bluuebunny/crossref_metadata_2025_split huggingface dataset:
Wormholes in the axiverse, and the species scale
Authors: Martucci Luca , Risso Nicolò , Valenti Alessandro , Vecchi Luca 
Published: July 2024

Abstract
We analyze a large class of four-dimensional $$ \mathcal{N} $$
N
= 1 low-energy realizations of the axiverse satisfying various quantum gravity constraints. We propose a novel upper bound on the ultimate UV cutoff of the effective theory, namely the species scale, which only depends on data available at the two-derivative level. Its dependence on the moduli fields and the number N of axions matches expectations from other independent considerations. After an assessment of the regime of validity of the effective field theory, we investigate the non-perturbative gravitational effects therein. We identify a set of axionic charges supported by extremal and non-extremal wormhole configurations. We present a universal class of analytic wormhole solutions, explore their deformations, and analyze the relation between wormhole energy scales and the species scale. The connection between these wormholes and a special subclass of BPS fundamental instantons is discussed, and an argument in favor of the genericity of certain axion-dependent effective superpotentials is provided. We find a lower bound increasing with N ≫ 1 on the Gauss-Bonnet coefficient, resulting in an exponential suppression of non-extremal wormhole effects. Our claims are illustrated and tested in concrete string theory models.
Bending performance of cross-laminated timber constructed from fibre-managed Eucalyptus nitens under short-term and long-term serviceability loads
Authors: Liang Yingwei , Taoum Assaad , Kotlarewski Nathan , Chan Andrew 
Published: July 2024

AbstractCross-laminated timber (CLT) has become a notable building material due to its structural efficiency, reliability and sustainability. In this study, the bending performance of three-layered CLT constructed from fibre-managed Eucalyptus nitens (E. nitens) was investigated under short-term and long-term loadings. Linear-elastic four-point bending testing was used to determine the maximum serviceability loading capacity before they reached the suggested deflection limits. A pilot study was conducted to investigate the creep behaviour of E. nitens CLT through long-term bending tests in a controlled environmental room. The study suggested that E. nitens CLT has higher serviceability loading capacity and lower creep ratio compared to CLT made from strength-class C24 spruce. The investigations of various configurations of E. nitens CLT panels based on structural grades implemented in top, cross, and bottom layers have revealed different short-term and long-term bending performances. The grade of transverse layers has been found to be the most important factor in improving the bending creep performance of E. nitens CLT. Two modelling equations were employed to perform curve fitting on the experimental creep ratio with time. The conventional power-law modelling tends to underestimate the longer-term creep ratio when compared to a recently developed nonlinear regression modelling equation that takes environmental conditions into account. The mean estimated creep ratio after 50 years was 1.77 for E. nitens CLT, and 1.89 for the C24 spruce CLT. The present study is a pilot investigation to increase the understanding of performance of the newly developed CLT made from fibre-managed plantations E. nitens, with particular emphasis on its creep behaviour. The results of this study provide valuable contributions for future research in this field, and ongoing commercial production of E. nitens CLT.
AI and the iterable epistopics of risk
Authors: Crabtree Andy , McGarry Glenn , Urquhart Lachlan 
Published: July 2024

AbstractThe risks AI presents to society are broadly understood to be manageable through ‘general calculus’, i.e., general frameworks designed to enable those involved in the development of AI to apprehend and manage risk, such as AI impact assessments, ethical frameworks, emerging international standards, and regulations. This paper elaborates how risk is apprehended and managed by a regulator, developer and cyber-security expert. It reveals that risk and risk management is dependent on mundane situated practices not encapsulated in general calculus. Situated practice surfaces ‘iterable epistopics’, revealing how those involved in the development of AI know and subsequently respond to risk and uncover major challenges in their work. The ongoing discovery and elaboration of epistopics of risk in AI (a) furnishes a potential program of interdisciplinary inquiry, (b) provides AI developers with a means of apprehending risk, and (c) informs the ongoing evolution of general calculus.
Central elements in the $$\textrm{SL}_d$$-skein algebra of a surface
Authors: Bonahon Francis , Higgins Vijay 
Published: July 2024

