bluuebunny/crossref_metadata_2025_split huggingface dataset:
Computed Tomography Imaging Guided Microenvironment‐Responsive Ir@WO3−x Dual‐Catalytic Nanoreactor for Selective Radiosensitization
Authors: Song Jiayu , Feng Yue , Yan Jiazhuo , Wang Ying , Yan Weixiao , Yang Nan , Wu Tusheng , Liu Sijia , Wang Yuan , Zheng Nannan , He Liangcan , Zhang Yunyan 
Published: August 2024

AbstractRadiotherapy (RT) is often administered, either alone or in combination with other therapies, for most malignancies. However, the degree of tumor oxygenation, damage to adjacent healthy tissues, and inaccurate guidance remain issues that result in discontinuation or failure of RT. Here, a multifunctional therapeutic platform based on Ir@WO3−x is developed which simultaneously addresses these critical issues above for precision radiosensitization. Ir@WO3−x nanoreactors exhibit strong absorption of X‐ray, acting as radiosensitizers. Moreover, ultrasmall Ir enzyme‐mimic nanocrystals (NCs) are decorated onto the surface of the nanoreactor, where NCs have catalyst‐like activity and are sensitive to H2O2 in the tumor microenvironment (TME) under near infrared‐II (NIR‐II) light stimulation. They efficiently catalyze the conversion of H2O2 to O2, thereby ameliorating hypoxia, inhibiting the expression of HIF‐1α, and enhancing RT‐induced DNA damage in cancerous tissue, further improving the efficiency of RT. Additionally, in response to high H2O2 levels in TME, the Ir@WO3−x nanoreactor also exerts peroxidase‐like activity, boosting exogenous ROS, which increases oxidative damage and enhances ROS‐dependent death signaling. Furthermore, Ir@WO3−x can serve as a high‐quality computed tomography contrast agent due to its high X‐ray attenuation coefficient and generation of pronounced tumor‐tissue contrast. This report highlights the potential of advanced health materials to enhance precision therapeutic modalities.
Ubiquitin‐Specific Protease 22 Plays a Key Role in Increasing Extracellular Vesicle Secretion and Regulating Cell Motility of Lung Adenocarcinoma
Authors: Zhen Fang , Sun Yue , Wang Hongyi , Liu Wei , Liang Xiao , Wang Yaru , Wang Qi , Hu Jing 
Published: August 2024

AbstractTumor‐derived extracellular vesicles (EVs) are potential biomarkers for tumors, but their reliable molecular targets have not been identified. The previous study confirms that ubiquitin‐specific protease 22 (USP22) promotes lung adenocarcinoma (LUAD) metastasis in vivo and in vitro. Moreover, USP22 regulates endocytosis of tumor cells and localizes to late endosomes. However, the role of USP22 in the secretion of tumor cell‐derived EVs remains unknown. In this study, it demonstrates that USP22 increases the secretion of tumor cell‐derived EVs and accelerates their migration and invasion, invadopodia formation, and angiogenesis via EV transfer. USP22 enhances EV secretion by upregulating myosin IB (MYO1B). This study further discovers that USP22 activated the SRC signaling pathway by upregulating the molecule KDEL endoplasmic reticulum protein retention receptor 1 (KDELR1), thereby contributing to LUAD cell progression. The study provides novel insights into the role of USP22 in EV secretion and cell motility regulation in LUAD.
Photoinduced Single Electron Reduction of the 4‐O‐5 Linkage in Lignin Models for C‐P Coupling Catalyzed by Bifunctional N‐Heterocyclic Carbenes
Authors: Liu Qiang , Ren Ying‐Zheng , Zhang Bei‐Bei , Tang Wen‐Xin , Wang Zhi‐Xiang , He Lin , Chen Xiang‐Yu 
Published: August 2024

