bluuebunny/crossref_metadata_2025_split huggingface dataset:
The positive impact of identity-affirming mental health treatment for neurodivergent individuals
Authors: Kroll Elizabeth , Lederman Megan , Kohlmeier Jonathan , Kumar Komal , Ballard Jaime , Zant Izabella , Fenkel Caroline 
Published: July 2024

IntroductionThe medical and social definitions of neurodivergence have become a common topic of discussion in recent years, and the ways that we define, measure and report on conditions within the neurodivergent umbrella are changing. The objective of this study was to analyze differences in mental health symptom presentation at intake and compare treatment outcomes among three groups: clients with an affirming neurodivergent diagnosis, clients without an affirming diagnosis, and neurotypical clients.MethodsData were collected at intake and discharge. Clients self-reported neurodivergent identity, neurodivergent diagnoses, as well as the severity of depression symptoms, anxiety symptoms and self-harm frequency. One-way multivariate analysis of variance tests were run to assess differences in mental health symptoms at intake and discharge based on neurodivergent identity and corresponding diagnosis. When MANOVAs indicated significant differences, follow-up univariate one-way ANOVAs were conducted for each dependent variable.ResultsNeurodivergent clients reported significantly worse mental health symptoms at intake than neurotypical clients, regardless of diagnosis status. Additionally, clients who identified as neurodivergent but did not report an affirming medical diagnosis reported significantly worse mental health symptoms than those who did report an affirming medical diagnosis. By discharge from IOP treatment, no significant differences were found in symptom change scores between neurodivergent and neurotypical individuals, or neurodivergent individuals with an affirming diagnosis and those without.DiscussionThese findings highlight the importance of acknowledging client identity as a key component of mental health treatment. The act of validating symptoms and experiences, allowing accommodations when requested, and exploring identity formation regardless of diagnosis, allowed all clients who identified as neurodivergent to benefit from treatment.
Associations of exposure to volatile organic compounds with sleep health and potential mediators: analysis of NHANES data
Authors: Zhuang Yan , Li Laifu , Zhang Yanqi , Dai Fei 
Published: July 2024

ObjectiveThe effect of environmental pollution on sleep has been widely studied, yet the relationship between exposure to volatile organic compounds (VOCs) and sleep health requires further exploration. We aimed to investigate the single and mixed effect of urinary VOC metabolites on sleep health and identify potential mediators.MethodsData for this cross-sectional study was collected from the National Health and Nutrition Examination Surveys (NHANES) (2005–2006, 2011–2014). A weighted multivariate logistic regression was established to explore the associations of 16 VOCs with four sleep outcomes. Following the selection of important VOCs through the least absolute shrinkage and selection operator (LASSO) regression, principal component analyses (PCA), weight quantile sum (WQS), and Bayesian kernel machine regression (BKMR) analyses were conducted to explore the associations between exposure to single and mixed VOCs and sleep outcomes, as well as identify the most contributing components. A mediation analysis was performed to explore the potential effect of depression scores.ResultsOf the 3,473 participants included in the study, a total of 618 were diagnosed with poor sleep patterns. In logistic regression analyses, 7, 10, 1, and 5 VOCs were significantly positively correlated with poor sleep patterns, abnormal sleep duration, trouble sleeping, and sleep disorders, respectively. The PCA analysis showed that PC1 was substantially linked to a higher risk of poor sleep patterns and its components. The WQS model revealed a positive association between VOC mixture of increased concentrations and poor sleep patterns [OR (95% CI): 1.285 (1.107, 1.493)], abnormal sleep duration [OR (95% CI): 1.154 (1.030, 1.295)], trouble sleeping [OR (95% CI): 1.236 (1.090, 1.403)] and sleep disorders [OR (95% CI): 1.378 (1.118, 1.705)]. The BKMR model found positive associations of the overall VOC exposure with poor sleep patterns, trouble sleeping, and sleep disorders. PCA, WQS, and BKMR models all confirmed the significant role of N-acetyl-S-(N-methylcarbamoyl)-l-cysteine (AMCC) in poor sleep patterns and its components. The depression score was a mediator between the positive VOC mixture index and the four sleep outcomes.ConclusionExposure to single and mixed VOCs negatively affected the sleep health of American population, with AMCC playing a significant role. The depression score was shown to mediate the associations of VOC mixtures with poor sleep patterns and its components.
Developing a person-centered stated preference survey for dementia with Lewy bodies: value of a personal and public involvement process
Authors: Donnelly Paula Sinead , Sweeney Aoife , Wilson Emily , Passmore Anthony Peter , McCorry Noleen K. , Boeri Marco , Kane Joseph P. M. 
Published: July 2024

