bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Effect of Hip Abductor Muscle Fatigue on Frontal Plane Knee Projection Angle During Step Landing
Authors: Herrington Lee 
Published: June 2014

Context:A number of acute and overuse knee pathologies share a mechanism involving a poor dynamic alignment of the limb creating increased stress in the tissues. Inappropriate execution of a correct strategy during landing has been suggested to involve insufficient activity of the hip abductor and external rotator muscles. Limited data describing the relationships between hip-abductor muscle fatigue and hip/knee joint mechanics exists.Objective:To investigate the effect of fatigue of the hip abductor muscles on knee valgus angle.Design:Repeated measures.Participants:30 asymptomatic subjects: 15 female (age 20.4 ± 1.4, range 18–26 years; height 1.66 m, range 1.60–1.76 m; weight 63.9 kg, range 58–68 kg) and 15 male subjects (age 22 ± 3.2, range 18–28 years; height 1.84 m, range 1.65–1.90 m; weight 82.1 kg, range 69–93 kg).Main outcome Measures:Knee valgus (frontal plane projection) angle was assessed during a step landing task before and following a fatiguing protocol of the hip abductor muscles involving repeated 10 s maximal isometric contractions of the hip abductor muscles, until strength was recorded as 50% of preintervention score.Results:Males showed no significant change in knee valgus angle at initial ground contact (p = .9 ES 0.1) or in maximum knee valgus (p = .64 ES 0.5) following the fatiguing. Females showed a significant increase in maximum knee valgus angle following the fatiguing (p = .0018 ES 1.0), though the knee valgus angle at initial contact was not changed (p = .12 ES 0.67). They also demonstrated a significant increase in the change in knee valgus angle between initial contact and maximum following the fatiguing (p = .0004 ES 0.88).Conclusion:Females appear more susceptible to the effects of hip muscle fatigue, leading to a detrimental change in landing kinematics which may then predispose them to knee injury.
The Effect of Trial Duration on Single-Limb Stance Postural Control Measures
Authors: Powden Cameron , Hoch Matthew 
Published: June 2014

Context:Currently, there are limited guidelines for the trial duration of quiet single-limb postural control tests. However, trial duration may influence the results of postural control assessments.Objective:To examine the effect of trial duration on instrumented measures of postural control in healthy adults.Design:Cross-sectional.Setting:Laboratory.Patients or Other Participants:Ten healthy adults (eight females, two males; age = 22.1 ± 1.5 years; 167.4 ± 9.3 cm; 67.4 ± 12.3 kg).Interventions:Static postural control was assessed using quiet single-limb stance on a force plate. With eyes open and closed, participants stood barefoot on one limb. Instructions were stand with hands on hips and remain as motionless as possible. A practice trial was performed before the collection of three 10 s trials on each limb for each visual condition. The data collected during each trial were analyzed as the initial 2.5 s, the initial 5 s, and 10 s.Main outcome Measures:The independent variables included vision, limb, and trial duration. The dependent variables included postural control examined using time-to-boundary (TTB) variables: mean of TTB minima (TTB-M) and the standard deviation of TTB minima (TTB-SD) in the anterior-posterior (AP) and medial-lateral (ML) directions.Results:No significant 3-way or 2-way interactions or limb main effects were identified. Main effects were identified for vision and trial duration in all TTB variables. Post hoc analysis revealed significant differences between all trial durations in all TTB variables.conclusions:Greater TTB values were exhibited during the 10 s trial durations compared with 5 s and 2.5 s, and 5 s trial durations compared with 2.5 s, indicating postural control improved with longer trial durations. This suggests differing aspects of postural control may be examined with different trial durations.
Genome Sequence of
Streptomyces olindensis
DAUFPE 5622, Producer of the Antitumoral Anthracycline Cosmomycin D
Authors: Rojas Juan D. , Starcevic Antonio , Baranas̆ić Damir , Ferreira-Torres Maria A. , Contreras Camilo A. , Garrido Leandro M. , Araújo Welington L. , de Souza Robson F. , Zucko Jurica , Hranueli Daslav , Long Paul F. , Cullum John , Padilla Gabriel 
Published: June 2014

