bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone H3 lysine 9 trimethylation is required for suppressing the expression of an embryonically activated retrotransposon in Xenopus laevis
Authors: Herberg Sarah , Simeone Angela , Oikawa Mami , Jullien Jerome , Bradshaw Charles R , Teperek Marta , Gurdon John , Miyamoto Kei 
Published: September 2015

AbstractTransposable elements in the genome are generally silenced in differentiated somatic cells. However, increasing evidence indicates that some of them are actively transcribed in early embryos and the proper regulation of retrotransposon expression is essential for normal development. Although their developmentally regulated expression has been shown, the mechanisms controlling retrotransposon expression in early embryos are still not well understood. Here, we observe a dynamic expression pattern of retrotransposons with three out of ten examined retrotransposons (1a11, λ-olt 2-1 and xretpos(L)) being transcribed solely during early embryonic development. We also identified a transcript that contains the long terminal repeat (LTR) of λ-olt 2-1 and shows a similar expression pattern to λ-olt 2-1 in early Xenopus embryos. All three retrotransposons are transcribed by RNA polymerase II. Although their expression levels decline during development, the LTRs are marked by histone H3 lysine 4 trimethylation. Furthermore, retrotransposons, especially λ-olt 2-1, are enriched with histone H3 lysine 9 trimethylation (H3K9me3) when their expression is repressed. Overexpression of lysine-specific demethylase 4d removes H3K9me3 marks from Xenopus embryos and inhibits the repression of λ-olt 2-1 after gastrulation. Thus, our study shows that H3K9me3 is important for silencing the developmentally regulated retrotransposon in Xenopus laevis.
Photocurrent enhancements of organic solar cells by altering dewetting of plasmonic Ag nanoparticles
Authors: Fleetham Tyler , Choi Jea-Young , Choi Hyung Woo , Alford Terry , Jeong Doo Seok , Lee Taek Sung , Lee Wook Seong , Lee Kyeong-Seok , Li Jian , Kim Inho 
Published: September 2015

AbstractIncorporation of metal nanoparticles into active layers of organic solar cells is one of the promising light trapping approaches. The size of metal nanoparticles is one of key factors to strong light trapping and the size of thermally evaporated metal nanoparticles can be tuned by either post heat treatment or surface modification of substrates. We deposited Ag nanoparticles on ITO by varying nominal thicknesses and post annealing was carried out to increase their size in radius. PEDOT:PSS was employed onto the ITO substrates as a buffer layer to alter the dewetting behavior of Ag nanoparticles. The size of Ag nanoparticles on PEDOT:PSS were dramatically increased by more than three times compared to those on the ITO substrates. Organic solar cells were fabricated on the ITO and PEDOT:PSS coated ITO substrates with incorporation of those Ag nanoparticles and their performances were compared. The photocurrents of the cells with the active layers on PEDOT:PSS with an optimal choice of the Ag nanoparticles were greatly enhanced whereas the Ag nanoparticles on the ITO substrates did not lead to the photocurrent enhancements. The origin of the photocurrent enhancements with introducing the Ag nanoparticles on PEDOT:PSS are discussed.
Nanoparticle conjugation enhances the immunomodulatory effects of intranasally delivered CpG in house dust mite-allergic mice
Authors: Ballester Marie , Jeanbart Laura , de Titta Alexandre , Nembrini Chiara , Marsland Benjamin J. , Hubbell Jeffrey A. , Swartz Melody A. 
Published: September 2015

AbstractAn emerging strategy in preventing and treating airway allergy consists of modulating the immune response induced against allergens in the lungs. CpG oligodeoxynucleotides have been investigated in airway allergy studies, but even if promising, efficacy requires further substantiation. We investigated the effect of pulmonary delivery of nanoparticle (NP)-conjugated CpG on lung immunity and found that NP-CpG led to enhanced recruitment of activated dendritic cells and to Th1 immunity compared to free CpG. We then evaluated if pulmonary delivery of NP-CpG could prevent and treat house dust mite-induced allergy by modulating immunity directly in lungs. When CpG was administered as immunomodulatory therapy prior to allergen sensitization, we found that NP-CpG significantly reduced eosinophilia, IgE levels, mucus production and Th2 cytokines, while free CpG had only a moderate effect on these parameters. In a therapeutic setting where CpG was administered after allergen sensitization, we found that although both free CpG and NP-CpG reduced eosinophilia and IgE levels to the same extent, NP conjugation of CpG significantly enhanced reduction of Th2 cytokines in lungs of allergic mice. Taken together, these data highlight benefits of NP conjugation and the relevance of NP-CpG as allergen-free therapy to modulate lung immunity and treat airway allergy.
Search for aflatoxin and trichothecene production inhibitors and analysis of their modes of action
Authors: Sakuda Shohei , Yoshinari Tomoya , Furukawa Tomohiro , Jermnak Usuma , Takagi Keiko , Iimura Kurin , Yamamoto Toshiyoshi , Suzuki Michio , Nagasawa Hiromichi 
Published: September 2015

