bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early therapy with neuraminidase inhibitors for influenza A (H1N1) pdm 2009 infection
Authors: Yamamoto Takehisa , Ihashi Mai , Mizoguchi Yoshimi , Kaneno Hiroshi , Yamamoto Katsusuke , Inoue Yutaka , Kase Tetsuo , Okabe Nobuhiko , Shimotsuji Tsunesuke 
Published: June 2013

AbstractBackgroundNeuraminidase inhibitors have been reported to decrease mortality in patients infected with influenza A (H1N1) pdm 2009 (H1N1 pdm09), but it is not clear whether they are effective againstH1N1pdm09 in apparently healthy children.MethodsThe effect of early treatment with neuraminidase inhibitors on 70 otherwise healthy children with possible H1N1 pdm09 (pH1N1pdm09) infection was investigated. The children were simultaneously treated with a neuraminidase inhibitor (oseltamivir or zanamivir) and maoto, a Japanese traditional herbal medicine, which had been reported to be effective against seasonal influenza. Clinical severity was assessed using patient history, namely the worst values for clinical vital signs and laboratory data on admission. After refining these parameters with univariate, decision tree and multiple regression analysis, mean covariance structure equation analysis was used to investigate the association of estimated clinical severity to the selected parameters.ResultsTotal path analysis using a Bayesian method indicated that the estimated clinical severity of pH1N1pdm09 was positively associated with maximum body temperature, pulse rate, respiration rate, duration necessary for defervescence, admission duration and log urinary β2‐microglobulin/creatinine level, and negatively associated with age and the presence and duration of treatment with the neuraminidase inhibitor in the outpatient clinic.ConclusionsThis study provides the first clinical evidence that early treatment with neuraminidase inhibitors in outpatient clinic decreased the estimated clinical severity of pH1N1pdm09 in apparently otherwise healthy pediatric inpatients.
USDA Conservation Practices Increase Carbon Storage and Water Quality Improvement Functions: An Example from Ohio
Authors: Marton John M. , Fennessy M. Siobhan , Craft Christopher B. 
Published: June 2013

AbstractWe compared potential denitrification and phosphorus (P) sorption in restored depressional wetlands, restored riparian buffers, and natural riparian buffers of central Ohio to determine to what extent systems restored under the U.S. Department of Agriculture's Wetland Reserve Program (WRP) and Conservation Reserve Program (CRP) provide water quality improvement benefits, and to determine which practice is more effective at nutrient retention. We also measured soil nutrient pools (organic C, N, and P) to evaluate the potential for long‐term C sequestration and nutrient accumulation. Depressional wetland soils sorbed twice as much P as riparian soils, but had significantly lower denitrification rates. Phosphorus sorption and denitrification were similar between the restored and natural riparian buffers, although all Natural Resources Conservation Service (NRCS) practices had higher denitrification than agricultural soils. Pools of organic C (2570–3320 g/m2), total N (216–243 g/m2), and total P (60–71 g/m2) were comparable among all three NRCS practices but were greater than nearby agricultural fields and less than natural wetlands in the region. Overall, restored wetlands and restored and natural riparian buffers provide ecosystem services to the landscape that were lost during the conversion to agriculture, but the delivery of services differs among conservation practices, with greater N removal by riparian buffers and greater P removal by wetlands, attributed to differences in landscape position and mineral soil composition. At the landscape, and even global level, wetland and riparian restoration in agricultural landscapes will reintroduce multiple ecosystem services (e.g. C sequestration, water quality improvement, and others) and should be considered in management plans.
Oral health delivery systems for older adults and people with disabilities
Authors: Helgeson Michael , Glassman Paul 
Published: June 2013

ABSTRACTThis article describes new oral health care system models designed to meet the needs of a rapidly growing population of older adults and people with disabilities. These populations are not currently able to access traditional dental offices and clinics to the same degree that younger and much healthier population groups do. So new models proactively target specific community organizations where these high‐risk underserved population groups live, work, go to school, or obtain other health or social services. Collaborative on‐site and clinic‐based teams establish “Virtual Dental Homes” that provide ongoing, year‐round access to oral health services designed to prevent mouth infections, deliver evidence‐based preventive care, and restore infected individuals to stable and sustainable oral health. These new delivery models are beginning to demonstrate better health care delivery, better health outcomes, and the potential to drive down total health care costs for older adults and people with disabilities.
Immunization in End‐Stage Renal Disease: Opportunity to Improve Outcomes
Authors: Soni Ritu , Horowitz Bruce , Unruh Mark 
Published: June 2013

