bluuebunny/crossref_metadata_2025_split huggingface dataset:
Science, technology, engineering, & mathematics, curricular integration, and the story form
Authors: Krushelnycky Emily , Karrow Douglas D. 
Published: August 2024

AbstractAs science, technology, engineering, and mathematics (STEM) education continues to increase in popularity, it becomes imperative that generalist preservice teachers (PT) have both strong concept knowledge and pedagogical skills to properly support its integration. However, generalist PTs do not have enough knowledge or skills possessed by those in STEM's respective disciplines, impacting their perceptions of how the framework is disseminated. The finger, then, is pointed at PT education to provide the necessary education and training that would allow for high‐quality STEM education beginning at the elementary level. One novel approach to mitigate this problem is to introduce Kieran Egan's education theory on imagination (mythic understanding) and the theory of integrated curricula to PT. Throughout this philosophical inquiry, we explore integrated curriculum models, imagination (mythic understanding) and storytelling, illustrating how they may appear in a STEM‐oriented lesson within an elementary science PT course, and attend to the need for approachable, evidence‐based interventions regarding generalist PT STEM education.
How to manage patients with germline DDX41 variants: Recommendations from the Nordic working group on germline predisposition for myeloid neoplasms
Authors: Baliakas Panagiotis , Tesi Bianca , Cammenga Jörg , Stray‐Pedersen Asbjørg , Jahnukainen Kirsi , Andersen Mette Klarskov , Ågerstam Helena , Creignou Maria , Dybedal Ingunn , Raaschou‐Jensen Klas , Grønbæk Kirsten , Kilpivaara Outi , Lindberg Eva Hellström , Wartiovaara‐Kautto Ulla 
Published: August 2024

AbstractIncreasing recognition of germline DDX41 variants in patients with hematological malignancies prompted us to provide DDX41‐specific recommendations for diagnosis, surveillance, and treatment. Causative germline variants in the DDX41 predispose to the development of myeloid neoplasms (MNs), especially myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Almost 3%–5% of all patients with MDS or AML carry a pathogenic or likely pathogenic germline DDX41 variant, while half of them acquire a somatic second hit in the other allele. DDX41‐associated MNs exhibit unique clinical characteristics compared to other hematological malignancies with germline predisposition: MNs occur mostly at advanced age and follow an indolent clinical course. Male carriers are more prone to develop MDS or AML than females. DDX41‐associated MN is often hypoplastic, and the malignancy may be preceded by cytopenias.
Negative prior aquatic experiences and children's aquatic competency: Do parent perceptions differ from reality?
Authors: Calverley Hannah L. M. , Petrass Lauren A , Konjarski Loretta 
Published: August 2024

AbstractIssue AddressedAchieving aquatic competence is recommended for preventing childhood drownings, yet many children in Victoria, Australia do not meet aquatic benchmarks despite participating in swimming and water safety programs. While few studies have explored factors influencing aquatic competency development, negative prior aquatic experiences (NPAE) have surfaced as a potential influence. Research on children's NPAE has primarily focused on parental perceptions rather than the child's actual experiences.MethodsParents and children (aged 10–12 years) completed reliable surveys for background information and NPAE‐related data. Children also completed aquatic competency assessments against benchmark standards. Chi‐square tests determined relationships between NPAE and aquatic competency, and thematic analysis categorised themes related to perceptions of the child's NPAE.ResultsMost parents (82.9%) indicated their child had not had NPAE, while only half (51.0%) of children did not report NPAE. Children reporting NPAE often perceived incidents as nearly drowning (41%), encompassing swimming pool environments and underwater submersion. Similarly, parents reported varied situations, noting NPAE involving open water and the child's loss of control. Parent‐reported NPAE was associated with children less likely to achieve knowledge, continuous swimming, and survival competency benchmarks (p < .05). Children reporting NPAE were less likely to achieve underwater competencies (p < .05).ConclusionsThe disparity between parent and child perspectives of NPAE demonstrates the importance of considering both perspectives. This should assist in providing appropriate support for children to develop aquatic competencies.So What?Using NPAE data, practitioners can customise swim teaching approaches to address and prevent NPAE, particularly as many children associate their NPAE with pools, the common setting for aquatic education.
Workforce neurodiversity and workplace avoidance behavior: The role of inclusive leadership, relational energy, and self‐control demands
Authors: Iqbal Qaisar , Volpone Sabrina D. , Piwowar‐Sulej Katarzyna 
Published: August 2024

