bluuebunny/crossref_metadata_2025_split huggingface dataset:
Do socioeconomic factors influence breast cancer screening practices among Arab women in Qatar?
Authors: Donnelly Tam Truong , Al Khater Al-Hareth , Al Kuwari Mohamed Ghaith , Al-Bader Salha Bujassoum , Al-Meer Nabila , Abdulmalik Mariam , Singh Rajvir , Chaudhry Sofia , Fung Tak 
Published: January 2015

ObjectivesBreast cancer incidence rates are rising in Qatar. Although the Qatari government provides subsidised healthcare and screening programmes that reduce cost barriers for residents, breast cancer screening (BCS) practices among women remain low. This study explores the influence of socioeconomic status on BCS among Arab women in Qatar.SettingA multicentre, cross-sectional quantitative survey was conducted with 1063 Arab women (87.5% response rate) in Qatar from March 2011 to July 2011. Women who were 35 years or older and had lived in Qatar for at least 10 years were recruited from seven primary healthcare centres and women's health clinics in urban and semiurban regions of Qatar. Associations between socioeconomic factors and BCS practice were estimated using χ2tests and multivariate logistic regression analyses.ResultsFindings indicate that less than one-third of the participants practised BCS appropriately, whereas less than half of the participants were familiar with recent BCS guidelines. Married women and women with higher education and income levels were significantly more likely to be aware of and to practise BCS than women who had lower education and income levels.ConclusionsFindings indicate low levels of awareness and low participation rates in BCS among Arab women in Qatar. Socioeconomic factors influence these women's participation in BCS activities. The strongest predictors for BCS practice are higher education and higher income levels.RecommendationsAdditional research is needed to explore the impact of economic factors on healthcare seeking behaviours in the Middle Eastern countries that have a high national gross domestic product where healthcare services are free or heavily subsidised by the government; promotion of BCS and intervention strategies in these countries should focus on raising awareness about breast cancer, the cost and benefit of early screening for this disease, particularly among low-income women.
Prognostic role of microRNA-205 in multiple human malignant neoplasms: a meta-analysis of 17 studies
Authors: Zhang Jia-yi , Sun Meng-yan , Song Ning-hong , Deng Zhong-lei , Xue Chun-yu , Yang Jie 
Published: January 2015

ObjectiveMicroRNA-205 (miRNA-205) was revealed as an attractive prognostic tumour biomarker in recent studies. However, the results of different studies have been inconsistent. We conducted a meta-analysis to elucidate the precise predictive value of miRNA-205 in various human malignant neoplasms.DesignMeta-analysis.Data sourcesQualified studies were identified up to 5 June 2014 by performing online searches in PubMed, EMBASE and Web of Science, and additional quality evaluations.ParticipantsSeventeen eligible studies with 4827 patients were ultimately enrolled in this meta-analysis.Outcome measuresThe heterogeneity between studies was assessed using I2statistics. Pooled HRs with 95% CIs for patient survival and disease recurrence were calculated to investigate the correlation between miRNA-205 expression and cancer prognosis.ResultsOur results indicate that elevated miRNA-205 was significantly associated with enhanced overall survival in the breast cancer subgroup (HR=0.78, 95% CI 0.67 to 0.91) and superior disease-free survival/recurrence-free survival in the adenocarcinoma subgroup (HR=0.68, 95% CI 0.49 to 0.94).ConclusionsmiRNA-205 is a promising biomarker for predicting the recurrence and progression of patients with adenocarcinomas or breast cancer. Owing to its complex roles, further relevant studies are warranted.
Cell Division Patterns in Acute Myeloid Leukemia Stem-like Cells Determine Clinical Course: A Model to Predict Patient Survival
Authors: Stiehl Thomas , Baran Natalia , Ho Anthony D. , Marciniak-Czochra Anna 
Published: January 2015

