bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive systematic review of health-related quality of life measures in short stature paediatric patients
Authors: Adedeji Adekunle , Witt Stefanie , Innig Florian , Quitmann Julia 
Published: July 2024

AbstractThis systematic review investigates Patient-reported Outcome Measures (PROMs) and Observed Reported Outcome Measures (ObsROMs) pertinent to assessing Health-Related Quality of Life (HRQoL) in short-stature paediatric patients, focusing on Achondroplasia (ACH), Growth Hormone Deficiency (GHD), Isolated Growth Hormone Deficiency (IGHD), and Small-for-Gestational-Age (SGA) diagnoses. Utilising rigorous selection criteria, 53 studies published from 1998 to 2023 were analysed, revealing a predominance of European-based research. Notably, the review elucidated the utilisation of disease-specific and generic HRQoL measures, showcasing the multifaceted nature of short-stature conditions and their impact across physical, emotional, and social domains. The Quality of Life in Short Stature Youth (QoLISSY), Paediatric Quality of Life Inventory (PedsQL), and KIDSCREEN emerged as frequently employed instruments, offering nuanced insights into HRQoL perceptions across diverse age demographics. Additionally, the review highlighted the adaptation of adult HRQoL measures for adolescent populations, signalling a need for age-appropriate assessment tools. Furthermore, integrating PROMs and ObsROMs in HRQoL assessment underscored a comprehensive approach, considering both subjective patient perspectives and observed outcomes. Future research directions encompass comprehensive search strategies, longitudinal studies with diverse populations, and the development of age-appropriate HRQoL assessment tools. In conclusion, this review emphasises the importance of comprehensive HRQoL assessment to address the diverse needs of short-stature paediatric patients effectively.
Mode division multiplexing reconstructive spectrometer with an all-fiber photonics lantern
Authors: Liang Junrui , Ye Jun , Ma Xiaoya , Lu Yao , Li Jun , Xu Jiangming , Chen Zilun , Leng Jinyong , Jiang Zongfu , Zhou Pu 
Published: July 2024

AbstractThis study presents a high-accuracy, all-fiber mode division multiplexing (MDM) reconstructive spectrometer (RS). The MDM was achieved by utilizing a custom-designed 3 × 1 mode-selective photonics lantern to launch distinct spatial modes into the multimode fiber (MMF). This facilitated the information transmission by increasing light scattering processes, thereby encoding the optical spectra more comprehensively into speckle patterns. Spectral resolution of 2 pm and the recovery of 2000 spectral channels were accomplished. Compared to methods employing single-mode excitation and two-mode excitation, the three-mode excitation method reduced the recovered error by 88% and 50% respectively. A resolution enhancement approach based on alternating mode modulation was proposed, reaching the MMF limit for the 3 dB bandwidth of the spectral correlation function. The proof-of-concept study can be further extended to encompass diverse programmable mode excitations. It is not only succinct and highly efficient but also well-suited for a variety of high-accuracy, high-resolution spectral measurement scenarios.
Graphical Abstract
Case series of Li-Fraumeni syndrome: carcinogenic mechanisms in breast cancer with TP53 pathogenic variant carriers
Authors: Hosonaga Mari , Habano Eri , Arakawa Hiromi , Kaneko Keika , Nakajima Takeshi , Hayashi Naomi , Fukada Ippei , Nakamura Akira , Haruyama Yurie , Maeda Tetsuyo , Inari Hitoshi , Kobayashi Takayuki , Nakashima Eri , Ueno Takayuki , Takano Toshimi , Takahashi Shunji , Ohno Shinji , Ueki Arisa 
Published: July 2024

Abstract
Background
Li-Fraumeni syndrome (LFS), a hereditary condition attributed to TP53 pathogenic variants,(PV), is associated with high risks for various malignant tumors, including breast cancer. Notably, individuals harboring TP53 PVs are more likely (67–83%) to develop HER2 + breast cancer than noncarriers (16–25%). In this retrospective study, we evaluated the associations between TP53 variants and breast cancer phenotype.

Methods
We conducted a retrospective review of the medical records of patients with LFS treated at a single institution and reviewed the literature on TP53 functions and the mechanisms underlying HER2 + breast cancer development in LFS.

Results
We analyzed data for 10 patients with LFS from 8 families. The median age at the onset of the first tumor was 35.5 years. Only case 2 met the classic criteria; this patient harbored a nonsense variant, whereas the other patients carried missense variants. We observed that 9 of 10 patients developed breast cancer. Immunohistochemical analyses revealed that 40% of breast cancers in patients with LFS were HR − /HER2 + . The median age at the onset of breast cancer was slightly younger in HR − /HER2 + tumors than in HR + /HER2 −  tumors (31 years and 35.5 years, respectively).

