bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary intraosseous mucoepidermoid carcinoma of the jaw: Reappraisal of The MD Anderson Cancer Center experience
Authors: Bell Diana , Lewis Carol , El‐Naggar Adel K. , Weber Randal S. 
Published: August 2015

AbstractBackgroundMucoepidermoid carcinoma arises from major or minor salivary glands, making up 10% of salivary gland tumors. Intraosseous mucoepidermoid carcinomas are rare, and make up only 2% to 3% of all mucoepidermoid carcinomas. The t(11;19) and its CRTC1‐MAML2 fusion gene transcript have been identified in mucoepidermoid carcinoma and are associated with a subset of mucoepidermoid carcinomas. The extent to which the transcript influences disease features and patient survival is unclear.MethodsWe conducted a retrospective analysis of records for clinical features, surgical interventions, and prognoses. Reverse transcriptase‐polymerase chain reaction (RT‐PCR) and fluorescence in situ hybridization (FISH) used to assess the t(11;19) fusion gene in intraosseous mucoepidermoid carcinoma.ResultsTwenty‐five patients with intraosseous mucoepidermoid carcinoma treated between 1998 and 2013 were identified. The t(11;19) fusion gene transcript CRTC1‐MAML2 manifested in 9 intraosseous mucoepidermoid carcinomas, whereas is was not detected in another 9 intraosseous carcinomas. Although the incidence of this fusion in mucoepidermoid carcinoma varies, it is generally accepted that more than 50% of this entity manifest the CRTC1‐MAML2.ConclusionIntraosseous mucoepidermoid carcinoma diagnosis should be based on clinical and pathologic manifestations and complete resection is the first choice for patient treatment. The need for neck dissection and adjuvant treatment are debatable. Radiotherapy may improve prognosis and may be recommended in the postoperative period. Primary intraosseous mucoepidermoid carcinoma can manifest the fusion transcript in a subset of tumors. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1312–E1317, 2016
Facile Rh‐C Bond Cleavage of Rhodium(III) Benzyl Porphyrin Complex in DMSO with Strong Bases
Authors: Wang Zikuan , Yin Haolin , Yun Lin , Liu Xu , Fu Xuefeng 
Published: August 2015

AbstractRhodium‐carbon bond cleavage represents an essential step for small molecule activation and transformation by rhodium porphyrin complexes. This article reports on a new method for the cleavage of porphyrin rhodium(III)‐carbon bonds in DMSO solvent with strong bases. UV‐Vis, in situ 1H NMR spectrum and GC‐MS analysis confirmed generation of rhodium(I) species and monodeuterated toluene. Mechanistic studies revealed that strongly reducing CD3SOCD2−, formed in situ from DMSO‐d6 and strong bases, promoted Rh‐C bond cleavage.
A Case for Mechanisms
Authors: Künzi Stefan A. , Sarria Toro Juan Manuel , den Hartog Tim , Chen Peter 
Published: August 2015

AbstractA case study in the (re)discovery of a non‐diazo, catalytic, electrophilic cyclopropanation reaction is presented to illustrate the role of mechanistic concepts in chemical innovation. The specific instance also highlights how specific personalities interacted in the report, retraction, and reconsideration of a novel methylene transfer reaction. The case study ends with a series of lessons learned, which generalize the findings from the specific case.
The integration of talent management practices and computer aided engineering in new product development
Authors: Louw Wynand J. , Benade Siebert 
Published: August 2015

AbstractIt is commonly perceived that computer aided engineering (CAE) tools have the potential of improving the quality of products and the time and cost performance of new product development (NPD) undertakings. Whilst the effect of CAE usage on NPD performance is the subject of numerous literature articles, the reasons for its failure to achieve the expected NPD improvements are seldom investigated. A gap in the theory thus exists as speculative reasons are provided where research has found statistically insignificant or negative correlation between NPD performance and CAE usage. The objective of this research was to determine if CAE tool usage has a greater positive impact on NPD performance when combined with talent management initiatives, since talent development presents itself as a possible enabler to realise the potential CAE performance gains. An exploratory multiple case study research strategy was followed where semi‐structured interviews were conducted with individuals at three NPD companies. The results show that satisfying talent requirements is indeed an enabling factor to gain advantage from CAE tools, and talent requirements of NPD managers and engineers are identified.
Modelling Methodology for Engineering of Complex Sociotechnical Systems
Authors: Oosthuizen Rudolph , Pretorius Leon 
Published: August 2015

