bluuebunny/crossref_metadata_2025_split huggingface dataset:
When reasons run out
Authors: Kay Jason 
Published: August 2024

Abstract
Subjectivists about practical normativity hold that an agent's favouring and disfavouring attitudes give rise to practical reasons. On this view, an agent's normative reason to choose vanilla over chocolate ice cream ultimately turns on facts about what appeals to her rather than facts about what her options are like attitude-independently. Objectivists—who ground reasons in the attitude-independent features of the things we aim at—owe us an explanation of why it is rational to choose what we favour, if not simply because favouring is a source of reasons. My aim in this paper is to supply such a story. The proposal is roughly that when an agent cannot base her choices on her judgements about what she has most reason to do, structural rationality extends to her a license to choose something simply because she favours it, without imbuing favouring with the authority of a normative reason.
Surviving and Resisting Retrenchment: US Resettlement Organizations’ Responses to Trump-era Anti-refugee Policy
Authors: Howsam Scholl Jess , Darrow Jessica H 
Published: August 2024

Abstract
Retrenchment and erosion of refugee protections have been on the rise in multiple contexts around the world. In the United States, the Trump Administration’s refugee policies threatened the very survival of domestic resettlement institutions. The administration reduced the number of refugees, cut funds, and sewed confusion. In the face of restrictionist policies, how did refugee advocates respond? Leveraging a case study of resettlement organisations’ responses to Trump-era anti-refugee policies, this article demonstrates that administrators not only adapted creatively to survive the barrage of attacks but also engaged in meaningful political contestation. In circumscribed moments, administrators defied theoretical expectations: they placed the collective above the individual and challenged exploitative dynamics fundamental to US refugee programmes. This article draws on critical theory to analyse administrative resistance, repositioning bureaucrats as advocates in the process. In doing so, the article makes three main contributions. First, it elucidates the unseen role of bureaucrats as agents of progressive institutional change. Next, it offers new analytic purchase into puzzling organisational behaviour by foregrounding social relations of power. Finally, the article provides tools and resources for resettlement organisations navigating retrenchment globally.
The yellowhorn MYB transcription factor MYB30 is required for wax accumulation and drought tolerance
Authors: Liu Xiaojuan , Ban Zhuo , Yang Yingying , Xu Huihui , Cui Yifan , Wang Chenxue , Bi Quanxin , Yu Haiyan , Wang Libing 
Published: August 2024

Abstract
Yellowhorn (Xanthoceras sorbifolium Bunge) is an economically important tree species in northern China, mainly distributed in arid and semi-arid areas where water resources are scarce. Drought affects its yield and the expansion of its suitable growth area. It was found that the wax content in yellowhorn leaves varied significantly among different germplasms, which had a strong correlation with the drought resistance of yellowhorn. In this study, XsMYB30 was isolated from ‘Zhongshi 4’ of yellowhorn, a new highly waxy variety. DAP-Seq technology revealed that the pathways associated with fatty acids were significantly enriched in the target genes of XsMYB30. Moreover, the results of electrophoretic mobility shift assay, yeast one hybrid assay and dual-luciferase assay demonstrated that XsMYB30 could directly and specifically bind with the promoters of genes involved in wax biosynthesis (XsFAR4, XsCER1 and XsKCS1), lipid transfer (XsLTPG1 and XsLTP1) and fatty acid synthesis (XsKASIII), thus enhancing their expression. In addition, the overexpression of XsMYB30 in poplar promoted the expression levels of these target genes and increased the wax deposition on poplar leaves leading to a notable improvement in the plant’s ability to withstand drought. These findings indicate that XsMYB30 is an important regulatory factor in cuticular wax biosynthesis and the drought resistance of yellowhorn.
Junta Democrática: Californios and Reconstruction in California
Authors: Suárez Camille 
Published: August 2024

