bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement in Survival Rates and Quality of Life Among Patients Surgically Treated for Squamous Cell Carcinoma of the Oral Cavity
Authors: Tirelli Giancarlo , Zanelli Enrico , Polesel Jerry , Gardenal Nicoletta , Ramella Vittorio , Mineo Chiara , Zucchini Simone , Piovesana Marco , Grill Vittorio , Giudici Fabiola , Boscolo Nata Francesca , Marcuzzo Alberto , Boscolo-Rizzo Paolo 
Published: July 2024

Abstract
Purpose
The study aimed to assess if outcomes for oral squamous cell carcinoma (OSCC) patients have improved, and if so, whether these improvements correlate with changes in diagnostic and therapeutic methods over time.

Methods
Retrospective study including patients surgically treated for OSCC between 2002 and 2020.

Results
Among the 193 consecutive patients with primary OSCC who met the inclusion criteria (median age 66; 60.4% male), 80 (41.4%) were treated between 2002 and 2011, and 113 (58.6%) between 2011 and 2020. Multivariate analysis showed a significant improvement in overall survival rates from 2012 to 2020, compared with the period from 2002 to 2011 (HR for death, 0.33; 95% CI 0.17–0.67). Similar observations have emerged in progression-free and disease-specific survival. When stratified by stage, the improvement was found to be significant only for advanced stages. The use of NBI during both preoperative and operative setting as well as margin mapping significantly increased over the time. Both patients with early and advanced-stage OSCC treated between 2012 and 2020 exhibited improved pain scores.

Conclusions
Despite the shift to less invasive surgeries, our analysis shows significant improvement over time, especially in advanced-stage diseases, highlighting the impact of evolving strategies on challenging cases.
Community perceptions towards the ecosystem services of urban forests in Mekelle, Tigray, Ethiopia
Authors: Zeratsion Berihu Tesfamariam , Gebreslassie Aster , Gebrewahid Yikunoamlak , Berhe Daniel Hagos , Manaye Ashenafi , Gebru Kebede Manjur , Kifle Bisrat 
Published: July 2024

AbstractUrban forests are crucial providers of ecosystem services, delivering significant benefits to residents and the environment. This study aimed to investigate how residents in Mekelle, Tigray, Ethiopia, perceive the ecosystem services provided by urban forests. Understanding these perceptions is essential, particularly in developing countries and the study area, where little research has been conducted on this topic. To achieve this objective, a questionnaire-based survey was conducted among randomly selected household heads from two sub-cities within Mekelle. The collected data were analyzed using both descriptive and inferential statistics, including Spearman rank correlation and ordinal regression analysis. These analyses helped identify the factors influencing inhabitants’ perceptions of ecosystem services. The findings revealed that residents placed a high value on the regulating ecosystem services provided by urban forests. In contrast, provisioning, supporting, and cultural ecosystem services were perceived at a medium level. Additionally, the analysis indicated that the level of education and age of respondents were significant factors influencing their overall perception of these ecosystem services. Higher educational attainment and older age were associated with a greater appreciation of the ecosystem services offered by urban forests. This study has important implications for urban forest management and policy. It highlights the necessity of incorporating community perceptions of ecosystem services into urban planning and management efforts. Moreover, the study recommends the need for local governments to focus on raising community awareness about the ecosystem services provided by urban forests. This can ensure more effective and inclusive urban forest management strategies that align with community values and needs.
Differential Responses of Soil Phosphorus Fractions to Nitrogen and Phosphorus Fertilization: A Global Meta‐Analysis
Authors: Yu Qingshui , Hagedorn Frank , Penuelas Josep , Sardans Jordi , Tan Xiangping , Yan Zhengbing , He Chenqi , Ni Xiaofeng , Feng Yuhao , Zhu Jiangling , Ji Chengjun , Tang Zhiyao , Li Mai‐He , Fang Jingyun 
Published: July 2024

