bluuebunny/crossref_metadata_2025_split huggingface dataset:
Melatonin supplementation counteracts fiber loss in knee ligaments of diabetes-induced rats
Authors: Adamska Olga , Wnuk Artur , Kamińska Agnieszka , Poniatowska Małgorzata , Maciąg Bartosz , Kamiński Maciej , Stolarczyk Artur , Matin Maima , Atanasov Atanas G. , Łapiński Marcin , Jóźwik Artur 
Published: July 2024

Diabetes mellitus (DM) is a prevalent metabolic disease. The clinical impact of sustained hyperglycemia on ligament healing has not been well characterized. Diabetes is a known cause of macro-, microvascular, and diabetic ulcer healing difficulties among tissues. Therefore, we aimed to investigate the healing potential occurring in injured and healthy ligaments among diabetic and healthy individuals using a rat model. We hypothesize that DM may contribute to altering the knee medial collateral ligament (MCL), thus its morphology, biochemical fitness, and functionality. The study cohort consisted of 40 rats. The animals were randomized into four equal groups. Groups I and II (20 rats) received saline subcutaneously and served as controls. Groups III and IV (20 rats) were injected with a single dose of streptozotocin (STZ). All animals underwent surgery to cut the left tibial collateral ligament in the hind limb and suture it. The access site was sutured to create inflammation and study the regenerative capacities of animals with normal carbohydrate metabolism and pharmacologically induced diabetes. Each animal then underwent sham surgery to access and suture the right tibial collateral ligament in the hind limb without ligament intervention. After the animals had undergone surgeries, groups II and IV were given melatonin supplementation for 4 weeks. Rats with DM presented with more fibrosis and calcification of the MCL and decreased healing potential. Treatment with melatonin in diabetic rats mitigated alterations and improved the antioxidant status of ligaments from the diabetic group.
Recombinant human luteinizing hormone increases endometrial thickness in women undergoing assisted fertility treatments: a systematic review and meta-analysis
Authors: Mao Routong , Hou Xiaohong , Feng Xiao , Wang Ruina , Fei Xiaofan , Zhao Junzhao , Chen Hui , Cheng Jing 
Published: July 2024

IntroductionThe optimal dosage of recombinant human luteinizing hormone (r-hLH) and its impact on endometrial thickness (EMT) when administered alongside recombinant human follicle-stimulating hormone (r-hFSH) during controlled ovarian stimulation (COS) for in vitro fertilization/intracytoplasmic sperm injection and embryo transfer are uncertain, which formed the aims of this systematic review and meta-analysis.MethodA search was performed in PubMed, Cochrane Library, Web of Science, EMBASE, CNKI, and Wanfang from its inception to 10 July 2023. Twenty-seven Randomized controlled trials comparing r-hFSH/r-hLH co-treatment with r-hFSH alone during in vitro fertilization/intracytoplasmic sperm injection and embryo transfer (IVF/ICSI-ET) were included. Pooled odds ratios (OR) for dichotomous data and mean differences (MD) for continuous data, with their respective 95% confidence intervals (CI), were generated. Meta-analysis employed fixed-effect or random-effect models based on heterogeneity, using Q-test and I2-index calculations. The main outcomes included EMT on trigger day, clinical pregnancy rate (CPR) and live birth rate (LBR).Resultsr-hFSH/r-hLH significantly increased EMT on trigger day (MD = 0.27; 95% CI, 0.11–0.42; I2 = 13%), but reduced oocyte number (MD = −0.60; 95% CI, −1.07 to −0.14; I2 = 72%) and high-quality embryos (MD = −0.76; 95% CI, −1.41 to −0.10; I2 = 94%) than r-hFSH alone, more pronounced with the gonadotrophin-releasing hormone agonist long protocol. A subgroup analysis showed r-hLH at 75 IU/day increased CPR (OR = 1.23; 95% CI, 1.02–1.49; I2 = 16%) and EMT on trigger day (MD = 0.40; 95% CI, 0.19–0.61; I2 = 0%). Participants ≥35 years of age exhibited decreased retrieved oocytes (MD = −1.26; 95% CI, −1.78 to −0.74; I2 = 29%), but an increase in EMT on trigger day (MD = 0.26; 95% CI, 0.11–0.42; I2 = 29%).Conclusionr-hFSH/r-hLH during COS significantly improved EMT compared to r-hFSH alone. An r-hLH dose of 75 IU/day may be considered for optimal pregnancy outcomes, which still require further clinical studies to support this dosing regime.Systematic Review Registration[www.crd.york.ac.uk/PROSPERO], identifier [CRD42023454584].
Causal gene identification using mitochondria-associated genome-wide mendelian randomization in atrial fibrillation
Authors: Chen Ying , Li Bingxun , Xu Hongxuan , Wu Lin 
Published: July 2024

