bluuebunny/crossref_metadata_2025_split huggingface dataset:
Authors: Lubis Lailatul Husna , Harefa Faradilla Firdani , Sibuea Christofel Haposan , Ginting Mira Hestina 
Published: June 2024

An earthquake with a magnitude of Mw 5.8 rocked the North Tapanuli region on October 1 2022 (02:28:43 WIB) in the Renun segment caused by (right-lateral strike slip). The main earthquake data and the parameters of the source mechanism were obtained from Global CMT and aftershock data were obtained from the BMKG catalog with a range of study locations at 1.60⁰ – 2.52⁰ North Latitude and 98.55⁰ East Longitude – 99.50⁰ East Longitude. The method used is the Coulomb Stress method using Coulomb 3.4 software. The results of the analysis of changes in coulomb stress are areas where there is an increase in stress of 0 to 0.2 bar and a decrease in stress of 0 to -0.2 bar. Areas that have increased stress are in the southwest, southeast, northwest and northeast. While the areas that experienced a decrease in stress were in the east, north, west and south.
Authors: Khodijah Siti , Umiati Ngurah Ayu Ketut , Arianto Fajar 
Published: June 2024

Simulation of HPGe and CsI(Tl) detectors have been carried out by using the MCNP program. This study aims to determine the efficiency of the detector that occurs in conditions of distance and the use of housing materials. Simulation is done by making detector geometry, source definition and pulse count model. The detector geometry is made by modifying the aluminum and stainless steel housing. The emitted gamma radiation comes from a point source of Cs-137 rays. Radiation irradiation to the detector in the direction of the x-axis with a variation of 0.75 to 3.75 cm. . The output of the MCNP program is to display the count value for each predetermined energy bin and the error value of each. The simulation results show that the use of housing of the detector and the distance of the source affect the enumeration. The best efficiency values for the HPGe and CsI(Tl) detectors are and of the aluminium housing. The results of simulation show results that are in accordance with the theory.

Key words: HPGe, CsI(Tl), efficiency, aluminium, stainless steel.
The Distribution of Junior High School Students’ Language Awareness Across English Oral Proficiency and Oral Corrective Feedback Preference
Authors: Prakoso Ananda Rival , Munir Ahmad , Mustofa Ali 
Published: June 2024

Language awareness is crucial in langage learning. It entails how language is perceived and used by the students. Language awareness cannot be separated from teaching learning process since there are many interactions between teacher and students in the class including performing oral competency, learning from mistake, giving and taking oral corrective feedback. Thus, it stil uncovered yet that language awareness is really matter in junior high school. This research tried to investigate the level of language awareness of junior high school students across their oral proficiency level. The study also aims to find out whether students' level of language awareness is significantly different or not in their English oral language proficiency. In addition, the study also arried out to find out students type preference in receiving oral corrective feedback based on their language awareness level. This research is quantitative in nature. The data was collected from teacher archive in the form of students score and questionnaire. Then, the data was analyzed with the help of SPSS 20. The result showed that from 92 junior high school participant 35% of participants are in low level of language awareness; 32% in moderate level and 31% in high level. Based on the result, it can be concluded that majority of junior high school student are in low level of language awareness followed by moderate, and high. The analysis also showed that it retains the hypothesis of students’ language awareness level is similar across different English oral proficiency. Student with low, moderate, and high proficiency shows relatively similar level of language awareness level. Thus, the majority of students prefer explicit correction for oral corrective feedback type.
Fire Safety Status and Evacuation of Medical Facility Considering Elevated Oxygen Concentrations
Authors: Sheikh Mohsin Ali , Karim Rehmat , Daniel Nashiru Mumuni , Khan Mujeeb Ali 
Published: June 2024

