bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of postoperative necrotizing enterocolitis after neonatal cardiac surgery on neurodevelopmental outcome at 1 year of age
Authors: Knirsch Walter , De Silvestro Alexandra , Rathke Verena , L’Ebraly Christelle , Natterer Julia C. , Schneider Juliane , Sekarski Nicole , Latal Beatrice , Borradori-Tolsa Cristina , Bouhabib Maya S. , Fuhrer Kradolfer Katharina , Glöckler Martin , Hutter Damian , Pfluger Marc R. , Kaiser Lena , Polito Angelo , Kelly-Geyer Janet F. , von Rhein Michael ,   the Swiss ORCHID group
Published: August 2024

ObjectivesWe analyzed the impact of postoperative necrotizing enterocolitis (NEC) after cardiac surgery in neonatal age on neurodevelopmental (ND) outcome at 1 year of age.MethodsUsing data from the Swiss Neurodevelopmental Outcome Registry for Children with Congenital Heart Disease (ORCHID), we analyzed perioperative variables including postoperative NEC (Bell's stage ≥2) and 1-year ND outcome (Bayley III).ResultsThe included patients (n = 101) had congenital heart disease (CHD), categorized as follows: 77 underwent biventricular repair for CHD with two functional chambers, 22 underwent staged palliation until the Fontan procedure for CHD with single ventricle physiology (n = 22), or 4 underwent single ventricle palliation or biventricular repair for borderline CHD (n = 4). Neonatal cardiopulmonary bypass (CBP) surgery was performed at a median age (IQR) of 8 (6) days. NEC occurred in 16 patients. Intensive care unit (ICU) length of stay (LOS) and the total duration of the hospitalization were longer in children with NEC than those in others (14 with vs. 8 days without NEC, p &lt; 0.05; 49 with vs. 32 days without NEC, p &lt; 0.05). The Bayley III scores of the analyzed patients determined at an age of 11.5 ± 1.5 months showed cognitive (CCS) (102.2 ± 15.0) and language scores (LCS) (93.8 ± 13.1) in the normal range and motor composite scores (MCS) (88.7 ± 15.9) in the low-normal range. After adjusting for socioeconomic status and CHD type, patients with NEC had lower CCS scores [β = −11.2 (SE 5.6), p = 0.049]. Using a cumulative risk score including NEC, we found a higher risk score to be associated with both lower CCS [β = −2.8 (SE 1.3), p = 0.030] and lower MCS [β = −3.20 (SE 1.3), p = 0.016].ConclusionsPostoperative NEC is associated with longer ICU and hospital LOS and contributes together with other complications to impaired ND outcome at 1 year of age. In the future, national and international patient registries may provide the opportunity to analyze large cohorts and better identify the impact of modifiable perioperative risk factors on ND outcome.
Clinical Trial RegistrationClinicalTrials.gov identifier: NCT05996211.
Anomalous pulmonary venous drainage due to malposition of septum primum: two case reports and literature review
Authors: Yang Yan , Zhao Jianshe , Dong Chunhua , Yi Minggang , Gao Xin 
Published: August 2024

BackgroundAnomalous pulmonary venous connection with malposition of septum primum (MSP) is a rare pediatric cardiovascular malformation. Although reports in the literature are scarce, accurate pre-operative imaging diagnosis is crucial for selecting the appropriate clinical intervention and determining the prognosis for affected children.Case descriptionIn both case reports, the cardiovascular malformations were incidental findings. In the second case, an enlarged cardiac silhouette was observed on chest x-ray due to pneumonia, which was subsequently confirmed by ultrasound. Combined with computed tomography angiography examination, the diagnosis of MSP-type anomalous pulmonary venous connection was established.ConclusionsComprehensive imaging examinations are essential in reducing misdiagnosis and achieving an accurate diagnosis of MSP-type anomalous pulmonary venous connection. The typical imaging findings for MSP-type anomalous pulmonary venous connection include absence or hypoplasia of the superior limbic band of the septum secundum, leftward displacement of the septum primum, and partial or total pulmonary vein drainage into the anatomical right atrium.
Data mining and safety analysis of dual orexin receptor antagonists (DORAs): a real-world pharmacovigilance study based on the FAERS database
Authors: Jiang Manxue , Li Hao , Kong Lingti 
Published: August 2024

