bluuebunny/crossref_metadata_2025_split huggingface dataset:
A failing right heart in an eggshell: A case report of idiopathic constrictive pericarditis
Authors: Balaji Nivedha , Dodoo Sheriff N. , Adams Alex , Dixit Priyadarshini , Acosta Giancarlo , Burkle Jaime 
Published: August 2024

key Clinical MessageConstrictive Pericarditis is a rare fibrotic conversion of the pericardium that results in non‐specific clinical symptoms such as hepatomegaly, ascites, pleural effusions, and lower extremity edema. A multi‐modal diagnostic approach with cardiac imaging tools, cardiac hemodynamic measurements, and tissue biopsy can be used to diagnose Constrictive Pericarditis.AbstractConstrictive Pericarditis is a rare complication resulting in the fibrotic conversion of the pericardium secondary to idiopathic, infective, post‐surgical, or post‐radiation etiologies. The rigid and restrictive nature of the pericardium can result in non‐specific symptoms of volume overload that can mimic liver cirrhosis or congestive heart failure. We present the case of a 73‐year‐old female with constrictive pericarditis who presented with vague symptoms of abdominal pain, abdominal bloating, and bilateral lower extremity edema. This case report highlights the clinical manifestation, invasive, and non‐invasive diagnostic work‐up, and management of constrictive pericarditis.
Obesity as a misleading factor in the diagnosis of type 1 diabetes mellitus: A case report
Authors: Dróżdż Olgierd , Bińczyk Wiktoria , Siudek Bartosz , Błaszczyszyn Katarzyna , Grajnert Filip Jan , Grzelka Michalina Zofia , Rabczyński Maciej 
Published: August 2024

Key Clinical MessageA comprehensive evaluation, including symptoms, medical history, C‐peptide levels, and anti‐GAD antibodies, is essential for distinguishing between diabetes' types, particularly in cases of diagnostic uncertainty. While obesity is often associated with T2DM, BMI should be viewed as a factor rather than a criterion for the exclusion of diabetes type.
The Wheel of Fortune: Helical Wheel Alanine Scanning of a Spider Venom Antimicrobial Peptide Reveals Residues Involved in Antimicrobial and Cytotoxic Activity
Authors: Fernando Jomari C. , Batucan Jeremiah D. , Peran Jacquelyn E. , Salvador‐Reyes Lilibeth A. , Villaraza Aaron Joseph L. 
Published: August 2024

AbstractA preference for several amino acids is observed to occur at particular positions of cationic α‐helical antimicrobial peptides (AMPs), which ensures the formation of amphipathic regions once they assume their correct secondary structure in membranes or membrane‐mimicking environments and makes them active against pathogens. This study determined the effect of alanine mutations on the secondary structure and bioactivity of lyp1987 (GRLQAFLAKMKEIAAQTL‐NH2), a cationic α‐helical AMP obtained from the venom of Lycosa poonaensis which exhibits broad range activity against Gram‐positive and Gram‐negative bacteria with micromolar minimum inhibitory concentrations (MIC). CD spectroscopy revealed no significant difference in the secondary structure, with all alanine‐substituted analogs exhibiting predominantly α‐helical structure in buffered 2,2,2‐trifluoroethanol solution. Alanine substitution at Glu12 and Thr17 increased the activity of lyp1987 against Gram‐positive and ‐negative bacteria, while alanine substitution at Lys9 increased its selectivity against Gram‐positive bacteria. Further investigation can be done to determine positions and substitutions that will give less cytotoxic analogs.
Adsorption of Colloidal Nanoparticles to Supports: Employing Electrostatic Charge Screening and Barrierless Self‐Assembly as Nanointegration Strategy
Authors: Tack Meike , Plech Anton , Reichenberger Sven 
Published: August 2024

