bluuebunny/crossref_metadata_2025_split huggingface dataset:
A multicenter, prospective, non‐interventional real‐world study to assess the effectiveness of mecapegfilgrastim in preventing neutropenia in patients with gastrointestinal cancer
Authors: Mao Chenyu , He Ye , Xu Nong , Yan Haijiao , Zhang Ningling , Cheng Gang , Jiang Hua , Chen Minbin , Chen Yong , Wang Xiaoguang , Gu Yulan , Shen Peng , Zhang Guifang , Yan Jun , Yang Zhe , Ding Lifang , Han Zhengxiang , Wang Zhanggui , Zhang Junqi , Zheng Weie , Wang Jufeng , Qin Shukui 
Published: August 2024

AbstractBackgroundMecapegfilgrastim, a long‐acting granulocyte‐colony stimulating factor has been approved for reducing the incidence of infection, particularly febrile neutropenia (FN), in China.ObjectiveWe conducted a multicenter prospective observational study to examine the safety and effectiveness of mecapegfilgrastim in preventing neutropenia in gastrointestinal patients receiving the chemotherapy, including S‐1/capecitabine‐based regimens or the fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFOXIRI)/fluorouracil, leucovorin, and oxaliplatin (FOLFOX)/fluorouracil, leucovorin, oxaliplatin, and irinotecan (FOLFIRINOX) regimens.MethodFive hundred and sixty‐one gastrointestinal patients from 40 sites across China, between May 2019 and November 2021, were included. The administration of mecapegfilgrastim was prescribed at the discretion of local physicians.ResultsThe most common adverse drug reactions (ADRs) of any grade for all patients was increased white blood cells (2.9%). Grade 3/4 ADRs were observed for anemia (0.2%), decreased white blood cells (0.2%), and decreased neutrophil count (0.2%). Among the 116 patients who received S‐1/capecitabine‐based chemotherapy throughout all cycles, ADRs of any grade included anemia (1.7%), myalgia (0.9%), and increased alanine aminotransferase (0.9%). No grade 3/4 ADRs were observed. In 414 cycles of patients who underwent S‐1/capecitabine‐based regimens, only one (0.2%) cycle experienced grade 4 neutropenia. In the FOLFIRINOX, FOLFOXIRI, and FOLFOX chemotherapy regimens, grade 4 neutropenia occurred in one (2.7%) of 37 cycles, four (4.7%) of 85 cycles, and two (1.2%) of 167 cycles, respectively.ConclusionIn a real‐world setting, mecapegfilgrastim has proven effective in preventing severe neutropenia in gastrointestinal patients following chemotherapy. This includes commonly used moderate or high‐risk FN regimens or regimens containing S1/capecitabine, all of which have demonstrated favorable efficacy and safety profiles.
Evaluation of the scrotal thermal environment and the testicular sizes in prepubertal hemiscrotal agenesis without cryptorchidism
Authors: Nishio Hidenori , Mizuno Kentaro , Matsumoto Daisuke , Kamisawa Hideyuki , Kurokawa Satoshi , Nakane Akihiro , Iwatsuki Shoichiro , Maruyama Tetsuji , Yasui Takahiro , Hayashi Yutaro 
Published: August 2024

IntroductionHemiscrotal agenesis is a rare scrotal developmental disorder. Orchiopexy on the opposite side of the scrotum with rugae or scrotoplasty combined with orchiopexy is usually performed as a surgical treatment for hemiscrotal agenesis with cryptorchidism. Till date, there are only eight published case studies of hemiscrotal agenesis.Case presentationA 6‐year‐old boy, who had been previously treated for infantile hemangiomas, was referred by a pediatrician to our hospital for the follow‐up of hemiscrotal agenesis without cryptorchidism. Thermography demonstrated that the temperature of the right scrotal skin with no rugae was higher than that of the left scrotal skin with rugae. The patient's parent declined scrotoplasty because the hemiscrotal agenesis was to be followed up without scrotoplasty and scrotal ultrasonography revealed no abnormal findings in both testes.ConclusionHigh‐temperature environment may not impair the testicular growth in prepubertal hemiscrotal agenesis without cryptorchidism.
QGIS‐based support tools to simplify the complex design challenges of subsurface drainage systems
Authors: Falasy Anamelechi , Cooke Richard 
Published: August 2024

