bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relapse Hodgkin lymphoma autologous stem cell transplant long term follow up.
Authors: Abedrabo Sabree 
Published: July 2024

e19031 Background: Autologous Stem Cell Transplantation (ABMT) is a standard treatment approach for patients with relapsed Hodgkin’s Lymphoma (HL). We wish to report long term (>10 year) outcomes for patient’s with HL treated with ABMT at our institution. Methods: We treated 35 patients over a 30 year time period (1992-2022). Of these 35 patients, there were 19 males and 16 females with a median age of 41 years (range 21-70 years) and a median performance status of 1 (0-1). The preparative regimen was carmustine, etoposide, and melphalam (CEM, 1992-2005) and BCNU, etoposide, cytarabine and melphalan (BEAM, 2006 to present). Bretuximab was added to BEAM in 2018 as post-transplant consolidation therapy in 13 patients. All patients underwent mobilized peripheral blood stem collections with high dose filgrastim, and starting in 2008 were mobilized with both filgrastim and plexiform. The required stem cell product was at a minimum of 2 million CD34+ cells per kilogram of body weight. Results: Fifteen patients received CEEM and 9/15 (60%) achieved a complete response (CR). Twenty patients received BEAM and 16/20 (80%) achieved a CR, p=0.27 (Fisher’s exact test). The median time to hematological recovery was 12 days (range 8-21). Treatment related complications included: S. epidermis sepsis (3 patients), E. coli sepsis (3 patients), and esophageal perforation that lead to death in 1 patient. With a median follow up 13 years (range 1-23 years), the actual 10 year disease free survival (DFS) is 52% and overall survival (OS) is 64%. The actuarial DFS and OS at 15 years are 52% and 64% respectively. Six patients are in continuous CR for greater than 20 years. Long term complications at greater than 15 years include: cardiomyopathy (5 patients), breast cancer (1 patient), and liposarcoma (1 patient). Conclusions: Patients with relapsed HL can achieve long term curative outcomes when treated with ABMT with most frequent long term complication being cardiomyopathy.
Effects and outcomes of tumor lysis syndrome in patients admitted with Hodgkin and non-Hodgkin lymphoma: A National Inpatient Sample study (2019-2020).
Authors: Gaddam Mrunanjali , Iqbal Rabia , Jayakumar Jayalekshmi , Ginjupalli Manasa , Vachhani Bhavyakumar , Sanka Sujana , Thanneeru Priya , Sekandlapuram Rohit , Sanghvi Ankushi , Hotwani Priya , Nanavaty Dhairya , Kumar Vikash , Singh Surbhi , Colon Ramos Ana , Clement Jincy 
Published: July 2024

e19032 Background: Tumor Lysis Syndrome (TLS) is a life-threatening oncologic emergency. The newer advancement in therapeutic approaches in oncology has widened the range of malignancies associated with TLS. A lot of literature on the incidence of TLS in various solid malignancies exists. However, the effects of TLS on hematological malignancies, especially Hodgkin’s Lymphoma (HL) and Non-Hodgkin’s Lymphoma (NHL) have rarely been analyzed. Our study aims to identify the impact of TLS in patients hospitalized with HL and NHL and draw a comparison between HL and NHL. Methods: We analyzed the National Inpatient Sample database from 2019 - 2020 to identify patients > 18 years old with a primary diagnosis of HL and NHL. We compared the TLS prevalence and all-cause in-hospital mortality, length of hospital stay (LOS), and total costs in patients admitted with HL and compared it with NHL. Categorical variables were compared using the chi-square test, and the t-test compared continuous variables. Multivariable regression analyses were performed adjusting for demographics, hospital-level characteristics, and relevant comorbidities. Results: Among 24,550 Hodgkin’s Lymphoma (HL) hospitalizations and 108,060 Non-Hodgkin’s Lymphoma (NHL) hospitalizations, TLS was diagnosed in 0.69% of HL patients and 0.89% of NHL patients. In-hospital mortality was significantly higher in both HL (44.1%) and NHL (28.3%) patients with TLS compared to those without TLS (HL: 4.5%, NHL: 5.1%). Multivariate regression analysis revealed that TLS presence increased the chance of mortality among both HL (OR 17.9) and NHL (OR 7.3) patients. TLS also significantly impacted secondary outcomes including Acute Kidney Injury (AKI) and Hyperkalemia in both HL and NHL patients. No statistically significant differences were found in the odds of cardiac arrhythmias between HL and NHL patients with TLS (Table). TLS was associated with longer Length of Stay and higher total hospital costs in both HL and NHL patients compared to those without TLS. Conclusions: TLS is significantly associated with increased mortality in patients with HL and NHL, more in HL compared to NHL. In patients with HL, and NHL, TLS is an independent risk factor for in-patient mortality, the longer LOS, and the total cost, thereby incurring an increased burden on healthcare resources. Our study aims to highlight the need for greater vigilance in this vulnerable group when TLS occurs. [Table: see text]
Real-world adherence and healthcare resource utilization of Bruton tyrosine kinase inhibitors (BTKi) in mantle cell lymphoma.
Authors: Shah Bijal D. , Furnback Wesley , Esselman Kaitlyn , Chuang Po-Ya , Xue Mei , Yang Keri 
Published: July 2024