Abstract
Acute myeloid leukemia (AML) is a heterogeneous disease in which a variety of distinct genetic alterations might occur. Recent attempts to identify the leukemia stem-like cells (LSC) have also indicated heterogeneity of these cells. On the basis of mathematical modeling and computer simulations, we have provided evidence that proliferation and self-renewal rates of the LSC population have greater impact on the course of disease than proliferation and self-renewal rates of leukemia blast populations, that is, leukemia progenitor cells. The modeling approach has enabled us to estimate the LSC properties of 31 individuals with relapsed AML and to link them to patient survival. On the basis of the estimated LSC properties, the patients can be divided into two prognostic groups that differ significantly with respect to overall survival after first relapse. The results suggest that high LSC self-renewal and proliferation rates are indicators of poor prognosis. Nevertheless, high LSC self-renewal rate may partially compensate for slow LSC proliferation and vice versa. Thus, model-based interpretation of clinical data allows estimation of prognostic factors that cannot be measured directly. This may have clinical implications for designing treatment strategies. Cancer Res; 75(6); 940–9. ©2015 AACR.
Projecting Benefits and Harms of Novel Cancer Screening Biomarkers: A Study of PCA3 and Prostate Cancer
Authors: Birnbaum Jeanette K. , Feng Ziding , Gulati Roman , Fan Jing , Lotan Yair , Wei John T. , Etzioni Ruth 
Published: January 2015

Abstract
Background: New biomarkers for early detection of cancer must pass through several phases of development. Early phases provide information on diagnostic properties but not on population benefits and harms. Prostate cancer antigen 3 (PCA3) is a promising prostate cancer biomarker still in early development. We use simulation modeling to project the impact of adding PCA3 to prostate-specific antigen (PSA) screening on prostate cancer detection and mortality in the United States.
Methods: We used data from a recent study of PCA3 in men referred for prostate biopsy to extend an existing simulation model of PSA growth, disease progression, and survival. We specified several PSA-PCA3 strategies designed to improve specificity and reduce overdiagnosis. Using these strategies to screen a cohort of men biennially between ages 50 and 74, we projected true- and false-positive tests, overdiagnoses, and lives saved relative to a PSA-based strategy with a cutoff of 4.0 ng/mL for biopsy referral.
Results: We identified several PSA-PCA3 strategies that substantially reduced false-positive tests and overdiagnoses while preserving the majority of lives saved. PCA3&gt;35 for biopsy referral in men with PSA between 4.0 and 10.0 ng/mL retained 85% of lives saved while approximately halving false positives and reducing overdiagnoses by 25%.
Conclusions: Adding PCA3 to PSA screening can significantly reduce adverse screening outcomes. Strategies can be identified that preserve most of the lives saved relative to PSA-based screening.
Impact: Simulation modeling provides advance projections of population outcomes of new screening biomarkers and may help guide early detection research. Cancer Epidemiol Biomarkers Prev; 24(4); 677–82. ©2015 AACR.
Low-Dose CT Lung Cancer Screening Practices and Attitudes among Primary Care Providers at an Academic Medical Center
Authors: Lewis Jennifer A. , Petty W. Jeffrey , Tooze Janet A. , Miller David P. , Chiles Caroline , Miller Antonius A. , Bellinger Christina , Weaver Kathryn E. 
Published: January 2015

Abstract
Background: Low-dose computed tomography (LDCT) screening reduces lung cancer–specific and overall mortality. We sought to assess lung cancer screening practices and attitudes among primary care providers (PCPs) in the era of new LDCT screening guidelines.
Methods: In 2013, we surveyed PCPs at an academic medical center (60% response) and assessed: lung cancer screening use, perceived screening effectiveness, knowledge of screening guidelines, perceived barriers to LDCT use, and interest in LDCT screening education.
Results: Few PCPs (n = 212) reported ordering lung cancer screening: chest X-ray (21%), LDCT (12%), and sputum cytology (3%). Only 47% of providers knew three or more of six guideline components for LDCT screening; 24% did not know any guideline components. In multiple logistic regression analysis, providers who knew three or more guideline components were more likely to order LDCT (OR, 7.1; 95% confidence intervals, 2.0–25.6). Many providers (30%) were unsure of the effectiveness of LDCT. Mammography, colonoscopy, and Pap smear were rated more frequently as effective in reducing cancer mortality compared with LDCT (all P values &lt; 0.0001). Common perceived barriers included patient cost (86.9% major or minor barrier), harm from false positives (82.7%), patients' lack of awareness (81.3%), risk of incidental findings (81.3%), and insurance coverage (80.1%).
Conclusions: LDCT lung cancer screening is currently an uncommon practice at an academic medical center. PCPs report ordering chest X-ray, a nonrecommended screening test, more often than LDCT. PCPs had a limited understanding of lung cancer screening guidelines and LDCT effectiveness. Provider educational interventions are needed to facilitate shared decision-making with patients.
Impact: This study describes some of the first data available about PCPs' use of lung cancer screening tests since the publication of multiple professional guidelines endorsing LDCT. Knowledge gaps were identified that may hinder the uptake of evidence-based lung cancer screening guidelines. Cancer Epidemiol Biomarkers Prev; 24(4); 664–70. ©2015 AACR.
Synovial Sarcoma: Recent Discoveries as a Roadmap to New Avenues for Therapy
Authors: Nielsen Torsten O. , Poulin Neal M. , Ladanyi Marc 
Published: January 2015

