bluuebunny/crossref_metadata_2025_split huggingface dataset:
The importance of mother-child interction on smart device usage and behavaior outcomes among toddlers: a longitudinal study
Authors: Chakranon Pairote , Huang Jian-Pei , Au Heng-Kien , Lin Chen-Li , Chen Yi-Yung , Mao Shih-Peng , Lin Wen-Yi , Zou Ming-Lun , Estinfort Wanda , Chen Yi-Hua 
Published: July 2024

Abstract

Background
In recent years, smart devices have become an integral part of daily life. However, longitudinal studies, particularly those regarding the relationship between toddlers’ smart device usage and behavioral outcomes, are limited. Understanding the impact of parent–child interactions on this relationship is crucial for enhancing toddlers’ developmental outcomes. Accordingly, this study examined the influence of early screen time and media content exposure on toddlers’ behaviors, as well as the positive effects of mother–child interactions on this influence.
Methods
We used relevant data related to 277 children born between November 2016 and July 2020 and who were part of an ongoing prospective follow-up study conducted across five hospitals in Taipei City, Taiwan. We analyzed (1) data from maternal reports regarding children’s behavior by using the Child Behavior Checklist (for ages 11/2–5 years), (2) assessments of mother–child interactions by using the Brigance Parent–Child Interactions Scale, and (3) self-reported parental data covering the first 3 postpartum years. Statistical analyses involved group-based trajectory modeling and multiple linear regression.
Results
A considerable increase in screen time between the ages of 1 and 3 years was associated with less favorable behavioral outcomes at age 3. These outcomes included somatic complaints [adjusted beta coefficient (aβ) = 2.17, 95% confidence interval (CI) = 0.39–3.95, p-value = 0.01], withdrawal (aβ = 2.42, 95% CI = 0.15–4.69, p-value = 0.04), and aggressive behavior (aβ = 6.53, 95% CI = 0.25–12.81, p-value = 0.04). This association was particularly evident among children with lower levels of mother–child interaction. Nevertheless, positive mother–child interactions mitigated most of the adverse effects. Additionally, increased exposure to games and cartoons was associated with poorer behavioral outcomes in all children except for those experiencing positive mother–child interactions.
Conclusion
Early mother–child interactions play a crucial role in mitigating the risk of behavioral problems in toddlers who spend prolonged periods looking at screens and who are frequently exposed to game and cartoon content.
Examining the use of complementary and alternative medicine among older persons in Ebonyi State, southeast Nigeria: a qualitative study
Authors: Agu Chibuike Innocent , Iloabachie Ugenyi Victoria , Oka Onyinyechukwu Uzoamaka , Eze Irene Ifeyinwa , Okoro Lenz Nwachinemere , Ossai Edmund Ndudi 
Published: July 2024

Abstract

Background: Although complementary and alternative medicine is popular among older people, there is limited understanding of its use within this subpopulation. This study aimed to explore the perceptions of older people in the communities of Ebonyi State regarding the use of complementary and alternative medicine.
Methods:Qualitative data were collected through the use of focus group discussions (FGDs), from four communities two each from urban and rural areas of Ebonyi state, Nigeria. A total of 12 FGDs involving 96 participants were conducted. A thematic analysis of data was performed with the aid of NVivo software.
Result: Almost all participants expressed a belief in the inherent benefits of complementary and alternative medicine, which were categorized into medical and non-medical reasons. Febrile illnesses, including malaria, typhoid fever, and hepatitis; respiratory; haematological; and dermatological conditions were reported as common health conditions for which participants used CAM. Additionally, participants mentioned using CAM for chronic conditions, such as diabetes mellitus, hypertension, and arthritis, as well as for health promotion and wellbeing. Preferences for CAM were influenced by beliefs in its effectiveness, perceived lower cost compared to conventional treatments, delays in hospital diagnoses and treatments, and belief in the spiritual origins of diseases. Safety concerns regarding CAM use included a lack of information on dosing, directions for safe use, and potential side effects.
Conclusion:The study findings indicate a strong belief among participants in the benefits of complementary and alternative medicine which they believe offer both medical and non-medical advantages. However, despite these perceived benefits, safety concerns were also raised by the participants. Efforts to promote education and awareness about CAM, improve access to reliable information, and ensure the safe and effective use of CAM therapies are crucial for supporting the health and well-being of older persons who choose to incorporate CAM into their healthcare practices.
Adipose mesenchymal stem cells derived exosomes ameliorates KOA cartilage damage and inflammation by activation of PINK1-mediated mitochondrial autophagy
Authors: Kang Junfeng , Jie Lishi , Fu Houyu , Zhang Lu , Lu Guozhen , Yu Likai , Tian Di , Liao Taiyang , Yin Songjiang , Xin Runlin , Wang peimin 
Published: July 2024

