bluuebunny/crossref_metadata_2025_split huggingface dataset:
Down‐Regulation of Thioredoxin1 Is Involved in Death of Calu‐6 Lung Cancer Cells Treated With Suberoyl Bishydroxamic Acid
Authors: You Bo Ra , Park Woo Hyun 
Published: October 2015

ABSTRACTSuberoyl bishydroxamic acid (SBHA), a histone deacetylase (HDAC) inhibitor, can show an anticancer effect. In this study, we investigated the effects of SBHA on the growth inhibition and death of Calu‐6 and NCI‐H1299 cells in relation to reactive oxygen species (ROS) and antioxidant levels. SBHA inhibited the growth of Calu‐6 and NCI‐H1299 lung cancer cells with an IC50 of 50 µM at 72 h. This agent induced apoptosis in Calu‐6 cells and triggered to a G2/M phase arrest in NCI‐H1299 cells. Although it also reduced the growth of normal human pulmonary fibroblast (HPF) cells, the susceptibility of Calu‐6 cells to SBHA was higher than that of HPF cells. In addition, SBHA did not affect the growth of human small airway epithelial cells (HSAEC). Regarding ROS and antioxidant levels, SBHA increased ROS level and glutathione (GSH) depletion in Calu‐6 and NCI‐H1299 cells whereas it decreased ROS levels in HPF and HSAEC. SBHA also decreased thioredoxin1 (Trx1) level in Calu‐6 cells. Although the down‐regulation of Trx1 intensified apoptosis and ROS level in SBHA‐treated Calu‐6 cells, the overexpression of Trx1 attenuated apoptosis and ROS level in these cells. This down‐regulation of Trx1 did not affect apoptosis‐signaling regulating kinase1 (ASK1) activation. In conclusion, the down‐regulation of Trx1 by SBHA was closely involved in cell death in Calu‐6 cells. J. Cell. Biochem. 117: 1250–1261, 2016. © 2015 Wiley Periodicals, Inc.
Glucose transformation to 5‐hydroxymethylfurfural in acidic ionic liquid: A quantum mechanical study
Authors: Arifin  , Puripat Maneeporn , Yokogawa Daisuke , Parasuk Vudhichai , Irle Stephan 
Published: October 2015

Isomerization and transformation of glucose and fructose to 5‐hydroxymethylfurfural (HMF) in both ionic liquids (ILs) and water has been studied by the reference interaction site model self‐consistent field spatial electron density distribution (RISM‐SCF‐SEDD) method coupled with ab initio electronic structure theory, namely coupled cluster single, double, and perturbative triple excitation (CCSD(T)). Glucose isomerization to fructose has been investigated via cyclic and open chain mechanisms. In water, the calculations support the cyclic mechanism of glucose isomerization; with the predicted activation free energy is 23.8 kcal mol−1 at experimental condition. Conversely, open ring mechanism is more favorable in ILs with the energy barrier is 32.4 kcal mol−1. Moreover, the transformation of fructose into HMF via cyclic mechanism is reasonable; the calculated activation barriers are 16.0 and 21.5 kcal mol−1 in aqueous and ILs solutions, respectively. The solvent effects of ILs could be explained by the decomposition of free energies and radial distribution functions of solute‐solvent that are produced by RISM‐SCF‐SEDD. © 2015 Wiley Periodicals, Inc.
INTEGRATING BEHAVIORAL ECONOMICS AND BEHAVIORAL GENETICS: DELAYED REWARD DISCOUNTING AS AN ENDOPHENOTYPE FOR ADDICTIVE DISORDERS
Authors: MacKillop James 
Published: October 2015

AbstractDelayed reward discounting is a behavioral economic index of impulsivity, referring to how much an individual devalues a reward based on its delay in time. As a behavioral process that varies considerably across individuals, delay discounting has been studied extensively as a model for self‐control, both in the general population and in clinical samples. There is growing interest in genetic influences on discounting and, in particular, the prospect of discounting as an endophenotype for addictive disorders (i.e., a heritable mechanism partially responsible for conferring genetic risk). This review assembles and critiques the evidence supporting this hypothesis. Via numerous cross‐sectional studies and a small number of longitudinal studies, there is considerable evidence that impulsive discounting is associated with addictive behavior and appears to play an etiological role. Moreover, there is increasing evidence from diverse methodologies that impulsive delay discounting is temporally stable, heritable, and that elevated levels are present in nonaffected family members. These findings suggest that impulsive discounting meets the criteria for being considered an endophenotype. In addition, recent findings suggest that genetic variation related to dopamine neurotransmission is significantly associated with variability in discounting preferences. A significant caveat, however, is that the literature is modest in some domains and, in others, not all the findings have been supportive or consistent. In addition, important methodological considerations are necessary in future studies. Taken together, although not definitive, there is accumulating support for the hypothesis of impulsive discounting as an endophenotype for addictive behavior and a need for further systematic investigation.
TOWARDS A GENERAL MODEL OF TEMPORAL DISCOUNTING
Authors: van den Bos Wouter , McClure Samuel M. 
Published: October 2015

