bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Second Victim Experience and Support Tool: Validation of an Organizational Resource for Assessing Second Victim Effects and the Quality of Support Resources
Authors: Burlison Jonathan D. , Scott Susan D. , Browne Emily K. , Thompson Sierra G. , Hoffman James M. 
Published: August 2014

Objectives
Medical errors and unanticipated negative patient outcomes can damage the well-being of health care providers. These affected individuals, referred to as “second victims,” can experience various psychological and physical symptoms. Support resources provided by health care organizations to prevent and reduce second victim–related harm are often inadequate. In this study, we present the development and psychometric evaluation of the Second Victim Experience and Support Tool (SVEST), a survey instrument that can assist health care organizations to implement and track the performance of second victim support resources.

Methods
The SVEST (29 items representing 7 dimensions and 2 outcome variables) was completed by 303 health care providers involved in direct patient care. The survey collected responses on second victim–related psychological and physical symptoms and the quality of support resources. Desirability of possible support resources was also measured. The SVEST was assessed for content validity, internal consistency, and construct validity with confirmatory factor analysis.

Results
Confirmatory factor analysis results suggested good model fit for the survey. Cronbach α reliability scores for the survey dimensions ranged from 0.61 to 0.89. The most desired second victim support option was “A respected peer to discuss the details of what happened.”

Conclusions
The SVEST can be used by health care organizations to evaluate second victim experiences of their staff and the quality of existing support resources. It can also provide health care organization leaders with information on second victim–related support resources most preferred by their staff. The SVEST can be administered before and after implementing new second victim resources to measure perceptions of effectiveness.
Assessing the bank profitability in the MENA region
Authors: Ben Selma Mokni Rim , Rachdi Houssem 
Published: August 2014

Purpose
– Which of the banking stream is relatively more profitable in Middle Eastern and North Africa (MENA) region?

Design/methodology/approach
– The empirical study covers a sample of 15 conventional and 15 Islamic banks for the period 2002-2009.The authors estimate models using the generalized method of moments in system, of Blundell and Bond (1998). They exploit an up-to-date econometric technique which takes into consideration the issue of endogeneity of regressors to evaluate the comparative profitability of Islamic and conventional banks in the MENA region.

Findings
– Empirical analysis results show that the determinants’ significance varies between Islamic and conventional banks. Profitability seems to be quite persistent in the MENA region reflecting a higher degree of government intervention and may signal barriers to competition.

Originality/value
– The main interest is to develop a comprehensive model that integrates macroeconomic, industry-specific and bank-specific determinants. The paper makes comparison of the performance between two different banking systems in the MENA region. The authors consider a variable crisis to gain additional insights into the impacts of the financial crisis on MENA banking sector.
Derivative products and innovation in Islamic finance
Authors: Kiong Kok Seng , Giorgioni Gianluigi , Laws Jason 
Published: August 2014

Purpose– The purpose of this paper is to highlight the possibility of structuring an Islamic option which includes an element of risk sharing as opposed to risk transfer.Design/methodology/approach– The approach adopted in this research involved a combination of a wa’ad (promise) and murabaha (cost plus sale) and examining if they could form a risk-sharing Islamic option. The payoffs were assumed to be dependent on bi-period outcomes.Findings– The paper attempted to create a hybrid risk-sharing option by combining elements of both wa’ad (promise) and murabaha (cost plus sale). The results yielded are dependent on the eventual direction of the market (in-the-money, at-the-money and out-the-money). While the results are not definitive, they do provide arguments for the adoption of a risk-sharing, as opposed to a risk-transfer, methodology when it comes to structuring risk management instruments.Research limitations/implications– One of the major limitations of this research is the inability to assess the Shariah compliance of the proposed instrument. Shariah compliance is determined by a Shariah Supervisory Board, and every effort has been made to ensure that Shariah financial principles are adhered to in the creation of this structure.Practical implications– The structure provides some interest arguments in the creation of risk management tools under a Shariah financial framework. The structure illustrates the benefits of having a risk-sharing mode over the conventional risk-transfer stances of most risk management tools.Originality/value– The paper offers a new way of structuring a risk management tool in Islamic finance. It explores the highly debated area of derivatives in Islamic finance and proposes a new way of creating a risk management tool that involves some elements of risk sharing.
Opinion of the zakat recipients on their food security: a case study on Bangladesh
Authors: Tanvir Mahmud Kazi , Kabir Hassan M. , Ferdous Alam Md. , Sohag Kazi , Rafiq Farhana 
Published: August 2014

Purpose
– The purpose of this paper is to assess the impact of zakat fund on the food expenditure of the households to assess the impact of zakat fund on the agricultural production of the households and to assess the opinion of the zakat recipients on food security status under zakat program.