AbstractCatalytic activation of Caryl‐O bonds is considered as a powerful strategy for the production of aromatics from lignin. However, due to the high reduction potentials of diaryl ether 4‐O‐5 linkage models, their single electron reduction remains a daunting challenge. This study presents the blue light‐induced bifunctional N‐heterocyclic carbene (NHC)‐catalyzed one‐electron reduction of diaryl ether 4‐O‐5 linkage models for the synthesis of trivalent phosphines. The H‐bond between the newly devised bifunctional NHC and diaryl ethers is responsible for the success of the single electron transfer. Furthermore, this approach demonstrates selective one‐electron reduction of unsymmetric diaryl ethers, oligomeric phenylene oxide, and lignin model.
Super‐Durable, Tough Shape‐Memory Polymeric Materials Woven from Interlocking Rigid‐Flexible Chains
Authors: Xu Jing , Shao Mingchao , Chen Tianze , Li Song , Zhang Yaoming , Yang Zenghui , Zhang Nan , Zhang Xinrui , Wang Qihua , Wang Tingmei 
Published: August 2024

AbstractDeveloping advanced engineering polymers that combine high strength and toughness represents not only a necessary path to excellence but also a major technical challenge. Here for the first time a rigid‐flexible interlocking polymer (RFIP) is reported featuring remarkable mechanical properties, consisting of flexible polyurethane (PU) and rigid polyimide (PI) chains cleverly woven together around the copper(I) ions center. By rationally weaving PI, PU chains, and copper(I) ions, RFIP exhibits ultra‐high strength (twice that of unwoven polymers, 91.4 ± 3.3 MPa), toughness (448.0 ± 14.2 MJ m−3), fatigue resistance (recoverable after 10 000 cyclic stretches), and shape memory properties. Simulation results and characterization analysis together support the correlation between microstructure and macroscopic features, confirming the greater cohesive energy of the interwoven network and providing insights into strengthening toughening mechanisms. The essence of weaving on the atomic and molecular levels is fused to obtain brilliant and valuable mechanical properties, opening new perspectives in designing robust and stable polymers.
Axially‐Polarized Excitonic Series and Anisotropic van der Waals Stacked Heterojunction in a Quasi‐1D Layered Transition‐Metal Trichalcogenide
Authors: Rosyadi Adzilah Shahna , Lin Ying‐Xuan , Peng Yu‐Hung , Ho Ching‐Hwa 
Published: August 2024

AbstractAnisotropic optical 2D materials are crucial for achieving multiple‐quanta functions within quantum materials, which enables the fabrication of axially polarized electronic and optoelectronic devices. In this work, multiple excitonic emissions owning polarization‐sensitive orientations are clearly detected in a multilayered quasi‐1D ZrS3 nanoribbon with respect to the nanostripe edge. Four excitons denoted as AS1, AS2, AS, and A2 with E ⊥ b polarized direction and one prominent A1 exciton with E || b polarized emission are simultaneously detected in the polarized micro‐photoluminescence (µPL) measurement of 1.9–2.2 eV at 10 K. In contrast to light emission, polarized micro‐thermoreflectance (µTR) measurements are performed to identify the polarization dependence and verify the excitons in the multilayered ZrS3 nanoribbon from the perspective of light absorption. At 10 K, a prominent and broadened peak on the lower‐energy side, containing an indirect resonant emission (DI) observed by µPL and an indirect defect‐bound exciton peak (AInd) observed by both µPL and µTR, is simultaneously detected, confirming the existence of a quasi‐direct band edge in ZrS3. A van der Waals stacked p‐GaSe/n‐ZrS3 heterojunction solar cell is fabricated, which demonstrates a maximum axially‐polarized conversion efficiency up to 0.412% as the E || b polarized light incident onto the device.
Construction of Sulfone‐Based Polymer Electrolyte Interface Enables the High Cyclic Stability of 4.6 V LiCoO2 Cathode by In Situ Polymerization
Authors: Huang Yuli , Cao Bowei , Xu Xilin , Li Xiaoyun , Zhou Kun , Geng Zhen , Li Quan , Yu Xiqian , Li Hong 
Published: August 2024

