bluuebunny/crossref_metadata_2025_split huggingface dataset:
Modified multiple papilla full flap combined with tunneling and de-epithelialized gingival graft to manage severe gingival recession in mandibular incisors: literature review and case report
Authors: Dong Ta Quan , Van Vo Nhan , Le Bui Hanh My , Quoc Tran Trung Dang , Hoang Viet 
Published: August 2024

Abstract
Gingival recession is a common condition in adults, causing esthetic issues or tooth sensitivity in patients. Gingival recession in the lower incisors area after orthodontic treatment is often difficult to predict, due to anatomical factors such as thin phenotype, shallow vestibular depth, and low frenum attachment. A young male patient presented to the clinic with severe Cairo Class I gingival recession at tooth 41 after 2 years of orthodontic treatment. Surgery combining tunneling technique and multiple papilla full thickness flap was performed to treat the patient after endodontic treatment. The clinical case was followed up to monitor gingival margin recovery one year post-surgery. The clinical case introduces a treatment method for severe localized gingival recession in the lower anterior region of a single tooth.
Reconstructive management of a patient with Tessier number 10 cleft
Authors: Sơn Trần Thiết , Nhật Phạm Kiến , Nghĩa Phan Tuấn , Dung Phạm Thị Việt , Thuý Tạ Thị Hồng , Pellerin Phillipe 
Published: August 2024

Abstract
Tessier number 10 cleft is one of the rarest facial clefts. Surgical treatment of this type of cleft is challenging due to the complexity of periorbital and temporal soft tissue deformities. A 23-year-old male patient presented with typical facial deformities of Tessier number 10 cleft. The surgical procedure involved using a free anterolateral thigh flap to reconstruct the eye socket, while the superficial temporal artery pedicle scalp flap was used to reconstruct the eyebrow deformity. The patient had no complications and 16 months after surgery, the patient had good aesthetic results. A hair-bearing scalp flap with a pedicle of the frontal branch of the superficial temporal artery combined with an anterolateral thigh-free flap can effectively resolve most soft tissue deformities of Tessier number 10 cleft and reconstruct the orbital socket in a single surgery. At the same time, it augments the soft tissue of the frontotemporal area and provides good aesthetic results.
Management of open abdomen complication after laparotomy in an ovarian cancer patient with intraperitoneal metastasis
Authors: Jeong Jae Hoon , Lee Jae Hyun , Park Chongsoo 
Published: August 2024

Abstract
This case report highlights the management of complications from an open abdomen following surgery for ovarian mucinous adenocarcinoma, a rare subtype of ovarian cancer. A 63-year-old female underwent extensive surgery, including single-port laparoscopic total bilateral salpingo-oophorectomy, right hemicolectomy, small bowel resection, cholecystectomy, and jejunostomy. Postoperatively, she experienced bile leakage, leading to significant skin and fascial damage and an abdominal skin defect. Early detection and multidisciplinary management were crucial. Treatment involved vacuum-assisted closure dressing, repeated debridement, and closure of the open abdomen with a local flap. This case emphasizes the complexities of managing ovarian mucinous adenocarcinoma and the critical role of a multidisciplinary approach in treating postoperative complications, underscoring the importance of vigilant postoperative care and timely intervention.
A rare case of sigmoid diverticulitis presenting as colocutaneous left lumbar fistula
Authors: Potkonjak Vesna , Milic Petar , Vuckovic Ljiljana , Perunovic Jelena , Potkonjak Dario 
Published: August 2024

Abstract
Colonic diverticula are very common as asymptomatic findings on endoscopic examination. Diverticulitis as a complication occurs in ~4% of these patients with well-known further complications. Colocutaneous fistulas are very rare and are usually caused by percutaneous drainage procedures of abscess formations or as a complication of the natural disease. We present here a case report of a 70-year-old man who initially presented with signs of sepsis and later developed a colocutaneous fistula in the lumbar region.
Intuitionistic S4 as a logic of topological spaces
Authors: de Groot Jim , Shillito Ian 
Published: August 2024

