bluuebunny/crossref_metadata_2025_split huggingface dataset:
4D Printing: Design and Fabrication of 3D Shell Structures With Curved Surfaces Using Controlled Self-Folding
Authors: Deng Dongping , Chen Yong 
Published: September 2015

Self-folding structures such as origami-based structures have been studied by artists, mathematicians and engineers. New applications are emerging in fields such as biomedical and electronics. Self-folding structures can potentially extend three-dimensional (3D) printing into four-dimensional (4D) printing by intelligently designed material distribution in order to achieve controlled shape deformation over time. Traditionally, self-folding structures are folded along pre-defined hinges such that neighboring facets can transform their shapes. In this study, we present a new design and fabrication approach of self-folding structures with no foldable hinges. A significant benefit is its capability in fabricating shapes with smooth curved surfaces.
Our self-folding method is based on a thermally responsive mechanism, where a thermal responsive film is used as the active material while another polymer material coated on the film is used as the constraining material. When the structure is heated, the two sides of the film will shrink differently due to the constraining material. Consequently the structure will fold. By changing the constraining patterns and coated material properties, the film can be self-folded into different shapes. Three types of folding features are presented in our study. Based on them, an unfolding algorithm is presented for a given shell structure with curved surfaces. Theoretical analysis and experimental tests are presented to demonstrate the capability of the self-folding method. Its limitation and future work are also discussed.
Importance of Feature Sequencing in Incremental Forming
Authors: Lingam Rakesh , Harikrishnan C. L. , Kishan I. V. M. , Reddy N. Venkata 
Published: September 2015

Incremental Sheet Forming (ISF) is a flexible forming process suitable for low volume production of sheet metal components. Single Point Incremental Forming (SPIF), which has only one tool forming the geometry, is the simplest variant of incremental forming. Bending of sheet between the component opening and the fixed boundary is unavoidable in SPIF due to the absence of support/backup. Double Sided Incremental Forming (DSIF) has two tools which can be used interchangeably for forming and providing local support. The accuracy of parts formed using DSIF is superior to those formed using SPIF as the unwanted bending is substantially reduced by providing local support. In addition DSIF is capable of forming components with features on both sides of the initial plane of sheet and convex and concave features without additional setup.
In ISF, as the deformation progresses, the intended geometry slowly develops, this increases the stiffness of the sheet. While forming multiple features, the forming sequence greatly affects the way stiffness builds-up, which further affects the geometry of formed components. In the present work, an experimental investigation is carried out to demonstrate the affect of forming sequence on the geometries and accuracy of formed component. Results presented show that the feature sequencing greatly affects the geometry and accuracy of formed components.
Adaptive Robot Control as a Service in Cloud Manufacturing
Authors: Adamson Göran , Wang Lihui , Holm Magnus , Moore Philip 
Published: September 2015

The interest for implementing the concept of Manufacturing-as-a-Service is increasing as concepts for letting the manufacturing shop-floor domain take advantage of the cloud appear. Combining technologies such as Internet of Things, Cloud Computing, Semantic Web, virtualisation and service-oriented technologies with advanced manufacturing models, information and communication technologies, Cloud Manufacturing is emerging as a new manufacturing paradigm. The ideas of on-demand, scalable and pay-for-usage resource-sharing in this concept will move manufacturing towards distributed and collaborative missions in volatile partnerships. This will require a control approach for distributed planning and execution of cooperating manufacturing activities. Without control based on both global and local environmental conditions, the advantages of Cloud Manufacturing will not be fulfilled.
By utilising smart and distributable decision modules such as event-driven Function Blocks, run-time manufacturing operations in a distributed environment may be adjusted to prevailing manufacturing conditions. Packaged in a cloud service for manufacturing equipment control, they will satisfy the control needs. By combining different resource types, such as hard, soft and capability resources, the cloud service Robot Control-as-a-Service can be realised.
This paper describes the functional perspective and enabling technologies for a distributed control approach for robotic assembly tasks in Cloud Manufacturing.
Draft Genome Sequences of Six Nontypeable Haemophilus influenzae Strains That Establish Bacteremia in the Infant Rat Model of Invasive Disease
Authors: VanWagoner Timothy M. , Morton Daniel J. , Seale Thomas W. , Mussa Huda J. , Cole Brett K. , Whitby Paul W. , Stull Terrence L. 
Published: September 2015

