bluuebunny/crossref_metadata_2025_split huggingface dataset:
Le château de Villesavin
Authors: Ponsot Patrick 
Published: September 2015

Le château de Villesavin.
Un relevé complet des bâtiments, l'étude exhaustive des documents conservés permettent de ressituer le château de Villesavin à sa place de « monument d'avant-garde ».
Il a été construit de 1526 à 1537 pour Jean Breton, notaire et secrétaire du roi François Ier. Contrairement à ce qu'affirme une tradition erronée, l'ensemble des bâtiments remonte au XVIe siècle, ainsi que l'organisation en trois cours. Les modèles doivent être cherchés en Italie, dans ces grosses villas campagnardes organisées comme de petites villes, qui seront ensuite popularisées en France par Serlio. Le décor originel et les jardins peuvent être restitués grâce à quelques vestiges. Ils permettent d'imaginer le luxe dont aimaient s'entourer les financiers de l'entourage de François Ier.
Par ailleurs, le château a été embelli en 1822 dans le style troubadour. Ce serait l'une des premières manifestations qui ne soit ni éphémère, ni jardinière. Ce témoignage est replacé dans le contexte de l'époque.
L'ancienne église Notre-Dame de Poligny : un jalon dans l'histoire de l'architecture gothique du XIIIe siècle en Franche-Comté
Authors: Sauvage Isabelle 
Published: September 2015

L'ancienne église Notre-Dame de Poligny : un jalon dans l'histoire de l'architecture gothique du XIIIe siècle en Franche-Comté, par Isabelle Sauvage.
L'ancienne église Notre-Dame de Poligny a été construite entre les années 1240 et 1270 à l'instigation des princes Othon III et Alix de Méranie. D'abord prévue pour être une collégiale, elle fut donnée en 1271 aux Dominicains. La construction évolua de façon régulière d'est en ouest, mais probablement avec une courte interruption du chantier vers le milieu du siècle. Traditions régionales et influences françaises s'y combinent. Par un plan simplifié à trois vaisseaux de cinq travées et un chevet polygonal, une nef peu élevée et un éclairage restreint, d'une part ; par une élévation à trois niveaux : grandes arcades, triforium et fenêtres hautes, des piles cantonnées de type chartrain, un faisceau de trois colonnettes recevant les nervures de la voûte, rares en Franche-Comté, d'autre part.
François Mansart à Toulouse
Authors: Costa Georges 
Published: September 2015

François Mansart à Toulouse, par Georges Costa.
En 1614, un arrêt du Conseil du Roi décida que le pont neuf de Toulouse serait achevé suivant les plans de Jacques Lemercier. Parmi les entrepreneurs adjudicataires des travaux figurait Marcel Le Roy qui donna, le 1er juillet 1618 à Toulouse, procuration à son neveu François Mansart pour le remplacer sur le chantier du pont alors en construction. A ce titre, le jeune Mansart eut pour tâche de conduire, avec ses associés, l'exécution de l'ouvrage. Son rôle, avec Jacques Boullet, fut mis en évidence lors de la découverte de la fente de la cinquième pile en février 1619, puis lors de l'affaire de la démolition de l'arche construite jadis par Pierre Souffron, le précédent maître d'œuvre. Les conflits locaux suscités par cette démolition entraînèrent l'interruption du chantier, et le départ de François Mansart de Toulouse en janvier 1621. On peut considérer ce long séjour toulousain comme l'achèvement pratique de la formation professionnelle de François Mansart.
Les caractères généraux de la démographie de Valenciennes au XIXe siècle
Authors: Barbier Frédéric 
Published: September 2015

L'étude de la démographie valenciennoise entre 1800 et le début du XXe siècle met en évidence la spécificité de son évolution : taux de natalité élevés, taux de mortalité également supérieurs à la moyenne nationale, mais nuptialité très basse. Le modèle démographique valenciennois apparaît ainsi comme relativement archaïque.
Dans l'ensemble, la population augmente modérément, la surcharge démographique liée à l'industrialisation se portant surtout sur les communes périphériques, et l'augmentation observée dans la ville même résulte avant tout d'une immigration de provenance régionale. De ce fait, la pyramide des âges y est caractérisée par le poids relativement élevé des éléments jeunes.
Dans le dernier quart du xixe siècle, cette spécificité valenciennoise s'atténue cependant rapidement, avec la quasi disparition des crises périodiques de surmortalité, et le rapprochement des taux démographiques urbains des moyennes nationales.
Il faut souligner l'évolution particulière de l'illégitimité, dont les taux restent très élevés, malgré une tendance à la baisse, tout au long du xixe siècle ; on peut mettre ce phénomène en rapport avec la présence d'une garnison importante dans la ville, et le rôle que joue cette dernière comme pôle d'un « plat pays » à la population très dense.
Serions-nous les chiens de Pavlov ?
Authors: De Visscher Héloïse 
Published: September 2015