ABSTRACT

Streptomyces olindensis
DAUFPE 5622, which was isolated from a Brazilian soil sample, produces the antitumor anthracycline cosmomycin D. The genome sequence is 9.4 Mb in length, with a G+C content of 71%. Thirty-four putative secondary metabolite biosynthetic gene clusters were identified, including the cosmomycin D cluster.
Draft Genome Sequence of Enterotoxigenic Escherichia coli Strain W25K
Authors: Ren Wenkai , Liu Gang , Yin Jie , Chen Shuai , Li Tiejun , Kong Xiangfeng , Peng Yuanyi , Yin Yulong , Hardwidge Philip R. 
Published: June 2014

ABSTRACT

Enterotoxigenic
Escherichia coli
(ETEC) is a major cause of diarrheal disease in humans and newly weaned pigs. Here, we report the draft genome sequence of ETEC strain W25K, which causes diarrhea in piglets.
Draft Genome Sequence of Kozakia baliensis SR-745, the First Sequenced
Kozakia
Strain from the Family
Acetobacteraceae
Authors: Schmid Jochen , Koenig Steven , Pick André , Steffler Fabian , Yoshida Shosuke , Miyamoto Kenji , Sieber Volker 
Published: June 2014

ABSTRACT

Kozakia baliensis
belongs to the family
Acetobacteraceae
and was described for the first time in 2002. These acetic acid bacteria are able to produce acetic acid from various carbon sources and 2- and 5-keto-
d
-gluconate from glucose. The novel
K. baliensis
strain SR-745 was isolated from a pineapple fruit bought in a German supermarket. The strain produces large amounts of organic acids when grown on glucose-containing medium and accepts also glycerol, fructose, mannitol, and sucrose as a C source. When grown under light and high-oxygen conditions in submerged culture, the production of a pink pigment is observed after 72 h.
Draft Genome Sequence of Entomopathogenic Serratia liquefaciens Strain FK01
Authors: Taira Erika , Iiyama Kazuhiro , Mon Hiroaki , Mori Kazuki , Akasaka Taiki , Tashiro Kousuke , Yasunaga-Aoki Chisa , Lee Jae Man , Kusakabe Takahiro 
Published: June 2014

ABSTRACT

In the present study, we determined the draft genome sequence of the entomopathogenic bacterium
Serratia liquefaciens
FK01, which is highly virulent to the silkworm. The draft genome is ~5.28 Mb in size, and the G+C content is 55.8%.
Complete Genome Sequences of Two Prolific Biofilm-Forming Staphylococcus aureus Isolates Belonging to USA300 and EMRSA-15 Clonal Lineages
Authors: Sabirova J. S. , Xavier B. B. , Hernalsteens J.-P. , De Greve H. , Ieven M. , Goossens H. , Malhotra-Kumar S. 
Published: June 2014

ABSTRACT

Methicillin-resistant
Staphylococcus aureus
(MRSA) causes serious infections that are even more difficult to treat when associated with a biofilm phenotype that facilitates evasion of the host immune system and antibiotics. As a first step toward understanding the mechanisms underlying biofilm formation, we sequenced the genomes of two prolific biofilm-forming strains belonging to the two most important globally disseminated clonal lineages, USA300 and EMRSA-15.
Genome Sequence of Thermophilic Bacillus licheniformis Strain 3F-3, an Efficient Pentose-Utilizing Producer of 2,3-Butanediol
Authors: Li Lixiang , Wang Yu , Wang Kai , Li Kun , Ma Cuiqing , Xu Ping 
Published: June 2014