Abstract
During the Civil War and Reconstruction Era, elite Californios—Mexicans of mixed-race descent made citizens by the Treaty of Guadalupe Hidalgo—supported legislation and political platforms that rejected the varied attempts at biracial democracy. Through an examination of the political life of Antonio Coronel, this article reconsiders elite Californios as state makers and obstructors of Reconstruction in California. At the end of the U.S.-Mexico War and until his death in 1894, Coronel, like other Californios, collaborated with Anglo American politicians to maintain his regional power by supporting a racially restrictive state. In offering their cooperation, elite Californios momentarily maintained their privileged social status in areas where Californios held local political control, such as Los Angeles and Santa Barbara. While Anglo American settlers relied on elite Californios for political legitimacy and state making, they viewed Californios as unassimilable into whiteness because of their Spanish culture and mixed ancestry, and they gradually denied Californio claims to racial superiority and socio-legal privileges, as political cooperation became less crucial to the success of the state project. As a direct result of Coronel’s and other elite Californios’ cooperation before the U.S. Civil War (1861–1865) and through Reconstruction (1863–1879), the California government rejected the federal government’s experiment in biracial democracy and supported policies of white supremacy that targeted the state’s growing non-white populations, a rejection that eventually jeopardized Californio power, including Coronel’s. This article demonstrates that Californio participation was crucial to the state’s rejection of Reconstruction.
Genome Sequence Data of Pseudalkalibacillus hwajinpoensis MABIK MI00000821, an Inhibitor of Fumonisin Production in Fusarium fujikuroi
Authors: Shin Soobin , Lee Jin Woo , Lee Nahyun , Han Jae Woo , Choi Gyung Ja , Son Hokyoung , Kim Hun 
Published: August 2024

Pseudalkalibacillus hwajinpoensis strain MABIK MI00000821 isolated from seawater exhibited inhibitory activity against the fumonisin production of Fusarium fujikuroi. Here, we report the draft genome sequence of the strain MABIK MI00000821 obtained using the PacBio RSII system. The genome comprises a single circular chromosome 4,369,347 bp in length, with an average GC content of 40.1%. Genome annotation predicted 4,351 protein-coding genes, 27 rRNA genes, and 89 tRNA genes. Moreover, the MABIK MI00000821 genome harbors five putative biosynthetic gene clusters responsible for secondary metabolites, including terpenes, a polyketide, and a siderophore. This genome sequence will contribute to a better understanding of the fumonisin inhibitory mechanism of the P. hwajinpoensis strain. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Intracellular TAS2Rs act as a gatekeeper for the excretion of harmful substances via ABCB1 in keratinocytes
Authors: Mori Sazanami , Nakamura Natsuki , Fuchigami Ayane , Yoshimoto Satoshi , Sakakibara Moe , Ozawa Toshiyuki , Aoki Junken , Inoue Asuka , Sumida Hayakazu , Ando Hideya , Nakamura Motonao 
Published: August 2024

AbstractBitter taste receptors (TAS2Rs) are not only expressed in the oral cavity but also in skin. Extraoral TAS2Rs are thought to be involved in non‐taste perception and tissue‐specific functions. Keratinocytes that express TAS2Rs in the skin provide a first‐line defense against external threats. However, the functional roles of these receptors in host defense remain unclear. Here, we demonstrated the sensory role of intracellularly located TAS2Rs against toxic substances in keratinocytes. Although many G protein‐coupled receptors elicit signals from the surface, TAS2Rs were found to localize intracellularly, possibly to the ER, in human keratinocytes and HaCaT cells. TAS2R38, one of the TAS2R members, activated the Gα12/13/RhoA/ROCK/p38 MAP kinase/NF‐κB pathway upon stimulation by phenylthiocarbamide (PTC), an agonist for this receptor, leading to the production of ABC transporters, such as ABCB1, in these cells. Notably, treatment with bitter compounds, such as PTC and saccharin, induced the upregulation of ABCB1 in HaCaT cells. Mechanistically, intracellular TAS2R38 and its downstream signaling Gα12/13/RhoA/ROCK/p38 MAP kinase/NF‐κB pathway were identified to be responsible for the above effect. Pretreatment with PTC prevented the accumulation of rhodamine 123 because of its excretion via ABCB1. Furthermore, pretreatment with PTC or saccharin counteracted the effect of the toxic compound, diphenhydramine, and pretreated HaCaT cells were found to proliferate faster than untreated cells. This anti‐toxic effect was suppressed by treatment with verapamil, an ABCB1 inhibitor, indicating that enhanced ABCB1 helps clear toxic substances. Altogether, harmless activators of TAS2Rs may be promising drugs that enhance the excretion of toxic substances from the human skin.
Neurocognitive changes in a patient receiving esketamine for treatment-resistant depression
Authors: Kundert Carolyn F. , Sobule Robert M. , Ithman Muaid 
Published: August 2024

