bluuebunny/crossref_metadata_2025_split huggingface dataset:
Galleria mellonella infected with Bacillus thuringiensis involves Hsp90
Authors: Wojda Iwona , Kowalski Patryk 
Published: March 2013

Abstract
Insects are good models for studying the innate immune response. We report that Galleria mellonella larvae infected with entomopathogenic bacteria Bacillus thuringiensis kurstaki show changes in the level of Hsp90. Our experimental approach was to pre-treat larvae with the Hsp90-binding compound, 17-DMAG, before infection with B. thuringiensis. We show that pre-treated animals display a higher level of immune response. This was mainly manifested by enhanced action of their hemolymph directed toward living bacteria as well as lysozyme activity digesting bacterial peptidoglycan. The observed phenomenon was due to the higher activity of antimicrobial peptides which, in contrast to healthy animals, was detected in the hemolymph of the immunestimulated larvae. Finally, the physiological significance of our observation was highlighted by the fact that G. mellonella pre-treated with 17-DMAG showed a prolonged survival rate after infection with B. thuringiensis than the control animals. Our report points to a role for Hsp90 in the immune response of G. mellonella after infection with B. thuringiensis at the optimal growth temperature.
The composition and antibacterial activity of essential oils in three Ocimum species growing in Romania
Authors: Stefan Marius , Zamfirache Maria , Padurariu Claudia , Trută Elena , Gostin Irina 
Published: March 2013

Abstract
In this study the glandular hair morphology, chemical composition and antimicrobial activity of the essential oils from three Ocimum species have been investigated (Ocimum basilicum L. var. Genovese, O. gratissimum and O. tenuiflorum). The indumentum shows little variation among the investigated species with both glandular and non-glandular hairs presents. Glandular hairs on the three species are peltate and capitate (with various cell numbers in the stalk and gland). The samples of essential oils obtained from the plant aerial organs by hydrodistillation have been analyzed by GC-MS. Linalool (65.38%, 74.22%, 38.60%), eugenol (5.26%, 3.47%, 10.20%) and tau-cadinol (8.18%, 3.47%, 10.20%) appear as the main components in Ocimum basilicum L. var. Genovese, O. gratissimum and O. tenuiflorum. The oils also contain lower levels of α-bergamotene, 1,8-cineole, germacrene D, β-ocimene, α-caryophyllene, camphor, and α-guaiene. All essential oils showed antibacterial activity against Staphylococcus aureus and Escherichia coli depending on their concentration. Ocimum basilicum L. var. Genovese oil produced the strongest antibacterial effect on S. aureus and E. coli.
Natural contamination by As and heavy metals in soil, their bio-accumulation and potential sources: the case of a travertine limestone quarry, Greece
Authors: Kampouroglou Evdokia , Economou-Eliopoulos Maria 
Published: March 2013

AbstractThe first mineralogical and geochemical investigation of the travertine limestone, soil and corresponding plants associated with the Neogene basin of Varnavas, NE Attica, revealed a significant enrichment in the metalloid As. The total concentrations of As ranged from 61 to 210 ppm in limestone and 33 to 430 ppm in the associated soil demonstrating a wide variation of values. Calcite is a common authigenic mineral within travertine limestone, forming fine uniform micritic aggregates, having As and Mg concentrations lower than detection limits of EDS analysis. Clastic dominated minerals are quartz (both fine- and coarse-grained), muscovite, clinochlore, illite, pyrite, galena, arsenides, rutile, sphene, zircon, REE-minerals and albite. Goethite and Fe-Mn-oxides occur between calcite grains. The presence of fossilized micro organisms, resembling foraminifera, in travertine limestone combined with hydrous Fe-Mn-oxides, suggests a possible marine transgression during the evolution of the basin.The As content in plants ranges from 1.1 to 28 ppm As in shoots, and 0.8 to 114 ppm As in roots. The translocation factor, which is defined as the ratio of metal concentration in the shoots to the roots, is relatively low (average 0.33%) suggesting that the internal transport of metals from the roots to shoots was restricted. The bioaccumulation factor, which is defined as the ratio of metal concentration in the plants to that in soil, exhibits a wide range from relatively low (5.2–9.0% for As, Fe, Cr, Ni and Pb), much higher (56–67% for Cu and Zn) and exceptionally high (160% for Mo). A significant correlation between the translocation factors for Fe and As may confirm that Fe-Mn oxides/hydroxides represent the major sorbing agents for As in soils. The presented data, due to As contamination in travertine limestone, soil and plants, suggest a potential environmental risk not only for that part of Greece but in general for similar depositional environments.
Vitamin D in Cardiovascular and Renal Disease Prevention / Vitamin D u Prevenciji Kardiovaskularne i Bubrežne Bolesti
Authors: Pavlović Draško , Josipović Josipa , Pavlović Nikola 
Published: March 2013

