bluuebunny/crossref_metadata_2025_split huggingface dataset:
The amino acid transporter SLC16A10 promotes melanogenesis by facilitating the transportation of phenylalanine
Authors: Luo Liping , Zeng Hongliang , Hu Yibo , Jiang Ling , Fu Chuhan , Huang Jinhua , Chen Jing , Zeng Qinghai 
Published: August 2024

AbstractPhenylalanine is a crucial amino acid in the process of melanogenesis. However, the exact mechanism by which it is transported into melanocytes has not been disclosed. The aim of this study was to identify and examine the key transporters that are responsible for phenylalanine transportation and evaluate their significance in melanogenesis. The amino acid transporter SLC16A10 was found to be up‐regulated in both melasma (GSE72140) and sun‐exposed skin (GSE67098). The protein levels of SLC16A10 were proportional to the melanin content in melanocytic nevi, indicating that SLC16A10 was related to melanogenesis. After SLC16A10 overexpression, melanin increased significantly in MNT1 cells. Meanwhile, the expression of melanogenesis‐related proteins such as TYR and TYRP1 increased, while their RNA levels did not change. Transcriptomics data indicated that SLC16A10 can enhance the function of ribosome. Furthermore, targeted metabolomics data and ELISA results demonstrated SLC16A10 mainly affected the transport of phenylalanine into the cells. Then, phenylalanine was added to the cell culture medium after SLC16A10 overexpression, melanin synthesis in cells furtherly increased, which verified that SLC16A10 enhances melanogenesis by promoting the uptake of phenylalanine. Finally, we found that SLC16A10 expression increased after UVB irradiation. Knockdown SLC16A10 reduced UVB‐induced melanin production and phenylalanine uptake by cells. In summary, SLC16A10 enhances melanogenesis by promoting the uptake of phenylalanine, and upregulation SLC16A10 is likely responsible for the UVB‐induced hyperpigmentation as well.
Class integration of ChatGPT and learning analytics for higher education
Authors: Civit Miguel , Escalona María José , Cuadrado Francisco , Reyes‐de‐Cozar Salvador 
Published: August 2024

AbstractBackgroundActive Learning with AI‐tutoring in Higher Education tackles dropout rates.ObjectivesTo investigate teaching‐learning methodologies preferred by students. AHP is used to evaluate a ChatGPT‐based studented learning methodology which is compared to another active learning methodology and a traditional methodology. Study with Learning Analytics to evaluate alternatives, and help students elect the best strategies according to their preferences.MethodsComparative study of three learning methodologies in a counterbalanced Single‐Group with 33 university students. It follows a pre‐test/post‐test approach using AHP and SAM. HRV and GSR used for the estimation of emotional states.FindingsCriteria related to in‐class experiences valued higher than test‐related criteria. Chat‐GPT integration was well regarded compared to well‐established methodologies. Student emotion self‐assessment correlated with physiological measures, validating used Learning Analytics.ConclusionsProposed model AI‐Tutoring classroom integration functions effectively at increasing engagement and avoiding false information. AHP with the physiological measuring allows students to determine preferred learning methodologies, avoiding biases, and acknowledging minority groups.
What is the Relationship Between Plant Trait Diversity and Geodiversity? A Plot‐Based, Pan‐European Analysis
Authors: Vernham Grant , Bailey Joseph J. , Field Richard , Schrodt Franziska 
Published: August 2024