ABSTRACT
Esketamine, the s(+) enantiomer of ketamine, was approved in 2019 as the first rapid-acting intranasal spray medication for treatment-resistant depression; the drug is given in combination with an antidepressant. The treatment is self-administered in a clinical setting under the supervision of a healthcare provider and usually is well tolerated. Many of its adverse reactions are mild, temporary, and dose-dependent, and they improve with subsequent treatments. Although the prescribing information lists difficulty remembering or thinking as possible adverse reactions, a neurocognitive evaluation is not part of the initial patient evaluation. This case report focuses on a patient whose neurocognitive symptoms worsened with esketamine treatment, necessitating treatment discontinuation.
Understanding the gastrointestinal microbiome in systemic sclerosis: methodological advancements and emerging research
Authors: Haussmann Alana J. , McMahan Zsuzsanna H. , Volkmann Elizabeth R. 
Published: August 2024

Purpose of review
This review highlights the role of the gastrointestinal (GI) microbiome in systemic sclerosis (SSc). We describe techniques for evaluating the GI microbiome in humans, and emerging research linking GI microbiome alterations (i.e., dysbiosis) and distinct SSc clinical manifestations. We also address the evolving treatment landscape targeting dysbiosis in SSc.

Recent findings
Recent literature brings into focus the complex relationship between the GI microbiome and SSc pathogenesis. Advanced techniques (e.g., shotgun metagenomics, meta-transcriptomics) provide deeper insights into microbial taxonomy and active gene expression, exposing dysbiosis as a potential driver of SSc. New studies demonstrate that SSc patients who possess specific SSc clinical features, (e.g., interstitial lung disease), have unique GI microbiome profiles.

Summary
Dysbiosis is associated with specific clinical features in patients with SSc. New tools for studying the GI microbiome have furthered our understanding of the relationship between dysbiosis and SSc complications. Therapeutic avenues such as dietary adjustments, probiotics, antibiotics, mindfulness practices, and fecal transplants offer potential for managing SSc and preventing its progression through GI microbiome modulation. By clarifying what is known about the relationship between the GI dysbiosis, GI dysfunction, and SSc, this review enhances our understanding of SSc pathogenesis and proposes targeted interventions.
Interprofessional Education Opportunities for Health Care Educators in the Practice Setting: An Integrative Review
Authors: Dolan Sara , Nowell Lorelli 
Published: August 2024

Introduction:
Health care educators in the practice setting are responsible for providing education to frontline staff and require knowledge and skills to interact with interprofessional health care providers and teach content in an effective way. Interprofessional education opportunities for health care educators in the practice setting may be helpful in preparing educators to meet the needs of frontline staff, yet the extant state of literature on this topic has not been recently synthesized. In this integrative review, we aimed to explore what is known about interprofessional education opportunities offered to health care educators who are responsible for educating other health care professionals in practice settings and assess how these education opportunities were described and evaluated in the literature.

Methods:
We conducted an integrative literature review following the methodology put forth by Toronto and Remington.

Results:
Of the 3690 publications identified, 30 met our inclusion criteria. Overall, the publications lacked rigorous methodology. Education interventions varied in content, duration, and teaching strategies. Key findings were identified: (1) educator satisfaction and content relevance, (2) impact on knowledge, skills, and confidence, (3) impact on teaching practice, (4) impact on clinical practice, (5) impact on interprofessional competencies and attitudes, (6) challenges to implementing interprofessional education opportunities, and (7) facilitators to implementing interprofessional education opportunities.

Discussion:
Although interprofessional education opportunities for health care educators in the practice setting may be beneficial to educators and the frontline staff they serve, more rigorous research is needed to understand how these opportunities can influence teaching and clinical practice.
The Impact of Femtosecond Laser on Intraocular Pressure With Cataract Surgery in Healthy Eyes
Authors: Mathalone Nurit , Ben-Shaul Or , Podkovyrin Olga , Lux Chen , Geyer Orna 
Published: August 2024

Précis:
Femtosecond laser-assisted cataract surgery (FLACS) leads to an increase in intraocular pressure (IOP) during the procedure and subsequent IOP reduction after surgery, with greater magnitude in eyes with higher preoperative IOP.

