bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effects of stress and relaxation on pain perception in subjects with pain‐free occlusional disharmony compared with healthy controls
Authors: Ruscheweyh R , Becker T , Born Y , Çolak‐Ekici R , Marziniak M , Evers S , Gerlach AL , Wolowski A 
Published: October 2014

ObjectivesThe significance of occlusal disharmony for the development of painful temporomandibular disorder (TMD) is controversial. The ongoing biomechanical strain caused by occlusal disharmony might lead to sensitization processes in the nociceptive system. Understanding these processes might be an important step toward understanding the possible relationship between occlusal disharmony and TMD. In this study, we therefore investigated whether subjects with occlusal disharmony (n = 22) differ from healthy controls (n = 26) in their pain perception and pain modulation by stress and relaxation.Materials and MethodsTrigeminal and extratrigeminal experimental pain perception (pinprick, heat, and pressure pain) was assessed before and after stress (mental arithmetic) and relaxation (viewing of low‐arousal pictures).ResultsThere were no group differences in pain perception at baseline or during the stress task. Compared with controls, the occlusal disharmony group exhibited an inadequate reduction in pain perception during relaxation, which was significant for the extratrigeminal site (P < 0.01) and reached a trend for significance at the trigeminal site (P = 0.1).ConclusionsThese results suggest that subjects with occlusal disharmony show signs of disturbed endogenous pain inhibition during relaxation.Clinical RelevanceThere is evidence for the presence of sensitization of the nociceptive system in subjects with occlusal disharmony. Possibly, deficient inhibition of extratrigeminal and trigeminal pain perception by relaxation might contribute to the development of TMD or other chronic pain disorders.
The Vindolanda Timepiece: Time and Calendar Reckoning in Roman Britain
Authors: Birth Kevin K. 
Published: October 2014

SummaryIn 2008 a fragment of a time‐reckoning device was found at Vindolanda. This fragment has been interpreted as part of an anaphoric water clock. There are important differences between this fragment and other objects thought to come from anaphoric water clocks. This article seeks to reinterpret the fragment in terms of a broader array of Roman time‐reckoning tools than anaphoric water clocks and also in terms of the archaeological context of Vindolanda in which the fragment was found. The emphasis on cultural context in interpreting this fragment reveals much about the temporal consciousness of its possible users and maker.
Temperature requirements for growth and maturation of the warm temperate kelp Eckloniopsis radicosa (Laminariales, Phaeophyta)
Authors: Komazawa Ichiro , Sakanishi Yoshihiko , Tanaka Jiro 
Published: October 2014

SummaryThe annual kelp Eckloniopsis radicosa is distributed along Japanese coasts and occurs within the area with a February isotherm ranging 15–18°C and August isotherm ranging 25–28°C. In this study, the effects of temperature on the gametophyte growth and maturation, and the young sporophyte growth of E. radicosa were examined and the results are discussed in relation to the distribution of other warm‐adapted kelp species and the potential effects of climate change. The optimal temperature ranges for growth of male and female gametophytes were 23–27°C and 20–26°C, respectively. The upper survival temperature for gametophyte growth was 31°C for males and 30°C for females, respectively. The optimal temperature range for maturation of female gametophytes was ≤23°C. The optimal temperature range for growth of young sporophytes was 14–22°C. It was clarified that E. radicosa has the most warm‐adapted characteristics for growth and maturation of gametophytes among members of the Laminariales studied so far. The natural seawater temperature ranges during the growth and maturation seasons for gametophytes of E. radicosa, as well as the growth season for young sporophytes near to the northern and southern distribution limits (Izu‐Oshima: 14.9–24.5°C, Ichiki‐kushikino: 17.1–29.6°C), agreed with the experimentally determined temperature requirements. The warm‐adapted gametophyte stage and annual lifecycle are major factors enabling survival of E. radicosa in warm waters near tropical regions along the Japanese coast.
Molecular alterations in non‐small‐cell lung cancer: Perspective for targeted therapy and specimen management for the bronchoscopist
Authors: Czarnecka‐Kujawa Kasia , Yasufuku Kazuhiro 
Published: October 2014