L’article paru dans le n o 105 des C.I.P.S. « Le sens critique et quoi encore ? » mettait l’accent sur l’importance d’adopter une attitude critique à l’égard des informations qui nous parviennent tous azimuts. La dite réflexion est poursuivie plus spécifiquement au départ d’une question : « sommes-nous manipulés, soumis, englués dans un monde d’influence et de pression sans aucun recours ou contrôle sur nos perceptions et nos actions ? ». Un exercice structuré « Les deux font la paire » amène à s’interroger sur la pertinence d’effectuer une tâche, associer symboles (logos) et affirmations (phrases), sans la questionner.
A Gene Expression Signature That Correlates with CD8+ T Cell Expansion in Acute EBV Infection
Authors: Greenough Thomas C. , Straubhaar Juerg R. , Kamga Larisa , Weiss Eric R. , Brody Robin M. , McManus Margaret M. , Lambrecht Linda K. , Somasundaran Mohan , Luzuriaga Katherine F. 
Published: September 2015

Abstract
Virus-specific CD8+ T cells expand dramatically during acute EBV infection, and their persistence is important for lifelong control of EBV-related disease. To better define the generation and maintenance of these effective CD8+ T cell responses, we used microarrays to characterize gene expression in total and EBV-specific CD8+ T cells isolated from the peripheral blood of 10 individuals followed from acute infectious mononucleosis (AIM) into convalescence (CONV). In total CD8+ T cells, differential expression of genes in AIM and CONV was most pronounced among those encoding proteins important in T cell activation/differentiation, cell division/metabolism, chemokines/cytokines and receptors, signaling and transcription factors (TF), immune effector functions, and negative regulators. Within these categories, we identified 28 genes that correlated with CD8+ T cell expansion in response to an acute EBV infection. In EBV-specific CD8+ T cells, we identified 33 genes that were differentially expressed in AIM and CONV. Two important TF, T-bet and eomesodermin, were upregulated and maintained at similar levels in both AIM and CONV; in contrast, protein expression declined from AIM to CONV. Expression of these TF varied among cells with different epitope specificities. Collectively, gene and protein expression patterns suggest that a large proportion, if not a majority of CD8+ T cells in AIM are virus specific, activated, dividing, and primed to exert effector activities. High expression of T-bet and eomesodermin may help to maintain effector mechanisms in activated cells and to enable proliferation and transition to earlier differentiation states in CONV.
ATF3 Is a Key Regulator of Macrophage IFN Responses
Authors: Labzin Larisa I. , Schmidt Susanne V. , Masters Seth L. , Beyer Marc , Krebs Wolfgang , Klee Kathrin , Stahl Rainer , Lütjohann Dieter , Schultze Joachim L. , Latz Eicke , De Nardo Dominic 
Published: September 2015

Abstract
Cytokines and IFNs downstream of innate immune pathways are critical for mounting an appropriate immune response to microbial infection. However, the expression of these inflammatory mediators is tightly regulated, as uncontrolled production can result in tissue damage and lead to chronic inflammatory conditions and autoimmune diseases. Activating transcription factor 3 (ATF3) is an important transcriptional modulator that limits the inflammatory response by controlling the expression of a number of cytokines and chemokines. However, its role in modulating IFN responses remains poorly defined. In this study, we demonstrate that ATF3 expression in macrophages is necessary for governing basal IFN-β expression, as well as the magnitude of IFN-β cytokine production following activation of innate immune receptors. We found that ATF3 acted as a transcriptional repressor and regulated IFN-β via direct binding to a previously unidentified specific regulatory site distal to the Ifnb1 promoter. Additionally, we observed that ATF3 itself is a type I IFN–inducible gene, and that ATF3 further modulates the expression of a subset of inflammatory genes downstream of IFN signaling, suggesting it constitutes a key component of an IFN negative feedback loop. Consistent with this, macrophages deficient in Atf3 showed enhanced viral clearance in lymphocytic choriomeningitis virus and vesicular stomatitis virus infection models. Our study therefore demonstrates an important role for ATF3 in modulating IFN responses in macrophages by controlling basal and inducible levels of IFNβ, as well as the expression of genes downstream of IFN signaling.
Cutting Edge: CTLA-4Ig Inhibits Memory B Cell Responses and Promotes Allograft Survival in Sensitized Recipients
Authors: Chen Jianjun , Wang Qiang , Yin Dengping , Vu Vinh , Sciammas Roger , Chong Anita S. 
Published: September 2015

