bluuebunny/crossref_metadata_2025_split huggingface dataset:
Targeting RET–interleukin-6 crosstalk to impair metastatic dissemination in breast cancer
Authors: Morandi Andrea , Isacke Clare M 
Published: January 2014

AbstractRET (rearranged during transfection) is a receptor tyrosine kinase overexpressed in a subset of oestrogen receptor (ER)-positive breast cancers whose expression is regulated by ER signalling. The article from the Hynes group has reported for the first time that RET expression can also be regulated by the inflammatory cytokine IL-6. Importantly, RET and IL-6 interact at a functional level to control migration and the metastatic potential of ER-positive breast cancer cells, in a process that is mediated by FAK activation. Further, targeting RET with receptor tyrosine kinase inhibitors was reported to be more effective than endocrine therapies in impairing metastatic dissemination in vivo, thereby indicating a level of RET regulation that is independent of ER.
Long-Term Results of Laparoscopic Gastrectomy for Gastric Cancer: A Large-Scale Case-Control and Case-Matched Korean Multicenter Study
Authors: Kim Hyung-Ho , Han Sang-Uk , Kim Min-Chan , Hyung Woo Jin , Kim Wook , Lee Hyuk-Joon , Ryu Seung Wan , Cho Gyu Seok , Song Kyo Young , Ryu Seong Yeob 
Published: January 2014

Purpose The oncologic outcomes of laparoscopy-assisted gastrectomy for the treatment of gastric cancer have not been evaluated. The aim of this study is to validate the efficacy and safety of laparoscopic gastrectomy for gastric cancer in terms of long-term survival, morbidity, and mortality retrospectively. Patients and Methods The study group comprised 2,976 patients who were treated with curative intent either by laparoscopic gastrectomy (1,477 patients) or open gastrectomy (1,499 patients) between April 1998 and December 2005. The long-term 5-year actual survival analysis in case-control and case-matched population was conducted using the Kaplan-Meier method. The morbidity and mortality and learning curves were evaluated. Results In the case-control study, the overall survival, disease-specific survival, and recurrence-free survival (median follow-up period, 70.8 months) were not statistically different at each cancer stage with the exception of an increased overall survival rate for patients with stage IA cancer treated via laparoscopy (laparoscopic group; 95.3%, open group: 90.3%; P < .001). After matching using a propensity scoring system, the overall survival, disease-specific survival, and recurrence-free survival rates were not statistically different at each stage. The morbidity of the case-matched group was 15.1% in the open group and 12.5% in the laparoscopic group, which also had no statistical significance (P = .184). The mortality rate was also not statistically significant (0.3% in the open group and 0.5% in the laparoscopic group; P = 1.000). The mean learning curve was 42. Conclusion The long-term oncologic outcomes of laparoscopic gastrectomy for patients with gastric cancer were comparable to those of open gastrectomy in a large-scale, multicenter, retrospective clinical study.
Hyaluronan Synthase 3 Variant and Anthracycline-Related Cardiomyopathy: A Report From the Children's Oncology Group
Authors: Wang Xuexia , Liu Wei , Sun Can-Lan , Armenian Saro H. , Hakonarson Hakon , Hageman Lindsey , Ding Yan , Landier Wendy , Blanco Javier G. , Chen Lu , Quiñones Adolfo , Ferguson Daniel , Winick Naomi , Ginsberg Jill P. , Keller Frank , Neglia Joseph P. , Desai Sunil , Sklar Charles A. , Castellino Sharon M. , Cherrick Irene , Dreyer ZoAnn E. , Hudson Melissa M. , Robison Leslie L. , Yasui Yutaka , Relling Mary V. , Bhatia Smita 
Published: January 2014

