bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effect of the serotonin transporter gene and of environment on the continuity of anxiety and depression traits throughout adolescence
Authors: Nobile M. , Greco A. , Perna G. , Colombo P. , Bianchi V. , Bellina M. , Giorda R. , Monzani D. , Carlet O. , Griez E. , Molteni M. 
Published: October 2013

Aims.Many studies of various stress reactive phenotypes suggest that 5-HTTLPR short allele carriers (S-carriers) are characterised by the stable trait of negative affectivity that is converted to psychopathology only under conditions of stress. In this study, we examined the moderating role of the 5-HTTLPR on the relationship between two objective chronic risk factors, i.e. socioeconomic status (SES) and family structure, and internalising symptoms across adolescence.Methods.A multigroup path analysis was employed in a general adolescent population sample of a 5-year follow-up study.Results.Internalising problems were significantly more stable in theS-carriers. The focus on the main dimensions of internalising problems, i.e. anxiety and depression, revealed two different developmental patterns. In theS-carriers Anxiety problems seemed to be more stable and to predict a possible evolution towards the development of Depressive problems. In the long allele homozygotes (LL-subjects) the anxiety trait was significantly less stable, and, in late-adolescence, seemed to be significantly predicted by SES, suggesting a possible gene–environment interaction (G × E). Family structure seemed to play a role in a G × E perspective only until early-adolescence, while during late-adolescence SES seemed to play a pivotal role in interaction with 5-HTTLPR, with the S-allele playing a protective role.Conclusions.Future models of the developmental link between environmental adversities and internalising behaviour therefore need to consider that the effect of G × E interaction, may be associated with internalising behaviour via different mechanisms during different time frames and that shifts in the strength of this effect should be expected across development.
Experimental evidence suggests the existence of evolutionary conserved global operation principles governing microbial metabolism
Authors: Bordel Sergio 
Published: October 2013

AbstractThe search for optimization principles in microbial metabolism, such as biomass or ATP yields or growth rate optimization, has attracted substantial research efforts in the recent years. Here we use the results of C13 labeling experiments together with genome scale metabolic networks of S cerevisiae and E coli in order to assess if there are relationships between systemic variables that are present in both organisms. Strong correlations between the total flux per unit of substrate and the ATP turnover rate per unit of substrate and between the growth rate divided by the total flux and the total flux per unit of substrate were observed for both organisms. We also observed that the common assumption of biomass yield optimization is not consistent with the experiments.
Supporting Positive Employment Outcomes for Individuals With Autism Who Use AAC
Authors: McNaughton David , Richardson Laura 
Published: October 2013

Abstract
Employment is a valued transition outcome for many individuals with autism who use augmentative and alternative communication (AAC). As for anyone, a successful employment experience will require careful planning during the school years and the provision of appropriate supports in the workplace. Consideration of the individual's skills, preferences, and needed supports will play a critical role in ensuring positive workplace participation. This article will describe key strategies for supporting positive outcomes for individuals with autism who use AAC and illustrate these approaches with case examples.
Mutualists and antagonists drive among-population variation in selection and evolution of floral display in a perennial herb
Authors: Ågren Jon , Hellström Frida , Toräng Per , Ehrlén Johan 
Published: October 2013

SignificanceA prominent floral display may increase attractiveness to pollinators but also the risk of damage from herbivores. Here, we show experimentally that differences in the relative strength of interactions with grazers and pollinators could explain variation in selection on floral display among natural populations of an insect-pollinated primrose. In addition, we demonstrate that differences in selection translate into rather rapid changes in the genetic composition of local plant populations. The results indicate that interactions with mutualists and antagonists can drive adaptive differentiation not only across broad geographic scales but also among populations across relatively short distances.
Earth-viewing satellite perspectives on the Chelyabinsk meteor event
Authors: Miller Steven D. , Straka William C. , Bachmeier A. Scott , Schmit Timothy J. , Partain Philip T. , Noh Yoo-Jeong 
Published: October 2013

