bluuebunny/crossref_metadata_2025_split huggingface dataset:
Development of national specialization in 5G technologies within the European Union
Authors: Rastvortseva Svetlana , Kameneva Elena 
Published: August 2024

AbstractNowadays the efforts of not only companies, but also governments in different countries are aimed at the development of 5G technologies. On the one hand, the introduction of 5G is an expensive process that requires investments in the development, deployment and maintenance of infrastructure, the involvement of a large number of market participants and service providers, the creation of a stimulating and regulatory legislative framework, the provision of radio frequencies of a more efficient spectrum, the solution of patenting issues. On the other hand, the introduction of 5G technologies will be aimed at developing the economy of many industries, creating social benefits, reducing energy intensity, and will create new opportunities for companies. Currently, the benefits of the digital economy can be most used by the United States, the Republic of Korea and China, which have the highest rates of 5G adoption in the world. The countries of the European Union are also interested in the development of 5G technologies. We analysed key 5G technologies for 74,940 related patents for 23 EU countries for the period 2012–2021. It is shown that the leaders in the number of 5G patents were Sweden, Germany, Finland, France, the Netherlands and Ireland. It is noteworthy that countries can either focus on developing a small number of technologies, or develop a wide range of them. Since 2018, France, Estonia and Germany demonstrate the greatest number of technological specializations primarily creating inventions related to 5G data processing. At the same time, the USA, the Republic of Korea and China still retain their competitive advantages in fields of basic electric elements and electric communication technique for fifth generation networks. To improve positions in the global technology market the EU countries need to specialize in rarer and more complex technologies and develop national policies in this area.
Correlation between gut microbiota characteristics and non-small cell lung cancer based on macrogenomics sequencing
Authors: Zeng GuiLin , Zeng LiRong , Wang Ying , Cao Zhi , Zeng XiangHua , Xue ZhiHong , Liu ShiLan , Li YaMao , He Lang 
Published: August 2024

Abstract
Objective
Non-small cell lung cancer (NSCLC) patients undergoing chemotherapy and immunotherapy experience disturbances in the gut microbiota. This study intends to find out the correlation between gut microbiota and clinical indices before and after radiotherapy for NSCLC.

Methods
Ten patients with primary NSCLC were screened, and plasma and fecal samples were collected before and after radiotherapy, respectively. Inflammatory indices in plasma were detected. Genomic DNA was extracted from fecal specimens and sequenced on on Illumina HiSeq2000 sequencing platform. Thee sequenced data were subjected to Metagenome assembly, gene prediction, species annotation, and gene function analysis to study and analyze gut microbiota and metabolic functions. The correlation between the diversity of gut microbiota and the clinical indicators of NSCLC patients was evaluated, and the changes of gut microbiota before and after radiotherapy were observed.

Results
The diversity of gut microbiota in NSCLC patients did not correlate with smoking, pathology, and inflammatory markers. The abundance of phylum (p)_Bacteroidetes increased; p_Firmicutes and p_Bacteroidetes accounted for the highest proportion in NSCLC patients, and the abundance of both was dominantly exchanged after radiotherapy. There was a decrease in genus (g)_Bifidobacterium after radiotherapy in NSCLC patients. There was no significant correlation between the diversity of gut microbiota after radiotherapy and radiotherapy sensitivity, and the structural composition and abundance of gut microbiota remained stable.

Conclusion
The diversity of gut microbiota is altered after radiotherapy in NSCLC patients, showing an increase in harmful bacteria and a decrease in beneficial bacteria.
The celebrity effect on gaze following in older and young adults
Authors: Chen Airui , Yuan Zhaojun , Zhou Sihan , Yu Qingqing , Zhang Fangyuan , Dong Bo 
Published: August 2024

Abstract
Background
In daily life, people often follow others’ gaze direction to infer their attention and mental state. This phenomenon is known as gaze following.

Objective
This study aimed to explore whether gaze following in different age groups is influenced by celebrity identity.

Methods
We recruited 70 participants, including 35 older adults and 35 young adults. The experimental materials consisted of three faces with different identity information (a political leader, a movie star, and an ordinary person). Each face had left and right gaze conditions. Targets and cues were presented with both longer and shorter stimulus onset asynchrony (SOA) conditions.

Results
Both older adults and young adults exhibited similar gaze following behaviors. Importantly, the celebrity effect on gaze following was observed in both groups, with stronger effects induced by the leader’s and star’s gazes compared to the ordinary person’s gaze. Older adults showed a larger facilitation effect under the longer SOA condition compared to the shorter SOA, while no such SOA-related facilitation effect was found for young adults.

