bluuebunny/crossref_metadata_2025_split huggingface dataset:
Epigenetically modulated LRRC33 acts as a negative physiological regulator for multiple Toll-like receptors
Authors: Su Xiaomin , Mei Shiyue , Liang Xue , Wang Shihua , Liu Jingyi , Zhang Yuan , Bao Yue , Chen Yanan , Che Yongzhe , Chunhua Zhao Robert , Zhang Zhujun , Yang Rongcun 
Published: February 2014

ABSTRACTThe members of a LRR family play crucial roles in the activation of innate and adaptive immune responses. We reported previously that LRRC33, a transmembrane protein of the LRR family, might potentially affect TLR-mediated activity. Here, we demonstrate that LRRC33 is a negative physiological regulator for multiple TLRs. Lrrc33−/− and Lrrc33+/− mice were more susceptible to TLR ligand challenges. The macrophages and DCs from Lrrc33−/− mice produced more proinflammatory cytokines than those of WT mice through increased activation of MAPK and NF-κB. Silencing LRRC33 also promoted multiple TLR-mediated activation in human moDCs. Notably, LRRC33 expression could be down-regulated by TLR ligands LPS, poly I:C, or PGN through H3K4me3 and H3K27me3 modification. In LPS-conditioned moDCs, reduced enrichment of H3K4me3 and increased H3K27me3 could be observed at the promoter region of LRRC33. Furthermore, silencing H3K4me3-associated factors MLL and RBBP5 not only decreased the enrichment of H3K4me3 but also down-regulated expression of LRRC33, whereas the expression of LRRC33 was up-regulated after silencing H3K27me3-associated factors EZH2 and EED. Thus, our results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis.
Vitamin D3 and phenylbutyrate promote development of a human dendritic cell subset displaying enhanced antimicrobial properties
Authors: van der Does Anne M , Kenne Ellinor , Koppelaar Ella , Agerberth Birgitta , Lindbom Lennart 
Published: February 2014

AbstractA promising strategy in the fight against multidrug-resistant pathogens is the induction of endogenous AMPs, with compounds such as VitD3 and PBA. These compounds display an array of immunomodulatory effects that remain to be investigated in further detail to establish their role in the clearance of infection and possible modulation of AMP expression. Here, we have investigated the effects of VitD3 and PBA on human monocyte-DC differentiation and found that VitD3 and PBA promote the development of a stretched CD14+/CD1a− DC subset. This subset produced enhanced levels of ROS and human cathelicidin; furthermore, it displayed enhanced killing capacity of Staphylococcus aureus compared with control DCs. When experiments were performed in WT and cathelicidin-deficient mice, we established that a ROS-producing, stretched DC subset was also induced in mouse-derived cells, independent of cathelicidin expression. However, in contrast to the human DCs, enhanced cathelicidin expression and enhanced antimicrobial activities were not found in the murine VitD3/PBA DC subset. In conclusion, the results of this study show that VitD3 and PBA induce a human DC subset that is effective against infection. These results promote further research into the use of these compounds as an antimicrobial treatment strategy.
Use of Auxiliary Functions in Evaluation of Self-Frictional Overlap Integrals over Noninteger n Slater Type Orbitals
Authors: Guseinov Israfil I , Mamedov Bahtiyar A 
Published: February 2014

Abstract
By the use of auxiliary functions with the noninteger indices introduced by one of the authors, the formulas for the S(α*)-self-frictional overlap integrals (S(α*)-SFOIs) of χ-Slater type orbitals with noninteger principal quantum number (χ-NISTOs) are presented, where α* is the self-frictional quantum number. The suggested approach guarantees a highly accurate calculation of the S(α*)-SFOIs for the arbitrary values of parameters and locations of orbitals.
Social Fire Risk Calculation in Respect to Gas Transportation Facilities
Authors: Быков  , Bykov A. 
Published: February 2014

Approaches to definition of social risk indicators in current regulations applicable to gas transportation facilities are
analyzed. It has been shown that these indicators’ evaluation should be undertaken within a framework of fire and accident
risks, i.e. objects operate on combustible gas moving under overpressure. It is specified that existing techniques doesn´t
contain a concept of social fire risk in general. The remaining existing regulations are not applied to social risk value
assessment at gas transmission facilities.
Inclusive Leisure and Individuals With Intellectual Disability
Authors: Dattilo John 
Published: February 2014

