bluuebunny/crossref_metadata_2025_split huggingface dataset:
INITIAL FUNCTIONAL ANALYSIS OUTCOMES AND MODIFICATIONS IN PURSUIT OF DIFFERENTIATION: A SUMMARY OF 176 INPATIENT CASES
Authors: Hagopian Louis P. , Rooker Griffin W. , Jessel Joshua , DeLeon Iser G. 
Published: April 2013

AbstractThe functional analysis (FA) described by Iwata, Dorsey, Slifer, Bauman, and Richman (1982/1994) delineated not only a set a specific procedures, but also a model that involves the use of analogue conditions wherein antecedent and consequent variables are systematically manipulated. This consecutive case‐series analysis describes FAs of 176 individuals with intellectual disabilities who had been admitted to an inpatient unit for severe problem behavior. Following an initial standardized FA, additional modifications were performed in pursuit of differentiation. Ultimately, a function was identified in 86.9% of the 176 cases and in 93.3% of the 161 cases for which the FA, if necessary, was modified up to 2 times. All modifications were documented and classified as involving changes to antecedents, consequences, or design (or some combination of these). Outcomes for each type of modification are reported. The results support the utility of ongoing hypothesis testing through individualized modifications to FA procedures, and provide information regarding how each type of modification affected results.
CONDUCTING FUNCTIONAL ANALYSES OF PROBLEM BEHAVIOR VIA TELEHEALTH
Authors: Wacker David P. , Lee John F. , Dalmau Yaniz C. Padilla , Kopelman Todd G. , Lindgren Scott D. , Kuhle Jennifer , Pelzel Kelly E. , Waldron Debra B. 
Published: April 2013

AbstractBehavior consultants conducted functional analyses (FAs) via telehealth with 20 young children with autism spectrum disorders between the ages of 29 and 80 months who displayed problem behavior and lived an average of 222 miles from the tertiary hospital that housed the behavior consultants. Participants' parents conducted all procedures during weekly telehealth consultations in regional clinics located an average of 15 miles from the participants' homes. Behavior consultants briefly trained parent assistants to provide on‐site support for families during consultations. FAs completed within a multielement design identified environmental variables that maintained problem behavior for 18 of the 20 cases, and interrater agreement averaged over 90%. Results suggested that behavior analysts can conduct FAs effectively and efficiently via telehealth.
A pH‐sensitive binary drug delivery system based on poly(caprolactone)–heparin conjugates
Authors: Ye Lin , Gao Zemin , Zhou Yu , Yin Xuan , Zhang Xinpeng , Zhang Aiying , Feng Zengguo 
Published: April 2013

AbstractPCL‐heparin conjugates were synthesized by coupling mono‐hydroxyl terminated PCL (Mn = 2000‐10000 g/mol) with heparin via EDC/NHS chemistry. The conjugates enabled to self‐assemble into the core‐shell nanoparticles in around 100 nm diameter to load binary anti‐cancer drugs. Lipophilic and neutral paclitaxel (PTX) was first encapsulated in the core, and then hydrophilic and positive charged doxorubicin (DOX) was incorporated into the negative charged shell of PTX loaded nanoparticles via the electrostatic interaction. The in vitro release profiles of the binary‐drug loaded nanoparticles revealed that both PTX and DOX were sustainably released from the particles but behaved differently. The release of DOX was pH dependent, ensuring more drug to be released in the tumor cells than in the normal ones. Hence these particles were featured by a sequential controlled drug delivery behavior with a significant cytotoxicity to cervical cancer (Hela cell) and breast cancer (MDA‐MB‐321) cells. The CLSM observations clearly indicated that both loaded PTX and DOX aggregated in the nucleus of tumor cells to exert their anti‐tumor pharmacodynamic effect on the cells. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 880–889, 2014.
Composition‐dependent protein secretion and integrin level of osteoblastic cell on calcium silicate cements
Authors: Shie Ming‐You , Chang Hsien‐Chang , Ding Shinn‐Jyh 
Published: April 2013

