bluuebunny/crossref_metadata_2025_split huggingface dataset:
Glycolysis-related five-gene signature correlates with prognosis and immune infiltration in gastric cancer
Authors: Meng Xiang-Yu , Yang Dong , Zhang Bao , Zhang Tao , Zheng Zhi-Chao , Zhao Yan 
Published: July 2024

BACKGROUND
Gastric cancer (GC) is one of the most common malignancies worldwide. Glycolysis has been demonstrated to be pivotal for the carcinogenesis of GC.
AIM
To develop a glycolysis-based gene signature for prognostic evaluation in GC patients.
METHODS
Differentially expressed genes correlated with glycolysis were identified in stomach adenocarcinoma data (STAD). A risk score was established through a univariate Cox and least absolute shrinkage and selection operator analysis. The model was evaluated using the area under the receiver operating characteristic curves. RNA-sequencing data from high- and low-glycolysis groups of STAD patients were analyzed using Cibersort algorithm and Spearman correlation to analyze the interaction of immune cell infiltration and glycolysis. Multiomics characteristics in different glycolysis status were also analyzed.
RESULTS
A five-gene signature comprising syndecan 2, versican, malic enzyme 1, pyruvate carboxylase and SRY-box transcription factor 9 was constructed. Patients were separated to high- or low-glycolysis groups according to risk scores. Overall survival of patients with high glycolysis was poorer. The sensitivity and specificity of the model in prediction of survival of GC patients were also observed by receiver operating characteristic curves. A nomogram including clinicopathological characteristics and the risk score also showed good prediction for 3- and 5-year overall survival. Gene set variation analysis showed that high-glycolysis patients were related to dysregulation of pancreas beta cells and estrogen late pathways, and low-glycolysis patients were related to Myc targets, oxidative phosphorylation, mechanistic target of rapamycin complex 1 signaling and G2M checkpoint pathways. Tumor-infiltrating immune cells and multiomics analysis suggested that the different glycolysis status was significantly correlated with multiple immune cell infiltration. The patients with high glycolysis had lower tumor mutational burden and neoantigen load, higher incidence of microsatellite instability and lower chemosensitivity. High glycolysis status was often found among patients with grade 2/3 cancer or poor prognosis.
CONCLUSION
The genetic characteristics revealed by glycolysis could predict the prognosis of GC. High glycolysis significantly affects GC phenotype, but the detailed mechanism needs to be further studied.
Metachronous multifocal carcinoma: A case report
Authors: Wan Dan-Dan , Li Xiao-Ju , Wang Xing-Ru , Liu Tian-Xi 
Published: July 2024

BACKGROUND
The incidence of multiple primary carcinomas (MPC) varies greatly, ranging from 0.73% to 11.70% in foreign countries, with duo-duplex carcinoma being the most common, trio-duplex carcinoma and above being rare, and simultaneous multigenic carcinoma being even rarer, accounting for 18.4% to 25.3% of the incidence of MPC. However, there is no report regarding patients presenting with simultaneous dual-origin carcinoma of the liver and colon and heterochronous pancreatic cancer.
CASE SUMMARY
We report a special case of multifocal carcinoma, in which one patient had a medical condition of primary liver and colon cancer and pancreatic cystadenocarcinoma 2 years after surgery. Through aggressive advanced fluorescent laparoscopic techniques, standardized immunotherapy, targeting, and chemotherapy, a better prognosis and a desirable survival period were achieved for the patient.
CONCLUSION
There is a need to clarify the nature of MPC through advanced surgical means to ensure better diagnosis and treatment.
Synthesis And Characterization Of Optical And Structural Properties Of Inorganic And Green Leaf Doped Sno Thin Films Deposited Using Spray Pyrolysis
Authors: N Ukwu C , E Ekpe J , N Nwachukwu A , P Obot E , C Okafor O , O Daniel T , C Umunna J , B Otah P , J Robert B , A Elekwa C , J Ifeanyichukwu B 
Published: July 2024

