bluuebunny/crossref_metadata_2025_split huggingface dataset:
Envafolimab Inhibits the Growth of Gastric Cancer Cells with Low PD-L1
Expression through the DDX20/NF-κB/TNF-α Signaling Pathway
Authors: Dong Zhuanxia , Yang Zefeng , Ren Jing , Li Feng , Wang Guangyu , Wang Yusheng 
Published: July 2024

Background:
The mechanism of action of envafolimab (also known as KN035), a programmed death ligand 1 (PD-L1) inhibitor, in gastric adenocarcinoma patients with low PD-L1 expression is not well understood.

AIMS:
This study aimed to observe the efficacy of envafolimab in gastric adenocarcinoma with
low PD-L1 expression and explore the underlying mechanisms.

Objective:
The objective of this study was to explore the underlying mechanism of envafolimab in
gastric cancer with low PD-L1 expression.

Method:
Cytotoxicity and proliferation were evaluated by a CCK8 assay. Transwell assays were
used to detect the migration and invasion ability of gastric cancer cells. The effect of envafolimab
on the apoptosis of gastric cancer cells was detected by flow cytometry. The effect of envafolimab
on gastric cancer cells with low PD-L1 expression was investigated via proteomics and bioinformatics analysis.

Result:
A total of 19 patients with advanced gastric adenocarcinoma who received envafolimab
monotherapy or combination therapy were reviewed. Among them, 4 patients had low PD-L1 expression, the objective response rate (ORR) was 75% (3/4), and the disease control rate (DCR)
was 100% (4/4). In vitro experiments showed that envafolimab inhibited the proliferation, invasion, and migration of gastric cancer cells with low expression of PD-L1 and induced cell apoptosis. DDX20 may be the target of envafolimab in gastric cancer cells, and it is related to the NF-κB
signaling pathway. Western blot results showed that the protein expressions of DDX20, NF-κB
p65, and TNF-α in gastric cancer cells were decreased after adding envafolimab. Furthermore, the
DDX20 gene was silenced by small interfering RNA to further study the effect of DDX20 on PDL1 low expression in gastric cancer cells.

Conclusion:
This study confirmed that envafolimab could inhibit the growth of gastric cancer
cells with low PD-L1 expression by down-regulating DDX20 expression and regulating the NFκB/TNF-α signaling pathway.
Magnesium Regulates the Migration and Differentiation of NPMSCs via the Integrin Signaling Pathway
Authors: Yin Dong , Huang Chongquan , Liang Changxiang , Zhuang Jianxiong , Chen Haobin , He Yue , Yu Hui , Xiao Jin , Huang Yongxiong , Zhou Jielong , Chen Xiangting 
Published: July 2024

Background:
Nucleus pulposus mesenchymal stem cells play a fatal role in intervertebral
disc homeostasis. Magnesium is an essential bioactive element for the human body, regulating
intracellular enzyme activity and promoting stem cell adhesion and differentiation.

Objective:
This study aimed to detect the effects of Mg2+ on nucleus pulposus mesenchymal stem
cells and explore the mechanism by which magnesium ions promote the differentiation of nucleus
pulposus mesenchymal stem cells.

Methods:
Nucleus pulposus mesenchymal stem cells digested from the caudal intervertebral disc
of 3-month-old SD rats were interfered with using different concentrations of magnesium ions,
and their levels of migration, adhesion, and differentiation were evaluated by biochemical and
molecular indices.

Results:
Magnesium ion treatment significantly enhanced the migration and adhesion ability of
NPMSCs. Meanwhile, magnesium ion treatment promoted NP differentiation of NPMSCs and the
formation of nucleus pulposus precipitates. p-Smad2 immunofluorescence staining demonstrated
that the nuclear translocation of p-Smad2 was significantly up-regulated after Mg2+ stimulation,
while this effect was significantly attenuated by the addition of β1 blocker. In addition, protein
quantification experiments demonstrated the same results. These results showed that 10mM magnesium
can significantly promote the differentiation of NPMSCs, and its mechanism is related to
the integrin receptor and TGF-β signaling pathway.

