bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of magnesia additive on the morphology and physico‐mechanical properties of kaolinitic clays ceramics
Authors: Nurudeen Abdulhakeem , Dagwa Ishaya , Ugheoke Benjamin , Muhammad Ibrahim , Arogundade Adiat 
Published: August 2024

AbstractNigeria is rich in various minerals, including crude oil and solid minerals. However, despite this abundance, effectively utilizing these resources remains a challenge. Kaolin, also known as white China clay, is a crucial raw material used in industries such as ceramics, paper, paint, plastic, and welding electrodes. Despite its plentiful availability in Nigeria, kaolin has not been adequately exploited. Consequently, Nigeria spends approximately 14.35 million USD annually to import refined kaolin to meet local demand, due to the lack of capacity to process it to the required industrial standards. This study investigates the effect of magnesia (MgO) on the morphology and physico‐mechanical properties of kaolinitic clay ceramics using the slip‐casting method. Various analytical techniques were employed to examine the kaolin, including X‐ray fluorescence (XRF), X‐ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM). Also, compressive and flexural tests were conducted. The XRF analysis revealed that all samples contained SiO2 (54.41%wt), Al2O3 (34.05%wt), and other trace elements. The main mineral phases identified were quartz, microcline, and orthoclase. Among the samples, 30–200 exhibited the highest compressive strength at 218 MPa, while the highest flexural rigidity was observed in sample 15–200. The results indicated that MgO significantly affected the properties of kaolin, as the control sample had a compressive strength of 59 MPa. The study also found that the quantities of additives should align with stoichiometric requirements. Results showed hypo‐stoichiometry in samples 30–600 and 15–400, and hyper‐stoichiometry in sample 60–200. XRF, XRD, and FTIR spectra confirmed the elemental and chemical compositions of the samples, while SEM analysis revealed the morphological structure. It was observed that increasing the magnesia content from 10% to 30% led to an increase in pore spaces within the samples. TGA analysis provided insights into the relationship between mass loss and temperature variation in the ceramic samples, While The DTG curves explain the endothermic phase changes over changes in temperature; at 50–150°C, loss of the water phase is complete, at 300–400°C burning of organic matter phase is achieved and at 500–700°C endothermic dihyroxylation phase begins forming armorphous meta‐kaolin.
A real‐time working memory evaluation system for macaques in microwave fields
Authors: Li Bowen , Zhang Xueyan , Qiao Nan , Chen Jiawei , Bi Weijie , Zhi Weijia , Ma Lizhen , Miao Congcong , Wang Lifeng , Zou Yong , Hu Xiangjun 
Published: August 2024

AbstractWith the development and widespread application of electromagnetic technology, the health hazards of electromagnetic radiation have attracted much attention and concern. The effect of electromagnetic radiation on the nervous system, especially on learning, memory, and cognitive functions, is an important research topic in the field of electromagnetic biological effects. Most previous studies were conducted with rodents, which are relatively mature. As research has progressed, studies using non‐human primates as experimental subjects have been carried out. Compared to rodents, non‐human primates such as macaques not only have brain structures more similar to those of humans but also exhibit learning and memory processes that are similar. In this paper, we present a behavioral test system for the real‐time evaluation of the working memory (WM) of macaques in a microwave environment. The system consists of two parts: hardware and software. The hardware consists of four modules: the operation terminal, the control terminal, the optical signal transmission, and detection module and the reward feedback module. The software program can implement the feeding learning task, the button‐pressing learning task, and the delayed match‐to‐sample task. The device is useful for the real‐time evaluation of the WM of macaques in microwave environments, showing good electromagnetic compatibility, a simple and reliable structure, and easy operation.
A sensitive benzothiazole fluorescent probe for the detection of γ‐glutamyl transpeptidase activity and its application
Authors: Wu Xiaoming , Ding Leyuan , Yang Shaoxiang , Tian Hongyu , Sun Baoguo 
Published: August 2024