ObjectiveUsing the Food and Drug Administration Adverse Event Reporting System (FAERS) database, four signal detection methods were applied to mine adverse drug events (ADEs) related to use of dual orexin receptor antagonists (DORAs) to provide reference for safe clinical use.Research design and MethodsData collected from Q3rd 2014 to Q4th 2023 were obtained from the FAERS database. According to the preferred terminology (PT) and systematic organ classification (SOC) of MedDRA v.26.0, the reporting odds ratio (ROR), proportional reporting ratio (PRR), multi-item gamma Poisson shrinker (MGPS), and Bayesian confidence propagation neural network (BCPNN) were used to detect ADE signals.ResultsA total of 11,857 DORAs-related adverse reactions were detected, reported with suvorexant, lemborexant, and daridorexant as the main suspected drugs was 8717584, and 2556, respectively. A higher proportion of females than males were reported (57.27% vs. 33.04%). The top 20 positive PT signals from three DORAs showed that “sleep paralysis” ranked first. “Brain fog” was stronger following daridorexant but was not detected for the other two drugs, and “sleep sex” and “dyssomnia” were stronger in suvorexant but not in the other two drugs. Additionally, some PTs occurred that were not included in drug instructions, such as “hangover” and “hypnagogic hallucination.”ConclusionIn this study, four algorithms (ROR, PRR, BCPNN, and MGPS) were used to mine the safety signals of DORAs. We identified some potential ADE signals that can promote the rational use of DORAs and improve their safety.
Inertial measurement unit-based real-time feedback gait immediately changes gait parameters in older inpatients: a pilot study
Authors: Miyazaki Takasuke , Kiyama Ryoji , Takeshita Yasufumi , Shimose Daichi , Araki Sota , Matsuura Hisanori , Uto Yuki , Nakashima Shobu , Nakai Yuki , Kawada Masayuki 
Published: August 2024

The effect of gait feedback training for older people remains unclear, and such training methods have not been adapted in clinical settings. This study aimed to examine whether inertial measurement unit (IMU)-based real-time feedback gait for older inpatients immediately changes gait parameters. Seven older inpatients (mean age: 76.0 years) performed three types of 60-s gait trials with real-time feedback in each of the following categories: walking spontaneously (no feedback trial); focused on increasing the ankle plantarflexion angle during late stance (ankle trial); and focused on increasing the leg extension angle, which is defined by the location of the ankle joint relative to the hip joint in the sagittal plane, during late stance (leg trial). Tilt angles and accelerations of the pelvis and lower limb segments were measured using seven IMUs in pre- and post-feedback trials. To examine the immediate effects of IMU-based real-time feedback gait, multiple comparisons of the change in gait parameters were conducted. Real-time feedback increased gait speed, but it did not significantly differ in the control (p = 0.176), ankle (p = 0.237), and leg trials (p = 0.398). Step length was significantly increased after the ankle trial (p = 0.043, r = 0.77: large effect size). Regarding changes in gait kinematics, the leg trial increased leg extension angle compared to the no feedback trial (p = 0.048, r = 0.77: large effect size). IMU-based real-time feedback gait changed gait kinematics immediately, and this suggests the feasibility of a clinical application for overground gait training in older people.
Promoting theory of mind and emotion understanding in preschool settings: an exploratory training study
Authors: Grazzani Ilaria 
Published: August 2024

