bluuebunny/crossref_metadata_2025_split huggingface dataset:
UV/Peroxyacetic Acid Mediated Chlorophenol Congener Degradation
Authors: Sharma Swati , Mukhopadhyay Mausumi , Murthy Zagabathuni Venkata Panchakshari 
Published: February 2013

AbstractThe significance of the chlorine substituent in the remediation of chlorophenol (CP) congeners viz. 4‐chlorophenol (4‐CP), 2,4‐dichlorophenol (2,4‐DCP), 2,4,6‐trichlorophenol (2,4,6‐TCP), and pentachlorophenol (PCP) by organic oxidant, peroxyacetic acid (PAA) coupled with UV irradiation in basic media was investigated. The reactions were followed by high‐pressure LC for residual concentration and GC–MS for mineralization, and reaction product identification. The decrease in chemical oxygen demand was noted to reduce to zero during the observed time span. The decline in chloride content was ascribed to rapid consumption of chloride ions for the formation of acidic degradation products. A decrease in pH reiterated the same. CP congeners were observed to degrade in the order, PCP > 4‐CP > 2,4‐DCP > 2,4,6‐TCP and were best described by first‐order regression fitting. During the remaining time span, the second‐order fitting was in good agreement in the order PCP > 2,4,6‐TCP > 4‐CP > 2,4‐DCP. The degradation efficacy was observed to follow the order 2,4‐DCP > PCP > 4‐CP > 2,4,6‐TCP. The formation of ring cleavage products in 2,4,6‐TCP and PCP degradation was confirmed by GC–MS.
Biological and ecological diversity of aquatic macroinvertebrates in response to hydrological and physicochemical parameters in tropical forest streams of Gunung Tebu, Malaysia: implications for ecohydrological assessment
Authors: Md Rawi Che Salmah , Al‐Shami Salman Abdo , Madrus Madziatul Rosemahanie , Ahmad Abu Hassan 
Published: February 2013

ABSTRACTIn this study, we have investigated the effects of some hydrological and physicochemical parameters such as water quality, velocity, water depth, river width, water pH, water temperature, ammonia‐N, biochemical oxygen demand (BOD), chemical oxygen demand (COD) and dissolved oxygen (DO) on diversity of aquatic macroinvertebrates in forest streams of Gunung Tebu (GT), Malaysia. The results of canonical correspondence analysis identified three groups of the aquatic macroinvertebrates according to their relationships with hydrological and physicochemical parameters. The stream velocity, water quality (i.e. DO, BOD and ammonia‐N) in addition to canopy cover, total habitat score and substrate quality were the determinant factors controlling the diversity pattern of the aquatic macroinvertebrates in GT streams. Alteration in the hydrological and physicochemical parameters showed to influence the ecological diversity of the aquatic macroinvertebrates in GT streams. The predators were found to be highly associated with the elevated concentrations of BOD and COD. Shredders were positively correlated with pH, stream velocity, DO and habitat quality indicators (total habitat score, embeddedness, epifaunal and canopy cover). However, the collector‐gatherers correlated negatively with all of these parameters. It was concluded that stream velocity, substrate structure and water quality were strong attributes for variation in aquatic macroinvertebrate assemblage structure in tropical forest streams of GT. Copyright © 2013 John Wiley & Sons, Ltd.
Alteration of flow regimes caused by large‐scale forest disturbance: a case study from a large watershed in the interior of British Columbia, Canada
Authors: Zhang Mingfang , Wei Xiaohua 
Published: February 2013

