bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of vertical ground reaction forces collected with one and two force plates in healthy dogs
Authors: Stejskal M. , Torres B. T. , Sandberg G. S. , Sapora J. A. , Dover R. K. , Budsberg S. C. 
Published: July 2015

SummaryObjective: To compare peak vertical force (PVF) and vertical impulse (VI) data collected with one and two force plates during the same collection time period in healthy dogs at a trot.Animals: Seventeen healthy client-owned adult dogs.Methods: Vertical ground reaction force (GRF) data were collected in a crossover study design, with four sessions on two consecutive days, and then two weeks apart (days 1, 2, 15, and 16) using both one and two force plates collection methods. A repeated measures model analysis of variance (ANOVA) was used to test for differences in force plate PVF, VI, and average time per trial (ATT) between days, weeks, and systems (1 plate versus 2 plates). Coefficients of variation for PVF and VI were also calculated separately by forelimbs and hindlimbs, plates, day, and week.Results: The time required to obtain a valid trial was significantly longer using a single force plate when compared with two force plates. Comparing GRF data for all dogs, significant differences in PVF data were found between one and two force plates, however, these differences were diminutive in absolute magnitude, and of unknown clinical importance. Examination of the coefficients of variation for PVF and VI during the different collection periods yielded similar results.Conclusions: Use of two force plates decreased trial repetition and collection time. Vertical GRF data had a similar coefficient of variation with either one or two force plates collection techniques in healthy dogs.
New Insight on the Role of Plasminogen Receptor in Cancer Progression
Authors: Kumari Seema , Malla Ramarao 
Published: July 2015

ObjectivePlasminogen system plays a crucial role in physiological and pathological events related to tissue regeneration, wound healing, immune response, angiogenesis, invasion and metastasis. It gets activated when plasminogen associates with its cell surface receptors. Latest information on some of the well-explored plasminogen receptors such as annexin II-S100A10, cytokeratin 8, α-enolase, plasminogen receptor (KT) (Plg-R(KT)) and histone H2B has been discussed in the present review. These receptors can pave the way for effective new therapeutic and diagnostic strategies to counteract malignant diseases.ConclusionThe present review concludes the key role of plasminogen receptors in extracellular matrix degradation, infiltration into surrounding tissues, neovascularization, invasion, metastasis and drug resistance. This review also discusses the possible effect of blocking these plasminogen receptors with monoclonal antibodies and DNA-based vaccination or silencing plasminogen receptor gene using small interfering RNA or short hairpin RNA to counteract cancer invasion and metastasis.
eHealth 2015 Special Issue: Impact of Electronic Health Records on the Completeness of Clinical Documentation Generated during Diabetic Retinopathy Consultations
Authors: Huber P. , Kriechbaum K. , Scholda C. , Duftschmid G. , Wrba T. , Schmidt-Erfurth U. , Mitsch C. 
Published: July 2015

SummaryBackground: Two years ago, the Diabetic Retinopathy (DRP) and Traumatology clinic of the Department of Ophthalmology and Optometrics at the Medical University of Vienna, Austria switched from paper-based to electronic health records. A customized electronic health record system (EHR-S) was implemented.Objectives: To assess the completeness of information documented electronically compared with manually during patient visits.Methods: The Preferred Practice Pattern for Diabetic Retinopathy published by the American Academy of Ophthalmology was distilled into a list of medical features grouped into categories to be assessed and documented during the management of patients with DRP. The last seventy paper-based records and all electronic records generated since the switch were analyzed and graded for the presence of features on the list and the resulting scores compared.Results: In all categories, clinical documentation was more complete in the EHR group.Conclusions: In our setting, the implementation of an EHR-S showed a statistically significant positive impact on documentation completeness.Citation: Mitsch C, Huber P, Kriechbaum K, Scholda C, Duftschmid G, Wrba T, Schmidt-Erfurth U. Impact of Electronic Health Records on the Completeness of Clinical Documentation Generated during Diabetic Retinopathy Consultations. Appl Clin Inform 2015; 6: 478–487http://dx.doi.org/10.4338/ACI-2015-03-RA-0028
Facial Affect Recognition Training Through Telepractice: Two Case Studies of Individuals with Chronic Traumatic Brain Injury
Authors: Williamson John , Isaki Emi 
Published: July 2015

