bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genome‐wide association study of growth traits in Jinghai Yellow chicken hens using SLAF‐seq technology
Authors: Wang W. H. , Wang J. Y. , Zhang T. , Wang Y. , Zhang Y. , Han K. 
Published: September 2015

SummaryIn this study, we performed a new genome‐wide association study using SLAF‐seq technology. A total of 19 single nucleotide polymorphism effects involving nine different SNP markers reached 5% Bonferroni‐corrected genome‐wide significance. In addition, a 5‐Mb region spanning 72.9–77.9 Mb on GGA4, exhibiting many significant SNP effects, was identified. The LDB2 gene in this region had a very strong association with body weight. Another SNP on GGA1, located in the INTS6 gene, had the strongest association with late body weight (weeks 10–16). Some of the SNPs that reached suggestive significance level overlapped with previously reported quantitative trait locus regions.
Improved recombinant Api m 1‐ and Ves v 5‐based IgE testing to dissect bee and yellow jacket allergy and their correlation with the severity of the sting reaction
Authors: Šelb J. , Kogovšek R. , Šilar M. , Košnik M. , Korošec P. 
Published: September 2015

SummaryBackgroundNo study has assessed the diagnostic sensitivity of rApi m 1 and rVes v 5 on Immulite testing system.ObjectiveTo compare the diagnostic sensitivity of commercially available venom recombinant allergens between the currently available immunoassays [ImmunoCAP (CAP) and Immulite (LITE)] and establish their correlation with the severity of the sting reaction.MethodsThis study evaluated 95 bee venom and 110 yellow jacket venom‐allergic subjects. We measured the levels of sIgE to rApi m 1, rVes v 5 (LITE and CAP), rApi m 2 (LITE), rVes v 1 (CAP) and total IgE (CAP). Forty‐nine healthy subjects served as controls.ResultsThe diagnostic sensitivity of rApi m 1 and rVes v 5 was significantly higher with the LITE than with the CAP system (71% vs. 88% and 82% vs. 93%). The specificity of both assays for both allergens was between 94% and 98%. Twenty‐nine patients that tested negative for rApi m 1 or rVes v 5 with CAP were positive with LITE, but none of the patients that tested negative with LITE were positive with CAP. The positive values of rApi m 1 and rVes v 5 were on average 2.7 and 2.3 times higher, with the LITE than with the CAP system. The combination of rApi m 1 and rApi m 2 (LITE) and the combination of rVes v 5 (LITE) and rVes v 1 (CAP) almost matched the sensitivity of native venoms (95% and 97%, respectively), whereas the diagnostic sensitivity of the combination of rVes v 5 and rVes v 1 (CAP) did not reach the sensitivity of rVes v 5 (LITE) alone (90% vs. 93%). IgE levels to venom recombinants and total IgE did not correlate with the severity of sting reaction.Conclusions & Clinical RelevanceThe use of rApi m 1 and rVes v 5 with the LITE system significantly enhanced diagnostic utility of venom recombinants and should improve the dissection of bee and yellow jacket venom allergy.
A cone beam computed tomography (CBCT) study of buccal plate thickness of the maxillary and mandibular posterior dentition
Authors: Temple Kayleigh E. , Schoolfield John , Noujeim Marcel E. , Huynh‐Ba Guy , Lasho David J. , Mealey Brian L. 
Published: September 2015

