bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sex Differences Between cT4b and pT4b Rectal Cancers
Authors: Komori Koji , Kimura Kenya , Kinoshita Takashi , Sano Tsuyoshi , Ito Seiji , Abe Tetsuya , Senda Yoshiki , Misawa Kazunari , Ito Yuichi , Uemura Norihisa , Shimizu Yasuhiro 
Published: August 2013

Abstract
We retrospectively evaluated rectal cancer surgery cases in which resection had been performed for invasion of other organs in terms of pathologic findings from the viewpoint of sex differences. We enrolled 61 consecutive patients with rectal cancer who had undergone curative surgery with resection of invaded adjacent organs. We investigated invasion of adjacent organs in terms of pathologic findings according to sex differences. Among males, 4 cases (13.8%) had received combined radical resections of more than 2 organs, while the number of such female cases was 15 (46.9%). The difference between males and females was statistically significant (P = 0.006). Among male cases, histopathologic invasion was present in 4 (13.8%), while 9 female cases (28.1%) showed this feature. Nevertheless, there was not a statistically significant difference between males and females (P = 0.08); the rate in females was roughly twice that in males. No significant difference was recognized in the overall survival rates between males and females, but more females than males experienced local recurrence. In cases with rectal cancer invading neighboring organs, the effect of the invasion must be carefully determined, and the most appropriate operative approach selected accordingly.
Clinical and Pathologic Prognostic Factors That Are Influential in the Survival and Prognosis of Lung Adenocarcinomas and Invasive Predominant Subtypes
Authors: Zeybek Arife , Toru Serap , Özbudak İrem Hicran , Sarper Alpay , Oz Necdet , Bozcuk Hakan , Özbilim Gülay , Demircan Abid 
Published: August 2013

Abstract
Therapeutic approaches to lung adenocarcinomas differ because of their heterogeneous morphologies, prognoses, and clinical features. For this reason, new histopathologic classifications for lung adenocarcinomas were done by the International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society to form subtypes with homogeneous prognoses. There are limited clinical data in the literature on the prognosis of the subgroups formed according to the new classification. A total of 86 patients with adenocarcinoma who had undergone pathologic stages I and II curative resection and mediastinal lymph node dissection were retrospectively analyzed according to the seventh TNM staging system revised by the Union for International Cancer Control/American Joint Committee on Cancer. Histologic subtyping was reassessed according to the dominant histopathologic morphology. When survival rates of lung adenocarcinomas were compared according to their localizations, it was observed that adenocarcinomas localized to the right hemithorax had a longer survival than the ones with left hemithorax localization (P = 0.026). When necrosis was taken into account, it was seen that necrosis rate was higher in solid predominant type compared with other types, whereas it was lower in acinary type (P = 0.046). When peritumoral lymphovascular invasion data were assessed, it was observed that disease-free survival was influenced in a negative fashion (P = 0.018). New histopathologic classification of adenocarcinomas has been a step forward to attaining homogeneous groups, but when the biologic heterogeneity of the adenocarcinomas is taken into account, the authors believe that considering the peritumoral lymphatic vascular invasion, left hemithorax localization, and tumoral necrosis entities in the upcoming TNM classification will contribute to evaluating the prognosis.
Impact of Less Invasive Treatments Including Sclerotherapy With a New Agent and Hemorrhoidopexy for Prolapsing Internal Hemorrhoids
Authors: Tokunaga Yukihiko , Sasaki Hirokazu 
Published: August 2013

Abstract
Conventional hemorrhoidectomy is applied for the treatment of prolapsing internal hemorrhoids. Recently, less-invasive treatments such as sclerotherapy using aluminum potassium sulphate/tannic acid (ALTA) and a procedure for prolapse and hemorrhoids (PPH) have been introduced. We compared the results of sclerotherapy with ALTA and an improved type of PPH03 with those of hemorrhoidectomy. Between January 2006 and March 2009, we performed hemorrhoidectomy in 464 patients, ALTA in 940 patients, and PPH in 148 patients with second- and third-degree internal hemorrhoids according to the Goligher's classification. The volume of ALTA injected into a hemorrhoid was 7.3 ± 2.2 (mean ± SD) mL. The duration of the operation was significantly shorter in ALTA (13 ± 2 minutes) than in hemorrhoidectomy (43 ± 5 minutes) or PPH (32 ± 12 minutes). Postoperative pain, requiring intravenous pain medications, occurred in 65 cases (14%) in hemorrhoidectomy, in 16 cases (1.7%) in ALTA, and in 1 case (0.7%) in PPH. The disappearance rates of prolapse were 100% in hemorrhoidectomy, 96% in ALTA, and 98.6% in PPH. ALTA can be performed on an outpatient basis without any severe pain or complication, and PPH is a useful alternative treatment with less pain. Less-invasive treatments are beneficial when performed with care to avoid complications.
Laparoscopy-Assisted Distal Gastrectomy for an Early Gastric Cancer Patient With Situs Inversus Totalis
Authors: Fujikawa Hirohito , Yoshikawa Takaki , Aoyama Toru , Hayashi Tsutomu , Cho Haruhiko , Ogata Takashi , Shirai Jyunya , Oshima Takashi , Yukawa Norio , Rino Yasushi , Masuda Munetaka , Tsuburaya Akira 
Published: August 2013

