bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Study on Placental and Umbilical Cord Morphology in Mothers with Pre-Eclampsia and its Correlation with Fetal Outcome at Birth in a Tertiary Care Hospital
Authors: sinha Sweta , kumar Pravin , Chattopadhyay Nibedita , Sengupta Mini 
Published: August 2024

Abstract

INTRODUCTION
The placenta is a distinctive characteristic of higher mammals which is attached to the uterus and is connected to the foetus through the umbilical cord. The placenta is an organ of vital importance for the continuation of a pregnancy and fetal nutrition. In humans, after the birth of the infant, placenta is often disposed soon after parturition without adequate examination. It has been seen that many disorders of the pregnancy are associated with gross anatomical, physiological, and pathological changes in the placenta. Hypertension is one of the common complications met with in pregnancy and contributes significantly to maternal and perinatal morbidity and mortality. Of the few studies that have explored the subject, it has been seen that morphologically, the placentae of hypertensive disorders of pregnancy are smaller, with lesser weight, diameter, and thickness as compared to placentae of normal women. Even fewer studies have been done which have correlated these altered placental findings with foetal and neonatal outcomes.
OBJECTIVE
Here we did a study on placental and umbilical cord morphology in mothers with pre-eclampsia and its correlation with fetal outcome at birth in a tertiary care hospital.
MATERIAL AND METHODS
The study population consisted of women of gestational age > 34 weeks with diagnosed pregnancy induced hypertension or pre-eclampsia who were admitted to the labour room of the study institution for delivery.
CONCLUSION
Mothers with hypertensive disorders of pregnancy tend to have a high incidence of abnormal placental and umbilical cord morphology at delivery such as lower placental weight, diameter, thickness, lower umblical cord weight, diameter, and length
Excellent Electromagnetic Interference Shielding of Multi-layered Thermoplastic Poly- urethane Nanocomposites with CoFe 2 O 4 Nanoparticles and Graphite
Authors: Wilson Nithiya Hanna , N/A Anju , Masař Milan , Machovský Michal , Škoda David , Urbánek Pavel , Urbánek Michal , Pöschl Marek , Vilčáková Jarmila , Kuřitka Ivo , Yadav Raghvendra Singh 
Published: August 2024

Abstract

This work presents multi-layered polymer-based nanocomposites that effectively block electromagnetic (EM) radiation by including magnetic and conductive fillers. The sonochemical method produced CoFe2O4 nanoparticles with a high degree of purity. The melt mixing process followed by compression moulding was utilized to generate individual layers of thermoplastic polyurethane (TPU) containing conductive graphite (G-TPU) or magnetic CoFe2O4 spinel ferrite nanoparticles (F-TPU) at a thickness of around 0.8 mm. Additionally, to create TPU-based multi-layered nanocomposites, three mono-layers of either F-TPU or G-TPU were stacked in an identical and alternating fashion. These were designated as F-TPU/F-TPU/F-TPU, G-TPU/G-TPU/G-TPU, F-TPU/G-TPU/F-TPU, and G-TPU/F-TPU/G-TPU which were further briefly represented as F/F/F, G/G/G, F/G/F, and G/F/G, respectively. The electromagnetic interference (EMI) total shielding effectiveness (SET) in the X-band frequency range of 8.2–12.4 GHz was investigated and observed to be 3.7 dB, 33.8 dB, 23.9 dB, and 54.0 dB for F/F/F, G/G/G, F/G/F, and G/F/G, respectively. This research offers a guide for engineers looking to create superior EMI shielding polymer nanocomposites, which have potential uses in radar security and information communications.
Enhancing Economic Efficiency Through the Implementation of Home Parenteral Nutrition SOP with a Novel Training Module
Authors: Wang Jaw-Yuan , Su Wei-Chih , Chang Tsung-Kun , Chen Yen-Cheng , Huang Ching-Wen , Yeh Yung-Sung , Chen Po-Jung , Yin Tzu-Chieh , Tsai Hsiang-Lin , Sun Li-Chu 
Published: August 2024

