bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jellyfish blooms - an overlooked hotspot and potential vector for the transmission of antimicrobial resistance in marine environments
Authors: Elena Alan X. , Orel Neža , Fang Peiju , Herndl Gerhard J. , Berendonk Thomas U. , Tinta Tinkara , Klümper Uli 
Published: July 2024

AbstractJellyfish, and gelatinous zooplankton (GZ) in general, represent an important component of marine food webs. Certain GZ species are capable of generating massive blooms of severe environmental impact. These blooms are often followed by a sudden collapse of the entire population, introducing considerable amounts of organic matter (GZ-OM) in the ocean’s interior. GZ-OM represents an abundant substrate to promote bacterial growth and copious colonizable surface for microbial interactions. Hence we hypothesized that this GZ-OM serves as a yet overlooked hotspot for transmitting antimicrobial resistance genes (ARGs) in marine environments. For this we experimentally evolved and analyzed marine microbial communities in microcosms in presence and absence of OM from scyphozoanAurelia auritas.l. and ctenophoreMnemiopsis leidyi. Communities evolved under GZ-OM exposure displayed an up to 4-fold increase in relative ARG and an up to 10-fold increase in abundance of horizontally transferable mobile genetic elements (MGEs) per 16S rRNA gene copy compared to the controls. This trait was consistent across ARG and MGE classes and independent of the GZ species, suggesting that the underlying mechanism is indeed based on the general influx of nutrients and colonizable surfaces. Potential ARG carriers included known key GZ-OM degraders, but also genera containing potential pathogens hinting towards an increased risk of ARG transfer to pathogenic strains. Here,Vibriowere pinpointed as potential key species directly associated with several significantly elevated ARGs and MGEs. Subsequent whole-genome sequencing of aVibrioisolate from the microcosm experiment revealed the genetic potential for the mobilization and transfer of ARGs in GZ-OM degrading microbial consortia. With this study, we established the first link between two emerging issues of marine coastal zones, jellyfish blooms and AMR spread, both likely increasing in projected future ocean scenarios.
Multi-omic profiling of intraductal papillary neoplasms of the pancreas reveals distinct expression patterns and potential markers of progression
Authors: Wang Yuefan , Lih T. Mamie , Lee Jae W. , Ohtsuka Takao , Hozaka Yuto , Mino-Kenudson Mari , Adsay N. Volkan , Luchini Claudio , Scarpa Aldo , Maker Ajay V. , Kim Grace E. , Paulino Jorge , Chen Lijun , Jiao Liyuan , Sun Zhenyu , Goodman Davina , Pflüger Michael J. , Roberts Nicholas J. , Matthaei Hanno , Wood Laura D. , Furukawa Toru , Zhang Hui , Hruban Ralph H. 
Published: July 2024

AbstractIn order to advance our understanding of precancers in the pancreas, 69 pancreatic intraductal papillary neoplasms (IPNs), including 64 intraductal papillary mucinous neoplasms (IPMNs) and 5 intraductal oncocytic papillary neoplasms (IOPNs), 32 pancreatic cyst fluid samples, 104 invasive pancreatic ductal adenocarcinomas (PDACs), 43 normal adjacent tissues (NATs), and 76 macro-dissected normal pancreatic ducts (NDs) were analyzed by mass spectrometry. A total of 10,246 proteins and 22,284 glycopeptides were identified in all tissue samples, and 756 proteins with more than 1.5-fold increase in abundance in IPMNs relative to NDs were identified, 45% of which were also identified in cyst fluids. The over-expression of selected proteins was validated by immunolabeling. Proteins and glycoproteins overexpressed in IPMNs included those involved in glycan biosynthesis and the immune system. In addition, multiomics clustering identified two subtypes of IPMNs. This study provides a foundation for understanding tumor progression and targets for earlier detection and therapies.SignificanceThis multilevel characterization of intraductal papillary neoplasms of the pancreas provides a foundation for understanding the changes in protein and glycoprotein expression during the progression from normal duct to intraductal papillary neoplasm, and to invasive pancreatic carcinoma, providing a foundation for informed approaches to earlier detection and treatment.
Exploring potential of AI usage in the knowledge and evidence services of a public health body: a working group approach
Authors: Simmons Zalaya , Bruce Charlotte , Thomas Samuel , Lacey Patricia , Marsh Wendy , Rosenberg Scott , Duval Daphne 
Published: July 2024

