bluuebunny/crossref_metadata_2025_split huggingface dataset:
Multi-method distribution modelling of an invasive crayfish (Pontastacus leptodactylus) at Eurasian scale
Authors: Hodson J. , South J. , Cancellario T. , Guareschi S. 
Published: July 2024

AbstractGlobally, human activities profoundly influence biodiversity, frequently favouring biological invasions. Crayfish, prominent invaders on multiple continents, pose significant varied threats. Using species distribution models (SDMs), this study explores the current and future potential distribution of Pontastacus leptodactylus, a widely introduced but under-studied crayfish, at Eurasian scale. Climate is crucial for most species’ distributions and historically SDMs focused primarily on these variables, while overlooking other environmental factors influencing species occurrence. This research employed 2 approaches: one climatic and one broader environmental model encompassing soil pH and elevation data. Both methods revealed high suitability for the species, particularly currently in Central-Europe. Future climate scenarios for 2050 do not seem to favour the species in terms of intermediate-high suitability regions, with contractions also in the native regions with both approaches. However, remarkable discrepancies were observed in some North-European regions; with the climatic approach predicting high suitability where the environmental approach did not. This study identifies P. leptodactylus as a widespread successful species outside its native range with potential for expansion under current conditions. The synthesised continental overview and projected distribution maps aid in prioritising monitoring and prevention efforts while underlining the importance for using environmental as well as climatic variables in SDMs.
Direct determination of the 237Np/238U ratio in nuclear fuel samples by multicollection inductively coupled plasma mass spectrometry (MC-ICP-MS)
Authors: Mialle S. , Nonell A. , Cruchet C. , Caussignac C. , Marie M. , Rincel A. , Isnard H. 
Published: July 2024

AbstractA new method for the direct measurement of 237Np/238U ratio in irradiated UO2 pellets by multicollection inductively coupled plasma mass spectrometry (MC-ICP-MS) is proposed. It allows the determination of ratios down to 10 × 10–6 mol·mol−1 using ion counter and Faraday cup. This approach was validated by intercomparison with the usual two-step-method (Quadrupole ICP-MS for 237Np determination and isotope dilution mass spectrometry (IDMS) for 238U). For ratios between 10 × 10–6 and 100 × 10–6 mol·mol−1, expanded uncertainties (k = 2) varied from 2.75% to 0.81%, twice lower than the uncertainties determined by the usual method.
Cardiovascular Considerations in Patients Undergoing Hematopoietic Cell Transplantation
Authors: Hundal Jasmin , Curley Thomas , Hamilton Betty K. 
Published: July 2024

Opinion StatementCardiac dysfunction is a serious adverse effect of cancer therapies that can interfere with quality of life and impact long-term survival in patients with cancer. Hematopoietic cell transplantation is a potentially curative therapy for many advanced hematologic malignancies and bone marrow failure syndromes, however is associated with several short- and long-term adverse effects, including importantly, cardiovascular toxicities. The goal of this review article is to describe the cardiovascular events that may develop before, during, and after hematopoietic cell transplantation, review risk factors for short- and long-term cardiovascular toxicities, discuss approaches to cardiovascular risk stratification and evaluation, and highlight the research gaps in the consideration of cardiovascular disease in patients undergoing hematopoietic cell transplantation. Further understanding of cardiovascular events and the factors associated with cardiovascular disease will hopefully lead to novel interventions in managing and mitigating the significant long-term burden of late cardiovascular effects in transplant survivors.
Microwave-assisted extraction of valuable phenolics from sunflower pomace with natural deep eutectic solvents and food applications of the extracts
Authors: Şen Furkan Burak , Nemli Elifsu , Bekdeşer Burcu , Çelik Saliha Esin , Lalikoglu Melisa , Aşçı Yavuz Selim , Capanoglu Esra , Bener Mustafa , Apak Reşat 
Published: July 2024

