bluuebunny/crossref_metadata_2025_split huggingface dataset:
Extracorporeal clearance of colistin methanesulphonate and formed colistin in end-stage renal disease patients receiving intermittent haemodialysis: implications for dosing
Authors: Jitmuang Anupop , Nation Roger L. , Koomanachai Pornpan , Chen Gong , Lee Hee Ji , Wasuwattakul Somkiat , Sritippayawan Suchai , Li Jian , Thamlikitkul Visanu , Landersdorfer Cornelia B. 
Published: February 2015

Abstract

Objectives
Colistin, administered intravenously as its inactive prodrug colistin methanesulphonate (CMS), is being increasingly used. However, there is very limited information available on the impact of haemodialysis (HD) on the pharmacokinetics of CMS and formed colistin.

Patients and methods
A single 30 min intravenous dose of CMS (150 mg of colistin base activity) was administered to 10 patients undergoing HD. HD was performed from 1.5 to 5.5 h after the start of the CMS infusion. Serial blood samples were collected over 50 h, additional blood samples pre- and post-dialysis membrane at three timepoints during HD, dialysate samples at four timepoints during HD, and a cumulative urine sample over 24 h. CMS and colistin were determined by HPLC. Population modelling and determination of HD clearance by multiple methods was conducted.

Results
The average amount of CMS recovered in the dialysate was 30.6% of the dose administered. The concentrations of CMS and colistin in the plasma and the amounts of CMS recovered in the dialysate were well described by the population disposition model. The clearance of CMS by dialysis as estimated by population analysis based on systemic plasma concentrations and amounts in the dialysate was 4.26 L/h (26% coefficient of variation). The dialysis clearance determined from the pre- and post-membrane plasma concentrations was 5.67 L/h (21%) for CMS and 3.99 L/h (44%) for colistin. Thus, CMS clearance by dialysis from trans-cartridge extraction was ∼30% higher than when calculated based on the amount in dialysate, suggesting adsorption to the membrane.

Conclusions
Due to the extensive removal of CMS by dialysis, HD should be conducted at the end of a dosing interval and a supplemental dose should be administered.
Incident Hepatitis C Virus Infections in the Swiss HIV Cohort Study: Changes in Treatment Uptake and Outcomes Between 1991 and 2013
Authors: Wandeler Gilles , Schlauri Marion , Jaquier Marie-Eve , Rohrbach Janine , Metzner Karin J. , Fehr Jan , Ambrosioni Juan , Cavassini Matthias , Stöckle Marcel , Schmid Patrick , Bernasconi Enos , Keiser Olivia , Salazar-Vizcaya Luisa , Furrer Hansjakob , Rauch Andri ,   The Swiss HIV Cohort Study, Aubert V. , Battegay M. , Bernasconi E. , Böni J. , Bucher H.C. , Burton-Jeangros C. , Calmy A. , Cavassini M. , Dollenmaier G. , Egger M. , Elzi L. , Fehr J. , Fellay J. , Furrer H. , Fux C.A. , Gorgievski M. , Günthard H. , Haerry D. , Hasse B. , Hirsch H.H. , Hoffmann M. , Hösli I. , Kahlert C. , Kaiser L. , Keiser O. , Klimkait T. , Kouyos R. , Kovari H. , Ledergerber B. , Martinetti G. , Martinez de Tejada B. , Metzner K. , Müller N. , Nadal D. , Nicca D. , Pantaleo G. , Rauch A. , Regenass S. , Rickenbach M. , Rudin C. , Schöni-Affolter F. , Schmid P. , Schüpbach J. , Speck R. , Tarr P. , Telenti A. , Trkola A. , Vernazza P. , Weber R. , Yerly S. 
Published: February 2015

