bluuebunny/crossref_metadata_2025_split huggingface dataset:
Electro‐Ionic‐Field Regulation through Dipole Molecule Layer toward Dendrite‐Free Zinc Anode
Authors: Cai Shan , Hu Jiugang , Wu Riyan , Luo Yuqing , Xin Yuntao , Zou Guoqiang , Hou Hongshuai , Ji Xiaobo 
Published: July 2024

AbstractZinc metal is a high‐capacity and cost‐effective anode material for aqueous zinc‐ion batteries, but its development is impeded by dendrite growth and interfacial side reactions. In this study, a unique dipole molecule (DPM) layer is constructed on a zinc surface via an in situ etching‐growth strategy to regulate the surface electric field and ion distribution. Theoretical calculations and experiments confirm that the asymmetrical charge distribution within the DPM layer can significantly remodel the electric field of the Zn anode surface. The zincophilic DPM layer accelerates the migration of zinc ions through ordered ion channels. Electro‐ionic field regulation via the DPM layer achieves dendrite‐free deposition and reduces the formation of byproducts. The DPM‐Zn symmetrical cells exhibit ultralow voltage hysteresis (≈ 24.2 mV), highly reversible zinc plating/stripping behavior, and stable cycling over 1700 h at 1 mA cm−2. The DPM‐Zn||MnO2 full cells exhibited a higher specific capacity and cycle stability than the bare Zn anode. This work verifies the feasibility of electro‐ionic‐field synergistic regulation for robust Zn anodes and provides new insights into the interface design of metal anodes.
Nanomaterial‐Mediated Delivery of MLKL Plasmids Sensitizes Tumors to Immunotherapy and Reduces Metastases
Authors: Chu Tianjiao , Maksoudian Christy , Pedrotti Stefania , Izci Mukaddes , Perez Gilabert Irati , Koutsoumpou Xanthippi , Sargsian Ara , Girmatsion Hermon , Goncalves Filipa Roque , Scheele Colinda LGJ , Manshian Bella B. , Soenen Stefaan J. 
Published: July 2024

AbstractCancer immunotherapy has emerged as a promising approach for the induction of an antitumor response. While immunotherapy response rates are very high in some cancers, the efficacy against solid tumors remains limited caused by the presence of an immunosuppressive tumor microenvironment. Induction of immunogenic cell death (ICD) in the tumor can be used to boost immunotherapy response in solid cancers by eliciting the release of immune‐stimulatory components. However, the delivery of components inducing ICD to tumor sites remains a challenge. Here, a novel delivery method is described for antitumor therapy based on MLKL (Mixed Lineage Kinase Domain‐Like), a key mediator of necroptosis and inducer of ICD. A novel highly branched poly (β‐amino ester)s (HPAEs) system is designed to efficiently deliver MLKL plasmid DNA to the tumor with consequent enhancement of immune antigen presentation for T cell responses in vitro, and improved antitumor response and prolonged survival in tumor‐bearing mice. Combination of the therapy with anti‐PD‐1 treatment revealed significant changes in the composition of the tumor microenvironment, including increased infiltration of CD8+ T cells and tumor‐associated lymphocytes. Overall, the HPAEs delivery system can enhance MLKL‐based cancer immunotherapy and promote antitumor immune responses, providing a potential treatment to boost cancer immunotherapies.
Dual‐Barb Microneedle with JAK/STAT Inhibitor‐Loaded Nanovesicles Encapsulation for Tendinopathy
Authors: Chen Minhao , Zou Fengkai , Wang Pei , Hu Wenbo , Shen Peng , Wu Xinyuan , Xu Hua , Rui Yunfeng , Wang Xiansong , Wang Youhua 
Published: July 2024