ABSTRACT

Haemophilus influenzae
is an important cause of invasive disease. The infant rat is the accepted model of invasive
H. influenzae
disease. Here, we report the genome sequences of six nontypeable
H. influenzae
strains that establish bacteremia in the infant rat.
Avian Polyomavirus Genome Sequences Recovered from Parrots in Captive Breeding Facilities in Poland
Authors: Dayaram Anisha , Piasecki Tomasz , Chrząstek Klaudia , White Robyn , Julian Laurel , van Bysterveldt Katherine , Varsani Arvind 
Published: September 2015

ABSTRACT

Eight genomes of avian polyomaviruses (APVs) were recovered and sequenced from deceased
Psittacula eupatria
,
Psittacula krameri
, and
Melopsittacus undulatus
from various breeding facilities in Poland. Of these APV-positive samples, six had previously tested positive for beak and feather disease virus (BFDV) and/or parrot hepatitis B virus (PHBV).
First Draft Genome Sequence of Balamuthia mandrillaris, the Causative Agent of Amoebic Encephalitis
Authors: Detering H. , Aebischer T. , Dabrowski P. W. , Radonić A. , Nitsche A. , Renard B. Y. , Kiderlen A. F. 
Published: September 2015

ABSTRACT

The free-living amoeba
Balamuthia mandrillaris
is a rare but highly lethal agent of amoebic encephalitis in humans and many other mammalian species. Here, we announce the first draft genome sequence of the original 1990 isolate cultured from the brain of a deceased mandrill baboon.
Complete Genome and Plasmid Sequences of Three Canadian Strains of Salmonella enterica subsp.
enterica
Serovar Enteritidis Belonging to Phage Types 8, 13, and 13a
Authors: Rehman Muhammad Attiq , Labbé Geneviève , Ziebell Kim , Johnson Roger P. , Nash John H. E. 
Published: September 2015

ABSTRACT

Salmonella enterica
subsp.
enterica
serovar Enteritidis is a prominent cause of human salmonellosis frequently linked to poultry products. In Canada,
S
. Enteritidis phage types 8, 13, and 13a predominate among both clinical and poultry isolates. Here, we report the complete genome and plasmid sequences of poultry isolates of these three phage types.
Draft Genome Sequence of Methicillin-Resistant Clinical Staphylococcus aureus Isolate 51S (Sequence Type 291)
Authors: Marasa Bernard S. , Khan Saeed , Iram Saira , Sung Kidon , Xu Joshua 
Published: September 2015

ABSTRACT

We report the draft genome sequence of a methicillin-resistant clinical
Staphylococcus aureus
isolate with a novel
spa
type and sequence type (ST291), isolated from a renal failure patient in Rawalpindi, Pakistan.
Draft Genome Sequence of the Gram-Positive Thermophilic Iron Reducer Thermincola ferriacetica Strain Z-0001
T
Authors: Lusk Bradley G. , Badalamenti Jonathan P. , Parameswaran Prathap , Bond Daniel R. , Torres Cesar I. 
Published: September 2015

ABSTRACT

A 3.19-Mbp draft genome of the Gram-positive thermophilic iron-reducing
Firmicutes
isolate from the
Peptococcaceae
family,
Thermincola ferriacetica
Z-0001, was assembled at ~100× coverage from 100-bp paired-end Illumina reads. The draft genome contains 3,274 predicted genes (3,187 protein coding genes) and putative multiheme
c
-type cytochromes.
Complete Genome Sequence of Bifidobacterium actinocoloniiforme Type Strain DSM 22766
T
, Isolated from Bumblebee Digestive Tracts
Authors: Chen Xiaohan , E Zhiguo , Gu Donglu , Lv Longxian , Li Yudong 
Published: September 2015