Abstract
Background.  The hepatitis C virus (HCV) epidemic is evolving rapidly in patients infected with human immunodeficiency virus (HIV). We aimed to describe changes in treatment uptake and outcomes of incident HCV infections before and after 2006, the time-point at which major changes in HCV epidemic became apparent.
Methods.  We included all adults with an incident HCV infection before June 2012 in the Swiss HIV Cohort Study, a prospective nationwide representative cohort of individuals infected with HIV. We assessed the following outcomes by time period: the proportion of patients starting an HCV therapy, the proportion of treated patients achieving a sustained virological response (SVR), and the proportion of patients with persistent HCV infection during follow-up.
Results.  Of 193 patients with an HCV seroconversion, 106 were diagnosed before and 87 after January 2006. The proportion of men who have sex with men increased from 24% before to 85% after 2006 (P &lt; .001). Hepatitis C virus treatment uptake increased from 33% before 2006 to 77% after 2006 (P &lt; .001). Treatment was started during early infection in 22% of patients before and 91% after 2006 (P &lt; .001). An SVR was achieved in 78% and 29% (P = .01) of patients treated during early and chronic HCV infection. The probability of having a detectable viral load 5 years after diagnosis was 0.67 (95% confidence interval [CI], 0.58–0.77) in the group diagnosed before 2006 and 0.24 (95% CI, 0.16–0.35) in the other group (P &lt; .001).
Conclusions.  In recent years, increased uptake and earlier initiation of HCV therapy among patients with incident infections significantly reduced the proportion of patients with replicating HCV.
The Efficacy of Adjuvant Chemotherapy in Patients With Stage II/III Resected Rectal Cancer Treated With Neoadjuvant Chemoradiation Therapy
Authors: Ahn Daniel H. , Wu Christina , Wei Lai , Williams Terence M. , Wuthrick Evan , Abdel-Misih Sherif , Harzman Alan , Husain Syed , Schmidt Carl , Goldberg Richard M. , Bekaii-Saab Tanios 
Published: February 2015

Introduction:
Patients with stage II/III rectal cancers are treated with neoadjuvant chemoradiation and surgical resection followed by adjuvant chemotherapy (CT) per practice guidelines. It is unclear whether adjuvant CT provides survival benefit, and the purpose of this study was to measure outcomes in patients who did and did not receive adjuvant CT.

Materials and Methods:
We used a prospectively collected database for patients treated at The Ohio State University, and analyzed overall survival (OS), time to recurrence, patient characteristics, tumor features, and treatments. Survival curves were estimated using Kaplan-Meier method and compared by the log-rank test. Age was compared using the Wilcoxon test, and other categorical variables were compared using the χ2 or Fisher exact test.

Results:
Between August 2005 and July 2011, 110 patients were identified and 71 patients had received adjuvant CT. There was no significant difference in sex, race, pathologic tumor stage, and pathologic complete response between the 2 patient groups. Although patient characteristics showed a difference in age (median age 54.3 vs. 62 y, P=0.01) and advanced pathologic nodal status (43% vs. 19%, P=0.02), there was a significant difference in OS. Median OS was 72.6 months with CT versus 36.4 months without CT (P=0.0003). Median time to recurrence has not yet been reached.

Conclusions:
In this retrospective analysis, adjuvant CT was associated with a longer OS despite more advanced pathologic nodal staging. Prospective randomized studies are warranted to determine whether adjuvant CT provides a survival benefit for patients across the spectrum of stage II and III rectal cancer.
Engineering Transcriptional Regulator Effector Specificity using Computational Design and In Vitro Rapid Prototyping: Developing a Vanillin Sensor
Authors: de los Santos Emmanuel L. C. , Meyerowitz Joseph T. , Mayo Stephen L. , Murray Richard M. 
Published: February 2015

AbstractThe pursuit of circuits and metabolic pathways of increasing complexity and ro-bustness in synthetic biology will require engineering new regulatory tools. Feedback control based on relevant molecules, including toxic intermediates and environmental signals, would enable genetic circuits to react appropriately to changing conditions. In this work, variants of qacR, a tetR family repressor, were generated by computational protein design and screened in a cell-free transcription-translation (TX-TL) system for responsiveness to a new targeted effector. The modified repressors target vanillin, a growth-inhibiting small molecule found in lignocellulosic hydrolysates and other industrial processes. Promising candidates from thein vitroscreen were further characterizedin vitroandin vivoin a gene circuit. The screen yielded two qacR mutants that respond to vanillin bothin vitroandin vivo. We believe this process, a combination of the generation of variants coupled within vitroscreening, can serve as a framework for designing new sensors for other target compounds.
Differential Evolution Approach to Detect Recent Admixture
Authors: Kozlov Konstantin , Chebotarov Dmitry , Hassan Mehedi , Triska Martin , Triska Petr , Flegontov Pavel , Tatarinova Tatiana 
Published: February 2015

