bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrolysin as an adjuvant therapy after mechanical thrombectomy in large vessel occlusion cardioembolic stroke: a propensity score matching analysis
Authors: ElBassiouny Ahmed , Shehata Mohamed S. A. , Zaki Amr S. , Bedros Rady Y. , El-Sudany Ayman Hassan , Nasser Azza Abdel 
Published: February 2025

IntroductionEndovascular recanalization therapy has demonstrated considerable efficacy in the treatment of acute ischemic stroke (AIS). However, not all patients appear to benefit on the long term from this therapy. No studies have assessed the role of Cerebrolysin following mechanical thrombectomy (MT). The present study was conducted to evaluate the safety and efficacy of Cerebrolysin as add-on treatment to MT in patients with cardioembolic AIS.MethodsThis study evaluated 150 patients admitted to the stroke unit. Data were prospectively collected from 75 patients with cardioembolic AIS and National Institutes of Health Stroke Scale (NIHSS) ≥10, who underwent successful MT ± recombinant tissue plasminogen activator (rt-PA). Patients fulfilling inclusion criteria were consecutively enrolled and treated with Cerebrolysin at a daily dose of 30 ml for 14 days, with treatment initiated within 8 h following MT. Patients were compared with a historical control group of 75 well-matched patients who underwent MT ± rt-PA but did not receive Cerebrolysin. The primary outcome measure was a favorable modified Rankin Scale (mRS = 0–2) at day 90. Secondary parameters included the NIHSS, the Montreal Cognitive Assessment (MoCA), the rate of hemorrhagic transformation, mortality, and adverse events. Propensity score matching was performed to match the variables between the compared groups.Results and discussionThe overall results demonstrated that patients treated with Cerebrolysin exhibited a significantly higher proportion of mRS scores of 0–2 at day 90 (64% vs. 34.7%) in comparison to the control group. This finding was consistent with lower NIHSS and mRS scores at all study visits, and a lower any hemorrhagic transformation rate (20% vs. 57.3%). Furthermore, the logistic regression analysis revealed that patients with favorable mRS scores were less likely to undergo hemorrhagic transformation (odds ratio = 2.75, 95% confidence interval = 1.17, 6.45; p = 0.002). The administration of Cerebrolysin as an add-on treatment resulted in a significant benefit for AIS patients following MT, characterized by an improvement in mRS and NIHSS scores, along with a reduced rate of hemorrhagic transformation. The administration of Cerebrolysin was safe and well tolerated. Further studies are required to confirm these results.
Unveiling the effects of Rosa canina oligosaccharide liposome on neuropathic pain and motor dysfunction following spinal cord injury in rats: relevance to its antioxidative effects
Authors: Ahmadpour Yasaman , Bahrami Gholamreza , Arkan Elham , Abbaszadeh Fatemeh , Aghaz Faranak , Fakhri Sajad , Echeverría Javier 
Published: February 2025

BackgroundSpinal cord injury (SCI) is a leading cause of sensorimotor disorders, impacting millions of people globally. The absence of effective treatments and the side effects of existing medications highlight the need for innovative research into new therapeutic compounds.PurposeGiven the critical role of oxidative stress in the development of SCI and the antioxidant properties of oligosaccharides in other neurological disorders, this study focuses on the role of oxidative stress in SCI and explores the potential of a novel oligosaccharide nanoformulation derived from Rosa canina (Oligo-L).Materials and methodsOligo-L was formulated using soy lecithin as the phospholipid and the characterization included size, zeta potential, morphology, and drug loading efficiency. Then 35 Wistar male rats were divided into five groups of Sham, SCI, and Oligo-L (10 μL intrathecal injection of 15, 30, and 45 mg/mL). An aneurysm clip was used to induce compression injury of the SCI and Oligo-L groups. Sensory-motor functions were evaluated weekly for 4 weeks using tests such as the BBB scale, inclined plane, acetone drop, hot plate, von Frey, and monitoring of weight changes. Additionally, oxidative stress markers and histological changes were examined to evaluate changes in nitrite, glutathione, catalase, and neuronal survival.Results and discussionThe findings indicated that Oligo-L treatment led to significant improvements in neuropathic pain, and motor function performance and weight of the animals from the first week post-SCI. Oligo-L also enhanced catalase and glutathione levels while reducing serum nitrite levels, contributing to neuronal preservation. Additionally, Oligo-L increased neuronal survival in the both ventral (motor neurons) and dorsal (sensory neurons) horns of the spinal cord.ConclusionOverall, Oligo-L, characterized by its beneficial physicochemical properties, showed promising potential as a neuroprotective agent and facilitated the recovery of sensory and motor functions after SCI.
The association between the lifestyle risk score and metabolically healthy and unhealthy obesity phenotype in Iranian women with overweight and obesity: a cross-sectional study
Authors: Ebrahimi Sara , Shiraseb Farideh , Ladaninezhad Maryam , Izadi Azimeh , Navaei Negin , Mirzaei Khadijeh 
Published: February 2025

