bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pituitary metastases from papillary carcinoma of thyroid: a case report and literature review
Authors: Chikani Viral , Lambie Duncan , Russell Anthony 
Published: August 2013

SummaryMetastases to the pituitary gland are an uncommon complication of thyroid cancer. They resemble pituitary neoplasms posing a diagnostic challenge. We present a case of an aggressive non-radioiodine avid papillary thyroid cancer with recurrent pituitary metastases and a review of the literature. A 70-year-old woman with a history of papillary thyroid cancer and bony metastases presented with symptoms of hypoadrenalism and peripheral vision loss. Magnetic resonance imaging showed a large pituitary mass impinging on the optic chiasm. She underwent transsphenoidal resection followed by131I ablation. Post-therapy scintigraphy showed no iodine uptake in the sellar region or bony metastases. Histology of the pituitary mass confirmed metastatic papillary thyroid cancer. Fifteen months later, she had a recurrence of pituitary metastases affecting her vision. This was resected and followed with external beam radiotherapy. Over 2 years, the pituitary metastases increased in size and required two further operations. Radioactive iodine was not considered due to poor response in the past. Progressively, she developed a left-sided III and IV cranial nerve palsy and permanent bitemporal hemianopia. There was a rapid decline in the patient's health with further imaging revealing new lung and bony metastases, and she eventually died 8 months later. To our knowledge, this is the first case of pituitary metastases from a radioiodine-resistant papillary thyroid cancer. Radioiodine-resistant metastatic thyroid cancer may exhibit rapid aggressive growth and remain poorly responsive to the currently available treatment.Learning pointsDifferentiated thyroid cancer (DTC) has an excellent prognosis with <5% of the cases presenting with distant metastases, usually to lung and bone.Metastasis to the pituitary is a rare complication of DTC.The diagnosis of pituitary insufficiency secondary to pituitary metastases from DTC may be delayed due to the non-specific systemic symptoms of underlying malignancy and TSH suppression therapy for thyroid cancer.The imaging characteristics of metastases to the pituitary may be similar to non-functioning pituitary adenoma.Radioiodine refractory metastatic thyroid cancer has significantly lower survival rates compared with radioactive iodine-avid metastases due to limited therapeutic options.
Determination of Fracture Conductivity in Tight Formations With Non-Darcy Flow Behavior
Authors: Zhang Feng , Yang Daoyong 
Published: August 2013

Summary
In this paper, a mathematical model has been developed and successfully applied to accurately determine the fracture conductivity in tight formations with non-Darcy flow behavior. A new non-Darcy flow number is first defined to account for the effect of characteristic length in a hydraulic fracture. A semianalytical method is then applied to solve the newly formulated mathematical model by discretizing the fracture into small segments, assuming that there exists unsteady flow between the adjacent segments. The newly developed model has been validated by simplifying it to the traditional Forchheimer (i.e., non-Darcy) model and by performing numerical simulation with a reservoir simulator as well. The pressure response and its corresponding derivative type curves have been reproduced to examine non-Darcy flow behavior under different fracture conductivities. Both relative minimum permeability and characteristic length are found to impose a negative effect on the fracture conductivity. Compared with relative minimum permeability, characteristic length is a strong function dominating the non-Darcy flow behavior in the fractures. It is obvious that the fracture conductivity can be accurately determined when non-Darcy flow behavior in the fracture network is taken into account.
Constraints on Simultaneous Growth of Hydraulic Fractures From Multiple Perforation Clusters in Horizontal Wells
Authors: Bunger A.P.. P. , Jeffrey R.G.. G. , Zhang X.. 
Published: August 2013

