bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the opinions of others on variety‐seeking behavior
Authors: Chuang Shih‐Chieh , Cheng Yin‐Hui , Wang Sui‐Min , Cheng Shu‐Yu 
Published: May 2013

AbstractOne reason for consumer variety‐seeking behavior is interpersonal motivation. Building on previous theories, we suggest that the different information types of interpersonal sources influence the variety‐seeking behavior of individuals. Two laboratory experiments are conducted to examine the influence of the opinions of others on such behavior. The results support the author's contention that to derive more enjoyment from a shared product, an individual will make choices congruent with the opinions of others in online information. The managerial implications and study limitations are also discussed.
The drinker and the nurturer: College students' perceptions of men and fathers
Authors: Troilo Jessica 
Published: May 2013

AbstractThis three‐part study examined 421 mid‐Atlantic university students' perceptions of the content of social stereotypes related to fathers‐ and men‐in‐general. College students viewed men‐in‐general as having far fewer positive parenting and personal qualities, but generally did not differ in breadwinning characteristics when compared to fathers‐in‐general. The results empirically supported the notion that younger adults generally do not view men‐in‐general as having the qualities associated with active fathering (e.g., being physically, financially, or emotionally involved with children), although they are seen as comparable providers. Men‐in‐general also are viewed much more negatively than fathers‐in‐general. Implications of the findings are discussed.
Social communication disorder outside autism? A diagnostic classification approach to delineating pragmatic language impairment, high functioning autism and specific language impairment
Authors: Gibson Jenny , Adams Catherine , Lockton Elaine , Green Jonathan 
Published: May 2013

BackgroundDevelopmental disorders of language and communication present considerable diagnostic challenges due to overlapping of symptomatology and uncertain aetiology. We aimed to further elucidate the behavioural and linguistic profile associated with impairments of social communication occurring outside of an autism diagnosis.MethodsSix to eleven year olds diagnosed with pragmatic language impairment (PLI), high functioning autism (HFA) or specific language impairment (SLI) were compared on measures of social interaction with peers (PI), restricted and repetitive behaviours/interests (RRBIs) and language ability. Odds ratios (OR) from a multinomial logistic regression were used to determine the importance of each measure to diagnostic grouping.MANOVAwas used to investigate differences in subscale scores for thePImeasure.ResultsGreater degrees ofPIdifficulties (OR = 1.22, 95%CI = 1.05–1.41),RRBI(OR = 1.23, 95%CI = 1.06–1.42) and expressive language ability (OR = 1.16, 95%CI = 1.03–1.30) discriminatedHFAfromPLI.PLIwas differentiated fromSLIby elevatedPIdifficulties (OR = 0.82, 95%CI = 0.70–0.96) and higher expressive language ability (OR = 0.88, 95%CI = 0.77–0.98), but indistinguishable fromSLIusingRRBI(OR = 1.01, 95%CI=0.94–1.09). A significant effect of group onPIsubscales was observed (θ = 1.38, F(4, 56) = 19.26,p < .01) andPLIandHFAgroups shared a similarPIsubscale profile.ConclusionsResults provide empirical support for a conceptualisation ofPLIas a developmental impairment distinguishable fromHFAby absence ofRRBIs and by the presence of expressive language difficulties.PIdifficulties appear elevated inPLIcompared withSLI, but may be less pervasive than inHFA. Findings are discussed with reference to the proposed new category of ‘social communication disorder’ inDSM‐5.
Facultative use of thelytokous parthenogenesis for queen production in the polyandrous ant Cataglyphis cursor
Authors: Doums C. , Cronin A. L. , Ruel C. , Fédérici P. , Haussy C. , Tirard C. , Monnin T. 
Published: May 2013

