bluuebunny/crossref_metadata_2025_split huggingface dataset:
Drivers of high‐involvement consumers' intention to buy PDO wines: Valpolicella PDO case study
Authors: Capitello Roberta , Agnoli Lara , Begalli Diego 
Published: November 2015

AbstractBACKGROUNDThis study investigates whether different sensory profiles of wines belonging to the same Protected Designation of Origin (PDO) are perceived as different products by consumers. It identifies the drivers of consumers' intention to buy preferred wines. Descriptive sensory analysis, consumer tests and consumer interviews were conducted to reach research aims. To perform the consumer tests and interviews, 443 consumers participated in the survey. The tasted wines comprised five samples representative of Valpolicella PDO wine. Analysis of variance tests, principal component analysis and linear and logit regressions were employed to verify the research hypotheses.RESULTSThe results demonstrated: (1) different sensory profiles exist within the Valpolicella PDO wine; (2) these sensory profiles result in consumers having the perception of diversified products; (3) the perception of differences was less marked for consumers than for trained assessors due to the different weight attributed to visual, aroma and the taste/mouthfeel hedonic dimensions; and (4) consumers' liking, as well as general perceptions, attitudes, preferences, wine knowledge and experience, contribute to consumers' intentions to buy more than the socio‐demographic characteristics of consumers.CONCLUSIONThe analysis of the drivers of consumers' intention to buy certain PDO wines provides new marketing insights into the roles of intrinsic quality, preferences and consumers' subjective characteristics in market segmentation. © 2015 Society of Chemical Industry
Effect and mechanism of pyridoxamine on the lipid peroxidation and stability of polyunsaturated fatty acids in beef patties
Authors: Wong Daniel , Hu Xiaoqiang , Tao Ningping , Wang Xichang , Wang Mingfu 
Published: November 2015

AbstractBACKGROUNDLittle is known about how vitamins can affect the peroxidation and stability of polyunsaturated fatty acids in cooked foods. Thus the effects of 15 vitamins on toxic malondialdehyde (MDA) formation in cooked beef patties were examined with the application of solid phase extraction and thiobarbituric acid (TBA) analysis by HPLC‐DAD. The polyunsaturated fatty acid profiles in cooked beef patties treated with some vitamins were further compared with that of control sample (no vitamin addition) by GC‐MS analysis.RESULTSPyridoxamine, pyridoxine, retinoic acid, α‐tocopherol and L‐ascorbic acid exhibited significant effects lowering the amount of MDA. It was further discovered that retinoic acid, α‐tocopherol and l‐ascorbic acid could help preserve polyunsaturated fatty acids, while pyridoxamine addition actually showed no effect upon the retention of most of the tested polyunsaturated fatty acids, even lowering the content of arachidonic acid. Further LC‐MS analysis demonstrated that pyridoxamine could directly react with MDA via an addition reaction. The reaction involves a nucleophilic attack of pyridoxamine's free amine group on one of the aldehyde functional groups of MDA to form a new adduct, and may accelerate lipid peroxidation with the loss of more polyunsaturated fatty acids.CONCLUSIONSome vitamins may directly participate in lipid peroxidation and affect food quality. © 2015 Society of Chemical Industry
Modulation of Charge Density of Cationic Conjugated Polyelectrolytes for Improving the FRET‐Induced Sensory Signal with Enhanced On/Off Ratio
Authors: Jeong Ji‐Eun , Jung In Hwan , Kim Boram , Le Van Sang , Woo Han Young 
Published: November 2015

Three types of cationic polyfluorenes with a different number of ionic groups are synthesized to modulate their solubility in water and the interactions with anionic oligonucleotide probes (DNA‐C). Increasing the charge density improves the water‐solubility of conjugated polyelectrolytes (CPEs) but decreases its optical antenna effect in the electrostatic sensory platform (CPE/DNA‐C), resulting in low fluorescence resonance energy transfer (FRET) signal. With increasing charge density in CPE, the concentration of conjugated units in CPE/DNA‐C decreases at [+]:[−] = 1:1, after which little driving force is expected to bring positive CPEs and negative DNA‐C into close proximity for efficient FRET. CPF2 with 2 ionic groups (per repeat unit) and hydrophilic polyether side‐chains exhibits good water‐solubility and a higher FRET signal with an enhanced signal on/off ratio. In addition, the charge density in CPEs modulates the range of sensory responses by forming a tighter or weaker electrostatic CPE/DNA‐C complex, which perturbs the probe‐target binding interactions.
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Artifact‐suppressed optimal three‐dimensional T1‐ and T2*‐weighted dual‐echo imaging
Authors: Do Won‐Joon , Kim Ki Hwan , Choi Seung Hong , Park Sung‐Hong 
Published: November 2015

