bluuebunny/crossref_metadata_2025_split huggingface dataset:
Iatrogenic subcutaneous emphysema and pneumomediastinum following a high‐speed air drill dental treatment procedure
Authors: Nishimura Takeshi , Sawai Tatsuo , Kadoi Kanenori , Yamada Taihei , Yoshie Norichika , Ueda Takahiro , Nakao Atsunori , Kotani Joji 
Published: March 2015

CaseA patient was transported to our hospital with swelling in his right face and neck after restorative dental treatment. Subcutaneous emphysema and pneumomediastinum were discovered using computed tomography scans.OutcomeThe patient had no severe symptoms. We prescribed prophylactic antibiotics and he recovered uneventfully.ConclusionsClinicians must keep this pathology in mind because prompt diagnosis and treatment contribute to early improvement. Otherwise, patients may face life‐threatening complications.
Phosphahelicenes in Asymmetric Organocatalysis: [3+2] Cyclizations of γ‐Substituted Allenes and Electron‐Poor Olefins
Authors: Gicquel Maxime , Zhang Yang , Aillard Paul , Retailleau Pascal , Voituriez Arnaud , Marinetti Angela 
Published: March 2015

AbstractThe first use of phosphahelicene in enantioselective organocatalysis is reported. New chiral phosphahelicenes have been prepared and enable highly enantioselective [3+2] cyclization reactions between arylidene‐ or alkylidenemalononitriles and γ‐substituted allenoates or cyanoallenes. These reactions afford cyclopentene derivatives in both high yields and diastereoselectivities, with enantiomeric excesses of up to 97 %.
Construction of an Upconversion Nanoprobe with Few‐Atom Silver Nanoclusters as the Energy Acceptor
Authors: Xiao Yan , Zeng Lingyu , Xia Tian , Wu Zhengjun , Liu Zhihong 
Published: March 2015

AbstractHerein we report that few‐atom silver nanoclusters (Ag NCs) can be effective energy acceptors for upconversion phosphors (UCPs). A luminescence resonance energy transfer (LRET) probe for biothiols was constructed by decorating UCPs with dithiol‐stabilized Ag NCs. Owing to the unique properties of ultrasmall NCs, properties which bridge the gap between those of small molecules and those of nanoparticles, the use of approximately 1.9 nm Ag NCs as energy acceptors endows the probe with high energy‐transfer efficiency, good biocompatibility, and flexibility. The UCP–Ag NC nanoprobe enables rapid and robust target assay in solutions. It was also uploaded into living cells and used to detect intracellular biothiol levels with high discrimination. Moreover, the probe shows transportability in vivo and can be used for tissue imaging. The facile growth of few‐atom metal NCs on diverse templates may enable the development of various nanoprobes combining UCPs and metal NCs.
Carbazole Dendrimers as Solution‐Processable Thermally Activated Delayed‐Fluorescence Materials
Authors: Albrecht Ken , Matsuoka Kenichi , Fujita Katsuhiko , Yamamoto Kimihisa 
Published: March 2015

AbstractRecently, thermally activated delayed fluorescence (TADF) materials have received increasing attention as effective emitters for organic light‐emitting diodes (OLEDs). However, most of them are usually employed as dopants in a host material. In this report, carbazole dendrimers with a triphenyl‐s‐triazine core are reported, which are the first solution‐processable, non‐doped, high‐molecular‐weight TADF materials. The dendrimers were obtained by a new and facile synthetic route using the tert‐butyldimethylsilyl moiety as a protecting group. All dendrimers showed TADF in toluene. Measurements of the temperature‐dependent luminescence lifetime revealed that spin‐coated neat films also showed TADF with moderate quantum yields. OLED devices incorporating these dendrimers as spin‐coated emitting layers gave external quantum efficiencies of up to a 3.4 %, which suggests that this device is harvesting triplet excitons. This result indicates that carbazole dendrimers with attached acceptors are potential TADF materials owing to their polarized electronic structure (with HOMO–LUMO separation).
In situ electrochemical synthesis of a poly(o‐anisidine) counter electrode for a dye‐sensitized solar cell
Authors: Menaka Chandrasekaran , Manisankar Paramasivam , Stalin Thambusamy 
Published: March 2015