AbstractThe evolutionary paradox of sex remains one of the major debates in evolutionary biology. The study of species capable of both sexual and asexual reproduction can elucidate factors important in the evolution of sex. One such species is the ant Cataglyphis cursor, where the queen maximizes the transmission of her genes by producing new queens (gynes) asexually while simultaneously maintaining a genetically diverse workforce via the sexual production of workers. We show that the queen can also produce gynes sexually and may do so to offset the costs of asexual reproduction. We genotyped 235 gynes from 18 colonies and found that half were sexually produced. A few colonies contained both sexually and asexually produced gynes. Although workers in this species can also use thelytoky, we found no evidence of worker production of gynes based on genotypes of 471 workers from the six colonies producing sexual gynes. Gynes are thus mainly, and potentially exclusively, produced by the queen. Simulations of gynes inbreeding level following one to ten generations of automictic thelytoky suggest that the queen switches between or combines thelytoky and sex, which may reduce the costs of inbreeding. This is supported by the relatively small size of inbred gynes in one colony, although we found no relationship between the level of inbreeding and immune parameters. Such facultative use of sex and thelytoky by individual queens contrasts with other known forms of parthenogenesis in ants, which are typically characterized by distinct lineages specializing in one strategy or the other.
Screening for rheumatic heart disease in Aboriginal and Torres Strait Islander children
Authors: Rémond Marc Gerard Wootton , Wark Emma Kathleen , Maguire Graeme Paul 
Published: May 2013

AbstractRheumatic heart disease is preventable but causes significant morbidity and mortality in Aboriginal Australian and Torres Strait Islander populations. Screening echocardiography has the potential to detect early rheumatic heart disease thereby enabling timely commencement of treatment (secondary prophylaxis) to halt disease progression. However, a number of issues prevent echocardiographic screening for rheumatic heart disease satisfying the Australian criteria for acceptable screening programs. Primarily, it is unclear what criteria should be used to define a positive screening result as questions remain regarding the significance, natural history and potential treatment of early and subclinical rheumatic heart disease. Furthermore, at present the delivery of secondary prophylaxis in Australia remains suboptimal such that the potential benefits of screening would be limited. Finally, the impact of echocardiographic screening for rheumatic heart disease on local health services and the psychosocial health of patients and families are yet to be ascertained.
Efficient Allocation of Radio Spectrum
Authors: FREYENS BENOÎT PIERRE , JONES CHRIS 
Published: May 2013

AbstractLegislative reforms in Anglo‐American countries require governments to account for efficient spectrum usage subject to interference control. New spectrum governance regimes promote flexible and competitive usage but the broadcasting industry remains exempt from reforms, at a significant cost to society. The need to liberalize broadcast spectrum cannot be overstated, but how should we select among alternative deregulatory regimes? In a simple stylized model we formalize the welfare effects of allocating licenses for using bandwidth on broadcast spectrum. We provide optimality conditions for entry, spectrum usage, and congestion levels under different market conditions, which allows us to justify the selection of specific governance arrangements.
Establishment of pacemaker activity in tissues allotransplanted with interstitial cells of Cajal
Authors: McCann C. J. , Hwang S. J. , Bayguinov Y. , Colletti E. J. , Sanders K. M. , Ward S. M. 
Published: May 2013

AbstractBackgroundLoss or disruption of Kit+‐interstitial cells of Cajal (ICC) capable of generating pacemaker activity has been implicated in the development of numerous gastrointestinal motility disorders. We sought to develop a model where ICC could be allotransplanted into intestines naturally devoid of these cells.MethodsEnzymatically dispersed cells from the intestinal tunica muscularis of Kit+/copGFP and KitV558Δ/+ gain‐of‐function mice were allotransplanted into myenteric plexus regions of W/WV mutant intestines that lack ICC at the level of the myenteric plexus (ICC‐MY) and pacemaker activity. Immunohistochemical analysis fate mapped the development of ICC‐MY networks and intracellular microelectrode recordings provided evidence for the development of functional pacemaker activity.Key ResultsKit+‐ICC developed into distinct networks at the level of the myenteric plexus in organotypic cultures over 28 days and displayed robust rhythmic pacemaker activity.Conclusions & InferencesThis study demonstrates the feasibility of allotransplantation of ICC into the myenteric region of the small intestine and the establishment of functional pacemaker activity into tissues normally devoid of ICC‐MY and slow waves, thus providing a possible basis for the therapeutic treatment of patients where ICC networks have been disrupted due to a variety of pathophysiological conditions.
Curcumin acts via transient receptor potential vanilloid‐1 receptors to inhibit gut nociception and reverses visceral hyperalgesia
Authors: Zhi L. , Dong L. , Kong D. , Sun B. , Sun Q. , Grundy D. , Zhang G. , Rong W. 
Published: May 2013