Conclusion:
Mg2+ at 10 mM significantly promoted migration and differentiation of NPMSCs by
a mechanism related to the integrin-TGF signaling pathway.
RELASI SOSIAL AKIBAT PERGESERAN MAKNA SINOMAN
Authors: Rahmawati Dina , Hendrastomo Grendi 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui: 1) faktor penyebab pergeseran makna sinoman di Desa Sitimulyo; dan 2) dampak pergeseran makna sinoman di Desa Sitimulyo. Penelitian ini menggunakan metode kualitatif deskriptif dengan lokasi penelitian di Desa Sitimulyo Kecamatan Piyungan Kabupaten Bantul di Yogyakarta. Data dikumpulkan dengan observasi dan wawancara. Data dianalisis secara kualitatif menggunakan metode fenomenologi. Hasil penelitian menunjukkan bahwa faktor penyebab terjadinya pergeseran makna sinoman, yaitu: a) faktor kultural, meliputi menurunnya rasa gotong-royong dan budaya instan; b) faktor struktural, meliputi kurangnya sosialisasi sinoman terhadap generasi muda.; serta c) faktor pendidikan. Dampak pergeseran makna sinoman di Desa Sitimulyo, yaitu: a) hubungan antar individu yang kurang mengenal satu sama lain; b) munculnya sanksi “ora srawung, rabimu suwung”; c) terancamnya eksistensi tradisi sinoman.
STRATEGI TRANSGENDER MENGHADAPI DISKRIMINASI DALAM DUNIA KERJA SEKTOR INFORMAL
Authors: Orchitta Dhieta , Hidayah Nur , Martiana Aris 
Published: July 2024

Masalah mengenai transgender masih menimbulkan pro dan kontra ditengah masyarakat Kota Yogyakarta, transgender dianggap sebagai sebuah penyimpangan sosial. Penelitian ini bertujuan untuk mengetahui strategi transgender menghadapi diskriminasi dalam dunia kerja sektor informal di Kota Yogyakarta. Penelitian ini menggunakan metode kualitatif deskriptif dengan lokasi penelitian di Kota Yogyakarta. Informan dipilih dengan teknik purposive sampling. Metode pengumpulan data yang digunakan meliputi wawancara, observasi, dan dokumentasi. Keabsahan data diperiksa dengan menggunakan teknik triangulasi data. Teknik analisis data menggunakan model interaktif Miles dan Hubermen. Hasil dari penelitian menunjukkan bahwa transgender di Kota Yogyakarta dalam bekerja di sektor informal masih mendapatkan diskriminasi berupa : (1) cemoohan atau ejekan, (2) kekerasan fisik, (3) perkosaan, (4) tidak mendapatkan kesempatan kerja. Terdapat Strategi yang dilakukan transgender untuk menghadapi diskriminasi dalam dunia kerja sektor informal yaitu : (1) melakukan pendiaman dan pengertian singkat, (2) bekerja sama dengan lembaga terkait, dan (3) melakukan forum diskusi mengenai isu transgender.
Perubahan Sosial Masyarakat Pasca Adanya Pasar Sunday Morning di Padukuhan Kadisoka Purwomartani Sleman Yogyakarta
Authors: Sriyono Sriyono , Lestari Puji 
Published: July 2024

