bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution au maintien du caractère opérationnel des plans d’intervention sanitaire d’urgence en santé animale
Authors: Puzin Lorraine , Villaggi Yann 
Published: November 2015

Preserving the operability of contingency plans for animal health emergencies.
Certain animal disease outbreaks require a quick and well managed response. They are emergencies, since any delay could result in huge economic losses. The French zoosanitary emergencies and crisis’ management mainly involves State Veterinary Services at local level. Contingency planning enables to organize the surveillance and eventually the response to outbreaks. The last decades have seen zoosanitary contingency plans adopt an inclusive, interdisciplinary approach, fostering flexibility and engagement of various stakeholders. Seven critical issues for their operability require specific vigilance by competent authorities : financial aspects, early-warning networks, human resources, material resources, communication, documentation of procedures, and of course continuous improvement. This article is an overview of the preparing work within the French Veterinary Services, stemming from the 2012 author’s thesis.
Les particularités de la reproduction de Varroa destructor, agent de la varroose de l’abeille domestique. perspectives de lutte
Authors: Wendling Sébastien 
Published: November 2015

Reproductive features of varroa destructor, agent of honeybee varroosis. Prospects for control.
More than 30 years after its first arrival, Varroa destructor, agent of honeybee varroosis, remains one of the most serious threat of french apiculture. Currently, the available means of control shows their limits. Further researches must be conduct to develop a sustainable parasitism control. During it reproductive phase, the parasite is particularly thrifty and closely linked to the cycle of its host. This weakness might be a promising line of approach.
Le guide Phénix
Authors: Béata Claude , Becquey Augustin , Boureau Vincent , Jançon Ghislaine , Mège Catherine , Rousselot Jean-François 
Published: November 2015

The phenix guide to animal euthanasia.
Euthanasia of animals is a veterinary act whose difficulty is evident at many levels : it generates sadness, if not distress, in the owner ; it ruins all hopes of a possible cure for the veterinarian ; its practical realization is never easy and requires a great level of professionalism from the practitioner. The "Phenix" site was conceived by Qualityvet to help veterinary practitioners. Thanks to an interactive information that includes both reglementary and technical advice, together with a few interesting returns from the field, the "Phenix" guide targets every animal species, whether pet animals or rent animals. For each animal species, it takes into consideration its pecularities during the three successive phases : before-during-and after euthanasia. Its clear presentation allows the practitioner to rapidly access the informatioon he is looking for.
Le microbe, l’insecte, l’homme et les autres... : le monde des maladies à vecteurs
Authors: Rodhain François 
Published: November 2015

The microbe, the insect, man and others… : the world of vector-borne diseases.
The transmission of pathogens by vector arthropods is an original, complex and efficient mean of propagation ; so, the sanitary and economic impact of such diseases appears considerable. Malaria is always a major endemic disease and other parasitic infections like leishmanioses, trypanosomoses or filarioses remain very prevalent in tropical countries. The incidence of Lyme borreliosis seems increasing and arboviral diseases like dengue, Chikungunya infection, Rift Valley fever, blue tongue and others are important concerns for those who are in charge of human or animal public health. Furthermore, the constant evolution of epidemiologic situations following ecologic changes often resulting of human activities is complicating the work of epidemiologists. We poorly understand the complexity of vectorial systems where arthropods can play many roles as they can be involved as vectors, reservoirs or disseminators and because their organism is a privileged site for the evolution of microorganisms. Facing the threat of vector-borne diseases, an efficient ecosanitary prevention is essential and this necessitates to carry on researches in several directions. In particular, we must study thoroughly the relationships between microorganisms and vectors, the ecology of arthropods, epidemiologic surveillance and vector control. That implies to have at our disposal well trained entomologists.
Diversité génétique d’Anaplasma Phagocytophilum, agent de l’anaplasmose granulocytaire, conséquences épidemiologiques et implications pour le contrôle en France
Authors: Chastagner Amélie Pierrette , Dugat Thibaud , Vourc’h Gwenaëlle , Chabanne Luc , Maillard Renaud , Boulouis Henri-Jean , Haddad Nadia , Leblond Agnès 
Published: November 2015

