bluuebunny/crossref_metadata_2025_split huggingface dataset:
Survey of Transplant-Related Pharmacy Services at Large Comprehensive Transplant Centers in the United States
Authors: Staino Carmelina , Lewin John J. , Nesbit Todd W. , Sullivan Brigitte , Ensor Christopher R. 
Published: March 2013

Context United Network for Organ Sharing (UNOS) 2011 bylaws and Centers for Medicare and Medicaid Services (CMS) regulations require a transplant pharmacist to be an active participant in the care of transplant patients. Transplant centers must be members in good standing with UNOS in order to perform transplants and must be certified by CMS to participate with Medicare. Objective To identify characteristics of transplant-related pharmacy services at comprehensive transplant centers. Design Survey regarding number of full-time equivalent (FTE) transplant pharmacists relative to number of annual transplants, transplant pharmacy model, roles in inpatient and clinic environments, training and specialization, funding sources, and expansion plans. Participants Surveys were received from 14 (74%) of 19 identified centers that performed 200 to 400 kidney, liver, pancreas, simultaneous kidney/pancreas, heart, and lung transplants in 2010, representing 55 transplant pharmacists. Results—A mean of 325 transplants were performed in 2010 at the surveyed centers. The mean number of pharmacist FTEs was 4.25, which yielded a transplant-to-pharmacist ratio of 76.5. Nine centers (64%) practiced in a pharmacy specialist-only model, 12 (86%) practiced in a service-based fashion, and 10 (71%) saw patients in clinic. Fifty-four pharmacists (98%) had obtained a PharmD degree, 45 (82%) had completed 1 postgraduate year, and 28 (51%) had completed 2 postgraduate years of training. Nine centers (64%) funded FTEs solely through the pharmacy department. Ten centers (71%) plan to expand transplant pharmacist staff by a mean of 1.4 FTEs. Conclusions Large comprehensive transplant centers use multiple transplant pharmacists to perform patient care in the inpatient and outpatient environments. Most centers plan to expand FTEs. Further characterization of transplant pharmacists appears warranted.
Multi Variant Surface Mounted Metal–Organic Frameworks
Authors: Liu Bo , Tu Min , Zacher Denise , Fischer Roland A. 
Published: March 2013

AbstractHybrid surface mounted metal–organic frameworks (h‐SURMOFs) of multi variant core‐shell (cs) and core–shell–shell (css) structures (SURMOF A‐B and A‐B‐C, A: [Cu2(bdc)2(dabco)]; B: [Cu2(NH2‐bdc)2(dabco)]; C: [Cu2(ndc)2(dabco)], bdc = 1,4‐benzenedicarboxylate; NH2‐bdc = 2‐amino‐1,4‐benzenedicarboxylate; ndc = 1,4‐naphtalenedicarboxylate; dabco = 1,4‐diazabicyclo[2.2.2]octane) with specific crystallographic [001] orientation and incorporated amino groups at a controllable depth within the bulk are deposited via liquid phase epitaxial (LPE) approach on pyridyl‐terminated self‐assembled monolayers (SAM). The location of the (amino) functionality can be precisely controlled through tuning the thickness (number of deposition cycles) of each sub‐multilayer block according to the LPE deposition protocol. The chemo‐selective and location‐specific post deposition (chemical) modification of the amino groups in the cs and css‐type h‐SURMOF samples is achieved. The h‐SURMOFs allow one to probe functional groups at certain location in the volume of hybrid MOF crystallites attached to surfaces as thin film coatings. Multiplex adsorption kinetics of FPI (FPI = 4‐fluorophenyl isothiocyanate) is observed in h‐SURMOFs due to their multi‐variant pore structures in samples of A‐B and A‐B‐C. Conceptually, the stepwise LPE growth method enables fabrication of hybrid SURMOFs and incorporation of multi‐variant functionalities into one homogeneous thin film material, providing precisely tunable pore environment for selective adsorption, separation, etc.
Racemization‐Free Chemoenzymatic Peptide Synthesis Enabled by the Ruthenium‐Catalyzed Synthesis of Peptide Enol Esters via Alkyne‐Addition and Subsequent Conversion Using Alcalase‐Cross‐Linked Enzyme Aggregates
Authors: Schröder Hilmar , Strohmeier Gernot A. , Leypold Mario , Nuijens Timo , Quaedflieg Peter J. L. M. , Breinbauer Rolf 
Published: March 2013

