bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory effect of cervical trachea and chest wall vibrations on cough reflex sensitivity and perception of urge-to-cough in healthy male never-smokers
Authors: Kashiwazaki Naohiro , Ebihara Satoru , Gui Peijun , Katayama Norihiro , Ito Kumiko , Sato Ryuhei , Oyama Chika , Ebihara Takae , Kohzuki Masahiro 
Published: October 2013

Abstract

Background
Non-pharmacological options for symptomatic management of cough are desired. Although chest wall mechanical vibration is known to ameliorate cough reflex sensitivity, the effect of mechanical vibrations on perceptions of urge-to-cough has not been studied. Therefore, we investigated the effect of mechanical vibration of cervical trachea, chest wall and femoral muscle on cough reflex sensitivity, perceptions of urge-to-cough as well as dyspnea.

Methods
Twenty-four healthy male never-smokers were investigated for cough reflex sensitivity, perceptions of the urge-to-cough and dyspnea with or without mechanical vibration. Cough reflex sensitivity and urge-to-cough were evaluated by the inhalation of citric acid. The perception of dyspnea was evaluated by Borg scores during applications of external inspiratory resistive loads. Mechanical vibration was applied by placing a vibrating tuning fork on the skin surface of cervical trachea, chest wall and femoral muscle.

Results
Cervical trachea vibration significantly increased cough reflex threshold, as expressed by the lowest concentration of citric acid that elicited five or more coughs (C5), and urge-to-cough threshold, as expressed by the lowest concentration of citric acid that elicited urge-to-cough (Cu), but did not significantly affect dypnea sensation during inspiratory resistive loading. On the other hand, the chest wall vibration not only significantly increased C5 and Cu but also significantly ameliorated the load-response curve of dyspnea sensation.

Conclusions
Both cervical and trachea vibrations significantly inhibited cough reflex sensitivity and perception of urge-to-cough. These vibration techniques might be options for symptomatic cough management.
Pulmonary hypertension secondary to hyperviscosity in a patient with rheumatoid arthritis and acquired von Willebrand disease: a case report
Authors: Hernández-Gilsoul Thierry , Atisha-Fregoso Yemil , Vargas-Ruíz Angel G , Rivero-Sigarroa Eduardo , Dominguez-Cherit Guillermo , Ñamendys-Silva Silvio A 
Published: October 2013

Abstract

Introduction
Acquired von Willebrand disease is initiated by autoantibodies and hyperviscosity syndrome caused by a massive polyclonal hypergammaglobulinemia. Acquired von Willebrand disease associated with autoimmune disease in addition to pulmonary hypertension during emergency room presentation is a rare condition. To the best of our knowledge, this is the second case reported in the literature treated with success; the first one was reported in 1987.

Case presentation
A 28-year-old mestizo man with a 3-year history of inflammatory arthritis was admitted to our hospital. An overlap of rheumatoid arthritis with systemic lupus erythematosus was suspected; therefore methotrexate was initiated, and later changed to leflunomide because of liver toxicity. Prothrombin time, international normalized ratio and activated partial thromboplastin times were normal (11/10.4 seconds; 1.2; 31.1/26.9 seconds, respectively), von Willebrand factor activity was observed with low ristocetin cofactor at 33.6UI/dL, high von Willebrand factor antigen >200UI/dL, and a low von Willebrand factor: ristocetin cofactor to von Willebrand factor antigen ratio. He was admitted to the emergency room with a 24-hour evolution of progressive dyspnea, cough, thoracic pain, and palpitations, 104 beats/min, 60/40 mmHg, temperature of 38°C, pulse oximetric saturation 88% and 30 breaths/minute. Cold, pale and mottled skin was also observed. He was then transferred to the intensive care unit. The placement of a pulmonary artery catheter was made. The initial patterns showed a precapillary pulmonary hypertension; acute pulmonary embolism was the first choice for diagnosis. Pulmonary angiography was conducted, and when no clot was discovered, pulmonary artery hypertension associated with connective tissue disease was considered. Serum protein electrophoresis confirmed the presence of a massive polyclonal hypergammaglobulinemia, and no paraproteinemia or monoclonal cell population was found from the electrophoretic pattern of the patient’s plasma. Hypergammaglobulinemia was the cause of hyperviscosity syndrome associated with autoantibodies. Three sessions of plasma exchange therapy were made, and clinical improvement was observed. He was then discharged from the intensive care unit and hospital, respectively. He is now attended by an external consult and has no respiratory symptomatology.