ABSTRACTAimHeterogeneity of the Earth's abiotic surface and subsurface (geodiversity) is increasingly recognised as an important driver of biodiversity. Theoretically, species' traits should match to abiotic conditions in the local environment. Here, we test this for the first time at a continental extent by analysing the relationships between geodiversity and plant trait diversity in forested vegetation plots across Europe, at three plot sizes (100, 400 and 1000 m2).LocationEurope.Time Period1930–present.Major Taxa StudiedPlants.MethodsWe analysed geodiversity–trait diversity relationships across Europe at 1 km resolution using 2637 forested vegetation plots from the sPlotOpen database. We computed geodiversity (topographic, landform, wetness and soil physical and chemical heterogeneity) variables, combined with climate and land use data to analyse the direct and indirect effects of geodiversity on plant trait diversity, using structural equation modelling.ResultsTopographic heterogeneity, and annual temperature to a lesser degree, showed significant positive weak to moderately strong association with plant trait richness and evenness across all plot sizes. We also detected multiple highly significant but weak effects of geodiversity components on trait diversity dimensions. Some notable exceptions include moderate negative effects of soil silt heterogeneity on trait divergence across 1000 m2 plots and positive and weak negative effects of TWI and soil sand heterogeneity on trait evenness, respectively. Explained variance was low across models, but higher for models from 1000 m2 vegetation plots. Evidence for the indirect effects of geodiversity on trait diversity was extremely weak.Main ConclusionsOur findings suggest variable‐specific effects of geodiversity on trait diversity, with significant effects of multiple geodiversity components but dominated by topographic heterogeneity. Importantly, data precision is limited, and we are thus trying to detect signal amongst high noise. Hence, the significant but weak signals we detect may indicate more important underlying patterns than our effect sizes suggest.
Incidence and influencing factors for respiratory sarcopenia in older adults: The first longitudinal evidence from the CHARLS
Authors: Chen Kangkang , Chen Qifeng , Xu Laichao 
Published: August 2024

AimRespiratory sarcopenia (RS) has been newly defined in a position paper by four professional organizations in Japan, and it is necessary to examine its incidence and influencing factors using this new definition. So far, little work has been undertaken; we therefore conducted a longitudinal study to fill this gap.MethodsOur data were extracted from the China Health and Retirement Longitudinal Study. A total of 4301 older adults with complete data and without RS were chosen in 2011, of whom 3065 were followed up until 2015. The presence of low respiratory muscle strength plus low appendicular skeletal muscles mass was defined as RS based on t. A logistic regression model was used to identify the influencing factors for incident RS.ResultsAfter an average of 4 years of follow‐up, the cumulative incidence of RS was 5.2%, and it was particularly high in participants aged >80 (20.9%). Logistic regression analysis showed that being unmarried/divorced/widowed (odds ratio [OR] = 1.85, 95% confidence interval [CI] = 1.28–2.66, P = 0.001), not having dyslipidemia (OR = 0.35, 95% CI = 0.19–0.65, P = 0.001), having digestive disease (OR = 1.56, 95% CI = 1.11–2.19, P = 0.010), asthma (OR = 2.77, 95% CI = 1.55–4.94, P = 0.001), edentulism (OR = 1.73, 95% CI = 1.24–2.42, P = 0.001), low handgrip strength (OR = 2.82, 95% CI = 1.99–3.99, P < 0.001), or low 5‐m gait speed (OR = 1.92, 95% CI = 1.23–3.01, P = 0.004) were associated with a greater likelihood of developing RS. After further adjustment for age and body mass index, asthma, edentulism, and low handgrip strength remained significant.ConclusionsThe identification and management of older adults with the influencing factors described above could be important in preventing RS. Geriatr Gerontol Int 2024; ••: ••–••.
Recent Advances in the Compositional and Mapping Analysis of Iron Meteorites Using a Handheld Laser‐Induced Breakdown Spectroscopy Instrument
Authors: Senesi Giorgio S. , De Pascale Olga , Mattiello Sara , Moggi Cecchi Vanni , Ibhi Abderrahmane , Ouknine Lahcen , Nachit Hassan 
Published: August 2024

Analytical techniques are essential in investigating the unique features of extra‐terrestrial geomaterials, and the use of in situ analytical tools is becoming increasingly common, as it facilitates a quick initial bulk chemical analysis, identification and classification. In this work, a handheld laser‐induced breakdown spectroscopy (hLIBS) instrument has been used to identify the qualitative and quantitative composition, and generate compositional micro‐maps, of a suite of iron meteorite samples representative of the different chemical and structural classes by analysing the spectra released from the plasma formed by the laser impact. Furthermore, the analytical performance of hLIBS was compared with that of portable X‐ray fluorescence spectrometry (pXRF). The analytical precision and accuracy of the calibration curves previously built in the laboratory for a set of certified reference metal alloys was assessed, so that the same protocol could be used to measure those of the investigated iron meteorites. A good agreement was achieved between hLIBS and reference data in the quantitative estimate of the elements Fe, Ni, Co and Cu. An attempt to quantify Ga by LIBS in two classified iron meteorites was also successful.
The Effect of Social Support on Consumers' Variety Seeking
Authors: Cai Yuanyuan , Xu Lisha , Zhang Ke 
Published: August 2024