AbstractA sensitive benzothiazole fluorescent probe (PBZO) for the detection of γ‐glutamyl transpeptidase (GGT) activity was developed. Based on the enzymatic hydrolysis of peptide bonds by glutamyl transpeptidase, it can be specifically recognized by PBZO. The PBZO has a good linear relationship with different gradients of GGT activity at the emission wavelength of 560 nm, the Stokes shift reached 215 nm, and the detection limit of GGT activity is 0.1644 U/ml. With the increase of GGT concentration in the probe solution, the color of the solution gradually changed from orange to dark yellow under the 365 nm UV lamp. The same color change was also observed on the probe test paper. In addition, there is a linear relationship between the GGT activity and the R‐value of the probe solution. More importantly, the probe has a good recovery rate in serum. Therefore, this probe can be used as a convenient tool for detecting GGT activity.
Comparing five‐factor personality traits and psychological distress between dysphonic patients and individuals with vocally healthy voices
Authors: Aghajanzadeh Mahshid , Dabirmoghaddam Payman , Soleimani Mehdi , Saeedi Saeed 
Published: August 2024

AbstractIntroductionIt was reported that voice can carry information about personality and psychological distress. In the current study, the relationship between five‐factor personality traits and psychological distress with voice was enlightened from diverse aspects.MethodsA total of 119 participants (55 with and 64 without dysphonia) sustained vowels /a/ and /i/, read six standard sentences, and answered a question. Three raters auditory–perceptually evaluated the vocal samples using the Persian version of CAPE‐V. The participants were distributed into four groups (vocally healthy, mild, moderate, and severe dysphonia). They completed two questionnaires: NEO Five‐Factor Inventory (NEO‐FFI) and Depression, Anxiety, and Stress Scale‐21.ResultsResults showed that the conscientiousness (U = 1146.500, z = −3.27, p = .001) in the dysphonia group was significantly less than the vocally healthy group. Depression (U = 1381.000, z = −2.03, p = .042) and anxiety (U = 1181.000, z = −3.10, p = .002) in the dysphonia group were significantly higher than in the vocally healthy group. In comparing different abnormal overall voice qualities, the mild dysphonia group revealed significantly lower conscientiousness (p = .001) and significantly higher anxiety (p = .002) relative to the vocally healthy group.ConclusionsFindings indicated that the conscientiousness trait could play an influential role in persons with dysphonia and its psychological status. The voice care team should consider conscientiousness and psychological distress during the assessment and treatment of dysphonic patients.
Integrating sustainability with performance: Effect of social and environmental dimensions of the balanced scorecard on the performance of financial institutions in Ethiopia, moderated by management commitment
Authors: Ayele Nathenael Fentaw , Singh Manjit 
Published: August 2024

AbstractThis study investigates the primary factors driving sustainable performance in financial institutions, focusing on the effect of social and environmental aspects of a balanced scorecard on the performance of financial institutions in Ethiopia. It also examines how management commitment moderates the relationship between these social and environmental dimensions and institutional performance. The research adopts a descriptive and explanatory design, utilizing proportional stratified sampling followed by systematic random sampling. From a population of 4990, a sample of 480 was determined using Daniel Soper's formula for structural equation modeling, accounting for an expected effect size of 0.23, a statistical power level of 0.95, and a probability level of .05. Data analysis involved descriptive statistics, covariance‐based structural equation modeling, and the interaction‐term method for moderation. Findings indicate a significant positive relationship between the social and environmental dimensions of the balanced scorecard and the performance of Ethiopian financial institutions. Additionally, management commitment significantly enhances this relationship. The study confirms that incorporating social and environmental metrics into the balanced scorecard positively impacts financial institution performance, emphasizing the importance of sustainability in performance measurement frameworks. This research underscores the practical implications of integrating sustainability metrics and management commitment in enhancing institutional performance.
Structure‐based pharmacophore modeling for precision inhibition of mutant ESR2 in breast cancer: A systematic computational approach
Authors: Islam Sirajul , Amin Md. Al , Rengasamy Kannan R.R. , Mohiuddin A. K. M. , Mahmud Shahin 
Published: August 2024