AbstractPsychological models of temporal discounting have now successfully displaced classical economic theory due to the simple fact that many common behavior patterns, such as impulsivity, were unexplainable with classic models. However, the now dominant hyperbolic model of discounting is itself becoming increasingly strained. Numerous factors have arisen that alter discount rates with no means to incorporate the different influences into standard hyperbolic models. Furthermore, disparate literatures are emerging that propose theoretical constructs that are seemingly independent of hyperbolic discounting. We argue that, although hyperbolic discounting provides an eminently useful quantitative measure of discounting, it fails as a descriptive psychological model of the cognitive processes that produce intertemporal preferences. Instead, we propose that recent contributions from cognitive neuroscience indicate a path for developing a general model of time discounting. New data suggest a means by which neuroscience‐based theory may both integrate the diverse empirical data on time preferences and merge seemingly disparate theoretical models that impinge on time preferences.
BEHAVIORAL ECONOMICS AND EMPIRICAL PUBLIC POLICY
Authors: Hursh Steven R. , Roma Peter G. 
Published: October 2015

AbstractThe application of economics principles to the analysis of behavior has yielded novel insights on value and choice across contexts ranging from laboratory animal research to clinical populations to national trends of global impact. Recent innovations in demand curve methods provide a credible means of quantitatively comparing qualitatively different reinforcers as well as quantifying the choice relations between concurrently available reinforcers. The potential of the behavioral economic approach to inform public policy is illustrated with examples from basic research, pre‐clinical behavioral pharmacology, and clinical drug abuse research as well as emerging applications to public transportation and social behavior. Behavioral Economics can serve as a broadly applicable conceptual, methodological, and analytical framework for the development and evaluation of empirical public policy.
Evaluation of venous thromboembolism prophylaxis in patients with chronic liver disease
Authors: Smith Carmen B. , Hurdle April C. , Kemp Leonette O. , Sands Christophe , Twilla Jennifer D. 
Published: October 2015

BACKGROUNDThe incidence of venous thromboembolism (VTE) in chronic liver disease (CLD) patients has been reported to be 0.5% to 6.3%. Studies report the use of thromboprophylaxis in CLD patients as suboptimal, with at least 75% of patients receiving no prophylaxis.OBJECTIVETo describe the use of VTE prophylaxis in CLD patients.DESIGNA retrospective review.SETTINGTertiary‐care academic medical center.PATIENTSInpatient admissions from August 2009 through July 2011 with CLD diagnosis.INTERVENTIONNone.MEASUREMENTSInitiation and type of thromboprophylaxis, incidence of VTE, bleeding events, hospital length of stay, in‐hospital mortality, 30‐day readmission for VTE.RESULTSOf the 410 patients included, 225 (55%) patients received thromboprophylaxis. For patients with international normalized ratio (INR) >2.0, a significant decrease in overall thromboprophylaxis use and pharmacologic prophylaxis use was seen compared to those with INR 1.4 to 2.0 (P = 0.013 and P < 0.001, respectively). Overall incidence of VTE was 0.7%. Fifteen bleeding events occurred (3.7%): 9 on mechanical prophylaxis, 1 on pharmacologic, 3 on combination, and 2 with no prophylaxis. The majority of patients experiencing a bleeding event had an INR >2.0 (P = 0.001).CONCLUSIONThe use of thromboprophylaxis in CLD patients is higher in our study than previous reports but remains suboptimal. Use of VTE pharmacologic prophylaxis does not appear to increase bleeding in CLD patients with INR ≤2.0. Further studies are needed to provide additional safety data. Journal of Hospital Medicine 2013;8:569–573. © 2013 Society of Hospital Medicine
One drop chemical derivatization – DESI‐MS analysis for metabolite structure identification
Authors: Lubin Arnaud , Cabooter Deirdre , Augustijns Patrick , Cuyckens Filip 
Published: October 2015