e19048 Background: This study aimed to examine treatment adherence and healthcare resource utilization (HCRU) of BTKi treatment in mantle cell lymphoma (MCL). Methods: The Symphony Integrated Dataverse (IDV) was used to conduct a retrospective observational study. Adult patients with MCL initiating their first BTKi or second BTKi (after ibrutinib) between 01/2020 and 10/2023 were included in the study. The index was defined as the date of BTKi initiation. Patients without 30 days of continuous enrollment pre- and post-index date were excluded. Patients were followed until the end of the study period or lost to follow-up. Adherence was evaluated by compliance and persistence. Compliance was calculated as the proportion of days covered >0.80 using 30-day intervals from initiation to 1 year. Persistence was measured as the proportion of patients who remained in treatment among patients with sufficient follow-up periods. HCRU was measured by all-cause outpatient visits, inpatient services, and other medical/hospital services per-patient-per-month (PPPM) during BTKi treatment. Results: Among 2,122 patients who were first-time BTKi users, there were significant differences for mean age at index (acalabrutinib=70; ibrutinib=68; zanubrutinib=70, P<.0001), commercial insurance (acalabrutinib=34%; ibrutinib=42%; zanubrutinib=47%, P<.0001), and baseline atrial fibrillation (acalabrutinib=1.94%; ibrutinib=1.24%; zanubrutinib=3.47%, P=0.0232). A total of 228 patients switched from ibrutinib to acalabrutinib or zanubrutinib. Adherence results suggested zanubrutinib had numerically better 1-year compliance ( P=0.2176) and treatment persistence at 1 and 2 years ( P=0.2687; P=0.6270) for patients who switched from ibrutinib to zanubrutinib or acalabrutinib (Table). HCRU showed that the mean (SD) outpatient visits (1.12 [1.67] vs 1.62 [3.17]; P=0.1755) and inpatient services (0.22 [0.68] vs 0.68 [3.12]; P=0.1693) were lower in patients switched from ibrutinib to zanubrutinib than acalabrutinib. Conclusions: In this study, zanubrutinib was associated with a trend towards improved compliance, persistence, and HCRU when used as the first BTKi and after prior ibrutinib. [Table: see text]
A phase I trial of intratumoral STX-001: A novel self-replicating mRNA expressing IL-12 alone or with pembrolizumab in advanced solid tumors.
Authors: Luke Jason J. , Kennedy Laura Carpin , Sankar Neil , Menzies Alexander M. , van Akkooi Alexander Christopher Jonathan , Gonzalez Maria , Urban Julie , Gill Mini , Atkins Cynthia M. , Quiñones Julian , Miller Brian , Duhamel Alison A. , Sowell Ryan T. , Nambiar Prashant R , Kitada Tasuku , Piha-Paul Sarina A. , Sankhala Kamalesh , Long Georgina V. 
Published: July 2024

