bluuebunny/crossref_metadata_2025_split huggingface dataset:
Phenylmethoxybis(tetrazolium) ion-association complexes with an anionic indium(III) — 4-(2-pyridylazo)resorcinol chelate
Authors: Stefanova Teodora , Gavazov Kiril 
Published: October 2012

Abstract
Complex formation and liquid-liquid extraction were studied in systems containing indium(III), 4-(2-pyridylazo)resorcinol (PAR), phenylmethoxybis(tetrazolium) salt (MBT), water and chloroform. The following MBTs, which differ only by the number of -NO2 groups in their cationic parts, were used: 3,3′-(3,3′-dimetoxy-4,4′-biphenylene)bis(2,5-diphenyl-2H-tetrazolium chloride) (Blue Tetrazolium chloride, BT), 3,3′-(3,3′-dimetoxy-4,4′-biphenylene)bis[2-(4-nitrophenyl)-5-phenyl-2H-tetrazolium chloride] (Nitro Blue Tetrazolium chloride, NBT) and 3,3′-(3,3′-dimetoxy-4,4′-biphenylene)bis[2,5-di(4-nitrophenyl)-2H-tetrazolium chloride] (Tetranitro Blue Tetrazolium chloride, TNBT). The composition of the formed ternary complexes was determined, In:PAR:MBT=1:2:2, and the optimum conditions for their extraction found: pH, shaking time, concentration of the reagents and the sequence of their addition. Some key constants were estimated: constants of extraction (Kex), constants of association (β) and constants of distribution (KD). BT appears to be the best MBT for extraction of the In(III)-PAR species, [In3+(OH)3(PAR)2]4−, (Log Kex=10.9, Log β=9.8, Log KD=1.12, R%=92.7%). Several additional characteristics concerning its application as extraction-spectrophotometric reagent were calculated: limit of detection (LOD = 0.12 µg cm−3), limit of quantification (LOD = 0.40 µg cm−3) and Sandell’s sensitivity (SS =1.58 ng cm−2); Beer’s law is obeyed for In(III) concentrations up to 3.2 µg mL−1 with a molar absorptivity coefficient of 7.3×104 L mol−1 cm−1 at λmax=515 nm.
Cardiac sarcoidosis: A review on the work-up and management
Authors: Solun Boris , Marcoviciu Dana , Belnik Yulia , Azran Tamar , Dicker Dror , Perek Yosef , Goitein Orly 
Published: October 2012

Abstract
Sarcoidosis is a multisystem granulomatous disease of unknown etiology and with variable presentation. Skin, lymph nodes, lungs, eyes and the central nervous system are mostly involved. Cardiac sarcoidosis (CS) is a rare condition with clinical manifestations in about 5% of patients. Since it increases the risk of acute cardiac failure, ventricular arrhythmia, conduction disturbances and even sudden death, it aggravates markedly the prognosis. The early diagnosis of CS is difficult, requiring the use of diagnostic tools such as electrocardiographic monitoring, two-dimensional echocardiography, radionuclide scan, cardiac magnetic resonance imaging, positron emission tomography and endomyocardial biopsy. Once the diagnosis of CS is established, there is a need for early corticosteroids treatment, with or without immunosuppressive therapy, to prevent deterioration of cardiac function. In patients with refractory ventricular tachyarrhythmia, markedly reduced left ventricular ejection fraction and high risk of sudden death, prophylactic insertion of a pacemaker or implantable defibrillator is recommended. We had the opportunity to treat a patient with CS and to review the currently accepted diagnostic and treatment approach.
Urban transport safety assessment in akure based on corresponding performance indicators
Authors: Oye Adedamola , Aderinlewo Olufikayo , Croope Silvana 
Published: October 2012

Abstract
The level of safety of the transportation system in Akure, Nigeria was assessed by identifying the associated road safety problems and developing the corresponding safety performance indicators. These indicators were analysed with respect to accidents that occurred within the city from the year 2005 to 2009 based on the corresponding attributable risk measures. The results of the analysis showed the state of existing safety programs in Akure town. Six safety performance indicators were identified namely alcohol and drug use, excessive speeds, protection system (use of seat belts and helmets), use of day time running lights, state of vehicles (passive safety) and road condition. These indicators were used to determine the percentage of injury accidents as follows: 83.33% and 86.36% for years 2005 and 2006 respectively, 81.46% for year 2007 while years 2008 and 2009 had 82.86% and 78.12% injury accidents respectively.
Physical Rehabilitation of Patients in the Intensive Care Unit Requiring Extracorporeal Membrane Oxygenation: A Small Case Series
Authors: Rahimi Rod A. , Skrzat Julie , Reddy Dereddi Raja S. , Zanni Jennifer M. , Fan Eddy , Stephens R. Scott , Needham Dale M. 
Published: October 2012

