bluuebunny/crossref_metadata_2025_split huggingface dataset:
Bevacizumab Erlotinib Switch Maintenance in Chemo-Responsive Advanced Gallbladder and Cholangiocarcinoma (BEER BTC): A Multicenter, Open-Label, Randomized, Phase II Trial
Authors: Ramaswamy Anant , Bhargava Prabhat , Srinivas Sujay , Kapoor Akhil , Mishra Bal Krishna , Gupta Anuj , Mandavkar Sarika , Kannan Sadhana , Chaugule Deepali , Patil Rajshree , Parulekar Manali , Nashikkar Chaitali , Ankathi Suman Kumar , Kaushal Rajiv Kumar , Naughane Deepali , Daddi Anuprita , Mer Neha , Shetty Nitin , Ostwal Vikas 
Published: August 2024

PURPOSE Patients with chemotherapy-responsive advanced biliary tract cancers (BTCs) are usually observed after 6 months of gemcitabine-based therapy. There is limited prospective evidence for maintenance strategies after chemotherapy. METHODS This investigator-initiated, open-label, randomized, integrated phase II-III study enrolled adult patients with advanced BTC from two cancer centers in India. Patients with histologically confirmed advanced biliary tract adenocarcinoma who had at least disease stabilization after 6 months of gemcitabine-based chemotherapy were randomly assigned (1:1) to either active surveillance or switch maintenance, which was a combination of bevacizumab 5 mg/kg intravenous once every 21 days plus erlotinib 100 mg once daily. Both arms were continued until disease progression, unacceptable toxicity, or patient decision to withdraw. The primary end point of the phase II component of the trial was investigator-evaluated progression-free survival. This trial is registered with Clinical Trials Registry of India (CTRI/2019/05/019323I). RESULTS From May 2021 to November 2022, 98 patients were randomly assigned to active surveillance (n = 49) or bevacizumab-erlotinib (n = 49). A majority of patients had gallbladder cancer (80%). The median follow-up was 13.4 months. The median progression-free survival was 3.1 months (95% CI, 2.47 to 3.64) in the active surveillance group versus 5.3 months (95% CI, 3.53 to 7.04) in the bevacizumab-erlotinib group (hazard ratio, 0.51 [95% CI, 0.33 to 0·74]; P = .0013). The most common grade 3 class-specific adverse events associated with bevacizumab-erlotinib were acneiform rash 1 (2%) and oral stomatitis 1 (2%) with erlotinib and bleeding 1 (2%) with bevacizumab. CONCLUSION The combination of bevacizumab and erlotinib as switch maintenance improves progression-free survival with an acceptable safety profile compared with active surveillance in patients with advanced BTCs in this phase II study. The trial moves on to the phase III component to evaluate improvement in overall survival.
Impact of Age on Pharmacogenomics and Treatment Outcomes of B-Cell Acute Lymphoblastic Leukemia
Authors: Yoshimura Satoshi , Li Zhenhua , Gocho Yoshihiro , Yang Wenjian , Crews Kristine R. , Lee Shawn H.R. , Roberts Kathryn G. , Mullighan Charles G. , Relling Mary V. , Yu Jiyang , Yeoh Allen E.J. , Loh Mignon L. , Saygin Caner , Litzow Mark R. , Jeha Sima , Karol Seth E. , Inaba Hiroto , Pui Ching-Hon , Konopleva Marina , Jain Nitin , Stock Wendy , Paietta Elisabeth , Jabbour Elias , Kornblau Steven M. , Evans William E. , Yang Jun J. 
Published: August 2024

PURPOSE
Acute lymphoblastic leukemia (ALL) can occur across all age groups, with a strikingly higher cure rate in children compared with adults. However, the pharmacological basis of age-related differences in ALL treatment response remains unclear.

METHODS
Studying 767 children and 309 adults with newly diagnosed B-cell ALL enrolled on frontline trials at St Jude Children's Research Hospital, MD Anderson Cancer Center, the Alliance for Clinical Trials in Oncology, and the ECOG-ACRIN Cancer Research Group, we determined the ex vivo sensitivity of leukemia cells to 21 drugs. Twenty-three ALL molecular subtypes were identified using RNA sequencing. We systematically characterized the associations between drug response and ALL genomics in children, adolescents and young adults, and elderly adults. We evaluated the effect of age-related gene expression signature on ALL treatment outcomes.