ABSTRACT

Bacillus licheniformis
strain 3F-3 is an efficient pentose-utilizing producer of platform chemical, 2,3-butanediol. Here we present a 4.1-Mb assembly of its genome. The key genes for pentose utilization, regulation, and metabolism of 2,3-butanediol were annotated, which may provide further insights into the molecular mechanism of 2,3-butanediol production from biomass pentose.
Scaling up integrated prevention campaigns for global health: costs and cost-effectiveness in 70 countries
Authors: Marseille Elliot , Jiwani Aliya , Raut Abhishek , Verguet Stéphane , Walson Judd , Kahn James G 
Published: June 2014

ObjectiveThis study estimated the health impact, cost and cost-effectiveness of an integrated prevention campaign (IPC) focused on diarrhoea, malaria and HIV in 70 countries ranked by per capita disability-adjusted life-year (DALY) burden for the three diseases.MethodsWe constructed a deterministic cost-effectiveness model portraying an IPC combining counselling and testing, cotrimoxazole prophylaxis, referral to treatment and condom distribution for HIV prevention; bed nets for malaria prevention; and provision of household water filters for diarrhoea prevention. We developed a mix of empirical and modelled cost and health impact estimates applied to all 70 countries. One-way, multiway and scenario sensitivity analyses were conducted to document the strength of our findings. We used a healthcare payer's perspective, discounted costs and DALYs at 3% per year and denominated cost in 2012 US dollars.Primary and secondary outcomesThe primary outcome was cost-effectiveness expressed as net cost per DALY averted. Other outcomes included cost of the IPC; net IPC costs adjusted for averted and additional medical costs and DALYs averted.ResultsImplementation of the IPC in the 10 most cost-effective countries at 15% population coverage would cost US$583 million over 3 years (adjusted costs of US$398 million), averting 8.0 million DALYs. Extending IPC programmes to all 70 of the identified high-burden countries at 15% coverage would cost an adjusted US$51.3 billion and avert 78.7 million DALYs. Incremental cost-effectiveness ranged from US$49 per DALY averted for the 10 countries with the most favourable cost-effectiveness to US$119, US$181, US$335, US$1692 and US$8340 per DALY averted as each successive group of 10 countries is added ordered by decreasing cost-effectiveness.ConclusionsIPC appears cost-effective in many settings, and has the potential to substantially reduce the burden of disease in resource-poor countries. This study increases confidence that IPC can be an important new approach for enhancing global health.
Assessment of impact of a novel infectious bursal disease (IBD) vaccination programme in breeders on IBD humoral antibody levels through the laying period
Authors: Parker Daniel , de Wit Sjaak , Houghton Helen , Prandini Francesco 
Published: June 2014

ObjectivesThe purpose of this study was to assess whether broiler breeders vaccinated in ovo with a Vaxxitek (HVT&IBD) (Merial) plus an inactivated IBD vaccine prior to the onset of lay had a significantly different humoral IBD antibody response to broiler breeders vaccinated solely with Vaxxitek (HVT&IBD) (Merial) in ovo. In addition, maternally derived antibody (MDA) passed to the progeny of these two breeders flocks was also compared at three time points during lay.DesignThe study was a case–control study where the two flocks were the same breed, reared on the same farm and transferred to the same laying farm, the only difference between the flocks being the IBD vaccination programme. The humoral IBD antibody response in the flocks and their progeny was measured using two commercial ELISA tests and a serum neutralisation (SN) test.ResultsThere was no significant difference (P<0.05) in the humoral IBD antibody response in the two breeder flocks as measured by ELISA test except at a single time point at 22 weeks when measured by BioChek ELISA and at 60 weeks when measured by IDEXX ELISA. There was no significant difference (P<0.05) in the humoral IBD antibody response in the two breeder flocks as measured by SN test except at 27 and 55 weeks. There was no significant difference (P<0.05) in the levels of MDA passed to progeny of these two breeder flocks as measured by ELISA or SN test.ConclusionsIt is proposed that a single vaccination with Vaxxitek (HVT&IBD) (Merial) will provide a similar level of IBD protection to breeders and their progeny as a Vaxxitek (HVT&IBD) (Merial) plus inactivated IBD vaccine, vaccination programme. This novel IBD vaccine provides additional options for vaccination programmes for broiler breeders without impacting on the protection of the broiler progeny.
AR-Regulated TWEAK-FN14 Pathway Promotes Prostate Cancer Bone Metastasis
Authors: Yin JuanJuan , Liu Yen-Nien , Tillman Heather , Barrett Ben , Hewitt Stephen , Ylaya Kris , Fang Lei , Lake Ross , Corey Eva , Morrissey Colm , Vessella Robert , Kelly Kathleen 
Published: June 2014