Background and Purpose
Neuromuscular weakness and impaired physical function are common and long-lasting complications experienced by intensive care unit (ICU) survivors. There is growing evidence that implementing rehabilitation therapy shortly after ICU admission improves physical function and reduces health care utilization. Recently, there is increasing interest and utilization of extracorporeal membrane oxygenation (ECMO) to support patients with severe respiratory failure. Patients receiving ECMO are at great risk for significant physical impairments and pose unique challenges for delivering rehabilitation therapy. Consequently, there is a need for innovative examples of safely and feasibly delivering active rehabilitation to these patients.

Case Description
This case report describes 3 patients with respiratory failure requiring ECMO who received physical rehabilitation to illustrate and discuss relevant feasibility and safety issues.

Outcomes
In case 1, sedation and femoral cannulation limited rehabilitation therapy while on ECMO. In the 2 subsequent cases, minimizing sedation and utilizing a single bicaval dual lumen ECMO cannula placed in the internal jugular vein allowed patients to be alert and participate in active physical therapy while on ECMO, illustrating feasible rehabilitation techniques for these patients.

Discussion
Although greater experience is needed to more fully evaluate the safety of rehabilitation on ECMO, these initial cases are encouraging. We recommend systematically and prospectively tracking safety events and patient outcomes during rehabilitation on ECMO to provide greater evidence in this area.
Late-Holocene changes in character and behaviour of land-terminating glaciers on James Ross Island, Antarctica
Authors: Carrivick Jonathan L. , Davies Bethan J. , Glasser Neil F. , Nývlt Daniel , Hambrey Michael J. 
Published: October 2012

AbstractVirtually no information is available on the response of land-terminating Antarctic Peninsula glaciers to climate change on a centennial timescale. This paper analyses the topography, geomorphology and sedimentology of prominent moraines on James Ross Island, Antarctica, to determine geometric changes and to interpret glacier behaviour. The moraines are very likely due to a late-Holocene phase of advance and featured (1) shearing and thrusting within the snout, (2) shearing and deformation of basal sediment, (3) more supraglacial debris than at present and (4) short distances of sediment transport. Retreat of ~100 m and thinning of 15–20 m has produced a loss of 0.1 km3 of ice. The pattern of surface lowering is asymmetric. These geometrical changes are suggested most simply to be due to a net negative mass balance caused by a drier climate. Comparisons of the moraines with the current glaciological surface structure of the glaciers permits speculation of a transition from a polythermal to a cold-based thermal regime. Small land-terminating glaciers in the northern Antarctic Peninsula region could be cooling despite a warming climate.
Ice-core net snow accumulation and seasonal snow chemistry at a temperate-glacier site: Mount Waddington, southwest British Columbia, Canada
Authors: Neff Peter D. , Steig Eric J. , Clark Douglas H. , McConnell Joseph R. , Pettit Erin C. , Menounos Brian 
Published: October 2012

AbstractA 141m ice core was recovered from Combatant Col (51.385° N, 125.258° W; 3000ma.s.l.), Mount Waddington, Coast Mountains, British Columbia, Canada. Records of black carbon, dust, lead and water stable isotopes demonstrate that unambiguous seasonality is preserved throughout the core, despite summer surface snowmelt and temperate ice. High accumulation rates at the site (>4 m ice eq. a-1) limit modification of annual stratigraphy by percolation of surface meltwater. The ice-core record spans the period 1973–2010. An annually averaged time series of lead concentrations from the core correlates well with historical records of lead emission from North America, and with ice-core records of lead from the Greenland ice sheet. The depth-age scale for the ice core provides sufficient constraint on the vertical strain to allow estimation of the age of the ice at bedrock. Total ice thickness at Combatant Col is ~250 m; an ice core to bedrock would likely contain ice in excess of 200 years in age. Accumulation at Combatant Col is significantly correlated with both regional precipitation and large-scale geopotential height anomalies.
Healing and expression of growth factors (TGF-β and PDGF) in canine radial ostectomy gap containing platelet-rich plasma
Authors: Souza T. F. B. , Ferrreira G. T. N. M. , Sakamoto S. S. , Albuquerque V. B. , Bonfim S. R. M. , Luvizotto M. C. R. , Louzada M. J. Q. , Andrade A. L. 
Published: October 2012