Background: Mitochondrial dysfunction is one of the important patho-mechanisms in the development of atrial fibrillation (AF) with underidentified genetic pathophysiology.Methods: Summarized data of methylation, expression and protein abundance levels of mitochondria-related genes were obtained from corresponding studies, respectively. Genes related to mitochondria dysfunction in associations with AF were obtained from the UK Biobank (discovery), and the FinnGen study (replication). Summary-data-based Mendelian randomization analysis (SMR) was performed to assess potential causal relationships between mitochondria-related genes related to the molecular features of AF. Colocalization analysis was further conducted to assess whether the identified signal pairs shared causal genetic variants.Results: Five mitochondria-related genes were found to have causal effects with AF in the sensitivity and the colocalization analyses. Strong associations with increased risk of AF were identified with increased expression level of 4 mitochondria-related genes, including PCCB (OR 1.09, 95% CI 1.05–1.12; PPH4 = 0.95), COX18 (OR 1.83, 95% CI 1.29–2.60; PPH4 = 0.83), SLC25A15 (OR 1.34, 95% CI 1.14-1.58; PPH4 = 0.85), and STX17 (OR 1.16, 95% CI 1.08–1.24; PPH4 = 0.76). Conversely, genetically predicted higher levels expression of UQCC1 (OR 0.94, 95% CI 0.91–0.97) were associated with decreased risk of AF. After further tissue-specific validation, genetically predicted expression levels of PCCB (OR 1.12, 95%, CI 1.01-1.24, p = 0.025) and STX17 (OR 1.13, 95%, CI 1.04-1.23, p = 0.006) in atrial appendage were strongly associated with the increased risk of AF.Conclusion: Mitochondria-related genes are involved either positively (PCCB, COX18, SLC25A15 and STX17) or negatively (UQCCI) in the pathogenesis and the development of AF. These candidate genes may serve as targets for potential development of agents in the prevention and treatment of AF.
Correlation between impostor syndrome among doctoral students and supervisor empathy in Tunisia
Authors: Slimi Oumayma , Muscella Antonella , Marsigliante Santo , Bahloul Mourad 
Published: July 2024

IntroductionThe prevalence of impostor syndrome among PhD students has increased rapidly in recent years, having very negative effects on their mental and psychological health as well as on their doctoral journey. This exploratory study aims to examine whether there is a causal correlation between impostor syndrome among PhD students and empathy among supervisors.MethodsThis study encompasses 562 doctoral students (300 females, 262 males) and 152 Tunisian supervisors (68 females, 84 males).ResultsEmploying ANOVA, significant influences on impostor syndrome emerge for gender, marital status, professional status, and the doctoral enrollment level (p &lt; 0.001). Concurrently, supervisors’ empathy is significantly affected by gender, marital status, and experience (p &lt; 0.001). Linear regression establishes a noteworthy negative correlation (p = 0.045): a 1-unit increase in empathy correlates with a 0.122-unit decrease in impostor syndrome.DiscussionThese findings underscore the intricate relationship between socio-professional factors, empathy, and impostor syndrome within the academic milieu, offering crucial insights for interventions and psychological support. The study aligns with the broader context of understanding mental health challenges in academia, emphasizing the imperative for ongoing support initiatives.
Assessing the Impact of a Tax Regime Change on the Efficiency of Investment Assets in an Oil and Gas Company
Authors: Лейберт Т.Б. , Халикова Э.А. , Даутова Я.Р. 
Published: July 2024

