bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Virtual Reality in 360 degrees Video to Improve Standard Precautions Compliance amongst Nursing Students
Authors: Triyanto Endang , Kusumawardani Lita Heni , Jauhar Muhamad , Rasdiyanah Rasdiyanah , Rohana I Gusti Ayu Putu Desy , Rachmawati Utami 
Published: August 2024

Nursing students need effective learning methods to improve their abilities and skills in achieving competency. Virtual care reality in 360o videos is an alternative solution to a real and concrete learning method. This study aims to determine the effect of virtual care reality in 360o (VCR 360o) videos on compliance with standard precautions in nursing professional students. The study used a randomized control trial with the sample of 32 students for each group was obtained through a random sampling technique. This research was conducted at two state universities in Indonesia in 2022 and provided an intervention in the form of a 360o VCR for 17 minutes at least three times in each video containing material on standard precautions. A standard precautions compliance questionnaire was employed to investigate the main variable with a further analysis using paired t-test and independent t-test. The results of the study showed that there was a significant effect of the VCR 360o on increasing standard precautions compliance among students (p = 0.004). The research results are expected to be applied in the learning process of nurses in tertiary institutions and other learning topics.
PENENTUAN UKURAN SAMPEL MENGGUNAKAN RUMUS BERNOULLI DAN SLOVIN: KONSEP DAN APLIKASINYA
Authors: Majdina Nadhilah Idzni , Pratikno Budi , Tripena Agustini 
Published: August 2024

ABSTRACT. The research discussed a sample survey to draw the population inference based on the sample from that population. There are several techniques to take a sample size, but here we focused to use the Bernoulli’s and Slovin’s formula. This study aims to: (1) reconstruct the Bernoulli’s and Slovin’s formula and (2) examine the conditions (properties) in using the Bernoulli’s and Slovin’s formula. Here, we used a simple random sampling (SRM). Furthermore, both the reconstruction of Bernoulli's and Slovin's formula used the SRM as a sampling technique. This is due to the simple random sampling is a sampling technique that does not try to reduce the effect of variation or variance of data (on estimation errors). The results showed that the Bernoulli’s formula is used to determine sample size which estimates the infinite population proportion. Here, the assumption of the level of confidence is any values and the variance of the population is given as with p is any real value of the proportion between 0 and 1. Meanwhile, the Slovin’s formula is used to determine the sample size which estimates the finite population proportion with the confidence levels from 87%<=1-\alpha<=99%, where p is better to be 0.5. This is due to it will produce the maximum samples.Keywords: Bernoulli’s Formula, Solvin’s Formula, sample size, and survey sample.
ABSTRAK. Riset ini membahas survei sampel dalam upayanya menarik kesimpulan populasi berdasarkan informasi yang diperoleh dari sampel dalam populasi. Beberapa teknik sampling untuk menentukan ukuran sampel relatif banyak sehingga riset ini difokuskan untuk menggunakan ukuran sampel berdasarkan metode (rumus) Bernoulli dan Slovin. Selanjutnya, riset ini dilakukan untuk: (1) merekonstruksi rumus Bernoulli dan rumus Slovin dan (2) mengkaji ketentuan penggunaan (properties) dari kedua metode (rumus) tersebut, Bernoulli dan Slovin. Pada riset ini, metode pengambilan sampel yang digunakan adalah simple random sampling (SRM), yang mana model ini digunakan sebagai teknik sampling yang mendasari rekonstruksi rumus Bernoulli dan rumus Slovin. Hal ini, karena SRM merupakan salah satu teknik sampling yang tidak mengurangi pengaruh variansi atau keragaman data pada kesalahan estimasi. Hasil penelitian referensi menunjukan bahwa metode Benoulli dipakai estimasi ukuran sampel infinite population proportion. Pada konsep ini, asumsi keragaman populasi yang dimasukkan dalam perhitungan adalah pq/n dengan nilai p diambil sembarang, dan error ditentukan peneliti. Sedangkan metode Slovin dipakai untuk menentukan estimasi ukuran sampel finite population proportion, dengan tingkat kepercayaan adalah 87%<=1-\alpha<=99%, dimana nilai tidak boleh mendekati 0 atau 1, tetapia mendekati 0,5 merupakan pilihan terbaik yang menghasilkan sampel terbanyak.Kata Kunci: Metode Bernoulli, rumus Slovin, survey sampel, dan ukuran sampel
Complex de novo structural variants are an underestimated cause of rare disorders
Authors: Rahbari Raheleh , Jung Hyunchul , Yang Tsun-Po , Walker Susan , Danecek Petr , Garcia-Salinas Omar , Neville Matthew D C , Cortés-Ciriano Isidro , Firth Helen , Scally Aylwyn , Hurles Matthew , Campbell Peter 
Published: August 2024