AbstractThe $$\textrm{SL}_d$$

SL
d

-skein algebra $$\mathcal {S}^q_{\textrm{SL}_d}(S)$$

S

SL
d

q

(
S
)

of a surface S is a certain deformation of the coordinate ring of the character variety consisting of flat $$\textrm{SL}_d$$

SL
d

-local systems over the surface. As a quantum topological object, $$\mathcal {S}^q_{\textrm{SL}_d}(S)$$

S

SL
d

q

(
S
)

is also closely related to the HOMFLYPT polynomial invariant of knots and links in $${\mathbb {R}}^3$$

R

3

. We exhibit a rich family of central elements in $$\mathcal {S}^q_{\textrm{SL}_d}(S)$$

S

SL
d

q

(
S
)

that appear when the quantum parameter q is a root of unity. These central elements are obtained by threading along framed links certain polynomials arising in the elementary theory of symmetric functions, and related to taking powers in the Lie group $$\textrm{SL}_d$$

SL
d

.
On the char front temperature of beech (Fagus sylvatica)
Authors: Pečenko Robert , Knez Nataša , Hozjan Tomaž , Šejna Jakub , Cabová Kamila , Turk Goran 
Published: July 2024

AbstractThe article investigates the charring and the char front temperature of beech, the most widespread hardwood species in Central Europe. The current Eurocode standard EN 1995-1-2 specifies the char front temperature to be 300 $$^{\circ }$$

∘

C, albeit this determination primarily applies to softwood species. Consequently, this article aims to examine whether this assumption applies to beech. Through advanced experimental analysis and numerical modelling, it was determined that the char front temperature for beech exceeds 300 $$^{\circ }$$

∘

C. This finding represents crucial information for the correct validation of fire-resistant design for structural elements made of beech. Moreover, it lays the groundwork for improving simplified methods of fire design, particularly for a more accurate determination of the charring depth.
First-in-human evaluation of 6-bromo-7-[11C]methylpurine, a PET tracer for assessing the function of multidrug resistance-associated proteins in different tissues
Authors: Mairinger Severin , Jackwerth Matthias , Chalampalakis Zacharias , Rausch Ivo , Weber Maria , Wölfl-Duchek Michael , Pracher Lena , Nics Lukas , Pahnke Jens , Langsteger Werner , Hacker Marcus , Zeitlinger Markus , Langer Oliver 
Published: July 2024

Abstract
Purpose
Multidrug resistance-associated protein 1 (MRP1) is a transport protein with a widespread tissue distribution, which has been implicated in the pathophysiology of Alzheimer’s and chronic respiratory disease. PET with 6-bromo-7-[11C]methylpurine ([11C]BMP) has been used to measure MRP1 function in rodents. In this study, [11C]BMP was for the first time characterised in humans to assess the function of MRP1 and other MRP subtypes in different tissues.

Methods
Thirteen healthy volunteers (7 men, 6 women) underwent dynamic whole-body PET scans on a long axial field-of-view (LAFOV) PET/CT system after intravenous injection of [11C]BMP. Three subjects of each sex were scanned a second time to assess reproducibility. Volumes of interest were outlined for MRP-expressing tissues (cerebral cortex, cerebellum, choroid plexus, retina, lungs, myocardium, kidneys, and liver). From the time-activity curves, the elimination rate constant (kE, h− 1) was derived as a parameter for tissue MRP function and its test-retest variability (TRTV, %) was calculated. Radiation dosimetry was calculated using the Medical Internal Radiation Dose (MIRD) methodology.

Results
Mean kE and corresponding TRTV values were: cerebral cortex: 0.055 ± 0.010 h− 1 (− 4 ± 24%), cerebellum: 0.033 ± 0.009 h− 1 (1 ± 39%), choroid plexus: 0.292 ± 0.059 h− 1 (0.1 ± 16%), retina: 0.234 ± 0.045 h− 1 (30 ± 38%), lungs: 0.875 ± 0.095 h− 1 (− 3 ± 11%), myocardium: 0.641 ± 0.105 h− 1 (11 ± 25%), kidneys: 1.378 ± 0.266 h− 1 (14 ± 16%), and liver: 0.685 ± 0.072 h− 1 (7 ± 9%). Significant sex differences were found for kE in the cerebellum, lungs and kidneys. Effective dose was 4.67 ± 0.18 µSv/MBq for men and 4.55 ± 0.18 µSv/MBq for women.