Purpose:
To evaluate the effect of FLACS using the LDVZ8 laser on IOP during and after surgery, and to compare the IOP-lowering effect of FLACS and conventional phacoemulsification cataract surgery (CPCS).

Patients and Methods:
This prospective cohort study enrolled 395 healthy eyes (395 patients) scheduled for FLACS (n=245) and CPCS (n=150). FLACS was performed using the LDVZ8 laser. During FLACS, IOP was assessed before and immediately after docking. IOP reduction during a 6-month postoperative period was evaluated following FLACS and CPCS. Multivariate analyses were performed.

Results:
The mean IOP increase after docking was 2.3±4.1 mm Hg (P<0.0001); the maximum increase was 17.6 mm Hg, peak of 38 mm Hg. Sixty-one eyes (25.1%) demonstrated an increase of ≥5 mm Hg and 10 (3.7%) showed an increase of ≥10 mm Hg; predocking IOP was associated with an IOP increase of ≥5 mm Hg (P=0.029). IOP reduction over 6 months postsurgery was similar for FLACS and CPCS (P>0.05), −1.33±3.12 mm Hg for FLACS (P<0.001) and −1.4±2.87 mm Hg for CPCS (P<0.001). Preoperative IOP correlated statistically significantly with IOP reduction in both FLACS (β −0.742, P<0.001) and CPCS (β −0.743, P<0.001).

Conclusions:
Although the LDVZ8 laser procedure causes an increase in IOP in some healthy eyes, a subsequent decrease in IOP is observed after FLACS. The IOP-lowering effect of FLACS is similar to CPCS and tends to be more pronounced in eyes with higher preoperative IOP. Eyes with higher preoperative IOP are prone to IOP elevation during FLACS, a critical consideration for glaucoma patients.
An urgent invasion: lower mandible Ewing’s sarcoma and unleashed massive abscess – a case report study
Authors: Faraji Navid , Goli Rasoul , Bahrami Soheyla , Shaddeli Sevda 
Published: August 2024

Introduction and importance:
Ewing’s sarcoma (ES) is a rare and aggressive bone tumor that can affect any bone but is particularly rare when it involves the mandible. Mandible ES often presents with nonspecific symptoms and requires a multimodal approach to treatment.

Case presentation:
This case involves a 19-year-old woman who had ES of the mandible. At the initial stage, she stated that she was bothered by a small round mass that caused her discomfort during chewing. The first examination by a specialist required a more detailed examination by biopsy, which the immunohistochemistry results confirmed the diagnosis of ES based on this detailed information.

Clinical discussion:
Mandible ES is a rare and aggressive bone tumor that requires early diagnosis and prompt multimodal management to achieve good outcomes. Despite being a challenging diagnosis, histologic evaluation and molecular testing have revolutionized the diagnosis and management of these tumors in recent years.

Conclusion:
By the way of conclusion, recognizing the importance of early diagnosis and aggressive multimodal management, clinicians and researchers should continue to work collaboratively to improve the management of mandible ES and enhance outcomes for affected patients.
A systematic review and meta-analysis of hip preservation osteotomy in osteonecrosis of femoral head
Authors: Triangga Aditya F.R. , Magetsari Rahadyan , Muhammad Hilmi , Putra Satria P. , Fazatamma Dandy A. , Saraswati Paramita A. , Huwaidi A. Faiz 
Published: August 2024

Background:
Osteonecrosis of the femoral head occurs when there is insufficient vascularization of the femoral head, leading to bone cell death and potential bone collapse. Osteotomy is a hip preservation procedure often reserved for young patients. Necrotic lesion size and site are believed to be crucial factors in predicting the outcome of the procedure.

Methods:
The authors performed this systematic review in line with the Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 statement. The review protocol had been registered on PROSPERO. A literature search was performed using electronic databases including studies published within the past 10 years. As our objective was to examine the correlation between preoperative necrotic size and osteotomy outcome, the authors focused on patients with early-stage osteonecrosis of the femoral head who underwent rotational or angular preservation osteotomy. The Newcastle–Ottawa Quality Assessment Scale was utilized to assess the included studies’ quality.

