bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tissue-specific regulation of inflammation by macrophage migration inhibitory factor and glucocorticoids in fructose-fed Wistar rats
Authors: Veličković Nataša , Djordjevic Ana , Vasiljević Ana , Bursać Biljana , Milutinović Danijela Vojnović , Matić Gordana 
Published: January 2013

High fructose consumption is commonly associated with insulin resistance, disturbed glucose homeostasis and low-grade inflammation. Increased glucocorticoid production within adipose tissue has been implicated in the pathogenesis of fructose-induced metabolic syndrome. Immunosuppressive actions of glucocorticoids can be counter-regulated by macrophage migration inhibitory factor (MIF), which is recognised as a key molecule in metabolic inflammation. In the present study, we hypothesised that coordinated action of glucocorticoids and MIF can mediate the effects of a high-fructose diet on adipose tissue and liver inflammation. We examined the effects of long-term consumption of a 10 % fructose solution on corticosterone (CORT) and MIF levels in rat blood plasma, liver and adipose tissue, as well as MIF and TNF-α mRNA expression and NF-κB activation in the same tissues. The high-fructose diet led to an increase in both CORT and MIF in the adipose tissue, and a highly significant positive correlation between their levels was observed. The attenuated NF-κB activation and unaltered TNF-α mRNA expression noticed in the adipose tissue could be interpreted as an outcome of the opposing actions of CORT and MIF. In contrast to adipose tissue, inflammation in the liver was characterised by NF-κB activation, an increased TNF-α mRNA level and unchanged levels of MIF protein, MIF mRNA and CORT. Overall, these findings suggest that a high-fructose diet differently affects the levels of glucocorticoids and MIF in the adipose tissue and liver, implicating that fructose over-consumption has tissue-specific effects on regulation of metabolic inflammation.
Polyamines in human breast milk for preterm and term infants
Authors: Plaza-Zamora J. , Sabater-Molina M. , Rodríguez-Palmero M. , Rivero M. , Bosch V. , Nadal J. M. , Zamora S. , Larqué E. 
Published: January 2013

Maternal milk is the first source of exogenous polyamines for the newborn. Polyamines modulate gut maturation in neonates, but no studies are available on polyamine concentration in human milk of preterm babies, even though they could be important for their immature gut. The present study aimed to determine polyamine concentration in human breast milk of mothers with preterm or term infants during the first month of lactation. Human milk samples were obtained during the first month of lactation from twenty-seven mothers with preterm babies and twelve mothers with babies born at term. The polyamine concentration in human milk was quantified by HPLC. During the first month of lactation, the total polyamine concentration was significantly higher in preterm milk than in term milk samples (7590 (sd4990)v.4660 (sd4830) nmol/l, respectively (P =0·034)), as well as individual polyamine concentrations. Polyamine concentration in mature milk for preterm babies was significantly higher than that in mature milk for babies at term, and a similar trend was observed in colostrum and transition human milk. The spermidine/spermine ratio was higher in transition milk in pretermv. term samples, while in mature milk, the ratio was significantly lower in preterm than in term babies. In conclusion, the polyamine concentration was significantly higher in human milk for preterm than for term infants. This and the different spermidine/spermine ratios could influence the gut development of premature babies.
Carboniferous floras in siliciclastic rocks of Kashmir Himalaya, India and the evolutionary history of the Tethyan Basin
Authors: SINGH KAMAL JEET , SINGH RAJINDER , CLEAL CHRISTOPHER J. , SAXENA ANJU , CHANDRA SHAILA 
Published: January 2013

AbstractThe Fenestella Shale Formation of Jammu and Kashmir Himalaya comprises latest Viséan or Serpukhovian siliciclastic deposits formed along the southern margins of the Palaeotethys Ocean. A sequence of shallowing upward and deepening upward units indicates changes from shoreface to offshore and deeper shelf conditions, probably controlled by eustatic changes in an otherwise passive depositional system. Some of the finer-grained, shallow marine deposits have yielded fossil floras dominated by sub-arborescent lycopsids (Sublepidodendron,Lepidodendropsis) sphenophytes (Archaeocalamites) and pteridophylls (Nothorhacopteris,Triphyllopteris). The assemblage compares with other Gondwanan floras of this age that have been assigned to the Paraca floral realm, and are taken to indicate relatively warm climatic conditions that existed just prior to the onset of the Carboniferous–Permian ice-age.
QUEER COUPLINGS: FORMATIONS OF RELIGION AND SEXUALITY IN ʿALAʾ AL-ASWANI'SʿIMARAT YAʿQUBYAN
Authors: Allan Michael 
Published: January 2013

