bluuebunny/crossref_metadata_2025_split huggingface dataset:
Biblical Mythopoeia, Gendered War and Sexuality in D. H. Lawrence's ‘Samson and Delilah’
Authors: Montori Irene 
Published: August 2024

Abstract
Grouped together with modernism's most eminent authors, D. H. Lawrence has been appreciated for his idiosyncratic response to his time and literary modernism. A good deal of critical attention has been given to his contribution to modernist fiction and, in this context, the present article focuses on some crucial aspects of Lawrence's modernism not hitherto addressed in his short story ‘Samson and Delilah’ (1917), in England, My England (1922). By reading ‘Samson and Delilah’ through the lens of modernist mythopoeia, this article aims to highlight Lawrence's reformulation of the biblical story as a way to come to terms with gendered war in national and personal spheres.
Scoring, Casting, Instilling
Authors: McKeon Ed 
Published: August 2024

Abstract
Ari Benjamin Meyers's Kunsthalle for Music is simultaneously an institution, an exhibition, a concert, a music collection, a process, and an ensemble. In this essay, I take readers on a tour of the show's first presentation, followed by reflections on questions that it posed. In particular, the project troubles the issue of art's mediums, their relation to art as a singular concept and its institutional form(s), and art's mode of cultural transmission through time. The philosopher Peter Osborne, who has written on and presented at the Kunsthalle, provides my theoretical foil alongside Theodor Adorno and Rosalind Krauss. I add musings by Jean-Luc Nancy to consider how the project exhibits liveness and its musical significance. Mediums of art are neither essences nor concepts for deconstruction, I conclude; rather, they insist and persist as modalities of action.
Evaluation of phenolic content in selected red fruit juices
Authors: Nieć-Leśniak Joanna , Szczepańska Elżbieta , Białek-Dratwa Agnieszka , Kiciak Agata , Niewiadomska Ewa 
Published: August 2024

BackgroundRed fruits are characterised by a particularly high content of bioactive compounds, e.g. anthocyanins, tannins, pectins, vitamins and minerals. Dietary supply of proper amounts of antioxidants is essential to reduce oxidative stress, and thus is an important element in the prevention of lifestyle diseases.ObjectiveThe aim of the study was to evaluate and compare the content of polyphenols in selected red fruit juices (chokeberry, elderberry, pomegranate, cranberry), as well as to assess the impact of storage time on the content of these compounds in the analysed samples.Material and MethodsThe research material consisted of 17 juices (100%): 3 chokeberry juices, 4 elderberry juices, 5 pomegranate juices and 5 cranberry juices, which differed in terms of the manufacturer, type, price range, country of origin and production method. The total polyphenol content was measured by spectrophotometry using the Folin�Ciocalteu reagent. The procedure was based on a modified method described by Waterhouse. Active acidity (pH) was measured with the potentiometric method using a pH-meter and the sucrose content was measured using a refractometer.ResultsThe highest mean content of polyphenolic compounds was found in chokeberry and elderberry juices. Juice storage time did not reduce the mean content of polyphenolic compounds. The highest sucrose content was found in chokeberry juices and the lowest in cranberry juice.ConclusionsChokeberry and elderberry juices had the highest content of polyphenols among the tested products. Juices stored after opening in accordance with the manufacturer’s instructions (at 4°C) do not lose their nutritional properties.
EXPRESSÃO DE RECEPTORES TOLL-LIKE E MODULAÇÃO DA RESPOSTA INFLAMATÓRIA PELO EXERCÍCIO FÍSICO: UMA REVISÃO SISTEMÁTICA
Authors: Soares Fonseca Yago , Oliveira Alves Calila , Guimarães Souza Lohana , Faccin Borges Grasiely , Miranda Botelho Teixeira Ana Maria 
Published: August 2024

Objetivou-se realizar uma revisão sistemática acerca da modulação da resposta inflamatória pela diminuição da expressão de receptores toll like (TLR) pelo exercício físico. Realizou-se busca sistemática nas bases de dados PUBMED e Google Scholar. Os artigos foram selecionados por meio da plataforma Raayan. Atenderam aos critérios de elegibilidade 19 estudos experimentais. Os resultados apontaram o exercício físico como modulador da resposta inflamatória, conduzindo a um estado anti-inflamatório transitório, sendo os de resistência e de longa duração aqueles com efeito direto sobre a modulação negativa do TLR. Para os aeróbicos é necessário considerar a intensidade e o tempo de intervenção.
Does physical effort affect the cognitive performance of police officers?
Authors: Faro Heloiana K. Campos 
Published: August 2024

