bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictors of changes in health status between and within patients 12 months post left ventricular assist device implantation
Authors: Brouwers Corline , de Jonge Nicolaas , Caliskan Kadir , Manintveld Olivier , Young Quincy‐Robyn , Kaan Annemarie , Kealy Jennifer , Denollet Johan , Pedersen Susanne S. 
Published: March 2014

BackgroundImproving patient‐reported outcomes (e.g. health status) has become an important goal in left ventricular assist device (LVAD) therapy, in addition to reducing mortality and morbidity. We examined predictors of changes in health status scores between and within patients 12 months post LVAD implantation.MethodsHealth status [Kansas City Cardiomyopathy Questionnaire (KCCQ); Short‐Form 12 (SF‐12)] were assessed at 3–4 weeks after implantation, and at 3, 6 and 12 months follow up in 54 LVAD patients (74% men; mean age 54 ± 9 years).ResultsPatients experienced significant improvements in health status between baseline and 3 months follow‐up as assessed by the KCCQ (clinical summary score: F = 33.49, P < 0.001; overall summary score: F = 31.13, P < 0.001) and the SF‐12 (physical component score: F = 31.59, P < 0.001; mental component score: F = 21.77, P < 0.001), but not between 3 months and 12 months follow‐up (P > 0.05 for all). Higher scores on anxiety and depression over time, older age, lower ejection fraction, and more co‐morbidity were associated with poorer health status scores on one or both of the KCCQ and SF‐12 subscales. The majority of the between‐patient variance of the mental component summary scores (82.6%), but not the KCCQ overall summary score (41.9%), KCCQ clinical summary score (36.2%) and physical component summary scores (23.2%), was explained by the sociodemographic, clinical and psychological factors.ConclusionThe majority of LVAD patients show a significant improvement in health status after LVAD implantation. However, there are large differences in individual health status score trajectories which are only partly explained by measures of disease severity pre‐LVAD, co‐morbidity and psychological stress.
First Report for Electrochemical Determination of Levodopa and Cabergoline: Application for Determination of Levodopa and Cabergoline in Human Serum, Urine and Pharmaceutical Formulations
Authors: Tajik Somayeh , Taher Mohammad Ali , Beitollahi Hadi 
Published: March 2014

AbstractThe electrochemical oxidation of levodopa on the surface of a carbon paste electrode modified with graphene nanosheets, 1‐(4‐bromobenzyl)‐4‐ferrocenyl‐1H‐[1,2,3]‐triazole (1,4‐BBFT) and hydrophilic ionic liquid (n‐hexyl‐3‐methylimidazolium hexafluoro phosphate) as a binder is studied. It has been found that the oxidation of levodopa at the surface of a modified electrode occurs at a potential of about 210 mV less positive than that of an unmodified carbon paste electrode (CPE). The prepared modified electrode exhibits a very good resolution of the voltammetric peaks of levodopa and cabergoline. The electrode has been applied successfully for the determination of levodopa and cabergoline in some real samples.
Monacolin K production by citrinin‐free Monascus pilosusMS‐1 and fermentation process monitoring
Authors: Feng Yanli , Shao Yanchun , Zhou Youxiang , Chen Fusheng 
Published: March 2014

Monacolin K (MK) is a naturally occurring hypocholesterolemic agent that specifically inhibits HMG‐CoA reductase. As a natural source of MK, Monascus‐fermented products are of special interest; however, some Monascus strains could produce citrinin, which is a nephrotoxin, as a contaminant in Monascus‐derived products. A Monascus pilosus strain (MS‐1) that produces high amounts of MK, but no citrinin, was screened in previous investigations. Herein, liquid‐state fermentation parameters of the MS‐1 strain were optimized using statistical methods to maximize the MK yield with potato juice as a basic medium. The maximum MK yield (326.74 μg/mL) was predicted with 50 mL of medium in a 250‐mL conical flask containing 30 g/L sucrose, 38.75 g/L soybean flour, 0.00105 mol/L Mg2+ at pH 5.48, and 8% v/v seed inoculum precultured for 42 h at 30°C, incubated at 30°C for 3 days, followed by further incubation for 11 days at 24.7°C. The verified MK yield was 390.68 μg/mL and the MK yield increased to 565.64 μg/mL after 21 days of fermentation. No citrinin was detected in MS‐1‐fermented products. The results suggest that citrinin‐free MK can be obtained from natural medium through liquid‐state fermentation in an economical way. This method will be of practical value to the industrial production of MK.
Effectiveness of Cognitive Remediation and Emotion Skills Training (CREST) for Anorexia Nervosa in Group Format: A Naturalistic Pilot Study
Authors: Tchanturia Kate , Doris Eli , Fleming Caroline 
Published: March 2014

