bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Utah Beacon Experience: Integrating Quality Improvement, Health Information
Technology, and Practice Facilitation to Improve Diabetes Outcomes in Small Healthcare
Facilities
Authors: Tennison Janet , Rajeev Deepthi , Woolsey Sarah , Black Jeff , Oostema Steven J. , North Christie 
Published: August 2014

Purpose: The Utah Improving Care through Connectivity and Collaboration (IC3)
Beacon community (2010–2013) was spearheaded by HealthInsight, a nonprofit,
community-based organization. One of the main objectives of IC3 was to improve health
care provided to patients with diabetes in three Utah counties, collaborating with 21
independent smaller clinics and two large health care enterprises. This paper will focus
on the use of health information technology (HIT) and practice facilitation to develop
and implement new care processes to improve clinic workflow and ultimately improve
patients’ diabetes outcomes at 21 participating smaller, independent clinics.Innovation:
Early in the project, we learned that most of the 21 clinics did not have the resources
needed to successfully implement quality improvement (QI) initiatives. IC3helped clinics
effectively use data generated from their electronic health records (EHRs) to design and
implement interventions to improve patients’ diabetes outcomes. This close coupling of
HIT, expert practice facilitation, and Learning Collaboratives was found to be
especially valuable in clinics with limited resources.Findings: Through this process we
learned that (1) an extensive readiness assessment improved clinic retention, (2) clinic
champions were important for a successful collaboration, and (3) current EHR systems
have limited functionality to assist in QI initiatives. In general, smaller, independent
clinics lack knowledge and experience with QI and have limited HIT experience to improve
patient care using electronic clinical data. Additionally, future projects like
IC3 Beacon will be instrumental in changing clinic culture so that QI is integrated into
routine workflow.Conclusion and Discussion: Our efforts led to significant changes in
how practice staff optimized their EHRs to manage and improve diabetes care, while
establishing the framework for sustainability. Some of the IC3 Beacon practices are
currently smoothly transitioning to new models of care such as Patient-Centered Medical
Homes. Thus, IC3 Beacon has been instrumental in creating a strong community partnership
among various organizations to meet the shared vision of better health and lower costs,
and the experience over the last few years has helped the community prepare for the
changing health care landscape.
Tacrolimus Pharmacodynamics and Pharmacogenetics along the Calcineurin Pathway in Human Lymphocytes
Authors: Noceti Ofelia M , Woillard Jean-Baptiste , Boumediene Ahmed , Esperón Patricia , Taupin Jean-Luc , Gerona Solange , Valverde Marcelo , Touriño Cristina , Marquet Pierre 
Published: August 2014

AbstractBACKGROUNDAlthough therapeutic drug monitoring has improved the clinical use of immunosuppressive drugs, there is still interpatient variability in efficacy and toxicity that pharmacodynamic monitoring may help to reduce. To select the best biomarkers of tacrolimus pharmacodynamics, we explored the strength and variability of signal transduction and the influence of polymorphisms along the calcineurin pathway.METHODSPeripheral blood mononuclear cells from 35 healthy volunteers were incubated with tacrolimus (0.1–50 ng/mL) and stimulated ex vivo. Inhibition of NFAT1 (nuclear factor of activated T cells 1) translocation to the nucleus and intracellular expression of interleukin-2 in CD4+ and CD8+ T cells and the surface activation marker CD25 in CD3+ cells were measured by flow cytometry. We sequenced the promoter regions of immunophilins and calcineurin subunits and characterized selected single nucleotide polymorphisms in the genes of the calcineurin pathway with allelic discrimination assays.RESULTSAll responses closely fitted an I/Imax sigmoid model. Large interindividual variability (n = 30) in I0 and IC50 was found for all biomarkers. Moreover, strong and statistically significant associations were found between tacrolimus pharmacodynamic parameters and polymorphisms in the genes coding cyclophilin A, the calcineurin catalytic subunit α isoenzyme, and CD25.CONCLUSIONSThis study demonstrates the consistency and large interindividual variability of signal transduction along the calcineurin pathway, as well as the strong influence of pharmacogenetic polymorphisms in the calcineurin cascade on both the physiological activity of this route and tacrolimus pharmacodynamics.
Cooperative actions of p21WAF1 and p53 induce Slug protein degradation and suppress cell invasion
Authors: Kim Jongdoo , Bae Seunghee , An Sungkwan , Park Jong Kuk , Kim Eun Mi , Hwang Sang‐Gu , Kim Wun‐Jae , Um Hong‐Duck 
Published: August 2014

