bluuebunny/crossref_metadata_2025_split huggingface dataset:
Progressive Systemic Sclerosis Sine Scleroderma which Developed after Exposure to Epoxy Resin Polymerization
Authors: Inachi Shin , Mizutani Hitoshi , Ando Yoko , Shimizu Masayuki 
Published: April 2015

AbstractProgressive systemic sclerosis (PSS) sine scleroderma is well known as a special form of scleroderma. Because of its rarity, its pathogenesis has not yet been elucidated. We experienced a 33‐year‐old man who developed PSS sine scleroderma while working with epoxy resin polymerization. He had short white frenulum linguae, diffuse hyperpigmentation and facial telangiectasia, positive antinuclear antibody, and pulmonary dysfunction, but not acrosclerosis or sclerodactylia. Modest dermal collagen proliferation in the forearm skin confirmed PSS sine scleroderma. Epoxy resin polymerizer appears to be a potent causative agent for PSS sine scleroderma as well as for generalized morphea‐like PSS.
Immunohistochemical Detection of p53 Tumor Suppressor Protein in Porokeratosis
Authors: Urano Yoshio , Sasaki Shiro , Ninomiya Yoshiro , Oura Hajimu , Arase Seiji 
Published: April 2015

AbstractWe examined 9 Japanese cases of porokeratosis (4 of the plaque type, 2 of disseminated superficial actinic porokeratosis, 2 of disseminated superficial porokeratosis, and one of giant porokeratosis) for the expression of p53 tumor suppressor protein immunohistochemically, using two anti‐p53 antibodies, CM1 and DO1. The same results were obtained with both antibodies. The epidermis central to the cornoid lamellae was positive in 8 of 9 specimens. On the other hand, the peripheral epidermis was positive in 2 of the 9 cases. The epidermis beneath the cornoid lamellae was positive in 3 of the 9 cases. The frequency of p53 positivity was significantly higher in the epidermis central to cornoid lamellae over that beneath or peripheral to them (Fisher's exact probability test, p<0.05). The majority of squamous cell carcinoma cells arising on giant porokeratosis stained with CM1 and DO1. These data may suggest that the abnormal p53 expression has some relevance to the skin carcinogenesis of porokeratosis.
Paraneoplastic Pemphigus: Report of a Case
Authors: Izaki Seiichi , Yoshizawa Yusuke , Hashimoto Takashi , Korman Neil J. , Kitamura Keijiro , Hamamatsu Yasushi , Ohashi Norio , Ogasa Shinji 
Published: April 2015

AbstractA 56‐year‐old male with chronic lymphocytic leukemia developed extensive erosive mucocutaneous lesions with histologic acantholysis. Immunopathologic studies showed IgG deposition at the intercellular space, C3 deposition at both the intercellular space and the dermo‐epidermal junction, and reactivity of the serum to rat urinary bladder epithelium. Autoantibodies in the serum to human epidermal proteins of 210 kD and 190 kD were shown by Western blotting and to proteins of 250 kD, 210 kD, and 190 kD by immunoprecipitation. All these data suggest the diagnosis of paraneoplastic pemphigus. Repeated plasmapheresis resulted in re‐epithelialization of the mucocutaneous lesions and reduction in antibody titer from 1:1280 to 1:20. Although this mucocutaneous disease was established as a new autoimmune bullous disease by Anhalt et al. (1990), cases have rarely been reported from Japan. The present patient demonstrates the major characteristics of paraneoplastic pemphigus.
Extramammary Paget's Disease with Distant Skin Metastasis
Authors: Kato Naoko , Matsue Keiko , Sotodate Akihiro , Tomita Yuki 
Published: April 2015