AbstractThe purpose of this study was to investigate the responses of the human osteosarcoma cell line MG63 to calcium silicate cements with different Si/Ca molar ratios and different surface roughness. In particular, the study evaluated integrin subunit levels, phosphor‐focal adhesion kinase (pFAK) levels and protein production at the cell attachment stage. The results indicated that the surface roughness (variations within a factor of 10) of the cements did not play a prominent role in cell attachment and proliferation, but the effect of composition was highlighted. IncreasedpFAKand total integrin levels and promoted cell attachment and cell cycle progression were observed upon an increase in cement Si content. Cement with a higher Si content was beneficial for collagen Type I (COL I) adsorption,COL Isecretion, andαlibβ3subintegrin expression, whereas cement with a higher Ca content increased fibronectin (FN) adsorption,FNsecretion, and enhancedαvβ1subintegrin levels. These results establish composition‐dependent differences in integrin binding as a mechanism regulating cellular responses to biomaterial surfaces. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 769–780, 2014.
Biocompatibility of TiO2 nanotubes with different topographies
Authors: Wang Yu , Wen Cuie , Hodgson Peter , Li Yuncang 
Published: April 2013

AbstractThe biological response of osteoblast cells to implant materials depends on the topography and physico‐chemistry of the implant surface and this determines the cell behavior such as shaping, adhesion and proliferation, and finally the cell fate. In this study, titanium (Ti) was anodized to create different topographies of titania nanotubes (TNTs) to investigate the cell behavior to them. TNTs with and without a highly ordered nanoporous layer on their top surface were fabricated using two‐step and one‐step anodizing processes, respectively. The TNTs without a highly ordered nanoporous layer on the top surface exhibited a rougher surface, higher surface energy and better hydrophilicity than the TNTs with such a layer. Osteoblast‐like cells (SaOS2) were used to assess the biocompatibility of the TNTs with different topographies in comparison to bare cp‐Ti. Results indicated that TNTs can enhance the proliferation and adhesion of osteoblast‐like cells. TNTs without a highly ordered nanoporous layer exhibited better biocompatibility than the TNTs covered by such a nanoporous layer. Cell morphology observation using confocal microscopy and SEM indicated that SaOS2 cells that were adhered to the TNTs without the highly ordered nanoporous layer showed the longest filopodia compared to TNTs with a highly ordered nanoporous layer and bare cp‐Ti. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 743–751, 2014.
Novel role of miR‐181a in cartilage metabolism
Authors: Sumiyoshi Kumi , Kubota Satoshi , Ohgawara Toshihiro , Kawata Kazumi , Abd El Kader Tarek , Nishida Takashi , Ikeda Nao , Shimo Tsuyoshi , Yamashiro Takashi , Takigawa Masaharu 
Published: April 2013

AbstractMicro RNA (miRNA) is a small non‐coding post‐transcriptional RNA regulator that is involved in a variety of biological events. In order to specify the role of miRNAs in cartilage metabolism, we comparatively analyzed the expression profile of known miRNAs in chicken sternum chondrocytes representing early and late differentiation stages. Interestingly, none of the miRNAs displaying strong expression levels showed remarkable changes along with differentiation, suggesting their roles in maintaining the homeostasis rather than cytodifferentiation of chondrocytes. Among these miRNAs, miR‐181a, which is known to play critical roles in a number of tissues, was selected and was further characterized. Human microarray analysis revealed remarkably stronger expression of miR‐181a in human HCS‐2/8 cells, which strongly maintained a chondrocytic phenotype, than in HeLa cells, indicating its significant role in chondrocytes. Indeed, subsequent investigation indicated that miR‐181a repressed the expression of two genes involved in cartilage development. One was CCN family member 1 (CCN1), which promotes chondrogenesis; and the other, the gene encoding the core protein of aggrecan, a major cartilaginous proteoglycan, aggrecan. Based on these findings, negative feedback system via miR‐181a to conserve the integrity of the cartilaginous phenotype may be proposed. J. Cell. Biochem. 114: 2094–2100, 2013. © 2013 Wiley Periodicals, Inc.
Frequency‐dependent cell death by optical tweezers manipulation
Authors: NG K.S. , ZHOU Z.L. , NGAN A.H.W. 
Published: April 2013