Conclusion
LAFOV PET/CT with [11C]BMP potentially allows for simultaneous assessment of MRP function in multiple human tissues. Mean TRTV of kE in different tissues was in an acceptable range, except for the retina. The radiation dosimetry of [11C]BMP was in the typical range of 11C-tracers. LAFOV PET/CT holds great potential to assess at a whole-body, multi-tissue level molecular targets relevant for drug disposition in humans.

Trial registration
EudraCT 2021-006348-29. Registered 15 December 2021.
Targeting of immune checkpoint regulator V-domain Ig suppressor of T-cell activation (VISTA) with 89Zr-labelled CI-8993
Authors: Burvenich Ingrid Julienne Georgette , Wichmann Christian Werner , McDonald Alexander Franklin , Guo Nancy , Rigopoulos Angela , Huynh Nhi , Vail Mary , Allen Stacey , O’Keefe Graeme Joseph , Scott Fiona Elizabeth , Soikes Raul , Angelides Steven , Roemeling Reinhard von , Scott Andrew Mark 
Published: July 2024

Abstract
Background
CI-8993 is a fully human IgG1κ monoclonal antibody (mAb) that binds specifically to immune checkpoint molecule VISTA (V-domain Ig suppressor of T-cell activation). Phase I safety has been established in patients with advanced cancer (NCT02671955). To determine the pharmacokinetics and biodistribution of CI-8993 in patients, we aimed to develop 89Zr-labelled CI-8993 and validate PET imaging and quantitation in preclinical models prior to a planned human bioimaging trial.

Methods
CI-8993 and human isotype IgG1 control were conjugated to the metal ion chelator p-isothiocyanatobenzyl-desferrioxamine (Df). Quality of conjugates were assessed by SE-HPLC, SDS-PAGE, and FACS. After radiolabelling with zirconium-89 (89Zr), radioconjugates were assessed for radiochemical purity, immunoreactivity, antigen binding affinity, and serum stability in vitro. [89Zr]Zr-Df-CI-8993 alone (1 mg/kg, 4.6 MBq) or in combination with 30 mg/kg unlabelled CI-8993, as well as isotype control [89Zr]Zr-Df-IgG1 (1 mg/kg, 4.6 MBq) were assessed in human VISTA knock-in female (C57BL/6 N-Vsirtm1.1(VSIR)Geno, huVISTA KI) or control C57BL/6 mice bearing syngeneic MB49 bladder cancer tumours; and in BALB/c nu/nu mice bearing pancreatic Capan-2 tumours.

Results
Stable constructs with an average chelator-to-antibody ratio of 1.81 were achieved. SDS-PAGE and SE-HPLC showed integrity of CI-8993 was maintained after conjugation; and ELISA indicated no impact of conjugation and radiolabelling on binding to human VISTA. PET imaging and biodistribution in MB49 tumour-bearing huVISTA KI female mice showed specific localisation of [89Zr]Zr-Df-CI-8993 to VISTA in spleen and tumour tissues expressing human VISTA. Specific tumour uptake was also demonstrated in Capan-2 xenografted BALB/c nu/nu mice.

Conclusions
We radiolabelled and validated [89Zr]Zr-Df-CI-8993 for specific binding to huVISTA in vivo. Our results demonstrate that 89Zr-labelled CI-8993 is now suitable for targeting and imaging VISTA expression in human trials.

Graphical Abstract
Magnetic resonance arthrography with positional manoeuvre for the diagnosis of synovial fold of posterior shoulder joint capsule
Authors: Keles Papatya , Ogul Hayri , Tuncer Kutsi , Sakci Zakir , Ay Mutlu , Kantarci Mecit 
Published: July 2024

Abstract

Objectives
The objective of this study is to prospectively assess the effectiveness of shoulder magnetic resonance (MR) arthrograms with positional manoeuvres in detecting posterior synovial folds.

