bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recommendations for Human Epidermal Growth Factor Receptor 2 Testing in Breast Cancer: American Society of Clinical Oncology/College of American Pathologists Clinical Practice Guideline Update
Authors: Wolff Antonio C. , Hammond M. Elizabeth H. , Hicks David G. , Dowsett Mitch , McShane Lisa M. , Allison Kimberly H. , Allred Donald C. , Bartlett John M.S. , Bilous Michael , Fitzgibbons Patrick , Hanna Wedad , Jenkins Robert B. , Mangu Pamela B. , Paik Soonmyung , Perez Edith A. , Press Michael F. , Spears Patricia A. , Vance Gail H. , Viale Giuseppe , Hayes Daniel F. 
Published: October 2013

PurposeTo update the American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guideline recommendations for human epidermal growth factor receptor 2 (HER2) testing in breast cancer to improve the accuracy of HER2 testing and its utility as a predictive marker in invasive breast cancer.MethodsASCO/CAP convened an Update Committee that included coauthors of the 2007 guideline to conduct a systematic literature review and update recommendations for optimal HER2 testing.ResultsThe Update Committee identified criteria and areas requiring clarification to improve the accuracy of HER2 testing by immunohistochemistry (IHC) or in situ hybridization (ISH). The guideline was reviewed and approved by both organizations.RecommendationsThe Update Committee recommends that HER2 status (HER2 negative or positive) be determined in all patients with invasive (early stage or recurrence) breast cancer on the basis of one or more HER2 test results (negative, equivocal, or positive). Testing criteria define HER2-positive status when (on observing within an area of tumor that amounts to > 10% of contiguous and homogeneous tumor cells) there is evidence of protein overexpression (IHC) or gene amplification (HER2 copy number or HER2/CEP17 ratio by ISH based on counting at least 20 cells within the area). If results are equivocal (revised criteria), reflex testing should be performed using an alternative assay (IHC or ISH). Repeat testing should be considered if results seem discordant with other histopathologic findings. Laboratories should demonstrate high concordance with a validated HER2 test on a sufficiently large and representative set of specimens. Testing must be performed in a laboratory accredited by CAP or another accrediting entity. The Update Committee urges providers and health systems to cooperate to ensure the highest quality testing. This guideline was developed through a collaboration between the American Society of Clinical Oncology and the College of American Pathologists and has been published jointly by invitation and consent in both Journal of Clinical Oncology and the Archives of Pathology & Laboratory Medicine. Copyright © 2013 American Society of Clinical Oncology and College of American Pathologists. All rights reserved. No part of this document may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopy, recording, or any information storage and retrieval system, without written permission by American Society of Clinical Oncology or College of American Pathologists.
Randomized Trial of Hypofractionated External-Beam Radiotherapy for Prostate Cancer
Authors: Pollack Alan , Walker Gail , Horwitz Eric M. , Price Robert , Feigenberg Steven , Konski Andre A. , Stoyanova Radka , Movsas Benjamin , Greenberg Richard E. , Uzzo Robert G. , Ma Charlie , Buyyounouski Mark K. 
Published: October 2013

Purpose To determine if escalated radiation dose using hypofractionation significantly reduces biochemical and/or clinical disease failure (BCDF) in men treated primarily for prostate cancer. Patients and Methods Between June 2002 and May 2006, men with favorable- to high-risk prostate cancer were randomly allocated to receive 76 Gy in 38 fractions at 2.0 Gy per fraction (conventional fractionation intensity-modulated radiation therapy [CIMRT]) versus 70.2 Gy in 26 fractions at 2.7 Gy per fraction (hypofractionated IMRT [HIMRT]); the latter was estimated to be equivalent to 84.4 Gy in 2.0 Gy fractions. High-risk patients received long-term androgen deprivation therapy (ADT), and some intermediate-risk patients received short-term ADT. The primary end point was the cumulative incidence of BCDF. Secondarily, toxicity was assessed. Results There were 303 assessable patients with a median follow-up of 68.4 months. No significant differences were seen between the treatment arms in terms of the distribution of patients by clinicopathologic or treatment-related (ADT use and length) factors. The 5-year rates of BCDF were 21.4% (95% CI, 14.8% to 28.7%) for CIMRT and 23.3% (95% CI, 16.4% to 31.0%) for HIMRT (P = .745). There were no statistically significant differences in late toxicity between the arms; however, in subgroup analysis, patients with compromised urinary function before enrollment had significantly worse urinary function after HIMRT. Conclusion The hypofractionation regimen did not result in a significant reduction in BCDF; however, it is delivered in 2.5 fewer weeks. Men with compromised urinary function before treatment may not be ideal candidates for this approach.
Managing Retention in Service Relationships
Authors: Aflaki Sam , Popescu Ioana 
Published: October 2013

