bluuebunny/crossref_metadata_2025_split huggingface dataset:
Apoptotic Cell Death of Neutrophils in Development of Skin Lesions of Patients with Anaphylactoid Purpura
Authors: Banno Sumiyo , Tamada Yasuhiko , Matsumoto Yoshinari , Ohashi Masaru 
Published: April 2015

AbstractThe participation of apoptotic cell death of neutrophils in the development of skin lesions of patients with anaphylactoid purpura was examined by the in situ specific labeling of fragmented DNA. In the early stage of the skin lesions, there were few positively stained nuclei in infiltrating cells. The number of positive cells increased markedly in the fully developed stage of the lesions. A number of neutrophils were stained positively. Finally, a few fragmented nuclei were still positive in the late stage of the lesions. It was therefore suggested that fragmentation of neutrophils in the skin lesions from the patients might be due to apoptosis. Inducible nitric oxide synthase and nitrotyrosine were detected in infiltrates, and interleukin‐8 was also detected in vascular endothelial cells in those skin lesions. The roles of nitric oxide and interleukin‐8 in the apoptosis of neutrophils are discussed.
Extensive Facial Strawberry Mark Associated with Cerebellar Hypoplasia and Vascular Abnormalities
Authors: Matsui Tamano , Ono Tomomichi , Kito Masato , Yoshioka Susumu , Ikeda Tetsuo 
Published: April 2015

AbstractStrawberry mark is considered a benign hemangioma with a tendency toward spontaneous regression and a benign prognosis (1). Recently, some papers have reported complications of large facial strawberry marks (2–6). We report a infant girl with an extensive strawberry mark on the left side of the face associated with ipsilateral cerebellar hypoplasia and Dandy‐Walker malformation. Abnormal branching of the aortic arch was also found.
Leiomyoblastoma and Leiomyomatosis of the Small Intestine in a Case of von Recklinghausen's Disease
Authors: Hamanaka Sumiko , Hamanaka Yuichiro , Yamashita Yoshimi , Otsuka Fujio 
Published: April 2015

AbstractA 70‐year‐old patient with von Recklinghausen's neurofibromatosis 1 (NF1) developed a stomach ulcer and underwent a total gasterectomy. During the laparotomy, a leiomyoblastoma and multiple leiomyomas, which were histologically diagnosed as such later, were found in the small intestine and resected. It is quite possible that the association of gastrointestinal leiomyomas and NF1 is more than coincidental. It is thus important to take this complication into account in clinical treatment of patients with NF1.
Effects of Thallium Ion on Cellular Components of the Skin
Authors: Arbiser Jack L. , Alani Rhoda , Flynn Evelyn , Wooten Virginia , Byers Hugh Randolph 
Published: April 2015

AbstractThallium salts have been employed by dermatologists to cause depilation, and dermatologic features are prominent in thallium overdose. These features include alopecia and follicular hyperkeratosis. Administration of thallium to pregnant animals results in limb deformities, similar to those seen after thalidomide embryopathy. These findings suggest that thallium may act on keratinocytes, melanocytes, and endothelial cells. We show that thallium exerts pleiotropic effects on proliferation, cell shape and motility of multiple cell types. These findings may help explain the clinical findings of thallotoxicosis.
Reactive Perforating Collagenosis and Acquired Perforating Dermatosis: Presentation of Two Cases
Authors: Kyriaki Aroni , Ephtichia Zouridaki , Anna Liossi , Panagiotis Davaris 
Published: April 2015

AbstractTwo rare cases of patients suffering from diabetes mellitus and skin lesions with histological transepidermal elimination are presented. The clinical and histological findings confirmed the diagnoses of reactive perforating collagenosis and acquired perforating dermatosis. The relationship between the two entities and their pathogenesis are discussed.
Scleroderma Renal Crisis Complicated by Hemolytic Uremic Syndrome in a Case of Elderly Onset Systemic Sclerosis
Authors: Yamanaka Kei‐ichi , Mizutani Hitoshi , Hashimoto Kenji , Nishii Masami , Shimizu Masayuki 
Published: April 2015

