bluuebunny/crossref_metadata_2025_split huggingface dataset:
Forced Intergrowth of NaYS2 Phase in Sulfur‐Rich Environments with Fluorescence Remodeling of Upscaled Full‐Spectrum
Authors: Zhao Wenhua , Shen Lifan , Liu Wenhui , Wang Yichao , Chen Baojiu , Pun Edwin Yue Bun , Lin Hai 
Published: July 2024

AbstractOptimization of the host lattice is a novel strategy to achieve efficient up‐conversion luminescence (UCL) with multi‐peak full‐spectrum emission. Herein, lattice optimization is performed in a non‐vacuum sulfur‐rich environment, where the ultra‐low phonon energy NaYS2 heterogeneous phase is forced to intergrow, which overcomes the limitations of the conventional vacuum preparation method and achieves high‐efficient UCL. Remarkably, the lattice sites are preferentially occupied by S2−, which causes lattice distortion and generates layered NaYS2/Y2O2S hybrid crystalline with high inversion asymmetry to reconfigure excitation mechanism and exhibit distinct luminescence centers at the multi‐peak full‐spectrum. Moreover, owing to longer lifetime of excited state energy levels of Er3+ after lattice modification and ordered segregation of Er3+ in the YS6 layer restricting the negative energy exchange process, the luminescence intensity is increased by about six times, and the remodeling of full‐spectrum‐efficient UCLs is realized. This work reports an innovative approach for lattice optimization and a facile preparation of ternary sulfides, which provides a new direction for achieving highly efficient UCLs with promising applications in biomedical imaging, near‐infrared detection, and temperature sensing synergy.
Diabetes Management in Transition: Market Insights and Technological Advancements in CGM and Insulin Delivery
Authors: Yu Tae Sang , Song Soojeong , Yea Junwoo , Jang Kyung‐In 
Published: July 2024

AbstractContinuous Glucose Monitoring (CGM) systems are revolutionizing the real‐time tracking of blood glucose levels, a cornerstone in effective diabetes management and optimal glycemic control. Transitioning from the “intermittent readings” offered by traditional Blood Glucose Monitoring (BGM) methods, CGM delivers an “uninterrupted flow” of glucose data, enabling a “more detailed” strategy for meeting treatment goals. Initially, the “uptake of CGM faced hurdles due to doubts about its precision, but continuous advancements in technology have not only resolved these concerns but also confirms CGM as a dependable and impactful instrument in diabetes management”. Concurrently, advancements in insulin pump technology have improved their portability and ease of use, greatly increasing patient adoption. The market reflects a growing demand for such innovative healthcare solutions, driven by an increased awareness of diabetes management and bolstered by supportive healthcare policies. Future prospects for CGM and insulin pump technologies are incredibly promising, offering the potential for highly personalized care and sophisticated treatment strategies. This paper aims to explore how the synergy between ongoing technological developments and evolving market dynamics is set to redefine the diabetes care paradigm, positioning CGM and insulin pumps as essential elements in enhancing the quality of life for individuals with diabetes.
Design and optimization of spherical agglomeration process based on machine learning strategy
Authors: Zhao Chenyang , Liu Yanbo , Guo Shilin , Feng Shanshan , Ma Yiming , Wu Songgu , Gong Junbo 
Published: July 2024

AbstractSpherical particles stand out as high‐value products with superior macroscopic properties and enhanced downstream processing efficiency. In this study, an integrated digital design strategy, combining artificial neural networks (ANN) and genetic algorithms (GA) has been employed to optimize the spherical agglomeration (SA) process. Initially, a dataset of benzoic acid SA processes was created, which was subsequently employed for training and testing the ANN model. An environmental impact sustainability index (STI) was constructed to assess the environmental effects associated with each operational variable in the SA process. To attain multi‐objective optimization, a GA was employed in combination with the ANN model. In addition, a Score function was formulated to generate Pareto fronts, tailored to meet the specific needs of real scenarios, considering variations in the assigned weights. Furthermore, the model was adapted for aspirin SA process, enhancing predictive abilities with only 20% of original data on operating conditions.
Silica Sulphuric Acid Catalyzed Intra‐Molecular Alkyne Carbonyl Metathesis (ACM): A Rapid Access to 2H‐Chromenes
Authors: Kumar Maurya Rohit , Kumar Vikash , Dey Ashutosh , Kumar Shubham , Khatravath Mahender 
Published: July 2024