PurposeThe strong dose-dependent association between anthracyclines and cardiomyopathy is further exacerbated by the co-occurrence of cardiovascular risk factors (diabetes and hypertension). The high morbidity associated with cardiomyopathy necessitates an understanding of the underlying pathogenesis so that targeted interventions can be developed.Patients and MethodsBy using a two-stage design, we investigated host susceptibility to anthracycline-related cardiomyopathy by using the ITMAT/Broad CARe cardiovascular single nucleotide polymorphism (SNP) array to profile common SNPs in 2,100 genes considered relevant to de novo cardiovascular disease.ResultsBy using a matched case-control design (93 cases, 194 controls), we identified a common SNP, rs2232228, in the hyaluronan synthase 3 (HAS3) gene that exerts a modifying effect on anthracycline dose-dependent cardiomyopathy risk (P = 5.3 × 10−7). Among individuals with rs2232228 GG genotype, cardiomyopathy was infrequent and not dose related. However, in individuals exposed to high-dose (> 250 mg/m2) anthracyclines, the rs2232228 AA genotype conferred an 8.9-fold (95% CI, 2.1- to 37.5-fold; P = .003) increased cardiomyopathy risk compared with the GG genotype. This gene-environment interaction was successfully replicated in an independent set of 76 patients with anthracycline-related cardiomyopathy. Relative HAS3 mRNA levels measured in healthy hearts tended to be lower among individuals with AA compared with GA genotypes (P = .09).ConclusionHyaluronan (HA) produced by HAS3 is a ubiquitous component of the extracellular matrix and plays an active role in tissue remodeling. In addition, HA is known to reduce reactive oxygen species (ROS) –induced cardiac injury. The high cardiomyopathy risk associated with AA genotype could be due to inadequate remodeling and/or inadequate protection of the heart from ROS-mediated injury on high anthracycline exposure.
Burnout and Career Satisfaction Among US Oncologists
Authors: Shanafelt Tait D. , Gradishar William J. , Kosty Michael , Satele Daniel , Chew Helen , Horn Leora , Clark Ben , Hanley Amy E. , Chu Quyen , Pippen John , Sloan Jeff , Raymond Marilyn 
Published: January 2014

Purpose To evaluate the personal and professional characteristics associated with career satisfaction and burnout among US oncologists. Methods Between October 2012 and March 2013, the American Society of Clinical Oncology conducted a survey of US oncologists evaluating burnout and career satisfaction. The survey sample included equal numbers of men and women and represented all career stages. Results Of 2,998 oncologists contacted, 1,490 (49.7%) returned surveys (median age of respondents, 52 years; 49.6% women). Among the 1,117 oncologists (37.3% of overall sample) who completed full-length surveys, 377 (33.8%) were in academic practice (AP) and 482 (43.2%) in private practice (PP), with the remainder in other settings. Oncologists worked an average of 57.6 hours per week (AP, 58.6 hours per week; PP, 62.9 hours per week) and saw a mean of 52 outpatients per week. Overall, 484 oncologists (44.7%) were burned out on the emotional exhaustion and/or depersonalization domain of Maslach Burnout Inventory (AP, 45.9%; PP, 50.5%; P = .18). Hours per week devoted to direct patient care was the dominant professional predictor of burnout for both PP and AP oncologists on univariable and multivariable analyses. Although a majority of oncologists were satisfied with their career (82.5%) and specialty (80.4%) choices, both measures of career satisfaction were lower for those in PP relative to AP (all P < .006). Conclusion Overall career satisfaction is high among US oncologists, albeit lower for those in PP relative to AP. Burnout rates among oncologists seem similar to those described in recent studies of US physicians in general. Those oncologists who devote the greatest amount of their professional time to patient care seem to be at greatest risk for burnout.
Yoga's Impact on Inflammation, Mood, and Fatigue in Breast Cancer Survivors: A Randomized Controlled Trial
Authors: Kiecolt-Glaser Janice K. , Bennett Jeanette M. , Andridge Rebecca , Peng Juan , Shapiro Charles L. , Malarkey William B. , Emery Charles F. , Layman Rachel , Mrozek Ewa E. , Glaser Ronald 
Published: January 2014

