bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis and characteristics of natural fiber reinforced nano hybrid composite – an experimental study
Authors: Vetrivel Kumar K. , Manikanda Prabu N. , Jayanthi Manju , Gurusamy Sureshkannan 
Published: August 2024

AbstractRecently, research on natural hybrid composites has occupied a significant role in the materials science sector. Due to the low density, high specific strength, dimensional stability, and biodegradability, natural fiber composite has become a predominant research area. The present study deals with the fabrication of a jute–banana fiber hybrid composite using the hand layup method with compression molding. A fixed concentration of 5 % carbon nanotubes (CNT) is included over the fiber surfaces as an additional reinforcement material to improve their thermal and electrical conduction properties. The prepared composite material is subjected to different fiber loading (0, 10, 20, and 30 wt.%) with jute and banana weight ratios of 1:1, 1:3, and 3:1. The investigation is conducted for testing the physical, mechanical, and thermal properties of the prepared composites along with morphological studies. Final results revealed a maximum longitudinal tensile strength of 68.8 MPa, 67.0 MPa, and 86.7 MPa and the maximum transverse tensile strength of 41.2 MPa, 40.5 MPa, and 48.0 MPa at 30 wt.% with respective fiber ratio of 1:1, 1:3, and 3:1. The maximum longitudinal flexural strength of this hybrid composite is noticed as 94 MPa, 90 MPa, and 103 MPa for the weight ratio of 1:1, 1:3, and 3:1. Higher impact energy is obtained for the composition ratio of 1:3 (JBC 1:3) which has more banana fiber than the other two. A new attempt at adding carbon nanotubes has improved their thermal conductivity compared to regular composites of jute–banana.
Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study
Authors: Sun Mingze , Zhong Yiming , Li Gaoxiang , Zhao Yichao , Zhang Hengyuan , Yang Xiaoqiu , Yan Xiaoxiang , Chen Alex F. , Pu Jun 
Published: August 2024

Background:Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and certain subtypes of cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs. To determine whether PECAM-1 and CVDs are causally associated, we conducted a two-sample Mendelian randomization (TSMR) study.Methods:Single nucleotide polymorphisms (SNPs) associated with PECAM-1 were used as instrumental variants (IVs) to estimate the causal effects of PECAM-1 on CVDs. Six SNPs were included in our TSMR study. The inverse-variance weighted (IVW) method was applied in the primary analysis. To confirm the initial results, we conducted several complementary analyses and pleiotropy analyses.Results:In the IVW analysis, higher genetically predicted PECAM-1 levels were associated with lower risk of coronary artery disease (CAD) (OR, 0.835; CI, 0.757–0.92; P = 3 × 10−4) and myocardial infarction (MI) (OR, 0.79; CI, 0.709–0.881; P = 2.03 × 10−5).Conclusions:The findings confirmed that elevated PECAM-1 levels may decrease the risk of CAD and MI. These results confirm the causal effect of PECAM-1 on CVDs and may facilitate further investigation of the mechanism of PECAM-1 in CVD pathogenesis.
DMXL2 is required for endocytosis and recycling of synaptic vesicles in auditory hair cells
Authors: Peng Hu , Wang Longhao , Gao Yunge , Liu Huihui , Lin Guotong , Kong Yu , Xu Pengcheng , Liu Hongchao , Yuan Qingyue , Liu Huanhai , Song Lei , Yang Tao , Wu Hao 
Published: August 2024

Ribbon synapses of inner hair cells are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles, however, remains elusive. This study showed that hair cell knockout of murineDmxl2, whose human homolog is responsible for non-syndromic sensorineural hearing loss DFNA71, resulted in auditory synaptopathy by impairing synaptic endocytosis and recycling. The mutant mice in the C57BL/6J background of either sex had mild hearing loss with severely diminished wave-I amplitude of the auditory brainstem response. Membrane capacitance measurements of the inner hair cells revealed deficiency in sustained synaptic exocytosis and endocytic membrane retrieval. Consistent with the electrophysiological findings, 3D electron microscopy reconstruction showed reduced reserve pool of synaptic vesicles and endocytic compartments, while the membrane-proximal and ribbon-associated vesicles remain intact. Our results propose an important role of DMXL2 in hair cell endocytosis and recycling of the synaptic vesicles.Significance StatementThe molecular basis underlying efficient recycling of the ribbon synaptic vesicles in cochlear hair cells remains elusive. In this study, investigation of a hair cell-specific knockout mouse for Dmxl2 identifies its import roles in endocytosis and recycling of the auditory synaptic vesicles. The mutant mice display auditory synaptopathy, a common feature for noise-induced hearing loss and age-related hearing loss. The inner hair cells show deficiency in sustained synaptic exocytosis and endocytic membrane retrieval with reduced reserve pool of synaptic vesicles and endocytic compartments. Our results provide new insights into the molecular machinery ensuring ultrafast and indefatigable neurotransmission of the sound.
The atmospheric water vapor content effect on carbon dioxide and methane radiative forcing in the troposphere and stratosphere
Authors: ФИРСОВ К.М. , ЧЕСНОКОВА Т.Ю. , РАЗМОЛОВ А.А. 
Published: August 2024

