bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ultrasound‐guided caudal cervical articular process arthrocentesis is accurate in live horses with and without arthropathy
Authors: Davidson Elizabeth J. , Stefanovski Darko , Slack Joann , Manzi Timothy J. 
Published: July 2024

AbstractBackgroundCervical articular process joint (CAPJ) therapy is advocated for horses with neck disorders. Several ultrasound‐guided CAPJ techniques have been described in cadaver studies with 72%–89% intra‐articular injection accuracy; however, the CAPJ injection accuracy in clinical equine practice has not been extensively reported.ObjectivesTo describe a modified cranial approach for ultrasound‐guided caudal CAPJ injections, to investigate the accuracy of this CAPJ injection technique in live horses, and to assess the effect of CAPJ injection location, laterality, operator, and radiographic CAPJ enlargement on injection accuracy.Study designRetrospective case study.MethodsMedical records of adult horses in which ultrasound‐guided caudal (C4–T1) CAPJ injections were performed using a modified cranial approach between November 2006 and December 2020 were reviewed. Radiographic images of caudal cervical vertebrae were assessed by a blinded radiologist and the degree of CAPJ enlargement was graded using a previously described grading system (Rgrade 1‐5b). Ultrasound‐guided caudal CAPJ injection accuracy was determined by synovial fluid retrieval during an individual CAPJ injection. Statistical analysis was performed using mixed‐effects multivariable logistic model to evaluate the association of CAPJ injection accuracy and the CAPJ injection location, Rgrade, laterality (right, left), and operator.ResultsThe study included 149 horses with 177 hospital admissions. Synovial fluid was obtained from 586/658 (89.1%) caudal CAPJs using modified cranial ultrasound‐guided approach for CAPJ injections. C6–C7 CAPJ injections had 7‐fold higher likelihood (OR = 6.78, 95% CI: 1.67–27.52; p = 0.007) of synovial fluid retrieval compared with C4–C5 CAPJ injections. Operator, CAPJ injection side (left, right), and degree of radiographic CAPJ enlargement did not have significant effects on the success of synovial fluid retrieval from ultrasound‐guided caudal CAPJ injections.Main limitationsRetrospective study design.ConclusionsIntra‐articular ultrasound‐guided caudal CAPJ injections using a modified cranial approach can be performed accurately in live horses with and without CAPJ arthropathy.
Antimicrobial Resistance of Helicobacter pylori Isolated From Latin American Children and Adolescents (2008–2023): A Systematic Review
Authors: Cabrera Camila , Torres Joaquín , Serrano Carolina A. , Gallardo Paulina , Orellana Vicente , George Sergio , O'Ryan Miguel , Lucero Yalda 
Published: July 2024

ABSTRACTBackgroundLatin America has a high prevalence of Helicobacter pylori in children that may lead to peptic ulcer disease and eventually gastric cancer in adulthood. Successful eradication is hindered by rising antimicrobial resistance. We summarize H. pylori resistance rates in Latin American children from 2008 to 2023.Material and MethodsSystematic review following PRISMA guidelines and National Heart, Lung, and Blood Institute checklist to assess risk of bias (PROSPERO CRD42024517108) that included original cross‐sectional observational studies reporting resistance to commonly used antibiotics in Latin American children and adolescents. We searched in PubMed, LILACS, and SciELO databases.ResultsOf 51 studies, 44 excluded studies. The quality of the seven analyzed studies (297 H. pylori‐positive samples) was satisfactory. Phenotypic methods (N = 3) reported higher resistance rates than genotypic studies (N = 3). Clarithromycin resistance ranged from 8.1% to 79.6% (7 studies, 346 samples), metronidazole from 1.9% to 40.2% (4 studies; 211 samples), amoxicillin from 0% to 10.4% (3 studies; 158 samples), tetracycline resistance was not detected (3 studies; 158 samples), and levofloxacin resistance was 2.8% (1 study; 36 samples). [Correction added on 24 October 2024, after first publication: In the Results paragraph, the number of excluded studies has been updated; the number of analyzed studies has been updated; and the percentage and number of studies and samples for Clarithromycin resistance updated.]ConclusionScarce Latin American studies on H. pylori resistance, along with methodological heterogeneity, hinder conclusive findings. Clarithromycin and metronidazole (first‐line drugs) resistance is worrisome, likely impacting lower eradication rates. Urgent systematic surveillance or individual testing before treatment is necessary to enhance eradication.
Ten Priorities for Research Addressing the Intersections of Brain Injury, Mental Health and Addictions: A Stakeholder‐Driven Priority‐Setting Study
Authors: Kennedy Cole J. , Woodin Erica , Schmidt Julia , Biagioni Janelle Breese , Garcia‐Barrera Mauricio A. 
Published: July 2024

