bluuebunny/crossref_metadata_2025_split huggingface dataset:
Networking the host immune response in Plasmodium vivax malaria
Authors: Mendonça Vitor RR , Queiroz Artur TL , Lopes Fabrício M , Andrade Bruno B , Barral-Netto Manoel 
Published: February 2013

AbstractBackgroundPlasmodium vivaxmalaria clinical outcomes are a consequence of the interaction of multiple parasite, environmental and host factors. The host molecular and genetic determinants driving susceptibility to disease severity in this infection are largely unknown. Here, a network analysis of large-scale data from a significant number of individuals with different clinical presentations ofP. vivaxmalaria was performed in an attempt to identify patterns of association between various candidate biomarkers and the clinical outcomes.MethodsA retrospective analysis of 530 individuals from the Brazilian Amazon, includingP. vivax-infected individuals who developed different clinical outcomes (148 asymptomatic malaria, 187 symptomatic malaria, 13 severe non-lethal malaria, and six severe lethal malaria) as well as 176 non-infected controls, was performed. Plasma levels of liver transaminases, bilirubins, creatinine, fibrinogen, C-reactive protein, superoxide dismutase (SOD)-1, haem oxygenase (HO)-1 and a panel composed by multiple cytokines and chemokines were measured and compared between the different clinical groups using network analysis.ResultsNon-infected individuals displayed several statistically significant interactions in the networks, including associations between the levels of IL-10 and IL-4 with the chemokine CXCL9. Individuals with asymptomatic malaria displayed multiple significant interactions involving IL-4. Subjects with mild or severe non-lethal malaria displayed substantial loss of interactions in the networks and TNF had significant associations more frequently with other parameters. Cases of lethalP. vivaxmalaria infection were associated with significant interactions between TNF ALT, HO-1 and SOD-1.ConclusionsThe findings imply that clinical immunity toP. vivaxmalaria is associated with multiple significant interactions in the network, mostly involving IL-4, while lethality is linked to a systematic reduction of complexity of these interactions and to an increase in connections between markers linked to haemolysis-induced damage.
Periodic solution of a quasilinear parabolic equation with nonlocal terms and Neumann boundary conditions
Authors: Hameed Raad Awad , Wu Boying , Sun Jiebao 
Published: February 2013

Abstract
In this article, we study the periodic solution of a quasilinear parabolic equation with nonlocal terms and Neumann boundary conditions. By using the theory of Leray-Schauder degree, we obtain the existence of a nontrivial nonnegative time periodic solution.
Book reviews
Authors: Penier Izabella , Sosnowska Monika , Skalska Tamara 
Published: February 2013

Richard Gott, Britain’s Empire: Resistance, Repression and Revolt, London & New York: Verso, 2011, pp. 568, ISBN: 9781844677382
Reghina Dascal, Ed., Episodes from the History of Undoing. The Heritage of Female Subversiveness, Newcasle upon Tyne: Cambridge Scholars Publishing, 2012, ISBN: 1-4438-3611-7
Marta Wiszniowska-Majchrzyk, Studies in 20th Century Literary/Cultural Britain, Warszawa: Wydawnictwo Uniwersytetu Kardynała Wszyńskiego, 2011, pp. 440, ISBN 978-83-7072-707-9
Man, Chicks are Just Different (Baby są jakieś inne) dir. Marek Koterski, Poland, 2011, 90 min.
The relationship between quality of self-monitoring and glycemic control in romanian children with type 1 diabetes mellitus
Authors: Timar Bogdan , Șerban Viorel , Lăcătușu Alina , Barna Laura , Fiera Florentina , Vlad Adrian 
Published: February 2013

AbstractObjectives: Optimal glycemic control is mandatory in diabetic children andadolescents for the prevention of diabetes complications, but it is difficult to beobtained due to a series of factors, including the limited availability of blood glucoseself-monitoring tests. The aim of our study was to investigate the relationshipbetween the number of daily self-monitoring tests and quality of glycemic control.Material and method: We enrolled 783 individuals previously diagnosed with Type 1Diabetes Mellitus and investigated the significance of differences in HbA1c valuesbetween groups with distinct number of blood glucose measurements at home foreach age group. Results: We found significant improvements of glycemic controlwith the increase in the number of daily tests, with some particularities among thegroups. Conclusions: Among other intrinsic and external factors, blood glucose selfmonitoringhas an important role in obtaining a good glycemic control.
Risk factors for prediabetes in overweight and obese pre-teens and adolescents
Authors: Dumbrava Larisa , Popa Amorin , Brink Stuart 
Published: February 2013

