated version introduces a transition from the original Matlab code to Python, enabling the software to be presented as an online tool. By offering a web‐based interface, ArchaeoPyDating eliminates the need for licenses, program installations, or programming expertise, making it widely accessible to users through various devices and browsers. This enhanced accessibility holds great potential for popularizing the archaeomagnetic dating method. This study presents both the new online version of the tool and a Python module that encompasses all the essential classes and functions required for conducting archaeomagnetic dating in a command‐line environment, which can be useful for advanced users.
Marsden as organization theorist
Authors: Salesina Marc 
Published: July 2024

AbstractI argue that David Marsden, lauded in Employment Relations (ER) and Human Resource Management, deserves recognition as an organization theorist. Viewing his works as a unified theory, I demonstrate how his focus on the interaction between individual actions, institutions and organizational structures aligns with the fields core concerns. Further, I apply an organizational dialectics approach to his analysis of organizational tensions like managerial authority and diffusion of employment systems. This reinterpretation offers new insights into organizational structure and design and the importance of ER‐specific factors and processes in shaping them. It highlights the enduring value of Marsden's framework for understanding organizations.
Canadian settler colonialism: Structure, event, relationship, or process?
Authors: Bernauer Warren 
Published: July 2024

AbstractGeography scholarship examining Canadian colonialism often draws upon concepts and categories from the field of Settler Colonial Studies, including Patrick Wolfe's definition of settler colonialism as a “structure rather than an event.” In this brief intervention, I argue that historical Marxist debates about structuralism and social class have important lessons for the way geographers characterize Canadian colonialism today. The definition of class as both relationship and process is especially relevant, because Indigenous intellectuals and activists tend to speak about (de)colonization in similar terms. By reframing Canadian colonialism as relationship and process rather than structure, we can better engage Indigenous criticisms of Settler Colonial Studies, understandings of (de)colonization, and epistemologies and ontologies.
Efficacy of surgical treatments for the management of solitary rectal ulcer syndrome: a network meta‐analysis
Authors: Gaj Fabio , Lai Quirino , Gelormini Enza , Ceci Marino , Di Saverio Salomone , Quaresima Silvia 
Published: July 2024

AbstractAimSolitary rectal ulcer syndrome (SRUS) is a benign and poorly understood disorder with complex management. Typical symptoms include straining during defaecation, rectal bleeding, tenesmus, mucoid secretion, anal pain and a sense of incomplete evacuation. Diagnosis is based on characteristic clinical symptoms and endoscopic/histological findings. Several treatments have been reported in the literature with variable ulcer healing rates. This study aimed to evaluate the efficacy of different treatments for SRUS.Materials and methodsA systematic review and network meta‐analysis were performed according to the PRISMA guidelines. Studies in English, French and Spanish languages were included. Papers written in other languages were excluded. Other exclusion criteria were reviews, case reports or clinical series enrolling less than five patients, study duplications, no clinical data of interest and no article available. A systematic literature search was conducted from January 2000 to March 2024 using the following databases: PubMed/MEDLINE, Cochrane Central Register of Controlled Trials, the Cochrane Database of Systematic Reviews, and Scopus. The biases of the studies were assessed using the Newcastle–Ottawa scale or the Jadad scale when appropriate. Types of treatment and their efficacy for the cure of SRUS were collected and critically assessed. The study's primary outcome was to estimate the rate of patients with ulcer healing.ResultsA total of 22 studies with 911 patients (men 361, women 550) diagnosed with SRUS were analysed in the final meta‐analysis. The pooled effect estimates of treatment efficacy revealed that surgery showed the highest ulcer healing rate (70.5%; 95% CI 0.57–0.83). Surgery was superior in the cure of ulcers with respect to medical therapies and biofeedback (OR 0.09 and OR 0.14).ConclusionSolitary rectal ulcer syndrome is a challenging clinical entity to manage. Proficient results have been reported with the surgical approach, suggesting its positive role in cases refractory to medical and biofeedback therapy. Further studies in homogeneous populations are required to evaluate the efficacy of surgery in this setting. (PROSPERO registration number CRD42022331422).
Colonialism, Genocide and Reparations: The German‐Namibian Case
Authors: Melber Henning 
Published: July 2024

ABSTRACTIn 2015 the German government acknowledged that the Empire committed genocide in its colony South West Africa, known since its independence as Namibia. This acknowledgement marked a new reference point in how to engage with colonial crimes. Since then, Germany has fallen short of bearing full and unconditional responsibility for and recognition of the crime in terms of restorative justice. While Germany deserves credit for its commemoration and remorse over the Holocaust during World War II, victims of other forms of extermination with the intent to destroy still crave adequate recognition, commemoration and compensation in the form of reparations. This article presents the Namibian case to illustrate the contradictions and limitations that emerge when general notions are tested and undermined by asymmetric power relations of Realpolitik.
Improving processing speed in adolescents at clinical high risk for psychosis with the Specific COgnitive REmediation plus Surround (SCORES) intervention: Study protocol
Authors: Carrión Ricardo E. , Auther Andrea M. , McLaughlin Danielle , John Majnu , Cornblatt Barbara A. 
Published: July 2024

