bluuebunny/crossref_metadata_2025_split huggingface dataset:
Characterization and improved quantification of left ventricular inflow using streamline visualization with 4DFlow MRI in healthy controls and patients after atrioventricular septal defect correction
Authors: Calkoen Emmeline E. , Roest Arno A.W. , Kroft Lucia J.M. , van der Geest Rob J. , Jongbloed Monique R.M. , van den Boogaard Pieter J. , Blom Nico A. , Hazekamp Mark G. , de Roos Albert , Westenberg Jos J.M. 
Published: August 2014

PurposeTo evaluate trans‐left atrioventricular valve (LAVV) blood flow and optimize left ventricular inflow quantification in healthy controls and patients after atrioventricular septal defect (AVSD) correction.Materials and MethodsTwenty‐five patients after AVSD correction and 25 controls underwent 4DFlow MRI. Using streamline visualization in four‐ and two‐chamber views, inflow direction at early and late filling was defined at the annulus level and at the peak inflow velocity (PIV) level. Trans‐LAVV flow volume and velocity were assessed from a static 2D‐multiplanar‐reformat (MPR), a 4D‐MPR tracking LAVV annulus and a 4D‐MPR tracking the PIV‐level, angulated perpendicular to the inflow.ResultsIn patients, on average 9° more laterally directed inflow was found at the PIV‐level compared to controls. In controls, 4DFlow velocity mapping with LAVV annulus tracking resulted in lower absolute error with aortic flow (3 (1–8) mL) than with static 2D‐MPR (7 (4–16) mL, P = 0.001). In patients, 4D‐MPR tracking the PIV‐level, resulted in lower absolute error with aortic flow (2 (1–4) mL) than with 4D‐MPR LAVV annulus tracking (6 (2–10) mL, P = 0.003).ConclusionStreamline visualization of 4DFlow MRI data revealed dynamic trans‐LAVV inflow and more lateral flow after AVSD correction. Streamline visualization improved trans‐LAVV flow quantification as the positioning and angulation of the measurement plane was optimized, allowing an accurate assessment of left ventricular inflow. J. Magn. Reson. Imaging 2015;41:1512–1520. © 2014 Wiley Periodicals, Inc.
A Comparison Study of Distribution‐Free Multivariate SPC Methods for Multimode Data
Authors: Grasso Marco , Colosimo Bianca Maria , Semeraro Quirico , Pacella Massimo 
Published: August 2014

The data‐rich environments of industrial applications lead to large amounts of correlated quality characteristics that are monitored using Multivariate Statistical Process Control (MSPC) tools. These variables usually represent heterogeneous quantities that originate from one or multiple sensors and are acquired with different sampling parameters. In this framework, any assumptions relative to the underlying statistical distribution may not be appropriate, and conventional MSPC methods may deliver unacceptable performances. In addition, in many practical applications, the process switches from one operating mode to a different one, leading to a stream of multimode data.Various nonparametric approaches have been proposed for the design of multivariate control charts, but the monitoring of multimode processes remains a challenge for most of them. In this study, we investigate the use of distribution‐free MSPC methods based on statistical learning tools. In this work, we compared the kernel distance‐based control chart (K‐chart) based on a one‐class‐classification variant of support vector machines and a fuzzy neural network method based on the adaptive resonance theory. The performances of the two methods were evaluated using both Monte Carlo simulations and real industrial data. The simulated scenarios include different types of out‐of‐control conditions to highlight the advantages and disadvantages of the two methods. Real data acquired during a roll grinding process provide a framework for the assessment of the practical applicability of these methods in multimode industrial applications. Copyright © 2014 John Wiley & Sons, Ltd.
Robustness properties of a sequential test for vaccine safety in the presence of misspecification
Authors: Franks Riley , Sandhu Sukhminder , Avagyan Armen , Lu Yun , Hong Han , Garcia Bruno , Worrall Christopher , Kelman Jeffrey , Ball Robert , MaCurdy Thomas 
Published: August 2014

