bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-term ileoanal pouch survival after pouch urinary tract fistulae
Authors: Uchino T. , Lincango E. P. , Lavryk O. , Lipman J. , Wood H. , Angermeier K. , Steele S. R. , Hull T. L. , Holubar S. D. 
Published: June 2024

Abstract
Background
Ileoanal pouch is a demanding procedure with many potential technical complications including bladder or ureteral injury, while inflammation or stricture of the anastomosis or anal transition zone may lead to the formation of strictures and fistulae, including to the adjacent urethra. Pouch urinary tract fistulae are rare. We aimed to describe the presentation, diagnostic workup, and management of patients with pouch urinary at our center.

Methods
Our prospectively maintained pouch registry was queried using diagnostic codes and natural language processing free-text searches to identify ileoanal pouch patients diagnosed with any pouch-urinary tract fistula from 1997 to 2022. Descriptive statistics and pouch survival using Kaplan–Meier curves are presented. Numbers represent frequency (proportion) or median (range).

Results
Over 25 years, urinary fistulae were observed 27 pouch patients; of these, 16 of the index pouches were performed at our institution [rate 0.3% (16/5236)]. Overall median age was 42 (27–62) years, and 92.3% of the patients were male. Fistula locations included pouch-urethra in 13 patients (48.1%), pouch-bladder in 12 patients (44.4%), and anal-urethra in 2 (7.4%). The median time from pouch to fistula was 7.0 (0.3–38) years. Pouch excision and end ileostomy were performed in 12 patients (bladder fistula, n = 3; urethral fistula, n = 9), while redo ileal pouch-anal anastomosis (IPAA) was performed in 5 patients (bladder fistula, n = 3; urethral fistula, n = 2). The 5-year overall pouch survival after fistula to the bladder was 58.3% vs. 33.3% with urethral fistulae (p = 0.25).

Conclusion
Pouch-urinary tract fistulae are a rare, morbid, and difficult to treat complication of ileoanal pouch that requires a multidisciplinary, often staged, surgical approach. In the long term, pouches with bladder fistulae were more likely to be salvaged than pouches with urethral fistulae.
Identification of lipid metabolism-related gene signature in the bone marrow microenvironment of multiple myelomas through deep analysis of transcriptomic data
Authors: Feng Dan , Wang Zhen , Cao Shengji , Xu Hui , Li Shijun 
Published: June 2024

AbstractDysregulated lipid metabolism in the bone marrow microenvironment (BMM) plays a vital role in multiple myeloma (MM) development, progression, and drug resistance. However, the exact mechanism by which lipid metabolism impacts the BMM, promotes tumorigenesis, and triggers drug resistance remains to be fully elucidated.By analyzing the bulk sequencing and single-cell sequencing data of MM patients, we identified lipid metabolism-related genes differential expression significantly associated with MM prognosis, referred to as LMRPgenes. Using a cohort of ten machine learning algorithms and 117 combinations, LMRPgenes predictive models were constructed. Further exploration of the effects of the model risk score (RS) on the survival status, immune status of patients with BMM, and response to immunotherapy was conducted. The study also facilitated the identification of personalized therapeutic strategies targeting specified risk categories within patient cohorts.Analysis of the scRNA-seq data revealed increased lipid metabolism-related gene enrichment scores (LMESs) in erythroblasts and progenitor, malignant, and Tprolif cells but decreased LMESs in lymphocytes. LMESs were also strongly correlated with most of the 50 hallmark pathways within these cell populations. An elevated malignant cell ratio and reduced lymphocytes were observed in the high LMES group. Moreover, the LMRPgenes predictive model, consisting of 14 genes, showed great predictive power. The risk score emerged as an independent indicator of poor outcomes. Inverse relationships between the RS and immune status were noted, and a high RS was associated with impaired immunotherapy responses. Drug sensitivity assays indicated the effectiveness of bortezomib, buparlisib, dinaciclib, staurosporine, rapamycin, and MST-312 in the high-RS group, suggesting their potential for treating patients with high-RS values and poor response to immunotherapy. Ultimately, upon verification via qRT-PCR, we observed a significant upregulation of ACBD6 in NDMM group compared to the control group.Our research enhances the knowledge base regarding the association between lipid metabolism-related genes (LMRGs) and the BMM in MM patients, offering substantive insights into the mechanistic effects of the BMM mediated by LMRGs.
Graphical abstract
Morphological and functional evolution of gametophytes in epilithic Hymenasplenium murakami-hatanakae (Aspleniaceae): The fifth family capable of producing the independent gametophytes
Authors: Yoneoka Katsuhiro , Fujiwara Tao , Kataoka Toshifumi , Hori Kiyotaka , Ebihara Atsushi , Murakami Noriaki 
Published: June 2024