AbstractThe UK Health Security Agency (UKHSA)’s Knowledge and Library Services (KLS) established an Artificial Intelligence (AI) working group in 2022 to explore potential applications of AI of relevance to its function. This paper describes the working group’s approach to testing and evaluating AI and machine learning-assisted tools for information retrieval and evidence review processes, including duplicate reference removal, citation searching, title and abstract screening, full text screening, data extraction and critical appraisal. Initial tests have demonstrated varying degrees of potential for implementation, while also contributing to broader discussions on ethical considerations, copyright and licensing issues, transparency of AI methodology and evidence integrity. This overview outlines the methodology used and insights gained from navigating the rapidly evolving AI landscape and its potential implications for knowledge and library services within a public health organisation.
Knowledge, uptake and intention to use antibiotic post-exposure prophylaxis and meningococcal B vaccine (4CMenB) for gonorrhoea among a large, online community sample of gay, bisexual and other men who have sex with men in the UK
Authors: Ogaz Dana , Edney Jessica , Phillips Dawn , Mullen Dolores , Reid David , Wilkie Ruth , Buitendam Erna , Bell James , Lowndes Catherine M , Hughes Gwenda , Fifer Helen , Mercer Catherine H , Saunders John , Mohammed Hamish 
Published: July 2024

AbstractIntroductionNovel STI prevention interventions, including doxycycline post-exposure prophylaxis (doxyPEP) and meningococcal B vaccination (4CMenB) against gonorrhoea, have been increasingly examined as tools to aid STI control. There is emerging evidence of the efficacy of doxyPEP in preventing bacterial STIs; however limited data exist on the extent of use in the UK. We examined self-reported knowledge and use of antibiotic post-exposure prophylaxis (PEP), and intention to use (ITU) doxyPEP and 4CMenB among a large, community sample of gay, bisexual and other men who have sex with men (GBMSM) in the UK.MethodsUsing data collected by the RiiSH survey (November/December 2023), part of a series of online surveys of GBMSM in the UK, we describe (%, [95% CI]) self-reported knowledge and use of antibiotic PEP (including doxyPEP) and doxyPEP and 4CMenB ITU. Using bivariate and multivariable logistic regression, we examined correlates of ever using antibiotic PEP, doxyPEP ITU, and 4CMenB ITU, respectively, adjusting for sociodemographic characteristics and a composite marker of sexual risk defined as reporting (in the last three months): ≥5 condomless anal sex partners, bacterial STI diagnosis, chemsex, and/or meeting partners at sex-on-premises venues, sex parties, or cruising locations.ResultsOf 1,106 participants (median age: 44 years [IQR: 34-54]), 34% (30%-37%) knew of antibiotic PEP; 8% (6%-10%) ever reported antibiotic PEP use. Among those who did, most reported use in the last year (84%, 73/87) and exclusively used doxycycline (69%, 60/87). Over half of participants reported doxyPEP ITU (51% [47%-56%]) while over two-thirds (64% [60%-69%]) reported 4CMenB ITU. GBMSM with markers of sexual risk and with uptake of other preventative interventions were more likely to report ever using antibiotic PEP as well as doxyPEP and 4CMenB ITU, respectively. HIV-PrEP users and people living with HIV (PLWHIV) were more likely to report STI prophylaxis use and ITU than HIV-negative GBMSM not reporting recent HIV-PrEP use.DiscussionThere were high levels of intended use of novel STI prevention interventions. Fewer than one in ten GBMSM had reported ever using antibiotic PEP, with usage more common among those at greater risk of STIs. Future guidelines and health promotion for 4CMenB and antibiotic PEP must be carefully crafted alongside clinical experts and community partners, given intervention complexity and the risk of presenting conflicting public health messages regarding antimicrobial stewardship.
The protease ADAMTS5 controls ovarian cancer cell invasion, downstream of Rab25
Authors: Yuan Shengnan , Bacchetti Rachele , Adams Jamie , Rainero Elena 
Published: July 2024