AbstractBackgroundBuccal plate thickness is of clinical importance in treatment planning for implants. The purpose of this study was to evaluate the buccal plate thickness in posterior dentate areas of both the maxilla and mandible using cone beam computed tomography in order to estimate the approximate distributions of this anatomic variable.MethodsTwo hundred and sixty‐five subjects were included for a total of nine hundred and thirty‐four roots assessed by cone beam computed tomography. CBCT scans were taken and evaluated at the ideal buccolingual cross‐sections of each root at 1 mm, 3 mm, and 5 mm apical to the alveolar crest to measure buccal plate thickness. Data are reported by geometric means and 95% confidence intervals.ResultsBoth arches demonstrated increasing buccal plate thickness from anterior to posterior. Maxillary teeth had a significant decrease in thickness from coronal to apical along the tooth root (P < 0.001), except at second molars. The first premolar and mesial root of the first molar were significantly thinner than all other roots in the maxilla. Conversely, the mandible demonstrated a significant increase in buccal plate thickness from coronal to apical (P < 0.001). The premolars were significantly thinner than all other roots. Age and sex were found to have limited impact on buccal plate thickness in both arches.ConclusionsBuccal plate thickness is highly dependent upon the arch position, tooth location, and measurement point, but age and sex have limited impact.
Spirometric prediction equations and the relationship between metabolic syndrome and spirometric parameters from an island in Fujian, China
Authors: Chen Yu‐Sheng , Li Xiao‐Qin , Li Hong‐Ru , Yu Xiao‐Li , Lu Feng‐Feng , Huang Li‐Ping , Miao Yan , Wang Gui‐Qing , Lin Xiao , Lian Shuang‐Qing , Lin Yun‐Hua , Zhang Xiang‐E , Liu Ting , Wu Yan‐Ling 
Published: September 2015

AbstractBackgroundWe investigated risk factors for decreased lung function among Chinese island residents (≥30 years) to determine the relationship between metabolic syndrome (MS) and decreased lung function.MethodsFrom October 17, 2011 to November 1, 2011, 2607 residents aged ≥30 years who lived on the Huangqi Peninsula of Fujian were enlisted by random cluster sampling. They completed a questionnaire designed according to the Burden of Obstructive Lung Disease (BOLD) questionnaire, and underwent physical examination, blood test, and lung function evaluation. We constructed spirometric prediction equations for forced vital capacity (FVC) and forced expiratory volume in one second (FEV1), determined the lower limits of normal for FVC, FEV1 and FEV1/FVC, and examined the relationship between lung function and MS.ResultsPrediction equations for normal island residents were as follows:

FVC (L) = −0.023 × age (years) + 0.042 × height (cm) + 0.641 × weight (kg) – 3.607 (males);
FVC (L) = −0.017 × age (years) + 0.030 × height (cm) + 0.009 × weight (kg) – 1.741 (females);
FEV1 (L) = −0.023 × age (years) + 0.040 × height (cm) + 0.010 × weight (kg) – 2.999 (males);
FEV1 (L) = −0.017 × age (years) + 0.026 × height (cm) + 0.007 × weight (kg) −1.135 (females).
The odds ratio for MS for increased risk of decreased FVC was 4.623 (95%CI =3.626–5.894, P<0.001), and for increased risk of decreased FEV1 was 3.043 (95%CI =2.447–3.785, P<0.001).ConclusionsMS is a risk factor for decreased lung function in island residents ≥30 years old.
Breast metastasis and lung large‐cell neuroendocrine carcinoma: first clinical observation
Authors: Papa Anselmo , Rossi Luigi , Verrico Monica , Di Cristofano Claudio , Moretti Valentina , Strudel Martina , Zoratto Federica , Minozzi Marina , Tomao Silverio 
Published: September 2015

AbstractBackground and AimsThe lung large‐cell neuroendocrine carcinoma (LCNEC) is a very rare aggressive neuroendocrine tumor with a high propensity to metastasize and very poor prognosis. We report an atypical presentation of lung LCNEC was diagnosed from a metastatic nodule on the breast.MethodsOur patient is a 59‐years‐old woman that presented in March 2014 nonproductive cough. A CT scan showed multiple brain, lung, adrenal gland and liver secondary lesions; moreover, it revealed a breast right nodule near the chest measuring 1.8 cm. The breast nodule and lung lesions were biopsied and their histology and molecular diagnosis were LCNEC of the lung. To our knowledge, this is the first documented case of breast metastasis from LCNEC of the lung.ResultsFurthermore, breast metastasis from extramammary malignancy is uncommon and its diagnosis is difficult but important for proper management and prediction of prognosis. Therefore, a careful clinical history with a thorough clinical examination is needed to make the correct diagnosis. Moreover, metastasis to the breast should be considered in any patient with a known primary malignant tumor history who presents with a breast lump. Anyhow, pathological examination should be performed to differentiate the primary breast cancer from metastatic tumor.ConclusionTherefore, an accurate diagnosis of breast metastases may not only avoid unnecessary breast resection, more importantly it is crucial to determine an appropriate and systemic treatment.
A Bootstrap Mechanism for Response Masking in Remote Analysis Systems
Authors: Muralidhar Krishnamurty , O'Keefe Christine M. , Sarathy Rathindra 
Published: September 2015