AbstractObjectiveThis study aims to evaluate a novel and brief skills‐based therapy for inpatients with anorexia nervosa, which addressed ‘cold’ and ‘hot’ cognitions in group format.MethodAdult inpatients with anorexia nervosa participated in the cognitive remediation and emotion skills training groups. Participants who attended all group sessions completed patient satisfaction and self‐report questionnaires.ResultsAnalysis of the data showed that social anhedonia (measured by the Revised Social Anhedonia Scale) decreased significantly between pre‐ and post‐interventions, with small effect size (d = 0.39). Motivation (perceived ‘importance to change’ and ‘ability to change’) was found to have increased with small effect sizes (d = 0.23 and d = 0.16), but these changes did not reach statistical significance. The cognitive remediation and emotion skills training group had positive feedback from both the patients and therapists delivering this structured intervention.ConclusionImproved strategies are needed both in supporting inpatients to tolerate the group therapy setting and in helping them to develop the skills necessary for participation. Further larger‐scale research in this area is needed to consolidate these findings. Copyright © 2014 John Wiley & Sons, Ltd and Eating Disorders Association.
Flame retardants and heat release: review of data on individual polymers
Authors: Hirschler Marcelo M. 
Published: March 2014

SummaryThis work is the second of two parts that considered the following issue: do flame retardants affect heat release of polymers? The reason for investigating the issue is because it is important to assess whether the addition of flame retardants positively decreases fire hazard. This part of the work considered the two following issues. (1) Analysis of the individual polymeric materials that need to be studied. (2) Analysis of the data found on heat release (particularly peak heat release rate), ignitability (if available), and other thermal properties (as available) of polymers in small‐scale test data in recent years. The effects are being presented in terms of the percentage of improvement. The work demonstrated that, almost without exception, when adequately compounded systems were developed, the peak heat release rate of the flame retarded system was lower than that of the non‐flame retarded system. The overall conclusion of the two‐part study was that flame retardants does indeed improve fire safety (when used appropriately) and that a key reason for the beneficial effect of flame retardants is that they decrease heat release. Copyright © 2014 John Wiley & Sons, Ltd.
Selective Solid‐phase Extraction of Bisphenol A Using a Novel Stir Bar Based on Molecularly Imprinted Monolithic Material
Authors: Liu Kun‐Feng , Feng Rui , Zhang Yu‐Ping , Chen Jun , Bai Lian‐Yang 
Published: March 2014

AbstractIn this paper, a novel monolithic stir bar based on molecularly imprinted polymer (MIP) was firstly developed by filling modified neodymium magnet (Nd2Fe14B) powders into a glass tube (60 × 4 mm), followed by the imprinted grafting with bisphenol A (BPA) as the template molecule by thermal polymerization. It has been successfully used for the stir bar sorptive extraction (SBSE) and its extraction performance illustrated that the MIP‐encapsulated stir bar had stronger affinity to the template molecule, compared with the stir bar based on the non‐imprinted molecularly polymer (NIP). Under the optimal extraction conditions, a simple method based on the coupling of MIP‐SBSE with high performance liquid chromatography (HPLC) was used for the selective determination of the model mixtures of BPA, 4‐phenylphenol (PP) and phenol (P) in bottled water. The recoveries of BPA, PP and P were in the range of 88.5‐96.1%, 78.2‐89.7%, 81.3‐89.5% at three spiked levels, respectively, demonstrating that higher extraction and the specific absorption occurred between the template molecule and the prepared MIP stir bar.
A Convenient Preparation of Bis(4‐methoxyphenyl)methanethiol and Its Application in the Synthesis of Biotin Thioacid
Authors: Chou Tzyy‐Chao , Hsu Yu‐Ling , Lo Lee‐Chiang 
Published: March 2014

