bluuebunny/crossref_metadata_2025_split huggingface dataset:
A direct interaction between fascin and microtubules contributes to adhesion dynamics and cell migration
Authors: Villari Giulia , Jayo Asier , Zanet Jennifer , Fitch Briana , Serrels Bryan , Frame Margaret , Stramer Brian M. , Goult Benjamin T. , Parsons Maddy 
Published: November 2015

ABSTRACT
Fascin is an actin-binding and bundling protein that is highly upregulated in most epithelial cancers. Fascin promotes cell migration and adhesion dynamics in vitro and tumour cell metastasis in vivo. However, potential non-actin bundling roles for fascin remain unknown. Here, we show for the first time that fascin can directly interact with the microtubule cytoskeleton and that this does not depend upon fascin-actin bundling. Microtubule binding contributes to fascin-dependent control of focal adhesion dynamics and cell migration speed. We also show that fascin forms a complex with focal adhesion kinase (FAK, also known as PTK2) and Src, and that this signalling pathway lies downstream of fascin–microtubule association in the control of adhesion stability. These findings shed light on new non actin-dependent roles for fascin and might have implications for the design of therapies to target fascin in metastatic disease.
Development of Novel Reactions Induced by Coherent Molecular Vibrational Excitation and Direct Observation of Molecular Structural Change during “Thermal” Reactions
Authors: Iwakura Izumi , Yabushita Atsushi 
Published: November 2015

Abstract
Femtochemistry began from the observation of transition states (TSs) in gas-phase photoreactions. Later developments in visible ultrashort laser pulses enabled visualization of real-time changes in the molecular vibrational modes during photoreactions, including those in the liquid phase. However, TSs in thermal reactions could still not be studied, because the conventional femtosecond laser pulse cannot trigger chemical reactions in the electronic ground state. In the present work, a visible ultrashort laser pulse was used to cause an induced Raman process, whereby Raman active molecular vibrational modes were excited in the electronic ground states, which triggers the reaction induced by coherent molecular vibrational excitation in the electronic ground state just after photoexcitation. Using the “reaction by coherent molecular vibration”, we have successfully observed the TSs in a “thermal” reaction, thermal Claisen rearrangement.
Elucidation of Excitatory Neurotransmission and Membrane Protein Integration Mechanisms
Authors: Shimamoto Keiko 
Published: November 2015

Abstract
Membrane proteins, such as receptors, transporters, and enzymes, play various roles in the survival of organisms. Discovery and development of new bioactive molecules interacting with these proteins are indispensable for understanding the mechanisms of biological events. This account summarizes our efforts on (1) design and synthesis of glutamate transporter blockers to elucidate the mechanism of excitatory neurotransmission process and (2) identification of a novel glycolipid that is essential for membrane protein integration.
Research and evidence in education decision-making: A comparison of results from two pan-Canadian studies
Authors: Galway Gerald , Sheppard Bruce 
Published: November 2015

In this paper we compare the use of research and other evidence in the policy formation practices of two groups of education policy elites, situated in different contexts – provincial education ministries and school districts. Data are derived from two pan-Canadian studies: Galway (2006) and Sheppard, Galway, Brown & Wiens (2013). The findings show that policy decisions at the ministry level are informed primarily by political and pragmatic factors, personal and professional beliefs and staff advice. The role of external research is shown to be relatively marginal and confined to quantitative studies and performance assessments. Decision makers at the school district level are less attendant to political and pragmatic influences relying more on personal beliefs, values and experiential factors supplemented by the advice of professional staff and in-house research/indicators. Results from both studies demonstrate limited reliance on external data and university-based research – the latter ranking 15th of 20 influencing factors. Consistent with Beck’s (1994; 1997) risk theory, we theorize that education policy making in both contexts is influenced by both macro- and micro-level factors, where choice of policy evidence is mediated by personal considerations and political risk factors. This suggests a weak policy development paradigm that is, to a large extent, resistant to independent research-informed evidence.
Prospects of geothermal water
Use in cultivation of Spirulina
Authors: Godlewska Katarzyna , Tomaszewska Barbara , Michalak Izabela , Bujakowski Wiesław , Chojnacka Katarzyna 
Published: November 2015

