bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of different tooth movement patterns and aligner thicknesses on maxillary arch expansion with clear aligners: a three-dimensional finite element study
Authors: Li Na , Wang ChunJuan , Yang Min , Chen DingGen , Tang MingYuan , Li DaoKun , Qiu ShengLei , Chen Qi , Feng Yi 
Published: June 2024

ObjectivesThe objective of this study was to investigate the biomechanical effects of different tooth movement patterns and aligner thicknesses on teeth and periodontal tissues during maxillary arch expansion with clear aligners, to facilitate more precise and efficient clinical orthodontic treatments.MethodsThree-dimensional models including teeth, maxilla, periodontal ligament, and aligner were constructed and subjected to finite element analysis. Tooth displacement trends and periodontal ligament stresses were measured for seven tooth displacement patterns (divided into three categories including overall movement of premolars and molars with gradually increasing molar expansion in each step; distributed movement of premolars and molars; and alternating movement between premolars and molars at intervals) and two aligner thicknesses (0.5 mm and 0.75 mm) during maxillary arch expansion with clear aligners.ResultsWhen expanding the maxillary arch with clear aligners, the effective expansion of the target teeth mainly showed a tilting movement trend. Increasing the amount of molar expansion increased the buccal displacement of the first molar but decreased the buccal displacement of the premolars. The mean buccal displacement of the target teeth was greater in the posterior teeth interval alternating movement group (0.026 mm) than in the premolar/molar distributed movement group (0.016 mm) and the overall movement group (0.015 mm). Increasing aligner thickness resulted in greater buccal displacement of the crowns and increased stress on the periodontal ligaments.ConclusionIncreasing the amount of molar expansion reduces the efficiency of premolar expansion. Alternating movement of premolars and molars at intervals achieves a higher arch expansion efficiency, but attention should be paid to the anchorage of adjacent teeth. Increasing the thickness of the aligner increases the expansion efficiency but may also increase the burden on the periodontal tissues.
Screening of potentially active compounds against rheumatoid arthritis in the Juan-Bi decoction using systems pharmacology and animal experiments
Authors: Liu Dahai , Fu Qiang , Liu Leyna G. , Li Wenwen , Qi Fei , Liu Justin , Shang Lifeng , Wang Xiu , Yang Fang , Li Jie , Lu Daoqiang , Feng Huiying , Zhang Ziwen , Chen Yiqing , Liang Junru , Yao Jiayi , Lv Hua , Li Riwang , Wang Jun , Wu Di , Liu Yuxi , Xia Chenglai , Li Wenxing 
Published: June 2024

Background: The Juan-Bi decoction (JBD) is a classic traditional Chinese medicines (TCMs) prescription for the treatment of rheumatoid arthritis (RA). However, the active compounds of the JBD in RA treatment remain unclear.Aim: The aim of this study is to screen effective compounds in the JBD for RA treatment using systems pharmacology and experimental approaches.Method: Botanical drugs and compounds in the JBD were acquired from multiple public TCM databases. All compounds were initially screened using absorption, distribution, metabolism, excretion, and toxicity (ADMET) and physicochemical properties, and then a target prediction was performed. RA pathological genes were acquired from the DisGeNet database. Potential active compounds were screened by constructing a compound–target–pathogenic gene (C-T-P) network and calculating the cumulative interaction intensity of the compounds on pathogenic genes. The effectiveness of the compounds was verified using lipopolysaccharide (LPS)-induced RAW.264.7 cells and collagen-induced arthritis (CIA) mouse models.Results: We screened 15 potentially active compounds in the JBD for RA treatment. These compounds primarily act on multiple metabolic pathways, immune pathways, and signaling transduction pathways. Furthermore, in vivo and in vitro experiments showed that bornyl acetate (BAC) alleviated joint damage, and inflammatory cells infiltrated and facilitated a smooth cartilage surface via the suppression of the steroid hormone biosynthesis.Conclusion: We screened potential compounds in the JBD for the treatment of RA using systems pharmacology approaches. In particular, BAC had an anti-rheumatic effect, and future studies are required to elucidate the underlying mechanisms.
Impact of coronary collateralization on major adverse cardiovascular and cerebrovascular events after successful recanalization of chronic total occlusion
Authors: Sun Yurong , Zhang Bin , Zhang Xinyuan , Zhang Xiaojiao , Bao Wenqi , Bai Hangrui , Luan Bo 
Published: June 2024

