bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic markers identify duplicates in Nordic potato collections
Authors: Chrominski Pawel , Carlson-Nilsson Ulrika , Palmé Anna , Kirk Hanne Grethe , Asdal Åsmund , Ansebo Lena 
Published: August 2024

IntroductionThe first small scale cultivation of potatoes in the Nordic countries began roughly 300 years ago, and later became an important staple food in the region. Organized conservation efforts began in the 1980s, and today, potato landraces, improved varieties, and breeding lines are conserved in genebanks at the Nordic Genetic Resource Center (NordGen), Sweden, and the Norwegian Genetic Resource Centre (NGS), Norway, as well as at potato breeding companies across Nordic countries. All these collections house a diverse array of genotypes with local names and local growing histories from the whole region. However, the presence of duplicates, and inconsistent naming has led to confusion.MethodsIn this study, 198 accessions of cultivated potato (Solanum tuberosum L.) have been genotyped with 62 microsatellite (SSR) markers. The analyzed accessions came from three collections: 43 accessions from the Danish Potato Breeding Foundation in Vandel (LKF-Vandel), 90 from NordGen and 65 from NGS.Results and discussionThe genetic analysis revealed 140 unique potato genotypes and 31 groups/clusters of duplicates, most of which contained duplicate pairs and the others three to ten accessions. Several accessions with distinct names were genetically identical or very similar, suggesting historical sharing, and regional distribution of seed potatoes, leading to the emergence of diverse local names. Moreover, many improved varieties from early potato breeding were revealed to have duplicates that have been considered Nordic landraces. Furthermore, potato accessions with identical names but originating from different collections were confirmed to be duplicates. These findings have already influenced management decisions and will further improve management practices for Nordic potato collections. Additionally, this new knowledge will benefit Nordic potato breeding efforts and allow for the dissemination of more accurate information to other users of potato diversity.
Psychological status of medical security teams in Winter Olympic Games and Paralympics under COVID-19
Authors: Zhu Xiaoyu , Zhu Yu , Qi Zhiwei , Li Ran , Tan Yunlong , Yang Zhongwei 
Published: August 2024

BackgroundMedical security work for the 2022 Beijing Winter Olympic and Paralympics faced enormous challenges under COVID-19. This study aimed to investigate the mental status of those medical team members to provide a reference for scientifically implementing medical security services for large-scale events.MethodsIn this prospective cohort study, the Patient Health Questionnaire-9, Self-rating Anxiety Scale, General Self-Efficacy Scale, and Psychological Questionnaire for Emergent Events of Public Health (PQEEPH) were administered to 145 members of the medical team. A generalized mixed linear model was used to analyze the impact of work duration, position, on/off rotation, and gender on psychological status.ResultsWork duration significantly impacted depression, anxiety, self-efficacy, and all dimensions of PQEEPH. Women scored higher than men in the PQEEPH dimensions of depression, neurasthenia, fear, and total score. Working status affected the dimensions of depression, neurasthenia, and total score. Deterioration in emotional state became apparent in the fourth week and recovered 1 week after the task concluded, while self-efficacy decreased from beginning to end.ConclusionAll the medical team members experienced emotional deterioration and decreased self-efficacy in medical security tasks. To maintain a medical team’s psychological wellbeing during large-scale activities, rotation times should be set reasonably, and adequate mental health services should be provided.
Mapping competency profiles of schools of public health: implications for public health workforce education and training in Israel
Authors: Neumark Yehuda , Hannink Attal Jordan , Shapiro Naham , MacLeod Fiona , Harrington Janas , Barach Paul , de Nooijer Jascha , Dopelt Keren , Duplaga Mariusz , Leighton Lore , Levine Hagai , Mor Zohar , Otok Robert , Paillard-Borg Stephanie , Tulchinsky Ted , Zelber-Sagi Shira , Malowany Maureen 
Published: August 2024