Methods
Two radiologists independently assessed all axial MR arthrograms in internal rotation, neutral position, and external rotation for the presence of a posterior synovial fold. The diagnostic performances of the MR arthrograms were then compared, with results validated through arthroscopy.

Results
Arthroscopy was performed on 81 of the 150 patients included in the study. A posterior synovial fold was identified arthroscopically in eleven of these patients. Measurements of the posterior synovial fold obtained in external rotation and the neutral position of the arm showed a significant correlation with arthroscopic results (p < 0.05). For detecting the posterior synovial fold with arthroscopic correlation, the sensitivity and specificity values for observer 1 and observer 2 were 100–81.4% and 100–88.6%, respectively, for MR arthrograms in the neutral position; 100–52.9% and 100–62.9% for MR arthrograms in external rotation; and 100–95.7% and 81.8–98.6% for MR arthrograms in internal rotation. There was a fair agreement for MR arthrography in external rotation for detecting posterior synovial folds, while MR arthrograms in internal rotation and neutral position showed near-perfect and significant interobserver agreement.

Conclusion
The rotational positions of the humeral neck during MR arthrographic examination can influence the diagnostic specificity and sensitivity of axial MR arthrograms in detecting the posterior synovial fold.

Clinical relevance statement
The posterior synovial fold can mimic a posterior labral detachment. Therefore, its correct identification is crucial in order to avoid unnecessary surgical procedures.

Key Points

Movement of the shoulder may introduce variability in MR arthrography appearance.

Rotation of the humeral neck during MR arthrography can affect diagnoses in posterior synovial fold detection.

Given that posterior synovial folds can imitate posterior labral detachment, their correct identification is crucial to avoid unnecessary surgical procedures.
Root canal widths of mandibular molars in predicting the legal age threshold 18 years in a sample of juveniles and sub-adults of south-indian origin: an orthopantomographic study
Authors: Vedula Priyanka , Gannepalli Ashalata , Balla Sudheer Babu , Ch Gayathri , Bushra Anjum , Ayinampudi Bhargavi Krishna 
Published: July 2024

AbstractPursuing a proficient age estimation methodology introducing novel radiographic methods remains an ongoing and demanding aspect of forensic and medicolegal research. In 2017, Roberts GJ et al. (J Forensic Sci 62(2):351-4, 2017) described a new radiographic method, i.e., root canal width (RCW) patterns to assign a subject to above 18-year-age threshold. Since then, few researchers have investigated the validity of this radiographic method in other populations. The present study aimed to test the usefulness of these RCW patterns in predicting 18 years in a sample of South Indian juveniles and sub-adults aged between 16 and 23. Descriptive analysis revealed that pattern-A was initially observed at a minimum age of 16.08 and 16.22 years in males and females. Pattern-B at 16.31 years in males and 16.22 years in females, while pattern-C was initially recorded at 18.73 years in males and 19.01 years in females, respectively. In summary, if an individual, regardless of sex, exhibits a fully-formed (apex closed) mandibular first, second, and third molars and concurrently displays RCW-C, there is a strong likelihood that the person has exceeded the legally relevant age of 18 years. However, due to higher rate of technically unacceptable errors (adults wrongly identified as individuals below 18 years), reliance on this method alone should be restricted, and it is advisable to combine it with other methods.
A comparative study on the identification methods for calibration of the orthotropic yield surface and its effect on the sheet metal forming simulations
Authors: Sener Bora 
Published: July 2024

AbstractThe predictive capability of an anisotropic yield function highly relies upon the number of the model parameters and its calibration type. Conventional calibration of a plane stress anisotropic yield function considers material behavior in uniaxial and equi-biaxial stress states, whereas it violates shear and plane strain loading conditions. In this study, the direction of the plastic flow in both loading regions was corrected by including shear and plane strain constraint terms to the conventional calibration of the Yld2000 function, and its effect on the sheet metal forming simulations, namely cup drawing and hole expansion tests, was investigated. Two highly anisotropic sheet materials (AA2090-T3 and low-carbon steel) were selected for the investigation, and the anisotropy coefficients were determined. Stress anisotropy was accurately predicted by the conventional method, whereas any decrease in the prediction of the deformation anisotropy could not occur by the applying of the constrained methods. Significant increases in the predicted cup height and differences in the number of the ears were observed by shear constraint identification in the cup drawing. The maximum thinning location in the hole expansion test could be accurately predicted by plane strain constraint identification.
Validation of the European Portuguese Version of the Yale Pharyngeal Severity Rating Scale
Authors: Silva-Carvalho Isabel , Martins Adriana , Freitas Susana Vaz , Teixeira Laetitia , Meireles Luís , Pedroto Isabel 
Published: July 2024

