bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sexual Habits and Clinico‐Etiological Profile of Sexually Transmitted Diseases in Nepal
Authors: Garg Vijay Kumar , Agarwalla Arun , Agrawal Sudha , Deb Manorama , Khanal Basudha 
Published: July 2014

AbstractA total of 100 patients giving histories suggestive of sexually transmitted disease (STDs) and attending the dermatology OPD at BPKIHS (B.P. Koirala Institute of Health Sciences) in Nepal over a period of one year from 1st July 1999 to 30th June 2000 were included in this study. Out of 10,400 new dermatology cases, a total of 100 cases (0.96%) of STDs were seen. Of these 73 were males, and the majority (53%) were in the age group of 21–30 years. Most of the patients were from Sunsari district (54%). The most common profession (21%) was businessman followed by housewife (19%). The most common age for first sexual contact was 16 to 19 years (45%). Eleven percent had their first sexual contact at the age of 15 or below 15 years. Premarital sexual exposure was recorded in 17% of the unmarried males. There were only 3 homosexuals and 1 bisexual patient. Multiple contacts were recorded in 55% of the patients. The most common source of contact was a commercial sex worker in 34.15%. Condoms were always used by only 7%. The various types of sexually trasmitted diseases (STDs) were syphilis (31%) followed by condylomata acuminata (16%), herpes genitalis (15%), gonorrhoea (9%), and mixed infections (12%). Despite their varied sexual behavior, none of the patients were HIV positive; however, it is always advisable to screen all STD patients for HIV antibody.
A Case of Kaposi's Sarcoma Associated with Pemphigoid Nodularis
Authors: Gao Xing‐Hua , Lin Junping , Yang Ciying , Ma Lei , Wang Guanqing , Wang Yakun , Chen Hong‐Duo 
Published: July 2014

AbstractPemphigoid nodularis is a rare variant of bullous pemphigoid. Bullous pemphigoid complicated by internal malignancy has been well documented. There have been only a few reported cases of bullous pemphigoid associated with Kaposi's sarcoma. We described a case of pemphigoid nodularis who later developed Kaposi's sarcoma that might be related to immunosupressive therapy, a situation that has not been reported previously.
A Possible Mechanism of Mast Cell Proliferation in Mastocytosis
Authors: Kambe Naotomo , Miyachi Yoshiki 
Published: July 2014

AbstractThe abnormality in mastocytosis is the excessive accumulation of mast cells in the affected tissue. The growth and differentiation of human mast cells are quite dependent on stem cell factor (SCF), the ligand for the protein products of c‐kit. Recent studies have demonstrated that all adult patients examined so far carry c‐kit point mutations, leading to SCF‐independent autophosphorylation of the receptor and autonomous cell growth. On the other hand, typical pediatric patients have been found to bear no activating Asp816Val mutation in c‐kit. Although most mastocytosis patients are children, the mechanism by which mast cells proliferate in these pediatric patients remains unclear. Recently, we reported that human mast cells obtained from adult skin could dramatically proliferate when cultured with SCF. From these experimental results, it is speculated that local excessive production of SCF results in the mast cell proliferation in pediatric patients.
Minocycline Effectively Reduces Acid Producted by Propionibacterium granulosum
Authors: Higaki Shuichi , Kitagawa Taro , Morohashi Masaaki , Yamagishi Takayoshi 
Published: July 2014

AbstractWe studied the effects of minocycline on Propionibacterium granulosum. P. granulosum lipase activity was detected from acne lesions. Production of propionic and butyric acids by P. granulosum was well suppressed by all tested media with added minocycline; the higher the concentration of minocycline in the medium, the less of these acids was produced. It appeared that the decrease in these acids due to minocycline was greater in P. granulosum than in P. acnes. Although the influence of P. granulosum on acne lesions might be feebler than that of P. acnes, we should not neglect its presence. More research is needed to elucidate the relationship between the two species in acne lesions.
Rising Incidence of Genital Herpes over Two Decades in a Sexually Transmitted Disease Clinic in North India
Authors: Kumar Bhushan , Sahoo Bijaylaxmi , Gupta Somesh , Jain Rajesh 
Published: July 2014