ABSTRACTSocial support is paramount to people's well‐being. Yet little is known about how such support influences individuals' consumption decisions in retail contexts. This multi‐method research featured five quantitative studies and showed that receiving social support can reduce consumers' variety seeking in subsequent consumption situations. Specifically, Studies 1A and 1B employed secondary data analysis, consistently revealing a negative association between social support and variety seeking. Studies 2–4 adopted experimentation approaches. Study 2 (N = 125) confirmed the proposed effect by experimentally manipulating social support. Study 3 (N = 299) shed light on the underlying mechanism by presenting a mediation model (i.e., social support → increased sense of satisfaction → decreased variety seeking). Besides, Studies 3 (N = 299) and 4 (N = 288) identified two moderators (i.e., individuals' trait gratitude and the chance to pay it forward) of the proposed effect.
Exploring the Impact of Mobile App Quality on consumers' Online Intention to Transact
Authors: Xie Lishan , Zhu Tengteng , Liu Shuying , Huan Tzung‐Cheng 
Published: August 2024

ABSTRACTThis study constructed a research framework for exploring the relationship between the three dimensions of app quality (system quality, information quality, and service quality), flow experience, brand trust, and intention to transact based on the business‐to‐consumer e‐commerce platform. The proposed model was tested by analyzing questionnaire survey data from a sample of 503 consumers with experience of mobile online shopping using the variance‐based structural equation modeling technique. The results showed that all three dimensions of app quality were positively associated with flow experience and brand trust. Flow experience was positively associated with intention to transact. The effect of brand trust on consumers' intention to transact was greater than that of flow experience, suggesting that when shopping on a mobile app platform, consumers may be more concerned about trusting the brand than about pleasure in making a purchase decision. The results enrich business‐to‐consumer e‐commerce theory and provide meaningful managerial implications.
Addressing residue and resistance in food animals: a policy imperative in Southeast Asia
Authors: Sundram Pushpanathan , Lloyd Charmaine , Eri Rajaraman 
Published: August 2024

SummaryResidue and resistance in food animals pose significant challenges to Southeast Asia's public health, animal welfare, agricultural productivity, and sustainability. This article emphasises the need for policy interventions to address these issues effectively. Residue, the presence of harmful substances in animal products, is a concern due to the misuse of veterinary drugs and pesticides. Robust surveillance programs, risk assessment, and enforcement of maximum residue limits are crucial to ensure food safety. Antimicrobial resistance (AMR) is another critical challenge in the region, driven by intensive animal production systems and disproportionate antimicrobial use. Responsible antimicrobial use, surveillance systems, and alternative production practices like vaccination, enhanced animal husbandry, and improved biosecurity a re essential to combat the menace. Addressing residue and resistance requires a comprehensive mindset and policy approach, including strengthening regulatory frameworks and inter‐agency collaboration, including a One Health approach. Governments, farms, veterinarians, and other stakeholders must work together to develop and enforce effective policies. Education and awareness campaigns can promote responsible practices throughout the food‐animal production chain. By prioritising the reduction of residue and resistance, Southeast Asian countries can safeguard public health, ensure sustainable agriculture, and contribute to global efforts in tackling AMR. Policymakers supported by academia, industry, and other stakeholders play a crucial role in effectively shaping and implementing policies to address these challenges.
Lipidomics unveils changes in oxidised lipids in human breast milk by high‐pressure processing
Authors: Medina‐Meza I. G. , Balasubramaniam V.M. , Kaven M. , da Silva A. Gomes , Guduru Sai Sashidhar 
Published: August 2024