AbstractDifferent Systems Engineering techniques and approaches are applied to design and develop complex sociotechnical systems for complex problems. In a complex sociotechnical system cognitive and social humans use information technology to make sense of a situation in support of decisions. The complex dynamic system elements, their interaction and, the complex environment make sociotechnical systems difficult to develop. A modelling and assessment methodology in support of the Systems Engineering process is required to understand the sociotechnical system's behaviour and underlying structure. It must capture the dynamic interaction as well as the effect of humans performing work in a complex environment. Cognitive Work Analysis and System Dynamics are two complementary approaches that can be applied in support of each other within this context.
Hybrid and Blended Learning
Authors: O'Byrne W. Ian , Pytash Kristine E. 
Published: August 2015

AbstractHybrid or blended learning is defined as a pedagogical approach that includes a combination of face‐to‐face instruction with computer‐mediated instruction. The terms blended learning, hybrid learning, and mixed‐mode learning are used interchangeably in current research; however, in the United States, hybrid learning is used most often. Although hybrid learning can be diverse in how it is implemented, educators agree that this approach has the opportunity to provide personalized instruction with some element of student control over path, pace, time, and place. Educators and students need to be given the latitude to teach and learn in these hybrid spaces while being protected and supported by schools. Ultimately, teachers and students bear an equal responsibility as they collaboratively learn and experiment in these evolving spaces.
Degradation of polypropylene in vivo: A microscopic analysis of meshes explanted from patients
Authors: Iakovlev Vladimir V. , Guelcher Scott A. , Bendavid Robert 
Published: August 2015

AbstractPolypropylene meshes, originally introduced for hernia repair, are presently utilized in several anatomical sites. Several million are implanted annually worldwide. Depending on the device, up to 10% will be excised to treat complications. The excised meshes can provide material to study the complications, however, they have remained underutilized over the last decades and the mechanisms of complications continue to be incompletely understood. The fundamental question as to whether polypropylene degrades in vivo is still debated. We have examined 164 excised meshes using conventional microscopy to search for features of polypropylene degradation. Four specimens were also examined by transmission electron microscopy. The degraded material, detected by its ability to absorb dyes in the degradation nanopores, formed a continuous layer at the surface of the mesh fibers. It retained birefringence, inclusions of non‐degraded polypropylene, and showed ability to meld with the non‐degraded fiber core when heated by the surgical cautery. Several features indicated that the degradation layer formed in vivo: inflammatory cells trapped within fissures, melting caused by cautery of excision surgery, and gradual but progressive growth of the degradation layer while in the body. Cracking of the degraded material indicated a contribution to clinically important mesh stiffening and deformation. Chemical products of degradation need to be analyzed and studied for their role in the mesh‐body interactions. The described methods can also be used to study degradation of other materials. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 105B: 237–248, 2017.
In vivo assessment of two endothelialization approaches on bioprosthetic valves for the treatment of chronic deep venous insufficiency
Authors: Glynn Jeremy J. , Jones Casey M. , Anderson Deirdre E.J. , Pavcnik Dusan , Hinds Monica T. 
Published: August 2015

