bluuebunny/crossref_metadata_2025_split huggingface dataset:
An investigation of porosity–velocity relationships in faulted carbonates using outcrop analogues
Authors: Healy David , Neilson Joyce E. , Haines Thomas J. , Michie Emma A. H. , Timms Nicholas E. , Wilson Moyra E. J. 
Published: July 2014

Abstract

Porosity and permeability are notoriously difficult to predict in carbonates, especially prior to drilling when there is a lack of direct petrophysical data. The aim of this paper is to document the initial results of an integrated outcrop and laboratory study designed to investigate the relationships between pore systems and acoustic velocities in faulted Oligo-Miocene carbonates on the Mediterranean islands of Malta and Gozo. Depositional facies is shown to have a significant effect, with velocities in grain-dominated carbonates up to 1000 m s
−1
higher than those in micrite-dominated carbonates. Based on outcrop structural data, the fault zones can be separated into three architectural components: a fault core; an intensely damaged zone; and a weakly damaged zone, with the last passing into undamaged protolith. Our data suggest that only the fault core component can be identified using porosity–velocity data, with P-wave velocity (
V
p
) values of 5000–6500 m s
−1
at helium porosities of less than 5%. Our study is novel in that the prediction of elastic properties and acoustic velocities across fault zones is anticipated by linking laboratory-scale measurements with seismic-scale predictions through quantitative rock physics modelling.
BCMab1, A Monoclonal Antibody against Aberrantly Glycosylated Integrin α3β1, Has Potent Antitumor Activity of Bladder Cancer In Vivo
Authors: Li Chong , Yang Zhao , Du Ying , Tang Haidong , Chen Jun , Hu Deqing , Fan Zusen 
Published: July 2014

Abstract
Purpose: To identify a novel biomarker for bladder cancer targeting therapy.
Experimental Design: The human bladder cancer cell line T24 cells were used as immunogen to generate mouse monoclonal antibodies. We screened and identified a specific antibody BCMab1 against bladder cancer. We examined BCMab1 antigen expression in the patients with bladder cancer through immunohistochemical staining and investigated the BCMab1 antigen association with clinical severity. We detected the antitumor activity of BCMab1 antibody and investigated its therapeutic efficacy by subcutaneous and orthotopic bladder cancer models.
Results: We developed a new monoclonal antibody BCMab1 against bladder cancer that specifically recognized the aberrantly glycosylated Integrin α3β1 epitope on bladder cancer cells. Expression of the BCMab1 antigen was consistent with clinical severity and prognosis of bladder cancer. The glycosyltransferase GALNT1 could contribute to aberrant glycosylation of Integrin α3. The aberrant glycosylation of integrin α3–activated integrin signaling to initiate FAK activation. BCMab1 could block Integrin engagement to inhibit its signaling leading to cell-cycle arrest. In addition, BCMab1 enhanced FcγR-dependent antitumor activity in vivo.
Conclusions: BCMab1 antigen is a new biomarker for bladder cancer. BCMab1 antibody exhibited potent antitumor activity against bladder cancer in vivo. Clin Cancer Res; 20(15); 4001–13. ©2014 AACR.
Checklist of the marine and estuarine fishes of Madang District, <br />Papua New Guinea, western Pacific Ocean, with 820 new records
Authors: Fricke Ronald , Allen Gerald R. , Andréfouët Serge , Chen Wei-Jen , Hamel Mélanie A. , Laboute Pierre , Mana Ralph , Hui Tan Heok , Uyeno Daisuke 
Published: July 2014