AbstractOptical tweezers were used to scan individual Chronic Myelogenous Leukemia cells to determine if the cell death depends on the scanning conditions. Although increasing the scanning frequency or amplitude means greater force applied to the cells, their effects on cell death are not a simple increasing trend, as observed in the optical microscopy. Indeed, cell death sharply increased at particular screening frequencies and amplitudes, whereas other frequencies or amplitudes were less detrimental. These results suggest that cell damage was more sensitive to certain scanning conditions, rather than simply high‐applied forces. J. Cell. Physiol. 228: 2037–2041, 2013. © 2013 Wiley Periodicals, Inc.
Induction of STEAP4 correlates with 1,25‐dihydroxyvitamin D3 stimulation of adipogenesis in mesenchymal progenitor cells derived from human adipose tissue
Authors: Narvaez C. J. , Simmons K. M. , Brunton J. , Salinero A. , Chittur S. V. , Welsh J. E. 
Published: April 2013

ABSTRACTThe vitamin D receptor (VDR) is expressed in human adipocytes and is transiently induced during early adipogenesis in mesenchymal progenitor cell models. VDR null mice exhibit enhanced energy expenditure and reduced adiposity even when fed high fat diets. Adipocyte‐specific transgenic‐expression of human VDR in mice enhances adipose tissue mass, indicating that VDR activation in adipocytes enhances lipid storage in vivo. In these studies, we conducted genomic profiling and differentiation assays in primary cultures of human adipose‐derived mesenchymal progenitor cells to define the role of the VDR and its ligand 1,25‐dihydroxyvitamin D3 (1,25D) in adipogenesis. In the presence of adipogenic media, 1,25D promoted lipid accumulation and enhanced the expression of FABP4, FASN, and PPARγ. Mesenchymal cells derived from 6‐month old VDR null mice exhibited impaired adipogenesis ex vivo but differentiation was restored by stable expression of human VDR. STEAP4, a gene that encodes a metalloreductase linked to obesity, insulin sensitivity, metabolic homeostasis and inflammation, was highly induced in human adipose cells differentiated in the presence of 1,25D but was minimally affected by 1,25D in undifferentiated precursors. These studies provide a molecular basis for recent epidemiological associations between vitamin D status, body weight and insulin resistance which may have relevance for prevention or treatment of metabolic syndrome and obesity. J. Cell. Physiol. 228: 2024–2036, 2013. © 2013 Wiley Periodicals, Inc.
Reversal of cardiac dysfunction and subcellular alterations by metoprolol in heart failure due to myocardial infarction
Authors: Babick Andrea , Elimban Vijayan , Zieroth Shelley , Dhalla Naranjan S. 
Published: April 2013

AbstractIn order to examine the reversibility of heart failure due to myocardial infarction (MI) by β‐adrenoceptor blockade, 12 weeks infarcted rats were treated with or without metoprolol (50 mg/kg/day) for 8 weeks. The depressed left ventricular (LV) systolic pressure, positive and negative rates of changes in pressure development, ejection fraction, fractional shortening and cardiac output, as well as increased LV end‐diastolic pressure in 20 weeks MI animals were partially reversed by metoprolol. MI‐induced decreases in septum (systolic) thickness as well as increase in LV posterior wall thickness and LV internal diameter were partially or fully reversible by metoprolol. Treatment of MI animals with metoprolol partially reversed the elevated levels of plasma norepinephrine and dopamine without affecting the elevated levels of epinephrine. Although sarcoplasmic reticular (SR) Ca2+‐uptake, as well as protein content for SR Ca2+‐pump and phospholamban, were reduced in the infarcted hearts; these changes were partially reversible with metoprolol. Depressed myofibrillar Ca2+‐stimulated ATPase activity, as well as mRNA levels for SR Ca2+‐pump, phospholamban and α‐myosin heavy chain, were unaffected whereas increased mRNA level for β‐myosin heavy chain was partially reversed by metoprolol. The results suggest that partial improvement of cardiac performance by β‐adrenoceptor blockade at advanced stages of heart failure may be due to partial reversal of changes in SR Ca2+‐pump function whereas partial to complete reverse cardiac remodeling may be due to partial reduction in the elevated levels of plasma catecholamines. J. Cell. Physiol. 228: 2063–2070, 2013. © 2013 Wiley Periodicals, Inc.
Hybrid vapor stripping–vapor permeation process for recovery and dehydration of 1‐butanol and acetone/butanol/ethanol from dilute aqueous solutions. Part 2. Experimental validation with simple mixtures and actual fermentation broth
Authors: Vane Leland M. , Alvarez Franklin R. , Rosenblum Laura , Govindaswamy Shekar 
Published: April 2013