ABSTRACTPoly(o‐anisidine) (POA) counter electrodes (CEs) were fabricated by potentiodynamic deposition and incorporated into platinum (Pt)‐free dye‐sensitized solar cells (DSSCs). A different sweep number had great impact on the morphology and electrocatalytic activity of the POA films. The POA film fabricated by 25 sweep cycles was observed to have a highly porous morphology, and this resulted in a lower charge‐transfer resistance of 57 cm2 in comparison with the Pt CE. The DSSC assembled with the POA CE showed a higher photovoltaic conversion efficiency of 1.67% compared to 1.2% for the DSSC with the Pt CE under full sunlight illumination. Therefore, the high active surface area of the 25‐sweep‐segmented POA film could be considered a promising alternative CE for use in DSSCs because of its high electrocatalytic performance and electrochemical stability. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 42041.
Bioprocessing analysis of Pyrococcus furiosus strains engineered for CO2‐based 3‐hydroxypropionate production
Authors: Hawkins Aaron B. , Lian Hong , Zeldes Benjamin M. , Loder Andrew J. , Lipscomb Gina L. , Schut Gerrit J. , Keller Matthew W. , Adams Michael W.W. , Kelly Robert M. 
Published: March 2015

ABSTRACTMetabolically engineered strains of the hyperthermophile Pyrococcus furiosus (Topt 95–100°C), designed to produce 3‐hydroxypropionate (3HP) from maltose and CO2 using enzymes from the Metallosphaera sedula (Topt 73°C) carbon fixation cycle, were examined with respect to the impact of heterologous gene expression on metabolic activity, fitness at optimal and sub‐optimal temperatures, gas‐liquid mass transfer in gas‐intensive bioreactors, and potential bottlenecks arising from product formation. Transcriptomic comparisons of wild‐type P. furiosus, a genetically‐tractable, naturally‐competent mutant (COM1), and COM1‐based strains engineered for 3HP production revealed numerous differences after being shifted from 95°C to 72°C, where product formation catalyzed by the heterologously‐produced M. sedula enzymes occurred. At 72°C, significantly higher levels of metabolic activity and a stress response were evident in 3HP‐forming strains compared to the non‐producing parent strain (COM1). Gas–liquid mass transfer limitations were apparent, given that 3HP titers and volumetric productivity in stirred bioreactors could be increased over 10‐fold by increased agitation and higher CO2 sparging rates, from 18 mg/L to 276 mg/L and from 0.7 mg/L/h to 11 mg/L/h, respectively. 3HP formation triggered transcription of genes for protein stabilization and turnover, RNA degradation, and reactive oxygen species detoxification. The results here support the prospects of using thermally diverse sources of pathways and enzymes in metabolically engineered strains designed for product formation at sub‐optimal growth temperatures. Biotechnol. Bioeng. 2015;112: 1533–1543. © 2015 Wiley Periodicals, Inc.
Mass spectrometry‐based metabolomics: applications to biomarker and metabolic pathway research
Authors: Zhang Aihua , Sun Hui , Yan Guangli , Wang Ping , Wang Xijun 
Published: March 2015

AbstractMass spectrometry‐based metabolomics has become increasingly popular in molecular medicine. High‐definition mass spectrometry (MS), coupled with pattern recognition methods, have been carried out to obtain comprehensive metabolite profiling and metabolic pathway of large biological datasets. This sets the scene for a new and powerful diagnostic approach. Analysis of the key metabolites in body fluids has become an important part of improving disease diagnosis. With technological advances in analytical techniques, the ability to measure low‐molecular‐weight metabolites in bio‐samples provides a powerful platform for identifying metabolites that are uniquely correlated with a specific human disease. MS‐based metabolomics can lead to enhanced understanding of disease mechanisms and to new diagnostic markers and has a strong potential to contribute to improving early diagnosis of diseases. This review will highlight the importance and benefit with certain characteristic examples of MS‐metabolomics for identifying metabolic pathways and metabolites that accurately screen for potential diagnostic biomarkers of diseases. Copyright © 2015 John Wiley & Sons, Ltd.
Integration of an EEG biomarker with a clinician's ADHD evaluation
Authors: Snyder Steven M. , Rugino Thomas A. , Hornig Mady , Stein Mark A. 
Published: March 2015