AbstractInfection is the second most common cause of death in patients with end‐stage renal disease (ESRD), following cardiovascular causes. Immunization is a fairly simple, but underutilized, strategy for prevention of infectious morbidity and mortality in patients with kidney failure. It is imperative for nephrologists and primary care providers to have an understanding of immunization as an essential component of preventive healthcare measures in this high‐risk population. Patients with ESRD represent a unique population due to their immunosuppressed state, dialysis‐related exposures and suboptimal response to routine vaccines. While the Advisory Committee on Immunization Practices (ACIP) provides guidelines for vaccination of patients with renal disease against Hepatitis B, influenza and pneumococcal disease, the data on immunization against other commonly preventable infectious diseases are lacking. This article reviews the recent evidence on immunization in the ESRD population and synthesizes the related implications for maximizing prevention of infectious diseases in this high‐risk population.
Emotion and Leadership: What Scholarship on Status and Identity Can Tell Us
Authors: Rogalin Christabel L. , Hirshfield Laura E. 
Published: June 2013

AbstractWhile leadership and emotion have been described as interrelated by many scholars in disciplines outside of sociology, there is a dearth of sociological literature on the subject. Indeed, within the last thirty years there has been an immense upsurge in the organizational literature on this very topic. While sociologists have not focused as much on leadership and emotions, there are many ways that sociologists can contribute, both empirically and theoretically. In this review our aim is to highlight the existing literatures within sociology that we feel are most valuable in exploring leadership and emotion, specifically, status and identity processes, while also engaging with the more developed literatures in organizations, focusing on the area of emotional regulation and labor.
Citizenship on the Margins: A Critique of Scholarship on Marginalized Women and Community Activism
Authors: Kim Nadia Y. 
Published: June 2013

AbstractThis critical review essay addresses the underappreciation of citizenship inequalities in scholarship on marginalized women’s community activism in the United States. Although both students of citizenship and women’s grassroots resistance argue that neither citizenship nor lived experience is an individual‐level phenomenon or a public issue divorced from private troubles and that politics need not be formal and male, the two literatures do not break bread with each other. I contend that this lack of cross‐pollination owes to our fixation on the hallowed trifecta of race, class, gender intersectionality, but one that has elided the fact that the three have always constituted, and been constituted by, citizenship. Despite the fact that in recent decades immigrant women of color have taken the helm of community campaigns – such as in social reproduction (e.g. schools, churches, health), Environmental Justice, and immigration reform – few scholars mention citizenship and thus few analyze citizenship racism and its ties to other axes of inequality. I critique the existing scholarship by drawing on the contributions of the few works that analyze and intersect citizenship within women’s community resistance struggles. I then point to future research directions to underscore their importance in an age of more exclusionary and draconian citizenship paradigms.
Consumer Responses to the Carbon Labelling of Food: A Real Life Experiment in a Canteen Practice
Authors: Spaargaren Gert , van Koppen C.S.A. (Kris) , Janssen Anke M. , Hendriksen Astrid , Kolfschoten Corine J. 
Published: June 2013

AbstractThe emerging debate on the climate impact of food is expected to result in the carbon labelling of food in the future. As yet, consumer responses to carbon labels are not well researched. A real life experiment was developed to study consumer responses to new carbon labels for food. A ‘light’ and a ‘comprehensive’ carbon labelling regime were stepwise introduced into the food practice of ‘having lunch in a canteen’. The resulting shifts in the behaviour and attitudes of regular canteen visitors were measured with the use of both quantitative and qualitative methods. Despite their overall positive attitude towards climate change policies, the canteen visitors show clear resistance to some of the changes suggested, especially when new courses of action run counter to the dynamics of the existing routinised practice. Using practice theory as our reference, we discuss the role of information provision next to other policy instruments for facilitating behavioural changes towards low carbon food consumption.
Association of HLA‐G 3′ untranslated region polymorphisms with antibody response against Plasmodium falciparum antigens: preliminary results
Authors: Sabbagh A. , Courtin D. , Milet J. , Massaro J. D. , Castelli E. C. , Migot‐Nabias F. , Favier B. , Rouas‐Freiss N. , Moreau P. , Garcia A. , Donadi E. A. 
Published: June 2013

