bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mireille's Homecoming? Gounod, Mistral, and the Midi
Authors: Ellis Katharine 
Published: September 2012

Abstract
In 1899, six years after Gounod's death, his Provençal opera Mireille (1864) suddenly became a focal point for regionalist celebration and debate in the South of France. It also, in a paradoxical sense, came “home” to Arles—a town that the original poem's author, Frédéric Mistral, made clear his heroine had never visited. In this article the resulting invented tradition, which began thirty-five years after the opera's Paris premiere and rested on standard notions of authenticity and belonging, is contextualized by reference to the very different life it led in the Midi as a standard “municipal” opera sent out, after significant revision, from Paris. Joep Leerssen's theory of cultural nationalism provides a frame for analyzing how and why this opera, which set a regionalist manifesto to music but was not a manifesto itself, could be only incompletely appropriated by Mistral and his félibres as an emblematic “national” work.
Age-Related Differences in Ruddy Turnstone Foraging and Aggressive Behavior
Authors: Groves Sarah 
Published: September 2012

Abstract
The foraging behavior of fall migrant Ruddy Turnstones was studied on the Massachusetts coast on 2 different substrates, barnacle-covered rocks and sand and weed-littered flats. Foraging rates differed significantly between the 2 substrates. On each substrate the foraging and success rates of adults and juveniles differed significantly while the frequencies of success were similar for both age-classes. The observed differences in foraging rates of adults and juveniles may be due to the degree of refinement of foraging techniques. Experience in searching for and handling prey may be a primary factor accounting for these differences, and foraging performance probably improves with age and experience. Alternatively, the differences may be due to the presence of inefficient juveniles that do not survive to adulthood.
Both adults and juveniles in the tail-depressed posture were dominant in aggressive interactions much more frequently than birds in the tail-level posture. In mixed flocks of foraging adult and juvenile turnstones, the four possible types of aggressive interactions occurred nonrandomly. Adult over juvenile interactions occurred more frequently than expected, and juvenile over adult interactions were never seen. A tentative explanation of this phenomenon may be that juveniles misinterpret or respond ambivalently to messages conveyed behaviorally by adults and thus become especially vulnerable to aggression by adults. The transiency of migrants made it unfeasible to evaluate the persistence of this nonrandom aggression.
7,7′‐Diamino‐2,2′‐diindolylmethane: A Building Block for Highly Efficient and Selective Anion Receptors—Studies in Solution and in the Solid State
Authors: Dydio Paweł , Lichosyt Dawid , Zieliński Tomasz , Jurczak Janusz 
Published: September 2012

AbstractThe easy‐to‐make 7,7′‐diamino‐2,2′‐diindolylmethane was used as a building block for the construction of anion receptors operating by hydrogen bonds. Its various bisamide and bisurea derivatives were designed and synthesised as acyclic as well as macrocyclic molecules, then their structural and anion binding properties were studied in solution and in the solid state. The bisamide receptors demonstrate high affinity towards oxoanions in highly polar and partially aqueous solutions (DMSO with up to 25 % H2O) with significant selectivity for dihydrogen phosphate. Remarkably, the bisurea‐based molecules are able to bind anionic guests even in pure methanol and show selectivity toward tetrahedral oxoanions, that is, hydrogen sulphate and dihydrogen phosphate. X‐ray analysis revealed that both classes of molecules adopt a similar conformation in the solid state: a bent sheet shape with a binding pocket equipped with hydrogen‐bond donors (four for the amides and six for the bisureas), whose orientation is particularly tailored for oxoanions. The results of ROESY NMR experiments are in agreement with the findings for the solid state and confirmed that both bisamides and bisureas can easily adapt the conformation with convergent hydrogen‐bond donors, which is highly suitable for anion binding.
In search of a surrogate for touch: The effect of haptic imagery on perceived ownership
Authors: Peck Joann , Barger Victor A. , Webb Andrea 
Published: September 2012

AbstractPrevious research has shown that individuals value objects more highly if they own them, a finding commonly known as the endowment effect. In fact, simply touching an object can create a perception of ownership that produces the endowment effect. In this paper, we extend this line of research in several ways. First, we show that haptic imagery, or imagining touching an object, can have the same effect on perceived ownership as physical touch. We then demonstrate that haptic imagery can lead to perceptions of physical control, which in turn increase feelings of ownership. Moreover, the more vivid the haptic imagery, the greater the perception of control and the feeling of ownership. Implications for theory and practice are discussed.
Bioenergy: a potential for developing countries?
Authors: Landeweerd L. , Pierce R. , Kinderlerer J. , Osseweijer P. 
Published: September 2012