ABSTRACTForest disturbance can greatly alter flow regimes and consequently the structures and functions of ecosystems. However, the impacts of forest disturbance on flow regimes have rarely been investigated in large watersheds. In this study, we used a large severely disturbed watershed, the Baker Creek watershed located in the central interior of British Columbia, Canada, to examine how forest disturbance altered the flow regimes and to discuss the possible ecological implications of these alterations. Equivalent clear‐cut area, an indicator combining all types of forest disturbances and accounting for hydrological recovery, was adopted to represent the cumulative forest disturbance levels over time at a watershed scale. Flow duration curves and time series cross‐correlation analysis were used to detect the statistical significance of relationships between flow regimes (magnitude, duration, timing, frequency and variability of high flows and low flows) and forest disturbance (clear‐cut area). The results showed that the magnitude of high flows was significantly increased and the timing of high flows was significantly advanced by forest disturbance. After forest disturbance, the occurrence of high flows with greater return periods became more frequent with increased variations. In addition, forest disturbance significantly increased the magnitude of low flows but with reduced variability. On average, high flows and low flows in the disturbed period were 31·4% and 16·0% greater than those in the reference period, respectively. Possible ecological implications of these hydrological alterations caused by forest disturbance were also discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Cocultures of GFP+‐granule cells with GFP−‐pyramidal cells and interneurons for the study of mossy fiber neurotransmission with paired recordings
Authors: Osorio Beatriz , León Uriel , Galván Emilio J. , Gutiérrez Rafael 
Published: February 2013

AbstractSynaptic transmission of the granule cells (GCs) via their axons, the mossy fibers (MFs), is traditionally studied on acutely prepared or cultured slices. Usually, extracellular, bulk or minimal stimulation is used to evoke transmitter release from MF terminals, while recording from their postsynaptic target cells, the pyramidal cells and interneurons of CA3. However, the ideal method to assess MF neurotransmission, the simultaneous recording of a presynaptic GC and one of its target cells, is extremely difficult to achieve using slices. Alternatively, cultures of GCs establishing autapses have been developed, but in these, GCs do not contact their natural targets. We developed cocultures of GCs, dissociated from transgenic GFP+ rats, with pyramidal cells and interneurons of CA3, dissociated from wild‐type rats, and confirmed the expression of cell‐specific markers by immunofluorescence. We conducted recordings of GFP+‐GCs synaptically connected with their GFP−‐target cells, and demonstrate that synaptic transmission and its plasticity have the signature of transmission of MF. Besides being strongly depressed by activation of mGluRs, high frequency activation of GC‐to‐pyramidal cells synapses undergo LTP, while GC‐to‐interneuron synapses undergo LTD. This coculture method allows a high reproducibility of recording connected pairs of identified cells, constituting a valuable tool to study MF transmission, as well as different combinations of identifiable pre‐ and postsynaptic cells. © 2013 Wiley Periodicals, Inc.
Rotating proton pumping ATPases: Subunit/subunit interactions and thermodynamics
Authors: Nakanishi‐Matsui Mayumi , Sekiya Mizuki , Futai Masamitsu 
Published: February 2013

AbstractIn this article, we discuss single molecule observation of rotational catalysis by E. coli ATP synthase (F‐ATPase) using small gold beads. Studies involving a low viscous drag probe showed the stochastic properties of the enzyme in alternating catalytically active and inhibited states. The importance of subunit interaction between the rotor and the stator, and thermodynamics of the catalysis are also discussed. “Single Molecule Enzymology” is a new trend for understanding enzyme mechanisms in biochemistry and physiology. © 2013 IUBMB Life, 65(3):247–254, 2013
Kinetic Study of Mercury(II) Transport through a Bulk Liquid Membrane Using Cyanex 301 as Carrier
Authors: Madaeni S. S. , Islami N. 
Published: February 2013