Summary
In spite of the fact that multistage hydraulic fracturing from horizontal wells is the fastest growing and arguably the most economically important application for well stimulation, numerous fundamental questions remain that are relevant to determining how long to make each isolated interval and how many perforation clusters to place within each interval. This paper provides new insights into this problem by predicting how many hydraulic fractures can be expected to grow simultaneously from multiple perforation clusters pressurized by a single injection stage. These predictions are obtained from a coupled mathematical model that includes the contributions of fluid flow, rock breakage, and pressure loss through the perforations to the total power requirements for the growth of arrays of multiple hydraulic fractures. For typical shale-gas stimulations, radial hydraulic fractures are predicted to grow from all perforation clusters, with progressive reduction in the number of hydraulic fractures, thereby maintaining a ratio of the radius to the spacing that is a small amount less than unity. If the hydraulic fractures are contained to a height H, then multiple Perkins-Kern-Nordgren (PKN) -like hydraulic fractures are predicted to continue growing, with the length of each hydraulic fracture increasing throughout the injection and with a spacing that is approximately 1.5 H when perforation losses are strong and approximately 2.5 H when perforation losses are negligible. These geometric predictions are consistent with previously published observations based on microseismicity associated with stimulations in the Barnett shale.
Medication Reconciliation and Therapy Management in Dialysis-Dependent Patients
Authors: Pai Amy Barton , Cardone Katie E. , Manley Harold J. , St. Peter Wendy L. , Shaffer Rachel , Somers Michael , Mehrotra Rajnish 
Published: August 2013

SummaryPatients with ESRD undergoing dialysis have highly complex medication regimens and disproportionately higher total cost of care compared with the general Medicare population. As shown by several studies, dialysis-dependent patients are at especially high risk for medication-related problems. Providing medication reconciliation and therapy management services is critically important to avoid costs associated with medication-related problems, such as adverse drug events and hospitalizations in the ESRD population. The Medicare Modernization Act of 2003 included an unfunded mandate stipulating that medication therapy management be offered to high-risk patients enrolled in Medicare Part D. Medication management services are distinct from the dispensing of medications and involve a complete medication review for all disease states. The dialysis facility is a logical coordination center for medication management services, like medication therapy management, and it is likely the first health care facility that a patient will present to after a care transition. A dedicated and adequately trained clinician, such as a pharmacist, is needed to provide consistent, high-quality medication management services. Medication reconciliation and medication management services that could consistently and systematically identify and resolve medication-related problems would be likely to improve ESRD patient outcomes and reduce total cost of care. Herein, this work provides a review of available evidence and recommendations for optimal delivery of medication management services to ESRD patients in a dialysis facility-centered model.
A propos de Santa Maria de Besalù - tentative de restitution architectonique
Authors: Mazure Anne 
Published: August 2013

This is a methodical and more profound study of ail the texts and archives, (unfortunately too rare), relating to Sainte Marie de Besalû. H makes a ualuable contribution to research on the past ofthis collegiate church, of wich only a part of the apse remains as witness to its former splendour. The writer also backs up her arguments by means of an enquiry carried out among elderly résidents of Besalû who had from their parents information or old photo- graphs. These allow her to appreciate the different stages of construction and then destruction of the church.
Different ground plans, photographs of 1916, old lithographs, enable us to follow the author as she deuelops her conclusions with the aid of a set of diagrams.
To conclude, this study : furnishes new documents, proposes an improved reading of texts and old photographs which had not been analysed with sufficient care.
It obliges a renewed study of the church on a fresh basis by showing that the nave pre-dates the apse. In particu- lar, it shows that digs are indispensable if the nave is to be located.
Fragments de plafond peint du XIVe siècle au Puy (Haute-Loire)
Authors: Peyron Jacques , Robert Annick 
Published: August 2013

Le musée Crozatier, au Puy-en-Velay, a acquis les vestiges du décor provenant d'un hôtel de la rue Cardinal de Po- lignac. Ces fragments sont le délaissé provenant de l'arrachement qui a précédé la vente de l'immeuble, du décor peint réalisé entre 1361 et 1382. La disposition rappelait sans doute celle visible dans le donjon du château de Poinsac, voisin du Puy.
Comme généralement à cette époque les thèmes regroupent des blasons, des animaux fantastiques et quelques personnages parmi lesquels on peut reconnaître un joueur de chalemie, un buveur et un acrobate. Bien qu'ils soient séparés de leur contexte, ces vestiges peuvent être rattachés à l'ensemble des peintures médiévales de plafonds peints languedociens.
La Vaunage du IIIe siècle au milieu du XIIe siècle. Habitat et occupation des sols
Authors: Parodi Anne , Raynaud Claude , Roger Jean-Marc 
Published: August 2013