Pasar merupakan tempat untuk suatu proses interaksi penjual dan pembeli dari suatu barang dan jasa tertentu. Berdirinya sebuah sarana atau tempat baru seperti pasar disuatu wilayah tertentu akan menjadikan adanya perubahan sosial. Penelitian bertujuan untuk mengetahui latar belakang yang mempengaruhi berdirinya sebuah pasar yaitu Pasar Sunday Morning Kadisoka. Selain itu penelitian ini juga bertujuan untuk mengetahui bentuk perubahan sosial yang terjadi disekitar pasar tersebut. Penelitian ini menggunakan metode penelitian kualitatif deskriptif untuk mendeskripsikan mengenai perubahan sosial yang terjadi setelah berdirinya Pasar Sunday Morning Kadisoka. Penelitian ini difokuskan kepada masyarakat Padukuhan Kadisoka, penjual, dan pembeli yang datang ke pasar tersebut menggunakan teknik purposive sampling. Metode pengumpulan data yang digunakan meliputi observasi, wawancara, dokumentasi dan studi pustaka. Keabsahan data diperiksa dengan menggunakan teknik triangulasi data.Teknik analisis data menggunakan model interaktif Milles dan Huberman yaitu pengumpulan data, reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa berdirinya Pasar Sunday Morning Kadisoka dilatarbelakangi oleh beberapa hal. Hal tersebut diantaranya adanya keinginan masyarakat Padukuhan Kadisoka untuk menciptakan suatu kegiatan yang berguna dan dapat menambah pemasukan masyarakat. Dengan berdirinya Pasar Sunday Morning Kadisoka memberikan suatu perubahan sosial yang terlihat oleh masyarakat di Padukuhan Kadisoka dan sekitarnya. Bentuk perubahan sosial yang terjadi meliputi norma sosial, perilaku sosial, dan sikap sosisal. Dampak dari perubahan sosial tersebut dapat berupa dampak positif yaitu interaksi sosial yang lebih baik antar warga Kadisoka, menambah lapangan pekerjaan dan pendapatan, mengubah sikap sosial masyarakat Kadisoka menjadi lebih bertanggugjawab bersama dalam mengelola pasar Sunday Morning. Dampak negatif yaitu penebangan pohon kelapa untuk dijadikan lokasi pasar, masyarakat belum sepenuhnya siap dalam mengelola pasar mengenai penataan tempat parkir. Oleh karena itu, diperlukan strategi guna menyikapi dampak yang muncul pasca adanya pasar Sunday Morning Kadisoka.
PERSEPSI MASYARAKAT TERHADAP TRADISI SURONAN DI DUSUN PONGGOK PANDE, KELURAHAN TRIMULYO, KECAMATAN JETIS, KABUPATEN BANTUL
Authors: Istianah Khoirul , Lestaru Puji 
Published: July 2024

Penelitian ini bertujuan untuk mendeskripsikan bagaimana persepsi masyarakat terhadaptradisi Suronan dan juga melihat bagaimana bentuk partisipasi yang dilakukan olehmasyarakat pada tradisi Suronan. Penelitian ini menggunakan metode penelitian kualitatif.Subyek penelitian berjumlah 6 orang yang dipilih dengan teknik purposive sampling.Pengumpulan dalam data ini dilakukan dengan observasi, wawancara dan dokumentasi.Teknik validitas dalam penelitian ini menggunakan teknik triangulasi data. Penelitian inimenggunakan teknik analisis data secara interaktif dimulai dengan reduksi data, penyajiandata, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan bahwa terdapat beberapapersepsi yang muncul dalam masyarakat yang mana dalam persepsi tersebut masyarakatmenganggap bahwa Suronan sebagai tradisi Dusun Ponggok Pande yang syarat akan nilainilaisosial keagamaan. Selain hal tersebut dengan dilaksanakannya tradisi Suronan dapatmeningkatkan solidaritas dan sikap gotong royong antar warga masyarakat Dusun PonggokPande. Adapun bentuk partisipasi yang dilakukan oleh masyarakat Dusun Ponggok Pandepada tradisi Suronan diantaranya partisipasi dalam bentuk pikiran, tenaga, keahlian, barang,dan uang. Selain itu terdapat pula keterlibatan emosional dan keterlibatan mental masyarakatdalam tradisi Suronan.Kata Kunci: Tradisi Suronan, Persepsi, Partisipasi
Prevalence of Stunting and Associated Factors Among Under Five Years Children in Galkaio Town, Puntland, Somalia 2023: A cross-sectional study design
Authors: Ahmed Mohyadin Abdullahi , Duale Fatima Said , Ali Musatafe Abdi , Ibrahim Ahmed Mohammed 
Published: July 2024