AbstractWe developed a comprehensive set of tools to simplify the design and layout of subsurface drainage systems. These tools, which utilize publicly available LiDAR (light detection and ranging) datasets, may also be used for other applications. The tool streamline operations include harmonizing geographic information system (GIS) layers into a single State Plane or Universal Transverse Mercator Coordinate System, clipping and thinning LiDAR data within a defined boundary, generating drainage networks with contour lines and laylines for surface flow visualization, identifying depressions and creating gridlines with user‐specified angles and spacings. To showcase their use, an illustrative example using a diverse dataset from the University of Illinois’ South Farm is provided. These user‐friendly tools, optimized for compatibility with all versions of QGIS3 (quantum geographic information system 3), are freely accessible for download or installation from the official QGIS plugin repository. A user manual with step‐by‐step instructions is available online on the Illinois Drainage Guide website.
Associations between stress, perfectionism, and imposter phenomenon among dental hygiene students
Authors: Alderton Deborah K. , Boyd Linda D. , Adams Jaymi‐Lyn , Vineyard Jared 
Published: August 2024

AbstractPurpose/objectiveImposter phenomenon (IP) depicts the feeling of being a fraud. Stress and perfection are associated with IP, impairing professional and academic performance and negatively impacting mental health. The purpose of this study was to explore the prevalence of IP and perfectionism in dental hygiene students and the relationship with stress.MethodsThis study used cross‐sectional survey research with a nonprobability sampling of dental hygiene students (n = 258). The study used three validated instruments: the Imposter Profile (IPP30) with six subscales, the Frost Multidimensional Perfectionism Scale Brief with two subscales, and the Perceived Stress Scale (PSS10). Descriptive, correlation, and linear regression were used for analysis.ResultsThe completion rate was 74.8% (n = 193). Linear regression analysis found the competence doubt (CD) subscale of the Imposter‐Profile and perfectionistic striving (PS) were the only statistically significant predictors of stress (F = 10.01, p < .001, R2 = .16). CD (b = 0.36, p < 0.001) was twice as strong as PS (b = 0.15, p < 0.05) in predicting stress in dental hygiene students.ConclusionIn this sample of dental hygiene students, the doubt about competence aspect of imposter phenomenon increased stress more than the striving for perfectionism. Faculty may minimize stress and support students by identifying the feelings associated with imposter phenomenon and highlighting student achievements to build confidence and feelings of self‐efficacy.
Strategic tillage of no‐till decreased surface and subsurface losses of dissolved phosphorus
Authors: Uusitalo Risto , Lemola Riitta , Šuštar Mira , Kurkilahti Mika , Kaseva Janne , Turtola Eila 
Published: August 2024

AbstractEnrichment of soluble P on the surface layer of long‐term no‐till (NT) soils, and consequent increase in dissolved P losses, is a concern for which occasional plowing has been suggested as a remedy. We measured the effect of such strategic tillage (ST) on surface and subsurface P losses from 0.5‐ha field plots on clay soil for 4 years. Two NT plots had discharged threefold dissolved molybdate‐reactive P (DRP) losses compared to annually plowed soil conventional tillage (CT). ST by plowing to 20‐cm depth was applied on one of the NT plots, whereas the other remained under NT. ST done in July was sown with canola (Brassica napus ssp. oleifera) to establish plant cover before winter. Summed 4‐year DRP loss from ST treatment was 60% lower compared to NT (0.78 vs. 1.96 kg ha−1), accompanied with 11% higher particulate P (PP) loss (4.39 vs. 3.97 kg ha−1). CT plots produced slightly lower DRP losses (0.53–0.76 kg ha−1) than ST, but higher PP losses (6.02–7.96 kg ha−1). Bioavailable P (BAP) losses from ST were lower than from the other treatments if >7% of PP turns bioavailable. After ST, soil P stratification first vanished, but started to develop again when NT was resumed. Occasional tillage of NT soils mitigates DRP losses over several years, and it was at the study site the preferred mitigation option in reducing BAP losses.
Temporal patterns of asymptomatic SARS‐CoV‐2 infection among pediatric population in Japan: A 3‐year analysis
Authors: Kozawa Kei , Higashimoto Yuki , Kawamura Yoshiki , Miura Hiroki , Hattori Fumihiko , Mihara Yuka , Nakai Hidetaka , Nishimura Naoko , Ozaki Takao , Ihira Masaru , Yoshikawa Tetsushi 
Published: August 2024