Abstract

Complex de novo structural variants (dnSVs) are crucial genetic factors in rare disorders, yet their prevalence and characteristics in rare disorders remain poorly understood. Here, we conducted a comprehensive analysis of whole-genome sequencing data of 12,568 families, including 13,698 offspring with rare diseases, as part of the UK 100,000 Genomes Project. We identified 1,872 dnSVs, constituting the largest dnSV dataset reported to date. Complex dnSVs (n=158; 8.4%) emerged as the third most common type of SV, following simple deletions and duplications. We classified 65% of these complex dnSVs into 11 subtypes, based on the classification established through the analysis of cancer whole genomes. 1.4% of probands with neurodevelopmental disorders harbour at least one complex dnSV, a rate two times higher than previously reported. Intriguingly, 12% of exon-disrupting pathogenic dnSVs and 22% of de novo deletions or duplications previously identified by array-based or exome-seq methods were found to be complex dnSVs. This study highlights the importance of complex dnSVs in rare disorders and demonstrates the necessity of careful genomic analysis to avoid overlooking these variants.
Bioinspired mechanical energy storage and non-dissipative release in hierarchically swollen and entangled hydrogels
Authors: Ikkala Olli , Savolainen Henri , Hosseiniyan Negar , Piedrahita-Bello Mario 
Published: August 2024

Abstract

Living tissues possess synergistic mechanical properties that facilitate specific functions. Unlike toughening allowed by promoted mechanical energy dissipation, by contrast, dissipation is minimized for mechanical energy storage and efficient release, such as facilitating animal jumping. Nature shows such resilient materials, e.g., resilin, and elastin, characteristically involving small strain with high stiffness. Such properties have rarely been achieved in synthetic hydrogels, even if hydrogels are considered analogous to living soft tissue. We show bioinspired resilient hydrogels with high energy storage at small strains and high stiffness upon repeated hydrogel swellings in mixtures of monomers, crosslinkers and water with subsequent photopolymerizations up to 7 hierarchical levels N. Towards higher N, the chains are progressively more coiled and entangled around the stretched chains of lower N, leading to hierarchical swelling. By controlling N, the approach allows to surpass even biological proteins for efficient energy storage. We show generality and application potential for soft robot jumpers.
Optimizing Vegetation Plantation for Carbon Sequestration and Water Consumption: A Case Study on the Beijing-Shanghai Expressway
Authors: PI Chengling , SHU Anping , RUBINATO Matteo , ZHANG Ziru , ZHANG Xin , Xiao Yulong , CHRISTIAN Huarez 
Published: August 2024

Abstract

Efficient vegetation planting is essential in highway construction to reduce greenhouse gas emissions and prevent ecological degradation. However, carbon sequestration has rarely been considered in previous optimization models for planting strategies in these environments. To address this gap, this study focuses on selecting five predominant shrub species—Ailanthus altissima, Robinia pseudoacacia, Vitex negundo var. heterophylla, Amorpha fruticosa, and Lespedeza bicolor—typical of the Linyi section of the Beijing-Shanghai Expressway. The study quantifies the carbon sequestration rates and water consumption of these species to demonstrate their contribution to climate change mitigation. Field data were collected in spring, summer, and autumn using the LI-6800 portable photosynthetic system. The NSGA-II was subsequently adopted to establish an optimal model, considering constraints of a planting area of 1000 m² and a water consumption limit of 1067.9 mm. Based on the recorded datasets and the implementation of NSGA-II, the optimized vegetation planting structure for this area comprised Ailanthus altissima (21%), Robinia pseudoacacia (30%), Vitex negundo var. heterophylla (11%), Amorpha fruticosa (26%), and Lespedeza bicolor (12%). By adopting this novel solution, the carbon sequestration capacity per square kilometer increased by 541 kg, while water consumption decreased by 104 mm. This manuscript exemplifies achieving a balance between ecological and economic benefits through an optimized and targeted vegetation planting structure on highway slopes. Local and national authorities can use these results to implement similar strategies in different areas.
Maximum Excess Heat Production by Pair Annihilation of Ionic Vacancies
Authors: Sugiyama Atsushi , Miura Makoto , Oshikiri Yoshinobu , Morimoto Ryoichi , Miura Miki , Osaka Tetsuya , Mogi Iwao , Yamauchi Yusuke , Aogaki Ryoichi 
Published: August 2024

