bluuebunny/crossref_metadata_2025_split huggingface dataset:
An internet-based program to enhance motivation to change in females with symptoms of an eating disorder: a randomized controlled trial
Authors: Hötzel K. , von Brachel R. , Schmidt U. , Rieger E. , Kosfelder J. , Hechler T. , Schulte D. , Vocks S. 
Published: October 2013

BackgroundPrevious research has demonstrated an association between low motivation to change and an unfavorable treatment outcome in patients with an eating disorder. Consequently, various studies have examined the effects of motivational enhancement therapy (MET) on motivation to change and treatment outcome in eating disorders. In each of these studies, MET was administered in a face-to-face setting. However, because of its anonymity and ease of access, the internet provides several advantages as the format for such an intervention. Therefore, the current study investigated the effects of an internet-based program (‘ESS-KIMO’) to enhance motivation to change in eating disorders.MethodIn total, 212 females were accepted for participation and assigned randomly to the intervention condition (n = 103) or waiting-list control condition (n = 109). The intervention consisted of six online MET sessions. Before and after the intervention or waiting period respectively, participants completed the Eating Disorder Examination Questionnaire (EDE-Q), the Stages of Change Questionnaire for Eating Disorders (SOCQ-ED), the Pros and Cons of Eating Disorders Scale (P-CED), the Self-Efficacy Scale (SES), and the Rosenberg Self-Esteem Scale (RSES). A total of 125 participants completed the assessment post-treatment. Completer analyses and intent-to-treat analyses were performed.ResultsSignificant time × group interactions were found, indicating a stronger increase in motivational aspects and self-esteem, in addition to a stronger symptom reduction on some measures from pre- to post-treatment in the intervention group compared to the control group.ConclusionsInternet-based approaches can be considered as useful for enhancing motivation to change in eating disorders and for yielding initial symptomatic improvement.
Positive and negative meanings are simultaneously ascribed to colorectal cancer: Relationship to quality of life and psychosocial adjustment
Authors: Camacho Aldo Aguirre , Garland Sheila N. , Martopullo Celestina , Pelletier Guy 
Published: October 2013

AbstractObjective:Experiencing cancer can give rise to existential concerns causing great distress, and consequently drive individuals to make sense of what cancer may mean to their lives. To date, meaning-based research in the context of cancer has largely focused on one possible outcome of this process, the emergence of positive meanings (e.g. post-traumatic growth). However, negative meanings may also be ascribed to cancer, simultaneously with positive meanings. This study focused on the nature of the co-existence of positive and negative meanings in a sample of individuals diagnosed with colorectal cancer to find out whether negative meaning had an impact on quality of life and psychosocial adjustment above and beyond positive meaning.Methods:Participants were given questionnaires measuring meaning-made, quality of life, and psychological distress. Semi structured interviews were conducted with a subgroup from the original sample.Results:Hierarchical multiple regression analyses revealed that negative meaning-made (i.e. helplessness) was a significant predictor of poor quality of life and increased levels of depression/anxiety above and beyond positive meaning-made (i.e. life meaningfulness, acceptance, and perceived benefits). Correlational analyses and interview data revealed that negative meaning-made was mainly associated with physical and functional disability, while positive meaning-made was mostly related to emotional and psychological well-being.Significance of results:Meanings of varying valence may simultaneously be ascribed to cancer as it impacts different life dimensions, and they may independently influence quality of life and psychosocial adjustment. The presence of positive meaning was not enough to prevent the detrimental effects of negative meaning on psychosocial adjustment and quality of life among individuals taking part in this study. Future attention to negative meaning is warranted, as it may be at least as important as positive meaning in predicting psychosocial adjustment and quality of life following a cancer diagnosis.
Use of an electronic patient-reported outcome measurement system to improve distress management in oncology
Authors: Smith Sophia K. , Rowe Krista , Abernethy Amy P. 
Published: October 2013

