bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Microwave‐Assisted Efficient Synthesis of Aryl Thioethers Through C—H Functionalization of Arenes.
Authors: Liu Yi‐Chen , Lee Chin‐Fa 
Published: February 2014

AbstractThe sequential Ir‐catalyzed borylation followed by copper promoted C‐S bond formation gives access to aryl thioethers with excellent meta regioselectivity.
ChemInform Abstract: ZnO‐Mediated Regioselective C‐Arylsulfonylation of Indoles: A Facile Solvent‐Free Synthesis of 2‐ and 3‐Sulfonylindoles and Preliminary Evaluation of Their Activity Against Drug‐Resistant Mutant HIV‐1 Reverse Transcriptases (RTs).
Authors: Tocco Graziella , Begala Michela , Esposito Francesca , Caboni Pierluigi , Cannas Valeria , Tramontano Enzo 
Published: February 2014

AbstractMoreover, indoles and sulfonyl chlorides with strong electron withdrawing groups furnish the corresponding 2‐sulfinyl or 3‐sulfinyl indole derivatives.
ChemInform Abstract: Salicylaldoxime‐Functionalized Poly(ethylene glycol)‐Bridged Dicationic Ionic Liquid ([Salox‐PEG1000‐DIL][BF4]) as a Novel Ligand for Palladium‐Catalyzed Suzuki—Miyaura Reaction in Water.
Authors: Wang Yinglei , Luo Jun , Liu Zuliang 
Published: February 2014

AbstractThe catalytic system can be easily recovered and reused for at least five runs with only slight decrease in its activity.
ChemInform Abstract: Gallium(III) Triflate Catalyzed Diastereoselective Mukaiyama Aldol Reaction by Using Low Catalyst Loadings.
Authors: Plancq Baptiste , Justafort Lyse Carole , Lafantaisie Mathieu , Ollevier Thierry 
Published: February 2014

AbstractGa(OTf)3 is a safe and bench‐stable catalyst and act as a HOTf surrogate.
ChemInform Abstract: Facile One‐Pot Palladium‐Catalyzed Sequential Coupling to Diarylmethanes by Using Aryl Methyl Ketones as the Methylene Donors.
Authors: Wang Xing , Liu Lian‐Hua , Shi Jin‐Hua , Peng Ji , Tu Hai‐Yang , Zhang Ai‐Dong 
Published: February 2014

AbstractNo coupling product is obtained when aryl bromides are reacting with substrates bearing an active hydrogen such as in the amino‐ and hydroxy‐group.
ChemInform Abstract: Synthesis of Optically Pure 3,3′‐Diaryl Binaphthyl Disulfonic Acids via Stepwise N—S Bond Cleavage.
Authors: Hatano Manabu , Ozaki Takuya , Nishikawa Keisuke , Ishihara Kazuaki 
Published: February 2014

AbstractA practical synthesis of the title compounds in nine steps starting from binaphthyl (I) is developed.
ChemInform Abstract: Synthesis of 1,4‐Diarylfluorenone and 1,4‐Diarylfluorene.
Authors: Wang Yanmei , Liu Qiancai , Xiong Xiaoli , Deng Shiming , Zhang Jun , Zhu Min , Ge Hangmin 
Published: February 2014

AbstractStarting materials (I) are readily prepared by condensation of 1,3‐diarylacetones with ninhydrin.
ChemInform Abstract: Flexible and Practical Synthesis of Anthracenes Through Gold‐Catalyzed Cyclization of o‐Alkynyldiarylmethanes.
Authors: Shu Chao , Chen Cheng‐Bin , Chen Wei‐Xi , Ye Long‐Wu 
Published: February 2014

AbstractNotable features of this novel gold‐catalyzed hydroarylation process include tolerance of a wide range of functional groups, mild reaction conditions, simple procedure, and no need to avoid moisture or air.
ChemInform Abstract: Rhodium(III)‐Amine Dual Catalysis for the Oxidative Coupling of Aldehydes by Directed C—H Activation: Synthesis of Phthalides.
Authors: Tan Peng Wen , Juwaini Nur Asyikin Binte , Seayad Jayasree 
Published: February 2014