Abstract
Sensitized recipients with pretransplant donor-specific Abs are at higher risk for Ab-mediated rejection than nonsensitized recipients, yet little is known about the properties of memory B cells that are central to the recall alloantibody responses. Using cell enrichment and MHC class I tetramers, C57BL/6 mice sensitized with BALB/c splenocytes were shown to harbor H-2Kd–specific IgG+ memory B cells with a post–germinal center phenotype (CD73+CD273+CD38hiCD138−GL7−). These memory B cells adoptively transferred into naive mice without memory T cells recapitulated class-switched recall alloantibody responses. During recall, memory H-2Kd–specific B cells preferentially differentiated into Ab-secreting cells, whereas in the primary response, H-2Kd–specific B cells differentiated into germinal center cells. Finally, our studies revealed that, despite fundamental differences in alloreactive B cell fates in sensitized versus naive recipients, CTLA-4Ig was unexpectedly effective at constraining B cell responses and heart allograft rejection in sensitized recipients.
Protein Tyrosine Phosphatase SHP-1 Modulates T Cell Responses by Controlling Cbl-b Degradation
Authors: Xiao Yun , Qiao Guilin , Tang Juan , Tang Rong , Guo Hui , Warwar Samantha , Langdon Wallace Y. , Tao Lijian , Zhang Jian 
Published: September 2015

Abstract
Previously, we demonstrated that CD28 and CTLA-4 signaling control Casitas-B-lineage lymphoma (Cbl)-b protein expression, which is critical for T cell activation and tolerance induction. However, the molecular mechanism(s) of this regulation remains to be elucidated. In this study, we found that Cbl-b fails to undergo tyrosine phosphorylation upon CD3 stimulation because SHP-1 is recruited to and dephosphorylates Cbl-b, whereas CD28 costimulation abrogates this interaction. In support of this finding, T cells lacking SHP-1 display heightened tyrosine phosphorylation and ubiquitination of Cbl-b upon TCR stimulation, which correlates with decreased levels of Cbl-b protein. The aberrant Th2 phenotype observed in T cell–specific Shp1−/− mice is reminiscent of heightened Th2 response in Cblb−/− mice. Indeed, overexpressing Cbl-b in T cell–specific Shp1−/− T cells not only inhibits heightened Th2 differentiation in vitro, but also Th2 responses and allergic airway inflammation in vivo. Therefore, SHP-1 regulates Cbl-b–mediated T cell responses by controlling its tyrosine phosphorylation and ubiquitination.
Emergency Obstetric Hysterectomies at a Tertiary Referral Shri Vasantrao Naik Government Medical College and Hospital of Tribal of Yavatmal District (Maharashtra): Retrospective Critical Analysis (6 Years Study)
Authors: Rathod Archana D , Pajai Sandhya P 
Published: September 2015

ABSTRACT

Objective
To evaluate the demographic profile, high-risk factors, fetomaternal outcome, causes and incidence of emergency peripartum hysterectomies at tertiary referral center Government Medical College and Hospital at Yavatmal.

Study design
Retrospective analysis.

Methodology
Review of 14 case records of patient who undergone emergency peripartum hysterectomies during the year January 2007 to December 2012.

Results
During the study period, there were 39,612 deliveries, out of which 14 patients had undergone emergency peripartum hysterectomy (EPH), having an incidence of 0.35/1000 births. There was 1 (7.14%) maternal death and 5 (35.71%) perinatal deaths. The commonest indications noted were atonic PPH 7 (50%), morbidly adherent placenta 5 (35.71%) and rupture uterus 2 (14.28%).
Five (35.71%) of these patients had not received antenatal care prior to their hospitalization.
Lack of antenatal care and health education indeed a preventable factor that needs to be addressed to reduce maternal and fetal mortality and morbidity.
Identification of high-risk patients, institutional deliveries by expert of risk group and early referral from peripheral health infrastructures are utmost importance in avoiding EPH and reduce maternal and fetal morbidity and mortality.
Emergency obstetric hysterectomy still remains as life saving procedure which every obstetrician must be familiar with it.

How to cite this article
Rathod AD, Pajai SP. Emergency Obstetric Hysterectomies at a Tertiary Referral Shri Vasantrao Naik Government Medical College and Hospital of Tribal of Yavatmal District (Maharashtra): Retrospective Critical Analysis (6 Years Study). J South Asian Feder Obst Gynae 2015;7(2): 55-60.
Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors
Authors: Pilli Ganga S , Patil Prakash V , Karadesai SG 
Published: September 2015

ABSTRACT

Aim
To determine if osteopontin expression by immunohistochemistry (IHC) can correlate with histological type and grade of epithelial ovarian cancer.