AbstractWe report a 68‐year‐old Japanese man with invasive extramammary Paget's disease (EPD) which started in the left inguinal area and enlarged to include the scrotal skin, penis, and pubic area, resulting in lymph edema of the entire left leg. Histopathological examination of one nodule revealed an intraepidermal and intradermal arrangement of solid tumor cells with characteristic pale cytoplasm. The tumor was found to have disseminated to regional and systemic lymph nodes, lungs, bones, and the left adrenal gland. In addition, the patient had a metastatic cutaneous nodule on the scalp. Histology of the skin metastasis showed that the proliferation of Paget cells was confined to the dermis. This type of metastatic spread of EPD is very rare; only two other apparent cases in Japan have been reported.
A Case of Eosinophilic Pustular Folliculitis (Ofuji's Disease) Induced by Patch and Challenge Tests with Indeloxazine Hydrochloride
Authors: Kimura Kyoko , Ezoe Kazuhiko , Yokozeki Hiroo , Katayama Ichiro , Nishioka Kiyoshi 
Published: April 2015

AbstractA 73‐year‐old male developed disseminated erythema over his entire body after exposure to indeloxazine hydrochloride, a cerebral activator. Patch testing with indeloxazine hydrochloride showed a positive reaction, and plaques, vesicles and pustules developed on the face after the patch test. These had the pathologic feature of eosinophilic pustular folliculitis (EPF, Ofuji's disease). A challenge test also provoked eruptions on the face, trunk, arms and legs, which were compatible with EPF. Moreover, both the patch and challenge tests with indeloxazine hydrochloride induced eosinophilia. This is the first report of drug allergy‐induced EPF, where drug sensitivity induced an abnormal eosinophilic response mimicking EPF.
Palmar Erythema Ab Igne without Detectable Type IV Collagen at the Basement Membrane Zone
Authors: Yasuda Kayo , Wada Emi , Kitagawa Nobuko , Ikeda Mitsunori , Kodama Hajime 
Published: April 2015

AbstractA 42‐year‐old baker had hyperkeratotic lesions on reticular erythema of his palms and volar digits. Attachment between the epidermis and the dermis was loose at the hyperkeratotic sites, but no blisters had formed. After he stopped work for 2 months, the skin lesions disappeared, leaving a slight scar. Immunofluorescence studies showed a normal distribution of type VII collagen and laminin, but there was almost no fluorescence for type IV collagen in the basement membrane zone. Disappearance of cytoplasmic organelles and aggregated tonofibrils was evident under electron microscopy in the basal cells which appeared shrunken under light microscopy. The structures of lamina lucida, basal lamina and anchoring fibrils were disarranged. The loose dermo‐epidermal attachment is probably due in part to this disorganized basement membrane structure lacking type IV collagen, which may have been digested by heat‐activated matrix metalloproteinases. In addition, his work‐related chronic heat exposure might have caused hyperproliferation of keratinocytes.
Three Cases of Pasteurella multocida Skin Infection from Pet Cats
Authors: Matsui Tamano , Kayashima Ken‐ichi , Kito Masato , Ono Tomomichi 
Published: April 2015

AbstractWe encountered three cases of Pasteurella multocida skin infection from pet cats. P. multocida wound infections are characterized by acute onset of erythema, pain, and swelling. This infection has rarely been reported in dermatology journals from Japan.
Angina Bullosa Hemorrhagica
Authors: de las Heras M. Elena , Moreno R. , Núñez María , Gómez M. Isabel , Ledo Antonio 
Published: April 2015

AbstractAngina bullosa hemorrhagica is characterized by acute blood blisters, mainly on the soft palate. Elderly patients are usually affected and lesions heal spontaneously without scarring. The pathogenesis is unknown, although it may be a multifactorial phenomenon. Trauma seems to be the major provoking factor and long term use of steroid inhalers has also been implicated in the disease. No underlying hematologic or immunopathogenic disorder has been found. Treatment is symptomatic.We present a 67‐year‐old patient with recurrent oral blood blisters which were diagnosed as angina bullosa hemorrhagica. Trauma by dental injections and use of steroid inhalers were identified as etiologic factors in this case. Erosions healed within a week.Although this is a benign condition, it may result in acute airway obstruction. Recognition is, therefore, of great importance for dermatologists.
Relationship between Levels of Soluble Interleukin‐2 Receptors and the Types and Activity of Vitiligo
Authors: Honda Yoshihide , Okubo Yukari , Koga Michiyuki 
Published: April 2015