Genetic diversity of anaplasma phagocytophilum,
the causative agent of granulocytic anaplasmosis, implications for epidemiology and control in France.
Anaplasma phagocytophilum is a tick-borne bacterium and the etiologic agent of granulocytic anaplasmosis, an emerging disease that affects a wide range of mammals. In this paper, we present the recent knowledge gained from studies on the genetic diversity of this pathogen in France.
Multilocus sequence analysis (MLSA) was used to characterize the genetic diversity of A. phagocytophilum in populations of French cattle, horses, dogs, and roe deer. MLSA was based on nine loci (ankA, msp4, groESL, typA, pled, gyrA, recG, polA, and an intergenic region). Phylogenic analysis revealed three genetic clusters of bacterial variants in domesticated animals. The two principal clusters included 98% of the bacterial genotypes found in cattle, which were only distantly related to those in roe deer. One cluster comprised only cattle genotypes, while the second contained genotypes from cattle, horses, and dogs. The third contained all roe deer genotypes and three cattle genotypes. These results suggest that roe deer do not contribute to the spread of A. phagocytophilum in cattle in France.
A Multiple-Locus Variable number tandem repeat (VNTR) Analysis typing technique was developed for A. phagocytophilum. Five VNTRs were selected based on the HZ human-derived strain genome, and were tested on the Webster human-derived strain and on 123 DNA samples. This study confirmed that A. phagocytophilum from roe deer or domestic ruminants belong to two different clusters, while A. phagocytophilum from red deer and domestic ruminants locate within the same cluster, questioning the respective roles of roe vs red deer as reservoir hosts for domestic ruminant strains in Europe.
The molecular techniques recently developed have great potential to provide detailed information on A. phagocytophilum isolates, improving both epidemiological and phylogenic investigations, thereby helping in the development of relevant prevention and control measures.
La leishmaniose canine à Leishmania Infantum : actualités épidémiologiques – applications
Authors: Bourdoiseau Gilles 
Published: November 2015

Canine leishmaniosis epidemiological update and applications.
Canine leishmaniosis is a vector-borne disease caused by Leishmania infantum mainly transmitted by the bites of phlebotomine sandflies. The epidemiological role of domestic dogs (safe, asymptomatic, sick or vaccinated) is very important because it is the main source of parasites for the vector. But the proved or potential epidemiological role of wild animals (rabbit, hare,…) require more investigations for a best efficacy. The displacement or importation of infected dogs combined with the climatic modifications contribute to a significative incidence of canine and human clinical cases. Vaccination associated with topical insecticides should be recommanded for dogs living or travelling in endemic areas.
La vaccination dans la gestion des maladies vectorielles : rôles et réponses de l’industrie du médicament vétérinaire
Authors: Ridremont Bertrand , Bolon Arnaud , Poincelot Laure , Cournarie Fabienne 
Published: November 2015

Vaccination in the management of vector-borne diseases : roles and answers of veterinary medicine industry.
Vaccination is an option among the different tools against animal vector-borne diseases. The animal health care industry is often involved in manufacturing vaccines to prevent enzootic diseases (as leishmaniosis) or emerging diseases (as Blue Tongue and Schmallenberg diseases). Cooperation with scientific experts or institutes and governmental organizations is quite essential to coordinate management of such vectorial diseases : examples of networks in terms of research and field application are mentioned. The development of vaccines by the healthcare companies generally takes 7 to 10 years, sometimes more, but, in case of emerging diseases, could be achieved within a few months, with fast availability of such vaccines on the field due to special authorization. Then issues for the pharmaceutical companies are discussed, either on a scientific (R and D) basis or on an economical point of view (Return On Investment). Finally, numerous initiatives are taken by the pharmaceutical industry to favor collaborations in a spirit of open innovation for tomorrow’s innovations.
Examen critique des approches vaccinales pour lutter contre les mammites bovines
Authors: Rainard Pascal 
Published: November 2015

