bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical management and perioperative morbidity of patients with primary borderline ovarian tumor (BOT)
Authors: Trillsch Fabian , Ruetzel Jan David , Herwig Uwe , Doerste Ulrike , Woelber Linn , Grimm Donata , Choschzick Matthias , Jaenicke Fritz , Mahner Sven 
Published: July 2013

Abstract

Background
Surgery is the cornerstone for clinical management of patients with borderline ovarian tumors (BOT). As these patients have an excellent overall prognosis, perioperative morbidity is the critical point for decision making when the treatment strategy is developed and the primary surgical approach is defined.

Methods
Clinical and surgical parameters of patients undergoing surgery for primary BOT at our institutions between 1993 and 2008 were analyzed with regard to perioperative morbidity depending on the surgical approach (laparotomy vs. laparoscopy).

Results
A total of 105 patients were analyzed (44 with primary laparoscopy [42%], 61 with primary laparotomy [58%]). Complete surgical staging was achieved in 33 patients at primary surgical approach (31.4%) frequently leading to formal indication of re-staging procedures. Tumor rupture was significantly more frequent during laparoscopy compared to laparotomy (29.5% vs. 13.1%, p = 0.038) but no other intraoperative complications were seen in laparoscopic surgery in contrast to 7 of 61 laparotomies (0% vs. 11.5%, p = 0.020). Postoperative complication rates were similar in both groups (19.7% vs. 18.2%, p = 0.848).

Conclusions
Irrespective of the surgical approach, surgical management of BOT has acceptable rates of perioperative complications and morbidity. Choice of initial surgical approach can therefore be made independent of complication-concerns. As the recently published large retrospective AGO ROBOT study observed similar oncologic outcome for both approaches, laparoscopy can be considered for staging of patients with BOT if this appears feasible. An algorithm for the surgical management of BOT patients has been developed.
MicroRNA Signature Obtained From the Comparison of Aggressive With Indolent Non-Hodgkin Lymphomas: Potential Prognostic Value in Mantle-Cell Lymphoma
Authors: Goswami Rashmi S. , Atenafu Eshetu G. , Xuan Yali , Waldron Levi , Reis Patricia P. , Sun Thomas , Datti Alessandro , Xu Wei , Kuruvilla John , Good David J. , Lai Raymond , Church Alanna J. , Lam Wilson S. , Baetz Tara , LeBrun David P. , Sehn Laurie H. , Farinha Pedro , Jurisica Igor , Bailey Denis J. , Gascoyne Randy D. , Crump Michael , Kamel-Reid Suzanne 
Published: July 2013

PurposeMantle-cell lymphoma (MCL) has a variable natural history but is incurable with current therapies. MicroRNAs (miRs) are useful in prognostic assessment of cancer. We determined an miR signature defining aggressiveness in B-cell non-Hodgkin lymphomas (NHL) and assessed whether this signature aids in MCL prognosis.MethodsWe assessed miR expression in a training set of 43 NHL cases. The miR signature was validated in 44 additional cases and examined on a training set of 119 MCL cases from four institutions in Canada. miRs significantly associated with overall survival were examined in an independent cohort of 114 MCL cases to determine association with patient outcome. miR expression was combined with current clinical prognostic factors to develop an enhanced prognostic model in patients with MCL.ResultsFourteen miRs were differentially expressed between aggressive and indolent NHL; 11 of 14 were validated in an independent set of NHL (excluding MCL). miR-127-3p and miR-615-3p were significantly associated with overall survival in the MCL training set. Their expression was validated in an independent MCL patient set. In comparison with Ki-67, expression of these miRs was more significantly associated with overall survival among patients with MCL. miR-127-3p was combined with Ki-67 to create a new prognostic model for MCL. A similar model was created with miR-615-3p and Mantle Cell Lymphoma International Prognostic Index scores.ConclusionEleven miRs are differentially expressed between aggressive and indolent NHL. Two novel miRs were associated with overall survival in MCL and were combined with clinical prognostic models to generate novel prognostic data for patients with MCL.
Taxane-Cisplatin-Fluorouracil As Induction Chemotherapy in Locally Advanced Head and Neck Cancers: An Individual Patient Data Meta-Analysis of the Meta-Analysis of Chemotherapy in Head and Neck Cancer Group
Authors: Blanchard Pierre , Bourhis Jean , Lacas Benjamin , Posner Marshall R. , Vermorken Jan B. , Hernandez Juan J. Cruz , Bourredjem Abderrahmane , Calais Gilles , Paccagnella Adriano , Hitt Ricardo , Pignon Jean-Pierre 
Published: July 2013

