bluuebunny/crossref_metadata_2025_split huggingface dataset:
Metabolomic comparison of postprandial distress syndrome patients with and without duodenal eosinophilia
Authors: Dalal Stuti , Ajit Deepa , Friesen Chance S. , Shakhnovich Valentina , Singh Meenal , Colombo Jennifer M. , Schurman Jennifer V. , Friesen Craig A. 
Published: August 2024

AbstractObjectiveIn functional dyspepsia patients, duodenal mucosal eosinophilia has been associated with early satiety but is not present in all patients suggesting varied pathways to symptom generation. The objective of the current study was to explore metabolic differences comparing those with duodenal mucosal eosinophilia to those without eosinophilia.MethodsThis study was conducted utilizing an existing biorepository. Patients had plasma samples obtained at the time of endoscopy. All had undergone endoscopy for dyspepsia and reported early satiety. Two groups were identified including those with peak duodenal mucosal eosinophil densities above 30/high power field (N = 28) and those below 30 (N = 16). The fasting plasma samples were analyzed by liquid chromatography/high‐resolution mass spectrometry. Significant differences between groups were determined.ResultsThe eosinophilia group demonstrated significant elevations in several gamma‐glutamyl amino acids. The eosinophilia group had elevations of metabolites associated with oxidative stress including glutathione metabolites (cysteinlyglycine and cys‐gly oxidized), and metabolites related to nitric oxide synthesis (arginine, citrulline, ornithine, and dimethylarginine). Eosinophilia was also associated with alterations in lipid metabolism including several long‐chain acylcarnitine conjugated fatty acids. Carnitine levels were lower in the eosinophilia group. Lastly, vanillymandelate, a derivative of norepinephrine and epinephrine was elevated in the eosinophilia group.ConclusionsIn patients with dyspepsia and early satiety, duodenal mucosal eosinophilia is associated with metabolites levels which are consistent with increased oxidative stress and alterations in lipid metabolism. Eosinophilia was also associated with lower carnitine levels. These alterations may contribute to pathophysiology and represent therapeutic targets.
The Ansoff archive: Revisiting Ansoff's legacy and the holistic approach to strategic management
Authors: Puyt Richard W. , Antoniou Peter H. , Caputo Andrea 
Published: August 2024

AbstractThis paper explores the profound influence and legacy of H. Igor Ansoff in the field of strategic management. Ansoff, a Russian‐American mathematician known as the father of strategic management, introduced groundbreaking concepts such as the Ansoff matrix and long‐range planning. The Ansoff Institute's recent initiative to establish the Ansoff Archives at the University of Twente underscores his enduring impact on strategic management research. This archive aims to preserve his intellectual contributions and support future scholarship. The paper reviews Ansoff's seminal works, including his influential publication Corporate Strategy (1965) and discusses his holistic approach to strategic change, which remains relevant in today's dynamic organizational environments. By commemorating Ansoff's contributions, the paper highlights the importance of his strategic frameworks in guiding contemporary issue management amidst unprecedented levels of uncertainty and change.
Development of cellulose‐based biosorbents from the residue of the peach palm agribusiness and simulation of industrial scale‐up for copper removal from Brazilian spirit
Authors: Arantes Matheus Samponi Tucunduva , Miranda Thalia Marchinhaki Pedro , Magalhães Washington Luiz Esteves , Helm Cristiane Vieira , da Silva Vítor Renan 
Published: August 2024

AbstractBACKGROUNDCachaça (Brazilian spirit) is an alcoholic beverage of cultural and economic importance in Brazil. Its artisanal production is usually conducted in copper alembics, which results in contamination. The development of effective biosorbents from cheap matrices is an alternative to minimize both solid waste generation and copper levels in cachaça. The present work evaluates the obtention of nanocellulose‐based materials from the major residue generated during the processing of palm heart from the Brazilian peach palm, through different processing techniques. Materials were characterized by physicochemical composition and their sorbent capacities for copper removal from aqueous solutions, and a simulation was conducted to evaluate potential application in the adequacy of cachaça to meet Brazilian legislation requirements.RESULTSThe different processing methods resulted in different cellulose concentrations, with the highest concentration in the bleached material (B3, 694 g kg−1 of cellulose), and different specific surface areas (1.02–12.4 m2 g−1). Copper adsorption onto nanocellulose obtained from peach palm external sheath is fast, with a predominance of a chemisorption mechanism. Isotherms were best represented by Langmuir's model, suggesting a monolayer adsorption. Simulations indicate that B3 is a suitable material for the removal of copper from cachaça, and small amounts of biosorbent (733.5 g) are required for the reduction of copper concentrations (10 to 3 mg L−1) in 1000 L of cachaça.CONCLUSIONThis study demonstrated that the obtention of biosorbents from peach palm solid residues is promising and this nanocellulose‐based material can be used for copper removal from contaminated cachaça. © 2024 Society of Chemical Industry.
Preparation and characterization of microcrystalline cellulose from rice bran
Authors: Liu Yanlan , Ran Jingfeng , Xu Ziyang , Cheng Hao , Lin Benping , Deng Tianran , Yi Cuiping 
Published: August 2024

