bluuebunny/crossref_metadata_2025_split huggingface dataset:
Measuring misclassification and sample bias in passive surveillance systems: Improving prevalence estimates of critical congenital heart defects in state‐based passive surveillance systems
Authors: Barnett Chris , Christiansen James , Mills Monica , Lord Jordyn , Parrish Jared 
Published: August 2024

AbstractObjectivesWe assessed reporting misclassification for 12 critical congenital heart defects (CCHDs) identified through administrative diagnosis codes within a passive surveillance system. We measured the effect of misclassification on prevalence estimation. Lastly, we investigated a sample‐based review strategy to estimate surveillance misclassification resulting from administrative diagnosis codes for case detection.MethodsWe received 419 reports of CCHDs between 2007 and 2018; 414 were clinically reviewed. We calculated confirmation probabilities to assess misclassification and adjust prevalence estimates. Random samples of reported cases were taken at proportions between 20% and 90% for each condition to assess sample bias. Sampling was repeated 1000 times to measure sample‐estimate variability.ResultsMisclassification ranged from a low of 19% (n = 4/21) to a high of 84% (n = 21/25). Unconfirmed prevalence rates ranged between one and six cases per 10,000 live births, with some conditions significantly higher than national estimates. However, confirmed rates were either lower or comparable to national estimates.ConclusionPassive birth defect surveillance programs that rely on administrative diagnosis codes for case identification of CCHDs are subject to misclassification that bias prevalence estimates. We showed that a sample‐based review could improve the prevalence estimates of 12 cardiovascular conditions relative to their unconfirmed prevalence rates.
Transient Photoactivation of Anionophores by Using Redshifted Fast‐Relaxing Azobenzenes
Authors: Kerckhoffs Aidan , Ahmad Manzoor , Langton Matthew J. 
Published: August 2024

AbstractPhoto‐regulated transmembrane ionophores enable spatial and temporal control over activity, offering promise as targeted therapeutics. Key to such applications is control using bio‐compatible visible light. Herein, we report red‐shifted azobenzene‐derived synthetic anionophores that use amber or red light to trigger (E)‐(Z) photoisomerisation and activation of transmembrane chloride transport. We demonstrate that by tuning the thermal half‐life of the more active, but thermodynamically unstable, Z isomer to relax on the timescale of minutes, transient activation of ion transport can be achieved by activating solely with visible light and deactivating by thermal relaxation.
Chameleonic Cages: Encapsulation of Anionic, Neutral, and Cationic Guest Species within [Fe4L4]8+ Tetrahedral Cages Synthesised from the tris(4‐aminophenyl)phosphate pro‐Ligand
Authors: Ward Jas S. , Kruger Paul E. 
Published: August 2024

AbstractAn adaptable Fe(II) tetrahedral cage, [Fe4L4][BF4]8 (L=tris(4‐(((E)‐pyridin‐2‐ylmethylene)amino)phenyl) phosphate), has been synthesised via self‐assembly. By modulating the orientation of its pendant P=O groups, the cage was found to be capable of encapsulating anionic, neutral, and cationic guests, which were confirmed in the solid state via single‐crystal X‐ray diffraction (SCXRD) and in solution by high‐resolution mass spectroscopy (HR‐MS), as well as by NMR (1H, 19F, 31P) studies where possible.
Small‐Molecular Donor Based Efficient Organic Solar Cells with Thermally Stable Morphologies†
Authors: Feng Wanying , Bai Yuyang , Wang Jiaying , Yuan Shaohui , Wan Xiangjian , Chen Yu , Kan Bin , Chen Yongsheng 
Published: August 2024