Purpose Cisplatin plus fluorouracil (PF) induction chemotherapy has been compared with taxane (docetaxel or paclitaxel), cisplatin, and fluorouracil (Tax-PF) in randomized trials in locoregionally advanced head and neck cancers (LAHNCs). The aim of this meta-analysis was to study the efficacy and toxicity of Tax-PF and PF and identify differences in outcomes in subsets of patients. Methods Five randomized trials representing 1,772 patients were identified. Updated individual patient data (IPD) were retrieved for all trials. The log-rank test, stratified by trial, was used for comparison. Interaction or trend tests were used to study the interaction between covariates and treatment. Results Median follow-up was 4.9 years. The hazard ratio (HR) of death was 0.79 (95% CI, 0.70 to 0.89; P < .001; absolute benefit at 5 years: 7.4%) in favor of Tax-PF. Heterogeneity was significant (P = .08, I2 = 51%) and related to one trial. There was no more heterogeneity after exclusion of this trial (P = .99, I2 = 0%), and HR of death was 0.72 (95% CI, 0.63 to 0.83) in favor of Tax-PF. There was no interaction between treatment effect and the following patient covariates: age, sex, performance status, tumor stage, or site. Tax-PF was associated with significant reductions of progression, locoregional failure, and distant failure compared with PF, with HRs of 0.78 (95% CI, 0.69 to 0.87; P < .001), 0.79 (95% CI, 0.66 to 0.94; P = .007), and 0.63 (95% CI, 0.45 to 0.89; P = .009) respectively. Conclusion This IPD meta-analysis shows the superiority of Tax-PF over PF as induction chemotherapy. Its precise role in the management of LAHNC remains to be determined.
A histological and functional study on hippocampal formation of normal and diabetic rats
Authors: Amin Shaimaa N , Younan Sandra M , Youssef Mira F , Rashed Laila A , Mohamady Ibrahim 
Published: July 2013

Background:The hippocampus is a key brain area for many forms of learning and memory and is particularly sensitive to changes in glucose homeostasis.Aim of the work:To investigate in experimentally induced type 1 and 2 diabetes mellitus in rat model the effect of diabetes mellitus on cognitive functions and related markers of hippocampal synaptic plasticity, and the possible impact of blocking N-methyl-D-aspartic acid (NMDA) receptors by memantine.Materials and methods:Seven rat groups were included: non-diabetic control and non-diabetic receiving memantine; type-1 diabetic groups - untreated, treated with insulin alone and treated with insulin and memantine; and type 2 diabetic groups - untreated and memantine treated. Cognitive functions were assessed by the Morris Water Maze and passive avoidance test. Biochemical analysis was done for serum glucose, serum insulin and insulin resistance. Routine histological examination was done, together with immunohistochemistry for detection of the hippocampal learning and memory plasticity marker, namely activity regulated cytoskeletal-associated protein (Arc), and the astrocytes reactivity marker, namely glial fibrillary acidic protein (GFAP). Results:Both type 1 and 2 untreated diabetic groups showed significantly impaired cognitive performance compared to the non-diabetic group. Treating the type 1 diabetic group with insulin alone significantly improved cognitive performance, but significantly decreased GFAP and Arc compared to the untreated type 1 group. In addition, the type 2 diabetic groups showed a significant decrease in hippocampus GFAP and Arc compared to the non-diabetic groups. Blocking NMDA receptors by memantine significantly increased cognitive performance, GFAP and Arc in the type 1 insulin-memantine group compared to the type 1-insulin group and significantly increased Arc in the type 2-memantine group compared to the untreated type 2 diabetic group. The non-diabetic group receiving memantine was, however, significantly adversely affected.Conclusion:Cognitive functions are impaired in both types of diabetes mellitus and can be improved by blockage of NMDA receptors which may spark a future therapeutic role for these receptors in diabetes-associated cognitive dysfunction.
Phylogenetic analysis of the Neotropical genus Mezilaurus and reestablishment of Clinostemon (Lauraceae)
Authors: Alves Flávio Macedo , Souza Vinícius Castro 
Published: July 2013

