bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phasing and continuity of the treatment of thyroid eye disease in patients with Graves’ disease
Authors: Bessmertnaya E. G. , Mikheenkov A. A. , Kolodina A. S. , Aksenova T. N. , Babaeva D. M. , Grusha Ya. O. , Sviridenko N. Yu. 
Published: July 2024

According to modern concepts, thyroid eye disease (TED) is an independent progressive autoimmune disease of the organ of vision, closely associated with the autoimmune pathology of the thyroid gland (TG), (ICD code — H06.2, proptosis in case of impaired thyroid function E05.0). TED treatment is a long step-by-step process, including immunosuppressive therapy, radiation therapy of the orbits and surgical treatment.TED is a multidisciplinary problem. A patient with thyrotoxicosis clinic and TED symptoms will be taken to an endocrinological clinic for normalization of thyroid hormones and treatment of thyrotoxicosis complications. At the same time, under the supervision of an ophthalmologist, TED diagnostics and treatment will be carried out. Teamwork is of utmost importance because the effectiveness of TED treatment will depend on the speed of achieving a stable euthyroid state, the accuracy of determining the TED activity and severity, and the presence of complications requiring surgical treatment.There are two main phases in the TED development. In the first phase of active inflammation, an increase in the symptoms of TED occurs, then a plateau phase follows, when the symptoms of activity persist but do not progress, then the symptoms regress and the process becomes inactive, while visual disturbances and cosmetic defects may persist. Determining the TED activity is very important from a clinical point of view, because the choice of treatment and tactics of patient management depend on the inflammation activity.We describe a clinical case of phasing treatment of TED complicated by optic neuropathy and movement disorders in a patient with Graves’ disease, resistant to immunosuppressive therapy with glucocorticoids and requiring deep lateral bony orbital decompression.
Clinical and laboratory features of rheumatoid arthritis in men depending on testosterone levels
Authors: Panevin T. S. , Rozhivanov R. V. , Zotkin E. G. , Diatroptov M. E. , Glukhova S. I. , Samarkina E. Yu. 
Published: July 2024

BACKGROUND: It has been suggested that the presence of chronic immunoinflammatory rheumatic disease (CIRD) may be a factor that increases the likelihood of developing hypogonadism syndrome, and conversely, the presence of uncompensated testosterone deficiency may predispose to a greater risk of developing or more severe course of ICRD.AIM: To study the incidence of hypogonadism in men with rheumatoid arthritis (RA) and evaluate its impact on the course of RA and concomitant diseases.MATERIALS AND METHODS: A one-time continuous study included 170 men with RA who were undergoing inpatient treatment at the Federal State Budgetary Institution NIIR named after. V.A. Nasonova. Patients were assessed for total testosterone levels and subsequently divided into subgroups with normal (>12 nmol/l) and reduced levels. An intergroup comparison was carried out on the main indicators used in clinical rheumatological practice to assess the stage, activity and other medical and demographic characteristics of RA, as well as the state of purine and carbohydrate metabolism. A correlation analysis was performed between the level of total testosterone and some clinical and laboratory parameters.RESULTS: The frequency of detected testosterone deficiency in the study group was 24.1%. Significant correlations were noted between the level of total testosterone and body mass index (r=-0.29), the level of blood uric acid (r=-0.19) and C-reactive protein (r=-0.18). Patients with hypogonadism compared to the group with normal testosterone levels were characterized by higher body mass index (29.3±5.6 vs 26.3±4.0 kg/m2; p<0.001), glucose levels (6.95±7 .85 mmol/l vs 5.42±1.13 mmol/l; p=0.034) and uric acid (354.6±110.7 vs 317.5±84.8 µmol/l; p=0.03) blood. In addition, patients with hypogonadism were more likely to suffer from obesity (41.6% vs 15.7%; p=0.001) and diabetes mellitus (21.6% vs 10.2%; p=0.075) without a statistically significant difference, and also had higher ESR (46.5±42.2 vs 31.0±30.9 mm/h; p=0.012). A more frequent occurrence of anemia was noted in hypogonadism (32.4% vs 16.7%; p=0.041).CONCLUSION: Testosterone levels and the presence of hypogonadism were not associated with the stage and activity of RA, however, testosterone deficiency was accompanied by a more frequent development of overweight and obesity, and a deterioration in purine and carbohydrate metabolism.
Syndromic growth retardation caused by impaired function of the ribosomal protein eL13
Authors: Makretskaya N. A. , Vorontsova I. G. , Buianova A. A. , Korostin D. O. , Petryaykina E. E. , Tiulpakov A. N. 
Published: July 2024

