bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing T‐cell receptor clonality by next‐generation sequencing in atypical cutaneous lymphoid infiltrates and cutaneous T‐cell lymphoma: A scoping review
Authors: Shinohara Michi M. , Rieger Kerri E. , Sundram Uma , Fung Maxwell A. , Hristov Alexandra C. 
Published: July 2024

AbstractThe diagnosis of cutaneous T‐cell lymphoma (CTCL) remains challenging. Demonstration of a clonal T‐cell population using T‐cell receptor (TCR) gene rearrangement studies by next‐generation sequencing (NGS) has been explored in several studies. This review summarizes the current literature on NGS‐based sequencing methods for the assessment of TCR clonality in the evaluation of atypical cutaneous lymphoid infiltrates and CTCL on behalf of the American Society of Dermatopathology Appropriate Use Criteria Committee (lymphoproliferative subgroup). PubMed was searched for relevant articles, including CTCL and NGS, for clonality from 1967 to 2022. Thirteen studies were included in the analysis. The skin was the most commonly assayed compartment with TCR NGS. Sensitivity for TCR NGS in the skin ranged between 69% and 100%, compared to 44%–72% for polymerase chain reaction (PCR)‐capillary electrophoresis. Specificity for TCR NGS in the skin ranged from 86% to 100%, compared to 77%–88% for PCR capillary electrophoresis. TCR NGS was also reported to have potential prognostic value in CTCL and can also be used to detect relapse and/or minimal residual disease after treatment.
Characteristics of pipestems from acid sulfate soils of Finland and Australia
Authors: Yli‐Halla Markku , Sullivan Leigh 
Published: July 2024

AbstractThis study describes iron (Fe) pipestems formed around and within root channels during the development of a homogeneous unripe sulfidic sediment into a ripe soil where redox‐ or pH‐active elements segregate. Pipestems and adjacent soil material samples were characterised by chemical and mineralogical analyses and scanning electron microscopy (SEM) associated with energy dispersive spectroscopy (EDS). Pipestems occurred at 60–190 cm and at 30–130 cm in a young Finnish soil and a more mature Australian soil, respectively, while sulfidic materials were found below 170–180 cm. The pipestems consisted of mineral grains cemented together by Fe precipitate. There was an up to 24‐fold enrichment of Fe and an up to 13‐fold enrichment of sulfur (S) in the Finnish pipestems compared to the adjacent soil material, whereas the corresponding enrichment in the Australian soil was up to 27‐fold for Fe and up to 8‐fold for S. In the Australian pipestem matrices, the Fe concentration was as high as 40% compared to 14% in the Finnish ones. It was estimated that about 70 ton ha−1 S had been mobilised from the sulfidic material in the Finnish soil at the depth of 50–150 cm. Part of S has leached out but a substantial amount remained in the soil constituting the stock of retained acidity. Almost all pipestems contained a new solid phase precipitated within the former cortex cells of the plant roots. In the Finnish samples, this precipitate consisted of jarosite and schwertmannite. After oxidative exhaustion of sulfidic material in the surrounding soil, these metastable minerals are gradually hydrolysed, associated with leaching of S. In the mature Australian soil, most of these minerals had already been transformed to goethite. Pipestems formed after roots in unripe soil are sites for synthesis and hydrolysis of minerals and serve as routes for atmospheric oxygen into the reduced subsoil and for soluble reaction products to exit the soil. Pipestems have an important role in the ripening of the soil profile.
Using social integration mechanisms to boost absorptive capacity: Walking a tightrope
Authors: Dávila Guillermo Antonio , Andreeva Tatiana , Sætre Alf Steiner 
Published: July 2024

AbstractWith the increasing recognition of the value of external knowledge, organisations are interested in understanding how to boost their absorptive capacity. Social integration mechanisms have been theorised as a key predictor of absorptive capacity, both as a necessary condition for the development of its dimensions (knowledge acquisition, assimilation, transformation and application) and as a contingency factor that influences the relationships between these dimensions. However, the empirical evidence that explores these ideas is limited. To address this, we explore the survey data from 145 Brazilian firms and find that social integration mechanisms play a controversial role in absorptive capacity. Without a certain level of social integration mechanism usage, high levels of the absorptive capacity dimensions are not possible. However, social integration mechanisms also dampen the positive effects of knowledge acquisition on knowledge assimilation and transformation. Therefore, the highest level of usage of social integration mechanisms is not always beneficial for organisations.
Thermal response of freshwater ciliates: Can they survive at elevated lake temperatures?
Authors: Weisse Thomas 
Published: July 2024

Abstract

Ciliates are a well‐defined, species‐rich, versatile group of heterotrophic and mixotrophic protists. Their response to increased temperature during global warming is critical for the structure and functioning of freshwater food webs.