BACKGROUND: The duty of police officers involves cognitive processes, furthermore, the firearm is usually preceded by foot pursuit, so it's important to understand whether physical exertion affects police officers' cognitive performance. We aimed to evaluate if physical exertion impacts cognitive performance in police officers. METHODS: The sample consisted of 14 male police officers. Inhibitory control was assessed using a version of the Stroop test before and after physical exertion. The response time (RT) and accuracy were used for the analysis. The Stroop effect was also measured. Participants were instructed to run a ~300 m on the simulated circuit of foot chase. Statistical tests were used to compare RT and accuracy. RESULTS: There was no change from pre- to post-exertion in RT and accuracy for congruent (all ps>0.62), neutral (all ps>0.77), or incongruent trials (all ps>0.15) of the Stroop test as well as the Stroop interference when considering RT (p=0.594) or accuracy (p=0.826). CONCLUSIONS: There was no effect of physical effort on the cognitive performance of police officers.
PERAWATAN MESIN BELT CONVEYOR
Authors: Saputra Anjas , Helmizar  , Witanto Yovan 
Published: August 2024

Abstrak: Belt conveyor berfungsi untuk memindahkan barang dalam jumlah banyak secara terus menerus dari ujung konveyor (awal) ke ujung konveyor yang lain (akhir). Adapun Prinsip kerja dari belt conveyor terdiri dari komponen utama dari mesin berupa sabuk yang prinsip kerjanya mengangkut material yang akan dipindahkan dari kapal bongkar muat atau dari reclaimer hopper. Bentuk fisik dari belt adalah sabuk yang memanjang di sepanjang conveyor. Perawatan pada belt conveyor dilakukan secara berkala, seperti perawatan mingguan dan perawatan bulanan. pemeliharaan pada setiap komponen. Perawatan berkala ini dilakukan mulai dari tahap pemeriksaan kerusakan dan tahap penggantian komponen yang rusak. Menganalisa dan mengamati mesin belt conveyor dengan mengumpulkan data-data masalah yang dapat merusak mesin belt conveyor dan dapat menghambat proses produksi

Kata kunci: konveyor sabuk, pemeliharaan preventif
POLA PENYEBARAN DAN PENILAIAN SUMBER DAYA BATUBARA DAERAH GERAMAT DAN SEKITARNYA
Authors: Adhitia Iit , Solihin Solihin , Pamungkas Helmi Setia Ritma , Irawan Robin 
Published: August 2024

ABSTRAK Daerah penyelidikan berada di area Geramat dan sekitarnya, Kecamatan Merapi Selatan, Kabupaten Lahat, Provinsi Sumatera Selatan termasuk bagian dari Cekungan Sumatera Selatan yang diestimasikan mengandung batubara cukup besar dikarenakan cekungan ini disusun oleh litologi yang terendapkan pada lingkungan darat – transisi sebagai bagian Formasi Muara Enim, terdapat formasi lainnya yang berdekatan yaitu Formasi Gumai, Formasi Air Benakat, Formasi Kasai, Andesit, serta Satuan Gunung Api Muda. Pola penyebaran batubara daerah penelitian berarah umum tenggara – barat laut, hal ini di karenakan pola penyebaran batubara didaerah penelitian masih berhubungan dengan hasil proses geologi regional yaitu adanya pola lipatan antiklin dan sinklin serta sesar mendatar sebagai pengendali utama pola penyebaran seam batubara di area penyelidikan, sedangkan estimasi sumberdaya batubara daerah penelitian yaitu 8.900.975,6 ton untuk sumberdaya tereka, 2.815.829,8 ton untuk sumberdaya tertunjuk, dan 854.850,8 ton untuk sumberdaya terukur, dengan total sumberdaya 12,571,656.1 ton. Batubara di daerah penelitian dijumpai pada bagian selatan daerah penelitian, dan untuk menentukan prospek atau tidaknya batubara didaerah penelitian harus dilakukan penelitian lebih lanjut, untuk mengetahui ketebalan dan penyebaran berdasarkan data bor, striping rasio, dan analisis kualitas batubara. Kata Kunci : cekungan sumatera selatan, estimasi sumber daya, pola penyebaran ABSTRACT The investigation area is in the Geramat area and its surroundings, South Merapi District, Lahat Regency, South Sumatra Province, including part of the South Sumatra Basin, which is estimated to contain quite a lot of coal because this basin is composed of lithology deposited in a terrestrial environment - transitional as part of the Muara Enim Formation. Other formations nearby, namely the Gumai Formation, Air Benakat Formation, Kasai Formation, Andesite, and the Young Volcano Unit. The coal distribution pattern in the research area has a general direction of southeast - northwest. This is because the coal distribution pattern in the research area is still related to the results of regional geological processes, namely the presence of anticline and syncline fold patterns and horizontal faults as the main controller of the coal seam distribution pattern in the investigation area. The projected coal resources for the research area are 8,900,975.6 tonnes inferred, 2,815,829.8 tonnes indicated, and 854,850.8 tonnes measured, for a total resource of 12,571,656.1 tonnes. Coal is found in the southern part of the research area, and more research is needed to determine thickness and distribution based on drill data, striping ratio, and coal quality analysis. Keywords: south sumatra basin, resource estimation, distribution patterns
The relationship between system inflammation response index and coronary heart disease: a cross-sectional study (NHANES 2007–2016)
Authors: Zhang Tian Yang , Chen Hai long , Shi Yanyu , Jin Ying , Zhang Yuan , Chen Ying 
Published: August 2024