RESULTS

Seven ALL drugs (asparaginase, prednisolone, mercaptopurine, dasatinib, nelarabine, daunorubicin, and inotuzumab ozogamicin) showed differential activity between children and adults, of which six were explained by age-related differences in leukemia molecular subtypes. Adolescents and young adults showed similar patterns of drug resistance as older adults, relative to young children. Mercaptopurine exhibited subtype-independent greater sensitivity in children. Transcriptomic profiling uncovered subclusters within
CRLF2
-,
DUX4
-, and
KMT2A
-rearranged ALL that were linked to age and cytotoxic drug resistance. In particular, a subset of children had adult-like ALL on the basis of leukemia gene expression patterns across subtypes, despite their chronological age. Resistant to cytotoxic drugs, children with adult-like ALL exhibited poor prognosis in pediatric ALL trials, even after adjusting for age and minimal residual diseases.

CONCLUSION
Our results provide pharmacogenomic insights into age-related disparities in ALL cure rates and identify leukemia prognostic features for treatment individualization across age groups.
Murmurs of Presence in Objects of Absence
Authors: Feldman Ilana 
Published: August 2024

Abstract
This article takes two artifacts belonging to two people the author met in the course of many decades of research in and on Palestine—a British Mandate-era identity card and a set of framed photographs of a Palestinian village destroyed in the Nakba (catastrophe) of 1948—as central objects of consideration in reflecting on how objects of absence incorporate historical and personal loss as well as continuing presence. The use of the term “objects of absence” to describe these materials points to how they are more than repositories of memory. They record, preserve, and animate forms of life that appear lost. Rather than being noisy eruptions into public life, their volume is more of a murmur. Their collective impact is in their repeated presence rather than their spectacular pronouncements. Palestinians preserve these objects for themselves, for their children and following generations, for their community, and for their nation. The work of these objects is thus personal and political, individual and collective. They help people locate themselves in the world, maintaining some continuity despite the devastation of the Nakba.
Open-source, high-throughput targeted in situ transcriptomics for developmental and tissue biology
Authors: Lee Hower , Langseth Christoffer Mattsson , Salas Sergio Marco , Sariyar Sanem , Metousis Andreas , Rueda-Alaña Eneritz , Bekiari Christina , Lundberg Emma , Garcı́a-Moreno Fernando , Grillo Marco , Nilsson Mats 
Published: August 2024

ABSTRACT
Multiplexed spatial profiling of mRNAs has recently gained traction as a tool to explore the cellular diversity and the architecture of tissues. We propose a sensitive, open-source, simple and flexible method for the generation of in situ expression maps of hundreds of genes. We use direct ligation of padlock probes on mRNAs, coupled with rolling circle amplification and hybridization-based in situ combinatorial barcoding, to achieve high detection efficiency, high-throughput and large multiplexing. We validate the method across a number of species and show its use in combination with orthogonal methods such as antibody staining, highlighting its potential value for developmental and tissue biology studies. Finally, we provide an end-to-end computational workflow that covers the steps of probe design, image processing, data extraction, cell segmentation, clustering and annotation of cell types. By enabling easier access to high-throughput spatially resolved transcriptomics, we hope to encourage a diversity of applications and the exploration of a wide range of biological questions.
Can a Supplier’s Yield Risk Be Truthfully Communicated via Cheap Talk?
Authors: Lu Tao 
Published: August 2024

Problem definition: When a firm (buyer) outsources the production of a new product/component to a supplier subject to random yield, a major challenge is that the supplier’s yield is usually private information. In practice, yield information is often shared via nonbinding communication—for example, a supplier self-assessment report. We examine whether such communication can be truthful and credible. Methodology/results: We analyze a cheap-talk game in which, given a simple contract that specifies the prices for each unit ordered and for each effective unit delivered, the supplier first communicates its yield level, and then the buyer determines an order quantity. We prove that truthful communication can emerge in equilibrium. To do so, we first show that if knowing the supplier’s type, the buyer will either inflate or reduce the order quantity to cope with a lower yield, depending on the product’s market potential. Under asymmetric information, the supplier will truthfully communicate its type if (i) the buyer with a high market potential intends to inflate the order quantity for a lower yield, but the buyer with a low market potential prefers to do the reverse; and (ii) the supplier is uncertain about the product’s market potential, which is the buyer’s private information, and anticipates that a hard-to-make product is more likely to have a higher market potential. Managerial implications: Truthful cheap-talk communication can emerge in equilibrium when the product’s market size and yield are negatively correlated. Truthful communication always benefits the buyer and consumers and may benefit the supplier if the product has sufficient market potential and the supplier’s production cost is not too high. Moreover, the buyer can be better off paying more for the input quantity (although part of the output is defective) or paying a higher wholesale rate if the adjustment in payment terms enhances communication credibility. Supplemental Material: The online appendix is available at https://doi.org/10.1287/msom.2023.0089 .
Syphilis should not be overlooked in any individual, irrespective of their condition
Authors: Cellier Oriane , Jourdan Juliette , Dahmane Lotfi , Perronne Véronique , Dinh Aurélien , Jaffal Karim 
Published: August 2024

