bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nonspecific labeling limits the utility of Cre‐Lox bred CST‐YFP mice for studies of corticospinal tract regeneration
Authors: Willenberg Rafer , Steward Oswald 
Published: May 2015

ABSTRACTStudies of axon regeneration in the spinal cord often assess regeneration of the corticospinal tract (CST). Emx1‐Cre x Thy1‐STOP‐YFP mice have been reported to have yellow fluorescent protein (YFP) selectively expressed in forebrain neurons leading to genetic labeling of CST axons in the spinal cord, and it was suggested that these CST‐YFP mice would be useful for studies of CST regeneration. Because regeneration past a lesion may involve only a few axons, the presence of labeled non‐CST axons compromises interpretation. We show here that in CST‐YFP mice, some YFP‐labeled axons are not from the CST. Specifically, YFP‐labeled axons are present in regions beyond those with anterogradely labeled CST axons, most YFP‐labeled axons beyond established CST locations do not undergo Wallerian degeneration following a large lesion of the sensorimotor cortex, some rubrospinal and reticulospinal neurons are labeled with YFP, and some YFP‐labeled cells in the spinal gray matter have YFP‐labeled projections into the spinal cord white matter. We further demonstrate that the density of YFP‐labeled axon arbors hinders tracing of single axons to their point of origin in the main descending tracts. In light of recent advances in 3D imaging for visualizing axons in unsectioned blocks of spinal cord, we also assessed CST‐YFP mice for 3D imaging and found that YFP fluorescence in CST‐YFP mice is faint for clearing‐based 3D imaging in comparison with fluorescence in Thy1‐YFP‐H mice and fluorescence of mini‐ruby biotinylated dextran amine (BDA). Overall, the nonspecific and faint YFP labeling in CST‐YFP mice limits their utility for assessments of CST axon regeneration. J. Comp. Neurol. 523:2665–2682, 2015. © 2015 Wiley Periodicals, Inc.
Differential distribution of GABA and glycine terminals in the inferior colliculus of rat and mouse
Authors: Choy Buentello David , Bishop Deborah C. , Oliver Douglas L. 
Published: May 2015

ABSTRACTThe inferior colliculus (IC), the midbrain component of the auditory pathway, integrates virtually all inputs from the auditory brainstem. These are a mixture of excitatory and inhibitory ascending inputs, and the inhibitory transmitters include both gamma‐aminobutyric acid (GABA) and glycine (GLY). Although the presence of these inhibitory inputs is well established, their relative location in the IC is not, and there is little information on the mouse. Here, we study the distribution of glutamic acid decarboxylase (GAD)67 and GLY transporter 2 (T2) in axonal terminals to better understand the relative contributions of these inputs. Large‐scale mosaic composite images of immunohistochemistry sections of rat and mice were used to isolate the signals related to the concentrations of these axonal terminals in the tissue, and the ratio of GLYT2/GAD67 in each pixel was calculated. GLYT2 was seen only in the central nucleus of the IC (ICC), whereas GAD67 was seen throughout the IC. The map of the GAD67 and GLYT2 axonal distribution revealed a gradient that runs from ventrolateral to dorsomedial along the axis of the laminae of the ICC and perpendicular to the tonotopic axis. Although anatomically different, both the mouse and the rat had relatively more GAD67 dorsomedially in the ICC and relatively more GLYT2 ventrolaterally. This organization of GABA and GLY inputs may be related to functional zones with different properties in ICC that are based, in part, on different sets of inhibitory inputs to each zone. J. Comp. Neurol. 523:2683–2697, 2015. © 2015 Wiley Periodicals, Inc.
Childhood social inequalities influences neural processes in young adult caregiving
Authors: Kim Pilyoung , Ho Shaun S. , Evans Gary W. , Liberzon Israel , Swain James E. 
Published: May 2015

ABSTRACTChildhood poverty is associated with harsh parenting with a risk of transmission to the next generation. This prospective study examined the relations between childhood poverty and non‐parent adults' neural responses to infant cry sounds. While no main effects of poverty were revealed in contrasts of infant cry versus acoustically matched white noise, a gender by childhood poverty interaction emerged. In females, childhood poverty was associated with increased neural activations in the posterior insula, striatum, calcarine sulcus, hippocampus, and fusiform gyrus, while, in males, childhood poverty was associated with reduced levels of neural responses to infant cry in the same regions. Irrespective of gender, neural activation in these regions was associated with higher levels of annoyance with the cry sound and reduced desire to approach the crying infant. The findings suggest gender differences in neural and emotional responses to infant cry sounds among young adults growing up in poverty. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 948–960, 2015.
Early developmental stress negatively affects neuronal recruitment to avian song system nucleusHVC
Authors: Honarmand Mariam , Thompson Christopher K. , Schatton Adriana , Kipper Silke , Scharff Constance 
Published: May 2015