ABSTRACTNational Statistical Agencies and other data custodian agencies hold a wealth of data regarding individuals and organizations, collected from censuses, surveys and administrative sources. In many cases, these data are made available to external researchers, for the investigation of questions of social and economic importance. To enhance access to this information, several national statistical agencies are developing remote analysis systems (RAS) designed to accept queries from a researcher, run them on data held in a secure environment, and then return the results. RAS prevent a researcher from accessing the underlying data, and most rely on manual checking to ensure the responses have acceptably low disclosure risk. However, the need for scalability and consistency will increasingly require automated methods. We propose a RAS output confidentialization procedure based on statistical bootstrapping that automates disclosure control while achieving a provably good balance between disclosure risk and usefulness of the responses. The bootstrap masking mechanism is easy to implement for most statistical queries, yet the characteristics of the bootstrap distribution assure us that it is also effective in providing both useful responses and low disclosure risk. Interestingly, our proposed bootstrap masking mechanism represents an ideal application of Efron's bootstrap—one that takes advantage of all the theoretical properties of the bootstrap, without ever having to construct the bootstrap distribution.
Managing a Portfolio of Product Development Projects under Resource Constraints
Authors: Browning Tyson R. , Yassine Ali A. 
Published: September 2015

ABSTRACTManagers of product development (PD) project portfolios face difficult decisions in allocating limited resources to minimize project or portfolio delay. Although PD projects are highly iterative (cyclical), almost all of the vast literature on project scheduling assumes that projects are acyclical. This article addresses this gap with a comprehensive analysis of 31 priority rules (PRs) on 18,480 portfolios containing 55,440 iterative projects. We find that the best PRs for iterative project portfolios differ significantly from those for acyclical ones, and that the best PRs at the project level differ from those at the portfolio level. The best PR depends on project and portfolio characteristics such as network density, iteration intensity, resource loading profile, and amount of resource contention. In particular, by amplifying the effects of iteration, high‐density networks hold dramatically different implications for iterative projects. Moreover, the best PR also differs depending on whether the objective is to minimize the average delay to all projects or to minimize delay to the overall portfolio. Thus, a project or portfolio manager who uses the same PR on all occasions will exhibit unnecessarily poor performance in most cases.
Neurodevelopmental, emotional, and behavioural problems in Duchenne muscular dystrophy in relation to underlying dystrophin gene mutations
Authors: Ricotti Valeria , Mandy William P L , Scoto Mariacristina , Pane Marika , Deconinck Nicolas , Messina Sonia , Mercuri Eugenio , Skuse David H , Muntoni Francesco 
Published: September 2015

AimDuchenne muscular dystrophy (DMD) is associated with neuropsychiatric disorders. The aim of the study was to characterize the DMD neuropsychiatric profile fully and to explore underlying genotype/phenotype associations.MethodOne hundred and thirty males with DMD (mean age 9y 10mo, range 5–17y) in four European centres were included and completed IQ assessment and a neurodevelopmental‐screening questionnaire. Of these, 87 underwent comprehensive neuropsychiatric assessment using structured diagnostic interview and parent‐reported questionnaires.ResultsThe overall mean score on the neurodevelopmental questionnaire was significantly abnormal compared with the general population of children (p<0.001). On average, intelligence was below the population mean, with intellectual disability observed in 34 males (26%). Autistic spectrum disorder was identified in 18 (21%), hyperactivity in 21 (24%), and inattention in 38 (44%). Clinical levels of internalizing and externalizing problems were observed in 21 (24%) and 13 (15%) respectively. Over a third of males scored more than two measures of emotional, behavioural, or neurodevelopmental problems. Males with mutations at the 3′ end of the DMD gene affecting all protein isoforms had higher rates of intellectual disability and clusters of symptoms.InterpretationMales with DMD are at very high risk of neuropsychiatric disturbance, and this risk appears to increase with mutations at the 3′ end of the gene. Patterns of symptom clusters suggest a DMD neuropsychiatric syndrome, which may require prompt evaluation and early intervention.
Research on fatigue crack propagation behaviour of 4003 ferritic stainless steel based on infrared thermography
Authors: Zhang H. X. , Wei C. Y. , Yan Z. F. , Wang W. X. , Guo S. F. , Zhou Y. G. 
Published: September 2015