AbstractWe report a case of renal crisis in a patient with elderly onset systemic scleroderma (SSc). A sixty‐one‐year‐old woman was diagnosed as having SSc with rapidly advancing generalized skin sclerosis. After experiencing an upper respiratory infection, she suddenly developed renal failure, hemolytic anemia and malignant hypertension. Laboratory examination revealed uremia with a significantly high plasma renin level. Ophthalmologic study revealed Keith‐Wagner's retinopathy Grade IV. Combination therapy including captopril, systemic corticosteroid and prostaglandin E1 venous infusion for the hemolytic uremic syndrome was effective and saved her from the renal crisis. However, her renal function deteriorated and she needs permanent hemodialysis. Rapidly progressive skin sclerosis in SSc, especially in elderly onset cases, suggests a high risk for renal crisis and indicates the need for careful consideration of hypertension and renal function.
Exercise‐Induced Urticaria and Angioedema: Reports of Two Cases
Authors: Kato Taizo , Komatsu Hiromi , Tagami Hachiro 
Published: April 2015

AbstractTwo Japanese patients presented with histories of exercise‐induced urticaria and facial angioedema, respectively. Each patient exercised by climbing steep stairs for 5 to 10 min at 22°C. A 19‐year‐old female student with atopic dermatitis initially developed lesions of cholinergic urticaria, which became confluent on her face, trunk and extremities and were followed by discomfort of her throat. In a 34‐year‐old female patient, the exercise induced angioedema on the right eyelids preceded by sneezing and rhinorrhea. Plasma histamine levels were elevated in the first patient. No changes in serum levels of complement systems were observed after the exercise challenge in either patient.
Lichen Planus Pigmentosus Presenting in Zosteriform Pattern
Authors: Cho Soyun , Whang Kyu‐Kwang 
Published: April 2015

AbstractLichen planus pigmentosus (LPP) has thus far been described as a condition of unknown etiology which clinically differs from the classical lichen planus (LP) by exhibiting dark brown macules and/or papules mostly in exposed areas and flexural folds and a longer clinical course without pruritus or scalp, nail or mucosal involvement. Histopathologically, LPP shows the typical changes seen in LP, but with thinning of epidermis. We report a case of LPP that developed in a unilateral, zosteriform pattern on the left flank of a 49‐year‐old man. This case seems to lie in the middle of the spectrum between classical LP and ashy dermatosis, and, to the best of our knowledge, is the first report of LPP presenting in the zosteriform pattern.
Merkel Cell Carcinoma and Multiple Bowen's Disease: Incidental Association or Possible Relationship to Inorganic Arsenic Exposure?
Authors: Ohnishi Yuko , Murakami Shinji , Ohtsuka Hisashi , Miyauchi Shunji , Shinmori Hideyo , Hashimoto Koji 
Published: April 2015

AbstractAn 81‐year‐old Japanese male was referred to our clinic in 1991 with multiple Bowen's disease. The associated hyperpigmentation of the trunk and extremities and palmo‐plantar keratotic nodules indicated that he had suffered from chronic arsenic poisoning. Interestingly, he was a native of Namikata in Ehime, Japan, where many residents have suffered from multiple Bowen's disease with internal malignancy. Arsenic exposure was strongly suspected. Two years later, Merkel cell carcinoma developed on the dorsum of his right hand, where Bowen's disease lesions were absent. Metastasis of this Merkel cell carcinoma led to his eventual death one year later. To our knowledge, this is the first report of Merkel cell carcinoma associated with multiple Bowen's disease. Chronic arsenic poisoning may be responsible for the association of these two rare skin neoplasms.
Giant Basal Cell Carcinomas: Report of Four Cases and Considerations
Authors: Betti Roberto , Inselvini Elena , Moneghini Laura , Crosti Carlo 
Published: April 2015

AbstractFour cases of giant basal cell carcinoma (BCC) are reported and the problems of giant BCCs are briefly discussed. In particular, we consider the relationship between the size of the tumor and its clinical behaviour. The importance of the site location in tumor development, the histologic subtypes involved, the associated findings, and problems of treatment are also discussed.
Anti‐Oxidative Therapy with Oral Dapsone Improved HCV Antibody Positive Annular Elastolytic Giant Cell Granuloma
Authors: Igawa Ken , Maruyama Ryuji , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 72‐year‐old fisherman who was positive for the HCV antibody developed an annular, erythematous, infiltrated lesions on sun‐exposed areas. The lesions were diagnosed as annular elastolytic giant cell granuloma both clinically and histologically. Topical corticosteroid and cryotherapy with liquid nitrogen for several months failed to improve the lesions. We then started dapsone, a known anti‐oxidant, at 50 mg/day. A month later, the margins of the erythematous lesions faded, and the infiltration gradually decreased. No recurrence has been observed for one year after the start of the therapy. Anti‐oxidative therapy appears to be effective for annular elastolytic giant cell granuloma and could be an alternate therapy for refractory granulomatous disease.
A Case of Pigmented Dermatofibrosarcoma Protuberans (Bednar Tumor)
Authors: Akasaka Toshihide , Ohyama Nobutaka , Kon Saiichi 
Published: April 2015

