bluuebunny/crossref_metadata_2025_split huggingface dataset:
L’éthique professionnelle peut-elle se penser au singulier ? Le cas des formations dans le secteur de l’aide à la personne dépendante
Authors: Demont Guillaume 
Published: August 2013

Nos travaux de recherche portent sur la pluralité des postures et logiques professionnelles à l’œuvre dans les métiers, ce que nous appelons des « moments professionnels ». Cet article montre comment ces moments professionnels s’articulent les uns aux autres dans la pratique, à travers l’exemple d’une activité professionnelle dans le secteur de l’aide à la personne dépendante. À partir de la définition que Paul Ricœur donne de l’éthique, nous observons que cette pluralité de postures et logiques professionnelles conduit à une pluralité des éthiques professionnelles en présence.À partir de là, comment penser la place de l’éthique dans une formation de français à visée professionnelle ? Comment l’éthique peut-elle devenir une composante à part entière de la langue-culture professionnelle, lorsqu’elle est enseignée à partir de récits personnels ? Comment enseigner une éthique du soignant en même temps qu’une éthique de l’éducateur ?
Fermeture résidentielle et politiques urbaines, le cas marseillais
Authors: Dorier Elisabeth , Berry-Chikhaoui Isabelle , Bridier Sébastien 
Published: August 2013

La fermeture résidentielle à Marseille se caractérise par son intensité (presque 20 % du total des logements de la commune) et son emprise spatiale très forte dans certains quartiers (plus de 40 % de leur surface urbanisée). Issu d’une recherche de 3 ans et d’un rapport de recherche remis au PUCA en 2010 (« La diffusion des ensembles résidentiels fermés à Marseille. Les urbanités d’une ville fragmentée »), l’article propose d’enrichir la lecture des processus complexes du cloisonnement résidentiel en s’attachant, d’une part, aux effets de contextes géohistoriques, particulièrement aux héritages fonciers (temps long de la production des espaces urbains) et, d’autre part, aux synergies actuelles entre une action municipale orientée vers l’attractivité territoriale et une offre immobilière spéculative. La multiplication des partenariats publics-privés semble ici dissoudre le fameux dualisme identifié par Mangin (2004) entre « urbanisme de produit » et « urbanisme de projet ».
Les ensembles d’habitat individuel fermés en Ile-de-France. Des morphologies surprenantes, à l’encontre des images supposées
Authors: Loudier-Malgouyres Céline 
Published: August 2013

Face aux inquiétudes ambiantes sur la montée de la fermeture résidentielle, l’étude présentée ici a cherché à mesurer la production récente des ensembles d’habitat individuel fermés en Ile-de-France. Les résultats sont surprenants ; ils montrent un phénomène tout à fait mineur sur le plan quantitatif et des formes plutôt bien intégrées à leur environnement urbain, participant même à l’effort actuel de densification urbaine. Face à ces ensembles fermés, et au-delà des inquiétudes liées aux valeurs de ces figures, quelles sont les questions qui se posent aux collectivités locales en termes d’aménagement et de gestion de leur territoire ? Sans réellement contribuer au modèle redouté de ville fermée et sécurisée, ces formes urbaines, rigides et faiblement mutables, tendent en effet à figer le tissu urbain et à peser d’un poids non négligeable dans la gestion communale.
Exercise Intolerance in Individuals With Postconcussion Syndrome
Authors: Kozlowski Karl F. , Graham James , Leddy John J. , Devinney-Boymel Lee , Willer Barry S. 
Published: August 2013

Context:
Little is known about exercise intolerance or the utility of an exercise evaluation in patients with postconcussion syndrome (PCS).

Objective:
To assess exercise intolerance in male and female patients with PCS.

Design:
Cross-sectional study.

Setting:
Laboratory setting.

Patients or Other Participants:
Participants included a convenience sample of 34 patients with PCS (17 males, 17 females; age = 25.9 ± 10.9 years) and 22 uninjured individuals on whom we gathered historical deidentified laboratory data (control group; 11 males, 11 females; age = 23.3 ± 6.2 years).

Main Outcome Measure(s):
Self-reported symptoms, heart rate, systolic and diastolic blood pressures (BPs), and the Borg rating of perceived exertion were measured before, during each minute of, and immediately after a graded treadmill exercise test (Balke protocol). Exercise was stopped when participants could no longer maintain the effort or reported the onset of or increase in PCS symptoms.

