bluuebunny/crossref_metadata_2025_split huggingface dataset:
Recurrent acute liver failure due to NBAS deficiency: phenotypic spectrum, disease mechanisms, and therapeutic concepts
Authors: Staufner Christian , Haack Tobias B. , Köpke Marlies G. , Straub Beate K. , Kölker Stefan , Thiel Christian , Freisinger Peter , Baric Ivo , McKiernan Patrick J. , Dikow Nicola , Harting Inga , Beisse Flemming , Burgard Peter , Kotzaeridou Urania , Lenz Dominic , Kühr Joachim , Himbert Urban , Taylor Robert W. , Distelmaier Felix , Vockley Jerry , Ghaloul‐Gonzalez Lina , Ozolek John A. , Zschocke Johannes , Kuster Alice , Dick Anke , Das Anib M. , Wieland Thomas , Terrile Caterina , Strom Tim M. , Meitinger Thomas , Prokisch Holger , Hoffmann Georg F. 
Published: November 2015

AbstractBackgroundAcute liver failure (ALF) in infancy and childhood is a life‐threatening emergency and in about 50 % the etiology remains unknown. Recently biallelic mutations in NBAS were identified as a new molecular cause of ALF with onset in infancy, leading to recurrent acute liver failure (RALF).MethodsThe phenotype and medical history of 14 individuals with NBAS deficiency was studied in detail and functional studies were performed on patients’ fibroblasts.ResultsThe phenotypic spectrum of NBAS deficiency ranges from isolated RALF to a multisystemic disease with short stature, skeletal dysplasia, immunological abnormalities, optic atrophy, and normal motor and cognitive development resembling SOPH syndrome. Liver crises are triggered by febrile infections; they become less frequent with age but are not restricted to childhood. Complete recovery is typical, but ALF crises can be fatal. Antipyretic therapy and induction of anabolism including glucose and parenteral lipids effectively ameliorates the course of liver crises. Patients’ fibroblasts showed an increased sensitivity to high temperature at protein and functional level and a disturbed tethering of vesicles, pointing at a defect of intracellular transport between the endoplasmic reticulum and Golgi.ConclusionsMutations in NBAS cause a complex disease with a wide clinical spectrum ranging from isolated RALF to a multisystemic phenotype. Thermal susceptibility of the syntaxin 18 complex is the basis of fever dependency of ALF episodes. NBAS deficiency is the first disease related to a primary defect of retrograde transport. Identification of NBAS deficiency allows optimized therapy of liver crises and even prevention of further episodes.
ISDN2014_0025: REMOVED: Promising serum protein marker for early detection of Alzheimer's disease
Authors: Kumar Rahul , Gupta Abhishek , Sahu Vishal , Singh Amrendra Pratap , Kumar Suresh , Singh Kusum , Dey A.B. , Dey Sharmistha 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0028: REMOVED: Targeting miR‐155 restores dysfunctional microglia and ameliorates disease in the SOD1 model of ALS
Authors: Butovsky Oleg , Jedrychowski Mark P. , Cialic Ron , Murugaiyan Gopal , Wu Pauline M. , Doykan Camille E. , Fanek Zain , Greco David J. , Kiner Olga , Lawson Robert J. , Frosch Matthew P. , Pochet Nathalie , Krichevsky Anna M. , Gygi Steven P. , Berry James , Cudkowicz Merit E. , Weiner Howard L. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0031: REMOVED: N‐acetylcysteine can alter 3,4‐methylenedioxymethamphetamine‐induced apoptosis in hippocampi of male rats
Authors: Asl Sara Soleimani , Mehdizadeh Mehdi 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0036: REMOVED: Craniofacial development is fine tuned by Sox2
Authors: Mandalos Nikolaos , Rhinn Muriel , Granchi Zoraide , Mitsiadis Thimios , Economides Aris N. , Dollé Pascal , Remboutsika Eumorphia 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0041: REMOVED: Neuropsychological deficits associated to cortical visual impairments
Authors: Chokron Sylvie , Cavezian Céline , Gueguen Marc , Caetta Florent 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0069: REMOVED: Identification of shared and distinct electrophysiological markers of ASD, ADHD and ASD+ADHD
Authors: Tye Charlotte , Asherson Philip , Ashwood Karen L. , Azadi Bahare , Bolton Patrick , McLoughlin Grainne 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0078: REMOVED: Fibronectin blocks the recovery of spinal cord injury by increasing P2Y1 receptor level
Authors: Xia Maosheng 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0120: REMOVED: Meranzin hydrate exhibits anti‐depressive and prokinetic‐like effects through regulation of the shared alpha2‐adrenoceptor in the brain‐gut axis of rats in the forced swimming test
Authors: Ying Xie , Xi Huang , Yuqian Bai 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0152: REMOVED: Behavioral effect of DNQX, AMPA receptor antagonist, on repetitive spreading depression in juvenile rats
Authors: Lotfinia Ahmad Ali 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0193: REMOVED: Beneficial effects of 17‐beta‐estradiol: A therapeutic potential drug for Alzheimer's disease
Authors: Kumar Pardeep , Kale R.K. , Baquer N.Z. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0288: REMOVED: Segmental and regional differences in the neuronal expression of putative leech Hox genes during embryonic development
Authors: Gharbaran Rajendra 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0297: REMOVED: Long‐lasting therapeutic actions of fibroblast growth factor 2 in a model of brain injury associated with very premature birth
Authors: Salmaso Natalina , Kim Janice , Saenz Jon‐Michael , Davis‐Cooper Shelby , Schwartz Michael L. , Vaccarino Flora M. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0310: REMOVED: Research of the rat's behavior using fetal valproate syndrome model
Authors: Rogozinskaya E.Ya. , Gedzun V.R. , Malyshev A.V. , Dubynin V.A. 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
ISDN2014_0316: REMOVED: New research priorities of the National Institute on Drug Abuse (NIDA): Cannabis effects on brain development
Authors: Wu Da‐Yu 
Published: November 2015