AbstractTendon stem/progenitor cells (TSPCs) are crucial for tendon repair, regeneration, and homeostasis. Dysfunction of TSPCs, due to aberrant activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway, contributes to tendinopathy. Unfortunately, the effectiveness of conventional subcutaneous injection targeting at suppressing JAK/STAT signaling pathway is limited due to the passive diffusion of drugs away from the injury site. Herein, a novel poly‐gamma‐glutamic acid (γ‐PGA) dual‐barb microneedle (MN) path loaded with TSPCs‐derived nanovesicles (NVs) containing JAK/STAT inhibitor WP1066 (MN‐WP1066‐NVs) for tendinopathy treatment is designed. The dual‐barb design of the MN ensures firm adhesion to the skin, allowing for sustained and prolonged release of WP1066‐NVs, facilitating enhanced TSPCs self‐renewal, migration, and stemness in tendinopathy. In vitro and in vivo experiments demonstrate that the degradation of γ‐PGA patch tips facilitates the gradual release of WP1066‐NVs at the lesion site. This release alleviates inflammation, suppresses extracellular matrix degradation, and restores normal tendon histological structure by inhibiting the JAK/STAT pathway. These findings suggest that the multifunctional dual‐barb MN patch offers a novel and effective therapeutic strategy for tendinopathy treatment.
Pseudo‐Jahn–Teller Effect Breaks the pH Dependence in Two‐Electron Oxygen Electroreduction
Authors: Xia Baokai , Du Jiale , Li Ming , Duan Jingjing , Chen Sheng 
Published: July 2024

AbstractThe hydrogenation of small molecules (like O2 and CO2) often exhibits strong activity dependence on pHs because of discrepant proton donor environments. However, some catalysts can show seldom dependence on two‐electron oxygen electroreduction, a sustainable route of O2 hydrogenation to hydrogen peroxide (H2O2). In this work, a pH‐resistant oxygen electroreduction system arising from the pseudo‐Jahn–Teller effect is demonstrated. Thorough operando Raman spectra, local environment analyses and density function theory simulations, the lattice distortion of TiOxFy that introduces the pseudo‐Jahn–Teller effect contributing to regulating local pHs at electrode–electrolyte interfaces and the absorption/desorption of key *OOH intermediate is revealed. Consequently, as comparison to 78.6% activity attenuation for common catalyst, the TiOxFy displays minor activity decay (3.2%) in the pH range of 1–13 with remarkable Faradaic efficiencies (93.4–96.4%) and H2O2 yield rates (595–614 mg cm−2 h−1) in the current densities of 100–1000 mA cm−2. Further techno‐economics analyses display the H2O2 production cost dependent on pHs, giving the lowest H2O2 price of $0.37 kg−1. The present finding is expected to provide an additional dimension to pseudo‐Jahn–Teller effect that leverages systems beyond traditional conception.
Suppressed Defects by Functional Thermally Cross‐Linked Fullerene for High‐Efficiency Tin‐Lead Perovskite Solar Cells
Authors: Zhao Jinbo , Su Zhenhuang , Pascual Jorge , Wu Hongzhuo , Wang Haibin , Aldamasy Mahmoud H. , Zhou Zhengji , Wang Chenyue , Li Guixiang , Li Zhe , Gao Xingyu , Hsu Chain‐Shu , Li Meng 
Published: July 2024

AbstractMixed tin‐lead (Sn‐Pb) perovskites have attracted the attention of the community due to their narrow bandgap, ideal for photovoltaic applications, especially tandem solar cells. However, the oxidation and rapid crystallization of Sn2+ and the interfacial traps hinder their development. Here, cross‐linkable [6,6]‐phenyl‐C61‐butyric styryl dendron ester (C‐PCBSD) is introduced during the quenching step of perovskite thin film processing to suppress the generation of surface defects at the electron transport layer interface and improve the bulk crystallinity. The C‐PCBSD has strong coordination ability with Sn2+ and Pb2+ perovskite precursors, which retards the crystallization process, suppresses the oxidation of Sn2+, and improves the perovskite bulk and surface crystallinity, yielding films with reduced nonradiative recombination and enhanced interface charge extraction. Besides, the C‐PCBSD network deposited on the perovskite surface displays superior hydrophobicity and oxygen resistance. Consequently, the devices with C‐PCBSD obtain PCEs of up to 23.4% and retained 97% of initial efficiency after 2000 h of storage in a N2 atmosphere.
Retinomorphic Color Perception Based on Opponent Process Enabled by Perovskite Bipolar Photodetectors
Authors: Ng Si En , Yantara Natalia , Tu Ngo Anh , Erdenebileg Enkhtur , Li Patrick Wen Feng , Sharma Divyam , Lam Yeng Ming , Mhaisalkar Subodh , Basu Arindam , Chattopadhyay Anupam , Mathews Nripan 
Published: July 2024

