bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cloud regime evolution in the Indian monsoon intraseasonal oscillation: Connection to large‐scale dynamical conditions and the atmospheric water budget
Authors: Wang Tao , Wong Sun , Fetzer Eric J. 
Published: October 2015

AbstractWe examine the intraseasonal oscillation (ISO) of the Indian summer monsoon to establish the connections of cloud regimes to large‐scale dynamical states defined by dynamical convergence and moisture advection. Over the Indian subcontinent, the developing phase toward ISO peaks (rainfall maximum) is associated with positive anomalies of moisture advection leading in 4–6 days to positive anomalies of dynamical convergence, triggering abrupt transitions from shallow cumulus to deep convections in 1–2 days. The decaying phase toward ISO troughs (rainfall minima) is associated with negative anomalies of moisture advection and decreasing dynamical convergence, accompanying opposite transitions in cloud regimes. Due to northward propagation of anomalies, processes over the Indian Ocean are similar but lead those over the subcontinent by ~10 days. During the transitions cirrus clouds always accompany but lag deep convective clouds by ~10 days. Over the equatorial Indian Ocean cirrus clouds are modulated by equatorial waves.
Quality assessment and consumer acceptability of bread from wheat and fermented banana flour
Authors: Adebayo‐Oyetoro Abiodun Omowonuola , Ogundipe Oladeinde Olatunde , Adeeko Kehinde Nojeemdeen 
Published: October 2015

AbstractBread was produced from wheat flour and fermented unripe banana using the straight dough method. Matured unripe banana was peeled, sliced, steam blanched, dried and milled, and sieved to obtain flour. The flour was mixed with water and made into slurry and allowed to stand for 24 h after which it was divided into several portions and blended with wheat flour in different ratios. Proximate and mineral compositions as well as functional, pasting, and sensory characteristics of the samples were determined. The results of proximate analysis showed that crude fiber ranged between 1.95% and 3.19%, carbohydrate was between 49.70% and 52.98% and protein was 6.92% and 10.25%, respectively, while iron was between 27.07 mg/100 g and 29.30 mg/100 g. Swelling capacity of the experimental samples showed a significant difference from that of control. Peak viscosity ranged between 97.00RVU and 153.63RVU for experimental samples compared with 392.35RVU obtained for the control. Most of the sensory properties for the experimental samples were significantly different from the control. This study showed that bread with better quality and acceptability can be produced from wheat–unripe banana blends.
The Art of Living with NZT and ICT: Dialectics of an Artistic Case Study
Authors: Zwart Hub 
Published: October 2015

Abstract
I wholeheartedly sympathize conceptually with Coeckelbergh’s paper. The dialectical relationship between vulnerability and technology constitutes the core of Hegel’s Master and Slave (the primal scene of contemporary philosophy). Yet, the empirical dimension is underdeveloped and Coeckelbergh’s ideas could profit from exposure to case studies. Building on a movie/novel (Limitless) devoted to vulnerability coping and living with ICT, I challenge the claim that modern heroism entails overcoming vulnerability with the help of enhancement and computers.
Does an Old Art Suffice for New Problems?
Authors: Swierstra Tsjalling 
Published: October 2015

Abstract
In this review I argue that Puech draws on two important currents in modern thought: the criticism of the ontological and social priority of conflict, and the rehabilitation of praxis vis-à-vis theoria. Still, his plea for a non-confrontational art of living leaves important questions unanswered. What is the problem exactly? What does exactly count as (non)confrontational? What is non-confrontation exactly meant to solve? What is the antiposition here? And: how does this new (or rather: old) art of living relate to the political and ethical varieties of Technology Assessment?
Synthesis, Characterization, Surface and Biological Activity of Diquaternary Cationic Surfactants Containing Ester Linkage
Authors: Migahed M. A. , Negm N. A. , Shaban M. M. , Ali T. A. , Fadda A. A. 
Published: October 2015