Conclusions
The occurrence of HER2 + breast cancer subtype was 40% in our LFS case series, which is greater than that in the general population (16–25%). Some TP53 PVs may facilitate HER2-derived oncogenesis in breast cancer. However, further studies with larger sample sizes are warranted to clarify the oncogenic mechanisms underlying each subtype of breast cancer in TP53 PV carriers.
Development of a nomogram to predict recurrence scores obtained using Oncotype DX in Japanese patients with breast cancer
Authors: Shibata Akio , Tamura Nobuko , Kinowaki Keiichi , Nishikawa Aya , Tanaka Kiyo , Kobayashi Yoko , Ogura Takuya , Tanabe Yuko , Kawabata Hidetaka 
Published: July 2024

Abstract
Background
Chemotherapy is crucial for hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative breast cancer, and its survival benefits may outweigh adverse events. Oncotype DX (ODX) assesses this balance; however, it is expensive. Using nomograms to identify cases requiring ODX may be economically beneficial. We aimed to identify clinicopathological variables that correlated with the recurrence score (RS) and develop a nomogram that predicted the RS.

Methods
We included 457 patients with estrogen receptor-positive, HER2-negative breast cancer with metastases in fewer than four axillary lymph nodes who underwent surgery and ODX at our hospital between 2007 and 2023. We developed nomograms and internally validated them in 310 patients who underwent surgery between 2007 and 2021 and validated the model’s performance in 147 patients who underwent surgery between 2022 and 2023.

Results
Logistic regression analysis revealed that progesterone receptor (PgR) level, histological grade (HG), and Ki67 index independently predicted the RS. A nomogram was developed using these variables to predict the RS (area under the curve [AUC], 0.870; 95% confidence interval [CI], 0.82–0.92). The nomogram was applied to the model validation group (AUC, 0.877; 95% CI, 0.80–0.95). When the sensitivity of the nomogram was 90%, the model was able to identify 52.3% low-RS and 41.2% high-RS cases not requiring ODX.

Conclusions
This was the first nomogram model developed based on data from a cohort of Japanese women. It may help determine the indications for ODX and the use of nomogram to identify cases requiring ODX may be economically beneficial.
Physiopathologische, klinische und therapeutische Aspekte des Morbus Darier
Authors: Ahn Soo Bin , Bernard Pauline , Blanchard Mael , Morren Marie-Anne , Ettinger Monika , Hötzenecker Wolfram , Guenova Emmanuella 
Published: July 2024

ZusammenfassungDer Morbus Darier (Dyskeratosis follikularis) ist eine seltene Genodermatose mit autosomal-dominanter Vererbung. Sie manifestiert sich typischerweise während der Pubertät durch braun-gelbliche, schuppige, krustig belegte Papeln in den Hautfalten und seborrhoischen Bereichen, begleitet von Nagelveränderungen und einer Beteiligung der Schleimhäute. Die Krankheit äußert sich durch schubartige Verläufe, die durch UV-Strahlung, Hitze, Reibung oder Infektionen ausgelöst werden können. Betroffene Patienten haben ein erhöhtes Risiko für Typ-1-Diabetes, Herzinsuffizienz und neuropsychiatrische Störungen. Für die kurzfristige Behandlung kommen Antibiotika/Virostatika, topische Kortikosteroide und/oder Retinoide zur Anwendung. Die langfristige Behandlung umfasst eine Systemtherapie mit Retinoiden und die Vermeidung von potenziellen Auslösefaktoren. Da es keine standardisierte Langzeittherapie gibt, werden in der Literatur zahlreiche lokale und systemische Behandlungen sowie physikalische und chirurgische Maßnahmen beschrieben.
The Effect of Social Transfers on Income Inequality and Poverty in Türkiye
Authors: Selim Raziye , Küçükçifçi Suat 
Published: July 2024