Abstract
Oncogenesis in synovial sarcoma is driven by the chromosomal translocation t(X,18; p11,q11), which generates an in-frame fusion of the SWI/SNF subunit SS18 to the C-terminal repression domains of SSX1 or SSX2. Proteomic studies have identified an integral role of SS18–SSX in the SWI/SNF complex, and provide new evidence for mistargeting of polycomb repression in synovial sarcoma. Two recent in vivo studies are highlighted, providing additional support for the importance of WNT signaling in synovial sarcoma: One used a conditional mouse model in which knockout of β-catenin prevents tumor formation, and the other used a small-molecule inhibitor of β-catenin in xenograft models.
Significance: Synovial sarcoma appears to arise from still poorly characterized immature mesenchymal progenitor cells through the action of its primary oncogenic driver, the SS18–SSX fusion gene, which encodes a multifaceted disruptor of epigenetic control. The effects of SS18–SSX on polycomb-mediated gene repression and SWI/SNF chromatin remodeling have recently come into focus and may offer new insights into the basic function of these processes. A central role for deregulation of WNT–β-catenin signaling in synovial sarcoma has also been strengthened by recent in vivo studies. These new insights into the the biology of synovial sarcoma are guiding novel preclinical and clinical studies in this aggressive cancer. Cancer Discov; 5(2); 124–34. ©2015 AACR.
Wnt16 Attenuates TGFβ-Induced Chondrogenic Transformation in Vascular Smooth Muscle
Authors: Beazley Kelly E. , Nurminsky Dmitry , Lima Florence , Gandhi Chintan , Nurminskaya Maria V. 
Published: January 2015

Objective—
Phenotypic plasticity of vascular smooth muscle cells (VSMCs) contributes to cardiovascular disease. Chondrocyte-like transformation of VSMCs associates with vascular calcification and underlies the formation of aortic cartilaginous metaplasia induced in mice by genetic loss of matrix Gla protein (MGP). Previous microarray analysis identified a dramatic downregulation of Wnt16 in calcified MGP-null aortae, suggesting an antagonistic role for Wnt16 in the chondrogenic transformation of VSMCs.

Approach and Results—
Wnt16 is significantly downregulated in MGP-null aortae, before the histological appearance of cartilaginous metaplasia, and in primary MGP-null VSMCs. In contrast, intrinsic TGFβ is activated in MGP-null VSMCs and is necessary for spontaneous chondrogenesis of these cells in high-density micromass cultures. TGFβ3-induced chondrogenic transformation in wild-type VSMCs associates with Smad2/3-dependent Wnt16 downregulation, but Wnt16 does not suppress TGFβ3-induced Smad activation. In addition, TGFβ3 inhibits Notch signaling in wild-type VSMCs, and this pathway is downregulated in MGP-null aortae. Exogenous Wnt16 stimulates Notch activity and attenuates TGFβ3-induced downregulation of Notch in wild-type VSMCs, prevents chondrogenesis in MGP-null and TGFβ3-treated wild-type VSMCs, and stabilizes expression of contractile markers of differentiated VSMCs.

Conclusions—
We describe a novel TGFβ-Wnt16-Notch signaling conduit in the chondrocyte-like transformation of VSMCs and identify endogenous TGFβ activity in MGP-null VSMCs as a critical mediator of chondrogenesis. Our proposed model suggests that the activated TGFβ pathway inhibits expression of Wnt16, which is a positive regulator of Notch signaling and a stabilizer of VSMC phenotype. These data advance the comprehensive mechanistic understanding of VSMC transformation and may identify a novel potential therapeutic target in vascular calcification.
Clinically Significant Novel Biomarkers for Prediction of First Ever Myocardial Infarction
Authors: Wilsgaard Tom , Mathiesen Ellisiv Bøgeberg , Patwardhan Anil , Rowe Michael W. , Schirmer Henrik , Løchen Maja-Lisa , Sudduth-Klinger Julie , Hamren Sarah , Bønaa Kaare Harald , Njølstad Inger 
Published: January 2015

Background—
Identification of individuals with high risk for first-ever myocardial infarction (MI) can be improved. The objectives of the study were to survey multiple protein biomarkers for association with the 10-year risk of incident MI and identify a clinically significant risk model that adds information to current common risk models.

