bluuebunny/crossref_metadata_2025_split huggingface dataset:
The role of human papillomavirus in laryngeal cancer and recurrent respiratory papillomatosis: epidemiological and clinical aspects
Authors: Kholopov D. V. , Lyalina L. V. , Topuzov E. Е. , Alekseeva D. A. 
Published: August 2024

In the recent decade, the number of laryngeal cancer cases increased worldwide by 23 %. Currently, laryngeal cancer morbidity and associated mortality do not show statistically significant trends toward a decrease. The main risk factors for laryngeal carcinoma are smoking, alcohol consumption, human papilloma virus (HPV) infection, recurrent respiratory papillomatosis, and genetic predisposition.Aim. To evaluate the incidence and role of HPV in etiology and clinical course of laryngeal cancer and recurrent respiratory papillomatosis.Analysis of the available literature sources published in the Medline, Pubmed, and eLibrary databases was performed. The review is based on 59 of 584 identified scientific studies. Frequency of HPV detection in laryngeal cancer tumor tissue varies and is associated with the studied country’s geographical location. The incidence of these viruses in tumor tissue varies between 2.7 and 62.6 %. Genotype 16 human papilloma virus is more common in women between the ages of 31 and 40 years and is mostly located near the glottic aperture. Genotype 6 and 11 human papilloma viruses promote development of recurrent respiratory papillomatosis of the larynx and are detected in 0–87.5 % of cases. It is noted that in patients with HPV-positive neoplasms of the larynx, better response to radiation therapy and higher survival rates are observed compared to patients without the virus. In countries where national programs of vaccination against HPV infection have been implemented, a significant decrease in the incidence of recurrent respiratory papillomatosis is observed.The incidence of HPV in laryngeal cancer and recurrent respiratory papillomatosis varies. The role of these viruses in carcinogenesis has not yet been fully understood. Clinical course of HPV-associated laryngeal carcinoma is more favorable than HPV-free laryngeal carcinoma, however, this statement requires further confirmation. Evaluation of the results of programs of vaccination against HPV and their effect on recurrent respiratory papillomatosis and laryngeal cancer morbidity is important.
Observation and treatment of patients with progressive metastatic differentiated thyroid cancer after establishment of radioiodine refractoriness
Authors: Borodavina E. V. , Kutukova S.  I. , Shurinov A. Yu. , Vasil’eva E. B. , Guz A. O. , Grishkevich I. V. , Karateeva S. D. , Shakhmatova A. R. , Slobodyanskiy R. S. , Romanchuk O. V. , Mukhitova M. R. , Karpovich M. P. , Dmitriev S. P. , Saypeeva O. S. , Tolpeykina K. A. , Tolstov S. S. , Makarova A. V. , Tyugina Ya. A. , Ovchinnikova E. G. 
Published: August 2024

Differentiated thyroid cancer is one of the most common malignant diseases of the endocrine system. Usually, it responds well to the standard treatment (surgery + radioiodine therapy), especially at early stages. During both treatment and dynamic observation, distant metastases are detected in 10–15 % of patients. In these cases, the patients continue treatment with radioactive iodine. If tumor cells have insufficient ability to capture and retain 131I or completely lose this ability, the effect of radioiodine therapy becomes limited and the disease progresses during therapy which leads to 5–10 % decrease in 10-year survival. The main problem in treatment of differentiated thyroid cancer is communication between radiologists in centers performing radioiodine therapy and clinical oncologists performing surgeries and observation at patient’s place of residence. For both specialists, the main goal is to identify clinical situations where early and effective treatment intervention can be beneficial without the risk of overdiagnosis and excessive treatment.The article considers common questions arising during multidisciplinary interactions with radiologists of radioiodine centers and presents concise guidelines on the observation and treatment procedures for patients with differentiated thyroid cancer.
Overview Sociology of Law and Positive Law to Diversion Internal Joint Property Marriage
Authors: Wafa' Zenassa'dy  , Rahayu Hartini  
Published: August 2024

