bluuebunny/crossref_metadata_2025_split huggingface dataset:
In situ changes of tropical crustose coralline algae along carbon dioxide gradients
Authors: Fabricius K. E. , Kluibenschedl A. , Harrington L. , Noonan S. , De'ath G. 
Published: April 2015

AbstractCrustose coralline algae (CCA) fulfill important ecosystem functions in coral reefs, including reef framework stabilization and induction of larval settlement. To investigate in situ the effects of high carbon dioxide on CCA communities, we deployed settlement tiles at three tropical volcanic CO2 seeps in Papua New Guinea along gradients spanning from 8.1 to 7.4 pH. After 5 and 13 months deployment, there was a steep transition from CCA presence to absence around pH 7.8 (660 μatm pCO2): 98% of tiles had CCA at pH > 7.8, whereas only 20% of tiles had CCA at pH ≤ 7.8. As pH declined from 8.0 to 7.8, the least and most sensitive CCA species lost 43% and 85% of cover, respectively. Communities on upward facing surfaces exposed to high light and high grazing pressure showed less steep losses than those on shaded surfaces with low grazing. Direct CO2 effects on early life stages were the main mechanisms determining CCA cover, rather than competitive interactions with other benthic groups. Importantly, declines were steepest at near-ambient pH, suggesting that CCA may have already declined in abundance due to the recent seawater pH decline of 0.1 units and that future severe losses are likely with increasing ocean acidification.
Tumor microenvironment in focus: LA-ICP-MS bioimaging of a preclinical tumor model upon treatment with platinum(iv)-based anticancer agents
Authors: Theiner Sarah , Kornauth Christoph , Varbanov Hristo P , Galanski Mathea S , Van Schoonhoven Sushilla , Heffeter Petra , Berger Walter , Egger Alexander E , Keppler Bernhard K 
Published: March 2015

Abstract
The selection of drug candidates for entering clinical development relies on in vivo testing in (solid) tumor animal models. However, the heterogeneity of tumor tissue (e.g. in terms of drug uptake or tissue composition) is rarely considered when testing novel drug candidates. Therefore, we used the murine colon cancer CT-26 tumor model to study the spatially-resolved drug distribution in tumor tissue upon repetitive treatment of animals over two weeks with three investigational platinum(iv)-based anticancer agents, oxaliplatin or satraplatin. A quantitative laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) imaging method revealed a heterogeneous platinum distribution, which correlated well with the histologic features of the tumor and surrounding tissue at the microscopic level. In most of the cases, higher amounts of intratumoral platinum were found in the surrounding tissue than in the malignant parts of the sample. This indicates that determination of average platinum amounts (e.g. by microwave-assisted digestion of the sample followed by analysis with ICP-MS) might overestimate the drug uptake in tumor tissue causing misleading conclusions. In addition, we studied the platinum distribution in the kidneys of treated animals to probe if accumulation in the cortex and medulla predict potential nephrotoxicity. A 10-fold increase of platinum in the cortex of the kidney over the medulla was observed for oxaliplatin and satraplatin. Although these findings are similar to those in the platinum distribution of the nephrotoxic anticancer drug cisplatin, treatment with the compounds of our study did not show signs of nephrotoxicity in clinical use or clinical trials (oxaliplatin, satraplatin) and did not result in the alteration of renal structures. Thus, predicting the side effects based on bioimaging data by LA-ICP-MS should be considered with caution. To the best of our knowledge, this is the first LA-ICP-MS study on spatially-resolved platinum accumulation in tissues after repetitive platinum-based anticancer drug treatment of mice bearing a preclinical tumor model.
What's on Your Mind? Conversation Topics Chosen by People With Degenerative Cognitive-Linguistic Disorders for Communication Boards
Authors: Fried-Oken Melanie , Daniels Darlene , Ettinger Olivia , Mooney Aimee , Noethe Glory , Rowland Charity 
Published: April 2015