AbstractThis paper examines the effects of social transfers on inequality and poverty in Türkiye. We use Income and Living Conditions Survey that is conducted by TurkStat each year from 2006 to 2018. The social transfers include in cash and in-kind transfers from government to households. The standard budget incidence approach is used in the analysis. The redistribution impact of social transfers is measured using Gini coefficient and Suits coefficient and relative poverty rate. The equivalence scale adjustments are used for inequality and poverty estimations, and it is accepted as relative poverty approach. Pension income is the main factor that influences on reducing inequality and poverty. The inequality-reducing effect of pension income increased over time from 2005 to 2017. We also apply logistic regression analysis for 2018 SILC Survey. According to the logistic regression analysis, social transfers have the effect of reducing the probability of being poor in Türkiye.
Micro Knowledge as a Driver for Systemic Emergencies Management: The Case of Xylella in Italy
Authors: Latino Maria Elena , Menegoli Marta , Signore Fulvio , Corallo Angelo , De Devitiis Biagia , Viscecchia Rosaria 
Published: July 2024

AbstractDuring emergency production systems, supply chain stakeholders’ interactions, media activities, government actions, community behaviors are stressed bringing, all, to a high-risk perception about safety. For agri-food products, it became in a variation of consumers’ purchasing behaviors, guided by uncertainty and influenced by trust. The extant knowledge about consumers’ willingness to buy for agri-food products in emergency condition does not provide evidences during a phytosanitary warning. The proposed study, considering the Xylella fastidiosa phytosanitary emergency as case study, aims to fulfill this gap analyzing the possible variations of consumers’ perception and willingness to buy of Apulian olive oil in the era of Xylella emergence by adopting a multi-perspective and systemic approach. For achieving this scope, the study follows a Process-Person-Context-Time perspective for conceiving a systemic psychological model based on the Bronfenbrenner ecological model. Seven hypotheses were tested through Structural Equation Modeling thanks to a survey in a representative sample of 779 Italian consumers. Results showed that Italian consumer’s willingness to buy the post-Xylella olive oil can fluctuate due to the hypothesized system vulnerability: family, friends, and colleague such as trust in farmers and the credibility of Italian food market are impactful; trust in processors, transporters, and government and media is not. The findings, from theoretical and sectorial perspectives, provide new knowledge on the topic, empirical evidences, and a multi-systemic model able to analyze consumers’ behaviors, understand and stimulate the search for new (or more appropriate) marketing and communication strategies to face Xylella serious economic shortages, and to act a requalification of territory at all.
Navigating causal reasoning in sustainability science
Authors: Schlüter Maja , Hertz Tilman , Mancilla García María , Banitz Thomas , Grimm Volker , Johansson Lars-Göran , Lindkvist Emilie , Martínez-Peña Rodrigo , Radosavljevic Sonja , Wennberg Karl , Ylikoski Petri 
Published: July 2024

AbstractWhen reasoning about causes of sustainability problems and possible solutions, sustainability scientists rely on disciplinary-based understanding of cause–effect relations. These disciplinary assumptions enable and constrain how causal knowledge is generated, yet they are rarely made explicit. In a multidisciplinary field like sustainability science, lack of understanding differences in causal reasoning impedes our ability to address complex sustainability problems. To support navigating the diversity of causal reasoning, we articulate when and how during a research process researchers engage in causal reasoning and discuss four common ideas about causation that direct it. This articulation provides guidance for researchers to make their own assumptions and choices transparent and to interpret other researchers’ approaches. Understanding how causal claims are made and justified enables sustainability researchers to evaluate the diversity of causal claims, to build collaborations across disciplines, and to assess whether proposed solutions are suitable for a given problem.
Outcomes and Conclusions from the 2022 AM Bench Measurements, Challenge Problems, Modeling Submissions, and Conference
Authors: Levine Lyle , Lane Brandon , Becker Chandler , Belak James , Carson Robert , Deisenroth David , Glaessgen Edward , Gnaupel-Herold Thomas , Gorelik Michael , Greene Gretchen , Habib Saadi , Higgins Callie , Hill Michael , Hrabe Nik , Killgore Jason , Kim Jai Won , Lemson Gerard , Migler Kalman , Moylan Shawn , Pagan Darren , Phan Thien , Praniewicz Maxwell , Rowenhorst David , Schwalbach Edwin , Seppala Jonathan , Simonds Brian , Stoudt Mark , Weaver Jordan , Yeung Ho , Zhang Fan 
Published: July 2024