AbstractThe proposed reaction mechanism includes an initial ortho C—H activation followed by insertion and a final annulation step.
ChemInform Abstract: Asymmetric Synthesis of C2‐Symmetric Axially Chiral Biaryls Through Rhodium‐Catalyzed and Alkyne‐Controlled Diastereoselective Double [2 + 2 + 2] Cycloaddition.
Authors: Mori Ayaka , Araki Tatsuya , Miyauchi Yuta , Noguchi Keiichi , Tanaka Ken 
Published: February 2014

AbstractSignificant amounts (20‐45% NMR) of undesired regioisomers are also generated in some cases.
ChemInform Abstract: Gold‐Catalyzed Intramolecular Cyclization of Alkynones with Pyridine Anhydrobases.
Authors: Pawar Lokesh , Pigge F. Christopher 
Published: February 2014

AbstractAcylation of alkynone substrates followed by benzylic deprotonation produces anhydrobase intermediates which undergo endo‐dig cyclization to afford pyridyl substituted γ‐ and δ‐lactams.
ChemInform Abstract: Stereoselective Synthesis of 2,3‐Dihydropyrroles from Terminal Alkynes, Azides, and α,β‐Unsaturated Aldehydes via N‐Sulfonyl‐1,2,3‐triazoles.
Authors: Miura Tomoya , Tanaka Takamasa , Hiraga Kentaro , Stewart Scott G. , Murakami Masahiro 
Published: February 2014

AbstractThe N‐sulfonyl‐1,2,3‐triazoles [(I), (XI), and (XIII)] are prepared from terminal alkynes and azides by using a known procedure.
ChemInform Abstract: Transition‐Metal‐Catalyzed Regioselective Alkylation of Indoles with Alcohols.
Authors: Putra Anggi Eka , Takigawa Kei , Tanaka Hatsuki , Ito Yoshihiko , Oe Yohei , Ohta Tetsuo 
Published: February 2014

AbstractTwo sets of reaction conditions using Pd/C or RuCl2(PPh3)2/DPEphos as catalysts are developed for the C3‐alkylation of indoles with a variety of alcohols.
ChemInform Abstract: Nickel‐Catalyzed Decarbonylative Alkylidenation of Phthalimides with Trimethylsilyl‐Substituted Alkynes.
Authors: Shiba Takahiro , Kurahashi Takuya , Matsubara Seijiro 
Published: February 2014

AbstractBoth trimethylsilyl‐substituted alkynes and MAD are essential for the unusual transformation (decarbonylation/alkylidenation) with high selectivities.
ChemInform Abstract: Enantioselective Michael Addition of 1,3‐Diketones to Arenesulfonylalkylindoles: A Flexible Gateway to Optically Active 3‐sec‐Alkyl‐Substituted Indoles Containing a Pyrazole Skeleton.
Authors: Zuo Zongle , Zhang Shilu , Wang Rongming , He Wujun , Wu Song , Xie Xiaohua , Qin Dabin , Jing Linhai 
Published: February 2014

AbstractAlkylidene indolenines generated in situ from substrates (I) undergo enantioselective Michael addition with 1,3‐diketones.
ChemInform Abstract: Copper(I) Acetate‐Catalyzed Cycloaddition Between Azomethine Imines and Propiolates under Additive‐Free Conditions.
Authors: Shao Changwei , Zhang Qun , Cheng Guolin , Cheng Chuanjie , Wang Xinyan , Hu Yuefei 
Published: February 2014

AbstractA novel Cu(I)‐acetate catalyzed cycloaddition of azomethine imines (I) with activated terminal alkynes is described to give excellent yields of pyrazolo[1,2‐a]pyrazoles (III).
ChemInform Abstract: Facile Diastereoselective Synthesis of Functionally Enriched Hydantoins via Base‐Promoted Intramolecular Amidolysis of C‐3 Functionalized Azetidin‐2‐ones.
Authors: Mehra Vishu , Kumar Vipan 
Published: February 2014

AbstractThe reaction can also be conducted in the presence of DBU or KOtBu.
ChemInform Abstract: Unusual Mode of Reactivity of 2‐Alkylidene‐4‐oxothiazolidine S‐Oxides under the Pummerer Reaction Conditions.
Authors: Dzambaski Zdravko , Toljic Dorde , Bondzic Bojan , Markovic Rade , Baranac‐Stojanovic Marija 
Published: February 2014

