bluuebunny/crossref_metadata_2025_split huggingface dataset:
Variability of lipid and lipoprotein concentrations during puberty in Brazilian boys
Authors: Mascarenhas Luis Paulo Gomes , Leite Neiva , Titski Ana Cláudia C. Kapp , Brito Lilian Messias Sampaio , Boguszewski Margaret C.S. 
Published: August 2014

AbstractEvaluation of lipid profile in children and adolescents is important for early diagnosis of dyslipidemias. Physiological changes might be observed in the concentration of the lipid profile components, according to the stage of sexual maturation.To evaluate the variation in lipid and lipoprotein concentrations in boys during puberty.The sample consisted of 570 male adolescents with ages between 10 and 17 years. Weight, height, and body mass index (BMI) were assessed. Total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), and triglyceride (TG) were determined by the enzymatic method, and low-density lipoprotein cholesterol (LDL-C) was calculated. Puberty was classified according to Tanner references. The percentile criterion was adopted for the distribution and identification of lipoprotein levels. The analysis of variance and description tests with p<0.05 was applied.Participants had similar BMILipid and lipoprotein concentrations tend to undergo changes during puberty in boys. The use of percentile values can be very useful to track variations in lipid and lipoprotein levels during the maturation process.
Production of 111In and
114mIn by proton induced reactions: an update on
excitation functions, chemical separation – purification and
recovery of target material
Authors: Hermanne Alex , Adam-Rebeles Razvan , Van den Winkel Pierre , Tárkányi Ferenc , Takács Sandor 
Published: August 2014

Abstract
In order to update the recommended cross section data of IAEA for
production of 111In and 114m
In through the
112Cd(p,2n) and 114Cd(p,n) reactions new
measurements were performed. In stacked-foil irradiations with
incident proton energy of 36.7 and 25 MeV on highly enriched
112Cd and 114Cd targets, the excitation functions
for 109,110g,110m,111,113m,114m
In were determined, relative
to the monitor reactions
nat
Cu(p,x)62,65Zn. The
results are compared with the available literature values (also
extracted from measurements on
nat
Cd) and with data listed
in the on-line library TENDL-2012 (calculated with the TALYS 1.4
theoretical code).
The industrial, PC-controlled automated dissolution and separation
chemistry apparatus for delivery of large quantities of nca
111In and the recovery of enriched 112Cd from
processed irradiated targets are described.
Technical Challenges for Big Data in Biomedicine and Health: Data Sources, Infrastructure, and Analytics
Authors: Holmes J. H. , Sun J. , Peek N. 
Published: August 2014

Summary
Objectives: To review technical and methodological challenges for big data research in biomedicine and health.
Methods: We discuss sources of big datasets, survey infrastructures for big data storage and big data processing, and describe the main challenges that arise when analyzing big data. Results: The life and biomedical sciences are massively contributing to the big data revolution through secondary use of data that were collected during routine care and through new data sources such as social media. Efficient processing of big datasets is typically achieved by distributing computation over a cluster of computers. Data analysts should be aware of pitfalls related to big data such as bias in routine care data and the risk of false-positive findings in high-dimensional datasets. Conclusions: The major challenge for the near future is to transform analytical methods that are used in the biomedical and health domain, to fit the distributed storage and processing model that is required to handle big data, while ensuring confidentiality of the data being analyzed.
Trends on Integrating Framework of Applications or Data
Authors: Conchon E. , Bricon-Souf N. ,   Section Editors for the IMIA Yearbook Section on Health and Clinical Management
Published: August 2014

Summary
Objective: To summarize current excellent research and trends in the field of Health and Clinical management.
Methods: Synopsis of the articles selected for the IMIA Yearbook 21014
Results: A comprehensive review of papers published in 2013 was performed by querying PubMed. 1079 were reviewed as papers without authors, without abstract or smaller than 4 pages were excluded from the selection. The editors reviewed all papers and 15 papers selected and provided to to international reviewers. Four papers from international peer-reviewed journals were finally selected for the Health and Clinical Management section.
Conclusion: Many telemedicine applications are tested nowadays in medical situation, but the challenges emphasized by the best papers selection focus on the ability of proposing integrative frameworks for applications or data in order to handle efficiency of health and clinical management.
A 2014 Medical Informatics Perspective on Clinical Decision Support Systems: Do We Hit The Ceiling of Effectiveness?
Authors: Lamy J.-B. , Bouaud J. ,   Section Editors for the IMIA Yearbook Section on Decision Support
Published: August 2014