В условиях введения нового режима налогообложения для нефтегазовых компаний налога на дополнительный доход с добычи полезных ископаемых становится актуальной оценка экономической эффективности применения предлагаемый законодателем новой модели налогообложения, основанной на изъятии части дохода нефтегазовой компании. Авторы статьи представили сравнительный анализ традиционной и новой модели налогообложения объектов недропользования, а также на примере инвестиционного актива одного из крупнейших нефтегазовых российских компаний провели анализ влияния перехода компаний на налог на дополнительный доход на эффективность действующего месторождения.
Under the conditions of introducing a new tax regime for oil and gas companies a tax on additional income from mining, it becomes relevant to assess the economic efficiency of application of the new tax model proposed by the legislator, based on the withdrawal of a portion of the income of the oil and gas company, taking into account the return on the investment asset (oil field) and geological exploration features. The authors of the article presented a comparative analysis of the traditional and new model of taxation of subsoil objects on the basis of regulatory and legal regulation, as well as an example of the investment asset of one of the largest Russian oil and gas companies, which analyzed the effect of companies switching to a tax on additional income on the operating efficiency of an existing field.
Economic Mechanism of Industrial Safety Management
Authors: Радионова С.Г. , Котов Д.В. 
Published: July 2024

В статье рассматриваются вопросы экономического обоснования мероприятий по повышению уровня промышленной безопасности предприятий, эксплуатирующих опасные производственные объекты. Обосновано, что совершенствование управления промышленной безопасностью целесообразно осуществлять с использованием процессного подхода. При этом система бизнес-процессов предприятия выступает как механизм влияния на показатели уровня промышленной безопасности. Представлен механизм, который позволяет сопоставить потенциально реализуемые для повышения уровня промышленной безопасности мероприятия с бизнес-процессами и показателями уровня промышленной безопасности. Проиллюстрировано, как применение предложенного подхода повлияет на уровень промышленной безопасности трех предприятий трубопроводного транспорта.
The article discusses the issues of economic justification of measures to improve the industrial safety of enterprises operating hazardous production facilities. It has been substantiated that it is advisable to carry out improvements in the management of industrial safety using the process approach. At the same time, the system of business processes of an enterprise acts as a mechanism for influencing indicators of the level of industrial safety. A mechanism has presented а possibility to compare potentially implemented measures to increase the level of industrial safety with business processes and indicators of the level of industrial safety. It has been illustrated how the application of the proposed approach will affect the level of industrial safety of three pipeline transportation enterprises.
Competitiveness of the Workforce of the Organization from the Standpoint of Creating a Decent Level of Labor
Authors: Богатырева М.Р. 
Published: July 2024

В статье рассматривается конкурентоспособность рабочей силы как одного из важнейших аспектов человеческого капитала. Без сомнения, эффективность любой организации зависит от эффективности трудовых ресурсов. В статье описано несколько подходов к определению понятия конкурентоспособность трудовых ресурсов . Разнообразие подходов свидетельствует об отсутствии единого целостного определения понятия конкурентоспособность трудовых ресурсов , и о том, что определение конкурентоспособности работников зависит от создания достойного уровня труда. Авторы пришли к выводу, что для повышения конкурентоспособности человеческого капитала необходима коррекция государственной образовательной политики.
The article considers the competitiveness of the labor force as one of the most important aspects of human capital. Without a doubt, the effectiveness of any organization depends on the efficiency of the workforce. The article describes several approaches to the definition of the concept competitiveness of labor resources . The diversity of approaches indicates the absence of a single, holistic definition of the concept of competitiveness of labor resources , and that the definition of the competitiveness of workers depends on creating a decent level of labor. The authors concluded that in order to increase the competitiveness of human capital, it is necessary to reform the state educational policy.
Mechanism of Implementation of Strategic Management Decisions in the Organizations of the Sphere of Intangible Production
Authors: Гамбаров Т.Р. , Романцов А.Н. 
Published: July 2024

В статье рассмотрен иерархический механизм реализации стратегических решений, представлены характеристика стратегий, а также поэтапный процесс механизма управления принятием стратегических решений предложена блочная структура стратегических инициатив с точки зрения особенностей стратегических решений.
The article describes a hierarchical mechanism for the implementation of strategic decisions, presents a description of the strategies and the gradual process of the control mechanism of strategic decision-making the block structure of the strategic initiatives from the point of view of the characteristics of strategic decisions is proposed.
KEANEKARAGAMAN AMFIBI DAN REPTIL DI KAWASAN WISATA SITU BAGENDIT DAN SEKITARNYA, KABUPATEN GARUT PROVINSI JAWA BARAT
Authors: Kurnia Insan , Nurfadhilah Nyimas Aisyah , Syahrahmani Aluna , Liani Hikmah Rachma , Lawana Dewa Dzullfadhil , Nathaniel Bernado Raphael 
Published: July 2024