AbstractTwo series of diquaternary cationic surfactants designated as E9Nm and E11Nm having two different alkyl chains in their chemical structure were synthesized. The chemical structures of these surfactants were confirmed using elemental analysis, FTIR and 1H‐NMR spectra. The surface activities of the different surfactants were determined using surface and interfacial tension at 25 °C. The surface parameters including: critical micelle concentration, effectiveness, efficiency, maximum surface excess and minimum surface area were determined. The surface activities of the cationic surfactants were correlated with their chemical structure. The surface activities of the surfactants increased with increasing the hydrophobic chain length. The adsorption and micellization tendencies of the surfactants in solution were determined using the free energies of adsorption and micellization. The synthesized surfactants were evaluated as biocides against bacteria and fungi. Biocidal activity data showed that a gradual increase in the hydrophobic chain length of the surfactant molecules gradually increases the efficiency of these surfactants as biocides.
RETRACTED ARTICLE: Influence of the Disk Diameter and Baffle Position on the Performance of Generated Colloidal Gas Aphrons
Authors: Banifatemi Sina S. , Mohammadifard Hossein , Amiri Mohammad C. 
Published: October 2015

AbstractAphrons are surfactant‐stabilized microbubbles with thick soapy shells. Colloidal gas aphrons (CGA) with an average diameter of 50 μm have some unique properties: a high interfacial area due to their small size, a thick soapy shell and, above all, high stability compared to conventional foams. Various factors that can influence the performance of CGA dispersion, such as the type and concentration of surfactant, mixing time and processing parameters, have already been extensively studied. However, although CGA applications in various fields continue to advance, the influence of the disk diameter and baffle position of the aphron generator on the performance of CGAs has not been well studied. In this experimental work, the influences of the spinning disk diameter and baffle position inside the aphron generator have been investigated. Analyzing the drainage curve of various experimental runs revealed that the disk diameter and baffle position might have a positive impact on the stability of CGA dispersion particularly when the generation time or surfactant concentration is low. The experimental findings have been supported by other techniques such as half‐life time and a new stability index, T0.1, the time elapsed when the drained liquid from CGA dispersion reaches ten percent of its final height.
Clinical observation and therapeutic evaluation of intravenous pump of recombinant human endostatin combined with TP regimen in treating patients with advanced ovarian cancer
Authors: Zhang Chi , Deng Wen‐Ying , Li Ning , Luo Su‐Xia 
Published: October 2015

AbstractObjectivesTo observe the curative effects and adverse reactions of recombinant human (rh)‐endostatin injection combined with a TP regimen for treating patients with advanced ovarian cancer.MethodsFifty‐four patients with pathologically confirmed ovarian cancer were randomly divided into a combined treatment (intravenous pump of rh‐endostatin + TP regimen) group and a control (single chemotherapy) group, twenty‐seven patients in each group. All patients were given a conventional CT examination. The level of vascular endothelial growth factor (VEGF), the size of tumor before treatment, after 2 cycles and after 4 cycles of treatment were determined for the comparison of curative effects and adverse reactions.ResultsThe effective rate was 37.0% (10/27) and disease control rate was 63.0% (17/27) in the combined treatment group after 2 cycles of treatment. The effective rate was 25.9% (7/27) and disease control rate was 63.0% (17/27) in the control group. The comparison between these two groups showed no significant differences (P > 0.05). The effective rate was 63.0% (17/27) and disease control rate was 92.6% (25/27) in the combined treatment group after 4 cycles of treatment. The effective rate was 29.6% (8/27) and disease control rate was 63.0% (17/27) in the control group. The effective rate and disease control rate between these two groups after 4 cycles of treatment showed significant differences (P < 0.05). The incidences of cardiovascular toxicity, myelosuppression, sore muscles and joints, alopecia and gastrointestinal reaction was not significantly different between two groups (P > 0.05).ConclusionThe pump delivery of rh‐endostatin can down‐regulate the expression of VEGF in ovarian cancer and has the better curative effect and slighter adverse reactions.
Activist hedge funds and firm disclosure
Authors: Chen Jing , Jung Michael J. 
Published: October 2015