Summary
Objective: To summarize recent research and propose a selection of best papers published in 2013 in the field of computer-based decision support in health care.
Method: Two literature reviews were performed by the two section editors from bibliographic databases with a focus on clinical decision support systems (CDSSs) and computer provider order entry in order to select a list of candidate best papers to be peer-reviewed by external reviewers.
Results: The full review process highlighted three papers, illustrating current trends in the domain of clinical decision support. The first trend is the development of theoretical approaches for CDSSs, and is exemplified by a paper proposing the integration of family histories and pedigrees in a CDSS. The second trend is illustrated by well-designed CDSSs, showing good theoretical performances and acceptance, while failing to show a clinical impact. An example is given with a paper reporting on scorecards aiming to reduce adverse drug events. The third trend is represented by research works that try to understand the limits of CDSS use, for instance by analyzing interactions between general practitioners, patients, and a CDSS.
Conclusions: CDSSs can achieve good theoretical results in terms of sensibility and specificity, as well as a good acceptance, but evaluations often fail to demonstrate a clinical impact. Future research is needed to better understand the causes of this observation and imagine new effective solutions for CDSS implementation.
Managing Large-Scale Genomic Datasets and Translation into Clinical Practice
Authors: Soualmia L. F. , Lecroq T. ,   Section Editors for the IMIA Yearbook Section on Bioinformatics and Translational Informatics
Published: August 2014

Summary
Objective:To summarize excellent current research in the field of Bioinformatics and Translational Informatics with application in the health domain.
Method: We provide a synopsis of the articles selected for the IMIA Yearbook 2014, from which we attempt to derive a synthetic overview of current and future activities in the field. A first step of selection was performed by querying MEDLINE with a list of MeSH descriptors completed by a list of terms adapted to the section. Each section editor evaluated independently the set of 1,851 articles and 15 articles were retained for peer-review.
Results: The selection and evaluation process of this Yearbook’s section on Bioinformatics and Translational Informatics yielded three excellent articles regarding data management and genome medicine. In the first article, the authors present VEST (Variant Effect Scoring Tool) which is a supervised machine learning tool for prioritizing variants found in exome sequencing projects that are more likely involved in human Mendelian diseases. In the second article, the authors show how to infer surnames of male individuals by crossing anonymous publicly available genomic data from the Y chromosome and public genealogy data banks. The third article presents a statistical framework called iCluster+ that can perform pattern discovery in integrated cancer genomic data. This framework was able to determine different tumor subtypes in colon cancer.
Conclusions: The current research activities still attest the continuous convergence of Bioinformatics and Medical Informatics, with a focus this year on large-scale biological, genomic, and Electronic Health Records data. Indeed, there is a need for powerful tools for managing and interpreting complex data, but also a need for user-friendly tools developed for the clinicians in their daily practice. All the recent research and development efforts are contributing to the challenge of impacting clinically the results and even going towards a personalized medicine in the near future.
Information Technology for Clinical, Translational and Comparative Effectiveness Research
Authors: Choquet R. , Daniel C. ,   Section Editors for the IMIA Yearbook Section on Section on Clinical Research Informatics
Published: August 2014

SummaryObjective: To select and summarize key contributions to current research in the field of Clinical Research Informatics (CRI).Method: A bibliographic search using a combination of MeSH and free terms search over PubMed was performed followed by a blinded review.Results: The review process resulted in the selection of four papers illustrating various aspects of current research efforts in the area of CRI. The first paper tackles the challenge of extracting accurate phenotypes from Electronic Healthcare Records (EHRs).Privacy protection within shared de-identified, patient-level research databases is the focus of the second selected paper. Two other papers exemplify the growing role of formal representation of clinical data - in metadata repositories - and knowledge – in ontologies - for supporting the process of reusing data for clinical research.Conclusions: The selected articles demonstrate how concrete platforms are currently achieving interoperability across clinical research and care domains and have reached the evaluation phase. When EHRs linked to genetic data have the potential to shift the research focus from research driven patient recruitment to phenotyping in large population, a key issue is to lower patient re-identification risks for biomedical research databases.Current research illustrates the potential of knowledge engineering to support, in the coming years, the scientific lifecycle of clinical research.
Glycated Albumin and Calprotectin Levels in Gingival Crevicular Fluid From Patients With Periodontitis and Type 2 Diabetes
Authors: Kajiura Yukari , Bando Mika , Inagaki Yuji , Nagata Toshihiko , Kido Jun‐ichi 
Published: August 2014