TPS2696 Background: STX-001 is a multi-mechanistic lipid nanoparticle encapsulated synthetic self-replicating mRNA, engineered to express the IL-12 cytokine for an extended duration when administered intratumorally. A murine surrogate of STX-001 induces deep durable responses in multiple preclinical solid tumor models. This Phase 1 open-label, multi-center first-in-human dose-escalation trial evaluates the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary antitumor activity of STX-001 alone, or in combination with pembrolizumab in patients with treatment refractory advanced cancers. Methods: Approximately 30 adults ≥18 years of age with histologically confirmed advanced solid tumors that are refractory to standard treatments will be enrolled. The study will consist of two arms, an STX-001 monotherapy arm and an STX-001 + pembrolizumab combination arm, enrolling approximately 15 patients each. Key eligibility criteria include ECOG status 0 or 1, a tumor lesion amendable to injection, and confirmed prior disease progression. STX-001 will be administered every 3 weeks (q3w) for 3 doses and then every 6 weeks (q6w) for a further 3 doses. Tumor biopsies will be obtained at baseline and after the first STX-001 administration. Primary endpoints will include safety and maximum tolerated dose (MTD), with secondary endpoints encompassing pharmacokinetics and preliminary efficacy as measured by RECIST 1.1. To determine the MTD, this study will employ the Bayesian optimal interval (BOIN) design, with the 3 + 3 design run-in and a recommended phase 2 dose (RP2D) will be determined. Tumor response will be assessed using RECIST 1.1 criteria. Exploratory pharmacodynamic analyses will assess tumor-infiltrating lymphocytes and STX-001 mRNA in baseline and on-treatment biopsies, evaluate inflammatory cytokine profiles in plasma, determine immune activation in circulating immune cells, and measure circulating tumor DNA (ctDNA) for molecular response assessment. Clinical trial information: NCT06249048 .
Supporting students to return to study following course interruption (SuTuRe)
Authors: Luckett Alison 
Published: July 2024

Background: The pre-registration BSc Nursing course in the UK is renowned for being challenging due to its requirement for 2300 hours each for theoretical and practice-based learning. It is therefore inevitable that some students may need to interrupt their study at some point during the course. In many cases, these students do not return and leave the course, which has an impact on the future nursing workforce. Aims: To examine the reasons why pre-registration student nurses interrupt their studies and consider ways to enable them to return successfully and complete the course. Methods: The research project was based in one higher education institution (HEI) in the North West region of England. Interrupted students due to return to study in semester 1 of the 2022/23 academic year (n=95) were invited to participate in semi-structured interviews. Findings: Health, including mental health was the dominant factor leading to the interruption of study for the students. Conclusion: This research has led the HEI to introduce an improved support package for students. Alongside other recommendations it is hoped the changes will reduce attrition and lead to an improved interruption/return-to-study experience.
Mechanical Properties of Underutilized Hardwood Species and Potential for Use in Fabrication of Cross-Laminated Timber Industrial Mats
Authors: Ogunruku Mercy , França Tamara S. F. A. , França Frederico J. N. , Seale R. Daniel , Arango Rachel A. , Quesada Henry J. 
Published: July 2024

Abstract
This research evaluated the mechanical and physical properties of three underutilized hardwood species according to visual lumber grades. Findings are discussed in relation to the requirements recommended such as density, modulus of rupture (MOR), and modulus of elasticity (MOE) for the manufacture of cross-laminated timber (CLT) industrial mats, which is a potential end use of low-valued hardwood species. Results showed that all species tested had an average MOE greater than that required for CLT lumber. Visual grading was an important component in strength determinations as evidenced by the correlation between MOE and MOR. All grades of red oak (Quercus rubra L.) had higher densities than those of southern yellow pine, which is the traditional wood used in manufacturing CLT industrial mats, with a density of 616 kg/m3 at 12 percent moisture; the average density of the red oak tested was 770 kg/m3 at 13.98 percent moisture. All grades of red oak also had MOE and MOR values that met the requirements for lumber used in the manufacture of CLT industrial mats. For sweetgum (Liquidambar styraciflua L.), all grades met the required values for MOE and MOR, but only Grades 3 and 4 met the required density. All grades of yellow poplar (Liriodendron tulipifera L.) met the required MOE and MOR, but none met the required density.
Para qué sirve el diseño [Reseña]
Authors: Dalla-Fontana Paula 
Published: July 2024

