bluuebunny/crossref_metadata_2025_split huggingface dataset:
Corepressor Rcor1 is essential for murine erythropoiesis
Authors: Yao Huilan , Goldman Devorah C. , Nechiporuk Tamilla , Kawane Sunita , McWeeney Shannon K. , Tyner Jeffrey W. , Fan Guang , Kerenyi Marc A. , Orkin Stuart H. , Fleming William H. , Mandel Gail 
Published: March 2014

Key PointsRcor1 knockout mice show a block in fetal erythropoiesis at the proerythroblast stage. Rcor1 represses expression of HSCs and myeloid genes during erythropoiesis, including Csf2rb, which is important in myeloid function.
Nordic MCL3 study: 90Y-ibritumomab-tiuxetan added to BEAM/C in non-CR patients before transplant in mantle cell lymphoma
Authors: Kolstad Arne , Laurell Anna , Jerkeman Mats , Grønbæk Kirsten , Elonen Erkki , Räty Riikka , Pedersen Lone Bredo , Loft Annika , Bogsrud Trond Velde , Kimby Eva , Hansen Per Boye , Fagerli Unn-Merete , Nilsson-Ehle Herman , Lauritzsen Grete Fossum , Lehmann Anne Kristine , Sundstrom Christer , Karjalainen-Lindsberg Marja-Liisa , Ralfkiaer Elisabeth , Ehinger Mats , Delabie Jan , Bentzen Hans , Schildt Jukka , Kostova-Aherdan Kamelia , Frederiksen Henrik , Brown Peter de Nully , Geisler Christian H. 
Published: March 2014

Key PointsZ-BEAM/C did not improve outcome for patients in only PR or CRu before transplant. Positive PET before transplant and MRD after transplant predicted inferior PFS and OS.
Outcome of patients with abnl(17p) acute myeloid leukemia after allogeneic hematopoietic stem cell transplantation
Authors: Middeke Jan M. , Fang Min , Cornelissen Jan J. , Mohr Brigitte , Appelbaum Frederick R. , Stadler Michael , Sanz Jaime , Baurmann Herrad , Bug Gesine , Schäfer-Eckart Kerstin , Hegenbart Ute , Bochtler Tilmann , Röllig Christoph , Stölzel Friedrich , Walter Roland B. , Ehninger Gerhard , Bornhäuser Martin , Löwenberg Bob , Schetelig Johannes 
Published: March 2014

Key Points
Patients with abnl(17p) AML have a poor outcome after allogeneic hematopoietic stem cell transplantation.
Major adverse cardiovascular events in adult congenital heart disease: a population-based follow-up study from Taiwan
Authors: Lin Yu-Sheng , Liu Pi-Hua , Wu Lung-Sheng , Chen Yu-Ming , Chang Chee-Jen , Chu Pao-Hsien 
Published: March 2014

Abstract

Background
The aim of the present study was to identify the long-term major adverse cardiovascular events (MACE) in adult congenital heart disease (ConHD) patients in Taiwan.

Methods
From the National Health Insurance Research Database (1997-2010), adult patients (≥18 years) with ConHD were identified and compared to non-ConHD control patients. The primary end point was the incidence of MACE. Cox proportional hazards models were used to compute hazard ratios as estimates for multivariate adjusted relative risks with or without adjusting for age and sex.

Results
A total of 3,267 adult patients with ConHD were identified between 2000 and 2003 with a median follow-up of 11 years till December 31, 2010. The five most common types of ConHD were atrial septal defects, ventricular septal defects, patent ductus arteriosus, tetralogy of Fallot, and pulmonary stenosis. Overall, the incidence of MACE was 4.0-fold higher in the ConHD group compared with the controls. After adjustment for age and gender, the patients with ConHD had an increased risk of heart failure, malignant dysrhythmia, acute coronary syndrome, and stroke. The adult ConHD patients had a decreased life-long risk of MACE if they received surgical correction, especially in the patients with atrial septal defects.

