bluuebunny/crossref_metadata_2025_split huggingface dataset:
Relationship between Propionibacterium acnes Biotypes and Jumi‐haidoku‐to
Authors: Higaki Shuichi , Kitagawa Taro , Kagoura Masayori , Morohashi Masaaki , Yamagishi Takayoshi 
Published: April 2015

AbstractWe examined the relationship between Propionibacterium acnes biotypes and Jumi‐haidoku‐to (JHT). In all the P. acnes strains tested, the production of propionic acid (PA) and butyric acid (BA) was suppressed in a medium containing 1 mg/ml JHT compared with the control medium without JHT. There were no significant differences in the rates of decreased PA and BA production between P. acnes biotype 3 (B3) and the other biotypes or between isolates from mild skin rash and more severe skin rash. P. acnes B3 was the most commonly identified biotype. The clinical effects on acne due to the anti‐P. acnes lipase activity of JHT did not seem to be influenced by the degree of acne rash or the P. acnes biotype.
Crusted (Norwegian) Scabies in a Patient with Smoldering Adult T‐cell Leukemia
Authors: Takeshita Taizo , Takeshita Hiromichi 
Published: April 2015

AbstractCrusted (Norwegian) scabies is described in a patient with smoldering adult T‐cell leukemia (ATL). The patient is an 84‐year‐old Japanese woman who presented with widespread scaling over the trunk and limbs and crusted lesions on the scalp and ears. Microscopical examination of scrapings from the scalp and ears showed extraordinarily large numbers of scabies mites. The white blood cell count was 5.1 times 109/L with 6% abnormal lymphocytes with mature nuclei that showed convolution and lobulation. Anti‐HTLV‐I antibodies were positive. Southern blot analysis revealed that the cellular DNA extracted from this patient's peripheral blood cells, digested with Pst I, showed the same pattern of provirus genome as the DNA from ATL patients. A diagnosis of crusted scabies with smoldering ATL was made. It is possible that crusted scabies could be an opportunistic infection and a pre‐diagnostic sign of ATL.
A Case of Dermatomyositis Associated with Mechanic's Hand
Authors: Watanabe Chiharu , Okubo Yukari , Oh‐i Tsunao , Koga Michiyuki , Abe Haruo , Tawara Kouichirou , Tsuboi Norioki , Hayashi Toru 
Published: April 2015

AbstractA 67‐year‐old man was referred to the Department of Internal Medicine at Tokyo Medical University with interstitial pneumonia in July 1999. He presented with keratotic plaques on both palms and on the ventral and lateral sides of his fingers. Erythematous keratosis was observed on the dosal aspect of his fingers and metatarsophalangeal (MP) joints. Edematous erythema was seen on the patient's chest, back, and the extensor surfaces of his arms. Electromyography revealed a myogenic pattern and an increased level of myogenic enzymes was found in the blood. Histological findings of the ventral sides of his fingers showed hyperkeratosis and parakeratosis of the dermal tissue and liquefaction degeneration of the basal layer at the papilla. Based on these findings, the patient was given a diagnosis of dermatomyositis associated with mechanic's hand. A systemic examination confirmed interstitial pneumonia and carcinoma of the duodenal papilla. Mechanic's hand is a type of dermatitis associated with myopathy first reported by Stahl et al. in patients with collagen disease. We report herein the first documented case of mechanic's hand in Asians.
Benign Symmetrical Lipomatosis of the Hands
Authors: Yamamoto Koichiro , Ichimiya Makoto , Hamamoto Yoshiaki , Muto Masahiko 
Published: April 2015

AbstractBenign symmetrical lipomatosis (BSL) is a disease characterized by massively symmetrical fat deposits predominantly in the neck and shoulder girdle area. The disease is frequently associated with alcoholism, hepatopathy, glucose intolerance, hyperuricemia, and malignant tumors. We describe a patient with BSL of the dorsal surfaces of both hands.
A Case of Varicella Complicated by Cellulitis and Scarlet Fever Due to Streptococcus pyogenes
Authors: Oyake Shinichi , Oh‐i Tsunao , Koga Michiyuki 
Published: April 2015

