bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of Biflavones of Ginkgo biloba against UVB‐induced Cytotoxicity In vitro
Authors: Kim Seong‐Jin 
Published: July 2014

AbstractThe effect of Ginkgo biloba extract on Ultraviolet B (UVB) irradiated fibroblasts was examined by using a neutral red dye uptake assay and a lactic dehydrogenase (LDH) release assay. Crude extract along with individual components, including flavone‐glycosides and biflavones, were applied to cultured normal human skin fibroblasts for 12 hours, and 0, 20, 40 and 80 mJ/cm2 of UVB were irradiated. Two synthetic flavonoids, quercetin and rutin, which have polyphenol structures close to the flavonoids in Ginkgo biloba extract, were used to compare any structure‐related activity under the same conditions. At the concentrations (from 0.25 to 2 mg/ml) treated with biflavone components (isoginkgetin/ginkgetin, sciadopitysin) and quercetin, high neutral red dye uptake was detected with gradual increases in UVB irradiation. The time‐course release of LDH was determined as the cytotoxicity index (%) during 24 hours following a high dose UVB irradiation (200 mJ/cm2), and the pattern of this cytotoxicity index was similar to that of the neutral red dye uptake results. Sciadopitysin, isoginkgetin/ginkgetin and quercetin treatments lowered cytotoxicity indices to 50.81, 67.81 and 62.19%, respectively, compared to 95.38% for the untreated control. The antioxidant potential of biflavones of Ginkgo biloba could be explained on the basis of structure‐related activity; hydroxy‐ and methyl‐substitutions on the basic structure of these flavonoids played a role, as other reports have suggested.
Hemilateral Distribution of Papular Lesions on the Buttock Histologically Resembling Granuloma Gluteale Infantum
Authors: Maekawa Yoshihiro , Kiyoi Kiho , Kunitake Yuko 
Published: July 2014

AbstractTwo Japanese girls had small grouped papules on the buttocks without diaper dermatitis or bacterial or fungal infection. These granulomas spontaneously regressed over two weeks, even though oral antibiotics were administered. We discuss this variant of granuloma gluteale infantum of Tappeiner et al.
Changes in the Seasonal Dependence of Atopic Dermatitis in Japan
Authors: Uenishi Toshiaki , Sugiura Hisashi , Uehara Masami 
Published: July 2014

AbstractAlthough it has been generally accepted that seasonal aggravation of skin symptoms is a basic feature of atopic dermatitis, recent studies have suggested a decrease in the seasonal dependence of the dermatosis in European countries over the past several decades. We examined incidence of seasonal deterioration of atopic dermatitis in Japanse subjects. The study population consisted of 682 patients aged 3 to 30 years with atopic dermatitis, who visited our outpatient clinic from August 1998 through July 2000. Of these, 452 (66%) showed a seasonal aggravation of skin symptoms, and 230 (34%) had perennial deterioration. The overall incidences of exacerbation in spring, summer, autumn and winter were 25%, 19%, 11% and 36%, respectively. Further, 358 (52%) showed unpredictable and irregular exacerbations of skin symptoms every few days or weeks. These irregular worsenings were more frequent in patients who showed perennial deterioration than in those with seasonal aggravation. From a comparison of the present results with those reported in the 1960s, it became evident that a real decrease in the incidence of seasonal aggravation of atopic dermatitis has occurred over the past three decades in Japan and that the incidence of summer deterioration has greatly decreased during the same period of time.
Cutaneous Leiomyomatosis with Type 2 Segmental Involvement
Authors: Tsoitis George , Kanitakis Jean , Papadimitriou Christos , Hatzibougias Yannis , Asvesti Katerina , Happle Rudolf 
Published: July 2014

AbstractA 21‐year‐old man had histologically‐confirmed diffuse cutaneous leiomyomatosis. The lesions showed a peculiar distribution in that they predominantly involved several segments of the right side of his body; in addition, less extensive, nonsegmental lesions were present on both sides of the body. Although this case was apparently sporadic, the genetic mechanism of loss of heterozygosity provides a plausible explanation for this unusual presentation. If the patient were heterozygous for the underlying mutation, at an early developmental stage a postzygotic event of loss of heterozygosity would have given rise to a type 2 segmental involvement, resulting in pronounced lesions superimposed on the disseminated tumors of the ordinary phenotype.
Six Cases of Metastatic Malignant Melanoma with Apparently Occult Primary Lesions
Authors: Honda Sakiko , Yamamoto Osamu , Suenaga Yoshinori , Asahi Masakazu , Nakayama Kanichiro 
Published: July 2014

