bluuebunny/crossref_metadata_2025_split huggingface dataset:
Primary cutaneous lymphoproliferations in the gray zone between marginal zone lymphoma and CD4+ small/medium T‐cell lymphoproliferative disease
Authors: Pálos Kata , Szakonyi József , Csomor Judit , Gremsperger Åsa , Zajta Erik , Marschalkó Márta , Szepesi Ágota 
Published: July 2024

AbstractBackgroundPrimary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disease (CD4+ TLPD) are two distinct entities with excellent prognosis; however, they show profound clinical and histopathological similarities, leading to differential diagnostic uncertainty.AimsOur aim was to review and reanalyze cases of primary cutaneous lymphoproliferations diagnosed at Semmelweis University, featuring characteristics of PCMZL and CD4+ TLPD.Materials and MethodsCutaneous lymphoma biopsy specimens between 2018 and 2022 were collected and re‐evaluated. Medical history, clinical picture, imaging, and laboratory findings were collected. Immunohistochemical staining for CD20, CD3, BCL6, CD10, PD1, CD3, CD4, CD8, and PCR tests for IGH, IGK, TCRB, and TCRG were repeated in selected cases.ResultsAmong 55 cases diagnosed as PCMZL (16) or CD4+ TLPD (39), 3 patients had been diagnosed with both LPDs at different time points of their disease course. Four additional patients were identified with single lesions featuring overlapping histopathological characteristics of both LPDs and both monoclonal IGH and TCR rearrangements. All patients are currently in complete remission with local treatment.ConclusionWe propose that besides the overlapping histopathological, molecular, and clinical features, the subsequent appearance of PCMZL and CD4+ TLPD in a short timeframe in the same patients may suggest a common pathogenic background.
A comparison of mast cells in skin biopsies of cutaneous mastocytosis with other inflammatory dermatoses: A study of 33 cases
Authors: Parham Margaret M. , Krishnan Bhuvaneswari , Huttenbach Yve T. 
Published: July 2024

AbstractBackgroundHistopathologic criteria for diagnosis of cutaneous mastocytosis include 20 mast cells per high‐power field or clusters of 15 mast cells. We aimed to determine the specificity of these criteria for cutaneous mastocytosis in comparison with inflammatory disorders of mast cell activation.MethodsTwenty‐six cases of spongiotic dermatitis or urticaria were identified from 2021 to 2022. Recuts were stained with mast cell tryptase and slides were reviewed for the presence of 20 mast cells per high‐power field and for clusters of 15 mast cells. In addition, seven cases of mastocytosis were reviewed for the same criteria.ResultsTwelve of 26 cases (46.1%) of spongiotic dermatitis/urticaria had at least 20 mast cells per high‐power field. Three of 26 cases (11.5%) of spongiotic dermatitis/urticaria had a cluster of 15 mast cells. Six of seven cases (85.7%) of mastocytosis had at least 20 mast cells per high‐power field; four of seven cases (57.1%) of mastocytosis had a cluster of 15 mast cells.ConclusionsIn our study, the finding of 20 mast cells per high‐power field was nonspecific as a single criterion for cutaneous mastocytosis. The finding of clusters of 15 mast cells was more specific but not sensitive.
Brain MRI findings in paediatric genetic disorders associated with white matter abnormalities
Authors: Oikarainen Jaakko H. , Knuutinen Oula A. , Kangas Salla M. , Rahikkala Elisa J. , Pokka Tytti M.‐L. , Moilanen Jukka S. , Hinttala Reetta M. , Vieira Päivi M. , Uusimaa Johanna M. , Suo‐Palosaari Maria H. 
Published: July 2024