Abstract

Knee osteoarthritis (KOA) is characterized by degenerative destruction of knee cartilage. Adipose tissue-derived mesenchymal stem cells (MSCs) have been widely used in the clinic to treat joint diseases, and the exosomes secreted by adipose tissue-derived MSCs (ADSC-Exos) are more stable and easier to store than stem cell therapy alone. The aim of this study was to investigate whether ADSC-Exos could reduce KOA chondrocyte damage and inflammation by activating mitochondrial autophagy. In vitro, we induced a KOA chondrocyte model with lipopolysaccharide (LPS), and after treatment with ADSC-Exos, we assessed chondrocyte damage and inflammation by using HE, Senna O solid green, and Alcian blue staining and IL-1β immunofluorescence analysis. We also labeled chondrocytes and assessed their intracellular levels of reactive oxygen species (ROS) using the DCFH-DA probe, assessed the mitochondrial membrane potential of chondrocytes using a mitochondrial membrane potential detection kit (JC-1). In vivo, we constructed a KOA rat model by anterior cruciate ligament tenotomy (ACLT) surgery, treated the knee joint with a local injection of ADSC-Exos, reconstructed the knee joint in three dimensions using micro-CT, and evaluated the pathological changes in cartilage tissues by using HE, Senna O solid green and alcian blue staining. The in vivo and in vitro results showed that ADSC-Exos upregulated the expression of PINK1/Parkin pathway components, promoted mitochondrial autophagy in chondrocytes, increased the mitochondrial membrane potential, protected mitochondrial function in chondrocytes, and ameliorated the degradation of the cartilage matrix and inflammation during KOA.
A 24 hours changes and reactivity in heart-rate variability during the Iowa gambling task may predict Internet addiction: Weak top-down control among young students
Authors: Ono Yasuki , Soma Daiki , Hirosawa Tetsu , Sagawa Kouichi , Ogura Mototsugu , Kikuchi Mitsuru 
Published: July 2024

Abstract

This study evaluated the influence of excessive Internet use on heart rate variability(HRV) using a 24 hour electrocardiogram (ECG) and examined acute changes during the Iowa gambling task (IGT) and a computer game. We recruited 35 men, and divided them into high-risk Internet addiction (HIA) and low-risk Internet addiction (LIA) groups based on their Internet addiction test scores. The ECG was recorded continuously for 24 hour using a wearable sensor and during the IGT and each participant’s preferred game using a standard ECG system. Multiple psychometric tests were conducted. The HIA group exhibited more clinically significant depressive symptoms, and higher self-reported scores for anxiety, and autistic tendencies than the LIA group. Differences were observed in the 24 hour high-frequency (HF) band power and standard deviation of the normal-to-normal (SDNN) inter-beat interval between the two groups. The tendency toward Internet addiction differed by age; thus the participants were divided into two groups according to age to examine the differences between them. In the IGT, younger participants exhibited a reduced HF response. Young people’s impulse control, and the autonomic nervous system are maturing, and autonomic responses to tasks need to be assessed in an age-appropriate manner.
Aquifer Risk Management Using Swot Analysis: Strategies for Groundwater Conservation and Demand Management.
Authors: Retshedisitswe Thuto Letuka , Saheed Adeyinko Oke 
Published: July 2024

