bluuebunny/crossref_metadata_2025_split huggingface dataset:
From efficiency to resilience: unraveling the dynamic coupling of land use economic efficiency and urban ecological resilience in Yellow River Basin
Authors: Yu Tonghui , Jia Shanshan , Cui Xufeng 
Published: July 2024

AbstractThis study investigates the Dynamic Coupling between Land Use Economic Efficiency (LUEE) and Urban Ecological Resilience (UER) in the Yellow River Basin (YRB). This exploration is pivotal for elucidating the interaction mechanisms between economic growth and ecological governance. Furthermore, understanding this relationship is essential for fostering high-quality, sustainable urban development in the YRB. Utilizing panel data from 56 cities spanning 2003 to 2020, this study employed the coupling coordination degree (CCD) model, spatial correlation analysis, Kernel density estimation, convergence model, and Geodetector to systematically analyze the spatio-temporal distribution, dynamic trend, and determinants of the CCD between LUEE and UER in the YRB. The findings indicate that: (1) A general upward trend in both LUEE and UER, accompanied by a steady improvement in their CCD. (2) Significant spatial disparities in their CCD, with higher levels in the lower reaches. (3) Marked positive spatial autocorrelation, predominantly characterized by clusters where high (low) values are surrounded by high (low) values. (4) Regarding the impact of individual factors, government fiscal budget expenditure demonstrates the most robust explanatory power for the CCD within the YRB. Concerning the effects of two-factor interactions, the interplay between industrial structure upgrading and government fiscal budget expenditure emerges as the most significant determinant in influencing the CCD between LUEE and UER. This study enhances our comprehensive understanding of the interplay between economic and ecological systems. It offers scientific insights and strategic direction for harmonizing ecological governance with urban economic growth at both the regional and global scales.
Study on the temporal and spatial distribution of Culex mosquitoes in Hanoi, Vietnam
Authors: Krambrich Janina , Nguyen-Tien Thang , Pham-Thanh Long , Dang-Xuan Sinh , Andersson Ella , Höller Patrick , Vu Duoc Trong , Tran Son Hai , Vu Lieu Thi , Akaberi Dario , Ling Jiaxin , Pettersson John H.-O. , Hesson Jenny C. , Lindahl Johanna F. , Lundkvist Åke 
Published: July 2024

AbstractArboviruses transmitted by mosquitoes, including Japanese encephalitis virus (JEV), present a substantial global health threat. JEV is transmitted by mosquitoes in the genus Culex, which are common in both urban and rural areas in Vietnam. In 2020, we conducted a 1-year survey of Culex mosquito abundance in urban, suburban, and peri-urban areas of Hanoi using CDC-light traps. Mosquitoes were identified to species and sorted into pools based on species, sex, and trap location. The mosquito pools were also investigated by RT-qPCR for detection of JEV. In total, 4829 mosquitoes were collected over a total of 455 trap-nights, across 13 months. Collected mosquitoes included Culex, Aedes, Anopheles, and Mansonia species. Culex mosquitoes, primarily Cx. quinquefasciatus, predominated, especially in peri-urban areas. Most Culex mosquitoes were caught in the early months of the year. The distribution and abundance of mosquitoes exhibited variations across urban, suburban, and peri-urban sites, emphasizing the influence of environmental factors such as degree of urbanization, temperature and humidity on Culex abundance. No JEV was detected in the mosquito pools. This study establishes baseline knowledge of Culex abundance and temporal variation, which is crucial for understanding the potential for JEV transmission in Hanoi.
Effect of seawater salinity, pH, and temperature on external corrosion behavior and microhardness of offshore oil and gas pipeline: RSM modelling and optimization
Authors: Chohan Imran Mir , Ahmad Azlan , Sallih Nabihah , Bheel Naraindas , Salilew Waleligne Molla , Almaliki Abdulrazak H. 
Published: July 2024

