bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of NSAID Use Among Colorectal Cancer Survivors on Cancer Outcomes
Authors: Johnson Christine C. , Jankowski Michelle , Rolnick Sharon , Yood Marianne Ulcickas , Alford Sharon Hensley 
Published: December 2014

Purpose:
Colorectal cancer (CRC) is the third most common cancer diagnosed in men and women in the United States. Given the availability of effective screening, most tumors are found early enough to offer patients substantial long-term survival. Thus there is a resulting significant population of CRC survivors for whom modifiable risk factors for recurrence and survival would be of interest.

Methods:
We conducted a population-based retrospective cohort study among patients enrolled in 2 large Midwestern health plans for which claims data, including pharmacy fill data, and medical record data were available. Men and women who were 40 years of age or older at the time of CRC diagnosis with disease less than stage IV and no history of Crohn disease, ulcerative colitis, and irritable bowel syndrome were included. CRC cases diagnosed between January 1, 1990 and December 31, 2000 were included if they met the inclusion criteria. Adjusted Cox proportional hazard models were used with exposure modeled as a time-dependent covariate. We assessed progression-free survival, defined as an aggressive polyp or invasive disease, and overall survival.

Results:
After adjustment for age at diagnosis, sex, race, body mass index, stage, side of initial tumor, and tumor histology, we found that current users of nonsteroidal anti-inflammatory drugs had a 3-fold decreased risk of recurrence and a >7-fold decreased risk of death. Our results are statistically significant with P-values <0.05.

Conclusions:
Our results suggest that current use of nonsteroidal anti-inflammatory drugs provides significant improvements in CRC outcomes.
Resection of Colorectal Cancer With Versus Without Preservation of Inferior Mesenteric Artery
Authors: Mihara Yoshiaki , Kochi Mitsugu , Fujii Masashi , Kanamori Noriaki , Funada Tomoya , Teshima Youichi , Jinno Daijo , Takayama Tadatoshi 
Published: December 2014

Objective:
To assess the clinical significance of preservation of the inferior mesenteric artery (IMA) in comparison with IMA ligation in surgery for sigmoid colon or rectal (colorectal) cancer.

Methods:
Consecutive patients (n=862) with colorectal cancer who underwent intended surgical resection of the main tumor between 1986 and 2011 were retrospectively analyzed. The patients were divided into 2 groups: IMA preserved (n=745) and IMA ligated (n=117).

Results:
No significant difference was observed in incidence of advanced stage III or IV disease between the 2 groups (P=0.56 and 0.51, respectively), whereas a longer operation time (287 [95 to 700] vs. 215 [60 to 900] min, respectively; P<0.001) and greater amount of intraoperative bleeding (595 [15 to 4530] vs. 235 [1 to 11565] mL, respectively; P<0.001) were observed in the IMA-ligated group. The overall incidence of surgery-related complications was higher in the IMA-ligated group than in the IMA-preserved group (53.0% vs. 38.5%, respectively; P=0.003). Urinary dysfunction and abdominal abscess were significantly more frequent in the IMA-ligated group (11.1% vs. 4.0%, P=0.001; and 6.8% vs. 2.6%, P=0.01, respectively), and postoperative hospitalization was longer (11 to 140, median 28 vs. 5 to 153, median 19 d, respectively; P<0.001). No significant difference was found in overall survival rate between the 2 groups.

Conclusions:
For colorectal cancer resection, IMA preservation may be no change to IMA ligation as to patient’ survival, with small risk of operative morbidity.
Reproductive workers show queen-like gene expression in an intermediately eusocial insect, the buff-tailed bumble beeBombus terrestris
Authors: Harrison MC , Hammond RL , Mallon EB 
Published: December 2014