AbstractLithium cobalt oxide (LiCoO2) is considered an indispensable cathode material in the realm of consumer electronic batteries due to its high volumetric energy density. However, at a charging cut‐off voltage as high as 4.6 V, significant interfacial side reactions between LiCoO2 and the electrolyte occur, which adversely impact the battery's cycle performance. The surface‐related issues of LiCoO2 at high charge voltages not only constrain its utilization in conventional lithium‐ion batteries with liquid electrolytes but also limit its application in solid‐state batteries. Although traditional coating methods using inert inorganic compounds can partially alleviate this issue, their point‐like coatings fail to completely prevent the surface of LiCoO2 from direct contact with the electrolyte. The exploration of novel surface protection strategies for LiCoO2 remains imperative to address the associated challenges. Herein, introducing a sulfone‐based polymer electrolyte interface is proposed on the surface of LiCoO2 using methyl vinyl sulfone (MVS) through in situ polymerization. Remarkably, LiCoO2 with sulfone‐based polymer electrolyte interface exhibits a capacity retention rate of 83% after 500 cycles when employing a carbonate electrolyte without additives at a charge cut‐off voltage of 4.6 V. Furthermore, the LiCoO2 and polymer electrolyte interface exhibits exceptional cycle stability when paired with polyether solid electrolytes that do not possess high voltage tolerance. Moreover, the incorporation of a polymer electrolyte interface not only enhances the cycle stability of LiCoO2 but also improves its thermal stability. This work presents novel research perspectives for exploring high‐voltage stable LiCoO2.
Rotating cylinder electrode in reactive CO2 capture: Identifying active C species via transport, VLE models and kinetics
Authors: Banerjee Avishek , Yue Chudi , Choi Jounghwan , Morales‐Guio Carlos G. 
Published: August 2024

AbstractThis article explores technical challenges and potential methodologies for understanding electrochemical Reactive CO Capture (RCC) mechanisms. RCC offers potential energy cost advantages by directly converting captured CO into fuels and chemicals, unlike traditional carbon capture and utilization (CCU) processes that require sequential capture, concentration, and compression. However, direct conversion of captured CO introduces complexity due to additional equilibrium buffer reactions, making it challenging to identify active species for reduction in electrochemical studies. This article discusses methods to integrate transport, thermodynamics, and kinetics concepts to identify active carbon sources in RCC. Vapor‐Liquid Equilibrium (VLE) and transport models are validated against experimental results obtained in a gastight rotating cylinder electrode reactor and are shown as useful tools for studying RCC in heterogeneous electrocatalysts across different capture agents, solvents, and temperatures. This article establishes an experimental framework for advancing research in electrochemical RCC.
Presentation of ichthyosis after substrate reduction therapy in Gaucher type 1
Authors: Herbster Jack , Prada Carlos E. , Rasmussen Carly A. , Quadri Allegra , Kuritza Victoria , Viglione Michael , Hoyer Sheryl 
Published: August 2024

AbstractWe describe a case in which a type 1 Gaucher patient developed ichthyosis weeks after starting substrate reduction therapy (SRT) with eliglustat. There are no reports of ichthyosis in the literature in enzyme replacement or SRT for Gaucher disease. Ichthyosis is seen with type 2 and 3 Gaucher disease, but not type 1. This raises the question: Why would a patient develop ichthyosis after starting SRT?
Co‐prevalence of chronic rhinosinusitis and inflammatory bowel disease: A large aggregated electronic health record study
Authors: Dhamija Ravi , Ding Peng , Das Nikita , Shah Varunil N. , Kaelber David C. , Chaaban Mohamad R. 
Published: August 2024

Key points
IBD patients have a 4.04‐fold elevated likelihood of having CRS compared to non‐IBD patients.
CRS patients have a 4.23‐fold elevated likelihood of having IBD compared to non‐CRS patients.
The risk of CRS development after IBD is five times higher than IBD development after CRS.
Prediction of Cognitive Heterogeneity in Parkinson's Disease: A 4‐Year Longitudinal Study Using Clinical, Neuroimaging, Biological and Electrophysiological Biomarkers
Authors: Puig‐Davi Arnau , Martinez‐Horta Saul , Pérez‐Carasol Laura , Horta‐Barba Andrea , Ruiz‐Barrio Iñigo , Aracil‐Bolaños Ignacio , Pérez‐González Rocío , Rivas‐Asensio Elisa , Sampedro Frederic , Campolongo Antonia , Pagonabarraga Javier , Kulisevsky Jaime 
Published: August 2024