A checklist of the marine and estuarine fishes of Madang District is presented, combining both previous and new records. After the recent PAPUA NIUGINI 2012 expedition, a total of 1337 species in 129 families have been recorded from the region. One species and one family is not native (Cichlidae: Oreochromis mossambicus), but has been introduced. The native fish fauna of Madang therefore consists of 1336 species in 128 families. The largest families are the Gobiidae, Labridae, Pomacentridae, Apogonidae, Serranidae, Blenniidae, Chaetodontidae, Syngnathidae and Muraenidae, Scorpaenidae and Lutjanidae, Myctophidae, Acanthuridae, Scaridae, Holocentridae, Carangidae, Pomacanthidae and Tetraodontidae, and Caesionidae. A total of 820 fish species (61.4 % of the total marine and estuarine fish fauna) are recorded from Madang for the first time. The fish fauna of Madang includes a total of 187 species of transitional waters and 1326 species in marine habitats. A total of 156 species of the marine or estuarine species also occurs in freshwater. Zoogeographically, 1271 species have a wide distribution range, most frequently a broad Indo-West Pacific distribution. Among the remaining species, only 8 are endemic to Madang District. Anthropogenic threats to the fish fauna and habitats of Madang District include extensive fishing in Madang Lagoon, sometimes with destructive fishing practices; the discharge of untreated sewage of human settlements, mining and industrial developments into the lagoon and nearby oceanic habitats; and destruction of mangrove habitats by extensive construction work on the shores. These anthropogenic threats may call for conservation and monitoring measures in the near future.
Spatial and Temporal Characteristics of Polarimetric Tornadic Debris Signatures
Authors: Van Den Broeke Matthew S. , Jauernic Sabrina T. 
Published: July 2014

AbstractNonmeteorological scatter, including debris lofted by tornadoes, may be detected using the polarimetric radar variables. For the 17 months from January 2012 to May 2013, radar data were examined for each tornado reported in the domain of an operational polarimetric Weather Surveillance Radar-1988 Doppler (WSR-88D). Characteristics of the tornadic debris signature (TDS) were recorded when a signature was present. Approximately 16% of all tornadoes reported in Storm Data were associated with a debris signature, and this proportion is shown to vary regionally. Signatures were more frequently seen with tornadoes that were rated higher on the enhanced Fujita (EF) scale, with tornadoes causing higher reported total property damage, with tornadoes that were closer to the radar and thus intercepted by the beam at lower altitude, and associated with tornadoes with greater total pathlength. Tornadic debris signatures were most common in spring, when more strong tornadoes occur, and in autumn, when natural debris is more available. Debris-signature areal extent is shown to increase consistently with EF-scale rating and tornado longevity. Vertical extent of a TDS is shown to be greatest for strong, long-lived tornadoes with large radii of damaging wind. Land cover is also shown to exhibit some control over TDS characteristics—in particular, a large percentage of tornadoes with substantial track over urban land cover exhibited a TDS and do so very quickly after reported tornadogenesis, as compared with tornadoes over other land-cover classifications. TDS characteristics over grassland and cropland tended to be similar.
What is the most suitable blood collection tube for glucose estimation?
Authors: Dimeski Goce , Yow Kong S , Brown Nigel N 
Published: July 2014

Objectives Glucose is one of the most frequently measured analytes in laboratories. Most recent studies on glucose stabilities confirm that the sodium fluoride/potassium oxalate (NaF/KOx) tube is far from the gold standard. Citrate tubes have been suggested as the preferred tube type by many institutions. Greiner has introduced a glucose-specific tube (Glucomedics) containing NaF/KOx, citrate, and EDTA to minimise glycolysis. The aim was to determine which tube would be the most suitable for accurate glucose estimation in a routine laboratory setting. Design and methods The study process involved three experiments: (a) participant comparison using lithium heparin plasma as the comparative sample; (b) stability study (0, 1, 2 and 4 h); and (c) minimal fill volume for the citrate and the Glucomedics tubes. Results The patient comparison study of lithium heparin plasma showed that EDTA, NaF/KOx, and both citrate and Glucomedics if corrected for dilutional factors produced acceptable results. The stability study up to 4 h showed that the Glucomedics tube was most effective in preventing clinically significant change in glucose concentration at a room temperature. Both citrate and Glucomedics need to be filled within 0.5 mL of the recommended fill volume for acceptable results. Conclusion The Glucomedics tube is the most suitable for minimising glycolysis. Further improvements to it (use of correct dilutional factor and the addition of gel separator) would make this tube the benchmark for the most accurate estimation, best diagnosis and patient care decisions.
System-level intersectoral linkages between the mental health and non-clinical support sectors: a qualitative systematic review
Authors: Whiteford Harvey , McKeon Gemma , Harris Meredith , Diminic Sandra , Siskind Dan , Scheurer Roman 
Published: July 2014