AbstractHost and Plasmodium interactions result in highly variable clinical phenotypes, partly explained by the nature and level of anti‐malarial antibody response. Human leukocyte antigen (HLA)‐G can create a tolerogenic environment, allowing parasites to escape from anti‐malarial immunity. We performed a family‐based association study encompassing 483 Sereer individuals (261 children and their parents), and reported two independent signals at the HLA‐G 3′ untranslated region associated with antibody response to specific Plasmodium falciparum blood stage antigens, previously associated with malaria protection: (i) +3010G together with +3142C with total IgG and IgG1 against GLURP and (ii) +3196G with IgG3 against MSP2. While these results require further investigation, they suggest for the first time a role of HLA‐G in the regulation of humoral immune response in malaria.
Arabidopsis CHROMOSOME TRANSMISSION FIDELITY 7 (AtCTF7/ECO1) is required for DNA repair, mitosis and meiosis
Authors: Bolaños‐Villegas Pablo , Yang Xiaohui , Wang Huei‐Jing , Juan Chien‐Ta , Chuang Min‐Hsiang , Makaroff Christopher A. , Jauh Guang‐Yuh 
Published: June 2013

SummaryThe proper transmission of DNA in dividing cells is crucial for the survival of eukaryotic organisms. During cell division, faithful segregation of replicated chromosomes requires their tight attachment, known as sister chromatid cohesion, until anaphase. Sister chromatid cohesion is established during S‐phase in a process requiring an acetyltransferase that in yeast is known as Establishment of cohesion 1 (Eco1). Inactivation of Eco1 typically disrupts chromosome segregation and homologous recombination‐dependent DNA repair in dividing cells, ultimately resulting in lethality. We report here the isolation and detailed characterization of two homozygous T‐DNA insertion mutants for the Arabidopsis thaliana Eco1 homolog, CHROMOSOME TRANSMISSION FIDELITY 7/ESTABLISHMENT OF COHESION 1 (CTF7/ECO1), called ctf7‐1 and ctf7‐2. Mutants exhibited dwarfism, poor anther development and sterility. Analysis of somatic tissues by flow cytometry, scanning electron microscopy and quantitative real‐time PCR identified defects in DNA repair and cell division, including an increase in the area of leaf epidermal cells, an increase in DNA content and the upregulation of genes involved in DNA repair including BRCA1 and PARP2. No significant change was observed in the expression of genes that influence entry into the endocycle. Analysis of meiocytes identified changes in chromosome morphology and defective segregation; the abundance of chromosomal‐bound cohesion subunits was also reduced. Transcript levels for several meiotic genes, including the recombinase genes DMC1 and RAD51C and the S‐phase licensing factor CDC45 were elevated in mutant anthers. Taken together our results demonstrate that Arabidopsis CTF7/ECO1 plays important roles in the preservation of genome integrity and meiosis.
Systematics and biogeography of the arcuate horseshoe bat species complex (Chiroptera, Rhinolophidae)
Authors: Patrick Lorelei E. , McCulloch Eve S. , Ruedas Luis A. 
Published: June 2013

The present study sheds light on species delimitation in what has been previously described as Rhinolophus arcuatus, a morphologically conservative bat species complex nominally distributed throughout archipelagic South‐East Asia from New Guinea to Sumatra. Given that rhinolophids tend to be relatively weak fliers, hence have low vagility, we hypothesized that some specimens attributed to R. arcuatus, but originating from geographically disjunct populations, may in fact represent distinct species. To test this hypothesis, we examined specimens attributed to R. arcuatus as well as to other species in the Rhinolophus euryotis species group using both morphological techniques and mitochondrial cytochrome b and control region sequences. Careful morphological analysis reveals heretofore cryptic but nevertheless distinct, species‐level morphological differences among specimens derived from geographically isolated locations. Furthermore, molecular data illuminate the existence of several species‐level sequence divergences among specimens heretofore attributed to R. arcuatus. These analyses similarly suggest the existence of additional species in other South‐East Asian Rhinolophus taxa previously considered monotypic. We suggest at least one description to be undertaken of a previously unrecognized species as well as the elevation of several others from sub‐specific to specific status.
Adoption of Radial Access and Comparison of Outcomes to Femoral Access in Percutaneous Coronary Intervention
Authors: Feldman Dmitriy N. , Swaminathan Rajesh V. , Kaltenbach Lisa A. , Baklanov Dmitri V. , Kim Luke K. , Wong S. Chiu , Minutello Robert M. , Messenger John C. , Moussa Issam , Garratt Kirk N. , Piana Robert N. , Hillegass William B. , Cohen Mauricio G. , Gilchrist Ian C. , Rao Sunil V. 
Published: June 2013