ObjectiveCognitive impairment in Parkinson's disease (PD) can show a very heterogeneous trajectory among patients. Here, we explored the mechanisms involved in the expression and prediction of different cognitive phenotypes over 4 years.MethodsIn 2 independent cohorts (total n = 475), we performed a cluster analysis to identify trajectories of cognitive progression. Baseline and longitudinal level II neuropsychological assessments were conducted, and baseline structural magnetic resonance imaging, resting electroencephalogram and neurofilament light chain plasma quantification were carried out. Linear mixed‐effects models were used to study longitudinal changes. Risk of mild cognitive impairment and dementia were estimated using multivariable hazard regression. Spectral power density from the electroencephalogram at baseline and source localization were computed.ResultsTwo cognitive trajectories were identified. Cluster 1 presented stability (PD‐Stable) over time, whereas cluster 2 showed progressive cognitive decline (PD‐Progressors). The PD‐Progressors group showed an increased risk for evolving to PD mild cognitive impairment (HR 2.09; 95% CI 1.11–3.95) and a marked risk for dementia (HR 4.87; 95% CI 1.34–17.76), associated with progressive worsening in posterior‐cortical‐dependent cognitive processes. Both clusters showed equivalent clinical and sociodemographic characteristics, structural magnetic resonance imaging, and neurofilament light chain levels at baseline. Conversely, the PD‐Progressors group showed a fronto‐temporo‐occipital and parietal slow‐wave power density increase, that was in turn related to worsening at 2 and 4 years of follow‐up in different cognitive measures.InterpretationIn the absence of differences in baseline cognitive function and typical markers of neurodegeneration, the further development of an aggressive cognitive decline in PD is associated with increased slow‐wave power density and with a different profile of worsening in several posterior‐cortical‐dependent tasks. ANN NEUROL 2024;96:981–993
An Approach to Successful Development of Clinician–Scientists in Neurology: The NINDS R25 Experience
Authors: Josephson S. Andrew , Tennekoon Michael S. , Carmichael S. Thomas , Cash Sydney S. , Detre John A. , Hillis Argye E. , Pennell Page B. , Pomeroy Scott L. , Richerson George B. , Sansing Lauren H. , Korn Stephen J. 
Published: August 2024

ObjectiveTraining clinician–scientists is a primary objective of many academic neurology departments, as these individuals are uniquely positioned to perform insightful clinical or laboratory‐based research informed both by clinical knowledge and their own experiences caring for patients. Despite its importance, training clinician–scientists has perhaps never been so challenging. The National Institute of Neurologic Disorders and Stroke (NINDS) R25 program was designed in an attempt to support these individuals, decrease the time needed to obtain National Institutes of Health K awards, and to help educate a cohort of trainees preparing for a career in academic neurology. We endeavored to describe the structure and features of the program while examining its outcomes.MethodsR25 outcome data from 2009 to 2024 were reviewed. Statistical comparisons were made using 2‐sided Mann–Whitney U testing.ResultsA total of 67% of adult neurologists who received an R25 had a successful application for a National Institutes of Health K award compared with 45% of adult neurologists who had not received R25 support (p < 0.0001). Among child neurologists, 73% who applied went on to receive K funding after R25 support, compared with 45% who had not been part of the R25 program (p < 0.001). The average time between completion of residency and obtaining a K award for R25 participants was decreased by 26 months among those with an MD/PhD degree, and 32 months for those with an MD degree compared with non‐R25 individuals.InterpretationThe R25 program has been successful in achieving its training goals, but stands as only one component of support for aspiring clinician–scientists. Investments and commitments made by academic neurology departments are key to supporting this success. ANN NEUROL 2024;96:625–632
Signal Amplification by Reversible Exchange and its Translation to Hyperpolarized Magnetic Resonance Imaging in Biomedicine
Authors: Schmidt Andreas B. , Chekmenev Eduard Y. , de Maissin Henri , Groß Philipp R. , Petersen Stefan , Nagel Luca , Schilling Franz , Schwartz Ilai , Reinheckel Thomas , Hövener Jan‐Bernd , Knecht Stephan 
Published: August 2024