ABSTRACTAdverse environmental conditions can impact the life history trajectory of animals. Adaptive responses enable individuals to cope with unfavorable conditions, but altered metabolism and resource allocation can bear long‐term costs. In songbirds, early developmental stress can cause lifelong changes in learned song, a culturally transmitted trait, and nestlings experiencing developmental stress develop smaller song control nucleus HVCs. We investigated whether nutrition‐related developmental stress impacts neurogenesis in HVC, which may explain how poor nutrition leads to smaller HVC volume. We provided different quality diets (LOW and HIGH) by varying the husks‐to‐seeds ratio to zebra finch families for the first 35 days after the young hatched (PHD). At PHD14–18 and again at nutritional independence (PHD35), juveniles were injected with different cell division markers. To monitor growth, we took body measures at PHD10, 17, and 35. At PHD35 the number of newly recruited neurons in HVC and the rate of proliferation in the adjacent ventricular zone (VZ) were counted. Males raised on the LOW diet for their first weeks of life had significantly fewer new neurons in HVC than males raised on the HIGH diet. At the time when these new HVC neurons were born and labeled in the VZ (PHD17) the birds exposed to the LOW diet had significantly lower body mass. At PHD35 body mass or neuronal proliferation no longer differed. Our study shows that even transitory developmental stress can have negative consequences on the cellular processes underlying the development of neural circuits. © 2015 Wiley Periodicals, Inc. Develop Neurobiol 76: 107–118, 2016
Frontiers in real‐time ecohydrology – a paradigm shift in understanding complex environmental systems
Authors: Krause Stefan , Lewandowski Jörg , Dahm Clifford N. , Tockner Klement 
Published: May 2015

AbstractTechnological advances in environmental sensing have increased our awareness of the complexity of spatial patterns and temporal dynamics of ecohydrological processes and their interactions. Improving the basis of knowledge of dynamically interacting processes is crucial for advancing our understanding of how ecosystems function under the influence of, and their resilience to, environmental change. Capturing the often fast changing and nonlinear behaviour of ecosystems represents a challenge for current observational networks, particularly when studying system interfaces and coupled ecological, hydrological, geomorphological and biogeochemical processes, demanding novel, adaptive approaches in real‐time monitoring and research. This paper discusses conceptual, technological and methodological challenges and resulting requirements for real‐time ecohydrological research by reviewing current approaches of capturing nonlinear behaviour with high‐frequency, high‐resolution monitoring and develops strategies for transforming ecohydrological research by including real‐time analysis of highly dynamic processes that are currently understudied. Examples of highly dynamic processes include rapid system changes, hot spots and hot moment behaviour. Copyright © 2015 John Wiley & Sons, Ltd.
Lithium‐Filled Double‐Deck Layered Structure of the RELixCu2–yP2 (RE = La, Pr, Nd, Gd, Er; 0.82 ≤ x ≤ 1; 1.19 ≤ y ≤ 1.54) Series: Experimental and Theoretical Studies
Authors: Jang Eunyoung , Nam Gnu , Woo Hyein , Lee Junseong , Han Mi‐Kyung , Kim Sung‐Jin , You Tae‐Soo 
Published: May 2015

AbstractFive rare‐earth metal containing quaternary phosphides in the RELixCu2–yP2 (RE = La, Pr, Nd, Gd, Er; 0.82 ≤ x ≤ 1; 1.19 ≤ y ≤ 1.54) series were synthesized by using high‐temperature synthetic methods, and they were characterized by single‐crystal X‐ray diffraction. The title compounds crystallize in the trigonal space group P$\bar {3}$m1 (Z = 1, Pearson code hP6) with four crystallographically independent atomic positions. The overall crystal structure can be described as a “Li‐filled” CaAl2Si2‐type structure, in which a partially occupied Li site is embedded within the “double‐deck” layers formed by two anionic components. Tight‐binding linear muffin‐tin orbital calculations including density of states, crystal orbital Hamilton population, and electron localization function analyses provided rationales for the overall electronic structure and chemical bonding of the title phase. PrLi0.98(5)Cu1.54(1)P2 indicated an antiferromagnetic interaction of Pr at a relatively low temperature with a paramagnetic Curie temperature of –6.8 K and a thermal conductivity of 3.2 W mK–1 at 323 K.
A Concise and Efficient Total Synthesis of Militarinone D
Authors: Dash Uttam , Sengupta Sandip , Sim Taebo 
Published: May 2015

