bluuebunny/crossref_metadata_2025_split huggingface dataset:
Libération provisoire de la parole en prison. L'expérience d'un groupe de parole thérapeutique pour les auteurs d'agressions sexuelles
Authors: Réveillaud Marie , Godet Christine , Smaniotto Barbara , Guyod Fabrice 
Published: June 2013

En application des recommandations de la Conférence de Consensus (2002) relative aux traitements des auteurs d’agressions sexuelles ( AVS ), nous avons mis en œuvre des groupes de parole pour des AVS incarcérés en maison d’arrêt. La description du dispositif et l’étude d’un cas clinique nous permettront de porter l’accent sur le processus qui permet, après une période de déni, d’approcher plus en détail l’acte commis, d’aborder sa place dans l’histoire du sujet et d’évoquer la victime sur un mode moins « persécutoire ». Nous mettrons en évidence l’importance des failles narcissiques, que compense l’enveloppe groupale, et le repérage des facteurs de vulnérabilité déclenchant le passage à l’acte. Ce travail entre dans le cadre de la prévention de la récidive des violences sexuelles et a pour ambition de rendre possible pour les participants de ce groupe l’amorce d’un travail psychothérapeutique à long terme.
Le pícaro, héros en tension et figure de la rupture
Authors: Bertin-Élisabeth Cécile 
Published: June 2013

Avec un protagoniste aux origines viles, héros de la marge, les récits picaresques nous invitent à repenser l’héroïcité et à interroger diverses tensions et ruptures, tant du point de vue du fond que de la forme. Devons-nous alors, comme le fait communément la critique, entériner le déterminisme de ces récits et faire fi de leur dimension prospective, utopique, et présenter les pícaros comme des anti-héros dont les échecs successifs confirmeraient l’ordre pré-établi de la société classique espagnole ? En somme, le pícaro est-il une figure de la norme ou une figure de la rupture, de la rupture-brèche ou bien de la rupture-fracture ? Induit-il une transgression ou plutôt une subversion ? Et y parvient-il par le biais du détour ou de manière frontale ? Dans ce conflit idéologique ou « tectonique des idéologies », le cas du Buscón s’individualise par sa double tension.
Contra lo justo : l’Arte nuevo de hacer comedias (1609) ou l’invention de la liberté
Authors: Torres Milagros 
Published: June 2013

Ce travail explore la notion de gusto, en tant que pilier de la nouveauté qui apparaît dans Arte nuevo de hacer comedias en este tiempo (1609). Prenant sa source chez Aristote, un esprit subtil de liberté, après avoir conquis les corrales, inspire l’ouvrage théorique de Lope. Le corps y joue un rôle essentiel : une esthétique gestuelle novatrice, des jeux visuels et auditifs, une image corporelle audacieuse qui explore l’imaginaire sensoriel et érotique, une nouvelle intelligence de la scène, osée et prudente à la fois, soumise à l’empire de la fantaisie.
Ruptures et revendication d’être dans la poésie de Gioconda Belli
Authors: Besse Nathalie 
Published: June 2013

Les poésies de la Nicaraguayenne Gioconda Belli (1948-…) célèbrent et prolongent diverses formes de révolutions liées entre elles : une révolution féministe, sexuelle et sociale. Nous verrons en quoi elle a pu bousculer les normes sociales du Nicaragua des années 1970 et comment, au gré de ces diverses transgressions, Gioconda Belli est ou libère ce qu’elle est : ou de la rupture comme possible révélation de soi.
Rupture et comédie du remariage dans La vida conyugal de Sergio Pitol
Authors: Estève Raphaël 
Published: June 2013

La première rupture mise en scène dans La vida conyugal de Sergio Pitol (1991) est bien entendu celle opérée vis-à-vis de l’institution matrimoniale, dont les attendus contractuels sont minés par la parodie. Mais, par devers les entorses répétées de l’épouse, Jacqueline Cascorro, une dimension plus ontologique se fait jour. Les transgressions opérées à l’encontre de la « raison » sociale par l’héroïne problématisent en effet la reconnaissance du conjoint, Nicolás Lobato. Le fait que la reconnaissance de l’altérité de ce dernier passe par une acceptation de l’ordinaire – avec lequel le personnage féminin est également en rupture – a imposé ici le recours au cadre conceptuel forgé par le philosophe Stanley Cavell dans son étude des « comédies du remariage », grâce à quoi il est possible de penser, dans le roman de Pitol, le problème de l’expression ainsi que les termes de la séparation, du tragique et du burlesque.
La Culture rock entre utopie moderniste et construction d’une industrie alternative
Authors: Tandt Christophe Den 
Published: June 2013

