bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sleep quality in middle-aged and elderly hemodialysis patients: Impact of a structured nursing intervention program
Authors: Tao Ling-Ling , Zeng Cai-Hua , Mei Wen-Juan , Zou Yan-Li 
Published: July 2024

BACKGROUND
Poor sleep quality is common among hemodialysis patients and can significantly impact their well-being. This study aimed to evaluate the effectiveness of a structured nursing intervention program in improving sleep quality in middle-aged and elderly hemodialysis patients.
AIM
To evaluate the impact of nursing intervention on sleep quality in hemodialysis patients.
METHODS
This cross-sectional study was conducted in a tertiary hospital, the First Affiliated Hospital of Nanchang University, in 2023. This study included 105 middle-aged and elderly hemodialysis patients aged ≥ 45 years who underwent maintenance hemodialysis for at least 3 mo, utilizing the Pittsburgh Sleep Quality Index (PSQI) to identify poor sleepers. Those identified underwent a 12-wk nursing intervention program focusing on education, relaxation techniques, and counseling. Post-intervention, sleep quality was reassessed using the PSQI.
RESULTS
The study found that 68.6% of hemodialysis patients were poor sleepers. Following the 12-wk nursing intervention program, there was a significant decrease in the mean global PSQI score from 8.9 ± 3.2 to 5.1 ± 2.7 (P < 0.001), indicating improved sleep quality. This demonstrated the effectiveness of the structured nursing intervention in enhancing sleep quality for middle-aged and elderly hemodialysis patients.
CONCLUSION
The structured nursing intervention program focusing on sleep hygiene education, relaxation techniques, and counseling effectively improved sleep quality among middle-aged and elderly hemodialysis patients. The significant decrease in the mean global PSQI score post-intervention indicates the positive impact of tailored nursing interventions in addressing poor sleep quality in this patient population. These findings emphasize the importance of implementing targeted nursing interventions to enhance the quality of life for hemodialysis patients by addressing the prevalent issue of poor sleep quality.
Causal associations between intermediate very-low-density lipoprotein cholesterol-to-total lipids ratio and peptic ulcer: A bidirectional Mendelian randomization study
Authors: Lin Chun-Mei , Meng Qian , Li Ying-Jun , Zhang Shuang-Xi , Luo Qiong-Xi , Dai Zhen-Yu 
Published: July 2024

BACKGROUND
Previous epidemiologic investigations have consistently demonstrated a strong association between the ratio of cholesterol to total lipids in medium very-low-density lipoprotein (VLDL) and the occurrence of peptic ulcers (PU). However, the precise causal relationship between these factors remains ambiguous. Consequently, this study aims to elucidate the potential correlation between the ratio of cholesterol to total lipids in medium VLDL and the incidence of peptic ulcer.
AIM
To investigate the ratio of cholesterol to total lipids in medium very-low-density lipoprotein (VLDL) association with PU via genetic methods, guiding future clinical research.
METHODS
Genome-wide association study (GWAS) datasets for the ratio of cholesterol to total lipids in intermediate VLDL and peptic ulcer were retrieved from the IEU OpenGWAS project (https://gwas.mrcieu.ac.uk ). For the forward Mendelian randomization (MR) analysis, 72 single nucleotide polymorphisms (SNPs) were identified as instrumental variables. These SNPs were selected based on their association with the ratio of cholesterol to total lipids in intermediate VLDL, with peptic ulcer as the outcome variable. Conversely, for the inverse MR analysis, no SNPs were identified with peptic ulcer as the exposure variable and the ratio of cholesterol to total lipids in intermediate VLDL as the outcome. All MR analyses utilized inverse variance weighted (IVW) as the primary analytical method. Additionally, weighted median and MR-Egger methods were employed as supplementary analytical approaches to assess causal effects. Egger regression was used as a supplementary method to evaluate potential directional pleiotropy. Heterogeneity and multiplicity tests were conducted using the leave-one-out method to evaluate result stability and mitigate biases associated with multiple testing.
RESULTS
The genetically predicted ratio of cholesterol to total lipids in medium VLDL was significantly associated with an elevated risk of peptic ulcer (IVW: OR = 2.557, 95%CI = 1.274-5.132, P = 0.008). However, no causal association of peptic ulcer with the ratio of cholesterol to total lipids in medium VLDL was observed in the inverse Mendelian randomization analysis.
CONCLUSION
In conclusion, our study reveals a significant association between the ratio of cholesterol to total lipids in medium VLDL and an elevated risk of peptic ulcers. However, further validation through laboratory investigations and larger-scale studies is warranted to strengthen the evidence and confirm the causal relationship between these factors.
Rare giant intradural epidural hemolymphangioma: A case report
Authors: Sun Shou-Feng , Wang Xue-Hua , Yuan Ying-Ying , Shao Yuan-Dong 
Published: July 2024