Abstract

The sustainability of aquifers, vital sources of freshwater, faces increasing threats due to over-extraction and contamination. This paper proposes a comprehensive approach for aquifer risk management utilizing SWOT (Strengths, Weaknesses, Opportunities, Threats) analysis in the B60D sub-catchment of the Olifants Water Management Area. By integrating this strategic framework, the study aims to delineate effective strategies for groundwater conservation and demand management. Drawing on interdisciplinary perspectives, the research examines the internal and external factors influencing aquifer sustainability, including hydrogeological characteristics, socio-economic dynamics, and regulatory frameworks. Through SWOT analysis, inherent strengths such as natural recharge mechanisms and weaknesses such as vulnerability to pollution are identified alongside opportunities like technological advancements and threats such as climate change impacts. Based on these insights, a suite of adaptive strategies is formulated, encompassing sustainable abstraction practices, land use planning, community engagement, and policy interventions. Additionally, the paper highlights the importance of stakeholder collaboration and adaptive management approaches in implementing these strategies. Case studies and empirical data are incorporated to illustrate the application and effectiveness of the proposed framework in diverse aquifer contexts. Ultimately, this research contributes to advancing aquifer sustainability by offering a structured methodology for proactive risk assessment and strategic decision-making, thereby fostering resilience in groundwater management practices.
Bioelectrical impedance vector analysis and phase angle in response to resistance training volume reduction in older women
Authors: Santos Leandro dos , Antunes Melissa , Gobbo Luís , Silva Analiza , Cunha Paolo , Kassiano Witalo , Cyrino Letícia , Nabuco Hellen , Rodrigues Ricardo , Sardinha Luis , Cyrino Edilson 
Published: July 2024

Abstract

BACKGROUND Bioelectrical impedance vector analysis (BIVA) and phase angle (PhA) are important for monitoring hydration, muscle function, and quality of life in older adults. Resistance training (RT) can counteract aging's adverse effects on cellular integrity and function.OBJECTIVE This study compared the effects of RT volume reduction on BIVA and PhA in physically independent older women. Sixty-seven participants (> 60 years) underwent a 20-week standardized whole-body RT program (eight exercises, three sets each, three non-consecutive days per week). They were then randomly assigned to one of three eight-week training conditions: reduced volume to one set (RV1, n = 22), two sets (RV2, n = 24), or maintained volume (MV, n = 21). Bioimpedance spectroscopy measured total body water (TBW), intracellular (ICW), and extracellular (ECW) water, BIVA, and PhA based on resistance (R), impedance (Z), reactance (Xc), and height (H). All groups showed significant increases in TBW, ICW, and ECW during the volume reduction phase (P < 0.05).RESULTS R, R/H, Z, and Z/H decreased across all groups, with significant changes from the pre-conditioning phase in the RV1 and RV2 groups (P < 0.05). Xc and Xc/H increased during the pre-conditioning phase across all groups and returned to baseline during the volume reduction phase (P < 0.05). PhA increased during the pre-conditioning and was maintained during the volume reduction phase (RV1 = + 0.33°, RV2 = + 0.50°, MV = + 0.47°; P < 0.05).CONCLUSION These results suggest that reducing RT volume by up to one-third can still improve PhA, BIVA, and hydration status in older women.
View of healthcare professionals on ultra-rapid genome sequencing and its implementation in clinical routine for critically ill children
Authors: Caillot Claire , Javouhey Etienne , HAYS Stephane , GOUY Evan , Monin Pauline , Lesca Gaetan , Sanlaville Damien , Chatron Nicolas 
Published: July 2024

Abstract

The clinical utility of ultra-rapid genome sequencing (urGS) in neonatal and paediatric intensive care situations has been demonstrated, and barriers to its implementation in clinical practice studied. We carried out the first study to identify the expectations of French healthcare professionals of the field. A 38 questions form was distributed via medical professional learned societies to these healthcare professionals. A hundred and sixteen responses were received: 35% from clinical geneticists, 19% from laboratory geneticists, and 32% from paediatric or neonatal intensivists. 97% respondents agreed that healthcare professionals should receive specific training before a first prescription. 94% of professionals considered urGS useful, and 97% that the result would likely modify a decision to withdraw life-sustaining treatment. A multidisciplinary validation of the urGS request was necessary for 87% of respondents, and multidisciplinary discussion of the result for 84%. Joint reporting of results by a clinical geneticist and NICU/PICU doctor was considered ideal for 91% of participants. 78% were against additional findings being reported at the same time as the result. For 99% of respondents, psychological assistance was crucial after the result. Based on our results, we propose a workflow to facilitate implementation in a maximum of centers.
Thermal Management of Power Modules Based on the Hybrid Cooling System: Phase Change Material with Coolant Fluid
Authors: elmi ehsan abdi , Lavasani arash Mirabdolah , Dinarvand Saeed , Nimafar Mohammad 
Published: July 2024