Design/methodology/approach
– Samples were selected for this study using the simple random sampling (SRS) technique. A total of 149 households were selected from 196 households. A survey was conducted during January to March 2011 among the project beneficiaries using questionnaire. The ordinary least squares technique was used to assess the impact of zakat on food security status of the zakat recipients. Heteroscedasticity problem was detected in this study which was corrected using White's method. Logit model was used to assess the opinions of the zakat recipients on their food security status under the Hasana project.

Findings
– This study shows that amount of zakat provided to the poor recipients failed to create any significant influence on their agricultural production, food expenditure and food security status. The study also shows that household income, family members’ involvement in agricultural activities and numbers of income-generating activities pursued by the households were the key determinants of households’ food consumption.

Originality/value
– This study helps in assessing the opinion of the zakat recipients about the effectiveness of the zakat program on their living standard in terms of household agricultural production and food security and also assisting in policy planning for alleviating rural poverty in Bangladesh through the zakat system.
Lutein supplementation leads to decreased soluble complement membrane attack complex sC5b‐9 plasma levels
Authors: Tian Yuan , Kijlstra Aize , van der Veen Rob L. P. , Makridaki Maria , Murray Ian J. , Berendschot Tos T. J. M. 
Published: August 2014

AbstractPurposeThe purpose of this study was to investigate the effect of lutein on systemic complement activation in elderly individuals.MethodsSeventy patients with signs of early age‐related macular degeneration (AMD) were included in this study. All subjects were randomly assigned to receive a 10 mg daily dose of lutein or a placebo for a time period of 1 year. EDTA blood was collected before and at various time‐points during the study (0, 4, 8 and 12 months). The plasma level of the soluble complement membrane attack complex sC5b‐9 was measured by ELISA.ResultsWe found a significant 1.1 ng/ml monthly decrease in the plasma sC5b‐9 concentration in the lutein group (p < 0.001), resulting in a decrease from 60.3 ng/ml at baseline to 46.3 ng/ml at 12 months. For the placebo group, we found a significant 0.6 ng/ml monthly increase in plasma sC5b‐9 concentration (p = 0.001), resulting in an increase from 51.6 ng/ml at baseline to 58.4 ng/ml at 12 months.ConclusionsLutein supplementation inhibits the systemic activation of the complement system, which provides further functional evidence for the reported beneficial effects of this carotenoid in the management of AMD.
A randomized trial to compare the safety and efficacy of two ranibizumab dosing regimens in a Turkish cohort of patients with choroidal neovascularization secondary to AMD
Authors: Eldem Bora M. , Muftuoglu Gulipek , Topbaş Seyhan , Çakir Mehmet , Kadayifcilar Sibel , Özmert Emin , Bahçecioğlu Halil , Sahin Feride , Sevgi Serhan ,   the SALUTE study group
Published: August 2014

AbstractPurposeTo compare visual outcomes, number of visits and ranibizumab injections in patients treated with a Wait & Extend (W&E) or Treat & Observe (T&O) regimen.MethodsThis 12‐month, randomized, multicentre, open‐label study enrolled patients aged ≥50 years with choroidal neovascularization (CNV) secondary to AMD who had not received anti‐VEGF agents. Patients received three monthly injections of ranibizumab before randomization (1:1): (i) T&O patients were examined monthly and retreated if needed, (ii) W&E patients had a follow‐up visit 1 month later. If no lesions were active, the interval to the next visit was extended by 2 weeks to a maximum of 8 weeks. Active lesions were re‐treated and the follow‐up schedule restarted. Primary end‐point was change in BCVA at Month 12.ResultsOf the 104 screened patients, 99 were eligible and received ≥1 ranibizumab injection; 93 were randomized (T&O: 45, W&E: 48). The median (interquartile range [IQR]) change in BCVA (logMAR) from baseline at Month 12 was similar between groups (T&O: −0.12 [0.38]; W&E: −0.18 [0.32], p = 0.267). Median (IQR) number of visits at study end (including screening, baseline and control visit after 1st injection) was 15.0 (1.0) for T&O, and 12.0 (2.0) for W&E (p < 0.001). Injection numbers were similar between groups (median [IQR]: 6.0 [3.0] and 5.0 [4.0], respectively, p = 0.215). Adverse events were similar between groups.ConclusionW&E regimen resulted in a similar efficacy and safety profile to the labelled T&O regimen in patients with CNV secondary to AMD, and may help reduce the burden of follow‐up visits.
Episodic memory impairments in bipolar disorder are associated with functional and structural brain changes
Authors: Oertel‐Knöchel Viola , Reinke Britta , Feddern Richard , Knake Annika , Knöchel Christian , Prvulovic David , Pantel Johannes , Linden David EJ 
Published: August 2014