AbstractSurfactant‐free nanoparticles can be adsorbed on a support material by electrostatic deposition which requires electrostatic attraction between the nanoparticles and the support material. However, when nanoparticles and support have a similar isoelectric point (IEP), it is difficult to create such electrostatically attractive conditions and trigger the adsorption process by pH adjustment. In this work, we present an alternative approach to support laser‐generated metal nanoparticles by controlled precipitation onto thin graphene oxide (GO) nanosheets via a kinetically barrierless process induced by high ionic strength. This enables supporting the nanoparticles on the GO sheets with a uniform distribution even though they share a similar IEP. The broad applicability of this method is demonstrated by using different metals, nanoparticle diameters, and mass loadings. In summary, this approach allows supporting nanoparticles regardless of their surface charge.
Dysregulation of parvalbumin expression and neurotransmitter imbalance in the auditory cortex of the BTBR mouse model of autism spectrum disorder
Authors: Tang Binliang , Zhao Jingting , Zhang Cui , Qi Pengwei , Zheng Shuyu , Xu Chengyuan , Chen Ming , Ye Xiangming 
Published: August 2024

AbstractIndividuals diagnosed with autism spectrum disorder (ASD) frequently exhibit abnormalities in auditory perception, a phenomenon potentially attributed to alterations in the excitatory and inhibitory cells constituting cortical circuits. However, the exact genetic factors and cell types affected by ASD remain unclear. The present study investigated the balance of excitatory and inhibitory activity in the auditory cortex using BTBR T+ Itpr3tf/J (BTBR) mice, a well‐established model for autism research. Our investigation unveiled a reduction in parvalbumin‐positive (PV+) neurons within the AC of BTBR mice. Remarkably, in vivo magnetic resonance spectroscopy studies disclosed an elevation in glutamate (Glu) levels alongside a decrement in γ‐aminobutyric acid (GABA) levels in this cortical region. Additionally, transcriptomic analysis of the mouse model facilitated the classification of several ASD‐associated genes based on their cellular function and pathways. By comparing autism risk genes with RNA transcriptome sequencing data from the ASD mouse model, we identified the recurrent target gene Scn1a and performed validation. Intriguingly, we uncovered the specific expression of Scn1a in cortical inhibitory neurons. These findings hold significant value for understanding the underlying neural mechanisms of abnormal sensory perception in animal models of ASD.
Genesis and reservoir preservation mechanism of 10 000‐m ultradeep dolomite in Chinese craton basin
Authors: Zhu Guangyou , Li Xi , Zhao Bin , Jiang Hua , Cao Yinghui , Zhang Yan , Chen Weiyan , Li Tingting , Hou Jiakai 
Published: August 2024

AbstractThe 10 000‐m ultradeep dolomite reservoir holds significant potential as a successor field for future oil and gas exploration in China's marine craton basin. However, major challenges such as the genesis of dolomite, the formation time of high‐quality reservoirs, and the preservation mechanism of reservoirs have always limited exploration decision‐making. This research systematically elaborates on the genesis and reservoir‐forming mechanisms of Sinian–Cambrian dolomite, discussing the ancient marine environment where microorganisms and dolomite develop, which controls the formation of large‐scale Precambrian–Cambrian dolomite. The periodic changes in Mg isotopes and sedimentary cycles show that the thick‐layered dolomite is the result of different dolomitization processes superimposed on a spatiotemporal scale. Lattice defects and dolomite embryos can promote dolomitization. By simulating the dissolution of typical calcite and dolomite crystal faces in different solution systems and calculating their molecular weights, the essence of heterogeneous dissolution and pore formation on typical calcite and dolomite crystal faces was revealed, and the mechanism of dolomitization was also demonstrated. The properties of calcite and dolomite (104)/(110) grain boundaries and their dissolution mechanism in carbonate solution were revealed, showing the limiting factors of the dolomitization process and the preservation mechanism of deep buried dolomite reservoirs. The in situ laser U‐Pb isotope dating technique has demonstrated the timing of dolomitization and pore formation in ancient carbonate rocks. This research also proposed that dolomitization occurred during the quasi‐contemporaneous or shallow‐burial periods within 50 Ma after deposition and pores formed during the quasi‐contemporaneous to the early diagenetic periods. And it was clear that the quasi‐contemporaneous dolomitization was the key period for reservoir formation. The systematic characterization of the spatial distribution of the deepest dolomite reservoirs in multiple sets of the Sinian and the Cambrian in the Chinese craton basins provides an important basis for the distribution prediction of large‐scale dolomite reservoirs. It clarifies the targets for oil and gas exploration at depths over 10 000 m. The research on dolomite in this study will greatly promote China's ultradeep oil and gas exploration and lead the Chinese petroleum industry into a new era of 10 000‐m deep oil exploration.
Metal Acetylene Dicarboxlylates as Catalyst for Printable Low Temperature Carbon Precursors
Authors: Otto Thomas , Gellrich Christin , Bräuniger Yannik , Mielewczyk Lukas , Getzschmann Jürgen , Seewald Felix , Klauss Hans‐Henning , Grothe Julia , Kaskel Stefan 
Published: August 2024

