bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving delivery capacity of soy 7S protein via high pressure homogenization: in the case of vitamin D3
Authors: Chen Zhengsong , Zhong Wenjing , Xia Jie , Zhu Jianhua 
Published: February 2025

Abstract
In this work, high pressure homogenization treated soy 7S protein (HPH–7S) was employed as carrier to load and delivery VD3. The encapsulation efficiency (EE) (97.88 %) and bio-accessibility (85.69 %) of VD3 was markedly improved by HPH-7S as compared with that of untreated 7S protein (92.63 %, 73.36 %), while the particle size (80.1 nm) was prominently smaller than that encapsulated by untreated 7S protein (243.3 nm). The photochemical and thermal stability of VD3 in VD3@HPH-7S nanoparticles (VD3@HPH-7S-NPs) was superior to that of VD3 protected by 7S protein. The enhancement of delivery capacity of HPH-7S may be due to the change in protein structure. i.e. the peptide chains of the proteins unfolded during homogenization treatment, exposing more hydrophobic groups and rearranging the tertiary structure, which was verified by Fourier transform infrared, endogenous fluorescence spectrum and surface hydrophobicity.
The adoption of industry 4.0 in the automotive industry: integration of collaborative robot systems in the injection moulding of deformable linear objects
Authors: Alves Filipe , Santos Adriano A. , da Silva António Ferreira , Pereira Filipe , Felgueiras Carlos , Silva Paulo , Machado José 
Published: February 2025

Abstract
The integration of robotic systems plays a significant role in situations where increasing productivity by reducing delivery times is a major challenge for many companies, especially those whose suppliers are negotiating shorter and shorter delivery times. This study describes a process analysis of the integration of a collaborative system into a flexible component injection system for the automotive industry. The article follows a case study research and analysis methodology, so during its development, different phases of the process were addressed, which involved defining, analysing and improving the approach, with an emphasis on the critical aspects that are key to improving the production process. The results showed how a careful study can be useful for improving production processes on a production line. These results are interesting because they made it possible to identify the most economical combination that resulted in an increase in production and quality with a reduced investment. Like all productivity improvement analyses, this can be extrapolated to any other production process, especially if collaborative systems are integrated.
Clinical and laboratory characteristics of propionic acidemia in a Turkish cohort
Authors: Akar Halil Tuna , Kahraman Ayça Burcu , Yıldız Yılmaz , Baran Berat , Çıkı Kısmet , Coşkun Turgay , Yücel Yılmaz Didem , Köksal Özgül Rıza , Hakan Aykan Hayrettin , Dursun Ali , Sivri Serap , Tokatlı Ayşegül 
Published: February 2025

Abstract

Objectives
Propionic acidemia (PA) is an autosomal recessive multisystem disorder caused by the deficiency of propionyl-CoA carboxylase, encoded by PCCA and PCCB genes. This retrospective study presents the clinical and laboratory characteristics of PA patients followed up in our center.

Methods
Included in the study were 50 patients diagnosed in a single center with propionic acidemia between 1984 and 2020, whose electronic and written hospital records regarding demographic, clinical, and laboratory features, along with diagnostic and therapeutic approaches, were reviewed retrospectively.

Results
This cohort had a median age at diagnosis of 18 days and 91.1 % (n=41) were born at term. Consanguinity was notably prevalent (91.1 %), and a family history of PA was reported in 14 % of cases. No significant relationships were observed between clinical and laboratory parameters and mortality. Laboratory findings at the time of diagnosis revealed significant metabolic abnormalities, including low levels of free carnitine, elevated C3 propionyl carnitine, and varied amino acid imbalances. Twenty-three patients exhibited developmental delay and/or intellectual disability. Brain magnetic resonance imaging unveiled white matter involvement and ventricular dilatation in 9/25 patients. Furthermore, dilated cardiomyopathy (26 %) was noted in patients who had cardiac assessments. Among the study cohort, 27 patients survived, 23 patients died during follow-up. No significant relationships were observed between clinical and laboratory parameters and mortality.