Purpose To evaluate yoga's impact on inflammation, mood, and fatigue. Patients and Methods A randomized controlled 3-month trial was conducted with two post-treatment assessments of 200 breast cancer survivors assigned to either 12 weeks of 90-minute twice per week hatha yoga classes or a wait-list control. The main outcome measures were lipopolysaccharide-stimulated production of proinflammatory cytokines interleukin-6 (IL-6), tumor necrosis factor alpha (TNF-α), and interleukin-1β (IL-1β), and scores on the Multidimensional Fatigue Symptom Inventory-Short Form (MFSI-SF), the vitality scale from the Medical Outcomes Study 36-item Short Form (SF-36), and the Center for Epidemiological Studies-Depression (CES-D) scale. Results Immediately post-treatment, fatigue was not lower (P > .05) but vitality was higher (P = .01) in the yoga group compared with the control group. At 3 months post-treatment, fatigue was lower in the yoga group (P = .002), vitality was higher (P = .01), and IL-6 (P = .027), TNF-α (P = .027), and IL-1β (P = .037) were lower for yoga participants compared with the control group. Groups did not differ on depression at either time (P > .2). Planned secondary analyses showed that the frequency of yoga practice had stronger associations with fatigue at both post-treatment visits (P = .019; P < .001), as well as vitality (P = .016; P = .0045), but not depression (P > .05) than simple group assignment; more frequent practice produced larger changes. At 3 months post-treatment, increasing yoga practice also led to a decrease in IL-6 (P = .01) and IL-1β (P = .03) production but not in TNF-α production (P > .05). Conclusion Chronic inflammation may fuel declines in physical function leading to frailty and disability. If yoga dampens or limits both fatigue and inflammation, then regular practice could have substantial health benefits.
Skeletal Muscle Characteristics and Motor Performance After 2-Year Growth Hormone Treatment in Adults With Prader-Willi Syndrome
Authors: Lafortuna Claudio L. , Minocci Alessandro , Capodaglio Paolo , Gondoni Luca A. , Sartorio Alessandro , Vismara Luca , Rizzo Giovanna , Grugni Graziano 
Published: January 2014

Context:In adults with Prader-Willi syndrome (PWS), abnormal body composition with decreased lean body mass and skeletal muscle (SM) volume has been related to altered GH secretion and may possibly contribute to greatly reduced motor capacity.Objective:The scope of the study was to test the hypothesis that GH treatment has favorable effects on SM characteristics and motor performance in adults with PWS.Design, Setting, and Participants:Fifteen obese PWS subjects (nine males and six females; age range, 19–35 y; body mass index, 37.7–59.9 kg/m2) were investigated before and after 12 (GH12) and 24 (GH24) months of GH treatment.Main Outcome Measures:SM cross-sectional area and SM attenuation were determined with computed tomography at the lumbar and midthigh levels. Maximal isometric handgrip strength and isokinetic knee extension peak torque were measured. Motor performance was evaluated with different indoor walking tests, whereas exercise endurance was assessed with a treadmill incremental test to exhaustion.Results:A condition of severe GH deficiency was found in six patients (40%). GH treatment significantly increased lean body mass (GH12, P &lt; .05; GH24, P &lt; .05), reduced percentage of body fat (GH12, P &lt; .05; GH24, P &lt; .05), and augmented SM cross-sectional area and SM attenuation of both lumbar (GH12, P &lt; .01; GH24, P &lt; .001) and thigh muscles (GH24, P &lt; .05). Handgrip strength increased by 7% at GH12 (P &lt; .05) and by 13% at GH24 (P &lt; .001). Peak torque of knee extension extrapolated at zero angular velocity was significantly higher at GH24 (P &lt; .01), and exercise endurance rose by 13% (P &lt; .05) and 17% (P &lt; .05) before exhaustion at GH12 and GH24, respectively, whereas no change was detected with walking tests. No significant difference in the response to GH treatment was detected between patients with and without GH deficiency.Conclusion:Long-term GH treatment in adult PWS patients improves body composition and muscle size and quality and increases muscle strength and exercise tolerance independently from the GH secretory status.
Energy Transfer from Sn2+ to RE3+ Cations in ZnO–P2O5 Glass
Authors: Masai Hirokazu , Hino Yusuke , Yanagida Takayuki , Fujimoto Yutaka , Yoko Toshinobu 
Published: January 2014

Abstract
The photoluminescence (PL) properties of rare earth (RE)-doped SnO–ZnO–P2O5 (RE-SZP) glass were examined in the visible region. RE-SZP glass, except for those doped with Ce3+, exhibited similar optical band edges because of the s–p transition in Sn2+. The RE3+ PL excitation bands in RE-SZP glass were red-shifted compared to the bands in Sn-free glass because of the energy transfer from the Sn2+ center. In addition, the emission intensity in a few RE-SZP glass systems was remarkably enhanced by Sn2+ addition. Emission decays of Sn2+ in the glass were typically independent of the RE3+, and suggest the exchange interaction between Sn2+ and RE3+. This indicated that the RE3+ cation is generally located close to the Sn2+ center in order to allow energy transfer.
Do Parents’ Social Skills Influence Their Children’s Sociability?
Authors: Okumura Tsunao , Usui Emiko 
Published: January 2014