AbstractOvarian cancer is the 3rdmost common gynaecological malignancy worldwide, with a 5-year survival rate of less than 30% in the presence of metastasis. Metastatic progression is characterised by extensive remodelling of the extracellular matrix, primarily mediated by secreted matrix metalloproteinases, including members of the ‘a disintegrin and metalloprotease with thrombospondin motif’ (ADAMTS) family. In particular, ADAMTS5 has been reported to be upregulated in ovarian malignant tumours compared to borderline and benign lesions, suggesting it might play a role in metastatic progression. Furthermore, it has been suggested that Rab25, a small GTPase of the Ras family, might upregulate ADAMTS5 expression in ovarian cancer cells. Here we demonstrated that Rab25 promotes ADAMTS5 expression, through the activation of the NF-κB signalling pathway. Furthermore, ADAMTS5 was necessary and sufficient to stimulate ovarian cancer cell migration through complex fibroblast-secreted matrices, while ADAMTS5 inhibition prevented ovarian cancer spheroid invasion in 3D systems. Finally, in ovarian cancer patients high ADAMTS5 expression correlated with poor prognosis. Altogether, these data identify ADAMTS5 as a novel regulator of ovarian cancer cell migration and invasion, suggesting it might represent a novel therapeutic target to prevent ovarian metastasis.
Tight quantum depth lower bound for solving systems of linear equations
Authors: Wang Qisheng , Zhang Zhicheng 
Published: July 2024

Since Harrow [A. W. Harrow, A. Hassidim, and S. Lloyd, ] showed that a system of linear equations with N variables and condition number κ can be solved on a quantum computer in poly[log(N),κ] time, exponentially faster than any classical algorithms, its improvements and applications have been extensively investigated. The state-of-the-art quantum algorithm for this problem is due to Costa [P. C. S. Costa, D. An, Y. R. Sanders, Y. Su, R. Babbush, and D. W. Berry, ], with optimal query complexity Θ(κ). An important question that is left is whether parallelism can bring further optimization. In this paper, we study the limitation of parallel quantum computing on this problem. We show that any quantum algorithm for solving systems of linear equations with time complexity poly[log(N),κ] has a lower bound of Ω(κ) on the depth of queries, which is tight up to a constant factor.

Published by the American Physical Society
2024
QCD critical point, Lee-Yang edge singularities, and Padé resummations
Authors: Başar Gökçe 
Published: July 2024

I analyze the trajectory of the Lee-Yang edge singularities of the QCD equation of state in the complex baryon chemical potential (μB) plane for different values of the temperature by using the recent lattice results for the Taylor expansion coefficients up to eighth order in μB and various resummation techniques that blend in Padé expansions and conformal maps. By extrapolating from this information, I estimate for the location of the QCD critical point: Tc≈100 MeV, μc≈580 MeV. I also estimate the crossover slope at the critical point to be α1≈9∘ and further constrain the nonuniversal mapping parameters between the three-dimensional Ising model and QCD equations of state.

Published by the American Physical Society
2024
Symmetries of spatial correlators of light and heavy mesons in high temperature lattice QCD
Authors: Chiu Ting-Wai 
Published: July 2024

The spatial z correlators of meson operators in Nf=2+1+1 lattice QCD with optimal domain-wall quarks at the physical point are studied for seven temperatures in the range of 190–1540 MeV. The meson operators include a complete set of Dirac bilinears (scalar, pseudoscalar, vector, axial vector, tensor vector, and axial-tensor vector), and each for six flavor combinations (u¯d, u¯s, s¯s, u¯c, s¯c, and c¯c). In a recent paper [], I focused on the meson correlators of u and d quarks, and discussed their implications for the effective restoration of SU(2)L×SU(2)R and U(1)A chiral symmetries, as well as the emergence of approximate SU(2)CS chiral spin symmetry. In this work, we extend our study to meson correlators of six flavor contents, and first observe the hierarchical restoration of chiral symmetries in QCD, from SU(2)L×SU(2)R×U(1)A to SU(3)L×SU(3)R×U(1)A, and to SU(4)L×SU(4)R×U(1)A, as the temperature is increased from 190 to 1540 MeV. Moreover, we compare the temperature windows for the emergence of the approximate SU(2)CS symmetry in light and heavy vector mesons, and find that the temperature windows are dominated by the (u¯c,s¯c,c¯c) sectors.