AbstractWe report a 4‐year‐old boy with cellulitis and scarlet fever due to streptococcal infection following the onset of varicella. He developed a painful ulcer and subcutaneous induration on the left shoulder and a small, light‐red‐colored rash on the trunk at approximately the same time as the development of vesicles over the entire body. Streptococcus pyrogenes was isolated from samples from the posterior intranasal space and the ulcer on the shoulder. The clinical symptoms improved with the administration of antibiotics and intravenous drip infusion, but it took approximately one month from the first visit for the subcutaneous induration to disappear and the ulcer to heal with epithelialization. The complication of secondary streptococcal infection in varicella is relatively rare in Japan, but in Western countries there have been many reported cases of life‐threatening necrotizing fasciitis and necrotizing pyomyositis due to secondary streptococcal infection following varicella. Close attention should be paid to streptococcal infection as a complicaion of varicella.
Three Cases of Polyarteritis Nodosa Cutanea and a Review of the Literature
Authors: Gushi Akira , Hashiguchi Takaki , Fukumaru Keiko , Usuki Kazunari , Kanekura Takuro , Kanzaki Tamotsu 
Published: April 2015

AbstractWe describe three cases of polyarteritis nodosa cutanea (PNC) showing necrotizing arteritis and only cutaneous lesions without systemic symptoms or visceral involvement for eleven, six, and three years after the onset of the disease. Since it was first described, there has been continuous controversy as to whether PNC progresses to systemic PN. Some cases have been described which had begun with a cutaneous lesion and progressed to the systemic form 19 and 18 years after the onset of the disease, so we believe that long term follow‐up of this disease is essential.
Colchicine Treatment in a Patient with Neutrophilic Dermatosis Associated with Rheumatoid Arthritis
Authors: Youn Choon Shik , Hwang Ji Hwan , Cho Kwang Hyun , Yoon Tae Young 
Published: April 2015

AbstractNeutrophilic dermatoses (ND) are characterized by epidermal and dermal infiltrates of polymorphonuclear leukocytes (PMN), without any infectious or other detectable agents as a cause. We describe a case of ND, which very rapidly improved upon colchicine treatment. The patient was a 67‐year‐old female with an 8‐month history of dusky‐red, tender, swollen plaques and nodules with superimposed vesicles and bullae on the buttocks, hands, and ankles associated with rheumatoid arthritis. The diagnosis of ND was made on the basis of the clinical and histopathological features of the skin lesions. She was treated with 0.6 mg of oral colchicine twice daily. Within one week, the erythematous plaques and arthralgia began to recede and disappeared within four weeks. In our case, colchicine seemed to improve the signs and symptoms of ND and appeared to be more effective than the other drugs we had used.
A Case of Acinic Cell Adenocarcinoma on the Left Hemifacial Area
Authors: Whang Sung Won , Chang Sung‐Nam , Park Wook‐Hwa , Kim Soo‐Chan 
Published: April 2015

AbstractAcinic cell adenocarcinoma is a rare salivary gland tumor which predominantly occurs in the parotid gland. A 46‐year‐old man presented with a left preauricular mass of one month duration; the pathologic report showed acinic cell adenocarcinoma. He was transferred to the oral and maxillofacial surgery department, and a total parotidectomy was performed. We present this interesting case of acinic cell adenocarcinoma from the parotid gland with cutaneous involvement.
Sweet's Syndrome with Abscess‐like Lesions in a Patient with Acute Myelogenous Leukemia
Authors: Yoon Tae‐Young , Ahn Gwang‐Bum , Yang Tae‐Ho , Shin Hyoung‐Shik 
Published: April 2015

AbstractWe describe a 49‐year‐old man with acute myelogenous leukemia associated with Sweet's syndrome and abscess‐like lesions mimicking an infectious disease. Although blisters may be included in the clinical spectrum, frank non‐infectious abscesses have not been reported as far as we know. Clinicians should be familiar with this clinical and histopathologic variant of Sweet's syndrome. It is mandatory to make every effort to find an infectious cause for abscesses before a diagnosis of Sweet's syndrome is made.
Crop Coefficients, Growth Rates and Quality of Cool‐Season Turfgrasses
Authors: Aamlid T. S. , Knox J. W. , Riley H. , Kvalbein A. , Pettersen T. 
Published: April 2015