Abstract

The prevalence of infectious diseases and rapid population expansion has increased the number of medical facilities. Due to the patients' limited mobility, these hospitals are more susceptible to fire disasters. Both Pathfinder and Fire Dynamic simulators were used to calculate the required safe evacuation time (RSET), heat release rate, visibility, temperature, CO, and oxygen effects on temperature, and available safe evacuation time (ASET). The safety egress of the medical hospital was then evaluated by comparing the available safe evacuation time (ASET) and required safe evacuation time (RSET). The simulation findings showed that the egress guides depend on delay time when delay time increases the egress guides drop. We also studied the importance of egress route decisions and suggested that at least 20 to 30 egress guides be on duty in the medical facility. The safety criteria for the medical facility have been proposed based on the delay time with the normalized egress guides. The high oxygen concentration in a hospital can put the medical staff and patients in danger and limit the required safe egress time to less than 150s. The proposed measures can be used to assess the evacuation safety of a typical medical hospital in use relatively quickly and efficiently
Survey and Distribution of Plant Parasitic Nematodes Infecting Tomato (Lycopersicon esculentum) in Jhansi, (India)
Authors: Sengar Manvendra Singh , Sachan Abha , Pandey Rajesh K , Kumar Shailendra , Kashyap Neelam 
Published: June 2024

Abstract

Tomato (Lycopersicon esculentum) is an important high-value vegetable crop and acts as a natural medicine that alleviates the risk of a condition such as cancer and cardiovascular disease. Plant parasitic nematodes are obligate biotrophic feeders that cause the most devastating phytoeconomic damage to tomato cultivation across the globe. Their infection may lead to a spectrum of disorders like stunting, necrosis, and wilting followed by lessening production. The present investigation embraces an extensive survey work (from October to December 2021) of three tomato crop production sites at Baruasagar in Jhansi and throws light on the occurrence, distribution, and genera diversity of parasitic nematodes in soil and root samples. The morphological identification of six genera Meloidogyne, Pratylenchus, Hoplolaimus, Helicotylenchus, Rotylenchulus,and Criconema was also undertaken in the study. The Root-knot nematodes (Meloidogyne genus) and lesion nematodes (Pratylenchus genus) were the most abundant PPNs in tomato crops. The study also highlighted the varying physicochemical properties of soil played a significant role in the abundance of nematode genera.
Design Modelling and Simulation of Roundabout in Selected Intersection of Urban Road as Per IRC Guidelines and Recommendations
Authors: L Gunashree K , G Anusha , Nagaveni  , Vishwas J S 
Published: June 2024

Abstract

Intersections are the major part of road networks as they connect various parts of the city situated in different directions. Designing the intersections plays a vital role in the development of roadways specially in urban areas. This paper mainly concentrates on designing the selected intersection by designing it as a Roundabout using IRC guidelines. In reference to the 2D model of the existing intersection, a 3D model of the designed roundabout for the study area is done using Auto CAD software. The traffic capacity of the designed roundabout is determined by using highest peak hour traffic count. In order to ensure pedestrian safety, a pedestrian delay time survey is conducted and the average pedestrian delay time is determined. As per the designed roundabout, a software modelling is done using the PTV VISSIM student version and traffic simulation is carried out.
Plant-based food supply requires transformation to fulfil micronutrient needs in China
Authors: Werf Wopke van der , Li Yijun , Gerdessen Johanna C. , Stomph Tjeerd Jan , Kuijsten Anneleen , de Leeuw Sander , Chang Zhiyao , Fan Shenggen , Cong Wen-Feng 
Published: June 2024

Abstract

Plant-based foods can supply most of the required dietary nutrients globally, but weaknesses in nutrition security persist. Here, we assess the role of plant-based food supply (PFS) in fulfilling dietary needs for energy and 17 nutrients in China from 1997 to 2016. We estimate per nutrient the coverage (supply/demand) and source diversity (exponentiated Shannon entropy of sources). Coverage was insufficient (supply/demand<1) for selenium, calcium, riboflavin, and vitamin A. Source diversity was below 4 for vitamins A and C. From 1997 to 2016, coverage and source diversity improved little for these nutrients. Transformations like reducing avoidable nutrient losses, repurposing feed to food consumption via reducing red meat intake, and reallocating domestic crop use increased coverage by at least 18%, but hardly improved source diversity. The above PFS transformations enable the fulfilment of all nutrient needs except selenium, providing opportunities for more sustainable and healthy diets in China.
High MICAL-L2 promotes cancer progression and drug resistance of renal clear cell carcinoma cell via stabilization of ACTN4 and following vimentin expression
Authors: Du Jun , Zhao Weizhen , Qi Chenxiang , Mao Yixin , Ye Fengwen , Xia Tianxiang , Zhao MingYu , Min Pengxiang , Zhang Yujie , Du Jun 
Published: June 2024