Comprehensive SummarySmall‐molecular organic solar cells usually exhibited unsatisfactory device stability, which might originate from their molecular diffusion behaviors. Herein, based on the all‐small‐molecule system HD‐1:BTP‐eC9, we reported a dimerized acceptor DC9, and its corresponding monomer acceptor eOD. In comparison with eOD, the dimeric acceptor DC9 displayed higher glass transition temperature (Tg) but reduced molecular planarity and crystallinity. The all‐small molecule blend utilizing HD‐1:eOD demonstrated a power conversion efficiency (PCE) of 15.13%, surpassing the value of 14.10% for the HD‐1:DC9 blend. While, incorporating polymer donor PM6 into the HD‐1:DC9 blend improved its morphology and charge transport dynamics, resulting in a device efficiency of over 16%, representing the rare case utilizing small‐molecular donor and dimeric acceptor with PCE over 16%. Morphological characterization results affirmed that the surface morphologies and molecular packing behaviors of the blend films based on HD‐1 were largely retained even after prolonged annealing and aging at 85 °C. Consequently, the PCEs of the blend films based on HD‐1:eOD, HD‐1:DC9, and HD‐1:PM6:DC9 consistently remained over 98% of their initial efficiency after 1000 h of thermal annealing aging at 85 °C. These findings highlight the potential of small‐molecular based active layer in the fabrication of efficient and stable OSCs.
Atmospheric Pressure Plasma Functionalization of Sealed PDMS Microfluidics: Application to Capillary Pumping and Enhanced Cell Growth
Authors: Zeniou A. , Kefallinou D. , Dimitrakellis P. , Xenogiannopoulou E. , Grigoriou M. , Dimoulas A. , Boumpas D. T. , Tserepi A. , Gogolides E. 
Published: August 2024

AbstractMicrofluidic devices serve as essential tools across diverse fields like medicine, biotechnology, and chemistry, enabling advancements in analytical techniques, point‐of‐care diagnostics, microfluidic cell cultures, and organ‐on‐chip models. While polymeric microfluidics are favoured for their cost‐effectiveness and ease of fabrication, their inherent hydrophobic properties necessitate surface functionalization, often post‐sealing. Here, we introduce a versatile apparatus for functionalizing sealed microfluidic devices using atmospheric plasma processing, with a focus on PDMS (polydimethylsiloxane) microfluidics. Through meticulous analysis of surface properties and capillary speed, before and after plasma treatment, along with a comparison between vacuum and atmospheric plasma functionalization methods, we demonstrate the efficacy of our approach. Subsequent experimentation within 3D PDMS microfluidic chambers, combining atmospheric pressure plasma treatment with collagen coating to facilitate mesenchymal stem cells (MSCs) growth over five days, reveals enhanced initial cell adhesion and proliferation, highlighting the potential of our method for improving cell‐based applications within microfluidic systems.
Patient's Experiences of a Cognitive Behaviour Therapy Informed Crisis Intervention for Psychosis Delivered in Inpatient Settings: A Qualitative Exploration
Authors: Wood Lisa , Butterworth Hannah , Nyikavaranda Patrick , Ariyo Aderayo , Malde‐Shah Nira , Guerin Ella , Birken Mary , Persaud Karen , Dare Ceri , Morant Nicola , Johnson Sonia 
Published: August 2024

ABSTRACTCognitive behaviour therapy for psychosis (CBTp) should be offered to patients receiving psychiatric inpatient care, yet very little is known about patients' perspectives on this. The aim of this study was to examine patients' experiences of a CBTp‐informed intervention delivered in inpatient settings. We recruited 10 participants from the intervention arm of a randomised controlled trial examining the feasibility and acceptability of a CBTp‐informed intervention for psychiatric inpatient settings. We undertook semistructured interviews examining their experiences of the intervention and analysed them using thematic analysis. The study was conducted in partnership with a coproduction group of key stakeholders (people with lived experience, family and carers, and clinicians). The intervention was found helpful by almost all participants, and all participants would recommend it to others in similar situations to themselves. The results demonstrated that participants valued the therapist's professionalism and emphasised the importance of the therapeutic relationship. Participants highlighted the importance of the therapy focusing on navigating admission and developing skills to manage the crisis experience so they could return to their normal lives. Participants described challenges to having psychological therapy in the acute crisis context including therapy interruptions and ongoing distressing experiences of psychosis. The study demonstrated the importance of prioritising the therapeutic relationship, that therapy was a valued process to navigate admission and discharge, but that some environmental and patient‐level challenges were present. Further research is needed to explore inpatients' experiences of psychological interventions in this setting.Trial RegistrationISRCTN trial registry: ISRCTN59055607
Asymmetric π‐Extension Design of Long Wavelength Rhodamine Derivatives for Imaging and Phototherapy
Authors: He Long , Huang Jing , Zhang Xingxing , Ren Tianbing , Yuan Lin 
Published: August 2024