Ejemplos, anécdotas, conceptos y claves. Para qué sirve el diseño es una bitácora guiada por Alberto y Oyer Corazón, en la que se plasma la esencia del diseño: lo que más importa es que funcione y luego está lo estético. En los primeros tres capítulos, se tratan temas como la verdadera labor del diseñador, el diseño como un proceso y el valor del diseño. Él último capítulo es dedicado a la modernidad y la incertidumbre, y cómo ambas afectan al diseño. El epílogo del libro, por su parte, es una inmersión más cercana al legado de Alberto Corazón a través de anécdotas relatadas por su hijo y un pequeño catálogo de sus obras más importantes. En general, a partir de una exposición sencilla y entendible para el lector medio, la obra es perfecta para quien se introduce al mundo del diseño y para que lo haga correctamente: teniendo muy presente el pensamiento y el análisis.
Mar abierto. ORE, CRAFT-OA, DIAMAS y otras iniciativas de ciencia abierta
Authors: Tur-Viñes Victoria 
Published: July 2024

La ciencia abierta y, en concreto, el acceso abierto a la ciencia va acercándose progresivamente a tierra firme. Para trasformar el amerizaje en aterrizaje conviene conocer en profundidad algunas iniciativas trascendentales. Tres de ellas revelan la perspectiva que tiene Europa sobre el acceso abierto (ORE, CRAFT-OA y Diamas). La tercera está protagonizada por los últimos ajustes que ha realizado ANECA en sexenios y en acreditaciones.
Reseña: Less Is More: How Degrowth Will Save The World de Jason Hickel.
Authors: Sosa Zancada Victoria 
Published: July 2024

Reseña: Less Is More: How Degrowth Will Save The World. Jason Hickel. Random House. Londres, 2020. Primera Edición. 336 páginas. ISBN: 978-1-473-58173-9.
Penerapan SOP dan Pemakaian APD dengan Kecelakaan Kerja pada Pekerja Depo Lokomotif
Authors: Pangestu Andro Faiq 
Published: July 2024

Depo Lokomotif PT. KAI (Persero) DAOP 4 adalah tempat perawatan rutin lokomotif pada tahun 2015 ditemukan kecelakaan kerja sebanyak 13 kasus (23,2%), tahun 2018 terjadi 15 kasus (26,7%) kecelakaan kerja. Tujuan penelitian ini untuk mengetahui adakah hubungan antara penerapan SOP dan pemakaian APD terhadap kejadian kecelakaan kerja pada pekerja depo lokomotif PT. KAI (Persero) DAOP 4 Semarang. Jenis penelitian ini adalah studi kuantitatif pendekatan analitik observasional strategi cross-sectional. Teknik pengambilan sampel menggunakan metode total sampling jadi jumlah sampel yaitu 56 pekerja. Penelitian ini dilaksanakan Juni-Oktober 2021. Hasil penelitian menunjukkan setelah dilakukan analisis bivariat hasil ρ-value hitung penerapan SOP dan pemakaian APD terhadap kejadian kecelakaan kerja berturut-turut 0,171 dan 0,338 lebih besar dari 0,05. Kesimpulan dari penilitian ini adalah tidak adanya hubungan yang signifikan antara penerapan SOP dan pemakaian APD dengan kecelakaan kerja pada pekerja depo lokomotif. Hal tersebut dikarenakan SOP yang diterapkan hanya pada pekerjaan tertentu saja dan konsistensi pekerja saat menggunakan APD.
Efektivitas Tim Reaksi Cepat
Authors: Azzahra Qurratul A'yun , Koesyanto Herry 
Published: July 2024