AbstractThe ability to perceive color by the retina can be attributed to both its trichromatic photoreceptors and the antagonistic neural wiring known as the opponent process. While neuromorphic sensors have been shown to demonstrate memory and adaptation capabilities, color perception is still challenging due to the intrinsic lack of spectral selectivity in narrow bandgap semiconductors. Furthermore, research on emulating neural wiring is severely lacking. The combination of halide perovskite materials with a tunable bandgap and a novel bipolar photodetector design emulates the efficiency of the retina in processing color information. The stimuli‐responsive material is also responsible for maintaining partial color constancy—an adaptation feature. Leveraging the unique enhancement of color contrasts, an in‐sensor data compression and edge detection can also be demonstrated. The color perception, chromatic adaptation, and color contrast enhancement make perovskite bipolar photodetectors a unique example where the sensor and neural wiring can be co‐developed in conjunction.
Achieving High‐Capacity Cathode Presodiation Agent Via Triggering Anionic Oxidation Activity in Sodium Oxide
Authors: Chen Yilong , Zhu Yuanlong , Sun Zhefei , Kuai Xiaoxiao , Chen Jianken , Zhang Baodan , Yin Jianhua , Luo Haiyan , Tang Yonglin , Zeng Guifan , Zhang Kang , Li Li , Xu Juping , Yin Wen , Qiu Yongfu , Zou Yeguo , Ning Ziyang , Ouyang Chuying , Zhang Qiaobao , Qiao Yu , Sun Shi‐Gang 
Published: July 2024

AbstractCompensating for the irreversible loss of limited active sodium (Na) is crucial for enhancing the energy density of practical sodium‐ion batteries (SIBs) full‐cell, especially when employing hard carbon anode with initially lower coulombic efficiency. Introducing sacrificial cathode presodiation agents, particularly those that own potential anionic oxidation activity with a high theoretical capacity, can provide additional sodium sources for compensating Na loss. Herein, Ni atoms are precisely implanted at the Na sites within Na2O framework, obtaining a (Na0.89Ni0.05□0.06)2O (Ni–Na2O) presodiation agent. The synergistic interaction between Na vacancies and Ni catalyst effectively tunes the band structure, forming moderate Ni–O covalent bonds, activating the oxidation activity of oxygen anion, reducing the decomposition overpotential to 2.8 V (vs Na/Na+), and achieving a high presodiation capacity of 710 mAh/g≈Na2O (Na2O decomposition rate >80%). Incorporating currently‐modified presodiation agent with Na3V2(PO4)3 and Na2/3Ni2/3Mn1/3O2 cathodes, the energy density of corresponding Na‐ion full‐cells presents an essential improvement of 23.9% and 19.3%, respectively. Further, not limited to Ni–Na2O, the structure–function relationship between the anionic oxidation mechanism and electrode–electrolyte interface fabrication is revealed as a paradigm for the development of sacrificial cathode presodiation agent.
A Coplanar Edible Rechargeable Battery with Enhanced Capacity
Authors: Galli Valerio , Annese Valerio F. , Coco Giulia , Cataldi Pietro , Scribano Vincenzo , Ilic Ivan K. , Athanassiou Athanassia , Caironi Mario 
Published: July 2024

