bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pediatric tectal plate gliomas: clinical and radiological progression, MR imaging characteristics, and management of hydrocephalus
Authors: Griessenauer Christoph J. , Rizk Elias , Miller Joseph H. , Hendrix Philipp , Tubbs R. Shane , Dias Mark S. , Riemenschneider Kelsie , Chern Joshua J. 
Published: November 2013

Object
Tectal plate gliomas are generally low-grade astrocytomas with favorable prognosis, and observation of the lesion and management of hydrocephalus remain the mainstay of treatment.

Methods
A cohort of patients with tectal plate gliomas at 2 academic institutions was retrospectively reviewed.

Results
Forty-four patients with a mean age of 10.2 years who harbored tectal plate gliomas were included in the study. The mean clinical and radiological follow-up was 7.6 ± 3.3 years (median 7.9 years, range 1.5–14.7 years) and 6.5 ± 3.1 years (median 6.5 years, range 1.1–14.7 years), respectively. The most frequent intervention was CSF diversion (81.8% of patients) followed by biopsy (11.4%), radiotherapy (4.5%), chemotherapy (4.5%), and resection (2.3%). On MR imaging tectal plate gliomas most commonly showed T1-weighted isointensity (71.4%), T2-weighted hyperintensity (88.1%), and rarely enhanced (19%). The initial mean volume was 1.6 ± 2.2 cm3 and it increased to 2.0 ± 4.4 cm3 (p = 0.628) at the last follow-up. Frontal and occipital horn ratio (FOHR) and third ventricular width statistically decreased over time (p < 0.001 and p < 0.05, respectively).

Conclusions
The authors' results support existing evidence that tectal plate gliomas frequently follow a benign clinical and radiographic course and rarely require any intervention beyond management of associated hydrocephalus.
Risk factors for intraoperative lateral mass fracture of lateral mass screw fixation in the subaxial cervical spine
Authors: Inoue Shinichi , Moriyama Tokuhide , Tachibana Toshiya , Okada Fumiaki , Maruo Keishi , Horinouchi Yutaka , Yoshiya Shinichi 
Published: November 2013

ObjectAlthough lateral mass screw fixation for the cervical spine is a safe technique, lateral mass fracture during screw fixation is occasionally encountered intraoperatively. This event is regarded as a minor complication; however, it poses difficulties in management that may affect fixation stability and clinical outcome. The purpose of this study is to determine the incidence and etiology of lateral mass fractures during cervical lateral mass screw fixation.MethodsA retrospective clinical review of patient records was performed in 117 consecutive patients (mean age 57 years, range 15–86 years) who underwent lateral mass screw fixation using a modified Magerl method from 1997 to 2010 at a single institution. A total of 555 lateral masses were included in this study. The outer diameters of the screws were 3.5 or 4.0 mm. In the retrospective clinical analysis, the incidence of intraoperative lateral mass fractures was reviewed. Potential risk factors for this complication were assessed using multivariate analysis.ResultsThe incidence of lateral mass fractures during cervical lateral mass screw fixation was 4.7% (26 lateral masses) among all cases. Among the disorders, the incidence was highest in patients with destructive spondyloarthropathy (DSA) (18.8%, 12 lateral masses). There was no significant difference with respect to lateral mass fracture between the use of 4.0-mm screws (5.6%) and 3.5-mm screws (3.6%). Independent risk factors identified by logistic regression were DSA (OR 7.89, p < 0.001) and screw insertion in the C-6 lateral masses (OR 2.80, p = 0.018).ConclusionsThe overall incidence of lateral mass fracture during cervical lateral mass screw fixation was 4.7%. Destructive spondyloarthropathy as an underlying cause of morbidity and screw placement in the C-6 lateral mass were identified as independent risk factors. Use of a 4.0-mm screw in patients with DSA may be a principal risk factor for this complication.
Integrating Holocaust Research
Authors: Blanke Tobias , Kristel Conny 
Published: November 2013

