bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polymorphisms in MicroRNAs Are Associated with Survival in Non–Small Cell Lung Cancer
Authors: Zhao Yang , Wei Qingyi , Hu Lingming , Chen Feng , Hu Zhibin , Heist Rebecca S. , Su Li , Amos Christopher I. , Shen Hongbing , Christiani David C. 
Published: August 2014

Abstract
Background: MicroRNAs (miRNA) play important roles in the regulation of eukaryotic gene expression and are involved in human carcinogenesis. Single-nucleotide polymorphisms (SNP) in miRNA sequence may alter miRNA functions in gene regulation, which, in turn, may affect cancer risk and disease progression.
Methods: We conducted an analysis of associations of 142 miRNA SNPs with non–small cell lung cancer (NSCLC) survival using data from a genome-wide association study (GWAS) in a Caucasian population from the Massachusetts General Hospital (Boston, MA) including 452 early-stage and 526 late-stage NSCLC cases. Replication analyses were further performed in two external populations, one Caucasian cohort from The University of Texas MD Anderson Cancer Center (Houston, TX) and one Han Chinese cohort from Nanjing, China.
Results: We identified seven significant SNPs in the discovery set. Results from the independent Caucasian cohort demonstrated that the C allele of rs2042253 (hsa-miRNA-5197) was significantly associated with decreased risk for death among the patients with late-stage NSCLC (discovery set: HR, 0.80; P = 0.007; validation set: HR, 0.86; P = 0.035; combined analysis: HR, 0.87; P = 0.007).
Conclusions: These findings provide evidence that some miRNA SNPs are associated with NSCLC survival and can be used as predictive biomarkers.
Impact: This study provided an estimate of outcome probability for survival experience of patients with NSCLC, which demonstrates that genetic factors, as well as classic nongenetic factors, may be used to predict individual outcome. Cancer Epidemiol Biomarkers Prev; 23(11); 2503–11. ©2014 AACR.
Regulation of OSU-03012 Toxicity by ER Stress Proteins and ER Stress–Inducing Drugs
Authors: Booth Laurence , Roberts Jane L. , Cruickshanks Nichola , Grant Steven , Poklepovic Andrew , Dent Paul 
Published: August 2014

AbstractThe present studies examined the toxic interaction between the non-coxib celecoxib derivative OSU-03012 and phosphodiesterase 5 (PDE5) inhibitors, and also determined the roles of endoplasmic reticulum stress response regulators in cell survival. PDE5 inhibitors interacted in a greater than additive fashion with OSU-03012 to kill parental glioma and stem-like glioma cells. Knockdown of the endoplasmic reticulum stress response proteins IRE1 or XBP1 enhanced the lethality of OSU-03012, and of [OSU-03012 + PDE5 inhibitor] treatment. Pan-caspase and caspase-9 inhibition did not alter OSU-03012 lethality but did abolish enhanced killing in the absence of IRE1 or XBP1. Expression of the mitochondrial protective protein BCL-XL or the caspase-8 inhibitor c-FLIP-s, or knockdown of death receptor CD95 or the death receptor caspase-8 linker protein FADD, suppressed killing by [OSU-03012 + PDE5 inhibitor] treatment. CD95 activation was blocked by the nitric oxide synthase inhibitor L-NAME. Knockdown of the autophagy regulatory proteins Beclin1 or ATG5 protected the cells from OSU-03012 and from [OSU-03012 + PDE5 inhibitor] toxicity. Knockdown of IRE1 enhanced OSU-03012/[OSU-03012 + PDE5 inhibitor]–induced JNK activation, and inhibition of JNK suppressed the elevated killing caused by IRE1 knockdown. Knockdown of CD95 blunted JNK activation. Collectively, our data demonstrate that PDE5 inhibitors recruit death receptor signaling to enhance OSU-03012 toxicity in glioblastoma multiforme (GBM) cells. Mol Cancer Ther; 13(10); 2384–98. ©2014 AACR.
Tissue factor, protease activated receptors and pathologic heart remodelling
Authors: Antoniak Silvio , Sparkenbaugh Erica , Pawlinski Rafal 
Published: August 2014

