bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dyadic violence and readiness to change among male intimate partner violence offenders
Authors: Crane Cory A. , Schlauch Robert C. , Eckhardt Christopher I. 
Published: October 2015

AbstractBackgroundAlthough readiness to change is associated with mandated partner violence treatment compliance and subsequent violent behaviour among male offenders (e.g. Scott and Wolfe, ; Eckhardt et al., ), our understanding of the factors associated with pretreatment change remains limited. Offender research indicates that individual and dyadic violent behaviour are highly variable and that such variability may provide insight into levels of pretreatment change (Holtzworth‐Munroe and Stuart, ; Archer, ).Aims/HypothesesWe sought to examine the associations between indicators of change and individual as well as dyadic violence frequency in a sample of male partner violence offenders.MethodTo determine whether severity and perceived concordance in the use of violence among male offenders and their female partners influenced readiness to change at pretreatment, 82 recently adjudicated male perpetrators of intimate partner violence were recruited into the current study and administered measures of readiness to change violent behaviour (Revised Safe at Home Scale; Begun et al., ) as well as partner violence experiences (Revised Conflict Tactics Scale; Straus et al., ).ResultsAnalyses revealed an interaction between offender‐reported male and female violence in the prediction of pretreatment readiness to change such that greater male violence was associated with greater readiness to change among males who reported that their female partners perpetrated low, but not high, levels of violence. Consistently, greater female violence was associated with lower readiness to change only among the most violent male offenders.Conclusions and implications for clinical practiceResults provide support for the assertion that the most violent offenders may be the most resistant to partner violence intervention efforts, particularly when they perceive themselves to be victims as well. Enhanced motivational and couples programming may facilitate treatment engagement among the high‐risk group of male offenders who report concordant relationship violence. Copyright © 2015 John Wiley & Sons, Ltd.
Field‐Induced Slow Magnetic Relaxation in a Mononuclear Manganese(III)–Porphyrin Complex
Authors: Pascual‐Álvarez Alejandro , Vallejo Julia , Pardo Emilio , Julve Miguel , Lloret Francesc , Krzystek J. , Armentano Donatella , Wernsdorfer Wolfgang , Cano Joan 
Published: October 2015

AbstractWe report on a novel manganese(III)–porphyrin complex with the formula [MnIII(TPP)(3,5‐Me2pyNO)2]ClO4⋅CH3CN (2; 3,5‐Me2pyNO=3,5‐dimethylpyridine N‐oxide, H2TPP=5,10,15,20‐tetraphenylporphyrin), in which the MnIII ion is six‐coordinate with two monodentate 3,5‐Me2pyNO molecules and a tetradentate TPP ligand to build a tetragonally elongated octahedral geometry. The environment in 2 is responsible for the large and negative axial zero‐field splitting (D=−3.8 cm−1), low rhombicity (E/|D|=0.04) of the high‐spin MnIII ion, and, ultimately, for the observation of slow magnetic‐relaxation effects (Ea=15.5 cm−1 at H=1000 G) in this rare example of a manganese‐based single‐ion magnet (SIM). Structural, magnetic, and electronic characterizations were carried out by means of single‐crystal diffraction studies, variable‐temperature direct‐ and alternating‐current measurements and high‐frequency and ‐field EPR spectroscopic analysis followed by quantum‐chemical calculations. Slow magnetic‐relaxation effects were also observed in the already known analogous compound [MnIII(TPP)Cl] (1; Ea=10.5 cm−1 at H=1000 G). The results obtained for 1 and 2 are compared and discussed herein.
Sandmeyer‐Type Trifluoromethylthiolation and Trifluoromethylselenolation of (Hetero)Aromatic Amines Catalyzed by Copper
Authors: Matheis Christian , Wagner Victoria , Goossen Lukas J. 
Published: October 2015

