bluuebunny/crossref_metadata_2025_split huggingface dataset:
HEAD: High-Speed Approximate HEterogeneous ADder for Error-Resilient Applications
Authors: Guturu Sahith , Anil Kumar Uppugunduru , Verma Shruti , Ahmed Syed Ershad 
Published: July 2024

Media processing applications can tolerate error up to a certain limit due to the perceptual limitations of the human eye. Since adders are ubiquitous in power-hungry media processing applications, they can be approximated without much compromise in quality. An adder with better error characteristics without significant compromise in area and power is required to meet the future demands of ever-increasing computational needs. In order to achieve the same, a novel segmentation technique has been proposed. By varying the number of bits in each segment, three different designs are proposed, each with its advantage. Each proposed adder is segmented into three portions, namely Most Significant Portion (MSP), Intermediate Significant Portion (ISP) and Least Significant Portion (LSP). The sub-adder’s sum in each portion is computed concurrently to reduce the critical path delay. The proposed heterogeneous adder (HEAD) designs achieve better accuracy than the state-of-the-art designs. Synthesis results show that HEAD consumes less area up to 41.8% and consumes less power ranging from 0.8% to 51%, than existing adders. Exhaustive simulations are carried out on benchmarking image sharpening application to prove that the proposed adders obtain a better quality-effort tradeoff than the existing designs.
INFLUENCE OF CuO NANOPARTICLES ON THE STRUCTURAL PROPERTIES, SURFACE CHARACTERISTICS, AND OPTICAL BEHAVIOR OF POLY(4-CHLOROANILINE) POLYMERIC FILMS
Authors: ALOTAIBI B. M. , AL-YOUSEF HAIFA A. , ATTA A. , ABDELTWAB E. 
Published: July 2024

In this study, the composite P(4ClAni)/CuO, which consists of Poly(4-Chloroaniline) P(4ClAni) and copper oxide (CuO) nanoparticles, was successfully synthesized utilizing a chemically oxidative polymerization approach to be applied in optoelectronics. Both FTIR and EDX analyses showed that CuO has been successfully integrated into the P(4ClAni) matrix. The SEM micrographs reveal uniform loading and distribution of CuO throughout the P(4ClAni) polymeric chains. The UV–Vis absorbance, the Urbach energy, the band edge and a number of carbon clusters were determined. The Tauc relationship was used to determine the band gaps, which revealed a decrease as the CuO concentration increased. The band gap drops from 3.84[Formula: see text]eV for P(4ClAni) to 3.09, 2.85, and 2.64[Formula: see text]eV, correspondingly for P(4ClAni)/CuO-1, P(4ClAni)/CuO-2, and P(4ClAni)/CuO-3. While, the Urbach tail is increased from 1.66[Formula: see text]eV for P(4ClAni) correspondingly to 1.81, 1.85, and 1.93[Formula: see text]eV. The results show composites made of P(4ClAni)/CuO have better optical characteristics than pure polymer P(4ClAni), suggesting that they can use these composites in optoelectronics devices.
Healthcare Professionals’ Attitude to Using Mobile Health Technology and Its Associated Factors in a Resource‐Limited Country—An Implication for Digital Health Implementers: A Cross Sectional Study
Authors: Walle Agmasie Damtew , Butta Fikadu Wake , Kassie Sisay Yitayih , Chereka Alex Ayenew , Kanfe Shuma Gosha , Dubale Abiy Tasew , Enyew Ermias Bekele , Dube Geleta Nenko , Shibabaw Adamu Ambachew , Hunde Mekonnen Kenate , Kitil Gemeda Wakgari , Ferede Tigist Andargie , Wubante Sisay Maru , Baykemagn Nebebe Demis , Demsash Addisalem Workie 
Published: July 2024

