bluuebunny/crossref_metadata_2025_split huggingface dataset:
Strategy Implementation Traceability of Breeding Shrimp Business in Indonesia
Authors: Soedrijanto Angky , Huseini Martani , Setiawan Margono , Suprayitno Eddy 
Published: February 2013

Broodstock in the preparation of the document traceability from sea to table is upstream of all the problems in the shrimp business in Indonesia. Until now there has been no regulation or standard of Good Breeding Practices Operaional procedures that are technically capable of guaranteeing the treatment of antibiotics free. The research aims to identify, locate and establish a starting point in the implementation of traceability Indonesian shrimp from hatchery business. Analyzing the performance of the business associated with breeding success in the implementation of traceability as well as find the implementation strategy of Indonesia's shrimp traceability. The results showed that tracer code to recording the capture area of the broodstock and technically seeding practices is importance. Application numeric code that registered would be included in the memorandum of sale of seed should be done jointly by the Government and the Association of hatchery. Standards and sanctions, can be implemented by the supplier, and cold storage. Supplier has the right to buy at the local market price for non-tracer prawn; so that cold storage have to refuse shrimp if nothing to seed sales without a memorandum of traceability. Based on these simple sales memorandum format, traceability could have been implemented for accurate searching. The reflects code of location tracer hatchery / backyard in District / City + catcher + spawner + breeder + seed brokers whole or in part. Technicians and Managers responsible for the source of information if cases of food safety incidents, For accounting purposes of the company, that buyers have a recording data search to find a farmer or even seed traders. In the event that a broodstock shrimp business comes from imports, the tracer code catcher broodstock and breeder may contain information search origin imported interpreted code or code numbers importers import documents.
Anticoagulation therapy in haemophilia
Authors: Tuinenburg A. , Fischer K. , Mauser-Bunschoten E. P. , Schutgens R.E.G. 
Published: February 2013

SummaryPatients with haemophilia (PWH) are relatively protected from cardiovascular death. Recent insights have shown that this is not due to less formation of atherosclerosis than in non-haemophilic men, therefore protection from the final occlusive thrombus will be the major determinant. Prevalence and incidence rates of cardiovascular disease (especially non-fatal events) are scarce, although ongoing studies are addressing this issue.Meanwhile, because the haemophilia population is aging, we are increasingly confronted with cardiovascular events. The main cardio vascular risk factors that should be part of regular screening programs are hypertension, overweight, lipometabolic disorders and smoking. Anticoagulation therapy in haemophilia is feasible, provided that individual tailored coagulation therapy and close monitoring is provided.Here, we present our view on anticoagulation management in PWH. There is an absolute need for risk assessment tools and prospective validation of suggested anticoagulation management strategies in PWH. Until then, we are managing the unknown.
Homeostatic and Circadian Contribution to EEG and Molecular State Variables of Sleep Regulation
Authors: Curie Thomas , Mongrain Valérie , Dorsaz Stéphane , Mang Géraldine M. , Emmenegger Yann , Franken Paul 
Published: February 2013

AbstractStudy Objectives:Besides their well-established role in circadian rhythms, our findings that the forebrain expression of the clock-genes Per2 and Dbp increases and decreases, respectively, in relation to time spent awake suggest they also play a role in the homeostatic aspect of sleep regulation. Here, we determined whether time of day modulates the effects of elevated sleep pressure on clock-gene expression. Time of day effects were assessed also for recognized electrophysiological (EEG delta power) and molecular (Homer1a) markers of sleep homeostasis.Design:EEG and qPCR data were obtained for baseline and recovery from 6-h sleep deprivation starting at ZT0, -6, -12, or -18.Setting:Mouse sleep laboratory.Participants:Male mice.Interventions:Sleep deprivation.Results:The sleep-deprivation induced changes in Per2 and Dbp expression importantly varied with time of day, such that Per2 could even decrease during sleep deprivations occurring at the decreasing phase in baseline. Dbp showed similar, albeit opposite dynamics. These unexpected results could be reliably predicted assuming that these transcripts behave according to a driven damped harmonic oscillator. As expected, the sleep-wake distribution accounted for a large degree of the changes in EEG delta power and Homer1a. Nevertheless, the sleep deprivation-induced increase in delta power varied also with time of day with higher than expected levels when recovery sleep started at dark onset.Conclusions:Per2 and delta power are widely used as exclusive state variables of the circadian and homeostatic process, respectively. Our findings demonstrate a considerable cross-talk between these two processes. As Per2 in the brain responds to both sleep loss and time of day, this molecule is well positioned to keep track of and to anticipate homeostatic sleep need.
Longitudinal Course of Depression Scores with and without Insomnia in Non-Depressed Individuals: A 6-Year Follow-Up Longitudinal Study in a Korean Cohort
Authors: Suh Sooyeon , Kim Hyun , Yang Hae-Chung , Cho Eo Rin , Lee Seung Ku , Shin Chol 
Published: February 2013