Abstract

Keeping the operating temperature in the allowable range of the power module, under a very high heat flux, is of particular importance in the performance of the systems and their reliability. In this investigation, as a new approach, a new hybrid thermal heat sink consisting of phase change material with different arrangement and mass flow rates has been used for cooling an Insulatedgate bipolar transistor. As an innovation, to reduce the operating temperature of the power module at a heat flux of 100 W/cm2, the paraffin and Metal-based PCM have been applied in the water cooling chamber and simulated simultaneously. The finite volume method and piezo algorithm was used to solve the governing equations. Then, the effect of the flow rate and arrangement of PCMs on temperature variations of the power module has been examined in terms of time. The melting process of the PCM was numerically simulated by the enthalpy-porosity method in threedimensional computational domain. The results revealed that using the metal-based PCM compared to paraffin due to its high thermal conductivity increased the heat transfer rate. As a result, the operating temperature of the power module decreased. Also, metal-based PCM in 4 different arrangements (A,B,C,D) performs better than the conventional cooling system. Finally, it reduced the operating temperature of the power module. Based on the results obtained at flow rates of 0.0025, 0.00375, and 0.005 kg/s, arrangement Case D showed the best performance by reducing 3 °C compared to the pure working fluid in the power module.
Ethanol Leaf Extract of Buchholzia coriacea Ameliorates Biochemical Dysregulations Due to Rheumatoid Arthritis in Wistar Albino Rats
Authors: Alum Esther Ugo , Krishnamoorthy Rajapandiyan , Gatasheh Mansour K. , Subbarayan Shanthi , Vijayalakshmi Periyasamy , Awoke Joshua N. 
Published: July 2024

Abstract

Background
Rheumatoid arthritis (RA) is a disease that involves many body organs. In this study, we examined the anti-rheumatoid arthritis effect of ethanol leaf extract of Buchholzia coriacea (ELEBC).
Methods
Firstly, the chemical compositions of ELEBC were investigated. The in vivo study was further done using 90 female rats weighing 121–146 g. Rats were appropriated into 6 groups (n = 15). Group 1 was provided with normal saline (1 ml/kg) only. Group 2 was induced with RA and untreated. Group 3 was induced and treated with 5 mg/kg indomethacin™ while Groups 4–6 were induced with RA and treated with ELEBC at varied doses of 200, 400, and 800 mg/kg body weight, respectively. Induction of RA was done using Freund’s adjuvant, whereas the route of administration of the standard drug and the extract was via oral intubation. The study period was 31 days.
Results
The chemical composition analysis revealed that ELEBC has a high level of various chemical constituents. The adjuvant injection caused a significant increase in paw sizes plus a reduction in body weight. Levels of creatinine, uric acid, total protein, white blood cell, and total and conjugated bilirubin were significantly elevated in the arthritic rats. There were significant elevations in alkaline phosphatase, alanine aminotransferase, and aspartate aminotransferase activities while the levels of red blood cells, packed cell volume, and hemoglobin were lowered significantly. Treatment with ELEBC markedly reduced the paw sizes and caused weight gain.
Conclusion
Other biochemical dysregulations were also ameliorated. Thus, ELEBC may be useful in the control of RA.
RETRACTED: Biofluorescence imaging system (BIS) Guided surgery for MRONJ: A Case Series on the Preservation of Teeth and Implants
Authors: Park Sang-Hee , Jee Hyouk Keun , Yoon Hong-Cheol , Yun Pil-Young , Ku Jeong-Kui 
Published: July 2024

Abstract

The authors have requested that this preprint be removed from Research Square.
Malaria Rapid Diagnostic Tests: very low prevalence of Plasmodium falciparum histidine-rich protein 2 (pfhrp2) deletion in the Brazil-Venezuela-Guyana tri-border
Authors: Mascarenhas Maria Eduarda Pereira , Louzada Jaime , Rosa Renato Amorim , Assis Gabriela Maíra Pereira , Kano Flora Satiko , Ferreira Joseli Oliveira , de Sousa Tais Nobrega 
Published: July 2024