AbstractAnthropogenic inputs of nitrogen (N) and phosphorus (P) to terrestrial ecosystems alter soil nutrient cycling. However, the global‐scale responses of soil P fractions to N and P inputs and their underlying mechanisms remain elusive. We conducted a global meta‐analysis based on 818 observations of soil P fractions from 99 field N and P addition experiments in forest, grassland, and cropland ecosystems ranging from temperate to tropical zones. Our global meta‐analysis revealed distinct responses of soil P fractions to N and P enrichment. For studies using the Chang and Jackson inorganic (Pi) method, we found that high N addition promoted the transformation of immobile Pi fractions into Ferrum/Aluminum‐bound Pi and available Pi in surface soils through soil acidification. However, this acid‐induced transformation of Pi fractions by N addition was observed only in Calcium‐rich soils, while in acidic soils, further acidification led to increase P binding. In contrast, additions of P alone or combined with N significantly increased all soil Pi fractions. Regarding the Hedley P fractions, N addition generally decreased labile organic P by enhancing soil acid phosphatase activity. The responses of other P fractions were influenced by soil pH, fertilization rates, ecosystem type, and other factors. P addition increased most soil P fractions. Overall, both P fractionation methods consistently demonstrate that N inputs deplete soil P and accelerate P cycling, while P inputs increase most soil P fractions, alleviating P limitation. These findings are crucial for predicting the effects of future atmospheric N and P deposition on P cycling processes.
Deficiency of SIAH1 promotes the formation of filopodia by increasing the accumulation of FASN in liver cancer
Authors: Liu Zhiyi , Hu Qinghe , Cao Kuan , Sun Jun , Cui Licheng , Ji Mengxuan , Shan Wengang , Yang Weichao , Zhang Guowei , Tian Zilu , Shi Hengliang , Zhang Bin , Wang Renhao 
Published: July 2024

AbstractIt has been shown that the formation of filopodia is a key step in tumor cell metastasis, but there is limited research regarding its mechanism. In this study, we demonstrated that fatty acid synthase (FASN) promoted filopodia formation in liver cancer cells by regulating fascin actin-bundling protein 1 (FSCN1), a marker protein for filopodia. Mechanistically, on the one hand, the accumulation of FASN is caused by the enhanced deubiquitination of FASN mediated by UCHL5 (ubiquitin c-terminal hydrolase L5). In this pathway, low expression of SIAH1 (Seven in absentia homolog 1) can decrease the ubiquitination and degradation of ADRM1 (adhesion regulating molecule 1) thereby increasing its protein level, which will recruit and activate the deubiquitination enzyme UCHL5, leading to FASN undergo deubiquitination and escape from proteasomal degradation. On the other hand, the accumulation of FASN is related to its weakened ubiquitination, where SIAH1 directly acts as a ubiquitin ligase toward FASN, and low expression of SIAH1 reduces the ubiquitination and degradation of FASN. Both the two pathways are involved in the regulation of FASN in liver cancer. Our results reveal a novel mechanism for FASN accumulation due to the low expression of SIAH1 in human liver cancer and suggest an important role of FASN in filopodia formation in liver cancer cells.
Deubiquitinase USP9x regulates the proline biosynthesis pathway in non-small cell lung cancer
Authors: Becirovic Tina , Zhang Boxi , Lindskog Cecilia , Norberg Erik , Vakifahmetoglu-Norberg Helin , Kaminskyy Vitaliy O. , Kochetkova Elena 
Published: July 2024

AbstractMetabolic rewiring has been recognized as a hallmark of malignant transformation, supplying the biosynthetic and energetic demands for rapid cancer cell proliferation and tumor progression. A comprehensive understanding of the regulatory mechanisms governing these metabolic processes is still limited. Here, we identify the deubiquitinase ubiquitin-specific peptidase 9 X-linked (USP9x) as a positive regulator of the proline biosynthesis pathway in non-small cell lung cancer (NSCLC). Our findings demonstrate USP9x directly stabilizes pyrroline-5-carboxylate reductase 3 (PYCR3), a key enzyme in the proline cycle. Disruption of proline biosynthesis by either USP9x or PYCR3 knockdown influences the proline cycle leading to a decreased activity of the connected pentose phosphate pathway and mitochondrial respiration. We show that USP9x is elevated in human cancer tissues and its suppression impairs NSCLC growth in vitro and in vivo. Overall, our study uncovers a novel function of USP9x as a regulator of the proline biosynthesis pathway, which impacts lung cancer growth and progression, and implicates a new potential therapeutic avenue.
Complex behavior from intrinsic motivation to occupy future action-state path space
Authors: Ramírez-Ruiz Jorge , Grytskyy Dmytro , Mastrogiuseppe Chiara , Habib Yamen , Moreno-Bote Rubén 
Published: July 2024