SummaryObjectives: To evaluate bone healing in an experimental radial ostectomy in dogs treated with autologous platelet-rich plasma (PRP), through histological, densitometric, radiographic studies, as well as expression of growth factors in the ostectomy gap.Methods: Twenty-one dogs were randomly divided into either a control or a PRP group. All underwent unilateral ostectomy of the radius to generate a gap of 2.0 mm, that was stabilized with external skeletal fixation. The ostectomy gap was either filled with PRP or left empty as a control. The radiographic and densitometric studies were performed after surgery, then at intervals until 60 days during the post-surgery period. Histological and immunohistochemical evaluations were performed at seven or 60 days post-surgery. Analyses were performed using a statistical analysis system, and the level of significance was set at p <0.05.Results: The median radiographic healing score in the PRP group increased significantly between day 0 and day 60. Furthermore, at 60 days, the median healing score and the proportion of healed ostectomies in the control group (score 1; 1/6 healed) and the PRP group (score 5; 4/5 healed) were significantly different. There were differences between groups in radiographic and densitometric values at days 45 and 60. The histological evaluation showed advanced bone healing at 60 days in the PRP group and signs of delayed union in the control group.Clinical relevance: Platelet-rich plasma can be used as an adjuvant therapy because it may promote better bone healing of a radial ostectomy treated with external skeletal fixation in dogs.
Dual mobility canine total hip prosthesis: Implant characteristics and surgical procedure
Authors: Autefage A. , Palierne S. , Dembour T. , Chancrin J.-L. , Guillaumot P. 
Published: October 2012

SummaryProsthetic dislocation is one of the most common complications after canine hip replacement. The use of dual mobility acetabular components has been shown to reduce the rate of dislocation in first intent hip replacement in human patients who are at high risk for dislocation. In such implants, a mobile polyethylene liner articulates on one side with a metallic acetabular component and on the other side with a metallic prosthetic head. A dual mobility cemented acetabular component has been designed for use in dogs, and is available for use in association with a previously designed modular femoral component. This report describes the characteristics and the procedure for implantation of this implant combination.
Service volontaire européen : le public, les apports du programme
Authors: Cohen Delphine 
Published: October 2012

Résumé Cet article prend appui sur l’évaluation du programme Jeunesse 2000-2006 réalisée pour la Commission européenne en 2007. Il se base sur un nombre important de données empiriques recueillies dans quatre régions auprès de différents acteurs : jeunes, organisations, correspondants régionaux, collectivités. Centré sur les bénéficiaires, il rend compte dans un premier temps des caractéristiques des jeunes volontaires et, dans un second temps, de la façon dont ils ont vécu cette expérience ainsi que de son impact, à plus long terme, sur la citoyenneté, l’employabilité et le sentiment d’appartenance à l’Union européenne.
Formes et effets de la pluridisciplinarité
Authors: Campéon Arnaud , Le Bihan-Youinou Blanche , Mallon Isabelle 
Published: October 2012

La maladie d’Alzheimer et les troubles apparentés sont depuis quelques années constitués en enjeux majeurs de santé publique. Cette reconnaissance s’est accompagnée de la mise en place d’un dispositif gradué et spécialisé via , notamment, la création de Centres mémoires de ressources et de recherche (CMRR) où peuvent être effectués le diagnostic puis le suivi des patients. Si la pluridisciplinarité constitue une caractéristique majeure des CMRR, qui regroupent une diversité de professionnels de santé (gériatres, neurologues, psychiatres, psychologues, neuropsychologues, infirmières etc.) assurant l’accompagnement des patients, l’analyse comparative de trois sites montre qu’il existe des formes variées de pluridisciplinarité, en fonction de la composition des équipes. Cet article propose d’éclairer les approches différenciées de trois types de spécialistes – les gériatres, les neurologues et dans une moindre mesure les psychiatres – qui travaillent au sein de ces CMRR, ainsi que la façon dont leurs relations façonnent leurs pratiques professionnelles.
La gestion de cas en gérontologie : nouveau métier, nouvelles questions
Authors: Corvol Aline , Moutel Grégoire , Somme Dominique 
Published: October 2012