AimsThis study aims to investigate the effects of coronary collateral circulation (CCC) on the prognosis of chronic total occlusion (CTO) patients with or without metabolic syndrome (MetS).MethodsThe study included 342 CTO patients who underwent successful percutaneous coronary intervention at the People's Hospital of Liaoning Province between 1 February 2021 and 30 September 2023. The Rentrop score was used to assess the status of CCC. The outcome was major adverse cardiovascular and cerebrovascular events (MACCEs), defined as a composite of all-cause mortality, cardiac death, non-fatal myocardial infarction (MI), target vessel revascularization (TVR), and non-fatal stroke. Univariate and multivariate logistic analyses were used to investigate the association of CCC, MetS, and MACCEs with odds ratios (ORs) and 95% confidence intervals (CIs). The effect of CCC was further investigated in different MetS, diabetes mellitus (DM), and Syntax score groups.ResultsMACCEs were more common in patients with poor CCC compared to those with good CCC (38.74% vs. 16.56%). Statistical differences were found in MACCEs (OR = 3.33, 95% CI: 1.93–5.72), MI (OR = 3.11, 95% CI: 1.73–5.58), TVR (OR = 3.06, 95% CI: 1.70–5.53), and stent thrombosis (OR = 6.14, 95% CI: 2.76–13.65) between the good and poor CCC groups. Poor CCC patients with MetS had a higher incidence of MACCEs (OR = 4.21, 95% CI: 2.05–8.65), non-fatal MI (OR = 4.44, 95% CI: 2.01–9.83), TVR (OR = 3.28, 95% CI: 1.51–7.11), and stent thrombosis (OR = 10.80, 95% CI: 3.11–37.54). Similar findings were also observed in CTO patients with DM and a Syntax score ≥23.ConclusionPoor CCC could increase the risk of MACCEs in CTO patients, particularly those with MetS, DM, and a Syntax score ≥23. Further prospective, multicenter studies are needed to validate our findings and to explore potential therapeutic interventions.
Heavy metals in wastewater and fish collected from waste stabilization pond and human health risks in southwestern Ethiopia
Authors: Berhanu Girma , Lemma Hailu , Mekonnen Seblework , Dadi Dessalegn 
Published: June 2024

IntroductionThis study aimed to measure the concentration of toxic heavy metals in wastewater samples and Nile tilapia (Oreochromis niloticus) species inhabiting wastewater (waste stabilization ponds) and evaluate their safety as a food source in southwestern Ethiopia. For this purpose, toxic metals like lead (Pb), cadmium (Cd), arsenic (As), and mercury (Hg) in wastewater samples and fish tissues (muscle, gill, and liver) were independently examined.MethodsA laboratory-based cross-sectional study was performed to ascertain the levels of Pb, Cd, As, and Hg in the fish tissues ofO. niloticusand wastewater samples. Heavy metal levels were analyzed by microplasma atomic emission spectrometry (Agilent 4210 MP-AES) and hydrogen-generated atomic absorption spectrometry (HGAAS, novAA 400P, Germany).ResultsHeavy metal concentrations were measured in the following decreasing order (µg L−1): Cd &gt; Pb &gt; As &gt; Hg in facultative and maturation ponds, with Cd (27.66 µg L−1) having the highest concentration and Hg (0.349 µg L−1) having the lowest concentration. Among the heavy metals detected in the wastewater samples, Hg showed a statistically significant difference between the sampling points (p = 0.023). The maximum metal concentration was measured for Pb (0.35 mg kg−1) and Cd (0.24 mg kg−1) in the muscle tissue ofO. niloticus. The value of arsenic (0.02 mg kg−1) detected in fish edible muscles exceeded the FAO/WHO maximum permissible limit (MPL = 0.01) for human consumption. The carcinogenic and non-carcinogenic health risks of consuming fish due to trace metals were relatively low and posed fewer potential threats to human health. According to this finding, children were more susceptible to heavy metal exposure than adults.ConclusionDue to the high quantities of these harmful heavy metals, wastewater from oxidation ponds should not be used for fishing to avoid bioaccumulation. The target carcinogenic risk (TR) and target hazard quotient (THQ) indicated that all heavy metals were below the safe threshold. This research will provide a baseline for monitoring trace metals in various edible aquatic creatures and for future research in artificial habitats and regulatory considerations.
Altered ontogeny and transcriptomic signatures of tissue-resident pulmonary interstitial macrophages ameliorate allergic airway hyperresponsiveness
Authors: Tighe Robert M. , Birukova Anastasiya , Malakhau Yuryi , Kobayashi Yoshihiko , Vose Aaron T. , Chandramohan Vidya , Cyphert-Daly Jaime M. , Cumming R. Ian , Fradin Kirshner Helene , Tata Purushothama R. , Ingram Jennifer L. , Gunn Michael D. , Que Loretta G. , Yu Yen-Rei A. 
Published: June 2024