Objectives: Concerns about fragmented mental health service delivery persist, particularly for people with severe and persistent mental illness. The objective was to review evidence regarding outcomes attributed to system-level intersectoral linkages involving mental health services and non-clinical support services, and to identify barriers and facilitators to the intersectoral linkage process. Methods: A systematic, qualitative review of studies describing attempts to coordinate the activities of multiple service agencies at the policy, program or organisational level was conducted. Electronic databases Medline, PsycINFO and EMBASE were searched via OVID from inception to July 2012. Results: Of 1593 studies identified, 40 were included in the review – 26 in adult and 14 in vulnerable youth populations. Identified mechanisms to promote positive system-level outcomes included: interagency coordinating committees or intersectoral/interface workers engaged in joint service planning; formalised interagency collaborative agreements; a single care plan in which the responsibilities of all agencies are described; cross-training of staff to ensure staff culture, attitudes, knowledge and skills are complementary; service co-location; and blended funding initiatives to ensure funding aligns with program integration. Identified barriers included: adequacy of funding and technology; ensuring realistic workloads; overcoming ‘turf issues’ between service providers and disagreements regarding areas of responsibility; ensuring integration strategies are implemented as planned; and maintaining stakeholder enthusiasm. Conclusions: System-level intersectoral linkages can be achieved in various ways and are associated with positive clinical and non-clinical outcomes for services and clients. Some linkage mechanisms present greater implementation challenges than others (e.g. major technology upgrades or co-location in geographically remote areas). In some instances (e.g. co-location) alternative options may achieve equivalent benefits. Publication bias could not be discounted, and studies using high-quality research designs are scarce. The limited information base applicable to system-level integration argues strongly for the evaluation of the models that evolve in the rollout of the national Partners in Recovery initiative.
Reporting performance information in the public sector: the moral behind the (non)application of program budgeting in Greece
Authors: Cohen Sandra , Karatzimas Sotiris 
Published: July 2014

The article examines the timetable of the introduction and the sudden abandoning of program budgeting in Greece. The analysis is conducted through the lens of neo-institutional theory, organizational change theory and the resource dependency model. The framework developed is informed by archival data and the views of executives involved with the program as well as politicians. The findings suggest that subsequent institutional pressures deriving from the country’s resource dependency resulted in a re-prioritization of actions and therefore to the abandoning of the program budgeting project. Moreover, the analysis reveals that the cultivated culture inside a bureaucratic central government which gives rise to resistance to change and the poor diffusion of the new accounting philosophy would have hampered the success of the new system even if the plan had not been abandoned. Points for practitioners The application of program budgeting is expected to significantly assist public managers and politicians in better assessing the usefulness, the effectiveness and the efficiency of several central government functions. The present article provides insights into the first attempt to introduce program budgeting in Greece and highlights the difficulties faced during the process. The knowledge gained from the unsuccessful attempt to introduce program budgeting in Greece has important implications for understanding the factors that contribute to the failure of accounting change at central government level.
Low-complexity sparse reconstruction for high-resolution multi-static passive SAR imaging*
Authors: Mao Xinhua , Zhang Yimin D , Amin Moeness G 
Published: July 2014

Abstract
Bi-static passive synthetic aperture radar (SAR) systems using ground broadcast and wireless network signals suffer from a low spatial resolution due to the narrow bandwidths and low carrier frequencies. By exploiting multiple distributed illuminators, multi-static passive radar has the possibility of producing high-resolution SAR images. In this paper, a two-stage image formation approach, which combines the Fourier transform and sparse reconstruction strategies, is proposed to process multi-static SAR data. This method exploits the group sparsity of the sparse scene, i.e., the observations associated with different bi-static pairs share the same support of the sparse scene but correspond to aspect-dependent scattering coefficients. Such observations are described as a number of generally disjoint sub-bands in the two-dimensional spatial frequency domain. In each sub-band, the sampling satisfies the Nyquist criterion, whereas different sub-bands are sparsely distributed. In the proposed approach, Fourier-based reconstruction is applied to the sub-band data to produce the coarse-resolution images, which are then combined to produce a high-resolution image through the exploitation of sparse reconstruction techniques. The proposed approach greatly improves the imaging quality as compared to Fourier-based reconstruction, whereas it exhibits significant reduction of the computational complexity when compared to direct application of sparse reconstruction techniques. The exploitation of block sparsity-based techniques also permits practical treatment of the angle-dependent target scattering characteristics in SAR image reconstruction. The advantages of the proposed approach are delineated using analysis and simulations.
Safety and Efficacy of Aerobic Training in Patients With Cancer Who Have Heart Failure: An Analysis of the HF-ACTION Randomized Trial
Authors: Jones Lee W. , Douglas Pamela S. , Khouri Michel G. , Mackey John R. , Wojdyla Daniel , Kraus William E. , Whellan David J. , O'Connor Christopher M. 
Published: July 2014