AbstractA green process, both in terms of solvent (natural deep eutectic solvents, NADES) and extraction method (microwave-assisted extraction, MAE) for the recovery of bioactive components from sunflower pomace (SFP, a by-product of oil extraction process), was designed to contribute to their sustainable valorization. For the extraction of valuable phenolics from sunflower pomace, nine potential NADES were prepared. Among them, choline chloride-urea-water (CC-U-W) at a molar ratio of 1:2:4 was selected for extraction, showing better yield and physicochemical properties. Operational parameters (extraction temperature, time, water ratio, and solvent-to-solid ratio) for MAE were optimized and modeled utilizing response surface methodology. Under optimal conditions, the antioxidant properties of SFP extract were evaluated by CUPRAC, ABTS, and DPPH methods. The total phenolic contents of extracts were evaluated by the Folin–Ciocalteu method. Phenolics were characterized by using the HPLC–PDA system. The results showed that SFP NADES extract had potential antioxidant activity which was higher than that of traditional solvents. In order to better evaluate SFP extract as a valuable food ingredient, SFP extracts at a ratio of 5, 10, and 20% added smoothie-like beverages with strawberries and yogurt were prepared. Fortification of beverages with NADES extract enhanced antioxidant efficiency, increasing total antioxidant capacity in a range of 12.4 to 68.6% and free radical scavenging capacity between 0.4 to 67.9% during both the initial and the in vitro gastrointestinal digestion stages. The addition of SFP NADES extract to food samples made a positive contribution in terms of the antioxidant activity of the final product. The results of this study revealed that sunflower by-products can be evaluated as a potential antioxidant source which is easily accessible, and the proposed extraction process has an important potential to recover bioactive compounds with high efficiency.
Effect of bariatric surgery on nutritional and metabolic parameters: does the type of antidepressant medication matter?
Authors: Schwenger Katherine J. P. , Ghorbani Yasaman , Alkass Fadi , Patel Tulasi , Jackson Timothy D. , Okrainec Allan , Allard Johane P. 
Published: July 2024

Abstract
Purpose
Depression is prevalent in patients undergoing bariatric surgery (BSx). Long-term use of antidepressant is associated with weight gain, particularly the use of selective serotonin reuptake inhibitors (SSRIs). Little is known about whether different types of antidepressants affect the response to BSx. The purpose of this study was to determine the relationship between SSRI use and nutritional and biochemical measurements in those with obesity pre-/post-BSx.

Methods
This is a cross-sectional and prospective cohort study. Patients were enrolled pre-BSx and divided into 3 groups: SSRI, non-SSRI and no antidepressant. Nutritional, biochemical and pharmacological data were collected pre- and 6 months post-BSx.

Results
Pre-BSx, 77 patients were enrolled: 89.6% female, median age 45 years and body mass index (BMI) of 45.3 kg/m2. 14.3% were taking SSRIs and had a significantly higher BMI (52.1 kg/m2) compared to 62.3% in no antidepressant (46.0 kg/m2) and 23.4% in non-SSRI antidepressants (43.1 kg/m2). At 6 months post-BSx (n = 58), the SSRI group still had significantly higher BMI in comparison to the other two groups. No other significant differences found between groups.

Conclusion
Despite higher BMI, patients taking SSRI and undergoing BSx had similar responses, based on nutritional and biochemical parameters, to those on non-SSRI or no antidepressants.

Level of evidence
Level III: Evidence obtained from well-designed cohort or case–control analytic studies.
Adsorption-desorption of lead by polycarboxylate-coated bentonite
Authors: Yu Chuang , Zeng Zhi-lei , Cai Xiaoqing , Chen Zhi-hao , Liao Rao-ping 
Published: July 2024

Abstract
To develop more economical and efficient heavy metal adsorbents, natural bentonite was employed as a raw material, and triethoxyvinylsilane served as a grafting agent to achieve the grafting bonding of sodium polyacrylate and bentonite. Structural alterations in the modified bentonite were analyzed through thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The adsorption and desorption characteristics of SAPAS-Bentonite and raw bentonite were compared and tested under various conditions, including time, temperature, pH, and lead ion concentration. The adsorption and desorption properties of sodium polyacrylate-grafted bentonite (SAPAS-Bentonite) were compared under various conditions (time, temperature, pH, and lead ion concentration). The results revealed that the modified method successfully achieved nano-scale coating of bentonite particles with sodium polyacrylate, leading to an increase in the maximum adsorption capacity of lead ions by 47.5%, reaching 165.73 mg g. A greater adsorption affinity for lead ions was exhibited by the outer sodium polycarboxylate portion of SAPAS-Bentonite compared with the inner bentonite. The adsorption of internal bentonite was limited by blocking when the adsorption of sodium polyacrylate did not reach the upper limit. The adsorption isotherm shifted from the Langmuir monolayer characteristic of the original bentonite to the S-shaped isotherm, reflecting the sodium polycarboxylate properties of SAPAS-Bentonite. Both bentonites demonstrated strong retention capacity for lead, with SAPAS-Bentonite surpassing raw bentonite in performance. This study provides valuable insights into the potential of SAPAS-Bentonite in the treatment of heavy metal pollution.
Stability of Gaomiaozi bentonite: Interlayer hydration structure and aggregation morphology
Authors: Tan Zhaomin , Fu Chengyun , Henderson Mark Julian , Dai Xuezhi , Cheng Jianfeng , Xie Jingli , Zhu Shan , Yan Minhao 
Published: July 2024