PurposeTo develop a new artifact‐suppressed optimal three‐dimensional (3D) T1‐ and T2*‐weighted dual‐echo imaging.MethodsWe optimized flip angles for 3D T1‐ and T2*‐weighted imaging by conventional dual‐echo in vivo experiments and computer simulations, and then implemented a dual‐echo sequence with an echo‐specific k‐space reordering scheme to satisfy the optimal flip angles for both T1 and T2* contrast. We also proposed two strategies to suppress ringing artifacts induced by the abrupt flip angle jumps in the proposed dual echo sequence: (i) implementing smooth transition regions and (ii) discarding the k‐space regions of the abrupt flip angle jumps as dummy phase‐encoding steps.ResultsThe optimal flip angles measured from experiments were different between T1‐ and T2*‐weighted contrast, in agreement with simulations. The echo‐specific k‐space reordered dual‐echo sequence showed optimal T1 and T2* contrast simultaneously, but also showed ringing artifacts because of high flip‐angle changes between k‐space regions. The two proposed strategies effectively suppressed the ringing artifacts.ConclusionThe proposed 3D dual‐echo sequence provided optimal T1 and T2* contrast simultaneously with no artifacts and thus is potentially applicable to routine clinical applications for simultaneous high resolution T1‐ and T2*‐weighted imaging. Magn Reson Med 76:1504–1511, 2016. © 2015 International Society for Magnetic Resonance in Medicine
Passende Kleider für Proteine schneidern
Authors: Wettig Burkhard , Heid Christian , Schrader Thomas 
Published: November 2015

AbstractNichtkovalente Wechselwirkungen zwischen Proteinen steuern viele Prozesse im menschlichen Körper. Maßgeschneiderte künstliche Liganden binden Proteine, hemmen so Enzyme oder machen Viren weniger infektiös.
Urheberrecht und gute wissenschaftliche Praxis
Authors: Schmitt Anne‐Marie 
Published: November 2015

AbstractDas Internet macht es möglich, geistige Inhalte schnell zu kopieren und zu verbreiten. Plagiatsaffären in den letzten Jahren haben aber gezeigt: Das kann böse Folgen haben. Das Urheberrechtsgesetz regelt, was erlaubt ist und was nicht.
Hybridnanomaterialien für die Elektrokatalyse
Authors: Herrmann Sven , Streb Carsten 
Published: November 2015

AbstractGebunden an organische Ankergruppen oder Nanokohlenstoff spalten Polyoxometallate Wasser, schützen Metalle vor Korrosion, detektieren Wasserstoff und bescheren uns in Zukunft vielleicht sogar neue Superkondensatoren.
Elearning approaches to prevent weight gain in young adults: A randomized controlled study
Authors: Nikolaou Charoula Konstantia , Hankey Catherine Ruth , Lean Michael Ernest John 
Published: November 2015

ObjectivePreventing obesity among young adults should be a preferred public health approach given the limited efficacy of treatment interventions. This study examined whether weight gain can be prevented by online approaches using two different behavioral models, one overtly directed at obesity and the other covertly.MethodsA three‐group parallel randomized controlled intervention was conducted in 2012–2013; 20,975 young adults were allocated a priori to one control and two “treatment” groups. Two treatment groups were offered online courses over 19 weeks on (1) personal weight control (“Not the Ice Cream Van,” NTICV) and, (2) political, environmental, and social issues around food (“Goddess Demetra,” “GD”). Control group received no contact. The primary outcome was weight change over 40 weeks.ResultsWithin‐group 40‐week weight changes were different between groups (P < 0.001): Control (n = 2,134): +2.0 kg (95% CI = 1.5, 2.3 kg); NTICV (n = 1,810): −1.0 kg (95% CI = −1.3, −0.5); and GD (n = 2,057): −1.35 kg (95% CI = −1.4 to −0.7). Relative risks for weight gain vs. control: NTICV = 0.13 kg (95% CI = 0.10, 0.15), P < 0.0001; GD = 0.07 kg (95% CI = 0.05, 0.10), P < 0.0001.ConclusionsBoth interventions were associated with prevention of the weight gain observed among control subjects. This low‐cost intervention could be widely transferable as one tool against the obesity epidemic. Outside the randomized controlled trial setting, it could be enhanced using supporting advertising and social media.
Active lifestyle in childhood and adolescence prevents obesity development in young adulthood
Authors: Kwon Soyang , Janz Kathleen F. , Letuchy Elena M. , Burns Trudy L. , Levy Steven M. 
Published: November 2015

