bluuebunny/crossref_metadata_2025_split huggingface dataset:
Posterior prolongation of the cartilaginous nasal septum: an under-utilised source of autologous graft material
Authors: Phillips P S , Harvey R J , Sacks R , Chin D , Marcells G N 
Published: October 2012

AbstractAim:To assess the clinical and radiological characteristics of the posterior prolongation of the cartilaginous nasal septum, an under-utilised source of autologous cartilage for nasal reconstruction.Materials and methods:Consecutive patients undergoing primary, external approach rhinoplasty were included. The septal cartilage was assessed intra-operatively prior to routine harvest. Cartilage use was recorded and post-operative cosmesis noted. Computed tomography scans from a separate patient group, with no septal surgery, were used to assess septal cartilage dimensions.Results:Of the 25 rhinoplasty patients studied, 24 had harvestable septal cartilage, with a posterior prolongation mean length ± standard deviation of 24.3 ± 8.40 mm, mean height of 4.33 ± 0.34 mm and mean width of 1.1 ± 0.35 mm. The mean post-operative cosmesis score was +2.41 ± 0.71 at a mean follow up of 45 ± 8.7 weeks. All 25 radiology patients had visible posterior prolongations on computed tomography (mean length, 18.1 ± 5.1 mm; mean height, 4.2 ± 1.1 mm; mean width 1.5 ± 0.63 mm).Conclusion:Harvesting of the posterior prolongation would increase by 25 per cent the cartilage area available for autologous grafts. Endoscopic guidance aids this process. Cartilage is most commonly used for overlay grafts, with good cosmesis. The posterior prolongation is demonstrated on computed tomography, although dimensions may be underestimated.
Bondage on Qing China's Northwestern Frontier
Authors: NEWBY L. J. 
Published: October 2012

AbstractDespite the extensive literature on global slavery and servitude, human bondage in Xinjiang (Eastern Turkestan) during the eighteenth and nineteenth centuries has been largely neglected. Here bondage did not discriminate between ethnic, racial or religious groups and fulfilled a wide range of social, economic, and political functions, reflecting both the region's geographical position at the edge of Central Asia and its political position—first as a dependency and then as a province of Qing China. This paper discusses the nature of the forms of bondage that emerged in this unique geopolitical setting and suggests that the emancipation of Xinjiang's ‘British’ slaves at the end of the nineteenth century and the gradual decline of bondage resulted from a convergence of local, regional, and global forces.
Theoretical Poverty in the Research on Chinese Civil Society
Authors: SALMENKARI TARU 
Published: October 2012

AbstractThis paper critiques current academic usage of the analytic category of ‘civil society’ in recent studies of contemporary China. The problem is not the lack of good empirical work (which abounds), but rather the way in which understandings of ‘civil society’ as applied to China have remained insulated from wider theoretical debates emerging from other parts of the world which have queried the productive utility of these understandings. Specifically, recent studies of China continue to define civil society through its alleged autonomy from the state. This definition has led to unsettling discrepancies between theory and empirical knowledge about Chinese society. Moreover, it has caused researchers to pay little attention to the equally complicated question of whether there are sufficient horizontal linkages among various social actors to constitute a civil society in China in the first place. This paper will argue that lessons learned from the rich civil society tradition and scholarship from other parts of the world may be adapted fruitfully to generate more meaningful and nuanced analyses of Chinese associations.
Tocqueville's Unfinished Manuscript on Ireland
Authors: Kries Douglas 
Published: October 2012

AbstractIn the summer of 1835, Alexis de Tocqueville visited Ireland. Within the travelogue that he kept while on his journey, there exists an incomplete manuscript in which Tocqueville uses the literary device of the tableau to attempt a general explanation of Ireland's political and religious problems. The present essay explains why this manuscript, whose uniqueness has not previously been recognized fully, must be separated from the rest of the Irish journals, studied in relation to other Tocquevillian tableaux, and scrutinized carefully for its teaching on religion and politics. The essay then attempts an interpretation of the manuscript, which Tocqueville titled A Catholic Priest and a Protestant Minister in Ireland, especially as it bears on the question of Christianity and politics in Democracy in America. It concludes by considering whether Tocqueville once considered revising A Catholic Priest for possible inclusion in Democracy in America and why Tocqueville eventually abandoned the manuscript.
Knowing God and Knowing About God: Martin Buber'sTwo Types of FaithRevisited
Authors: Moberly R. W. L. 
Published: October 2012