Background: Mobile health has become widely used within the healthcare system, and there is an increasing worldwide trend toward employing this innovation for behavior management, disease monitoring, the control and prevention of various health issues, and rising enrollment in healthcare services. Although mHealth is becoming more widely available, there is no evidence about the attitude of healthcare professionals toward mHealth in southwest Ethiopia. Therefore, this study is aimed at assessing the attitude of healthcare professionals to using mHealth technology and associated factors in Ethiopia.Methods: An institutional cross‐sectional study was conducted among 422 healthcare professionals. Data were collected using a pretested interviewer‐administered questionnaire, and the study was conducted from January 08 to February 10, 2023. EpiData Version 4.6 for entering the data and STATA Version 14 for analyzing the data were used. A multivariable logistic regression analysis was carried out to identify factors associated with healthcare professionals’ attitudes to using mobile health technology.Results: A total of 415 study participants were included in the study. About 180 (43.4%) respondents had a favorable attitude toward mHealth technology in southwest public hospitals. Master’s degree and above (adjusted odds ratio [AOR]: 3.67; 95% CI: 1.22, 4.10), good knowledge of mobile health technology (AOR: 4.08; 95% CI: 1.35, 5.31), more than 5 years of work experience (AOR: 3.09; 95% CI: 1.76, 5.60), had ICT infrastructure (AOR: 2.70; 95% CI: 1.38, 5.31), had own smart mobile (AOR: 3.67; 95% CI: 3.20, 4.31), and had taken computer‐related training (AOR: 1.96; 95% CI: 1.03, 3.73) were positively associated with healthcare professionals’ attitude to using mobile health technologies in southwest Ethiopia.Conclusions: Overall, healthcare professionals’ attitude to using mobile health technologies in southwest Ethiopia was relatively low. Education level, good knowledge, years of work experience, ICT infrastructure, having a smart mobile, and having taken computer‐related training were significant factors of attitude to using mobile health technologies. Considering these factors could provide insight into developing and adopting mobile health technologies in Ethiopia.
Circulating Tumor DNA Dynamics Reveal KRAS G12C Mutation Heterogeneity and Response to Treatment with the KRAS G12C Inhibitor Divarasib in Solid Tumors
Authors: Choi Yoonha , Dharia Neekesh V. , Jun Tomi , Chang Julie , Royer-Joo Stephanie , Yau Kenneth K. , Assaf Zoe J. , Aimi Junko , Sivakumar Smruthy , Montesion Meagan , Sacher Adrian , LoRusso Patricia , Desai Jayesh , Schutzman Jennifer L. , Shi Zhen ,   and the GO42144 study group
Published: July 2024

Abstract

Purpose:
To inform prognosis, treatment response, disease biology, and KRAS G12C mutation heterogeneity, we conducted exploratory circulating tumor DNA (ctDNA) profiling on 134 patients with solid tumors harboring a KRAS G12C mutation treated with single-agent divarasib (GDC-6036) in a phase 1 study.

Experimental Design:
Plasma samples were collected for serial ctDNA profiling at baseline (cycle 1 day 1 prior to treatment) and multiple on-treatment time points (cycle 1 day 15 and cycle 3 day 1).

Results:
KRAS G12C ctDNA was detectable from plasma samples in 72.9% (43/59) and 92.6% (50/54) of patients with non–small cell lung cancer and colorectal cancer, respectively, the majority of whom were eligible for study participation based on a local test detecting the KRAS G12C mutation in tumor tissue. Baseline ctDNA tumor fraction was associated with tumor type, disease burden, and metastatic sites. A decline in ctDNA level was observed as early as cycle 1 day 15. Serial assessment showed a decline in ctDNA tumor fraction associated with response and progression-free survival. Except for a few cases of KRAS G12C sub-clonality, on-treatment changes in KRAS G12C variant allele frequency mirrored changes in the overall ctDNA tumor fraction.

Conclusions:
Across tumor types, the KRAS G12C mutation likely represents a truncal mutation in the majority of patients. Rapid and deep decline in ctDNA tumor fraction was observed in patients responding to divarasib treatment. Early on-treatment dynamics of ctDNA were associated with patient outcomes and tumor response to divarasib treatment.
A Phase II Study Assessing Long-term Response to Ibrutinib Monotherapy in Recurrent or Refractory CNS Lymphoma
Authors: Grommes Christian , Nandakumar Subhiksha , Schaff Lauren R. , Gavrilovic Igor , Kaley Thomas J. , Nolan Craig P. , Stone Jacqueline , Thomas Alissa A. , Tang Sarah S. , Wolfe Julia , Bozza Alexis , Wongchai Venissala , Hyde Alisson , Barrett Emma , Lynch Elizabeth A. , Madzsar Juli T. , Lin Andrew , Piotrowski Anna F. , Pentsova Elena , Francis Jasmine H. , Hatzoglou Vaios , Schultz Nikolaus , Reiner Anne S. , Panageas Katherine S. , DeAngelis Lisa M. , Mellinghoff Ingo K. 
Published: July 2024

Abstract

Purpose:
Ibrutinib is a first-in-class inhibitor of Bruton tyrosine kinase. We previously reported the safety and short-term antitumor activity of ibrutinib in 20 patients with relapsed or refractory (r/r) primary central nervous system (CNS) lymphoma (PCNSL) or secondary CNS lymphoma (SCNSL).