AbstractAromatic and heteroaromatic diazonium salts were efficiently converted into the corresponding trifluoromethylthio‐ or selenoethers by reaction with Me4NSCF3 or Me4NSeCF3, respectively, in the presence of catalytic amounts of copper thiocyanate. These Sandmeyer‐type reactions proceed within one hour at room temperature, are applicable to a wide range of functionalized molecules, and can optionally be combined with the diazotizations into one‐pot protocols.
Evaluation of 122 advanced‐stage cutaneous squamous cell carcinomas by comprehensive genomic profiling opens the door for new routes to targeted therapies
Authors: Al‐Rohil Rami N. , Tarasen Ashley J. , Carlson J. Andrew , Wang Kai , Johnson Adrienne , Yelensky Roman , Lipson Doron , Elvin Julia A. , Vergilio Jo‐Anne , Ali Siraj M. , Suh James , Miller Vincent A. , Stephens Philip J. , Ganesan Prasanth , Janku Filip , Karp Daniel D. , Subbiah Vivek , Mihm Martin C. , Ross Jeffrey S. 
Published: October 2015

BACKGROUNDThe authors hypothesized that comprehensive genomic profiling of advanced‐stage cutaneous squamous cell carcinoma (cSCC) could identify genomic‐derived drug targets of therapy for patients with conventional therapy‐resistant disease.METHODSComprehensive genomic profiling of 315 cancer genes was applied to 50 ng of DNA from 122 cSCC cases for the evaluation of all classes of genomic alterations (GAs). Clinically relevant genomic alterations (CRGAs) were defined as those identifying anticancer drugs on the market or in registered clinical trials.RESULTSThere were 21 women (17%) and 101 men (83%) with a median age of 64.9 years (range, 21‐87 years). Eleven cSCC cases (9%) were histologic AJCC grade 1, 69 (57%) were grade 2, and 42 (34%) were grade 3. The primary cSCC was used for sequencing in 77 cases (63%). Metastatic lesions were sequenced in 37% of cases. There were 1120 total GAs identified (average of 9.2 GAs per tumor), with 100% of cases harboring at least 1 alteration. Of the 122 cSCCs, 107 (88%) harbored at least 1 CRGA (2.5 CRGAs per cSCC) includingNOTCH1 (43%); patched 1 (PTCH1) (11%); BRCA2 (10%); HRAS (8%); ataxia telangiectasia mutated (ATM) (7%); erb‐B2 receptor tyrosine kinase 4 (ERBB4) (7%); neurofibromatosis type 1 (NF1) (7%); erb‐B2 receptor tyrosine kinase 2 (ERBB2) (6%); phosphatidylinositol‐4,5‐bisphosphate 3‐kinase, catalytic subunit alpha (PIK3CA) (6%); cyclin D1 (CCND1) (6%); epidermal growth factor receptor (EGFR) (5%); and F‐box and WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) (5%).CONCLUSIONSIn the current study, approximately 88% of patients with cSCC were found to harbor clinically relevant GAs that have the potential to guide the treatment of patients with advanced‐stage tumors with targeted therapeutic agents. Cancer 2016;122:249–257. © 2015 American Cancer Society.
Initiation of universal tumor screening for Lynch syndrome in colorectal cancer patients as a model for the implementation of genetic information into clinical oncology practice
Authors: Cohen Stacey A. , Laurino Mercy , Bowen Deborah J. , Upton Melissa P. , Pritchard Colin , Hisama Fuki , Jarvik Gail , Fichera Alessandro , Sjoding Britta , Bennett Robin L. , Naylor Lorraine , Jacobson Angela , Burke Wylie , Grady William M. 
Published: October 2015

BACKGROUNDLynch syndrome confers a hereditary predisposition to colorectal and other cancers. Universal tumor screening (UTS) for Lynch syndrome is recommended by several professional societies, but the implementation can be complex. This article describes the evaluation, process development, and initiation of Lynch syndrome UTS at a tertiary referral cancer center.METHODSA multidisciplinary team developed the new process design. Issues in 5 themes were noted: timing, funding, second‐opinion patients, result processing, and the role of genetics providers. A committee approach was used to examine each issue for process‐improvement development.RESULTSThe issues related to testing were addressed individually for the successful implementation of UTS at the institutional level. In the conventional‐care period, 9 of 30 cases (30%) received Lynch syndrome screening, and 4 cases were referred to medical genetics. During the 6 months following the implementation of UTS, 32 of 44 patients (73%) received Lynch syndrome screening. The 13 unscreened patients all had identified reasons for nonscreening (eg, financial limitations). Ten patients were referred to medical genetics, which identified no new cases of Lynch syndrome, but a low‐risk adenomatous polyposis coli (APC) variant was detected in 1 individual.CONCLUSIONSThe implementation of effective Lynch syndrome UTS can feasibly alter practice at the institutional level. This experience with the assessment and management of issues relevant to the successful implementation of a new clinical care paradigm based on emerging technology has implications for the uptake of advances across molecular oncology into clinical practice, and this is highly relevant in the current era of rapidly evolving genomic technology. Cancer 2016;122:393–401. © 2015 American Cancer Society.
Effect of Cross‐Link Density on Carbon Dioxide Separation in Polydimethylsiloxane‐Norbornene Membranes
Authors: Hong Tao , Niu Zhenbin , Hu Xunxiang , Gmernicki Kevin , Cheng Shiwang , Fan Fei , Johnson J. Casey , Hong Eunice , Mahurin Shannon , Jiang De‐en , Long Brian , Mays Jimmy , Sokolov Alexei , Saito Tomonori 
Published: October 2015