AbstractWe draw on job demands‐resources theory to develop and test a model that explores the direct and indirect (through relational energy) impact of inclusive leadership on workplace avoidance behaviors for neurodivergent employees. We also examine the moderating role of personal self‐control demands in the relationship between relational energy and workplace avoidance. We tested our model using partial least square ‐ structural equation modeling analysis with data collected using a time‐lagged data collection in a sample of 215 neurodiverse employees working in multinational companies across the Gulf Cooperation Council region (i.e., Saudi Arabia, United Arab Emirates, Oman). The findings demonstrate that inclusive leaders mitigate workplace avoidance behavior in neurodivergent employees. That is, inclusive leaders create an environment that contributes to the cultivation of employees' personal relational energy resources. Then, high levels of relational energy interact with employees' level of personal demands (i.e., impulse control, resisting distractions) to reduce workplace avoidance behaviors. Our work speaks to the integrated role of demands and resources in workplaces that can thwart avoidance behaviors for neurodivergent employees.
Preparation of silk fibroin‐derived hydrogels and applications in skin regeneration
Authors: Li Dipeng , Liang Renjie , Wang Yirong , Zhou Yanting , Cai Weibang 
Published: August 2024

AbstractPurposeTo compare different methods of preparing silk fibroin hydrogels, then summarize the applications of silk fibroin hydrogel‐based scaffolds in skin regeneration and finally discuss about future prospects to inspire people interested in this field.MethodsA narrative review of the relevant papers was conducted. Notably, for applications in skin regeneration, this review provides a categorized summary and discussion of studies from the past decade.ResultsSilk fibroin is a naturally occurring, biocompatible biomaterial that is easily producible. Thanks to its exceptional processability, silk fibroin has found diverse applications in skin regeneration. These applications encompass sponges, fiber fabrics, thin films, and hydrogels. Hydrogels, in particular, are noteworthy due to their water‐containing network structure, closely resembling natural tissues. They provide a biomimetic three‐dimensional growth environment for cells and have the capacity to incorporate growth factors. Consequently, there are abundant studies of silk fibroin hydrogel‐based scaffolds in skin regeneration. Besides, some commercialized medical devices are also made of silk fibroin.ConclusionSilk fibroin hydrogel could be prepared with multiple methods and it is widely used in constructing scaffolds for efficient skin regeneration. In the future, silk fibroin hydrogel‐based skin scaffolds could be more biomimetic and smart.
MAXTOF: An efficient calculation tool for precise optimization of MALDI‐TOF MS measurements in real time
Authors: Chang Ko‐Keng , Ko Yi‐Yu , Chou Po‐Yu , Lai Szu‐Hsueh , Wang Yi‐Sheng 
Published: August 2024

AbstractAn efficient calculation tool for rigorously optimizing the instrument parameters of matrix‐assisted laser desorption/ionization time‐of‐flight mass spectrometry (MALDI‐TOF MS) is demonstrated in this work. Optimization of MALDI‐TOF MS has been an experience‐based, time‐consuming process without a rigorous theoretical principle. Based on the comprehensive calculation model reported previously, we developed a software tool, MAXTOF, to rapidly determine instrument parameters providing ultimate mass resolving power (MRP). The software conducts big data analysis of most instrument parameters to predict the MRP, including instrument dimensions, voltages, mass‐to‐charge ratio of ions, and ion extraction delay. It can complete the calculation in seconds, providing parameters that serve as the starting point for subsequent optimization that greatly accelerates the optimization process. Experimental validation using a commercial instrument demonstrates MAXTOF's efficacy in predicting optimal parameters and enhancing MRP. The predicted ion extraction delays for bradykinin fragment, P14R polypeptide, and insulin chain B ions were within 5% of the values observed through long‐term optimization. The observed MRP of those ions ranged from 2800 to 4500. Results show that the method and software are highly advantageous for fast and precise measurements.
Large angular correction of arithmetic coronal alignment is associated with residual lateral laxity after total knee arthroplasty in varus knees for Japanese patients
Authors: Itou Junya , Kuwashima Umito , Itoh Masafumi , Okazaki Ken 
Published: August 2024

AbstractPurposeOne of the most common types of coronal plane alignment of the knee (CPAK) is type I, which is characterised by varus alignment and apex distal joint line obliquity. The purpose of this study was to evaluate the association of changes in arithmetic hip–knee–ankle angle (aHKA) with both postoperative joint laxity and patient‐reported outcome measures (PROMs) in patients with CPAK type I following mechanical alignment (MA) total knee arthroplasty (TKA).MethodsOf 111 consecutive knees in 92 patients with osteoarthritis who underwent primary TKA, 80 knees (72.0%) with CPAK type I phenotype preoperatively were evaluated. All TKAs were performed to achieve neutral MA by a medial stabilising gap balancing technique. Pre‐ to postoperative change in aHKA was defined as ΔaHKA. The 80 CPAK type I knees were divided into a larger ΔaHKA group (>7°) and a smaller ΔaHKA group (≤7°). PROMs, including the Knee Society Score and Forgotten Joint Score‐12, were assessed before and 2 years after surgery. Pre‐ and postoperative joint laxity was assessed using a Telos arthrometer.ResultsTwenty‐two knees showed a larger ΔaHKA, and postoperative lateral joint laxity in varus stress was significantly greater in these patients than in those with a smaller ΔaHKA (6.8° vs. 4.5°, p = 0.006). There were no significant differences between the groups in PROMs (p = n.s.).ConclusionsPostoperative lateral laxity was associated with larger aHKA changes than smaller aHKA changes in CPAK type I knees after TKA. However, no statistically significant differences in PROMs were found according to the amount of change in aHKA.Level of EvidenceLevel III.
Novel co‐delivery of oridonin and docetaxel nanoliposome for an enhanced antitumor effect on esophageal cancer
Authors: Chen Xi , Mao Hengyu , Peng Feng , Fan Jiang , Yang Fu 
Published: August 2024

