bluuebunny/crossref_metadata_2025_split huggingface dataset:
La médiation d’authenticité des substituts numériques
Authors: Tardy Cécile 
Published: September 2015

Ce chapitre porte sur la circulation sociale des collections patrimoniales photographiques d’un musée à partir de leur transformation en image numérique. La numérisation ne se pose pas comme une seule question de ressemblance avec l’objet patrimonial à représenter mais bien comme une question d’ordre communicationnelle. Car la numérisation modifie essentiellement la relation de la société au patrimoine dès lors que le substitut n’est plus conçu comme un seul support d’enregistrement pour des spécialistes mais un support de médiation du patrimoine pour les publics.L’analyse cherche à comprendre plus spécifiquement le problème posé à la médiation de la représentation du rapport à l’authenticité par le substitut numérique et non plus par l’objet patrimonial. Comment mettre en scène l’authenticité à partir des substituts de patrimoines ? La recherche est conduite à partir du cas de l’application Iphone Musée Urbain MTL présentée par le musée canadien d’histoire sociale McCord, consistant à faire projeter par l’usager les images des archives photographiques Notman dans la ville même de Montréal, sur le lieu original des prises de vue. L’enjeu est de poser le questionnement de la médiation de l’authenticité dans une situation où le musée pousse à l’extrême la logique d’usage de ses substituts en mobilisant leur capacité à la fois de réinvestissement dans des dispositifs informatiques à écran et de mobilité en dehors des murs de l’institution muséale.L’analyse rend compte de trois moments du processus au cours duquel s’instaurent les conditions de la transmission d’authenticité par les substituts : d’abord la mise en scène de la relation des substituts au monde d’origine des collections, qui allie spectacle technologique et tradition touristique ; ensuite l’opération de validation de l’authenticité patrimoniale par l’assemblage entre deux vues sur la ville, celle du passé donnée par chaque substitut et celle présente et actuelle ; enfin la représentation de la présence de l’institution muséale comme garante de l’authenticité de la relation entre le substitut et le monde d’origine des collections.Au cours de ce processus de médiation en milieu urbain, l’analyse montre que les substituts sont désormais associés à des logiques de marque muséale.
Comparison of Mono- to Diphosphate Ester Ratio in Inhibitor Formulations for Mitigation of Under Deposit Corrosion
Authors: Brown Bruce , Saleh Amr , Moloney Jeremy 
Published: September 2015

Mitigation of localized under deposit corrosion (UDC) in upstream oil and gas pipelines is an important research topic for both industry and academia. In a research program to better define the various inhibitor components that provide mitigation of UDC, this initial research investigates the effect of varied ratios of mono- to dinonylphenol phosphate esters (PE) by testing a set of specifically formulated inhibitors. Inhibitors with three mono- to di-PE ratios were tested in the presence and absence of 2-mercaptoethanol (ME). Using two 1.25 in (3.18 cm) diameter API 5L X65 pipeline steel samples and 250 μm silica sand, UDC testing was conducted for 28 d in a CO2 saturated solution at 70°C and 1 bar (100 kPa) total pressure. Analysis has shown that localized corrosion (pit penetration rate) increased for ME-free nonylphenol PE as the concentrations of di-PEs and mono-PEs approached equivalency. The nonylphenol PE inhibitor with a 50:50 mono- to di-PE ratio at 100 ppm concentration failed to protect the surface of the sample under the individual sand grains. Even the base product inhibitor package with no PE provided better mitigation under these test conditions than the 50:50 mono- to dinonylphenol PE. However, it was observed that the addition of ME provided a dramatic improvement in the mitigation of UDC for each mono- to di-PE ratio of the nonylphenol PE tested. From this research, it is seen that the mono- to di- PE ratio is important to consider when developing corrosion inhibitors containing PEs.
Pharmacy Naloxone Standing Order and Community Opioid Fatality Rates Over Time
Authors: Xuan Ziming , Walley Alexander Y. , Yan Shapei , Chatterjee Avik , Green Traci G. , Pollini Robin A. 
Published: August 2024

