bluuebunny/crossref_metadata_2025_split huggingface dataset:
Jakpreneur sebagai Upaya Pemerintah Provinsi DKI Jakarta Mempersiapkan ketahanan UMKM dalam menghadapi RCEP
Authors: Gultom Yosua Saut Marulitua , Saefulloh Riesky Ramdhani , Maharani Azzahra 
Published: August 2024

This article examines the opportunities and challenges faced by the Jakarta Provincial Government's initiative through the Jakpreneur program in improving the resilience of MSMEs amid the complexity of the RCEP regional trade agreement. This research is qualitative-based with a literature study with the concepts of economic resilience and MSMEs in International Relations. RCEP emphasizes the importance of MSMEs as a way to overcome the challenges of developing countries in the global supply chain. In Jakarta, the Jakpreneur program aims to empower MSMEs through training, access to financing, market linkages, and policy support, preparing them to take advantage of RCEP opportunities. The author highlights the interaction between Jakpreneur and RCEP, providing policy recommendations to strengthen MSMEs to face the free market. The conclusion of the article emphasizes the importance of special and different treatment for developing countries in RCEP, as well as the role of Jakpreneur in facilitating Jakarta MSMEs. Challenges faced include low competitiveness, limited access to financing, and inadequate infrastructure, but there are opportunities such as broader market access, international cooperation, and access to technology that can improve the competitiveness and efficiency of Jakarta MSMEs.

Artikel ini mengkaji peluang dan tantangan yang dihadapi oleh inisiatif Pemerintah Provinsi DKI Jakarta melalui program Jakpreneur dalam meningkatkan ketahanan Usaha Mikro, Kecil, dan Menengah (UMKM) di tengah kompleksitas perjanjian perdagangan regional RCEP. Penulis dalam penelitian ini berbasis kualitatif untuk melihat bagaimana Jakpreneur berperan dalam menghadapi RCEP. RCEP menekankan pentingnya UMKM sebagai cara mengatasi tantangan negara berkembang dalam rantai pasokan global. Di Jakarta, program Jakpreneur bertujuan memberdayakan UMKM melalui pelatihan, akses pembiayaan, hubungan pasar, dan dukungan kebijakan, mempersiapkan mereka untuk memanfaatkan peluang RCEP. Penulis menyoroti interaksi antara Jakpreneur dan RCEP, memberikan gambaran deskriptif terhadap Jakpreneur untuk memperkuat UMKM menghadapi pasar bebas. Kesimpulan artikel menegaskan pentingnya special and different treatmentuntuk negara berkembang dalam RCEP, serta peran Jakpreneur dalam memfasilitasi UMKM Jakarta. Tantangan yang dihadapi meliputi daya saing rendah, keterbatasan akses pembiayaan, dan infrastruktur yang kurang memadai, namun terdapat peluang seperti akses pasar yang lebih luas, kerja sama internasional, dan akses teknologi yang dapat meningkatkan daya saing dan efisiensi UMKM Jakarta.
МОЖЛИВОСТІ ПРЕДМЕТНОЇ ДІЯЛЬНОСТІ У ФОРМУВАННІ НАСКРІЗНОГО УМІННЯ ВИРІШУВАТИ ПРОБЛЕМИ
Authors: Засєкіна Тетяна , Козленко Олександр 
Published: August 2024

У статті розглянуто інноваційні підходи до формування змісту навчання на засадах діяльнісного підходу, що відповідає пріоритетній цілі реформи загальної середньої освіти. На прикладі біологічного матеріалу розкрито можливості досягнення обов’язкових результатів навчання через формування наскрізного уміння вирішувати проблеми. Запропоновано таку структуру видів діяльності учнівства, за якої навчальна, наукова або життєва проблема і сформований на її основі запит є основою обрання подальших способів дій: опрацювання інформаційних джерел і представлення інформації; планування та здійснення наукового дослідження, результати якого дозволять вирішити проблему; застосування усвідомлених уявлень про закономірності природи; співпраця, комунікація й колаборація як під час діяльності, так і після досягнення результату; втіленні сформульованих висновків у реальні дії в шкільній спільноті та в житті громади (агентність).
Antibacterial Test of Dadih Against Pathogenic Bacteria and Its Effects on Native Chicken Immunity Organs
Authors: Ginting Nurzainah , Yunilas  , Mirwandhono Edhi , Lin Y. Y. 
Published: August 2024

