bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current philosophy in the surgical management of neck metastases for head and neck squamous cell carcinoma
Authors: Coskun H. Hakan , Medina Jesus E. , Robbins K. Thomas , Silver Carl E. , Strojan Primož , Teymoortash Afshin , Pellitteri Phillip K. , Rodrigo Juan P. , Stoeckli Sandro J. , Shaha Ashok R. , Suárez Carlos , Hartl Dana M. , de Bree Remco , Takes Robert P. , Hamoir Marc , Pitman Karen T. , Rinaldo Alessandra , Ferlito Alfio 
Published: March 2014

AbstractNeck dissection is an important treatment for metastases from upper aerodigestive carcinoma; an event that markedly reduces survival. Since its inception, the philosophy of the procedure has undergone significant change from one of radicalism to the current conservative approach. Furthermore, nonsurgical modalities have been introduced, and, in many situations, have supplanted neck surgery. The refinements of imaging the neck based on the concept of neck level involvement has encouraged new philosophies to evolve that seem to benefit patient outcomes particularly as this relates to diminished morbidity. The purpose of this review was to highlight the new paradigms for surgical removal of neck metastases using an evidence‐based approach. © 2014 Wiley Periodicals, Inc. Head Neck 37: 915–926, 2015
EFFECTS OF AN INTERVENTION TO PROMOTE SOCIOEMOTIONAL DEVELOPMENT IN TERMS OF ATTACHMENT SECURITY: A STUDY IN EARLY INSTITUTIONALIZATION IN CHILE
Authors: Lecannelier Felipe , Silva Jaime R. , Hoffmann Marianela , Melo Rolando , Morales Raquel 
Published: March 2014

ABSTRACTThe Chilean government commissioned a quasi‐experimental study with a pre‐/postintervention design that had two general aims: (a) to assess infants’ psychoaffective developmental levels (pre‐intervention phase) and (b) to evaluate whether an intervention based on the promotion of socioemotional development modifies the infant's psychoaffective development. Sixty‐two institutionalized infants and their alternative caregivers were evaluated at a pre‐intervention stage. An intervention then took place, with the caregivers trained according to an “attachment sensitivity manual.” Results showed normal ranges of psychomotor development (64% normal, 9% delayed) and a very high frequency of attachment insecurity, as compared to the normative population (53%).The intervention significantly improved social orientation and object orientation as well as activity and reactivity levels. We conclude that although institutionalized infants in Chile do not exhibit high levels of atypical attachment, socioemotional deterioration may lead to vulnerability in present and future development. Finally, the scope of this study affected public policies regarding children, initiating a change to a foster family system and a variety of modifications in the strategies for adopting institutionalized infants.
GLOBAL RESEARCH, PRACTICE, AND POLICY ISSUES ON THE CARE OF INFANTS AND YOUNG CHILDREN AT RISK: THE ARTICLES IN CONTEXT
Authors: McCall Robert B. , Groark Christina J. , Rygaard Niels P. 
Published: March 2014

ABSTRACTThis Special Issue includes articles that contribute to (a) the global research base pertaining to the development of infants and toddlers at risk, primarily those who are institutionalized in lower resource countries; (b) interventions in institutions and to promote family alternatives to institutionalization; and (c) attempts to create modern child welfare systems emphasizing family care in entire states and countries. This introduction places these articles into the broader contexts of the literature in these three domains of interest. Across the world, urbanization, migration, armed conflict, epidemics, and famine disrupt families. Add poverty, abuse, neglect, and parental incapacity due to substance abuse and mental health problems, and the result is millions of children without parental care who come under governmental responsibility, often to be reared in institutions, and at risk for long‐term developmental deficiencies and problems. Over the last 2 decades and especially recently, national and international governments and nongovernment organizations have increased efforts to help such children, especially those in low‐resource countries. Two types of efforts have been made: one to improve the quality of care provided by institutions and the other to minimize the use of institutions and promote family residential care alternatives. The latter effort includes preventing family separations in the first place, reunification of children with birth families, and developing systems of kinship care, foster care, and adoption. This Special Issue of IMHJ is devoted to reports pertaining to issues in the research knowledge base, program practices, and countrywide policies for infants and young children at risk. We attempt in this introduction to place these reports in the broader context of this field, identify their unique contributions, and highlight lessons learned that can contribute to improved care practices and better child welfare systems.
Coordinated Regulation of Retinoic Acid Signaling Pathway by KDM5B and Polycomb Repressive Complex 2
Authors: Zhang Yu , Liang Jing , Li Qian 
Published: March 2014