ImportanceDespite the proliferation of pharmacy standing-order naloxone dispensing across many US states before the change to over-the-counter status, few policy analyses have evaluated the implementation of pharmacy naloxone standing orders in addressing opioid overdose fatality among communities.ObjectiveTo determine whether the implementation of pharmacy standing-order naloxone was associated with lower opioid fatality rates compared with communities without pharmacies with standing-order naloxone.Design, Setting, and ParticipantsThis retrospective multisite study was conducted with an interrupted time series analysis across 351 municipalities in Massachusetts over 24 quarters (from January 1, 2013, through December 31, 2018). Standing-order naloxone dispensing data were collected from 2 sources for all major chain pharmacies and many independent pharmacies, covering 70% of retail pharmacies in Massachusetts. Municipalities had various standing-order naloxone implementation inceptions during the study period. Data were analyzed from December 2021 to November 2023.ExposureThe main exposure was measured by the first quarter with standing-order naloxone dispensation as the actual implementation inception.Main Outcomes and MeasuresThe primary study outcome was municipal opioid fatality rate per 100 000 population obtained from the Massachusetts Registry of Vital Records and Statistics.ResultsThe median (IQR) population size across 351 municipalities was 10 314 (3635 to 21 781) people, with mean (SD) proportion of female individuals was 51.1% (2.8 percentage points). Pharmacies from 214 municipalities (60.9%) reported dispensing standing-order naloxone over the study period. At the baseline of the first quarter of 2013, municipalities that eventually had standing-order naloxone had greater quarterly opioid fatality rates compared with those that never implemented standing-order naloxone (3.51 vs 1.03 deaths per 100 000 population; P &amp;lt; .001). After adjusting for municipal-level sociodemographic and opioid prevention factors, there was significant slope decrease of opioid fatality rates (annualized rate ratio, 0.84; 95% CI, 0.78-0.91; P &amp;lt; .001) following standing-order naloxone dispensing, compared with the municipalities that did not implement standing-order naloxone. There were no significant level changes of opioid fatality rates in the adjusted models. Sensitivity analyses yielded similar and significant findings.Conclusions and RelevanceThese findings suggest that community pharmacy dispensing of naloxone with standing orders was associated with a relative, gradual, and significant decrease in opioid fatality rates compared with communities that did not implement the standing-order naloxone program. These findings support the expansion of naloxone access, including over-the-counter naloxone as part of a multifaceted approach to address opioid overdose.
Negative Life Events and Emotional Symptoms From Ages 2 to 30 Years
Authors: Copeland William E. , Keen Ryan , Tong Guangyu , Shanahan Lilly 
Published: August 2024

ImportanceExposure to different types of negative life events, including traumatic events, is common across the lifespan and associated with increased mental health symptoms.ObjectiveTo assess whether vulnerability to negative life events varies across 5 developmental periods from preschool to young adulthood.Design, Setting, and ParticipantsThis cohort study analyzed data from 3 community-representative studies set in the southeastern US (1992-2015) with harmonized assessment approaches that included a total of 13 775 assessments of individuals aged 2 to 30 years with up to 21 years of follow-up. Data analysis occurred from July 2023 to June 2024.ExposuresEach study assessed lifetime exposure to (1) traumatic events (ie, severe events associated with posttraumatic stress disorder) and (2) recent stressful events (eg, loss of a friend or moving). All assessments were completed with structured interviews with participants and/or their caregivers.Main Outcomes and MeasuresThe primary outcome was emotional symptoms (ie, anxiety and depressive symptoms). Associations of both categories of life events with emotional symptoms were compared across preschool (&amp;lt;7 years), childhood (7-12 years), adolescence (13-17 years), late adolescence (18-22 years), and young adulthood (23-30 years).ResultsAnalyses were based on 13 775 assessments of 3258 participants (1519 female [weighted percentage, 50.0%]). Recent stressful events were associated with emotional symptoms across each developmental period, ranging from a low in preschool (B =0.14; SE = 0.05) to a high in young adulthood (B = 0.57; SE = 0.12) in cross-sectional analyses and ranging from a low in childhood (B = 0.10; SE = 0.06) to a high adolescence (B = 0.19; SE = 0.05) in longitudinal analyses. Lifetime traumatic events were associated with emotional symptoms across each developmental period, ranging from a low in preschool (B = 0.18; SE = 0.05) to a high in adolescence (B = 0.28; SE = 0.04) in cross-sectional analyses and ranging from a low in childhood (B = 0.09; SE = 0.06) to a high in late adolescence (B = 0.21; SE = 0.05) in longitudinal analyses. Associations had overlapping 95% CIs across the different developmental periods with one exception: stressful events had a larger-magnitude cross-sectional association with emotional symptoms in young adulthood than in other developmental periods. Results were consistent with additive, rather than interactive, associations of traumatic and stressful events with emotional symptoms at each developmental period.Conclusions and RelevanceIn this cohort study of 3 community-representative samples, vulnerability to traumatic and stressful events was generally similar across the first 3 decades of life; both types of events had an independent association with emotional functioning. These findings suggest response to stressful events is similar from childhood to adulthood.
Considerations for the Use of the DNA Damage Marker γ‐H2AX in Disease Modeling, Detection, Diagnosis, and Prognosis
Authors: Hosking Holly , Pederick Wayne , Neilsen Paul , Fenning Andrew 
Published: August 2024