AbstractThe fern independent gametophytes that can maintain populations by vegetative reproduction without conspecific sporophytes have been considered an unusual phenomenon found in some epiphytic or epilithic species of Hymenophyllaceae, Pteridaceae, Lomariopsidaceae, and Polypodiaceae. By chance, the discovery of mysterious strap-like gametophytes on Izu-Oshima Island, Japan, has led to the hypothesis that Hymenasplenium murakami-hatanakae, a fern species belonging to Aspleniaceae, can also form independent gametophytes. Our investigation revealed gametophyte populations of H. murakami-hatanakae on three islands in the Izu Islands. Based on chloroplast DNA analysis of the gametophyte and sporophyte populations, the gametophytes were found to be maintained by vegetative reproduction without a new supply of spores from sporophytes. A comparison of the surrounding vegetation at the collection sites showed that environmental factors such as light and humidity may influence the maintenance of gametophyte populations. These results clearly show that H. murakami-hatanakae is one of the ferns capable of forming independent gametophytes. This is the first report of independent gametophytes from the suborder Aspleniineae (eupolypod II). The discovery of the independent gametophyte within a phylogenetic lineage previously thought not to form independent gametophytes will provide important insights into the morphological and functional evolution of gametophytes in ferns.
Improving the stochastic model for code pseudorange observations from Android smartphones
Authors: Bahadur Berkay , Schön Steffen 
Published: June 2024

AbstractIn recent years, there has been increasing attention to positioning, navigation, and timing applications with smartphones. Because of frequently disrupted carrier phase observations, code observations remain critical for smartphone-based positioning. Considering a realistic stochastic model is mandatory to obtain the utmost positioning performance, this study proposes a sound stochastic approach for code observations from Android smartphones. The proposed approach includes a modified version of the SIGMA-ɛ variance model with different coefficients for each GNSS constellation and a robust Kalman filter method. First the noise characteristics of observations from the Xiaomi Mi 8 smartphone are analyzed utilizing code-minus-phase combinations to estimate the coefficients for each GNSS constellation. This includes the determination of a variance model as well as a check of the probability distribution. Finally, the proposed approach is validated in the positioning domain using single-frequency code observation-based real-time standalone positioning. The results show that more than 95% of observations follow the normal distribution when the proposed approach is applied. Compared with the conventional stochastic approach, including a C/N0-dependent model and standard Kalman filter, it improves the positioning accuracy by 45.8% in a static experiment, while its improvement is equal to 26.6% in a kinematic experiment. For the static and kinematic experiments, in 50% of the epochs, the 3D positioning errors are smaller than 3.0 m and 3.4 m for the proposed stochastic approach. The results exhibit that the stochastic properties of code observations from smartphones can be successfully represented by the proposed approach.
Psychotherapeutische Interventionen im Rahmen der stationären Behandlung in Epilepsiezentren
Authors: Gleich Tobias , Hohmann Louisa , Füratsch Nora , Braun Katharina , Michaelis Rosa 
Published: June 2024

Zusammenfassung
Hintergrund
Epilepsie geht häufig mit hohen psychosozialen Belastungen einher; die Prävalenz komorbider psychischer Störungen ist entsprechend deutlich erhöht. Dissoziative Anfälle stellen zudem die wichtigste psychiatrische Differenzialdiagnose der Epilepsie dar. Die aktualisierte Epilepsieleitlinie empfiehlt die systematische diagnostische Einschätzung und Mitbehandlung von psychischen Beschwerden bei Menschen mit Anfällen.

Zielsetzung
In diesem Beitrag werden psychotherapeutische Interventionen im stationären epileptologischen Setting dargestellt.