IntroductionThis new exploratory study is part of a larger ongoing follow-up project. Its specific aim was to verify whether an innovative European Program, primarily designed to enhance children’s social and emotional learning, led to gains in theory of mind and emotion understanding when implemented in preschool settings.MethodsThirty-four children (mean age: 56.4 months; SD: 10.1; range: 40–70 months) participated in the study. They were randomly and equally divided into a training group and a control group. The training sample completed eight linguistic-conversational activities drawn from the Program, in groups of 5 to 6 children, over 8 weeks. The activities were based on listening to stories and/or watching videos and then thinking and talking about the inner world (thoughts and emotions) of the story characters as well as the participants’ own inner states. During the training phase, the children in the control group engaged in drawing or free play activities. At both the pre-test and post-test phases of the study, all the children completed a language test, a battery of theory of mind (ToM) tasks (including ‘change of location’ and ‘unexpected content’ tasks), and the Test of Emotion Comprehension which evaluates nine components of emotion understanding (EU). The validated national versions of the tests were administered in all cases.ResultsSignificant differences were identified between the training and control groups. Indeed, the participants in the Program training activities, which were based on conversational exchanges between an adult and a group of children, as well as among the children themselves, outperformed the control participants on both overall theory of mind and overall emotion understanding. A more detailed analysis showed that the training group outperformed the control group in relation to both specific components of EU and the ‘change of location’ ToM task.DiscussionThe results of this exploratory study suggest that the Program is effective at enhancing preschoolers’ social understanding and thus merits implementation in preschool settings.
Duration mismatch negativity under varying deviant conditions in individuals with high schizotypal traits
Authors: Deng Jue , Zhang Yuanjun , Lu Liqin , Ou Yuanhua , Lai Xianghui , Chen Siwei , Ye Yiduo 
Published: August 2024

BackgroundAlthough impaired auditory mismatch negativity (MMN) has consistently been found in individuals with schizophrenia, there are few and inconsistent reports on nonclinical individuals with schizotypy. To date, no studies have thoroughly assessed MMN with different degrees of deviant oddballs in nonclinical schizotypal samples. The aim of this study was to examine the extent of duration MMN (dMMN) amplitudes under two deviant duration conditions (large and small) in nonclinical participants with high schizotypal traits.MethodsAn extreme-group design was utilized, in which 63 participants from the schizotypy and control groups were selected from a pool of 1519 young adults using the Schizotypal Personality Questionnaire (SPQ). MMN was measured using passive duration oddball paradigms. Basic demographic information and musical backgrounds were assessed and matched, while depression and anxiety were evaluated and controlled for. The repeated measures analysis of covariance was utilized to evaluate differences in dMMN between groups. The Bonferroni correction was applied for multiple comparisons. Partial correlation and multiple linear regression analyses were conducted to investigate the association between dMMN amplitudes and SPQ scores.ResultsThe amplitudes of dMMN at Cz were significantly increased under the large deviance condition in nonclinical schizotypal individuals (F = 4.36, p = .04). Large-deviance dMMN amplitudes at Fz were positively correlated with mild cognitive-perceptual symptoms in the control group (rp = .42, p = .03). However, as schizophrenia-like symptoms worsened and approached the clinical threshold for schizophrenia, small-deviance dMMN amplitudes at Cz showed negative associations with the cognitive-perceptual factor in the schizotypy group (rp = -.40, p = .04).ConclusionThese results suggest the importance of considering the degree of deviation in duration when implementing the auditory oddball paradigm among nonclinical participants with schizotypal traits. In addition, our findings reveal a potential non-linear relationship between bottom-up auditory processing and the positive dimension of the schizophrenia spectrum.
Illness-related variables and abnormalities of resting-state brain activity in schizophrenia
Authors: Giuliani Luigi , Pezzella Pasquale , Giordano Giulia Maria , Fazio Leonardo , Mucci Armida , Perrottelli Andrea , Blasi Giuseppe , Amore Mario , Rocca Paola , Rossi Alessandro , Bertolino Alessandro , Galderisi Silvana , Maj Mario 
Published: August 2024