ABSTRACTPolycomb repressive complex 2 (PRC2) is a critical epigenetic regulator in many biological processes, including maintenance of cell identity, stem cell self‐renewal, differentiation, and deregulation of PRC2 is often observed in human cancers and diseases. Here we report that KDM5B (PLU‐1/JARID1B), a histone lysine demethylase of Jumonji family, associates with PRC2 and colocalizes with PRC2 in nuclear bodies, and their physical association is dependent on direct interaction between KDM5B and the SUZ12 component of PRC2. Interestingly, co‐occupancy of KDM5B and PRC2 was evidenced at the conserved cis‐regulatory DNA element on retinoic acid (RA) responsive genes. Transcription readout and in vitro pull‐down experiments suggest that KDM5B is an essential co‐activator, but not a co‐repressor, for the RA signaling, and the interface between KDM5B's JMJC domain and retinoic acid receptor α (RARα) is crucial for RA‐mediated gene expression. Detailed chromatin immunoprecipitation assays addressed the seemingly paradox by revealing a biphasic effect of KDM5B on RA‐induced gene activation through decoupled H3K4me3 demethylation and PRC2‐antagonizing activities. These results demonstrate that KDM5B and PRC2 regulate RA signaling cascade in a cooperative and orchestrated fashion. J. Cell. Biochem. 115: 1528–1538, 2014. © 2014 Wiley Periodicals, Inc.
Inhibition of AMPK/Autophagy Potentiates Parthenolide‐Induced Apoptosis in Human Breast Cancer Cells
Authors: Lu Can , Wang Wenwen , Jia Yongsheng , Liu Xiaodong , Tong Zhongsheng , Li Binghui 
Published: March 2014

ABSTRACTParthenolide is the main bioactive component in feverfew, a common used herbal medicine, and has been extensively studied in relation to its anti‐cancer properties. However there have been very few in‐depth studies of the activities of this compound at the molecular level. Here, we showed that parthenolide increased reactive oxygen species (ROS), induced cell death, activated AMPK and autophagy, and led to M phase cell cycle arrest in breast cancer cells. Removal of ROS inhibited all parthenolide‐associated events, such as cell death, AMPK activation, autophagy induction, and cell cycle arrest. Blockade of autophagy relieved cell cycle arrest, whereas inhibition of AMPK activity significantly repressed the induction of both autophagy and cell cycle arrest. These observations clearly showed that parthenolide‐driven ROS activated AMPK‐autophagy pathway. Furthermore, inhibition of either AMPK or autophagy significantly potentiated parthenolide‐induced apoptosis. Therefore, our results show that parthenolide activates both apoptosis pathway and AMPK‐autophagy survival pathway through the generation of ROS, and that suppression of AMPK or autophagy can potentially enhance the anti‐cancer effect of parthenolide on breast cancer cells. J. Cell. Biochem. 115: 1458–1466, 2014. © 2014 Wiley Periodicals, Inc.
Female Labour Supply in A Developing Economy: A Tale from A Primary Survey
Authors: Pradhan Basanta K. , Singh Shalabh K. , Mitra Arup 
Published: March 2014

AbstractThe U‐shaped relationship between economic development and female work force participation rate may be explained at the household level in terms of the interaction between social factors and the income of the household. The social attitude and income are likely to be influenced by education, which augments the income on the one hand and on the other shifts women from stigmatised jobs to non‐stigmatised jobs and also reduces the adverse social response towards women participation in the labour market. The shift across sectors of employment is also motivated by education, implying positive associations between education and high productivity jobs. Copyright © 2014 John Wiley & Sons, Ltd.
Composted organic wastes from the pharmaceutical and agro‐food industries induce soil bioactivity and nodulation in alfalfa
Authors: Fornes Fernando , Jaramillo Claudia X , García‐de‐la‐Fuente Rosana , Belda Rosa M , Lidón Antonio 
Published: March 2014

