bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis, Crystal Structure, and Optical Properties of a New Sodium‐Cadmium Carbonate Na4Cd3(CO3)4(OH)2.
Authors: Chen Jie , Luo Min , Ye Ning 
Published: April 2015

AbstractColorless block‐shaped crystals of the title compound are hydrothermally synthesized from mixtures of CdCl2, Na2CO3, and H2O (autoclave, 220 °C, 5 d, 80% yield).
ChemInform Abstract: GeP and (Ge1‐xSnx)(P1‐yGey) (x ≈ 0.12, y ≈ 0.05): Synthesis, Structure, and Properties of Two‐Dimensional Layered Tetrel Phosphides.
Authors: Lee Kathleen , Synnestvedt Sarah , Bellard Maverick , Kovnir Kirill 
Published: April 2015

AbstractGeP and Sn‐doped GeP are prepared by solid state reactions of the elements in either Bi or Sn metal flux (1223 K, 96 h).
ChemInform Abstract: Enantioselective Allylation of tert‐Butyldimethylsilyl‐Protected Vanillin and Synthesis of a Lignan Derivative Isolated from Machilus wangchiana.
Authors: Cadart Timothee , Koukal Petr , Kotora Martin 
Published: April 2015

AbstractEnantioselective allylation and crotylation of tert‐butyldimethylsilyl protected vanillin proceeds with high asymmetric induction by using different catalytic systems.
ChemInform Abstract: β‐Functionalization of Carboxylic Anhydrides with β‐Alkyl Substituents Through Carbene Organocatalysis.
Authors: Jin Zhichao , Chen Shaojin , Wang Yuhuang , Zheng Pengcheng , Yang Song , Chi Yonggui Robin 
Published: April 2015

AbstractThe first NHC‐catalyzed reaction of aliphatic carboxylic acid anhydrides (I) and (IV) with diones (II) and (V), as well as chalcones (VII), and isatins (IX) is presented to give substituted cyclopentenes (III), (VI), (VIII), and spirocyclic butyrolactones (X).
ChemInform Abstract: Acid Promoted Cyclodehydration of Amino Alcohols with Amide Acetal.
Authors: Hwang Soonho , Park Heemin , Kwon Yongseok , Kim Sanghee 
Published: April 2015

AbstractSeveral types of pyrrolidines and piperidines are successfully prepared in good to high yields from corresponding amino alcohols using N,N‐dimethylacetamide dimethyl acetal as activating agent of the hydroxyl groups.
ChemInform Abstract: Iron Nitrate/TEMPO: A Superior Homogeneous Catalyst for Oxidation of Primary Alcohols to Nitriles in Air.
Authors: Dighe Shashikant U. , Chowdhury Deepan , Batra Sanjay 
Published: April 2015

AbstractA highly practical, one‐step, facile synthesis of aromatic, heteroaromatic, allylic and aliphatic nitriles from primary alcohols catalyzed by ferric nitrate in the presence of TEMPO, aqueous ammonia and air at room temperature is described.
ChemInform Abstract: Copper‐Catalyzed Reductive Cross‐Coupling of Nonactivated Alkyl Tosylates and Mesylates with Alkyl and Aryl Bromides.
Authors: Liu Jing‐Hui , Yang Chu‐Ting , Lu Xiao‐Yu , Zhang Zhen‐Qi , Xu Ling , Cui Mian , Lu Xi , Xiao Bin , Fu Yao , Liu Lei 
Published: April 2015

AbstractThe first Cu‐catalyzed reductive cross‐coupling reaction of nonactivated alkyl tosylates or mesylates with alkyl and aryl bromides is presented.
ChemInform Abstract: Copper(II) Bromide as an Efficient Catalyst for Acetal to Bisarylmethyl Ether Interconversion.
Authors: Mezaache Rofia , Harkat Hassina , Obszynski Julie , Benkouider Abdelhamid , Blanc Aurelien , Weibel Jean‐Marc , Pale Patrick 
Published: April 2015