Abstract

Ionic vacancies created in an electrode reaction freely transfer like gas molecules in free space without collisions of water molecules in the electrolyte solution. Based on the kinetic model of gases, the collision process between the ionic vacancies with opposite charges was theoretically examined, and to calculate the maximum excess heat emitted by their pair annihilation, the diagram of the maximum collision efficiency against vacancy collision-cross-section was established from the previous data. Then, using double and triple bipolar Pt-magnetohydrodynamic (MHD) electrodes as well as a single one, we measured the maximum excess heat of the pair annihilation of monovalent vacancies in a ferricyanide-ferrocyanide redox reaction (FFRR) under a magnetic field of 15 T. The measured excess heats were in good agreement with the excess heats determined from the diagram.
Survival in Export Markets: Experience, Informal Network and Productivity
Authors: Tomasi Chiara , Roner Cristian 
Published: August 2024

Abstract

The paper explores the influence of learning processes and firms characteristics on the survival of export relationships for the universe of exporters belonging to an Italian region, Trentino. Exploiting the information for a long time period, between 2001 and 2019, the analysis unravels the distinct role played by previous experience and experimentation built up by an exporter for the success and survival of export relationships. Learning effects, especially at product rather than at destination level, are relevant to decrease the hazard rate. Being part of an informal network with other firms exporting the same product to the same destination contributes to increase the duration of export transactions. We further find evidence of the crucial role played by firms’ productivity in increasing the survival probability of export flows.
JEL codes: F14, C14, C41, D22, L25
Andrographolide enhances the antitumor activity of cisplatin by inhibiting the PI3K/AKT signaling pathway in bladder cancer
Authors: Xuan Lei , Bi Ran , Song Junnian , Zhu Yingjie 
Published: August 2024

Abstract

Bladder cancer (BC) is the most common malignant tumor of urinary system worldwide. Resistance to cisplatin(CDDP) in advanced bladder cancer leads to reduced survival rates. Andrographolide(Andro), an active ingredient extracted from Andrographis paniculate, has been reported to have multidimensional pharmacological properties. Here we report the therapeutic effect of Andro and CDDP on BC. BIU87 Cisplatin resistant (BIU87-CISR) cells were exposed to Andro or CDDP in different concentrations in vitro. In vivo, the subcutaneous tumor bearing (BIU87-CisR cells) mouse model was constructed. The results indicated combination therapy of Andro and CDDP significantly inhibited BIU87-CisR cells proliferation, migration and invasion. Andro treatment alleviated epithelial-to-mesenchymal transition (EMT) in BIU87-CisR cells. Furthermore, the combination treatment enhanced inhibition of Andro on PI3K/AKT signaling pathway. The molecular docking was also used to support the above results. Taken together, Andro enhanced the effect of CDDP therapy by modulating PI3K/AKT signaling pathway to reduce EMT in cisplatin resistant bladder cancer cells. This study provides a theoretical basis for the clinical application of Andro as an adjuvant drug in the treatment of BC.
Redox-Active Inverse Crowns for Small Molecule Activation
Authors: Harder Sjoerd , Maurer Johannes , Klerner Lukas , Mai Jonathan , Stecher Hannah , Thum Stefan , Morasch Michael , Langer Jens 
Published: August 2024