AbstractThe development of high‐performance materials for carbon dioxide separation and capture will significantly contribute to a solution for climate change. Herein, (bicycloheptenyl)ethyl‐terminated polydimethylsiloxane (PDMSPNB) membranes with varied cross‐link densities were synthesized via ring‐opening metathesis polymerization. The developed polymer membranes show higher permeability and better selectivity than those of conventional cross‐linked PDMS membrane. The achieved performance (CO2 permeability≈6800 Barrer; CO2/N2 selectivity≈14) is very promising for practical applications. The key to achieving this high performance is the use of an in situ cross‐linking method for difunctional PDMS macromonomers, which provides lightly cross‐linked membranes. By combining positron annihilation lifetime spectroscopy, broadband dielectric spectroscopy, and gas solubility measurements, key parameters necessary for achieving excellent performance have been elucidated.
p73 is required for ependymal cell maturation and neurogenic SVZ cytoarchitecture
Authors: Gonzalez‐Cano L. , Fuertes‐Alvarez S. , Robledinos‐Anton N. , Bizy A. , Villena‐Cortes A. , Fariñas I. , Marques M.M. , Marin Maria C. 
Published: October 2015

ABSTRACTThe adult subventricular zone (SVZ) is a highly organized microenvironment established during the first postnatal days when radial glia cells begin to transform into type B‐cells and ependymal cells, all of which will form regenerative units, pinwheels, along the lateral wall of the lateral ventricle. Here, we identify p73, a p53 homologue, as a critical factor controlling both cell‐type specification and structural organization of the developing mouse SVZ. We describe that p73 deficiency halts the transition of the radial glia into ependymal cells, leading to the emergence of immature cells with abnormal identities in the ventricle and resulting in loss of the ventricular integrity. p73‐deficient ependymal cells have noticeably impaired ciliogenesis and they fail to organize into pinwheels, disrupting SVZ niche structure and function. Therefore, p73 is essential for appropriate ependymal cell maturation and the establishment of the neurogenic niche architecture. Accordingly, lack of p73 results in impaired neurogenesis. Moreover, p73 is required for translational planar cell polarity establishment, since p73 deficiency results in profound defects in cilia organization in individual cells and in intercellular patch orientation. Thus, our data reveal a completely new function of p73, independent of p53, in the neurogenic architecture of the SVZ of rodent brain and in the establishment of ependymal planar cell polarity with important implications in neurogenesis. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 730–747, 2016
An ion‐pairing, reversed‐phase liquid chromatography method to assess the cross‐contamination of cancer chemotherapy infusions prepared in a dual‐operator aseptic isolator
Authors: Brachet G. , Bruno C. , Boulay D. , Tournamille J. F. , Gyan E. , Viaud‐Massuard M. C. , Respaud R. 
Published: October 2015