AbstractThe present paper reports a 67‐year‐old male with pigmented dermatofibrosarcoma protuberans (Bednar tumor) on his right shoulder. The lesion had recurred twice. Clinically, the lesion was a reddish‐brown, exophytic, multilobular, firm nodule with an irregular surface, which measured 6.4 times 4.2 cm. Histologically, the proliferated fibroblasts showed a cartwheel pattern and stained positively with CD34, similar to those of a common dermatofibrosarcoma protuberance. However, many melanin‐bearing cells that were positive for the S‐100 protein were found intermingled among the tumor cells.Based on these findings, we concluded that the clinical manifestations, level of malignancy, and cytological features, as well as the exception of melanin‐bearing dendritic cells associated with pigmented dermatofibrosarcoma protuberans, suggest a common dermatofibrosarcoma protuberans. This supports the hypothesis that pigmented dermatofibrosarcoma protuberans is a pigmented variant of dermatofibrosarcoma protuberans. Thus, this type of tumor is not benign, but is an intermediate malignant tumor.
Apoptosis Is Induced by Anti‐Fas Antibody Alone in Cultured Human Keratinocytes
Authors: Sung Kyung Jeh , Paik Eun Mi , Jang Kyoung Ae , Suh Ho Seok , Choi Jee Ho 
Published: April 2015

AbstractFas is a well‐known cell surface receptor whose main function is the induction of apoptosis in many cell types including human keratinocytes. Several reports indicate that anti‐Fas antibody can induce apoptosis in cultured keratinocytes after interferon gamma (IFNγ) pretreatment.Because IFNγ is synthesized by activated T cells, but not by keratinocytes, these results suggest that Fas may only be effective in apoptosis occurring in T‐cell mediated inflammatory skin diseases. We hypothesized that Fas alone might mediate apoptosis in normal human keratinocytes without any other help and thus play a role in normal epidermal homeostasis. By using Cell Death Detection ELISA, we observed keratinocyte apoptosis 24 hours after anti‐Fas antibody stimulation not only in IFNγ‐pretreated conditions but also in non‐pretreated conditions. Even though the percentage of cultured keratinocytes stained by anti‐Fas antibody increased from 7.8 to 25.8% 24 hours after IFNγ stimulation, the apoptotic rate of the anti‐Fas only group was the same as that of the anti‐Fas plus IFNγ treated group. In both conditions, we have verified apoptotic phenomena in cultured keratinocytes in situ by TUNEL staining. Some apoptotic bodies were phagocytosed by neighboring keratinocytes. Fas‐mediated apoptosis was not inhibited by the protein synthesis inhibitor cycloheximide and was enhanced by inhibitors of several protein kinases, including PKC and staurosporine. These results suggest that Fas‐mediated apoptosis may play a role in both T cell‐mediated skin diseases and normal epidermal homeostasis.
CD36 (OKM5) Antigen Expression on Human Mucosal Epithelia Is Associated with Keratinization Type
Authors: Gomez Renate Schlegel , Pelka Michael , Johannessen Anne C. , Hornstein Otto P. , von den Driesch Peter 
Published: April 2015

AbstractThe glycoprotein CD36 functions as a thrombospondin receptor and is expressed on a variety of cell types, including platelets, monocyte/macrophages, and endothelial cells. In human skin, the presence of CD36 on keratinocytes was initially found in lesional areas of T‐cell mediated inflammatory dermatoses. Controversy still exists on the interpretation of this expression as an inflammatory or differentiation‐associated marker. So far, only limited data are available on CD36 expression in oral epithelia. The present immunohistochemical study was therefore performed to determine the presence of CD36 on keratinocytes of healthy and disease‐affected epithelia of the oral cavity in 80 biopsy specimens. As results, we found an inflammation‐independent strong expression of CD36 in oral epithelia with ortho‐ and parakeratinization, such as the oral side of the gingiva, the hard palate, and the back of the tongue. Non‐keratinized epithelia such as the gingival pocket epithelium, the soft palate, the lip, the buccal mucosa, and the side of the tongue were CD36 negative. We therefore suggest that CD36 expression in keratinocytes from oral epithelia is an epithelial differentiation marker.
Folliculosebaceous Cystic Hamartoma with a Neural Component: An Immunohistochemical Study
Authors: Toyoda Masahiko , Morohashi Masaaki 
Published: April 2015