Summary
Cardiovascular disease is a well-known public health problem. In the last ten years nephrologists have recognized chronic kidney disease not only as a public health problem but also as one of the major cardiovascular risk factors. There are observational data that support the concept that vitamin D is involved in the pathogenesis of cardiovascular and renal disease or that at least vitamin D deficiency is a risk factor for these diseases. In this brief review epidemiological data will be presented and the biological mechanism of the vitamin D effect on cardiovascular and renal disease will be discussed.
The Cost of Information in Dependence on the Investor Relation to the Risk
Authors: Hašková Simona 
Published: March 2013

Abstract
The contribution sets simple mathematic models describing and explaining the way of behavior of various types of investors (the private and institutionalized ones). The models come from the cardinal utility theory which is used for explaining the connection between the subjective relationship towards risk and some pathologic phenomenon of finance theory (for example the moral hazard question of institutionalized investors) and takes into account the decision making of both ordinary people and professional investors. A reliable estimate of the economic surroundings where the investment should run contributes significantly to a quality of the particular investment decisions. The article contributes to a quality of the investment decision by the original and primary approach to pricing information that lowers the uncertainty in occurrences of the relevant scenarios of the project’s development. At the conclusion there is shown how the shift of the decision breaking point shapes the amount of the acceptable price of the information.
The Impact of Polish-German Trade Flows on CO2 Emissions
Authors: Mizgajski Jan T. 
Published: March 2013

Abstract
This study analyses the embodied carbon in the trade flows between Poland and Germany. The calculations are based on data from Eurostat and OECD for 2008. The study uses input-output analysis, which allows the assignment of responsibility to individual flows for generating specific amounts of emissions in the economy. It demonstrates that Polish exports to Germany contain significantly more embodied carbon than do imports from Germany, despite the fact that the value of imports is higher. Moreover, it is found that Polish-German trade flows were responsible for more CO2 emissions that Lithuania and Latvia emitted together in 2008.
Impact of Eu Ets on Sustainable Development of its Participants in Latvia
Authors: Prūse Ilze 
Published: March 2013

Abstract
Latvia is covered by the European Union Emissions Trading System (EU ETS) and therein 80 participants from Latvia have participated. The goal of the paper is to analyse the impact of the EU ETS on the sustainable development of its participants in Latvia. The concept of sustainable development is explored with respect to both macro and micro scale and in the context of sustainable development the EU ETS is described. The impact of the EU ETS on its participants in Latvia is considered by means of methods of quantitative and qualitative analysis. It has been established that in past the participants of the EU ETS from Latvia had generally beneficial positions in the EU ETS; hence although the EU ETS did not directly promote greenhouse gas emission reductions, it provided opportunities to gain additional profits and many of the EU ETS participants in Latvia made use of them. In addition, certain interrelationships have been identified between the data on the EU ETS participants performing EUA trading and the data on the EU ETS participants not performing EUA trading. It has been concluded that the EU ETS might have contributed towards the sustainable development of its participants in Latvia within its certain dimensions.
Autologous conditioned plasma in anterior cruciate ligament reconstruction with hamstrings – short term clinical results
Authors: Russu O.M. , Gergely I. , Zazgyva Ancuța , Moldovan I. , Pop T.S. 
Published: March 2013