SummaryTissue factor is the primary initiator of coagulation cascade and plays an essential role in haemostasis and thrombosis. In addition, tissue factor and coagulation proteases contribute to many cellular responses via activation of protease activated receptors. The heart is an organ with high levels of constitutive tissue factor expression. This review focuses on the role of tissue factor, coagulation proteases and protease activated receptors in heart haemostasis and the pathological heart remodelling associated with myocardial infarction, viral myocarditis and hypertension.
Impact of anatomical location of lower limb venous thrombus on the risk of subsequent cancer
Authors: Arnoult Anne Cécile , Sevestre Marie-Antoinette , Genty Céline , Bonaldi Michael , Guyard Audrey , Giordana Pascal , Pichot Olivier , Colonna Marc , Quéré Isabelle , Bosson Jean-Luc , Galanaud Jean-Philippe ,   for the OPTIMEV-SFMV Investigators
Published: August 2014

SummaryAfter a proximal deep-vein thrombosis (P-DVT), the risk of diagnosis of a previously unsuspected cancer is high. Isolated distal DVT (iDDVT; i.e. infra-popliteal DVT without pulmonary embolism [PE]) and isolated superficial-vein thrombosis (iSVT; i.e. without concomitant DVT and PE) are at least as frequent as P-DVT but their association with subsequent cancer is uncertain. We exploited data from the OPTIMEV prospective, observational, multicentre study to i) compare the risk of subsequent cancer three years after a first objectively confirmed iSVT, iD-DVT and iP-DVT in patients without a prior history of cancer or of venous thromboembolism, ii) assess predictors of subsequent cancer in cases of iD-DVT. The overall cumulative rates of cancer among the 304 patients with iSVT, 536 patients with iD-DVT, and 327 patients with iP-DVT were similar (3.4% 95% confidence interval [1.8–6.2], 3.9% [2.5–5.9] and 3.9% [2.3–6.8], respectively), regardless of whether the index venous thromboembolic event was unprovoked or associated with a major transient risk factor. Neither anatomical (muscular vs deep-calf DVT) nor ultrasound scan characteristics (number of thrombosed veins, clot diameter under compression) seemed strongly associated with the risk of cancer in cases of iD-DVT. In patients managed in routine practice, all the different clinical expressions of lower limb venous thromboembolism are associated with a similar risk of subsequent cancer. From a clinical practice point of view, this suggests that cancer screening, without discussing the necessity, or not, of such screening, should not differ between a deepproximal, deep-distal or superficial location of thrombosis.Note: Part of this study was presented as an oral presentation at the 54th American Society of Hematology Annual Meeting, 8 to 11 December 2012, Atlanta, GA, USA.
Effects of Bariatric Surgery on Hepatic and Intestinal Lipoprotein Particle Metabolism in Obese, Nondiabetic Humans
Authors: Padilla Nadège , Maraninchi Marie , Béliard Sophie , Berthet Bruno , Nogueira Juan-Patricio , Wolff Estelle , Nicolay Alain , Bégu Audrey , Dubois Noémie , Grangeot Rachel , Mattei Catherine , Vialettes Bernard , Xiao Changting , Lewis Gary F. , Valéro René 
Published: August 2014

Objective—
The dyslipidemia of obesity and other insulin-resistant states is characterized by the elevation of plasma triglyceride-rich lipoproteins (TRL) of both hepatic (apoB-100–containing very low-density lipoprotein) and intestinal (apoB-48–containing chylomicrons) origin. Bariatric surgery is a well-established and effective modality for the treatment of obesity and is associated with improvements in several metabolic abnormalities associated with obesity, including a reduction in plasma triglycerides. Here, we have investigated the effect of bariatric surgery on TRL metabolism.

Approach and Results—

Twenty-two nondiabetic, obese subjects undergoing bariatric surgery: sleeve gastrectomy (n=12) or gastric bypass (n=10) were studied. Each subject underwent 1 lipoprotein turnover study 1 month before surgery followed by a second study, 6 months after surgery, using established stable isotope enrichment methodology, in constant fed state. TRL-apoB-100 concentration was significantly reduced after sleeve gastrectomy, explained by a decrease (
P
<0.05) in TRL-apoB-100 production rate and an increase (
P
<0.05) in TRL-apoB-100 fractional catabolic rate. TRL-apoB-48 concentration was also significantly reduced after sleeve gastrectomy, explained by reduction in TRL-apoB-48 production rate (
P
<0.05). For gastric bypass, although TRL-apoB-100 concentration declined after surgery (
P
<0.01), without a significant decline in TRL-apoB-48, there was no significant change in either TRL-apoB-100 or TRL-apoB-48 production rate or fractional catabolic rate. The reduction in TRL-apoB-100 concentration was significantly associated with a reduction in plasma apoC-III in the pooled group of patients undergoing bariatric surgery.

Conclusions—
This is the first human lipoprotein kinetic study to explore the mechanism of improvement of TRL metabolism after bariatric surgery. These effects may contribute to the decrease of cardiovascular mortality after surgery.

