bluuebunny/crossref_metadata_2025_split huggingface dataset:
Reliability and minimal detectable change of dynamic temporal summation and conditioned pain modulation using a single experimental paradigm
Authors: Vincenot Matthieu , Beaulieu Louis-David , Gendron Louis , Marchand Serge , Léonard Guillaume 
Published: July 2024

Background
Quantitative sensory tests (QST) are frequently used to explore alterations in somatosensory systems. Static and dynamic QST like pain threshold and temporal summation (TS) and conditioned pain modulation (CPM) are commonly used to evaluate excitatory and inhibitory mechanisms involved in pain processing. The aim of the present study was to document the reliability and the minimal detectable change (MDC) of these dynamic QST measurements using a standardized experimental paradigm.

Material and methods
Forty-six (46) pain-free participants took part in 2 identical sessions to collect TS and CPM outcomes. Mechanical (pressure pain threshold [PPT]) and thermal (constant 2-minute heat pain stimulation [HPS]) nociceptive stimuli were applied as test stimuli, before and after a cold-water bath (conditioning stimulus). TS was interpreted as the change in pain perception scores during HPS. CPM were determined by calculating the difference in pain perception between pre- and post- water bath for both PPT and HPS. Relative and absolute reliability were analyzed with intra-class correlation coefficient (ICC2, k), standard error of the measurements (SEMeas) and MDC.

Results
Results revealed a good to excellent relative reliability for static QST (ICC ≥ 0.73). For TS, a poor to moderate relative reliability depending on the calculation methods (ICC = 0.25 ≤ ICC ≤ 0.59), and a poor relative reliability for CPM (ICC = 0.16 ≤ ICC ≤ 0.37), both when measured with mechanical stimulation (PPT) and thermal stimulation (HPS). Absolute reliability varied from 0.73 to 7.74 for static QST, 11 to 22 points for TS and corresponded to 11.42 points and 1.56 points for thermal and mechanical-induced CPM, respectively. MDC analyses revealed that a change of 1.58 to 21.46 point for static QST, 31 to 52 points for TS and 4 to 31 points for CPM is necessary to be interpreted as a real change.

Conclusion
Our approach seems well-suited to clinical use. Although our method shows equivalent relative and absolute reliability compared to other protocols, we found that the reliability of endogenous pain modulation mechanisms is vulnerable, probably due to its dynamic nature.
Evaluation of superficial xenograft volume estimation by ultrasound and caliper against MRI in a longitudinal pre-clinical radiotherapeutic setting
Authors: Roth Daniel , Safi Marcella , Vilhelmsson Timmermand Oskar , Sereti Evangelia , Molendowska Malwina , Gottschalk Michael , Bjartell Anders , Ceberg Crister , Szczepankiewicz Filip , Strand Joanna 
Published: July 2024

Background
Accurate tumor volume estimation is important for evaluating the response to radionuclide therapy and external beam radiotherapy as well as to other pharmaceuticals. A common method for monitoring the growth of subcutaneous tumors in pre-clinical models and assessing the treatment response is to measure the tumor length and width by external calipers to estimate its volume. This procedure relies on an assumption of a spheroidal tumor shape wherein the tumor depth equals the width and can yield considerably inaccuracies. Ultrasound imaging is a non-invasive technique that can measure all three axes of the tumor and might be an alternative to caliper measurement with potentially greater accuracy and comparable ease-of-use and throughput. Both 2D and 3D ultrasound imaging are possible, the former offering short scan times without the need for anesthesia and heating—valuable factors for longitudinal studies in large animal cohorts. Nevertheless, tumor volume estimation accuracy by 2D ultrasound imaging has seen limited investigation. In this study we have evaluated the accuracy of tumor volume estimation by caliper and 2D ultrasound with comparisons to reference measurements by magnetic resonance imaging (MRI) in a pre-clinical model of prostate cancer treated with either external beam radiotherapy, radionuclide therapy, or no treatment.

Results
Tumor volumes were measured longitudinally in 29 mice by caliper, ultrasound, and MRI before and after external beam radiotherapy, [177Lu]Lu-PSMA-617 radionuclide therapy, or no treatment. Caliper measurements had a marked bias, overestimating the tumor volumes by a median of 150% compared to MRI. Ultrasound measurements were markedly more accurate, with a median bias of -21% compared to MRI.