Abstract We looked for easy-to-use and predictable tools for identifying early risk ofprediabetes (PD) and preventing the natural course to diabetes in overweight andobese pre-teens and adolescents. In 89 children (9-18 years) family history, bodymass index (BMI), waist circumference (WC), acanthosis nigricans, blood pressure(BP), lipids, HbA1c, fasting glucose and oral glucose tolerance test were determined.We found 69 (77.5%) obese (BMI≥95th percentile) and 20 (22.5%) overweightchildren (BMI 85th-95th percentiles); thirty-six (41.4%) had PD; two had type 2diabetes mellitus; two had metabolic syndrome. PD was associated with obesity (RR5.1), HbA1c>5.5% (RR 2.5), acanthosis nigricans (RR=1.9), malegender (RR = 1.9), total cholesterol ≥170 mg/dL (RR=1.8), high BP (RR=1.7), urbanarea (RR = 1.6). BMI, WC, HbA1c and acanthosis nigricans are the majorpredictors for PD in this population. All blood values are both easy to measure andto accept by children, using finger prick method.
The Influence of Weight Loss on Arterial Stiffness in Obese and Overweight Subjects
Authors: Elian Viviana , Panaite Cristian , Cheta Dan , Serafinceanu Cristian 
Published: February 2013

AbstractObjectives: The Metabolic Syndrome (MetS) and obesity are among the provencauses of vascular dysfunction. The cardio-ankle vascular index (CAVI) wasdeveloped as a method to assess arterial stiffness. The aim of the study was toestablish the influence of weight loss on arterial stiffness parameters. Material and Methods: 135 subjects completed a 6 months standardized life style interventionstudy. Average initial weight was 96.63kg with a BMI of 34.34kg/m2. CAVI and theankle-brachial index (ABI) were measured and body composition was assessed.Some biochemical markers were also determined. Results: The average weightdecreased to 84.61kg, with fat mass loss of 9.6 kg. Mean CAVI decreased from7.92±1.28 to 7.21±1.08. The decrease in CAVI correlates with the total weight andfat loss rather than the speed of weight loss. Conclusions: Our results show thatweight loss can influence arterial stiffness, mainly by decreasing fat tissue mass.
Dynamics of Prostate-Specific Antigen Levels During Treatment with Testosterone Undecanoate in Patients with Type 2 Diabetes Mellitus
Authors: Dănciulescu Miulescu Rucsandra , Dănoiu Suzana , Margină Denisa , Păun Sorin , Poiană Cătălina 
Published: February 2013

AbstractObjectives.Prostate-specific antigen (PSA) is the most used and validated marker ofprostate cancer risk. The aim of this study was to assess PSA levels during treatmentwith testosteronum undecanoat in patients with type 2 diabetes (T2DM).Material and Methods. We evaluated 38 T2DM patients aged between 48 and 61 years withconfirmed hypogonadism. 1000 mg testosterone undecanoate was injectedintramuscular every 10 to 14 weeks. Total testosterone and PSA levels were assessedat baseline and after 6, 12, 24 months of treatment.Results.The average age was55.03 ± 2.40 years and 3 patients (7.89%) had a family history of prostate cancer.Treatment with testosterone undecanoate generated significant changes in serumtotal testosterone (482.29±50.78 ng/dl vs. 246.66±51.50 ng/dl, p < 0.001) but not inserum PSA levels (2.11±.0.49 ng/ml vs. 2.09±0.47 ng/ml, p - NS).Conclusion.Testosterone replacement therapy may normalize serum androgen levels but appearsto have little effect on PSA levels.
Increased susceptibility to drought‐induced mortality in Sequoia sempervirens (Cupressaceae) trees under Cenozoic atmospheric carbon dioxide starvation
Authors: Quirk Joe , McDowell Nate G. , Leake Jonathan R. , Hudson Patrick J. , Beerling David J. 
Published: February 2013