La gestion de cas est une pratique professionnelle qui s’implante actuellement en France, en particulier dans le domaine des soins aux personnes âgées en perte d'autonomie, sous l’impulsion du Plan National Alzheimer 2008-2012. Les « gestionnaires de cas » sont des professionnels qui interviennent auprès de personnes âgées vivant à domicile dont la situation est jugée particulièrement complexe sur le plan médical et social. Ils ont une expérience professionnelle comme infirmiers, travailleur social, psychologue ou ergothérapeute, et reçoivent une formation spécifique. Ils évaluent les besoins des personnes suivies et planifient et coordonnent les soins et les aides nécessaires. Ils accompagnent la personne sur le long terme, avec des visites régulières à domicile. L’implantation de ce nouveau service s’accompagne de la mise en place d’outils visant à favoriser le travail en commun des acteurs des secteurs sanitaires et sociaux au niveau d’un territoire pour lutter contre la fragmentation du système et promouvoir l’intégration. Nous discutons ici des spécificités du modèle français de gestion de cas, dit « intensif », et des questions éthiques qu’il soulève. Elles concernent principalement trois domaines : le respect des choix des personnes vulnérables, en particulier en cas de refus de soins ; le respect de leur vie privée alors que des informations personnelles sont recueillies et partagées ; et la place possible du gestionnaire de cas dans le système d’allocation des ressources.
Croissance et dépenses de santé
Authors: Cornilleau Gérard 
Published: October 2012

Résumé Les dépenses de santé représentent une part importante du PIB et de l’emploi. Elles concourent à l’augmentation du bien-être dans une proportion difficile à mesurer mais très certainement importante. En conséquence, la hausse des dépenses peut être favorable du point de vue de la croissance si celle-ci est mesurée correctement ( i.e. en intégrant le bien-être). Toutefois, il n’est pas vraisemblable que la hausse des dépenses stimule structurellement celle du revenu monétaire. Une hausse plus rapide que celle du PIB peut être justifiée du point de vue du bienêtre mais doit être financée par une hausse des prélèvements. Dans la crise, le secteur de la santé est un stabilisateur de l’économie et il est alors normal et souhaitable de laisser se creuser le déficit « conjoncturel ». Une réforme structurelle, difficile à mettre en place concrètement, séparant les fonctions microéconomique (apporter du bienêtre à la population) et macroéconomique (réguler le revenu monétaire), serait très utile pour éviter une gestion purement budgétaire de l’assurance maladie et du secteur de la santé.
Les complémentaires et la crise : menace ou opportunité ?
Authors: Caniard Étienne , Meyer Christine 
Published: October 2012

Résumé Dans un contexte de crise, à côté d’un système obligatoire fragilisé par les moindres recettes, qu’en est-il des organismes complémentaires en santé ? Les marges diminuent, les résultats sont lissés ; quelle que soit leur forme, ils se restructurent et se développent. Les transferts des régimes de base contribuent à leur croissance, mais les organismes complémentaires bénéficient peu des timides politiques d’efficience, et ont été taxés de + 10 % en trois ans. Le taux de couverture de la population s’améliore, pourtant leur contribution à la solidarité fait débat. Entre développement et protection sociale, leur rôle est en jeu.
Formation des soignants en France : la difficile émergence de nouveaux modèles
Authors: Rothier Bautzer Éliane 
Published: October 2012

Résumé La professionnalisation des infirmiers à la fin du XIX e siècle s’opère sous l’influence des modèles anglais puis américain, qui imposent un rôle infirmier spécifique centré sur la personne malade davantage que sur sa pathologie, objet d’intérêt premier du médecin. Une élite infirmière universitaire se constitue dans les universités américaines, produisant des théories de soins centrées sur le patient alors que le terrain des soins reste centré sur les pathologies. Les infirmières françaises non universitaires, jusqu’au XXI e siècle, s’inspirent de ces modèles. On constate enfin la prégnance de ces oppositions encore aujourd’hui : le déficit d’intégration des soins centrés sur la pathologie et sur le patient nourrit la pénurie de professionnels et compromet le soin des patients, notamment chroniques.
Atypical Activation of the Unfolded Protein Response in Cystic Fibrosis Airway Cells Contributes to p38 MAPK-Mediated Innate Immune Responses
Authors: Blohmke Christoph J. , Mayer Matthew L. , Tang Anthony C. , Hirschfeld Aaron F. , Fjell Christopher D. , Sze Marc A. , Falsafi Reza , Wang Shirley , Hsu Karolynn , Chilvers Mark A. , Hogg James C. , Hancock Robert E. W. , Turvey Stuart E. 
Published: October 2012