Purpose To investigate the efficacy and safety of aerobic training (AT) in patients with cancer with medically stable heart failure (HF). Patients and Methods A retrospective analysis of 90 patients with cancer who have HF and who were randomly assigned to AT (n = 47) or guideline-based usual care (UC; n = 43) was performed. AT consisted of three supervised sessions per week at 20 to 45 minutes per session at 60% to 70% of heart rate reserve for 12 weeks followed by home-based sessions for 4 to 12 months. The primary end point was all-cause mortality and hospitalization. Secondary end points were other clinical events, safety, and change in exercise capacity (VO2peak) and health-related quality of life (HRQOL). Results Median follow-up was 35 months. In intention-to-treat (ITT) analyses, all-cause mortality or hospitalization at 2 years was 74% in the AT group compared with 67% in the UC group (adjusted hazard ratio [HR], 1.11; 95% CI, 0.69 to 1.77; P = .676). The incidence of cardiovascular mortality or cardiovascular hospitalization was significantly higher in the AT group compared with the UC group (41% v 67%; adjusted HR, 1.94; 95% CI, 1.12 to 3.16; P = .017). There were no differences in any VO2peak or HRQOL end points. In post hoc analyses based on adherence to AT, all-cause mortality and hospitalization was 66% in adherent patients (≥ 90 minutes per week) compared with 84% in nonadherent patients (< 90 minutes per week). Conclusion In ITT analyses, AT did not improve clinical outcomes in patients with cancer who had HF. Post hoc analyses suggested that patients not capable of adhering to the planned AT prescription may be at increased risk of clinical events.
Efficacy of Methylprednisolone on Pain, Fatigue, and Appetite Loss in Patients With Advanced Cancer Using Opioids: A Randomized, Placebo-Controlled, Double-Blind Trial
Authors: Paulsen Ørnulf , Klepstad Pål , Rosland Jan Henrik , Aass Nina , Albert Eva , Fayers Peter , Kaasa Stein 
Published: July 2014

Purpose Corticosteroids are frequently used in cancer pain management despite limited evidence. This study compares the analgesic efficacy of corticosteroid therapy with placebo. Patients and Methods Adult patients with cancer receiving opioids with average pain intensity ≥ 4 (numeric rating scale [NRS], 0 to 10) in the last 24 hours were eligible. Patients were randomly assigned to methylprednisolone (MP) 16 mg twice daily or placebo (PL) for 7 days. Primary outcome was average pain intensity measured at day 7 (NRS, 0 to 10); secondary outcomes were analgesic consumption (oral morphine equivalents), fatigue and appetite loss (European Organisation for Research and Treatment of Cancer–Quality of Life Questionnaire C30, 0 to 100), and patient satisfaction (NRS, 0 to 10). Results A total of 592 patients were screened; 50 were randomly assigned, and 47 were analyzed. Baseline opioid level was 269.9 mg in the MP arm and 160.4 mg in the PL arm. At day-7 evaluation, there was no difference between the groups in pain intensity (MP, 3.60 v PL, 3.68; P = .88) or relative analgesic consumption (MP, 1.19 v PL, 1.20; P = .95). Clinically and statistically significant improvements were found in fatigue (−17 v 3 points; P .003), appetite loss (−24 v 2 points; P = .003), and patient satisfaction (5.4 v 2.0 points; P = .001) in favor of the MP compared with the PL group, respectively. There were no differences in adverse effects between the groups. Conclusion MP 32 mg daily did not provide additional analgesia in patients with cancer receiving opioids, but it improved fatigue, appetite loss, and patient satisfaction. Clinical benefit beyond a short-term effect must be examined in a future study.
Refinement of Measurement Data of Thermocatalytic Sensor Exposed to Various Flammable Gases and Non-Binary Mixtures
Authors: Карелин  , Karelin A. 
Published: July 2014