Significance
Satellite observations of large meteors (superbolides) offer important insight on trajectory through the atmosphere, and by extension, to orbital parameters that enable source attribution. On February 15, 2013, at 0920 local time, a superbolide exploded in the stratosphere near Chelyabinsk, Russia, issuing a large shock wave that damaged structures and injured hundreds below. The event was captured by Earth-viewing environmental satellites that provided multiangle views of the debris trail within minutes of formation. This paper documents these observations and their use to derive trajectory details. Results compare favorably with surface-based camera/video estimates, demonstrating the unconventional utility of satellites to characterize events that are more likely to occur away from a dense surface network.
Microenvironmental reprogramming by three-dimensional culture enables dermal papilla cells to induce de novo human hair-follicle growth
Authors: Higgins Claire A. , Chen James C. , Cerise Jane E. , Jahoda Colin A. B. , Christiano Angela M. 
Published: October 2013

SignificanceGrowth of de novo hair follicles in adult skin occurs by a process known as hair neogenesis. One way of initiating neogenesis is to place dermal papillae isolated from the hair follicle in contact with an overlying epidermis where they reprogram the epidermis to adopt a follicular fate. This approach, however, has not been successful using cultured human dermal papilla cells in human skin because the cells lose their ability to induce hair growth after expansion in vitro. In this paper, we demonstrate that by manipulating cell culture conditions to establish three-dimensional papilla spheroids, we restore dermal papilla inductivity. We also use several systems biology approaches to gain a comprehensive understanding of the molecular mechanisms that underlie this regenerative process.
Ultrafast folding kinetics and cooperativity of villin headpiece in single-molecule force spectroscopy
Authors: Žoldák Gabriel , Stigler Johannes , Pelz Benjamin , Li Hongbin , Rief Matthias 
Published: October 2013

Significance
Proteins are amazing nanomachines that achieve their functionality through a complex three-dimensional folding process. Some proteins can fold within microseconds. Only a few experimental techniques are available for studying folding on this timescale. In this paper, we expanded the use of single-molecule force spectroscopy toward ultrafast folding proteins. Using this technique, we demonstrate that rapid folding transitions of a single villin headpiece (HP35) can be experimentally monitored and analyzed using distribution moment analysis and autocorrelation functions. We show differences in the folding dynamics and cooperativity between wild-type HP35 and a stable mutant. Brownian dynamics simulations reproduce all key features of our experiments.
Neuroprotective Sirtuin ratio reversed by ApoE4
Authors: Theendakara Veena , Patent Alexander , Peters Libeu Clare A. , Philpot Brittany , Flores Sonia , Descamps Olivier , Poksay Karen S. , Zhang Qiang , Cailing Gabriellee , Hart Matthew , John Varghese , Rao Rammohan V. , Bredesen Dale E. 
Published: October 2013

Significance
This manuscript links ApoE4-mediated signaling with Sirtuin function. Specifically, we show that ApoE4, but not ApoE3, reduces neuroprotective SirT1 levels. Our data support the hypothesis that neuronal connectivity, as reflected in the ratios of critical mediators such as sAPPα:Aβ, SirT1:SirT2, APP:p-APP, and Tau:p-Tau, is programmatically altered by ApoE4. Thus ApoE4, SirT1/2, p-Tau, and p-APP, all may be part of a signaling network that is affected in AD, providing a model for therapeutic candidate screening in AD drug discovery. These findings offer a unique insight into the mechanism by which ApoE4 confers risk for the development of Alzheimer’s disease.
Human genome–guided identification of memory-modulating drugs
Authors: Papassotiropoulos Andreas , Gerhards Christiane , Heck Angela , Ackermann Sandra , Aerni Amanda , Schicktanz Nathalie , Auschra Bianca , Demougin Philippe , Mumme Eva , Elbert Thomas , Ertl Verena , Gschwind Leo , Hanser Edveena , Huynh Kim-Dung , Jessen Frank , Kolassa Iris-Tatjana , Milnik Annette , Paganetti Paolo , Spalek Klara , Vogler Christian , Muhs Andreas , Pfeifer Andrea , de Quervain Dominique J.-F. 
Published: October 2013