AbstractChronic deep venous insufficiency is a debilitating disease with limited therapeutic interventions. A bioprosthetic venous valve could not only replace a diseased valve, but has the potential to fully integrate into the patient with a minimally invasive procedure. Previous work with valves constructed from small intestinal submucosa (SIS) showed improvements in patients' symptoms in clinical studies; however, substantial thickening of the implanted valve leaflets also occurred. As endothelial cells are key regulators of vascular homeostasis, their presence on the SIS valves may reduce the observed thickening. This work tested an off‐the‐shelf approach to capture circulating endothelial cells in vivo using biotinylated antikinase insert domain receptor antibodies in a suspended leaflet ovine model. The antibodies on SIS were oriented to promote cell capture and showed positive binding to endothelial cells in vitro; however, no differences were observed in leaflet thickness in vivo between antibody‐modified and unmodified SIS. In an alternative approach, valves were pre‐seeded with autologous endothelial cells and tested in vivo. Nearly all the implanted pre‐seeded valves were patent and functioning; however, no statistical difference was observed in valve thickness with cell pre‐seeding. Additional cell capture schemes or surface modifications should be examined to find an optimal method for encouraging SIS valve endothelialization to improve long‐term valve function in vivo. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1610–1621, 2016.
Connectivity among subpopulations of louisiana black bears as estimated by a step selection function
Authors: Clark Joseph D. , Laufenberg Jared S. , Davidson Maria , Murrow Jennifer L. 
Published: August 2015

ABSTRACTHabitat fragmentation is a fundamental cause of population decline and increased risk of extinction for many wildlife species; animals with large home ranges and small population sizes are particularly sensitive. The Louisiana black bear (Ursus americanus luteolus) exists only in small, isolated subpopulations as a result of land clearing for agriculture, but the relative potential for inter‐subpopulation movement by Louisiana black bears has not been quantified, nor have characteristics of effective travel routes between habitat fragments been identified. We placed and monitored global positioning system (GPS) radio collars on 8 female and 23 male bears located in 4 subpopulations in Louisiana, which included a reintroduced subpopulation located between 2 of the remnant subpopulations. We compared characteristics of sequential radiolocations of bears (i.e., steps) with steps that were possible but not chosen by the bears to develop step selection function models based on conditional logistic regression. The probability of a step being selected by a bear increased as the distance to natural land cover and agriculture at the end of the step decreased and as distance from roads at the end of a step increased. To characterize connectivity among subpopulations, we used the step selection models to create 4,000 hypothetical correlated random walks for each subpopulation representing potential dispersal events to estimate the proportion that intersected adjacent subpopulations (hereafter referred to as successful dispersals). Based on the models, movement paths for males intersected all adjacent subpopulations but paths for females intersected only the most proximate subpopulations. Cross‐validation and genetic and independent observation data supported our findings. Our models also revealed that successful dispersals were facilitated by a reintroduced population located between 2 distant subpopulations. Successful dispersals for males were dependent on natural land cover in private ownership. The addition of hypothetical 1,000‐m‐ or 3,000‐m‐wide corridors between the 4 study areas had minimal effects on connectivity among subpopulations. For females, our model suggested that habitat between subpopulations would probably have to be permanently occupied for demographic rescue to occur. Thus, the establishment of stepping‐stone populations, such as the reintroduced population that we studied, may be a more effective conservation measure than long corridors without a population presence in between. Published 2015. This article is a U.S. Government work and is in the public domain in the USA.
Behavioral effects of an immunocontraceptive vaccine on eastern fox squirrels
Authors: Krause Sara K. , Van Vuren Dirk H. , Laursen Clara , Kelt Douglas A. 
Published: August 2015

ABSTRACTManaging pest species in urban and suburban areas is challenging, and contraception may provide a socially acceptable and effective management option for many species. The immunocontraceptive vaccine, GonaCon, effectively inhibits reproduction in many species of wildlife, but the behavioral effects are not yet well understood. Contraceptive‐induced changes in behavior could raise animal welfare concerns and alter survival and reproductive rates in populations. These vital rates frequently are incorporated in population models to predict the population‐level efficacy of contraception. Thus, understanding the behavioral impacts of contraception is necessary to accurately predict population‐level effectiveness of contraception and to protect animal welfare. We investigated the behavioral effects of GonaCon on eastern fox squirrels (Sciurus niger), a pest species that has invaded much of the western United States, caused widespread damages to human infrastructure, and threatened native western gray squirrels (S. griseus). We used field observations to measure time‐activity budgets and dominance, open field trials to measure exploratory behavior, and mirror image stimulation to measure aggression because GonaCon could alter these behaviors. Contrary to our predictions, we failed to detect any significant effects of GonaCon on any of these behaviors. Our results, combined with a previous study finding that GonaCon is highly effective at inhibiting reproduction in fox squirrels, indicate that GonaCon may be a viable control method for fox squirrels and that behavioral changes affecting the demographic parameters are unlikely to undermine population models used to predict the effectiveness of GonaCon. © 2015 The Wildlife Society.
From Slope Morphometry to Morphogenetic Processes: An Integrated Approach of Field Survey, Geographic Information System Morphometric Analysis and Statistics in Italian Badlands
Authors: Cappadonia Chiara , Coco Laura , Buccolini Marcello , Rotigliano Edoardo 
Published: August 2015