Conclusions
Despite improvements in the understanding of the pathophysiology and advances in diagnostic and treatment approaches, propionic acidemia and its long-term complications can still lead to severe consequences. This comprehensive evaluation offers valuable insights into the multifaceted nature of PA.
DNA ligase IV deficiency identified in a patient with hypergonadotropic hypogonadism: a case report
Authors: Yasar Deniz , Sezer Abdullah , Aytekin Caner , Karacan Küçükali Gülin , Özkaya Dönmez Beyhan , Araslı Yılmaz Aslıhan , Okur İclal , Sarıkaya Özdemir Behiye , Kurnaz Erdal , Keskin Melikşah , Savaş Erdeve Şenay 
Published: February 2025

Abstract

Objectives
DNA ligase IV (LIG4) deficiency is a rare autosomal recessive disorder associated with impaired DNA damage-response mechanisms. LIG4 deficiency exhibits a broad clinical spectrum, including microcephaly, facial abnormalities, sensitivity to ionizing radiation, ranging from severe combined immunodeficiency to normal immune function, progressive bone marrow failure, and predisposition to malignancy.

Case Presentation
We report an 18-year-old girl of consanguineous Turkish parents, first evaluated at 13 years old for growth retardation and short stature. She was born preterm at 32 weeks with dysmorphic facial features, lissencephaly, intellectual disability, and without immunodeficiency. Although diagnosed with growth hormone deficiency, she did not receive appropriate hormone therapy due to special circumstances. At the age of 15, she presented with primary amenorrhea. Further evaluation revealed hypergonadotropic hypogonadism due to gonadal failure. Genetic analysis revealed a homozygous c.2440C>T (p.Arg814Ter) mutation in the LIG4 gene. Following genetic counseling, her parents opted for prenatal diagnosis in a subsequent pregnancy, resulting in the birth of another child with the same condition.

Conclusions
LIG4 syndrome should be considered in the differential diagnosis of cases with growth retardation, microcephaly, and gonadal failure. In the literature, there are limited cases reported with gonadal failure in LIG4 syndrome. Here, we emphasize this aspect to highlight its significance.
Influence of excess weight on metabolic risk factors in Argentinian preschool children
Authors: Malpeli Agustina , Stallings Virginia , Sala Marisa , Fasano María Victoria , Varea Ana , Disalvo Liliana , Matamoros Natalia , Tournier Andrea , Gonzalez Horacio F 
Published: February 2025

Abstract

Objectives
Evaluate the differences in metabolic risk factors in preschool children with normal weight (NWG) or with some degree of excess weight (OWG).

Methods
Body mass index (BMI), umbilical waist circumference (WC), mid-upper arm circumference (MUAC) and total body fat (TBF) in children aged 1–5.9 years. The following metabolic risk factors were measured: blood pressure, fasting glycaemia, fasting serum insulin, HOMA IR Index, total cholesterol (TC), LDL cholesterol (LDL-C) HDL cholesterol (HDL-C) and triacylglycerol (TG).

Results
In population evaluated (n:689) MUAC, WC, TBF, HOMA IR were higher in OWG compared to NWG and significantly higher in OWG girls compared to boys (two ways ANOVA). Positive associations were found between diastolic blood pressure, insulin and HOMA IR and WC, MUAC, TBF, BMI z score in the adjusted and unadjusted model.

Conclusions
MUAC may emerge as an indicator with predictive power for metabolic risk and would be very useful to measure in many setting. There is a need for in-depth research into sex difference.
Is oxytocin related to psychiatric symptoms in adolescents with obesity?
Authors: Özyurt Gonca , Çatlı Gönül , Acar Sezer , Cingöz Gülten , Özsoylu Dua , Küme Tuncay , Kızıldağ Sefa , Dündar Bumin Nuri , Öztürk Yusuf , Karagöz Tanıgör Ezgi , Tufan Ali Evren , Abaci Ayhan 
Published: February 2025

Abstract

Objectives
We aimed to investigate the relation of oxytocin receptor (OXTR) gene variants (rs53576 and rs2254298) and serum oxytocin (OXT) levels with psychiatric symptoms in healthy adolescents and adolescents with obesity.

Methods
A total of 250 adolescents with obesity and 250 healthy adolescents were included in this study. Attachment properties, anxiety, and depression were evaluated with self-reports while diagnoses were ascertained with KIDDIE-SADS-PL Turkish version. Serum OXT level was studied with the ELISA method, and OXTR gene variants were studied by quantitative polymerase chain reaction (rs53576) and restriction fragment length polymorphism (RFLP) (rs2254298) methods.