Conclusion
These findings suggest that older adults can integrate social information from others’ faces (celebrity identity) into the process of gaze following as effectively as young adults.
Lowering vector competence in insects: a review
Authors: Olagunju Emmanuel Ajibola 
Published: August 2024

Abstract
Background
Insects act as disease vectors, spreading disease-causing organisms between plants and animals. There have been studies devoted to determining ways to control these pests. One of the most effective ways to accomplish this is to reduce their vector competency. This review article explains how these factors can reduce vector competency.

Main body
The major ways by which vector competence can be reduced were reviewed. Entomopathogens are organisms that cause disease in arthropods like insects, mites, and ticks. Wolbachia is a genus of intracellular bacteria that mostly infects arthropods, including a significant number of insects. It is one of the most frequent insect reproductive parasites that kill or severely disables insects. Entomopathogenic nematodes are a type of worm that attacks insects and kills them. Insect-specific viruses are a relatively new class of viruses with a variety of intriguing traits that could be used to better understand and possibly inhibit arbovirus transmission. Entomopathogenic fungi are a type of fungus that kills insects by attacking and infecting their insect hosts. Disrupting the environment and nutrition of insects could also help to reduce their ability to spread diseases to humans, animals, and plants.

Conclusions
Chemical control has been one of the most widely used methods for controlling disease vectors, but there have been reports of insect resistance, environmental degradation, and a variety of other side effects. Instead of chemical control, there are a variety of techniques that can be used, including targeting insects' endosymbionts (bacteria, viruses, fungi, nematodes, and protozoa), changing insects' nutrition, manipulating their environment, and many others. This paper discussed the alternative ways to reduce vectors’ competence without the use of synthetic chemical.
Effect of nano-fluorapatite filler particles on surface microhardness and mineralization capacity of an experimental oral film
Authors: Zaki Dalia Y. , Safwat Engie M. , Salem Haidy N. , Nagi Shaymaa M. , Hamdy Tamer M. , Moharam Lamiaa M. , Hassan Mohammad L. , Sherief Marwa A. 
Published: August 2024

Abstract
Background
The objective of the study was to prepare and assess novel remineralizing oral films loaded with fluorapatite powder and composed of a combination of hydroxyethyl cellulose (HC) and cellulose nanofibers (CF).

Methods
Three concentrations of the prepared nano-fluorapatite were tried and tested after loading in the cellulose blends and films were prepared using solvent cast technique. Along with SEM, measurements of thickness of film, bending tolerance, time of disintegration, surface pH and release of ions were made. The produced film’s ability to remineralize demineralized teeth in vitro was investigated.

Results
The findings showed that the films’ thicknesses were uniform, their folding endurance exceeded 300, and their disintegration times exceeded 24 h. High amounts of fluoride and calcium ions were released, and nearly neutral pH values were observed. The distribution of fluorapatite powder particles was uniform, as demonstrated by SEM. The Vickers microhardness (VHN) of enamel and morphological analysis results showed that in comparison with the demineralized specimens, there was a substantial microhardness value increase following 15 and 30 days remineralization.

Conclusions
Newly developed prepared films are a successful method for remineralizing early-stage demineralized tooth lesions.
How bureaucracies interact with Indigenous Fire Stewardship (IFS): a conceptual framework
Authors: Nikolakis William , Ross Russell Myers , Steffensen Victor 
Published: August 2024

Abstract
Background
Indigenous Fire Stewardship (IFS) is contested within settler-colonial contexts, where its development is shaped by complex and dynamic socio-cultural, legal, and political factors. This manuscript draws from the policy sciences to sketch out a “zone of interaction” between IFS and the state’s wildfire policy system. Drawing from the strategies of bureaucracies, our goal is to illustrate the patterns in this “zone of interaction,” and to identify the implications for IFS, as well as for Indigenous Peoples and landscapes.

Results
Drawing insights from the Australian and Canadian contexts where governments are restoring lands and reconciling with the laws and governance of Indigenous Peoples, we illustrate how IFS interacts with the state. We do this in two ways. Figure 1 shows that the state has three general strategies for dealing with IFS: avoidance (ignoring IFS), coping strategies (carefully considering and sometimes accommodating IFS), and learning (embracing and accommodating IFS). We document that post-wildfire, there are affective drivers that move the state’s approach from avoidance to learning; however, over time, as public attention shifts away from alternatives, the strategy moves back to either avoidance or coping strategies (where the state is required to engage with IFS, but cannot fully embrace it because of institutional, tenure, or jurisdictional issues, among other constraints). Figure 2 documents the six coping strategies available to bureaucracies in dealing with IFS, which either institutionalize, partially institutionalize, or do not institutionalize IFS. Each of these pathways has implications for IFS, and the manuscript details the effects on IFS practices, and the impacts for people and landscapes.

