bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Analysis of Antibodies against Dengue Virus Type 4 Reveals Strain-Dependent Epitope Exposure That Impacts Neutralization and Protection
Authors: Sukupolvi-Petty Soila , Brien James D. , Austin S. Kyle , Shrestha Bimmi , Swayne Sherri , Kahle Kristen , Doranz Benjamin J. , Johnson Syd , Pierson Theodore C. , Fremont Daved H. , Diamond Michael S. 
Published: June 2013

ABSTRACTAlthough prior studies have characterized the neutralizing activities of monoclonal antibodies (MAbs) against dengue virus (DENV) serotypes 1, 2, and 3 (DENV-1, DENV-2, and DENV-3), few reports have assessed the activity of MAbs against DENV-4. Here, we evaluated the inhibitory activity of 81 new mouse anti-DENV-4 MAbs. We observed strain- and genotype-dependent differences in neutralization of DENV-4 by MAbs mapping to epitopes on domain II (DII) and DIII of the envelope (E) protein. Several anti-DENV-4 MAbs inefficiently inhibited at least one strain and/or genotype, suggesting that the exposure or sequence of neutralizing epitopes varies within isolates of this serotype. Remarkably, flavivirus cross-reactive MAbs, which bound to the highly conserved fusion loop in DII and inhibited infection of DENV-1, DENV-2, and DENV-3, more weakly neutralized five different DENV-4 strains encompassing the genetic diversity of the serotype after preincubation at 37°C. However, increasing the time of preincubation at 37°C or raising the temperature to 40°C enhanced the potency of DII fusion loop-specific MAbs and some DIII-specific MAbs against DENV-4 strains. Prophylaxis studies in two new DENV-4 mouse models showed that neutralization titers of MAbs after preincubation at 37°C correlated with activityin vivo. Our studies establish the complexity of MAb recognition against DENV-4 and suggest that differences in epitope exposure relative to other DENV serotypes affect antibody neutralization and protective activity.
DNA Hypomethylation, Ambient Particulate Matter, and Increased Blood Pressure: Findings From Controlled Human Exposure Experiments
Authors: Bellavia Andrea , Urch Bruce , Speck Mary , Brook Robert D. , Scott Jeremy A. , Albetti Benedetta , Behbod Behrooz , North Michelle , Valeri Linda , Bertazzi Pier Alberto , Silverman Frances , Gold Diane , A. Baccarelli Andrea 
Published: June 2013

Background

Short‐term exposures to fine (<2.5 μm aerodynamic diameter) ambient particulate‐matter (
PM
) have been related with increased blood pressure (
BP
) in controlled‐human exposure and community‐based studies. However, whether coarse (2.5 to 10 μm)
PM
exposure increases
BP
is uncertain. Recent observational studies have linked
PM
exposures with blood
DNA
hypomethylation, an epigenetic alteration that activates inflammatory and vascular responses. No experimental evidence is available to confirm those observational data and demonstrate the relations between
PM
, hypomethylation, and
BP
.

Methods and Results

We conducted a cross‐over trial of controlled‐human exposure to concentrated ambient particles (
CAP
s). Fifteen healthy adult participants were exposed for 130 minutes to fine
CAP
s, coarse
CAP
s, or
HEPA
‐filtered medical air (control) in randomized order with ≥2‐week washout. Repetitive‐element (

Alu

, long interspersed nuclear element‐1 [
LINE
‐1]) and candidate‐gene (

TLR4

,

IL‐12

,

IL‐6

,

iNOS

) blood methylation, systolic and diastolic
BP
were measured pre‐ and postexposure. After adjustment for multiple comparisons, fine
CAP
s exposure lowered

Alu

methylation (β‐standardized=−0.74, adjusted‐
P
=0.03); coarse
CAP
s exposure lowered

TLR4

methylation (β‐standardized=−0.27, adjusted‐
P
=0.04). Both fine and coarse
CAP
s determined significantly increased systolic
BP
(β=2.53 mm Hg,
P
=0.001; β=1.56 mm Hg,
P
=0.03, respectively) and nonsignificantly increased diastolic
BP
(β=0.98 mm Hg,
P
=0.12; β=0.82 mm Hg,
P
=0.11, respectively). Decreased

Alu

and

TLR4

methylation was associated with higher postexposure
DBP
(β‐standardized=0.41,
P
=0.04; and β‐standardized=0.84,
P
=0.02; respectively). Decreased

TLR4

methylation was associated with higher postexposure
SBP
(β‐standardized=1.45,
P
=0.01).