AbstractInflammatory lung disease is the major cause of morbidity and mortality in cystic fibrosis (CF); understanding what produces dysregulated innate immune responses in CF cells will be pivotal in guiding the development of novel anti-inflammatory therapies. To elucidate the molecular mechanisms that mediate exaggerated inflammation in CF following TLR signaling, we profiled global gene expression in immortalized human CF and non-CF airway cells at baseline and after microbial stimulation. Using complementary analysis methods, we observed a signature of increased stress levels in CF cells, specifically characterized by endoplasmic reticulum (ER) stress, the unfolded protein response (UPR), and MAPK signaling. Analysis of ER stress responses revealed an atypical induction of the UPR, characterized by the lack of induction of the PERK–eIF2α pathway in three complementary model systems: immortalized CF airway cells, fresh CF blood cells, and CF lung tissue. This atypical pattern of UPR activation was associated with the hyperinflammatory phenotype in CF cells, as deliberate induction of the PERK–eIF2α pathway with salubrinal attenuated the inflammatory response to both flagellin and Pseudomonas aeruginosa. IL-6 production triggered by ER stress and microbial stimulation were both dependent on p38 MAPK activity, suggesting a molecular link between both signaling events. These data indicate that atypical UPR activation fails to resolve the ER stress in CF and sensitizes the innate immune system to respond more vigorously to microbial challenge. Strategies to restore ER homeostasis and normalize the UPR activation profile may represent a novel therapeutic approach to minimize lung-damaging inflammation in CF.
Broad Cross-Presentation of the Hematopoietically Derived PR1 Antigen on Solid Tumors Leads to Susceptibility to PR1-Targeted Immunotherapy
Authors: Alatrash Gheath , Mittendorf Elizabeth A. , Sergeeva Anna , Sukhumalchandra Pariya , Qiao Na , Zhang Mao , St. John Lisa S. , Ruisaard Kathryn , Haugen Christine E. , Al-Atrache Zein , Jakher Haroon , Philips Anne V. , Ding Xiaoling , Chen Jie Qing , Wu Yun , Patenia Rebecca S. , Bernatchez Chantale , Vence Luis M. , Radvanyi Laszlo G. , Hwu Patrick , Clise-Dwyer Karen , Ma Qing , Lu Sijie , Molldrem Jeffrey J. 
Published: October 2012

Abstract
PR1 is a HLA-A2–restricted peptide that has been targeted successfully in myeloid leukemia with immunotherapy. PR1 is derived from the neutrophil granule proteases proteinase 3 (P3) and neutrophil elastase (NE), which are both found in the tumor microenvironment. We recently showed that P3 and NE are taken up and cross-presented by normal and leukemia-derived APCs, and that NE is taken up by breast cancer cells. We now extend our findings to show that P3 and NE are taken up and cross-presented by human solid tumors. We further show that PR1 cross-presentation renders human breast cancer and melanoma cells susceptible to killing by PR1-specific CTLs (PR1-CTL) and the anti-PR1/HLA-A2 Ab 8F4. We also show PR1-CTL in peripheral blood from patients with breast cancer and melanoma. Together, our data identify cross-presentation as a novel mechanism through which cells that lack endogenous expression of an Ag become susceptible to therapies that target cross-presented Ags and suggest PR1 as a broadly expressed tumor Ag.
ZBTB7B (Th-POK) Regulates the Development of IL-17–Producing CD1d-Restricted Mouse NKT Cells
Authors: Enders Anselm , Stankovic Sanda , Teh Charis , Uldrich Adam P. , Yabas Mehmet , Juelich Torsten , Altin John A. , Frankenreiter Sandra , Bergmann Hannes , Roots Carla M. , Kyparissoudis Konstantinos , Goodnow Chris C. , Godfrey Dale I. 
Published: October 2012

Abstract
CD1d-dependent NKT cells represent a heterogeneous family of effector T cells including CD4+CD8− and CD4−CD8− subsets that respond to glycolipid Ags with rapid and potent cytokine production. NKT cell development is regulated by a unique combination of factors, however very little is known about factors that control the development of NKT subsets. In this study, we analyze a novel mouse strain (helpless) with a mis-sense mutation in the BTB-POZ domain of ZBTB7B and demonstrate that this mutation has dramatic, intrinsic effects on development of NKT cell subsets. Although NKT cell numbers are similar in Zbtb7b mutant mice, these cells are hyperproliferative and most lack CD4 and instead express CD8. Moreover, the majority of ZBTB7B mutant NKT cells in the thymus are retinoic acid–related orphan receptor γt positive, and a high frequency produce IL-17 while very few produce IFN-γ or other cytokines, sharply contrasting the profile of normal NKT cells. Mice heterozygous for the helpless mutation also have reduced numbers of CD4+ NKT cells and increased production of IL-17 without an increase in CD8+ cells, suggesting that ZBTB7B acts at multiple stages of NKT cell development. These results reveal ZBTB7B as a critical factor genetically predetermining the balance of effector subsets within the NKT cell population.