ABSTRACT

Bifidobacteria are one of the most important beneficial bacteria in the gut of mammals and insects. We sequenced the genome of
B. actinocoloniiforme
DSM 22766, which was isolated from the digestive tracts of bumblebees. The genome contains 1,548 protein-coding genes, 49 RNAs and two CRISPR repeats.
Draft Genome Sequence of Purine-Degrading
Gottschalkia purinilyticum
(Formerly Clostridium purinilyticum) WA1 (DSM 1384)
Authors: Poehlein Anja , Bengelsdorf Frank R. , Schiel-Bengelsdorf Bettina , Daniel Rolf , Dürre Peter 
Published: September 2015

ABSTRACT

Here, we report the draft genome sequence of
Gottschalkia purinilyticum
(formerly
Clostridium purinilyticum
) WA1, an anaerobic bacterium specialized on degradation of purines (including adenine) and glycine, which uses the selenoprotein glycine reductase for substrate degradation. The genome consists of a single chromosome (3.40 Mb).
Draft Genome Sequence of Methicillin-Sensitive Staphylococcus aureus ATCC 29213
Authors: Soni Isha , Chakrapani Harinath , Chopra Sidharth 
Published: September 2015

ABSTRACT

Staphylococcus aureus
subsp.
aureus
ATCC 29213 is one of the most commonly used strains in drug discovery research and for quality control. We report the completed draft genome sequence for the strain.
Draft Genome Sequence of Roseovarius tolerans EL-164, a Producer of
N
-Acylated Alanine Methyl Esters and
N
-Acylhomoserine Lactones
Authors: Voget Sonja , Bruns Hilke , Wagner-Döbler Irene , Schulz Stefan , Daniel Rolf 
Published: September 2015

ABSTRACT

Roseovarius tolerans
EL-164 is a member of the
Roseobacter
clade, a group of marine bacteria within the
Alphaproteobacteria
. It produces different
N
-acylhomoserine lactone (AHL) autoinducers as well as five AHL-related but functionally different compounds, the
N
-acylated alanine methyl esters. The size of the draft genome is 3,749,755 bp.
Draft Genome Sequences of Two Commensal Enterococcus cecorum Strains Isolated from Chickens in Belgium
Authors: Dolka Beata , Boyen Filip , Butaye Patrick , Heidemann Olsen Rikke , Naundrup Thøfner Ida Cecilie , Christensen Jens Peter 
Published: September 2015

ABSTRACT

Here, we report the draft genome sequences of two commensal
Enterococcus cecorum
strains (1710s23 and 1711s24), cultivated from the ceca of healthy laying hens originating from different farms in Belgium.
Exercise for osteoarthritis of the knee: a Cochrane systematic review
Authors: Fransen Marlene , McConnell Sara , Harmer Alison R , Van der Esch Martin , Simic Milena , Bennell Kim L 
Published: September 2015

ObjectiveTo determine whether land-based therapeutic exercise is beneficial for people with knee osteoarthritis (OA) in terms of reduced joint pain or improved physical function and quality of life.MethodsFive electronic databases were searched, up until May 2013. Randomised clinical trials comparing some form of land-based therapeutic exercise with a non-exercise control were selected. Three teams of two review authors independently extracted data and assessed risk of bias for each study. Standardised mean differences immediately after treatment and 2–6 months after cessation of formal treatment were separately pooled using a random effects model.ResultsIn total, 54 studies were identified. Overall, 19 (35%) studies reported adequate random sequence generation, allocation concealment and adequately accounted for incomplete outcome data. However, research results may be vulnerable to selection, attrition and detection bias. Pooled results from 44 trials indicated that exercise significantly reduced pain (12 points/100; 95% CI 10 to 15) and improved physical function (10 points/100; 95% CI 8 to 13) to a moderate degree immediately after treatment, while evidence from 13 studies revealed that exercise significantly improved quality of life immediately after treatment with small effect (4 points/100; 95% CI 2 to 5). In addition, 12 studies provided 2-month to 6-month post-treatment sustainability data which showed significantly reduced knee pain (6 points/100; 95% CI 3 to 9) and 10 studies which showed improved physical function (3 points/100; 95% CI 1 to 5).ConclusionsAmong people with knee osteoarthritis, land-based therapeutic exercise provides short-term benefit that is sustained for at least 2–6 months after cessation of formal treatment.
Guideline-based decision support has a small, non-sustained effect on transthoracic echocardiography ordering frequency
Authors: Boggan Joel C , Schulteis Ryan D , Donahue Mark , Simel David L 
Published: September 2015