Abstract
Spirulina has been studied due to its commercial importance as a source of essential amino acids, protein, vitamins, fatty acids etc. Most of the culture systems in use today are open ponds. The new approach proposed in this paper is to use the geothermal water as a medium for microalgae cultivation. Poland has beneficial conditions for wide geothermal use, as one of the environmentally friendly and sustainable renewable energy sources. In the planned research, geothermal water could be used to prepare microalgal culture medium, to heat greenhouses with bioreactors used for the growth of Spirulina, to dry the obtained biomass, as well as to heat the ground in foil tunnels. Using geothermal water gives the possibility to produce algae in open ponds covered with greenhouses and to cultivate plants during winter. The obtained algae can be used for the production of algal bio-products (e.g. homogenates), having the potential application in plant cultivation.
On Inferring Income Inequality Measures Using L-moments
Authors: Sreelakshmi N. , Asha G. , Muraleedharan Nair K. R. 
Published: November 2015

Abstract
L-moments are expectations of linear combinations of order statistics, their use in reliability analysis has been established. In the present paper we study L-moments in relation to income inequality measures. Models characterized by functional relationships between L-moments and income inequality measures are studied. Finally, we define the ordering based on L-moments and study its implications on other existing orderings.
Joseph of Nazareth in theProtevangelium of James
Authors: Glessner Justin M. 
Published: November 2015

AbstractThe tensions and gaps between Joseph’s canonical reception (in Matthew 1-2 and Luke 1-2) left him wide open for literary development. This essay considers the reception of Joseph in theProtevangelium of James(PJ) and examines the overlapping and intertwining ways in which interpretation and social context influence that reception. In contrast to that of Luke (Luke 1-2) and similar to that of Matthew (Matt 1-2), PJ’s infancy account is arguablyJoseph’stale. Joseph’s point-of-view characterization in PJ feasibly plays a key role in mediating collective memory and putative in-group identity, bound up with the processes of male self-fashioning. In particular, through its meditation on the outwardly perplexing circumstances of Joseph’s ‘not quite’ marriage to Mary and in its positioning of the ‘rodhandling’ priestly elite, PJ can be seen to have been instrumental in inspiring, or at least being conducive to, forms of masculine subjectivity at home within early Syrian ascetical circles.
In-vitro hemolysis and its financial impact using different blood collection systems
Authors: Cadamuro Janne , Fiedler Georg Martin , Mrazek Cornelia , Felder Thomas Klaus , Oberkofler Hannes , Kipman Ulrike , Haschke-Becher Elisabeth , Wiedemann Helmut 
Published: November 2015

Abstract

Background: Hemolytic specimens are among the most challenging preanalytical issues in laboratory diagnostics. The type of blood collection tube in use is claimed to influence in vitro hemolysis. We aimed to examine this hypothesis and estimate the respective financial impact, evaluating routine blood samples from the past 4 years.

Methods: A total of 47,820 hemolysis index (HI) values from five different time intervals (IV1–IV5) were compared against each other, representing the following tubes: IV1-Sarstedt Monovette; IV2-8 mL/16×100 mm Greiner BioOne (GBO) Vacuette; IV3/IV4-5 mL/16×100 mm GBO Vacuette; IV5-4.5 mL/13×75 mm GBO Vacuette. For estimation of the economic impact, material, personnel and analytical costs were calculated.

Results: HI mean values in time interval IV2 were significantly higher than in all other intervals, while mean values amongst all other intervals were comparable. The number of moderately and severely hemolyzed samples increased with incrementing vacuum. Overall comparable costs between intervals IV1 and IV5 were €11,370, €14,045, €12,710, €11,213 and €8138 per 10,000 samples, respectively.

Conclusions: Aspiration tubes and low vacuum tubes show comparable hemolysis rates. Increasing vacuum levels are associated with higher hemolysis rates. By decreasing in vitro hemolysis, financial savings up to €5907 per 10,000 samples could be gained.
Widening and clustering techniques allowing the use of monotone CFTP algorithm
Authors: Bounnite Mohamed Yasser , Nasroallah Abdelaziz 
Published: November 2015

