bluuebunny/crossref_metadata_2025_split huggingface dataset:
Maternal Education and the Link Between Birth Timing and Children's School Readiness*
Authors: Augustine Jennifer March , Prickett Kate C. , Kendig Sarah M. , Crosnoe Robert 
Published: April 2015

ObjectiveThis study explored whether mothers’ education magnified any benefits that waiting until older ages to have children might have for their children's educational careers.MethodsMultiple‐group path modeling assessed whether and why the positive association between mothers’ age at first birth and children's test scores was greater for children of college‐educated women than children of other women.ResultsOlder age at first birth was associated with higher math and reading test scores among the children of college‐educated women via their mothers’ higher income and cognitive support for children. These mediational paths were less pronounced among the children of high‐school‐educated women and were not observed among the children of high school dropouts.ConclusionAny potential effects of women's delayed fertility on their children's early educational experiences appeared to be confined to the most educated women.
Accelerated healing in NONcNZO10/LtJ type 2 diabetic mice by FGF‐1
Authors: Blaber Sachiko I. , Diaz Jose , Blaber Michael 
Published: April 2015

AbstractThe development of novel therapies to treat chronic diabetic ulcers depends upon appropriate animal models for early stage investigation. The NONcNZO10/LtJ mouse is a new polygenic strain developed to more realistically model human metabolic syndrome and obesity‐induced type 2 diabetes; however, detailed wound healing properties have not been reported. Herein, we describe a quantitative wound healing study in the NONcNZO10/LtJ mouse using a splinted excisional wound. The rate of wound healing is compared to various controls, and is also quantified in response to topical administration of normal and mutant fibroblast growth factor‐1 (FGF‐1). Quantitation of reepithelialization shows that the diabetic condition in the NONcNZO10/LtJ mouse is concomitant with a decreased rate of dermal healing. Furthermore, topical administration of a FGF‐1/heparin formulation effectively accelerates reepithelialization. A similar acceleration can also be achieved by a stabilized mutant form of FGF‐1 formulated in the absence of heparin. Such accelerated rates of healing are not associated with any abnormal histology in the healed wounds. The results identify the NONcNZO10/LtJ mouse as a useful model of impaired wound healing in type 2 diabetes, and further, identify engineered forms of FGF‐1 as a potential “second‐generation” therapeutic to promote diabetic dermal wound healing.
The Inability to Screen Exhibition Swine for Influenza A Virus Using Body Temperature
Authors: Bowman A. S. , Nolting J. M. , Workman J. D. , Cooper M. , Fisher A. E. , Marsh B. , Forshey T. 
Published: April 2015

SummaryAgricultural fairs create an unconventional animal–human interface that has been associated with swine‐to‐human transmission of influenza A virus (IAV) in recent years. Early detection of IAV‐infected pigs at agricultural fairs would allow veterinarians to better protect swine and human health during these swine exhibitions. This study assessed the use of swine body temperature measurement, recorded by infrared and rectal thermometers, as a practical method to detect IAV‐infected swine at agricultural fairs. In our first objective, infrared thermometers were used to record the body surface temperature of 1,092 pigs at the time of IAV nasal swab collection at the end of the exhibition period of 55 agricultural fairs. IAV was recovered from 212 (19.4%) pigs, and the difference in mean infrared body temperature measurement of IAV‐positive and IAV‐negative pigs was 0.83°C. In a second objective, snout wipes were collected from 1,948 pigs immediately prior to the unloading of the animals at a single large swine exhibition. Concurrent to the snout wipe collection, owners took the rectal temperatures of his/her pigs. In this case, 47 (2.4%) pigs tested positive for IAV before they entered the swine barn. The mean rectal temperatures differed by only 0.19°C between IAV‐positive and IAV‐negative pigs. The low prevalence of IAV among the pigs upon entry to the fair in the second objective provides evidence that limiting intraspecies spread of IAV during the fairs will likely have significant impacts on the zoonotic transmission. However, in both objectives, the high degree of similarity in the body temperature measurements between the IAV‐positive and IAV‐negative pigs made it impossible to set a diagnostically meaningful cut point to differentiate IAV status of the individual animals. Unfortunately, body temperature measurement cannot be used to accurately screen exhibition swine for IAV.
The Application of Low Cost Manufacturing Technology to a Turbine Gas Generator
Authors: Due H. F. , Buchanan E. 
Published: April 2015

