bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of genetic variation to transgenerational inheritance of DNA methylation
Authors: McRae Allan F , Powell Joseph E , Henders Anjali K , Bowdler Lisa , Hemani Gibran , Shah Sonia , Painter Jodie N , Martin Nicholas G , Visscher Peter M , Montgomery Grant W 
Published: May 2014

Abstract
Background
Despite the important role DNA methylation plays in transcriptional regulation, the transgenerational inheritance of DNA methylation is not well understood. The genetic heritability of DNA methylation has been estimated using twin pairs, although concern has been expressed whether the underlying assumption of equal common environmental effects are applicable due to intrauterine differences between monozygotic and dizygotic twins. We estimate the heritability of DNA methylation on peripheral blood leukocytes using Illumina HumanMethylation450 array using a family based sample of 614 people from 117 families, allowing comparison both within and across generations.

Results
The correlations from the various available relative pairs indicate that on average the similarity in DNA methylation between relatives is predominantly due to genetic effects with any common environmental or zygotic effects being limited. The average heritability of DNA methylation measured at probes with no known SNPs is estimated as 0.187. The ten most heritable methylation probes were investigated with a genome-wide association study, all showing highly statistically significant cis mQTLs. Further investigation of one of these cis mQTL, found in the MHC region of chromosome 6, showed the most significantly associated SNP was also associated with over 200 other DNA methylation probes in this region and the gene expression level of 9 genes.

Conclusions
The majority of transgenerational similarity in DNA methylation is attributable to genetic effects, and approximately 20% of individual differences in DNA methylation in the population are caused by DNA sequence variation that is not located within CpG sites.
Returning individual research results for genome sequences of pancreatic cancer
Authors: Johns Amber L , Miller David K , Simpson Skye H , Gill Anthony J , Kassahn Karin S , Humphris Jeremy L , Samra Jaswinder S , Tucker Katherine , Andrews Lesley , Chang David K , Waddell Nicola , Pajic Marina ,   Australian Pancreatic Cancer Genome Initiative, Pearson John V , Grimmond Sean M , Biankin Andrew V , Zeps Nikolajs 
Published: May 2014

Abstract
Background
Disclosure of individual results to participants in genomic research is a complex and contentious issue. There are many existing commentaries and opinion pieces on the topic, but little empirical data concerning actual cases describing how individual results have been returned. Thus, the real life risks and benefits of disclosing individual research results to participants are rarely if ever presented as part of this debate.

Methods
The Australian Pancreatic Cancer Genome Initiative (APGI) is an Australian contribution to the International Cancer Genome Consortium (ICGC), that involves prospective sequencing of tumor and normal genomes of study participants with pancreatic cancer in Australia. We present three examples that illustrate different facets of how research results may arise, and how they may be returned to individuals within an ethically defensible and clinically practical framework. This framework includes the necessary elements identified by others including consent, determination of the significance of results and which to return, delineation of the responsibility for communication and the clinical pathway for managing the consequences of returning results.

Results
Of 285 recruited patients, we returned results to a total of 25 with no adverse events to date. These included four that were classified as medically actionable, nine as clinically significant and eight that were returned at the request of the treating clinician. Case studies presented depict instances where research results impacted on cancer susceptibility, current treatment and diagnosis, and illustrate key practical challenges of developing an effective framework.

Conclusions
We suggest that return of individual results is both feasible and ethically defensible but only within the context of a robust framework that involves a close relationship between researchers and clinicians.
Genetic and physiological analysis of tolerance to acute iron toxicity in rice
Authors: Wu Lin-Bo , Shhadi Mohamad Yusser , Gregorio Glenn , Matthus Elsa , Becker Mathias , Frei Michael 
Published: May 2014

Abstract

Background
Fe toxicity occurs in lowland rice production due to excess ferrous iron (Fe2+) formation in reduced soils. To contribute to the breeding for tolerance to Fe toxicity in rice, we determined quantitative trait loci (QTL) by screening two different bi-parental mapping populations under iron pulse stresses (1,000 mg L−1 = 17.9 mM Fe2+ for 5 days) in hydroponic solution, followed by experiments with selected lines to determine whether QTLs were associated with iron exclusion (i.e. root based mechanisms), or iron inclusion (i.e. shoot-based mechanisms).