AbstractThis article contains information about issues associated with the inclusion of people with intellectual disability and their participation in leisure within their communities. Concepts identified are intended to create dialogue about the provision of supports, establishment of policies, and implementation of research associated with inclusive leisure opportunities and people with intellectual disability. To begin this dialogue, the relevance of leisure is described to establish a foundation of understanding about inclusion, leisure, and people with intellectual disability. This is followed by identification of some major issues and techniques that may be helpful to reflect on when providing leisure supports and establishing policies. The final section of the paper contains considerations that may be useful when attempting to conduct research that is respectful and meaningful to people with intellectual disability, their families and friends, human service providers, and other members of the community.
Trust, Truth, Status and Identity: An Experimental Inquiry
Authors: Butler Jeffrey V. 
Published: February 2014

AbstractTo investigate how group-contingent non-pecuniary preferences are affected when one group occupies a position of higher status than another group, experimental participants were divided into two trivially distinct groups and then one of the groups was randomly assigned “high status.” Control sessions were also conducted in which no status distinction was introduced. In all sessions, participants subsequently played two games governed by distinct social norms: a trust game and a cheap talk game where lying was possible. In the control sessions, norm compliance was higher in same-group interactions, consistent with previous research demonstrating that normative obligations are often parochial. In treatment sessions, parochialism vanished and was replaced by noblesse oblige: members of high status groups exhibited more norm compliance in all of their interactions. Finally, in game roles not governed by an unambiguous social norm, identity had no direct impact on behavior. Considered together, the results suggest that the channel through which social identity directly impacts behavior is norm compliance and that the nature of this impact depends crucially on the relationship between involved groups.
Severe Bacillus cereus infection in a neonatal intensive care unit
Authors: Machado Clara , Silva Albina , Magalhães Maria J. , Sá Carla , Abreu Eduarda , Matos António M. , Pereira Almerinda 
Published: February 2014

Abstract
Infections of the central nervous system (CNS) in neonates with very low birth weight (VLBW) may have major clinical consequences due to their immunocompromised status. Bacillus cereus is a rare pathogen that can cause serious infection in these patients and is associated with a high mortality rate. We report the case of an extremely preterm neonate who developed severe infection of the CNS caused by B. cereus with progressive neurological deterioration despite broad spectrum antibiotic treatment. She died at the age of 16 months. In conclusion, we wish to increase the awareness among health care practitioner about the possibility of infection due to B. cereus in sick neonates and its devastating course in this population.
A note for alternating Ramanujan's circular summation formula
Authors: Liu Xian-Fang , Luo Qiu-Ming 
Published: February 2014

Abstract
Recently, Zhu gave an alternating circular summation
of theta functions (see [Appl. Anal. Discrete Math. 6 (2012), 114–125]). In this paper, we further extend Zhu's results. Some applications are also shown.
A note about complexity of lens spaces
Authors: Casali Maria Rita , Cristofori Paola 
Published: February 2014

Abstract
Within crystallization theory, (Matveev's) complexity of a 3-manifold can be estimated by means of the combinatorial notion of GM-complexity.
In this paper, we prove that the GM-complexity of any lens space

L
(
p
,
q
)

${L(p,q)}$

, with p ≥ 3, is bounded by

S
(
p
,
q
)
-
3

${S(p,q) -3}$

, where

S
(
p
,
q
)

${S(p,q)}$

denotes the sum of all partial quotients in the expansion of

q
p

${\frac{q}{p}}$

as a regular continued fraction. The above upper bound had been already established with regard to complexity; its sharpness was conjectured by Matveev
himself and has recently been proved for some
infinite families of lens spaces by Jaco, Rubinstein and Tillmann.
As a consequence, infinite classes of 3-manifolds turn out to exist, where complexity and GM-complexity coincide.
Moreover, we present and briefly analyze results arising from
crystallization catalogues up to order 32, which prompt us to
conjecture, for any lens space

L
(
p
,
q
)

${L(p,q)}$

with p ≥ 3, the
following relation:

k
(
L
(
p
,
q
)
)
=
5
+
2
c
(
L
(
p
,
q
)
)