ObjectiveTo test the hypothesis that individuals who are active but who decrease physical activity (PA) over time have a higher risk of becoming obese in young adulthood, when compared to individuals who are consistently active throughout childhood and adolescence.MethodsIowa Bone Development Study cohort members (242 males and 251 females) participated in accelerometry assessments, dual‐energy X‐ray absorptiometry scans, and dietary questionnaire surveys at ages 5, 8, 11, 13, 15, 17, and 19 years. Group‐based trajectory analyses identified distinct trajectory patterns of moderate‐ to vigorous‐intensity PA (MVPA), percentage of body fat, and energy intake. A multivariable logistic regression model was fit to estimate the odds of “becoming obese” based on the MVPA trajectories, adjusted for mother's education, somatic maturation, and energy intake.ResultsAmong males, 74.7% had a “normal” body fat pattern, 14.6% had a “becoming obese” pattern, and 10.7% had a “consistently obese” pattern, while among females, the percentages were 58.6%, 28.6%, and 12.8%, respectively. Participants who were active (≥45 min MVPA) as children but decreased MVPA with age were more likely to become obese, compared to consistently active participants (adjusted OR = 2.77; 95% CI = 1.16, 6.58).ConclusionsAn active lifestyle throughout childhood and adolescence could prevent obesity development in young adulthood.
miR‐27 impairs the adipogenic lineage commitment via targeting lysyl oxidase
Authors: Chen Su‐Zhen , Xu Xu , Ning Liu‐Fang , Jiang Wen‐Yan , Xing Chun , Tang Qi‐Qun , Huang Hai‐Yan 
Published: November 2015

ObjectiveThe recruitment and commitment of mesenchymal stem cells and their terminal differentiation into adipocytes are the main pathways for increasing adipocyte cell numbers during obesity. Our previous studies have shown that lysyl oxidase (Lox) is upregulated and functions as an essential factor during bone morphogenetic protein 4 (BMP4) ‐induced C3H10T1/2 cell adipocytic lineage commitment. However, the mechanism of Lox regulation during adipogenic lineage commitment has remained largely unestablished.MethodsSamples of adipose tissue from humans with different BMI and C57BL/6 mice with a high‐fat diet were used to compare microRNA‐27 (miR‐27) expression level associated with obesity. Taqman assays were used for miR‐27 expression detection and Oil Red O staining for adipogenesis analysis.ResultsA negative correlation was identified between Lox expression level and miR‐27 expression in both BMP4‐treated C3H10T1/2 cells and human subcutaneous adipose tissues. A Lox 3′ UTR luciferase reporter assay showed that miR‐27 directly targeted Lox. Furthermore, overexpression of miR‐27 impaired BMP4‐induced upregulation of Lox and adipocytic commitment, which could be rescued by overexpression of mature Lox. Conversely, miR‐27 inhibition by specific inhibitors increased Lox expression and adipocytic commitment.ConclusionsTaken together, these results suggest a novel role for miR‐27 in repressing adipogenic lineage commitment by targeting Lox.
Survey of the Definition of Fetal Viability and the Availability, Indications, and Decision Making Processes for Post‐Viability Termination of Pregnancy for Fetal Abnormalities and Health Conditions in Canada
Authors: Hull Danna , Davies Gregory , Armour Christine M. 
Published: November 2015

AbstractThe purpose of this study was to explore the definition of fetal viability and the availability, indications, and decision making processes for post‐viability termination of pregnancy for fetal abnormalities and health conditions in Canada. An online survey of members of the Canadian Association of Genetic Counsellors, the Canadian College of Medical Geneticists, and the Canadian Society for Maternal‐Fetal Medicine who provide direct counselling to, or management of, prenatal patients in Canada (total sample size 815). Results of this study showed that the majority of respondents indicated that their centre will offer post‐viability termination of pregnancy (98/123; 80 %). Sixty‐seven percent (68/101) of respondents reported the definition of fetal viability to be 24 weeks’ gestation. Most respondents reported that a collaborative decision making process was used to determine if post‐viability termination of pregnancy would be offered (136/170; 80 %). For conditions presumed to be lethal/likely lethal, the majority of respondents would “sometimes” or “always” offer post‐viability termination of pregnancy, whereas for conditions presumed to have a mild effect, the majority of respondents would “rarely” or “never” offer post‐viability termination of pregnancy. Ninety percent (77/86) of respondents reported that perinatal hospice is offered as an alternative to termination of pregnancy. In conclusion, this study suggests that although post‐viability termination is available in many provinces in Canada, variation in the definition of fetal viability and indications appear to exist. While these variations may lead to unequal access to post‐viability termination of pregnancy across Canada, they might also represent the complexity of the decision making process and the importance of examining individual factors to ensure that the most appropriate decision is made in each case.
Determination of Acylglycerols and Glycerol in Castor:Soybean Biodiesel Blend Produced by a Base/Acid‐Catalyzed Process
Authors: de Moura Renata Rodrigues , Dias Adriana Neves , de Freitas Granjão Vinícius , Primel Ednei Gilberto , D’Oca Marcelo Gonçalves Montes 
Published: November 2015

