bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unraveling the relationship between gut microbiota and site-specific endometriosis: a Mendelian randomization analysis
Authors: Tang Yuanyuan , Yang Jiangbing , Hang Fu , Huang Hui , Jiang Li 
Published: July 2024

BackgroundAlthough numerous studies have illustrated the connection between gut microbiota and endometriosis, a conspicuous gap exists in research focusing on the pathogenesis of endometriosis at various sites and its linkage with infertility.MethodsIn this study, we used a two-sample Mendelian randomization analysis to investigate the effect of gut microbiota on the development of endometriosis in different regions, including the uterus, ovary, fallopian tube, pelvic peritoneum, vagina, and rectovaginal septum, as well as the intestine. Additionally, we explored the correlation between gut microbiota and endometriosis-induced infertility. Genetic associations with gut microbes were obtained from genome-wide association study (GWAS) datasets provided by the MiBioGen consortium, whereas endometriosis-related GWAS data were sourced from the FinnGen dataset. In our analysis, single-nucleotide polymorphisms were used as instrumental variables, with the primary estimation of the causal effect performed via the inverse variance weighting method. Our sensitivity analyses incorporated heterogeneity tests, pleiotropy tests, and the leave-one-out method.ResultsWe identified associations at the genus level between four bacterial communities and endometriosis. Subsequently, several associations between the gut microbiota and various subtypes of endometriosis at different anatomical sites were recognized. Specifically, three genera were linked with ovarian endometriosis, six genera were associated with tubal endometriosis, four genera showed links with pelvic peritoneum endometriosis, five genera were connected with vaginal and rectovaginal septum endometriosis, and seven genera demonstrated linkages with intestinal endometriosis. Additionally, one genus was associated with adenomyosis, and three genera exhibited associations with endometriosis-induced infertility.ConclusionOur study elucidates associations between gut microbiota and site-specific endometriosis, thereby augmenting our understanding of the pathophysiology of endometriosis. Moreover, our findings pave the way for potential therapeutic strategies targeting gut microbiota for individuals grappling with endometriosis-related infertility.
A bibliometric study of global trends in T1DM and intestinal flora research
Authors: Cui Xinxin , Wu Zhen , Zhou Yangbo , Deng Longji , Chen Yu , Huang Hanqiao , Sun Xiangbin , Li Yu , Wang Haixia , Zhang Li , He Jia 
Published: July 2024

BackgroundType 1 diabetes mellitus (T1DM) is a chronic metabolic disease that seriously jeopardizes human physical and mental health and reduces quality of life. Intestinal flora is one of the critical areas of exploration in T1DM research.ObjectiveThis study aims to explore the research hotspot and development trend of T1DM and intestinal flora to provide research direction and ideas for researchers.MethodsWe used the Web of Science (WOS) Core Collection and searched up to 18 November 2023, for articles on studies of the correlation between T1DM and intestinal flora. CiteSpace, VOSviewers and R package “bibliometrix” were used to conduct this bibliometric analysis.ResultsEventually, 534 documents met the requirements to be included, and as of 18 November 2023, there was an upward trend in the number of publications in the field, with a significant increase in the number of articles published after 2020. In summary, F Susan Wong (UK) was the author with the most publications (21), the USA was the country with the most publications (198), and the State University System of Florida (the United States) was the institution with the most publications (32). The keywords that appeared more frequently were T cells, fecal transplants, and short-chain fatty acids. The results of keywords with the most robust citation bursts suggest that Faecalibacterium prausnitzii and butyrate may become a focus of future research.ConclusionIn the future, intestinal flora will remain a research focus in T1DM. Future research can start from Faecalibacterium prausnitzii and combine T cells, fecal bacteria transplantation, and short-chain fatty acids to explore the mechanism by which intestinal flora affects blood glucose in patients with T1DM, which may provide new ideas for the prevention and treatment of T1DM.
Bidirectional two-sample Mendelian randomization analysis identifies causal associations between oxidative stress and Parkinson’s disease
Authors: Lv Lingling , Long Zhe , Tan Xuling , Qin Lixia , Yan Weiqian , Zhang Hainan , Ren Feng , Wang Chunyu 
Published: July 2024