AbstractBACKGROUNDEnvironmentally friendly agriculture needs to reduce the use of synthetic fertilizers and to reclaim nutrients from organic wastes. In this study the effect of five doses (0, 12, 24, 48 and 96 t ha−1) of two two‐phase olive mill waste (TPOMW)‐based composts on the bioactivity and chemical characteristics of an agricultural soil and their potential to fertilize alfalfa (Medicago sativa) and stimulate nodulation were assessed during a two‐year incubation experiment. The two composts were prepared either with the olive mill waste alone (compost A), which served as control, or mixed with a liquid fatty‐proteinaceous hydrolyzate waste (FPH) from the pharmaceutical industry (compost AH).RESULTSCompost AH resulted in greater N immobilization than compost A because the former supplied the soil with easily degradable C and N, which increased microbial biomass and activity. Both compost mineralizations during the first year of incubation supplied the soil with more nutrients (mainly N), more so with A than with AH. Nevertheless, plant growth was similar in soils amended with either A or AH. Both composts induced nodulation similarly and the highest dose (96 t ha−1) increased the formation of nodules by a factor of 11 compared with the four lower doses.CONCLUSIONTPOMW serves as an effective ground material for co‐composting with liquid wastes such as FPH. TPOMW supplies key nutrients and stimulates nodulation in alfalfa. © 2014 Society of Chemical Industry
A prospective randomized comparison between pylorus‐ and subtotal stomach‐preserving pancreatoduodenectomy on postoperative delayed gastric emptying occurrence and long‐term nutritional status
Authors: Matsumoto Ippei , Shinzeki Makoto , Asari Sadaki , Goto Tadahiro , Shirakawa Sachiyo , Ajiki Tetsuo , Fukumoto Takumi , Suzuki Yasuyuki , Ku Yonson 
Published: March 2014

Background and ObjectivesPylorus‐preserving pancreatoduodenectomy (PPPD) has been associated with a high incidence of delayed gastric emptying (DGE). There are few studies comparing DGE associated with PPPD and subtotal stomach‐preserving pancreatoduodenectomy (SSPPD). Moreover, differences between the procedures with respect to long‐term results have not been reported. A prospective randomized study was conducted to compare perioperative complications and long‐term nutritional status with PPPD and SSPPD.MethodsOne hundred patients with periampullary lesions were randomized to receive either PPPD (n = 50) or SSPPD (n = 50). All patients were followed up for 3 years after surgery or to the time of recurrence to evaluate nutritional status for the study. The effects of the procedure, age, and malignancy on changes in nutritional indicators were estimated with linear mixed models. This study was registered at UMIN Clinical Trials Registry (UMIN 000012337).ResultsThe incidence of DGE assessed by the International Study Group of Pancreatic Surgery was 20% with PPPD and 12% with SSPPD (P = 0.414). There were no significant differences between the two procedures on postoperative serum albumin levels, serum total cholesterol levels, and body mass index during the 3‐year follow‐up period.ConclusionsSSPPD is equally effective in DGE occurrence rate and long‐term nutritional status comparing to PPPD. J. Surg. Oncol 2014; 109:690–696. © 2014 Wiley Periodicals, Inc.
Simulation of piston ring tribology with surface texturing for internal combustion engines
Authors: Zavos Anastasios B. , Nikolakopoulos Pantelis G. 
Published: March 2014

AbstractDesign of piston rings is a very crucial subject in the field of internal combustion engines. In the present paper, a numerical model is created using the Navier–Stokes equations. Fluid–structure interaction analysis is performed in order to calculate the structural integrity of the ring for several engine operational conditions and texturing patterns. This paper illustrates the hydrodynamic friction force under various surface artificial texturing in terms of spherical and rectangular microdimples. Piston ring stress analysis is also investigated due to gas leakage. Results show a substantial reduction of the friction using rectangular texturing and less reduction using spherical texturing. The rectangular microdimple parameters were considered to obtain a better friction reduction with the following configurations: Hd = 4 µm, ρτ = 0.61, λ = 20 and s = 0.004. Each rectangular texture cell is defined by the dimple depth, Hd; the texture density, ρτ; the dimple aspect ratio, λ; and the relative dimple depth, s. Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis and Optoelectronic Properties of Novel Polyamides with 2‐Naphthyldiphenylamine Units
Authors: Hsiao Sheng‐Huei , Yeh Su‐Jung 
Published: March 2014

A new series of electroactive polyamides is synthesized from N,N′‐bis(4‐aminophenyl)‐N,N′‐di‐2‐naphthyl‐1,4‐phenylenediamine (2) with four dicarboxylic acids via the phosphorylation polyamidation technique. These polyamides are amorphous with good solubility in many organic solvents and can be solution‐cast into flexible and strong films. They exhibit moderately high thermal stability with glass‐transition temperatures in the range of 247–289 °C. The polyamide 4a derived from a cycloaliphatic dicarboxylic acid reveals stronger fluorescence emission than those derived from aromatic ones, and it also shows a marked solvent effect on the fluorescence profile. All the electroactive polymer films show reversible electrochemical oxidation accompanied by strong color changes from the colorless neutral state to yellowish–green and blue oxidized states.
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Cyclic Amphiphilic Random Copolymers Bearing Azobenzene Side Chains: Facile Synthesis and Topological Effects on Self‐Assembly and Photoisomerization
Authors: Cai Ye , Lu Jinjie , Zhou Feng , Zhou Xiaoji , Zhou Nianchen , Zhang Zhengbiao , Zhu Xiulin 
Published: March 2014