Material und Methode
Wir beschreiben neben der praktischen Umsetzung die Finanzierungsmöglichkeiten psychotherapeutischer Interventionen beispielhaft anhand der Abläufe und Inhalte im Epilepsie-Zentrum Berlin-Brandenburg, Berlin und der Ruhr-Epileptologie Bochum.

Ergebnisse
Die Betroffenen erhalten ein auf ihre individuellen Bedürfnisse abgestimmtes, konzeptuell schulenübergreifendes Psychotherapieangebot. Abhängig von Erkrankungsphase und -dynamik sind unterschiedliche Themen, z. B. Krankheitsakzeptanz, psychosomatische Zusammenhänge, Ressourcenaktivierung o. Ä., bedeutsam. An der Schnittstelle zur poststationären Weiterbehandlung sind Motivationsförderung, Abbau von Vorbehalten bei Weiterbehandelnden und Vernetzung mit etwaigen weiterbehandelnden Einrichtungen wichtig.

Diskussion
Die Integration psychotherapeutischer Interventionen gewährleistet eine leitliniengemäße epileptologische Behandlung. Diese beinhaltet explizit auch die Versorgung von Menschen mit dissoziativen Anfällen. Das psychotherapeutische Angebot kann je nach Ressourcen der Kliniken unterschiedlich gestaltet werden. Die Organisation geht mit Chancen und Herausforderungen einher; ein intra- und interprofessioneller Austausch und Begleitevaluationen dienen der Optimierung und Qualitätssicherung.
Migratory pathways and winter destinations of Northern Gannets breeding at Helgoland (North Sea): known patterns and increasing importance of the Baltic Sea
Authors: Garthe Stefan , Peschko Verena , Fifield David A. , Borkenhagen Kai , Nyegaard Timme , Dierschke Jochen 
Published: June 2024

AbstractWe analysed the migratory behaviour of adult Northern Gannets (Morus bassanus) breeding at Helgoland in the North Sea, based on data obtained from geolocation devices in the non-breeding season 2016–2017. Birds moved east and south-west to a broad range of wintering sites, ranging from the western Baltic Sea to North-West Africa. Three out of 12 birds spent the winter in Africa, while 9 birds wintered in Europe, with the primary wintering sites in the North Sea. All but one tagged bird spent some time in the Baltic Sea or in the transitional waters between the North Sea and Baltic Sea. We also analysed data from online databases (dofbasen.dk, ornitho.de) and the German Seabirds at Sea database to explore the extent to which Northern Gannets used the western Baltic Sea, as well as the Kattegat and Skagerrak, during the winter months. Records of Northern Gannets in Danish waters have increased substantially over the last 18 winters, with particular increases in the Baltic Sea. There was also a notable increase in sightings of Northern Gannets in German Baltic Sea waters, but this occurred later than in the more northerly Danish waters. Both analyses demonstrated that Northern Gannets explored the western part of the Baltic Sea, as well as the Kattegat and Skagerrak, increasingly intensively. This recent increase in sightings is in accord with the establishment and exponential increase in the nearest breeding colony of Northern Gannets at Helgoland.
Sleep and Oxidative Stress: Current Perspectives on the Role of NRF2
Authors: Davinelli Sergio , Medoro Alessandro , Savino Rosa , Scapagnini Giovanni 
Published: June 2024