• Premise of the study: Climate‐induced forest retreat has profound ecological and biogeochemical impacts, but the physiological mechanisms underlying past tree mortality are poorly understood, limiting prediction of vegetation shifts with climate variation. Climate, drought, fire, and grazing represent agents of tree mortality during the late Cenozoic, but the interaction between drought and declining atmospheric carbon dioxide ([CO2]a) from high to near‐starvation levels ∼34 million years (Ma) ago has been overlooked. Here, this interaction frames our investigation of sapling mortality through the interdependence of hydraulic function, carbon limitation, and defense metabolism.• Methods: We recreated a changing Cenozoic [CO2]a regime by growing Sequoia sempervirens trees within climate‐controlled growth chambers at 1500, 500, or 200 ppm [CO2]a, capturing the decline toward minimum concentrations from 34 Ma. After 7 months, we imposed drought conditions and measured key physiological components linking carbon utilization, hydraulics, and defense metabolism as hypothesized interdependent mechanisms of tree mortality.• Key results: Catastrophic failure of hydraulic conductivity, carbohydrate starvation, and tree death occurred at 200 ppm, but not 500 or 1500 ppm [CO2]a. Furthermore, declining [CO2]a reduced investment in carbon‐rich foliar defense compounds that would diminish resistance to biotic attack, likely exacerbating mortality.• Conclusions: Low‐[CO2]a‐driven tree mortality under drought is consistent with Pleistocene pollen records charting repeated Californian Sequoia forest contraction during glacial periods (180–200 ppm [CO2]a) and may even have contributed to forest retreat as grasslands expanded on multiple continents under low [CO2]a over the past 10 Ma. In this way, geologic intervals of low [CO2]a coupled with drought could impose a demographic bottleneck in tree recruitment, driving vegetation shifts through forest mortality.
Une division internationale du travail diplomatique
Authors: Pouponneau Florent 
Published: February 2013

Résumé Cet article analyse la politique étrangère française articulée entre 2002 et 2006 autour du problème du nucléaire iranien. Pour les dirigeants français, cette action est l’occasion de donner à voir leur capacité de « compter » dans la régulation des affaires internationales. Cependant, la démonstration, attentive à l’évolution des conduites à l’égard des États-Unis, pointe l’apprentissage pratique par les acteurs des limites de leur espace de jeu. L’hypothèse d’une différenciation des tâches dans l’espace international des relations diplomatiques et politiques permet d’expliquer ce décalage entre les intentions des acteurs et les résultats auxquels ils parviennent. Elle permet aussi de fournir un moyen de cerner empiriquement les effets de contrainte propres au système international.
Synthesis and Cytotoxic Activity of Ursolic Acid Derivatives
Authors: Thien Dao Duc , Thanh Tam Nguyen , Thien Dinh Gia , Hoang Anh Nguyen Thi , Van Sung Tran 
Published: February 2013

10-15
Fourteen ursolic acid derivatives, among them four novel compounds, were synthesized by modification either at the C-3, C-28 or both positions. The cytotoxic activity of the obtained derivatives was evaluated against the four human cancer cell lines KB (human mouth epidermal carcinoma), HepG2 (human hepatocellular carcinoma), MCF7 (human breast carcinoma) and Lu (human lung carcinoma). As the result, compounds 7and 8were from two to three times more active than ursolic acid on all four tested cell lines. This is the first report on cytotoxic effects of the synthetized ursolic acid derivatives 4, 8, and .
Création et créativité dans la construction identitaire d’enseignantes de la danse en milieu scolaire au Québec
Authors: Duval Hélène 
Published: February 2013

La formation initiale du futur enseignant de la danse en milieu scolaire (EDMS) l’oriente vers la construction d’une identité d’enseignant-créateur. Une étude doctorale menée sur le thème de la construction identitaire d’EDMS, au regard des tensions que ces enseignants éprouvent et des stratégies identitaires qu’ils peuvent déployer pour les apaiser, identifie six sphères de négociation identitaire. L’analyse des propos des 18 participantes à l’étude établit que la tension identitaire artiste/enseignant se manifeste dans deux de ces sphères : Devenir EDMS et Agir en tant qu’EDMS. Elle est à l’origine de deux stratégies identitaires mobilisées par les participantes pour apaiser la tension : 1) La conciliation des postures artistique et pédagogique qui permet à la sensibilité, au sens pédagogique, à l’altruisme et à la création/créativité d’être activés dans la sphère Devenir EDMS et 2) L’alternance des rôles à jouer, tels que : Encourager les attitudes artistiques chez l’élève; Guider et observer les élèves dans la découverte du mouvement par des approches sensorielles et expressives; Cibler des apprentissages les plus signifiants en mobilisant les postures d’artiste et de pédagogue; Guider et soutenir les élèves en création; Favoriser les échanges et la réflexion par le questionnement de l’élève; Être un passeur culturel; Éduquer par la danse. Ces rôles sont mobilisés dans la sphère Agir en tant qu’EDMS.
L’expérience de création en théâtre pour adolescents en Ontario français : paroles et gestes
Authors: Thibault Laurence Valérie 
Published: February 2013