ABSTRACTObjectivesThe purpose of this study was to engage key stakeholders in a health research priority‐setting process to identify, prioritize and produce a community‐driven list of research questions addressing intersectional issues on mental health and addictions (MHA) in acquired brain injury (ABI).MethodsA multiphasic health research priority‐setting process was co‐designed and executed with community‐based stakeholders, including researchers, health professionals, clinicians, service providers, representatives from brain injury associations, policy makers and people with lived experience of ABI and MHA, including patients and their family members. Stakeholders' ideas led to the generation of research questions, which were prioritized at a 1‐day workshop.ResultsFifty‐nine stakeholders participated in the priority‐setting activity during the workshop, which resulted in a rank‐ordered list of the top 10 questions for research addressing the intersections of ABI and MHA. Questions identified touched on several pressing issues (e.g., opioid crisis, homelessness), encompassed multiple subtypes of ABI (e.g., hypoxic‐ischaemic, mild traumatic), and involved different domains (e.g., identification, intervention) of health research.ConclusionsThis community‐driven health research priority‐setting study identified and prioritized research questions addressing the intersections of ABI and MHA. Researchers and funding agencies should use this list to inform their agendas and address stakeholders' most urgent needs, fostering meaningful improvements to clinical services.Patient or Public ContributionAn 11‐person working group comprised of people with lived experience, service providers, researchers, healthcare professionals and other key stakeholders collaboratively developed and informed the scope, design, methodology and interpretation of this study. Over 50 community‐based stakeholders contributed to the research priority‐setting activity. One co‐author is a person with lived experience.
Validity and reliability of the Turkish version of the Ostomy Self‐Care Index
Authors: AVCU Çağla , Yildiz Tülin 
Published: July 2024

AbstractAlthough stoma is often life‐saving, evacuation outside of natural ways and changes in body image negatively affect the quality of life of the individual. To our knowledge, there is no Turkish scale that evaluates the self‐care of individuals with a stoma. This study aimed to examine the validity and reliability of the Ostomy Self‐Care Index in Turkish. This is a methodological study. The study sample consisted of 253 individuals with ostomy. ‘Ostomy Individual Information Form’ and ‘Ostomy Self‐Care Index’ were used as data collection tools. Data were collected between September 2020 and January 2021 through face‐to‐face interviews conducted at two public hospitals in Turkey. In the analysis of the data, descriptive statistics, language and content validity, confirmatory factor analysis, item analysis, internal consistency and test–retest methods were used. The content validity index was 0.99, and Cronbach's alpha was 0.949. According to confirmatory factor analysis, the goodness of fit indices were at the desired level, the factor loads of the items were between 0.575 and 0.964, and all items were included in eight sub‐dimensions in line with the original scale. As in the original version of the scale, item 18, which was not statistically significant, was excluded in the analysis and was accepted as an addition. The correlation of scale items in the test–retest was between 0.837 and 0.988. This study determined that the Ostomy Self‐Care Index is valid and reliable for measuring the self‐care of stoma patients in Turkey. This scale can be used as a guide for evaluating the self‐care of individuals with a stoma and planning their care.
Governing digital platform ecosystems for social options
Authors: Sanner Terje Aksel , Kempton Alexander Moltubakk , Russpatrick Scott , Sæbø Johan Ivar 
Published: July 2024

