bluuebunny/crossref_metadata_2025_split huggingface dataset:
Draft Genome Sequences of Mycobacterium bovis BZ 31150 and Mycobacterium bovis B2 7505, Pathogenic Bacteria Isolated from Archived Captive Animal Bronchial Washes and Human Sputum Samples in Uganda
Authors: Wanzala Sylvia I. , Nakavuma Jesca , Travis Dominic A. , Kia Praiscillia , Ogwang Sam , Sreevatsan Srinand 
Published: October 2015

ABSTRACT

Bovine tuberculosis (BTB), a zoonotic infection of cattle caused by
Mycobacterium bovis
, results in losses of $3 billion to the global agricultural industry and represents the fourth most important livestock disease worldwide.
M. bovis
as a source of human infection is likely underreported due to the culture medium conditions used to isolate the organism from sputum or other sample sources. We report here the draft genome sequences of
M. bovis
BZ 31150, isolated from a bronchial washing from a captive chimpanzee, and
M. bovis
B2 7505, isolated from a human sputum sample in Uganda.
Draft Genome Sequence of Lactobacillus johnsonii Strain 16, Isolated from Mice
Authors: Buhnik-Rosenblau Keren , Danin-Poleg Yael , Elgavish Sharona , Kashi Yechezkel 
Published: October 2015

ABSTRACT

Here, we report the genome sequence of
Lactobacillus johnsonii
, a member of the gut lactobacilli. This draft genome of
L. johnsonii
strain 16 isolated from C57BL/6J mice enables the identification of bacterial genes responsible for host-specific gut persistence.
Complete Genome Sequence of the Acetogenic Bacterium Moorella thermoacetica DSM 2955
T
Authors: Bengelsdorf Frank R. , Poehlein Anja , Esser Carola , Schiel-Bengelsdorf Bettina , Daniel Rolf , Dürre Peter 
Published: October 2015

ABSTRACT

Here, we report the complete genome sequence of
Moorella thermoacetica
DSM 2955
T
, an acetogenic bacterium, which uses the Wood–Ljungdahl pathway for reduction of H
2
+ CO
2
or CO. The genome consists of a single circular chromosome (2.62 Mb).
Draft Genome Sequence of Enteropathogenic Escherichia coli, Isolated from the Bloody Stool Sample of a Common Marmoset (Callithrix jacchus)
Authors: Hayashimoto Nobuhito , Morita Hanako , Inoue Takashi , Yasuda Masahiko , Yamamoto Masafumi , Itoh Toshio 
Published: October 2015

ABSTRACT

Here, we report the draft genome sequence of
Escherichia coli
strain R811. This bacterium was isolated from the bloody stool sample of a common marmoset, and was categorized as enteropathogenic
E. coli
because it possessed
eae
.
Draft Genome Sequence of Xanthomonas translucens pv. graminis Pathotype Strain CFBP 2053
Authors: Pesce Céline , Bolot Stéphanie , Berthelot Edwige , Bragard Claude , Cunnac Sébastien , Fischer-Le Saux Marion , Portier Perrine , Arlat Matthieu , Gagnevin Lionel , Jacques Marie-Agnès , Noël Laurent D. , Carrère Sébastien , Koebnik Ralf 
Published: October 2015

ABSTRACT

Strains of
Xanthomonas translucens
pv. graminis cause bacterial wilt on several forage grasses. A draft genome sequence of pathotype strain CFBP 2053 was generated to facilitate the discovery of new pathogenicity factors and to develop diagnostic tools for the species
X. translucens
.
Draft Genome Sequences of Two Lipopeptide-Producing Strains of Bacillus methylotrophicus
Authors: Jeukens Julie , Kukavica-Ibrulj Irena , Freschi Luca , Jabaji Suha , Levesque Roger C. 
Published: October 2015

ABSTRACTBacillus methylotrophicusis implicated in phytostimulation and disease suppression of agricultural and bioenergy crops. Here, we present the genome sequences ofB. methylotrophicusstrains B26 and OB9. Their assembly resulted in 26 and 24 contigs, respectively. These strains are well suited for comparative genomics studies and the evaluation of commercially valuable biomolecular compounds.
Draft Genome Sequence of Mizugakiibacter sediminis skMP5
T
Authors: Watanabe Tomohiro , Kojima Hisaya , Fukui Manabu 
Published: October 2015