AbstractBackgroundAn antinociceptive effect has been reported for curcumin in animal models and in humans, but the molecular mechanisms of curcumin's effect remain undefined. In this study, we explored the possibility that curcumin inhibit visceral nociception via antagonizing the transient receptor potential vanilloid‐1 (TRPV1) receptor.MethodsThe effects of curcumin were explored using two experimental models: viscero‐motor response (VMR) to colorectal distension (CRD) in rats and jejunal afferent firing in the ex vivo mouse jejunum preparations [TRPV1 knockout (KO) and wild‐type mice, naive and trinitrobenzene sulfonic acid (TNBS)‐treated Kunming mice]. In addition, capsaicin‐induced calcium transients and whole‐cell currents were examined in acutely dissociated dorsal root ganglia (DRG) neurons.Key ResultsIn the anesthetized rat, curcumin (4 mg kg−1 min−1 for 3 min) caused a marked and rapidly reversible inhibition of CRD‐induced VMRs. In the mouse jejunum, the mesenteric afferent nerve response to ramp distension was attenuated by curcumin (3, 10 μmol L−1), an effect that was significantly reduced in TRPV1 KO mice compared with wild‐type (WT) controls. Moreover, in WT mice, curcumin (1–30 μmol L−1) was found to inhibit the afferent responses to capsaicin in a concentration‐dependent manner. Trinitrobenzene sulfonic acid‐induced hypersensitivity of jejunal afferents was also attenuated by curcumin. Curcumin potently inhibited capsaicin‐induced rise in intracellular calcium and inward currents in mouse or rat DRG neurons.Conclusions & InferencesOur results provide strong evidence that curcumin inhibit visceral nociception via antagonizing TRPV1 and may be a promising lead for the treatment of functional gastrointestinal diseases.
Sequence‐based SNP genotyping in durum wheat
Authors: van Poecke Remco M.P. , Maccaferri Marco , Tang Jifeng , Truong Hoa T. , Janssen Antoine , van Orsouw Nathalie J. , Salvi Silvio , Sanguineti Maria C. , Tuberosa Roberto , van der Vossen Edwin A.G. 
Published: May 2013

SummaryMarker development for marker‐assisted selection in plant breeding is increasingly based on next‐generation sequencing (NGS). However, marker development in crops with highly repetitive, complex genomes is still challenging. Here we applied sequence‐based genotyping (SBG), which couples AFLP®‐based complexity reduction to NGS, for de novo single nucleotide polymorphisms (SNP) marker discovery in and genotyping of a biparental durum wheat population. We identified 9983 putative SNPs in 6372 contigs between the two parents and used these SNPs for genotyping 91 recombinant inbred lines (RILs). Excluding redundant information from multiple SNPs per contig, 2606 (41%) markers were used for integration in a pre‐existing framework map, resulting in the integration of 2365 markers over 2607 cM. Of the 2606 markers available for mapping, 91% were integrated in the pre‐existing map, containing 708 SSRs, DArT markers, and SNPs from CRoPS technology, with a map‐size increase of 492 cM (23%). These results demonstrate the high quality of the discovered SNP markers. With this methodology, it was possible to saturate the map at a final marker density of 0.8 cM/marker. Looking at the binned marker distribution (Figure 2), 63 of the 268 10‐cM bins contained only SBG markers, showing that these markers are filling in gaps in the framework map. As to the markers that could not be used for mapping, the main reason was the low sequencing coverage used for genotyping. We conclude that SBG is a valuable tool for efficient, high‐throughput and high‐quality marker discovery and genotyping for complex genomes such as that of durum wheat.
On lower bounds for the Ihara constants and
Authors: Duursma Iwan , Mak Kit-Ho 
Published: May 2013

AbstractLet$ \mathcal{X} $be a curve over${ \mathbb{F} }_{q} $and let$N( \mathcal{X} )$,$g( \mathcal{X} )$be its number of rational points and genus respectively. The Ihara constant$A(q)$is defined by$A(q)= {\mathrm{lim~sup} }_{g( \mathcal{X} )\rightarrow \infty } N( \mathcal{X} )/ g( \mathcal{X} )$. In this paper, we employ a variant of Serre’s class field tower method to obtain an improvement of the best known lower bounds on$A(2)$and$A(3)$.
Big graph mining
Authors: Kang U. , Faloutsos Christos 
Published: May 2013