AbstractFaced with the possible censoring of the film adaptation ofʿImarat Yaʿqubyan, the book's author, ʿAlaʾ al-Aswani, responded, “Why aren't Italy, France, or the United States defamed by movies dealing with homosexuality?” Implicit in his defensive question is a perceived distinction between First World gay rights and social conservatism in the Third World. My paper considers this conventional coupling of gay rights and civilizational discourse in the global reception ofʿImarat Yaʿqubyan. Against the author's remarks, I argue that the story is remarkable for staging an interplay between the putatively opposed characters of Hatim Rashid, an openly gay newspaper editor, and Taha al-Shazli, a young man lured into a terrorist group. By uniting these two characters along parallel tracks,ʿImarat Yaʿqubyanqueerly couples the seemingly antagonistic forces endemic to the civilizational discourse of gay rights and offers us a means for imagining new constellations of queer politics.
MAJNUN STRIKES BACK: CROSSINGS OF MADNESS AND HOMOSEXUALITY IN CONTEMPORARY ARABIC LITERATURE
Authors: El-Ariss Tarek 
Published: January 2013

AbstractThis article examines the association of homosexuality with madness in two contemporary novels, Hanan al-Shaykh'sInnaha London ya ʿAzizi(Only in London) and Hamdi Abu Golayyel's (Julayyil)Lusus Mutaqaʿidun(Thieves in Retirement). Through a comparative reading of the figure of Majnun, an impassioned lover and mad rebel, I argue that literary articulations of queer desire operate as embodied resistance to social and political normativity, both in the Arab world and in the diaspora. Discussing the aesthetic transformation of the contemporary novel and drawing on the Arab-Islamic literary and philosophical tradition, I critically engage Michel Foucault's reading of sexual and epistemological developments in light of current debates about Arab homosexuality. I show how discursive models of sexuality are situated in modernity's intertwinement with other structures of power and systems of belief, crossing cultural contexts and linguistic registers.
Climate variability and change in the Central Rift Valley of Ethiopia: challenges for rainfed crop production
Authors: KASSIE B. T. , RÖTTER R. P. , HENGSDIJK H. , ASSENG S. , VAN ITTERSUM M. K. , KAHILUOTO H. , VAN KEULEN H. 
Published: January 2013

SUMMARYEthiopia is one of the countries most vulnerable to the impacts of climate variability and change on agriculture. The present study aims to understand and characterize agro-climatic variability and changes and associated risks with respect to implications for rainfed crop production in the Central Rift Valley (CRV). Temporal variability and extreme values of selected rainfall and temperature indices were analysed and trends were evaluated using Sen's slope estimator and Mann–Kendall trend test methods. Projected future changes in rainfall and temperature for the 2080s relative to the 1971–90 baseline period were determined based on four General Circulation Models (GCMs) and two emission scenarios (SRES, A2 and B1). The analysis for current climate showed that in the short rainy season (March–May), total mean rainfall varies spatially from 178 to 358 mm with a coefficient of variation (CV) of 32–50%. In the main (long) rainy season (June–September), total mean rainfall ranges between 420 and 680 mm with a CV of 15–40%. During the period 1977–2007, total rainfall decreased but not significantly. Also, there was a decrease in the number of rainy days associated with an increase (statistically not significant) in the intensity per rainfall event for the main rainy season, which can have implications for soil and nutrient losses through erosion and run-off. The reduced number of rainy days increased the length of intermediate dry spells by 0·8 days per decade, leading to crop moisture stress during the growing season. There was also a large inter-annual variability in the length of growing season, ranging from 76 to 239 days. The mean annual temperature exhibited a significant warming trend of 0·12–0·54 °C per decade. Projections from GCMs suggest that future annual rainfall will change by +10 to −40% by 2080. Rainfall will increase during November–December (outside the growing season), but will decline during the growing seasons. Also, the length of the growing season is expected to be reduced by 12–35%. The annual mean temperature is expected to increase in the range of 1·4–4·1 °C by 2080. The past and future climate trends, especially in terms of rainfall and its variability, pose major risks to rainfed agriculture. Specific adaptation strategies are needed for the CRV to cope with the risks, sustain farming and improve food security.
Solving the Return Deviation Conundrum of Leveraged Exchange-Traded Funds
Authors: Tang Hongfei , Xu Xiaoqing Eleanor 
Published: January 2013