ABSTRACT

Strain skMP5
T
is a moderately thermophilic and facultatively anaerobic bacterium, described as a representative of
Mizugakiibacter sediminis
. Here, we report the annotated draft genome sequence of strain skMP5
T
.
Labour and delivery interventions in women with intellectual and developmental disabilities: a population-based cohort study
Authors: Brown Hilary K , Kirkham Yolanda A , Cobigo Virginie , Lunsky Yona , Vigod Simone N 
Published: October 2015

BackgroundOur objectives were to: (1) examine the occurrence of labour induction, caesarean section, and operative vaginal delivery in women with intellectual and developmental disabilities compared to those without and (2) determine whether pre-pregnancy health conditions and pregnancy complications explain any elevated occurrence of these interventions.MethodsWe conducted a population-based study using linked Ontario (Canada) administrative data. We identified deliveries to women with (N=3932) and without (N=382 774) intellectual and developmental disabilities (2002–2011). Modified Poisson regression was used to estimate adjusted relative risks (aRR) and 95% CIs for interventions, controlling for sociodemographic characteristics. We used generalised estimating equations to determine whether pre-pregnancy health conditions and pregnancy complications explained any statistically significantly elevated aRRs.ResultsAfter controlling for socio-demographic characteristics, women with intellectual and developmental disabilities were more likely to have labour inductions (aRR, 1.13; 95% CI 1.06 to 1.20) and caesarean sections (aRR, 1.09; 95% CI 1.03 to 1.16) but not operative vaginal deliveries, compared to the referent group. Pre-pregnancy health conditions explained 12.9% of their elevated aRR for labour induction. Pre-pregnancy health conditions and maternal complications explained 27.8% and 13.3%, respectively, of their elevated aRR for caesarean section.ConclusionsWomen with intellectual and developmental disabilities are slightly more likely to have labour inductions and caesarean sections than women without intellectual and developmental disabilities. The elevated occurrence of these interventions is not fully explained by their pre-pregnancy health conditions or pregnancy complications. Non-medical issues should be evaluated for their influence on the timing of labour and delivery in this population.
Obesity, Insulin Resistance, and Incident Small Vessel Disease on Magnetic Resonance Imaging
Authors: Dearborn Jennifer L. , Schneider Andrea L.C. , Sharrett A. Richey , Mosley Thomas H. , Bezerra Daniel C. , Knopman David S. , Selvin Elizabeth , Jack Clifford R. , Coker Laura H. , Alonso Alvaro , Wagenknecht Lynne E. , Windham Beverly G. , Gottesman Rebecca F. 
Published: October 2015

Background and Purpose—
The term metabolic syndrome describes the clustering of risk factors found in many individuals with obesity. Because of their pathophysiology, we hypothesized that 2 features of metabolic syndrome, central obesity and insulin resistance (IR), would be associated with cerebrovascular changes on magnetic resonance imaging, and specifically with incident lacunar disease and not white matter hyperintensity (WMH) progression.

Methods—
Risk factors were defined at study baseline in 934 participants in the Atherosclerosis Risk in Communities (ARIC) study, who completed 2 brain magnetic resonance imagings ≈10 years apart. WMH progression and incident lacunes between the 2 magnetic resonance imagings were determined. An IR score for each participant was created using principal component analysis of 11 risk factors, including (among others): insulin, homeostatic model assessment-IR, body mass index, and waist circumference. Metabolic syndrome (presence/absence), using standard clinical definitions, and IR score at the first magnetic resonance imaging, were independent variables, evaluated in multivariate logistic regression to determine odds of WMH progression (Q5 versus Q1–Q4) and incident lacunes.

Results—
Metabolic syndrome (adjusted odds ratio, 1.98; 95% confidence interval, 1.28–3.05) and IR score (adjusted odds ratio per 1-SD increase, 1.33; 95% confidence interval, 1.05–1.68) were associated with incident lacunes but not with WMH progression. Insulin, homeostatic model assessment-IR, and body mass index were not associated with incident lacunes or WMH progression in separate models.

