bluuebunny/crossref_metadata_2025_split huggingface dataset:
Spin-orbit coupling induced semi-metallic state in the 1/3 hole-doped hyper-kagome Na3Ir3O8
Authors: Takayama Tomohiro , Yaresko Alexander , Matsumoto Akiyo , Nuss Jürgen , Ishii Kenji , Yoshida Masahiro , Mizuki Junichiro , Takagi Hidenori 
Published: October 2014

AbstractThe complex iridium oxide Na3Ir3O8 with a B-site ordered spinel structure was synthesized in single crystalline form, where the chiral hyper-kagome lattice of Ir ions, as observed in the spin-liquid candidate Na4Ir3O8, was identified. The average valence of Ir is 4.33+ and, therefore, Na3Ir3O8 can be viewed as a doped analogue of the hyper-kagome spin liquid with Ir4+. The transport measurements, combined with the electronic structure calculations, indicate that the ground state of Na3Ir3O8 is a low carrier density semi-metal. We argue that the semi-metallic state is produced by a competition of the molecular orbital splitting of t2g orbitals on Ir3 triangles with strong spin-orbit coupling inherent to heavy Ir ions.
A non-resonant mass sensor to eliminate the “missing mass” effect during mass measurement of biological materials
Authors: Shrikanth V. , Bobji M. S. 
Published: October 2014

Resonant sensors and crystal oscillators for mass detection need to be excited at very high natural frequencies (MHz). Use of such systems to measure mass of biological materials affects the accuracy of mass measurement due to their viscous and/or viscoelastic properties. The measurement limitation of such sensor system is the difficulty in accounting for the “missing mass” of the biological specimen in question. A sensor system has been developed in this work, to be operated in the stiffness controlled region at very low frequencies as compared to its fundamental natural frequency. The resulting reduction in the sensitivity due to non-resonant mode of operation of this sensor is compensated by the high resolution of the sensor. The mass of different aged drosophila melanogaster (fruit fly) is measured. The difference in its mass measurement during resonant mode of operation is also presented. That, viscosity effects do not affect the working of this non-resonant mass sensor is clearly established by direct comparison.
An approach to standardize transient expression of GUS in sesame (Sesamum indicum L.) using the Sonication-Assisted Agrobacterium tumefaciens-mediated Transformation (SAAT) method
Authors: Debnath Anirban Jyoti , Basu Debabrata , Sikdar Samir Ranjan 
Published: October 2014

Sonication-Assisted Agrobacterium-mediated Transformation (SAAT) dramatically improved Agrobacterium infection efficiency in Sesamum indicum (sesame) cotyledon. Different parameters of this method such as the duration of sonication, Agrobacterium concentration and acetosyringone concentration during co-cultivation was standardized to develop a balanced protocol that gave optimum β-glucuronidase (GUS) expression with minimal tissue damage. Nine seconds was identified as the optimum duration for sonication. Agrobacterium concentration having OD600 nm 1.0 was found not to induce tissue damage. Usage of 100 μM acetosyringone, which facilitates T-DNA transfer by activating the vir gene in Agrobacterium, increased the transient GUS activity. The optimized protocol facilitated 85.56 ± 0.35% transient GUS activity. Mimicking SAAT by increasing the concentration of acetosyringone during the co-cultivation period to 400 μM in the conventional Agrobacterium-mediated transformation gave only 32.22 ± 1.53% GUS activity. The results suggest that not only acetosyringone but also other compounds were released during formation of micro-wound by sonication that increased the infection efficiency.
The balanced scorecard’s missing link to compensation
Authors: Alexandra Albertsen Oana , Lueg Rainer 
Published: October 2014