Cet article analyse la musique rock comme une pratique visant une transfiguration utopienne du quotidien. Invoquant les réflexions de Fredric Jameson et Ihab Hassan sur le (post)modernisme, l’argument situe la musique rock parmi les mouvements de la modernité qui cherchent à contrer l’aliénation et la réification. A partir de cette prémisse, l’article évalue l’impact que le rock a exercé sur les pratiques culturelles et sociales — un impact qui par définition ne peut remplir les promesses du projet initial. Cette approche révèle que la dynamique utopienne du rock a eu comme conséquence résiduelle le développement de ce que Pierre Bourdieu appelle un champ de production restreinte : musiciens, fans et journalistes ont défini les pratiques permettant de tracer un périmètre d’autonomie artistique séparant le rock de domaines commerciaux de la culture de masse. Ensuite, l’article s’intéresse à un aspect spécifique du processus qui mène de l’utopie à sa concrétisation sociale : il décrit le rôle joué par le rock dans la représentation de formes de travail qui échappent à l’aliénation de la vie professionnelle. Dans cette optique, le rock a offert une représentation valorisée du travail musical qui permet une critique des rôles imposés par le marché capitaliste.
“Fear and Wonder”. Le fantastique sombre et l'harmonie des médiantes, de Hollywood au black metal
Authors: Hainaut Bérenger 
Published: June 2013

Né au début des années 1990 en Norvège, le style black metal se caractérise notamment par l'utilisation d'enchaînements d'accords mineurs à distance de tierce, liés à l'harmonie des médiantes. Issues du romantisme européen, ces progressions harmoniques ont ensuite largement irrigué les musiques symphoniques des films du xxe siècle. Le renouveau symphonique qui intervient à Hollywood autour de John Williams à partir des années 1970 remet ces codes à l'ordre du jour et cristallise l'association des enchaînements décrits avec un contexte « fantastique sombre », versant « maléfique » des films fantastiques dans lesquels on les trouve. Ce lien permet de saisir ce qui a poussé les compositeurs du black metal à utiliser ces enchaînements : ces derniers, liés à quelque chose de « malsain », entrent en résonance avec le projet artistique du black metal.
Scream from the Heart: Yoko Ono’s Rock and Roll Revolution
Authors: Brown Shelina 
Published: June 2013

Alors que la majorité de la littérature universitaire traitant de Yoko Ono se concentre sur son rôle pionnier en tant qu’artiste conceptuelle et performeuse, peu de recherches ont porté sur ce qu’elle a accompli en tant que chanteuse rock expérimentale. Dans cet article, je traiterai de la virulence de son expression vocale – ses cris – en tant qu’exemples politiquement signifiants d’un art sonore abject, situés dans le contexte sociopolitique tumultueux de la contre-culture américaine des années 1960. À partir de l’analyse de ses performances vocales sur les albums Yoko Ono: Plastic Ono Band (1970) et Fly (1971), l’élan révolutionnaire d’Ono – son « cri du cœur » – sera considéré comme un geste de redéfinition de l’expression musicale par des processus genrés d’abjection et de résistance culturelle. Ce chant extrême sera considéré comme une réponse viscérale aux mouvements politiques et aux pratiques de la contre-culture. En partant de l’affirmation de Tamara Levitz selon laquelle la puissance du cri de Yoko Ono tient à l’évocation violente et discordante d’une intense immédiateté corporelle, je souhaite défendre l’idée que cette « immédiateté corporelle », produite par son « cri », est également liée à un processus paradoxal d’abjection corporelle. Dans le contexte des performances vocales extrêmes de cette artiste, le cri fonctionne en effet comme un acte d’abjection sonore, et met en évidence un corps marginalisé qui négocie et défie ses propres frontières liminales au sein d’une formation sociopolitique plus large.
Both NK Cell–Intrinsic and –Extrinsic STAT1 Signaling Are Required for NK Cell Response against Vaccinia Virus
Authors: Fortin Carl , Huang Xiaopei , Yang Yiping 
Published: June 2013