AbstractSleep is a fundamental conserved physiological state across evolution, suggesting vital biological functions that are yet to be fully clarified. However, our understanding of the neural and molecular basis of sleep regulation has increased rapidly in recent years. Among various processes implicated in controlling sleep homeostasis, a bidirectional relationship between sleep and oxidative stress has recently emerged. One proposed function of sleep may be the mitigation of oxidative stress in both brain and peripheral tissues, contributing to the clearance of reactive species that accumulate during wakefulness. Conversely, reactive species, such as reactive oxygen species (ROS) and reactive nitrogen species (RNS), at physiological levels, may act as signaling agents to regulate redox-sensitive transcriptional factors, enzymes, and other effectors involved in the regulation of sleep. As a primary sensor of intracellular oxidation, the transcription factor NRF2 is emerging as an indispensable component to maintain cellular redox homeostasis during sleep. Indeed, a number of studies have revealed an association between NRF2 dysfunction and the most common sleep conditions, including sleep loss, obstructive sleep apnea, and circadian sleep disturbances. This review examines the evidence of the intricate link between oxidative stress and NRF2 function in the context of sleep, and highlights the potential of NRF2 modulators to alleviate sleep disturbances.
Graphical Abstract
A bidirectional relationship between sleep and oxidative stress has been shown, indicating that sleep may play a protective role against the accumulation of reactive species during wakefulness and sleep deprivation. However, reactive species might also serve as signaling molecules that influence sleep regulation mechanisms. Notably, as a sensor of cellular redox changes, the transcription factor NRF2 is emerging as a key regulator of sleep homeostasis.
Intraocular pressure control efficacy and safety of HA-Mg glaucoma drainage plate implantation in the anterior chamber of rabbit eyes
Authors: Cai Mingming , Luo Wangdu , Feng Kevin , Chen Yi , Yi Lin , Zhu Xiaomin , He Ju , Liu Hong , Hutnik Cindy , Wang Yong , Li Xiangji , Xie Lin 
Published: June 2024

Abstract
The current clinical application of glaucoma drainage devices is made of non-degradable materials. These non-degradable drainage devices often trigger inflammatory responses and scar proliferation, possibly leading to surgical failure. We developed a biodegradable material hydroxyapatite-coated magnesium (HA-Mg) as a glaucoma drainage device. Twelve New Zealand white rabbits were randomly assigned to three groups: HA-Mg drainage plate group (6 right eyes), trabeculectomy group (6 right eyes), and control group (12 left eyes). Results showed that all HA-Mg drainage plates were completely degraded ~4 months postoperatively. At the 5th month postoperatively, there was no statistical difference in the corneal endothelium density between the HA-Mg drainage plate group and the control group (p = 0.857). The intraocular pressure (IOP) level in the HA-Mg drainage plate implantation group was lower than in the other two groups. The trypan blue dye still drained from the anterior chamber to the subconjunctiva 5 months after HA-Mg drainage plate implantation. HE staining revealed the scleral linear aqueous humor drainage channel and anterior synechia were observed after drainage plate completely degraded, with no obvious infiltration with the inflammatory cells. This study showed the safety and efficacy of HA-Mg glaucoma drainage plate in controlling IOP after implantation into the anterior chamber of rabbit eyes.

Graphical abstract
Antimicrobial and Anticancer Activity of Gallic Acid–Cu(II) Hybrid Nanoflowers and Gallic Acid–Zn(II) Hybrid Nanoflowers
Authors: Somtürk Yilmaz Burcu 
Published: June 2024

AbstractHerein, synthesis and characterization of hybrid nanoflowers (hNFs) using gallic acid as organic components, and Cu(II), and Zn(II) ions which were involved as the inorganic component was carried out. In the first part of the study, the morphologies of the synthesized hNFs were investigated using SEM, EDX, XRD, FT-IR, and mapping. In the second part of the study, the antimicrobial activities of the synthesized hNFs were examined. Antimicrobial activities of hNFs were systematically studied against Staphylococcus aureus, Escherichia coli, P. aeruginosa, and Candida albicans with broth microdilution and short time-kill assay. In addition, the anticancer activity of hNFs was examined. For this, A549 and MCF7 cell lines were used.
Graphical Abstract
Effect of using a ZnO-TiO2/water hybrid nanofluid on heat transfer performance and pressure drop in a flat tube with louvered finned heat exchanger
Authors: Elibol Emre Askin , Gonulacar Yunus Emre , Aktas Fatih , Tigli Burak 
Published: June 2024