Conclusions—
The IR score and central obesity are associated with incident lacunar disease but not WMH progression in individuals. Central obesity and IR may be important risk factors to target to prevent lacunar disease.
Early Loss of Immediate Reperfusion While Stent Retriever in Place Predicts Successful Final Reperfusion in Acute Ischemic Stroke Patients
Authors: Okawa Masakazu , Tateshima Satoshi , Liebeskind David , Rao Neal , Jahan Reza , Gonzalez Nestor , Szeder Viktor , Ali Latisha , Kim Doojin , Saver Jeffrey , Duckwiler Gary 
Published: October 2015

Background and Purpose—
Degree of stent retriever engagement with target thrombi may be reflected by (1) immediate reperfusion (IR) on first deployment, indicating displacement of clot toward the vessel wall, and (2) by early loss of IR (ELOIR), indicating penetration of retriever struts through the thrombus. The relation of these early findings to final reperfusion and clinical outcomes has not been well delineated.

Methods—
We investigated IR and ELOIR in patients undergoing stent retriever mechanical thrombectomy at an academic medical center between March 2012 and June 2014.

Results—

Among 56 patients, IR itself was not associated with final successful reperfusion, which occurred in 66.7% of IR patients and 71.4% of non-IR patients (
P
=0.999). However, ELOIR was associated with a higher rate of final successful reperfusion (92% versus 44%;
P
=0.046). Patients with ELOIR had a higher nominal rate of final favorable outcome (42% versus 22%;
P
=0.64).

Conclusions—
ELOIR during the embedding period after deployment of stent retrievers is associated with successful final reperfusion, likely because of greater thrombus engagement with the stent retriever. ELOIR may be a useful finding to guide duration of embedding time in clinical practice and design of novel stent retrievers.
A First Evaluation of ERA-20CM over China
Authors: Gao Lu , Bernhardt Matthias , Schulz Karsten , Chen Xingwei , Chen Ying , Liu Meibing 
Published: October 2015

Abstract
As an important global data resource, reanalysis is widely applied for climate impact studies of the past several decades. For the first time, monthly mean temperature and monthly total precipitation derived from the newest generation reanalysis product—the ECMWF twentieth-century reanalysis dataset (ERA-20CM)—is quantitatively evaluated based on probability density functions and 702 meteorological stations during the period of 1960–2009 across China. This study attempts to investigate how well each member ensemble prediction of ERA-20CM performs for different regions. Generally, all ensemble predictions in ERA-20CM are able to recreate the real conditions on a comparable level. More than 90% of the observed probability for temperature and more than 80% of the probabilities for precipitation could be captured by ERA-20CM over China. However, the performance changes significantly from region to region because of different topographical features and climate characteristics. The Tibetan Plateau is the most difficult to model for all member ensembles. The Jianhuai region is the area with the best performance for both temperature and precipitation. Although the best and worst ensembles for temperature and precipitation for each region were selected according to the skill scores, the differences among the 10-member ensemble predictions are negligible. This evaluation would be helpful for the potential users of reanalysis data, such as ERA-20CM for local climate impact assessments in China.
An Automated, Multiparameter Dryline Identification Algorithm
Authors: Clark Adam J. , MacKenzie Andrew , McGovern Amy , Lakshmanan Valliappa , Brown Rodger A. 
Published: October 2015

Abstract
Moisture boundaries, or drylines, are common over the southern U.S. high plains and are one of the most important airmass boundaries for convective initiation over this region. In favorable environments, drylines can initiate storms that produce strong and violent tornadoes, large hail, lightning, and heavy rainfall. Despite their importance, there are few studies documenting climatological dryline location and frequency, or performing systematic dryline forecast evaluation, which likely stems from difficulties in objectively identifying drylines over large datasets. Previous studies have employed tedious manual identification procedures. This study aims to streamline dryline identification by developing an automated, multiparameter algorithm, which applies image-processing and pattern recognition techniques to various meteorological fields and their gradients to identify drylines. The algorithm is applied to five years of high-resolution 24-h forecasts from Weather Research and Forecasting (WRF) Model simulations valid April–June 2007–11. Manually identified dryline positions, which were available from a previous study using the same dataset, are used as truth to evaluate the algorithm performance. Generally, the algorithm performed very well. High probability of detection (POD) scores indicated that the majority of drylines were identified by the method. However, a relatively high false alarm ratio (FAR) was also found, indicating that a large number of nondryline features were also identified. Preliminary use of random forests (a machine learning technique) significantly decreased the FAR, while minimally impacting the POD. The algorithm lays the groundwork for applications including model evaluation and operational forecasting, and should enable efficient analysis of drylines from very large datasets.
Development of an Educational Program on Prevention of Hypoglycemic Events Among Elderly Veterans With Type 2 Diabetes
Authors: Meulstee Maud , Whittemore Robin , Watts Sharon A. 
Published: October 2015