AbstractBACKGROUNDRice bran, a by‐product of rice processing, has not been fully utilized except for the small amount used for raising animals. The raw material source requirements of microcrystalline cellulose are becoming increasingly extensive. However, the characteristics of preparing microcrystalline cellulose from rice bran have not been reported, which limits the application of rice bran.RESULTSMicrocrystalline cellulose was obtained from rice bran by alkali treatment, delignification, bleaching and acid hydrolysis. The morphology, particle size distribution, degree of polymerization, crystallinity, and thermal stability of rice bran microcrystalline cellulose were analyzed. The chemical compositions, scanning electron microscopy and Fourier‐transform infrared analysis for rice bran microcrystalline cellulose showed that the lignin and hemicellulose were successfully removed from the rice bran fiber matrix. The morphology of rice bran microcrystalline cellulose was shown to be of a short rod‐shaped porous structure with an average diameter of 65.3 μm. The polymerization degree of rice bran microcrystalline cellulose was 150. The X‐ray diffraction pattern of rice bran microcrystalline cellulose showed the characteristic peak of natural cellulose (type I), and its crystallization index was 71%. The rice bran microcrystalline cellulose may be used in biological composites with temperatures between 150 °C and 250 °C.CONCLUSIONThese results suggest the feasibility of using rice bran as a low‐price source of microcrystalline cellulose. © 2024 Society of Chemical Industry.
Analysis of nitrogen‐containing rocket fuel transformation products in loamy soil by thermal desorption gas chromatography‐tandem mass spectrometry
Authors: Popov Mark S. , Kosyakov Dmitry S. , Ul'yanovskii Nikolay V. 
Published: August 2024

Unsymmetrical dimethylhydrazine (UDMH) based rocket fuel, when released into the soil, undergoes oxidative transformations to form a variety of toxic nitrogen‐containing products (TPs). Loamy soils containing aluminosilicates (clay) are capable of strong binding and retention of UDMH TPs due to a combination of polar sorption and cation‐exchange properties, posing challenges for their extraction and quantification. To overcome this problem, the present study proposes direct thermal desorption (TD) of analytes from loam facilitated by the addition of modifiers competing with UDMH TPs for sorption centers and ensuring their conversion into molecular form. Among tested additives, the mixture of potassium chloride and hydroxide demonstrated the best performance and provided recoveries of the most UDMH TPs exceeding 70% under optimized TD conditions (200°C, 30 min). The online combination of TD with gas chromatography‐tandem mass spectrometry allowed for the development of a method for the determination of 15 UDMH TPs in loamy soils with limits of detection in the range of 0.2–15 µg/kg. The use of matrix‐matched calibration and deuterated internal standards ensured high accuracy (80%–100%) and precision (relative standard deviation < 18%) of the analysis. The developed method was validated and successfully tested in the analyses of real loamy soil samples polluted with rocket fuel.
How do tourists perceive churches as tourism destinations? A text mining approach through online reviews
Authors: Sun Shaolong , Wang Lintao , Zhao Erlong , Wang Shouyang 
Published: August 2024

AbstractChurch tourism has gained popularity due to the historical, artistic, and religious significance of churches, contributing significantly to the social and economic sectors. The destination image of churches plays a crucial role in tourism marketing. However, existing literature predominantly relies on traditional methods to study tourists' perception of churches as tourism destinations, with limited analysis of user‐generated content (UGC) like online reviews. This study aims to fill this gap by analyzing the online reviews of 10 renowned European churches posted on TripAdvisor using text mining techniques. Findings reveal that tourists mainly focus on overall description, visiting experience, architectural design, and surrounding environment of the church, with specific areas of interest for certain churches. The research findings can assist church administrators in formulating sustainable tourism strategies and promoting the development of the church tourism.
How Does Educational Travel Promote Lifelong Learning?
Authors: Chau Salott , Ren Lianping 
Published: August 2024