Abstract
Over the past decade, sustainable development has become a pivotal element of innovation in various areas. Industrial biotechnology - through its potential to reform our energy resources - is of specific interest given its controversial reception. With the ongoing shift from a fossil-fuel-based to a bio-based economy, the demand for biomass production for biofuels and biomaterials has increased dramatically. Although countries such as the USA may have enough land-surface available, it is not likely that the necessary biomass to 'fuel' Europe can be grown domestically. Europe must look elsewhere for its biomass needs and Africa is one of the more likely candidates. A large percentage of African arable land is currently not in use for agriculture. Moreover, the production potential of developing countries near to the equator is significantly higher than that of countries in more temperate climates such as most of Europe. An increasing number of parties are showing interest in growing biomass in Africa, which may result in harm as well as benefit for these regions. Europe is not alone in turning towards equatorial regions. China for example, is a very important stakeholder currently investing in African land. Regarding the issue of competition or cooperation, the enterprise carries enormous responsibility and requires attention to be paid to a range of local and global social, economic and ethical considerations, as well as the elucidation of a clear view of what success for all parties will require from this multifaceted effort.
Evidence-based public health nutrition: what constitutes good evidence?
Authors: Knorpp L. , Kroke A. 
Published: September 2012

Abstract
The potential of dietary interventions in primary and population-based prevention has so far not been fully exploited. One explanation for the relatively sparse public health nutrition (PHN) activities might be related to a lack of rigorous methods for developing and/or selecting effective interventions. Evidence-based PHN sets out to apply existing concepts of an evidence-based approach by incorporating specific aspects from evidence-based public health and evidence-based nutrition. The aim of this review is therefore to propose an answer to the question for constituents of good evidence in PHN. To this end, existing suggestions for an evidence-based approach in PHN and the prevention paradigm of Rose are used as starting points. Complemented by a comprehensive literature search, current and new challenges in evaluating public health and nutrition interventions are summarized. This is followed by theoretical and conceptual considerations for an evidence-based approach in PHN. Structured along three core questions of why and what should be done and how should it be done, essential steps and aspects which have to be considered by decision-makers are presented. As a basic prerequisite, the need for empirical evidence from practise experiences is pointed out. In addition, it is shown that considerations of logic models and intervention theories, of economic simulations and of ethical aspects are required. Finally, a status description regarding ongoing evidence-based activities in PHN is given.
Consequences of phosphoenolpyruvate:sugar phosphotranferase system and pyruvate kinase isozymes inactivation in central carbon metabolism flux distribution in Escherichia coli
Authors: Meza Eugenio , Becker Judith , Bolivar Francisco , Gosset Guillermo , Wittmann Christoph 
Published: September 2012

Abstract

Background
In Escherichia coli phosphoenolpyruvate (PEP) is a key central metabolism intermediate that participates in glucose transport, as precursor in several biosynthetic pathways and it is involved in allosteric regulation of glycolytic enzymes. In this work we generated W3110 derivative strains that lack the main PEP consumers PEP:sugar phosphotransferase system (PTS-) and pyruvate kinase isozymes PykA and PykF (PTS-
pykA
- and PTS-
pykF
-). To characterize the effects of these modifications on cell physiology, carbon flux distribution and aromatics production capacity were determined.

Results
When compared to reference strain W3110, strain VH33 (PTS-) displayed lower specific rates for growth, glucose consumption and acetate production as well as a higher biomass yield from glucose. These phenotypic effects were even more pronounced by the additional inactivation of PykA or PykF. Carbon flux analysis revealed that PTS inactivation causes a redirection of metabolic flux towards biomass formation. A cycle involving PEP carboxylase (Ppc) and PEP carboxykinase (Pck) was detected in all strains. In strains W3110, VH33 (PTS-) and VH35 (PTS-, pykF
-), the net flux in this cycle was inversely correlated with the specific rate of glucose consumption and inactivation of Pck in these strains caused a reduction in growth rate. In the PTS- background, inactivation of PykA caused a reduction in Ppc and Pck cycling as well as a reduction in flux to TCA, whereas inactivation of PykF caused an increase in anaplerotic flux from PEP to OAA and an increased flux to TCA. The wild-type and mutant strains were modified to overproduce L-phenylalanine. In resting cells experiments, compared to reference strain, a 10, 4 and 7-fold higher aromatics yields from glucose were observed as consequence of PTS, PTS PykA and PTS PykF inactivation.