Dadih contains lactic acid bacteria that are antimicrobial so that it can be utilized to maintain the health of poultry such as native chickens. This study aims to prove the ability of dadih to suppress the growth of pathogenic bacteria, namely Staphylococcus aureus, Escherichia coli and Salmonella. This study will also try to find out invivo effect of dadih on the organ immunity of native chicken infected with Salmonella. Antimicrobial research uses disc diffusion method with antimicrobial zone parameter. The invivo study was conducted using a completely randomized design with 4 treatments and five replications where the parameter was the development of immunity organs namely thymus, bursa fabrisius and spleen. The results showed that the antimicrobial test of dadih against Staphylococcus aureus, Escherichia coli and Salmonella caused a zone of inhibition of 7.84, 6.63 and 8.34 mm. Dadih treatment significantly affected the percentage of thymus, bursa fabrisius and spleen. As conclusion that dadih is able to suppress the growth of Staphylococcus aureus, Escherichia coli and Salmonella at medium strength with a range of inhibition zone between 6.63-8.34. Dadih is also able to maintain the health of native chicken.
Gambaran Praktik Swamedikasi Masyarakat Kota Bengkulu Pada Penggunaan Obat Analgetik Antipiretik
Authors: Dari Dea Wulan , Iqoranny Susilo Avrilya 
Published: August 2024

Swamedikasi merupakan pengobatan mandiri yang sering dilakukan masyarakat untuk mengatasi gejala penyakit atau penyakit ringan seperti demam, nyeri, batuk, pusing, sakit maag, diare, penyakit kulit, cacingan, dan influenza. Swamedikasi ini memberikan keuntungan efisiensi waktu dan biaya dalam pengobatan karena tidak dilakukan konsultasi terlebih dahulu ke dokter untuk menentukan diagnosa dari penyakit yang dialami oleh masyarakat. Tujuan dari penelitian ini yaitu untuk mengetahui gambaran praktik swamedikasi masyarakat Kota Bengkulu pada penggunaan obat analgetik antipiretik. Metode penelitian yang digunakan pada penelitian ini adalah metode deskriptif dengan menggunakan lembar kuesioner yang sudah dilakukan validasi terlebih dahulu. Responden pada penelitian ini adalah masyarakat yang datang ke Apotek untuk melakukan swamedikasi. Dari hasil penghitungan rumus Slovin diperoleh jumlah sampel sebanyak 100 responden. Hasil dari penelitian ini diperoleh seluruh responden sudah pernah melakukan swamedikasi sebelumnya, paracetamol lebih banyak dipilih responden untuk mengatasi keluhan nyeri/demam (77%), keluhan penyakit yang dialami responden yaitu demam (72%), alasan melakukan swamedikasi paling banyak karena penyakit kategori ringan (39%), tempat pembelian obat swamedikasi lebih dominan di apotek (57%), efek setelah konsumsi obat merasakan sembuh (52%). Bila rasa nyeri/demam tidak berkurang setelah mengkomsumsi obat mayoritas responden akan pergi konsultasi ke dokter (72%), efek samping setelah minum obat tidak merasakan efek samping apapun (64%).Tingginya praktik swamedikasi di masyarakat membutuhkan pendampingan dari farmasis agar swamedikasi oleh masyarakat dilakukan dengan tepat dan benar.
PENDAMPINGAN POKJAKES LEMPUING INDAH DALAM MENINGKATKAN PENGETAHUAN DAN PERILAKU ANAK DAN KELUARGA TENTANG PERAWATAN GIGI DAN MULUT DI RW I KELURAHAN LEMPUING WILAYAH PUSKESMAS KOTA BENGKULU
Authors: Hartiana Hartiana , Pardosi Sariman , Wijaya Andra Saferi , Dahrizal Dahriza , Nugroho Nehru 
Published: August 2024