I conducted a meta‐analysis of the literature from field studies and experimental evidence to assess the parameters characterising the thermal response of freshwater ciliates. The shape of the thermal performance curve predicts the ciliates' survival at supraoptimal temperatures (i.e., the width of the thermal safety margin).

The ciliates' typical thermal safety margin is c. 5°C. More than two‐thirds of the freshwater ciliates dwelling permanently or occasionally in the pelagial cannot survive at temperatures exceeding 30°C. Likewise, cold‐stenothermic species, which represent a significant fraction of euplanktonic ciliates, cannot survive by evolutionary adaptation to rapidly warming environments.

The statistical analysis revealed that the ciliates' thermal performance is affected by their planktonic lifestyle (euplanktonic vs. tychoplanktonic), ability to form cysts and nutritional ecology. Bactivorous ciliates have the widest temperature niche, and algivorous ciliates have the narrowest temperature niche.

Phenotypic plasticity and genetic variation, favouring the selection of pre‐adapted species in a new environment, are widespread among freshwater ciliates. However, the lack of evidence for the temperature optima and imprecisely defined tolerance limits of most species hampers the present analysis. The extent of acclimation and adaptation requires further research with more ciliate species than the few chosen thus far.

Recent eco‐evolutionary experimental work and modelling approaches have demonstrated that the ciliates' thermal responses follow general trends predicted by the metabolic theory of ecology and mechanistic functions inherent in enzyme kinetics. The present analysis identified current knowledge gaps and avenues for future research that may serve as a model study for other biota. Thermal adaptation may conflict with adaptation to other stressors (predators, food availability, pH), making general predictions on the future role of freshwater ciliates in a warmer environment difficult, if not impossible, at present.
Effects of tourism on socio‐economic well‐being and its inter‐regional convergence: Evidence from China's 291 cities
Authors: Zhu Fubiao , Cao Xiaona , Zhuang Delin , Jin Shengwu , Yang Xueting 
Published: July 2024

AbstractBig socio‐economic well‐being gap is common across countries and regions. This study examines the impact of tourism on socio‐economic well‐being and its convergence from a comprehensive and inter‐regional convergence perspective. Using panel data of 291 cities during the period 2005–2019, we provide the comprehensive evaluation of socio‐economic well‐being at the city scale in China. Considering the dynamic characteristics of socio‐economic well‐being, we therefore estimate the impact using the system generalized method of moments. The result indicates that tourism significantly enhances local socio‐economic well‐being and is found to be robust. We also find the dominance of domestic tourism, the positive moderator effects of general budget expenditure, GDP per capita and urbanization, and a greater driving force in cities with higher socio‐economic well‐being. Since both β‐ and σ‐convergence hold, we confirm the positive effect of tourism on the convergence of inter‐regional socio‐economic well‐being. We emphasize policies support for tourism development in underdeveloped regions through fiscal expenditure, financial transfer payments, intellectual support, urbanization, and infrastructure construction. We suggest incorporating tourism into frameworks such as rural revitalization and regional coordinated development. We also recommend accelerating the expansion of tourism in underdeveloped regions and enhancing the quality of tourism in developed regions as spatial strategies, while emphasizing inter‐regional tourism coordination and cooperation.
Experience of living with psoriasis in Brazil: a Global Psoriasis Atlas online survey
Authors: Silva Jaquelini Barboza da , Wright Alison K. , Carvalho André V. E. , Griffiths Christopher E. M. , Ashcroft Darren M. 
Published: July 2024