Results:
Exercise test duration (8.5 ± 4.4 minutes versus 17.9 ± 3.6 minutes; t51 = 1.8, P &lt; .001), heart rate (142.8 ± 24.1 versus 175.2 ± 17.4; t54 = −5.5, P &lt; .001), and systolic BP (142.1 ± 18.3 mm Hg versus 155.5 ± 24.5 mm Hg; t53 = 2.3, P = .02) were lower, and diastolic BP (78.4 ± 10.2 mm Hg versus 73.5 ± 11.7 mm Hg; t53 = 2.2, P = .03) was higher at test cessation in the PCS than control group. Cox regression showed the odds of a shorter exercise duration were nearly 8 times greater in the PCS than control group (hazard ratio = 7.93; 95% confidence interval = 3.39, 18.56). In the general linear models that adjusted for differences in test duration, rating of perceived exertion was the only physiologic measure to show an overall difference between groups, with the control group reporting higher ratings than the PCS group (t53 = −6.0, P &lt; .001). Within the PCS group, systolic BP was the only measure to show a sex effect, with males showing higher pressure readings than females throughout the exercise tests (t31 = 2.8, P = .009).

Conclusions:
Patients with PCS had a symptom-limited response to exercise, and the treadmill test was a potentially useful tool to monitor the recovery from PCS.
Differences in Lateral Drop Jumps From an Unknown Height Among Individuals With Functional Ankle Instability
Authors: Rosen Adam , Swanik Charles , Thomas Stephen , Glutting Joseph , Knight Christopher , Kaminski Thomas W. 
Published: August 2013

Context:
Functional ankle instability (FAI) is a debilitating condition that has been reported to occur after 20% to 50% of all ankle sprains. Landing from a jump is one common mechanism of ankle injury, yet few researchers have explored the role of visual cues and anticipatory muscle contractions, which may influence ankle stability, in lateral jumping maneuvers.

Objective:
To examine muscle-activation strategies between FAI and stable ankles under a lateral load and to evaluate the differences in muscle activation in participants with FAI and participants with stable ankles when they were unable to anticipate the onset of lateral loads during eyes-open versus eyes-closed conditions.

Design:
Case-control study.

Setting:
Controlled laboratory setting.

Patients or Other Participants:
A total of 40 people participated: 20 with FAI and 20 healthy, uninjured, sex- and age-matched persons (control group).

Intervention(s):
Participants performed a 2-legged lateral jump off a platform onto a force plate set to heights of 35 cm or 50 cm and then immediately jumped for maximal height. They performed jumps in 2 conditions (eyes open, eyes closed) and were unaware of the jump height when their eyes were closed.

Main Outcome Measure(s):
Amplitude normalized electromyographic (EMG) area (%), peak (%), and time to peak in the tibialis anterior (TA), peroneus longus (PL), and lateral gastrocnemius (LG) muscles were measured.

Results:
Regardless of the eyes-open or eyes-closed condition, participants with FAI had less preparatory TA (t158 = 2.22, P = .03) and PL (t158 = 2.09, P = .04) EMG area and TA (t158 = 2.45, P = .02) and PL (t158 = 2.17, P = .03) peak EMG than control-group participants.

Conclusions:
By removing visual cues, unanticipated lateral joint loads occurred simultaneously with decreased muscle activity, which may reduce dynamic restraint capabilities in persons with FAI. Regardless of visual impairment and jump height, participants with FAI exhibited PL and TA inhibition, which may limit talonavicular stability and intensify lateral joint surface compression and pain.
Challenges of locally manufactured vehicle supply chains in South Africa
Authors: Ambe Intaher M. , Badenhorst-Wess Johanna A. 
Published: August 2013

Locally manufactured vehicles are destined (partly) for the export market and thus, global competitiveness is important. This article explores the challenges facing supply chains of locally manufactured vehicles in South Africa. The automotive industry is perceived to be the most advanced in supply chain management practices in South Africa. It has embraced technology and management practices that have transformed the manufacturing environment by using cutting-edge design and visualisation tools. However, the industry has fragilities and faces new and emerging supply chain challenges. A survey research design was employed and the data was collected through face-to-face semi-structured interview questionnaires based on the purposive sampling technique. Data analysis and interpretation was based on descriptive statistics using SPSS software. The findings revealed that there are challenges hindering best supply chain practices of local vehicle manufacturers. The research also revealed that there is a perceived difference in supply chain challenges between the different manufacturers of different origins in South Africa. Asian manufacturers felt much stronger about the adequacy of their information systems compared to the European manufacturers. Asian manufacturers tended to agree more than their European counterparts that labour problems were a challenge. European manufacturers, on the other hand, tended to agree more that rail transport is unreliable. This article contributes to the body of knowledge on supply chain practices in South Africa.
Esophagobronchial fistulae: Diagnosis by MDCT with oral contrast swallow examination of a benign and a malignant cause
Authors: Hegde Rahul G , Kalekar Tushar M , Gajbhiye Meenakshi I , Bandgar Amol S , Pawar Shephali S , Khadse Gopal J 
Published: August 2013