AbstractWe report here six cases of malignant melanoma in which metastatic lesions were detected first. Of these, two cases showed some peculiar features: one exhibited widespread subcutaneous bleeding, probably due to venous rupture, and the other case had a rare primary lesion on the penis. In the Japanese literature, there have been 46 cases of malignant melanoma in which metastatic lesions were detected prior to the initial ones. The preferential site for metastasis was the lymph node (32 cases). The primary lesion was unknown in 35 patients. The outcomes were available for 36 of the 46 patients; 23 died, including 18 who died within two years.
Acute Hemorrhagic Edema in a Four‐year‐old Japanese Boy
Authors: Fujimura Taku , Funayama Michitaka , Tagami Hachiro 
Published: July 2014

AbstractA case of acute hemorrhagic edema (AHE), a unique form of leukocytoclastic vasculitis limited only to the skin, was seen in a four‐year‐old boy. It was characterized by an abrupt onset of fever, peripheral edema, and rosette‐shaped purpuric plaques. Although the skin lesion might be confused clinically with other dermatoses such as Henoch‐Schönlein purpura, Sweet's disease and erythema multiforme, his laboratory data were normal, and the disorder follows a benign course with spontaneous resolution within one week.
Lupus Vulgaris Mimicking Lichen Simplex Chronicus
Authors: Pandhi Deepika , Reddy Belum Siva Nagi 
Published: July 2014

AbstractCutaneous tuberculosis is not an uncommon entity but it often remains undiagnosed and is inappropriately treated due to its varied presentation. We present a 42‐year‐old male with lupus vulgaris in the perianal area, who was treated as lichen simplex chronicus with steroids for two years. With four drug antitubercular treatment, the patient had a dramatic response. The case is being reported because in this HIV era with the resurgence of tuberculosis, not only will there be an increase in incidence but also more involvement of atypical sites.
Successful Treatment of a Patient with Lymphomatoid Papulosis by Methotrexate
Authors: Yazawa Noriko , Kondo Seiji , Kagaya Makiko , Yazawa Hitoshi , Minamitsuji Yasushi , Jimbow Kowichi 
Published: July 2014

AbstractWe report a case of lymphomatoid papulosis (LyP) that occurred in a 44‐year‐old Japanese male patient. Reddish papules with a small number of pustules and nodules were observed on the extremities, chest and upper back. Most lesions were also associated with central necrosis, ulceration and crusting, and regressed spontaneously within 4 to 6 weeks. Histopathological examination revealed wedge‐shaped dense cellular infiltrate in the dermis, which was mixed with large atypical lymphoid cells, small lymphocytes, eosinophils and neutrophils. These large atypical cells expressed CD30 on their cell membrane and cytoplasm. Rearrangement of the T‐cell receptor (TcR) β‐chain gene was detected in the skin lesion. Lymphadenopathy with histopathologic change similar to the skin lesions, but without TcR gene rearrangement, was found at the left inguinal area. Systemic administration of methotrexate (7.5–15.0 mg/week) was found to be dramatically effective in resolution of skin lesions and prevention of their recurrence.
Infantile Myofibromatosis with Visceral Involvement and Complete Spontaneous Regression
Authors: Hatzidaki Elefthezia , Korakaki Eftychia , Voloudaki Argyzi , Daskaloyannaki Mazia , Manoura Antonia , Giannakopoulou Christina 
Published: July 2014

AbstractInfantile myofibromatosis is an unusual mesenchymal disorder characterized by the proliferation of tumors in the skin, muscle, bone, and viscera. Two types can be distinguished; the solitary type, defined by the presence of one nodule in the skin, muscle, bone or subcutaneous tissue; and the multicentric type which can be divided into two sub‐types. In the first sub‐type the lesions are multicentric but without visceral involvement, while in the second, visceral involvement is present. The prognosis of the disease depends on whether visceral involvement is present. Solitary and multicentric nodules without visceral involvement usually have excellent prognosis with spontaneous regression of lesions within 1 to 2 years of diagnosis. On the other hand, visceral lesions are associated with a significant morbidity and mortality, resulting from vital organ obstruction, failure to thrive, or infection. Death in these cases often occurs at birth, or soon after, and is usually due to cardio‐pulmonary or gastrointestinal complications. The case being reported here, is that of a female newborn who had multiple skin, subcutaneous tissue, skeletal muscle, bone, and lung lesions immediately after bith. At the age of three years, the child is in good health, her psychomotor development is in accordance with her age group, and the lesions have completely regressed. This is a case of the multicentic type of infantile myofibromatosis with visceral involvement, where all lesions have spontaneously regressed. This is a rarity since the prognosis in the majority of such cases is poor.
A Case of Cutaneous Low‐grade Myofibroblastic Sarcoma
Authors: Chang Sung‐Eun , Choi Jee‐Ho , Sung Kyung‐Jeh , Moon Kee‐Chan , Koh Jai‐Kyoung , Lee Tae‐Jin , Ro Jae Y. , Silverman Jeffrey S. 
Published: July 2014