AimCompetency frameworks are essential for analyzing capabilities of Schools of Public Health to adequately prepare public health (PH) professionals to address contemporary challenges. This study maps the competency profiles of PH training programs in Israel using a novel curriculum mapping tool.MethodsThis study assessed all five Israeli Health Education Institutions (HEIs) offering MPH or Bachelors in Public Health (BPH) degrees across 57 competencies in six domains to determine the extent to which competencies were addressed in the curriculum. The competencies list was based on the Association of Schools of Public Health in the European Region (ASPHER) List of Core Competences for the Public Health Professional, adapted for Israeli HEIs.ResultsThe core curricula in the four MPH programs addressed 45–84% of all competencies. The BPH program addressed 79% of competencies. In MPH programs, the core curricula addressed most or all competencies in the Methods and the Socioeconomic Determinants of Health domains. Competencies in the domains of Environmental Determinants of Health, Health Policy, Economics &amp; Organization, and Health Promotion and Prevention were less comprehensively addressed in most core curricula. Students’ opportunities to broaden their exposure to competencies outside the core curricula were context dependent.DiscussionThe curriculum competencies mapping tool that was developed served to assess both strengths and shortcomings in PH education in Israel. The findings demonstrate a highly variable array of PH curriculum models in Israeli HEIs, as well as overall shortcomings in the Environmental, Health Policy Economics and Organization, and Health Promotion and Prevention domains. This analysis has already led to reassessment of the curriculum, and will continue to guide the next steps to increase the harmonization of PH training curricula and to better meet PH challenges in Israel.
Translation, cross-cultural adaptation and validation of the universal Welch Emotional Connection Screen using primary and bilingual Spanish-speaking coders of videotaped mother-child interactions
Authors: Hane Amie A. , Ludwig Robert J. , Martinez Amy G. , Masese Cynthia , Vanhatalo Ulla , Goddard Cliff , Jaffe Marc E. , Myers Michael M. , Welch Martha G. 
Published: August 2024

IntroductionUsing clear explicit translatable language, we translated the Welch Emotional Connection Screen into a new universal language instrument, the English uWECS. In this study, we had two aims: Aim 1 was to establish concurrent validity of the uWECS by comparing scores coded by primary Spanish-speaking coders using the Spanish translation of the uWECS to scores coded by bilingual, secondary Spanish-speaking coders using the oWECS. Aim 2 was to establish the criterion-related validity in terms of oWECS and uWECS performance in tracking change in autonomic emotional connection (AEC) during the course of an intervention among preschool aged children.MethodsWe created a library of 52 five-minute Spanish-speaking mother-child videos that were collected during a randomized controlled trial of Mother-Child Emotional Preparation intervention (MCEP). The videos were collected at two time points, at enrollment and at a 6-month follow-up. The subsample of Primary Spanish-Speaking dyads from the MCEP study were coded by two independent teams of coders. We trained primary English-speaking (bilingual Spanish) coders on the oWECS, using the original training program. A different team of primary Spanish-speaking coders coded the same cases using the novel uWECS guide and trained briefly for reliability with the Spanish uWECS translation materials.ResultsWe found that the Spanish oWECS and Spanish uWECS ratings from the baseline and 6-month follow-up observations were robustly correlated, with intraclass correlations ranging from .81 to .84 and all p-values&lt;.001, thus demonstrating sound concurrent validity for the uWECS. The oWECS and uWECS scores also achieved parallel results when evaluating the efficacy of the MCEP for primary Spanish-speaking dyads. Both the AEC scores of the oWECS [F(1, 27) = 4.31, p &lt; .05] and the scores of the uWECS [F(1,27) = 4.06, p &lt; .05] similarly demonstrated significant change post intervention, thus demonstrating sound criterion-related validity of the uWECS.DiscussionThese findings demonstrate that the uWECS can be used to measure parent/child AEC in linguistically diverse populations and cultures.
Mirabegron 50 mg once daily, long-term treatment maximizes benefit in middle-aged and older people with overactive bladder syndrome: a systematic review and meta-analysis of nine phase II/III, randomized, double-blind, parallel-design, placebo-controlled, multicenter, and multinational trials
Authors: Zhang Xiangxiang , Mao Yinhui , Liu Yang , Sun Jilei , Sun Juntao , Pan Chenli , Wang Zhuo , Wei Zhitao , Yang Yong 
Published: August 2024