AbstractA kinetic study of Hg(II) ions transport through a bulk liquid membrane (BLM) was investigated. The commercially available liquid bis(2,4,4‐trimethyl(pentyl) dithiophosphinic acid) (Cyanex 301) was employed as mobile carrier. The influences of the carrier concentration in the liquid membrane, HNO3 concentration in the feed phase, type of organic solvent, composition of the receiving phase, and stirring speed on mass transfer were studied. Various solvents including CH2Cl2, CHCl3, C2H4Cl2 and CCl4 were used as organic membrane. Among the solvents, CHCl3 provided the superior results. The kinetic parameters (k1, k2, Rmmax, tmax, Jdmax, and Jamax) were calculated for the interface reaction assuming two consecutive, irreversible first‐order reactions. The analysis of Hg(II) accumulation in liquid membrane and the rate‐controlling step under different experimental conditions were elucidated. The experiments demonstrated that Cyanex 301 is an appropriate carrier for Hg(II) transport through liquid membrane.
Investigation of Some Functionalization Reactions of 4‐Benzoyl‐5‐phenyl‐1‐(4‐methoxyphenyl)‐1H‐pyrazole‐3‐carbonyl Chloride and Their Antimicrobial Activity
Authors: Korkusuz Elif , Yıldırım İsmail , Albayrak Sevil 
Published: February 2013

AbstractThe 1H‐pyrazole‐3‐carboxylic acid 1 was converted via reactions of its acid chloride 3 with various asymmetrical disubstituted urea and alcohol derivatives into the corresponding novel 4‐benzoyl‐N‐(N′,N′‐dialkylcarbamyl)‐1‐(4‐methoxyphenyl)‐5‐phenyl‐1H‐pyrazole‐3‐carboxamide 4a,b and alkyl 4‐benzoyl‐1‐(4‐methoxyphenyl)‐5‐phenyl‐1H‐pyrazole‐3‐carboxylate 7a‐c, respectively, in good yields (57%‐78%). Friedel‐Crafts reactions of 3 with aromatic compouns for 15 min.‐2 h led to the formation of the 4‐3‐diaroyl‐1‐(4‐hydroxyphenyl)‐5‐phenyl‐1H‐pyrazoles 9a‐c, 4‐benzoyl‐1‐(4‐methoxyphenyl)‐3‐aroyl‐5‐phenyl‐1H‐pyrazoles 10a,b and than from the acylation reactions of 9a‐c were obtained the 3,4‐diaroyl‐1‐(4‐acyloxyphenyl)‐5‐phenyl‐1H‐pyrazoles 13a‐d. The structures of all new synthesized compounds were established by NMR experiments such as 1H, and 13C, as well as 2D COSY and IR spectroscopic data, and elemental analyses. All the compounds were evaluated for their antimicrobial activities (agar diffusion method) against eight bacteria and two yeasts.
Abstracts of the 21st International Isotope Society (UK group) symposium: synthesis and applications of labelled compounds 2012
Authors: Årstad Erik , Badar Adam , Baxter Andrew , Bower John F. , Cable Karl M. , Carroll Michael A. , Chan Melanie Y. T. , Charlton Michael , Christlieb Martin , Cornelissen Bart , Cox Liam R. , Davis Ben , Dilworth Jonathan R. , El‐Emir Ethaar , Ellames George J. , Galante Eva , Geach Neil , Gee Antony D. , Gouverneur Véronique , Gregson Thomas J. , Hendry David , Hueting Rebekka , Hussien Kamila , Ilyas Tenzeela , Jenkins Daniel D. , Kersemans Veerle , Knagg Eric , Koepp Matthias , Kohler Andrew D. , Krauser Joel A. , Launay Guillaume G. , Lockley William J. S. , Lythgoe Mark F. , Manthorpe Daniel P. , McEwen Andrew , Muschel Ruth J. , Oldfield Mark F. , Passchier Jan , Pedley R. Barbara , Rajkumar Vineeth , Reed Christopher D. , Robson Mathew , Roe Stephen J. , Ryan Jim J. , Sander Kerstin , Shipley Nick , Smart Sean C. , Smith Neil , Spurr Daniel W. , Taylor Keith R. , Tredwell Matthew , Whitehead David M. , Woolley Geoffrey , Yan Ran 
Published: February 2013