BackgroundObservational studies have shown that oxidative stress (OS) is associated with Parkinson’s disease (PD). However, whether such observations reflect cause–effect remains largely unknown. To test this, we performed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal-effects between OS biomarkers and PD.MethodsWe selected summary statistics data for single-nucleotide polymorphisms (SNPs) associated with catalase (n = 13), glutathione peroxidases (n = 12), superoxide dismutase (n = 13), vitamin A (n = 7), vitamin C (n = 10), vitamin E (n = 12), vitamin B12 (n = 8), folate (n = 14), copper (n = 6), Zinc (n = 7), and iron (n = 23) levels, and the corresponding data for PD from the International Parkinson Disease Genomics Consortium (IPDGC, 33,674 cases and 449,056 controls). Inverse-variance weighted (IVW) MR analyses were conducted to estimate associations of OS with PD. Reverse MR analysis was further performed to predict the causal effects of PD on the above OS biomarkers.ResultsAs for PD, the IVW method suggested that the Zinc (Zn) levels was significantly associated with PD (OR = 1.107, 95% CI 1.013–1.211; p = 0.025), which is consistent with results from the weighted median analyses. Moreover, the results remained consistent and robust in the sensitivity analysis. However, there were no significant associations of catalase, glutathione peroxidases, superoxide dismutase, vitamin A, vitamin C, vitamin E, vitamin B12, folate, copper, or iron with PD. As for OS, our reverse MR analysis also did not support a causal effect of liability to PD on OS.ConclusionThe MR study supported the causal effect of Zn on PD. These findings may inform prevention strategies and interventions directed toward OS and PD.
A protein-rich meal provides beneficial glycemic and hormonal responses as compared to meals enriched in carbohydrate, fat or fiber, in individuals with or without type-2 diabetes
Authors: Ekberg Neda Rajamand , Catrina Sergiu-Bogdan , Spégel Peter 
Published: July 2024

IntroductionDiet stands as a pivotal modifiable risk factor influencing weight gain and the onset of type-2 diabetes (T2D). This study delves into the variation in glucose and regulatory pancreatic hormone levels subsequent to the consumption of meals with differing macronutrient compositions.MethodsThe cohort comprised 20 individuals diagnosed with T2D and 21 without diabetes. Participants underwent a cross-over design, consuming four isocaloric meals (600 kcal) enriched in carbohydrate, fiber, fat and protein. Plasma glucose, insulin and glucagon levels were measured at -30, and -5 min, followed by subsequent measurements every 30 min for 240 min post meal intake. Quantification of alterations in the postprandial state was accomplished through the incremental area under the curve (iAUC) and the incremental peak height for the insulin:glucagon ratio (IGR) and plasma glucose levels. The meal demonstrating the lowest responses across these variables was deemed the optimal meal.ResultsMeals rich in protein and fat, and consequently low in carbohydrate, exhibited reduced incremental peak and iAUC for both glucose and the IGR in comparison to the other meals. While the protein-enriched meal neared optimal standards, it proved less efficient for individuals without T2D and possessing a low BMI, as well as in those with T2D and poor glycemic control.ConclusionOur findings endorse the adoption of protein-enriched, low-carbohydrate meals to curtail the meal-induced anabolic hormonal response while averting excessive fluctuations in glucose levels.
Rapid genome sequencing for critically ill infants: an inaugural pilot study from Turkey
Authors: Guner Yilmaz Bengisu , Akgun-Dogan Ozlem , Ozdemir Ozkan , Yuksel Bayram , Hatirnaz Ng Ozden , Bilguvar Kaya , Ay Beril , Ozkose Gulsah Sebnem , Aydin Eylul , Yigit Ayca , Bulut Aybike , Esen Fatma Nisa , Beken Serdar , Aktas Selma , Demirel Atalay , Arcagok Baran Cengiz , Kazanci Ebru , Bingol İbrahim , Umur Ozge , Sik Guntulu , Isik Ugur , Ersoy Melike , Korkmaz Ayse , Citak Agop , Mardinoglu Adil , Ozbek Ugur , Alanay Yasemin 
Published: July 2024