AbstractObjective:Management of patient distress is a critical task in cancer nursing and cancer practice. Here we describe two examples of how an electronic patient-reported outcome (ePRO) measurement system implemented into routine oncology care can practically aid clinical and research tasks related to distress management.Methods:Tablet personal computers were used to routinely complete a standardized ePRO review of systems surveys at point of care during every encounter in the Duke Oncology outpatient clinics. Two cases of use implementation are explored: (1) triaging distressed patients for optimal care, and (2) psychosocial program evaluation research.Results:Between 2009 and 2011, the ePRO system was used to collect information during 17,338 Duke Oncology patient encounters. The system was used to monitor patients for psychosocial distress employing an electronic clinical decision support algorithm, with 1,952 (11.3%) referrals generated for supportive services. The system was utilized to examine the efficacy of a psychosocial care intervention documenting statistically significant improvements in distress, despair, fatigue, and quality of life (QOL) in 50 breast cancer patients.Significance of results:ePRO solutions can guide best practice management of cancer patient distress. Nurses play a key role in implementation and utilization.
Design and analysis of a high-power radial multi-way combiner
Authors: Jain Akhilesh , Gupta Alok K. , Sharma Deepak Kumar , Hannurkar Pundlik Rama , Pathak Surya Kant 
Published: October 2013

In this paper, the design analysis of a multi-way and high-power radial combiner is presented. This combiner incorporates a rigid stripline-type combining structure. This analysis, based on an equivalent circuit model and segmentation of the radial transmission line, provides simple design formulae. The developed methodology, after fine-tuning with the help of an electromagnetic full-wave simulator, is physically demonstrated by developing a high-power (16 kW average) and high combining-efficiency (98.9%) 16-way combiner at the center frequency of 505.8 MHz. Its efficient and repeatable performance, fabrication-friendly structure, and absence of the heat-related problem, caused by the isolation resistor, are the main features of this design.
Satisfaction with Life Scale in a Representative Sample of Spanish Adults: Validation and Normative Data
Authors: Vázquez Carmelo , Duque Almudena , Hervás Gonzalo 
Published: October 2013

AbstractThe Satisfaction with Life Scale (SWLS) is a measure widely used to assess life satisfaction. This paper aims to test its psychometric properties, factor structure, and distribution scores across age, gender, education, and employment status. For this purpose, a representative sample of the Spanish population (N = 2,964) was used. Although analyses showed no significant differences across age or gender, participants with higher education level and those who held an occupation were more satisfied with their lives. Confirmatory factor analysis revealed a unifactorial structure with significant correlations between the SWLS, and subjective happiness and social support. The internal consistency of the scale was .88. Thus, our results indicate that the Spanish version of the SWLS is a valid and reliable measure of life satisfaction within the Spanish context.
Kinetic characterization of high-activity mutants of human butyrylcholinesterase for the cocaine metabolite norcocaine
Authors: Zhan Max , Hou Shurong , Zhan Chang-Guo , Zheng Fang 
Published: October 2013

It has been known that cocaine produces its toxic and physiological effects through not only cocaine itself, but also norcocaine formed from cocaine oxidation catalysed by microsomal CYP (cytochrome P450) 3A4 in the human liver. The catalytic parameters (kcat and Km) of human BChE (butyrylcholinesterase) and its three mutants (i.e. A199S/S287G/A328W/Y332G, A199S/F227A/S287G/A328W/E441D and A199S/F227A/S287G/A328W/Y332G) for norcocaine have been characterized in the present study for the first time and compared with those for cocaine. On the basis of the obtained kinetic data, wild-type human BChE has a significantly lower catalytic activity for norcocaine (kcat=2.8 min−1, Km=15 μM and kcat/Km=1.87×105 M−1·min−1) compared with its catalytic activity for (−)-cocaine. The BChE mutants examined in the present study have considerably improved catalytic activities against both cocaine and norcocaine compared with the wild-type enzyme. Within the enzymes examined in the present study, the A199S/F227A/S287G/A328W/Y332G mutant (CocH3) is identified as the most efficient enzyme for hydrolysing both cocaine and norcocaine. CocH3 has a 1080-fold improved catalytic efficiency for norcocaine (kcat=2610 min−1, Km=13 μM and kcat/Km=2.01×108 M−1·min−1) and a 2020-fold improved catalytic efficiency for cocaine. It has been demonstrated that CocH3 as an exogenous enzyme can rapidly metabolize norcocaine, in addition to cocaine, in rats. Further kinetic modelling has suggested that CocH3 with an identical concentration with that of the endogenous BChE in human plasma can effectively eliminate both cocaine and norcocaine in a simplified kinetic model of cocaine abuse.
Nasal and Oral Inspiration During Natural Speech Breathing
Authors: Lester Rosemary A. , Hoit Jeannette D. 
Published: October 2013

