bluuebunny/crossref_metadata_2025_split huggingface dataset:
VAI TRÒ CỦA APOE ε4 VÀ BIOMARKER TRONG ĐIỀU TRỊ BỆNH ALZHEIMER THEO CƠ CHẾ THAY ĐỔI BỆNH
Authors: Hoàng Mai Phương , Phạm Thắng , Nguyễn Trung Anh , William Mantyh , Nguyen Huong , Nguyễn Thanh Bình , Trần Thị Thanh Hương , Nguyễn Thị Thanh Bình , Lê Thị Ngọc , Nguyễn Thanh Bình 
Published: June 2024

Sa sút trí tuệ là một hội chứng suy giảm chức năng nhận thức kèm theo những thay đổi về hành vi và mất chức năng xã hội. Trong các nguyên nhân gây sa sút trí tuệ, bệnh Alzheimer là nguyên nhân thường gặp nhất, chiếm 60-70%.
Bệnh Alzheimer là bệnh lý thoái hóa thần kinh tiến triển với cơ chế bệnh học đặc trưng bởi sự xuất hiện của các mảng amyloid và đám rối tau. Sự tiến triển của bệnh Alzheimer diễn ra qua ba giai đoạn: lắng đọng mảng amyloid ngoại bào, phosphoryl hóa quá mức protein tau, lắng đọng tau phosphoryl hóa (p-tau) trong neuron. Trong 20 năm qua, đã có nhiều xét nghiệm hình ảnh học và dấu ấn sinh học (biomarker) được nghiên cứu phát triển giúp chẩn đoán sớm và điều trị bệnh. Xét nghiệm giúp đưa ra bằng chứng bệnh học của bệnh Alzheimer kể từ khi chưa có biểu hiện lâm sàng, từ đó giúp chẩn đoán bệnh ở giai đoạn sớm.
Hiện tại, Cục quản lý thực phẩm và dược phẩm Hoa Kỳ (FDA) đã chấp nhận sử dụng 7 loại thuốc trong điều trị bệnh Alzheimer: 5 thuốc điều trị triệu chứng và 2 thuốc điều trị theo cơ chế bệnh sinh. Khi các phương pháp điều trị bệnh Alzheimer theo cơ chế thay đổi bệnh ngày càng được nghiên cứu phát triển, xét nghiệm biomarker ngày càng trở nên quan trọng trong việc xác định các bệnh nhân thuộc đối tượng điều trị. Đặc biệt, sự phát triển của xét nghiệm các biomarker trong huyết thanh (amyloid-β Aβ42/Aβ40, apolipoprotein E) cho phép xét nghiệm nhanh và có thể thực hiện dễ dàng trên bệnh nhân. Trong tương lai, ngày càng có nhiều xét nghiệm biomarker sẽ giúp chẩn đoán sớm, từ đó lựa chọn đối tượng điều trị phù hợp cũng như theo dõi, tiên lượng khi điều trị thuốc theo cơ chế thay đổi bệnh.
EFEKTIVITAS PERMAINAN HALANG RINTANG DALAM MENINGKATKAN KEMAMPUAN MOTORIK KASAR GANGGUAN SPEKTRUM AUTISME
Authors: Taftazani Maulfi Afiffati , Kurniawan Hendri 
Published: June 2024

Autism spectrum disorder (ASD) is a neurodevelopmental disorder which is also characterized by gross motor delays which affect the development of functional abilities. Obstacle games provide sensory input that allows children to coordinate their body parts well. This study aims to determine the effectiveness of obstacle games on gross motor skills in ASD children aged 3-10 years.
Method: Quantitative research using a pre-experiment one group pretest-posttest design. The research sample of 20 people was obtained using a purposive sampling technique. Motor ability variables were measured using the Test of Gross Motor Development-2 (TGMD-2) instrument. Data analysis used a paired t-test and n-gain score test with SPSS 25 software.
Results: The majority of the research samples were male (85%), pre-school age (85%), and were at the average GARS category level (75%). Hypothesis testing showed a p-value = 0.000 (p<0.05) which means there is a significant difference in gross motor skills in children with ASD between before and after the obstacle course game. The N-Gain Score test obtained a value of 0.42, which means it is effective in the medium category.
Conclusion: The obstacle course game is effective in improving the gross motor skills of children with autism spectrum disorders.
Predatory Journals and Afghan University Instructors; The Extent of Usage, Factors and Impact- Acknowledging Authors to Manage Their Publication Process
Authors: ADIB Abdul Rahman , Hakimi Abdul Aziz 
Published: June 2024