ObjectivesWe combined multimodal functional magnetic resonance imaging (fMRI) and structural magnetic resonance imaging to probe abnormalities in brain circuits underpinning episodic memory performance deficits in patients with bipolar disorder (BD).MethodsWe acquired whole‐brain fMRI data in 21 patients with BD and a matched group of 20 healthy controls during a non‐verbal episodic memory task, using abstract shapes. We also examined density of gray matter, using voxel‐based morphometry (VBM), and integrity of connecting fiber tracts, using diffusion tensor imaging (DTI) and tract‐based spatial statistics, for areas with significant activation differences.ResultsPatients with BD remembered less well than controls which shapes they had seen and had lower activation levels during the encoding stage of the task in the anterior cingulate gyrus, the precuneus/cuneus bilaterally, and the left lingual gyrus, and higher activation levels during the retrieval stage in the left temporo‐parietal junction. Patients with BD showed reduced gray matter volumes in the left anterior cingulate, the precuneus/cuneus bilaterally, and the left temporo‐parietal region in comparison with controls. DTI revealed increased radial, axial, and mean diffusivity in the left superior longitudinal fascicle in patients with BD compared with controls.ConclusionsChanges in task‐related activation in frontal and parietal areas were associated with poorer episodic memory in patients with BD. Compared with data from single imaging modalities, integration of multimodal neuroimaging data enables the building of more complete neuropsychological models of mental disorders.
MYD88 L265P mutation contributes to the diagnosis of Bing Neel syndrome
Authors: Poulain Stéphanie , Boyle Eileen M. , Roumier Christophe , Demarquette Hélène , Wemeau Mathieu , Geffroy Sandrine , Herbaux Charles , Bertrand Elisabeth , Hivert Bénédicte , Terriou Louis , Verrier Albert , Pollet Jean Paul , Maurage Claude Alain , Onraed Brigitte , Morschhauser Franck , Quesnel Bruno , Duthilleul Patrick , Preudhomme Claude , Leleu Xavier 
Published: August 2014

SummaryBing‐Neel syndrome (BNS), a rare neurological syndrome associated with Waldenström macroglobulinaemia (WM), is a direct involvement of the central nervous system by lymphoplasmacytoid cells characterized with an adverse prognostic. The MYD88 L265P mutation has been identified in the vast majority of patients with WM. The diagnosis of BNS is often challenging because of the variety of clinical presentations associated with difficult histological techniques. We hypothesized that identification of MYD88 L265P mutation in the cerebrospinal fluid (CSF) would contribute to the diagnosis of BNS in addition to imaging, flow cytometry and cytology. We identified MYD88 L265P mutation in the CSF and the bone marrow of all cases of BNS using quantitative polymerase chain reaction qPCR and Sanger sequencing. Copy neutral loss of heterozygosity including MYD88 was observed in one case. No mutation of CXCR4, CD79A and CD79B was observed in parallel. We further showed that monitoring the quantitative expression of MYD88 L265P mutation might be a useful molecular tool to monitor response to chemotherapy using qPCR. In conclusion, identification of MYD88 L265P mutation might be a new molecular‐based biomarker tool to add to the diagnostic and monitoring armamentarium for BNS.
Differences in prevalence of bullying victimization between native and immigrant children in the Nordic countries: a parent‐reported serial cross‐sectional study
Authors: Bjereld Y. , Daneback K. , Petzold M. 
Published: August 2014