Published by the American Physical Society
2024
Decarbonisation at least cost: an analysis of the optimal portfolio of instruments
Authors: Álvarez Francisco , Arnedillo Óscar , Rodríguez Diego , Sanz Jorge 
Published: July 2024

Purpose
This paper aims to propose a methodology for assessing an optimal portfolio of investment instruments that minimise the social costs of decarbonising economic activity while improving the environmental objectives proposed in EU legislation.

Design/methodology/approach
The methodology defines the net social cost of decarbonisation related to a portfolio of four instruments: installation of solar PV and wind generation, thermal insulation of households and deployment of heat pumps. The social cost is minimised by restricting it to the minimum level of the targets proposed in the Spanish National Energy and Climate Plan to reduce greenhouse gas emissions, increase generation from renewable sources and reduce energy consumption. The empirical approach also includes differences between regions according to the expected effect for instruments.

Findings
The application of this methodology to the environmental objectives defined in the current Spanish National Energy and Climate Plan for 2030 concludes that it is clearly possible to reduce the social cost of decarbonisation while improving environmental performance through a reorientation of investment instruments. In this case, such a reorientation would be based on a minimisation of efforts in thermal insulation of households and a maximisation of measures aimed at the installation of heat pumps.

Originality/value
The paper proposes a novel methodology for a social cost assessment that improves the allocation of a portfolio of environmental instruments. This portfolio could be extended in further work to include instruments related to transport or support for industrial decarbonisation, such as the deployment of renewable hydrogen, among others.
The role of knowledge management to improve organizational performance through organizational ambidexterity within the uncertainties
Authors: Restuputri Dian Palupi , Masudin Ilyas , Septira Auraria Putri , Govindan Kannan , Widayat Widayat 
Published: July 2024

PurposeThis study highlights the significance of knowledge management in the relationship between organizational ambidexterity and organizational performance within the context of Indonesian SMEs.Design/methodology/approachThe study adopts a quantitative research approach, employing a survey questionnaire to collect data from a sample of SMEs operating in Indonesia. Structural Equation Modeling using Partial Least Square is used to investigate the relationship between variables.FindingsThe findings of this study show that in the context of small and medium enterprises, the variables of environmental and technological uncertainty are not driving factors in organizational ambidexterity. In contrast, market uncertainty has a significant effect on organizational ambidexterity. Moreover, it is also found that knowledge management does not support the variables of environmental, market, and technological uncertainty on organizational ambidexterity in small and medium enterprises. The results show that knowledge management plays a significant role in organizational ambidexterity. It also shows that knowledge management could support a significant way between organizational ambidexterity and organizational performance.Originality/valueThe findings of this study give insights for SMEs to attain a sustainable competitive edge in a dynamic business landscape by implementing efficient knowledge management techniques that bolster their ambidextrous capacities.
Unveiling the digital desire: UTAUT analysis of NFT investment intentions in Malaysia
Authors: Ramly Faezal Bin , Md Zabri Mohd Zaidi 
Published: July 2024