AbstractMajor advances have occurred over the past decade in our understanding of lung cancer pathobiology. Increasing knowledge of molecular aberrations in lung cancer, specifically the discovery of two driver genes in pharmacologically targetable tyrosine kinases involved in growth factor receptor signalling, epidermal growth factor receptor and anaplastic lymphoma kinase, has been of major therapeutic and prognostic importance. This discovery has allowed for new, personalized approach to the management of lung cancer. Recognizing the importance of molecular signatures of lung cancer, the College of American Pathologists, International Association for the Study of Lung Cancer and Association for Molecular Pathology released the first guidelines for molecular testing in lung cancer.The introduction of minimally invasive needle techniques for the evaluation of lung cancer patients, such as endobronchial ultrasound transbronchial needle aspiration and oesophageal ultrasound–fine‐needle aspiration, has revolutionized the way lung cancer patients are assessed. Samples obtained using the minimally invasive needle approaches have been shown to be sufficient not only for routine molecular testing but also for multigenic analysis. This allows bronchoscopist to assume an increasingly important role in the diagnostic workup of patients with lung cancer at all stages of the disease and contribute to personalizing the care of lung cancer patients.
A Sticky Information Phillips Curve for South Africa
Authors: Reid Monique , du Rand Gideon 
Published: October 2014

AbstractMankiw and Reis propose the Sticky Information Phillips Curve (SIPC) as an alternative to the standard New Keynesian Phillips Curve to address empirical shortcomings in the latter. A SIPC for South Africa is estimated, and we find estimates of information updating probability between 0.69 and 0.81, somewhat higher than suggested by methods using micro‐evidence. Because the estimation requires data on expectations of current period inflation and output gap conditional on sequences of earlier period information sets, we provide a detailed analysis of the impact on our estimates of alternative proxies available in South Africa.
Seasonal dynamics in wheel load‐carrying capacity of a loam soil in the Swiss Plateau
Authors: Gut S. , Chervet A. , Stettler M. , Weisskopf P. , Sturny W. G. , Lamandé M. , Schjønning P. , Keller T. 
Published: October 2014

AbstractSubsoil compaction is a major problem in modern agriculture caused by the intensification of agricultural production and the increase in weight of agricultural machinery. Compaction in the subsoil is highly persistent and leads to deterioration of soil functions. Wheel load‐carrying capacity (WLCC) is defined as the maximum wheel load for a specific tyre and inflation pressure that does not result in soil stress in excess of soil strength. The soil strength and hence WLCC is strongly influenced by soil matric potential (h). The aim of this study was to estimate the seasonal dynamics in WLCC based on in situ measurements of h, measurements of precompression stress at various h and simulations of soil stress. In this work, we concentrated on prevention of subsoil compaction. Calculations were made for different tyres (standard and low‐pressure top tyres) and for soil under different tillage and cropping systems (mouldboard ploughing, direct drilling, permanent grassland), and the computed WLCC was compared with real wheel loads to obtain the number of trafficable days (NTD) for various agricultural machines. Wheel load‐carrying capacity was higher for the top than the standard tyres, demonstrating the potential of tyre equipment in reducing compaction risks. The NTD varied between years and generally decreased with increasing wheel load of the machinery. The WLCC simulations presented here provide a useful and easily interpreted tool to guide the avoidance of soil compaction.
Forms of Al in soil and soil solution in a long‐term fertilizer application experiment
Authors: Rutkowska B. , Szulc W. , Hoch M. , Spychaj‐Fabisiak E. 
Published: October 2014

AbstractUnder the conditions of a long‐term fertilizer experiment, this study aimed to determine the contents of total and exchangeable aluminium in soil as well as the Al concentration in the soil solution. Additionally, Al speciation was evaluated with the use of the MINTEQA2 software. The results obtained indicated that under the conditions of long‐term application of different mineral fertilizers or farmyard manure, the soil reaction changed to a great extent (pH 3.58–6.78). At the same time, the content of total Al in soil fluctuated from 18.85 to 22.13 g/kg and that of exchangeable Al ranged from 1.42 to 102.66 mg/kg. The concentration of Al in the soil solution was highly differentiated (5.19–124.07 μmol/L) as well as that of free aluminium ions (Al3+) (0–16.9 μmol/L). In acidic soils, aluminium complexes with organic matter are the predominant forms of Al in the soil solution. In soils with neutral soil reaction, there were no free aluminium ions. Soil liming and addition of organic amendment were the treatments that restricted the presence of toxic aluminium forms in soil.
Draft Genome Sequence of Antagonistic Agent Lysobacter antibioticus 13-6
Authors: Zhou Lihong , Li Miao , Yang Jun , Wei Lanfang , Ji Guanghai 
Published: October 2014