Conclusions
Metabolic flux analysis performed on strains lacking the main activities generating pyruvate from PEP revealed the high degree of flexibility to perturbations of the central metabolic network in E. coli. The observed responses to reduced glucose uptake and PEP to pyruvate rate of conversion caused by PTS, PykA and PykF inactivation included flux rerouting in several central metabolism nodes towards anabolic biosynthetic reactions, thus compensating for carbon limitation in these mutant strains. The detected cycle involving Ppc and Pck was found to be required for maintaining the specific growth and glucose consumption rates in all studied strains. Strains VH33 (PTS-), VH34 (PTS-
pykA
-) and VH35 (PTS-
pykF
-) have useful properties for biotechnological processes, such as increased PEP availability and high biomass yields from glucose, making them useful for the production of aromatic compounds or recombinant proteins.
The Relationship between Egg Size and Chick Size in the Laughing Gull and Japanese Quail
Authors: Ricklefs Robert E. , Hahn D. Caldwell , Montevecchi William A. 
Published: September 2012

AbstractVariation in the water, lipid, and nonlipid dry matter of eggs and newly hatched chicks of the Laughing Gull and Japanese Quail was related to variation in the size of the egg. Egg contents of the two species were, on average, very similar. Yolk size varied in direct proportion to egg size, but in the quail large eggs contained disproportionately low levels of lipid and high levels of nonlipid dry matter.The composition of the newly hatched gull chick closely resembled that of the newly hatched quail. With increasing egg size, and thus chick size, water level increased and lipid level decreased in the gull chick, whereas lipid level increased in the quail chick. Among body organs, the integument of the gull exhibited a disproportionate increase with an increase in egg size, owing mostly to the accumulation of water; in the quail, the legs were the only organs to increase out of proportion to increase in body size. Disproportionate decreases in body proportion with increasing chick size appeared mostly in the head, stomach, and intestine components of both species.Variation in proportions of lipid and water in the chick related to egg size is discussed in terms of (1) ecological requirements of newly hatched chicks, (2) sibling competition within broods, and (3) stage of development of the young at hatching.
On the Adaptive Value of Intraclutch Egg-Size Variation in Birds
Authors: Slagsvold Tore , Sandvik Jostein , Rofstad Gunnar , Lorentsen Öystein , Husby Magne 
Published: September 2012

AbstractUsing data from the field and the literature on 67 species of birds, we analyzed intraclutch variation in egg size, especially the deviation of the last egg from the clutch mean (D). Values of D are closer to zero in precocial than in altricial species; D is negatively correlated with body size in interspecific comparisons, i.e. large birds, including precocial species, lay small final eggs; and D is higher in open-nesting passerines (on average D = +3.56%, 17 species) than in hole-nesting species (on average D = -0.05%, 13 species). Within populations of birds, a negative relationship exists between D and clutch size, particularly in species that have a generally low value of D. The results support the view that intraclutch variation in egg size has an ultimate, adaptive value. We suggest that birds adopting the "brood-reduction strategy" have a small final egg, particularly those birds with large clutches, whereas birds adopting the "brood-survival strategy" have a relatively large final egg, particularly those birds with large clutches.
Estimation by Use of Field Weighings of Metabolic Rate and Food Conversion Efficiency in Albatross Chicks
Authors: Ricketts C. , Prince P. A. 
Published: September 2012

Abstract
A knowledge of the assimilation of food and of the energetic demands of chicks at different stages in the growth period can provide a basis for understanding growth strategies of seabirds. We have developed a simple model of chick weight loss between feeds that allows an estimation of metabolic costs and food-conversion efficiency in albatross chicks. The data required to provide these estimates are a series of frequent weights of a chick following a meal and the weight of food delivered in the meal. Preliminary results show a considerable variation in both food-conversion efficiency, which may reflect variation in the composition of meals delivered to chicks, and in the metabolic demands of individual chicks.
The Effects of Adult Fecal Material on Egg Hatchability in Glaucous-Winged Gulls (Larus glaucescens)
Authors: Verbeek Nicolaas A. M. 
Published: September 2012

