bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical trial: An open‐label, randomised trial of different re‐start strategies after treatment withdrawal in HBeAg negative chronic hepatitis B
Authors: Johannessen Asgeir , Reikvam Dag Henrik , Aleman Soo , Berhe Nega , Weis Nina , Desalegn Hailemichael , Stenstad Tore , Heggelund Lars , Samuelsen Ellen , Karlsen Lars Normann , Lindahl Karin , Pettersen Frank Olav , Iversen Jonas , Kleppa Elisabeth , Bollerup Signe , Winckelmann Anni Assing , Brugger‐Synnes Pascal , Simonsen Hans Erling , Svendsen Jan , Kran Anne‐Marte Bakken , Holmberg Marte , Olsen Inge Christoffer , Rueegg Corina Silvia , Dalgard Olav 
Published: July 2024

SummaryBackgroundStopping nucleos(t)ide analogue (NA) therapy in patients with chronic hepatitis B (CHB) may trigger a beneficial immune response leading to HBsAg loss, but clinical trials on re‐start strategies are lacking.AimTo assess whether it is beneficial to undergo a prolonged flare after NA cessation.MethodsOne‐hundred‐and‐twenty‐seven patients with HBeAg negative, non‐cirrhotic CHB with at least 24 months of viral suppression on NA therapy were included. All study participants stopped antiviral therapy and were randomised to either low‐threshold (ALT > 80 U/L and HBV DNA > 2000 IU/mL) or high‐threshold (ALT > 100 U/L for >4 months, or ALT > 400 U/L for >2 months) for the re‐start of therapy. The primary endpoint was HBsAg loss within 36 months of stopping antiviral treatment. The primary analysis was based on intention‐to‐treat allocation with last observation carried forward.ResultsThere was a numerical but not statistically significant difference in HBsAg loss between the low‐threshold (3 of 64; 4.7%) and the high‐threshold (8 of 63; 12.7%) group (risk difference: 8.0%, 95% CI: −2.3 to 19.6, p = 0.123). None of the patients with end‐of‐treatment HBsAg > 1000 IU/mL achieved HBsAg loss; among those with end‐of‐treatment HBsAg < 1000 IU/mL, 8 of 15 (53.3%) achieved HBsAg loss in the high‐threshold group compared to 3 of 26 (11.5%) in the low‐threshold group.ConclusionsWe could not confirm our hypothesis that a higher threshold for restart of therapy after NA withdrawal improves the likelihood of HBsAg loss within 36 months in patients with HBeAg negative CHB. Further studies including only patients with HBsAg level <1000 IU/mL and/or larger sample size and longer follow‐up duration are recommended.
Development of a group‐based behaviour change intervention for people with severe obesity informed by the social identity approach to health
Authors: Moghadam Shokraneh , Hollands Laura , Calitri Raff , Swancutt Dawn , Lloyd Jenny , Hawkins Lily , Sheaff Rod , Dean Sarah , Perry Steve , Watkins Ross , Pinkney Jonathan , Tarrant Mark ,   the PROGROUP Team
Published: July 2024

AbstractIntroductionInterventions to support behaviour change in people living with chronic health conditions increasingly use patient groups as the mode of delivery, but these are often designed without consideration of the group processes that can shape intervention outcomes. This article outlines a new approach to designing group‐based behaviour change interventions that prioritizes recipients' shared social identity as group members in facilitating the adoption of established behaviour change techniques (BCTs). The approach is illustrated through an example drawn from research focused on people living with severe obesity.MethodsA prioritization process was undertaken in collaboration with stakeholders, including behaviour change experts, clinicians, and a former patient to develop an evidence‐based, group intervention informed by the social identity approach to health. Three phases of development are reported: (1) identification of the health problem; (2) delineation of intervention mechanisms and operationalization of BCTs for group delivery and (3) intervention manualization. The fourth phase, intervention testing and optimization, is reported elsewhere.ResultsA group‐based behaviour change intervention was developed, consisting of 12 group sessions and 3 one‐to‐one consultations. The intervention aimed to support the development of shared social identity among recipients, alongside the delivery of evidence‐based BCTs, to improve the likelihood of successful intervention and health outcomes among people living with severe obesity.ConclusionsA manualized intervention, informed by the social identity approach to health, was systematically designed with input from stakeholders. The development approach employed can inform the design of behavioural interventions in other health contexts where group‐based delivery is planned.
Tax Governance and Corporate Labor Investment Efficiency: A Quasi‐Natural Experiment From China
Authors: Yang Laifeng , Lu Junwei , Wang Qing Sophie , Lai Shaojie 
Published: July 2024