The Low Cost Gas Generator (LCGG) program addresses the task of designing and demonstrating gas generator components with low cost as the primary objective. The components are sized to provide a turbojet engine configuration in the 9000-N thrust class (SLS, 288 K) and are applicable to a turbofan engine. By demonstrating these components in the actual engine environment, as a turbojet, a solid base will be established for transitioning this technology into engineering development as specific firm mission requirements become available. The program is sponsored by the U.S. Air Force Aero Propulsion Laboratory and consists of three phases covering a 39-month period as follows:
Phase I – Preliminary Design (7 months)
Phase II – Component Detail Design, Fabrication & Testing
Phase III – Gas Generator Design, Fabrication & Testing (1 2 months).
The Phase I portion of the program was completed in December 1976 and the results are discussed in this paper. The Phase I, preliminary design, consisted of performing cycle analysis, aero-thermo analyses, mechanical design, and manufacturing analyses to determine the best turbine engine configuration which satisfied the program objectives. The results of Phase I indicate that a turbojet in the 9000-N thrust class can be produced for approximately 2.4 $/N SLS thrust (1976 dollars) by making maximum use of casting technology and mechanical design simplicity. The SFC is 10 to 20 percent higher than existing engines in the same thrust class; however, the thrust to weight is comparable or better than engines used for RPV, missile, or drone applications.
Draft Genome Sequence of Bacillus amyloliquefaciens AP183 with Antibacterial Activity against Methicillin-Resistant Staphylococcus aureus
Authors: Nasrin Shamima , Hossain Mohammad J. , Liles Mark R. 
Published: April 2015

ABSTRACT

Bacillus amyloliquefaciens
AP183 expresses secondary metabolites that inhibit the growth of methicillin-resistant
Staphylococcus aureus
(MRSA). Here, we present a ~3.99-Mbp draft genome sequence of AP183 with the aims of providing insights into the genomic basis of its antibacterial mechanisms and exploring its potential use in preventing MRSA skin colonization.
Complete Genome Sequence of Teviot Paramyxovirus, a Novel Rubulavirus Isolated from Fruit Bats in Australia
Authors: Burroughs Amy L. , Tachedjian Mary , Crameri Gary , Durr Peter A. , Marsh Glenn A. , Wang Lin-Fa 
Published: April 2015

ABSTRACT
The causative agents of a number of emerging zoonotic diseases have been identified as paramyxoviruses originating in bats. We report here the complete genome sequence of two Teviot paramyxoviruses, novel rubulaviruses isolated from urine samples collected from pteropid bats in Australia. The zoonotic potential of Teviot paramyxovirus is undetermined.
Full-Genome Sequences of Severe Fever with Thrombocytopenia Syndrome Virus, Isolated from South Korea in 2014
Authors: Yun Mi-ran , Park Sun-Whan , Kwon TaeSoo , Lee SangHyun , Yoo Won Gi , Choi WooYoung , Lee Won-Ja , Kim Dae-Won 
Published: April 2015

ABSTRACT
Here, we present the full-length genome sequencing of severe fever with thrombocytopenia syndrome (SFTS) virus, isolated from South Korea in 2014. The five Korean strains were compared by phylogenetic analysis with full SFTS genome sequences of two neighboring nations, China and Japan.
Complete Genome Sequence of Paenibacillus polymyxa CF05, a Strain of Plant Growth-Promoting Rhizobacterium with Elicitation of Induced Systemic Resistance
Authors: Lei Mengying , Lu Peng , Jin Liping , Wang Yan , Qin Jialing , Xu Xi , Zhang Liqin , Wang Yongjun 
Published: April 2015

