bluuebunny/crossref_metadata_2025_split huggingface dataset:
The myth of the miracle baby: how neonatal nurses interpret media accounts of babies of extreme prematurity
Authors: Green Janet , Darbyshire Philip , Adams Anne , Jackson Debra 
Published: March 2015

Improved life sustaining technology in the neonatal intensive care unit (NICU) has resulted in an increased probability of survival in extremely premature babies. Miracle baby stories in the popular press are a regular occurrence and these reports are often the first source from which the general public learn about extremely premature babies. The research from which this paper is drawn sought to explore the care‐giving and ethical dilemmas of neonatal nurses when caring for extremely premature babies 24 weeks gestation and less. This current paper aims to outline the views of neonatal nurses on miracle baby stories in the media. Data were collected via a questionnaire to 760 Australian neonatal nurses with 414 returned, representing a response rate of 54.4%. Narrative was collected from semi‐structured interviews with 24 experienced neonatal nurses in NSW, Australia. A qualitative approach utilising thematic analysis was utilised to analyse the data. The theme the myth of the miracle baby is seen as generating myths and unrealistic expectations on the part of vulnerable families and the public. Neonatal nurses, as the primary caregivers for tiny babies and their families, viewed popular media publications with suspicion, believing published reports to be incomplete, inaccurate and biased towards the positive.
Role of stress‐related hormones in plant defence during early infection of the cyst nematode Heterodera schachtii in Arabidopsis
Authors: Kammerhofer Nina , Radakovic Zoran , Regis Jully M. A. , Dobrev Petre , Vankova Radomira , Grundler Florian M. W. , Siddique Shahid , Hofmann Julia , Wieczorek Krzysztof 
Published: March 2015

Summary

Heterodera schachtii, a plant‐parasitic cyst nematode, invades host roots and induces a specific syncytial feeding structure, from which it withdraws all required nutrients, causing severe yield losses. The system H. schachtii–Arabidopsis is an excellent research model for investigating plant defence mechanisms. Such responses are suppressed in well‐established syncytia, whereas they are induced during early parasitism. However, the mechanisms by which the defence responses are modulated and the role of phytohormones are largely unknown.

The aim of this study was to elucidate the role of hormone‐based defence responses at the onset of nematode infection. First, concentrations of main phytohormones were quantified and the expression of several hormone‐related genes was analysed using quantitative real‐time (qRT)‐PCR or GeneChip. Further, the effects of individual hormones were evaluated via nematode attraction and infection assays using plants with altered endogenous hormone concentrations.

Our results suggest a pivotal and positive role for ethylene during nematode attraction, whereas jasmonic acid triggers early defence responses against H. schachtii. Salicylic acid seems to be a negative regulator during later syncytium and female development.

We conclude that nematodes are able to impose specific changes in hormone pools, thus modulating hormone‐based defence and signal transduction in strict dependence on their parasitism stage.
Implementation of intersectoral community approaches targeting childhood obesity: a systematic review
Authors: van der Kleij R. , Coster N. , Verbiest M. , van Assema P. , Paulussen T. , Reis R. , Crone M. 
Published: March 2015

SummaryThe implementation of intersectoral community approaches targeting childhood obesity (IACO) is considered challenging. To help overcome these challenges, an overview of the evidence to date is needed. We searched four databases to identify papers that reported on the determinants of successful implementation of IACOs, resulting in the inclusion of 25 studies. We appraised study quality with the Crowe Critical Appraisal Tool and the Quality Framework; reported implementation outcome indicators were reviewed via narrative synthesis. Quality of included studies varied. The most frequently reported indicators of implementation success were fidelity and coverage. Determinants related to the social‐political context and the organization were most often cited as influencing implementation, in particular, ‘collaboration between community partners’, ‘the availability of (human) resources’ and ‘time available for implementation’. The association between determinants and implementation variability was never explicated. We conclude that although some insights into the effective implementation of IACOs are present, more research is needed. Emphasis should be placed on elucidating the relationship between determinants and implementation success. Research should further focus on developing a ‘golden standard’ for evaluating and reporting on implementation research. These actions will improve the comparison of study outcomes and may constitute the cumulative development of knowledge about the conditions for designing evidence‐based implementation strategies.
Effect of orthodontic treatment with preadjusted edgewise appliances on the buccolingual inclination of mandibular canines: a CBCT study
Authors: Hamdan H. A. , Grünheid T. , Larson B. E. 
Published: March 2015