BackgroundGuidance for appropriate utilisation of transthoracic echocardiograms (TTEs) can be incorporated into ordering prompts, potentially affecting the number of requests.MethodsWe incorporated data from the 2011 Appropriate Use Criteria for Echocardiography, the 2010 National Institute for Clinical Excellence Guideline on Chronic Heart Failure, and American College of Cardiology Choosing Wisely list on TTE use for dyspnoea, oedema and valvular disease into electronic ordering systems at Durham Veterans Affairs Medical Center. Our primary outcome was TTE orders per month. Secondary outcomes included rates of outpatient TTE ordering per 100 visits and frequency of brain natriuretic peptide (BNP) ordering prior to TTE. Outcomes were measured for 20 months before and 12 months after the intervention.ResultsThe number of TTEs ordered did not decrease (338±32 TTEs/month prior vs 320±33 afterwards, p=0.12). Rates of outpatient TTE ordering decreased minimally post intervention (2.28 per 100 primary care/cardiology visits prior vs 1.99 afterwards, p<0.01). Effects on TTE ordering and ordering rate significantly interacted with time from intervention (p<0.02 for both), as the small initial effects waned after 6 months. The percentage of TTE orders with preceding BNP increased (36.5% prior vs 42.2% after for inpatients, p=0.01; 10.8% prior vs 14.5% after for outpatients, p<0.01).ConclusionsOrdering prompts for TTEs initially minimally reduced the number of TTEs ordered and increased BNP measurement at a single institution, but the effect on TTEs ordered was likely insignificant from a utilisation standpoint and decayed over time.
Increase of Clostridium perfringens in association with Eimeria in haemorrhagic enteritis in Japanese beef cattle
Authors: Kirino Y. , Tanida M. , Hasunuma H. , Kato T. , Irie T. , Horii Y. , Nonaka N. 
Published: September 2015

A coprological survey with detailed clinical observation of naturally occurring haemorrhagic enteritis (HE) cases was conducted to understand the pathophysiology of HE by clarifying the infection status of Eimeria and enteropathogenic bacteria in cattle. Faecal samples from 55 cases of HE and 26 clinically normal animals were collected, and a quantitative examination of Eimeria and potential enteropathogenic bacteria was performed. The number of Eimeria species oocysts per gram of faeces (OPG) exceeded 10,000 in 69.1 per cent of HE cases with a maximum of 1,452,500 OPG and Eimeria zuernii was found to be overwhelmingly dominant. A significant increase in faecal coliform count was observed in HE cases compared with clinically normal animals. Among the animals shedding >10,000 OPG, 42.9 per cent showed a remarkable increase in Clostridium perfringens abundance (>104 CFU/g) in the faeces. In the cases with C. perfringens detected, its abundance was positively correlated with Eimeria OPG and high C. perfringens abundance was always accompanied by high Eimeria OPG. E. zuernii is likely to play a crucial role in massive multiplication of C. perfringens in HE in cattle.
Multivalent Forms of the Notch Ligand DLL-1 Enhance Antitumor T-cell Immunity in Lung Cancer and Improve Efficacy of EGFR-Targeted Therapy
Authors: Biktasova Asel K. , Dudimah Duafalia F. , Uzhachenko Roman V. , Park Kyungho , Akhter Anwari , Arasada Rajeswara R. , Evans Jason V. , Novitskiy Sergey V. , Tchekneva Elena E. , Carbone David P. , Shanker Anil , Dikov Mikhail M. 
Published: September 2015