This article has been removed: please see Elsevier Policy on Article Withdrawal (https://www.elsevier.com/about/our‐business/policies/article‐withdrawal)This meeting abstract has been removed by the Publisher. Due to an administrative error, abstracts that were not presented at the ISDN 2014 meeting were inadvertently published in the meeting's abstract supplement. The Publisher apologizes to the authors and readers for this error.
Development of an alert system for subjects with paroxysmal atrial fibrillation
Authors: Thuraisingham R.A. 
Published: November 2015

AbstractBackgroundKnowledge of the onset of atrial fibrillation (AF) episodes in patients with paroxysmal atrial fibrillation (PAF) will enable them to better manage this condition. Current advances in mobile technology allow RR interval data to be obtained in real time. An analysis technique using RR interval data is presented with a view to alert a subject before a PAF episode.MethodThe method is based on a time series of standard deviation and 0.99 quantile values of the spectral entropy, constructed from RR data. The RR data are taken from three time periods. The first time period has no occurrences of AF for 45 min to either side of the time period. The second time period just precedes an AF attack. Both of these are of thirty minutes duration. The third time period of approximately 5 min follows the second, and is when AF occurs.ResultsTwenty‐two PAF subjects were studied and in all cases there was a steady increase in the values of these indices as the onset of the AF attack approached.ConclusionThis method of analysis of RR interval data shows potential use to alert a PAF subject before the onset of an AF episode.
Power Plays
Authors: Carnegie Allison 
Published: November 2015

Coercive diplomacy - the use of threats and assurances to alter another state's behavior - is indispensable to international relations. Most scholarship has focused on whether and when states are able to use coercive methods to achieve their desired results. However, employing game-theoretic tools, statistical modeling, and detailed case study analysis, Power Plays builds and tests a theory that explains how states develop strategies of coercive diplomacy, how their targets shield themselves from these efforts, and the implications for interstate relations. Focusing on the World Trade Organization, Power Plays argues that coercive diplomacy often precludes cooperation due to fears of exploitation, but that international institutions can solve these problems by convincing states to eschew certain tools for coercive purposes.
Effects of three-dimensionality on instability and turbulence in a frontal zone
Authors: Arobone Eric , Sarkar Sutanu 
Published: November 2015