Structured AbstractObjectivesTo assess the effects of treatment with preadjusted edgewise appliances on the buccolingual inclination of mandibular canines and the intercanine distance.Setting and Sample PopulationThe Division of Orthodontics at the University of Minnesota. Thirty patients whose treatment included extraction of mandibular first premolars and 30 patients whose treatment did not include extractions.Material and MethodsThe buccolingual inclination of mandibular canines and their linear distance were measured on cone beam computed tomograms before and after treatment in both patient groups. Differences between extraction and non‐extraction groups and between pre‐ and post‐treatment measurements were tested for statistical significance, and the correlation between the buccolingual inclination and the intercanine distance was computed.ResultsPost‐treatment, the buccolingual inclination of mandibular canines was significantly greater in the non‐extraction group than in the extraction group. In both groups, the canines became more lingually inclined with treatment (non‐extraction group: −2.1°; extraction group: −4.1°). The intercanine distance increased significantly in the extraction group (+1.2 mm) but not in the non‐extraction group (−0.5 mm). While there was a significant positive correlation between the buccolingual inclination and the mandibular intercanine distance in both groups before treatment, after treatment this correlation was significant only in the non‐extraction group.ConclusionOrthodontic treatment with preadjusted edgewise appliances results in more lingually inclined mandibular canines together with an increased intercanine distance, especially in patients whose treatment involves the extraction of mandibular first premolars.
NF1 loss induces senescence during human melanocyte differentiation in an iPSC‐based model
Authors: Larribere Lionel , Wu Huizi , Novak Daniel , Galach Marta , Bernhardt Mathias , Orouji Elias , Weina Kasia , Knappe Nathalie , Sachpekidis Christos , Umansky Ludmila , Beckhove Philipp , Umansky Viktor , De Schepper Sofie , Kaufmann Dieter , Ballotti Robert , Bertolotto Corine , Utikal Jochen 
Published: March 2015

SummaryNeurofibromatosis type 1 (NF1) is a frequent genetic disease leading to the development of Schwann cell‐derived neurofibromas or melanocytic lesions called café‐au‐lait macules (CALMs). The molecular mechanisms involved in CALMs formation remain largely unknown. In this report, we show for the first time pathophysiological mechanisms of abnormal melanocyte differentiation in a human NF1+/−‐induced pluripotent stem cell (iPSC)‐based model. We demonstrate that NF1 patient‐derived fibroblasts can be successfully reprogrammed in NF1+/− iPSCs with active RAS signaling and that NF1 loss induces senescence during melanocyte differentiation as well as in patient's‐derived CALMs, revealing a new role for NF1 in the melanocyte lineage.
Two Novel Homozygous Desmoplakin Mutations in Carvajal Syndrome
Authors: Molho‐Pessach Vered , Sheffer Sivan , Siam Rula , Tams Spiro , Siam Ihab , Awwad Rula , Babay Sofia , Golender Julius , Simanovsky Natalia , Ramot Yuval , Zlotogorski Abraham 
Published: March 2015