Abstract
Situs inversus totalis (SIT) is a congenital condition in which there is complete right to left reversal of the thoracic and abdominal organs. This report describes laparoscopy-assisted distal gastrectomy (LADG) for an early gastric cancer patient with SIT. The preoperative diagnosis was c-stage IA (cT1a cN0 cH0 cP0 cM0). LADG with D1+ dissection and Billroth-I reconstruction was successfully performed by standing at the opposite position. The operating time was 234 minutes and blood loss was 5 mL. Although a mechanical obstruction occurred after surgery, the patient recovered after re-operation with Roux-en-Y bypass.
Significance of Tumor Length as Prognostic Factor for Esophageal Cancer
Authors: Zeybek Arife , Erdoğan Abdullah , Gülkesen Kemal Hakan , Ergin Makbule , Sarper Alpay , Dertsiz Levent , Demircan Abid 
Published: August 2013

AbstractOur study indicated the relationship between tumor length and clinicopathologic characteristics as well as long-term survival in esophageal cancer. A total of 116 patients who underwent curative surgery for thoracic esophageal cancer with standard lymphadenectomy in 2 fields between 2000 and 2010 were included in the study. The medical records of these patients were retrospectively reviewed. The patients with tumor length ≥3 cm had a highly significant difference in the involvement of adventitia and lymph node stations. The patients with tumor length ≤3 cm had significantly lower rates of involvement of the adventitia and lymph node stations. Tumor length could have a significant impact on both the overall survival and disease-free survival of patients with resected esophageal carcinomas and may provide additional prognostic value to the current tumor, node, and metastasis staging system before patients receive any cancer-specific treatment.
Laparoscopic Resection of a Retroperitoneal Liposarcoma: A Case Report and Review of the Literature
Authors: Nomura Ryohei , Tokumura Hiromi , Matsumura Naoki 
Published: August 2013

AbstractHere, we describe a case of a retroperitoneal liposarcoma successfully managed by laparoscopic surgery. A 72-year-old man underwent abnormal hypertension screening using computed tomography (CT), which revealed a low-density mass measuring 7 cm in diameter in the retroperitoneal space. We diagnosed the mass as a liposarcoma before the operation. The mass was resected laparoscopically. No perioperative complications were encountered, and the patient was discharged on the fourth postoperative day. The pathologic diagnosis was well-differentiated liposarcoma, indicating complete surgical resection. Thus, we conclude that a laparoscopic approach for the patients with retroperitoneal tumors, including liposarcomas, is safe, feasible, and minimally invasive, even if there is a possibility of the tumor being malignant.
Hypothenar hammer syndrome: A multicenter case–control study
Authors: Scharnbacher Jutta , Claus Matthias , Reichert Jörg , Röhrl Tobias , Hoffmann Ulrich , Ulm Kurt , Letzel Stephan , Nowak Dennis 
Published: August 2013