AbstractHow the p53 transcription factor/tumor suppressor inhibits cell invasion is poorly understood. We demonstrate that this function of p53 requires its direct interaction with p21WAF1, a transcriptional target of p53, and that both p21 and p53 bind to Slug, which promotes cell invasion. Functional studies reveal that p21 and p53 cooperate to facilitate Mdm2‐dependent Slug degradation and that this p53 function is mimicked by p53R273H, a mutant lacking trans‐activating activity. These actions of p21 and p53 are induced by γ‐irradiation of cells and also operate in vivo. This is the first study to elucidate a mechanism involving p53 and p21 cooperation.
Geophysical Characterization of the Keene Valley Landslide in New York State
Authors: Sherrod Laura , Schlosser Kenneth , Kozlowski Andrew , Bird Brian , Werkema D. Dale , Swiontek Jarred 
Published: August 2014

The largest naturally occurring landslide in New York State history began in early May 2011. Melting of winter snowpack followed by abnormally high volumes of April rain saturated the underlying glacial stratigraphy and initiated the 0.33 km2(82 acre) landslide on Little Porter Mountain in the High-Peaks region of the Adirondack Mountains. Downslope soil movement rates between 15 and 60 cm per day demonstrated their destructive capacity as the shifting soils caused one house to be condemned because of the unstable ground and foundation while simultaneously rendering three other houses into immediate danger. The mechanisms controlling this landslide were investigated using geophysical methods, displacement measurements, and borehole logs. Nineteen electrical resistivity imaging surveys were implemented to map the subsurface glacial features. Ground penetration radar (GPR) profiles were collected along many of the resistivity lines and additional reconnaissance lines in several other locations. These surveys identified subsurface features such as the buried bedrock surface, thick sequences of loose zones of saturated sediments and clays within the glacial till, and boulder zones. The geophysical data were compared with displacement station measurements and precipitation records, which led to the interpretation that the landslide was triggered by large infiltration and the failure surface was along a clay-sand interface. The nature of the slide is revealed as a deep-seated rotational surface within the glacial deposits instead of the bedrock debris avalanche failures that are considered typical of the Adirondack region. The results of this study assist in the Little Porter Mountain landslide characterization and hazard potential classification of similar glacial deposits on slopes in the Adirondacks region.
Profiling USGA Putting Greens Using GPR—An As-built Surveying Method
Authors: Freeland Robert S , Allred Barry J , Sorochan John C 
Published: August 2014

Putting greens that are constructed to United State Golf Association (USGA) standards must adhere to strict installation specifications to maintain proper subsurface drainage. Because the infrastructure is buried, it can be difficult to ascertain if these structures were properly installed. Insufficient drainage affects agronomics, compromising the playability of the putting surface. Repairs are expensive and laborious. This study introduces a nonintrusive survey protocol that combines ground-penetrating radar (GPR) and real-time kinematic (RTK) positioning. A case study was used to examine a putting green designed using the USGA specifications. The protocol created “as-built” subsurface maps. The protocol non-intrusively identified the tile slope and spacing. It also determined the depth and thickness of the root-zone mixture and gravel. The green adhered to the tile spacing specification, but failed to meet specifications as to tile slope and root-zone mixture depth. These findings suggest that this protocol provides a relatively inexpensive method to determine adherence to USGA greens standards. Generated maps highlighted conformity (or lack thereof) to the design specifications.
Pressure-Transient Analysis of Multiwing Fractures Connected to a Vertical Wellbore
Authors: Wanjing Luo , Changfu Tang 
Published: August 2014

Summary
The principal focus of this work is on transient-pressure behaviors of multiwing fractures connected to a vertical wellbore. The vertical well is fractured with multiple-fracture wings with varied intersection angle, length, and asymmetry factor (AF). In the case of equally spaced fractures connected to a vertical wellbore, three flow regimes may be observed: bilinear-flow regime, formation linear flow, and pseudoradial-flow regime. With the increase of fracture numbers, the interaction of fractures becomes stronger and a “hump” occurs on the curves of pressure derivative for low and moderate fracture conductivities. For an anisotropic formation, the fracture may grow at a specific azimuth, and a fracture cluster develops. Because of the strong interactions among fracture clusters, the end of bilinear flow occurs earlier, and the formation linear flow will not be observed even for high fracture conductivities. In some extreme case in which a vertical well is intercepted with highly asymmetrically distributed fracture clusters, its transient performances of pressure and pressure-derivative curves may deviate from the conventional type curves totally. In addition, it is found that the complexity of multiple fractures near the wellbore can enhance the recovery of oil and gas.
Satellite-derived volume loss rates and glacier speeds for the Juneau Icefield, Alaska
Authors: Melkonian Andrew K. , Willis Michael J. , Pritchard Matthew E. 
Published: August 2014

