bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgical outcomes of unilateral medial rectus recession for partially accommodative esotropia
Authors: Hwang Jeong-Min , Yang Hee Kyung , Lee Donghun 
Published: July 2024

Abstract

We investigated the long-term outcomes of unilateral medial rectus (UMR) recession surgery inpartially accommodative esotropia (PAET). Children aged ≤ 10 years with PAET who had residual esotropia of ≤ 25 prism diopters (PD) after full hypermetropic correction and underwent UMR recession were included. Medical records of patients who were followed up for at least 1 year postoperatively were retrospectively reviewed. Successful outcome was defined as phoria of ≤ 5 PD. Total of 28 patients were included. The preoperative esodeviation at distance fixation was 15.5 ± 3.7 PD (range, 10–25 PD). The mean dose of UMR recession was 5.64 ± 0.68 mm (range, 4.0–7.0 mm). The average postoperative follow-up time was 4.4 ± 3.1 years. At the last examination, esodeviation significantly decreased to 6.2 ± 13.8 PD and the surgical success rate was 53.6%. In the success group, the age at surgery was older (P = 0.005), the duration of wearing prism glasses was longer (P = 0.030), and the amount of UMR recession was greater (P < 0.001) than in the failure group. Only half of the patients with small to moderate angle PAET achieved successful long-term outcomes through UMR recession. Having sufficient time to wear prism glasses before surgery to achieve good binocularity and receiving a sufficient amount of surgical correction may improve surgical success.
A Privacy Preservation Model for Dynamic Trajectory Datasets
Authors: Riyana Surapon 
Published: July 2024

Abstract

Trajectory datasets are proposed to collect the visited location path of users and their visited times.They are generally used in location-awareness applications.Aside from these applications, they are often released to the data analyst with a suitable business reason.Although they are more beneficial, they have several issues that must be considered when they are utilized, e.g., data privacy and data utility.To achieve data privacy and data utility in trajectory datasets, a well-known privacy preservation model, LKC-Privacy, was proposed. That is, before trajectory datasets are utilized, the at most L-size of unique subsequent paths are suppressed to be at least K indistinguishable tuples.Moreover, the protected sensitive values relate to each group of indistinguishable subsequent paths, they must have the confidence of data re-identification to be at most C. Thus, the trajectory datasets are satisfied by LKC-Privacy constraints, they can guarantee that all at most $L$-size of subsequent paths always have at least K - 1 duplicate tuples and every protected sensitive value has the confidence of successful re-identification to be at most C.However, LKC-Privacy is proposed to address privacy violation issues in trajectory datasets that are focused on performing one-time data releases.To the best of our knowledge about trajectory datasets, some trajectory datasets are dynamic, i.e., they allow change when new data is available.Thus, LKC-Privacy could be insufficient to address privacy violation issues in these trajectory datasets.To rid this vulnerability of LKC-Privacy, a new LKC-Privacy is proposed in this work.Moreover, the proposed model is evaluated by extensive experiments. From the experimental results, they show that the proposed privacy preservation model is more effective than LKC-Privacy.
Serum assisted PD-L1 aptamer screening for improving its stability
Authors: Zhou Yu , Zhang Haozhe , Ding Yujing , Yu Changyuan , Li Hao 
Published: July 2024

Abstract

Aptamers have shown potential for diagnosing clinical markers and targeted treatment of diseases. However, their limited stability and short half-life hinder their broader applications. Here, a real sample assisted capture-SELEX strategy is proposed to enhance the aptamer stability, using the selection of specific aptamer towards PD-L1 as an example. Through this developed selection strategy, the aptamer Apt-S1 with higher binding affinity and specificity towards PD-L1 was obtained as compared to the aptamer Apt-A2 which was screened by the traditional capture-SELEX strategy. Moreover, Apt-S1 exhibited a greater PD-L1 binding associated conformational change than Apt-A2, indicating its suitability as a biorecognition element. These findings highlight the potential of Apt-S1 in clinical applications requiring robust and specific targeting of PD-L1. Significantly, Apt-S1 exhibited a lower degradation rate in 10% diluted serum or pure human serum, under the physiological temperature and pH value, compared to Apt-A2. This observation suggested that Apt-S1 possesses higher stability and is more resistant to damage caused by the serum environmental factors, highlighting the superior stability of Apt-S1 over Apt-A2. Furthermore, defatted and deproteinized serum were used to investigate the potential reasons for the improved stability of Apt-S1. The results hinted that the pre-adaptation to nucleases present in serum during the selection process might have contributed to its higher stability. With its improved stability, higher affinity and specificity, Apt-S1 holds great potential for applications in PD-L1 assisted cancer diagnosis and treatment. Meanwhile, the results obtained in this work provide further evidence of the advantages of the real capture-SELEX strategy in improving aptamer stability compared to the traditional strategy.
ChronoBridge: A Novel Framework for Enhanced Temporal and Relational Reasoning in Temporal Knowledge Graphs
Authors: Liu Qian , Feng Siling , Huang MengXing , Bhatti Uzair Aslam 
Published: July 2024