AbstractBackgroundMutations in various desmosomal proteins were shown to cause inherited forms of cardiomyopathy. Carvajal syndrome (Online Mendelian Inheritance in Man [OMIM] 605676) is characterized by the association of dilated cardiomyopathy, striate palmoplantar keratoderma, and woolly hair. It is caused by homozygous as well as heterozygous mutations in DSP, which encodes the desmosomal plaque protein desmoplakin. An overlapping cardiocutaneous phenotype was also described with homozygous mutations in genes encoding two other desmosomal proteins; plakoglobin (Naxos disease; OMIM 601214) and desmocollin‐2 (OMIM 610476).MethodsWe performed clinical and molecular workups in two consanguineous Arab Palestinian families manifesting an autosomal recessive pattern of inheritance of the above mentioned clinical findings. Whole exome sequencing was employed in the search for the causing mutation.ResultsAffected family members suffered from biventricular involvement and arrhythmogenic right ventricular dysplasia based on echocardiography and magnetic resonance imaging. One patient who underwent implantation of an implantable cardioverter‐defibrillator (ICD) is still alive at the age of 59 years. Whole exome sequencing revealed two novel homozygous mutations in DSP, each affecting one family.ConclusionsThe association of woolly hair with palmoplantar keratoderma in a child should lead to a cardiac workup in the search for those at increased risk for sudden cardiac death. Early diagnosis and ICD implantation may be lifesaving. Whole exome sequencing should be utilized for rapid genetic analysis since the cardiocutaneous phenotype may result from mutations in one of several genes.
Cutaneous Disease in Autism Spectrum Disorder: A Review
Authors: Accordino Robert E. , Lucarelli Jennifer , Yan Albert C. 
Published: March 2015

AbstractDermatologic comorbid symptoms and conditions in persons with autism spectrum disorder (ASD) are compelling for several reasons, including problems with tactile sensory dysfunction in this population, a large number of syndromes with dermatologic findings and high rates of autism, nutritional and hormonal problems in ASD and their dermatologic manifestations, and the potential for overrepresentation of dermatologic symptoms that are neurobehavioral in nature. The current article reviews the available literature on the prevalence of comorbid dermatologic symptoms and conditions in children with ASD and identifies strategies for diagnosing and managing cutaneous disease in this population.
Is the noun ending a cue to grammatical gender processing? An ERP study on sentences in Italian
Authors: Caffarra Sendy , Siyanova‐Chanturia Anna , Pesciarelli Francesca , Vespignani Francesco , Cacciari Cristina 
Published: March 2015

AbstractGender‐to‐ending consistency has been shown to influence grammatical gender retrieval in isolated word presentation. Notwithstanding the wealth of evidence, the exact role and the time course of processing of this distributional information remain unclear. This ERP study investigated if and when the brain detects gender‐to‐ending consistency in sentences containing Italian determiner‐noun pairs. Determiners either agreed or disagreed in gender with the nouns whose endings were reliable or misleading cues to gender (transparent and irregular nouns). Transparent nouns elicited an increased frontal negativity and a late posterior positivity compared to irregular nouns (350–950 ms), suggesting that the system is sensitive to gender‐to‐ending consistency from relatively early stages of processing. Gender agreement violations evoked a similar LAN‐P600 pattern for both types of nouns. The present findings provide evidence for an early detection of reliable gender‐related endings during sentence reading.
New scoring system for the differentiation of chronic obstructive pulmonary disease and asthma
Authors: Lee Young Seok , Baek Seunghee , Ko Yousang , Kim Mi‐Yeong , Lee Hyun‐Kyung , Kim Tae‐Bum , Cho You Sook , Moon Hee‐Bom , Lee Sang‐Do , Oh Yeon‐Mok 
Published: March 2015

