bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison between the efficacy of cysteamine cream and combined hydroquinone cream in the treatment of melasma using skin analytical systems: An open-label quasi-randomized controlled trial in Asia patients
Authors: Chuang Andy Deng-Chi , Lin Erh-Ti , Chang Chang-Cheng , Huang Yung-Hsueh , Lu Meng-En , Chuang Chun-Fang , Chiang Hsiu-Mei 
Published: August 2024

Abstract

Background:
The mainstay of treatment for melasma is topical hydroquinone or preparations containing hydroquinone. In recent years, cysteamine cream has gained popularity in the treatment of hyperpigmentation disorders.

Objectives:
This study aimed to compare the efficacy of combined hydroquinone/betamethasone to cysteamine in the treatment of melasma.

Methods:
Eighteen patients had completed this open-label controlled trial. Subjects received either 5% cysteamine cream or a combination of 4% hydroquinone cream and 0.06% betamethasone valerate for 12 weeks according to standardized protocols. Patients were assessed at recruitment, 4 weeks, and 12 weeks after treatment for Melasma Area and Severity Index (MASI) scores. Other parameters relating to skin complexions and patient satisfaction were also assessed.

Results:
Patients treated with hydroquinone (n = 7) and cysteamine (n = 11) both showed significant decreases in MASI score at week 12: 33.1% (P = 0.009) and 37.9% (P = 0.009), respectively. There was no statistically significant difference between the two treatment groups (P = 0.236). Melanin content at week 12 decreased by 8.8% (P = 0.016) in the hydroquinone group and 11.5% (P = 0.046) in the cysteamine group, with no significant difference between the groups (P = 0.253). No significant differences were observed between the groups for other parameters or patient satisfaction.

Conclusion:
Cysteamine cream may provide an alternative treatment option for individuals with melasma, offering fewer side effects while delivering comparable results.
Long-term outcome in patients who underwent total laparoscopic hysterectomy with preservation of pericervical ring: An institutional-based descriptive study
Authors: Agarwal Mukta , Sinha Shivangni , Barmade Kalyan B. , Singh Shruti , Haripriya H. 
Published: August 2024

Abstract

Background:
Surgery for pelvic organ prolapse requires a thorough knowledge and understanding of the anatomy in order to restore function and alleviate symptoms. It is important to maintain the integrity of vaginal supports to prevent long-term postoperative sequelae. The aim was to study pelvic organ prolapse and sexual dysfunction in patients following total laparoscopic hysterectomy (TLH).

Materials and Methods:
A retrospective descriptive study was conducted in a tertiary care center from June 2016 to October 2022. Three hundred and forty-four patients were included in the study. It included all patients who had undergone TLH.

Results:
None of them had pelvic organ prolapse. The study also showed insignificant sexual dysfunction. The longest time of follow-up done from the day of surgery to evaluation for prolapse/sexual function in our study was seen to be 6.2 years, with the shortest follow-up time at 3 months.

Conclusion:
Based on the results of the present study, preservation of the pericervical ring and suspension of the vaginal vault as near as possible to its anatomical position seems an effective intervention to prevent long-term morbidity in patients.
Rehabilitation Protocol for Children with Chest Tube for Pleural Effusion: A Quasi-Experimental Pre- and Post-test Study
Authors: Kumar Sanyal , Kumar Anjani , Pandey Sanjay Kumar 
Published: August 2024

Abstract

Objective:
The objective is to evaluate the effectiveness of a structured rehabilitation protocol on respiratory function and overall recovery in children with chest tubes for pleural effusion.

Materials and Methods:
A quasi-experimental pre-test and post-test design was employed. Thirty children aged 5–12 years with chest tubes for pleural effusion were enrolled. Participants were assessed before and after the intervention using pulmonary function tests (PFTs), physical activity levels and quality of life (QoL) surveys. The rehabilitation protocol included breathing exercises, physical therapy and educational sessions for patients and caregivers.

Results:
Significant improvements were observed in PFTs, physical activity levels and QoL scores post-intervention (P < 0.05).

Conclusion:
The structured rehabilitation protocol was effective in enhancing respiratory function and overall recovery in paediatric patients with chest tubes for pleural effusion.
Prevalence of internet addiction and its association with quality of sleep among secondary and higher secondary school students of Jamnagar Gujarat during COVID-19
Authors: Patel Niraj P. , Garg Anusha S. , Tiwari Deepak S. , Shah Viral R. 
Published: August 2024

Background:
The internet is a vital part of present-day society. Internet use for education has increased in recent years. During the COVID pandemic, schools were closed and education was delivered through online methods, which led to a further increase in internet use, especially in adolescents, leading to internet addiction in some.

