bluuebunny/crossref_metadata_2025_split huggingface dataset:
Autobiographical memory for the differential diagnosis of cognitive pathology in aging
Authors: Meléndez Juan C , Redondo Rita , Torres Marta , Mayordomo Teresa , Sales Alicia 
Published: October 2015

AimThe present study distinguishes three memory stages across the lifespan, and aims to compare episodic and semantic autobiographical memory in healthy older adults, with amnesic mild cognitive impairment, and withAlzheimer's disease. This information can offer evidence about the way semantic and episodic autobiographical memory work, and how the disease affects them.MethodsThe sample was composed of 56 people, all aged over 60 years; 15 with amnestic mild cognitive impairment, 12 withAlzheimer's disease and 29 healthy older people. Participants were evaluated with the Autobiographical Memory Interview.ResultsA mixedanovashowed significant main effects of memory and time‐period, and significant interactions of memory × group, time‐period × group and memory × time × group.DiscussionAssessment of autobiographical memory provides information to differentiate amnestic mild cognitive impairment patients fromAlzheimer's disease patients. Although the decline in episodic memory starts with the onset of the disease, semantic memory is maintained until moderate stages of dementia.Geriatr Gerontol Int 2016; 16:1220–1225.
Dimensions of stereotypical attitudes among older adults: Analysis of two countries
Authors: Helmes Edward , Pachana Nancy A 
Published: October 2015

AimMuch research on attitudes towards older adults has used younger adults as participants and identified a range of negative attitudes towards older persons. Comparatively little literature has explored the attitudes of older adults themselves towards their own age cohort.MethodsThe present study explicitly compared attitudes towards other older adults from samples of 195 older adults inAustralia and 172 olderCanadians. Attitudinal measures included theAgingAttitudesQuestionnaire (assesses older adults' attitudes toward other older adults),FraboniScale ofAgeism (assesses younger adults' attitudes toward older adults) and theReactions toAgingQuestionnaire (assesses attitudes toward one's own aging), as well as a scale measuring knowledge of aging, theFacts onAgingQuiz, adapted forAustralia andCanada. Responses on the three attitudinal measures were subjected to principal components analysis.ResultsTwo components emerged in both samples, one defined by theReactions toAgingQuestionnaire andAgingAttitudesQuestionnaire scales and the second by theFraboniScale ofAgeism scales. Regression analyses to ascertain prediction of scores on theFacts onAgingQuiz, adapted forAustralia andFacts onAgingQuiz, adapted forCanada showed that only theAgingAttitudesQuestionnaire scale forPhysicalChanges predicted scores on theFacts onAgingQuiz, adapted forAustralia and no attitudes predictedFacts onAgingQuiz, adapted forCanada scores.ConclusionsIt appears that older adults distinguish between their own aging and aging in others. Knowledge of aging appears to be predicted only by attitudes toward physical changes. Given increasing proportions of older adults in the population, as well as increasing access to aging information available to older cohorts, continued research on how older adults view themselves and the aging process is important, and will almost certainly continue to evolve over time.Geriatr Gerontol Int 2016; 16: 1226–1230.
Favorable outcomes in octogenarians treated with bioresorbable polymer drug‐eluting stent
Authors: Ilic Ivan , Stankovic Ivan , Ilisic Bojan , Cerovic Milivoje , Aleksic Aleksandar , Nikolajevic Ivica , Kafedzic Srdjan , Cuellas Ramon Carlos , Sokolov Maxim , El Setecha Mohamed , Putnikovic Biljana , Neskovic Aleksandar N 
Published: October 2015