AbstractThe Updating Sequential Probability Ratio Test (USPRT) developed by MaCurdy et al.. (2009, Updating sequential probability ratio test for real‐time surveillance of vaccine safety, unpublished working paper) has been used by the U.S. Food and Drug Administration for near real‐time surveillance of the safety of the flu vaccine since 2008. This procedure was the first method developed to account for data delay in pharmacovigilance studies. However, the current implementation is based on the strong assumption that the clinical and reporting delays do not vary from previous years. When this assumption does not hold, size distortion of the USPRT procedure might result. The goal of this article is to numerically investigate the robustness of the detection probabilities of the USPRT method with respect to possible misspecification of the clinical and reporting delay distributions through extensive simulations. We find that if the delay distribution used in calibrating the critical bound is lengthier than the delay distribution in the data generating process, then there is a higher rate of false signaling and vice versa. This is an inherent property of a real‐time testing procedure. However, the distortion created by misspecifying the reporting delay distribution appears to be insignificant when compared to the overall power generated by an elevation of the adverse event rate. The size distortion is unevenly distributed across the interim tests, so the effect of misspecification of the delay distributions is more prominent in the median time‐to‐signal. In summary, although a misspecified delay distribution induces size distortion, we find that it does not erode the overall power.
Survival analysis with electronic health record data: Experiments with chronic kidney disease
Authors: Hagar Yolanda , Albers David , Pivovarov Rimma , Chase Herbert , Dukic Vanja , Elhadad Noémie 
Published: August 2014

AbstractThis article presents a detailed survival analysis for chronic kidney disease (CKD). The analysis is based on the electronic health record (EHR) data comprising almost two decades of clinical observations collected at New York‐Presbyterian, a large hospital in New York City with one of the oldest electronic health records in the United States. Our survival analysis approach centers around Bayesian multiresolution hazard modeling, with an objective to capture the changing hazard of CKD over time, adjusted for patient clinical covariates and kidney‐related laboratory tests. Special attention is paid to statistical issues common to all EHR data, such as cohort definition, missing data and censoring, variable selection, and potential for joint survival and longitudinal modeling, all of which are discussed alone and within the EHR CKD context.
Utilizing hunter harvest effort to survey for wildlife disease: A case study of West Nile virus in greater sage‐grouse
Authors: Dusek Robert J. , Hagen Christian A. , Franson J. Christian , Budeau David A. , Hofmeister Erik K. 
Published: August 2014

ABSTRACTGreater sage‐grouse (Centrocercus urophasianus; sage‐grouse) are highly susceptible to infection with West Nile virus (WNV), with substantial mortality reported in wild populations and in experimentally infected birds. Although sage‐grouse are hunted throughout much of their range, they have also recently been considered for protection under the Endangered Species Act. We used blood samples collected on filter‐paper strips during the 2006–2010 Oregon, USA, annual sage‐grouse hunt to survey for specific WNV‐neutralizing antibodies that indicate a previous infection with WNV. During this period, hunters submitted 1,880 blood samples from sage‐grouse they harvested. Samples obtained were proportional for all 12 Oregon sage‐grouse hunting units. Laboratory testing of 1,839 samples by the WNV epitope‐blocking enzyme‐linked immunosorbent assay (bELISA) followed by plaque reduction neutralization test on bELISA‐positive samples yielded 19 (1%) and 1 (0.05%) positive samples, respectively. These data provided early baseline information for future comparisons regarding the prevalence of WNV‐specific neutralizing antibodies in sage‐grouse in Oregon. This methodology may provide other states where sage‐grouse (or other species) populations are hunted and where WNV constitutes a species conservation concern with a viable option to track the relative prevalence of the virus in populations. © 2014 The Wildlife Society.
A New Side‐on End‐On Ditantalum Dinitrogen Complex and Its Reaction with BuSiH3
Authors: Yeo Alyssa , Shaver Michael P. , Fryzuk Michael D. 
Published: August 2014

AbstractThe formation of the P‐cyclohexyl dinitrogen complex, (CyPh[NPN]Ta)2(μ‐η2:η1‐N2)(μ‐H)2 (CyPh[NPN] = [CyP(CH2SiMe2NPh)2], and Cy = C6H11) is described and its reaction with butylsilane (BuSiH3) explored. The reaction was monitored by multinuclear NMR spectroscopy and showed the formation of a number of intermediates. The final product is a hydride‐bridged imido‐amido silyated species that has the imido bridging between the two central tantalum atoms. The origin of the bridging hydrides in the product is likely to arise from the excess silane present, on the basis of labeling studies.
Structures and Properties of Coordination Polymers based on 5‐Nitroisophthalic Acid and N,N′‐bis(4‐pyridyl‐methyl) Piperazine
Authors: Xu Bo , Zhang Tao , Zhang Lei , Li Cun Cheng 
Published: August 2014