Purpose: As specialists having seen that a large number of Afghan authors throw their hard work and efforts into a trash along with an exuberant amount of their money, we conducted this study to find the root causes of predatory publishing among Afghan university instructors.
Methodology: looking at the type of research problem we adopted survey design. We administered a Google Forms survey questionnaire containing both close and open ended questions to which 230 Afghan university instructors responded.
Findings: The results demonstrated that a large number of Afghan university teachers get published in predatory journals for several reasons. These instructors (2.83) heavily relied on their guide teachers’ and colleagues, thus made publications based on their order or recommendation. Others (3.4) had no idea how to spot or what to do to identify predatory journals. Among them some (3.17) were either pushed or compelled themselves to publish perpetually. A number of theses teachers (3.39) knew not about predatory publishing, especially new recruited ones. Others (3.52) found it difficult to distinguish between authentic and predatory journals and a small number of them (3.65) could not afford the publication fees required by high standard, reputable journals.
Theoretical framework: As indicated we first identified themes and then conducted survey to find evidence for accepting or rejecting them. The existing theories were further explored through the study.
Implications: the study opens the gate for further studies and actions needed by practitioners especially calling on officials at the Ministry of Higher Education of Afghanistan to prevent predatory publishing.
Value: Not only will this paper inform policy makers and practitioners to take steps but will also help authors get aware that a work can be invalid and be cautious.
Limitations: This study only provides the extent, impact and reasons of predatory publishing by Afghan authors and beware them of the danger. Therefore, further study, in particular, action study is needed in their own language to help them be able to manage their scholarly publications.
Significados da olimpíada nacional de povos tradicionais, quilombolas e indígenas: um projeto de transformação
Authors: Matiello Ana Claudia Taube , Souza Ana Quezia Lopes , Pereira Lisanil da Conceição Patrocínio 
Published: June 2024

O presente artigo tem como objetivo relatar a experiência das autoras na Olímpiada e Mostra Científica Estadual de Povos Tradicionais, Quilombolas e Indígenas, que acorreram em Cuiabá, na capital do Mato Grosso, e bem como relacionar este evento que expõe argumentações e experiências significativas na aprendizagem de todos os envolvidos, principalmente a Escola Estadual Terra Nova. A olimpíada oferece aprendizados na escrita, oratória e interesse por pesquisar e estudar sobre o trabalho proposto. A Escola Agrícola Terra Nova que participou deste evento foi de suma importância, visto que a mesma e um exemplo da educação no campo e do campo, colaborando na construção de desseseis trabalhos. A metodologia utilizada foi referências bibliográficas, e observação participante, para compreendermos dados primordiais para a elaboração do trabalho. Conclui-se com o artigo que a participação de professores e alunos nesse evento, bem como de voluntários, transforma quem participa, o aprendizado e experiência adquiridos são para a vida toda.
Микроволновая установка с щелевым цилиндрическим резонатором для вытопки жира из мясных отходов
Authors: Воронов Евгений Викторович , Новикова Галина Владимировна , Суслов Сергей Александрович , Михайлова Ольга Валентиновна , Просвирякова Марьяна Валентиновна 
Published: June 2024