Study this background because many case shape transition right on treasure together no involve from one party good party husband nor wife . circumstances above give birth to problem law new that is related with how view sociology laws and regulations applicable law to diversion treasure together in marriage so creation justice in society . Diversion treasure together according to Article 35 paragraph (1) Constitution Number 1 year 1974, husband or wife could Act on agreement second split party . By therefore if wrong one party divert treasure together must with agreement or permission from husband nor wife especially first . Purpose from study he hoped Public capable implementing the transition process treasure together corresponding with Applicable law . Study this use method study qualitative through studies References or library research . With using primary data in the form of Applicable laws and cases similar to what happens in the environment society .
A N-ACETILCISTEÍNA NA REDUÇÃO DA BUSCA POR NICOTINA EM HUMANOS E ROEDORES: UMA REVISÃO SISTEMÁTICA
Authors: Souza Alves da Silva Ingrid Thayanne , De Andrade Tenorio Cavalcanti Camilla , Souza Ferreira Amanda Gabriela , Marques Coutinho Mateus , Machado Alonso de Araújo Maria Clara , Thorpe Nunes Mendonça Pedro Gabriell , Dos Santos Souza Baracho Ester Fernanda , Barros Gonçalves da Silva Caio Victor , Henrique Campello de Freitas Saulo , Raposo de Lima Lívia Milena , Serafim da Silva Lopes Isvânia Maria 
Published: August 2024

INTRODUÇÃO: A nicotina reforça o comportamento de fumar, provocando efeitos que fomentam acentuada morbidade ao longo da vida. A N-acetilcisteína é um derivado sintético do aminoácido L-cisteína, que caracteriza uma nova abordagem farmacoterapêutica para atenuar o desejo e a recaída, entretanto, ainda não há um consenso acerca da eficácia da NAC na redução da busca por nicotina. OBJETIVO: O presente estudo visa identificar e reunir evidências recentes sobre os efeitos da N-acetilcisteína na redução da busca por nicotina em humanos e roedores. MÉTODOS: Foi realizada uma revisão sistemática da literatura acerca da associação entre a N-Acetilcisteína e a redução da busca por nicotina em humanos e roedores. Foram utilizados os descritores “N-Acetylcysteine”, “Nicotine” e “Seeking Behavior”, mediante o operador booleano “AND” . Após a aplicação dos critérios de inclusão e exclusão foram selecionados sete artigos, para a realização do estudo. RESULTADOS: Os estudos incluídos em modelos animais demonstram que o NAC pode ter efeitos positivos, dependentes de fatores como duração do tratamento, na redução do comportamento de busca por nicotina; outros estudos clínicos não conseguiram demonstrar benefícios significativos na redução da busca por nicotina em fumantes humanos. CONCLUSÃO: A eficácia do NAC parece depender da duração do tratamento e das doses administradas em ratos e humanos e, também, da combinação com terapias comportamentais em humanos.
O PAPEL DAS GALECTINAS NA INFLAMAÇÃO E MIELINIZAÇÃO EM DISFUNÇÕES COGNITIVAS DE DISTÚRBIOS NEUROLÓGICOS
Authors: Cavalcante Muniz Gomes Celina , Germano Crispim Joelson , Gabriel Menezes Bezerra Ykaro , Sibelly Pereira de Lima Viviane , Melgarejo da Rosa Michelle 
Published: August 2024

