bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peri-implant phenotype, calprotectin and MMP-8 levels in cases diagnosed with peri-implant disease
Authors: Önder Yasemin Beliz , Alpaslan Nazli Zeynep 
Published: June 2024

Abstract
Objectives
The purpose of this prospective cohort study is to evaluate the effect of peri-implant phenotype (PPh) on the severity of peri-implant diseases and the results of non-surgical mechanical treatment (NSMT), along with calprotectin (CLP) and MMP-8(matrix metalloproteinase-8) levels.

Materials and methods
77 implants from 39 patients were included. The implants were categorized Group-1(peri-implant mucositis), Group-2(peri-implantitis).Baseline (0. Month-PrT) clinical parameters (PD, GI, PI, BOP, CAL) and radiographic bone loss were documented, and peri-implant crevicular fluid (PICF) samples were collected. Various intruments and methodologies were employed to assess PPh components (mucosa thickness, supracrestal tissue height, keratinized mucosa) and peri-implant attached mucosa (AM). NSMT was applied to diseased implant sites. All clinical parameters were reassessed again by taking PICF samples at the 6th month-after treatment (PT). In PICF samples obtained from both groups, MMP-8 and CLP levels were evaluated using the ELISA test.

Results
PrT-PD,PrT-GI,PrT-CAL and PrT-BOP percentage values in Group-2 were significantly higher than Group-1.PrT-PD,PrTPI scores are significantly higher in thin biotype implants. All components of the PPh and AM were significantly lower in thin biotype. Intra-group time-dependent changes of MMP-8 and CLP were significant in both groups (p < 0.05). When the relationship between thin and thick biotype and biochemical parameters was evaluated, the change in PrT-PT didn’t show a significant difference (p > 0.05).

Conclusions
PPh plays a role in influencing the severity of peri-implant diseases. However, the impact of phenotype on NSMT outcomes was similar in both groups.

Clinical relevance
The PPh should be considered when planning implant surgery.
The extracellular matrix protein EMILIN-1 impacts on the microenvironment by hampering gastric cancer development and progression
Authors: Capuano Alessandra , Vescovo Maddalena , Canesi Simone , Pivetta Eliana , Doliana Roberto , Nadin Maria Grazia , Yamamoto Masami , Tsukamoto Tetsuya , Nomura Sachiyo , Pilozzi Emanuela , Palumbo Antonio , Canzonieri Vincenzo , Cannizzaro Renato , Scanziani Eugenio , Baldassarre Gustavo , Mongiat Maurizio , Spessotto Paola 
Published: June 2024

Abstract
Background
The contribution of the tumor microenvironment and extracellular matrix to the aggressive biology of Gastric Cancer (GC) has been recently characterized; however, the role of EMILIN-1 in this context is unknown. EMILIN-1 is an essential structural element for the maintenance of lymphatic vessel (LV) integrity and displays anti-proliferative properties as demonstrated in skin and colon cancer. Given the key role of LVs in GC progression, the aim of this study was to investigate the role of EMILIN-1 in GC mouse models.

Methods
We used the syngeneic YTN16 cells which were injected subcutaneously and intraperitoneally in genetically modified EMILIN-1 mice. In alternative, carcinogenesis was induced using N-Methyl-N-nitrosourea (MNU). Mouse-derived samples and human biopsies were analyzed by IHC and IF to the possible correlation between EMILIN-1 expression and LV pattern.

Results
Transgenic mice developed tumors earlier compared to WT animals. 20 days post-injection tumors developed in EMILIN-1 mutant mice were larger and displayed a significant increase of lymphangiogenesis. Treatment of transgenic mice with MNU associated with an increased number of tumors, exacerbated aggressive lesions and higher levels of LV abnormalities. A significant correlation between the levels of EMILIN-1 and podoplanin was detected also in human samples, confirming the results obtained with the pre-clinical models.

Conclusions
This study demonstrates for the first time that loss of EMILIN-1 in GC leads to lymphatic dysfunction and proliferative advantages that sustain tumorigenesis, and assess the use of our animal model as a valuable tool to verify the fate of GC upon loss of EMILIN-1.
Predicting EGFR Status After Radical Nephrectomy or Partial Nephrectomy for Renal Cell Carcinoma on CT Using a Self-attention-based Model: Variable Vision Transformer (vViT)
Authors: Usuzaki Takuma , Inamori Ryusei , Ishikuro Mami , Obara Taku , Takaya Eichi , Homma Noriyasu , Takase Kei 
Published: June 2024

Abstract
Objective
To assess the effectiveness of the vViT model for predicting postoperative renal function decline by leveraging clinical data, medical images, and image-derived features; and to identify the most dominant factor influencing this prediction.

