bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterizing electrodermal response habituation: A latent class approach with application to psychopathology
Authors: Isen Joshua D. , Iacono William G. , Malone Stephen M. 
Published: July 2013

AbstractResponse habituation is a fundamental form of nonassociative learning, yet there are substantial individual differences in its electrodermal manifestation. We employed a latent class analysis to identify discrete groups of electrodermal responders to a series of loud tones. We also evaluated whether heterogeneity in responsiveness was associated with lifetime prevalence of externalizing psychopathology and major depression. Participants were community‐recruited men (N = 1,141) who underwent a standard habituation paradigm. A latent class analysis resulted in the identification of four electrodermal populations: rapid habituators, habituators, and two classes that showed weak response habituation, but differed markedly in their amplitude profiles. Relative to rapid habituators, members of slower habituating classes were less likely to receive lifetime diagnoses of antisocial personality disorder and substance dependence. Further research using this analytical strategy could help identify the functional significance of individual differences in habituation.
Warm‐temperate, marine, carbonate sedimentation in an Early Miocene, tide‐influenced, incised valley; Provence, south‐east France
Authors: James Noel P. , Seibel Margaret J. , Dalrymple Robert W. , Besson David , Parize Olivier 
Published: July 2013

AbstractThe Saumane‐Venasque compound palaeovalley succession accumulated in a strongly tide‐influenced embayment or estuary. Warm‐temperate normal marine to brackish conditions led to deposition of extensive cross‐bedded biofragmental calcarenites. Echinoids, bryozoans, coralline algae, barnacles and benthic foraminifera were produced in seagrass meadows, on rocky substrates colonized by macroalgae and within subaqueous dune fields. There are two sequences, S1 and S2, the first of which contains three high‐frequency sequences (S1a, S1b and S1c). Sequence 1 is largely confined to the palaeovalley with its upper part covering interfluves. Each of these has a similar upward succession of deposits that includes: (i) a basal erosional surface that is bored and glauconitized; (ii) a discontinuous lagoonal lime mudstone or wackestone; (iii) a thin conglomerate generated by tidal ravinement; (iv) a transgressive systems tract series of cross‐bedded calcarenites; (v) a maximum flooding interval of argillaceous, muddy quartzose, open‐marine limestones; and (vi) a thin highstand systems tract of fine‐grained calcarenite. Tidal currents during stages S1a, S1b and S1c were accentuated by the constricted valley topography, whereas basin‐scale factors enhanced tidal currents during the deposition of S2. The upper part of the succession in all but S1c has been removed by later erosion. There is an overall upward temporal change with quartz, barnacles, encrusting corallines and epifaunal echinoids decreasing but bryozoans, articulated corallines and infaunal echinoids increasing. This trend is interpreted to be the result of changing oceanographic conditions as the valley was filled, bathymetric relief was reduced, rocky substrates were replaced as carbonate factories by seagrass meadows and subaqueous dunes, and the setting became progressively less confined and more open marine. These limestones are characteristic of a suite of similar cool‐water calcareous sand bodies in environments with little siliciclastic or fresh water input during times of high‐amplitude sea‐level change wherein complex inboard antecedent topography was flooded by a rising ocean.
Hidden Treasures in Theological Education: The Writing Tutor, the Spiritual Director, and Practices of Academic and Spiritual Mentoring
Authors: Yaghjian Lucretia B. 
Published: July 2013

AbstractMentoring is an important but often overlooked resource in theological education and students' academic and spiritual formation. This essay profiles the mentoring practices and postures of the writing tutor and the spiritual director as exemplars of academic and spiritual mentoring. An extended probe of this analogy affirms the integration of academic and spiritual formation as a core value in theological education; identifies mentoring in theological education as a hidden treasure fostering this integration and warranting attention as a theological practice; and re‐envisions the theological practice of mentoring under the traditional rubric of the “care of souls,” embracing the relational, educational, formational, spiritual, and rhetorical dimensions of this practice.
On the arithmetic fundamental lemma in the minuscule case
Authors: Rapoport Michael , Terstiege Ulrich , Zhang Wei 
Published: July 2013