AbstractBackgroundThis study is the first to evaluate an assessment aid for attention‐deficit/hyperactivity disorder (ADHD) according to both Class‐I evidence standards of American Academy of Neurology and De Novo requirements of US Food and Drug Administration. The assessment aid involves a method to integrate an electroencephalographic (EEG) biomarker, theta/beta ratio (TBR), with a clinician's ADHD evaluation. The integration method is intended as a step to help improve certainty with criterion E (i.e., whether symptoms are better explained by another condition).MethodsTo evaluate the assessment aid, investigators conducted a prospective, triple‐blinded, 13‐site, clinical cohort study. Comprehensive clinical evaluation data were obtained from 275 children and adolescents presenting with attentional and behavioral concerns. A qualified clinician at each site performed differential diagnosis. EEG was collected by separate teams. The reference standard was consensus diagnosis by an independent, multidisciplinary team (psychiatrist, psychologist, and neurodevelopmental pediatrician), which is well‐suited to evaluate criterion E in a complex clinical population.ResultsOf 209 patients meeting ADHD criteria per a site clinician's judgment, 93 were separately found by the multidisciplinary team to be less likely to meet criterion E, implying possible overdiagnosis by clinicians in 34% of the total clinical sample (93/275). Of those 93, 91% were also identified by EEG, showing a relatively lower TBR (85/93). Further, the integration method was in 97% agreement with the multidisciplinary team in the resolution of a clinician's uncertain cases (35/36). TBR showed statistical power specific to supporting certainty of criterion E per the multidisciplinary team (Cohen's d, 1.53). Patients with relatively lower TBR were more likely to have other conditions that could affect criterion E certainty (10 significant results; P ≤ 0.05). Integration of this information with a clinician's ADHD evaluation could help improve diagnostic accuracy from 61% to 88%.ConclusionsThe EEG‐based assessment aid may help improve accuracy of ADHD diagnosis by supporting greater criterion E certainty.
π‐Extended Indenofluorenes
Authors: Rao M. Rajeswara , Desmecht Antonin , Perepichka Dmitrii F. 
Published: March 2015

AbstractA series of π‐extended aromatic indenofluorene (IF) analogues with naphthalene and anthracene cores have been synthesized through acid‐catalyzed intramolecular cyclization. The regioselectivity of the reaction is controlled by a combination of steric and electronic factors and in some cases several possible regioisomers have resulted from the same precursor. The effects of ring connectivity on the optoelectronic properties were investigated by DFT calculations, absorption/emission spectroscopy, cyclic voltammetry, and spectroelectrochemical studies. All regioisomers exhibited a redshift of their absorption/emission bands relative to the parent IF analogues, but the magnitude of this shift and other optoelectronic properties (luminescence quantum yield, etc.) depends on the ring connectivity in a less obvious manner.
Frontispiece: Unusual Bonding and Properties in Main Group Element Chemistry: Rational Synthesis, Characterization, and Experimental Electron Density Determination of Mixed‐Valent Tetraphosphetes
Authors: Breuers Verena , Lehmann Christian W. , Frank Walter 
Published: March 2015

Phosphorus HeterocyclesExceptional bonding and molecular properties are observed in mixed‐valent tetraphosphetes now accessible by a simplified synthetic protocol. Besides anisotropic absorption of visible light and remarkable 31P NMR chemical shifts, the dispirocyclic compounds combine bis(ylidic) properties with elements of non‐classical π‐bonding. For more details, see the Full Paper by V. Breuers, W. Frank and C. W. Lehmann on page 4596 ff.
ChemInform Abstract: High Pressure Stability of the Monosilicides of Cobalt and the Platinum Group Elements.
Authors: Hernandez J. A. , Vocadlo L. , Wood I. G. 
Published: March 2015

AbstractThe high pressure stability of CoSi, RuSi, RhSi, PdSi, OsSi, IrSi, and PtSi is investigated by static first‐principles calculations ≤ 300 GPa at 0 K using the VASP package for general gradient approximation with Perdrew‐Wang 91 pseudopotentials describing the core‐electron interactions.
ChemInform Abstract: Polar Space Group and Complex Magnetism in Ni11□(HPO3)8(OH)6: Towards a New Multiferroic Material?
Authors: Poienar M. , Maignan A. , Sfirloaga P. , Malo S. , Vlazan P. , Guesdon A. , Laine F. , Rouquette J. , Martin C. 
Published: March 2015

AbstractThe title compound is hydrothermally synthesized from aqueous mixtures of FePO4, Fe(NO3)3, and 2M aq.
ChemInform Abstract: Ionothermal Synthesis of Tetranuclear Borate Clusters Containing f‐ and p‐Block Metals.
Authors: Parker T. Gannon , Chown Amanda L. , Beehler Austin , Pubbi Divya , Cross Justin N. , Albrecht‐Schmitt Thomas E. 
Published: March 2015