AbstractIntroductionEsophageal cancer is one of the major cancers in China. Most patients with esophageal cancer are diagnosed at an advanced stage, and the 5 year survival rate is discouraging. Combined chemotherapy is a common method for the treatment of esophageal cancer.MethodsIn this study, distearoyl phosphatidyl ethanolamine polyethylene glycol 2000 (DSPE‐PEG2000) nanoliposomes (NLPs) encapsulating the anticancer drugs docetaxel (DOX) and oridonin (ORD) were prepared, and their ability to enhance the release of anticancer drugs was determined. The NLP system was characterized by transmission electron microscopy, particle size and encapsulation efficiency. In addition, the release characteristics and pharmacodynamics of these drugs were also studied in detail.ResultsWhen the DOX/ORD ratio was 2:1, the higher proportion of DOX led to a stronger synergy effect. DOX/ORD NLPs were prepared by the high‐pressure homogenization method and had a uniform spherical morphology. The mean particle size and polydispersity index were determined to be 246.4 and 0.163, respectively. The stability results showed that no significant change was observed in particle size, zeta potential, Encapsulation efficiency and dynamic light scattering for DOX/ORD NLPs during the observation period. The results of in vitro release illustrated that the acidic environment of tumor might be beneficial to drug release. The three‐dimensional tumorsphere showed that DOX/ORD NLPs can reach the interior of tumor spheres, which destroys the structure of cells, resulting in irregular spherical tumor spheres. The in vivo study results indicated that DOX/ORD NLPs had an obvious targeting effect on subcutaneous tumors and have the potential to actively deliver drugs to tumor tissues. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining was used to detect apoptosis. The results showed that DOX/ORD NLP treatment could significantly induce apoptosis and inhibit tumor growth.ConclusionThe DOX/ORD NLPs prepared in this study can enhance the anti‐tumor activity, and are expected to be a promising co‐delivery platform for the treatment of esophageal cancer.
Epidemiological characteristics and serological survey of mumps 15 years after MMR vaccine was included in the immunization program
Authors: Gong Xiaoying , Fang Quanjun , Zheng Wangfeng , Lai Shiming , Xu Wenjie , Yin Zhiying 
Published: August 2024

AbstractMumps is a vaccine‐preventable acute viral infectious disease. To understand the incidence of mumps and population immunity in Quzhou City after measles mumps rubella vaccine (MMR) was included in the immunization program, we analyzed the epidemiological characteristics of mumps cases from 2009 to 2023 and a cross‐sectional serosurvey of IgG antibodies to mumps conducted in 2024. We found that 15 years after the MMR vaccine was included in the immunization program, the incidence of mumps was significantly reduced in all populations, but the incidence remained highest in vaccinated children aged 0–12 years. Vaccine escape may explain the high incidence of mumps in highly vaccinated populations. Updating vaccines or developing a new vaccine that targets multiple viral genotypes may be necessary to improve the effectiveness of the vaccine against infection and fully control infections and outbreaks. The positive rate and concentration of mumps IgG antibody were inconsistent with the incidence data. mumps IgG antibody is not an ideal substitute for immunity and cannot be used to accurately predict whether a target population is susceptible or protected. Natural infections may provide longer‐lasting immunity than vaccination.
Flow Injection Analysis With UV Detection Versus Raman Spectroscopy for the Quantitative Analysis of Remdesivir
Authors: Berge Marion , Siboni Jonhatan , Mequinion Carole , Caudron Eric , Lê Laetitia 
Published: August 2024