BackgroundThe evidence shows that all women with obesity do not develop metabolic complications thus, they may be metabolically healthy. The lifestyle factors in combination may influence obesity phenotypes including metabolically healthy and unhealthy obesity. While previous studies examined associations between single lifestyle factors and obesity phenotype, no previous study has examined associations between lifestyle risk score (LRS) and obesity phenotypes. This study for the first time created the LRS which is a combination of lifestyle factors and investigated the LRS in relation to various obesity phenotypes among women with overweight and obesity.MethodsThis cross-sectional study analyzed 278 women referred to health centers of the Tehran University of Medical Sciences. A multistage sampling method was used to recruit the participants. The LRS was created based on diet, physical activity (PA), sleep, obesity, and sociodemographic characteristics. A binary logistic regression analysis was used to evaluate the association between obesity phenotypes and LRS.ResultsWomen with higher LRS had higher body mass index (BMI) and high-sensitivity C-reactive protein (hs-CRP) while had lower high-density lipoprotein cholesterol (HDL-C), PA, education levels, sleep quality, vegetables, grains and legumes intake. Furthermore, women with higher LRS were more likely to experience metabolically unhealthy obesity (MUO).ConclusionThis study found significant associations between higher LRS and an increased likelihood of MUO. Further prospective studies are needed to advance our understanding of the relationship between lifestyle and obesity.
Prophylactic Treatment of Hepatitis C Virus Infection After Kidney Transplantation with the Combination of Glecaprevir/Pibrentasvir and Sofosbuvir in a Highly Sensitized Hepatitis C Virus-Negative Recipient: A Case Report and Review of the Literature
Authors: Belčič Mikič Tanja , Sterle Igor , Matičič Mojca , Arnol Miha 
Published: February 2025

Background: Since the discovery of successful direct-acting antiviral (DAA) treatment, kidneys from hepatitis C virus (HCV) RNA-positive donors represent a new opportunity to expand the organ donor pool for HCV-negative recipients. Case presentation: In this paper, we describe a unique case of transplantation of an HCV genotype 3a-infected kidney into an HCV-negative recipient who was highly sensitized, with a virtual panel-reactive antibody level of 99.96%. Prior to the kidney transplantation, the recipient received DAA treatment with glecaprevir/pibrentasvir as a viable prophylactic strategy. Post-transplant, the recipient received a triple-combination DAA regimen with glecaprevir/pibrentasvir/sofosbuvir, which continued for 12 weeks. Subsequently, viral load was undetectable at 12 and 24 weeks after treatment, with no significant adverse events associated with DAA therapy. A 12-month post-transplantation biopsy revealed mixed rejection requiring treatment. The 19-month follow-up showed a favorable outcome regarding the function of the kidney allograft and the recipient’s quality of life. HCV-positive transplantation allowed our recipient to receive a kidney from an immunologically compatible donor without donor-specific antibodies and the need for desensitization strategies. Conclusions: Each transplant center should decide on the selection of candidates for kidney transplantation from HCV RNA-positive donors to HCV-negative recipients, the availability and choice of DAA treatment, and post-transplant follow-up. Our case emphasizes the need for early DAA treatment based on viral load and HCV genotyping, as well as for careful post-transplant surveillance including protocol biopsies.
Genetic Diversity of the Traditional Economic Green Alga Capsosiphon fulvescens in Republic of Korea
Authors: Lee Soon Jeong , Lee Eun-Young , Lee Sang-Rae 
Published: February 2025