AbstractMycotoxin contamination of crops is a serious problem throughout the world because of its impact on human and animal health as well as economy. Inhibitors of mycotoxin production are useful not only for developing effective methods to prevent mycotoxin contamination, but also for investigating the molecular mechanisms of secondary metabolite production by fungi. We have been searching for mycotoxin production inhibitors among natural products and investigating their modes of action. In this article, we review aflatoxin and trichothecene production inhibitors, including our works on blasticidin S, methyl syringate, cyclo(l-Ala-l-Pro), respiration inhibitors, and precocene II.
Incorporating longitudinal pediatric patient-centered outcome measurement into the clinical workflow using a commercial electronic health record: a step toward increasing value for the patient
Authors: Carberry Kathleen , Landman Zachary , Xie Michelle , Feeley Thomas , Henderson John , Fraser Charles 
Published: September 2015

Abstract
Patient-centered outcomes measurement provides healthcare organizations with crucial information for increasing value for patients; however, organizations have struggled to obtain outcomes data from electronic health record (EHR) systems. This study describes how Texas Children’s Hospital customized a commercial EHR system and assembled a cross-functional team to capture outcomes data using existing functionality. Prior to its installation and customization, no surgical subspecialties besides the congenital heart and transplant surgery groups conducted prospective, patient outcomes measurement, but by 2015, the outcomes of over 1300 unique patients with supracondylar fractures, cleft lip and/or palate, or voiding dysfunction had been tracked. Key factors for integrating outcomes measurement into the clinical workflow include ongoing communication between cross-functional teams composed of clinicians and technical professionals, an iterative design process, organizational commitment, and prioritizing measurement as early as possible during EHR optimization.
Trends in Pain Medicine Liability
Authors: Pollak Kelly A. , Stephens Linda S. , Posner Karen L. , Rathmell James P. , Fitzgibbon Dermot R. , Dutton Richard P. , Michna Edward , Domino Karen B. 
Published: September 2015

AbstractAbstract
In a review of the Anesthesia Closed Claims Project database, the proportion of malpractice claims in pain medicine increased from 3% in 1980–1989 to 18% in 2000–2012, accompanied by increasing severity of injury, including death and permanent disabling injury. Claims related to cervical procedures were out of proportion to the frequency with which they are performed.

Background
The authors examined changes in the frequency of pain medicine malpractice claims and associated treatment modalities and outcomes over time.

Methods
The authors analyzed trends in pain medicine claims from 1980 to 2012 in the Anesthesia Closed Claims Project database by binary logistic regression on year of event. Pain procedures in claims from 2000 to 2012 were compared with the proportion of pain procedures reported to the National Anesthesia Clinical Outcomes Registry in 2010–2014.

Results
Malpractice claims for pain medicine increased from 3% of 2,966 total malpractice claims in the Anesthesia Closed Claims Project database in 1980–1989 to 18% of 2,743 anesthesia claims in 2000–2012 (odds ratio [OR], 1.088 per year; 95% CI, 1.078 to 1.098; P < 0.001). Outcomes in pain claims became more severe over time, with increases in death and permanent disabling injury (OR, 1.094 per year; P < 0.001). Nonneurolytic cervical injections increased to 27% of pain claims in 2000–2012 (OR, 1.054; P < 0.001), whereas National Anesthesia Clinical Outcomes Registry demonstrates that lumbar injections are a more common procedure. Claims associated with medication management increased to 17% of pain claims in 2000–2012 (OR, 1.116 per year; P < 0.001).

Conclusions
Pain medicine claims have increased over time and have increased in severity. Claims related to cervical procedures were out of proportion to the frequency with which they are performed. These liability findings suggest that pain specialists should aggressively continue the search for safer and more effective therapies.
Relationships Among Daytime Napping and Fatigue, Sleep Quality, and Quality of Life in Cancer Patients
Authors: Sun Jia-Ling , Lin Chia-Chin 
Published: September 2015

Background:
The relationships among napping and sleep quality, fatigue, and quality of life (QOL) in cancer patients are not clearly understood.

Objective:
The aim of the study was to determine whether daytime napping is associated with nighttime sleep, fatigue, and QOL in cancer patients.

Methods:
In total, 187 cancer patients were recruited. Daytime napping, nighttime self-reported sleep, fatigue, and QOL were assessed using a questionnaire. Objective sleep parameters were collected using a wrist actigraph.