Abstract
This article uses the U.S. National Longitudinal Survey of Youth 1979 (NLSY79) to examine the effect of parents’ social skills on their children’s sociability. Similar to many other national surveys, this survey lacks detailed information on parents. To remedy this deficiency, we construct a measure of parents’ sociability skills based on their occupational characteristics extracted from the Dictionary of Occupational Titles (DOT). Even after controlling for a variety of background characteristics, including cognitive skills, we find that the sociability relationships between fathers and sons and between mothers and daughters remain statistically significant. We find that the dollar value to the sons of a given increase in their fathers’ sociability is one-sixth of the value to the sons of the same standard-deviation increase in their fathers’ education.
Pd Supported on SnO2-Al2O3 Composite Supports for CO Oxidation – Designing Thermally Stable and Active Supports for Pd
Authors: Xu Xianglan , Wang Xiang , Li Yucheng , Tian Jinshu , Liu Wenming , Gao Zhixian 
Published: January 2014

Abstract
A series of SnO2-Al2O3 composite metal oxide
supports with different Sn/Al atomic ratios were synthesized with
co-precipitation method and used as supports for Pd to prepare
catalysts for CO oxidation. The samples were characterized by
N2 adsorption-desorption, CO adsorption-desorption, X-ray
Powder Diffraction (XRD), H2 temperature programmed
reduction (H2 TPR), and X-ray photoelectron spectroscopy
(XPS) techniques. It was found that Al3+ can be introduced
into the crystalline lattice of tetragonal rutile SnO2 to
effectively form solid solution structure. As a consequence,
SnO2-Al2O3 binary supports with significantly
improved thermal stability, enlarged surface areas, enhanced texture
structure and containing more active surface oxygen species can be
obtained. SnAl73, a support with a Sn/Al atomic ratio of 7/3, was
found to be the best support in this study due to its certain large
surface area and the presence of suitable amount of reducible oxygen
species. With this support, the two major reasons accounting for the
activity, that is, Pd dispersion and strong metal support interaction
(SMSI) between Pd and the support, is believed to be tuned
optimally. Water vapor has reversible effect on the CO oxidation
activity of Pd/SnAl73 catalyst, but which is mitigated evidently by
the presence of SnO2. In addition, no any permanent
deactivation occurs to Pd/SnAl73 catalyst during a 60 hours' test
in the presence or absence of water vapor, indicating this optimized
SnO2-Al2O3 support has a strong potential to be
applied in some practical processes for exhaust clean. In summary,
SnO2-Al2O3 composite metal oxides with suitable
Sn/Al atomic ratios are better supports than individual
Al2O3 and SnO2, on which less amount of Pd
could be used to achieve supported Pd catalysts with rival
performance.
Representation of “Broad” Falloff Curves for Dissociation and Recombination Reactions
Authors: Troe Jürgen , Ushakov Vladimir G. 
Published: January 2014

Abstract
Expressions for representing the pressure dependence of unimolecular
dissociation and the reverse recombination reactions are
compared. Situations are considered where the broadening of the
corresponding falloff curves is particularly pronounced, i.e. where
broadening factors at the center of the falloff curves,
F
cent, are very small and falloff curves correspondingly
become very “broad”. Such situations arise when unimolecular
reactions of molecules with large numbers of low-frequency modes and
high-temperature situations are considered. Recombination reactions of
polyatomic species in atmospheric chemistry and dissociation reactions
of large molecules in combustion are the fields of application of the
present results. While previously proposed expressions for asymmetric
broadening factors showed artifacts when F
cent decreased
to values below about 0.4, alternative functions are described which
avoid these problems for situations where F
cent decreases
to values far below 0.1.
Probe of the Replenishment Strategy and Grouping Rule in the Semiconductor Industry
Authors: Chang Yung-Chia , Chang Kuei-Hu , Lei Yi-Chieh 
Published: January 2014