The article considers a method of flammable gases concentration measurement. Experimental unit of thermocatalytic sensor and microcontrollerwith 12-bit ADChas been constructed. Output signal(mV)dependency on different concentrations
of flammable gases has been revealed. It is revealed that catalytic sensor sensitivity changes with temperature, and sensitivity change is unequal for different combustible gases. Thus, there is a possibility to bring results of measuring to % LEL by adding correcting coefficient Kp that characterizes reduction rate of sensing element sensitivity under temperature increase. Application of the method allowed to reduce measuring inaccuracy from 88% to 10% for hydrogen, and from 51% to 19% for hexane. The paper is related to flammable gases metrology.
Sources of Variation in the Net Value of Sugar Maple Trees: Implications for Tree Selection and Operations Management
Authors: Cockwell Malcolm , Caspersen John 
Published: July 2014

Abstract
The net value of hardwood trees (dollars per tree) is thought to increase with stem size for three reasons. First, large trees yield a greater volume (cubic meters) of logs, which tend to be larger than logs from small trees; second, large logs are more valuable (dollars per cubic meter) than small logs; and, third, large logs cost less (dollars per cubic meter) to process than small logs. Yet few studies have assessed both the cost of processing hardwood trees and the value of their products. In this article, we examine how the net value of sugar maple trees (Acer saccharum) varies with tree size and the presence of defects, such as fungi and seams. We quantify the gross value of firewood, lumber, and residues as well as the costs of harvesting and sawmilling. For each tree, we also calculate its net value to an integrated forestry company by subtracting costs from gross values. Our results confirm that large trees are more profitable than small trees but challenge current assumptions as to why. As expected, the volume and value of products are reduced by defects, while costs (dollars per cubic meter) are lower for larger trees. However, we found that gross value (dollars per cubic meter) does not vary with tree size, indicating that large trees yield more but not necessarily better products. The results of this study provide insight into how loggers can improve value recovery while limiting processing costs. These results also challenge the rationale behind silvicultural prescriptions that retain large trees based on the assumption that they produce greater volumes of higher-quality wood.
Marketing Territorial Aplicado al Mercado de Consumo en la Ciudad de Santa Fe (Argentina). Un Caso de Localización de un Empredimiento Gastronómico
Authors: Kosiak de Gesualdo Graciela Mabel , Modesto María Florencia 
Published: July 2014

A nivel de las planificaciones económicas, sociales, gubernamentales y empresariales, el conocimiento demográfico de la población, su estructura y su evolución, como así también los datos vinculados a la estructura econó- mica e institucional son de vital importancia. En el mundo en general, sobre todo en los países desarrollados, la innovación en el uso de la información llega de la mano de la tecnología de los Sistemas de Información Geográfica, conocidos como SIG o GIS. Esta nueva tecnología permite la representación geográfica de datos en función de coordenadas cartográficas y su utilización resulta fundamental para la toma de decisiones en las organizaciones, ya que estudios realizados han demostrado que aproximadamente el 90% de la información de las empresas tiene algún componente geográfico (Grimshaw, 1994:69). El Marketing Territorial o Geomarketing incluye una forma de segmentación de los mercados que utiliza criterios geográficos unidos a criterios demográficos (segmentación geodemográfica) para conocer con precisión pautas de comportamiento de los habitantes de microsegmentos geográ- ficos, localizar mercados potenciales, etc., permitiendo un análisis más sofisticado y eficiente de la información. Los fundamentos en los que se basa el Marketing Territorial no son nuevos, pero la aparición de tecnología de información aplicada, capaz de manipular datos georreferenciados, ha permitido ampliar y diversificar las aplicaciones de los SIG en el proceso de toma de decisiones y la planificación comercial.
Structure of large dsDNA viruses
Authors: Klose Thomas , Rossmann Michael G. 
Published: July 2014

Abstract
Nucleocytoplasmic large dsDNA viruses (NCLDVs) encompass an ever-increasing group of large eukaryotic viruses, infecting a wide variety of organisms. The set of core genes shared by all these viruses includes a major capsid protein with a double jelly-roll fold forming an icosahedral capsid, which surrounds a double layer membrane that contains the viral genome. Furthermore, some of these viruses, such as the members of the Mimiviridae and Phycodnaviridae have a unique vertex that is used during infection to transport DNA into the host.