AbstractTo elucidate the seroprevalence and rate of asymptomatic infection with severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) in Japanese children, serological analysis was performed using serum samples collected from March 2020 to February 2023. A total of 1493 serum samples were collected during the first study period (March 2020 to February 2021). None of the serum samples was positive for SARS‐CoV‐2 antibody. In the second period (March 2021 to February 2022), seven of the 1055 patients (0.7%) experienced SARS‐CoV‐2 infection. The third period (March 2022 to February 2023) was divided into three terms: from March to June 30, 2022; from July to October 2022; and from November 2022 to February 2023. The seroprevalence gradually increased throughout this period, with rates of 6.0%, 18.6%, and 30.4% in the three terms, respectively. Pediatric cases of asymptomatic SARS‐CoV‐2 infection occurred after the surge of Omicron variants. Since none of the SARS‐CoV‐2 antibody‐positive patients had a previous history of coronavirus disease 2019, the seroprevalence rate in this study may represent the rate of asymptomatic infection.
Cover Image
Authors: Zhang Ruyuan , Corstens Meinou , Luo Zisheng , Cao Jiarui , Schroen Karin 
Published: August 2024

The cover image is based on the article Effect of pH on the emulsifying performance of protein‐polysaccharide complexes by Ruyuan Zhang et al., https://doi.org/10.1002/jsfa.13601.image
Surgical parameters influence paediatric knee kinematics and cartilage stresses in anterior cruciate ligament reconstruction: Navigating subject‐specific variability using neuromusculoskeletal‐finite element modelling analysis
Authors: Dastgerdi Ayda Karimi , Esrafilian Amir , Carty Christopher P. , Nasseri Azadeh , Barzan Martina , Korhonen Rami K. , Astori Ivan , Hall Wayne , Saxby David John 
Published: August 2024

AbstractPurposeAnterior cruciate ligament (ACL) rupture is increasingly common in paediatric and adolescent populations, typically requiring surgical ACL reconstruction (ACLR) to restore knee stability. However, ACLR substantially alters knee biomechanics (e.g., motion and tissue mechanics) placing the patient at elevated risk of early‐onset knee osteoarthritis.MethodsThis study employed a linked neuromusculoskeletal (NMSK)‐finite element (FE) model to determine effects of four critical ACLR surgical parameters (graft type, size, location and pre‐tension) on tibial articular cartilage stresses in three paediatric knees of different sizes during walking. Optimal surgical combinations were defined by minimal kinematic and tibial cartilage stress deviations in comparison to a corresponding intact healthy knee, with substantial deviations defined by normalized root mean square error (nRMSE) > 10%.ResultsResults showed unique trends of principal stress deviations across knee sizes with small knee showing least deviation from intact knee, followed by large‐ and medium‐sized knees. The nRMSE values for cartilage stresses displayed notable variability across different knees. Surgical combination yielding the highest nRMSE in comparison to the one with lowest nRMSE resulted in an increase of maximum principal stress on the medial tibial cartilage by 18.0%, 6.0% and 1.2% for small, medium and large knees, respectively. Similarly, there was an increase of maximum principal stress on lateral tibial cartilage by 11.2%, 4.1% and 12.7% for small, medium and large knees, respectively. Knee phenotype and NMSK factors contributed to deviations in knee kinematics and tibial cartilage stresses. Although optimal surgical configurations were found for each knee size, no generalizable trends emerged emphasizing the subject‐specific nature of the knee and neuromuscular system.ConclusionStudy findings underscore subject‐specific complexities in ACLR biomechanics, necessitating personalized surgical planning for effective restoration of native motion and tissue mechanics. Future research should expand investigations to include a broader spectrum of subject‐specific factors to advance personalized surgical planning.Level of EvidenceLevel III.
A Month of Vestibular Migraine: Symptom Characterization Using Ecological Momentary Assessment
Authors: Saroya Jasmeet , Humwell Max , Gardi Adam , Chae Ricky , Wong Daniel , Allen Isabel , Sharon Jeffrey D. 
Published: August 2024

Objective(s)This study investigated the frequency and intensity of vestibular migraine (VM) symptoms using Ecological Momentary Assessment (EMA). This approach was intended to provide insights into the day‐to‐day experiences of individuals with VM, contributing to a more comprehensive understanding of this condition.MethodsParticipants reported symptoms to an automated text system, rating their dizziness over the prior 24 h as none, mild, moderate, or severe. Definitive Dizzy Days (DDDs) were defined as days with moderate or severe dizziness. A student's independent group t‐test was used to compare the number of DDDs between VM and probable VM subjects.ResultsSixty‐six subjects were included, with an average of 29 days of pre‐intervention data (SD = 1.4). The average number of days with no dizziness was 3.5 (SD = 6.5), mild dizziness was 9.1 (SD = 6.7), moderate dizziness was 11 (SD = 6.1), and severe dizziness was 5.4 (SD = 6.3). Out of the 66 patients, 52 were classified as VM and 14 as pVM. The average number of DDDs was not significantly different between VM (17.0, SD = 8.3) and pVM (15.3, SD = 10.0) patients, with a two‐tailed p‐value of 0.44.ConclusionWith EMA, we found that the average subject with VM had some degree of dizziness almost every day, and more than 15 DDDs per month.Level of EvidenceIII Laryngoscope, 2024
Lentils: A Recent Review on Global Trade and Popular Regional Cuisines
Authors: Shaikh Marium , Sunooj Kappat Valiyapeediyekkal , Rahman Md. Hafizur , Navaf Muhammed , Ali Tahira Mohsin 
Published: August 2024