Abstract

Kidney clear cell carcinoma (KIRC) continues to be a substantial contributor to cancer-associated fatalities nowadays. Targeted therapies persist as the conventional method of KIRC treatment. Nevertheless, the development of resistance to those drug emerges as a significant impediment to renal cancer management. MICALL2, a member of the molecules that interact with the CasL family (MICALs), plays pivotal roles in cytoskeleton rearrangement. This study sought to elucidate the clinical relevance of MICAL-L2 in KIRC and its regulatory mechanism in cancer progression and resistance to therapy. The Cancer Genome Atlas data mining was utilized to assess the expression of MICAL-L2 in KIRC tissues. Statistical analysis of immunohistochemistry and the Kaplan–Meier Plotter database were employed to investigate the clinical significance of MICALL2. A series of in vitro experiments, encompassing assays for CCK-8, EDU staining, wound healing and transwell migration, flow cytometry, RT-PCR, co-immunoprecipitation analysis were conducted to demonstrate the effects of MICAL-L2 on the drug sensitivity of KIRC cells and to elucidate the underlying molecular mechanisms. MICAL-L2 is overexpressed in KIRC tissues. Elevated MICAL-L2 levels correlate with reduced survival rate and a diminished response to drug therapy in KIRC patients. MICAL-L2 overexpression stimulates cell proliferation, migration and renders KIRC cells insensitive to Sunitinib and Everolimus, two traditional therapeutics for KIRC. Furthermore, MICAL-L2 promotes progression and resistance to therapy in KIRC cells by interacting with its downstream regulator Alpha-actinin-4 (ACTN4) in a Rab13-dependent manner, then reducing ACTN4 degradation, and thereby leading to augmented vimentin expression in KIRC cells. These findings indicate that MICAL-L2 plays a critical role in the progression of KIRC and suggest that MICAL-L2 may function as a therapeutic target in KIRC patients.
Examining emotions in English and translated Chinese children’s literature: a bilingual emotion detection model based on LLMs
Authors: Liu Yanjin , Lee Sophia Yat Mei , Li Dechao 
Published: June 2024

Abstract

The study of emotions within the language sciences has been an area of scholarly interest since the 1880s. Emotion analysis in this field primarily examines the expression of emotions in various texts, encompassing a broad spectrum from online commentary to classical literature. Recent years have seen an increased emphasis on the detection and analysis of emotions within children's literature. This burgeoning interest is motivated by the recognition that a deeper understanding of the emotional layers embedded in children's stories can greatly enhance the insights of educators and caregivers into the emotional development and experiences conveyed through these narratives. While the majority of research in this field has concentrated on the analysis of emotion in monolingual datasets, efforts to explore emotion within bilingual contexts, such as in translated children’s literature, are relatively rare. To address this gap, this paper firstly compiles a bilingual Chinese-English dataset of emotions from a parallel Chinese-English classical children’s literature corpus. Then, the dataset is fine-tuned and evaluated on different Large Language Models (LLMs). The fine-tuning results indicate that the GPT-3.5-turbo model surpasses other language models, reaching its best performance with an F1 of 0.869. This performance denotes not only the feasibility of Chinese-English bilingual emotion detection, but also the applicability of this modelled dataset for future Chinese-English emotion detection tasks.
Bidirectional relationship between epigenetic age and brain health events
Authors: Rivier Cyprien , Szejko Natalia , Renedo Daniela , Clocchiatti-tuozzo Santiago , Huo Shufan , de Havenon Adam , Zhao Hongyu , Gill Thomas , Sheth Kevin , Falcone Guido 
Published: June 2024