Amphibians and reptiles are two groups of wildlife that are ecologically close and related to aquatic ecosystems. Â Setu Bagendit is a freshwater ecosystem with a variety of other habitats around it. Â The research aims to analyze diversity of amphibians and reptiles in Setu Bagendit Tourism Area and its surroundings. The research was carried out in June 2023 using a combination of a 100 meter transect method and time search of 30 minutes. Â Data analysis was carried out qualitatively and quantitatively by diversity index (H'), evenness index (E) and similarity index (SI). There were a total of 18 species of amphibians and reptiles from two orders and 11 families. All species are cosmopolitan, that widely distributed with high adaptability to live in disturbed habitats and close to human living environments. The values of H' obtained ranged from 0.56-2.37, while E values obtained ranged from 0.78-0.87. Â The SI ranges from 0.00-0.64.
ANALISIS KARAKTERISTIK KAPASITAS MASYARAKAT DALAM PENGELOLAAN HUTAN LINDUNG GUNUNG GEULIS KABUPATEN SUMEDANG JAWA BARAT-INDONESIA
Authors: Pujo Pujo 
Published: July 2024

Community-based forest management or social forestry approach has been implemented to increase community involvement in forestry development. Community capacity to collaborate is needed to realize sustainable community-based forest management. The object of research is to determine the community capacity characteristics and the factors that influence community capacity in developing forest management cooperation. The method of research by survey methods with purposive sampling was 60 respondents. The community capacity characteristics were analyzed using the factor analysis method. The research results found that the community capacity characteristics can be grouped into 2 (two), namely: individual level and group or community level. The individual level is described by 16 variables. The new knowledge about the level of grouping which describes the existence of levels or ladders of community capacity characteristics starting from the lowest variable is sense of community to the highest variable, namely social capital. The results of statistical tests on the community capacity characteristics show that the level of community capacity in collaborating is low category. The results of this research confirm one of the community capacity characteristic variables that has a strong influence namely social capital. Therefore, cooperative behavior in managing MGPF needs to be increased by developing community capacity through strengthening social capital.

Keywords: community capacity, cooperation, community-based forest management.
Profil Gangguan Pendengaran Berdasarkan Pemeriksaan Audiometri di Instalasi Rawat Jalan Telinga Hidung Tenggorok dan Bedah Kepala Leher RSUP Prof. Dr. R. D. Kandou
Authors: Firdaus Septiana , Pontoh Valentini M. , Pelealu Olivia C. P. 
Published: July 2024

Abstract: Hearing loss is a person's inability to hear sound in one or both ears in either part of the auditory system or the whole. Hearing loss can occur in all age groups due to organ structure damage or certain medical conditions. This study aimed to obtain the profile of outpatiens’ hearing loss based on audiometry examination at Installation of Ear Nose Throat and Head Neck Surgery Prof. Dr. R. D. Kandou Hospital. This was a retrospective and descriptive study with a cross sectional design. The results showed that there were 207 patients with hearing loss based on audiometry examination. The highest number of cases was in 2022 (59%). Hearing loss was more frequently experienced by males (55%), and occured at the age of 20-60 years (57%). Symptoms that arised in hearing loss patients include decreased hearing, ear pain, difficulty in communicating, and tinnitus. The most common type of hearing loss was conductive hearing loss (CHL) (43.6%). In conclusion, hearing loss is often experienced by male patients, and occurs at the age of 20-60 years. The most common causes of hearing loss are untreated wax buildup in the ear canal and exposure to high-intensity noise. Using audiometric examination can determine advanced management according to the type of hearing loss.
Keywords: hearing process; hearing loss; audiometry