AbstractLevels of serum‐soluble interleukin‐2 receptors (serum sIL‐2R) are thought to indicate the activation of immunocompetent cells, mainly lymphocytes. Elevated levels of serum sIL‐2R have been observed in various infectious and autoimmune diseases and also after organ transplantation. It has been hypothesized that autoimmune mechanisms are involved in the pathogenesis of vitiligo. Therefore, we studied serum sIL‐2R levels in relation to disease types and activity of vitiligo. We used sera separated from venous blood samples from 12 patients with dermatomally distributed type B vitiligo, 17 patients with non‐dermatomally distributed type A vitiligo during the active stage, 9 patients with type A vitiligo during the inactive stage, and 12 normal control subjects.Serum sIL‐2R levels were similar in type B vitiligo patients and the controls but were significantly elevated in patients with active type A vitiligo compared with controls and inactive type A vitiligo patients. It is suggested that the immune system is activated in patients with type A vitiligo during the active stage and that autoimmune mechanisms may play a role only in type A vitiligo.
A Verrucous Lesion on Skin Grafted after Necrotizing Fasciitis in a Diabetic Patient Successfully Treated with Combined Topical 5‐FU and Tacalcitol
Authors: Sakai Hiroyuki , Fukami Yoichi , Ibe Masaki , Tamura Toshiya , Hashimoto Yoshio , Iizuka Hajime 
Published: April 2015

AbstractMany complications of diabetes mellitus involve the feet. These include infections, neuropathy, vasculopathy, and poor wound healing. Neuropathy causes chronic pressure or friction on an area of sensory loss and occasionally causes verrucous skin lesions. We describe a diabetic patient, complicated by necrotizing fasciitis, who developed a verrucous skin lesion on a skin graft site. The verrucous skin lesion was treated successfully with combined topical 5‐fluorouracil and vitamin D3 application.
Rudimentary Meningocele of the Scalp
Authors: Mihara Yuko , Miyamoto Toru , Hagari Yoshitaka , Mihara Motoyuki 
Published: April 2015

AbstractA rudimentary meningocele, a variant of primary cutaneous meningioma, was seen on the scalp of a 9‐month‐old Japanese boy. Clinically, the lesion on the left parietal area was round, about 1.6 cm in diameter, alopecic, and slightly elevated. Histologically, the lesion, located from the dermis to the subcutis, consisted of scattered foci of meningothelial cells, an anastomosing network of empty spaces with psammoma bodies and collagen bodies, and small vessels. Immunohistochemically, the meningothelial cells were positive for vimentin and desmin. Ultrastructurally, they had elongated cytoplasmic processes, intermediate filaments in the cytoplasm, and desmosomal junctions.
Dermatomyositis Associated with Primary Intramuscular B Cell Lymphoma
Authors: Anzai Saburo , Katagiri Kazumoto , Sato Toshihiro , Takayasu Susumu 
Published: April 2015

AbstractA rare case of dermatomyositis associated with primary intramuscular malignant lymphoma is described. A 40‐year‐old Japanese woman noticed swelling of the right thigh during the treatment of dermatomyositis with prednisolone, azathioprine and cyclophosphamide. A biopsy specimen taken from the right quadriceps muscle revealed infiltration of lymphoma cells which were positive for CD20. We reviewed 12 cases of dermatomyositis associated with malignant lymphoma reported in Japanese literature between 1984 and 1996.
Sister Joseph's Nodule: A Case Report and Review of the Japanese Literature
Authors: Ishizawa Toshiyuki , Mitsuhashi Yoshihiko , Kondo Shigeo , Watabe Syuichi 
Published: April 2015