Structural elucidation of metabolites is an important part during the discovery and development process of new pharmaceutical drugs. Liquid Chromatography (LC) in combination with Mass Spectrometry (MS) is usually the technique of choice for structural identification but cannot always provide precise structural identification of the studied metabolite (e.g. site of hydroxylation and site of glucuronidation). In order to identify those metabolites, different approaches are used combined with MS data including nuclear magnetic resonance, hydrogen/deuterium exchange and chemical derivatization followed by LC‐MS. Those techniques are often time‐consuming and/or require extra sample pre‐treatment.In this paper, a fast and easy to set up tool using desorption electrospray ionization–MS for metabolite identification is presented. In the developed method, analytes in solution are simply dried on a glass plate with printed Teflon spots and then a single drop of derivatization mixture is added. Once the spot is dried, the derivatized compound is analyzed. Six classic chemical derivatizations were adjusted to work as a one drop reaction and applied on a list of compounds with relevant functional groups. Subsequently, two successive reactions on a single spot of amoxicillin were tested and the methodology described was successfully applied on an in vitro incubated alprazolam metabolite. All reactions and analyses were performed within an hour and gave useful structural information by derivatizing functional groups, making the method a time‐saving and efficient tool for metabolite identification if used in addition or in some cases as an alternative to common methods. Copyright © 2015 John Wiley & Sons, Ltd.
Psychological ownership: A review and research agenda
Authors: Dawkins Sarah , Tian Amy Wei , Newman Alexander , Martin Angela 
Published: October 2015

SummaryThe concept of psychological ownership (PO) reflects a state in which individuals feel as though the target of ownership (e.g., job or organization) is theirs. In recent years, there has been an expansion of research linking PO with a range of desirable employee attitudes and behaviors. However, the theoretical foundations of the construct, its measurement, the factors that influence its development, and when and how it influences outcomes are areas of continued debate in the literature. In this article, we provide a narrative review of extant PO literature with the aim of developing a research agenda that encourages scholars to target opportunities for future research. In particular, we highlight the need for continued refinement of the conceptualization and measurement of PO, and development of its nomological network. In addition, we call for greater investigation of PO towards different objects or foci; examination of possible multilevel applications of PO research; identification of potential boundary conditions of PO; and exploration of the influence of culture and individual differences on the development and influence of PO. We also introduce alternative theoretical approaches for understanding and investigating PO. In doing so, we provide a roadmap for scholars to progress the development of the field. Copyright © 2015 John Wiley & Sons, Ltd.
Squamous/adenosquamous carcinoma of the gallbladder: Analysis of 34 cases and comparison of clinicopathologic features and surgical outcomes with adenocarcinoma
Authors: Song Hu‐Wei , Chen Chen , Shen Hao‐Xin , Ma Li , Zhao Ya‐Ling , Zhang Guan‐Jun , Geng Zhi‐Min , Wang Lin 
Published: October 2015

ObjectivesTo explore clinicopathological features and effects of surgical treatment of squamous/adenosquamous carcinoma of the gallbladder.MethodsWe enrolled 411 patients who were surgically treated for gallbladder cancer in our hospital, including 10 with squamous cell carcinoma (SCC), 24 with adenosquamous carcinoma (ASC), and 377 with adenocarcinoma (AC). The ASC–SCC group was compared with the AC group for clinicopathological features and surgical outcomes.ResultsThe patients' average age was 61.4 years. Abdominal pain was the most common presenting symptom, and 67.6% of patients had gallstones. All patients had advanced‐stage (T3/T4) carcinomas. The ASC–SCC group had significantly higher percentages of T4 disease (61.8%) and N1 nodal involvement (58.8%) than did the AC group (T4 disease: 34.0%, P = 0.001; N1 involvement: 39.0%, P = 0.02). Patients in the ASC–SCC group who underwent R0 resections had significantly better 1‐year survival (30%) than those who underwent R1 or R2 resections (0%; P = 0.025), but lower 1‐year survival rates than similar‐staged patients in the AC group (69.3%; P = 0.016).ConclusionsPatients with gallbladder ASC–SCC were similar to those with AC in clinical characteristics, but tended to have more infiltration of multiple adjacent organs and lymphatic metastasis. Curative resection could give these patients better outcomes. J. Surg. Oncol. 2015;112:677–680. © 2015 Wiley Periodicals, Inc.
Recultivation of Agricultural Land Impaired by Construction of a Hydropower Plant on the Sava River, Slovenia
Authors: Zupanc Vesna , Kammerer Gerhard , Grčman Helena , Šantavec Igor , Cvejić Rozalija , Pintar Marina 
Published: October 2015