AbstractThe C‐terminal activation of peptides as prerequisite for the formation or ligation of peptide fragments is often associated with the problem of epimerization. We report that ruthenium‐catalyzed alkyne addition with (+)‐2,3‐O‐isopropylidene‐2,3‐dihydroxy‐1,4‐bis(diphenylphosphino)butane as ligand allows the racemization‐free synthesis of peptide enol esters tolerating a wide range of functional groups. The transformation can be performed in a variety of different solvents addressing the solubility issues imposed by peptides with varying amino acid side chain patterns. We show that peptide enol esters with an amide motif in the enol moiety are excellent acyl donors for the peptide condensation with other peptide fragments in organic solvents using serine endopeptidase subtilisin A as catalyst. The reported combination of transition metal catalysis with enzymatic peptide ligations adds an important tool for the racemization‐free synthesis and ligation of peptides which is compatible even with unprotected amino acid side chains.
An Asymmetric Organocatalytic Quadruple Cascade Initiated by a Friedel–Crafts‐Type Reaction with Electron‐Rich Arenes
Authors: Erdmann Nico , Philipps Arne R. , Atodiresei Iuliana , Enders Dieter 
Published: March 2013

AbstractAn organocatalytic quadruple domino reaction initiated by a Friedel–Crafts‐type reaction of electron‐rich arenes is described. The procedure involving up to three different Michael acceptors afforded highly functionalized cyclohexenecarbaldehydes bearing an aniline moiety, which are of great pharmaceutical and agricultural interest. This diphenylprolinol trimethylsilyl ether‐catalyzed reaction also generates up to 4 contiguous stereocenters. It could be shown that various functional groups are tolerated and all products were obtained with very good diastereo‐ and excellent enantioselectivity.
Precarious employment, psychosocial working conditions, and health: Cross‐sectional associations in a population‐based sample of working Australians
Authors: Keuskamp Dominic , Ziersch Anna M. , Baum Fran E. , LaMontagne Anthony D. 
Published: March 2013

AbstractBackgroundPrecarious employment has been associated with poor health, but the potential mechanisms are unclear. We examined the relationships between precarious employment and health, and investigated psychosocial working conditions as potential mediators.MethodsA cross‐sectional population‐based survey was conducted in South Australia in 2009 (N = 1,016 employed). SF‐12 measures of mental and physical health were modeled using logistic regression in relation to employment arrangement, controlling for socio‐demographics, years in job and psychosocial working conditions.ResultsThere was no association between casual full‐time or part‐time employment and poor mental health in multivariate analyses. Conversely, there was a significant association between casual full‐time employment and poor physical health (compared to permanent full‐time workers, OR = 3.14, 95% CI 1.26–7.85). The association with physical health was unaffected by adjustment for psychosocial working conditions.ConclusionsCasual full‐time employment was strongly associated with poor physical health but not with poor mental health. This association was not mediated by the psychosocial working conditions measured in this study, but may be related to other (unmeasured) working conditions. Am. J. Ind. Med. 56:838–844, 2013. © 2013 Wiley Periodicals, Inc.
A quantitative approach for understanding small‐scale human mesenchymal stem cell culture – implications for large‐scale bioprocess development
Authors: Rafiq Qasim A. , Coopman Karen , Nienow Alvin W. , Hewitt Christopher J. 
Published: March 2013

AbstractHuman mesenchymal stem cell (hMSC) therapies have the potential to revolutionise the healthcare industry and replicate the success of the therapeutic protein industry; however, for this to be achieved there is a need to apply key bioprocessing engineering principles and adopt a quantitative approach for large‐scale reproducible hMSC bioprocess development. Here we provide a quantitative analysis of the changes in concentration of glucose, lactate and ammonium with time during hMSC monolayer culture over 4 passages, under 100% and 20% dissolved oxgen (dO2), where either a 100%, 50% or 0% growth medium exchange was performed after 72h in culture. Yield coefficients, specific growth rates (h‐1) and doubling times (h) were calculated for all cases. The 100% dO2 flasks outperformed the 20% dO2 flasks with respect to cumulative cell number, with the latter consuming more glucose and producing more lactate and ammonium. Furthermore, the 100% and 50% medium exchange conditions resulted in similar cumulative cell numbers, whilst the 0% conditions were significantly lower. Cell immunophenotype and multipotency were not affected by the experimental culture conditions. This study demonstrates the importance of determining optimal culture conditions for hMSC expansion and highlights a potential cost savings from only making a 50% medium exchange, which may prove significant for large‐scale bioprocessing.
Cooperative binding of 2,2′‐bipyridine into polynucleotide poly(A)–poly(U‐) in an alkaline aqueous solution
Authors: Kudrev Andrei G. 
Published: March 2013

