bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clinical Impacts of Allograft Biopsy in Renal Transplant Recipients 10 Years or Longer After Transplantation
Authors: Namba-Hamano Tomoko , Hamano Takayuki , Doi Yohei , Hiraoka Atsuko , Yonishi Hiroaki , Sakai Shinsuke , Takahashi Atsushi , Mizui Masayuki , Nakazawa Shigeaki , Yamanaka Kazuaki , Kakuta Yoichi , Imamura Ryoichi , Nonomura Norio , Isaka Yoshitaka 
Published: July 2024

We aimed to investigate the clinical value of allograft biopsy performed long after renal transplantation. We retrospectively evaluated 99 allograft biopsies in recipients with transplantation vintages of 10 years or longer. Mixed-effects model showed that 1-year estimated glomerular filtration rate (eGFR) slopes after biopsy were significantly greater than those before biopsy [−3.13, −4.42 mL/min/1.73 m2/year, p = 0.01]. Renal biopsy changed the treatment strategies in more than half of the patients. Improvement in eGFR slopes was pronounced in 51 patients with treatment modification based on the biopsy results [2.27 (95% confidence interval (CI): 0.66, 3.89) mL/min/1.73 m2/year], whereas no improvement was observed in those without [0.33 (95% CI: −1.05, 1.71) mL/min/1.73 m2/year, Pinteraction = 0.001]. Among the treatment modifications, enhancement of immunosuppression (IS) led to the most remarkable improvement in eGFR slope. Patients with g scores ≥2 were more likely to receive IS enhancement than those with g scores = 0 [odds ratio; 15.0 (95% CI: 1.65, 136)]. Patients with active glomerulitis (g ≥ 1) without chronicity (cg ≤ 1) showed the most significant improvement in eGFR slope. Given the prevalence of active glomerulitis (g ≥ 1, 21%), which is responsive to treatment even long after transplantation, and the observed magnitude of eGFR slope improvement, renal biopsy can indeed improve allograft prognosis.
Identification of GTF2I Polymorphisms as Potential Biomarkers for CKD in the Han Chinese Population
Authors: Lu Kevin , Chiu Kun-Yuan , Chen I-Chieh , Lin Guan-Cheng 
Published: July 2024

Key Points

Genetic factors are key players in CKD, with two linked single-nucleotide polymorphisms in the GTF2I gene, associated with CKD susceptibility in the Taiwanese population.Individuals with specific GTF2I genotypes (CT/TT for rs117026326 and CT/CC for rs73366469) show higher CKD prevalence and earlier onset.Men with the specific genotypes of rs117026326 and rs73366469 face a heightened CKD risk compared with women, particularly at lower eGFR.

Background
CKD poses a global health challenge, but its molecular mechanisms are poorly understood. Genetic factors play a critical role, and phenome-wide association studies and genome-wide association studies shed light on CKD's genetic architecture, shared variants, and biological pathways.

Methods
Using data from the multicenter collaborative precision medicine cohort, we conducted a retrospective prospectively maintained cross-sectional study. Participants with comprehensive information and genotyping data were selected, and genome-wide association study and phenome-wide association study analyses were performed using the curated Taiwan Biobank version 2 array to identify CKD-associated genetic variants and explore their phenotypic associations.

Results
Among 58,091 volunteers, 8420 participants were enrolled. Individuals with CKD exhibited higher prevalence of metabolic, cardiovascular, autoimmune, and nephritic disorders. Genetic analysis unveiled two closely linked single-nucleotide polymorphisms, rs117026326 and rs73366469, both associated with GTF2I and CKD (r
2 = 0.64). Further examination revealed significant associations between these single-nucleotide polymorphisms and various kidney-related diseases. The CKD group showed a higher proportion of individuals with specific genotypes (CT/TT for rs117026326 and CT/CC for rs73366469), suggesting potential associations with CKD susceptibility (P < 0.001). Furthermore, individuals with these genotypes developed CKD at an earlier age. Multiple logistic regression confirmed the independent association of these genetic variants with CKD. Subgroup analysis based on eGFR demonstrated an increased risk of CKD among carriers of the rs117026326 CT/TT genotypes (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.07 to 1.24; P < 0.001; OR, 1.32, 95% CI, 1.04 to 1.66; P = 0.02, respectively) and carriers of the rs73366469 CT/CC genotypes (OR, 1.13; 95% CI, 1.05 to 1.21; P < 0.001; OR, 1.31; 95% CI, 1.08 to 1.58; P = 0.0049, respectively). In addition, men had a higher CKD risk than women at lower eGFR levels (OR, 1.35; 95% CI, 1.13 to 1.61; P < 0.001).