Abstract

Background
Home parenteral nutrition (HPN) is essential in providing nutrition and hydration to appropriately selected patients who cannot receive adequate oral or enteral nutrition. This study investigated the implementation of HPN at our institution, following our standardized operating procedures (SOP) and the utilization of the Port-A auxiliary device model.
Methods
This was a retrospective observational study that enrolled adult and pediatric patients undergoing HPN. The patients were supervised by the Nutrition Therapy Team of a single institution from January 2020 to December 2022.
Results
Results indicated substantial improvements in operational efficiency and patient outcomes. Specifically, the integration of our hospital’s SOP and the use of the auxiliary device led to a notable reduction in nursing workload hours in terms of providing HPN education (mean reduction of 36.2 hours) and shortened patient hospital stays (mean reduction of 2.9 days), suggesting that these interventions can lead to a streamlined, efficient, and safe HPN administration. Furthermore, the HPN protocol of our institution led to significant direct and indirect cost savings, signifying its potential to alleviate the financial burden of Taiwan’s healthcare system. Lastly, HPN at our institution is safe, with the incidences of adverse events of special interest generally showing a decreasing trend during the study period.
Conclusions
The study demonstrates that integrating the SOP of Kaohsiung Medical University Hospital and using the Port-A auxiliary device for HPN therapy substantially enhances operational efficiency, cost savings, and patient outcomes.
Severe hypoglycemia with Hyperprolinemia and Pituitary Stalk Interruption Syndrome in a 5-year-old boy: A Case Report and Literature Review
Authors: Theodosiadi Aikaterini , Toulia Ilektra , Grammatikopoulou Maria G , Adamidou Fotini , Chourmouzi Danai , Evangeliou Athanasios E , Goulis Dimitrios G , Tsiroukidou Kyriaki 
Published: August 2024

Abstract

Background: Hyperprolinemia is a rare autosomal recessive disorder with two distinct types: I (HPI) and II (HPII). The clinical presentation varies widely, with some individuals remaining asymptomatic and others exhibiting neurological, renal or auditory defects and seizures. However, it has never been associated with hypoglycemia. The present case report describes a boy with HPII, with an episode of severe hypoglycemia and Pituitary Stalk Interruption Syndrome (PSIS) with isolated growth hormone (GH) deficiency (GHD).
Case presentation: A 5-year and 6/12-month-old boy presented to the Department of Pediatric Endocrinology for routine thyroid function assessment due to hypothyroidism. He was diagnosed as having HPII at the age of 2 years during an investigation for seizure episodes. Clinically, the boy exhibited attention deficit hyperactivity disorder (ADHD) and a reduction in growth velocity (1.6 cm/year). Hematological and biochemical analyses were within the reference range. Hormone profiling revealed lower-than-expected insulin-like growth factor-1 (IGF-1) concentrations, prompting a GH stimulation test, which, in turn, revealed GHD. Brain magnetic resonance imaging (MRI) showed features consistent with PSIS. Noteworthy is the occurrence of severe hypoglycemia during the evaluation, leading to hospitalization, eventually attributed to GHD. Following the exogenous administration of recombinant human GH, the boy exhibited increased growth velocity, with no adverse events over the follow-up period.
Conclusion: Hyperprolinemia is a rare condition; in this context, the occurrence of severe hypoglycemia accompanied by a low growth velocity poses a challenge for the clinical pediatrician.
Impact of Mechanical Ventilation and Anesthesia on PET Tracer Kinetics for Combined PET/fMRI Studies in Rats
Authors: Ma Yan , Kuebler Laura , Haas Sabrina , Maurer Andreas , Herfert Kristina 
Published: August 2024