Согласно отчету по изменениям климата IPCC-2021 концентрация углекислого газа и метана в атмосфере за последние 50 лет выросла примерно на четверть. Проведены расчеты радиационного возмущающего воздействия (далее – радиационный форсинг) СО2и СН4за счет роста их концентрации для умеренных широт. Вертикальные профили температуры и влажности были взяты согласно данным аэрологического и спутникового зондирования атмосферы. Статистическими методами исследовано влияние перекрывания полос поглощения Н2О с полосами CО2и CH4на результаты расчета радиационного форсинга этих газов в тропосфере и стратосфере умеренных широт при различном содержании водяного пара. Показано, что радиационный форсинг CO2в тропосфере с ростом влагосодержания возрастает по абсолютной величине, тогда как радиационный форсинг СН4не зависит от общего влагосодержания в вертикальном столбе атмосферы. Полученные результаты могут представлять интерес для специалистов, изучающих процессы динамики паров воды в атмосфере и их взаимосвязи с ростом концентрации парниковых газов.
According to the IPCC-2021 Report on climate change, the atmospheric CO2and CH4concentrations have increased by around a quarter for the last 50 years. The CO2 and CH4radiative forcing due to their concentration growth was calculated for mid-latitudes. The vertical profiles of temperature and humidity were taken from the ECMWF ERA-5 European reanalysis data. An impact of overlapping of H2O absorption bands with CO2and CH4bands on the radiative forcing calculation results in the troposphere and stratosphere of mid-latitudes with different water vapor content was investigated by statistical methods. It was shown that absolute value of the CO2 radiative forcing in the troposphere increases with the atmospheric water vapor content, whereas the CH4radiative forcing does not depend on the atmospheric total column water vapor.
Peningkatan Daya Saing Pelaku UMKM Melalui Pelatihan Digitalisasi Akuntansi
Authors: Effendi Bahtiar 
Published: August 2024

Usaha Mikro, Kecil dan Menengah (UMKM) merupakan bentuk usaha yang menjadi penopang dalam kegiatan perekonomian suatu daerah dan menjadi barometer keberhasilan dan keberlanjutan tingkat perekonomian suatu daerah. Namun, tidak sedikit UMKM yang menutup kegiatan usaha mereka karena tidak dapat bertahan terhadap kondisi kesulitan keuangan yang dihadapi. Sebagian besar Pelaku UMKM menghadapi kondisi permasalahan yang sama yakni kurangnya pengetahuan yang memadai perihal akuntansi digital dalam mengelola kegiatan usahanya. Berdasarkan permasalahan yang dialami, alternatif solusi yang ditawarkan adalah melalui kegiatan pelatihan akuntansi digital bagi pelaku UMKM Desa Suradiata, Kabupaten Tangerang. Pelatihan yang dilakukan ini bertujuan untuk mempersiapkan para pelaku UMKM agar mampu bertahan menghadapi kondisi yang susah akibat kesulitan keuangan dalam kegiatan usahanya. Adapun metode pengabdian kepada masyarakat yang dilakukan yakni meliputi: tahap persiapan yang terdiri dari observasi, wawancara dengan kepala desa, penyampaian materi, dan penyuluhan materi; tahap pelaksanaan terdiri dari pelaksanaan kegiatan seminar diawali dengan pendekatan dan pendampingan kepada pelaku usaha; tahap evaluasi evaluasi kegiatan yang telah dilaksanakan. Dari hasil kegiatan pelatihan akuntansi digital yang telah dilakukan, para peserta kegiatan memiliki wawasan dan pandangan baru dan melek digitalisasi akuntansi dalam mengelola pembukuan kegiatan usaha dan memaksimalkan pendapatan yang diterima. Kata kunci— Digitalisasi Akuntansi, UMKM, Pelatihan, Peningkatan Kapasitas Abstract Micro, small and medium enterprises (MSMEs) are a form of business that supports the economic activities of a region and is a barometer of the success and sustainability of a region's economic level. However, a number of MSMEs have stopped their operations because they cannot survive the financial difficulties they are facing. Most MSMEs players face the same problem, namely a lack of sufficient knowledge of digital accounting when managing their business activities. Based on the issues encountered, the alternative solution offered is digital accounting training activities for MSMEs in Suradiata Village, Tangerang Regency. The aim of this training is to prepare MSMEs stakeholders to overcome difficult conditions due to financial difficulties in their operations. Community service methods include: Preparatory phase, consisting of observation, interviews with village leaders, delivery of materials and advice on materials; The implementation phase consists of conducting seminar activities, starting with addressing and supporting economic actors. Evaluation phase Assessment of the activities carried out. Based on the results of the digital accounting training conducted, the participants of the activity have gained new insights and views and are familiar with the digitalization of accounting to manage the accounting of business activities and maximize the revenue generated. Keywords— Digitization of Accounting, MSMEs, Training, Capacity Improvement
Loyalty in the French 17th Century Erudite Discourse
Authors: Terenteva Ekaterina 
Published: August 2024