Abstract

The discovery of crown ether host-guest systems initiated the multidisciplinary field of supramolecular chemistry. Whereas cyclic crown ethers selectively bind metal cations in their center, the lesser known inverse crowns are rings of metal cations that efficiently bind anionic entities. In this role, inverse crowns enabled spectacular multiple deprotonation reactions, often with unusual selectivity. Self-assembly of the inverse crown around the multiply charged carbanion during the deprotonation reaction is the driving force for this reactivity. Here, we report on the synthesis of a pre-assembled inverse crown consisting of Na+ cations and a redox-active Mg0 center. We demonstrate its bifunctionality by reducing N2O and subsequent encapsulation of O2ˉ. Calculations reveal that this essentially barrier-free process involves a rare N2O2ˉ dianion, embedded in the inverse crown. The inverse crown can adapt itself for binding larger anions like N2O22ˉ, by extending the ring of metals cations. These redox-active inverse crowns combine the advantages of a strong reducing agent with anion stabilizing properties provided by the ring of metal cations, leading to high reactivity and selectivity.
Prognostic role of S100A9 expression and CD8+ T cells infiltration and their interaction in RCC
Authors: Ma Bo , Zhang Yifei , Zhu Wenliang , Tao Yiran , Yao Bing , Li Qian , Wang Dejuan , Qiu Jianguang 
Published: August 2024

Abstract

Background: Renal carcinoma is common and highly malignant, it is not sensitive to chemo-radiotherapy, leading its poor progression. Currently, S100A9 was found to be associated with several human malignancies. The purpose of this study is to investigate S100A9 expression in renal cancer and explore its role in cancer progression and its interaction with CD8+T cells.
Methods: We analyzed the subcluster and differentiation states of monocytes and CD8+T cells in RCC and their cellchart based on integrated scRNA-seq data. S100A9 expression and percentage of CD8+T cell infiltration in RCC tissue samples from 79 patients were assessed by immunohistochemistry.
Results: Monocytes were categorized into 5 clusters and S100A9 was mainly expressed by inflammatory cells on monocytes C1-1 in human RCC tissues, is a terminal status of monocytes and low expressed with immune checkpoints reported on monocytic cells. CD8+ T cells were defined into 5 clusters. Next, we identified strong interactions among Mono-C1-1 and ACT/CTL/EXT clusters with NAMPT-(IGTA5+IGTB1) and slightly interaction with VEGF pathway. Statistical analysis showed that a high percentage of S100A9 cells infiltration (> = 10%) in cancer tissues was positively correlated with poor prognosis. Further investigation found that S100A9 distribution in RCC was negatively related to CD8+ T cells infiltration.
Conclusions: Our results showed S100A9 was mainly expressed in monocytes, while S100A9 in RCC is associated with poor prognosis and negatively related to CD8+ T cells infiltration by NAMPT-(IGTA5+IGTB1) and VEGF pathway.
Family Phenotypic Profile in Hereditary Hemorrhagic Telangiectasia: Genotype-Phenotype Correlation in the Pediatric Population
Authors: Giorgio Valentina , Foggia Chiara Di , Quatrale Giovanna , Margiotta Gaia , Stella Giuseppe , Proli Francesco , Leoni Chiara , Onesimo Roberta , Passali Giulio Cesare , Contegiacomo Andrea , Zampino Giuseppe , Gasbarrini Antonio , Gaetani Eleonora 
Published: August 2024

Abstract

Hereditary Hemorrhagic Telangiectasia (HHT) is a rare, hereditary, autosomal dominant vascular disease, characterized by arteriovenous malformations (AVM), mucocutaneous telangiectasias and epistaxis. The management of pediatric patients is currently based on limited literature. The aim of our study is to evaluate whether the severity of HHT in affected children could be compared to their parents ‘phenotype, sharing the same genetic variants. We collected data about 11 pediatric patients and their parents with a confirmed diagnosis of HHT, from the medical records of Fondazione Policlinico Universitario A. Gemelli IRCCS (Rome, Italy). Starting from the analysis of the genotype-phenotype correlations among pediatric patients and their affected parents, we found that in three families (33,3%) the HHT presentation was similar between affected adults and affected siblings. In six families (67,7%) HHT phenotype was different between parents and children, being frequently more severe in parents rather than in children. Our results revealed a series of evidence confirming that HHT has variable phenotypic expressiveness.
Dynamic Modeling and Kinematics Verification for Quadruped Robot
Authors: Omar Abdullah , Rabie Ahmed , Thabet Doha , Abdellatif Ibrahim , Elsayed Kariman , Elbadawy Marwa , Shalaby Raafat 
Published: August 2024