Abstract

Rapid Diagnostic Tests (RDTs) have been an important diagnostic tool for detecting P. falciparum malaria in resource-limited settings. Most tests are designed to detect the Histidine-rich Protein 2 (HRP2). Parasites lacking pfhrp2 and its homologous pfhrp3 have been reported in several regions, with prevalence reaching 100% in certain areas. To better characterize P. falciparum isolates circulating in the Brazil-Venezuela-Guyana tri-border region, we performed a comprehensive analysis of 365 samples collected between 2016 and 2018. Molecular and immunological methods were employed to detect HRP2 and confirm pfhrp2/3 deletion. Our findings point to a low prevalence (1%) of pfhrp2-deleted parasites confirmed by the lack of HRP2 detection. Among false-negative HRP2-RDT tests (6%), most were attributed to low parasite densities. A merozoite surface protein 2 (msp2)-based intra-host diversity analysis suggested overall low genetic diversity. The pattern of HRP2 sequences resembled that has been previously described in areas along the Brazil and French Guiana border. In conclusion, we have found a low prevalence of pfhrp2-deleted parasites in the north-central Guiana Shield, which contrasts with the findings reported at the Peru border. Continued surveys are necessary to monitor the prevalence of pfhrp2 deletion in this area characterized by a high number of cross-border malaria cases.
Mouthwashes used in patients with oral and oropharyngeal mucositis: A systematic review
Authors: Costa Fernanda Pereira Delgado , Dias Maria Luisa Leandro Souza , Rodrigues Karla Emília , Abreu Lucas Guimarães , Silva Tarcília Aparecida , Travassos Denise Vieira 
Published: July 2024

Abstract

Purpose
The aim of this study was to conduct a systematic review of randomized clinical trials in order to assess the efficacy of the following mouthwashes recommended for the prevention and treatment of OM and OPM in patients undergoing cancer treatment: chlorhexidine, allopurinol, benzydamine, and propolis.
Methods
The following research question was formulated based on the PICOS strategy: “Are chlorhexidine, allopurinol, benzydamine and propolis mouthwashes effective in preventing and treating OM and OPM in patients undergoing cancer treatment?” Searches were performed in PubMed, Embase, Scopus, and Web of Science, without publication year or language restrictions. Randomized clinical trials comparing the use of chlorhexidine, allopurinol, benzydamine and propolis with a control group not submitted to any intervention were included. The retrieved articles were analyzed and selected by two reviewers and disagreements were resolved by consultation with a third reviewer. After data extraction, two evaluators independently analyzed the methodological quality of the studies using the Cochrane tool.
Results
After evaluation of the works, 13 of 1183 articles were selected. mouthwashes containing propolis and benzydamine mouthwashes were promising and effective while chlorhexidine or allopurinol did not provide satisfactory results.
Conclusion
Mouthwashes could be an alternative for treatment or preventing oral mucositis in cancer patients Services could consider the possibility of incorporating these medications since, in most cases, they are low cost and donot require specialized staff in their use.
Predicting MGMT Methylation in Glioblastoma for Informed Clinical Decisions: An AI-Driven Approach in Resource-Limited Settings
Authors: Restini Felipe Cicci Farinha , Torfeh Tarraf , Aouadi Souha , Hammoud Rabih , Al-Hammadi Noora , Starling Maria Thereza Mansur , Souza Cecília Felix Penido Mendes , Mancini Anselmo , Brito Leticia Hernandes , Yoshimoto Fernanda Hayashida , Lima-Júnior Nildevande Firmino , Queiroz Marcelo Moro , Passos Ula Lindoso , Amancio Camila Trolez , Takahashi Jorge Tomio , Delgado Daniel De Souza , Hanna Samir Abdallah , Marta Gustavo Nader , Neves-Junior Wellington Furtado Pimenta 
Published: July 2024

Abstract

Background
Glioblastoma is an aggressive brain cancer with a poor prognosis. MGMT (O6-methylguanine-DNA methyltransferase) gene methylation status is crucial for treatment stratification, yet economic constraints often limit access. This study aims to develop an artificial intelligence (AI) framework for predicting MGMT methylation status.
Methods
Machine learning (ML) and deep learning (DL) techniques were applied to diagnostic MR images from the NIH and a private institution. The images were segmented according to ESTRO-ACROP 2016 guidelines for radiotherapy treatment volumes and combined, with clinical evaluations from neuroradiology experts. Radiomic features (quantitative) and clinical impressions (qualitative) were extracted for ML models. Feature selection methods were used to identify relevant phenotypes for training and validation with ML classifiers.
Results
We evaluated 100 patients from the NIH and 46 patients from a local institution. A total of 343 features were extracted. Eight feature selection methods produced seven independent predictive frameworks. The top-performing ML models included Recursive Feature Elimination (RFE) combined with Linear Discriminant Analysis (LDA) (accuracy of 0.75). DL performance achieved an accuracy of 0.74 using convolutional networks.
Conclusion
This study demonstrates that integrating clinical and radiotherapy-derived AI-driven phenotypes can accurately predict MGMT methylation. The framework also addresses constraints that limit molecular diagnosis access.