Conclusion
Ultrasound imaging is a reliable and accurate method for tumor volume estimation in pre-clinical models of radiotherapy, whereas caliper measurements are prone to overestimation.
Achieving cervical cancer elimination: The simulated impacts of HPV vaccination and transitioning from liquid-based cytology to HPV-based screening test
Authors: Balqis-Ali Nur Zahirah , Anis-Syakira Jailani , Fun Weng Hong , Mohd Said Zakiah , Abdul Samad Shazimah , Zainal Abidin Norhaslinda , Zulkepli Jafri , Ahmad Norazura , Mohd Abas Mohd Norazam , Yong Chee Meng , Yusof Siti Norbayah , Daud Nur Adila , Sararaks Sondi 
Published: July 2024

The Ministry of Health Malaysia aims to fully replace liquid-based cytology (LBC) with Human Papillomavirus (HPV) tests and increase the screening coverage from a baseline of 25% to 40% by 2023, followed by a 10% yearly increment until 70% coverage. This transition requires proper planning, including the number of tests needed and budget allocation. This study aims to simulate different transition strategies involving the shift from LBC to HPV testing with expanded screening coverage to predict their impact on cervical cancer elimination in Malaysia. A system dynamics model was developed to simulate the transition from LBC to HPV testing and HPV vaccination coverage in Malaysia. The dynamic model utilised local epidemiological data, published research, and expert opinion when data was unavailable. The simulation showed that a combination of high HPV vaccination coverage and transitioning fully to five-yearly HPV testing by 2030, coupled with a 70% screening uptake by 2040, would accelerate cancer elimination in Malaysia by 18 years with an estimated screening cost of MYR1.81 billion equivalent to USD 411 millions compared to the baseline of using LBC as the primary screening method (MYR1.39 billion, USD 315 millions). Sustained, it would lead to averting 6,000 new cancer cases by 2070. Alternatively, conducting HPV screenings twice before age 50 would advance cervical cancer elimination by 14 years and prevent approximately 1000 new cases by 2070, with an estimated cost of MYR1.13 billion equivalent to USD 257 millions. A delay in achieving the full transition prolonged the elimination more than a delay in increasing the screening coverage. In all scenarios, yearly vaccination of 90% of girls age 13 is crucial to achieving elimination. In the Malaysian context, where HPV vaccination coverage has reached considerable levels, the evidence advocates for a full transition from LBC to HPV testing, ideally by 2030. While expanding screening coverage remains a critical factor in this endeavour, the findings unequivocally endorse prioritising the transition process.
Trial registration: Trial registration number: NMRR ID-22-00187-DJU.
Deep Learning Model Using Stool Pictures for Predicting Endoscopic Mucosal Inflammation in Patients With Ulcerative Colitis
Authors: Lee Jung Won , Woo Dongwon , Kim Kyeong Ok , Kim Eun Soo , Kim Sung Kook , Lee Hyun Seok , Kang Ben , Lee Yoo Jin , Kim Jeongseok , Jang Byung Ik , Kim Eun Young , Jo Hyeong Ho , Chung Yun Jin , Ryu Hanjun , Park Soo-Kyung , Park Dong-Il , Yu Hosang , Jeong Sungmoon ,   on behalf of IBD Research Group of KASID and Crohn's and Colitis Association in Daegu-Gyeongbuk (CCAiD)
Published: July 2024

INTRODUCTION:
Stool characteristics may change depending on the endoscopic activity of ulcerative colitis (UC). We developed a deep learning model using stool photographs of patients with UC (DLSUC) to predict endoscopic mucosal inflammation.

METHODS:
This was a prospective multicenter study conducted in 6 tertiary referral hospitals. Patients scheduled to undergo endoscopy for mucosal inflammation monitoring were asked to take photographs of their stool using smartphones within 1 week before the day of endoscopy. DLSUC was developed using 2,161 stool pictures from 306 patients and tested on 1,047 stool images from 126 patients. The UC endoscopic index of severity was used to define endoscopic activity. The performance of DLSUC in endoscopic activity prediction was compared with that of fecal calprotectin (Fcal).