Results
In an IR29/Pokkali F8 recombinant inbred population, 7 QTLs were detected for leaf bronzing score on chromosome 1, 2, 4, 7 and 12, respectively, individually explaining 9.2-18.7% of the phenotypic variation. Two tolerant recombinant inbred lines carrying putative QTLs were selected for further experiments. Based on Fe uptake into the shoot, the dominant tolerance mechanism of the tolerant line FL510 was determined to be exclusion with its root architecture being conducive to air transport and thus the ability to oxidize Fe2+ in rhizosphere. In line FL483, the iron tolerance was related mainly to shoot-based mechanisms (tolerant inclusion mechanism). In a Nipponbare/Kasalath/Nipponbare backcross inbred population, 3 QTLs were mapped on chromosomes 1, 3 and 8, respectively. These QTLs explained 11.6-18.6% of the total phenotypic variation. The effect of QTLs on chromosome 1 and 3 were confirmed by using chromosome segment substitution lines (SL), carrying Kasalath introgressions in the genetic background on Nipponbare. The Fe uptake in shoots of substitution lines suggests that the effect of the QTL on chromosome 1 was associated with shoot tolerance while the QTL on chromosome 3 was associated with iron exclusion.

Conclusion
Tolerance of certain genotypes were classified into shoot- and root- based mechanisms. Comparing our findings with previously reported QTLs for iron toxicity tolerance, we identified co-localization for some QTLs in both pluse and chronic stresses, especially on chromosome 1.
Review of Antonis Liakos's Αποκάλυψη, Ουτοπία και Ιστορία: Οι μεταμορφώσεις της ιστορικής συνείδησης [Apocalypse, utopia and history: the transformations of historical consciousness]
Authors: Stavrakakis Yannis 
Published: May 2014

Review of: Antonis Liakos, Αποκάλυψη, Ουτοπία και Ιστορία: Οι μεταμορφώσεις της ιστορικής συνείδησης [Apocalypse, utopia and history: the transformations of historical consciousness], Athens: Polis, 2011. 478 pp.
Privileged Mexican migrants in Europe: Distinctions and cosmopolitanism on social networking sites
Authors: Nessi Lorena , Bailey Olga Guedes 
Published: May 2014

Abstract
This article examines the ways in which classed distinctions are related to the construction of increasingly cosmopolitan identities on Social Networking Sites (SNSs) amongst Mexican migrants from relatively privileged backgrounds living in Europe. It centres on how user demographics shape many of the concerns and outcomes pertaining to the use of SNSs. It considers the implications of the fact that SNSs are predominantly used by a demographic considered as non-marginalized, mobile and as possessing relatively privileged economic, cultural and social backgrounds. It analyses the ways in which online identities are constructed on SNS profiles using multimedia content to represent specific lifestyles and cultural practices that are used to make distinctions amongst participants, and are related to social, cultural and economic capital. A critical analysis is presented as to how users represent cosmopolitan identities online through the display of tastes and lifestyles in SNS content and into how these representations relate to users’ privileged positions in Mexican society. Bourdieu’s concept of distinction is used to emphasize the utility of considering different forms of capital in analysing the use of SNSs and profile content generated by a specific demographic. This article demonstrates how the analysis of SNS use may contribute towards an understanding of how classed distinctions are made based on this use and of how users negotiate the posting of profile content according to these distinctions and manage (select, edit and share) their representations.
Ethnicity in digital crossroads. Understanding processes of cultural thickening in a mediatized world
Authors: Bozdag Cigdem 
Published: May 2014