AbstractStudy Objective:This is a population-based longitudinal study that followed insomnia symptoms over a 6-year period in non-depressed individuals. The purpose of the study was to (1) investigate the longitudinal course of depression based on number of insomnia episodes; and (2) describe longitudinal associations between insomnia and depression, and insomnia and suicidal ideation.Design:Population-based longitudinal study.Setting:Community-based sample from the Korean Genome and Epidemiology Study (KoGES).Participants:1,282 non-depressed individuals (44% male, mean age 52.3 ± 7.14 years)Measurements and Results:This study prospectively assessed insomnia, depression, and suicidal ideation with 4 time points. Individuals were classified into no insomnia (NI), single episode insomnia (SEI), and persistent insomnia (PI; ≥ insomnia at 2+ time points) groups based on number of times insomnia was indicated. Mixed effects modeling indicated that depression scores increased significantly faster in the PI group compared to the NI (P &lt; 0.001) and SEI (P = 0.02) groups. Additionally, the PI group had significantly increased odds of depression as compared to NI or SEI (OR 2.44, P = 0.001) groups, with 18.7% meeting criteria for depression compared to the NI (5.3%) and SEI (11.6%) groups at end point. The PI group also had significantly increased odds of suicidal ideation as compared to NI or SEI (OR 1.86, P = 0.002) groups.Conclusions:Persistent insomnia significantly increases the rate in which depression occurs over time in non-depressed individuals, which ultimately leads to higher risk for depression. Additionally, having persistent insomnia also increased the risk of suicidal ideation.
Les liens entre jeux de hasard et d’argent, activités policières et demandes d’aide
Authors: Alain1 Marc , Dessureault Danny , Brunelle Natacha 
Published: February 2013

Cet article présente les résultats d’une démarche de suivi des effets macrosociologiques liés à l’implantation d’une toute nouvelle offre de jeux de hasard et d’argent présentée par Loto-Québec dans un contexte péri-urbain : le Salon de jeu de Trois-Rivières, un lieu de loisirs qui regroupe sous un même toit des appareils de loterie vidéo, des tables de poker et une roulette virtuelle. Plusieurs collectes de données ont servi à matérialiser ce bilan des effets, soit, d’une part, un suivi chronologique des appels logés au service de police de la ville et, d’autre part, un suivi des demandes d’aide et de référence pour problème de jeu pathologique, demandes tenues à jour par l’organisme Domrémy MCQ. L’analyse des données policières se révèle fidèle à ce que la littérature permet de penser, soit qu’il n’y a pas de lien entre l’introduction d’une nouvelle offre légalisée de jeux de hasard et d’argent et la criminalité. En revanche, l’absence de liens entre cette nouvelle offre et le nombre de demandes d’aide, quant à elle, va dans le sens contraire de ce que la littérature a établi. Nous proposons que la principale raison expliquant ces phénomènes tient dans le peu de succès qu’a connu le Salon de jeu pendant la période où nos travaux se sont déroulés.
Predicting the Sensitivity of the Reaction Time‐based Concealed Information Test
Authors: Noordraven Ernst , Verschuere Bruno 
Published: February 2013

SummaryCurrent lie detection and memory detection tests are imperfect. One possibility is that they work in some individuals but not in others. Here, we investigate whether we can statistically predict the accuracy of the Concealed Information Test (CIT). We examined the CIT's potential by (1) its sensitivity on an unrelated set of autobiographic questions and by (2) using mock crime target‐irrelevant differences. A mock crime CIT that included autobiographical questions was used to detect criminal intent. The mock crime CIT discriminated (receiver operating characteristic a = .87; d = 1.25; hit rate: 86%) between the criminal intent and the control condition. Using target‐irrelevant differences, but not the autobiographical questions, successfully screened out individuals and increased the CIT's accuracy (receiver operating characteristic a = .95; d = 1.67; hit rate: 97%). Our study provides preliminary evidence that we can predict for whom the CIT is likely to work and that this information can be used to increase detection efficiency. Copyright © 2013 John Wiley & Sons, Ltd.
Neue Entwicklungen bei asymmetrischen Phasentransferreaktionen
Authors: Shirakawa Seiji , Maruoka Keiji 
Published: February 2013