Clinical Trial Registration—

URL:
http://www.ClinicalTrials.gov
. Unique identifier: NCT01277068.
Adherence to Third European Cooperative Acute Stroke Study 3- to 4.5-Hour Exclusions and Association With Outcome
Authors: Cronin Carolyn A. , Sheth Kevin N. , Zhao Xin , Messé Steven R. , Olson DaiWai M. , Hernandez Adrian F. , Bhatt Deepak L. , Schwamm Lee H. , Smith Eric E. 
Published: August 2014

Background and Purpose—
The American Heart Association/American Stroke Association guidelines recommend intravenous tissue-type plasminogen activator (tPA) treatment 3 to 4.5 hours from symptom onset according to criteria used in the Third European Cooperative Acute Stroke Study (ECASS III). However, ECASS III excluded certain patient groups in addition to the standard exclusions used for 0 to 3 hours in the United States: age >80 years, history of stroke and diabetes mellitus, oral anticoagulant treatment, and National Institutes of Health Stroke Scale >25. We investigated adherence to these additional exclusion criteria for patients treated 3 to 4.5 hours from onset and their association with outcome.

Methods—
We analyzed data from Get With The Guidelines-Stroke on 32 019 patients with ischemic stroke from 1464 hospitals who were treated with tPA ≤4.5 hours from onset from January 2009 to January 2012, excluding patients transferred from another hospital. The percent of patients meeting versus not meeting each exclusion criterion were compared between treatment time windows.

Results—
Overall, 1544 of 4910 (31.5%) patients treated with tPA >3 to 4.5 hours had at least 1 of the additional exclusions, the most common was age >80 years. With the exception of prior stroke and diabetes mellitus, the percent of tPA–treated patients with each exclusion criterion was significantly lower at >3 to 4.5 hours compared with 0 to 3 hours. For each additional exclusion criterion, there was no increased risk of symptomatic intracranial hemorrhage or worse hospital outcome for patients treated >3 to 4.5 hours compared with 0 to 3 hours, after adjusting for baseline differences.

Conclusions—
Patients with ECASS III–specific exclusion criteria for the >3 to 4.5 hours window are frequently treated with tPA. The presence of the additional exclusion criteria was not associated with worse outcomes in the >3 to 4.5 hours window compared with the 0 to 3 hours window.
Large-Eddy Simulation of Stratified Turbulence. Part II: Application of the Stretched-Vortex Model to the Atmospheric Boundary Layer
Authors: Matheou Georgios , Chung Daniel 
Published: August 2014

Abstract
The buoyancy-adjusted stretched-vortex subgrid-scale (SGS) model is assessed for a number of large-eddy simulations (LESs) corresponding to diverse atmospheric boundary layer conditions. The cases considered are free convection, a moderately stable boundary layer [first Global Energy and Water Exchanges (GEWEX) Atmospheric Boundary Layer Study (GABLS)] case, shallow cumulus [Barbados Oceanographic and Meteorological Experiment (BOMEX)], shallow precipitating cumulus [Rain in Cumulus over the Ocean (RICO)] and nocturnal stratocumulus [Second Dynamics and Chemistry of the Marine Stratocumulus (DYCOMS-II) field study RF01]. An identical LES setup, including advection discretization and SGS model parameters, is used for all cases, which is a stringent test on the ability of LES to accurately capture diverse conditions without any flow-adjustable parameters. The LES predictions agree well with observations and previously reported model results. A grid-resolution convergence study is carried out, and for all cases the mean profiles exhibit good grid-resolution independence, even for resolutions that are typically considered coarse. Second-order statistics, for example, variances, converge at finer resolutions compared to domain means. The simulations show that 90% of the turbulent kinetic energy (at each level) must be resolved to obtain sufficiently converged mean profiles. This empirical convergence criterion can be used as a guide in designing future LES runs.
Zonally Symmetric Adjustment in the Presence of Artificial Relaxation
Authors: Hitchcock Peter , Haynes Peter H. 
Published: August 2014