Abstract
The sustainability of high-level radioactive waste repositories situated in fractured crystalline rocks depends on the stability of bentonite liners, and this can pose a problem in certain groundwater conditions that favor the formation of colloids from backfill materials that are prone to erosion. The influence of different environments on the structure of Gaomiaozi bentonite (GMZ) and GMZ colloids (GMZC) is presented here. Different hydrated interlayer structures of bulk and colloidal forms of this bentonite from small-angle X-ray scattering (SAXS) data are demonstrated. Analysis of the scattering data showed that GMZ had three interlayer water structures: dehydrated (0W), monohydrated (1W), and bi-hydrated (2W). The colloids readily agglomerated at acidic pH (pH <5) but showed resistance to agglomeration in an alkaline condition (pH >7). The effect of Na+, K+, Mg2+, and Ca2+ on the lamellar structure and agglomerate morphology of GMZC particles was investigated. In general, the tendency of colloids to agglomerate was greater in the presence of divalent metal cations compared with monovalent metal cations. High concentrations (10–5 to 10–3 mol L–1) of divalent ions imparted order into the stacked lamellar structure after the saturation of the interlayer. In contrast, monovalent ions reduced the tendency of the particles to aggregate, leading to an abundance of colloidal nanoparticles prone to erosion. This work helps to better understand the structural characteristics of GMZC in the groundwater environment, and provides a valuable reference for the evaluation of nuclide migration in the deep geological disposal of high-level radioactive wastes.
Chimpanzee utterances refute purported missing links for novel vocalizations and syllabic speech
Authors: Ekström Axel G. , Gannon Charlotte , Edlund Jens , Moran Steven , Lameira Adriano R. 
Published: July 2024

AbstractNonhuman great apes have been claimed to be unable to learn human words due to a lack of the necessary neural circuitry. We recovered original footage of two enculturated chimpanzees uttering the word “mama” and subjected recordings to phonetic analysis. Our analyses demonstrate that chimpanzees are capable of syllabic production, achieving consonant-to-vowel phonetic contrasts via the simultaneous recruitment and coupling of voice, jaw and lips. In an online experiment, human listeners naive to the recordings’ origins reliably perceived chimpanzee utterances as syllabic utterances, primarily as “ma-ma”, among foil syllables. Our findings demonstrate that in the absence of direct data-driven examination, great ape vocal production capacities have been underestimated. Chimpanzees possess the neural building blocks necessary for speech.
Different efficacy of tyrosine kinase inhibitors by KIT and PGFRA mutations identified in circulating tumor DNA for the treatment of refractory gastrointestinal stromal tumors
Authors: Hashimoto Tadayoshi , Nakamura Yoshiaki , Komatsu Yoshito , Yuki Satoshi , Takahashi Naoki , Okano Naohiro , Hirano Hidekazu , Ohtsubo Koushiro , Ohta Takashi , Oki Eiji , Nishina Tomohiro , Yasui Hisateru , Kawakami Hisato , Esaki Taito , Machida Nozomu , Doi Ayako , Boku Shogen , Kudo Toshihiro , Yamamoto Yoshiyuki , Kanazawa Akiyoshi , Denda Tadamichi , Goto Masahiro , Iida Naoko , Ozaki Hiroshi , Shibuki Taro , Imai Mitsuho , Fujisawa Takao , Bando Hideaki , Naito Yoichi , Yoshino Takayuki 
Published: July 2024

Abstract
Background
While advanced gastrointestinal stromal tumors (GISTs) are primarily treated with tyrosine kinase inhibitors (TKIs), acquired resistance from specific mutations in KIT or PDGFRA frequently occurs. We aimed to assess the utility of circulating tumor DNA (ctDNA) as a modality of therapeutic decision-making in advanced GIST.