AbstractThis study aimed to validate the Yale Pharyngeal Residue Severity Rating Scale’s European Portuguese version and investigate the impact of rater experience. The scale measures the severity of residue in the vallecula and pyriform sinus. Ninety Fiberoptic Endoscopic Evaluation of Swallowing images were selected after consensus and proposed to 13 raters who were asked to assess the severity of pharyngeal residue (PR) in each image in two moments with an interval of two weeks. The raters were divided by years of experience conducting the Fiberoptic Endoscopic Evaluation of Swallowing and in experience using severity scales for residues. Construct validity, inter-rater, and intra-rater reliability were assessed by kappa statistics. The original English scale was translated into European Portuguese using a forward–backward method for validation. The scale reliability was strong, with an elevated intra-rater internal consistency for vallecula (Cronbach’s alpha = 0.982) and pyriform sinus (Cronbach’s alpha = 0.922). Inter-rater reliability for raters was equally significant and high for vallecula (0.613 for first assessment and 0.604 for second assessment) and pyriform sinus (0.558 for first assessment and 0.509 for second assessment) or for raters with experience using Yale Pharyngeal Severity Rating Scale (vallecula with 0.832 for first assessment and 0.717 for second assessment and pyriform sinus with 0.856 for first assessment and 0.714 for second assessment).The European Portuguese version of the Yale Pharyngeal Severity Rating Scale is a valid, reliable instrument for scoring the location and severity of pharyngeal residue in the context of fiberoptic endoscopic evaluation of swallowing.
Multiple arbitrarily inflated negative binomial regression model and its application
Authors: Abusaif Ihab , Kuş Coşkun 
Published: July 2024

AbstractThis paper introduces a novel modification of the negative binomial distribution, which serves as a generalization encompassing both negative binomial and zero-inflated negative binomial distributions. This innovative distribution offers flexibility by accommodating an arbitrary number of inflation points at various locations. The paper explores key distributional properties associated with this modified distribution. Additionally, this study proposes several estimators designed to obtain estimates for the unknown parameters. Furthermore, the paper introduces a new count regression model that utilizes the modified distribution. To assess the performance of the proposed distribution and the count regression model, a comprehensive Monte Carlo simulation study is conducted. In the final stage of the paper, a real-world dataset is scrutinized to ascertain the superiority of the proposed model. This empirical analysis contributes to validating the practical applicability and effectiveness of the newly introduced distribution in comparison to existing models.
A co-evolutionary algorithm with adaptive penalty function for constrained optimization
Authors: de Melo Vinícius Veloso , Nascimento Alexandre Moreira , Iacca Giovanni 
Published: July 2024

AbstractSeveral constrained optimization problems have been adequately solved over the years thanks to the advances in the area of metaheuristics. Nevertheless, the question as to which search logic performs better on constrained optimization often arises. In this paper, we present Dual Search Optimization (DSO), a co-evolutionary algorithm that includes an adaptive penalty function to handle constrained problems. Compared to other self-adaptive metaheuristics, one of the main advantages of DSO is that it is able auto-construct its own perturbation logics, i.e., the ways solutions are modified to create new ones during the optimization process. This is accomplished by co-evolving the solutions (encoded as vectors of integer/real values) and perturbation strategies (encoded as Genetic Programming trees), in order to adapt the search to the problem. In addition to that, the adaptive penalty function allows the algorithm to handle constraints very effectively, yet with a minor additional algorithmic overhead. We compare DSO with several algorithms from the state-of-the-art on two sets of problems, namely: (1) seven well-known constrained engineering design problems and (2) the CEC 2017 benchmark for constrained optimization. Our results show that DSO can achieve state-of-the-art performances, being capable to automatically adjust its behavior to the problem at hand.