AbstractWe have established a facile protocol for the preparation of bis(4‐methoxyphenyl)methanethiol (4). Thiol 4 was used to prepare biotin thioester 7 which was later subjected to acidolysis to afford biotin thioacid (1b) in high yield. Compound 1b represents a new biotinylating reagent worth exploring and its spectral data was reported for the first time.
Baseline and new‐onset morphologic ECG abnormalities in healthy volunteers in phase I studies receiving placebo: Changes over a 6‐week follow‐up period
Authors: Hingorani Pooja , Karnad Dilip R. , Natekar Mili , Kothari Snehal , Narula Dhiraj 
Published: March 2014

AbstractMorphological ECG abnormalities occur in 5–12% healthy adults participating in early phase clinical trials. We retrospectively analyzed 16,472 12‐lead ECGs recorded at multiple time points in 420 volunteers (282 males, 138 females; aged 18–76 years) randomized to receive placebo from 19 Phase I studies to see if some baseline ECG abnormalities may disappear or new abnormalities may appear during the study. One hundred forty‐four (34.3%) subjects had abnormal baseline ECGs, of which 66 (44.8%) reverted to normal during follow‐up. Of 276 (65.7%) subjects with normal baseline ECGs, 118 (42.8%) developed ECG abnormalities over the next 6 weeks. Common baseline abnormalities included sinus bradycardia, R wave transition abnormalities, right axis deviation, non‐specific T wave changes and atrial premature complexes. On follow‐up ECGs, prolonged QT interval, first‐degree AV block, sinus bradycardia, short PR interval, and R wave transition abnormalities reverted to normal. Common new‐onset abnormalities in subjects with normal baseline ECGs included sinus bradycardia, prolonged QT interval, non‐specific T wave changes, R wave transition abnormalities, and sinus tachycardia. Thus, transient morphological ECG changes may occur in healthy volunteers possibly due to diurnal variation, effect of food, hormones, or autonomic changes. This should be considered when interpreting “treatment‐emergent” ECG changes in clinical trials.
Computational Search for Possible Mechanisms of 4‐Thiazolidinones Anticancer Activity: The Power of Visualization
Authors: Devinyak Oleg , Havrylyuk Dmytro , Zimenkovsky Borys , Lesyk Roman 
Published: March 2014

AbstractPublic databases of NCI‐60 tumor cell line screen results and measurements of molecular targets in the NCI‐60 panel give the opportunity to assign possible anticancer mechanism to compounds with positive outcome from antitumor assay. Here, the novel protocol of NCI databases mining where inferences are based on the visualization is presented and utilized with the aim to identify putative biological routes of 4‐thiazolidinones anticancer effect. As a result, highly potent 4‐thiazolidinone‐pyrazoline‐isatin conjugates show the similarity of activity patterns with puromycin and CBU‐028 and their pattern is also highly correlated with fraction of methylated CpG sites in CD34, AF5q31 and SYK. Several compounds from this group show strong negative correlation with fraction of methylated CpG sites in HOXA5. Thiopyrano[2,3‐d][1,3]thiazol‐2‐ones bearing naphtoquinone fragment were found to possess the same activity pattern as fusarubin does. But none of the studied 4‐thiazolidinone derivatives has activity fingerprint similar to standard anticancer agents. The obtained results bring medicinal chemistry closer to the understanding of basic nature of 4‐thiazolidinones effect on cancer cells.
The Development of Novel Chemical Fragment‐Based Descriptors Using Frequent Common Subgraph Mining Approach and Their Application in QSAR Modeling
Authors: Khashan Raed , Zheng Weifan , Tropsha Alexander 
Published: March 2014

AbstractWe present a novel approach to generating fragment‐based molecular descriptors. The molecules are represented by labeled undirected chemical graph. Fast Frequent Subgraph Mining (FFSM) is used to find chemical‐fragments (subgraphs) that occur in at least a subset of all molecules in a dataset. The collection of frequent subgraphs (FSG) forms a dataset‐specific descriptors whose values for each molecule are defined by the number of times each frequent fragment occurs in this molecule. We have employed the FSG descriptors to develop variable selection k Nearest Neighbor (kNN) QSAR models of several datasets with binary target property including Maximum Recommended Therapeutic Dose (MRTD), Salmonella Mutagenicity (Ames Genotoxicity), and P‐Glycoprotein (PGP) data. Each dataset was divided into training, test, and validation sets to establish the statistical figures of merit reflecting the model validated predictive power. The classification accuracies of models for both training and test sets for all datasets exceeded 75 %, and the accuracy for the external validation sets exceeded 72 %. The model accuracies were comparable or better than those reported earlier in the literature for the same datasets. Furthermore, the use of fragment‐based descriptors affords mechanistic interpretation of validated QSAR models in terms of essential chemical fragments responsible for the compounds’ target property.
Long‐time behavior of a nonlinear viscoelastic beam equation with past history
Authors: Narciso Vando 
Published: March 2014