Significance
In the last decade there has been an exponential increase in knowledge about the genetic basis of complex human traits. It is not clear, however, to what extent this knowledge can be used as a starting point for drug identification, one of the central hopes of the human genome project. Here, we report that by using genomic information related to aversive memory—a trait central to posttraumatic stress disorder—we identified several potential drug targets and compounds. In a subsequent pharmacological study with one of the identified compounds, we found a drug-induced reduction of aversive memory. These findings indicate that genomic information can be used as a starting point for the identification of memory-modulating compounds.
Hyperpolarization without persistent radicals for in vivo real-time metabolic imaging
Authors: Eichhorn Tim R. , Takado Yuhei , Salameh Najat , Capozzi Andrea , Cheng Tian , Hyacinthe Jean-Noël , Mishkovsky Mor , Roussel Christophe , Comment Arnaud 
Published: October 2013

Significance
Hyperpolarization is a significant development in MRI because it allows for imaging different metabolites in real time in vivo. There are no fundamental obstacles to rapid translation of this technique. Yet, to date, it has been necessary to use persistent radicals that need to be filtered out before injection and require pharmacological tests, which slow down the overall protocol, leading to reduced sensitivity. The demonstration that it is possible to prepare purely endogenous MRI agents to probe metabolism in vivo without using any potentially toxic compounds is a substantial step forward toward clinical radiology free of side effects.
On some Diophantine systems involving symmetric polynomials
Authors: Ulas Maciej 
Published: October 2013

Let

σ

i

(

x

1

,
…
,

x

n

)
=

∑

1
≤

k

1

>

k

2

>
…
>

k

i

≤
n

x

k

1

…

x

k

i

\sigma _{i}(x_{1},\ldots , x_{n})=\sum _{1\leq k_{1}>k_{2}>\ldots >k_{i}\leq n}x_{k_{1}}\ldots x_{k_{i}}

be the

i
i

-th elementary symmetric polynomial. In this note we generalize and extend the results obtained in a recent work of Zhang and Cai. More precisely, we prove that for each

n
≥
4

n\geq 4

and rational numbers

a
,
b

a, b

with

a
b
≠
0

ab\neq 0

, the system of diophantine equations

σ

1

(

x

1

,
…
,

x

n

)
=
a
,

σ

n

(

x

1

,
…
,

x

n

)
=
b
,

\begin{equation*} \sigma _{1}(x_{1},\ldots , x_{n})=a, \quad \sigma _{n}(x_{1},\ldots , x_{n})=b, \end{equation*}

has infinitely many solutions depending on

n
−
3

n-3

free parameters. A similar result is proved for the system

σ

i

(

x

1

,
…
,

x

n

)
=
a
,

σ

n

(

x

1

,
…
,

x

n

)
=
b
,

\begin{equation*} \sigma _{i}(x_{1},\ldots , x_{n})=a, \quad \sigma _{n}(x_{1},\ldots , x_{n})=b, \end{equation*}

with

n
≥
4

n\geq 4

and

2
≤
i
>
n

2\leq i> n

. Here,

a
,
b

a, b

are rational numbers with

b
≠
0

b\neq 0

.

We also give some results concerning the general system of the form

σ

i

(

x

1

,
…
,

x

n

)
=
a
,

σ

j

(

x

1

,
…
,

x

n

)
=
b
,

\begin{equation*} \sigma _{i}(x_{1},\ldots , x_{n})=a, \quad \sigma _{j}(x_{1},\ldots , x_{n})=b, \end{equation*}

with suitably chosen rational values of

a
,
b

a, b

and

i
>
j
>
n

i>j>n

. Finally, we present some remarks on the systems involving three different symmetric polynomials.
Prediction fiber diameter of melt blowing nonwovens produced by dual slot inset blunt die with the help of physics model
Authors: Zhao Bo 
Published: October 2013

Purpose
– The purpose of this paper is to attempt to predict the fiber diameter of melt blowing nonwovens by means of physics model.

Design/methodology/approach
– The effects of the processing parameters on the fiber diameter is studied using the established physics model.

