bluuebunny/crossref_metadata_2025_split huggingface dataset:
Annexin-1 regulated by HAUSP is essential for UV-induced damage response
Authors: Park J-J , Lim K-H , Baek K-H 
Published: February 2015

AbstractDNA damage can occur through diverse stimulations such as toxins, drugs, and environmental factors. To respond to DNA damage, mammalian cells induce DNA damage response (DDR). DDR signal activates a rapid signal transduction pathway, regulating the cell fate based on the damaged cell condition. Moreover, serious damaged cells have to be eliminated by the macrophage to maintain homeostasis. Because the DDR induces genomic instability followed by tumor formation, targeting the DDR signaling can be applied for the cancer therapy. Herpes virus-associated ubiquitin-specific protease (HAUSP/USP7) is one of the well-known deubiquitinating enzymes (DUBs) owing to its relevance with Mdm2-p53 complex. The involvement of HAUSP in DDR through p53 led us to investigate novel substrates for HAUSP, which is related to DDR or apoptosis. As a result, we identified annexin-1 (ANXA1) as one of the putative substrates for HAUSP. ANXA1 has numerous roles in cellular systems including anti-inflammation, damage response, and apoptosis. Several studies have demonstrated that ANXA1 can be modified in a post-translational manner by processes such as phosphorylation, SUMOylation, and ubiquitination. In addition, DNA damage gives various functions to ANXA1 such as stress response or cleavage-mediated apoptotic cell clearance. In the current study, our proteomic analysis using two-dimensional electrophoresis, matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry (MALDI-TOF-MS) and nano LC-MS/MS, and immunoprecipitation revealed that ANXA1 binds to HAUSP through its HAUSP-binding motif (P/AXXS), and the cleavage and damage-responsive functions of ANXA1 upon UV-induced DNA damage may be followed by HAUSP-mediated deubiquitination of ANXA1. Intriguingly, the UV-induced damage responses via HAUSP-ANXA1 interaction in HeLa cells were different from the responses shown in the Jurkat cells, suggesting that their change of roles may depend on the cell types.
Ets-1 as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells
Authors: Qiao N , Xu C , Zhu Y-X , Cao Y , Liu D-C , Han X 
Published: February 2015

AbstractHypoxia complicates islet isolation for transplantation and may contribute to pancreatic β-cell failure in type 2 diabetes. Pancreatic β-cells are susceptible to hypoxia-induced apoptosis. Severe hypoxic conditions during the immediate post-transplantation period are a main non-immune factor leading to β-cell death and islet graft failure. In this study, we identified the transcription factor Ets-1 (v-ets erythroblastosis virus E26 oncogene homolog 1) as an early response gene against hypoxia-induced apoptosis in pancreatic β-cells. Hypoxia regulates Ets-1 at multiple levels according to the degree of β-cell oxygen deprivation. Moderate hypoxia promotes Ets-1 gene transcription, whereas severe hypoxia promotes its transactivation activity, as well as its ubiquitin-proteasome mediated degradation. This degradation causes a relative insufficiency of Ets-1 activity, and limits the transactivation effect of Ets-1 on downstream hypoxic-inducible genes and its anti-apoptotic function. Overexpression of ectopic Ets-1 in MIN6 and INS-1 cells protects them from severe hypoxia-induced apoptosis in a mitochondria-dependent manner, confirming that a sufficient amount of Ets-1 activity is critical for protection of pancreatic β-cells against hypoxic injury. Targeting Ets-1 expression may be a useful strategy for islet graft protection during the immediate post-transplantation period.
Capture Hi-C identifies the chromatin interactome of colorectal cancer risk loci
Authors: Jäger Roland , Migliorini Gabriele , Henrion Marc , Kandaswamy Radhika , Speedy Helen E. , Heindl Andreas , Whiffin Nicola , Carnicer Maria J. , Broome Laura , Dryden Nicola , Nagano Takashi , Schoenfelder Stefan , Enge Martin , Yuan Yinyin , Taipale Jussi , Fraser Peter , Fletcher Olivia , Houlston Richard S. 
Published: February 2015