Introduction: Syphilis remains a significant challenge in public health, largely because of its diverse clinical manifestations, often resulting in underdiagnosis especially among patients with neurogenic disability. Case description: We present a case of neurosyphilis in a 63-year-old patient with a spinal cord injury. Despite syphilis being a well-established sexually transmitted infection, the exacerbation of neurological and dermatological symptoms during physical examination prompted an investigation into alternative causes beyond the patient’s pre-existing paraparesis, ultimately resulting in the diagnosis of neurosyphilis. Conclusion: This case highlights the importance of considering syphilis as a potential diagnosis in individuals regardless of their medical history.
Time to treatment of first-episode psychosis: the role of early intervention teams
Authors: Hall Michael , Mills Rachel , Watson Edward , Nathan Rajan , Stewart Alex G 
Published: August 2024

Background/Aims Psychosis can affect a person's functioning, quality of life and physical health. Early intervention for service users presenting with psychosis has been implemented via early intervention teams, but there are inconsistencies in assessment and treatment. The aim of this study was to examine time to treatment (defined as the commencement of antipsychotic medication) for service users experiencing first-episode psychosis, the impact of this and engagement with teams. The authors explored the effect of patient characteristics (eg gender, deprivation, ethnicity, age) and early intervention teams on time to treatment for psychosis. Methods A retrospective cohort study was undertaken using routine data of service users accessing three early intervention teams from 2018–19. The care records of 457 service users were examined, including patient characteristics, assessments, time to first contact, treatment and time to discharge. Data were analysed using the Statistical Package for Social Sciences. Results Use of the Positive and Negative Syndrome Scale assessment tool differed across the three early intervention teams. Engagement with all teams varied by gender. Men were particularly slow to access treatment in one team (118 of 163 service users, 72.4%). Conclusions Increased emphasis on engaging male patients may improve service delivery. Improved communication between early intervention teams could increase standardisation of assessment and treatment.
Intracavity-pumped, noncritical CdSe OPO operating at 100  Hz
Authors: Wang Li , Chen Weidong , Divliansky Ivan B. , Pasiskevicius Valdas , Mhibik Oussama , Moelster Kjell M. , Zukauskas Andrius , Petrov Valentin 
Published: August 2024

Spectral narrowing of the first stage signal wave in a cascade optical parametric oscillator (OPO) using a volume Bragg grating produced narrowband ∼0.6-mJ idler pulses at 9.245 µm from the second stage based on CdSe at a repetition rate of 100 Hz. The CdSe crystal is pumped intracavity by the signal wave from the periodically poled KTiOPO4 based first stage, and both stages operate under noncritical phase-matching conditions. The ∼8-ns-long mid-IR output pulses have a spectral bandwidth of 8.4cm−1. An overall quantum conversion efficiency of 14.2% from 1.064 µm is achieved with a simple, compact, and robust all-solid-state design.
Felix Klein aus der Sicht der drei mathematischen Freunde
Authors: Hänel Jule , Oswald Nicola , Steuding Jörn , Volkert Klaus 
Published: August 2024

ZusammenfassungIn diesem Artikel geht es um das Bild, das die drei mathematischen Freunde Hilbert, Hurwitz und Minkowski in ihrer Korrespondenz von Felix Klein entwerfen.
Endomyocardial involvement in asymptomatic Latin American migrants with eosinophilia related to helminth infection: A pilot study
Authors: Sempere Abiu , Salvador Fernando , Milà Laia , Casas Guillem , Durà-Miralles Xavier , Sulleiro Elena , Vila-Olives Rosa , Bosch-Nicolau Pau , Aznar Maria Luisa , Espinosa-Pereiro Juan , Treviño Begoña , Sánchez-Montalvá Adrián , Serre-Delcor Núria , Oliveira-Souto Inés , Pou Diana , Rodríguez-Palomares José , Molina Israel 
Published: August 2024

Background
Hypereosinophilic syndrome can produce cardiac involvement and endomyocardial fibrosis, which have a poor prognosis. However, there is limited information regarding cardiac involvement among migrants from Latin America with eosinophilia related to helminthiasis.

