bluuebunny/crossref_metadata_2025_split huggingface dataset:
A rapid and sensitive LC‐MS/MS method for the determination of osthole in rat plasma: application to pharmacokinetic study
Authors: Yun Fei , Kang An , Shan Jinjun , Zhao Xiaoli , Bi Xiaolin , Di Liuqing 
Published: January 2013

ABSTRACTOsthole, a major component isolated from the fruit of Cnidium monnieri (L.) Cusson, has been widely used in traditional Chinese medicine. We developed and validated a rapid and sensitive LC‐MS/MS method for the quantification of osthole in rat plasma. Sample preparation involved simple liquid–liquid extraction by ethyl acetate after addition of imperatorin as internal standard (IS). The analyte was separated using a C18 column with the mobile phase of methanol–0.1% formic acid (80:20, v/v) at a flow rate of 0.4 mL/min. The elutes were detected under positive electrospray ionization in multiple reaction monitoring mode. The method was sensitive with 0.5 ng/mL as the lower limit of detection. Good linearity was obtained over the range of 1.0–500.0 ng/mL. The intra and inter‐batch accuracy for osthole in rat plasma samples ranged from 99.5 to 108.1% and the variation was <8.9%. The stability, extraction efficiency and matrix effect were also acceptable. This method was successfully applied to the pharmacokinetic study of osthole in rat after intravenous and oral administration. Copyright © 2013 John Wiley & Sons, Ltd.
A new approach for pharmacokinetic studies of natural products: measurement of isoliquiritigenin levels in mice plasma, urine and feces using modified automated dosing/blood sampling system
Authors: Han Seung Yon , Chin Young‐Won , Choi Young Hee 
Published: January 2013

ABSTRACTThe present study was undertaken to investigate the pharmacokinetics of isoliquiritigenin (isoLQ) as determined by the automated dosing/blood sampling (ABS) and traditional manual blood sampling techniques in awake and freely moving mice using combined liquid chromatography tandem mass spectrometry. Pharmacokinetic comparison was conducted by allocating mice into two groups; an ABS group (intravenous study and oral studies, n = 5 each) and a manual group (intravenous and oral studies; n = 5 each). Significant differences in pharmacokinetic parameters (area under the curve and clearances) were observed between ABS and manual groups. This could be mainly due to the blood sampling site difference (via heart puncture in traditional manual group and via carotid artery in ABS groups). The low F of isoLQ could be mainly due to a considerable gastrointestinal and/or hepatic first‐pass effect and not to incomplete absorption. The driving force for distribution and elimination of drugs is its concentration in the arterial blood. Therefore, the ABS method was found to be a useful drug development tool for accelerating the process of preclinical in vivo studies and for obtaining reliable and accurate pharmacokinetic parameters in mice. Copyright © 2013 John Wiley & Sons, Ltd.
Three‐dimensional demonstration of the lymphatic system in the lower extremities with multi‐detector‐row computed tomography: A study in a cadaver model
Authors: Yamazaki Shun , Suami Hiroo , Imanishi Nobuaki , Aiso Sadakazu , Yamada Minoru , Jinzaki Masahiro , Kuribayashi Sachio , Chang David W. , Kishi Kazuo 
Published: January 2013

AbstractSentinel lymph node biopsy (SLNB) has had a great impact on the staging and treatment of cancer. The purpose of this study was to study the lymphatic anatomy of the lower extremities by constructing three‐dimensional images using multi‐detector‐row computed tomography (MDCT). To select appropriate contrast media for MDCT lymphatic imaging in a cadaver, we tested four kinds of contrast media by injecting them into fresh swine kidneys. After the suitable contrast medium was selected, 10 lower extremities from 5 fresh cadavers were studied. After injection of the contrast medium, each lower extremity was scanned with high‐spatial‐resolution MDCT. The zinc oxide mixture was found to be the most appropriate contrast formula for MDCT imaging of cadaver lymphatics in terms of CT value and no extravasation. The high‐resolution MDCT imaging revealed two different superficial lymphatic pathways in the legs. One lymphatic pathway accompanying the great saphenous vein had a constant course and was connected to the superficial inguinal lymph nodes. However, another pathway, along the small saphenous vein, was variable. Some of the deep lymphatic vessels bypassed the inguinal lymph nodes. Using a new protocol, we were able to construct three‐dimensional images of the lower extremity lymphatics in a cadaver model. MDCT imaging provided novel information about two different superficial lymphatic pathways in the lower extremities. Clin. Anat., 2013. © 2013 Wiley Periodicals, Inc.
Anatomical basis of laparoscopic medial‐to‐lateral mobilization of the descending colon
Authors: Bonnet S. , Abid B. , Wind P. , Delmas V. , Douard R. 
Published: January 2013

