bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad metabolic sensitivity profiling of a prototrophic yeast deletion collection
Authors: VanderSluis Benjamin , Hess David C , Pesyna Colin , Krumholz Elias W , Syed Tahin , Szappanos Balázs , Nislow Corey , Papp Balázs , Troyanskaya Olga G , Myers Chad L , Caudy Amy A 
Published: April 2014

Abstract
Background
Genome-wide sensitivity screens in yeast have been immensely popular following the construction of a collection of deletion mutants of non-essential genes. However, the auxotrophic markers in this collection preclude experiments on minimal growth medium, one of the most informative metabolic environments. Here we present quantitative growth analysis for mutants in all 4,772 non-essential genes from our prototrophic deletion collection across a large set of metabolic conditions.

Results
The complete collection was grown in environments consisting of one of four possible carbon sources paired with one of seven nitrogen sources, for a total of 28 different well-defined metabolic environments. The relative contributions to mutants' fitness of each carbon and nitrogen source were determined using multivariate statistical methods. The mutant profiling recovered known and novel genes specific to the processing of nutrients and accurately predicted functional relationships, especially for metabolic functions. A benchmark of genome-scale metabolic network modeling is also given to demonstrate the level of agreement between current in silico predictions and hitherto unavailable experimental data.

Conclusions
These data address a fundamental deficiency in our understanding of the model eukaryote Saccharomyces cerevisiae and its response to the most basic of environments. While choice of carbon source has the greatest impact on cell growth, specific effects due to nitrogen source and interactions between the nutrients are frequent. We demonstrate utility in characterizing genes of unknown function and illustrate how these data can be integrated with other whole-genome screens to interpret similarities between seemingly diverse perturbation types.
Optimization and stabilization of gold nanoparticles by using herbal plant extract with microwave heating
Authors: Yasmin Akbar , Ramesh Kumaraswamy , Rajeshkumar Shanmugam 
Published: April 2014

Abstract
In this study, we have synthesized the gold nanoparticles by using Hibiscus rosa-sinensis, a medicinal plant. The gold nanoparticles were synthesized rapidly by the involvement of microwave heating. By changing of plant extract concentration, gold solution concentration, microwave heating time and power of microwave heating the optimized condition was identified. The surface Plasmon resonance found at 520 nm confirmed the gold nanoparticles synthesis. The spherical sized nanoparticles in the size range of 16–30 nm were confirmed by Transmission Electron Microscope (TEM). The stability of the nanoparticles is very well proved in the invitro stability tests. The biochemical like alkaloids and flavonoids play a vital role in the nanoparticles synthesis was identified using the Fourier Transform Infrared Spectroscopy (FTIR). Combining the phytochemical and microwave heating, the rapid synthesis of gold nanoparticles is the novel process for the medically applicable gold nanoparticles production.
Medicaid Medical Directors Quality Improvement Studies: A Case Study of Evolving
Methods for a Research Network
Authors: Fairbrother Gerry , Trudnak Tara , Katherine Griffith 
Published: April 2014

Objective: To describe the evolution of methods and share lessons learned from
conducting multi-state studies with Medicaid Medical Directors (MMD) using state
administrative data. There was a great need for these studies, but also much to be
learned about conducting network-based research and ensuring comparability of
results.Methods: This was a network-level case study. The findings were drawn from the
experience developing and executing network analyses with the MMDs, as well as from
participant feedback on lessons learned. For the latter, nine interviews with MMD
project leads, state data analysts, and outside researchers involved with the projects
were conducted. Interviews were transcribed, coded and analyzed using NVivo 10.0
analytic software.Findings: MMD study methodology involved many steps: developing
research questions, defining data specifications, organizing an aggregated data
collection spreadsheet form, assuring quality through review, and analyzing and
reporting state data at the national level. State analysts extracted the data from their
state Medicaid administrative (claims) databases (and sometimes other datasets).
Analysis at the national level aggregated state data overall, by demographics and other
sub groups, and displayed descriptive statistics and cross-tabs.Conclusions: Projects in
the MMD multi-state network address high-priority clinical issues in Medicaid and impact
quality of care through sharing of data and policies among states. Further, these
studies contribute not only to high-quality, cost-effective health care for Medicaid
beneficiaries, but also add to our knowledge of network-based research. Continuation of
these studies requires funding for a permanent research infrastructure nationally, as
well as at the state-level to strengthen capacity.
On the limit of spectral measures associated to a test configuration of a polarized Kähler manifold
Authors: Hisamoto Tomoyuki 
Published: April 2014