In a repeat business context, past experiences with a service provider affect customers' decisions to renew their contract. How should a strategic firm manage customized service over time to maximize the long-term value from each customer relationship? We propose a dynamic model that relies on behavioral theories and empirical evidence to capture the effect of past service experiences on service quality expectations, customer satisfaction, and retention. Although firms can benefit from managing service expectations at the beginning of a relationship, we find that varying service in the long run is not optimal. Behavioral regularities explain the structure of optimal service policies and limit the value of responsive service. Loss aversion expands the range of optimal constant policies; however, if satisfying experiences are more salient, then firms should constantly vary service levels. Loyal or high-margin customers need not warrant better service; those who anchor less on past service experiences do—provided that retention is improved by better past experiences. The effect of customer memory on service levels is determined by whether habituation or rather goodwill drives defection decisions. This paper was accepted by Christian Terwiesch, operations management.
Gender Differences in Willingness to Guess
Authors: Baldiga Katherine 
Published: October 2013

We present the results of an experiment that explores whether women are less willing than men to guess on multiple-choice tests. Our test consists of practice questions from SAT II history tests; we vary whether a penalty is imposed for a wrong answer and the salience of the evaluative nature of the task. We find that when no penalty is assessed for a wrong answer, all test takers answer every question. But, when there is a penalty for wrong answers, women answer significantly fewer questions than men. We see no differences in knowledge of the material or confidence in the test takers, and differences in risk preferences explain less than half of the observed gap. Making the evaluative aspect of the test more salient does not impact the gender gap. We show that, conditional on their knowledge of the material, test takers who skip questions do significantly worse on our test. Data, as supplemental material, are available at http://dx.doi.org/10.1287/mnsc.2013.1776 This paper was accepted by Uri Gneezy, behavioral economics.
Editing I Will Not Hope
Authors: Macdonald Anna 
Published: October 2013

Abstract
This article discusses I Will Not Hope, a Screendance made in 2013, which involved a group of people trying to catch falling leaves in autumn. It is the last in a trilogy of Screendance works, by the author, that explore the tension between predictability, stillness and death, and contingency, movement and life. The analysis focuses, on the significance of I Will Not Hope’s editing, specifically the tension, referred to by film theorist Doane, between the edit as the creator of narrative predictability, and the edit as the creator of stillness, the creator of endings. In it I suggest that I Will Not Hope offers a connection between the ontological status of film, with its combination of contingency and structure embodied in the edit, and the relationship of these elements within the experience of hope.
The Right to Silence
Authors: Gray Anthony 
Published: October 2013

In recent years, we have seen continued erosion of an individual’s right to silence. The most recent attempts in the author’s home country, Australia, include a current proposal to adopt the United Kingdom approach, and allow inferences to be drawn from a failure to answer questions at an early stage of investigation, in circumstances where later the person does provide an explanation. An attempt to protect the right to silence in Australia at constitutional level is challenging, because Australia is one of the few Western nations that has not seen fit to enact an express bill of rights. This article will consider whether arguments might be made that, at least in some contexts, infringement of the right to silence is, nevertheless, contrary to the requirements of the Australian Constitution.
Courts in other countries around the world have also recognized the right to silence in some circumstances where legislatures have attempted to limit it, and these will be considered in the Australian context, acknowledging appropriate contextual differences. Many countries are faced with the difficulty of reconciling fundamental due process principles with the need for effective investigatory powers sufficient to deal with evolving criminal threats. It will be instructive to consider how a successful balance has been accommodated in a range of jurisdictions. It is believed that the law of the author’s home country could be greatly enriched by engaging with North American and European case law, as this article will seek to demonstrate. The article is considered to be of interest to those outside of Australia, to understand the difficulties in protecting fundamental human rights when an express bill of rights does not exist in the relevant country, and to consider how other ways may be found to protect such rights. In this way, this article will use Australia as the example of a country without an express bill of rights, and will consider how, in that context, fundamental human rights can practically be protected by the courts. The conclusions are considered relevant to a range of nations. Specific examples include Singapore and Malaysia, and to a lesser extent India, as will be explained.
A Large-Scale Behavioral Screen to Identify Neurons Controlling Motor Programs in the Drosophila Brain
Authors: Flood Thomas F , Gorczyca Michael , White Benjamin H , Ito Kei , Yoshihara Motojiro 
Published: October 2013