AbstractWe present a case of follicular cystic hamartoma, a distinctive cutaneous malformation characterized by marked overgrowth of folliculosebaceous units accompanied by appreciable mesenchymal alterations, including fibroplasia, increased vascular components, and numerous adipocytes. A conspicuous feature of our case is an aggregation of thick trespassing nerve bundles in the deep portion of the neoplasm. An immunohistochemical study revealed the nerve bundles were immunoreactive for the general neuronal marker protein gene product 9.5. The nerves, however, stained negatively with antibodies against neuropeptides such as calcitonin gene‐related peptide, substance P, vasoactive intestinal polypeptide, and neuropeptide Y, all of which are known to be contained in normal cutaneous nerves. The presence of these aberrant nerve bundles devoid of the normal expression of neuropeptides supports the concept that folliculosebaceous cystic hamartoma is a true, tumor‐like malformation characterized by abnormal overgrowth of normal components of the skin.
A Case of Paget's Disease of the Vulva Recurring in a Musculocutaneous Flap
Authors: Yoshitatsu Sumiko , Hosokawa Ko , Nishimoto So , Yoshikawa Kunihiko 
Published: April 2015

AbstractA case of Paget's disease of the vulva which recurred in a reconstructed gracilis musculocutaneous flap without invasing adenocarcinoma is presented. The recurrent lesion was seen in the basal layer of the epidermis of the flap without invasion into the dermis. The possibility of an intraepidermal lateral invasion of Paget's cells into the epidermis of the flap is suggested.
Pigmented Epidermal Cyst
Authors: Akasaka Toshihide , Imamura Yuko , Kon Saiichi 
Published: April 2015

AbstractA 58‐year‐old Japanese woman with a pigmented epidermal cyst on the upper arch of the right external ear is described.The blue appearance of the cyst was striking and uncommon in Japanese. Histologically, abundant melanin pigment was observed in the keratinous mass of the cavity, and epithelial cells showed epidermoid keratinization. Increased numbers of melanocytes in the basal layer, large globular cells of melanocytic origin in the spinous layer, and hair‐germ‐like aggregates of basaloid cells and melanocytes were also observed.The blue clinical appearance is probably due to the rich melanin granules in the cyst, keratinous mass, keratinocytes, and hair‐germ‐like structures.
Bilateral Accessory Tragi on the Suprasternal Region
Authors: Kim Seok Woo , Moon Sang Eun , Kim Jeong Aee 
Published: April 2015

AbstractWe report a 25‐year‐old man who had two protruding firm masses on his suprasternal region. These lesions were present at birth without any family history. He had no other subjective symptoms. In a histological specimen, there were numerous unevenly distributed telogen follicles that contained vellus hairs. Beneath a relatively narrow zone of fibrovascular tissue, lobules of fat with a central core of cartilage were seen. The mass was totally excised; during the follow‐up period, there was no evidence of recurrence.The tragus derives from the first branchial arch. The accessory tragus can be found along the entire course of embryonic migration. It is usually located unilaterally in the preauricular region. To our knowledge, bilateral development on the suprasternal region has not been previously reported.
Elastic Fibers in Dermis of Juvenile Elastoma
Authors: Kobayasi Takasi , Bartosik Jacek , Ullman Susanne 
Published: April 2015

AbstractTo explore the ultrastructure of elastic fibers in juvenile elastoma, three patients (two without osteopoikilosis and one under examination of bones and joints) were studied by routine electron microscopy. In addition to normal elastic fibers, all the patients also exhibited alterations in elastic fibers. The altered ultrastructures showed lucent, homogenous matrix without peripheral microfibrils. The homogenous matrix were seen in various extensions from the small protrusions of the normal elastic fibers to the complete replacement of the entire fibers. Collagen fibrils occasionally showed twisted figures. Normal shapes of dermal glycosaminoglycans were increased in number. It seems likely that the lucent, homogenous matrix without peripheral microfibrils are the characteristic changes of elastic fibers in juvenile elastoma. The alteration could be nevoid in nature.
Epidermolysis Bullosa Acquisita Localized to the Face
Authors: Choi Gwang Seong , Lee Eun‐So , Kim Soo‐Chan , Lee Sungnack 
Published: April 2015

