bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Synthesis of Functionally Substituted Isoxazole and Isothiazole Derivatives.
Authors: Potkin V. I. , Petkevich S. K. , Kletskov A. V. , Dikusar E. A. , Zubenko Yu. S. , Zhukovskaya N. A. , Kazbanov V. V. , Pashkevich S. G. 
Published: April 2014

AbstractA variety of ester compounds containing two isoxazole moieties [cf.
ChemInform Abstract: Novel Pyrazole Integrated 1,3,4‐Oxadiazoles: Synthesis, Characterization and Antimicrobial Evaluation.
Authors: Ningaiah Srikantamurthy , Bhadraiah Umesha K. , Doddaramappa Shridevi D. , Keshavamurthy Shubakara , Javarasetty Chethan 
Published: April 2014

AbstractAmong the synthesized oxadiazole derivatives, compound (IIIh) emerges as an effective antimicrobial agent.
ChemInform Abstract: Hydromagnesite as an Efficient Recyclable Heterogeneous Solid Base Catalyst for the Synthesis of Flavanones, Flavonols and 1,4‐Dihydropyridines in Water.
Authors: Rajesh U. Chinna , Manohar Sunny , Rawat Diwan S. 
Published: April 2014

AbstractA form of hydromagnesite with flower‐like thin‐sheet morphology is prepared and successfully employed as the catalyst for the synthesis of flavones (II), flavonol (III) and the multicomponent synthesis of 1,4‐dihydropyridines (VII).
ChemInform Abstract: Synthesis of Phenylalkyl‐Substituted Polyhydroxypiperidines as Potent Inhibitors for α‐L‐Fucosidase.
Authors: Toyooka Naoki , et al. et al. 
Published: April 2014

AbstractKey intermediate (III) is converted into homologues (V) and (VIII) either by Lemieux—Johnson oxidation and subsequent Wittig reaction or in one step by Grubb metathesis, respectively.
ChemInform Abstract: Formation of Tryptanthrin Compounds upon Oxone‐Induced Dimerization of Indole‐3‐carbaldehydes.
Authors: Nelson Amber C. , Kalinowski Emily S. , Jacobson Taylor L. , Grundt Peter 
Published: April 2014

AbstractIn general, the synthesis of tryptanthrin derivatives by Oxone‐induced dimerization of the corresponding indole‐3‐carbaldehydes appears to be limited to 5‐halo substituted compounds.
ChemInform Abstract: Reaction of Arylenedioxytrihalophosphoranes with Acetylenes. Part 11. Electronic Effect of the Substituent in Arylacetylene on the Reaction Rate.
Authors: Mironov V. F. , et al. et al. 
Published: April 2014

AbstractReaction of 1,3,2‐dioxaphosphole derivative (I) with arylacetylene (II) affords phosphacoumarin derivative (III) (other examples are without yields).
ChemInform Abstract: Conversion of Phenols into Selenophenols: Seleno Newman—Kwart Rearrangement.
Authors: Soerensen Anne , Rasmussen Brian , Agarwal Shubham , Schau‐Magnussen Magnus , Soelling Theis I. , Pittelkow Michael 
Published: April 2014

AbstractThis rearrangement works best with electron‐withdrawing substituents in ortho‐ and/or para‐position due to a lower energy barrier of activation.
ChemInform Abstract: Preparation of C‐Arylglycals via Suzuki—Miyaura Cross‐Coupling of Dihydropyranylphosphates.
Authors: Leidy Michelle R. , Hoffman Mason J. , Pongdee Rongson 
Published: April 2014

AbstractThe Suzuki—Miyaura cross‐coupling of dihydropyranylphosphates with various arylboronate esters affords the corresponding arylated dihydropyrans including C‐arylated glycal (V).
ChemInform Abstract: Copper‐Catalyzed Domino Route to Natural Nostoclides and Analogues: A Total Synthesis of Nostoclides I (Ia) and II (Ib).
Authors: Ngi Samuel Inack , Petrignet Julien , Duwald Romain , El Hilali El Mostafa , Abarbri Mohamed , Duchene Alain , Thibonnet Jerome 
Published: April 2014

AbstractThe total synthesis is based on a two‐step sequence consisting of the Cu‐catalyzed tandem reaction associated with the Suzuki cross‐coupling reaction.
A novel method for monitoring tumor proliferation in vivo using fluorescent dye DiD
Authors: Yumoto Kenji , Berry Janice E. , Taichman Russell S. , Shiozawa Yusuke 
Published: April 2014