BackgroundCoronary heart disease (CHD) is one of the common chronic diseases in clinical practice, often accompanied by inflammatory reactions. In recent years, the system inflammation response index (SIRI) has aroused researchers’ interest as a novel inflammatory biomarker. This study aims to explore the relationship between the SIRI and CHD through the National Health and Nutrition Examination Survey (NHANES) database.MethodsWe conducted a cross-sectional study and analyzed participants aged 40 and above with complete data from the NHANES survey years 2007–2016. Logistic regression analysis was used in this study to explore the relationship between the risk of CHD and SIRI. Stratified subgroup analysis was conducted based on age, gender, race, education level, body mass index (BMI), smoking status, drinking, hypertension, diabetes and angina pectoris to evaluate the relationship between SIRI and CHD in different populations. Additionally, restricted cubic spline (RCS) analysis was employed to investigate whether there is a nonlinear association between SIRI and CHD.ResultsA total of 6374 eligible participants were included, among whom 387 were diagnosed with CHD. The SIRI levels in the CHD group were significantly higher than those in the non-CHD group. After adjusting for potential confounders, an elevated SIRI level was associated with an increased risk of CHD, with an odds ratio of 1.12, 95% CI: (1.03, 1.22), P = 0.008. Subgroup analysis results indicated a significant interaction between SIRI and CHD among genders (P for interaction &lt;0.05), especially in females. In contrast, no significant interaction was observed among age, race, education level, BMI, smoking status, drinking, hypertension, diabetes and angina pectoris (P for interaction &gt;0.05). The RCS analysis showed a significant linear relationship between SIRI and CHD (P for non-linearity &gt;0.05), with an inflection point at 2.86.ConclusionOur study indicates that an elevated system inflammation response index is associated with a higher risk of CHD. Particularly among women.
Risk for progression to type 1 diabetes in first-degree relatives under 50 years of age
Authors: Urrutia Ines , Martinez Rosa , Calvo Begona , Marcelo Irene , Saso-Jimenez Laura , Martinez de Lapiscina Idoia , Bilbao Jose Ramon , Castano Luis , Rica Itxaso ,   The Collaborative Working Group
Published: August 2024