Results
Serum OXT level was significantly lower in adolescents with obesity than in healthy controls. Self-reported symptoms of anxiety and depression were significantly elevated, especially in female adolescents with obesity, whereas parent/peer attachment was significantly lower. The rs53576 G/G genotype was found to be significantly more prevalent among obese youth. About 29.2 % of obese youth were diagnosed with psychopathology, especially anxiety and depression. OXT levels and receptor polymorphisms were not related to self-reported symptoms, attachment, and presence of psychopathology.

Conclusions
Further studies should evaluate the roles of other constructs (e.g., early adversity, parenting, social supports, coping, temperament, etc.) and discern the roles of parent–child synchrony in elucidating relationships between OXT, pediatric obesity, and psychopathology.
Karyotype of the lesser gymnure Hylomys maxi and comparison with its Vietnamese congeners (Mammalia: Eulipotyphla: Erinaceidae)
Authors: Yong Hoi-Sen , Song Sze-Looi 
Published: February 2025

Abstract
The male karyotype of Hylomys maxi has a diploid number (2n) of 46 chromosomes, with a medium-sized submetacentric X and a small acrocentric Y sex chromosomes. It has two chromosomes less than that of the Vietnamese taxa Hylomys peguensis microtinus and Hylomys macarong with 2n = 48, and differs particularly in the morphology of the second largest autosome – metacentric in H. maxi and submetacentric in the Vietnamese taxa. The karyotypes support the molecular findings that H. maxi and H. peguensis microtinus are not conspecific as members of H. suillus.
Enhanced photoluminescence of strongly coupled single molecule-plasmonic nanocavity: analysis of spectral modifications using nonlocal response theory
Authors: Tomoshige Yoshitsugu , Tamura Mamoru , Yokoyama Tomohiro , Ishihara Hajime 
Published: February 2025

Abstract
Plasmonic nanocavities with highly localized fields in their nanogaps significantly enhance light–matter interactions at the nanoscale, surpassing the diffraction limit. Strong coupling between a plasmonic nanocavity and a molecule forms hybrid upper and lower branch states, resulting in Rabi splitting (RS) in optical spectra. However, scattering and absorption spectra often fail to unambiguously distinguish whether the double peaks arise from energy transparency or RS. In contrast, photoluminescence (PL) clearly reveals the quantum state of a molecule coupled with a plasmon by filtering out background fields. This paper presents a theoretical framework based on nonlocal response theory to calculate the PL of a single molecule coupled with arbitrary metallic nanostructures. Our theory provides an analytical approach to design the spatial arrangement of metallic nanostructures and molecular orbitals and to calculate the PL in strongly coupled systems, addressing limitations in previous studies. Using this framework, we investigated a coupled system comprising a gold nanoplate dimer and a planar porphyrin tape. By modifying porphyrin units to modulate coupling strength, we explored the molecular quantum state coupled with the nanocavity through PL analysis. We elucidated the spectral features of absorption, excitation, and PL in weak and strong coupling regimes and evaluated the dependence of coupling strength on the molecular position and orientation within the nanogap. Our results demonstrate that the quantum state of a molecule in an optically forbidden transition can be excited by the highly localized field in the nanogap. This work advances the fundamental understanding of light–matter interactions at the nanoscale and provides a foundation for the development of future nanophotonic devices.
Tunable meta-device for large depth of field quantitative phase imaging
Authors: Cheng Jialuo , Geng Zihan , Zhou Yin , Luo Zhendong , Liu Xiaoyuan , Xiang Yinuo , Zhou Junxiao , Chen Mu Ku 
Published: February 2025

