bluuebunny/crossref_metadata_2025_split huggingface dataset:
ACV with/without IVM: a new talk on intestinal CDX2 and muscular CD34 and Cyclin D1 during Trichinella spiralis infection
Authors: El Saftawy E. A. , Aboulhoda B. E. , Hassan F. E. , Ismail M. A. M. , Alghamdi M. A. , Hussein S. M. , Amin N. M. 
Published: July 2024

Summary
The current study assessed the efficacy of Acyclovir (ACV) and Ivermectin (IVM) as monotherapies and combined treatments for intestinal and muscular stages of Trichinella spiralis infection. One-hundred Swiss albino mice received orally 250 ± 50 infectious larvae and were divided into infected-untreated (Group-1), IVM-treated (Group-2), ACV-treated (Group-3), combined IVM+ACV (Group-4), and healthy controls (Group-5). Each group was subdivided into subgroup-A-enteric phase (10 mice, sacrificed day-7 p.i.) and subgroup-B-muscular phase (10 mice, sacrificed day-35 p.i.). Survival rate and body weight were recorded. Parasite burden and intestinal histopathology were assessed. In addition, immunohistochemical expression of epithelial CDX2 in the intestinal phase and CyclinD1 as well as CD34 in the muscular phase were evaluated. Compared, IVM and ACV monotherapies showed insignificant differences in the amelioration of enteric histopathology, except for lymphocytic counts. In the muscle phase, monotherapies showed variable disruptions in the encapsulated larvae. Compared with monotherapies, the combined treatment performed relatively better improvement of intestinal inflammation and reduction in the enteric and muscular parasite burden. CDX2 and CyclinD1 positively correlated with intestinal inflammation and parasite burden, while CD34 showed a negative correlation. CDX2 positively correlated with CyclinD1. CD34 negatively correlated with CDX2 and CyclinD1. IVM +ACV significantly ameliorated CDX2, CyclinD1, and CD34 expressions compared with monotherapies. Conclusion. T. spiralis infection-associated inflammation induced CDX2 and CyclinD1 expressions, whereas CD34 was reduced. The molecular tumorigenic effect of the nematode remains questionable. Nevertheless, IVM +ACV appeared to be a promising anthelminthic anti-inflammatory combination that, in parallel, rectified CDX2, CyclinD1, and CD34 expressions.
Ovarian balls (Floating ovaries) of Rhadinorhynchus niloticus Mohamadain, 1989 from the Nile perch Lates niloticus Linnaeus, 1758; an electron microscope study
Authors: El-Siefy A. M. , Ibraheem M. H. , Abd El-Kareem S. G. 
Published: July 2024

Summary
In Acanthocephala, the ovarian balls (floating ovaries) are distinctive structures found suspended in the fluid-filled metasoma of females and are responsible for egg production and maturation. Those structures have not been studied in Rhadinorhynchus niloticus. We aimed to investigate their ultra-structure by means of scanning and transmission electron microscopy. A total of 30 Lates niloticus fish individuals were collected by fishermen from the River Nile, Egypt, and the isolated adult female specimens were processed for electron microscopy studies. The ovarian balls are elongated and lobulated structures freely scattered in the metasoma. They exhibited three distinct primary structural zones, a central oogonial syncytium, a peripheral cellular zone and a surrounding somatic supporting syncytium. The oogonia, within the central syncytium, give rise to developing oocytes that transform into mature oocytes. The latter enclose some inclusions such as large yolk granules and smaller egg-shell granules. We also describe the process of fertilization within the ovarian ball. The structure of the ovarian ball and the steps of fertilization in R. niloticus are described, for the first time, in the present study.
Molecular characterization of Bertiella studeri infecting a primate in South India
Authors: Sebasteena P. F. , Deepa C. K. , Varghese A. , Ajith Kumar K. G. , Joy A. , Iype A. , Rajappan A. , Chandy G. , Ravindran R. 
Published: July 2024