RESULTS:
The area under the receiver operating characteristic curve (AUC) of DLSUC for predicting endoscopic activity was 0.801 (95% confidence interval [CI] 0.717–0.873), which was not statistically different from the AUC of Fcal (0.837 [95% CI, 0.767–0.899, DeLong P = 0.458]). When rectal-sparing cases (23/126, 18.2%) were excluded, the AUC of DLSUC increased to 0.849 (95% CI, 0.760–0.919). The accuracy, sensitivity, and specificity of DLSUC in predicting endoscopic activity were 0.746, 0.662, and 0.877 in all patients and 0.845, 0.745, and 0.958 in patients without rectal sparing, respectively. Active patients classified by DLSUC were more likely to experience disease relapse during a median 8-month follow-up (log-rank test, P = 0.002).

DISCUSSION:
DLSUC demonstrated a good discriminating power similar to that of Fcal in predicting endoscopic activity with improved accuracy in patients without rectal sparing. This study implies that stool photographs are a useful monitoring tool for typical UC.
Reaction of potassium germabenzenide with benzil: Unusual ring opening to form a unique polycyclic penta-coordinated germanate
Authors: Tsuji Shingo , Nishino Ryohei , Tokitoh Norihiro , Yamada Hiroko , Mizuhata Yoshiyuki 
Published: July 2024

Abstract
The reaction of potassium 2-t-Bu-germabenzenide, in which the anionic carbon atom of phenyl anion is replaced with a germanium atom, with benzil resulted in the 1:2 reaction to give a unique penta-coordinated germanate having a 1,3,2-dioxagermole skeleton. This clearly reflects the characteristics of the germabenzenide as a divalent germanium species.
HOSPITALITY AS PART OF THE COMMUNICATIVE CULTURE IN THE MERCHANT ENVIRONMENT OF SIBERIA (LATE 18TH – EARLY 20TH CENTURY)
Authors: Комлева Е.В. 
Published: July 2024

В статье представлена характеристика традиций гостеприимства, распространенных в среде сибирского купечества на протяжении конца XVIII – начала XX в. На основе источников разных видов, в том числе эго-текстов, созданных и самими купцами, и представителями других социальных слоев, выявлены такие составляющие приема гостей в купеческом кругу, как организация парадного обеда, сопровождавшие его увеселения, показано отношение к подобным мероприятиям современников. Отмечены происходившие с течением времени изменения в сервировке праздничного стола, вкусовых пристрастиях богатых сибиряков, совместных формах проведения досуга. Подчеркнуто значение хлебосольства как средства взаимопомощи, налаживания дружеских и деловых связей, проявления лояльности и уважения. Все это делало радушную встречу гостей и совместные застолья одним из важнейших элементов культуры общения среди деловых кругов региона, создавая новые возможности для укрепления собственного авторитета, развития отношений с партнерами по бизнесу и региональной администрацией.
The article presents the characteristics of the hospitality traditions common among the Siberian merchants during the late 18th – early 20th century. Until now, insufficient attention has been paid to this topic, meanwhile, the reception of guests played an important role in the daily life and communicative culture of merchants. The article is written in line with historical anthropology, which focuses on the daily practices of ordinary members of society, on persons of the “second and third plan” with their needs and interests. Based on sources of various types, including ego texts created by the merchants themselves and representatives of other social strata, such components of the reception of guests in the merchant circle as the organization of a ceremonial dinner, entertainment accompanying the meal, and the attitude of contemporaries to such events are revealed. The article shows changes in the serving of the festive table and the taste preferences of rich Siberians, as well as joint forms of leisure activities. The importance of hospitality as a means of mutual assistance (which was extremely important for the vast spaces of North Asia), establishing friendly and business ties, showing loyalty and respect is emphasized. On the one hand, the assimilation of the general imperial norms by the regional culture is noted, on the other hand, the specific behavior of Siberians (with openness, sincerity, and willingness to help being more noticeable compared with the population of European part of the country), which has developed under the influence of local factors, is noted as well. All of this combined made a cordial welcome of guests and joint feasts one of the most important elements of the culture of communication among the business circles of the region, creating opportunities to strengthen their own authority, and develop relations with business partners and regional administration.
REPORTS OF F.F. RIDDER AS A SOURCE ON SHIPPING IN SIBERIA IN THE EARLY 19th CENTURY
Authors: Долгушин И.Д. 
Published: July 2024