AbstractThis paper describes the production of the methyl biodiesel blend of hydroxylated vegetable (castor oil) and soybean oils by a base/acid‐catalyzed process and the first simultaneous determination by gas chromatography of the levels of total and free glycerol, mono‐, di‐ and triacylglycerols based on the standard method ASTM D 6584. Best results were observed for transesterification carried out in 6:1 (methanol:oil), sodium hydroxide 1 % w/w at 60 °C for 1.5 h. The analytical method not only produced curves with good linearity, but also had a coefficient of determination (r2) above 0.997 and accuracy between 70 and 141 % at relative standard deviations (RSD) lower than 10 %. The matrix effect (ME) was investigated and only diolein was found to have a significant matrix effect. The method was robust when applied to different chemical compositions of biodiesel. Results showed that the acid value and the contents of mono‐, di‐, and triacylglycerols, total and free glycerol were within the limits set by standardized methods and that biodiesel may be produced from soybean and castor oil blends.
ISDN2014_0027: REMOVED: Identification of a unique molecular and functional microglia signature in health and disease
Authors: Butovsky Oleg , Jedrychowski Mark P. , Moore Craig S. , Cialic Ron , Lanser Amanda J. , Gabriely Galina , Koeglsperger Thomas , Dake Ben , Wu Pauline M. , Doykan Camille E. , Fanek Zain , Liu LiPing , Chen Zhuoxun , Rothstein Jeffrey D. , Ransohoff Richard M. , Gygi Steven P. , Antel Jack P. , Weiner Howard L. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
Antibodies from combinatorial libraries use functional receptor pleiotropism to regulate cell fates
Authors: Lerner Richard A. , Grover Rajesh K. , Zhang Hongkai , Xie Jia , Han Kyung Ho , Peng Yingjie , Yea Kyungmoo 
Published: November 2015

AbstractTo date, most antibodies from combinatorial libraries have been selected purely on the basis of binding. However, new methods now allow selection on the basis of function in animal cells. These selected agonist antibodies have given new insights into the important problem of signal transduction. Remarkably, when some antibodies bind to a given receptor they induce a cell fate that is different than that induced by the natural agonist to the same receptor. The fact that receptors can be functionally pleiotropic may yield new insights into the important problem of signal transduction.
A triazole linkage that mimics the DNA phosphodiester group in living systems
Authors: El-Sagheer Afaf H. , Brown Tom 
Published: November 2015

AbstractWe describe the development of a chemical process based on the CuAAC reaction (click chemistry) to ligate DNA strands and produce an unnatural triazole backbone linkage. The chemical reaction is templated by a complementary DNA splint which accelerates the reaction and provides the required specificity. The resultant 1,4-triazole linkage is read through by DNA and RNA polymerases and is biocompatible in bacterial and human cells. This work has implications for the synthesis of chemically modified genes and other large modified DNA and RNA constructs.
Survey about citation context analysis: Tasks, techniques, and resources
Authors: HERNÁNDEZ-ALVAREZ MYRIAM , GOMEZ JOSÉ M. 
Published: November 2015

AbstractBibliometric calculations currently used to assess the quality of researchers, articles, and scientific journals have serious structural problems; many authors have noted the weakness of citation counts, because they are purely quantitative and do not differentiate between high- and low-citing papers. If a paper’s reputation is simply evaluated according to the number of its citations, then incomplete, incorrect, or controversial articles may be promoted, regardless of their relevancy. Therefore, perverse incentives are generated for researchers who may publish many incorrect or incomplete papers to achieve high impact indexes. It is essential to improve the objective criteria for automatic article-quality assessments. However, to obtain these new criteria, it is necessary to advance the programmed detection of context, polarity, and function of bibliographic references.We present an overview of general concepts and review contributions to the solutions to problems related to these issues, with the purpose of identifying trends and suggesting possible future research directions.
Treating your worst nightmare: a case-series of imagery rehearsal therapy for nightmares in individuals experiencing psychotic symptoms
Authors: Sheaves Bryony , Onwumere Juliana , Keen Nadine , Kuipers Elizabeth 
Published: November 2015