Abstract
The theory of constraint suggests the application of a demand-pull replenishment strategy combined with buffer management (DPBM) in order to effectively manage inventory. A demand-pull strategy caters to the customers’ demand to drive inventory replenishment, while buffer management is designed to adjust target inventory levels (buffer size). However, there is very limited literature looking into the parameters of buffer management in depth, such as the timing and the amount of buffer adjusted. Therefore, the objective of this study was to explore the product demand characteristics that affect the parameters of choice in buffer management when applying the DPBM strategy. This study first used a DPBM strategy (implemented via simulation, based on historical demand data) under different buffer management parameters to simulate the inventory replenishment for multiple products. The products were then grouped according to the simulated results by statistical analysis. A decision tree was applied to find the critical demand pattern factors that determined the product groups. An appropriate DPBM strategy is suggested for each product group. This study uses real demand data for 21 products, provided by a wafer foundry company located in Taiwan, to demonstrate the feasibility and effectiveness of the proposed method. The results show that it is possible to determine whether a product is suitable for DPBM strategy application after analyzing only its historical demand data.
Improved Rolling Dynamic Deflectometer for Continuous Pavement Deflection Measurements
Authors: Nam BooHyun , Stokoe Kenneth H. 
Published: January 2014

Abstract
Unlike discrete testing methods, the rolling dynamic deflectometer (RDD) performs continuous measurements. Thus, it is a powerful screening and evaluation tool for quickly characterizing large sections of highway and airfield pavements with little danger of missing critical pavement features. RDD testing applications have involved (1) pavement forensic investigations, (2) delineations of areas to be repaired, (3) selections of rehabilitation treatments, measurements of relative improvements due to the rehabilitation, and (4) monitoring of changes with time (trafficking and environmental loading). This paper discusses the efforts to improve the velocity of RDD testing up to 5 mph (8.0 km/h) while minimizing the accuracy and resolution of deflection data. The research consisted of the development of a velocity-improved rolling sensor and the field evaluation of its new sensor system. The velocity-improved rolling sensor and the enhanced data processing were tested in both flexible and rigid pavements at varied velocities. The enhanced RDD system potentially enabled testing velocities of up to 5 mph (8.0 km/h) in thin flexible pavements (i.e., farm-to-market roads) and up to 3 mph (4.8 km/h) in rigid pavements.
An Edge-Heating Device for Optical Measurement of Thermochromic Glazing Materials and Recommended Test Procedure
Authors: Jonsson Jacob C. , Goudey Howdy , Curcija Charlie 
Published: January 2014

Abstract
Thermochromic materials have optical properties that vary with temperature. To simulate energy performance of such materials, it is important to have spectral data in the solar range, 300–2500 nm, for each temperature that the material will have in the simulation. This paper describes a temperature control strategy that allows for measurement of reflectance and transmittance at a fixed temperature using a commercial spectrophotometer. A specimen frame is used to clamp heating strips to the surface at the edge of the sample that is being tested. Multiple thermocouples are used to monitor the temperature gradient over the sample as the center is cooler than the edge. Verification using an infrared (IR) camera and time-resolved transmittance measurements show that the center sample temperature is stable and how long it takes to achieve equilibrium. An interpolation method is described and verified to reduce the number of states that need to be measured. A recommended test procedure is described and used on two different materials.
Investigations on Wood–Plastic Composites Reinforced With Silica Particles Using Design of Experiment
Authors: Silva Alan Sousa , Martuscelli Carolina Coelho , Panzera Túlio Hallak , Ribeiro Borges Paulo Henrique , Christoforo André Luis 
Published: January 2014

Abstract
Incineration and landfilling of waste from the timber industry are practices condemned and unused. The reuse of wood waste as a dispersive phase in composite materials has been the focus of much research to develop new products, mainly for the automotive and construction industries. The wood–plastic composites (WPC) present characteristics, such as moderate strength, light weight, and high durability. Besides, they are inexpensive and sustainable, which make them attractive for innovative design. This work investigates the effect of eucalyptus sawdust, a chemical admixture and silica particles on the physical and mechanical properties of WPC upon a statistical methodology. The silica-particle addition was added by the matrix phase replacement to reduce the overall costs, because the latter is nearly 87 % more expensive. A microstructural analysis was conducted to better assess the variables studied. Results have shown that the composites made with 20 wt. % of sawdust addition, 10/50 US-Tyler sawdust particle size and maleic anhydride addition appeared to have acceptable properties for engineering applications.