Distúrbios neurológicos (DNs) têm crescido junto ao envelhecimento e aumento populacional global, sendo um desafio ao sistema de saúde pública. DNs envolvem disfunções sinápticas e moleculares que comprometem a cognição, memória e aprendizado. As galectinas (gal) são potenciais moduladoras da neuroinflamação, com expressão neurológica. Assim, tem-se como objetivo entender a associação entre as galectinas, vias moleculares e celulares na fisiopatologia de DNs. Realizou-se uma revisão narrativa nas bases de dados Pubmed, LILACS e Scielo, com as palavras-chave em inglês e português “galectins” and “cognition”. 23 estudos in vivo, in vitro e post-mortem foram incluídos nesta revisão. Na Doença de Alzheimer (DA), isquemia/reperfusão renal (IR), HIV, malária cerebral e esquizofrenia, diversos estudos mostraram relação entre expressão significativa aumentada ou reduzida da gal-3, gal-9, gal-8 e gal-1 e marcadores pró-inflamatórios e anti-inflamatórios, neurodegenerativos e sinápticos. Na DA, apneia obstrutiva do sono e IR, o silenciamento ou inibição farmacológica da gal-3 atenuou a neuroinflamação e apoptose neuronal, gerou proteção contra neurotoxicidade e melhorou o comprometimento cognitivo. Na isquemia a administração de gal-3 gerou remielinização e atenuação de déficits cognitivos. Concluiu-se que as galectinas –1, –3, -4, -8 e –9 modulam processos neuroinflamatórios e neurodegenerativos presentes em disfunções cognitivas de DNs, sendo potenciais alvos terapêuticos.
Palavras-chave: galectinas; cognição; neurofisiologia; inflamação; mielina.
Experimental Study of a Temperature Field in a Shut-in Well in Relation to Determining Behind-the-Casing Flow Using Active Thermometry
Authors: Valiullin R.A. , Ramazanov A.Sh. , Sharafutdinov R.F. , Kosmylin D.V. , Davletshin F.F. , Akchurin R.Z. 
Published: August 2024

Abstract
—This paper presents results of experimental studies of a thermal field in the barrel of a shut-in (no fluid movement in the casing) well in relation to determining a behind-the-casing upward flow using the method of active thermometry. The studies are carried out using the physical model of a well that is a vertically oriented steel pipe with a system of externally attached copper tubes simulating a behind-the-casing flow. The pipe contains a local heating section, above which a temperature probe is located to record thermal disturbance from the heating section. The effect of free convection in a fluid on the temperature field in the pipe during and after heating is described. It is revealed that there are high-frequency temperature oscillations on sensors that record the temperature of the inner surface (wall) of the pipe and fluid above the heating area, whose value reaches higher than 2 °C and decreases when the distance to the heating region becomes longer. There is an empirical relationship that relates the time of arrival of the temperature disturbance front associated with free convection and the distance to the pipe heating region. Azimuthal temperature distribution curves on the inner wall of the pipe above the heating section are constructed in the absence and presence of a behind-the-casing flow. Qualitative criteria have been obtained indicating the presence of an azimuthally localized behind-the-casing flow (sector flow) of fluid based on the azimuthal temperature distribution analysis.
America's Maritime Energy Superhighways for CO2, Hydrogen and LNG Transportation
Authors: Pollett Buford , Johannes Ty , Atashbari Vahid 
Published: August 2024

Abstract
Throughout American history, Presidents have recognized the vital role of the nation's abundant natural resources, beginning with George Washington, who appreciated the strategic importance of navigable waterways. He notably showcased numerous paintings of rivers, including the iconic Hudson River, in the New Room of his Mount Vernon home. In recent times, there has been significant opposition from stakeholders and political leaders against pipeline construction in the United States. Consequently, the inland waterways, along with the navigable waterways of the Atlantic, the Great Lakes, and the Gulf of Mexico, offer a highly interconnected and viable alternative. These waterways form a uniform legal superhighway under US maritime law, facilitating the efficient flow of energy goods essential for energy diversification. To this end, it is crucial to embrace technological advancements and fully utilize the United States' navigable waterways. This approach supports a comprehensive energy policy that leverages all available American energy sources, enhancing energy security and meeting environmental objectives for stakeholders in Asia and Europe. This paper explores the legal framework governing CO2, LNG, and hydrogen transportation, and potential commercial development in both domestic and international markets. It provides a detailed analysis of the supply chain for capture, transport, and storage, addressing the needs of both US and global markets.
Techno-Economic Analysis of Mobile Carbon Capture for Heavy Duty Applications Across Different Regions in the World
Authors: Saafi M A. , Hamad E. 
Published: August 2024