Critical appraisal of vaccine approaches to control bovine mastitis.
Despite their interest to combat mastitis, vaccines are few and underused, owing to limited efficacy. The mammary gland may have established with its pathogens a modus vivendi that favours the settlement of chronic subclinical infections. Reprogramming this immune response in a way that favours bacteriological cure but spares the secretory function presents a major challenge to immunologists. To improve vaccine efficacy, stress should be put on research on T lymphocyte-dependent immune defenses. In this view, improved knowledge of mammary lymphocyte populations, in association with systems vaccinology approaches, should offer new prospects for the development of efficient vaccines.
Impact of a Curricular Change on Perceived Knowledge, Skills, and Use of Evidence in Occupational Therapy Practice: A Cohort Study
Authors: Benevides Teal W. , Vause-Earland Tracey , Walsh Robert 
Published: November 2015

AbstractOBJECTIVE. We evaluated the impact of a curriculum revision that emphasized experiential use of evidence in clinical environments on occupational therapy graduates’ attitudes, perceived knowledge and skill, and use of evidence in practice.METHODS. We used a retrospective cohort design to compare two curriculum cohorts of recent graduates exposed to different evidence-based practice (EBP) educational approaches. Responses on a validated survey of attitudes, knowledge/skill, and use of evidence in practice were compared using t tests and Mann–Whitney U tests for Cohort 1 (n = 63) and Cohort 2 (n = 62) graduates.RESULTS. Findings suggest similar attitudes and use of evidence between cohorts; Cohort 2 reported statistically greater perceived knowledge of and skill in EBP.CONCLUSIONS. Emphasis on experiential learning in school with reinforcement of skills in clinical learning environments is not sufficient to change graduates’ use of evidence. Although the curriculum revision improved perceived knowledge/skill, our study suggests systems or other factors may influence use after graduation.
Over goed en slecht peilen: de casus van de koopzondag
Authors: Bethlehem Jelke 
Published: November 2015

About good and bad polling: the case of Sunday shopping
Polling is being done a great deal in the Netherlands, especially during election campaigns when market researchers sometimes present new polls every day. The national government also takes polls that are often larger and more complicated than the quick and small polls conducted by market research agencies. They are often called surveys, and they gather information on the state of affairs in society. That information can become the basis for new policies. Local governments also take polls, although on a smaller scale than national government. Dutch municipalities have a tradition of organizing omnibus surveys in which (as the name indicates) several subjects can be addressed. Nowadays many ‘omnibus surveys have been replaced by ‘citizen panels’. One thing all these polls and surveys have in common is that they are based on random samples of the population and statements are made about the population as a whole based on these samples. Such generalizations are only possible if the sample is drawn using by random sampling methods. This article describes good and bad polling. This is illustrated using a unique example: the research into the opinion of the inhabitants of Alphen aan den Rijn, a Dutch municipality, on Sunday shopping. At the same time, and using the same questionnaire, three different polls were carried out. This example makes clear that the wrong sample can lead to incorrect conclusions and maybe to incorrect policy decisions.
Heeft de omwenteling in het lokaal bestuur wel plaatsgevonden?
Authors: Schrijver Jan 
Published: November 2015

Has a revolt in local administration really taken place? Doubts on the predicted shift from government to governance
On April 8th 2015, Jan Schrijver got his PhD at Maastricht University (Arno Korsten was his doctoral thesis supervisor) on research into 40 years of Dutch administrative policy (1969 to 2009). This period largely coincided with his career as a senior civil servant (1976 to 2003). The expectation often predicted in Public Administration was that a shift from government to governance (from cockpit thinking to a network society) would occur in the dominant administrative theory. However, this shift was not detected in the Departments of Home Affairs and Agriculture during the research period. In the literature on Dutch local administration, qualitative (and often ambivalent) information is generally to be found. On the one hand, this literature emphasizes the inevitability of this shift and offers a lot of case descriptions. On the other hand, Dutch handbooks on local administration devote little attention to this development and contain many views that point to stubborn administrative methods employed by old-style governors. The author concludes that Dutch national administration converges to one firm, while local administration diverges into a leading group of municipalities and a group of followers.
Relationship of central incisor implant placement to the ridge configuration anterior to the nasopalatine canal in dentate and partially edentulous individuals: a comparative study
Authors: Jia Xueting , Hu Wenjie , Meng Huanxin 
Published: November 2015