Conclusions
After a median of 11 years of follow-up, the Taiwanese patients with ConHD were at an increased risk of life-long cardiovascular MACE, including heart failure, stroke, acute coronary syndrome, and malignant dysrhythmia. Surgical correction may help to decrease long-term MACE in ConHD patients, especially those with ASD.
Treatment of hemolymphangioma of the spleen by laparoscopic partial splenectomy: a case report
Authors: Zhang Yue , Chen Xue-Min , Sun Dong-Lin , Yang Chun 
Published: March 2014

AbstractHemolymphangioma is a malformation of both lymphatic and blood vessels. The incidence of splenic hemolymphangioma is extremely rare. Laparoscopic partial splenectomy is feasible, reproducible, and safe in children with focal splenic tumors. We report on the case of a 12-year-old male with a large splenic hemolymphangioma successfully managed by laparoscopic partial splenectomy. The patient recovered well after operation. Laparoscopic partial splenectomy is a safe and minimally invasive technique for treatment of splenic hemolymphangioma located in the pole of the spleen.
Electrical and optical properties of binary CN
x
nanocone arrays synthesized by plasma-assisted reaction deposition
Authors: Liu Xujun , Guan Leilei , Fu Xiaoniu , Zhao Yu , Wu Jiada , Xu Ning 
Published: March 2014

Abstract
Light-absorbing and electrically conductive binary CN
x
nanocone (CNNC) arrays have been fabricated using a glow discharge plasma-assisted reaction deposition method. The intact CNNCs with amorphous structure and central nickel-filled pipelines could be vertically and neatly grown on nickel-covered substrates according to the catalyst-leading mode. The morphologies and composition of the as-grown CNNC arrays can be well controlled by regulating the methane/nitrogen mixture inlet ratio, and their optical absorption and resistivity strongly depend on their morphologies and composition. Beside large specific surface area, the as-grown CNNC arrays demonstrate high wideband absorption, good conduction, and nice wettability to polymer absorbers.
A novel lithium/sulfur battery based on sulfur/graphene nanosheet composite cathode and gel polymer electrolyte
Authors: Zhang Yongguang , Zhao Yan , Bakenov Zhumabay 
Published: March 2014

Abstract
A novel sulfur/graphene nanosheet (S/GNS) composite was prepared via a simple ball milling of sulfur with commercial multi-layer graphene nanosheet, followed by a heat treatment. High-resolution transmission and scanning electronic microscopy observations showed the formation of irregularly interlaced nanosheet-like structure consisting of graphene with uniform sulfur coating on its surface. The electrochemical properties of the resulting composite cathode were investigated in a lithium cell with a gel polymer electrolyte (GPE) prepared by trapping 1 mol dm−3 solution of lithium bistrifluoromethanesulfonamide in tetraethylene glycol dimethyl ether in a polymer matrix composed of poly(vinylidene fluoride-co-hexafluoropropylene)/poly(methylmethacrylate)/silicon dioxide (PVDF-HFP/PMMA/SiO2). The GPE battery delivered reversible discharge capacities of 809 and 413 mAh g−1 at the 1st and 50th cycles at 0.2C, respectively, along with a high coulombic efficiency over 50 cycles. This performance enhancement of the cell was attributed to the suppression of the polysulfide shuttle effect by a collective effect of S/GNS composite cathode and GPE, providing a higher sulfur utilization.
High levels of anxiety and depression in diabetic patients with Charcot foot
Authors: Chapman Zahra , Shuttleworth Charles Matthew James , Huber Jörg Wolfgang 
Published: March 2014

AbstractBackground/aimsCharcot foot is a rare but devastating complication of diabetes. Little research is available on the mental health impact of Charcot foot. Aim of the study is to assess mental health in diabetes patients with Charcot foot and to investigate the moderating effects of socio‐demographic factors. The severity of the problem will be statistically evaluated with the help of a reference data set.MethodsCross‐sectional questionnaire data using the Hospital Anxiety and Depression Scale (HADS) and demographic background were collected from 50 patients with diabetes and Charcot complications (males 62%; mean age 62.2 ± 8.5 years). Statistical comparisons with a large data set of general diabetes patients acting as a point of reference were carried out.ResultsAnxiety and depression levels were high, (anxiety and depression scores 6.4 ± 4 and 6.3 ± 3.6 respectively). Females reported more severe anxiety and depression. Ethnic minorities and patients out of work reported more severe anxiety. Comparisons with published HADS data indicate that diabetes patients with Charcot foot experience more serious levels of anxiety and depression.ConclusionsThe high levels of mental health problems which were found in this study in diabetes patients with Charcot foot require recognition by researchers and clinicians. The findings imply the need to screen for mental health problems in diabetes patients with Charcot foot.
Biopsy confirmation of metastatic sites in breast cancer patients: clinical impact and future perspectives
Authors: Criscitiello Carmen , André Fabrice , Thompson Alastair M , De Laurentiis Michele , Esposito Angela , Gelao Lucia , Fumagalli Luca , Locatelli Marzia , Minchella Ida , Orsi Franco , Goldhirsch Aron , Curigliano Giuseppe 
Published: March 2014