Dye-sensitized Nanohybrid ZnxSnyOz thin films were deposited on glass substrates using spray pyrolysis method. The dye extract from the leaves of tectona grandis was used. A concentration of 0.1M of Zn2+ and 1% was used respectively. Depositions were carried out at different substrate temperature of 50oC, 100oC, and 150oC. The effect Zn2+ ion and dye extract from tectona grandis leaves on optical and solid state properties of the films were examined and analysed. The result showed that the absorbance of the undoped SnO thin films at various substrate temperatures vary from about 0.1-0.7. The absorbance generally increased with deposition/ substrate temperature exhibiting a maximum for films deposited at 150oC. The average transmittance of both un-doped and Zn2+ doped SnO thin films at 350nm is above 90% regardless of the film thickness. The dye doped samples showed an improvement in optical transmission at 625nm. The reflectance spectra of all films exhibited a similar trend. Peak reflectance was observed at 350nm for un-doped and Zn2+ doped samples of SnO thin films while peak reflectance can be observed at 625nm for dye doped samples. It is also observed that the band gaps of the dye doped samples are lower: 1.55eV- 1.83eV than those of the Zn2+ doped samples: 1.60eV – 2.20eV. This showed that the incorporation of the dye shifted the fundamental absorption edge of the un-doped SnO thin films thus providing tuning effect of the band gap for device applications. The diffractograms of SnO doped Zn are characterized by relatively low intensity for all the samples irrespective of the doping concentration compared to the un-doped SnO samples. Obviously, the doping of SnO with 1% dye extracts modified the XRD patterns of the un-doped SnO samples. Substrate temperature also affected the structural properties of SnO:dye sample depicting increase in intensity vis-à-vis crystallinity of the films with increase in substrate temperature. The results equally indicate that there was an increase in the grain sizes that resulted in a decrease in energy badgap of the samples.
Some hand anthropometry among Babur/Bura and Kanuri ethnic groups of Borno State, Nigeria.
Authors: Ishaku B. , Timbuak J.A. , Hamman W.O. 
Published: July 2024

BACKGROUND AND AIM: The human hand is the most used and versatile part of the body, and its dimensions varies with age, sex and ethnic groups. Hand dimensions such as, hand length and hand breadth are useful in forensic and legal sciences. The aim of this study is to measure some hand anthropometry variation among Babur/Bura and Kanuri ethnic groups in Maiduguri, Borno state Nigeria.
METHODOLOGY: A total of eight hundred and one (801) subjects (401 males; 198 Babur/Bura, 203 Kanuri and 400 females; 198 Babur/Bura, 202 Kanuri) were recruited for this study. Parameters collected were: hand length (HL), palm length (PL), hand breadth (HB) and palm breadth (PB) using a palm print scanner (HP Deskjet 1515 model) and, compared between groups student’s t-test was used, discriminant function was used to predict sex. SPSS version 22.0 software was used for statistical analyses and P<0.05 was set as level of significance.
RESULTS: Data analyzed showed that, Babur/Bura and Kanuri males had higher (p<0.001) mean hand dimension values compared to their female counterparts. However, there was no difference (p>0.05) in hand dimensions between the male-to-male and female-to-female of both ethnic groups.
CONCLUSION: There was sexual dimorphism in hand dimensions amongst Babur/Bura and Kanuri ethnic groups, which, could be useful for determination of sex and provide more insight into biological variation with the inclusion of these groups.
Value Analysis, Value Engineering and Value Management in Global Competition
Authors: Brondoni Silvio M. 
Published: July 2024

Cost analysis is a method to enhance the costs efficiency by evaluating the corporate profitability. In today business environment of global competition, war pressures, new markets and demographics, firms are changing their approach to cost control. In fact, the strategic cost analysis provides useful information for the short and long-term decision-making in order to achieve the growth corporate goals. In the current phase of global competition (Global Shortage Management) corporations must adapt their strategic cost analysis (Value Analysis, Value Engineering or Value Management) to specific competitive policies adopted in certain markets, which may concern 'Planned Obsolescence', 'Total Quality Management (TQM)' or 'Zero Defects Productions' objectives
Green Transition and Industrial Ecosystems: the Impact of EU Taxonomy for Sustainable Activities
Authors: Rizzi Paolo , Turci Lorenzo 
Published: July 2024

In this paper, we review the literature on industrial ecosystems and EU Taxonomy of sustainable activities. We then measure the size, dynamics and specialisation of the industrial ecosystems in Italy - as defined by the European Commission. Subsequently, we try to assess how much different sectors will be involved in the Taxonomy of sustainable activities: Manufacturing, Transportation, Electricity and Water Supply are those strongly involved in terms of employees. EU Taxonomy will radically change in the near future the financial reporting requirements and strategic management actions in the corporate system towards green transition. Firms need to improve their level of knowledge of the Taxonomy and identify suitable actions in order to align with it.
Green Consumer Behaviour in Global Markets
Authors: Luckho Takesh , Gaya Yash Krishna , Veerapen Loganaden , Saulick Praveen 
Published: July 2024

