bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of historical disease conditions on mortality and life expectancy in patients with advanced schistosomiasis in Hunan Province, China
Authors: Jiang Honglin , Zhou Jie , Cai Xinting , Hu Benjiao , Wang Huilan , Fu Chen , Xu Ning , Gong Yanfeng , Tong Yixin , Yin Jiangfan , Huang Junhui , Wang Jiamin , Jiang Qingwu , Liang Songyue , Zhou Yibiao 
Published: August 2024

Abstract

Background
Although the prognosis of advanced schistosomiasis patients has significantly improved, the impact of historical disease conditions on life expectancy remains unclear.

Methods
Utilizing data from an advanced schistosomiasis cohort (n=10 362) from 2008 to 2019 in Hunan, China, we examined five historical disease conditions: times of praziquantel treatment, the history of ascites, splenectomy, upper gastrointestinal bleeding (UGIB) and hepatic coma. Using latent class analysis, participants were categorized into three groups: Group 1 (characterized by no risk conditions), Group 2 (had ≤3 times of praziquantel treatment without UGIB history) and Group 3 (had UGIB history). Life expectancies were calculated using the life table method.

Results
At the age of 45 y, patients with ≤3 times of praziquantel treatment, a history of ascites, UGIB, hepatic coma and those without splenectomy exhibited lower life expectancies. Groups 1, 2 and 3 had estimated life expectancies of 32.32, 26.76 and 25.38 y, respectively. Compared with Group 1, women in Group 3 experienced greater life expectancy loss than those in Group 2, with the difference narrowing with age.

Conclusions
Based on the consideration of overall physical conditions, tailored treatment and healthcare, along with public health interventions targeting diverse populations, could mitigate the prevalence of poor disease conditions and premature deaths.
Analysis of Rice Blast Fungus Genetic Diversity and Identification of a Novel Blast Resistance OsDRq12 Gene
Authors: Zhao Dan-Dan , Chung Hyunjung , Jang Yoon-Hee , Farooq Muhammad , Choi Soo Yeon , Du Xiao-Xuan , Kim Kyung-Min 
Published: August 2024

The rice blast fungus Magnaporthe oryzae poses a significant challenge to maintaining rice production. Developing rice varieties with resistance to this disease is crucial for its effective control. To understand the genetic variability of blast isolates collected between 2015 and 2017, the 27 monogenic rice lines that carry specific resistance genes were used to evaluate blast disease reactions. Based on criteria such as viability, virulence, and reactions to resistance genes, 20 blast isolates were selected as representative strains. To identify novel resistance genes, a quantitative trait locus analysis was carried out utilizing a mixture of the 20 representative rice blast isolates and a rice population derived from crossing the blast-resistant cultivar ‘Cheongcheong’ with the blast-susceptible cultivar ‘Nagdong’. This analysis revealed a significant locus, RM1227-RM1261 on chromosome 12, that is associated with rice blast resistance. Within this locus, 12 disease resistance-associated protein genes were identified. Among them, OsDRq12, a member of the nucleotide-binding, leucine-rich repeat disease resistance family, was chosen as the target gene for additional computational investigation. The findings of this study have significant implications for enhancing rice production and ensuring food security by controlling rice blast and developing resistant rice cultivars. [Formula: see text] Copyright © 2024 The Author(s). This is an open access article distributed under the CC BY-NC-ND 4.0 International license .
Perceptions of Key Responsibilities and Professional Development Interests of Senior Educational Leaders: A Needs Assessment
Authors: Bidwell Duane R. , Samuel Anita , Cervero Ronald M. , Durning Steven J. , Stephan Sherri L. , Patel Erin L. , Bowman Marjorie A. , Meyer Holly S. 
Published: August 2024

Abstract

Purpose
High-ranking educational leaders in academic medicine oversee multiple clinical programs. This requires them to prioritize dozens of emergent tasks and responsibilities daily, from educational policy and strategy to staff management, financial planning, onboarding of trainees, and facility planning and management. Identifying their key responsibilities and frequently used skills and competencies may clarify the educational needs of senior educational leaders and facilitate targeted professional development to promote effective and efficient performance.