AbstractIn laparoscopic colorectal resection, the medial‐to‐lateral approach has been largely adopted. This approach can be initiated by the division of either the inferior mesenteric artery (IMA) or the inferior mesenteric vein (IMV). This cadaveric study aimed to establish the feasibility of IMV dissection as the initial landmark of medial‐to‐lateral left colonic mobilization for evaluating the size of the peritoneal window between the IMV at the lower part of the pancreas and the origin of the IMA (IMA‐IMV distance) and the point of origin of the IMA compared to the lower edge of the third part of the duodenum (IMA‐D3 distance). These distances were recorded on 30 fresh cadavers. The IMA‐D3 distance was 0.4 ± 2.2 cm (mean ± SD). The IMA originated from the aorta at the level of or below the D3 in 21 cases (70%). The IMA‐IMV distance was 5.5 ± 1.8 cm and was greater or equal to 5 cm (large window) in 21 cases (70%). IMA‐IMV distance was correlated with IMA‐D3 showing that a large window was inversely correlated with a low IMA origin (P < 0.001). IMA‐D3 distance was not correlated with weight, height and sex. IMA‐IMV distance was largerin male (6.7 ± 0.9 vs. 4.9 ± 1.8, P = 0.001) and correlated with weight, (r = 0.60, 95%CI = 0.03–0.10, P < 0.001) and height (r = 0.54, 95%CI = 0.05–0.21, P = 0.002). IMV can be used as the initial landmark for laparoscopic medial‐to‐lateral dissection in two‐thirds of cases. A too‐small window can require first IMA division. The choice between the two different medial‐to‐lateral approaches could be made by evaluating the anatomical relationship between IMA, IMV, and D3. Clin. Anat., 2013. © 2013 Wiley Periodicals, Inc.
Nucleoterpenes of Thymidine and 2′‐Deoxyinosine: Synthons for a Biomimetic Lipophilization of Oligonucleotides
Authors: Köstler Karl , Werz Emma , Malecki Edith , Montilla‐Martinez Malayko , Rosemeyer Helmut 
Published: January 2013

Abstract2′‐Deoxyinosine (1) and thymidine (7) were N‐alkylated with geranyl and farnesyl moieties. These hydrophobic derivatives, 3a and 3b, and 9a and 9b, respectively, represent the first synthetic biomimetic nucleoterpenes and were subsequently 5′‐protected and converted into the corresponding 3′‐O‐phosphoramidites, 5a and 5b and 11a and 11b, respectively. The latter were used to prepare a series of lipophilized oligonucleotide dodecamers, a part of which were additionally labelled with indocarbocyanine fluorescent dyes (Cy3 or Cy5), 18–23. The insertion of the lipooligonucleotides into, as well as duplex formation at artificial lipid bilayers was studied by single‐molecule fluorescence spectroscopy and fluorescence microscopy.
Synthesis and Evaluation of Gambogic Acid Derivatives as Antitumor Agents. Part III
Authors: Guo Xiao‐Ke , Sun Hao‐Peng , Shen Shen , Sun Yuan , Xie Fan‐Lei , Tao Lei , Guo Qing‐Long , Jiang Cheng , You Qi‐Dong 
Published: January 2013

AbstractGambogic acid (GA) has been reported as a potent apoptosis inducer. Previously, we have reported chemical modification at C(34) and C(39) of GA, leading to some agents with improved activity. To investigate the further structureactivity relationship (SAR) and preliminary mechanism of GA activity, a series of derivatives with modified prenyl side chains of GA were synthesized and evaluated. Most of the derivatives showed potent inhibitory activities against the proliferation of HepG2 and A549 cell lines. Compound 4 was selected for further mechanistic studies due to its outstanding activity. It was established that 4 induces the apoptosis of HepG2 cells by using Annexin‐V/PI double staining and Western blot assay, thus, compound 4 can serve as a promising lead compound for the development of novel apoptosis in anticancer treatment.
Variation in the Fatty‐Acid Content in Seeds of Various Black, Red, and White Currant Varieties
Authors: Šavikin Katarina P. , Ðorđević Boban S. , Ristić Mihailo S. , Krivokuća‐Ðokić Dragana , Pljevljakušić Dejan S. , Vulić Todor 
Published: January 2013