IntroductionThe development of high-quality stated preference (SP) surveys requires a rigorous design process involving engagement with representatives from the target population. However, while transparency in the reporting of the development of SP surveys is encouraged, few studies report on this process and the outcomes. Recommended stages of instrument development includes both steps for stakeholder/end-user engagement and pretesting. Pretesting typically involves interviews, often across multiple waves, with improvements made at each wave; pretesting is therefore resource intensive. The aims of this paper are to report on the outcomes of collaboration with a Lewy body dementia research advisory group during the design phase of a SP survey. We also evaluate an alternative approach to instrument development, necessitated by a resource constrained context.MethodThe approach involved conducting the stages of end-user engagement and pretesting together during a public involvement event. A hybrid approach involving a focus group with breakout interviews was employed. Feedback from contributors informed the evolution of the survey instrument.ResultsChanges to the survey instrument were organized into four categories: attribute modifications; choice task presentation and understanding; information presentation, clarity and content; and best-best scaling presentation. The hybrid approach facilitated group brainstorming while still allowing the researcher to assess the feasibility of choice tasks in an interview setting. However, greater individual exploration and the opportunity to trial iterative improvements across waves was not feasible with this approach.DiscussionInvolvement of the research advisory group resulted in a more person-centered survey design. In a context constrained by time and budget, and with consideration of the capacity and vulnerability of the target population, the approach taken was a feasible and pragmatic mechanism for improving the design of a SP survey.
The impact of digital literacy on farmers' pro-environmental behavior: an analysis with the Theory of Planned Behavior
Authors: Lu Shen , Sun Zenan , Huang Man 
Published: July 2024

IntroductionThe rapid development of agriculture has brought about significant negative impacts on the environment, such as land pollution and ecological degradation. The root cause of environmental issues lies in human behavior, with improper farming practices by farmers being a major contributor to agricultural pollution. This paper explores the relationship between farmers' digital literacy and their pro-environmental behaviors, examining the mediating roles of subjective norms, behavioral attitudes, and perceived behavioral control. Additionally, it investigates the varying impacts of digital literacy on PEB among farmers with different levels of education, social capital, and household income.MethodsBased on data from the China Land Economic Survey (CLES), this study utilizes an ordered probit regression analysis method to analyze data from 923 sample respondents in 24 villages in Jiangsu Province. All analyses were conducted using Stata 15.0.ResultsThe research findings indicate that digital literacy enhances the likelihood of farmers engaging in PEB. This practice is achieved by reinforcing farmers' subjective norms, strengthening their behavioral attitudes, and enhancing their perceived behavioral control (as the core elements in the Theory of Planned Behavior theory), thereby promoting the implementation of PEB among farmers. Further analysis reveals that digital literacy plays a crucial role in enhancing PEB among farmers with higher levels of education, social capital, and household income.DiscussionThe results of this study suggest that policymakers should enhance farmers' digital literacy and implement specific measures to improve farmers' subjective norms, behavioral attitudes, and perceived behavioral control. When the digital literacy and willingness for PEB are improved, farmers may engage in environmentally friendly practices.
Insights into the cashew production system in Guinea-Bissau: implications for agroecosystem sustainability
Authors: Sierra-Baquero Paola , Catarino Sílvia , Costa Gonçalo João , Barai Amidu , Correia Zinha , Ferreira Maria Rosa , Varón-Devia Edgar , Romeiras Maria M. , Catarino Luís , Duarte Maria Cristina , Monteiro Filipa 
Published: July 2024