AbstractThe simple method permits the conversion of 1,3‐dioxolanes and 1,3‐dioxanes into bis(methoxyphenyl)methyl ethers.
ChemInform Abstract: Acid‐ and Isobutylene‐Free Synthesis of t‐Butyl Ethers by in situ Formation of 2‐t‐Butoxy‐1‐methylpyridinium Triflate.
Authors: Salvati Anna E. , Hubley Christian T. , Albiniak Philip A. 
Published: April 2015

AbstractPrimary and secondary alcohols are converted into tert‐butyl ethers using the title reagent generated in situ by alkylation of 2‐tert‐butoxypyridine.
ChemInform Abstract: Cyclopeptoids as Phase‐Transfer Catalysts for the Enantioselective Synthesis of α‐Amino Acids.
Authors: Schettini Rosaria , Nardone Brunello , De Riccardis Francesco , Della Sala Giorgio , Izzo Irene 
Published: April 2015

AbstractNine alternating N‐substituted‐glycine and proline hexacyclopeptoids are employed in the alkylation of N‐(diphenylmethylene)glycine tert‐butyl ester.
ChemInform Abstract: Asymmetric Enamine Catalysis with β‐Ketoesters by Chiral Primary Amine: Divergent Stereocontrol Modes.
Authors: Xu Changming , Zhang Long , Luo Sanzhong 
Published: April 2015

AbstractThis describes different methods for the conversion of α‐substituted β‐ketoesters via asymmetric aminocatalysis.
ChemInform Abstract: Chiral Auxiliary Induced Diastereoselective Synthesis of (R,R)‐N,N′‐Di(tert‐butoxycarbonyl)cyclohex‐4‐ene‐1,2‐diamine.
Authors: Balestri Davide , Grilli Stefano , Romano Ciro , Savoia Diego 
Published: April 2015

AbstractThe synthesis of the title compound (VI) is based on the highly diastereoselective addition of allylzinc bromide to bisimine (I) and ring‐closing metathesis as the key steps.
ChemInform Abstract: Sandmeyer Difluoromethylation of (Hetero‐)Arenediazonium Salts.
Authors: Matheis Christian , Jouvin Kevin , Goossen Lukas J. 
Published: April 2015

AbstractAn in situ generated difluoromethyl‐copper complex reacts with aryldiazonium salts to form difluoromethyl arenes under mild conditions.
ChemInform Abstract: Facile Synthesis of Cyclohexanediones and Dialkylresorcinols — Bioactive Natural Products from Entomopathogenic Bacteria.
Authors: Kronenwerth Max , Dauth Christina , Kaiser Marcel , Pemberton Iain , Bode Helge B. 
Published: April 2015

AbstractThe crucial step in the synthesis of cyclohexanediones (VI) is the formation of six‐membered ring from α,β‐unsaturated ketones (IV) and diethyl malonate, followed by saponification and decarboxylation.
ChemInform Abstract: Convenient Synthesis of α‐Nitrooximes Mediated by OXONE®.
Authors: Chumnanvej Napasawan , Samakkanad Natthapol , Pohmakotr Manat , Reutrakul Vichai , Jaipetch Thaworn , Soorukram Darunee , Kuhakarn Chutima 
Published: April 2015

AbstractAn easy and environmentally benign approach to α‐nitrooximes from styrene derivatives is developed employing a new combination of NaNO2 and Oxone.
ChemInform Abstract: Sequential Multicomponent Synthesis of α‐Ketoimides, from Acyl Chlorides, Isocyanides, and Silver Salts of Carboxylic Acids.
Authors: La Spisa Fabio , Tron Gian Cesare 
Published: April 2015

AbstractThe sequential three component reaction of acyl chlorides, isocyanides, and silver carboxylates affords moderately stable keto‐iminoanhydrides which spontaneously undergo a Mumm rearrangement to produce the target α‐ketoimides (IX) and (XI).
ChemInform Abstract: Tris(pentafluorophenyl)borane Catalyzed Synthesis of Cyanohydrins, Cyanohydrin Trimethylsilyl Ethers and α‐Amino Nitriles.
Authors: Yaragorla Srinivasarao , Sudhakar A. , Kiranmai N. 
Published: April 2015

