bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progression of brain atrophy in the early stages of Parkinson's disease: A longitudinal tensor‐based morphometry study in de novo patients without cognitive impairment
Authors: Tessa Carlo , Lucetti Claudio , Giannelli Marco , Diciotti Stefano , Poletti Michele , Danti Sabrina , Baldacci Filippo , Vignali Claudio , Bonuccelli Ubaldo , Mascalchi Mario , Toschi Nicola 
Published: January 2014

AbstractThe presence of brain atrophy and its progression in early Parkinson's disease (PD) are still a matter of debate, particularly in patients without cognitive impairment. The aim of this longitudinal study was to assess whether PD patients who remain cognitively intact develop progressive atrophic changes in the early stages of the disease. For this purpose, we employed high‐resolution T1‐weighted MR imaging to compare 22 drug‐naïve de novo PD patients without cognitive impairment to 17 age‐matched control subjects, both at baseline and at three‐year follow‐up. We used tensor‐based morphometry to explore the presence of atrophic changes at baseline and to compute yearly atrophy rates, after which we performed voxel‐wise group comparisons using threshold‐free cluster enhancement. At baseline, we did not observe significant differences in regional atrophy in PD patients with respect to control subjects. In contrast, PD patients showed significantly higher yearly atrophy rates in the prefrontal cortex, anterior cingulum, caudate nucleus, and thalamus when compared to control subjects. Our results indicate that even cognitively preserved PD patients show progressive cortical and subcortical atrophic changes in regions related to cognitive functions and that these changes are already detectable in the early stages of the disease.Hum Brain Mapp 35:3932–3944, 2014. ©2014 Wiley Periodicals, Inc.
Aging effects on the resting state motor network and interlimb coordination
Authors: Solesio‐Jofre Elena , Serbruyns Leen , Woolley Daniel G. , Mantini Dante , Beets Iseult A. M. , Swinnen Stephan P. 
Published: January 2014

AbstractBoth increases and decreases in resting state functional connectivity have been previously observed within the motor network during aging. Moreover, the relationship between altered functional connectivity and age‐related declines in bimanual coordination remains unclear. Here, we explored the developmental dynamics of the resting brain within a task‐specific motor network in a sample of 128 healthy participants, aged 18–80 years. We found that age‐related increases in functional connectivity between interhemispheric dorsal and ventral premotor areas were associated with poorer performance on a novel bimanual visuomotor task. Additionally, a control analysis performed on the default mode network confirmed that our age‐related increases in functional connectivity were specific to the motor system. Our findings suggest that increases in functional connectivity within the resting state motor network with aging reflect a loss of functional specialization that may not only occur in the active brain but also in the resting brain. Hum Brain Mapp 35:3945–3961, 2014. © 2014 Wiley Periodicals, Inc.
Impact of methodological variables on functional connectivity findings in autism spectrum disorders
Authors: Nair Aarti , Keown Christopher L. , Datko Michael , Shih Patricia , Keehn Brandon , Müller Ralph‐Axel 
Published: January 2014

AbstractGrowing evidence suggests that Autism Spectrum Disorder (ASD) involves abnormalities of multiple functional networks. Neuroimaging studies of ASD have therefore increasingly focused on connectivity. Many functional connectivity (fcMRI) studies have reported network underconnectivity in children and adults with ASD. However, there are notable inconsistencies, with some studies reporting overconnectivity. A previous literature survey suggested that a few methodological factors play a crucial role in differential fcMRI outcomes. Using three ASD data sets (two task‐related, one resting state) from 54 ASD and 51 typically developing (TD) participants (ages 9–18 years), we examined the impact of four methodological factors: type of pipeline (co‐activation vs. intrinsic analysis, related to temporal filtering and removal of task‐related effects), seed selection, field of view (whole brain vs. limited ROIs), and dataset. Significant effects were found for type of pipeline, field of view, and dataset. Notably, for each dataset results ranging from robust underconnectivity to robust overconnectivity were detected, depending on the type of pipeline, with intrinsic fcMRI analyses (low bandpass filter and task regressor) predominantly yielding overconnectivity in ASD, but co‐activation analyses (no low bandpass filter or task removal) mostly generating underconnectivity findings. These results suggest that methodological variables have dramatic impact on group differences reported in fcMRI studies. Improved awareness of their implications appears indispensible in fcMRI studies when inferences about “underconnectivity” or “overconnectivity” in ASD are made. In the absence of a gold standard for functional connectivity, the combination of different methodological approaches promises a more comprehensive understanding of connectivity in ASD. Hum Brain Mapp 35:4035–4048, 2014. © 2014 Wiley Periodicals,Inc.
Learning from parents' stories about what works in early intervention
Authors: Pighini Maria J. , Goelman Hillel , Buchanan Marla , Schonert‐Reichl Kimberly , Brynelsen Dana 
Published: January 2014