AbstractThe delimitation of the genus Mezilaurus (Lauraceae) has always been controversial and depended on the weight given to some characters over others. This study is the first molecular phylogeny of Mezilaurus. It aims to test the monophyly of the genus and its relationships within the Mezilaurus group or other closely related genera. The Mezilaurus group had emerged as monophyletic in previous phylogenetic studies, and includes Anaueria, Chlorocardium, Mezilaurus, Sextonia, and Williamodendron. The phylogenetic analysis of Mezilaurus and related genera was based on trnH–psbA and ITS of ten species of Mezilaurus and thirteen outgroup species. Maximum parsimony and Bayesian inference were performed for each marker separately and for combined datasets. The combined analyses confirmed the monophyly of the Mezilaurus group, but did not support sister relationships of Anaueria and Chlorocardium. The Mezilauroids, containing Mezilaurus, Sextonia, and Williamodendron, formed a well–supported clade. However, the genus Mezilaurus, as currently defined, is not monophyletic and the Mezilaurus mahuba group (Mezilaurus mahuba, M. triunca) emerged as sister to Sextonia. Therefore, we suggest to remove the Mezilaurus mahuba group from Mezilaurus and re–establish it as Clinostemon. Mezilaurus and Clinostemon share rythmic branching with distally clustered leaves, bisexual flowers, three fertile stamens, representing the third androecial whorl, 2–locular anthers and a minute discoid cupule. Clinostemon, however, has stamens with downward recurved anthers and one pair of glands at the base of the filaments, while in Mezilaurus the anthers are erect and glands are absent.
Lectotypification of names of Neotropical species of Mucuna (Leguminosae: Papilionoideae: Phaseoleae)
Authors: Moura Tânia M. , Tozzi Ana Maria G.A. , Mansano Vidal F. , Lewis Gwilym P. 
Published: July 2013

AbstractSystematic studies of Neotropical species of Mucuna are relatively scarce. As a precursor to further taxonomic studies of this genus, we here propose lectotypes for seven New World taxa.
Typifications and taxonomic notes in species of Brazilian Goodyerinae and Spiranthinae (Orchidaceae) described by José Vellozo and Barbosa Rodrigues
Authors: Buzatto Cristiano Roberto , Singer Rodrigo B. , Romero-González Gustavo A. , van den Berg Cássio , Salazar Gerardo A. 
Published: July 2013

AbstractA total of 46 lectotypes, one neotype and one epitype are designated for species of Goodyerinae and Spiranthinae originally described by José Mariano da Conceição Vellozo and João Barbosa Rodrigues. Moreover, three new previously accepted names are treated as synonyms.
Genetic, cytological and morphological differentiation within the Balkan‐CarpathianSesleria rigidasensu Fl. Eur. (Poaceae): A taxonomically intricate tetraploid‐octoploid complex
Authors: Kuzmanović Nevena , Comanescu Petronela , Frajman Božo , Lazarević Maja , Paun Ovidiu , Schönswetter Peter , Lakušić Dmitar 
Published: July 2013

AbstractReconstruction of relationships among populations of the morphologically polymorphic and taxonomically intricateSesleria rigidasensu Fl. Eur. based on Amplified Fragment Length Polymorphisms (AFLPs) revealed four clearly differentiated genetic groups that did only partly follow recent taxonomic concepts, but were strictly allopatric. While some of the previously described taxa constitute distinct genetic entities, others have no taxonomic value. Synthesizing our AFLP data with ploidy‐level information obtained from all genetically investigated individuals as well as with chromosome counts revealed that tetraploid individuals prevail, while octoploids occur only withinS. filifolia. Lack of AFLP divergence between tetra‐ and octoploids suggests an autopolyploid origin of the latter. The genetic differentiation pattern was reflected by morphological differentiation, allowing for a taxonomic revision of the constituents ofS. rigidasensu Fl. Eur. resulting in recognition of the four speciesS. achtarovii,S. filifolia,S. rigida, andS. serbica.
The SALIX Method: A semi‐automated workflow for herbarium specimen digitization
Authors: Barber Anne , Lafferty Daryl , Landrum Leslie R. 
Published: July 2013

AbstractSupported by a United States American Recovery and Reinvestment Act grant, we have developed a workflow, "the SALIX Method", to image, database, and provide web access to ca. 60,000 Latin American plant specimens housed at the Arizona State University Herbarium. The SALIX Method incorporates optical character recognition using ABBYY FineReader and uses other proprietary software for word processing (Microsoft Word) and image management (Adobe Lightroom). We developed the other applications ourselves: SALIX for text parsing, and BarcodeRenamer (BCR) for renaming image files to match their barcodes. We use our Symbiota data portal (SEINet) to provide web access to collections data and images. Data entry was found to be about as fast to considerably faster using the SALIX Method than by keystroke entry directly into SEINet. Speed is dependent on label quality and length as well as user proficiency.
Molecular phylogeny of the platycodonoid group (Campanulaceae s.str.) with special reference to the circumscription of Codonopsis
Authors: Wang Qiang , Zhou Shi-Liang , Hong De-Yuan 
Published: July 2013