AbstractWe provide a high-resolution map of elevation change rates at the Juneau Icefield (JIF), southeastern Alaska, in order to quantify its contribution to sea-level rise between 2000 and 2009/2013. We also produce the first high-resolution map of ice speeds at the JIF, which we use to constrain flux and look for acceleration. We calculate using stacked digital elevation models (DEMs) from the Advanced Spaceborne Thermal Emission and Reflection Radiometer (ASTER) instrument and the Shuttle Radar Topography Mission (SRTM), taking into account SRTM C-band penetration via comparison with SRTM X-band elevations. Overall, the JIF is losing mass less rapidly (0.13 ± 0.12 m w.e. a–1) than other Alaskan icefields (0.79 m w.e. a–1). We determine glacier speeds using pixel-tracking on optical image pairs acquired from 2001 to 2010 by ASTER, from radar image pairs acquired between 2007 and 2011 and from radar interferometry in 1995. We detect seasonal speed variations but no interannual acceleration, ruling out dynamics as the cause of the observed thinning. Thinning must therefore be due to the documented warming in the region. Flux measurements confirm this for Mendenhall Glacier, showing that calving constitutes only 2.5–5% of mass loss there.
Experimental determination of the absorption enhancement parameter of snow
Authors: Libois Quentin , Picard Ghislain , Dumont Marie , Arnaud Laurent , Sergent Claude , Pougatch Evelyne , Sudul Marcel , Vial David 
Published: August 2014

AbstractIn optical models snow is commonly treated as a disperse collection of particles. In this representation, the penetration depth of solar radiation is sensitive to the shape of the particles, in particular to the absorption enhancement parameter, B, that quantifies the lengthening of the photon path inside grains due to internal multiple reflections. Spherical grains, with theoretical B = 1.25, are often used. We propose an experimental method to determine B, and apply it to 36 snow samples and 56 snow strata. The method is based on radiative transfer modeling and combined measurements of reflectance and irradiance profiles. Such measurements are performed in the laboratory and in the field, in Antarctica and the French Alps. The retrieved values of B are in the range 0.7–2.4, with a wide peak between 1.4 and 1.8. An analysis of measurement error propagation based on a Bayesian framework shows that the uncertainty on B is ± 0.1, which is the order of magnitude of variations between different snow types. Thus, no systematic link between B and snow type can be inferred. Here we recommend using shapes with B = 1.6 to model snow optical properties, rather than spherical grains.
La maison urbaine et son évolution dans la ville basse de Viviers (Ardèche), XIIe-XVe siècles
Authors: Grasse Marie-Christine 
Published: August 2014

La maison urbaine et son évolution dans la ville basse de Viviers (Ardèche), XIIe-XVe siècles.
Dans la mesure où la ville évolue constamment, où elle est perpétuellement transformée par des constructions, des travaux, etc., un intérêt particulier doit être porté à la maison, témoin d'une société passée.
En essayant de présenter le paysage urbain de Viviers à la fin du Moyen Age on se heurte aux difficultés liées à la rareté et à la restriction des sources écrites et des vestiges architecturaux encore visibles. Il existe peu de travaux traitant de l'architecture civile provençale. Fréquemment, ils relatent plus l'évolution de l'urbanisme que celle de la maison elle- même.
L'évolution de l'habitat ne peut être envisagée sans l'élaboration d'une chronologie, relative, des types d'appareils et d'ouvertures permettant ainsi une reconstitution de l'organisation de la façade. Celle-ci annonce l'agencement intérieur des bâtiments, au moins pour les pièces qui ouvrent sur la rue. Cette structure, complétée par l'analyse des textes, permet de replacer la demeure dans son contexte urbain.
Étiquette et distribution intérieure dans les maisons royales de la Renaissance
Authors: Jestaz Bertrand 
Published: August 2014