AbstractUsing a multiple case study approach, this ethnography examined the experiences of parents of children deemed at risk for developmental delays or disabilities who had received early intervention (EI) services (birth to age 3 years) in a large urban location in Western Canada. Participants (11 adult parents and 7 children) were drawn from six families. Methods of data collection included focus groups (FG), face‐to‐face interviews and file reviews. Member check and expert reviews were conducted throughout data collection and data analyses as part of the validation process in this ethnography. Qualitative content analyses followed by thematic analyses highlighted the implementation of family‐centred practices (FCP) as a main theme. Parents identified how EI professionals using FCP embraced collaborative practices. FCP resulted in parents leading the EI process for their children. More specifically, EI professionals shared strategies and information to support parents in gaining a deeper understanding of their children's individual developmental characteristics. Parents expressed how empowering this level of understanding was for them as they learned to articulate what were their children's needs for developmental, health and educational services. Recommendations for future research include inquiring about parents' experiences for families of diverse constellations and/or residing in smaller urban or rural communities.
Ambivalent sexism, attitudes towards menstruation and menstrual cycle‐related symptoms
Authors: Marván Ma. Luisa , Vázquez‐Toboada Rocío , Chrisler Joan C. 
Published: January 2014

AbstractThe objective of the present study was to investigate the relationship between ambivalent sexism and beliefs and attitudes towards menstruation, and, in turn, to study the influence of these variables on menstrual cycle‐related symptoms. One hundred and six Mexican women completed the Ambivalent Sexism Inventory, the Beliefs about and Attitudes toward Menstruation Questionnaire and the Menstrual Distress Questionnaire. The higher scores on benevolent sexism were associated with the most positive attitudes towards menstruation and also with the belief that a menstruating woman should or should not do some activities and that menstruation keeps women from their daily activities. The higher scores on hostile sexism were associated with rejection of menstruation as well as with feelings of embarrassment about it. Beliefs about and attitudes towards menstruation predicted menstrual cycle‐related symptoms related to negative affect, impaired concentration and behavioural changes, but did not predict somatic symptoms. These results will be useful to health professionals and advocates who want to change the negative expectations and stereotypes of premenstrual and menstrual women and reduce the sexism and negative attitudes towards women that are evident in Mexican culture.
Highly effective antibiofilm coating of silver–polymer nanocomposite on polymeric medical devices deposited by one step plasma process
Authors: Agarwala Munin , Barman Tapan , Gogoi Dolly , Choudhury Bula , Pal Arup R. , Yadav R. N. S. 
Published: January 2014

AbstractFoley's catheters were coated with Silver (Ag), plasma polymerized aniline (PPAni) and Ag−PPAni composite by plasma based deposition processes which were characterized by XRD, EDX, SEM, and FT‐IR spectroscopy and bioassays were performed to validate their efficacies to kill planktonic cells as well as to remove biofilm. The analyses confirmed the formation of Ag nanoparticles (AgNPs), PPAni and Ag−PPAni composite and also corroborated their successful deposition over the catheters. Antibacterial assays showed that coated catheters were capable of killing planktonic cells of most commonly encountered uropathogens and equally capable of eradicating biofilm formation by the uropathogens as evident from the reduced cfu/ml. UV–vis spectroscopy results showed that the nanoparticle coated catheters were capable of gradual release of AgNPs, killing all planktonic cells in solution over the time. Foley's catheters coated with AgNPs and their composites by one step plasma process were non‐toxic devices capable of killing planktonic cells and proficient in eradicating biofilm formation which could be used to cutback the likelihood of the catheter related complications. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1223–1235, 2014.
An atmospheric‐pressure plasma‐treated titanium surface potentially supports initial cell adhesion, growth, and differentiation of cultured human prenatal‐derived osteoblastic cells
Authors: Kawase Tomoyuki , Tanaka Takaaki , Minbu Hiromi , Kamiya Mana , Oda Masafumi , Hara Toshiaki 
Published: January 2014