AbstractThe large deviation of the actual return of a leveraged exchange-traded fund (LETF) from the leveraged multiple of the underlying index return has drawn considerable attention from investors, regulators, and the financial media. Despite this attention, the sources and fundamental determinants of the LETF return deviation remain unidentified. This study constructs a clear, unified, objective, and executable framework that addresses the behaviors, sources, and determinants of the LETF compounding and noncompounding deviations. Our theoretical predictions and empirical results hold the promise of guiding investors, regulators, financial advisors, and portfolio managers toward a thorough understanding of the return behavior of LETFs.
Differential association between circulating testosterone and infection risk by several viruses in natural cat populations: a behavioural-mediated effect?
Authors: HELLARD E. , FOUCHET D. , REY B. , MOUCHET A. , POULET H. , PONTIER D. 
Published: January 2013

SUMMARYTestosterone is involved in the development and expression of physiological, morphological and behavioural traits. High levels are often associated with high infection risk and/or intensity, suggesting a trade-off between sexual traits and immunity. Classically invoked mechanisms are immunological or behavioural, i.e., testosterone increases susceptibility or resistance to parasites via an impact on immunity or modulates behaviours involved in parasite transmission. However, studies report contrasted patterns. Given its modes of action and the diversity of host-parasite interactions, testosterone should not act similarly on all interactions. To reduce host and context diversity, we studied 3 viruses in the same cat population: the aggressively transmitted Feline Immunodeficiency virus (FIV), and the Feline Calicivirus (FCV) and Herpesvirus (FHV) both transmitted during friendly contacts. Testosterone had a strong effect on the probability of being positive to FIV whereas its effect was significantly weaker on FCV and FHV. These findings demonstrate that testosterone can be differentially associated with parasites of the same type (viruses). The difference we observed was consistent with a behavioural-mediated effect (increased aggressiveness), supporting the idea that the testosterone effect on infection risk is at least partially driven by behavioural mechanisms in our system. Further investigations (e.g., individual immunity measures) are required to confirm this hypothesis.
Babesia bovis:lipids from virulent S2P and attenuated R1A strains trigger differential signalling and inflammatory responses in bovine macrophages
Authors: GIMENEZ G. , BELAUNZARÁN M. L. , PONCINI C. V. , BLANCO F. C. , ECHAIDE I. , ZAMORANO P. I. , LAMMEL E. M. , GONZÁLEZ CAPPA S. M. , ISOLA E. L. D. 
Published: January 2013

SUMMARYThe intra-erythrocytic protozoanBabesia bovisis an economically important pathogen that causes an acute and often fatal infection in adult cattle. Babesiosis limitation depends on the early activation of macrophages, essential cells of the host innate immunity, which can generate an inflammatory response mediated by cytokines and nitric oxide (NO). Herein, we demonstrate in bovine macrophages that lipids fromB. bovisattenuated R1A strain (LA) produced a stronger NO release, an early TNFαmRNA induction and 2-fold higher IL-12p35 mRNA levels compared to the lipids of virulent S2P strain (LV). Neither LAnor LVinduced anti-inflammatory IL-10. Regarding signalling pathways, we here report that LAinduced a significant phosphorylation of p38 and extracellular signal-regulated kinases 1 and 2 (ERK1/2) whereas LVonly induced a reduced activation of ERK1/2. Besides, NF-κB was activated by LAand LV, but LAproduced an early degradation of the inhibitor IκB. Interestingly, LVand the majority of its lipid fractions, exerted a significant inhibition of concanavalin A-induced peripheral blood mononuclear cell proliferation with respect to LAand its corresponding lipid fractions. In addition, we determined that animals infected with R1A developed a higher increase in IgM anti-phosphatidylcholine than those inoculated with S2P. Collectively, S2P lipids generated a decreased inflammatory response contributing to the evasion of innate immunity. Moreover, since R1A lipids induced a pro-inflammatory profile, we propose these molecules as good candidates for immunoprophylactic strategies against babesiosis.
“The Brightest Sun, The Darkest Shadow”: Ideology and the Study of Chinese Theatre in the West during the Cold War
Authors: Liu Siyuan 
Published: January 2013