Growth retardation for more than 2 SD below the average population or presumed familial target height is classified as a short stature and may be a clinical manifestation of a large number of disorders. The use of the latest methods of molecular genetic analysis in recent years has allowed for a better understanding of the pathogenesis of inherited forms of a short stature. One of the recently discovered mechanisms of this pathology was monoallelic mutations in RPL13 gene, leading to the development of Isidor-Toutain type spondyloepimetaphyseal dysplasia (SEDM). Characteristic phenotypic features for this form are normal birth length, early postnatal growth deficiency, platyspondyly, proximal femoral epiphyseal changes, coxa vara, genu varum. This study presents the clinical and radiological characteristics of the first patient in the Russian ­Federation with SEMD caused by a mutation in RPL13 gene.
Formation of Cultural Heritage Through the Interaction Between Chinese and Arab Cultures from a Post-colonial Perspective: Taking Ma Jian as an Example
Authors: Farghani Mohsin 
Published: July 2024

Abstract
Ma Jian brought a major transformation that had not been experienced in the early period of Chinese-Arab relations, which not only benefited from his study in Egypt, but also originated from the wave of cultural revival in Egypt and other Arab countries in the “post-colonialism” era. Ma Jian was fruitful in his life. Two of his most prominent achievements are: first, he completed the translation of the Chinese version of the Koran. With traditional Chinese thoughts (Confucianism, Taoism and Buddhism) as the root and classical Islamic thoughts as the guide, Ma Jian translated the Koran by integrating the identity characteristics of the Chinese nation with the spirit of Islam; second, he introduced Arabic into Chinese university education and compiled the first Arabic-Chinese dictionary. By establishing the Chinese-Arab cultural exchange base, Ma Jian effectively promoted the integration of the Chinese and Arab nations and multicultural exchanges and mutual learning and got rid of the “English hegemony”. At the same time, Ma Jian translated many ancient Chinese books into Arabic, which also laid the foundation for the establishment of “Sinology” in the Arab region.
“Alexandria Trilogy”: A Mirror of Variations in Group Relations in Egypt’s Modern Society
Authors: You Mei 
Published: July 2024

Abstract
Egyptian writer Ibrahim Abdel Meguid’s best-known works form the “Alexandria Trilogy”: No One Sleeps in Alexandria (1996), Birds of Amber (2000), and Clouds Over Alexandria (2011). The Trilogy is set in three important historical periods: the Second World War, the Suez Crisis in 1956, and the 1970s. It focuses on describing the rise and fall of Alexandria, an ancient and modern city, from its heyday to its decline, from diversity to extremes, thus reflecting the writer’s deep concern about the Islamic radical thoughts flooding the city. The city of Alexandria is the main place and clue that runs through the three novels from beginning to end. The writer compares the landscape of the same city in different periods in the Trilogy, giving the space the ability to speak for itself, and it fluctuates in the whirlpool of the times. Whether it is telling the fate of characters, recording the history of the city, or describing spatial changes, the core idea conveyed by the Trilogy is that the city has gradually evolved from an open and prosperous modern international city in the past into a depressing place of gloom, and its contemporary history holds a mirror up to the changing nature of ethnic relations in Egypt.
EFLM Task Force Preparation of Labs for Emergencies (TF-PLE) recommendations for reinforcing cyber-security and managing cyber-attacks in medical laboratories
Authors: Lippi Giuseppe , Akhvlediani Salome , Cadamuro Janne , Danese Elisa , García de Guadiana Romualdo Luis , Delacour Herve , Favaloro Emmanuel J. , Favresse Julien , Henry Brandon M. , Jovicic Snezana , Kütt Marge , Moreno y Banuls Laetitia , Ozben Tomris , Peretz Avi , Perovic Antonija , Thachil Jecko , Yucel Dogan , Plebani Mario 
Published: July 2024

