bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary One-Carbon Nutrient Intake and Risk of Lymphoid and Myeloid Neoplasms: Results of the Netherlands Cohort Study
Authors: Heinen Mirjam M. , van den Brandt Piet A. , Schouten Leo J. , Goldbohm R. Alexandra , Schouten Harry C. , Verhage Bas A.J. 
Published: July 2014

Abstract
Background: Previous epidemiologic research suggests a protective role of one-carbon nutrients in carcinogenesis. Folate, however, may play a dual role in neoplasms development: protect early in carcinogenesis and promote carcinogenesis at a later stage. We prospectively examined associations between intake of total folate, methionine, riboflavin, vitamin B6, and risk of lymphoid and myeloid neoplasms (including subtypes) and investigated whether alcohol modified the effects of folate.
Methods: The Netherlands Cohort Study consists of 120,852 individuals who completed a baseline questionnaire in 1986, including a 150-item food-frequency questionnaire. After 17.3 years of follow-up, 1,280 cases of lymphoid and 222 cases of myeloid neoplasms were available for analysis.
Results: Intakes of folate, methionine, and riboflavin were not associated with lymphoid or myeloid neoplasms. For vitamin B6, a statistically significantly increased myeloid neoplasms risk was observed (highest vs. lowest quintile: HR = 1.87; 95% confidence intervals, 1.08–3.25). When analyzing by lymphoid and myeloid neoplasms subtypes, no clear associations were observed for most subtypes, with just a few increased risks for some subtypes and nutrients. Some risks became nonsignificant after excluding early cases. No interaction between alcohol and folate was observed.
Conclusions: We observed a few significant positive associations; however, some of these would be expected to arise due to chance alone. Furthermore, some risks became nonsignificant after excluding early cases. Therefore, we conclude that there is no association between one-carbon nutrient intake and risk of lymphoid and myeloid neoplasms.
Impact: This study contributes substantially to the limited and inconclusive evidence on the association with one-carbon nutrients. Cancer Epidemiol Biomarkers Prev; 23(10); 2153–64. ©2014 AACR.
Single-Nucleotide Polymorphism Data Support the General Unrelatedness of the Males in the Agricultural Health Study
Authors: Jack John R. , Motsinger-Reif Alison A. , Koutros Stella , Alavanja Michael C. , Beane Freeman Laura E. , Hoppin Jane A. 
Published: July 2014

Abstract
Background: Farming is often a family and multigenerational business. Relatedness among farmers could bias gene–environment interaction analysis. To evaluate the potential relatedness of farmers, we used data from a nested case–control study of prostate cancer conducted in the Agricultural Health Study (AHS), a prospective study of farmers in Iowa and North Carolina.
Methods: We analyzed the genetic data for 25,009 SNPs (single-nucleotide polymorphisms) from 2,220 White participants to test for cryptic relatedness among these farmers. We used two software packages: (i) PLINK, to calculate inbreeding coefficients and identity-by-descent (IBD) statistics and (ii) EIGENSOFT, to perform a principal component analysis on the genetic data.
Results: Inbreeding coefficients estimates and IBD statistics show that the subjects are overwhelmingly unrelated, with little potential for cryptic relatedness in these data.
Conclusions: Our analysis rejects the hypothesis that individuals in the case–control study exhibit cryptic relatedness.
Impact: These findings are important for all subsequent analyses of gene–environment interactions in the AHS. Cancer Epidemiol Biomarkers Prev; 23(10); 2192–5. ©2014 AACR.
Systematically Defining Single-Gene Determinants of Response to Neoadjuvant Chemotherapy Reveals Specific Biomarkers
Authors: Witkiewicz Agnieszka K. , Balaji Uthra , Knudsen Erik S. 
Published: July 2014