In this article we present our ideas for an integrating activity for archival research on the Holocaust. We analyse how we can improve Holocaust-related collection descriptions for research, which we will make available online, and how EHRI provides travel grants for transnational access to existing infrastructures in Holocaust research. Both approaches help us overcome that Holocaust-related material is geographically dispersed and address the challenges for historical research stemming from the way documentation on the Holocaust has been attempted up to now. We have chosen to implement the EHRI integrated information resource using graph databases. With their emphasis on relationships, graph databases are particularly well suited for historical research in particular and humanities research in general. We analyse the architecture and implementation details of this novel approach and show how graph databases integrate with traditional ways of searching and browsing historical collections. This way, we support more advanced means of access to facts in the documents and enable deep semantically meaningful access to the documents. The innovation of EHRI lies in the combination of digital and non-digital means to integrate existing infrastructures. We believe this might be a model for many related research activities in the humanities.
Former pour entretenir et développer la créativité de l'entreprise : les leçons du Cirque du Soleil
Authors: Massé David , Paris Thomas 
Published: November 2013

Cet article présente les particularités et les enjeux de la formation des athlètes-artistes du Cirque du Soleil. Il dévoile les coulisses d’une transformation propre à l’entreprise : le passage de l’athlète à l’artiste. Ce cas illustre comment une organisation peut préserver et améliorer sa créativité grâce à la formation de ses recrues. À travers cette recherche, nous mettons en avant les conditions de succès à respecter pour favoriser l’intégration et le plein engagement du personnel dans une culture de créativité : faire de la formation pour accompagner le développement de l’entreprise, favoriser le développement personnel à travers la créativité dans une tâche spécifique, mettre l’accent sur la pratique, construire une culture de la rétroaction incitative et lutter contre l’érosion des apprentissages.
Gérer les idées pour mieux innover
Authors: Harvey Jean-François , Naggar Raouf , Cohendet Patrick , Simon Laurent 
Published: November 2013

Les gestionnaires sont de plus en plus convaincus que la génération et le développement d’idées représentent des enjeux prioritaires pour l’organisation. Gérer stratégiquement les idées permet à leur organisation d’innover plus souvent, plus rapidement ou plus radicalement. Cela peut contribuer, d’une part, à maintenir des parts de marché ou à en gagner de nouvelles et, d’autre part, à diminuer les coûts d’investissement, de maintenance et d’exploitation. Cependant, les modalités de la gestion des idées demeurent floues. Se basant sur l’étude d’une initiative de gestion des idées menée à l’Institut de recherche d’Hydro-Québec et sur la littérature dans ce domaine, cet article présente les paradoxes et les défis de la gestion des idées, puis décrit quatre propositions pour relever ces défis : commencer par les questions courantes ; accepter l’existence d’un réservoir tacite, le stimuler et savoir l’utiliser ; assurer la cohérence des systèmes ; transformer les ateliers de partage en occasions de briller.
In-Hospital Mortality Prediction in Patients Receiving Mechanical Ventilation in Taiwan
Authors: Chen Chao-Ju , Shi Hon-Yi , Lee King-Teh , Huang Tzuu-Yuan 
Published: November 2013

Background
Few studies have used pooled data for more than 2 years and few have analyzed data for patients receiving mechanical ventilation in Taiwan.

Objective
To validate the use of an artificial neural network model for predicting in-hospital mortality in patients receiving mechanical ventilation in Taiwan and to compare the predictive accuracy of the artificial neural network model with that of a logistic regression model.

Methods
Retrospective comparison of 1000 pairs of data sets processed by logistic regression and artificial neural network models based on initial clinical data for 213 945 patients receiving mechanical ventilation. For each pair of artificial neural network and logistic regression models, the area under the receiver operating characteristic curves, Hosmer-Lemeshow statistics, and accuracy rate were calculated and compared by using t tests. Global sensitivity analysis and sensitivity score approach were also used to assess the relative significance of input parameters in the system model and the relative importance of variables.

Results
Compared with the logistic regression model, the artificial neural network model had a better accuracy rate in 96.3% of cases, better Hosmer-Lemeshow statistics in 41.2% of cases, and a better area under the curve in 97.6% of cases. Hospital volume was the most influential (sensitive) variable affecting in-hospital mortality, followed by Charlson comorbidity index, length of stay, and hospital type.