Findings
– The results show that the predicted and experimental values agree well, the physics model produces more accurate and stable predictions, which also indicates that the physics model is really an effective and available modeling method for predictors.

Originality/value
– The results show the great potential of this research for computer assisted design of the melt blowing technology.
Entrepreneurial orientation in small firms – values-attitudes-behavior approach
Authors: Sakari Soininen Juha , Puumalainen Kaisu , Sjögrén Helena , Syrjä Pasi , Durst Susanne 
Published: October 2013

Purpose
– The purpose of this paper is to examine the antecedents of entrepreneurial orientation (EO) and also apply the values-attitudes-behavior framework in the context of entrepreneurial behavior.

Design/methodology/approach
– A quantitative approach is used to test the hypothesis. The paper employs empirical survey data and partial least squares path modeling in the analyses.

Findings
– The analyses reveal that owner-manager's intrinsic work values are strongest drivers of innovative and proactive behaviors, but also other work values are related to EO. Furthermore, growth-oriented attitude is positively related to innovativeness and proactiveness, while more survival-oriented managers exhibit less risk-taking behavior.

Research limitations/implications
– In this exploratory study the authors did not control for sector differences. Yet, as sector characteristics may influence the drivers of EO behavior.

Practical implications
– The paper provides implications for policy makers and practitioners. Entrepreneurial activities and start-ups play a crucial role in many countries as they are vital for economic growths and the countries’ well-being. Given this importance any effective public policy intended to promote new firm creation or entrepreneurial growth of existing small businesses will have to recognize the heterogeneity of entrepreneurs and identify the potential or existing entrepreneurs who are likely to be affected by such policies.

Originality/value
– The paper is one of the first works linking the entrepreneur's work values and attitudes to EO.
A review of quick-release harness performance in water rescue
Authors: Onions Chris , Collins Loel 
Published: October 2013

Purpose
– The purpose of this paper is to consider the performance of quick-release harness buoyancy aids in water rescue.

Design/methodology/approach
– The assumption is questioned that the performance of water rescue harnesses, in what is perceived as benign, low-flow conditions (<1.85 km/s) is acceptable. Increasingly, rescue personnel are deployed to flooding events during which low-flow, but high-hazard conditions may prevail. A range of commercially available buoyancy aids manufactured in the UK were tested under “real world conditions” and the nature of the release rated.

Findings
– The primary data illustrate that 25 per cent of releases where incomplete in low-flow conditions. By analogy a karabiner in a rope rescue system with a 1:4 chance of failure would be unacceptable. Consequently, harness testing, design, manufacture, use and deployment may all be in need of reconsideration if the harness is to remain suitable for its current deployment.

Originality/value
– A group of international experts from the USA, Europe and the UK have reviewed the findings and highlight possible reasons for these failures. These comments form the basis for research in future papers.
Lean manufacturing and Six Sigma based on Brazilian model “PNQ”
Authors: M.S. Campos Lucila 
Published: October 2013

Purpose
– This paper aims to show the main results of an implementation of a tool developed to assess the integrated elements originated from lean manufacturing and Six Sigma, based on Programa Nacional da Qualidade – Brazilian National Quality Program (PNQ).

Design/methodology/approach
– This is an applied and qualitative research, which used basic qualitative studies and descriptive techniques as research strategies. A five-point Likert scale was used for the evaluation of the elements and constructs. The instrument was applied in one manufacturing company located in the Southern region of Brazil.

Findings
– The application of the instrument showed that the use of an instrument like that can be useful in the management of elements and constructs of companies that have the lean manufacturing and Six Sigma implemented. In the case of this company, among the nine constructs, three of them need more attention: strategy, culture and customer.

Research limitations/implications
– Because it is a research by means of a case study, the results cannot be generalized and should be applied in other organizations. Thus, their results could be further explored and discussed.

Practical implications
– The results point out relevant aspects related to the evaluation of integrated elements of Lean Sigma and the importance of a tool to manage them in order to reduce costs and others resources.