IntroductionWest Africa, particularly Guinea-Bissau, heavily relies on cashew nut (Anacardium occidentale L.) production, which significantly impacts the countries’ economies. Cashew exhibits remarkable adaptability to impoverished and arid soils. Understanding producers’ socio-economic characteristics is crucial due to their potential influence on crop productivity and household income.MethodsThis study aims to characterize the socio-economic, productive, and phytosanitary aspects of cashew production in Guinea-Bissau, through 151 interviews with producers across all administrative regions of the country.ResultsOur findings reveal that cashew producers are mainly males aged 40 to 60, they typically manage plantations under 5 ha, with the smaller plantation areas located in Gabú, Cacheu, and Bolama. The age of the older trees averaged 31 years, with the highest age found in Biombo. Tree density averaged 286 trees per hectare, with higher values in Cacheu, Bafatá, and Bolama. Cashew nut yield in 2020 averaged less than 0.5 tons per hectare, with farmer-set prices generally lower than government determined prices. Oio, Tombali, and Bolama were the regions most affected by pests, while Oio and Cacheu (North) were the most affected by diseases. Top pests included termites, branch girdler, weaver ants, African grasshopper, and stem borer; while top diseases comprised gummosis, anthracnose, and dieback.DiscussionCharacterization of cashew production system is crucial at both national and regional levels to identify region-specific limitations and strengths, aiding in the formulation of tailored strategies for sustainable production. Moreover, cashew production plays a crucial role in household incomes in Guinea-Bissau, underscoring the necessity of developing integrated management strategies.
Many human pharmaceuticals are weak inhibitors of the cytochrome P450 system in rainbow trout (Oncorhynchus mykiss) liver S9 fractions
Authors: Pihlaja Tea , Oksanen Timo , Vinkvist Netta , Sikanen Tiina 
Published: July 2024

IntroductionPharmaceutical residues are widely detected in aquatic environment and can be taken up by nontarget species such as fish. The cytochromes P450 (CYP) represent an important detoxification mechanism in fish, like in humans. In the present study, we assessed the correlation of the substrate selectivities of rainbow trout CYP1A and CYP3A homologues with those of human, through determination of the half-maximal inhibitory concentrations (IC50) of a total sixteen human pharmaceuticals toward CYP1A-like ethoxyresorufin O-deethylase (EROD) and CYP3A-like 7-benzyloxy-4-trifluoromethylcoumarin O-debenzylase (BFCOD) in rainbow trout (Oncorhynchus mykiss) liver S9 fractions (RT-S9).MethodsThe inhibitory impacts (IC50) of atomoxetine, atorvastatin, azelastine, bimatoprost, clomethiazole, clozapine, desloratadine, disulfiram, esomeprazole, felbinac, flecainide, orphenadrine, prazosin, quetiapine, sulpiride, and zolmitriptan toward the EROD and BFCOD activities in RT-S9 were determined using the IC50 shift assay, capable of identifying time-dependent inhibitors (TDI). Additionally, the nonspecific binding of the test pharmaceuticals to RT-S9 was assessed using equilibrium dialysis.ResultsMost test pharmaceuticals were moderate to weak inhibitors of both EROD and BFCOD activity in RT-S9, even if most are noninhibitors of human CYP1A or CYP3A. Only bimatoprost, clomethiazole, felbinac, sulpiride, and zolmitriptan did not inhibit either activity in RT-S9. EROD inhibition was generally stronger than that of BFCOD and some substances (atomoxetine, flecainide, and prazosin) inhibited selectively only EROD activity. The strongest EROD inhibition was detected with azelastine and esomeprazole (unbound IC50 of 3.8 ± 0.5 µM and 3.0 ± 0.8 µM, respectively). None of the test substances were TDIs of BFCOD, but esomeprazole was a TDI of EROD. Apart from clomethiazole and disulfiram, the nonspecific binding of the test pharmaceuticals to the RT-S9 was extensive (unbound fractions &lt;0.5) and correlated well (R2 = 0.7135) with their water-octanol distribution coefficients.DiscussionThe results indicate that the P450 interactions in RT-S9 cannot be explicitly predicted based on human data, but the in vitro data reported herein can shed light on the substrate selectivity of rainbow trout CYP1A1 and CYP3A27 in comparison to their human homologues. The IC50 concentrations are however many orders of magnitude higher than average environmental concentrations of pharmaceuticals. The time-dependent EROD inhibition by esomeprazole could warrant further research to evaluate its possible interlinkages with hepatotoxic impacts on fish.
Antimicrobial Activity of Water-Soluble Silver Complexes Bearing C-Scorpionate Ligands
Authors: Mahmoud Abdallah G. , Sousa Sílvia A. , Guedes da Silva M. Fátima C. , Martins Luísa M. D. R. S. , Leitão Jorge H. 
Published: July 2024