Aim:
To estimate the prevalence of internet addiction and poor quality of sleep in adolescent students of Jamnagar.

Materials and Methods:
This cross-sectional study was carried out between January 2022 to March 2022 and included 1778 adolescent students of Jamnagar, Gujarat. The internet addiction test was used to measure the level of internet addiction, and the short Pittsburgh sleep quality index was used to measure the quality of sleep. Data analysis was conducted using the Chi-square test, Mann-Whitney U test, and multiple logistic regression techniques.

Results:
In our study, 17.8% of participants had mild internet addiction, 3.2% of participants had moderate-to-severe internet addiction, and 79% of participants were average internet users. Associated variables with internet addiction were male gender, residence at home, duration of internet usage in years, daily hours spent online, and monthly expenditure on internet recharge. Furthermore, 27.2% of participants had poor quality of sleep. Female gender, secondary school education, residence at the hostel, and internet addiction were predictors of poor quality of sleep.

Conclusion:
Students were found to have a high prevalence of internet addiction. The internet usage increased amid the COVID-19 pandemic. Internet addiction was significantly associated with poor quality of sleep in adolescents.
Autistic features in patients with intellectual disability attending the psychiatry outpatient department of a tertiary healthcare center
Authors: Akash Nema , Santre Manjeet , Panse Smita , Madhur Rathi , Sonawane Kranti 
Published: August 2024

Background:
Meta-syndromic groups with cognitive and relational impairment include both autism spectrum disorder (ASD) and intellectual disability (ID). When it comes to individuals with intellectual difficulties, autistic traits are often unexplored unless they reach the level of the syndrome. The presence of both autism and ID increases disability percentage.

Aim:
To study the presence of autistic symptoms in individuals with ID.

Materials and Methods:
This was a cross-sectional, observational study in which after informed consent from caretakers of patients with ID, clinical history and sociodemographic details were recorded. Further Indian Scale for Assessment of Autism (ISAA) was administered for evaluation of autistic features. Statistical analysis of the data was done using the Chi-square test and Spearman’s correlation.

Results:
Out of 150 subjects with ID, 18% (n = 27) were diagnosed with comorbid ASD. A statistically significant (P value = <0.001) association was found between the severity of ID (intelligence quotient, [IQ]) and the severity of autism in patients. Various domains of autism like social relation and reciprocity, speech, language, communication, emotional responsiveness, etc., showed a statistically significant correlation with IQ.

Conclusion:
This study finding also highlights that lower IQ scores, i.e., severe ID have higher incidence and severity of autistic features. Improving assessment both clinically and on objective testing can help in planning rehabilitation for these patients.
Time for tough conversations: Ableism in the life journey of young adults with visual impairment
Authors: Yovan Joice Steffi , Majhi Gobinda , Janardhana Navaneetham 
Published: August 2024

Background:
Visual impairment (VI) profoundly impacts many aspects of life and is well documented in various cross-sectional studies. Young people’s views on growing up with VI are largely unexplored in the Indian context.

Aim:
This study explores a critical concept called “ableism” as they navigate through childhood and adolescence.

Materials and Methods:
The study used an exploratory research design, with QUAL+ QUAN methodology, where the data collection occurred almost simultaneously, and the qualitative was the dominant method. For the quantitative data collection
, seventy youth with visual impairment aged 18-25 years were recruited through convenient and snowball sampling. For the qualitative data collection, 20 were selected based on purposive sampling. Kessler Psychological Distress Scale (K10) was used with 70 participants as part of quantitative data collection. An empirically based interview guide encouraged participants’ reflection on growing up with VI, including the internal and external age-normative and vision-specific challenges. The interviews were analyzed using thematic analysis.

Results:
Thirty percent of the participants reported psychological distress at varying levels from mild to severe. The account of growing up with VI also centered on a theme labeled “ableism.” Six subthemes representing “ableism” are 1) invasion or avoidance, 2) you achieve, and I will respect, 3) disgraceful experiences, 4) you are our inspirational meme, 5) double vulnerability, and 6) internalized ableism. Each subtheme discusses different forms of ableism experienced by young people with VI.