По данным Росстата, в 2022 году в России объем выращенного крупного рогатого скота на мясо составил 1673,5 тыс. тонн. После убоя в сутки на мясокомбинатах РФ накапливается 126,3 тонн вторичного мясного сырья, из которых производят кормовую и техническую продукцию. Но при термообработке желудков жвачных животных используют установки с высокими эксплуатационными затратами. Поэтому существует необходимость переработки указанного сырья в кормовую продукцию с использованием энергии электромагнитных излучений сантиметровых волн. Целью исследований является разработка СВЧ-установки с электроприводным щелевым резонатором в экранирующем корпусе для термообработки сырья в непрерывном режиме с реализацией рекуперации электромагнитной мощности в кольцевом объеме, излучаемой системой первичных источников в резонаторе. Исследуемое сырье – слизистые субпродукты жвачных животных. Внутри корпуса установки, с зазором не более 3,06 см от верхнего его основания, где размещены магнетроны, соосно расположен электроприводной цилиндрический щелевой резонатор без верхнего основания, а соосно с ним − керамическая перфорированная воронка. Средний кольцевой объем кратен половине длины волны. Боковая поверхность резонатора представлена как вертикально расположенные стержни со щелями между ними. Установка представлена как соосно расположенные цилиндрический щелевой и коаксиальный резонаторы. Резонатор обеспечивает: возбуждение электромагнитного поля сверхвысокой частоты (ЭМПСВЧ) и концентрацию энергии в сырье за счет керамической воронки; высокую напряженность электрического поля (до 2 кВ/см); рекуперацию мощности потока излучений через щели резонатора; радиогерметичность за счет запредельного волновода; тонкое измельчение сырья в процессе удара о неферромагнитные стержни резонатора. Термообработка сырья происходит производительностью 40–45 кг/ч, при пропускной способности электроприводного щелевого резонатора с керамической перфорированной воронкой 59 кг/ч и удельных энергетических затратах 0,29 кВт∙ч/кг. Экономический эффект составляет 456 246 руб./месяц.
Intensitas Aplikasi PSB (Photosynthetic Bacteria) dan Pemberian Pupuk Daun pada Tanaman Buncis (Phaseolus vulgaris L.)
Authors: Hamidatun Maulana Eni , . Mawardi 
Published: June 2024

Beans are a type of legume that has important nutritional value for healt and has the potential to be developed, both in the lowlands and highlands. Beans contain 2.4 g protein, 0.2 g fat, 7.7 g carbohydrates, as a source of calories and 6.5 g calcium, 4.4 g phosphorus, 1.1 g iron, 630 mg vitamin A, vitamins B1 0.08 mg, vitamin B2 0.01, vitamin B3 0.7 mg, vitamin C 1.90 mg, calories 35 cal and water content 89 grams which greatly affect the quality of public health (Waluyo and Djuriah, 2013). This research was conducted from December 2021 to February 2022, in Pancakarya Village, Ajung District, Jember Regency, East Java. This study used a factorial pattern consisting of two factors with three replications in a randomized block design (RAK). The first factor is type of fertilizer (P) which consists of no fertilizer (P0), NPK fertilizer (P1), and complete fertilizer (P2). The second factor is intensity (I), which consists of PSB once a week (I1) and PSB twice a week (I2). The combination of fertilization consists of PSB Bacterial Culture + NPK Fertilizer and a combination of PSB Bacterial Culture + Complete Fertilizer. The collected data were analyzed by means of variance (Anova), if significantly different, then followed by BNT’s test of 5%. The result showed that the type of fertilizer (P) dan Intensity (I) treatments on the appearance of flowers, number of branches, and fruit weight.
Pengaruh Intensitas dan Konsentrasi GA3 untuk Peningkatan Kualitas Buah Jeruk Siam (Citrus nobilis) Jember
Authors: Dinda Nurisma Megy , FUROIDAH NANIK 
Published: June 2024