AbstractInitially I briefly expound Martin Buber'sTwo Types of Faithso as to clarify Buber's sharp contrast between Jewish faith (HebrewEmunah) and Christian belief (GreekPistis). I suggest that Buber's polarisation ofEmunah, a trust and existential engagement with God, over againstPistis, an intellectual acknowledgement which lacks immediacy with God, has certain resonances with Wilfred Cantwell Smith's distinguishing between ‘faith’ and ‘belief’ in his attempt to overcome the Enlightenment tendency to reduce religious faith to propositional belief. I also acknowledge that Buber's conceptually alert and religiously constructive engagement with the Bible in its own way embodies many of the concerns in the current attempts to bring Bible and theology together via ‘theological interpretation’ or ‘a canonical approach’. However, Buber's account of the Old Testament overlooks the presence of the idiom ‘to know that’ (Hebrewyada(ki), which points to the importance of cognitive content in relation to knowing Israel's God. I consider a number of narratives which feature the deuteronomic idiom ‘to know thatYhwhis God’ (or closely comparable formulations) – Elijah on Mount Carmel (1 Kings 18), Rahab (Joshua 2), Naaman (2 Kings 5) and David and Goliath (1 Samuel 17) – and consider the function of ‘knowing thatYhwhis God’ in each passage. By way of conclusion I reflect on the complementarity of ‘knowing God’ and ‘knowing about God’ and the problematic nature of tendencies, represented by Buber, to set these over against each other. I also suggest that there is fruitful work to be done through a comparative and synthetic biblical and theological study of the relationship between the Old Testament concern that people should ‘know thatYhwhis God’ and the New Testament concern that people should ‘believe that Jesus Christ is Lord’.
‘Schmallenberg virus’ – a novel orthobunyavirus emerging in Europe
Authors: BEER M. , CONRATHS F. J. , VAN DER POEL W. H. M. 
Published: October 2012

SUMMARYIn 2011, a novel orthobunyavirus of the Simbu serogroup, the Schmallenberg virus (SBV), was discovered using a metagenomic approach. SBV caused a large epidemic in Europe in ruminants. As with related viruses such as Akabane virus, it appears to be transmitted by biting midges. Transplacental infection often results in the birth of malformed calves, lambs and goat kids. In more than 5000 farms in Germany, The Netherlands, Belgium, France, UK, Italy, Spain, Luxembourg, Denmark and Switzerland acute infections of adult ruminants or malformed SBV-positive offspring were detected, and high seroprevalences were seen in adult ruminants in the core regions in The Netherlands, Germany and Belgium. The discovery of SBV, the spread of the epidemic, the role of vectors, the impact on livestock, public health issues, SBV diagnosis and measures taken are described in this review. Lessons to be learned from the Schmallenberg virus epidemic and the consequences for future outbreaks are discussed.
Adequacy of child anthropometric indicators for measuring nutritional stress at population level: a study from Niakhar, Senegal
Authors: Garenne Michel , Maire Bernard , Fontaine Olivier , Briend André 
Published: October 2012