Conclusion:
Findings are discussed in relation to the limiting attitude and structure of the society that affects the lives of young people with VI. They highlight the need to understand the nuances of ableism which helps to revisit and reflect as a society.
Assessment of Left Ventricular Reverse Remodeling by Echocardiography After 90 Days of Sacubitril/Valsartan Therapy in Patients of Heart Failure with Reduced Ejection Fraction
Authors: Pawar Akshay , Rajani Rajesh , Phalgune Deepak Sadashiv 
Published: August 2024

Abstract

Background:
The present study aimed to assess the response of sacubitril/valsartan therapy on cardiac reverse remodeling (CRR) by standard and advanced echocardiographic parameters in patients of heart failure with reduced ejection fraction (HFrEF).

Methods:
One hundred and fifty patients ≥18 years of age with symptomatic heart failure with left ventricular ejection fraction (LVEF) <40.0% were included in this prospective observational study. All patients underwent baseline electrocardiography and standard echocardiographic examination. Patients were given sacubitril/valsartan maximal tolerated dose. Echocardiographic measurements were done after 90 days. The primary outcome measure was a change in LVEF, whereas the secondary outcome measures were changes in left ventricular dimensions and volumes, E/e’, pulmonary artery systolic pressure (PASP), and global longitudinal strain (GLS). Comparisons between two discrete variables and medians were performed using the Chi-square test/Fisher’s exact test and the Wilcoxon signed–rank test, respectively.

Results:
The median LVEF (32.5% vs. 30.0%) was significantly higher, whereas left ventricular end-diastolic volume (180 vs. 177.5 mL), left ventricular end-systolic volume (127.5 vs. 122.5 mL), left ventricular end-diastolic diameter (59 vs. 58 mm), left ventricular end-systolic diameter (51 vs. 50 mm), PASP (38 vs. 35), E/e’ (15 vs. 14), and GLS (−9.0 vs. −10.0) were significantly lower at 3-month follow-up as compared to baseline levels. Sacubitril/valsartan therapy leads to CRR as early as 90 days in patients with HFrEF.

Conclusions:
In HFrEF patients, sacubitril/valsartan significantly improved CRR.
Bone marrow-derived mesenchymal stem cell-derived exosome-loaded miR-129-5p targets high-mobility group box 1 attenuates neurological-impairment after diabetic cerebral hemorrhage
Authors: Wang Yue-Ying , Li Ke , Wang Jia-Jun , Hua Wei , Liu Qi , Sun Yu-Lan , Qi Ji-Ping , Song Yue-Jia 
Published: August 2024

BACKGROUND
Diabetic intracerebral hemorrhage (ICH) is a serious complication of diabetes. The role and mechanism of bone marrow mesenchymal stem cell (BMSC)-derived exosomes (BMSC-exo) in neuroinflammation post-ICH in patients with diabetes are unknown. In this study, we investigated the regulation of BMSC-exo on hyperglycemia-induced neuroinflammation.
AIM
To study the mechanism of BMSC-exo on nerve function damage after diabetes complicated with cerebral hemorrhage.
METHODS
BMSC-exo were isolated from mouse BMSC media. This was followed by transfection with microRNA-129-5p (miR-129-5p). BMSC-exo or miR-129-5p-overexpressing BMSC-exo were intravitreally injected into a diabetes mouse model with ICH for in vivo analyses and were cocultured with high glucose-affected BV2 cells for in vitro analyses. The dual luciferase test and RNA immunoprecipitation test verified the targeted binding relationship between miR-129-5p and high-mobility group box 1 (HMGB1). Quantitative polymerase chain reaction, western blotting, and enzyme-linked immunosorbent assay were conducted to assess the levels of some inflammation factors, such as HMGB1, interleukin 6, interleukin 1β, toll-like receptor 4, and tumor necrosis factor α. Brain water content, neural function deficit score, and Evans blue were used to measure the neural function of mice.
RESULTS
Our findings indicated that BMSC-exo can promote neuroinflammation and functional recovery. MicroRNA chip analysis of BMSC-exo identified miR-129-5p as the specific microRNA with a protective role in neuroinflammation. Overexpression of miR-129-5p in BMSC-exo reduced the inflammatory response and neurological impairment in comorbid diabetes and ICH cases. Furthermore, we found that miR-129-5p had a targeted binding relationship with HMGB1 mRNA.
CONCLUSION
We demonstrated that BMSC-exo can reduce the inflammatory response after ICH with diabetes, thereby improving the neurological function of the brain.
Design, Fabrication and Performance Evaluation of Teff Cleaning Machine
Authors: BELETE ZABLON ZELEKE 
Published: August 2024