AbstractTwo coordination polymers constructed from N,N′‐bis‐(4‐pyridyl‐methyl) piperazine (bpmp) linker and 5‐nitroisophthalic acid (H2nip) of the formula {[Co2.5(bpmp)2(nip)2(Hnip)(H2O)]·3H2O}n (1) and {[Cd(bpmp)(5‐nip)(H2O)]·3H2O}n (2) were synthesized under hydrothermal conditions. Single crystal X‐ray diffraction analysis revealed that complex 1 has trinuclear and mononuclear units, which are further extended to a 3D framework, whereas complex 2 has a 2D 44‐sql [also called (4,4)‐net] layer structure. The compounds were characterized by IR spectroscopy, elemental analysis, thermogravimetric analysis, and powder X‐ray diffraction. Furthermore, the magnetic measurement of 1 reveals that it exhibits antiferromagnetic coupling interactions. The photoluminescent study on a solid sample of 2 indicates fluorescent emission at room temperature.
Serum phosphate levels reflect responses to cardiac resynchronization therapy in chronic heart failure patients
Authors: Kamiyama Yoshiyuki , Suzuki Hitoshi , Yamada Shinya , Kaneshiro Takashi , Takeishi Yasuchika 
Published: August 2014

AbstractBackgroundRecent studies have shown that high levels of serum phosphate are associated with adverse cardiovascular events. However, little is known about the relation between phosphate levels and improvement of cardiac function in chronic heart failure (CHF) patients who underwent cardiac resynchronization therapy (CRT). The purpose of this study was to examine whether serum phosphate levels were able to predict responders to CRT and adverse cardiac events.MethodsThe study population consisted of 30 CHF patients (24 males, mean age 65.7±8.5 years) who received CRT with defibrillator (CRT‐D) implantation. Levels of serum phosphate were measured before, and 6 months after, CRT‐D implantation. Left ventricular end‐diastolic volume and end‐systolic volume were assessed simultaneously by echocardiography. In addition, the rate of re‐hospitalization due to worsening of heart failure was investigated. All patients were divided into 2 groups: responders (Group‐R, n=18) and non‐responders (Group‐NR, n=12) to CRT‐D. Responders were defined as patients who showed >15% reduction in left ventricular end‐systolic volume. We compared these parameters between the 2 groups.ResultsSerum phosphate levels were significantly lower in Group‐R than in Group‐NR (3.3±0.2 vs. 3.7±0.4 mg/dL, p=0.01). The rate of re‐hospitalization was lower in Group‐R than in Group‐NR (0% vs. 33%, p=0.018). Multivariate analysis showed that serum phosphate levels had a predictive power to determine responders to CRT (odds ratio 0.008, 95% confidence interval 0.000–0.348, p=0.015).ConclusionsThese results suggest that serum phosphate levels might predict both responders to CRT, and adverse cardiac events, in CHF patients with CRT‐D.
Eighteen years of Antillean manatee Trichechus manatus manatus releases in Brazil: lessons learnt
Authors: Normande Iran Campello , Luna Fabia De Oliveira , Malhado Ana Cláudia Mendes , Borges João Carlos Gomes , Viana Junior Pitágoras Carlos , Attademo Fernanda Löffer Niemeyer , Ladle Richard J. 
Published: August 2014

AbstractThe Antillean manatee Trichechus manatus manatus was once widespread from the south-eastern coast of Brazil to Central America and the Caribbean. In Brazil habitat destruction and overhunting severely reduced and fragmented the wild population, restricting extant subpopulations to the north and north-east coast. In response to these threats an ambitious government-led programme was initiated in 1994, with the aim of rehabilitating orphaned manatee calves and releasing them into the southernmost subpopulation. The programme is unique within Brazil, and has invested unprecedented resources in post-release monitoring. So far 30 manatees have been released at three sites, with a high rate of success (> 75%). Time in captivity appears to be a key variable determining post-release success: too long or too short a time in captivity decreasing the probability of survival. We describe the main features of this long-term programme and identify six key lessons learnt: (1) close monitoring, health assessments and rescues can significantly increase the success of releases, (2) combining different monitoring techniques results in high-quality data and reduces tracking costs, (3) long-term studies are needed to effectively evaluate the results, (4) releasing manatees at c. 5 years of age can increase chances of success, (5) soft-release is important to aid acclimatization, and (6) the programme has been effective in raising awareness among the general public, supporting education and fund-raising.
Ratio of anogenital warts between different anatomical sites in homosexual and heterosexual individuals in Australia, 2002–2013: implications for susceptibility of different anatomical sites to genital warts
Authors: CHOW E. P.F. , LIN A. C. , READ T. R. H. , BRADSHAW C. S. , CHEN M. Y. , FAIRLEY C. K. 
Published: August 2014