AbstractEdible rechargeable batteries represent a novel opportunity for energy storage, which currently involves the use of toxic materials. Being entirely made of food‐derived materials and additives, such batteries open the way to electronic systems characterized by unprecedented features. Their sustainability and safety can be crucial for replacing traditional batteries in low‐power applications, like agrifood and medicine, reducing environmental impact and health hazards. Yet, limitations in capacity and architecture, and concerns about stability at elevated temperature, humidity, and prolonged storage time, severely limit their current application potential. Here, a new coplanar architecture of a riboflavin‐quercetin edible battery with increased capacity, reaching 20 µAh, and operational stability of two weeks is presented. The battery is tested in diverse environmental conditions to assess its possible implementation in different scenarios, showing stable performance between 0 and 37 °C. As a proof‐of‐concept application, the coplanar architecture is exploited to develop a 3‐cell battery with a voltage of ≈2 V and demonstrate the possibility of powering a commercial Internet of Things (IoT) module. The new design and data herein presented represent significant steps toward widening the opportunities offered by edible batteries and their implementation in low‐power electronics.
Facile Wet‐Process to Free‐Standing Whispering Gallery Mode Resonators Mixed with Spherical Silica Gel and π‐Conjugated Molecules
Authors: Matsuo Takumi , Tanikubo Hiroki , Hayashi Shotaro 
Published: July 2024

AbstractWhispering‐gallery‐mode (WGM) resonators composed of organic and/or inorganic materials have been used in highly sensitive sensors, logic gates, and miniaturized lasers because of the total internal reflection of photons. However, most fabrication methods have been limited to bottom‐up self‐assembly; whereas, a facile top‐down process is preferable. Here, a wet‐process fabrication of WGM resonators mixed with 5 µm‐diameter spherical silica‐gels and various π‐conjugated compounds is demonstrated. The materials are fabricated by dip‐coating photoluminescent molecules onto submicron‐scale silica‐gel spheres. The shapes and large specific surface areas of templates are maintained before and after coating, and the coated molecules are uniformly distributed. The hybrid spheres provided WGM photoluminescence spectra based on the total internal reflection of photoluminescence in the sphere. The hybrid spheres are applicable as WGM sensors because of their large specific surface area (>4 × 102 m2 g−1). In particular, gas sensing of toluene, which has been used as a standard for environmental contamination, and found that the WGM photoluminescence peaks are shifted by 5 nm is demonstrated. The detection resolution is calculated to be several hundred ppm level. The hybrid spheres can be placed or transferred onto various surfaces without micromanipulation, which suggested a wide range of possible applications.
Advancements in APOE and dementia research: Highlights from the 2023 AAIC Advancements: APOE conference
Authors: Kloske Courtney M. , Belloy Michael E. , Blue Elizabeth E. , Bowman Gregory R. , Carrillo Maria C. , Chen Xiaoying , Chiba‐Falek Ornit , Davis Albert A. , Paolo Gilbert Di , Garretti Francesca , Gate David , Golden Lesley R. , Heinecke Jay W. , Herz Joachim , Huang Yadong , Iadecola Costantino , Johnson Lance A. , Kanekiyo Takahisa , Karch Celeste M. , Khvorova Anastasia , Koppes‐den Hertog Sascha J. , Lamb Bruce T. , Lawler Paige E. , Guen Yann Le , Litvinchuk Alexandra , Liu Chia‐Chen , Mahinrad Simin , Marcora Edoardo , Marino Claudia , Michaelson Danny M. , Miller Justin J. , Morganti Josh M. , Narayan Priyanka S. , Naslavsky Michel S. , Oosthoek Marlies , Ramachandran Kapil V. , Ramakrishnan Abhirami , Raulin Ana‐Caroline , Robert Aiko , Saleh Rasha N. M. , Sexton Claire , Shah Nilomi , Shue Francis , Sible Isabel J. , Soranno Andrea , Strickland Michael R. , TCW Julia , Thierry Manon , Tsai Li‐Huei , Tuckey Ryan A. , Ulrich Jason D. , van der Kant Rik , Wang Na , Wellington Cheryl L. , Weninger Stacie C. , Yassine Hussein N. , Zhao Na , Bu Guojun , Goate Alison M. , Holtzman David M. 
Published: July 2024