IntroductionThe detection of pancreatic autoantibodies in first-degree relatives of patients with type 1 diabetes (T1D) is considered a risk factor for disease. Novel available immunotherapies to delay T1D progression highlight the importance of identifying individuals at risk who might benefit from emerging treatments. The objective was to assess the autoimmunity in first-degree relatives of patients with T1D, estimate the time from autoimmunity detection to the onset of clinical diabetes, and identify the associated risk factors.MethodsRetrospective multicenter study of 3,015 first-degree relatives of patients with T1D recruited between 1992 and 2018. Pancreatic autoantibodies (IAA, GADA, IA2A, and ZnT8A) were determined by radioimmunoassay, starting the analyses at diagnosis of the proband. All those with positive autoimmunity and normal fasting blood glucose without clinical symptoms of diabetes were followed up in the study. The progression rate to T1D was assessed according to sex, relationship with the proband, age at autoimmunity detection, type/number of autoantibodies, and HLA-DRB1 genotype. Cox proportional-hazard models and Kaplan–Meier survival plots were used for statistical analyses.ResultsAmong the relatives, 21 progenitors [43.7 years (IQR: 38.1–47.7)] and 27 siblings [7.6 years (IQR: 5.8–16.1)] had positive autoantibodies. Of these, 54.2% (95% CI: 39.2%–68.6%) developed T1D (age at autoimmunity detection 11 months to 39 years) in a median of 5 years (IQR: 3.6–8.7; ranged from 0.9 to 22.6 years). Risk factors associated with faster progression to T1D were multiple autoimmunity and &lt;20 years at autoimmunity detection. Younger relatives (&lt;20 years) with multiple autoantibodies had a 5-year cumulative risk of developing diabetes of 52.9% (95% CI: 22.1%–71.6%) and a 20-year risk of 91.2% (95% CI: 50.5%–98.4%). The 20-year risk decreased to 59.9% (95% CI: 21.9%–79.5%) if only one risk factor was met and to 35.7% (95% CI: 0.0%–66.2%) if the relative was older than 20 years with one autoantibody.ConclusionsIn first-degree relatives with autoimmunity, the time to progression to T1D is faster in children and adolescents with multiple autoantibodies. Young adults are also at risk, which supports their consideration in screening strategies for people at risk of developing T1D.
Brain activation patterns in patients with post-stroke cognitive impairment during working memory task: a functional near-infrared spectroscopy study
Authors: Liu Yuanyuan , Zhong Zongye , Chen Jian , Kuo Hochieh , Chen Xiuli , Wang Ping , Shi Mingfang , Yang Mingzhen , Liu Bangzhong , Liu Guanghua 
Published: August 2024

ObjectiveTo explore the activation patterns in the frontal cortex of patients with post-stroke cognitive impairment during the execution of working memory tasks.Methods15 patients with post-stroke cognitive impairment, 17 patients without cognitive impairment, and 15 healthy controls of similar age and sex were included. All participants under-went immediate recall task testing and near-infrared spectroscopy imaging to measure frontal cortex activation during the task.ResultsThe healthy control group performed the best in the immediate recall task, followed by the post-stroke non-cognitive impairment group. The post-stroke cognitive impairment group had the poorest performance. The near-infrared spectroscopy results revealed that during the immediate recall task, the healthy control group primarily activated the left frontal lobe region. In contrast, post-stroke patients exhibited reduced activation in the left frontal lobe and increased activation in the right frontal cortex, particularly in the right frontopolar and orbitofrontal regions, with the post-stroke cognitive impairment group displaying the most pronounced changes.ConclusionPatients with post-stroke cognitive impairment exhibit reduced activation in the left prefrontal cortex during the working memory tasks. They rely on compensatory activation in the right prefrontal cortex, particularly in the frontopolar and orbitofrontal cortex, to successfully complete the task.
Effects of dexmedetomidine on early postoperative cognitive function and postoperative inflammatory response: a systematic review and network meta-analysis
Authors: Huang Cuifang , Yang Ruimin , Xie Xianlong , Dai Huijun , Pan Linghui 
Published: August 2024