Conclusions
Compared with the conventional logistic regression model, the artificial neural network model was more accurate in predicting in-hospital mortality and had higher overall performance indices.
Regulatory T Cells Suppress the Late Phase of the Immune Response in Lymph Nodes through P-Selectin Glycoprotein Ligand-1
Authors: Angiari Stefano , Rossi Barbara , Piccio Laura , Zinselmeyer Bernd H. , Budui Simona , Zenaro Elena , Della Bianca Vittorina , Bach Simone D. , Scarpini Elio , Bolomini-Vittori Matteo , Piacentino Gennj , Dusi Silvia , Laudanna Carlo , Cross Anne H. , Miller Mark J. , Constantin Gabriela 
Published: October 2013

Abstract
Regulatory T cells (Tregs) maintain tolerance toward self-antigens and suppress autoimmune diseases, although the underlying molecular mechanisms are unclear. In this study, we show that mice deficient for P-selectin glycoprotein ligand-1 (PSGL-1) develop a more severe form of experimental autoimmune encephalomyelitis than wild type animals do, suggesting that PSGL-1 has a role in the negative regulation of autoimmunity. We found that Tregs lacking PSGL-1 were unable to suppress experimental autoimmune encephalomyelitis and failed to inhibit T cell proliferation in vivo in the lymph nodes. Using two-photon laser-scanning microscopy in the lymph node, we found that PSGL-1 expression on Tregs had no role in the suppression of early T cell priming after immunization with Ag. Instead, PSGL-1-deficient Tregs lost the ability to modulate T cell movement and failed to inhibit the T cell–dendritic cell contacts and T cell clustering essential for sustained T cell activation during the late phase of the immune response. Notably, PSGL-1 expression on myelin-specific effector T cells had no role in T cell locomotion in the lymph node. Our data show that PSGL-1 represents a previously unknown, phase-specific mechanism for Treg-mediated suppression of the persistence of immune responses and autoimmunity induction.
Little Peptide, Big Effects: The Role of LL-37 in Inflammation and Autoimmune Disease
Authors: Kahlenberg J. Michelle , Kaplan Mariana J. 
Published: November 2013

Abstract
The innate immune system utilizes many approaches for defense against invading microorganisms, including complement-mediated lysis, engulfment, formation of neutrophil extracellular traps, and release of antimicrobial peptides. Although classically thought to be driven by adaptive immunity, the development of autoimmune diseases such as rheumatoid arthritis and systemic lupus erythematosus is increasingly associated with dysregulated innate immune pathways. An emerging theme within this literature is the contribution of antimicrobial peptides to the development of autoimmune disorders. This is best exemplified in atopic dermatitis and psoriasis where the defensins and the single human cathelicidin, LL-37, may contribute to disease. Furthermore, in the past few years, a role for LL-37 has emerged in the pathogenesis of systemic lupus erythematosus, rheumatoid arthritis, atherosclerosis, and possibly other diseases. In this review, we discuss the role of LL-37 and its murine ortholog, mCRAMP, in the modulation of immune and inflammatory pathways and their effects on autoimmune and inflammatory diseases.
Cardiovascular Risk Factors in Women With Primary Sjögren's Syndrome: United Kingdom Primary Sjögren's Syndrome Registry Results
Authors: Juarez M. , Toms T. E. , de Pablo P. , Mitchell S. , Bowman S. , Nightingale P. , Price E. J. , Griffiths B. , Hunter J. , Gupta M. , Bombardieri M. , Sutcliffe N. , Pitzalis C. , Pease C. , Andrews J. , Emery P. , Regan M. , Giles I. , Isenberg D. , Moots R. , Collins K. S. , Ng W. F. , Kitas G. D. ,   on behalf of the UK Primary Sjögren's Syndrome Registry
Published: October 2013

ObjectiveTo determine the prevalence of traditional cardiovascular risk factors using established definitions in a large cohort of clinically well‐characterized primary Sjögren's syndrome (SS) patients and to compare them to healthy controls.MethodsData on cardiovascular risk factors in primary SS patients and controls were collected prospectively using a standardized pro forma. Cardiovascular risk factors were defined according to established definitions. The prevalence of cardiovascular risk factors in the primary SS group was determined and compared to that in the control group.ResultsPrimary SS patients had a higher prevalence of hypertension (28–50% versus 15.5–25.6%; P < 0.01) and hypertriglyceridemia (21% versus 9.5%; P = 0.002) than age‐ and sex‐matched healthy controls. Furthermore, a significant percentage (56%) of hypertensive patients expected to be on antihypertensive treatment according to best practice was not receiving it.ConclusionPrimary SS patients are more than 2 times more likely to experience hypertension and hypertriglyceridemia than age‐ and sex‐matched healthy controls. Additionally, hypertension is underdiagnosed and suboptimally treated in primary SS.
Structure and mechanical properties of novel composites based on glycidyl azide polymer and propargyl‐terminated polybutadiene as potential binder of solid propellant
Authors: Ding Youzhao , Hu Chong , Guo Xiang , Che Yuanyuan , Huang Jin 
Published: October 2013