Results:
Of the 1217 articles initially identified, 18 met the inclusion criteria. Pooled data of 78 hips showed favorable outcomes in Kerboul Angle <200o group with an OR 0.06 (95% CI: 0.01–0.39). Meanwhile, pooled 276 hips were assessed using the JIC type yielded in an OR 0.55 (95% CI: 0.10–2.9), which showed better outcomes for hips with JIC types A, B, and C1.

Conclusion:
A consensus on eligibility based on necrosis quantification has not been reached when choosing an osteotomy procedure. The ability to predict osteotomy outcomes in patients diagnosed with JIC type A-C1 and a Kerboul angle <200° remains uncertain. It is important to note that prior recommendations to perform osteotomy based on these parameters may still hold relevance attributable to the low importance of the statistical data obtained.
Impaired pain in mice lacking first-order posterior medial thalamic neurons
Authors: Sgourdou Paraskevi , Schaffler Melanie , Choi Kyuhyun , McCall Nora M. , Burdge Justin , Williams Joelle , Corder Gregory , Fuccillo Marc V. , Abdus-Saboor Ishmail , Epstein Douglas J. 
Published: August 2024

Abstract
The thalamus plays an important role in sensory and motor information processing by mediating communication between the periphery and the cerebral cortex. Alterations in thalamic development have profound consequences on sensory and motor function. In this study, we investigated a mouse model in which thalamic nuclei formation is disrupted because of the absence of Sonic hedgehog (Shh) expression from 2 key signaling centers that are required for embryonic forebrain development. The resulting defects observed in distinct thalamic sensory nuclei in Shh mutant embryos persisted into adulthood prompting us to examine their effect on behavioral responses to somatosensory stimulation. Our findings reveal a role for first-order posterior medial thalamic neurons and their projections to layer 4 of the secondary somatosensory cortex in the transmission of nociceptive information. Together, these results establish a connection between a neurodevelopmental lesion in the thalamus and a modality-specific disruption in pain perception.
Clinical Applications of Artificial Intelligence in Occupational Health
Authors: Chaudhry Zaira S. , Choudhury Avishek 
Published: August 2024

Objectives
The aims of the study are to identify and to critically analyze studies using artificial intelligence (AI) in occupational health.

Methods
A systematic search of PubMed, IEEE Xplore, and Web of Science was conducted to identify relevant articles published in English between January 2014–January 2024. Quality was assessed with the validated APPRAISE-AI tool.

Results
The 27 included articles were categorized as follows: health risk assessment (n = 17), return to work and disability duration (n = 5), injury severity (n = 3), and injury management (n = 2). Forty-seven AI algorithms were utilized, with artificial neural networks, support vector machines, and random forest being most common. Model accuracy ranged from 0.60–0.99 and area under the curve (AUC) from 0.7–1.0. Most studies (n = 15) were of moderate quality.

Conclusions
While AI has potential clinical utility in occupational health, explainable models that are rigorously validated in real-world settings are warranted.
The Impact of Inflammatory Bowel Diseases on Patients' Quality of Life and Work Functionality
Authors: Leso Veruscka , Testa Anna , Pacella Daniela , Macrini Maria Carmela , Villani Guido Daniele , Gervetti Paola , Barbato Giuseppe , Rispo Antonio , Castiglione Fabiana , Iavicoli Ivo 
Published: August 2024

Background
This study aimed to assess the employment status, quality of life, and work functionality in patients affected by inflammatory bowel diseases (IBDs).

Methods
Patients (N = 216) were enrolled between June 2020 and October 2021. Personal, clinical, and occupational features were investigated. The Short Inflammatory Bowel Disease Questionnaire and the Work Productivity and Activity Impairment questionnaire were administered.

Results
Among the enrolled patients, 114 (53%) were employed. The mean absenteeism and presenteeism percentages of 10% and 37% were determined, with 44% and 39% of daily and work activity impairment, respectively. A poor Health-Related Quality of Life (HRQoL) was retrieved (47 ± 12). Extraintestinal manifestations, disease activity, and HRQoL were associated with occupational outcomes.

Conclusions
IBD can impact patients' work functionality. The association between clinical, psychological, and occupational issues suggests the relevance for a multidisciplinary management of the disease.