bluuebunny/crossref_metadata_2025_split huggingface dataset:
First soft body morphological data on the tracemaker of the endolithic bryozoan trace fossil Terebripora ramosa d'Orbigny, 1842
Authors: Decker Sebastian H. , Aguilera Felipe , Saadi Ahmed J. , Schwaha Thomas 
Published: August 2024

AbstractTerebriporidae is one of the four extant endolithic ctenostome bryozoan families, with colonies immersed into carbonate substrates like molluscan shells. This monogeneric family comprises 17 species, with 11 extant and 6 fossil species. It is currently considered closely related to vesicularioid ctenostomes, a group characterized by colonies interconnected by polymorphic stolons and a distinct gizzard as part of their digestive systems. However, confusion persists regarding the correct species identities and affiliations of many terebriporid species, and even the description of the entire family is based solely on a few external features of their boring traces, rendering the family an ichnotaxon (trace fossil). Our molecular analysis does not support a vesicularioid affinity, but corroborate a close relationship to Immergentia, another genus of boring bryozoans. Consequently, this study aims to untangle the systematic confusion surrounding Terebriporidae by examining the tracemaker of the type species of the family, Terebripora ramosa from Chile, and investigating its morphology and histology using modern techniques. The current analysis could not confirm typical vesicularioid characters such as a gizzard or true polymorphic stolons. Instead, all characters point towards a closer relationship to Immergentiidae as suggested by a recent molecular phylogeny. In fact, these two taxa share several characters such as cystid appendages and duplicature bands, and appear closely related, with the only difference being a characteristic vane with tubulets present in the tracemaker of T. ramosa. The sister‐group relationship of the tracemaker and the genus Immergentia infers that these borers share a common boring ancestor, but also emphasizes that additional species from the ichnogenus Terebripora need to be studied for more clarity.
The relevance of ultradeep sequencing for low HIV‐1 viral loads and proviruses in the clinical setting
Authors: Foury Alizée , Saunier Aline , Taverniers Audrey , Pinet Nathalie , Josse Thomas , Jeanmaire Eliette , Emilie Caroline , Schvoerer Evelyne , Hartard Cédric 
Published: August 2024

AbstractImproving the therapeutic management of HIV‐positive persons is a major public health issue and includes better detection of drug resistance mutations (DRMs). The aim of this study was (i) to explore DRMs in HIV‐1‐positive persons presenting a blood viral load (VL) < 1000 genomes copies (gc)/mL, including the analyze of cerebrospinal fluid (CSF) and HIV‐DNA from peripheral blood mononuclear cells using ultradeep sequencing (UDS) and (ii), to evaluate how these DRMs could influence the clinical practices. For each patient (n = 12), including five low‐VL patients (i.e., <1000 gc/mL), HIV‐1 UDS targeting the protease, reverse transcriptase and integrase genes was performed on plasma, proviral DNA, and CSF when available. Sequencing discordances or failures were mostly found in samples from low‐VL patients. A 5% UDS cut‐off allowed to increase the sensitivity to detect DRMs in different compartments, excepted in CSF. Patients with the highest viral quasispecies heterogeneity were naïve of treatment or presented a medical history suggesting low selection pressure or virological failures. When analyzing compartmentalization and following‐up patients: low‐frequency variants (LFVs) were responsible for 47% (n = 8) and 76% (n = 13) of changes in drug resistance interpretation, respectively. In such cases, we conclude that UDS is a robust technique, which still could be improved by increase the RNA and/or DNA extraction in low‐VL samples to detect LFVs. Further studies are needed to define the impact of LFVs on antiretroviral treatments. At last, when considering a DRM, the use of mutational load would probably be more suitable than frequencies.
Effect of race/ethnicity on survival in surgically treated intermediate/high risk non‐metastatic clear cell renal carcinoma
Authors: Piccinelli Mattia Luca , Garcia Cristina Cano , Panunzio Andrea , Tappero Stefano , Barletta Francesco , Incesu Reha‐Baris , Tian Zhe , Luzzago Stefano , Mistretta Francesco A. , Ferro Matteo , Saad Fred , Shariat Shahrokh F. , Graefen Markus , Briganti Alberto , Terrone Carlo , Antonelli Alessandro , Chun Felix K. H. , de Cobelli Ottavio , Musi Gennaro , Karakiewicz Pierre I. 
Published: August 2024