AbstractMultiple regulatory elements distant from their targets on the linear genome can influence the expression of a single gene through chromatin looping. Chromosome conformation capture implemented in Hi-C allows for genome-wide agnostic characterization of chromatin contacts. However, detection of functional enhancer–promoter interactions is precluded by its effective resolution that is determined by both restriction fragmentation and sensitivity of the experiment. Here we develop a capture Hi-C (cHi-C) approach to allow an agnostic characterization of these physical interactions on a genome-wide scale. Single-nucleotide polymorphisms associated with complex diseases often reside within regulatory elements and exert effects through long-range regulation of gene expression. Applying this cHi-C approach to 14 colorectal cancer risk loci allows us to identify key long-range chromatin interactions in cis and trans involving these loci.
Column‐level passive sample and column‐shared active readout structure for high speed, low power ROIC
Authors: Guannan Wang , Wengao Lu , Dahe Liu , Yacong Zhang , Zhongjian Chen 
Published: February 2015

A novel odd–even column‐level passive sample and column‐shared active readout structure is proposed to realise a high speed, low power and low noise readout integrated circuit (ROIC). This structure reduces the number of operational amplifiers (OPAs) in each column and decreases the power consumption of the column capacitive transimpedance amplifier (CTIA) and output buffer. Compared to the traditional design for medium‐scale array ROIC, power consumption of a single column is reduced by 80%. A 320 × 320 array ROIC has been designed for indium antimonide (InSb) cooled infrared detector using the novel structure. The chip is fabricated in the 0.35 μm CMOS process. The total power consumption is <55 mW when operating at 200 Hz frame rate with four outputs and the linearity is 99.95%.
Photocatalytic removal of Rhodamine B using Fe3O4/BiOBr magnetic microsphere under visible‐light irradiation
Authors: Cao Guang Sheng , Wang Gui Long , Bai Yu Jie , Liu Men Xue 
Published: February 2015

A magnetic Fe3O4/BiOBr microsphere has been prepared by a simple and effective method. The Fe3O4/BiOBr magnetic photocatalyst exhibited excellent photocatalytic activity for the degradation of Rhodamine B (RhB) under visible‐light irradiation. RhB in aqueous solution was fully photodegraded after 100 min. The Fe3O4/BiOBr photocatalyst was easily recovered after liquid‐phase photodegradation reaction because of its property, which could facilitate the practical running of an industrial wastewater treatment.
Effects of fast‐velocity eccentric resistance training on early and late rate of force development
Authors: Oliveira Anderson Souza , Corvino Rogério Bulhões , Caputo Fabrizio , Aagaard Per , Denadai Benedito Sérgio 
Published: February 2015

AbstractThis study examined whether short‐term maximal resistance training employing fast‐velocity eccentric knee extensor actions would induce improvements in maximal isometric torque and rate of force development (RFD) at early (<100 ms) and late phases (>100 ms) of rising torque. Twenty healthy men were assigned to two experimental groups: eccentric resistance training (TG) or control (CG). Participants on the TG trained three days a week for a total of eight weeks. Training consisted of maximal unilateral eccentric knee extensors actions performed at 180°s‐1. Maximal isometric knee extensor torque (MVC) and incremental RFD in successive 50 ms time‐windows from the onset contraction were analysed in absolute terms (RFDINC) or when normalised relative to MVC (RFDREL). After eight weeks, TG demonstrated increases in MVC (28%), RFDINC (0–50 ms: 30%; 50–100 ms: 31%) and RFDREL (0–50 ms: 29%; 50–100 ms: 32%). Moreover, no changes in the late phase of incremental RFD were observed in TG. No changes were found in the CG. In summary, we have demonstrated, in active individuals, that a short period of resistance training performed with eccentric fast‐velocity isokinetic muscle contractions is able to enhance RFDINC and RFDREL obtained at the early phase of rising joint torque.
Measuring the Political Salience of Supreme Court Cases
Authors: Clark Tom S. , Lax Jeffrey R. , Rice Douglas 
Published: February 2015