In this article, well‐defined cyclic amphiphilic random copolymers bearing azobenzene side chains and pendent carboxyl moieties, cyclic‐P(BHMEm‐co‐AAn)s, are synthesized by combining atom transfer radical polymerization (ATRP) with Cu(I)‐catalyzed azide/alkyne cycloaddition (CuAAC) “click” reaction and selective hydrolysis of tert‐butyl ester. Successful synthesis of the cyclic‐P(BHMEm‐co‐AAn)s is fully characterized and verified via conventional gel permeation chromatography, triple detection gel permeation chromatography, nuclear magnetic resonance, Fourier transform infrared, and matrix‐assisted laser desorption ionization–time‐of‐flight mass spectrometry. The cyclic topology induces profound effects on the glass transition temperatures, self‐assembly behavior, and photoresponsive performance of the copolymers compared with their linear counterparts.
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A‐TWinnipeg: Pathogenesis of rare ATM missense mutation c.6200C>A with decreased protein expression and downstream signaling, early‐onset dystonia, cancer, and life‐threatening radiotoxicity
Authors: Nakamura Kotoka , Fike Francesca , Haghayegh Sara , Saunders‐Pullman Rachel , Dawson Angelika J. , Dörk Thilo , Gatti Richard A. 
Published: March 2014

AbstractWe studied 10 Mennonite patients who carry the c.6200C>A missense mutation (p.A2067D) in the ATM gene, all of whom exhibited a phenotypic variant of ataxia‐telangiectasia (A‐T) that is characterized by early‐onset dystonia and late‐onset mild ataxia, as previously described. This report provides the pathogenetic evidence for this mutation on cellular functions. Several patients have developed cancer and subsequently experienced life‐threatening adverse reactions to radiation (radiotoxicity) and/or chemotherapy. As the c.6200C>A mutation is, thus far, unique to the Mennonite population and is always associated with the same haplotype or haplovariant, it was important to rule out any possible confounding DNA variant on the same haplotype. Lymphoblastoid cells derived from Mennonite patients expressed small amounts of ATM protein, which had no autophosphorylation activity at ATM Ser1981, and trace‐to‐absent transphosphorylation of downstream ATM targets. A‐T lymphoblastoid cells stably transfected with ATM cDNA which had been mutated for c.6200C>A did not show a detectable amount of ATM protein. The same stable cell line with mutated ATM cDNA also showed a trace‐to‐absent transphosphorylation of downstream ATM targets SMC1pSer966 and KAP1pSer824. From these results, we conclude that c.6200A is the disease‐causing ATM mutation on this haplotype. The presence of at least trace amounts of ATM kinase activity on some immunoblots may account for the late‐onset, mild ataxia of these patients. The cause of the dystonia remains unclear. Because this dystonia‐ataxia phenotype is often encountered in the Mennonite population in association with cancer and adverse reactions to chemotherapy, an early diagnosis is important.
Cardiac involvement in Dutch patients with sarcoglycanopathy: A cross‐sectional cohort and follow‐up study
Authors: Schade van Westrum Steven M. , Dekker Lukas R.C. , de Voogt Willem G. , Wilde Arthur A.M. , Ginjaar Ieke B. , de Visser Marianne , van der Kooi Anneke J. 
Published: March 2014

