bluuebunny/crossref_metadata_2025_split huggingface dataset:
Facilitating design communication through engineering information traceability
Authors: Pavković Neven , Štorga Mario , Bojčetić Nenad , Marjanović Dorian 
Published: April 2013

AbstractTraceability of information provides the basis for assessing the credibility of engineering information, better understanding it, and making judgments about the appropriateness of its use for a particular design task. The presented research attempts to answer how the proposed traceability methodology and framework could help designers to improve communication, eventually create new channels of communication, and contribute to the creation of shared understanding in collaborative design processes. The discussion of these issues is based on a literature review, empirical research, observations of industrial practice, and feedback from initial implementation. The research is focused on information objects (IOs), archetypically represented in the engineering domain as technical documents that are often complex structures constituted of textual, numerical, and graphical fragments. The presented approach is based on an abstraction of IOs' relationships organized around specific contexts that are defined by a subset of product development ontology. Each IO could be repeatedly represented in various contexts that may contain different subsets of objects and their relationships. Such a representation also acts as a container in which the ontology concept instances are associated with IOs being developed and traced during the design episode. The usage of the proposed traceability methodology is discussed with examples of implementation and possible utilization situations. The paper is focused on explaining how the developed functionalities could help to resolve manifestations of inadequate information flow, which cause communication barriers in engineering companies. In addition, the proposed traceability methodology offers the possibility to record the detailed history of actions and events associated with IOs in the usage process of the product life cycle management systems. Based on the research findings, this paper argues that such a network of the traceability links and relationships may be viewed as a novel design communication channel.
Communicating actionable user research for human-centered design
Authors: Roschuni Celeste , Goodman Elizabeth , Agogino Alice M. 
Published: April 2013

AbstractIn human-centered design, user research drives design decisions by providing an understanding of end users. In practice, different people, teams, or even companies manage each step of the design process, making communication of user research results a critical activity. Based on an empirical study of current methods used by experts, this paper presents strategies for effectively communicating user research findings across organizational or corporate boundaries. To build researcher–client relationships, understand both user and client needs, and overcome institutional inertia, this paper proposes viewing user research clients asusersof user research outcomes. This reframing of the crafting of communication across boundaries as a parallel internal human-centered design process we refer to as adouble ethnography.
Articulating (mis)understanding across design discipline interfaces at a design team meeting
Authors: Luck Rachael 
Published: April 2013

AbstractCommunication is both the problem and the solution to misunderstanding. It is the human communicative ability to display understanding to resolve misunderstandings that plays an important part in the organization of the design inputs to a construction project. Ambiguity and uncertainty, as different forms of misunderstanding, are studied in this article, as they are manifest in the conversation at a design meeting. In this setting the coordination of bothin situdesign activities and the planning of design tasks takes place in real time, in conversation. Exhibited are several ways that design ambiguities and uncertainties can be seen in the interactional details of a multidisciplinary design team's conversation, to then report on how different design expertise featured in the raising of, and attempts at resolving, the misunderstandings that arose. In the course of this meeting, ambiguity and uncertainty were observed not as neat, discrete phenomena but were interwoven in the conversation. This characteristic poses difficulties in the disambiguation of the problem-solving response to each form of misunderstanding and further develops our understanding of design as it is communicated and conducted in social interaction. Finally, some implications from this study are put forward to inform the design of support for collaborative design.
Social learning in design teams: The importance of direct and indirect communications
Authors: Singh Vishal , Dong Andy , Gero John S. 
Published: April 2013