AbstractWe report a case of metastatic carcinoma on the umbilicus, which is known as Sister Joseph's nodule. A 65‐year‐old man with the chief complaint of a painful nodule on the umbilicus was refered to our hospital. Histopathological examination revealed moderately differentiated tubular adenocarcinoma in the dermis. Endoscopic examination found gastric cancer of Borrmann type IV. The umbilical lesion represented a metastasis from the gastric cancer. We reviewed 80 cases of metastatic carcinomas to the umbilicus that have been reported in the Japanese literature.
‘Swiss Cheese’ Lymphangiectasia in a Case of Solitary Morphea Profunda
Authors: Ahn Sung Ku , Won Jin Hyoung , Lee Seung Hun , Lee In Wook , Lee Won Soo , Choi Eung Ho 
Published: April 2015

AbstractReports of lymphangiectases that occur in lesions of morphea are rare. We describe a 24‐year‐old woman with a solitary morphea profunda associated with lymphangiectasia. Unlike previously reported cases, our case showed lymphatic dilatation resembling Swiss cheese and developed around a milium.
Congenital Ectopic Nails Reconstructed with Local Skin Flaps
Authors: Kimura Chu , Oyama Akihiko , Kouraba Sachio 
Published: April 2015

AbstractCongenital ectopic nails are quite unusual and characterized by development of nail‐like tissue on the tips of one or more fingers. We present the case of a boy with congenital ectopic nails on both little fingers. To prevent tapering of the fingertips following surgery, we used subcutaneous pedicle flaps and obtained a satisfactory cosmetic result.
Papillary Tubular Adenoma with Marked Tubular Vacuolization
Authors: Hattori Naoko , Imakado Sumihisa , Kikuchi Kanako , Murakami Toshikazu , Furue Masutaka 
Published: April 2015

AbstractWe report a case of papillary tubular adenoma, arising on the knee joint. The overall histologic structure of the tumor is consistent with that of papillary tubular adenoma with slight interluminal papillary changes, but most of the tumor cells present vacuolization outlined by carcinoembryonic antigen staining, suggesting that this adenoma may have resulted from microlumen formation. This is, to our knowledge, the first reported case of a papillary tubular adenoma with marked tubular vacuolization.
Pseudo‐Kaposi's Sarcoma Associated with Acquired Arteriovenous Fistula
Authors: Kim Tae‐Heung , Kim Kab‐Hyeong , Kang Jin‐Soo , Kim Jae‐Hyoung , Hwang Il‐Yong 
Published: April 2015

AbstractPseudo‐Kaposi's sarcoma or acroangiodermatitis usually has underlying conditions of increased venous pressure or circulatory abnormality. We experienced two cases of pseudo‐Kaposi's sarcoma in patients with acquired iatrogenic arteriovenous fistula from hemodialysis on their forearms.The patients complained of painful swollen crusted vesicles and purple or erythematous patches or plaques on their hands and fingers. Histologic findings included features of pseudo‐Kaposi's sarcoma such as proliferations of small vascular spaces with narrow vascular channels lined by spindle cells, extravasated erythrocytes, and hemosiderin deposits.Percutaneous arteriography performed in Case one excluded the possible coexistence of arteriovenous malformation. In both cases, venous pressure and skin surface temperature were increased around the lesions; these may have played important roles in the development of the lesions.Both cases improved after oral erythromycin treatment, which seemed to be safe and effective for pseudo‐Kaposi's sarcoma.
Cutaneous Horn: A Brief Review and Report of a Case
Authors: Thappa Devinder Mohan , Garg Bhagat Ram , Thadeus Joseph , Ratnakar Chaganti 
Published: April 2015

AbstractA case of extensive verrucae vulgaris with cutaneous horns in a 32‐year‐old man is reported. Accompanying terminal phalangeal bone absorptive changes in the fingers of both hands, resulting from subungual warty lesions, are highlighted. The existing literature on the subject of cutaneous horn is briefly reviewed.
Asymptomatic Primary Sjögren's Syndrome in a Patient with Penicillin Drug Eruption
Authors: Takahashi Hiroyuki 
Published: April 2015