AbstractSimple and mild reaction conditions, low levels of catalyst loading, high yields and shorter reaction times compared to existing methods are the advantages of this methodology.
ChemInform Abstract: Palladium‐Catalyzed Desulfitative Cross‐Coupling of Arylsulfinates with Arylboronic Acids.
Authors: Cheng Kai , Yu Hai‐Zhu , Zhao Baoli , Hu Sai , Zhang Xian‐Man , Qi Chenze 
Published: April 2015

AbstractThe catalytic reaction is accelerated by addition of a catalytic amount of Cu(II) salts as co‐catalyst.
ChemInform Abstract: Synthesis of (E)‐1,4‐Enediones from α‐Halo Ketones Through a Sodium Sulfinate Mediated Reaction.
Authors: Li Su‐Yi , Wang Xiao‐Bing , Jiang Neng , Kong Ling‐Yi 
Published: April 2015

AbstractThe title coupling reaction involves the formation of a β‐ketosulfone intermediate, which reacts with α‐halo ketones to form symmetrical or unsymmetrical 1,4‐enediones with complete E‐selectivity.
ChemInform Abstract: Palladium‐Catalyzed peri‐Selective Chalcogenation of Naphthylamines with Diaryl Disulfides and Diselenides via C—H Bond Cleavage.
Authors: Iwasaki Masayuki , Kaneshika Wataru , Tsuchiya Yuta , Nakajima Kiyohiko , Nishihara Yasushi 
Published: April 2015

AbstractThe picolinamide moiety acts as directing group for the selective formation of peri‐thiolated and peri‐selenated products.
ChemInform Abstract: Enantioselective Synthesis of Spiroimines by Asymmetric Decarboxylative Alkylation/Isomerization/[3 + 2]‐Cycloaddition Reaction of Azidoalkenes.
Authors: Rambla Matt , Duroure Leslie , Chabaud Laurent , Guillou Catherine 
Published: April 2015

AbstractThe synthesis of optically active spiroimines, one of the pharmacophores of the marine neurotoxin gymnodimine A, is described.
ChemInform Abstract: Catalyst and Solvent‐Free Cyclopropanation of Electron‐Deficient Olefins with Cyclic Diazoamides for the Synthesis of Spiro[cyclopropane‐1,3′‐indolin]‐2′‐one Derivatives.
Authors: Karthik Govindaraju , Rajasekaran Tamilselvan , Sridhar B. , Reddy B.V.Subba 
Published: April 2015

AbstractThe simple method provides the title products in high yield as mixtures of diastereomers.
ChemInform Abstract: A Convenient Method for Synthesis of Polyfunctional Dihydropyrrole Spiro‐Fused Oxindole‐2‐ones via an Organocatalytic Tandem Michael/Cyclization Sequence.
Authors: Liu Xiong‐Wei , Yang Jun , Yang Chao , Han Wen‐Yong , Liu Xiong‐Li , Zhou Ying , Yu Zhang‐Biao , Yuan Wei‐Cheng 
Published: April 2015

AbstractOptimized conditions allow the diastereoselective reaction of 3‐aminooxindoles with α,α‐dicyanoolefins to give the title compounds in high yields.
ChemInform Abstract: Synthesis of Novel Dispiropyrrolothiazoles by Three‐Component 1,3‐Dipolar Cycloaddition and Evaluation of Their Antimycobacterial Activity.
Authors: Haddad Saoussen , Boudriga Sarra , Porzio Francois , Soldera Armand , Askri Moheddine , Sriram Dharmarajan , Yogeeswari Perumal , Knorr Michael , Rousselin Yoann , Kubicki Marek M. 
Published: April 2015