Results:
According to waking-after-sleep-onset measurements, patients who napped during the day experienced poorer nighttime sleep than did patients who did not (t = −2.44, P = .02). Daytime napping duration was significantly negatively correlated with QOL. Patients who napped after 4 PM had poorer sleep quality (t = −1.93, P = .05) and a poorer Short-Form Health Survey mental component score (t = 2.06, P = .04) than did patients who did not. Fatigue, daytime napping duration, and sleep quality were significant predictors of the mental component score and physical component score, accounting for 45.7% and 39.3% of the variance, respectively.

Conclusions:
Daytime napping duration was negatively associated with QOL. Napping should be avoided after 4 PM.

Implications for Practice:
Daytime napping affects the QOL of cancer patients. Future research can determine the role of napping in the sleep hygiene of cancer patients.
Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis
Authors: Fan Jean , Salathia Neeraj , Liu Rui , Kaeser Gwen , Yung Yun , Herman Joseph , Kaper Fiona , Fan Jian-Bing , Zhang Kun , Chun Jerold , Kharchenko Peter V. 
Published: September 2015

AbstractSingle-cell transcriptome measurements are being applied at rapidly increasing scales to study cellular repertoires underpinning functions of complex tissues and organs, including mammalian brains. The transcriptional state of each cell, however, reflects a variety of biological factors, including persistent cell-type specific regulatory configurations, transient processes such as cell cycle, local metabolic demands, and extracellular signals. Depending on the biological setting, all such aspects of transcriptional heterogeneity can be of potential interest, but detecting complex heterogeneity structure from inherently uncertain single-cell data presents analytical challenges. We developed PAGODA to resolve multiple, potentially overlapping aspects of transcriptional heterogeneity by identifying known pathways or novel gene sets that show significant excess of coordinated variability among the measured cells. We demonstrate that PAGODA effectively recovers the subpopulations and their corresponding functional characteristics in a variety of single-cell samples, and use it to characterize transcriptional diversity of neuronal progenitors in the developing mouse cortex.
A collection explosion: finding our collection roots and examining how we got from there to here
Authors: Laskowski Mary S. , Maddox Abbott Jennifer A. , Norman Michael A. 
Published: September 2015

Purpose
– The purpose of this paper is to present research findings from a project to identify, locate and examine the first collection of a large academic research institution. The article also examines changes in collections over time and some of the factors influencing changing collection development policies and practice.

Design/methodology/approach
– Methodology included historical archival research, collection discovery and item by item comparison.

Findings
– As electronic access, shared repositories and access to shared content reshape the collection development landscape, the emphasis is shifting toward global access and unique local content. And yet, we see that this new model is built on a solid foundation of collection development almost 150 years in the making.

Originality/value
– Understanding how the University Library got to where it is will help inform future decisions and directions regarding collection development, and allow others to compare our findings against their own institutional growth and forward trajectory.
Cross-country technology gap in Latin America
Authors: Misra Kaustav , Memili Esra , Welsh Dianne H.B. , Reddy Surender , Sype Gail E. 
Published: September 2015

Purpose
– The purpose of this paper is to investigate the factors influencing the total factor productivity (TFP) gap between the USA and eight Latin American countries for the period of 1970-2000.

Design/methodology/approach
– The paper provides an explicit application of TFP estimation by employing a growth accounting approach (Solow Residual) in the presence of non-constant returns to scale and a non-parametric approach (DEA – Malmquist Index) while relaxing the scale-related constraint. A macro-based economic model of innovator and follower countries is employed to explore the linkage between technology gaps and innovations, labor productivity, trade openness, foreign direct investment, and adult workforce illiteracy rates. A pooled model and a fixed effects model are used to determine the factors of the technology gap between the innovator and the follower countries.

Findings
– The results show that the labor productivity gap, adult work force illiteracy rates, patent filing gap, and trade openness are significant determinants of the technology gap between innovator and follower country.

Practical implications
– Latin American countries would benefit from the technology diffusion from an innovator country; but a minimum threshold of human capital, such as adult workforce illiteracy rates and patent filing has to be met. The authors find government policies on trade openness also have large effects on technology limitations in foreign countries.

Originality/value
– This paper is of value to researchers, policy makers, and economic development specialists trying to improve the rate of technology adoption and innovation.
An ontology-based web service framework for construction supply chain collaboration and management
Authors: Das Moumita , Cheng Jack C.P. , Law Kincho H. 
Published: September 2015

Purpose
– The purpose of this paper is to present a framework for integrating construction supply chain in order to resolve the data heterogeneity and data sharing problems in the construction industry.

Design/methodology/approach
– Standardized web service technology is used in the proposed framework for data specification, transfer, and integration. Open standard SAWSDL is used to annotate web service descriptions with pointers to concepts defined in ontologies. NoSQL database Cassandra is used for distributed data storage among construction supply chain stakeholders.