Indonesia tergolong Negara rawan bencana. Angka kejadian mencapai 2.925. Jenis penelitian yang digunakan adalah kualitatif deskriptif. Sumber informasi menggunakan data sekunder dan data primer. Hasil penelitian didapatkan kondisi Tim Reaksi Cepat BPBD Kota Semarang belum sepenuhnya efektif dilihat dari hambatan dengan nilai 60% dan koordinasi dengan nilai 80%. Proses penanggulangan bencana pada tahap prabencana belum efektif 60%, tanggap darurat 90%, dan pasca bencana 80%. Keefektifan TRC dilihat dari pencapaian tujuan sudah efektif dengan nilai 80%, adaptasi 90%, dan integrasi 90%. Yang mempengaruhi efektivitas dilihat dari efisiensi pelayanan dengan nilai 80% efektif, daya tanggap petugas dengan nilai 60% kurang efektif, sarana dan prasarana efektif dengan nilai 90%, semangat Kerjasama 60% kurang efektif dan hubungan pimpinan dengan bawahan dengan nilai 90% efektif. Saran yang peneliti rekomendasikan adalah TRC dapat meningkatkan koordinasi dengan dinas terkait, dan BPBD dapat meningkatan SDM serta dapat mengadakan pelatihan rutin untuk TRC.
The Perbedaan Tiga Kategori Aktifitas Fisik pada Status Obesitas dan Non Obesitas
Authors: Toar Jilly , Telew Agisteivie , Lumenta Griceria 
Published: July 2024

Prefalensi Obesitas tertingi di Indonesia yaitu Provinsi Sulawesi Utara dengan jumlah 31,2%. Salah satu Faktor terjadinya obesitas yaitu gaya hidup yang kurang aktif ataupun aktivitas fisik yang kurang. Obesitas selalu dikaitkan dengan aktivitas fisik. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran perbedaan 3 kategori aktivitas fisik pada status obesitas dan non obesitas. Penelitian ini merupakan penelitian case control dengan menggunakan data katagorik tidak berpasangan. Sampel penelitian ini berjumlah 190 sampel dengan pembagian sampel 95 status obesitas dan 95 status non obesitas. Analisis data menggunakan analisis data univariat. Dari hasil penelitian ini didapatkan bahwa responden berumur 17-25 tahun (2,6%), 26-35 tahun (37,8%), 36-45 tahun (30%), 46-55 tahun (24,2%), 56-65 tahun (5,3%). Jumlah responden jenis kelamin perempuan 108 rsponden (56,8%) dan laki-laki 82 responden (43,2%). Aktivitas ringan 3 responden (1,6%), aktivitas sedang 122 responden (64,2%) aktivitas berat 65 responden (34,2%). Jumlah aktivitas ringan dengan status obesitas 3,2% sedangkan non obesitas 0%. Aktivitas sedang dengan status obesitas 67,4% sedangkan non obesitas 61,1%. Aktivitas berat dengan status obesitas 38,9% sedangkan non obesitas 29,4%. Kesimpulannya rata-rata masyarakat desa klabat memiliki perilaku aktivitas fisik sedang yang dipengaruhi oleh jenis pekerjaan dan kemudahan-kemudahan dalam melakukan aktivitas seperti alat bantu pekerjaan maupun kemudahan dalam menggunakan alat transportasi.
Kata kunci : Aktivitas Fisik, Obesitas
Islamic Law and Environment Issues: Indonesian Ulama Council’s Fatwas on Climate Change
Authors: Harnowo Tri , Habib Fachry Hasani 
Published: July 2024