Purpose– This paper aims to review the literature on the balanced scorecard (BSC) system. The BSC may well be one of the most popular performance measurement systems, but this is not synonymous with successful. The inventors of the BSC, Kaplan and Norton, actually emphasize that a BSC can only really impact the organizational performance if it is linked to the actors’ intrinsic and extrinsic incentives. As BSC has existed for more than 20 years, the authors find it relevant to survey the extant literature which elaborates on the BSC-incentives link within organizations.Design/methodology/approach– This paper identifies 117 empirical studies from leading academic journals published between 1992 and 2012 and then assesses 30 of these studies, which present the BSC-compensation link within the BSC literature. The authors analyze both research design (authors’ perspective) and the actual findings in the field (organizations’ perspective).Findings– First, it was found that only 30 of 117 empirical studies have a research design that is comprehensive enough to capture a full BSC as suggested by Kaplan and Norton, and only six of these studies elaborate on the link between the BSC and compensation. Second, extant research lacks valid constructs for the BSC and focuses too much on planning (ex-ante) with the BSC and not sufficiently on evaluation and control (ex-post). Third, the authors demonstrate that empirical BSC literature relies very strongly on field research in small and medium enterprises compared to similar research. Overall, the authors claim that the “relevance” of the BSC remains unproven.Originality/value– The authors synthesize the empirical BSC literature and derive a future research agenda.
The view from industry: LIS students on placement
Authors: Pymm Bob , Juznic Primoz 
Published: October 2014

Purpose
– This paper aims to report on the outcomes of a survey of organisations in Australia and Slovenia hosting undergraduate Library and Information Studies (LIS) students on professional placement to better understand the reasons behind organisations accepting students, the workload implications and their satisfaction with the process.

Design/methodology/approach
– Hosting organisations were asked to complete a survey on various aspects of the placement process.

Findings
– For both countries, hosts reported favourably on their experience, and virtually, all felt that while it was a real commitment of time and resources on their part, it was a responsibility they were happy to take on. There was little difference between the two cohorts, suggesting that the findings from this research may be an accurate picture of the situation for LIS placements hosts more generally. The positive view of the placement and the belief in its role in LIS education is further strengthened by this study.

Research limitations/implications
– The research suggests that hosting students is not seen as an onerous task, but one which brings benefits to both parties. This will be useful in promoting student placements when looking for new host opportunities.

Originality/value
– This study has added to the limited literature in the LIS field on the experience of host organisations. Obtaining similar results across two countries added to the reliability of the findings which will help inform those planning future student placements.
Internalization theory, entrepreneurship and international new ventures
Authors: Verbeke Alain , Amin Zargarzadeh M. , Osiyevskyy Oleksiy 
Published: October 2014

Purpose– The aim of the article is to establish robust linkages between internalization theory and the empirical phenomenon of international new ventures (INVs). Here, the focus is on firm-specific advantages (FSAs) critical to early new venture internationalization.Design/methodology/approach– On the conceptual level, we explain how the INV literature can easily be accommodated using an internalization theory lens, and we formulate hypotheses to that effect. On the empirical level, we use the Kauffman Firm Survey (KFS) dataset, which includes a panel of 4,928 US-based new businesses founded in 2004, tracked over their early years of operations. We use logistic regressions building upon pooled cross-sections, and including lagged dependent variables.Findings– INV-type foreign expansion is a special case of international growth, easily and credibly predicted by internalization. No new theory beyond internalization theory is needed to explain this phenomenon.Originality/value– The early stages of the Uppsala model, in terms of requisite resources accumulation and recombination, may have been undertaken at the individual level, by founding entrepreneurs, in the pre-stage of the new venture, and are “invisible” when focusing on organizational experience built up in the new venture. Here, particular founding entrepreneurs’ characteristics function as FSAs.
Social enterprise as poverty reducing strategy for women
Authors: Fotheringham Sarah , Saunders Chad 
Published: October 2014