Conclusions
Our study reveals important links between genetic variants GTF2I and susceptibility to CKD, advancing our understanding of CKD development in the Taiwanese population and suggesting potential for personalized prevention and management strategies. More research is needed to validate and explore these variants in diverse populations.
Pentingnya Merumuskan Visi dan Misi Pada Lembaga Pendidikan
Authors: Aulia Yenni , Ose Fitria , Idris Idris , Rusdinal Rusdinal , Anisah Anisah 
Published: July 2024

This research aims to summarize and describe the importance of formulating a vision and mission in educational institutions. The method used in writing this scientific article is by using the library research method. In an educational institution, the vision and mission are very important. The vision and mission of an educational institution is the foundation that serves as a guide for all stakeholders, from managers, teaching staff, to students. The vision reflects the image of the future desired by the institution, while the mission describes the concrete steps that will be taken to realize that vision. Therefore, the success of an organization is largely determined by the process of formulating the vision and mission of the educational institution. Formulating a vision and mission also plays a key role in increasing the accountability of educational institutions. By setting specific goals in the mission, institutions have a basis for measuring their performance and achievements. This helps create high standards of quality and accountability, which in turn contributes to improving the overall quality of education. Schools must carry out their duties well as educational institutions whose mission is to achieve educational goals. In recognizing its role as an educational institution, schools must be managed well to achieve the formulated educational goals optimally without hesitation
Модель ринку цифрових криптовалют у рамках диференціальної гри якості
Authors: Малюков Володимир Павлович , Малюкова Інна Володимирівна 
Published: July 2024

Стаття присвячена розробці неперервної багатофакторної моделі ринку цифрових криптовалют (ЦКВ) у рамках схеми диференціальної гри якості. Розглянуто ігрову модель торговельної сесії на ринку ЦКВ. Показано, що керованість процесу на торговельній сесії може бути описана з погляду ігрового підходу на основі рішення системи білінійних диференціальних ігор, які дають змогу адекватно описати процес розподілу обсягів цифрових криптовалют. Такий підхід не відкидає реалізацій гри з боку загального колективного контрагента. Він дозволяє розглянути випадки, що призводять до нестабільності співвідношення фінансових ресурсів гравців, наприклад, ЦКВ1 до ЦКВ2 і навпаки. Новизна моделі полягає у тому, що вона відрізняється від існуючих підходів рішенням білінійної диференціальної гри якості з кількома термінальними поверхнями. Знайдено рішення нової білінійної диференціальної гри якості з залежними рухами, що адекватно описує процедуру купівлі-продажу ЦКВ на ринку криптовалют. Проілюстровано результати обчислювального експерименту, під час якого враховувалися різні співвідношення параметрів, що описують процес купівлі-продажу ЦКВ. Отримані результати можуть виявитися корисними для запобігання ситуаціям курсової нестабільності на ринку інвестицій у ЦКВ. Також їх можна використовувати як деякі рекомендації щодо вибору керуючих впливів для підтримки курсової стабільності на ринку інвестування у ЦКВ на рівні великих банківських гравців. Запропонований підхід дав можливість конструктивного знаходження стратегій валютної стабільності на ринку ЦКВ. Він полягає в адекватності розробленої моделі неперервному процесу купівлі-продажу ЦКВ, що дозволило використовувати інструментарій білінійних диференціальних ігор якості для знаходження стратегій гравців. Наведено розрахунки, в яких розглянуто різні співвідношення параметрів, що характеризують процеси на ринку ЦКВ. Отримані результати дозволяють учасникам цього ринку мати інструменти, які підтримуватимуть валютну стабільність на ринках традиційних валют і ЦКВ. Запропонована модель може бути використана у програмних продуктах, що застосовуються на торгових майданчиках, призначених для проведення угод по ЦКВ.
Artificial intelligence in management problems
Authors: Voronin Albert , Savchenko Alina 
Published: July 2024