Abstract

We apply our integral formula of volumes to the family of graded linear series constructed from any test configuration. This solves the conjecture raised by Witt Nyström to the effect that the sequence of spectral measures for the induced ℂ*-action on the central fiber converges to the canonical measure defined by the associated weak geodesic ray in the space of Kähler metrics. This limit measure coincides with the classical Duistermaat–Heckmann measure if the test configuration is product. As a consequence, we show that the algebraic p-norm of the test configuration is equal to the Lp
-norm of tangent vectors on the geodesic ray. Using this result, we give a natural energy theoretic explanation for the lower bound estimate on the Calabi functional by Donaldson, extending the statement to any p-norm (p ≥ 1), and prove an analogous result for Kähler–Einstein metrics.
Emergency Messenger als Kommunikationskonzept für Notfallarbeit/ EmergencyMessenger as a Communication Concept for Emergency Response Work
Authors: Betz Matthias , Dyrks Tobias , Wulf Volker 
Published: April 2014

Zusammenfassung
Das Auffinden und Retten von vermissten oder verletzten Personen und die Brandbekämpfung im Innenangriff stellt eine zentrale Herausforderung für Feuerwehreinsatzkräfte dar. Um die Sicherheit der Trupps im Innenangriff zu gewährleisten, ist das Beobachten und Nachhalten der Aktivitäten solcher Trupps durch die übergeordnete Führungsebene von zentraler Bedeutung. Feuerwehrleute in Deutschland nutzen Sprechfunkgeräte, um einen verbalen Kommunikationskanal zu den übergeordneten und verantwortlichen Führungskräften zu etablieren. Basierend auf den Ergebnissen ethnografischer Studien in Kooperation mit verschiedenen deutschen Feuerwehren über einen Zeitraum von fünf Jahren wurden die Vor- und Nachteile der etablierten Kommunikationstaktiken und -techniken eingehend analysiert. Im Zuge der Forschungs- und Entwicklungsarbeiten im Forschungsprojekt „Koordinator“ wurde ein komplementäres textbasiertes Meldesystem konzeptioniert, gestaltet und evaluiert, um die anstrengende, gefährliche und zeitkritische Arbeit von Atemschutztrupps im Innenangriff zu unterstützen. Dazu wurden gemeinsam mit einer Arbeitsgruppe von Feuerwehrleuten in insgesamt 13 Einsatzübungen durchgeführt. Dies umfasst die Vorbereitung, Durchführung und Evaluation der Einsatzerfahrungen in Form gemeinsamer Gruppenarbeit.
#Hochwasser – Visuelle Analyse von Social Media im Bevölkerungsschutz / #Hochwasser – Using Visual Analytics of social media in civil protection
Authors: Zisgen Julia , Kern Julia , Thom Dennis , Ertl Thomas 
Published: April 2014

Zusammenfassung
Anhand des Hochwassers 2013 in Deutschland soll in diesem Artikel untersucht werden, ob sich die Lageeinschätzung zur Krisenreaktion durch die Auswertung von Social Media-Daten verbessern lässt. Dabei soll insbesondere gezeigt werden, dass Techniken zur computergestützten explorativen Datenanalyse geeignet sind, um trotz der noch recht dünnen Datenlage relevante Erkenntnisse zu gewinnen. Neben einer allgemeinen Erörterung zu Nutzen und Möglichkeiten von Social Media-Daten im Bevölkerungsschutz wird dabei Scatterblogs, ein bestehendes interaktives Social Media- Analysewerkzeug, kurz vorgestellt und evaluiert. Dabei werden Daten verwendet, die während des Hochwassers aufgezeichnet wurden.
Berichte aus der Usability/UX Branche: Ausbildungswege, Arbeitsfeld und aktuelle Diskussionen
Authors: Kolb Nina , Diefenbach Sarah , Ullrich Daniel 
Published: April 2014