${k(L(p,q)) = 5 + 2 c(L(p,q))}$

, where c(M)
denotes the complexity of a 3-manifold M and

k
(
M
)
+
1

${k(M) +1}$

is half the minimum order of a crystallization of M.
Fractional type Marcinkiewicz integral operators on function spaces
Authors: Xue Qingying , Yabuta Kôzô , Yan Jingquan 
Published: February 2014

Abstract
In this paper, we discussed about the boundedness of the
fractional type Marcinkiewicz integral operators, and improved a result given
by Chen, Fan and Ying in 2002. They showed that
under certain conditions the fractional type Marcinkiewicz integral operators
are bounded from the Triebel–Lizorkin spaces

F
˙

p
q

α

(

ℝ
n

)

${\dot{F}_{pq}^{\alpha }({\mathbb {R}^n})}$

to

L
p

(

ℝ
n

)

${L^p({\mathbb {R}^n})}$

. We greatly weakened their assumptions and extended their results
to a pretty much more general way.
Characteristics of the Bending Moment Acting on an Overhung Shaft in a Stirred Vessel
Authors: Shi Daien , Lu Tao , Eaglesham Archie , Gao Zhengming 
Published: February 2014

Abstract
The bending moment acting on an overhung shaft in an impeller stirred vessel was measured using a moment sensor equipped with digital telemetry. The results show that the characteristics of bending moment, such as the mean amplitudes, the amplitude and frequency distributions and the intensity of the amplitude fluctuations are influenced by both the ratio of operational speed to resonant speed (n/nr) and the impeller type. Analysis of the bending moment amplitude shows that the dimensionless shaft bending moment decreases for low values of n/nr and increases with increasing n/nr for higher values of n/nr. The value of the n/nr transition point depends on the type of impeller used in the experiments. Analysis of the power spectral density of bending moment fluctuation shows that the main contributions to the bending moment for low impeller speeds (i.e. well below the first resonant frequency) come from factors related to the fluid flow while the impeller imbalance becomes steadily more dominant as the speed increases.
Effects of Moisture Content and Impact Energy on the Cracking Characteristics of Walnuts
Authors: Shahbazi Feizollah 
Published: February 2014

Abstract
A study was conducted to determine the effects of moisture content and energy of impact on the cracking characteristics of walnuts. A sample of fresh harvested walnuts was divided into four portions and conditioned under sunshine for different time durations to obtain different levels of moisture content [9.2–29.7%, wet basis (w.b.)]. An impact test apparatus was used to apply different impact energies in the range of 0.13–1.11 J to samples with different moisture content. Data obtained on the quantity of fully cracked and unbroken kernel, fully cracked but broken kernel and uncracked nuts were used in the computation of the nuts cracking characteristics. Results showed that moisture content, impact energy and interaction effects of these two variables have significant effect on the walnuts cracking characteristics. Full cracking of nuts increased with impact energy and decreasing moisture content. The optimum moisture content for cracking walnuts that gave the best result combination of high whole kernel yield and low kernel breakage was found to be about 16%. The optimum impact energy for cracking was found to be about 1.01 J (1.01 ± 0.1 J). The results of this study show that development of a centrifugal impact cracker, which uses impact to crack walnuts, is possible. In the designing of the walnut cracker, the radius and speed of the cracker should be such that create impact energy and velocity of about 1.01 J and 11 m/s, respectively, and walnuts should be conditioned to the moisture content of about 16% for optimum efficiency.
Health hazards and mitigation of chronic poisoning from arsenic in drinking water: Taiwan experiences
Authors: Chen Chien-Jen 
Published: February 2014