ABSTRACTTravel contributes to learning and learning can make travel more meaningful. However, the extant literature that exemplifies how educational travel influences an individual's attitude toward learning is limited. Based on social constructivism and self‐determination theory, and utilizing an online survey (N = 321), this study examines how university students' educational travel experiences lead to changes in academic motivation and wellbeing, which may enhance attitudes toward lifelong learning. The conceptual model of lifelong learning in relation to educational travel, academic motivation, and wellbeing is developed and confirmed. The full mediation effect of academic motivation and wellbeing is established. The survey results reveal a positive relationship between educational travel experience and learners' attitude change in lifelong learning. The study highlights the role of educational travel experience in promoting attitudinal changes toward lifelong learning, which provides implications to both travel companies and educational institutes for design and development of educational travel activities and programs.
Transparent Ho3+/Tm3+/Er3+/Yb3+ Codoped Nano‐Glass‐Ceramics for Upconversion Head‐Up Display
Authors: You Fengluan , Zheng Song , Pang Tao , Zeng Lingwei , Lei Lei , Lin Shisheng , Zhang Jinzhe , Shen Tongjie , Huang Feng , Chen Daqin 
Published: August 2024

AbstractThe commonly used automotive head‐up display (HUD) technology is confronted with the problems of poor stability in organic resin counterpart and the unsatisfactory display effect of projection lighting source. To solve these issues, developing state‐of‐the‐art materials and designing new HUD schemes with a wide color gamut is of necessity. Herein, a series of pure red/green/blue (R/G/B) upconverting (UC) nano‐glass‐ceramics (GCs) containing lanthanide‐doped NaLuF4 nanocrystals (NCs) are synthesized in a cost‐effective, environment‐friendly, and scalable manner, simultaneously achieving high crystallinity (≈45.44%) and high transparency (>80%). Yb3+ is chosen as the sensitizer to Tm3+ (blue UC)/Ho3+ (green UC), due to its large absorption cross section from ground state 2F7/2 to excited state 2F5/2; meanwhile Er3+, Tm3+ co‐doped into NCs can obtain pure red UC emission via promoting the population of Er3+ red‐emitting 4F9/2 state. Consequently, the as‐prepared materials exhibit high R/G/B color purity of > 80% owing to the energy transfer between different lanthanide ions (Yb3+, Tm3+, Ho3+, and Er3+) upon 980 nm near‐infrared (NIR) laser excitation, and possess superior thermal reversibility/water resistivity. Remarkably, two unprecedented HUD prototypes are constructed to demonstrate the application feasibility of developed pure R/G/B UC GCs.
Green or non‐green product: A game‐theoretic framework to make optimal decision in a two‐level supply chain
Authors: Santra Gayapada , Maiti Tarun , Giri Bibhas Chandra 
Published: August 2024

AbstractThis paper aims to discuss the decisions made by the retailer and manufacturer in a supply chain about pricing, green level, and quality of a product. The centralized model and the manufacturer‐led Stackelberg gaming model are developed for a conventional product and its environmentally friendly version. The two green models are subsequently compared with two non‐green models. Finally, a comprehensive variation of the model is considered, accounting for both green and non‐green products. The green‐only supply chain generates higher profit than the one that uses non‐green products. A revenue‐sharing contract is also employed to coordinate the supply chain.
Surgical management and histopathological patterns of periampullary cancers in Sudanese patients: A single‐center prospective study
Authors: Adam Ismail Mohammad , Abdelrahim Elfatih Yousif , Doush Wael Mohialddin Ahmed 
Published: August 2024