Summary

Bertiella spp. is a mite-borne cestode parasite that inhabits the small intestine of wide range of mammals, including non-human primates. In the present study, the morphological and molecular analysis of Bertiella studeri recovered from the small intestine of a bonnet macaque (Macaca radiata) from Wayanad, Kerala (South India) was performed. Acetic alum carmine staining identified the cestode morphologically based on the characters like broader proglottids, which contain irregularly alternating genital pores, single set of reproductive organs, 280 testes and a tubular transverse uterus. Molecular characterization was done using 18SrRNA, ITS1-5.8S and COX1 genes. Phylogenetic trees were constructed using MEGA X based on the Maximum Likelihood (ML) method (Hasegawa-Kishino-Yano (HKY) model). Cytochrome oxidase I gene could detect the existence of genetic variation in the parasite from two different hosts viz., monkey (Kerala, Argentina, and Kenya) and human (Sri Lanka). A minimum spanning network of haplotypes was generated by the haplotype networking with the above sequences using the popARTv1.7. Haplotype analysis based on COX1 revealed that the parasite haplotype was different in each country with highest population frequency in Sri Lanka.
Gastrointestinal parasitic helminths of bats from a cave in Luzon Island, Philippines
Authors: Duco R. A. J. , Villancio G. G. , Paller V. G. V. , Alviola P. A. 
Published: July 2024

Summary
Bats are often associated with several zoonotic diseases, including helminth infections. Despite their potential detrimental effects on both human and bat populations, information on helminth parasites of Philippine bats remains scarce. Here, we identify gastrointestinal helminths parasitizing bats collected from a cave complex in Cavinti, Laguna Province, Philippines, determine their prevalence (P) and mean intensity (MI), and investigate relationship of helminth prevalence and intensity with bat host characteristics including sex, diet, age, and roosting habit. We isolated 581 individuals of helminths representing six taxa (three trematodes, two nematodes, one cestode) from the gastrointestinal tract of sampled bats. Helminths were observed in 82 out of 172 bats captured (P = 47.67%), with Miniopterus paululus having the highest infection rate (P = 91.3%) and highest MI (18 ± 4.5/infected bat). Helminths parasitizing endemic bat species from the Philippines, such as Rhinolophus rufus, Rhinolophus inops, Hipposideros pygmaeus, and Ptenochirus jagori were reported here for the first time. We provide new host records for other helminth species and report the presence of two parasites, Plagiorchis sp. and Toxocara sp., known for their zoonotic potential. These data will contribute to efforts in identifying parasites and diseases harbored by bats in the country and develop additional conservation measures for bats.
Gastrointestinal parasites in captive wild birds in Mineiros, Goiás, Brazil
Authors: Moraes I. S. , Moreira R. M. P. , Duarte R. B. , Prates L. S. , Alves-Ribeiro B. S. , Ferraz H. T. , Pacheco R. C. , Braga Í. A. , Saturnino K. C. , Ramos D. G. S. 
Published: July 2024

Summary
Studying parasites in captive wild birds is vital for their health, well-being, biodiversity preservation, species conservation, and safeguarding of both individual birds and ecosystems. It holds significance for public health by identifying potential zoonotic risks. We aimed to describe the occurrence of gastrointestinal parasites in captive wild birds from a Conservation Institute in Brazilian Cerrado biome. Fresh fecal samples were collected from 17 captive wild birds (Anodorhynchus hyacinthinus, Ara ararauna, Ara chloropterus, Ara macao, Megascops choliba, Pteroglossus castanotis, Ramphastos dicolorus, Ramphastos tucanus and Strix huhula) at a Conservation Institution in Mineiros, state of Goiás. The samples were processed for Willis’ simple flotation and Hoffman’s spontaneous sedimentation examinations to identify parasitic forms of gastrointestinal endoparasites. Macaw aviary birds (Ar. ararauna, Ar. chloropterus and Ar. macao) showed higher positivity, with all six fecal samples positive for helminths or protozoa. In contrast, captive toucans showed only two positive results (P. castanotis and R. dicolorus). An. hyacinthinus showed Ascarididae, Capillarinae and Trematoda eggs; whereas S. huhula had Ascarididae eggs. Regular parasitological examinations are essential for the timely detection and treatment of gastrointestinal infections in captive birds, thereby enhancing overall bird management.
Potential of frangipani flower (Plumeria sp.) as a source of antibacterial and antioxidants and its application in the pharmacological activities
Authors: CANDRA KRISHNA PURNAWAN , LESTARI GISTI MALINDA , PRABOWO SULISTYO , YULIANI YULIANI , MARWATI MARWATI , RACHMAWATI MAULIDA 
Published: July 2024