AbstractHydropower plants on the lower river Sava, Slovenia, were developed without sealing the underground upstream. As a consequence, without the countermeasures of elevating and recultivating, the agricultural land on the river banks would be inundated because of the water‐table increase of the river. To remedy this, the fields were elevated and recultivated. The goal of this study was to assess soil quality and production potential after land raising and recultivation and to answer the question whether it is possible to recover soil quality and crop yield after large‐scale mass manipulation, such as land raising. After recultivation and after the second year of land reuse for the two cultures grass–clover mixture and corn on two sites, Middle Pijavsko and Lower Pijavsko, soil physical and chemical characteristics and crop yields were evaluated. Mixing of topsoil with the second horizon during removal and during backfill with filling material resulted in uneven soil fertility, plant growth and decreased yield. Driving on the refilled second layer with heavy machinery caused soil compaction in the Middle Pijavsko in spite of favourable soil texture (loam, 38·7% sand). On the areas with very high sand content (over 55%) and low clay content (10%), soil compaction was not as severe or persistent. Recultivation measures restored the agricultural land almost to the production potential prior to powerplant construction. Immediate intensive land use (corn) showed less favourable effect on soil characteristics. Copyright © 2015 John Wiley & Sons, Ltd.
Ternary mixes with high mineral additions contents and corrosion related properties
Authors: Alonso M. C. , García Calvo J. L. , Sánchez M. , Fernandez A. 
Published: October 2015

AbstractThe choice of blended cements and materials with cementitious properties in concrete is currently seen as a choice that increases the environmental sustainability of the construction industry. The developments with non‐traditional binders (such as the simultaneous incorporation of several types of supplementary cementitious materials) have highlighted new challenges to be researched. In the present paper ternary binders were prepared by mixing ordinary Portland cement (OPC) plus two blended components: low calcium fly ash, blast furnace slag, and/or limestone filler. Several physical and mechanical properties of ternary blend systems have been analyzed in mortar form at several curing ages: 2, 7, 28, and 90 days. Additionally preliminary tests of corrosion performance of reinforcement in these types of mixes have been considered. The results indicate that the use of appropriate content components in ternary blends will allow binders to fulfill the specified mechanical requirements. The best results are obtained when two additions with antagonist properties are mixed, as fly ashes and slags or slags and filler limestone. Besides, certain influence of the effect on durability performance is detected, in particular associated with the stability of the passive state and corrosion of reinforcements in presence of chlorides.
Non‐traditional assessment and maintenance methods for aging concrete structures – technical and non‐technical issues
Authors: Polder R. B. , Peelen W. H. A. , Courage W. M. G. 
Published: October 2015

AbstractBased on construction dates and observed time to corrosion induced damage, the future need for repair of reinforced concrete motorway bridges in The Netherlands is predicted. Due to the age distribution and in particular the relatively short life of conventional repairs, the need for maintenance will increase steeply over the next few decades. It appears that a back log of postponed maintenance exists, which aggravates the problem. This steep rise may be mitigated by the application of various modern techniques for assessment, prevention, monitoring, and protection, that each have a good track record but are not widely used. Various factors that oppose the application of such innovations in the area of concrete maintenance are discussed.
Novel processing in inert atmosphere and in air to manufacture high‐activity slurry aluminide coatings modified by Pt and Pt/Ir
Authors: Galetz M. C. , Montero X. , Murakami H. 
Published: October 2015