Abstract
Purpose: We sought to systematically define determinants of the response to neoadjuvant chemotherapy to elucidate predictive biomarkers for breast cancer.
Experimental Design: An unbiased systematic analysis was performed in multiple independent datasets to define genes predictive of complete pathologic response (pCR) following treatment with neoadjuvant chemotherapy. These genes were interrogated across estrogen receptor (ER)–positive and ER-negative breast cancer and those in common across three different treatment regimens were analyzed for optimal predictive power. Subsequent validation was performed on independent cohorts by gene expression and IHC analyses.
Results: Genes that were highly associated with the response to neoadjuvant chemotherapy in breast cancer were readily defined using a computational method ranking individual genes by their respective ROC. Such predictive genes of the response to taxane-associated therapies were strongly enriched for cell-cycle control processes in both ER-positive and ER-negative breast cancer and correlated with pCR. However, other genes that were specifically associated with residual disease were also identified under other treatment conditions. Using the intersection between treatment groups, nine genes were identified that harbored strong predictive power in multiple contexts and validation cohort. In particular, the nuclear oncogene DEK was strongly associated with pCR, whereas the cell surface protein BCAM was strongly associated with residual disease. By IHC staining, these markers exhibited potent predictive power that remained significant in multivariate analysis.
Conclusion: Systematic computational approaches can define key genes that will be able to predict the response to chemotherapy across multiple treatment modalities yielding a small collection of biomarkers that can be readily deployed by IHC analyses. Clin Cancer Res; 20(18); 4837–48. ©2014 AACR.
História e Sobrelevação no Escrito da Diferença
Authors: Valentim Marco Antonio 
Published: July 2014

Esse artigo examina os conceitos de história e sobrelevação (Aufhebung) em conexão com a dialética de razão e entendimento narrada por Hegel no primeiro capítulo do Escrito da Diferença. Assim, na medida em que a sobrelevação, enquanto síntese de intuição e reflexão, constitui o âmbito fundamental da história, como formação do Espírito, a oposição harmônica entre razão e entendimento torna possível a efetivação do saber no sistema, isto é, no modo da comunidade originária de espírito e letra. Trata-se, pois, de indicar o caráter decisivo da forma – ou seja, figura – como a essência mesma do absoluto. O que aqui se procura fazer pela diferença com o sistema de filosofia de Fichte e de Schelling, que representa respectivamente as abstrações da letra sem inspiração e do espírito iletrado.
The Future of Philosophy of History from its Narrativist Past
Authors: La Greca María Inés 
Published: July 2014

Hayden White inaugurated narrativism in philosophy of history when he effected a productive displacement of earlier epistemological discussions around the relationship between narration and historical knowledge: White identified the problem of narrative in history with the problem of the use of figurative language in the representation of the past. Thus, he enabled a new way of thinking philosophy of history’s object of study by paying attention to an aspect of historical practice he considered wrongly overlooked: the writing of history. His formal theory of the historical work needs no introduction. Instead, this paper aims at reclaiming the fundamental philosophical legacy White has left us in his latest work on middle voice writing.
First, I will frame White’s thought as a response to what I call the paradoxical nature of historical narrative, as Louis Mink and Roland Barthes understand it. By presenting our narrativist past as White’s ironical and liberating stance on historical narrative, I will show how he identified figuration as the paradoxical resource and constrain of historical writing. Secondly, I will elaborate on his latest inquiries into middle voice writing as pointing the way into the future of philosophy of history. Thus, I will claim that the notion of middle voice writing that White adopted from Roland Barthes should be read from the point of view of performativity theory in order to reassess the philosophical nature of historical writing now considered as the performative self-constitution of the historical subject.
Truth, Objectivity and Evidence in History Writing
Authors: Tamm Marek 
Published: July 2014

This article aims to suggest one possible – pragmatist in a very broad sense of the term – approach to making sense of the way truth and objectivity function within the discipline of history. It argues that history doesn’t need a new theory of truth; rather, it is necessary to analyse in theoretical terms how truth is understood and used in historical inquiry. This article considers truth as an epistemic term in a certain given – historiographical – use, and objectivity is understood as an epistemic virtue valued in a specific contemporary scientific community, that of professional historians.
The main argument is developed in three interrelated steps. First, the article makes the case for a pragmatic “truth pact” in history writing, arguing that the conditions of historical truth depend on the illocutionary force of historical utterance. Second, it proposes that this “truth pact” is “guaranteed” by fellow historians or, in other words: truth claims in history writing are based not on their direct relation with reality but on a disciplinary consensus as to the methods of inquiry, cognitive values and epistemic virtues. Third, it will establish a clear connection between truth and proof in history writing, arguing that the “truth pact” is grounded in a critical analysis of the available evidence.
Subliming and Subverting
Authors: Chin Chuanfei 
Published: July 2014