AbstractGenital herpes, which was considered to be a minor sexually transmitted disease (STD) in the past in developing countries, is rapidly increasing; in contrast, bacterial STDs are declining. This changing trend of various STDs prompted us to analyze our data retrospectively to see whether a similar change is occurring in this part of India as well. The records of sexually transmitted diseases (STDs) clinic attendees from January 1977 to December 2000 were analyzed. The demographic profile of patients with genital herpes was also considered for analysis. STDs were diagnosed clinically and by appropriate laboratory tests wherever applicable. VDRL test was done in all patients, and HIV antibody detection was performed from 1987 onwards. The incidences of chancroid, donovanosis, and gonorrhea were 12.2%, 6.3%, and 16.9%, respectively, from January 1977 to December 1985. The figures for the same decreased to 2.5%, 0.9%, and 2.3%, respectively, from January 1993 to December 2000. The decreasing incidence of the above bacterial STDs is statistically significant (p<0.001). However, there was an approximately two‐fold increase in the incidence of genital herpes in recent years (20.5%) in comparison to the figures from the late 70s (11.4%). Molluscum contagiosum also showed an upward trend (1% in 1977–85 vs. 9.8% in 1993–2000). Condylomata accuminata remained almost unchanged (21.4% in 1977–85 vs. 20% in 1993–2000). To conclude, a significant increase in the number of viral STDs and a decline in the bacterial diseases were observed in recent years in comparison to the figures from the late 70s. This may be due to awareness of HIV, success of control programs, syndromic management of STDs, and adoption of safer sexual practices, which prevent bacterial STDs more efficiently than viral ones.
A Case of Eruptive Collagenoma Localized on the Neck and Shoulders
Authors: Amaya Misato , Okubo Yukari , Koga Michiyuki 
Published: July 2014

AbstractA 78‐year‐old woman, who had first noticed asymptomatic eruptions on her neck and shoulders eight years earlier, presented with papules and nodules 2 to 20 mm in diameter that had a normal to white hue and were flatly elevated. These lesions were scattered and multiple, some forming confluent plaques. Histopathologically, the epidermis was slightly atrophied, and collagen fibers in the dermis were coarse and proliferated. In addition, the number of elastic fibers was slightly decreased. No complications were evident. Based on these findings, the patient was given a diagnosis of mild eruptive collagenoma, a type of connective tissue nevus according to the classification of Uitto. This case is unique in that onset was at an advanced age and that distribution was localized on the neck and shoulders.
Pyoderma Gangrenosum Associated with Paroxysmal Nocturnal Hemoglobulinuria and Monoclonal Gammopathy
Authors: Matsubara Kimiko , Isoda Ken‐ichi , Maeda Yoshitami , Mizutani Hitoshi 
Published: July 2014

AbstractPyoderma gangrenosum developed in a man with a five‐year history of paroxysmal nocturnal hemoglobinuria and monoclonal gammopathy. He had multiple walnut sized ulcers on his back and extremities, plasma IgM‐k type M‐protein and low erythrocytic CD55 expression. This is an extremely rare association. However, clonal expansion of plasma cells and chimeric expression of hematopoietic cell glycosylphosphatidylinositol (GPI)‐anchored proteins may represent somatic mutations of hematopoietic stem cells in PG as well as PNH. PNH is based on abnormalities in the GPI‐anchor formation on various hematopoietic and non‐hematopoietic cells. Since the GPI‐anchored proteins have pleiotropic functions in complement mediated cell lysis, leukocyte motility, and coagulation systems, the present case may indicate the possible involvement of a GPI‐anchored protein abnormality in the pathogenesis of PG.
Gamma Interferon Directly Inhibits the Growth of Neurofibroma Cells In vitro
Authors: Nakayama Juichiro , Terao Hiroshi 
Published: July 2014

AbstractVarious neurofibroma cell lines isolated from either dermal, plexiform, or diffuse neurofibromas were found to respond to human gamma interferon by decreasing proliferation rates in vitro. The cell number decreased to around 40–50% of controls (without gamma interferon) six days after the treatment. The cell lines showed dramatic inhibition of tritium‐labeled thymidine uptake one day after the treatment with gamma interferon. Either 100 IU/ml or 1000 IU/ml of gamma interferon resulted in the same range of inhibition. It is calculated that venous infusion of one vial of commercial recombinant gamma interferon (200 × 106 IU/ml) reaches more than 100 IU/ml in the peripheral blood, which means that it may be clinically useful. The cell lines also responded to gamma interferon by initiating expression of CD54. Immunological modulation of neurofibroma cell components by gamma interferon in vivo remains to be studied.
An Assessment of the Malignant Potential of Actinic Keratoses and Bowen's Disease: p53 and PCNA Expression Pattern Correlate with the Number of Desmosomes
Authors: Ramzi Saeef Taher , Maruno Motoyoshi , Khaskhely Noor Mohammad , Khan Mohammed Abul Kasem , Takamiyagi Atsushi , Uezato Hiroshi , Nonaka Shigeo 
Published: July 2014