Frangipani (Plumeria spp.) was a flowering ornamental plant with several metabolites that can be used as traditional medicine for various diseases such as laxative, anti-itch, anti-inflammatory, diabetic, and malaria. The Frangipani flower showed antibacterial activity against E. coli, P. aeruginosa, S. aureus, C. albicans, S. pyogenes, S. typhi, B. pumilus, B. subtilis, S. dysenteriae, P. mirabilis, P. fluorescens, B. cereus, S. flexneri, and M. furfur. Frangipani flowers also have high antioxidant activity due to their significant phenol and flavonoid content. This study provided an overview of the application of Frangipani flowers for pharmaceutical purposes.
A case report on pancreatic plasmacytoma presenting as obstructive jaundice
Authors: Tafader Asiya , Nadeem Mahum , Spataro Joseph 
Published: July 2024

Background:
Extramedullary solitary plasmacytomas (EMD) are an uncommon manifestation of plasma cell disorders. The median survival rate is less than 6 months. EMD rarely involves the digestive tract, the liver is the most common site with only a 2.3% incidence rate for pancreatic involvement.

Case Presentation:
We report a case of a patient with a history of multiple myeloma who presented with painless obstructive jaundice and EUS findings of hypoechoic, solid irregular mass in the pancreatic head with surrounding peripancreatic lymphadenopathy. Fine needle aspirate (FNA) confirmed malignant infiltration of plasma cell neoplasm. The patient rapidly deteriorated and succumbed to his illness within 6 weeks of diagnosis.

Conclusion:
Extramedullary plasmacytomas (EMD) involving the pancreas are uncommon and associated with a poor prognosis. Our case highlights the importance of considering extramedullary plasmacytoma when a patient with MM presents with a pancreatic mass, particularly one showing a rapid interval growth. This rate of growth is not seen with primary pancreatic parenchymal diseases such as cancer, cysts, and so on. This case highlights the importance of considering rare differentials while evaluating patients with pancreatic mass.
Rare and lethal: a case report on the grim reality of EMD infiltrating the pancreas. Despite its rarity, timely recognition is crucial for improved outcomes in patients with multiple myeloma. #MedTwitter #Oncology #CaseReport”
Demokrasi dalam Arena Media Sosial: Catatan Refleksi Pembelajaran pada Masa Kampanye Pemilihan Presiden 2024
Authors: Puspitasari Maria 
Published: July 2024

Kampanye pemilihan presiden 2024 dalam arena media sosial dapat menjadi salah satu parameter yang digunakan untuk menilai praktek demokrasi deliberatif. Penelitian dilakukan pada tiga akun media sosial dari kandidat presiden 2024. Menggunakan analisis isi kualitatif, penelitian dilakukan pada kurun waktu Desember 2023-Februari 2024 Penelitian menunjukkan pemanfaatan beberapa teknik untuk memasarkan gagasan dan meraih suara pemilih melalui visualisasi simbolik. Pemanfaatan simbol-simbol yang dimaknai secara khas oleh generasi Z sebagai kelompok sasaran utama yang memperkuat alasan untuk memilih. Penggunaan strategi berdasarkan elemen populisme mendorong terjadinya perubahan dalam wajah demokrasi deliberatif, dimana partisipasi menjadi elemen yang dikapitalisasi oleh tim kampanye dan berdampak panjang pada perubahan wajah demokrasi.
Value Co-Creation and Sustainability Communication: A Case Study of Lyfe With Less’ Instagram and Telegram
Authors: Brodjonegoro Snezana Swasti 
Published: July 2024