AimAs a result of a higher prevalence of comorbidities, elderly adults are often underrepresented in clinical trials, and more often experience complications during percutaneous coronary intervention. Our aim was to evaluate clinical outcomes of patients older than 80 years, compared with their younger counterparts, when bioresorbable polymer biolimus A9 drug‐eluting stent is used for their treatment.MethodsThe prospective, observational e‐Nobori registry was created to validate the safety and efficacy of bioresorbable polymer drug‐eluting stent in unselected patients. The primary end‐point of the study was freedom from target lesion failure defined as a composite of cardiac death, target vessel‐related myocardial infarction and clinically‐driven target lesion revascularization at 1 year.ResultsThere were 781 (7.8%) octogenarians, they were less frequently male (62% vs 77%; P < 0.0001) and more often presented as acute coronary syndrome (44% vs 39%; P = 0.0182). The index percutaneous coronary intervention success was lower in the elderly patients (98% vs 99%; P = 0.0398). One‐year follow up was completed for 97% of the elderly patients and 99% of the younger patients. The difference in target lesion failure (3.33% vs 2.83%; log–rank P = 0.0114) was mainly driven by increased mortality in octogenarians (3.73% vs 1.47%; P < 0.0001). Elderly patients had more bleeding and vascular complications (2.67% vs 1.05%; P = 0.0001).ConclusionsDespite advanced age, multiple comorbidities and complexity of treated lesions, clinical outcomes are favorable in octogenarians treated by bioresorbable polymer biolimus A9 drug‐eluting stent. Geriatr Gerontol Int 2016; 16: 1246–1253.
Injury and medical expenditure in emergency department visits of older veterans
Authors: Wang Fu‐Ting , Chang Yuhsuan , Chien Wu‐Chien , Li Hung‐Hui 
Published: October 2015

AimThe purpose of the present study was to investigate the injury types and medical utilization profiles of veterans in emergency department visits by using big data from the National Health Insurance program in Taiwan.MethodWe used the outpatient prescriptions and treatment records between 1997 and 2010 of veterans aged ≥65 years in the National Health Insurance Research Database. The International Classification of Diseases, Ninth Revision, Clinical Modification codes 800–999 (i.e. injuries) were selected, and the emergency medical treatment and the medical institutions' basic profile were recorded.ResultsA total of 287 113 veterans were selected for this study. The average age was 77.4 years, and most participants were men (71.2%). The total medical expenses were US$46.0 million (an average of US$160.00 per person). Contusions/abrasions, open wounds, and fractures comprised 29.2%, 26.6% and 16.3% of the injuries, respectively. In addition, contusions/abrasions, open wounds, and fractures comprised 23.8%, 21.5% and 19.8%, respectively, of the total medical expenses. The highest charges for a single injury episode were for spinal cord and nerve injuries (an average of US$349.00 per person). Regarding sex differences, women mainly experienced fractures and contusions/abrasions, whereas men experienced open wounds.ConclusionsThe injury rate of veterans was reported higher than the non‐veterans. Preventive methods are proposed to decrease the occurrences of injury, number of emergency visits and medical expenses. Geriatr Gerontol Int 2016; 16: 1254–1262.
New Negroes on Campus: St. Clair Drake and the Culture of Education, Reform, and Rebellion at Hampton Institute
Authors: Rosa Andrew J. 
Published: October 2015

As the New Century began… more blacks and whites than ever before had lost faith in one another… The South, everyone could see, had changed enormously over the last quarter century. Everyone could see, too, that the new order came with heavy costs. Edward AyersThe Negro race needs colleges. We need them today as never before; but we do not need colleges so much that we can sacrifice the manhood and womanhood of our children to the thoughtlessness of the North or the prejudice of the South. W. E. B. Du BoisMy experiences as a student at Hampton Institute in Virginia moved me to want to study, understand, and change the odd world of Jim Crow. St. Clair Drake.
Risk factors and common contact allergens in facial allergic contact dermatitis patients
Authors: Kasemsarn Pranee , Iamphonrat Thanawan , Boonchai Waranya 
Published: October 2015