Abstract
In traditional optical imaging, image sensors only record intensity information, and phase information of transparent samples such as cells and semiconductor materials is hard to obtain. Quantitative phase imaging techniques are crucial for obtaining detailed phase information, but current methods often require complex interferometric setups or mechanical adjustments, limiting their practical applicability. Here, we proposed a novel meta-device integrating a PB phase-based meta-lens, a refractive lens, and an electronically tunable lens with a polarization camera to capture multiple defocused images simultaneously for the transport of intensity equation-based phase retrieval algorithm. By leveraging the distinct focus lengths for left-circularly polarized and right-circularly polarized light, the meta-device eliminates the need for multiple shots and mechanical movements. Our approach enables rapid, precise, quantitative phase imaging at different depths. The experiment shows the accuracy of our methods is 98.47 % and with a 2.52 mm depth range of the objects that can be retrieved, making it highly suitable for dynamic and depth-varying samples, such as cells in solution.
Nanophotonic device design based on large language models: multilayer and metasurface examples
Authors: Kim Myungjoon , Park Hyeonjin , Shin Jonghwa 
Published: February 2025

Abstract
Large language models (LLMs) have gained significant prominence in language processing, demonstrating remarkable performance across a wide range of tasks. Recently, LLMs have been explored in various scientific fields beyond language-based tasks. However, their application in the design of nanophotonic devices remains less explored. Here, we investigate the capabilities of LLMs to address nanophotonic design problems without requiring domain-specific expertise of the user. Our findings show that an LLM with in-context learning enables nonexpert users to calculate optical responses of multilayer films via numerical simulations. Through conversational interaction and feedback between the LLM and the user, an optimal design of the multilayer films can be also produced for the user-provided target optical properties. Furthermore, we fine-tune the LLM using text-based representations of the structure and properties of optical metasurfaces. We demonstrate that the fine-tuned LLM can generate metasurface designs with target properties by reversing the input and output text. This research highlights the potential of LLMs to expedite the nanophotonic design process and to make it more accessible to a wider audience.
Solid phase speciation and mobility of thorium in soil samples from a case study in Sri Lanka
Authors: Ratnayake Sanduni , Lützenkirchen Johannes , Schild Dieter , Finck Nicolas , Eiche Elisabeth , Gil-Díaz Teba , Weerasooriya Rohan , Geckeis Horst 
Published: February 2025

Abstract
Sri Lanka has high background radiation due to naturally occurring radionuclides like U-238, Th-232, and K-40 containing minerals. This study investigates the radiological characteristics of soil samples from the Matale District in central Sri Lanka, focusing on thorium (Th) and its potential mobility/bioavailability. Spectrometric data indicate that Th contributes most significantly to the elevated background radiation levels in this area. Thorium, present at approximately 0.2 wt.% in the bulk soil, was analyzed across various mineral phases, including oxides, silicates, and phosphates, using multiple extraction and characterization techniques. Light rare earth elements (REEs) were also examined due to their natural association with Th-bearing minerals. This study provides, for the first time, relevant information on Th minerals in central Sri Lankan soil, addressing a critical research gap in radiological assessments of inland soils in the country. Findings provide insights into radiation exposure risks and the environmental behavior of radionuclides, serving as an important starting point for future studies on radioactive risk assessment in central Sri Lanka. The results contribute to the understanding of soil properties and emphasize the importance of further comprehensive studies to fully assess health risks and develop potential environmental safety measures.
Emergency Medicine Assistants in the Field of Toxicology, Comparison of ChatGPT-3.5 and GEMINI Artificial Intelligence Systems
Authors: Bedel Hatice Aslı , Bedel Cihan , Selvi Fatih , Zortuk Ökkeş , Karanci Yusuf 
Published: February 2025

Objective: Artificial intelligence models human thinking and problem-solving abilities, allowing computers to make autonomous decisions. There is a lack of studies demonstrating the clinical utility of GPT and Gemin in the field of toxicology, which means their level of competence is not well understood. This study compares the responses given by GPT-3.5 and Gemin to those provided by emergency medicine residents.Methods: This prospective study was focused on toxicology and utilized the widely recognized educational resource ‘Tintinalli Emergency Medicine: A Comprehensive Study Guide’ for the field of Emergency Medicine. A set of twenty questions, each with five options, was devised to test knowledge of toxicological data as defined in the book. These questions were then used to train ChatGPT GPT-3.5 (Generative Pre-trained Transformer 3.5) by OpenAI and Gemini by Google AI in the clinic. The resulting answers were then meticulously analyzed.Results: 28 physicians, 35.7% of whom were women, were included in our study. A comparison was made between the physician and AI scores. While a significant difference was found in the comparison (F=2.368 and p<0.001), no significant difference was found between the two groups in the post-hoc Tukey test. GPT-3.5 mean score is 9.9±0.71, Gemini mean score is 11.30±1.17 and, physicians’ mean score is 9.82±3.70 (Figure 1).Conclusions: It is clear that GPT-3.5 and Gemini respond similarly to topics in toxicology, just as resident physicians do.
A Multicomponent Educational and Rehabilitation Approach in Optimizing Outcomes During the Poststroke Subacute Phase
Authors: Glinac Alma , Sinanović Osman 
Published: February 2025