Intense archaeological activity - prospecting and excavations - has been carried oui in récent years near Nîmes, in the Vaunage subsidence basin. As abundant documentary evidence is also provided by the capitulary of the Nîmes cathedral chapter, comparison of the informations given by field archaeology and written sources, as well as by a morphological analysis of villages and microtoponymy, allows a precise description of the organization of this rural area.
In the course of the long period ofLate Antiquity and Early Middle Ages, a dynamic study of the population reveals the successive changes undergone by the Languedocian rural society while passing from the Gallo-Roman to the Medieval civilization. However important these changes may be, the investigation also emphasizes the importance of the legacy transmitted by Antiquity as far as land occupation and the perpetuation of the ancient grouped habitat are concerned.
Restitution de la demeure médiévale montpelliéraine
Authors: Sournia Bernard , Vayssettes J.-L. 
Published: August 2013

Essai de restitution et de classification typologique de l'habitat urbain à Montpellier, des origines à la fin du Moyen Age. Les solutions en présence paraissent toutes dérivées des contraintes techniques liées à la rareté des bois de charpente, ceux-ci étant remplacés par des murs de refend tenant lieu de fermes et/ou de pannes faîtières.
L'analyse s'attarde sur l'étude des maisons de grand format et en reconstitue l'organisation générale à partir des rares vestiges archéologiques subsistants et d'informations fournies par des textes tardifs, notamment les expertises après- vente du 17e siècle, grâce auxquels se dégagent très nettement les éléments constitutifs de ces demeures : le « porche couvert », sorte de préau, prolongement à couvert de la cour ; l'escalier extérieur, à volées droites, la « salle », à laquelle il conduit, les coursières ou « courroirs » de distribution ; la tour, etc.. A la lumière de ces analyses est proposée une nouvelle interprétation du motif, très apprécié localement à l'époque moderne, de la cage d'escalier à claire-voie, survivance très probable du principe médiéval du « porche couvert ». Des essais de cartographie montrent comment les diverses variétés d'habitat se répartissent dans la ville médiévale par quartiers de faciès très contrasté.
La vulgarisation du principe de l'escalier en vis et le motif de la tourelle hors-œuvre qui le contient, introduisent au 1 5e s. un facteur révolutionnaire dans le système établi, en brisant l'interdépendance des niveaux jusque-là de règle.
Abbayes laïques et domenjadures : l’habitat aristocratique en haut Béarn
Authors: Berdoy Anne 
Published: August 2013

In the context of a study of medieval aristocracy in a sector of the western Pyrenees — the mountainous
zone of the Béarn — the data collected from written sources and fieldwork allow us to better understand of the role of the nobility in a society known for the importance of the community. In fact, the aristocratic presence was not as late or superficial as it appeared until now. A first generation, represented in each village by secular abbots, was joined nearly everywhere by lords of the feudal period. Their rights, as can
be determined based on often late or incomplete documentation, was not always negligible: on the other hand, it seems that they were rapidly eliminated by the rising power of village communities.
Abnormal Expression of CD20 on IgG4 Plasma Cells Associated With IgG4-Related Lymphadenopathy
Authors: Grimm Kate E. , Bakke Antony , O'Malley Dennis P. 
Published: August 2013