Abstract
Numerical experiments, presented in a companion paper, have been performed in which the zonal-mean state of the stratosphere in a comprehensive, stratosphere-resolving, general circulation model is strongly relaxed (or “nudged”) toward the evolution of a reference sudden warming event in order to investigate its influence on the freely evolving troposphere below. Similar approaches have been used in a number of other studies. This raises the question of whether such an artificial relaxation induces the adiabatic and diabatic adjustments expected below the region of nudging, even in the absence of the stratospheric wave driving responsible for the reference event.
Motivated by this question, the zonally symmetric quasigeostrophic diabatic response to zonal forces (representing wave driving) in a system nudged to a time-dependent reference state is studied. In the presence of wave driving in the nudging region that differs from the reference state, the meridional mass circulation of the reference state is reproduced only in the region below the nudging up to a correction that is inversely proportional to the strength of the nudging. The anomalous circulation is confined because of an effective boundary condition at the interface of the nudging layer. The nudging also produces an artificial “sponge-layer feedback” immediately below the region of the nudging in response to differences in the tropospheric wave driving. The strength of this artificial feedback is closely related to the strength of the effective boundary condition; however, the time scale required for the sponge-layer feedback to be established is typically much longer than that required for the confinement.
Multivariate Minimum Residual Method for Cloud Retrieval. Part I: Theoretical Aspects and Simulated Observation Experiments
Authors: Auligné Thomas 
Published: August 2014

Abstract
A new method is presented for cloud detection and the retrieval of three-dimensional cloud fraction from satellite infrared radiances. This method, called multivariate minimum residual (MMR), is inspired by the minimum residual technique by Eyre and Menzel and is especially suitable for exploiting the large number of channels from hyperspectral infrared sounders. Its accuracy is studied in a theoretical framework where the observations and the numerical model are supposed perfect. Of particular interest is the number of independent information that can be found on the cloud according to the number of channels used. The technical implementation of the method is also briefly discussed. The MMR scheme is validated with the Atmospheric Infrared Sounder (AIRS) instrument using simulated observations. This new method is compared with the cloud-detection scheme from McNally and Watts that is operational at the European Centre for Medium-Range Weather Forecasts (ECMWF) and considered to be the state of the art in cloud detection for hyperspectral infrared sounders.
The Accountability–Well-Being–Ethics framework: A new philosophical foundation for occupational therapy
Authors: Taff Steven D. , Bakhshi Parul , Babulal Ganesh M. 
Published: August 2014

Background. The context that supported occupational therapy’s inception has been replaced with new challenges brought on by globalization and dramatic changes in health care. Thus, the profession’s philosophical grounding needs to be reframed to (a) achieve balance between science-driven and holistic elements, (b) operate within larger contexts on problems brought on by sociopolitical and natural determinants of health, and (c) maintain an ethical identity across all arenas of practice. Purpose. This paper presents a brief discussion of the philosophical underpinnings in occupational therapy’s history, outlines new global challenges for the profession, and proposes a new framework to address these challenges through education, practice, and research. Key Issues. Occupational therapy finds itself practising in a growing number of middle- and low-income countries where its roles and values need to be context and culture specific. Implications. The Accountability–Well-Being–Ethics framework guides the three domains of education, research, and practice to be relevant in an increasingly complex world.
A Comparison of Abdominal Muscle Thickness Changes After a Lifting Task in Subjects With and Without Chronic Low-Back Pain
Authors: Seyed Hoseinpoor Tahere , Kahrizi Sedighe , Mobini Bahram , Naji Mohsen 
Published: August 2014

Objective: Using ultrasound imaging, the abdominal muscles’ response to the back extensor muscle fatigue was assessed in subjects with chronic low-back pain (CLBP). Background: Lumbar muscle fatigue is a common occurrence among workers. Alteration in motor coordination is one consequence of muscular fatigue. According to previous studies, CLBP subjects use their back and abdominal muscles in different ways, but questions remain about abdominal muscle responses to back muscle fatigue in CLBP patients. Method: Thirteen CLBP patients and 15 healthy subjects participated in this study. The thickness of abdominal muscles—including transverse abdominis (TrA), internal oblique abdominis (IO), and external oblique abdominis (EO) muscles—was measured in standing position with and without axial loads before and after a lifting fatigue task. Results: The results reveal a significant difference for the main effects of group on percentage of change in TrA thickness ( F = 8.9, p = .004). Percentage of change in thickness of TrA was 10% greater in the CLBP group. Although IO thickness displayed greater percentage of change in the CLBP group, the difference between groups was not significant. Conclusion: Abdominal muscle behavior changes with back-muscle fatigue in both healthy and CLBP subjects, but responses were more exaggerated in CLBP patients. Application: Ultrasound imaging technique can provide critical information about the effect of fatigue on spinal muscle activation and consequently about the stability of the spine. As a more applicable and easy technique, ergonomists can use ultrasound imaging in musculoskeletal system assessment in worker populations in future studies.
Nomogram for Predicting Symptom Severity during Radiation Therapy for Head and Neck Cancer
Authors: Sheu Tommy , Fuller Clifton David , Mendoza Tito R. , Garden Adam S. , Morrison William H. , Beadle Beth M. , Phan Jack , Frank Steven J. , Hanna Ehab Y. , Lu Charles , Cleeland Charles S. , Rosenthal David I. , Gunn G. Brandon 
Published: August 2014

