bluuebunny/crossref_metadata_2025_split huggingface dataset:
Representative mammalian cell culture test materials for assessment of primary recovery technologies: A rapid method with industrial applicability
Authors: Popova Daria , Stonier Adam , Pain David , Titchener‐Hooker Nigel J. , Farid Suzanne S. 
Published: November 2014

AbstractMammalian cell culture material is often difficult to produce accurately and reproducibly for downstream studies. This article presents a methodology for the creation of a set of cell culture test materials where key variables including cell density, cell viability, product, and the host cell protein (HCP) load can be manipulated individually. The methodology was developed using a glutamine synthetase Chinese hamster ovary cell line cultured at 5‐L and 70‐L scales. Cell concentration post‐cell growth was manipulated using tangential flow filtration to generate a range of target cell densities of up to 100 × 106 cells/mL. A method to prepare an apoptotic cell stock to achieve target viabilities of 40–90% is also described. In addition, a range of IgG1 and HCP concentrations was achieved. The results illustrate that the proposed methodology is able to mimic different cell culture profiles by decoupling the control of the key variables. The cell culture test materials were shown to be representative of typical cell culture feed material in terms of particle size distribution and HCP population. This provides a rapid method to create the required feeds for assessing the feasibility of primary recovery technologies designed to cope with higher cell density cultures.
ChemInform Abstract: A Structural Comparison of Two Thallium Copper Erbium Sulfides: TlCu3Er2S5 and Tl2Cu5Er3S8.
Authors: Eberle Marcel A. , Babo Jean‐Marie , Schleid Thomas 
Published: November 2014

AbstractOrange TlCu3Er2S5 (I) is prepared by solid state reaction of a 2:1:3 molar mixture of Cu, Er, and S to which an excess TlCl is given as a flux (evacuated silica tubes, 850 °C, 8 d).
ChemInform Abstract: Sulfur as a Selectivity Modifier in a Highly Active Rh/Fe2O3/ZrO2 Catalyst for Water‐Gas Shift.
Authors: Hakeem Abrar A. , Rajendran Jaikishen , Kapteijn Freek , Makkee Michiel Makkee Michiel 
Published: November 2014

AbstractThe water‐gas shift selectivity and stability of a Rh/Fe2O3/ZrO2 catalyst under typical industrial conditions is improved by the presence of small amounts of sulfur (<500 ppm).
ChemInform Abstract: C2‐Symmetric N,N′‐Bis(terpenyl)ethylenediamines — Synthesis and Application in the Enantioselective Nitroaldol Reaction.
Authors: Malhotra Sanjay V. , Brown Herbert C. 
Published: November 2014

AbstractOptically pure ethylenediamines are prepared and screened for the enantioselective nitroaldol reaction.
ChemInform Abstract: Nickel‐Catalyzed Asymmetric Ring Opening of Oxabenzonorbornadienes with Arylboronic Acids.
Authors: Zeng Zhongyi , Yang Dingqiao , Long Yuhua , Pan Xuejing , Huang Guobao , Zuo Xiongjun , Zhou Wen 
Published: November 2014

AbstractIn comparison to related transition metal‐catalyzed protocols, this procedure is characterized by utilization of a cheaper catalyst precursor, low catalyst loading, higher efficiency, enantioselectivity, and functional group tolerance.
ChemInform Abstract: Double Axial Chirality Promoted Asymmetric [2,3] Stevens Rearrangement of N‐Cinnamyl L‐Alanine Amide‐Derived Ammonium Ylides.
Authors: Tayama Eiji , Naganuma Noriko , Iwamoto Hajime , Hasegawa Eietsu 
Published: November 2014

AbstractThe Stevens rearrangement proceeds via a double axially chiral intermediate.
ChemInform Abstract: Trifluoroacetic Acid Catalyzed Thiophenylmethylation and Thioalkylmethylation of Lactams and Phenols via Domino Three‐Component Reaction in Water.
Authors: Vishwakarma Ram A. , et al. et al. 
Published: November 2014