AbstractWhile Supreme Court cases are generally salient or important, some are many degrees more important than others. A wide range of theoretical and empirical work throughout the study of judicial politics implicates this varying salience. Some work considers salience a variable to be explained, perhaps with judicial behavior the explanatory factor. The currently dominant measure of salience is the existence of newspaper coverage of a decision, but decisions themselves are an act of judicial politics. Because this coverage measure is affected only after a decision is announced, using it limits the types of inferences we can draw about salience. We develop a measure of latent salience, one that builds on existing work, but that also explicitly incorporates and models predecision information. This measure has the potential to ameliorate concerns of causal inference, put research findings on sounder footing, and add to our understanding of judicial behavior.
Understanding Judicial Power
Authors: Hall Matthew E. K. , Windett Jason Harold 
Published: February 2015

AbstractHigh courts are widely believed to influence the criminal justice system, yet judicial impact varies widely across political and institutional contexts. Here, we seek to identify the factors that constrain judicial influence on state incarceration rates. We find that the preferences of justices on state courts of last resort and the US Supreme Court influence incarceration; however, high-court impact is conditional on two factors. Judicial influence is stronger in states with divided partisan governments and occurs more quickly in states that lack intermediate appellate courts. Our findings suggest that legislative gridlock and institutional thickness significantly constrain judicial impact.
The Role of Wall Shear Stress in the Assessment of Right Ventricle Hydraulic Workload
Authors: Kheyfets Vitaly , Thirugnanasambandam Mirunalini , Rios Lourdes , Evans Daniel , Smith Triston , Schroeder Theodore , Mueller Jeffrey , Murali Srinivas , Lasorda David , Spotti Jennifer , Finol Ender 
Published: February 2015

Pulmonary hypertension (PH) is a devastating disease affecting approximately 15–50 people per million, with a higher incidence in women. PH mortality is mostly attributed to right ventricle (RV) failure, which results from RV hypotrophy due to an overburdened hydraulic workload. The objective of this study is to correlate wall shear stress (WSS) with hemodynamic metrics that are generally accepted as clinical indicators of RV workload and are well correlated with disease outcome. Retrospective right heart catheterization data for 20 PH patients were analyzed to derive pulmonary vascular resistance (PVR), arterial compliance (C), and an index of wave reflections (Γ). Patient‐specific contrast‐enhanced computed tomography chest images were used to reconstruct the individual pulmonary arterial trees up to the seventh generation. Computational fluid dynamics analyses simulating blood flow at peak systole were conducted for each vascular model to calculate WSS distributions on the endothelial surface of the pulmonary arteries. WSS was found to be decreased proportionally with elevated PVR and reduced C. Spatially averaged WSS (SAWSS) was positively correlated with PVR (R2 = 0.66), C (R2 = 0.73), and Γ (R2 = 0.5) and also showed promising preliminary correlations with RV geometric characteristics. Evaluating WSS at random cross sections in the proximal vasculature (main, right, and left pulmonary arteries), the type of data that can be acquired from phase‐contrast magnetic resonance imaging, did not reveal the same correlations. In conclusion, we found that WSS has the potential to be a viable and clinically useful noninvasive metric of PH disease progression and RV health. Future work should be focused on evaluating whether SAWSS has prognostic value in the management of PH and whether it can be used as a rapid reactivity assessment tool, which would aid in selection of appropriate therapies.
Isoperimetric inequalities in Euclidean convex bodies
Authors: Ritoré Manuel , Vernadakis Efstratios 
Published: February 2015

In this paper we consider the problem of minimizing the relative perimeter under a volume constraint in the interior of a convex body, i.e., a compact convex set in Euclidean space with interior points. We shall not impose any regularity assumption on the boundary of the convex set. Amongst other results, we shall prove that Hausdorff convergence in the space of convex bodies implies Lipschitz convergence, the continuity of the isoperimetric profile with respect to the Hausdorff distance, and the convergence in Hausdorff distance of sequences of isoperimetric regions and their free boundaries. We shall also describe the behavior of the isoperimetric profile for small volume and the behavior of isoperimetric regions for small volume.
Characteristics and Prognosis of Allergic Proctocolitis in Infants
Authors: Kaya Aysenur , Toyran Muge , Civelek Ersoy , Misirlioglu Emine , Kirsaclioglu Ceyda , Kocabas Can N. 
Published: February 2015