AbstractWe report two cases of esophagobronchial fistulae diagnosed by Multi-detector computed tomography (MDCT) oral contrast swallow examination. It is helpful to supplement the CT study with an oral contrast swallow as it aids in confirmation of a suspected fistula and also demonstrates the fistula tract better. We present the clinical details and the imaging findings on MDCT of two cases of esophagobronchial fistulae - one secondary to chronic chest tuberculosis and the other secondary to a squamous cell carcinoma of the upper esophagus - followed by discussion of the etiology, pathogenesis, and imaging of these fistulae.
Role of radiofrequency ablation in unresectable hepatocellular carcinoma: An Indian experience
Authors: Kalra Naveen , Kang Mandeep , Bhatia Anmol , Duseja Ajay K , Dhiman Radha K , Arya Virendra K , Rajwanshi Arvind , Chawla Yogesh K , Khandelwal Niranjan 
Published: August 2013

Abstract
Aims: To evaluate the role of radiofrequency ablation (RFA) as an ablative technique in patients with unresectable hepatocellular carcinoma (HCC). Settings and Design: A tertiary care center, prospective study. Materials and Methods: The subjects comprised 31 patients (30 males, one female; age range 32-75 years) with HCC (41 lesions) who were treated with image-guided RFA. The follow-up period ranged from 3 months to 6 years, and included a multiphasic computed tomography (CT) at 1, 3 and 6 months post-RFA, and every 6 months thereafter. Patient outcome was evaluated and the tumor recurrence, survival and complications were assessed. Statistical Analysis Used: Discrete categorical data were presented as n (%) and continuous data as mean ± SD. Pearson correlation coefficient was used to determine the relationship between the different variables. Kaplan-Meier survival curve and Log-rank test were used to test the significance of difference between the survival time of the different groups. Results: The ablation success rate was 80.5% (33/41 HCC lesions). 12.2% (5/41) of the lesions were managed with repeat RFA due to tumor residue. 4.9% (2/41) of the lesions were managed with repeated RFA and transarterial chemoembolization. Eight patients had tumor recurrence (five patients (16.1%) had local recurrence and three patients (9.6%) had distant recurrence). Eleven patients died within 3.5-20 months post-RFA. The survival rate at 1 year in patients who completed at least 1 year of follow-up was 63.3%. There was one major complication (1/31, 3.2%) in a patient with a subcapsular lesion and ascites. This patient developed hemoperitoneum in the immediate postprocedure period and was managed with endovascular treatment. She, however, had hepatic decompensation and died 48 h post-RFA. Conclusion: RFA is an effective and safe treatment for small unresectable HCC.
5q31.3 Microdeletion syndrome: Clinical and molecular characterization of two further cases
Authors: Brown Natasha , Burgess Trent , Forbes Robin , McGillivray George , Kornberg Andrew , Mandelstam Simone , Stark Zornitza 
Published: August 2013

ABSTRACTThe 5q31.3 microdeletion syndrome has recently emerged as a distinct clinical entity, and we report two new patients with de novo deletions of this region, bringing the total to seven. Similarly to previously reported cases, the phenotype of our patients is characterized by marked hypotonia, apnea, developmental delay, and feeding difficulties. Both patients had abnormal movements which did not correlate with epileptiform activity on electroencephalogram (EEG). Developmental brain changes on neuroimaging consisted of abnormalities predominantly affecting the white matter and frontal lobes. The 5q31.3 deleted regions overlap those of previously reported cases, and allow further refinement of the shortest region of overlap to 101 kb, including only three genes. Of these, the purine‐rich element binding protein A (PURA) gene has an established role in brain development, and we propose that haploinsufficiency for this gene is primarily responsible for the neurodevelopmental features observed. © 2013 Wiley Periodicals, Inc.
JAG1 Mutation in a patient with deletion 22q11.2 syndrome and tetralogy of Fallot
Authors: Digilio Maria Cristina , Luca Alessandro De , Lepri Francesca , Guida Valentina , Ferese Rosangela , Dentici Maria Lisa , Angioni Adriano , Marino Bruno , Dallapiccola Bruno 
Published: August 2013