AbstractCalanchi (singular: calanco) represent a typical example of badlands in the Italian peninsula, which rapidly evolve on clayey terrains such as the widespread Pliocene–Pleistocene marine clays. The present study aimed at investigating the role of the slope morphometry on the typology and distribution of morphogenetic processes in a calanchi area located in southern Italy. The research included detailed geomorphological surveying as well as morphometric and statistical analyses. The study area was first subdivided into individual hydrographic units (HUs), for which field survey allowed to identify the dominant denudation processes, their intensity and the distribution of the associated landforms (pipes, rills, gullies and landslides). The morphometry of each HU was characterised by calculating the morphometric slope index (MSI) on a reconstructed digital elevation model. By statistically comparing the morphogenetic and morphometric data, the influence of the slope morphometry on the type, distribution and evolution of the calanchi erosion process has been highlighted. In particular, through a cluster analysis, the groups of HUs having similar dominant processes were identified, and by applying the analysis of variance, the effect of the MSI on the identified clusters was analysed. Two clusters were identified, which revealed the relative importance of morphogenetic processes and the strict connection between surface and subsurface landforms. These two clusters were discriminated by the MSI value (high MSI favoured mass movements, while low MSI favoured gully erosion and piping), highlighting the importance of slope morphometry in driving the morphogenetic hillslope processes. Copyright © 2015 John Wiley & Sons, Ltd.
Prediction of Nucleotide Binding Peptides Using Star Graph Topological Indices
Authors: Liu Yong , Munteanu Cristian R. , Fernández Blanco Enrique , Tan Zhiliang , Santos del Riego Antonino , Pazos Alejandro 
Published: August 2015

AbstractThe nucleotide binding proteins are involved in many important cellular processes, such as transmission of genetic information or energy transfer and storage. Therefore, the screening of new peptides for this biological function is an important research topic. The current study proposes a mixed methodology to obtain the first classification model that is able to predict new nucleotide binding peptides, using only the amino acid sequence. Thus, the methodology uses a Star graph molecular descriptor of the peptide sequences and the Machine Learning technique for the best classifier. The best model represents a Random Forest classifier based on two features of the embedded and non‐embedded graphs. The performance of the model is excellent, considering similar models in the field, with an Area Under the Receiver Operating Characteristic Curve (AUROC) value of 0.938 and true positive rate (TPR) of 0.886 (test subset). The prediction of new nucleotide binding peptides with this model could be useful for drug target studies in drug development.
Enhancement of effective area of Bragg waveguide using plasma for communication systems
Authors: Srivastava Vivek K. , Prajapati Yogendra K. , Singh Vivek , Saini Jai P. 
Published: August 2015

ABSTRACTAn efficient study is performed to modify the propagation characteristics of Bragg waveguide using plasma filled core. The proposed Bragg waveguide consists of a low index central region having plasma surrounded by a large number of periodic cladding layers of dielectric with alternating high and low refractive indices. The effect of plasma filled core of proposed waveguide on chromatic dispersion, radiation loss, and effective area is studied. This analysis shows that introducing plasma in the core region of proposed waveguide is a key to achieve higher effective area with small radiation loss. Hence, a trade‐off exists between low radiation loss and high effective area in the proposed waveguide. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2491–2496, 2015
A new analytical technique for extraction of bias‐dependent drain resistance in GaAs and GaN HEMTs
Authors: Kokolov A. A. , Babak L. I. 
Published: August 2015