This study aims to determine the best intensity and concentration of ZPT GA3 to improve the quality of Siamese oranges. This research was conducted from November 2022 to April 2023, in Pancakarya Village, Ajung District, Jember Regency, East Java Province. This study used a randomized block design (RBD) with a factorial pattern, the first factor was 3 concentration treatments (K) and the second factor 3 intensity treatments (I), repeated 3 times. So that the total experiment is 27 plants. The treatment used was I1 = 1 spraying; I2 = 2 times spraying; I3 = 3 sprays and K1 = 20 ppm concentration; K2 = Concentration 40 ppm; K3 = Concentration 60 ppm. The test was carried out with the F-test with analysis of variance (ANOVA), if there is a significant difference (F-count value > F-table) then proceed with the 5% DMRT test. The results showed that the combination of using intensity 1 time per 2 weeks (I1) with a concentration of 40 ppm GA3 (K2) showed a significant interaction on fruit volume parameters. However, the difference was not significant in fruit weight.
El uso de las redes sociales como herramienta pedagógica en el aula
Authors: Lázaro-Paz Mayra Alexandra , Lázaro-Paz María Cristina , Morán-Cervantes Jesús Alex , Tapia-Bastidas Tatiana 
Published: June 2024

Las redes sociales se han apoderado de muchos procesos que se vinculan con el desarrollo educativo de la sociedad, es por ello necesario que se estudie en profundidad los diversos aspectos que van de la mano de esta herramienta tecnológica, el uso de las redes sociales actualmente facilita la comunicación otro criterio que válida el alcance del trabajo. En el presente estudio, se planteó como objetivo: determinar el impacto del uso de las redes sociales como herramienta pedagógica en el aula en la motivación del aprendizaje de la asignatura de Lengua y Literatura de los estudiantes de séptimo año de educación general básica de la Unidad Educativa Básica Fiscal “Luz de América”. Para ello se llevó a cabo una investigación bajo un enfoque mixto, cuali-cuantitativo, de tipo descriptiva, además se trabajó con los métodos teóricos, el empírico, el estadístico y el bibliográfico, dentro de los cuales se utilizó la entrevista a los docentes. Dentro de los principales resultados se identificó que los docentes conocen del uso de las redes sociales como herramienta pedagógica, por tanto, es fundamental que los estudiantes utilicen este tipo de recursos que ofrece la tecnología actual. Se infiere que con el uso adecuado de este tipo de redes sociales se fortalece y contribuye en el desarrollo pedagógico de los docentes y por ende se logran alcanzar a mejorar en la adquisición de las habilidades y destrezas de los estudiantes en las aulas de clases.
In silico determination of potential miRNAs encoded in wheat genome that target AvrSr35 in Puccinia graminis f. sp. tritici
Authors: Atakan Aydın , Motorcu Hayri Mert , Maraklı Sevgi 
Published: June 2024

Wheat (Triticum aestivum L.) belonging to Poaceae family is a valuable staple food all over the world. Puccinia graminis f. sp. tritici is one of the major limiting factor in wheat production, causing stem rust disease. RNA interference (RNAi) is an effective technique for plant production against abiotic stresses. One of the most investigated RNAi molecules is microRNAs (miRNAs). It is well established that miRNAs play important role for the regulation of gene expression at post-transcriptional and pos-translational level. In the present study, wheat miRNAs-stem rust interactions were investigated by in silico methods. For this purpose, reference mature wheat miRNAs were retrieved from miRBase, and the sequences of avirulence gene (AvrSr35) in Puccinia graminis f. sp. tritici were obtained from NCBI. RNAhybrid algorithm was used to predict the relationships between miRNAs and avirulence gene targets. Moreover, a phylogenetic tree was constructed by using miRNAs via MEGA X. We determined that AvrSr35 gene was targeted by a total of 12 miRNAs including tae-miR9657a-3p, tae-miR9671-5p, tae-miR1122c-3p, tae-miR1130b-3p, tae-miR9678-3p, tae-miR9781, tae-miR9666b-3p, tae-miR531, tae-miR9773, tae-miR9778, tae-miR9677b and tae-miR10516. All miRNAs were separated into three major groups. All miRNAs showed close relationship. The first main group consisted of only tae-miR9778. Obtaining findings are expected to contribute roles of miRNAs in the interaction between disease-related miRNAs in plants and pathogens.
DAMPAK HUKUM PERKAWINAN SIRI
Authors: Cenne Herniati , Iin Hartini Sri , Firmansyah Reliubun Idris 
Published: June 2024