AbstractBACKGROUNDIn Part1 of this work, a process integrating vapor stripping, vapor compression, and a vapor permeation membrane separation step, ‘membrane assisted vapor stripping’ (MAVS), was predicted to produce energy savings compared with traditional distillation systems for separating 1‐butanol/water and acetone‐butanol‐ethanol/water (ABE/water) mixtures. Here, the separation performance and energy usage of a MAVS pilot system with such mixtures and an ABE fermentation broth were assessed.ResultsThe simple stripping process required 10.4 MJ‐fuel kg–1‐butanol to achieve 85% butanol recovery from a 1.3 wt% solution. Addition of the vapor compressor and membrane unit and return of the membrane permeate to the column raised 1‐butanol content from 25 wt% in the stripping vapor to 95 wt% while cutting energy usage by 25%. Recovery of secondary fermentation products from the ABE broth were based on their relative vapor–liquid partitioning. All volatilized organic compounds were concentrated to roughly the same degree in the membrane step. Membrane permeance, selectivity, and overall MAVS energy usage were the same with the broth as with the ABE/water solution.ConclusionEnergy usage of the MAVS experimental unit corroborated process simulation predictions. Simulations of more advanced MAVS designs predict 74% energy savings compared with a distillation–decanter system. Published 2013. This article is a U.S. Government work and is in the public domain in the USA
Sub‐Functionalization of Duplicated Genes in the Evolution of Nine‐Spined Stickleback Hatching Enzyme
Authors: Kawaguchi Mari , Takahashi Hiroshi , Takehana Yusuke , Naruse Kiyoshi , Nishida Mutsumi , Yasumasu Shigeki 
Published: April 2013

AbstractGene duplication is the primary source of novel genes, and is followed by non‐, sub‐, or neo‐functionalization. In this study, we compared the egg envelope digestion mechanism of hatching enzymes between three‐spined stickleback and nine‐spined stickleback species, and found that the function of the hatching enzymes of nine‐spined sticklebacks was uniquely derived by gene duplication, followed by sub‐functionalization. The hatching enzyme of euteleosts consists of two metalloproteases, high choriolytic enzyme (HCE), and low choriolytic enzyme (LCE). LCE, especially, has an important role in solubilizing egg envelope protein by cleaving two specific sites. Three‐spined stickleback had a single copy of the LCE gene, like other euteleosts. However, nine‐spined stickleback had two types of LCE genes, α‐type and β‐type, suggesting that a duplication of the LCE gene occurred during the evolution of sticklebacks. The α‐type and β‐type each cleaved one of the two sites. Therefore, in the nine‐spined stickleback, the function of the ancestral LCE was driven by a single copy gene, which was partitioned into two functions separately driven by two duplicated genes, and egg envelope was solubilized by the cooperative action of the two LCEs, α‐type and β‐type. Herein, we provide a molecular mechanism for an evolutionary adaptation driven by gene duplication and sub‐functionalization. J. Exp. Zool. (Mol. Dev. Evol.) 320B:140–150, 2013. © 2013 Wiley Periodicals, Inc.
Constructive Leader Behaviors, Likelihood of Derailment, and the Cuboid Personality Framework: A Replication and Extension of Gough (1990)
Authors: Kulas John T. 
Published: April 2013

AbstractGough (1990b) applied the California Psychological Inventory's (CPI) “cuboid” framework to various leadership contexts, noting the potential for continued, future application of this model within the leadership domain. However, subsequent to this initial investigation (and one similarly oriented but differently executed project), no cuboid follow‐up has taken place. Applying the framework to a large sample of international managers, cuboid classifications were recorded across cultural regions, gender, race, age, organizational level, and industry. Associations with indices of leadership effectiveness and derailment were documented via averaged 360° ratings. Results generally support norm‐favoring individuals as exhibiting leadership advantage, although this effect differed slightly across the leadership dimension being assessed (although remaining relatively stable across hierarchical leadership position). Potential future applications of the cuboid model to the management and leadership domains are suggested primarily in the topical areas of cross‐cultural leadership (different occupancy rates were documented across regions of origin), leadership emergence (interpersonally oriented, norm‐favoring individuals predominantly occupied leadership positions), and leader development (low “satisfaction” and rule‐questioning leaders were generally rated as having lower effectiveness ratings and an increased likelihood of derailment).
Dale Carnegie's Leadership Principles: Examining the Theoretical and Empirical Support
Authors: Basford Tessa E. , Molberg Andrea 
Published: April 2013