IntroductionRare and ultra-rare genetic conditions significantly contribute to infant morbidity and mortality, often presenting with atypical features and genetic heterogeneity that complicate management. Rapid genome sequencing (RGS) offers a timely and cost-effective approach to diagnosis, aiding in early clinical management and reducing unnecessary interventions. This pilot study represents the inaugural use of next-generation sequencing (NGS) as a diagnostic instrument for critically ill neonatal and pediatric ICU patients in a Turkish hospital setting.MethodsTen infants were enrolled based on predefined inclusion criteria, and trio RGS was performed. The mean age of the participants was 124 days, with congenital abnormalities being the most common indication for testing. Three patients had consanguineous parents. The mean turnaround time from enrollment to delivery of results was 169 h, with a diagnostic yield of 50%.ResultsThree patients received a definitive molecular diagnosis, impacting their clinical management. Two patients benefited from the exclusion of Mendelian conditions, leading to alternative diagnoses.DiscussionThis study demonstrates the feasibility and results of RGS in Turkish hospital settings, emphasizing the importance of timely genetic diagnosis in reducing the diagnostic odyssey for families and improving patient care. Further research is needed to evaluate the cost-effectiveness and applicability of RGS in the Turkish healthcare system for children with diseases of uncertain etiology.
Piperacillin/tazobactam treatment in children: evidence of subtherapeutic concentrations
Authors: Ye Panpan , Shi Jinyi , Guo Zixuan , Yang Xinmei , Li Qian , Chen Keguang , Zhao Furong , Zhou Haiyan , Zhang Yehui , van den Anker John , Song Linlin , Zhao Wei 
Published: July 2024

ObjectivePiperacillin/tazobactam (PIP/TAZ) is used for the treatment of lower respiratory tract bacterial infections in children. This study was performed to evaluate if the current dosing regimen results in therapeutic drug concentrations.Patients and methodsPatients suspected or proven to have lower respiratory tract bacterial infection and administrated PIP/TAZ intravenously for a duration of no less than 0.5 h, q6h–q12h daily, were enrolled. Blood samples were collected, and PIP concentrations were determined by high-performance liquid chromatography. The individual predicted concentration of PIP was evaluated using the individual empirical Bayesian estimate method. The evaluated PK/PD targets included (1) 70% time when the predicted free drug concentration exceeds the minimum inhibitory concentration (fT &gt; MIC) and (2) 50% fT &gt; 4× MIC. Probability of target attainment (PTA) was assessed by the proportion of patients who reached the PK/PD targets. The PIP concentrations between different groups of patients were compared.ResultsA total of 57 samples were collected from 57 patients with a median age of 2.26 years (0.17–12.58). For the PK/PD targets of 70% fT &gt; MIC and 50% fT &gt; 4× MIC for Pseudomonas aeruginosa and Klebsiella pneumoniae, the PTA was all 0. The median Cmin of PIP was significantly higher in infants than in children, and the median Cmin after administration in q8h was significantly higher than that after administration in q12h.ConclusionThe current dose regimen of PIP/TAZ leads to extremely low plasma concentrations in most children with lower respiratory tract bacterial infections. More optimized dosing regimens or better alternative therapies need to be further explored.
Numerical analysis and experimental verification of time-dependent heat conduction under the action of ultra-short pulse laser
Authors: Wang Yan , Liu Jingting , Wang Chunyan , Fan Xinmin , Liu Zhaohong , Huang Xiaodong , Zhang Lujun , Li Sensen , Zhang Yu 
Published: July 2024

Thermal action is a crucial process in laser processing. The classical Fourier heat conduction theory, which assumes an infinite speed of heat propagation, is commonly applied to describe steady-state and mild transient thermal processes. However, under the influence of ultra-short pulse lasers, such as those with picosecond and femtosecond durations, the heat propagation speed within the material is finite and deviates from Fourier’s law. This article addresses the unique characteristics of heat conduction in materials subjected to ultra-short pulse laser exposure by integrating Fourier’s law with the Gaussian distribution of the actual pulse laser output power density and the material’s optical absorption properties. It introduces a time variable to establish a time-dependent heat conduction equation. This equation is numerically analyzed using a difference algorithm. Based on this, simulation and experimental studies on the processing of dental hard tissues with a 1064 nm ps laser were conducted. The results show that the experimental processing depths were slightly larger than the simulation results, which may be due to damage to the dental hard tissues and the thermomechanical effects during processing. The results offer a technical reference for adjusting laser parameters in the ultra-short pulse laser processing technique.
Perception of misinformation on social media among Chinese college students
Authors: Jiang Bowen , Wang Desheng 
Published: July 2024