Purpose– The purpose of this study is to investigate the potential of social enterprise as a strategy for poverty reduction for women.Design/methodology/approach– A literature synthesis on the topic was conducted and patterns, linkages and gaps were examined among key themes to identify how social enterprise can potentially serve as a poverty reduction strategy for women.Findings– The paper presents the findings in terms of specific factors contributing to women’s poverty and hypothesizes mechanisms through which social enterprises can mitigate or address these factors in practice. The paper organizes these findings in an integrative framework that highlights the need to ensure a solid policy foundation is in place before a number of key support mechanisms are enabled, which then facilitate specific types of work that can then grow in a sustainable manner.Research limitations/implications– While the mechanisms and proposed framework are based on the extant literature, additional empirical investigation is required.Practical implications– Women are disproportionately burdened by poverty and the framework presented provides a very practical tool to guide the design of new or diagnosing existing social enterprises targeting poverty reduction for women.Social implications– Without a strategic approach, the risk is either perpetuating the status quo, or worse, placing those women engaged in social enterprises in a worse financial and social position.Originality/value– There is limited research on the poverty reducing role of social enterprise for women and the proposed mechanisms and integrative framework presented provide a means of synthesizing our current knowledge while providing the basis for future investigations.
Selective serotonin reuptake inhibitor prescribing before, during and after pregnancy: a population‐based study in six European regions
Authors: Charlton RA , Jordan S , Pierini A , Garne E , Neville AJ , Hansen AV , Gini R , Thayer D , Tingay K , Puccini A , Bos HJ , Nybo Andersen AM , Sinclair M , Dolk H , de Jong‐van den Berg LTW 
Published: October 2014

ObjectiveTo explore the prescribing patterns of selective serotonin reuptake inhibitors (SSRIs) before, during and after pregnancy in six European population‐based databases.DesignDescriptive drug utilisation study.SettingSix electronic healthcare databases in Denmark, the Netherlands, Italy (Emilia Romagna/Tuscany), Wales and the rest of the UK.PopulationAll women with a pregnancy ending in a live or stillbirth starting and ending between 2004 and 2010.MethodsA common protocol was implemented across databases to identify SSRI prescriptions issued (UK) or dispensed (non‐UK) in the year before, during or in the year following pregnancy.Main outcome measuresThe percentage of deliveries in which the woman received an SSRI prescription in the year before, during or in the year following pregnancy. We also compared the choice of SSRIs and changes in prescribing over the study period.ResultsIn total, 721 632 women and 862 943 deliveries were identified. In the year preceding pregnancy, the prevalence of SSRI prescribing was highest in Wales [9.6%; 95% confidence interval (CI95), 9.4–9.8%] and lowest in Emilia Romagna (3.3%; CI95, 3.2–3.4%). During pregnancy, SSRI prescribing had dropped to between 1.2% (CI95, 1.1–1.3%) in Emilia Romagna and 4.5% (CI95, 4.3–4.6%) in Wales. The higher UK pre‐pregnancy prescribing rates resulted in higher first trimester exposures. After pregnancy, SSRI prescribing increased most rapidly in the UK. Paroxetine was more commonly prescribed in the Netherlands and Italian regions than in Denmark and the UK.ConclusionsThe higher SSRI prescribing rates in the UK, compared with other European regions, raise questions about differences in the prevalence and severity of depression and its management in pregnancy across Europe.
Dysregulation of circulating CD4+CXCR5+ T cells in type 2 diabetes mellitus
Authors: Wang Qijin , Zhai Xiao , Chen Xiao , Lu Jiancan , Zhang Yaping , Huang Qin 
Published: October 2014

Type 2 diabetes mellitus (T2DM) is characterized by a chronic low‐grade inflammatory state. Follicular helper T cells (Tfh) play critical roles in inducing B‐cell activation and producing various cytokines, whereas circulating CD4+CXCR5+ T cells (CTfh) may act as a counterpart to measure Tfh cell disorders. In this study, we investigated whether Tfh could be involved in the development of T2DM by assessing CTfh in peripheral blood. CTfh and it subtypes were determined by measuring CD3, CD4, CXCR5, CXCR3, and CCR6 in 68 T2DM patients and 60 healthy controls using flow cytometry. Results showed that proportion of CTfh in the peripheral CD4+ T cells was significantly increased in T2DM patients (8.5 ± 0.5%) than in controls (4.5 ± 0.3%) (p < 0.001). Further study revealed that the balance of CTfh subtypes was greatly dysregulated, in which percentage of Th17 subtype was significantly increased in patients. Investigating the correlation between CTfh and risk factors of T2DM demonstrated that proportion of CTfh were significantly elevated in patients with body mass index (BMI) over 24.0 (p = 0.005). Interestingly, patients with abdominal obesity had further increase in CTfh than those without abdominal obesity. This study suggests the involvement of CTfh in T2DM, especially in T2DM‐related obesity.
Laparoscopic mesh repair of a Morgagni hernia using the double‐crown technique: A case study
Authors: Kaida Takeshi , Ikeda Atsushi , Shimoda Hirofumi , Sako Hiroyuki , Uchida Hiroshi , Wada Masahiro , Ikeda Ken , Okusawa Seijiro , Watanabe Masahiko 
Published: October 2014