Abstract
There are two endemic areas of long-term exposure to arsenic from drinking water in Taiwan. Residents in the southwestern and northeastern endemic areas started using high-arsenic artesian well water in the early 1910s and late 1940s, respectively. Public water supply system using surface water was implemented in southwestern and northeastern endemic areas in the 1970s and 1990s, respectively. Systemic health hazards of long-term exposure to arsenic in drinking water have been intensively investigated since the 1960s, especially after 1985 in Taiwan. Several diseases have been well documented to be associated with chronic arsenic poisoning from drinking water showing a dose-response relation. They include characteristic skin lesions like hyperpigmentation or depigmentation, hyperkeratosis in palms and soles, and Bowen disease, peripheral vascular disease (specifically blackfoot disease), ischemic heart disease, cerebral infarction, microvascular diseases, abnormal peripheral microcirculation, carotid atherosclerosis, QT prolongation and increased dispersion in electrocardiography, hypertension, goiter, diabetes mellitus, cataract (specifically posterior subcapsular lens opacity), pterygium, slow neural conduction, retarded neurobehavioral development, erectile dysfunction, and cancers of the skin, lung, urinary bladder, kidney, and liver. The method of choice to mitigate arsenic poisoning through drinking water is to use safe drinking water from uncontaminated sources.
Changes in Cerebral CB1Receptor Availability after Acute and Chronic Alcohol Abuse and Monitored Abstinence
Authors: Ceccarini Jenny , Hompes Titia , Verhaeghen Anne , Casteels Cindy , Peuskens Hendrik , Bormans Guy , Claes Stephan , Van Laere Koen 
Published: February 2014

Involvement of the type 1 cannabinoid receptor (CB1R) in the effects of alcohol on the brain is supported by animal experiments, but howin vivoCB1R levels are altered in alcoholic patients is still unclear. To assess the short-time effects of a binge drinking episode on CB1R availability, 20 healthy social drinkers underwent [18F]MK-9470-positron emission tomography (PET) at baseline and after intravenous ethanol administration (ALC ACU). Moreover, 26 alcoholic patients underwent sequential CB1R PET after chronic heavy drinking (ALC CHR) and after 1 month of abstinence (ALC ABST). Seventeen healthy subjects served as controls.Compared with baseline, ALC ACU resulted in a global increase of CB1R availability (+15.8%). In contrast, a global decreased CB1R availability was found in ALC CHR patients (−16.1%) compared with controls, which remained unaltered after abstinence (−17.0%). Voxel-based analysis showed that ALC CHR patients had reduced CB1R availability, especially in the cerebellum and parieto-occipital cortex. After abstinence, reduced CB1R availability extended also to other areas such as the ventral striatum and mesotemporal lobe.In conclusion, whereas the acute alcohol effect is an increase in CB1R availability, chronic heavy drinking leads to reduced CB1R availability that is not reversible after 1 month of abstinence. Longer follow-up is required to differentiate whether this is a compensatory effect of repeated endocannabinoid overstimulation or an enduring trait-like feature. An enhanced CB1R signaling may offer a new therapeutic direction for treatment of the negative affective state produced by alcohol withdrawal and abstinence, which is critical for the maintenance of alcohol addiction.
Higher plant diversity promotes higher diversity of fungal pathogens, while it decreases pathogen infection per plant
Authors: Rottstock Tanja , Joshi Jasmin , Kummer Volker , Fischer Markus 
Published: February 2014

Fungal plant pathogens are common in natural communities where they affect plant physiology, plant survival, and biomass production. Conversely, pathogen transmission and infection may be regulated by plant community characteristics such as plant species diversity and functional composition that favor pathogen diversity through increases in host diversity while simultaneously reducing pathogen infection via increased variability in host density and spatial heterogeneity. Therefore, a comprehensive understanding of multi‐host–multi‐pathogen interactions is of high significance in the context of biodiversity–ecosystem functioning. We investigated the relationship between plant diversity and aboveground obligate parasitic fungal pathogen (“pathogens” hereafter) diversity and infection in grasslands of a long‐term, large‐scale, biodiversity experiment with varying plant species (1–60 species) and plant functional group diversity (1–4 groups). To estimate pathogen infection of the plant communities, we visually assessed pathogen‐group presence (i.e., rusts, powdery mildews, downy mildews, smuts, and leaf‐spot diseases) and overall infection levels (combining incidence and severity of each pathogen group) in 82 experimental plots on all aboveground organs of all plant species per plot during four surveys in 2006.Pathogen diversity, assessed as the cumulative number of pathogen groups on all plant species per plot, increased log‐linearly with plant species diversity. However, pathogen incidence and severity, and hence overall infection, decreased with increasing plant species diversity. In addition, co‐infection of plant individuals by two or more pathogen groups was less likely with increasing plant community diversity. We conclude that plant community diversity promotes pathogen‐community diversity while at the same time reducing pathogen infection levels of plant individuals.
Fingerprinting the provenance of building stones: a case study on the Louvigné and Lanhélin granitic rocks (Armorican massif, France)
Authors: Malfilatre Claudine , Hallot Erwan , Boulvais Philippe , Poujol Marc , Chauvin Annick , Gapais Denis , Dabard Marie-Pierre , Bourquin Sylvie , Pallix Didier 
Published: February 2014