Materials and methods
The present work has been carried out at department of pathology, of a reputed medical college in Belgaum district of Karnataka state. The study is carried out for a period of 18 months for data collection, evaluation of the marker and data analysis. All consecutive specimens of ovarian tumors are included in the study. The study included 55 epithelial ovarian tumors and these are analyzed histopathologically. In all the cases, osteopontin expression has been studied with IHC on paraffin slides.

Results
This study included 41 (74.5%) benign tumors and 14 (25.5%) malignant tumors. High grade (grade III) was common in serous carcinomas than in other histological types. Fisher's exact test p-value < 0.001 was significant for expression of osteopontin and all the malignant ovarian epithelial tumors expressed osteopontin by IHC procedure on paraffin tissue sections. All high-grade epithelial ovarian tumors showed increased expression of osteopontin of +++ and low-grade tumors expressed +/++osteopontin.

Conclusion
The osteopontin expression was seen in all the malignant epithelial ovarian cancers and the osteopontin expression was significantly higher in high-grade epithelial ovarian cancers than low-grade epithelial ovarian cancers.

How to cite this article
Pilli GS, Patil PV, Karadesai SG. Osteopontin as a Prognostic Indicator in Grading of Ovarian Epithelial Tumors. J South Asian Feder Obst Gynae 2015;7(2): 61-63.
Novel Possibilities for the Diagnosis of Fetal Distress in Pre-eclamptic Women
Authors: Lakhno Igor Victorovich 
Published: September 2015

ABSTRACTObjectiveFetal deterioration has been known as a result of acute or chronic disturbances in the system of ‘motherplacenta- fetus’. Pre-eclampsia (PE) is a maternal gestational disease caused by abnormal placentation that could provoke fetal distress.AimThe aim of the investigation was to survey the accuracy of fetal distress diagnostics in case of traditional cardiotocography (CTG) waveform evaluation and electrocardiography (ECG) parameters analysis obtained from maternal abdominal signal before and during labor in pre-eclamptic patients.Materials and methodsOne hundred and thirty-nine pregnant ladies at 32 to 40 weeks of gestation were enrolled in the study. There were 30 women with physiological pregnancy and normal fetal condition according to hemodynamic Doppler values and fetal ECG parameters in group I. In group II, 64 patients with mild and moderate PE were involved whom were performed fetal ECG noninvasive monitoring and hemodynamic Doppler. In group III, 45 patients with severe PE were monitored with fetal noninvasive ECG and hemodynamic Doppler.ResultsIt was determined that fetal autonomic tone was suppressed with the relative increase of low frequency branch in pre-eclamptic patients. The increased value of the amplitude of mode and stress index was associated with abnormal myocardial adrenergic stimulation. It has induced pQ and QT shortening, increased T/QRS ratio. Fetal cardiac response was determined as gradual reduce of autonomic regulation.The most considerable negative correlation was determined in pair Apgar score 1 vs T/QRS (R = – 0.48; p < 0.05). The QT interval duration has revealed positive correlation with Apgar score 1 (R = 0.44; p < 0.05). Additional to the conventional CTG analysis evaluation of noninvasive fetal ECG parameters has contributed to better diagnostic of distress.ConclusionFetal noninvasive ECG has showed sensitivity 100.0% and specificity 93.8% and, therefore, was more accurate and convenient method for fetal monitoring than conventional CTG.How to cite this articleLakhno IV. Novel Possibilities for the Diagnosis of Fetal Distress in Pre-eclamptic Women. Int J Infertil Fetal Med 2015;6(2):62-66.
The Detection of BANA Hydrolysis Activity in Abutment Teeth in Patients with Removable Partial Denture
Authors: Kalaria Jigar P , Patel Birood G , Agrawal Charu 
Published: September 2015

ABSTRACT

Purpose
The aim of this study was to detect the presence of N-benzyl-Dl-arginase-2-naphthalamide (BANA) micro- organisms in chronic periodontitis of abutment teeth in subjects wearing removable partial dentures (RPDs) by measuring the red complex using BANA-ZymeTM test.

Materials and methods
Twenty-five subjects (mean age: 59.3 years) with Kennedy class II partially edentulous arch participated in this study. The microbiological record of red complex was done by BANA-Zyme kit and clinical parameters, such as plaque index (PI), gingival index (GI) and probing depth were recorded at abutment teeth in contact with the direct retainer of unilaterally designed RPDs and the corresponding nonabutment teeth on the opposite side.