AbstractThis research aims to investigate the effects of seawater parameters like salinity, pH, and temperature on the external corrosion behaviour and microhardness of offshore oil and gas carbon steel pipes. The immersion tests were performed for 28 days following ASTM G-1 standards, simulating controlled artificial marine environments with varying pH levels, salinities, and temperatures. Besides, Field emission scanning electron microscopy (FESEM) analysis is performed to study the corrosion morphology. Additionally, a Vickers microhardness tester was used for microhardness analysis. The results revealed that an increase in salinity from 33.18 to 61.10 ppt can reduce the corrosion rate by 28%. In contrast, variations in seawater pH have a significant effect on corrosion rate, with a pH decrease from 8.50 to 7 causing a 42.54% increase in corrosion rate. However, the temperature of seawater was found to be the most prominent parameter, resulting in a 76.13% increase in corrosion rate and a 10.99% reduction in the microhardness of offshore pipelines. Moreover, the response surface methodology (RSM) modelling is used to determine the optimal seawater parameters for carbon steel pipes. Furthermore, the desirability factor for these parameters was 0.999, and the experimental validation displays a good agreement with predicted model values, with around 4.65% error for corrosion rate and 1.36% error for microhardness.
Exploring dose–response variability and relative severity assessment in STZ-induced diabetes male NSG mice
Authors: Talbot Steven R. , Heider Miriam , Wirth Martin , Jörns Anne , Naujok Ortwin 
Published: July 2024

AbstractNSG mice are among the most immunodeficient mouse model being used in various scientific branches. In diabetelogical research diabetic NSG mice are an important asset as a xenotransplantation model for human pancreatic islets or pluripotent stem cell-derived islets. The treatment with the beta cell toxin streptozotocin is the standard procedure for triggering a chemically induced diabetes. Surprisingly, little data has been published about the reproducibility, stress and animal suffering in these NSG mice during diabetes induction. The 3R rules, however, are a constant reminder that existing methods can be further refined to minimize suffering. In this pilot study the dose–response relationship of STZ in male NSG mice was investigated and additionally animal suffering was charted by applying the novel ‘Relative Severity Assessment’ algorithm. By this we successfully explored an STZ dose that reliably induced diabetes while reduced stress and pain to the animals to a minimum using evidence-based and objective parameters rather than criteria that might be influenced by human bias.
Insights into the genomic homogeneity of Moroccan indigenous sheep breeds though the lens of runs of homozygosity
Authors: Kusza Szilvia , Badaoui Bouabid , Wanjala George 
Published: July 2024

AbstractNumerous studies have indicated that Morocco’s indigenous sheep breeds are genetically homogenous, posing a risk to their survival in the challenging harsh climate conditions where they predominantly inhabit. To understand the genetic behind genetic homogeneity through the lens of runs of homozygosity (ROH), we analyzed the whole genome sequences of five indigenous sheep breeds (Beni Guil, Ouled Djellal, D’man, Sardi, Timahdite and Admixed).The results from principal component, admixture, Fst, and neighbour joining tree analyses consistently showed a homogenous genetic structure. This structure was characterized by an average length of 1.83 Mb for runs of homozygosity (ROH) segments, with a limited number of long ROH segments (24–48 Mb and > 48 Mb). The most common ROH segments were those ranging from 1–6 Mb. The most significant regions of homozygosity (ROH Islands) were mostly observed in two chromosomes, namely Chr1 and Chr5. Specifically, ROH Islands were exclusively discovered in the Ouled Djellal breed on Chr1, whereas Chr5 exhibited ROH Islands in all breeds. The analysis of ROH Island and iHS technique was employed to detect signatures of selection on Chr1 and Chr5. The results indicate that Chr5 had a high level of homogeneity, with the same genes being discovered across all breeds. In contrast, Chr1 displays some genetic variances between breeds. Genes identified on Chr5 included SLC39A1, IL23A, CAST, IL5, IL13, and IL4 which are responsible for immune response while genes identified on Chr1 include SOD1, SLAMF9, RTP4, CLDN1, and PRKAA2. ROH segment profile and effective population sizes patterns suggests that the genetic uniformity of studied breeds is the outcome of events that transpired between 250 and 300 generations ago. This research not only contributes to the understanding of ROH distribution across breeds but helps design and implement native sheep breeding and conservation strategies in Morocco. Future research, incorporating a broader sample size and utilizing the pangenome for reference, is recommended to further elucidate these breeds’ genomic landscapes and adaptive mechanisms.
Preparation and characterization of innovative cement mortar incorporating fatty acid/expanded graphite composite phase change material for thermal energy storage
Authors: Zhou Dongyi , Xiao Shuaizhe , Liu Yicai 
Published: July 2024