Abstract
Evaluating the early clinical results of anterior cruciate ligament reconstruction using hamstrings autograft, with interference screw on the tibial side (biocomposite interference screw, ConMed-Linvatec) and continuous closed loop fixation on the femoral side (XO-Button, ConMed-Linvatec), with and without intra-articular injection of autologous conditioned plasma (ACP). Our study included 21 patients with chronic anterior cruciate ligament (ACL) ruptures for whom we performed ACL reconstruction with a hamstrings autograft. The mean age was 34 years (range, 25 to 42), 16 patients were men and 5 were women. In 10 cases we performed an intraarticular infiltration of ACP at the end of the surgical intervention. Final evaluation was performed at the end of the 6th postoperative month using the Lysholm scoring system, Tegner activity scale and objective assessment with the RolimeterTM 50A. The Lysholm score was excellent in all cases at 6 months postoperatively, with a mean Lysholm score of 90 for patients without ACP and 91.09 for patients that received ACP; the mean Tegner activity score was also similar pre- and postoperatively for the two groups (from 3.5 and 3.63 for the group without ACP and the group with ACP to 5.6 and 5.72 respectively). Joint laxity measurement was similar for both groups. We found no graft ruptures. We found similar results after ACL reconstruction with and without intra-articular injection of PRP, but further studies are necessary to determine the exact role of these substances in speeding up the recovery process in these cases.
Spontaneous and therapeutic prognostic factors in adult hemispheric World Health Organization Grade II gliomas: a series of 1097 cases
Authors: Capelle Laurent , Fontaine Denys , Mandonnet Emmanuel , Taillandier Luc , Golmard Jean Louis , Bauchet Luc , Pallud Johan , Peruzzi Philippe , Baron Marie Hélène , Kujas Michèle , Guyotat Jacques , Guillevin Remi , Frenay Marc , Taillibert Sophie , Colin Philippe , Rigau Valérie , Vandenbos Fanny , Pinelli Catherine , Duffau Hugues , _ _ 
Published: March 2013

Object
The spontaneous prognostic factors and optimal therapeutic strategy for WHO Grade II gliomas (GIIGs) have yet to be unanimously defined. Specifically, the role of resection is still debated, most notably because the actual amount of resection has seldom been assessed.

Methods
Cases of GIIGs treated before December 2007 were extracted from a multicenter database retrospectively collected since January 1985 and prospectively collected since 1996. Inclusion criteria were a patient age ≥ 18 years at diagnosis, histological diagnosis of WHO GIIG, and MRI evaluation of tumor volume at diagnosis and after initial surgery. One thousand ninety-seven lesions were included in the analysis. The mean follow-up was 7.4 years since radiological diagnosis. Factors significant in a univariate analysis (with a p value ≤ 0.1) were included in the multivariate Cox proportional hazard regression model analysis.

Results
At the time of radiological diagnosis, independent spontaneous factors of a poor prognosis were an age ≥ 55 years, an impaired functional status, a tumor location in a nonfrontal area, and, most of all, a larger tumor size. When the study starting point was set at the time of first treatment, independent favorable prognostic factors were limited to a smaller tumor size, an epileptic symptomatology, and a greater extent of resection.

Conclusions
This large series with its volumetric assessment refines the prognostic value of previously stressed clinical and radiological parameters and highlights the importance of tumor size and location. The results support additional arguments in favor of the predominant role of resection, in accordance with recently reported experiences.
What is lacking in current decision aids on cancer screening?
Authors: Jimbo Masahito , Rana Gurpreet K. , Hawley Sarah , Holmes‐Rovner Margaret , Kelly‐Blake Karen , Nease Donald E. , Ruffin Mack T. 
Published: March 2013

AbstractRecent guidelines on cancer screening have provided not only more screening options but also conflicting recommendations. Thus, patients, with their clinicians' support, must decide whether to get screened, which modality to use, and how often to undergo screening. Decision aids could potentially lead to better shared decision‐making regarding screening between the patient and the clinician. A total of 73 decision aids concerning screening for breast, cervical, colorectal, and prostate cancers were reviewed. The goal of this review was to assess the effectiveness of such decision aids, examine areas in need of more research, and determine how the decision aids can be currently applied in the real‐world setting. Most studies used sound study designs. Significant variation existed in the setting, theoretical framework, and measured outcomes. Just over one‐third of the decision aids included an explicit values clarification. Other than knowledge, little consistency was noted with regard to which patient attributes were measured as outcomes. Few studies actually measured shared decision‐making. Little information was available regarding the feasibility and outcomes of integrating decision aids into practice. In this review, the implications for future research, as well as what clinicians can do now to incorporate decision aids into their practice, are discussed. CA Cancer J Clin 2013. © 2013 American Cancer Society.
Clinical efficacy of autogenous cancellous bone and fibroblast growth factor 2 combined with frozen allografts in femoral nonunion fractures
Authors: Ochi H. , Kannno N. , Iwata M. , Ichinohe T. , Harada Y. , Nezu Y. , Yogo T. , Tagawa M. , Hara Y. , Akagi H. 
Published: March 2013