Globally, the term sustainability has been widely used since its first inception back in the 1990s. However, the term itself has only been popularly used in Indonesia for the past half-decade, following the initiation of the Sustainable Development Goals by the UN, which Indonesia supported. Since then, there have been numerous sustainability initiatives by civil communities that are based online. These communities somewhat became the ‘spearheads’ of sustainable consumption communication in Indonesia, educating netizens about various aspects of sustainable consumption, through various platforms – including Instagram and Telegram. This paper aims to analyze how followers and group-members co-create value related to sustainable consumption and lifestyle across the two communication platforms of a sustainable lifestyle online community: Lyfewithless. This paper employs qualitative approach, using value co-creation concept to understand the interaction and communication pattern on both Instagram & Telegram, and communication about/of sustainability as a macro lens to situate this case in the growing body of sustainability communication. Through analyzing the interaction on both platforms during the period of February-May 2022 and February-May 2023, this study shows that the Instagram account & Telegram group of Lyfewithless have slightly different value co-creation dynamics and levels, but complement each other to co-create value among its members and followers in building and rebuilding understanding about sustainable consumption. Furthermore, this study proposes that to achieve its intended impact, organizations must conduct both communication aboutsustainability and communication of sustainability. This study contributes to the sustainable consumption communication literature and supports the notion that civil communities hold important role in educating more people to adapt a more sustainable consumption behavior in the Indonesian context.
Information Needs to Influence the Quality of Development Messages and News in the Digital Media Era
Authors: Indrati Iman , Sumardjo Sumardjo , Hapsari Dwi Retno , Fatchiya Anna 
Published: July 2024

The presence of development journalists is needed to criticize, study, evaluate, and report on the relevance of development projects. The press, as the fourth pillar of democracy, has a very crucial role in conveying criticism. The research aims to analyze the influence of society's information needs (X1), politics (X2), and government (X3) on the quality of development messages (Y1) and news (Y2). The research methodology uses a mixed-methods approach with a sequential explanation strategy. The research population covers television news viewers and observers. The research sample consisted of 110 respondents who were viewers and observers of news broadcasts in mainstream media. The research results show: (1) there is a significant influence between the information need variable based on the community perspective (X1) on the quality of development messages (Y1); (2) there is no significant influence between the variable information needs based on the perspective of the business world (X2), politics (X3), and government (X4) on news quality (Y2), but there is an influence of public information needs (X1) on news quality (Y2). Based on information from press representative institutions, there was a decline in quality caused by: (1) complaints of violations from the Indonesian Broadcasting Institution; (2) less attractive news packaging; (4) social media competition; (5) in-depth news analysis; (6) intervention from stakeholders; (7) lack of cross-sectoral support; and (8) the small compensation received by journalists. In conclusion, information needs based on society's perspective do not influence the quality of development messages but do influence the quality of news.
The Social Media Marketing Mix Trends in Indonesia for 2024: Communication Perspective
Authors: Pandjaitan Rosmawaty Hilderiah 
Published: July 2024

Background: 86% of marketers believe social media marketing mix trends have influenced their profits. This condition significantly changes the business world and offers integrated marketing communications strategy options.This is a qualitative research in the interpretive paradigm. Using netnography or virtual ethnography or digital ethnography methods, this research attempts to explore and analyze the complex meaning of Indonesia's latest social media statistical data, compiled from We Are Social and The Global Statistics. We support data from Pew Research Center, Statista, Deloitte, Forbes, Insider Intelligence, Forrester, LinkedIn, GlobalWebIndex, CMO Survey, and the FGD (Focus Group Discussion) method. The analytical tools used are Computer-Mediated Communication Theory, Everett Rogers' Theory of Diffusion of Innovation, etc. In 2024, the social media marketing mix (SMMM) will be dominated by Artificial Intelligence (A.I.) including Generative A.I. and ChatGPT technology, as well as creative content that is entertaining and capable of attracting various kinds of people, and creates social polemics too. The principle, "Give what they want, take what you need," is used to get support from Gen Z and Millennials. This principle is needed to build trust and loyalty. Many companies will carry out promotions focusing only on social media platforms that provide benefits, and social media trends in Indonesia include Instagram, Facebook, TikTok, and Twitter. The promotional message will consist of product quality, price, and comfort. These three aspects will also be communicated extensively using A.I. technology and ChatGPT.
Internalizing Pancasila Values among the Younger Generation in Jakarta in the Context of the 2024 Presidential Election in Indonesia
Authors: Yuniar Ririt , Ahsan Titania Fattiha 
Published: July 2024