AbstractPurposeIt is unknown to what extent 10‐year overall survival of radical nephrectomy treated intermediate/high‐risk non‐metastatic clear cell renal carcinoma patients differs from age‐ and sex‐matched population‐based controls, especially when race/ethnicity is considered (Caucasian vs. African American vs. Hispanic vs. Asian/Pacific Islander).MethodsWe relied on the SEER database (2004–2018) to identify newly diagnosed radical nephrectomy treated intermediate/high risk non‐metastatic clear cell renal carcinoma patients. For each case, we simulated an age‐ and sex‐matched control relying on Social Security Administration Life Tables with 10 years of follow‐up. We compared overall survival between renal carcinoma cases and population‐based controls. Multivariable competing risks regression models tested for predictors of cancer‐specific mortality versus other‐cause mortality.ResultsOf 6877 radical nephrectomy treated intermediate/high risk non‐metastatic clear cell renal carcinoma patients, 5050 (73%) were Caucasian versus 433 (6%) African American versus 1002 (15%) Hispanic versus 392 (6%) Asian/Pacific Islanders. At 10 years, overall survival difference between radical nephrectomy treated intermediate/high risk non‐metastatic clear cell renal carcinoma patients versus population‐based controls was greatest in African Americans (51% vs. 81%, Δ = 30%), followed by Hispanics (54% vs. 80%, Δ = 26%), Asian/Pacific Islanders (56% vs. 80%, Δ = 24%) and Caucasians (52% vs. 74%, Δ = 22%). In competing risks regression, only African Americans exhibited significantly higher other cause mortality (hazard ratio = 1.3; 95% confidence interval = 1.1 – 1.6; p = 0.01) than others.ConclusionRelative to Life Tables' derived sex‐ and age‐matched controls, radical nephrectomy treated intermediate/high‐risk non‐metastatic clear cell renal carcinoma patients exhibit worse overall survival, with worst overall survival recorded in African Americans of all race/ethnicity groups.
Prognostic implications of margin status in association with systemic treatment in a cohort study of patients with resection of colorectal liver metastases
Authors: Moaven Omeed , Mainali Bigyan B. , Valenzuela Cristian D. , Russell Gregory , Cheung Tanto , Corvera Carlos U. , Wisneski Andrew D. , Cha Charles H. , Stauffer John A. , Shen Perry 
Published: August 2024

AbstractBackgroundThis study investigates the impact of margin status after colorectal liver metastasis (CLM) resection on outcomes of patients after neoadjuvant treatment versus those who underwent upfront resection.MethodsAn international collaborative database of CLM patients who underwent surgical resection was used. Proportional hazard regression models were created for single and multivariable models to assess the relationship between independent measures and median overall survival (mOS).ResultsR1 was associated with worse OS in the neoadjuvant group (mOS: 51.8 m for R0 vs. 26.0 m for R1; HR: 2.18). In the patients who underwent upfront surgery, R1 was not associated with OS. (mOS: 46.7 m for R0 vs. 42.6 m for R1). When patients with R1 in each group were stratified by adjuvant treatment, there was no significant difference in the neoadjuvant group, while in the upfront surgery group with R1, adjuvant treatment was associated with significant improvement in OS (mOS: 42.6 m for adjuvant vs. 25.0 m for no adjuvant treatment; HR: 0.21).ConclusionR1 is associated with worse outcomes in the patients who receive neoadjuvant treatment with no significant improvement with the addition of adjuvant therapy, likely representing an aggressive tumor biology. R1 did not impact OS in patients with upfront surgery who received postoperative chemotherapy.
The Role of Socioeconomic Status in Patients With Cutaneous Melanoma of the Head and Neck
Authors: William Stout R. , Gallo Nina , Torres‐Small Sofia , Okose Okenwa , Zhao Chenhao , Hayes Tristan , Gleysteen John , Wood C. Burton 
Published: August 2024