Methods and Results—

We used an immunoassay platform that uses a sensitive, sample-efficient molecular counting technology to measure 51 proteins in samples from the fourth survey (1994) in the Tromsø Study, a longitudinal study of men and women in Tromsø, Norway. A case control design was used with 419 first-ever MI cases (169 females/250 males) and 398 controls (244 females/154 males). Of the proteins measured, 17 were predictors of MI when considered individually after adjustment for traditional risk factors either in men, women, or both. The 6 biomarkers adjusted for traditional risk factors that were selected in a multivariable model (odds ratios [OR] per standard deviation) using a stepwise procedure were apolipoprotein B/apolipoprotein A1 ratio (1.40), kallikrein (0.73), lipoprotein a (1.29), matrix metalloproteinase 9 (1.30), the interaction term IP-10/CXCL10×women (0.69), and the interaction term thrombospondin 4×men (1.38). The composite risk of these biomarkers added significantly to the traditional risk factor model with a net reclassification improvement of 14% (
P
=0.0002), whereas the receiver operating characteristic area increased from 0.757 to 0.791,
P
=0.0004.

Conclusions—
Novel protein biomarker models improve identification of 10-year MI risk above and beyond traditional risk factors with 14% better allocation to either high or low risk group.
Indicator species and seasonal succession of planktonic copepod assemblages driven by the interplay of subtropical and temperate waters in the southern East China Sea
Authors: Tseng Li-Chun , Hung Jia-Jang , Molinero Juan Carlos , Chen Qing-Chao , Hwang Jiang-Shiou 
Published: January 2015

The northeastern region off Taiwan exhibits a high marine diversity favoured by the influence of northern and subtropical water masses driven by the East China Sea Water and the Kuroshio current (KC), respectively. A total of 87 species of copepods representing 36 genera were identified in present study. Calanoida was the most dominant order, while Temora turbinata (Dana, 1849), Paracalanus parvus (Claus, 1863) and Ditrichocorycaeus affinis (McMurrich, 1916) appeared as most dominant species. However, we noticed the unusual presence of the copepod Calanoides philippinensis Kitou & Tanaka, 1969 in concurrence with the dominant influence of KC, which suggests a larger intrusion of South China Sea (SCS) waters into the northeast Taiwan region. C. philippinensis is an exclusive species of the warm subtropical Pacific waters. Its presence in the northern Taiwan region may reflect a larger intrusion of warm SCS waters. We therefore suggest its potential use as a bioindicator of southern, tropical waters in the northern Taiwan area.
Revisiting the 26.5°C Sea Surface Temperature Threshold for Tropical Cyclone Development
Authors: McTaggart-Cowan Ron , Davies Emily L. , Fairman Jonathan G. , Galarneau Thomas J. , Schultz David M. 
Published: January 2015

Abstract
A high sea surface temperature is generally accepted to be one of the necessary ingredients for tropical cyclone development, indicative of the potential for surface heat and moisture fluxes capable of fueling a self-sustaining circulation. Although the minimum 26.5°C threshold for tropical cyclogenesis has become a mainstay in research and education, the fact that a nonnegligible fraction of storm formation events (about 5%) occur over cooler waters casts some doubt on the robustness of this estimate. Tropical cyclogenesis over subthreshold sea surface temperatures is associated with low tropopause heights, indicative of the presence of a cold trough aloft. To focus on this type of development environment, the applicability of the 26.5°C threshold is investigated for tropical transitions from baroclinic precursor disturbances in all basins between 1989 and 2013. Although the threshold performs well in the majority of cases without appreciable environmental baroclinicity, the potential for development is underestimated by up to 27% for systems undergoing tropical transition. An alternative criterion of a maximum 22.5°C difference between the tropopause-level and 850-hPa equivalent potential temperatures (defined as the coupling index) is proposed for this class of development. When combined with the standard 26.5°C sea surface temperature threshold for precursor-free environments, error rates are reduced to 3%–6% for all development types. The addition of this physically relevant representation of the deep-tropospheric state to the ingredients-based conceptual model for tropical cyclogenesis improves the representation of the important tropical transition-based subset of development events.
On the Dynamics of Flows Induced by Topographic Ridges
Authors: Chen Changheng , Kamenkovich Igor , Berloff Pavel 
Published: January 2015