AbstractMonitoring single cell proliferation in vivo is difficult, but optimizing this technique is essential in order to expand our knowledge of the regulation of tumor proliferation. In this study, we used a lipophilic fluorescent dye, DiD, that rapidly and stably integrates into the phospholipid cell membrane. We cultured DiD‐stained prostate cancer cell lines for 10 days and isolated cells by flow cytometry based on expression levels of DiD. We found that a decrease in DiD intensity was correlated to the reduction of EdU, where the DiD‐high population proliferated more slowly than the DiD‐low population and the DiD‐low population exhibited a higher mitotic index. We also found that DiD was detected after 3 weeks of implantation in an in vivo setting. Importantly, DiD dye did not have any effect on normal cell growth, whereas a gold standard fluorescent dye for measuring cell proliferation, CFSE, slowed cell proliferation. Although further study is indicated, DiD can be useful for identifying the molecular mechanisms underlying tumor proliferation in vivo. © 2014 International Society for Advancement of Cytometry
Neutral Hexacoordinate Silicon(IV) Complexes with a Tridentate Dianionic O,N,X Ligand (X = O, N, S), Bidentate Monoanionic X,N Ligand (X = O, S), and Phenyl Ligand: Compounds with a SiO3N2C, SiSO2N2C, SiO2N3C, SiSON3C, or SiS2ON2C Skeleton
Authors: Weiß Jörg , Baus Johannes A. , Burschka Christian , Tacke Reinhold 
Published: April 2014

AbstractA series of neutral hexacoordinate silicon(IV) complexes (4a, 4b, 5a, 5b, 6a, and 6b) with a SiO3N2C, SiSO2N2C, SiO2N3C, SiSON3C, or SiS2ON2C skeleton have been synthesized and structurally characterized by solid‐state and solution NMR spectroscopy and single‐crystal X‐ray diffraction. These studies were performed with a special emphasis on comparing the respective O/NMe/S analogues 4a/5a/6a and 4b/5b/6b and the O/S pairs 4a/4b, 5a/5b, and 6a/6b with respect to their structures and NMR spectroscopic parameters.
1‐Methyl‐5‐(trifluoromethyl)azafulvenium Methide, an Intermediate That Undergoes Reaction through “Unusual” cis‐exo‐1,3‐ and trans‐exo‐1,7‐Cycloadditions
Authors: Peláez Walter José , Pepino Ana Julieta , Argüello Gustavo Alejandro , Pinho e Melo Teresa M. V. D. 
Published: April 2014

AbstractThe generation and reactivity of a new 1‐methyl‐5‐(trifluoromethyl)azafulvenium methide are described. Under microwave‐induced pyrolysis conditions this intermediate could be trapped by dipolarophiles, acting either as a 4π or as an 8π dipole. Quantum chemical calculations carried out at the DFT level of theory allowed the rationalization of the results observed in the cycloaddition of 1‐methyl‐5‐(trifluoromethyl)azafulvenium methide and N‐substituted maleimides. The study revealed that for 1,7‐cycloadducts the major products are obtained in the trans configuration through the unusual exo‐cycloaddition mode, whereas for 1,3‐cycloadducts the cis counterparts are obtained from this unexpected approach. In addition, under flash vacuum pyrolysis or conventional thermolysis conditions 1‐methyl‐5‐(trifluoromethyl)azafulvenium methide undergoes an allowed suprafacial sigmatropic [1,8]H shift leading to the formation of 2‐methyl‐3‐(trifluoromethyl)‐1‐vinyl‐1H‐pyrrole.
Effect of Electrostatic Interaction on Electrodeposition of Nickel Hexacyanoferrate with Functional MWCNTs and Their Application for the Determination of Persulfate and Tannic Acid
Authors: Tsai Tsung‐Hsuan , Yeh Pin‐Chun , Chen Shen‐Ming , Ali M. Ajmal , Al‐Hemaid Fahad M. A. 
Published: April 2014

AbstractA nanocomposite film of NiHCF electrodeposited onto AFCNT was modified on GCE by the electrostatic interaction of multiple scan cyclic voltammetry. Amino groups have been introduced with a positive charge onto the surface of MWCNTs. The presence of NiHCF‐AFCNT/GCE was characterized by using FE‐SEM, EDS, EIS, and XRD studies. The nanocomposite film of NiHCF‐AFCNT was further utilized to determine persulfate and tannic acid, respectively. The nanocomposite film modified electrode displays linear response from 0.1 to 19 mM and 10 to 170 µM for persulfate and tannic acid with a correlation coefficient of 0.9921 and 0.9869. The detection limits were found to be 0.1 mM and 1 µM, respectively. As results, the electrostatic interaction between positively charged metal ions, amino functionalized CNT and negatively charged hexacyanoferrate can be a new subject for many interesting applications.
Alzheimer Disease Biomarker Detection Through Electrocatalytic Water Oxidation Induced by Iridium Oxide Nanoparticles
Authors: Rivas Lourdes , de la Escosura‐Muñiz Alfredo , Pons Josefina , Merkoçi Arben 
Published: April 2014