Abstract

The prediction task of entities and relationships in Temporal Knowledge Graph (TKG) extrapolation is crucial and extensively studied. Mainstream algorithms like Gated Recurrent Unit (GRU) models primarily focus on encoding historical factual features within TKGs, often neglecting the importance of incorporating entity and relationship features during decoding. This bias ultimately leads to loss of detail and inadequate prediction accuracy during the inference process .Addressing this issue, a novel ChronoBridge framework is proposed, featuring a dual mechanism of a Chronological node Encoder and a Bridged Feature Fusion Decoder. Specifically, the Temporal Node Encoder employs an advanced recursive neural network with enhanced GRU in an autoregressive manner to model historical KG sequences, thereby accurately capturing entity changes over time and significantly enhancing the model’s ability to identify and encode temporal patterns of facts across the timeline. Meanwhile, the Bridge Feature Fusion Decoder utilizes a new variant of GRU and a multi-layer perceptron mechanism during the prediction phase to extract entity and relationship features and fuse them for inference, thereby strengthening the model’s reasoning capabilities for future events.Test results on three standard datasets demonstrate significant performance improvements compared to existing techniques, with a 25.21% increase in Mean Reciprocal Rank (MRR) accuracy for prediction tasks and a 39.38% improvement in relationship inference, thus validating its effectiveness. This breakthrough not only enhances understanding of temporal evolution in knowledge graphs but also paves the way for future research and applications in TKG reasoning.
Digitalisation and Green Strategies: A systematic review of the Textile, Apparel and Fashion Industries
Authors: Orisadare Emmanuel Ayo , Achukwu Okechukwu Emmanuel , Ogunyemi Abiodun Afolayan , Adedeji Deborah Oluwayemisi , Diyaolu Idowu Jamiu , Ugwu Eunice Ifenyinwa , Oluwatope Ayodeji Oludola , Bakare Kudirat Oyebisi , Awoyelu Iyabo Olukemi 
Published: July 2024

Abstract

The Textile, Apparel, and Fashion (TAF) industries significantly contribute to national gross domestic products but also account for 20% of global pollution. The Industry 4.0 (I 4.0) framework, incorporating technologies like the Internet of Things (IoT), Artificial Intelligence, and robotics, enables smart and efficient manufacturing production, leading to more significant economic outputs. However, it also brings about issues like automation-related tensions, energy efficiency, and waste management and other sustainable practice demands. The Industry 5.0 (I 5.0) framework addresses the issues created by Industry 4.0 in many areas, especially promoting human-centric sustainable practices, social interaction, and a proper synergy between man and machine. This article examined the issues closely based on a systematic review of 42 peer-reviewed studies from 2013 to 2023 exploring the dynamics between technological advancements and sustainable practices in the TAF industries. The review identified technological implementations, circular economy support, and challenges associated with implementing the I 4.0 and 5.0 frameworks. The article analyses significant research using a descriptive literature review to understand the strategies, impact, and challenges of digitalisation and green transition in TAF industries' production and sustainability. The findings reveal a big dichotomy between the Global North and Global South TAF firms, indicating a more contextualised approach is required to integrate I 4.0 and 5.0 approaches and promote sustainable production practices. This study offers a synthesised overview of the current landscape, providing insights for stakeholders, policymakers, and researchers engaged in navigating the TAF industries towards a sustainable, digitally advanced, circular economy future.
Formation of productivity elements of winter wheat varieties depending on agrotechnical factors in the conditions of the central Forest-­Steppe
Authors: Demydov O. A. , Dubovyk N. S. , Kyrylenko V. V. , Gumeniuk O. V. , Siroshtan A. A. , Sabadyn V. Y. , Kumanska Yu. O. , Los R. M. , Vlasenko I. S. , Lashuk S. O. 
Published: July 2024