Abstract
The healthcare systems are a prime target for cyber-attacks due to the sensitive nature of the information combined with the essential need for continuity of care. Medical laboratories are particularly vulnerable to cyber-attacks for a number of reasons, including the high level of information technology (IT), computerization and digitization. Based on reliable and widespread evidence that medical laboratories may be inadequately prepared for cyber-terrorism, a panel of experts of the Task Force Preparation of Labs for Emergencies (TF-PLE) of the European Federation of Clinical Chemistry and Laboratory Medicine (EFLM) has recognized the need to provide some general guidance that could help medical laboratories to be less vulnerable and better prepared for the dramatic circumstance of a disruptive cyber-attack, issuing a number of consensus recommendations, which are summarized and described in this opinion paper.
On relating quasi-static load threshold K1scc to K1c
Authors: Vasudevan Asuri K. , Kujawski Daniel , Latanision Ronald M. 
Published: July 2024

Abstract
It is common to observe that monotonic K1c (lab air) and K1scc (NaCl solution) decrease with increasing YS of an alloy. K1c is measured in lab air and K1scc in an aqueous solution such as NaCl. It is noted that K1c is not considered as a subcritical parameter while K1scc is. Interestingly, for a given alloy, both these parameters seem to be inter-related. That is, K1scc is linearly related to K1c, such that K1scc increases with increasing K1c. This may indicate that plasticity is affecting the K1scc behavior. This article looks into the conditions that affect K1scc for steels, Al-alloys, and Ti-alloys. This linear variation of K1scc with K1c seems to be independent of alloy YS, E, microstructure, and work hardening rate. This observation seems similar in all three systems of alloys. How these parameters are interrelated is analyzed and discussed in detail.
The impact of loading rate on chloride induced stress corrosion cracking of 304L stainless steel
Authors: Blust Sarah M. , Burns James T. 
Published: July 2024

Abstract
The influence of applied loading rate (dK/dt) on stress corrosion cracking (SCC) behavior in annealed 304L stainless steel immersed in 4.7 M MgCl2 solution was assessed at varying temperatures from 23 °C to 70 °C. Measured crack growth rates obtained under rising K loading (dK/dt > 0) are compared to those obtained during static K testing. A rising K-based loading protocol was found to yield more conservative crack growth rates across all temperatures, with the variation in crack growth rates (and therefore the dependence in loading rate) decreasing with increasing environmental severity.
Neutrosophic Inventory Management: A Cost-Effective Approach
Authors: Dubey Ankit , Kumar Ranjan 
Published: July 2024

Abstract
Classical inventory models (IM) serve as quantitative tools for determining the optimal order quantities, timing of orders, and safety stock levels for specific inventory items or item groups. Zadeh (1965. Fuzzy sets. Information and Control, 8, 338–353) introduced fuzzy theory and Dubois and Parade (1988. Fuzzy logic in expert systems: The role of uncertainty management. Fuzzy Sets and Systems, 28, 3–17) presented the study of fuzzy inventory model, which, however, exhibits limitations in effectively handling uncertainty, inaccuracies, and imprecise data. In 1999, Smarandache presented the idea of neutrosophic set theory to handle uncertainty. Using trapezoidal neutrosophic numbers, this study extends the idea of neutrosophic sets to inventory management, concentrating on resolving the uncertainty associated with holding costs, ordering costs, and shortage costs. First time within the literature of the neutrosophic set, our new method not only addresses existing problems but can also tackle other issues that no other authors have successfully resolved so far. Additionally, we conduct a comparative analysis of our proposed model against existing models in this article. Based on this comparative study, our findings assert the superior performance of our proposed model in relation to some of the existing models. In conclusion, we wrap up our research by presenting graphical, logical, and tabular comparisons with the existing methods.
Figures of discourse in prose fiction
Authors: Toker Leona 
Published: July 2024

Abstract
The essay demonstrates the relationship between specific figures of discourse dominant in particular novels and the thematic concerns or plot patterns of each individual novel. The figures discussed are (1) enthymeme, prominent in Laurence Sterne’s Tristram Shandy and important also in Joyce’s Ulysses; (2) hypallage, part of the rhetoric of Dickens’s A Tale of Two Cities, reflecting its plot pattern and its cluster of concerns; and (3) blazon, which helps to convey the implied author’s critique of the attitudes of the first-person narrator of Lolita.
Sensorless control method of induction motors with new feedback gain matrix and speed adaptive law for low speed range
Authors: Guo Leilei , Wang Shuai , Li Yanyan , Jin Xueyan , Chu Zhiyue 
Published: July 2024