AbstractA highly efficient, convenient and ecofriendly approach to access highly functionalized 2H‐chromenes via intramolecular aldehyde alkyne metathesis reaction was established starting from readily accessible alkyne‐tethered 2‐((3‐phenylprop‐2‐yn‐1‐yl) oxy)benzaldehydes and catalyzed by silica sulfuric acid (SiO2‐OSO3H, SSA) coupled with microwave irradiation. This reaction was well tolerated for various substituents including different functional groups and furnished the desired highly functionalized 2H‐chromene derivatives in good to excellent yields in a very short time. A systematic study of the conventional heating approach and microwave irradiation was performed to demonstrate the advantages of the microwave‐assisted condition in terms of high yield and shorter reaction time.
Spontaneous Molecular Bromine Production in Sea‐Salt Aerosols
Authors: Cao Yiqun , Wang Zhuo , Liu Jiarong , Ma Qingxin , Li Shuying , Liu Jun , Li Hao , Zhang Peng , Chen Tianzeng , Wang Yonghong , Chu Biwu , Zhang Xiuhui , Saiz‐Lopez Alfonso , Francisco Joseph S. , He Hong 
Published: July 2024

AbstractBromine chemistry is responsible for the catalytic ozone destruction in the atmosphere. The heterogeneous reactions of sea‐salt aerosols are the main abiotic sources of reactive bromine in the atmosphere. Here, we present a novel mechanism for the activation of bromide ions (Br−) by O2 and H2O in the absence of additional oxidants. The laboratory and theoretical calculation results demonstrated that under dark conditions, Br−, O2 and H3O+ could spontaneously generate Br and HO2 radicals through a proton–electron transfer process at the air–water interface and in the liquid phase. Our results also showed that light and acidity could significantly promote the activation of Br− and the production of Br2. The estimated gaseous Br2 production rate was up to 1.55×1010 molecules cm−2 ⋅ s−1 under light and acidic conditions; these results showed a significant contribution to the atmospheric reactive bromine budget. The reactive oxygen species (ROS) generated during Br− activation could promote the multiphase oxidation of SO2 to produce sulfuric acid, while the increase in acidity had a positive feedback effect on Br− activation. Our findings highlight the crucial role of the proton‐electron transfer process in Br2 production; here, H3O+ facilitates the activation of Br− by O2, serves as a significant source of atmospheric reactive bromine and exerts a profound impact on the atmospheric oxidation capacity.
Maneuverability and Processability of Molecular Crystals
Authors: Lan Linfeng , Zhang Hongyu 
Published: July 2024

AbstractCrystal adaptronics, a burgeoning field at the intersection of materials science and engineering, focuses on harnessing the unique properties of organic molecular crystals to achieve unprecedented levels of maneuverability and processability in various applications. Increasingly, ordered stacks of crystalline materials are being endowed with fascinating mechanical compliance changes in response to external environments. Understanding how these crystals can be manipulated and tailored for specific functions has become paramount in the pursuit of advanced materials with customizable properties. Simultaneously, the processability of organic molecular crystals plays a pivotal role in shaping their utility in real‐world applications. From growth methodologies to fabrication techniques, the ability to precisely machine these crystals opens new avenues for engineering materials with enhanced functionality. These processing methods enhance the versatility of organic crystals, allowing their integration into various devices and technologies, and further expanding the potential applications. This review aims to provide a concise overview of the current landscape in the study of dynamic organic molecular crystals, with an emphasis on the interconnected themes of operability and processability.
Four‐Membered Ring‐Embedded Cycloarene Enabling Anti‐Aromaticity and Ultra‐Narrowband Emission
Authors: Zhang Rong , Xiong Zuping , An Dongyue , Zhu Jiangyu , Gu Yuanhe , Zhang Haoke , Zhou Gang , Liu Yunqi , Lu Xuefeng 
Published: July 2024