ABSTRACTResearch Question/IssueWe take advantage of China's staggered rollout of the Golden Tax Phase (GTP) III reform to examine how enhanced tax governance through digitalization affects corporate labor investment efficiency (LIE).Research Findings/InsightsApplying a staggered difference‐in‐differences approach to Chinese A‐share listed companies spanning from 2010 to 2017, our research reveals a significant improvement in LIE due to digitalized tax governance. Our path analysis demonstrates that the relationship between tax governance and LIE is mediated by enhancements in corporate governance and information quality. Notably, improved information quality exerts a more substantial influence than corporate governance. In addition to these mediated pathways, we identify a residual direct effect from digitalized tax governance to LIE.Theoretical/Academic ImplicationsThis study uncovers a causal relationship between digitalized tax governance and corporate LIE. It offers new insights into the broader effects of tax governance, specifically how businesses adjust their employment decisions when tax administration becomes more digitalized.Practitioner/Policy ImplicationsThis study highlights a positive externality of digitalized tax governance, offering valuable insights for policymakers aiming to optimize tax administration processes through information technology.
Obscure representations from a pragmatic point of view
Authors: Russell Francey 
Published: July 2024

AbstractKant's most sustained discussion of obscure representations can be found in the first book of his Anthropology from a Pragmatic Point of View. What is puzzling is that in the middle of the section devoted to the topic, Kant asserts that “because this field can only be perceived in his passive side as a play of sensations, the theory of obscure representations belongs only to physiological anthropology, and so it is properly disregarded here.” So, do obscure representations belong to pragmatic anthropology or not? Kant's official position is that they do not, yet the textual evidence—we find discussions of obscure representations in 20 years of his work on pragmatic anthropology—suggests that they do, in fact, belong here. Most of the literature on obscure representations focuses on their contribution to cognition and none has clarified what it would mean to assume a “pragmatic point of view” on obscure representations, and to study them in the context of pragmatic anthropology. My aim in this paper is to provide such clarification, focusing on Kant's discussion of our propensity to “play with” obscure representations and what he calls our “art of obscuring.”
Effects of input data accuracy, catchment threshold areas and calibration algorithms on model uncertainty reduction
Authors: Wu Lei , Xu Yonghong , Li Ruizhi 
Published: July 2024

AbstractLow resolution of input data and equifinality in model calibration can lead to inaccuracy and insufficient reflection of spatial differences, thereby increasing model errors. However, the impact of input data accuracy, catchment threshold area, and calibration algorithm on model uncertainty reduction has not yet been well understood. The sequential uncertainty fitting version 2 (SUFI‐2) that is linked with the Soil and Water Assessment Tool (SWAT) in the package called SWAT Calibration Uncertainty Programs (SWAT‐CUP) was introduced to quantify the effects of different input data resolutions on parameter sensitivity and model uncertainty in the Jinghe River watershed, and the effects of different sub‐basin delineations and other two calibration algorithms on model uncertainty were also comparatively analysed. (i) USLE_C, EPCO, ALPHA_BNK, and CN2 are the most sensitive parameters among all SWAT projects. When the change of digital elevation model (DEM) resolution is small, the sensitivity of parameters does not change obviously. When the DEM resolution changes significantly, BIOMIX, LAT_SED, USLE_K, and CH_N1 become highly sensitive parameters by replacing OV_N, SMTMP, SURLAG, and USLE_P. However, the change in land use resolution has little impact on parameter sensitivity, with only a slight change in the sensitivity ranking of specific parameters. (ii) Model uncertainty responded to changes in the resolution of DEM more than land use. Most of the runoff simulations had smaller uncertainties (P factor, R factor, percentage of bias [PBIAS]) than sediment. High resolution DEM data reduced model uncertainty, but the models with 2000 m DEM resolution also achieved small uncertainty. Small catchment threshold area leads to high uncertainty of the model, and large catchment threshold areas decrease the model uncertainty. The model has relatively good simulation effects in runoff and sediment when the catchment threshold area was 2000 km2. (iii) The SWAT model has different simulation deviations and uncertainties in different calibration algorithms, the SUFI‐2 and generalized likelihood uncertainty estimation (GLUE) algorithms show better applicability than particle swarm optimization (PSO). The NSE indicators of the three algorithms are in the following order: SUFI‐2 > GLUE > PSO for runoff, and GLUE > SUFI‐2 > PSO for sediment. This study helps us understand the cause, knowledge of which moves from the particular to the general by the comprehension of essence, power, and nature in reducing model uncertainty.
Role of cover crop roots in soil organic carbon accrual—A review
Authors: Pisarčik M. , Hakl J. , Toleikiene M. , Fuksa P. , Rasmussen J. , Hood‐Nowotny R. 
Published: July 2024