AbstractA 28‐year‐old woman presented with a recurrent nodule on the lower margin of her left nostril after laser surgery. Histologically, the nodule had an indistinct margin and was composed of interlacing fascicles of plump, spindled or stellate tumor cells with mild cytologic atypia. The tumor cells were revealed to be myofibroblasts by positivity to smooth muscle actin and negativity to desmin. A diagnosis of low grade myofibroblastic sarcoma (LGMS) was made.
Protruding Tumorous Angiolymphoid Hyperplasia with Eosinophilia (ALHE) of the Scalp Accompanied by Arterial Occlusion
Authors: Kobayashi Hiromi , Moriya Takuya , Tagami Hachiro 
Published: July 2014

AbstractWe report a case of an extraordinarily large tumorous form of ALHE developing on the occiput of a 57‐year‐old Japanese male. Histologically, it was characterized by increased numbers of small blood vessels, fibrosis, and lymph follicle formations with massive eosinopilia in the dermis in addition to an occluded artery in the deep dermis.
A Case of Chronic Perianal Pyoderma Treated with the Recycled Skin Graft Method
Authors: Honda Tetsuya , Tachibana Takao , Kitoh Akihiko , Onodera Kazumasa Morita Hisashi , Miyachi Yoshiki 
Published: July 2014

AbstractWe present here a case of chronic perianal pyoderma (CPP), who was treated with a novel skin graft. The patient was a 28‐year‐old male who had suffered from painful abscesses and nodules on his buttocks for over 10 years. Although the abscesses and nodules were initially restricted to one buttock, they gradually spread over both buttocks. He visited our hospital in July of 2000. He was clinically diagnosed as CPP and treated with oral doses of antibiotics. When admitted to our hospital in September of 2000, an anal fistula was also found. The operations for CPP and anal fistula were simultaneously performed. After the anal fistula treatment, the lesions of CPP were totally resected. In this procedure, we removed the epidermis and upper dermis from the excised CPP lesions and grafted them on the defects of the excised lesion. There has been no recurrence of the CPP. This operation procedure, which we call the “recycled skin graft method” is less invasive, because a donor site for the skin graft is unnecessary. We considered it to be as one of the effective treatments for CPP.
Perforating Pilomatricoma: Transepithelial Elimination or Not
Authors: Honda Yoshihide , Oh‐I Tsunao , Koga Michiyuki , Tokuda Yasumoto 
Published: July 2014

AbstractWe present a 56‐year‐old woman with a perforating pilomatricoma in the left eyebrow region. Histologically, the tumor consisted mainly of basophilic cells and shadow cells, and the tumor components were being eliminated through an ulcer with damage to the epithelial structures. In past reports of perforating pilomatricoma, this elimination pattern has often been described as transepithelial elimination. In many patients with perforating pilomatricoma, elimination is accompanied by ulceration and epithelial damage. Mehregan recently stated that elimination accompanied by epidermal necrosis and superficial ulceration constituted one form of transepithelial elimination. Epidermal necrosis and ulceration generally constitute severe damage. However, when Mehregan first proposed the concept of transepithelial elimination, it was defined as a phenomenon with relatively little or no damage to the epithelial structures, differentiating it from other types of elimination. This original definition makes transepithelial elimination a unique and interesting phenomenon, and its most important feature is that there is relatively little or no damage to the epithelial structures. Therefore, the terms “epidermal necrosis” and “ulceration” should not be used in association with transepithelial elimination. Hence, in patients with perforating pilomatricoma, the elimination of tumor components from ulcers with damage to the epithelial structures, as seen in the present case, should not be described as transepithelial elimination.
Localized Linear Scleroderma with Cutaneous Calcinosis
Authors: Yamamoto Ai , Morita Akimichi , Shintani Yoichi , Sakakibara Shigeru , Tsuji Takuo 
Published: July 2014