Results
Mean scores of BANA for the red complex, PI and GI of the abutment teeth were significantly greater than those of the nonabutment teeth (p < 0.01). No significant mean difference in pocket depth (PD) was found between the abutment and nonabutment teeth. Logistic regression analysis revealed that abutment teeth, high scores of PI and a maintenance interval longer than 6 months were significant predictors for positive red complex scores (p < 0.05).

Conclusion
These results suggest that the microbiological risk for periodontitis of abutment teeth is greater than that for nonabutment teeth in RPD wearers.

How to cite this article
Kalaria JP, Patel BG, Patel V, Agrawal C. The Detection of BANA Hydrolysis Activity in Abutment Teeth in Patients with Removable Partial Denture. Int J Prosthodont Restor Dent 2015;5(2):31-37
A Spectrophotometric Analysis of Color Changes in Metal Ceramic Restorations by Varying Porcelain Thickness and Repeated Firings: An in vitro Study
Authors: Selvaraj Sunantha , Raju Ramesh , Zankari Vidhya , Vijayakumar Manonmani 
Published: September 2015

ABSTRACT
The dental profession has long been concerned with the problem of matching the appearance of porcelain restorations with a patient's natural dentition. The esthetics of any restoration depends on outline form, surface form, translucency and color.

Purpose
The objective of this study is to find out the adequate porcelain thickness required for metal ceramic restorations to match the color of the shade guide and effect of repeated firing on quality and physical characteristics of dental ceramics.

Methods
Preparation of samples done first by preparing alloy substructure. A total of 15 samples of uniform thickness 0.5 mm was prepared using Ni-Cr alloy. Fusion of porcelain to alloy substructure done. Fifteen samples, five 0.5 mm thickness samples, five 1 mm samples and five 1.5 mm porcelain thickness samples were prepared. Color evaluation done by spectrophotometer.

Statistic analysis
Statistic analysis methods employed in the present study were ANOVA-one way, Scheffe's post hoc test and paired samples ‘t’ test.

Conclusion
The thickness of porcelain significantly affects the color of a given porcelain sample. Increasing the thickness gives better results. On repeated firings two and 10 firing did not affect the color stability.

How to cite this article
Raju R, Selvaraj S, Zankari V, Vijayakumar M. A Spectrophotometric Analysis of Color Changes in Metal Ceramic Restorations by Varying Porcelain Thickness and Repeated Firings: An in vitro Study. Int J Prosthodont Restor Dent 2015;5(2):38-43
A Clinical Pathway for Fabrication of Immediate Complete Denture
Authors: Tuncel Ilkin , Celik Gozde 
Published: September 2015

ABSTRACT
Immediate complete dentures have a significant role when patient's all teeth should be extracted. The dentures are fabricated before all the remaining teeth were extracted, and immediately delivered to the patient after the extraction procedure. This article presents a practical fabrication method for complete immediate denture with the use of patient's existing fixed partial denture (FPD). Advantages and disadvantages of this treatment method were emphasized.

How to cite this article
Tuncel I, Celik G. A Clinical Pathway for Fabrication of Immediate Complete Denture. Int J Prosthodont Restor Dent 2015;5(2):60-62
PROMOÇÃO DA QUALIDADE DE VIDA NO TRABALHO: RELATO DE EXPERIÊNCIA DE UM WORKSHOP ENVOLVENDO OS TRABALHADORES DE ENFERMAGEM
Authors: Telles Anna Claúdia Maurício 
Published: September 2015

O objetivo do relato é descrever a experiência da realização de um workshop direcionado à Promoção da Qualidade de Vida no Trabalho com trabalhadores de enfermagem. Trata-se de relato de experiência sobre a realização de um workshop com trabalhadores de enfermagem de um hospital universitário. Participaram do workshop 60 trabalhadores de enfermagem em seis estações de trabalho destinadas à Promoção da Qualidade de Vida no Trabalho. Foram realizadas seis estações de trabalho, simultaneamente, com aproximadamente 10 trabalhadores em cada uma e duração média de 30 minutos. As estações foram conduzidas por enfermeiros e fisioterapeutas com o apoio de docente e temáticas relevantes para a Saúde do trabalhador. O relato visa contribuir para ampliação das discussões sobre o tema, oferecendo subsídios para repensar o processo de trabalho e as possíveis intervenções com vistas à melhoria das condições de trabalho, empoderamento dos trabalhadores no tocante ao autocuidado e prevenção de acidentes e doenças.