ObjectiveTo determine the effects of socioeconomic status (SES) on cutaneous melanoma of the head and neck.Data SourceSurveillance Epidemiology and End Results (SEER) Program.Review MethodsWe conducted a retrospective analysis of patients diagnosed with cutaneous melanoma of the head and neck from 2006 to 2018, utilizing population‐based data including socioeconomic status (SES) assessed by the US‐based Yost quintile index. SES quintiles ranged from Group 1 (lowest) to Group 5 (highest). We examined disease severity at diagnosis (stage, Breslow thickness, and spread) and survival outcomes (overall survival, cause‐specific survival) to assess the impact of SES.ResultsA total of 53,967 melanomas of the head and neck were identified (14,146 females; 39,821 males; 51,890 white; 125 black; 317 other). Group 1 patients had a significantly higher percentage of end‐stage disease (stage IV) at diagnosis (n = 101; 3.2% vs. n = 280; 1.9%, respectively) (p < .001), increased Breslow thickness (.80 mm vs .60 mm, respectively) (p < .001), and higher percentage of distant disease (n = 152; 3.6% vs. n = 431; 2.1%, respectively) (p < .001). Group 1 patients experienced a higher death rate from melanoma than group 5 patients (n = 585; 14% vs n = 1,753; 8.6%). Survival increased with SES.ConclusionsWhen evaluating cutaneous melanoma of the head and neck, low SES is related to more severe disease at diagnosis and worse survival outcomes. Addressing the underlying causes of this relationship could lead to more equitable management and survival outcomes.Level of EvidenceIII Laryngoscope, 2024
What motivates crypto likes? How assessment regulatory mode increases social media engagement with crypto assets
Authors: Mathmann Frank , Chrysochou Polymeros , Tiganis Antonios , Martin Brett A. S. 
Published: August 2024

AbstractConsumer engagement with social media posts is extensively examined in the marketing literature, yet the motivations behind engagement with high‐risk financial and digital assets, such as cryptocurrencies, remain unclear. This research explores what drives consumers to engage with social media posts about crypto assets like Bitcoin. Utilizing regulatory mode theory, we demonstrate across four studies that assessment language (motivating thought) versus locomotion (motivating action) increases social media engagement with crypto assets. In two field studies analyzing social media (N = 194,098 posts), we find that assessment results in more Facebook likes on posts about crypto assets. Additionally, two online experiments (N = 1661) establish a causal, positive relationship between assessment language and consumer liking intentions, mediated by perceived investment volatility, cognitive engagement, and positive affect. Managers should use assessment words like “think” and “compare” when communicating about crypto on social media and can leverage our dictionary to identify crypto terms in large text data sets.
A comprehensive overview on the crosstalk between microRNAs and viral pathogenesis and infection
Authors: Bahojb Mahdavi Seyedeh Zahra , Jebelli Asiyeh , Aghbash Parisa Shiri , Baradaran Behzad , Amini Mohammad , Oroojalian Fatemeh , Pouladi Nasser , Baghi Hossein Bannazadeh , de la Guardia Miguel , Mokhtarzadeh Amir Ali 
Published: August 2024

AbstractInfections caused by viruses as the smallest infectious agents, pose a major threat to global public health. Viral infections utilize different host mechanisms to facilitate their own propagation and pathogenesis. MicroRNAs (miRNAs), as small noncoding RNA molecules, play important regulatory roles in different diseases, including viral infections. They can promote or inhibit viral infection and have a pro‐viral or antiviral role. Also, viral infections can modulate the expression of host miRNAs. Furthermore, viruses from different families evade the host immune response by producing their own miRNAs called viral miRNAs (v‐miRNAs). Understanding the replication cycle of viruses and their relation with host miRNAs and v‐miRNAs can help to find new treatments against viral infections. In this review, we aim to outline the structure, genome, and replication cycle of various viruses including hepatitis B, hepatitis C, influenza A virus, coronavirus, human immunodeficiency virus, human papillomavirus, herpes simplex virus, Epstein–Barr virus, Dengue virus, Zika virus, and Ebola virus. We also discuss the role of different host miRNAs and v‐miRNAs and their role in the pathogenesis of these viral infections.
A combinatorial model reduction method for the finite element analysis of wind instruments
Authors: Jeanneteau Marie , Oumaziz Paul , Passieux Jean‐Charles , Gibiat Vincent , Cottier Jonathan 
Published: August 2024