AbstractNovel dispiropyrrolothiazole derivatives (IV) and (VI) are synthesized under mild reaction conditions in a complete regio‐ and stereoselective manner using three‐component 1,3‐dipolar cycloaddition reactions of cyclic diketones (I) or (V) with thiazolanecarboxylic acid (II) and arylidenepyrolidinedione (III) The dispiropyrrolothiazole derivatives (IVf) and (IVg) are found to exhibit significant antimycobacterial activity and emerge as the most promising antitubercular agents.
ChemInform Abstract: Direct Oxidative Coupling of Enamides and 1,3‐Dicarbonyl Compounds: A Facile and Versatile Approach to Dihydrofurans, Furans, Pyrroles, and Dicarbonyl Enamides.
Authors: Li Pan , Zhao Jingjing , Xia Chungu , Li Fuwei 
Published: April 2015

AbstractA facile protocol for the oxidative coupling of 1,3‐dicarbonyl compounds with enamides to give dihydrofurans is developed.
ChemInform Abstract: Catalytic [2 + 2 + 2] Cycloaddition of Benzothiophene Dioxides with α,ω‐Diynes for the Synthesis of Condensed Polycyclic Compounds.
Authors: Tahara Yu‐ki , Gake Manami , Matsubara Riku , Shibata Takanori 
Published: April 2015

AbstractThe new protocol allows the synthesis of a wide variety of condensed polycyclic compounds including the 11‐membered ring product (X) resulting from consecutive reaction of tetraoxide (IX) with 1,7‐diyne (VIII).
ChemInform Abstract: Sequential Ugi Four‐Component Reaction (4‐CR)/C—H Activation Using (Diacetoxyiodo)benzene for the Synthesis of 3‐(Diphenylmethylidene)‐2,3‐dihydro‐1H‐indol‐2‐ones.
Authors: Ghabraie Elmira , Balalaie Saeed 
Published: April 2015

AbstractThe presented procedure offers several advantages such as good yields, high bond‐forming efficiency, selectivity, and short reaction times.
ChemInform Abstract: Exceptionally Mild Palladium(II)‐Catalyzed Dehydrogenative C—H/C—H Arylation of Indolines at the C‐7 Position under Air.
Authors: Jiao Lin‐Yu , Smirnov Polina , Oestreich Martin 
Published: April 2015

AbstractAn operationally simple way for the direct installation of aryl groups at the C‐7 position of indolines is reported.
ChemInform Abstract: Synthesis of Polysubstituted Pyrazoles by a Platinum‐Catalyzed Sigmatropic Rearrangement/Cyclization Cascade.
Authors: Wen Jia‐Jie , Tang Hai‐Tao , Xiong Kai , Ding Zong‐Cang , Zhan Zhuang‐Ping 
Published: April 2015

AbstractThe method tolerates various functional groups, thus offering a convenient access to highly functionalized pyrazoles including medicinally relevant 3‐trifluoromethyl substituted derivatives [cf.
ChemInform Abstract: Three Questionable Cases in the Chemistry of Quinoxalines and Benzodiazepines in the Way of the Syntheses of Benzimidazoles.
Authors: Mamedov Vakhid A. , Murtazina Anna M. , Adgamova Dil'bar I. , Zhukova Nataliya A. , Beschastnova Tat'yana N. , Kharlamov Sergey V. , Rizvanov Il'dar Kh. , Latypov Shamil K. 
Published: April 2015

AbstractThe reaction of (I) with Vilsmeier reagent to give (III), the reaction of (V) with aqueous NaOH to give (VI), and the reaction of (X) with o‐phenylenediamine to give (XI) are studied and earlier reports are revised.
ChemInform Abstract: ′Green′ Synthesis of 1,4‐Disubstituted 5‐Iodo‐1,2,3‐triazoles under Neat Conditions, and an Efficient Approach of Construction of 1,4,5‐Trisubstituted 1,2,3‐Triazoles in One Pot.
Authors: Wang Dong , Chen Si , Chen Baohua 
Published: April 2015