AbstractMost theories of behavior posit that agents tend to maximize some form of reward or utility. However, animals very often move with curiosity and seem to be motivated in a reward-free manner. Here we abandon the idea of reward maximization and propose that the goal of behavior is maximizing occupancy of future paths of actions and states. According to this maximum occupancy principle, rewards are the means to occupy path space, not the goal per se; goal-directedness simply emerges as rational ways of searching for resources so that movement, understood amply, never ends. We find that action-state path entropy is the only measure consistent with additivity and other intuitive properties of expected future action-state path occupancy. We provide analytical expressions that relate the optimal policy and state-value function and prove convergence of our value iteration algorithm. Using discrete and continuous state tasks, including a high-dimensional controller, we show that complex behaviors such as “dancing”, hide-and-seek, and a basic form of altruistic behavior naturally result from the intrinsic motivation to occupy path space. All in all, we present a theory of behavior that generates both variability and goal-directedness in the absence of reward maximization.
Electrochemical on-surface synthesis of a strong electron-donating graphene nanoribbon catalyst
Authors: Sakaguchi Hiroshi , Kojima Takahiro , Cheng Yingbo , Nobusue Shunpei , Fukami Kazuhiro 
Published: July 2024

AbstractOn-surface synthesis of edge-functionalized graphene nanoribbons (GNRs) has attracted much attention. However, producing such GNRs on a large scale through on-surface synthesis under ultra-high vacuum on thermally activated metal surfaces has been challenging. This is mainly due to the decomposition of functional groups at temperatures of 300 to 500 °C and limited monolayer GNR growth based on the metal catalysis. To overcome these obstacles, we developed an on-surface electrochemical technique that utilizes redox reactions of asymmetric precursors at an electric double layer where a strong electric field is confined to the liquid-solid interface. We successfully demonstrate layer-by-layer growth of strong electron-donating GNRs on electrodes at temperatures <80 °C without decomposing functional groups. We show that high-voltage facilitates previously unknown heterochiral di-cationic polymerization. Electrochemically produced GNRs exhibiting one of the strongest electron-donating properties known, enable extraordinary silicon-etching catalytic activity, exceeding those of noble metals, with superior photoconductive properties. Our technique advances the possibility of producing various edge-functional GNRs.
Longitudinal variation in resilient psychosocial functioning is associated with ongoing cortical myelination and functional reorganization during adolescence
Authors: Hettwer Meike D. , Dorfschmidt Lena , Puhlmann Lara M. C. , Jacob Linda M. , Paquola Casey , Bethlehem Richard A. I. ,   NSPN Consortium, Bullmore Edward T. , Eickhoff Simon B. , Valk Sofie L. 
Published: July 2024

AbstractAdolescence is a period of dynamic brain remodeling and susceptibility to psychiatric risk factors, mediated by the protracted consolidation of association cortices. Here, we investigated whether longitudinal variation in adolescents’ resilience to psychosocial stressors during this vulnerable period is associated with ongoing myeloarchitectural maturation and consolidation of functional networks. We used repeated myelin-sensitive Magnetic Transfer (MT) and resting-state functional neuroimaging (n = 141), and captured adversity exposure by adverse life events, dysfunctional family settings, and socio-economic status at two timepoints, one to two years apart. Development toward more resilient psychosocial functioning was associated with increasing myelination in the anterolateral prefrontal cortex, which showed stabilized functional connectivity. Studying depth-specific intracortical MT profiles and the cortex-wide synchronization of myeloarchitectural maturation, we further observed wide-spread myeloarchitectural reconfiguration of association cortices paralleled by attenuated functional reorganization with increasingly resilient outcomes. Together, resilient/susceptible psychosocial functioning showed considerable intra-individual change associated with multi-modal cortical refinement processes at the local and system-level.
The small CRL4CSA ubiquitin ligase component DDA1 regulates transcription-coupled repair dynamics
Authors: Llerena Schiffmacher Diana A. , Lee Shun-Hsiao , Kliza Katarzyna W. , Theil Arjan F. , Akita Masaki , Helfricht Angela , Bezstarosti Karel , Gonzalo-Hansen Camila , van Attikum Haico , Verlaan-de Vries Matty , Vertegaal Alfred C. O. , Hoeijmakers Jan H. J. , Marteijn Jurgen A. , Lans Hannes , Demmers Jeroen A. A. , Vermeulen Michiel , Sixma Titia K. , Ogi Tomoo , Vermeulen Wim , Pines Alex 
Published: July 2024