Materials and Methods
We developed two models, eGFR10 and eGFR20, to identify patients with a postoperative reduction in eGFR of more than 10 and more than 20, respectively, among renal cell carcinoma patients. The eGFR10 model was trained on 75 patients and tested on 27, while the eGFR20 model was trained on 77 patients and tested on 24. The vViT model inputs included class token, patient characteristics (age, sex, BMI), comorbidities (peripheral vascular disease, diabetes, liver disease), habits (smoking, alcohol), surgical details (ischemia time, blood loss, type and procedure of surgery, approach, operative time), radiomics, and tumor and kidney imaging. We used permutation feature importance to evaluate each sector's contribution. The performance of vViT was compared with CNN models, including VGG16, ResNet50, and DenseNet121, using McNemar and DeLong tests.

Results
The eGFR10 model achieved an accuracy of 0.741 and an AUC-ROC of 0.692, while the eGFR20 model attained an accuracy of 0.792 and an AUC-ROC of 0.812. The surgical and radiomics sectors were the most influential in both models. The vViT had higher accuracy and AUC-ROC than VGG16 and ResNet50, and higher AUC-ROC than DenseNet121 (p < 0.05). Specifically, the vViT did not have a statistically different AUC-ROC compared to VGG16 (p = 1.0) and ResNet50 (p = 0.7) but had a statistically different AUC-ROC compared to DenseNet121 (p = 0.87) for the eGFR10 model. For the eGFR20 model, the vViT did not have a statistically different AUC-ROC compared to VGG16 (p = 0.72), ResNet50 (p = 0.88), and DenseNet121 (p = 0.64).

Conclusion
The vViT model, a transformer-based approach for multimodal data, shows promise for preoperative CT-based prediction of eGFR status in patients with renal cell carcinoma.
Reconciling Coulter Counter and laser diffraction particle size analysis for aquaculture monitoring
Authors: Milligan T. G. , Law B. A. , Zions V. , Hill P. S. , Hua K. , McKindsey C. W. , Lacoursière‐Roussel A. 
Published: June 2024

AbstractThe disaggregated inorganic grain size (DIGS) of bottom sediment analyzed with a Coulter Counter (CC) has been used to show that the fraction of sediment deposited in flocs (floc fraction) increased in both the near and far field after the introduction of open cage salmon aquaculture, altering benthic habitat and species composition. As a result, DIGS was identified as a potential indicator of regional environmental changes due to aquaculture. Laser diffraction is an attractive alternative to the CC because of its greater efficiency and larger size range. To determine if a laser diffraction instrument, Beckman-Coulter LS 13 320 (LS), could replace the CC within a Canadian national aquaculture monitoring program, the DIGS of 581 samples from five different regions in eastern Canada were analyzed with an LS and a CC. Results show that the LS could not be used to calculate floc fraction. Instead, % sortable silt and the volume % of inorganic particles < 16 µm were evaluated as alternative proxies for fine sediment properties. LS and CC values for these parameters were correlated, but they were significantly different and the relationship between the instruments was dependent on the area sampled. The LS did not capture variations between areas seen in the CC DIGS data. Where the DIGS from the CC found no sorting in the finest size classes, all the LS samples had similar size distributions characterized by smooth modal peaks. The LS and CC both return values that can be used to monitor changes in the deposition of fine-grained sediment, but the LS cannot determine changes in floc deposition and caution is required if comparing different sedimentary environments.
Plasma H3Cit-DNA Discriminates Between Cancer and Inflammation in a Cohort of Patients with Unspecific Cancer Symptoms
Authors: Wannberg Fredrika , Hjalmar Viktoria , Ng Henry , Johansson Caroline , Probert Fay , Phillipson Mia , Åberg Mikael , Gordon Max , Mackman Nigel , Rosell Axel , Thålin Charlotte 
Published: June 2024