AbstractPhylogenetic analyses of 41 taxa representing all genera except Ostrowskia of the platycodonoid group were done using sequences of five DNA fragments from the chloroplast and nuclear genomes. The results show that the platycodonoid group is a monophyletic group, and that four major clades can be recognized: (1) the Platycodon clade with colporate pollen, including Platycodon, Canarina, Cyclocodon, and Echinocodon; (2) the Cyananthus clade with colpate pollen and a superior ovary, including only Cyananthus; (3) the long‐colpus clade with long‐colpus pollen, an inferior ovary, and a disc or glands, including Codonopsis subg. Codonopsis, Campanumoea, and Leptocodon; and (4) the short‐colpus clade with short‐colpus pollen, an inferior ovary, and without a disc or glands, including Codonopsis subg. Pseudocodonopsis, subg. Obconicicapsula, and C. purpurea of Codonopsis subg. Codonopsis. These four major clades are strongly supported and well correlated with pollen type and morphology. The results support the separation of Cyclocodon from Codonopsis as a genus. The results also indicate that Campanumoea and Leptocodon should be merged with Codonopsis, whereas all taxa of the short‐colpus clade should be separated from Codonopsis.
Evolutionary relationships in Gorteria: A re‐evaluation
Authors: Stångberg Frida , Ellis Allan G. , Anderberg Arne A. 
Published: July 2013

AbstractA molecular phylogeny of the mainly South African genus Gorteria is presented for the first time, based on Bayesian inference and parsimony analyses using DNA sequences from plastid trnL‐F and from nuclear ETS and ITS regions. It is shown that the genus is strongly paraphyletic in relation to one subgroup of Hirpicium, a finding that changes the prevailing generic concept and circumscription of Gorteria and Hirpicium. Furthermore, Gorteria diffusa and G. personata both seem to be polyphyletic assemblages, comprised of some more or less well diagnosed monophyletic groups with different distributions.
Molecular phylogenetics and character evolution of Cannabaceae
Authors: Yang Mei-Qing , van Velzen Robin , Bakker Freek T. , Sattarian Ali , Li De-Zhu , Yi Ting-Shuang 
Published: July 2013

AbstractCannabaceae includes ten genera that are widely distributed in tropical to temperate regions of the world. Because of limited taxon and character sampling in previous studies, intergeneric phylogenetic relationships within this family have been poorly resolved. We conducted a molecular phylogenetic study based on four plastid loci (atpB‐rbcL, rbcL, rps16, trnL‐trnF) from 36 ingroup taxa, representing all ten recognized Cannabaceae genera, and six related taxa as outgroups. The molecular results strongly supported this expanded family to be a monophyletic group. All genera were monophyletic except for Trema, which was paraphyletic with respect to Parasponia. The Aphananthe clade was sister to all other Cannabaceae, and the other genera formed a strongly supported clade further resolved into a Lozanella clade, a Gironniera clade, and a trichotomy formed by the remaining genera. Morphological ancestral state reconstructions indicated the complex evolution pattern of most analyzed morphological characters, and it is difficult to identify morphological synapomorphies for most clades within Cannabaceae.
Influence of physical properties of cuvette surface on measurement of serum lipase
Authors: Cattoir Lien , Pede Valerie , Decavele An-Sofie , De Buyzere Marc L. , Speeckaert Marijn M. , Seccombe David , Boterberg Veerle , Dubruel Peter , de Bisschop Frank , Delanghe Joris R. 
Published: July 2013

Abstract

Background: Despite striking similarities among colorimetric lipase assay recipes, marked intervendor differences are noted in the reported lipase values. In the present study, the effect of physical properties of the cuvette surface on measurement of serum lipase was investigated.

Methods: Lipase activity was measured concomitantly in cuvettes from three different analyzers: Vista (Siemens), Modular (Roche), and Synchron (Beckman Coulter). The surface/volume ratio of the cuvettes and the contact angle of the cuvette polymers were determined. The effects of various characteristics of serum (biochemical parameters, surface tension) were also examined.

Results: Serum lipase activities based on the colorimetric methylresorufin assay differed markedly according to the cuvettes used. More specifically, in the lower activity rate, marked differences were reported. The physical properties of the various cuvettes showed remarkable differences, especially in the contact angles. Other biochemical parameters (bilirubin, alkaline phosphatase, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, and triglycerides) and serum surface tension did not affect the results.