AbstractTo explore the application of phase change energy storage materials in building energy conservation, in this study, an innovative composite thermal energy storage cement mortar (CTESCM) was developed using lauric acid–palmitic acid/expanded graphite (LA-PA/EG) as the composite phase change material (CPCM). Seven different CTESCM test blocks with different CPCM mass contents were prepared. The thermal characterization of the CTESCMs was achieved using a differential scanning calorimeter (DSC), a thermogravimetric analysis (TGA), thermal conductivity tests, and heat storage/release tests. The physical behavior was assessed using density, mechanical performance was assessed using compressive strength, and the microstructure was observed using a scanning electron microscope (SEM). The results indicate that the phase transition temperature of the CTESCMs was lower than that of the LA-PA/EG CPCM, and the latent heat consistently decreased with the decrease of the CPCM mass content. With the addition of the CPCM, which had a low-density porous structure, the thermal conductivity, density, and compressive strength of the CTESCMs decreased. CTESCM with a mass fraction of 20%C (20% cement) CPCM can be used for building energy conservation such as floor radiation heating systems.
Antibodies targeting the glycan cap of Ebola virus glycoprotein are potent inducers of the complement system
Authors: Ilinykh Philipp A. , Huang Kai , Gunn Bronwyn M. , Kuzmina Natalia A. , Kedarinath Kritika , Jurado-Cobena Eduardo , Zhou Fuchun , Subramani Chandru , Hyde Matthew A. , Velazquez Jalene V. , Williamson Lauren E. , Gilchuk Pavlo , Carnahan Robert H. , Alter Galit , Crowe James E. , Bukreyev Alexander 
Published: July 2024

AbstractAntibodies to Ebola virus glycoprotein (EBOV GP) represent an important correlate of the vaccine efficiency and infection survival. Both neutralization and some of the Fc-mediated effects are known to contribute the protection conferred by antibodies of various epitope specificities. At the same time, the role of the complement system remains unclear. Here, we compare complement activation by two groups of representative monoclonal antibodies (mAbs) interacting with the glycan cap (GC) or the membrane-proximal external region (MPER) of GP. Binding of GC-specific mAbs to GP induces complement-dependent cytotoxicity (CDC) in the GP-expressing cell line via C3 deposition on GP in contrast to MPER-specific mAbs. In the mouse model of EBOV infection, depletion of the complement system leads to an impairment of protection exerted by one of the GC-specific, but not MPER-specific mAbs. Our data suggest that activation of the complement system represents an important mechanism of antiviral protection by GC antibodies.
Selenoprotein W modulates tau homeostasis in an Alzheimer’s disease mouse model
Authors: Ren Bingyu , Situ Jiaxin , Huang Xuelian , Tan Qiulong , Xiao Shifeng , Li Nan , Tian Jing , Du Xiubo , Ni Jiazuan , Liu Qiong 
Published: July 2024

AbstractLower selenium levels are observed in Alzheimer’s disease (AD) brains, while supplementation shows multiple benefits. Selenoprotein W (SELENOW) is sensitive to selenium changes and binds to tau, reducing tau accumulation. However, whether restoration of SELENOW has any protective effect in AD models and its underlying mechanism remain unknown. Here, we confirm the association between SELENOW downregulation and tau pathology, revealing SELENOW’s role in promoting tau degradation through the ubiquitin‒proteasome system. SELENOW competes with Hsp70 to interact with tau, promoting its ubiquitination and inhibiting tau acetylation at K281. SELENOW deficiency leads to synaptic defects, tau dysregulation and impaired long-term potentiation, resulting in memory deficits in mice. Conversely, SELENOW overexpression in the triple transgenic AD mice ameliorates memory impairment and tau-related pathologies, featuring decreased 4-repeat tau isoform, phosphorylation at Ser396 and Ser404, neurofibrillary tangles and neuroinflammation. Thus, SELENOW contributes to the regulation of tau homeostasis and synaptic maintenance, implicating its potential role in AD.
Quantized polarization and Majorana fermions beyond tenfold classification
Authors: Han Sang-Hoon , Kang Myungjun , Park Moon Jip , Cheon Sangmo 
Published: July 2024