Meeting SummaryThe 21st annual symposium of the International Isotope Society's United Kingdom Group took place at the Møller Centre, Churchill College, Cambridge, UK, on Friday 12th October 2012. The meeting was attended by around 60 delegates from academia and industry, the life sciences, chemical, radiochemical and scientific instrument suppliers.Delegates were welcomed by Dr Ken Lawrie (GlaxoSmithKline, UK, chair of the IIS UK group). The subsequent scientific programme consisted of oral and poster presentations on isotopic chemistry and applications of labelled compounds or of chemistry with potential implications for isotopic synthesis. Both short‐lived and long‐lived isotopes were represented, as were stable isotopes. The symposium programme was divided into a morning session chaired by Professor Chris Willis (University of Bristol, UK) and afternoon sessions chaired by Mr Mike Chappelle (Quotient Biosciences, UK) and by Dr Sofia Pascu (University of Bath, UK). The UK meeting concluded with remarks from Dr Ken Lawrie (GlaxoSmithKline, Stevenage, UK).
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Diversity in size and signal intensity in multilocular cystic ovarian masses: New parameters for distinguishing metastatic from primary mucinous ovarian neoplasms
Authors: Tanaka Yumiko Oishi , Okada Satoshi , Satoh Toyomi , Matsumoto Koji , Oki Akinori , Saida Tsukasa , Yoshikawa Hiroyuki , Minami Manabu 
Published: February 2013

PurposeTo differentiate primary mucinous ovarian neoplasms from metastatic ones with MR using diversity in size and signal intensity of multilocular cystic masses.Materials and MethodsTwenty‐eight cases of primary malignant or borderline mucinous malignant neoplasms and 14 metastatic ovarian tumors were retrospectively reviewed. We analyzed whether the tumor was unilateral or bilateral, the diversity in the size and signal intensity of each loculus in multilocular tumors, namely the size ratio of the smallest/largest loculus (size diversity ratio), and the standard deviation of the signal intensity at the level with the most varying signal on T2‐weighted images within tumors (signal diversity ratio). We performed statistical analysis using the Mann‐Whitney U‐test.ResultsBilateral tumors were more commonly observed among metastatic tumors than primary mucinous tumors (2/28 in primary versus 11/14 in metastatic, P < 0.01). The size diversity ratio was higher in primary mucinous tumors than in metastatic tumors (mean, 50.2 versus 23.2; P < 0.01). The signal diversity ratio was also higher in primary mucinous tumors than in metastatic tumors (334.3 versus 231.2; P < 0.01).ConclusionBilateral tumors were more common among metastatic tumors, which tended to be composed of cysts of uniform sizes and signal intensities compared with those of primary mucinous tumors. J. Magn. Reson. Imaging 2013;38:794–801. © 2013 Wiley Periodicals, Inc.
Stimulated echo diffusion tensor imaging and SPAIR T2‐weighted imaging in chronic exertional compartment syndrome of the lower leg muscles
Authors: Sigmund Eric E. , Sui Dabang , Ukpebor Obehi , Baete Steven , Fieremans Els , Babb James S. , Mechlin Michael , Liu Kecheng , Kwon Jane , Mcgorty KellyAnne , Hodnett Philip A. , Bencardino Jenny 
Published: February 2013