AbstractBackgroundThe rarely diagnosed hypothenar hammer syndrome (HHS) is due to vascular damage to the distal part of the ulnar artery probably caused by acute or repetitive blunt trauma to the hypothenar region. To date, mainly case reports have been published, while epidemiological data are almost absent.AimTo identify potential risk factors for HHS.MethodAn interview‐based multicenter case–control study of 71 patients with HHS and 105 matched controls was conducted with standardized questions regarding disease specific variables, occupation, exposure of the hands to different types of trauma in occupational and leisure context. Medical data were verified from individual medical records.ResultsMultivariable logistic regression analysis revealed that using the hand as a hammer on a daily basis (adjusted odds ratio [aOR] 17.04, 95% CI 5.51–52.67) daily pressure to the palm of the hand (aOR 4.96, 95% CI 1.39–17.71), and daily exposure to vibrating tools (aOR 3.41, 95% CI 1.03–11.31) were significant risk factors for HHS.ConclusionsThis investigation represents one of the largest groups of patients with HHS described so far. Work‐related repeated blunt trauma to the palm of the hand significantly increases the risk of HHS. Am. J. Ind. Med. 56:1352–1358, 2013. © 2013 Wiley Periodicals, Inc.
Diffusing capacity and forced vital capacity in 5,003 asbestos‐exposed workers: Relationships to interstitial fibrosis (ILO profusion score) and pleural thickening
Authors: Miller Albert , Warshaw Raphael , Nezamis James 
Published: August 2013

AbstractBackgroundAsbestosis is an interstitial lung disease whose radiographic severity has long been graded by the International Labour Office (ILO) profusion score. Its effect on pulmonary function is further impacted by asbestos related pleural thickening.ObjectivesThis report aims to describe the relationships between radiographic grading of interstitial and pleural fibrosis and a key test of pulmonary function, the diffusing capacity, which measures gas exchange and has rarely been assessed in large groups, and to confirm the relationship to an independent test of pulmonary function, the vital capacity, which measures a mechanical property of the lungs.MethodsThe data were derived from a survey during the period 1997–2004 of 5,003 workers (all white males) exposed to asbestos in various trades. Tests included chest radiographs read by a certified expert (“B”) reader, forced vital capacity (FVC), and carbon monoxide diffusing capacity (DLco). Cigarette smoking was adjusted for in the predictive equation for DLCO. Workers were evaluated at a mobile facility at work sites in four southern states.ResultsBoth diffusing capacity and vital capacity were negatively correlated with profusion score over the full spectrum of radiographic severity. ILO profusion scores 0/1 (conventionally classified as normal) and 1/0 (conventionally classified as abnormal) were associated with similar diffusing capacity and vital capacity values. The highest profusion scores were associated with a greater proportionate decrease in diffusing capacity than in FVC. Both tests showed an effect of pleural fibrosis.ConclusionsBoth radiographic severity graded by the profusion score and pleural thickening are correlated with two independent measures of pulmonary function. FVC (which had been reported in smaller work forces) and DLCO (which has not been reported). Both measures show a decrease from normal to intermediate (0/1, 1/0) scores and a further decrease with greater scores, demonstrating the consistency of radiographic and functional assessments. Am. J. Ind. Med. 56:1383–1393, 2013. © 2013 Wiley Periodicals, Inc.
Total serum immunoglobulin E as a marker for missed antigens on in vitro allergy screening
Authors: Hatcher Jeanne L. , Cohen Samuel D. , Mims J. Whit 
Published: August 2013

BackgroundThe diagnosis of inhalant allergies involves a medical history, physical exam, and allergen sensitivity testing; allergen sensitivity can be assessed by a specific immunoglobulin E (IgE) screen for inhalant allergens. Some patients with clinical suspicion for inhalant allergies have a negative specific IgE screen, but high total IgE. We theorize that elevated total IgE may indicate a false‐negative screen caused by “missed allergens” not initially identified.MethodsStudy patients with a negative allergy screen and elevated IgE (>116 kU/L) were identified (n = 26). Control patients (n = 26) were defined as having a negative screen and an IgE <2.95 kU/L. Both groups were tested with an expanded specific IgE panel and completed a questionnaire about other causes of elevated IgE.ResultsThe expanded panel was positive for inhalant allergens in 4 study patients (15%) and 0 control patients (p = 0.037). Within the study patients, 50% had asthma and 76.9% had chronic sinusitis. Only 2 control patients had asthma (11.5%), p = 0.003; 4 (19.2%) reported chronic sinusitis, p < 0.0001. Food allergen sensitivity was identified in 5 study patients and 1 control, p = 0.083.ConclusionThis pilot study evaluated patients clinically suspected of allergy with a negative inhalant IgE screen. Those with a high total IgE were more likely to have a missed inhalant allergen on expanded testing, as well as asthma and chronic sinusitis, compared to those with a low total IgE. Further investigation of “missed antigen” and the role of chronic respiratory inflammatory disease in patients with elevated total IgE is warranted.
Preparation and adsorption behaviors of ethylene diamine tetraacetic acid modified zwitterionic hybrid materials
Authors: Zhao Donglin , Liu Chen , Liu Junsheng , Zou Jing , Li Meng 
Published: August 2013