AbstractThe arithmetic fundamental lemma conjecture of the third author connects the derivative of an orbital integral on a symmetric space with an intersection number on a formal moduli space of$p$-divisible groups of Picard type. It arises in the relative trace formula approach to the arithmetic Gan–Gross–Prasad conjecture. We prove this conjecture in the minuscule case.
Differential T- and B-Cell Responses to Pertussis in Acellular Vaccine-Primed versus Whole-Cell Vaccine-Primed Children 2 Years after Preschool Acellular Booster Vaccination
Authors: Schure Rose-Minke , Hendrikx Lotte H. , de Rond Lia G. H. , Öztürk Kemal , Sanders Elisabeth A. M. , Berbers Guy A. M. , Buisman Anne-Marie 
Published: July 2013

ABSTRACT
This study investigated long-term cellular and humoral immunity against pertussis after booster vaccination of 4-year-old children who had been vaccinated at 2, 3, 4, and 11 months of age with either whole-cell pertussis (wP) or acellular pertussis (aP) vaccine. Immune responses were evaluated until 2 years after the preschool booster aP vaccination. In a cross-sectional study (registered trial no. ISRCTN65428640), blood samples were taken from wP- and aP-primed children prebooster and 1 month and 2 years postbooster. Pertussis vaccine antigen-specific IgG levels, antibody avidities, and IgG subclasses, as well as T-cell cytokine levels, were measured by fluorescent bead-based multiplex immunoassays. The numbers of pertussis-specific memory B cells and gamma interferon (IFN-γ)-producing T cells were quantified by enzyme-linked immunosorbent spot assays. Even 2 years after booster vaccination, memory B cells were still present and higher levels of pertussis-specific antibodies than prebooster were found in aP-primed children and, to a lesser degree, also in wP-primed children. The antibodies consisted mainly of the IgG1 subclass but also showed an increased IgG4 portion, primarily in the aP-primed children. The antibody avidity indices for pertussis toxin and pertactin in aP-primed children were already high prebooster and remained stable at 2 years, whereas those in wP-primed children increased. All measured prebooster T-cell responses in aP-primed children were already high and remained at similar levels or even decreased during the 2 years after booster vaccination, whereas those in wP-primed children increased. Since the Dutch wP vaccine has been replaced by aP vaccines, the induction of B-cell and T-cell memory immune responses has been enhanced, but antibody levels still wane after five aP vaccinations. Based on these long-term immune responses, the Dutch pertussis vaccination schedule can be optimized, and we discuss here several options.
Demonstrated Efficacy of a Pilot Heterologous Whole-Spore Vaccine against Microsporidial Gill Disease in Rainbow Trout
Authors: Harkness J. E. , Guselle N. J. , Speare D. J. 
Published: July 2013

ABSTRACT

Intraperitoneal vaccines using whole viable spores of the microsporidian
Glugea anomala
or
Glugea hertwigi
reduced the numbers of branchial xenomas by 80% and 91%, respectively, after a standard experimental infection of juvenile rainbow trout with the microsporidian
Loma salmonae
. Similar significant results were obtained when killed-spore preparations were used.
Glycoproteins gB and gH Are Required for Syncytium Formation but Not for Herpesvirus-Induced Nuclear Envelope Breakdown
Authors: Schulz Katharina S. , Klupp Barbara G. , Granzow Harald , Mettenleiter Thomas C. 
Published: July 2013

ABSTRACT
Herpesvirus nucleocapsids are assembled in the nucleus, whereas maturation into infectious virions takes place in the cytosol. Since, due to their size, nucleocapsids cannot pass the nuclear pores, they traverse the nuclear envelope by vesicle-mediated transport. Nucleocapsids bud at the inner nuclear membrane into the perinuclear space, forming primary enveloped particles and are released into the cytosol after fusion of the primary envelope with the outer nuclear membrane. The nuclear egress complex (NEC), consisting of the conserved herpesvirus proteins (p)UL31 and pUL34, is required for this process, whereas the viral glycoproteins gB and gH, which are essential for fusion during penetration, are not. We recently described herpesvirus-induced nuclear envelope breakdown (NEBD) as an alternative egress pathway used in the absence of the NEC. However, the molecular details of this pathway are still unknown. It has been speculated that glycoproteins involved in fusion during entry might play a role in NEBD. By deleting genes encoding glycoproteins gB and gH from the genome of NEBD-inducing pseudorabies viruses, we demonstrate that these glycoproteins are not required for NEBD but are still necessary for syncytium formation, again emphasizing fundamental differences in herpesvirus-induced alterations at the nuclear envelopes and plasma membranes of infected cells.
Myeloblastic Cell Lines Mimic Some but Not All Aspects of Human Cytomegalovirus Experimental Latency Defined in Primary CD34+Cell Populations
Authors: Albright Emily R. , Kalejta Robert F. 
Published: July 2013