Abstrak: Gangguan pendengaran merupakan ketidakmampuan seseorang untuk mendengarkan suara pada salah satu atau kedua telinga baik pada sebagian sistem pendengaran atau keseluruhan. Gangguan pendengaran dapat terjadi pada semua kelompok usia, akibat kerusakan struktur organ atau kondisi medis tertentu. Penelitian ini bertujuan untuk mendapatkan profil gangguan pendengaran berdasarkan pemeriksaan audiometri di Instalasi Rawat Jalan Telinga Hidung Tenggorok dan Bedah Kepala Leher RSUP Prof. Dr. R. D. Kandou tahun 2020-2022. Jenis penelitian ialah deskriptif retrospektif dengan desain potong lintang. Hasil penelitian mendapatkan sampel 207 penderita gangguan pendengaran yang dilakukan pemeriksaan audiometri. Penderita terbanyak pada tahun 2022 (59%). Gangguan pendengaran lebih sering dialami oleh laki-laki dengan total 114 kasus (55%), dan terjadi pada usia 20-60 tahun sebanyak 117 kasus (57%). Gejala yang sering timbul pada penderita gangguan pendengaran antara lain penurunan pendengaran, nyeri telinga, sulit berkomunikasi, dan telinga berdenging. Jenis gangguan pendengaran tersering yaitu conductive hearing loss (CHL) (43,6%). Simpulan penelitian ini ialah gangguan pendengaran sering dialami oleh laki-laki dan terjadi pada usia 20-60 tahun. Penyebab tersering gangguan pendengaran yaitu penumpukan serumen pada saluran telinga dan paparan dari kebisingan intensitas tinggi. Dengan pemeriksaan audiometri maka dapat ditentukan manajemen lanjutan sesuai jenis gangguan pendengaran.
Kata kunci: proses mendengar; gangguan pendengaran; audiometri
Innovative development of the library: project solutions and grant programs
Authors: Mudrokha Valentyna 
Published: July 2024

The purpose of the article. The article presents the experience of participation V. Stefanyk LNSL of Ukraine in the "Great Restoration" program of the national project "Great Construction" (2021), as well as grant programs from the Ukrainian Cultural Foundation "Cultural Heritage" (2023; 2024). The research methodology involves the use of a set of research methods: analysis, synthesis, classification and systematization of theoretical data, analytical and documentary analysis. The scientific novelty of the work is that: 1) the main ideas of the developed projects, features and specifics of their implementation are considered; 2) expected results are outlined; 3) it has been established that digitization of books, on the one hand, contributes to the preservation and protection of unique, rare and valuable editions, and on the other hand, it provides an opportunity to create an insurance fund for the library; 4) representation on the official website of the institution of digital collections and provision of open access to them 24/7 contributes to the disclosure of the funds of the V. Stefanyk LNSL of Ukraine, to publicize its rich historical and cultural heritage and national heritage for a wide audience of interested persons. Conclusions. Attracting additional funds will enable the institution not only to improve its material and technical base, but also to implement many more creative and creative projects, which would be impossible due to lack of funding and lack of necessary equipment. The library's participation in open projects and grant competitions has a positive effect on the professional development of employees, as it ensures that they acquire new skills and knowledge related to the specifics of development and effective implementation into life of innovative ideas.
The role of metadata in the organization of access to the digital collections of the electronic library
Authors: Melnyk-Khokha Galyna 
Published: July 2024

Metadata has been proven to play a key role in managing bibliographic data in digital form. The use of metadata contributes to the efficiency of organization of access, search and management of bibliographic data. Through a systematic analysis of the use of metadata in the formation of digital collections, in particular on the example of the description of digital copies of archival documents from the Library's collection of the Manuscripts Department of the NTSh in Lviv, it was established that metadata significantly facilitates access, search, integration and management of digital resources. The analysis of the specifics of the use of metadata in the formation of the Library's digital collections confirms their significance. The scientific novelty of the work consists in the systematic study of the specifics of the application of metadata in this context. The proposed research methodology, which includes the analysis of standards, the development of a metadata scheme, annotation, testing and implementation of metadata, contributes to the improvement of accessibility, organization and structuring of digital collections in the library electronic infrastructure. The article analyzes the role of metadata in solving the problems of digital bibliographic data, such as access, search, integration and data management. A research methodology is proposed, which includes studying existing metadata standards and recommendations, developing a metadata schema, creating annotations for archival documents, performance testing, selecting metadata types, and implementation. This approach made it possible to systematize the process of forming digital collections and improve the accessibility, organization and finding of digital resources in the library's electronic infrastructure.