Method
In August 2022, researchers interviewed 12 designated education officers (DEOs) from U.S. Department of Veterans Affairs (VA) Veterans Health Administration medical centers about their daily work and most challenging responsibilities. Content analysis of interview transcripts identified key responsibilities and activities identified by participants and prioritization of the perceived skills needed to complete them.

Results
Participants emphasized 4 key areas of responsibility: fiscal, administrative, affiliate partnership, and educational duties. They identified 12 skills as baseline requirements for effective performance for which additional professional development would be useful and suggested that both new and more established educational leaders receive targeted professional development and mentoring to foster these capacities.

Conclusions
The key skills participants identified by area of perceived responsibility are relevant to VA DEOs, designated institutional officers, and senior academic leaders who develop health professions education programs, oversee clinical training, and manage educational change. Structured orientation programs and ongoing professional development for senior educational leaders could emphasize these areas of responsibility, potentially enriching DEOs’ performance and reducing burnout.
Chronic consequences of accidental dural puncture and postdural puncture headache in obstetric anaesthesia – sieving through the evidence
Authors: Armstrong Sarah , Fernando Roshan 
Published: August 2024

Purpose of review
Accidental dural puncture (ADP) and postdural puncture headache (PDPH) are relatively common complications of neuraxial anaesthesia and analgesia in obstetrics. Both may result in acute and chronic morbidity. This review intends to discuss the chronic implications of ADP and PDPH and raise awareness of severe and potentially life-threatening conditions associated with them.

Recent findings
ADP may be associated with a high rate of PDPH, prolonged hospitalization and increased readmissions. Studies have shown that PDPH may lead to chronic complications such as post-partum depression (PPD), post-traumatic stress disorder (PTSD), chronic headache, backache and reduced breastfeeding rates. There are many case reports indicating that major, severe, life-threatening neurologic complications may follow PDPH in obstetric patients including subdural haematoma and cerebral venous thrombosis.

Summary
Many clinicians still believe that ADP and PDPH are benign and self-limiting conditions whereas there may be serious and devastating consequences of both. It is imperative that all women with ADP and PDPH are appropriately diagnosed and treated.
Dimensions of posttraumatic stress disorder and menopause-related health in midlife women veterans
Authors: Thomas Jordan L. , Blanken Anna E. , Huang Alison J. , Maguen Shira , Gibson Carolyn J. , Sumner Jennifer A. 
Published: August 2024

Abstract

Objective
Posttraumatic stress disorder (PTSD) has been linked with menopause symptoms (eg, vasomotor, urinary) and their sequelae (eg, sexual difficulties). However, PTSD is a heterogeneous disorder, and less is known about which aspects may be most associated with menopause-related health.

Methods
Using confirmatory factor analyses, we evaluated five structural models of PTSD symptoms in 208 predominately postmenopausal women veterans (aged 45-64 years). We investigated associations between PTSD—operationalized as a probable diagnosis and symptom dimensions of the best-fitting model—and common menopause-related health concerns, including (1) vasomotor, urinary, and vaginal symptoms; (2) vasomotor symptom interference; and (3) sexual functioning.

Results
A six-factor anhedonia model—comprising re-experiencing, avoidance, negative affect, anhedonia, anxious arousal, and dysphoric arousal—provided optimal fit. Both probable PTSD and greater symptoms across all dimensions were linked with presence of urinary and vasomotor, but not vaginal, symptoms. Comparing dimensions revealed that negative affect and dysphoric arousal were particularly associated with urinary symptoms, whereas dysphoric arousal was the factor most strongly related to vasomotor symptom interference. Associations between PTSD and sexual dysfunction were mixed; whereas there was no relation with probable diagnosis, all dimensions were linked with adverse sexual sequelae.

Conclusions
PTSD—considered categorically and dimensionally—was relevant to menopause-related health in midlife women veterans. Further, symptoms of negative affect and dysphoric arousal were particularly related to urinary and vasomotor symptoms. These specific symptoms may drive associations between PTSD and these aspects of menopause-related health. Clinical interventions targeting these symptoms may promote midlife women's health.
Sex differences in all-cause mortality and life span between women with premature menopause and men: propensity score matching analysis
Authors: Xing Zailing , Kirby Russell S. 
Published: August 2024

Abstract

Objective
This study investigated sex differences in all-cause mortality and life span between women undergoing premature menopause and men using propensity score matching analysis.