ABSTRACTNovel ethylene diamine tetraacetic acid (EDTA)‐modified zwitterionic hybrid materials were prepared via a sol–gel process. Their adsorption performances for Pb2+ ions were examined. Fourier transform infrared spectroscopy confirmed the reaction products. Thermogravimetric analysis revealed that the thermal stability of these hybrid materials could reach 200°C. Differential scanning calorimetry measurement showed that the addition of titanium butoxide could impact the crystallization transformation of these materials. Field emission scanning electron microscopy images showed that EDTA modification induced a decrease in the particle size. Adsorption experiments demonstrated that the optimal initial pH was 5. Moreover, we observed that the adsorptions for Pb2+ ions followed the Lagergren pseudo‐second‐order kinetic model, intraparticle diffusion, and Langmuir isotherm model. In addition, we found that the maximal Langmuir constant was 0.86 mmol/g. The negative Gibbs free energy values suggested that Pb2+ adsorption onto these samples was spontaneous in nature. The desorption experiment indicated that these samples could be recovered with aqueous HCl solution as a desorbent. These results suggest that the synthesized EDTA‐modified zwitterionic hybrid materials are promising adsorbents that could be used to separate and recover heavy‐metal ions from polluted wastewater. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 39801.
Understanding the Unconventional Effects of Halogenation on the Luminescent Properties of Oligo(Phenylene Vinylene) Molecules
Authors: Sun Chun‐Lin , Li Jun , Geng Hong‐Wei , Li Hui , Ai Yong , Wang Qiang , Pan Shan‐Lin , Zhang Hao‐Li 
Published: August 2013

AbstractIt is commonly known that halogenation tends to decrease the luminescence quantum yield of an organic dye, owing to the high electronegativity and heavy‐atom effect of the halogen atom. However, based on an investigation of the effects of halogenation on the luminescence of the oligo(phenylene vinylene) (OPV) framework, we demonstrate that halogenation can have positive impact on the solid‐state fluorescence and electrochemiluminescence (ECL) properties of OPV derivatives. The chlorinated OPV exhibits a very high solid‐state fluorescence quantum yield (91 %), whilst the brominated analogue gives the highest ECL emission intensity. Time‐dependent density functional theory calculations, natural bond orbital analysis, and natural transition orbital analysis were performed to assist the understanding of the origin of these positive halogenation effects, which provide insight into the rational design of highly luminescent halogenated organic materials for solid‐state devices and ECL applications.
Predicting complex phenotype–genotype interactions to enable yeast engineering: Saccharomyces cerevisiae as a model organism and a cell factory
Authors: Dikicioglu Duygu , Pir Pınar , Oliver Stephen G. 
Published: August 2013

AbstractThere is an increasing use of systems biology approaches in both “red” and “white” biotechnology in order to enable medical, medicinal, and industrial applications. The intricate links between genotype and phenotype may be explained through the use of the tools developed in systems biology, synthetic biology, and evolutionary engineering. Biomedical and biotechnological research are among the fields that could benefit most from the elucidation of this complex relationship. Researchers have studied fitness extensively to explain the phenotypic impacts of genetic variations. This elaborate network of dependencies and relationships so revealed are further complicated by the influence of environmental effects that present major challenges to our achieving an understanding of the cellular mechanisms leading to healthy or diseased phenotypes or optimized production yields. An improved comprehension of complex genotype–phenotype interactions and their accurate prediction should enable us to more effectively engineer yeast as a cell factory and to use it as a living model of human or pathogen cells in intelligent screens for new drugs. This review presents different methods and approaches undertaken toward improving our understanding and prediction of the growth phenotype of the yeast Saccharomyces cerevisiae as both a model and a production organism.
Temperature‐induced conformational transition of bovine serum albumin in neutral aqueous solution by reversed‐phase liquid chromatography
Authors: Bian Liujiao , Wu Dan , Hu Wei 
Published: August 2013