PurposeConversational topics chosen by a group of adults with degenerative cognitive-linguistic disorders for personalized communication board development were examined. The patient-generated themes commonly selected are presented to guide treatment planning and communication board development.MethodCommunication boards were created for 109 adults as part of a larger research project. One autobiographical topic that each participant would enjoy discussing multiple times was represented on each communication board with 16 pictures and word labels. For this review, topics were collapsed into general themes through a consensus process and examined by gender and age.ResultsSixty unique conversational topics were identified from 109 participants and collapsed into 9 general themes: Hobbies, Family, Travel, Work, Home/Places I've Lived, Sports/Fitness, Religion, Animals, and World War II. Age and gender produced variations in themes chosen, though no significance in rank orders was found across groups.ConclusionsTopics selected by adults with degenerative cognitive-linguistic disorders for communication boards resemble common conversational adult themes and do not center around basic needs or medical issues. Differences in gender and age for topic selection tend to be based on traditional roles. These general themes should be used when creating personalized communication boards for those who benefit from conversational aids.
Compact and high‐selectivity microstrip bandpass filter using two‐stage twist‐modified asymmetric split‐ring resonators
Authors: Li Jian , Huang Yongjun , Wen Guangjun , Xue Xiaolin , Song Jiaming 
Published: April 2015

A compact and high frequency selectivity two‐stage microstrip bandpass filter is designed and experimentally demonstrated. Such a kind of filter is composed of two pairs of twist‐modified asymmetric split‐ring resonators (SRRs) to achieve three transmission poles within the passband and four transmission zeros at low and high rejection bands. Sharply out‐of‐band reductions contributing to the high frequency selectivity are obtained by properly detuning the gaps among the SRRs. The measured results show that the proposed filter with dimensions of 0.088 × 0.088λ2 has a 3 dB passband of 15.2% centred at 1.98 GHz. This filter can be flexibly integrated in miniaturised radio‐frequency/microwave circuits.
Pentacene organic thin‐film transistor with HfYO gate dielectric made on adhesive vacuum tape
Authors: Han C.Y. , Tang W.M. , Leung C.H. , Lai P.T. 
Published: April 2015

Pentacene organic thin‐film transistor (OTFT) with HfYO as gate dielectric has been fabricated at room temperature on adhesive flexible vacuum tape and shows high performance. The threshold voltage is as low as −1.77 V due to the high‐κ gate dielectric employed. A small sub‐threshold swing (SS) of 0.145 V/dec indicates good interface between the gate dielectric and pentacene film. Atomic force microscopy (AFM) reveals that large pentacene gains form on the HfYO gate dielectric, leading to a high carrier mobility of 0.236 cm2V−1s−1. These good results suggest that the adhesive vacuum tape can be used as the substrate for adhesive flexible OTFT, and HfYO is a promising gate dielectric for high‐performance pentacene OTFT.
Slotted ground microstrip antenna with FSS reflector for high‐gain horizontal polarisation
Authors: Ram Krishna R.V.S. , Kumar R. 
Published: March 2015

The design of a high‐gain horizontally polarised antenna for ultra‐wideband (UWB) operation is presented and experimentally demonstrated. Gain enhancement is achieved by using a frequency selective surface (FSS) reflector. Both the antenna and the FSS have simple structures and are printed on a similar substrate. The antenna is a three‐stepped narrow rectangular slot excited using a three‐stepped microstrip feed line. By optimising the lengths and widths of the sections of the slot and the feed line, an ultra‐wide impedance bandwidth (3.2–12 GHz, measured) has been achieved. The FSS is a two‐layer structure where each layer is an array of rectangular patches printed on one side of the substrate. With the application of the FSS, the antenna gain is enhanced by 3–4 dBi over most of the band. The polarisation purity (in terms of the measured cross‐polar difference) is also improved with the FSS. Such an antenna–FSS combination will be useful for high‐gain UWB applications requiring horizontal polarisation.
Development of a multi-epitope antigen of S protein-based ELISA for antibodies detection against infectious bronchitis virus
Authors: Ding Meng-die , Wang Hong-ning , Cao Hai-peng , Fan Wen-qiao , Ma Bing-cun , Xu Peng-wei , Zhang An-yun , Yang Xin 
Published: April 2015

AbstractAn indirect enzyme-linked immunosorbent assay (ELISA) method based on a novel multi-epitope antigen of S protein (SE) was developed for antibodies detection against infectious bronchitis virus (IBV). The multi-epitope antigen SE protein was designed by arranging three S gene fragments (166–247 aa, S1 gene; 501–515 aa, S1 gene; 8–30 aa, S2 gene) in tandem. It was identified to be approximately 32 kDa as a His-tagged fusion protein and can bind IBV positive serum by western blot analysis. The conditions of the SE-ELISA method were optimized. The optimal concentration of the coating antigen SE was 3.689 μg/mL and the dilution of the primary antibodies was identified as 1:1000 using a checkerboard titration. The cut-off OD450 value was established at 0.332. The relative sensitivity and specificity between the SE-ELISA and IDEXX ELISA kit were 92.38 and 89.83%, respectively, with an accuracy of 91.46%. This assay is sensitive and specific for detection of antibodies against IBV.
Use of Copepods during Early Feeding Stages of Spotted Rose Snapper Larvae in a Scale-Up System
Authors: Puello-Cruz Ana C , Flores-Rojas Aldo A , Almazán-Rueda Pablo , García-Ortega Armando 
Published: April 2015