AbstractTo date, there is little insight into how digital platforms might be governed towards the creation of social value. We argue that digital platforms can contribute to the creation of social value by enabling social options. Thus, we are concerned about how digital platform ecosystems may be governed towards the enablement of social options. We report on the results from our longitudinal qualitative case study of a digital platform employed by ministries of health in more than 70 low‐ and middle‐income countries. We trace the formation and subsequent shaping of governance mechanisms employed to enable social options across national borders and domains. We develop a model of platform governance that shows how such mechanisms are shaped over time through resourcing, capacitating and purposing processes. These three processes play distinct yet complementary roles in governing for social options.
Implementing early childhood care and education policies for marginalized children: The challenge of conflicting interests among diverse governing bodies and local actors in Sri Lanka
Authors: Udayanga Samitha 
Published: July 2024

AbstractThe present study aimed to investigate how the presence of diverse governing bodies and local actors with conflicting interests hinders the implementation of early childhood care and education (ECCE) policies, resulting in the exclusion of children from ECCE programmes in the plantation sector, one of the most marginalized social sectors in Sri Lanka. The research employed a qualitative case study design, collecting data through in‐depth interviews (N = 29) and two focus‐group discussions. The thematic analysis revealed that child development outcomes in the estate/plantation sector are at risk primarily due to exclusion of children from ECCE programmes caused by conflicts between local governing bodies and local actors, which impede partnerships for policy implementation. The conflicting interests of diverse governing bodies and local actors at the community level act as a filter through which government‐proposed ECCE programmes are reinterpreted and ultimately rejected. The implications of the present study thus suggest that despite the restraining influence of local governing bodies and local actors, there is a potential for participatory governance that can foster collaboration between government institutions, local‐level governing bodies and local actors.
Diabetic foot self‐care knowledge and practice among patients with diabetes attending diabetic clinic in the Gambia
Authors: Omotosho Tobiloba Oyejide Alex , Sanyang Yusupha , Senghore Thomas 
Published: July 2024

AbstractDiabetic foot ulcer is the most common complication causing lots of admissions among diabetic patients. Understanding patients' level of foot self‐care knowledge, practice and associated factors is important for planning interventions to control and prevent diabetic foot complications. This study aimed to assess the level of knowledge and practice of foot self‐care among diabetic patients attending diabetic clinics in The Gambia. Two hundred and seventeen patients attending diabetic clinics in two public hospitals were selected using a successive sampling technique. Data were collected using a validated interviewer‐administered questionnaire. Descriptive statistics were used to summarize the demographic and clinical data. Multivariate logistic regression was used to identify factors associated with foot self‐care knowledge and practice. The findings showed a poor level of foot self‐care knowledge (n = 114; 52.5%) and practice (n = 149; 68.7%). Patients' educational level was statistically significantly association with diabetic foot self‐care knowledge (p = 0.02). Diabetic foot ulcer history (aOR = 0.23, 95% CI: 0.08–0.63; p < 0.001), diabetic hospitalization (aOR = 2.41, 95% CI: 1.23–4.75, p = 0.01) and diabetic foot care education (aOR = 2.65, 95% CI: 1.39–5.06, p < 0.001) were statistically significantly associated with foot self‐care practice. The poor diabetic foot self‐care knowledge and practice among these patients emphasize the need for a diabetic health education program in these clinics.
Supporting the nutrition‐related health and well‐being of people experiencing socio‐economic disadvantage: Findings from a national survey
Authors: Vaiciurgis Verena T. , Clancy Annabel K. , Charlton Karen E. , Stefoska‐Needham Anita , Beck Eleanor J. 
Published: July 2024