AbstractHyperpolarized magnetic resonance imaging (HP‐MRI) has emerged as a powerful tool in molecular imaging, providing in vivo, real‐time insights into metabolic pathways without ionizing radiation. Signal Amplification by Reversible Exchange (SABRE) represents a promising hyperpolarization technique, leveraging parahydrogen to enhance MRI signals. In this concept, we delineate the evolution of SABRE and landmark papers that have enabled us recently to produce biocompatible and low‐cost hyperpolarized pyruvate within minutes for in vivo metabolic imaging, showcasing SABRE′s potential for preclinical and near‐future clinical settings. Looking ahead, with ongoing efforts focused on optimizing polarizer technology and expanding applications beyond pyruvate, we envision SABRE as a key player in the research and application of HP‐MRI due to its simplicity and throughput.
Enhancement of flame retardancy in ceramic polymer composite materials with ammonium polyphosphate/melamine cyanurate
Authors: Zhou Shitao , Xu Lang , Sun Qing , Zhang Jian , Sheng Jiawei 
Published: August 2024

AbstractTo enhance the flame‐retardant characteristics of ceramifiable polyethylene (PE) composites, a composite flame retardant comprising ammonium polyphosphate (APP) and melamine cyanurate (MCA) was integrated. This addition markedly bolstered their flame‐retardant attributes. A meticulous exploration was conducted to ascertain the impacts of APP and MCA on the ceramifiable PE composites' visible morphology, mechanical robustness, and dimensional constancy, and to study the phase transition and microstructure deformation during sintering. Findings underscored that the amalgamation of APP/MCA markedly enhanced the flame resistance of these ceramifiable composites, registering a limiting oxygen index of 25.6% and achieving the vertical burning test (UL‐94) rating of V‐0. The collaborative flame‐retardant action of APP/MCA significantly enhanced the flame resistance of the PE composites while effectively mitigating the composite's propensity to drip. Upon detailed phase analysis, a eutectic reaction was observed between APP and wollastonite fiber, culminating in the genesis of a novel crystalline phase, calcium pyrophosphate (Ca2P2O7). When subjected to elevated temperatures, glass–ceramics manifest with both crystalline and vitreous phases. The proportion of the vitreous phase plays a pivotal role in influencing the ceramic's overall performance.
Corrosion protective properties on 2024‐T3 of chitosan‐modified montmorillonite epoxy coatings based on Ce3+ loading
Authors: Li Gang , Li Yayun , Lin Chuanxi , Peng Hao , Xue Yunsheng , Qin Wenfeng , Zhao Xin , Zhou Bin 
Published: August 2024

Abstract2024 aluminum alloy has high strength, processing performance, and good damage tolerance performance, but it is prone to intergranular corrosion and pitting. Therefore, the development of corrosion protective coatings is essential for the aluminum alloy. In this paper, cerium ion (Ce3+) was doped into chitosan‐modified montmorillonite (Ce‐CS‐MMT) by ion exchange method, and the corrosion protective performance of Ce‐CS‐MMT epoxy coating (Ce‐CS‐MMT/EP) was investigated. The electrochemical analysis of aluminum alloy in cerium‐containing solution showed the corrosion inhibition efficiency reached 95.52%. The result indicates the corrosion inhibition effect of cerium‐containing solution was better than pure NaCl solution and MMT solution. The corrosion study of the coating illustrates that the protection rate of Ce‐CS‐MMT/EP reached 95.82%, which was higher than that 91.83% of Ce‐MMT/EP. The result indicates the resistance of charge transfer was greater and the better shielding effect for electrolyte corrosion ions than MMT and Ce‐MMT epoxy coatings, and the corrosion protective performance was excellent.
Advanced Modeling of Electro‐Optic Sampling: Nonlinear Vectoral‐Field Solutions to Maxwell's Equations
Authors: Carnio B. N. , Moutanabbir O. , Elezzabi A. Y. 
Published: August 2024