ABSTRACTUV absorption data analysis has been used to evaluate equilibrium constants of the pH‐induced interaction of 2,2′‐Bipy with polyadenylnic‐polyuridylic acid in aqueous solution. The conditional probabilities hard model has been adopted in treatment of concentration diagrams calculated by the soft modelling‐based Multivariate Curve Resolution‐Alternating Least Squares approach. Intrinsic binding constant (lgKg = 1.93), and the cooperativity parameter (ω = 340), were calculated as the best fit. The plot of the experimental binding constant versus 2,2′‐Bipy equilibrium concentration shows two modes of ligand with polymer interactions. The equilibrium hard model correctly reproduced the binding constant variations observed in the experiment. The results indicated that ligand binding in two steps is governed by a cooperative process, that is, the enhancement of deprotonated structure stability. It would appear that proposed calculation approach can be used in future combined hard modelling theoretical and soft modelling experimental works. © 2013 Wiley Periodicals, Inc. Biopolymers 99:621–627, 2013.
Reactions of Copper(II) Chloride in Solution: Facile Formation of Tetranuclear Copper Clusters and Other Complexes That Are Relevant in Catalytic Redox Processes
Authors: Löw Sabine , Becker Jonathan , Würtele Christian , Miska Andreas , Kleeberg Christian , Behrens Ulrich , Walter Olaf , Schindler Siegfried 
Published: March 2013

AbstractMixing CuCl2⋅2 H2O with benzylamine in alcoholic solutions led to an extremely colorful chemistry caused by the formation of a large number of different complexes. Many of these different species could be structurally characterized. These include relatively simple compounds such as [Cu(L1)4Cl2] (L1=benzylamine) and (HL1)2[CuCl4]. Most interestingly is the easy formation of two cluster complexes, one based on two cluster units Cu4OCl6(L1)4 connected through one [Cu(L1)2Cl2] complex and one based on a cubane‐type cluster ([Cu4O4](C11H14)4Cl4). Both clusters proved to be highly reactive in a series of oxidation reactions of organic substrates by using air or peroxides as oxidants. Furthermore, it was possible to isolate and structurally characterize ([Cu(L1)Cl]3 and [Cu(benz2mpa)2]CuCl2 (benz2mpa=benzyl‐(2‐benzylimino‐1‐methyl‐propylidene)‐amine), two copper(I) complexes that formed in solution, demonstrating the high redox activity of the cluster systems. In addition, it was possible to solve the molecular structures of the compounds Cu4OCl6(MeOH)4, [Cu(MeOH)2Cl2], [Cu(aniline)2Cl2], and an organic side product (HC13H19NOCl). In fact all determined structures are of a known type but the chemical relation between these compounds could be explained for the first time. The paper describes these different compounds and their chemical equilibria. Some of these complexes seem to be relevant in catalytic oxidation reactions and their reactivity is discussed in more detail.
Noncovalent Tagging Proteins with Paramagnetic Lanthanide Complexes for Protein Study
Authors: Wei Zhen , Yang Yin , Li Qing‐Feng , Huang Feng , Zuo Hui‐Hui , Su Xun‐Cheng 
Published: March 2013