Background: Poststroke patients often experience cognitive impairments, motor weakness, and difficulties in daily activities. A multicomponent educational-rehabilitation approach offers a holistic treatment by integrating cognitive and motor training with relaxation, adaptive skills training, and motivational components. Despite its potential benefits, there is limited evidence supporting its effectiveness during the subacute stroke phase. This study evaluates the impact of this approach on cognitive functions, upper extremity motor skills, and daily activity independence during the subacute phase.Materials and Methods: In a prospective, randomized clinical trial, 40 patients participated in a 20-session multicomponent educational-rehabilitation program consisting of 45-minute sessions, five days a week. This program combined cognitive and motor training with additional components such as relaxation and patient education. The control group (N=30) received standard physical therapy, including electrotherapy and speech therapy as needed. Assessments were conducted at admission, after the final session for the experimental group, and one month later for the control group.Results: The experimental group demonstrated significantly greater improvements in cognitive abilities, upper extremity functionality, and daily activity independence compared to the control group (p < 0.001).Conclusion: The multicomponent educational-rehabilitation approach significantly enhances cognitive function, motor skills, and daily activity independence during the subacute phase of stroke recovery. These findings suggest that this approach offers superior recovery outcomes compared to standard care, warranting further investigation into its long-term effects.
Obecności. Prolegomena do tematu o zagranicznej recepcji literatury polskiej
Authors: Cudak Romuald 
Published: February 2025

Artykuł podejmuje problematykę obecności literatury polskiej w świecie. Wskazuje, że światowość literatury polskiej można rozumieć jako jej udział w światowym systemie literatury, jako obecność literatury światowej w literaturze polskiej oraz jako jej tworzenie poza granicami kraju. Zagadnienia te podejmują badania nad szeroko rozumianą recepcją, badania z zakresu komparatystyki i translatologii oraz historycznoliterackie. W artykule wskazuje się, iż w badaniach pomocne są rozważania teoretyczne m.in. nad procesem i aparatem literatury (R. Escarpit), dotyczące literatury jako polisystemu (I. Even-Zohar) i światowej republiki literatury (P. Casanova) oraz figurami literatury światowej.
W drugiej części opisane są przykłady recepcji literatury polskiej w zagranicznych kulturach i polisystemach literackich reprezentatywne dla recepcji hegemona i obecności w systemach peryferyjnych, jak również formy obecności dzieł i pisarzy polskich w świecie (poezja współczesna, twórczość O. Tokarczuk).
Mythopoetic Fantasy: In Search of Harmony with the World. Metatheoretical Considerations that use the Example of Tolkien’s Arda
Authors: Jastrzębski Marek 
Published: February 2025

In the presented research, the author reflects on the prevalent opinion among literary critics regarding the escapism of mythopoetic fantasy. According to the article’s thesis, considering the specificity of the contemporary understanding of reality against which the alleged escapism of fantasy is directed, as well as the character of the narrative worlds of mythopoetic fantasy, the primary aim is not escapism but rather a pursuit of harmony with the world. Investigating the validity of this claim, the issues conditioning our contemporary understanding of the world are analysed. This is followed by a presentation of the literary universe of fantasy (primarily in the mythopoeic subgenre) understood as a form of rebellion: a rebellion not against reality itself, but against the modern perception of the world. Embracing Eliade’s concept of homo religiosus, the author concludes that mythopoeic fantasy seeks to enable contemporary humans to sacralise their perception of the reality as a means of retuning to the natural way of perceiving the universe inherent to the religious nature of humanity. The article concludes that the purpose of mythopoeic fantasy is to seek harmony with the world rather than escaping from it.