Conclusions
Hyperviscosity syndrome with pulmonary arterial hypertension presentation in a patient with acquired von Willebrand disease in an autoimmune context is a rare condition that can be treated successfully with plasmapheresis and critical care support.
How is epigenetic information maintained through DNA replication?
Authors: Budhavarapu Varija N , Chavez Myrriah , Tyler Jessica K 
Published: October 2013

Abstract
DNA replication is a highly conserved process that accurately copies the genetic information from one generation to the next. The processes of chromatin disassembly and reassembly during DNA replication also have to be precisely regulated to ensure that the genetic material is compactly packaged to fit into the nucleus while also maintaining the epigenetic information that is carried by the histone proteins bound to the DNA, through cell divisions. Half of the histones that are deposited during replication are from the parental chromatin and carry the parental epigenetic information, while the other half of the histones are newly-synthesized. It has been of growing interest to understand how the parental pattern of epigenetic marks is re-established on the newly-synthesized histones, in a DNA sequence-specific manner, in order to maintain the epigenetic information through cell divisions. In this review we will discuss how histone chaperone proteins precisely coordinate the chromatin assembly process during DNA replication. We also discuss the recent evidence that histone-modifying enzymes, rather than the parental histones, are themselves epigenetic factors that remain associated with the DNA through replication to re-establish the epigenetic information on the newly-assembled chromatin.
Transposable element evolution in Heliconius suggests genome diversity within Lepidoptera
Authors: Lavoie Christine A , Platt Roy N , Novick Peter A , Counterman Brian A , Ray David A 
Published: October 2013

Abstract

Background
Transposable elements (TEs) have the potential to impact genome structure, function and evolution in profound ways. In order to understand the contribution of transposable elements (TEs) to Heliconius melpomene, we queried the H. melpomene draft sequence to identify repetitive sequences.

Results
We determined that TEs comprise ~25% of the genome. The predominant class of TEs (~12% of the genome) was the non-long terminal repeat (non-LTR) retrotransposons, including a novel SINE family. However, this was only slightly higher than content derived from DNA transposons, which are diverse, with several families having mobilized in the recent past. Compared to the only other well-studied lepidopteran genome, Bombyx mori, H. melpomene exhibits a higher DNA transposon content and a distinct repertoire of retrotransposons. We also found that H. melpomene exhibits a high rate of TE turnover with few older elements accumulating in the genome.

Conclusions
Our analysis represents the first complete, de novo characterization of TE content in a butterfly genome and suggests that, while TEs are able to invade and multiply, TEs have an overall deleterious effect and/or that maintaining a small genome is advantageous. Our results also hint that analysis of additional lepidopteran genomes will reveal substantial TE diversity within the group.
The immunobiology of the mammalian epididymis: the black box is now open!
Authors: Guiton Rachel , Henry-Berger Joelle , Drevet Joël R 
Published: October 2013

AbstractSpermatozoa represent an immunologic challenge for the mammalian males. They are produced long after the establishment of the immune library of the individual and harbor specific spermatic antigens that are found nowhere else in other organs, tissues and cells. Consequently, spermatozoa are somehow “foreign” to the male adaptive immune system. In order not to elicit autoimmune responses that would be detrimental for male fertility, spermatozoa should be either physically separated from the adaptive immune response and/or, the immune system challenged by spermatic antigens must be efficiently silenced. Within the mammalian male genital tract it becomes more and more obvious that a range of strategies are at stake to ensure that the immune-stranger spermatozoa do not constitute an immunological issue. In this review the focus will be on the immune status of the epididymis tubule, in which spermatozoa that have left the testes will mature for approximately 2 weeks and may be stored for prolonged period of time. How the epididymal immune environment compares to that of the testis and what are the immune regulatory processes at work in the epididymal compartment will only be briefly described. Instead, this review will focus on recent data that highlight epididymal immune regulatory actors that partly explain/illustrate the rather complicated, fragile but nevertheless robust immune environment of the epididymis.
Social design feedback: evaluations with users in online ad-hoc groups
Authors: Følstad Asbjørn , Hornbæk Kasper , Ulleberg Pål 
Published: September 2013