Abstract
The standard Coupling From The Past (CFTP) algorithm is an interesting tool to sample from exact stationary distribution of a Markov chain. But it is very expensive in time consuming for large chains. There is a monotone version of CFTP, called MCFTP, that is less time consuming for monotone chains. In this work, we propose two techniques to get monotone chain allowing use of MCFTP: widening technique based on adding two fictitious states and clustering technique based on partitioning the state space in clusters. Usefulness and efficiency of our approaches are showed through a sample of Markov Chain Monte Carlo simulations.
Impacts of users’ antisocial behaviors in an ophthalmologic emergency department—a qualitative study
Authors: d'Aubarede Constance , Sarnin Philippe , Cornut Pierre‐Loïc , Touzet Sandrine , Duclos Antoine , Burillon Carole , Fassier Jean‐Baptiste 
Published: November 2015

Impacts of users’ antisocial behaviors in an ophthalmologic emergency department – a qualitative study: Constance d'Aubarede, et al. UMR T 9405 (Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail. Environnement: UMRESTTE), Université Claude Bernard Lyon 1, FranceBackgroundHealth‐care workers in emergency departments are frequently exposed to risk of antisocial behavior and violence (ABV) by users. Underreporting of ABV by health‐care professionals has been identified. In order to understand this phenomenon, we explored the experience of ABV in 30 health workers in an ophthalmology emergency department in the Rhône‐Alpes administrative region of France.MethodsA grounded theory qualitative approach was followed. Data were collected from field observations, 30 semistructured individual interviews, violence report forms, and 364 patient satisfaction questionnaires. Qualitative thematic content analysis of the interviews was performed with qualitative data analysis software.ResultsThird‐party antisocial behaviors and violence were an everyday occurrence, with varying levels of seriousness: impoliteness, vulgarity, nonrecognition, insults, verbal threats, and aggressive gestures. Healthcare workers adopted various strategies to adapt to such violence: proactive and reactive attitudes and avoidance. Several organizational factors concerning the political and economic context, hospital work organization, and health workers’ behavior were identified as potentially contributing to ABV. Excessive waiting times, lack of user information, and understaffing emerged as factors contributing to users'ABV.ConclusionsAntisocial behaviors by hospital users are underreported by professionals and under‐recognized. They appear to be like continuous occupational exposure leading to delayed adverse consequences either on workers’ health or motivation. However, violence in hospitals is not the result of only the action of users, and it may be related to work organization and workers’ own behaviors. Only a grounded analysis of the causes of violence in the local work context can uncover relevant solutions.
Sensores de fibra óptica FBG para el monitoreo de la salud estructural de los puentes
Authors: Navarro-Henríquez Francisco 
Published: November 2015

<p class="p1">El presente artículo forma parte de un estudio inicial realizado como parte del proyecto de investigación “eBridge 2.0: sistema integrado para el desempeño de puentes”. </p><p class="p1">Los sistemas con sensores de fibra óptica FBG (Fiber Bragg Grating) se han venido consolidando en el Monitoreo de la Salud Estructural de puentes, en Pruebas No Destructivas estáticas y dinámicas con mediciones de deformación, desplazamiento, deflexión, temperatura y vibraciones. En este trabajo se presenta una breve introducción a la tecnología y los fundamentos de los sensores de fibra óptica, su uso y las ventajas comparativas respecto a su contraparte tradicional. Como muestra práctica de la aplicación de sensores FBG, se describen sus características y se presentan gráficas de medición. Por último, se mencionan algunos aspectos clave que se deben tener en cuenta para su adecuado uso en el campo. </p>
LEMBAGA FATWA KEAGAMAAN DI INDONESIA (Telaah Atas Lembaga Majlis Tarjih dan Lajnah Bathsul Masail)
Authors: Nasih Ahmad Munjin 
Published: November 2015