AbstractBackgroundBullying among children is a problem with severe consequences for the victim. The present study examined parent‐reported bullying victimization among children in the Nordic countries at two points in time, 1996 and 2011, and studied differences in prevalence of bullying victimization between immigrant and native children.MethodsData came from the parent‐reported NordChild, carried out in the Nordic countries in 1996 and 2011. NordChild is a serial cross‐sectional comparative study. A total of 7107 children aged 7–13 were included in the analyses.ResultsThe prevalence of bullying victimization in the total Nordic countries was lower in 2011 (19.2%) than 1996 (21.7%). Difference in prevalence of bullying victimization was found both between native and immigrant children, and between countries. The largest difference in prevalence of bullying victimization was measured in Sweden 2011, where 8.6% of the native children were bullied, to be compared with the 27.8% of the immigrant children. Immigrant children had higher odds to be bullied than native children in Norway, Sweden and in the total Nordic countries at both measurements, also when adjusted for potentially confounding factors.ConclusionsThe higher prevalence of bullying victimization among immigrant children should be taken into consideration in the design and development of preventive work against bullying.
Expression of leptin and its receptor in thyroid carcinoma: distinctive prognostic significance in different subtypes
Authors: Fan Yan‐Lan , Li Xiao‐Qiu 
Published: August 2014

SummaryObjectiveTo investigate the potential prognostic significance of leptin and its receptor (Ob‐R) in thyroid carcinoma.Patients and MethodsThe study cohort consisted of 173 patients including 93 cases with papillary thyroid carcinoma (PTC), 41 cases with follicular thyroid carcinoma (FTC), 25 cases with medullary thyroid carcinoma (MTC) and 14 cases with anaplastic thyroid carcinoma (ATC). We investigated the correlation between clinicopathological features and leptin or Ob‐R. The Kaplan–Meier method was used to analyse the survival rate.ResultsThere was a strong correlation of leptin expression with Ob‐R expression in PTC, FTC and ATC. For PTC, leptin expression was strongly correlated with older age, larger tumour size, nodal metastasis and advanced stage. Ob‐R was significantly correlated with larger tumour size, nodal metastasis and advanced stage. The 5‐year disease‐free survival (DFS) rate in patients with positive leptin or its receptor expression was lower than that in patients without expression (with statistical difference). For FTC, patients with positive leptin or Ob‐R expression developed no recurrence or metastasis during the follow‐up. For MTC, Ob‐R was significantly correlated with nodal metastasis and advanced stage (P < 0·05). For ATC, patients with positive Ob‐R expression had longer median DFS than those with negative expression (436 ± 185 vs 57 ± 71 days), and the difference in the survival rate was statistically significant (P < 0·05).ConclusionsThere was a strong correlation of leptin expression with Ob‐R expression in PTC, FTC and ATC. Leptin and Ob‐R had negative prognostic significance in PTC, while Ob‐R may play a protective role in ATC.
A population‐based nested case–control study: the use of 5‐alpha‐reductase inhibitors and the increased risk of osteoporosis diagnosis in patients with benign prostate hyperplasia
Authors: Lin Wen‐Ling , Hsieh Yow‐Wen , Lin Cheng‐Li , Sung Fung‐Chang , Wu Chieh‐Hsi , Kao Chia‐Hung 
Published: August 2014

SummaryBackground5‐alpha‐reductase inhibitors (5ARIs) are the potent androgen responsible for the development and enlargement of the prostate gland by decreasing dihydrotestosterone (DHT). This results in inhibition of the conversion of testosterone to dihydrotestosterone and markedly suppresses serum dihydrotestosterone levels. Testosterone replacement therapy improves bone density in men with hypogonadal osteoporosis. This study explores the possible association between the use of two typical 5ARIs (finasteride and dutasteride) and the subsequent risk of osteoporosis diagnosis.MethodsWe identified 1352 osteoporosis diagnosis cases and 5387 control cases without osteoporosis diagnosis from the claims data for patients with benign prostate hyperplasia (BPH), which are collected in the Taiwanese National Health Insurance Research Database (NHIRD). Four controls were frequency matched to each case according to age (every 5 years) and diagnosis date. We measured the effect of 5ARIs and determined the adjusted odds ratios (ORs) with 95% confidence intervals (CIs).ResultsWe observed a 1·52‐fold increase in osteoporosis diagnosis among patients with BPH using finasteride (95% CI, 1·01–2·30). Furthermore, a dosage analysis showed that higher doses of finasteride were associated with higher osteoporosis diagnosis risk (OR = 1·68; 95% CI, 1·01–2·81), relative to the patients not using 5ARIs.ConclusionThis population‐based nested case–control study suggests that the use of finasteride can increase the risk of osteoporosis diagnosis among patients with BPH. The effects were more prominent in patients using higher doses of finasteride.
Impact of mass rearing and gamma irradiation on thermal tolerance ofEldana saccharina
Authors: Mudavanhu Pride , Addison Pia , Conlong Des E. 
Published: August 2014