Background: Stunting is a frequent dietary issue that mostly affects less industrialized countries, such as Somalia. Even so, the Somali government has made some progress towards achieving the target for stunting, but still, 25.3% of children under five years old are stunted. If the annual decreasing proportion continues at this rate, Somalia will not be able to meet the established target set by the WHO in 2012, which was to reduce stunting by 40% by 2025. Therefore, this study aimed to assess the prevalence and associated factors of stunting among children aged 6-59 months.
Methods and materials: A cross-sectional study with a community focus was carried out. among 362 children aged 6–59 months matched with mothers and caregivers. Districts served as first-stage units, villages served as second-stage units, and houses served as third-stage units in the multistage sampling technique. A structured questionnaire was used, and the mothers and caregivers were interviewed. Standardized anthropometric measurements were used to measure the child’s height. Version 3.1 of Epi Data was used to enter the data, and SPSS version 20 was used for analysis.
Result: The overall prevalence of stunting among children between the ages of 6 and 59 months in this study was 37.3%, 95% CI (32.6–42.5). Polygamous marriage to father [AOR = 2.824; 95% CI: (1.60, 4.98)], educational status of mother [AOR = 2.502; 95% CI: (1.28, 4.90)], sex of child [AOR = 2.079; 95% CI: (1.27, 3.41)], time to initiation of breastfeeding [AOR = 3.212; 95% CI: (1.95, 5.29)], exclusive breastfeeding [AOR = 1.725; 95% CI: (1.01, 2.96)], minimum dietary diversity score [AOR = 2.579; 95% CI: (1.30, 5.28)], and postnatal care visits of mothers [AOR = 2.688; 95% CI: (1.60, 4.52)] were significantly associated with stunting.
Conclusion: The prevalence of stunting among children aged 6–59 months was higher than that among the national population. The polygamous marriage of the father, educational status of the mother, sex of the child, time for initiation of breastfeeding, exclusive breastfeeding, minimum dietary diversity score, and postnatal care visits of the mother were significantly associated with stunting.
Method Development and Validation for Estimation of Etifoxine in Capsule Dosage Form by Using RP-HPLC/UV
Authors: Laharika Choudary Mannava , Srinivas Medidi , Udaya Kumari Bula 
Published: July 2024

A RP-HPLC/UV method was developed and validated to quantify the etifoxine in capsule dosage form. The chromatographic separation was carried out using a Hypersil ODS C18 column (250×4.6 mm, 5 μm) with a mobile phase consisting of an ammonium acetate buffer: acetonitrile in a volumetric ratio of 40:60%. The UV wavelength chosen for detection was at 255 nm. The flow rate was set at 1 ml/min. The retention time for etifoxine was determined to be 2.074 min. Linearity was detected within the concentration range of 7.5-45 μg/mL for etifoxine. The approach has been confirmed to be linear, accurate, precise, robust, and has established limits of detection and quantitation. The established procedure was uncomplicated, cost-effective, and suitable for the routine analysis of etifoxine in capsule dosage form.
Pemanfaatan Media Instagram Sebagai Media Informasi Mesjid Darul Hasani di Desa Miruek Taman Kabupaten Aceh Besar
Authors: Ibrahim Malik , Salsabila Annisa , Azmul Fauza  , Dara Julana  , Devista Sari  , Fazira Putri Salsabila  , Nanang Restu Pradana  , Putri Ronadzafira  , Rahil Naila  , Rahil Naila  , Rayhan Juliansyah  , Susan Fariaton  
Published: July 2024

Penelitian ini bertujuan untuk menggali pengalaman dan presepsi individu seseorang yang mengikuti akun media Instagram Mesjid Darul Hasani di Desa Mireuk Taman Aceh Besar demi mendapatkan informasi. Metode yang digunakan dalam penelitian ini adalah kualitatif dengan pendekatan teori fenomenologi. Data dikumpulkan melalui wawancara mendalam dengan pengguna Instagram yang merupakan masyarakat desa yang aktif mengikuti akun instagram Mesjid dan mengamati kontennya. Hasil penelitian ini mengungkapkan bahwa pengguna Instagram mengalami pengalaman yang beragam dalam mendapatkan informasi tentang Mesjid Darul Hasani Mireuk Taman. Baik itu informasi umum maupun edukasi seputar agama yang didapatkan di media sosial khususnya instagram.
GLOCALIZATION OF WALI SONGO ISLAMIZATION IN 15TH – 16TH CENTURIES
Authors: Hak Nurul 
Published: July 2024