AbstractObjectiveTo compare the responsiveness of different anthropometric indicators for measuring nutritional stress among children in developing countries.DesignGrowth was studied within 6-month intervals in a rural Senegalese community during one dry and two rainy (hungry) seasons. Responsiveness was defined as the change divided by the standard deviation of each anthropometric indicator. Contrast was defined as the difference in responsiveness between dry and rainy seasons.SettingThe study was conducted in Niakhar, a rural area of Senegal under demographic surveillance, with contrasted food and morbidity situations between rainy and dry seasons.SubjectsSome 5000 children under 5 years of age were monitored at 6-month intervals in 1983–1984. The present analysis was carried out on a sub-sample of children aged 6–23 months with complete measures, totalling 2803 children-intervals.ResultsIn both univariate and multivariate analysis, mid-upper arm circumference was found to be more responsive to nutritional stress than the commonly used weight-for-height Z-score (contrast = −0·64 for mid-upper arm circumference v. −0·53 for weight-for-height Z-score). Other discriminant indicators were: muscle circumference, weight-for-height, BMI and triceps skinfold. Height, head circumference and subscapular skinfold had no discriminating power for measuring the net effect of nutritional stress during the rainy season.ConclusionsThe use of mid-upper arm circumference for assessing nutritional stress in community surveys should be considered and preferred to other nutritional indicators. Strict standardization procedures for measuring mid-upper arm circumference are required for optimal use.
Three-Dimensional Morphology of Microdamage in Peri-Screw Bone: A Scanning Electron Microscopy of Methylmethacrylate Cast Replica
Authors: Wang Lei , Shao Jin , Ye Tingjun , Deng Lianfu , Qiu Shijing 
Published: October 2012

AbstractScrew implantation inevitably causes microdamage in surrounding bone. However, little is known about the detailed characteristics of microdamage in peri-screw bone. In this study, we developed a method to construct microdamage cast with methylmethacrylate (MMA) and observed the cast using scanning electron microscopy (SEM). In basic fuchsin stained bone sections observed by bright-field and fluorescence microscopy, diffuse damage, cross-hatched damage, and linear cracks were all presented in peri-screw bone. Using MMA casting/SEM method, we found numerous densely packed microcracks in the areas with diffuse damage. The osteocyte canaliculi and the microcracks consisting of diffuse damage had a similar diameter (or width), usually <0.5 μm, but their morphology was largely different. In the area with cross-hatched damage, the orientation of microcracks was similar to that in diffuse damage, but the number was significantly decreased. Many microcracks were thicker than 1 μm and associated with a rough surface. Large linear cracks (∼10 μm in diameter) occurred in different areas. Plenty of microcracks were present on the surface of some linear cracks. In conclusion, the MMA casting/SEM method can demonstrate the three-dimensional morphology of different types of microdamage, particularly the microcracks in diffuse damage, which are unable to be shown by light microscopy.
Consequences of a Fat Diet in the Distribution of Minerals within Pancreatic Tissues of Rats and Rabbits
Authors: Ynsa M. Dolores , Minquin Ren , Rajendran Reshmi , Pinheiro Teresa , Watt Frank 
Published: October 2012

AbstractThe effects of plasma lipid overload on pancreatic islet function and on mineral imbalance are issues under debate. However, the outcomes may be biased by the different metabolisms of different species. This prospective study evaluated whether a high fat diet intake changed the distribution of physiologically relevant elements within pancreatic endocrine and exocrine tissues of Sprague Dawley rats and New Zealand White rabbits. Nuclear microscopy techniques provided images of the specimen density and structure as well as the elemental distributions and quantification of P, S, Cl, K, Ca, Fe, and Zn using unstained cryosections of pancreas. Our results indicate that pancreatic islets in normal rats and rabbits had lower tissue density and higher Ca, Fe, and Zn content compared to exocrine tissue, and that rabbit islets exhibit the highest Zn content (3,300 μg/g in rabbits versus 510 μg/g in rats). Fat diet intake resulted in large deposits of fat in the pancreas, which modified the density contrast of tissues and also resulted in a twofold decrease of Ca and Zn concentrations in islets of both rats and rabbits. This result indicates that a fat diet leads to a reduction in essential trace element concentrations in pancreas, which in turn may hamper endocrine function.
Funding of pensions and economic growth: are they really related?
Authors: ZANDBERG EELCO , SPIERDIJK LAURA 
Published: October 2012

AbstractWe examine whether changes in the degree of pension funding affect economic growth. Our sample consists of 54 countries, Organization for Economic Co-operation and Development (OECD) as well as non-OECD, during 2001–10. We do not find any effect of changes in the degree of funding on growth in the short-run. For the long-run the evidence is mixed. Although a growth model with overlapping observations suggests that there is a positive effect of funding changes on economic growth, we find no effect in a simple cross-sectional model.
“All my saints are within me”: Expressions of end-of-life spirituality
Authors: Dobratz Marjorie C. 
Published: October 2012