AbstractA 38‐year‐old woman developed sclerotic and atrophic changes of the left femur in the winter of 1976. In 1980, she was referred to our dermatology clinic and was diagnosed with localized linear scleroderma from the results of the physical examinations and the histological findings. Although several local and systemic treatments were employed over the following 10 years, the sclerotic lesion did not show any remarkable improvement. In 1991, several hard and white papules appeared in the lesion, and a biopsy specimen of these white papules revealed calcinosis.
Immunohistochemical Localization of Cathepsin L and Cystatin A in Normal Skin and Skin Tumors
Authors: Palungwachira Piti , Kakuta Mie , Yamazaki Masashi , Yaguchi Hitoshi , Tsuboi Ryoji , Takamori Kenji , Ogawa Hideoki 
Published: July 2014

AbstractCathepsin L, a cysteine proteinase, and cystatin A, an inhibitor of cysteine proteinases, are thought to regulate the invasion and metastasis of malignant cells. In this study, the expression of cathepsin L and cystatin A in skin tumors was investigated immunohistochemically in order to examine the relationship between these two enzymes in the pathophysiology of malignant cells. Formalin‐fixed and paraffin embedded specimens from normal skin, seborrheic keratoses, and squamous cell carcinomas were reacted with polyclonal antibodies against rat cathepsin L or cystatin α which cross‐react to human cathepsin L and cystatin A, respectively. The consequent immunostaining of these enzymes was observed to be strong in normal skin (4 cases) and seborrheic keratosis (6 cases). In well‐differentiated squamous cell carcinoma (SCC) (9 cases), staining for cathepsin L and cystatin A was moderately positive in differentiated tumor cells and negative in undifferentiated SCC (5 cases). The degree of staining of these enzymes was inversely correlated with the differentiation of the malignant cells. These results suggest that the immunohistochemical analysis of cathepsin L and cystatin A is a useful indicator for an aspect of malignancy in human epidermal keratinocytes.
Schnitzler's Syndrome with IgG κ Gammopathy
Authors: Akimoto Ruri , Yoshida Masami , Matsuda Rie , Miyasaka Keiichi , Itoh Masatoshi 
Published: July 2014

AbstractA Seventy‐year‐old man with a variant type of Schnitzler's syndrome is reported. Physical examination showed pruritic urticarial lesions on the extremities, arthralgia of knee joints, and intermittent fever. Laboratory investigations revealed a high level of IgG, an increased erythrocyte sedimentation rate, urinary Bence‐Jones protein, and an M‐bow in serum protein electrophoresis, which was shown to be a monoclonal IgG κ type. Histological examination showed perivascular neutrophil and lymphocytic infiltration into the upper dermis and diffuse neutrophilic infiltration in the middle dermis. One of the clinical features of typical Schnitzler's syndrome is IgM macroglobulinemia, and this is a very rare case of this syndrome with IgG gammopathy.
Primary Cutaneous T‐Cell‐Rich B‐Cell Lymphoma in a Zosteriform Distribution Associated with Epstein‐Barr Virus Infection
Authors: Watabe Hidenori , Kawakami Tamihiro , Soma Yoshinao , Baba Takako , Mizoguchi Masako 
Published: July 2014

AbstractT‐cell‐rich B‐cell lymphoma (TRBL) is a lately recognized B‐cell lymphoma variant characterized by a minor population of neoplastic B cells existing in a background of predominant polyclonal T cells. We report an 86‐year‐old man with primary cutaneous TRBL associated with Epstein‐Barr (EB) virus infection. Clinically, palpable scaly erythemas were distributed in a zosteriform pattern on the right abdomen. Histologically, massive cellular infiltrates were located in the upper‐ and mid‐dermis. Higher magnification showed that the cellular infiltration was composed mainly of abnormal mononuclear, large lymphoid cells with clear cytoplasm and scattered mitoses and small lymphocytes, which represented in excess of 75% of all the infiltrating cells. Immunohistochemical staining revealed that the large cells were positive for the B cell marker, CD20, but negative for the T cell marker, CD3. On the other hand, the small cells were positive for CD3, but negative for CD20. Polymerase chain reaction (PCR) revealed EB virus DNA in the skin lesion. Primary cutaneous TRBL has only been reported in 15 cases worldwide. To our knowledge, this is the first case of primary cutaneous TRBL in a zosteriform distribution reported in the literature and the second case of primary cutaneous TRBL associated with the EB virus infection. We postulate that the EB virus may be a contributory pathogenetic event leading to monoclonal B‐cell proliferation.
Antiphospholipid Antibody Syndrome Complicated by Grave's Disease
Authors: Takahashi Ayumi , Tamura Atsushi , Ishikawa Osamu 
Published: July 2014

