bluuebunny/crossref_metadata_2025_split huggingface dataset:
T‐DM1, a novel antibody–drug conjugate, is highly effective against primary HER2 overexpressing uterine serous carcinoma in vitro and in vivo
Authors: English Diana P. , Bellone Stefania , Schwab Carlton L. , Bortolomai Ileana , Bonazzoli Elena , Cocco Emiliano , Buza Natalia , Hui Pei , Lopez Salvatore , Ratner Elena , Silasi Dan‐Arin , Azodi Masoud , Schwartz Peter E. , Rutherford Thomas J. , Santin Alessandro D. 
Published: June 2014

AbstractAmplification of c‐erbB2 has been reported in over 30% of uterine serous carcinoma (USC) and found to confer poor survival because of high proliferation and increased resistance to therapy. In this study, we evaluated for the first time Trastuzumab emtansine (T‐DM1), a novel antibody–drug conjugate, against multiple epidermal growth factor receptor‐2 (HER2)‐positive USC cells in vitro followed by developing a supportive in vivo model. Fifteen primary USC cell lines were assessed by immunohistochemistry (IHC) and flow cytometry for HER2 protein expression. C‐erbB2 gene amplification was evaluated using fluorescent in situ hybridization. Sensitivity to T‐DM1 and trastuzumab (T)‐induced antibody‐dependent cell‐mediated cytotoxicity was evaluated in 5‐h chromium release assays. T‐DM1 and T cytostatic and apoptotic activities were evaluated using flow‐cytometry‐based proliferation assays. In vivo activity of T‐DM1 versus T in USC xenografts in SCID mice was also evaluated. High levels of HER2 protein overexpression and HER2 gene amplification were detected in 33% of USC cell lines. T‐DM1 was considerably more effective than trastuzumab in inhibiting cell proliferation and in causing apoptosis (P = 0.004) of USC showing HER2 overexpression. Importantly, T‐DM1 was highly active at reducing tumor formation in vivo in USC xenografts overexpressing HER2 (P = 0.04) and mice treated with TDM‐1 had significantly longer survival when compared to T‐treated mice and control mice (P ≤ 0.0001). T‐DM1 shows promising antitumor effect in HER2‐positive USC cell lines and USC xenografts and its activity is significantly higher when compared to T. T‐DM1 may represent a novel treatment option for HER2‐positive USC patients with disease refractory to trastuzumab and traditional chemotherapy.
Immune and Anticancer Responses Elicited by Fully Synthetic Aberrantly Glycosylated MUC1 Tripartite Vaccines Modified by a TLR2 or TLR9 Agonist
Authors: Abdel‐Aal Abu‐Baker M. , Lakshminarayanan Vani , Thompson Pamela , Supekar Nitin , Bradley Judy M. , Wolfert Margreet A. , Cohen Peter A. , Gendler Sandra J. , Boons Geert‐Jan 
Published: May 2014

AbstractThe mucin MUC1 is overexpressed and aberrantly glycosylated by many epithelial cancer cells manifested by truncated O‐linked saccharides. Although tumor‐associated MUC1 has generated considerable attention because of its potential for the development of a therapeutic cancer vaccine, it has been difficult to design constructs that consistently induce cytotoxic T‐lymphocytes (CTLs) and ADCC‐mediating antibodies specific for the tumor form of MUC1. We have designed, chemically synthesized, and immunologically examined vaccine candidates each composed of a glycopeptide derived from MUC1, a promiscuous Thelper peptide, and a TLR2 (Pam3CysSK4) or TLR9 (CpG‐ODN 1826) agonist. It was found that the Pam3CysSK4‐containing compound elicits more potent antigenic and cellular immune responses, resulting in a therapeutic effect in a mouse model of mammary cancer. It is thus shown, for the first time, that the nature of an inbuilt adjuvant of a tripartite vaccine can significantly impact the quality of immune responses elicited against a tumor‐associated glycopeptide. The unique adjuvant properties of Pam3CysSK4, which can reduce the suppressive function of regulatory T cells and enhance the cytotoxicity of tumor‐specific CTLs, are likely responsible for the superior properties of the vaccine candidate 1.
Exploring the Substrate Range of Wild‐Type Aminoacyl‐tRNA Synthetases
Authors: Fan Chenguang , Ho Joanne M. L. , Chirathivat Napon , Söll Dieter , Wang Yane‐Shih 
Published: May 2014