The internalization of Pancasila values among the younger generation is significant for a more in-depth study ahead of the 2024 presidential election in Indonesia. This has become a hot issue as material for study, especially after the 2024 presidential and vice presidential candidate debate took place. This research aims at 3 things: First, to inform the importance of internalizing the Pancasila values among the younger generation to welcome the 2024 election; Second, to instill Pancasila values in the younger generation in responding to currently developing political dynamics; Third, to strengthen implementation of Pancasila values in political ethics by socializing them among the younger generation to realize peaceful elections in 2024. The mixed method used for this research is quantitative data collection, using qualitative descriptive techniques with text analysis. The distribution of questionnaires conducted directly and online is based on the theory of social reality construction, with the concept of internalization being the focus. This research shows 3 things: First, the younger generation received information regarding the importance of internalizing Pancasila values in creating peaceful elections in 2024. Second, researchers succeeded in socializing the effort to instil Pancasila values in the younger generation in responding to political dynamics in the 2024 elections. Third, ethical politics in peaceful elections have been socialized by strengthening Pancasila values to make the situation more conducive to implementing peaceful elections. It is hoped that this research can become a consistent and sustainable national movement for the upcoming elections and prepare the younger generation to have a peaceful and constructive mentality.
Tourism Communication Policy in Sustainable Tourism and Climate Change in Garut Regency
Authors: Sunuantari Manik , Klicek Tamara 
Published: July 2024

The tourism sector as one of the drivers of the Indonesian economy is also affected by natural and non-natural disasters. Climate change and disasters encourage the government of Garut Regency in West Java, Indonesia, to carry out various tourism communication policies as part of the effort to increase sustainable tourism activities in the face of climate change and disasters. This research aims to find a model of sustainable tourism communication policy in the face of climate change in Garut Regency. This research uses symbolic interactionism theory, growth pole theory and Community Based Tourism (CBT). The exchange of symbols between tourism actors will build a common meaning in making sustainable tourism communication policies. The type of research used a case study with a research location in Garut Regency, a tourist site as well as a disaster-prone area. Data collection techniques were carried out through observation, interviews and documentation. Data validity used data triangulation, investigator triangulation, and theory triangulation. The results showed that the policy used in the development of sustainable tourism in Garut Regency emphasizes collaboration and communication of all stakeholders. The involvement of all stakeholders will encourage the realization of community welfare. The focus of sustainable tourism development is the community. Community welfare will be achieved if the community is fully involved in all tourism activities.
Debate on Rice Import Policy in Indonesia: Discourse Network Analysis in Online Media
Authors: Amrihani Haresti Asysy , Eriyanto Eriyanto , Zulkifli Muhammad Yunus 
Published: July 2024

This research maps the discourses on agreements and disagreements of each actor regarding the rice import policy in Indonesia. In 2023, the Indonesian government took a policy to increase the quota of rice imports Indonesia, according to the United States Department of Agriculture, is the world’s fifth largest country in terms of rice imports. The policy was opposed and supported by a number of actors since Indonesia is also the fourth largest rice producer in the world. Actors who oppose and approve of the rice import policy in Indonesia present their respective arguments to influence the public. This research uses the Discourse Network Analysis (DNA) method to map the discourse coalition and actors based on the actors' arguments in Kompas.id media. The results show that the discourses of each actor are connected to each other. The discourses include: stabilizing rice reserves, international cooperation, reducing rice prices, anticipating climate change, importing rice during harvest, contradicting the food law, rising rice prices, rice stock alert, law enforcement against rice fraud, and rice procurement which is impossible.
Marketing and Personal Branding of Anies Baswedan as Presidential Candidate by NasDem Party in Digital Space
Authors: Khabir Muhammad Hazim , Suswanta Suswanta , Al-hamdi Ridho 
Published: July 2024

The purpose of this study is to see the phenomenon of political marketing, especially how the online mass media builds Anies Baswedan’s branding as a presidential candidate. The branding of presidential candidate serves as a phenomenon of Indonesian national politics particularly when NasDem Party declared Anies Baswedan as a presidential candidate on October 3, 2022. The methodology of this study uses qualifiers, and the technique of analysis and data analysis uses Nvivo12 plus mainly in online media reporting in Indonesia (CNN, Kompas, Media Indonesia, and Detik.com). The results of this study showed that the four media outlets were actively reporting on the nomination of Anies as a presidential candidate. The massive reporting put Anies' personal electability ahead of other political opponents. The identification is based on the analysis of content about Anies in the four online media outlets. In terms of quantity, Media Indonesia more actively reported on Anes’ candidacy than the other three media outlets. This is because of power polarization relationship in terms of ownership relationship between NasDem Party and Media Indonesia. Thus, the news frame leans towards Anies and indirectly it can be used for marketing and branding politics.