AbstractBackgroundPeople experiencing socio‐economic disadvantage face significantly higher rates of diet‐related health inequities. This study aimed to explore barriers, opportunities and potential solutions in providing food and nutrition services to people experiencing socio‐economic disadvantage from the perspective of services providers. The present study is part of a broad co‐design model to improve service provision for people experiencing socio‐economic disadvantage.MethodsA cross‐sectional online survey involving 33 open and closed‐ended questions was distributed to Australian governmental and non‐governmental organisations providing nutrition‐related support to people experiencing socio‐economic disadvantage aged 16 years and over. Data were analysed using frequency distributions and conceptual content analyses.ResultsSixty‐eight responses were analysed. Services are predominantly offered by charitable organisations (90%), funded through private donations (66%) and reliant on volunteers (100%). Barriers to supporting clients’ nutrition needs include financial constraints, limited community engagement, understaffing, insufficient resources and knowledge gaps. Opportunities and solutions for enhancing support include increasing government funding, advocacy initiatives, stronger community collaboration and more holistic, customised services. Proposed recommendations include establishing purpose‐built facilities or wrap‐around services to expand access to health services, life skills, training and educational programs.ConclusionsServices face challenges including volunteer reliance, limited resources and inadequate government support, hindering food provision. Client barriers include transportation costs and lack of social support. With dedicated financial support, services can offer comprehensive assistance, including community spaces, staffing, health and social services and training. Community partnerships can maximise funding impact. Solutions must address overall well‐being and broader social determinants such as income inequality and housing.
Areas of endemism of the orchids of Megamexico: Hotspots of biotic interactions with pollinators
Authors: Gutiérrez–Rodríguez Brandon E. , Dáttilo Wesley , Villalobos Fabricio , Sosa Victoria 
Published: July 2024

AbstractEcological interactions and evolutionary processes in areas of endemism remain little studied despite the fact that identifying the patterns of functional signatures in areas of endemism could reveal important information regarding community assembly and functioning. Here, we investigated whether areas of endemism of the orchids of Megamexico are hotspots of biotic interactions by comparing the orchid–pollinator interactions with those of adjacent areas. Patterns of functional signatures and phylogenetic signal were estimated, using pollination syndromes as a proxy for functional attributes. Phylogenetic signal was estimated by coding pollinator groups for every orchid recorded. Metrics of the interaction networks and the phylogenetic signal were compared with those obtained from adjacent areas. Our results indicate that areas of endemism show higher significant differences in the phylogenetic signal compared with adjacent areas. This can be explained by the many distantly related orchid lineages sharing attributes related to pollination. Network size and robustness differed statistically between the areas of endemism and the adjacent areas. The same configuration of modules in interaction networks was found in the areas of endemism; however, remarkably, the composition of species in large genera differed in these areas. Areas of endemism harbor more orchid lineages that closely interact with many groups of insects. The southerly areas of endemism in Chiapas and Central America are prominent, with the most significant phylogenetic signal and networks metrics. Results indicate that areas of endemism for the orchids of Megamexico represent hotspots of biotic interactions. Strategies for conservation must take this biotic interaction into account.
Characteristics and Activities of Nurses in Expanded Roles Employed in Swiss Nursing Homes: A Cross‐Sectional Study
Authors: Saladino Christian , Favez Lauriane , Serdaly Christine , Ausserhofer Dietmar , De Geest Sabina , Zúñiga Franziska 
Published: July 2024