AbstractThis paper discusses the effects of direct and indirect communications on social learning and task coordination in design teams. The findings reported in this paper are based on a computational model that simulates the formation of transactive memory (TM) through social learning from direct and indirect communications. Direct communications are explicit information exchanged between team members whereas indirect communication may be opportunistic and coincidental, resulting in learning and information gained through observations of the actions of others. However, team structure mediates opportunities for communication. Three types of team structures are studied, which are differentiated on the basis of their constraints on and opportunities for direct and indirect communications across the team. The differences across the team structures are investigated through a series of simulations in which team member retention, cognitive busyness of team members, and task complexity are additional moderating variables, and task coordination and formation of TM are the dependent variables. Fewer communications to coordinate the same tasks are taken as the measure of efficient task coordination. Findings suggest that reduction in communication and learning opportunities are more detrimental to the task coordination in flat teams as compared to functional teams. Indirect communications contribute more to the formation of TM than to task coordination. Flat teams facilitate the formation of TM, whereas functional teams are more appropriate for efficient task coordination, indicating that the role of TM in mediating task coordination varies with team structure.
Portable Suction Unit Failure in a Rural EMS System
Authors: Risavi Brian L. , Sabotchick K. J. , Heile Christopher J. 
Published: April 2013

AbstractIntroductionPortable suction units used by EMS personnel are utilized infrequently and often are powered by batteries. Lack of use and inspection often results in failure of the device when it is needed. The purpose of this study was to examine the incidence of portable suction unit failure in a rural EMS system and to identify the reasons for failures.MethodsA convenience sample was obtained through both random inspections by the staff of a regional EMS council and data from twice monthly checks reported by respective EMS agencies following a standard protocol for each unit. A standard protocol was used, including checking the vacuum level on each suction unit and inspecting the tubing, canister, and battery. Each inspector assessed whether the unit was capable of achieving 300 mmHg of suction within four seconds. Also, the unit was inspected for any signs of misalignment or dry rot of the gasket, kinking of suction hose, damage to the suction canister, weak/dead battery, or defective pump. Findings were recorded.ResultsOver a two-year period, 9,631 suction unit inspections were completed. There were 233 failures (2.4%) noted. The majority (126, 54.1%) were due to battery failure. Seventy-three units failed due to other reasons (not recorded, switch failure, battery not seated). Ten inspections failed due to incorrect assembly. Nineteen inspections failed due to defects with the suction canister. Five inspections failed due to kinked/disconnected suction tubing.ConclusionOnly a relatively small percentage of inspections of suction units revealed failures (4.6% Advanced Life Support, 8.6% Basic Life Support) using the above-stated criteria. However, given the importance of airway management and potential complications associated with airway compromise, including aspiration pneumonia, hypoxia, and hemodynamic instability, this is of concern relative to the morbidity and mortality that could be related to airway failure. Due to the relative infrequency of use and the nature of portable suction units, the potential for lack of maintenance and deficiencies in routine inspection may impact the functional status of these devices in EMS agencies. Clearly, improved documentation of battery installation date, charging in accordance with manufacturer recommendations, and thorough inspection of the portable suction unit in its entirety will ensure readiness of these devices. Additionally, more rigorous documentation and analysis of inspections should be a focus of EMS agencies.RisaviBL,SabotchickKJ,HeileCJ.Portable suction unit failure in a rural EMS system.Prehosp Disaster Med.2013;28(4):1-3.
Dietary diversification for prevention of anaemia among women of childbearing age from rural India
Authors: Rao Shobha , Joshi Smita , Bhide Pradnya , Puranik Bhairavi , Asawari Kanade 
Published: April 2013