Abstract
NK cells play an important role in innate immune control of the infection with vaccinia virus (VV). However, it remains incompletely defined how the activation of NK cells in response to VV is regulated. In this study, we showed that STAT1 was critical for NK cell activation upon VV infection and the subsequent clearance of VV infection in vivo. We further demonstrated that STAT1 signaling in both NK and accessory cells such as dendritic cells was required for efficient NK cell activation upon VV infection. Mechanistically, STAT1 signaling in dendritic cells promoted the expression of NKG2D ligands, which is required for NK cell activation via the NKG2D pathway. Taken together, our data suggest that STAT1 mediates anti-VV effect by promoting NK cell activation through both NK-intrinsic and extrinsic mechanisms and may provide insights into the design of effective NK cell–based therapies for viral infections.
Structural Evaluation of a Mimicry-Recognizing Paratope: Plasticity in Antigen–Antibody Interactions Manifests in Molecular Mimicry
Authors: Tapryal Suman , Gaur Vineet , Kaur Kanwal J. , Salunke Dinakar M. 
Published: June 2013

Abstract
Molecular mimicry manifests antagonistically with respect to the specificity of immune recognition. However, it often occurs because different Ags share surface topologies in terms of shape or chemical nature. It also occurs when a flexible paratope accommodates dissimilar Ags by adjusting structural features according to the antigenic epitopes or differential positioning in the Ag combining site. Toward deciphering the structural basis of molecular mimicry, mAb 2D10 was isolated from a maturing immune response elicited against methyl α-d-mannopyranoside and also bound equivalently to a dodecapeptide. The physicochemical evidence of this carbohydrate–peptide mimicry in the case of mAb 2D10 had been established earlier. These studies had strongly suggested direct involvement of a flexible paratope in the observed mimicry. Surprisingly, comparison of the Ag-free structure of single-chain variable fragment 2D10 with those bound to sugar and peptide Ags revealed a conformationally invariant state of the Ab while binding to chemically and structurally disparate Ags. This equivalent binding of the two dissimilar Ags was through mutually independent interactions, demonstrating functional equivalence in the absence of structural correlation. Thus, existence of a multispecific, mature Ab in the secondary immune response was evident, as was the plasticity in the interactions while accommodating topologically diverse Ags. Although our data highlight the structural basis of receptor multispecificity, they also illustrate mechanisms adopted by the immune system to neutralize the escape mutants generated during pathogenic insult.
Naturally Occurring ERAP1 Haplotypes Encode Functionally Distinct Alleles with Fine Substrate Specificity
Authors: Reeves Emma , Edwards Christopher J. , Elliott Tim , James Edward 
Published: June 2013

Abstract
Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims peptides for MHC class I presentation, influencing the degree and specificity of CD8+ T cell responses. Single-nucleotide polymorphisms within the exons encoding ERAP1 are associated with autoimmune diseases and cervical carcinoma, but it is not known whether they act independently or as disease-associated haplotypes. We sequenced ERAP1 from 20 individuals and show that single-nucleotide polymorphisms occur as distinct haplotypes in the human population and that these haplotypes encode functionally distinct ERAP1 alleles. Using a wide range of substrates, we are able to demonstrate that for any given substrate distinct ERAP1 alleles can be “normal,” “hypofunctional,” or “hyperfunctional” and that each allele has a trend bias toward one of these three activities. Thus, the repertoire of peptides presented at the cell surface for recognition by CTL is likely to depend on the precise combination of both MHC class I and ERAP1 alleles expressed within an individual, and has important implications for predisposition to disease.
Real Hypersurfaces in Complex Two-Plane Grassmannians with Reeb Parallel Structure Jacobi Operator
Authors: Jeong Imsoon , Kim Seonhui , Jin Suh Young 
Published: June 2013

AbstractIn this paper we give a characterization of a real hypersurface of Type (A) in complex two-plane GrassmanniansG2(ℂm+2), which means a tube over a totally geodesicG2(ℂm+1) inG2(ℂm+2), by means of the Reeb parallel structure Jacobi operator ∇εRε= 0.
The Lived Experience of Diagnosis Delivery in Motor Neurone Disease: A Sociological-Phenomenological Study
Authors: Pavey Amanda , Allen-Collinson Jacquelyn , Pavey Toby 
Published: June 2013

Relatively few previous studies of individuals receiving a diagnosis of Motor Neurone Disease within the UK health care system have employed qualitative approaches to examine the diagnostic journey from a patient perspective. A qualitative sociological study was undertaken, involving interviews with 42 participants diagnosed with MND, to provide insight into their experiences of undergoing testing and receiving a diagnosis. Adopting a sociological-phenomenological perspective, this article examines key themes that emerged from participant accounts surrounding the lived experience of the diagnostic journey. The key themes that emerged were: The diagnostic quest; living with uncertainty; hearing bad news; communication difficulties; and a reified body of medical interest. In general, doctor-patient communication both at pre and post diagnosis was experienced as highly stressful, distressing and profoundly upsetting. Participants reported such distress as being due to the mode of delivery and communication strategies used by health professionals. We therefore suggest that professional training needs to emphasize the importance to health professionals of fostering greater levels of tact, sensitivity and empathy towards patients diagnosed with devastating, life-limiting illnesses such as MND.
Regio‐ and Stereospecific Prenylation of Flavonoids by Sophora flavescens Prenyltransferase
Authors: Chen Ridao , Liu Xiao , Zou Jianhua , Yin Yunze , Ou Bin , Li Jianhua , Wang Ruishan , Xie Dan , Zhang Peicheng , Dai Jungui 
Published: June 2013