AbstractFatigue crack propagation (FCP) behaviour of 4003 ferritic stainless steel was investigated using infrared thermography. Four stages of superficial temperature evolution were observed during the FCP tests: an initial temperature decrease stage, a temperature equilibrium stage, a slow temperature increase stage and an abrupt temperature increase stage; a thermal model is developed to explain the observed temperature evolution. The experimental results indicate that: when the range of stress intensity factor (ΔK) is at a low level where the crack is located in slow propagation region, thermoelastic effect will be in dominant status; when the ΔKis at a high level where the crack is located in stable propagation region, the temperature rise can be used to describe FCP rate. The fatigue fracture surfaces were examined using scanning electron microscope (SEM) in order to understand the effect of the fatigue mechanisms on temperature variation.
Experiments and model predictions for fatigue crack propagation in riveted lap‐joints with multiple site damage
Authors: Galatolo R. , Lazzeri R. 
Published: September 2015

AbstractIn this paper, the growth of long fatigue cracks up to failure in aircraft components is studied. A deterministic model is presented, able to simulate the growth of fatigue through cracks located at rivet holes in lap‐joint panels. It also includes criteria to assess the link‐up of collinear adjacent cracks in a MSD scenario. To validate the model, a fatigue test campaign was carried out on riveted lap‐joint specimens in order to produce experimental crack growth and link‐up data. Accurate measurements of naturally occurred surface cracks were automatically performed by the Image Analysis technique, thus allowing the tests to run 24 h a day. The comparison between experimental tests and numerical simulations is good, thus confirming the model as a useful tool for the assessment of fatigue life of aircraft riveted joints.
The health of parents with and without intellectual impairment in the UK
Authors: Emerson E. , Llewellyn G. , Hatton C. , Hindmarsh G. , Robertson J. , Man W. Y. N. , Baines S. 
Published: September 2015

AbstractBackgroundLittle is known about the health and well‐being of the ‘hidden majority’ of parents with mild intellectual disability (ID), who are less likely to be in contact with disability services.MethodWe sought to add to knowledge in this area by examining the health and living conditions of parents with and without intellectual impairment in a large contemporary nationally representative sample of UK parents aged between 16 and 49 years old (n = 14 371).ResultsOur results indicated that, as expected, parents with intellectual impairment were at significantly greater risk than other parents of having poorer self‐reported general, mental and physical health. They were also at significantly greater risk of experiencing higher rates of household socio‐economic disadvantage and environmental adversities and lower rates of neighbourhood social capital and intergenerational support. Adjusting risk estimates to take account of between group differences in household socio‐economic disadvantage eliminated statistically significant differences in health status between parents with and without intellectual impairment on all but one indicator (obesity). Further adjusting risk estimates to take account of between group differences in neighbourhood adversity, neighbourhood social capital and intergenerational support had minimal impact on the results.ConclusionsThat controlling for between‐group differences in exposure to socio‐economic disadvantage largely eliminated evidence of poorer health among parents with intellectual impairment is consistent with the view that a significant proportion of the poorer health of people with IDs may be attributable to their poorer living conditions rather than biological factors associated with ID per se.
Differentiating the extent of cartilage repair in rabbit ears using nonlinear optical microscopy
Authors: ZHU X.Q. , XU Y.H. , LIAO C.X. , LIU W.G. , CHENG K.K. , CHEN J.X. 
Published: September 2015