AbstractDale Carnegie's best‐seller How to Win Friends & Influence People offers advice on leadership, interpersonal relationships, and persuasion. Though profoundly influential, Carnegie's self‐help book—including its nine guiding leadership principles—is based on anecdotes, case studies, and personal examples rather than empirical evidence. Examining the theoretical and empirical support behind Carnegie's leadership principles is essential for leaders to better understand whether to draw upon these principles and, if so, how and when to effectively use them in the workplace.
The Imperative of Education
Authors: Thomas Ted , Gentzler Kevin 
Published: April 2013

AbstractTeaching midgrade leaders at the Command and General Staff Officers Course (CGSOC) located in Ft. Leavenworth, Kansas, comes with many unique challenges. At CGSOC, students arrive having led soldiers in combat and having served in leadership positions in the United States Army for at least 10 years. When they walk into the classroom and see an instructor with a dress shirt and tie—not in a uniform—their immediate thought is, “What can this civilian teach me? I have fought in foreign lands and had to watch people die and lead soldiers through intensely difficult circumstances.” Through most of their careers, their approach to learning in Professional Military Education (PME) has been through training. CGSOC is the first time they experience learning from mostly an educational pedagogy as opposed to training. We focus on teaching how to think instead of what to think. At CGSOC we use an Experiential Learning Model (ELM), based on Kolb's Experiential Learning Theory. The ELM takes Kolb's experiential learning cycle and superimposes five steps on the preferred learning styles described by Kolb. We promote student‐to‐student dialogue, drawing out the experience resident in the classroom, and add leadership theory to reinforce the learning.
Health Care Educators: New Directions in Leadership Development
Authors: Hess Caryl 
Published: April 2013

AbstractFortune 500 companies have a competitive advantage in leadership development, whereas health care has lagged far behind. Physician leadership development, in particular, is a game changer for a closed staff, group practice that relies on a pipeline of physician leaders—such as the Cleveland Clinic. To address this leadership development gap in health care, the Cleveland Clinic Academy (CCA) was established in 2006. The academy is predicated on developing health care leaders with specific emphasis on physician leadership education using a competency‐based curriculum with value‐added components, including continuing medical education (CME) and master's of business administration (MBA) transfer credits. In the pioneering spirit of Dr. F. Mason Sones, the novel curriculum includes didactic learning, experiential immersion, and executive coaching, designed to promote physician career development, leadership potential, productivity and job satisfaction, and business acumen. The unique programs—54 stand‐alone courses, and customized programs such as Leading in Health Care, Staff Leadership Rotation, Samson Global Leadership Academy, Healthcare Finance and Accounting, and others—have affected individuals and patient care by reaching over 6,000 health care providers, including physicians from Cleveland Clinic, Bulgaria, France, Ireland, Japan, Qatar, UAE, India, Belgium, Saudi Arabia, Nigeria, Turkey, Dominican Republic, and throughout the United States. CCA provides a new direction in leadership development with an integrated competency‐based curriculum for physicians, nurses, and administrators.
Mind the Gaps: What Limits the Impact of Leadership Education
Authors: Conger Jay 
Published: April 2013

AbstractAlthough leadership education holds great promise for enhancing the effectiveness of individuals in their work lives, it is limited by certain critical shortcomings. Unless these are successfully addressed, the classroom experiences we create will not facilitate the transfer of useful learning and its application to the day‐to‐day challenges that leaders face. In this article, the author addresses three important gaps in our approaches: the reality gap, the skill intensive gap, and the application gap. The author illustrates how and why each gap creates barriers to the transfer of learning to individuals and to their work‐lives.