AbstractBackground and objectiveIt remains difficult to differentiate between chronic obstructive pulmonary disease (COPD) and asthma in clinical practice, especially in a primary care setting. The purpose of this study was to develop a new scoring system for differentiating between COPD and asthma, and to evaluate its effectiveness.MethodsFirst, to identify important variables differentiating COPD from asthma, the data of 197 patients with COPD and 138 patients with asthma were assessed retrospectively. Secondly, a scoring system that was based on these variables was then developed, and its performance was internally validated using a bootstrapping‐based method. Thirdly, the scoring system was externally validated using prospectively collected data from patients with COPD (n = 104) or asthma (n = 96).ResultsThe final scoring system was composed of the four variables: age of onset of breathlessness (<40 years, 0 points; 40–60 years, 2 points; >60 years, 4 points), continuous breathlessness (no, 0 points; yes, 1 point), diurnal variation of breathlessness (yes, 0 points; no, 1 point) and emphysematous change in chest X‐ray (no, 0 points; yes, 1 point). The patients were classified by their total score into three categories: 0–2 points, probable asthma; 3–4 points, difficult‐to‐differentiate; 5–7 points, probable COPD. The new scoring system performed well in the external validation dataset (area under the curve, 0.86; 95% confidence interval: 0.813–0.911; P < 0.001).ConclusionsThe new scoring system that was developed in this study may be a useful tool for differentiating between COPD and asthma in primary care.
Asbestos in Asia
Authors: Leong Su Lyn , Zainudin Rizka , Kazan‐Allen Laurie , Robinson Bruce W. 
Published: March 2015

AbstractAsbestos is a global killer. Despite lessons learned in the developed world on the use of asbestos and its hazardous pulmonary consequences, its use continues to increase in Asia. Although some countries such as Japan, Korea and Singapore have curtailed the use of this mineral, there are numerous countries in Asia that continue to mine, import and use this fibre, particularly China, which is one of the largest consumers in the world. Numerous factors ranging from political and economic to the lack of understanding of asbestos and the management of asbestos‐related lung disease are keys to this observed trend. Awareness of these factors combined with early intervention may prevent the predicted Asian ‘tsunami’ of asbestos diseases.
Diagnostic evaluation for interventional bronchoscopists and radiologists in lung cancer practice
Authors: Lau W.F. Eddie , Ware Rob , Herth Felix J.F. 
Published: March 2015

AbstractThe global epidemic of lung cancer shows no signs of abating. It is generally accepted that accurate and cost‐efficient diagnostic evaluation is the first important step to achieve the best outcomes of treatment. This is true in the context of disease confirmation, treatment planning, treatment monitoring, detection of and management of treatment failure or prognostication.Fortunately, major advances in the diagnostic evaluation of lung cancer have been made in the past three decades allowing more patients to get the appropriate treatment at the right time. This paper outlines how computed tomography, positron emission tomography/computed tomography and endobronchial ultrasound contribute to lung cancer management and discuss their strengths and weaknesses and their complimentary roles at different stages of lung cancer management.Due to financial constraint and reimbursement restrictions, not all clinically important advances in the diagnostic evaluation of lung cancer have been readily accepted into routine clinical care. This enforces the need to maintain ongoing dialogue between cancer clinicians, imaging specialists and health‐care economists.
The Italian Taylor and His Boy or what Robert Armin did to Straparola
Authors: Equestri Alice 
Published: March 2015

AbstractRobert Armin is well known as the last of Shakespeare's great stage clowns, the actor who inspired the creation of characters like Touchstone, Feste and Lavatch in Shakespeare's plays. He is less known as a pamphleteer, poet and playwright, despite the fact that he seems to have been quite productive in his time. This paper analyses in particular one of his most neglected works, entitled The Italian Taylor and His Boy (1609) in relation to its source, a novella of the collection ‘Le Piacevoli Notti’ [The Pleasant Nights'] (two volumes, 1550‐1553) by the Italian author Giovan Francesco Straparola. First, I give reasons for Armin's choice, arguing that the story of Maestro Lattanzio and Dionigi might have attracted the actor's attention for its points in common with his own life. Then, I show how Armin does not produce a mere ‘translation’ of Straparola, as has sometimes been implied, but he improves the source in many ways: changing the finale and adding to the text a captivating dramatic quality, refined imagery, learned allusions and references to his own background. Finally, I consider the literary and intellectual context that influenced the writing of the poem.
Depositional and Diagenetic Controls on Pore Structure of Tight Gas Sandstone Reservoirs: Evidence from Lower Cretaceous Bashijiqike Formation in Kelasu Thrust Belts, Kuqa Depression in Tarim Basin of West China
Authors: Lai Jin , Wang Guiwen , Chai Yu , Ran Ye , Zhang Xiaotao 
Published: March 2015