Abstract

Purpose
Positron Emission Tomography (PET), a crucial tool in molecular brain imaging, has evolved into hybrid system through integration with functional MRI (fMRI). This advancement facilitates simultaneous recording of molecular and functional data in animal models, offering in-sights into neuroreceptor and neurotransmitter dynamics and their effects on brain function. While mechanical ventilation is often used in small animal fMRI to stabilize physiological blood gas levels, its effects on PET tracer kinetics remain underexplored.
Procedures:
This study examines the kinetics of [11C]raclopride, a dopamine-sensitive PET tracer targeting D2/D3 receptors, under various respiratory conditions and anesthesia protocols frequently used in small animal fMRI and PET.
Results
Results indicate significant variations in tracer kinetics: increased peak levels, a shorter time to peak, and a faster tracer equilibrium in the striatum-cerebellum distribution volume ratio were observed in spontaneously breathing animals versus those under mechanical ventilation. Anesthesia type also strongly influenced the tracer kinetics: α-chloralose anesthesia reduced brain uptake, whereas isoflurane led to a more rapid equilibrium.
Conclusions
These findings underscore the profound impact of mechanical ventilation and anesthesia selection on PET tracer kinetics in hybrid PET/fMRI studies. The study highlights that those protocols established for fMRI are not directly transferable to PET imaging in small animals, emphasizing the necessity for a careful investigation of the influence of anesthesia and ventilation techniques on tracer kinetics.
Acylcarnitines metabolism in depression: association with diagnostic status, depression severity and symptom profile in the NESDA cohort
Authors: milaneschi yuri , Montanari Silvia , Jansen Rick , Schranner Daniela , Kastenmüller Gabi , Arnold Matthias , Janiri Delfina , Sani Gabriele , Bhattacharyya Sudeepa , Dehkordi Siamak Mahmoudian , Dunlop Boadie , Rush Augustus , penninx brenda , Kaddurah-Daouk Rima 
Published: August 2024

Abstract

Acylcarnitines (ACs) are involved in bioenergetics processes that may play a role in the pathophysiology of depression. Previous genomic evidence identified four ACs potentially linked to depression risk. We carried forward these ACs and tested the association of their circulating levels with Major Depressive Disorder (MDD) diagnosis, overall depression severity and specific symptom profiles. The sample from the Netherlands Study of Depression and Anxiety included participants with current (n = 1035) or remitted (n = 739) MDD and healthy controls (n = 800). Plasma levels of four ACs (short-chain: acetylcarnitine C2 and propionylcarnitine C3; medium-chain: octanoylcarnitine C8 and decanoylcarnitine C10) were measured. Overall depression severity as well as atypical/energy-related (AES), anhedonic and melancholic symptom profiles were derived from the Inventory of Depressive Symptomatology. As compared to healthy controls, subjects with current or remitted MDD presented similarly lower mean C2 levels (Cohen’s d = 0.2, p ≤ 1e-4). Higher overall depression severity was significantly associated with higher C3 levels (ß=0.06, SE = 0.02, p = 1.21e-3). No associations were found for C8 and C10. Focusing on symptom profiles, only higher AES scores were linked to lower C2 (ß=-0.05, SE = 0.02, p = 1.85e-2) and higher C3 (ß=0.08, SE = 0.02, p = 3.41e-5) levels. Results were confirmed in analyses pooling data with an additional internal replication sample from the same subjects measured at 6-year follow-up (totaling 4141 observations). Small alterations in levels of short-chain acylcarnitine levels were related to the presence and severity of depression, especially for symptoms reflecting altered energy homeostasis. Cellular metabolic dysfunctions may represent a key pathway in depression pathophysiology potentially accessible through AC metabolism.
A Qualitative Study Exploring Patients Experience of Emergency Healthcare Utilisation during the Covid-19 Pandemic.
Authors: FitzGerald Christine , Bounds Megan , Barry Louise , Corey Gillian , Devlin Collette , Ryan Damian , Cummins Fergal , Galvin Rose , Cummins Niamh 
Published: August 2024

Abstract

Background
COVID-19 caused a global pandemic, disrupting healthcare services and contributing to significant mortality and morbidity worldwide. This necessitated high-quality care to be balanced with infection control in Emergency Department (ED) setting, compounding existing challenges for both healthcare professionals and patients. The aim of this study was to explore the experiences of adults who attended EDs across Ireland during the COVID-19 pandemic. Study findings will enhance understanding of patient’s experiences of ED attendance during COVID-19 and add to the evidence which explores the impact of Covid-19 on patient care.
Methods
This study utilises a subset of the Better Data Better Planning study [1] consisting of 46 interviews from 4 Regional Hospital Sites across Ireland. A qualitative research design comprising of semi-structured interviews was used for this study.
Results
Two key themes were produced from the data; Sense of reassurance in the ED during COVID-19 and COVID-19 impact on ED attendance and discharge experience.
Conclusions
This paper provides tangible insights into the experiences of ED patients during Covid-19 Notably, the importance of staff reassurance, where along with PPE use, reconfiguration of the ED environment and communication were found to alleviate patients concerns regarding exposure and transmission risks of Covid-19 while being present in the ED during the pandemic.
The influence of Lactobacillus johnsonii on tumor growth and lymph node metastasis in papillary thyroid carcinoma
Authors: Min Xiang , Xie Minghao , Yang Tingting , Liu Qiang , Ning Zhikun , Feng Lili 
Published: August 2024