AbstractAppropriate cover crop (CC) management is an important tool for the improvement of soil carbon stock; however, the relationships between carbon accumulation and CC root traits remain unclear. A literature review was performed to identify the extent and focus of recent research and to answer questions about the role of root traits of CCs in soil C accumulation with regard to species selection, mixture composition and agronomic management. The findings based on the analysis of 69 publications show that a range of root traits such as root biomass, architecture, depth of rooting, root chemical composition, as well as quantity and quality of rhizodeposition, can contribute to soil structure formation and C accumulation. These traits are usually species specific, and it seems that appropriate species combinations in the mixtures can offer the highest potential for optimization of C stock across various environments. However, there has been twice as much recent research on roots of CC monocultures than on mixtures, with little attention paid to agronomic aspects such as plant spatial arrangement or soil tillage in relation to CC root development. Considerations of real management under field conditions could be beneficial in providing greater accuracy of estimation of the contribution of CCs in increasing the SOC stock in croplands.
Effect of intra‐build design parameters on the fracture toughness properties of Electron Beam Melted Ti6Al4V
Authors: Mojib Naghmeh Melody , Fero Kaan , Atmadja Nicole , Arola Dwayne , Chen Xu , Ramulu M. 
Published: July 2024

AbstractMetal additive manufacturing technologies provide new opportunities for manufacturing complex components. However, the limited data on fracture behavior are delaying adoption in safe‐critical applications. This paper aims to evaluate the effect of orientation and the intra‐build design parameters on EBM Ti6Al4V fracture toughness using a design of experiments. Three builds comprised of over 150 compact tension samples were printed representative of the EBM build chamber, followed by microstructural characterization, X‐ray microcomputed tomography, and fracture toughness testing per ASTM E399. The average fracture toughness was 65 MPa√m, with anisotropy as the largest source of variation due to crack growth behavior with respect to the build direction. Microstructure coarsening was observed with increase in height, resulting in an increase in fracture toughness, irrespective of sample geometry or orientation. Build orientation and sample location influenced the microstructure and fracture toughness and should be considered when adopting EBM components in load‐bearing applications.
Habitat complexity versus habitat heterogeneity: Invertebrates prefer macrophyte stands with intermediate biomass and high functional diversity
Authors: Aleixo Matheus Henrique Ferreira , Possamai Luana Caroliny , de Castro Karis Soares Pereira , Yofukuji Kátia Yasuko , Cardozo Ana Lúcia Paz , Fugi Rosemara 
Published: July 2024

Abstract

Aquatic macrophytes serve as shelter and a direct source of food for invertebrates, in addition to indirectly providing items such as algae, detritus, and microorganisms. Thus, aquatic macrophytes act as habitat structuring elements, requiring a distinction between habitat complexity (physical formations such as fractal dimensions, density and biomass) and habitat heterogeneity (diversity of these structures). Here we explore the effects of habitat complexity and habitat heterogeneity on the invertebrate community.