AbstractDetermination of crop coefficients (Kc), the ratio between actual (ETa) and reference evapotranspiration (ET0), is necessary to schedule irrigation. Our objective was to determine Kc, turf quality and growth rate under daily irrigation to field capacity (FC = −3 kPa tension) and drying. Minilysimeters installed in a green (mowing height 3–5 mm) and fairway (15 mm) were weighed during four periods of 4–10 days duration in 2009 and 2010. Crop coefficients on the second and subsequent days after irrigation were not significantly different among species and averaged 0.81 and 0.91 on green and fairway, respectively. On the first day after irrigation, the Kc varied from 1.67 to 2.85 and decreased in the order Agrostis capillaris > Festuca rubra ssp. litoralis > F. rubra ssp. commutata > A. stolonifera > A. canina on the green, and F. rubra ssp. litoralis > Lolium perenne > F.rubra ssp. rubra > Poa pratensis > F. rubra ssp. commutata on the fairway. Drying reduced the average daily height growth from 0.98 to 0.74 mm on the green and 1.97–1.72 mm on the fairway. Scores for turf quality were reduced but remained acceptable. Although the Kc during the first day after irrigation to FC may be overestimated due to latent soil heat and a possible oasis effect, we conclude that irrigation to FC should be avoided as it causes excessive water use.
Social Connections for Older People with Intellectual Disability in Ireland: Results from Wave One of IDS‐TILDA
Authors: McCausland Darren , McCallion Philip , Cleary Eimear , McCarron Mary 
Published: April 2015

BackgroundThe literature on influences of community versus congregated settings raises questions about how social inclusion can be optimised for people with intellectual disability. This study examines social contacts for older people with intellectual disability in Ireland, examining differences in social connection for adults with intellectual disability and other adults.Materials & MethodsData were drawn from the IDS‐TILDA study in Ireland. A nationally representative sample (n = 753) included adults aged 40 years and older, with additional comparison with general population participants. Predictors of social contacts were explored.ResultsResidence, level of intellectual disability and age were significant factors determining social contact. People in institutional residences, older respondents and those with severe/profound intellectual disability had the lowest levels of contact; older adults with intellectual disability had much lower rates than general population counterparts.ConclusionsCommunity‐dwelling people with intellectual disability have greater social contact than those living in institutions, but levels are below those for other adults in Ireland.
Survival outcomes in patients with multiple primary melanomas
Authors: Rowe C.J. , Law M.H. , Palmer J.M. , MacGregor S. , Hayward N.K. , Khosrotehrani K. 
Published: April 2015

AbstractBackgroundA substantial number of melanoma patients will develop multiple primary melanomas (MPM). Currently, little is known about the impact of MPM on survival.ObjectiveWe aimed to determine whether melanoma survival is worse for patients with MPM compared to those with a single invasive primary melanoma (SPM).Materials and methodsA cohort study was conducted. Patients were sourced from an Australian population, with follow‐up information collected retrospectively from registry data. Melanoma‐specific survival analysis was performed to find associated variables after adjustment for known prognostic factors, using four different models, each selecting a different index melanoma lesion.Results1068 stage I and II melanoma patients were followed up for a median of 24.4 years. MPM was found in 17.8% of the cohort (190 patients), more likely among males and older age groups. Other clinicopathological parameters were similar between the MPM and SPM (878 patients) cohorts. After adjustment for age, sex and Breslow thickness, MPM was a hazard for death from melanoma, across all models, reaching significance when considering the last invasive lesion as the index melanoma (HR = 2.76, P = 0.017).ConclusionPatients with multiple invasive lesions seem more at risk of death from melanoma, independent of known prognostic factors.
Escherichia coli populations in unpredictably fluctuating environments evolve to face novel stresses through enhanced efflux activity
Authors: Karve S. M. , Daniel S. , Chavhan Y. D. , Anand A. , Kharola S. S. , Dey S. 
Published: April 2015

AbstractThere is considerable understanding about how laboratory populations respond to predictable (constant or deteriorating environment) selection for single environmental variables such as temperature or pH. However, such insights may not apply when selection environments comprise multiple variables that fluctuate unpredictably, as is common in nature. To address this issue, we grew replicate laboratory populations of Escherichia coli in nutrient broth whose pH and concentrations of salt (NaCl) and hydrogen peroxide (H2O2) were randomly changed daily. After ~170 generations, the fitness of the selected populations had not increased in any of the three selection environments. However, these selected populations had significantly greater fitness in four novel environments which have no known fitness‐correlation with tolerance to pH, NaCl or H2O2. Interestingly, contrary to expectations, hypermutators did not evolve. Instead, the selected populations evolved an increased ability for energy‐dependent efflux activity that might enable them to throw out toxins, including antibiotics, from the cell at a faster rate. This provides an alternate mechanism for how evolvability can evolve in bacteria and potentially lead to broad‐spectrum antibiotic resistance, even in the absence of prior antibiotic exposure. Given that environmental variability is increasing in nature, this might have serious consequences for public health.
Weak photoperiodic response facilitates the biological invasion of the harlequin ladybird Harmonia axyridis (Pallas) (Coleoptera: Coccinellidae)
Authors: Reznik S. Ya. , Dolgovskaya M. Yu. , Ovchinnikov A. N. , Belyakova N. A. 
Published: April 2015