BackgroundThe development of neuroimaging biomarkers in patients with schizophrenia (SCZ) requires a refined clinical characterization. A limitation of the neuroimaging literature is the partial uptake of progress in characterizing disease-related features, particularly negative symptoms (NS) and cognitive impairment (CI). In the present study, we assessed NS and CI using up-to-date instruments and investigated the associations of abnormalities in brain resting-state (rs)-activity with disease-related features.MethodsSixty-two community-dwelling SCZ subjects participated in the study. Multiple regression analyses were performed with the rs-activity of nine regions of interest as dependent variables and disease-related features as explanatory variables.ResultsAttention/vigilance deficits were negatively associated with dorsal anterior cingulate rs-activity and, together with depression, were positively associated with right dorsolateral prefrontal cortex rs-activity. These deficits and impairment of Reasoning/problem-solving, together with conceptual disorganization, were associated with right inferior parietal lobule and temporal parietal junction rs-activity. Independent of other features, the NS Expressive Deficit domain was associated with the left ventral caudate, while the Motivational Deficit was associated with the dorsal caudate rs-activity.ConclusionNeurocognitive deficits and the two negative symptom domains are associated with different neural markers. Replications of these findings could foster the identification of clinically actionable biomarkers of poor functional outcomes.
Uncovering an emerging policy direction for Australian energy and future fuels using a “participatory decision-making” framework
Authors: Kambo Amrita , Kannampuzha Leo , Arratia-Solar Andrea , Witt Katherine 
Published: August 2024

IntroductionAn online deliberative engagement process was undertaken with members of the general public to understand what they value or would like to change about the energy system, within the broader context of decarbonizing Australia's energy networks, identifying a role for future fuels (hydrogen and biogas). Citizens developed a set of principles that could guide Australia's path toward a low-carbon energy future, reflecting on expectations they place upon energy transition. Next, citizens' principles were shared with policy-makers in government and policy-influencers from the energy industry using an online interactive workshop.MethodsThis study analyses policy-makers and -influencers response to citizens' guiding principles using the 'diamond of participatory decision-making' framework for analysis. Convergence and divergence in diverse, complex and rich views across cohorts and implications thereupon energy policy were identified.ResultsAlthough considerable alignment between multi-stakeholders' views was noted, key areas of divergence, or what is called the “groan zone” were easily identified in relation to social and environmental justice issues. This groan zone highlights the struggles that energy policy-makers face -the need to listen and respond to citizens' voices, vs. the need for practical and workable policies that also support overarching government or industry objectives.DiscussionPolicy making when the views of different stakeholders align is relatively straightforward. However, this is not the case where the expectations diverge. More creative measures will be needed to address divergent views and expectations whilst maintaining procedural fairness, in this case, using democratic deliberative engagement processes. While the use of deliberative processes is gaining momentum worldwide, particularly concerning climate change and energy transition policies, this paper also highlights the benefits of conducting a robust post facto analysis of the content of the processes. Areas of alignment, where policy can be made and implemented relatively easily without contention are identified. Other areas (such as making electrification mandatory) might be more complex or have unwanted negative social and environmental justice effects. Overall, this paper bridges an analytical gap between “expectation studies” and participatory research. By borrowing terminology from a participatory research framework we sharpen the concepts in “expectation studies” from a consensus, inclusion and diversity standpoint.
Neuronavigation in glioma resection: current applications, challenges, and clinical outcomes
Authors: Sulangi Albert Joseph , Husain Adam , Lei Haoyi , Okun Jessica 
Published: August 2024

BackgroundGlioma resection aims for maximal tumor removal while preserving neurological function. Neuronavigation systems (NS), with intraoperative imaging, have revolutionized this process through precise tumor localization and detailed anatomical navigation.ObjectiveTo assess the efficacy and breadth of neuronavigation and intraoperative imaging in glioma resections, identify operational challenges, and provide educational insights to medical students and non-neurosurgeons regarding their practical applications.MethodsThis systematic review analyzed studies from 2012 to 2023 on glioma patients undergoing surgical resection with neuronavigation, sourced from MEDLINE (PubMed), Embase, and Web of Science. A database-specific search strategy was employed, with independent reviewers screening for eligibility using Rayyan and extracting data using the Joanna Briggs Institute (JBI) tool.ResultsThe integration of neuronavigation systems with intraoperative imaging modalities such as iMRI, iUS, and 5-ALA significantly enhances gross total resection (GTR) rates and extent of resection (EOR). While advanced technology improves surgical outcomes, it does not universally reduce operative times, and its impact on long-term survival varies. Combinations like NS + iMRI and NS + 5-ALA + iMRI achieve higher GTR rates compared to NS alone, indicating that advanced imaging adjuncts enhance tumor resection accuracy and success. The results underscore the multifaceted nature of successful surgical outcomes.ConclusionsIntegrating intraoperative imaging with neuronavigation improves glioma resection. Ongoing research is vital to refine technology, enhance accuracy, reduce costs, and improve training, considering various factors impacting patient survival.
Constructing and Validating Estimation Models for Individual-Tree Aboveground Biomass of Salix suchowensis in China
Authors: Fu Wei , Niu Chaoyue , Hu Chuanjing , Zhang Peiling , Chen Yingnan 
Published: August 2024