The use of a modified Facial Affect Recognition (FAR) training to identify emotions was investigated with two case studies of adults with moderate to severe chronic (> five years) traumatic brain injury (TBI). The modified FAR training was administered via telepractice to target social communication skills. Therapy consisted of identifying emotions through static facial expressions, personally reflecting on those emotions, and identifying sarcasm and emotions within social stories and role-play. Pre- and post-therapy measures included static facial photos to identify emotion and the Prutting and Kirchner Pragmatic Protocol for social communication. Both participants with chronic TBI showed gains on identifying facial emotions on the static photos.
Editors' Note
Authors: Cohn Ellen R. , Cason Jana 
Published: July 2015

The Spring 2015 issue of the International Journal of Telerehabilitation (IJT) contains original research that analyzes provider perspectives on the use of telepractice to serve the families of children who are deaf or hard of hearing. Two case studies examine the utility of administering Facial Affect Training through telepractice to individuals with chronic traumatic brain injury. An article in IJT’s policy section describes the process for the formulation of the World Federation of Occupational Therapists (WFOT) international telehealth position statement for occupational therapy. The World Federation of Occupational Therapists (WFOT) consists of 84 member organizations representing over 420,000 occupational therapists internationally (WFOT, 2014). The Spring 2015 issue also contains announcements of upcoming conferences. As of May 2015, the International Journal of Telerehabilitation (IJT) is live on PubMed Central: http://www.ncbi.nlm.nih.gov/pmc/journals/2411/. Articles from all past issues were indexed, as will be the current and future issues.
Arendt on Resentment: Articulating Intersubjectivity
Authors: Hunt Grace 
Published: July 2015

ABSTRACT
This article develops an Arendtian conception of resentment and shows that resentment as a response to injustice is in fact only possible within a community of persons engaged in moral and recognitive relations. While Arendt is better known for her work on forgiveness—characterized as a creative rather than vindictive response to injury—this article suggests that Arendt provides a unique way of thinking about resentment as essentially a response to another human's subjectivity. But when injury is massive, so beyond the pale that the possibility of face-to-face human interaction is annihilated, the space for resentment is thereby destroyed. Ironically, while the absence of resentment might at first seem to be an unproblematically good thing, Arendt shows us that the loss of resentment actually signals the loss of the properly human realm.
The Gender of Silence: Irigaray on the Measureless Measure
Authors: Knowles Adam 
Published: July 2015

ABSTRACT
This article explores the gendered nature of speech and silence in ancient Greece by showing how women were denied the measure of moderation (sōphrosunē) with regard to speech. Drawing on examples from Plato and Aristotle, it shows how the voice of Greek women was associated with irreducibly contradictory qualities of being too loud, yet never silent enough. Exploring these contradictions through Plato's chōra and Irigaray's Speculum of the Other Woman, it argues that Greek women were ultimately considered essentially atopos, or out of place by virtue of their measurelessness, with great political consequences for the city.
Gender Dysphoria, Body Dysmorphia, and the Problematic of Body Modification
Authors: Bray Sean 
Published: July 2015

ABSTRACT
This article focuses on issues of gender identity and bodily integrity in the context of profound desires to modify the body. It contends that, while hormonal and surgical interventions in treating gender dysphoria must continue to be considered medically necessary for many people, we do not yet fully understand why it is justified as medically necessary for this condition and not for others with similar features. The article discusses the difference between the medical classification of “gender dysphoria” and “body dysmorphic disorder” and the notion of mental distress in embodiment. It discusses the role that gender essentialism may have played in the medical sanction of hormonal interventions and gender reassignment surgeries. Finally, it proffers the alternative justificatory criterion, following Eve Kosofsky Sedgwick, of “propriodescriptive authority” and explains why this justification, though highly subjective, provides better rational grounds for adjudicating which types of body modification can be considered medically necessary, grounds that can include, but also go well beyond, cases of gender dysphoria.
Effets des normes de genre, de l’éducation et de l’emploi sur l’autonomie décisionnelle des femmes en Afrique subsaharienne
Authors: Adjiwanou Vissého , Legrand Thomas K. 
Published: July 2015