AbstractIridium oxide nanoparticles (IrO2 NPs) synthesized following a previously reported chemical route are presented as novel tags for immunosensing taking advantage of their electrocatalytic activity towards water oxidation reaction (WOR). Cyclic voltammetry and chronoamperometry for the evaluation of the IrO2 NPs electrocatalytic activity towards WOR at neutral pH were used. The chronoamperometric current recorded at a fixed potential of +1.3 V constituted the analytical signal allowing the quantification of IrO2 NPs at nM levels. Modification of the surface of citrate‐capped IrO2 NPs with anti‐Apolipoprotein E antibodies (αApoE) was successfully achieved and the as‐prepared conjugates were used for the electrocatalytic detection of ApoE Alzheimer disease (AD) biomarker in a magnetosandwich immunoassay, reaching a detection limit of 68 ng/mL. Human plasma of a patient suffering AD was also evaluated, estimating an ApoE concentration of 20 µg/mL which is in concordance with the obtained in previously reported approaches. This novel IrO2 NPs based electrocatalytic assay presents the advantage of the signal generation in the same medium where the immunoassay takes place (PBS, pH 7.4) avoiding the use of additional reagents which also opens the way to future integrated biosensing systems and platforms with interest for other proteins as well as DNA and cells analysis.
Surprise beyond prediction error
Authors: Chumbley Justin R. , Burke Christopher J. , Stephan Klaas E. , Friston Karl J. , Tobler Philippe N. , Fehr Ernst 
Published: April 2014

AbstractSurprise drives learning. Various neural “prediction error” signals are believed to underpin surprise‐based reinforcement learning. Here, we report a surprise signal that reflects reinforcement learning but is neither un/signed reward prediction error (RPE) nor un/signed state prediction error (SPE). To exclude these alternatives, we measured surprise responses in the absence of RPE and accounted for a host of potential SPE confounds. This new surprise signal was evident in ventral striatum, primary sensory cortex, frontal poles, and amygdala. We interpret these findings via a normative model of surprise. Hum Brain Mapp 35:4805–4814, 2014. © 2014 The Authors. Human Brain Mapping Published by Wiley Periodicals, Inc.
The Volume‐Outcome Relationship and Minimum Volume Standards – Empirical Evidence for Germany
Authors: Hentschker Corinna , Mennicken Roman 
Published: April 2014

SummaryFor decades, there is an ongoing discussion about the quality of hospital care leading i.a. to the introduction of minimum volume standards in various countries. In this paper, we analyze the volume‐outcome relationship for patients with intact abdominal aortic aneurysm and hip fracture. We define hypothetical minimum volume standards in both conditions and assess consequences for access to hospital services in Germany. The results show clearly that patients treated in hospitals with a higher case volume have on average a significant lower probability of death in both conditions. Furthermore, we show that the hypothetical minimum volume standards do not compromise overall access measured with changes in travel times. Copyright © 2014 John Wiley & Sons, Ltd.
Pelvic floor muscle dysfunctions are prevalent in female chronic pelvic pain: A cross‐sectional population‐based study
Authors: Loving S. , Thomsen T. , Jaszczak P. , Nordling J. 
Published: April 2014

AbstractBackgroundNo current standardized set of pelvic floor muscle (PFM) outcome measures have been specifically tested for their applicability in a general female chronic pelvic pain (CPP) population. We aimed to compare PFM function between a randomly selected population‐based sample of women with CPP and age‐matched pain‐free controls using multiple standardized intravaginal examination measures recommended by the International Continence Society.MethodsThis was a cross‐sectional, population‐based and controlled study with randomly selected participants among women in Denmark. We reported blinded findings from a set of standardized vaginal PFM examination manoeuvres in 50 female participants (24 with CPP, 26 pain free). A preliminary pilot study ensured the intra‐ and intertester reliability of the test procedure. PFM outcomes were resting tone, relaxation capacity, strength, surface electromyographic activity and mechanosensitivity. Statistical analyses included unpaired t‐tests, Fisher's exact tests and Mann–Whitney tests.ResultsThe examination protocol was a reliable and predictable clinical measurement of associated PFM dysfunction in female CPP. Women with CPP had higher PFM resting tone and decreased maximal PFM strength and relaxation capacity compared with pain‐free controls. Enhanced PFM pressure‐pain sensitivity measured by palpometry during examination was also associated to CPP.ConclusionThis controlled, single‐blinded study with randomly selected participants provides new population‐based information regarding associated PFM dysfunction in women with CPP using multiple intravaginal examination methods. However, to identify women with CPP who will benefit from a physiotherapeutic specialized intervention, future prospective randomized controlled trials using these reliable and predictive outcomes are needed.
Evidence for central sensitization in patients with osteoarthritis pain: A systematic literature review
Authors: Lluch E. , Torres R. , Nijs J. , Van Oosterwijck J. 
Published: April 2014