Purpose
The purpose of this study was to determine the typical pattern for inspiration during speech breathing in healthy adults, as well as the factors that might influence it.

Method
Ten healthy adults, 18–45 years of age, performed a variety of speaking tasks while nasal ram pressure, audio, and video recordings were obtained. Inspirations were categorized as nasal-only, oral-only, simultaneous nasal and oral, or alternating nasal and oral inspiration. The method was validated using nasal airflow, oral airflow, audio, and video recordings for 2 participants.

Results
The predominant pattern was simultaneous nasal and oral inspirations for all speaking tasks. This pattern was not affected either by the nature of the speaking task or by the phonetic context surrounding the inspiration. The validation procedure confirmed that nearly all inspirations during counting and paragraph reading were simultaneous nasal and oral inspirations, whereas for sentence reading, the predominant pattern was alternating nasal and oral inspirations across the 3 phonetic contexts.

Conclusions
Healthy adults inspire through both the nose and mouth during natural speech breathing. This pattern of inspiration is likely beneficial in reducing pathway resistance while preserving some of the benefits of nasal breathing.
Interpretation of Verb Phrase Telicity: Sensitivity to Verb Type and Determiner Type
Authors: Ogiela Diane A. , Schmitt Cristina , Casby Michael W. 
Published: October 2013

Purpose
The authors examine how adults use linguistic information from verbs, direct objects, and particles to interpret an event description as encoding a logical endpoint to the event described (in which case, it is telic) or not (in which case, it is atelic). Current models of aspectual composition predict that quantity-sensitive verbs combined with quantized objects produce telic predicates. Behavioral results from previous experiments have not unequivocally confirmed this prediction. The study presents a more fine-grained analysis that examines the influence of partitive verbs, resultative particles, and different determiner types on listeners' evaluations of verb phrases as telic or atelic.

Method

Forty-eight English-speaking adults participated in a truth-value judgment task to determine whether they interpreted verb phrases with different types of verbs and direct objects as telic or atelic. Participants viewed short videos and responded to a
yes/no
question after each one.

Results
The presence of partitive quantity-sensitive verbs and the presence of a definite determiner versus a cardinal number in quantized direct objects had a differential impact on listeners' interpretations of sentences as telic.

Conclusion
The results indicate that actual behavioral interpretations of telicity are meaningfully influenced by the presence of partitive verbs, resultative particles, and different types of determiners.
SecStAnT: secondary structure analysis tool for data selection, statistics and models building
Authors: Maccari Giuseppe , Spampinato Giulia L.B. , Tozzini Valentina 
Published: October 2013

AbstractMotivation: Atomistic or coarse grained (CG) potentials derived from statistical distributions of internal variables have recently become popular due to the need of simplified interactions for reaching larger scales in simulations or more efficient conformational space sampling. However, the process of parameterization of accurate and predictive statistics-based force fields requires a huge amount of work and is prone to the introduction of bias and errors.Results: This article introduces SecStAnT, a software for the creation and analysis of protein structural datasets with user-defined primary/secondary structure composition, with a particular focus on the CG representation. In addition, the possibility of managing different resolutions and the primary/secondary structure selectivity allow addressing the mapping-backmapping of atomistic to CG representation and study the secondary to primary structure relations. Sample datasets and distributions are reported, including interpretation of structural features.Availability and implementation: SecStAnT is available free of charge at secstant.sourceforge.net/. Source code is freely available on request, implemented in Java and supported on Linux, MS Windows and OSX.Contact: giuseppe.maccari@iit.itSupplementary information: Supplementary data are available at Bioinformatics online.
ORMAN: Optimal resolution of ambiguous RNA-Seq multimappings in the presence of novel isoforms
Authors: Dao Phuong , Numanagić Ibrahim , Lin Yen-Yi , Hach Faraz , Karakoc Emre , Donmez Nilgun , Collins Colin , Eichler Evan E. , Sahinalp S. Cenk 
Published: October 2013