Conclusions
To better support IFS, we must look beyond the institutionalization of IFS within the state, and nest IFS within Indigenous laws and governance. An Indigenous-led IFS approach can operate in parallel with the state, and develop innovative land-access arrangements and Tribal Parks to apply IFS to landscapes. New structures of engagement must be designed for this parallel space, grounded in the principle of free prior and informed consent (FPIC), and with explicit focus on deconstructing power differences.
Metadata recommendations for light logging and dosimetry datasets
Authors: Spitschan Manuel , Hammad Grégory , Blume Christine , Schmidt Christina , Skene Debra J. , Wulff Katharina , Santhi Nayantara , Zauner Johannes , Münch Mirjam 
Published: August 2024

Abstract
Background
Light exposure significantly impacts human health, regulating our circadian clock, sleep–wake cycle and other physiological processes. With the emergence of wearable light loggers and dosimeters, research on real-world light exposure effects is growing. There is a critical need to standardize data collection and documentation across studies.

Results
This article proposes a new metadata descriptor designed to capture crucial information within personalized light exposure datasets collected with wearable light loggers and dosimeters. The descriptor, developed collaboratively by international experts, has a modular structure for future expansion and customization. It covers four key domains: study design, participant characteristics, dataset details, and device specifications. Each domain includes specific metadata fields for comprehensive documentation. The user-friendly descriptor is available in JSON format. A web interface simplifies generating compliant JSON files for broad accessibility. Version control allows for future improvements.

Conclusions
Our metadata descriptor empowers researchers to enhance the quality and value of their light dosimetry datasets by making them FAIR (findable, accessible, interoperable and reusable). Ultimately, its adoption will advance our understanding of how light exposure affects human physiology and behaviour in real-world settings.
Is bipolar mixed depression associated with a good response to psychotropic augmentation?
Authors: Rihmer Z. 
Published: August 2024

Abstract
Is bipolar mixed depression associated with a good response to psychotropic augmentation? Zoltán Rihmer Department of Psychiatry and Psychotherapy, Semmelweis University, Budapest and at the National Institute of Mental Helath, Neurology and Neurosurgery, Budapest, Hungary.IntroductionSuboptimal response to antidepressant pharmacotherapy (nonresponse or partial response but no remisson) is the most challenging issue in the treatment of depressive disorders. Open and controlled clinical studies show that augmentation of the given antidepressant with lithium, atypical antipsychotics, antiepileptics and thyroid hormones are effective in 30-40% in such cases.Objectives
To explore the possiblity wether bipolar mixed depression is the ideal subject of good response to psychotroic augmentation.MethodLiterature review.ResultsStudies consistently indicate that in contrast to unipolar MDE (=MDD) the rate of antidepressant-resistant depression is higher not only in bipolar I and II depression but also in MDE with subthreshold bipolarity (bipolar mixed depression). However, lithium, atypical antipsychotic and antiepileptic (but not thyroid) augmentation works much better in bipolar depression and in unipolar MDE with subthreshold bipolarity (mixed depression) tjan in unipolar MDE without subthreshold bipolar features. In addition to this, almost all clinical predictors of good response to lithium/atypical antipsychotics/antiepileptics are classical bipolar markers (familial bipolarity, eraly onset, intradepressive hypomanic symptoms, agitation, cyclothymic tempermanent, shorter episodes, more than three depressive episodes, and suicidality).ConclusionConsidering that lithium, atyipcal antipsychotics and antiepileptics, but not thyroid stimulating drugs have more and less antimanic effect, these results suggst that tretating intradecpressive hypomanic symptoms in bipolar mixed depression is a new (if not the only) explanation among the several previously proposed mechanisms of action of successful psychotropic augmentation of antidepressants in patients with MDE.Disclosure of InterestNone Declared
Prevalence of Low Self-Esteem Among Patients Treated in the Craniofacial Surgery Department of an international Reference Hospital
Authors: Pereira Bernd G. , Dall Agnol Bouvier V. , Brusa da Costa Linn T. , Cho de Almeida I. , de Oliveira de Marchi B. , Guinter Muccillo L. , Menezes Chaves Barcellos C. G. , Paz Portinho C. , Martins Collares M. V. , Ribas Leite R. 
Published: August 2024