AbstractBackgroundBreast cancer, a leading cause of female mortality, is closely linked to mutations in estrogen receptor beta (ESR2), particularly in the ligand‐binding domain, which contributed to altered signaling pathways and uncontrolled cell growth.Objectives/AimsThis study investigates the molecular and structural aspects of ESR2 mutant proteins to identify shared pharmacophoric regions of ESR2 mutant proteins and potential therapeutic targets aligned within the pharmacophore model.MethodsThis study was initiated by establishing a common pharmacophore model among three mutant ESR2 proteins (PDB ID: 2FSZ, 7XVZ, and 7XWR). The generated shared feature pharmacophore (SFP) includes four primary binding interactions: Hydrogen bond donors (HBD), hydrogen bond acceptors (HBA), hydrophobic interactions (HPho), and Aromatic interactions (Ar), along with halogen bond donors (XBD) and totalling 11 features (HBD: 2, HBA: 3, HPho: 3, Ar: 2, XBD: 1). By employing an in‐house Python script, these 11 features distributed into 336 combinations, which were used as query to isolate a drug library of 41,248 compounds and subjected to virtual screening through the generated SFP.ResultsThe virtual screening demonstrated 33 hits showing potential pharmacophoric fit scores and low RMSD value. The top four compounds: ZINC94272748, ZINC79046938, ZINC05925939, and ZINC59928516 showed a fit score of more than 86% and satisfied the Lipinski rule of five. These four compounds and a control underwent molecular (XP Glide mode) docking analysis against wild‐type ESR2 protein (PDB ID: 1QKM), resulting in binding affinity of −8.26, −5.73, −10.80, and −8.42 kcal/mol, respectively, along with the control −7.2 kcal/mol. Furthermore, the stability of the selected candidates was determined through molecular dynamics (MD) simulations of 200 ns and MM‐GBSA analysis.ConclusionBased on MD simulations and MM‐GBSA analysis, our study identified ZINC05925939 as a promising ESR2 inhibitor among the top four hits. However, it is essential to conduct further wet lab evaluation to assess its efficacy.
Chronic inflammatory demyelinating polyneuropathy. A case description
Authors: Ariana Garcia‐Castillo María 
Published: August 2024

Key Clinical MessagePatients affected by chronic inflammatory demyelinating polyradiculoneuropathy require close follow up due to the neuronal demyelination along with axonal degeneration associated with the disease process, giving the opportunity to the medical team of adequating therapeutics and other medical interventions, according to the evolution of the symptoms, to prevent irreversible axonal degeneration.
Complete percutaneous coronary revascularization: An elegant solution to left ventricular dysfunction caused by severe coronary artery disease
Authors: Milutinovic Stefan , Singh Kamaldeep , Oluic Stevan , Lopez‐Mattei Juan C. , Escárcega Ricardo O. 
Published: August 2024

Key Clinical MessageWith increased complexity in both medical comorbidities and coronary anatomy, the proportion of surgically turndown patients and high‐risk PCI will continue to rise. Impella‐assisted complex PCI can be performed with high technical success and can improve quality of life, angina score, and potentially left ventricular ejection fraction.
Primary hyperaldosteronism associated with type 3 autoimmune polyendocrine syndrome: A rare case report
Authors: Li Xuesong , Gu Liangbiao , Zhao Wenhui , Xiao Jianzhong , Cao Chenxiang 
Published: August 2024