Tujuan perkawinan adalah untuk menciptakan keluarga yang bahagia dan langgeng, suami dan istri harus saling mendukung agar masing-masing dapat tumbuh secara pribadi dan mencapai kesejahteraan materi dan spiritual.
Tujuan kegiatan pengabdian kepada masyarakat ini adalah untuk melaksanakan Tri Dharma Perguruan Tinggi dan membantu menyukseskan progam program pemerintah, menyelesaikan permasalahan serta mencari solusi terhadap permasalahan yang dihadapi masyarakat terkait dengan pernikahan sirri, khsusunya masyarakat kampung Arsopura Distrik Skanto kabupaten Keerom. Metode yang digunakan dalam kegiatan pengabdian ini adalah melakukan pendataan bagi pasangan yang menikah siri; pendampingan dan konsultasi terhadap pasangan yang berdampak dari pernikahan siri serta penyuluhan hukum yang memberikan pemahaman terhadap akibat hukum dari pernikahan siri, pendampingan terhadap pasangan suami-isteri telah melangsungkan perkawinan di bawah tangan. Kesadaran hukum masyarakat tentang pentingnya mencatatakan perkawinan mereka kepada Lembaga yang berwenang mencatat, terwujud masyarakat yang taat hukum serta mengetehaui dampak pernikahan siri. Terciptanya keluarga yang harmonis bahagia lahir dan batin sehat jasmani dan rohani. Terbentuknya keluarga yang kuat dan utuh mempersiapkan masa depan anak-anaknya dengan pendidikan sehingga menjadi manusia pembangunan.
การพัฒนาเกมสถานการณ์จำลองท่องเที่ยววิถีช้าง
Authors: พาสวรรค์ อนุรักษ์ , สุวรรณศรี ไพรสันต์ , สุวรรณศรี พิมพ์ชนก 
Published: June 2024

งานวิจัยนี้มีวัตถุประสงค์ เพื่อพัฒนาเกมสถานการณ์จำลองท่องเที่ยววิถีช้าง กลุ่มตัวอย่างคือนักศึกษามหาวิทยาลัยราชภัฏเชียงใหม่ สาขาคอมพิวเตอร์ศึกษา ชั้นปีที่ 3 จำนวน 20 คน ได้จากการสุ่มอย่างง่าย เครื่องมือที่ใช้ในการพัฒนา ได้แก่ เกมสถานการณ์จำลองท่องเที่ยววิถีช้าง และแบบประเมินความพึงพอใจต่อการใช้งานเกมสถานการณ์จำลองท่องเที่ยววิถีช้าง วิเคราะห์ผลด้วยค่าเฉลี่ย และส่วนเบี่ยงเบนมาตรฐานผลการวิจัยพบว่า ในการพัฒนาเกมด้านกราฟิก ผู้วิจัยได้ออกแบบให้มีความกึ่งเสมือนจริงใช้องค์ประกอบที่มีความสมจริง เช่น ต้นไม้ ภูเขา แม่น้ำ เป็นต้น ผสมกับความเป็นเกมโดยใช้โมเดลที่มีอยู่แล้วภายในโปรแกรม โรบล็อกซ์สตูดิโอที่มีผู้พัฒนาอื่น ๆ สร้างไว้ ส่วนของอนิเมชั่นใช้โปรแกรมเบลนเดอร์ (Blender) ในการสร้าง อนิเมชั่นการขยับของช้าง เช่น การเดิน การแสดงโชว์ของช้าง เป็นต้น พัฒนาเกมด้วยโปรแกรมโรบล็อกสตูดิโอใช้ภาษาเลือ (LUA) เป็นหลักในการพัฒนาระบบภายในเกม การเล่นเกมสถานการณ์จำลองท่องเที่ยววิถีช้าง เป็นเกมที่มีการโหลดข้อมูลที่ใช้ในการแสดงผลเป็นจำนวนมาก จำเป็นอย่างยิ่งที่จะต้องใช้เครื่องคอมพิวเตอร์ หรืออุปกรณ์ที่มีประสิทธิภาพเพื่อการประมวลผลของภาพและเสียงที่สมบูรณ์ ผลการประเมินความพึงพอใจต่อเกมสถานการณ์จำลองท่องเที่ยววิถีช้าง โดยรวมอยู่ในระดับมากที่สุด
Brucellosis: Infectious Disease
Authors: M. Jawad Sahar 
Published: June 2024