AbstractThe reactivity of 2‐alkylidene‐4‐oxothiazolidine S‐oxides under Pummerer reaction conditions, using SOCl2, SOBr2, or Ac2O as initiators, is examined.
ChemInform Abstract: Ascorbic Acid Based Ionic Liquids: Recyclable and Efficient Catalytic Systems for the Huisgen Cycloaddition.
Authors: Koguchi Shinichi , Nakamura Kaori 
Published: February 2014

AbstractThe use of an ascorbic acid based ionic liquid as catalyst in combination with CuSO4 for the regioselective 1,3‐dipolar cycloaddition of organic azides to terminal alkynes is described.
ChemInform Abstract: Eco‐Friendly Synthesis of Tetrahydrobenzo[c]xanthenes Catalyzed by Functional Ionic Liquid in Water.
Authors: Yang Jiaojiao , Yang Jinming , Zhu Ting , Wang Pingping , Fang Dong 
Published: February 2014

AbstractA facile, environmentally benign synthesis of benzoxanthene derivatives (IV) and (VII) via a one‐pot multicomponent reaction of α‐naphthol, aromatic aldehydes and cyclic 1,3‐dicarbonyl compounds is developed.
ChemInform Abstract: Efficient, Stereodivergent Access to 3‐Piperidinols by Traceless P(OEt)3 Cyclodehydration.
Authors: Huy Peter H. , Koskinen Ari M. P. 
Published: February 2014

AbstractStereoselective routes towards both isomers of 2‐substituted 3‐piperidinols are developed, exploiting the I2/P(O—Et)3‐cyclodehydration for synthesis of cis‐piperidinols (II).
ChemInform Abstract: Enantioselective Synthesis of N‐Heterocycles via Intramolecular Pd(0)‐Catalyzed Allylic Amination.
Authors: Olszewska Beata , Kryczka Boguslaw , Zawisza Anna 
Published: February 2014

AbstractThe racemic and chiral synthesis of 2‐vinylpyrrolidines and 2‐vinylpiperidines under the employment of several chiral phosphorous ligands with moderate to good enantioselectivities is presented.
ChemInform Abstract: Pinacol Rearrangement of 3,4‐Dihydro‐3,4‐dihydroxyquinolin‐2(1H)‐ones: An Alternative Pathway to Viridicatin Alkaloids and Their Analogues.
Authors: Rudolf Ondrej , Rouchal Michal , Lycka Antonin , Klasek Antonin 
Published: February 2014

Abstractcis‐3,4‐Dihydroxyquinolin‐2‐ones (II) are subjected to the pinacol rearrangement, resulting in 4‐substituted 3‐hydroxyquinolin‐2‐ones (III).
ChemInform Abstract: Aerobic Multicomponent Tandem Synthesis of 3‐Sulfenylimidazo[1,2‐a]pyridines from Ketones, 2‐Aminopyridines, and Disulfides.
Authors: Ge Wenlei , Zhu Xun , Wei Yunyang 
Published: February 2014

AbstractThis protocol is also amenable to the preparation of 3‐selenated imidazopyridines and works even without the presence of a disulfide or diselenide giving high flexibility of the substituent in 3‐position.
ChemInform Abstract: One‐Pot Synthesis of 4‐Substituted 1H‐[1,2,3]Triazolo[4,5‐c]quinolines Through CuO‐Promoted Tandem Cyclization Reactions of (E)‐3‐(2‐Bromoaryl)‐1‐arylprop‐2‐en‐1‐ones with Sodium Azide.
Authors: Li Kangning , Chen Jinying , Li Jihui , Chen Yongxin , Qu Jinpeng , Guo Xin , Chen Chunxia , Chen Baohua 
Published: February 2014

AbstractCopper‐promoted tandem cyclization of 2‐bromoarylenones of type (I) with sodium azide offers a direct synthesis of triazoloquinolines (II).
ChemInform Abstract: An Efficient Ionic Liquid Mediated Synthesis of Substituted 5H[1,3]‐Thiazolo[2,3‐b]quinazoline‐3,5‐(2H)‐dione and 5H‐Thiazolo[2,3‐b]quinazolin‐5‐one.
Authors: Yadav Ashok K. , Dhakad Pankaj , Sharma Gopi Ram 
Published: February 2014

AbstractThe reaction is conducted under environmentally benign conditions.
ChemInform Abstract: A Convenient and Efficient Synthesis of Dipeptidyl Benzoxaboroles and Their Peptidomimetics.
Authors: Fu Zhengyan , He Jiangpeng , Tong Aiping , Xie Yongmei , Wei Yuquan 
Published: February 2014