Conclusions

Our findings provide novel evidence of effects of coarse
PM
on
BP
and confirm effects of fine
PM
. Our results provide the first experimental evidence of
PM
‐induced
DNA
hypomethylation and its correlation to
BP
.
Objective Art
Authors: Lapin Leonhard 
Published: June 2013

Abstract
Leonhard Lapin's “Objective Art” was written for “Event Harku '75. Objects, Concepts” – an exhibtion and an accompanying symposium on the premises of the Institute of Experimental Biology in Harku, near Tallinn, Estonia, in December 1975. Objective art, in the artist's mind, answered to the industrialization and urbanization of the late 20th century, to the growing significance of not only mechanical but also electronic machines in everyday life, and to the emergence of the so-called artificial environment. Rather than representing this environment, new art had to intervene in it or even produce it. Lapin's call was quite different from other reactions to the changing postindustrial environment in the mid 1970s in the Soviet Union in that instead of active intervention many of them proposed withdrawal as the most appropriate tactics to resist the grim surrounding reality.
Inflammatory myofibroblastic tumor of the temporal bone presenting with pulsatile tinnitus: a case report
Authors: Zhou Xiaoli , Liu Tingting , Chen Zhibin , Zhang Zhihong , Xing Guangqian 
Published: June 2013

Abstract

Introduction
Inflammatory myofibroblastic tumor of the temporal bone is an unusual but distinct disease entity. The most common presenting symptoms are otalgia, otorrhea, hearing loss, facial palsy, and vertigo. We describe here what we believe to be the first reported case of a patient presenting with persistent pulsatile tinnitus. The clinical features, radiological and histopathologic findings, and treatment outcomes of the patient are presented.

Case presentation
A 59-year-old woman of Chinese Han origin presented with complaints of left-sided pulsatile tinnitus and progressive hearing loss for several years. Clinical evaluations revealed a reddish mass behind the intact tympanic membrane, and a moderately severe conductive hearing loss in the left ear. The computed tomographic imaging of the temporal bone demonstrated a slightly ill-defined left middle ear soft tissue mass involving the posterior portion of the mesotympanum and epitympanum, and the mastoid antrum. The patient underwent surgical excision of the lesion which subsequently resolved her symptoms. Postoperative pathology was consistent with an inflammatory myofibroblastic tumor.

Conclusions
An inflammatory myofibroblastic tumor of the temporal bone can present clinically with pulsatile tinnitus and masquerade as venous hum or vascular tumors of the middle ear; therefore, it should be included in the differential diagnosis of pulsatile tinnitus.
Role of centrosomal adaptor proteins of the TACC family in the regulation of microtubule dynamics during mitotic cell division
Authors: Thakur Harish C. , Singh Madhurendra , Nagel-Steger Luitgard , Prumbaum Daniel , Fansa Eyad Kalawy , Gremer Lothar , Ezzahoini Hakima , Abts André , Schmitt Lutz , Raunser Stefan , Ahmadian Mohammad R. , Piekorz Roland P. 
Published: June 2013

Abstract
During the mitotic division cycle, cells pass through an extensive microtubule rearrangement process where microtubules forming the mitotic spindle apparatus are dynamically instable. Several centrosomal- and microtubule-associated proteins are involved in the regulation of microtubule dynamics and stability during mitosis. Here, we focus on members of the transforming acidic coiled coil (TACC) family of centrosomal adaptor proteins, in particular TACC3, in which their subcellular localization at the mitotic spindle apparatus is controlled by Aurora-A kinase-mediated phosphorylation. At the effector level, several TACC-binding partners have been identified and characterized in greater detail, in particular, the microtubule polymerase XMAP215/ch-TOG/CKAP5 and clathrin heavy chain (CHC). We summarize the recent progress in the molecular understanding of these TACC3 protein complexes, which are crucial for proper mitotic spindle assembly and dynamics to prevent faulty cell division and aneuploidy. In this regard, the (patho)biological role of TACC3 in development and cancer will be discussed.
Sebészi kockázat májbetegeken
Authors: Jakab Ferenc 
Published: June 2013