ABSTRACTObjectives:The dietary protein proctocolitis, also known as allergic proctocolitis (AP), is characterized by the presence of mucoid, frothy, and bloody stools in an otherwise healthy infant. The aim of this study was to describe a group of children with AP, diagnosed according to the criterion‐standard method, food challenge to provide clinicians with more information on typical presentation, and an overview on nutritional management strategies and prognosis.Methods:We collected data on infants with AP in our allergy and gastroenterology outpatient clinics. Any other conditions that may cause bloody diarrhea were ruled out. Skin prick tests and atopy patch tests were performed for diagnosis, and patients were studied for resolution. To the patients whose rectal bleeding did not recover with oligoantigenic maternal diet in addition to amino acid–based formula, endoscopic evaluation was performed to confirm the diagnosis and to exclude other reasons of rectal bleeding.Results:Sixty patients were diagnosed as having AP. The age of onset was 1.7 ± 1.32 months. All of the patients were triggered by milk, 6.6% with milk and egg, 3.3% with milk and chicken, 1.7% with milk and wheat, 1.7% with milk and potato, and 3.3% had multiple food allergy. 53.3% (n = 32) acquired tolerance by age 1, 25.0% (n = 15) by 2 years, 5% (n = 3) by 3, and 1.7% (n = 1) by 4 years.Conclusions:Milk was a triggering factor for all of the patients. Resolution of AP is usually within 1 year but symptoms of some patients may continue even longer. An extension of the follow‐up period is required according to our study.
Knowledge and Practices of Pediatricians Regarding Functional Constipation in the State of Minas Gerais, Brazil
Authors: Torres Marcia R.F. , de Melo Maria do Carmo B. , Purcino Flávia A.C. , Maia Joana C. , Aliani Natália A. , Rocha Henrique C. 
Published: February 2015

ABSTRACTObjectives:The aim of the study was to analyze the knowledge, approaches, and practices of pediatricians participating in a regional pediatric conference regarding functional constipation (FC) to identify knowledge gaps.Methods:Cross‐sectional regional study based on a semistructured questionnaire related to the Rome III criteria and the participant profiles.Results:Of 400 questionnaires distributed, 264 (66.0%) were completed. Most pediatricians (76.7%) did not recognize the Rome III criteria, but the majority did recognize the following risk factors for FC: low‐fiber diet (97.8%), family history (86.6%), onset of toilet training (76.4%), and weaning (62.4%). Foods considered high in fiber were oats (95.7%), leafy vegetables (95.3%), and wheat bran (93.2%). Digital rectal examination was not performed by 57.7% of nongastroenterologists. Complementary examinations were ordered in 27.5% and 72.5% of patients by general pediatricians and pediatric gastroenterologists, respectively, although the sample of gastroenterologists was not representative. The most prescribed drugs by nongastroenterologists were mineral oil (72.6%), magnesium hydroxide (52.1%), lactulose (41.0%), and polyethylene glycol (25.2%). Pediatric gastroenterologists prescribed magnesium hydroxide (91.7%), polyethylene glycol (91.7%), and mineral oil (58.3%). Most pediatricians (70.0%) considered the average treatment duration to be less than 1 year, although gastroenterologists considered it to be more than 1 year (54.6%).Conclusions:The knowledge of pediatricians regarding FC is inadequate. Constipation may not receive the public health attention it deserves within pediatric residency programs. The authors suggest that better education regarding FC should be included in medical school and residency program curricula to improve patient care.
Aortic Intima‐Media Thickness as an Early Marker of Atherosclerosis in Children With Inflammatory Bowel Disease
Authors: Aloi Marina , Tromba Luciana , Rizzo Valentina , D'Arcangelo Giulia , Dilillo Anna , Blasi Sara , Civitelli Fortunata , Kiltzanidi Dimitra , Redler Adriano , Viola Franca 
Published: February 2015