Wali Songo’s Islamization has been identical to the Islamization of the Island of Java. This assumption, however, holds as if Wali Songo’s venture was confined locally to Java while such a process encompassed the Archipelago and beyond. This article aims to reconstruct the Wali Songo's Islamization from glocalization perspective, by involving both local and global phenomenon of the Islamization processes.To further analyze the Islamization, this study uses geo politics and cultural diffusion theories. Data in this study was collected using historical methods consisting of heuristics, source criticism, interpretation, and historiography. The results of this study showed two findings. First of all that Wali Songo Islamization constituted cosmopolitan Islam, indicated by process of Wali Songo Islamization that was not only local Java but also regional (Nusantara) and global ones.Wali Songo Islamization of local Java took the micro areas of the preaching and spreading Islam in the region, including East Java, Central Java and West Java. While the Islamization of regional and global took macro areas as the networking strategies of the preaching Islam in the region, indicated by the integration between global and local (glocalization) processes of the Islamization. Second, the glocalization of Wali Songo Islamization could be understood by emplacing the Islamization as World History of Islam in Medieval Period using multi-perspectives.
THINK GLOBALLY, ACT LOCALLY! LINGUISTIC AS A PROMOTIONAL STRATEGY BY MULTI-NATIONAL FAST FOOD CHAINS : A CASE OF INDONESIA
Authors: Pradani Eka Septi 
Published: July 2024

This research discusses how international fast food chains employ glocal strategies to promote and localize their brands in Indonesia. International fast food chains primarily utilize advertisements in their target country's language. The aim is to analyze the language used in advertisements on their official Instagram accounts and to examine how local languages are employed during special events in Indonesia. This becomes an important strategy in promoting their products through the incorporation of local languages in advertisements. A qualitative research approach was employed to analyze advertisements and to answer the research questions. The theoretical framework is based on Robertson’s (1980) conceptions of universalizing and particularizing tendencies, and on Fernandez's (2009) theory of 'Cultural Glocality' with a few modifications. The top five international fast food chains, including McDonald's, Dominos, KFC, Burger King, and Pizza Hut, were chosen for this reason. This study analyzed advertisements from January to April 2024. The findings reveal that multinational fast food chains are more popular in Indonesia because of the language they employ in their advertisements to attract and convey their message to their customers. The data analysis reveals that glocal strategies include employing local language(s), code switching, location, cultural/religious events, and language aspects in advertising. Using local language allows them to promote their products while simultaneously localize their brand in Indonesia.
INDIGENOUS FASHION OF SEMIOTIC AT DANI TRIBE IN WAMENA PAPUA HIGHLAND
Authors: Halitopo Manase , Kogoya Napius 
Published: July 2024

Papua Island has many ethnic groups, one of them is Dani tribe which is located in the Highland of Papua Province. The objectives of this research were to recognize the semiotics meaning of the form and size in the Dani tribe. In addition, the researcher took the data from the elders who have grown up and the stakeholders in the Wamena city. In collecting data, the researcher did the observation, interview, and documentation. In analyzing the data, the researcher used the data condensation, data display, and the verifying. Therefore, the result showed that there are some traditional fashion used by men such as Werene Puali (Parrot), Siluki (Fox tail), Kena Esi (Cockatoo feather), Werene Kare (Parrot feather), Hupa Eken (Grain of wheat), Sisika (Eagle feather), Besi (Charcoal of grass), Inyelak Pisik (Yellow clay), Wam Aek (Pork fang), Melaik (Small white tie), Walimo (Long tie), Yalema Esi (The back necklace), Yeke esi (Bracelet), Sege (Spear), Sike (Arrow), Tok eken (Bow), Holim (Water Gourd), and Saniken (Belt) and the women tradition fashion were Sali (Skirt for unmarried women), Yokal (Skirt for marriade women), and Sekan (Bracelet), Inyelak Pisik (Yellow clay), Traditional Bag (Su).
Pembelajaran Mesin Berbasis E-nose Untuk Klasifikasi Daging Pada Produk Sosis
Authors: Sumanto Budi , Abelta Mika Setiarini  , Alfonzo Aruga Paripurna Barus  , Iman Sabarisman  , Muhammad Arrofiq  
Published: July 2024