AbstractAimTo describe the specific brain magnetic resonance imaging (MRI) patterns of the paediatric genetic disorders associated with white matter abnormalities in Northern Finland.MethodIn this retrospective population‐based longitudinal study, brain MRI scans accumulated from 1990 to 2019 at Oulu University Hospital, Finland, were assessed. Inclusion criteria were defined as leukodystrophies or genetic diseases with significant white matter abnormalities that did not meet the criteria for leukodystrophy, at least one brain MRI, and age under 18 years at diagnosis.ResultsA total of 83 patients (48 males, 35 females) were found with 52 different diseases. The median age at the time of the brain MRI was 22 months (interquartile range [IQR] = 46 months). In 72 (87%) of the children, brain MRIs revealed abnormal findings, including cerebral white matter abnormalities (n = 49, 59%), brainstem signal abnormalities (n = 28, 34%), thinning of the corpus callosum (n = 30, 36%), delayed myelination (n = 11, 13%), and permanent hypomyelination (n = 9, 11%).InterpretationSymmetrical and bilateral white matter signal patterns of the brain MRI should raise suspicion of genetic disorders when the clinical symptoms are compatible. This study illustrates brain imaging patterns of childhood‐onset genetic disorders in a population in Northern Finland and improves the diagnostic accuracy of rare genetic disorders.
Moving from opportunity: Intergenerational mobility of rural–urban return migrants in Sweden, 1890s–1940s
Authors: Andersson Jonatan 
Published: July 2024

AbstractUsing a novel longitudinal dataset, we study the intergenerational mobility of rural–urban migrants who returned to the countryside in due course. By examining pairs of brothers during the entire migration lifecycle – from childhood until age 34 – we estimate the effect of temporarily relocating to an urban area on occupational income over the mature working ages of 35–44 between the 1890s and the 1940s in Sweden. The results show that rural–urban migrants who returned to the countryside were not failures who did not improve their social position, but instead experienced substantial gains compared with their non‐migrant brothers. These gains were similar to those of migrants who had permanently settled in urban areas. This pattern is mainly attributed to their capacities to leave farming and enter white‐collar positions to a greater extent than non‐migrants. The extent of temporary rural–urban migration, combined with the high levels of intergenerational mobility of return migrants in Sweden during the period examined, suggests that rural–urban migration to towns resulted in positive feedback effects for the countryside.
A pilot study investigating the effect of the BEGIN psychoeducation intervention for people at clinical high risk for psychosis on emotional and stigma‐related experiences
Authors: Mikelic Maxwell , Jusdanis Alexander , Bergson Zachary , DeLuca Joseph S. , Sarac Cansu , Dobbs Matthew F. , Shuster Sophia , Vaidya Shreya , Wyka Katarzyna , Yang Lawrence H. , Landa Yulia , Corcoran Cheryl M. , Herrera Shaynna N. 
Published: July 2024

AbstractAimThere is concern that the provision of the clinical high risk for psychosis (CHR) label is stigmatizing. Prior research suggests people have nuanced reactions to feedback involving the CHR label, including a positive experience receiving feedback and improvement in negative emotions (e.g., shame), while also exhibiting concerns about self‐perception and perceptions from others related to the label. The current pilot study aimed to evaluate whether individuals at CHR showed changes in emotional and stigma‐related experiences following a CHR psychoeducation intervention, BEGIN: Brief Educational Guide for Individuals in Need.MethodParticipants at CHR (N = 26) identified via the Structured Interview for Psychosis‐Risk Syndromes completed the Mental Health Attitudes Interview measuring symptom‐related and CHR label‐related stigma at pre‐ and post‐intervention.ResultsStigma did not increase and participants had greater positive emotions (e.g., feeling hopeful and relieved), post‐BEGIN.ConclusionThis study suggests that standardized CHR psychoeducation does not increase stigma in individuals at CHR.
Health indicator construction based on normal states through FFT‐graph embedding
Authors: Kim GwanPil , Jung Jason J. , Camacho David 
Published: July 2024

AbstractUnexpected faults in rotating machinery can lead to cascading disruptions of the entire work process, emphasizing the importance of early detection of performance degradation and identification of the current state. To accurately assess the health of a machine, this study introduces an FFT‐based raw vibration data preprocessing and graph representation technique, which analyses changes in frequency bands to detect early degradation trends in vibration data that may appear normal. The approach proposes a methodology that utilizes a graph convolutional autoencoder trained using only normal data to extract health indicators using the differences in the vectors as degradation progresses. This approach has the advantage of using only normal data to detect subtle performance degradation early and effectively represent health indicators accordingly.
Couple relationship education content: What we have and what we are missing
Authors: Griffes Sarah E. , Hardy Nathan R. , Gregson Ty J. , Brosi Matthew W. , Gardner Brandt 
Published: July 2024