AbstractThe synthesis of various metal acetylene dicarboxylates (MxADC, M=Cu, Ag, Fe, Co, Ni) via new methods are reported. The previously unknown crystal structures for Ag2ADC and FeADC are presented. The behaviour of the different metal dicarboxylates and their role as graphitization catalysts in a printable highly energetic carbon precursor is investigated in detail. Despite the copper compound has the lowest decomposition temperature of all studied acetylene dicarboxylates and is significantly enhancing the conductivity of carbon thin films obtained at low pyrolysis temperatures, the catalytic effect of cobalt and iron on graphitizing carbon results in a superior conductivity in carbon thin films pyrolyzed at lower temperatures down to 600 °C. The newly designed precursors are demonstrated to produce micro‐supercapacitors via 3D‐piezoelectric inkjet technique at low pyrolysis temperature.
A Metal‐Free Photochemical Atom Transfer Radical Addition of CBr4 onto Alkenes as a Key Step for Their Conversion to Propargylamines
Authors: Kontara Iliana I. , Panagiotari Vasiliki A. , Mountanea Olga G. , Mantzourani Christiana , Gkizis Petros L. , Kokotos George 
Published: August 2024

AbstractΑ green and sustainable metal‐free photochemical protocol for the atom transfer radical addition (ATRA) of carbon tetrabromide onto alkenes was developed. Phenylglyoxylic acid was employed as the photoinitiator to promote the water‐mediated anti‐Markovnikov photochemical addition. A vast variety of alkenes was employed successfully, providing the corresponding products in good to high yields with excellent regioselectivity. The photochemical protocol found an application towards the three‐step synthesis of secondary or tertiary propargylamines starting from alkenes.
Impacts of early psychological changes on correlates of weight‐loss maintenance: Seeking increased precision for sustained behavioural obesity treatment effects
Authors: Annesi James J. , Powell Sara M. , Stewart Francine A. 
Published: August 2024

AbstractIssue AddressedObesity is an increasing worldwide health issue. In affluent English‐speaking countries, obesity ranges from ~28% (Australia) to ~42% (United States) of the adult population. Enabling weight loss beyond an initial 6 months is an unresolved challenge.MethodsWomen with obesity participated in community‐based obesity treatments incorporating either cognitive‐behavioural methods emphasizing self‐regulatory skills development (n = 106) or typical information/education processes (n = 47). Psychosocial, behavioural, and weight changes were measured.ResultsSignificant overall improvements in exercise‐related self‐regulation and self‐efficacy, mood, physical activity/exercise (PA/exercise), diet, and weight were found from baseline–month 6 (weight‐loss phase) and baseline–month 12, but not from months 6–12 (weight‐loss maintenance phase). Significantly greater improvements were found in the cognitive‐behavioural group. Within the weight‐loss phase, changes in both PA/exercise and diet significantly contributed to the explained variance in weight loss, whereas within the weight‐loss maintenance phase, only change in PA/exercise was a significant predictor. There was no significant relationship of weight loss across phases. Months 6–12 change in PA/exercise significantly mediated relationships of changes in self‐regulation→weight, mood→weight, and self‐efficacy→weight. Earlier scores and score changes in mood and self‐efficacy significantly impacted the subsequent parallel relationships.ConclusionsCognitive‐behavioural methods affect psychosocial changes leading to initial changes in diet, PA/exercise, and weight. Those changes then impact subsequent changes in PA/exercise—a primary malleable correlate of maintained weight loss.So What?This research extended previous findings to better‐inform behavioural obesity‐treatment foci to address the pervasive public health problem of attaining and sustaining weight loss. Findings related to PA/exercise will help impact health‐promotion outcomes.
Comparative analysis of prescription patterns and errors in government versus private hospitals in Dhaka: A cross‐sectional study
Authors: Samad Md Abdus , Sikdar K. M. Yasif Kayes , Munia Ashfia Tasnim , Patwary Farhan Tanvir , Sarkar Md Raihan , Rashed Md. Rashidul Islam 
Published: August 2024