AbstractThe genetic structure of human populations is extraordinarily complex and of fundamental importance to studies of anthropology, evolution, and medicine. As increasingly many individuals are of mixed origin, there is an unmet need for tools that can infer multiple origins. Misclassification of such individuals can lead to incorrect and costly misinterpretations of genomic data, primarily in disease studies and drug trials. We present an advanced tool to infer ancestry that can identify the biogeographic origins of highly mixed individuals.reAdmixcan incorporate individual’s knowledge of ancestors (e.g. having some ancestors from Turkey or a Scottish grandmother).reAdmixis an online tool available athttp://chcb.saban-chla.usc.edu/reAdmix/.
SHAPE directed RNA folding
Authors: Luntzer Dominik , Lorenz Ronny , Hofacker Ivo L. , Stadler Peter F. , Wolfinger Michael T. 
Published: February 2015

AbstractSummaryChemical mapping experiments allow for nucleotide resolution assessment of RNA structure. We demonstrate that different strategies of integrating probing data with thermodynamics-based RNA secondary structure prediction algorithms can be implemented by means of soft constraints. This amounts to incorporating suitable pseudo-energies into the standard energy model for RNA secondary structures. As a showcase application for this new feature of theviennaRNA Packagewe compare three distinct, previously published strategies to utilize SHAPE reactivities for structure prediction. The new tool is benchmarked on a set of RNAs with known reference structure.Availability and implementationThe capability for SHAPE directed RNA folding is part of the upcoming release of theviennaRNA Package 2.2, for which a preliminary release is already freely available athttp://www.tbi.univie.ac.at/RNA.Contactmichael.wolfinger@univie.ac.atSupplementary informationSupplementary data is attached.
Small Glycosylated Lignin Oligomers Are Stored in Arabidopsis Leaf Vacuoles
Authors: Dima Oana , Morreel Kris , Vanholme Bartel , Kim Hoon , Ralph John , Boerjan Wout 
Published: February 2015

Abstract
Lignin is an aromatic polymer derived from the combinatorial coupling of monolignol radicals in the cell wall. Recently, various glycosylated lignin oligomers have been revealed in Arabidopsis thaliana. Given that monolignol oxidation and monolignol radical coupling are known to occur in the apoplast, and glycosylation in the cytoplasm, it raises questions about the subcellular localization of glycosylated lignin oligomer biosynthesis and their storage. By metabolite profiling of Arabidopsis leaf vacuoles, we show that the leaf vacuole stores a large number of these small glycosylated lignin oligomers. Their structural variety and the incorporation of alternative monomers, as observed in Arabidopsis mutants with altered monolignol biosynthesis, indicate that they are all formed by combinatorial radical coupling. In contrast to the common believe that combinatorial coupling is restricted to the apoplast, we hypothesized that the aglycones of these compounds are made within the cell. To investigate this, leaf protoplast cultures were cofed with 13C6-labeled coniferyl alcohol and a 13C4-labeled dimer of coniferyl alcohol. Metabolite profiling of the cofed protoplasts provided strong support for the occurrence of intracellular monolignol coupling. We therefore propose a metabolic pathway involving intracellular combinatorial coupling of monolignol radicals, followed by oligomer glycosylation and vacuolar import, which shares characteristics with both lignin and lignan biosynthesis.
A Chaperone Function of NO CATALASE ACTIVITY1 Is Required to Maintain Catalase Activity and for Multiple Stress Responses in Arabidopsis
Authors: Li Jing , Liu Juntao , Wang Guoqiang , Cha Joon-Yung , Li Guannan , Chen She , Li Zhen , Guo Jinghua , Zhang Caiguo , Yang Yongqing , Kim Woe-Yeon , Yun Dae-Jin , Schumaker Karen S. , Chen Zhongzhou , Guo Yan 
Published: February 2015