Background: Patients with diabetes mellitus (DM) have a high prevalence of periodontitis. Periodontitis in these patients is characterized by severe inflammation and tissue breakdown, and its diagnosis is important for cures of periodontitis and DM. The purpose of this study is to investigate the levels of glycated albumin (GA), a DM marker, and calprotectin, an inflammatory marker, in gingival crevicular fluid (GCF) from patients with periodontitis and DM (DM‐P).Methods: The 78 participants in this study were patients with DM, chronic periodontitis (CP), DM‐P, and healthy individuals (H). GCF and blood were collected, and GA and calprotectin in GCF were analyzed using Western blotting and enzyme‐linked immunosorbent assay. Levels were compared among H, DM, CP, and DM‐P groups. Blood GA and glycated hemoglobin (HbA1c) were measured, and the correlation among GCF GA and blood HbA1c or GA levels was investigated. Receiver operating characteristic (ROC) analysis for GCF GA to predict DM was performed.Results: GA was identified in GCF, and its amount/concentration in GCF samples from DM and DM‐P were significantly higher than those of non‐DM groups (H and CP). Calprotectin amounts in GCF from CP and DM‐P were significantly higher than in H and DM groups. GCF GA level was positively correlated with blood HbA1c and GA level. ROC analysis of GCF GA showed an optimal cutoff value to predict DM.Conclusions: GA showed a high level in GCF from patients with DM. Examination of GA and calprotectin in GCF may be useful for predicting DM‐P.
Prevalence of Altered Passive Eruption in Orthodontically Treated and Untreated Patients
Authors: Nart Jose , Carrió Neus , Valles Cristina , Solís‐Moreno Carols , Nart Maria , Reñé Ramon , Esquinas Cristina , Puigdollers Andreu 
Published: August 2014

Background:Some authors have reported that after orthodontic treatment (OT), a “gummy smile” might develop. Nevertheless, there are no studies in the literature that investigate whether OT increases the presence of altered passive eruption (APE). The primary aim of this cross‐sectional study is to evaluate the prevalence of APE after OT (OT group) and compare it with patients who never received OT (control group). A secondary aim is to identify which variables are related to APE.Methods:The study population consisted of 190 patients (95 patients each in the control and OT groups), providing 1,140 anterior teeth for the clinical examination. The following clinical parameters were assessed: presence or absence of APE, clinical crown length, and gingival biotype, which was divided into three categories: thin‐scalloped, thick‐flat, and thick‐scalloped.Results:Twenty‐eight patients (29.5%) were diagnosed with APE in the control group and 40 (42.1%) in the OT group, although this difference was not statistically significant (P= 0.07). Furthermore, 34 (75.6%) patients with thick‐flat biotype were diagnosed with APE, whereas 30 (31.3%) and four (8.2%) with thick‐scalloped and thin‐scalloped biotypes, respectively, had APE. These differences were statistically significant (P<0.001).Conclusions:It was concluded that: 1) the prevalence of APE is higher after OT but not to a statistically significant degree and 2) APE is more common in individuals with a thick‐flat gingival biotype.
Impact of a Community Health Workers–Led Structured Program on Blood Glucose Control Among Latinos With Type 2 Diabetes: The DIALBEST Trial
Authors: Pérez-Escamilla Rafael , Damio Grace , Chhabra Jyoti , Fernandez Maria L. , Segura-Pérez Sofia , Vega-López Sonia , Kollannor-Samuel Grace , Calle Mariana , Shebl Fatma M. , D’Agostino Darrin 
Published: August 2014

OBJECTIVE
Latinos with type 2 diabetes (T2D) face major healthcare access and disease management disparities. We examined the impact of the Diabetes Among Latinos Best Practices Trial (DIALBEST), a community health worker (CHW)–led structured intervention for improving glycemic control among Latinos with T2D.