Cytotoxics are usually prepared in a centralized pharmacy unit in a controlled hospital environment. Despite the rigorous operating procedures used for such preparations, contamination is theoretically possible – for example due to vial switches. Therefore products ought to be checked in order to determine whether quality control measures are adequate. Numerous strategies have been applied locally to ensure the safety of both patients and operators but the efficacy of these methodologies has not previously been examined. The aim of this study was to develop an analytical method sensitive enough to detect traces of anti‐cancer drugs, in order to evaluate cross‐contamination between infusions prepared in a dual‐operator isolator in the dedicated pharmacy unit. We developed a high performance liquid chromatography (HPLC) method with ultraviolet (UV) detection to identify and quantify the following seven drugs: 5‐Fluorouracil, Cytarabine, Gemcitabine, Irinotecan, Doxorubicin, Epirubicin, and Daunorubicin. We assessed the levels of cross‐contamination in 20 random preparations. We achieved separation of the seven drugs in less than 28 min, with a lower limit of quantification capable of detecting cross‐contamination. An assessment of 20 preparations revealed no cross‐contamination. We developed a reproducible and sensitive HPLC method which could be a potentially useful tool for use in practice. We checked the level of cross‐contamination in anti‐cancer drug infusions and confirmed that the process in current use was safe. This study is the first to assess cross‐contamination in anti‐cancer preparations. This work is the first step in an extensive programme of quality control, whose aim is to ensure the safety of both patients and operators. Copyright © 2015 John Wiley & Sons, Ltd.Key findings

Development of a reproducible and sensitive HPLC method capable of detecting seven anticancer drugs.
This method could be used alongside MS detection, to check for biological contamination of nursing and pharmacy staff with anticancer drugs.
No cross‐contamination was detected in cancer chemotherapy infusions prepared in a dual‐operator aseptic isolator.
Soil moisture response to experimentally altered snowmelt timing is mediated by soil, vegetation, and regional climate patterns
Authors: Conner Lafe G. , Gill Richard A. , Belnap Jayne 
Published: October 2015

AbstractSoil moisture in seasonally snow‐covered environments fluctuates seasonally between wet and dry states. Climate warming is advancing the onset of spring snowmelt and may lengthen the summer‐dry state and ultimately cause drier soil conditions. The magnitude of either response may vary across elevation and vegetation types. We situated our study at the lower boundary of persistent snow cover and the upper boundary of subalpine forest with paired treatment blocks in aspen forest and open meadow. In treatments plots, we advanced snowmelt timing by an average of 14 days by adding dust to the snow surface during spring melt. We specifically wanted to know whether early snowmelt would increase the duration of the summer‐dry period and cause soils to be drier in the early‐snowmelt treatments compared with control plots. We found no difference in the onset of the summer‐dry state and no significant differences in soil moisture between treatments. To better understand the reasons soil moisture did not respond to early snowmelt as expected, we examined the mediating influences of soil organic matter, texture, temperature, and the presence or absence of forest. In our study, late‐spring precipitation may have moderated the effects of early snowmelt on soil moisture. We conclude that landscape characteristics, including soil, vegetation, and regional weather patterns, may supersede the effects of snowmelt timing in determining growing season soil moisture, and efforts to anticipate the impacts of climate change on seasonally snow‐covered ecosystems should take into account these mediating factors. Copyright © 2015 John Wiley & Sons, Ltd.
Thermal performance of load‐bearing walls made of cold‐formed hollow flange channel sections in fire
Authors: Kesawan Sivakumar , Mahendran Mahen 
Published: October 2015

SummaryTypical load‐bearing light gauge steel frame (LSF) walls are made of conventional lipped channel section studs and gypsum plasterboards. Current research at the Queensland University of Technology is investigating the effects of using new thin‐walled stud sections on the fire‐resistant rating of LSF walls, in particular, the use of hollow flange channel (HFC) sections. A sound knowledge on the thermal performance of these LSF walls is essential, but expensive and time‐consuming nature of fire tests has acted as a barrier. In this study, finite element models were developed to predict the thermal performance of load‐bearing LSF walls made of HFC section studs exposed to fire on one side. The developed models were validated using the results of five full‐scale standard fire tests of LSF walls. They were then extended to perform a parametric study where the effects of stud dimensions, geometries, spacings and wall configuration were evaluated. The hot and cold flange time‐temperature profiles of HFC studs were developed as a function of the aforementioned parameters, which can be used to predict the fire resistance ratings of LSF walls. This paper presents the fire tests, and the details of the developed finite element models and the thermal performance results of LSF walls made of HFC studs. Copyright © 2015 John Wiley & Sons, Ltd.
Chromosome counts of some species of the genus Galium (Rubiaceae) from Iran
Authors: Saeidi Mehrvarz S. , Mokhtari Ghadim S. 
Published: October 2015

