bluuebunny/crossref_metadata_2025_split huggingface dataset:
Understanding Solidification of Polythiophene Thin Films during Spin-Coating: Effects of Spin-Coating Time and Processing Additives
Authors: Na Jin Yeong , Kang Boseok , Sin Dong Hun , Cho Kilwon , Park Yeong Don 
Published: August 2015

AbstractSpin-coating has been used extensively in the fabrication of electronic devices; however, the effects of the processing parameters have not been fully explored. Here, we systematically characterize the effects of the spin-coating time on the microstructure evolution during semiconducting polymer solidification in an effort to establish the relationship between this parameter and the performances of the resulting polymer field-effect transistors (FETs). We found that a short spin-coating time of a few seconds dramatically improve the morphology and molecular order in a conjugated polymer thin film because the π-π stacking structures formed by the polymer molecules grow slowly and with a greater degree of order due to the residual solvent present in the wet film. The improved ordering is correlated with improved charge carrier transport in the FETs prepared from these films. We also demonstrated the effects of various processing additives on the resulting FET characteristics as well as on the film drying behavior during spin-coating. The physical properties of the additives are found to affect the film drying process and the resulting device performance.
Fabrication of Microfluidic Valves Using a Hydrogel Molding Method
Authors: Sugiura Yusuke , Hirama Hirotada , Torii Toru 
Published: August 2015

AbstractIn this paper, a method for fabricating a microfluidic valve made of polydimethylsiloxane (PDMS) using a rapid prototyping method for microchannels through hydrogel cast molding is discussed. Currently, the valves in microchannels play an important role in various microfluidic devices. The technology to prototype microfluidic valves rapidly is actively being developed. For the rapid prototyping of PDMS microchannels, a method that uses a hydrogel as the casting mold has been recently developed. This technique can be used to prepare a three-dimensional structure through simple and uncomplicated methods. In this study, we were able to fabricate microfluidic valves easily using this rapid prototyping method that utilizes hydrogel cast molding. In addition, we confirmed that the valve displacement could be predicted within a range of constant pressures. Moreover, because microfluidic valves fabricated using this method can be directly observed from a cross-sectional direction, we anticipate that this technology will significantly contribute to clarifying fluid behavior and other phenomena in microchannels and microfluidic valves with complex structures.
Social, spatial and temporal organization in a complex insect society
Authors: Quevillon Lauren E. , Hanks Ephraim M. , Bansal Shweta , Hughes David P. 
Published: August 2015

AbstractHigh-density living is often associated with high disease risk due to density-dependent epidemic spread. Despite being paragons of high-density living, the social insects have largely decoupled the association with density-dependent epidemics. It is hypothesized that this is accomplished through prophylactic and inducible defenses termed ‘collective immunity’. Here we characterise segregation of carpenter ants that would be most likely to encounter infectious agents (i.e. foragers) using integrated social, spatial and temporal analyses. Importantly, we do this in the absence of disease to establish baseline colony organization. Behavioural and social network analyses show that active foragers engage in more trophallaxis interactions than their nest worker and queen counterparts and occupy greater area within the nest. When the temporal ordering of social interactions is taken into account, active foragers and inactive foragers are not observed to interact with the queen in ways that could lead to the meaningful transfer of disease. Furthermore, theoretical resource spread analyses show that such temporal segregation does not appear to impact the colony-wide flow of food. This study provides an understanding of a complex society’s organization in the absence of disease that will serve as a null model for future studies in which disease is explicitly introduced.
Parity and Cardiovascular Disease Mortality: a Dose-Response Meta-Analysis of Cohort Studies
Authors: Lv Haichen , Wu Hongyi , Yin Jiasheng , Qian Juying , Ge Junbo 
Published: August 2015

AbstractParity has been shown to inversely associate with cardiovascular disease (CVD) mortality, but the evidence of epidemiological studies is still controversial. Therefore, we quantitatively assessed the relationship between parity and CVD mortality by summarizing the evidence from prospective studies. We searched MEDLINE (PubMed), EMBASE and ISI Web of Science databases for relevant prospective studies of parity and CVD mortality through the end of March 2015. Fixed- or random-effects models were used to estimate summary relative risks (RRs) and 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I2 statistics. All statistical tests were two-sided. Ten prospective studies were included with a total of 994,810 participants and 16,601 CVD events. A borderline significant inverse association was observed while comparing parity with nulliparous, with summarized RR = 0.79 (95% CI: 0.60–1.06; I2 = 90.9%, P < 0.001). In dose-response analysis, we observed a significant nonlinear association between parity number and CVD mortality. The greatest risk reduction appeared when the parity number reached four. The findings of this meta-analysis suggests that ever parity is inversely related to CVD mortality. Furthermore, there is a statistically significant nonlinear inverse association between parity number and CVD mortality.
Pathway-Based Genome-wide Association Studies Reveal That the Rac1 Pathway Is Associated with Plasma Adiponectin Levels
Authors: Li Wei-Dong , Jiao Hongxiao , Wang Kai , Yang Fuhua , Grant Struan F. A. , Hakonarson Hakon , Ahima Rexford , Arlen Price R. 
Published: August 2015