AbstractBackgroundPsoriasis significantly burdens patients' lives, but there is limited data on this in Brazil.MethodsBetween May 2022 and January 2023, we conducted a cross‐sectional online survey of 563 Brazilian residents aged ≥18 years who had been diagnosed with psoriasis. Spearman's correlation (r) was used to test the correlation between self‐assessed disease severity (Simplified Psoriasis Index [saSPI] extent score; range 0 [clear/minor] to 40 [widespread/severe]) and health‐related quality of life (QoL, score of 1 means perfect health) and capability (ICECAP‐A: score of 1 means full capability) measures. Multivariable linear regression was used to identify predictors of QoL and capability. A thematic analysis examined the free‐text responses and identified common themes.ResultsThe mean age of participants was 42.1 ± 12.4 years, and over half had at least one other long‐term condition. The mean QoL score was 0.59 ± 0.25, and the mean capability score was 0.71 ± 0.21. At the time of survey completion, over 80% of respondents reported some level of pain and/or discomfort, and 86% reported feeling anxious and/or depressed. The mean self‐assessed saSPI was 7.8 ± 8.6, which negatively correlated with health‐related QoL (r = −0.49, P < 0.05) and capability (r = −0.44, P < 0.05). Significant predictors of poorer QoL and reduced capability included high saSPI, number of psoriasis flares and comorbidities, female gender, Black ethnicity, and employment status (unemployed, long‐term sick). Frequently reported areas that impacted patients were social stigma/prejudice, powerlessness, lack of education and public awareness, and difficulty obtaining appropriate care/treatment.ConclusionsWe found that the clinical manifestations, severity, and associated comorbidities of psoriasis negatively impacted health‐related QoL and capability, along with feelings of stigmatization and barriers to specialist treatment. This highlights the need for better access to care and awareness of the disease to improve the lives of people living with psoriasis in Brazil.
Enhancement of Waterlogging Tolerance and Improvement of Grain Quality in Waxy Maize With Exogenous EDAH: A Mixture of Ethephon and Diethyl Aminoethyl Hexanoate
Authors: Huang Chao , Liu Xuchen , Ma Shoutian , Qin Anzhen , Zhang Yingying , Xie Yuxiang , Gao Yang , Liu Zhandong 
Published: July 2024

ABSTRACTGlobal warming has led to more frequent extreme weather events, such as heavy summer rains, in the Huang‐Huai‐Hai region. These events significantly impede the growth and development of waxy maize in the area and disrupt the stable progression of the industry. However, there is a lack of effective agricultural measures to mitigate the impact of waterlogging, and the underlying regulation mechanisms remain unclear. To fill this knowledge gap, we conducted a two‐year experiment to assess whether exogenous EDAH (a mixture of ethephon and diethyl aminoethyl hexanoate (DA‐6), ethephon: DA‐6 = 27%: 3%) application during the waxy maize V6 stage, combined with 10 days of waterlogging treatment at the V6, VT and R2 growth stages. The results indicate that exogenous EDAH mitigates the adverse effects of waterlogging stress to a certain extent. It is noteworthy that exogenous EDAH increases the leaf area index and photosynthetic parameters of waxy maize, enhances the activity of catalase in ear leaves at the R3 stage, inhibits the accumulation of malondialdehyde and delays premature aging of plants. Furthermore, exogenous EDAH delays premature ripening of grains caused by waterlogging, increases the moisture content of fresh waxy maize grains during the fresh edible period, but does not effectively mitigate the yield losses caused by waterlogging. However, exogenous EDAH effectively improves grain quality under waterlogging stress, increasing the soluble sugar content and total protein content while reducing starch content, ultimately enhancing the edibility of fresh ears. Through TOPSIS comprehensive evaluation, it can be inferred that exogenous EDAH effectively mitigates the overall impact of waterlogging on waxy maize at both the V6 and VT stages. This research sheds light on potential strategies to mitigate the adverse effects of waterlogging on agricultural productivity and grain quality.
Unveiling Superabsorbent Hydrogels Efficacy Through Modified Agronomic Practices in Soybean–Wheat System Under Semi‐Arid Regions of South Asia
Authors: Adireddy Rajanna G. , Manna Suman , Patanjali Neeraj , Singh Anupama , Dass Anchal , Mahanta Dibakar , Singh Vinod Kumar 
Published: July 2024