AbstractA 39‐year‐old woman had a three‐year history of recurrent bullous eruption localized to her left cheeck. The diagnosis of epidermolysis bullosa acquisita was confirmed by means of direct immunofluorescence and direct immunoelectron microscopic studies performed on the perilesional salt‐split skin. Topical corticosteroid treatment reduced pruritus and bullae formation. This case of localized epidermolysis bullosa acquisita on the face is reminiscent of Brunsting‐Perry cicatricial pemphigoid.We also review the previously reported cases of localized epidermolysis bullosa acquisita.
An Unusual Female Melanoma Patient with Late Metastases to Both Skin and Ovaries
Authors: Nakano Junji , Shimizu Takahiro , Hirota Toru , Muto Masahiko 
Published: April 2015

AbstractWe presented an unusual case of cutaneous and bilateral ovarian metastases of malignant melanoma. There was no previously identifiable cutaneous or mucous lesion or teratoid element. Past history revealed that the patient had undergone removal of a blackish, elevated, irregular shaped tumor from the right arm eleven years previously. This lesion was considered to be the primary melanoma; therefore, it was thought to be very unusual as metastasis occurred in both the skin and ovaries after an eleven year disease‐free interval.
A Nevocellular Nevus Consisting mostly of Nevic Corpuscles
Authors: Tomita Kouichi , Furukawa Fukumi , Tokura Yoshiki 
Published: April 2015

AbstractA scalp tumor from a 24‐year‐old male presenting unusual histological finding is described. The tumor was mostly composed of corpuscles resembling Meissner tactile bodies and contained almost no other components.Immunohistochemical studies revealed the tumor cells to be positive for S‐100 protein and neuron‐specific enolase, so we considered the tumor to be an unusual nevocellular nevus mostly comprised of nevic corpuscles.
Pruritic Skin Diseases in the Elderly
Authors: Thaipisuttikul Yupin 
Published: April 2015

AbstractA total of 149 elderly men and women with pruritic skin problems were selected for study at the dermatological clinic in the Department of Medicine, Rajavithi General Hospital, Bangkok, Thailand, from 26 November 1996 to 10 January 1997. There were 62 men (41.6%) and 87 women (58.4%). The average age was seventy years. Among these elderly patients, pruritic skin disease was the most common problem, found in about 41%. Xerosis (senile pruritus) was the most common problem at 38.9%. Other pruritic skin diseases found were inflammatory eczema (22.8%), lichen simplex chronicus (12.1%), skin infections (11.4%), psoriasis vulgaris (6.7%), urticaria (4.7%), drug rash (2%), insect bite (0.7%), and anogenital pruritus (0.7%). Xerosis usually occurred with increased bathing frequency and use of strong soaps and detergents. The causes of inflammatory eczema were seborrheic dermatitis, allergic contact dermatitis, dyshidrosis, and stasis dermatitis. Statistical analysis of xerosis and inflammatory eczema by gender showed no difference, but there was more inflammatory eczema among females.
Ofuji Papuloerythroderma Associated with Follicular Mucinosis in Mycosis Fungoides
Authors: Suh Kee‐Suck , Kim Hyun‐Cheol , Chae Young‐Soo , Kim Sang‐Tae 
Published: April 2015

AbstractOfuji papuloerythroderma is a distinctive clinical entity of unknown etiology, which may occasionally be associated with B cell and T cell lymphoma or visceral malignancy. We report a case of papuloerythroderma associated with follicular mucinosis in mycosis fungoides (MF) that raises the possibility of papuloerythroderma as a form of prelymphomatous skin eruption. This specific papuloerythroderma responded well to the Re‐PUVA treatment, which is a combination of etretinate and PUVA photochemotherapy.
Pemphigus Vegetans Involving the Esophagus
Authors: Ichimiya Makoto , Nakano Junji , Muto Masahiko 
Published: April 2015

AbstractA 44‐year‐old man with pemphigus vegetans had severe odynophagia. He received an endoscopic examination for esophageal involvement. Many white plaque‐like lesions with an erythematous base were seen on the esophageal mucosa. Biopsy from the mucosal epithelial layer showed rounded epidermal cells with large nuclei and numerous inflammatory cells including eosinophils.
Neutrophil Eccrine Hidradenitis in a Patient with AIDS
Authors: Krischer Joachim , Rutschmann Olivier , Roten Sonia Vollenweider , Harms Monica , Saurat Jean‐Hilaire , Pechère Marc 
Published: April 2015

AbstractNeutrophilic eccrine hidradenitis (NEH), first described as a rare, transient, and benign complication of various chemotherapy regimens for acute leukemia, has also been observed in other conditions, including three HIV‐positive patients and even in otherwise healthy individuals (1–3). A similar histological pattern was described after intradermal bleomycin injections into normal human skin (4). We report the first case of NEH in a hemophilic HIV infected patient treated with stavudine, a new reverse transcriptase inhibitor.