L’autonomie des femmes a été reconnue comme une condition essentielle au développement lors de la Conférence internationale sur la population et le développement de Caire en 1994. Cette étude examine les facteurs contextuels (notamment des normes de genre légitimant la violence envers les femmes) et les facteurs individuels (dont le niveau d’instruction et le type d’emploi) sur l’autonomie décisionnelle des femmes en milieu rural au Ghana, au Kenya, en Ouganda et en Tanzanie. Elle utilise les données issues des enquêtes démographiques et de santé (EDS) de ces pays. La mesure des normes de genre à partir de la perception qu’ont les femmes de la violence domestique (d’un homme sur son épouse) dans leur communauté en recourant à l’analyse factorielle confirmatoire a donné de bons indices d’ajustement qui renforcent la validité de cette méthode. Une augmentation d’un écart-type de cette variable contextuelle est associée à un accroissement des risques pour une femme d’avoir une faible autonomie décisionnelle de 54 % au Ghana, de 45 % au Kenya, de 48 % en Ouganda et de 25 % en Tanzanie. L’instruction et le statut socioéconomique des femmes ne présentent pas la même stabilité sur l’autonomie décisionnelle des femmes. Nos résultats témoignent de la nécessité d’une politique plus globale pour renforcer l’autonomie des femmes en Afrique subsaharienne.
Alcohol Consumption in Relation to Risk and Severity of Chronic Widespread Pain: Results From a UK Population‐Based Study
Authors: Macfarlane Gary J. , Beasley Marcus 
Published: July 2015

ObjectiveTo determine whether the reported level of alcohol consumption is associated with the likelihood of reporting chronic widespread pain (CWP) and, among persons with CWP, the associated disability.MethodsIn a population‐based study in 2 areas of the UK, participants self‐completed a postal questionnaire. They were classified according to whether they met the American College of Rheumatology definition of CWP and whether the pain was disabling (Chronic Pain Grade III or IV). They reported their usual level of alcohol consumption. Potential confounding factors on which information was available included age, sex, cigarette smoking, employment status, self‐reported weight and height, and level of deprivation.ResultsA total of 13,574 persons participated (mean age 55 years, 57% women) of whom 2,239 (16.5%) had CWP; 28% reported never regularly consuming alcohol, 28% reported consuming up to 5 units/week, 20% reported 6–10 units/week, and 24% reported >10 units/week. Among persons with CWP, disability was strongly linked to level of alcohol consumption. Prevalence of disability decreased with increasing alcohol consumption up to 35 units/week (odds ratio [OR]21–35 units alcohol/week versus never drinkers 0.33 [95% confidence interval (95% CI) 0.19–0.58]) adjusted for confounders. A similar relationship was found between reporting CWP and level of alcohol consumption (adjusted OR21–35 units alcohol/week versus never drinkers 0.76 [95% CI 0.61–0.94]).ConclusionThis study has demonstrated strong associations between level of alcohol consumption and both CWP and related disabilities. However, the available evidence does not allow us to conclude that the association is causal. The strength of the associations means that specific studies to examine this potential relationship are warranted.
Multidimensional Model of Disability and Role Functioning in Rheumatoid Arthritis
Authors: Ormseth Sarah R. , Draper Taylor L. , Irwin Michael R. , Weisman Michael H. , Aréchiga Adam E. , Hartoonian Narineh , Bui Thuy , Nicassio Perry M. 
Published: July 2015

ObjectiveTo examine a model addressing the roles of rheumatoid arthritis (RA) disease burden, mood disturbance, and disability as determinants of impairments in role functioning.MethodsIn a cross‐sectional design, 103 RA patients recruited from the community to participate in a clinical trial completed assessments of self‐assessed disease burden (total joint pain and disease activity), mood disturbance (Center for Epidemiological Studies Depression Scale depressed mood, somatic symptoms, lack of positive affect, and interpersonal problems), disability (Health Assessment Questionnaire disability index gross and fine motor), and role functioning (Short Form 36 health survey physical and social). Structural equation modeling (SEM) was used to examine direct and indirect mechanisms linking disease burden to role functioning.ResultsSEM results indicated that the model had excellent fit: S‐Bχ2(30) = 38.59, P = 0.135; comparative fit index = 0.977, standardized root mean residual = 0.062, and root mean square error of approximation = 0.053. Mediational analyses demonstrated that, while disease burden was associated with poor role functioning, its effects were jointly mediated by mood disturbance and disability. After the effects of mood disturbance and disability were taken into account, the effect of disease burden on role functioning was not significant.ConclusionThe results indicate that mood disturbance and disability may serve as important pathways through which RA disease burden affects role functioning. Future longitudinal research is suggested to replicate these findings and further explore the mediational mechanisms examined in this study.
Pinensine: Die ersten antimykotischen Lantibiotika
Authors: Mohr Kathrin I. , Volz Carsten , Jansen Rolf , Wray Victor , Hoffmann Judith , Bernecker Steffen , Wink Joachim , Gerth Klaus , Stadler Marc , Müller Rolf 
Published: July 2015