AbstractA facile protocol for the three component reaction of thiols and formaldehyde with lactams or isatins to give the corresponding N‐substituted compounds is presented.
ChemInform Abstract: A Pd‐Catalyzed Cascade Reaction of N—H Insertion and Oxidative Dehydrogenative Aromatization: A New Entry to 2‐Amino‐phenols.
Authors: Ding Dong , Lv Xiaobing , Li Jian , Qiu Lin , Xu Guangyang , Sun Jiangtao 
Published: November 2014

AbstractThe use of piperidine and pyrrolidine as amine substrates fails to give the desired products.
ChemInform Abstract: One Pot Direct Synthesis of β‐Ketoesters via Carbonylation of Aryl Halides Using Cobalt Carbonyl.
Authors: Baburajan Poongavanam , Elango Kuppanagounder P. 
Published: November 2014

AbstractMicrowave assisted three‐component reaction of aryl bromides and iodides with carbon monoxide and potassium mono ethyl malonate allows the synthesis of a wide variety of β‐ketoesters.
ChemInform Abstract: Novel One‐Pot Synthesis of Diverse γ,δ‐Unsaturated β‐Ketoesters by Thermal Cascade Reactions of Diazodicarbonyl Compounds and Enol Ethers: Transformation into Substituted 3,5‐Diketoesters.
Authors: Pandit Rameshwar Prasad , Lee Yong Rok 
Published: November 2014

AbstractWolff rearrangement of α‐diazo‐β‐ketoesters (I) and (IV) followed by trapping of the ketene intermediates with enol ethers (II) and (V) generates a variety of trans‐γ,δ‐unsaturated β‐ketoesters (III) and (VI), respectively.
ChemInform Abstract: Palladium Nanoparticles Supported in a Polymeric Membrane: An Efficient Phosphine‐Free “Green” Catalyst for Suzuki—Miyaura Reactions in Water.
Authors: Faria Vinicius W. , Oliveira Deyvid G. M. , Kurz Marcia H. S. , Goncalves Fabio F. , Scheeren Carla W. , Rosa Gilber R. 
Published: November 2014

AbstractThe title polymeric catalyst is successfully applied to Suzuki—Miyaura reactions of aryl iodides and bromides in water as the solvent.
ChemInform Abstract: An Expeditious Approach to Highly Functionalized Angularly Fused 5—5—n Ring Systems Through Ring Opening—Ring Closing Metathesis of Norbornene Derivatives.
Authors: Datta Ritabrata , Bose Sritama , Viththlbhai Pipaliya B. , Ghosh Subrata 
Published: November 2014

AbstractA facile protocol is reported for the synthesis of angularly fused 5,5,5‐, 5,5,6‐ and 5,5,7‐ring systems which are present in several natural products.
ChemInform Abstract: Role of ortho‐Substituents on Rhodium‐Catalyzed Asymmetric Synthesis of β‐Lactones by Intramolecular C—H Insertions of Aryldiazoacetates.
Authors: Fu Liangbing , Wang Hengbin , Davies Huw M. L. 
Published: November 2014

AbstractOxetane products are obtained in good yields and with high levels of diastereo‐ and enantioselectivity.
ChemInform Abstract: Highly Regio‐ and Enantioselective Synthesis of Polysubstituted 2H‐Pyrroles via Pd‐Catalyzed Intermolecular Asymmetric Allylic Dearomatization of Pyrroles.
Authors: Zhuo Chun‐Xiang , Zhou Yong , You Shu‐Li 
Published: November 2014

AbstractThis is the first example using multisubstituted pyrroles as substrates in asymmetric allylic alkylation reactions.
ChemInform Abstract: One‐Pot Reactions of Nitroenamines with Anilines and Ethyl Glyoxylate.
Authors: Pilipecz Mihaly V. , Scheiber Pal , Vincze Zoltan , Varga Tamas R. , Toth Gabor , Nemes Peter 
Published: November 2014

AbstractA novel three‐component method for the condensation of anilines, ethyl glyoxylate, and cyclic nitroenamines is described to yield multi‐substituted ethyl propiolates (IV).
ChemInform Abstract: Application of Nano SnO2 as a Green and Recyclable Catalyst for the Synthesis of 2‐Aryl or Alkylbenzoxazole Derivatives under Ambient Temperature
Authors: Vahdat Seyed Mohammad , Raz Shima Ghafouri , Baghery Saeed 
Published: November 2014