Methods
We conducted a pooled analysis of SCRUM-Japan studies for advanced GIST patients. We compared patient characteristics analyzed with tissue and blood samples, assessed gene alteration profiles, and evaluated prognostic implications from ctDNA status.

Results
In 133 patients, tissue and blood samples were analyzed for 89 and 44 patients, respectively. ctDNA was detected in 72.7% of cases; no prior treatment or progressive disease was significantly associated with ctDNA-positivity. ctDNA-positive patients had significantly shorter progression-free survival compared with ctDNA-negative patients (hazard ratio = 3.92; P = 0.007). ctDNA genotyping revealed a complex landscape of gene alterations, characterized by multi-exonic mutations in KIT, compared with tissue-based analysis. Patients who received TKIs matched to the identified KIT mutation in ctDNA demonstrated significantly longer PFS than those with unmatched treatment (median, 8.23 vs. 2.43 months; P < 0.001).

Conclusions
ctDNA-based analysis facilitates assessment of disease status and genomic profiles, thus potentially assisting in identifying optimal therapeutic strategies for advanced GIST patients.
Synthesis of Bifluorenylidene- and Cycloocta[1,2,3-jk:6,5,4-j′k′]difluorene-Extended Tetrathiafulvalenes: Novel Multi-Redox Systems
Authors: Nielsen Mogens Brøndsted , Hansen Jonathan Kirschner Solberg 
Published: July 2024

AbstractHerein, we present the synthesis of a novel 9,9′-bifluorenylidene-extended tetrathiafulvalene (TTF) as an E/Z isomeric mixture that was found to readily undergo an oxidative dimerization to furnish a TTF vinylogue with the two dithiafulvene units connected to an eight-membered ring fused to a bifluorenylidene core. This compound exhibited multiredox behavior and was found to take six charge states under cyclic voltammetry conditions: –2, –1, 0, +1, +2, +3. The dication corresponds to a cycloocta[1,2,3-jk:6,5,4-j′k′]difluorene with two appended 1,3-dithiolium rings.
Reductive Electrophilic Cross-Coupling for Constructing C(sp3)–C(sp3) Bonds
Authors: Qiu Youai , Li Pengfei 
Published: July 2024

AbstractThe C(sp3)–C(sp3) bond is one of the most prevalent motifs in organic compounds and holds significant importance in organic synthesis. The utilization of two alkyl electrophiles for cross-coupling stands as a vital strategy in building C(sp3)–C(sp3) bonds. Nowadays, synthetic electrochemistry is undergoing rapid development owing to its exceptional attributes not only in terms of green and economic properties by reducing the large amount of traditional chemical reductants, but also by its capacity to generate highly reactive radical intermediates under mild conditions, thereby opening up new reaction pathways and presenting novel opportunities to constructing C(sp3)–C(sp3) bonds. This article aims to comprehensively delineate the historical development of traditional electrophilic reagents in constructing C(sp3)–C(sp3) bonds, while also delving into the advantages of electrochemical electrophilic cross-coupling in this domain.1	Introduction2	Case Studies of Nickel-Catalyzed and Photochemical Alkyl Halide Cross-Coupling3	Case Studies of Electrocatalyzed Approaches for the Construction of C(sp3)–C(sp3) Bonds Using Electrophilic Reagents4	Nickel-Electrocatalyzed C(sp3)–C(sp3) Cross-Coupling of Unactivated Alkyl Halides5	Conclusion
Construction of diabatic potential energy surfaces for the SiH2+ system and dynamics studies of the Si+(2P1/2, 3/2) + H2 reaction
Authors: Li Wentao , Liang Yongping , Niu Xianghong , He Di , Xing Wei , Zhang Yong 
Published: July 2024

The construction of diabatic potential energy surfaces (PESs) for the SiH2+ system, related to the ground (12A′) and excited states (22A′), has been successfully achieved. This was accomplished by utilizing high-level ab initio energy points, employing a neural network fitting method in conjunction with a specifically designed function. The newly constructed diabatic PESs are carefully examined for dynamics calculations of the Si+(2P1/2, 3/2) + H2 reaction. Through time-dependent quantum wave packet calculations, the reaction probabilities, integral cross sections (ICSs), and differential cross sections (DCSs) of the Si+(2P1/2, 3/2) + H2 reaction were reported. The dynamics results indicate that the total ICS is in excellent agreement with experimental data within the collision energy range studied. The results also indicate that the SiH+ ion is hardly formed via the Si+(2P3/2) + H2 reaction. The results from the DCSs suggest that the “complex-forming” reaction mechanism predominates in the low collision energy region. Conversely, the forward abstraction reaction mechanism is dominant in the high collision energy region.
Faith: A Very Short Introduction
Authors: Trigg Roger 
Published: July 2024