Abstrak

Karies gigi merupakan salah satu penyakit mulut yang ditandai dengan demeneralisasi jaringan gigi yang bersifat kronis keras kemudian diikuti dengan kerusakan zat organiknya yang menyebabkan hancurnya email dan dentin sehingga muncul lubang pada gigi. Karies gigi merupakan penyakit tidak menular yang sering dialami atau terjadi pada anak anak. (Soesilawati, 2020). Faktor yang menunjang tingginya angka prevalensi karies gigi anak yaitu anak anak pada umumnya menyukai makanan manis, apabila anak terlalu banyak makan gula-gula dan jarang membersihkannya maka akan menimbulkan akibat yakni gigi - giginya akan banyak yang mengalami karies gigi. Hal ini akan menjadi lebih parah. pemeliharaan kesehatan gigi dan mulut pada anak yang mengalami karies gigi, diperoleh data yaitu anak memiliki karies dentis (67%), sebagian besar anak mempunyai kebiasaan jajanan terbuka di sekolah (87%), dan masih ada anak yang tidak memeriksa kesehatan gigi ke pelayanan kesehatan (34%). Metode kegiatan pengabdian kepada masyarakat ini menggunakan metode pemberdayaan masyarakat dan partisipasi masyarakat dengan pendekatan keperawatan keluarga melalui pengenalan masalah, memutuskan merawat, merawat, memodifikasi lingkungan dan memanfaatkan fasilitas kesehatan. Rencana pelaksanaan kegiatan dialokasika di RW I Kelurahan Lempuing Kota Bengkulu. Evaluasi kegiatan dan monitoring dilakukan secara formatif dan sumatif melalui instrument yang telah disiapkan.
Kata Kunci: Karies gigi, Anak-anak, Pengetahuan
Gambaran Pola Konsumsi Protein Pada Ibu Hamil Kekurangan Energi Kronik (KEK) Di Wilayah Kerja Puskesmas Kandang Kota Bengkulu Tahun 2023 (Studi Kasus)
Authors: Anggela  
Published: August 2024

Protein di dalam tubuh manusia menjadi salah satu sumber utama energi. Protein sendiri mempunyai pengaruh yang cukup besar dalam kejadian kekurangan energi kronis (KEK), pada ibu hamil konsumsi protein sangat penting dan harus terpenuhi selama masa kehamilan untuk perkembangan janin, berkenaan dengan fungsi protein di dalam tubuh sebagai zat pembangun. Protein membangun sel jaringan serta meningkatkan imun tubuh. Tujuan penelitian ini adalah untuk mengetahui gambaran pola konsumsi protein pada ibu hamil KEK di wilayah kerja Puskesmas Kandang Kota Bengkulu.
Penelitian ini merupakan penelitian deskriptif. Desain studi observasional dengan pendekatan studi kasus. Hasil penelitian menunjukan pola konsumsi protein hewani pada ibu hamil KEK yang memiliki skor tertinggi dikelompok unggas yaitu Telur ayam 10,26, dikelompok ternak besar dan ternak kecil yaitu daging kerbau 1,053, dikelompok ikan air tawar yaitu ikan nila 5,26, dikelompok ikan air laut dan seafood yaitu ikan dencis 6,58, dikelompok makanan olahan yaitu susu 7,63 dan dikelompok pola konsumsi protein nabati yaitu tahu dengan skor 11,84. Dapat disimpulkan gambaran pola konsumsi protein hewani dan pola konsumsi protein nabati ibu hamil KEK masih kurang.