Abstract

Chronological age offers an imperfect estimate of the molecular changes that occur with aging. Epigenetic age, which is derived from DNA methylation data, provides a more nuanced representation of aging-related biological processes. This study examines the bidirectional relationship between epigenetic age and the occurrence of brain health events (stroke, dementia, and late-life depression). Using data from the Health and Retirement Study, we analyzed blood samples from over 4,000 participants to determine how epigenetic age relates to past and future brain health events. Study participants with a prior brain health event prior to blood collection were 4% epigenetically older (beta 0.04, SE 0.01), suggesting that these conditions are associated with faster aging than that captured by chronological age. Furthermore, a one standard deviation increase in epigenetic age was associated with 70% higher odds of experiencing a brain health event in the next four years after blood collection (OR 1.70, 95%CI 1.16-2.50), indicating that epigenetic age is not just a consequence but also a predictor of poor brain health. Both results were replicated through Mendelian Randomization analyses, supporting their causal nature. Our findings support the utilization of epigenetic age as a useful biomarker to evaluate the role of interventions aimed at preventing and promoting recovery after a brain health event.
Urban development growth strategies and societal well-being
Authors: Rios-Ocampo Juan , Gary Michael 
Published: June 2024

Abstract

Cities have advanced in terms of economic and social status over the last five decades, improving the living conditions of hundreds of millions of people. However, population growth and urban expansion have put pressure on social and environmental conditions. This study examines the relationship between urban development and societal well-being over time. We analyze 500 pages from published urban plans of Greater Sydney between 1968 and 2018 and code the text into causal maps. The findings show that policymakers adopted a dominant urban development strategy over the last fifty years to pursue economic and public infrastructure growth. This growth strategy resulted in unintended, negative consequences for social and environmental dimensions of societal well-being. Although policymakers eventually recognized the seriousness of these social and environmental consequences, they never attempted to fundamentally change the dominant growth strategy. Instead, policymakers sought to address the consequences (i.e., symptoms) by responding to each issue piecemeal.
Social Determinants of Health as Primary Risk Factors of Hypertensive Disorders of Pregnancy: A Retrospective Cohort Study
Authors: Goedecke Patricia , Nakahara Angela , Pope Spencer , Madlock-Brown Charisse , Sen Saunak , Singarella Irma , Mari Giancarlo , Mockus Audris 
Published: June 2024

Abstract

Public health researchers have raised the question of whether social determinants of health (SDOH) are a primary risk driver for hypertensive disorders of pregnancy (HDP), as opposed to clinical factors including race risk. This retrospective cohort study was performed using known demographic and geospatial risk factors to clarify effects of SDOH on HDP to create performance models comparing SDOH with clinical factors including race risk. Of 5156 pregnancies identified, 7.8% were affected by HDP. 54 factors were compared for their ability to distinguish HDP pregnancies; the top six were aspects of housing. In multivariable logistic models, SDOH demonstrated better model performance (66.1%) than clinical factors and race risk combined (63.0%) as measured by area under receiver operator curve (AUROC). The three categories together demonstrated 71.4% model performance. These models suggest that some incidence of HDP currently predicted by clinical factors including race risk may be better explained by SDOH.
B cells modulate lung antiviral inflammatory responses via the
neurotransmitter acetylcholine
Authors: Baumgarth Nicole , Prieto Antonio Cembellin , Luo Zheng , Kulaga Heather 
Published: June 2024

Abstract

The rapid onset of innate immune defenses is critical for early control of viral replication in an infected host, yet it can also lead to irreversible tissue damage, especially in the respiratory tract. Intricate regulatory mechanisms must exist that modulate inflammation, while controlling the infection. Here, B cells expressing choline acetyl transferase (ChAT), an enzyme required for production of the metabolite and neurotransmitter acetylcholine (ACh) are identified as such regulators of the immediate early response to influenza A virus. Lung tissue ChAT + B cells are shown to interact with a7 nicotinic Ach receptor-expressing lung interstitial macrophages in mice within 24h of infection to control their production of TNFa, shifting the balance towards reduced inflammation at the cost of enhanced viral replication. Thus, innate-stimulated B cells are key participants of an immediate-early regulatory cascade that controls lung tissue damage after viral infection.
Dualism of intraplate and subduction-related volcanism in the Palaeozoic of the Rhenish Massif (Central Europe) and its plate tectonic relevance
Authors: Nesbor Heinz-Dieter 
Published: June 2024

