bluuebunny/crossref_metadata_2025_split huggingface dataset:
Failure rate of isolated medial meniscus repair in the stable knee: Systematic review and meta‐analysis
Authors: Farinelli Luca , Meena Amit , Montini Davide , Patralekh Mohit Kumar , Piritore Giuseppe , Grassi Marco , Gigante Antonio , Hoser Christian , Fink Christian , Tapasvi Sachin 
Published: August 2024

AbstractPurposeThe present meta‐analysis aims to determine the outcomes and failure rates for medial meniscus repairs in patients with stable knees.MethodsA literature search was conducted using PubMed and Scopus with the terms ‘(medial meniscus OR medial meniscal) AND (repair)’. The search strategy was based on the PRISMA (Preferred Reporting Items for Systematic Meta‐Analyses) protocol and included 93 articles assessed for eligibility. The search criteria were limited to studies reporting outcomes and failure rates. The exclusion criteria included languages other than English, biomechanical studies, letters to editors, non‐full text, review articles, meta‐analyses and case reports.ResultsIn total, 10 studies with 595 patients were included. Degenerative tears or studies reporting meniscus repair outcomes on root repairs, revision or primary anterior cruciate ligament reconstruction, discoid menisci or ramp lesions were excluded. All studies included revision surgery and/or clinical symptoms as failure definitions. The overall medial meniscal repair failure rate was 26% with a 95% confidence interval (CI) [15%−37%]. The mean time to failure from isolated medial meniscus repair surgery was 27.7 months with 95% CI [18.5−36.9 months]. The postoperative Lysholm and IKDC scores were reported in three articles. At the final follow‐up, the mean postoperative Lysholm and IKDC scores were 92.3 with 95% CI [84.5−100] and 88.6 with 95% CI [83.5−93.8], respectively.ConclusionThe current meta‐analysis revealed an overall failure rate of 26% in the case of medial meniscus repair in a stable knee. For these reasons, the patient should be aware of the substantial risk of revision surgery (one out of four cases). Medial meniscus repair in a stable knee yielded good clinical results.Level of EvidenceII.
Greater hip internal rotation range of motion is associated with increased dynamic knee valgus during jump landing, both before and after fatigue
Authors: Hodel Sandro , Imhoff Florian B. , Strutzenberger Gerda , Fitze Daniel , Obrist Simone , Vlachopoulos Lazaros , Scherr Johannes , Fucentese Sandro F. , Fröhlich Stefan , Spörri Jörg 
Published: August 2024

AbstractPurposeThe aim of this study was to analyse sex‐specific differences contributing to dynamic valgus in competitive soccer players before and after a standardised fatiguing protocol.MethodsThirty‐nine healthy female and male competitive soccer players (19 females and 20 males) were recruited for the purpose of this study. Bilateral medial knee displacement (MKD) was assessed during drop jump landings using a three‐dimensional motion capture system before and after a standardised fatiguing protocol. In addition, all soccer players underwent clinical examinations, including rotational hip range of motion (ROM), isokinetic strength testing and magnetic resonance imaging (MRI) of the hip and knee. Sex‐specific and fatigue‐dependent differences were reported, and the influence of demographic, clinical and radiographic factors on MKD was analysed via multiple linear regression models.ResultsCompared with male soccer players, female soccer players demonstrated a tendency towards increased MKD during drop jump landings before (p = 0.09) and after the fatiguing protocol (p = 0.04). Sex‐specific differences included increased hip internal rotation (IR) ROM, decreased hip external rotation (ER) strength and increased femoral torsion in females (all p < 0.002). According to the multiple linear regression models (stepwise method), increased hip IR ROM (90° of flexion) and the non‐dominant leg remained the sole independent predictors of increased MKD during drop jump landings before (p < 0.01 and p = 0.02, respectively) and after fatigue (p < 0.01 and p < 0.01, respectively). An increase in hip IR ROM in females was linearly related to MKD after fatigue (R2 = 0.25; p < 0.01).ConclusionFemale soccer players exhibited increased dynamic valgus before and after fatigue, which is likely attributed to joint mobility, as well as muscular and anatomical differences, such as increased hip IR ROM, reduced hip ER strength and increased femoral torsion. In particular, females with increased hip IR ROM were more susceptible to effects of fatigue on MKD, which may increase their risk for anterior cruciate ligament injury.Level of EvidenceLevel III.
Nickel allergy does not correlate with function after total knee arthroplasty
Authors: Chimento George , Daher Jimmy , Desai Bhumit , Velasco‐Gonzalez Cruz 
Published: August 2024