AbstractA comprehensive modeling approach for elucidating the intricacies of electro‐optic (EO) sampling is presented, which fully encapsulates the EO sampling process by accounting for all linear and second‐order nonlinear optical effects. The developed approach implements a multi‐step procedure, involving a vectorial‐field modeling of the second‐order nonlinear interactions occurring within the EO crystal, followed by a theoretical evaluation of the subsequent optical EO sampling components. To assess the efficacy of the approach, it is used for the sampling of terahertz electric fields (<1–>60 THz) within the bulk crystals of ZnTe and LiNbO3, as well as a ZnTe‐based waveguide. Nonetheless, this versatile method enables the investigation of EO sampling within any crystal incorporated within any geometry. This model provides a powerful tool for the in‐depth exploration of EO sampling, paving the way for advancements in various applications.
Utility of dynamic contrast enhancement for clinically significant prostate cancer detection
Authors: Li Eric V. , Kumar Sai K. , Aguiar Jonathan A. , Siddiqui Mohammad R. , Neill Clayton , Sun Zequn , Schaeffer Edward M. , Jawahar Anugayathri , Ross Ashley E. , Patel Hiten D. 
Published: August 2024

AbstractObjectiveThis study aimed to evaluate the association of dynamic contrast enhancement (DCE) with clinically significant prostate cancer (csPCa, Gleason Grade Group ≥2) and compare biparametric magnetic resonance imaging (bpMRI) and multiparametric MRI (mpMRI) nomograms.Subjects/patients and methodsWe identified a retrospective cohort of biopsy naïve patients who underwent pre‐biopsy MRI separated by individual MRI series from 2018 to 2022. csPCa detection rates were calculated for patients with peripheral zone (PZ) lesions scored 3–5 on diffusion weighted imaging (DWI) with available DCE (annotated as − or +). bpMRI Prostate Imaging Reporting and Data System (PIRADS) (3 = 3−, 3+; 4 = 4−, 4+; 5 = 5−, 5+) and mpMRI PIRADS (3 = 3−; 4 = 3+, 4−, 4+; 5 = 5−, 5+) approaches were compared in multivariable logistic regression models. Nomograms for detection of csPCa and ≥GG3 PCa incorporating all biopsy naïve patients who underwent prostate MRI were generated based on available serum biomarkers [PHI, % free prostate‐specific antigen (PSA), or total PSA] and validated with an independent cohort.ResultsPatients (n = 1010) with highest PIRADS lesion in PZ were included in initial analysis with 127 (12.6%) classified as PIRADS 3+ (PIRADS 3 on bpMRI but PIRADS 4 on mpMRI). On multivariable analysis, PIRADS 3+ lesions were associated with higher csPCa rates compared to PIRADS 3− (3+ vs. 3−: OR 1.86, p = 0.024), but lower csPCa rates compared to PIRADS DWI 4 lesions (4 vs. 3+: OR 2.39, p < 0.001). csPCa rates were 19% (3−), 31% (3+), 41.5% (4−), 65.9% (4+), 62.5% (5−), and 92.3% (5+). bpMRI nomograms were non‐inferior to mpMRI nomograms in the development (n = 1410) and independent validation (n = 353) cohorts. Risk calculators available at: https://rossnm1.shinyapps.io/MynMRIskCalculator/.ConclusionWhile DCE positivity by itself was associated with csPCa among patients with highest PIRADS lesions in the PZ, nomogram comparisons suggest that there is no significant difference in performance of bpMRI and mpMRI. bpMRI may be considered as an alternative to mpMRI for prostate cancer evaluation in many situations.