AbstractThe conventional adaptive full-order observer-based speed sensorless control method for induction motor is prone to instability at low-speed region as improper feedback gain matrix and imprecise speed adaptive law are often used. To address these problems, a new feedback gain matrix design approach as well as a new speed adaptive law design technique are proposed in this paper. Firstly, considering that the d-axis current estimation error in the traditional feedback gain matrix design method has a great influence on the stability of the speed estimation algorithm, especially at low speeds, a new feedback gain matrix design method is proposed to minimize thed-axis current estimation error. Secondly, a new speed adaptive law design technique is studied based on the conventional method, which only requires thed-axis andq-axis current estimation error with a weight coefficient to be designed, simplifying the conventional speed adaptive law. Thirdly, the transfer function from the speed observation error to the proposed adaptive error is analyzed by Routh stability criterion theory, and the weight coefficient suitable for full range stable operation is determined by MATLAB software. Fourthly, the stability of the proposed method in this paper is analyzed using the poles distribution maps. Finally, the proposed method is experimentally verified based on a 2.2 kW induction motor experimental platform. The experimental results show that the proposed method can make the induction motor operate steadily at low-speed and zero-speed region with rated load. In addition, the proposed method has better anti-disturbance performance than the existing method.
On the grammaticalization of ġādi in Moroccan Arabic: new insights
Authors: Bozza Cristiana 
Published: July 2024

Abstract
This study deals with the grammaticalization of ġādi – i.e., the active participle form of a movement verb meaning ‘to go/leave/depart in the morning’ – in Moroccan Arabic, of which the relevant literature has evidenced its uses as a future marker, describing this case as an instance of the common path ‘go (to)’ > future. In the light of fresh data, we first review the already documented uses of ġādi as a future marker, and, secondly, present an original preliminary study of its emerging modal values. Finally, by analyzing the correlation between the future values and the modal values of ġādi, we focus on some issues related to its grammaticalization, including the importance of taking into account certain semantic features of the source lexeme so far underestimated, and of considering the co(n)text within which the whole grammaticalization takes place. Ultimately, we argue that a secondary grammaticalization towards epistemic modality is in progress.
Mind-body practices for people living with dementia and their family carers: a systematic review
Authors: van der Ploeg Eva S. , Bitane Rutger M. , Schoones Jan W. , Achterberg Wilco P. , Smaling Hanneke J.A. 
Published: July 2024

Abstract

Introduction
People with dementia and their family carers may benefit from non-pharmacological interventions, including mind-body (MB-) practices, which can improve physical and mental health by inducing relaxation. This systematic review provides an overview of availability and effects of MB-practices.

Content
The authors performed a systematic search in PubMed, Embase, Emcare, Web of Science, Cochrane Library, PsycINFO, China National Knowledge Infrastructure and Academic Search Premier on February 1, 2024. Research papers on MB-practices for people with dementia and/or their family carers in English, Chinese, Japanese, German, French and Dutch were included if a full text was available. Selection of included articles, data extraction and methodological quality assessments were conducted by two researchers.

Summary
Of the 130 included studies, 100 (77 %) were of high quality. Traditional Chinese Medicine (TCM) and touch interventions for people with dementia, and meditations for family carers resulted in improvements in respectively cognition and neuropsychiatric symptoms, and mental health. Lack of evidence for other MB-practices is related to small numbers of studies, fragmented use of outcome measures and mixed findings.