Abstract
What is faith? It usually means religious belief, and sometimes diverse religions are grouped together as faiths, with reference to ‘faith leaders’ or ‘faith schools’. What we have faith in matters, and that involves our reason, and claims to truth to that affect everyone. Faith is not just a personal attribute, like taste, but should be open to public examination and debate. Science in the modern age appears to many to provide a more certain basis for life together, particularly in the face of the competing beliefs of different religions. Science needs as much rational justification is any religion. This book argues that all faith needs reason. It puts contemporary discussions into historical perspective, particularly in the context of Christianity. Faith also involves a commitment to action. It matters for all social life. Because religion is typically directed at what is seen as of crucial importance for human life, faith should not be marginalized or privatized. It will permeate every idea of how people should behave, and has a role in the public sphere, however respectful it should be to competing views within democracy. It could have relevance for law, and Islam in particular, tends to emphasize obedience to divine law, instead of faith. A belief that does not result in appropriate action is empty. Acting without belief is unguided. All faith needs both.
Faith and law
Authors: Trigg Roger 
Published: July 2024

Abstract
Faith is not just private, because religious beliefs are manifested in public, and come within the ambit of public law. Freedom of religion is a basic right but can clash with other human rights. How special is religious faith? The United States Constitution certainly picked it out as of particular importance. What privileges can be claimed for religious faith, and even conscience in general? In a pluralist and democratic society, alternative views, and the freedom to live by them, must be fostered. Law should not coerce religious believers into doing what they believe is morally wrong. There are major problems about how far religious and civil law can coincide. This is a particular problem for Islam and sharia law. Different approaches to law show contrasts between Muslim and Christian views of faith.
Faith and society
Authors: Trigg Roger 
Published: July 2024

Abstract
In a secular society, there is often the assumption that faith is the antithesis of reason and can make no useful contribution to public debate. It is feared that faith encourages certainty, dogmatism, and intolerance. Differences in religious belief and moral priorities must be confronted. Discounting them fails to take any religion seriously. Any faith can still be confident in its own judgement, while respecting difference. It has to come to terms itself with doubt, while invoking a wholehearted commitment that affects the whole of life. We cannot be committed to what we recognize as false, but all faith involves the will, the imagination, and emotions, as well as the intellect. Any belief that does not result in appropriate action is empty. Acting without belief is unguided. All faith needs both.
Quantifying the Use of Space in the Clock Drawing Test: Validity in Hemispatial Neglect
Authors: Diana Lorenzo , Rusconi Maria Luisa , Aiello Edoardo Nicolò , Bolognini Nadia , Monti Alessia , Corbo Massimo , Sozzi Matteo 
Published: July 2024

Abstract

Objective
The Clock Drawing Test (CDT) is a widely used test for cognitive screening as its execution taps into a large number of cognitive functions. Because of the involvement of visuospatial abilities, the CDT is also commonly used to assess hemispatial neglect. In the present study, we introduce a new quantitative scoring method for the CDT that aims to measure the use of space for each half of the clock face and asymmetries of space use.

Method
Two measures are introduced: the explored space (ES) and used space (US) for each half of the clock, as well as two derived asymmetry indices. Such new measures were applied to CDTs of four groups of participants: right brain-damaged patients without visuospatial neglect, two groups of right brain-damaged patients with varying degrees of visuospatial neglect, and a group of neurologically healthy participants.

Results
Analyses showed that only neglect patients explored and used the left clock half significantly less than the right one. This result was also confirmed by the asymmetry indices, where neglect patients showed a stronger rightward bias. For neglect patients, the US asymmetry index correlated with the patients’ scores on the neuropsychological tests. The analyses of receiver operating characteristic curves showed that left US and left ES scores had good accuracy in categorizing neglect patients.

Conclusions
The present work provides new quantitative indices of CDT space usage in hemispatial neglect. Cutoffs are provided for clinical practice.