Abstract
Growth but not survival of Spotted Rose Snapper Lutjanus guttatus larvae was improved when calanoid copepods Pseudodiaptomus euryhalinus were included as early feed in a pilot-scale production system. Production of P. euryhalinus that were fed microalgae Nannochloropsis oculata was stable through the snapper spawning season (May–September; 21.4–29.5°C), providing 6,200–9,400 copepods/L with higher nutritional quality than rotifers Brachionus rotundiformis. To evaluate the influence of including P. euryhalinus as a first feed, three dietary treatments were administered to larvae from 3 to 15 d posthatch: (1) P. euryhalinus only, (2) a mix of both P. euryhalinus and B. rotundiformis, and (3) B. rotundiformis only. Use of P. euryhalinus as live feed produced significant differences in larval specific growth rate, which was 48.4% of body weight (BW)/d for treatment 1; 17.5% BW/d for treatment 2; and 7.3% BW/d for treatment 3. However, survival was significantly higher for Spotted Rose Snapper larvae that received B. rotundiformis as feed; survival was 5.2% for treatment 3, whereas it was 2.2% for treatment 2 and 1.4% for treatment 1. Larvae that were given P. euryhalinus as feed also had better biochemical content than larvae that were fed only B. rotundiformis.
Motor imagery and cortico‐spinal excitability: A review
Authors: Grosprêtre Sidney , Ruffino Célia , Lebon Florent 
Published: April 2015

AbstractMotor imagery (MI) has received a lot of interest during the last decades as its chronic or acute use has demonstrated several effects on improving sport performances or skills. The development of neuroimagery techniques also helped further our understanding of the neural correlates underlying MI. While some authors showed that MI, motor execution and action observation activated similar motor cortical regions, transcranial magnetic stimulation (TMS) studies brought great insights on the role of the primary motor cortex and on the activation of the cortico‐spinal pathway during MI. After defining MI and describing the TMS technique, a short report of MI activities only at cortical level is provided. Then, a main focus on the specificities of cortico‐spinal modulations during MI, investigated by TMS, is provided. Finally, a brief overview of sub‐cortical mechanisms gives importance to the activation of peripheral neural structures during MI.
Convergence to equilibrium for the damped semilinear wave equation with critical exponent and dissipative boundary condition
Authors: Wu Hao , Zheng Songmu 
Published: April 2015

This paper is concerned with the asymptotic behavior of the solution to the following damped semilinear wave equation with critical exponent:

u

t
t

+

u
t

−
Δ
u
+
f
(
x
,
u
)
=
0
,

(
x
,
t
)
∈
Ω
×

R

+

\begin{equation} u_{tt} + u_t -\Delta u + f(x,u) = 0, \qquad (x,t) \in \Omega \times \mathbb {R}^+ \end{equation}

subject to the dissipative boundary condition

∂
ν

u
+
u
+

u
t

=
0
,

t
>
0
,

x
∈
Γ

\begin{equation} \partial _\nu u+ u + u_t = 0, \qquad t > 0, \ x \in \Gamma \end{equation}

and the initial conditions

u

|

t
=
0

=

u
0

(
x
)
,

u
t

|

t
=
0

=

u
1

(
x
)
,

x
∈
Ω
,

\begin{equation} u|_{t=0} = u_0(x),\quad u_t|_{t=0}=u_1(x), \qquad x \in \Omega , \end{equation}

where

Ω
\Omega

is a bounded domain in

R

3

\mathbb {R}^3

with smooth boundary

Γ
\Gamma

,

ν
\nu

is the outward normal direction to the boundary, and

f
f

is analytic in

u
u

. In this paper convergence of the solution to an equilibrium as time goes to infinity is proved. While these types of results are known for the damped semilinear wave equation with interior dissipation and Dirichlet boundary condition, this is, to our knowledge, the first result with dissipative boundary condition and critical growth exponent.
A blow-up criterion for a degenerate parabolic problem due to a concentrated nonlinear source
Authors: Chan C. , Boonklurb R. 
Published: April 2015