Conclusions: Serum lipase activity is affected by the physical properties of the cuvette surface.
Synthesis of novel 2-arylsulfonylimino-3,4- dimethyl-5-(5-S-substituted [1,3,4]oxadiazol- 2-yl)-2,3-dihydrothiazole derivatives and their plant growth stimulant activity
Authors: Eliazyan Karine A. , Hakobyan Ruzanna S. , Pivazyan Vergush A. , Ghazaryan Emma A. , Harutyunyan Siranush V. , Yengoyan Aleksandr P. 
Published: July 2013

Abstract
2-Arylsulfonylimino-3,4-dimethyl-2,3-dihydrothiazole-5-carboxylic acid hydrazides 2 were obtained from corresponding 2-arylsulfonylimino-4-methyl-2,3-dihydrothiazole-5-carboxylic acid ethyl esters 1 in a two-step synthesis. Heterocyclization of the hydrazide moiety yielded 2-arylsulfonylimino-3,4-dimethyl-5-(5-thioxo-4,5-dihydro-[1,3,4]oxadiazol-2-yl)-2,3-dihydro-thiazoles 3. Treatment of compounds 3 with various alkyl halides gave corresponding S-substituted derivatives 4–6. The plant growth stimulant activities of synthesized compounds were compared with those of similar [1,2,4]triazol- and [1,3,4,]thiadiazol-2-yl-thiazoles.
Nonlocal response in plasmonic waveguiding with extreme light confinement
Authors: Toscano Giuseppe , Raza Søren , Yan Wei , Jeppesen Claus , Xiao Sanshui , Wubs Martijn , Jauho Antti-Pekka , Bozhevolnyi Sergey I. , Mortensen N. Asger 
Published: July 2013

Abstract
We present a novel wave equation for linearized plasmonic response, obtained by combining the coupled real-space differential equations for the electric field and current density. Nonlocal dynamics are fully accounted for, and the formulation is very well suited for numerical implementation, allowing us to study waveguides with subnanometer cross-sections exhibiting extreme light confinement. We show that groove and wedge waveguides have a fundamental lower limit in their mode confinement, only captured by the nonlocal theory. The limitation translates into an upper limit for the corresponding Purcell factors, and thus has important implications for quantum plasmonics.
The Difference Between Exercise-Induced Autonomic and Fitness Changes Measured After 12 and 20 Weeks of Medium-to-High Intensity Military Training
Authors: Grant Catharina C. , Mongwe Lot , Janse van Rensburg Dina C. , Fletcher Lizelle , Wood Paola S. , Terblanche Etrisia , du Toit Peet J. 
Published: July 2013

Abstract
Grant, CC, Mongwe, L, Janse van Rensburg, DC, Fletcher, L, Wood, PS, Terblanche, E, and du Toit, PJ. The difference between exercise-induced autonomic and fitness changes measured after 12 and 20 weeks of medium-to-high intensity military training. J Strength Cond Res 30(9): 2453–2459, 2016—The aim of this study was to compare the physical fitness, based on VO2max and exercise-induced cardiac autonomic changes, measured by heart rate variability (HRV) of 12 weeks with 20 weeks of training in the South African National Defence Force. Recruits (n = 154) participated in a medium-to-high intensity exercise intervention (daily energy expenditure: 8,485 kJ·d−1). The significant effect on VO2max between weeks 1 and 12 (48.57, SD = 9.25 vs. 53.36, SD = 7.21] did not continue during weeks 12–20 (53.36, SD = 7.21 vs. 53.87, SD = 7.87). No changes in the supine low frequency (LF)/high frequency (HF) (0.48, SD = 0.51 vs. 0.41, SD = 0.64) or the standing LF/HF (4.02, SD = 5.14 vs. 3.91, SD = 5.28), an indicator of autonomic balance and a possible indicator of overtraining syndrome, suggests that overtraining did not take place during weeks 12–20. This was confirmed with further decreases in supine and standing heart rate. However, the power of the vagal-induced variability continued to increase after 12 weeks. Increased vagal influence without concurrent change in autonomic balance may be interpreted as decreased sympathetic cardiac control. It is important to note that although no fitness changes were detected, positive cardiac autonomic conditioning did continue between weeks 12 and 20, as measured by increased vagal-induced HRV and decreased sympathetic influence on cardiac control. Results may be extrapolated to training in the normal population/athletes after a medium-to-high intensity exercise program, as this intervention was a closely monitored and standardized exercise program.