AbstractRhodamine dyes have been extensively explored for bioimaging and therapeutic applications over the past few decades. However, it remains a challenge to design long‐wavelength and large Stokes shift rhodamine derivatives to meet the requirements of fluorescence imaging and phototherapy in deep living tissues. In this work, a pyridine aromatic unit was inserted into the rhodamine derivatives (AC‐Fluor: ACF) skeleton to prepare a series of stable rhodamine derivatives, named ACFPs, to achieve long emission wavelength (>650 nm) and large Stokes shift (~60 nm) by tuning the conjugated systems and electronic symmetry. Moreover, ACFPs are capable of continuously producing superoxide radical (O2−⋅) under long wavelength irradiation. This study presents a novel paradigm for improving the optical properties of rhodamine, which has led to the development of a novel tool for image‐guided phototherapy for cancer treatment.
Bilevel access control and constraint‐aware response provisioning in edge‐enabled software defined network‐internet of things network using the safeguard authentication dynamic access control model
Authors: D S Sahana , S H Brahmananda 
Published: August 2024

SummaryBy controlling the network, the Internet of Things (IoT)‐connected software‐defined network (SDN) limits the scalability of IoT devices. Since SDN depends on a centralized controller that attackers can easily affect, it is incredibly susceptible to attacks. Secure access control to the SDN controller was the focus of the prior methods for controller scalability and restricted trust management. A framework called Safeguard Authentication Dynamic Access Control (SANDMAC) is suggested to safeguard and offer useful services to enterprises. Authentication confirms legitimacy after all users and applications have been registered. To improve network security, policies let users grant access to account attributes, legal activities, and temporal components. The administrator lessens conflicts between the methods by validating and saving the policies in the database. The services are provided to dependable customers using the forensic‐based investigation algorithm, depending on the quality of service and software level agreements requirements, decreasing reaction times and maximizing resource usage. Performance comparisons between the new and previous efforts are validated using a variety of parameters, and the proposed work is validated using the iFogSim application. According to the findings, SANDMAC significantly raises key performance indicators. SANDMAC specifically keeps false positives at 3.5% and accomplishes a low response time of 60 ms for roughly 800 authorized accesses. SANDMAC is a better option because of these enhancements, which result in longer network lifetimes and more dependable data transmission.
Characterizing atrial fibrillation in patients with and without heart failure across the ejection fraction spectrum: Incidence, prevalence, and treatment strategies
Authors: Valente Valeria , Ferrannini Giulia , Benson Lina , Gatti Paolo , Guidetti Federica , Melin Michael , Braunschweig Frieder , Linde Cecilia , Dahlström Ulf , Lund Lars H. , Fudim Marat , Savarese Gianluigi 
Published: August 2024

AbstractAimsHeart failure (HF) and atrial fibrillation (AF) often coexist. We explored AF incidence, prevalence, and treatment strategies in patients with versus without HF across the ejection fraction (EF) spectrum.Methods and resultsWe analysed patients with HF from the Swedish HF Registry (1 December 2005–31 December 2021), matched 1:1 by sex, age, and county of residence to patients without HF from Statistics Sweden. Two study cohorts were derived (i) to assess AF prevalence and treatments, and (ii) to evaluate AF incidence and related predictors. Overall, 195 106 patients were considered, 50% of them with HF (of whom 54% with HF with reduced [HFrEF], 23% mildly reduced [HFmrEF], and 23% with preserved EF [HFpEF]). From 2006 to 2021, AF prevalence increased in both patients with (57% to 58%) and without HF (8% to 11%). HF patients, particularly if with HFrEF, were more likely receiving AF treatments than those without HF. Over time, antiarrhythmic use decreased, while rate control drugs and oral anticoagulant use, and AF‐related procedures increased, regardless of HF and EF. During a median follow‐up of 3.7 years, in 86 210 patients without AF, incident AF risk was two‐fold higher in HF versus non‐HF (hazard ratio [HR] 2.76, 95% confidence interval [CI] 2.45–3.12), highest in HFpEF (HR 3.12, 95% CI 2.65–3.67) versus HFrEF (HR 2.68, 95% CI 2.34–3.06) and HFmrEF (HR 2.53, 95% CI 2.17–2.94).ConclusionsAtrial fibrillation prevalence, anticoagulant use, and AF‐related procedures increased over time regardless of HF, with HF patients more likely receiving AF treatments. In HF, despite higher AF prevalence and incidence in HFpEF, AF treatment use remained modest, calling for further implementation.
The intra‐ and interrater reliability of isometric muscle contractions using a novel fixation system for a hand‐held dynamometer
Authors: Schindler Jessica B. , Hancock Clifford L. , Zifchock Rebecca A. , Bode Victoria G. , Ramsay John W. 
Published: August 2024