AbstractDeletion 22q11.2 (del22q11.2) syndrome, also known as DiGeorge/Velo‐cardio‐facial syndrome (DG/VCFS), and Alagille syndrome are genetic disorders characteristically associated with congenital heart defects (CHDs). We report on a patient with tetralogy of Fallot (TOF) and clinical features of DG/VCFS, hemizygous for del22q11.2 and heterozygous for the 2810G > A (p.Arg937Gln) mutation in the JAG1 gene associated with Alagille syndrome. The clinical features of del22q11.2 syndrome are present in the patient, including facial anomalies, typical TOF, speech delay with hypernasal voice, and learning difficulties. TOF and mild hepatic involvement, consisting of slightly elevated aminotransferase conjugated bilirubin levels, were the only features of Alagille syndrome in our patient. The anatomic type of TOF displayed no distinctive recognizable pattern for either DG/VCFS or Alagille syndrome. It is likely that hemizygosity of the TBX1 gene was causally related to TOF in this patient, although a synergistic pathogenic role of the JAG1 gene mutation in causing the heart defect cannot be excluded. JAG1 mutations have been previously detected in patients with nonsyndromic TOF and recent molecular evidence supports the cumulative effect of multiple genetic defects in the etiology of human malformations. We hypothesize that a similar mechanism could be present in this patient with del22q11.2 syndrome associated with a JAG1 missense mutation acting as possible modifier factor for TOF. © 2013 Wiley Periodicals, Inc.
The identification of MAFB mutations in eight patients with multicentric carpo–tarsal osteolysis supports genetic homogeneity but clinical variability
Authors: Mehawej Cybel , Courcet Jean‐Benoît , Baujat Geneviève , Mouy Richard , Gérard Marion , Landru Isabelle , Gosselin Morgane , Koehrer Philippe , Mousson Christiane , Breton Sylvain , Quartier Pierre , Le Merrer Martine , Faivre Laurence , Cormier‐Daire Valérie 
Published: August 2013

AbstractMulticentric carpo–tarsal osteolysis (MCTO) with or without nephropathy is a rare osteolysis disorder beginning in early childhood and involving mainly carpal and tarsal bones. Renal disease appears later in life in the majority of cases and evolves quickly to end stage renal failure. Autosomal dominant (AD) inheritance has been demonstrated, with a high frequency of sporadic cases. Recently, mutations in a highly conserved region of the MAFB gene (v‐maf musculoaponeurotic fibrosarcoma oncogene ortholog B) have been identified in MCTO patients by exome sequencing. MafB, known as a regulator of various developmental processes, is essential for osteoclastogenesis and renal development. We report here the molecular screening of MAFB in eight MCTO patients from six families. We identified MAFB mutations in all, including three novel missense mutations clustering within the hot spot mutation region. Among the eight patients, six only presented renal disease. Our report confirms the genetic homogeneity of MCTO and provides data underlying the clinical variability of this disorder. © 2013 Wiley Periodicals, Inc.
Severe congenital lipodystrophy and a progeroid appearance: Mutation in the penultimate exon of FBN1 causing a recognizable phenotype
Authors: Takenouchi Toshiki , Hida Mariko , Sakamoto Yoshiaki , Torii Chiharu , Kosaki Rika , Takahashi Takao , Kosaki Kenjiro 
Published: August 2013