Abstract

The presence of lymph node metastasis (LNM) is one of the most crucial factors in the prognosis of papillary thyroid carcinoma (PTC). The aim of this study was to investigate the influence of intratumoral bacteria on the LNM in PTC. The intrathyroidal microbiome was analyzed in 55 PTC patients by 16S rRNA gene sequencing. The CCK8 and Transwell assays were conducted to determine the impact of bacteria on the proliferation and migration abilities of PTC cells. Xenograft tumor and bacterial colonization experiments were carried out using nude mice. We showed that Lactobacillus was significantly decreased in PTC lesions from patients with LNM. Lactobacillus johnsonii (L. johnsonii) could suppress the proliferation and migration capability of PTC cells in vitro and in vivo. Bacterial gut colonization of L. johnsonii increased its abundance in tumors and inhibited PTC growth and LNM. These findings suggested that L. johnsonii could be harnessed for the development of innovative therapeutic strategies for PTC.
Protective and Risk Factors in Daily Life Associated with Cognitive Decline of Older Adults
Authors: Tong Fang , Yang Hao , Yu Hai-dong , Sui Le-wen , Yao Jing-yuan , Shi Chen-lei , Yao Qiao-yuan , Shi Mei-fang , Qian Cheng-lang , Li Gang , Zhao Chao , Wang Hui-jing 
Published: August 2024

Abstract

Background: Cognitive decline is a chronic condition which is characterized by a loss of the ability to remember, learn, and pay attention to complex tasks. Many older people are now suffering from cognitive decline, which decreases life quality and leads to disability. This study aimed to identify the risk and protective factors for cognitive decline of the older people from daily life and establish a predictive model using logistic regression.
Methods: We investigated 3,790 older people with health examination and questionnaires which included information associated with physical condition, lifestyle factors, and cognitive status. Single-factor comparison, principal component analysis with a Manova-Wilk test, and logistic regression were performed to filter the risk and protective factors regarding cognitive decline of older individuals.
Results: We found a significant separation along the coordinate axis between people with normal and declined cognition by principal component analysis, as confirmed by the Manover-Wilk test. Single-factor comparison and logistic regression demonstrated significant difference in gender, age, hypertension level, height, dietary habit, physical-exercise duration, physical-exercise history, and smoking history between the two groups. We also observed significant differences in height, physical exercise duration, physical-exercise years, and smoking years between the male and female of the participants. ROCs of the predictive model by logistic regression were plotted, with AUC values of 0.683 and 0.682 respectively for the training and testing sets.
Conclusion: The protective factors of cognitive decline for older people were male gender, height, keeping exercising, and nicotine stimulation, and the risk factors included age, female gender, vegetarianism, hypertension, and over-exercise. Except for the genetic factor, differences in lifestyle, such as smoking and exercise habits, may contribute to the observed differences in cognitive function between genders.
Transforming dementia research into practice: A multiple case study of academic research utilization strategies in Dutch Alzheimer Centers
Authors: Zhu Eden Meng , Buljac-Samardžić Martina , Ahaus Kees , Huijsman Robbert 
Published: August 2024