ABSTRACTTo improve the quality of transistor modeling, the nonlinear behavior of each element of the equivalent circuit must be known. There are few works devoted to the extraction of bias‐dependent drain resistance Rd, which strongly affects the transistor modeling. In this work, a new analytical technique for the extraction of bias‐dependent drain resistance in HEMT small signal model (SSM) is proposed. The efficiency of the new technique is demonstrated for GaN and GaAs HEMTs. It is shown that the new approach leads to the better SSM accuracy in the range of DC biases as compared to the widespread extraction methods. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2536–2539, 2015
Investigation on cellular‐automata irregular‐fractal ultrawideband slot‐antennas
Authors: Ladhar Lotfi , Zarouan Mohamed , Oueslati Donia , Floch Jean‐Marie , Rmili Hatem 
Published: August 2015

ABSTRACTIn this article, the effect of an irregular‐fractal slot added to a radiating square patch of an ultrawideband (UWB) printed antenna is studied. The fractal complex‐shaped slot was generated randomly by applying the Cellular‐Automata technique. Analysis of both simulated and measured results dealing with the impedance matching, surface currents, gain, and radiation patterns shows three different behaviors: improvement, mismatching, or rejection of one or two bands, depending on the shape and position of the slot. It is found also that the gain of the UWB‐antenna can be enhanced for some particular shaped slots. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2506–2514, 2015
Fault location for WDM‐PON using a multiple‐longitudinal‐mode laser modulated by chaotic wave
Authors: Xu Hang , Wang Bingjie , Zhang Jianguo , Han Hong , Liu Li , Wang Yuncai , Wang Anbang 
Published: August 2015

ABSTRACTWe experimentally demonstrate a cost‐effective method to locate faults in wavelength‐division‐multiplexing passive optical network (WDM‐PON) utilizing a multiple‐longitudinal‐mode Fabry–Perot semiconductor laser directly modulated by chaotic wave from a Colpitts oscillator. Due to chaos modulation, every longitudinal mode of the laser has chaotic intensity waveform. Using a tunable optical filter selects a mode to detect the wavelength‐matched branch of WDM‐PON using chaos correlation technique. Experimental results show that the unterminated fiber end, mismatch connector and fiber breakpoint can be preciously located. A detection range of approximately 75 km and a range‐independent spatial resolution of 14 cm are achieved. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2502–2506, 2015
A three‐phase PMOS voltage‐controlled oscillator using ring and triple‐push coupling
Authors: Jang Sheng‐Lyang 
Published: August 2015

ABSTRACTThis letter presents a three‐phase VCO consisted of three identical single‐ended Clapp pMOSFET VCOs coupled by a pMOSFET ring and tail inductors. The three‐phase circuit operation is based on the interaction of frequency tripler and divide‐y‐3 injection‐locked frequency divider in addition to the MOSFET‐ring coupling. The fully integrated 8.5 GHz three‐phase VCO was fabricated in 90 nm CMOS process, the frequency tuning range is from 8.08 to 8.94 GHz and the VCO‐core power consumption is 4.04 mW at the supply voltage of 0.88 V. The measured phase noise is −117.18 dBc/Hz at 1 MHz offset frequency from the carrier frequency 8.822 GHz. The VCO occupies a chip area of 0.864 × 0.76 mm2 and provides a figure of merit of −190.1 dBc/Hz. The phase noise is reduced through optimizing capacitor value in the Colpitts negative resistance cell. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2529–2532, 2015
A novel hexagonal wideband circularly polarized stacked patch microstrip antenna
Authors: Mondal Tapas , Samanta Susamay , Ghatak Rowdra , Chaudhuri Sekhar Ranjan Bhadra 
Published: August 2015

ABSTRACTThis article proposes a novel, simple, microstrip‐fed, circularly polarized, stacked, diagonal‐slotted, wideband hexagonal microstrip patch antenna for Intelligent Transport System (ITS) applications. It has been found to operate in the Global Positioning Systems frequency L1 (GPS 1.575 GHz). The fabricated antenna shows an impedance bandwidth of 171 MHz which is around 11% (1.521–1.692 GHz) with 3 dB axial‐ratio‐bandwidth (ARBW) of 80 MHz which is around 5% (1.54–1.62 GHz) and for the entire 3 dB ARBW the gain achieved is over 6.5 dBi. © 2015 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:2548–2554, 2015