Статья посвящена анализу отчетов, составленных в 1810-х гг. инженер-полковником Ф.Ф. Риддером, находившимся на службе в X округе путей сообщения, по заданию руководства Управления водных и сухопутных сообщений принца Г.Т. Ольденбургского и инженер-генерала Ф.П. Деволанта. Оба его отчета вместе с перепиской, которая велась в ходе их составления, хранятся в настоящее время в Российском государственном историческом архиве. Эти документы являются ценным источником по истории экономического развития Сибири, позволяющим оценить состояние и хозяйственное значение внутренних водных путей азиатской части Российской империи в 1810-х гг. – важный период истории развития речного судоходства Сибири, когда государство проявляло значительную в нем заинтересованность. В статье рассматриваются история создания отчетов, их структура, приводятся сведения о развитии водных коммуникаций, транспортной инфраструктуре Сибири и предложения Ф.Ф. Риддера по улучшению судоходства. Автором сделан вывод о заинтересованности властей в результатах работ Ф.Ф. Риддера.
At the beginning of the 19th century, river navigation in the Russian Empire was actively developing. The active development and improvement of inland navigation was facilitated by the changes that occurred in the management of communication routes at the end of the first decade of the 19th century. The study of the shipping in conditions of Siberia was entrusted to engineer-colonel Filipp Filippovich Ridder. His written reports on the state of the inland waterways of the Asian part of the empire are the most important and interesting historical source from which it is possible to obtain unique information about the economy and transport infrastructure of Siberia. The information they provide, which is largely unique, can become the basis for many further studies. Works by F.F. Ridder, carried out in line with the general increase in the state’s interest in water communications, were of great importance for the development of inland navigation in the Asian part of the Russian Empire. He was the first to produce such a complete description of the shipping routes and drew attention to the existing difficulties in their operation. The authorities’ reaction to F.F. Ridder’s reports shows their great interest in the results of the work; it one can infer that in general the period of the 1810s was an important milestone in the history of inland waterways throughout the country and specifically in Siberia and the Far East. The name of Filipp Filippovich Ridder can rightfully take an honorable place in the list of their most outstanding researchers.
“THE LIFE WORK OF EGOR EGOROV”: THE FIRST RESULTS OF A SCIENTIFIC DESCRIPTION OF THE BOOK COLLECTION (Anisimova T.V. Catalogue of Slavic-Russian manuscripts from the collection of E.E. Egorov / Ed. by Yu.S. Belyankin. Moscow, Pashkov Dom, 2017. Vol. 1. 374 p.; 2019. Vol. 2. 335 p.; 2021. Vol. 3. 490 p.)
Authors: Демидова Л.Д. 
Published: July 2024

Анализируется научное описание 300 рукописных книг из собрания Е.Е. Егорова, подготовленное сотрудником Российской государственной библиотеки Т.В. Анисимовой. Собрание, хранящееся в отделе рукописей (ф. 98), имеет исключительную ценность для изучения книжной культуры средневековой Руси. Рассмотрены структура и методика описания, информативность представленных сведений. Показано, как благодаря тщательной работе археографа могут быть уточнены или даже изменены представления о датировке или происхождении рукописных книг собрания. Отмечен высокий профессиональный уровень издания, выполненного с опорой на результаты актуальных научных исследований.
The review is devoted to the scientific description of manuscripts from the collection of E.E. Egorov, prepared by T.V. Anisimova, an employee of the Russian State Library. The three published volumes cover the first 300 manuscripts (100 in each volume) of a collection that includes over 2000 items and is of exceptional value for the study of the book culture of medieval Rus’. The bulk of the described handwritten books date back to the 15th–17th centuries. These are liturgical books and ecclesiastical writings (homilies, sermons, commentaries on holy scriptures, hagiographies of saints), the content of which is closely related to the annual liturgical cycle. Many of the books are remarkable for their decoration (the publication is accompanied by colored illustrations). The structure of the description includes elements such as dating by watermarks of paper, characteristics of the book block, handwriting, binding, ornamental features, a detailed list of works included in a book or of parts of one work, inscriptions and owner’s notes, information about preservation, bibliography of works dedicated to either the study of the described handwritten book, or the works included in it. Thanks to the compiler’s consistent use of modern methods of archaeographic description, the information presented in the catalogue is extremely informative. Thus, taking all the watermarks of a manuscript into account helps to correct its research dating in some cases. A distinctive feature of the catalogue is its thorough research component: the catalogue contains a lot of specific archaeographic and bibliological information identified during the work on it, which will be useful to manuscript researchers. Some of these results are reflected in the scientific publications of T.V. Anisimova. The catalogue by itself accumulates current results of the collection’s manuscripts studies by a wide range of specialists. The catalogue not only testifies to the high professional level of its creator, but clearly demonstrates the wide capabilities and methods of modern archaeography in determining the composition, origin and existence of manuscripts.
pazatiempo y las prácticas pedagógicas de las estudiantes de Licenciatura en Educación Infantil
Authors: Contreras-Sierra Angélica Lucía , Lagos-Romero Elizabeth , Moreno-Patiño Karen Lizeth 
Published: July 2024