ABSTRACTThe temperature‐induced conformational transition of bovine serum albumin (BSA) in neutral aqueous solution was studied using intrinsic fluorescence emission spectrum, reversed‐phase liquid chromatography and sodium dodecyl sulfate–polyacrylamide gel electrophoresis, and the conformation transition thermodynamic parameters were determined in the temperature range 12–50 °C. The results showed that, in the temperature range 12–20 °C, BSA only existed in a single conformation state A, while in the temperature range 22–50 °C, it existed in two different conformation states: A and B. The percentage of conformation state A decreased while that of conformation state B increased with the increase in temperatures, and when temperature approached 50 °C conformation state B accounted for approximately 25% of all conformation states of BSA. In the conformational transition of BSA from conformation state A to conformation state B, the positive enthalpy change, entropy change and free energy changes demonstrated that the conformational transition was endothermic, nonspontaneous and mainly entropy‐driven. © 2013 The Authors. Biomedical Chromatography published by John Wiley & Sons, Ltd.
Environmental Orientation and Economic Performance: a Quasi‐experimental Study of Small Swedish Firms
Authors: Linder Marcus , Björkdahl Joakim , Ljungberg Daniel 
Published: August 2013

ABSTRACTThis paper investigates the relationship between the environmental orientation and economic performance of small firms. We conduct a quantitative analysis on a sample of 299 environmentally oriented and all other small (2–49 employees) Swedish firms. We estimate the effect of environmental orientation on profit margin to examine how environmentally oriented firms perform in relation to non‐environmentally oriented firms. To do this, we employ a quasi‐experimental design in which we create a control group of non‐environmentally oriented firms that are very similar to their environmentally oriented counterparts. We use two measures of environmental orientation: (i) a third‐party classification, and (ii) a self‐assessment of environmental differentiation. The findings show a negative effect of environmental orientation on economic performance. Our contribution to the literature is in using a novel and more rigorous way to measure the relationship between environmental orientation and economic performance and providing implicit support for the existence of a causal link from economic performance to environmental orientation. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment
The Effect of Bituminous and Lignite Ash on the Performance of Ilmenite as Oxygen Carrier in Chemical‐Looping Combustion
Authors: Azis M. M. , Leion H. , Jerndal E. , Steenari B.‐M. , Mattisson T. , Lyngfelt A. 
Published: August 2013

AbstractThe influence of ash in chemical‐looping combustion (CLC) has been studied in a lab‐scale fluidized bed reactor. The oxygen carrier, ilmenite, was investigated with German lignite coal, Chinese bituminous coal, Mexican pet coke, wood char, and methane. Lignite ash and ash from gasified Chinese bituminous coal were compared in this study. Up to 50 wt % and 33.3 wt % loadings of ash from the combustion of lignite and ash from the gasification of coal were added. The gas conversion was clearly affected by the addition of ash, and very similar results were seen both for methane conversion and for CO conversion in the solid fuel tests. Thus, both ashes showed initial decrease in gas conversion with the addition of some ash due to the presence of inert/deactivating material in the ashes. At higher ash loading, a beneficial effect of ash could be seen. Furthermore, no negative effect of ash addition on the fluidizability of the bed material could be seen.
Ca(OH)2‐Based Calcium Looping Process Development at The Ohio State University
Authors: Phalak N. , Wang W. , Fan L.‐S. 
Published: August 2013

AbstractThe cyclic calcium oxide‐calcium carbonate (CaO‐CaCO3) process is a promising option for large‐scale CO2 control. Important advantages include high‐temperature operation, inexpensive sorbent feedstock, and high CO2 capture capacity of CaO. However, decreasing sorbent reactivity over multiple cycles, due to high‐temperature sintering, presents a major challenge for further progress. The Ohio State University (OSU) has led the development of a novel three‐step calcium looping (CaO‐Ca(OH)2‐CaCO3) process for post‐ and precombustion CO2 capture. An overview of OSU's work is provided, highlighting the differences in this approach when compared to competing efforts in this field.
Thermodynamic Evaluation and Cold Flow Model Testing of an Indirectly Heated Carbonate Looping Process
Authors: Junk M. , Reitz M. , Ströhle J. , Epple B. 
Published: August 2013

AbstractCarbon capture with subsequent compression and storage is a promising possibility for the reduction of CO2 emissions from coal‐fired power generation. A very efficient post‐combustion CO2 capture technology is the carbonate looping process. To further increase the process efficiency, a new concept is considered where the heat for calcination is transferred from an external combustor to the calciner by means of heat pipes. Some thermodynamic evaluations for a retrofit of a coal‐fired host plant with the indirectly heated carbonate looping process and cold flow model tests of a 300‐kWth test facility that will be erected in 2013 in Darmstadt are presented.