The taxonomic position of the green alga Capsosiphon fulvescens was first reported from Northern Europe and has since been reported from all over the world, including Korea. In Korea, C. fulvescens has been used as an essential edible economic alga for approximately 570 years, from the time of the Joseon Dynasty to the present, and is currently under development as a new aquaculture strain. Therefore, examining the taxonomic relationships between the European and Korean C. fulvescens is important. In this study, we analyzed nuclear 18S rDNA and ITS regions and compared them with the DNA sequences of authentic materials of North Atlantic C. fulvescens. Additionally, rbcL and tufA genes were sequenced to analyze genetic variations among populations. The results showed that the Korean and European C. fulvescens were different species. Moreover, the Korean C. fulvescens was distantly related to the North Atlantic C. fulvescens at the order level. Moreover, the Korean C. fulvescens formed a sister group with the North Pacific Pseudothrix borealis. Cryptic genetic diversity was observed at the intraspecific level among the Korean populations. These findings will help in tracing the origin of the Korean C. fulvescens and provide new genetic insights into this species.
Resolving the Open Problem by Proving a Conjecture on the Inverse Mostar Index for c-Cyclic Graphs
Authors: Alex Liju , Das Kinkar Chandra 
Published: February 2025

Inverse topological index problems involve determining whether a graph exists with a given integer as its topological index. One such index, the Mostar index, Mo(G), is defined as Mo(G)=∑uv∈E(G)|nu(e|G)−nv(e|G)|, where nu(e|G) and nv(e|G) represent the number of vertices closer to vertex u than v and closer to v than u, respectively, for an edge e=uv. The inverse Mostar index problem has gained significant attention recently. In their work, Alizadeh et al. [Solving the Mostar index inverse problem, J. Math. Chem. 62 (5) (2024) 1079–1093] proposed the following open problem: “Which nonnegative integers can be realized as Mostar indices of c-cyclic graphs, for a given positive integer c?”. Subsequently, one of the present authors [On the inverse Mostar index problem for molecular graphs, Trans. Comb. 14 (1) (2024) 65–77] conjectured that, except for finitely many positive integers, all other positive integers can be realized as the Mostar index of a c-cyclic graph, where c≥3. In this paper, we address the inverse Mostar index problem for c-cyclic graphs. Specifically, we construct infinitely many families of symmetric c-cyclic structures, thereby demonstrating a solution to the inverse Mostar index problem using an infinite family of such symmetric structures. By providing a comprehensive proof of the conjecture, we fully resolve this longstanding open problem.
Second (2nd) Trimester Kidney Function and Adverse Pregnancy Outcomes among Patients with Lupus
Authors: Lucas Anika M. , Miller Cameron , Eudy Amanda , Myers Rachel , Wyatt Christina M. , Wheeler Sarahn , Petri Michelle , Fischer-Betz Rebecca , Mokbel Abir , Nalli Cecilia , Andreoli Laura , Tincani Angela , Molad Yair , Balevic Stephen , Gladman Dafna D. , Urowitz Murray , Clowse Megan E.B. 
Published: February 2025

Background:
Kidney function is not routinely assessed during pregnancy. Several studies have proposed antepartum kidney function, particularly 2nd trimester kidney function, as a potential predictor of adverse pregnancy outcomes. It has been previously established that patients with Systemic Lupus Erythematosus are at increased risk for adverse pregnancy outcomes. The association between 2nd trimester kidney function and adverse pregnancy outcomes has not been evaluated in diverse patient populations, particularly among patients with high obstetrical risk.

Methods:
In this observational study of pregnant patients with lupus in North America and Europe from 1995-2017, we used 2nd trimester creatinine and the estimated glomerular filtration rate (eGFR) to model the log odds of preeclampsia, preterm birth, low birthweight, fetal loss, and a composite of those outcomes. We incorporated these measures into a regression setting using fractional polynomials, and we further examined discrete formulations of eGFR.