The prevalence and severity of overactive bladder increase with age, and mirabegron is an approved treatment for this condition. This meta-analysis systematically evaluated the efficacy and safety of mirabegron compared with placebo for overactive bladder treatment. We searched PubMed and the Cochrane Library (30 October 2023) for relevant articles (source: MEDLINE, EMBASE, ClinicalTrials.gov, ICTRP, CINAHL). We included randomized controlled trials involving adults with overactive bladder syndrome that compared mirabegron with placebo treatment. Data were analyzed according to the Cochrane Handbook for Systematic Reviews of Interventions [Review Manager (computer program) Version 5.4]. Nine parallel-group trials (10 articles) were included. The evaluation included a total of 8,527 adults, including 6,445 women and 2,082 men, of whom 5,726 were White, 2,462 were Asian, and 161 were Black. The mean age of the participants ranged from 53.4 to 60.3 years. This evaluation involved three specifications of mirabegron: 25 mg, 50 mg, and 100 mg. In all trials, patients were enrolled in a 12-week double-blind treatment period, and the dose was once daily. The review of trials found that on average, people taking mirabegron had about 13 ml more volume voided per micturition, five fewer micturitions, and four fewer incontinence episodes every week, with moderate improvements in quality of life. About one in five people taking the drug reported TRAEs. Mirabegron treatment is well tolerated, with the risk of adverse events similar to that of a placebo. For best results, a dose of 50 mg once daily is recommended for long-term use. It is unclear whether any benefits are sustained after treatment discontinuation.Systematic Review Registration: https://www.crd.york.ac.uk/prospero/, PROSPERO (CRD42023430737).
Diagnostic challenges in patients with Castleman disease, a single center experience from Hungary
Authors: Brúgós Boglárka , Simon Zsófia , Méhes Gábor , Illés Árpád , Pfliegler György 
Published: August 2024

Castleman disease is a rare and atypical lymphoproliferative disorder characterized by diverse clinical manifestations. It has both unicentric and multicentric forms, the latter with further subdivisions, i.e., human herpesvirus 8-associated and idiopathic forms. The diagnosis of Castleman disease is often delayed, as it is rare, and because it shares clinical features with different autoimmune, inflammatory, and malignant lymphoproliferative disorders. The first-line treatment in unicentric form is mainly surgical, while in idiopathic Castleman disease, anti-interleukin-6 treatment is the therapy of choice. In virus-associated diseases, antiretroviral therapy and rituximab are recommended. In Hungary, only a few cases of Castleman disease have been published. This report presents our two decades of experience in the challenging diagnosis and management of this rare disorder, most properly underdiagnosed in Hungary. We provide insights into seven unicentric and five idiopathic multicentric Castleman disease cases, the latter ones especially highlighting the diagnostic and therapeutic challenges due to the variable and unique clinical features both of patients and diseases, e.g., bronchiolitis obliterans, stage IV diabetic renal failure, anti-HBc positivity, siltuximab treatment period, respectively.
Profiling of the Citrus Leaf Endophytic Mycobiota Reveals Abundant Pathogen-Related Fungal Groups
Authors: Huang Feng , Ling Jinfeng , Cui Yiping , Guo Bin , Song Xiaobing 
Published: August 2024

Plant endophytic microbial communities consist of many latent plant pathogens and, also, many pathogen-related species with reduced virulence. Though with a long history of co-evolution, the diversity and composition of the endophytic mycobiota, especially the pathogen-related fungal groups, has been under-investigated in Citrus (C.). Based on the amplicon sequencing of fungal internal transcribed spacer (ITS), the leaf endophytic mycobiota were profiled on citrus varieties from different citrus-producing regions. The pomelo variety shared significantly distinctive leaf mycobiota when compared to the mandarin and sweet orange; these conform to their host genetic relationships. In addition, a data set of 241 citrus-related fungi, including 171 (71%) pathogens and potential pathogens, was summarized from previous studies. Under the criteria of local BLAST (covered ITS nucleotide ≥ 150 bp, sequence identity ≥ 99%), a total of 935 fungal operational taxonomic units (OTUs) were assigned to 62 pathogen-related fungal groups, representing 14.9% of the relative abundance in the whole community. Of which, the top groups consisted of Colletotrichum gloeosporioides (mean relative abundance, 4.3%), Co. citricola and Co. karstii (2.7%), Zasmidium citri-griseum (2.4%), and Z. fructigenum (1.4%). At the genus level, the ratio of the pathogen-related fungal groups in 64% of fungal genera (16 out of 25) exceeded 50%, which are the solely or mainly occurring fungi of their genus in citrus. Our study suggests that the leaf endophytic compartment may be an important place for the growth of latent pathogens.
Fuzzy Evaluation Model for Operational Performance of Air Cleaning Equipment
Authors: Chen Kuen-Suan , Huang Tsun-Hung , Yu Chun-Min , Lee Hui-E 
Published: August 2024