Abstract
Cancer detection is challenging, especially in patients with unspecific cancer symptoms. Biomarkers could identify patients at high risk of cancer. Prior studies indicate that neutrophil extracellular traps (NETs) are associated with cancer, but also with autoimmune and infectious diseases. The objective of this prospective study was to investigate markers associated with NET formation (nucleosomal citrullinated histone 3 [H3Cit-DNA], cell free DNA [cfDNA] and neutrophil elastase [NE]), and c-reactive protein (CRP) in patients with unspecific cancer symptoms, such as fatigue, weight loss or radiological sign of malignancy without an apparent primary tumor, referred to the Diagnostic Center at Danderyd Hospital in Sweden. Blood samples were drawn on admission, before cancer diagnosis. Out of 475 patients, 160 (34%) were diagnosed with cancer, 56 (12%) with autoimmune disease, 32 (7%) with infectious disease, 71 (15%) with other diseases and 156 (33%) received no diagnosis. H3Cit-DNA, cfDNA, NE and CRP were significantly higher in patients with cancer compared to patients without cancer (p < 0.0001, p < 0.0001, p = 0.004, and p = 0.0002 respectively). H3Cit-DNA, but not cfDNA, NE or CRP, was significantly elevated in patients with cancer compared to patients with autoimmune disease (p = 0.0001). H3Cit-DNA, cfDNA, NE or CRP did not differ between cancer and infectious disease. In conclusion, H3Cit-DNA is elevated in patients diagnosed with cancer compared to non-cancer patients with the same symptomatology. Further studies should evaluate if H3Cit-DNA could aid in selecting patients that would benefit the most from a rapid cancer diagnostic work-up.
Graphical Abstract
Racial Differences in the Prevalence of Autism Spectrum Disorder: A Systematic Review
Authors: Gallin Zachary , Kolevzon Ana M. , Reichenberg Abraham , Hankerson Sidney H. , Kolevzon Alexander 
Published: June 2024

Abstract
Purpose
Racial differences in prevalence rates of autism spectrum disorder (ASD) have shifted in the United States (US) since the 1990s. This review addresses the nature and context of this shift and discusses potential contributing factors and areas for future research.

Methods
Seventeen population-based epidemiological birth cohort studies on ASD prevalence in the US that included race as a variable are included in the review. Studies were identified via a keyword search on PubMed. To be included, studies were required to include race or ethnicity as a variable in the prevalence estimates, include at least 1000 cases with autism, and be published in English by June 3rd, 2023.

Results
Results suggest that in nearly all birth cohorts prior to 2010, ASD prevalence rates were highest among White children. ASD prevalence rates among Black, Hispanic, and Asian/Pacific Islander (API) children (22.3, 22.5, and 22.2 per 1000, respectively) surpassed prevalence rates among White children (21.2 per 1000) in the 2010 birth cohort and continued to increase in the 2012 birth cohorts.

Conclusions
There are persistent racial differences in ASD prevalence in the US, and these differences were inverted after 2010, when ASD prevalence among Black, Hispanic, & API children surpassed ASD prevalence among White children. Possible drivers of this racial repatterning of ASD prevalence include changes in ASD screening and diagnosis, changes to health insurance policy, changes to immigration policy, and increased education attainment by minority groups.
Knowledge Graph-Aware Deep Interest Extraction Network on Sequential Recommendation
Authors: Wang Zhenhai , Xu Yuhao , Wang Zhiru , Fan Rong , Guo Yunlong , Li Weimin 
Published: June 2024

AbstractSequential recommendation is the mainstream approach in the field of click-through-rate (CTR) prediction for modeling users’ behavior. This behavior implies the change of the user’s interest, and the goal of sequential recommendation is to capture this dynamic change. However, existing studies have focused on designing complex dedicated networks to capture user interests from user behavior sequences, while neglecting the use of auxiliary information. Recently, knowledge graph (KG) has gradually attracted the attention of researchers as a structured auxiliary information. Items and their attributes in the recommendation, can be mapped to knowledge triples in the KG. Therefore, the introduction of KG to recommendation can help us obtain more expressive item representations. Since KG can be considered a special type of graph, it is possible to use the graph neural network (GNN) to propagate the rich information contained in the KG into the item representation. Based on this idea, this paper proposes a recommendation method that uses KG as auxiliary information. The method first propagates the knowledge information in the KG using GNN to obtain a knowledge-rich item representation. Then the temporal features in the item sequence are extracted using a transformer for CTR prediction, namely the Knowledge Graph-Aware Deep Interest Extraction network (KGDIE). To evaluate the performance of this model, we conducted extensive experiments on two real datasets with different scenarios. The results showed that the KGDIE method could outperform several state-of-the-art baselines. The source code of our model is available at https://github.com/gylgyl123/kgdie.
The forward-backward-forward algorithm with extrapolation from the past and penalty scheme for solving monotone inclusion problems and applications
Authors: Tongnoi Buris 
Published: June 2024