AbstractObjective:With spirituality being one of the most important components of end-of-life (EOL) care, this study explored the oral responses of 44 dying persons who expressed spirituality.Method:Four identified spiritual themes: religious systems of beliefs and values, life meaning, purpose and connections with others, nonreligious systems of beliefs and values, and metaphysical or transcendental phenomena served as a framework for a content analysis of 91 spiritual references.Results:From the content analysis, eight interrelated and separate themes emerged. Although the highest number of responses centered on religious beliefs and values, nonreligious beliefs and values that included reason, dignity, mental discipline, and communion were expressed. The themes of life meaning, purpose, and connections with others also surfaced as important aspects of EOL spirituality.Significance of results:The findings support the need for hospice/palliative care professionals to approach spirituality from other than a Judeo-Christian viewpoint, help dying persons create meaning and purpose within the context of their lives, and assist them in their desire for connectedness to faith communities and other significant individuals in their lives.
Crystal structures of Cg1458 reveal a catalytic lid domain and a common catalytic mechanism for the FAH family
Authors: Ran Tingting , Gao Yanyan , Marsh May , Zhu Wenjun , Wang Meitian , Mao Xiang , Xu Langlai , Xu Dongqing , Wang Weiwu 
Published: October 2012

Cg1458 was recently characterized as a novel soluble oxaloacetate decarboxylase. However, sequence alignment identified that Cg1458 has no similarity with other oxaloacetate decarboxylases and instead belongs to the FAH (fumarylacetoacetate hydrolase) family. Differences in the function of Cg1458 and other FAH proteins may suggest a different catalytic mechanism. To help elucidate the catalytic mechanism of Cg1458, crystal structures of Cg1458 in both the open and closed conformations have been determined for the first time up to a resolution of 1.9 Å (1 Å=0.1 nm) and 2.0 Å respectively. Comparison of both structures and detailed biochemical studies confirmed the presence of a catalytic lid domain which is missing in the native enzyme structure. In this lid domain, a glutamic acid–histidine dyad was found to be critical in mediating enzymatic catalysis. On the basis of structural modelling and comparison, as well as large-scale sequence alignment studies, we further determined that the catalytic mechanism of Cg1458 is actually through a glutamic acid–histidine–water triad, and this catalytic triad is common among FAH family proteins that catalyse the cleavage of the C–C bond of the substrate. Two sequence motifs, HxxE and Hxx…xxE have been identified as the basis for this mechanism.
Exploring inhibition of Pdx1, a component of the PLP synthase complex of the human malaria parasite Plasmodium falciparum
Authors: Reeksting Shaun B. , Müller Ingrid B. , Burger Pieter B. , Burgos Emmanuel S. , Salmon Laurent , Louw Abraham I. , Birkholtz Lyn-Marie , Wrenger Carsten 
Published: October 2012

Malaria tropica is a devastating infectious disease caused by Plasmodium falciparum. This parasite synthesizes vitamin B6de novo via the PLP (pyridoxal 5′-phosphate) synthase enzymatic complex consisting of PfPdx1 and PfPdx2 proteins. Biosynthesis of PLP is largely performed by PfPdx1, ammonia provided by PfPdx2 subunits is condensed together with R5P (D-ribose 5-phosphate) and G3P (DL-glyceraldehyde 3-phosphate). PfPdx1 accommodates both the R5P and G3P substrates and intricately co-ordinates the reaction mechanism, which is composed of a series of imine bond formations, leading to the production of PLP. We demonstrate that E4P (D-erythrose 4-phosphate) inhibits PfPdx1 in a dose-dependent manner. We propose that the acyclic phospho-sugar E4P, with a C1 aldehyde group similar to acyclic R5P, could interfere with R5P imine bond formations in the PfPdx1 reaction mechanism. Molecular docking and subsequent screening identified the E4P hydrazide analogue 4PEHz (4-phospho-D-erythronhydrazide), which selectively inhibited PfPdx1 with an IC50 of 43 μM. PfPdx1 contained in the heteromeric PLP synthase complex was shown to be more sensitive to 4PEHz and was inhibited with an IC50 of 16 μM. Moreover, the compound had an IC50 value of 10 μM against cultured P. falciparum intraerythrocytic parasites. To analyse further the selectivity of 4PEHz, transgenic cell lines overexpressing PfPdx1 and PfPdx2 showed that additional copies of the protein complex conferred protection against 4PEHz, indicating that the PLP synthase is directly affected by 4PEHz in vivo. These PfPdx1 inhibitors represent novel lead scaffolds which are capable of targeting PLP biosynthesis, and we propose this as a viable strategy for the development of new therapeutics against malaria.
Insulin‐regulated expression of adiponectin receptors in muscle and fat cells
Authors: Sattar Akm A. , Sattar Rifat 
Published: October 2012