BACKGROUND
Hemolymphangioma is a rare, noninvasive benign tumor that originates from vascular and lymphatic malformations. It is usually congenital and can present with varying symptoms depending on its location and size. There are very few reports of hemolymphangiomas within the spinal canal, and giant lesions are exceptionally rare.
CASE SUMMARY
In July 2023, a 64-year-old male with a giant intravertebral epidural hemolymphangioma from thoracic 11 to lumbar 2 (T11-L2) was admitted to the Department of Spine Surgery at the People's Hospital of Binzhou City, China. The patient experienced progressive lumbar and left lower limb pain, numbness, weakness in both lower limbs, and difficulty with urination and defecation. Imaging studies revealed a large cystic mass in the spinal canal at T11-L2. Surgical decompression was performed, and the pathology confirmed hemolymphangioma.
CONCLUSION
Complete resection of hemolymphangiomas has the best prognosis, and final diagnosis relies on pathologic diagnosis. In this case, the mass was removed intact with a pedicle nail rod system, leading to adequate spinal decompression and restoration of spinal stability.
Risk factors for unsuccessful reduction of chronic Monteggia fractures in children treated surgically
Authors: Wang WenTao , Xiong Zhu , Huang DianHua , Li YiQiang , Huang YuLing , Guo YueMing , Andreacchio Antonio , Canavese Federico , Chen ShunYou 
Published: July 2024

AimsTo investigate the risk factors for unsuccessful radial head reduction (RHR) in children with chronic Monteggia fractures (CMFs) treated surgically.MethodsA total of 209 children (mean age 6.84 years (SD 2.87)), who underwent surgical treatment for CMFs between March 2015 and March 2023 at six institutions, were retrospectively reviewed. Assessed risk factors included age, sex, laterality, dislocation direction and distance, preoperative proximal radial metaphysis width, time from injury to surgery, reduction method, annular ligament reconstruction, radiocapitellar joint fixation, ulnar osteotomy, site of ulnar osteotomy, preoperative and postoperative ulnar angulation, ulnar fixation method, progressive ulnar distraction, and postoperative cast immobilization. Independent-samples t-test, chi-squared test, and logistic regression analysis were used to identify the risk factors associated with unsuccessful RHR.ResultsRedislocation occurred during surgery in 48 patients (23%), and during follow-up in 44 (21.1%). The mean follow-up of patients with successful RHR was 13.25 months (6 to 78). According to the univariable analysis, time from injury to surgery (p = 0.002) and preoperative dislocation distance (p = 0.042) were identified as potential risk factors for unsuccessful RHR. However, only time from injury to surgery (p = 0.007) was confirmed as a risk factor by logistic regression analysis. Receiver operating characteristic curve analysis and chi-squared test confirmed that a time from injury to surgery greater than 1.75 months increased the rate of unsuccessful RHR above the cutoff (p = 0.002).ConclusionTime from injury to surgery is the primary independent risk factor for unsuccessful RHR in surgically treated children with CMFs, particularly in those with a time from injury to surgery of more than 1.75 months. No other factors were found to influence the incidence of unsuccessful RHR. Surgical reduction of paediatric CMFs should be performed within the first two months of injury whenever possible.Cite this article: Bone Jt Open 2024;5(7):581–591.
The enhancive effect of the 2014–2016 El Niño-induced drought on the control of soil-transmitted helminthiases without anthelmintics: A longitudinal study
Authors: Pattanawongsa Attarat , Kammaneechan Pattanasak , Na-ek Prasit , Sedionoto Blego , Anamnart Witthaya 
Published: July 2024

Background
Soil-transmitted helminthiases (STHs) are common in tropical and subtropical regions. Southern Thailand experiences an extended rainy season, leading to persistently moist soil. This condition supports the life cycle of STHs, hindering effective control due to reinfection and low drug efficacy. We implemented a novel STH control strategy during the dry season aimed at decreasing reinfection rates without enhancing sanitation or hygiene practices. However, there were unexpected, prolonged droughts linked to El Niño events from 2014 to 2016. Additionally, we assessed the effects of these drought conditions on further control measures without the use of anthelmintics.