AbstractBackground and ObjectivesPrescription errors can inadvertently compromise the effectiveness and increase the risk of adverse events. This study aims to compare prescription patterns and errors between government and private hospitals in Dhaka, Bangladesh, by evaluating the World Health Organization (WHO) prescription indicators, polypharmacy, and omission errors.MethodsBetween September 2021 and November 2021, a total of 399 prescriptions were collected from outpatient departments of various government and private hospitals from patients or their attendants. The data were analyzed using the statistical package STATA 15. Chi‐square and Fisher's exact test were employed to determine associations (p < 0.05) among various types of categorical data.ResultsOf the collected prescriptions, 48% (n = 192) were from government, while 52% (n = 207) were from private hospitals. The mean number of medicines per prescription was 5.16 for government and 5.87 for private hospitals. Generic names were absent (0%) in both types of hospitals. Antibiotics were present in 34.37% of prescriptions from government and 51.69% from private hospitals. Moreover, injection were found in 17.70% of government and 18.35% of private hospitals' prescriptions. Government hospitals adhered to 67.97% of the essential drug list, whereas private hospitals adhered to 80.42%. Associations between hospital types were observed in missing age, and comorbidities, while no association was found in inscription mistakes. Missing dates and signatures were also associated with hospital types. Polypharmacy was observed in 49.47% of government hospitals and 71.01% of private hospitals. Additionally, polypharmacy in females, pediatrics, geriatrics, and missing comorbidity were also associated with hospital types (p < 0.05).ConclusionBoth government and private hospitals exhibited similar deviations from the WHO prescribing indicators. While government hospitals showed more omission errors, private hospitals exhibited higher rates of polypharmacy. Physicians in both types of hospitals should be vigilant about omission errors, maintain the WHO prescribing indicators, and minimize polypharmacy.
The mediating role of self‐esteem in the relationship between hope and life satisfaction among university students during a global health crisis
Authors: Chan Stephen Cheong Yu , Huang Qi Lu 
Published: August 2024

AbstractBackground and AimsThe worldwide health emergency sparked by the COVID‐19 pandemic has deeply shaken educational environments, posing unprecedented challenges to university students’ well‐being. While individual links between self‐esteem, hope, and well‐being are established, their combined impacts during crises remain underexplored. Our study addresses this gap by investigating the interplay among hope, self‐esteem, and life satisfaction within the context of university students navigating the challenges posed by the pandemic.MethodsConducting an online cross‐sectional self‐administered survey during Hong Kong's third pandemic wave, we measured hope, self‐esteem, and life satisfaction using validated scales. Three hundred and fifteen university students (211 females; mean age = 22.08;SD = 2.74) participated.ResultsThrough multiple regression and mediation analyses, our findings indicate that university students with elevated hope and self‐esteem scored higher on life satisfaction measures. Specifically, our analysis revealed that self‐esteem may serve as a partial mediator in the relationship between hope and life satisfaction, highlighting how heightened hope indirectly enhances life satisfaction by strengthening self‐esteem.ConclusionThis study reveals intricate relationships among hope, self‐esteem, and life satisfaction in university students, particularly during external adversities like the COVID‐19 pandemic. The implications extend to mental health interventions, emphasizing the potential benefits of cultivating hope and self‐esteem to enhance life satisfaction among university students confronting formidable challenges.
Structure designing, interface engineering, and application prospects for sodium‐ion inorganic solid electrolytes
Authors: Wu Meng , Liu Hong , Qi Xiang , Li Dabing , Wang Chao , Nan Ce‐Wen , Fan Li‐Zhen 
Published: August 2024