ABSTRACT

Paenibacillus polymyxa
CF05 is a Gram-positive rod-shaped bacterium isolated from the interior of an ancient tree,
Cryptomeria fortunei
, in China. This bacterium displays potent biocontrol effects against certain soil-borne diseases and the elicitation of induced systemic resistance in tomatoes. Here, we report the complete genome sequence of
P. polymyxa
CF05.
Comparative Genomics of the Mucoid and Nonmucoid Strains of Streptococcus pyogenes, Isolated from the Same Patient with Streptococcal Meningitis
Authors: Yoshida Haruno , Ishigaki Yasuhito , Takizawa Asako , Moro Kunihiko , Kishi Yuki , Takahashi Takashi , Matsui Hidenori 
Published: April 2015

ABSTRACT

Mucoid (MTB313) and nonmucoid (MTB314) strains of group A streptococcus
emm
type 1 were simultaneously isolated from a single patient suffering from streptococcal meningitis. Whole-genome sequencing revealed that MTB313 carried a nucleotide substitution within
rocA
, which generated an amber termination codon.
Complete Genome Sequence of the
Alfalfa latent virus
Authors: Nemchinov Lev G. , Shao Jonathan , Postnikova Olga A. 
Published: April 2015

ABSTRACT

The first complete genome sequence of the
Alfalfa latent carlavirus
(ALV) was obtained by primer walking and Illumina RNA sequencing. The virus differs substantially from the Czech ALV isolate and the
Pea streak virus
isolate from Wisconsin. The absence of a clear nucleic acid-binding protein indicates ALV divergence from other carlaviruses.
Draft Genome Sequence of
Dactylonectria macrodidyma
, a Plant-Pathogenic Fungus in the
Nectriaceae
Authors: Malapi-Wight Martha , Salgado-Salazar Catalina , Demers Jill , Veltri Daniel , Crouch Jo Anne 
Published: April 2015

ABSTRACT

Dactylonectria macrodidyma
is part of the
Nectriaceae
, a family containing important plant pathogens. This species possesses the ability to induce disease on grapevine, avocado, and olive. Here, we report the first draft genome of
D. macrodidyma
isolate JAC15-245. The assembled genome was 58 Mbp and contained an estimated 16,454 genes.
Whole-Genome Sequencing and Annotation of Bacillus safensis RIT372 and Pseudomonas oryzihabitans RIT370 from
Capsicum annuum
(Bird's Eye Chili) and
Capsicum chinense
(Yellow Lantern Chili), Respectively
Authors: Gan Huan You , Gan Han Ming , Savka Michael A. , Triassi Alexander J. , Wheatley Matthew S. , Naqvi Kubra F. , Foxhall Taylor E. , Anauo Michael J. , Baldwin Mariah L. , Burkhardt Russell N. , O’Bryon Isabelle G. , Dailey Lucas K. , Busairi Nurfatini Idayu , Keith Robert C. , Khair Megat Hazmah Megat Mazhar , Rasul Muhammad Zamir Mohd , Rosdi Nur Aiman Mohd , Mountzouros James R. , Rhoads Aleigha C. , Selochan Melissa A. , Tautanov Timur B. , Polter Steven J. , Marks Kayla D. , Caraballo Alexander A. , Hudson André O. 
Published: April 2015

ABSTRACT

Here, we report the genome sequences of
Bacillus safensis
RIT372 and
Pseudomonas oryzihabitans
RIT370 from
Capsicum
spp. Annotation revealed gene clusters for the synthesis of bacilysin, lichensin, and bacillibactin and sporulation killing factor (
skfA
) in
Bacillus safensis
RIT372 and turnerbactin and carotenoid in
Pseudomonas oryzihabitans
RIT370.
Draft Genomes of Two Sordariomycete Fungi That Produce Novel Secondary Metabolites
Authors: Stamps Blake W. , Du Lin , Mitchell Carter A. , Cichecwicz Robert H. , Stevenson Bradley S. 
Published: April 2015