AbstractAn atmospheric‐pressure plasma (APP) treatment was recently reported to render titanium (Ti) surfaces more suitable for osteoblastic cell proliferation and osteogenesis. However, the mechanism of action remains to be clearly demonstrated. In this study, we focused on cell adhesion and examined the effects of the APP treatment on the initial responses of human prenatal‐derived osteoblastic cells incubated on chemically polished commercially pure Ti (CP‐cpTi) plates. In the medium containing 1% fetal bovine serum, the initial cell adhesion and the actin polymerization were evaluated by scanning electron microscopy and fluorescence microscopy. The expression of cell adhesion‐related molecules and osteoblast markers at the messenger RNA level was assessed by real‐time quantitative polymerase chain reaction. Although the cells on the APP‐treated CP‐cpTi surface developed fewer cytoskeletal actin fibers, they attached with higher affinity and consequently proliferated more actively (1.46‐fold over control at 72 h). However, most of the cell adhesion molecule genes were significantly downregulated (from 40 to 85% of control) in the cells incubated on the APP‐treated CP‐cpTi surface at 24 h. Similarly, the osteoblast marker genes were significantly downregulated (from 49 to 63% of control) at 72 h. However, the osteoblast marker genes were drastically upregulated (from 197 to 296% of control) in these cells by dexamethasone and β‐glycerophosphate treatment. These findings suggest that the APP treatment improves the ability of the CP‐cpTi surface to support osteoblastic proliferation by enhancing the initial cell adhesion and supports osteoblastic differentiation when immature osteoblasts begin the differentiation process. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1289–1296, 2014.
Evolution of fetal ventricular dilatation in relation to severity at first presentation
Authors: Lam Sarah‐Jane , Kumar Sailesh 
Published: January 2014

ABSTRACTBackgroundTo assess the outcome of 360 cases of fetal ventriculomegaly in a tertiary referral center.MethodsCases of fetal ventriculomegaly between June 1993 and December 2011 were identified from the departmental fetal database. The fetal medicine reports and obstetric notes were reviewed to ascertain the antenatal progression of the ventriculomegaly as well as the outcome of the pregnancy. Ventriculomegaly was defined by a lateral ventricular wall atrial measurement of greater than 10 mm. Cases were subdivided into mild (>10 to <12 mm), moderate (≥12 to <15 mm), and severe (≥15 mm). Termination of pregnancy was offered in cases where there were associated anomalies, aneuploidy, or the ventriculomegaly progressed.ResultsOf the 360 cases, 189 were mild, 79 were moderate, and 92 were severe. Sixty‐four percent of cases had associated anomalies. Forty‐six percent of cases in the mild group and 26% in the moderate group resolved. Only one case in the severe group improved. The mean rate of progression in the mild group was 1.07 (SD 1.03) mm/week, whereas in the moderate group progression was at a mean rate of 1.41 (SD 0.77) mm/week. Progression of severe ventriculomegaly was significantly higher at a mean rate of 3.26 (SD 2.92) mm/week (p = 0.007).ConclusionsThe majority of fetuses with mild ventriculomegaly normalized, whereas the majority of moderate cases remained stable. The rate of progression of ventriculomegaly increased with severity. Fetuses with ventriculomegaly should be offered serial scans to allow the progression of ventriculomegaly to be ascertained with the option of late termination of pregnancy. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 42:193–198, 2014
Extrinsic pulmonary stenosis in primary mediastinal B‐cellular lymphoma
Authors: Pugliatti Pietro , Donato Rocco , Grimaldi Patrizia , Nunnari Flavia , de Gregorio Cesare , Zito Concetta , Carerj Scipione 
Published: January 2014

ABSTRACTWe describe the case of a 34‐year‐old man with a history of asthenia and excessive fatigability. Transthoracic echocardiography showed a mass in the right ventricular outflow tract with a peak systolic gradient of 52 mmHg. Contrast‐enhanced CT confirmed the presence of a lobulated mass, which extensively filled the anterior mediastinum, infiltrating the pulmonary artery trunk up to occupying the right ventricular outflow tract. CT‐guided biopsy revealed primary mediastinal B‐cellular lymphoma. The patient underwent chemotherapy, achieving complete remission of the disease at the 12‐month follow‐up, while the gradient across the pulmonary artery dropped from 52 mmHg to 14 mmHg. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 43:68–70, 2015
Doppler assessment of splanchnic arterial flow in patients with liver cirrhosis: Correlation with ammonia plasma levels and MELD score
Authors: Glišić Tijana M. , Perišić Mirjana D. , Dimitrijevic Sladjana , Jurišić Vladimir 
Published: January 2014