RESEARCH DESIGN AND METHODS
A total of 211 adult Latinos with poorly controlled T2D were randomly assigned to a standard of healthcare (n = 106) or CHW (n = 105) group. The CHW intervention comprised 17 individual sessions delivered at home by CHWs over a 12-month period. Sessions addressed T2D complications, healthy lifestyles, nutrition, healthy food choices and diet for diabetes, blood glucose self-monitoring, and medication adherence. Demographic, socioeconomic, lifestyle, anthropometric, and biomarker (HbA1c, fasting blood glucose, and lipid profile) data were collected at baseline and 3, 6, 12, and 18 months (6 months postintervention). Groups were equivalent at baseline.

RESULTS
Participants had high HbA1c at baseline (mean 9.58% [81.2 mmol/mol]). Relative to participants in the control group, CHWs had a positive impact on net HbA1c improvements at 3 months (−0.42% [−4.62 mmol/mol]), 6 months (−0.47% [−5.10 mmol/mol]), 12 months (−0.57% [−6.18 mmol/mol]), and 18 months (−0.55% [−6.01 mmol/mol]). The overall repeated-measures group effect was statistically significant (mean difference −0.51% [−5.57 mmol/mol], 95% CI −0.83, −0.19% [−9.11, −2.03 mmol/mol], P = 0.002). CHWs had an overall significant effect on fasting glucose concentration that was more pronounced at the 12- and 18-month visits. There was no significant effect on blood lipid levels, hypertension, and weight.

CONCLUSIONS
DIALBEST is an effective intervention for improving blood glucose control among Latinos with T2D.
The Mealtime Challenge: Nutrition and Glycemic Control in the Hospital
Authors: Ryan Donna B. , Swift Carrie S. 
Published: August 2014

In Brief
Multiple staff members and departments have a responsibility for various aspects of nutrition therapy for glycemic management in the hospital setting. Implementation is initiated by physicians, nurse practitioners, and physician's assistants and planned and operationalized by registered dietitians. Meals are delivered by food service staff, and nurses monitor and integrate glycemic control components into patients' medical treatment plan. Although nutrition therapy is recognized as an important aspect of care in the hospital setting, it can also be challenging to appropriately coordinate meals with blood glucose monitoring and insulin administration. This article addresses current mealtime practices and recommendations to improve these processes in acute care.
Opinions of Czech general practitioners on generic drugs and substitution
Authors: Dosedel Martin , Maly Josef , Kubena Ales , Vlcek Jiri 
Published: August 2014

Abstract
The aim of the study was to map and analyze general practitioners` opinions of, attitudes towards and experiences with generic drugs and generic substitution (GS) in the Czech Republic. General practitioners (GPs) who took part in the annual and regional professional conferences of the Society of General Practice in the period from November 2008 until March 2009 were asked to complete the 28-item questionnaire concerning the issue of generic drugs and GS. Questions were organized in 5 sections aimed at assessing the attitude towards GS, understanding the legislation and opinions on statements related to GS. All data were analyzed using descriptive statistics and correlations were tested by selected parametric and non-parametric tests. Total of 263 completed questionnaires were returned (mean age of 52.2 years (SD=13.7), 177 (67.3%) females and 248 (94.3%) GPs having a practice specialization). 99 (37.6%) respondents have considered generic drugs to be bioequivalent to the respective brand name drugs. 121 (46.0%) respondents believed that generic drugs are of lower quality than brand name drugs. None of respondent showed acquaintance with all the legal rules for GS. Awareness of the legislation and attitude towards GS correlated with the age (p<0.001). In conclusion, distrust among GPs in generic drugs derives from poor knowledge and personal experiences.
Cytokine production by leukocytes in patients with periodontitis
Authors: Sakalauskiene Jurgina , Giedrimiene Dalia , Kubilius Ricardas , Gleiznys Alvydas , Vitkauskiene Astra , Ivanauskiene Egle , Puskunigyte Kristina 
Published: August 2014