Abstract
We design and study various topological semantics for the diamond-free intuitionistic modal logic $\textsf{iS4}$, an intuitionistic analogue of $\textsf{S4}$. Ultimately we prove that ordinary topological spaces can be used as semantics, using the specialization order to interpret intuitionistic implication and the interior for the modality. Some of our soundness and completeness results are mechanised in Coq.
Application of the EBSD Technique in the Study of Porosity and Permeability in Deformation Bands in Sandstone
Authors: Afonso Flávia Priscila Souza , Lagoeiro Leonardo , Fossen Haakon , Barbosa Paola Ferreira , Pinto Celeste Bertassoni , de Souza Camila Gomes Peçanha 
Published: August 2024

Abstract
Deformation bands are common constituents of porous clastic fluid reservoirs. Various techniques have been used to study deformation band structure and the associated changes in porosity and permeability. However, the use of electron backscatter diffraction technique is limited. Thus, more information is needed regarding the crystallographic relationships between detrital crystals, which can significantly impact reservoir rock quality. We employ microscopic and microstructural investigation techniques to analyze the influence of cataclastic deformation bands on pore space. Porosity measurements of the Cretaceous Ilhas Group sandstone in NE Brazil, obtained through computerized microtomography, indicate that the undeformed domains exhibit a total porosity of up to 13%. In contrast, this porosity is slightly over 1% in the deformation bands. Scanning electron microscopy analyses revealed the presence of grain fragmentation and dissolution microstructures, along with cement-filling pre-existing pores. The electron backscatter diffraction analyses indicated extensive grain fragmentation and minimal contribution from intracrystalline plasticity as a deformation mechanism. However, the c axes of quartz crystals roughly align parallel to the orientation of the deformation band. In summary, we have confirmed and quantified the internal changes in a deformation band cluster, with grain size reduction and associated compaction as the main mechanism supported by quartz cementation.
Patient and Provider Opinions Regarding Chaperones for Sensitive Exams
Authors: Coffin Elisabeth M.O , Suydam Camille R , O’Hara Thomas A , Bandera Bradley , Burgess Pamela L 
Published: August 2024

ABSTRACT

Introduction
Recommendations for chaperone use during sensitive exams have been left mostly to individual institutions, despite a paucity of data providing guidance. The purpose of this study was to survey patients and medical providers on their attitudes toward chaperone use and explore factors that may influence these attitudes.

Materials and Methods
A survey was administered at a single tertiary military medical center to providers and patients across multiple specialties, and further sub-analysis of the data were completed. For patients, sub-analysis was done for gender, age, history of sexual abuse, and clinic seen. For providers, sub-analysis was done for provider gender and training status. Before data collection, this study was deemed exempt from institutional review board approval by the Eisenhower Army Medical Center Human Research and Protections Office.

Results
A total of 319 patient surveys and 61 provider surveys were collected. Fifty seven percent of patients have no preference regarding chaperone use, 19% prefer having a chaperone, and 24% prefer to not have a chaperone. Female patients and patients with a history of sexual abuse are more likely to prefer a chaperone. Forty two percent of providers always use a chaperone, 79% are more likely to use a chaperone if a patient is of the opposite gender, and 43% select a chaperone based on the gender of the patient. Male providers and providers still in training are more likely to use a chaperone.

Conclusions
The majority of patients do not have a preference regarding chaperone presence during sensitive exams; however, female gender and history of sexual abuse increase the likelihood of a patient preferring to have a chaperone present. These factors should be considered when creating an institutional policy regarding chaperone use. Future research should focus on homosexual and transgender patient preferences as this has yet to be explored.
Irregular fixation: I. Fixed points and librating orbits of the Brown Hamiltonian
Authors: Grishin Evgeni 
Published: August 2024

ABSTRACT
In hierarchical triple systems, the inner binary is slowly perturbed by a distant companion, giving rise to large-scale oscillations in eccentricity and inclination, known as von-Zeipel–Lidov–Kozai oscillations. Stable systems with a mild hierarchy, where the period ratio is not too small, require an additional corrective term, known as the Brown Hamiltonian, to adequately account for their long-term evolution. Although the Brown Hamiltonian has been used to accurately describe the highly eccentric systems on circulating orbits where the periapse completes a complete revolution, the analysis near its elliptical fixed points had been overlooked. We derive analytically the modified fixed points including the Brown Hamiltonian and analyse its librating orbits (where the periapse motion is limited in range). We compare our result to the direct three-body integrations of millions of orbits and discuss the regimes of validity. We numerically discover the regions of orbital instability, allowed and forbidden librating zones with a complex, fractal, structure. The retrograde orbits, where the mutual inclination is $\iota \ \gt\ 90\ \rm deg$, are more stable and allowed to librate for larger areas of the parameter space. We find numerical fits for the librating-circulating boundary. Finally, we discuss the astrophysical implications for systems of satellites, stars, and compact objects. In a companion paper (Paper II), we apply our formalism to the orbits of irregular satellites around giant planets.
Optical intraday variability analysis for the BL Lacertae object 1ES 1426+42.8
Authors: Chang X , Xiong D R , Yi T F , Liu C X , Bhatta G , Xu J R , Gong Y L 
Published: August 2024