AbstractDetermination of hormone receptor (estrogen receptor and progesterone receptor) and human epidermal growth factor receptor 2 status in the primary tumor is clinically relevant to define breast cancer subtypes, clinical outcome, and the choice of therapy. Retrospective and prospective studies suggest that there is substantial discordance in receptor status between primary and recurrent breast cancer. Despite this evidence and current recommendations, the acquisition of tissue from metastatic deposits is not routine practice. As a consequence, therapeutic decisions for treatment in the metastatic setting are based on the features of the primary tumor. Reasons for this attitude include the invasiveness of the procedure and the unreliable outcome of biopsy, in particular for biopsies of lesions at complex visceral sites. Improvements in interventional radiology techniques mean that most metastatic sites are now accessible by minimally invasive methods, including surgery. In our opinion, since biopsies are diagnostic and changes in biological features between the primary and secondary tumors can occur, the routine biopsy of metastatic disease needs to be performed. In this review, we discuss the rationale for biopsy of suspected breast cancer metastases, review issues and caveats surrounding discordance of biomarker status between primary and metastatic tumors, and provide insights for deciding when to perform biopsy of suspected metastases and which one (s) to biopsy. We also speculate on the future translational implications for biopsy of suspected metastatic lesions in the context of clinical trials and the establishment of bio-banks of biopsy material taken from metastatic sites. We believe that such bio-banks will be important for exploring mechanisms of metastasis. In the future, advances in targeted therapy will depend on the availability of metastatic tissue.
Absence of strong strain effects in behavioral analyses ofShank3-deficient mice
Authors: Drapeau Elodie , Dorr Nate P. , Elder Gregory A. , Buxbaum Joseph D. 
Published: March 2014

AbstractHaploinsufficiency of SHANK3, caused by chromosomal abnormalities or mutations that disrupt one copy of the gene, leads to a neurodevelopmental syndrome called Phelan-McDermid Syndrome that can include absent or delayed speech, intellectual disability, neurological changes, and autism spectrum disorders. The SHANK3 protein forms a key structural part of the post-synaptic density. We previously generated and characterized mice with a targeted disruption of Shank3 in which exons coding for the ankyrin repeat domain were deleted and expression of full-length Shank3 was disrupted. We documented specific deficits in synaptic function and plasticity, along with reduced reciprocal social interactions in Shank3 heterozygous mice. Changes in phenotype due to a mutation at a single locus are quite frequently modulated by other loci, most dramatically when the entire genetic background is changed. In mice, each strain of laboratory mouse represents a distinct genetic background and alterations in phenotype due to gene knockout or transgenesis are frequently different across strains, which can lead to the identification of important modifier loci. We have investigated the effect of genetic background on phenotypes of Shank3-heterozygous, knock-out and wild-type mice, using C57BL/6, 129SVE, and FVB/Ntac strain backgrounds. We focused on observable behaviors with the goal of carrying out subsequent analyses to identify modifier loci. Surprisingly, there were very modest strain effects over a large battery of analyses. These results indicate that behavioral phenotypes associated with Shank3 haploinsufficiency are largely strain independent.
Heme acts through the Bach1b/Nrf2a-MafK pathway to regulate exocrine peptidase precursor genes in porphyric zebrafish
Authors: Zhang Shuqing , Xu Minrui , Huang Jian , Tang Lili , Zhang Yanqing , Wu Jingyao , Lin Shuo , Wang Han 
Published: March 2014

Abstract
Using a zebrafish model for hepatoerythropoietic porphyria (HEP), we found a new mechanism underlying heme regulation of exocrine zymogens. Zebrafish bach1b, nrf2a and mafK are all expressed in the zebrafish exocrine pancreas. Overexpression of bach1b and knockdown of nrf2a result in downregulation of the zymogens, whereas overexpression of nrf2a and knockdown of bach1b cause their upregulation. In vitro luciferase assays demonstrated that heme activates the zymogens in a dosage-dependent manner, and the zymogens promoter activities require the integral MARE (Maf Recognition Element) motif. The Bach1b:MafK heterodimer represses the zymogens, whilst the Nrf2a:MafK heterodimer activates them. Furthermore, chromatin immunoprecipitation (ChIP) assays showed that MafK binds the MARE sites in the 5'; regulatory regions of the zymogens, heme triggers replacing Bach1b with Nrf2a within the MafK-occupied MARE sites in the regulatory regions of the zymogens, and particularly in heme-deficient porphyria, the repressing Bach1b:MafK heterodimer dominates, which can be switched to the activating Nrf2a:MafK heterodimer by hemin treatment. These results provide novel insights into regulation of exocrine function as well as the pathogenesis of porphyria, and should be useful for designing therapies for diseases of both categories.
Histopathology reveals correlative and unique phenotypes in a high throughput mouse phenotyping screen
Authors: Adissu Hibret A. , Estabel Jeanne , Sunter David , Tuck Elizabeth , Hooks Yvette , Carragher Damian M. , Clarke Kay , Karp Natasha A. , Wellcome Trust Sanger Institute Sanger Mouse Genetics Project , Newbigging Susan , Jones Nora , Morikawa Lily , White Jacqui K. , McKerlie Colin 
Published: March 2014