AbstractPeptide couplings of benzoxaborole are achieved with need for protecting groups to afford dipeptidyl benzoxaboroles (III).
ChemInform Abstract: Palladium‐Catalyzed Direct C‐3 Oxidative Alkenylation of Phosphachromones.
Authors: Kang Dongjin , Cho Jaeyoung , Lee Phil Ho 
Published: February 2014

AbstractC‐3 alkenylated phosphachromones (III) are synthesized using a direct C‐3 alkenylation with activated and non‐activated alkenes (II) through C—H activation under aerobic conditions.
ChemInform Abstract: 2‐[(Acetyloxy)methyl]‐4‐(acetylsulfanyl)‐2‐(ethoxycarbonyl)‐3‐oxobutyl Group: A Thermolabile Protecting Group for Phosphodiesters.
Authors: Kiuru Emilia , Loennberg Harri , Ora Mikko 
Published: February 2014

AbstractThe potential of the protecting group in compound (IV) as an esterase‐ and thermolabile group is studied.
ChemInform Abstract: Structures and Absolute Configurations of Penicillactones A—C from an Endophytic Microorganism, Penicillium dangeardii Pitt.
Authors: Yu Shishan , et al. et al. 
Published: February 2014

AbstractCompounds II and III show inhibition of the release of β‐glucuronidase from polymorphonuclear leukocytes.
ChemInform Abstract: Sphenostylisins A—K: Bioactive Modified Isoflavonoid Constituents of the Root Bark of Sphenostylis marginata ssp. erecta.
Authors: Kinghorn A. Douglas , et al. et al. 
Published: February 2014

AbstractSphenostylisins A‐C (I), (II), and (III) are isolated from the title root bark together with eight additional new compounds (not shown).
ChemInform Abstract: Low‐Temperature Gasification of Biomass and Lignite: Consideration of Key Thermochemical Phenomena, Rearrangement of Reactions, and Reactor Configuration
Authors: Hayashi Jun‐ichiro , Kudo Shinji , Kim Hyun‐Seok , Norinaga Koyo , Matsuoka Koichi , Hosokai Sou 
Published: February 2014

AbstractReview: 179 refs.
Association between hypogonadism, symptom burden, and survival in male patients with advanced cancer
Authors: Dev Rony , Hui David , Del Fabbro Egidio , Delgado‐Guay Marvin O. , Sobti Nikhil , Dalal Shalini , Bruera Eduardo 
Published: February 2014

BACKGROUNDA high frequency of hypogonadism has been reported in male patients with advanced cancer. The current study was performed to evaluate the association between low testosterone levels, symptom burden, and survival in male patients with cancer.METHODSOf 131 consecutive male patients with cancer, 119 (91%) had an endocrine evaluation of total (TT), free (FT), and bioavailable testosterone (BT); high‐sensitivity C‐reactive protein (CRP); vitamin B12; thyroid‐stimulating hormone; 25‐hydroxy vitamin D; and cortisol levels when presenting with symptoms of fatigue and/or anorexia‐cachexia. Symptoms were evaluated by the Edmonton Symptom Assessment Scale. The authors examined the correlation using the Spearman test and survival with the log‐rank test and Cox regression analysis.RESULTSThe median age of the patients was 64 years; the majority of patients were white (85 patients; 71%). The median TT level was 209 ng/dL (normal: ≥ 200 ng/dL), the median FT was 4.4 ng/dL (normal: ≥ 9 ng/dL), and the median BT was 22.0 ng/dL (normal: ≥ 61 ng/dL). Low TT, FT, and BT values were all associated with worse fatigue (P ≤ .04), poor Eastern Cooperative Oncology Group performance status (P ≤ .05), weight loss (P ≤ .01), and opioid use (P ≤ .005). Low TT and FT were associated with increased anxiety (P ≤ .04), a decreased feeling of well‐being (P ≤ .04), and increased dyspnea (P ≤ .05), whereas low BT was only found to be associated with anorexia (P = .05). Decreased TT, FT, and BT values were all found to be significantly associated with elevated CRP and low albumin and hemoglobin. On multivariate analysis, decreased survival was associated with low TT (hazards ratio [HR], 1.66; P = .034), declining Eastern Cooperative Oncology Group performance status (HR, 1.55; P = .004), high CRP (HR, 3.28; P < .001), and decreased albumin (HR, 2.52; P < .001).CONCLUSIONSIn male patients with cancer, low testosterone levels were associated with systemic inflammation, weight loss, increased symptom burden, and decreased survival.A high frequency of hypogonadism has been reported in male patients with advanced cancer. In the current study, an increased symptom burden, systemic inflammation, weight loss, opioid use, and poor survival were found to be associated with decreased testosterone levels in male patients with cancer. Cancer 2014;120:1586–1593. © 2014 American Cancer Society.
Comparative analysis of 5 lung cancer natural history and screening models that reproduce outcomes of the NLST and PLCO trials
Authors: Meza Rafael , ten Haaf Kevin , Kong Chung Yin , Erdogan Ayca , Black William C. , Tammemagi Martin C. , Choi Sung Eun , Jeon Jihyoun , Han Summer S. , Munshi Vidit , van Rosmalen Joost , Pinsky Paul , McMahon Pamela M. , de Koning Harry J. , Feuer Eric J. , Hazelton William D. , Plevritis Sylvia K. 
Published: February 2014