Abstractvia condensation reactions of 2‐aminophenols (I) with aromatic aldehydes or orthoesters
ChemInform Abstract: An Efficient Microwave‐Assisted Synthesis and Antimicrobial Activity of Novel 2‐Amino 3‐Cyano Pyridine Derivatives Using Two Reusable Solid Acids as Catalysts.
Authors: Thakrar Shailesh , Bavishi Abhay , Radadiya Ashish , Vala Hardevsinh , Parekh Shrey , Bhavsar Dhairya , Chaniyara Ravi , Shah Anamik 
Published: November 2014

AbstractTitle compounds are prepared under microwave irradiation in the presence of Fe(III)‐montmorillonite K10 or zeolite HY.
ChemInform Abstract: Facile Synthesis of 2‐Amino‐3‐bromoquinolines by Palladium‐Catalyzed Isocyanide Insertion and Cyclization of gem‐Dibromovinylanilines.
Authors: Jiang Baishan , Hu Langxi , Gui Weijun 
Published: November 2014

AbstractThe optimized conditions allow the synthesis of 3‐bromoquinoline derivatives in good yields from gem‐dibromovinylanilines and tert‐butylisocyanide.
ChemInform Abstract: Palladium Catalyzed, Heteroatom‐Guided C—H Functionalization in the Synthesis of Substituted Isoquinolines and Dihydroisoquinolines.
Authors: Tiwari Virendra Kumar , Pawar Govind Goroba , Jena Himanshu Sekhar , Kapur Manmohan 
Published: November 2014

AbstractThe crude reactions mixtures obtained after conversion of (I) or (IV) contain small to significant amounts of the corresponding 3‐arylated products which are in most cases not isolated.
ChemInform Abstract: An Efficient Ultrasound‐Assisted Synthesis of N‐Alkyl Derivatives of Carbazole, Indole, and Phenothiazine.
Authors: Zhao Sanhu , Kang Jin , Du Yuting , Kang Jingyan , Zhao Xiaoni , Xu Yinfeng , Chen Ruixi , Wang Qianqian , Shi Xitao 
Published: November 2014

AbstractN‐Heterocycles (I), (VI), and (VIII) are alkylated under ultrasonic irradiation in the presence of KOH as a base.
ChemInform Abstract: Synthesis, Characterization, and Reactivity of Novel 6H‐1,3,5‐Oxathiazine S,S‐Dioxides.
Authors: Islam Md. Rafiqul , Takikawa Yuji , Lim Kwon Taek 
Published: November 2014

AbstractS,S‐Dioxides (II) are prepared from oxathiazines (I) by oxidation with an excess of m‐chloroperbenzoic acid.
ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 76. Synthesis and Antiplatelet Evaluation of 2,4‐Disubstituted 5,6‐Dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5‐d]pyrimidines.
Authors: Okuda Kensuke , Takano Jun‐ichi , Hirota Takashi , Sasaki Kenji , Nishina Yuta , Ishida Hiroyuki 
Published: November 2014

Abstract25 Title compounds of type (IV), (VI), or (VIII) are prepared and evaluated for their antiplatelet activities.
ChemInform Abstract: Water Mediated Eco‐Friendly Green Protocol for One‐Pot Synthesis of α‐Aminophosphonates at Ambient Conditions.
Authors: Mandha Santhosh Reddy , Alla Manjula , Bommena Vittal Rao 
Published: November 2014

AbstractThe title compounds (IV) are simply obtained by reaction of various aldehydes, amines, and trimethyl phosphite under totally solvent‐free and catalyst‐free conditions.
ChemInform Abstract: A Novel Type of Luciferin from the Siberian Luminous Earthworm Fridericia heliota: Structure Elucidation by Spectral Studies and Total Synthesis.
Authors: Petushkov Valentin N. , Dubinnyi Maxim A. , Tsarkova Aleksandra S. , Rodionova Natalja S. , Baranov Mikhail S. , Kublitski Vadim S. , Shimomura Osamu , Yampolsky Ilia V. 
Published: November 2014