AbstractBumble bees represent a taxon with an intermediate level of eusociality within Hymenoptera. The clear division of reproduction between a single founding queen and the largely sterile workers is characteristic for highly eusocial species, whereas the morphological similarity between the bumble bee queen and the workers is typical for more primitively eusocial hymenopterans. Also, unlike other highly eusocial hy-menopterans, division of labour among worker sub-castes is plastic and not predetermined by morphology or age. We conducted a differential expression analysis based on RNA-seq data from 11 combinations of developmental stage and caste to investigate how a single genome can produce the distinct castes of queens, workers and males in the buff-tailed bumble beeBombus terrestris. Based on expression patterns, we found males to be the most distinct of all adult castes (2,411 transcripts differentially expressed compared to non-reproductive workers). However, only relatively few transcripts were differentially expressed between males and workers during development (larvae: 71, pupae: 162). This indicates the need for more distinct expression patterns to control behaviour and physiology in adults compared to those required to create different morphologies. Among female castes, reproductive workers and their non-reproductive sisters displayed differential expression in over ten times more transcripts compared to the differential expression found between reproductive workers and their mother queen. This suggests a strong shift towards a more queen-like behaviour and physiology when a worker becomes fertile. This contrasts with eusocial species where reproductive workers are more similar to non-reproductive workers than the queen.
High Light-Dependent Phosphorylation of Photosystem II Inner Antenna CP29 in Monocots Is STN7 Independent and Enhances Nonphotochemical Quenching
Authors: Betterle Nico , Ballottari Matteo , Baginsky Sacha , Bassi Roberto 
Published: December 2014

Abstract
Phosphorylation of the photosystem II antenna protein CP29 has been reported to be induced by excess light and further enhanced by low temperature, increasing resistance to these stressing factors. Moreover, high light-induced CP29 phosphorylation was specifically found in monocots, both C3 and C4, which include the large majority of food crops. Recently, knockout collections have become available in rice (Oryza sativa), a model organism for monocots. In this work, we have used reverse genetics coupled to biochemical and physiological analysis to elucidate the molecular basis of high light-induced phosphorylation of CP29 and the mechanisms by which it exerts a photoprotective effect. We found that kinases and phosphatases involved in CP29 phosphorylation are distinct from those reported to act in State 1-State 2 transitions. In addition, we elucidated the photoprotective role of CP29 phosphorylation in reducing singlet oxygen production and enhancing excess energy dissipation. We thus established, in monocots, a mechanistic connection between phosphorylation of CP29 and nonphotochemical quenching, two processes so far considered independent from one another.
Impact of Commercial Precooking of Common Bean (Phaseolus vulgaris) on the Generation of Peptides, After Pepsin–Pancreatin Hydrolysis, Capable to Inhibit Dipeptidyl Peptidase‐IV
Authors: Mojica Luis , Chen Karen , de Mejía Elvira González 
Published: December 2014

AbstractThe objective of this research was to determine the bioactive properties of the released peptides from commercially available precook common beans (Phaseolus vulgaris). Bioactive properties and peptide profiles were evaluated in protein hydrolysates of raw and commercially precooked common beans. Five varieties (Black, Pinto, Red, Navy, and Great Northern) were selected for protein extraction, protein and peptide molecular mass profiles, and peptide sequences. Potential bioactivities of hydrolysates, including antioxidant capacity and inhibition of α‐amylase, α‐glucosidase, dipeptidyl peptidase‐IV (DPP‐IV), and angiotensin converting enzyme I (ACE) were analyzed after digestion with pepsin/pancreatin. Hydrolysates from Navy beans were the most potent inhibitors of DPP‐IV with no statistical differences between precooked and raw (IC50 = 0.093 and 0.095 mg protein/mL, respectively). α‐Amylase inhibition was higher for raw Red, Navy and Great Northern beans (36%, 31%, 27% relative to acarbose (rel ac)/mg protein, respectively). α‐Glucosidase inhibition among all bean hydrolysates did not show significant differences; however, inhibition values were above 40% rel ac/mg protein. IC50 values for ACE were not significantly different among all bean hydrolysates (range 0.20 to 0.34 mg protein/mL), except for Red bean that presented higher IC50 values. Peptide molecular mass profile ranged from 500 to 3000 Da. A total of 11 and 17 biologically active peptide sequences were identified in raw and precooked beans, respectively. Peptide sequences YAGGS and YAAGS from raw Great Northern and precooked Pinto showed similar amino acid sequences and same potential ACE inhibition activity. Processing did not affect the bioactive properties of released peptides from precooked beans. Commercially precooked beans could contribute to the intake of bioactive peptides and promote health.
Telepsychology in Australia: 2020 vision
Authors: Simpson Susan , Reid Corinne 
Published: December 2014