The problems of optimization of a controlled object pursuing several goals are considered. A model of multi-criteria optimization has been obtained, which allows the controlled object to realize all the goals set in the entire range of possible situations without the direct participation of a person. A systematic approach to the problem of vector optimization made it possible to combine models of individual trade-off schemes into a single integral structure that adapts to the situation of making a multi-criteria decision. The advantage of the concept of a non-linear trade-off scheme is the possibility of making a multi-criteria decision formally, which is a hallmark of artificial intelligence. The apparatus of the nonlinear trade-off scheme, developed as a formalized tool for studying management systems with conflicting criteria, allows the artificial intelligence system to solve practically multi-criteria problems of a wide class. Artificial intelligence systems are created in order to replace a person as a decision maker in this or that situation. AI systems such as robots, decision support systems, neural networks, etc. operate in conditions that a person considers unfavorable for himself. Thus, a demining robot operates in an environment that is dangerous for a sapper. Decision support systems are usually used in conditions of time pressure or in aggressive environments. Neural network classifiers process volumes of information that exceed the capabilities of a human operator, etc. Replacing a person with an AI system requires the formalization of both the formulation and the process of solving the problem. Subjective factors should be excluded from the solution algorithm. A special place among such systems is occupied by those which functioning is evaluated by a set of conflicting quality criteria. When solving a specific problem of vector optimization, the decision maker creates his own model of the objective function (utility function) in accordance with his preferences.
HIGHLY RELIABLE "ETERNAL" STORAGE OF INFORMATION: IDEOLOGICAL FORMULATIONS
Authors: СТРОЕВ С.А. 
Published: July 2024

В статье рассматриваются различные варианты «идеологического» оформления проекта долгосрочного высоконадёжного хранения данных. Версия «Послания человечества Вселенной» отвечает романтическому и оптимистическому взгляду на будущее человечества как единого целого в духе научной фантастики и веры в дальнейшие перспективы научно-технического прогресса и миссии освоения и колонизации человечеством Космоса. Версия «азимовского Основания» или «Хранилища Судного дня» отвечает представлениям о глубоком кризисе современной цивилизации, зашедшей в тупик своего развития, о вероятном в обозримом будущем глубоком цивилизационном регрессе и наступлении своего рода новых «Тёмных веков». Версия суверенных национальных проектов соответствует представлению о конце эпохи глобализации и о возвращении к многополярному миру, разделённому на конкурирующие друг с другом цивилизации, организованные в виде неоимперских геополитических субъектов. При этом за разными идеологическими оформлениями, обращёнными к носителям разных мировоззрений, картин мира, ценностных установок и образов будущего, с точки зрения конкретных практических действий, технических и организационных решений фактически стоит один и тот же требующий реализации проект. Статья является частью серии публикаций, посвящённых проекту «Ковчег», и прямым продолжением статьи «Высоконадёжное «вечное» хранение информации: концепция и практические реализации», публикуется впервые.
The article discusses various options for the "ideological" design of a long-term highly reliable data storage project. The version of the "Message of Humanity to the Universe" corresponds to a romantic and optimistic view of the future of humanity as a whole in the spirit of science fiction and faith in the future prospects of scientific and technological progress and the mission of space exploration and colonization by mankind. The version of the "Asimov Foundation" or "Doomsday Vault" corresponds to the ideas of a deep crisis of modern civilization, which has reached a dead end in its development, of a deep civilizational regression likely in the foreseeable future and the onset of a kind of new "Dark Ages". The version of sovereign national projects corresponds to the idea of the end of the era of globalization and the return to a multipolar world divided into competing civilizations organized in the form of neo-imperial geopolitical entities. At the same time, behind the different ideological designs addressed to the bearers of different worldviews, worldviews, values and images of the future, from the point of view of concrete practical actions, technical and organizational solutions, there is actually the same project requiring implementation. The article is part of a series of publications dedicated to the Ark project and a direct continuation of the article "Highly Reliable"eternal" information Storage: concept and Practical implementations", published for the first time.
SMALL FORMS OF MANAGEMENT IN THE AGRICULTURAL SECTOR OF THE REGION: CURRENT STATE, PROBLEMS AND PROSPECTS OF DEVELOPMENT
Authors: ЗАЙЦЕВА Е.В. , ЖУПЛЕЙ И.В. 
Published: July 2024