AbstractBackgroundFacial dermatitis is commonly encountered in dermatologic practice. It is sometimes difficult to manage because its causative factors may be multiple and difficult to diagnose.ObjectivesThis study was designed to identify the characteristics, patch test results, and final diagnoses of facial dermatitis patients who were referred to a contact dermatitis clinic and to identify factors associated with facial allergic contact dermatitis (ACD).MethodsWe retrospectively reviewed case records of facial dermatitis patients who underwent patch testing at the clinic during the period from July 2006 to June 2011.ResultsOf the 891 patients patch‐tested, 244 (27.4%) had facial dermatitis. Female patients were 9.1 times more predominant than male patients. The mean ± standard deviation age of patients was 37.3 ± 14.8 years. A total of 199 (81.6%) patients demonstrated at least one positive reaction to a patch test, 66.7% of which were clinically relevant. Allergic contact dermatitis was diagnosed in 45.5% of patients. Independent factors predisposing towards facial dermatitis were female sex, having a previous history of cosmetic allergy, a positive patch test reaction to hairdressing product‐related allergens, and a positive allergic reaction to preservative allergens.ConclusionsThe prevalence of facial dermatitis was 27.4%. Almost half of all patients with facial dermatitis demonstrated ACD. Factors associated with facial ACD were female gender, a history of cosmetic allergy, and positive patch test reactions to hairdressing product‐related allergens and preservatives.
Dermoscopic features of acral pigmented lesions in Egyptian patients: a descriptive study
Authors: Elwan Nagwa M. , Eltatawy Rania A. , Elfar Nashwa N. , Elsakka Omnia M. 
Published: October 2015

AbstractBackgroundDermoscopy is a non‐invasive technique allowing rapid and magnified in vivo observation of the skin. The anatomical structure of acral volar skin results in unique dermoscopic features in this location.ObjectiveTo describe and analyze the characteristic dermoscopic features of various kinds of acral pigmented lesions and emphasize the diagnostic value of the dermoscope in early melanoma at this anatomic site in a sample of Egyptians.Patients and methodsThis study included 200 patients with 224 acral pigmented lesions. Dermoscopic examination was done to evaluate different dermoscopic patterns of these lesions. Clinically and dermoscopically suspicious lesions for malignancy were selected for more evaluation by histopathological examination by hematoxylin–eosin staining.ResultsThe most frequent dermoscopic pattern was the parallel furrow pattern, (66.1%), followed by the lattice‐like (8.9%), homogeneous (7.6%), fibrillar (6.3%), non‐typical (5.4%), and then parallel ridge (2.2%). The least commonly reported patterns in our cases were the reticular and globular patterns (1.8% each). There was one case of acral lentiginous melanoma of the palm with a multicomponent dermoscopic pattern.ConclusionThe recognition of different dermoscopic patterns is essential for diagnosis of various types of acral pigmented lesions. In addition, dermoscopy is useful in discriminating between acral nevi and early acral melanoma and narrows down the number of biopsies needed.
Missional Church: A Historical and Theological Analysis of an Ecclesiological Tradition
Authors: Nikolajsen Jeppe Bach 
Published: October 2015

AbstractThis article argues that an understanding of the development of a missional ecclesiology requires we recognize three closely connected and significant matters in 20th‐century mission history: first, the increasing appreciation of the interconnection of church and mission evinced at major ecumenical conferences in the mid‐20th century; second, the contributions of influential missiologistLesslieNewbigin and his theological integration of mission and church; and third, the breakthrough of the phrase “missional church” with the 1998 publication of the bookMissional Church. This article traces this three‐part development through both historical and theological analyses.
Self‐reported antenatal adherence to medical treatment among pregnant women with Crohn’s disease
Authors: Nielsen M. J. , Nørgaard M. , Holland‐Fisher P. , Christensen L. A. 
Published: October 2015

Aliment Pharmacol Ther 2010; 32: 49–58SummaryBackground  Adherence to medical treatment among women with Crohn’s disease (CD) prior to and during pregnancy has never been reported.Aim  To examine both the predictors and prevalence rates of non‐adherence to maintenance medical treatment among women with CD prior to and during pregnancyMethods  Among a population of 1.6 million inhabitants, we identified a total of 132 women with CD who had given birth during 2000–2005. Questionnaires were used to investigate predictors and extent of adherence. The validity of self‐reported use of medication was assessed using data from the Danish Prescription Database. We used logistic regression to estimate prevalence odds ratios for non‐adherence according to smoking status and other predictors.Results  Eighty percent of the patients returned the questionnaire. A total of 58 (54%) women reported to have been on medical treatment, 50 of whom had fulfilled a prescription on relevant medication. Adherence to medical treatment was 72%. Fear of a negative effect on fertility/foetus was a reason for non‐adherence by 18.8% prior to, and by 45.5% during, pregnancy. Among smokers, 30.8% were non‐adherent compared with 11.5% among nonsmokers (prevalence odds ratio 3.41, 95% CI 0.8–14.7).Conclusions  Despite fear of a negative effect on fertility/foetus, adherence to medical treatment is high in women with CD. There is no substantial variation in adherence prior to and during pregnancy. Smoking prior to pregnancy is a predictor of non‐adherence.
Expanding the role of umbilical cord blood transplantation
Authors: Brunstein Claudio G. , Setubal Daniela C. , Wagner John E. 
Published: October 2015