AbstractReactions of oxides or halides of trivalent lanthanides and actinides or Bi with H3BO3 in the ionic liquid [bmim]Cl in the presence of a small amount of water (autoclave, 150 °C, 5 d; controlled cooling) result in the crystallization of a series of isomorphous tetranuclear borate clusters of general formula M4B22O36(OH)6 (H2O)13 (M: La, Ce, Pr, Nd, Sm, Eu, Gd, Pu, and Bi).
ChemInform Abstract: Unexpectedly Complex Crystalline Phases in the MSO3F—Ag(SO3F)2 Phase Diagram (M: Na, K, Rb, Cs).
Authors: Michalowski T. , Mazej Z. , Budzianowski A. , Jaglicic Z. , Leszczynski P. J. , Grochala W. 
Published: March 2015

AbstractCrystalline phases obtained by reactions of MSO3F (M: Na, K, Rb, Cs), AgSO3F, and (SO3F)2 (77 K → room temp., 2—5 d) are characterized by powder XRD, Raman spectroscopy, and magnetic measurements.
ChemInform Abstract: N‐Methylacridinium Salts: Carbon Lewis Acids in Frustrated Lewis Pairs for σ‐Bond Activation and Catalytic Reductions.
Authors: Clark Ewan R. , Ingleson Michael J. 
Published: March 2015

AbstractAn N‐methylacridinium salt is successfully used as catalyst for the reduction of aldimines and the hydrosilylation of alcohols.
ChemInform Abstract: Palladium‐Catalyzed Direct Cross‐Coupling of Organolithium Reagents with Aryl and Vinyl Triflates
Authors: Vila Carlos , Hornillos Valentin , Giannerini Massimo , Fananas‐Mastral Martin , Feringa Ben L. 
Published: March 2015

AbstractThe Pd‐catalyzed cross‐coupling of aryl triflate and a vinyl triflate with alkyllithium reagents (II) and aryllithiums (IV) is developed.
ChemInform Abstract: A Magnetically Separable Catalyst for Synthesis of 1‐Phenoxy‐2‐propanol via Atom‐Economic Reaction.
Authors: Feng Shide , Cao Fengyun , Lu Bin , Cai Qinghai 
Published: March 2015

AbstractReaction of phenol with propylene oxide using a Fe3O4‐supported Al2O3‐MgO catalyst gives the title compound in good yield (80.3% conversion, 88.1% selectivity) via regioselective ring‐opening.
ChemInform Abstract: Copper(II)‐Mediated O‐Arylation of Protected Serines and Threonines.
Authors: El Khatib Mirna , Molander Gary A. 
Published: March 2015

AbstractThe first report for the Chan—Lam cross‐coupling of serine and threonine derivatives, allowing access to novel unnatural β‐aryloxy‐α‐amino acid derivatives, is described.
ChemInform Abstract: Ruthenium‐Catalyzed Alkoxycarbonylation of Alkenes with Paraformaldehyde as a Carbon Monoxide Substitute.
Authors: Liu Qiang , Wu Lipeng , Jackstell Ralf , Beller Matthias 
Published: March 2015

AbstractTitle reaction affords a variety of industrially important esters using easy‐to‐handle paraformaldehyde as carbonyl source.
ChemInform Abstract: N‐Heterocyclic Carbene‐Stabilized Palladium Complexes as Organometallic Catalysts for Bioorthogonal Cross‐Coupling Reactions.
Authors: Ma Xueji , Wang Hangxiang , Chen Wanzhi 
Published: March 2015

AbstractThis synthetic method is also used for the bioorthogonal labelling of proteins on cellular surfaces.
ChemInform Abstract: Highly Enantioselective Construction of Polycyclic Spirooxindoles by Organocatalytic 1,3‐Dipolar Cycloaddition of 2‐Cyclohexenone Catalyzed by Proline‐Sulfonamide.
Authors: Xiao Jun‐An , Liu Qi , Ren Ji‐Wei , Liu Jian , Carter Rich G. , Chen Xiao‐Qing , Yang Hua 
Published: March 2015