Findings
– Ontology can be used to support heterogeneous data transfer and integration through web services. Distributed data storage facilitates data sharing and enhances data control.

Practical implications
– This paper presents examples of two ontologies for expressing construction supply chain information – ontology for material and ontology for purchase order. An example scenario is presented to demonstrate the proposed web service framework for material procurement process involving three parties, namely, project manager, contractor, and material supplier.

Originality/value
– The use of web services is not new to construction supply chains (CSCs). However, it still faces problems in channelizing information along CSCs due to data heterogeneity. Trust issue is also a barrier to information sharing for integrating supply chains in a centralized collaboration system. In this paper, the authors present a web service framework, which facilitates storage and sharing of information on a distributed manner mediated through ontology-based web services. Security is enhanced with access control. A data model for the distributed databases is also presented for data storage and retrieval.
A 4D automatic simulation tool for construction resource planning: a case study
Authors: Li Heng , Chan Greg , Skitmore Martin , Huang Ting 
Published: September 2015

Purpose– Traditional construction planning relies upon the critical path method and bar charts. Both of these methods suffer from visualization and timing issues that could be addressed by 4D technology specifically geared to meet the needs of the construction industry. The purpose of this paper is to propose a new construction planning approach based on simulation by using a game engine.Design/methodology/approach– A 4D automatic simulation tool was developed and a case study was carried out. The proposed tool was used to simulate and optimize the plans for the installation of a temporary platform for piling in a civil construction project in Hong Kong. The tool simulated the result of the construction process with three variables: equipment, site layout and schedule. Through this, the construction team was able to repeatedly simulate a range of options.Findings– The results indicate that the proposed approach can provide a user-friendly 4D simulation platform for the construction industry. The simulation can also identify the solution being sought by the construction team. The paper also identifies directions for further development of the 4D technology as an aid in construction planning and decision making.Research limitations/implications– The tests on the tool are limited to a single case study and further research is needed to test the use of game engines for construction planning in different construction projects to verify its effectiveness. Future research could also explore the use of alternative game engines and compare their performance and results.Originality/value– The authors proposed the use of game engine to simulate the construction process based on resources, working space and construction schedule. The developed tool can be used by end-users without simulation experience.
Differentials in child nutrition and immunization among migrants and non-migrants in Urban India
Authors: Prusty Ranjan Kumar , Keshri Kunal 
Published: September 2015

Purpose
– The purpose of this paper is to understand disparities in child immunization and nutritional status among children by migration status in urban India.

Design/methodology/approach
– The study utilized third round of National Family Health Survey (NFHS, 2005-2006) data, which is the Indian version of Demographic and Health Survey. Descriptive statistics and binary logistic regression models were used to study the levels and factors associated with child nutrition and immunization by migration status.

Findings
– Results suggest that malnutrition and no immunization are very high among children of rural-urban migrants and full immunization is lower than urban non-migrants and urban-urban migrants. More than half of the children from marginalized households suffer from the problem of undernutrition among rural-urban migrants. Multivariate results show economic status, age of the mother, education, caste and media exposure are negatively associated with malnutrition and positively associated with immunization. Children from south, north-east and east are found to have lesser chance of being malnourished than north region of India.

Practical implications
– The challenges experienced by rural-urban migrants are reflected over their children and needs a greater attention among policy makers in India.

Originality/value
– The finding of this study that children of the rural-urban migrants are in a disadvantageous position in terms of nutrition and immunization. This reflects the precarious condition of rural-urban migrants who initially settles in poor neighbourhoods, which are characterized by lack of adequate sanitation and clean water, poor housing and overcrowding, and difficulty in access to modern health services brought out by many researchers.
Global managers
Authors: Barakat Livia L. , Lorenz Melanie P , Ramsey Jase R. , Cretoiu Sherban L 
Published: September 2015

Purpose– The purpose of this paper is to examine the effect of cultural intelligence (CQ) on the job performance of global managers.Design/methodology/approach– In total, 332 global managers were surveyed from multinational companies operating in Brazil. The mediating effect of job satisfaction was tested on the CQ-job performance relationship.Findings– The findings suggest that job satisfaction transmits the effect of CQ to job performance, such that global managers high in CQ exhibit more job satisfaction in an international setting, and therefore perform better at their jobs.Practical implications– Results imply that global managers should increase their CQ in order to improve their job satisfaction and ultimately perform better in an international context.Originality/value– The authors make three primary contributions to the international business literature. First, the authors introduce job satisfaction as a possible outcome variable of CQ. Thus, this work is the first empirical study to test the effect of CQ on the job satisfaction of global managers. Second, although the job satisfaction-job performance relationship is recurrently discussed in the organizational behavior literature, it is not often explicitly associated with global managers that are working in cross-cultural settings. Finally, the authors posit that job satisfaction mediates the relationship between CQ and job performance.