AbstractPathway-based analysis as an alternative and effective approach to identify disease-related genes or loci has been verified. To decipher the genetic background of plasma adiponectin levels, we performed genome wide pathway-based association studies in extremely obese individuals and normal-weight controls. The modified Gene Set Enrichment Algorithm (GSEA) was used to perform the pathway-based analyses (the GenGen Program) in 746 European American females, which were collected from our previous GWAS in extremely obese (BMI > 35 kg/m2) and never-overweight (BMI<25 kg/m2) controls. Rac1 cell motility signaling pathway was associated with plasma adiponectin after false-discovery rate (FDR) correction (empirical P < 0.001, FDR = 0.008, family-wise error rate = 0.008). Other several Rac1-centered pathways, such as cdc42racPathway (empirical P < 0.001), hsa00603 (empirical P = 0.003) were among the top associations. The RAC1 pathway association was replicated by the ICSNPathway method, yielded a FDR = 0.002. Quantitative pathway analyses yielded similar results (empirical P = 0.001) for the Rac1 pathway, although it failed to pass the multiple test correction (FDR = 0.11). We further replicated our pathway associations in the ADIPOGen Consortium data by the GSA-SNP method. Our results suggest that Rac1 and related cell motility pathways might be associated with plasma adiponectin levels and biological functions of adiponectin.
Curcumin as therapeutics for the treatment of head and neck squamous cell carcinoma by activating SIRT1
Authors: Hu An , Huang Jing-Juan , Li Rui-Lin , Lu Zhao-Yang , Duan Jun-Li , Xu Wei-Hua , Chen Xiao-Ping , Fan Jing-Ping 
Published: August 2015

AbstractSIRT1 is one of seven mammalian homologs of Sir2 that catalyzes NAD+-dependent protein deacetylation. The aim of the present study is to explore the effect of SIRT1 small molecule activator on the anticancer activity and the underlying mechanism. We examined the anticancer activity of a novel oral agent, curcumin, which is the principal active ingredient of the traditional Chinese herb Curcuma Longa. Treatment of FaDu and Cal27 cells with curcumin inhibited growth and induced apoptosis. Mechanistic studies showed that anticancer activity of curcumin is associated with decrease in migration of HNSCC and associated angiogenesis through activating of intrinsic apoptotic pathway (caspase-9) and extrinsic apoptotic pathway (caspase-8). Our data demonstrating that anticancer activity of curcumin is linked to the activation of the ATM/CHK2 pathway and the inhibition of nuclear factor-κB. Finally, increasing SIRT1 through small molecule activator curcumin has shown beneficial effects in xenograft mouse model, indicating that SIRT1 may represent an attractive therapeutic target. Our studies provide the preclinical rationale for novel therapeutics targeting SIRT1 in HNSCC.
Non-immune immunoglobulins shield Schistosoma japonicum from host immunorecognition
Authors: Wu Chuang , Hou Nan , Piao Xianyu , Liu Shuai , Cai Pengfei , Xiao Yan , Chen Qijun 
Published: August 2015

AbstractSchistosomiasis is a major human parasitic disease with a global impact. Schistosoma japonicum, the most difficult to control, can survive within host veins for decades. Mechanisms of immune evasion by the parasite, including antigenic variation and surface masking, have been implicated but not well defined. In this study, we defined the immunoglobulin-binding proteomes of S. japonicum using human IgG, IgM and IgE as the molecular bait for affinity purification, followed by protein identification by liquid chromatography with tandem mass spectrometry (LC-MS/MS). Several proteins situated at the tegument of S. japonicum were able to nonselectively bind to the Fc domain of host immunoglobulins, indicating a mechanism for the avoidance of host immune attachment and recognition. The profile of the immunoglobulin-binding proteomes provides further clues for immune evasion mechanisms adopted by S. japonicum.
Imaging real-time HIV-1 virion fusion with FRET-based biosensors
Authors: Jones Daniel M. , Padilla-Parra Sergi 
Published: August 2015