AbstractHyperexcitability of the central nervous system (CNS) has been suggested to play an important role in the chronic pain experienced by osteoarthritis (OA) patients. A systematic review followingPRISMAguidelines was performed to evaluate the existing evidence from the literature related to the presence of central sensitization (CS) in patients withOA.Electronic databases PubMed and Web of Science were searched to identify relevant articles using pre‐defined keywords regardingCSandOA. Full‐text clinical reports addressing studies ofCSin human adults with chronic complaints due to osteoarthritis were included and screened for methodological quality by two independent reviewers. From the 40 articles that were initially eligible for methodological quality assessment, 36 articles achieved sufficient scores and therefore were discussed. The majority of these studies were case–control studies and addressedOAof the knee joint. Different subjective and objective parameters considered manifestations ofCS, which have been previously reported in other chronic pain conditions such as whiplash or rheumatoid arthritis, were established in subjects withOApain. Overall results suggest that, although peripheral mechanisms are involved inOApain, hypersensitivity of theCNSplays a significant role in a subgroup of subjects within this population. Although the majority of the literature provides evidence for the presence ofCSin chronicOApain, clinical identification and treatment ofCSinOAis still in its infancy, and future studies with good methodological quality are necessary.
Targeting of EGF‐displayed protein nanoparticles with anticancer drugs
Authors: Matsumoto Rie , Hara Rieko , Andou Takashi , Mie Masayasu , Kobatake Eiry 
Published: April 2014

AbstractThe development of protein‐based carriers for drug delivery has been well studied. We previously constructed a protein‐based nanoparticle consisting of genetically engineered elastin‐like polypeptides (ELPs) with a fused poly‐aspartic acid tail (ELPD). The size of the self‐assembled ELPD nanoparticles was regulated by charged repulsion of the poly‐aspartic acid chains. In the present study, epidermal growth factor (EGF) was genetically fused to the C‐terminus of ELPD to impart an active targeting ability to the ELPD nanoparticles. We examined the nanoparticle formation with EGF as well as its targeting ability. ELPD with fused EGF was found to form nanoparticles that displayed multivalent EGFs on their surface. EGF‐displayed nanoparticles loaded with the anti‐cancer drug paclitaxel were internalized into cells overexpressing the EGF receptor, and induced cell death. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1792–1798, 2014.
Synthesis, characterization and in vitro evaluation of cytotoxicity and antimicrobial activity of chitosan–metal nanocomposites
Authors: Kaur Pawan , Thakur Rajesh , Barnela Manju , Chopra Meenu , Manuja Anju , Chaudhury Ashok 
Published: April 2014

AbstractBACKGROUNDThe present study explores the synthesis of chitosan–metal nanocomposites in view of their increasing application as antimicrobial material.RESULTSChitosan nanoparticles were prepared by ionic gelation between chitosan and sodium tripolyphosphate. Copper sulphate hydrate (CuSO4.5H2O) and zinc acetate (Zn (O2CCH3)2) were used as precursors for synthesis of chitosan–copper nanocomposites (Cu/Ch) and chitosan–zinc nanocomposites (Zn/Ch), respectively. Synthesis of nanocomposites was confirmed by transmission electron microscopy (TEM), Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy with energy dispersive X‐ray microanalyses (SEM‐EDX) and differential scanning calorimetry (DSC). Cytotoxicity of nanoformulations was studied by Resazurin assay on Vero cell line (African green monkey kidney cell line). Their antibacterial activities were assessed by the zone of inhibition method and time dependent growth curve against Micrococcus luteus MTCC 1809, Pseudomonas aeruginosa MTCC 424 and Salmonella enterica MTCC 1253 in vitro. Antifungal activity was also studied against Alternaria alterneta, Rhizoctonia solani and Aspergillus flavus in vitro by the mycelium inhibition method.CONCLUSIONSIt was observed that all nanoformulations show high antimicrobial activity against all test microorganisms. So chitosan–metal complexes could be promising candidates for novel antimicrobial agents in cosmetic, food and textile industries. © 2014 Society of Chemical Industry
Investigation of selective arabinose release from corn fibre by acid hydrolysis under mild conditions
Authors: Fehér Csaba , Gazsó Zita , Tatijarern Patomwat , Molnár Máté , Barta Zsolt , Réczey Kati 
Published: April 2014