PurposeThis study pioneers the investigation into the determinants influencing Malaysian investors' intentions towards Non-Fungible Token (NFT) investments, utilizing an extended Unified Theory of Acceptance and Use of Technology (UTAUT) framework. It explores the burgeoning interest in NFTs within the Malaysian market, an emerging economy, and identifies the behavioral adoption determinants critical for NFT investment decisions.Design/methodology/approachAdopting a quantitative methodology, the research engaged 183 experienced Malaysian investors through a structured online questionnaire survey. The study employed regression analysis to assess the impact of Performance Expectancy, Effort Expectancy, Social Influence, Facilitating Conditions, Perceived Usefulness, Social Support and Perceived Trust on NFT investment intentions.FindingsThe findings reveal that Performance Expectancy and Social Support significantly predict the intention to invest in NFTs, accounting for 47% of the variance in investment intentions. The study highlights the crucial role of perceived benefits and community support in shaping Malaysian investors' engagement with NFTs, amidst the complexities of the digital asset landscape.Research limitations/implicationsThe study acknowledges the limitation posed by its sampling method and size, suggesting the need for broader investigations that include a more diverse demographic to enhance the generalizability of the findings. Future research could further delve into the specific behaviors, motivations and challenges of NFT investors and creators.Practical implicationsThe significant predictive power of Performance Expectancy indicates a primary financial motivation among Malaysian NFT investors, suggesting policymakers consider regulations that foster innovation and growth in the NFT sector while safeguarding investors. The study also underscores the importance of community support, pointing towards the development of platforms that facilitate knowledge sharing among NFT enthusiasts.Social implicationsBy demonstrating the pivotal role of social support in the NFT investment decision-making process, the research implies a powerful sense of community among investors in the digital asset space. It suggests the potential of NFTs to foster a more inclusive and accessible market for creative industry entrepreneurs, facilitating direct engagement and profit realization.Originality/valueThis research marks a significant departure from existing studies by tailoring the UTAUT model specifically to the NFT investment context in Malaysia. It unveils the nuanced dynamics influencing NFT investment intentions, emphasizing the unique contributions of Performance Expectancy and Social Support, thus providing a fresh perspective on NFT adoption in emerging markets.
The construction-related project management evolution and its future research directions
Authors: Russell Jeffrey S. , El-adaway Islam , Khalef Ramy , Salih Fareed , Ali Gasser 
Published: July 2024

PurposeProject management (PM) involves planning, allocating, directing and controlling project resources within a set of predetermined objectives. The modern definition of PM has evolved and grown into a broader concept. This paper supports the notion that PM evolved into four distinct phases: PM 1.0 is primarily concerned with planning, PM 2.0 with collaboration, PM 3.0 with proactive adaptation and PM 4.0 with using innovative technologies. Research efforts tackled critical aspects of PM, but none of them provided a clear foundation for the full context of PM principles and how they complement one another. This study fills this knowledge gap by investigating the evolution of PM over time.Design/methodology/approachThe authors collected a dataset of research papers between 1960 and 2022 and performed a bibliometric analysis on the collected dataset to isolate the main trends that define the evolution of PM phases.FindingsResults show that all PM phases overlap in terms of overarching themes, concepts, principles and contributions. More importantly, PM 5.0 may be around the corner to facilitate effective and efficient handling of time, cost, scope and risks within the ever-growing complexity of project initiatives.Originality/valueThis paper provides a data-driven study for a holistic understanding of the key trends in PM and the associated expectations of future research directions. This will be of interest to stakeholders within the overall PM domain and multidisciplinary work related to the construction industry.
Confronting social dominance ideology: how professional women manage career stereotypes in male-dominated occupations
Authors: Akanji Babatunde , Mordi Chima , Ajonbadi Hakeem Adeniyi 
Published: July 2024

PurposeUsing social dominance theory as a conceptual lens, this study explores how female managers and professionals strive to defy the perceived career stereotypes in traditionally male-dominated occupations.Design/methodology/approachThe dataset comprises 30 interviews with female bank managers and senior engineers in Nigeria – a non-Western location and work group – a sample that is considered under-researched.FindingsThe qualitative analysis identifies how the interviewed women adopted three strategies in managing gender and career stereotypes, with some expressing concerns of experiencing emotional dissonance as they contend with occupational segregation based on gender.Research limitations/implicationsThe extent to which the findings can be generalised may be constrained by the study’s limited sample size. Nevertheless, the findings shed light on the underlying importance of disclosing how working women exert themselves in navigating the social dominance ideology in Nigeria that is notable for extreme gender role differentiation. This often results in an intensification of the efforts made by female professionals in confronting the endemic nature of male chauvinism in Nigerian organisations.Originality/valueResearch on gender and career constraints has, in the main, restricted our understanding of the barriers that Nigerian women face in their careers as a result of the masculine hegemony perpetuated by social dominance. The present study aims to challenge, however, proponents of social dominance by unveiling the mitigating strategies that women living in an inegalitarian society adopt to confront occupational male-group ascendency.