IntroductionEnvironmental exposures and experimental manipulations can alter the ontogenetic composition of tissue-resident macrophages. However, the impact of these alterations on subsequent immune responses, particularly in allergic airway diseases, remains poorly understood. This study aims to elucidate the significance of modified macrophage ontogeny resulting from environmental exposures on allergic airway responses to house dust mite (HDM) allergen.MethodsWe utilized embryonic lineage labeling to delineate the ontogenetic profile of tissue-resident macrophages at baseline and following the resolution of repeated lipopolysaccharide (LPS)-induced lung injury. We investigated differences in house dust mite (HDM)-induced allergy to assess the influence of macrophage ontogeny on allergic airway responses. Additionally, we employed single-cell RNA sequencing (scRNAseq) and immunofluorescent staining to characterize the pulmonary macrophage composition, associated pathways, and tissue localization.ResultsOur findings demonstrate that the ontogeny of homeostatic alveolar and interstitial macrophages is altered after the resolution from repeated LPS-induced lung injury, leading to the replacement of embryonic-derived by bone marrow-derived macrophages. This shift in macrophage ontogeny is associated with reduced HDM-induced allergic airway responses. Through scRNAseq and immunofluorescent staining, we identified a distinct subset of resident-derived interstitial macrophages expressing genes associated with allergic airway diseases, localized adjacent to terminal bronchi, and diminished by prior LPS exposure.DiscussionThese results suggest a pivotal role for pulmonary macrophage ontogeny in modulating allergic airway responses. Moreover, our findings highlight the implications of prior environmental exposures in shaping future immune responses and influencing the development of allergies. By elucidating the mechanisms underlying these phenomena, this study provides valuable insights into potential therapeutic targets for allergic airway diseases and avenues for further research into immune modulation and allergic disease prevention.
Exploring the role of anticipatory postural adjustment duration within APA2 subphase as a potential mediator between clinical disease severity and fall risk in Parkinson’s disease
Authors: Hu Cheng-Hao , Lai Yun-Ru , Huang Chih-Cheng , Lien Chia-Yi , Chen Yueh-Sheng , Yu Chiun-Chieh , Lee Sieh-Yang , Lin Wei-Che , Cheng Ben-Chung , Chiu Wen-Chan , Chiang Yi-Fang , Kung Chien-Feng , Lu Cheng-Hsien 
Published: June 2024

IntroductionPeople with Parkinson’s Disease (PD) often show reduced anticipatory postural adjustments (APAs) before voluntary steps, impacting their stability. The specific subphase within the APA stage contributing significantly to fall risk remains unclear.MethodsWe analyzed center of pressure (CoP) trajectory parameters, including duration, length, and velocity, throughout gait initiation. This examination encompassed both the postural phase, referred to as anticipatory postural adjustment (APA) (APA1, APA2a, APA2b), and the subsequent locomotor phases (LOC). Participants were instructed to initiate a step and then stop (initiating a single step). Furthermore, we conducted assessments of clinical disease severity using the Unified Parkinson’s Disease Rating Scale (UPDRS) and evaluated fall risk using Tinetti gait and balance scores during off-medication periods.ResultsFreezing of gait (FOG) was observed in 18 out of 110 participants during the measurement of CoP trajectories. The Ramer-Douglas-Peucker algorithm successfully identified CoP displacement trajectories in 105 participants (95.5%), while the remaining 5 cases could not be identified due to FOG. Tinetti balance and gait score showed significant associations with levodopa equivalent daily dose, UPDRS total score, disease duration, duration (s) in APA2a (s) and LOC (s), length in APA1 (cm) and APA2b (cm), mediolateral velocity in APA1 (X) (cm/s), APA2a (X) (cm/s), APA2b (X) (cm/s) and LOC (X) (cm/s), and anterior–posterior velocity in APA2a (Z) (cm/s) and APA2b (Z) (cm/s). Multiple linear regression revealed that only duration (s) in APA2a and UPDRS total score was independently associated with Tinetti gait and balance score. Further mediation analysis showed that the duration (s) in APA2a served as a mediator between UPDRS total score and Tinetti balance and gait score (Sobel test, p = 0.047).ConclusionAPA2 subphase duration mediates the link between disease severity and fall risk in PD, suggesting that longer APA2a duration may indicate reduced control during gait initiation, thereby increasing fall risk.
Validation and refinement of a predictive nomogram using artificial intelligence: assessing in-hospital mortality in patients with large hemispheric cerebral infarction
Authors: Ding Jian , Ma Xiaoming , Huang Wendie , Yue Chunxian , Xu Geman , Wang Yumei , Sheng Shiying , Liu Meng , Ren Yi 
Published: June 2024