ABSTRACTHuman cytomegalovirus (HCMV) is a significant human pathogen that achieves lifelong persistence by establishing latent infections in undifferentiated cells of the myeloid lineage, such as CD34+hematopoietic progenitor cells. When latency is established, viral lytic gene expression is silenced in part by a cellular intrinsic defense consisting of Daxx and histone deacetylases (HDACs) because pp71, the tegument transactivator that travels to the nucleus and inactivates this defense at the start of a lytic infection in differentiated cells, remains in the cytoplasm. Because the currentin vitroandex vivolatency models have physiological and practical limitations, we evaluated two CD34+myeloblastic cell lines, KG-1 and Kasumi-3, for their ability to establish, maintain, and reactivate HCMV experimental latent infections. Tegument protein pp71 was cytoplasmic, and immediate-early (IE) genes were silenced as in primary CD34+cells. However, in contrast to what occurs in primary CD34+cellsex vivoor in NT2 and THP-1in vitromodel systems, viral IE gene expression from the laboratory-adapted AD169 genome was not induced in the presence of HDAC inhibitors in either KG-1 or Kasumi-3 cells. Furthermore, while the clinical strain FIX was able to reactivate from Kasumi-3 cells, AD169 was not, and neither strain reactivated from KG-1 cells. Thus, KG-1 and Kasumi-3 experimental latent infections differ in important parameters from those in primary CD34+cell populations. Aspects of latency illuminated through the use of these myeloblastoid cell lines should not be considered independently but integrated with results obtained in primary cell systems when paradigms for HCMV latency are proposed.
Modelling the impact of specific food policy options on coronary heart disease and stroke deaths in Ireland
Authors: O'Keeffe Celine , Kabir Zubair , O'Flaherty Martin , Walton Janette , Capewell Simon , Perry Ivan J 
Published: July 2013

ObjectiveTo estimate the potential reduction in cardiovascular (CVD) mortality possible by decreasing salt, trans fat and saturated fat consumption, and by increasing fruit and vegetable (F/V) consumption in Irish adults aged 25–84 years for 2010.DesignModelling study using the validated IMPACT Food Policy Model across two scenarios. Sensitivity analysis was undertaken. First, a conservative scenario: reductions in dietary salt by 1 g/day, trans fat by 0.5% of energy intake, saturated fat by 1% energy intake and increasing F/V intake by 1 portion/day. Second, a more substantial but politically feasible scenario: reductions in dietary salt by 3 g/day, trans fat by 1% of energy intake, saturated fat by 3% of energy intake and increasing F/V intake by 3 portions/day.SettingRepublic of Ireland.OutcomesCoronary heart disease (CHD) and stroke deaths prevented.ResultsThe small, conservative changes in food policy could result in approximately 395 fewer cardiovascular deaths per year; approximately 190 (minimum 155, maximum 230) fewer CHD deaths in men, 50 (minimum 40, maximum 60) fewer CHD deaths in women, 95 (minimum 75, maximum 115) fewer stroke deaths in men, and 60 (minimum 45, maximum 70) fewer stroke deaths in women. Approximately 28%, 22%, 23% and 26% of the 395 fewer deaths could be attributable to decreased consumptions in trans fat, saturated fat, dietary salt and to increased F/V consumption, respectively. The 395 fewer deaths represent an overall 10% reduction in CVD mortality. Modelling the more substantial but feasible food policy options, we estimated that CVD mortality could be reduced by up to 1070 deaths/year, representing an overall 26% decline in CVD mortality.ConclusionsA considerable CVD burden is attributable to the excess consumption of saturated fat, trans fat, salt and insufficient fruit and vegetables. There are significant opportunities for Government and industry to reduce CVD mortality through effective, evidence-based food policies.
Geochemistry, palaeoenvironments and timing of Aptian organic-rich beds of the Paja Formation (Curití, Eastern Cordillera, Colombia)
Authors: Gaona-Narvaez Tatiana , Maurrasse Florentin J.-M.R. , Etayo-Serna Fernando 
Published: July 2013