Muhammadiyah and NU are two of the greatest Islamic Organizations in Indonesia which have colored the dynamic of nation religious life. Through both organisazion, there are many fatwas issued on which the each follower undertake their religious. If viewed from products, the fatwas were issued by Muhammadiyah and NU often indicate some difference. This reality can be understood because both organization have the different mecanism of legal istinbath. The fact that Muhammadiyah by Majlis Tarjih and NU by Bahtsul Masailnya have a difference approach so that fatwas issued by each organization difference as well. This paper will elaborate the dinamic of difference between Majelis Tarjih of Muhammadiyah and Bahtsul Masail of NU. Muhammadiyah dan NU adalah dua ormas Islam terbesar di Indonesia yang selama ini mampu mewarnai dinamika kehidupan beragama bangsa ini. Melalui keduanya telah lahir banyak produk hukum (baca: fatwa) yang dijadikan pegangan oleh masing-masing pengikutnya dalam menjalani kehidupan beragama. Dilihat dari sisi produk, selama ini fatwa yang dikeluarkan oleh Muhammadiyah dan NU seringkali menunjukkan perbedaannya. Hal ini sangat bisa dimaklumi mengingat bahwa dua organisasi ini mempunyai mekanisme yang berbeda dalam melakukan istinbath hukum. Kenyataan bahwa Muhammadiyah melalui Majlis Tarjih dan NU melalui Lembaga Bahtsul Masailnya memiliki pendekatan yang berbeda dalam melakukan istinbath hukum, karena itu tidak mengherankan jika fatwa yang dikelurkan juga berbeda. Tulisan ini akan menggambarkan dinamika perbedaan yang terjadi dalam Majelis Tarjih Muhammadiyah dan Lembaga Bahtsul Masail NU.
Tendinopathy: Evidence-Informed Physical Therapy Clinical Reasoning
Authors: Vicenzino Bill 
Published: November 2015

Patients presenting with pain at the tendon, which is associated with physical tasks and activities that specifically load that tendon, are at the center of this special issue. The current terminology for a symptomatic tendon presentation is tendinopathy, as this does not denote an underlying pathology, but rather signals that all is not well in the tendon. Tendinopathy is a prevalent and substantial problem, as it interferes with a person's capacity to lead a physically active and healthy life, which has a considerable flow-on effect on society in general. This issue deals with the contemporary physical therapy management of tendinopathy by providing a mix of evidence review and clinical expert opinion on commonly presenting tendinopathies of the lower and upper limbs. J Orthop Sports Phys Ther 2015;45(11):816–818. doi:10.2519/jospt.2015.0110
Guidelines and Pathways for Clinical Practice in Tendinopathy: Their Role and Development
Authors: Morrissey Dylan 
Published: November 2015

Tendinopathy has significant consequences for both the athletic population and, more importantly, those who exercise for health or engage in physical activity as part of their occupation. That we are now able to perform high-quality evidence syntheses based on robust primary evidence for a wide range of conditions and therapeutic approaches is a credit to the pioneers who have driven the evidence explosion, and an inspiration for those striving to emulate and build on their achievements. How do we take that evidence and apply it in the clinical setting to individual patients? How do we adjust our decision-making schema in response to the presented information and challenges? J Orthop Sports Phys Ther 2015;45(11):819–822. doi:10.2519/jospt.2015.0111
Should We Care About Tendon Structure? The Disconnect Between Structure and Symptoms in Tendinopathy
Authors: Ryan Michael , Bisset Leanne , Newsham-West Richard 
Published: November 2015

We can visualize tendons better than ever before. Medical imaging today provides increasingly higher-resolution images, enabling larger fields of view that allow clinicians and researchers to more precisely characterize tendon structure. Yet, does seeing a patient's tendon provide any meaningful benefit to our clinical reasoning, and will it make a difference to treatment outcomes? It is little surprise that concomitant with this imaging availability is a renewed debate over the relationship between the appearance of tendon structure and symptomology. Despite the advances in medical imaging, as well as the clinical and research interest in tendinopathy, there does not appear to be any greater clarity on reconciling a patient's clinical presentation with either baseline characterization of structural abnormalities or the time series of changes following selected interventions. It may be helpful, therefore, to take a step back and give renewed consideration to the anatomical and physiological role of tendon structure, and to consider this in the context of what we know about tendon pathology. J Orthop Sports Phys Ther 2015;45(11):823–825. doi:10.2519/jospt.2015.0112
Imaging of Tendinopathy: A Physician's Perspective
Authors: Bley Bradley , Abid Waqas 
Published: November 2015