AbstractThe synthesis of fully fused π‐conjugated cycloarenes embedded with nonbenzenoid aromatics is challenging. In this work, the first example of four‐membered ring‐embedded cycloarene (MF2) was designed and synthesized in single‐crystal form by macrocyclization and ring fusion strategies. For comparison, single bond‐linked chiral macrocycle MS2 without two fused four‐membered rings and its linear‐shaped polycyclic benzenoid monomer L1 were also synthesized. The pronounced anti‐aromaticity of four‐membered rings significantly adjusts the electronic structures and photophysical properties of cycloarene, resulting in an enhancement of the photoluminescence quantum yield (PLQY) from 10.66 % and 10.74 % for L1 and MS2, respectively, to 54.05 % for MF2, which is the highest PLQY among the reported cycloarenes. Notably, owing to the embedded anti‐aromatic four‐membered rings that reduce structural displacements, MF2 exhibits an ultra‐narrowband emission with a single‐digit full‐width at half‐maximum (FWHM) of only 7 nm (0.038 eV), which sets a new record among all reported organic narrowband luminescent molecules, and represents the first example of ultra‐narrowband emission in conventional polycyclic aromatic hydrocarbons (PAHs) devoid of heteroatoms.
Metal–Organic Framework‐Induced Rh Monocoodination on Diphosphine Ligand Enables Catalytic Hydroformylation of Aliphatic Olefins at Room Temperature and Pressure
Authors: Zheng Zehao , Sun Meng , Zhao Xiangxiang , Zhang Wenqiang , Jiang Hong , Liu Yan , Cui Yong 
Published: July 2024

AbstractPersistent challenges in hydroformylation of olefins include controlling regioselectivity, particularly for short aliphatic olefins and conducting reactions under ambient conditions. We report here the synthesis of monophosphine–Rh complexes on a typical chelated diphosphine ligand mediated by a Zr‐MOF through isolating a pair of phosphorus atoms. We demonstrate that single‐crystal X‐ray diffraction can elucidate the structural transformation of the Rh catalyst during olefin hydroformylation, providing valuable information on active site reconstruction during catalysis. The Rh‐MOF catalyst demonstrates excellent catalytic and recyclable performance in the hydroformylation of short aliphatic olefins with linear to branched ratios of up to 99 : 1. Due to the framework‘s capacity to adsorb and concentrate gases, the catalytic reactions occur under room temperature and pressure, eliminating the need for the high temperature and pressures typically required in homogeneous systems. This study show that Zr–MOF can be a unique platform for synthesizing unusual catalytic species that cannot exist in solutions for meaningful chemical transformations and elucidate valuable structural information pertaining to metal‐based catalysis.
Right trace wrong place: a normal capnography trace despite the tip of the tracheal tube existing outside the airway
Authors: Karmakar A. , Khan M. J. , Shallik N. A. H. , Moustafa A. H. M. N. , Toble Y. M. R. A. , Strandvik G. F. 
Published: July 2024

SummaryHead and neck trauma can result in difficult airway management. A 25‐year‐old male required emergency tracheal intubation on arrival to the emergency department following a motorbike accident. Despite the presence of a normal capnography a computed tomography scan demonstrated a tracheal opening, an extra‐tracheal position of the distal end of the tracheal tube, and extensive subcutaneous emphysema. The tube was re‐directed into the trachea and the tracheal injury was surgically repaired. This case highlights that the presence of a normal capnograph does not necessarily mean that the distal end of the tracheal tube resides within the airway.
The detailed moisture transport structure in extreme precipitation on the Tibetan Plateau caused by storm over the Bay of Bengal
Authors: An Pengchao , Li Ying , Fan Xiaoting , Ye Wei 
Published: July 2024

AbstractThe storms over the Bay of Bengal (BoB) often combine with the weather systems such as the South Branch Trough (SBT) and the West Pacific Subtropical High (WPSH) to transport plenty of moisture inducing extreme precipitation on the Tibetan Plateau (TP). Determining the fine moisture structures of storms helps understand mechanism of this kind of extreme precipitation. An extreme precipitation occurred on the TP influenced by storm Rashmi (2008). A Lagrangian approach is scrutinized the forward and backward moisture transport trajectories of Rashmi and the TP, respectively. The moisture source of this extreme precipitation is relatively clear, which comes from the collaborative influence of Rashmi with the southwest jet generated by the SBT and the WPSH. Utilizing a three‐dimensional K‐means clustering method devised in this study, the Rashmi's forward trajectories are classified into three categories, the particles ascending with the northward movement of Rashmi (45%), consistently below 1 km (37.5%), and rapidly ascending into the southwest jet stream (17.5%). Notably, 97.5%, 1.2%, and 91% of these categories impact the TP, respectively. The moisture transport structure of storm is verified by backward tracking of moisture over the TP. In addition, the three‐dimensional moisture trajectories classification method is recommended when trajectories suffer rapid altitude changes.
Interplay of teacher feedback, parental involvement and peer support on homework engagement of students
Authors: Bas Gokhan , Xu Jianzhong 
Published: July 2024