ABSTRACT

The genomes of two fungi isolated from soil (MEA-2) and sediment (SUP5-1) were sequenced. Both were members of the order
Hypocreales
, closely related to
Tolypocladium inflatum
, and capable of producing novel secondary metabolites. The draft genomes enabled the characterization of key biosynthetic pathways.
Complete Genome Sequence of Canine Papillomavirus Virus Type 12
Authors: Zhou Dan , Luff Jennifer , Paul Siddhartha , Alkhilaiwi Faris , Usuda Yukari , Wang Naidong , Affolter Verena , Moore Peter , Schlegel Richard , Yuan Hang 
Published: April 2015

ABSTRACT

Papillomaviruses, of the family
Papillomaviridae
, are epitheliotropic, nonenveloped, circular, double-stranded DNA viruses that contribute to benign and malignant tumors in humans and animals. We report here the whole-genome sequence of canine papillomavirus type 12, found at a pigmented plaque located on the skin of a mixed-breed bloodhound.
Draft Genome Sequence of the Biofilm-Forming Stenotrophomonas maltophilia Strain 53
Authors: Akbar Sirwan , Rout Simon P. , Humphreys Paul N. 
Published: April 2015

ABSTRACT

A clinical strain of
Stenotrophomonas maltophilia
(designated strain 53) was obtained, and a whole-genome sequence was generated. The subsequent draft whole-genome sequence demonstrated the presence of a number of genes encoding for proteins involved in resistance to a number of antimicrobial therapies.
Sexual function in women undergoing surgery for deep infiltrating endometriosis: a comparison with healthy women
Authors: Di Donato Nadine , Montanari Giulia , Benfenati Arianna , Monti Giorgia , Leonardi Deborah , Bertoldo Valentina , Facchini Chiara , Raimondo Diego , Villa Gioia , Seracchioli Renato 
Published: April 2015

BackgroundEndometriosis is a chronic and progressive condition of women of reproductive age. It is strongly associated with significant impairment of sexual function.AimTo objectively evaluate the impact of laparoscopic excision of endometriosis on sexual function in patients with deep infiltrating endometriosis (DIE) compared to healthy women.Setting and designProspective study, including 250 patients with a diagnosis of DIE scheduled for laparoscopic surgery and 250 healthy women.MethodsA sexual activity questionnaire, SHOW-Q (Sexual Health Outcomes in Women Questionnaire), was used to collect data pertaining to women's satisfaction, orgasm, desire and pelvic problem interference with sexual function. Women with DIE underwent complete excision of endometriotic lesions. All participants were asked to complete the SHOW-Q questionnaire before and after surgery.ResultsSHOW-Q scores in the endometriosis group before and 6 months after surgery were compared with the healthy group scores. A significant improvement was found between pre- and post-treatment in the scores of the satisfaction scale, desire scale and pelvic problem interference scale of SHOW-Q. The distribution of post-surgery SHOW-Q scores was comparable to healthy women's scores apart from the orgasm scale score, which was unchanged in the post-surgery group.ConclusionsThe surgical approach to treatment has a positive impact not only on organ impairment but also on sexual function in women affected by DIE.
Sedimentological evolution of Sele Formation deep-marine depositional systems of the Central North Sea
Authors: Eldrett James , Tripsanas Efthymios , Davis Christopher , McKie Tom , Vieira Manuel , Osterloff Peter , Sandison Tom 
Published: April 2015