Abstract
Drosophila is increasingly used for understanding the neural basis of behavior through genetically targeted manipulation of specific neurons. The primary approach in this regard has relied on the suppression of neuronal activity. Here, we report the results of a novel approach to find and characterize neural circuits by expressing neuronal activators to stimulate subsets of neurons to induce behavior. Classical electrophysiological studies demonstrated that stimulation of command neurons could activate neural circuits to trigger fixed action patterns. Our method was designed to find such command neurons for diverse behaviors by screening flies in which random subsets of brain cells were activated. We took advantage of the large collection of Gal4 lines from the NP project and crossed 835 Gal4 strains with relatively limited Gal4 expression in the brain to flies carrying a UAS transgene encoding TRPM8, a cold-sensitive ion channel. Low temperatures opened the TRPM8 channel in Gal4-expressing cells, leading to their excitation, and in many cases induced overt behavioral changes in adult flies. Paralysis was reproducibly observed in the progeny of crosses with 84 lines, whereas more specific behaviors were induced with 24 other lines. Stimulation performed using the heat-activated channel, TrpA1, resulted in clearer and more robust behaviors, including flight, feeding, and egg-laying. Through follow-up studies starting from this screen, we expect to find key components of the neural circuits underlying specific behaviors, thus providing a new avenue for their functional analysis.
Estimating Soybean Genetic Gain for Yield in the Northern United States—Influence of Cropping History
Authors: Fox Carolyn M. , Cary Troy R. , Colgrove Alison L. , Nafziger Emerson D. , Haudenshield James S. , Hartman Glen L. , Specht James E. , Diers Brian W. 
Published: October 2013

ABSTRACTMean on‐farm U.S. soybean [Glycine max (L.) Merr.] yield increased at a rate of 23.4 kg ha−1 yr−1 between 1924 and 2010 due to a combination of genetic improvements, agronomic technologies, and climatic changes. To estimate annual rates of genetic yield gain in three northern U.S. soybean maturity groups (MGs) and determine if these estimates are influenced by cropping history, 45 MG II, 40 MG III, and 45 MG IV cultivars released between 1923 and 2008 were evaluated in split‐plot trials conducted in Illinois in 2010 where the main plot prior cropping treatments were either 11 yr of continuous corn (Zea mays L.) or 11 yr of a soybean–corn rotation. The experiment‐wide genetic yield gain estimate was 22.8 kg ha−1 yr−1 and, after covariate adjustment of yields for maturity, the estimate was 19.8 kg ha−1 yr−1. These estimates show that soybean genetic yield potential has been a large contributor to the rate of on‐farm yield improvement. The rate of yield gain estimates were not significantly different (P = 0.38) between the two cropping history treatments on an experiment‐wide basis or at the MG III and MG IV individual locations but were significantly different at the MG II locations, where yield gain for soybean following continuous corn was significantly greater compared with the soybean–corn rotation treatment. Modern cultivars were not observed to be able to close the yield gap between the two cropping history treatments used in this experiment.
Mini Core Collection as a Resource to Identify New Sources of Variation
Authors: Upadhyaya H.D. , Dronavalli N. , Dwivedi S.L. , Kashiwagi J. , Krishnamurthy L. , Pande S. , Sharma H.C. , Vadez V. , Singh S. , Varshney R.K. , Gowda C.L.L. 
Published: October 2013