AbstractExploration of topology is central in condensed matter physics and applications to fault-tolerant quantum information. The bulk-boundary correspondence and tenfold classification determine the topological state compared to a vacuum. Contrary to this belief, we demonstrate that topological zero-energy domain-wall states can emerge for all forbidden 1D classes of the tenfold classification table. The guiding principle is that the difference in the topological quantities of two trivial domains can be quantized, and hence, a topologically protected state can emerge at the domain wall. Such nontrivial domain-wall states are demonstrated using generalized Su-Schrieffeer-Heeger and generalized Kitaev models, which manifest quantized polarization and Majorana fermions, respectively. The quantized Berry phase difference between the domains protects the non-trivial nature of the domain-wall states, extending the bulk-boundary correspondence, also confirmed by the tight-binding and Jackiw-Rebbi methods. Furthermore, we show that the seemingly trivial electronic and superconducting models can be transformed into their topological counterparts in the framework of the topological Fermi-liquid theory. Finally, we propose potential systems where our results may be realized, spanning from electronic and superconducting to optical systems.
Mass spectrometry imaging for spatially resolved multi-omics molecular mapping
Authors: Zhang Hua , Lu Kelly H. , Ebbini Malik , Huang Penghsuan , Lu Haiyan , Li Lingjun 
Published: July 2024

AbstractThe recent upswing in the integration of spatial multi-omics for conducting multidimensional information measurements is opening a new chapter in biological research. Mapping the landscape of various biomolecules including metabolites, proteins, nucleic acids, etc., and even deciphering their functional interactions and pathways is believed to provide a more holistic and nuanced exploration of the molecular intricacies within living systems. Mass spectrometry imaging (MSI) stands as a forefront technique for spatially mapping the metabolome, lipidome, and proteome within diverse tissue and cell samples. In this review, we offer a systematic survey delineating different MSI techniques for spatially resolved multi-omics analysis, elucidating their principles, capabilities, and limitations. Particularly, we focus on the advancements in methodologies aimed at augmenting the molecular sensitivity and specificity of MSI; and depict the burgeoning integration of MSI-based spatial metabolomics, lipidomics, and proteomics, encompassing the synergy with other imaging modalities. Furthermore, we offer speculative insights into the potential trajectory of MSI technology in the future.
Palm vein imaging using a polarization-selective metalens with wide field-of-view and extended depth-of-field
Authors: Kuang Ying , Wang Shuai , Mo Bincheng , Sun Shiyou , Xia Kai , Yang Yuanmu 
Published: July 2024

AbstractMetalens is a flat, lightweight optical element that may replace traditional bulky refractive lenses and other components in imaging systems. However, a number of critical challenges still remain for most metalenses demonstrated to date, including limited field-of-view (FOV), depth-of-field (DOF), and working bandwidth, which restrict their use in a real-world application. Here, we propose and experimentally demonstrate a compact imaging system equipped with a metalens that simultaneously features a wide FOV of 140° and an extended DOF ranging from 33 to 150 mm. The metalens further allows polarization selectivity, which can be used to remove unwanted surface reflection of the target scene. Using a narrowband vertical-cavity surface-emitting laser for illumination, we show that the system is well-suited for near-infrared palm vein imaging, an emerging modality for biometric identification. The metalens-integrated imaging system provides uncompromised performance with a greatly simplified form factor compared to a traditional system, which may also be adopted for other applications such as depth sensing and endoscopy.
Advanced optical polarizers based on 2D materials
Authors: Zhang Yuning , Wu Jiayang , Jia Linnan , Jin Di , Jia Baohua , Hu Xiaoyong , Moss David , Gong Qihuang 
Published: July 2024

AbstractOptical polarizers are essential components for the selection and manipulation of light polarization states in optical systems. Over the past decade, the rapid advancement of photonic technologies and devices has led to the development of a range of novel optical polarizers, opening avenues for many breakthroughs and expanding applications across diverse fields. Particularly, two-dimensional (2D) materials, known for their atomic thin film structures and unique optical properties, have become attractive for implementing optical polarizers with high performance and new features that were not achievable before. This paper reviews recent progress in 2D-material-based optical polarizers. First, an overview of key properties of various 2D materials for realizing optical polarizers is provided. Next, the state-of-the-art optical polarizers based on 2D materials, which are categorized into spatial-light devices, fiber devices, and integrated waveguide devices, are reviewed and compared. Finally, we discuss the current challenges of this field as well as the exciting opportunities for future technological advances.
Distinct functional and molecular profiles between physiological and pathological atrial enlargement offer potential new therapeutic opportunities for atrial fibrillation
Authors: Chen Yi Ching , Wijekoon Seka , Matsumoto Aya , Luo Jieting , Kiriazis Helen , Masterman Emma , Yildiz Gunes , Cross Jonathon , Parslow Adam C. , Chooi Roger , Sadoshima Junichi , Greening David W. , Weeks Kate L. , McMullen Julie R. 
Published: July 2024