Makanan cepat saji yang disebut sosis memiliki berbagai jenis rasa berdasarkan jenis daging yang digunakan. Identitas jenis daging sangat penting untuk memastikan kualitas bahan dan kehalalan produk makanan. Tujuan dari penelitian ini adalah untuk mempelajari kinerja hidung elektronik (e-nose) yang terdiri dari enam sensor berbasis metal oxide semiconductor (MOS) terhadap sampel sosis dengan bahan dari daging babi, sapi, dan ayam yang dibuat tanpa campuran bumbu atau rempah. Eksperimen pengukuran dengan e-nose dilakukan pada suhu ruangan sebanyak seratus kali perulangan untuk masing-masing jenis sosis. Metode ekstraksi ciri maksimum, median, skewnes, kurtosis, standar deviasi, dan varians digunakan untuk mengekstraksi hasil respon sinyal e-nose. Analisis yang dilakukan menggunkan principal component analysis (PCA) sebagai metode pengelompokan sedangkan metode klasifikasi menggunakan metode Linear discriminant analysis (LDA), k-nearest neighbor (k-NN), Quadratic Discriminant Analysis (QDA), Logistic Regresi (LR), dan Classification and Regression Trees (CART). Metode LDA memperoleh hasil yang paling akurat yaitu dengan akurasi internal mencapai 100% dan eksternal sebesar 98,3%. Sedangkan pengelompokan dengan PCA mampu memisahkan sosis berdasarkan jenis dagingnya dan juga menunjukkan adanya tumpang tindih data yang mengindikasikan ketiga sampel memiliki kesamaan profil aroma yang sama.
Pelatihan Pembuatan Alat Peraga Pembelajaran Matematika Berbasis STEM bagi Guru SD
Authors: Krisma Dita Aldila , Pradanti Paskalia 
Published: July 2024

Pelaksanaan pengabdian dengan kegiatan pelatihan pembuatan alat peraga berbasis STEM (Science, Technology, Engineering, and Mathematics) bagi guru Sekolah Dasar (SD) di lingkungan Kramat ini diadakan karena pengetahuan dan kemampuan guru dalam membuat alat peraga masih perlu ditingkatkan, belum semua guru pernah memperoleh pelatihan tentang alat peraga, dan ketersediaan alat peraga belum banyak variasi atau inovasi, serta keberadaan alat peraga yang sering ada hanya pada lingkup materi geometri. Pelatihan ini bertujuan untuk memberikan pelatihan kepada guru untuk membuat alat peraga, mengenalkan pembelajaran berbasis STEM di tingkat Sekolah Dasar, dan mengembangkan kemampuan keprofesian guru dengan membuat karya inovatif bagi guru-guru di SD Negeri Kramat 1 dan SD Negeri Kramat 5. Kegiatan ini dilakukan dengan metode pelatihan yang dilaksanakan dikedua SD tersebut. Metode pelaksanaan pengabdian ini terdiri dari tahapan persiapan, pelaksanaan, dan evaluasi. Daya tarik dan urgensi pengabdian ini adalah dibutuhkannya pelatihan pembuatan alat peraga yang inovatif bagi guru, mengenalkan inovasi melalui konsep Engineering Design Process pada alat peraga berbasis STEM kepada guru dengan adanya penyelidikan sains, konstruksi teknik, keterampilan teknologi, dan penalaran matematis, serta dibutuhkannya alat peraga bagi siswa SD untuk memfasilitasi pembelajaran sesuai tingkat kognitifnya. Hasil dari pengabdian ini adalah guru memahami pengertian alat peraga, manfaat alat peraga, dan pentingnya alat peraga bagi pembelajaran berbasis STEM mencakup pengertian pembelajaran berbasis STEM, perspektif STEM dalam 4 level, Engineering Design Process (EDP), dan contoh kegiatan STEM; guru dapat membuat alat peraga yang diintegrasikan dengan STEM, dan guru dapat melakukan simulasi penggunaan alat peraga yang dibuat. Program ini memberikan manfaat untuk menambah wawasan tentang karya inovatif bagi guru sehingga dapat guru dapat melakukan inovasi memanfaatkan sumber belajar yang ada di sekitar.