Abstract

The Paleocene–Eocene-aged Sele Formation is developed across the basinal region of the Central North Sea. The section comprises a number of deep-marine fan systems that expanded and contracted across the basin floor in response to relative sea-level changes on the basin margin and fluctuating sediment yield off the Scottish landmass modulated by climate and hinterland uplift. Persistent sediment entry points to the basin resulted in the development of discrete axial and transverse fan fairways with a geometry dictated by an irregular bathymetry sculpted by differential compaction across Mesozoic faults, halokinesis and antecedent fan systems. A high-resolution biostratigraphic framework has allowed the evolution of fan-dispersal systems in response to these effects to be tracked across the basin within four genetic sequences. The proximal parts of the fans comprised channel complexes of low sinuosity, high lateral offset, and low aggradation. The development of these systems in a bathymetrically confined corridor of the Central Graben (
c.
65 km wide), combined with high sediment supply, resulted in the eventual burial of any underlying relief. The behaviour of sand-rich reservoirs in this region is dominated by the permeability contrast between high-quality channel fairways and more heterolithic overbank regions, with the potential for early water breakthrough and aquifer coning in the channel fairways, and unswept volumes in overbank locations. Compartmentalization of compensationally stacked channel bodies occurs locally, with stratigraphic trapping caused by lateral channel pinch-outs, channel-base debrites, mud-rich drapes and abandonment fines. Towards the southern part of Quadrant 22, approximately 150 km down-palaeoflow, the systems became less confined and in this region are dominated by channel–lobe complexes, which continued to interact with an irregular bathymetry controlled by antecedent fans, mass-transport complexes and halokinesis in the form of rising salt diapirs. Reservoirs in this region are inherently stratigraphically compartmentalized by their heterolithic lithology and compensational stacking of lobes, and further complicated by structuration and instability induced by the diapiric or basement structures needed to generate a trapping structure in these settings.
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K–AKT Signaling at Endosomes
Authors: Li Chew Chen , Lunardi Andrea , Gulluni Federico , Ruan Daniel T. , Chen Ming , Salmena Leonardo , Nishino Michiya , Papa Antonella , Ng Christopher , Fung Jacqueline , Clohessy John G. , Sasaki Junko , Sasaki Takehiko , Bronson Roderick T. , Hirsch Emilio , Pandolfi Pier Paolo 
Published: April 2015

Abstract
The phosphatases PTEN and INPP4B have been proposed to act as tumor suppressors by antagonizing PI3K–AKT signaling and are frequently dysregulated in human cancer. Although PTEN has been extensively studied, little is known about the underlying mechanisms by which INPP4B exerts its tumor-suppressive function and its role in tumorigenesis in vivo. Here, we show that a partial or complete loss of Inpp4b morphs benign thyroid adenoma lesions in Pten heterozygous mice into lethal and metastatic follicular-like thyroid cancer (FTC). Importantly, analyses of human thyroid cancer cell lines and specimens reveal INPP4B downregulation in FTC. Mechanistically, we find that INPP4B, but not PTEN, is enriched in the early endosomes of thyroid cancer cells, where it selectively inhibits AKT2 activation and in turn tumor proliferation and anchorage-independent growth. We therefore identify INPP4B as a novel tumor suppressor in FTC oncogenesis and metastasis through localized regulation of the PI3K–AKT pathway at the endosomes.
Significance: Although both PTEN and INPP4B can inhibit PI3K–AKT signaling through their lipid phosphatase activities, here we demonstrate lack of an epistatic relationship between the two tumor suppressors. Instead, the qualitative regulation of PI3K–AKT2 signaling by INPP4B provides a mechanism for their cooperation in suppressing thyroid tumorigenesis and metastasis. Cancer Discov; 5(7); 740–51. ©2015 AACR.
See related commentary by Vo and Fruman, p. 697.
See related article by Kofuji and colleagues, p. 730.
This article is highlighted in the In This Issue feature, p. 681
Common Sequence Variants Associated With Coronary Artery Disease Correlate With the Extent of Coronary Atherosclerosis
Authors: Bjornsson Eythor , Gudbjartsson Daniel F. , Helgadottir Anna , Gudnason Thorarinn , Gudbjartsson Tomas , Eyjolfsson Kristjan , Patel Riyaz S. , Ghasemzadeh Nima , Thorleifsson Gudmar , Quyyumi Arshed A. , Thorsteinsdottir Unnur , Thorgeirsson Gudmundur , Stefansson Kari 
Published: April 2015

Objective—
Single-nucleotide polymorphisms predisposing to coronary artery disease (CAD) have been shown to predict cardiovascular risk in healthy individuals when combined into a genetic risk score (GRS). We examined whether the cumulative burden of known genetic risk variants associated with risk of CAD influences the development and progression of coronary atherosclerosis.