AbstractCouple relationship education (CRE) has decades of research showing mixed results for participants. Various competing frameworks for CRE content have emerged in the development of the field, yet content has not been systematically investigated. Through an inductive content analysis of 15 different CRE programs, this study explored content themes and categories that are common across programs. Analysis found four themes throughout the programs: interactional skills, the self in the relationship, partner bonding, and relationship motivations. Categories for each theme were identified and are presented and discussed. Findings validate the primacy of teaching interactional skills within CRE including consistency in topics (e.g., communication training, conflict management). Other themes were also common (e.g., self in the relationship), though their categories were more diverse (e.g., self‐care, expectations, personality). Several factors that have emerged as more significant in relationship theory and research were not well‐represented in the content analysis (e.g., socioecological contexts, systemic patterns).
Climate change alters social‐ecological trade‐offs in achieving ocean futures' targets
Authors: Zeng Zeyu , Lam Vicky W. Y. , Sumaila U. Rashid , Cheung William W. L. 
Published: July 2024

AbstractThe effects of climate change on marine ecosystems are causing cascading impacts on livelihood, food security, and culture through fisheries. Such impacts interact and exacerbate the effects of overfishing on marine social‐ecological systems, complicating the rebuilding of ecosystems to achieve desirable and sustainable ocean futures. Developing effective pathways for ecosystem rebuilding requires consideration of the co‐benefits and trade‐offs between ecological and social dimensions and between fishing sectors. However, the effects of intensifying climate change on such co‐benefits or trade‐offs are yet to be well understood, particularly in regions where ecosystem rebuilding is urgently needed. We applied a numerical optimization routine to define the scope for improvement toward the Pareto‐frontier for ecological robustness and economic benefits of the northern South China Sea (NSCS) and the East China Sea (ECS) ecosystems. These two ecosystems were used to represent over‐exploited low‐ and mid‐latitude systems, respectively, and the optimization aimed to improve their status through fisheries management. We find that the ECS ecosystem has the possibility of increasing the economic benefits generated by the fisheries it supports under climate change by 2050 while increasing the uncertainty of achieving biodiversity objectives. Nevertheless, climate change is projected to reduce the scope to restore ecosystem structures and the potential economic benefits in the NSCS ecosystem. This study highlights the contrasting impacts of climate change on the co‐benefits/trade‐offs in ecosystem rebuilding and the benefits obtainable by different fishing sectors even in neighboring ecosystems. We conclude that consideration at the nexus of climate–biodiversity‐fisheries is a key to developing effective ecosystem rebuilding plan.
Calcium‐sensing receptor regulates the angiogenic differentiation of LPS‐treated human dental pulp cells via the phosphoinositide 3‐kinase/Akt pathway in vitro
Authors: Yang Ting , Liu Peiqi , Qiu Zixin , Zhang Yuejiao , An Shaofeng 
Published: July 2024

AbstractAimThe purpose of this study was to investigate the role of calcium‐sensing receptor (CaSR) in the angiogenic differentiation of lipopolysaccharide (LPS)‐treated human dental pulp cells (hDPCs).MethodologyThe LPS‐induced hDPCs were cultured in the medium with different combinations of CaSR agonist R568 and antagonist Calhex231. The cell proliferation, migration, and angiogenic capacity were measured by Cell Counting Kit‐8 (CCK‐8), scratch wound healing, and tube formation assays, respectively. Enzyme‐linked immunosorbent assay (ELISA), quantitative real‐time polymerase chain reaction (qRT‐PCR), and western blot were conducted to determine the gene/protein expression of CaSR, inflammatory mediators, and angiogenic‐associated markers. The activation of phosphoinositide 3‐kinase (PI3K) and protein kinase B (Akt) was assessed by western blot analysis.ResultsThe cell proliferation was elevated in response to R568 or Calhex231 exposure, but an enhanced cell migration was only found in cultures supplemented with Calhex231. Furthermore, R568 was found to potentiate the formation of vessel‐like structure, up‐regulated the protein expression of tumour necrosis factor (TNF)‐α, vascular endothelial growth factor (VEGF), and stromal cell‐derived factor (SDF)‐1; comparable influences were also observed in R568‐stimulated cells in the presence of PI3K inhibitor LY294002. In contrast, Calhex231 obviously inhibited the tube formation and VEGF protein level, whereas promoted the production of IL‐6, TNF‐α, and eNOS; however, in the presence of LY294002, Calhex231 showed a significant promotion on the protein expression of CaSR, VEGF, and SDF‐1. In addition, R568 exhibited a promotive action on the Akt phosphorylation, which can be reversed by LY294002.ConclusionsOur results demonstrated that CaSR can regulate the angiogenic differentiation of LPS‐treated hDPCs with an involvement of the PI3K/Akt signalling pathway.
Inventory rationing, admission control, and production capacity allocation in a make‐to‐stock/make‐to‐order manufacturing system
Authors: Kim Eungab 
Published: July 2024