AbstractA novel protocol for the copper‐catalyzed cycloaddition of iodoalkynes and organic azides to give 5‐iodosubstituted triazoles (III) is presented.
ChemInform Abstract: 10‐Camphorsulfonic Acid ((.+‐.)‐CSA) Catalyzed Facile One‐Pot Synthesis of a New Class of 2,5‐Disubstituted 1,3,4‐Oxadiazoles.
Authors: Mule Siva Nagi Reddy , Battula Sailaja Kumari , Velupula Ganapathi , Guda Dinneswara Reddy , Bollikolla Hari Babu 
Published: April 2015

AbstractThe title compounds (III)/(VI) are obtained by CSA‐catalyzed reaction of carboxylic acid hydrazides with different carboxylic acid chlorides.
ChemInform Abstract: A Catalyst‐Free Green Protocol for the Synthesis of Pyranopyrazoles Using Room Temperature Ionic Liquid Choline Chloride‐Urea.
Authors: Swaroop Toreshettahally R. , Sharath Kumar Kothanahally S. , Palanivelu Mariyappan , Chaitanya Somu , Rangappa Kanchugarakoppal S. 
Published: April 2015

Abstract17 Title compounds of type (IV) or (VI) are prepared by a four‐component reaction.
ChemInform Abstract: Catalytic Asymmetric Difunctionalization of Stable Tertiary Enamides with Salicylaldehydes: Highly Efficient, Enantioselective, and Diastereoselective Synthesis of Diverse 4‐Chromanol Derivatives.
Authors: He Ling , Zhao Liang , Wang De‐Xian , Wang Mei‐Xiang 
Published: April 2015

AbstractThe title reaction affords a wide variety of cis‐trans‐configured 4‐chromanols.
ChemInform Abstract: Rapid and Efficient One‐Pot Green Synthesis of 12‐Aryl‐8,9,10,12‐tetrahydrobenzo[a]xanthene‐11‐ones Using Zr‐MCM‐41 Catalyst.
Authors: Olyaei Abolfazl , Alidoust Mona Ghodrat 
Published: April 2015

AbstractA new green method for the efficient synthesis of the title xanthene derivatives via three‐component condensation reactions of naphthols with dimedone and aromatic aldehydes is developed.
ChemInform Abstract: Sodium Chloride: A Proficient Additive for the Synthesis of Pyridine Derivatives in Aqueous Medium.
Authors: Gujar Jitendra B. , Chaudhari Mahendra A. , Kawade Deepak S. , Shingare Murlidhar S. 
Published: April 2015

AbstractThe synthetic strategy toward highly functionalized pyridines succeeds efficiently for aryl aldehydes, but with significantly lower yields if aliphatic aldehydes are involved.
ChemInform Abstract: A New Approach to Pyridines Through the Reactions of Methyl Ketones with 1,2,4‐Triazines.
Authors: Wang Shu‐Wen , Guo Wei‐Si , Wen Li‐Rong , Li Ming 
Published: April 2015

AbstractA new route to prepare pyridine derivatives via an inverse electron demand Diels—Alder/retro‐Diels—Alder reaction of triazines with methyl ketones is reported.
ChemInform Abstract: Sc(OTf)3‐Catalyzed Bicyclization of o‐Alkynylanilines with Aldehydes: Ring‐Fused 1,2‐Dihydroquinolines.
Authors: Zhu Can , Ma Shengming 
Published: April 2015

AbstractThe Sc(OTf)3‐catalyzed tandem aza‐Prins cyclization of o‐alkynylanilines (I) with a variety of aromatic aldehydes gives access to furanoquinolines.
ChemInform Abstract: Ligand‐Controlled Regiodivergent Pathways of Rhodium(III)‐Catalyzed Dihydroisoquinolone Synthesis: Experimental and Computational Studies of Different Cyclopentadienyl Ligands.
Authors: Wodrich Matthew D. , Ye Baihua , Gonthier Jerome F. , Corminboeuf Clemence , Cramer Nicolai 
Published: April 2015