This is the new Communist drama, and the picture is frequently artless and sterile, without depth, without truth, and without reality.—Walter and Ruth Meserve, 1970Peking opera now is a mixture of drama, music, dance, acrobatics, poetry, propaganda and revolutionary history, with indefatigable heroes (more adroit than James Bond, and with a purpose he never dreamed of) and fabulously wicked villains—the whole socking out a message of exemplary struggle and courage.—Lois Wheeler Snow, 1972The study of Asian theatre as an academic field independent of English and Asian Studies arose in the West, particularly the United States, after World War II, in part as a result of the U.S. occupation of Japan and cold war–era funding policies aimed at spreading democracy in Asia. The notable exception was research on theatre in the People's Republic of China (PRC), which was restrained by the McCarthyist Red Scare, which greatly constricted China studies, and the PRC's self-imposed closure to the West, which made field and archival research virtually impossible. However, these conditions changed dramatically in the early and mid-1970s when the combined effect of China's midcourse correction during the Cultural Revolution (1966–76) and Nixon's 1972 trip to China prompted a small boom in the translation, publication, reporting, and research of Chinese plays and performance. At the same time, as the two epigraphs above indicate, this first group of writings on Chinese theatre was made largely problematic by a number of factors: the inherently ideological nature of Chinese theatre during the Cultural Revolution; the diverse ideological, academic, and theatrical background of the authors working on the subject during a similarly volatile era in the West; an overreliance on official Chinese publications (usually as the only source available); and restricted access to China for all but a small number of Westerners. Although insightful and well-researched writings certainly existed, much of this body of work reflects the ideological preoccupations of Euro-American intellectuals in the cold war era. The latter manifested themselves either through oversimplified condemnation of communist theatre as artless propaganda or through radical leftist eulogy of China's supposed success in combining theatre and ideology, making theatre serve the people, and promoting amateur performance to stimulate production.
Cost-effectiveness of interferon-gamma release assay for entry tuberculosis screening in prisons
Authors: KOWADA A. 
Published: January 2013

SUMMARYThe incidence of active tuberculosis (TB) and latent tuberculosis infection (LTBI) in inmates and prison staff is higher than that in the general population. Mycobacterium tuberculosis-specific interferon-gamma release assays (IGRAs) provide more accurate diagnosis of M. tuberculosis infection with higher specificity than the tuberculin skin test (TST). To assess the cost-effectiveness of QuantiFERON®-TB Gold In-Tube (QFT) compared to TST, TST followed by QFT and chest X-ray, we constructed Markov models using a societal perspective on the lifetime horizon. The main outcome measure of effectiveness was quality-adjusted life-years (QALYs) gained. The incremental cost-effectiveness was compared. The QFT-alone strategy was the most cost-effective for entry TB screening in prisons in developed countries. Cost-effectiveness was not sensitive to the rates of BCG vaccination, LTBI, TB, HIV infection and multidrug-resistant TB. Entry TB screening using an IGRA in prisons should be considered on the basis of its cost-effectiveness by public health intervention.
(–)-Epicatechin is associated with increased angiogenic and mitochondrial signalling in the hindlimb of rats selectively bred for innate low running capacity
Authors: Hüttemann Maik , Lee Icksoo , Perkins Guy A. , Britton Steven L. , Koch Lauren G. , Malek Moh H. 
Published: January 2013