Patients and Methods:
We enrolled 26 additional patients with r/r PCNSL/SCNSL into the dose-expansion cohort of the trial into a combined cohort of 46 patients (31 with PCNSL and 15 with SCNSL). Patients received ibrutinib at 560 or 840 mg daily in the dose-escalation cohort and ibrutinib at 840 mg daily in the expansion cohort. The median follow-up was 49.9 and 62.1 months for patients with PCNSL and SCNSL, respectively. We sequenced DNA from available tumor biopsies and cerebrospinal fluid collected before and during ibrutinib therapy.

Results:
Tumor responses were observed in 23/31 (74%) patients with PCNSL and 9/15 (60%) patients with SCNSL, including 12 complete responses in PCNSL and 7 in SCNSL. The median progression-free survival (PFS) for PCNSL was 4.5 months [95% confidence interval (CI), 2.8–9.2] with 1-year PFS at 23.7% (95% CI, 12.4%–45.1%). The median duration of response in the 23 PCNSL responders was 5.5 months. The median PFS in SCNSL was 5.3 months (95% CI, 1.3–14.5) with a median duration of response of 8.7 months for the 9 responders. Exploratory biomarker analysis suggests that mutations in TBL1XR1 may be associated with a long-term response to ibrutinib in PCNSL (P = 0.0075). Clearance of ctDNA from cerebrospinal fluid was associated with complete and long-term ibrutinib responses.

Conclusions:
Our study confirms single-agent activity of ibrutinib in r/r CNS lymphoma and identifies molecular determinants of response based on long-term follow-up.
Failure to Rescue After Percutaneous Coronary Intervention: Insights From the National Cardiovascular Data Registry
Authors: Doll Jacob A. , Kataruka Akash , Manandhar Pratik , Wojdyla Daniel M. , Yeh Robert W. , Wang Tracy Y. , Hira Ravi S. 
Published: July 2024

BACKGROUND:
Failure to rescue (FTR) describes in-hospital mortality following a procedural complication and has been adopted as a quality metric in multiple specialties. However, FTR has not been studied for percutaneous coronary intervention (PCI) complications.

METHODS:
This is a retrospective study of patients undergoing PCI from the American College of Cardiology National Cardiovascular Data Registry’s CathPCI Registry between April 1, 2018, and June 30, 2021. PCI complications evaluated were significant coronary dissection, coronary artery perforation, vascular complication, significant bleeding within 48 hours, new cardiogenic shock, and tamponade. Secular trends for FTR were evaluated with descriptive analysis, and hospital-level variation and clinical predictors were analyzed with logistic regression.

RESULTS:

Among 2 196 661 patients undergoing PCI at 1483 hospitals, 3.5% had at least 1 PCI complication. In-hospital mortality occurred more frequently following a complication compared with cases without a complication (19.7% versus 1.3%). FTR increased during the study period from 17.1% to 20.1% (
P
<0.001). The median odds ratio for FTR was 1.48 (95% CI, 1.44–1.53) indicating significant hospital-level variation. Spearman rank correlation demonstrated the modest correlation between FTR and in-hospital mortality, 0.525 (
P
<0.001).

CONCLUSIONS:
Major procedural complications during PCI are infrequent, but FTR occurs in roughly 1 in 5 patients following a PCI procedural complication with significant hospital-level variation. Improved understanding of practices associated with low FTR could meaningfully improve patient outcomes following a PCI complication.
Stroke Risk After Emergency Department Treat-and-Release Visit for a Fall
Authors: Kaiser Jed H. , Zhang Cenai , Kamel Hooman , Navi Babak B. , Razzak Junaid , Liberman Ava L. 
Published: July 2024

BACKGROUND:
Previous cohort studies of hospitalized patients with a delayed diagnosis of ischemic stroke found that these patients often had an initial emergency department (ED) diagnosis of a fall. We sought to evaluate whether ED visits for a fall resulting in discharge to home (ie, treat-and-release visits) were associated with increased short-term ischemic stroke risk.