AbstractPurposeThe purpose of this study is to determine if there is a relationship between clinical outcomes and nickel allergy by evaluating asymptomatic total knee arthroplasty (TKA) patients with well‐functioning implants through quantitative metal allergy (MA) testing.MethodsA prospective case series was performed on 50 patients with well‐functioning TKA of various implant types. Inclusion criteria included primary TKA with a minimum 12‐month follow‐up and Oxford knee score (OKS) ≥ 40. A commercially available Lymphocyte Transformation Test measured the amount of a hypersensitivity lymphocyte immune response after exposure to a particular antigen. MA results were stratified based on the stimulation index (SI). The Cochran–Mantel–Haenzel test was used to test the homogeneity of metal reactivities. The Wilcoxon–Mann–Whitney test was used to compare individual metal SI by gender and the association of OKS and metal SI was ascertained with the Spearman correlation.ResultsNickel, cobalt, and chromium do not have the same reactivity scores (p < 0.001), and only nickel showed reactive/highly reactive scores. Females were found to have 3.41 times the odds of males for higher Ni reactivity (p = 0.0295, odds ratio [OR], 95% confidence interval [CI] = 3.41 [1.13–10.3]) only. Clinically, there was no correlation between metal SI and OKS score by metal (Ni rho = −0.1779; Co rho = −0.0036; Cr rho = −0.1748).ConclusionThis is the first study looking at MA in well‐functioning TKA. There is no correlation between clinical results and nickel reactivity. Surgeons should exercise caution when revising a painful or poorly functioning TKA based solely on a ‘positive’ Nickel Allergy test and look for other possible reasons for failure.Level of EvidenceLevel II.
Soil priming effect in the organic and mineral layers regulated by nitrogen mining mechanism in a temperate forest
Authors: Chang Qing , Liu Ziping , Zhang Tianyu , Liu Shasha , Liu Bai , Fan Xianlei , Meng Di , Zhang Kun , Bai Edith 
Published: August 2024

AbstractSoil organic carbon (SOC) in temperate forests is a crucial part of the global C cycle. The C and nitrogen (N) inputs may greatly increase in forest ecosystems affected by atmospheric CO2 concentration, N deposition, and other climate change, which may further affect SOC dynamics in temperate forests. Nevertheless, how C and N inputs interact to influence the soil priming effect (PE) in the organic and mineral layers of temperate forests remains unclear. Here, we used easily available C and N sources, such as 13C‐glucose with 2% SOC contents and ammonium nitrate (input C:N ratio = 10), to examine the effects and mechanisms of exogenous C and N inputs on soil CO2 production and PE in both soil layers of a temperate forest. Our research revealed that exogenous C input caused a positive PE in both soil layers, with the mineral layer showing a larger PE per unit of SOC than the organic layer (OL). Although C input increased C loss from native SOC, soil net C accumulation still increased. The C and N inputs decreased the soil PE in both soil layers, suggesting that N input alleviates substrate N limitation and weakens microbial N mining in both soil layers. Meanwhile, the C and N inputs increased the exogenous C remaining in the organic layer, which was beneficial for soil C sequestration. Compared to the organic layer, the response of the mineral layer to C and N inputs was weaker. This study suggests that C and N interact to affect PE on SOC decomposition and this interaction should be considered in modeling and prediction of soil C cycling.
High‐level feature‐guided attention optimized neural network for neonatal lateral ventricular dilatation prediction
Authors: Peng Yulin , Liu Dongmei , Deng Ying , Zhang Meixiang , Yan Lingyu , Luo Yingchun , Yan Junyi 
Published: August 2024