AbstractA high‐fidelity finite element model is proposed for the complete simulation of the time‐harmonic acoustic propagation in wind instruments. The challenge is to meet the extremely high accuracy required by professional musicians, in a complex domain, for all fingerings and over a wide frequency range, within an affordable computational time. Several modelling assumptions are made to limit the numerical complexity of the problem while preserving all relevant physics. A dedicated high‐performance solution strategy is also proposed, based on partitioning, condensation and model order reduction, exploiting the combinatorial nature of wind instrument fingerings. Finally, the proposed approach is applied to the simulation of an alto saxophone. An order of magnitude reduction in memory and computational cost is achieved.
SARS‐CoV‐2 coinfection in children with severe airway obstruction due to pulmonary tuberculosis
Authors: Goussard P. , Van Wyk L. , Venkatakrishna S. , Rabie H. , Schubert P. , Frigati L. , Walzl G. , Burger C. , Doruyter A. , Andronikou S. , Gie A. G. , Rhode D. , Jacobs C. , Van der Zalm M. 
Published: August 2024

AbstractIntroductionThe severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic had a significant impact on tuberculosis (TB) control globally, with the number of new TB diagnoses decreasing. Coinfection with some viruses, especially measles, could aggravate TB in children. This is presumably a result of depressed cellular immunity. Reports on children with TB and SARS‐CoV‐2 coinfection are limited.MethodsA retrospective analysis of children up to 13 years old admitted to Tygerberg Hospital, Cape Town, South Africa, from March 2020 to December 2022 with suspected TB‐induced airway compression requiring bronchoscopy. Children were included if they presented with severe intrathoracic airway obstruction and/or radiographic evidence of complicated TB. The patients were divided into two groups based on SARS‐CoV‐2 respiratory polymerase chain reaction results. Demographics, TB exposure, microbiology, SARS‐CoV‐2 laboratory data, imaging, inflammatory cytokine levels, and bronchoscopy data were collected. Statistical analyses compared SARS‐CoV‐2 positive and negative groups.ResultsOf the 50 children undergoing bronchoscopy for TB airway obstruction, 7 (14%) were SARS‐CoV‐2 positive. Cough was more prevalent in the SARS‐CoV‐2 positive group (p = 0.04). There was no difference in TB culture yield between groups. However, SARS‐CoV‐2 positive children showed slower radiological improvement at 1 month (p = 0.01), pleural effusions (p < 0.001), and a higher need for endoscopic enucleation (p < 0.001). FDG PET/CT scans indicated an ongoing inflammation in the SARS‐CoV‐2 positive group.ConclusionsCoinfection with SARS‐CoV‐2 in children with TB airway obstruction appears to complicate the disease course, necessitating more medical interventions and demonstrating a longer duration of the TB inflammatory process. Further research is needed to understand the impact of viral infections on TB progression and outcomes in pediatric patients.
Ultrasensitive and on‐site diagnosis of rice bakanae disease based on CRISPR‐LbCas12a coupled with LAMP
Authors: Zhang Chao , Zhao Tianyue , Li Jianhang , Liu Xiaoshuang , Wang Wenting , Huang Xuanda , Liu Yu , Sun Yang , Wei Pengcheng 
Published: August 2024