METHODS:

A case-crossover design was used to compare ED visits for falls during case periods (0–15, 16–30, 31–90, and 91–180 days before stroke) and control periods (equivalent time periods exactly 1 year before stroke) using administrative data from the Healthcare Cost and Utilization Project on all hospital admissions and ED visits across 10 states from 2016 to 2020. To identify ED treat-and-release visits for a fall and patients hospitalized for acute ischemic stroke, we used previously validated
International Classification of Diseases, Tenth Revision, Clinical Modification
codes. Odds ratios and 95% CIs were calculated using conditional logistic regression.

RESULTS:
Among 90 592 hospitalized patients with ischemic stroke, 5230 (5.8%) had an ED treat-and-release visit for a fall within 180 days before their stroke. Patients with an ED treat-and-release visit for a fall were older (mean age, 74.7 [SD, 14.6] versus 70.8 [SD, 15.1] years), more often female (61.9% versus 53.4%), and had higher rates of vascular comorbidities than other patients with stroke. ED treat-and-release visits for a fall were significantly more common in the 15 days before stroke compared with the 15-day control period 1 year earlier (odds ratio, 2.7 [95% CI, 2.4–3.1]). The association between stroke and a preceding ED treat-and-release visit for a fall decreased in magnitude with increasing temporal distance from stroke.

CONCLUSIONS:
ED treat-and-release visits for a fall are associated with significantly increased short-term ischemic stroke risk. These visits may be opportunities to improve stroke diagnostic accuracy and treatment in the ED.
Ten Years of Operating a Center with Large-Scale Virtual-Reality Installations: Developments and Learnings
Authors: Mayer Elisabeth , Hernández Rubén Jesús García , Kolb Daniel , Dreer Jutta , Müller Simone , Odaker Thomas , Kranzlmüller Dieter 
Published: July 2024

Abstract
Virtual reality (VR) can be found in many fields including art history, education, research, and industry 4.0. Next to lightweight head-mounted displays there are also VR installations, such as immersive 3D screens, large-scale displays, and CAVE systems, that are used in research, scientific visualization, and also the automotive industry. These systems offer high visual quality and collaborative VR experiences for researchers and have long been used in research. We present learnings and insights from ten years of operating and maintaining a visualization center with large-scale immersive displays and installations. Our report aims to answer questions on the benefits and challenges of such a location-based VR center. We broke down the ten years into three phases and discuss the installations themselves, software, and other various developments of the center over time, illustrated with exemplary use cases. Finally, we cover our experiences at the beginning of phase four with the installation of a (novel) LED CAVE and the future (forward-looking) developments we expect for location-based VR centers.
TAMU TRACER: Targeted Mobile Measurements to Isolate the Impacts of Aerosols and Meteorology on Deep Convection
Authors: Rapp Anita D. , Brooks Sarah D. , Nowotarski Christopher J. , Sharma Milind , Thompson Seth A. , Chen Bo , Matthews Brianna H. , Etten-Bohm Montana , Nielsen Erik R. , Li Ron 
Published: July 2024

Abstract
Difficulty in using observations to isolate the impacts of aerosols from meteorology on deep convection often stems from the inability to resolve the spatiotemporal variations in the environment serving as the storm’s inflow region. During the U.S. Department of Energy (DOE) Tracking Aerosol Convection interactions Experiment (TRACER) in June–September 2022, a Texas A&M University (TAMU) team conducted a mobile field campaign to characterize the meteorological and aerosol variability in air masses that serve as inflow to convection across the ubiquitous mesoscale boundaries associated with the sea and bay breezes in the Houston, Texas, region. These boundaries propagate inland over the fixed DOE Atmospheric Radiation Measurement (ARM) sites. However, convection occurs on either or both the continental or maritime sides or along the boundary. The maritime and continental air masses serving as convection inflow may be quite distinct, with different meteorological and aerosol characteristics that fixed-site measurements cannot simultaneously sample. Thus, a primary objective of TAMU TRACER was to provide mobile measurements similar to those at the fixed sites, but in the opposite air mass across these moving mesoscale boundaries. TAMU TRACER collected radiosonde, lidar, aerosol, cloud condensation nuclei (CCN), and ice nucleating particle (INP) measurements on 29 enhanced operations days covering a variety of maritime, continental, outflow, and prefrontal air masses. This paper summarizes the TAMU TRACER deployment and measurement strategy, instruments, and available datasets and provides sample cases highlighting differences between these mobile measurements and those made at the ARM sites. We also highlight the exceptional TAMU TRACER undergraduate student participation in high-impact learning activities through forecasting and field deployment opportunities.
Glucagon-like peptide-1 (GLP-1) receptor agonists for headache and pain disorders: a systematic review
Authors: Halloum Wael , Dughem Yousef Al , Beier Dagmar , Pellesi Lanfranco 
Published: July 2024