AbstractThis study examines whether firms' disclosure decisions are affected by the presence of activist hedge funds. Using a large sample of firms that experienced increases in ownership by activist hedge funds, we find that firms are more likely to cease providing financial guidance or reduce the information in the guidance in the quarter subsequent to new investment by activist hedge funds. These results hold even for firms that experienced good quarters and consistently provided guidance in previous quarters. Since guidance has been shown to be beneficial to capital market participants in many ways, reduced guidance has meaningful market implications. Our findings highlight a negative and possible unintended consequence of activist hedge funds' investment in firms, which provides some counterbalance to the numerous positive consequences documented in the prior literature on hedge fund activism.
On the high trail: examining determinants of site use by the Endangered snow leopard Panthera uncia in Qilianshan, China
Authors: Alexander Justine S. , Shi Kun , Tallents Lucy A. , Riordan Philip 
Published: October 2015

AbstractThere is a need for simple and robust techniques for assessment and monitoring of populations of the Endangered snow leopard Panthera uncia to inform the development of action plans for snow leopard conservation. We explored the use of occupancy modelling to evaluate the influence of environmental and anthropogenic features on snow leopard site-use patterns. We conducted a camera trap survey across 480 km2 in Gansu Province, China, and used data from 60 camera traps to estimate probabilities of site use and detection using the single season occupancy model. We assessed the influence of three covariates on site use by snow leopards: elevation, the presence of blue sheep Pseudois nayaur and the presence of human disturbance (distance to roads). We recorded 76 captures of snow leopards over 2,906 trap-days, representing a mean capture success of 2.62 captures per 100 trap-days. Elevation had the strongest influence on site use, with the probability of site use increasing with altitude, whereas the influence of presence of prey and distance to roads was relatively weak. Our findings indicate the need for practical and robust techniques to appraise determinants of site use by snow leopards, especially in the context of the limited resources available for such work.
Transcription factor and miRNA co-regulatory network reveals shared and specific regulators in the development of B cell and T cell
Authors: Lin Ying , Zhang Qiong , Zhang Hong-Mei , Liu Wei , Liu Chun-Jie , Li Qiubai , Guo An-Yuan 
Published: October 2015

AbstractThe maturation process of lymphocyte was related to many blood diseases, such as lymphoma and lymphoid leukemia. Many TFs and miRNAs were separately studied in the development of B and T cells. In this study, we aim to discover the TF and miRNA co-regulation and identify key regulators in the B and T cells maturation. We obtained the candidate genes, miRNAs and TFs for each stage of their maturation, then constructed the TF-miRNA-gene feed-forward loops (FFLs) for each stage by our previous methods. Statistical test for FFLs indicated their enrichment and significance. TF-miRNA co-regulatory networks for each stage were constructed by combining their FFLs. Hub analysis revealed the key regulators in each stage, for example, MYC, STAT5A, PAX5 and miR-17 ~ 92 in the transition of pro-B cells into pre-B cells. We also identified a few common regulators and modules in two stages of B cell maturation (e.g. miR-146a/NFKB1/BCL11A) and two stages of T cell maturation (e.g. miR-20/CCND2/SORL1), as well as some shared regulators in the early stages of both B and T cell development. Our network will help to increase understanding of mature process of B and T cell, as well as the related blood diseases.
Tunnelling anisotropic magnetoresistance due to antiferromagnetic CoO tunnel barriers
Authors: Wang K. , Sanderink J. G. M. , Bolhuis T. , van der Wiel W. G. , de Jong M. P. 
Published: October 2015

AbstractA new approach in spintronics is based on spin-polarized charge transport phenomena governed by antiferromagnetic (AFM) materials. Recent studies have demonstrated the feasibility of this approach for AFM metals and semiconductors. We report tunneling anisotropic magnetoresistance (TAMR) due to the rotation of antiferromagnetic moments of an insulating CoO layer, incorporated into a tunnel junction consisting of sapphire(substrate)/fcc-Co/CoO/AlOx/Al. The ferromagnetic Co layer is exchange coupled to the AFM CoO layer and drives rotation of the AFM moments in an external magnetic field. The results may help pave the way towards the development of spintronic devices based on AFM insulators.
The Diurnal Profile of Central Hemodynamics in a General Uruguayan
Population
Authors: Boggia José , Luzardo Leonella , Lujambio Inés , Sottolano Mariana , Robaina Sebastián , Thijs Lutgarde , Olascoaga Alicia , Noboa Oscar , Struijker-Boudier Harry A. , Safar Michel E. , Staessen Jan A. 
Published: October 2015

Abstract

BACKGROUND
No previous population study assessed the diurnal profile of central arterial properties.