SummaryObjectives: To evaluate the efficacy of cortical allograft and fibroblast growth factor 2 (FGF-2)-impregnated autogenous cancellous bone in nonunion fracture repair in dogs.Methods: From January 2000 to August 2010, seven dogs underwent cortical allograft and FGF-2-impregnated autogenous cancellous bone implantation for treatment of a femoral nonunion following fracture. Radiographic images were used to assess healing.Results: The average length of the implanted cortical allograft was 29.1 ± 4.4 mm. A significant improvement in the postoperative percentage of femoral shortening was observed with the experimental treatment, from 85.2 ± 8.2% to 95.0 ± 4.8%. Using radiographic scoring, we analysed the process of bone remodelling. At three months post-surgery, the proximal and distal fracture lines had begun to disappear, and a complete absence was observed after six months. Bacterial infection was detected in two of the seven cases.Clinical significance: The findings of our study suggest that the combination of cortical allografts with FGF-2 impregnated cancellous autograft may be useful in cases of diaphyseal fracture non-union. The disappearance of the fracture line in dogs with nonunion was recognized at the same phase as the report in which healing process of allograft was evaluated in the experimental ostectomy model using the normal dog.
Osteonecrosis of the Jaw and Nonmalignant Disease: Is There an Association with Rheumatoid Arthritis?
Authors: Lescaille Géraldine , Coudert Amélie E. , Baaroun Vanessa , Javelot Marie-José , Cohen-Solal Martine , Berdal Ariane , Goudot Patrick , Azérad Jean , Ruhin Blandine , Descroix Vianney 
Published: March 2013

Objective.To review cases of bisphosphonate-related osteonecrosis of the jaw (BRONJ) occurring in association with benign disease and to describe and compare the clinical course and outcome for patients with BRONJ and rheumatoid arthritis (RA) or osteoporosis.Methods.We retrospectively reviewed observations of all patients referred for treatment and followup for BRONJ from January 2007 to December 2011. Only patients with malignant disease were excluded. Demographic data, medical history, maxillofacial findings, BRONJ treatment, and followup were reviewed for each case.Results.Over a 5-year period, we diagnosed 112 patients with BRONJ. Among these patients, 15 received bisphosphonate (BP) treatment for nonmalignant disease (mean age 65.7 ± 19.8 yrs, 80% women). Patients received BP for a variety of reasons: 8 (53%) to prevent osteoporosis in association with underlying RA; 6 (40%) to prevent idiopathic osteoporosis; and 1 (7%) to treat ankle algodystrophy. The mean oral BP exposure period was 48.4 months (median 36 mo). In 13 cases (86.6%), BRONJ was diagnosed following dental extraction. Of the 8 patients with RA, 5 (62.5%) were taking prednisone at the time of the discovery of BRONJ. Major surgery, sequestrectomy, or alveolectomy was performed in 9 patients (60%), all of whom healed within 3 to 36 months (mean 11.5 mo). Comparative analysis of all the variables showed no statistically significant differences between patients with RA and others.Conclusion.ONJ is a rare adverse effect of BP therapy, especially when administered orally. Within the limits of our study, we were unable to demonstrate a difference in BRONJ disease spectrum, clinical course, or outcome between patients with and those without RA.
Application and Modifications of Minimal Disease Activity Measures for Patients with Psoriatic Arthritis Treated with Adalimumab: Subanalyses of ADEPT
Authors: Mease Philip J. , Heckaman Michele , Kary Sonja , Kupper Hartmut 
Published: March 2013