AbstractSocial design feedback is a novel approach to usability evaluation where user participants are asked to comment on designs asynchronously in online ad-hoc groups. Two key features of this approach are that (1) it supports interaction between user participants and development team representatives and (2) user participants can see and respond to other participants’ comments. Two design cases, involving 250 user participants, were studied to explore the output of social design feedback and investigate the effect of the two key features of this approach. Of all the design feedback, 17% was rated highly useful, and 21% contained change suggestions. The presence of an active moderator, representing the development team and interacting with the user participants, increased the usefulness of the design feedback. The opportunity to see and respond to others’ design feedback had a minor effect on the kind of design feedback provided, but no effect on usefulness. Based on the findings, we offer advice on how to implement social design feedback and suggest future research.
An Evaluation Of The Supplier Selection And Evaluation Process In Zimbabwean Universities
Authors: Mushanyuri Bongani 
Published: October 2013

Supplier selection and evaluation is fast becoming animportant strategic consideration in purchasing and supply.Suppliers play an influential role to the overall success of the buying organisation. Nowadays, supplier selection is firmly positioned as an alternative source for competitive advantage for organisations with regards to offering low cost, high quality products and services or achieving reliability to customers. As organisations become more dependent on suppliers, the direct and indirect consequences of poor decision making on supplier selection will become more critical. With the increasingly important role of suppliers in supply chain management, the selection process strategy has changed; other than scanning a series of pricelists only, qualitative, quantitative and environmental criteria have now been incorporated into the process.
An Intricate Multiple-Factor Approach To Evaluate Performance Of Indian Mutual Fund
Authors: Bhatt Suyash 
Published: October 2013

This research paper examines performance of top twelve Indian mutual funds by Asset Under Management (AUM). We use seven portfolio performance measurement parameters like Alpha, Beta, Standard Deviation, R Squared, Sharpe Ratio, Treynor Ratio and Jensen’s Alpha. The study reveals which amongst these mutual fund is the best performer based on all these parameters and the benchmark taken for this is NIFTY Index. The mutual funds selected are HDFC Top 200 Fund, Franklin India Bluechip Fund, ICICI Prudential Focused Bluechip Equity Fund, DSPBR Top 100 Equity Fund, Birla Sun Life Equity Fund, DSPBR Top 100 Equity Fund, UTI Mastershare Fund, Reliance Equity Opportunity Fund, SBI Magnum Equity, Reliance Top 200 Fund, SBI Bluechip Fund, ICICI Prudential Top 200 Fund, Principal Large Cap Fund. This study is primarily done to evaluate performance of the select mutual funds over a period of five years.
Reserves In Traditional And Contemporary Accounting
Authors: Klimczak Katarzyna 
Published: October 2013

The main aim of the article is to analyse concepts of reserves in traditional accounting models and the characteristics of the area of reserves in contemporary global accounting standards. Concepts of reserves in different countries are deeply rooted in the socio-economic environment of accounting. The differences in the significance, role and the scale of creation of reserves are especially evident in the Anglo-Saxon and continental accountingReserves play a very important role in the accounting system of IFRSs– they provide a specific control mechanism which enables companies to verify economic benefits embodied in their net assets.The analysis of the IFRSs rules concerning the creation of valuation reserves and provisions may lead to the conclusion that they are- above all – subject to true and fair view concept. The only purpose of reserves is to present faithfully the estimated loss in value of net assets. There are many requirements which are intended to prevent the undue use of reserves.The area of reserves is becoming more and more complex. The sources of complexity of reserves go beyond their inherent features and stem from the general orientation of contemporary accounting towards a model of anticipated losses/gains in net assets.
PROBLEMS AND OUTLOOK OF RESEARCH ACTIVITIES IN KAZAKHSTAN
Authors: Turdalieva Botagoz , Izekenova Aigulsum , Aimbetova Gulshara , Abdraimova Elmira , Raushanova Aizhan , Ramazanova Manshuk , Igissenova Alfiya , Sagyndykova Zarina , Kenessary Dinara , Zhanturiev Bolat 
Published: October 2013