AbstractPrenylflavonoids are valuable natural products that are widely distributed in plants. They often possess divergent biological properties, including phytoestrogenic, anti‐bacterial, anti‐tumor, and anti‐diabetic activities. The reaction catalyzed by prenyltransferases represents a Friedel–Crafts alkylation of the flavonoid skeleton in the biosynthesis of natural prenylflavonoids and often contributes to the structural diversity and biological activity of these compounds. However, only a few plant flavonoid prenyltransferases have been identified thus far, and these prenyltransferases exhibit strict substrate specificity and low catalytic efficiency. In this article, a flavonoid prenyltransferase from Sophora flavescens, SfFPT, has been identified that displays high catalytic efficiency with high regiospecificity acting on C‐8 of structurally different types of flavonoid (i.e., flavanone, flavone, flavanonol, and dihydrochalcone, etc.). Furthermore, SfPFT exhibits strict stereospecificity for levorotatory flavanones to produce (2S)‐prenylflavanones. This study is the first to demonstrate the substrate promiscuity and stereospecificity of a plant flavonoid prenyltransferase in vitro. Given its substrate promiscuity and high catalytic efficiency, SfFPT can be used as an environmentally friendly and efficient biological catalyst for the regio‐ and stereospecific prenylation of flavonoids to produce bioactive compounds for potential therapeutic applications.
Tetraalkynylated and Tetraalkenylated Benzenes and Pyridines: Synthesis and Photophysical Properties
Authors: Ehlers Peter , Hakobyan Ani , Neubauer Antje , Lochbrunner Stefan , Langer Peter 
Published: June 2013

AbstractTetra(arylalkynyl)pyridines and tetra(arylalkenyl)pyridines and their benzene analogues were prepared by palladium‐catalyzed cross‐coupling reactions from the commercially available chlorinated substrates in good to excellent yields. The photophysical properties of selected compounds were investigated and compared to each other. Very good fluorescence quantum yields were observed, especially for the pyridine derivatives.
Gold Catalysis: β‐Ketonaphthalenes via Molecular Gymnastics of 1,6‐Diyne‐4‐en‐3‐ols
Authors: Lauterbach Tobias , Arndt Sebastian , Rudolph Matthias , Rominger Frank , Hashmi A. Stephen K. 
Published: June 2013

Abstract1,6‐Diyne‐4‐en‐3‐ols with one terminal alkyne were applied as test substrates for a possible dual catalyzed cyclization. Instead of a dual catalysis cycle, naphthyl ketone derivatives were obtained as single products. The regioselectivity of the obtained products is unprecedented. Instead of the expected naphthyl ketones bearing the keto group in the α‐position, the keto group is positioned in the ß‐position of the naphthyl skeleton by a complex rearrangement of the starting materials.
A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems
Authors: Groen‐Blokhuis Maria M. , Franić S. , van Beijsterveldt Catharina E.M. , de Geus Eco , Bartels Meike , Davies Gareth E. , Ehli Erik A. , Xiao Xiangjun , Scheet Paul A. , Althoff Robert , Hudziak James J. , Middeldorp Christel M. , Boomsma Dorret I. 
Published: June 2013

AbstractBreastfeeding has been associated with improved cognitive functioning. There is a beneficial effect on IQ, and possibly on associated phenotypes such as attention problems. It has been suggested that the effect on IQ is moderated by polymorphisms in the FADS2 gene, which is involved in fatty acid metabolism. In this study we tested the relation between breastfeeding and FADS2 polymorphisms on the one hand and IQ, educational attainment, overactivity, and attention problems on the other hand. IQ at age 5, 7, 10, 12, and/or 18 (n = 1,313), educational attainment at age 12 (n = 1,857), overactive behavior at age 3 (n = 2,560), and attention problems assessed at age 7, 10, and 12 years (n = 2,479, n = 2,423, n = 2,226) were predicted by breastfeeding and two SNPs in FADS2 (rs174575 and rs1535). Analyses were performed using structural equation modeling. After correction for maternal education, a main effect of breastfeeding was found for educational attainment at age 12 and overactive behavior at age 3. For IQ, the effect of breastfeeding across age was marginally significant (P = 0.05) and amounted to 1.6 points after correcting for maternal education. Neither a main effect of the FADS2 polymorphisms nor an interaction with breastfeeding was detected for any of the phenotypes. This developmentally informed study confirms that breastfeeding is associated with higher educational attainment at age 12, less overactive behavior at age 3 and a trend toward higher IQ after correction for maternal education. In general, the benefits of breastfeeding were small and did not interact with SNPs in FADS2. © 2013 Wiley Periodicals, Inc.
Simulation on temperature distribution of oil palm empty fruit bunches during the microwave pyrolysis process
Authors: Hussain Siti Aslina , Bano Shaista , Yeoh Hooi Sim , Rozita Omar 
Published: June 2013