Abstract
Catalases are key regulators of reactive oxygen species homeostasis in plant cells. However, the regulation of catalase activity is not well understood. In this study, we isolated an Arabidopsis thaliana mutant, no catalase activity1-3 (nca1-3) that is hypersensitive to many abiotic stress treatments. The mutated gene was identified by map-based cloning as NCA1, which encodes a protein containing an N-terminal RING-finger domain and a C-terminal tetratricopeptide repeat-like helical domain. NCA1 interacts with and increases catalase activity maximally in a 240-kD complex in planta. In vitro, NCA1 interacts with CATALASE2 (CAT2) in a 1:1 molar ratio, and the NCA1 C terminus is essential for this interaction. CAT2 activity increased 10-fold in the presence of NCA1, and zinc ion binding of the NCA1 N terminus is required for this increase. NCA1 has chaperone protein activity that may maintain the folding of catalase in a functional state. NCA1 is a cytosol-located protein. Expression of NCA1 in the mitochondrion of the nca1-3 mutant does not rescue the abiotic stress phenotypes of the mutant, while expression in the cytosol or peroxisome does. Our results suggest that NCA1 is essential for catalase activity.
Editorial
Authors: Ogliastri Enrique 
Published: February 2015

Abstract
This issue includes six articles from ten universities in Chile, Colombia and Spain. The subjects are on entrepreneurship, public administration, management of intellectual capital marketing and also the immediate rejection policies of the journal's editor. The first study identifies different models of support programs in creating technology-based companies (spin‐offs) in universities from Spain and Great Britain, and the factors that determine their efficiency. The second one is on that factors that lead a person to entrepreneurship, particularly the impact of gender and the sociocultural aspects in regional entrepreneurships of Chile. The third studies the continuity of the entrepreneurial spirit in university students many years after graduating. The fourth makes an evaluation of the service portals available to the citizens of 19 countries in Latin America. The fifth is a study of the nets of scientific collaboration of the most prestigious Latin American business schools. The sixth is a study on the market orientation and obtained results in the business of rural tourism. An Editorial also deals with the criteria for immediate rejection of articles received by the journal. We plan a special issue on culture and art management, associated with the EURAM conference.

Resumen
Este número incluye seis artículos provenientes de diez universidades de Chile, Colombia y España, sobre emprendimiento, administración pública, gestión del capital intelectual y mercadeo, así como la política de rechazo inmediato del editor de la revista. El primer estudio identifica diferentes modelos de programas de apoyo a la creación de empresas con base tecnológica (spin‐offs) en universidades de España y Gran Bretaña, y los factores que determinan su eficacia. El segundo sobre factores que llevan a una persona a emprender, en particular el impacto del género y aspectos socioculturales en los emprendimientos regionales en Chile. El tercero estudia la continuidad del espíritu empresarial de los universitarios varios años después de graduarse. El cuarto realiza una evaluación de los portales de servicio al ciudadano en 19 países de América Latina. El quinto es un estudio de las redes de colaboración científica de las escuelas de negocios más prestigiosas de América Latina. El sexto es un estudio sobre la orientación al mercado y los resultados obtenidos en el negocio de pequeñas firmas de servicios de turismo rural. Un Editorial trata sobre los criterios para rechazo inmediato de artículos recibidos en la revista. Planeamos un número especial sobre la gestión cultural y de arte, asociada a la conferencia de EURAM.
Empirical study of measuring supply chain performance
Authors: Sillanpää Ilkka 
Published: February 2015

Purpose
– Supply chain (SC) performance measurement – the process of qualifying the efficiency and effectiveness of the SC. The purpose of this paper is to create a SC measurement framework for manufacturing industry, define which data should be measured and verify the measurement framework in the case company’s SC.

Design/methodology/approach
– There is a review of the current understanding of supply chain management and literature related to SC performance measurement and the study creates a framework for SC measurement. This research is qualitative case study research.

Findings
– This study presents the main theoretical framework of SC performance measurement. The key elements for the measurement framework were defined as time, profitability, order book analysis and managerial analysis. The measurement framework is tested by measuring case SC performance.

Research limitations/implications
– In the study, a performance measurement framework was created for the needs of manufacturing industry. Suggestions for future research are multiple case study in different manufacturing industry areas and positivistic-based SC performance research.

Practical implications
– The measurement framework in this study offers guidelines for measuring the SC in manufacturing industry but the measurement framework could be used in different areas of industry as well.