Abstract
This article discusses existing approaches to ethnic community building in diaspora and suggests that the concept of ‘cultural thickening’ can be useful for the understanding of ethnicity in a ‘mediatized world’. It is argued that in everyday life, ethnicity is continuously being (re-)constructed through repetitive practices of mediated and non-mediated communication, through which ethnic boundary-making takes place. This theoretical framework is then discussed through the cases of four diasporic websites of the Moroccan and Turkish diaspora that are analysed through media ethnography. It is argued, firstly, that communication spaces for negotiations about ethnicity are expanded by these websites. Through debates on ‘banal’ practices of everyday life relating to different fields such as cooking, sports or education among others, the users of the websites discuss who belongs to their community and what it means to belong to the community. Second, using these diasporic websites becomes a shared characteristic of the ethnic community in the eyes of the members of diasporas.
Diasporas and new media: Connections, identities, politics and affect
Authors: Siapera Eugenia 
Published: May 2014

Abstract
Diasporas in the New Media Age: Identity, Politics and Community, A. Alonso and A. Oiarzabal (eds) (2010) Reno: University of Nevada Press, pp. 288, ISBN 10: 0874178150 (pbk), €36.28
Digital Diasporas: Identity and Transnational Engagement, J. Brinkerhoff (2009) Cambridge: Cambridge University Press, pp. 288, ISBN 10: 0521741432 (pbk), €22.30
Migration and New Media: Transnational Families and Polymedia, M. Madianou and D. Miller (2012) London: Routledge, pp. 192, ISBN 10: 041567929X (pbk), €26.52
Diaspora Online: Identity Politics and Romanian Migrants, R. Trandafoiu (2013) Oxford: Berghahn, pp. 212, ISBN 10: 0857459430 (hbk), €47.93
Forced migrants, emotive practice and digital heterotopia
Authors: Witteborn Saskia 
Published: May 2014

Abstract
Despite being caught in cycles of waiting and being arrested in institutionalized accommodations, forced migrants engage increasingly in digital border crossings. While the study of digital practice has attracted much scholarly interest, the role of emotions in processes of migration and digital connecting has been neglected. This article explores the role of emotions in the structuring of and engagement with digital heterotopias. Field research with 127 forced migrants in Germany over a period of three years illustrates how shame and fear structure digital practice and heterotopic space and regulate digital connectivity. The study suggests that emotions are instrumental in gendering digital practice and influencing solidarization processes, with shame and fear strengthening spaces of exclusion and supporting the logics of control by the nation state.
Sensory Friendly Concerts: A community music therapy initiative to promote Neurodiversity
Authors: Shiloh C. J. , LaGasse A. Blythe 
Published: May 2014

Abstract
Community is essential for individuals to feel like a part of something larger; however, many individuals with disabilities and their families lack a connection to community due to the display of unusual social behaviours or unavailable accommodations when at community-based events. Community music therapy (CoMT) encompasses an effort to build community around music-making and enjoyment for the collective whole, as well as supporting social justice and self-advocacy for individuals. One CoMT effort specific to individuals on the autism spectrum is the Sensory Friendly Concerts® (SFCs), a music enjoyment and making venue that promotes the social acceptance of each individual, specifically of those who identify as ‘autistic’ and seek to develop an autistic culture and community. SFCs are not only a venue to create ‘equal access to the fine arts’, but also serves as a platform for self-advocacy, thus promoting the social justice of a typically marginalized population. The purpose of this project report is to discuss how SFCs, as a CoMT initiative, can provide an opportunity for individuals and families to explore the arts, develop an inclusive community and promote social justice for autistic people. To this effect, this article will discuss SFCs within the broader scope of community music and CoMT, introduce core concepts of the Neurodiversity movement, and present initial programme evaluation data and personal accounts from SFCs.
Revisiting ‘Community music therapy and the winds of change’ (2002): An original article and a retrospective evaluation
Authors: Ansdell Gary 
Published: May 2014