AbstractWe tested the substrate range of four wild‐type E. coli aminoacyl‐tRNA synthetases (AARSs) with a library of nonstandard amino acids (nsAAs). Although these AARSs could discriminate efficiently against the other canonical amino acids, they were able to use many nsAAs as substrates. Our results also show that E. coli tryptophanyl‐tRNA synthetase (TrpRS) and tyrosyl‐tRNA synthetase have overlapping substrate ranges. In addition, we found that the nature of the anticodon sequence of tRNATrp altered the nsAA substrate range of TrpRS; this implies that the sequence of the anticodon affects the TrpRS amino acid binding pocket. These results highlight again that inherent AARS polyspecificity will be a major challenge in the aim of incorporating multiple different amino acids site‐specifically into proteins.
Comparison of VEGF gene silencing efficiencies of chitosan and protamine complexes containing shRNA
Authors: Erdem‐Çakmak Fulden , Özbaş‐Turan Suna , Şalva Emine , Akbuğa Jülide 
Published: May 2014

AbstractVEGF is an angiogenic factor promoting the proliferation and migration of endothelial cells. Inhibition of VEGF by RNAi mechanism is one of the novel and the most important strategies in antiangiogenesis therapy. In this study, the tumor silencing efficiency of ternary complexes after addition of protamine to chitosan complexes containing VEGF targeting shRNA was investigated. Besides chitosan, protamine is an effective gene delivery material. Binary and ternary complexes consisting of chitosan, protamine, and shRNA were prepared to target VEGF, their morphology, size, and zeta potential of the complexes being measured. The average size of the complexes was between 173 and 284 nm and zeta potential was between +10 and 16 mV. In the ternary complexes, size decreased as the chitosan ratio increased; however, its molecular weight had no effect on the size of complexes. HeLa, HEK293, and MCF‐7 cell lines were used for in vitro transfection. VEGF was assayed by ELISA. A higher silencing effect was obtained using ternary complexes. Transgene expression was increased by adding protamine to chitosan complexes. Gene inhibition values in cell lines followed the rank HEK293>HeLa>MCF‐7. The addition of protamine to the chitosan/shRNA (VEGF) complexes increased the knockdown of VEGF genes in the cell lines, and no cytotoxicity was found after the complexes had been incorporated into the cells.
Response surface methodology for optimization of cyanamide analysis by in situ derivatization and dispersive liquid–liquid microextraction
Authors: Neves Junior Augusto C. V. , Melo Armindo , Pinho Carina , Coneglian Regina C. C. , Soares Antônio G. , Ferreira Isabel M. P. L. V. O. 
Published: May 2014

Cyanamide is widely used for agricultural purposes; therefore, its residues can be found in water. A new method was developed for its quantification using in situ derivatization with 2,6‐dimethyl‐4‐quinolinecarboxylic acid N‐hydroxysuccinimide ester followed by dispersive liquid–liquid microextraction (DLLME) and high‐performance liquid chromatography/fluorescence analysis. Multivariate chemometric techniques were successfully used to obtain the optimum conditions for direct derivatization and DLLME extraction. Derivatization parameters and DLLME extraction conditions were optimized by a two‐step design, 2k factorial design for screening, and central composite design for optimization. Best derivatization conditions were addition of 600 μL of derivatizing reagent, a temperature of 4 ºC, and pH 8.5, whereas for optimum extraction 800 μL of solvent, 30% NaCl conc. w/v, and pH 3.8 were chosen.The analytical performance of the method for routine analysis was evaluated. Excellent linearity was achieved from 10 to 200 µg L−1 with a correlation factor of 0.9996. Precision ranged from 3.5% to 5.5% for intraday assays and 8.5% to 8.6% for interday assays. The mean recoveries performed on water from different origins (ground, river, sea, tap, and mineral) at three levels of concentration (20, 75, and 200 µg L−1) ranged from 90.2% to 110.2%. Copyright © 2014 John Wiley & Sons, Ltd.
Azaphosphatrane Organocatalysts in Confined Space: Cage Effect in CO2 Conversion
Authors: Chatelet Bastien , Joucla Lionel , Dutasta Jean‐Pierre , Martinez Alexandre , Dufaud Véronique 
Published: May 2014

