bluuebunny/crossref_metadata_2025_split huggingface dataset:
Elevated Cancer-Specific Mortality Among HIV-Infected Patients in the United States
Authors: Coghill Anna E. , Shiels Meredith S. , Suneja Gita , Engels Eric A. 
Published: June 2015

PurposeDespite advances in the treatment of HIV, HIV-infected people remain at increased risk for many cancers, and the number of non–AIDS-defining cancers is increasing with the aging of the HIV-infected population. No prior study has comprehensively evaluated the effect of HIV on cancer-specific mortality.Patients and MethodsWe identified cases of 14 common cancers occurring from 1996 to 2010 in six US states participating in a linkage of cancer and HIV/AIDS registries. We used Cox regression to examine the association between patient HIV status and death resulting from the presenting cancer (ascertained from death certificates), adjusting for age, sex, race/ethnicity, year of cancer diagnosis, and cancer stage. We included 1,816,461 patients with cancer, 6,459 (0.36%) of whom were HIV infected.ResultsCancer-specific mortality was significantly elevated in HIV-infected compared with HIV-uninfected patients for many cancers: colorectum (adjusted hazard ratio [HR], 1.49; 95% CI, 1.21 to 1.84), pancreas (HR, 1.71; 95% CI, 1.35 to 2.18), larynx (HR, 1.62; 95% CI, 1.06 to 2.47), lung (HR, 1.28; 95% CI, 1.17 to 1.39), melanoma (HR, 1.72; 95% CI, 1.09 to 2.70), breast (HR, 2.61; 95% CI, 2.06 to 3.31), and prostate (HR, 1.57; 95% CI, 1.02 to 2.41). HIV was not associated with increased cancer-specific mortality for anal cancer, Hodgkin lymphoma, or diffuse large B-cell lymphoma. After further adjustment for cancer treatment, HIV remained associated with elevated cancer-specific mortality for common non–AIDS-defining cancers: colorectum (HR, 1.40; 95% CI, 1.09 to 1.80), lung (HR, 1.28; 95% CI, 1.14 to 1.44), melanoma (HR, 1.93; 95% CI, 1.14 to 3.27), and breast (HR, 2.64; 95% CI, 1.86 to 3.73).ConclusionHIV-infected patients with cancer experienced higher cancer-specific mortality than HIV-uninfected patients, independent of cancer stage or receipt of cancer treatment. The elevation in cancer-specific mortality among HIV-infected patients may be attributable to unmeasured stage or treatment differences as well as a direct relationship between immunosuppression and tumor progression.
Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108
Authors: Barr Paul M. , Li Hongli , Spier Catherine , Mahadevan Daruka , LeBlanc Michael , Ul Haq Mansoor , Huber Bryan D. , Flowers Christopher R. , Wagner-Johnston Nina D. , Horwitz Steven M. , Fisher Richard I. , Cheson Bruce D. , Smith Sonali M. , Kahl Brad S. , Bartlett Nancy L. , Friedberg Jonathan W. 
Published: June 2015

Purpose Aurora A kinase (AAK) is upregulated in highly proliferative lymphomas, suggesting its potential as a therapeutic target. Alisertib is a novel oral AAK inhibitor without adverse safety signals in early-phase studies that demonstrated preliminary activity in T-cell lymphoma. This phase II study was conducted to further investigate the efficacy of alisertib in relapsed or refractory peripheral T-cell non-Hodgkin lymphoma (PTCL). Patients and Methods Eligible patients with histologically confirmed relapsed/refractory PTCL or transformed Mycosis fungoides (tMF) received alisertib 50 mg twice a day for 7 days on 21-day cycles. Results Of 37 eligible patients, the histologic subtypes enrolled included PTCL not otherwise specified (n = 13), angioimmunoblastic T-cell lymphoma (n = 9), tMF (n = 7), adult T-cell lymphoma/leukemia (n = 4), anaplastic large-cell lymphoma (n = 2), and extranodal natural killer/T-cell lymphoma (n = 2). Grade 3 and 4 adverse events in ≥ 5% of patients included neutropenia (32%), anemia (30%), thrombocytopenia (24%), febrile neutropenia (14%), mucositis (11%), and rash (5%). Treatment was discontinued most commonly for disease progression. Among the PTCL subtypes, the overall response rate was 30%, whereas no responses were observed in tMF. Aurora B kinase was more commonly overexpressed than AAK in tumor specimens. Analysis of AAK, Aurora B kinase, MYC, BCL-2, phosphatidylinositol 3-kinase γ, and Notch1 expression revealed no association with response. Conclusion Alisertib has antitumor activity in PTCL, including heavily pretreated patients. These promising results are being further investigated in an ongoing international, randomized phase III trial comparing alisertib with investigator's choice in PTCL.
Long-Term Follow-Up of the E1199 Phase III Trial Evaluating the Role of Taxane and Schedule in Operable Breast Cancer
Authors: Sparano Joseph A. , Zhao Fengmin , Martino Silvana , Ligibel Jennifer A. , Perez Edith A. , Saphner Tom , Wolff Antonio C. , Sledge George W. , Wood William C. , Davidson Nancy E. 
Published: June 2015