AbstractDepending on the choice of Rh‐catalyst and reaction solvent the directed C‐H functionalization of arylhydroxamates (I) with styrenes can be controlled to yield either 4‐ or 3‐arylated products (III) and (IV) with high regioselectivity.
ChemInform Abstract: Heavier Alkaline Earth Catalyzed Ene‐yne Cyclizations: Atom‐Efficient Access to Tetrahydroisoquinoline Frameworks.
Authors: Reid Stephanie , Barrett Anthony G. M. , Hill Michael S. , Procopiou Panayiotis A. 
Published: April 2015

AbstractIntermolecular alkene hydroamination may be coupled with intramolecular alkyne hydroamination, catalyzed by inexpensive and abundant alkaline earth precatalysts to provide entry to a variety of tetrahydroisoquinoline frameworks.
ChemInform Abstract: Synthesis of Benzo[de]isoquino[1,8‐gh]quinolines and Light‐Induced Electron Transfer in Their Composites with Conductive Polymer Poly(3‐hexylthiophene).
Authors: Baranov Denis S. , Popov Aleksandr G. , Uvarov Mikhail N. , Kulik Leonid V. 
Published: April 2015

AbstractLight‐induced electron transfer from the regioregular poly(3‐hexylthiophene) to the synthesized molecules is detected by an EPR spectroscopy technique.
ChemInform Abstract: A Phosphine‐Catalyzed Novel Asymmetric [3 + 2] Cycloaddition of C,N‐Cyclic Azomethine Imines with δ‐Substituted Allenoates.
Authors: Wang De , Lei Yu , Wei Yin , Shi Min 
Published: April 2015

AbstractThe first example of the highly enantio‐ and diastereoselective 1,3‐dipolar cycloaddition of azomethine imines with δ‐substituted allenic esters is demonstrated using a chiral (S)‐Me‐f‐KetalPhos (FEC) catalyst under optimized conditions.
ChemInform Abstract: Reversed‐Polarity Synthesis of Diaryl Ketones Through Palladium‐Catalyzed Direct Arylation of 2‐Aryl‐1,3‐dithianes.
Authors: Yucel Baris , Walsh Patrick J. 
Published: April 2015

AbstractFenofibrate (IX) is prepared on a 3.1 g scale.
ChemInform Abstract: Synthesis of α‐Aryl‐diazophosphonates via Palladium‐Catalyzed Cross‐Coupling of Aryl Iodides with Diethyl Diazomethylphosphonate.
Authors: Kosobokov Mikhail D. , Titanyuk Igor D. , Beletskaya Irina P. 
Published: April 2015

AbstractIn contrast to aryl iodides, aryl bromides and aryl chlorides are not applicable to the presented cross‐coupling reaction.
ChemInform Abstract: Xylariterpenoids A—D, Four New Sesquiterpenoids from the Xylariaceae fungus.
Authors: Wu Zu‐Yan , Wu Yang , Chen Guo‐Dong , Hu Dan , Li Xiao‐Xia , Sun Xiang , Guo Liang‐Dong , Li Yan , Yao Xin‐Sheng , Gao Hao 
Published: April 2015

AbstractThe compounds (I) and (II), xylariterpenoids A‐D, are screened for their activity against HL‐60, SMMC‐7721, A‐549, MCF‐7, and SW480 human cancer cell lines and they show no significant cytotoxicity.
ChemInform Abstract: Pegaharmalines A (I) and B (II), Two Novel β‐Carboline Alkaloids with Unprecedented Carbon Skeletons from Peganum harmala.
Authors: Wang Kai‐Bo , Yuan Chun‐Mao , Xue Chun‐Mei , Li Da‐Hong , Jing Yong‐Kui , He Hong‐Ping , Hao Xiao‐Jiang , Di Ying‐Tong , Li Zhan‐Lin , Hua Hui‐Ming 
Published: April 2015