Methods
Data were from the National Health and Nutrition Examination Survey (1999‐2018) and the National Health and Nutrition Examination Survey III (1988‐1994). We included 3,214 women experiencing premature menopause and 23,067 men. The participants were all older than 40 years. Propensity score matching analysis created matched cohorts of women and men using a 1:1 ratio. We employed Cox proportional hazard models to estimate unadjusted and adjusted hazard ratios (HR) (95% confidence interval [CI]) for the association between sex and both all-cause mortality and survival up to the 75th percentile of life span. A subgroup analysis examined the effects of hormone therapy on mortality and life span.

Results
Compared with men in the matched cohorts, the adjusted HR values (95% CI) for all-cause mortality in women with age at menopause at <35, 35 to 39, and <40 years were 0.65 (0.54-0.78), 0.72 (0.59-0.87), and 0.67 (0.60-0.76), respectively. However, the adjusted HR values (95% CI) for women and men to survive to the 75th percentile of life span were not statistically significant. Besides, there was no significant difference in the mean life span between deceased women and men in the matched cohorts. In the subgroup analysis, the mean life span did not differ significantly between deceased women taking hormone therapy and men. However, the average life span of women never using hormone therapy was significantly longer than that of men (78.3 ± 11.6 vs 76.6 ± 11.9 years, P = 0.0154).

Conclusions
Women experiencing premature menopause had lower risks of all-cause mortality than men, but the advantage that women had in terms of life span was insignificant.
Effectiveness of 0.3% Hyaluronic Acid Eye Drops for Benign Essential Blepharospasm and Hemifacial Spasm with Botulinum Toxin–induced Dry Eye
Authors: Poonyathalang Anuchit , Tiraset Nanida , Rattanathamsakul Natthapon 
Published: August 2024

Background:
This study evaluates the effectiveness of 0.3% hyaluronic acid (HA) eye drops in patients receiving concurrent botulinum toxin (BoNT) injections for benign essential blepharospasm (BEB) or hemifacial spasm (HFS).

Methods:
This randomized controlled cross-over trial study involved 14 patients with BEB and 33 patients with HFS randomized into two groups (early treatment and deferred treatment) for 3 months of treatment with 0.3% HA eye drops. Data collected at baseline, 3 months, and 6 months included Blepharospasm Severity Scale (BSS) score in patients with BEB; Samsung Medical Class Grading Scale score in patients with HFS; and dry eye symptoms, lower eyelid tear meniscus height (TMH), tear breakup time (TBUT), and corneal fluorescein staining in both groups.

Results:
After 3 months of 0.3% HA instillation, patients with BEB in both groups showed significant improvement in BSS, TMH, TBUT, and the amelioration of subjective dry eye symptoms and corneal staining (P < 0.05). However, discontinuation of 0.3% HA eye drops worsened BSS, TMH, and TBUT. Patients with HFS also experienced significant improvement in Samsung Medical Class score, subjective dry eye symptoms, and objective corneal findings (P < 0.05).

Conclusions:
Treatment with 0.3% HA eye drops led to significant improvement in spasm severity, and dry eye parameters, after 3 months of instillation in patients with BEB or HFS during concurrent treatment with BoNT injections. The 0.3% HA eye drops were safe and might serve as an add-on treatment for symptom improvement.
Sexual Health Implications of Return Migration for Women and Their Partners in Rural Mexico: A Critical Ethnography
Authors: Fernandez-Sanchez Higinio , Rocha-Fernandez Minerva , Salma Jordana , Santa Maria Diane M. , Benavides-Torres Raquel A. , Salami Bukola 
Published: August 2024

Abstract
The return of a migrant partner can negatively impact the sexual health of women who stayed in their communities. Understanding their sexual health needs is crucial for developing targeted interventions and support systems. Our study used a critical ethnographic approach in Agua Dulce, a rural community in Mexico, involving 50 key informants: women who stayed behind (n = 20), returnees (n = 12), community leaders (n = 12), and health care professionals (n = 6). We used participant observation, policy analysis, and interviews, using purposeful and snowball sampling methods. A gender-based thematic analysis revealed economic hardships and early separations affect the sexual well-being of women who stay behind. Infidelity, discovered through social media or calls, causes emotional distress and family disruptions. Male migrants spend an average of 8.85 years abroad, leading to fears of risky sexual behaviors. Our study highlights the urgent need for specialized support centers and comprehensive health interventions.
Viral infection after hematopoietic stem cell transplantation
Authors: Ljungman Per 
Published: August 2024

Purpose of review
Viral infections are important complications after allogeneic hematopoietic stem cell transplantation. New infections develop such as SARS-CoV-2 with the potential for severe consequences. In this review, newly published information regarding management of viral infections is discussed.