Background.The aims of this study were to investigate the ridge contour anterior to the nasopalatine canal, and the difference between the incidences of the nasopalatine canal perforation in dentate and partially edentulous patients by cone-beam computed tomography.Methods.Cone-beam computed tomography scan images from 72 patients were selected from database and divided into dentate and partially edentulous groups. The configuration of the ridge anterior to the canal including palatal concavity depth, palatal concavity height, palatal concavity angle, bone height coronal to the incisive foramen, and bone width anterior to the canal was measured. A virtual implant placement procedure was used, and the incidences of perforation were evaluated after implant placement in the cingulum position with the long axis along with the designed crown.Results.Comparing with variable values from dentate patients, the palatal concavity depth and angle were greater by 0.9 mm and 4°, and bone height was shorter by 1.1 mm in partially edentulous patients, respectively. Bone width in edentulous patients was narrower than in dentate patients by 1.2 mm at incisive foramen level and 0.9 mm at 8 mm subcrestal level, respectively. After 72 virtual cylindrical implants (4.1 × 12 mm) were placed, a total of 12 sites (16.7%) showed a perforation and three-fourths occurred in partially edentulous patients. After replacing with 72 tapered implants (4.3 × 13 mm), only 6 implants (8.3%) broke into the canal in the partially edentulous patient group.Conclusions.The nasopalatine canal may get close to the implant site and the bone width anterior to the canal decreases after the central incisor extraction. The incidence of nasopalatine canal perforation may occur more commonly during delayed implant placement in central incisor missing patients.
Laboratory and clinical trials of cocamide diethanolamine lotion against head lice
Authors: Burgess Ian F. , Brunton Elizabeth R. , Brown Christine M. 
Published: November 2015

Context.During the late 1990s, insecticide resistance had rendered a number of treatment products ineffective; some companies saw this as an opportunity to develop alternative types of treatment. We investigated the possibility that a surfactant-based lotion containing 10% cocamide diethanolamine (cocamide DEA) was effective to eliminate head louse infestation.Settings and Design.Initialin vitrotesting of the lotion formulation versus laboratory reared body/clothing lice, followed by two randomised, controlled, community-based, assessor blinded, clinical studies.Materials and Methods.Preliminary laboratory tests were performed by exposing lice or louse eggs to the product using a method that mimicked the intended use. Clinical Study 1: Children and adults with confirmed head louse infestation were treated by investigators using a single application of aqueous 10% cocamide DEA lotion applied for 60 min followed by shampooing or a single 1% permethrin creme rinse treatment applied to pre-washed hair for 10 min. Clinical Study 2: Compared two treatment regimens using 10% cocamide DEA lotion that was concentrated by hair drying. A single application left on for 8 h/overnight was compared with two applications 7 days apart of 2 h duration, followed by a shampoo wash.Results.The initial laboratory tests showed a pediculicidal effect for a 60 min application but limited ovicidal effect. A longer application time of 8 h or overnight was found capable of killing all eggs but this differed between batches of test material. Clinical Study 1: Both treatments performed badly with only 3/23 (13%) successful treatments using cocamide DEA and 5/25 (23.8%) using permethrin. Clinical Study 2: The single overnight application of cocamide DEA concentrated by hair drying gave 10/56 (17.9%) successes compared with 19/56 (33.9%) for the 2 h application regimen repeated after 1 week. Intention to treat analysis showed no significant difference (p= 0.0523) between the treatments. Over the two studies, there were 18 adverse events possibly or probably associated with treatment, most of which were increased pruritus after treatment.Conclusions.Cocamide DEA 10% lotion, even when concentrated by hair drying, showed limited activity to eliminate head louse infestation.
Electrotransformation and Clonal Isolation of Rickettsia Species
Authors: Riley Sean P. , Macaluso Kevin R. , Martinez Juan J. 
Published: November 2015