We collected macrophytes and invertebrates from 28 sampling sites along a 13.7‐km stretch of the Baía River in Brazil, and examined specific groups (insects, microcrustaceans, and other invertebrates). Environmental variables in the sites were also measured. We aimed to explore the effects of habitat complexity (measured by macrophyte biomass) and habitat heterogeneity (evaluated through macrophyte functional diversity) on the richness and abundance of invertebrates.

We found that overall invertebrate richness was positively influenced solely by habitat heterogeneity. For invertebrate abundance, intermediate habitat complexity had more invertebrates, while habitat heterogeneity had a positive impact. Environmental variables influenced only the abundance. For specific groups, insect richness was positively influenced by habitat heterogeneity, while insect abundance decreased with high complexity and increased with high heterogeneity. Microcrustacean abundance was positively influenced by habitat complexity. Richness and abundance of other invertebrates was positively influenced by habitat heterogeneity.

Invertebrates prefer macrophyte stands with intermediate complexity and high heterogeneity. Abundance is linked to structural complexity and heterogeneity, while species richness is more strongly associated with heterogeneity. Furthermore, the impact of these factors varies among invertebrate groups.

These findings emphasise the importance of integrating a broad range of metrics, such as macrophyte biomass and functional diversity, to gain a thorough understanding of invertebrate community dynamics in future studies. Additionally, our study demonstrates that preserving macrophyte stands with high heterogeneity significantly enhances the diversity of associated invertebrate species.
Vulnerability of Eastern Tropical Pacific chondrichthyan fish to climate change
Authors: Cerutti‐Pereyra Florencia , Drenkard Elizabeth J. , Espinoza Mario , Finucci Brittany , Galván‐Magaña Felipe , Hacohen‐Domené Ana , Hearn Alexander , Hoyos‐Padilla Mauricio E. , Ketchum James T. , Mejía‐Falla Paola A. , Moya‐Serrano Ana V. , Navia Andres F. , Pazmiño Diana A. , Ramírez‐Macías Deni , Rummer Jodie L. , Salinas‐de‐León Pelayo , Sosa‐Nishizaki Oscar , Stock Charles , Chin Andrew 
Published: July 2024

AbstractClimate change is an environmental emergency threatening species and ecosystems globally. Oceans have absorbed about 90% of anthropogenic heat and 20%–30% of the carbon emissions, resulting in ocean warming, acidification, deoxygenation, changes in ocean stratification and nutrient availability, and more severe extreme events. Given predictions of further changes, there is a critical need to understand how marine species will be affected. Here, we used an integrated risk assessment framework to evaluate the vulnerability of 132 chondrichthyans in the Eastern Tropical Pacific (ETP) to the impacts of climate change. Taking a precautionary view, we found that almost a quarter (23%) of the ETP chondrichthyan species evaluated were highly vulnerable to climate change, and much of the rest (76%) were moderately vulnerable. Most of the highly vulnerable species are batoids (77%), and a large proportion (90%) are coastal or pelagic species that use coastal habitats as nurseries. Six species of batoids were highly vulnerable in all three components of the assessment (exposure, sensitivity and adaptive capacity). This assessment indicates that coastal species, particularly those relying on inshore nursery areas are the most vulnerable to climate change. Ocean warming, in combination with acidification and potential deoxygenation, will likely have widespread effects on ETP chondrichthyan species, but coastal species may also contend with changes in freshwater inputs, salinity, and sea level rise. This climate‐related vulnerability is compounded by other anthropogenic factors, such as overfishing and habitat degradation already occurring in the region. Mitigating the impacts of climate change on ETP chondrichthyans involves a range of approaches that include addressing habitat degradation, sustainability of exploitation, and species‐specific actions may be required for species at higher risk. The assessment also highlighted the need to further understand climate change's impacts on key ETP habitats and processes and identified knowledge gaps on ETP chondrichthyan species.
Changing climatic controls on the greenhouse gas balance of thermokarst bogs during succession after permafrost thaw
Authors: Heffernan Liam , Estop‐Aragonés Cristian , Kuhn McKenzie A. , Holger‐Knorr Klaus , Olefeldt David 
Published: July 2024