Kata Kunci: Pola Konsumsi, Protein, Ibu Hamil, KEK.
No genetic association between iron deficiency anemia and ischemic stroke and its subtypes: a bidirectional two-sample Mendelian randomization study
Authors: Chen Xingyu , Li Aiping , Zhou Wensheng , Yao Liping 
Published: August 2024

BackgroundObservational researches have suggested a connection between iron deficiency anemia (IDA) and an increased likelihood of ischemic stroke (IS), yet establishing causality is challenging owing to the inherent limitations of such studies, including their vulnerability to confounding factors and the potential for reverse causation. This study employs a bidirectional two-sample Mendelian randomization (MR) approach to assess the causal linkage between IDA and IS and its subtypes.MethodsIdentifiable single nucleotide polymorphisms (SNPs) with significant links to either IDA or IS and its subtypes were employed as instrumental variables (IVs). The relationship between IDA and any IS, small vessel stroke (SVS), cardioembolic stroke (CES), and large artery stroke (LAS), was quantified using the inverse variance weighted (IVW) method. Complementary analyses utilizing MR-Egger and weighted median methods further supplemented the IVW findings. Moreover, the leave-one-out analysis, MR-Egger intercept test, MR-PRESSO global test, and Cochrane’s Q test were conducted for sensitivity analyses.ResultsThis study revealed no correlation between IDA and any IS (IVW method: OR [95% CI] = 0.977 [0.863–1.106]; p = 0.716), LAS (OR [95% CI] = 1.158 [0.771–1.740]; p = 0.479), CES (OR [95% CI] = 1.065 [0.882–1.285]; p = 0.512), or SVS (OR [95% CI] = 1.138 [0.865–1.498]; p = 0.357). Conducting a reverse MR analysis, it was determined that there is no causal connection between any IS, LAS, CES, SVS, and IDA (all p &gt; 0.05). Sensitivity analysis indicated that heterogeneity was not significant and no evidence of horizontal pleiotropy was detected.ConclusionThis MR study suggested no causal effect of IDA on IS, LAS, CES, and SVS. Through reverse MR analyses, it was determined that IS and its subtypes did not exert a causal impact on IDA.
Comparison of ocular changes in multiple sclerosis and neuromyelitis optica spectrum disorder patients
Authors: Wang Xiaoyue , Bao Li 
Published: August 2024

PurposeTo explore ocular changes in patients with MS and NMOSD via SD-OCT and PVEP analysis.MethodsFrom August 2020 to July 2021, 82 patients (164 eyes) diagnosed with MS, 59 patients (118 eyes) diagnosed with NMOSD and 50 healthy controls (100 eyes) were retrospectively selected. SD-OCT and PVEP were performed to compare retinal nerve fibre layer (RNFL) thickness around the optic disc, ganglion cell inner plexiform layer (GCIPL) thickness in the macula and P100 latency and amplitude between the disease groups and the control group.ResultsIn the NMOSD and MS groups, the thickness of the GCIPL quadrants in eyes with optic neuritis was thinner than that in eyes without optic neuritis, and the amplitude of the P100 wave decreased. In addition, in eyes with optic neuritis, patients with NMOSD have thinner RNFL thicknesses in the temporal and superior quadrants than patients with MS, and the thickness of the GCIPL is thinner in each region. In eyes without optic neuritis, patients with MS have thinner nasal RNFL than do those with NMOSD.ConclusionSD-OCT and VEP may be useful for monitoring and distinguishing pathological changes in MS and NMOSD patients.
Exploring the genetic causal relationship between physical activity and migraine in European population based on Mendelian randomization analysis
Authors: Wang Jinfu , Yang Guan 
Published: August 2024