ABSTRACTBackgroundDNA double‐strand breaks are known to be the most lethal kind of DNA damage as they cause genomic instability. Visualization and quantification of these breaks are possible via staining of the phosphorylated histone H2A variant H2AX at serine 139 with the anti‐phospho‐histone H2AX (γ‐H2AX) antibody.MethodsThe literature was searched with the following keywords: DNA damage, double‐strand break, PBMC, DNA repair, H2AX, γ‐H2AX.DiscussionThis review discusses various methods for the quantification of γ‐H2AX and the use of γ‐H2AX in cell culture, tissue biopsies, and peripheral blood mononuclear cells. The current research into basal DNA damage as quantified by γ‐H2AX is discussed in relation to cancer.ConclusionsThis review suggests that γ‐H2AX has the potential for use in the prediction of cancer risk when applied to healthy tissue and peripheral blood mononuclear cells.
Edible Ultralong Organic Phosphorescent Excipient for Afterglow Visualizing the Quality of Tablets
Authors: Peng Yayun , Yao Xiaokang , Hu Xiwen , Wu Beishen , Pei Xiangyu , Yang Yuhan , Dong Zaiqing , An Zhongfu , Huang Wei , Cai Ting 
Published: August 2024

AbstractStimuli‐responsive ultralong organic phosphorescence (UOP) materials that in response to external factors such as light, heat, and atmosphere have raised a tremendous research interest in fields of optoelectronics, anticounterfeiting labeling, biosensing, and bioimaging. However, for practical applications in life and health fields, some fundamental requirements such as biocompatibility and biodegradability are still challenging for conventional inorganic and aromatic‐based stimuli‐responsive UOP systems. Herein, an edible excipient, sodium carboxymethyl cellulose (SCC), of which UOP properties exhibit intrinsically multistimuli responses to excited wavelength, pressure, and moisture, is reported. Impressively, as a UOP probe, SCC enables nondestructive detection of hardness with superb contrast (signal‐to‐background ratio up to 120), while exhibiting a response sensitivity to moisture that is more than 5.0 times higher than that observed in conventional fluorescence. Additionally, its applicability for hardness monitoring and high‐moisture warning for tablets containing a moisture‐sensitive drug, with the quality of the drug being determinable through the naked‐eye visible UOP, is demonstrated. This work not only elucidates the reason for stimulative corresponding properties in SCC but also makes a major step forward in extending the potential applications of stimuli‐responsive UOP materials in manufacturing high‐quality and safe medicine.
Evaluation of oil transesterification in a packed‐bed reactor containing lipase immobilized in starch–alginate jet cutting beads
Authors: Almeida Francisco Lucas Chaves , Sampaio Klicia Araujo , Prata Ana Silvia , Forte Marcus Bruno Soares 
Published: August 2024