BackgroundDexmedetomidine (DEX) has demonstrated potential as an effective agent for enhancing early postoperative cognitive function. However, there is ongoing debate regarding its optimal dosage and impact on early postoperative inflammatory response. This study aimed to assess and prioritize the effects of varying doses of DEX on early postoperative cognitive function and inflammatory response, in order to identify the most effective intervention dosage.MethodsRandomised controlled trials (RCTs) and retrospective cohort studies (RCS) from PubMed, Embase, and Cochrane Library up to January 28, 2024, were included. The Mini-Mental State Examination (MMSE) was utilized to assess the impact of varying doses of DEX on cognitive function during the early postoperative period as the primary outcome, peripheral blood levels of IL-6 and TNF-α were considered as secondary outcomes. Meta-analysis and Bayesian Network Meta-Analysis (NMA) were conducted using R. Funnel plots were generated using Stata 15.0.ResultsA total of 29 studies involving 2,807 patients and 25 different doses of DEX were included. DEX was given at a loading dose of 0.3–1.0 μg/kg followed by a maintenance dose of 0.1–0.5 μg/kg/h, or at a uniform intraoperative dose of 0.4–0.7 μg/kg/h. Network meta-analysis revealed most doses of DEX were significantly more effective than normal saline (NS) in improving postoperative MMSE scores (on days 1, 3, and 7) and lowering IL-6 and TNF-α levels. Probability results showed that a 1 μg/kg loading dose followed by a 0.6 μg/kg/h maintenance dose was the best dosing regimen for improving MMSE scores on postoperative days 1 (97.3%), 3 (100%), and 7 (99.9%), as well as for reducing postoperative blood IL-6 levels (1.3%). On the other hand, 0.3 μg/kg followed by 0.2 μg/kg/h was the optimal dosing regimen for reducing postoperative blood TNF-α levels (6.6%).ConclusionCompared with NS, intraoperative intravenous DEX improved early postoperative cognitive function and postoperative inflammatory response in patients undergoing elective surgery. In particular, a 1 μg/kg loading dose and a 0.6 μg/kg/h maintenance dose resulted in the best improvement in postoperative MMSE scores and blood IL-6 levels, while a 0.3 μg/kg loading dose followed by a 0.2 μg/kg/h maintenance dose is the optimal regimen for lowering postoperative blood TNF-α levels.Systematic review registration: https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=433932, identifier CRD42023433932.
Rosmarinus officinalis essential oil triggers depression followed by CNS excitability in Wistar rats
Authors: Bastos de Araújo Daniella , Raiol de Almeida Ysis Nayhara , Otake Hamoy Maria Klara , Vasconcelos de Souza Luana , Pacheco Hartcopff Priscille Fidelis , Gonçalves dos Santos Rodrigo , Santos da Silva Lívia Letícia , Lima da Rocha Lucas , Farias dos Santos Murilo , da Silva Deiga Yris , da Cunha Ferreira Rayllan , Vieira de Souza Raíssa , Barbosa Gabriela Brito , Hamoy Moisés 
Published: August 2024

The essential oil of rosemary (Rosmarinus officinalis) (EORO) is widely used in folk medicine and has proven therapeutic effects. Our research evaluated high doses of rosemary essential oil in 54 Wistar rats between 180 and 200 g. The study consisted of three experiments: 1) behavioral monitoring of the animals after administration of 500 mg/kg i.p.; 2) electrocorticographic records after drug administration; 3) anticonvulsant drug reaction, where phenytoin, phenobarbital, and diazepam 10 mg/kg i.p were applied. The results showed that the application of EORO presented two phases. Phase 1 was characterized by the appearance of myorelaxation and a reduction in the power of the electrocorticogram in low-frequency cerebral oscillations. Phase 2 was characterized by increased excitability, with the appearance of convulsions and the increased power of electrocorticographic recordings in cerebral oscillations up to 40 Hz. In this phase, three tracing patterns were observed. Beta oscillations were the most prevalent and were better controlled by diazepam, which demonstrates that the excitatory activity of EORO is related to the reduction of GABAergic activity.
No QTc prolongation with CDK 4/6 inhibitor FCN-437c: results of a concentration-QTc analysis from a dedicated study in adult healthy subjects
Authors: Zhao Lin , Sun Yi , Yang Xiaoran , Tian Ling , Li Lize , Wang Fangfang , Niu Xiaoye , Diao Lei , Li Haiyan 
Published: August 2024

Cardiotoxicity and QT interval prolongation have been a common cause of withdrawal of drugs from the market. FCN-437c is an oral, second-generation, potent, and selective CDK4/6 inhibitor for the treatment of patients with HR+/HER2- metastatic breast cancer. A single-center, double-blind, randomized, and placebo-controlled clinical study in healthy subjects was conducted to investigate the QTc prolongation potential of FCN-437c utilizing Concentration-QTc (C-QTc) modeling approach. FCN-437c was administered at doses of 300, and 400 mg with single oral administration, along with placebo, in 18 healthy subjects. Electrocardiograms (ECGs) through 24 h holter monitor and blood samples were collected. The Cmax of 400 mg single dose in healthy subjects is similar to that from therapeutic dose 200 mg QD at steady state in patients with cancer. The 90% CI upper limit of ΔΔQTcF at the Cmax geometric mean in both dose groups were &lt;10 ms. It is concluded that FCN-437c has low risk of prolonging the QT interval at therapeutic dose.Systematic Review Registration:https://clinicaltrials.gov/study/NCT06290466?term=NCT06290466&amp;rank=1, identifier [NCT06290466].