Étiquette et distribution intérieure dans les maisons royales de la Renaissance.
On ne peut étudier la distribution d'une résidence sans connaître les usages en matière de logement. Au début du XVIe siècle, le mot et la notion d'appartement n'existent pas : le roi ne dispose traditionnellement que d'une salle et d'une chambre, récemment complétée par une «garderobbe». C'est sous François Ier qu'apparaît le cabinet, sous Henri II l'antichambre. Les règlements adoptés par les derniers Valois révèlent donc l'existence d'une suite quasi classique (salle des gardes, antichambre, chambre, cabinet) qui prendra finalement le nom italien d'appartement. Henri III en 1585 tentera même de l'étendre encore en donnant à chaque pièce une vocation spécifique. Cette évolution explique la réforme imposée par Henri II au programme du nouveau Louvre et le doublement des logis royaux effectué à Fontainebleau par Charles IX. Plus généralement, elle devait amener l'abandon du plan centré et favoriser une disposition linéaire et des partis additifs qui marquent l'architecture du château français à l'aube du XVIIe siècle.
Le renard de Teumesse chez Antoninus Liberalis (Mét., XLI). Formes et structures d’une narration
Authors: Delattre Charles 
Published: August 2014

Pour la critique contemporaine, la notice XLI des Métamorphoses
d’Antoninus Liberalis, consacrée au renard de Teumesse, est un récit composé d’épisodes hétérogènes enchaînés de façon médiocre les uns aux autres. Il est possible de montrer au contraire qu’il s’agit d’un texte articulé en quatre volets qui se combinent les uns aux autres dans une architecture générale. On peut également montrer que certains énoncés dans le texte même restent extérieurs à cette organisation d’ensemble, ce qui a pour conséquence de modifier l’édition du texte de la notice en restant plus proche de la tradition manuscrite, et d’envisager la possiblité qu’il existe différents niveaux de composition et de lecture au sein d’un texte mythographique.
The Simple Analytics of Helicopter Money: Why It Works — Always
Authors: Buiter Willem H. 
Published: August 2014

Abstract
The paper offers a rigorous analysis of Milton Friedman’s parable of the ‘helicopter’ drop of money – a temporary fiscal stimulus funded through an increase in the stock of fiat base money that is never completely reversed in present discounted value (PDV) terms. A monetized fiscal stimulus is more expansionary than a debt-financed one because a monetized expansion of the Central Bank balance sheet is profitable: it relaxes the intertemporal budget constraint of the State – it creates fiscal space. It is up to the fiscal authority to make appropriate use of this fiscal space. Four conditions must be satisfied for a helicopter money drop to boost aggregate demand. First, it must not be reversed fully in PDV terms. Second, there must be benefits from holding fiat base money other than its pecuniary rate of return: that is, the interest rate on any additional base money issued is below the rate of return on the Central Bank’s assets. Third, fiat base money is irredeemable – an asset to the holder but not a liability to the issuer. Fourth, the price of money is positive. Given these conditions, there always exists – even in a permanent liquidity trap – a combination of monetary and fiscal policy actions that boosts private and/or public demand demand) – in principle without limit. Deflation, ‘lowflation’ and secular stagnation are therefore policy choices. Other conclusions are: (1) the increase in the monetary base need not be permanent for helicopter money to be effective; (2) Treasury debt cancellation by the Central Bank or the purchase by the Central Bank of perpetuities (with zero, negative or positive coupons) rather than finite maturity debt are fundamentally irrelevant policy actions. At most they have signaling value; (3) dropping perishable helicopter money will make it more effective if households are liquidity-constrained.
Klaarheid over het Clearing House
Authors: Veerman G.J. 
Published: August 2014

Klaarheid over het Clearing House
Bezien wordt wat het Clearing House voor Wetsevaluatie (CHW) heeft opgeleverd en of, en zo ja, hoe een CHW moet worden verankerd in het wetgevingskwaliteitsbeleid. De opbrengst is meer kennis: een empirisch onderbouwd schema van factoren die invloed kunnen hebben op de naleving en doelbereiking van wetten. Een meta-evaluatie leverde onder andere op dat wetten heel behoorlijk hun doel bereiken, dat er een sterk verband is tussen bekendheid, naleving en doelbereiking, en dat consultatie en gebruik van toezichts- en handhavingsbevoegdheden bijdragen aan naleving en doelbereiking. Een institutionele inbedding van kwaliteitszorg is nodig als tegenwicht tegen de druk zo snel mogelijk wetgeving te produceren tegen de laagste kosten. Voortdurende aanvulling van kennis en inzicht in het proces van wetgeving kan via het IAK worden georganiseerd, bij voorkeur aan de hand van thematisch onderzoek.
Ex-antestudies op de kaart
Authors: Klein Haarhuis C.M. , Smit M. 
Published: August 2014