AbstractThis paper considers a manufacturing system in which products are produced in both make‐to‐stock (MTS) and make‐to‐order (MTO) modes. Production of MTS and MTO products is done in batches, incurs a setup cost, and is non‐preemptive. The inventory of MTS products fulfills the demand of multiple classes, and each class demand can be satisfied or rejected. Customer orders for MTO production can be accepted or rejected, and their size is the same as the production batch. The primary goal of this paper is to study a policy that coordinates inventory rationing, admission control, and production capacity allocation to maximize the system's profit. We formulate the problem as a Markov decision process model and identify the structure of optimal control policies. We investigate the effect of inventory rationing on the profit by comparing its performance to that of the system with a first‐come‐ first‐serve policy to allocate inventory to multiple demand classes and study the extent to which the benefit of inventory rationing can be affected by system parameter changes. We also propose a heuristic that manages control decisions from linear threshold functions. Our test results from numerical examples show that the average percentage difference between the optimal and heuristic policies is within 1.2%.
Parauchenoglanis stiassnyae (Siluriformes: Auchenoglanididae): A new species of giraffe catfish from Mfimi‐Lukenie basin, central Africa, Democratic Republic of Congo
Authors: Modimo Myriam Y. , Bernt Maxwell J. , Monsembula Iyaba Raoul J. C. , Mbimbi José J. M. M. , Liyandja Tobit L. D. 
Published: July 2024

AbstractA new, distinctively short‐bodied giraffe catfish of Parauchenoglanis is described from the Ndzaa River, a small left‐bank tributary of the Mfimi‐Lukenie basin in the Central basin of the Congo River in the Democratic Republic of the Congo. The new species can be distinguished from all congeners by having 29 or fewer (vs. 33 or more) total vertebrae. It can further be distinguished from all congeners, except Parauchenoglanis zebratus Sithole et al., 2023 and Parauchenoglanis ngamensis (Boulenger 1911), by having 13 or 14 (vs. 16 or more) pre‐anal vertebrae. The species is endemic to the Mfimi River basin, where it has been collected mainly in blackwater tributaries.
Systematic review: risk prediction models for metachronous advanced colorectal neoplasia after polypectomy
Authors: Kang James H‐E , Levine Emma , Fleet Alex , Padilla Mc Stephen , Lee Jeffrey K , Harrison Hannah , Usher‐Smith Juliet A 
Published: July 2024

AbstractBackground and AimColorectal cancer (CRC) is the fourth leading cause of cancer death globally. CRC surveillance is a common indication for colonoscopy, representing a considerable burden for endoscopy services. Accurate identification of high‐risk patients who would benefit from more intensive surveillance, as well as low‐risk patients suitable for less frequent follow‐up, could improve the effectiveness of surveillance protocols and resource use. Our aim was to identify and critically appraise published risk models for the occurrence of metachronous advanced colorectal neoplasia (ACN), defined here as CRC or advanced adenomas detected during surveillance colonoscopy.MethodsWe searched PubMed and EMBASE for primary research studies reporting the development and/or validation of multivariable models that predict metachronous ACN risk. Screening of studies for inclusion, data extraction, and risk of bias assessment were conducted by two researchers independently.ResultsWe identified nine studies describing nine risk models. Six models were internally validated and two were externally validated. No model underwent both internal and external validation. Good model discrimination (concordance index > 0.7) was reported for two models during internal validation and for one model during external validation. Calibration was acceptable when assessed (n = 4). Methodological limitations and a high risk of bias were observed for all studies.ConclusionsSeveral published models predicting metachronous ACN risk showed some promise. However, adherence to methodological standards was limited, and only two models were externally validated. Head‐to‐head comparisons of existing models using populations independent from model development cohorts should be prioritized to identify models suitable for use in clinical practice.
Impact of Veterans Affairs Geriatric Research, Education, and Clinical Centers: Incubators of innovation in geriatrics
Authors: Farrell Timothy W. , Hogans Beth B. , Moo Lauren , Jump Robin , Markland Alayne , Alessi Cathy , Barczi Steven , Bej Taissa , Bonomo Robert A. , Butler Jorie , Eleazer G. Paul , Flinton Pamela , Rupper Randall W. , Supiano Mark A. , Shaughnessy Marianne ,   the GRECC Directors Association
Published: July 2024