AbstractDie Phasentransferkatalyse bildet eine effiziente Grundlage zur Einführung praktischer Methoden in die organische Synthese, denn sie bietet mehrere Vorteile wie einfache Handhabung, milde Reaktionsbedingungen, die Eignung für großtechnische Synthesen und ein umweltfreundliches Reaktionssystem. Seit den wegweisenden Arbeiten zu hoch enantioselektiven Alkylierungen mit chiralen Phasentransferkatalysatoren ist dieses Forschungsgebiet im Hinblick auf eine umweltverträgliche, nachhaltige Chemie von Interesse, und in den vergangenen Jahrzehnten, vor allem in den letzten Jahren, wurden zahlreiche asymmetrische, durch chirale Oniumsalze und Kronenether katalysierte Umwandlungen für die Synthese wertvoller organischer Verbindungen entwickelt.
Strained Alkenes in Natural Product Synthesis
Authors: Wilson Matthew R. , Taylor Richard E. 
Published: February 2013

AbstractStrained molecules continue to challenge the ingenuity of chemists as their high‐energy bonds serve as fuel for the promotion of complex synthetic transformations. Developments in this area have resulted in the recent emergence of strained alkenes as intermediates in natural product synthesis. This Minireview highlights these recent advances along with current developments toward understanding the unique reactivity of strained alkenes.
Preparation and characterization of a pseudo‐template imprinted polymer with a chirality‐matching monomer for the separation of cinchona alkaloids by high‐performance liquid chromatography
Authors: Jiang Jiabing , Zhou Qi , Kang Chengcheng , Wu Suqin , Tang Youwen , Zuo Xiongjun 
Published: February 2013

AbstractA hydroquinidine‐imprinted stationary selector with chiral recognition for cinchona alkaloids was prepared by bulk polymerization with (+)‐(2R,3R)‐N,N′‐diallyl‐L‐tartardiamide as a functional monomer, and the recognition properties of the polymers for quinidine (QD) were analyzed with high‐performance liquid chromatography. By optimizing the preparation conditions and chromatographic conditions, such as the ratio of the mobile phase and flow rate, QD and quinine could be completely separated to the best resolution of 2.25. The chiral molecularly imprinted polymers (CMIPs) combined the virtues of traditional brush‐type chiral selectors with existing CMIPs. The results show a substantial synergistic effect between the chiral monomer and the chiral cavity of the resulting CMIPs in chiral recognition. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Synthesis, Cytotoxicity, and Apoptosis Induction Study of Antitumor Dinuclear Platinum(II) Complexes
Authors: Xu Gang , Gou Shaohua , Gao Chuanzhu 
Published: February 2013

AbstractFive novel dinuclear platinum(II) complexes with a new chiral ligand, 3‐(2‐amino‐cyclohexylamino)‐propionic acid (HP), were designed, prepared and spectrally characterized. The in vitro cytotoxicities of these compounds were evaluated against the HepG‐2, MCF‐7, A549, and HCT‐116 cell lines. The results indicated that all compounds showed cytotoxicity towards the HepG‐2 cell line. Particularly, complex X5, which has SO as a bridge, exhibited better cytotoxicity than carboplatin or oxaliplatin against all selected cell lines. Moreover, double dyeing flow cytometric resection indicated that the target compounds inhibited tumor cell growth by inducing apoptosis.
Calbindin‐D28k and calretinin in chicken inner retina during postnatal development and neuroplasticity by dim red light
Authors: Fosser Nicolás Sebastián , Ronco Laura , Bejarano Alejandro , Paganelli Alejandra R. , Ríos Hugo 
Published: February 2013

ABSTRACTMembers of the family of calcium binding proteins (CBPs) are involved in the buffering of calcium (Ca2+) by regulating how Ca2+ can operate within synapses or more globally in the entire cytoplasm and they are present in a particular arrangement in all types of retinal neurons. Calbindin D28k and calretinin belong to the family of CBPs and they are mainly co‐expressed with other CBPs. Calbindin D28k is expressed in doubles cones, bipolar cells and in a subpopulation of amacrine and ganglion neurons. Calretinin is present in horizontal cells as well as in a subpopulation of amacrine and ganglion neurons. Both proteins fill the soma at the inner nuclear layer and the neuronal projections at the inner plexiform layer. Moreover, calbindin D28k and calretinin have been associated with neuronal plasticity in the central nervous system. During pre and early postnatal visual development, the visual system shows high responsiveness to environmental influences. In this work we observed modifications in the pattern of stratification of calbindin immunoreactive neurons, as well as in the total amount of calbindin through the early postnatal development. In order to test whether or not calbindin is involved in retinal plasticity we analyzed phosphorylated p38 MAPK expression, which showed a decrease in p‐p38 MAPK, concomitant to the observed decrease of calbindin D28k. Results showed in this study suggest that calbindin is a molecule related with neuroplasticity, and we suggest that calbindin D28k has significant roles in neuroplastic changes in the retina, when retinas are stimulated with different light conditions. © 2013 Wiley Periodicals, Inc. Develop Neurobiol 73: 530–542, 2013
A Bis(hexadentate) Biphenyl‐Based N12 Ligand and Its FeII Complexes
Authors: Heider Silvio , Petzold Holm , Teucher Georg 
Published: February 2013