AbstractA novel fixation system for a hand‐held dynamometer (HHD) was designed to enable isometric muscle measurements on various muscle groups of strong, healthy individuals in a field setting. The objective of this study was to evaluate the intra‐ and interrater reliability of the system and determine its suitability for use by multiple researchers within large‐scale data collections during field activities. Four researchers tested eight healthy subjects, who each completed eight different maximal isometric muscle strength assessments using the HHD fixation system. Intraclass correlation coefficients (ICC) results were evaluated with a 95% confidence interval. ICC results for interrater reliability demonstrated excellent agreement of all eight measurements tested. ICC results for intrarater reliability demonstrated excellent agreement for six out of eight measurements. This system provides a new opportunity for several different high‐quality maximal muscle strength measurements to be collected by multiple data collectors on large numbers of strong, healthy individuals in a field setting.
Integrating foresight and evaluation: The example of ParEvo
Authors: Davies Rick J. 
Published: August 2024

AbstractThis paper aims to encourage connections between the fields of program evaluation and foresight practice by describing the use of a web application ParEvo as an example of how foresight methods can incorporate evaluative thinking. It begins by introducing the field of foresight practice, along with its differences and commonalities with that of evaluation. It then introduces ParEvo.org and its uses to date, along with a detailed description of how a ParEvo exercise is implemented. An overview is also given of how different types of evaluation activities are built throughout the implementation process. Attention is then focused on three different types of embedded theories of change, and how they can be evaluated. The paper concludes with two observations about the breadth and depth of evaluative thinking present in ParEvo processes and the supporting platform. Some limitations are also acknowledged, arising from the rich nature of the outputs generated and the decentralized nature of the design and operation of ParEvo exercises.
Multidimensional challenges of internationalization among universities in Southeast Asia: A scoping review of empirical evidence
Authors: Kanmodi Kehinde Kazeem , Salami Afeez Abolarinwa , Amzat Jimoh 
Published: August 2024

AbstractInternationalization plays a crucial role in building the international competitiveness and profile of a university. However, the process of internationalization can be very challenging. The understanding of these challenges is very crucial for internationalization implementation and improvement. This scoping review aimed to map the existing empirical evidence on the peculiar challenges of internationalization among universities in Southeast Asia. This scoping review was conducted based on Arksey and O’Malley's methodological framework and it was reported using the PRISMA‐ScR checklist. Ten research databases were systematically searched to retrieve all literature relevant to the review question. The retrieved articles were deduplicated and screened based on the review's eligibility criteria, and only the eligible articles were included in the review. Thereafter, relevant data were charted, collated, and summarized from the included literature and presented as results. A total of 34 articles were included in this review. Most of them were qualitative studies (26/34) and from studies conducted in Malaysia (21/34). The reported internationalization challenges in these articles were multidimensional and ranged from the individual to governmental level; however, the most reported challenges were the ones at the individual level which include issues related to adjustment/coping, trust, limited personal resources, family, and essential survival needs. There are numerous challenges facing the implementation of internationalization among universities in Southeast Asia. More efforts need to be placed at all levels to improve the status quo.
Wood and Mint Aroma Interactions During Spirit Oak Cask Maturation: A Sensory Case Study
Authors: Nhouchi Zeineb , Lafleur Cassandre , Chalut Pauline , Vallet Nadine , Vivas Nicolas , Vivas Nathalie , Picard Magali 
Published: August 2024