AbstractLantibiotika (Lanthionin enthaltende Antibiotika) aus Gram‐positiven Bakterien wirken üblicherweise antibakteriell auf Gram‐positive Keime. Wir beschreiben hier die Aktivität und Struktur der Pinensine A (1) und B (2), der ersten aus einem natürlichen, Gram‐negativen Produzenten (Chitinophaga pinensis) isolierten Lantibiotika. Erstaunlicherweise zeigten Pinensine eine hohe Aktivität gegen zahlreiche filamentöse Pilze und Hefen, jedoch nur eine geringe antibakterielle Aktivität. Fungizide Lantibiotika wurden nach unserem Wissen bisher nicht beschrieben. Eine eingehende, bioinformatische Analyse des zugehörigen Biosynthesegenclusters bestätigte den ribosomalen Ursprung und ermöglichte die Identifizierung von weiteren Kandidatengenen, die für alle notwendigen Funktionen zur posttranslationalen Modifikation kodieren. Zusätzliche kodierte Funktionen ermöglichten die Aufstellung einer ersten Hypothese zu Biosynthese, Export, Perzeption und letztlich Import dieses interessanten Lantibiotikums.
Room‐Temperature Decarboxylative Alkynylation of Carboxylic Acids Using Photoredox Catalysis and EBX Reagents
Authors: Le Vaillant Franck , Courant Thibaut , Waser Jerome 
Published: July 2015

AbstractAlkynes are used as building blocks in synthetic and medicinal chemistry, chemical biology, and materials science. Therefore, efficient methods for their synthesis are the subject of intensive research. Herein, we report the direct synthesis of alkynes from readily available carboxylic acids at room temperature under visible‐light irradiation. The combination of an iridium photocatalyst with ethynylbenziodoxolone (EBX) reagents allowed the decarboxylative alkynylation of carboxylic acids in good yields under mild conditions. The method could be applied to silyl‐, aryl‐, and alkyl‐ substituted alkynes. It was particularly successful in the case of α‐amino and α‐oxo acids derived from biomass.
Acid‐Labile Thermoresponsive Copolymers That Combine Fast pH‐Triggered Hydrolysis and High Stability under Neutral Conditions
Authors: Zhang Qilu , Hou Zhanyao , Louage Benoit , Zhou Dingying , Vanparijs Nane , De Geest Bruno G. , Hoogenboom Richard 
Published: July 2015

AbstractBiodegradable polymeric materials are intensively used in biomedical applications. Of particular interest for drug‐delivery applications are polymers that are stable at pH 7.4, that is, in the blood stream, but rapidly hydrolyze under acidic conditions, such as those encountered in the endo/lysosome or the tumor microenvironment. However, an increase in the acidic‐degradation rate of acid‐labile groups goes hand in hand with higher instability of the polymer at pH 7.4 or during storage, thus posing an intrinsic limitation on fast degradation under acidic conditions. Herein, we report that a combination of acid‐labile dimethyldioxolane side chains and hydroxyethyl side chains leads to acid‐degradable thermoresponsive polymers that are quickly hydrolyzed under slightly acidic conditions but stable at pH 7.4 or during storage. We ascribe these properties to high hydration of the hydroxy‐containing collapsed polymer globules in conjunction with autocatalytic acceleration of the hydrolysis reactions by the hydroxy groups.
Monocarboxylate Transporter 4, Associated With the Acidification of Synovial Fluid, Is a Novel Therapeutic Target for Inflammatory Arthritis
Authors: Fujii Wataru , Kawahito Yutaka , Nagahara Hidetake , Kukida Yuji , Seno Takahiro , Yamamoto Aihiro , Kohno Masataka , Oda Ryo , Taniguchi Daigo , Fujiwara Hiroyoshi , Ejima Akika , Kishida Tsunao , Mazda Osam , Ashihara Eishi 
Published: July 2015