Abstract
The Mouse Genetics Project (MGP) at the Wellcome Trust Sanger Institute aims to generate and phenotype over 800 genetically modified mouse lines over the next 5 years to gain a better understanding of mammalian gene function, and provide an invaluable resource to the scientific community for follow up studies. Phenotyping includes generation of a standardized biobank of paraffin embedded tissues for each mouse line, but histopathology is not routinely performed. In collaboration with the Pathology Core of the Centre for Modeling Human Disease (CMHD) we report the utility of histopathology in a high-throughput primary phenotyping screen. Histopathology was assessed in an unbiased selection of 50 mouse lines with (n=30) or without (n=20) clinical phenotypes detected by the standard MGP primary phenotyping screen. Our findings revealed that histopathology added correlating morphological data in 19 of 30 lines (63.3%) in which the primary screen detected a phenotype. In addition, 7 of the 50 lines (14%) presented significant histopathology findings that were not associated with or predicted by the standard primary screen. Three of these 7 lines had no clinical phenotype detected by the standard primary screen. Incidental and strain-associated background lesions were present in all mutant lines with good concordance to wild type controls. These findings demonstrate the complementary and unique contribution of histopathology to high throughput primary phenotyping of mutant mice.
Understanding and Managing Intravenous Container Overfill; Potential Dose Confusion
Authors: Cohen Michael R. , Smetzer Judy L. 
Published: March 2014

These medication errors have occurred in health care facilities at least once. They will happen again—perhaps where you work. Through education and alertness of personnel and procedural safeguards, they can be avoided. You should consider publishing accounts of errors in your newsletters and/or presenting them at your inservice training programs. Your assistance is required to continue this feature. The reports described here were received through the Institute for Safe Medication Practices (ISMP) Medication Errors Reporting Program. Any reports published by ISMP will be anonymous. Comments are also invited; the writers’ names will be published if desired. ISMP may be contacted at the address shown below. Errors, close calls, or hazardous conditions may be reported directly to ISMP through the ISMP Web site ( www.ismp.org ), by calling 800-FAIL-SAFE, or via e-mail at ismpinfo@ismp.org . ISMP guarantees the confidentiality and security of the information received and respects reporters’ wishes as to the level of detail included in publications.
Extended Stability of Intravenous 0.9% Sodium Chloride Solution after Prolonged Heating or Cooling
Authors: Puertos Enrique 
Published: March 2014

Purpose The primary objective of this study was to evaluate the stability and sterility of an intravenous 0.9% sodium chloride solution that had been cooled or heated for an extended period of time. Methods Fifteen sterile 1 L bags of 0.9% sodium chloride solution were randomly selected for this experiment. Five bags were refrigerated at an average temperature of 5.2°C, 5 bags were heated at an average temperature of 39.2°C, and 5 bags were stored at an average room temperature of 21.8°C to serve as controls. All samples were protected from light and stored for a period of 199 days prior to being assayed and analyzed for microbial and fungal growth. Results There was no clinically significant difference in the mean sodium values between the refrigerated samples, the heated samples, and the control group. There were no signs of microbial or fungal growth for the duration of the study. Conclusion A sterile intravenous solution of 0.9% sodium chloride that was heated or cooled remained stable and showed no signs of microbial or fungal growth for a period of 199 days. This finding will allow hospitals and emergency medical technicians to significantly extend the expiration date assigned to these fluids and therefore obviate the need to change out these fluids every 28 days as recommended by the manufacturer.
Occurrence of the genus Tolypiocladia F. Schmitz (Rhodomelaceae, Rhodophyta) in the Atlantic Ocean
Authors: de Castro Nunes José Marcos , de Jesus Priscila Barreto , Caires Taiara Aguiar , de Beauclair Guimarães Silvia Maria Pita 
Published: March 2014