ABSTRACTIn chickpea, bottlenecks associated with its domestication and low use of germplasm in improvement programs have resulted in a narrow genetic base and its vulnerability to abiotic and biotic stresses. The core and mini core collections, representing diversity in the entire collection, have been advocated for enhanced utilization of germplasm in crop improvement. A chickpea mini core (211 accessions) was evaluated for agronomic traits from 2000 and 2001 to 2003 and 2004 in post‐rainy seasons under irrigated and non‐irrigated conditions. The published information on the response of chickpea mini core accessions to stress revealed that 40 accessions had resistance to abiotic stress, 31 to biotic stress, and 24 had no resistance to either of the stresses. The abiotic and biotic stress resistant groups had six accessions in common. The mini core collection accessions were also a part of composite collection accessions in chickpea, which was genotyped using 48 simple sequence repeats (SSRs; BMC Plant Biol. 8:106, 2008). The agronomic evaluation, stress response, and molecular profiling data on 93 accessions, including four controls, were used to identify genetically diverse germplasm with agronomically beneficial traits. A number of genetically diverse accessions possessing agronomically beneficial traits, such as ICC 440, 637, 1098, 3325, 3362, 4872, 7441, 8621, 9586, 10399, 12307, 14402, 15680, and 15686, which meet breeders’ needs, have been identified for use in breeding and genetics to map genomic regions associated with beneficial traits and as source materials for developing high yielding and widely adapted chickpea cultivars with multiple resistance to abiotic and biotic stress.
Herbaceous periwinkle, Vinca herbacea Waldst. et Kit. 1799 (Apocynaceae), a new species of the Croatian flora
Authors: Csiky János , Purger Dragica 
Published: October 2013

Abstract
- Populations of herbaceous periwinkle, Vinca herbacea Waldst. et Kit., were found on April 2007 on Bansko Hill (Baranja, Croatia), which lies on the south-western edge of the range of this Pontic-Pannonian species. Since V. herbacea was included neither in the handbooks for plant identification nor in the current Croatian Flora Database, a new key for the determination of Vinca L. species of Croatia is presented herein. The herbaceous periwinkle should be treated as a critically endangered (CR) species in Croatia, considering the low number of individuals and the small extent of its occurrence in extremely rare habitats at the margin of its distribution. New recordings of some very rare or »data deficient « (DD) taxa of Croatia are also presented here: Scorzonera hispanica L. and Inula germanica L.
Three new species of Cymbella (Bacillariophyta) from high altitude lakes, China
Authors: Hu Zhujun , Li Yanling , Metzeltin Ditmar 
Published: October 2013

Abstract
- This paper describes three new Cymbella species from high altitude lakes of Hengduan Mountains region, southwest China. Cymbella heihainensis Li et Gong nov. spec. is similar to C. modicepunctata Krammer, C. asiatica Metzeltin, Lange-Bertalot et Li, Y., but differs from them in valve size, stigmata, raphe ending and also striae number. Cymbella shudunensis Li et Metzeltin nov. spec. is related to C. terrafuegiana, but differs in wider valve size, larger central area and coarser puncta. C. shudunensis differs from C. proxima Reimer in Patrick et Reimer group in reverse lateral raphes at the proximal endings, and distinguished from C.cistula (Ehrenberg) O.Kirchner group in the absent central area on dorsal side. Cymbella xingyunnensis Li and Gong sp. nov. resembles the group around C. proxima, and the most similar taxon is C. sinensis Metzeltn et Krammer, which can be distinguished by its lack of stigmata.
Lichenized fungi of a chestnut grove in Livari (Rumija, Montenegro)
Authors: Mayrhofer Helmut , Drescher Anton , Stešević Danijela , Bilovitz Peter O. 
Published: October 2013