How do we find patterns and anomalies in very large graphs with billions of nodes and edges? How to mine such big graphs efficiently? Big graphs are everywhere, ranging from social networks and mobile call networks to biological networks and the World Wide Web. Mining big graphs leads to many interesting applications including cyber security, fraud detection, Web search, recommendation, and many more.
In this paper we describe Pegasus, a big graph mining system built on top of MapReduce, a modern distributed data processing platform. We introduce GIM-V, an important primitive that Pegasus uses for its algorithms to analyze structures of large graphs. We also introduce HEigen, a large scale eigensolver which is also a part of Pegasus. Both GIM-V and HEigen are highly optimized, achieving linear scale up on the number of machines and edges, and providing 9.2x and 76x faster performance than their naive counterparts, respectively.
Using Pegasus, we analyze very large, real world graphs with billions of nodes and edges. Our findings include anomalous spikes in the connected component size distribution, the 7 degrees of separation in a Web graph, and anomalous adult advertisers in the who-follows-whom Twitter social network.
Notch1 Promotes the Pro-Osteogenic Response of Human Aortic Valve Interstitial Cells via Modulation of ERK1/2 and Nuclear Factor-κB Activation
Authors: Zeng Qingchun , Song Rui , Ao Lihua , Weyant Michael J. , Lee Joon , Xu Dingli , Fullerton David A. , Meng Xianzhong 
Published: May 2013

Objective—
Calcific aortic valve disease is a leading cardiovascular disease in the elderly, and progressive calcification results in the failure of valvular function. Aortic valve interstitial cells (AVICs) from stenotic valves express higher levels of bone morphogenetic protein-2 in response to Toll-like receptor 4 stimulation. We recently found that Toll-like receptor 4 interacts with Notch1 in human AVICs. This study tests the hypothesis that Notch1 promotes the pro-osteogenic response of human AVICs.

Approach and Results—
AVICs isolated from diseased human valves expressed higher levels of bone morphogenetic protein-2 and alkaline phosphatase after lipopolysaccharide stimulation. The augmented pro-osteogenic response is associated with elevated cellular levels of Notch1 and enhanced Notch1 cleavage in response to lipopolysaccharide stimulation. Inhibition or silencing of Notch1 suppressed the pro-osteogenic response in diseased cells, and the Notch 1 ligand, Jagged1, enhanced the response in AVICs isolated from normal human valves. Interestingly, extracellular signal-regulated protein kinases 1/2 (ERK1/2) and nuclear factor-κB phosphorylation induced by lipopolysaccharide was markedly reduced by inhibition or silencing of Notch1 and enhanced by Jagged1. Inhibition of ERK1/2 or nuclear factor-κB also reduced bone morphogenetic protein-2 and alkaline phosphatase expression induced by lipopolysaccharide.

Conclusions—
Notch1 mediates the pro-osteogenic response to Toll-like receptor 4 stimulation in human AVICs. Elevated Notch1 levels and enhanced Notch1 activation play a major role in augmentation of the pro-osteogenic response of AVICs of stenotic valves through modulation of ERK1/2 and nuclear factor-κB activation. These pathways could be potential therapeutic targets for prevention of the progression of calcific aortic valve disease.
Statins Exert the Pleiotropic Effects Through Small GTP-Binding Protein Dissociation Stimulator Upregulation With a Resultant Rac1 Degradation
Authors: Tanaka Shin-ichi , Fukumoto Yoshihiro , Nochioka Kotaro , Minami Tatsuro , Kudo Shun , Shiba Nobuyuki , Takai Yoshimi , Williams Carol L. , Liao James K. , Shimokawa Hiroaki 
Published: May 2013

Objective—
The pleiotropic effects of 3-hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors (statins) independent of cholesterol-lowering effects are thought to be mediated through inhibition of the Rho/Rho-kinase pathway. However, we have previously demonstrated that the pleiotropic effects of regular-dose statins are mediated mainly through inhibition of the Rac1 signaling pathway rather than the Rho/Rho-kinase pathway, although the molecular mechanisms of the selective inhibition of the Rac1 signaling pathway by regular-dose statins remain to be elucidated. In this study, we tested our hypothesis that small GTP-binding protein GDP dissociation stimulator (SmgGDS) plays a crucial role in the molecular mechanisms of the Rac1 signaling pathway inhibition by statins in endothelial cells.