Linear stability analysis and direct numerical simulation are used to investigate the evolution of a symmetrically unstable uniform frontal zone. Simulations in a three-dimensional computational domain capable of resolving near-symmetric currents develop strong nonlinearities without the emergence of pure symmetric instability. Linear stability analysis demonstrates that for $ft>1$ ( $f$ is the Coriolis parameter and $t$ denotes time) the flow generates strongly asymmetric structures which become nearly symmetric when $ft\gg 1$. Unlike the currents generated during pure symmetric instability, near-symmetric instability generates currents that do not align with isopycnals. This greatly modifies their energetics and evolution, leading to regions of the flow that are unstable to gravitational instability and energized by the reservoir of available potential energy. A high-resolution simulation demonstrates the flow evolution from near-symmetric currents to secondary shear-convective instabilities and finally, through tertiary instabilities, to fully three-dimensional turbulence. The effect of this sequence of instabilities is quantified through velocity and vorticity statistics as well as budgets for turbulent kinetic and potential energy. It is not until $ft\sim 10$ that the energy source for fluctuations is primarily shear, in contrast to the purely symmetric instability which draws its energy exclusively from shear production.
Coping strategies for food insecurity among adolescent girls during the lean season in East Nusa Tenggara, Indonesia: a qualitative study
Authors: Fatmaningrum Dewi , Roshita Airin , Februhartanty Judhiastuty 
Published: November 2015

AbstractOne in eight people suffer from chronic hunger, leading to an insecure food situation. Chronic hunger mostly occurs in developing countries and includes adolescent girls. Our qualitative study, with data collected in December 2012, provided the results of an exploration of the experiences and strategies implemented by fifteen adolescent girls who tried to cope with their condition of living in food-insecure families. The age of the girls ranged from 10 to 19 years. Their coping strategies were grouped into self-initiated and parent-initiated strategies. Self-initiated coping strategies that were the girls’ own initiatives included eating only rice without any vegetables or side dish, eating less-desirable food, reducing portion size, skipping meals, saving pocket money and earning money to buy food. The parent-initiated coping strategies that were initiated by the parents and followed by the girls included selling their own field produce and livestock, asking for food, borrowing food and storing maize for 6 months up to 1 year. These results show that adolescent girls living in food-insecure areas implement several coping strategies in severe conditions, which parents may not be aware of, and such conditions may compromise their growth and health. The acknowledgement of such coping strategies and the girls’ food insecurity condition can lead to a useful and suitable food insecurity alleviation programme for the girls and their families.
A pilot study to determine whether using a lightweight, wearable micro-camera improves dietary assessment accuracy and offers information on macronutrients and eating rate
Authors: Pettitt Claire , Liu Jindong , Kwasnicki Richard M. , Yang Guang-Zhong , Preston Thomas , Frost Gary 
Published: November 2015

AbstractA major limitation in nutritional science is the lack of understanding of the nutritional intake of free-living people. There is an inverse relationship between accuracy of reporting of energy intake by all current nutritional methodologies and body weight. In this pilot study we aim to explore whether using a novel lightweight, wearable micro-camera improves the accuracy of dietary intake assessment. Doubly labelled water (DLW) was used to estimate energy expenditure and intake over a 14-d period, over which time participants (n 6) completed a food diary and wore a micro-camera on 2 of the days. Comparisons were made between the estimated energy intake from the reported food diary alone and together with the images from the micro-camera recordings. There was an average daily deficit of 3912 kJ using food diaries to estimate energy intake compared with estimated energy expenditure from DLW (P=0·0118), representing an under-reporting rate of 34 %. Analysis of food diaries alone showed a significant deficit in estimated daily energy intake compared with estimated intake from food diary analysis with images from the micro-camera recordings (405 kJ). Use of the micro-camera images in conjunction with food diaries improves the accuracy of dietary assessment and provides valuable information on macronutrient intake and eating rate. There is a need to develop this recording technique to remove user and assessor bias.
Predicting global geographical distribution of Lolium rigidum (rigid ryegrass) under climate change
Authors: CASTELLANOS-FRÍAS E. , GARCIA DE LEÓN D. , BASTIDA F. , GONZALEZ-ANDUJAR J. L. 
Published: November 2015