Abstract
This article contains my article ‘Community music therapy and the winds of change’, which was written twelve years ago. It also contains my reflection on this article. In this I explore some of the circumstances in the United Kingdom that prompted writing the original article, and consider these in relation to subsequent developments of community music therapy (CoMT) as an international movement. I also evaluate what I think I got wrong and right in the original article, and what I could not have anticipated in 2002. I finish by suggesting that CoMT has functioned as a ‘trojan paradigm’: smuggling into an increasingly reductionist, individualized and medicalized culture of treatment and care a more flexible ecological understanding of the complex relationships between music, people, health, illness and well-being.
Health musicking in Skiffle Steel Orchestra: Thoughts on collaboration between community music therapy and medical ethnomusicology
Authors: Jones Jeffrey A. 
Published: May 2014

Abstract
This article presents a study of music and health promotion in Skiffle Steel Orchestra, a community music group located in San Fernando, Trinidad. It is based on ethnomusicological fieldwork data collected through an ongoing research partnership with Skiffle that began in 2005 and continues through the present. The study features health musicking that facilitates the embodiment of cultural values that engender a way of life, an outlook through which members of Skiffle ascribe meaning to their experiences that potentially encourages health promoting attitudes and behaviours as well as states of well-being. The primary objective for the article is to document and analyse this phenomenon, detailing the specific context as well as the general principles that underlie it, thus contributing to the body of literature about the potential for health promotion through musical means. A secondary objective of the article is to take advantage of, and encourage further, the potential for multidisciplinary and collaborative study of music and health promotion made possible by some of the theoretical perspectives and methodological procedures common to both community music therapy (CoMT) and medical ethnomusicology.
Community music therapy and the process of learning about and struggling for openness
Authors: Stige Brynjulf 
Published: May 2014

Abstract
In this article I attempt to understand bits of the ongoing change that the emerging movement of community music therapy (CoMT) reflects and instigates, through an exploration of processes of learning about and struggling for openness. I argue that change involves painful unlearning and challenging relearning and I examine this claim through discussion of three moments of change in my own relationship to CoMT. I focus on three moments that happened to emerge with a ten years distance (in 1983, 1993 and 2003). The first moment I call ‘Towards an open door’ and it reflects unlearning and relearning in relation to a more contextual and ecological practice of music therapy. The second moment I call ‘Towards a more open discourse’ and it reflects the unlearning and relearning necessary for a more grounded yet interdisciplinary discourse of music therapy. The third moment I call ‘Towards an open floor’ and it reflects the need for an ongoing, international, and critical debate on the assumptions, values, and priorities that characterize contemporary music therapy. Through reflections on these three moments, I try to depict interrelationships of theory and practice as well as interrelationships of music therapy and broader sociocultural–political forces. I particularly focus on how CoMT has created new possibilities for music therapy to dialogue and debate with the medical discourses that dominate contemporary health care services in most societies.
Examination of roles, tasks and management competencies of moderators through a kaizen analysis
Authors: Takács T. , Matkó A. 
Published: May 2014

Abstract
This study presents the examination of the leadership in a multi-national company in Debrecen, in which we examine the relationship between lean and leadership. We identified the competitiveness within a kaizen implementation of the company's moderators with the help of a questionnaire. With help of the identified management competencies we determine the leadership style, which is necessary for the operation of a successful and effective lean management.
Structural performance of steel fibre reinforced concrete — Part II. Compressive behaviour and stress-strain relationship
Authors: Kovács I. 
Published: May 2014