The novel hydrosoluble silver coordination polymer [Ag(NO3)(μ-1κN;2κN′,N″-TPMOH)]n (1) (TPMOH = tris(1H-pyrazol-1-yl)ethanol) was obtained and characterized. While single crystal X-ray diffraction analysis of compound 1 disclosed an infinite 1D helical chain structure in the solid state, NMR analysis in polar solvents confirmed the mononuclear nature of compound 1 in solution. Compound 1 and the analogue [Ag(μ-1κN;2κN′,N″-TPMS)]n (2) (TPMS = tris(1H-pyrazol-1-yl)methane sulfonate) were evaluated with regard to their antimicrobial activities towards the Gram-negative Escherichia coli, Pseudomonas aeruginosa, and Burkholderia contaminans, the Gram-positive Staphylococcus aureus, and the fungal species Candida albicans and Candida glabrata. Compound 1 exhibited minimal inhibitory concentration (MIC) values ranging from 2 to 7.7 µg/mL towards the tested Gram-negative bacteria, 18 µg/mL towards the Gram-positive S. aureus, and 15 and 31 µg/mL towards C. albicans and C. glabrata, respectively. Compound 2 was less effective towards the tested bacteria, with MIC values ranging from 15 to 19.6 µg/mL towards the Gram-negative bacteria and 51 µg/mL towards S. aureus; however, it was more effective against C. albicans and C. glabrata, with MIC values of about 6 µg/mL towards these fungal species. The toxicity of compounds 1 and 2 was assessed by evaluating the survival of the Caenorhabditis elegans model organism to concentrations of up to 100 µg/mL. The value of 50% lethality (LD50) could only be estimated as 73.2 µg/mL for compound 1 at 72 h, otherwise LD50 was >100 µg/mL for both compounds 1 and 2. These results indicate compounds 1 and 2 as novel silver complexes with interesting antimicrobial properties towards bacterial and fungal pathogens.
Electrocatalytic Hydrogen Evolution Reaction of Cobalt Triaryl Corrole Bearing Nitro Group
Authors: Zeng Jie , Cao Xu-You , Xu Shi-Yin , Qiu Yi-Feng , Chen Jun-Ying , Si Li-Ping , Liu Hai-Yang 
Published: July 2024

The use of non–precious metals for electrocatalytic hydrogen reaction (HER) is particularly important for energy conservation and environmental protection. In this work, three new cobalt corroles containing o−, m−, and p−nitrobenzyl (1, 2, 3) at the meso 10−position of the corrole macrocycle were synthesized, and their electrocatalytic hydrogen evolution reaction in organic and neutral aqueous systems was also investigated. The results show that these three cobalt corroles have significant catalytic HER activity in both systems, and the catalytic efficiency follows 1 > 3 > 2, which indicates that the position of the nitro group can affect the catalytic property of the complexes. In the organic phase, when using trifluoroacetic acid or p−toluenesulfonic acid as the proton source, the electrocatalytic HER may undergo an EECC (E: electron transfer, C: proton coupling) pathway. In a neutral aqueous system, the HER turnover frequency value of 1 is up to 137.4 h−1 at 938 mV overpotential.
The Food Source and Gut Bacteria Show Effects on the Invasion of Alien Pests—A Case of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae)
Authors: Zhu Yanfei , Han Rui , Zhang Tong , Yang Jiawen , Teng Ziwen , Fan Yinjun , Sun Pengdong , Lu Yongyue , Ren Yonglin , Wan Fanghao , Zhou Hongxu 
Published: July 2024

How alien pests invade new areas has always been a hot topic in invasion biology. The spread of the Bactrocera dorsalis from southern to northern China involved changes in food sources. In this paper, in controlled conditions, we take Bactrocera dorsalis as an example to study how plant host transformation affects gut bacteria by feeding it its favorite host oranges in the south, its favorite host peaches and apples in the north, and feeding it cucumbers as a non-favorite host plant, thereby further affecting their fitness during invasion. The result showed that, after three generations of feeding on cucumbers, Bactrocera dorsalis took longer to develop as a larva while its longevity and fecundity decreased and pre-adult mortality increased. Feeding it cucumbers significantly reduced the overall diversity of gut microbiota of Bactrocera dorsalis. The relative abundance of Enterobacter necessary for survival decreased, while the Empedobacter and Enterococcus increased, resulting in decreased carbohydrate transport and metabolism and increased lipid transport and metabolism. Feeding Bactrocera dorsalis Empedobacter brevis and Enterococcus faecalis resulted in a 26% increase in pre-adult mortality and a 2–3 d increase in adult preoviposition period (APOP). Additionally, Enterococcus faecalis decreased the longevity of female and male adults by 17 and 12 d, respectively, and decreased fecundity by 11%. We inferred that the shifted plant hosts played an important role in posing serious harm to Bactrocera dorsalis invading from the south to the north. Therefore, after an invasion of Bactrocera dorsalis into northern China, it is difficult to colonize cucumbers for a long time, but there is still a risk of short-term harm. The findings of this study have established that the interactions between an insect’s food source and gut bacteria may have an important effect on insect invasions.
The Genomic Epidemiology of Clinical Burkholderia pseudomallei Isolates in North Queensland, Australia
Authors: Gassiep Ian , Chatfield Mark D. , Permana Budi , Burnard Delaney , Bauer Michelle J. , Cuddihy Thom , Forde Brian M. , Mayer-Coverdale Johanna , Norton Robert E. , Harris Patrick N. A. 
Published: July 2024