Global warming has led to the continuous deterioration of the living environment, in which air quality directly affects human health. In addition, the severity of the COVID-19 pandemic has further increased the attention to indoor air quality. Indoor clean air quality is not only related to human health but also related to the quality of the manufacturing environment of clean rooms for numerous high-tech processes, such as semiconductors and packaging. This paper proposes a comprehensive model for evaluating, analyzing, and improving the operational performance of air cleaning equipment. Firstly, three operational performance evaluation indexes, such as the number of dust particles, the number of colonies, and microorganisms, were established. Secondly, the 100(1− α)% upper confidence limits of these three operational performance evaluation indexes were deduced to construct a fuzzy testing model. Meanwhile, the accumulated value of ϕ was used to derive the evaluation decision-making value. The proposed model can help companies identify the key quality characteristics that need to be improved. Furthermore, the competitiveness of cooperative enterprises towards smart manufacturing can be strengthened, so that enterprises can not only fulfill their social responsibilities while developing the economy but also take into account the sustainable development of enterprises and the environment.
Impact of Transgenic Maize Ruifeng125 on Diversity and Dynamics of Bacterial Community in Rhizosphere Soil
Authors: Hao Chaofeng , Xia Xinyao , Xu Chao , Sun Hongwei , Li Fan , Yang Shuke , Xu Xiaohui , Lu Xingbo 
Published: August 2024

With the development of commercialized planting of genetically modified crops, their ecological security risks remain a key topic of public concern. Insect-resistant genetically modified maize, Ruifeng125, which expresses a fusion Bt protein (Cry1Ab-Cry2Aj), has obtained the application safety certificate issued by the Chinese government. To determine the effects of Ruifeng125 on the diversity and dynamics of bacterial communities, the accumulation and degradation pattern of the fusion Bt protein in the rhizosphere soil of transgenic maize were detected. Results showed that the contents of Bt protein varied significantly at different developmental stages, but after straw was returned to the field, over 97% of Bt proteins were degraded quickly at the early stages (≤10 d) and then they were degraded at a relatively slow rate. In addition, the variations in bacterial community diversity in the rhizosphere soil were detected by 16S ribosomal RNA (Rrna) high-throughput sequencing technology. A total of 44 phyla, 435 families, and 842 genera were obtained by 16S rRNA sequencing, among which Proteobacteria, Actinobacia, Acidobacter Acidobacterium, and Chloroflexi were the dominant taxa. At the same developmental stage, no significant differences in soil bacterial diversity were detected between Ruifeng125 and its non-transgenic control variety. Further analysis revealed that developmental stage, rather than the transgenic event, made the greatest contribution to the changes in soil microbial diversity. This research provides important information for evaluating the impacts of Bt crops on the soil microbiome and establishes a theoretical foundation for their environmental safety assessment.
Generation of UV Ellipsoidal Pulses by 3D Amplitude Shaping for Application in High-Brightness Photoinjectors
Authors: Hoffmann Andreas , Good James , Gross Matthias , Krasilnikov Mikhail , Stephan Frank 
Published: August 2024

Photocathode laser pulse shaping is a crucial technology for enhancing the performance of X-ray free-electron lasers by optimizing the quality of electron beams generated from photocathodes within high-gradient radio frequency guns. By precisely shaping these laser pulses, it is possible to significantly reduce the transverse emittance of produced electron bunches. The optimal pulse shape is an ellipsoidal distribution, commonly referred to as the Kapchinskij–Vladimirskij profile. A pulse-shaping scheme utilizing a commercial Yb:KGW laser operating at 514 nm with a repetition rate of 1 MHz and duration of 260 fs has been developed for generating electron bunches with high peak and average power. This study presents the experimental realization of ellipsoidal pulses via three-dimensional amplitude shaping using spatial light modulators at 514 nm, followed by conversion to UV (257 nm) suitable for Cs 2Te photocathodes. The preservation of pulse shape and a high conversion efficiency during this process are investigated and our experiments pave the way for future emittance minimization for X-ray free-electron lasers.
PEMBERDAYAAN MASYARAKAT MELALUI PEMANFAATAN BUAH TOMAT (Solanum lycopersium) DALAM UPAYA PENCEGAHAN RESIKO PENYUMBATAN PEMBULUH DARAH DI RW 16, KELURAHAN CIPAGERAN, KECAMATAN CIMAHI UTARA
Authors: Noviar Ganjar , Hayati Eem , Ramadhani Riski Nur , Nurhayati Betty 
Published: August 2024