Methodology/Principal findings
A longitudinal study was conducted from 2012 to 2016. Stool samples collected from 299 participants were analyzed using the Kato-Katz and agar plate culture methods. Participants who tested positive for STHs received a single 400 mg dose of albendazole. The efficacy of the treatment was evaluated three weeks later. To confirm the control measures were implemented during the dry season, we monitored the number of rainy days following albendazole treatment for 52 days, of which 38 were without rain. Follow-up stool examinations were carried out in 2013 and 2016, with no additional doses of albendazole administered. Rainfall and rainy day data, which served as indicators of unexpected droughts due to El Niño, were collected from the nearest local meteorological stations. Before the drought, there was a decrease in STH prevalence in 2013—except for trichuriasis—attributable to the dry season control efforts. Despite these efforts, STH prevalence remained high. Remarkably, in 2016, following the drought period, the prevalence of trichuriasis, which had not changed previously, spontaneously declined without further albendazole treatment compared to 2013.
Furthermore, the prevalence of strongyloidiasis remained unchanged likely due to its low susceptibility to drought conditions, as it can reproduce within hosts. Conversely, the prevalence of other STHs consistently declined. The drought and possible improvements in sanitation and hygiene practices contributed to this decrease by reducing rates of reinfection and new infection and by increasing the natural cure rate. Additionally, some participants infected with hookworms or Trichuris who were not cured by albendazole experienced natural remission.

Conclusions/Significance
Control measures implemented during the dry season, combined with a 14-month-long drought induced by the El Niño event of 2014–2016, and some improvements in sanitation and hygiene practices, contributed to a decrease in both the prevalence and intensity of STHs, except for S. stercoralis. Over time, S. stercoralis is likely to become the predominant species among the STHs.
The impact of hospital presentation time on stroke outcomes: A nationally representative Irish cohort study
Authors: Loughlin Elaine , Gabr Ahmed , Galvin Rose , McCormack Joan , Brych Olga , O’Donnell Martin J. , Collins Rónán , Thornton John , Harbison Joseph , O’Connor Margaret 
Published: July 2024

Objectives
There is conflicting evidence regarding the outcomes of acute stroke patients who present to hospital within normal working hours (‘in-hours’) compared with the ‘out-of-hours’ period. This study aimed to assess the effect of time of stroke presentation on outcomes within the Irish context, to inform national stroke service delivery.

Materials and methods
A secondary analysis of data from the Irish National Audit of Stroke (INAS) from Jan 2016 to Dec 2019 was carried out. Patient and process outcomes were assessed for patients presenting ‘in-hours’ (8:00–17:00 Monday-Friday) compared with ‘out-of-hours’ (all other times).

Results
Data on arrival time were available for 13,996 patients (male 56.2%; mean age 72.5 years), of which 55.7% presented ‘out-of-hours’. In hospital mortality was significantly lower among those admitted ‘in-hours’ (11.3%, n = 534) compared with ‘out-of-hours’ (12.8%, n = 749); (adjusted Odds Ratio (OR) 0.82; 95% Confidence Interval CI [95% CI] 0.72–0.89). Poor functional outcome at discharge (Modified Rankin Scale ≥ 3) was also significantly lower in those presenting ‘in-hours’ (adjusted OR 0.79; 95% CI 0.68–0.91). In patients receiving thrombolysis, mean door to needle time was shorter for ‘in-hours’ presentation at 55.8 mins (n = 562; SD 35.43 mins), compared with ‘out-of-hours’ presentation at 80.5 mins (n = 736; SD 38.55 mins, p < .001).

Conclusion
More than half of stroke patients in Ireland present ‘out-of-hours’ and these presentations are associated with a higher mortality and a lower odds of functional independence at discharge. It is imperative that stroke pathways consider the 24 hour period to ensure the delivery of effective stroke care, and modification of ‘out-of-hours’ stroke care is required to improve overall outcomes.
Comparative Risk of Serious Infection With Vedolizumab vs Anti-Tumor Necrosis Factor in Inflammatory Bowel Disease: Results From Nationwide Swedish Registers
Authors: Karlqvist Sara , Sachs Michael C. , Eriksson Carl , Cao Yang , Montgomery Scott , Ludvigsson Jonas F. ,   The SWIBREG Study Group, Olén Ola , Halfvarson Jonas 
Published: July 2024

INTRODUCTION:
We aimed to assess the risk of serious infection in patients with inflammatory bowel disease (IBD) treated with vedolizumab compared with those treated with anti-tumor necrosis factors (TNF) and the general population.