Purpose. To determine the elements of productivity of new winter wheat varieties of the Myronivka breeding in the conditions of the central Ukrainian Forest­Steppe, depending on the predecessors and sowing dates. Methods. The research was conducted in 2019–2021 in a four­factor experiment on the fields of the V. M. Remeslo Myronivka Institute of Wheat of NAAS (MIW), located in the central part of the Ukrainian Forest­Steppe. The subject of the research was the processes of productivity formation of soft winter wheat; five new varieties of Myronivka breeding (‘MIP Fortuna’, ‘MIP Lada’, ‘MIP Yuvileina’, ‘Avrora Myronivska’, ‘MIP Lakomka’) were compared with the standard (‘Podolianka’). The trials were designed according to two predecessors – the common sunflower and soybean; sowing was carried out on 25 September and 5 October with a deviation of 1–3 days. Results. According to the results of the research, the optimal growth and development of the plants of the soft winter wheat varieties in the corresponding phenological phases, as well as the formation of the ear during the gro­wing season were ensured. The best vegetation period was in 2019, when the length of the central ear was more than 10.00 cm. Taking into account the influence of the sowing date after predecessors such as the common sunflower and soybean, the varieties ‘MIP Lada’ and ‘MIW Fortuna’ proved to be stable in terms of central spike length, providing high plant productivity. An important element of the latter is the number of grains in the spike, which was highest in ‘Avrora Myronivska’ (61 pcs) in 2021 at the second sowing date. Grain weight values from the central ear also depended on variety, sowing date and predecessor. A direct correlation between the studied productivity indicators and yield was found. Conclusions. Following an analysis of the indicators of productivity formation, three valuable winter wheat varie­ties were identified as being suitable for cultivation in the Central Forest­Steppe of Ukraine. These are ‘MIP Fortuna’, ‘MIW Lada’ and ‘MIW Lakomka’.
A Pharmacological Update of Triazole Derivative: A Review
Authors: Parthasarathi Venkatesan , Kanagaraj Hemalatha 
Published: July 2024

:
Recently, a large number of novel heterocyclic compounds and their derivatives have been synthesized, and studies on their biological functions have been conducted. Even though the triazole moiety of this scaffold appears to be fairly small, many researchers are interested in it be-cause of its biological profile and variety of potential uses. Triazole derivatives have been synthe-sized and published by various researchers as their important characteristic against various dis-eases. Several researchers are interested in this scaffold because of its biological profile and wide variety of potential uses, even if its triazole moiety seems to be somewhat less. The derivative of this heterocyclic ring produced various biological activities such as anti-inflammatory, anticon-vulsant, hypoglycemic, antitubercular, anxiolytic, antimicrobial, antitumor, and anticancer. The current review article focuses on pharmacological profile associated with triazoles and mainly fo-cuses on structural modification done for various targets, along with a brief description of targets.
Immunologic Mechanisms of BCc1 Nanomedicine Synthesized by Nanochelating Technology in Breast Tumor-bearing Mice: Immunomodulation and Tumor Suppression
Authors: Karimi Pegah , Fakharzadeh Saideh , Kalanaky Somayeh , Hafizi Maryam , Hashemi Mehrdad , Mahdavi Mehdi , Nazaran Mohammad Hassan 
Published: July 2024

Introduction:
The side effects of anti-cancer chemotherapy remain a concern for patients. So, designing
alternative medications seems inevitable. In this research, the immunological mechanisms of BCc1 nanomedicine
on tumor-bearing mice were investigated.

Methods:
BALB/c mice underwent tumor transplantation and were assigned into four groups. Group 1 was orally
administered with PBS buffer, Group 2 was orally administered BCc1 10 mg/kg, and Group 3 was orally administered
BCc1 40 mg/kg daily, respectively. In addition, a group of mice was administered Cyclophosphamide, 20
mg/kg daily. The weight and tumor volume of mice were evaluated bi-weekly. After 24 days of treatment, cytokines
and CTL assay in the spleen cell and the tumor were assessed. Furthermore, the spleen, liver, kidney, lung,
gut, and uterine tissue were stained with hematoxylin and eosin. Finally, the tumor samples were stained and
analyzed for FOXP3. The survival rate of mice was recorded.