AbstractThe purpose of the present research was to examine the interplay between teacher feedback, parental involvement and peer support and on homework engagement of students. The research adopted correlation research model, and the participants of the research were students (n = 450) in the central region of Turkey. In the research, ‘Teacher Feedback in Homework Scale’, ‘Parental Involvement in Homework Scale’, ‘Peer Support in Homework Scale’ and ‘Homework Engagement Scale’ were used as data collection instruments. For the analyses, Pearson product–moment correlation and hierarchical multiple regression analyses were performed. The results showed that all research variables have a positive significant correlation with each other. Also, the analysis indicated that teacher feedback, parental involvement and peer support predicted homework engagement of students significantly.
Sample Size Calculation for an Individual Stepped‐Wedge Randomized Trial
Authors: Allemang‐Trivalle Aude , Maruani Annabel , Giraudeau Bruno 
Published: July 2024

ABSTRACTIn the individual stepped‐wedge randomized trial (ISW‐RT), subjects are allocated to sequences, each sequence being defined by a control period followed by an experimental period. The total follow‐up time is the same for all sequences, but the duration of the control and experimental periods varies among sequences. To our knowledge, there is no validated sample size calculation formula for ISW‐RTs unlike stepped‐wedge cluster randomized trials (SW‐CRTs). The objective of this study was to adapt the formula used for SW‐CRTs to the case of individual randomization and to validate this adaptation using a Monte Carlo simulation study. The proposed sample size calculation formula for an ISW‐RT design yielded satisfactory empirical power for most scenarios except scenarios with operating characteristic values near the boundary (i.e., smallest possible number of periods, very high or very low autocorrelation coefficient). Overall, the results provide useful insights into the sample size calculation for ISW‐RTs.
A Shared‐Frailty Spatial Scan Statistic Model for Time‐to‐Event Data
Authors: Frévent Camille , Ahmed Mohamed‐Salem , Dabo‐Niang Sophie , Genin Michaël 
Published: July 2024

ABSTRACTSpatial scan statistics are well‐known methods widely used to detect spatial clusters of events. Furthermore, several spatial scan statistics models have been applied to the spatial analysis of time‐to‐event data. However, these models do not take account of potential correlations between the observations of individuals within the same spatial unit or potential spatial dependence between spatial units. To overcome this problem, we have developed a scan statistic based on a Cox model with shared frailty and that takes account of the spatial dependence between spatial units. In simulation studies, we found that (i) conventional models of spatial scan statistics for time‐to‐event data fail to maintain the type I error in the presence of a correlation between the observations of individuals within the same spatial unit and (ii) our model performed well in the presence of such correlation and spatial dependence. We have applied our method to epidemiological data and the detection of spatial clusters of mortality in patients with end‐stage renal disease in northern France.
Unveiling the potential: Extracellular vesicles from plant cell suspension cultures as a promising source
Authors: Kırbaş Oğuz Kaan , Sağraç Derya , Çiftçi Özgün Cem , Özdemir Gökçeçiçek , Öztürkoğlu Dilek , Bozkurt Batuhan Turhan , Derman Ümit Cem , Taşkan Ezgi , Taşlı Pakize Neslihan , Özdemir Bahar Soğutmaz , Şahin Fikrettin 
Published: July 2024