Purpose To determine long-term outcomes in a clinical trial evaluating the role of taxane type and schedule in operable breast cancer and evaluate the impact of obesity and black race on outcome. Patients and Methods A total of 4,954 eligible women with stage II to III breast cancer treated with four cycles of doxorubicin plus cyclophosphamide were randomly assigned to receive paclitaxel or docetaxel every 3 weeks for four doses or weekly for 12 doses using a 2 × 2 factorial design. The primary end point was disease-free survival (DFS). Results are expressed as hazard ratios (HRs) from Cox proportional hazards models. All P values are two sided. Results When compared with the standard every-3-week paclitaxel arm, after a median follow-up of 12.1 years, DFS significantly improved and overall survival (OS) marginally improved only for the weekly paclitaxel (HR, 0.84; P = .011 and HR, 0.87; P = .09, respectively) and every-3-week docetaxel arms (HR, 0.79; P = .001 and HR, 0.86; P = .054, respectively). Weekly paclitaxel improved DFS and OS (HR, 0.69; P = .010 and HR, 0.69; P = .019, respectively) in triple-negative breast cancer. For hormone receptor–positive, human epidermal growth factor receptor 2–nonoverexpressing disease, no experimental arm improved OS, and black race and obesity were associated with increased risk of breast cancer recurrence and death. Conclusion Improved outcomes initially observed for weekly paclitaxel were qualitatively similar but quantitatively less pronounced with longer follow-up, although exploratory analysis suggested substantial benefit in triple-negative disease. Further research is required to understand why obesity and race influence clinical outcome in hormone receptor–positive disease.
BEST: A Randomized Phase II Study of Vascular Endothelial Growth Factor, RAF Kinase, and Mammalian Target of Rapamycin Combination Targeted Therapy With Bevacizumab, Sorafenib, and Temsirolimus in Advanced Renal Cell Carcinoma—A Trial of the ECOG–ACRIN Cancer Research Group (E2804)
Authors: Flaherty Keith T. , Manola Judith B. , Pins Michael , McDermott David F. , Atkins Michael B. , Dutcher Janice J. , George Daniel J. , Margolin Kim A. , DiPaola Robert S. 
Published: June 2015

Purpose On the basis of evidence that resistance to vascular endothelial growth factor (VEGF) receptor inhibition is caused by hypoxia-driven residual VEGF and other proangiogenic factors, combinations of agents from these classes were hypothesized to improve treatment outcomes relative to single-agent VEGF pathway blockade. Patients and Methods A total of 361 patients with metastatic clear cell renal cell carcinoma were randomly assigned equally to arm A (bevacizumab monotherapy 10 mg/kg intravenously [IV] every 2 weeks), B (bevacizumab 10 mg/kg IV every 2 weeks and temsirolimus 25 mg IV every week), C (bevacizumab 5 mg/kg IV every 2 weeks and sorafenib 200 mg orally twice daily on days 1 to 5, 8 to 12, 15 to 19, and 22 to 26), or D (sorafenib 200 mg twice daily and temsirolimus 25 mg IV weekly). Progression-free survival was the primary end point. Results Among 331 eligible treated patients, median PFS was 7.5 months for bevacizumab alone (90% CI, 5.8 to 10.8 months), 7.6 months for bevacizumab plus temsirolimus (90% CI, 6.7 to 9.2 months), 9.2 months for bevacizumab plus sorafenib (90% CI, 7.5 to 11.4 months), and 7.4 months for sorafenib plus temsirolimus (90% CI, 5.6 to 7.9 months). Hazard ratios from stratified Cox proportional hazards models were 1.01, 0.89, and 1.07 (with respective P values of .95, .49, and .68) for the three combinations, respectively, compared with bevacizumab alone. Adverse events did not differ significantly among treatment arms. Conclusion The activity of sorafenib, temsirolimus, and bevacizumab administered in doublet combinations did not significantly improve median progression-free survival in comparison with bevacizumab monotherapy.
Antiquity in Social Media: The Case of the ‘Filmweb’ Portal and Its Users
Authors: Dominas Konrad 
Published: June 2015