ABSTRACTPurposeTo assess the clinical significance of blood flow velocity and resistance index (RI) in the visceral arteries of patients with liver cirrhosis with respect to plasma ammonia (NH3) level and liver function.MethodsWe included 80 patients with liver cirrhosis (58 men) and 20 healthy controls (11 men). Duplex Doppler ultrasonography was used to assess flow velocity and RI in the hepatic (HA), right (RRA), and left renal (LRA), and splenic (SA) (LA) artery. Plasma NH3 was measured by biochemistry. Liver function was assessed by MELD score (model of end‐stage liver disease).ResultsHA, LRA, and SA systolic flow velocities were greater, whereas RRA diastolic velocity was lower in patients with liver cirrhosis than in controls RI was higher in LRA, RRA, SA, and HA in patients with liver cirrhosis than in controls. NH3 levels were significantly elevated in all patients with liver cirrhosis (p < 0.05) and significantly correlated with RI of RRA, LRA, and SA.ConclusionWe found greater renal, hepatic, and LA RI in patients with liver cirrhosis than in healthy controls. The correlation we found between elevated renal artery RI (≥0.70) and MELD score emphasizes the risk of renal dysfunction during progression of liver cirrhosis. © 2014 Wiley Periodicals, Inc. J Clin Ultrasound 42:264–269, 2014
Arc‐Disjoint In‐ and Out‐Branchings With the Same Root in Locally Semicomplete Digraphs
Authors: Bang‐Jensen Jørgen , Huang Jing 
Published: January 2014

AbstractDeciding whether a digraph contains a pair of arc‐disjoint in‐ and out‐branchings rooted at a specified vertex is a well‐known NP‐complete problem (as proved by Thomassen, see ). This problem has been shown to be polynomial time solvable for semicomplete digraphs and for quasi‐transitive digraphs . In this article, we study the problem for locally semicomplete digraphs. We characterize locally semicomplete digraphs that contain a pair of arc‐disjoint in‐ and out‐branchings rooted at a specified vertex. Our proofs are constructive and imply the existence of a polynomial time algorithm for finding the desired branchings when they exist. Our results generalizes those from for semicomplete digraphs and solves an open problem from .
Determination of volatile compounds in turbot (Psetta maxima) during refrigerated storage by headspace solid‐phase microextraction and gas chromatography–mass spectrometry
Authors: Xu Yongxia , Liu Ying , Jiang Chengcheng , Zhang Chaomin , Li Xuepeng , Zhu Danshi , Li Jianrong 
Published: January 2014

AbstractBACKGROUNDA procedure based on headspace solid phase microextraction (HS‐SPME) and gas chromatography–mass spectrometry (GC‐MS) was developed for the study of the volatile profile characteristics of turbot during refrigerated storage at 4°C for 20 days in order to find possible markers of freshness or spoilage.RESULTSA total of 61 volatile compounds including aldehydes, ketones, esters, alcohols, alkenes, alkanes, aromatics, amines and others were identified in turbot muscle extracted by the optimised HS‐SPME method. The volatile profile characteristics of turbot at different storage periods were specified by principal component analysis (PCA). The concentrations of hexanal, heptanal, (2E,4E)‐heptadienal, acetophenone, 2‐undecanone and 1‐octen‐3‐ol decreased during storage, whereas benzene acetaldehyde, 6‐methyl‐5‐hepten‐2‐one, 2‐nonanone, acetic acid butyl ester, 3‐methyl‐1‐butanol and trimethylamine increased.CONCLUSIONSPME‐GC‐MS combined with PCA may be a useful method for monitoring the volatile profile characteristics of turbot during storage, which could be potentially used for freshness evaluation. © 2014 Society of Chemical Industry
Wolfberries potentiate mitophagy and enhance mitochondrial biogenesis leading to prevention of hepatic steatosis in obese mice: The role of AMP‐activated protein kinase α2 subunit
Authors: Lin Dingbo , He Hui , Ji Hua , Willis Jordan , Willard Lloyd , Jiang Yu , Medeiros Denis M. , Wark Logan , Han Jing , Liu Yongzhang , Lu Bin 
Published: January 2014