Let

q
q

,

a
a

,

b
b

, and

T
T

be real numbers with

q
≥
0

q\geq 0

,

a
>
0

a>0

,

0
>
b
>
1

0>b>1

, and

T
>
0

T>0

. This article studies the following degenerate semilinear parabolic first initial-boundary value problem,

x

q

u

t

(
x
,
t
)
−

u

x
x

(
x
,
t
)
=
a
δ
(
x
−
b
)
f

(
u
(
x
,
t
)
)

for
0
>
x
>
1
,

0
>
t
≤
T
,

u
(
x
,
0
)
=
ψ
(
x
)
for
0
≤
x
≤
1
,
u
(
0
,
t
)
=
u
(
1
,
t
)
=
0
for
0
>
t
≤
T
,

\begin{gather*} x^{q}u_{t}(x,t)-u_{xx}(x,t)=a\delta (x-b)f\left ( u(x,t)\right ) \text { for }0>x>1,\text { }0>t\leq T,\\ u(x,0)=\psi (x)\text { for }0\leq x\leq 1\text {, }u(0,t)=u(1,t)=0\text { for }0>t\leq T, \end{gather*}

where

δ

(
x
)

\delta \left ( x\right )

is the Dirac delta function, and

f
f

and

ψ
\psi

are given functions. It is shown that for

a
a

sufficiently large, there exists a unique number

b

∗

∈

(
0
,
1

/

2
)

b^{\ast }\in \left ( 0,1/2\right )

such that

u
u

never blows up for

b
∈

(
0
,

b

∗

]

∪

[
1
−

b

∗

,
1
)

b\in \left ( 0,b^{\ast }\right ] \cup \left [ 1-b^{\ast },1\right )

, and

u
u

always blows up in a finite time for

b
∈
(

b

∗

,
1
−

b

∗

)

b\in (b^{\ast },1-b^{\ast })

. To illustrate our main results, two examples are given.
Overlap and diversity in antimicrobial peptide databases: compiling a non-redundant set of sequences
Authors: Aguilera-Mendoza Longendri , Marrero-Ponce Yovani , Tellez-Ibarra Roberto , Llorente-Quesada Monica T. , Salgado Jesús , Barigye Stephen J. , Liu Jun 
Published: March 2015

Abstract
Motivation: The large variety of antimicrobial peptide (AMP) databases developed to date are characterized by a substantial overlap of data and similarity of sequences. Our goals are to analyze the levels of redundancy for all available AMP databases and use this information to build a new non-redundant sequence database. For this purpose, a new software tool is introduced.
Results: A comparative study of 25 AMP databases reveals the overlap and diversity among them and the internal diversity within each database. The overlap analysis shows that only one database (Peptaibol) contains exclusive data, not present in any other, whereas all sequences in the LAMP_Patent database are included in CAMP_Patent. However, the majority of databases have their own set of unique sequences, as well as some overlap with other databases. The complete set of non-duplicate sequences comprises 16 990 cases, which is almost half of the total number of reported peptides. On the other hand, the diversity analysis identifies the most and least diverse databases and proves that all databases exhibit some level of redundancy. Finally, we present a new parallel-free software, named Dover Analyzer, developed to compute the overlap and diversity between any number of databases and compile a set of non-redundant sequences. These results are useful for selecting or building a suitable representative set of AMPs, according to specific needs.
Availability and implementation: The regularly updated non-redundant sequence databases and the Dover Analyzer software to perform custom analysis are available at http://mobiosd-hub.com/doveranalyzer/.
Contact: ymarrero77@yahoo.es
Supplementary information: Supplementary data are available at Bioinformatics online.
Recommendations to improve the usability of drug-drug interaction clinical decision support alerts
Authors: Payne Thomas H , Hines Lisa E. , Chan Raymond C , Hartman Seth , Kapusnik-Uner Joan , Russ Alissa L , Chaffee Bruce W , Hartman Christian , Tamis Victoria , Galbreth Brian , Glassman Peter A , Phansalkar Shobha , van der Sijs Heleen , Gephart Sheila M , Mann Gordon , Strasberg Howard R , Grizzle Amy J , Brown Mary , Kuperman Gilad J , Steiner Chris , Sullins Amanda , Ryan Hugh , Wittie Michael A , Malone Daniel C 
Published: April 2015