BackgroundPrevious studies have shown a connection between physical activity and migraines, but they don’t prove a cause-and-effect relationship due to potential biases in observational methods.MethodsUtilizing accelerometer-measured physical activity data from a cohort of 377,234 participants in the UK Biobank and information from 599,356 European migraine patients (including 48,975 cases and 550,381 controls) obtained from 24 cohorts, we performed a bidirectional Mendelian randomization analysis to investigate the genetic bidirectional causal relationship between accelerometer-measured physical activity and migraines.ResultsResearch findings indicated a slight negative genetic correlation between “average acceleration” physical activity (rg = −0.091, p = 0.011), overall physical activity (rg = −0.081, p = 0.017), and migraine. Nevertheless, no shared genetic components were observed between migraine and “fraction of accelerations &gt; 425 mg” of physical activity (rg = −0.124, p = 0.076). The study results also demonstrated a lack of genetic bidirectional causality between accelerometer-measured physical activity and migraine (“average acceleration”, OR = 1.002, 95% CI 0.975–1.031, p = 0.855, “fraction of accelerations &gt; 425 mg”, OR = 1.127, 95% CI 0.802–1.583, p = 0.488, overall physical activity, OR = 0.961, 95% CI 0.713–1.296, p = 0.799), and vice versa. Additionally, this lack of causal association persists even after adjusting for obesity (OR = 1.005, p = 0.578), education (OR = 1.019, p = 0.143), and depression (OR = 1.005, p = 0.847), either separately or simultaneously.ConclusionThe Mendelian randomization results based on genetic data do not provide support for a causal association between physical activity and migraine.
Assessment of Rab geranylgeranyltransferase subunit beta in amyotrophic lateral sclerosis
Authors: Yang Jing , Tian Mei , Zhang Lei , Xin Cheng , Huo Jia , Liu Qi , Dong Hui , Li Rui , Liu Yaling 
Published: August 2024

IntroductionGeranylgeranyltransferase Subunit Beta (RABGGTB) was expressed at higher levels in patients with Amyotrophic lateral sclerosis (ALS) compared with healthy controls. This study aims to observe the expression of RABGGTB in different cells from patients with ALS and different diseases.MethodsIn this case–control study, we collected peripheral blood from patients with ALS and healthy controls, and compared the expression of RABGGTB in natural killer cells (NK), T cells and B cells between patients with ALS and healthy controls by flow cytometry. And compared the expression of RABGGTB in monocytes and monocyte-derived macrophages from patients with ALS, Parkinson’s disease (PD), acute cerebrovascular disease (ACVD), and healthy controls by flow cytometry and immunofluorescence. Then flow cytometry was used to detect the expression of RABGGTB in monocytes from SOD1G93A mice and WT mice.ResultsThe expression of RABGGTB was not significantly changed in NK cells, cytotoxic T cells (CTL), helper T cells (Th), regulatory T cells (Treg), and B cells from patients with ALS compared to healthy controls. And the expression of RABGGTB in monocytes and monocyte-derived macrophages was higher in the ALS group than in the PD, ACVD and control group. The expression of RABGGTB was significantly higher in monocytes of SOD1G93A mice compared to WT mice.ConclusionThese findings suggest that RABGGTB expression was increased in monocytes and monocyte-derived macrophages from patients with ALS, not in NK, CTL, Th, Treg, and B cells. Future studies are needed to find the clinical implication of RABGGTB in ALS.
Exploring cross-modal plasticity in the auditory–visual cortex post cochlear implantation: implications for auditory and speech function recovery and mechanisms
Authors: Qiao Xiao-Feng , Liu Lu-Dan , Han Ling-Yan , Chen Ying , Li Xin 
Published: August 2024

ObjectiveThe aim of this is to explore changes in cross-modal reorganization within the auditory–visual cortex after cochlear implantation, examining their influence on auditory and speech functions along with their underlying mechanisms.MethodsTwenty prelingually deaf children who received cochlear implantation and rehabilitation training at our hospital between February 2022 and February 2023 comprised the prelingual deaf group. Simultaneously, 20 healthy children served as the control group. The prelingual deaf group underwent brain cortical activity assessment and evaluation of auditory-speech recovery pre-surgery, at postoperative weeks 1 and 2, and at months 1, 3, 6, 9, and 12. The control group underwent parallel assessments and evaluations. We analyzed the correlation between cortical activity in the auditory–visual cortex of patients and their auditory-speech functional recovery.ResultsThe group with prelingual deafness displayed elevated levels of auditory and visual cortical electromagnetic intensity compared to the control group, both prior to and 9 months after surgery. However, by the 12-month mark post-surgery, there was no discernible distinction between the two groups. Following surgery, the prelingually deaf group exhibited a progressive improvement in both Categories of Auditory Performance (CAP) and Speech Intelligibility Rate (SIR), initially lagging behind the control group. Notably, a negative correlation emerged between auditory and visual cortical electromagnetic intensity values and CAP/SIR scores at the 12-month post-surgery assessment.ConclusionCochlear implantation in prelingually deaf children results in elevated activity within the auditory and visual cortices, demonstrated by heightened electromagnetic intensity readings. Cross-modal reorganization is observed temporarily at 3 months post-surgery, which resolves to baseline levels by 12 months post-surgery. This phenomenon of reversal correlates with the restoration of auditory and speech functions in these children.
Persistent primary hyperparathyroidism caused by an ectopic adenoma in the piriform sinus: case report and review of the literature
Authors: Sardella Chiara , Seccia Veronica , Giambalvo Massimo , Pierotti Laura , Dinoi Elisa , Della Valentina Simone , Pardi Elena , Materazzi Gabriele , Dallan Iacopo , Berrettini Stefano , Cetani Filomena 
Published: August 2024