AbstractThis paper is concerned with the existence of a global attractor for the nonlinear viscoelastic beam equation with past history memory
urn:x-wiley:1704214:media:mma3109:mma3109-math-0001where g(ut) is a damping like | ut | rut and f(u) is a source term like | u | αu − | u | βu, by considering 0 ≤ β < α and r > 0. Copyright © 2014 John Wiley & Sons, Ltd.
A method for testing accuracy of the calibration standards based on reciprocity conditions of the error network
Authors: Dahlberg Krista , Silvonen Kimmo , Kiuru Tero 
Published: March 2014

AbstractA method to define the accuracy of the known data of the calibration standards, presented in this article, is based on the reciprocity conditions of the error parameters. It can be seen that any error in calibration standards' definition leads to increasing apparent nonreciprocity in the error terms of passive test fixtures. It is an easy method to check the accuracy of the known data of the standards without any extra measurements or calculations. The method is demonstrated by simulations and wideband two‐tier on‐wafer measurements. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1036–1040, 2014
An all‐optical OCDMA encoder with simultaneous signal regeneration based on fiber four‐wave mixing
Authors: Galdino Lidia , Abbade Marcelo L. F. , Bonani L. H. , Marconi Jorge D. , Fragnito Hugo L. , Moschim Edson 
Published: March 2014

AbstractA new all‐optical optical code division multiple access encoder that simultaneously regenerates input signals is proposed and experimentally investigated. The device is based on a fiber four‐wave mixing and experimental results show that eye penalties may be decreased up to 5.1 dB. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1024–1028, 2014
Theoretical analysis of graphene nanoantennas with different shapes
Authors: da Costa Karlo Q. , Dmitriev Victor , Nascimento Clerisson M. , Silvano Gustavo L. 
Published: March 2014

AbstractIn this article, we present a numerical analysis of graphene nanoantennas with rectangular, elliptical, triangular, and circular geometries in terahertz band. We model the electromagnetic scattering of these planar structures by the method of moments with the surface impedance of graphene. We analyze the absorbing cross section and the resonances of nanoantennas for different, sizes, chemical potential, temperature, and incident angle. The obtained results can be useful to design efficient nanoantennas for terahertz wireless communications. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1019–1024, 2014
MIMO multiband antenna system combining resonant and nonresonant elements
Authors: Andújar Aurora , Anguera Jaume 
Published: March 2014

AbstractMulti‐input and multi‐output (MIMO) technology will enable high‐data rates in wireless devices to allow speech and video calls to streaming media and web browsing all over a common platform. MIMO technology needs M antennas both in transmission and reception. Because the space in a wireless device is limited, including M antennas is a challenge. To face such challenge, a MIMO antenna system is proposed, which comprises a multiband monopole antenna (35 × 15 mm2) and two small nonresonant elements, each one operating in a particular frequency region: 824–960 and 1710–2170 MHz. The size of each of the nonresonant elements is only 5 × 5 × 5 mm3. The proposed MIMO system is analyzed in terms of bandwidth, efficiency, correlation, and multiplexing efficiency. MIMO capacity is measured in a reverberation chamber considering a free‐space Rayleigh scenario and also including the effect of a phantom‐head and hand. The results reveal that the proposed MIMO system provides capacity close to the ideal bound, whereas having a small size and able to operate at several 2G, 3G, and 4G (long‐term evolution) standards. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1076–1084, 2014
Ultrawideband‐embedded multiband planar monopole antenna
Authors: Jung Pil Hyun , Kwak Jeong Seok , Lee Ha Eun , Yang Woon Geun 
Published: March 2014