AbstractPhotoperiodic regulation of reproductive diapause in two invasive and two native populations of Harmonia axyridis and in one native population of Harmonia yedoensis was investigated in laboratory at 20°C, five photoperiods (day length of 10, 12, 14, 16 and 18 h) and two diets: (i) eggs of the Angoumois grain moth Sitotroga cerealella and (ii) the green peach aphid, Myzus persicae. Laboratory strains originated from native populations of H. axyridis from Irkutsk province of Siberia and H. yedoensis from South Korea showed a strong photoperiodic response: under short photoperiods (10–14 h and 10–12 h for H. axyridis and H. yedoensis, correspondingly), all females which fed on eggs and most of those fed on aphids did not start to lay eggs during 40 days after emergence, while under long photoperiods, all females fed on aphids and most of those fed on eggs oviposited. The photoperiodic response of H. axyridis from South Korea was less strong: on the both diets, the range of the photoperiodic response (the difference in the proportion of ovipositing females between the treatments with long and short days) was ca 40%. In the European (Czech Republic) and in the Caucasian (Sochi region, Russia) invasive populations of H. axyridis, the photoperiodic response was very weak: the proportion of females that started oviposition (when fed on aphids) or at least reproductive maturation (when fed on eggs) during 40 days after emergence was close to 100%, independently of the photoperiodic conditions. Obviously, instead of a rapid micro‐evolutionary adaptation of the critical day length to a new climate, the invasive populations of the harlequin ladybird decrease their dependence on photoperiod and thus the weak photoperiodic response of SE Asian population of H. axyridis can be considered as a pre‐adaptation further developed during the invasion.
Pressure and temperature conditions for crystallization of metamorphic allanite and monazite in metapelites: a case study from the Miyar Valley (high Himalayan Crystalline of Zanskar, NW India)
Authors: Goswami‐Banerjee S. , Robyr M. 
Published: April 2015

AbstractThe textural and chemical evolution of allanite and monazite along a well‐constrained prograde metamorphic suite in the High Himalayan Crystalline of Zanskar was investigated to determine the P–T conditions for the crystallization of these two REE accessory phases. The results of this study reveals that: (i) allanite is the stable REE accessory phase in the biotite and garnet zone and (ii) allanite disappears at the staurolite‐in isograd, simultaneously with the occurrence of the first metamorphic monazite. Both monazite and allanite occur as inclusions in staurolite, indicating that the breakdown of allanite and the formation of monazite proceeded during staurolite crystallization. Staurolite growth modelling indicates that staurolite crystallized between 580 and 610 °C, thus setting the lower temperature limit for the monazite‐forming reaction at ~600 °C. Preservation of allanite and monazite inclusions in garnet (core and rim) constrains the garnet molar composition when the first monazite was overgrown and subsequently encompassed by the garnet crystallization front. Garnet growth modelling and the intersection of isopleths reveal that the monazite closest to the garnet core was overgrown by the garnet advancing crystallization front at 590 °C, which establishes an upper temperature limit for monazite crystallization. Significantly, the substitution of allanite by monazite occurs in close spatial proximity, i.e. at similar P–T conditions, in all rock types investigated, from Al‐rich metapelites to more psammitic metasedimentary rocks. This indicates that major silicate phases, such as staurolite and garnet, do not play a significant role in the monazite‐forming reaction. Our data show that the occurrence of the first metamorphic monazite in these rocks was mainly determined by the P–T conditions, not by bulk chemical composition. In Barrovian terranes, dating prograde monazite in metapelites thus means constraining the time when these rocks reached the 600 °C isotherm.
A simple but precise method for quantitative measurement of the quality of the laser focus in a scanning optical microscope
Authors: TRÄGÅRDH J. , MACRAE K. , TRAVIS C. , AMOR R. , NORRIS G. , WILSON S.H. , OPPO G.‐L. , MCCONNELL G. 
Published: April 2015