Brucellosis is a zoonotic disease caused by Brucella species, a small, Gram-negative coccobacilli group, with four species (B. melitensis, B. abortus, B. canis, and B. suis), causing illness in humans. These bacteria have a different type of outer membrane containing lipopolysaccharides (LPS) compared to similar bacteria like those in the Enterobacteriaceae family. Symptoms typically begin with a sudden fever, and as the illness progresses, it can enter into chronic stage characterized by recurring episodes of fever, along with symptoms such as weakness, sweating, and general discomfort. Human brucellosis is caused by various strains of Brucella bacteria, including B. abortus (from cattle), B. melitensis (from sheep and goats), and B. suis (from hogs). While infections from B. canis (from dogs) are infrequent, they have been reported. Among these, B. melitensis and B. suis tend to be more potent in terms of their pathogenicity. Farm animals, raw dairy products, and wild animals such as deer, bison, horses, moose, caribou, hares, chickens, and desert rats can carry brucellosis, which can also infect humans. In this chapter, we will discuss how brucellosis is contracted and the diseases it can cause. We will focus on Iraq, where brucellosis is a common disease.
Methodology for assessing the competitiveness of an organization
Authors: Ян С. , Сюй Ц. 
Published: June 2024

изучение методических аспектов оценки конкурентоспособности предприятий остаётся весьма значимым в современном предпринимательском мире. Грамотное и исчерпывающее оценивание в данной области позволяет руководству компаний понять своё положение на рынке, выявить сильные, слабые стороны, а также определить потенциальные ориентиры для улучшения позиций относительно конкурентов. В условиях интенсивно трансформирующейся и преобразующейся экономической среды, усиливающейся конкуренции важно постоянно анализировать своё место на рынке, принимать соответствующие стратегические решения – тщательно продуманные и аргументированные. Исследование методики оценки конкурентоспособности в этой связи помогает организациям быть гибкими, адаптивными к изменениям, а также эффективно применять имеющиеся ресурсы. Итак, в нынешних условиях изучение методического инструментария является весьма актуальным – из соображений успешного развития бизнеса в динамичных условиях. В рамках данной статьи автором рассмотрены сущностные аспекты оценивания конкурентоспособности организации. Представлено описание базовых методических направлений, используемых в современных условиях. Новизна исследования заключается в том, что на основе анализа концептуальной базы, теоретических положений предложен авторский алгоритм разработки методики оценки конкурентоспособности субъекта хозяйствования – с опорой на систематизацию отражённых в научных публикациях представлений.
the study of methodological aspects of assessing the competitiveness of enterprises remains very important in the modern business world. A competent and comprehensive assessment in this area allows the management of companies to understand their position in the market, identify strengths and weaknesses, as well as identify potential benchmarks for improving positions relative to competitors. In the conditions of an intensively transforming and transforming economic environment, increasing competition, it is important to constantly analyze your place in the market, make appropriate strategic decisions – carefully thought out and reasoned. The study of the methodology for assessing competitiveness in this regard helps organizations to be flexible, adaptive to changes, as well as effectively use available resources. So, in the current conditions, the study of methodological tools is very relevant – for reasons of successful business development in dynamic conditions. Within the framework of this article, the author considers the essential aspects of assessing the competitiveness of an organization. The description of the basic methodological directions used in modern conditions is presented. The novelty of the research lies in the fact that, based on the analysis of the conceptual framework and theoretical provisions, the author's algorithm for developing a methodology for assessing the competitiveness of a business entity is proposed, based on the systematization of ideas reflected in scientific publications.