Zusammenfassung
Gute Usability und User Experience sind mittlerweile allgemein anerkannte Qualitätskriterien, werden vom Nutzer aber auch eingefordert und erwartet. Hier beginnt der Job der Usability und User Experience (UX) Professionals. Mit dem jährlich erscheinenden Branchenreport Usability gibt die German UPA (Berufsverband der deutschen Usability und User Experience Professionals, www.germanupa.de) einen Eindruck in das Berufsbild von Usability und User Experience Professionals und berichtet über Entwicklungen, aktuelle Themen sowie die bekanntesten Unternehmen der Branche. Auf Basis des Branchenreports 2013 und der Angaben von 356 Teilnehmern berichtet der vorliegende Beitrag zentrale Kennzahlen und Entwicklungen der Branche. Neben Informationen zu Ausbildungswegen, dem Arbeitsfeld Usability/UX sowie aktuellen Diskussionen der Branche greift der Beitrag einige Schwerpunktthemen auf wie beispielsweise eine genauere Betrachtung der Arbeitssituationen hinter einzelnen Jobbezeichnungen (z. B. Usability Engineer, UX Consultant), eine Beleuchtung der speziellen Arbeitssituation und typischen Werdegängen der Freiberufler sowie die Abgrenzung der Begriffe User Experience und Usability.
Morphology and ferroelectric properties of Ce-substituted Bi4 Ti3 O12 thin films prepared by sol-gel method
Authors: Li Sanxi , Wei Nan , Zhang Wenzheng 
Published: April 2014

Abstract
The Ce-substituted bismuth titanate (Bi4 Ti3 O12) ferroelectric thin films were prepared on Pt/Ti/SiO2/Si substrates by sol-gel method and annealed at 700°C. The Bi-layered perovskite (with Ce substitution for Bi) single phase films were obtained and the thickness was 500 nm. At 12 V amplitude and 1000 Hz frequency, ferroelectric tests results showed a hysteresis loop with remnant polarization (2Pr) and coercive field values (2Ec) of 9.86 μC/cm2 and 208 kV/cm, respectively. The structure and lattice parameters were analyzed by X-ray diffraction (XRD). The results showed that by increasing Ce substitution the ratio of a/c, the ferroelectric properties, increased when the Ce-substitution of 0.6, a and c values were 5.40734 Å and 5.3559 Å, respectively. The a-axis highly oriented structure may have influenced the remnant polarization and coercive field values of the films obtained.
Mechanical behavior of walnut (Juglans L.) shell particles reinforced bio-composite
Authors: Singh Vinay K. 
Published: April 2014

AbstractIn the present work walnut particle reinforced composite material was developed. Ten wt%, 15 wt%, 20 wt% and 25 wt% (weight percentage) of walnut particles were mixed with epoxy resin (CY-230). Scanning electron microscopy (SEM) shows that the walnut particles were well dispersed in the epoxy resin matrix. Addition of walnut particles increased the modulus of elasticity of the bio composite. Addition of walnut particles in bio composite decreased the ultimate strength both in compression and tension. However, addition of walnut particles in bio composite increased the hardness. Flexural modulus of elasticity also increased with increasing walnut particles weight percentage, whereas flexural strength and strain decreased with increased weight percentage of walnut particles.
Factor instrumental variable quantile regression
Authors: Chen Jau-er 
Published: April 2014

AbstractThis paper proposes a factor instrumental variable quantile regression (FIVQR) estimator and studies its asymptotic properties. The proposed estimators share with quantile regression the advantage of exploring the shape of the conditional distribution of the dependent variable. When there are a factor structure and co-movement for economic variables, the underlying unobservable factors (or common components) are more efficient instruments. The proposed estimators achieve the optimality in the following sense: The method of principal component consistently estimates the space spanned by the ideal instruments which are utilized to control the endogeneity in the quantile regression analysis. Analyzing the asymptotic properties of the estimator, we assume that a panel of observable instruments follows a factor structure and the endogenous variables also share the same unobservable factors. Using the estimated factors as instruments, we show that the FIVQR estimator is consistent and asymptotically normal. Furthermore, when compared in the GMM framework, the proposed estimator is more efficient than the GMM estimator using many observable instruments directly. Monte Carlo studies demonstrate that the proposed estimators perform well. For an empirical application, we use a firm-level panel data set consisting of trading volumes and returns on DJIA to explore the asymmetric return–volume relation, controlling the endogeneity problem with the estimated factor instruments.
Qualification and comparison in Berber. The verb-noun distinction and its Fluctuations
Authors: Taine-Cheikh Catherine 
Published: April 2014