Results:
Among 684 pregnancies in patients with lupus, the mean 2nd trimester creatinine was 0.63mg/dL ± SD 0.26 and the median value 0.60 (IQR 0.50-0.70). At least 1 in 3 patients in this combined cohort experienced an adverse outcome. Mixtures of U-shaped and linear relationships between continuous kidney function and the log odds of adverse pregnancy outcomes were observed. Stratifying the cohort by diagnosis of lupus nephritis (active or in remission) or without diagnosis of nephritis, we found differences in the relationship between kidney function and adverse outcomes.

Conclusions:
We observed high rates of adverse pregnancy outcomes in our diverse patient population comprised of pregnant patients with lupus with and without lupus nephritis. We identified complex relationships between 2nd trimester kidney function and adverse pregnancy outcomes that differed by the outcome and diagnosis of lupus nephritis.
Sex and Cause-Specific Mortality among US Adults Receiving Maintenance Dialysis
Authors: Abi Nanzha , Rossi Ana , Pastan Stephen O. , Patzer Rachel E. , Harding Jessica L. 
Published: February 2025

Background:
We examined sex differences in cause-specific mortality among men and women receiving maintenance dialysis and examined potential effect modification by age and race.

Methods:
We identified all adults aged ≥ 18 years initiating dialysis between 2000 and 2020 from the United States Renal Data System (n=2.16 million; 43.3% women). Cause-specific mortality (i.e., cardiovascular (CVD), withdrawal, infection, cancer) was defined from the Centers for Medicare and Medicaid Death Notification Form. All individuals were followed from dialysis start date until death date, transplant, 10-years, or end of follow-up (December 31, 2021), whichever occurred first. Multivariable Cox proportional hazards models assessed the association between sex and 10-year cause-specific mortality, adjusting for demographic, clinical, and socioeconomic factors overall and stratified by age and race.

Results:
Overall, 832,259 men (67.9%) and 658,043 women (70.4%) died receiving maintenance dialysis with median survival times of 2.69 (IQR,1.17-5.19) and 2.72 (IQR, 1.16-5.21) years, respectively. CVD was the leading cause of death (38.6% women; 40.2% men), followed by withdrawal (11.1% women; 9.6% men) and infections (9.8% women; 8.6% men). Overall, women had a 9% (adjusted Hazard Ratio: 1.09 [95%CI 1.08-1.11]) and 15% (1.15 [1.14-1.17]) higher likelihood of infection, and withdrawal -related mortality compared with men, respectively. Conversely, women had a 7% (0.93 [0.92-0.94]) and 10% (0.90 [0.87-0.92]) lower likelihood of CVD and cancer-related mortality, respectively, compared with men. By age, younger women (vs. men) aged 18-44 years had higher likelihood of excess mortality across all specific causes (including a 40% increased risk of withdrawal compared to men of the same age), while older women (vs. men) aged >75 years had a lower likelihood. By race, non-Hispanic Black women (vs. men) had higher mortality across all specific causes, but for all other races, sex differences were similar to the overall population.

Conclusions:
A sex-specific approach that incorporates intersectionality of both age and race in the management of complications among dialysis patients may be recommended to mitigate excess mortality risks.
The Methylene Blue Adsorption by Calcium Alginate-Activated Carbon Composite in Fixed Bed Column
Authors: Wardana Putra Adzikri , Hermawan Heru , Setyaningrum Sinta , Paramitha Tifa 
Published: February 2025

Methylene blue is a material that is often used as a cationic dye in the textile industry. Methylene blue is toxic and difficult to degrade. Adsorption is one method to reduce the methylene blue from wastewater. In this study, methylene blue was adsorbed by calcium alginate/activated carbon composite (CaAlg-AcC) in a fixed bed column. The influence of CaCl2.2H2O concentration, initial concentration of methylene blue, and flow rate in the continuous adsorption process were investigated. Every adsorption process was done in 110 min. The results revealed that the CaAlg-AcC composite synthesized using 1% (w/v) CaCl2.2H2O solution has the highest adsorption percentage, 95.28% in 110 min. The initial methylene blue concentration 50 mg/L gave the highest result of adsorption percentage with the smallest amount of methylene blue adsorbed of 31.77 mg. The flow rate of methylene blue 4 ml/min reached the highest adsorption percentage with the amount of methylene blue adsorbed of 41.79 mg.
Basic study on the effects of fat deposition in rat livers on relationship between acoustic and electrical properties
Authors: Nagaoka Miyu , Ito Koichi , Hirata Shinnosuke , YOSHIDA Kenji , YAMAGUCHI Tadashi 
Published: February 2025