AbstractAdp (adiponectin), an adipocyte‐secreted hormone, exerts its effect via its specific receptors, AdipoR1 and AdipoR2 (adiponectin receptors 1 and 2), on insulin‐sensitive cells in muscle, liver and adipose tissues, and plays an important role in lipid and glucose metabolisms. The study has investigated the effect of insulin on AdipoRs expression in muscle and fat cells. Differentiated fat [3T3‐L1 (mouse adipocytes)], L6 (skeletal muscle) and vascular smooth muscle (PAC1) cells were serum starved and exposed to 100 nM insulin for 1–24 h. AdipoR1 and AdipoR2 mRNAs expression was monitored by real‐time PCR. The results demonstrate that insulin down‐regulates both AdipoR1 and AdipoR2 mRNAs levels in a biphasic manner in L6 and PAC1 cells. Insulin had little or no effect in the regulation of AdipoR1 expression in 3T3‐L1 cells, but significantly up‐regulated AdipoR2 mRNA level in a biphasic manner. The fact that insulin differentially regulates the expression of AdipoR1 and AdipoR2 in muscle and fat cells suggests this is also dependent on the availability of the endogenous ligand, such as Adp for AdipoR1 and AdipoR2 in fat cells. The effects of globular Adp were also tested on insulin‐regulated expression of AdipoRs in L6 cells, and found to up‐regulate and counter insulin‐mediated suppression of AdipoRs expression in L6 cells.
Does uric acid qualify as an independent risk factor for cardiovascular mortality?
Authors: Jeemon Panniyammakal , Prabhakaran Dorairaj 
Published: October 2012

UA (uric acid) is the final product of purine metabolism in humans and is implicated in many disease conditions. Sustained hyperuricaemia has putative adverse roles in cardiovascular diseases. Despite strong evidence emerging from large epidemiological studies supporting the hypothesis that UA independently influences cardiovascular disease outcomes and mortality, a causal role is yet to be established. Serum UA is also considered as a useful biomarker for mortality in high-risk patients with acute coronary syndromes, heart failure and hypertension and in patients with Type 2 diabetes mellitus. Post-hoc analyses of clinical trial data suggest beneficial effects of reducing serum UA. However, these findings are inconclusive and are only hypothesis-generating. In the present issue of Clinical Science, Ndrepepa and co-workers have investigated the prognostic role of UA in high-risk Type 2 diabetic patients with established coronary artery disease in predicting 1-year survival and cardiovascular mortality. These results support the independent role of serum UA in predicting survival in Type 2 diabetic patients. However, long-term follow-up studies are required with serial UA measurement to establish the time-dependent association of UA with mortality outcomes.
Progress in Understanding Adolescent Language Disorders
Authors: Joffe Victoria L. , Nippold Marilyn A. 
Published: October 2012

Purpose
This prologue introduces a clinical forum on adolescent language disorders, a topic that has long been of interest to school-based speech-language pathologists/therapists.

Method
A rationale for the clinical forum is provided, and the content is contrasted with a previous forum on the same topic that was published nearly 20 years ago. Implications and directions for future research and practice in adolescent language disorders are discussed.

Conclusions
Considerable progress has occurred in our understanding of the nature, assessment, and treatment of language and communication disorders in adolescents and young adults. Yet we continue to need to build the evidence base on the most effective and efficient ways of enhancing the spoken and written language skills of young people with language and communication disorders in academic, social, emotional, and vocational domains.