Results:
The results confirmed the histological safety of BCc1. This nanomedicine, especially BCc1 10 mg/kg,
led to a strong IFN-γ response and suppressed TGF-β cytokine. The frequency of Treg in the tumor tissue of
BCc1 nanomedicine groups was decreased. In addition, nanomedicine repressed tumor volume and tumor weight
significantly, which was comparable to Cyclophosphamide. These immunologic events increased the survival rate
of BCc1-treated groups. The results indicate that BCc1 nanomedicine can suppress tumor growth and thereby
increase the survival rate of experimental mice.

Conclusion:
It seems a modulation in the tumor microenvironment and polarization toward a Th1 response may
be involved. So, BCc1 nanomedicine is efficient for human cancer therapy.
An Efficient Hybrid Spoofing/Spot-jamming Strategy on Unmanned
Aerial Vehicles
Authors: Ballouk Abdo , Chahine Mohamed Khaled , Alhariri Mohamed 
Published: July 2024

Background:
Unmanned Aerial Vehicles (UAVs) pose significant security risks to critical
infrastructures, potentially leading to accidents, attacks, or illicit surveillance. Robust prevention
measures are essential around strategic facilities. The navigation and control of UAV systems fundamentally
depend on the Global Positioning System (GPS). Consequently, jamming or spoofing
the GPS navigation system can significantly hinder the control and direct UAVs to their specified
destinations. This paper introduces a novel hybrid spoofing/spot jamming system aimed at fortifying
security against UAV threats.

Objective:
This study aims to propose and evaluate the efficiency of a hybrid spoofing/spotjamming
system to bolster security against UAVs.

Methods:
Leveraging a Software-Defined Radio (SDR) and complementary software tools, we
generated spoofing and jamming signals targeting the civilian-use signals of GPS satellites at the L1
frequency (1575.42 MHz), incorporating the Coarse Acquisition (C/A) code. The system enables
flexible timing adjustments within the navigation message to simulate fictitious locations.

Results:
Through comprehensive testing involving multiple commercial UAVs across three distinct
scenarios—reactive spoofing, proactive spoofing, and spot jamming followed by spoofing—the experiments
demonstrated superior efficacy in proactive spoofing and spot jamming followed by GPS
spoofing, compared to reactive spoofing alone.

Conclusion:
Proactive spoofing and spot jamming, followed by GPS spoofing, emerge as more effective
strategies for countering UAV threats, offering enhanced security measures for critical infrastructures
vulnerable to UAV intrusions. This hybrid approach holds promise in augmenting existing
defense mechanisms against evolving UAV-based security risks.
Chemical Composition and Antiparasitic Effects of Prangos ferulacea (L.) Lindl., Essential Oil against Echinococcus granulosus Protoscoleces
Authors: Abidi Hassan , Bakhtiari Mohammadreza , Zoladl Mohammad , Mansourkhani Hossein Sadeghi , Razmjoue Damoun , Bahmani Mahmoud 
Published: July 2024

Introduction:
Hydatidosis is an infectious disease that occurs in the larval stage of
Echinococcus granulosus. Benzimidazoles are the only official and approved drugs for treatment, but their effectiveness varies among patients. Therefore, safe discoveries are needed for
new and safe herbal medicines and supplements to improve the treatment of this disease. The
current research was carried out to investigate the chemical composition of the plant essential
oil and its protoscolicidal effects on hydatid cyst protoscolex in laboratory conditions.

Methods:
Gas chromatography/mass spectrometry (GC/MS) analysis was performed to identify
the chemical composition of the essential oil EO(s). Hydatid cyst protoscoleces were collected
from infected sheep's liver and then treated with concentrations of EO(s) (0.625, 1.25, 2.5, 5 and
10 mg/mL) for 3, 5, 10, 15, and 30 minutes in laboratory conditions. Then, using eosin dye, the
viability of protoscolexes was examined.

Results:
According to GC/MS analyses, the main components of the EO(s) were β-Pinene
(27.01%), (+)-3-Carene (24.87%), α-Pinene (18.34%), and Sabinene (17.69%), respectively.
The killing effects of 5 and 10 minutes of exposure to 2.5 mg/ml of this essential oil were 100%
lethal. Statistical results showed that the best time was 5 minutes, with a concentration of 5
mg/mL as the lowest concentration and the shortest incubation time (P<0.05).