AbstractAimRecent preventative approaches with young people at clinical high risk for psychosis (CHR‐P) have focused on the remediation of the cognitive deficits that are readily apparent and predictive of future illness. However, the small number of trials using cognitive remediation with CHR‐P individuals have reported mixed results. The proposed 2‐phased study will test an innovative internet‐based and remotely‐delivered Specific COgnitive REmediation plus Surround (or SCORES) intervention that targets early processing speed deficits in CHR‐P adolescents aged 14–20 years old.MethodsIn the first R61 phase, a single‐arm 2‐year proof of concept study, 30 CHR‐P individuals will receive SCORES for 10 weeks (4 h per week/40 h total) with a midpoint assessment at 20 h (5 weeks) to demonstrate target engagement and identify the optimal dose needed to engage the target. The Go/No‐Go criteria to move to the R33 phase will be processing speed scores improving by a medium effect size (Cohen's d ≥ .6). The proposed package includes a set of complimentary support surround procedures to increase enjoyment and ensure that participants will complete the home‐based training. In the second R33 phase, a 3‐year pilot study, we will replicate target engagement in a new and larger sample of 54 CHR‐P individuals randomized to SCORES (optimized dose) or to a video game playing control condition. In addition, the R33 phase will determine if changes in processing speed are associated with improved social functioning and decreasing attenuated positive symptoms. The support surround components of the intervention will remain constant across phases and conditions in the R33 phase to firmly establish the centrality of processing speed training for successful remediation.ConclusionsThe SCORES study is a completely virtual intervention that targets a core cognitive mechanism, processing speed, which is a rate‐limiting factor to higher order behaviours and clinical outcomes in CHR‐P adolescents. The virtual nature of this study should increase feasibility as well improve the future scalability of the intervention with considerable potential for future dissemination as a complete treatment package.
A unified creep and fatigue life prediction approach for 316 austenitic stainless steel using machine and deep learning
Authors: Bhardwaj Harsh Kumar , Shukla Mukul 
Published: July 2024

Abstract316 Austenitic stainless steel (AusSS) is extensively utilized in high‐temperature industrial applications such as boiler tubes and nuclear reactor pressure vessels. These components commonly experience failure under high‐temperature and high‐pressure conditions, attributed to either creep or fatigue. Existing classical models for creep and fatigue life prediction focus on a singular failure mode (either creep or fatigue) and consider physical features only. This study aims to develop a unified life prediction model for both creep and fatigue phenomena. It synthesizes information from 12 additional unexplored chemical and microstructural features from the National Institute of Materials Science (NIMS), Japan database, and previously published literature. Machine learning (such as decision tree, random forest, and XGBoost) and deep learning (like deep neural network) algorithms are employed in the modeling process. The trained models have been cross‐validated against unseen creep and fatigue life data, demonstrating superior prediction accuracy of 96.1% for deep neural network compared with classical models.
Intralesional hyaluronidase injection to relieve non‐hyaluronic acid filler‐induced vascular adverse events
Authors: Kadouch Jonathan , Schelke Leonie , Groh Olivier , Sokol Vicky , Velthuis Peter 
Published: July 2024

AbstractBackgroundVascular adverse events (VAEs) occurring during injections of soft‐tissue fillers are still considered a challenging issue for both patients and practitioners. Hyaluronidase can dissolve hyaluronic acid (HA)‐based soft‐tissue fillers during a VAE. For VAEs induced by non‐HA fillers, the absence of an “antidote” is regarded as exceptionally challenging.MethodsThis multicenter study describes a case series of three VAEs induced by non‐HA fillers, for which ultrasound‐guided hyaluronidase injections were incorporated into the treatment approach.ResultsTwo cases of calcium hydroxylapatite and one case of poly‐L‐lactic acid‐induced VAEs are described, all of which were resolved without necrosis or scarring using a treatment approach with ultrasound‐guided hyaluronidase injections.ConclusionsUnlike the mechanical hypothesis, which assumes filler particles travel antegrade to block arterioles in a large skin area, we hypothesize vasoconstriction as the pivot in VAEs. Filler injection‐induced spasms could lead to long‐lasting vasoconstriction of the perforator arteries stemming from the central facial arteries. Our results underscore that perforasome vasoconstriction might be the leading cause of the ischemia and subsequent necrosis in VAEs and that relaxation of these perforasomes, rather than dissolving the filler material, resolves the clinical symptoms associated with VAEs.
Economic Burden of Medically Attended Respiratory Syncytial Virus Infections Among Privately Insured Children Under 5 Years of Age in the USA
Authors: Tran Phuong T. , Nduaguba Sabina O. , Wang Yanning , Diaby Vakaramoko , Finelli Lynn , Choi Yoonyoung , Winterstein Almut G. 
Published: July 2024

ABSTRACTBackgroundThe cost of medically attended RSV LRI (lower respiratory infection) is critical in determining the economic value of new RSV immunoprophylaxes. However, most studies have focused on intermittent RSV encounters, not the episode of care that captures the entirety of RSV illness.MethodsWe created age‐ and condition‐specific cohorts of children under 5 years of age using MarketScan® data (2015–2019). We contrasted aggregating healthcare costs over RSV‐LRTI episodes to ascertaining costs based on RSV‐specific encounters only. Economic burden was estimated by multiplying costs per encounter or per episode by their respective incidence rates.ResultsAverage cost was higher per episode than per encounter regardless of settings (inpatient: $28,586 vs. $18,056 and outpatient/ED: $2099 vs. $407 for infants). Across ages, the economic burden was highest for infants and RSV‐LRTI requiring inpatient care, but the burden in outpatient/ED settings was disproportionately higher than costs due to higher incidence rates (for inpatient vs. outpatient episodes: $226,403 vs. $101,269; for inpatient vs. outpatient encounters: $151,878 vs. $38,819 per 1000 infant‐years). For high‐risk children, cost and burden were up to 3–10 times higher, respectively.ConclusionsWith a comprehensive stratification by settings and risk condition, the encounter‐ versus episode‐based estimates provide a robust range for policymakers' economic appraisal of new RSV immunoprophylaxes.