Background: Burkholderia pseudomallei, the causative agent of melioidosis, is highly genetically recombinant, resulting in significant genomic diversity. Multiple virulence factors have been associated with specific disease presentations. To date, there are limited data relating to genomic diversity and virulence factors associated with melioidosis cases in North Queensland, Australia. Aim: To describe the genetic diversity of B. pseudomallei and identify virulence factors associated with clinical risk factors and patient outcomes. Methods: Whole genome sequencing of clinical isolates was performed and analysed with clinical data obtained from a retrospective melioidosis cohort study. Results: Fifty-nine distinct sequence types (STs) were identified from the 128 clinical isolates. Six STs comprised 64/128 (50%) isolates. Novel STs accounted for 38/59 (64%) STs, with ST TSV-13 as the most prevalent (n = 7), and were less likely to possess an LPS A genotype or YLF gene cluster (p < 0.001). These isolates were most likely to be found outside the inner city (aOR: 4.0, 95% CI: 1.7–9.0, p = 0.001). ST TSV-13 was associated with increased mortality (aOR: 6.1, 95% CI: 1.2–30.9, p = 0.03). Patients with a history of alcohol excess were less likely to be infected by fhaB3 (aOR 0.2, 95% CI: 0.1–0.7, p = 0.01) or YLF (aOR: 0.4, 95% CI: 0.2–0.9, p = 0.04) positive isolates. Conclusions: There are a significant number of novel sequence types in Townsville, Australia. An emerging novel ST appears to have an association with geographic location and mortality. Ongoing investigation is required to further understand the impact of this ST on the Townsville region.
Pengembangan Asesmen Autentik dengan Pendekatan Saintifik pada Pembelajaran Tematik untuk Mengukur Dimensi Bernalar Kritis Siswa Kelas V Sekolah Dasar
Authors: Reni Ekawati Sulistyo  , Sumarno  , Purnamasari Iin 
Published: July 2024

Tujuan dari penelitian ini adalah 1) mendeskripsikan kevalidan ; 2) menganalisis kepraktisan ; 3) menguji keefektifan asesmen autentik dengan pendekatan Saintifik pada pembelajaran tematik untuk mengukur dimensi bernalar kritis siswa kelas V Sekolah Dasar. Penelitian ini merupakan penelitian pengembangan dengan menggunakan pendekatan yang dikembangkan oleh Borg dan Gall, yang terdiri dari (1) tahap potensi dan masalah; (2) pengumpulan data; (3) desain produk; (4) validasi desain; (5) revisi desain; (6) uji coba produk; (7) revisi produk; dan (8) uji coba pemakaian.Data penelitian adalah sebagai berikut: 1) uji validitas diperoleh rata-rata 0,849 dengan kriteria sangat baik; 2) uji kepraktisan diperoleh skor persentase sebesar 73,42 dengan kategori sangat baik; 3) uji keefektivan diperoleh dari validitas butir soal, reliabilitas, tingkat kesukaran, daya pembeda, dan sensitivitas butir soal. Uji validitas butir soal pada aspek sikap menunjukkan bahwa rubrik penilaian sikap, soal pengetahuan, dan rubrik penilaian keterampilan diperoleh rhitung>rtabel sehingga dinyatakan valid dan nilai alpha >0,60 sehingga dinyatakan reliabel. Tingkat kesukaran pada kriteria sedang, daya pembeda soal pada kategori cukup dan baik, dan sensitivitas butir soal berniai positif.Simpulan penelitian ini adalah bahwa asesmen autentik dengan pendekatan saintifik pada pembelajaran tematik dinyatakan valid, praktis, dan efektif.