IntroductionCraniofacial surgery is a specialized field that addresses congenital and acquired deformities of the head and face. While the physical outcomes of craniofacial surgery are well-documented, less attention has been given to the psychological well-being of adult patients. This abstract aims to explore self-esteem issues among adult patients treated at the Craniofacial Surgery Sector of HCPA (Hospital de Clínicas de Porto Alegre), where a substantial proportion of adult patients have reported self-esteem problems.Objectives1.To assess the prevalence of self-esteem issues among adult patients (≥18 years old) attending the HCPA Craniofacial Surgery Sector.2.To examine potential contributing factors to self-esteem problems in this specific patient population.3.To evaluate the impact of self-esteem on the mental health and psychosocial functioning of adult craniofacial surgery patients.4.To propose recommendations for psychosocial support and intervention strategies tailored to the needs of adult patients in this context.MethodsThis cross-sectional study involved 132 adult patients who had undergone or were scheduled for craniofacial surgery at HCPA. Participants reported self-esteem issues in their talk with the hospital’s physicians, and their medical records were reviewed to collect demographic and clinical data. Additionally, participants provided information about their mental health status and psychosocial functioning.ResultsAmong the 39 adult patients included in the study, 37 (94.9%) reported experiencing self-esteem issues, such as lack of confidence or feeling unattractive. The most commonly reported contributing factors were visible facial differences, social interactions, and prior surgical experiences. Patients with lower self-esteem had a higher likelihood of reporting symptoms of depression and anxiety and reported lower overall psychosocial functioning compared to those with higher self-esteem.ConclusionsThis reveals a strikingly high prevalence of self-esteem issues among adult patients attending the Craniofacial Surgery Sector at HCPA. These findings underscore the importance of recognizing and addressing the psychological well-being of adult craniofacial surgery patients. Comprehensive psychosocial support, including counseling, peer support, and interventions to enhance self-esteem, should be integrated into the care of these patients. By addressing self-esteem concerns, healthcare providers can improve the mental health and overall quality of life of adult craniofacial surgery patients.Disclosure of InterestNone Declared
Hepatic encephalopathy in cirrhosis and alcohol dependence: complex clinical challenges and multidisciplinary management
Authors: Alario-Ruiz C. , Arribas-Simon B. , Martinez.Gimeno P. , Calvo-Valcarcel M. , Martin-Santiago O. 
Published: August 2024

IntroductionLiver cirrhosis, a chronic liver disease, can be closely linked to chronic alcohol abuse, posing a significant medical challenge. Hepatic encephalopathy (HE), a neuropsychiatric condition resulting from liver dysfunction, commonly occurs in cirrhotic patients due to the accumulation of neurotoxic substances like ammonia and manganese in the body. Managing cirrhosis and alcohol addiction is crucial to enhancing the quality of life for these patients, as HE can manifest in various ways and with varying degrees of severity.ObjectivesTo emphasize the importance of recognizing and treating hepatic encephalopathy as a potential complication of liver cirrhosis and sedatives during alcohol withdrawal.MethodsWe compiled clinical data, medical history, neuroimaging tests, and therapeutic interventions applied.ResultsA 55-year-old man with a complex medical history, including Child-Pugh B liver cirrhosis, portal hypertension, hypertension, diabetes mellitus, and chronic alcohol abuse with numerous prior hospitalizations for acute pancreatitis and severe head trauma related to alcohol consumption, presented to the emergency department with symptoms of alcohol withdrawal and suicidal thoughts, leading to lorazepam administration and a recommendation for admission to a specialized Therapeutic Community. After 72 hours, he developed hepatic encephalopathy with symptoms such as confusion, sleep disturbance, sweet-smelling breath, abnormal hand movements, conjunctival icterus, and urinary difficulties.An EEG revealed a globally attenuated and disorganized bioelectrical activity with triphasic waves. The magnetic resonance imaging showed signs of hepato-cerebral degeneration, including T1-weighted hyperintensity in the lentiform and mesencephalic nuclei due to manganese deposition. Treatment was adjusted to reduce sedative use, and therapy with Rifaximin and Lactulose was initiated to control blood ammonia levels. After a week, the patient exhibited significant neurological improvement, underscoring the importance of appropriate management in patients with hepatic encephalopathy related to liver cirrhosis and chronic alcohol abuse.ConclusionsThis case underscores the complexity of HE in patients with liver cirrhosis and alcohol dependence. HE can present in various ways, from subtle symptoms to severe episodes of confusion and coma. Findings on EEG, such as triphasic waves, are characteristic of HE and reflect brain dysfunction. Furthermore, manganese accumulation in the brain, as evidenced by magnetic resonance imaging, may contribute to neurological symptoms in cirrhotic patients. In this context, the early recognition and multidisciplinary treatment are emphasized to improve the quality of life and prevent the progression of this neuropsychiatric complication. EEG and magnetic resonance imaging findings play an essential role in the evaluation of these patients.Disclosure of InterestNone Declared