AbstractTranscription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA polymerase II at DNA lesions, which triggers the assembly of the TC-NER-specific proteins CSA, CSB and UVSSA. CSA, a WD40-repeat containing protein, is the substrate receptor subunit of a cullin-RING ubiquitin ligase complex composed of DDB1, CUL4A/B and RBX1 (CRL4CSA). Although ubiquitination of several TC-NER proteins by CRL4CSA has been reported, it is still unknown how this complex is regulated. To unravel the dynamic molecular interactions and the regulation of this complex, we apply a single-step protein-complex isolation coupled to mass spectrometry analysis and identified DDA1 as a CSA interacting protein. Cryo-EM analysis shows that DDA1 is an integral component of the CRL4CSA complex. Functional analysis reveals that DDA1 coordinates ubiquitination dynamics during TC-NER and is required for efficient turnover and progression of this process.
Analyzing resilience influencing factors in the prefabricated building supply chain based on SEM-SD methodology
Authors: Lin Mingchao , Ren Yifei , Feng Chao , Li Xiaojuan 
Published: July 2024

AbstractThe supply chain for prefabricated buildings (PB) currently grapples with pressing challenges. In order to ensure the safe and stable development of the prefabricated building supply chains (PBSC), this study aims to identify the key factors and internal mechanisms affecting the PBSC, and propose a supply chain resilience enhancement mechanism, so as to promote the sustainable development of the PB industry. The study combined a literature review and survey data to identify key resilience factors in PBSC. A Structural Equation Model (SEM) was used to explore the relationships between these factors. System dynamics were applied to create a simulation model, assessing the resilience impact level and conducting sensitivity analysis. The results show that the transportation and procurement processes are the most significant factors influencing supply chain resilience. The external environmental factors wielded a more pronounced impact on the overall evaluation of supply chain resilience than the delivery and use processes, but delivery and use processes are more sensitive. The study uses the Pressure-State-Response (PSR) model to suggest strategies for enhancing supply chain resilience. This study contributes to more sustainable and efficient construction practices by offering an innovative theoretical framework to analyze the factors influencing PBSC resilience and proposing enhancement strategies.
Acute Metabolic Response, Neuromuscular Activity, and Mechanical
Performance to Different Set
Authors: Páez-Maldonado José Antonio , Cornejo-Daza PedroJesús , Sánchez-Valdepeñas Juan , Sánchez-Moreno Miguel , Yuzo-Nakamura Fábio , Pareja-Blanco Fernando , Ortega-Becerra Manuel 
Published: July 2024

AbstractThe aim of this study was to examine the acute metabolic response, neuromuscular
activity, and mechanical performance of different set configurations in
bench-press (BP). Twenty-two resistance-trained men performed three resistance
exercise protocols consisting of 3 x 12 BP repetitions at 60% 1RM, with 4
minutes of rest between sets, but with different set configurations: (a)
traditional set (TS), without rest within the set; (b) cluster-6 (CS6), with
30-second intraset rest after the sixth repetition in each set; and (c)
cluster-2 (CS2), with 30-second intraset rest every two repetitions. Mean
propulsive force (MPF), velocity (MPV), power (MPP), and electromyography (EMG)
values were recorded for each repetition. Blood lactate, maximal voluntary
isometric BP contraction, and dynamic strength in BP were assessed pre- and
post-exercise. The CS2 protocol resulted in greater mechanical performance
(i. e. MPF, MPV, and MPP) and lower alterations of EMG parameters (i. e. root
mean square and median frequency) during the exercise compared to CS6 and TS
(TS<CS6<CS2). The CS2 protocol induced smaller increases in lactate
compared to TS and CS6. No significant “protocol x time” interactions were
observed for the MVIC (maximal voluntary isometric BP contraction) variables.
Introducing short but frequent intraset rest periods alleviates training-induced
fatigue assessed by better performance maintenance.
Pediatric Shoulder Girdle
Authors: Farooq Mobeen , Belair Jeffrey A. , Desai Vishal 
Published: July 2024