AbstractThe endohedral functionalization of a molecular cage by an azaphosphatrane unit has allowed for the creation of highly engineered catalytic cavities for efficient conversion of CO2 into cyclic carbonates. Strong structure/activity/stability correlations have been demonstrated by careful adjustment of the size, shape, and electronic properties of the hemicryptophane host.
Photochemistry of RuII 4,4′‐Bi‐1,2,3‐triazolyl (btz) Complexes: Crystallographic Characterization of the Photoreactive Ligand‐Loss Intermediate trans‐[Ru(bpy)(κ2‐btz)(κ1‐btz)(NCMe)]2+
Authors: Welby Christine E. , Armitage Georgina K. , Bartley Harry , Wilkinson Aaron , Sinopoli Alessandro , Uppal Baljinder S. , Rice Craig R. , Elliott Paul I. P. 
Published: May 2014

AbstractWe report the unprecedented observation and unequivocal crystallographic characterization of the meta‐stable ligand loss intermediate solvento complex trans‐[Ru(bpy)(κ2‐btz)(κ1‐btz)(NCMe)]2+ (1 a) that contains a monodentate chelate ligand. This and analogous complexes can be observed during the photolysis reactions of a family of complexes of the form [Ru($\widehat{NN}$)(btz)2]2+ (1 a–d: btz=1,1′‐dibenzyl‐4,4′‐bi‐1,2,3‐triazolyl; $\widehat{NN}$=a) 2,2′‐bipyridyl (bpy), b) 4,4′‐dimethyl‐2,2′‐bipyridyl (dmbpy), c) 4,4′‐dimethoxy‐2,2′‐bipyridyl (dmeobpy), d) 1,10‐phenanthroline (phen)). In acetonitrile solutions, 1 a–d eventually convert to the bis‐solvento complexes trans‐[Ru($\widehat{NN}$)(btz)(NCMe)2]2+ (3 a–d) along with one equivalent of free btz, in a process in which the remaining coordinated bidentate ligands undergo a new rearrangement such that they become coplanar. X‐ray crystal structure of 3 a and 3 d confirmed the co‐planar arrangement of the $\widehat{NN}$ and btz ligands and the trans coordination of two solvent molecules. These conversions proceed via the observed intermediate complexes 2 a–d, which are formed quantitatively from 1 a–d in a matter of minutes and to which they slowly revert back on being left to stand in the dark over several days. The remarkably long lifetime of the intermediate complexes (>12 h at 40 °C) allowed the isolation of 2 a in the solid state, and the complex to be crystallographically characterized. Similarly to the structures adopted by complexes 3 a and d, the bpy and κ2‐btz ligands in 2 a coordinate in a square‐planar fashion with the second monodentate btz ligand coordinated trans to an acetonitrile ligand.
α‐Cationic Phosphines: Synthesis and Applications
Authors: Alcarazo Manuel 
Published: May 2014

AbstractIn coordination chemistry, typical ancillary ligands are anionic or neutral species. Cationic ones are exceptions and, when used, the positively charged groups are normally attached to the periphery and not close to the donating atom. However, this concept article highlights a series of recent experimental, as well as theoretical results, suggesting that the utility in catalysis of cationic phosphines with no spacer between the phosphorus atom and the positively charged group(s) has been largely overlooked. In fact, a growing number of studies indicate that, because of their specific architecture, these cationic ligands depict excellent π‐acceptor character that can exceed that of phosphites or polyfluorinated phosphines. This property has been used to increase the Lewis acidity of the metals they coordinate. Specifically, new extreme π‐acid catalysts, mainly based on PtIIand AuI, have been recently prepared and their superior performance demonstrated along several mechanistically distinct transformations. In this concept article the current state of the art is critically assessed and possible future directions of the topic discussed.
Copper‐Catalyzed One‐Pot Denitrogenative–Dehydrogenative–Decarboxylative Coupling of β‐Ketoacids with Trifluorodiazoethane: Facile Access to Trifluoromethylated Aldol Products
Authors: Xiong Heng‐Ying , Yang Zhen‐Yan , Chen Zhen , Zeng Jun‐Liang , Nie Jing , Ma Jun‐An 
Published: May 2014