Context.—Immunoglobulin G4 (IgG4)–related disease is a recently described entity that presents as mass-forming lesions in soft tissue, exocrine glands, and in lymph nodes as IgG4-related lymphadenopathy. The underlying pathologic mechanism of IgG4-related disease is unclear; however, rituximab (an anti-CD20 monoclonal antibody) has been shown to have clinical efficacy.Objective.—To look for the presence or absence of CD20 on the IgG4-expressing plasma cells in IgG4-related lymphadenopathy.Design.—Twelve flow cytometry cases were identified through a retrospective review from the authors' institutions files. Cases were selected by the presence of a lymph node biopsy specimen with increased IgG4 plasma cells by immunohistochemistry and a histologic diagnosis compatible with IgG4-related lymphadenopathy.Results.—We report dim CD20 expression on plasma cells in all cases for which a plasma cell population was clearly identified by flow cytometry. These cases were from patients with lymph node biopsy specimens that met published criteria for IgG4-related lymphadenopathy.Conclusions.—This finding may be one potential explanation for the clinical efficacy of rituximab in IgG4-related disease.
Quantitative assessment of the contribution of sodium‐dependent taurocholate co‐transporting polypeptide (NTCP) to the hepatic uptake of rosuvastatin, pitavastatin and fluvastatin
Authors: Bi Yi‐an , Qiu Xi , Rotter Charles J. , Kimoto Emi , Piotrowski Mary , Varma Manthena V. , EI‐Kattan Ayman F. , Lai Yurong 
Published: August 2013

ABSTRACTHepatic uptake transport is often the rate‐determining step in the systemic clearance of drugs. The ability to predict uptake clearance and to determine the contribution of individual transporters to overall hepatic uptake is therefore critical in assessing the potential pharmacokinetic and pharmacodynamic variability associated with drug–drug interactions and pharmacogenetics. The present study revisited the interaction of statin drugs, including pitavastatin, fluvastatin and rosuvastatin, with the sodium‐dependent taurocholate co‐transporting polypeptide (NTCP) using gene transfected cell models. In addition, the uptake clearance and the contribution of NTCP to the overall hepatic uptake were assessed using in vitro hepatocyte models. Then NTCP protein expression was measured by a targeted proteomics transporter quantification method to confirm the presence and stability of NTCP expression in suspended and cultured hepatocyte models. It was concluded that NTCP‐mediated uptake contributed significantly to active hepatic uptake in hepatocyte models for all three statins. However, the contribution of NTCP‐mediated uptake to the overall active hepatic uptake was compound‐dependent and varied from about 24% to 45%. Understanding the contribution of individual transporter proteins to the overall hepatic uptake and its functional variability when other active hepatic uptake pathways are interrupted could improve the current prediction practice used to assess the pharmacokinetic variability due to drug–drug interactions, pharmacogenetics and physiopathological conditions in humans. Copyright © 2013 John Wiley & Sons, Ltd.
ChemInform Abstract: Synchrotron Powder Study of Na3V(PO3)3N.
Authors: Kim Minwoong , Kim Seung‐Joo 
Published: August 2013

AbstractPolycrystalline Na3V(PO3)3N is prepared by thermal nitridation of a mixture of NaPO3 and V2O5 (alumina crucible, flowing anhydrous NH3, 1.
ChemInform Abstract: Oxide Fluoride Sulfides of the Lanthanoids with the Formula M6O2F8S3 (M: La—Nd, Sm, Gd).
Authors: Grossholz Hagen , Zimmermann Dirk D. , Janka Oliver , Schleid Thomas 
Published: August 2013

AbstractThe title compounds are synthesized from mixtures of Ln (Ln: La—Nd, Sm, Gd), LnF3, Ln2O3 (resp.
ChemInform Abstract: Synthesis of Divalent Europium Borate via in situ Reductive Techniques.
Authors: Polinski Matthew J. , Cross Justin N. , Villa Eric M. , Lin Jian , Alekseev Evgeny V. , Depmeier Wulf , Albrecht‐Schmitt Thomas E. 
Published: August 2013