ABSTRACTThe sustainability of global agriculture at higher productivity level is a concern owing to climate change, serious environmental footprints, dipping factor productivity and shrinking availability of natural resources, especially. The situation is worsening in the ‘Food Bowl of India’—Indo‐Gangetic plains (IGP) by several amalgamated factors, such as declining groundwater, unpredictable precipitation owing to climate change and cultivation of heavy water duty crops. To neutralise these issues, a field experiment was executed for the period 2019–2021 to assess the efficacy of indigenous hydrogels (P‐hydrogel and Superabsorbent polymer hydrogel‐1118) and their application methods viz., seed treatment, slurry application and soil application on crop yield and water productivity, soil moisture dynamics and profitability in a soybean–wheat cropping system under irrigation and rainfed conditions. In both study years (2019–2020 and 2020–2021), due to higher seed germination percentage, irrigation application together with seed treatment and slurry application of superabsorbent polymer hydrogel‐1118 improved system productivity by 8.1%–26.7% and system water productivity by 17.6%–33.8% over control. Wheat grain yield was enhanced by 8.0% (2019–2020) to 32.2% (2020–2021) due to superabsorbent polymer hydrogel‐1118 hydrogel with 10 cm lesser use of irrigation water compared with control (no‐hydrogel). Soil moisture content in 0–15 cm soil layer was also found higher by 1.8%–2.4% in superabsorbent polymer hydrogel‐1118 and P‐hydrogel slurry‐applied plots. Therefore, higher gross profitability (31.8%), net profitability (89.8%) and B:C (26.9%) in wheat could be attributed to increased crop yields when seeds were treated with superabsorbent polymer hydrogel‐1118. Therefore, the utilisation of modified hydrogel application, in the form of seed treatment (seed coating) and slurry application has demonstrated improvement in seed germination, crop yield and water productivity and made soybean–wheat cultivation more economical. This approach presents a feasible solution to achieving a viable production system of soybean and wheat crops by reducing irrigation amounts in the IGP of India, as well as other comparable ecological places worldwide.
Small Stomates and Xylem Vessels Associated With Freeze Tolerance in Winter Barley
Authors: Liang Xi , Hu Gongshe , McDougall Lisa , Werth Jason , Yang Rui , Yang Jingya , Evans Chris , Satterfield Kathy 
Published: July 2024

ABSTRACTFreeze tolerance is a complex agronomic trait that is difficult to evaluate in the field because of year‐to‐year variation in weather. Discovering plant characteristics closely related to freeze tolerance would enable more effective selection for this important trait. To explore possible physiological mechanisms and search for useful characteristics related to freeze tolerance in winter barley, we conducted field and growth chamber experiments with seven freeze‐tolerant and seven freeze‐susceptible genotypes that exhibited contrasting winter survival in preliminary field screenings. In a 2‐year field experiment, malondialdehyde, proline and water‐soluble carbohydrate concentrations were measured during cold acclimation and deacclimation to investigate differences in osmoregulation and membrane stability between freeze‐tolerant and freeze‐sensitive genotypes. All parameters varied by sampling year, and significant differences between freeze tolerance groups were found mainly during cold deacclimation in the spring. In growth chamber experiments, the size of xylem vessels and stomates was measured with and without cold acclimation. Freeze‐tolerant genotypes had smaller xylem vessels and stomates than freeze‐sensitive genotypes with and without cold acclimation, and small stomatal length was associated with a small xylem vessel area. Thus, it may be possible to improve freeze tolerance in winter barley by selecting smaller xylem and stomate cells. This study also validated germplasms of winter barley with differential freeze tolerance for future projects on breeding for improving winter hardiness and on plant physiology and genetics in response to freezing stress.
Sleep‐specific repetitive negative thinking processes and prenatal insomnia symptoms: A naturalistic follow‐up study from mid‐ to late‐pregnancy
Authors: Wang Juan , Huang Yongqi , Wu Liuliu , Sun Yaoyao , Zhang Xuan , Cao Fenglin 
Published: July 2024