Abstract
The world's languages generally distinguish between nouns and verbs. However, many do not have a specific class of adjectives with its own significantly different grammatical properties to set it apart from nouns and verbs. This is true of Berber which, in this respect, differs from Arabic. That being said, if one looks at the details, there is wide variety across Berber languages. Most have both ``verbal'' adjectives and ``nominal'' adjectives, with more or less marked secondary properties. Some have a small adjective class for describing certain core properties. Historically, these could reflect an earlier phase of Berber.
Postchemotherapy Surgery for Germ Cell Tumors—What Have We Learned in 35 Years?
Authors: Riggs Stephen B. , Burgess Earl F. , Gaston Kris E. , Merwarth Caroline A. , Raghavan Derek 
Published: April 2014

Abstract
Postchemotherapy surgery for advanced testicular cancer has evolved over the last couple of decades. Patients with nonseminomatous germ cell tumors and residual retroperitoneal mass ≥1 cm should undergo postchemotherapy retroperitoneal lymph node dissection (RPLND). For seminoma, RPLND is considered in those patients with masses ≥3 cm that are also positron emission tomography positive. Masses that occur outside of the retroperitoneum should be completely resected with the possible exception of bilateral lung masses when resection of the first mass shows necrosis. The role of surgery in patients with extragonadal germ cell tumors is most vital in those with primary mediastinal nonseminomatous germ cell tumors. Importantly, patient selection, surgical planning, and consideration of referral to centers with this expertise are important to optimize success.
Influence of Cavity Preparation, Light-curing Units, and Composite Filling on Intrapulpal Temperature Increase in an In Vitro Tooth Model
Authors: Choi SH , Roulet JF , Heintze SD , Park SH 
Published: April 2014

SUMMARY
This study examined the effect of both the tooth substance and restorative filling materials on the increase in pulp chamber temperature when using light-curing units with different power densities.
The tip of a temperature sensor was positioned on the pulpal dentinal wall of the buccal side of a maxillary premolar. Metal tubes were inserted in the palatal and buccal root of the tooth, one for water inflow and the other for water outflow. Polyethylene tubes were connected from the metal tubes to a pump to control the flow rate. For the unprepared tooth group (group 1), the tooth was light-cured from the buccal side using two light-curing units (three curing modes): the VIP Junior (QTH, BISCO, Schaumburg, IL, USA) and the Bluephase LED light-curing units (two modes: LEDlow and LEDhigh; Ivoclar Vivadent, Schaan, Liechtenstein). The power densities of each light-curing unit for the LEDlow, QTH, and LEDhigh modes were 785 mW/cm2, 891 mW/cm2, and 1447 mW/cm2, respectively. All light-curing units were activated for 60 seconds. For the prepared tooth group (group 2), a Class V cavity, 4.0 mm in width by 4.0 mm in height by 1.8 mm in depth in size, was prepared on the buccal surface of the same tooth for the temperature measurement. The light-curing and temperature measurements were performed using the same methods used in group 1.
The cavity prepared in group 2 was filled with a resin composite (Tetric N Ceram A3 shade, Ivoclar Vivadent) (group 3) or a flowable composite (Tetric N Flow with A3 shade, Ivoclar Vivadent) (group 4). The light-curing and temperature measurements were performed for these groups using the same methods used for the other groups.
The highest intrapulpal temperature (TMAX) was measured, and a comparison was conducted between the groups using two-way analysis of variance with a post hoc Tukey test at the 95% confidence level.
The TMAX values were as follows: 38.4°C (group 1), 39.0°C (group 2), 39.8°C (group 3), and 40.3°C (group 4) for the LEDlow mode. For the QTH mode, the TMAX values were 40.1°C (group 1), 40.4°C (group 2), 40.9°C (group 3), and 41.4°C (group 4). For the LEDhigh mode, the TMAX values were 43.3°C (group 1), 44.5°C (group 2), 44.7°C (group 3), and 45.3°C (group 4). The statistical analysis revealed the following: the TMAX values were arranged by mode in the following manner: LEDlow &lt; QTH &lt; LEDhigh (p&lt;0.05) and group 1 &lt; group 2 ≤ group 3 ≤ group 4 (p&lt;0.05).
A Comprehensive Laboratory Screening of Three-Step Etch-and-Rinse Adhesives
Authors: Loguercio AD , Luque-Martinez I , Muñoz MA , Szesz AL , Cuadros-Sánchez J , Reis A 
Published: April 2014

SUMMARY

Objectives
This study evaluated several bonding (microtensile bond strengths [μTBS], nanoleakage [NL], and in situ degree of conversion [ISDC] on dentin) and mechanical properties (ultimate tensile strength [UTS], degree of conversion [DC], water sorption [WS], and solubility [SL] in water) of four three-step etch-and-rinse adhesives in the short term.