METHODS
In 167 participants (mean age, 56.1 years; 63.5% women), randomly recruited in Montevideo, Uruguay, we used the oscillometric Mobil-O-Graph 24-h PWA monitor to measure peripheral and central systolic (SBP), diastolic (DBP), and pulse (PP) pressures and central hemodynamics standardized to a heart rate of 75 bpm, including aortic pulse wave velocity, systolic augmentation (first/second peak × 100), and pressure amplification (peripheral PP/central PP).

RESULTS
Over 24 hours, day and night, peripheral minus central differences in SBP/DBP and in PP averaged 12.2/−1.1, 14.0/−0.7, and 9.7/0.2mm Hg and 12.6, 14.7, and 9.5mm Hg, respectively ( P &lt; 0.001 except for nighttime DBP ( P = 0.38)). The central-to-peripheral ratios of SBP, DBP, and PP were 0.89, 1.00, and 0.70 unadjusted, but after accounting for anthropometric characteristics decreased to 0.74, 0.97, and 0.63, respectively, with strong influence of height for SBP and DBP and of sex for PP. From day (10–20h) to nighttime (0–6h), peripheral (−10.4/−10.5 mm Hg) and central (−6.0/−11.3mm Hg) SBP/DBP, pulse wave velocity (−0.7 m/s) and pressure amplification (−0.05) decreased ( P &lt; 0.001), whereas central PP (+5.3mm Hg) and systolic augmentation (+2.3%) increased ( P &lt; 0.001).

CONCLUSIONS
The diurnal rhythm of central pressure runs in parallel with that of peripheral pressure, but the nocturnal fall in SBP is smaller centrally than peripherally. pulse wave velocity, systolic augmentation, and pressure amplification loop through the day with high pulse wave velocity and pressure amplification but low systolic augmentation in the evening and opposite trends in the morning.
GERV: a statistical method for generative evaluation of regulatory variants for transcription factor binding
Authors: Zeng Haoyang , Hashimoto Tatsunori , Kang Daniel D. , Gifford David K. 
Published: October 2015

Abstract
Motivation: The majority of disease-associated variants identified in genome-wide association studies reside in noncoding regions of the genome with regulatory roles. Thus being able to interpret the functional consequence of a variant is essential for identifying causal variants in the analysis of genome-wide association studies.
Results: We present GERV (generative evaluation of regulatory variants), a novel computational method for predicting regulatory variants that affect transcription factor binding. GERV learns a k-mer-based generative model of transcription factor binding from ChIP-seq and DNase-seq data, and scores variants by computing the change of predicted ChIP-seq reads between the reference and alternate allele. The k-mers learned by GERV capture more sequence determinants of transcription factor binding than a motif-based approach alone, including both a transcription factor’s canonical motif and associated co-factor motifs. We show that GERV outperforms existing methods in predicting single-nucleotide polymorphisms associated with allele-specific binding. GERV correctly predicts a validated causal variant among linked single-nucleotide polymorphisms and prioritizes the variants previously reported to modulate the binding of FOXA1 in breast cancer cell lines. Thus, GERV provides a powerful approach for functionally annotating and prioritizing causal variants for experimental follow-up analysis.
Availability and implementation: The implementation of GERV and related data are available at http://gerv.csail.mit.edu/.
Contact: gifford@mit.edu
Supplementary information: Supplementary data are available at Bioinformatics online.
A-DaGO-Fun: an adaptable Gene Ontology semantic similarity-based functional analysis tool
Authors: Mazandu Gaston K. , Chimusa Emile R. , Mbiyavanga Mamana , Mulder Nicola J. 
Published: October 2015