AbstractBackgroundPeriventricular‐intraventricular hemorrhage can lead to posthemorrhagic ventricular dilatation or even posthemorrhagic hydrocephalus if not detected promptly. Sequential cranial ultrasound scans are typically used for their diagnoses. Nonetheless, manual image audit has numerous disadvantages.PurposeThis study aimed to develop a predictive model utilizing modified inception (MI) and high‐level feature‐guided attention (HFA) modules for predicting neonatal lateral ventricular dilation via ultrasound images.MethodsThe MI modules reduced input data sizes and dimensions, while the HFA modules effectively delved into semantic information through supervision from high‐level feature images to low‐level feature images. The process facilitated the accurate identification of dilated lateral ventricles. A total of 710 neonates, corresponding to 1420 lateral ventricles, were recruited in this study. Each lateral ventricle was captured in two images, one on the parasagittal plane and the other on the coronal plane. The combination of anterior horn width, ventricular index, thalamo‐occipital distance, and ventricular height served as the gold standard. A lateral ventricle would be considered dilatated if any of these four indices exceeded its upper reference value. These lateral ventricles were randomly split into training and testing sets at a 7:3 ratio. We evaluated the validity of our proposed approach and its competitors across the coronal plane, parasagittal plane, and overall performance. We also determined the impact of subjects’ baseline characteristics on the overall performance of the proposed approach. Additionally, ablation analyses were conducted to ensure the efficacy of the proposed approach.ResultsOur proposed approach achieved the largest Youden index (0.65, 95% CI: 0.58–0.72), DOR (27.11, 95% CI: 15.89–46.26), area under curves (AUC) of receiver operating characteristic curve (ROC) (0.84, 95% CI: 0.80–0.88), and AUC of precision‐recall curve (PRC) (0.81, 95% CI: 0.74–0.86) in the overall performance assessment and ablation analyses. Moreover, it boasted the biggest Cramer's V values on the coronal (Cramer's V = 0.488, p < 0.001) and parasagittal (Cramer's V = 0.713, p < 0.001) planes individually. Factors such as left side, male sex, singleton birth, and vaginal delivery were positively correlated with higher performance regarding the proposed algorithm, except for the gestational age.ConclusionThis work provides a novel attention optimized algorithm for rapid and accurate ventricular dilatation predictions. It surpasses the traditional algorithms in terms of validity whether concerning the coronal plane, parasagittal plane, or overall performance. The overall performance of algorithms will be influenced by the baseline characteristics of populations.
Treatment‐resistant schizophrenia with 22q11.2 deletion and additional genetic defects
Authors: Furukawa Sawako , Arafuka Shusei , Kato Hidekazu , Ogi Tomoo , Ozaki Norio , Ikeda Masashi , Kushima Itaru 
Published: August 2024

AbstractWe report a case of a 61‐year‐old female with 22q11.2 deletion syndrome (22q11.2DS) and a novel heterozygous nonsense variant in MAP1A, identified through whole‐genome sequencing (WGS). The patient presented with intellectual developmental disorder, treatment‐resistant schizophrenia (SCZ), and multiple congenital anomalies. Despite aggressive pharmacotherapy, she experienced persistent auditory hallucinations and negative symptoms. WGS revealed a 3 Mb deletion at 22q11.2 and a nonsense variant in MAP1A (c.4652T>G, p.Leu1551*). MAP1A, encoding microtubule‐associated protein 1A, is crucial for axon and dendrite development and has been implicated in autism spectrum disorder and SCZ. The MAP1A variant may contribute to the severe psychiatric phenotype, as it is thought to influence synaptic plasticity, a process also affected by 22q11.2 deletion. This case highlights the importance of WGS in identifying additional pathogenic variants that may explain phenotypic variability in 22q11.2DS. Thus, WGS can lead to a better understanding of the genetic architecture of 22q11.2DS. However, further studies are needed to elucidate the role of secondary genetic contributors in the diverse clinical presentations of 22q11.2DS.
Monitoring pediatric CNS non‐germinomatous germ cell tumors via cerebrospinal fluid circulating tumor DNA
Authors: Zhang Yu‐Tong , Jin Xian‐Mei , Zhong Xiao‐Dan , Chang Jian 
Published: August 2024