AbstractAll‐solid Na‐ion batteries (ASNIBs) present significant potential for integration into large‐scale energy storage systems, capitalizing on their abundant raw materials, exemplary safety, and high energy density. Among the pivotal components propelling the advancement of ASNIBs, inorganic solid electrolytes (ISEs) have garnered substantial attention in recent years due to their high ionic conductivity (σ), wide electrochemical stability window (ESW), and high shear modulus. Herein, this review systematically encapsulates the latest strides in Na‐ion ISEs, furnishing a comprehensive panorama of various ISE systems along with their interface engineering strategies against the electrodes. The prime focus resides in accentuating key strategies for refining ion conduction properties and interfacial compatibility of ISEs through structure design and interface modification. Furthermore, the review explores the foremost challenges and prospects inherent to sodium‐ion ISEs, striving to deepen our understanding of how to engineer more robust and efficient ISEs and interface stability, poised for the forthcoming era of advanced ASNIBs.
Estrogen treatment in combination with pyruvate kinase M2 inhibition precipitate significant cumulative antitumor effects in colorectal cancer
Authors: Zamer Batoul Abi , Cui Zheng‐Guo , Eladl Mohamed Ahmed , Hamad Mawieh , Muhammad Jibran Sualeh 
Published: August 2024

AbstractIt is well established that pyruvate kinase M2 (PKM2) activity contributes to metabolic reprogramming in various cancers, including colorectal cancer (CRC). Estrogen or 17β‐estradiol (E2) signaling is also known to modulate glycolysis markers in cancer cells. However, whether the inhibition of PKM2 combined with E2 treatment could adversely affect glucose metabolism in CRC cells remains to be investigated. First, we confirmed the metabolic plasticity of CRC cells under varying environmental conditions. Next, we identified glycolysis markers that were upregulated in CRC patients and assessed in vitro mRNA levels following E2 treatment. We found that PKM2 expression, which is highly upregulated in CRC clinical samples, is not altered by E2 treatment in CRC cells. In this study, glucose uptake, generation of reactive oxygen species (ROS), lactate production, cell viability, and apoptosis were evaluated in CRC cells following E2 treatment, PKM2 silencing, or a combination of both. Compared to individual treatments, combination therapy resulted in a significant reduction in cell viability and enhanced apoptosis. Glucose uptake and ROS production were markedly reduced in PKM2‐silenced E2‐treated cells. The data presented here suggest that E2 signaling combined with PKM2 inhibition cumulatively targets glucose metabolism in a manner that negatively impacts CRC cell growth. These findings hold promise for novel therapeutic strategies targeting altered metabolic pathways in CRC.
Targeting the hydrophobic region of pyroglutamate‐modified amyloid‐β by tyrocidine A prevents its nucleation–aggregation process and its “catalytic effect” on the Aβs aggregation
Authors: Qin Wenjing , Chen Daoyuan , Wang Youqiao , Liu Ziyi , Zhou Binhua , Bu Xianzhang , Wen Gesi 
Published: August 2024

AbstractPyroglutamate (pE)‐modified amyloid‐β (Aβ) peptides play a crucial role in the development of Alzheimer's disease. pEAβ3‐42 can rapidly form oligomers that gradually elongate hydrophobic segments to form β‐sheet‐rich amyloid intermediates, ultimately resulting in the formation of mature amyloid fibrils. pEAβ3‐42 can also catalyze the aggregation of Aβ species and subsequently accelerate the formation of amyloid senile plaques. Considering the recent clinical success of the pEAβ3‐42‐targeting antibody donanemab, molecules that strongly bind pEAβ3‐42 and prevent its aggregation and catalytic effect on Aβs may also provide potential therapeutic options for Alzheimer's disease. Here, we demonstrate that the natural antibiotic cyclopeptide tyrocidine A (TA) not only strongly inhibits the aggregation of Aβ1‐42 as previously reported, but also interacts with the hydrophobic C‐terminus and middle domain of pEAβ3‐42 to maintain an unordered conformation, effectively impeding the formation of initial oligomers and subsequently halting the aggregation of pEAβ3‐42. Furthermore, TA can disrupt the “catalytic effect” of pEAβ3‐42 on amyloid aggregates, effectively suppressing Aβ aggregation and ultimately preventing the pathological events induced by Aβs.