AbstractBACKGROUNDRice bakanae disease (RBD) has longstanding challenges impacted rice production, which is predominantly induced by Fusarium fujikuroi Nirenberg. Early diagnosis of F. fujikuroi is important to control RBD and improve quality and quantity of rice production. This study presents a novel on‐site diagnosis platform combined with CRISPR/LbCas12a and LAMP to detect F. fujikuroi.RESULTSLAMP amplification of TEF1‐α, a characteristic gene of F. fujikuroi were performed, followed with trans‐cleavage reaction of LbCas12a, cleaving the single‐stranded DNA reporter, which is modified by the terminal fluorophore and quencher groups, producing fluorescence signal. The platform was confirmed with high specificity and sensitivity (LOD <1 aM). Furthermore, we designed a lateral flow strip experiment based on the trans‐cleavage activity of LbCas12a, which was identified with similar sensitivity and specificity to the fluorescence detection method.CONCLUSIONIn summary, this study achieved a platform with remarkable sensitivity and specificity for F. fujikuroi detection and provide potential for on‐site and ultrasensitive diagnostic tools for RBD. © 2024 Society of Chemical Industry.
Numerical Investigation of a Coupled Micropillar ‐ Waveguide System for Integrated Quantum Photonic Circuits
Authors: Roche Léo J. , Betz Fridtjof , Yang Yuhui , Limame Imad , Shih Ching‐Wen , Burger Sven , Reitzenstein Stephan 
Published: August 2024

AbstractThe on‐chip resonant excitation of single quantum dots (QDs) via integrated microlasers represents an effective and scalable method for integrated quantum photonics applications based on on‐demand single‐photon emitters. In this study, the design and numerical optimization of the evanescent coupling between whispering gallery modes (WGMs) of a micropillar resonator and a nearby single‐mode ridge waveguide in the Al(Ga)As/GaAs material system are presented. In this study, such systems are examined within a wavelength range of 930 nm, which is suitable for resonant excitation of typical self‐assembled InGaAs quantum dots. In particular, the coupling and the transmitted optical power of a WGM resonator to a ridge waveguide are examined for a range of gap spacings, with the objective of optimizing the photon coupling efficiency and Q‐factor of the monolithically integrated nanophotonic system. The findings of this study enable to identify the best device parameters for subsequent device fabrication. The findings establish a foundation for the production of highly effective photonic quantum circuits through the use of WGM microlasers integrated into evanescently coupled waveguide systems, including resonantly excited single quantum dots.
Ion confinement and separation using asymmetric electrodynamic fields in structures for lossless ion manipulations
Authors: Greer Cullen , Kinlein Zackary R. , Clowers Brian H. 
Published: August 2024

RationaleTW‐SLIM ion mobility separations have demonstrated exceptional resolution by leveraging long paths with minimal loss. All previously reported experiments have used electrode surfaces which are mirrored to generate symmetrically opposing electric fields for ion confinement. However, work with other planar ion optics indicates this may be unnecessary. This study explores conditions under which separations may be obtained using a SLIM with asymmetric electric fields.MethodsThe asymmetric field configuration was defined by applying a uniform DC potential to all electrodes of the top PCB of a standard TW‐SLIM board pair, with no electrode placement modifications. This configuration was simulated in SIMION to assess transmission through the SLIM. A benchtop TW‐SLIM instrument outfitted with a Faraday plate detector was modified likewise, so the top PCB had a uniform DC potential applied to all electrodes, while the bottom board was operated normally.ResultsSimulations show full ion transmission for four different m/z ion populations over a range of DC biases applied to the “pusher” board. Likewise, the modified benchtop instrument is capable of transmitting, separating, and cycling ions with minimal losses. The effect of pusher strength on separation quality is explored, and comparisons between the standard and modified SLIM are made with respect to resolving the +2 and +3 charge states of neurotensin ions.ConclusionsA functional IMS instrument using asymmetric confining fields demonstrates additional field modifications may be a means to achieve additional functionality with limited interruption of the analysis. A TW‐SLIM PCB specifically designed as a pusher board would benefit from minimized manufacturing cost, simplifying assembly, reducing drive electronics, and improved field consistency.
Isolated recurrent metastatic pulmonary nodule from the kidney: An extraordinarily long interval
Authors: Kim Cheong , Lee Hwan Jin , Jang Kyu Yun , Park Jun Hyung , Jeong Jae Seok , Lee Yong Chul 
Published: August 2024

Key messageOur case highlights the importance of follow‐up. Previous meta‐analysis has shown that patients with sub‐centimetre nodules may have extended follow‐up intervals before requiring intervention, unlike those with larger nodules exceeding 1 cm. However, referring to our case, we can see the importance of regular and dense follow‐up.