AbsztraktA szerző a betegbiztonság követelményeiből kiindulva a kockázatanalízis fontosságára hívja fel a figyelmet. Megállapítja, hogy a minőségi követelmények növekedése nem hagyta érintetlenül a sebészetet sem, és ezért ma már konkrét fogalmaink vannak a sebészi kockázat meghatározására és értékelésére. Ez a folyamat az elmúlt évtizedekben a mind gyakrabban indikált és mind szélesebb körben végzett, növekvő számú májműtétek halálozásának jelentős csökkenésében is nyomon követhető. Különös fontossága van a műtétek kockázatának májbetegeken. A feltétlen vagy abszolút ellenjavallatok jól körülhatárolhatók. A májbetegeken tervezett májműtétetek kockázata számszerűen is kifejezhető. A régóta használt Child–Turcotte–Pugh-stádiumai számértékek alapján határozhatók meg. Újabban az „50–50-es” szabály, illetve a májtranszplantációs gyakorlatból átvett MELD érték kiszámítása jelent a sebésznek objektív fogódzót a mindennapos munkájában. A szerző kitér a kockázatanalízis alapján választható kezelési optimalizációra is, amely a májsebészek igényei alapján multidiszciplináris megközelítésben valósulhat meg.
Periodontal Disease as a Risk Factor for Bisphosphonate‐Related Osteonecrosis of the Jaw
Authors: Thumbigere‐Math Vivek , Michalowicz Bryan S. , Hodges James S. , Tsai Michaela L. , Swenson Karen K. , Rockwell Laura , Gopalakrishnan Rajaram 
Published: June 2013

Background: Previous case reports and animal studies suggest that periodontitis is associated with bisphosphonate‐related osteonecrosis of the jaw (BRONJ). This case‐control study is conducted to evaluate the association between clinical and radiographic measures of periodontal disease and BRONJ.Methods: Twenty‐five patients with BRONJ were matched with 48 controls. Trained examiners measured probing depth, clinical attachment level (CAL), and bleeding on probing on all teeth except third molars and gingival and plaque indices on six index teeth. Alveolar bone height was measured from orthopantomograms. Most patients with BRONJ were using antibiotics (48%) or a chlorhexidine mouthrinse (84%) at enrollment. Adjusted comparisons of patients with BRONJ versus controls used multiple linear regression.Results: The average number of bisphosphonate (BP) infusions was significantly higher in patients with BRONJ compared with controls (38.4 versus 18.8, P = 0.0001). In unadjusted analyses, patients with BRONJ had more missing teeth (7.8 versus 3.1, P = 0.002) and higher average CAL (2.18 versus 1.56 mm, P = 0.047) and percentage of sites with CAL ≥3 mm (39.0 versus 23.3, P = 0.039) than controls. Also, patients with BRONJ had lower average bone height (as a fraction of tooth length, 0.59 versus 0.62, P = 0.004) and more teeth with bone height less than half of tooth length (20% versus 6%, P = 0.001). These differences remained significant after adjusting for age, sex, smoking, and number of BP infusions.Conclusions: BRONJ patients have fewer teeth, greater CAL, and less alveolar bone support compared with controls after adjusting for number of BP infusions. Group differences in antibiotics and chlorhexidine rinse usage may have masked differences in the other clinical measures.
Proton Conduction in Dense and Porous Nanocrystalline Ceria Thin Films
Authors: Gregori Giuliano , Shirpour Mona , Maier Joachim 
Published: June 2013

AbstractThe electrical conductivity of ceria thin films (epitaxial as well as dense and porous nanocrystalline) is investigated in dry and wet atmosphere at temperatures below 500 °C. For the epitaxial and the fully dense nanocrystalline samples, no significant differences can be observed between dry and wet conditions. In marked contrast, the nanocrystalline porous films obtained via spin coating exhibit a considerable enhancement of the protonic conductivity below 300 °C in wet atmosphere. This outcome reveals that the residual open mesoporosity plays the key role for the enhancement of the proton transport at low temperatures and not the high density of grain boundaries. The quantitative analysis of the various pathways, along which the proton transport can take place, indicates that the observed proton conduction can arise not only from bulk water adsorbed in the open pores but also from the space charge zones on the water side of the water/oxide interface.
Quaternary Diamond‐Like Chalcogenidometalate Networks as Efficient Anode Material in Lithium‐Ion Batteries
Authors: Kaib Thomas , Haddadpour Sima , Andersen Hanne Flåten , Mayrhofer Leonhard , Järvi Tommi T. , Moseler Michael , Möller Kai‐Christian , Dehnen Stefanie 
Published: June 2013

AbstractAn improvement of lithium‐ion batteries with regard to their reversible capacity, cycling stability, rate performance, and safety under repetitive charge and discharge still requires considerable research activity. However, graphite has remained the unexcelled material for the anode so far. Here, it is shown that two novel quaternary lithium‐chalcogenidometalate phases, Li4MnGe2S7 (1) and Li4MnSn2Se7 (2), represent very promising new anode materials for lithium‐ion cells in that they achieve specific lithium storage capacities higher than that of the commercially used graphite, and display an excellent stability during cycling. These properties are based on the structural peculiarities of the phases, which adopt Wurtzite‐related topologies and provide high structural flexibility of the metal sulfide or selenide bonds as advantageous pre‐requisitions for a large ion accessible volume.
Waldenström macroglobulinemia: 2013 update on diagnosis, risk stratification, and management
Authors: Gertz Morie A. 
Published: June 2013