AbstractA highly stereoselective, concise (14 steps longest linear sequence and 20 steps overall), and efficient (15 % overall yield) synthesis of militarinone D has been accomplished. The key reactions utilized in the sequence are enzymatic desymmetrization, cis/trans isomerization, Horner–Wadsworth–Emmons olefination, and addition of an organolithium species to a highly conjugated chiral aldehyde. The simplicity of the strategy may enable its utilization in the large‐scale production of this target. Moreover, the strategy utilized to design the route should be applicable to the preparation of analogs that bear a variety of substituted pyridinone core structures.
A Carbohydrate Approach for the First Total Synthesis of Cochliomycin C: Stereoselective Total Synthesis of Paecilomycin E, Paecilomycin F and 6′‐epi‐Cochliomycin C
Authors: Mahankali Bakkolla , Srihari Pabbaraja 
Published: May 2015

AbstractThe first total synthesis of the chlorinated resorcylic acid lactone cochliomycin C is achieved starting from the readily available sugar D‐lyxose. The strategy has also lead to the total synthesis of natural resorcylic acid lactones paecilomycin E, paecilomycin F and a synthetic analogue 6‐epi‐cochliomycin C. The key reactions include Ohira–Bestmann alkynylation, ring closing metathesis and regioselective methylation under Mitsunobu conditions.
Functionalization of a Pyridine Framework through Intramolecular Reissert–Henze Reaction of N‐(Carbamoyloxy)pyridinium Salts and Unexpected Insertion of Ethereal Solvents
Authors: Asahara Haruyasu , Kataoka Asuka , Hirao Shotaro , Nishiwaki Nagatoshi 
Published: May 2015

AbstractA new strategy for synthesis of the 2‐pyridyl carbamates is reported. This strategy exploits a new intramolecular transformation of an acyloxy group from N‐carbamoyloxypyridinium salts (Reissert–Henze‐type reaction) as the key step. Addition of a silver salt effectively accelerates the intramolecular attack of the carbonyl oxygen at the 2‐position of the pyridine ring. Additionally, a new rearrangement of the acyloxy group, combined with insertion of an ethereal solvent to give pyridine derivatives having a coordinating tether, is reported.
Total Synthesis of Isodesmosine by Stepwise, Regioselective Negishi and Sonogashira Cross‐Coupling Reactions
Authors: Koseki Yohei , Sugimura Takanori , Ogawa Keita , Suzuki Rina , Yamada Haruka , Suzuki Noriyuki , Masuyama Yoshiro , Lin Yong Y. , Usuki Toyonobu 
Published: May 2015

AbstractIsodesmosine is a crosslinking pyridinium amino acid of elastin and is an attractive biomarker for the diagnosis of chronic obstructive pulmonary disease (COPD). In this paper, we describe the total synthesis of isodesmosine. The key features of this synthesis are stepwise and regioselective palladium‐catalyzed Negishi and Sonogashira cross‐coupling reactions for efficient introduction of amino acid segments on the pyridine ring.
Annulated N‐Heterocycles by Tandem Gold(I)‐Catalyzed [3,3]‐Rearrangement/Nazarov Reaction of Propargylic Ester Derivatives: an Experimental and Computational Study
Authors: Petrović Martina , Scarpi Dina , Fiser Béla , Gómez‐Bengoa Enrique , Occhiato Ernesto G. 
Published: May 2015