AbstractObjectiveTo assess the impact of an intervention modifying dietary habits for the prevention of anaemia in rural India.DesignIntervention study with data on anthropometric (weight, height) measurements, Hb and diet pattern. As per the cut-off for Hb in the government programme, women with Hb <11 g/dl had to be given Fe tablets and formed the supplemented group while those with Hb > 11 g/dl formed the non-supplemented group.SettingsThree villages near Pune city, Maharashtra, India.SubjectsRural non-pregnant women (n 317) of childbearing age (15–35 years).ResultsAfter 1 year of intervention, mean Hb increased (from 10·94 (sd 1·22) g/dl to 11·59 (sd 1·11) g/dl) significantly (P < 0·01) with a consequent reduction in the prevalence of anaemia (from 82·0 % to 55·4 %) as well as Fe-deficiency anaemia (from 30·3 % to 10·8 %). Gain in Hb was inversely associated with the initial level of Hb. Significant gain in Hb (0·57 g/dl) was observed among women attending >50 % of the meetings or repeating >50 % of the recipes at home (0·45 g/dl) in the non-supplemented group and was smaller than that observed in the supplemented group. Consumption of green leafy vegetables more than twice weekly increased substantially from 44·7 % to 60·6 %, as did consumption of seasonal fruits. Logistic regression showed that women with lower participation in the intervention had three times higher risk (OR = 3·08; 95 % CI 1·04, 9·13; P = 0·04) for no gain in Hb compared with those having high participation.ConclusionsDeveloping action programmes for improving nutritional awareness to enhance the consumption of Fe-rich foods has great potential for preventing anaemia in rural India.
Deep sequencing of non-ribosomal peptide synthetases and polyketide synthases from the microbiomes of Australian marine sponges
Authors: Woodhouse Jason N , Fan Lu , Brown Mark V , Thomas Torsten , Neilan Brett A 
Published: April 2013

Abstract
The biosynthesis of non-ribosomal peptide and polyketide natural products is facilitated by multimodular enzymes that contain domains responsible for the sequential condensation of amino and carboxylic subunits. These conserved domains provide molecular targets for the discovery of natural products from microbial metagenomes. This study demonstrates the application of tag-encoded FLX amplicon pyrosequencing (TEFAP) targeting non-ribosomal peptide synthetase (NRPS) and polyketide synthase (PKS) genes as a method for determining the identity and diversity of natural product biosynthesis genes. To validate this approach, we assessed the diversity of NRPS and PKS genes within the microbiomes of six Australian marine sponge species using both TEFAP and metagenomic whole-genome shotgun sequencing approaches. The TEFAP approach identified 100 novel ketosynthase (KS) domain sequences and 400 novel condensation domain sequences within the microbiomes of the six sponges. The diversity of KS domains within the microbiome of a single sponge species Scopalina sp. exceeded that of any previously surveyed marine sponge. Furthermore, this study represented the first to target the condensation domain from NRPS biosynthesis and resulted in the identification of a novel condensation domain lineage. This study highlights the untapped potential of Australian marine sponges for the isolation of novel bioactive natural products. Furthermore, this study demonstrates that TEFAP approaches can be applied to functional genes, involved in natural product biosynthesis, as a tool to aid natural product discovery. It is envisaged that this approach will be used across multiple environments, offering an insight into the biological processes that influence the production of secondary metabolites.
Sustained Savings from a Longitudinal Cost Analysis of an Internet-Based Preapproval Antimicrobial Stewardship Program
Authors: Sick Anna C. , Lehmann Christoph U. , Tamma Pranita D. , Lee Carlton K. K. , Agwu Allison L. 
Published: April 2013

Objective.To evaluate an internet-based preapproval antimicrobial stewardship program for sustained reduction in antimicrobial prescribing and resulting cost savings.Design.Retrospective cohort study and cost analysis.Methods.Review of all doses and charges of antimicrobials dispensed to patients over 6 years (July 1, 2005–June 30, 2011) at a tertiary care pediatric hospital.Results.Restricted antimicrobials account for 26% of total doses but 81% of total antimicrobial charges. Winter months (November–February) and the oncology and infant and toddler units were associated with the highest antimicrobial charges. Five restricted drugs accounted for the majority (54%) of charges but only 6% of doses. With an average approval rate of 91.5% (95% confidence interval [CI], 91.1%–91.9%), the preapproval antibiotic stewardship program saved $103,787 (95% CI, $98,583–$109,172) per year, or $14,156 (95% CI, $13,446–$14,890) per 1,000 patient-days.Conclusions.A preapproval antimicrobial stewardship program effectively reduces the number of doses and subsequent charges due to restricted antimicrobials years after implementation. Hospitals with reduced resources for implementing postprescription review may benefit from a preapproval antimicrobial stewardship program. Targeting specific units, drugs, and seasons may optimize preapproval programs for additional cost savings.
National Estimates of Central Line–Associated Bloodstream Infections in Critical Care Patients
Authors: Wise Matthew E. , Scott R. Douglas , Baggs James M. , Edwards Jonathan R. , Ellingson Katherine D. , Fridkin Scott K. , McDonald L. Clifford , Jernigan John A. 
Published: April 2013