AbstractThe site‐specific labeling of proteins with paramagnetic lanthanides offers unique opportunities for NMR spectroscopic analysis in structural biology. Herein, we report an interesting way of obtaining paramagnetic structural restraints by employing noncovalent interaction between a lanthanide metal complex, [Ln(L)3]n− (L=derivative of dipicolinic acid, DPA), and a protein. These complexes formed by lanthanides and DPA derivatives, which have different substitution patterns on the DPA derivatives, produce diverse thermodynamic and paramagnetic properties when interacting with proteins. The binding affinity of [Ln(L)3]n− with proteins, as well as the determined paramagnetic tensor, are tunable by changing the substituents on the ligands. These noncovalent interactions between [Ln(L)3]n− and proteins offer great opportunities in the tagging of proteins with paramagnetic lanthanides. We expect that this method will be useful for obtaining multiple angles and distance restraints of proteins in structural biology.
ChemInform Abstract: Temperature‐Dependent Structural Studies of Mullite‐Type Bi2Fe4O9.
Authors: Murshed M. Mangir , Nenert Gwilherm , Burianek Manfred , Robben Lars , Muehlberg Manfred , Schneider Hartmut , Fischer Reinhard X. , Gesing Thorsten M. 
Published: March 2013

AbstractThe thermal expansion of the title compound (space group Pbam) is investigated by single crystal neutron diffraction at 298 and 900 K and powder XRD over the range 298—1173 K.
ChemInform Abstract: The New Barium Mercuride BaHg6 and Ternary Indium and Gallium Derivatives.
Authors: Wendorff Marco , Roehr Caroline 
Published: March 2013

AbstractBaHg6 (I), BaIn1.2Hg4.8 (II), and BaGa0.8Hg5.2 (III) are obtained from melts of the elements in Ta crucibles by slow cooling from 500 to 200 °C.
ChemInform Abstract: Amine Templating Effect Absent in Uranyl Sulfates Synthesized with 1,4‐n‐Butyldiamine.
Authors: Jouffret Laurent J. , Wylie Ernest M. , Burns Peter C. 
Published: March 2013

AbstractThe new compounds (IV) and (V) crystallize in the monoclinic space group P21/n with Z = 4 (single crystal XRD).
ChemInform Abstract: Synthesis, Crystal Structure, and Properties of KSbO3‐Type Bi3Mn1.9Te1.1O11.
Authors: Greenblatt Martha , et al. et al. 
Published: March 2013

AbstractSingle crystals of the title compound are prepared by reaction of a stoichiometric mixture of Bi2O3, MnCO3, and TeO2 in a NaCl/KCl flux (air, open quartz tube, 750 °C, 10 d).
ChemInform Abstract: New Multifunctional Chiral Phosphines and BINOL Derivatives Co‐Catalyzed Enantioselective Aza‐Morita—Baylis—Hillman Reaction of 5,5‐Disubstituted Cyclopent‐2‐enone and N‐Sulfonated Imines.
Authors: Yang Yuan‐Liang , Wei Yin , Shi Min 
Published: March 2013

AbstractA chiral and strong nucleophilic phosphine amide catalyst combined with a BINOL derivative catalyzes the asymmetric aza‐Morita—Baylis—Hillmann reaction of disubstituted cyclopentenones (I) and (IV) with N‐sulfonated imines (II) and (V) to provide the optically active adducts (III) and (VI) in good to outstanding yields with moderate to good enantioselectivities.
ChemInform Abstract: Camphor‐Derived C1‐Symmetric Chiral Diamine Organocatalysts for Asymmetric Michael Addition of Nitroalkanes to Enones.
Authors: Zhou Yirong , Liu Qiang , Gong Yuefa 
Published: March 2013

AbstractA small library of novel C1‐symmetric chiral diamines is constructed in moderate to good yields by using three protocols.
ChemInform Abstract: Halofluorination of Alkenes Mediated by 1,1,3,3,3‐Pentafluoropropene‐diethylamine Adduct.
Authors: Walkowiak Justyna , Marciniak Bartosz , Koroniak Henryk 
Published: March 2013

AbstractThe halofluorination reaction most probably proceeds via controlled generation of limited amounts of hydrogen fluoride from the 1,1,3,3,3‐pentafluoropropene‐diethylamine adduct PFPD.
ChemInform Abstract: Ligated Regioselective PdII Catalysis to Access β‐Aryl‐Bearing Aldehydes, Ketones, and β‐Keto Esters.
Authors: Vellakkaran Mari , Andappan Murugaiah M. S. , Kommu Nagaiah 
Published: March 2013