ObjectivesRadiation therapy (RT), with or without chemotherapy, can cause significant acute toxicity among patients treated for head and neck cancer (HNC), but predicting, before treatment, who will experience a particular toxicity or symptom is difficult. We created and evaluated 2 multivariate models and generated a nomogram to predict symptom severity during RT based on a patient‐reported outcome (PRO) instrument, the MD Anderson Symptom Inventory–Head and Neck Module (MDASI‐HN).Study DesignThis was a prospective, longitudinal, questionnaire‐based study.SettingTertiary cancer care center.Subjects and MethodsSubjects were 264 patients with HNC (mostly oropharyngeal) who had completed the MDASI‐HN before and during therapy. Pretreatment variables were correlated with MDASI‐HN symptom scores during therapy with multivariate modeling and then were correlated with the composite MDASI‐HN score during week 5 of therapy.ResultsA multivariate model incorporating pretreatment PROs better predicted MDASI‐HN symptom scores during treatment than did a model based on clinical variables and physician‐rated patient performance status alone (Akaike information criterion = 1442.5 vs 1459.9). In the most parsimonious model, pretreatment MDASI‐HN symptom severity (P <. 001), concurrent chemotherapy (P =. 006), primary tumor site (P =. 016), and receipt of definitive (rather than adjuvant) RT (P =. 044) correlated with MDASI‐HN symptom scores during week 5. That model was used to construct a nomogram.ConclusionOur model demonstrates the value of incorporating baseline PROs, in addition to disease and treatment characteristics, to predict patient symptom burden during therapy. Although additional investigation and validation are required, PRO‐inclusive prediction tools can be useful for improving symptom interventions and expectations for patients being treated for HNC.
Radiographic Landmarks for Locating the Femoral Origin and Tibial Insertion of the Knee Anterolateral Ligament
Authors: Helito Camilo Partezani , Demange Marco Kawamura , Bonadio Marcelo Batista , Tirico Luis Eduardo Passareli , Gobbi Riccardo Gomes , Pecora Jose Ricardo , Camanho Gilberto Luis 
Published: August 2014

Background: Recent anatomic studies have confirmed the presence of a true ligament structure, the anterolateral ligament (ALL), in the anterolateral region of the knee. This structure is involved in the rotatory instability of the knee and might explain why some isolated reconstructions of the anterior cruciate ligament result in a residual pivot shift. Therefore, when considering the least invasive method for reconstruction of this structure, it is important to identify the corresponding bony landmarks on radiographic images. Purpose: To establish radiographic femoral and tibial landmarks for the ALL in frontal and lateral views. Study Design: Descriptive laboratory study. Methods: Ten unpaired cadaver knees were dissected. The attachments of the ALL were isolated and its anatomic parameters were quantified. Its origin and insertion were marked with a 2-mm-diameter metallic sphere, and radiographs were taken from frontal and lateral views. The obtained images were analyzed and the ALL parameters established. Results: The origin of the ALL in the lateral view was found at a point an average ± SD of 47.5% ± 4.3% from the anterior edge of the femoral condyle and about 3.7 ± 1.1 mm below the Blumensaat line. In the frontal view, the origin was about 15.8 ± 1.9 mm from the distal condyle line. The ALL insertion was an average of 53.2% ± 5.8% from the anterior edge of the lateral tibial plateau in the lateral view and 7.0 ± 0.5 mm below the lateral tibial plateau in the frontal view. In anatomic dissections, the origin of the ALL was 1.9 ± 1.4 mm anterior and 4.1 ± 1.1 mm distal to the lateral collateral ligament, and the insertion was 4.4 ± 0.8 mm below the lateral tibial plateau cartilage. Conclusion: The ALL origin on an absolute lateral radiograph of the knee is approximately 47% of the anterior-posterior size of the condyle and 3.7 mm caudal to the Blumensaat line. In a frontal radiograph, the ALL is 15.8 mm from the posterior bicondyle line. The ALL insertion is approximately 53.2% of the anterior-posterior size of the plateau in the lateral view and 7.0 mm below the articular line in the frontal view. Clinical Relevance: Knowledge of the anatomic landmarks of the ALL on radiography will permit minimally invasive surgical reconstruction with lower morbidity.