Abstract
Motivation: RNA-Seq technology is promising to uncover many novel alternative splicing events, gene fusions and other variations in RNA transcripts. For an accurate detection and quantification of transcripts, it is important to resolve the mapping ambiguity for those RNA-Seq reads that can be mapped to multiple loci: &gt;17% of the reads from mouse RNA-Seq data and 50% of the reads from some plant RNA-Seq data have multiple mapping loci.
In this study, we show how to resolve the mapping ambiguity in the presence of novel transcriptomic events such as exon skipping and novel indels towards accurate downstream analysis. We introduce ORMAN (Optimal Resolution of Multimapping Ambiguity of RNA-Seq Reads), which aims to compute the minimum number of potential transcript products for each gene and to assign each multimapping read to one of these transcripts based on the estimated distribution of the region covering the read. ORMAN achieves this objective through a combinatorial optimization formulation, which is solved through well-known approximation algorithms, integer linear programs and heuristics.
Results: On a simulated RNA-Seq dataset including a random subset of transcripts from the UCSC database, the performance of several state-of-the-art methods for identifying and quantifying novel transcripts, such as Cufflinks, IsoLasso and CLIIQ, is significantly improved through the use of ORMAN. Furthermore, in an experiment using real RNA-Seq reads, we show that ORMAN is able to resolve multimapping to produce coverage values that are similar to the original distribution, even in genes with highly non-uniform coverage.
Availability: ORMAN is available at http://orman.sf.net
Contact: cenk@cs.sfu.ca
Supplementary information: Supplementary data are available at Bioinformatics online.
Bullying and ADHD: Which Came First and Does it Matter?
Authors: Keder Robert , Sege Robert , Raffalli Peter C. , Augustyn Marilyn 
Published: October 2013

CASE: Aiden, a 13-year-old boy in the sixth grade who is relatively new to your practice, is seen for follow-up after his routine physical last month when you noted concerns for possible attention-deficit hyperactivity disorder (ADHD) and gave the family Vanderbilt Scales to complete. Aiden has a family history of ADHD, specific learning disabilities, and mood disorder.
His mother reports that she is concerned about how Aiden is doing at school; his teachers are complaining that he is not doing his work, and she is worried that he may be kept back in school. Aiden first began having trouble in the third grade. He was retained in the fourth grade for academic and behavioral reasons. Now his mother has been receiving calls about him not paying attention, distracting others, and staring at his paper. At home, he does not want to do homework and gets very frustrated. In fifth grade, he had a psychoeducational evaluation and was found not eligible for services. His achievement testing showed average scores in reading, math, and writing. Cognitive testing demonstrated average scores for verbal and nonverbal abilities and memory but was significantly below average for processing speed. Aiden continues to have problems now in into the sixth grade.
You speak with Aiden in the office and ask him about school. He says, “It's bad. I'm failing.” He believes his major problems at school are that he is not doing his homework, he easily becomes frustrated, and he argues with the teachers. He has supportive relationships with his family and friends at school. He gets along well with some of his teachers, noting that he loves his science teacher even though she is tough and “gives hard homework.” He describes his history teacher as “annoying.” When you ask what he means he states this teacher “Can be not nice and says mean things. She picks on me a lot.” His description is consistent with the use of shaming as a behavior he experiences at school.
You review the completed parent and teacher Vanderbilt forms; both are consistent and concerning for combined type ADHD. You discuss the diagnosis of ADHD with his mother and both agree to revisit pharmacotherapy in September when the school year resumes. You give her resources on ADHD and classroom accommodations and discuss requesting a 504 plan at school. You also discuss behavioral therapy to better address his self-regulation skills.
A week later, you receive a telephone call from Aiden's mother. “Aiden got home today and he is more upset than I have ever seen him! His teacher told him in front of the class that he would probably stay back a year and now he is saying there is no point in going to school.” She is not aware if retention has been recommended for Aiden.
What would you say to Aiden's mother? What would you do next?
Rice WRKY13 Regulates Cross Talk between Abiotic and Biotic Stress Signaling Pathways by Selective Binding to Different cis-Elements
Authors: Xiao Jun , Cheng Hongtao , Li Xianghua , Xiao Jinghua , Xu Caiguo , Wang Shiping 
Published: October 2013