BACKGROUNDThe National Lung Screening Trial (NLST) demonstrated that low‐dose computed tomography screening is an effective way of reducing lung cancer (LC) mortality. However, optimal screening strategies have not been determined to date and it is uncertain whether lighter smokers than those examined in the NLST may also benefit from screening. To address these questions, it is necessary to first develop LC natural history models that can reproduce NLST outcomes and simulate screening programs at the population level.METHODSFive independent LC screening models were developed using common inputs and calibration targets derived from the NLST and the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO). Imputation of missing information regarding smoking, histology, and stage of disease for a small percentage of individuals and diagnosed LCs in both trials was performed. Models were calibrated to LC incidence, mortality, or both outcomes simultaneously.RESULTSInitially, all models were calibrated to the NLST and validated against PLCO. Models were found to validate well against individuals in PLCO who would have been eligible for the NLST. However, all models required further calibration to PLCO to adequately capture LC outcomes in PLCO never‐smokers and light smokers. Final versions of all models produced incidence and mortality outcomes in the presence and absence of screening that were consistent with both trials.CONCLUSIONSThe authors developed 5 distinct LC screening simulation models based on the evidence in the NLST and PLCO. The results of their analyses demonstrated that the NLST and PLCO have produced consistent results. The resulting models can be important tools to generate additional evidence to determine the effectiveness of lung cancer screening strategies using low‐dose computed tomography. Cancer 2014;120:1713–1724. © 2014 American Cancer Society.
Cryptanalysis of smart‐card‐based password authenticated key agreement protocol for session initiation protocol of Zhang et al.
Authors: Jiang Qi , Ma Jianfeng , Tian Youliang 
Published: February 2014

SummaryAs the core signaling protocol for multimedia services, such as voice over internet protocol, the session initiation protocol (SIP) is receiving much attention and its security is becoming increasingly important. It is critical to develop a roust user authentication protocol for SIP. The original authentication protocol is not strong enough to provide acceptable security level, and a number of authentication protocols have been proposed to strengthen the security. Recently, Zhang et al. proposed an efficient and flexible smart‐card‐based password authenticated key agreement protocol for SIP. They claimed that the protocol enjoys many unique properties and can withstand various attacks. However, we demonstrate that the scheme by Zhang et al. is insecure against the malicious insider impersonation attack. Specifically, a malicious user can impersonate other users registered with the same server. We also proposed an effective fix to remedy the flaw, which remedies the security flaw without sacrificing the efficiency. The lesson learned is that the authenticators must be closely coupled with the identity, and we should prevent the identity from being separated from the authenticators in the future design of two‐factor authentication protocols. Copyright © 2014 John Wiley & Sons, Ltd.
Incident heart failure in relation to vascular disease: Insights from the Health, Aging, and Body Composition Study
Authors: Khan Hassan , Kalogeropoulos Andreas P. , Zannad Faiez , Marti Catherine N. , Wilson Peter W.F. , Georgiopoulou Vasiliki V. , Kanaya Alka M. , Newman Anne B. , Schelbert Erik , Harris Tamara B. , Kritchevsky Stephen , Yancy Clyde , Gheorghiade Mihai , Fonarow Gregg C. , Butler Javed ,   for the Health ABC Study
Published: February 2014