ABSTRACTLentils that are considered powerhouse of healthy calories are traditionally consumed in different regions of the world. With the increasing awareness regarding lentils' health‐related benefits, it is getting popular among people of all ages. The rising demand also necessitated the increase in global lentil production with Canada grabbing the top rank among the global producers. This review discussed lentil's trade‐related statistics, along with in depth details of various popular cuisines, and consumption patterns observed in Asia, Middle East, Africa, the United States, Canada, Europe, and Mediterranean region. Lentils are added as ingredient in soups, rice cuisines, pasta, flat breads, salads, nuggets, and burger patties and thus carry its name throughout the food menus from appetizers and salads to main course meals.
Efficient Reversible Upconversion Luminescence Modulation based on Photochromism of Lanthanides‐Doped BaMgSiO4 Glass Ceramics Toward Optical Storage Application
Authors: Zi Yingzhu , Huang Anjun , Zhao Heping , Bai Xue , Xu Zan , Ullah Asad , Liu Yue , Cun Yangke , Song Zhiguo , Qiu Jianbei , Tatiana Cherkasova , Shen Yang , Yang Zhengwen 
Published: August 2024

AbstractTransparent glass with photochromic and luminescent properties has recently garnered considerable interest in optical storage, while the photochromic transparent glass system is still limited. Herein, it is proposed that combining transparent glass matrix with photochromic nanocrystals is an efficient strategy to develop a broader range of photochromic luminescent glass systems. The Yb3+/Tb3+ co‐doped BaMgSiO4 glass ceramics are successfully prepared by a two‐step melt‐quenching approach followed by a thermal treatment in a reducing atmosphere. The glass ceramics exhibit high transparency and distinct coloration, showing a color change between colorless and pink by alternating irradiation between 365 nm ultraviolet light and 473 nm laser. The formation of color centers in the BaMgSiO4 nanoparticles drives the coloration of such glass ceramics. Based on their photochromic and photobleaching behavior, the efficient reversible upconversion luminescence modulation can be implemented with the maximum luminescence modulation rate of 79.83%. The excellent reproducibility and anti‐fatigue of such upconversion luminescence modulation demonstrate the promising application of Yb3+/Tb3+ co‐doped BaMgSiO4 glass ceramics as an optical storage medium.
The effect of tempering time and cooling environment on the corrosion behavior of AA5083‐H111 alloy
Authors: Karagöz İ. , Buğdaycı M. , Öncel L. 
Published: August 2024

AbstractThe tempering process can increase the mechanical properties of the material, such as hardness and impact strength, as well as enhance the corrosion resistance. Therefore, the selection of appropriate tempering time and cooling environment is crucial. This study aims to investigate changes in properties such as hardness, tensile strength, corrosion resistance, and microstructure of AA5083‐H111 alloy after a brief tempering process (30 minutes, 45 minutes and 60 minutes) at 320 °C, followed by cooling in air and water environments. The study found that tempering time and cooling environment significantly affect the mechanical properties and corrosion rate. The results show that samples labeled as S30 and S60 have the highest hardness and impact strength, but the best corrosion resistance is achieved in the S60 sample. This study demonstrates that even after a limited‐term tempering process, the mechanical properties and corrosion resistance of AA5083‐H111 alloy can be improved. This information is crucial data for use in the production and application of alloys. The findings of this study could have important implications for the production and application of AA5083‐H111 alloy in industries such as aerospace, automotive, and marine engineering.
Sound absorption characteristics of 3‐dimensional printed biodegradable structure backed with luffa fiber
Authors: Tyagi R. , Jha N. K. , Tripathi A. , Ranjan N. , Srivastava A. K. , Kumar S. , Kumar R. 
Published: August 2024