SUMMARYThere is little known regarding the transmissibility of human papillomavirus (HPV) between different sites in men who have sex with men (MSM) and heterosexual individuals. We conducted a retrospective analysis investigating all new patients attending the Melbourne Sexual Health Centre in Australia between 2002 and 2013. We describe the prevalence and ratio of the first episode of anogenital warts in MSM and heterosexual males and females. The proportion of new MSM clients with anal and penile warts was 4·0% (362/8978) and 1·6% (141/8978), respectively; which gave an anal-to-penile wart ratio of 1:2·6. About 13·7% (1656/12112) of heterosexual males had penile warts and 10·0% (1121/11166) of females had vulval warts, which yielded a penile-to-vulval wart ratio of 1:0·7. Penile–anal transmission has a higher ratio than penile–vulval transmission, suggesting that the anal epithelium may be more susceptible to HPV infection than the vulval epithelium in females; these ratios are important in modelling the control of HPV in MSM.
Can More Be Less? An Experimental Test of the Resource Curse
Authors: Al-Ubaydli Omar , McCabe Kevin , Twieg Peter 
Published: August 2014

AbstractSeveral scholars have argued that abundant natural resources can be harmful to economic performance under bad institutions and helpful when institutions are good. These arguments have either been theoretical or based on naturally occurring variation in natural resource wealth. We test this theory by using a laboratory experiment to reap the benefits of randomized control. We conduct this experiment in a virtual world (Second Life™) to make institutions more visceral. We find support for the theory.
Tissue multifractality and Born approximation in analysis of light scattering: a novel approach for precancers detection
Authors: Das Nandan , Chatterjee Subhasri , Kumar Satish , Pradhan Asima , Panigrahi Prasanta , Vitkin I. Alex , Ghosh Nirmalya 
Published: August 2014

AbstractMultifractal, a special class of complex self-affine processes, are under recent intensive investigations because of their fundamental nature and potential applications in diverse physical systems. Here, we report on a novel light scattering-based inverse method for extraction/quantification of multifractality in the spatial distribution of refractive index of biological tissues. The method is based on Fourier domain pre-processing via the Born approximation, followed by the Multifractal Detrended Fluctuation Analysis. The approach is experimentally validated in synthetic multifractal scattering phantoms and tested on biopsy tissue slices. The derived multifractal properties appear sensitive in detecting cervical precancerous alterations through an increase of multifractality with pathology progression, demonstrating the potential of the developed methodology for novel precancer biomarker identification and tissue diagnostic tool. The novel ability to delineate the multifractal optical properties from light scattering signals may also prove useful for characterizing a wide variety of complex scattering media of non-biological origin.
The Regulatory Effect of UL-16 Binding Protein-3 Expression on the Cytotoxicity of NK Cells in Cancer Patients
Authors: Mou Xiao , Zhou Yuepeng , Jiang Peng , Zhou Tong , Jiang Qian , Xu Chengcheng , Liu Hongli , Zheng Tingting , Yuan Guoyue , Zhang Yanyun , Chen Deyu , Mao Chaoming 
Published: August 2014

AbstractThe activating immunoreceptor NKG2D (natural killer group 2, member D) and its ligands play important roles in the innate and adaptive immune responses. UL16-binding protein 3 (ULBP3), an NKG2D ligand, is overexpressed on certain epithelial tumor cells. In this study, we investigated the effect of ULBP3 expression on the cytotoxic activity of natural killer (NK) cells. ULBP3 were measured by flow cytometry analysis, immunohistochemistry and time-resolved fluoroimmunoassay. The cytotoxicity of NK cells was determined with the lactate dehydrogenase release assay. We found that ULBP3 was overexpressed on tumor cell lines and tumor tissues. Serum from cancer patients, but not from healthy donors, contained elevated levels of soluble ULBP3 (sULBP3). Importantly, high expression of ULBP3 on the cell surface of tumor cells augmented NKG2D-mediated NK cell cytotoxicity. However, low levels of sULBP3 (<15 ng/ml) weakened the cytotoxicity of NK cells by decreasing NKG2D expression on NK cells. Further analysis showed that serum samples from most cancer patients (>70%) contained the low level of sULBP3. Our results demonstrate that tumor cells express surface and soluble ULBP3, which regulate NK cell activity. Thus, ULBP3 is a potential therapeutic target for improving the immune response against cancer.
Bioinformatic analysis reveals a pattern of STAT3-associated gene expression specific to basal-like breast cancers in human tumors
Authors: Tell Robert W. , Horvath Curt M. 
Published: August 2014