AbstractMating ability, survival, and fitness of mass‐produced sterile insects when released into the wild, are critical to the success of the sterile insect technique (SIT) as a pest management strategy, but their field performance remains one of the greatest challenges. Thermal stress tolerance by irradiated insects is a determinant of sterile insect quality, hence knowledge of their physiological competitiveness is essential for developing theSIT. Here, we report the results of experiments investigating effects of laboratory rearing and increasing radiation dosage on thermal limits to activity of the adult stage ofEldana saccharinaWalker (Lepidoptera:Pyralidae). The critical thermal maximum (CTmax) and critical thermal minimum (CTmin) were assayed using a dynamic method on both sexes ofE. saccharinamoths in laboratory vs. wild populations (to determine effect of rearing history). Furthermore, the laboratory population was exposed to 150, 200, and 250 Gy, to determine the effect of radiation dose. Laboratory‐rearedE. saccharinawere more heat tolerant compared to wild moths for both sexes (CTmax = 44.5 vs. 44.3 °C), whereas in the case ofCTmin (3.7 vs. 4.4 °C), wild moths were more cold tolerant than their laboratory‐reared counterparts. Irradiation had a negative effect on bothCTmax andCTmin. Moths treated at the lowest radiation dose were more cold and heat tolerant than those treated at the highest dosages (CTmin = 4.5 vs. 6.2 °C;CTmax = 43.9 vs. 43.5 °C), thereby reinforcing the importance of lower dosages rather than those that induce full sterility againstE. saccharina. In general, sex had no influence on critical thermal limits in all moth treatments except for those irradiated at 150 Gy. The data presented in this article provide evidence that increasing radiation dose impacts on fitness of laboratory‐produced moths relative to their wild counterparts, which in turn could affect the effectiveness of theSITprogramme.
Association between carotid stenosis or lacunar infarction and incident dementia in patients with vascular risk factors
Authors: Kitagawa K. , Miwa K. , Yagita Y. , Okazaki S. , Sakaguchi M. , Mochizuki H. 
Published: August 2014

Background and purposeThe association between vascular risk factors and dementia is of interest. Several studies have shown that cerebral small vessel disease (SVD) is associated with dementia. However, the association between cerebral large vessel disease (LVD) and dementia has not been thoroughly examined.MethodsThe Osaka Follow‐up Study for Carotid Atherosclerosis, Part 2, was a prospective cohort study of cardiovascular events and dementia in which patients (n = 1106) with vascular risk factors underwent carotid ultrasound. Of these patients, 600 who had normal cognitive function were included and underwent brain magnetic resonance imaging. The presence of lacunar infarction and carotid stenosis served as markers for SVD and LVD, respectively.ResultsAmongst 600 patients (mean 68 years, 57% men), 261 (44%) showed lacunar infarction and 94 (16%) showed carotid stenosis. During the follow‐up period (median 8.0 years), 57 patients had incident dementia. Patients with carotid stenosis and lacunar infarction were significantly more likely to be diagnosed with dementia (log‐rank test, P = 0.037 and P < 0.001, respectively). The association between lacunar infarction and dementia remained significant after adjusting for risk factors including stroke history, apolipoprotein E genotype and years of education (hazard ratio 2.64, 95% confidence interval 1.22–6.09). However, the presence of carotid stenosis was not associated with incident dementia after adjusting for age and sex (P = 0.477).ConclusionsThis study demonstrated that carotid stenosis had little association with dementia, but lacunar infarction had a significant association. The impact of SVD on dementia could be much greater than that of LVD.