AbstractCurrant seeds, a by‐product of juice production, are recognized as a valuable source of oil rich in polyunsaturated fatty acids. We have evaluated 28 currant varieties for their oil content and fatty‐acid composition. The oil content in the seeds ranged from 18.2–27.7%, and no statistical difference between varieties of different fruit color were recorded. Furthermore, the estimated oil yields in the field production ranged from 26.4–212.4 kg/ha. The GC and GC/MS chemical profiles of the seed oils extracted from all examined varieties were common for currants. Linoleic acid (LA) was the major component, with contents ranging from 32.7–46.9% of total fatty acids, followed by α‐linolenic acid (ALA; 2.9–32.0 %), oleic acid (OA; 9.8–19.9%), γ‐linolenic acid (GLA; 3.3–18.5%), palmitic acid (PA; 4.4–8.1%), stearidonic acid (SDA; 2.2–4.7%), and stearic acid (SA; 1.2–2.4%). Quantitative differences in the fatty‐acid profiles between varieties of different fruit color were observed. Blackcurrant varieties showed significantly higher contents of LA, GLA, and PA than red and white currant varieties, whereas significantly higher amounts of ALA and OL were detected in the red and white varieties. Cluster analysis based on the chemical oil profiles joined the blackcurrants in one group, while most of the red and white cultivars joined in a second group at the same linkage distance.
On the Pathways for CO Egress from Carboxy Human Cytoglobin. A Molecular‐Dynamics Investigation
Authors: Pietra Francesco 
Published: January 2013

AbstractThis work discloses two bona fide gates through which the CO ligand can leave the distal cavity of carboxy human cytoglobin, reaching the solvent. The investigation was based on molecular dynamics, aided by a minimal randomly‐oriented force applied to the ligand. The shortest pathway progresses toward the main gate, H81‐R84, in the open state, with the H81 imidazole moiety turned toward the solvent. A longer pathway develops toward the diametrically opposed W31‐W151 gate. In between, CO may be entrapped into binding cavities, either along the path toward the gates, or in a cul‐de‐sac, from which CO may even be incapable to escape. This behavior contrasts with carboxy myoglobin, where the corresponding H64 gate, when opened, is the sole used by CO to get to the solvent. These observations, which could hold also for other small ligands of biological interest, such as O2, NO, and NO$\rm{{_{3}^{-}}}$, provide an answer to a neglected aspect of the mysterious six‐coordinated globins.
Permeation through Phospholipid Bilayers, Skin‐Cell Penetration, Plasma Stability, and CD Spectra of α‐ and β‐Oligoproline Derivatives
Authors: Kolesinska Beata , Podwysocka Dominika J. , Rueping Magnus A. , Seebach Dieter , Kamena Faustin , Walde Peter , Sauer Markus , Windschiegl Barbara , Meyer‐Ács Mira , Vor der Brüggen Marc , Giehring Sebastian 
Published: January 2013

AbstractAfter a survey of the special role, which the amino acid proline plays in the chemistry of life, the cell‐penetrating properties of polycationic proline‐containing peptides are discussed, and the widely unknown discovery by the Giralt group (J. Am. Chem. Soc. 2002, 124, 8876) is acknowledged, according to which fluorescein‐labeled tetradecaproline is slowly taken up by rat kidney cells (NRK‐49F). Here, we describe details of our previously mentioned (Chem. Biodiversity 2004, 1, 1111) observation that a hexa‐β3‐Pro derivative penetrates fibroblast cells, and we present the results of an extensive investigation of oligo‐L‐ and oligo‐D‐α‐prolines, as well as of oligo‐β2h‐ and oligo‐β3h‐prolines without and with fluorescence labels (1–8; Fig. 1). Permeation through protein‐free phospholipid bilayers is detected with the nanoFAST biochip technology (Figs. 2–4). This methodology is applied for the first time for quantitative determination of translocation rates of cell‐penetrating peptides (CPPs) across lipid bilayers. Cell penetration is observed with mouse (3T3) and human foreskin fibroblasts (HFF; Figs. 5 and 6–8, resp.). The stabilities of oligoprolines in heparin‐stabilized human plasma increase with decreasing chain lengths (Figs. 9–11). Time‐ and solvent‐dependent CD spectra of most of the oligoprolines (Figs. 13 and 14) show changes that may be interpreted as arising from aggregation, and broadening of the NMR signals with time confirms this assumption.
Beetles Do It Differently: Two Stereodivergent Cyclisation Modes in Iridoid‐Producing Leaf‐Beetle Larvae
Authors: Kunert Maritta , Rahfeld Peter , Shaker Kamel H. , Schneider Bernd , David Anja , Dettner Konrad , Pasteels Jacques M. , Boland Wilhelm 
Published: January 2013