ABSTRACTInstead of the traditional isocyanate curing system as the binder of solid propellant, a triazole curing system has been developed by the reaction of azide group and alkynyl group due to a predominant advantage of avoiding to the interference of humidity. In this work, the propargyl‐terminated polybutadiene (PTPB) was blended with glycidyl azide polymers (GAPs) to produce new composites under the catalysis of cuprous chloride at ambient temperature. The triazole‐crosslinked network structure was regulated by changing the molar ratio of azide group in GAP versus alkynyl group in PTPB, and hence various crosslinked densities together with the composition changes of GAP versus PTPB cooperatively determined the mechanical properties of the resultant composites. Furthermore, the formed triazole‐crosslinked network derived from the azide group in GAP and alkynyl group in PTPB resulted in the slight increase of glass transition temperatures and a‐transition temperatures, and improved the miscibility between GAP and PTPB. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40007.
Dual action bactericides: Quaternary ammonium/N‐halamine‐functionalized cellulose fiber
Authors: Hu Bojian , Chen Xiaoqin , Zuo Yan , Liu Zuliang , Xing Xiaodong 
Published: October 2013

ABSTRACTBi‐functional antibacterial material was prepared by co‐grafting N‐halamine and quaternary ammonium salt monomers from cellulose fiber. The grafted fiber was characterized by Fourier transform infrared spectra, and X‐ray photoelectron spectra. The N‐halamine derived from the precursor 4‐[(acryloxy)methyl]‐4‐ethyl‐2‐oxazolidinone via chlorination treatment and the oxidative chlorine (Cl+) leaching behavior were investigated. The antibacterial activities of singly (only QAs‐functionalized or only Cl+‐releasing) and dual (QAs‐functionalized and Cl+‐releasing) functional cellulose fibers were tested against Gram‐negative Escherichia coli and Gram‐positive Staphylococcus aureus. Compared to singly functionalized formulations, the bi‐functional cellulose fiber exhibited excellent and rapid bactericidal performance against both E. coli and S. aureus. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40070.
Fractographic analysis of the crack resistance of styrene–acrylonitrile/polybutadiene‐g‐styrene–acrylonitrile blends as evaluated by the essential work of fracture method
Authors: Mazidi Majid Mehrabi , Razavi Aghjeh Mir Karim , Abbasi Farhang 
Published: October 2013

ABSTRACTThe fracture surfaces and deformation micromechanisms of styrene‐co‐acrylonitrile (SAN)/polybutadiene‐g‐styrene‐co‐acrylonitrile (PB‐g‐SAN) blends with the compositions ranging from 65/35 to 0/100 were studied with a scanning electron microscopy technique. The results were compared to the essential work of fracture parameters obtained in a previous study conducted on double‐edge notched tension specimens. Different plastic damage mechanisms were observed, and they depended on the blend composition. For blends of 65/35 and 45/55, a high degree of rubber particle cavitation and multiple cracking followed by the massive shear yielding of the matrix were found to be the main source of energy dissipation during crack growth. Within this compositional range, more intense plastic damage in a larger volume of material, especially at the notched region, was observed as the concentration of the rubbery phase increased. For the 25/75 blend, the prevailing mechanism was pure shear yielding without any sign of cavitation inside the particles, and the fracture surface became relatively flat and was covered with aligned small microcracks. This sample showed the highest specific essential work (we) value among the blends examined in the previous study. For the samples containing concentrations of dispersed phase higher than 75%, the shear yielding process gradually became less important with the progressive importance of multiple crazing so that high‐magnification micrographs revealed extensive microcracking/crazing both inside and between the rubber particles, as the only active deformation micromechanism for neat PB‐g‐SAN. The variation we and specific plastic work of fracture with the PB‐g‐SAN phase content were successfully explained in terms of prevalent deformation mechanisms. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40072.
Imide‐containing ladder polyphenylsilsesquioxanes with high thermal stability and thermoplastic properties
Authors: Chavez Ricardo , Ionescu Emanuel , Fasel Claudia , Riedel Ralf 
Published: October 2013