IntroductionPrimary hyperparathyroidism (PHPT) is a common endocrine disorder in which surgery is the only curative therapy. Ectopic parathyroid adenoma in the pyriform sinus resulting from a pathological migration of parathyroid glands along the embryological development is a rare cause of PHPT. We describe a case of a persistent primary hyperparathyroidism after previous unsuccessful surgery due to an ectopic parathyroid adenoma within the pyriform sinus and we review the previous reports on this issue.Case presentationA 62-year-old woman was referred for persistent hypercalcemia following unsuccessful cervical exploratory surgery. Cervical ultrasound did not detect any parathyroid abnormalities. At variance, 99mTc-sestamibi SPECT/CT and CT scan of the neck identified a parathyroid adenoma in the left pyriform sinus, which was confirmed by endoscopy. The patient was successfully treated by transoral robotic resection and the pathology confirmed a parathyroid adenoma.ConclusionsThe ectopic parathyroid adenoma in the pyriform sinus is so uncommon that only fourteen cases have been reported. However, the pyriform sinus should be considered a possible location of ectopic parathyroid glands, especially in the setting of persistent or recurrent PHPT after parathyroid surgery.
Neurodevelopmental disorders in children seeking obesity treatment- associations with intellectual ability and psychiatric conditions
Authors: Dellenmark-Blom Maria , Järvholm Kajsa , Sjögren Lovisa , Levinsson Anna , Dahlgren Jovanna 
Published: August 2024

BackgroundNeurodevelopmental disorders (NDD), psychiatric comorbidity and cognitive deficits are commonly seen in children with obesity; however, little is known about the overlap between these conditions. This study aimed to examine the undiagnosed and diagnosed frequency of NDDs and explore its association with psychiatric conditions and general intellectual ability (IQ) in children presenting for obesity treatment.MethodsIn this observational study at two outpatient obesity clinics during 2018-2019, 80 children (8-17 years) were consecutively recruited, and screened for NDD unless already diagnosed with an NDD. A psychiatric unit evaluated children who screened positive for NDD. Diagnoses and clinical background factors were collected from medical records. IQ was assessed with the Weschler Intelligence Scales and internalizing symptoms were assessed using the Beck Youth Inventories. Associations between background factors, IQ and internalizing symptoms were explored in relation to having an NDD or not.ResultsWe found that 47/80 children had at least one NDD. Children with a diagnosed NDD before study start (n = 30) had significantly more comorbidities than children diagnosed after the study screening (n = 17) (P = .01). Greater cognitive impairment was seen in children with NDD compared with children without an NDD (P = .01). Also, 33/73 participants self-reported substantial internalizing symptoms. At follow-up, 21/79 participants, in addition to NDD, had been diagnosed with another psychiatric disorder. Ten of these were children that had been diagnosed with an NDD before study start.ConclusionThe overlap between NDD, cognitive deficits and psychiatric conditions in children with obesity is an important consideration for clinical practice. Screening for these conditions may be necessary when providing targeted interventions.