AbstractIn this work, an investigation has been carried out on the sound absorption properties of the microperforated composites prepared by filling natural luffa fiber and synthetic luffa fiber. These composite structures are created by 3‐dimensional printing of polylactic acid, which exhibits excellent biodegradability. After preparing the structure, the micro‐perforation is done at the top of the composite with the help of a heated cylindrical drill. During the printing process, the infill density (printing parameter) and type of luffa fiber (natural and synthetic) have been varied to find out its effect on acoustic properties. Finally, a comparative study is carried out among natural luffa fiber and without using natural luffa fiber. The results showed excellent sound absorption of luffa filled structure compared to an unfilled structure. Out of three different infilled densities, the density of 5 % revealed a maximum amount of absorption, suggesting the potential applications of these structures in the field of sound absorption.
Velocity of cerebrospinal fluid in the aqueduct measured by phase‐contrast MRI in rat
Authors: Ding Guangliang , Li Lian , Chopp Michael , Zhang Li , Li Qingjiang , Luo Hao , Wei Min , Zhang Jing , Boyd Edward , Zhang Zhenggang , Jiang Quan 
Published: August 2024

AbstractCerebrospinal fluid (CSF) circulation plays a key role in cerebral waste clearance via the glymphatic system. Although CSF flow velocity is an essential component of CSF dynamics, it has not been sufficiently characterized, and particularly, in studies of the glymphatic system in rat. To investigate the relationship between the flow velocity of CSF in the brain aqueduct and the glymphatic waste clearance rate, using phase‐contrast MRI we performed the first measurements of CSF velocity in rats. Phase‐contrast MRI was performed using a 7 T system to map mean velocity of CSF flow in the aqueduct in rat brain. The effects of age (3 months old versus 18 months old), gender, strain (Wistar, RNU, Dark Agouti), anesthetic agents (isoflurane versus dexmedetomidine), and neurodegenerative disorder (Alzheimer’ disease in Fischer TgF344‐AD rats, males and females) on CSF velocity were investigated in eight independent groups of rats (12 rats per group). Our results demonstrated that quantitative velocities of CSF flow in the aqueduct averaged 5.16 ± 0.86 mm/s in healthy young adult male Wistar rats. CSF flow velocity in the aqueduct was not altered by rat gender, strain, and the employed anesthetic agents in all rats, also age in the female rats. However, aged (18 months) Wistar male rats exhibited significantly reduced the CSF flow velocity in the aqueduct (4.31 ± 1.08 mm/s). In addition, Alzheimer's disease further reduced the CSF flow velocity in the aqueduct of male and female rats.
Enhancing Health Literacy: Evaluating the Readability of Patient Handouts Revised by ChatGPT's Large Language Model
Authors: Swisher Austin R. , Wu Arthur W. , Liu Gene C. , Lee Matthew K. , Carle Taylor R. , Tang Dennis M. 
Published: August 2024

AbstractObjectiveTo use an artificial intelligence (AI)‐powered large language model (LLM) to improve readability of patient handouts.Study DesignReview of online material modified by AI.SettingAcademic center.MethodsFive handout materials obtained from the American Rhinologic Society (ARS) and the American Academy of Facial Plastic and Reconstructive Surgery websites were assessed using validated readability metrics. The handouts were inputted into OpenAI's ChatGPT‐4 after prompting: “Rewrite the following at a 6th‐grade reading level.” The understandability and actionability of both native and LLM‐revised versions were evaluated using the Patient Education Materials Assessment Tool (PEMAT). Results were compared using Wilcoxon rank‐sum tests.ResultsThe mean readability scores of the standard (ARS, American Academy of Facial Plastic and Reconstructive Surgery) materials corresponded to “difficult,” with reading categories ranging between high school and university grade levels. Conversely, the LLM‐revised handouts had an average seventh‐grade reading level. LLM‐revised handouts had better readability in nearly all metrics tested: Flesch‐Kincaid Reading Ease (70.8 vs 43.9; P < .05), Gunning Fog Score (10.2 vs 14.42; P < .05), Simple Measure of Gobbledygook (9.9 vs 13.1; P < .05), Coleman‐Liau (8.8 vs 12.6; P < .05), and Automated Readability Index (8.2 vs 10.7; P = .06). PEMAT scores were significantly higher in the LLM‐revised handouts for understandability (91 vs 74%; P < .05) with similar actionability (42 vs 34%; P = .15) when compared to the standard materials.ConclusionPatient‐facing handouts can be augmented by ChatGPT with simple prompting to tailor information with improved readability. This study demonstrates the utility of LLMs to aid in rewriting patient handouts and may serve as a tool to help optimize education materials.Level of EvidenceLevel VI.