AbstractExtracellular vesicles are secreted by all eukaryotic cells and they have an important role in intercellular signaling. Plant extracellular vesicles (PEVs) are a novel area of research that has gained attention due to their potential implications in biomolecule transport and therapeutic applications. PEVs are lipid bilayer‐enclosed structures that contain a diverse cargo of biomolecules such as proteins and lipids. Moreover, it is known that PEVs have a noticeable therapeutic potential for various conditions such as inflammation and oxidative stress. However, there are critical problems such as removing the endosomes and plant‐derived biomolecules that decrease the standardization and therapeutic efficacy of PEVs. In our study, the aim was to characterize plant cell suspension‐derived extracellular vesicles (PCSEVs) obtained from two different plant cell suspension cultures: Stevia rebaudiana and Vaccaria hispanica. These vesicles were isolated using ultrafiltration and characterized with nanoparticle tracking analysis (NTA) and atomic force microscopy (AFM). The molecular composition of PCSEVs was profiled and the cellular uptake assay was performed. Our results demonstrated that PCSEVs have a spherical shape, less than 200 nm. In the fatty acid analysis, the primary components in PCSEVs were palmitic acid, linoleic acid, and cis‐vaccenic acid. The protein content of Stevia rebaudiana‐derived EVs (SDEVs) was largely associated with proteins involved in extracellular structures and functions. Conversely, Vaccaria hispanica‐derived EVs (HDEVs) displayed a higher presence of cytosolic proteins. These findings contribute to the understanding of PCSEVs and open up potential avenues in extracellular vesicle research, pointing to promising prospects for future innovations in various fields.
Eye movements and emotions: Efficacy of novel eye‐movement protocol Tholáge
Authors: Martin Gina C. , Chrones Deanna , Fritsch Corey 
Published: July 2024

AbstractBackgroundEye‐movement protocols are considered empirical, evidence‐based treatments for mental disorders, and there is ample research around their efficacy. However, little research as to why these approaches are effective exists. In this study, an emerging approach, titled Tholáge neuropsychotherapy (called RELEASE at the time of the study), is explained and tested through an exploratory mixed method experiment.AimsA new theory on the efficacy of eye‐movement treatments is also presented, exploring existing research and contending that specific emotions are associated with specific eye movements. If proven, it may be possible to use eye movements to access specific emotions, for therapeutic outcomes.MethodsIn this experiment, there were 14 participants (n = 14) who experienced Tholáge as a treatment for depression. Two one‐way ANOVAs were conducted and found to be statistically significant and have a large effect size. Qualitative responses were shared from participants, and themes were highlighted.ResultsThe ANOVAs and qualitative responses demonstrated that Tholáge was effective with emotional regulation, and participants showed improvement on measures of affect and depression (the Positive and Negative Affect Schedule and Beck Depression Inventory).DiscussionThese results show that there is potential for this new eye‐movement treatment in reducing symptoms of depression.ConclusionThese findings can help practitioners in treatment of depression and potentially other diagnoses as well. There needs to be more research studies conducted on the efficacy of this treatment protocol.
Percutaneous coronary intervention for unprotected left main distal bifurcation lesions in elderly people
Authors: Watanabe Yusuke , Naganuma Toru , Chieffo Alaide , Montorfano Matteo , Colombo Antonio 
Published: July 2024

AbstractBackgroundIn the elderly people with unprotected left main distal bifurcation lesions (ULMD), percutaneous coronary intervention (PCI) is often selected as first choice treatment strategy because of perioperative high risk of coronary artery bypass graft surgery due to their large number of comorbidities. Also, some recent papers reported that geriatric nutritional risk index (GNRI) is also strongly associated with clinical outcomes after interventional procedures in elderly patients.ObjectivesWe assessed clinical outcomes after PCI for ULMD and the impact of GNRI in elderly patients.MethodsWe identified 669 non dialysis patients treated with current generation drug‐eluting stent for ULMD from MITO registry. We divided the patients to the following 2 groups; elderly group (n = 240, age ≥75) and young group (n = 429, age <75). Additionally, we could calculate GNRI and divided elderly group into 2 group based on the median value of the GNRI. The primary endpoint was all‐cause mortality.ResultsAll‐cause mortality was significantly higher in elderly group [adjusted hazard ratio (HR) 2.37; 95% confidence interval (CI), 1.40–4.02; p = 0.001]. All‐cause mortality was significantly higher in low GNRI elderly group compared to other 2 groups (Adjusted HR of elderly with low GNRI: 3.56, 95%CI (1.77–7.14), p < 0.001). Cardiovascular mortality was comparable between two groups. TLR rate was significantly lower in elderly group (adjusted HR 0.57; 95% CI, 0.34–0.97; p = 0.035).ConclusionsThe elderly had higher all‐cause mortality after PCI for ULMD compared to young people. Especially, the elderly with low GNRI were extremely associated with poorer outcomes.