AbstractDeeply buried Lower Cretaceous Bashijiqike sandstones are important gas exploration targets in the Kelasu thrust belt, Kuqa Depression of Tarim Basin in China. The sandstones are characterized by low porosity, low permeability and strong microscopic heterogeneity due to diagenesis during their geologic history. Mineralogical, petrographic, and geochemical analyses combined with high‐pressure mercury injection analysis have been used to investigate the diagenesis, diagenetic minerals, and their impact on reservoir quality. This article addresses the controls exerted by depositional parameters and diagenetic modifications on pore‐network characteristics (porosity, pore types, sizes, shapes, and distribution), with the aim to unravel the formation mechanisms of this complex pore structures, and to improve the characterization and classification evaluation for the Bashijiqike sandstone reservoirs. The Bashijiqike sandstones are dominated by lithic arkoses and feldspathic litharenite. The pore system consists of intergranular macropores, intergranular micropores, and intragranular pores. Framework grains are generally heavily compacted. Authigenic quartz, authigenic feldspar, clay minerals and carbonates are the major pore‐filling constituents. The pore structure is characterized by small pore radius and poor interconnectivity. Entry pressure reflects the microscopic pore network and macroscopic reservoir property characteristics. Pore structure characteristics are linked to the depositional parameters, type and degree of diagenesis. Clays do not control reservoir pore networks alone, and pores and pore throats are wider in coarser grained sandstones. Entry pressure decreases with the content of the rigid quartz. Compaction and cementation continue to decrease the pore‐throat size, while dissolution enlarges pores and pore‐throats radius. Considerable amounts of microporosity associated with clay minerals and altered grains contribute to the high entry pressure. Comprehensive Coefficient of Diagenesis (CCD), which considers the integrative effect of diagenesis, shows strong statistical correlations with entry pressure. CCD is an integrative modulus of diagenesis and physical property, and generally the higher the values are, the better the pore structure. It is suitable for quantitatively characterizing pore structure in tight gas sandstones. The results of this work can help assess pore‐network characteristics like the Bashijiqike sandstones which had experienced strong diagenetic modifications during their geological history.
Ar–Ar Ages of Hydrothermal Muscovite and Igneous Biotite at the Guposhan–Huashan District, Northeast Guangxi, South China: Implications for Mesozoic W–Sn Mineralization
Authors: Li Xiaofeng , Xiao Rong , Feng Zuohai , Chunxia Wei , Tang Yanwen , Bai Yanping , Zhang Mingji 
Published: March 2015

AbstractThe Guposhan–Huashan district is an important W–Sn–Sb–Zn–(Cu) metallogenic area in South China. It is located in the middle‐west segment of the Nanling Range. Granitoids in the Guposhan–Huashan district possess certain properties of A‐type or I‐type granites. The W–Sn–Sb–Zn mineralization in the district is closely associated with magma emplacement. Two igneous biotite and seven hydrothermal muscovite samples from skarn, veins and greisenization ores were analyzed by Ar–Ar methods. Two igneous biotite samples from fine‐grained quartz monzodiorite and fine‐grained biotite granite show plateau ages of 168.7 ± 1.9 Ma and 165.0 ± 1.1 Ma, respectively. Seven hydrothermal muscovite samples from ores yield plateau ages as two groups: 165 Ma to 160 Ma and 104 Ma to 100 Ma. These data suggest that the emplacement of fine‐grained granitoids in this district is coeval with the main phase magma emplacement, different from previous studies. The W–Sn–Sb–Zn mineralization took place in two stages, i.e. the Middle–Late Jurassic and early Cretaceous. W–Sn mineralization in the Guposhan–Huashan district is closely related to the magmatism, which was strongly influenced by underplating of asthenospheric mantle along trans‐lithospheric deep faults and related fractures.