AbstractPermafrost thaw in northern peatlands causes collapse of permafrost peat plateaus and thermokarst bog development, with potential impacts on atmospheric greenhouse gas exchange. Here, we measured methane and carbon dioxide fluxes over 3 years (including winters) using static chambers along two permafrost thaw transects in northwestern Canada, spanning young (~30 years since thaw), intermediate and mature thermokarst bogs (~200 years since thaw). Young bogs were wetter, warmer and had more hydrophilic vegetation than mature bogs. Methane emissions increased with wetness and soil temperature (40 cm depth) and modelled annual estimates were greatest in the young bog during the warmest year and lowest in the mature bog during the coolest year (21 and 7 g C‐CH4 m−2 year−1, respectively). The dominant control on net ecosystem exchange (NEE) in the mature bog (between +20 and −54 g C‐CO2 m−2 year−1) was soil temperature (5 cm), causing net CO2 loss due to higher ecosystem respiration (ER) in warmer years. In contrast, wetness controlled NEE in the young and intermediate bogs (between +55 and −95 g C‐CO2 m−2 year−1), where years with periodic inundation at the beginning of the growing season caused greater reduction in gross primary productivity than in ER leading to CO2 loss. Winter fluxes (November–April) represented 16% of annual ER and 38% of annual CH4 emissions. Our study found NEE of thermokarst bogs to be close to neutral and rules out large CO2 losses under current conditions. However, high CH4 emissions after thaw caused a positive net radiative forcing effect. While wet conditions favouring high CH4 emissions only persist for the initial young bog period, we showed that continued climate warming with increased ER, and thus, CO2 losses from the mature bog can cause net positive radiative forcing which would last for centuries after permafrost thaw.
Partnered Recruitment: Engaging Individuals With Lived Experience in the Recruitment of Co‐Design Participants
Authors: Whitmore Carly , Mytkolli Linxi , Mangialardi Natalie , Maghera Jasmine , Rudick Adam , Shephard Kitty , Zazzera Stephanie , Saiva Anika , McQuire Tracy , Senior Peter , Sherifali Diana , Selby Peter 
Published: July 2024

ABSTRACTBackgroundYoung adults with type 1 diabetes (T1D) face complex health challenges, including a heightened risk for distress. To counter this distress, there is a need to develop accessible, acceptable comprehensive care solutions that integrate diabetes and mental health care to enhance self‐efficacy and counter mental health challenges in this population.ObjectiveTo describe the engagement of individuals with lived experience of T1D and mental health challenges in the development of a recruitment strategy to support the co‐design of an innovative integrated care programme.ResultsSeven individuals with lived experience formed a Partner Advisory Council (PAC) to recruit young adults (18–29 years old) living with T1D, their friends or family and health researchers and professionals in co‐design interviews (n = 19) and co‐design events (n = 12). The PAC played a key role in developing a comprehensive recruitment strategy, overcoming traditional barriers and stigmas in the design of an integrated model of care.ConclusionAssuming the presence of mental health challenges in young adults living with T1D during recruitment had far‐reaching impacts on the development of a whole‐person and integrated diabetes and mental health care solution. The efficient recruitment of this sample provided invaluable insights into the nuanced challenges experienced by young adults with T1D, the individual skills developed in response to their mental health challenges and the ways that this understanding can shape future programming to support mental health, quality of life and well‐being. The ongoing involvement of the PAC as co‐researchers underscores the enduring impact of patient engagement in developing integrated care solutions.Patient or Public ContributionThe co‐design of the TECC‐T1D3 model was enriched by the invaluable contributions of individuals with lived experience. This included the engagement of a diverse PAC in the recruitment of participants in co‐design interviews and co‐design events. PAC members actively participated in research decision‐making with their insights informing a robust recruitment strategy. Beyond recruitment, PAC members continue to serve as co‐researchers, shaping ongoing research and actively contributing to the TECC‐T1D3 project. Six PAC members are co‐authors on this manuscript.