Objective.Recent studies have demonstrated that central line-associated bloodstream infections (CLABSIs) are preventable through implementation of evidence-based prevention practices. Hospitals have reported CLABSI data to the Centers for Disease Control and Prevention (CDC) since the 1970s, providing an opportunity to characterize the national impact of CLABSIs over time. Our objective was to describe changes in the annual number of CLABSIs in critical care patients in the United States.Design.Monte Carlo simulation.Setting.US acute care hospitals.Patients.Nonneonatal critical care patients.Methods.We obtained administrative data on patient-days for nearly all US hospitals and applied CLABSI rates from the National Nosocomial Infections Surveillance and the National Healthcare Safety Network systems to estimate the annual number of CLABSIs in critical care patients nationally during the period 1990–2010 and the number of CLABSIs prevented since 1990.Results.We estimated that there were between 462,000 and 636,000 CLABSIs in nonneonatal critical care patients in the United States during 1990–2010. CLABSI rate reductions led to between 104,000 and 198,000 fewer CLABSIs than would have occurred if rates had remained unchanged since 1990. There were 15,000 hospital-onset CLABSIs in nonneonatal critical care patients in 2010; 70% occurred in medium and large teaching hospitals.Conclusions.Substantial progress has been made in reducing the occurrence of CLABSIs in US critical care patients over the past 2 decades. The concentration of critical care CLABSIs in medium and large teaching hospitals suggests that a targeted approach may be warranted to continue achieving reductions in critical care CLABSIs nationally.
CellH5: a format for data exchange in high-content screening
Authors: Sommer Christoph , Held Michael , Fischer Bernd , Huber Wolfgang , Gerlich Daniel W. 
Published: April 2013

Abstract
Summary: High-throughput microscopy data require a diversity of analytical approaches. However, the construction of workflows that use algorithms from different software packages is difficult owing to a lack of interoperability. To overcome this limitation, we present CellH5, an HDF5 data format for cell-based assays in high-throughput microscopy, which stores high-dimensional image data along with inter-object relations in graphs. CellH5Browser, an interactive gallery image browser, demonstrates the versatility and performance of the file format on live imaging data of dividing human cells. CellH5 provides new opportunities for integrated data analysis by multiple software platforms.
Availability: Source code is freely available at www.github.com/cellh5 under the GPL license and at www.bioconductor.org/packages/release/bioc/html/rhdf5.html under the Artistic-2.0 license. Demo datasets and the CellH5Browser are available at www.cellh5.org. A Fiji importer for cellh5 will be released soon.
Contact: daniel.gerlich@imba.oeaw.ac.at or christoph.sommer@imba.oeaw.ac.at
Supplementary information: Supplementary data are available at Bioinformatics online.
The Emergence of Political Accountability*
Authors: Bidner Chris , Francois Patrick 
Published: April 2013