Disease OverviewWaldenström macroglobulinemia (WM) is a lymphoplasmacytic lymphoma with immunoglobulin M (IgM) monoclonal protein. Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, and lymphadenopathy.DiagnosisThe presence of IgM monoclonal protein associated with ≥10% clonal lymphoplasmacytic cells in bone marrow confirms the diagnosis.Risk StratificationAge, hemoglobin level, platelet count, β2 microglobulin, and monoclonal IgM concentrations are characteristics required for prognosis.Risk‐Adapted TherapyNot all patients who fulfill WM criteria require therapy; these patients can be observed until symptoms develop. Rituximab‐based therapy is used in virtually all US patients with WM and can be combined with alkylating agent or purine nucleoside analog (or both). The preferred Mayo Clinic nonstudy therapeutic induction is rituximab, cyclophosphamide, and dexamethasone. Future stem cell transplantation should be considered in induction therapy selection.Management of Refractory DiseaseBortezomib, thalidomide, everolimus, lenalidomide, and bendamustine have all been shown to have activity in WM. Given WM's natural history, reduction of complications will be a priority for future treatment trials. Am. J. Hematol. 88:703–711, 2013. © 2013 Wiley Periodicals, Inc.
Characteristics and magnitude of acute pesticide‐related illnesses and injuries associated with pyrethrin and pyrethroid exposures—11 states, 2000–2008
Authors: Hudson Naomi L. , Kasner Edward J. , Beckman John , Mehler Louise , Schwartz Abby , Higgins Sheila , Bonnar‐Prado Joanne , Lackovic Michelle , Mulay Prakash , Mitchell Yvette , Larios Leo , Walker Rob , Waltz Justin , Moraga‐McHaley Stephanie , Roisman Rachel , Calvert Geoffrey M. 
Published: June 2013

AbstractBackgroundExcluding disinfectants, pyrethrins and pyrethroids are the pesticides used most commonly in and around homes. Respiratory effects and paresthesia are among the concerns about pyrethrin/pyrethroid exposures.MethodsAcute pesticide‐related illness/injury cases were identified from the Sentinel Event Notification System for Occupational Risks‐Pesticides Program and the California Department of Pesticide Regulation from 2000–2008. Characteristics and incidence rates were determined for acute pyrethrin/pyrethroid‐related illness/injury cases. Logistic regression analyses were performed to determine odds of respiratory and dermal symptoms in persons with illness/injury following pyrethrin/pyrethroid exposure compared to persons with illness/injury following exposure to other pesticides.ResultsA total of 4,974 cases of acute pyrethrin/pyrethroid‐related illness were identified. Incidence rates increased over time, reaching 8 cases/million population in 2008. The majority of cases were low severity (85%) and 34% were work‐related. Respiratory effects were the most common symptoms reported (48%). Risk of acute respiratory effects were significantly elevated among persons exposed only to pyrethrins (adjusted odds ratio [aOR] 1.79; 95% confidence interval [95% CI]: 1.49–2.16), only to pyrethroids (aOR 1.99 95% CI: 1.77–2.24), to a mixture of pyrethroids (aOR 2.36; 95% CI: 1.99–2.81) or to a mixture containing both pyrethrins and pyrethroids (aOR 2.99; 95% CI: 2.33–3.84) compared to those with illness arising from exposure to other pesticides. The most common factors contributing to pyrethrin/pyrethroid‐related illness included exposure from spills/splashes, improper storage, and failure to evacuate during pesticide application.ConclusionsThe magnitude of acute pyrethrin/pyrethroid‐related illness/injury is relatively low but is increasing. As such, additional measures to prevent them are needed. Am. J. Ind. Med. 57:15–30, 2014. © 2013 Wiley Periodicals, Inc.
Cyanine‐Like Dyes with Large Bond‐Length Alternation
Authors: Thorley Karl J. , Hales Joel M. , Kim Hyeongeu , Ohira Shino , Brédas Jean‐Luc , Perry Joseph W. , Anderson Harry L. 
Published: June 2013