SignificanceThis research, for the first time to our knowledge, elucidates patterns of mRNA, protein, and microRNA expression uniquely associated with STAT3 signaling in basal-like but not other subtypes of breast cancer, indicating STAT3 as a potential subtype-specific regulator of breast cancer malignancy.
Roles of cGMP-dependent protein kinase I (cGKI) and PDE5 in the regulation of Ang II-induced cardiac hypertrophy and fibrosis
Authors: Patrucco Enrico , Domes Katrin , Sbroggió Mauro , Blaich Anne , Schlossmann Jens , Desch Matthias , Rybalkin Sergei D. , Beavo Joseph A. , Lukowski Robert , Hofmann Franz 
Published: August 2014

Significance
It has been reported that elevation of cGMP and activation of cGMP-dependent protein kinase I (cGKI) by inhibition of PDE5 activity with sildenafil prevents cardiac hypertrophy. We studied the roles of cGKI and PDE5 inhibition on angiotensin (AII)-induced hypertrophy and fibrosis using control (Ctr) mice and mice expressing cGKI only in cells where the smooth muscle SM22α promotor is active (βRM). In Ctr mice, sildenafil did not reduce the AII-induced increase of cardiomyocyte (CM) size or myocyte hypertrophic markers but did reduce fibrosis. In βRM mice, sildenafil had little or no effect on markers of fibrosis. These results show that the sildenafil/cGMP/cGKI cascade can have an inhibitory effect on cardiac fibrosis but not on CM hypertrophy.
Addressee orientation in political speeches
Authors: Schröter Melani 
Published: August 2014

This article suggests that the addressees as the dialogical ‘other’ loom large in monological political speeches. However, political speeches are produced under conditions of addressee heterogeneity, i.e. the speakers do not actually know who they will be talking to. It will be argued that the addressees are nevertheless a crucial element in speakers’ context models, that speakers orientate towards imagined addressees and that certain aspects – what possible addressees may do, think or believe and that they are a part of an imagined community – are particularly relevant from the speakers’ point of view. An analysis of addressee orientation in political speeches aims at reconstructing speakers’ conceptualisations of possible addressees. The analysis reveals patterns of addressee orientation which suggest that the addressees are framed in terms of epistemic proximity, i.e. presumed nearness (agreement) or distance (disagreement) to the speakers. Both presumed agreement and disagreement will be discussed in terms of how the speakers aim to impose their default perspectives on the addressees. The analysis is based on examples from a substantial corpus of German chancellors’ political speeches from 1951–2001.
Pepper: cytoscape app for protein complex expansion using protein–protein interaction networks
Authors: Winterhalter C. , Nicolle R. , Louis A. , To C. , Radvanyi F. , Elati M. 
Published: August 2014

Abstract
We introduce Pepper (Protein complex Expansion using Protein–Protein intERactions), a Cytoscape app designed to identify protein complexes as densely connected subnetworks from seed lists of proteins derived from proteomic studies. Pepper identifies connected subgraph by using multi-objective optimization involving two functions: (i) the coverage, a solution must contain as many proteins from the seed as possible, (ii) the density, the proteins of a solution must be as connected as possible, using only interactions from a proteome-wide interaction network. Comparisons based on gold standard yeast and human datasets showed Pepper’s integrative approach as superior to standard protein complex discovery methods. The visualization and interpretation of the results are facilitated by an automated post-processing pipeline based on topological analysis and data integration about the predicted complex proteins. Pepper is a user-friendly tool that can be used to analyse any list of proteins.
Availability: Pepper is available from the Cytoscape plug-in manager or online (http://apps.cytoscape.org/apps/pepper) and released under GNU General Public License version 3.
Contact: mohamed.elati@issb.genopole.fr
Supplementary information: Supplementary data are available at Bioinformatics online.