AbstractThis study used an experimental setup consisting of a flat tube with a louvered finned crossflow configuration to examine the effects of utilizing a ZnO-TiO2-water hybrid nanofluid on heat transfer rate, heat transfer coefficient, Nusselt number, and pressure drop. The studies were carried out under laminar flow conditions (200 < Re < 800), at four different temperatures (50, 60, 70, 80 °C), four different volume concentrations of nanoparticles (0.025, 0.05, 0.1, 0.2%), and three different volume flow rates (4, 6, 8 LPM). The findings were compared with pure water (0%). The results indicate that using hybrid nanofluid improves the heat transfer performance and increases pressure loss in comparison with pure water. When comparing hybrid nanofluid to pure water, the largest increases in heat transfer rate, heat transfer coefficient, Nusselt number, and pressure drop were 87.8%, 21.7%, 26.4%, and 10%, respectively. In addition, it was found that, up to a specific value (0.05%), increasing the nanoparticle volume concentration enhanced the heat transfer rate, heat transfer coefficient and Nusselt number, but which began to decrease on increasing the concentration past this value. Therefore, it was concluded that nanoparticle volume concentrations greater than 0.05% negatively affect heat transfer under the current operating conditions. The maximum heat transfer rate, heat transfer coefficient, and Nusselt number were obtained under the conditions of an 8 LPM volume flow rate, 80 °C inlet temperature, and 0.05% volume concentration.
Finding eigenvectors with a quantum variational algorithm
Authors: Garcia-Escartin Juan Carlos 
Published: June 2024

AbstractThis paper presents a hybrid variational quantum algorithm that finds a random eigenvector of a unitary matrix with a known quantum circuit. The algorithm is based on the SWAP test on trial states generated by a parametrized quantum circuit. The eigenvector is described by a compact set of classical parameters that can be used to reproduce the found approximation to the eigenstate on demand. This variational eigenvector finder can be adapted to solve the generalized eigenvalue problem, to find the eigenvectors of normal matrices and to perform quantum principal component analysis on unknown input mixed states. These algorithms can all be run with low-depth quantum circuits, suitable for an efficient implementation on noisy intermediate-scale quantum computers and, with some restrictions, on linear optical systems. In full-scale quantum computers, where there might be optimization problems due to barren plateaus in larger systems, the proposed algorithms can be used as a primitive to boost known quantum algorithms. Limitations and potential applications are discussed.
Longitudinal detection of gait alterations associated with hypertension-induced cerebral microhemorrhages in mice: predictive role of stride length and stride time asymmetry and increased gait entropy
Authors: Ungvari Zoltan , Muranyi Mihaly , Gulej Rafal , Negri Sharon , Nyul-Toth Adam , Csik Boglarka , Patai Roland , Conley Shannon , Milan Madison , Bagwell Jonathan , O’Connor Daniel , Tarantini Amber , Yabluchanskiy Andriy , Toth Peter , Csiszar Anna , Ungvari Anna , Mukli Peter , Tarantini Stefano 
Published: June 2024

AbstractCerebral microhemorrhages (CMHs) are of paramount importance as they not only signify underlying vascular pathology but also have profound implications for cognitive function and neurological health, serving as a critical indicator for the early detection and management of vascular cognitive impairment (VCI). This study aimed to investigate the effects of hypertension-induced CMHs on gait dynamics in a mouse model, focusing on the utility of advanced gait metrics as sensitive indicators of subclinical neurological alterations associated with CMHs. To induce CMHs, we employed a hypertensive mouse model, using a combination of Angiotensin II and L-NAME to elevate blood pressure, further supplemented with phenylephrine to mimic transient blood pressure fluctuations. Gait dynamics were analyzed using the CatWalk system, with emphasis on symmetry indices for Stride Length (SL), Stride Time (ST), and paw print area, as well as measures of gait entropy and regularity. The study spanned a 30-day experimental period, capturing day-to-day variations in gait parameters to assess the impact of CMHs. Temporary surges in gait asymmetry, detected as deviations from median gait metrics, suggested the occurrence of subclinical neurological signs associated with approximately 50% of all histologically verified CMHs. Our findings also demonstrated that increases in gait entropy correlated with periods of increased gait asymmetry, providing insights into the complexity of gait dynamics in response to CMHs. Significant correlations were found between SL and ST symmetry indices and between these indices and the paw print area symmetry index post-hypertension induction, indicating the interdependence of spatial and temporal aspects of gait affected by CMHs. Collectively, advanced gait metrics revealed sensitive, dynamic alterations in gait regulation associated with CMHs, resembling the temporal characteristics of transient ischemic attacks (TIAs). This underscores their potential as non-invasive indicators of subclinical neurological impacts. This study supports the use of detailed gait analysis as a valuable tool for detecting subtle neurological changes, with implications for the early diagnosis and monitoring of cerebral small vessel disease (CSVD) in clinical settings.