Abstract
Atrial fibrillation (AF) remains challenging to prevent and treat. A key feature of AF is atrial enlargement. However, not all atrial enlargement progresses to AF. Atrial enlargement in response to physiological stimuli such as exercise is typically benign and reversible. Understanding the differences in atrial function and molecular profile underpinning pathological and physiological atrial remodelling will be critical for identifying new strategies for AF. The discovery of molecular mechanisms responsible for pathological and physiological ventricular hypertrophy has uncovered new drug targets for heart failure. Studies in the atria have been limited in comparison. Here, we characterised mouse atria from (1) a pathological model (cardiomyocyte-specific transgenic (Tg) that develops dilated cardiomyopathy [DCM] and AF due to reduced protective signalling [PI3K]; DCM-dnPI3K), and (2) a physiological model (cardiomyocyte-specific Tg with an enlarged heart due to increased insulin-like growth factor 1 receptor; IGF1R). Both models presented with an increase in atrial mass, but displayed distinct functional, cellular, histological and molecular phenotypes. Atrial enlargement in the DCM-dnPI3K Tg, but not IGF1R Tg, was associated with atrial dysfunction, fibrosis and a heart failure gene expression pattern. Atrial proteomics identified protein networks related to cardiac contractility, sarcomere assembly, metabolism, mitochondria, and extracellular matrix which were differentially regulated in the models; many co-identified in atrial proteomics data sets from human AF. In summary, physiological and pathological atrial enlargement are associated with distinct features, and the proteomic dataset provides a resource to study potential new regulators of atrial biology and function, drug targets and biomarkers for AF.
Internal and external disturbances aware motion planning and control for quadrotors
Authors: Zhou Xiaobin , Wang Miao , Cui Can , Wang Yongchao , Xu Chao , Gao Fei 
Published: July 2024

AbstractResilient motion planning and control, without prior knowledge of disturbances, are crucial to ensure the safe and robust flight of quadrotors. The development of a motion planning and control architecture for quadrotors, considering both internal and external disturbances (i.e., motor damages and suspended payloads), is addressed. Firstly, the authors introduce the use of exponential functions to formulate trajectory planning. This choice is driven by its ability to predict thrust responses with minimal computational overhead. Additionally, a reachability analysis is incorporated for error dynamics resulting from multiple disturbances. This analysis sits at the interface between the planner and controller, contributing to the generation of more robust and safe spatial–temporal trajectories. Lastly, the authors employ a cascade controller, with the assistance of internal and external loop observers, to further enhance resilience and compensate the disturbances. The authors’ benchmark experiments demonstrate the effectiveness of the proposed strategy in enhancing flight safety, particularly when confronted with motor damages and payload disturbances.
Unreliability tracing of power systems with reservoir hydropower based on a temporal recursive model
Authors: Bai Yunjie , Xie Kaigui , Shao Changzheng , Hu Bo 
Published: July 2024

AbstractPower system unreliability tracing model allocates the system's reliability index to individual components, identifying potential weaknesses. This study expands its scope by considering the impact of storage resources. Unreliable factors leading to load shedding are categorized into two groups: objective factors inherent to the component and insufficient storage resources. The latter requires a retrospective analysis of other components that caused unreliability previously. When allocating responsibility for load shedding at a certain time, it begins by allocating it among components based on differences between fixed expected output and actual supply. Expected output insufficiency is considered as the unreliable factor. This insufficiency due to insufficient storage resources is then decomposed into segments, each caused by excessive output in earlier instances of the same component. The expected output excess is attributed to the expected output insufficiency of other components in previous times, for which responsibility has been allocated to each component. Consequently, the expected output insufficiency at a particular time can be traced back based on a temporal recursive model, with the load shedding further allocated to components before that time. Case studies based on several systems demonstrate that the proposed model's allocation results are reasonable and more accurate than the traditional model.