AbstractIn this paper, we consider an improved iterative method for solving the monotone inclusion problem in the form of $$0 \in A(x) + D(x) + N_{C}(x)$$

0
∈
A

(
x
)

+
D

(
x
)

+

N
C

(
x
)

in a real Hilbert space, where A is a maximally monotone operator, D and B are monotone and Lipschitz continuous, and C is the nonempty set of zeros of the operator B. We investigate the weak ergodic and strong convergence (when A is strongly monotone) of the iterates produced by our considered method. We show that the algorithmic scheme can also be applied to minimax problems. Furthermore, we discuss how to apply the method to the inclusion problem involving a finite sum of compositions of linear continuous operators by using the product space approach and employ it for convex minimization. Finally, we present a numerical experiment in TV-based image inpainting to validate the proposed theoretical theorem.
The indexation of retracted literature in seven principal scholarly databases: a coverage comparison of dimensions, OpenAlex, PubMed, Scilit, Scopus, The Lens and Web of Science
Authors: Ortega José Luis , Delgado-Quirós Lorena 
Published: June 2024

AbstractIn this study, the coverage and overlap of retracted publications, retraction notices and withdrawals are compared across seven significant scholarly databases, with the aim to check for discrepancies, pinpoint the causes of those discrepancies, and choose the best product to produce the most accurate picture of retracted literature. Seven scholarly databases were searched to obtain all the retracted publications, retraction notices and withdrawal from 2000. Only web search interfaces were used, excepting in OpenAlex and Scilit. The findings demonstrate that non-selective databases (Dimensions, OpenAlex, Scilit, and The Lens) index a greater amount of retracted literature than do databases that rely their indexation on venue selection (PubMed, Scopus, and WoS). The key factors explaining these discrepancies are the indexation of withdrawals and proceeding articles. Additionally, the high coverage of OpenAlex and Scilit could be explained by the inaccurate labeling of retracted documents in Scopus, Dimensions, and The Lens. 99% of the sample is jointly covered by OpenAlex, Scilit and WoS. The study suggests that research on retracted literature would require querying more than one source and that it should be advisable to accurately identify and label this literature in academic databases.
Formation and Physical Properties of (NbTa)$$_{67}$$(HfZr)$$_{33}$$ Medium-Entropy Alloy and (NbTa)$$_{67}$$(HfZrTi)$$_{33}$$ High-Entropy Alloy Prepared by Mechanical Alloying
Authors: Idczak Rafał , Sobota Piotr , Gnida Daniel , Kołodziej Sławomir , Chrząszcz Beata , Pasturel Mathieu , Pikul Adam 
Published: June 2024

AbstractThe medium-entropy alloy (NbTa)$$_{0.67}$$

0.67

(HfZr)$$_{0.33}$$

0.33

and the high-entropy alloy (NbTa)$$_{0.67}$$

0.67

(HfZrTi)$$_{0.33}$$

0.33

were prepared by mechanical alloying using high-energy planetary ball mill. The results of X-ray diffraction, scanning electron microscopy, and positron annihilation lifetime spectroscopy measurements suggest that both as-prepared powders are multicomponent alloys in amorphous (or highly disordered) state. The magnetic and thermodynamic results obtained for these powders undoubtedly prove that bulk superconductivity is not observed at temperatures exceeding 2 K. Thermal treatment of both studied materials leads to decomposition of the amorphous phase and precipitation of several crystalline phases. In both annealed samples, the structure of the main crystalline phase was identified as body-centered cubic (bcc), and in this phase, bulk superconductivity was observed below 6.5 K.
Frozen cheese curd as an intermediate for cheese making – homogenization as a tool to regain techno-functional properties
Authors: Schmidt Florian , Hinrichs Jörg 
Published: June 2024