SummaryUmbilical cord blood has become a valuable alternative source of haematopoietic stem cells for allogeneic transplantation. However, largely because of the impact of cell dose on engraftment, risk of transplant‐related mortality and survival, progress in the field has been largely restricted to children. Nevertheless, substantial clinical experience with umbilical cord blood transplantation clearly establishes its safety and effectiveness in young patients with a variety of malignant and non‐malignant diseases. Although less well established in adults, new strategies are now being explored to address the obstacle of cell dose. This article reviews the state of the art and future directions with umbilical cord blood as a source of haematopoietic stem cells for transplantation in both children and adults.
Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasion
Authors: Salama Paul , Phillips Michael , Platell Cameron , Iacopetta Barry 
Published: October 2015

Salama P, Phillips M, Platell C & Iacopetta B (2011) Histopathology59, 207–215Low expression of Granzyme B in colorectal cancer is associated with signs of early metastastic invasionAims:  Tumour‐infiltrating forkhead box P3 (FoxP3+) regulatory T cells (Tregs) have stronger prognostic significance than cytotoxic CD8+ T cells in colorectal cancer (CRC). Because there is evidence that some tumour‐infiltrating CD8+ T cells may be inactive, the present study aimed to investigate the prognostic significance of Granzyme B, one of the major effector molecules of T cells.Methods and results:  A tissue microarray containing 963 CRCs was stained immunohistochemically for Granzyme B and the level of expression quantified by digital image analysis. Granzyme B expression was higher in tumours with microsatellite instability (P < 0.0001), a dense lymphocytic infiltrate (P < 0.0001) and location in the proximal colon (P = 0.009), but lower in tumours with vascular invasion (P = 0.007), perineural invasion (P =0.041) and positive nodal status (P < 0.001). Elevated expression of Granzyme B was associated with improved survival on univariate analysis (hazard ratio = 0.65; 95% confidence interval 0.51–0.84; P = 0.001), but not in a multivariate model that included stage, vascular invasion and FoxP3+ Treg cell density.Conclusions:  Low expression of Granzyme B was associated with early signs of metastasis in CRC. The stronger prognostic significance of FoxP3+ Tregs is in keeping with animal models that suggest these cells act as gatekeepers for the release of Granzyme B from CD8+ T cells.
Loss of dystroglycan function in oesophageal cancer
Authors: Parberry‐Clark Charlotte , Bury Jonathan P , Cross Simon S , Winder Steve J 
Published: October 2015