AbstractActinic keratoses (AK) and Bowen's disease (BD), both intraepidermal skin tumors, have a potential progression to squamous cell carcinoma (SCC). To evaluate the malignant potential of AK and BD, the expression pattern of p53 protein and proliferating cell nuclear antigen (PCNA) were examined in five types of AK and BD by immunohistochemistry. The ultrastructural difference of epidermal cells between AK and BD lesions was investigated. In the study of p53 and PCNA expression, the atrophic and acantholytic types of AK showed lower positive rates compared to others. These two types did not demonstrate all layers expression pattern. The number of desmosomes of the epidermal cells was significantly reduced in BD, and in the bowenoid and hypertrophic types of AK compared with other types of AK. The number of hemi‐desmosomes showed greatest reduction in BD and the bowenoid type of AK. On the basis of our findings, it is hypothesized that atrophic and acantholytic types of AK may have the lowest, and the bowenoid type of AK and BD may have the highest, malignant potential.
Uremic Pruritus: A Clinical Study of Maintenance Hemodialysis Patients
Authors: Szepietowski Jacek C. , Sikora Magdalena , Kusztal Mariusz , Salomon Joanna , Magott Maria , Szepietowski Tomasz 
Published: July 2014

AbstractUremic pruritus is one of the most bothersome symptoms in patients with chronic renal failure. Its pathogenesis remains unclear. The aim of this study was to evaluate the frequency of uremic pruritus in hemodialysis patients and to correlate its presence and intensity with several clinical parameters. One hundred thirty patients on maintenance hemodialysis were included into the study. The intensity of pruritus was assessed by two methods: visual analog scale and specially adapted questionnaire scoring method. A significantly positive correlation (p<0.00001) was demonstrated between the two methods for evaluating pruritus. Uremic pruritus was found in 40.8% of patients. An additional 36.1% of patients reported pruritus to have been present in the past during the renal disease period. Itching was generalized in 19% of patients; the remaining subjects suffered from scattered pruritus (50%) or pruritus in a single location (31%). A significant positive relationship (p<0.02) was demonstrated between the total score of pruritus and duration of the hemodialysis period. Severity of pruritus and sleep disturbance caused by itching also significantly correlated (p<0.05) with the duration of hemodialysis. Patients hemodialysed on polysulphone membranes more commonly suffered from pruritus than those on hemophane (p<0.04) or cuprophane (p<0.03) dialysis membranes. A marked relationship was demonstrated between the intensity of xerosis and prevalence of pruritus. Significantly more patients with very rough skin had pruritus compared to those with rough skin (p<0.05) and those with slightly dry skin (p<0.02). Itching was more common in female patients (p<0.04), but patient age, underlying renal disease and erythropoietin intake did not correlate with the incidence or intensity of pruritus.
Elevation of IL‐6 in ATL Patient with a Pathological Fracture
Authors: Anzai Saburo , Takayasu Susumu , Fujiwara Sakuhei , Tateyama Masamichi , Taira Hirohumi , Takashita Mitsuhiro 
Published: July 2014

AbstractHypercalcemia and osteolytic bone lesion are important complications in the prognosis of patients with adult T cell leukemia/lymphoma (ATL). We report a 61‐year‐old Japanese woman who died of ATL and had multiple osteolytic lesions and pathological fractures of her extremities. Highly increased serum levels of Interleukin‐6 (IL‐6) and a parathyroid hormone‐related protein (PTHrP) together with a high level of serum calcium observed at the time of fractures suggested their contribution to the formation of the bone lesions.
Chemotherapy of Disseminated Cutaneous Classic Kaposi's Sarcoma with Vinblastine
Authors: Turk H. Mehmet , Buyukberber Suleyman , Camci Celalettin , Inaloz H. Serhat , Sari Ibrahim , Kirtak Necmettin , Uner Aytug 
Published: July 2014

AbstractClassic Kaposi's Sarcoma (KS) is a rare indolent cutaneous malign proliferative disease affecting predominantly elderly men of Mediterranean and Jewish origin. Classic KS generally does not require treatment for a prolonged time. Systemic therapy is indicated for patients with advanced disease. We present here a 78‐year‐old woman with disseminated cutaneous classic KS who was successfully treated with single agent vinblastine. Vinblastine is very effective, less toxic and less costly in the treatment of elderly patients with disseminated classic KS.
Seventeen Cases of Alopecia Areata: Combination of SADBE Topical Immunotherapy with Other Therapies
Authors: Morita Kazumasa , Nakamura Motonobu , Nagamachi Miyako , Kishi Tatsuo , Miyachi Yoshiki 
Published: July 2014