Summary
Since signing the legally binding Paris agreement, fighting climate change has been an increasingly important task worldwide. One of the key energy sectors to emit greenhouse gases is transportation. Therefore, long term strategies all over the world have been set up to reduce on-road combustion emissions. One of the emerging alternative technologies to decarbonize the transportation sector is Mobile Carbon Capture (MCC). MCC refers to the on-board separation of CO2 from vehicle exhaust. To accurately assess this technology, a techno-economic analysis is essential to compare MCC abatement cost to alternative decarbonization technologies such as electric trucks. Adding to the system capital and operational costs, our study includes mass penalty costs, CO2 offloading and transport costs for different transport scenarios. To better relate to a single consumer (driver), the cost can be converted from dollar per-tCO2 to dollar per-trip or dollar per-mile. This study shows that MCC should be explored as a viable climate mitigation option. The novelty of this work comes from the detailed cost categories taken into consideration in the analysis, for a better MCC technology feasibility and impact analysis study. Moreover, the comparison across different regions, this study explores the potential of MCC to help decarbonize the heavy-duty sector depending on regional characteristics.
CO2 and H2 Injection Effects on Reservoir and Seal Rocks Integrity: A Meta-Analysis of Influencing Factors
Authors: Khand U. , Agbor Y. , Ling K. 
Published: August 2024

Abstract
This study presents a novel application of Meta-Analysis to comprehensively investigate the underground storage dynamics of CO2 and H2, addressing the limitations posed by existing experimental data and laboratory-scale experiments.
Our methodology capitalizes on published experimental datasets concerning reservoir and seal rock integrity, deeply investigating the effects of injected CO2 and H2 on rock properties.
Structured in three pivotal stages, our research first consolidates a wide array of studies elucidating factors influencing rock integrity, encompassing fluid properties, rock type, and inherent rock characteristics such as mineralogy and geomechanical properties. Subsequently, a systematic analysis of this aggregated data unveils critical insights into the multifaceted influencing factors. Finally, this culminates in an enriched comprehension of reservoir and seal rock behaviors pertinent to underground storage.
Our findings demonstrate the efficacy of this approach in accurately capturing detailed experimental datasets, facilitating a systematic analysis of influencing factors, and ultimately enhancing understanding of CO2 and H2 injection dynamics for underground storage applications. This comprehensive understanding also enhances our ability to predict and mitigate potential risks associated with CO2 and H2 injection, optimizing reservoir performance and maximizing hydrocarbon recovery.
Fueling the Future - Pathways Toward Zero Carbon Shipping
Authors: Choudhury Q. , Semiz O. , Segovia J. E. 
Published: August 2024

The transition from fossil fuels to zero-carbon sustainable energy will be led by the adoption of future fuels. This will effectively reduce emissions and gradually abate climate change impacts. However, this transition process is challenging and is dependent on the gradual development of technology including improving existing technology over the next few decades. This paper makes predictions on the use of various new technologies to achieve the decarbonization goals in the marine industry.
The pathways for decarbonization require gradually increasing the use of low carbon and carbon free fuels over time. Alternatives to fossil fuel combustions potentially include zero-carbon fuels, such as hydrogen or ammonia, and low-carbon fuels, such as biofuels, methanol made from plant waste, biomass etc. paired with carbon capture to prevent any released carbon from escaping into the atmosphere. This paper covers, methodically, the use of different energy options for each application, evaluates each technology along with its prospective readiness levels and finally, determine the steps needed to be taken to decarbonize the marine industry.
The 2023 IMO GHG Strategy targets net-zero emissions by or around 2050 for the marine industry. The framework represents the ambitious visions for Member States, setting goals to reduce Greenhouse Gas (GHG) emissions in the mid and long term, with possible timelines, and their impact. To meet these ambitious timelines, the whole industry needs to work together to find the correct solutions, and gradually adopt them in the coming decades. The need for green energy requires a drastic advancement of technologies from concept to production. It would not be possible to scale up clean energy dramatically in a short period, but it is possible to accomplish this phase by phase. Some clean energy may be produced from fossil fuel by sequestering and storing the excess carbon and some may be obtained from renewable resources, that said, net-zero or close to net-zero emissions will require massive technological advancements.
Enhancing Natural Gas Production Prediction Using Machine Learning Techniques: A Study with Random Forest and Artificial Neural Network Models
Authors: Bassey M. , Akpabio M. G. , Agwu O. E. 
Published: August 2024