AbstractThis study describes a nonlocal mechanism for the generation of oceanic alternating jets by topographic ridges. The dynamics of these jets is examined using a baroclinic quasigeostrophic model configured with an isolated meridional ridge. The zonal topographic slopes of the ridge lead to the formation of a system of currents, consisting of mesoscale eddies, meridional currents over the ridge, and multiple zonal jets in the far field. Dynamical analysis shows that transient eddies are vital in sustaining the deep meridional currents over the ridge, which in turn play a key role in the upper-layer potential vorticity (PV) balance. The zonal jets in the rest of the domain owe their existence to the eddy forcing over the ridge but are maintained by the local Reynolds and form stress eddy forcing. The analysis further shows that a broad stable current that either becomes locally nonzonal or encounters a topographic ridge tends to become unstable. This instability provides a vorticity source and generates multiple zonal jets in the far field through a nonlocal mechanism.
Evaluation of Humidity Correction Methods for Vaisala RS92 Tropical Sounding Data
Authors: Yu Hungjui , Ciesielski Paul E. , Wang Junhong , Kuo Hung-Chi , Vömel Holger , Dirksen Ruud 
Published: January 2015

AbstractThis study examines the DigiCORA and Global Climate Observing System Reference Upper-Air Network (GRUAN) humidity corrections of Vaisala RS92 radiosondes at three sites over the tropical Indian Ocean and surrounding areas during the Dynamics of the Madden–Julian Oscillation (DYNAMO) field campaign in 2011. The proprietary DigiCORA correction algorithm is built into the ground station software provided by Vaisala, whereas the GRUAN correction is an open source algorithm. Included in the GRUAN data product are uncertainty estimates for their corrections. This information is used to examine the statistical consistency of the various corrections.In general, the algorithms produce a positive relative humidity (RH) correction that increases with altitude related primarily to a solar radiation dry bias adjustment. For example, in daytime soundings the relative RH correction increases from a few percent for temperatures >0°C to 20%–40% between 100 and 200 hPa. Comparison of corrected RH vertical profiles show only small differences (on the order of a few percent or less at any given level) between the DigiCORA and GRUAN algorithms, such that these corrections are considered to be statistically consistent at most levels.In evaluating corrected humidity data with independent estimates of total precipitable water (TPW), good agreement was found at all sites between corrected sounding and ground-based microwave radiometer (MWR) estimates of TPW with mean differences ≤0.9 mm (or <2%), which is well within the uncertainty of these measurements. Overall, the correction algorithms examined herein perform well over a wide range of tropical moisture conditions.
A Real-Time Regional Forecasting System Established for the South China Sea and Its Performance in the Track Forecasts of Tropical Cyclones during 2011–13
Authors: Peng Shiqiu , Li Yineng , Gu Xiangqian , Chen Shumin , Wang Dongxiao , Wang Hui , Zhang Shuwen , Lv Weihua , Wang Chunzai , Liu Bei , Liu Duanling , Lai Zhijuan , Lai Wenfeng , Wang Shengan , Feng Yerong , Zhang Junfeng 
Published: January 2015

Abstract
A real-time regional forecasting system for the South China Sea (SCS), called the Experimental Platform of Marine Environment Forecasting (EPMEF), is introduced in this paper. EPMEF consists of a regional atmosphere model, a regional ocean model, and a wave model, and performs a real-time run four times a day. Output from the Global Forecast System (GFS) from the National Centers for Environmental Prediction (NCEP) is used as the initial and boundary conditions of two nested domains of the atmosphere model, which can exert a constraint on the development of small- and mesoscale atmospheric perturbations through dynamical downscaling. The forecasted winds at 10-m height from the atmosphere model are used to drive the ocean and wave models. As an initial evaluation, a census on the track predictions of 44 tropical cyclones (TCs) during 2011–13 indicates that the performance of EPMEF is very encouraging and comparable to those of other official agencies worldwide. In particular, EPMEF successfully predicted several abnormal typhoon tracks including the sharp recurving of Megi (2010) and the looping of Roke (2011). Further analysis reveals that the dynamically downscaled GFS forecasts from the most updated forecast cycle and the optimal combination of different microphysics and PBL schemes primarily contribute to the good performance of EPMEF in TC track forecasting. EPMEF, established primarily for research purposes with the potential to be implemented into operations, provides valuable information not only to the operational forecasters of local marine/meteorological agencies or international TC forecast centers, but also to other stakeholders such as the fishing industry and insurance companies.