ABSTRACTObjectives:The aims of this study were to determine the presence of endothelial dysfunction by measuring aortic intima‐media thickness (aIMT) and carotid intima‐media thickness (cIMT) and to evaluate the role of traditional risk factors for premature atherosclerosis in children with inflammatory bowel disease (IBD).Methods:Thirty‐four children with IBD (25 Crohn disease [CD] and 9 ulcerative colitis [UC]; mean age 11.1 years) and 27 healthy subjects matched for sex and age were enrolled. In all of the patients, demographic characteristics and risk factors for atherosclerosis (age, sex, body mass index, blood pressure, dyslipidemia, active and passive smoking, and family history for cardiovascular diseases), CD and UC clinical activity scores, and inflammatory markers were evaluated. aIMT and cIMT were measured by high‐resolution B‐mode ultrasound.Results:aIMT was significantly higher in patients than in controls (P < 0.0005). No significant differences were found for cIMT, although the carotid thickness was higher in patients with IBD than in healthy subjects. At a univariate analysis, inflammatory markers levels and tobacco smoking exposure were significantly related to higher aIMT values, whereas in a multivariate regression model, the inflammatory status was the only independent variable correlated with high aIMT.Conclusions:aIMT is an earlier marker of preclinical atherosclerosis than cIMT in young children with active IBD. The inflammatory status and the smoking exposure are significantly correlated with the premature endothelial dysfunction. These data emphasize the importance of controlling the chronic intestinal inflammation and endorsing smoke‐free environments for children and adolescents with IBD.
Primary Care Follow-up After Emergency Department Visits for Routine Complaints
Authors: Chen Jessica , Singer Eric 
Published: February 2015

Objectives
Given that the vast majority of pediatric patients that present to the emergency department (ED) are discharged home after their visit, one issue for study is the appropriate recommendations for follow-up after the ED visit. Numerous PubMed searches using various keywords revealed a gap in the literature regarding the desires of primary care physicians (PCPs) concerning follow-up after ED visits. This study was conducted to determine how pediatric emergency medicine (PEM) physicians' recommendations for follow-up align with the desires of (PCPs) for follow-up after ED visits.

Methods
An electronic survey was distributed to pediatric emergency physicians at one community-based academic institution regarding current recommendations for follow-up with PCPs for 12 common diagnoses seen in the ED. A similar survey was sent to pediatricians in the same community inquiring about their desires for follow-up after their patients are seen in the ED for the same diagnoses.

Results
Completion rates for the survey were 40/40 (100%) for PEM physicians and 78/145 (54%) for pediatricians. In 11/12 of the diagnoses included, PEM physicians recommended a statistically significant (P < 0.05) closer follow-up than desired by the PCPs.

Conclusions
Recommendations for follow-up made by PEM physicians and desired by PCPs vary significantly. Overall, PEM physicians recommend closer follow-up than desired by PCPs for low acuity complaints. Closing of this gap may allow for a better allocation of resources and consistency of care.
Size-dependent energy in crystal plasticity and continuum dislocation models
Authors: Mesarovic Sinisa Dj. , Forest Samuel , Jaric Jovo P. 
Published: February 2015

In the light of recent progress in coarsening the discrete dislocation mechanics, we consider two questions relevant for the development of a mesoscale, size-dependent plasticity: (i) can the phenomenological expression for size-dependent energy, as quadratic form of Nye's dislocation density tensor, be justified from the point of view of dislocation mechanics and under what conditions? (ii) how can physical or phenomenological expressions for size-dependent energy be computed from dislocation mechanics in the general case of elastically anisotropic crystal? The analysis based on material and slip system symmetries implies the negative answer to the first question. However, the coarsening method developed in response to the second question, and based on the physical interpretation of the size-dependent energy as the coarsening error in dislocation interaction energy, introduces additional symmetries. The result is that the equivalence between the phenomenological and the physical expressions is possible, but only if the multiplicity of characteristic lengths associated with different slip systems, is sacrificed. Finally, we discuss the consequences of the assumption that a single length scale governs the plasticity of a crystal, and note that the plastic dissipation at interfaces has a strong dependence on the length scale embedded in the energy expression.