SummaryHuman breast milk is a complex fluid rich in bioactive molecules crucial for infant growth and development. Global health organisations recommend exclusive breastfeeding to optimise infant health. In cases where maternal milk is unavailable, donor breast milk from human milk banks (HMBs) serves as an essential alternative. Currently, human breast milk preservation relies on Holder pasteurisation (HoP), which, while effective at pathogen inactivation, can compromise breast milk's nutritional and biological properties. High‐pressure processing (HPP) is an alternative pasteurisation method that utilises high pressure to kill pathogens without degrading nutrition. This study examined HPP's impact on donor breast milk lipids, sugars and antioxidants. Metabolomics reveals diverse bioactive compounds, including lipids, polyphenols and polyketides, elucidating breast milk's complexity. Some lipid subclasses respond to HPP; ceramides decreased under both treatments, while fatty aldehydes and esters increased under specific HPP conditions. Additionally, we quantified oxidised lipids, notably dietary oxysterols (DOxS), known for pro‐oxidant and pro‐inflammatory properties. These findings enhance understanding of HPP targeted approaches and breast milk's complexity, contributing to innovative milk preservation techniques that could advance specialised infant nutrition and assist donor milk banking systems.
Improving undergraduate education in immunology through assessment of interdisciplinary scientific knowledge
Authors: Baty Joshua J , Patel Isha , Taylor Jared P , Graben Connor , Deaver Jill , Justement Louis B , Bruns Heather A 
Published: August 2024

AbstractThe interdisciplinary nature of immunology can make studying not only engaging but also challenging, as understanding immunologic processes and immune system components requires foundational knowledge from several science disciplines. The University of Alabama at Birmingham has a unique, 4‐year, Undergraduate Immunology Program (UIP) that provides a comprehensive curriculum in immunology that includes five core courses starting in the second year, at which point, students are in the process of completing basic science sequences. For this study, students in courses across the UIP curriculum were asked to identify basic science topics that relate to four immunology concepts. In addition, students were surveyed on their confidence in understanding each of the basic science topics and were asked to identify the course in which they felt that they had fully learned the topic. Data from this study did not demonstrate a change in students’ interdisciplinary science competency from the second to fourth year. Importantly, students reported that they fully understood 11 out of 12 basic science concepts in courses offered in their first and second years, with confidence in basic science topics significantly improving from the second to third year. The lack of demonstrated improvement in interdisciplinary understanding across the curriculum may be attributed to the fact that students are able to integrate basic science topics with foundational immunologic concepts as early as their second year. Importantly, these findings suggest that the integration or review of basic science topics in an immunology course may improve students’ comprehension of foundational immunology concepts and interdisciplinary science competency.
Structure, bond features, and microwave dielectric properties of Li2(Mg1−xCax)2(MoO4)3 ceramics for ULTCC application
Authors: Duan Shumin , Qing Zhenjun , Liu An , Li Haiyan , Xue Yan 
Published: August 2024

AbstractUltra‐low temperature sintered ceramics, Li2(Mg1−xCax)2(MoO4)3 (x = 0.025–0.100), were synthesized using the solid‐phase method. XRD analysis revealed that adding Ca2+ increased the second‐phase CaMoO4 content. Particularly, Li2(Mg0.975Ca0.025)2(MoO4)3 ceramics exhibited excellent properties: εr = 9.31, Q × f = 55,400 GHz, and τf = −38.9 ppm/°C. Incorporating Ca2+ significantly improved the performance of ceramics. The microwave dielectric properties of Li2(Mg0.9Ca0.1)2(MoO4)3 ceramics sintered at 650°C showed enhancements: εr of 9.55, Q × f of 63,500 GHz, and τf of −10.8 ppm/°C. The rise in εr can be attributed to polarizability, while a higher packing fraction led to a larger Q × f value, and the reduced distortion of the [Li/Mg/CaO6] octahedra enhanced the τf value. Moreover, the increased of CaMoO4 also positively influenced the ceramic's properties. Furthermore, in accordance with the principles of complex chemical bonding, the elevation of ionicity, lattice energy, and bond energy of the Mo–O bond contributed to the enhancement of εr, Q × f, and τf, respectively. Raman spectroscopy showed a positive correlation between dielectric loss and full width at half maximum of the Raman peak. Good chemical compatibility between silver and Li2(Mg0.9Ca0.1)2(MoO4)3 ceramic was demonstrated through our co‐firing experiment.
The influence of point defects on the sintering of magnesium oxide
Authors: Halabi Rawan , Simotko Sasha , Tsur Yoed 
Published: August 2024