Purpose The purpose of this project was to develop an evidence-based educational program to reduce hypoglycemic events in elderly veterans with type 2 diabetes mellitus who are enrolled in the Veterans Healthcare Administration system. Updated guidelines have emphasized the importance of hypoglycemia prevention, and they recommend individualized and less stringent glycemic control. Methods A comprehensive literature review was conducted, which led to the development of evidence-based content for an educational program. Several categories and subcategories of content were identified and subsequently evaluated by a panel of experts in the field of diabetes management. Results Experts were unanimous on the importance and relevance of the categories and provided insight into the priority of subcategories of content. Conclusions Developing an evidence-based educational program for health care providers on prevention of hypoglycemia has important clinical implications. Diabetes educators can use the topical outline for patient and family teaching. This project may also serve as an example for diabetes educators on developing evidence-based educational programs.
Therapeutic validity and effectiveness of supervised physical exercise training on exercise capacity in patients with chronic obstructive pulmonary disease: a systematic review and meta-analysis
Authors: Vooijs Martijn , Siemonsma Petra C , Heus Inge , Sont Jacob K , Rövekamp Ton AJM , van Meeteren Nico LU 
Published: October 2015

Objective: Our aim was to determine the effectiveness of supervised physical exercise training on exercise capacity in patients with chronic obstructive pulmonary disease taken into consideration indices such as therapeutic validity of interventions, methodological quality of studies, and exercise volume. Data resources: MEDLINE, Cochrane Central Register of Controlled Trials, EMBASE, CINAHL, and PEDro databases were searched from inception until 17 July 2015 for randomized controlled trials comparing the effect of supervised exercise training vs. usual care in patients with chronic obstructive pulmonary disease. The references of included studies and review articles were hand searched for additional references and key authors of included trials were crosschecked in PubMed for any missed references. Review methods: Two reviewers independently assessed therapeutic validity of exercise training and methodological quality of included studies. Overall effects were calculated using a random effects model. Results: A total of 13 studies involving 756 patients with chronic obstructive pulmonary disease were included. Significant differences in maximal exercise capacity (standardized mean difference 0.52, 95% CI 0.31 to 0.74) and endurance exercise capacity (standardized mean difference 0.73, 95% CI 0.50 to 0.96) in favor of physical exercise training were found. The volume of physical exercise per week, the total volume of physical exercise, or their associations did not significantly influence the effect of training. Conclusion: Effects of supervised physical exercise was not significantly altered by therapeutic validity. A combination of aerobic exercise and strength training was found to be more effective than strength training or endurance training alone in increasing the 6-minute walking distance.
Inflammatory Cytokines and Matrix Metalloproteinases in the Synovial Fluid After Intra-articular Ankle Fracture
Authors: Adams Samuel B. , Setton Lori A. , Bell Richard D. , Easley Mark E. , Huebner Janet L. , Stabler Thomas , Kraus Virginia B. , Leimer Elizabeth M. , Olson Steven A. , Nettles Dana L. 
Published: October 2015