The degradation of planet earth is no longer unknown to the world. The global emphasis on environmental sustainability has led to the emergence of Green Consumer Behaviour. Consumers are increasingly encouraged to adopt green products and services. However, green consumers remain a small market. This study investigates green consumer behaviour focusing on the influence of demographic variables. Using a quantitative research design, 398 participants were surveyed and eight hypotheses were tested. The findings reveal significant relationships between gender, education, income, and green consumer awareness and attitudes, but not age. This robust analysis was critically evaluated through the lens of established theories like the Theory of Planned Behaviour. Despite some statistical limitations, a green consumer decision model is proposed, and the study concludes with recommendations for educational campaigns and policy interventions to promote green consumer practices, providing a valuable resource for future research and practical initiatives in Mauritius.
ЯНГИ ЎЗБЕКИСТОН-КОРЕЯ РЕСПУБЛИКАСИ БИЛАН МУНОСАБАТЛАРИНИНГ ЯНГИ БОСҚИЧИ
Authors: Нурметова Фазилат 
Published: July 2024

Сўнгги йилларда Ўзбекистон жаҳондаги кўплаб мамлакатлар билан ташқи иқтисодий алоқалари кенгайиб бормоқда. Бу борада Ўзбекистон Корея Республикаси билан мустаҳкам алоқаларни йўлга қўйган. Мақолада Янги Ўзбекистон-Корея республикаси давлати билан муносабатларининг янги босқичи таҳлил қилинган бўлиб, Ўзбекистон билан Корея Республикаси ўртасида алоҳида стратегик шериклик тўғрисидаги Қўшма декларация сиёсий, савдо-иқтисодий, инвестициявий, молиявий-техник ва маданий-гуманитар соҳаларда иккала мамлакат ўртасидаги ўзаро ҳамжиҳатликни чуқурлаштиришга қаратилган Ўзбекистон- Корея Республикаси муносабатлари тарихида янги босқични бошлаб берганлиги баён қилинган.
Memahami Pesan Dakwah Dalam Siaran
Authors: Efendi Erwan , Perdana Fatwa , Azmi Fauzan 
Published: July 2024

Dakwah, which initially only used traditional media, has developed by incorporating elements of contemporary technology, such as radio and television. One of the modern media that can be used for preaching today is radio and television. The purpose of television is to attract people's attention to the content of the message. Television has the potential to be an attractive medium for communicating positive messages to society. contains religious messages commonly called da'wah. The superiority of da'wah conveyed through broadcast media is not the only factor that plays a role. In this study, content analysis was used. Likewise, a da'i who wants to utilize broadcast media must have a deep understanding of how to do so, including how to determine the methods and techniques of his da'wah. Because the use of inappropriate broadcast media will not only waste time and money, but will also complicate the distance between da'wah activities and the community.
Efektivitas Bahan Ajar Pragmatik Berbasis Experential Learning untuk Meningkatkan Kesantunan Berbahasa Mahasiswa
Authors: Dian Ramadan Lazuardi  , M. Syahrun Effendi  , Deserli Pajarada Wulan Rahmadan  , Reza Mareta Permata Sari  
Published: July 2024

This research aims to determine the effectiveness of Pragmatics teaching materials based on experiential learning. The method used is an experiment with a pretest-posttest design with control group research design. Data collection uses interviews and tests. The research population was students of the Indonesian Language and Literature Education Study Program, semester III of the 2023/2024 academic year who took Pragmatics. The samples in the research were classes A and B. Research sampling was carried out using the intact group technique which resulted in class A as the experimental class and class B as the control class. Data analysis techniques to determine the effectiveness of experiential learning-based Pragmatics teaching materials are carried out by analyzing pretest and posttest class learning outcomes using N-gain scores. Next, to determine the increase in language politeness in the control and experimental classes, a t-test was carried out using the SPSS program. The calculation obtained is that if the sig(2-tailed) value is <0.05, it can be said that students' language politeness has increased, there is a difference in the average language politeness of the experimental and control classes. The research results show that Pragmatics teaching materials based on experiential learning to improve students' language politeness based on the n-gain score and n-gain score percent are effective to use. Based on the independent samples test output table, it is known that the Sig. (2-tailed) is 0.000 < 0.05, thus there is a significant difference in effectiveness in the control and experimental classes after using Pragmatics teaching materials based on experiential learning. So it can be concluded that students' language politeness increases after using Pragmatics teaching materials based on experiential learning.
Molecular docking study of phytochemical compounds from Kustakudori ennai as a potential anti-alopecia treatment
Authors: Elangovan Nandhini , P Chakravarthi , S Kanimozhi 
Published: July 2024