The formation of new bonds of loyalty in early Modern France, which were supposed to connect representatives of the noble estate of the kingdom directly to the figure of the monarch, bypassing traditional patron-client ties, reflected itself in the writings of French scholars. Institutionally connected with the French crown through the positions of historiographers and geographers at the royal court, as well as by their positions in the public service as officials and lawyers, the French erudites bore and expressed the ideology of the strengthening the French absolutism. Various genealogies and extensive genealogical histories of French noble families composed by the erudites were connected with the process of clarifying the boundaries of the noble estate, as well as with promoting an idea of loyalty to the crown as a highest value. Since the turn of the sixteenth and 17th centuries, the figure of the monarch in erudite treatises within the context of the idea of loyalty became increasingly abstract, names of the particular kings having almost completely disappeared from the dedications of erudite works. At the same time, the idea of loyalty to France as a whole was gaining strength, while France in itself was also designated as the “fatherland” (patrie) and was perceived not only as a unity of territories, but above all as a set of institutions and people. In addition to loyalty to a depersonalized homeland and to the more and more abstract figure of French monarch, a different kind of loyalty emerged in the 17th century erudite discourse, as the one which focused on the personalities of statesmen who often headed the institutions to which the authors of the corresponding works belonged. The service of these persons for the glory of France and the French crown was particularly emphasized. The topics of erudite writings ranging from the history of the various French institutions, the French monarchy and the French church to positions, dignities and titles, from the French language to the material remnants of French history (“antiquities”) also directed the reader’s mind to the idea of service and loyalty towards France. However, the formation of the idea of loyalty in the French erudite discourse was of dual and ambivalent nature. On the one hand, it is impossible to deny the trend of developing loyalty of a depersonalized nature, focused primarily on France and the French monarchy. On the other hand, the dedications of the erudite writings make it obvious that there was a network of personal connections of the erudites with leading statesmen of the era, who were often at the same time both their superiors in the service and patrons of their intellectual pursuits. These statesmen may be considered as personifications of the institutions of the same extraterritorial France, to which the loyalty of the French scholars has largely belonged.
ANALISIS PERTIMBANGAN HAKIM PENGADILAN AGAMA SELONG DALAM MEMUTUSKAN PERKARA WALI ADHAL KARENA FAKTOR ADAT (Studi Atas Putusan No.1104/Pdt.P/2022/PA.Sel)
Authors: Imron Hadi  , Achmad Hasan alfarisi  
Published: August 2024