AbstractThe title compounds are screened for their activity against five human cancer cell lines and show significant cytotoxicity against HL‐60 cells with IC50 values of 9.4 and 13.6 μM, respectively.
ChemInform Abstract: An Inhibitor of the Adipogenic Differentiation of 3T3‐L1 Cells, Yoshinone A, and Its Analogues, Isolated from the Marine Cyanobacterium Leptolyngbya sp.
Authors: Inuzuka Toshiyasu , Yamamoto Keita , Iwasaki Arihiro , Ohno Osamu , Suenaga Kiyotake , Kawazoe Yoshinori , Uemura Daisuke 
Published: April 2015

AbstractYoshinone A (I) and the diastereomeric yoshinones B1 and B2 (II) are evaluated towards their adipogenic differentiation of 3T3‐L1 cells with (I) showing potential as a novel lead compound for treatment of obesity.
Convergence of lemniscal and local excitatory inputs on large GABAergic tectothalamic neurons
Authors: Ito Tetsufumi , Hioki Hiroyuki , Sohn Jaerin , Okamoto Shinichiro , Kaneko Takeshi , Iino Satoshi , Oliver Douglas L. 
Published: April 2015

ABSTRACTLarge GABAergic (LG) neurons form a distinct cell type in the inferior colliculus (IC), identified by the presence of dense VGLUT2‐containing axosomatic terminals. Although some of the axosomatic terminals originate from local and commissural IC neurons, it has been unclear whether LG neurons also receive axosomatic inputs from the lower auditory brainstem nuclei, i.e., cochlear nuclei (CN), superior olivary complex (SOC), and nuclei of the lateral lemniscus (NLL). In this study we injected recombinant viral tracers that force infected cells to express GFP in a Golgi‐like manner into the lower auditory brainstem nuclei to determine whether these nuclei directly innervate LG cell somata. Labeled axons from CN, SOC, and NLL terminated as excitatory axosomatic endings, identified by colabeling of GFP and VGLUT2, on single LG neurons in the IC. Each excitatory axon made only a few axosomatic contacts on each LG neuron. Inputs to a single LG cell are unlikely to be from a single brainstem nucleus, since lesions of individual nuclei failed to eliminate most VGLUT2‐positive terminals on the LG neurons. The estimated number of inputs on a single LG cell body was almost proportional to the surface area of the cell body. Double injections of different viruses into IC and a brainstem nucleus showed that LG neurons received inputs from both. These results demonstrated that both ascending and intrinsic sources converge on the LG somata to control inhibitory tectothalamic projections. J. Comp. Neurol. 523:2277–2296, 2015. © 2015 Wiley Periodicals, Inc.
Differential modification of cortical and thalamic projections to cat primary auditory cortex following early‐ and late‐onset deafness
Authors: Chabot Nicole , Butler Blake E. , Lomber Stephen G. 
Published: April 2015

ABSTRACTFollowing sensory deprivation, primary somatosensory and visual cortices undergo crossmodal plasticity, which subserves the remaining modalities. However, controversy remains regarding the neuroplastic potential of primary auditory cortex (A1). To examine this, we identified cortical and thalamic projections to A1 in hearing cats and those with early‐ and late‐onset deafness. Following early deafness, inputs from second auditory cortex (A2) are amplified, whereas the number originating in the dorsal zone (DZ) decreases. In addition, inputs from the dorsal medial geniculate nucleus (dMGN) increase, whereas those from the ventral division (vMGN) are reduced. In late‐deaf cats, projections from the anterior auditory field (AAF) are amplified, whereas those from the DZ decrease. Additionally, in a subset of early‐ and late‐deaf cats, area 17 and the lateral posterior nucleus (LP) of the visual thalamus project concurrently to A1. These results demonstrate that patterns of projections to A1 are modified following deafness, with statistically significant changes occurring within the auditory thalamus and some cortical areas. Moreover, we provide anatomical evidence for small‐scale crossmodal changes in projections to A1 that differ between early‐ and late‐onset deaf animals, suggesting that potential crossmodal activation of primary auditory cortex differs depending on the age of deafness onset. J. Comp. Neurol. 523:2297–2320, 2015. © 2015 Wiley Periodicals, Inc.