Abstract
The recurrence of prostate cancer metastases to bone after androgen deprivation therapy is a major clinical challenge. We identified FN14 (TNFRSF12A), a TNF receptor family member, as a factor that promotes prostate cancer bone metastasis. In experimental models, depletion of FN14 inhibited bone metastasis, and FN14 could be functionally reconstituted with IKKβ-dependent, NFκB signaling activation. In human prostate cancer, upregulated FN14 expression was observed in more than half of metastatic samples. In addition, FN14 expression was correlated inversely with androgen receptor (AR) signaling output in clinical samples. Consistent with this, AR binding to the FN14 enhancer decreased expression. We show here that FN14 may be a survival factor in low AR output prostate cancer cells. Our results define one upstream mechanism, via FN14 signaling, through which the NFκB pathway contributes to prostate cancer metastasis and suggest FN14 as a candidate therapeutic and imaging target for castrate-resistant prostate cancers. Cancer Res; 74(16); 4306–17. ©2014 AACR.
High-Throughput Time-Resolved FRET Reveals Akt/PKB Activation as a Poor Prognostic Marker in Breast Cancer
Authors: Veeriah Selvaraju , Leboucher Pierre , de Naurois Julien , Jethwa Nirmal , Nye Emma , Bunting Tamara , Stone Richard , Stamp Gordon , Calleja Véronique , Jeffrey Stefanie S. , Parker Peter J. , Larijani Banafshé 
Published: June 2014

Abstract
Dysregulation of the Akt/PKB pathway has been associated with poor prognosis in several human carcinomas. Current approaches to assess Akt activation rely on intensity-based methods, which are limited by the subjectivity of manual scoring and poor specificity. Here, we report the development of a novel assay using amplified, time-resolved Förster resonance energy transfer (FRET), which is highly specific and sensitive and can be adapted to any protein. Using this approach to analyze primary breast tissue microarrays, we quantified levels of activated pAkt at a spatial resolution that revealed molecular heterogeneity within tumors. High pAkt status assessed by amplified FRET correlated with worse disease-free survival. Our findings support the use of amplified FRET to determine pAkt status in cancer tissues as candidate biomarker for the identification of high-risk patients. Cancer Res; 74(18); 4983–95. ©2014 AACR.
Plasma Neutrophil Gelatinase-Associated Lipocalinin in the General Population
Authors: Lindberg Søren , Jensen Jan S. , Mogelvang Rasmus , Pedersen Sune H. , Galatius Søren , Flyvbjerg Allan , Magnusson Nils E. 
Published: June 2014

Objective—
Neutrophil gelatinase-associated lipocalin (NGAL) is a glycoprotein stored in granules of neutrophil leukocytes participating in inflammatory and atherosclerotic processes and possibly plaque rupture. Despite the putative role of NGAL in atherosclerosis and acute myocardial infarction, human studies of plasma NGAL are still limited.