Background—
Radial access for percutaneous coronary intervention (r-PCI) is associated with reduced vascular complications; however, previous reports have shown that <2% of percutaneous coronary intervention (PCI) procedures in the United States are performed via the radial approach. Our aims were to evaluate temporal trends in r-PCI and compare procedural outcomes between r-PCI and transfemoral PCI.

Methods and Results—
We conducted a retrospective cohort study from the CathPCI registry (n=2 820 874 procedures from 1381 sites) between January 2007 and September 2012. Multivariable logistic regression models were used to evaluate the adjusted association between r-PCI and bleeding, vascular complications, and procedural success, using transfemoral PCI as the reference. Outcomes in high-risk subgroups such as age ≥75 years, women, and patients with acute coronary syndrome were also examined. The proportion of r-PCI procedures increased from 1.2% in quarter 1 2007 to 16.1% in quarter 3 2012 and accounted for 6.3% of total procedures from 2007 to 2012 (n=178 643). After multivariable adjustment, r-PCI use in the studied cohort of patients was associated with lower risk of bleeding (adjusted odds ratio, 0.51; 95% confidence interval, 0.49–0.54) and lower risk of vascular complications (adjusted odds ratio, 0.39; 95% confidence interval, 0.31–0.50) in comparison with transfemoral PCI. The reduction in bleeding and vascular complications was consistent across important subgroups of age, sex, and clinical presentation.

Conclusions—
There has been increasing adoption of r-PCI in the United States. Transradial PCI now accounts for 1 of 6 PCIs performed in contemporary clinical practice. In comparison with traditional femoral access, transradial PCI is associated with lower vascular and bleeding complication rates.
Prevalence of commonly prescribed medications potentially contributing to urinary symptoms in a cohort of older patients seeking care for incontinence
Authors: Kashyap Mandavi , Tu Le Mai , Tannenbaum Cara 
Published: June 2013

Abstract

Background
Several medication classes may contribute to urinary symptoms in older adults. The purpose of this study was to determine the prevalence of use of these medications in a clinical cohort of incontinent patients.

Methods
A cross-sectional study was conducted among 390 new patients aged 60 years and older seeking care for incontinence in specialized outpatient geriatric incontinence clinics in Quebec, Canada. The use of oral estrogens, alpha-blocking agents, benzodiazepines, antidepressants, antipsychotics, ACE inhibitors, loop diuretics, NSAIDs, narcotics and calcium channel blockers was recorded from each patient’s medication profile. Lower urinary tract symptoms and the severity of incontinence were measured using standardized questionnaires including the International Consultation on Incontinence Questionnaire. The type of incontinence was determined clinically by a physician specialized in incontinence. Co-morbidities were ascertained by self-report. Logistic regression analyses were used to detect factors associated with medication use, as well as relationships between specific medication classes and the type and severity of urinary symptoms.

Results
The prevalence of medications potentially contributing to lower urinary tract symptoms was 60.5%. Calcium channel blockers (21.8%), benzodiazepines (17.4%), other centrally active agents (16.4%), ACE inhibitors (14.4%) and estrogens (12.8%) were most frequently consumed. Only polypharmacy (OR = 4.9, 95% CI = 3.1-7.9), was associated with medication use contributing to incontinence in analyses adjusted for age, sex, and multimorbidity. No associations were detected between specific medication classes and the type or severity of urinary symptoms in this cohort.