AbstractWe report a case of Morgagni hernia in which the patient underwent laparoscopic mesh repair. A 65‐year‐old woman presented with an abnormal shadow in the right lower lung field on a routine medical checkup. CT showed that the transverse colon passed between the liver and abdominal wall, and herniated into the thoracic cavity. Simple closure was precluded by the large hernial orifice. We therefore performed laparoscopic repair using a Parietex Optimized Composite Mesh. The double‐crown technique was used to fix the margin of the mesh to the region around the hernial orifice. Our procedure for repair of a Morgagni hernia with a large hernial orifice is safe and minimally invasive, and it may effectively prevent recurrence.
Power calculation for comparing diagnostic accuracies in a multi‐reader, multi‐test design
Authors: Kim Eunhee , Zhang Zheng , Wang Youdan , Zeng Donglin 
Published: October 2014

SummaryReceiver operating characteristic (ROC) analysis is widely used to evaluate the performance of diagnostic tests with continuous or ordinal responses. A popular study design for assessing the accuracy of diagnostic tests involves multiple readers interpreting multiple diagnostic test results, called the multi‐reader, multi‐test design. Although several different approaches to analyzing data from this design exist, few methods have discussed the sample size and power issues. In this article, we develop a power formula to compare the correlated areas under the ROC curves (AUC) in a multi‐reader, multi‐test design. We present a nonparametric approach to estimate and compare the correlated AUCs by extending DeLong et al.'s (1988, Biometrics 44, 837–845) approach. A power formula is derived based on the asymptotic distribution of the nonparametric AUCs. Simulation studies are conducted to demonstrate the performance of the proposed power formula and an example is provided to illustrate the proposed procedure.
Sequential Multiple Assignment Randomized Trial (SMART) with Adaptive Randomization for Quality Improvement in Depression Treatment Program
Authors: Cheung Ying Kuen , Chakraborty Bibhas , Davidson Karina W. 
Published: October 2014

Summary
Implementation study is an important tool for deploying state-of-the-art treatments from clinical efficacy studies into a treatment program, with the dual goals of learning about effectiveness of the treatments and improving the quality of care for patients enrolled into the program. In this article, we deal with the design of a treatment program of dynamic treatment regimens (DTRs) for patients with depression post-acute coronary syndrome. We introduce a novel adaptive randomization scheme for a sequential multiple assignment randomized trial of DTRs. Our approach adapts the randomization probabilities to favor treatment sequences having comparatively superior Q-functions used in Q-learning. The proposed approach addresses three main concerns of an implementation study: it allows incorporation of historical data or opinions, it includes randomization for learning purposes, and it aims to improve care via adaptation throughout the program. We demonstrate how to apply our method to design a depression treatment program using data from a previous study. By simulation, we illustrate that the inputs from historical data are important for the program performance measured by the expected outcomes of the enrollees, but also show that the adaptive randomization scheme is able to compensate poorly specified historical inputs by improving patient outcomes within a reasonable horizon. The simulation results also confirm that the proposed design allows efficient learning of the treatments by alleviating the curse of dimensionality.
Reduced filaggrin expression is accompanied by increased Staphylococcus aureus colonization of epidermal skin models
Authors: van Drongelen V. , Haisma E. M. , Out‐Luiting J. J. , Nibbering P. H. , El Ghalbzouri A. 
Published: October 2014