Abstract

Palaeozoic volcanic rocks are widely distributed within the sedimentary rock sequence of the Rhenish Massif. A total of 185 new geochemical analyses of these have been evaluated, allowing a distinction based on indicative trace elements and rare earth elements between intraplate volcanism and subduction-related volcanism. The latter began in the Silurian and continued through the entire Devonian and likely into the early Carboniferous. The trigger for the volcanic activities was the subduction of the Rheic Ocean northward beneath the southern margin of Avalonia. A magmatic arc had developed above the subduction zone, where explosive eruptions occurred throughout the entire timespan. To the north the Rhenohercynian back-arc basin opened from the Lower Devonian onwards, whereby Avalonia was spited into a northern and a southern part. As a result of the increasing rifting of the thinned continental crust of the southern Avalonian shelf area, intense bimodal intraplate volcanism began in the Givetian, parallel to the subduction-related volcanism, persisting until the early Frasnian. The first volcanic cycle ended, after a long interruption in the deeper Upper Devonian, with the eruption of primitive basaltic magma in the highest Famennian. Due to the retreat of the subduction zone (roll back), Southern Avalonia migrated increasingly southward with simultaneous expansion of the back-arc basin. A new volcanic cycle began in the Early Carboniferous, which is characterized by an evolution from tholeiitic to alkaline basaltic magma. The products of both volcanic cycles occupy large areas in the Lahn-Dill region, the Kellerwald, and the Waldeck region. Subvolcanic intrusions and feeder dykes in the Northern Taunus and Sauerland evidence the widespread distribution of volcanism beyond the present-day limits imposed by erosion.
A Cross-sectional and Longitudinal Evaluation of Serum Creatinine as a Biomarker in Spinal Muscular Atrophy
Authors: Zhao Xin , Gong Zhenxiang , Luo Han , Li Zehui , Gao Rong , Yang Kangqin , Deng Wenhua , Peng Sirui , Ba Li , Liu Yang , Zhang Min 
Published: June 2024

Abstract

Objective
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease characterized by proximal muscle weakness and atrophy. The proliferation of disease-modifying therapy has prompted the development of biomarkers to facilitate clinical observations. We explored the association between disease severity and serum creatinine (Crn) levels in patients with SMA over an up to 2-year treatment period with nusinersen.
Methods
We measured serum Crn and assessed function performance using Hammersmith Functional Motor Scale-Expanded (HFMSE), Medical Research Council Scale (MRC), 6-Minute Walk Test (6MWT), ulnar Compound Muscle Action Potential (CMAP) and forced vital capacity (FVC) in a cohort of 28 adolescent and adult patients with SMA. We investigated the association between Crn and disease severity by partial rank correlation and linear mixed model after correction for age, gender, and BMI. The prediction of functional performance was analyzed using linear models.
Results
28 SMA patients with 185 visits and 28 gender- and age-matched healthy controls (HCs) were included. Compared with HCs, SMA patients had significantly lower Crn values ​​(67.4 ± 14 vs 23.7 ± 14.8 umol/L, p<0.0001). Crn has a positive correlation with HFMSE (p<0.0001, r = 0.884), MRC (p<0.0001, r = 0.827), FVC (p = 0.002, r = 0.730), and ulnar CMAP (p<0.0001, r = 0.807) after correction for age, sex, and BMI. The Crn level in patients with SMN2 copy number ≥ 4 is nearly twice (34.1 ± 3.75 vs 17.2 ± 2.52 umol/L, p = 0.00145) as high as that in patients with SMN2 copy number < 4. The Crn level in the ambulants is more than twice (32 ± 2.33 vs 12.9 ± 2.38 umol/L, p<0.0001) as high as that in the non-ambulants. Crn could explain up to 83.5% of the variance of functional performance of the HFMSE, MRC, and 6MWT, which is significantly higher than that of traditional biomarkers.
Conclusions
These findings suggest that Crn can reflect the disease severity in adolescents and adults with SMA, making it a promising candidate biomarker for SMA.