Abstract
A survey of Rhodophyta on the coast of Bahia state, northeast Brazil, revealed new records for the occurrence of a red alga. The specimens were identified as Tolypiocladia glomerulata. We describe the morphological characters of this species and compare them with literature reports of other species belonging to the genus. This is the first record of the genus Tolypiocladia from the Atlantic Ocean.
Big denominators and analytic normal forms
Authors: Stolovitch Laurent 
Published: March 2014

Abstract

We study the regular action of an analytic pseudo-group of transformations on the space of germs of various analytic objects of local analysis and local differential geometry. We fix a homogeneous object F
0 and we are interested in an analytic normal form for the whole affine space

{

F
0

+
h.o.t.
}

${\lbrace F_0 + \text{h.o.t.}\rbrace }$

. We prove that if the cohomological operator defined by F
0 has the big denominators property and if a formal normal form is well chosen, then this formal normal form holds in analytic category.
We also define big denominators in systems of nonlinear PDEs and prove a theorem on local analytic solvability of systems of nonlinear PDEs with big denominators.
Moreover, we prove that if the denominators grow “relatively fast”, but not fast enough to satisfy the big
denominators property, then we have a normal form, respectively local solvability of PDEs, in a formal Gevrey category. We illustrate our theorems by explanation of known results and by new results in the problems of local classification of singularities
of vector fields, non-isolated singularities of functions, tuples of germs of vector fields, local Riemannian metrics and conformal structures.
Multivariate Fractional Regression Estimation of Econometric Share Models
Authors: Mullahy John 
Published: March 2014

Abstract
This paper describes and applies econometric strategies for estimating regression models of economic share data outcomes where the shares may take boundary values (zero and 1) with nontrivial probability. The main focus of the paper is on the conditional mean structures of such data. The paper proposes an extension of the fractional regression methodology proposed by (Papke, L. E., and J. M. Wooldridge. 1996. “Econometric Methods for Fractional Response Variables with an Application to 401(k) Plan Participation Rates.” Journal of Applied Econometrics 11: 619–632; Papke, L. E. and J. M. Wooldridge. 2008. “Panel Data Methods for Fractional Response Variables with an Application to Test Pass Rates.” Journal of Econometrics 145: 121–133.), in univariate cross-sectional and panel contexts. The paper discusses the stochastic aspects of share definition and measurement, and summarizes important features of the existing literature on econometric strategies for share model estimation. The paper then goes on to discuss the univariate fractional regression estimation strategies proposed by Papke and Wooldridge and to extend the fractional regression approach to estimation of and inference about regression models describing the multivariate share data. Some issues involving outcome aggregation/disaggregation are considered, as is a full likelihood estimation approach based on Dirichlet-multinomial models. The paper demonstrates the workings of these various empirical strategies by estimating models of financial asset portfolio shares using data from the 2001, 2004, and 2007 US Surveys of Consumer Finances.
Singular value decomposition for the cone-beam transform in the ball
Authors: Kazantsev Sergey G. 
Published: March 2014

Abstract
The X-ray computerized tomography is concerned to the reconstruction of a function
f from line (ray) integrals of f. In general, we may have the
parallel ray or divergent ray geometry.
In this paper we develop an analytical singular value decomposition method
for the cone-beam transform in divergent ray geometry.
For the parallel ray transform a singular value decomposition has been derived
by P. Maass in 1987.
Solution to the inverse Wulff problem by means of the enhanced semidefinite relaxation method
Authors: Ševčovič Daniel , Trnovská Mária 
Published: March 2014

Abstract
We propose a novel method of resolving the optimal anisotropy function. The idea is to construct the optimal anisotropy function as a
solution to the inverse Wulff problem, i.e. as a minimizer for the anisoperimetric ratio for a given Jordan curve in the plane. It leads to a nonconvex quadratic optimization problem with linear matrix inequalities. In order to solve it we propose the so-called enhanced semidefinite relaxation method which is based on a solution to a convex semidefinite problem obtained by a semidefinite relaxation of the original problem augmented by quadratic-linear constraints. We show that the sequence of finite-dimensional approximations of the optimal anisoperimetric ratio converges to the optimal anisoperimetric ratio which is a solution to the inverse Wulff problem. Several computational examples, including those corresponding to boundaries of real snowflakes, and discussion on the rate of convergence of numerical method are also presented in this paper.