Antiquity in Social Media: The Case of the ‘Filmweb’ Portal and Its Users
The paper analyses the character of classical receptions and the proposed methodology of its analysys within the context of the new media. An example of a popular Polish website Filmweb, devoted to cinema, is used to present the case postulating new interdisciplinary methodology, necessary for the research on the receptions of antiquity in the new media.
Dionysos, Orpheus and Argead Macedonia
Authors: Fulińska Agnieszka 
Published: June 2015

Dionysos, Orpheus and Argead Macedonia. Overwiev and Perspectives
The cult of Dionysos in ancient Macedonia and its possible relation to the Orphic beliefs is one of the most interesting aspects of the Macedonian culture, one, however, accessible to us only via very fragmentary and indirect evidence, partly textual, partly archaeological. The paper summarizes the most important aspects according to the status quaestionis and proposes some interpretations of the problem.
Artificum scaenicorum studium amoremque inhonestum probrosumque esse
Authors: Loska Elżbieta 
Published: June 2015

Artificum scaenicorum studium amoremque inhonestum probrosumque esse. The Actor and their Audience in the Roman Theatre
The paper analyses the role and position of actors in ancient Rome, from the times of the Republic to the principate. Main emphasis is put on the legal understanding of problems such as the special order of seating in Roman theatres and the privileges of senators and ordo equester, social position of actors and the question of the citizens’ participation (willing or not) in the performances.
The Hidden Author of the Corpus Dionysacium - Authenticity, Rejection, and Apohasis in Historical Context
Authors: Wdowiak Magdalena 
Published: June 2015

Hidden Author of the Corpus Dionysacium - Authenticity, Rejection, and Apohasis in Historical Context
The following paper aims to show that explanation of Pseudo‑Dionysius’ identity has importance to the interpretation of the Corpus Dionysiacum philosophy. I investigate the turn in the Dionysian issue that took place in the history of research on the author’s true identity: from plain recognition of Dionysius first‑century authorship, through its negation, back to acknowledgement of his relation to the times of Apostles as significant. The first part of the paper includes introduction into chosen aspects of the history of the research into the Corpus Dionysiacum author’s identity. The closing part refers to the conception of the contemporary scholars Ch. M. Stang and W. Riordan, who have tried to understand the meaning of the unknown author’s pseudonym as important to interpretation of all his writings.The scholars’ assumption is to reveal that the author and his work arecomplementary elements, and that separation causes some loss.
Pyloric Leiomyoma: Behavioural Aspects in a Shelter Dog
Authors: Benedetti Riccardo , Barabucci Mirko , Pigliapoco Alessandra , Cannas Simona , Palestrini Clara 
Published: June 2015

Abstract
The present report describes a case of pyloric wall leiomyoma in a shelter dog with a history of vomiting, pica, licking and chewing the walls of the kennel. The clinical, radiological, ultrasound, hematological and blood chemistry examinations showed no abnormalities. A compulsive oral disorder was diagnosed and treatment with behaviour therapy instigated. The compulsive oral behaviours stopped following behaviour therapy, however, the vomiting persisted, suggesting the need to proceed with further diagnostic exams. The ultrasound examination, repeated after 6 months, had revealed the presence of a hypoechoic mass (3.52 cm) in the pyloric-antrum obstructing the gastric outflow. Following gastric dilatation the mass was surgically excised. Histological examination revealed a pyloric leiomyoma. In clinical practice this case highlights the importance of gastrointestinal diseases in the development of behaviour changes related to pica.
Why does critical literacy hit a snag in the Iranian EFL setting?
Authors: Rahimi Ali , Askari Bigdeli Rouhollah 
Published: June 2015

This study sought to elucidate the challenges of critical literacy practice in an Iranian context. The objectives were twofold: (a) to find out what challenges teachers and students face in the practice of critical literacy and (b) to explore the state of critical literacy in language education. To this end, a sample of 12 English teachers and 120 students majoring in TEFL took part in the study. Data collection procedure was based on students’ reflective notes, semi-structured interviews, and classroom observations. The analysis of the interviews revealed that factors including a) lack of the teachers' familiarity with the concept and tenets of critical literacy, b) students' poor English proficiency, c) lack of attention to critical literacy in curriculum and d) political issues were the major challenges. Classroom observations and students' reflective notes showed that teachers did not encourage students to become involved in ideologies imbedded in the texts.
Identificación de relaciones entre los nodos de una red social
Authors: Barón Mónica Andrea Niño , Ordóñez Salinas Sonia 
Published: June 2015