El programa de Licenciatura en Educación Infantil modalidad Distancia del Centro Universitario Soacha, de la Corporación Universitaria Minuto de Dios, ha implementado dentro de sus prácticas el proyecto social “Pazatiempo”, que tiene el propósito de fortalecer las infancias del municipio de Soacha consolidando redes sociales de apoyo para su protección, disminuyendo algunas problemáticas que padecen, para lo cual se aplicaron estrategias pedagógicas contextualizadas a sus realidades, además les permite a las estudiantes del programa desarrollar habilidades propias del educador infantil. Esta implementación se desarrolló en los periodos 2022-2 y 2023-1 en las comunas 1 y 6 del municipio, con una participación de 57 infantes y 9 adultos mayores. Para su aplicación se empleó la metodología de Marco Lógico, que permite que su estructuración sea pertinente a las necesidades de las comunidades, y que desde la praxeología las estudiantes desarrollen procesos reflexivos consolidando sus habilidades de educadores infantiles.
The Solidaristic Doctrine on Law and the State in the Works of the Legal Scholar G.K. Gins
Authors: Zaynutdinov D. R. 
Published: July 2024

The paper examines the life path of Georgiy K. Gins (1887–1971) and the formation of his political and legal ideas, which complemented the general solidaristic doctrine on law and the state. The study of the scientist’s solidarity views was conducted based on his writings on various problems of law, politics and economics. The work also traces the activities of G. K. Gins in the state authorities of the Russian Empire, in the Provisional Government and anti-Bolshevik state formations. The work shows how the crisis of power of the Provisional Government, and later the collapse of the anti-Bolshevik regimes during the Civil War forced G. K. Gins to reconsider his views on liberal democracy and abandon it in favor of solidarity.The study made it possible to trace the formation of state-legal views of G. K. Gins before he adopted the ideology of solidarity. The paper presents the types of state participation in the national economy formulated by the scientist, the concept of coordination law. It is important to note that his understanding of administrative law is in many ways similar to the modern «service concept» developing within this industry. The solidaristic doctrine of law and the state, which was developed by G. K. Gins, is an undoubted asset of Russian political and legal thought.
Suara Naratif dalam Na Willa Karya Reda Gaudiamo: Perspektif Naratologi Gerard Genette
Authors: Zahro Alhasanah , Indrastuti Novi Siti Kussuji 
Published: July 2024

Novel anak Na Willa memiliki perbedaan signifikan dalam pembangunan narasi dibandingkan dengan cerita anak pada umumnya. Perbedaan tersebut terlihat dalam pendekatan terhadap penyampaian nasihat, ajaran, dan moral. Dalam Na Willa narasi tersebut masih tetap ada, tetapi bukan sebagai tujuan cerita. Penelitian ini bertujuan untuk menemukan suara naratif dan mengungkap fungsinya dalam novel Na Willa. Metode yang digunakan dalam penelitian ini adalah metode deskriptif kualitatif dengan menggunakan pendekatan teori naratologi Gerard Genette Hasil penelitian mengidentifikasi tiga kategori suara naratif dalam novel ini, meliputi 1) waktu penceritaan dengan teknik subsequent, prior, simultaneous, dan interpolated, 2) teknik narator menggunakan narator homodiegetik dan autodiegetik, serta 3) tingkat naratif pada ekstradiegetik-homodiegetik. Temuan ini menyimpulkan bahwa fungsi suara naratif dalam novel tidak hanya sebagai alat untuk menyampaikan cerita, tetapi juga berfungsi untuk membangun kedekatan emosional dengan pembaca. Pendekatan menggunakan sudut pandang atau perspektif anak-anak sebagai narator dan tokoh utama memungkinkan pembaca anak untuk merasa lebih terhubung dan menikmati cerita dengan lebih bebas dan kreatif.