AbstractWe have produced a novel, simple and rapid method utilising genetically encodable FRET-based biosensors to permit the detection of HIV-1 virion fusion in living cells. These biosensors show high sensitivity both spatially and temporally and allow the real-time recovery of HIV-1 fusion kinetics in both single cells and cell populations simultaneously.
Performance evaluation of turbulence‐accentuated interchannel crosstalk for hybrid fibre and free‐space optical wavelength‐division‐multiplexing systems using digital pulse‐position modulation
Authors: Mbah Afamefuna M. , Walker John G. , Phillips Andrew J. 
Published: August 2015

A hybrid fibre and free‐space optical communication link using digital pulse‐position modulation (DPPM) in a wavelength‐division‐multiplexing system is proposed. Such a system, which could provide a power efficient, robust and flexible solution to high‐speed access networks, is a contender for a passive optical network solution and could readily be deployed in areas with restrictions in optical fibre installation, or alternatively as a disaster recovery network. Interchannel crosstalk and atmospheric turbulence are major impairments in such a system and could combine in some cases to degrade the system. Both impairments are investigated here and the results are presented in the form of bit error probability, required optical transmission power and power penalties. Depending on the position of the interferer relative to the desired user, power penalties of about 0.2–3.0 dB for weak turbulence and above 20 dB for strong turbulence regimes are reported for bit error rate of 10−6. DPPM scheme with a coding level of 2 show about 2 dB improvements over on–off‐keying scheme.
Mastoid Obliteration with Autologous Bone in Mastoidectomy Canal Wall Down Surgery: a Literature Overview
Authors: Alves Ricardo , Cabral Junior Francisco , Fonseca Anna , Bento Ricardo 
Published: August 2015

Introduction The objectives of mastoidectomy in cholesteatoma are a disease-free and dry ear, the prevention of recurrent disease, and the maintenance of hearing or the possibility to reconstruct an affected hearing mechanism. Canal wall down mastoidectomy has been traditionally used to achieve those goals with greater or lesser degrees of success. However, canal wall down is an aggressive approach, as it involves creating an open cavity and changing the anatomy and physiology of the middle ear and mastoid. A canal wall up technique eliminates the need to destroy the middle ear and mastoid, but is associated with a higher rate of residual cholesteatoma. The obliteration technics arise as an effort to avoid the disadvantages of both techniques.
Objectives Evaluate the effectiveness of the mastoid obliteration with autologous bone in mastoidectomy surgery with canal wall down for chronic otitis, with or without cholesteatoma.
Data Synthesis We analyzed nine studies of case series comprehending similar surgery techniques on 1017 total cases of operated ears in both adults and children, with at least 12 months follow-up.
Conclusion Mastoid Obliteration with autologous bone has been utilized for many years to present date, and it seems to be safe, low-cost, with low recurrence rates - similar to traditional canal wall down procedures and with greater water resistance and quality of life improvements.
Impact of futures trading on volatility of spot market-a case of guar seed
Authors: Sharma Dinesh Kumar , Malhotra Meenakshi 
Published: August 2015

Purpose– Guar Seed crop is ruling the Indian International business mainly due to its application as a drilling fluid in shale energy industry concentrated in the USA. One of the allegations against futures market is its possible role in increasing the volatility of underlying physical market prices. Suspension of guar seed futures contract in 2012 at National Commodity Derivatives Exchange of India (NCDEX)-India, has reignited the controversy and raised an alarm bell to peek into obscure world of Indian commodity derivatives market. Against the backdrop of fiasco in guar futures trading, the purpose of this paper is to investigate whether sudden surge in futures trading volume leads to increase in the volatility of spot market prices.Design/methodology/approach– Guar seed spot returns volatility is modeled as a GARCH (1, 1) process. Futures trading volume and open interest are segregated into expected and unexpected components. The data are analyzed from 2004 to 2011 using Augmented GARCH model to study the contemporaneous relationship between spot volatility and unexpected futures trading activity and Granger Causality test for examining the dynamic relationship between them and ascertaining causality.Findings– Augmented GARCH model reports positive relationship between unexpected futures trading volume (UTV) and spot returns volatility, and, Granger Causality flows from UTV to spot volatility. Therefore, when the level of futures trading volume increases unexpectedly, the volatility of spot prices increases pointing toward the destabilizing impact of futures trading. However, hedger’s activity, represented by open interest is not seen to have any causal/destabilizing impact on spot price volatility of guar seed.Practical implications– The study provides empirical evidence to support the concern of regulators, genuine hedgers and other traders about the presence of excessive speculation and market manipulations perpetrated through futures market that is disturbing the underlying physical market instead of strengthening it by aiding in price discovery and risk mitigation.Originality/value– There are very few studies which have empirically investigated the temporal relation between volume and volatility in Indian agricultural commodity markets. With guar seed as a special case the present study investigates statistically the impact of futures trading on spot price volatility. In light of the findings of the study, the curb imposed on guar seed futures trading in 2012 was justified.
Socioemotional wealth in the family farm
Authors: Dressler Jonathan B , Tauer Loren 
Published: August 2015

Purpose
– A family member may work for the family business even though the direct financial benefits he or she may receive in the form of a salary may be lower than what could be earned working for a non-family business. The lower amount may be accepted because of benefits of association with the family business. This psychic non-pecuniary return has been called socioemotional wealth in the family business research literature. The purpose of this paper is to propose a method to estimate socioemotional wealth and apply that technique to a group of family dairy farms to estimate socioemotional wealth for those family farms.