AbstractA novel copper‐catalyzed one‐pot cross‐coupling of β‐ketoacids with in situ generated trifluorodiazoethane has been developed. This reaction provides a direct and efficient method, in which one CC bond and one CO bond were formed in a carbenoid center with concomitant denitrogenation–dehydrogenation–decarboxylation, to afford trifluoromethylated aldol products. In several preliminary experiments, good to high enantioselectivities were also obtained.
Total Synthesis of 7‐ and 8‐Oxygenated Pyrano[3,2‐a]carbazole and Pyrano[2,3‐a]carbazole Alkaloids via Boronic Acid‐Catalyzed Annulation of the Pyran Ring
Authors: Julich‐Gruner Konstanze K. , Kataeva Olga , Schmidt Arndt W. , Knölker Hans‐Joachim 
Published: May 2014

AbstractThe boronic acid‐catalyzed annulation of citral opens up a short route to oxygenated cyclized monoterpenoid pyranocarbazole alkaloids. Thus, murrayamine‐D is available in only three steps and 55% overall yield from the corresponding carbazole precursor.
ChemInform Abstract: Giant Dielectric Response and Enhanced Thermal Stability of Multiferroic BiFeO3.
Authors: Lin Peng , Cui Simin , Zeng Xierong , Huang Haitao , Ke Shanming 
Published: June 2014

AbstractLarge‐scale fabrication of multiferroic BiFeO3 nanoparticles under ambient pressure is performed by precipitation of BiFe(CN)6·4H2O from an aq.
ChemInform Abstract: Porous Co3O4 Nanorods as Anode for Lithium‐Ion Battery with Excellent Electrochemical Performance.
Authors: Guo Jinxue , Chen Lei , Zhang Xiao , Chen Haoxin 
Published: June 2014

AbstractMesoporous Co3O4 nanorods as high performance anode for Li‐ion batteries are prepared by a two‐step approach comprising hydrothermal processing of CoCl2 and urea (autoclave, 100 °C, 12 h) followed by calcination in air (300 °C, 2 h).
ChemInform Abstract: KSbB2O6 and BaSb2B4O12: Novel Boroantimonates with 3D Anionic Architectures Composed of 1D Chains of SbO6 Octahedra and B2O5 Groups.
Authors: Huang Chao , Zhang Jian‐Han , Hu Chun‐Li , Xu Xiang , Kong Fang , Mao Jiang‐Gao 
Published: June 2014

AbstractSingle crystals of the title compounds are prepared by solid state reaction of K2CO3 or Ba(OH)2, Sb2O3, and H3BO3 (Pt crucibles, 850 °C, 33 h).
ChemInform Abstract: Na2Y3Cl3[TeO3]4: Synthesis, Crystal Structure and Spectroscopic Properties of the Bulk Material and Its Luminescent Eu3+‐Doped Samples.
Authors: Zitzer Sabine , Schleifenbaum Frank , Schleid Thomas 
Published: June 2014

AbstractColorless single crystals of the title compound are prepared by solid state reaction of Y2O3 and TeO2 in a molar ratio of 3:8 with an excess of NaCl as flux and reactant (silica ampule, Ar, 775 °C, 5 d).
ChemInform Abstract: Enantioselective Fluorination Reaction of β‐Ketoester‐Catalyzed Chiral Primary Amine‐Based Multifunctional Catalyst Systems.
Authors: Shang Jun‐Yan , Li Li , Lu Yixin , Yang Ke‐Fang , Xu Li‐Wen 
Published: June 2014

AbstractCombination of a cinchona alkaloid‐derived primary amine with L‐leucine gives a dual amine system with promising catalytic activity in enantioselective fluorination reactions of indanone‐2‐carboxylates (I).
ChemInform Abstract: Chiral Lewis Acid Catalyzed Asymmetric Cycloadditions of Disubstituted Ketenes for the Synthesis of β‐Lactones and δ‐Lactones.
Authors: Hao Xiaoyu , Liu Xiaohua , Li Wei , Tan Fei , Chu Yangyang , Zhao Xiaohu , Lin Lili , Feng Xiaoming 
Published: June 2014

AbstractAll reaction products are isolated with 98% diastereoisomeric excess.
ChemInform Abstract: Rare Earth Triflates/Chlorotrimethylsilane‐Promoted One‐Pot Synthesis of Enals.
Authors: Toyota Masahiro , Kagawa Natsuko , Sasaki Yoshiko , Sakaguchi Shoko , Nagatomo Ayumi , Kojima Hideo 
Published: June 2014