Abstract
The International Energy Agency (IEA) in 2020 predicted that the supply of natural gas will expand globally by 4.1 percent and would continue to grow as a result of rising demand for energy in the industrial and power sectors. In order to ensure well integrity, prepare for potential interventions, and improve the energy mix and transition, accurate gas production prediction is essential.
Various models exist for predicting Natural Gas production, but currently used tools lean towards machine learning. However, Machine Learning models in extant literature yield inaccurate results due to limitations of data, predictive range, and robustness.
To address this issue, this study develops a model that combines traditional and non-traditional features to reduce computational time and increase robustness. The model uses two algorithms, Artificial Neural Network (ANN) and Random Forest (RF) Regression, and over 13,500 data points from 15 years of production. To assess the performance of this model, four statistical error metrics were employed; mean squared error (MSE), root mean squared error (RMSE), coefficient of determination (R2) and correlation coefficient (R). The ANN model achieved an accuracy of 0.93 with a MSE of 0.1244, a validation score of 0.1171, and a testing score of 0.1337. The RF Model achieved accuracy of 0.96 and an R of 0.98.
Feature selection was done on the model to provide insights on how each feature affects the model accuracy. With flowing tubing hole pressure produced contributing over 50 percent to the predictive capacity and shut-in tubing hole pressure with less than 5 percent.
In comparison with existing models, the developed models performed better in terms of predictive accuracy, robustness, predictive data range and computational time. The characteristics of the developed model for which novelty is claimed include; the explicit nature of the model that helps it be deployed in software application, the low computational time and its high predictive capacity.
The model created for this study will aid in forecasting and predicting gas production, guaranteeing its efficacy, economy, and robustness. It also serves as a starting point for further investigation into natural gas forecasting and prediction.
A Deep Dive on Stage Cementing Operations in Sub-Saharan Africa: A Case Study
Authors: Author A. O. , Author M. S. , Author N. F. , Author N. L. , Author O. C. 
Published: August 2024

Abstract
Cementing through weak sand and unconsolidated formations are a common occurrence in today's drilling operations. Main challenges include well control, poor zonal isolation, failed top of cement objectives that could lead to a shortened lifespan of wells. From annular gas migration through micro annulus to getting the top of cement to an undesired depth below referenced hydrocarbon sands, cementing through unconsolidated formations can lead to an increase in the cost of delivering a well. There are different methods deployed in cementing through unconsolidated zones. Stage cementing is one key method to ensure proper zonal isolation across formations with significantly loose sands and fault across a specified depth. With stage cementing, primary cementing can be performed in several stages to get annular cement slurry placement to specified depths without interfering with lost circulation depths. In addition to stage cementing, high performance lightweight slurry designs are common, and this is widely deployed through blending glass beads in the cement slurry designs which enables slurries achieve low density requirements without compromising compressive strength. Foam cementing is another method to lower density of slurry to aid placement in such cases. Stage cementing is not a common practice in the Sub-Saharan African region due to the lithological lay-up of formations around the region. This paper aims to perform an in-depth analysis on the design challenges, key planning consideration, materials requirement and the operational challenges that is often experienced while performing stage cementing. Different case studies of wells cemented using this method will be examined highlighting these key considerations. A breakdown will also be done on the economic models of deploying stage cementing as compared to other cementing solutions like lightweight slurry deployment. Stage cementing can provide a means to delivering cementing solutions to traditionally challenging environments in a cost-effective way which drives performance excellence.