В статье рассмотрено современное состояние и выявлены общие тенденции развития малых форм хозяйствования (МФХ) в аграрном секторе Костромской области, а так же определена их роль в развитии сельского хозяйства региона в условиях реализации финансовых мер государственной поддержки, определены факторы, сдерживающие развитие указанного аграрного сегмента и представлены перспективные направления его развития. Новизна исследования заключается в выявлении взаимосвязи развития малых форм хозяйствования в сельском хозяйстве и грантовой поддержки фермеров в рамках программ акселерации. Результаты исследования отражают наличие общих тенденций развития малых форм хозяйствования в аграрном секторе на региональном уровне, связанных с особенностями финансовой поддержки по программам акселерации. Полученные результаты могут использоваться при формировании системы мер государственной поддержки малых форм хозяйствования в аграрном секторе Костромской области.
The article examines the current state and identifies general trends in the development of small business entities (MFCs) in the agricultural sector of the Kostroma region, as well as defines their role in the development of agriculture in the region in the context of the implementation of financial measures of state support, identifies factors constraining the development of this agricultural segment and presents promising directions for its development. The novelty of the study is to identify the relationship between the development of small forms of farming in agriculture and grant support to farmers within the framework of acceleration programs. The results of the study reflect the presence of general trends in the development of small businesses in the agricultural sector at the regional level, related to the specifics of financial support for acceleration programs. The results obtained can be used in the formation of a system of state support measures for small businesses in the agricultural sector of the Kostroma region.
COMPARATIVE INDICATORS OF FAMILY BUSINESS AND OTHER FORMS OF ENTREPRENEURSHIP
Authors: МАХНЕНКО С.И . , ВАСЮК А.И. 
Published: July 2024

В данной статье рассматривается семейный бизнес как одна из форм предпринимательской деятельности, производится сравнение с иными формами бизнеса. Рассматриваются цели и мотивы семейных предприятий, сходства и различия между семейным и несемейным бизнесом, а также выводится гипотеза относительно подхода семейного бизнеса к цели максимизации прибыли. Анализируется мотивация семейных предприятий, их ключевые особенности, а также тенденция данных предприятий к интернационализации.
This article examines family business as one of the forms of entrepreneurial activity, and compares it with other forms of business. The goals and motives of family enterprises, similarities and differences between family and non-family businesses are considered, and a hypothesis is derived regarding the approach of family business to the goal of maximizing profits. The motivation of family enterprises, their key features, as well as the tendency of these enterprises to internationalization are analyzed.
Investigating the mechanism of SiO2/4H-SiC interface traps passivation by boron incorporation through FT-IR analysis of near-interface SiO2
Authors: Wang Runze , Noguchi Munetaka , Hino Shiro , Kita Koji 
Published: July 2024

Abstract
This study investigates the effect of boron-incorporation (B-incorp) on SiO2 properties near the SiO2/4H-SiC interface by Fourier transforms infrared spectroscopy with attenuated total reflection mode. We focus on the range of Si–O–Si asymmetric stretching vibrations, whereas B-incorp samples exhibited a different peak shift trend compared to the thermal oxidized samples. The observed peak shift, corroborated by the calculated spectral simulation, suggests a reduction in oxygen deficiency near the interface for B-incorp samples. This suggests a potential link between B-incorp and the passivation of traps near the interface, possibly through its influence on SiO2 stoichiometry.
Study of models and mechanical properties of Miura-Ori structures
Authors: Ченцов А.В. , Сокоренко А.В. 
Published: July 2024

Механические метаматериалы - искусственные материалы, у которых механические свойства преимущественно зависят от их структуры, а не от характеристик материала из которого они изготовлены. Из множества разработанных структур метаматериалов можно выделить класс структур, разработанных на основе искусства оригами – складывания бумаги, позволяющего из плоского листа бумаги получать трёхмерные структуры различной сложности. В работе представлены общие сведения о механических метаматериалах, со структурой, основанной на методе складывания Миура-ори, рассмотрены области их применения, преимущества, и приведён краткий обзор исследований таких метаматериалов.
Mechanical metamaterials are artificial materials whose mechanical properties primarily depend on their structure rather than on the characteristics of the material from which they are made of. From the many developed metamaterial structures, a class of structures developed based on the art of origami can be distinguished. Origami is the art of paper folding, which allows you to create three-dimensional structures of varying complexity made of a flat sheet of paper. The paper presents general information on mechanical metamaterials, with a structure based on the Miura-ori folding method, discusses their areas of application, advantages, and provides a brief overview of research on such metamaterials.
Sulfur Dioxide and Other Molecular Species in the Atmosphere of the Sub-Neptune GJ 3470 b
Authors: Beatty Thomas G. , Welbanks Luis , Schlawin Everett , Bell Taylor J. , Line Michael R. , Murphy Matthew , Edelman Isaac , Greene Thomas P. , Fortney Jonathan J. , Henry Gregory W. , Mukherjee Sagnick , Ohno Kazumasa , Parmentier Vivien , Rauscher Emily , Wiser Lindsey S. , Arnold Kenneth E. 
Published: July 2024