SummaryBackgroundAtopic dermatitis is an inflammatory skin disease that is characterized by a reduced skin barrier function, reduced filaggrin (FLG) expression as well as increased colonization by Staphylococcus aureus.ObjectiveThis study focused on the possible involvement of FLG in epidermal colonization by S. aureus and/or whether it affects the epidermal defence mechanisms, including the expression of antimicrobial peptides (AMPs) and enzymes involved in stratum corneum barrier lipid synthesis. Furthermore, IL‐31 has been shown to reduce FLG expression, but its effects on bacterial colonization and on the expression of AMPs and enzymes involved in the barrier lipid synthesis are not known.Material and MethodsWe established N/TERT‐based epidermal models (NEMs), after FLG knockdown (FLG‐KD) and/or cultured with IL‐31, that were colonized with S. aureus for 24 h.ResultsBoth FLG‐KD and IL‐31 supplementation resulted in significantly increased epidermal S. aureus colonization, as well as in an up‐regulation of S. aureus‐induced IL‐8 expression. IL‐31, but not FLG‐KD, prevented S. aureus‐induced up‐regulation of mRNA expression for the AMPs human β‐defensin 2 and ‐3 and RNAse7, whereas psoriasin expression remained unchanged. Furthermore, the S. aureus colonization induced changes in mRNA expression of ELOVL4 was not affected by FLG‐KD, but was blocked by IL‐31. Expression of SCD‐1 and Gcase mRNA was reduced by IL‐31, but not by FLG‐KD.ConclusionThis study shows that NEMs, with FLG‐KD and/or cultured in the presence of IL‐31, mimic the skin of patients with atopic dermatitis in several aspects, including enhanced bacterial colonization, increased inflammatory and reduced protective responses.
Sex ratio of congenital abnormalities in the function of maternal age: A population‐based study
Authors: Csermely Gyula , Urbán Robert , Czeizel Andrew E , Veszprémi Béla 
Published: October 2014

AbstractMaternal age effect is well‐known in the origin of numerical chromosomal aberrations and some isolated congenital abnormalities (CAs). The sex ratio (SR), i.e. number of males divided by the number of males and females together, of most CAs deviates from the SR of newborn population (0.51). The objective of this analysis was to evaluate the possible association of maternal age with the SR of isolated CAs in a population‐based large dataset of the Hungarian Case‐Control Surveillance of Congenital Abnormalities, 1980–1996. First, SR of 24 CA entities/groups was estimated in 21 494 patients with isolated CA. In the next step SR of different maternal age groups was compared to the mean SR of the given CA‐groups. The SR of four CA‐groups showed some deviation in certain maternal age groups. Cases with anencephaly had female excess in young mothers (<25 years). Cases with skull's CAs particularly craniosynostosis had a male excess in cases born to women over 30 years. Two other CA groups (cleft lip ± palate and valvar pulmonic stenosis within the group of right‐sided obstructive defect of heart) had significant deviation in SR of certain maternal age groups from the mean SR, but these deviations were not harmonized with joining age groups and thus were considered as a chance effect due to multiple testing. In conclusion, our study did not suggest that in general SR of isolated CAs might be modified by certain maternal age groups with some exception such as anencephaly and craniosynostosis.
If it does not significantly change HbA1c levels why should we waste time on it? A plea for the prioritization of psychological well‐being in people with diabetes
Authors: Jones A. , Vallis M. , Pouwer F. 
Published: October 2014

AbstractDespite improvements in pharmacological treatments and methods of care and care delivery, the burden of living with diabetes remains an ongoing challenge, as many people with diabetes are at increased risk of mental health disorders, psychological disturbances and functional problems associated with living with diabetes. Person‐centred collaborative care that also meets the psychological needs of the individual is not available to many people with diabetes. The present article examines the role of psychological factors in the onset of diabetes and in relation to living with diabetes. It is argued that the pursuit of psychological well‐being is worthy of individual attention in the care of people with diabetes and should not be contingent upon attainment of somatic indices of health. The barriers to attaining this goal are examined, including the costs of treating (or not treating) psychological problems in people with diabetes. Recommendations on how to improve diabetes care are offered, including psychological interventions that are both evidence‐based and cost‐effective.