Alternative approaches to reduce congenital muscle dysfunction are needed in cases where the ability to exercise is limited. (−)-Epicatechin is found in cocoa and may stimulate capillarity and mitochondrial proliferation in skeletal muscle. A total of 21 male rats bred for LCR (low running capacity) from generation 28 were randomized into three groups: vehicle for 30 days (control); (−)-epicatechin for 30 days; and (−)-epicatechin for 30 days followed by 15 days without (−)-epicatechin. Groups 2 and 3 received 1.0 mg of (−)-epicatechin/kg of body mass twice daily, whereas water was given to the control group. The plantaris muscle was harvested for protein and morphometric analyses. In addition, in vitro experiments were conducted to examine the role of (−)-epicatechin on mitochondrial respiratory kinetics at different incubation periods. Treatment for 30 days with (−)-epicatechin increased capillarity (P&lt;0.001) and was associated with increases in protein expression of VEGF (vascular endothelial growth factor)-A with a concomitant decrease in TSP-1 (thrombospondin-1) and its receptor, which remained after 15 days of (−)-epicatechin cessation. Analyses of the p38 MAPK (mitogen-activated protein kinase) signalling pathway indicated an associated increase in phosphorylation of MKK3/6 (MAPK kinase 3/6) and p38 and increased protein expression of MEF2A (myocyte enhancer factor 2A). In addition, we observed significant increases in protein expression of PGC-1α (peroxisome-proliferator-activated receptor γ co-activator 1α), PGC-1β, Tfam and cristae abundance. Interestingly, these increases associated with (−)-epicatechin treatment remained after 15 days of cessation. Lastly, in vitro experiments indicated that acute exposure of LCR muscle to (−)-epicatechin incubation was not sufficient to increase mitochondrial respiration. The results suggest that increases in skeletal muscle capillarity and mitochondrial biogenesis are associated with 30 days of (−)-epicatechin treatment and sustained for 15 days following cessation of treatment. Clinically, the use of this natural compound may have potential application in populations that experience muscle fatigue and are unable to perform endurance exercise.
Strain Differences in Cortical Electroencephalogram Associated with Isoflurane-induced Loss of Consciousness
Authors: McCallum J. Bruce , Pillay Siveshigan , Vizuete Jeannette A. , Mouradian Gary , Hudetz Anthony G. , Stekiel Thomas A. 
Published: January 2013

Abstract

Introduction:
Previously observed increased sensitivity to noxious stimulation in the Dahl salt-sensitive rat strain (SS/JrHsdMcwi, abbreviated as SS) compared to Brown Norway rats (BN/NhsdMcwi abbreviated as BN) is mediated by genes on a single chromosome. The current study used behavioral and electrocortical data to determine if differences also exist between SS and BN rats in loss of consciousness.

Methods:
Behavioral responses, including loss of righting, (a putative index of consciousness) and concurrent electroencephalogram recordings, in 12 SS and BN rats were measured during isoflurane at inhaled concentrations of 0, 0.3, 0.6, 0.8, 1.0 and 1.2%.

Results:
In SS compared to BN rats, the mean ± SEM EC50 for righting was significantly less (0.65 ± 0.01% vs. 0.74 ± 0.02% inhaled isoflurane) and delta fraction in parietal electroencephalogram was enhanced 50–100% at all isoflurane levels during emergence. The frequency decay constant of an exponential fit of the parietal electroencephalogram spectrum graphed as a function of isoflurane level was three times less steep (mean ± SEM slope −57 ± 13 vs. −191 ± 38) and lower at each level of isoflurane in SS versus BN rats (i.e., shifted toward low frequency activity). Electroencephalogram differences between strains were larger during emergence than induction.

Conclusions:
Sensitivity is higher in SS compared to BN rats leading to unconsciousness at lower levels of isoflurane. This supports using additional strains in this animal model to study the genetic basis for differences in anesthetic action on mechanisms of consciousness. Moreover, induction and emergence appear to involve distinct pathways.
Psychosocial Issues in Pediatric Inflammatory Bowel Disease
Authors: Mackner Laura M. , Greenley Rachel Neff , Szigethy Eva , Herzer Michele , Deer Kate , Hommel Kevin A. 
Published: January 2013

ABSTRACTPediatric inflammatory bowel disease (IBD) can affect many areas of psychosocial functioning, and comprehensive medical care includes consideration of psychosocial issues as well as disease factors. The purpose of this clinical report is to review research on psychosocial functioning in pediatric IBD and to provide recommendations for care providers in the areas of psychopathology, health‐related quality of life, and social, family, and school functioning. Youth with IBD are at increased risk for difficulty in all areas reviewed, and many psychosocial factors are associated with disease activity, which highlights the importance of monitoring psychosocial functioning as part of clinical care. Several interventions have empirical support or show promise for addressing psychosocial difficulty, and recommendations for monitoring and treating these issues are provided.