Keberadaan seorang wali dalam pernikahan merupakan syarat sahnya pernikahan itu sendiri. Namun tidak jarang wali nikah menjadi kendala dalam pernikahan karena wali nikah yang utama enggan menjadi wali nikah dengan berbagai alasan, baik syar’i maupun non syar’i. Wali yang menolak menikahkan disebut adhal (enggan). Mempelai wanita berhak mengajukan permohonan ke Pengadilan Agama untuk mengangkat wali adhal. Hal di atas memunculkan masalah penelitian ini. Pertama, Bagaimanakah prosedur penanganan perkara wali adhal yang dilatari faktor adat di Pengadilan Agama Selong? Kedua, Bagaimanakah pertimbangan hakim dalam memutuskan perkara wali adhal karena faktor adat di Pengadilan Agama Selong? Dalam penelitian ini peneliti menggunakan penelitian kualitatif dengan mengumpulkan data melalui wawancara, observasi dan dokumentasi. Dimana sumber data yang digunakan dalam penelitian ini yaitu sumber data primer dan sumber data sekunder. Data primernya dari pihak Hakim, dan Staff Pengadilan Agama sedangkan sekunder dari buku-buku, al-Quran, al-Hadist, skripsi, tesis dan perundang-undangan.Hasil penelitian ini menunjukkan bahwa tata cara prosedur penanganan petugas adhal di Pengadilan Agama Kelas 1B Selong sudah sesuai dengan Hukum Acara Perdata yang dituangkan dalam HIR yaitu.Pertama, pihak harus mendatangi meja Informasi dan Pengaduan diri untuk mengetahui persyaratan permohonan wali adhal. Kedua, ke meja pendaftaran perkara untuk mendaftarkan perkara secara langsung atau melalui online. Ketiga meja pembayaran dengan menyerahkan slip pembayaran dari bank. Keempat, ke meja Penyerahan Produk Pengadilan . Adapun Pertimbangan hakim dalam penetapan wali adhal di Pengadilan Agama Selong, hakim dalam pertimbangannya berdasarkan fakta-fakta di dalam persidangan, berdasarkan sisi kemaslahatan dikarenakan faktor adat dan menurut Hakim alasan wali tidak dibenarkan.
Preinjury and Event-Related Characteristics of Pediatric Firearm Injuries: The American College of Surgeons Firearm Study, United States, March 2021‒February 2022
Authors: Flynn-O’Brien Katherine T. , Sathya Chethan , Kotagal Meera , Banks Samantha , Agoubi Lauren L. , Kuhls Deborah A. , Nathens Avery , Hink Ashley B. , Rivara Frederick P. 
Published: August 2024

Objectives. To assess differences in contextual factors by intent among pediatric firearm injury patients and determine factors associated with data missingness. Methods. We retrospectively queried the American College of Surgeons Firearm Study database (March 1, 2021–February 28, 2022) for patients aged 18 years or younger. We stratified preinjury, firearm-related, and event-related factors by intent and compared them by using Fisher exact, χ2, or 1-way analysis of variance testing. Secondary analysis estimated the adjusted odds of missingness by using generalized linear modeling with binominal logit link. Results. Among 17 395 patients, 2974 (17.1%) were aged 18 years or younger; 1966 (66.1%) were injured by assault, 579 (19.5%) unintentionally, and 76 (2.6%) by self-inflicted means. Most contextual factors differed by intent, including proportion of youths with previous adverse childhood experiences, mental illness, and violent assaults or injury, firearm type and access, perpetrator relationship, and injury location. In adjusted analyses, age, trauma center designation, intent, and admission status were associated with missingness. Conclusions. Contextual factors related to pediatric firearm injury vary by intent. Specific predictors associated with missingness may inform improved future data collection. Public Health Implications. Contextual factors related to pediatric firearm injury can be obtained in a systematic manner nationally to inform targeted interventions. ( Am J Public Health. 2024;114(10):1097–1109. https://doi.org/10.2105/AJPH.2024.307754 )
Axillary Artery Injury Associated with Dislocated or Displaced Proximal Humeral Fracture
Authors: Mitsuzawa Sadaki , Yamashita Shinnosuke , Tsukamoto Yoshihiro , Takeuchi Hisataka , Ota Satoshi , Onishi Eijiro , Yasuda Tadashi 
Published: August 2024

Case:
(1) A 69-year-old man sustained a proximal humeral fracture-dislocation. During emergency surgery, copious bleeding occurred. A pseudoaneurysm was identified 30 days postoperatively. (2) A 69-year-old man sustained a proximal humeral fracture and axillary artery injury. Physical examination demonstrated a cold but pink hand. Hemiarthroplasty and bypass vein grafting were performed. (3) An 86-year-old woman sustained a proximal humeral fracture and axillary artery injury. Her hand had turned cold and pale. Reverse shoulder arthroplasty and bypass vein grafting were performed.