PurposeTo evaluate the performance of diffusion tensor imaging (DTI) in the evaluation of chronic exertional compartment syndrome (CECS) as compared to T2‐weighted (T2w) imaging.Materials and MethodsUsing an Institutional Review Board (IRB)‐approved, Health Insurance Portability and Accountability Act (HIPAA)‐compliant protocol, spectral adiabatic inversion recovery (SPAIR) T2w imaging and stimulated echo DTI were applied to eight healthy volunteers and 14 suspected CECS patients before and after exertion. Longitudinal and transverse diffusion eigenvalues, mean diffusivity (MD), and fractional anisotropy (FA) were measured in seven calf muscle compartments, which in patients were classified by their response on T2w: normal (<20% change), and CECS (>20% change). Mixed model analysis of variance compared subject groups and compartments in terms of response factors (post/pre‐exercise ratios) of DTI parameters.ResultsAll diffusivities significantly increased (P < 0.0001) and FA decreased (P = 0.0014) with exercise. Longitudinal diffusion responses were significantly smaller than transversal diffusion responses (P < 0.0001). Nineteen of 98 patient compartments were classified as CECS on T2w. MD increased by 3.8 ± 3.4% (volunteer), 7.4 ± 4.2% (normal), and 9.1 ± 7.0% (CECS) with exercise.ConclusionDTI shows promise as an ancillary imaging method in the diagnosis and understanding of the pathophysiology in CECS. Future studies may explore its utility in predicting response to treatment. J. Magn. Reson. Imaging 2013;38:1073–1082. © 2013 Wiley Periodicals, Inc.
Random laser from engineered nanostructures obtained by surface tension driven lithography
Authors: Ghofraniha Neda , Viola Ilenia , Maria Francesca Di , Barbarella Giovanna , Gigli Giuseppe , Conti Claudio 
Published: February 2013

AbstractThe random laser emission from the functionalized thienyl‐S,S‐dioxide quinquethiophene (T5OCx) in confined patterns with different shapes is demonstrated. Functional patterning of the light emitter organic material in well defined features is obtained by spontaneous molecular self‐assembly guided by surface tension driven (STD) lithography. Such controlled supramolecular nano‐aggregates act as scattering centers allowing the fabrication of one‐component organic lasers with no external resonator and with desired shape and efficiency. Atomic force microscopy shows that different geometric pattern with different supramolecular organization obtained by the lithographic process tailors the coherent emission properties by controlling the distribution and the size of the random scatterers.
Microarray analysis of port wine stains before and after pulsed dye laser treatment
Authors: Laquer Vivian T. , Hevezi Peter A. , Albrecht Huguette , Chen Tina S. , Zlotnik Albert , Kelly Kristen M. 
Published: February 2013

AbstractBackground and ObjectivesNeither the pathogenesis of port wine stain (PWS) birthmarks nor tissue effects of pulsed dye laser (PDL) treatment of these lesions is fully understood. There are few published reports utilizing gene expression analysis in human PWS skin. We aim to compare gene expression in PWS before and after PDL, using DNA microarrays that represent most, if not all, human genes to obtain comprehensive molecular profiles of PWS lesions and PDL‐associated tissue effects.Materials and MethodsFive human subjects had PDL treatment of their PWS. One week later, three biopsies were taken from each subject: normal skin (N); untreated PWS (PWS); PWS post‐PDL (PWS + PDL). Samples included two lower extremity lesions, two facial lesions, and one facial nodule. High‐quality total RNA isolated from skin biopsies was processed and applied to Affymetrix Human gene 1.0ST microarrays for gene expression analysis. We performed a 16 pair‐wise comparison identifying either up‐ or down‐regulated genes between N versus PWS and PWS versus PWS + PDL for four of the donor samples. The PWS nodule (nPWS) was analyzed separately.ResultsThere was significant variation in gene expression profiles between individuals. By doing pair‐wise comparisons between samples taken from the same donor, we were able to identify genes that may participate in the formation of PWS lesions and PDL tissue effects. Genes associated with immune, epidermal, and lipid metabolism were up‐regulated in PWS skin. The nPWS exhibited more profound differences in gene expression than the rest of the samples, with significant differential expression of genes associated with angiogenesis, tumorigenesis, and inflammation.ConclusionIn summary, gene expression profiles from N, PWS, and PWS + PDL demonstrated significant variation within samples from the same donor and between donors. By doing pair‐wise comparisons between samples taken from the same donor and comparing these results between donors, we were able to identify genes that may participate in formation of PWS and PDL effects. Our preliminary results indicate changes in gene expression of angiogenesis‐related genes, suggesting that dysregulation of angiogenic signals and/or components may contribute to PWS pathology. Lasers Surg. Med. 45: 67–75, 2013. © 2012 Wiley Periodicals, Inc.
Navigating Residue Sensitivity in the Used Goods Marketplace
Authors: Kapitan Sommer , Bhargave Rajesh 
Published: February 2013