Climate change is critical as it impacts people’s lives on the globe. With the value of raḥmatan li al-’ālamīn, Muslims can contribute to the issue, one of which is by the issuance of fatwa. It is an opinion expressed by Islamic jurists regarding the legal position of a new societal issue when there is no explicit legal provision. Although non-binding, fatwas are essential guidelines for Muslims. In the context of climate change, fatwas can represent the moral position of Indonesian Muslims towards contemporary global issues. The study indicates that MUI has been progressive in responding to climate change through fatwas. These fatwas can be classified as having direct and indirect effects and conceptually related to climate change. However, fatwas that directly address climate change as a central issue are still lacking in MUI’s fatwas. Abstrak: Perubahan iklim sangatlah penting untuk dikaji karena hal itu berdampak pada kehidupan manusia di dunia. Dengan nilai raḥmatan li al-’ālamīn, umat Islam dapat berkontribusi dalam permasalahan tersebut yang di antaranya dengan dengan mengeluarkan fatwa. Fatwa merupakan pendapat yang dikemukakan oleh para ahli hukum Islam mengenai kedudukan hukum suatu persoalan masyarakat yang baru apabila tidak ada ketentuan hukum yang tegas. Meski tidak mengikat, fatwa merupakan pedoman penting bagi umat Islam. Dalam konteks perubahan iklim, fatwa dapat mewakili posisi moral umat Islam Indonesia terhadap isu-isu global kontemporer. Kajian ini menunjukkan bahwa Majelis Ulama Indoesia (MUI) telah bersikap progresif dalam menyikapi permasalahan ini melalui fatwa. Fatwa-fatwa tersebut dapat diklasifikasikan menjadi fatwa yang berdampak langsung dan tidak langsung secara konseptual yang terkait dengan perubahan iklim. Namun, fatwa yang secara langsung membahas perubahan iklim sebagai isu sentral masih belum ada dalam fatwa MUI.
Categorías de gestión interna de las áreas protegidas de la Universidad de Costa Rica
Authors: Morales Brenes Alexa , Marín Miranda Armando , Fernández Otárola Mauricio 
Published: July 2024

Las áreas protegidas son una de las mayores estrategias de conservación de la biodiversidad y servicios ecosistémicos. La clasificación de áreas protegidas en categorías de manejo de la Unión Internacional para la Conservación de la Naturaleza (UICN) constituyen un marco internacional de referencia. Este es reconocido por el Convenio sobre la Diversidad Biológica y busca categorizar los distintos modos de gestión aplicables a las áreas protegidas. Así, contribuye a la estandarización global de las áreas protegidas de acuerdo con sus objetivos de gestión, independiente de la nomenclatura de cada país. La Red de Áreas Protegidas de la Universidad de Costa Rica es una unidad de carácter multidisciplinario, dedicada actualmente a la protección de 15 áreas que resguardan recursos naturales diversos y que en conjunto suman 8 055 ha, propias o coadministradas por la Universidad. Estas áreas contribuyen a la conservación de la biodiversidad en las distintas propiedades de la Universidad, incluyendo Sedes y Recintos por todo el país. Ante la necesidad de establecer lineamientos adecuados para la organización y gestión adecuada de estas áreas, presentamos tres categorías de gestión internas: Reserva Biológica Universitaria, Área Universitaria de Gestión de Hábitats y Especies, y Área Universitaria de Gestión Sostenible de los Recursos. Estas, basadas en un análisis comparativo con las categorías de manejo de la UICN, según sus objetivos de creación y conservación, los enfoques primarios de su gestión, los rasgos distintivos de cada propiedad y su papel ecológico en el paisaje.
Los horizontes de la crítica en Bourdieu y sus efectos políticos
Authors: Juliao-Vargas Carlos German 
Published: July 2024

Este texto reflexivo, moviéndose entre teoría social y filosofía, se centra en la concepción de la crítica social bourdiana y su potencial político. Se parte de algunas objeciones a su visión sobre cómo funciona la crítica, sobre todo aquellas que afirmanque implica una noción objetivista de la cognición y de la agencia de las personas, se aclara que ellas se basan en una percepción errónea de la idea de Bourdieu sobre los niveles en los que ocurre la crítica. Luego se explora su comprensión de la lucha semántica que requiere la crítica social y lo que implica para cambiar la configuración dominante de lo social. Finalmente, se afirma que esta concepción de la crítica, aunque alejada del objetivismo, aún conserva cierta inclinación intelectualista.