AbstractThis study investigated the effect of milk homogenization/fat globule size on the plasticization of fresh and frozen stored cheese curd and its respective oiling-off behavior. The cheese was frozen either slowly in a freezing chamber or quickly with liquid nitrogen to study the influence of freezing, frozen storage, and thawing. For non-frozen cheese curd, a one-stage homogenization at 2 MPa before renneting still leads to plasticization, while relative oiling off is reduced from 2.6 to 1.9%. This was explained by reduced fat globule size and an increased surface area covered by whey proteins and casein, which is denser and more stable than the native fat globule membrane. For homogenization pressures above 4 MPa, no plasticization was observed. However, freezing and thawing counteract mild homogenization, so minor oiling off occurs, and flowability is enhanced. Extending frozen storage time up to 3 months did not result in more oiling off or higher tan δ values. Moreover, there was no significant effect between the two freezing methods. In conclusion, freezing and frozen storage for up to 3 months is a valid method to preserve cheese curd as techno-functional properties are regained after thawing.
Archaeology meets environmental genomics: implementing sedaDNA in the study of the human past
Authors: Özdoğan Kadir Toykan , Gelabert Pere , Hammers Neeke , Altınışık N. Ezgi , de Groot Arjen , Plets Gertjan 
Published: June 2024

AbstractSedimentary ancient DNA (sedaDNA) has become one of the standard applications in the field of paleogenomics in recent years. It has been used for paleoenvironmental reconstructions, detecting the presence of prehistoric species in the absence of macro remains and even investigating the evolutionary history of a few species. However, its application in archaeology has been limited and primarily focused on humans. This article argues that sedaDNA holds significant potential in addressing key archaeological questions concerning the origins, lifestyles, and environments of past human populations. Our aim is to facilitate the integration of sedaDNA into the standard workflows in archaeology as a transformative tool, thereby unleashing its full potential for studying the human past. Ultimately, we not only underscore the challenges inherent in the sedaDNA field but also provide a research agenda for essential enhancements needed for implementing sedaDNA into the archaeological workflow.
Die transkutane elektrische Nervenstimulation (TENS) – eine effektive und effiziente physikalisch-medizinische Methode
Authors: Crevenna Richard 
Published: June 2024

Zusammenfassung
Die transkutane elektrische Nervenstimulation (TENS) ist eine nichtmedikamentöse, nichtinvasive, etablierte und anerkannte, analgesierende Behandlungsmethode, die stationär, ambulant oder als Heimtherapie angeboten werden kann. TENS ist als Elektrotherapie eine physikalisch-medizinische Therapie und zählt zur Niederfrequenztherapie. Zumeist werden kleine tragbare Geräte für die Heimtherapie verwendet, wobei elektrische Energie an das periphere Nervensystem über Elektroden durch einen externen Stimulator übertragen wird. Der Einsatz der TENS-Therapie ist sehr weit verbreitet, sicher, günstig und effektiv, d. h. effizient. Die Applikation von TENS erfolgt entweder mit niedrigerer Frequenz (etwa 2–4 Hz, als sog. Low-frequency-TENS) oder höherer Frequenz (etwa 70–100 Hz, als sog. High-frequency-TENS). Typische TENS-Indikationen stellen Schmerzsyndrome am Bewegungs- und Stützapparat wie Tendomyopathien (wie z. B. Tennisarm, Golfer-Ellbogen, Achillodynie, Fersensporn), Arthrosen und degenerative Wirbelsäulensyndrome, Kiefergelenkdysfunktionen, Stumpf- und Phantomschmerzen, postoperative Schmerzen sowie gynäkologische Schmerzsyndrome wie u. a. „pelvic pain“ dar. TENS ist auch in der Spätschwangerschaft sicher und effektiv anwendbar. Die Anwendung bei Neuralgien, Radikulopathien (z. B. nach Bandscheibenvorfall), Mononeuropathien (z. B. Karpaltunnelsyndrom) sowie Polyneuropathien ist eine interessante, nichtmedikamentöse Möglichkeit. TENS-Geräte zur analgesierenden TENS-Heimtherapie können bei Verwendung einer entsprechenden Spezialsonde, die typischerweise im linken Ohr appliziert wird, auch zur Durchführung einer sog. „transdermalen aurikulären Vagusstimulation“ verwendet werden.