AbstractLarvae of the Chrysomelina species Phaedon cochleariae, Hydrothassa marginella, Phratora vulgatissima, Gastrophysa viridula, Gastrophysa atrocyanea, Gastrophysa cyanea and Gastrophysa polygoni produce the iridoid chrysomelidial (1) to defend themselves against predators. Feeding experiments with a deuterated precursor ([2H5]8‐hydroxygeraniol 9) and in vitro isotope exchange experiments with defensive secretion in 2H2O revealed differences in the cyclisation of the ultimate precursor 8‐oxogeranial (8) to 1, between members of the genus Gastrophysa and all other species. In P. cochleariae, H. marginella and P. vulgatissima 1 is most likely produced by a Rauhut–Currier‐type cyclisation via a “transoid dienamine”, with loss of a single deuterium atom from C(4) of the precursor. In contrast, members of the genus Gastrophysa cyclise 8 via a “cisoid dienamine” intermediate, with exchange of all three deuterium atoms from the methyl group at C(3). To study whether the different cyclisation modes influence the stereochemistry of 1, the absolute configuration of 1 of the larvae was determined by GC‐MS on a chiral column. In accordance with literature (J. Meinwald, T. H. Jones, J. Am. Chem. Soc. 1978, 100, 1883 and N. Shimizu, R. Yakumaru, T. Sakata, S. Shimano, Y. Kuwahara, J. Chem. Ecol. 2012, 38, 29), we found (5S,8S)‐chrysomelidial (1) in H. marginella and P. vulgatissima, but P. cochleariae and all investigated members of the genus Gastrophysa synthesise (5R,8R)‐chrysomelidial (1).
Artificial Multi‐Enzyme Networks for the Asymmetric Amination of sec‐Alcohols
Authors: Tauber Katharina , Fuchs Michael , Sattler Johann H. , Pitzer Julia , Pressnitz Desiree , Koszelewski Dominik , Faber Kurt , Pfeffer Jan , Haas Thomas , Kroutil Wolfgang 
Published: January 2013

AbstractVarious artificial network designs that involve biocatalysts were tested for the asymmetric amination of sec‐alcohols to the corresponding α‐chiral primary amines. The artificial systems tested involved three to five redox enzymes and were exemplary of a range of different sec‐alcohol substrates. Alcohols were oxidised to the corresponding ketone by an alcohol dehydrogenase. The ketones were subsequently aminated by employing a ω‐transaminase. Of special interest were redox‐neutral designs in which the hydride abstracted in the oxidation step was reused in the amination step of the cascade. Under optimised conditions up to 91 % conversion of an alcohol to the amine was achieved.
Stereoselective Multiple Bond‐Forming Transformations (MBFTs): The Power of 1,2‐ and 1,3‐Dicarbonyl Compounds
Authors: Bonne Damien , Constantieux Thierry , Coquerel Yoann , Rodriguez Jean 
Published: January 2013

AbstractAlthough long known, 1,2‐ and 1,3‐dicarbonyl compounds have recently come more and more to prevalence as ideal substrates for the invention of new stereoselective multiple bond‐forming transformations (MBFTs). Herein, a critical appraisal is presented of some of the most spectacular of these MBFTs, which allow the formation from three up to six bonds in highly step‐ and atom‐economical processes.
ChemInform Abstract: From an Icosahedron to a Plane: Flattening Dodecaiodo‐dodecaborate by Successive Stripping of Iodine.
Authors: Farras Pau , Vankova Nina , Zeonjuk Lei Liu , Warneke Jonas , Duelcks Thomas , Heine Thomas , Vinas Clara , Teixidor Francesc , Gabel Detlef 
Published: January 2013