BackgroundChinese college students predominantly use social media applications to collect information, communicate with each other, advance their education, and go shopping. Research has highlighted the spread of misinformation or fake news on social media, and this has affected college students negatively as they are the most frequent users of social media.ObjectiveThis research aims to investigate Chinese college students’ perceptions of misinformation on social media, including their views on the consequences of misinformation, insights into the reasons for its dissemination, how misinformation impacts their mental health, and their perspectives on how to control misinformation.MethodsThis study followed a qualitative approach, selecting 36 participants from 12 universities in China, collecting data through semi-structured interviews, and analyzing the data to enable thematic analysis.ResultsChinese college students are aware of the adverse impact of spreading misinformation on social media. They believe that false information is disseminated primarily due to inadequate punishment for those who intentionally spread it. Most college students lack proficiency in identifying misinformation, and they expect the government to do more to control the misinformation phenomenon. Moreover, misinformation on social media may cause Chinese college students to feel dysphoric, angry, and even depressed, thereby affecting their mental health. This research indicates that the public and government should make efforts to address the misinformation phenomenon in order to protect college students from being harmed.
Incidence and Predictors of Mortality Among Preterm Neonates Admitted to Jimma University Medical Center, Southwest Ethiopia: a Retrospective Follow-Up Study
Authors: Toma Temesgen Mohammed , Merga Hailu , Dube Lamessa 
Published: July 2024

ObjectiveThis study aimed to assess incidence and predictors of mortality among preterm neonates in Jimma University Medical Center, Southwest Ethiopia.MethodsA retrospective follow-up study was conducted among 505 preterm neonates admitted to the Neonatal Intensive Care Unit of Jimma University Medical Center from 01 January 2017, to 30 December 2019. Data were collected from medical records using a data collection checklist. Data were entered into Epi-Data 3.1 and analyzed with STATA 15. Cox-regression analysis was fitted to identify predictors of preterm neonatal mortality. Variables with p-value &lt;0.05 were declared a statistical significance.ResultThe cumulative incidence of preterm neonatal death was 25.1%. The neonatal mortality rate was 28.9 deaths (95%CI: 24.33, 34.46) per 1,000 neonate-days. Obstetric complications, respiratory distress syndrome, neonatal sepsis, perinatal asphyxia, antenatal steroid exposure, gestational age at birth, and receiving kangaroo-mother care were predictors of preterm neonatal mortality.ConclusionPreterm neonatal mortality rate was high. Hence, early detection and management of obstetric and neonatal complications, use of antenatal steroids, and kangaroo-mother care should be strengthened to increase preterm neonatal survival.
The ZcVg3 Gene Regulates the Reproduction and Lifespan of Female Zeugodacus cucurbitae (Coquillett) Mediated by Short-Term High Temperatures
Authors: Yang Shuyan , Peng Sihua , Wang Aqiang , Jia Jingjing , Wu Qianxing , Yang Xiaofeng , Zhou Shihao 
Published: July 2024

Zeugodacus cucurbitae (Coquillett) is a significant pest affecting fruit and vegetables in tropical and subtropical regions, and its development and reproduction are enhanced after exposure to short-term high-temperature stress at 45 °C. Vitellogenin (Vg) is an essential precursor of yolk protein formation in eggs and plays a vital role in the ovarian development of insects. Interfering with the Z. cucurbitae vitellogenin receptor (ZcVgR) gene in short-term high-temperature conditions decreases the fecundity of female adults, while the transcription level of the ZcVg3 gene increases. To elucidate the reproductive function of the ZcVg3 gene and the synergistic relationship among the ZcVgs genes under short-term high temperatures, this study injected siRNA to interfere with the ZcVg3 gene after subjecting Z. cucurbitae to a 1 h treatment at 45 °C and 25 °C. The expression of the ZcVg3 gene was suppressed, leading to the upregulation of the ZcVg1 and ZcVg2 genes, and the expression of the ZcVgR gene was initially decreased and then increased. Silencing the ZcVg3 gene after a 1 h treatment at 45 °C resulted in a reduction of approximately 84.7% and 75.9% in the fecundity and spawning days of female adults compared to the control. The development rate of their ovaries and the ovarian diameter significantly decreased, and their lifespan was reduced by 71%. The ZcVg3 gene plays a crucial role in the reproduction of Z. cucurbitae in short-term high-temperature conditions. The results of this study provide potential targets for the development of RNAi-based techniques for the control of Z. cucurbitae.
Primary care-based interventions for secondary prevention of opioid dependence in patients with chronic non-cancer pain taking pharmaceutical opioids: a systematic review
Authors: French Clare E , Troy David M , Dawson Sarah , Dalili Michael N , Hickman Matthew , Thomas Kyla H 
Published: July 2024

Background
Globally, almost one-third of adults with chronic non-cancer pain (CNCP) are prescribed opioids. Prevention of opioid dependence among these patients is a public health priority.