AbstractRecently, three marfanoid patients with congenital lipodystrophy and a neonatal progeroid appearance were reported. Although their phenotype was distinct from that of classic Marfan syndrome, they all had a truncating mutation in the penultimate exon, i.e., exon 64, of FBN1, the causative gene for Marfan syndrome. These patients might represent a new entity, but the exact phenotypic and genotypic spectrum remains unknown. Here, we report on a girl born prematurely who exhibited severe congenital lipodystrophy and a neonatal progeroid appearance. The patient exhibited a characteristic growth pattern consisting of an accelerated growth in height with a discrepant poor weight gain. She had a characteristic facial appearance with craniosynostosis. A mutation analysis identified c.8175_8182del8bp, p.Arg2726Glufs*9 in exon 64 of the FBN1 gene. A review of similar, recently reported patients revealed that the cardinal features of these patients include (1) congenital lipodystrophy, (2) premature birth with an accelerated linear growth disproportionate to the weight gain, and (3) a progeroid appearance with distinct facial features. Lines of molecular evidence suggested that this new progeroid syndrome represents a neomorphic phenotype caused by truncated transcripts with an extremely charged protein motif that escapes from nonsense‐mediated mRNA decay, altering FBN1‐TGF beta signaling, rather than representing the severe end of the hypomorphic phenotype of the FBN1‐TGF beta disorder spectrum. We propose that this marfanoid entity comprised of congenital lipodystrophy, a neonatal progeroid appearance, and a peculiar growth profile and caused by rare mutations in the penultimate exon of FBN1, be newly referred to as marfanoid–progeroid syndrome. © 2013 Wiley Periodicals, Inc.
Neurological deficits caused by tissue hypoxia in neuroinflammatory disease
Authors: Davies Andrew L. , Desai Roshni A. , Bloomfield Peter S. , McIntosh Peter R. , Chapple Katie J. , Linington Christopher , Fairless Richard , Diem Ricarda , Kasti Marianne , Murphy Michael P. , Smith Kenneth J. 
Published: August 2013

ObjectiveTo explore the presence and consequences of tissue hypoxia in experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).MethodsEAE was induced in Dark Agouti rats by immunization with recombinant myelin oligodendrocyte glycoprotein and adjuvant. Tissue hypoxia was assessed in vivo using 2 independent methods: an immunohistochemical probe administered intravenously, and insertion of a physical, oxygen‐sensitive probe into the spinal cord. Indirect markers of tissue hypoxia (eg, expression of hypoxia‐inducible factor‐1α [HIF‐1α], vessel diameter, and number of vessels) were also assessed. The effects of brief (1 hour) and continued (7 days) normobaric oxygen treatment on function were evaluated in conjunction with other treatments, namely administration of a mitochondrially targeted antioxidant (MitoQ) and inhibition of inducible nitric oxide synthase (1400W).ResultsObserved neurological deficits were quantitatively, temporally, and spatially correlated with spinal white and gray matter hypoxia. The tissue expression of HIF‐1α also correlated with loss of function. Spinal microvessels became enlarged during the hypoxic period, and their number increased at relapse. Notably, oxygen administration significantly restored function within 1 hour, with improvement persisting at least 1 week with continuous oxygen treatment. MitoQ and 1400W also caused a small but significant improvement.InterpretationWe present chemical, physical, immunohistochemical, and therapeutic evidence that functional deficits caused by neuroinflammation can arise from tissue hypoxia, consistent with an energy crisis in inflamed central nervous system tissue. The neurological deficit was closely correlated with spinal white and gray matter hypoxia. This realization may indicate new avenues for therapy of neuroinflammatory diseases such as MS. Ann Neurol 2013;74:815–825
Nitrergic Neurons in the Spinal Cord of the Bottlenose Dolphin (Tursiops truncatus)
Authors: Bombardi Cristiano , Grandis Annamaria , Gardini Anna , Cozzi Bruno 
Published: August 2013

ABSTRACTNitric oxide (NO) is a freely diffusible gaseous neurotransmitter generated by a selected population of neurons and acts as a paracrine molecule in the nervous system. NO is synthesized from l‐arginine by means of the neuronal nitric oxide synthase (nNOS), an enzyme requiring nicotine adenine dinucleotide phosphate (NADPH) as cofactor. In this study, we used histochemical and immunohistochemical techniques to investigate the distribution of NADPH‐diaphorase (NADPH‐d) and nNOS in the spinal cord of the bottlenose dolphin (Tursiops truncatus). Cells with a fusiform‐shaped somata were numerous in the laminae I and II. The intermediolateral horn showed darkly‐stained cells with a multipolar morphology. Neurons with a multipolar or fusiform morphology were observed in the ventral horn. Multipolar and fusiform neurons were the most common cell types in lamina X. Nitrergic fibers were numerous especially in the dorsal and intermediolateral horns. The presence of nitrergic cells and fibers in different laminae of the spinal cord suggests that NO may be involved in spinal sensory and visceral circuitries, and potentially contribute to the regulation of the complex retia mirabilia. Anat Rec, 296:1603–1614, 2013. © 2013 Wiley Periodicals, Inc.