Recent findings
Letermovir and maribavir are antiviral agents that have positively impacted the management of cytomegalovirus infections. These should today be included in treatment algorithms. The first antiviral cellular therapy for anti-CD20 refractory EBV-associated lymphoproliferative disease is now licensed and available. Vaccination as well as introduction of antiviral agents, mAbs and possibly the development of different viral strains have reduced mortality in COVID-19 in this patient population. Well designed studies have shown the improved immunogenicity of high-dose influenza vaccines. There is still an unmet medical need for patients infected with human metapneumovirus and parainfluenza viruses.

Summary
Although improvements in patient management for several important posttransplantation viral infections have been reported, an unmet medical need still exists for other viruses occurring in this high-risk population.
An algerian three-month-old infant with juvenile myelomonocytic leukemia and noonan syndrome: a case report and review of literature
Authors: Nora Boukouira , Sabrinel Ferrache Wiam , Yassamine Ouerdane , Touri Nabila Souad , Samira Guemghar , Abdulrazzak Mohammed , Jobran Afnan W. M. , Keiji Leila 
Published: August 2024

Introduction and Importance:
Juvenile myelomonocytic leukemia (JMML) is a rare childhood malignancy. Noonan syndrome (NS), a genetic disorder, is occasionally associated with an increased risk of JMML. Mutations in the Ras signaling pathway are implicated in both conditions.

Case Presentation:
We report a case of a 3-month-old infant diagnosed with JMML. The infant displayed features suggestive of NS. Using the WHO 2016 criteria the diagnosis of JMML was made. Despite initial concerns, the infant exhibited a marked clinical response without specific anti-leukemic therapy, with significant improvement in symptoms and blood counts.

Clinical Discussion:
This case highlights the importance of maintaining a high index of suspicion for JMML in infants with NS features, particularly monocytosis and splenomegaly. It also underscores the potential for variable presentations of JMML, including cases with a more indolent course. While genetic confirmation was unavailable, the clinical picture suggests a possible link between the underlying Ras pathway mutations and the infant’s favorable response.

Conclusion:
In the patients exhibit NS features, monocytosis, and splenomegaly, clinicians should keep an eye out for juvenile myelomonocytic leukemia (JMML). Given that both illnesses may be influenced by similar underlying mutations in the Ras pathway.
Long-Term Weight Loss and Comorbidity Resolution of Laparoscopic Sleeve Gastrectomy and Laparoscopic Roux-en-Y Gastric Bypass and the Impact of Preoperative Weight Loss on Overall Outcome
Authors: Lucocq James , Homyer Kate , Geropoulos Georgios , Thakur Vikram , Stansfield Daniel , Joyce Brian , Drummond Gillian , Tulloh Bruce , de Beaux Andrew , Lamb Peter J. , Robertson Andrew G. 
Published: August 2024

Background:
The impact of preoperative weight loss on long-term weight loss outcomes and comorbidity resolution in both laparoscopic sleeve gastrectomy (LSG) and laparoscopic Roux-en-Y gastric bypass (LRYGB) are poorly reported. Understanding this relationship is necessary to guide surgeons toward appropriate procedure and patient selection. The present study investigates long-term weight loss outcomes and comorbidity resolution following LSG and LRYGB and investigates the effect of preoperative variables on long-term outcomes.

Methods:
All patients who underwent LSG and LRYGB (2008-2022) in a tertiary referral centre were followed up prospectively. From 2010, a 12-week intensive preoperative information course (IPIC) became standard practice to optimize preoperative weight loss. Excess weight loss outcomes (EWL≥50% and ≥70%) were compared between LSG and LRYGB using multivariate logistic regression and the effect of preoperative weight loss on weight loss and comorbidity resolution, improvement, and exacerbation were reported.