ABSTRACTOil palm empty fruit bunches (EFB) is a plentiful agricultural waste in Malaysia, which can be further processed to increase its calorific value for fuel purposes and as a value‐added product. Microwave pyrolysis is a promising technology that can convert the EFB into bio‐oil, char and synthesis gas without cracking the EFB surface because of overheating. Computational fluid dynamics (ansysTM cfx 13.0, ANSYS, Inc. Southpointe, 275 Technology Drive, Canonsburg, PA 15317, U.S.A.) was used in a 3‐D model to predict the temperature distribution of the EFB model in a microwave‐heated reactor during the pyrolysis process. The parameters under investigation include heating source orientation, nitrogen gas flow rate, microwave power intensity and microwave absorber efficiency, which have an important role in pyrolysis optimisation. The results show that heating source orientation and nitrogen gas flow rate did not affect the EFB temperature profiles. However, microwave power intensity has a linear relationship with the EFB temperature at different microwave absorber efficiencies. © 2013 Curtin University of Technology and John Wiley & Sons, Ltd.
Bio‐ und Geotop Einhornhöhle
Authors: Nielbock Ralf , Röhling Heinz‐Gerd 
Published: June 2013

AbstractZwischen den Städten Herzberg und Bad Lauterberg existiert ein Gebiet aus weißen Gipsgesteinen und schroffen Dolomitklippen, in denen auch die weltberühmte “Einhornhöhle” liegt. Früher wurde hier intensiv nach den angeblich heilkräftigen Einhornknochen gesucht – heute weiß man, dass die Höhle die Heimat von Höhlenbären und vielen anderen Tierarten war – und dass man noch lange nicht alle Geheimnisse der Höhle kennt.
Geruchssinn bei Schmarotzerpflanzen?
Authors: Krause Kirsten 
Published: June 2013

AbstractSchmarotzerpflanzen haben sich auf das Stehlen von Nährstoffen von autotrophen Pflanzen spezialisiert. Jetzt steht fest, dass sie ihre Opfer nicht unbedingt zufällig treffen, sondern dass sie von den flüchtigen Aromastoffen der Pflanzen angelockt werden.
Characterizing the interaction between enantiomers of eight psychoactive drugs and highly sulfated‐β‐cyclodextrin by counter‐current capillary electrophoresis
Authors: Asensi‐Bernardi Lucía , Escuder‐Gilabert Laura , Martín‐Biosca Yolanda , Sagrado Salvador , Medina‐Hernández María José 
Published: June 2013

ABSTRACTThe estimation of apparent binding constants and limit mobilities of the complexes of the enantiomers that characterize the interaction of enantiomers with chiral selectors, in this case highly sulfated β‐cyclodextrin, was approached using a simple and economic electrophoretic modality, the complete filling technique (CFT) in counter‐current mode. The enantiomers of eight psychoactive drugs, four antihistamines (dimethindene, promethazine, orphenadrine and terfenadine) and four antidepressants (bupropion, fluoxetine, nomifensine and viloxazine) were separated for the first time for this cyclodextrin (CD). Estimations of thermodynamic and electrophoretic enantioselectivies were also performed. Results indicate that, in general, thermodynamic enantioselectivity is the main component explaining the high resolution found, but also one case suggests that electrophoretic enantioselectivity itself is enough to obtain a satisfactory resolution. CFT results advantageous compared with conventional capillary electrophoresis (CE) and partial filling technique (PFT) for the study of the interaction between drugs and chiral selectors. It combines the use of a simple fitting model (as in CE), when the enantiomers do not exit the chiral selector plug during the separation (i.e. mobility of electroosmotic flow larger than mobility of CD), and drastic reduction of the consumption (and cost; ~99.7%) of the CD reagent (as in PFT) compared with the conventional CE. Copyright © 2013 John Wiley & Sons, Ltd.