METHODS:
In this Swedish cohort study, treatment episodes were identified from nationwide health registers. We used Cox regression with propensity score-matched cohorts to estimate hazard ratios (HRs) for incident serious infections, defined as infections requiring hospital admission.

RESULTS:
During 1,376 treatment episodes in Crohn's disease, the rate of serious infections per 100 person-years (PY) was 5.18 (95% CI = 3.98–6.63) with vedolizumab vs 3.54 (95% CI = 2.50–4.85) with anti-TNF; HR = 1.72 (95% CI = 1.12–2.65), partly explained by more gastrointestinal infections. Compared with the rate of 0.75/100 PY (95% CI = 0.59–0.92) in a matched general population cohort, vedolizumab demonstrated higher risk (HR = 7.00; 95% CI = 5.04–9.72). During 1,294 treatment episodes in ulcerative colitis, the corresponding rates were 3.74/100 PY (95% CI = 2.66–5.11) with vedolizumab vs 3.42/100 PY (95% CI = 2.31–4.89) with anti-TNF; HR = 0.80 (95% CI = 0.47–1.36) during the initial 1.1 years and HR = 2.03 (95% CI = 0.65–6.32) after 1.1 years (truncated due to nonproportional hazards). Pneumonia accounted for 40% of all infections among anti-TNF, whereas no case was observed among vedolizumab episodes. Compared with the rate of 0.69/100 PYs (95% CI = 0.53–0.87) in a matched general population cohort, vedolizumab showed an HR of 5.45 (95% CI = 3.67–8.11).

DISCUSSION:
Vedolizumab was associated with increased risks of serious infections compared with anti-TNF in Crohn's disease but not in ulcerative colitis. Nonetheless, the panorama of serious infections seemed to differ between the drugs. Our findings underscore the importance of clinical awareness of infections and the safety profile of the 2 therapies.
Жизненные выборы на разных этапах жизненного пути — автобиографии одного поколения
Authors: Андреенкова Анна Владимировна 
Published: July 2024

Статья посвящена изучению жизненных выборов людей на протяжении их жизненного пути на основе событийного анализа автобиографий и глубинных интервью с респондентами поколения 1960―1975 гг. рождения. Из всех жизненных событий, упомянутых как значимые в автобиографиях или определенных как таковые в глубинных интервью, три четверти представляли собой ситуации выбора. Ситуация выбора характеризуется пространством выбора ― широтой и свободой от серьезных ограничений. 40% всех ситуаций выбора были отнесены к категории ситуаций с широким выбором, 30% ― к ситуациям выбора с существенными ограничениями, 20% ― с узким выбором. Ограничениями выступали материальные сложности, инфраструктурные возможности, а также внешние нормативные и внутренние ценностные факторы, предыдущие решения и решения других людей. Для разных социальных групп пространство выбора неодинаково. В ситуациях узкого или ограниченного выбора женщины оказываются чаще, чем мужчины; люди с низким социально-экономическим статусом ― чаще, чем люди со средним или высоким статусом.
Автор предлагает схему-классификацию характера выбора, выделяя нормативный, активно-созидательный, вынужденный и конформный выборы. Около половины жизненных выборов делаются на нормативных основаниях, около трети ― активно-созидательных, гораздо менее распространены вынужденный и конформный. Позитивные последствия с точки зрения самореализации человека чаще возникают в результате активно-созидательного выбора, реже ― нормативного. Ситуации выбора-преодоления или конформного выбора в большинстве случаев влекут негативные последствия. Факторы, способствующие жизненному выбору с позитивными долговременными результатами, ― благоприятные социально-исторические условия, готовность к изменениям и определенному риску, независимость в принятии решений, осознанность собственных желаний и целей.
Жизненный выбор людей из поколения, рожденного в 1960―1975 гг. и взрослевшего во время радикальных трансформаций 1990-х, был ограничен как институциональными и общими социетальными условиями, так и ценностно-нормативными факторами. В ходе анализа выделены такие концептуальные особенности жизненного выбора, как сложная субъектность, ограниченность в рациональности, зависимость от предыдущих выборов и выборов других людей, а также долгосрочность последствий.
Благодарность. Работа выполнена в рамках гранта РНФ 23-18-00635 «Жизненный путь, ценности, ожидания поколения, взрослевшего в 1990-е, ― лонгитюдное исследование через 30 лет».
Application of Plant-Based Metal Nanomedicine in Treatment of Various Types of Cancer: A Review
Authors: Hernawan Jihan Nurafifah , Sardjono Ratnaningsih Eko 
Published: July 2024