Results:
A total of 319 patients (median age: 49 y; M:F, 75:244) were included (158 LSG: 161 LRYGB). During follow-up, 260 (81.5%) and 163 patients (51.1%) achieved EWL≥50% and ≥70%, respectively. Those with sustained EWL≥50% and EWL≥70% at the end of follow-up were more likely to have underwent a LRYGB versus a LSG (59.6% vs. 40.4%, P=0.002; 61.7% vs. 38.3%, P<0.001). IPIC and higher preoperative weight loss (HR: 2.59 to 3.72, P<0.001) increased rates of EWL≥50% and EWL70% for both procedures. Improvement or resolution of type-2 diabetes were significant (72.7%), but up to 27.3% of patients developed or suffered an exacerbation of a psychiatric illness.

Conclusions:
Excess weight loss outcomes are similar for LSG and LRYGB but LRYGB results in higher rates of sustained excess weight loss during long-term follow-up. Preoperative weight loss improves long-term weight loss. Comorbidity resolution is significant but rates of psychiatric illness exacerbation are high following metabolic and bariatric surgery.
Self-actualization of families with a cerebrovascular disease patient by nurses, and of self-actualization of nurses themselves: An integrative review based on Family Care/Caring Theory
Authors: Ota Hiroko , Hohashi Naohiro 
Published: August 2024

AbstractBackground and purposeWhen caring for patients hospitalized with cerebrovascular disease, a caring phenomenon occurs between the patient’s family and the nurse, and according to Hohashi’s Family Care/Caring Theory, the family and the nurse achieve self-actualization. However, the contents of self-actualization through specific care/caring are unclear. The purpose of this integrative review was to clarify the self-actualization of the nurse as an outcome of family care/caring, and the self-actualization of other individuals (that is, the family) who are supported by nurses.MethodsConducting a search using Ichushi-Web, CiNii and J-STAGE, which are extensive Japanese literature databases, 1,061 original articles were identified using the keywords “cerebrovascular disease AND nurse.” The quality of the articles was assessed according to the Joanna Briggs Institute critical appraisal checklists. We conducted an integrative review of 11 articles describing transactions between nurses and families according to Toronto and Remington. Self-actualization of the nurse and self-actualization of other individuals were classified as subcategories and then as categories.ResultsOf the 11 studies utilized, 10 were qualitative studies and one was a quantitative descriptive study. Eight categories were identified for self-actualization of families with a cerebrovascular patient by nurses, including “Families can realize their hopes through the provision of an environment by nurses.” Three categories of self-actualization of the nurse were identified, including “Nurses can obtain a sense of satisfaction from the family.”ConclusionDuring the recovery process after hospitalization for cerebrovascular disease, a caring phenomenon occurs between the patient’s family and nurses, which can be understood using Family Care/Caring Theory. The family’s self-actualization and the nurse’s self-actualization were achieved through reciprocal concern between the two.
The impact of urban vs rural environments on driving in ageing
Authors: Morrissey Sol , Jeffs Stephen , Gillings Rachel , Khondoker Mizanur , Fisher-Morris Mary , Manley Ed , Hornberger Michael 
Published: August 2024

AbstractBackground and objectivesOlder rural drivers are more dependent on driving than urban drivers to maintain community mobility due to reduced availability of transportation alternatives. Yet it is not understood how cognition impacts driving mobility and road safety across urban vs rural settings. The present study therefore aimed to establish whether cognitive changes impacted driving mobility and road safety differently across rural and urban older drivers.Research Design and Methods969 older drivers (mean age: 71.01) were recruited for a prospective cohort study. Participants completed self-reported driving behaviour and road traffic incident (RTI) history questionnaires before completing an objective cognitive testing battery to establish global cognitive functioning; and were invited back to repeat the study procedure one-year later.ResultsWe find that older rural drivers have a greater driving mobility than older urban drivers and are less likely to reduce their driving mobility over time, as only urban residents with cognitive decline reduced their driving space. We further corroborate previous findings that RTI incidence is greater within urban areas and establish a distinct association between worse cognitive functioning and RTI risk solely in urban residents.Discussion and implicationsOverall, we show for the first time how the interaction of age-related cognitive changes with geographical settings impact driving mobility and road safety in urban and rural areas. This paves the way for informed policymaking and future research directions to navigate driving cessation and improved road safety in ageing.