In this study, the teff (Eragrostis tef) cleaning machine was designed, constructed, and tested. The cleaner works by the principle of air-screen cleaning, which uses a fan system to remove lightweight materials and a mechanical system to remove materials with larger sizes. The machine consists of a feeding, separating and cleaning units, and power transmission components such as shafts, belts, pulleys, and bearings. The materials used for fabrication were based on the physical and mechanical properties of teff seed, design considerations like cost and availability of materials, and design analysis of machine components. The preliminary test of the machine with three feed rate and three sieve inclinations showed that the cleaning efficiency decreased from 88.72% to 69.35% for 0-degree sieve inclination, 97.85% to 73.67% for 5-degree sieve inclination, and 83.15% to 52.02% for 10-degree sieve inclination when feed rate increased from 5 kg/min to 15 kg/min respectively and the cleaning loss increased from 5.23% to 10.05% for 0-degree sieve inclination, 0.87% to 4.37% for 5-degree sieve inclination and 10.17% to 25.70% for 10-degree sieve inclination when feed rate increased from 5 kg/min to 15 kg/min respectively. The result showed that for increased feed rate, the cleaning efficiency decreased and cleaning loss increased in general.
MAGNETIC CONTROL OF A HARD DRIVE'S INTERNAL MILLIMETER-SIZED BEAM
Authors: RACHID KHELFAOUI 
Published: August 2024

This research making after critical review pf ontrol actuator devices and modelling milimetric arm cantilver analytical behavior. An experiment designed to learn more about how an actuator put in a laptop hard drive operates. A appropriate coil, likewise driven by a DC/DC converter, influences and exerts force on the actuator's actuation. The acquired response is impacted by interference induced by room illumination, and the findings demonstrate that the micrometric arm is considerably influenced by the action of the converter. However, the data acquired permits us to suggest this instrument for microfluidic uses.
INTERACTIVE FEFFECT OF LIGHT INTENSITY AND HYDRO- AND HALO PRIMING, USING SOME K- AND Mg-SALTS, ON FLORAL ATTRIBUTES AND PRODUCTIVITY OF TWO GENOTYPES OF WHEAT (Triticum aestivum L.)
Authors: Khatoon Sanjeeda , Singh Amar 
Published: August 2024

Seed priming cause invigoration of seeds in this process the seed grains are allowed to soak moisture till a period before protrusion of radicle (safe limit). When soaking medium is water it is called hydropriming and when salt solutions is used it called halopriming. In priming, the seeds are dried back to original moisture content after soaking till safe limit. In present study, a comparative study on the effect of interaction of hydro- and halo-priming on two genotypes (WR-544 and DBW-187) of wheat were studied for impact on floral attributes and productivity. Distilled water was used for hydro-priming and 0.5, 1.0 and 1.5% of KCl, KH2PO4, Mg(NO3)2 and MgSO4 salt solutions were used for hydro priming. The study revealed that floralinitiation took in just 43 days in ‘WR 544’ under 1.5% Mg(NO3)2 + 100% light treatment and 1.5% MgSO4 + 50% light treatment; whereas it took place in 60 days under 1.0% KH2PO4 + 50% light treatment. In genotype ‘DBW-187’, flowering took place in 56 days under hydro-priming + 100% light as well as 50% light interacted with hydro-priming or halo-priming with 0.5% KCl. In genotype ‘WR-544’ the viable grains in 1.5% Mg(NO3)2 + 100% light treatment were 377. In both genotypes halo-priming improved productivity. In genotype WR-544, 388 spikelets were produced under 100% light + 1.5% Mg(NO3)2 treatment. The genotype WR-544 appeared better performer than DBW-187 under both priming conditions.
DETERMINATION OF ANTIFUNGAL AND ANTIOXIDANT POTENTIAL OF LEAF AND FRUIT EXTRACTS OF GUAVA (Psidium guajava Linn.)
Authors: Bhardwaj Richa , Naruka Devyani , Purohit Smita 
Published: August 2024