AbstractINTRODUCTIONThe apolipoprotein E gene (APOE) is an established central player in the pathogenesis of Alzheimer's disease (AD), with distinct apoE isoforms exerting diverse effects. apoE influences not only amyloid‐beta and tau pathologies but also lipid and energy metabolism, neuroinflammation, cerebral vascular health, and sex‐dependent disease manifestations. Furthermore, ancestral background may significantly impact the link between APOE and AD, underscoring the need for more inclusive research.METHODSIn 2023, the Alzheimer's Association convened multidisciplinary researchers at the “AAIC Advancements: APOE” conference to discuss various topics, including apoE isoforms and their roles in AD pathogenesis, progress in apoE‐targeted therapeutic strategies, updates on disease models and interventions that modulate apoE expression and function.RESULTSThis manuscript presents highlights from the conference and provides an overview of opportunities for further research in the field.DISCUSSIONUnderstanding apoE's multifaceted roles in AD pathogenesis will help develop targeted interventions for AD and advance the field of AD precision medicine.Highlights
APOE is a central player in the pathogenesis of Alzheimer's disease.
APOE exerts a numerous effects throughout the brain on amyloid‐beta, tau, and other pathways.
The AAIC Advancements: APOE conference encouraged discussions and collaborations on understanding the role of APOE.
Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p‐tau217 immunoassays
Authors: Figdore Daniel J. , Griswold Michael , Bornhorst Joshua A. , Graff‐Radford Jonathan , Ramanan Vijay K. , Vemuri Prashanthi , Lowe Val J. , Knopman David S. , Jack Clifford R. , Petersen Ronald C. , Algeciras‐Schimnich Alicia 
Published: July 2024

AbstractINTRODUCTIONWe aimed to evaluate clinical interpretation cutpoints for two plasma phosphorylated tau (p‐tau)217 assays (ALZpath and Lumipulse) as predictors of amyloid status for implementation in clinical practice.METHODSClinical performance of plasma p‐tau217 against amyloid positron emission tomography status was evaluated in participants with mild cognitive impairment or mild dementia (n = 427).RESULTSUsing a one‐cutpoint approach (negative/positive), neither assay achieved ≥ 90% in both sensitivity and specificity. A two‐cutpoint approach yielding 92% sensitivity and 96% specificity provided the desired balance of false positives and false negatives, while categorizing 20% and 39% of results as indeterminate for the Lumipulse and ALZpath assays, respectively.DISCUSSIONThis study provides a systematic framework for selection of assay‐specific cutpoints for clinical use of plasma p‐tau217 for determination of amyloid status. Our findings suggest that a two‐cutpoint approach may have advantages in optimizing diagnostic accuracy while minimizing potential harm from false positive results.Highlights
Phosphorylated tau (p‐tau)217 cutpoints for detection of amyloid pathology were established.
A two‐cutpoint approach exhibited the best performance for clinical laboratory use.
p‐tau217 assays differed in the percentage of results categorized as intermediate.
Low‐Dose Interleukin‐2 Reverses Traumatic Brain Injury‐Induced Cognitive Deficit and Pain in a Murine Model
Authors: Czerpaniak Katherine , do Nascimento Leandro Flores , Guo Tingting , Zhang Jintao , Liu Xuemei , Sarzaeim Mojdeh , Fine Zachary D. , Cao Yu‐Qing 
Published: July 2024