Background:
In the case of alopecia, the scalp's hair may completely or partially lost. The 5--reductase enzyme has been inhibited as a recent prophylactic treatment. Diahydrotestosterone, a more potent metabolite of testosterone, is produced when the enzyme 5--reductase is inhibited.
Literature:
Kushtakudori ennai, Siddha poly herbal drug is used as a Alopecia medicine mentioned in the literature Prana rakshamirtha sindhu.This research aimed to test activity of 9 known compounds contained within the herbs of Kushtakudori ennai as anti-alopecia.
Methodology:
Utilizing molecular docking and the Auto doc program, functionality was determined on their interaction with the androgen receptor (PDB code 4K7a). The steps in the research process were: creating databases of androgen protein structures; creating and perfecting three-dimensional structures of compounds; utilizing Autodock 1.5.6 to dock molecules to the androgen receptor protein; and using the pkCSM tool to estimate ADME-Tox.
Observation and Inference:
Total of 9 bioactive lead compounds were retrieved from the ingredients present on the polyherbal siddha formulation. From the reported data of the herbs, the phytochemicals such as
Oleic acid, Chebuloside, Friedelin, Maslinic acid, Piperine, Isovitexin, Astragalin, Salsoline and Alangicine. The compound’s like Astragalin, Chebuloside, Friedelin and Piperine reveals maximum of four to five interactions with the bioactive residues present on the target androgen receptor. Other components such as Isovitexin, Salsoline, Maslinic acid and Alangicine revels maximum of three viable interactions with the target in comparison with standard drug Finasteride.
Conclusion:
Based on the results of the computational analysis it was concluded that the bio-active compound’s like Astragalin, Chebuloside, Friedelin, Piperine, Isovitexin, Salsoline, Maslinic acid and Alangicine reveals prominent interaction with active site of the receptor thereby it may hinder the binding of native ligand and also limit the follicle shrinkage and subsequent hair fall process. Hence it was concluded that the aforementioned phytocompounds may exerts promising anti-alopecia activity.
A Siddha Management of Attai vidal with internal and external medicines for Naalavibatha Punn (Varicose Ulcer): A Case Report
Authors: Christian CBS Bharath , Devi P Nirmala , Shiny S Ethel , J Jayalakshmi 
Published: July 2024

According to various classical Siddha literature, the varicose ulcer is compared with the symptoms of Naalavibatha punn / Naalasurrutu punn / Naalaviruvu punn. Treat varicose ulcers by prescribing Siddha internal medicines and external therapies. On August 5, 2022, a 48-year-old female patient attended the OPD of Santhigiri Siddha Medical College and Hospital, Trivandrum, with the following complaints: dilatation of veins, present in the right lower limb for 6 years; hyperpigmented lesion with itching and swelling above the medial malleolus of the right lower limb for 6 months; and an ulcer present above the medial malleolus for the last 3 months. She had a known case of varicose veins and had taken sclerotherapy three times but did not have satisfaction with the allopathic medication. The majority of the symptoms were significantly reduced in 60 days under the Siddha medications, such as a combination of Siddha preparation (Parangipattai Chooranam, Sangu Parpam, and Silasathu Parpam), Rasa gandhi mezhugu for internal, Padikara neer washing, wound dressing with Mathan thailam for external for 2 months, and attai vidal (leech application) done in 3 sittings in the gap of 10 days. No recurrence of any chronic varicose ulcer was observed during the 1 year of follow-up, and relevant preventive Siddha medication for Naalavibatha punn was given. The doctor advised the patient to do exercises that strengthen the legs and compression therapy. To summarize, the case report exhibited that Siddha leech therapy with both internal and external medications is very effective in the management of varicose ulcers.
Insilico Studies Unveiling the Hepatoprotective Potential of Morus alba Linn: Docking and ADMET Analysis
Authors: Lichade Abha , Deshmukh Aayushi , Nakhate Yashwant , Kalambe Pranali 
Published: July 2024