AbstractThe novel biphenyl‐based ligand N,N′,N″,N″′‐tetrakis(2,2′‐bipyridin‐6‐ylmethyl)‐4,4′‐dimethyl‐1,1′‐biphenyl‐2,2′,6,6′‐tetramine (6) with 12 nitrogen donor atoms has been synthesized. Ligand 6 is able to host two metal ions in an octahedral coordination sphere. This was shown by the synthesis of the dinuclear iron(II) complex 5 ([Fe2(6)]4+). Furthermore, the corresponding mononuclear iron(II) complex 4 ([Fe(6)]2+), where one coordination site is free, was obtained. Both FeII complexes show spin‐crossover behaviour, which was shown by 1H NMR spectroscopy and Evans' measurements. A comparison of the two complexes gives evidence of a sterically induced cooperative behaviour in the dinuclear complex 5.
Synthesis of Porous, Nitrogen‐Doped Adsorption/Diffusion Carbonaceous Membranes for Efficient CO2 Separation
Authors: Zhu Xiang , Chai Songhai , Tian Chengcheng , Fulvio Pasquale F. , Han Kee Sung , Hagaman Edward W. , Veith Gabriel M. , Mahurin Shannon M. , Brown Suree , Liu Honglai , Dai Sheng 
Published: February 2013

AbstractA porous, nitrogen‐doped carbonaceous free‐standing membrane (TFMT‐550) is prepared by a facile template‐free method using letrozole as an intermediate to a triazole‐functionalized‐triazine framework, followed by carbonization. Such adsorption/diffusion membranes exhibit good separation performance of CO2 over N2 and surpassing the most recent Robeson upper bound. An exceptional ideal CO2/N2 permselectivity of 47.5 was achieved with a good CO2 permeability of 2.40 × 10−13 mol m m−2 s−1 Pa−1. The latter results arise from the presence of micropores, narrow distribution of small mesopores and from the strong dipole–quadrupole interactions between the large quadrupole moment of CO2 molecules and the polar sites associated with N groups (e.g., triazine units) within the framework.
Synthesis and characterization of porphyrin‐based D‐π‐A conjugated polymers for polymer solar cells
Authors: Jiang Pei , Shi Shaowei , Chen Song , Wang Xiaochen , Wang Haiqiao , Li Yongfang , Li Xiaoyu 
Published: February 2013

AbstractTwo novel porphyrin‐based D‐A conjugated copolymers, PFTTQP and PBDTTTQP, consisting of accepting quinoxalino[2,3‐b′]porphyrin unit and donating fluorene or benzo[1,2‐b:4,5‐b′]dithiophene unit, were synthesized, respectively via a Pd‐catalyzed Stille‐coupling method. The quinoxalino[2,3‐b′]porphyrin, an edge‐fused porphyrin monomer, was used as a building block of D‐A copolymers, rather than the simple porphyrin unit in conventional porphyrin‐based photovoltaic polymers reported in literature, to enhance the coplanarity and to extend the π‐conjugated system of polymer main chains, and consequently to facilitate the intramolecular charge transfer (ICT). The thermal stability, optical, and electrochemical properties as well as the photovoltaic characteristics of the two polymers were systematically investigated. Both the polymers showed high hole mobility, reaching 4.3 × 10−4 cm2 V−1 s−1 for PFTTQP and 2.0 × 10−4 cm2 V−1 s−1 for PBDTTTQP. Polymer solar cells (PSCs) made from PFTTQP and PBDTTTQP demonstrated power conversion efficiencies (PCEs) of 2.39% and 1.53%, both of which are among the highest PCE values in the PSCs based on porphyrin‐based conjugated polymers. © 2013 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2013
Synthesis, Crystal Structure, and Thermal Behaviors of 3‐Nitro‐1,5‐bis(4,4′‐dimethylazide)‐1,2,3‐triazolyl‐3‐azapentane (NDTAP)
Authors: Wang Yinglei , Xu Kangzhen , Zhao Fengqi , Ji Yueping , Yi Jianhua , Xu Siyu , Gao Fulei , Chen Bin 
Published: February 2013