ABSTRACT
The observation data of blazar 1ES 1426+42.8 were obtained using the 1.02 m optical telescope of Yunnan Observatories during 2021 to 2023. Intraday variability (IDV) is detected on seven nights. We use the turbulent model to investigate the mechanism of IDV in 1ES 1426+42.8. The fitting light curves match the actual IDV curves well. Using this model, we obtain the parameters such as the size of turbulent cells and the width of pulses in the jet. A possible short-lived quasi-periodic oscillation (QPO) of $58.55 \pm 8.09$ min was detected on 2022 April 26 whose light curve exhibits eight cycles at $\gt 3\sigma$ global significance and confirmed by several different techniques. Through a more detailed analysis of the light curve of this night, we find that the period is shortened from 54.23 min ($4\sigma$) to 29.71 min ($3\sigma$). The possible QPO and period shortening phenomenon are best explained by the processes of magnetic reconnections.
SCOTCH – search for clandestine optically thick compact H ii regions: II
Authors: Patel A L , Urquhart J S , Yang A Y , Moore T , Thompson M A , Menten K M , Csengeri T 
Published: August 2024

ABSTRACT
In this study we present 18$-$24 GHz and high-angular-resolution (0.5 arcsec) radio wavelength Australia Telescope Compact Array follow-up observations towards a sample of 39 HC H ii region candidates. These objects, taken from a sample hosting 6.7 GHz methanol masers, were chosen due to the compact and optically thick nature of their continuum emission. We have detected 27 compact radio sources and constructed their spectral energy distributions over the 5–24 GHz range to determine the young H ii region’s physical properties, i.e. diameter, electron density ${\it n}_{\mbox{e}}$, emission measure, Lyman continuum flux ${\it N}_{\mbox{Ly}}$, and turnover frequency ${\nu }_{\mbox{t}}$. The flux measurements are fitted for 20 objects assuming an ionization-bounded H ii region with uniform density model. For the remaining seven objects that lack constraints spanning both their optically thick and thin regimes, we utilize relations from the literature to determine their physical properties. Comparing these determined parameters with those of known hypercompact (HC) and ultracompact (UC) H ii regions, we have identified 13 HC H ii regions, six intermediate objects that fall between HC H ii and UC H ii regions, six UC H ii regions and one radio jet candidate which increases the known population of HC H ii regions by $\sim$50 per cent. All the young and compact H ii regions are embedded in dusty and dense clumps and $\sim$80 per cent of the HC H ii regions identified in this work are associated with various maser species (CH$_3$OH, H$_2$O, and OH). Four of our radio sources remain optically thick at 24 GHz; we consider these to be among the youngest HC H ii regions.
Central role of SUMOylation in the regulation of chromatin interactions and transcriptional outputs of the androgen receptor in prostate cancer cells
Authors: Launonen Kaisa-Mari , Varis Vera , Aaltonen Niina , Niskanen Einari A , Varjosalo Markku , Paakinaho Ville , Palvimo Jorma J 
Published: August 2024