AbstractGenetic manipulation of obligate intracellular bacteria of the genus Rickettsia is currently undergoing a rapid period of change. The development of viable genetic tools, including replicative plasmids, transposons, homologous recombination, fluorescent protein‐encoding genes, and antibiotic selectable markers has provided the impetus for future research development. This unit is designed to coalesce the basic methods pertaining to creation of genetically modified Rickettsia. The unit describes a series of methods, from inserting exogenous DNA into Rickettsia to the final isolation of genetically modified bacterial clones. Researchers working towards genetic manipulation of Rickettsia or similar obligate intracellular bacteria will find these protocols to be a valuable reference. © 2015 by John Wiley & Sons, Inc.
p‐Toluenesulfonic Acid‐Mediated Three‐Component Reaction “On‐Water” Protocol for the Synthesis of Novel Thiadiazolo[2,3‐b]quinazolin‐6(7H)‐ones
Authors: Wadhwa Preeti , Kaur Tanpreet , Singh Neetu , Singh Udai P. , Sharma Anuj 
Published: November 2015

AbstractThe first p‐toluenesulfonic acid‐mediated “on‐water” multicomponent reaction sequence for the synthesis of novel thiadiazolo[2,3‐b]quinazolinones from 5‐aryl‐1,3,4‐thiadiazol‐2‐amines, cyclic 1,3‐dicarbonyls and aldehydes with microwave irradiation is described. This protocol proceeds with high atom economy and leads to the generation of three rings, together with one C−C, one C=N and two C−N bonds in a single operation. This new methodology has advantages such as operational simplicity, mild conditions, broad functional group tolerance, simple work‐up procedure and applicability on a gram scale.
Chiral Sulfinamide Bisphosphine Catalysts: Design, Synthesis, and Application in Highly Enantioselective Intermolecular Cross‐Rauhut–Currier Reactions
Authors: Zhou Wei , Su Xiao , Tao Mengna , Zhu Chaoze , Zhao Qingjie , Zhang Junliang 
Published: November 2015

AbstractA novel type of highly efficient chiral sulfinamide bisphosphine catalysts (Wei‐Phos) were developed. These could be easily prepared from commercially available starting materials. Wei‐Phos has shown good performance in the very challenging intermolecular cross‐Rauhut–Currier reactions of vinyl ketones and 3‐acyl acrylates or 2‐ene‐1,4‐diones, leading to the R‐C products in high yields with up to 99 % ee under 2.5–5 mol% catalyst loading. The highly regio‐ and enantio‐selective cross‐Rauhut–Currier reactions of 2‐ene‐1,4‐diones and vinyl ketone have yet reported so far.
A [4+1] Cyclative Capture Approach to 3H‐Indole‐N‐oxides at Room Temperature by Rhodium(III)‐Catalyzed CH Activation
Authors: Yang Yaxi , Wang Xuan , Li Yuanchao , Zhou Bing 
Published: November 2015

AbstractThe rhodium(III)‐catalyzed [3+2] CH cyclization of aniline derivatives and internal alkynes represents a useful contribution to straightforward synthesis of indoles. However, there is no report on the more challenging synthesis of pharmaceutically important N‐hydroxyindoles and 3H‐indole‐N‐oxides. Reported herein is the first rhodium(III)‐catalyzed [4+1] CH oxidative cyclization of nitrones with diazo compounds to access 3H‐indole‐N‐oxides. More significantly, this reaction proceeds at room temperature and has been extended to the synthesis of N‐hydroxyindoles and N‐hydroxyindolines.