AbstractEu[B8O11(OH)4], is prepared by two in situ reductive methodologies.
ChemInform Abstract: Asymmetric Rhodium‐Catalyzed 1,4‐ and 1,2‐Additions of Arylboronic Acids to Activated Ketones in Water at Room Temperature Using a Mixed Sulfur‐Olefin Ligand.
Authors: Khiar Noureddine , Valdivia Victoria , Salvador Alvaro , Chelouan Ahmed , Alcudia Ana , Fernandez Inmaculada 
Published: August 2013

AbstractAn efficient micellar catalytic approach for the 1,4‐addition of boronic acids to cyclic ketones (I) and lactone (IV), which permits the preparation of chiral ketones (III) and ester (V), resp., in high enantioselectivities is described.
ChemInform Abstract: New Approach to Oximes Through Reduction of Nitro Compounds Enabled by Visible Light Photoredox Catalysis.
Authors: Cai Shunyou , Zhang Shaolong , Zhao Yaohong , Wang Zhigang 
Published: August 2013

AbstractNitro compounds are smoothly reduced to their corresponding oximes under visible light irradiation in the presence of Huenig′s base, magnesium perchlorate, and a photocatalyst.
ChemInform Abstract: An Efficient Synthesis of Enantiomerically Pure trans‐N1,N2‐Dimethylcyclohexane‐1,2‐diamine.
Authors: Shen Yan‐Hong , Ye Qing , Hou Shao‐Gang , Wang Qun 
Published: August 2013

AbstractA convenient and efficient process for the synthesis of racemic trans‐cyclohexanediamine (V) and its kinetic resolution using tartaric acid is described.
ChemInform Abstract: A Catalyst‐Free, One‐Pot Three‐Component Aminomethylation of α‐Substituted Nitroacetates: Theoretical and Experimental Studies into the Rate‐Accelerating Effects of the Solvent Methanol.
Authors: Ji Cong‐Bin , Cao Zhong‐Yan , Wang Xin , Wu De‐Yin , Zhou Jian 
Published: August 2013

AbstractThe reaction represents the first example of the aminomethylation of both α‐alkyl and α‐aryl‐substituted nitroacetates under catalyst‐free conditions.
ChemInform Abstract: Ring Rearrangement Metathesis of 2‐Allylbicyclo[2.2.2]octenes: A Short Entry to cis‐Hydrindenols from 2‐Methoxyphenols.
Authors: Tsao Kuo‐Wei , Devendar Badugu , Liao Chun‐Chen 
Published: August 2013

AbstractDiels—Alder adducts of masked o‐benzoquinones are demethoxylated and allylated to serve as precursors for a highly efficient synthesis of the desired structural unit.
ChemInform Abstract: Synthesis of 2,3‐Diarylfluorenones by Domino “Twofold Heck/Electrocyclization/Dehydrogenation” Reactions of 2,3‐Dibromoindenone.
Authors: Akrawi Omer A. , Khan Afsar , Hussain Munawar , Mohammed Hamid H. , Villinger Alexander , Langer Peter 
Published: August 2013

AbstractOptimized reaction conditions are developed for the construction of the important scaffold.
ChemInform Abstract: A Novel Method for the Synthesis of 3,4‐Disubstitutedpyrrole‐2,5‐dicarboxylates from Hydrazones Derived from α‐Diazo Esters.
Authors: Yasui Eiko , Wada Masao , Nagumo Shinji , Takamura Norio 
Published: August 2013

AbstractThe reactions of the compounds (If) and (Ij) give complex mixtures.
ChemInform Abstract: General and Efficient Synthesis of 2,3‐Unsubstituted Indoles Catalyzed by Acidic Mesoporous Molecular Sieves.
Authors: Sun Nan , Hong Lingfen , Huang Fang , Ren Hong , Mo Weimin , Hu Baoxiang , Shen Zhenlu , Hu Xinquan 
Published: August 2013

AbstractThe silica‐supported sulfuric acid MCM‐41‐SO3H is an efficient and reusable catalyst for the preparation of N‐benzylindoles by an intramolecular cyclization of N‐benzyl‐2‐anilinoacetals.
ChemInform Abstract: Intramolecular Larock Indole Synthesis: Preparation of 3,4‐Fused Tricyclic Indoles and Total Synthesis of Fargesine.
Authors: Shan Dong , Gao Yan , Jia Yanxing 
Published: August 2013