AbstractEt3N can be doubly activated by Tms‐Cl and various rare earth lanthanide triflates to become a protected acetaldehyde anion equivalent, which reacts with various heteroaromatic aldehydes to furnish the corresponding enals in moderate yields.
ChemInform Abstract: Studies Towards 1,3‐Diol Units Starting from syn β‐Hydroxy Acylsilanes.
Authors: PavanKumar Reddy Gangireddy , Srirama Murthy Akondi , Satyanarayana Reddy J. , Das Saibal , Roisnel Thierry , Yadav Jhillu S. , Chandrasekhar Srivari , Gree Rene 
Published: June 2014

AbstractSyn β‐hydroxy acylsilanes migrate to 1,3‐diols in the presence of fluoride anions.
ChemInform Abstract: Synthesis of Novel Zerumbone Derivatives via Regioselective Palladium Catalyzed Decarboxylative Coupling Reaction: A New Class of α‐Glucosidase Inhibitors.
Authors: Ajish K. R. , Dhanya B. P. , Joseph Nayana , Rani M. Priya , Raghu K. G. , Vineetha V. P. , Radhakrishnan K. V. 
Published: June 2014

AbstractA strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described.
ChemInform Abstract: A Chiral Sulfoxide‐Ligated Ruthenium Complex for Asymmetric Catalysis: Enantio‐ and Regioselective Allylic Substitution.
Authors: Trost Barry M. , Rao Meera , Dieskau Andre P. 
Published: June 2014

AbstractThis reaction proceeds with good regio‐ and enantioselectivity yielding preferably the branched products.
ChemInform Abstract: A Convenient Synthesis of Bisamides with BF3 Etherate as Catalyst.
Authors: Zhang Yi , Zhong Zhihao , Han Yingmei , Han Ruirui , Cheng Xu 
Published: June 2014

AbstractBF3‐catalyzed reaction of carboxylic amides with a variety of aldehydes allows the synthesis of bisamides under very mild reaction conditions.
ChemInform Abstract: Oxidation of Benzaldehydes to Benzoate Esters Using Household Bleach and Sodium Iodide in Alcohol Solvents.
Authors: Hathaway Bruce A. , DeKastle Christopher A. D. , Arnett Brianna A. 
Published: June 2014

AbstractPerforming the reaction in EtOH provides esters in yields comparable to those obtained in MeOH.
ChemInform Abstract: Diverse Modifications of the 4‐Methylphenyl Moiety of TAK‐779 by Late‐Stage Suzuki—Miyaura Cross‐Coupling.
Authors: Junker Anna , Schepmann Dirk , Yamaguchi Junichiro , Itami Kenichiro , Faust Andreas , Kopka Klaus , Wagner Stefan , Wuensch Bernhard 
Published: June 2014

AbstractA variety of new analogues of the potent and selective CCRS receptor antagonist TAK‐779 with increased oral bioavailability are synthesized.
ChemInform Abstract: Synthesis and Acylation of 3‐Aryl‐5‐(2‐phenylethynyl)‐4,5‐dihydro‐1H‐pyrazoles.
Authors: Odin I. S. , Golovanov A. A. , Bekin V. V. , Pisareva V. S. 
Published: June 2014

AbstractHydrazinolysis of ketones (I) in EtOH gives the title pyrazoles (II), which form stable N‐acyl derivatives (IV) with expected activity against mycobacteria.
ChemInform Abstract: Synthesis of New 1‐Substituted‐1H‐1,2,3,4‐tetrazoles from L‐α‐Amino Acids and Their Biological Assays.
Authors: Habibi Davood , Rahmani Payam , Ahmadi Fatemeh , Bokharaei Hanieh , Kaboudvand Zahra 
Published: June 2014

AbstractAcetic acid catalyzes the reaction between L‐α amino‐acids, triethyl orthoformate and sodium azide giving tetrazole products (III) in good yields.
ChemInform Abstract: Immobilization of 1,4‐Diazabicyclo[2.2.2]octane (DABCO) over Mesoporous Silica SBA‐15: An Efficient Approach for the Synthesis of Functionalized Spirochromenes.
Authors: Baharfar Robabeh , Azimi Razieh 
Published: June 2014

AbstractImmobilized DABCO appears to be an efficient heterogeneous catalyst for the synthesis of biologically active functionalized spirochromene derivatives via three‐component reaction of isatins/acenaphthoquinone with activated methylene reagents and 1,3‐dicarbonyl compounds in water.
ChemInform Abstract: Palladium‐Catalyzed Domino Protodecarboxylation/Oxidative Heck Reaction: Regioselective Arylation of Coumarin‐3‐carboxylic Acids.
Authors: Khoobi Mehdi , Molaverdi Fatemeh , Alipour Masoumeh , Jafarpour Farnaz , Foroumadi Alireza , Shafiee Abbas 
Published: June 2014