Approach and Results—

We prospectively followed 5599 randomly selected men and women from the community in the fourth Copenhagen Heart Study. Plasma NGAL was measured at study entry. Participants were followed for 10 years. During follow-up, 20% died (n=1120) and 15% (n=884) developed a major adverse cardiovascular event. Plasma NGAL associated strongly with all inflammatory markers (high-sensitivity C-reactive protein, total leukocyte count, neutrophil count) and inversely with estimated glomerular filtration rate (all,
P
<0.001). Multivariate analysis identified neutrophil leukocyte count as the main determinant of plasma NGAL. During follow-up, participants with increasing NGAL had increased risk of all-cause mortality and major adverse cardiovascular event (both,
P
<0.001). Even after adjustment for confounding risk factors by Cox regression analysis, NGAL remained an independent predictor of both all-cause mortality and major adverse cardiovascular event. When added to the Framingham risk score, NGAL improved
c
-statistics and correctly reclassified ≈15% into more appropriate risk groups. In comparison with high-sensitivity C-reactive protein, when both markers were added to the Framingham risk score, NGAL conferred 3× to 4× the risk.

Conclusions—

Plasma NGAL is strongly associated with inflammation in the general population. NGAL independently associated with 10-year outcome, and when added to the Framingham risk score, NGAL both improves
c
-statistics and correctly reclassifies participants into more accurate risk categories.
Diagnostic Value of Isoproterenol Testing in Arrhythmogenic Right Ventricular Cardiomyopathy
Authors: Denis Arnaud , Sacher Frédéric , Derval Nicolas , Lim Han. S. , Cochet Hubert , Shah Ashok J. , Daly Matthew , Pillois Xavier , Ramoul Khaled , Komatsu Yuki , Zemmoura Adlane , Amraoui Sana , Ritter Philippe , Ploux Sylvain , Bordachar Pierre , Hocini Mélèze , Jaïs Pierre , Haïssaguerre Michel 
Published: June 2014

Background—
Although the Task Force Criteria for arrhythmogenic right ventricular cardiomyopathy (ARVC) have recently been updated, the diagnosis remains challenging in the early stages. The aim of this study was to evaluate the diagnostic value of β-adrenergic stimulation in ARVC.

Methods and Results—

We evaluated 412 consecutive patients (213 men, age 41.5±16 years) referred for premature ventricular contractions evaluation or suspected ARVC. Isoproterenol testing was performed with continuous infusion of isoproterenol (45 μg/min) for 3 minutes. It was considered positive if there were either (1) polymorphic premature ventricular contractions with ≥1 couplet or (2) sustained or nonsustained ventricular tachycardia with left bundle branch block excluding right ventricular outflow tract ventricular tachycardia. ARVC was diagnosed in 35 patients at initial evaluation (23 men, aged 42±15 years). Isoproterenol testing was positive in 32 of 35 (91.4%) patients with ARVC and in 42 of 377 (11.1%) patients without ARVC (
P
<0.0001). Sensitivity, specificity, positive, and negative predictive values of isoproterenol testing to diagnose ARVC were 91.4%, 88.9%, 43.2%, and 99.1%, respectively. During a mean follow-up period of 5.6±4.4 years, 6 additional patients met diagnostic criteria for ARVC. Importantly, initial isoproterenol testing was positive in 6 of 6 (100%) of these patients. Survival free from ARVC diagnosis was significantly lower in the positive isoproterenol group than in the negative isoproterenol group (
P
<0.0001, exact log-rank test).

Conclusions—
Ventricular arrhythmogenicity during isoproterenol testing is highly sensitive (sensitivity, 91.4%) for the diagnosis of ARVC, particularly in its early stages.
Predicting the Risk of Venous Thromboembolism in Patients Hospitalized With Heart Failure
Authors: Mebazaa Alexandre , Spiro Theodore E. , Büller Harry R. , Haskell Lloyd , Hu Dayi , Hull Russell , Merli Geno , Schellong Sebastian W. , Spyropoulos Alex C. , Tapson Victor F. , De Sanctis Yoriko , Cohen Alexander T. 
Published: June 2014

Background—
Whether heart failure (HF) increases the risk of venous thromboembolism (VTE) is not well established. In the phase III MAGELLAN (Multicenter, rAndomized, parallel Group Efficacy and safety study for the prevention of venous thromboembolism in hospitalized medically iLL patients comparing rivaroxabAN with enoxaparin) trial, extended-duration rivaroxaban was compared with standard-duration enoxaparin followed by placebo for VTE prevention in 8101 hospitalized acutely ill patients with or without HF. The aim of this analysis was to evaluate the relationship between HF severity and the risk of VTE in MAGELLAN patients.