AbstractThe title acid‐free method is based on the coupling of allyl alcohols with arylboronic acids to access dihydrochalcones, dihydrocinnamaldehydes, and β‐arylketones with more tolerance of functionalities than previously reported.
ChemInform Abstract: Palladium(II)‐Catalyzed Regioselective ortho Arylation of sp2 C—H Bonds of N‐Aryl‐2‐amino Pyridine Derivatives.
Authors: Koley Moumita , Dastbaravardeh Navid , Schnuerch Michael , Mihovilovic Marko D. 
Published: March 2013

AbstractThe convenient method uses pyridine as directing group.
ChemInform Abstract: Straightforward Synthesis of Aromatic Imines from Alcohols and Amines or Nitroarenes Using an Impregnated Copper Catalyst.
Authors: Perez Juana M. , Cano Rafael , Yus Miguel , Ramon Diego J. 
Published: March 2013

AbstractThe present magnetically removable catalyst system consisting of impregnated copper on magnetite is used for the synthesis of imines starting from alcohols and aryl amines or nitroarenes.
ChemInform Abstract: A Facile and Efficient Synthesis of 2,2,2‐Trifluoroethyl 2‐[(E)‐N‐Phenylcinnamamido]‐2‐phenylacetates in Trifluoroethanol via Sequential Ugi Four‐Component Reaction/Esterification.
Authors: Balalaie Saeed , Motaghedi Hassan , Tahmassebi Daryoush , Bararjanian Morteza , Bijanzadeh Hamid Reza 
Published: March 2013

AbstractThe primary Ugi adducts (V) are esterified by the solvent (VI) under conditions B) to afford the highly functionalized scaffolds of type (VII).
ChemInform Abstract: Synthesis of α‐Aminonitriles Using Silica‐Bonded N‐Propylpiperazine Sulfamic Acid as a Recyclable Catalyst.
Authors: Rahi Tahere , Baghernejad Mojtaba , Niknam Khodabakhsh 
Published: March 2013

AbstractA simple protocol for the three‐component condensation of aldehydes, amines, and trimethylsilyl cyanide to yield α‐aminonitriles (IV) (12 examples) is developed using a heterogeneous supported sulfamic acid as the catalyst.
ChemInform Abstract: AgI‐Catalyzed Cascade Strategy: Regioselective Access to Diversely Substituted Fused Benzimidazo[2,1‐a]isoquinolines, Naphthyridines, Thienopyridines and Quinoxalines in Water.
Authors: Rustagi Vineeta , Tiwari Rakesh , Verma Akhilesh Kumar 
Published: March 2013

AbstractTitle compounds are synthesized in one step by the present eco‐friendly reaction of o‐alkynyl aldehydes and amines in water using AgNO3 as catalyst.
ChemInform Abstract: Phosphine‐Catalyzed Domino Reaction: An Efficient Method for the Synthesis of Highly Functionalized Spirooxazolines.
Authors: Yang Lihua , Xie Peizhong , Li Erqing , Li Xin , Huang You , Chen Ruyu 
Published: March 2013

AbstractA new class of spirocyclic oxindole derivatives is obtained in good to high yields and stereoselectivity by a novel phosphine‐catalyzed intermolecular [3 + 2]cycloaddition of isatins and ynones.
ChemInform Abstract: A Diversity‐Oriented Approach to Spiroindolines: Post‐Ugi Gold‐Catalyzed Diastereoselective Domino Cyclization.
Authors: Modha Sachin G. , Kumar Amit , Vachhani Dipak D. , Jacobs Jeroen , Sharma Sunil K. , Parmar Virinder S. , Van Meervelt Luc , Van der Eycken Erik V. 
Published: March 2013

AbstractA mild and efficient synthesis of the title compounds is developed from readily available starting materials.
ChemInform Abstract: Construction of Naphtho‐Fused Oxindoles via the Aryne Diels—Alder Reaction with Methyleneindolinones.
Authors: Li Jian , Wang Ning , Li Chunju , Jia Xueshun 
Published: March 2013

AbstractThe process renders possible the access to a broad spectrum of highly functionalized N‐heterocyclic systems incorporating the indole scaffold.
ChemInform Abstract: A Novel Synthesis of Thioglycolurils by Ring Contraction of 5,7‐Dialkyl‐3‐thioxoperhydroimidazo[4,5‐e]‐1,2,4‐triazin‐6‐ones.
Authors: Gazieva Galina A. , Poluboyarov Pavel A. , Popov Leonid D. , Kolotyrkina Natalya G. , Kravchenko Angelina N. , Makhova Nina N. 
Published: March 2013