Background: Posttraumatic osteoarthritis (PTOA) can occur after intra-articular fracture despite anatomic fracture reduction. It has been hypothesized that an early inflammatory response after intra-articular injury could lead to irreversible cartilage damage that progresses to PTOA. Therefore, in addition to meticulous fracture reduction, it would be ideal to prevent this initial inflammatory response but little is known about the composition of the synovial environment after intra-articular fracture. The purpose of this work was to characterize the inflammatory cytokine and matrix metalloproteinase (MMP) composition in the synovial fluid (SF) of patients with acute intra-articular ankle fractures. Methods: Twenty-one patients with an intra-articular ankle fracture were included in this study. All patients had a contralateral ankle joint that was pain free, had no radiographic evidence of arthritis, and no history of trauma. The uninjured ankle served as a matched control. SF was obtained from bilateral ankles at the time of surgery which occurred at a mean of 17 days post-fracture (range 8-40). The SF was analyzed for granulocyte macrophage colony-stimulating factor (GM-CSF), interferon-gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), interleukin (IL)-1β, IL-2, IL-6, IL-8, IL-10, IL-12p70, MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, CTXII, sGAG, and bilirubin/biliverdin (markers of hemearthrosis) using either multiplex assay or ELISA using commercially available kits. Mean concentrations of each factor were compared between SF from fractured and control ankles, and correlation analysis was done to determine potential relationships between levels of cytokines and time from fracture and age at fracture. Results: Twelve of 18 measured factors including GM-CSF, IL-10, IL-1β, IL-6, IL-8, TNF-α, MMP-1, MMP-2, MMP-3, MMP-9, MMP-10, and bilirubin/biliverdin were found to be significantly higher in the fractured ankles. Mean concentrations of ECM degradation markers (sGAG and CTXII) were not found to be significatnly different between groups. Conclusion: These data indicate that after intra-articular ankle fracture the SF exhibits a largely pro-inflammatory and extra-cellular matrix degrading environment similar to that described in idiopathic osteoarthritis. IL-6, IL-8, MMP-1, MMP-2, MMP-3, MMP-9, and MMP-10 were significantly elevated and may play a role in the development of PTOA. Clinical Relevance: In addition to anatomic fracture reduction, these data lend credence to reducing acute intra-articular inflammation through the development of antagonists to these pro-inflammatory and degrading mediators. Likewise, intra-articular lavage might reduce this inflammatory burden.
Antihypertensive Drugs and Male Sexual Dysfunction
Authors: Al Khaja Khalid A. J. , Sequeira Reginald P. , Alkhaja Alwaleed K. , Damanhori Awatif H. H. 
Published: October 2015

Background: Published clinical practice guidelines have addressed antihypertensive therapy and sexual dysfunction (SD) in many different ways. Objective: In this systematic review, we evaluated guidelines that address antihypertensive drug-associated SD, guideline recommendations, and recent guideline trends. Methods: Thirty sets of guidelines for hypertension management in adults that had been published in the English language since 2000 were reviewed. The primary outcome measure was antihypertensive-associated SD potential, which was independently evaluated using specific questions by 2 authors in a nonblinded standardized manner. Results: Sexual dysfunctions associated with thiazide-class diuretics, β-blockers, and centrally acting sympathoplegics were addressed by half of the guidelines reviewed. There is no clarity on β-blockers and thiazide-class diuretics because one-third of the guidelines are vague about individual β-blockers and diuretics, and there is no statement on third-generation β-blockers and thiazide-like diuretics that can improve erectile function. The revised guidelines never use terms such as loss of libido, ejaculatory dysfunction, lack of orgasm, and priapism. Summary versions of guidelines are inadequate to reflect the key interpretation of the primary guidelines on SD associated with antihypertensives, even in the major guidelines that were updated recently. Therapeutic issues such as exploring SD in clinical history, assessing SD prior to and during treatment with antihypertensives, substituting the offending agents with alternatives that possess a better safety profile, intervening with phosphodiesterase-5 inhibitors, and avoiding the concomitant use of nitrovasodilators are superficially addressed by most guidelines, with the exception of 2013 European Society of Hypertension/European Society of Cardiology and Seventh Joint National Committee recommendations. Conclusion: Future guideline revisions, including both full and summary reports, should provide a balanced perspective on antihypertensive-related SD issues to improve the impact of hypertension treatment guidelines on patient care and quality of life.
Cord blood T cells mediate enhanced antitumor effects compared with adult peripheral blood T cells
Authors: Hiwarkar Prashant , Qasim Waseem , Ricciardelli Ida , Gilmour Kimberly , Quezada Sergio , Saudemont Aurore , Amrolia Persis , Veys Paul 
Published: October 2015

Key PointsCB T cells mediate enhanced antitumor responses compared with PB T cells in a murine model of B-cell lymphoma. The antitumor activity correlates with increased tumor-homing of CCR7high CB CD8+ T cells and rapid gain of cytotoxic and Th1 function.