AbstractThe Additive Manufacturing Benchmark Test Series (AM Bench) provides rigorous measurement data for validating additive manufacturing (AM) simulations for a broad range of AM technologies and material systems. AM Bench includes extensive in situ and ex situ measurements, simulation challenges for the AM modeling community, and a corresponding conference series. In 2022, the second round of AM Bench measurements, challenge problems, and conference were completed, focusing primarily upon laser powder bed fusion (LPBF) processing of metals, and both material extrusion processing and vat photopolymerization of polymers. In all, more than 100 people from 10 National Institute of Standards and Technology (NIST) divisions and 21 additional organizations were directly involved in the AM Bench 2022 measurements, data management, and conference organization. The international AM community submitted 138 sets of blind modeling simulations for comparison with the in situ and ex situ measurements, up from 46 submissions for the first round of AM Bench in 2018. Analysis of these submissions provides valuable insight into current AM modeling capabilities. The AM Bench data are permanently archived and freely accessible online. The AM Bench conference also hosted an embedded workshop on qualification and certification of AM materials and components.
Impact of lower-respiratory tract infections on healthcare utilization and mortality in older adults: a Swedish population-based cohort study
Authors: Abbadi Ahmad , Gentili Susanna , Tsoumani Eleana , Brandtmüller Agnes , Hendel Merle K. , Salomonsson Stina , Calderón-Larrañaga Amaia , Vetrano Davide L. 
Published: July 2024

Abstract
Background
Lower respiratory tract infections (LRTIs) have an immediate significant impact on morbidity and mortality among older adults. However, the impact following the infectious period of LRTI remains understudied. We aimed to assess the short- to long-term impact of LRTIs on hospitalization, mortality, and healthcare utilization in older adults.

Methods
Data from the Swedish National Study of Aging and Care in Kungsholmen (SNAC-K) was analyzed, with data from 2001 to 2019 for mortality and 2001–2016 for healthcare utilization. LRTI-exposed participants were identified and matched with LRTI-nonexposed based on sociodemographics, lifestyle factors, and functional and clinical characteristics. Statistical models evaluated post-LRTI hospitalization risk, days of inpatient hospital admissions, healthcare visits, and mortality.

Results
567 LRTIs-exposed participants during the study period and were matched with 1.701 unexposed individuals. LRTI-exposed individuals exhibited increased risk of hospitalization at 1-year (HR 2.14, CI 1.74, 2.63), 3-years (HR 1.74, CI 1.46, 2.07), and 5-years (HR 1.59, CI 1.33, 1.89). They also experienced longer post-LRTI hospital stays (IRR 1.40, CI 1.18, 1.66), more healthcare visits (IRR 1.47, CI 1.26, 1.71), specialist-care visits (IRR 1.46, CI 1.24, 1.73), and hospital admissions (IRR 1.57, CI 1.34, 1.83) compared to nonexposed participants over 16-years of potential follow-up. Additionally, the 19-year risk of mortality was higher among LRTI-exposed participants (HR 1.45, CI 1.24, 1.70). Men exhibited stronger associations with these risks compared to women.

Conclusions
LRTIs pose both short- and long-term risks for older adults, including increased risks of mortality, hospitalization, and healthcare visits that transpire beyond the acute infection period, although these effects diminish over time. Men exhibit higher risks across these outcomes compared to women. Given the potential preventability of LRTIs, further public health measures to mitigate infection risk are warranted.
Das wahre Ich. Sexualität und Imperativ der Identität
Authors: Blattner Paul 
Published: July 2024

ZusammenfassungDieser Artikel beleuchtet die Verflechtung von der Frage nach der Sexualität und der Frage nach dem wahren Selbst. Durch die eigene Sexualität entdeckt und offenbart sich das Individuum vor sich selbst und anderen. Im Anschluss an die Werke von Michel Foucault zeigt sich, dass diese Befragung der eigenen Sexualität nicht nur ein epistemisches Unterfangen ist. Sie ist vielmehr eingebettet in eine größere Struktur von Macht und Wissen. Im Zentrum der Sexualität steht ein Imperativ der Identität, der vom Subjekt verlangt, sich innerhalb der Grenzen geltender Diskurse zu identifizieren und sich an bestehende Normen, die von den herrschenden Machtstrukturen produziert werden, zu orientieren und ihnen zu entsprechen. Abschließend werden zwei Pfade des Widerstands gegen diesen Imperativ der Identität beschrieben. Der eine betont die Möglichkeit, die Grenzen der Diskurse zu überschreiten, indem neue Wege gefunden werden, über sich selbst zu sprechen. Der andere eröffnet eine andere Perspektive auf die Sexualität, welche es uns ermöglicht, neue Beziehungen zu uns selbst und zu anderen zu gestalten.
Building a Better Wall: Assessing Children’s Design Technology Learning in Nature-Based Early Childhood Education
Authors: Speldewinde Christopher , Campbell Coral 
Published: July 2024