Conclusion:
In cases of proximal humeral fractures with significant displacement, concomitant axillary artery injury must be assessed and if there is a high index of suspicion, prompt advanced imaging is necessary.
Applicability of fatigue design recommendations for thin plate welded joints by assessment of fatigue crack initiation and propagation life
Authors: Kanna Sohei , Takanashi Masahiro 
Published: August 2024

Abstract

Fatigue design guidelines for welded joints are primarily based on tests of around 10mm thick joints. Fatigue strength generally decreases with increased thickness, likely due to increased stress concentration or changes in stress distribution. Thus, guidelines correct and reduce the fatigue strength of thicker joints. However, for thinner plates commonly used in railway cars, there is limited test data and it is unclear if the guidelines apply. This study conducted a 4-point bending fatigue test on a 3mm thick fillet welded joint to determine fatigue strength. Contrary to expectations, fatigue strength decreased when thickness reduced from 9mm to 3mm. However, test results showed higher fatigue strength than the recommended value, confirming that the guidelines can apply to 3mm thickness. Additionally, the study investigated the reduced fatigue strength of thin plates using the relationship between the number of cycles to crack initiation, local stress range, and crack growth analysis based on Paris' law. It found that as thickness decreases, the stress concentration at the weld toe decreases and the number of cycles to crack initiation increases. However, the ligament also shrinks, resulting in a shorter crack propagation life.
A Lumped Parameter Modelling Study of Idiopathic Intracranial Hypertension: Does the CSF Formation Rate vary with the Capillary Transmural Pressure?
Authors: Bateman Grant Alexander , Bateman Alexander Robert 
Published: August 2024

Abstract

Studies simultaneously measuring the intracranial pressure (ICP) and sagittal sinus pressures in idiopathic intracranial hypertension (IIH), suggest either a reduction in the CSF outflow resistance or the CSF formation rate. A study maintaining the ICP at zero showed a significantly elevated CSF formation rate. The purpose of this study is to define the most feasible explanation for these findings. A lumped parameter model originally developed to study normal pressure hydrocephalus was extended to investigate IIH. The model was used to estimate the CSF formation rate and the capillary transmural pressure (TMP), utilizing the data from 4 experiments published within the literature. When the CSF formation rates of these 4 studies were plotted against the estimated capillary transmural pressures, a straight line with an R2 of 0.999 was returned. The model suggests the CSF formation rate in IIH varies with the capillary TMP. A reduced capillary TMP secondary to a reduced blood flow in IIH moderates the ICP. The variation in formation rate is most likely a function of the blood brain barrier (BBB) breakdown known to occur in this disease. Drugs which stabilize the BBB may trigger IIH.
The Physical Therapy Efficacy Index and Chart: a stimulus for value-based healthcare using real-world data. A mixed methods study
Authors: Kiers Henri , Felius Richard A.W. , Heijmans Martijn W. , Verburg Arie C. 
Published: August 2024

Abstract

Background
Health care costs are rising rapidly in Western societies. Understanding the benefits and costs of care is crucial to maintaining or improving existing health care systems. We propose an instrument that provides a clear overview of both the costs and returns of a treatment to improve the quality of care while keeping the costs affordable.
Methods
First, a general value-based healthcare concept was developed as an efficacy index. Second, a Physiotherapy-specific Efficacy Index (PE-Index) for musculoskeletal disorders was formulated based on pain and functional improvement, treatments, and episode duration. The PE-Index 's discriminative value was assessed using a linear mixed model with physiotherapy practices as a random effect in real-world data from a national registry. Variation attributed to practices was quantified by an intraclass correlation coefficient. Separate linear mixed models and a radar plot (PE-Graph) visualized individual PE-Index components. Lastly, stakeholders evaluated the PE-Index and PE-Graph for internal quality improvement and external transparency through surveys and advisory board meetings.
Results
In total, 95.805 episodes treated in 370 practices were included in the linear mixed models. The PE-Index demonstrated an adequate discriminative ability with an ICC of 0.118.
Stakeholders agree that the PE-Index and the PE-Chart are appropriate for improvement of quality of care and enhancing the current system for external transparency. Nevertheless, because of concerns about a too hasty implementation and the risk of strategic gaming, both were not considered suitable for external transparency right now.
Conclusions
The PE-Index and PE-Graph are adequate instruments to discriminate between practices and can be used for internal quality improvement, however, are not yet suitable for external transparency purposes.