ABSTRACTBackgroundAs the number of nursing home residents with multiple healthcare needs grows, the demand for nursing expertise increases. The implementation of new care models involving nurses with expanded roles is crucial for ensuring quality care in nursing homes.ObjectivesTo investigate the characteristics and activities of nurses employed in nursing homes in expanded roles and the factors associated with variation in the activities performed.MethodsThis multicentre cross‐sectional survey in Switzerland collected data from a convenience sample of 118 nursing homes between September 2018 and October 2019. From a subsample of 62 nursing homes, we analysed the characteristics and activities of 104 nurses in expanded roles. Associations between the activities performed and the educational background of the nurses in expanded roles, their direct supervisors' positions and the presence of physicians in the nursing homes were examined.ResultsMost Registered Nurses in expanded roles were diploma educated (48%), with fewer having a bachelor's (35%) or master's degree (17%). Overall, direct clinical practice and guidance and coaching activities were conducted monthly to weekly; consultation, evidence‐based practice, collaboration and ethical decision‐making activities were conducted monthly. We saw variations where a higher educational background was associated with more frequent evidence‐based practice activities (z = 3.47, p < 0.001), and if direct supervisors were ward managers, nurses in expanded roles worked more frequently below their scope of practice (z = 4.10, p < 0.001).ConclusionThis is the first study to use Hamric's integrative Advanced Practice Nursing model to examine the activities of nurses in expanded roles in nursing homes. We found considerable variation in their activities, where nursing homes seem to adapt their roles to their educational background and the local context.Implications for PracticeOur findings show the importance of clarifying role expectations for Registered Nurses in expanded roles, allowing them to practice at the top of the licence to meet residents' complex healthcare needs.
Inhibitory control of gait initiation in humans: An electroencephalography study
Authors: Ziri Deborah , Hugueville Laurent , Olivier Claire , Boulinguez Philippe , Gunasekaran Harish , Lau Brian , Welter Marie‐Laure , George Nathalie 
Published: July 2024

AbstractResponse inhibition is a crucial component of executive control. Although mainly studied in upper limb tasks, it is fully implicated in gait initiation. Here, we assessed the influence of proactive and reactive inhibitory control during gait initiation in healthy adult participants. For this purpose, we measured kinematics and electroencephalography (EEG) activity (event‐related potential [ERP] and time‐frequency data) during a modified Go/NoGo gait initiation task in 23 healthy adults. The task comprised Go‐certain, Go‐uncertain, and NoGo conditions. Each trial included preparatory and imperative stimuli. Our results showed that go‐uncertainty resulted in delayed reaction time, without any difference for the other parameters of gait initiation. Proactive inhibition, that is, Go uncertain versus Go certain conditions, influenced EEG activity as soon as the preparatory stimulus. Moreover, both proactive and reactive inhibition influenced the amplitude of the ERPs (central P1, occipito‐parietal N1, and N2/P3) and theta and alpha/low beta band activities in response to the imperative—Go‐uncertain versus Go‐certain and NoGo versus Go‐uncertain—stimuli. These findings demonstrate that the uncertainty context; induced proactive inhibition, as reflected in delayed gait initiation. Proactive and reactive inhibition elicited extended and overlapping modulations of ERP and time‐frequency activities. This study shows the protracted influence of inhibitory control in gait initiation.
A prospective study of the proteome of equine pre‐implantation embryo
Authors: Teles Filho Antônio Carlos de A. , Sanchez Deisy J. D. , Viana Arabela G. A. , Sheheryar Sheheryar , Guerreiro Denise D. , Bustamante‐Filho Ivan C. , Martins Aline M. A. , Sousa Marcelo V. , Ricart Carlos A. O. , Fontes Wagner , Moura Arlindo A. 
Published: July 2024

AbstractThe present study was conducted to investigate the global proteome of 8‐day‐old equine blastocysts. Follicular dynamics of eight adult mares were monitored by ultrasonography and inseminated 24 h after the detection of a preovulatory follicle. Four expanded blastocysts were recovered, pooled, and subjected to protein extraction and mass spectrometry. Protein identification was conducted based on four database searches (PEAKS, Proteome Discoverer software, SearchGUI software, and PepExplorer). Enrichment analysis was performed using g:Profiler, Panther, and String platforms. After the elimination of identification redundancies among search tools (at three levels, based on identifiers, peptides, and cross‐database mapping), 1977 proteins were reliably identified in the samples of equine embryos. Proteomic analysis unveiled robust metabolic activity in the 8‐day equine embryo, highlighted by an abundance of proteins engaged in key metabolic pathways like the TCA cycle, ATP biosynthesis, and glycolysis. The prevalence of chaperones among highly abundant proteins suggests that regulation of protein folding, and degradation is a key process during embryo development. These findings pave the way for developing new strategies to improve equine embryo media and optimize in vitro fertilization techniques.