Aim
To synthesise the evidence on the effectiveness of primary care-based interventions for secondary prevention of opioid dependence in patients with CNCP who are taking pharmaceutical opioids.

Design & setting
Systematic review of randomised controlled trials (RCTs) and comparative non-randomised studies of interventions from high-income countries.

Method
We searched five databases for studies on non-tapering secondary prevention interventions, such as tools for predicting dependence, screening tools for early recognition of dependence, monitoring of prescribing or medication, and specialist support. We examined multiple outcomes, including reduction in opioid dosage. Primary analyses were restricted to RCTs with data synthesised using an effect direction plot. Risk of bias was assessed using the Cochrane risk of bias (RoB2) tool.

Results
Of 7102 identified reports, 18 studies were eligible (eight of which were RCTs). Most used multiple interventions or components. Of the seven RCTs at low risk of bias or with ‘some concerns’, five showed a positive intervention effect on at least one relevant outcome, four of which included a nurse care manager and/or other specialist support. The remaining two RCTs showed no positive effect of automated symptom monitoring and optimised analgesic management by a nurse care manager or a physician pain specialist team, or of a mobile opioid management app.

Conclusion
We identify a clear need for further adequately powered high-quality studies. The conclusions that can be drawn on the effectiveness of interventions are limited by the sparsity and inconsistency of available data.
Third Party Funds Affect the Net Income of Bank Syariah Indonesia (BSI)
Authors: Komala Adeh Ratna , Maryati Mari , Santiyani Widia , Hinggis Fatya Febrianti 
Published: July 2024

The function of the bank as a mediation in collecting and channeling public funds. The funds collected are known as third party funds.Third Party Funds are utilized to be placed in income generating posts. Bank Syariah Indonesia is a sharia-based banking that carries out this function. Third Party Funds which are dominated by wadiah contracts in Islamic Banks in Indonesia have increased. Third Party Funds if managed properly will have an impact on net income. Based on banking activities, researchers are interested in seeing the impact of third party funds on net income. This research was conducted with the aim of knowing how much influence third party funds have on the net profit of Bank Syariah Indonesia. The method used for this research is a descriptive and verificative method with a quantitative approach. The unit of analysis in this study is the Bandung branch of BSI. The analytical method uses SPSS version 23.0. The results of this study indicate that Third Party Funds have an effect on net income. BSI as one of the financial institutions to always increase third-party deposits by socializing a variety of potential deposit products. Currently, what is in demand is the wadiah contract, hoping that other products will also become a priority choice for customers so that third-party funds increase.
SISTEM KERJA KONTRAK DAN LINGKUNGAN KERJA PENGARUHNYA TERHADAP KINERJA KARYAWAN PADA PT. GRAFINDO MEDIA PRATAMA BANDUNG
Authors: Haliza Sefia Nur , Rizaldi Arjuna 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui Sistem Kerja Kontrak, Lingkungan Kerja, dan Kinerja Karyawan pada PT. Grafindo Media Pratama Bandung dan untuk mengetahui pengaruh Sistem Kerja Kontrak dan Lingkungan Kerja terhadap Kinerja Karyawan secara parsial maupun simultan pada PT. Grafindo Media Pratama Bandung. Penelitian ini menggunakan metode deskriptif dan verifikatif dengan pendekatan kuantitatif. Populasi dan sampel dalam penelitian ini berjumlah 46 responden. Metode analisis pada penelitian ini menggunakan persamaan regresi linier berganda dengan aplikasi SPSS V25 for windows. Hasil penelitian menunjukkan bahwa Sistem Kerja Kontrak, Lingkungan Kerja, dan Kinerja Karyawan secara keseluruhan termasuk kedalam kategori baik. Hasil pengujian hipotesis menunjukan bahwa Sistem Kerja Kontrak dan Lingkungan Kerja berpengaruh secara positif dan signifikan terhadap Kinerja Karyawan baik secara Parsial dan Simultan.