Le présent texte offre une perspective multiple de l’expérience du processus de création. Il examine les liens que des artistes identifient entre leur expérience de création et l’éducation artistique et culturelle des spectateurs adolescents en Ontario français. Les résultats présentés sont issus d’une recherche doctorale plus large, de type ethnographique, menée au sein de deux compagnies théâtrales à Ottawa pendant les périodes de création de deux spectacles. Une analyse interprétative des paroles et des gestes des artistes fait émerger trois rôles que ces derniers pensent jouer dans l’éducation des adolescents : l’artiste conteur, l’artiste formateuret l’artiste passeur. Cette recherche qualitative permet de comprendre comment les artistes travaillent et révèle l’ampleur de leurs initiatives et de leurs besoins liés à la création pour adolescents, notamment en contexte scolaire.
Des pratiques inspirantes pour intégrer la dimension culturelle à l’école
Authors: Raymond Caroline , Turcotte Nicole 
Published: February 2013

Dans la perspective d’exploiter la créativité dans différents contextes scolaires et dans l’apprentissage des disciplines, cet article a pour but de susciter la réflexion à l’égard de pratiques inspirantes en matière d’intégration de la dimension culturelle à l’école québécoise, tout en prenant appui sur les faits marquants qui ont permis au système éducatif québécois d’entrer dans la modernité depuis la parution du rapport Parent au début des années 1960.
Il est proposé d’expliciter les rouages du processus d’élaboration du matériel conçu à l’intention des enseignants dans le cadre du Mois de la culture à l’école. Ce matériel vise à soutenir concrètement la mise en oeuvre de pratiques représentatives d’une approche culturelle à l’enseignement que certains chercheurs en éducation ont contribué à définir et à documenter (Chené et Saint-Jacques, 2005; Falardeau et Simard, 2007). Illustrées sous forme de pistes d’activités et de vidéos accessibles dans Internet, ces pratiques constituent des exemples pouvant être réinvestis dans la formation initiale à l’enseignement. Elles contribuent aussi au développement des compétences professionnelles de l’enseignement (MEQ, 2001b), particulièrement celle qui relève de l’agir du passeur culturel. L’exploitation de ce matériel est une avenue créative pour apprivoiser les disciplines scolaires et leur apport culturel dans la formation des jeunes.
The Detection and Mapping of Saxon Sunken‐featured Buildings at Caistor St Edmund, Norfolk
Authors: Bescoby David J. , bowden William 
Published: February 2013

ABSTRACTStrong archaeological evidence exists for the presence of Anglo‐Saxon settlement at the former Roman civitas capital Venta Icenorum, including two cemeteries of early Saxon date. A large‐scale magnetic survey west of the former walled town has revealed a complex palimpsest of surviving subsurface features, several of which were cautiously interpreted as the remains of Anglo‐Saxon sunken‐featured buildings (SFBs). Targeted earth resistance measurements enhanced the interpretation in terms of likely subsurface morphology. One of these anomalies was subsequently subject to archaeological excavation, revealing the surviving remains of an SFB of middle Saxon date. The magnetic susceptibility of deposits sampled during excavation was also evaluated and a simple forward model constructed to compare a theoretical magnetic response of the structure to that observed in the field. A reasonable correlation was observed, allowing the quantitative characterization of similar magnetic anomalies revealed in the survey data. Copyright © 2013 John Wiley & Sons, Ltd.
Software sensor design considering oscillating conditions as present in industrial scale fed‐batch cultivations
Authors: Lyubenova V. , Junne S. , Ignatova M. , Neubauer P. 
Published: February 2013

AbstractInvestigations of inhomogeneous dynamics in industrial‐scale bioreactors can be realized in laboratory simulators. Such studies will be improved by on line observation of the growth of microorganisms and their product synthesis at oscillating substrate availability which represents the conditions in industrial‐scale fed‐batch cultivations. A method for the kinetic monitoring of such processes, supported by on line measurements accessible in industrial practice, is proposed. It consists of a software sensor (SS) system composed of a cascade structure. Process kinetics are simulated in models with a structure including time‐varying yield coefficients. SSs for measured variable kinetics have classical structures. The SS design of unmeasured variables is realized after a linear transformation using a logarithmic function. For these software sensors, a tuning procedure is proposed, at which an arbitrary choice of one tuning parameter value that guarantees stability of the monitoring system allows the calculation of the optimal values of six parameters. The effectiveness of the proposed monitoring approach is demonstrated with experimental data from a glucose‐limited fed‐batch process of Bacillus subtilis in a laboratory two‐compartment scale down reactor which tries to mimic the conditions present in industrial scale nutrient‐limited fed‐batch cultivations. Biotechnol. Bioeng. 2013; 110: 1945–1955. © 2013 Wiley Periodicals, Inc.
The Impact of Media Reporting of High‐Profile Cases on Child Protection Medical Assessments
Authors: Ray Samiran , Conn Kelly , Liebeschuetz Susan , Costoli Verina , Tan Meng 
Published: February 2013