Abstract
- Sixty taxa (59 species and 1 variety) of lichenized fungi are reported from a chestnut grove in Livari. The majority of them (55 species and 1 variety) occurred on Castanea sativa. The recently described Xylographa soralifera is new to the Balkan Peninsula. The lichenicolous fungus Monodictys epilepraria growing on Lepraria rigidula is new to Montenegro. The lichen mycota is compared with similar localities in Italy and Switzerland. The species composition in Livari is most similar to the Montieri site in Tuscany.
Leaf and stem anatomy in eight Hypericum species (Clusiaceae)
Authors: Perrone Rosaria , Rosa Paolode , Castro Olgade , Colombo Paolo 
Published: October 2013

Abstract
- Foliar micromorphology, epicuticular wax morphology and anatomical features of leaves and stem, particularly secondary xylem, were examined with light microscopy, general and histochemical staining and scanning electron microscopy in eight Hypericum species. Outer tegument tissue and type of secondary xylem are determining characteristics. Secondary xylem is ring-porous in H. perforatum, H. perfoliatum, H. tetrapterum, H. triquetrifolium, H. androsaemum and H. hircinum. In H. aegypticum and H. pubescens xylem is diffuse-porous, which is considered to be a more primitive type. These characteristics may be considered an additional criterion for species identification.
Cryoseston of the Pirin Mountains, Bulgaria
Authors: Cepák Vladislav , Lukavský Jaromír 
Published: October 2013

Abstract
- In the cryoseston community of the Pirin Mountains, 18 species were determined. Chlorophyta: Chlamydomonas nivalis (predominant), Chloromonas brevispina, Chloromonas rostafinski, Chlainomonas rubra (new genus and species for Bulgaria, documented in Europe for only the second time), Cystococcus nivicolus and Stichococcus nivalis. Bacillariophyceae: Aulacoseira granulata var. angustissima, Hantzchia amphioxys, cf. Surirella. Fungi: cf. Chytridium chlamydococcii. Deuteromycetes: Selenotila nivalis, Chionaster nivalis, and saprophytic fungae cf. Myzocytium, Rhodosporidium toruloides, Alternaria sp. and cf. Cladosporium, in pollen grains. Bacteria: Leptothrix ochracea. Ciliata: Vorticella campanula. The composition of cryoseston in the Pirin Mountains is characteristic for high mountains where Chlamydomonas nivalis predominates.
Enhancement of Supercritical Fluid Extraction in Membrane Cleaning Process by Addition of Organic Solvents
Authors: Krzysztoforski Jan , Krasiński Andrzej , Henczka Marek , Piątkiewicz Wojciech 
Published: October 2013

Abstract
In this study, the process of membrane cleaning by supercritical fluid extraction was investigated. Polypropylene microfiltration membranes, contaminated with oils, were treated in a batch process with a supercritical fluid (SCF). As extractant, pure supercritical carbon dioxide or supercritical carbon dioxide with admixtures of methanol, ethanol and isopropanol were used. Single-stage and multi-stage extraction was carried out and process efficiency was determined. The obtained results showed that addition of organic solvents significantly enhances the cleaning performance, which increases with increase of organic solvent concentration and decreases with increasing temperature. All three solvents showed a comparable effect of efficiency enhancement. The results confirmed that supercritical fluid extraction can be applied for polypropylene membrane cleaning.
Lower-Limb Power cannot be Estimated Accurately from Vertical Jump Tests
Authors: Tessier Jean-François , Basset Fabien-A , Simoneau Martin , Teasdale Normand 
Published: October 2013

Abstract
The countermovement jump test is often adopted to monitor lower-limb power of an individual. Despite several studies on the validity of this test, there is still a need to determine the minimal difference needed to be confident that a difference in power between two individuals is present or that a true change in the performance of an individual has occurred. In this study, power was measured from ground reaction forces and compared to that obtained from predictive equations for two groups of subjects (67 trained and 20 highly trained individuals). The height of each jump was determined with kinematic techniques. The main outcome is a large discrepancy between power calculated from ground reaction forces and that calculated from predictive equations. For the trained group, the R-square value between power and predicted power was 0.53 and the minimal difference to consider that two individuals were different was 821.7 W. For the highly trained individuals, a much larger R-square value was obtained (0.94). Despite this, the minimal difference to consider that two individuals were different was still large (689.3 W). The large minimal differences obtained raise serious concerns about using countermovement jumps for appraisal and monitoring of lower-limb power of an individual.