AbstractBACKGROUNDThe high cost of pure arabinose has resulted in a growing demand to develop new cost‐effective methods of arabinose production from lignocellulosic and pectin‐rich materials. Corn fibre is an inexpensive by‐product of the corn wet‐milling process, and is a promising raw material for producing arabinose and other value‐added products. In this study fast dilute sulphuric acid hydrolysis of corn fibre was investigated for selective arabinose solubilization. Acid concentration and reaction time of hydrolysis of destarched ground corn fibre and raw corn fibre were 0.25–5 w/w% at 5–15 min and 0.25–1.25 w/w% at 25–75 min, respectively. Results were evaluated statistically and model equations were developed to predict the yields of sugars.RESULTSIn the case of raw corn fibre the most favourable conditions were 1.1 w/w% sulphuric acid concentration and 51 min reaction time at 90°C, where a total arabinose yield of 75.9% was achieved with satisfactory selectivity. In the case of destarched ground corn fibre at a sulphuric acid concentration of 4.6 w/w%, a reaction time of 5 min and a temperature of 90°C, a total arabinose yield of 80.5% could be achieved with satisfactory selectivity, according to the model equations.CONCLUSIONArabinose‐rich liquid fractions were produced by mild sulphuric acid treatments of corn fibre. Based on the models developed the mono‐ and oligosaccharide contents of the hydrolysates can be controlled under the conditions investigated. © 2014 Society of Chemical Industry
Finite element method investigation of electrostatic precipitator performance
Authors: Hamou Nouri , Massinissa Aissou , Hakim Aitsaid , Youcef Zebboudj 
Published: April 2014

AbstractThis paper aims at analysis of the monopolar ionized field in electrostatic precipitator. A numerical model for simulating precipitation of particles in electrostatic precipitator is discussed in this paper. It includes all essential phenomena affecting the process.An iterative finite‐element technique is used to solve Poison's equation. We proposed the introduction of a potential corresponding to the critical minimum ionization field directly in the finite element formulation as a Dirichlet condition. The theoretical migration velocity is obtained by balancing the drag force with the Coulomb force or electrostatic force acting on a particle. We used the model introduced by Cochet for predicting a particle charge. The model assumes that a particle of the same size attains an equivalent maximum amount of charge for a charging time equal to infinity. Particles influence the electrical field, flow field, electrical migration velocity, gas discharge, particle charge and collection efficiency. Copyright © 2014 John Wiley & Sons, Ltd.
Ochratoxin A released back into the medium by Saccharomyces cerevisiae as a function of the strain, washing medium and fermentative conditions
Authors: Bevilacqua Antonio , Petruzzi Leonardo , Corbo Maria Rosaria , Baiano Antonietta , Garofalo Carmela , Sinigaglia Milena 
Published: April 2014

AbstractBACKGROUNDThis study was aimed at investigating the removal of ochratoxin A (OTA) by two wild strains of Saccharomyces cerevisiae (W20 and W30) in a semi‐synthetic medium under two temperatures (25, 30 °C) and sugar levels (200, 250 g L−1), as well as the stability of OTA–yeast complex by evaluating the amount of bound toxin released back after some washing treatments with phosphate‐buffered saline (PBS) or model wine (MW). In addition, the main products of fermentation were studied.RESULTSBoth W20 and W30 strains reduced OTA with removal percentages of 5.41–49.58%, and this process was affected by temperature and sugar concentration. Concerning the stability of the OTA–yeast complex, the amount of bound toxin decreased by 20–99% after five passes of washing, with a strong strain dependence and an effect of temperature and sugar concentration only for the W30 isolate. In addition, the two strains showed interesting technological properties in terms of fermentation products in a semi‐synthetic medium (high ethanol yield, volatile acidity as acetic acid < 1.2 g L−1; glycerol production exceeding 5.2 g L−1).CONCLUSIONSApart from the removal of OTA, release of the toxin is a variable process and relies upon the strain effect; a significance of the other factors of the design (sugar concentration, temperature) was found only for a single isolate. Thus evaluation of the stability of the complex yeasts/OTA should be an additional trait to select promising functional yeasts. © 2014 Society of Chemical Industry