Objective.This posthoc analysis evaluated the percentage of patients with psoriatic arthritis (PsA) who achieved minimal disease activity (MDA) and compared the results with a modified MDA substituting the physician global assessment (PGA) for the Psoriasis Activity and Severity Index (PASI) using data from the ADalimumab Effectiveness in Psoriatic Arthritis Trial (ADEPT; NCT00646386).Methods.Patients with active PsA were randomized to receive adalimumab 40 mg or placebo every other week for 24 weeks. MDA was defined as achieving ≥ 5 of the following criteria: tender joint count ≤ 1; swollen joint count ≤ 1; PASI ≤ 1 or body surface area ≤ 3%; patient pain score ≤ 15 [1–100 mm visual analog scale (VAS)]; patient global assessment (PGA) of disease activity ≤ 20 (1–100 mm VAS); Health Assessment Questionnaire ≤ 0.5; and tender entheseal points ≤ 1 (only heels assessed). For modification of the MDA, PASI ≤ 1 was substituted with PGA “Clear” as MDAPGA1 and PGA “Clear” or “Almost clear” as MDAPGA2.Results.Sixty-seven patients were treated with adalimumab and 69 with placebo. At Week 24, MDA, MDAPGA1, and MDAPGA2 were achieved by 39%, 37%, and 39%, respectively, of patients treated with adalimumab versus 7%, 5%, and 8% of patients on placebo (p < 0.001). Kappa coefficients indicated good agreement between PASI and PGA at Week 24.Conclusion.ADEPT results indicated that significantly more patients treated with adalimumab achieved MDA by Week 24 compared with placebo. Modification of the MDA by replacing PASI ≤ 1 with PGA assessments did not alter the results, which may improve feasibility of practical use of the index.
« Un emploi, sinon un revenu garanti et décent »
Authors: Cottin-Marx Simon , Bourdeau Vincent 
Published: March 2013

Dans le cadre du dossier sur le revenu d’existence, nous avons voulu questionner le Mouvement national des chômeurs et précaires (MNCP) sur sa position originale vis-à-vis de cet outil, son adaptation à la situation des chômeurs et des précaires. L’appropriation par le MNCP du « revenu d’existence » manifeste une fois de plus la malléabilité et la multiplicité des usages du revenu d’existence.
Le revenu universel : outil de lutte féministe ?
Authors: Ouardi Samira 
Published: March 2013

D’un point de vue féministe, et plus spécifiquement d’un point de vue féministe matérialiste, la revendication d’un revenu garanti, dissocié de l’emploi, qu’il s’agisse d’un « revenu universel », d’un « revenu d’existence » ou d’un « revenu de citoyenneté », pose autant de problèmes qu’elle ouvre de perspectives. Le travail tient une place aussi centrale que complexe dans l’histoire de la lutte des femmes pour leur émancipation.
Reconnaître le travail étudiant par le salaire ?
Authors: Porte Emmanuel 
Published: March 2013

« L’étudiant est un jeune travailleur intellectuel ». Cette affirmation, formulée par certains militants de l’UNEF dans l’immédiate après-guerre, questionne le statut des études au regard du salariat et invite à appréhender le droit au salaire autrement que comme la contrepartie d’un travail subordonné. Elle pose autant la question de la reconnaissance de la productivité - actuelle et à venir - de l’étudiant que celle de son rôle social dans l’élévation du niveau de connaissance et de qualification globale de la société. Éclairant les débats contemporains sur le dépassement du rapport actuel à l’emploi, le retour sur la revendication de l’allocation d’étude de cette époque, nous permet de questionner les frontières du salariat et les conditions sociales et politiques de son évolution.
Quels droits pour un plein accès à la citoyenneté ?
Authors: Cottin-Marx Simon , Mylondo Baptiste 
Published: March 2013

La controverse est portée à gauche : face à la dégradation des régulations du travail, la montée de la précarité, le revenu universel est-il une solution ? Le sociologue présente le « travail » comme le terrain des conquêtes sociales passées et à venir, mais aussi comme un élément central et nécessaire pour la réalisation de la dignité des individus. Sceptique face à la proposition de garantir l’autonomie des individus en déconnectant le revenu de l’emploi, Robert Castel propose une stratégie qu’il souhaite réaliste et collective, sur le terrain du travail, de conquête de nouveaux droits pour garantir un accès entier à la citoyenneté.
Activation de la protection sociale : un droit à revenu universel de type nouveau ?
Authors: Nicole-Drancourt Chantal 
Published: March 2013

La peur du paupérisme réactualise la question de la mise en place d’un revenu universel et alimente une critique sévère des dispositifs dits « activés » de la protection sociale. Ces dispositifs sont pourtant très innovants car ils permettent d’articuler emploi et protection sociale. Quelle est la place du revenu universel dans le paysage de ces dispositifs de protection ? Comment relier ce projet aux défis de reconnaissance des autres activités sociales ?