AbstractA 20‐year‐old woman visited our clinic because of acral numbness and skin eruptions after administration of oral penicillin. Serological tests revealed an increase of immunoglobulins (G & M), positive rheumatoid factor, anti‐nuclear factor, anti‐SSA and ‐SSB antibodies. Ophthalmologic and otolaryngological studies were consistent with those of Sjögren's syndrome. However, a skin biopsy specimen failed to show any specific changes for Sjögren's syndrome and the diagnosis of penicillin drug eruption was considered to be more preferable. We briefly discussed the coexistence of a drug allergy and asymptomatic connective tissue disease.
The Inhibitory Effect of Anti‐Adhesion Molecule Antibodies on Eosinophil Infiltration in Cutaneous Late Phase Response in Balb/c Mice Sensitized with Ovalbumin (OVA)
Authors: Hakugawa Junichi , Bae Sang Jae , Tanaka Yoichi , Katayama Ichiro 
Published: April 2015

AbstractIn this study, we investigated the involvement of the adhesion molecules intercellular adhesion molecule‐1 (ICAM‐1), vascular cell adhesion molecule‐1 (VCAM‐1), very late activation antigen‐4 (VLA‐4), lymphocyte function‐associated antigen 1 (LFA‐1) and macrophage antigen‐1 (Mac‐1) on eosinophil infiltration in the cutaneous late phase response (LPR) in OVA‐sensitized Balb/c mice by two approaches, immunostaining and inhibition assays with each monoclonal antibody. The eosinophil infiltration into the skin reached a peak at 12 hr after an intradermal challenge with OVA. Infiltrated eosinophils and mononuclear cells in the skin expressed Mac‐1 (eosinophils: 38.9 ± 1.55%, mononuclear cells: 51.2 ± 2.15%), LFA‐1 (eosinophils: 33.3 ± 0.95%, mononuclear cells: 23.1 ± 1.07%) and VLA‐4 (eosinophils: 14.3 ± 1.6%, mononuclear cells: 17.2 ± 1.38%) at 12 h. Intraperitoneal administration of anti‐mouse ICAM‐1, VCAM‐1, and VLA‐4 monoclonal antibodies (mAb) before the challenge decreased the eosinophil infiltration by 66.2%, 61.0%, and 54.0%, respectively. On the other hand, pretreatment with anti‐mouse LFA‐1 mAb or Mac‐1 mAb did not significantly decrease the infiltration.These results suggest that VCAM‐1/VLA‐4 interaction and ICAM‐1 play important roles in eosinophil infiltration in cutaneous LPR.
Diabetic Scleredema: A Case Report and Biochemical Analysis for Glycosaminoglycans
Authors: Kobayashi Takashi , Yamasaki Yuichiro , Watanabe Tomoo 
Published: April 2015

AbstractWe report a patient with the typical lesions of diabetic scleredema. Histological findings of the involved skin were thickening of the dermis, depositions of mucins, and fibrosis. Biochemical analysis revealed an increase in glycosaminoglycans in the involved skin as well as in the cutaneous lupus mucinosis. Mucinous materials were composed of hyaluronic acid.
A Case of Tuberous Sclerosis with a Giant Angiofibroma
Authors: Wataya‐Kaneda Mari , Yano Kenji , Hosokawa Ko , Yoshikawa Kunihiko 
Published: April 2015

AbstractThis is a case study of tuberous sclerosis with unusually large facial angiofibromas. The patient had other intense skin manifestations. Histological findings in the angiofibroma included large and glial‐appearing cells specific for this disease. Karyotype analysis revealed a translocation of chromosome (12q–, 15q+).
Dyschromatosis Universalis Hereditaria: An Electron Microscopic Examination
Authors: Kim Nam Soo , Im Sungbin , Kim Soo‐Chan 
Published: April 2015