AbstractThe energetic material, 3‐nitro‐1,5‐bis(4,4′‐dimethyl azide)‐1,2,3‐triazolyl‐3‐azapentane (NDTAP), was firstly synthesized by means of Click Chemistry using 1,5‐diazido‐3‐nitrazapentane as main material. The structure of NDTAP was confirmed by IR, 1H NMR, and 13C NMR spectroscopy; mass spectrometry, and elemental analysis. The crystal structure of NDTAP was determined by X‐ray diffraction. It belongs to monoclinic system, space group C2/c with crystal parameters a=1.7285(8) nm, b=0.6061(3) nm, c=1.6712(8) nm, β=104.846(8)°, V=1.6924(13) nm3, Z=8, μ=0.109 mm−1, F(000)=752, and Dc=1.422 g cm−3. The thermal behavior and non‐isothermal decomposition kinetics of NDTAP were studied with DSC and TG‐DTG methods. The self‐accelerating decomposition temperature and critical temperature of thermal explosion are 195.5 and 208.2 °C, respectively. NDTAP presents good thermal stability and is insensitive.
Quaternary structure effects on the hexacoordination equilibrium in rice hemoglobin rHb1: Insights from molecular dynamics simulations
Authors: Morzan Uriel N. , Capece Luciana , Marti Marcelo A. , Estrin Dario A. 
Published: February 2013

AbstractNonsymbiotic hemoglobins (nsHbs) form a widely distributed class of plant proteins, which function remains unknown. Despite the fact that class 1 plant nonsymbiotic hemoglobins are hexacoordinate (6c) heme proteins (hxHbs), their hexacoordination equilibrium constants are much lower than in hxHbs from animals or bacteria. In addition, they are characterized by having very high oxygen affinities and low oxygen dissociation rate constants. Rice hemoglobin 1 (rHb1) is a class 1 nonsymbiotic hemoglobin. It crystallizes as a fully associated homodimer with both subunits in 6c state, but showing slightly different conformations, thus leading to an asymmetric crystallographic homodimer. The residues that constitute the dimeric interface are conserved among all nsHbs, suggesting that the quaternary structure could be relevant to explain the chemical behavior and biological function of this family of proteins. In this work, we analyze the molecular basis that determine the hexacoordination equilibrium in rHb1. Our results indicate that dynamical features of the quaternary structure significantly affect the hexacoordination process. Specifically, we observe that the pentacoordinate state is stabilized in the dimer with respect to the isolated monomers. Moreover, the dimer behaves asymmetrically, in a negative cooperative scheme. The results presented in this work are fully consistent with our previous hypothesis about the key role played by the nature of the CD region in determining the coordination state of globins. Proteins 2013. © 2012 Wiley Periodicals, Inc.
A fictitious play‐based response strategy for multistage intrusion defense systems
Authors: Luo Yi , Szidarovszky Ferenc , Al‐Nashif Youssif , Hariri Salim 
Published: February 2013

ABSTRACTThe recent developments of advanced intrusion detection systems in the cyber security field provide opportunities to proactively protect the computer network systems and minimize the impacts of attackers on network operations. This paper is intended to assist the network defender find its best actions to defend against multistage attacks. The possible sequences of interactions between the attackers and the network defender are modeled as a two‐player non‐zero‐sum non‐cooperative dynamic multistage game with incomplete information. The players are assumed to be rational. They take turns in making decisions by considering previous and possible future interactions with the opponent and use Bayesian analysis after each interaction to update their knowledge about the opponents. We propose a Dynamic game tree‐based Fictitious Play (DFP) approach to describe the repeated interactive decisions of the players. Each player finds its best moves at its decision nodes of the game tree by using multi‐objective analysis. All possibilities are considered with their uncertain future interactions, which are based on learning of the opponent's decision process (including risk attitude and objectives). Instead of searching the entire game tree, appropriate future time horizons are dynamically determined for both players. In the DFP approach, the defender keeps tracking the opponent's actions, predicts the probabilities of future possible attacks, and then chooses its best moves. Thus, a new defense algorithm, called Response by DFP (RDFP), is developed. Numerical experiments show that this approach significantly reduces the damage caused by multistage attacks and it is also more efficient than other related algorithms. Copyright © 2013 John Wiley & Sons, Ltd.