ABSTRACT

Lysobacter antibioticus
13-6, isolated from the roots of Chinese cabbage, effectively controls the pathogens
Plasmodiophora brassicae
,
Xanthomonas oryzae
pv. oryzicola,
X. oryzae
pv. oryzae,
Xanthomonas axonopodis
pv. dieffenbachiae, and
Pseudomonas syringae
pv. tabaci. We report the first draft genome sequence of the
L. antibioticus
species in China.
Genome Sequences of Parvovirus B19 Reference Strains
Authors: Trösemeier Jan-Hendrik , Branting Annika , Lukashov Vladimir V. , Blümel Johannes , Baylis Sally A. 
Published: October 2014

ABSTRACT
We report here the sequences of two reference strains of parvovirus B19 (B19V) used for quantitation of B19V DNA. One reference strain has been established by the World Health Organization (WHO) and the other by the European Pharmacopeia (Ph. Eur.) and belong to B19V genotype 1a1 and 1a2, respectively.
Draft Whole-Genome Sequences of Three Shiga Toxin-Producing Escherichia coli O91:H21 Isolates, Two from Hemolytic Uremic Syndrome Patients and One of Porcine Origin
Authors: Wu Cindy H. , Zhang Peng , Morales Christina Q. , Kiang David 
Published: October 2014

ABSTRACT

This study presents three genomes of O91:H21 isolates, two from hemolytic uremic syndrome patients and one of porcine origin. Genome analyses reveal that one of the human isolates contains both Shiga toxin-encoding genes (
stx
1
and
stx
2
), and all three isolates contain putative adhesin (
iha
and
eaeH
) and antibiotic resistance (
ampC
) genes.
Draft Genome of Chilean Honeybee (Apis mellifera) Gut Strain Lactobacillus kunkeei MP2
Authors: Olmos Alejandro , Henríquez-Piskulich Patricia , Sanchez Carolina , Rojas-Herrera Marcelo , Moreno-Pino Mario , Gómez Marcela , Rodríguez Da Silva Rafael , Maracaja-Coutinho Vinicius , Aldea Patricia , Trombert Annette N. 
Published: October 2014

ABSTRACT

Here, we report the first draft genome sequence of
Lactobacillus kunkeei
strain MP2, isolated from a Chilean honeybee gut. The sequenced genome has a total size of 1.58 Mb distributed into 44 contigs and 1,356 protein-coding sequences.
Genome Sequence of Nitratireductor basaltis Strain UMTGB225, a Marine Bacterium Isolated from a Green Barrel Tunicate in Bidong Island, Malaysia
Authors: Danish-Daniel Muhd , Gan Huan You , Gan Han Ming , Saari Nur Azna , Usup Gires 
Published: October 2014

ABSTRACT

Nitratireductor basaltis
strain UMTGB225 is a Gram-negative bacterium isolated from a marine tunicate found in Bidong Island, Terengganu, Malaysia. In this study, the genome of
Nitratireductor basaltis
UMTGB225 was sequenced to gain insight into the role of this bacterium and its association with tunicate hosts in a coral reef habitat.
Draft Genome Sequence of Thermoanaerobacterium saccharolyticum Strain NTOU1, a Thermophilic Bacterium Isolated from Marine Shallow Hydrothermal Vents
Authors: Tan Engkong , Chen Yusan , Kuan Jung , Lin Chiajui , Jagoda S. S. S. De S. , Lin Fupang , Tzou Wenshyong , Kinoshita Shigeharu , Watabe Shugo , Asakawa Shuichi , Liu Shiumei 
Published: October 2014

ABSTRACT

Thermoanaerobacterium saccharolyticum
strain NTOU1 has the ability to utilize several kinds of sugars in lignocellulosic biomass to produce ethanol more efficiently than other bacteria. Here, we report the draft genome sequence and annotation of this strain, which may provide insights into the possible genes and metabolic pathways related to ethanol production.
Draft Genome Sequence of Rhodococcus erythropolis JCM 6824, an Aurachin RE Antibiotic Producer
Authors: Kitagawa Wataru , Hata Miyako , Sekizuka Tsuyoshi , Kuroda Makoto , Ishikawa Jun 
Published: October 2014