<p>El presente artículo realiza una revisión del tema, representación y clasificación de de relaciones de pertenencia entre los nodos de una red social. Para ello, se abordan aspectos sobre Procesamiento de Lenguaje Natural, Minería de Texto, Recuperación de Información<br />y Entidades Nombradas. Se hace una descripción de cada una de ellas y se referencian y discuten trabajos académicos destacados que se han desarrollado en dicho tema.</p>
Generador de Grafos Multi-relacionales a partir de redes sociales
Authors: Almagro Blanco Pedro , Ordoñez Salinas Sonia 
Published: June 2015

<p>La herramienta presentada en este artículo, <em>CorpuRed</em>, permite obtener datos de plataformas sociales en línea para ser utilizados en proyectos de investigación que requieran de información sobre el comportamiento social en Internet. La forma de obtener dichos datos depende ligeramente de cada plataforma (se muestra el caso particular de Facebook), y posteriormente son almacenados en una base de datos en grafo que será accesible a través de una API bajo una licencia académica. </p>
Realce de candidatos a nódulo pulmonar en radiografías de tórax por medio de filtros de convergencia
Authors: Duarte Pacheco Sergio Alejandro , Aguillón Pérez Julián Mauricio , Herrera García Rodrigo Javier 
Published: June 2015

Este artículo presenta el desarrollo de una herramienta de software para el realce de áreas sospechosas de nódulos pulmonares en radiografías de tórax. Los nódulos pulmonares son lesiones que se encuentran dentro de la regíon pulmonar y son los primeros indicadores de la presencia de un tumor cancerígeno en este órgano. En primera instancia, se implementa un método de segmentación automático. Luego, para el realce de los candidatos, se usan filtros de convergencia que evalúan el grado en el que converge el área circundante al píxel de interés, asumiendo que los posibles candidatos a nódulos presentan forma circular. En este trabajo se implementan cuatro filtros de convergencia: Moneda, Iris, Anillo Adaptativo y Banda Deslizante. Los filtros de moneda y de anillo adaptativo obtuvieron mejores resultados en cuanto a detección y número de candidatos por imagen. Al aplicar la técnica de resta contralateral junto con los filtros basados en características geométricas tales como área, redondez y excentricidad, se logró disminuir el número de candidatos.
Optimización multiobjetivo en la gestión de cadenas de suministro de biocombustibles. Una revisión de la literatura
Authors: Aranda Pinilla Johan Alexander , Orjuela Castro Javier Arturo 
Published: June 2015

<p>La producción de biocombustibles ha tenido un crecimiento constante durante los últimos años y se espera siga creciendo en el mediano y largo plazo. Este crecimiento ha sido impulsado principalmente por las ventajas ambientales que podrían traer en comparación con el combustible fósil, como reducción en las emisiones de gases efecto invernadero, balance energético positivo y desarrollo económico para los países productores. Sin embargo, a pesar de sus beneficios, existen preocupaciones por los impactos ambientales y sociales que pueden generar su producción y distribución. La teoría de la decisión multi-criterio se ha utilizado en los últimos años como marco para integrar los diferentes objetivos en la toma de decisiones en las cadenas de suministro de biocombustibles.</p><p>El propósito de este artículo es presentar una revisión de los conceptos y métodos principales de la optimización multi-objetivo, así como la aplicación de éstos en el diseño y planificación de cadenas de suministro de biocombustibles. El estudio muestra que el costo es el objetivo económico más frecuente, las emisiones de efecto invernadero son el objetivo ambiental más utilizado y el número de empleos creados es el criterio social más considerado, dejando de lado aspectos relevantes como la seguridad alimentaria.<strong></strong></p><p><strong> </strong></p><p> </p><p> </p>
A hybrid column generation and clustering approach to the school bus routing problem with time windows
Authors: Lopez Santana Eduyn Ramiro , Romero Carvajal Jose de Jesus 
Published: June 2015