Abstract

Background
Non-pharmacological dementia research products generated in traditional university settings, such as social and behavioral interventions, often experience challenges to impact practices that they were developed for. The Netherlands established five specialized academic health science centers, referred to as Alzheimer Centers, to structurally coordinate and facilitate the utilization of dementia research knowledge. This study leverages implementation science to systematically explore the research utilization strategies used by academic researchers from each Alzheimer Center, based on the ‘knowledge-to-action’ (KTA) framework, which includes knowledge creation, adaptation, dissemination, and implementation.
Methods
Individual semi-structured qualitative interviews were conducted with 29 respondents across the five Alzheimer Centers in the Netherlands, selected through purposive (snowball) sampling. Interviews were conducted in-person and virtually through Microsoft Teams, and all were audio-recorded and transcribed verbatim. Data analysis was guided by the dimensions of the KTA framework.
Result
There was a high variation in the strategies used across the five Alzheimer Centers to bring non-pharmacological dementia research into practice, and selected strategies in each Center were influenced by the typology of research products produced and the Centers’ organizational heritage. The knowledge creation and adaptation phases were mainly facilitated by funders’ guidance toward research impact and research product co-creation with patients and implementing organizations. Dissemination and implementation phases were often facilitated through utilizing support from university-based technology transfer offices to facilitate implementation and valorization and establishing and strategically leveraging formal infrastructure, such as public-private partnerships and professional collaborative networks.
Conclusion
Successful research utilization requires evolving researcher competencies to meet environmental demands and facilitating co-creation with research end-users and implementing partners. Understanding external determinants influencing research utilization in the Dutch dementia research ecosystem is crucial for capacity-building and aligning cross-sector agendas. The KTA framework appears to reveal the intricacies of research utilization, guiding future studies to explore strategies employed across various contexts.
Effect of artesunate on the expression of ICAM-1 and MMP-9 in vascular endothelial cells under high glucose conditions
Authors: Ge Pengfei , Jiang Tao , Zong Yao , Lu Susu , Yang Xuejiao , Xu Xinyan , Fan Xiaojun , Song Liping , Yang Yunxiao , Sun Zhe 
Published: August 2024

Abstract

Background Diabetic retinopathy (DR) is the most common cause of diabetes-induced microvascular complications and it is the leading cause of blindness in working age worldwide. At the present stage,The main treatment for neovascularization and leakage in DR is anti-VEGF therapy, however, anti-VEGF therapy has its limitation,such as single target and short half-life of anti-VEGF drugs. Therefore, clarifying more therapeutic targets according to the molecular mechanism of neovascularization and leakage is needed, treating the disease by a drug which is multi-target and long-acting. Previous studies have shown that artesunate (ART) can inhibit retinal neovascularization and leakage through multiple targets. This study aimed to clarify the new mechanism of ART inhibiting retinal neovascularization and leakage.
Objective To investigate the new mechanism of retinal neovascularization and leakage inhibited by artesunate (ART) .
Methods Human Umbilical Vein Endothelial Cells (HUVEC) were divided into glucose (G) group, 40mmol/L G+ART(G40+ART)group, mannitol (M) control group, dimethyl sulfoxide (DMSO)control group. The concentration gradient of G group is 5.5mmol/L G (G5.5), 25mmol/L G (G25), 40mmol/L G (G40); The concentration gradient of M control group is 5.5 mmol / L G + 19.5 mmol / L M (M25), 5.5 mmol / L G + 34.5 mmol / L M (M40), The concentration gradient of ART of G40 + ART group is G40 + 10ug /ml ART(10A), G40+20ug/ml ART(20A), G40+40ug/ml ART(40A); the volume of DMSO in the DMSO control group is the same as it is in the 40A group. Western blot,and cell Immunofluorescence technique were used to detect the protein expression of ICAM-1 and MMP-9 in each group.
Results Western blot,and cell Immunofluorescence showed that the protein expression of Intercellular adhesion molecule-1（ICAM-1）and Matrix metalloproteinase-9（MMP-9）in G25 group was higher than that in G5.5 group (P<0.01), and it increased in G40 group compared with G25 group (P<0.01);The protein expression of ICAM-1 and MMP-9 in G25 group was higher than that of M25 group (P<0.01),and it increased in G40 group compared with M40 (P<0.01);the protein expression of ICAM-1 and MMP-9 of G40+ART group was lower than that of G40 group,in which,it was lower in 20A group than that of 10A group (P<0.01), and it was lower in 40A group compared with 20A group (P<0.01). The DMSO control group showed that the protein expression of ICAM-1 and MMP-9 in G40+ART was lower than that of G40+DMSO group (P<0.01).
Conclusion The two targets of ICAM-1 and MMP-9 may act as new therapeutic targets of ART to suppress the retinal neovascularization and leakage in DR,offering assistance for ART used in DR to treat the neovascularization and leakage.