AimsThe contribution of heart failure (HF) unrelated to vascular disease to the overall HF burden in older adults is not well characterized. This was investigated in this study.Methods and resultsWe assessed HF incidence and outcomes in 2895 participants of the Health ABC Study (age 74 ± 3 years, 48.4% men, 41.4% black) in relation to vascular disease (coronary, peripheral, or cerebrovascular disease) either present at baseline or developed prior to HF. During 11.4 years follow‐up, 493 participants developed HF; 134 (27.2%) in participants without any prior vascular disease and 177 (36.8%) without coronary disease. Both baseline [hazard ratio (HR) 2.4, 95% confidence interval (CI) 1.9–2.8] and incident vascular disease (HR 4.3, 95% CI 3.6–5.2) were associated with HF. During a median follow‐up of 2.1 years after HF onset, 67.5% participants died. Annual mortality after HF development was 21.3% in those with compared with 24.6% in those without vascular disease (HR 1.11, 95% CI 0.87–1.43; P = 0.399). There were 658 all‐cause (436.3/1000 person‐years) and 523 HF‐related (346.4/1000 person‐years) hospitalizations after HF development. There was no significant difference in hospitalizations between those with and without vascular disease [rate ratio (RR) 1.04, 95% CI 0.86–1.24 for all‐cause, and RR 0.84 95% CI 0.69–1.02 for HF hospitalization]. HF with preserved EF was more common in participants without vascular disease (67.0% vs. 55.0%, P = 0.040).ConclusionA significant proportion of HF in older adults develops without prior vascular disease. Outcomes for these patients are poor compared with those with preceding vascular disease. These data suggest the need for more targeted HF prediction and prevention efforts.
1,3,2‐Diselena‐ and 1,3,2‐Ditelluraphospholanes with an Annelated 1,2‐Dicarba‐closo‐dodecaborane(12) Unit
Authors: Wrackmeyer Bernd , Klimkina Elena V. , Milius Wolfgang 
Published: February 2014

AbstractThe exchange reactions of phosphorus dihalides RPX2[R =iPr, cyclohexyl (Cy),tBu, (3,5‐Me2‐C6H3)CH2, Ph; X = Cl, Br], EtOPCl2, Et2NPCl2, Cl2PCH2PCl2, and Cl2PCH2CH2PCl2with 2,2‐dimethyl‐4,5‐[1,2‐dicarba‐closo‐dodecaborano(12)]‐1,3‐diselena‐2‐silacyclopentane provide a straightforward route to 1,3,2‐diselenaphospholanes. Some tellurium analogues were prepared from the dilithium salt [1,2‐(LiTe)2‐1,2‐C2B10H10] and were more difficult to characterize. For the selenium compounds, some of the P‐organosubstituted five‐membered rings dimerize to give ten‐membered rings, most readily with the more bulky alkyl groups such astBu. This was not observed for the tellurium compounds. The conformations of the five‐membered rings were studied by NMR spectroscopy and DFT methods. Striking structural differences were clear for the 2‐phenyl‐1,3,2‐diselenaphospholane derivative in solution and in the solid state. All reactions were monitored by multinuclear magnetic resonance spectroscopy (1H,11B,13C,31P,77Se, and125Te NMR), and solution‐state structures could be proposed. Remarkably large secondary isotope effects as isotope‐induced chemical shifts2Δ12/13C(31P) exerted by the carborane carbon atoms were observed; this is apparently a special property of the five‐membered ring. The gas‐phase structures were optimized by DFT methods [B3LYP/6‐311+G(d,p) level of theory], and the NMR parameters were calculated. Two 1,3,2‐diselenaphospholanes and one dimer were characterized by X‐ray analysis.
Guanidinium‐Based Artificial Receptors for Binding Orthophosphate in Aqueous Solution
Authors: Kataev Evgeny A. , Müller Christoph , Kolesnikov Grigory V. , Khrustalev Victor N. 
Published: February 2014

AbstractReceptors based on guanidinium‐ and pyrrole‐containing binding sites were designed and synthesized for selective recognition of orthophosphate in aqueous solution. Various analytical techniques were used to understand solution behavior and anion binding properties of the receptors in methanol and methanol/water mixtures. Binding studies revealed that the structure of pyrrole‐containing binding sites has great influence on selectivity of receptors for orthophosphate. The receptor with bulky substituents in the meso‐position of the dipyrrolylmethane core demonstrated the highest selectivity for orthophosphate over other inorganic anions.