Originality/value
– The SC performance measurement framework is tested and a valid framework for SC performance measurement in manufacturing industry.
Applications of benchmarking and classification framework for supplier risk management
Authors: Phusavat Kongkiti , Anussornnitisarn Pornthep , Pongrakhananon Tatchapan , Pastuszak Zbigniew 
Published: February 2015

Purpose
– The purpose of this paper is to develop a supplier risk framework. The framework provides the information about the risk level in which a supplier is classified. This study is part of the company’s one- department-one-improvement policy. This policy encourages all departments to look for way to improve process management. For this study, the Purchasing Department attempts to extend its supplier management practices by integrating the risk consideration.

Design/methodology/approach
– This work is considered as a case study. The study integrates the benchmarking and classification concepts for this extension. The involvement from the company’s purchasing department is critical. There are several steps that have been undertaken. Included are the selection of the supplies to be considered (i.e. packaging), the analysis of the formal complaints by the ratio-format indicator, the four criteria used for the classification, the risk level identification, and the next steps for improving supplier management. The results are verified by the use of cluster analysis. The data are from departmental staffs and manager.

Findings
– Based on the results, with the four agreed criteria (e.g. regional location, ownership type, joint venture, and registered capital and size), there are altogether four risk levels which are high, medium, low, and minimal.. For the packaging materials, most suppliers belong to the low and minimal risk levels (or 19 out of 27 suppliers). Future activities are then developed and added into the company’s ISO 9001: 2008 manual.

Practical implications
– The suppliers’ risk levels with corresponding future actions represent positive contributions to the purchasing department. Integrating supplier risk is based on the applications of benchmarking (i.e. the use of the ratio-format indicators) and classification (i.e. the need to understand the nature of the risk level) frameworks. Future actions to mitigate the risk are also proposed and incorporated into the purchasing department’s procedure.

Originality/value
– The project underlines the roles and importance of benchmarking in strengthening the supplier management processes. It also highlights the practicality and benefits of benchmarking when linking with the classification concept for addressing today business problems.
Domestic abuse victims’ perceptions of abuse and support: a narrative study
Authors: Spruin Elizabeth , Alleyne Emma , Papadaki Ioanna 
Published: February 2015

Purpose– While there is a large body of research exploring the various avenues of support for domestic abuse victims and the risk factors which put women at risk of victimization, there is little research exploring the perceptions of these women. The purpose of this paper is therefore to explore the personal views of victimized women; in particular, the risk factors that they believe put them at risk for abuse and what they feel support services should offer.Design/methodology/approach– In total, 12 women were interviewed about their experiences of domestic violence. Interviews were analyzed using thematic analysis which resulted in three themes: first intimate relationship; quality of life; and supporting services.Findings– The results from the analysis highlighted some prominent risk factors and, most importantly, emphasized the need for alternative forms of support. Overall, the findings provide an innovative way of viewing domestic violence by understanding it through victim ' s narratives, which can further aid to inform current support services within the UK and elsewhere.Research limitations/implications– The quality of life around the time of abuse is a factor that should be explored further in relation to the victimization of women.Practical implications– Ambivalent first sexual encounters may be an important risk factor for future relationship violence.Social implications– Support services for domestically abused women need to offer more internal support for vocational and educational services.Originality/value– There is little research exploring the personal views and perceptions of victimized women, in particular, the risk factors that they believe put them at risk for domestic abuse and what they feel support services should offer. The value of this research is therefore founded in the exploring this gap in literature and provide victims with a voice to aid researchers in understanding domestic abuse from another perspective. Investigating a victim ' s personal account is one pathway into beginning to understand the underlying thought processes and beliefs they attach to an event. If themes within a personal narrative account could be identified within victims of domestic abuse, it may allow a new aetiological perspective to develop in regard to the understanding and needs of abused women.
Housing Prices in Urban China as Determined by Demand and Supply
Authors: Chow Gregory C. , Niu Linlin 
Published: February 2015

AbstractThis paper studies the demand for and supply of residential housing in urban China since the late 1980s when the urban housing market became commercialized. Using aggregated annual data from 1987 to 2012 in a simultaneous equations framework we show that the rapid increase in the urban residential housing price can be well explained by the forces of demand and supply, with income determining demand and cost of construction affecting supply. We find the income elasticity of demand for urban housing to be approximately 1, the price elasticity of demand to be approximately −1.1 and the price elasticity of supply of the total housing stock to be approximately 0.5. The resulting long‐run effect of income on urban housing prices in elasticity terms is approximately 0.7, because the increase in income has shifted the demand curve outward more rapidly than the supply curve.