Conclusion
The prevalence of use of medications potentially causing urinary symptoms is high among incontinent older adults. More research is needed to determine whether de-prescribing these medications results in improved urinary symptoms.
Flavokawain B, a kava chalcone, inhibits growth of human osteosarcoma cells through G2/M cell cycle arrest and apoptosis
Authors: Ji Tao , Lin Carol , Krill Lauren S , Eskander Ramez , Guo Yi , Zi Xiaolin , Hoang Bang H 
Published: June 2013

AbstractBackgroundOsteosarcoma (OS) is the most common primary bone malignancy with a high propensity for local invasion and distant metastasis. Limited by the severe toxicity of conventional agents, the therapeutic bottleneck of osteosarcoma still remains unconquered. Flavokawain B (FKB), a kava extract, has been reported to have significant anti-tumor effects on several carcinoma cell lines bothin vitroandin vivo. Its efficacy and low toxicity profile make FKB a promising agent for use as a novel chemotherapeutic agent.ResultsIn the current study, we investigated the anti-proliferative and apoptotic effects of FKB against human osteosarcomas. Exposure of OS cells to FKB resulted in apoptosis, evidenced by loss of cell viability, morphological changes and the externalization of phosphatidylserine. Apoptosis induced by FKB resulted in activation of Caspase-3/7, -8 and −9 in OS cell lines, 143B and Saos-2. FKB also down-regulated inhibitory apoptotic markers, including Bcl-2 and Survivin and led to concomitant increases in apoptotic proteins, Bax, Puma and Fas. Therefore, the induction of apoptosis by FKB involved both extrinsic and intrinsic pathways. FKB also caused G2/M phase cell cycle arrest, which was observed through reductions in the levels of cyclin B1, cdc2 and cdc25c and increases in Myt1 levels. Furthermore, migration and invasion ability was decreased by FKB in a dose-dependent manner. The cytotoxicity profile showed FKB had significant lower side effects on bone marrow cells and small intestinal epithelial cells compared with Adriamycin.ConclusionsTaken together, our evidence of apoptosis and cell cycle arrest by FKB treatment with less toxicity than the standard treatments provides an innovative argument for the use of FKB as a chemotherapeutic and chemopreventive compound.In vivoexperiments utilizing FKB to reduce tumorigenesis and metastatic potential will be crucial to further justify clinical application.
EpCAM overexpression prolongs proliferative capacity of primary human breast epithelial cells and supports hyperplastic growth
Authors: Martowicz Agnieszka , Rainer Johannes , Lelong Julien , Spizzo Gilbert , Gastl Guenther , Untergasser Gerold 
Published: June 2013

Abstract

Introduction
The Epithelial Cell Adhesion Molecule (EpCAM) has been shown to be strongly expressed in human breast cancer and cancer stem cells and its overexpression has been supposed to support tumor progression and metastasis. However, effects of EpCAM overexpression on normal breast epithelial cells have never been studied before. Therefore, we analyzed effects of transient adenoviral overexpression of EpCAM on proliferation, migration and differentiation of primary human mammary epithelial cells (HMECs).

Methods
HMECs were transfected by an adenoviral system for transient overexpression of EpCAM. Thereafter, changes in cell proliferation and migration were studied using a real time measurement system. Target gene expression was evaluated by transcriptome analysis in proliferating and polarized HMEC cultures. A Chicken Chorioallantoic Membrane (CAM) xenograft model was used to study effects on in vivo growth of HMECs.

Results
EpCAM overexpression in HMECs did not significantly alter gene expression profile of proliferating or growth arrested cells. Proliferating HMECs displayed predominantly glycosylated EpCAM isoforms and were inhibited in cell proliferation and migration by upregulation of p27KIP1 and p53. HMECs with overexpression of EpCAM showed a down regulation of E-cadherin. Moreover, cells were more resistant to TGF-β1 induced growth arrest and maintained longer capacities to proliferate in vitro. EpCAM overexpressing HMECs xenografts in chicken embryos showed hyperplastic growth, lack of lumen formation and increased infiltrates of the chicken leukocytes.

Conclusions
EpCAM revealed oncogenic features in normal human breast cells by inducing resistance to TGF-β1-mediated growth arrest and supporting a cell phenotype with longer proliferative capacities in vitro. EpCAM overexpression resulted in hyperplastic growth in vivo. Thus, we suggest that EpCAM acts as a prosurvival factor counteracting terminal differentiation processes in normal mammary glands.