AbstractThe current roll‐out of broadband across Australia provides new opportunities for psychologists to reach out to residents in remote and rural areas. With the advent of internet protocol (IP)‐based videoconferencing, telepsychology is becoming more accessible and affordable, and a potential solution to those in remote areas who require access to specialist assessment and psychotherapy services. Telepsychology represents a high‐quality/low‐cost model of service delivery. Findings to date suggest that outcome might be equivalent to in‐person therapy across a range of client groups both using standardised assessments and evidence‐based therapies. Studies have consistently shown that clients rate high levels of satisfaction and therapeutic rapport. However, uptake among psychologists has been slow. This article provides a synthesis of the gradual growth of telepsychology in Australia. It identifies factors that hinder the development of telepsychology and outlines the main arguments for developing this as a model for the provision of psychology across remote and rural Australia.The authors draw on their own recent experiences in developing collaborative telepsychology services to make recommendations for the future of telepsychology in Australia.
Therapeutic alliance in videoconferencing psychotherapy: A review
Authors: Simpson Susan G. , Reid Corinne L. 
Published: December 2014

AbstractPsychotherapy services are limited in remote and rural areas in Australia and across the globe. Videoconferencing has become well established as a feasible and acceptable mode of psychological treatment delivery. Therapeutic alliance (TA) is an essential factor underlying successful therapy across therapeutic models. In order to determine the state of knowledge regarding TA in psychotherapy via videoconferencing, a literature review was conducted on research studies that formally measured TA as primary, secondary or tertiary outcome measures over the past 23 years. The databases searched were Medline, PsycArticles, PsycINFO, PsycEXTRA and EMBASE. Searching identified 9915 articles that measured satisfaction, acceptability or therapeutic rapport, of which 23 met criteria for the review. Three studies were carried out in Australia, 11 in USA, 4 in Canada, 3 in Scotland and 2 in England. Studies overwhelmingly supported the notion that TA can be developed in psychotherapy by videoconference, with clients rating bond and presence at least equally as strongly as in‐person settings across a range of diagnostic groups. Therapists also rated high levels of TA, but often not quite as high as that of their clients early in treatment. The evidence was examined in the context of important aspects of TA, including bond, presence, therapist attitudes and abilities, and client attitudes and beliefs. Barriers and facilitators of alliance were identified. Future studies should include observational measures of bond and presence to supplement self‐report.
Rêve Général Illimité?The Role of Creative Protest in Transforming the Dynamics of Space and Time During the 2012 Quebec Student Strike
Authors: Spiegel Jennifer Beth 
Published: December 2014

AbstractIn the spring of 2012, students in Quebec went on strike against a proposed 75% increase in university tuition and the further privatization of education that it signaled. The strike lasted 6 months and repeatedly mobilized hundreds of thousands of students and supporters in collective action. Emphasizing the “broader dreams of a student movement now sparking the popular imagination”, some activists began calling for a “rêve général illimité” (unlimited general dream). This article brings together scholarship on creative tactics and the role of space in protest to analyze a range of imaginative and affective interventions as well as the debates that emerged concerning their role within the movement. I argue that creative tactics intervened in how space and time were constructed by altering the relationships amongst private and public space. As a result, responsibilities were redistributed and time typically consecrated to the pursuit of private ends was redeployed during the Quebec student strike, broadening participation and generating public spaces where care was collectivized.
Regeneration of corneal epithelium utilizing a collagen vitrigel membrane in rabbit models for corneal stromal wound and limbal stem cell deficiency
Authors: Chae J. Jeremy , McIntosh Ambrose Winnette , Espinoza Freddy A. , Mulreany Daniel G. , Ng Shengyong , Takezawa Toshiaki , Trexler Morgana M. , Schein Oliver D. , Chuck Roy S. , Elisseeff Jennifer H. 
Published: December 2014