AbstractThe fridericia luciferin (I) is a key component of a novel ATP‐dependent bioluminescence system.
ChemInform Abstract: Wittig‐ and Horner—Wadsworth—Emmons‐Olefination Reactions with Stabilized and Semi‐Stabilized Phosphoranes and Phosphonates under Non‐classical Conditions
Authors: Al Jasem Yosef , El‐Esawi Randa , Thiemann Thies 
Published: November 2014

AbstractReview: 152 refs.
Synthesis of Cellulose Methylcarbonate in Ionic Liquids using Dimethylcarbonate
Authors: Labafzadeh Sara R. , Helminen K. Juhani , Kilpeläinen Ilkka , King Alistair W. T. 
Published: November 2014

AbstractDialkylcarbonates are viewed as low‐cost, low‐toxicity reagents, finding application in many areas of green chemistry. Homogeneous alkoxycarbonylation of cellulose was accomplished by applying dialkycarbonates (dimethyl and diethyl carbonate) in the ionic liquid‐electrolyte trioctylphosphonium acetate ([P8881][OAc])/DMSO or 1‐ethyl‐3‐methylimidazolium acetate ([emim][OAc]). Cellulose dialkylcarbonates with a moderate degree of substitution (DS∼1) are accessible via this procedure and cellulose methylcarbonate was thoroughly characterized for its chemical and physical properties after regeneration. This included HSQC & HMBC NMR, ATR‐IR, molecular weight distribution, morphology, thermal properties, and barrier properties after film formation.
Hydrolytic Stability and Hydrogen Peroxide Activation of Zirconium‐Based Oxoclusters
Authors: Faccioli Francesco , Bauer Matthias , Pedron Danilo , Sorarù Antonio , Carraro Mauro , Gross Silvia 
Published: November 2014

AbstractThe hydrolytic stability of [Zr6(OH)4O4{O(O)CC(CH3)=CH2}12] (Zr6), and [Zr6O4(OH)4{O(O)CCH2CH=CH2}12]2·6[CH2=CHCH2C(O)OH] (Zr12) oxoclusters in different environments was thoroughly investigated by FTIR, Raman, and X‐ray photoelectron spectroscopy (XPS). Specific information about the local structures around the Zr centers during the stability tests was achieved by in situ extended X‐ray absorption fine structure (EXAFS) measurements, and the exact compositions were determined by inductively coupled plasma MS (ICP‐MS) and elemental analysis. By this multidimensional spectroscopic approach, an overview on the structures formed after different treatments could be gained. The stability of the oxoclusters was then investigated in the presence of hydrogen peroxide, and the formation of peroxo–metal complexes was detected. Thus, a kinetic study was performed in acetonitrile to evaluate the performances of the oxoclusters as oxygen transfer catalysts. The oxidation of methyl p‐tolyl sulfide to the corresponding sulfoxide and sulfone was chosen as a model reaction; in some cases, an interesting selectivity towards the formation of the sulfone was found over more than 4700 catalytic cycles.
Tris(borane) Adducts of Diphosphanylmethanides: The [H3BCH(PPh2BH3)2]– Anion and Its Alkali Metal Complexes
Authors: Langer Jens , Geitner Robert , Görls Helmar 
Published: November 2014

AbstractThe reactivity of lithium complexes that contain the borane‐modified diphoshanylmethanide ligand [CH(PPh2BH3)2]– towards different Lewis base adducts of BH3 was studied to gain further insight into the mechanism of the isomerization of this derivative, which formally proceeds through a shift of one BH3 group from the phosphorus atom to the carbon atom. Whereas the use of BH3·THF in THF only resulted in the thf adduct of the starting material, [Li{CH(PPh2BH3)2}(thf)2] (1), the application of BH3·SMe2 in toluene resulted in the formation of the novel compound [(Li{H3BCH(PPh2BH3)2})∞] (2). The subsequent addition of ethereal ligands led to the isolation of [Li{H3BCH(PPh2BH3)2}(Me4thf)] (3) and [Li{H3BCH(PPh2BH3)2}(thf)3] (4). Treatment of these complexes with stronger Lewis bases such as N,N,N′,N′‐tetramethylethane‐1,2‐diamine (tmeda) results in the removal of one phosphorus‐bound BH3 molecule and the formation of the [Ph2PCH(BH3)PPh2BH3]– anion. These results indicate that the isomerization of [CH(PPh2BH3)2]– requires an additional BH3 source and a rather strong Lewis base. Complexes 1–4 and the related derivatives [Li{CH(PPh2BH3)2}(Me4THF)] (5) and [K{H3BCH(PPh2BH3)2}(dme)2] (6; dme = 1,2‐dimethoxyethane) were characterized by multinuclear NMR spectroscopy and by single‐crystal X‐ray diffraction analysis.
Room‐Temperature Direct Alkenylation of 3‐Arylsydnones
Authors: Yang Yiwen , Kuang Chunxiang 
Published: November 2014