AbstractThere has been a growing interest in ecofriendly enzymatic processes. However, enzyme solubility limits the application of many biocatalysts in continuous systems, requiring the development of cost‐effective strategies for enzyme immobilization. Based on this premise, this study investigated the application of lipase immobilized in starch–alginate beads for oil transesterification in a tubular reactor. An economical derivative was produced by immobilizing Eversa Transform 2.0 in 50:50 (w/w) starch–alginate beads using the jet‐cutting technique. The biocatalyst had a particle size of about 500 μm and activity of 138.67 ± 18.53 U g−1. X‐ray photoelectron spectroscopy showed nitrogen content ranging from 6.38% to 7.29%, with uniform distribution of lipase throughout the beads. Nitrogen isotherms were characteristic of mesoporous materials, with an average pore diameter of 48.09 Å and low surface area (0.69 m2 g−1). A face‐centered central composite design was used to study soybean oil transesterification. In the best four runs, the process achieved a mean triglyceride conversion of 45%. High ester productivity levels (2.05 × 10−2% ester g−1 biocatalyst min−1 or 1.5 × 10−4% ester U−1 min−1) were obtained. Biocatalyst reuse led to a twofold increase in ester concentration (14.57% vs 7.7%). These findings confirm the successful development of a low‐cost biocatalyst suitable for use in continuous reactions.
Meta‐analysis of contrast‐enhanced ultrasound in differential diagnosis of breast adenosis and breast cancer
Authors: Zhang Na , Sun Limin , Chen Xing , Song Hanxing , Wang Wenyu , Sun Hui 
Published: August 2024

AbstractThis systematic review and meta‐analysis study aimed to determine the total capacity of contrast‐enhanced ultrasound (CEUS) in the differential diagnosis of breast lesions and breast cancer. For collecting papers, four groups of keywords were searched in five databases. The required information was extracted from the selected papers. In addition to the descriptive findings, a meta‐analysis was also conducted. Thirty‐three of thirty‐six studies (91.67%) on the differential diagnosis of various degrees and types of breast lesions showed that CEUS has proper performance. The pooled values related to the sensitivity and specificity of CEUS were computed by 88.00 and 76.17.
How effective are church‐based weight‐loss interventions among Black adults? A systematic review
Authors: Williams Lovoria B. , Abu Farsakh Bassema , Karle Erika R. , Almogheer Zainab S. , Coughlin Steven , Kim Yeary Karen H. 
Published: August 2024

AbstractObjectiveChurches are frequently used to reach Black adults to effect weight loss. However, there has been no recent review, to our knowledge, inclusive of solely Black adults in church settings. We sought to comprehensively examine the methodological approaches and weight‐loss outcomes of church‐based weight‐loss lifestyle interventions conducted among Black adults to provide insights on literature gaps and offer suggestions for future research.MethodsGoogle Scholar, PubMed, and CINAHL (Cumulative Index to Nursing and Allied Health Literature) were searched for trials conducted in churches that reported weight outcomes at any time point. The Preferred Reporting Items for Systematic Reviews and Meta‐analyses (PRISMA) guided manuscript development.ResultsA total of 15 studies (N = 2285) from 2007 to 2023 met inclusion criteria, and 33% were high‐quality randomized trials. The majority were pilot studies (60%) conducted in the Southern United States. Most reported significant postintervention weight loss. The follow‐up time points varied from 2 to 12 months. Methodological approaches included the following: cultural adaptations (93%); theory‐guided (93%); delivered by community health workers (80%); and delivered in person in a group format (100%). Only one study offered individual‐level attention beyond texts/emails. Most participants were well‐educated female individuals.ConclusionsWeight‐loss interventions among Black church settings effect statistically significant weight loss, albeit in a small way. Limitations include pilot studies and small samples. More rigorously designed studies are warranted.
Antioxidant and Antitumor Potential of Some Benzoxazines Against MCF‐7 Cell Lines Using InVitro and InSilico Approaches
Authors: Mouada Hanane , Hachama Kamel , Zafar Imran , Stiti Mohamed Zakaria , Babar Samra , Khodja Mohamed 
Published: August 2024

AbstractCancer remains a severe global health problem, with its incidence constantly increasing.. Among many varieties of cancer, breast cancer persists as a prevalent global health concern, with its occurrence continually ascending. Among women, breast cancer is a significant cause of illness and death globally. This study examined the antioxidant and anticancer effects of two resynthesized benzoxazine derivatives, OBOP‐01 and OBOP‐02, on human breast cancer cells. The chemicals investigated had intense antioxidant action against DPPH, H2O2, and ABTS free radicals. Furthermore, we evaluated cell viability by converting yellow MTT (3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide) into purple formazan, dependent on mitochondrial function. Both compounds had IC50 values of 1.52±0.02 mM and 1.72±0.02 mM respectively. Moreover, toxicity predictions using the ProTox‐III webserver showed that the benzoxazines studied have lower LD50 values compared to doxorubicin, suggesting greater safety. We also used Density Functional Theory (DFT) to analyze OBOP‐01 and OBOP‐02′s electrical interactions and properties. Gaining insight into these interactions is essential for understanding the compounds′ potential applications and properties. According to theoretical studies using molecular docking, the derivatives may interact with estrogen receptor alpha (ERα) (ID: 7NDO), a key target molecule in the development of breast cancer. Additionally, the complex OBOP‐01 – ERα′s molecular dynamics simulations were conducted for 100 nanoseconds. These simulations revealed essential details regarding the complex's dynamic behavior in a physiological system.
Iterative Mathematical Models Based on Curves and Applications to Coastal Profiles
Authors: Caldarola Fabio , Carini Manuela , Maiolo Mario , Papaleo Maria Anastasia 
Published: August 2024