Approach and Results—
In cultured human umbilical venous endothelial cells, statins concentration-dependently increased SmgGDS expression and decreased nuclear Rac1. Statins also enhanced SmgGDS expression in mouse aorta. In control mice, the protective effects of statins against angiotensin II–induced medial thickening of coronary arteries and fibrosis were noted, whereas in SmgGDS-deficient mice, the protective effects of statins were absent. When SmgGDS was knocked down by its small interfering RNA in human umbilical venous endothelial cells, statins were no longer able to induce Rac1 degradation or inhibit angiotensin II–induced production of reactive oxygen species. Finally, in normal healthy volunteers, statins significantly increased SmgGDS expression with a significant negative correlation between SmgGDS expression and oxidative stress markers, whereas no correlation was noted with total or low-density lipoprotein-cholesterol.

Conclusions—
These results indicate that statins exert their pleiotropic effects through SmgGDS upregulation with a resultant Rac1 degradation and reduced oxidative stress in animals and humans.
Calvin’s Geneva Confronts Magic and Witchcraft: The Evidence from the Consistory
Authors: Watt Jeffrey R. 
Published: May 2013

Abstract
This essay examines the actions of the Consistory of Geneva, a morals court created and dominated by John Calvin, against reputed cases of magic and superstition. During the ministry of Calvin, the most common of these involved white magic to cure people of various illnesses. The Consistory was not unduly harsh in dealing with therapeutic magic, usually just rebuking the miscreants and temporarily excluding them from communion. It also showed a remarkable degree of skepticism when confronting accusations of maleficia, at times viewing the allegations as a form of defamation of the person accused of witchcraft. The Consistory, like the Catholic Inquisition, attacked superstition, but it extended superstition to include numerous practices that Catholics accepted. Calvinism’s elimination of many rituals and sacramentals greatly restricted access to the supernatural. Evidence from the Consistory suggests that Calvinism promoted the professionalization of medicine and, in the long run, the disenchantment of the world.
Orthodox Reform in Seventeenth-Century Kiev: The Evidence of a Library
Authors: Charipova Liudmila V. 
Published: May 2013

Abstract
Drawing on the surviving lists of books from the private collection of Peter Mohyla, the Greek Orthodox Metropolitan of Kiev in 1633-1646, the crucial period that followed the restoration of his confession’s legal status in the Polish-Lithuanian Commonwealth, the article examines the place of Western monastic works in shaping the spiritual and doctrinal parameters of Orthodox reform. Beginning in the Archdiocese of Kiev, it subsequently spread to other branches of the Eastern Church, which remained outside communion with Rome in the seventeenth century: Greek, Moldavian, and Russian. The article establishes vital links between the process of Orthodox renewal and the European movement for religious change and considers the case for the applicability of the confessionalization model as a suitable analytical framework for Orthodox religious reforms.
“Chinese, but not quite”: Huaqiaoand the Marginalization of the Overseas Chinese
Authors: Ong Soon Keong 
Published: May 2013

Abstract
This article reflects on the representations of overseas Chinese in Chinese political and popular discourses from the late Qing to World War II. It argues that contrary to prevalent views, which credit the success of the Chinese nationalist discourse in mobilizing the overseas Chinese to their re-incorporation into the Chinese nation, extraterritorial Chinese nationalism depended not so much on the rhetoric of inclusion, but rather on the separation of the overseas Chinese as a sub-ethnic group, particularly after they were “rebranded” as huaqiao, or Chinese sojourners. This analysis begins by looking at the key reasons for Chinese political activists’ newfound interest in the diasporas — in soliciting huaqiao contributions to China’s state-building projects — and argues that they imbued huaqiao with certain positive qualities only insofar as these made them relevant to China. The truth is, prejudices against the emigrants have persisted and Chinese within China continue to view huaqiao as uncouth, uncultured, and even “unChinese.”