AbstractA new efficient method for the direct alkenylation of 3‐arylsydnones by palladium‐catalyzed C–H functionalization was developed. The reaction proceeded smoothly at room temperature and delivered the product in yields up to 83 %.
Iron(II)‐Catalyzed Asymmetric Epoxidation of Trisubstituted α,β‐Unsaturated Esters
Authors: Luo Lan , Yamamoto Hisashi 
Published: November 2014

AbstractThe asymmetric epoxidation of trisubstituted α,β‐unsaturated esters was developed. The oxidation utilizes a pseudo‐C2‐symmetric iron(II) catalyst [Fe(L*)2(CH3CN)(OTf)](OTf) (Tf = trifluoromethylsulfonyl) and peracetic acid as oxidant and yields α,β‐epoxy esters with high enantiomeric purity (up to 99 % ee).
Transition‐Metal‐Free Oxidative Iodination of 1,3,4‐Oxadiazoles
Authors: Dannenberg Carl Albrecht , Bizet Vincent , Zou Liang‐Hua , Bolm Carsten 
Published: November 2014

AbstractTransition‐metal‐free oxidative iodination of 2‐substituted 1,3,4‐oxadiazoles was achieved by using sodium iodide as the halide source and Selectfluor as the oxidant. Variously substituted products were obtained in moderate to good yields under operationally straightforward conditions. Compared to existing methods for analogous conversions, the newly developed protocol appears synthetically attractive.
Fate and effects of clothianidin in fields using conservation practices
Authors: de Perre Chloé , Murphy Tracye M. , Lydy Michael J. 
Published: November 2014

Abstract

Despite the extensive use of the neonicotinoid insecticide clothianidin, and its known toxicity to beneficial insects such as pollinators, little attention has been given to its fate under agricultural field conditions. The present study investigated the fate and toxicity of clothianidin applied every other year as a corn seed-coating at 2 different rates, 0.25 mg/seed and 0.50 mg/seed, in an agricultural field undergoing a corn–soybean annual rotation, and conservation tillage. Concentrations were measured in soil, surface runoff, infiltration, and groundwater from 2011 to 2013. Clothianidin was detected at low concentrations in soil and water throughout the 2-yr corn and soybean rotation. Low and no-tillage had little or no effect on clothianidin concentrations. Laboratory toxicity bioassays were performed on nontarget species, including Daphnia magna, Hyalella azteca, Chironomus dilutus, Pimephales promelas and Eisenia fetida. Risk quotients were calculated from clothianidin concentrations measured in the field and compared with the laboratory toxicity bioassay results to assess the environmental risk of the insecticide. The risk quotient was found to be lower than the level of concern for C. dilutus, which was the most sensitive species tested; therefore, no short-term environmental risk was expected for the species investigated in the present study. Environ Toxicol Chem 2014;9999:1–8. © 2014 SETAC
Multimodal neuroimaging evidence of alterations in cortical structure and function in HIV‐infected older adults
Authors: Wilson Tony W. , Heinrichs‐Graham Elizabeth , Becker Katherine M. , Aloi Joseph , Robertson Kevin R. , Sandkovsky Uriel , White Matthew L. , O'Neill Jennifer , Knott Nichole L. , Fox Howard S. , Swindells Susan 
Published: November 2014