Key Clinical MessagePrimary hyperaldosteronism with type 3 autoimmune polyendocrine syndrome was a rare combination of both hyper‐ and hypoendocrine gland function. Comprehensive treatment including surgery and replacement therapy might be an effective strategy.AbstractPrimary aldosteronism (PA) is a common cause of secondary hypertension originating from hormones. Type 3 autoimmune polyendocrine syndrome (APS‐3) is characterized by the simultaneous or subsequent occurrence of autoimmune‐mediated endocrine gland damage, except for Addison disease. Here we reported an extremely rare case of a 63‐year‐old woman with PA and APS‐3 who initially presented with hypertension (HT). The APS‐3 of this patient mainly exhibited type 1 diabetes mellitus (T1DM) and Hashimoto's thyroiditis. She underwent the adrenal adenoma resection with a histopathologic diagnosis of adrenal cortical adenoma. After surgery, the HT of this patient was immediately reversed, and the concentration of serum potassium went back to normal. Then, this patient was administered with replacement therapy of insulin and levothyroxine sodium tablets (L‐T4).
A Novel One‐Class Convolutional Autoencoder Combined With Excitation–Emission Matrix Fluorescence Spectroscopy for Authenticity Identification of Food
Authors: Yan Xiaoqin , Jia Baoshuo , Long Wanjun , Huang Kun , Wang Tong , Wu Hailong , Yu Ruqin 
Published: August 2024

ABSTRACTIn this work, a novel one‐class classification algorithm one‐class convolutional autoencoder (OC‐CAE) was proposed for the detection of abnormal samples in the excitation–emission matrix (EEM) fluorescence spectra dataset. The OC‐CAE used Boxplot to analyze the reconstruction errors and used the LOF algorithm to handle features extracted by the hidden layer in the convolutional autoencoder (CAE). The fused information provides the basis for more accurate pattern recognition, ensures flexibility in model training, and can obtain higher model specificity, which is important in the field of food quality control. To demonstrate the reliability and advantages of OC‐CAE, two EEM cases related to the authentication of food including the Zhenjiang aromatic vinegar (ZAV) case and the camellia oil (CAO) case were studied. The results showed that OC‐CAE identified all abnormal samples in the two cases, reflecting excellent performance in the detection of abnormal samples, and that it, coupled with EEM, would be an effective tool for the authenticity identification of food.
Boosting the Efficiency of Red Thermally Activated Delayed Fluorescence via Conjugation Enhancement in Push‐Pull Naphthalimide Derivatives
Authors: Montanari Chiara , Ji Tiwari Nikhil , Misra Rajneesh , Carlotti Benedetta 
Published: August 2024

AbstractIn this work, we synthesize a series of push–pull compounds bearing naphthalimide as the electron acceptor and tetraphenylethylene (TPE)/triphenylamine (TPA)/phenothiazine (PTZ) as the electron rich/electron donor units. These moieties are arranged in highly conjugated quadrupolar structures. The structure–property relationships are investigated through a joint experimental time–resolved spectroscopic and computational TD–DFT study. The femtosecond transient absorption and fluorescence up–conversion experiments reveal ultrafast photoinduced intramolecular charge transfer. This is likely the key factor leading to efficient spin–orbit CT–induced intersystem crossing for the TPA– and PTZ–derivatives as well as to small singlet–to–triplet energy gap. Consequently, evidence for a delayed fluorescence component is found together with the main prompt emission in the fluorescence kinetics both in solution and in thin film. The weight of the Thermally Activated Delayed Fluorescence (TADF) is greatly enhanced when these fluorophores are used as guests in solid–state host matrices. TADF is interestingly revealed in the orange–red region of the visible. Such long wavelength emission is here observed with surprisingly large fluorescence quantum yields, thanks to the conjugation enhancement achieved in these newly synthesized structures relative to previous studies. Our findings may be thus promising for the future development of efficient third generation TADF–based OLEDs.
First Principles Simulations of Optical Rotation of Chiral Molecular Crystals
Authors: Forson Emmanuel , Parsons Taylor , Caricato Marco 
Published: August 2024