AbstractA variety of common, medium, and large ring fused tricyclic indoles including the fargesine precursor (XIV) are prepared from o‐iodoaniline substrates under optimized conditions A).
ChemInform Abstract: Cyclocondensation of Arylhydrazines with 1,3‐Bis(het)arylmonothio‐1,3‐diketones and 1,3‐Bis(het)aryl‐3‐(methylthio)‐2‐propenones: Synthesis of 1‐Aryl‐3,5‐bis(het)arylpyrazoles with Complementary Regioselectivity.
Authors: Kumar S. Vijay , Yadav Santosh K. , Raghava B. , Saraiah B. , Ila H. , Rangappa K. S. , Hazra Arpan 
Published: August 2013

AbstractThe unsymmetrical title compounds are selectively synthesized with complementary regioselectivity by using neutral or basic conditions leading to the pyrazole (V) or (VIII), respectively.
ChemInform Abstract: Radical‐Mediated Diamination of Alkenes with Phenylhydrazine and Azodicarboxylates: Highly Diastereoselective Synthesis of trans‐Diamines from Cycloalkenes.
Authors: Zhu Ming‐Kui , Chen Yu‐Chen , Loh Teck‐Peng 
Published: August 2013

AbstractDifferent substituted pyrazole derivatives can be obtained by this three‐component one‐pot procedure starting from the corresponding β,γ‐unsaturated ketones.
ChemInform Abstract: Metal‐Free Aerobic Oxidation of Benzazole Derivatives.
Authors: Dos Santos Aurelie , El Kaim Laurent , Grimaud Laurence 
Published: August 2013

AbstractA comparison of palladium‐catalyzed and metal‐free aerobic oxidations of benzimidazoles (I), benzothiazoles (III), and thiazole (V) is given.
ChemInform Abstract: Synthesis and Antibacterial Activity of 3‐(Substituted arylmethyl)‐4‐acylaminomethyloxazolidin‐2‐ones and Derivatization to Symmetrical Twin‐Drug Type Molecules.
Authors: Fujisaki Fumiko , Hiromatsu Sachi , Matsumura Yumiko , Fukami Aki , Kashige Nobuhiro , Miake Fumio , Sumoto Kunihiro 
Published: August 2013

AbstractMost of the synthesized compounds show antibacterial activity against S.
ChemInform Abstract: Pd‐Catalyzed C3‐Selective Arylation of Pyridines with Phenyl Tosylates.
Authors: Dai Fenglin , Gui Qingwen , Liu Jidan , Yang Zhiyong , Chen Xiang , Guo Ruqing , Tan Ze 
Published: August 2013

AbstractWhile the arylation of methylated pyridines with phenyl tosylates occurs in 3‐position (e.g. Vd), naphthyl tosylates react with 4‐methyl pyridine (IVd) at the methyl group [cf.
ChemInform Abstract: 1‐Benzyl‐3‐methylimidazolium Tetrafluoroborate as an Efficient and Green Reaction Medium for the Synthesis of Pyrimido[1,2‐a]benzimidazoles
Authors: Li Yu‐Ling , Cai Gan , Liu Xiao‐Jun , Wang Kai , Du Bai‐Xiang 
Published: August 2013

Abstractvia a multicomponent reaction
ChemInform Abstract: Stereoselective Synthesis of Substituted 1,4‐Oxazepanes by Intramolecular Reductive Etherification.
Authors: Gharpure Santosh J. , Prasad J. V. K. 
Published: August 2013

AbstractThe new reductive etherification is found to be fairly general, giving access to 2‐substituted, 7‐substituted, 2,5‐disubstituted, 2,6‐disubstituted, 2,7‐disubstituted, and bicyclic oxazepanes in good yields with good diastereoselectivities.