AbstractThe 1,3‐dipolar cycloaddition of in situ generated azomethine ylides and 2‐cyclohexenone is studied in the presence of a chiral proline‐sulfonamide catalyst.
ChemInform Abstract: Copper(I) Iodide Mediated Iodocyclization of Cyclopropylideneallenyl Ketones: Facile and Effective Synthesis of Highly Substituted Furan Derivatives.
Authors: Miao Maozhong , Xu Xin , Xu Lijun , Ren Hongjun 
Published: March 2015

AbstractA scalable, efficient, mild, and straightforward method for the synthesis of the title compounds is developed.
ChemInform Abstract: Copper‐Mediated Intramolecular Oxidative C—H/N—H Cross‐Coupling of α‐Alkenoyl Ketene N,S‐Acetals to Synthesize Pyrrolone Derivatives.
Authors: Huang Fei , Wu Ping , Wang Liandi , Chen Jiping , Sun Chenglin , Yu Zhengkun 
Published: March 2015

AbstractHighly functionalized pyrrolone derivatives, e.g. (VII) and (IX) are accessible via tuneable C—S and C—Cl bond cleavage.
ChemInform Abstract: Asymmetric Alkynylation/Lactamization Cascade: An Expeditious Entry to Enantiomerically Enriched Isoindolinones.
Authors: Bisai Vishnumaya , Suneja Arun , Singh Vinod K. 
Published: March 2015

AbstractA facile protocol is presented for the highly enantioselective alkynylation/lactonization reaction sequence of 2‐formylbenzoates with anilines and alkynes to form various isoindolinone derivatives.
ChemInform Abstract: A K2CO3‐Mediated Regioselective Synthesis of Indole/Pyrrole‐Fused 1,4‐Oxazines: An Unexpected Indole‐Fused Azlactone Synthesis.
Authors: Vandavasi Jaya Kishore , Hu Wan‐Ping , Senadi Gopal Chandru , Boominathan Siva Senthil Kumar , Chen Hsing‐Yin , Wang Jeh‐Jeng 
Published: March 2015

AbstractBoth terminal and internal alkynes are tolerated, but reactions with the latter are more sluggish due to increased steric hindrance.
ChemInform Abstract: p‐Toluenesulfonic Acid‐Promoted, I2‐Catalyzed Sulfenylation of Pyrazolones with Aryl Sulfonyl Hydrazides.
Authors: Zhao Xia , Zhang Lipeng , Li Tianjiao , Liu Guiyan , Wang Haomeng , Lu Kui 
Published: March 2015

AbstractThe I2‐catalyzed cross‐coupling of pyrazolones with aryl sulfonyl hydrazides furnishes aryl pyrazolone thioethers.
ChemInform Abstract: Reaction for the Synthesis of Benzimidazol‐2‐ones, Imidazo[5,4‐b]‐, and Imidazo[4,5‐c]pyridin‐2‐ones via the Rearrangement of Quinoxalin‐2‐ones and Their Aza Analogues when Exposed to Enamines.
Authors: Mamedov Vakhid A. , Zhukova Nataliya A. , Zamaletdinova Anastasiya I. , Beschastnova Tat'yana N. , Kadyrova Milyausha S. , Rizvanov Il'dar Kh. , Syakaev Victor V. , Latypov Shamil K. 
Published: March 2015

AbstractThe rearrangement process includes a novel ring contraction as the key step to produce various benzimidazole structures bearing a pyrrole part at one of the nitrogens.
ChemInform Abstract: Silyl Enol Ether Prins Cyclization: Diastereoselective Formation of Substituted Tetrahydropyran‐4‐ones.
Authors: Tay Gidget C. , Huang Chloe Y. , Rychnovsky Scott D. 
Published: March 2015

AbstractThe corresponding starting compounds are prepared in a 4 step sequence via weinreb amide intermediates.
ChemInform Abstract: Metal‐Free One‐Pot Synthesis of Amides Using Graphene Oxide as an Efficient Catalyst.
Authors: Kumari Shweta , Shekhar Amiya , Mungse Harshal P. , Khatri Om P. , Pathak Devendra D. 
Published: March 2015

AbstractThe method for the title synthesis needs no transition metal catalysts and proceeds in shorter reaction time.
ChemInform Abstract: Dehydrogenative Cross‐Coupling Reaction by Cooperative Transition‐Metal and Broensted Acid Catalysis for the Synthesis of β‐Quinolinyl α‐Amino Acid Esters.
Authors: Zhu Zhi‐Qiang , Bai Peng , Huang Zhi‐Zhen 
Published: March 2015