ABSTRACTIn this work, we present simulations of the optical rotation (OR) for five molecular crystals at density functional theory level with periodic boundary conditions (DFT‐PBC). Calculations are compared with experimental measurements and show semi‐quantitative agreement with experimental data for three of the crystals: tartatic acid, benzil, and pentaerythritol. For the other two crystals, aspartic acid and glutamic acid, the calculated data are in qualitative agreement with, but two orders of magnitude smaller than, the experimental data. We provide some arguments that support the theoretical predictions and suggest that the experiments should be revisited. We also find that the position of H centers provided in experimental X‐ray data is not sufficiently reliable for simulating OR, and better results are obtained when H atoms are allowed to relax while keeping heavier elements fixed at the experimental positions. Comparison with molecular cluster calculations with a better functional and a larger basis set indicate that the role of intermolecular interactions (reproduced with the PBC technique) is as or more important than the choice of model chemistry. Despite the current limitations in the level of theory that can be employed, these simulations provide a promising avenue to investigate the effect of intermolecular interactions on this sensitive electronic property of molecules and materials.
Unexpected stability in faunal population abundances following an estuary‐wide collapse of oysters
Authors: Love Gabrielle D. , Siders Zachary A. , Gandy David A. , Pine William E. , Baker Shirley , Camp Edward V. 
Published: August 2024

AbstractLive oyster reefs are considered a critical recruitment habitat for estuarine faunal populations as localized in situ or mesocosm studies have demonstrated many faunal species prefer live oyster habitat. It has therefore been assumed that the loss of live oyster habitat would precipitate faunal population declines, but this has been largely untested at large (estuary) scales. Here, we assessed how estuary‐wide faunal populations were affected by a 95% loss of live oyster habitat following the 2012 oyster collapse of Apalachicola Bay, FL, which previously supported one of the largest oyster fisheries in the United States. We standardized long‐term fisheries‐independent monitoring seine and trawl data to create relative indices of resident, associated, and transient faunal species' overall abundance and recruit abundance (restrictive to sizes between 15% and 35% of ). We expected that both relative abundance indices would decrease following the oyster collapse, particularly among species that reside on or recruit to oyster reefs. However, analyses via a series of one‐sided Bayesian t tests did not indicate that faunal recruitment or overall abundance significantly declined in 2012 post‐collapse. As the response of the faunal population could be lagged relative to the 2012 collapse, we also conducted change point analyses to search for lagged declines. Of the 24 relative abundance time series, only two had significant change points post‐collapse, and only black sea bass overall relative abundance declined with an associated change point at the end of the time series. The surprising paucity of faunal decline following oyster loss may be due to the use of alternative habitat types, exceptionally lagged faunal responses, or, perhaps most compelling, a disconnect between preferred and required habitats. Our failure to detect faunal consequences following an oyster population collapse suggests that assumptions of habitat loss (or restoration) effects on estuarine fauna at ecosystem scales are not straightforward and the extrapolation of sub‐estuary‐scale studies may result in poor predictions of future outcomes.
The complement model disease paroxysmal nocturnal hemoglobinuria
Authors: Schmidt Christoph Q. , Höchsmann Britta , Schrezenmeier Hubert 
Published: August 2024

AbstractWe describe initial, current, and future aspects of complement activation and inhibition in the rare hematological disease paroxysmal nocturnal hemoglobinuria (PNH). PNH is a rare but severe hematological disorder characterized by complement‐mediated intravascular hemolysis resulting in anemia and severe thrombosis. Insights into the complement‐mediated pathophysiology ultimately led to regulatory approval of the first‐in‐class complement inhibitor, eculizumab, in 2007. This anti‐complement C5 therapy resulted in the stabilization of many hematologic parameters and dramatically reduced the often fatal, coagulant‐resistant thrombotic events. Despite the remarkable clinical success, a substantial proportion of PNH patients experience suboptimal clinical responses during anti‐C5 therapy. We describe the identification and mechanistic dissection of four unexpected processes responsible for such suboptimal clinical responses: (1) pharmacokinetic and (2) pharmacodynamic intravascular breakthrough hemolysis, (3) continuing low‐level residual intravascular hemolysis, and (4) extravascular hemolysis. Novel complement therapeutics mainly targeting different complement proteins proximal in the cascade attempt to address these remaining problems. With five approved complement inhibitors in the clinic and many more being evaluated in clinical trials, PNH remains one of the complement diseases with the highest intensity of clinical research. Mechanistically unexpected breakthrough events occur not only with C5 inhibitors but also with proximal pathway inhibitors, which require further mechanistic elaboration.