Background: Plant-based nanomedicine is a rapidly growing field of research that utilizes plant-derived nanoparticles for the treatment of cancer. Nanoparticles from plant extracts have a number of advantages over synthetic nanoparticles, including biocompatibility, low toxicity, and ease of synthesis Objective: This article comprehensively explores the synthesis, characterization, and anticancer activities of silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and gold nanoparticles (AuNPs) synthesized using various plant extracts Methods: The research method used in this article is Systematic Literature Review (SLR). The research method used in this article is the Systematic Literature Review (SLR). The data are collected using Harzing’s Publish or Perish. The included literature sources discuss the synthesis and characterization of plant-based nanoparticles as anticancer, are published within the last 5 years, and are indexed in Google Scholar Results: Various synthesis methods influence the properties and cytotoxic effects of silver, zinc oxide, and gold nanoparticles derived from plant extracts. Characterization techniques provide insights into their synthesis, morphology, crystalline structure, surface chemistry, and stability. Conclusion: The results of this study reveal that silver nanoparticles (AgNPs), zinc oxide nanoparticles (ZnO-NPs), and gold nanoparticles (AuNPs) synthesized from plants have great potential in the treatment of various types of cancer.
Comparison of fatigue lifetime of new generation CAD/CAM crown materials on zirconia and titanium abutments in implant-supported crowns: a 3D finite element analysis
Authors: Deste Gökay Gonca , Gökçimen Gülsüm , Oyar Perihan , Durkan Rukiye 
Published: July 2024

Abstract

Objectives
Due to the dynamic character of the stomatognathic system, fatigue life experiments simulating the cyclic loading experienced by implant-supported restorations are critical consideration. The aim of this study was to examine the effect of different crown and abutment materials on fatigue failure of single implant-supported crowns.

Methods
Models were created for 10 different designs of implant-supported single crowns including two zirconia-reinforced lithium silicates (crystallized and precrystallized), monolithic lithium disilicate, polymer-infiltrated ceramic networks, and polyetheretherketone supported by zirconia and titanium abutments. A cyclic load of 179 N with a frequency of 1 Hz was applied on palatal cusp of a maxillary first premolar at a 30° angle in a buccolingual direction.

Results
In the models with titanium abutments, the polymer-infiltrated ceramic network model had a lower number of cycles to fatigue failure values in the implant (5.07), abutment (2.30), and screw (1.07) compared to others. In the models with zirconia abutments, the crystallized zirconia-reinforced lithium silicate model had a higher number of cycles to fatigue failure values in the abutment (8.52) compared to others. Depending on the fatigue criteria, polyetheretherketone implant crown could fail in less than five year while the other implant crowns exhibits an infinite life on all models.

Conclusions
The type of abutment material had an effect on the number of cycles to fatigue failure values for implants, abutments, and screws, but had no effect on crown materials. The zirconia abutment proved longer fatigue lifetime, and should thus be considered for implant-supported single crowns.
Anatomic variability of the human femur and its implications for the use of artificial bones in biomechanical testing
Authors: Hollensteiner Marianne , Traweger Andreas , Augat Peter 
Published: July 2024

Abstract
Aside from human bones, epoxy-based synthetic bones are regarded as the gold standard for biomechanical testing os osteosyntheses. There is a significant discrepancy in biomechanical testing between the determination of fracture stability due to implant treatment in experimental methods and their ability to predict the outcome of stability and fracture healing in a patient. One possible explanation for this disparity is the absence of population-specific variables such as age, gender, and ethnicity in artificial bone, which may influence the geometry and mechanical properties of bone. The goal of this review was to determine whether commercially available artificial bones adequately represent human anatomical variability for mechanical testing of femoral osteosyntheses. To summarize, the availability of suitable bone surrogates currently limits the validity of mechanical evaluations of implant-bone constructs. The currently available synthetic bones neither accurately reflect the local mechanical properties of human bone, nor adequately represent the necessary variability between various populations, limiting their generalized clinical relevance.