ABSTRACTThe aroma of fine matured spirits is typically complex, resulting from numerous reactions occurring during the production process and some developing during maturation in oak casks. The refreshing sensation brought by mint notes was often expected, even after years of maturation. The main challenge lies in achieving an aromatic balance characterised by the seamless integration of woody aromas while maintaining the initial distillate's freshness. The present study examines the sensory effects associated with the interactions between wood, mint and cold sensations in spirits. Nine spirit model solutions were prepared, representing different combinations of terpene ketones (imparting mint aroma) and wood compounds, each at three concentration levels. The quantitative composition of mint compounds simulated varying degrees of mintiness in the distillate (low, medium and high), while the concentrations of wood compounds mimicked three maturation periods (short, intermediate and long term) in wooden casks. Samples were sensorily analysed by discriminative (triangle test) and rate‐all‐that‐apply (RATA) methodologies. An increase in woody intensity was notably perceived in samples with a low‐mint profile and containing wood compounds associated with medium and long‐term maturation. However, no significant sensory differences were observed in mint and cold perception between model solutions regardless of the simulated maturation conditions, indicating a limited influence of the studied wood compounds on the sensation of freshness in spirits due to competitive perceptual interactions with terpene ketones.
Anticancer potential of decursin, decursinol angelate, and decursinol from Angelica gigas Nakai: A comprehensive review and future therapeutic prospects
Authors: Sestito Simona , Ibba Roberta , Riu Federico , Carpi Sara , Carta Antonio , Manera Clementina , Habtemariam Solomon , Yeskaliyeva Balakyz , Almarhoon Zainab M. , Sharifi‐Rad Javad , Rapposelli Simona 
Published: August 2024

AbstractMany naturally derived compounds are currently used in oncotherapy. Besides official medicine, complementary and alternative medicine practices, including old herbal remedies, are widely used and accepted as additional tools in cancer treatment. Angelica gigas Nakai (AGN), a medicinal herb in Asia, has roots historically used in medicine. This review focuses on key bioactive compounds from AGN roots – decursin, decursinol angelate (DA), and decursinol (DOH). Exploring their source, biosynthesis, and therapeutic mechanisms, the review highlights their role in cancer treatment. Biotechnological strategies for enhanced production and semisynthetic derivatives with anticancer properties are discussed. The study emphasizes the promising pharmacological potential of decursin, DA, and DOH in various therapeutic applications, particularly cancer treatment. The review also underscores innovative approaches to increase production and explores semisynthetic derivatives as a promising avenue for future natural product‐based drug discovery. This concise overview provides valuable insights into the potential of AGN‐derived compounds in the field of natural product‐based therapeutics.
The role of radiotherapy in the treatment of sinonasal undifferentiated carcinoma: A population‐based analysis
Authors: Zhao Xin , Pei Ziqi , Song Xiang , Jin Gang 
Published: August 2024

AbstractBackgroundSinonasal undifferentiated carcinoma (SNUC) is a rare, aggressive disease with ambiguous management and poor prognosis. This study aimed to evaluate the role of radiation therapy (RT) and explore the optimal treatment sequence.MethodsRetrospective analysis of survival trends of 410 SNUC patients between 1973 and 2015.ResultsThe 5‐year cancer‐specific survival (CSS) rate (45.1%) and overall survival (OS) rates (38.1%) were reported in the 84‐month median follow‐up. Radiotherapy was a prognosticator for improving CSS (hazard ratio [HR] = 0.425, 95% confidence interval [CI]: 0.299–0.603, p = 0.000) and OS (HR = 0.415, 95% CI: 0.303–0.570, p = 0.000), either with surgery (p = 0.000) or without surgery (p = 0.000). However, in a combined therapy of surgery and RT, preoperative and postoperative RT (5‐year OS rates were 47.1% and 45.6%, respectively, p = 0.486) were not significantly different.ConclusionsRadiotherapy plays a key role in improving SNUC survival rates. No significant difference in survival rates was observed in preoperative and postoperative RT treatment.