Abstract
We report observations of the atmospheric transmission spectrum of the sub-Neptune exoplanet GJ 3470 b taken using the Near-Infrared Camera on JWST. Combined with two archival Hubble Space Telescope/Wide-Field Camera 3 transit observations and 15 archival Spitzer transit observations, we detect water, methane, sulfur dioxide, and carbon dioxide in the atmosphere of GJ 3470 b, each with a significance of >3σ. GJ 3470 b is the lowest-mass—and coldest—exoplanet known to show a substantial sulfur dioxide feature in its spectrum, at M

p
= 11.2 M
⊕ and T
eq = 600 K. This indicates that disequilibrium photochemistry drives sulfur dioxide production in exoplanet atmospheres over a wider range of masses and temperatures than has been reported or expected. The water, carbon dioxide, and sulfur dioxide abundances we measure indicate an atmospheric metallicity of approximately 100× solar. We see further evidence for disequilibrium chemistry in our inferred methane abundance, which is significantly lower than expected from equilibrium models consistent with our measured water and carbon dioxide abundances.
Contribution de l’investissement à impact pour le développement humain de l’économie ? Approche énantiologique
Authors: Bonnet Daniel 
Published: July 2024

Cet article propose une analyse critique de la notion « d’investissement à impact », envers la transformation des comportements : comment cette transformation peut favoriser ce type d’investissement en entreprise, quels sont les enjeux, défis et limites ? L’investissement à impact qualifie les investissements contribuant au développement de stratégies innovantes, d’essence socio-économique. Ils incorporent des exigences sociales, environnementales et sociétales. Il est stipulé par son intentionnalité, l’additionnalité des attributs, et sa mesurabilité. Notamment, il doit convertir des externalités négatives et produire des externalités positives. Il doit également générer une performance financière additionnelle, car il est aussi une épargne qui finance un investissement vertueux. La recherche est réalisée dans le cadre de la théorie socio-économique des organisations. Elle mobilise des incorporats d’investigation. Sont notamment mobilisés les incorporats définissant une approche énantiologique, à savoir une approche examinant les transformations envers leur impact sur la transformation des comportements. Codes JEL : O31, D21, D24, G4
Does the deployment of the ISO 9001 standard have an effect on intellectual capital?
Authors: Mokhlis Chams-Eddoha , Diop Yamadou , Boualou Widad 
Published: July 2024

Purpose: The objective of this paper is to verify whether the ISO 9001 standard has an impact on the three components of intellectual capital, namely: human, structural, and relational capital.Design/methodology: Drawing on the absorptive capacity theory, the knowledge creation theory, and the sociotechnical systems theory, we developed a conceptual model that was tested on a sample of 100 Moroccan companies certified under ISO 9001.Findings: The results indicate a direct impact of the ISO 9001 standard on human capital, an indirect impact on structural capital through human capital, and finally, the ISO 9001 standard influences relational capital through a serial mediation of human and then structural capital.Originality / Value: This paper is a response to the current international debate on the importance of intellectual capital for value creation. Indeed, for intellectual capital to create value, it must be developed, and ISO 9001 standard precisely enables this development, as demonstrated by the results. Considering that more than a million organizations hold ISO 9001 certification worldwide, this aligns with the international scope of the debate on intellectual capital.
Physical and Medical Dimensions of Borderline Personality Disorder and the Effect of Treatment
Authors: Gabbard Glen O. , Ball Valdesha L. 
Published: July 2024

CME Educational Objectives

1.
Review the long-term physiological consequences of early interpersonal trauma.

2.
Identify the current neurobiological models of borderline personality disorder (BPD).

3.
List the current treatment strategies for BPD in terms of measurable effectiveness.