Outlook
MB-practices showed promising results. We recommend implementation and further research of TCM- and touch interventions for people with dementia as well as meditations for family carers. We suggest a cross-over of the promising results of one group to be studied in the other group.
Detecting outliers in case-control cohorts for improving deep learning networks on Schizophrenia prediction
Authors: Martins Daniel , Abbasi Maryam , Egas Conceição , Arrais Joel P. 
Published: July 2024

Abstract
This study delves into the intricate genetic and clinical aspects of Schizophrenia, a complex mental disorder with uncertain etiology. Deep Learning (DL) holds promise for analyzing large genomic datasets to uncover new risk factors. However, based on reports of non-negligible misdiagnosis rates for SCZ, case-control cohorts may contain outlying genetic profiles, hindering compelling performances of classification models. The research employed a case-control dataset sourced from the Swedish populace. A gene-annotation-based DL architecture was developed and employed in two stages. First, the model was trained on the entire dataset to highlight differences between cases and controls. Then, samples likely to be misclassified were excluded, and the model was retrained on the refined dataset for performance evaluation. The results indicate that SCZ prevalence and misdiagnosis rates can affect case-control cohorts, potentially compromising future studies reliant on such datasets. However, by detecting and filtering outliers, the study demonstrates the feasibility of adapting DL methodologies to large-scale biological problems, producing results more aligned with existing heritability estimates for SCZ. This approach not only advances the comprehension of the genetic background of SCZ but also opens doors for adapting DL techniques in complex research for precision medicine in mental health.
Sensing that Something is Wrong: On the Role of Senses in Sensemaking in Frontline Safety Work
Authors: Midtlyng Grethe 
Published: July 2024

Abstract
Based on an ethnography of work in a high-security prison, this article explores how safety practitioners develop specialised sensing skills through close engagement with their socio-material work environment and how they use these skills in constructing their understandings of what is going on in everyday work. The results make visible the potential role of the senses in how workers keep systems running, how they maintain safety in situations where quick reactions are needed and for the fast transition to more deliberate forms of sensemaking for early intervention. However, despite the importance prison officers ascribed to the use of the senses for their ability to work proactively, certain technologies seemed to reduce access to sensory inputs and thereby the ability to notice weak signals. This indicate challenges regarding embodied and tacit safety knowledge when more visible representations of safety are implemented. The article aims to contribute to a theoretical framework for understanding the role of senses in safety work through the concept of sensemaking as an embodied, socio-material process.
Adult endocrinologists’ perspectives on transitioning adolescent patients with congenital adrenal hyperplasia
Authors: Hall Mary-Frances E. , Kremen Jessica , Boskey Elizabeth R. , Tulimat Sam , Staffa Steven J. , Grimstad Frances 
Published: July 2024

Abstract

Objectives
The study aimed to evaluate adult endocrinologists’ perspectives on caring for patients with congenital adrenal hyperplasia (CAH) and views on their transition from pediatric to adult care.

Methods
An online survey was conducted among adult clinical endocrinologists at Harvard Medical School-affiliated hospitals from March to October 2022.

Results
Most participants (25/34, 73.5 %) treat patients with CAH and expressed moderate to high confidence (23/32, 71.9 %) in their care. Those that did not treat or accept referrals cited insufficient expertise, knowledge, and resources as reasons. Only half of respondents correctly answered at least 50 % of standard of care questions. The main transition of care barrier identified was the absence of standardized policies (12/34, 35.3 %).

Conclusions
Participants, though involved in care of patients with CAH, had varied responses to standard of care questions and transition of care barriers, emphasizing the need for standardized transition protocols and additional training to ensure up-to-date clinical knowledge.
Therapeutic strategies for primary heart involvement in systemic sclerosis
Authors: Batani Veronica , Dagna Lorenzo , De Luca Giacomo 
Published: July 2024

Abstract
Primary heart involvement (pHI) is frequent in systemic sclerosis (SSc), even though often underdiagnosed. SSc-pHI has been recently defined as cardiac abnormalities that are predominantly attributable to SSc rather than other causes and/or complications. SSc-pHI represents a major determinant of mortality in SSc, accounting alone for about 12% of disease-related deaths; its early recognition and promptly therapeutic interventions are therefore crucial. Both perfusion defects and myocardial inflammation contribute to the occurrence of myocardial fibrosis that precipitates myocardial remodeling, potentially leading to heart failure and arrhythmic complications. To date, clear evidence and guidelines for effectively managing SSc pHI are not established yet, resulting in a lack of a defined therapeutic algorithm. In this review we summarize the most recent scientific literature on the prevailing therapeutic strategies and interventions to manage SSc-pHI, with particular focus on therapeutic strategies to counteract the 3 major pathogenic events of the disease, i.e. microvascular damage, myocardial inflammation and myocardial fibrosis.