What is special about the philosophy of history when the history is about science? I shall focus on an impasse between two perspectives – one seeking an ideal of rationality to guide scientific practices, and one stressing the contingency of the practices. They disagree on what this contingency means for scientific norms. Their impasse underlies some fractious relations within History and Philosophy of Science. Since the late 1960s, this interdisciplinary field has been described, variously, as an “intimate relationship or marriage of convenience”, a “marriage for the sake of reason”, a “troubling interaction”, a “precarious relationship”, or one at risk of “epistemological derangement”.
My paper has three aims. First, I characterise two idealised perspectives in this impasse: the sublimers and subversives. Then I describe a curious dynamic in which each perspective accuses the other of, simultaneously, claiming too little and too much. Subliming is dismissed for being scholastic, and condemned for being imperialist. Subverting is disparaged for being merely sociological, then criticised for being irrational or relativist. Here I draw on and extend the analyses of science studies in Kitcher (1998), Zammito (2011) and others. Second, I argue that sublimers and subversives often talk past each other. Their mutual dismissals and condemnations arise partly because each perspective misconstrues the other’s claims. Each fails to see that the other is interested in different problems and interprets concepts differently. Third, I suggest that my analysis clarifies some current disagreements and old debates about contingency in science. It may also apply to debates on the contingency of norms in non-scientific realms.
Observations of the Origin and Distribution of Ice in Cold, Warm, and Occluded Frontal Systems during the DIAMET Campaign
Authors: Lloyd G. , Dearden C. , Choularton T. W. , Crosier J. , Bower K. N. 
Published: July 2014

Abstract
Three case studies in frontal clouds from the Diabatic Influences on Mesoscale Structures in Extratropical Storms (DIAMET) project are described to understand the microphysical development of the mixed phase regions of these clouds. The cases are a kata-type cold front, a wintertime warm front, and a summertime occluded frontal system. The clouds were observed by radar, satellite, and in situ microphysics measurements from the U.K. Facility for Airborne Atmospheric Measurements (FAAM) research aircraft. The kata cold front cloud was shallow with a cloud-top temperature of approximately −13°C. Cloud-top heterogeneous ice nucleation was found to be consistent with predictions by a primary ice nucleation scheme. The other case studies had high cloud tops (&lt; −40°C) and despite no direct cloud-top measurements in these regions, homogeneous ice nucleation would be expected. The maximum ice crystal concentrations and ice water contents in all clouds were observed at temperatures around −5°C. Graupel was not observed, hence, secondary ice was produced by riming on snow falling through regions of supercooled liquid water. Within these regions substantial concentrations (10–150 L−1) of supercooled drizzle were observed. The freezing of these drops increases the riming rate due to the increase in rimer surface area. Increasing rime accretion has been shown to lead to higher ice splinter production rates. Despite differences in the cloud structure, the maximum ice crystal number concentration in all three clouds was ~100 L−1. Ice water contents were similar in the warm and occluded frontal cases, where median values in both cases reached ~0.2–0.3 g m−3, but lower in the cold front case.
Efficacy of Ethanol Ablation for Thyroglossal Duct Cyst
Authors: Lee Dong Kun , Seo Ji Won , Park Heon Soo , Kang Myung Koo , Jang Ae Lan , Lee Joon Hyung , Hong Jong Chul 
Published: July 2014

Objective: Ethanol ablation has been known as an effective, easy, and safe treatment of cystic thyroid lesions. The objective of the present study was to evaluate efficacy of ethanol ablation as a minimally invasive management of thyroglossal duct cyst (TGDC). Methods: Between January 2012 and July 2013, 9 TGDC patients were diagnosed and treated with ethanol ablation. We evaluated the treatment outcomes with the change of volume reduction and the improvement of symptomatic and cosmetic complaints and complications. Results: Initial mean tumor volume was 8.9 mL (range, 0.2-36.9 mL) in ultrasonography. The mean number of the treatment sessions was 1.7 (range, 1-3 sessions). At last follow-up, the mean volume of the treated thyroglossal duct cyst decreased significantly from 8.9 mL to 1.9 mL ( P = .019; volume reduction rate = 76.6%). Treatment success rate was 77.8% (7/9). Mean symptoms and cosmetic-grading scores improved from 5.2 to 3.1 and from 5.3 to 3.1 ( P = .062). No significant complications were observed during follow-up. Conclusion: Ethanol ablation is a feasible and convenient procedure without surgical scars and hospitalization for TGDC patients. Favorable outcomes can be achieved without significant complications.
A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)
Authors: Langdown Jonathan , Luddington Roger J. , Huntington James A. , Baglin Trevor P. 
Published: July 2014