Key Practitioner Messages

High profile media cases can alter the referral patterns for child protection medical assessment.
Although the increase in the total number of referrals may not be surprising, the increase in the proportion of children with signs suggestive of non‐accidental injury is worrying.
Ideally, evidenced based guidelines for the referral of children for child protection medical assessments should be formulated. Failing this, a strong inter‐disciplinary working relationship may improve consistency in referral patterns.
Prolonged high‐pressure is required for optimal stent deployment as assessed by optical coherence tomography
Authors: Cook Jeffrey R. , Mhatre Ajay , Wang Fen Wei , Uretsky Barry F. 
Published: February 2013

AimsOptimizing stent deployment is important for both acute‐ and long‐term outcomes. High‐pressure balloon inflation is the standard for coronary stent implantation. However, there is no standardized inflation protocol. We hypothesized that prolonged high‐pressure balloon inflation until stabilization of inflation pressure is superior to a rapid inflation/deflation sequence for both stent expansion and strut apposition.Methods and ResultsA high‐pressure rapid inflation/deflation sequence was deployed followed by angiography to assure no residual stenosis. Optical coherence tomography (OCT) was then performed followed by prolonged inflation until balloon pressure was stabilized for 30 sec using the same balloon at the same pressure as the rapid sequence. A second OCT run was then done. Thirteen thousand nine hundred thirteen stent struts were evaluated by OCT in 12 patients undergoing successful stenting. Stent expansion improved with prolonged (206 ± 115 sec) vs. rapid (28 ± 17 sec) inflation for both minimal stent diameter (3.0 ± 0.5 vs. 2.75 ± 0.44 mm, P < 0.0001) and area (7.83 ± 2.45 vs. 6.63 ± 1.85 mm2, P = 0.0003). The number of malapposed struts decreased (45 ± 41 vs. 88 ± 75, P = 0.005) as did the maximal malapposed strut distance (0.31 ± 0.2 vs. 0.43 ± 0.2 mm, P = 0.0001). Factors related to strut malapposition after rapid inflation included localized asymmetry in 67%, stent underexpansion in 75%, and stent undersizing in 67%.ConclusionsThese data demonstrate that prolonged inflation is superior to a rapid inflation/deflation technique for both stent expansion and strut apposition. We recommend for routine stent deployment a prolonged inflation protocol as described above to optimize stent deployment. © 2012 Wiley Periodicals, Inc.
Experimental and Theoretical Evidence of the Existence of Gold(I)⋅⋅⋅Mercury(II) Interactions in Solution through Fluorescence‐Quenching Measurements
Authors: Lasanta Tania , López‐de‐Luzuriaga José M. , Monge Miguel , Olmos M. Elena , Pascual David 
Published: February 2013

AbstractHeteronuclear complexes {[Hg(R)2][Au(R′)(PMe3)]2}n (R=R′=C6Cl2F3 (3); R=R′=C6F5 (4); R=C6Cl2F3, R′=C6F5 (5); R=C6F5, R′=C6Cl2F3 (6)) were prepared by the treatment of the corresponding organomercury compounds, [Hg(C6X5)2], with two equivalents of [Au(C6X5)(PMe3)]. Their crystal structures, as determined by using X‐ray diffraction methods, display Au⋅⋅⋅Hg interactions. Although only compound 4 and 5 show luminescence in the solid state, all of these compounds quench the fluorescence of naphthalene in solution. Solution studies of these derivatives suggest a cooperative effect of the gold(I) center in switching on the quenching capabilities of the [Hg(C6X5)2] synthon with naphthalene. Theoretical studies confirmed the quenching ability of the organomercury species in the presence of gold.
Current Status of Textile Industry Wastewater Management and Research Progress in Malaysia: A Review
Authors: Pang Yean L. , Abdullah Ahmad Z. 
Published: February 2013

AbstractTextile industry is one of the fastest growing industries and significantly contributes to the economic growth in Malaysia. However, this industry also has high water consumption and subsequently produces high discharge rate of wastewater with high load of contaminants. The release of dyes into the environment during textile fiber dyeing and finishing processes is a main source of water pollution. Individual wastewater treatment through physical, biological, or chemical method is often very costly and results in large amount of sludge. Thus, there is a need to look for alternative treatment processes that covers from pre to post wastewater treatment stage. This paper reviews the current scenario with respect to textile industry effluent in Malaysia and technologies available for the treatment of the effluent. Prospects, challenges, and recommendations for future direction as well as on‐going research works dedicated to the treatment of textile wastewater are also reviewed in detail.