Abstract
The present paper of a series deals with the experimental characterisation of compressive strength and compressive behaviour (stress-strain relationship) of different structural concrete containing different volume of steel fibre reinforcement (0 V%, 0.5V%, 1.0V%, 75 kg/m3, 150 kg/m3) and different configuration of steel fibres (crimped, hooked-end). Compressive tests were carried out on standard cube (150 mm × 150 mm × 150 mm) and cylinder (Ø = 150 mm, l = 300 mm) specimens considering random fibre orientation. Since the fibre orientation may significantly affect the compressive behaviour, test series were also performed on cylinders (Ø = 70 mm, l = 100 mm) drilled out of fibre reinforced concrete beams and prisms (100 mm × 100 mm × 240 mm) sawn out of steel fibre reinforced deep beams. Throughout the tests stress-strain relationships were registered on the standard cube and cylinder specimens as well. In conclusion, behaviour of steel fibre reinforced concrete was examined in compression taking into consideration different experimental parameters such as fibre content, type of fibres, fibre configuration, fibre orientation, size of specimens (size effect) and concrete mixture.
General incentives for renewable energy investment and energy efficiency measures in Hungary
Authors: Kiss J. T. , Kocsis I. 
Published: May 2014

Abstract
In this paper we analyse the trends and developments of energy imports as a percentage of gross inland energy consumption including bunkers in Hungary and the European Union countries between 2000 and 2011. Data show that the average of the energy dependence increased in the EU27 Member States (7.1 percentage points) and in Hungary, too (3.4 percentage points). The energy intensity in Member States is examined as well. According to the data the energy intensity decreased in the majority of the Member States, the average decreased by 16 percent.
A review on opportunities for the development of heat pump drying systems in South Africa
Authors: Kivevele Thomas , Huan Zhongjie 
Published: May 2014

Recently, it has been discovered that heat pump drying is an efficient method of drying for drying industries. Heat pumps deliver more heat during the drying process than the work input to the compressor. Heat pump drying is a more advanced method than the traditional South African industrial and agricultural drying methods, such as direct/indirect sunlight, wood burning, fossil fuel burning, electrical heating and diesel engine heating. Heat pump dryers provide high energy efficiency with controllable temperature, air flow and air humidity and have significant energy-saving potential. In the last decade the market for heat pump systems for water heating and space cooling/heating has grown in South Africa, but the development of heat pumps for industrial and agricultural drying is very slow. As a result of high increases in fossil fuel prices and electricity in South Africa, as well as the problem of CO2 emissions, green energy, energy saving and energy efficiency are imperative. The development of heat pump drying systems in South Africa is an efficient way to solve energy problems in drying applications as this technology is still in its infancy. We review studies on heat pump drying and compare the methods therein with the most common methods of drying in South Africa.
The Discovery of Natural Miscanthus Accessions Related to Miscanthus × giganteus Using Chloroplast DNA
Authors: Feng X.P. , Lourgant K. , Castric V. , Saumitou‐Laprade P. , Zheng B.S. , Jiang D. , Brancourt‐Hulmel M. 
Published: May 2014

ABSTRACTIt is essential to enlarge the pool of varieties of the biomass crop Miscanthus to support the increase in its cultivation area, and several natural species from eastern or southeastern Asia could be of interest. Our main study objectives were: (i) to investigate the frequency spectrum of the haplotypes of natural Chinese accessions and their geographic distribution in China, and (ii) to identify the Chinese chloroplast genomes related to the maternal genomes of cultivated European varieties. We studied 21 clones cultivated in Europe and 44 wild Chinese accessions from 10 Chinese provinces covering four species of Miscanthus: M. sacchariflorus (Maxim.) Hack., M. sinensis Andersson, M. floridulus (Labill.) Warb. ex K. Schum. & Lauterb., and M. × giganteus J.M. Greef & Deuter ex Hodkinson & Renvoize. We used chloroplast DNA from sugarcane (Saccharum officinarum L.) due to its taxonomic relationship with Miscanthus and designed primers using the large single‐copy region of the chloroplast genome. The polymorphisms belonged to noncoding and coding regions and were substitutions that corresponded to single nucleotide polymorphisms. Haplotypes were then determined, enabling the investigation of the haplotype frequency spectrum and the geographic distribution of the accessions in China. Furthermore, the maternal genome of M. × giganteus appears related to some Chinese M. sacchariflorus clones. The corresponding geographic native area of these wild clones could be of interest to enlarge the genetic variability for the breeding of new interspecific hybrids.