AbstractThe report describes a woman with primary antiphospholipid antibody syndrome complicated with Grave's disease. Developing symptoms included a small cutaneous nodule on her finger and subsequently ecchymotic purpura on the cheeks, ears, buttocks and lower legs. Histological examinations showed thrombosed vessels in the dermis without or with hemorrhage, respectively. Laboratory investigation revealed positive lupus anticoagulant and immunogenic hyperthyroidism due to Grave's disease. There is a close relationship between the cutaneous manifestation of antiphospholipid antibody syndrome and the activities of Grave's disease and a possible link of antiphospholipid antibody syndrome with Grave's disease was suggested both by the etiology of the disease as well as the disease activity.
Peripheral Vascular Diseases Resulting from Chronic Arsenical Poisoning
Authors: Yu Hsin‐Su , Lee Chih‐Hung , Chen Gwo‐Shing 
Published: July 2014

AbstractDrinking water contaminated by arsenic remains a major public health problem. Long‐term arsenic exposure has been found to be associated with peripheral vascular diseases in a variety of studies. Reports of vascular effects of arsenic in drinking water, which span almost 100 years, have been published in Taiwan, Chile, Mexico, and China. This paper reviewed the association of peripheral vascular diseases resulting from arsenic exposure to drinking water from the clinical and pathological points of view. An endemic peripheral vascular disorder called “blackfoot disease” has been noticed in a limited area in Taiwan. This disease results in gangrene in the extremities. It has been associated with the ingestion of high concentrations of arsenic‐tainted artesian well water. Epidemiological studies confirmed a dose‐response relationship between long‐term arsenic exposure and the occurrence of blackfoot disease. Whereas arsenic has induced various clinical manifestations of vascular effects in Chile, Mexico and China, they do not compare in magnitude or severity to the blackfoot disease found in Taiwan. The pathogenesis of vascular effects induced by arsenic is still controversial. The possible mechanisms include endothelial cell destruction, arsenic‐associated atherogenesis, carotene and zinc deficiency, and/or some immunological mechanism. Microcirculatory assessments revealed that deficits of capillary blood flow and permeability exist in clinically normal skin of patients with chronic arsenical poisoning. The vascular effects of chronic arsenic poisoning may involve cardiovascular and cerebrovascular systems as well. In view of the increasing public health problems caused by arsenic exposure, vascular effects should be included in the future study of health effects of arsenic.
Profiles of Activated T Lymphocytes in Peripheral Blood of Kuwaiti Psoriasis Vulgaris Patients
Authors: Abul Habib , Mahmoud Fadia , Al‐Saleh Qassem , Khajeji Mehdi , Haines Donald 
Published: July 2014

AbstractWe have previously reported unexpected immunological features of psoriasis among Kuwaitis, suggesting novel patterns of immune reactivity contributing to the disease. To better define this phenomenon, we herein describe profiles of major populations and immunologically activated subsets of peripheral blood lymphocytes in a cohort of Kuwaiti psoriasis vulgaris patients. Whole venous blood from fifteen psoriatic and twenty eight normal, healthy subjects was analyzed by 2‐color flow cytometry for levels of major lymphocyte species and their immunologically activated subsets. When compared to normal subjects, psoriatic blood contained lower cell densities of CD2+, CD8+ (p=0.002 respectively) and B lymphocytes (CD19+) (p=0.003), with a trend toward a lower CD4+ density (p=0.072). Within each major lymphocyte population, activated lymphocytes were present at higher percentages in psoriatic than in healthy blood. These included CD4+ HLA‐DR+ (p=0.002), CD4+CD25+ (p=0.043), CD4+CD54+ (p=0.005), CD8+CD25+ (p=0.015), CD8+ HLA‐DR+ (p=0.046) and CD3+CD16+CD56+ (p=0.023) Additionally, psoriatic patients were found to have an expanded ratio of memory to naïve T cells (CD45RO+CD45RA+) relative to control subjects; this was expected on the basis of increased immune activation. Our findings are consistent with a picture of psoriasis as a disease mediated by activated lymphocytes.