AbstractBackgroundAccurate molecular and clinical stratification of patients with central nervous system (CNS) non‐germinomatous germ cell tumors (NGGCTs) remains challenging, impeding the development of personalized therapeutic approaches. Herein, we investigated the translational significance of cerebrospinal fluid (CSF) circulating tumor DNA (ctDNA) in pediatric NGGCTs to identify characteristic features of CNS NGGCTs and to identify a subset of patients for whom the presence of residual disease is a risk factor and an indicator of shorter progression‐free survival (PFS) and overall survival (OS).MethodsMedical records of patients with CNS NGGCTs between January 1, 2018 and December 31, 2022 were reviewed retrospectively.ResultsThe cohort consisted of 11 male and six female patients. Tumor markers were elevated in four of the five people who underwent surgery. The remaining 12 patients were diagnosed with malignant NGGCTs according to elevated tumor markers. Among them, ctDNA before chemotherapy as well as ctDNA clearance were consistently associated with PFS and OS (p < .05). By setting a ctDNA positivity threshold of 6%, patients with high ctDNA (above the threshold) levels, which had limitation due to the selection based on optimal statistic from the survival analysis, had significantly inferior 5‐year PFS and OS compared to those with low levels (below the threshold). ctDNA or ctDNA clearance combined with the presence of residual disease predicted significantly worse OS and PFS (p < .05).ConclusionsCSF ctDNA might allow the study of genomic evolution and the characterization of tumors in pediatric NGGCTs. CSF ctDNA analysis may facilitate the clinical management of pediatric NGGCT patients, and aid in designing personalized therapeutic strategies.
Efficient 3D temperature field prediction and visualization for AFP process analysis in composite structures
Authors: Zhang Fengyi , Li Wentao , Li Xiangxi , Yang Di , Qu Weiwei , Ke Yinglin 
Published: August 2024

AbstractProcess modeling is an indispensable tool for establishing a foundation for process optimization and enhancing the quality of products. Analyzing the thermoforming process of polymer matrix composites presupposes the acquisition of accurate thermal histories. This paper introduces a numerical solution based on the finite difference (FD) model to predict the temperature field of angle‐ply composite structures during automated fiber placement (AFP) process along the machining trajectory. The proposed method incorporates three‐dimensional hybrid boundary conditions and considers temperature‐dependent material properties, significantly improving efficiency compared to the finite element (FE) model and overcoming challenges related to complex boundary conditions and anisotropic heat transfer in analytical solutions. Real‐time temperature measurement experiments were conducted to validate predictions, and further a specific temperature control strategy that meets process requirements was explored. In summary, the paper introduces a novel approach to address the temperature field in complex composite structure manufacturing processes.Highlights
A novel 3D finite difference model predicts the temperature field in automated fiber placement.
Improved prediction accuracy by managing complex boundary conditions.
Effectively handled anisotropic heat transfer in complex composite structures.
Superior efficiency over existing numerical methods.
Developed a model‐based strategy for optimal temperature control within ±5°C.
Hydroxyapatite functionalized natural fiber‐reinforced composites: Interfacial modification and additive manufacturing
Authors: Wu Yuxuan , Yang Zhuoyuan , Madiyar Foram , Jiang Yizhou , Namilae Sirish 
Published: August 2024

AbstractNatural fibers are lightweight, cost‐effective, readily available, and eco‐friendly materials. However, natural fiber‐reinforced composites are constrained by biological inconsistency and inferior fiber‐matrix interfacial properties, which restrict effective processing using advanced additive manufacturing methods. In this study, we develop a novel concept for natural fiber composite interfaces by growing hydroxyapatite (HAP) nanocrystals on jute fibers. The resulting hybrid composite is characterized using mechanical testing, nanoindentation, and modulus mapping. The interfacial region suggests a 31.4% increase in stiffness and possesses a storage modulus of up to 7.5 GPa. The tensile modulus and strength of the hybrid composite improves by 30% and 33%, respectively. Furthermore, we develop a novel process for the additive manufacturing of jute fiber thermoset composites through a direct writing (DW) process. The HAP modification increases thermal conductivity, consequently improving the curing process during DW and enhancing composite manufacturability. We demonstrate that the DW process enables the printing of intricate multilayer geometries with varying fiber content.Highlights
Hydroxyapatite is used for natural fiber composite interfacial modification.
Nanoindentation shows the interfacial region exhibits 31.4% higher stiffness.
Modified composites possess superior mechanical performance.
Jute fibers are thermally functionalized for composite additive manufacturing.
A direct writing method is developed for continuous functionalized jute fiber.
Hot melt thermoset/thermoplastic hybrid prepregs: Effects of B‐stage conditions on the quality of composite parts
Authors: Nohair Bendaoud , Dufresne Stéphane , Poirier Daniel , Turgeon Mathieu , Elbouazzaoui Sanaa 
Published: August 2024