AbstractElectrospray ionization‐ion‐trap mass spectrometry shows that B2I122‐ converts to an intact B12 cluster by successive stripping of single iodine radicals or ions.
ChemInform Abstract: LiCa3Si2N5 — A Lithium Nitridosilicate with a [Si2N5]7‐ Double‐Chain.
Authors: Lupart Saskia , Schnick Wolfgang 
Published: January 2013

AbstractThe title compound is prepared by reaction of Ca with Si(NH)2 and Li3N using Li as a flux (sealed Ta ampule, 900 °C, 12 h).
ChemInform Abstract: Ca5Ni17Ge8 — A Complex Intermetallic Compound Combining Various Structure Motifs of Alkaline‐Earth Nickel Germanides.
Authors: Hlukhyy Viktor , Siggelkow Lisa , Faessler Thomas F. 
Published: January 2013

AbstractThe title compound is prepared by arc melting of the elements followed by annealing (silica tube, Ar, 1050 °C, 24 h).
ChemInform Abstract: Na3SbSe3: Synthesis, Crystal Structure Determination, Raman Spectroscopy, and Ionic Conductivity.
Authors: Pompe Constantin , Pfitzner Arno 
Published: January 2013

AbstractYellow single crystals of the title compound are prepared by solid state reaction of a stoichiometric mixture of anhydrous Na2Se, Sb, and Se in a 3:2:3 ratio (evacuated silica ampule, 723 K, 10 weeks).
ChemInform Abstract: Sr8MgGd(PO4)7:Eu2+: Yellow‐Emitting Phosphor for Application in Near‐Ultraviolet‐Emitting Diode Based White‐Light LEDs.
Authors: Huang Chien‐Hao , Wang De‐Yin , Chiu Yi‐Chen , Yeh Yao‐Tsung , Chen Teng‐Ming 
Published: January 2013

AbstractThe title phosphor is synthesized by solid state reaction of SrCO3, MgO, Gd2O3, (NH4)2HPO4, and Eu2O3 (1200 °C, 8 h) and characterized by powder XRD and photoluminescence spectroscopy.
ChemInform Abstract: Bromine Monofluoride.
Authors: Drews Thomas , Seppelt Konrad 
Published: January 2013

AbstractBrF is prepared from Br2 and F2 in various solvents (EtCN, MeCN/CH2Cl2, CH3Cl, CH2Cl2, C2H5F, CH3F) below ‐100 °C and characterized in solution by 19F NMR and Raman spectroscopy.
ChemInform Abstract: Li5OCl3 and Li3OCl: Two Remarkably Different Lithium Oxide Chlorides.
Authors: Reckeweg Olaf , Blaschkowski Bjoern , Schleid Thomas 
Published: January 2013

AbstractYellow to red, transparent single crystals of Li5OCl3 are prepared by solid state reaction of Li3N, oxygen‐contaminated Li, and YbCl3 in the presence of carbon (Nb container, 1300 K, 3 d).
ChemInform Abstract: New Quaternary Alkali‐Metal Hypodiphosphate Hydrates: Preparation, Crystal Structure, Vibrational Spectrum, and Thermal Behavior of K4P2O6·8H2O and Na2K2P2O6·8H2O in Comparison to Na4P2O6·10H2O.
Authors: Gjikaj Mimoza , Wu Peng , Brockner Wolfgang 
Published: January 2013

AbstractSingle crystals of K4P2O6·8H2O and Na2K2P2O6·8H2O are prepared by addition of KOH to an aqueous solution of hypodiphosphoric acid (20 °C) resp.
ChemInform Abstract: Exploring the Borders of the Zintl‐Klemm Concept: On the Isopunctual Phases Eu5+xMg18‐xGe13 (x = 0.1) and Eu8Mg16Ge12.
Authors: Slabon Adam , Cuervo‐Reyes Eduardo , Kubata Christof , Mensing Christian , Nesper Reinhard 
Published: January 2013

AbstractEu5.1Mg17.9Ge13 (I) and Eu8Mg16Ge12 (II) are prepared by solid state reaction of the elements (Nb ampules, 890—1020 °C, 48 h—16 d).
ChemInform Abstract: The Dimeric [V2O4F6]4‐ Vanadium Oxide‐Fluoride Anion in Na2(M(H2O)2) (V2O4F6) (M: Co2+, Ni2+, and Cu2+).
Authors: Donakowski Martin D. , Vinokur Anastasiya I. , Poeppelmeier Kenneth R. 
Published: January 2013