Abstract
In the present study, we investigated the relation between clinical parameters and levels of interleukin (IL) -4 and -5, and tumour necrosis factor-α (TNF-α) in the leukocyte incubation medium (LIM) obtained from 26 patients with chronic periodontitis (P) and 26 control group subjects (C). The levels of cytokines IL-4 and IL -5 produced by the LIM stimulated with non-opsonised E. coli were determined using the Enzyme-Linked Immunosorbent Assay (ELISA) method and the levels of TNF-α were evaluated by applying Enzyme Amplified Sensitivity Immunoassay (EASIA). TNF-α levels in stimulated LIM were strongly positively correlated with clinical parameters such as the pocket probing depths (PPD), the clinical attachment level (CAL), the bleeding on probing (BOP) and oral hygiene index (OHI), whereas the IL-4 and IL-5 levels in the analogous medium were strongly negatively correlated with the clinical parameters. IL-4 and IL-5 levels in stimulated LIM of P group patients were significantly lower, whereas TNF-α levels were significantly higher than that in analogous medium of C group subjects. These differences were associated with the severity of periodontal disease.
Is either arterial or venous antithrombin III level linked to outcome in elderly males versus females with severe sepsis?
Authors: Adly Nermien N , Abou-Hashema Rania M 
Published: August 2014

Objectives: We aimed to study arterial and venous ATIII levels, in elderly males and females with severe sepsis, and their impact upon the patients’ outcomes. Patients and Methods: A cohort study was performed in thirty-nine elderly patients with severe sepsis. Arterial and venous ATIII levels were measured. Sequential Organ Failure Assessment (SOFA) score was calculated. Results: Both arterial and venous ATIII levels were negatively correlated with age in the whole sample (P=0.004 and .05 consecutively) (r = −0.45 and −0.32 consecutively). There was a significant difference between the arterial and venous ATIII levels in males (P=0.04). In males, SOFA score was positively correlated with arterial ATIII and the difference between arterial and venous ATIII levels (P=0.04 and .05 consecutively). Arterial and venous ATIII were the significant predictors of SOFA score, only in males (P <0.001 and 0.003 consecutively). Conclusion: ATIII level decreased with increasing age. In males, both higher arterial and lower venous ATIII levels were significant predictors of worse organ dysfunction. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10795 Asian Journal of Medical Sciences Vol.6(1) 2015 34-39
Haemoptysis: An unusual initial presentation of achalasia cardia
Authors: Tapadar Sumit Roy , Deb Jaydip , Dhua Aparup , Bhattacharya Soumya , Bairagya Tapan Das , Biswas Uttam 
Published: August 2014

A 31 year old male presented with haemoptysis, fever and cough. Chest Radiography showed patchy consolidation with breakdown in lower lobe of left lung. Further evaluation revealed the presence of achalasia cardia that resulted haemoptysis due to aspiration pneumonia. This report highlights the uncommon initial presentation of achalasia cardia in the form of haemoptysis in a previously asymptomatic individual. Although haemoptysis occurs commonly due to pulmonary disorders, it may also be an initial symptom of some rare nonpulmonary disorder. Thorough workup with strict vigilance is extremely important to elicit that type of rare aetiology. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10800 Asian Journal of Medical Sciences Vol.6(1) 2015 103-105
Unusual cause for pacemaker threshold elevation
Authors: Yontar Osman Can , Tenekecioglu Erhan , Karaagac Kemal , Tutuncu Ahmet 
Published: August 2014

Pacing threshold is an important entity which should be tested during pacemaker follow up. Abnormal elevation of pacing threshold would end up with early exhaustion of pacemaker battery. In this report, we described a patient with an unusual cause for threshold elevation. Learning objective: Pacemaker follow-up has its own routines. Telecardiogram is one of them, however it is mostly underrated nowadays. Our objective is to teach value of this quick and inexpensive test for pacemaker patients. DOI: http://dx.doi.org/10.3126/ajms.v6i1.10801 Asian Journal of Medical Sciences Vol.6(1) 2015 106-107
Risks in Housing and Real Estate Construction Project
Authors: Koirala Madhav Prasad 
Published: August 2014

The main purpose of this paper is identify the risks involved in housing and real estate of construction projects in Nepal and ranks them as per the severity. In this research, first the risks involved in construction projects life cycle has been identified with the help of professional expertise and verified with the help of housing profession arranged in a respondent in systematic hierarchical structure. Questionnaire surveys and literature review were used for data collection. Next, based on the obtained data a network was based on the statically system has been designed for the evaluation of project risks. After data analysis, the result has been published and finally conclusion has been drawn. DOI: http://dx.doi.org/10.3126/jie.v10i1.10876Journal of the Institute of Engineering, Vol. 10, No. 1, 2014 pp. 34-44