Methods
A total of 28 molars were used in this study. The dentin surfaces were bonded with the following adhesives: All-Bond 3 (ALB3); Fusion Duralink (FSDL); Optibond FL (OBFL), and Scotchbond Multi-Purpose (SBMP). After each adhesive-system application, composite resin build-ups were added. For bonding tests, specimens were sectioned in order to obtain bonded sticks. The sticks were divided to be tested for μTBS (0.5 mm/min), for NL (n=2), and ISDC (n=2). For NL, they were immersed in 50% silver nitrate and analyzed by scanning election microscopy. For ISDC, the hybrid layer was evaluated by micro-Raman spectroscopy. An hourglass-shaped matrix (UTS) or disk-shaped matrix (WS and SL) was filled with primer and adhesive (1:1 ratio) and light-polymerized. For UTS evaluation, the specimens were tested under tension. For WS and SL, specimens were desiccated and stored in distilled water to evaluate water diffusion kinetics over a 28-day period. The DC of the adhesives was evaluated by Fourier transformed infrared spectroscopy. The data from each test were analyzed by appropriate statistical methods.

Results
OBFL resulted in the highest μTBS, lower NL, higher ISDC and DC, and higher UTS than other adhesives (p&lt;0.05), as well as lower WS (similar to ALB3 and FSDL) and SL (similar to ALB3 and SBMP) (p&gt;0.05). ALB3 showed a higher NL and the lowest DC value. FSDL showed the highest NL and SL and the lowest ISDC. SBMP showed the lowest pattern of WS (p&lt;0.05).

Conclusion
OBFL showed the best results in all the properties evaluated, and it can be considered the gold standard of the three-step etch-and-rinse adhesive systems.
“Well, Melody, what is your skirt gonna turn into now?”: An Interview with Melody Mangler
Authors: Ortner Ines 
Published: April 2014

Abstract: Melody Mangler is a highly acclaimed burlesque performer, teacher, costumer, and writer from Vancouver. In 2009, the Burlesque Hall of Fame recognized her talents with the “Best Debut” Award for her outstanding performance piece Venus in Spring. As a founding member of the Screaming Chicken Theatrical Society and their current artistic director, she contributes significantly to the Vancouver burlesque scene. This interview centres on the role costumes play in Melody Mangler’s performance process from their inspiration to their construction, and as a stage partner. The conversation covers various aspects of costume design: the historical burlesque, the connotation of fashion-before-function, the ingenuity required during the building process, and the technical complexity in the creation and play all burlesque costumes involve. Mangler also speaks to the creative adjustments of conventions, the inherited satirical characteristic of the neo-burlesque as well as the significance of sex-positivity and body-positivity.
Backwoods Burlesque: Off-the-Grid Tsk Tsk
Authors: Preece Bronwyn 
Published: April 2014

Abstract: The Tsk Tsk Revue has become an annual one-night event—perhaps now more accurately described as a phenomenon—in the 350-peopled, entirely off-the-grid island of Lasqueti, BC, developing into a Gulf islands’ touring show. Teeming with brazen backwoods humour and localized, alternatively-powered erotics, the Tsk Tsk Revue has rightfully earned a unique place on the national burlesque scene. The show spins both the term sexy and the status quo on their heads, highlighting the often-absurd moments of choosing to live off-the-grid and translating the many challenges that face the islanders into comedic fodder. Staging innovative low-tech stage tropes, costumes, and black light burlesque through a series of vignettes strung together by the colourful commentary of the show’s creator and hostess, Jenny Vester, the Tsk Tsk Revue continually pushes the limits and tests one remote little island’s limits.
Neo-Burlesque and the Resurgence of Roller Derby: Empowerment, Play, and Community
Authors: Owen David 
Published: April 2014

Abstract: In both neo-burlesque and roller derby, there is a two-way communication between the audience (both male and female) and the performers/athletes that celebrates what the women (and sometimes men) on stage and on the track are doing. Using interviews with several burlesque performers and derby players, I demonstrate that there is a sense of community at both events between performers and audience, and that the art form of burlesque is not about monetary gain or exclusively for the pleasure of men. The burlesque performer is continually in communication with the audience through eye contact, performer-initiated physical contact, and invited audible response. I draw a parallel to roller derby as another outlet for women to express themselves outside of a traditional patriarchal frame for an audience of both women and men, paying particular attention to the acceptance of a wide range of body types, the creation of community, and a celebration of strength and skill not usually associated with women.