AbstractHerein, the synthesis and properties of alkyne‐bridged carbocations, which are analogous in structure to cyanine dyes, are reported. An alkene‐bridged dye, linked at the third position of the indole, was also synthesized as a reference compound. These new carbocations are stable under ambient conditions, allowing characterization by UV/Vis and NMR (1H and 13C) spectroscopies. These techniques revealed a large degree of delocalization of the positive charge, similar to a previously reported porphyrin carbocation. The linear and nonlinear optical properties are compared with cyanine dyes and triarylmethyl cations, to investigate the effects of the bond‐length alternation and the overall molecular geometry. The value of Re(γ), the real part of the third‐order microscopic polarizability, of −1.3×10−33 esu for the alkyne‐linked cation is comparable to that of a cyanine dye of similar length. Nondegenerate two‐photon absorption spectra showed that the alkene‐bridged dye exhibited characteristics of cyanines, whereas the alkyne‐bridged dye is reminiscent of octupolar chromophores, such as the triarylmethyl carbocation brilliant green. Such attributes were confirmed and rationalized by quantum chemical calculations.
Differential Cadherin Expression in the Developing Postnatal Telencephalon of a New World Monkey
Authors: Matsunaga Eiji , Nambu Sanae , Oka Mariko , Iriki Atsushi 
Published: June 2013

ABSTRACTCadherins are cell adhesion molecules widely expressed in the nervous system, where they play various roles in neural patterning, nuclei formation, axon guidance, and synapse formation and function. Although many published articles have reported on cadherin expression in rodents and ferrets, there are limited data on their expression in primate brains. In this study, in situ hybridization analysis was performed for 10 cadherins [nine classic cadherins (Cdh4, ‐6, ‐7, ‐8, ‐9, ‐10, ‐11, ‐12, and ‐20) and T‐cadherin (Cdh13)] in the developing postnatal telencephalon of the common marmoset (Callithrix jacchus). Each cadherin showed broad expression in the cerebral cortex, basal ganglia, amygdala, and hippocampus, as previously shown in the rodent brain. However, detailed expression patterns differed between rodents and marmosets. In contrast to rodents, cadherin expression was reduced overall and localized to restricted areas of the brain during the developmental process, suggesting that cadherins are more crucially involved in developmental or maturation processes rather than in neural functioning. These results also highlight the possibility that restricted/less redundant cadherin expression allows primate brains to generate functional diversity among neurons, allowing morphological and functional differences between rodents and primates. J. Comp. Neurol. 521:4027–4060, 2013. © 2013 Wiley Periodicals, Inc.
Development of a Simplified Calculation Tool for Voltage Drop Caused by Transformer Inrush in Distribution System
Authors: Nakachi Yoshiki , Fukae Takayuki , Sugahara Toshinori , Nakamura Hayato , Koyama Mitsuaki , Ueda Fukashi 
Published: June 2013

SummaryIt is well known that a voltage drop due to inrush current at an energizing transformer may at times interrupt electrical equipment. Generally, the voltage drop is calculated by using a sophisticated tool such as EMTP, so that the transformer saturation phenomenon has been properly represented. However, it is not practical for distribution system engineers to calculate the voltage drop with transformer inrush by using EMTP, because there are many network access requests needing such calculations with many kinds of transformers. Therefore, in this paper, a simplified and easy‐to‐use calculation tool for voltage drops caused by transformer inrush in a distribution system is developed. In order to understand the voltage drop by inrush current during the planning stage, it is formulated by considering the transformer saturation/unsaturation periods in each winding type. The newly developed tool is based on versatile spreadsheet software such as Microsoft Excel ýO.R. It can be used with accuracy similar to that of EMTP. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 185(1): 36–47, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22394
A Method for Reducing Grounding Impedance
Authors: Fujita Yuta , Morii Hiroshi , Kubo Takashi 
Published: June 2013

SummaryThis paper investigates grounding impedance reduction with various shapes of grounding electrodes in comparison with a conventional vertical rod based on field measurements and FDTD simulations. It is found that a vertical rectangular conducting plate is effective for reducing the transient and steady‐state impedance to less than half that of the vertical rod. A circular conducting plate parallel to the earth surface is also effective in reducing the steady‐state impedance, but the transient impedance is nearly the same as that of the vertical rod. The rate of reduction is proportional in some way to the surface area of the electrode, but tends to saturate as the area increases. The transient impedance is rather independent of the earth resistivity and permittivity, but tends to be inversely proportional to the wavefront duration of the applied current. © 2013 Wiley Periodicals, Inc. Electr Eng Jpn, 185(1): 27–35, 2013; Published online in Wiley Online Library (wileyonlinelibrary.com). DOI 10.1002/eej.22405