AbstractThe new compounds (IV) and (VI) crystallize isostructurally in the monoclinic space group P21/c with Z = 2 (single crystal XRD).
ChemInform Abstract: Crystal Structure, Magnetic and Transport Properties of CeRu1‐xNixAl (x = 0.5).
Authors: Janka Oliver , Baumbach Ryan , Ronning Filip , Thompson Joe D. , Bauer Eric D. , Kauzlarich Susan M. 
Published: January 2013

AbstractSingle crystals of CeRu0.5Ni0.5Al are prepared from the elements in a molten Ce0.78Ni0.22 flux (1000 °C for 12 h and 850 °C for 48 h).
ChemInform Abstract: Method for the Efficient Synthesis of Highly‐Substituted Oxetan‐ and Azetidin‐, Dihydrofuran‐ and Pyrrolidin‐3‐ones and Its Application to the Synthesis of (.+‐.)‐Pseudodeflectusin.
Authors: Maegawa Tomohiro , Otake Kazuki , Hirosawa Keichi , Goto Akihiro , Fujioka Hiromichi 
Published: January 2013

AbstractThe title products are prepared by a one‐pot base‐induced cyclization/Horner—Wadsworth—Emmons olefination reaction of starting O,P‐ or N,P‐acetals.
ChemInform Abstract: An Efficient Synthesis of Bridged Heterocycles from an Ir(I) Bis‐Amination/Ring‐Closing Metathesis Sequence.
Authors: Brawn Ryan A. , Guimaraes Cristiano R. W. , McClure Kim F. , Liras Spiros 
Published: January 2013

AbstractA careful screening of amines, solvents and conditions leads to the predominant formation of cis‐divinyl heterocycles (III) which undergo the ring closing metathesis reaction to give the corresponding bicyclo[3.2.1]oct‐6‐enes (IV).
ChemInform Abstract: Intramolecular Cyclization Manifolds of 4‐Alkylpyridines Bearing Ambiphilic Side Chains: Construction of Spirodihydropyridines or Benzylic Cyclization via Anhydrobase Intermediates.
Authors: Parameswarappa Sharavathi G. , Pigge F. Christopher 
Published: January 2013

AbstractPyridines containing a β‐keto amide moiety can be converted into spirocyclic dihydropyridines or lactams depending on the substitution pattern and the conditions.
ChemInform Abstract: Thiosemicarbazone Copper Complexes as Competent Catalysts for Olefin Cyclopropanations.
Authors: Youssef Nabil S. , El‐Seidy Ahmed M. A. , Schiavoni Marco , Castano Brunilde , Ragaini Fabio , Gallo Emma , Caselli Alessandro 
Published: January 2013

AbstractSeveral copper complexes of thiosemicarbazones are prepared and tested as catalysts in the cyclopropanation reaction of α‐methylstyrene (Ia).
ChemInform Abstract: Selective Oxidation of 8,8′‐Hydroxylated Binaphthols to Bis‐spironaphthalenones or Binaphtho‐para‐ and Binaphtho‐ortho‐quinones.
Authors: Podlesny Erin E. , Carroll Patrick J. , Kozlowski Marisa C. 
Published: January 2013

AbstractIn the presence of different oxidants (O2/Co(II)‐catalyst, IBX, PhI(OAc)2), the title binaphthols are converted to the quinone derivatives.
ChemInform Abstract: Oxidation of α‐Trifluoromethyl Alcohols Using a Recyclable Oxoammonium Salt.
Authors: Kelly Christopher B. , Mercadante Michael A. , Hamlin Trevor A. , Fletcher Madison H. , Leadbeater Nicholas E. 
Published: January 2013

AbstractA simple, mild, and efficient method for the conversion of α‐trifluoromethyl alcohols into trifluoromethyl ketones is reported.
ChemInform Abstract: Enantioselective Borohydride Reduction of Aliphatic Ketones Catalyzed by Ketoiminatocobalt(III) Complex with 1‐Chlorovinyl Axial Ligand.
Authors: Tsubo Tatsuyuki , Chen Hsiu‐Hui , Yokomori Minako , Fukui Satoshi , Yamada Tohru 
Published: January 2013

AbstractNewly designed chiral cobalt(III) complexes, e.g. (I), are applied to the enantioselective borohydride reduction of aliphatic ketones using 1,1,1‐trichloroethane to generate the corresponding 1‐chlorovinyl cobalt(III) derivatives as reactive intermediate.