AbstractPrevious research has indicated that nightmares might be a common problem for people with psychotic symptoms. Furthermore, more distressing nightmares have been associated with higher levels of delusional severity, depression, anxiety, stress and working memory. However no known research has investigated the use of nightmare treatments in those with symptoms of psychosis. This study aimed to assess the acceptability and feasibility of using imagery rehearsal (IR) therapy as a treatment of nightmares for those presenting with co-morbid psychotic symptoms. Six participants presenting with frequent distressing nightmares and psychotic symptoms were recruited. Five participants attended 4–6 sessions of IR. Measures of nightmares, sleep quality, psychotic and affective symptoms were completed at baseline and immediately following the intervention. It was feasible to adapt IR for those experiencing psychotic symptoms. Descriptive improvements were noted on measures of nightmare-related distress, vividness and intensity. Positive post-session feedback endorsed the acceptability of IR. Nightmare frequency did not reduce following IR; however, participants described a change in emotional response. IR was an acceptable and feasible intervention for this small sample. A larger study powered to detect group changes, with an additional control is warranted to test the efficacy of the intervention for those with psychosis.
Zur Erfassung und Validierung akkommodativer Bewältigungsfähigkeiten im Grundschulalter
Authors: Lessing Nora , Mähler Claudia , Greve Werner 
Published: November 2015

Zusammenfassung. Akkommodative Prozesse, die im Sinne der Bewältigungstheorie des Zwei-Prozess-Modells über die Lebensspanne auf flexible Zielanpassungs- bzw. nicht intentionale Zielabwertungsprozesse fokussieren, sind bislang vorwiegend im Erwachsenenalter auf der Basis von Selbstauskunft (Fragebogen) untersucht worden. Insbesondere für das Kindesalter gibt es keinerlei Studien über akkommodative Bewältigungsressourcen. In Studie 1 (N = 38; 7 bis 8 Jahre) wurde ein Instrument entwickelt, das auf altersgerecht spielerische Weise Zielab- sowie -aufwertungsprozesse erfasst. In einer Experimentalbedingung wurden zuvor induzierte Ziele blockiert–die Kinder dieser Gruppe unterschieden sich signifikant in ihren Ausprägungen der Zielabwertung sowie in der Aufwertung alternativer Ziele von der Kontrollbedingung. In Studie 2 (N = 85) wurde das Erhebungsinstrument aus Studie 1 bei 7- bis 8-jährigen Kindern verwendet und im Fremdurteil der Eltern empirisch validiert. Beide Befundmuster stützen die These, dass das vorgelegte Instrument zur Messung akkommodativer Prozesse im Grundschulalter geeignet ist.
Downregulation of miR-320a/383-sponge-like long non-coding RNA NLC1-C (narcolepsy candidate-region 1 genes) is associated with male infertility and promotes testicular embryonal carcinoma cell proliferation
Authors: Lü M , Tian H , Cao Y-x , He X , Chen L , Song X , Ping P , Huang H , Sun F 
Published: November 2015

AbstractLong non-coding RNAs (lncRNAs), which are extensively transcribed from the genome, have been proposed to be key regulators of diverse biological processes. However, little is known about the role of lncRNAs in regulating spermatogenesis in human males. Here, using microarray technology, we show altered expression of lncRNAs in the testes of infertile men with maturation arrest (MA) or hypospermatogenesis (Hypo), with 757 and 2370 differentially down-regulated and 475 and 163 up-regulated lncRNAs in MA and Hypo, respectively. These findings were confirmed by quantitative real-time PCR (qRT-PCR) assays on select lncRNAs, including HOTTIP, imsrna320, imsrna292 and NLC1-C (narcolepsy candidate-region 1 genes). Interestingly, NLC1-C, also known as long intergenic non-protein-coding RNA162 (LINC00162), was down-regulated in the cytoplasm and accumulated in the nucleus of spermatogonia and primary spermatocytes in the testes of infertile men with mixed patterns of MA compared with normal control. The accumulation of NLC1-C in the nucleus repressed miR-320a and miR-383 transcript and promoted testicular embryonal carcinoma cell proliferation by binding to Nucleolin. Here, we define a novel mechanism by which lncRNAs modulate miRNA expression at the transcriptional level by binding to RNA-binding proteins to regulate human spermatogenesis.