AbstractThe gold(I)‐catalyzed tandem rearrangement/Nazarov reaction of propargylic ester derivatives is a useful strategy for the synthesis of cyclopenta‐fused N‐heterocyclic structures present in many natural compounds. Readily available lactams are converted into enol phosphates and triflates and coupled to propargyl alcohols under Sonogashira conditions. After acetylation, the gold‐catalyzed rearrangement of the enynyl acetates readily occurs when using 3–5 mol‐% of a gold(I) catalyst. The rearrangement generates a divinyl cation which undergoes a 4π electrocyclization (Nazarov reaction) leading to the target compound in good to excellent yield. This process has been studied in details both experimentally and computationally to understand the influence of both the reaction conditions and substrate structural features on the reaction rate and regioselectivity, as well as the torquoselectivity in the ring closure step. A series of examples illustrates at the end the scope of the reaction.
Forgive them for I have sinned: The relationship between guilt and forgiveness of others' transgressions
Authors: Jordan Jennifer , Flynn Francis J. , Cohen Taya R. 
Published: May 2015

AbstractWe propose that guilt leads to forgiveness of others' transgressions. In Study 1, people prone to experience guilt (but not shame) were also prone to forgive others for past misdeeds. In Study 2, we manipulated harm‐ and inequity‐based guilt; both increased forgiveness of others' transgressions. Further, the effect of guilt on forgiveness was mediated by identification with the transgressor. In Study 3, we replicated the guilt–forgiveness relationship and examined three other plausible mediators: capability for similar wrongdoing, empathic understanding, and general identification; only identification with the transgressor satisfied the criteria for mediation. In Study 4, we induced guilt by asking participants to harm a friend or stranger. Guilt induced by harming a friend led to greater forgiveness of third‐party transgressors, and again, identification with the transgressor mediated the effect. We discuss the implications of these results for understanding how the prosocial effects of guilt extend beyond the boundaries of a single interpersonal relationship.
Goal projection in public places
Authors: Naju Ahn Janet , Oettingen Gabriele , Gollwitzer Peter M. 
Published: May 2015

AbstractThree studies investigated the phenomenon of goal projection in everyday life considering three moderators: goal commitment, the perceived similarity of the target person, and goal attainment. Moviegoers' (Study 1) highly committed to see a particular movie projected this goal onto other movie patrons. Commuters (Study 2) highly committed to catch a certain train projected this goal onto other commuters, given that these commuters were perceived as similar. Shoppers (Study 3) projected buying a particular item when both their goal commitment and the perceived similarity of another shopper were high, and the goal was not yet attained. The results imply that goal projection is part of our everyday life and is fostered by high‐goal commitment, perceiving others as similar, and ongoing goal striving.
Bad habit or social good? How perceptions of gossiper morality are related to gossip content
Authors: Peters Kim , Kashima Yoshihisa 
Published: May 2015

AbstractFrom a folk perspective, gossipers (individuals who talk about the behaviours of others) are considered to be immoral individuals, doing harm to those they discuss. However, this folk perspective sits uneasily with recent claims that gossipers may actually do some good. In particular, it has been suggested that gossipers who share diagnostic information about the morality of social targets may help audiences to identify targets who are trustworthy and those who are not. In this way, gossipers may help audiences adaptively regulate their relationships. In this paper, we examined whether audience perceptions of gossiper morality are influenced by their perceptions that the content of gossip is able to help them regulate their relationships. Participants in two scenario studies and a realistic interaction study were presented with gossip items drawn from a pool of 24 unique behavioural descriptions and asked to rate their perceptions of the gossiper and the content of the gossip item. As predicted, participants perceived gossipers as more moral when gossipers shared the diagnostic morality gossip that participants perceived to serve relationship regulatory functions.
Optimal iSINR‐based power control for cognitive satellite terrestrial networks
Authors: Vassaki Stavroula , Poulakis Marios I. , Panagopoulos Athanasios D. 
Published: May 2015

AbstractThe incorporation of cognitive radio techniques in satellite communications has recently become a significant research challenge leading to the proposal of a novel network infrastructure known as cognitive satellite terrestrial networks. However, efficient resource management mechanisms should be proposed to provide a complete system analysis for this promising architecture. Towards this direction, this article focuses on the problem of power management in cognitive satellite terrestrial systems, where the satellite system has the role of the cognitive system, while the terrestrial represents the primary one. Particularly, a power control scheme for the satellite terminal is proposed. Taking into account the peculiarities of both systems and considering the uplink case, the goal of the proposed scheme is to optimise the performance of the satellite link without deteriorating the communication quality of the terrestrial link. To safeguard the communication of the terrestrial system, we introduce a novel interference‐based constraint, which ensures a specific level for the inverse signal‐to‐interference plus noise ratio of the terrestrial link. Both the cases of perfect and imperfect channel estimation of terrestrial link are considered in order to study a more realistic scenario. Furthermore, for the imperfect case, a protection mechanism is proposed to guarantee the communication quality of the primary link that offsets the uncertainty of channel estimation. Simulation results evaluate the performance of the proposed scheme for various system parameters and verify its superiority compared with the well‐known water‐filling based power control scheme for both cases of perfect and imperfect channel estimation. Copyright © 2015 John Wiley & Sons, Ltd.
Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells
Authors: Dhumale Suhashini S. , Waghela Bhargav N. , Pathak Chandramani 
Published: May 2015