Design/methodology/approach
– A panel regression method was used to empirically allocate net farm income to the unpaid factors of equity, labor, and management provided by a family member in a family farm partnership. The estimated returns of labor plus management are compared to the market salary earned by farm managers who manage farms. The difference between the higher hired farm manager salary and what the family manager earns in the family farm from labor and management is an estimate of the non-pecuniary return the family member receives from managing the family farm as compared to managing the non-family farm.

Findings
– Differences in managers’ salary working for the non-family farm and the implied family manager financial compensation estimates indicate that family business managers’ non-pecuniary return from managing the family farm had an implied economic value averaging $22,026 per year over 1999-2008. Assuming that the manager would be indifferent between working for the family farm or the non-family farm if the sum of pecuniary and non-pecuniary returns were the same, the non-pecuniary annual benefits of $22,026 accrues in the form of socioemotional wealth associated as a member in the family business.

Originality/value
– Although the literature discusses how family members may accept a lower salary working for the family business than they could earn doing comparable work in a non-family business because of non-financial rewards they experience working for the family business, there have been no estimates of the value of this pecuniary benefit. The authors arrive at an estimate using a group of family dairy farm businesses that have multiple family managers.
Inter-organizational business process verification in public administration
Authors: Corradini Flavio , Polini Andrea , Re Barbara 
Published: August 2015

Purpose
– Public services can be modelled, analysed and implemented using notations and tools for the business process (BP) abstraction. Applying such an explicit approach public administrations (PAs) can better react to the undergoing transformation in service provisioning and they can continuously improve service quality in order to satisfy citizens and business requests, while coping with decreasing budgets. The purpose of this paper is to discuss these issues.

Design/methodology/approach
– The proposed approach relies on using formal methods, in particular unfolding to analyse the correctness of BP. The paper also compares and selects mapping rules from semi-formal to formal modelling languages; these techniques are presented in the context of the BP Modelling Languages and Petri Net (PN).

Findings
– Main aim of this paper is to raise the need for formal verification of BP governing the interactions among PAs, which more and more need to be supported by ICT mechanisms, and then are not so much tolerant to errors and imperfections in the process specification. The paper illustrates the main motivations of such a work and it introduces a verification technique of a BP using a mapping of a high-level notation (such as BPMN 2.0) to a formal notation (such as PNs) for which formal analysis techniques can be adopted. In particular the verification step is implemented using an unfolding-based technique.

Originality/value
– The paper answers a call for further development of the body of knowledge on effective analysis of BPs, a rapidly emerging field of interest for large and ultra large scenarios, where a clear gap in literature exists. Than the paper shows that formal techniques are mature enough to be applied on real scenarios.
Adopting a management innovation in a professional organization
Authors: Hellström Andreas , Lifvergren Svante , Gustavsson Susanne , Gremyr Ida 
Published: August 2015

Purpose– The purpose of this paper is to study critical practices when adopting improvement knowledge as a management innovation in a professional organization.Design/methodology/approach– This paper is based on an action research approach, in which practitioners and researchers are seen as a part of a participative community generating actionable knowledge. Research involved gathering data over a five-year period through more than 250 interviews and 25 focus groups.Findings– This paper identifies five critical practices for adopting a management innovation in a professional context: first, focussing on labeling and theorizing to create an organization’s own vocabulary; second, focussing on the role of internal change agents; third, allowing for an evolutionary adoption process; fourth, building new professional competence through the change agents; and fifth, adopting a research-driven approach to the adoption of a management innovation.Practical implications– For healthcare practitioners, this paper points to practices to consider when adopting improvement knowledge – for example, identifying the patient as the guiding principle and encouraging involvement and local change initiatives. For practitioners in other professionally driven organizations, this paper identifies critical practices for adopting a management innovation – for example, focussing on theorizing and labeling in order to create an organization’s own vocabulary related to the professional context.Originality/value– On a generic level, this paper contributes to the understanding of critical aspects when adopting management innovations in a professional organization. In a healthcare context, this paper points to the value of improvement knowledge for improving quality of care. Improvement knowledge is relatively new in healthcare, and this study provides an example of a hospital in which this management innovation helped transform the organization.