SummaryNonlinear optical microscopy (NLOM) was used as a noninvasive and label‐free tool to detect and quantify the extent of the cartilage recovery. Two cartilage injury models were established in the outer ears of rabbits that created a different extent of cartilage recovery based on the presence or absence of the perichondrium. High‐resolution NLOM images were used to measure cartilage repair, specifically through spectral analysis and image texture. In contrast to a wound lacking a perichondrium, wounds with intact perichondria demonstrated significantly larger TPEF signals from cells and matrix, coarser texture indicating the more deposition of type I collagen. Spectral analysis of cells and matrix can reveal the matrix properties and cell growth. In addition, texture analysis of NLOM images showed significant differences in the distribution of cells and matrix of repaired tissues with or without perichondrium. Specifically, the decay length of autocorrelation coefficient based on TPEF images is 11.2 ± 1.1 in Wound 2 (with perichondrium) and 7.5 ± 2.0 in Wound 1 (without perichondrium), indicating coarser image texture and faster growth of cells in repaired tissues with perichondrium (p < 0.05). Moreover, the decay length of autocorrelation coefficient based on collagen SHG images also showed significant difference between Wound 2 and 1 (16.2 ± 1.2 vs. 12.2 ± 2.1, p < 0.05), indicating coarser image texture and faster deposition of collagen in repaired tissues with perichondrium (Wound 2). These findings suggest that NLOM is an ideal tool for studying cartilage repair, with potential applications in clinical medicine. NLOM can capture macromolecular details and distinguish between different extents of cartilage repair without the need for labelling agents.
Female sex hormones modulate Porphyromonas gingivalislipopolysaccharide‐induced Toll‐like receptor signaling in primary human monocytes
Authors: Jitprasertwong P. , Charadram N. , Kumphune S. , Pongcharoen S. , Sirisinha S. 
Published: September 2015

Background and ObjectiveFemale sex hormones are elevated and are potential host response modifiers during pregnancy. Modulation of immune responses by estrogen and progesterone may be responsible for periodontal inflammation. Therefore, we aimed to investigate the role of β‐estradiol and progesterone in human monocyte immune responses, at cellular and molecular levels, to identify their role as a possible immunological link between pregnancy and periodontal disease.Material and MethodsPrimary human monocytes were purified from human peripheral blood mononuclear cells by adherent method. Expression of Toll‐like receptor (TLR) 2, 4 and CD14 was analyzed by flow cytometry. TLR2, TLR4, cyclooxygenase‐2 (COX2), nuclear factor‐kappa B (NF‐κB) and NF‐κB inhibitor‐alpha mRNA expressions were measured using real‐time reverse transcriptase–polymerase chain reaction and prostaglandin E2 secretion was assayed by enzyme‐linked immunosorbent assay. NF‐κB expression was also examined by immunofluorescence. Western blotting was performed to determine the activation of mitogen‐activated protein kinase pathway.ResultsWe report herein that both β‐estradiol and progesterone significantly reduced TLR2 expression at both protein and mRNA levels but had less of an effect on TLR4 expression in primary human monocytes. We also found that the hormones decreased monocyte cell surface protein expression of CD14. Significantly, β‐estradiol and progesterone dose‐dependently downregulated monocyte expression of COX2 mRNA. Pretreatment monocytes with β‐estradiol or progesterone reduced effects of Porphyromonas gingivalis lipopolysaccharide (LPS) on COX2 mRNA expression and decreased prostaglandin E2 secretion by the monocytes. Furthermore, we demonstrated that both β‐estradiol and progesterone inhibited P. gingivalis LPS‐induced NF‐κB signaling pathway through the upregulation of NF‐κB inhibitor‐alpha expression. However, neither β‐estradiol nor progesterone altered the phosphorylation of the p38, the extracellular signal‐regulated kinase 1/2 and the c‐Jun N‐terminal activated kinase in P. gingivalis LPS‐stimulated monocytes. Thus, the inhibitory effects of these hormones on the response of human monocytes to P. gingivalis LPS appear to be independent on mitogen‐activated protein kinase signaling pathway.ConclusionThe results of the present study suggest that β‐estradiol and progesterone could influence the immune response of human monocytes to periodontal pathogens and this process may have a role in the clinical manifestations of periodontal disease associated with pregnancy.