ObjectiveSynovial fluid pH is decreased in patients with rheumatoid arthritis (RA); however, the underlying mechanisms are unclear. We undertook this study to examine the mechanism by which synovial fluid pH is regulated and to explore the possibility of a therapeutic strategy by manipulating this mechanism.MethodsWe determined the pH and lactate concentration in synovial fluid from 16 RA patients. Cultured synovial fibroblasts (SFs) from the inflamed joints of 9 RA patients (RASFs) were examined for the expression of ion transporters that regulate intracellular and extracellular pH. The ion transporter up‐regulated in RASF lines was then suppressed in RASFs by small interfering RNA (siRNA), and the effect of transfection on viability and proliferation was investigated. Finally, we examined the therapeutic effect of electrotransfer of monocarboxylate transporter 4 (MCT4)–specific siRNA into the articular synovium of mice with collagen‐induced arthritis (CIA).ResultsSynovial fluid pH correlated inversely with both the Disease Activity Score in 28 joints using the C‐reactive protein level and the synovial fluid lactate levels. RASFs exhibited up‐regulated transcription of MCT4 messenger RNA. MCT4 exported intracellular lactate into the extracellular space. RASFs had significantly higher MCT4 protein levels than did SFs from patients with osteoarthritis. Knockdown of MCT4 induced intrinsic apoptosis of RASFs, thereby inhibiting their proliferation. Moreover, electrotransfer of MCT4‐specific siRNA into the articular synovium of mice with CIA significantly reduced the severity of arthritis.ConclusionRA activity correlated with decreased synovial fluid pH. This may be due to increased MCT4 expression in RASFs. Silencing MCT4 induced apoptosis in RASFs and reduced the severity of CIA, suggesting that MCT4 is a potential therapeutic target for inflammatory arthritis.
Brief Report: Enhancement of Patient Recruitment in Rheumatoid Arthritis Clinical Trials Using a Multi‐Biomarker Disease Activity Score as an Inclusion Criterion
Authors: van Vollenhoven Ronald F. , Bolce Rebecca , Hambardzumyan Karen , Saevarsdottir Saedis , Forslind Kristina , Petersson Ingemar F. , Sasso Eric H. , Hwang C. C. , Segurado Oscar G. , Geborek Pierre 
Published: July 2015

ObjectiveRheumatoid arthritis (RA) clinical trials often exclude patients who have low C‐reactive protein (CRP) levels, which slows enrollment into the trial. The purpose of this study was to determine whether high Multi‐Biomarker Disease Activity (MBDA) scores (>44) in RA patients with low CRP levels (≤10 mg/liter) could be used as a complement to CRP levels >10 mg/liter to enhance patient recruitment without affecting clinical trial outcomes.MethodsWe evaluated patients from the Swedish Pharmacotherapy (SWEFOT) trial, which did not include any selection criteria for CRP levels. Clinical outcomes were assessed after 3 months of methotrexate (MTX) monotherapy in MTX‐naive RA patients (n = 220) and after 3–10 months of add‐on therapy in patients who were incomplete responders to MTX alone (MTX‐IR) (n = 127). Radiographic outcomes were assessed at 1 year in all patients. Within each cohort, the outcomes were compared between patients with a CRP level of ≤10 mg/liter and an MBDA score of >44 at the start of the respective treatment interval versus those with a CRP level of >10 mg/liter.ResultsPatients with both a CRP level of ≤10 mg/liter and an MBDA score of >44 at baseline had clinical and radiographic outcomes that were comparable to those in patients with a CRP level of >10 mg/liter at baseline. This broadened definition of the inclusion criteria identified an additional 24% of patients in the MTX‐naive cohort and 47% in the MTX‐IR cohort.ConclusionPatient recruitment into RA clinical trials may be substantially enhanced, without any decrease in clinical and radiographic outcomes, by using as an inclusion criterion “a CRP level of >10 mg/liter and/or an MBDA score of >44.”