AbstractTriazinethiones of type (I) are found to undergo a novel type of ring contraction by acid catalyzed reaction with aromatic aldehydes to give thioglycolurils (III) in moderate yields.
ChemInform Abstract: Synthesis of Oxazolidinones, Dioxazolidinone and Polyoxazolidinone (a New Polyurethane) via a Multi Component‐Coupling of Aldehyde, Diamine Dihydrochloride, Terminal Alkyne and CO2.
Authors: Teffahi Djamila , Hocine Smain , Li Chao‐Jun 
Published: March 2013

AbstractOptimized conditions A) render possible the preparation of various oxazolidinone structures.
ChemInform Abstract: Palladium‐Catalyzed, Pyrrolidine‐Mediated Arylmethylation of Ketones and Aldehydes with Coumarinyl(methyl) Acetates.
Authors: Cattopadhyay Kalicharan , Recio Antonio III , Tunge Jon A. 
Published: March 2013

AbstractThe mild α‐benzylation of enamines generated from aldehydes and ketones is reported.
ChemInform Abstract: Mild Metal‐Free Tandem α‐Alkylation/Cyclization of N‐Benzyl Carbamates with Simple Olefins.
Authors: Richter Heinrich , Froehlich Roland , Daniliuc Constantin‐Gabriel , Garcia Mancheno Olga 
Published: March 2013

AbstractThe first examples for metal‐free α‐alkylation of N‐benzyl carbamates are presented.
ChemInform Abstract: Kinetic versus Thermodynamic Stereoselectivity in the Hydrostannylation of Propargylic Alcohol Derivatives Using AIBN and Et3B as Promotors.
Authors: Oderinde Martins S. , Hunter Howard N. , Organ Michael G. 
Published: March 2013

AbstractWhile BEt3/air furnishes the kinetically controlled Z‐isomer in the title reaction, isomerization is observed in the analog AIBN‐mediated reactions.
ChemInform Abstract: Lignans and Triterpenes from the Root of Pseuderanthemum carruthersii var. atropurpureum.
Authors: Vo Thi Nga , Nguyen Phi Linh , Tuong Lam Truong , Pratt Lawrence Michael , Vo Phung Nguyen , Nguyen Kim Phi Phung , Nguyen Ngoc Suong 
Published: March 2013

AbstractTwo new lignans, pseuderesinol (I) and pseuderanoside (II), and a new triterpene, pseuderanic acid (III), are isolated together with ten known compounds.
Study of the Transient Reactive Pd(IV) Intermediate in the Pd(OAc)2‐Catalyzed Oxidative Coupling Reaction System by Electrospray Ionization Tandem Mass Spectrometry
Authors: Zhu Wei , Wang Haoyang , Peng Haihui , Liu Guosheng , Guo Yinlong 
Published: March 2013

AbstractPd‐catalyzed oxidative coupling reaction was of great importance in the aromatic CH activation and the formation of new CO and CC bonds. Sanford has pioneered practical, directed CH activation reactions employing Pd(OAc)2 as catalyst since 2004. However, until now, the speculated reactive Pd(IV) transient intermediates in these reactions have not been isolated or directly detected from reaction solution. Electrospray ionization tandem mass spectrometry (ESI‐MS/MS) was used to intercept and characterize the reactive Pd(IV) transient intermediates in the solutions of Pd(OAc)2‐catalyzed oxidative coupling reactions. In this study, the Pd(IV) transient intermediates were detected from the solution of Pd(OAc)2‐catalyzed oxidative coupling reactions by ESI‐MS and the MS/MS of the intercepted Pd(IV) transient intermediate in reaction system was the same with the synthesized authentic Pd(IV) complex. Our ESI‐MS(/MS) studies confirmed the presence of Pd(IV) reaction transient intermediates. Most interestingly, the MS/MS of Pd(IV) transient intermediates showed the reductive elimination reactivity to Pd(II) complexes with new CO bond formation into product in gas phase, which was consistent with the proposed reactivity of the Pd(IV) transient intermediates in solution.