AbstractPurposeThis study was performed to evaluate the potential of a collagen‐based membrane, collagen vitrigel (CV), for reconstructing corneal epithelium in the stromal wound and limbal stem cell deficiency (LSCD) models.MethodsThree groups of rabbits were used in the stromal wound model: CV affixed using fibrin glue (CV + FG group, n = 9), fibrin glue only (FG group, n = 3) and an untreated control group (n = 3). In the LSCD model, one group received CV containing human limbal epithelial cells (CV + hLEC group, n = 2) and the other was an untreated control (n = 1). Gross observation, including fluorescent staining, pathological examination, immunohistochemistry and electron microscopy, was used to evaluate the effect of CV on the corneal epithelium.ResultsIn the stromal wound model, fluorescent staining showed that epithelial reconstruction occurred as rapidly in the CV + FG group as it did in the control group. The pathological examination proved that the CV supported a healthy corneal epithelium in the CV + FG group, whereas FG led to hypertrophy and inappropriate differentiation of corneal epithelium in the FG group. In the LSCD model, the corneas in the CV + hLEC group showed sustained tissue transparency with good epithelialization, low inflammatory response and reduced neovascularization. However, the control cornea was translucent and showed high amounts of inflammation and neovascularization.ConclusionWe have demonstrated that CV supports corneal epithelial differentiation and prevents epithelial hypertrophy, in addition to serving as a scaffold for hLEC transplantation, without complications.
Clinical, biochemical and histological differences between HIV‐associated NAFLD and primary NAFLD: a case–control study
Authors: Vodkin I. , Valasek M. A. , Bettencourt R. , Cachay E. , Loomba R. 
Published: December 2014

SummaryBackgroundThere are limited data regarding the clinical, biochemical and liver histological characteristics of patients with HIV‐associated nonalcoholic fatty liver disease (NAFLD), and whether this entity differs in presentation and severity from primary NAFLDAimTo examine the clinical and histological differences between HIV‐associated NAFLD and primary NAFLD.MethodsThis is a cross‐sectional, case–control study comparing patients with HIV‐associated NAFLD vs. patients with primary NAFLD. HIV‐infected patients were identified from a database of consecutive liver biopsies performed at the University of California at San Diego, over a 13‐year period. HIV‐infected patients with biopsy‐proven NAFLD were selected as cases, after exclusion of other causes of liver disease and hepatic steatosis. Age–sex‐matched controls with biopsy‐proven primary NAFLD were randomly identified from the same pathology database. All biopsies underwent a standardised, detailed, histological research evaluation by a liver pathologist who was blinded to clinical and case–control status.ResultsCompared to age–sex‐matched patients with primary NAFLD (n = 33), patients with HIV‐associated NAFLD (n = 33) had significantly higher mean aspartate aminotransferase (P < 0.001), alanine aminotransferase (P < 0.001), alkaline phosphatase (P = 0.003) and serum triglycerides (P = 0.024). Similarly, compared to age–sex‐matched primary NAFLD, patients with HIV‐associated NAFLD had significantly higher rates of definite steatohepatitis (37% vs. 63%, P = 0.04), and more features of liver injury, including lobular inflammation (<0.001) and acidophil bodies (<0.001).ConclusionCompared to age–sex‐matched primary NAFLD, HIV‐associated NAFLD has increased severity of liver disease and a higher prevalence of NASH.
Commercial cuts and chemical and sensory attributes of meat from crossbred Boer goats fed sunflower cake‐based diets
Authors: Oliveira Ronaldo Lopes , Palmieri Adriana Dantas , Carvalho Silvana Teixeira , Leão André Gustavo , de Abreu Claudilene Lima , Ribeiro Claudio Vaz Di Mambro , Pereira Elzania Sales , de Carvalho Gleidson Giordano Pinto , Bezerra Leilson Rocha 
Published: December 2014