ScopeThe aim of this study is to investigate whether AMP‐activated protein kinase α2 (AMPKα2) is essential for wolfberry's protective effects on mitochondrial dysfunction and subsequent hepatic steatosis in mice.Methods and resultsSix‐week‐old male AMPKα2 knockout mice and genetic background C57BL/6J (B6) mice were fed a control, high‐fat diet (HD, 45% (kilocalorie) fat), and/or HD with 5% (kilocalarie) wolfberry diets for 18 wk. At termination, blood and liver tissues were sampled for analysis by ELISA, HPLC, microscopy, real‐time PCR, and Western blot. HD lowered hepatic lutein and zeaxanthin contents, inhibited protein expression of β,β‐carotene 9′,10′‐oxygenase 2 (BCO2) and heat shock protein 60 in mitochondria, increased reactive oxygen species level, and suppressed mitophagy and mitochondrial biogenesis as determined by accumulation of p62, inhibited phosphorylation of Unc‐51‐like kinase 1 on Ser555, and declined expression of peroxisome proliferator‐activated receptor γ coactivator 1 α, resulting in hepatic steatosis in B6 and knockout mice. Dietary wolfberry elevated the xanthophyll concentrations and enhanced expression of BCO2 and heat shock protein 60, attenuated mitochondrial oxidative stress, activated AMPKα2, potentiated mitophagy and mitochondrial biogenesis, and enhanced lipid oxidation and secretion in the liver of B6 mice.ConclusionDietary wolfberry selectively activated AMPKα2, which resulted in enhanced mitochondrial biogenesis and potentiated mitophagy, leading to the prevention of hepatic steatosis in obese mice.
3DQRS: A method to obtain reliable QRS complex detection within high field MRI using 12‐lead electrocardiogram traces
Authors: Gregory T. Stan , Schmidt Ehud J. , Zhang Shelley Hualei , Ho Tse Zion Tsz 
Published: January 2014

PurposeTo develop a technique that accurately detects the QRS complex in 1.5 Tesla (T), 3T, and 7T MRI scanners.MethodsDuring early systole, blood is rapidly ejected into the aortic arch, traveling perpendicular to the MRI's main field, which produces a strong voltage (VMHD) that eclipses the QRS complex. Greater complexity arises in arrhythmia patients, since VMHD varies between sinus‐rhythm and arrhythmic beats. The 3DQRS method uses a kernel consisting of 6 electrocardiogram (ECG) precordial leads (V1‐V6), compiled from a 12‐lead ECG performed outside the magnet. The kernel is cross‐correlated with signals acquired inside the MRI to identify the QRS complex in real time. The 3DQRS method was evaluated against a vectorcardiogram (VCG)‐based approach in two premature ventricular contraction (PVC) and two atrial fibrillation (AF) patients, a healthy exercising athlete, and eight healthy volunteers, within 1.5T and 3T MRIs, using a prototype MRI‐conditional 12‐lead ECG system. Two volunteers were recorded at 7T using a Holter recorder.ResultsFor QRS complex detection, 3DQRS subject‐averaged sensitivity levels, relative to VCG were: 1.5T (100% versus 96.7%), 3T (98.9% versus 92.2%), and 7T (96.2% versus 77.7%).ConclusionThe 3DQRS method was shown to be more effective in cardiac gating than a conventional VCG‐based method. Magn Reson Med 71:1374–1380, 2014. © 2014 Wiley Periodicals, Inc.
Muscle intrusion as a potential cause of carpal tunnel syndrome
Authors: Cartwright Michael S. , Walker Francis O. , Newman Jill C. , Arcury Thomas A. , Mora Dana C. , Haiying Chen , Quandt Sara A. 
Published: January 2014

ABSTRACTIntroduction: The aim of this study was to determine whether there is an association between flexor digitorum and lumbrical muscle intrusion into the carpal tunnel and carpal tunnel syndrome (CTS). Methods: Five hundred thirteen manual laborers (1026 wrists) were evaluated with ultrasound to determine whether those with CTS had more muscle intrusion into the carpal tunnel than those without CTS. One hundred ninety of the participants without CTS at baseline (363 wrists) were followed over 1 year to determine whether muscle intrusion at baseline predicted the development of CTS. Results: Participants with CTS had more muscle within the carpal tunnel with the wrist in the neutral (P = 0.026) and flexed (P = 0.018) positions than those without CTS. Baseline muscle intrusion did not predict development of CTS at 1 year. Conclusions: Muscle intrusion into the carpal tunnel is associated with CTS, but muscle intrusion alone does not predict the development of CTS over the course of a year. Muscle Nerve 50: 517–522, 2014