AbstractA novel dehydrogenative cross‐coupling reaction of methylquinoline derivatives with N‐aryl glycine esters under the cooperative catalysis of copper salt and a Broensted acid is developed.
ChemInform Abstract: Rhodium(III)‐Catalyzed C—C and C—O Coupling of Quinoline N‐Oxides with Alkynes: Combination of C—H Activation with O‐Atom Transfer.
Authors: Zhang Xueyun , Qi Zisong , Li Xingwei 
Published: March 2015

AbstractIn the efficient redox‐neutral coupling of quinoline N‐oxides with alkynes the N‐O bond acts as both directing group for C‐H activation and as an O‐atom donor.
ChemInform Abstract: Triflic Acid Promoted Fries Rearrangement of C‐3 Vinyl/isopropenyl‐azetidin‐2‐ones: Single‐Pot Synthesis of C‐3 Functionalized‐2‐aryl‐2,3‐dihydro‐quinoline‐4(1H)‐ones.
Authors: Mehra Vishu , Singh Parvesh , Bisetty Krishna , Kumar Vipan 
Published: March 2015

AbstractAt lower reaction temperatures the corresponding tautomer of (II) can be isolated alongside.
ChemInform Abstract: Thiourea as an Efficient Organocatalyst for the Transfer Hydrogenation of 2‐Substituted Quinoline Derivatives.
Authors: Qiao Xiang , Zhang Zhiguo , Bao Zongbi , Su Baogen , Xing Huabin , Yang Qiwei , Ren Qilong 
Published: March 2015

AbstractA variety of quinoline derivatives (I) is very simply and conveniently hydrogenated using Hantzsch ester as the hydrogen source.
ChemInform Abstract: One‐Pot α‐Amidosulfone‐Mediated Variation of the Pictet—Spengler Tetrahydroisoquinoline Synthesis, Suitable for Amide‐Type Substrates.
Authors: Arroyo Francisco J. , Lopez‐Alvarado Pilar , Ganesan A. , Menendez J. Carlos 
Published: March 2015

AbstractThe title reaction allows the preparation of tetrahydroisoquinolines (III) without the need for strong acid catalysis.
ChemInform Abstract: Concise Synthesis of Substituted Quinolizin‐4‐ones by Ring‐Closing Metathesis.
Authors: Alanine Thomas A. , Galloway Warren R. J. D. , McGuire Thomas M. , Spring David R. 
Published: March 2015

AbstractStarting from 6‐bromo‐2‐pyridone a novel strategy for the synthesis of 4H‐quinolizin‐4‐ones is developed.
ChemInform Abstract: Base‐Promoted Annulation of α‐Hydroxy Ketones and Dimethyl But‐2‐ynedioate: Straightforward Access to Pyrano[4,3‐a]quinolizine‐1,4,6(2H)‐triones and 2H‐Pyran‐2,5(6H)‐diones.
Authors: He Haitao , Qi Chaorong , Ou Yanglu , Xiong Wenfang , Hu Xiaohan , Ren Yanwei , Jiang Huanfeng 
Published: March 2015

AbstractWhile 3‐aryl‐2‐ketopropanols (X) exclusively give the pyrandiones (XI), 3‐pyridyl derivatives give either pyrandiones (VII) and (IX) or pyranoquinolizinetriones (III) and (V) depending on the substitution pattern at the pyridine moiety.
ChemInform Abstract: Synthesis of Bicyclic N,N‐Enaminals by Cyclization of Alk‐4‐ynals with Aliphatic Diamines in DMSO upon Treatment with KOH.
Authors: Gvozdev V. D. , Shavrin K. N. , Nefedov O. M. 
Published: March 2015

AbstractIt is shown that reactions of alkynals with 1,3‐diaminopropane and N‐methyl‐1,3‐diaminopropane lead to (E)‐6‐(arylmethylidene)octahydropyrrolo[1,2‐a]pyrimidines [ct.
ChemInform Abstract: Synthesis and Cytotoxic Activity of 1‐{3‐[1‐(5‐Organylsilylfuran‐2‐yl)silinan‐1‐yl]propyl}amines and Some Trimethylgermyl Analogues.
Authors: Ignatovich Luba , Romanovs Vitalijs , Muravenko Velta , Sleiksha Ilze , Popelis Jury , Shestakova Irina 
Published: March 2015

AbstractSubstrates (III) are prepared following the method demonstrated for (IIIa).