Key PointsA novel TM mutation results in shedding of active TM into the blood. Subsequent activation of the protein C anticoagulant system causes bleeding.
Nonlinear integral inequalities on time scales with ‘maxima’
Authors: Thiramanus Phollakrit , Tariboon Jessada , Ntouyas Sotiris K 
Published: July 2014

Abstract
In this paper, some new types of nonlinear integral inequalities on time scales with ‘maxima’, which provide explicit bounds on unknown functions, are established. The importance of these integral inequalities is given by their wide applications in qualitative investigations of differential equations with ‘maxima’. An example is also presented to illustrate our results.

MSC:34A40, 26D15, 39A13.
Irremissible stimulate on ‘Unified fixed point theorems in fuzzy metric spaces via common limit range property’
Authors: Roldán-López-de-Hierro Antonio-Francisco , Karapınar Erdal , Kumam Poom 
Published: July 2014

Abstract
One of the goals of this short note is to alert researchers as regards some mistakes that appeared in a recent paper (Chauhan, Khan and Kumar in J. Inequal. Appl. 2013:182, 2013). This entails main proofs based on a false result, which invalidates all statements. We also give a complete revision of the antecedents of this work in order to find the main reasons of the mistakes. Finally, the main aim of this note is to propose a correct, more general version of the main theorems in the paper mentioned.
Solving GNOVI frameworks involving "Equation missing"-weak-GRD set-valued mappings in positive Hilbert spaces
Authors: Li Hong Gang , Pan Xian Bing , Deng Zhi Ying , Wang Chang You 
Published: July 2014

AbstractFirst, a new concept, positive Hilbert spaces, is introduced and some fundamental inequalities which are applied to studying the properties of the resolvent operator associated for(γG,λ)-weak-GRDset-valued mappings are introduced and discussed in positive Hilbert spaces. Next, by using the resolvent operator and fixed point theory, an existence theorem and an approximation algorithm to solve a new class of general nonlinear ordered inclusions are established and suggested. In this field, the results obtained seem to be general in nature.MSC:49J40, 47H06.
The hybrid steepest descent method for solutions of equilibrium problems and other problems in fixed point theory
Authors: Osilike Micha O , Ofoedu Eric U , Attah Felix U 
Published: July 2014

Abstract
In this paper, we combine the gradient projection algorithm and the hybrid steepest descent method and prove the strong convergence to a common element of the equilibrium problem; the null space of an inverse strongly monotone operator; the set of fixed points of a continuous pseudocontractive mapping and the minimizer of a convex function. This common element is proved to be the unique solution of a variational inequality problem.

MSC:47H06, 47H09, 47J05, 47J25.
Tripled common fixed point theorems under probabilistic φ-contractive conditions in generalized Menger probabilistic metric spaces
Authors: Luo Ting , Zhu Chuanxi , Wu Zhaoqi 
Published: July 2014

Abstract
In this paper, the new concepts of generalized Menger probabilistic metric spaces and tripled common fixed point for a pair of mappings

T
:
X
×
X
×
X
→
X

and

A
:
X
→
X

are introduced. Utilizing the properties of the pseudo-metric and the triangular norm, some tripled common fixed point problems of hybrid probabilistic contractions with a gauge function φ are studied. The obtained results generalize some coupled common fixed point theorems in the corresponding literature. Finally, an example is given to illustrate our main results.

MSC:47H10, 46S50.
Common fixed point theorems for generalized multivalued contractions on cone metric spaces over a non-normal solid cone
Authors: Ðorić Dragan 
Published: July 2014

Abstract
In this paper we define a new class of multivalued generalized contractions on cone metric spaces. Then, by using a necessary new technique, we prove two common fixed point theorems for a pair of those mappings on complete cone metric spaces over solid, not necessarily normal cone. Our main theorems are generalizations of the theorem of Wardowski (Appl. Math. Lett. 24:275-278, 2011) and many existing theorems in the literature. By using our main theorems, we can obtained some important corollaries which are generalizations of the well-known metric fixed point theorems to setting of cone metric spaces over a solid non-normal cone.