AbstractThe teaching and learning of design technology that occurs in nature-based early childhood education and care (ECEC) contexts such as nature kindergartens remains under-theorised. There is a growing body of scholarship that describes how teaching and learning occurs in these contexts as well as highlighting the benefits for young children learning in the natural environment. Recently, in the perspective of the Australian ECEC sector, how students experience design technology in nature-based contexts (bush kinders, an adaption of the European forest school approach to ECEC) was reported on. Despite design technology being accounted for in bush kinders as part of play-based learning of STEM, assessment of how this learning is supporting student’s comprehension of design technology remains an area for further attention. Often, educators rely solely on observations and anecdotal note taking for assessment which points to a need to support teachers with more rigorous assessment models. This paper adapts an assessment model for science learning and reconsiders it in terms of design technology teaching and learning. The paper’s aim is to support educators to develop children’s deeper understandings of design technology and make learning meaningful in nature-based education settings. Using vignettes, the children’s learning of design technology available in natural surroundings is analysed. This paper proposes that bush kinders are a valuable context for teaching and learning as they allow educators to develop skills to assess children’s design technology knowledge. The analysis of the data and its consideration against one play-based learning assessment model is also valuable in generating a broader narrative that deepens insights into the teaching and learning experience of design technology education in early childhood nature-based contexts.
A comprehensive analysis and comparison of lipid metabolism and inflammatory indices in patients with benign prostatic hyperplasia and prostate cancer
Authors: Xu Lei , Xu Yi , Chen Shouzhen , Shi Benkang 
Published: July 2024

Abstract
Aim
To investigate the role of metabolic indices in benign prostatic hyperplasia (BPH) and prostate cancer (PCa).

Methods
After exclusion of those with diabetes mellitus and incomplete characteristics, 552 PCa and 80 BPH patients who were diagnosed at Shandong University Affiliated Qilu Hospital between 2013 and 2022 were enrolled; and PCa patients were first compared to those with BPH in clinical characteristics. Then, we divided the patients into several groups according to the degree of risk and compared the variations in metabolic indices among the groups.

Results
Compared to those with BPH, patients with prostate cancer were significantly shorter (167.19±5.68 cm vs. 170.89±5.35 cm, p<0.001) and had greater BMI (25.13±3.06 kg/m2 vs. 24.25±3.08 kg/m2, p=0.019) and higher prealbumin (24.59±4.85 mg/dl vs. 23.21±4.76 mg/dl, p=0.017), TC (181.53±91.90 mg/dl vs. 167.71±30.20 mg/dl, p= 0.008), LDL (107.09±29.42 mg/dl vs. 100.22±25.01 mg/dl, p= 0.027), TG (120.74±135.60 mg/dl vs. 102.27±48.37 mg/dl, p= 0.020), and glucose levels (5.25±0.87 mmol/L vs. 5.04±0.62 mmol/L, p= 0.007). It seemed that PCa patients had a more severe inflammatory status, but this difference was not significant. However, no significant difference in PCa development was found for either the Gleason score or its extension.

Conclusion
PCa seems to be related to a more severe inflammatory status and more active metabolism, and lipid abnormalities are the main cause of prostate cancer, but the causal relationships between lipids and prostate cancer are still unclear and need further research.
Sparse modeling of dominant factors affecting porosity formation in laser powder bed fusion of aluminum alloy
Authors: Goto Ikuzo , Tsuchida Natsumi , Kawahara Masaaki 
Published: July 2024

AbstractThe dominant factors affecting porosity formation in laser powder bed fusion (PBF-LB/M) of an aluminum alloy were investigated through sparse modeling with the cross-sectional pore area ratio as the target variable and the process parameters of PBF-LB/M and the melting and solidification conditions of the alloy as the explanatory variables. A combination of a few explanatory variables that did not significantly increase the mean squared error for the relationship between the measured pore area ratios and the ratios estimated via the regression equations was found through lasso regression and backward elimination, which indicated that the energy density (one of the process parameters) and melt-pool depth (one of the melting conditions) were the dominant factors affecting the pore area ratio. The obtained regression coefficients for the energy density and melt-pool depth were negative and positive, respectively. In addition, the relationship between the energy density and melt-pool depth was curvilinear. These results suggest not only that the pore area ratio increases with the energy density and melt-pool depth but also that it decreases with an increase in the energy density or a decrease in the change rate of the pool depth under the range of the slow increase in the pool depth with an increase in the energy density.