Ex-antestudies op de kaart. Onderzoek naar beleidsvoornemens (2005-2011): aard, aantallen en wat ex-postevaluaties erover zeggen
In hoeverre is de toegenomen aandacht voor ex-ante-evaluatie, zowel in beleidskringen als in publicaties, terug te zien in de evaluatiepraktijk? Op basis van de uitkomsten van een recente door het WODC verrichte metastudie gaan we in deze bijdrage in op aard en omvang van 306 in de periode 2005-2011 voor de rijksoverheid verrichte ex-anteanalyses. Daarbij besteden we ook aandacht aan hun voorspellingskracht. We onderscheiden acht typen ex-anteanalyses. Combinaties van studietypen, kosten-batenanalyses en verkennende (quickscan) studies komen het meest voor. Van de bestudeerde analyses was 15% gevolgd door een latere evaluatie (ex durante of ex post). Redenen waarom latere evaluaties ontbreken, zijn dat het ex ante onderzochte beleid inmiddels van de baan is, of nog in de ontwerpfase verkeert. In sommige gevallen was het waarschijnlijk nog te vroeg voor evaluatie. Lang niet alle latere evaluaties sluiten aan op het ex-anteonderzoek. Wanneer dat wel het geval is, worden voorspellingen soms wel, soms deels en soms niet bevestigd. Aan het belang van zowel ex-ante- als ex-postonderzoek doen deze observaties niet af; bevindingen uit ex-postevaluaties over wat in het verleden of elders gewerkt heeft, zijn een onmisbare bron van kennis voor toekomstig ex-anteonderzoek en daarmee voor beleid en wetgeving.
Net radiation in a snow‐covered discontinuous forest gap for a range of gap sizes and topographic configurations
Authors: Seyednasrollah Bijan , Kumar Mukesh 
Published: August 2014

AbstractEstimating net radiation on the forest floor is crucial for predicting snowmelt recharge and for quantifying water yield from snow‐dominated forested watersheds. However, complex characteristics of radiation transfer in discontinuous forest gaps make this estimation challenging. This study quantifies net radiation within a forest gap for a range of gap sizes, slopes and aspects, and meteorological conditions. The spatial distribution of net radiation in the gap is found to be heterogeneous with southern and northern areas of the gap receiving minimum and maximum energy amounts, respectively. At a midlatitude site and for completely clear sky conditions in the snow season, results suggest that net radiation in the forest gap is minimum for gaps of size equal to half of the surrounding tree height. In contrast, when sky cloudiness in the snow season is considered, net radiation shows a monotonically increasing trend with gap size. Slope and aspect of forest gap floor also impact the net radiation and its variation with gap size. Net radiation is largest and smallest on steep south‐facing and north‐facing slopes, respectively. Variation of net radiation with slope and aspect is largest for larger gaps. Results also suggest that net radiation in north‐facing forest gaps is larger than in open areas for a longer duration in the snow season than in forest gaps on flat and south‐facing slopes. Since net radiation directly affects melt recharge and evaporation, these findings have implications on forest and water management, wildfire hazard, and forest health.
Proportion of opioid use due to compensated workers' compensation claims in Manitoba, Canada
Authors: Kraut Allen , Shafer Leigh Anne , Raymond Colette B. 
Published: August 2014

BackgroundThis study identifies the percentage of opioids prescribed for compensated workplace conditions in Manitoba, Canada and whether Workers Compensation Board (WCB) status is associated with higher prescription opioid doses.MethodsOpioid prescriptions for WCB recipients were linked with databases housed at the Manitoba Center for Health Policy. Duration of continuous opioid prescription and morphine equivalents (ME) per day (ME/D) were calculated for individuals age 18–65.ResultsOver the period from 1998 to 2010, 3.8% of the total opioid dosage of medication prescribed in the study population were prescribed to WCB recipients. WCB recipients accounted for 2.1% of the individuals prescribed opioids. In adjusted analyses WCB recipients were more likely to be prescribed over 120 ME/D (OR 2.06 95% CI, 1.58–2.69).ConclusionsWCB recipients account for a small, but significant amount of the total opioid prescribed in Manitoba. Manitoba's WCB population is a group at increased risk of being prescribed over 120 ME/day. Am. J. Ind. Med. 58:33–39, 2015. © 2014 The Authors. American Journal of Industrial Medicine Published by Wiley Periodicals, Inc.