Methods
We conducted a pilot observational study where an echocardiography was performed on migrants from Latin America with both eosinophilia (>450 cells/μL) and a diagnosis of helminth infection, and on migrants from Latin America without eosinophilia or helminth infection. Microbiological techniques included a stool microscopic examination using the Ritchie’s formalin-ether technique, and a specific serology to detect Strongyloides stercoralis antibodies.

Results
37 participants were included, 20 with eosinophilia and 17 without eosinophilia. Twenty (54.1%) were men with a mean age of 41.3 (SD 14.3) years. Helminthic infections diagnosed in the group with eosinophilia were: 17 cases of S. stercoralis infection, 1 case of hookworm infection, and 2 cases of S. stercoralis and hookworm coinfection. Among participants with eosinophilia, echocardiographic findings revealed a greater right ventricle thickness (p = 0.001) and left atrial area and volume index (p = 0.003 and p = 0.004, respectively), while showing a lower left atrial strain (p = 0.006) and E-wave deceleration time (p = 0.008). An increase was shown in both posterior and anterior mitral leaflet thickness (p = 0.0014 and p = 0.004, respectively) when compared with participants without eosinophilia.

Conclusions
Migrants from Latin America with eosinophilia related to helminthic infections might present incipient echocardiographic alterations suggestive of early diastolic dysfunction, that could be related to eosinophilia-induced changes in the endomyocardium.
Incidence and risk factors of SARS-CoV-2 breakthrough infection in the early Omicron variant era among vaccinated and boosted individuals in Chicago
Authors: Moreno Echevarria Fabiola , Caputo Mathew , Camp Daniel , Reddy Susheel , Achenbach Chad J. 
Published: August 2024

Background
SARS-CoV-2 vaccines are safe and effective against infection and severe COVID-19 disease worldwide. Certain co-morbid conditions cause immune dysfunction and may reduce immune response to vaccination. In contrast, those with co-morbidities may practice infection prevention strategies. Thus, the real-world clinical impact of co-morbidities on SARS-CoV-2 infection in the recent post-vaccination period is not well established. This study was performed to understand the epidemiology of Omicron breakthrough infection and evaluate associations with number of comorbidities in a vaccinated and boosted population.

Methods and findings
A retrospective clinical cohort study was performed utilizing the Northwestern Medicine Enterprise Data Warehouse. Our study population was identified as fully vaccinated adults with at least one booster. The primary risk factor of interest was the number of co-morbidities. The primary outcome was the incidence and time to the first positive SARS-CoV-2 molecular test in the Omicron predominant era. Multivariable Cox modeling analyses to determine the hazard of SARS-CoV-2 infection were stratified by calendar time (Period 1: January 1 –June 30, 2022; Period 2: July 1 –December 31, 2022) due to violations in the proportional hazards assumption. In total, 133,191 patients were analyzed. During Period 1, having 3+ comorbidities was associated with increased hazard for breakthrough (HR = 1.16 CI 1.08–1.26). During Period 2 of the study, having 2 comorbidities (HR = 1.45 95% CI 1.26–1.67) and having 3+ comorbidities (HR 1.73, 95% CI 1.51–1.97) were associated with increased hazard for Omicron breakthrough. Older age was associated with decreased hazard in Period 1 of follow-up. Interaction terms for calendar time indicated significant changes in hazard for many factors between the first and second halves of the follow-up period.

Conclusions
Omicron breakthrough is common with significantly higher risk for our most vulnerable patients with multiple co-morbidities. Age plays an important role in breakthrough infection with the highest incidence among young adults, which may be due to age-related behavioral factors. These findings reflect real-world differences in immunity and exposure risk behaviors for populations vulnerable to COVID-19.
Late Presentation of Recurrent Solid Pseudopapillary Pancreatic Neoplasm With Liver Metastases During Pregnancy
Authors: Chaudhary Ammad Javaid , Jamali Taher , Dababneh Yara , Saleem Abdulmalik , Salgia Reena 
Published: August 2024

ABSTRACT
Our case highlights a rare instance of recurrent metastatic solid pseudopapillary epithelial neoplasms of the pancreas, emerging 8 years after radical pancreatic resection—an extended interval surpassing the reported average. Managing solid pseudopapillary epithelial neoplasm during pregnancy is uniquely challenging, given the increase in the expression of progesterone receptors during the intrapartum period, leading to tumor growth. Although surgical resection remains the primary approach, systemic chemotherapy, radiation therapy, and liver transplant are other considerations. The absence of consensus guidelines for recurrence monitoring emphasizes the need for vigilant, long-term surveillance extending beyond the conventional 5-year mark.
DH Lab@Philosophenturm – Digital Humanities und Lab-Kultur als infrastrukturelle Herausforderung
Authors: Müller-Laackman Jonas 
Published: August 2024