AbstractTopical immunotherapy is effective for severe alopecia areata. However, there are patients with alopecia areata refractory to topical immunotherapy alone. We tried SADBE (squaric acid dibutylester) topical immunotherapy combined with topical dry ice cryotherapy, carpronium chloride (a parasympathetic nerve stimulant) and/or oral cepharanthin (a biscoclaur alkaloid) in alopecia areata refractory to topical SADBE. Seventeen patients with alopecia areata (3 multiple, 3 ophiasis, 5 totalis and 6 universalis) were treated with SADBE in our department in 1999 to 2001. In 3 cases (2 multiple and 1 universalis) out of the 17 cases, cosmetically acceptable regrowth of hair was observed in several months with topical SADBE alone. In the other 14 cases, the SADBE therapy alone for several months (mean: 6.9 months) resulted in no or poor regrowth of hair. However, with subsequent combination therapy of topical SADBE for several months (mean: 7.6 months), satisfactory regrowth of hair was observed in 6 of the 14 cases. Our cases indicate that combination therapy of topical SADBE with other therapies can be a choice for alopecia areata which is refractory to topical SADBE therapy alone.
Depression Circumstantially Related to the Administration of Finasteride for Androgenetic Alopecia
Authors: Altomare Gianfranco , Capella Giovanni Luigi 
Published: July 2014

AbstractIn this paper we report 19 patients (14 males, 5 females; mean age 28.16 years ± 7.68 SD) out of a series of 23 (17 males, 5 females) who developed a mood disturbance (moderate to severe depression) during treatment with finasteride, 1 mg/day orally, for androgenetic alopecia (Hamilton subtypes III–V; Ludwig subtypes I–II). Depression, which significatively impaired sociofamilial relations, sleep and eating behaviour, was associated to marked anxiety in some cases, developed after 9–19 weeks of treatment with finasteride, and promptly resolved after suspension of the drug. Two patients accepted reintroduction of the drug, and depression relapsed within 2 weeks. Depression as an adverse effect of finasteride has been reported only once. Further studies are needed to confirm our circumstantial observations, which are based on a retrospective series of patients.
A Monoclonal Antibody Established from the Immunization of Basal Cell Carcinoma (BCC) Tissues Reacts to the Intercellular Space of BCC and Hair Follicles
Authors: Kore‐eda Satoshi , Matsuyoshi Norihisa , Ueda Masamichi , Horiguchi Yuji , Miyachi Yoshiki , Imamura Sadao 
Published: July 2014

AbstractTo detail the histogenetic relationship between basal cell carcinoma (BCC) and hair follicles, a monoclonal antibody, coded as MMKB‐1 and established from immunization of mice by human basal cell carcinoma (BCC) tissues, was immunohistochemically studied in tissues of BCC and squamous cell carcinoma (SCC) of the skin, as well as in normal human skin tissues. On 1M‐NaCl‐split normal human skin tissues, it reacted against both the epidermal and the dermal sides of the basement membrane zone (BMZ). This monoclonal antibody reacted to the BMZ and intercellular space (ICS) of the solid, superficial, and fibrosing types of BCC cell nests, but, in SCC tumor cell nests, it reacted exclusively to the BMZ. Immunoelectron microscopic studies revealed that the corresponding antigen of the monoclonal antibody was distributed in the hemidesmosomes and the anchoring fibrils along the BMZ of the normal human skin and the desmosomes of the BCC cell nest. The monoclonal antibody also reacted to the ICS of the lower outer root sheath and hair matrix. We discussed the histogenesis of BCC and hair follicles, referring to the results of the staining patterns of MMKB‐1 monoclonal antibody and to other studies suggesting a histogenetic relationship between BCC and hair follicles.
Evaluation of Cosmetic Tattooing in Localised Stable Vitiligo
Authors: Mahajan Bharat Bhushan , Garg Geeta , Gupta Rajesh Rani 
Published: July 2014

AbstractThirty patients with localised stable vitiligo were selected from the Out Patient Department for cosmetic tattooing. Of them, 19 cases (63.3%) had skin patches, 9 cases (30%) had mucosal patches, and 2 cases (6.7%) had both skin and mucosal involvement. After complete clinical evaluation, cosmetic tattooing was performed on these patients, and they were followed up for 6 months. As results, 23 cases (76.7%) had excellent color matching, 2 cases (6.7%) had good color matching, and 5 cases (16.6%) had pigment shedding. Excellent results were seen in all mucosal patches. Dark complexion cases showed better results than fair complexion ones.
Aneurysmal Fibrous Histiocytoma Showing Transition from Factor XIIIa‐Positive to ‐Negative
Authors: Inui Shigeki , Itami Satoshi , Yoshikawa Kunihiko 
Published: July 2014