Abstract
Summary: Gene Ontology (GO) semantic similarity measures are being used for biological knowledge discovery based on GO annotations by integrating biological information contained in the GO structure into data analyses. To empower users to quickly compute, manipulate and explore these measures, we introduce A-DaGO-Fun (ADaptable Gene Ontology semantic similarity-based Functional analysis). It is a portable software package integrating all known GO information content-based semantic similarity measures and relevant biological applications associated with these measures. A-DaGO-Fun has the advantage not only of handling datasets from the current high-throughput genome-wide applications, but also allowing users to choose the most relevant semantic similarity approach for their biological applications and to adapt a given module to their needs.
Availability and implementation: A-DaGO-Fun is freely available to the research community at http://web.cbio.uct.ac.za/ITGOM/adagofun. It is implemented in Linux using Python under free software (GNU General Public Licence).
Contact: gmazandu@cbio.uct.ac.za or Nicola.Mulder@uct.ac.za
Supplementary information: Supplementary data are available at Bioinformatics online.
iEnhancer-2L: a two-layer predictor for identifying enhancers and their strength by pseudo k-tuple nucleotide composition
Authors: Liu Bin , Fang Longyun , Long Ren , Lan Xun , Chou Kuo-Chen 
Published: October 2015

Abstract
Motivation: Enhancers are of short regulatory DNA elements. They can be bound with proteins (activators) to activate transcription of a gene, and hence play a critical role in promoting gene transcription in eukaryotes. With the avalanche of DNA sequences generated in the post-genomic age, it is a challenging task to develop computational methods for timely identifying enhancers from extremely complicated DNA sequences. Although some efforts have been made in this regard, they were limited at only identifying whether a query DNA element being of an enhancer or not. According to the distinct levels of biological activities and regulatory effects on target genes, however, enhancers should be further classified into strong and weak ones in strength.
Results: In view of this, a two-layer predictor called ‘iEnhancer-2L’ was proposed by formulating DNA elements with the ‘pseudo k-tuple nucleotide composition’, into which the six DNA local parameters were incorporated. To the best of our knowledge, it is the first computational predictor ever established for identifying not only enhancers, but also their strength. Rigorous cross-validation tests have indicated that iEnhancer-2L holds very high potential to become a useful tool for genome analysis.
Availability and implementation: For the convenience of most experimental scientists, a web server for the two-layer predictor was established at http://bioinformatics.hitsz.edu.cn/iEnhancer-2L/, by which users can easily get their desired results without the need to go through the mathematical details.
Contact: bliu@gordonlifescience.org, bliu@insun.hit.edu.cn, xlan@stanford.edu, kcchou@gordonlifescience.org
Supplementary information: Supplementary data are available at Bioinformatics online.
Plant phenological responses to climate change on the Tibetan Plateau: research status and challenges
Authors: Shen Miaogen , Piao Shilong , Dorji Tsechoe , Liu Qiang , Cong Nan , Chen Xiaoqiu , An Shuai , Wang Shiping , Wang Tao , Zhang Gengxin 
Published: October 2015

Abstract
Phenology studies the cycle of events in nature that are initiated and driven by an annually recurring environment. Plant phenology is expected to be one of the most sensitive and easily observable natural indicators of climate change. On the Tibetan Plateau (TP), an accelerated warming since the mid-1980s has resulted in significant environmental changes. These new conditions are accompanied by phenological changes that are characterized by considerable spatiotemporal heterogeneity. Satellite remote sensing observed widespread advance in the start of the plant growing season across the plateau during the 1980s and 1990s but substantial delay over 2000–2011 in the southwest although it continued to advance in the northeast regions of the TP. Both observational studies and controlled experiments have revealed, to some extent, the positive role of higher preseason temperature and even more precipitation in advancing the leaf onset and first flowering date of the TP. However, a number of rarely visited research issues that are essential for understanding the role of phenology in ecosystem responses and feedback processes to climate change remain to be solved. Our review recommends that addressing the following questions should be a high priority. How did other phenological events change, such as flowering and fruiting phenology? What are the influences from environmental changes other than temperature and precipitation, including human activities such as grazing? What are the genetic and physiological bases of plants phenological responses? How does phenological change influence ecosystem structure and function at different scales and feedback to the climate system? Investigating these research questions requires, first of all, new data of the associated environmental variables, and consistent and reliable phenological observation using different methodologies (i.e. in situ observations and remote sensing).