AbstractA simple catalyst system consisting of Pd(OAc)2 and 1,10‐phenanthroline is applied to give a wide range of different substituted coumarins without the need of a base or co‐catalyst.
ChemInform Abstract: A Facile Access to Polyfunctional Oxygen‐Containing Heterocycles via Intramolecularly Formed Protic Oxonium Ylide Trapping Processes.
Authors: Guo Xin , Liu Wei , Hu Wenhao 
Published: June 2014

AbstractIntramolecular trapping of oxonium ylides, generated by Cu‐catalyzed decomposition of diazoesters (I), with electron‐deficient aldehydes and isatins yields 3‐substituted 1,4‐dioxan‐2‐ones with high diastereoselectivity.
ChemInform Abstract: Synthesis of Thianthrene Derivatives Linked by Carbon Chains.
Authors: Sheikh Md. Chanmiya , Iwasawa Takasi , Nakajima Akitaka , Kitao Atsutaka , Tsubaki Noritatsu , Miyatake Ryuta , Yoshimura Toshiaki , Morita Hiroyuki 
Published: June 2014

AbstractThis describes the syntheses of several carbon‐chain‐linked thianthrene derivatives, e.
ChemInform Abstract: Structural Proof of Tetrazolo[1,5‐a]quinazoline Derivatives and Their Application in the Synthesis of 4‐Amino‐2‐(1,2,3‐triazol‐1‐yl)quinazolines.
Authors: Kalnina A. , Bizdena E. , Kiselovs G. , Mishnev A. , Turks M. 
Published: June 2014

Abstract2,4‐Diazidoquinazoline (I), which exists as an equilibrium mixture of azide and tetrazoles, reacts with amines (II) to furnish tetrazoloquinazolines (III).
ChemInform Abstract: 25th Anniversary Article: Semiconductor Nanowires — Synthesis, Characterization, and Applications
Authors: Dasgupta Neil P. , Sun Jianwei , Liu Chong , Brittman Sarah , Andrews Sean C. , Lim Jongwoo , Gao Hanwei , Yan Ruoxue , Yang Peidong 
Published: June 2014

AbstractReview: 350 refs.
Inhibitory Effects of Carvone Isomers on the GABAA Receptor in Primary Cultures of Rat Cortical Neurons
Authors: Sánchez‐Borzone Mariela , Delgado‐Marín Leticia , García Daniel A. 
Published: May 2014

ABSTRACTCarvone is a natural terpene which can be purified as R‐(−) or S‐(+) enantiomers. There are many reports about its antibacterial, antifungal, and insecticide activities, and also of some effects on the nervous system, where both enantiomers showed different potencies. Considering that the GABAA receptor is a major insecticide target, we studied the pharmacological activity of both carvone enantiomers, and of thujone as a reference compound acting on the receptor, on native GABAA by determining their effects on benzodiazepine recognition sites using primary neuronal cultures. Both isomers were able to inhibit the GABA‐induced stimulation of [3H]flunitrazepam binding, suggesting their interaction with the GABAA receptor as negative allosteric modulators. Their activity was comparable to that described for thujone in the present article, with the R‐(−)‐carvone being the more similar and potent stereoisomer. The different configuration of the isopropenyl group in position 5 thus seems to be significant for receptor interaction and the bicycle structure not to be critical for receptor recognition. The concentrations necessary to induce negative modulation of the receptor were not cytotoxic in a murine neuron culture system. These results confirm that, at least partially, the reported insecticidal activity of carvones may be explained by their interaction with the GABAA receptor at its noncompetitive blocker site. Chirality 26:368–372, 2014. © 2014 Wiley Periodicals, Inc.
Recent Advances in Chemical Process Optimization
Authors: Biegler Lorenz T. 
Published: May 2014

AbstractSystematic optimization strategies are essential in process design, operations and control. This study provides a concise overview of recent advances in process optimization, with a particular focus on nonlinear programming. Here, derivative‐free, SQP, reduced gradient, and interior point methods are described. Moreover, state of the art problem formulations and modeling environments are described, and contrasted with popular process simulation tools. Finally research directions are identified for future trends in multi‐scale optimization within large‐scale equation‐oriented optimization environments.