Zusammenfassung
Mit der Einrichtung des DH Labs im sogenannten Philosophenturm der Universität Hamburg hat die Universität Hamburg in Zusammenarbeit mit der Bibliothek für Geisteswissenschaften und der Staats- und Universitätsbibliothek Hamburg einen Ort für Digital Humanities Praxis geschaffen. Dabei waren im Vorfeld wie in der Umsetzung verschiedene Herausforderungen zu bewältigen und Bedarfe zu adressieren. Der Artikel diskutiert die Idee und Umsetzbarkeit eines Digital Humanities Labs als Ort für freie Experimentalkultur von unten am Fallbeispiel der Universität Hamburg.
Applicability of the External Genitalia Score (EGS) in Indian neonates and children up to 2 years of age
Authors: Nanda Pamali Mahasweta , Yadav Jaivinder , Dayal Devi , Kumar Rakesh , Kumar Praveen , Kumar Jogender , Kaur Harvinder , Sikka Pooja 
Published: August 2024

Abstract

Objectives
To generate normative data and validate the recently developed, gender-neutral, External Genitalia Score (EGS) in Indian preterm and term neonates and children up to 2 years of age with normal and atypical genitalia.

Methods
This observational study included 1,040 neonates born between 28 and 42 weeks of gestation and 152 children between 1 and 24 months of age. In addition, 50 children with disorders of sex development (DSD) were also enrolled in the study. The Prader stage/external masculinization score (EMS) (as applicable), anogenital ratio (AGR) and EGS were assessed for all neonates and children with typical and atypical genitalia.

Results
Median EGS values in newborn males with typical genitalia were 9.5 at 28–31 weeks, 10.5 at 32–33 weeks, 11 at 34 weeks and 11.5 in males at 35–42 weeks of gestation. For all females with typical genitalia, the EGS was 0. EMS and EGS showed a positive correlation in males with typical genitalia (r=0.421, p=0.000**) and all children with DSD (r=0.857, p=0.000**). Mean AGR in males and females with typical genitalia and those with DSD were 0.52±0.07, 0.31±0.05 and 0.47±0.13, respectively. EGS correlated with AGR in all males with typical genitalia (r=0.107, p=0.008**), and in all children with DSD (r=0.473, p=0.001**).

Conclusions
The EGS enables accurate, gender-neutral and comprehensive assessment of external genitalia in Indian neonates and children with typical and atypical genitalia/DSD. Evaluation for DSD is recommended in any child with EGS greater than 0 and ≤10th percentile for gestation or age (10.5 in a term neonate).
New perspectives for the treatment and follow-up of glycogen storage disease type V: DL-3-hydroxybutyric acid with modified Atkins diet and quadriceps femoris shear wave elastography
Authors: Özsaydı Aktaşoğlu Ekin , Kılıç Ayşe , Emecen Şanlı Merve , İnci Aslı , Aktaş Emine , Akdulum İsmail , Yaylı Nezih , Okur İlyas , Ezgü Fatih Süheyl , Tümer Leyla 
Published: August 2024

Abstract

Objectives
Glycogen storage disease type V is caused by the mutations in muscle glycogen phosphorylase gene. This is the first report which DL-3-hydroxybutyric acid was used in combination with modified Atkins diet for the treatment of a patient with glycogen storage disease type V and quadriceps femoris shear wave elastography was performed to evaluate the treatment efficacy.

Case presentation
A 13-year-old girl was referred with fatigue and muscle cramps with exercise and there were no pathological findings in physical examination. Creatine kinase levels with 442 U/L. No phosphorylase enzyme activity was detected in muscle biopsy, a homozygous c.1A>G (p.M1V) pathogenic mutation was found in PYGM gene. She was started on DL-3-hydroxybutyric acid and modified Atkins diet at age 16. Her walking and stair climbing capacity increased, the need for rest during exercise decreased. The stiffness of the quadriceps femoris exhibited a reduction.

Conclusions
DL-3-hydroxybutyric acid and modified Atkins diet may provide an alternative fuel and shear wave elastography may be useful in demonstrating treatment efficacy. More clinical and pre-clinical studies are obviously needed to reach more definite conclusions.