Abstract
We conducted a fundamental study to elucidate the relationship between acoustic and electrical properties in the context of liver steatosis. The speed of sound, attenuation coefficient, conductivity, and relative permittivity were measured in rat livers with varying degrees of fat deposition. Fat deposition result in a decrease in the speed of sound, an increase in the attenuation coefficient, and reductions in conductivity and relative permittivity. However, no linear correlation was observed between these properties and fat content or droplet size individually. However, a notable correlation between changes in acoustic and electrical properties was identified when the structural and organizational effects of fat were considered in combination. Especially, attenuation changes were found to correlate with corresponding changes in electrical properties. These findings underscore the importance of comprehensively considering structural factors, such as fat droplet size and distribution, to better understand the physical mechanisms underlying the relationship between acoustic and electrical properties.
Роль командної роботи у забезпеченні успішного виконання навчальних проєктів студентами ІТ-спеціальностей
Authors: Povstiana Yu. , Hulchuk Yu. , Povstiana S. 
Published: February 2025

У статті досліджується роль командної роботи в контексті навчальних проєктів ІТ-спеціальностей. На основі проведеного аналізу сформульовано висновки щодо важливості розвитку навичок командної роботи у сучасних ІТ-фахівців та перспектив використання інноваційних технологій в освітньому процесі. У статті детально аналізуються переваги та виклики, пов’язані з командною взаємодією серед студентів. Зокрема, підкреслюється роль командної роботи у розвитку м’яких навичок, розширенні знань та підготовці до професійної діяльності. Однак, робота також висвітлює потенційні труднощі, такі як конфлікти, нерівномірний розподіл роботи та проблеми з комунікацією. Для мінімізації цих ризиків пропонуються ефективні стратегії, включаючи чітке визначення ролей, регулярні зустрічі команди та розвиток лідерських якостей. Особлива увага приділяється ролі сучасних технологій у покращенні командної роботи. Розкрито можливості використання онлайн-платформ та штучного інтелекту для підвищення ефективності співпраці, автоматизації рутинних завдань та аналізу даних. Серед технічних ресурсів, які забезпечують ефективну командну роботу визначено: Asana, Trello, Monday.com, Slack, Microsoft Teams, Coursera, Udemy, Teamwork, Wrike, Miro, Crello, Canva. Представлені засоби управління командною роботу сприятимуть налагодженню подальшої ефективної комунікації з усіма учасниками реалізації навчальних проєктів. На підставі проведеного аналізу формулюються висновки щодо важливості командної роботи в освітньому процесі та перспектив використання інноваційних технологій для її вдосконалення. Стаття буде корисною для викладачів, студентів, а також для фахівців, які займаються розробкою навчальних програм в галузі інформаційних технологій.
Gaze cues facilitate incidental learning in children aged 7–10 years, but arrow cues do not
Authors: Ishikawa Mitsuhiko , Yoshioka Ayumi 
Published: February 2025

Abstract
From infancy, humans use gaze cues from others to learn about their surrounding environment. It is known that gaze cues facilitate the cognitive processing of targets in both infants and adults, but what developmental changes occur during childhood? This study investigated the impact of gaze cueing on incidental learning in children aged 7–10 years (n = 80). Participants completed a cueing task where they were presented with gaze or arrow cues (valid or invalid) followed by a target stimulus. Then, participants conducted an incidental memory test including the target stimuli presented in the cueing task and novel stimuli. Results revealed that valid gaze cues significantly enhanced memory performance compared to arrow cues, while gaze cues and arrow cues had similar effects on attention orienting. This effect was consistent across age groups, suggesting that gaze cueing facilitates memory regardless of developmental stage. The findings support the socio-communicative aspect of gaze cues, which may influence cognitive facilitation in joint attentional situations in childhood. Joint attentional situations may be rewarding, influencing the motivation for implicit cognitive processing of objects that are the focus of attention. This study contributes to our understanding of spontaneous social cognition in children and underscores the importance of gaze cues in facilitating memory and learning in social contexts.