Parberry‐Clark C, Bury J P, Cross S S & Winder S J  (2011) Histopathology59, 180–187Loss of dystroglycan function in oesophageal cancerAims:  Oesophageal cancer is an increasingly common human malignancy, with its incidence in the West rapidly rising. It is associated with a very poor prognosis, and its exact pathogenesis is uncertain. Dystroglycan and E‐cadherin are cell adhesion molecules, the loss of which is often related to tumour differentiation, aggressiveness and invasiveness. The aim was therefore to evaluate their roles in oesophageal carcinogenesis.Methods and results:  mRNA and protein levels of dystroglycan and E‐cadherin were examined in oesophageal normal and tumour tissue samples, and in FLO‐1 oesophageal adenocarcinoma cells, using immunohistochemistry, western blotting and reverse transcription polymerase chain reaction. E‐cadherin,α‐dystroglycan and β‐dystroglycan levels were decreased in the oesophageal primary tumour samples, despite the presence of normal levels of dystroglycan mRNA. In FLO‐1 cells, increasing cell density caused a decrease in protein levels of β‐dystroglycan over time, despite the persistent presence of dystroglycan mRNA. Re‐expression of dystroglycan in FLO‐1 cells reduced the numbers and size of colonies formed in soft agar, indicative of a role for dystroglycan in suppressing the tumour phenotype.Conclusions:  The adenocarcinoma cells mirrored the in vivo situation with respect to dystroglycan function, making this a useful model of oesophageal carcinogenesis; moreover, loss of dystroglycan protein, despite the presence of dystroglycan mRNA, points to a post‐translational mechanism of dystroglycan loss.
No non‐sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load
Authors: Bogenrieder Thomas , van Dijk Marijke R , Blokx Willeke A M , Ramrath Katrin , Seldenrijk Kees , Stolz Wilhelm , van Diest Paul J 
Published: October 2015

Bogenrieder T, van Dijk M R, Blokx W A M, Ramrath K, Seldenrijk K, Stolz W & van Diest P J (2011) Histopathology59, 318–326No non‐sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour loadAims:  Most melanoma patients with a positive sentinel node (SN) undergo completion lymph node dissection and frequently experience associated morbidity. However, only 10–30% of SN‐positive patients have further lymph node metastases. The aim of the present study was to predict the absence of non‐SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load.Methods and results:  Of 70 SN positive patients, 18 had non‐SN metastases. Penetrative depth of metastatic cells into the SN and SN tumour load was assessed by morphometry. None of the 14 patients (20%) with a Breslow thickness <2.0 mm and an SN tumour load <0.2 mm2 had non‐SN metastases. Similarly, none of the 15 patients (21%) with a Breslow thickness <2.0 mm and SN penetrative depth <600 μm had non‐SN metastases. Lastly, none of the 14 patients (20%) with a Breslow thickness <2.0 mm and a diameter of the largest SN deposit <500 μm had non‐SN metastases.Conclusions:  A combination of limited Breslow thickness and low SN tumour load predicts absence of non‐SN metastases in melanoma patients with a positive SN with high accuracy. We propose that this subgroup may be spared completion lymph node dissection.
Analysis of miR‐376 RNA cluster members in the mouse inner ear
Authors: Yan Denise , Xing Yazhi , Ouyang Xiaomei , Zhu Juhong , Chen Zheng‐yi , Lang Hainan , Liu Xue Z. 
Published: October 2015

SummaryMutations in phosphoribosyl pyrophosphate synthetase 1 (PRPS1) are associated with a spectrum of non‐syndromic to syndromic hearing loss. PRPS1 transcript levels have been shown to be regulated by the microRNA‐376 genes. The long primary RNA transcript of the miR‐376 RNA cluster members undergo extensive and simultaneous A → I editing at one or both of two specific sites (+4 and +44) in particular human and mouse tissues. The PRPS1 gene, which contains target sites for the edited version of miR‐376a‐5p within its 3′UTR, has been shown to be repressed in a tissue‐specific manner. To investigate whether the transcription of Prps1 is regulated by miR‐376 cluster members in the mouse inner ear, we first quantified the expression of the mature miR‐376 RNAs by quantitative real‐time‐PCR. The spatio‐temporal patterns of miR‐376 expression were assessed by in situ hybridization. Finally, we examined whether A →I editing of pri‐miR‐376 RNAs occurs in mouse inner ear by direct sequencing. Our data showed that the miR‐376a‐3p, b‐3p, c‐3p are present in mouse embryonic inner ears and intensive expression of miR‐376a‐3p/b‐3p was detected in the sensory epithelia and ganglia of both auditory and vestibular portions of the inner ear. In adult inner ear, the expression of miR‐376a‐3p/b‐3p is restricted within ganglion neurons of auditory and vestibular systems as well as the cells in the stria vascularis. Only unedited pri‐miR‐376 RNAs were detected in the cochlea suggesting that the activity of PRPS1 in the inner ear may not be regulated through the editing of miR‐376 cluster.