AbstractActivation of Notch signaling in hematopoietic cells by tumors contributes to immune escape. T-cell defects in tumors can be reversed by treating tumor-bearing mice with multivalent forms of the Notch receptor ligand DLL-1, but the immunologic correlates of this effect have not been elucidated. Here, we report mechanistic insights along with the efficacy of combinational treatments of multivalent DLL-1 with oncoprotein targeting drugs in preclinical mouse models of lung cancer. Systemic DLL-1 administration increased T-cell infiltration into tumors and elevated numbers of CD44+CD62L+CD8+ memory T cells while decreasing the number of regulatory T cells and limiting tumor vascularization. This treatment was associated with upregulation of Notch and its ligands in tumor-infiltrating T cells enhanced expression of T-bet and phosphorylation of Stat1/2. Adoptive transfer of T cells from DLL1-treated tumor-bearing immunocompetent hosts into tumor-bearing SCID-NOD immunocompromised mice attenuated tumor growth and extended tumor-free survival in the recipients. When combined with the EGFR-targeted drug erlotinib, DLL-1 significantly improved progression-free survival by inducing robust tumor-specific T-cell immunity. In tissue culture, DLL1 induced proliferation of human peripheral T cells, but lacked proliferative or clonogenic effects on lung cancer cells. Our findings offer preclinical mechanistic support for the development of multivalent DLL1 to stimulate antitumor immunity. Cancer Res; 75(22); 4728–41. ©2015 AACR.
Osteogenic Potential of Mesenchymal Stromal Cells Contributes to Primary Myelofibrosis
Authors: Martinaud Christophe , Desterke Christophe , Konopacki Johanna , Pieri Lisa , Torossian Frédéric , Golub Rachel , Schmutz Sandrine , Anginot Adrienne , Guerton Bernadette , Rochet Nathalie , Albanese Patricia , Henault Emilie , Pierre-Louis Olivier , Souraud Jean-Baptiste , de Revel Thierry , Dupriez Brigitte , Ianotto Jean-Christophe , Bourgeade Marie-Françoise , Vannucchi Alessandro M. , Lataillade Jean-Jacques , Le Bousse-Kerdilès Marie-Caroline 
Published: September 2015

Abstract
Primary myelofibrosis is a myeloproliferative neoplasm that is a precursor to myeloid leukemia. Dysmegakaryopoiesis and extramedullary hematopoiesis characterize primary myelofibrosis, which is also associated with bone marrow stromal alterations marked by fibrosis, neoangiogenesis, and osteomyelosclerosis. In particular, contributions to primary myelofibrosis from mesenchymal stromal cells (MSC) have been suggested by mouse studies, but evidence in humans remains lacking. In this study, we show that bone marrow MSCs from primary myelofibrosis patients exhibit unique molecular and functional abnormalities distinct from other myeloproliferative neoplasms and these abnormalities are maintained stably ex vivo in the absence of leukemic cells. Primary myelofibrosis-MSC overexpressed heparin-binding cytokines, including proinflammatory TGFβ1 and osteogenic BMP-2, as well as glycosaminoglycans such as heparan sulfate and chondroitin sulfate. Transcriptome and functional analyses revealed alterations in MSC differentiation characterized by an increased osteogenic potential and a TGFβ1 signaling signature. Accordingly, phospho-Smad2 levels were intrinsically increased in primary myelofibrosis-MSC along with enhanced expression of the master bone regulator RUNX2, while inhibition of the endogenous TGFβ1 receptor TGFβR1 impaired osteogenic differentiation in these MSCs. Taken together, our results define the source of a critical osteogenic function in primary myelofibrosis that supports its pathophysiology, suggesting that combined targeting of both the hematopoietic and stromal cell compartments in primary myelofibrosis patients may heighten therapeutic efficacy. Cancer Res; 75(22); 4753–65. ©2015 AACR.
Combined assessment of thrombotic and haemorrhagic risk in acute medical patients
Authors: Orlandini Francesco , Marchini Francesca , Marinaro Alessia , Bonacci Rosanna , Bonanni Paola , Corsini Francesca , Ceraudo Anna Maria , Pacetti Edoarda , Scuotri Lucia , Costabile Davide , Dentali Francesco , Regina Micaela La 
Published: September 2015