Performance evaluation of scientific work on regional and individual levels can be achieved by the using scientometric methods of a quantitative analysis of bibliographic information available in such databases as Science Citation Index (SCI). Unfortunately, Kazakhstan scientific journals have not been included yet in the Thomson Reuters Corp. register of periodicals, that substantially distorts the actual national scientometric indexes. The analysis of Database “National Citation Reports” (Kazakhstan), which correlated with a contribution of Kazakhstan into the world science development, has shown the low level of research activities of Kazakhstan scientists on international arena. So, the share of international publications of Kazakhstan in the global flow is equal to 0,021 % (1044 doc.) that corresponds to the 87th place in the general list of countries of 177 names. Subject to the ranking of countries into groups by the number of the published works, Kazakhstan is referring to the group of 46 countries having 1000-10000 publications over 5 years, of which 8,6% in medicine. In this article the use of statistics and appropriate software by the authors of original articles in such journals as recommended by the Kazakh National Centre for Scientific & Technical Expertise (NCSTE) and included in the Database еlibrary.kz was evaluated. Research was conducted according to Research Report, due to which a research design and statistical analysis methods were estimated. In the rating of the research design, the authors of articles mostly used as follows: description of a series of cases–63,2%, description of the individual cases -27,1%, and description of specific cases–9,1%. A scope of selection in Section “Research Methods” was only calculated in 21,8% of cases, and in 63,9% of cases there was no description how the selection was carried out. Methods of analytical statistics were used in the 46,0% of cases. And there were references to the program package in use only in 17,5% of works. Thus shown that non-compliance with international standards in the preparation of scientific papers, primarily statistical requirements directly affect the quality and ratings of domestic articles.
Specifics Of Educational Programs’ Design In Andragogic Practice
Authors: Evarovich Svetlana 
Published: October 2013

Being an adult is an ontogenetic status whose qualitative characteristics define possibility of subject position display by a person in a role of a learner. Therefore, developing personal characteristics of adults through the channeled process of educational activities becomes a crucial necessity that stands before the educational sector of today.Nowadays, adults in Russia see the high value of educationas a factor of professional and personal success andnumerous efforts are extorted by the Russian system ofhigher education to utilize these potentials.This paper presents an analysis of theoretical approaches to adult educations organization in Russia and describes the key principles of andragogy as pedagogic conception.Our empirical analysis is based on expert face­to­faceinterviews. The purpose of the interviews was to revealrestrictions in andragogic principles implementation inelaborating educational programs for adults. The results ofour empirical exercise enable us to come up with the numberof unique characteristics of adult educational programsdesigning process in Russia as well as abroad.
Attitudes Towards The Governmental Authorities And Specific Features Of Self-Identification Of Business Support Programme Participants
Authors: Litvina Svetlana 
Published: October 2013

The article presents the results of empirical research on the Russian mentality. A regional sampling (inhabitants of Tomsk region of the Russian Federation) provided the basisfor investigating the attitude towards paternalism as concerning the governmental authorities and describing the psychological profiles of its two empirical types, such as"agreement paternalism" and "obedience paternalism". The interconnections of the paternalistic attitude, the Russian self­identity structure, and certain social­ demographic characteristics have been analysed. The article describes specific features of the paternalistic attitude and the self­identity structure of the participants of a business support programme in the Russian Federation.
Dynamics Of Growth In Human Population: The Effect Of Infectious Diseases
Authors: Strielkowskii Wadim , Lisinii Evgeny , Welkinsiii Emily 
Published: October 2013