AbstractThe androgen receptor (AR) is pivotal in prostate cancer (PCa) progression and represents a critical therapeutic target. AR-mediated gene regulation involves intricate interactions with nuclear proteins, with many mediating and undergoing post-translational modifications that present alternative therapeutic avenues. Through chromatin proteomics in PCa cells, we identified SUMO ligases together with nuclear receptor coregulators and pioneer transcription factors within the AR’s protein network. Intriguingly, this network displayed a significant association with SUMO2/3. To elucidate the influence of SUMOylation on AR chromatin interactions and subsequent gene regulation, we inhibited SUMOylation using ML-792 (SUMOi). While androgens generally facilitated the co-occupancy of SUMO2/3 and AR on chromatin, SUMOi induced divergent effects dependent on the type of AR-binding site (ARB). SUMOi augmented AR’s pioneer-like binding on inaccessible chromatin regions abundant in androgen response elements (AREs) and diminished its interaction with accessible chromatin regions sparse in AREs yet rich in pioneer transcription factor motifs. The SUMOi-impacted ARBs divergently influenced AR-regulated genes; those associated with AR-mediated activation played roles in negative regulation of cell proliferation, while those with AR-mediated repression were involved in pattern formation. In conclusion, our findings underscore the pervasive influence of SUMOylation in shaping AR’s role in PCa cells, potentially unveiling new therapeutic strategies.
Stress granule formation helps to mitigate neurodegeneration
Authors: Glineburg M Rebecca , Yildirim Evrim , Gomez Nicolas , Rodriguez Genesis , Pak Jaclyn , Li Xingli , Altheim Christopher , Waksmacki Jacob , McInerney Gerald M , Barmada Sami J , Todd Peter K 
Published: August 2024

Abstract
Cellular stress pathways that inhibit translation initiation lead to transient formation of cytoplasmic RNA/protein complexes known as stress granules. Many of the proteins found within stress granules and the dynamics of stress granule formation and dissolution are implicated in neurodegenerative disease. Whether stress granule formation is protective or harmful in neurodegenerative conditions is not known. To address this, we took advantage of the alphavirus protein nsP3, which selectively binds dimers of the central stress granule nucleator protein G3BP and markedly reduces stress granule formation without directly impacting the protein translational inhibitory pathways that trigger stress granule formation. In Drosophila and rodent neurons, reducing stress granule formation with nsP3 had modest impacts on lifespan even in the setting of serial stress pathway induction. In contrast, reducing stress granule formation in models of ataxia, amyotrophic lateral sclerosis and frontotemporal dementia largely exacerbated disease phenotypes. These data support a model whereby stress granules mitigate, rather than promote, neurodegenerative cascades.
Redundant but essential functions of PARP1 and PARP2 in DNA ligase I-independent DNA replication
Authors: Bhandari Seema Khattri , Wiest Nathaniel , Sallmyr Annahita , Du Ruofei , Tomkinson Alan E 
Published: August 2024

Abstract
While DNA ligase I (LigI) joins most Okazaki fragments, a backup pathway involving poly(ADP-ribose) synthesis, XRCC1 and DNA ligase IIIα (LigIIIα) functions along with the LigI-dependent pathway and is also capable of supporting DNA replication in the absence of LigI. Here we have addressed for the first time the roles of PARP1 and PARP2 in this pathway using isogenic null derivatives of mouse CH12F3 cells. While single and double null mutants of the parental cell line and single mutants of LIG1 null cells were viable, loss of both PARP1 and PARP2 was synthetically lethal with LigI deficiency. Thus, PARP1 and PARP2 have a redundant essential role in LigI-deficient cells. Interestingly, higher levels of PARP2 but not PARP1 associated with newly synthesized DNA in the LIG1 null cells and there was a much higher increase in PARP2 chromatin retention in LIG1 null cells incubated with the PARP inhibitor olaparib with this effect occurring independently of PARP1. Together our results suggest that PARP2 plays a major role in specific cell types that are more dependent upon the backup pathway to complete DNA replication and that PARP2 retention at unligated Okazaki fragments likely contributes to the side effects of current clinical PARP inhibitors.
PANDA-3D: protein function prediction based on AlphaFold models
Authors: Zhao Chenguang , Liu Tong , Wang Zheng 
Published: August 2024