The present study was aimed to evaluate the antifungal and antioxidant properties of leaf and fruit extracts of guava (Psidium guajava Linn.). Antifungal assays were conducted to assess the efficacy of extracts against clinically relevant fungal strains, viz., Aspergillus niger MTCC-4325, Penicillium chrysogenum MTCC-2539, Candida albicans MTCC-7315, and Fusarium solani MTCC-3309. Besides, enzyme activity for catalase (CAT) and peroxidase (POD) were assayed to elucidate the antioxidant potential of extracts. The radical scavenging activities of extracts were determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH), and ferric reducing antioxidant power (FRAP) assays to quantify the overall antioxidant capacity. Results indicated pronounced inhibitory activity against F. solani in methanolic extracts of leaves (21.66 ± 2.05) and fruits (24.66 ± 1.25), with aqueous extracts exhibiting comparatively lesser inhibition across the tested fungal strains. Moreover, the enzyme activity assays revealed higher CAT and POD activities in fresh leaf extract as compared to the fruit extract. Notably, DPPH assay underscored the superior antioxidant potential of Psidium leaf extracts relative to fruit extracts, while FRAP assay showed higher radical scavenging capacity of methanolic extract as compared to the aqueous extract.
CYTOTOXIC EFFECT OF Brassica oleracea L. var. italica FLORETS AND MICROGREENS ON ACUTE LEUKEMIC CANCER CELL LINE
Authors: Shah Ami , Gadhvi Rekha 
Published: August 2024

The bioactivity of broccoli microgreens might be valuable for understanding the association between diet and cancer along with searching for healthy and functional food options. The present study was centred on broccoli microgreens as a functional food. The anticancer activity was measured in broccoli florets and microgreens. The cytotoxicity of microgreens extract was confirmed by flow cytometry assays. Significantly higher anticancer activity was observed in microgreens as compared to the florets. The IC50 value for Thp-1 cell line was 772.47 and 446.34 µg mL-1for florets and microgreens, respectively. In cell cycle analysis, 69% cells were arrested at G0/G1 phase. The 8.58% of dead cells were detected in early apoptosis. As the cells were in early apoptosis, DNA damage was observed only in 3.53% cells. Thus, the increased consumption of broccoli microgreens could have significantly positive impact on human health.
ASYMBIOTIC SEED GERMINATION OF AN ANTICANCEROUS TERRESTRIAL ORCHID Eulophia nuda Lindl. AND ITS ADULTERANT Geodorum densiflorum (Lam) Schltr.
Authors: Thakur Uma , Dongarwar Nitin 
Published: August 2024

Eulophia nuda Lindl. corms are used to cure cancer and is overexploited by the traditional medicine practitioners and medicinal plant traders. The corms of Geodorum densiflorum look morphologically similar to the corms of Eulophia nuda, hence it is used as an adulterant to the corms of Eulophia nuda, consequetly, the population of G. densiflorum is also facing the exploitation pressure. In present study, asymbiotic seed germination of both the terrestrial orchids was achieved using six media like Vacin and Went (WV) medium, Malmgren modified (MM) terrestrial orchid medium, modified Kundson C medium, ½ MS medium, Lindemann medium (LM) and BM1 medium along with three photoperiods (0/24, 16/8, and 24/0 h L/D). Eulophia nuda showed highest asymbiotic seed germination on MM medium (80.55 %) and the best light treatment was 0/24 h L/D. The highest asymbiotic seed germination of G densiflorum was on VW (84.07%), LM (83.29%) and BM 1(81.02%) and the best light treatment was 24/0 h L/D.
Analisis Tingkat Kesadaran Keamanan Cyber di Media Sosial Instagram: Studi Kasus pada Siswa SMK Negeri 1 Banyudono
Authors: Mahendra Abrar Farizi , Hatta Puspanda , Aristyagama Yusfia Hafid 
Published: August 2024

Penelitian ini memiliki tujuan untuk, mengetahui tingkat kesadaran siswa dalam menggunakan Instagram terkait keamanan siber di SMK Negeri 1 Banyudono, dan mengidentifikasi faktor-faktor yang memengaruhi tingkat kesadaran tersebut. Menggunakan metode kuantitatif, penelitian ini melibatkan 1062 pelajar dari tingkat X, XI, dan XII sampel 300 siswa yang dipilih secara acak. Pengumpulan data dilakukan dengan menggunakan kuesioner Google Form dan dianalisis menggunakan analisis deskriptif serta analisis regresi linear berganda menggunakan Microsoft Excel dan IBM SPSS versi 22. Temuan penelitian mengungkapkan bahwa 62.3% siswa memiliki kesadaran keamanan tinggi, 36.7% sedang, dan 1.0% rendah. Faktor usia, jurusan, dan kelas mempengaruhi tingkat kesadaran secara signifikan, sedangkan gender tidak.