SummaryAcute medical patients have a high risk of venous thromboembolic events (VTE). Unfortunately, the fear of bleeding complications limits the use of antithrombotic prophylaxis in this setting. To stratify the VTE and haemorrhagic risk, two clinical scores (PADUA, IMPROVE) have recently been developed. However, it is not clear how many patients have a concomitant high VTE and haemorrhagic risk and what is the use of prophylaxis in this situation. To clarify these issues we performed a prospective cohort study enrolling consecutive patients admitted to internal medicine. Patients admitted to internal medicine (January to December 2013) were included. VTE and haemorrhagic risk were evaluated in all the included patients. Use and type of anti-thrombotic prophylaxis was recorded. A total of 1761 patients (mean age 77.6 years) were enrolled; 76.8 % (95 % CI 74.7–78.7) were at high VTE risk and 11.9 % (95 % CI 10.4–13.5) were at high haemorrhagic risk. Anti-thrombotic prophylaxis was used in 80.5 % of patients at high VTE risk and in 6.5 % at low VTE risk (p< 0.001), and in 16.6 % at high haemorrhagic risk and in 72.5 % at low haemorrhagic risk (p< 0.001). Prophylaxis was used in 20.4 % at both high VTE and haemorrhagic risk and in 88.9 % at high VTE risk but low haemor-rhagic risk. At multivariate-analysis, use of prophylaxis appeared highly influenced by the VTE risk (OR 68.2, 95 % CI 43.1 - 108.0). In conclusion, many patients admitted to internal medicine were at high risk of VTE. Since almost 90 % of them were at low haemorrhagic risk, pharmacological prophylaxis may be safely prescribed in most of these patients.Supplementary Material to this article is available online at www.thrombosis-online.com.
Macrophage Notch Ligand Delta-Like 4 Promotes Vein Graft Lesion Development
Authors: Koga Jun-ichiro , Nakano Toshiaki , Dahlman James E. , Figueiredo Jose-Luiz , Zhang Hengmin , Decano Julius , Khan Omar F. , Niida Tomiharu , Iwata Hiroshi , Aster Jon C. , Yagita Hideo , Anderson Daniel G. , Ozaki C. Keith , Aikawa Masanori 
Published: September 2015

Objective—
Despite its large clinical impact, the underlying mechanisms for vein graft failure remain obscure and no effective therapeutic solutions are available. We tested the hypothesis that Notch signaling promotes vein graft disease.

Approach and Results—

We used 2 biotherapeutics for Delta-like ligand 4 (Dll4), a Notch ligand: (1) blocking antibody and (2) macrophage- or endothelial cell (EC)–targeted small-interfering RNA. Dll4 antibody administration for 28 days inhibited vein graft lesion development in low-density lipoprotein (LDL) receptor-deficient (
Ldlr
−/−
) mice, and suppressed macrophage accumulation and macrophage expression of proinflammatory M1 genes. Dll4 antibody treatment for 7 days after grafting also reduced macrophage burden at day 28. Dll4 silencing via macrophage-targeted lipid nanoparticles reduced lesion development and macrophage accumulation, whereas EC-targeted Dll4 small-interfering RNA produced no effects. Gain-of-function and loss-of-function studies suggested in vitro that Dll4 induces proinflammatory molecules in macrophages. Macrophage Dll4 also stimulated smooth muscle cell proliferation and migration and suppressed their differentiation.

Conclusions—
These results suggest that macrophage Dll4 promotes lesion development in vein grafts via macrophage activation and crosstalk between macrophages and smooth muscle cells, supporting the Dll4–Notch axis as a novel therapeutic target.