BackgroundLarge Hemispheric Infarction (LHI) poses significant mortality and morbidity risks, necessitating predictive models for in-hospital mortality. Previous studies have explored LHI progression to malignant cerebral edema (MCE) but have not comprehensively addressed in-hospital mortality risk, especially in non-decompressive hemicraniectomy (DHC) patients.MethodsDemographic, clinical, risk factor, and laboratory data were gathered. The population was randomly divided into Development and Validation Groups at a 3:1 ratio, with no statistically significant differences observed. Variable selection utilized the Bonferroni-corrected Boruta technique (p &lt; 0.01). Logistic Regression retained essential variables, leading to the development of a nomogram. ROC and DCA curves were generated, and calibration was conducted based on the Validation Group.ResultsThis study included 314 patients with acute anterior-circulating LHI, with 29.6% in the Death group (n = 93). Significant variables, including Glasgow Coma Score, Collateral Score, NLR, Ventilation, Non-MCA territorial involvement, and Midline Shift, were identified through the Boruta algorithm. The final Logistic Regression model led to a nomogram creation, exhibiting excellent discriminative capacity. Calibration curves in the Validation Group showed a high degree of conformity with actual observations. DCA curve analysis indicated substantial clinical net benefit within the 5 to 85% threshold range.ConclusionWe have utilized NIHSS score, Collateral Score, NLR, mechanical ventilation, non-MCA territorial involvement, and midline shift to develop a highly accurate, user-friendly nomogram for predicting in-hospital mortality in LHI patients. This nomogram serves as valuable reference material for future studies on LHI patient prognosis and mortality prevention, while addressing previous research limitations.
Evaluation of the diagnostic and prognostic clinical values of circulating tumor DNA and cell-free DNA in pancreatic malignancies: a comprehensive meta-analysis
Authors: Arayici Mehmet Emin , İnal Abdullah , Basbinar Yasemin , Olgun Nur 
Published: June 2024

BackgroundThe diagnostic and prognostic clinical value of circulating tumor DNA (ctDNA) and cell-free DNA (cfDNA) in pancreatic malignancies are unclear. Herein, we aimed to perform a meta-analysis to evaluate ctDNA and cfDNA as potential diagnostic and prognostic biomarkers.MethodsPRISMA reporting guidelines were followed closely for conducting the current meta-analysis. The PubMed/Medline, Scopus, and Web of Science (WoS) databases were scanned in detail to identify eligible papers for the study. A quality assessment was performed in accordance with the REMARK criteria. The risk ratios (RRs) of the diagnostic accuracy of ctDNA compared to that of carbohydrate antigen 19.9 (CA 19.9) in all disease stages and the hazard ratios (HRs) of the prognostic role of ctDNA in overall survival (OS) were calculated with 95% confidence intervals (CIs).ResultsA total of 18 papers were evaluated to assess the diagnostic accuracy and prognostic value of biomarkers related to pancreatic malignancies. The pooled analysis indicated that CA19.9 provides greater diagnostic accuracy across all disease stages than ctDNA or cfDNA (RR = 0.64, 95% CI: 0.50–0.82, p &lt; 0.001). Additionally, in a secondary analysis focusing on prognosis, patients who were ctDNA-positive were found to have significantly worse OS (HR = 2.00, 95% CI: 1.51–2.66, p &lt; 0.001).ConclusionThe findings of this meta-analysis demonstrated that CA19-9 still has greater diagnostic accuracy across all disease stages than KRAS mutations in ctDNA or cfDNA. Nonetheless, the presence of detectable levels of ctDNA was associated with worse patient outcomes regarding OS. There is a growing need for further research on this topic.Systematic review registrationhttps://doi.org/10.37766/inplasy2023.12.0092, identifier INPLASY2023120092.
Consistent decrease in conifer embolism resistance from the stem apex to base resulting from axial trends in tracheid and pit traits
Authors: Zambonini Dario , Savi Tadeja , Rosner Sabine , Petit Giai 
Published: June 2024