Methods and Results—

Hospitalized patients diagnosed with HF were included according to New York Heart Association class III or IV at admission (n=2593). HF severity was determined by N-terminal probrain natriuretic peptide (NT-proBNP) plasma concentrations (median 1904 pg/mL). Baseline plasma D-dimer concentrations ranged from 0.6 to 1.7 μg/L for the less and more severe HF subgroups. Patients with more severe HF had a greater incidence of VTE versus patients with less severe HF, with a significant trend up to Day 10 (4.3% versus 2.2%;
P
=0.0108) and Day 35 (7.2% versus 4.1%;
P
=0.0150). Multivariable analysis confirmed that NT-proBNP concentration was associated with VTE risk up to Day 10 (
P
=0.017) and D-dimer concentration with VTE risk up to Day 35 (
P
=0.005). The association between VTE risk and HF severity that was observed in the enoxaparin/placebo group was not seen in the extended-duration rivaroxaban group.

Conclusions—
Patients with more severe HF, as defined by high NT-proBNP plasma concentration, were at increased risk of VTE. NT-proBNP may be useful to identify high short-term risk, whereas elevated D-dimer may be suggestive of high midterm risk.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT00571649.
PERSIANN-CDR: Daily Precipitation Climate Data Record from Multisatellite Observations for Hydrological and Climate Studies
Authors: Ashouri Hamed , Hsu Kuo-Lin , Sorooshian Soroosh , Braithwaite Dan K. , Knapp Kenneth R. , Cecil L. Dewayne , Nelson Brian R. , Prat Olivier P. 
Published: June 2014

Abstract
A new retrospective satellite-based precipitation dataset is constructed as a climate data record for hydrological and climate studies. Precipitation Estimation from Remotely Sensed Information using Artificial Neural Networks–Climate Data Record (PERSIANN-CDR) provides daily and 0.25° rainfall estimates for the latitude band 60°S–60°N for the period of 1 January 1983 to 31 December 2012 (delayed present). PERSIANN-CDR is aimed at addressing the need for a consistent, long-term, high-resolution, and global precipitation dataset for studying the changes and trends in daily precipitation, especially extreme precipitation events, due to climate change and natural variability. PERSIANN-CDR is generated from the PERSIANN algorithm using GridSat-B1 infrared data. It is adjusted using the Global Precipitation Climatology Project (GPCP) monthly product to maintain consistency of the two datasets at 2.5° monthly scale throughout the entire record. Three case studies for testing the efficacy of the dataset against available observations and satellite products are reported. The verification study over Hurricane Katrina (2005) shows that PERSIANN-CDR has good agreement with the stage IV radar data, noting that PERSIANN-CDR has more complete spatial coverage than the radar data. In addition, the comparison of PERSIANN-CDR against gauge observations during the 1986 Sydney flood in Australia reaffirms the capability of PERSIANN-CDR to provide reasonably accurate rainfall estimates. Moreover, the probability density function (PDF) of PERSIANN-CDR over the contiguous United States exhibits good agreement with the PDFs of the Climate Prediction Center (CPC) gridded gauge data and the Tropical Rainfall Measuring Mission (TRMM) Multi-Satellite Precipitation Analysis (TMPA) product. The results indicate high potential for using PERSIANN-CDR for long-term hydroclimate studies in regional and global scales.