AbstractThe pediatric shoulder girdle is a complex anatomical structure uniting the upper extremity and trunk. The osseous structures, their articulations, and the surrounding soft tissue support structures (muscles, tendons, and ligaments) allow for a wide range of motion at the shoulder. Growth and maturation of the components at the shoulder girdle vary, particularly the osseous structures. This characteristic renders interpretation of imaging of the pediatric shoulder girdle more challenging because normal or variant anatomy can be confused for pathology. We review the physiologic growth and maturation of the shoulder girdle with special emphasis on the development of the bones and their articulations. The role of various imaging modalities and the common osseous and soft tissue variants in the pediatric shoulder are also discussed.
RBE-based dose planning, and calculation of TCP and NTCP with gold nanoparticles for intermediate photon energy in pancreatic cancer
Authors: Khaledi Navid , Karshafian Raffi , Taggar Amandeep S , Alrabiah Khalid , Khan Rao , Gräfe James L 
Published: July 2024

Abstract

Objective. This study simulated the potential of gold nanoparticles (GNPs) to improve the effectiveness of radiation therapy in pancreatic cancer cases. The purpose of this study was to assess the impact of GNPs on tumor control probability (TCP) and normal tissue complication probability (NTCP) in pancreatic cancer cases undergoing radiation therapy. The work aimed to compare treatment plans generated with a novel 2.5 MV beam using GNPs to conventional 6 MV plans and evaluate the dose-volume histogram (DVH), TCP, and NTCP. Approach. Treatment planning for five pancreatic computed tomography (CT) images was performed using the open-source MATLAB-based treatment planning program matRad. MATLAB codes were developed to calculate the relative biological effectiveness (RBE) of GNPs and apply the corresponding dose and RBE values to each voxel. TCP and NTCP were calculated based on the applied RBE values. Main results. Adding GNPs to the 2.5 MV treatment plan resulted in a significant increase in TCP, from around 59% to 93.5%, indicating that the inclusion of GNPs improved the effectiveness of the radiation treatment. The range in NTCP without GNPs was relatively larger compared to that with GNPs. Significance. The results indicated that the addition of GNPs to a 2.5 MV plan can increase TCP while maintaining a relatively low NTCP value (<1%). The use of GNPs may also reduce NTCP values by decreasing the dose to normal tissues while maintaining the same prescribed dose to the tumor. Hence, the addition of GNPs can improve the balance between TCP and NTCP.
Investigation of the effect of martensitic phase transition temperature and Curie temperature difference on magnetic and magnetocaloric properties under low magnetic field on Si-doped Ni-Mn-In Heusler alloys
Authors: Kavak E , Cicek M M , Saritas S , Emre B 
Published: July 2024

Abstract
This study examines the impact of substituting Si for Mn on the structural, magnetic, and magnetocaloric properties of Ni43Mn46−x
Si
x
In11 (x = 0.3 and 0.6) alloys. To this end, a range of analytical techniques are employed, including scanning electron microscopy (SEM), room temperature x-ray powder diffraction (XRD), and magnetization measurements. Above the martensitic transition temperature, the Ni43Mn46−x
Si
x
In11 alloys exhibit cubic L2
1 (space group FM-3M). Below this temperature they adopt a tetragonal L1
0 (space group I4/mmm). The martensitic transition temperature decreased when Si is substituted for Mn. The magnetic field-induced entropy change is calculated from magnetic field-dependent magnetization measurements using Maxwell’s equations. The maximum magnetic field-induced entropy changes for Ni43.16Mn45.56Si0.29In11 and Ni43.51Mn44.82Si0.59In11 alloys are calculated 8.20 J kg−1K−1 and 3.15 J kg−1 K−1, respectively, in the vicinity of the magnetostructural phase transition for a magnetic field change of 18 kOe. It is demonstrated that the temperature differential between the high-temperature austenite phase's Curie point (T

C
) and the mean martensitic transformation temperature (T

M
), namely (T

M
-T

C
), influences the martensitic transition temperatures and, consequently, on the magnetic field-induced entropy change (ΔS

M
).