SUMMARYLolium rigidum L. (rigid ryegrass) is one of the most extensive and harmful weeds in winter cereal crops. A bioclimatic model for this species was developed using CLIMEX. The model was validated with records from North America and Oceania and used to assess the global potential distribution of L. rigidum under the current climate and under two climate change scenarios. Both scenarios represent contrasting temporal patterns of economic development and carbon dioxide (CO2) emissions. The projections under current climatic conditions indicated that L. rigidum does not occupy the full extent of the climatically suitable area available to it. Under future climate scenarios, the suitable potential area increases by 3·79% in the low-emission CO2 scenario and by 5·06% under the most extreme scenario. The model's projection showed an increase in potentially suitable areas in North America, Europe, South America and Asia; while in Africa and Oceania it indicated regression. These results provide the necessary knowledge for identifying and highlighting the potential invasion risk areas and for establishing the grounds on which to base the planning and management measures required.
Chiral discrimination in NMR spectroscopy
Authors: Buckingham A. David 
Published: November 2015

AbstractNuclear magnetic resonance is the most important form of molecular spectroscopy in chemistry and biochemistry but it is normally blind to chirality. It was predicted in 2004 that precessing nuclear spins in chiral molecules in a liquid in a strong magnetic field induce a rotating electric polarization that is of opposite sign for enantiomers. This polarization arises from the distortion of the electronic structure by the nuclear magnetic moment in the presence of the strong magnetic field and is equivalent to the linear effect of an electric field on the nuclear shielding tensor. The polarization is strongly enhanced in dipolar molecules through the partial orientation of the permanent dipole through the antisymmetric part of the nuclear magnetic shielding tensor. Alternatively, an applied electric field will induce a chirally sensitive magnetization perpendicular to the field and to the nuclear spin. Progress towards the experimental realization of chiral discrimination by NMR is assessed.
Unresolved questions in human copper pump mechanisms
Authors: Wittung-Stafshede Pernilla 
Published: November 2015

AbstractCopper (Cu) is an essential transition metal providing activity to key enzymes in the human body. To regulate the levels and avoid toxicity, cells have developed elaborate systems for loading these enzymes with Cu. Most Cu-dependent enzymes obtain the metal from the membrane-bound Cu pumps ATP7A/B in the Golgi network. ATP7A/B receives Cu from the cytoplasmic Cu chaperone Atox1 that acts as the cytoplasmic shuttle between the cell membrane Cu importer, Ctr1 and ATP7A/B. Biological, genetic and structural efforts have provided a tremendous amount of information for how the proteins in this pathway work. Nonetheless, basic mechanistic-biophysical questions (such as how and where ATP7A/B receives Cu, how ATP7A/B conformational changes and domain–domain interactions facilitate Cu movement through the membrane, and, finally, how target polypeptides are loaded with Cu in the Golgi) remain elusive. In this perspective, unresolved inquiries regarding ATP7A/B mechanism will be highlighted. The answers are important from a fundamental view, since mechanistic aspects may be common to other metal transport systems, and for medical purposes, since many diseases appear related to Cu transport dysregulation.
Targeting caspase-6 and caspase-8 to promote neuronal survival following ischemic stroke
Authors: Shabanzadeh A P , D'Onofrio P M , Monnier P P , Koeberle P D 
Published: November 2015

AbstractPrevious studies show that caspase-6 and caspase-8 are involved in neuronal apoptosis and regenerative failure after trauma of the adult central nervous system (CNS). In this study, we evaluated whether caspase-6 or -8 inhibitors can reduce cerebral or retinal injury after ischemia. Cerebral infarct volume, relative to appropriate controls, was significantly reduced in groups treated with caspase-6 or -8 inhibitors. Concomitantly, these treatments also reduced neurological deficits, reduced edema, increased cell proliferation, and increased neurofilament levels in the injured cerebrum. Caspase-6 and -8 inhibitors, or siRNAs, also increased retinal ganglion cell survival at 14 days after ischemic injury. Caspase-6 or -8 inhibition also decreased caspase-3, -6, and caspase-8 cleavage when assayed by western blot and reduced caspase-3 and -6 activities in colorimetric assays. We have shown that caspase-6 or caspase-8 inhibition decreases the neuropathological consequences of cerebral or retinal infarction, thereby emphasizing their importance in ischemic neuronal degeneration. As such, caspase-6 and -8 are potential targets for future therapies aimed at attenuating the devastating functional losses that result from retinal or cerebral stroke.