ABSTRACTIntroduction: The aim of this study is to describe the frequency, nature, severity, and progression of cardiac abnormalities in a cohort of Dutch sarcoglycanopathy patients. Methods: In this cross‐sectional cohort study, patients were interviewed using a standardized questionnaire and assigned a functional score. Electrocardiography (ECG), echocardiography, and 24‐h ECG were performed. Results: Twenty‐four patients with sarcoglycanopathy had a median age of 25 years (range, 8–59 years). Beta blockers were used by 13%, and 17% used angiotensin‐converting enzyme inhibitors. ECG abnormalities were present in 5 (21%), and 4 (17%) fulfilled the criteria for dilated cardiomyopathy (DCM). There were no significant differences in median age or severity of disease between patients with or without DCM. Eleven patients were examined earlier. Median follow‐up time was 10 years. Two of the 11 patients (18%) developed DCM during follow‐up. Conclusions: Seventeen percent of the patients with sarcoglycanopathy were found to have dilated cardiomyopathy. We recommend biannual cardiac monitoring, including ECG and echocardiography. Muscle Nerve 50: 909–913, 2014
Xenophagy in Helicobacter pylori‐ and Epstein–Barr virus‐induced gastric cancer
Authors: Zhang Lin , Sung Joseph JY , Yu Jun , Ng Siew C , Wong Sunny H , Cho Chi H , Ng Simon SM , Chan Francis KL , Wu William KK 
Published: March 2014

AbstractHelicobacter pylori and Epstein–Barr virus (EBV) account for roughly 80% and 10%, respectively, of gastric carcinomas worldwide. Autophagy is an evolutionarily conserved and intricately regulated cellular process that involves the sequestration of cytoplasmic proteins and organelles into double‐membrane autophagosomes that eventually fuse with lysosomes for degradation of the engulfed content. Emerging evidence indicates that xenophagy, a form of selective autophagy, plays a crucial role in the pathogenesis of H. pylori‐ and EBV‐induced gastric cancer. Xenophagy specifically recognizes intracellular H. pylori and EBV and physically targets these pathogens to the autophagosomal–lysosomal pathway for degradation. In this connection, H. pylori or EBV‐induced dysregulation of autophagy may be causally linked to gastric tumourigenesis and therefore can be exploited as therapeutic targets. This review will discuss how H. pylori and EBV infection activate autophagy and how these pathogens evade recognition and degradation by the autophagic pathway. Elucidating the molecular aspects of H. pylori‐ and EBV‐induced autophagy will help us better understand the pathogenesis of gastric cancer and promote the development of autophagy modulators as antimicrobial agents. Published by John Wiley & Sons, Ltd
Reliability and quality of water isotope data collected with a low‐budget rain collector
Authors: Prechsl Ulrich E. , Gilgen Anna K. , Kahmen Ansgar , Buchmann Nina 
Published: March 2014

RATIONALELow‐budget rain collectors for water isotope analysis, such as the 'ball‐in‐funnel type collector' (BiFC), are widely used in studies on stable water isotopes of rain. To date, however, an experimental quality assessment of such devices in relation to climatic factors does not exist.METHODSWe used Cavity Ring‐Down Spectrometry (CRDS) to quantify the effects of evaporation on the δ18O values of reference water under controlled conditions as a function of the elapsed time between rainfall and collection for isotope analysis, the sample volume and the relative humidity (RH: 31% and 67%; 25°C). The climate chamber conditions were chosen to reflect the warm and dry end of field conditions that favor evaporative enrichment (EE). We also tested the performance of the BiFC in the field, and compared our δ2H/δ18O data obtained by isotope ratio mass spectrometry (IRMS) with those from the Swiss National Network for the Observation of Isotopes in the Water Cycle (ISOT).RESULTSThe EE increased with time, with a 1‰ increase in the δ18O values after 10 days (RH: 25%; 25°C; 35 mL (corresponding to a 5 mm rain event); p <0.001). The sample volume strongly affected the EE (max. value +1.5‰ for 7 mL samples (i.e., 1 mm rain events) after 72 h at 31% and 67% RH; p <0.001), whereas the relative humidity had no significant effect. Using the BiFC in the field, we obtained very tight relationships of the δ2H/δ18O values (r2 ≥0.95) for three sites along an elevational gradient, not significantly different from that of the next ISOT station.CONCLUSIONSSince the chosen experimental conditions were extreme compared with the field conditions, it was concluded that the BiFC is a highly reliable and inexpensive collector of rainwater for isotope analysis. Copyright © 2014 John Wiley & Sons, Ltd.
Metalcarbonyl Complexes of Iron, Rhenium, and Manganese with 2‐, 3‐, or 4‐Pyridoyl (CO‐Pyridyl) Ligands
Authors: Weinrich Volker , Beck Wolfgang 
Published: March 2014

AbstractThe title complexes were obtained by reactions of [(η5‐C5H5)(CO)2Fe]–, [(η5‐C5H4CH3)(CO)2Fe]–, [Re(CO)5]–, or [Mn(CO)5]– with the mixed anhydride from the respective pyridine carboxylic acid and pivalic acid or with isonicotinic acid chloride, and were characterized by spectroscopic data and elemental analysis.