AbstractData on the chromosome counts of ten taxa of the genus Galium are reported from northeastern Iran. Two basic chromosome numbers, i.e. x = 10 and x = 11, as well as three ploidy levels, i.e. 2x, 4x and 6x are reported. Both diploid and polyploidy levels are observed. Aneuploidy was only observed in G. aparine. The chromosome numbers of the following taxa are counted for the first time: G. diploprion, G. humifusum, G. nigricans with 2n = 22 and G. spurium subsp. ibicinum with 2n = 20. The new data are compared with previous karyological information, and are discussed. (© 2015 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Mossy fiber sprouting and pyramidal cell dispersion in the hippocampal CA2 region in a mouse model of temporal lobe epilepsy
Authors: Häussler Ute , Rinas Katrin , Kilias Antje , Egert Ulrich , Haas Carola A. 
Published: October 2015

ABSTRACTDentate granule cells and the hippocampal CA2 region are resistant to cell loss associated with mesial temporal lobe epilepsy (MTLE). It is known that granule cells undergo mossy fiber sprouting in the dentate gyrus which contributes to a recurrent, proepileptogenic circuitry in the hippocampus. Here it is shown that mossy fiber sprouting also targets CA2 pyramidal cell somata and that the CA2 region undergoes prominent structural reorganization under epileptic conditions. Using the intrahippocampal kainate mouse model for MTLE and the CA2‐specific markers Purkinje cell protein 4 (PCP4) and regulator of G‐Protein signaling 14 (RGS14), it was found that during epileptogenesis CA2 neurons survive and disperse in direction of CA3 and CA1 resulting in a significantly elongated CA2 region. Using transgenic mice that express enhanced green fluorescent protein (eGFP) in granule cells and mossy fibers, we show that the recently described mossy fiber projection to CA2 undergoes sprouting resulting in aberrant large, synaptoporin‐expressing mossy fiber boutons which surround the CA2 pyramidal cell somata. This opens up the potential for altered synaptic transmission that might contribute to epileptic activity in CA2. Indeed, intrahippocampal recordings in freely moving mice revealed that epileptic activity occurs concomitantly in the dentate gyrus and in CA2. Altogether, the results call attention to CA2 as a region affected by MTLE‐associated pathological restructuring. © 2015 Wiley Periodicals, Inc.
Paradoxical effects of VEGF on synaptic activity partially involved in notch1 signaling in the mouse hippocampus
Authors: Yang Jiajia , Yang Chunxiao , Liu Chunhua , Zhang Tao , Yang Zhuo 
Published: October 2015

ABSTRACTIt is well known that the neuronal effects of vascular endothelial growth factor (VEGF) include modulating learning and memory, plasticity of mature neurons, and synaptic transmission in addition to neurogenesis. However, there is conflicting evidence particularly of its role in the regulation of excitatory synaptic activity. In this study, application of the patch‐clamp technique revealed that lower doses (10 and 50 ng/mL) of VEGF enhanced excitatory neurotransmission in hippocampal slices of mice through both presynaptic and postsynaptic mechanisms. However, the effects were reversed by higher doses of VEGF (>100 ng/mL), which inhibited excitatory neurotransmission via a presynaptic mechanism. These competing, concentration‐dependent effects of VEGF suggested that different pathways were involved. The involvement of the Notch1 receptor was tested in the modulation of VEGF on synaptic activity by using heterozygous Notch1+/− mice. Notch1 knockdown did not influence the inhibitory effect of high VEGF doses (200 ng/mL) but reduced the enhancement effects of low concentration of VEGF (50 ng/mL) at the postsynaptic level, which might be due to the decreased level of VEGF receptor. The results indicate that the Notch1 receptor plays a role in VEGF‐induced modulation of synaptic activity, which provides new insights into a complex VEGF/Notch signaling cross‐talk. These findings set the groundwork for understanding new mechanisms of Notch signaling and the neurotrophic effects of VEGF, which is beneficial to develop new therapeutic targets to the VEGF/Notch axis and improve current treatments for neural diseases. © 2015 Wiley Periodicals, Inc.