AbstractA 39‐year‐old woman visited us because of a subcutaneous induration on her forehead of 7 months' duration. The tumor was tender, firm, and colored blue‐black. Microscopically, the tumor was composed of fibroblastic and histiocytic cells showing no atypicality. In some part intra‐ or extracellular haemosiderin was diffusely seen. There were some blood‐filled spaces of varying size without endothelial lining. From these findings, this case was diagnosed as aneurysmal fibrous histiocytoma (AFH), a variant form of dermatofibroma. Immunohistochemical analysis showed that factor XIIIa‐positive histiocytic cells were distributed in the area without haemosiderin, but such cells were absent in the area with its deposition. Furthermore, the cells near the blood‐filled space showed transition from factor XIIIa‐positive to ‐negative, suggesting that the stromal instability induced by the attenuation of factor XIII may lead the formation of the blood‐filled spaces in AFH.
Childhood Bullous Pemphigoid Following Hepatitis B Immunization
Authors: Erbagci Zülal 
Published: July 2014

AbstractBullous pemphigoid (BP) is an acquired autoimmune bullous disorder which predominantly affects the elderly. It is very rare in children. There are approximately 50 reported cases of childhood BP. Although the cause of childhood BP is unknown, drug intake and vaccination have been incriminated in some cases. A total of 13 patients with BP (10 adults and 3 infants) have been described to be related to various vaccines and tetanus toxoid booster. However, no case related to hepatitis B vaccination has previously been reported. Our case of childhood BP developed one week after hepatitis B immunization in a Turkish caucasian child. This case suggests that the hepatitis B surface antigen can function as the triggering factor for BP by inducing a nonspecific immune reactivation which unmasks subclinical BP or by stimulating a specific antibody production that may cross–react with BP antigens.
Carney Complex: Report of a Japanese Case Associated with Cutaneous Superficial Angiomyxomas, Labial Lentigines, and a Pituitary Adenoma
Authors: Takahashi Hiroyuki , Hida Tokimasa 
Published: July 2014

AbstractWe report the case of a 12‐year‐old female patient who manifested multiple cutaneous angiomyxomas and labial pigmented lesions. Although the familial history was not confirmed in the present case, autosomal dominant inheritance has been reported to be involved in the pathogenesis of this condition. In addition to the cutaneous complications, magnetic resonance (MR) images revealed the presence of a pituitary adenoma, which provoked an elevation of serum growth hormone (GH) level. On the other hand, no significant symptoms such as cardiac myxoma, myxoid fibroadenoma of the breast, or adrenocortical complaints suggesting Cushing syndrome, were detected. In the Japanese literature, only a few cases of this disorder have been described in the form of brief reports. There have been only a few similar cases described in the dermatological field, except for one report diagnosed as Carney complex in 1990. Therefore, the present case seems to be the first Japanese case of typical Carney complex manifesting major clinical complications, including angiomyxomas, lentigines, and a pituitary adenoma, which induced endocrine overactivity.
Cutaneous Nocardiosis Developing around Gravel Inserted during a Traffic Injury
Authors: Gyotoku Takashi , Kayashima Ken‐ichi , Nishimoto Katsutaro , Ono Tomomichi 
Published: July 2014

AbstractA 65‐year‐old Japanese woman with nocardial mycetoma which developed five years after a compound bone fracture of the left foot due to a traffic accident was reported. During this accident, two small pieces of gravel had entered her foot. Nocardia asteroides, which had been attached to the gravel, was probably inserted 5 years previously during the trauma. The lesion did not respond to oral minocycline and trimethoprim‐sulfamethoxazole and was finally removed surgically; she has been free from recurrences for one year, of follow‐up.
Efficacy of Oral Minocycline and Hyperthermic Treatment in a Case of Atypical Mycobacterial Skin Infection by Mycobacterium marinum
Authors: Hisamichi Katsuya , Hiruma Masataro , Yamazaki Masashi , Matsushita Akiko , Ogawa Hideoki 
Published: July 2014

AbstractWe report a case of atypical mycobacterial dermal infection caused by M. marinum, which was effectively treated with oral administration of minocycline and local hyperthermic treatment using chemical pocket warmers. A daily oral dose of 200 mg of minocycline was given, and local hyperthermic treatment was applied every evening for 5–6 hours with a disposable chemical pocket warmer. After 2.5 months of therapy, the lesion healed completely with scar formation. At 24 months after the completion of treatments, there is no sign of recurrence.