Abstract
Background
Glucagon-like peptide-1 (GLP-1) plays a crucial role in metabolic disorders by enhancing insulin secretion, inhibiting glucagon release, and slowing gastric emptying, thereby improving glycemic control. In recent years, GLP-1 role in neuronal pathways has expanded its therapeutic potential. We aim to comprehensively evaluate the relevance of GLP-1 in headache and pain disorders.

Methods
A systematic literature search was conducted on PubMed and Embase (Ovid) databases using the search terms “GLP-1” and “pain”. Animal and human studies published in English language were included. Abstracts, reviews, and articles on other disorders than “pain” were excluded.

Results
The search strategy identified 833 hits, of which 42 studies were included in the final review. The studies were categorized into four groups: inflammatory pain and osteoarthritis, headaches, neuropathic pain and diabetic neuropathy, and visceral pain and irritable bowel syndrome. GLP-1 receptor (GLP-1R) agonists, like liraglutide, have shown analgesic effects by modulating pain hypersensitivity in animal models of inflammatory and neuropathic pain. GLP-1 is involved in migraine mechanisms and GLP-1R agonists are beneficial in individuals with idiopathic intracranial hypertension. Additionally, GLP-1R agonists reduce visceral hypersensitivity and ameliorate symptoms in patients with irritable bowel syndrome.

Conclusions
The therapeutic scope of GLP-1R agonists is expanding beyond traditional metabolic targets, highlighting its potential for headache and pain disorders. Engineering bimodal molecules that integrate GLP-1R agonism with specific pain-related mechanisms may offer innovative therapeutic options.
Multimodal training protocols on unstable rather than stable surfaces better improve dynamic balance ability in older adults
Authors: Rizzato Alex , Bozzato Matteo , Rotundo Luca , Zullo Giuseppe , De Vito Giuseppe , Paoli Antonio , Marcolin Giuseppe 
Published: July 2024

Abstract
Background
There has been growing interest in using unstable devices in training protocols. This study aimed to assess the effectiveness of two multimodal exercise interventions (i.e., on stable and unstable surfaces) on dynamic balance control and lower limb strength in older adults.

Methods
Sixty-two older adults were randomly assigned to two intervention groups (N = 20, stable group; N = 19, unstable group), and to a control group (N = 18). In this single-blinded randomized controlled study, the two intervention groups underwent a 12-week training program twice a week for 45 min, consisting of strength and balance exercises. The stable (ST) group performed the training program over stable surfaces, while the unstable (UNST) group over unstable surfaces. Dynamic balance was assessed by computing the center of pressure (CoP) trajectory while a driven movable platform induced an unexpected perturbation of the base of support. Specifically, we considered the following CoP-related parameters within a 2.5-s temporal window from the beginning of the perturbation: displacement (Area95), mean velocity (Unit Path), anterior–posterior first peak (FP), post perturbation variability (PPV), and maximal oscillations (ΔCoPMax). The dominant quadriceps strength was measured through an isometric maximal voluntary contraction on an instrumented chair.

Results
Four out of five CoP-related parameters (i.e., Area95, Unit Path, ΔCoPMax, and PPV) significantly improved in the UNST group from a minimum of 14.28% (d = 0.44) to a maximum of 52.82% (d = 0.58). The ST group significantly improved only in two (i.e., ΔCoPMax, and PPV) out of five CoP-related parameters with an enhancement of 12.48% (d = 0.68) and 19.10% (d = 1.06). Both intervention groups increased the maximal isometric quadriceps strength (UNST:17.27%, d = 0.69; ST:22.29%, d = 0.98). The control group did not show changes in any of the parameters considered.

Conclusions
Stable surfaces promoted faster increments of muscular strength. Unstable surfaces were more effective in enhancing dynamic balance efficiency. These findings suggested the employment of multimodal training on unstable rather than stable surfaces to potentially lower the incidence of falls in older adults.

Trial registration
NCT 05769361, retrospectively registered 13 March 2023, https://clinicaltrials.gov/study/NCT05769361?lat=45.3661864&lng=11.8209139&locStr=Padova,%20Italy&distance=50&page=11&rank=107.