Abstract

At the Curití Quarry, Eastern Cordillera of Colombia, a 23.35 m section includes a 6.3 m interval of organic-rich marlstones, calcareous clay-shales and clay-shales devoid of benthic fossils and bioturbation, at the base of the Paja Formation. It overlies carbonate ramp deposits of the Rosablanca Formation, with the topmost layer containing reworked and phosphatized assemblages of middle Barremian to lowest Aptian ammonites of the genera
Pulchellia
,
Gerhardtia
,
Toxancycloceras
,
Karsteniceras
and
Prodeshayesites
. High-resolution analyses of the section, including total inorganic carbon (TIC, 0.09–50 wt%), total organic carbon (TOC, up to 8.4%) and stable carbon isotope measurements (δ
13
C
org
between −22.05‰ and −20.47‰) allow the determination of the stratigraphic relationship between the organic-rich level within the Paja Formation and Oceanic Anoxic Event-1a (OAE-1a). The range of values and the overall pattern of the δ
13
C
org
curve are comparable with the Lower Aptian interval C7. Thus, the organic-rich shale interval of the Paja Formation at the Curití section, showing characteristics of oxygen-depleted conditions, was deposited after OAE-1a, which is known to occur between isotopic levels C3 and C6.

Supplementary material:

TIC, TOC and Stable Carbon Isotope data at Curiti Section are available at
http://www.geolsoc.org.uk/SUP18634
Unexpected Effect of Proton Pump Inhibitors
Authors: Ghebremariam Yohannes T. , LePendu Paea , Lee Jerry C. , Erlanson Daniel A. , Slaviero Anna , Shah Nigam H. , Leiper James , Cooke John P. 
Published: July 2013

Background—
Proton pump inhibitors (PPIs) are gastric acid–suppressing agents widely prescribed for the treatment of gastroesophageal reflux disease. Recently, several studies in patients with acute coronary syndrome have raised the concern that use of PPIs in these patients may increase their risk of major adverse cardiovascular events. The mechanism of this possible adverse effect is not known. Whether the general population might also be at risk has not been addressed.

Methods and Results—
Plasma asymmetrical dimethylarginine (ADMA) is an endogenous inhibitor of nitric oxide synthase. Elevated plasma ADMA is associated with increased risk for cardiovascular disease, likely because of its attenuation of the vasoprotective effects of endothelial nitric oxide synthase. We find that PPIs elevate plasma ADMA levels and reduce nitric oxide levels and endothelium-dependent vasodilation in a murine model and ex vivo human tissues. PPIs increase ADMA because they bind to and inhibit dimethylarginine dimethylaminohydrolase, the enzyme that degrades ADMA.

Conclusions—
We present a plausible biological mechanism to explain the association of PPIs with increased major adverse cardiovascular events in patients with unstable coronary syndromes. Of concern, this adverse mechanism is also likely to extend to the general population using PPIs. This finding compels additional clinical investigations and pharmacovigilance directed toward understanding the cardiovascular risk associated with the use of the PPIs in the general population.
How is model selection determined in a vocal mimic?: Tests of five hypotheses
Authors: Gammon David E. 
Published: July 2013

Many animal species imitate the sounds of other species, but we know little about why vocal mimics copy some species while failing to copy other species, i.e., ‘model selection’. In this observational study of free-living northern mockingbirds (Mimus polyglottos), I tested five hypotheses of model selection: (1) Proximity hypothesis: preferential imitation of species found in close proximity to the vocal mimic, (2) Aggression hypothesis: preferential imitation of species with which the mimic interacts aggressively, (3) Passive sampling hypothesis: preferential imitation of species heard frequently by the mimic, (4) Acoustic similarity hypothesis: preferential imitation of species whose sounds are acoustically similar to the non-imitative songs of the vocal mimic and (5) Alarm hypothesis: preferential imitation of alarm-associated vocalisations. The data supported only the acoustic similarity hypothesis. Given that this hypothesis has been supported in two additional mimicking lineages, it suggests a potential non-adaptive explanation for the evolution of vocal mimicry. Species that learn vocalisations are already predisposed toward learning sounds with key acoustic characteristics. Whenever natural selection favours a widening of the auditory template that guides model selection, vocal imitation of heterospecifics becomes more likely because of ‘learning mistakes’.
Sudhausia aristotokia n. gen., n. sp. and S. crassa n. gen., n. sp. (Nematoda: Diplogastridae): viviparous new species with precocious gonad development
Authors: Herrmann Matthias , Ragsdale Erik J. , Kanzaki Natsumi , Sommer Ralf J. 
Published: July 2013