Approach and Results—

We investigated the combined effects of all known CAD variants in a cross-sectional study of 8622 Icelandic patients with angiographically significant CAD (≥50% diameter stenosis). We constructed a GRS based on 50 CAD variants and tested for association with the number of diseased coronary arteries on angiography. In models adjusted for traditional cardiovascular risk factors, the GRS associated significantly with CAD extent (difference per SD increase in GRS, 0.076;
P
=7.3×10
−17
). When compared with the bottom GRS quintile, patients in the top GRS quintile were roughly 1.67× more likely to have multivessel disease (odds ratio, 1.67; 95% confidence interval, 1.45–1.94). The GRS significantly improved prediction of multivessel disease over traditional cardiovascular risk factors (χ
2
likelihood ratio 48.1;
P
<0.0001) and modestly improved discrimination, as estimated by the
C
-statistic (without GRS versus with GRS, 64.0% versus 64.8%) and the integrated discrimination improvement (0.52%). Furthermore, the GRS associated with an earlier age at diagnosis of angiographic CAD. These findings were replicated in an independent sample from the Emory Biobank study (n=1853).

Conclusions—
When combined into a single GRS, known genetic risk variants for CAD contribute significantly to the extent of coronary atherosclerosis in patients with significant angiographic disease.
Cardiomyopathy and Worsened Ischemic Heart Failure in SM22-α Cre-Mediated Neuropilin-1 Null Mice
Authors: Wang Ying , Cao Ying , Yamada Satsuki , Thirunavukkarasu Mahesh , Nin Veronica , Joshi Mandip , Rishi Muhammed T. , Bhattacharya Santanu , Camacho-Pereira Juliana , Sharma Anil K. , Shameer Khader , Kocher Jean-Pierre A. , Sanchez Juan A. , Wang Enfeng , Hoeppner Luke H. , Dutta Shamit K. , Leof Edward B. , Shah Vijay , Claffey Kevin P. , Chini Eduardo N. , Simons Michael , Terzic Andre , Maulik Nilanjana , Mukhopadhyay Debabrata 
Published: April 2015

Objective—
Neuropilin-1 (NRP-1) is a multidomain membrane receptor involved in angiogenesis and development of neuronal circuits, however, the role of NRP-1 in cardiovascular pathophysiology remains elusive.

Approach and Results—

In this study, we first observed that deletion of NRP-1 induced peroxisome proliferator–activated receptor γ coactivator 1α in cardiomyocytes and vascular smooth muscle cells, which was accompanied by dysregulated cardiac mitochondrial accumulation and induction of cardiac hypertrophy- and stress-related markers. To investigate the role of NRP-1 in vivo, we generated mice lacking
Nrp-1
in cardiomyocytes and vascular smooth muscle cells (SM22-α-
Nrp-1
KO), which exhibited decreased survival rates, developed cardiomyopathy, and aggravated ischemia-induced heart failure. Mechanistically, we found that NRP-1 specifically controls peroxisome proliferator–activated receptor γ coactivator 1 α and peroxisome proliferator–activated receptor γ in cardiomyocytes through crosstalk with Notch1 and Smad2 signaling pathways, respectively. Moreover, SM22-α-
Nrp-1
KO mice exhibited impaired physical activities and altered metabolite levels in serum, liver, and adipose tissues, as demonstrated by global metabolic profiling analysis.

Conclusions—
Our findings provide new insights into the cardioprotective role of NRP-1 and its influence on global metabolism.