AbstractBackgroundHistopathological patterns of periampullary cancers (PAC) provide valuable information for clinicians in the selection of effective postoperative therapies and serve as a prognostic marker for patients. Therefore, this study was conducted to determine the surgical management and histopathological patterns of PAC necessary to achieve excellent surgical outcomes.MethodsThis prospective study was conducted from October 2021 to September 2023 at Ibn Sina Specialized Hospital, Khartoum, Sudan. Eighty patients diagnosed with resectable PAC were enrolled.ResultsPAC was more prevalent in male patients (52.5%), with a male: female ratio of 1.1:1.0. The peak incidence occurred between 46 and 60 years, representing 38.75% of patients. The most significant reported comorbidity was cigarette smoking (36.25% of patients). Scleral icterus was found in 47.5% of patients. Pancreatic head cancer was found in 55% of patients. Histopathological analysis revealed adenocarcinoma in 82.5% of patients. R0 resection (tumor‐free margins) was the most common resection category (87.5% of patients). Lymphovascular invasion was detected in 37.5% of patients. Malignant lymph node involvement (1–3 nodes) was found 47.5% of patients. Perineural invasion was found in 55%. Finally, the most common histopathological differentiation of PAC was well‐differentiated (Grade I) in 67.5% of patients. The mortality rate was 0%.ConclusionsUpdated knowledge regarding the management modalities of PAC is a prerequisite for accurate histopathological assessment and good surgical outcomes. Furthermore, histopathological analysis helps clinicians to select effective postoperative therapies for greater improvement in survival outcomes.
Effect of annealing treatment on impact toughness and crystallization behaviors of polypropylene/ethylene vinyl acetate copolymer/layered double hydroxide composites
Authors: Guo Xincheng , Lian Honglin , Qin Jun , Guo Jianbing , Chen Xiaolang , Chu Longsheng 
Published: August 2024

AbstractThis research endeavors to explore the potential of annealing treatment as a viable strategy to optimize the utilization of polypropylene (PP) composites, while preserving their exceptional properties. By incorporating ethylene vinyl acetate (EVA) copolymer and layered double hydroxide (LDH) into PP, this work meticulously analyzes the changes in crystallization behaviors and impact properties under varying annealing conditions. Impact strength is systematically assessed by a digital pendulum impact tester, whereas the crystalline structure is analyzed through polarized light optical microscopy (POM), differential scanning calorimetry (DSC), and x‐ray diffraction (XRD). The notch impact test exhibits a gradual increase in impact strength from 100 to 130°C, followed by a decline at 140°C. The XRD and DSC results elucidate subtle β‐crystal diffraction peaks for PP/EVA and PP/EVA/LDH composites, attributed to the transformative effect of EVA and LDH on PP crystals. POM analysis further unveils a reduction in spherical crystal size and gradual blurring of grain boundaries during the annealing process.Highlights
PP/EVA/LDH composites are effectively regulated by changing the annealing treatment conditions.
The crystallization behaviors and crystal structure of PP are induced due to synergistic effect of EVA and LDH under annealing treatment.
The toughness of PP is enhanced significantly by synergistic effect of EVA and LDH under annealing treatment.
Ferritin‐based disruptor nanoparticles: A novel strategy to enhance LDL cholesterol clearance via multivalent inhibition of PCSK9–LDL receptor interaction
Authors: Incocciati Alessio , Cappelletti Chiara , Masciarelli Silvia , Liccardo Francesca , Piacentini Roberta , Giorgi Alessandra , Bertuccini Lucia , De Berardis Barbara , Fazi Francesco , Boffi Alberto , Bonamore Alessandra , Macone Alberto 
Published: August 2024

AbstractHypercholesterolemia, characterized by elevated low‐density lipoprotein (LDL) cholesterol levels, is a significant risk factor for cardiovascular disease. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a crucial role in cholesterol metabolism by regulating LDL receptor degradation, making it a therapeutic target for mitigating hypercholesterolemia‐associated risks. In this context, we aimed to engineer human H ferritin as a scaffold to present 24 copies of a PCSK9‐targeting domain. The rationale behind this protein nanoparticle design was to disrupt the PCSK9–LDL receptor interaction, thereby attenuating the PCSK9‐mediated impairment of LDL cholesterol clearance. The N‐terminal sequence of human H ferritin was engineered to incorporate a 13‐amino acid linear peptide (Pep2‐8), which was previously identified as the smallest PCSK9 inhibitor. Exploiting the quaternary structure of ferritin, engineered nanoparticles were designed to display 24 copies of the targeting peptide on their surface, enabling a multivalent binding effect. Extensive biochemical characterization confirmed precise control over nanoparticle size and morphology, alongside robust PCSK9‐binding affinity (KD in the high picomolar range). Subsequent efficacy assessments employing the HepG2 liver cell line demonstrated the ability of engineered ferritin's ability to disrupt PCSK9–LDL receptor interaction, thereby promoting LDL receptor recycling on cell surfaces and consequently enhancing LDL uptake. Our findings highlight the potential of ferritin‐based platforms as versatile tools for targeting PCSK9 in the management of hypercholesterolemia. This study not only contributes to the advancement of ferritin‐based therapeutics but also offers valuable insights into novel strategies for treating cardiovascular diseases.
Molecular basis of the interactions between the disordered Neh4 and Neh5 domains of Nrf2 and CBP/p300 in oxidative stress response
Authors: Karunatilleke Nadun C. , Brickenden Anne , Choy Wing‐Yiu 
Published: August 2024