AbstractThis work reports for the first time the synthesis of ladder polyphenylsilsesquioxanes containing imide building blocks as parts of the main parallel chains. The ladder structure of the synthesized polymers was documented by means of small angle X‐ray scattering (SAXS) measurements. The obtained ladder polymers exhibit stability with respect to decomposition up to temperatures as high as 460°C; additionally, they have melting points far below their decomposition temperatures, which make them interesting candidate materials for thermoplastic processing. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40085.
Brief Report: Risk of Adverse Fetal Outcomes Associated With Immunosuppressive Medications for Chronic Immune‐Mediated Diseases in Pregnancy
Authors: Cooper William O. , Cheetham T. Craig , Li De‐Kun , Stein C. Michael , Callahan S. Todd , Morgan Thomas M. , Shintani Ayumi K. , Chen Ning , Griffin Marie R. , Ray Wayne A. 
Published: October 2013

ObjectiveTo assess the risk of adverse fetal outcomes following exposure to individual immunosuppressive drugs in pregnant women with chronic immune‐mediated diseases.MethodsHealth plan data were obtained from the Tennessee Medicaid and Kaiser Permanente Northern California and Southern California claims databases, with linkage to both vital records and medical records. Women with inflammatory arthropathies, those with systemic lupus erythematosus, and those with inflammatory bowel disease who filled prescriptions for immunosuppressive treatments during pregnancy were included. Major congenital malformations, fetal deaths, and life‐threatening neonatal complications were identified from the electronic data and validated with medical record review.ResultsThe cohort included 608 infants, including 437 with exposure to immunosuppressive drugs during the mother's pregnancy (402 during the first trimester, and 35 during the second and third trimester only) and 171 whose mothers filled prescriptions for immunosuppressive treatments before, but not during, pregnancy. There were 25 pregnancies (4.1% of the cohort) with confirmed major congenital malformations, and 10 fetal deaths (1.6% of the cohort). Among 113 preterm infants with exposures during pregnancy, 23 (20.4%) had life‐threatening neonatal complications, and among 485 term infants, 10 (2.1%) had life‐threatening complications. Compared to the reference group (treatment before, but not during, pregnancy), the risk ratios (RRs) for adverse fetal outcomes associated with immunosuppressive treatments (by exposure category) during pregnancy included the following: methotrexate (RR 1.39, 95% confidence interval [95% CI] 0.43–4.53), tumor necrosis factor inhibitors (RR 0.98, 95% CI 0.38–2.55), hydroxychloroquine (RR 1.33, 95% CI 0.69–2.55), and other immunosuppressive medications (RR 0.98, 95% CI 0.48–1.98).ConclusionIn this study, there was no evidence of a large increase in risk of adverse fetal outcomes from first‐trimester exposure to immunosuppressive medications, although the confidence intervals for the risk ratios were wide. Further studies will be needed as use of these medications increases over time.
A magnetic nanobead‐based bioassay provides sensitive detection of single‐ and biplex bacterial DNA using a portable AC susceptometer
Authors: Strömberg Mattias , Zardán Gómez de la Torre Teresa , Nilsson Mats , Svedlindh Peter , Strømme Maria 
Published: October 2013

AbstractBioassays relying on magnetic read‐out using probe‐tagged magnetic nanobeads are potential platforms for low‐cost biodiagnostic devices for pathogen detection. For optimal assay performance it is crucial to apply an easy, efficient and robust bead‐probe conjugation protocol. In this paper, sensitive (1.5 pM) singleplex detection of bacterial DNA sequences is demonstrated in a portable AC susceptometer by a magnetic nanobead‐based bioassay principle; the volume‐amplified magnetic nanobead detection assay (VAM‐NDA). Two bead sizes, 100 and 250 nm, are investigated along with a highly efficient, rapid, robust, and stable conjugation chemistry relying on the avidin–biotin interaction for bead‐probe attachment. Avidin‐biotin conjugation gives easy control of the number of detection probes per bead; thus allowing for systematic investigation of the impact of varying the detection probe surface coverage upon bead immobilization in rolling circle amplified DNA‐coils. The existence of an optimal surface coverage is discussed. Biplex VAM‐NDA detection is for the first time demonstrated in the susceptometer: Semi‐quantitative results are obtained and it is concluded that the concentration of DNA‐coils in the incubation volume is of crucial importance for target quantification. The present findings bring the development of commercial biodiagnostic devices relying on the VAM–NDA further towards implementation in point‐of‐care and outpatient settings.