AbstractThis study aimed to evaluate sunflower cake feed in commercial cut yields and chemical and sensory attributes of goat meat. Thirty‐two castrated male goats were distributed in four levels (0, 8, 16 and 24%) of sunflower cake supplementation. The animals were slaughtered and the carcasses were placed in a cold chamber and sectioned into five anatomical regions corresponding to commercial cuts. Samples of the Longissimus lumborum muscle were analyzed for chemical composition and sensory quality. The chemical composition and pH were not affected by the treatments. The smell, taste and ‘goatiness’ of the aroma and flavor of the meat were also unaffected by the treatments. The appearance, tenderness and juiciness of the meat differed by treatment. The highest level (24%) of sunflower cake increased meat tenderness; however, according to the tasters there was reduced softness, although none of the samples were rejected by the tasters. Sunflower cake can be added to the diet at a level of up to 16% without altering the quantitative and qualitative attributes of the meat.
Incidence of food anaphylaxis in people with food allergy: a systematic review and meta‐analysis
Authors: Umasunthar T. , Leonardi‐Bee J. , Turner P. J. , Hodes M. , Gore C. , Warner J. O. , Boyle R. J. 
Published: December 2014

SummaryBackgroundFood allergy is a common cause of anaphylaxis, but the incidence of anaphylaxis in food allergic people is unknown.MethodsWe undertook a systematic review and meta‐analysis, using the inverse variance method. Two authors selected studies by consensus, independently extracted data and assessed study quality using the Newcastle–Ottawa assessment scale. We searched Medline, Embase, PsychInfo, CINAHL, Web of Science, LILACS and AMED between January 1946 and September 2012 and recent conference abstracts. We included registries, databases or cohort studies which described the number of food anaphylaxis cases in a defined population and time period and applied an assumed population prevalence of food allergy.ResultsWe included data from 34 studies. There was high heterogeneity between study results, possibly due to variation in study populations, anaphylaxis definition and data collection methods. In food allergic people, medically coded food anaphylaxis had an incidence rate of 0.14 per 100 person‐years (95% CI 0.05, 0.35; range 0.01, 1.28). In sensitivity analysis using different estimated food allergy prevalence, the incidence varied from 0.11 to 0.21 per 100 person‐years. At age 0–19, the incidence rate for anaphylaxis in food allergic people was 0.20 (95% CI 0.09, 0.43; range 0.01, 2.55; sensitivity analysis 0.08, 0.39). At age 0–4, an incidence rate of up to 7.00 per 100 person‐years has been reported. In food allergic people, hospital admission due to food anaphylaxis had an incidence rate of 0.09 (95% CI 0.01, 0.67; range 0.02, 0.81) per 1000 person‐years; 0.20 (95% CI 0.10, 0.43; range 0.04, 2.25) at age 0–19 and 0.50 (0.26, 0.93; range 0.08, 2.82) at age 0–4.ConclusionIn food allergic people, the incidence of food allergic reactions which are coded as anaphylaxis by healthcare systems is low at all ages, but appears to be highest in young children.
Biofilm removal from implants supported restoration using different instruments: a 6‐month comparative multicenter clinical study
Authors: Blasi Andrea , Iorio‐Siciliano Vincenzo , Pacenza Carina , Pomingi Francesca , Matarasso Sergio , Rasperini Giulio 
Published: December 2014

AbstractObjectivesThe aim of this study was to compare the efficacy of different instruments on biofilm removal from implant supported restorations.Materials and methodsThe study was designed as comparative multicenter clinical study including patients proceeding from the Milan, Naples, and Buenos Aires, with a peri‐implant mucositis.Implants enrolled for the study were allocated in 4 groups and treated with ultrasonic scalers with plastic tips, with titanium curettes, with airflow with glycine powder, and with rubber cup and polishing paste, respectively.mPI was assessed at baseline, immediately after therapy, at 1, 3, and 6 months. mBI, PD, and REC were assessed at baseline, 1, 3, and 6 months. All parameters were recorded on six sites per implant.Kruskal–Wallis and Mann–Whitney tests were used to compare groups and centers. A generalized linear model for repeated measures was chosen for inter‐group comparison. An intra‐group comparison was performed with repeated measure ANOVA test to assess differences between baseline and recalls.ResultsA total of 89 patients (39 males, 50 females) were enrolled in the study, and 141 implants were available for the analysis. 55 implants were enrolled in University of Buenos Aires, 32 in University of Milan, and 54 in University of Naples. There were no significant differences between the four groups in inflammatory status reduction of peri‐implant mucosa.ConclusionsNon‐surgical therapy is effective in reducing peri‐implant mucositis. Sonic scaler with plastic tip and rubber cup with polishing paste showed higher efficacy when compared with titanium curettes or airflow with glycine powder.