Originality/value
– As the application of Lean Sigma is relatively recent and there are little data published about its utilization in a developing country, it is important to expand knowledge on this subject.
Best practices in mentoring: complexities and possibilities
Authors: Brondyk Susan , Searby Linda 
Published: October 2013

Purpose– The purpose of this paper is to describe the complexity that underlies categorizing best practices in the field of mentoring. A further purpose is to propose a way to deal with this issue in order to begin to develop and identify research-based best practices in mentoring in education.Design/methodology/approach– This is a conceptual paper proposing a structure for identifying best practices in mentoring.Findings– The field of mentoring is replete with suggestions about best practices in education, but many are unsubstantiated by empirical research. The authors believe this is due in part to the breath of mentoring resulting in the use of so many different terms, conceptualizations, and applications that it is difficult for practitioners to converse about mentoring and for researchers to synthesize what is already known. They suggest an additional problem is the ambiguity regarding the term best practice. The authors cite these challenges and offer suggests for defining best practices and synthesizing the literature across contexts.Originality/value– The value of the paper is in the awareness it creates and in the possibilities it presents. By outlining the complex factors related to mentoring best practices, scholars will better understand the constraints that limit our ability to harness all that is known about mentoring best practices. Further, the authors offer a unique way to approach this task, utilizing a collaborative team approach across contexts.
Customer value assessment of pharmaceutical marketing in Taiwan
Authors: Chuang Yi-Fei , Chia Shui-Hui , Yih Wong Jehn 
Published: October 2013

Purpose– The purpose of this study is to provide a data mining approach for classifying Taiwanese healthcare institutions based on customer value assessment. Each institution type has developed its own marketing strategy along with relationship management strategies.Design/methodology/approach– Real transaction data from 88 pharmaceutical companies were the study samples. Expert interviews were conducted to analyze industry knowledge. The frequency, money, and contract term (FMC) model was developed to assess and segment the healthcare institutions. ANOVA and the Scheffe post-test were used to explore the test effects of each FMC indicator among the groups. The C5.0 decision tree was then used to generate the behavioral rules of various segmentations. Finally, this study combined the related variables with the purchasing behavioral rules to propose specific strategies for each type of healthcare institution.Findings– A total of 663 health care institutions in Taiwan were divided into four types: loyalist, intellectualist, nitpicking, and churn. The terms frequency (F), money (M) and contract term (C) were all significant indicators for determining the differences among the four customer categories at the 0.01 level of significance. The behavioral rules related to the four categories were determined by using the C5.0 algorithm.Originality/value– This FMC model can provide a strategic development method for the pharmaceutical industry to conduct market segmentation. The findings may assist pharmaceutical companies provide customized services to health care institutions and to manage their downstream demand effectively.
Will “smarter” marketing end social discrimination? A critical review
Authors: Grodzinsky Frances , Gumbus Andra , Lilley Stephen 
Published: October 2013

Purpose– There are two claims made by the web marketing/advertising industry. By collecting, managing, and mining data, companies serve consumer's best interests, and by adopting sophisticated analytics, web marketers avoid discriminations that disserve individuals. Although the paper shares an interest in ending social discrimination, the paper is more circumspect about pronounced individualism and technological fixes. Despite its appeal, or perhaps because of it, the paper should not accept the claim at face value. The paper argues that social discrimination may not disappear under smarter marketing; more overt forms may wane only to be replaced by more subtle forms. The paper aims to discuss these issues.Design/methodology/approach– The paper compares the two most important techniques of “smarter” marketing – predictive analytics and Facebook's social graph – with current discriminatory practices of weblining and e-scoring. While noting advances against overt discrimination, the paper describes how smarter marketing allows for covert forms.Findings– Innovative strategies to record and mine users' tastes and social connectivity for marketing purposes open the way for covert social discrimination.Originality/value– The paper provides a critical assessment of two claims made by the web marketing/advertising industry: by monitoring consumer web activity and collecting, managing, and mining data, companies serve consumer's best interests, and by adopting sophisticated analytics, web marketers avoid discriminations that disserve individuals.