AbstractPrepregs are highly expensive, and most customers rely heavily on suppliers. The product may not always be optimized for specific applications, but it is sometimes the only commercially available option that works. To address these issues, there is a need to produce prepregs in‐house. In this article, we will describe the methodology for creating thermoset/thermoplastic hybrid prepregs using hot melt with B‐stage cured epoxy resin film. We investigated the choice of materials and the proportion of thermoplastics through DSC and rheology measurements. Additionally, we analyzed the time and temperature of B‐staging to achieve high‐quality composite parts. Multiple ways for preparing prepregs exists, each involving few different steps. We will explore some of these methods using a hydraulic press before scaling up to a prepreg filmer machine. Our focus will be on evaluating the quality of the final composites under various conditions and comparing them to composites produced with commercially available prepregs.Highlights
In‐house thermoset/thermoplastic hybrid prepreg fabrication optimization procedure.
Material characterization prior to fabrication to ensure B‐staging repeatability.
Investigation of several methods of prepreg fabrication.
Optimized procedure to achieve high‐quality surface finish for composite parts.
Psychological capacity profiles of different age groups and gender in a national representative sample
Authors: Muschalla Beate 
Published: August 2024

AbstractBeyond the specific cognitive capacities like numerical or verbal intelligence and cognitive speed, the so‐called soft skills, namely, psychological capacities, have become highly important in modern life. This is the first representative study on the distribution of work‐relevant psychological capacities in the general population. We investigate capacities in different age groups, gender, and their relation with basic sociodemographics. A representative sample of 2531 people aged 14–95 years was investigated concerning work‐relevant psychological capacities with the mini self‐rating for psychological activities and participation (Mini‐ICF‐APP‐S). The strongest capacities in young people were mobility, flexibility, proactivity, contact to thirds, and group interaction. Other capacities were stronger in midlife (30–59 years), such as adjustment to rules and routines, planning and structuring, decision making and judgement, application of competence and knowledge, assertiveness, dyadic relationships, endurance, and self‐care. Women reported better dyadic relationship capacities, and men felt more assertive. The study provides, for the first time, representative data on a broad range of psychological capacities according to an internationally validated capacity concept. Good psychological capacities occur not primarily in youth, but especially in midlife and older age. Regarding demographic change, this implies older people are highly competent in the working world.
Self‐healing, adhesive, photothermal responsive, stretchable, and strain‐sensitive supramolecular nanocomposite hydrogels based on host–guest interactions
Authors: Chen Shiying , Nie Yixuan , Huang Yingying , Yang Yuxuan , Chen Hongyi , Zhang Xiongzhi 
Published: August 2024

AbstractThe development of multifunctional supramolecular nanocomposite hydrogels remains challenging. Here, the dynamic host–guest interactions involving the host molecule CB[8] and guest units were utilized to prepare Fe3O4 hybrid supramolecular nanocomposite hydrogels. The results showed that the hydrogels obtained possessed a porous structure. The CB[8]‐modified Fe3O4 (Fe3O4@CB[8]) nanoparticles served as cross‐linkers in forming the network of hydrogels. By adjusting the Fe3O4@CB[8] content, the mechanical properties of the hydrogels could be controlled. The tensile stress was measured at 160 kPa with a fracture strain of 1380%, while the compression stress was 230 kPa at 70% compression strain. The self‐healing efficiency of the hydrogels at room temperature reached 95% after 24 h. The as‐obtained hydrogels show strain sensitivity and have the potential for applications in detecting elbow and finger movements. Our supramolecular nanocomposite hydrogels exhibit multiple functions, including self‐healing, injectability, photothermal responsiveness, and conductivity, making them suitable for integration into flexible electronics.Highlights
Fe3O4@CB[8] nanoparticles serve as cross‐linkers for the nanocomposite hydrogels.
CB[8] based host–guest interactions enable hydrogels to self‐heal.
Fe3O4@CB[8] endow hydrogels with stretchability and photothermal responsiveness.
Hydrogels exhibit injectability, NIR responsiveness, and conductive ability.