Conclusion:
Our findings show the strong protoscolide effects of P. ferulacea plant essential oil
in vitro. However, more studies are needed to assess the safety and efficacy of this plant as a
promising anti-inflammatory agent in vivo and clinical studies
Periodontal Tissue Homoeostasis, Immunity, the Red Complex Pathogens, and Dysbiosis: Unraveling the microRNA Effect
Authors: Mishra Swastik , Puzhankara Lakshmi 
Published: July 2024

:
microRNAs are a family of small, non-coding RNA molecules that can regulate the
translation of messenger RNAs (mRNAs). Numerous miRNAs have been proposed as potential
indicators for periodontal disease, and their regulation might serve as a potent means of restricting
the disease process.

:
MiRNAs act as important immune system regulators that promote the production of many cytokines,
including interferon (IFN), tumour necrosis factor (TNF), and IL-1as well as RANK. Investigations
pertaining to the use of specific miRNAs as therapeutic agents are underway. They
can influence a variety of regulatory organs and target several genes. Additionally, distinct components
of the same expression pathway can be controlled by combining miRNAs and their antagonists.
In recent years, many miRNA delivery methods have been created for therapeutic applications.

:
Studies pertaining to the role of miRNAs in periodontal disease pathogenesis may pave the way
for the use of miRNAs as biomarkers of periodontal disease. A complete understanding of the
role of miRNA in periodontal disease and its mechanism of action can pave the way towards
therapeutic strategies that can reduce or even prevent the progression of periodontal diseases.
Role of Ahara-Vihara and Rasayana in prevention of disease and maintenance of health
Authors: Ravindra Narayan  , Bhumika Bhardwaj  , Harshika Bhardwaj  
Published: July 2024

Ahara and Vihara play very important role in getting these Prayojana. The crucial role of Ahara and Vihara is maintenance of Dhatus i.e., Dhatusamya, by which all physiological activity remain proper e.g. Dahana, Pachana, Chaya-Upachaya Kriya, etc. By Vihara the fitness and constitutional arrangement of body remain well, Jatharagni gets improved and Bala as well Vyadhikshamatva also gets improved. Acharya Charaka says “Aharah Praninam Pranah” and Acharya Sushruta says “Praninam Punarmoolam Aharo Balavarna Ojasam Cha” that is the Ahara is the life of all the Pranis as well as base of Bala, Varna and Oja i.e., life is impossible without Ahara. Thus, Ahara and Vihara are useful for prevention of diseases. Ayurveda also frequently referred as 'Ashtanga Ayurveda' and Rasayana Chikitsa are the part of the Ashtanga Ayurveda. It helps a person to maintain good health or to establish impaired or lost physical or mental health. Rasayana Chikitsa are said to revitalize all the Sapta Dhatus (body elements), therefore, restores equilibrium and health.
ID pemeran utama dalam cerita bersambung kembang Alas Jati majalah Djaka Lodang
Authors: Ripski Ripskiaji , Widayat Afendy 
Published: July 2024

Manusia memiliki kecenderungan, dan manusia memiliki ciri yang mampu dilihat menggunakan mata, juga ada ciri manusia yang dapat dilihat dari perlilaku manusia itu sendiri. Perilaku manusia dapat mecerminkan siapa dirinya, dapat dilihat dengan aspek yang disebut dengan kejiwaan. Kejiwaan yang ada pada dalam diri seorang tokoh juga menarik untuk diteliti, penelitian mengenai kejiwaan tokoh dalam sebuah karya sastra disebuh dengan kajian psikologis sastra. Tujuan dari penelitian ini mengkaji mengenai id,yang ada dalam diri pemeran tokoh utama pada cerita bersambung Kembang Alas Jati dalam majalah Djaka Lodang. Metode yang digunakan dalam penelitian ini adalah menggunakan metode kualitatif untuk menelaah kajian pada teks, kemudian pada penelitian ini menggunakan penyampaian dengan mendeskriptifkan suatu temuan, sekaligus digunakan untuk menjelaskan suatu masalah. Konflik dalam diri pemeran utama menghasilkan id yang berupa respon secara spontan dalam menghadapi suatu masalah. Penelitian id pemeran utama cerita bersambung Kembang Alas Jati majalah Djaka Lodang ini ditemukan beberapa hasil seperti takut, tidak perduli, bingung, bahagia, curiga, tabjuk, dan sendih.Kata Kunci: Cerita Bersambung, Kembang Alas Jati, Id, Psikologis sastra.