ABSTRACT

Rhodococcus erythropolis
JCM 6824 is the producer of the quinoline antibiotic aurachin RE. This bacterium also degrades and utilizes some aromatic compounds, such as biphenyl and benzoate. Here, we report the draft genome sequence of this strain.
Draft Genome Sequences of Two Antimicrobial-Producing
Burkholderia
sp. Strains, MSh1 and MSh2, Isolated from Malaysian Tropical Peat Swamp Forest Soil
Authors: Ong Kuan Shion , Aw Yoong Kit , Gan Han Ming , Yule Catherine M. , Lee Sui Mae 
Published: October 2014

ABSTRACT

We report the draft genome sequences of two antimicrobial-producing isolates,
Burkholderia
sp. strains MSh1 and MSh2, which were isolated from tropical peat swamp forest soil. Putative genes related to different antimicrobial production have been annotated in both genome sequences.
SelectiveIn VivoImaging of Syngeneic, Spontaneous, and Xenograft Tumors Using a Novel Tumor Cell–Specific Hsp70 Peptide-Based Probe
Authors: Stangl Stefan , Varga Julia , Freysoldt Bianca , Trajkovic-Arsic Marija , Siveke Jens T. , Greten Florian R. , Ntziachristos Vasilis , Multhoff Gabriele 
Published: October 2014

AbstractAlthough in vivo targeting of tumors using fluorescently labeled probes has greatly gained in importance over the last few years, most of the clinically applied reagents lack tumor cell specificity. Our novel tumor cell–penetrating peptide-based probe (TPP) recognizes an epitope of Hsp70 that is exclusively present on the cell surface of a broad variety of human and mouse tumors and metastases, but not on normal tissues. Because of the rapid turnover rate of membrane Hsp70, fluorescently labeled TPP is continuously internalized into syngeneic, spontaneous, chemically/genetically induced and xenograft tumors following intravenous administration, thereby enabling site-specific labeling of primary tumors and metastases. In contrast with the commercially available nonpeptide small molecule αvβ3-integrin antagonist IntegriSense, TPP exhibits a significantly higher tumor-to-background contrast and stronger tumor-specific signal intensity in all tested tumor models. Moreover, in contrast with IntegriSense, TPP reliably differentiates between tumor cells and cells of the tumor microenvironment, such as tumor-associated macrophages and fibroblasts, which were found to be membrane-Hsp70 negative. Therefore, TPP provides a useful tool for multimodal imaging of tumors and metastases that might help to improve our understanding of tumorigenesis and allow the establishment of improved diagnostic procedures and more accurate therapeutic monitoring. TPP might also be a promising platform for tumor-specific drug delivery and other Hsp70-based targeted therapies. Cancer Res; 74(23); 6903–12. ©2014 AACR.
Dietary Intake of Acrylamide and Epithelial Ovarian Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort
Authors: Obón-Santacana Mireia , Peeters Petra H.M. , Freisling Heinz , Dossus Laure , Clavel-Chapelon Françoise , Baglietto Laura , Schock Helena , Fortner Renée T. , Boeing Heiner , Tjønneland Anne , Olsen Anja , Overvad Kim , Menéndez Virginia , Sanchez Maria-José , Larrañaga Nerea , Huerta Castaño José María , Barricarte Aurelio , Khaw Kay-Tee , Wareham Nick , Travis Ruth C. , Merritt Melissa A. , Trichopoulou Antonia , Trichopoulos Dimitrios , Orfanos Philippos , Masala Giovanna , Sieri Sabina , Tumino Rosario , Vineis Paolo , Mattiello Amalia , Bueno-de-Mesquita H.B. , Onland-Moret N. Charlotte , Wirfält Elisabeth , Stocks Tanja , Idahl Annika , Lundin Eva , Skeie Guri , Gram Inger T. , Weiderpass Elisabete , Riboli Elio , Duell Eric J. 
Published: October 2014