AbstractIn this study, the influence of foreign and native point defects in magnesium oxide on the sintering process is examined. We have introduced dopants into magnesium oxide, with cations that share similar sizes but possess varying charges to minimize the direct impact of strain. The selected foreign cations were as follows: (1) Li1+, an acceptor that enhances the concentration of oxygen vacancies; (2) Sc3+, a donor that enhances the concentration of magnesium (metal) vacancies; and (3) Zn2+, an isovalent dopant. The results reveal that oxygen vacancies introduced by lithium doping greatly decrease the sintering temperature of magnesium oxide compared to the magnesium vacancies’ effect (scandium doping). Zinc doping was found to increase the surface oxygen vacancies with only a minor effect on the sintering temperature. Enhancing the oxygen vacancy concentration by lithium doping creates an additional mechanism for sintering because the anion sublattice is the backbone of the material, and oxygen ion diffusion is the rate‐limiting step. Scandium doping also has a sintering–promoting effect, yet a minor one. The doping factor analysis is considered and implies that aliovalent dopants do not affect the concentration of the fast‐diffusing species, which are native vacancy associates.
Dissolution kinetics of cementitious magnesium silicate hydrate in air‐equilibrated water
Authors: Wahab Abdul , Nguyen Trinh Thao My , Singh Dylan , La Plante Erika 
Published: August 2024

AbstractMagnesium silicate hydrate (M‐S‐H) represents a promising alternative to traditional cement, particularly for low‐pH construction applications such as nuclear waste encapsulation and carbon dioxide injection. The durability of construction materials, a critical aspect of their suitability for various purposes, is primarily governed by the kinetics of dissolution of the binder phase under service conditions. In this study, we employed in situ atomic force microscopy to assess the dissolution rates of M‐S‐H in water equilibrated with air. Quantitative analysis based on changes in volume and height revealed dissolution rates ranging from 0.18 to 3.09 × 10−12 mol/cm2/s depending on the precipitate Mg/Si ratio and morphology. This rate surpasses its crystalline analogs, talc (Mg3Si4O10(OH)2) and serpentine (Mg3(Si2O5)(OH)4), by about three to five orders of magnitude. Interestingly, oriented M‐S‐H dissolved faster than non‐oriented M‐S‐H. Spatially resolved assessments of dissolution rates facilitated a direct correlation between rates and morphology, showing that edges and smaller crystallites dissolve at a faster pace compared to facets and larger crystallites. The outcomes of this study provide insights into the mechanisms governing the dissolution of M‐S‐H and the factors dictating its durability. These findings hold implications for the strategic design and optimization of M‐S‐H for various applications.
Correlation of psychological resilience with social support and coping style in Parkinson's disease: A cross‐sectional study
Authors: Yang Mengshu , Xue Jingyuan , Kong Xiaoyun , Liu Wenjing , Wang Yihao , Zou Yanwei , Wang Ling , Dong Ci 
Published: August 2024

AbstractAimsTo analyse the current status of psychological resilience in Parkinson's disease (PD) patients and its correlation with social support and coping style.DesignA cross‐sectional study.MethodsPD patients hospitalized in a tertiary‐level hospital in Shijiazhuang, Hebei Province, from March 2022 to March 2023 were selected for the study using the convenience sampling method. A general information questionnaire, psychological resilience scale, Medical Coping Modes Questionnaire and Perceived Social Support Scale were used to investigate 111 cases of PD. SPSS 25.0 software was used for statistical analysis. The data were analysed using independent samples t‐test, one‐way ANOVA, multiple linear regression analysis and the Pearson correlation coefficient.ResultsParkinson's disease patients have a moderate level of psychological resilience. The results of the Pearson correlation analyses showed that the level of psychological resilience was positively correlated with social support and confrontation and was negatively correlated with avoidance and acceptance‐resignation. The results of multiple linear regression analysis showed that social support and acceptance‐resignation were the influencing factors of psychological resilience in PD patients.ConclusionThe psychological resilience of PD patients is at a moderate level. Social support and acceptance‐resignation are the factors influencing the psychological resilience of PD patients.Impact StatementThis study analysed the level of psychological resilience in PD patients and its correlation with social support and coping style from the perspective of positive psychology to provide some reference for targeted clinical interventions. Our study found that social support and acceptance‐resignation are influential factors in psychological resilience in PD patients. Medical staff should encourage patients to face the disease positively and their social support should be increased in order to improve their level of psychological resilience.Patient or Public ContributionNo patient or public contribution.