Pada pasien hipertensi terjadi hiperagregasi trombosit. Hiperagregasi trombosit akan memberikan keluaran yang buruk pada stroke infark akut, berupa kematian atau defisit neurologic. Salah satu spesies tanaman dapat berperan mencegah terjadinya komplikasi hiperagregrasi adalah buah tomat (Solanum lycopersicum) yang merupakan tanamanhortikultura yang dibudidayakan di Indonesia. Kandungan senyawa dalam buah tomat (Solanum lycopersicum) diantaranya solanin (0,007 %), saponin, asam folat, asam malat, asam sitrat, bioflavonoid (termasuk likopen, α dan ß-karoten), protein, lemak, vitamin, mineral dan histamin yang berfungsi sebagai antiagregasi. Penelitian ini menggunakan 2 metode, yaitu metode survei, dan sampling untuk menentukan cakupan pemberdayaan dan diedukasi berupa penyuluhan dan pendampingan. Selain itu, metode lain yang digunakan

adalah metode edukasi berupa penyuluhan dan pendampingan untuk memberikan pemahaman tentang pemanfaatan buah tomat sebagai pencegahan resiko penyumbatan pembuluh darah. Hasil penelitian sebanyak 20 orang kader dengan presentasi kenaikan 51.67%, sedangkan hasil dari 20 orang warga dengan presentasi kenaikan 75.06%. Hasil uji Wilcoxon dengan nilai p (Sig) < 0,05. Hal ini menunjukkan bahwa terdapat perbedaan nilai yang bermakna antara nilai pre-test dengan nilai post-test kader dan warga RW. 16 Kelurahan Cipageran, Kecamatan Cimahi Utara, Kota Cimahi.
HUBUNGAN PENGETAHUAN DAN SIKAP DENGAN PERILAKU PENCEGAHAN SKABIES PADA REMAJA PUTRI DI MADRASAH ALIYAH
Authors: Adilah Shofiyyah , Ashar Yulia Khairina , Agustina Dewi 
Published: August 2024

Skabies merupakan penyakit kulit menular yang banyak terjadi di daerah pemukiman dengan kepadatan penduduk yang tinggi seperti pondok pesantren. Penyakit ini jika tidak ditangani dengan baik akan mengganggu kenyamanan dan dapat menghambat pencapaian hasil belajar. Tujuan penelitian adalah untuk mengetahui bagaimana perilaku pencegahan skabies remaja putri di Madrasah Aliyah Al-Uswah. Penelitian ini dilakukan di bulan februari 2024 di Pondok Pesantren Al-Uswah Kuala Kabupaten Langkat. Penelitian ini adalah penelitian kuantitatif dengan desain studi cross-sectional.Populasinya berjumlah 100 remaja putri.Sampel dalam penelitian ini menggunakan total sampling dengan jumlah 100.Instrumen yang digunakan berupa kuesioner perilaku pencegahan skabies. Perilaku dalam menghentikan penyebaran penyakit skabies merupakan variabel terikat, sedangkan pengetahuan dan sikap merupakan Variabel bebas. Berdasarkan hasil penelitian 54% responden menunjukkan perilaku negatif untuk menghentikan penyebaran skabies, 10% responden memiliki sikap yang kurang, dan 55% responden kurang mendapatkan informasi yang tepat. Hasil uji Chi-Square menunjukkan ada hubungan antara sikap dengan perilaku (p=0,002) dan antara pengetahuan dengan perilaku (p=0,019) dalam mencegah penyebaran penyakit skabies. Dari temuan tersebut dapat disimpulkan bahwa pada remaja putri yang bersekolah di Madrasah Aliyah Pondok Pesantren Al Uswah terdapat hubungan antara pengetahuan, sikap, dan perilaku untuk menghindari penyebaran penyakit skabies. Direkomendasikan untuk melakukan upaya promotif dan preventif seperti edukasi masyarakat tentang Perilaku Pencegahan Skabies dan penyelenggaraan Poskestren (Pos Kesehatan Pesantren) diperlukan koordinasi dengan petugas kesehatan setempat.
lepra e a tarkat
Authors: Dallacqua de Carvalho Leonardo 
Published: August 2024

Este estudo busca explorar, em perspectiva histórica, a representação de uma doença no jogo eletrônico Mortal Kombat 1 (2023). No jogo, a fictícia doença “tarkat” pode ser associada à lepra (hanseníase). Tendo em mente a análise dos jogos eletrônicos como fonte histórica, alinhada à História das Ciências, especialmente no debate sobre as representações sociais das doenças, pretende-se examinar como a narrativa do personagem Baraka foi construída para abordar questões morais e físicas relacionadas à compreensão da doença e do doente na imaginação social. Quando o texto foca na História Pública, a relação entre doença e empatia aparece em discussões entre usuários em plataformas de redes sociais, como Reddit e YouTube. A seção final do texto propõe a transformação do personagem por meio de um enredo no qual a doença reimagina sua história no jogo. Assim, um personagem que anteriormente era visto com repulsa devido à sua deformidade física, ao ser reimaginada como vítima de uma doença degenerativa e fatal, provoca sensibilidade e uma reinterpretação de sua personalidade.