Biomass serves as a crucial indicator of plant productivity, and the development of biomass models has become an efficient way for estimating tree biomass production rapidly and accurately. This study aimed to develop a rapid and accurate model to estimate the individual aboveground biomass of Salix suchowensis. Growth parameters, including plant height (PH), ground diameter (GD), number of first branches (NFB), number of second branches (NSB) and aboveground fresh biomass weight (FW), were measured from 892 destructive sample trees. Correlation analysis indicated that GD had higher positive correlations with FW than PH, NFB and NSB. According to the biological features and field observations of S. suchowensis, the samples were classified into three categories: single-stemmed type, first-branched type and second-branched type. Based on the field measurement data, regression models were constructed separately between FW and each growth trait (PH, GD, NFB and NSB) using linear and nonlinear regression functions (linear, exponential and power). Then, multiple power regression and multiple linear regression were conducted to estimate the fresh biomass of three types of S. suchowensis. For the single-stemmed plant type, model M1 with GD as the single parameter had the highest adj R2, outperforming the other models. Among the 16 constructed biomass-estimating equations for the first-branched plant type, model M32 FW = 0.010371 × PH1.15862 × GD1.250581 × NFB0.190707 was found to have the best fit, with the highest coefficient of determination (adj R2 = 0.6627) and lowest Akaike Information Criterion (AIC = 5997.3081). When it comes to the second-branched plant type, the best-fitting equation was proved to be the multiple power model M43 with PH, GD, NFB and NSB as parameters, which had the highest adj R2 value and best-fitting effect. The stability and reliability of the models were confirmed by the F-test, repeated k-fold cross-validation and paired-sample t-tests. The models developed in this study could provide efficient tools for accurately estimating the total aboveground biomass for S. suchowensis at individual tree levels. The results of this study could also be useful for optimizing the economic productivity of shrub willow plantations.
Impact COVID-19 Pandemic towards E-Commerce Sales Value and E-Grocery Sales Value in Indonesia
Authors: Widyawan  , Soegoto H 
Published: August 2024

The positive case of COVID-19 in Indonesia was first detected on March 2, 2020, when two people were confirmed positive infected. It is impossible to avoid the economic slowdown when COVID-19 come about, apart from that there has been a shift in people's spending patterns online to adapt to the situation. After 3 year this study aims to determine impact of the COVID-19 pandemic towards e-commerce sales value and e-grocery sales value in Indonesia. This study is using an event study method (long horizon event study). The event period is divided into 2 specifically 12 and 24 month before-after the event period starting from first year COVID-19 pandemic in Indonesia. The sample was selected by using the purposive sampling method and obtained from Statista premium statistic database. The first results of this study is in 12 month before and after the event, there was no significant difference in e-commerce sales value but the opposite result was obtained from the 24 month, there were significant differences between e-commerce sales value before and after the event. The second results of this study is in 12 month before and after the event, there was no significant difference in e-grocery sales value but the opposite result was obtained from the 24 month, there were significant differences between e-grocery sales value before and after the event. The conclusion is the COVID-19 pandemic doesnt have significant effect on both variable in 12 month event but have significant effect after 24 month. The authors hope that the results of this research can be useful for the public interest, especially for accelerating economic development appropriately afterCOVID-19.