SummaryWe report a method for characterizing the focussing laser beam exiting the objective in a laser scanning microscope. This method provides the size of the optical focus, the divergence of the beam, the ellipticity and the astigmatism. We use a microscopic‐scale knife edge in the form of a simple transmission electron microscopy grid attached to a glass microscope slide, and a light‐collecting optical fibre and photodiode underneath the specimen. By scanning the laser spot from a reflective to a transmitting part of the grid, a beam profile in the form of an error function can be obtained and by repeating this with the knife edge at different axial positions relative to the beam waist, the divergence and astigmatism of the postobjective laser beam can be obtained. The measured divergence can be used to quantify how much of the full numerical aperture of the lens is used in practice. We present data of the beam radius, beam divergence, ellipticity and astigmatism obtained with low (0.15, 0.7) and high (1.3) numerical aperture lenses and lasers commonly used in confocal and multiphoton laser scanning microscopy. Our knife‐edge method has several advantages over alternative knife‐edge methods used in microscopy including that the knife edge is easy to prepare, that the beam can be characterized also directly under a cover slip, as necessary to reduce spherical aberrations for objectives designed to be used with a cover slip, and it is suitable for use with commercial laser scanning microscopes where access to the laser beam can be limited.
Nidogen‐1 is a common target of microRNAs MiR‐192/215 in the pathogenesis of Hirschsprung's disease
Authors: Zhu Dongmei , Xie Hua , Li Hongxing , Cai Peng , Zhu Hairong , Xu Chao , Chen Pingfa , Sharan Ankur , Xia Yankai , Tang Weibing 
Published: April 2015

AbstractRecent studies have emphasized the important role of microRNA (miRNA) clusters and common target genes in disease progression. Despite the known involvement of the miR‐192/215 family in many human diseases, its biological role in Hirschsprung disease (HSCR) remains undefined. In this study, we explored the role of the miR‐192/215 family in the pathogenesis of HSCR. Quantitative real‐time PCR and western blotting measured relative expression levels of miRNAs, mRNAs, and proteins in 80 HSCR patients and 77 normal colon tissues. Targets were evaluated by dual‐luciferase reporter assays, and the functional effects of miR‐192/215 on human 293T and SH‐SY5Y cells were detected by the Transwell assay, CCK8 assay and flow cytometry. MiR‐192/215 was significantly down‐regulated in HSCR tissue samples, and their knockdown inhibited cell migration and proliferation in the human 293T and SH‐SY5Y cell lines. Nidogen 1 (NID1) was confirmed as a common target gene of miR‐192/215 by dual‐luciferase reporter gene assay and its expression was inversely correlated with that of miR‐192/215 in tissue samples and cell lines. Silencing of NID1 could rescue the extent of the suppressing effects by miR‐192/215 inhibitor. The down‐regulation of miR‐192/215 may contribute to HSCR development by targeting NID1.
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We proposed the following cascade for the proposed mechanism of miR‐192/215 in the pathogenesis of Hirschsprung disease (HSCR) by targeting Nidogen 1 (NID1). Aberrant expression of miR‐192/215 inhibits cell migration and cell proliferation via NID1. We think the miR‐192/miR‐215/NID1 signaling pathway may play an important role in the pathogenesis of HSCR.
CIDP‐like neuropathies in graft versus host disease
Authors: Cocito Dario , Romagnolo Alberto , Rosso Michela , Peci Erdita , Lopiano Leonardo , Merola Aristide 
Published: April 2015

AbstractCases of chronic inflammatory demyelinating poliradiculoneuropathy (CIDP) have been reported in hematopoietic stem cells transplantation complicated by graft versus host disease (GVHD). A systematic review of the CIDP‐like neuropathies associated with GVHD was conducted until January 2015, analyzing the clinical presentation and the response to different therapeutic regimens. Nineteen patients have been reported in literature including the present one. Fourteen subjects fulfilled the criteria for CIDP, whereas two cases presented with an asymmetric motor onset and one showed motor involvement only associated with anti‐ganglioside antibodies. In addition, two subjects already affected by CIDP developed a significant relapse after GVHD. This study reviews the literature data and reports one additional case of CIDP and GVHD, suggesting that the two clinical entities might share a similar immunological background.