AbstractThe objective of this study is iterative systems based on general types of curves, not only on circumference arcs. We begin by presenting some implementations and generalizations of constructions based on arcs of circumference. Then we consider constructions based on general curves and give a “universal property” relating to the primary construction that exploits arcs of circumference. With the prospect of applying these theoretical models also to coastal geomorphology in the future, and inspired by one of the best-known models on the subject, the logarithmic spiral one for the so-called headland-bay beaches (HBBs), we study geometrically some cases in which the constructions are based on arcs of the golden spiral. Simultaneously we concretely illustrate and explain the universal property above. Finally we dedicate a section to discuss the possibility of how to numerically evaluate and compare the (infinite) lengths originating from our theoretical geometric constructions. Some explicit examples, calculations and comparisons will be provided by the use of infinity computing which is one of the various possible assets that contemporary non-standard mathematics makes available.
What are the functional outcomes and service experiences of patients with head and neck cancer treated during the COVID-19 pandemic?
Authors: Day Sarah , Mabb Kira , Nixon Jodie , Williames Jocelyn , Emlyn-Jones Mair , Davis Kate , Barrett Christie , Wishart Laurelie , Brown Bena 
Published: August 2024

Abstract
Introduction
Head and neck cancer (HNC) care was significantly impacted by the COVID-19 pandemic. The current study aimed to explore the functional outcomes and service experiences of patients with HNC treated during and prior the COVID-19 pandemic.

Methods
Mixed methods were used to (1) retrospectively compare HNC patients’ functional outcomes and allied health service usage across two time-controlled cohorts and (2) understand the experiences of HNC care using validated surveys and qualitative interviews.

Results
Retrospective data was extracted for 78 participants (pre-COVID-19, n = 43; during-COVID-19, n = 35), with n = 28 and n = 18 completing surveys and an interview, respectively. Significant differences were found in service modality between groups with significantly more phone and telehealth services provided during COVID-19. Service usage and functional outcomes were not significantly different between groups. During-COVID-19 participants reported being significantly less informed about their care and care was significantly less appropriate and acceptable. Thematic analysis of interviews revealed six broad themes related to communication, person-centred care, treatment logistics, care availability, safety of care, and impacts on experiences.

Conclusions
This study revealed that whilst HNC care rapidly changed at the onset of COVID-19, patient access to treatment and functional outcomes did not differ significantly. Rather, factors related to the patient experience of care were discussed. Healthcare professionals working in HNC have further evidence supporting building relationships based on transparent communication and partnering with patients to overcome rapid clinical changes, as experienced during COVID-19.
Towards modeling and analysis of longitudinal social networks
Authors: Dörpinghaus Jens , Weil Vera , Sommer Martin W. 
Published: August 2024

AbstractThere are various methods for handling longitudinal data in graphs and social networks, all of which have an impact on the algorithms used in data analysis. This article provides an overview of limitations, potential solutions, and unanswered questions regarding different temporal data schemas in social networks that are comparable to existing techniques. Restricting algorithms to a specific time point or layer has no effect on the results. However, when applying these approaches to a network with multiple time points, adjusted algorithms or reinterpretation becomes necessary. Therefore, using a generic definition of temporal networks as one graph, we aim to explore how we could analyze longitudinal social networks with centrality measures. Additionally, we introduce two new measures, “importance” and “change”, to identify nodes with specific behaviors. We provide case studies featuring three different real-world networks exhibiting both limitations and benefits of the novel approach. Furthermore, we present techniques to estimate variations in importance and degree centrality over time.