In this paper, we present a new approach to modeling and analyzing the dynamics of growth in human population. Our analysis clearly shows that by now human population should have long reached and surpassed the 7 billion mark. The analysis also suggests that there possibly a whole array of factors hampering the growth of human population with infectious diseases being probably the most important one. The paper describes the most dangerous infectious diseases in human history and hypothesizes that they might be regarded as the “hidden factor” behind slowing down the exponential growth of human population. We conclude by proclaiming that infectious diseases might act as a natural mechanism of clearing out human population and therefore perform the role of the cleaning mechanism
Georges Teissier (1900–1972) and the Modern Synthesis in France
Authors: Loison Laurent 
Published: October 2013

AbstractThis Perspectives is devoted to the ideas of the French zoologist Georges Teissier about the mechanisms of evolution and the relations between micro- and macroevolution. Working in an almost universally neo-Lamarckian context in France, Teissier was one of the very few Darwinians there at the time of the evolutionary synthesis. The general atmosphere of French zoology during the 1920s and the 1930s will first be recalled, to understand the specific conditions in which Teissier became a zoologist. After a brief overview of his joint work with Philippe L’Héritier on the experimental genetics of Drosophila, this article describes the ways Teissier, during the 1950s, conceptualized the mechanisms that could allow for macroevolutionary transitions.
Some rare and interesting green algae (Chlorophyta) from subalpine Tatra lakes (High Tatra Mountains, Poland)
Authors: Lenarczyk Joanna , Tsarenko Petro 
Published: October 2013

Abstract
Five green algal taxa rarely occurring in the world were found in subalpine lakes of the High Tatra Mountains in Poland. These are Actinastrum gracillimum G.M. Sm. var. elongatum (G.M. Sm.) Fott, Monoraphidium tatrae (Hindák) Hindák, Pediastrum braunii Wartm. in Wartm. et Schenk, Scotiella tuberculata Bourr. var. tuberculata and Thelesphaera olivacea (Beck-Mannag.) Fott. The taxa are described and illustrated with light micrographs and drawings. A review of their distribution in the world is presented.
Anabaena poulseniana J. Boye Petersen — a species new to Polish flora
Authors: Richter Dorota 
Published: October 2013

Abstract
Anabaena poulseniana J. Boye Petersen Bot. Iceland 2, 1923 (Cyanobacteria), a cyanobacteria species new to Polish flora, was noted during a study of phytoplankton in one of Wrocław’s clay pits. The species was noted in plankton samples among Cylindrospermopsis raciborskii (Wołoszyńska) Seenayya et Subba Raju (Cyanobacteria) and Mougeotia sp. (Chlorophyta) filaments. The green algae created a bloom characterized by vegetation mats floating on the water.
The paper presents detailed characteristics for Anabaena poulseniana, and for the habitat and the ecological condition in the examined water reservoir during its presence. The paper also presents a comparison of morphological characteristics of A. poulseniana from Poland to the species from other geographical locations. The research will provide data on the morphology and ecology of the species. The species found during the study were documented in the form of original photos and illustrations.
Mercury in immature and adults Herring Gulls (Larus argentatus) wintering on the Gulf of Gdańsk area
Authors: Szumiło Emilia , Szubska Marta , Meissner Włodzimierz , Bełdowska Magdalena , Falkowska Lucyna 
Published: October 2013

Abstract
This study presents total mercury concentrations (HgT) in selected tissues and organs (blood, muscles, liver, kidneys, feathers and claws) of the herring gull (Larus argentatus) in order to assess the environmental pollution in the coastal zone of the southern Baltic. Dead, frozen birds were collected in the vicinity of Wladysławowo between December 2009 and March 2010, an exceptionally severe winter — a total of 13 specimens; 6 adults (>4 years old) and 7 immature birds (≤4 years old). Mercury concentrations in all analyzed samples exceeded the detection limit. The lowest average concentration, at a level of 0.4 μg Hg g−1 (d.w.) was observed in the muscles of adult and immature gulls while the highest, at a level of 3.3 μg Hg g−1 (d.w), was determined in the contour of immature gulls. A significant linear correlation was found between mercury concentration in the blood and the concentration in the kidneys and liver, with the coefficients of determination at R2 = 0.87 and 0.86, respectively. This indicates that blood of birds, as a mercury carrier, may reflects the concentration of mercury in tissues and internal organs of birds and, in the case of kidneys and liver, may express long-term exposure to mercury in nourishment.