Abstract
When and how do democratic institutions deliver accountable government? In addressing this broad question, we focus on the role played by political norms—specifically, the extent to which leaders abuse office for personal gain and the extent to which citizens punish such transgressions. We show how qualitatively distinct political norms can coexist because of a dynamic complementarity, in which citizens’ willingness to punish transgressions is raised when they expect such punishments to be used in the future. We seek to understand the emergence of accountability by analysing transitions between norms. To do so, we extend the analysis to include the possibility that, at certain times, a segment of voters are (behaviorally) intolerant of transgressions. Our mechanism highlights the role of leaders, offering an account of how their actions can instigate enduring change, within a fixed set of formal institutions, by disrupting prevailing political norms. We show how such changes do not depend on “sun spots” to trigger coordination, and are asymmetric in effect—a series of good leaders can (and eventually will) improve norms, whereas bad leaders cannot damage them.
Cognitive Changes after Saline or Plasmalyte Infusion in Healthy Volunteers
Authors: Story David A. , Lees Lucy , Weinberg Laurence , Teoh Soon-Yee , Lee Katherine J. , Velissaris Sarah , Bellomo Rinaldo , Wilson Sarah J. 
Published: April 2013

Abstract

Background:
In an incidental finding, during a study of plasma chemistry after crystalloid infusion, participants reported subjective cognitive changes, particularly slower thinking, after saline but not Hartmann’s (Ringer’s lactate) solution. The authors tested the hypothesis that saline infusion would produce greater adverse cognitive changes than Plasmalyte infusion.

Methods:
The authors conducted a randomized, cross-over, multiple blinded study of healthy adult volunteers. On separate days, participants received 30 ml/kg over 1 h of either 0.9% saline or Plasmalyte with the order randomly allocated. Plasma chemistry was tested on venous samples. As part of a battery of cognitive tests our primary endpoint was the reaction time index after infusion.

Results:
The authors studied 25 participants. Plasma chloride was greater after saline than after Plasmalyte: mean difference 5.4 mM (95% CI, 4.1–6.6 mM; P < 0.001). Saline was also associated with greater metabolic acidosis: base-excess 2.5 mM more negative (95% CI, 1.9–3.0 mM more negative; P < 0.001). There was no evidence of a difference in the reaction time index between the two interventions: mean reaction time index 394 ms (SD, 72) after saline versus 385 ms (SD, 55) after Plasmalyte. Difference: saline 9 ms slower (95% CI, 30 ms slower to 12 ms faster; P = 0.39). There were minimal differences in the other cognitive and mood tests.

Conclusions:
Despite expected differences in plasma chemistry, the authors found that measures of cognition did not differ after infusions of Plasmalyte or saline.
Changes in Blood Pressure and Cardiac Output during Cesarean Delivery
Authors: Rosseland Leiv Arne , Hauge Tor Hugo , Grindheim Guro , Stubhaug Audun , Langesæter Eldrid 
Published: April 2013

Abstract

Background:
Little is known about maternal hemodynamics after Cesarean delivery. Uterine contractions may increase cardiac output. Oxytocin is the first-line treatment for uterine atony, although the effects of the long-acting oxytocin analogue carbetocin are comparable with that of oxytocin. The authors analyzed the effects of i.v. oxytocin 5 U, carbetocin 100 µg, and placebo on hemodynamics, uterine tone, adverse events, and blood loss after Cesarean delivery.

Methods:
This was a randomized, double-blinded, placebo-controlled, parallel-group comparison of carbetocin and oxytocin after elective Cesarean delivery of singletons under spinal anesthesia (n = 76). Continuously measured invasive systolic arterial pressure was the primary outcome measure.

Results:
The mean systolic arterial pressure decrease was 28 mmHg (95% CI, 22–34) after oxytocin and 26 mmHg (95% CI, 20–31) after carbetocin. The decrease was greatest after 80 (95% CI, 71–89) and 63 s (95% CI, 55–72), respectively (P = 0.006). The differences were nearly undetectable after 2.5 min, although the effect of carbetocin was slightly greater than placebo (P < 0.001). The group differences in systolic arterial pressure decreased over 5 min and were gone at 1 h. Heart rate and cardiac output increased in all three groups. Stroke volume increased after oxytocin and carbetocin but was unchanged after placebo.

Conclusions:
The hemodynamic side effects of oxytocin 5 U and carbetocin 100 µg were comparable. The lack of an increase in stroke volume in the placebo group challenges the theory that uterine contraction causes autotransfusion of uterine blood, leading to an increase in preload.