IntroductionDrought-induced embolism formation in conifers is associated with several tracheid and pit traits, which vary in parallel from stem apex to base. We tested whether this axial anatomical variability is associated with a progressive variation in embolism vulnerability along the stem from apex to base.MethodsWe assessed the tracheid hydraulic diameter (Dh), mean pit membrane area (PMA) and the xylem pressure at 50% loss of conductivity (P50) on longitudinal stem segments extracted at different distances from the stem apex (DFA) in a Picea abies and an Abies alba tree.ResultsIn both trees, Dh and PMA scaled with DFA0.2. P50 varied for more than 3 MPa from the treetop to the stem base, according to a scaling of -P50 with DFA-0.2. The largest Dh, PMA and P50 variation occurred for DFA&lt;1.5 m. PMA and Dh scaled more than isometrically (exponent b=1.2). Pit traits vary proportionally with tracheid lumen diameter.Discussion and conclusionsApex-to-base trends in tracheid and pit traits, along with variations in P50, suggest a strong structure-function relationship that is influenced by DFA. Although the effect of DFA on P50 has not been extensively explored previously, we propose that analyzing the relationship between P50 and DFA could be crucial for a comprehensive assessment of embolism vulnerability at the individual level.
The impact of COVID-19 post-infection on the cognition of adults from Peru
Authors: Zegarra-Valdivia Jonathan , Arana-Nombera Harold , Perez-Fernandez Leandro , Alamo-Medina Reyna , Casimiro Milagros del Rocío , Bustamante-Delgado Diana , Matallana-Sanchez Maribel , Gallegos-Manayay Viviana , Álvarez-Bravo Elizabeth , Arteaga-Cancino Tihany , Abanto-Saldaña Eduardo , Oliva-Piscoya María del Rosario , Cruz-Ordinola María Celinda , Chavarry Patricia , Chino-Vilca Brenda , Paredes-Manrique Carmen , Chirinos Carlos , Custodio Nilton , Ibañez Agustín 
Published: June 2024

IntroductionThe COVID-19 pandemic, with over 83 million confirmed cases and 1.8 million deaths, has raised concerns about long-term cognitive issues, especially in populations facing disparities. Despite a few years since Peru’s first COVID-19 wave, the cognitive effects on adults remain unclear. This study is the first in Peru to explore COVID-19’s impact on general cognition and executive function.MethodsA retrospective cross-sectional study compared individuals with COVID-19 history to controls, assessing general cognition, verbal fluency, attention, and executive function. Among 240 assessed, 154 met the study inclusion criteria, with about 60% female and an average age of 38.89 ± 16.001 years. Groups included controls (n = 42), acute phase (AP, n = 74) (1–14 days of symptoms), and hyperinflammatory phase (HP, n = 38) (&gt;14 days of symptoms).ResultsSignificant cognitive differences were observed. The HP group exhibited lower general cognitive performance (p = 0.02), working memory (p = 0.01), and executive function (planning; p &lt; 0.001; flexibility; p = 0.03) than controls. Those with &lt;14 days of illness (AP vs. HP) had deficits in general cognitive performance (p = 0.02), working memory (p = 0.02), and planning (p &lt; 0.001), mainly during the hyperinflammatory phase, showing differences in working memory (p = 0.003) and planning (p = 0.01). Gender differences emerged, with males in the HP phase having poorer working memory (p = 0.003) and planning (p = 0.01).DiscussionThis study underscores COVID-19’s negative impact on cognitive function, even in mild cases, with potential heightened effects in men during acute or hyperinflammatory phases. The findings provide Peru’s first evidence, highlighting the vulnerability of populations facing socioeconomic disparities.
The relationship between self-oriented perfectionism and exercise participation: based on the dualistic model of passion
Authors: Zhang Weipeng , Zhu Yuanjiao , Jiang Feng , Song Huitao 
Published: June 2024

BackgroundDuring the critical formative years of college, active participation in sports not only helps to alleviate stress, but also promotes the development of healthy habits. Although the multifaceted benefits of exercise have been widely recognized, there is a relative dearth of research on the relationship between personality traits, particularly college students’ self-oriented perfectionism (SOP), and exercise participation.MethodsA questionnaire survey of 374 college students was conducted using the snowball sampling method. SPSS 26.0 and Mplus 8.3 were employed in this study to analyze the correlations between the variables, and on this basis, the effect of SOP on exercise participation was examined. The study also used 5,000 bootstrap samples and a 95% bias-corrected confidence interval to test the significance of the mediating effects.ResultsCorrelation analysis showed that SOP was positively correlated with exercise participation. Harmonious passion and obsessive passion were positively correlated with SOP, and exercise participation. Further, the results of structural equation analysis revealed that SOP increased exercise participation. Harmonious passion and obsessive passion positively mediated the effect between SOP and exercise participation, respectively.ConclusionThis study provides new perspectives to better understand college students’ exercise participation, emphasizing the importance of SOP and its influence on exercise participation through harmonious and obsessive passions. These findings have important implications for the development of effective exercise promotion strategies.