Abstract

Legged robots rely on dynamic locomotion to navigate through unstructured environments and perform tasks effectively. Through a continuous cycle of lifting each leg off the ground with every step, these robots effortlessly traverse uneven terrain. Quadruped robots, a subset of legged robots, stand out for their ability to maintain stable ground contact using multiple points, allowing them to adapt to diverse landscapes and environmental challenges. This capability expands the robot's reach, enabling locomotion in areas that would otherwise be inaccessible. This paper presents a comprehensive analysis of kinematics and dynamics for quadruped robots. The study focuses on deriving forward and inverse kinematics equations to describe the robot's motion, alongside discussions and comparisons of different dynamical models including the Rigid body model, Centroid model, Single rigid body model, and Linear Inverted pendulum model. Additionally, finite element analysis with ANSYS is made which allowed for a detailed examination of structural performance between two leg models: Nova and Spot Mini. This analysis revealed that Spot Mini showed higher stress tolerance and deformation resistance compared to Nova. Moreover, Forward Kinematics has been verified using Peter Corke's robotics toolbox and Gazebo physical simulator. The results illustrate the optimal base height of the robot based on the error calculated between both simulators' given data.
Contextualizing Parthenium abundance with hydro-edaphic conditions and native plant species in different land systems in Baringo, Kenya
Authors: Sainepo Bernice Mereina , Behn Kai , Becker Mathias 
Published: August 2024

Abstract

Invasive species are a threat to biodiversity, altering ecosystem balances by affecting native species. Parthenium hysterophorus is a highly invasive weed that was introduced recently to Kenya, where it is rapidly spreading, particularly in the lowland areas around Lake Baringo in the semi-arid Rift Valley. The recent conversion of rangelands to crop fields created new habitats for the establishment of Parthenium, while the development of infrastructures (roads and irrigation canals) constituted seed dispersal corridors. The emergence of these new spatial-temporal patterns of land systems may differentially affect the dynamics of Parthenium spread and its ecological and economic implications. To understand the determinants and dynamics of Parthenium spread and their effects on native plant communities, we assessed the floristic composition in rangelands, croplands, and key infrastructures, and the hydro-edaphic properties associated with Parthenium abundance. Subsequently, we related Parthenium infestation to changes in the floristic composition in different land systems and seasons, based on 525 observation plots.
We recorded 63 species from 19 families. Perennial monocotyledonous species dominated the rangelands, while annual dicotyledonous species were associated with highly disturbed croplands and roadsides. Invasive Parthenium was recorded in all types of land use and infrastructures, except for the wet sodic grasslands. Hydro-edaphic conditions strongly affected the abundances of Parthenium. Densities and relative cover of Parthenium were highest during the wet season, in irrigated croplands, and along irrigation canals (38 individuals/ m2), with compacted poorly drained Gleysols and Fluvisols soils and shallow water tables. At high levels of Parthenium invasion, we observed a 50% reduction in the cover of native vegetation, with a differential displacement of specific native species. While several annual weedy species co-occurred with Parthenium, high abundance of Parthenium and C4-grasses tended to be mutually exclusive. Thus, Parthenium not only affected the biomass and cover of the native vegetation but also reduced the quality of rangeland and fallows for ruminant grazing. With progressing land system shifts towards intensified irrigated agriculture, and with the projected wetter futures with climate change in East Africa, Parthenium will increasingly affect the native vegetation in Baringo and in similar environments of East Africa.
The Physiological Activities, Layout, Spectrum, and Electrochemical Properties of Fe(Ii), Zn(Ii), and Co(Ii) Compounds, Include Pyrazine.2-carboxylic Acid Ligand and 2,2'-bipyridine
Authors: Kadhiravan S. , Veeravelan K. , Heryanto Heryanto , Elavarasan A. 
Published: August 2024

Abstract

Elements analysis, UV-Vis, FT-IR, and cyclic voltammetry have been used to characterize a new Iron (II), Zinc (II), and Cobalt (II) complex [Fe(II), Zn(II), Co(II)] complexes that contain 2,2'-bipyridine and pyrazine-2-carboxylic acid ligand. The interaction of this Fe (II), Zn (II), and Co (II) complex with calf thymus DNA techniques employed in fluorescence spectroscopy was investigated by UV-visible absorption. UV-Vis absorption studies yielded intrinsic binding constants (Kb) for the complex with CT-DNA of 1.9 x 104 and 2.1 x 104M− 1. Pseudomonas aeruginosa, Staphylococcus aureus, and Bacilli cereus pathogens were assessed for their antibacterial effectiveness against a range of microorganisms using nanosystems to determine the ligand and complex antibacterial activity.