AbstractCombination antiretroviral therapy transformed human immunodefiency virus (HIV)‐infection from a terminal illness to a manageable condition, but these patients remain at a significantly elevated risk of developing cognitive impairments and the mechanisms are not understood. Some previous neuroimaging studies have found hyperactivation in frontoparietal networks of HIV‐infected patients, whereas others reported aberrations restricted to sensory cortices. In this study, we utilize high‐resolution structural and neurophysiological imaging to determine whether alterations in brain structure, function, or both contribute to HIV‐related cognitive impairments. HIV‐infected adults and individually matched controls completed 3‐Tesla structural magnetic resonance imaging (sMRI) and a mechanoreception task during magnetoencephalography (MEG). MEG data were examined using advanced beamforming methods, and sMRI data were analyzed using the latest voxel‐based morphometry methods with DARTEL. We found significantly reduced theta responses in the postcentral gyrus and increased alpha activity in the prefrontal cortices of HIV‐infected patients compared with controls. Patients also had reduced gray matter volume in the postcentral gyrus, parahippocampal gyrus, and other regions. Importantly, reduced gray matter volume in the left postcentral gyrus was spatially coincident with abnormal MEG responses in HIV‐infected patients. Finally, left prefrontal and postcentral gyrus activity was correlated with neuropsychological performance and, when used in conjunction, these two MEG findings had a sensitivity and specificity of over 87.5% for HIV‐associated cognitive impairment. This study is the first to demonstrate abnormally increased activity in association cortices with simultaneously decreased activity in sensory areas. These MEG findings had excellent sensitivity and specificity for HIV‐associated cognitive impairment, and may hold promise as a potential disease marker. Hum Brain Mapp 36:897–910, 2015. © 2014 Wiley Periodicals, Inc.
Light‐emitting diode therapy in exercise‐trained mice increases muscle performance, cytochrome c oxidase activity, ATP and cell proliferation
Authors: Ferraresi Cleber , Parizotto Nivaldo Antonio , Pires de Sousa Marcelo Victor , Kaippert Beatriz , Huang Ying‐Ying , Koiso Tomoharu , Bagnato Vanderlei Salvador , Hamblin Michael R. 
Published: November 2014

Light‐emitting diode therapy (LEDT) applied over the leg, gluteus and lower‐back muscles of mice using a LED cluster (630 nm and 850 nm, 80 mW/cm2, 7.2 J/cm2) increased muscle performance (repetitive climbing of a ladder carrying a water‐filled tube attached to the tail), ATP and mitochondrial metabolism; oxidative stress and proliferative myocyte markers in mice subjected to acute and progressive strength training. Six bi‐daily training sessions LEDT‐After and LEDT‐Before‐After regimens more than doubled muscle performance and increased ATP more than tenfold. The effectiveness of LEDT on improving muscle performance and recovery suggest applicability for high performance sports and in training programs.
Positioning of the mice and light‐emitting diode therapy (LEDT) applied on mouse legs, gluteus and lower‐back muscles without contact.magnified imagePositioning of the mice and light‐emitting diode therapy (LEDT) applied on mouse legs, gluteus and lower‐back muscles without contact.
Fortification of instant coffee beverages – influence of functional ingredients, packaging material and storage time on physical properties of newly formulated, enriched instant coffee powders
Authors: Benković Maja , Srečec Siniša , Špoljarić Igor , Mršić Gordan , Bauman Ingrid 
Published: November 2014

AbstractBACKGROUNDConsumer demands for healthy, functional foods are growing rapidly nowadays. Coffee, as one of the most widespread commodities, represents an interesting aspect for enrichment, since it is consumed by millions of people on a daily basis. The aim of this study was to formulate enriched instant coffee powders with the purpose of estimating the influence of storage time, functional ingredients and packaging material on physical and sensory properties of the mixtures.RESULTSStorage time of 6 months significantly (P <0.05) influenced moisture content of the mixtures, which rose linearly with an increase in storage time. Packaging material proved to be an important variable affecting moisture content, particle size, colour and cohesion index. Functional ingredients (vitamins A and C, iron, inulin and oligofructose) influenced particle size, dispersibility, wettability and, in terms of sensory analysis, grades for aftertaste, chemical taste and overall acceptability.CONCLUSIONAddition of functional ingredients significantly influenced some particle size distribution parameters and reconstitution properties, causing an increase in wettability and dispersibility times. Furthermore, in sensory terms, it influenced aftertaste and chemical taste grades. Packaging material significantly influenced moisture content, some particle size distribution parameters, colour and cohesion index. © 2014 Society of Chemical Industry