Abstract
Previous protein function predictors primarily make predictions from amino acid sequences instead of tertiary structures because of the limited number of experimentally determined structures and the unsatisfying qualities of predicted structures. AlphaFold recently achieved promising performances when predicting protein tertiary structures, and the AlphaFold protein structure database (AlphaFold DB) is fast-expanding. Therefore, we aimed to develop a deep-learning tool that is specifically trained with AlphaFold models and predict GO terms from AlphaFold models. We developed an advanced learning architecture by combining geometric vector perceptron graph neural networks and variant transformer decoder layers for multi-label classification. PANDA-3D predicts gene ontology (GO) terms from the predicted structures of AlphaFold and the embeddings of amino acid sequences based on a large language model. Our method significantly outperformed a state-of-the-art deep-learning method that was trained with experimentally determined tertiary structures, and either outperformed or was comparable with several other language-model-based state-of-the-art methods with amino acid sequences as input. PANDA-3D is tailored to AlphaFold models, and the AlphaFold DB currently contains over 200 million predicted protein structures (as of May 1st, 2023), making PANDA-3D a useful tool that can accurately annotate the functions of a large number of proteins. PANDA-3D can be freely accessed as a web server from http://dna.cs.miami.edu/PANDA-3D/ and as a repository from https://github.com/zwang-bioinformatics/PANDA-3D.
Young Adults’ Attention to Reduced Exposure Claims in IQOS Advertising and Associations With Product Perceptions and Use Intentions.
Authors: Mercincavage Melissa , Wackowski Olivia A , Chen-Sankey Julia , Thrasher James F , Audrain-McGovern Janet , Strasser Andrew A 
Published: August 2024

Abstract

Introduction
Noncombusted tobacco products, particularly those authorized as modified-risk tobacco products, may appeal to young adults. This cross-sectional study explored young adults’ attention to reduced exposure claims in IQOS advertising and its associations with product perceptions and use intentions.

Aims and Methods
Fifty-one young adults aged 21–29 (mean age = 24.5 years old, 54.9% who smoked cigarettes, 47.1% male, 66.7% White) viewed an IQOS advertisement containing two reduced exposure claims (one large, one detailed) for 20 seconds during eye-tracking, then completed postexposure questionnaires (risk beliefs, harm perceptions, attitudes, and use intentions). We compared attention and questionnaire measures by smoking status and examined associations between attention to reduced exposure claims and questionnaire measures.

Results
Overall, the large (vs. detailed) reduced exposure claim attracted young adults’ attention more quickly, but the detailed claim held attention longer than all other advertisement features (p’s &lt; .001). There were no differences by smoking status in how quickly either claim attracted or held initial attention, but young adults who smoked (vs. did not smoke) spent more cumulative time looking at the large claim and less time looking at the detailed claim (p’s &lt; .05). Among those who smoked, greater dwell time on the detailed reduced exposure claim was associated with more beliefs about reduced harm, lower perceived risk of addiction, and greater intentions to try IQOS (p’s &lt; .05).

Conclusions
Detailed information on reduced exposure in IQOS advertising may convey reduced risk and potentially promote uptake of IQOS among young adults who smoke and attend to this content.

Implications
Findings from this exploratory, single-exposure study demonstrate differences in young adults’ attention to reduced exposure claims in an IQOS advertisement based on their smoking status. Among those who smoke, greater attention to detailed reduced exposure information was associated with reduced perceptions of harm compared to cigarettes, and greater intentions to try IQOS. Findings suggest that among young adults who smoke cigarettes and visually engage with this content, detailed text containing IQOS’ authorized reduced exposure claims is interpreted as reduced risk information and may promote uptake of this product.
The challenge of devolved English governance and the rise of political spatial inequality
Authors: Warner Sam , Newman Jack , Diamond Patrick , Richards Dave 
Published: August 2024

AbstractThe UK is characterised by spatial inequality between and within regions, alongside an over-centralised asymmetric model of governance. In England especially, these features are stark, and throughout the last decade, politicians have responded by forging a distinctive programme of English devolution focused on city-regions. In this article, we analyse the core drivers of the English devolution agenda to understand its impact on the future trajectory of British politics. We identify the predominance of a narrow economic vision of devolution that systematically negates other agendas. The result is a failure to address the trade-offs inherent in the devolution process, alongside an inadequate engagement with the growing demand for democratic revitalisation. In the long-term, we argue that the empowerment of the largest cities in England and the relative neglect of non-urban areas will exacerbate power asymmetries within the UK political system in both centre-periphery and centre-local relations, a phenomenon we term ‘political spatial inequality’. There is a risk of resurgent ‘territorially based populism’ stemming from this uneven political geography which has the potential to exacerbate political instability and significantly reshape UK politics in the wake of Brexit. English devolution is a prescient example of how policy ‘solutions’ can in turn create new problems that pose major challenges for policymakers.