AbstractThe receptor for advanced glycation end‐products (RAGE) is a multiligand member of the immunoglobulin superfamily, which plays an important role in maintaining cellular homeostasis. It is normally expressed on immune cells, including macrophages, monocytes, dendritic cells and T cells to maintain homeostasis, but highly upregulated at sites of vascular pathology. Accumulating evidence suggest that the elevated expression of RAGE and its ligand HMGB‐1 was found in various types of cancer. The accumulation of RAGE and its ligand high‐mobility group box proteins‐1 (HMGB1) activates complex signaling network for cell survival and evades apoptosis. Therefore, targeting the RAGE‐mediated signaling could be the promising strategies for the therapeutic potential of cancer. This study was aimed to examine the biological potential of quercetin on the regulation of RAGE‐ and HMGB1‐mediated activation of NF‐κB and induction of apoptotic cell death in MCF‐7 cells. Our findings demonstrate that quercetin inhibits the expression of RAGE and HMGB1 in MCF‐7 cells. In addition, quercetin protects necrotic insult and augments apoptosis in MCF‐7 cells. Taken together, these results suggest that quercetin plays an important role in modulating RAGE and HMGB1 signaling and induces apoptotic cell death in MCF‐7 cells. © 2015 IUBMB Life, 2015 67(5):361–373, 2015
Toxicological effects of pet food ingredients on canine bone marrow‐derived mesenchymal stem cells and enterocyte‐like cells
Authors: Ortega M. T. , Jeffery B. , Riviere J. E. , Monteiro‐Riviere N. A. 
Published: May 2015

AbstractWe developed anin vitromethod to assess pet food ingredients safety. Canine bone marrow‐derived mesenchymal stem cells (BMSC) were differentiated into enterocyte‐like cells (ELC) to assess toxicity in cells representing similar patterns of exposurein vivo. The toxicological profile of clove leave oil, eugenol, guanosine monophosphate (GMP), GMP + inosine monophosphate, sorbose, ginger root extract, cinnamon bark oil, cinnamaldehyde, thyme oil, thymol and citric acid was assessed in BMSC and ELC. The LC50for GMP + inosine monophosphate was 59.42 ± 0.90 and 56.7 ± 3.5 mg ml–1for BMSC and ELC; 56.84 ± 0.95 and 53.66 ± 1.36 mg ml–1for GMP; 0.02 ± 0.001 and 1.25 ± 0.47 mg ml–1for citric acid; 0.077 ± 0.002 and 0.037 ± 0.01 mg ml–1for cinnamaldehyde; 0.002 ± 0.0001 and 0.002 ± 0.0008 mg ml–1for thymol; 0.080 ± 0.003 and 0.059 ± 0.001 mg ml–1for thyme oil; 0.111 ± 0.002 and 0.054 ± 0.01 mg ml–1for cinnamon bark oil; 0.119 ± 0.0004 and 0.099 ± 0.011 mg ml–1for clove leave oil; 0.04 ± 0.001 and 0.028 ± 0.002 mg ml–1for eugenol; 2.80 ± 0.11 and 1.75 ± 0.51 mg ml–1for ginger root extract; > 200 and 116.78 ± 7.35 mg ml–1for sorbose. Lemon grass oil was evaluated at 0.003–0.9 in BMSC and .03‐0.9 mg ml–1in ELC and its mechanistic effect was investigated. The gene toxicology studies showed regulation of 61% genes in CYP450 pathway, 37% in cholestasis and 33% in immunotoxicity pathways for BMSC. For ELC, 80% for heat shock response, 69% for beta‐oxidation and 65% for mitochondrial energy metabolism. In conclusion, these studies provide a baseline against which differential toxicity of dietary feed ingredients can be assessedin vitrofor direct effects on canine cells and demonstrate differential toxicity in differentiated cells that represent gastrointestinal epithelial cells. Copyright © 2015 John Wiley & Sons, Ltd.