AbstractSlurry‐derived coatings are an interesting alternative method to pack aluminization of nickel‐base superalloys, which provide similar properties and protection at high temperatures. For highest performance, these aluminide coatings are modified by the addition of Pt or, as recent research suggests, with Pt/Ir. While the combination of Pt and Pt/Ir with an out‐of‐pack process is state of the art, slurry coatings are of special interest as a repair method for turbine blades. In this study, the microstructural evolution of slurry‐derived coatings manufactured on CM 247 in inert atmosphere as well as in air was investigated. Layers of Ni, Pt, and Pt/Ir mixtures were electrodeposited. After annealing, a diffusion heat‐treatment with a slurry containing aluminum or aluminum–silicon powder was applied on the samples. The addition of silicon is well known to be beneficial for hot corrosion environments. The reaction and interdiffusion behavior of aluminum/aluminum–silicon determines the microstructural evolution of the coatings. Depending on the initial electroplated layer on the surface, different microstructures can be obtained, such as the Pt/Ir‐modified beta phase (Ni,Pt)Al or two‐phase layers of PtAl2 and NiAl. Additionally, the reactivity between the elements at the surface and those from the slurry was shown to determine homogeneity and surface roughness of the diffusion coating, also depending on the atmosphere used during slurry aluminization. Finally, it was demonstrated that iridium has a high influence on the diffusion behavior and especially the distribution of platinum in the coatings. Such new coatings have the potential to overcome some disadvantages of conventionally manufactured high‐activity aluminide coatings, as the combination of Pt/Ir‐electroplating with the slurry process results in less detrimental substrate elements like molybdenum or tungsten close to the surface.
A novel mutation of PDE8B Gene in a Japanese family with autosomal‐dominant striatal degeneration
Authors: Azuma Reo , Ishikawa Kinya , Hirata Kosei , Hashimoto Yuji , Takahashi Makoto , Ishii Kenji , Inaba Akira , Yokota Takanori , Orimo Satoshi 
Published: October 2015

AbstractBackgroundAutosomal‐dominant striatal degeneration is a rare autosomal‐dominant neurodegenerative movement disorder characterized by slowly progressive parkinsonism. Recently, a mutation of the cyclic nucleotide phosphodiesterase 8B gene was reported to be a causal gene mutation of this disease.MethodsWe report on the clinical characteristics of 2 patients of a Japanese family with autosomal‐dominant striatal degeneration and the result of gene mutation analysis of this family.ResultsClinical features of the patients are slowly progressive parkinsonism and brain MRI showing high signal intensity in T2‐weighted images in the striatum. We found a heterozygous nonsense mutation in the first exon of cyclic nucleotide phosphodiesterase 8B gene, which is predicted to disrupt all important functional domains of the cyclic nucleotide phosphodiesterase 8B protein.ConclusionsThis family is the second family with autosomal‐dominant striatal degeneration after the first German family, confirming that cyclic nucleotide phosphodiesterase 8B gene is the causative gene for this disease. © 2015 International Parkinson and Movement Disorder Society
Dual‐band printed monopole slot antenna with combination of L‐slot and ARM‐slot for WLAN application
Authors: Rahim Sharul Abdul , Nor Zairil , Jizat Noorlindawaty Md. , Sabran Mursyidul , Jamlos Mohd Faizal 
Published: October 2015

AbstractAntenna communication technologies were developing fast in recent research area, and these technologies demand high performance antenna to coop with the development. Wireless local area network (WLAN) application is famous term in antenna field nowadays, where this application allowed the users to communicate in long range without wired connection. WLAN demands an antenna with small size and volume, low in cost and weight, easy to design, and can perform efficiently at two distinct frequencies. In this article, the dual‐band antenna working at 2.45 and 5.8 GHz was proposed. The proposed antenna consists of L‐slots and arm's slot, where these slots greatly influenced the dual‐band ability. The combination of 45° of bending angle at all antenna edges and slots can enable the proposed antenna to have good performances in term of return losses, bandwidth percentages, and larger half‐power bandwidth (HPBW) values at both frequencies. The proposed antenna works efficiently at 2.45‐ and 5.8‐GHz frequency bands when this antenna gives return loss values of −25.1718 and −28.6754 dB, correspondingly. This device can generate a broad forward beam that covered −62.1 to 62.1° HPBW with 36% bandwidth at 2.45 GHz, whereas at 5.8‐GHz band, the HPBW for this antenna covered from −77.4 to 52.2° with 7.04% bandwidth. The proposed antenna suits to be used in WLAN's applications such as in Wi‐Fi, Bluetooth, and access point application. The proposed antenna measurement values meet the IEEE 802.11 standard to make this antenna reliable. © 2011 Wiley Periodicals, Inc. Microwave Opt Technol Lett 53:2668‐2673, 2011; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.26305