Abstract
Two examples of granitic stones from Brittany (western France) commercialized under the names of “gris-bleu de Louvigné” and “bleu de Lanhélin” were characterized in order to explore how the provenance of a building stone can be traced back with a maximum of confidence. For this purpose, petrographical, geochemical and magnetic characteristics, representing more than 70 quantitative and qualitative variables, were compiled for a total of 32 samples. We have defined two reference populations for these building stones and have extracted their discriminative characteristics. We have then compared four randomly selected samples and two foreign commercial counterparts of these stones to the reference populations.
Discriminative variables differ from one case of comparison to the other, which indicates that a combination of various tools and variables will be generally required to unequivocally fingerprint the origin of a given granitic stone. Where several quarries are mining a single geological unit within a composite intrusion, the provenance of a granitic rock can be defined at the scale of the intrusion. In addition, stones coming from two different intrusions from the same batholith can be distinguished. We conclude that the provenance of any granitic building stone is identifiable, especially if the intrinsic variability of a population of samples representative of that stone has been previously circumscribed. This study underlines that the compilation of databases for building stone identity cards is an essential first step toward the creation of official labels guaranteeing stone provenances.
Salt tectonics in the Sivas basin (Turkey): crossing salt walls and minibasins
Authors: Callot Jean-Paul , Ribes Charlotte , Kergaravat Charlie , Bonnel Cédric , Temiz Haluk , Poisson André , Vrielynck Bruno , Salel Jean-François , Ringenbach Jean-Claude 
Published: February 2014

AbstractThe Sivas basin (Turkey) shows pronounced salt tectonics activity involving the Oligocene evaporites. Despite the complete exposure of the structures, the tectonic evolution of the basin has been so far misunderstood because it has only been envisioned in a context of thrust tectonics. The core of the basin, a 35×25 km area, displays rounded minibasins separated by evaporitic walls, and partially covered by remobilized gypsum (either sedimentary or flowage). The minibasins are filled by Mid-Oligocene to Early Miocene clastics (fluvial silts and sandstones), marls, and lacustrine to marine limestones, the thickness of which may reach 4 kilometres. The stratal architecture along evaporite walls records the progressive subsidence of the minibasins, with strong rotation of beds, unconformities and local reworking of evaporites. Within the basin, the sediments show lateral thickness variations and spectacular angular unconformities. The observed geometries show striking similarities with the seismic data from petroleum basins suffering strong salt tectonism (gulf of Mexico, Precaspian basin, Angolan margin).
Fracture-fluid relationships: implications for the sealing capacity of clay layers – Insights from field study of the Blue Clay formation, Maltese islands
Authors: Missenard Yves , Bertrand Audrey , Vergély Pierre , Benedicto Antonio , Cushing Marc-Edward , Rocher Muriel 
Published: February 2014

Abstract
Sealing capacity of clay layers is a key parameter in many fields of geoscience, such as CO2 storage, hydrocarbons trapping, and waste disposal. In the context of deep geological disposal of radioactive waste, clayey formations are studied as potential host rocks. This work deals with tectonic fracturing, fluid flow, and the sealing capacity of clay layers in an outcropping formation sharing similarities to these potential host rocks. The Blue Clay formation (Maltese islands) outcrops between two limestones affected by slight extensional tectonics. Zones of oxidation around fractures are interpreted as evidence of palaeofluid circulation, and are used to assess the role of joints and faults in controlling the hydrological communication between adjacent layers. Joints and small faults (displacement &lt; 5 m) seem to die out quickly up-section within the Blue Clays, and appear to have played an insignificant role in the palaeohydrology of the area. In contrast, large faults (displacement &gt; 50 m) display clay smear structures, and the lack of oxidized zones around them suggests they served as barriers to fluid flow. Intermediate-sized faults die out up-section into complex deformation zones comprised of irregular joints that are filled with gypsum and surrounded by oxidation zones. These observations indicate that these intermediate-sized faults, usually considered as sealed by classical predictive methods such as “Shale Smear Factor”, may have played a significant role in the local palaeohydrology.