AbstractNuclear factor erythroid 2‐related factor 2 (Nrf2) is a major transcription factor that functions in maintaining redox homeostasis in cells. It mediates the transcription of cytoprotective genes in response to environmental and endogenous stresses to prevent oxidative damage. Thus, Nrf2 plays a significant role in chemoprevention. However, aberrant activation of Nrf2 has been shown to protect cancer cells from apoptosis and contribute to their chemoresistance. The interaction between Nrf2 and CBP is critical for the gene transcription activation. CBP and its homologue p300 interact with two transactivation domains in Nrf2, Neh4, and Neh5 domains through their TAZ1 and TAZ2 domains. To date, the molecular basis of this crucial interaction is not known, hindering a more detailed understanding of the regulation of Nrf2. To close this knowledge gap, we have used a set of biophysical experiments to dissect the Nrf2‐CBP/p300 interactions. Structural properties of Neh4 and Neh5 and their binding with the TAZ1 and TAZ2 domains of CBP/p300 were characterized. Our results show that the Neh4 and Neh5 domains of Nrf2 are intrinsically disordered, and they both can bind the TAZ1 and TAZ2 domains of CBP/p300 with micromolar affinities. The findings provide molecular insight into the regulation of Nrf2 by CBP/p300 through multi‐domain interactions.
Profiling of coronaviral Mpro and enteroviral 3Cpro specificity provides a framework for the development of broad‐spectrum antiviral compounds
Authors: Rut Wioletta , Groborz Katarzyna , Sun Xinyuanyuan , Hilgenfeld Rolf , Drag Marcin 
Published: August 2024

AbstractThe main protease from coronaviruses and the 3C protease from enteroviruses play a crucial role in processing viral polyproteins, making them attractive targets for the development of antiviral agents. In this study, we employed a combinatorial chemistry approach—HyCoSuL—to compare the substrate specificity profiles of the main and 3C proteases from alphacoronaviruses, betacoronaviruses, and enteroviruses. The obtained data demonstrate that coronavirus Mpros exhibit overlapping substrate specificity in all binding pockets, whereas the 3Cpro from enterovirus displays slightly different preferences toward natural and unnatural amino acids at the P4‐P2 positions. However, chemical tools such as substrates, inhibitors, and activity‐based probes developed for SARS‐CoV‐2 Mpro can be successfully applied to investigate the activity of the Mpro from other coronaviruses as well as the 3Cpro from enteroviruses. Our study provides a structural framework for the development of broad‐spectrum antiviral compounds.
Carnitine consumption and effect of oral supplementation in human pulmonary arterial hypertension: A pilot study
Authors: Brittain Evan L. , Lindsey Alisha , Burke Kelly , Agrawal Vineet , Robbins Ivan , Pugh Meredith , Calcutt M. Wade , Mallugari Ravi , West James , Nian Hui , Hemnes Anna R. 
Published: August 2024

AbstractCarnitine is required to transport fatty acid across the mitochondrial membrane to undergo beta oxidation. In addition to disorders of fatty acid metabolism, a relative carnitine deficiency has been reported in pulmonary arterial hypertension (PAH). Here we performed an observational study in which food and supplement consumption were collected in an observation period followed by open label administration of a carnitine supplement to determine feasibility of increasing plasma carnitine levels in humans PAH. We confirmed that relative carnitine deficiency in PAH is not due to reduced dietary consumption and that plasma levels of carnitine can be increased in PAH patients with supplementation that is well tolerated.