AbstractPlants use a complex signal transduction network to regulate their adaptation to the ever-changing environment. Rice (Oryza sativa) WRKY13 plays a vital role in the cross talk between abiotic and biotic stress signaling pathways by suppressing abiotic stress resistance and activating disease resistance. However, it is not clear how WRKY13 directly regulates this cross talk. Here, we show that WRKY13 is a transcriptional repressor. During the rice responses to drought stress and bacterial infection, WRKY13 selectively bound to certain site- and sequence-specific cis-elements on the promoters of SNAC1 (for STRESS RESPONSIVE NO APICAL MERISTEM, ARABIDOPSIS TRANSCRIPTION ACTIVATION FACTOR1/2, CUP-SHAPED COTYLEDON), the overexpression of which increases drought resistance, and WRKY45-1, the knockout of which increases both bacterial disease and drought resistance. WRKY13 also bound to two cis-elements of its native promoter to autoregulate the balance of its gene expression in different physiological activities. WRKY13 was induced in leaf vascular tissue, where bacteria proliferate, during infection, and in guard cells, where the transcriptional factor SNAC1 enhances drought resistance, during both bacterial infection and drought stress. These results suggest that WRKY13 regulates the antagonistic cross talk between drought and disease resistance pathways by directly suppressing SNAC1 and WRKY45-1 and autoregulating its own expression via site- and sequence-specific cis-elements on the promoters of these genes in vascular tissue where bacteria proliferate and guard cells where the transcriptional factor SNAC1 mediates drought resistance by promoting stomatal closure.
Pustulotic arthro‐osteitis associated with palmoplantar pustulosis
Authors: Yamamoto Toshiyuki 
Published: October 2013

AbstractPalmoplantar pustulosis (PPP) is a chronic inflammatory disorder characterized by sterile pustules predominantly involving the palms and soles of middle‐aged women. PPP frequently develops or exacerbates following focal infections, such as tonsillitis, odontogenic infection and sinusitis, either with or without arthralgia and/or extra‐palmoplantar lesions. Pustulotic arthro‐osteitis (PAO) is a joint comorbidity of PPP, most often affecting the anterior chest wall. PAO is sometimes regarded as the same entity as synovitis, acne, pustulosis, hyperostosis and osteitis (SAPHO) syndrome, and may be a subtype or incomplete type of SAPHO syndrome; however, there are several differences. In Japanese patients, PPP with PAO is frequently seen, whereas SAPHO syndrome in the true meaning is rare. A difference of incidence depending on race suggests that different genetic backgrounds may be responsible for susceptibility to these disorders. Bacterial infection, especially Propionibacterium acnes, is suggested to play an important role in the pathogenesis of SAPHO syndrome. P. acnes is responsible for acne, however, bacterium is unassociated with PPP skin lesions which are characterized by sterile pustules. On the other hand, PAO is frequently triggered by focal infection, and treatment of focal infection results in dramatic effects on the release of joint pain. This paper reviews current insights into the clinicopathophysiology of PAO, and discusses its possible mechanisms in comparison with SAPHO syndrome.