Abstract
The effect of gull and cormorant feces applied to naturally incubated Glaucous-winged Gull eggs upon hatching success was studied on Mandarte Island, British Columbia. Gull feces, but not cormorant feces, significantly reduced the hatching success of treated eggs below that of control eggs. Eggs treated with gull feces lost significantly less water during incubation than either control eggs or eggs treated with cormorant feces. Eggs that were covered with gull feces but that nevertheless hatched had a significantly longer incubation period than did control eggs. The removal of the fat from the feces with ether before application to the eggs did not significantly improve hatching success.
Effects of Caffeine on Metabolism and Mitochondria Biogenesis in Rhabdomyosarcoma Cells Compared with 2,4-Dinitrophenol
Authors: Vaughan Roger A. , Garcia-Smith Randi , Bisoffi Marco , Trujillo Kristina A. , Conn Carole A. 
Published: September 2012

Purpose This work investigated if treatment with caffeine or 2,4-dinitrophenol (DNP) induce expression of peroxisome proliferator-activated receptor coactivator 1 alpha (PGC-1α) and increase both mitochondrial biosynthesis and metabolism in skeletal muscle. Methods Human rhabdomyosarcoma cells were treated with either ethanol control (0.1% final concentration) caffeine, or DNP at 250 or 500 μM for 16 or 24 hours. PGC-1α RNA levels were determined using quantitative reverse transcriptase polymerase chain reaction (qRT-PCR). PGC-1α protein and mitochondrial content was determined using flow cytometry and immunohistochemistry. Metabolism was determined by quantification of extracellular acidification rate and oxygen consumption rate. Results Treatment with either caffeine or DNP induced PGC-1α RNA and protein as well as mitochondrial content compared with control. Treatment with caffeine and DNP also significantly increased oxidative metabolism and total metabolic rate compared with control. Caffeine similarly increased metabolism and mitochondrial content compared with DNP. Conclusion This work identified that both caffeine and DNP significantly induce PGC-1α, and increase both metabolism and mitochondrial content in skeletal muscle.
Effects of Heat Treatment on Raman Spectra of Two‐Layer 12C/13C Graphene
Authors: Kalbac Martin , Frank Otakar , Kavan Ladislav 
Published: September 2012

AbstractThe Raman spectra of two‐layered graphene on a silicon substrate were studied in the temperature range from 298 to 1073 K in an inert atmosphere. Isotopic engineering was used to fabricate two‐layer graphene specimens containing 13C atoms in the top layer and 12C atoms in the bottom layer, which allowed the behavior of each particular layer to be distinguished as a function of temperature. It is demonstrated that the top layer exhibits much lower Raman temperature coefficients than the bottom one for both the G and the G′ modes. We suggest that the changes in the Raman spectra of graphene observed during thermal cycling are predominantly caused by a superposition of two effects, namely, the mechanical stress in graphene exerted by the substrate and the intrinsic changes in the graphene lattice caused by the temperature itself. The top graphene layer is proposed to be more relaxed than the bottom graphene layer and thus reflects almost exclusively the temperature variations as a freestanding graphene layer would.
(R)‐α‐Lipoyl‐Glycyl‐L‐Prolyl‐L‐Glutamyl Dimethyl Ester Codrug as a Multifunctional Agent with Potential Neuroprotective Activities
Authors: Cacciatore Ivana , Baldassarre Leonardo , Fornasari Erika , Cornacchia Catia , Di Stefano Antonio , Sozio Piera , Cerasa Laura Serafina , Fontana Antonella , Fulle Stefania , Di Filippo Ester Sara , La Rovere Rita Maria Laura , Pinnen Francesco 
Published: September 2012