SummaryInsomnia symptoms are highly prevalent during pregnancy; therefore, identifying modifiable risk markers is important for risk prediction and early intervention. This study aimed to examine the role of sleep‐specific rumination and sleep‐specific worry in prenatal insomnia symptoms. A total of 859 married pregnant women without history of psychiatric illnesses (mean [standard deviation] age, 30.15 [3.86] years; 593 [69.0%] with a bachelor's degree or above) were enrolled from the obstetrical outpatient departments of two tertiary comprehensive hospitals in Shandong, China, who completed assessments of sleep‐specific rumination, sleep‐specific worry, and insomnia symptoms at baseline (mid‐pregnancy) and follow‐up (late‐pregnancy). Measures included Daytime Insomnia Symptom Response Scale, Anxiety and Preoccupation about Sleep Questionnaire, and Insomnia Severity Index. Our results showed that after controlling for covariates, both sleep‐specific rumination and sleep‐specific worry showed significant concurrent and prospective associations with insomnia symptoms, and the increases in scores of sleep‐specific rumination and sleep‐specific worry over time were significantly associated with the increased likelihood of insomnia symptoms at follow‐up. Moreover, the increases in sleep‐specific rumination and sleep‐specific worry over time were significantly associated with the increased likelihood of reporting newly developed insomnia symptoms rather than persistent normal sleep. However, the changes in sleep‐specific rumination and sleep‐specific worry were not significantly associated with the likelihood of reporting persistent or remitted insomnia symptoms rather than persistent normal sleep. In conclusion, sleep‐specific rumination and sleep‐specific worry were significantly associated with concurrent or subsequent insomnia symptoms; thus, they may be promising cognitive risk markers and intervention targets.
Detection and severity assessment of obstructive sleep apnea according to deep learning of single‐lead electrocardiogram signals
Authors: Zhang Yitong , Shi Yewen , Su Yonglong , Cao Zine , Li Chengjian , Xie Yushan , Niu Xiaoxin , Yuan Yuqi , Ma Lina , Zhu Simin , Zhou Yanuo , Wang Zitong , Hei XinHong , Shi Zhenghao , Ren Xiaoyong , Liu Haiqin 
Published: July 2024

SummaryDeveloping a convenient detection method is important for diagnosing and treating obstructive sleep apnea. Considering availability and medical reliability, we established a deep‐learning model that uses single‐lead electrocardiogram signals for obstructive sleep apnea detection and severity assessment. The detection model consisted of signal preprocessing, feature extraction, time–frequency domain information fusion, and classification segments. A total of 375 patients who underwent polysomnography were included. The single‐lead electrocardiogram signals obtained by polysomnography were used to train, validate and test the model. Moreover, the proposed model performance on a public dataset was compared with the findings of previous studies. In the test set, the accuracy of per‐segment and per‐recording detection were 82.55% and 85.33%, respectively. The accuracy values for mild, moderate and severe obstructive sleep apnea were 69.33%, 74.67% and 85.33%, respectively. In the public dataset, the accuracy of per‐segment detection was 91.66%. A Bland–Altman plot revealed the consistency of true apnea–hypopnea index and predicted apnea–hypopnea index. We confirmed the feasibility of single‐lead electrocardiogram signals and deep‐learning model for obstructive sleep apnea detection and severity evaluation in both hospital and public datasets. The detection performance is high for patients with obstructive sleep apnea, especially those with severe obstructive sleep apnea.
Improved brachial skin hydration and appearance with hyperdiluted calcium hydroxylapatite
Authors: Palo Juliana Schinzari , de Lima Faria Gladstone Eustáquio , McCarthy Alec D. , Boggio Ricardo Frota 
Published: July 2024

AbstractIntroductionThe search for minimally invasive treatments for areas not covered by clothing, such as the arms, has increased, particularly to combat flaccidity resulting from factors such as aging and weight loss. This study evaluated the efficacy of calcium hydroxyapatite (CaHA), an injectable biostimulator, in improving flaccidity and hydration of the skin of the arms.Materials and MethodsSix women between 40 and 50 years old with visible signs of brachial flaccidity were selected. Calcium hydroxyapatite was injected into the arms in a 1:4 dilution (1.5 mL per side), with subjective evaluation based on the GAIS score and objective hydration analysis using corneometry.ResultsAfter a single application of CaHA, there was a significant increase in skin hydration (12.2%), objectively assessed by corneometry. Patient and physician satisfaction was high, evidenced by visible improvements in photographs and by the GAIS score. No significant adverse events were reported, demonstrating the safety of the procedure.DiscussionOur clinical observations confirm the ability of CaHA to visibly improve arm flaccidity. In addition, hydration measures support previous histological studies demonstrating increases in dermal proteoglycans. Compared to other studies, the increase in skin hydration with CaHA was similar to those obtained with hyaluronic acid, suggesting comparable results with a more comfortable and less invasive technique.ConclusionThis study demonstrates the efficacy of CaHA in improving hydration of brachial skin after a single treatment. Despite the limitations of the sample size, the research contributes to the medical literature, highlighting the utility of the 3 mL CaHA presentation for brachial treatment with objective results in skin hydration.