AbstractWe report electron microscopic findings from both hyperchromic and achromic macules of dyschromatosis universalis hereditaria (DUH). The keratinocytes of the hyperchromic macules contained numerous, fully melanized melanosomes; almost all of them were aggregated to form the melanosome complex. In contrast, the melanosomes were absent from both keratinocytes and melanocytes of achromic macules, even though intact melanocytes were found. Our results suggest that DUH may be a disorder of melanosome production and distribution in epidermal melanin units rather than a disorder of melanocyte number.
Trichoblastoma with Rippled‐Pattern
Authors: Akasaka Toshihide , Imamura Yuko , Mori Yasuki , Iwasaki Masa , Kon Saiichi 
Published: April 2015

AbstractThe following is a case study of a 36‐year‐old Japanese man with a trichoblastoma which exhibited a rippled‐pattern on the left temporal region of the scalp. The histological findings of the tumor revealed lobular aggregations composed of immature follicular basaloid cells, lobules of squamous eddy‐like foci of incomplete keratinization or small keratinous cysts, and multiple papillary mesenchymal bodies similar to hair germ. Interestingly, a rippled‐pattern of basaloid cells and hyalinized matrixes resembling the Verocay bodies of neurilemmoma was also observed. We propose that the rippled‐pattern of the basaloid cells and hyalinized matrices is caused by the characteristic stromal induction of trichoblastoma.
A Case of Lyme Disease Diagnosed Serologically
Authors: Fujita Hiroshi , Ogusu Koji , Imaizumi Shunsuke , Masuzawa Toshiyuki , Yanagihara Yasutake 
Published: April 2015

AbstractA 57‐year‐old Japanese male developed erythema migrans, arthralgia, and neurological symptoms after mountain climbing in Nagano Prefecture. On ELISA, his serum reacted to Borrelia isolated from various sources. The patient's serum reacted with a 41 kilodalton protein which was reactive with monoclonal antibody H9724 specific to flagellin of Borrelia on Western blotting. He recovered after taking minocycline 200 mg daily for 2 weeks.
Nuchal Fibroma
Authors: Abraham Zeev , Rozenbaum Michael , Rosner Itzhak , Naschitz Yohanan , Boss Yohanan , Rosenmann Eliezer 
Published: April 2015

AbstractNuchal fibroma was diagnosed in a 54‐year‐old diabetic woman with a two year history of increased skin thickness of her low‐posterior neck and interscapular region, causing discomfort and limitation of neck and arm motion. Physical and laboratory examinations excluded further disorders. The patient was released, free from symptoms, after complete excision of the soft tissue tumor.
Melkersson‐Rosenthal Syndrome—A Challenge for Dermatologists to Participate in the Field of Oral Medicine
Authors: Hornstein Otto P. 
Published: April 2015

AbstractMelkersson‐Rosenthal syndrome (MRS) is a neuro‐muco‐cutaneous disorder involving remittently both the oro‐facial innervation and muco‐cutaneous tissues in a pathosis of complex origin characterized by recurrent edema, facial or other palsies, and nerval dysfunctions frequently assoiciated with plicated tongue. Biopsies taken from the edematous tissues often reveal a temporary pattern of moderate epitheloid granulomatous inflammation scattered scarcely within remarkable tissue edema. However, this histological pattern is not a prerequisite for the diagnosis of MRS. The disease usually runs an intermittent and unpredictable course over years or decades and may have, if the edemas involve the tongue or the central nervous system, an ambiguous outcome. Greatly disfiguring oro‐facial swellings often result from secondary persistence of the primarily recurrent edemas. A classification on grounds of different ‘major’ and ‘minor signs’ of MRS is proposed in the present paper. In recent years, novel therapeutic approaches involving either oral clofazimine or laser beam acupuncture (according to the principles of traditional Chinese medicine) have proven to be successful in some cases of MRS. Dermatology could play a larger role in oral medicine by taking diseases such as MRS into account in studies among specialties dealing with oro‐facial pathoses.