The goal of the drug discovery process is to search for new drug molecules which can bind to a specific target known to be involved in causing a disease. This study aims to identify potential inhibitors against the TGF-β-type-I receptor (PDB Id-1VJY) by developing ligands through molecular docking and ADMET-based virtual screening. The plant-based nature product database of Morus alba Linn is utilized for this purpose. The resultants hits, identified as actives were evaluated by molecular docking studies to get insight into their potential binding interaction with the target protein. 1-deoxynojirimycin (A1), Catechin (A2), Cyanidine-3-rutinoside (A3), Cyclomulberrin (A4), Kaempferol (A5), Kuwanon-G (A6), Morusin (A7), Mulberrin (A8), Mulberrofuran-G (A9), Quercetin-3-(6-malonylglucoside) (A10), Quercitrin (A11), Rutin (A12), were selected for the molecular docking.ADMET based virtual screening ligand/Compound (A1, A2, A4, A5, A7, A8, A9) passes the lipinski’s rule. Compound A4 (-10.7 kcal/mol), A5 (-10.4 kcal/mol) and A8 (-9.9 kcal/mol) had the highest binding affinity to the active site in TGF-β-type-I receptor. In conclusion, based on docking score and ADMET virtual screening, Cyclomulberrine (A4) (-10.7 kcal/mol) more affinity toward the TGF-β-type-I receptor that could be investigated further in the search for Hepatoprotective agent.
Determination of Minimal Inhibitory Concentration of Gel containing combination of Picrorhiza Kurroa and Ficus Benghalensis for Treatment of Periodontitis
Authors: Rathod Surekha , Kaule Supriya S , Bawankar Pranjali 
Published: July 2024

Background: The therapeutic effects of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. for treatment of chronic inflammatory diseases is well known. Objective: The purpose of the present study is assessment of the efficacy of gel containing combination of Picrorhiza kurroa Royle ex benth and Ficus benghalensis L. against periodontopathogens and hydroalcoholic extracts of Picrorhiza kurroa Royle ex benth (PK) and Ficus benghalensis L. (FB) against periodontopathogens. Material & Methods: The preparation of the herbal Water extracts, Alcohol extracts and Hydro Alcoholic extracts was done by Soxhlet extraction method. MIC of different extracts of PK and FB and its combination was determined. Results: The MIC of the PK water extract against Aggregatibacter actinomycetemcomitans (Aa) and Porphyromonas gingivalis (Pg) was 0.8 μg/ml. For Aa and Pg, the MIC of water extract of FB was 1.6 μg/ml and 6.25 μg/ml, respectively. The combination of PK and FB alcoholic extract was shown to have a MIC of 1.6 μg/ml. Conclusion: The presence of antibacterial activity could be confirmed in periodontopathogens species which were assayed in this study. However, the MIC for the species employed showed a very large range, and were mostly very high. Nevertheless, traditional knowledge might provide some leads to elucidate potential candidates for future development of new antibiotic agents.
The effect of an Indian traditional Ayurvedic formulation (Rasa-sindoor) on Parkinson disease mouse model
Authors: Halder Tamali , Gupta Sameer , Haldar Chandana , Das Parimal 
Published: July 2024

Ayurveda is a traditional medication system in India. Experimental validation of ayurvedic formulations to combat with progressive, non-curable diseases like cancer, neurodegenerative disorders and knowing their mode of action are of current interest. The present study was aimed to explore the effect of dietary supplement of Rasa-sindoor (RS), an organo-metallic derivative of mercury, on drug (MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced mouse model of Parkinson disease (PD). For this, mice were divided into three groups: (1) vehicle control (Normal saline treated), (2) Treated 1 (MPTP treated: 15mg/kg body weight, twice a day in 2 hours interval for 2 days, intraperitoneal injection) and (3) Treated 2 (MPTP: same as Treated 1 and Rasa Sindoor: 1gm/kg RS twice a day for 4 days). Total cellular RNA was extracted from sacrificed mice brain tissue and Immunohistochemistry (IHC) was performed for Tyrosine Hydroxylase (TH) in 100 µ section of mid-brain region to check dopaminergic neurodegeneration. IHC revealed reduced TH activity in Treated 1 and Treated 2 as compared to vehicle control while Treated 2 showed greater TH activity than that of Treated 1. This preliminary observation was followed by a microarray based gene expression analysis, which results differential expression of a new set of genes involving neurogenesis, growth cone formation and axon guidance, activation of latent precursor cells etc.; validated by semi-quantitative real time PCR. Our result suggests that RS is neuroprotective and its mode of action may be through prevention of cell apoptosis and activation of latent precursor cells and cell growth.