Abstract
Acrylamide, classified in 1994 by the International Agency for Research on Cancer (IARC) as “probably carcinogenic” to humans, was discovered in 2002 in some heat-treated, carbohydrate-rich foods. The association between dietary acrylamide intake and epithelial ovarian cancer risk (EOC) has been previously studied in one case–control and three prospective cohort studies which obtained inconsistent results and could not further examine histologic subtypes other than serous EOC. The present study was carried out in the European Prospective Investigation into Cancer and Nutrition (EPIC) subcohort of women (n = 325,006). Multivariate Cox proportional hazards models were used to assess the association between questionnaire-based acrylamide intake and EOC risk. Acrylamide was energy-adjusted using the residual method and was evaluated both as a continuous variable (per 10 μg/d) and in quintiles; when subgroups by histologic EOC subtypes were analyzed, acrylamide intake was evaluated in quartiles. During a mean follow-up of 11 years, 1,191 incident EOC cases were diagnosed. At baseline, the median acrylamide intake in EPIC was 21.3 μg/d. No associations and no evidence for a dose–response were observed between energy-adjusted acrylamide intake and EOC risk (HR10μg/d,1.02; 95% CI, 0.96–1.09; HRQ5vsQ1, 0.97; 95% CI, 0.76–1.23). No differences were seen when invasive EOC subtypes (582 serous, 118 endometrioid, and 79 mucinous tumors) were analyzed separately. This study did not provide evidence that acrylamide intake, based on food intake questionnaires, was associated with risk for EOC in EPIC. Additional studies with more reliable estimates of exposure based on biomarkers may be needed. Cancer Epidemiol Biomarkers Prev; 24(1); 291–7. ©2014 AACR.
STING Contributes to Antiglioma Immunity via Triggering Type I IFN Signals in the Tumor Microenvironment
Authors: Ohkuri Takayuki , Ghosh Arundhati , Kosaka Akemi , Zhu Jianzhong , Ikeura Maki , David Michael , Watkins Simon C. , Sarkar Saumendra N. , Okada Hideho 
Published: October 2014

Abstract
Although type I IFNs play critical roles in antiviral and antitumor activity, it remains to be elucidated how type I IFNs are produced in sterile conditions of the tumor microenvironment and directly affect tumor-infiltrating immune cells. Mouse de novo gliomas show increased expression of type I IFN messages, and in mice, CD11b+ brain-infiltrating leukocytes (BIL) are the main source of type I IFNs that are induced partially in a STING (stimulator of IFN genes)-dependent manner. Consequently, glioma-bearing StingGt/Gt mice showed shorter survival and lower expression levels of Ifns compared with wild-type mice. Furthermore, BILs of StingGt/Gt mice showed increased CD11b+ Gr-1+ immature myeloid suppressor and CD25+ Foxp3+ regulatory T cells (Treg) and decreased IFNγ-producing CD8+ T cells. CD4+ and CD8+ T cells that received direct type I IFN signals showed lesser degrees of regulatory activity and increased levels of antitumor activity, respectively. Finally, intratumoral administration of a STING agonist (cyclic diguanylate monophosphate; c-di-GMP) improved the survival of glioma-bearing mice associated with enhanced type I IFN signaling, Cxcl10 and Ccl5, and T-cell migration into the brain. In combination with subcutaneous OVA peptide vaccination, c-di-GMP increased OVA-specific cytotoxicity of BILs and prolonged their survival. These data demonstrate significant contributions of STING to antitumor immunity via enhancement of type I IFN signaling in the tumor microenvironment and suggest a potential use of STING agonists for the development of effective immunotherapy, such as the combination with antigen-specific vaccinations. Cancer Immunol Res; 2(12); 1199–208. ©2014 AACR.
Thrombosis: A major contributor to global disease burden
Authors: Raskob Gary ,   ISTH Steering Committee for World Thrombosis Day
Published: October 2014

SummaryThrombosis is a common pathology underlying ischaemic heart disease, ischaemic stroke, and venous thromboembolism (VTE). The Global Burden of Disease Study 2010 (GBD 2010) documented that ischaemic heart disease and stroke collectively caused one in four deaths worldwide. GBD 2010 did not report data for VTE as a cause of death and disability. We performed a systematic review of the literature on the global disease burden due to VTE in low, middle and high income countries. Studies from Western Europe, North America, Australia, and Southern Latin America (Argentina) yielded consistent results with annual incidences ranging from 0.75 to 2.69 per 1,000 individuals in the population. The incidence increased to between 2 and 7 per 1,000 among those 70 years of age or more. Although the incidence is lower in individuals of Chinese and Korean ethnicity, their disease burden is not low because of population aging. VTE associated with hospitalisation was the leading cause of disability-adjusted-lifeyears (DALYs) lost in low and middle income countries, and second in high income countries, responsible for more DALYs lost than nosocomial pneumonia, catheter-related blood stream infections, and adverse drug events. VTE causes a major burden of disease across low, middle, and high income countries. More detailed data on the global burden of VTE should be obtained to inform policy and resource allocation in health systems, and to evaluate if improved utilisation of preventive measures will reduce the burden.Note: The copyright for the article is being held by the International Society on Thrombosis and Haemostasis under a CC-BY-NC-ND license.