Two new species of diplogastrid nematodes,Sudhausia aristotokian. gen., n. sp. andS. crassan. gen., n. sp., were isolated from dung beetles (Coleoptera: Scarabaeidae) in Ghana and South Africa, respectively.Sudhausian. gen. is circumscribed by stomatal morphology, namely the presence of a tube-shaped gymnostom, a pair of conical subventral denticles in the metastegostom, and a disk-like telostegostom bearing minute conical denticles. Other characters distinguishing the new genus are the presence of a bursa in the male and a vulva lined anteriorly and posteriorly by columns of sac-like cells. The two new species, both of which are hermaphroditic, are distinguished from each other by spicule and gubernaculum morphology, male papillae arrangement, bursal shape, vaginal morphology, and phasmid position. A suite of unusual developmental traits that distinguishesSudhausian. spp. includes maturation of the gonad and development of juvenile progeny before moulting to adulthood, a two-fold increase in embryo size during development, and constitutive vivipary. A phylogeny inferred from 11 ribosomal protein-coding genes and a fragment of the small subunit rRNA gene showSudhausian. gen. to be divergent from other sequenced diplogastrid taxa, including those characterised by a tube-like stoma. The two new species represent useful new reference points for the study of feeding-structure evolution in Diplogastridae.
Climate Changes of Atlantic Tropical Cyclone Formation Derived from Twentieth-Century Reanalysis
Authors: Wang Ruifang , Wu Liguang 
Published: July 2013

AbstractWhereas some studies linked the enhanced tropical cyclone (TC) formation in the North Atlantic basin to the ongoing global warming, other studies attributed it to the warm phase of the Atlantic multidecadal oscillation (AMO). Using the National Oceanic and Atmospheric Administration (NOAA) Earth System Research Laboratory (ESRL) Twentieth Century Reanalysis (20CR) dataset, the present study reveals the distinctive spatial patterns associated with the influences of the AMO and global warming on TC formation in the North Atlantic basin.Two leading empirical orthogonal function (EOF) patterns are identified in the climate change of TC formation on time scales longer than interannual. The first pattern is associated with the AMO and its spatial pattern shows the basin-scale enhancement of TC formation during the AMO positive phase. The second pattern is associated with global warming, showing enhanced TC formation in the east tropical Atlantic (5°–20°N, 15°–40°W) and reduced TC formation from the southeast coast of the United States extending southward to the Caribbean Sea. In the warm AMO phase, the basinwide decrease in vertical wind shear and increases in midlevel relative humidity and maximum potential intensity (MPI) favor the basinwide enhancement of TC formation. Global warming suppresses TC formation from the southeast coast of the United States extending southward to the Caribbean Sea through enhancing vertical wind shear and reducing midlevel relative humidity and MPI. The enhanced TC formation in the east tropical Atlantic is due mainly to a local increase in MPI or sea surface temperature (SST), leading to a close relationship between the Atlantic SST and TC activity over the past decades.
Scientific Assessment of the SWIFT Instrument Design
Authors: Rahnama Peyman , Gault William A. , McDade Ian C. , Shepherd Gordon G. 
Published: July 2013

Abstract
The Stratospheric Wind Interferometer for Transport Studies (SWIFT) is a proposed satellite instrument. SWIFT is an imaging field-widened Doppler Michelson interferometer. It observes a thermal IR atmospheric emission line in a limb-viewing geometry in order to measure stratospheric winds and stratospheric ozone concentration profiles with global coverage during both day and night. SWIFT has the capability of improving the knowledge of the dynamics of the stratosphere and global distribution of and global transport of ozone. The target wind and ozone accuracies are 3 m s−1 and 5%–10%, respectively. The instrument is a follow up to the highly successful Canada–France Wind-Imaging Interferometer (WINDII) instrument on NASA's Upper Atmosphere Research Satellite (UARS). To assess the suitability of the method of Doppler imaging Michelson interferometry for the measurement of stratospheric wind and ozone using the SWIFT instrument, a scientific assessment of the instrument performance was undertaken using forward and inverse modeling and error analyses. This paper is aimed at determining the technical and scientific feasibility of the SWIFT instrument and its ability to meet the science requirements. This paper also briefly describes the SWIFT experiment, the data retrieval algorithms, and technical challenges in stratospheric wind measurements. Meeting the wind accuracy requirement imposes tight requirements on instrument thermal stability, filter monitoring, and determination of reference phase calibration. The SWIFT instrument design shows a strong level of dependence on the knowledge of atmospheric N2O concentration. The presence of N2O as an interfering species degrades the SWIFT performance at all altitudes with the largest impact especially for altitudes below 30 km.