<span>This paper attempts to solve the School Bus Routing Problem with Time Windows that consists of finding the best set of routes to pick up students distributed geographically with constraints as capacity, time windows and maximum travel time. We formulated the problem as a classic Vehicle Routing Problem with Time Windows and solved it using an approach based on a clustering algorithm and column generation method. A real world case from a school in Bogotá, Colombiais presented including 600 students to pick up in near 400 nodes located in urban and rural areas. The obtained results demonstrate a reduction as the problem’s complexity and an improvement on the performance measures of the proposed method.</span>
Evaluación de políticas de protección en el sector papicultor mediante sistemas dinámicos: caso Villapinzón (Cundinamarca)
Authors: Farfán Pinzón Milena , Peña Ardila Geimar 
Published: June 2015

<p> El sistema de producción de papa es una actividad económica de gran relevancia en zonas frías de la Región Andina (Suramérica). En Colombia, se constituye en la principal actividad agrícola de clima frío, caracterizando una producción predominantemente campesina, con escasa infraestructura tecnológica y escaso nivel de gestión agroempresarial, cuya producción exige elevados costos y cuya rentabilidad depende de precios de mercado altamente fluctuantes. En el presente artículo se utiliza el enfoque de sistemas dinámicos para modelar el contexto de dicho sistema productivo. En el documento se evalúa el impacto de las políticas de protección al sector papicultor en el municipio de Villapinzón Cundinamarca (municipio de mayor área sembrada en Colombia), desarrollando un modelo de análisis estructurado que permite medir dicho impacto sobre los indicadores de desempeño del sistema. De esta manera se comparan los escenarios actuales, propuestos por el gobierno y los propuestos con el enfoque de sistemas dinámicos, encontrando en estos últimos una opción de mejora para los agricultores del sector papicultor.</p>
Domestic hydrogen installation in Poland – technical and economic analysis
Authors: Cholewiński Maciej , Tomków Łukasz 
Published: June 2015

Abstract
The application of renewable energy sources poses the problems connected with output volatility. In order to decrease this effect the energy storage technologies can be applied, particularly fuel cells connected with hydrogen storage. In this paper the application of SOFC system for a household in Poland is proposed. Economic and technical analysis is performed. It was found that the proposed installation is profitable after 25 years of operation when compared with conventional solution - heat pumps and gas-fired boilers
Thermal analytical winding size optimization for different conductor shapes
Authors: Wojda Rafal P. 
Published: June 2015

Abstract
The aim of this paper is to derive an analytical equations for the temperature dependent optimum winding size of inductors conducting high frequency ac sinusoidal currents. Derived analytical equations are useful designing tool for research and development engineers because windings made of foil, square-wire, and solid-round-wire windings are considered. Temperature dependent Dowell’s equation for the ac-to-dc winding resistance ratio is given and approximated. Thermally dependent analytical equations for the optimum foil thickness, as well as valley thickness and diameter of the square-wire and solid-round-wire windings are derived from approximated thermally dependent ac-to-dc winding resistance ratios. Minimum winding ac resistance of the foil winding and local minimum of the winding ac resistance of the solid-round-wire winding are verified with Maxwell 3D Finite Element Method simulations
Coupled wave-equation and eddy-current model for modelling and measuring propagating stress-waves
Authors: Peussa Tommi , Belahcen Anouar 
Published: June 2015

AbstractThe coupling of the propagating stress wave with the eddy current model is presented. The applied stress produces magnetization in the sample that can be measured outside the sample by measuring the resulting magnetic flux density. The stress and flux density measurements are made on a mechanically excited steel bar. The problem is modelled with the finite element method for both the propagating wave and the eddy current. Three aspects are considered: eddy current model using magnetization from the measurements, coupled wave and eddy current models, and coupled different dimensions in the wave model. The measured stress can be reproduced from the measured flux density by modelling. The coupled models work both for stress and flux couplings as well as for the different dimensionality couplings.
Voltage induced by currents in power-line sagged conductors in nearby circuits of arbitrary configuration
Authors: Budnik Krzysztof , Machczyński Wojciech , Szymenderski Jan 
Published: June 2015

Abstract
The study presents a calculation method of the voltage induced by power-line sagged conductor in an inductively coupled overhead circuit of arbitrary configuration isolated from ground. The method bases on the solution utilizing the magnetic vector potential for modeling 3D magnetic fields produced by sagging conductors of catenary electric power lines. It is assumed that the equation of the catenary exactly describes the line sag and the influence of currents induced in the earth on the distribution of power line magnetic field is neglected. The method derived is illustrated by exemplary calculations and the results obtained are partially compared with results computed by optional approach