AbstractSince their inception in 1975, the Department of Veterans Affairs Geriatric Research, Education, and Clinical Centers (GRECCs) have served as incubators of innovation in geriatrics. Their contributions to the VA mission were last reviewed in 2012. Herein, we describe the continuing impact of GRECCs in research, clinical, and educational areas, focusing on the period between 2018 and 2022. GRECC research spans the continuum from bench to bedside, with a growing research portfolio notable for highly influential publications. GRECC education connects healthcare professions trainees and practicing clinicians, as well as Veterans and their caregivers, to engaging learning experiences. Clinical advancements, including age‐friendly care, span the continuum of care and leverage technology to link disparate geographical sites. GRECCs are uniquely positioned to serve older adults given their alignment with the largest integrated health system in the United States and their integration with academic health centers. As such, the GRECCs honor Veterans as they age by building VA capacity to care for the increasing number of aging Veterans seeking care from VA. GRECC advancements also benefit non‐VA healthcare systems, their academic affiliates, and non‐Veteran older adults. GRECCs make invaluable contributions to advancing geriatric and gerontological science, training healthcare professionals, and developing innovative models of geriatric care.
Pathways to zero plastic waste landfill: Progress toward plastic circularity in South Africa
Authors: Olatayo Kunle Ibukun , Mativenga Paul T. , Marnewick Annlizé L. 
Published: July 2024

AbstractThe accumulation of waste in landfill is currently a challenge globally and in South Africa. The primary motivation of this research was to contribute to identifying and evaluating pathways for diverting plastic waste from landfill and advancing the plastics circular economy. This study assessed, for South Africa, key measures implemented by selected countries to promote recycling in order to divert waste from the landfill. The National Waste Management Strategy of 2020 for South Africa mandates successive waste reduction targets toward zero waste landfill by 2050. Material flow analysis (MFA) was extended from previous studies and used to map plastic flows over three successive intervals to assess progress made toward diversion of plastic waste from landfill. The percentage of plastic materials sent to landfill for South Africa were 74%, 78%, and 39% in 2017, 2019, and 2021, respectively. Potential pathways were identified as strategies for the South African to accelerate the reduction of plastic waste to landfill. These were modeled as single and as combined actions, through sensitivity analysis on the MFA‐derived Sankey diagram and used to assess their impact on waste to landfill reduction. The scenario analysis highlighted improved waste collection and waste sorting as key measures and enablers that should be developed and a priority for reduction of plastic waste to landfill before the 2050 target year. The paper presents a new generic approach that combines MFA, Sankey diagrams, and scenario analysis to explore and evaluate solution spaces for transition to a circular economy.
Industrial Chain Leader System for green governance: Evidence from a Chinese resource‐based city
Authors: Li Yingbo , Hong Zhisheng , Lin Ziqiu , Zhao Tianyi 
Published: July 2024

AbstractThe Chain Leader System (CLS) is a novel concept of industrial development proposed by the Chinese local government. Initially, it was aimed at chain extension, supplementation, and advancement to address the impact of external uncertainties. However, there has been debate about whether political power from CLS will lead to inefficiencies in green governance. This study aims to formalize industrial CLS for green governance. A survey was conducted to assess public acceptance and the validity of CLS in a resource‐based city. The results indicate that CLS, when aligned with green governance goals, effectively corresponds with market rationality and public value. It is evident that CLS represents a collective effort toward effective governance rather than simply extending industrial chains or enhancing resilience. The efficiency of green governance within CLS is influenced by the factors including communication platform, enterprises' carbon sinks and green clustering, citizens' adoption of green transportation, and communication among different stakeholders. This study provides valuable insights for the governments seeking to establish an efficient CLS that aligns with both market principles and well‐functioning government.