MSC:47H10, 54H25.
Radiologically determined orthodontically induced external apical root resorption in incisors after non-surgical orthodontic treatment of class II division 1 malocclusion: a systematic review
Authors: Tieu Long D , Saltaji Humam , Normando David , Flores-Mir Carlos 
Published: July 2014

Abstract
This study aims to critically evaluate orthodontically induced external apical root resorption (OIEARR) in incisors of patients undergoing non-surgical orthodontic treatment of class II division 1 malocclusion by a systematic review of the published data. An electronic search of two databases was performed; the bibliographies of relevant articles were also reviewed. Studies were included if they examined the amount of OIEARR in incisors produced during non-surgical orthodontic treatment of individuals with class II division I malocclusion in the permanent dentition. Individuals had no previous history of OIEARR, syndromes, pathologies, or general diseases. Study selections, risk of bias assessment, and data extraction were performed in duplicate. Eight studies of moderate methodological quality were finally included. An increased prevalence (65.6% to 98.1%) and mild to moderate severity of OIEARR (<4 mm and <1/3 original root) were reported. No sex difference in root resorption was found. For the maxillary incisors, there was no evidence that either the central or lateral incisor was more susceptible to OIEARR. A weak to moderate positive correlation between treatment duration and root resorption, and anteroposterior apical displacement and root resorption was found. Current limited evidence suggests that non-surgical comprehensive orthodontic treatment to correct class II division 1 malocclusions causes increased prevalence and severity of OIEARR the more the incisor roots are displaced and the longer this movement takes.
Phase II Randomized Trial Comparing Sequential First-Line Everolimus and Second-Line Sunitinib Versus First-Line Sunitinib and Second-Line Everolimus in Patients With Metastatic Renal Cell Carcinoma
Authors: Motzer Robert J. , Barrios Carlos H. , Kim Tae Min , Falcon Silvia , Cosgriff Thomas , Harker W. Graydon , Srimuninnimit Vichien , Pittman Ken , Sabbatini Roberto , Rha Sun Young , Flaig Thomas W. , Page Ray , Bavbek Sevil , Beck J. Thaddeus , Patel Poulam , Cheung Foon-yiu , Yadav Sunil , Schiff Edward M. , Wang Xufang , Niolat Julie , Sellami Dalila , Anak Oezlem , Knox Jennifer J. 
Published: July 2014

Purpose A multicenter, randomized phase II trial, RECORD-3, was conducted to compare first-line everolimus followed by sunitinib at progression with the standard sequence of first-line sunitinib followed by everolimus in patients with metastatic renal cell carcinoma. Patients and Methods RECORD-3 used a crossover treatment design. The primary objective was to assess progression-free survival (PFS) noninferiority of first-line everolimus compared with first-line sunitinib. Secondary end points included combined PFS for each sequence, overall survival (OS), and safety. Results Of 471 enrolled patients, 238 were randomly assigned to first-line everolimus followed by sunitinib, and 233 were randomly assigned to first-line sunitinib followed by everolimus. The primary end point was not met; the median PFS was 7.9 months for first-line everolimus and 10.7 months for first-line sunitinib (hazard ratio [HR], 1.4; 95% CI, 1.2 to 1.8). Among patients who discontinued first-line, 108 (45%) crossed over from everolimus to second-line sunitinib, and 99 (43%) crossed over from sunitinib to second-line everolimus. The median combined PFS was 21.1 months for sequential everolimus then sunitinib and was 25.8 months for sequential sunitinib then everolimus (HR, 1.3; 95% CI, 0.9 to 1.7). The median OS was 22.4 months for sequential everolimus and then sunitinib and 32.0 months for sequential sunitinib and then everolimus (HR, 1.2; 95% CI, 0.9 to 1.6). Common treatment-emergent adverse events during first-line everolimus or sunitinib were stomatitis (53% and 57%, respectively), fatigue (45% and 51%, respectively), and diarrhea (38% and 57%, respectively). Conclusion Everolimus did not demonstrate noninferiority compared with sunitinib as a first-line therapy. The trial results support the standard treatment paradigm of first-line sunitinib followed by everolimus at progression.