ABSTRACTIn this letter, we present an ultrawideband (UWB)‐embedded multiband planar monopole antenna. The proposed antenna is composed of a chopped semicircular radiator appended with a meander and a folded branch microstrip line. Owing to inclusion of the semicircular radiator, the antenna can have the UWB characteristic. Also, the meander and the folded‐branch microstrip line guarantee low‐frequency bands, including global system for mobile communication, digital communication system, personal communications service (PCS), United States personal communications service (US‐PCS), wideband code division multiple access, bluetooth, and US‐worldwide interoperability for microwave access. A high‐frequency structure simulator was used to analyze the proposed antenna in the design process and to compare the simulation and experimental results. The bandwidth of the proposed antenna was measured for voltage standing wave ration less than 3. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1111–1115, 2014
Broadband T‐matching loop tag antenna design for on‐body UHF RFID applications
Authors: Chiu Chien‐Wen , Tsai Min‐Chuan , Wang Hwang‐Cheng , Wu Ter‐Feng 
Published: March 2014

ABSTRACTThis article proposes a printed loop tag antenna placed near a human body for use on student radio frequency identification cards. The proposed tag antenna printed on a polyvinylchloride card is a one‐wavelength loop fed by a T‐matching transformer. An equivalent lumped‐circuit for the T‐matching transformer is presented to synthesize the T‐matching feeding structure. A four‐layer stratified elliptical cylinder with physical parameters is utilized as a human model for EM simulations. The simulated bandwidth of the T‐matching loop tag antenna is 91 MHz (866–957 MHz, 10%). The T‐matching structure allows the loop antenna to have wideband characteristics. Experiments revealed that the reading distance ranges from about 3.3 to −6 m when the tag was placed in different positions on the human chest in the open space environment. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1194–1200, 2014
A reconfigurable printed dipole antenna using RF PIN diodes
Authors: Abbasiniazare Seyyedpayam , Manoochehri Omid , Forooraghi Keyvan 
Published: March 2014

AbstractA frequency switchable printed dipole antenna is proposed for multiband application. The electrical length of the dipole can be changed by controlling the pin diodes states so that the antenna can operate in three different frequency bands. The larger/smaller of the current path, the smaller/larger of the resonance frequency can be obtained. Three resonant frequencies from 200 to 1400 MHz are selected in this bandwidth and proper matching is achieved for all resonant frequencies. Also, a pair of capacitive stubs at the end of dipole have been used for achieving a resonant frequency lower than a standard dipole of comparable length. For optimizing the antenna structure, a parametric analysis has been performed by calculating the length and width of radiators with formulas. All simulated results have been confirmed with measured data. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1151–1155, 2014
A robust design of a numerically demanding compact rat‐race coupler
Authors: Kurgan Piotr , Bekasiewicz Adrian 
Published: March 2014

ABSTRACTA fast and accurate design procedure of a computationally expensive microwave circuit has been presented step‐by‐step and experimentally validated on the basis of a compact rat‐race coupler (RRC) comprising slow‐wave resonant structures. The final compact RRC solution has been obtained by means of a sequential optimization scheme exploiting the implicit space mapping algorithm. A well‐suited surrogate optimization starting point as well as a considerable limitation of the surrogate optimization variables contribute significantly to the numerical efficiency of the method proposed. The final design, offering 85% size reduction together with a satisfactory performance, has been obtained with only a handful of EM simulations. The experimental validation of the method has been successfully conducted. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1259–1263, 2014
Compact printed log‐periodic dipole antenna for water detection by using ground penetrating radar
Authors: Elsheakh Dalia M. , Abdallah Esmat A. 
Published: March 2014

ABSTRACTCompact printed fractal log‐periodic dipole antenna (FLPDA) is proposed for water detection using ground penetrating radar (GPR). First fractal structure is introduced in an antenna design and evolves the traditional Euclidean log‐periodic dipole array (LPDA). A fabricated proof‐of‐concept prototype of the proposed antenna is printed on a FR4 substrate with a relative permittivity of 4.7 on both substrate thickness 1.6 and 9.5 mm with occupied area of 85 × 110 and 60 × 70 cm2, respectively. The fabricated antenna has approximately 75% size reduction as compared to traditional LPDA. The −10dB impedance bandwidth extends from 45 MHz to more than 500 MHz. Both numerical and experimental results show that the FLPDA antenna has stable directional radiation patterns and apparently miniaturized effect, which are suitable for various ultrawideband applications. Main parameters and characteristics of the proposed antenna are discussed using both electromagnetic simulation and measurement. The effect of sandy soil, water layer, and the distance between sand and proposed antennas are also studied. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:1225–1232, 2014