AbstractThe (R)‐α‐lipoyl‐glycyl‐L‐prolyl‐L‐glutamyl dimethyl ester codrug (LA‐GPE, 1) was synthesized as a new multifunctional drug candidate with antioxidant and neuroprotective properties for the treatment of neurodegenerative diseases. Physicochemical properties, chemical and enzymatic stabilities were evaluated, along with the capacity of LA‐GPE to penetrate the blood–brain barrier (BBB) according to an in vitro parallel artificial membrane permeability assay for the BBB. We also investigated the potential effectiveness of LA‐GPE against the cytotoxicity induced by 6‐hydroxydopamine (6‐OHDA) and H2O2 on the human neuroblastoma cell line SH‐SY5Y by using the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium bromide (MTT) reduction assay. Our results show that codrug 1 is stable at both pH 1.3 and 7.4, exhibits good lipophilicity (log P=1.51) and a pH‐dependent permeability profile. Furthermore, LA‐GPE was demonstrated to be significantly neuroprotective and to act as an antioxidant against H2O2‐ and 6‐OHDA‐induced neurotoxicity in SH‐SY5Y cells.
Four‐dimensional velocity‐encoded magnetic resonance imaging improves blood flow quantification in patients with complex accelerated flow
Authors: Nordmeyer Sarah , Riesenkampff Eugénie , Messroghli Daniel , Kropf Siegfried , Nordmeyer Johannes , Berger Felix , Kuehne Titus 
Published: September 2012

AbstractPurpose:To evaluate the use of four‐dimensional (4D) velocity‐encoded magnetic resonance imaging (VEC MRI) for blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow.Materials and Methods:Peak velocities (Vmax) and stroke volumes (SV) were quantified by 2D and 4D VEC MRI in volunteers (n = 7) and patients with semilunar valve stenosis (n = 18). Measurements were performed above the aortic and pulmonary valve with both techniques and, additionally, at multiple predefined planes in the ascending aorta and in the pulmonary trunk within the 4D dataset. In patients, 4D VEC MRI streamline analysis identified flow patterns and regions of highest flow velocity (4Dmax‐targeted) for further measurements and Vmax was also measured by Doppler‐echocardiography.Results:In patients, 4D VEC MRI showed higher Vmax than 2D VEC MRI (2.7 ± 0.6 m/s vs. 2.4 ± 0.5 m/s, P < 0.03) and was more comparable to Doppler‐echocardiography (2.8 ± 0.7 m/s). 4Dmax‐targeted revealed highest Vmax values (3.1 ± 0.6 m/s). SV measurements showed significant differences between different anatomical levels in the ascending aorta in patients with complex accelerated flow, whereas differences in volunteers with laminar flow patterns were negligible (P = 0.004).Conclusion:4D VEC MRI improves MRI‐derived blood flow quantification in patients with semilunar valve stenosis and complex accelerated flow. J. Magn. Reson. Imaging 2013;37:208–216. © 2012 Wiley Periodicals, Inc.
High-affinity and -specificity, bacteriophage-based technologies: beyond phage therapy - Mini Review.
Authors: Hyman P. , Abedon S. T. 
Published: September 2012

Abstract
Taking advantage of bacteriophage versatility and potential to have little negative impact on human health, several medically oriented, phage-based technologies have been developed in addition to phage therapy. Here, we emphasize bacteriophage capacities for natural and enhanced high-specificity binding in phage display, bacterial detection, bacterial identification and nanotechnology.
Cardiac autonomic dysregulation in acute schizophrenia
Authors: Chang Hsin-An , Chang Chuan-Chia , Tzeng Nian-Sheng , Kuo Terry B. J. , Lu Ru-Band , Huang San-Yuan 
Published: September 2012

ObjectiveAltered cardiac autonomic function has been proposed in schizophrenia, but the results are mixed. Therefore, analyses with larger sample sizes and better methodology are needed.MethodsTo examine whether acute schizophrenia is associated with cardiac autonomic dysfunction, 314 unmedicated patients with acute schizophrenia and 409 healthy volunteers, aged 18–65 years, were recruited for a case–control analysis. The severity of schizophrenia symptoms was assessed with the Positive and Negative Syndrome Scale. Cardiac autonomic function was evaluated by measuring heart rate variability (HRV) parameters during the supine–standing–supine test. Frequency-domain indices of HRV were obtained.ResultsUnmedicated patients with acute schizophrenia consistently exhibited reduced mean RR interval and HRV levels in a supine rest and standing position compared with healthy volunteers. The severity of psychopathology, in particular positive symptoms, was negatively correlated with cardiac vagal control.ConclusionThese data suggest that acute schizophrenia is accompanied by cardiac autonomic dysregulation. In view of the higher risk for cardiac complications in these patients, one might also consider the antipsychotic treatment in favour of improving cardiac autonomic modulation. Further studies using larger patient groups and controlled therapeutics may better understand the influence of antipsychotic treatment on cardiac autonomic regulation in schizophrenia.