Abstract
Objective: To establish preferred strategies for presenting drug-drug interaction (DDI) clinical decision support alerts.
Materials and Methods: A DDI Clinical Decision Support Conference Series included a workgroup consisting of 24 clinical, usability, and informatics experts representing academia, health information technology (IT) vendors, healthcare organizations, and the Office of the National Coordinator for Health IT. Workgroup members met via web-based meetings 12 times from January 2013 to February 2014, and two in-person meetings to reach consensus on recommendations to improve decision support for DDIs. We addressed three key questions: (1) what, how, where, and when do we display DDI decision support? (2) should presentation of DDI decision support vary by clinicians? and (3) how should effectiveness of DDI decision support be measured?
Results: Our recommendations include the consistent use of terminology, visual cues, minimal text, formatting, content, and reporting standards to facilitate usability. All clinicians involved in the medication use process should be able to view DDI alerts and actions by other clinicians. Override rates are common but may not be a good measure of effectiveness.
Discussion: Seven core elements should be included with DDI decision support. DDI information should be presented to all clinicians. Finally, in their current form, override rates have limited capability to evaluate alert effectiveness.
Conclusion: DDI clinical decision support alerts need major improvements. We provide recommendations for healthcare organizations and IT vendors to improve the clinician interface of DDI alerts, with the aim of reducing alert fatigue and improving patient safety.
Comparison of consumers’ views on electronic data sharing for healthcare and research
Authors: Kim Katherine K , Joseph Jill G , Ohno-Machado Lucila 
Published: April 2015

Abstract
New models of healthcare delivery such as accountable care organizations and patient-centered medical homes seek to improve quality, access, and cost. They rely on a robust, secure technology infrastructure provided by health information exchanges (HIEs) and distributed research networks and the willingness of patients to share their data. There are few large, in-depth studies of US consumers’ views on privacy, security, and consent in electronic data sharing for healthcare and research together.
Objective This paper addresses this gap, reporting on a survey which asks about California consumers’ views of data sharing for healthcare and research together.
Materials and Methods The survey conducted was a representative, random-digit dial telephone survey of 800 Californians, performed in Spanish and English.
Results There is a great deal of concern that HIEs will worsen privacy (40.3%) and security (42.5%). Consumers are in favor of electronic data sharing but elements of transparency are important: individual control, who has access, and the purpose for use of data. Respondents were more likely to agree to share deidentified information for research than to share identified information for healthcare (76.2% vs 57.3%, p &lt; .001).
Discussion While consumers show willingness to share health information electronically, they value individual control and privacy. Responsiveness to these needs, rather than mere reliance on Health Insurance Portability and Accountability Act (HIPAA), may improve support of data networks.
Conclusion Responsiveness to the public’s concerns regarding their health information is a pre-requisite for patient-centeredness. This is one of the first in-depth studies of attitudes about electronic data sharing that compares attitudes of the same individual towards healthcare and research.
Six cases of silicosis: implications for health surveillance of stonemasons
Authors: Nicol L. M. , McFarlane P. A. , Hirani N. , Reid P. T. 
Published: March 2015

Abstract

Background
Silicosis is one of the oldest occupational lung diseases, but it continues to cause significant morbidity and mortality worldwide.

Aims
To report cases of silicosis presenting to two specialist respiratory clinics.

Methods
A retrospective analysis of prospectively collected data of cases of silicosis in workers referred to specialist respiratory clinics.

Results
Over the course of 6 years, six cases were identified. The patients were all male with an age range between 24 and 39 years. The duration of silica exposure ranged between 7 and 20 years (mean 13 years). Four cases were entirely asymptomatic at presentation, and two cases described minimal shortness of breath on exertion. Pulmonary function tests were normal in three cases, and a mild restrictive ventilatory defect was documented in the other cases. All had a low apparent predicted probability of pneumoconiosis based on health questionnaires, spirometry and duration of silica exposure. The initial chest X-ray was abnormal in all six cases with radiological evidence of silicosis (International Labour Office profusion category ≥1/1) on imaging, and all had evidence of silicosis on high-resolution computed tomography (HRCT). Three patients had already progressed to progressive massive fibrosis on HRCT scanning at the time of referral to specialist respiratory services.

Conclusions
The appearances of these six cases of silicosis in young, asymptomatic construction workers emphasizes the importance of enforcing effective exposure control and comprehensive surveillance programmes. Our observations highlight the importance of having a low threshold for early radiological screening to promote early and effective detection of this disease.