ObjectiveDespite the high prevalence, mild traumatic brain injury (mTBI)‐induced chronic headache and cognitive deficits are poorly understood and lack effective treatments. Low‐dose interleukin‐2 (LD‐IL‐2) treatment soon after mTBI or overexpressing IL‐2 in brain astrocytes prior to injury protects mice from developing post‐traumatic headache (PTH)‐related behaviors and cognitive decline. The present study addresses a clinically relevant knowledge gap: whether LD‐IL‐2 treatment long after the initial injury is still effective for chronic PTH and cognitive deficits.MethodsmTBI was induced by a noninvasive closed‐head weight drop method. LD‐IL‐2 was administered 4–6 weeks post‐mTBI to assess its effects on chronic PTH‐related facial mechanical hypersensitivity as well as mTBI‐induced impairment in novel object recognition and object location tests. Endogenous regulatory T (Treg) cells were depleted to investigate the mechanism of action of LD‐IL‐2.ResultsDelayed LD‐IL‐2 treatment abolished chronic PTH‐related behaviors. It also completely reversed mTBI‐induced cognitive impairment in both male and female mice. Treg cell depletion not only prolonged PTH‐related behaviors but also abolished the effects of LD‐IL‐2. Interestingly, LD‐IL‐2 treatment significantly increased the number of Treg cells in dura but not in brain tissues.InterpretationThese results suggest that the beneficial effects of LD‐IL‐2 treatment are mediated through the expansion of meningeal Treg cells. Collectively, our study identifies Treg as a cellular target and LD‐IL‐2 as a promising therapy for both chronic PTH and mTBI‐induced cognitive impairment for both males and females, with a wide therapeutic time window and the potential of reducing polypharmacy in mTBI treatment. ANN NEUROL 2024;96:508–525
Versatile Dehydration‐Assisted Functionalization of Quantum Dots and Rods
Authors: Chen Chi , Luo Xin , Bathe Mark 
Published: July 2024

AbstractFunctionalization of quantum dots (QDs) and quantum rods (QRs) with ligands is essential for their further practical application across various domains. Dehydration‐assisted functionalization (DAF) is a versatile method applicable to a wide range of hydrophilic ligands with an affinity to the surface of QDs and QRs. This approach facilitates rapid one‐pot ligand exchange and dense modification by efficiently transferring these ligands onto the surface of QDs and QRs. This study demonstrates the efficacy of DAF in preparing chiral QRs, engineering the surface charge of QDs, utilizing QR aggregates, and conjugating dense DNA onto cadmium‐free InP/ZnS QDs. DAF therefore offers a versatile solution for hydrophilic ligand functionalization of QDs and QRs applicable to diverse applications.
Leap‐Type Response of Redox/Photo‐Active Lanthanide‐Based Metal–Organic Frameworks for Early and Accurate Screening of Prostate Cancer
Authors: Ge Kaiming , Chen Guoli , Zhang Dapeng , Hao Ji‐Na , Li Yongsheng 
Published: July 2024

AbstractThe development of high‐accuracy technologies to distinguish the quite tiny concentration change of tumor markers between negative and positive is of vital significance for early screening and diagnosis of cancers, but is still a great challenge for the conventional biosensors because of their “gradual” detection mode. Herein, a unique “leap‐type” responsive lanthanide MOF‐based biosensor (designated as Tb‐CeMOF‐X) with defect‐mediated redox‐/photo‐activities is developed for precisely identifying acid phosphatase (ACP), an early pathological marker of prostate cancer (PCa) in serum. The engineered Tb‐CeMOF‐X probe achieves a bursting switch‐on luminescence at the critical concentration of ACP (9 U ⋅ L−1), while keeping silent below this threshold, undergoing a qualitative signal change from “zero” to “one” between negative and positive indicators and thus significantly improving the identification precision. Significantly, such “leap‐type” response performance can be further edited and amplified by rational defect engineering in the crystal structure to improve the accessibility of active centers, consequently maximizing the detection sensitivity toward ACP in the complex biological media. This study proposes the first paradigm for the development of “leap‐type” biosensors with ultra‐sensitive differentiation capability between negative and positive, and provides a potentially valuable tool for early and accurate screening of PCa.