Imaging plays an important role in the clinical evaluation of patients with musculoskeletal-related pain, but its utility for the management of tendinopathy is debatable. Findings on ultrasound and magnetic resonance imaging may not correlate with clinical symptoms, and it is not uncommon to find anatomical changes associated with tendinopathy in tendons of asymptomatic individuals. Likewise, patients with clinical symptoms of tendinopathy can present with normal imaging evaluation. The use of diagnostic and interventional ultrasound has significantly increased over the past decade in a bid for better treatments of tendinopathy. Despite the limitations of traditional imaging in the diagnosis and management of tendinopathy, interventional procedures that utilize ultrasound hold promise. J Orthop Sports Phys Ther 2015;45(11):826–828. doi:10.2519/jospt.2015.0113
Not All Tendons Are Created Equal: Implications for Differing Treatment Approaches
Authors: Michener Lori A. , Kulig Kornelia 
Published: November 2015

The majority of muscles have distinct tendinous attachments to bones; however, only a few tendons develop painful conditions. That simple observation prompts us to ask a few questions. Are there commonalities in morphology and pathology among the painful tendons? What contributes to the propensity for pathology in some, but not all, tendons? And, consequently, should all tendinopathies be managed equally? Two common tendinopathies are those affecting the Achilles and supraspinatus, which are presented in this special issue and serve as excellent models to discuss similarities and contrasts. J Orthop Sports Phys Ther 2015;45(11):829–832. doi:10.2519/jospt.2015.0114
Stress Fracture of the Sacrum
Authors: Hearn Darren W. , Humphrey David W. 
Published: November 2015

A physical therapist evaluated a 25-year-old male military trainee, who reported 1 week of left hip pain exacerbated by running and sitting cross-legged. At follow-up, the patient reported unchanged hip pain and new left knee pain. Due to potential for multifocal stress injuries outside the visual field of a single MRI, bone scan and single-photon emission computerized tomography were chosen as imaging modalities. Imaging revealed a nondisplaced lateral left-sided sacral stress fracture and left calcaneal stress fracture. J Orthop Sports Phys Ther 2015;45(11):965. doi:10.2519/jospt.2015.0411
Quantifying Eroded Sediment Volume during Drumlin Formation in Simcoe County
Authors: Englert Rebecca G. , Ingram Rebekah C. , Madronich Lauren I. , Maloney Katie M. , Moor Kira B. , Rooney Kendal C. , Mulligan Riley P.M. 
Published: November 2015

Drumlins, despite being well studied, are still incredibly enigmatic in terms of their formation processes. Theories on their origin vary widely, and the evidence presented in this study seeks to assist in this debate. To support an erosional theory for the formation of drumlins, large volumes of sediment would have undergone transport and deposition. The volume of sediment that would have eroded from part of the Peterborough Drumlin Field in Simcoe County was calculated using two methods in a GIS. The limitations of both methods and the geological composition of potential sediment sinks were analysed. The range of eroded sediment volume was calculated to be 3.5–8.3 km3, which could fill between 30.2% and 71.6% of the Lake Simcoe basin. The high volume of sediment that was estimated in this study will have future implications in the drumlin debate and for the feasibility of an erosional process of formation.
Delineation of Paleowind Direction from Dunes in Simcoe County, Ontario
Authors: To Kelly K. , Clements Kristin A. , De Thomasis Sara L. , Smolarz Alanna G. , van Beest Christine E.S. , Pollock Mark A. , Zuber Corina R. , Francis Nicolette D. , Mulligan Riley P.M. 
Published: November 2015

Dune fields that developed along paleolake shorelines in Ontario are a product of paleoenvironmental conditions, which developed as a result of glacially influenced geological processes. In Simcoe County, Ontario, many dune fields were created between 3 and 12 ka, when this area was covered by a series of lakes, bordered by thick sandy beaches. Coastal sediments of the glacial Lake Algonquin and the Nipissing phase of the upper Great Lakes were reworked primarily by paleowind activity and intense periodic storms once lake levels had decreased. This formed dunes, which are now common along the south-eastern coast of Georgian Bay in Simcoe County. Dunes that developed earlier (8–10 ka) have a different average orientation than dunes that developed later (3–5 ka). Various geomorphometric techniques are tested to construct a replicable methodology for determining paleowind direction. Through identification of parabolic dunes, azimuth angles were determined and used to infer the dominant paleowind directions. Dunes on the paleolake Algonquin plain commonly have a north-east to south-west orientation, whereas dunes associated with Nipissing phase shorelines formed via north-westerly winds. These data may suggest changing prevailing winds in the Great Lakes region during deglaciation.