ABSTRACTHow does a previous owner's contact with used goods affect consumer judgments of these objects? This research identifies a trait measure of sensitivity to the residue of another's essence or taint found in a used possession. Those highly sensitive to residue respond to the transfer of contaminants from a previous owner of an object. Six samples in Study 1 show that residue sensitivity is a reliable and valid measure that is related to constructs of possession attachment and disease transfer. Still, residue sensitivity explains consumer behavior in the secondhand marketplace in ways that these existing constructs do not. Studies 2 and 3 illustrate how consumers highly sensitive to residue shift their judgments of secondhand goods according to information about the valence of a source of prior ownership.
Atypical parkinsonism due to a D202N Gerstmann‐Sträussler‐Scheinker prion protein mutation: First in vivo diagnosed case
Authors: Plate Annika , Benninghoff Jens , Jansen Gerald H. , Wlasich Elisabeth , Eigenbrod Sabina , Drzezga Alexander , Jansen Nathalie L. , Kretzschmar Hans A. , Bötzel Kai , Rujescu Dan , Danek Adrian 
Published: February 2013

Background: Parkinsonism with dopa‐sensitivity and a correlating DaTSCAN turned out to be due to a D202N mutation which is associated with Gerstmann‐Sträussler‐Scheinker (GSS) disease.Methods/Results: We report a 51‐year old female who presented with left‐dominant parkinsonism and a positive DaTSCAN. She was diagnosed with idiopathic Parkinson's syndrome. Dopaminergic medication reduced her symptoms. In addition, punding‐like behavior, deficits in organizing daily life and abnormal sleep behavior were reported. Neuropsychological testing, EEG, polysomnography as well as PET imaging with fluorodexyglucose (FDG), [F‐18]‐desmethoxyfallypride (DMFP), and [C‐11]‐6‐OH‐BTA‐1 (PIB) were not diagnostic. Cerebral spinal fluid analysis revealed no 14‐3‐3 protein, but elevated neuron‐specific enolase (NSE) and S100‐beta and a very low phospho‐tau/total‐tau ratio. Analysis of the prion gene disclosed the rare D202N mutation.Conclusions: The D202N prion mutation has been associated with GSS pathology and up to now was only reported post mortem. Our patient is the very first case diagnosed in vivo. © 2013 Movement Disorder Society
Validation of a screening battery to predict driving fitness in people with Parkinson's disease
Authors: Devos Hannes , Vandenberghe Wim , Nieuwboer Alice , Tant Mark , De Weerdt Willy , Dawson Jeffrey D. , Uc Ergun Y. 
Published: February 2013

ABSTRACTBackgroundWe previously developed a short clinical battery, consisting of contrast sensitivity, Clinical Dementia Rating, the Unified Parkinson's Disease Rating Scale‐motor section (UPDRSIII), and disease duration, which correctly classified 90% of drivers with Parkinson's Disease (PD). The aim of this study was to validate that screening battery in a different sample ofPDdrivers.MethodsSixty drivers with PD were enrolled to validate our original screening battery to predict driving fitness decisions (pass–fail) by a state agency where drivers underwent detailed visual, cognitive, and on‐road testing.ResultsTwenty‐four participants (40%) failed the driving evaluation. The screening battery correctly classified 46 (77%) participants (sensitivity and negative predictive value = 96%; specificity and positive predictive value = 64%). Adding other clinical predictors (e.g., age of onset, Hoehn‐Yahr stage instead of UPDRS III) failed to improve the specificity of the model when the sensitivity was kept constant at 96%. However, a driving simulator evaluation improved the specificity of the model to 94%.ConclusionsThe original clinical battery proved to be a valid screening tool that accurately identifies fit drivers with PD and select those who need more detailed testing at specialized centers. © 2013MovementDisorder Society