ABSTRACTThe quality and the security of preparations in hospital centres are essential to guarantee the patient's safety. The development of fast and efficient analytical methods is required to control the finished product before use. In this context, the study aimed to compare the performance and interchangeability of two spectral analytical methods: the flow injection analysis (FIA) with UV detection and the Raman spectroscopy for the quality control of preparation before use to quantify the remdesivir as a SARS‐CoV‐2 drug. A quantitative study of remdesivir was performed using clinically relevant concentration solutions ranging from 0.25 to 1.625 mg.mL−1 in 0.9% NaCl. Samples were analysed by FIA‐UV at 245 nm and by a handheld Raman spectroscopy at 785 nm. Quantitative models were developed using a calibration set (n = 45 samples) and optimized using a validation set (n = 27). An external validation test set (n = 58) was used to compare the two methods by a Bland–Altman plot. Partial least square regression was used to analyse Raman spectra, while univariate analysis was performed at 245 nm for FIA‐UV. The regression coefficient was higher than 0.990 for both methods, and the root mean square error of prediction was 0.031 mg.mL−1 for Raman spectroscopy. The Bland–Altman plot confirmed the interchangeability of the two methods and the potential of Raman spectroscopy to control remdesivir during clinical preparation in the hospital.
The Individual Participant Data Integrity Tool for assessing the integrity of randomised trials
Authors: Hunter Kylie E. , Aberoumand Mason , Libesman Sol , Sotiropoulos James X. , Williams Jonathan G. , Aagerup Jannik , Wang Rui , Mol Ben W. , Li Wentao , Barba Angie , Shrestha Nipun , Webster Angela C. , Seidler Anna Lene 
Published: August 2024

AbstractIncreasing concerns about the trustworthiness of research have prompted calls to scrutinise studies' Individual Participant Data (IPD), but guidance on how to do this was lacking. To address this, we developed the IPD Integrity Tool to screen randomised controlled trials (RCTs) for integrity issues. Development of the tool involved a literature review, consultation with an expert advisory group, piloting on two IPD meta‐analyses (including 73 trials with IPD), preliminary validation on 13 datasets with and without known integrity issues, and evaluation to inform iterative refinements. The IPD Integrity Tool comprises 31 items (13 study‐level, 18 IPD‐specific). IPD‐specific items are automated where possible, and are grouped into eight domains, including unusual data patterns, baseline characteristics, correlations, date violations, patterns of allocation, internal and external inconsistencies, and plausibility of data. Users rate each item as having either no issues, some/minor issue(s), or many/major issue(s) according to decision rules, and justification for each rating is recorded. Overall, the tool guides decision‐making by determining whether a trial has no concerns, some concerns requiring further information, or major concerns warranting exclusion from evidence synthesis or publication. In our preliminary validation checks, the tool accurately identified all five studies with known integrity issues. The IPD Integrity Tool enables users to assess the integrity of RCTs via examination of IPD. The tool may be applied by evidence synthesists, editors and others to determine whether an RCT should be considered sufficiently trustworthy to contribute to the evidence base that informs policy and practice.
Effects of high temperature on grain quality and enzyme activity in heat‐sensitive versus heat‐tolerant rice cultivars
Authors: Zhou Rong , Hu Qijuan , Meng Xiangfeng , Zhang Yue , Shuai Xingyang , Gu Yangfan , Li Yueyu , Chen Moxian , Wang Baohua , Cao Yunying 
Published: August 2024

AbstractBACKGROUNDHigh‐temperature (HT) stress significantly affects the quality of rice (Oryza sativa L.), although the underlying the mechanism remains unknown. Therefore, in the present study, we assessed protein components, amino acids, mineral element levels, starch biosynthesis enzyme activity and gene expression of two heat‐sensitive and two heat‐tolerant genotypes under HT treatment during early (from 1 to 10 days, T1) and mid‐filling (from 11 to 20 days, T2) after anthesis.RESULTSExcept for one cultivar, most rice varieties exhibited increased levels of amylose, chalky degree and protein content, along with elevated cracked grains and pasting temperatures and, consequently, suppressed amino acid levels under HT stress. HT treatment also increased protein components, macro‐ (Mg, K, P and S) and microelements (Cu, Zn, and Mo) in the rice flour. Both HT treatments reduced the activity of ADP‐glucose pyrophosphate, ground‐bound starch synthase, as well as the relative ratio of amylose to total starch, at the same time increasing starch branch enzyme activity. The expression levels of OsAGPL2, OsSSS1 and OsSBE1 in all varieties exhibited the same trends as enzyme activity under HT treatment.CONCLUSIONHigh temperatures negatively affected rice quality during grain filling, which is related to heat tolerance and grain shape. Altered enzymatic activity is crucial to compensate for the lowered enzyme quality under heat stress. © 2024 Society of Chemical Industry.
Multiclass and multi‐residue determination of pesticides and antibiotics in sediment from an aquacultural environment based on modified dispersive solid‐phase extraction
Authors: Qian Zhuozhen , Tang Shuifen , Liu Zhiyu , Luo Fangfang , Chen Yanting , Wei Shaohong 
Published: August 2024

A quick, easy, cheap, effective, rugged, and safe method was developed for the multi‐residue analysis of pesticides and antibiotics in aquaculture sediment using high‐performance liquid chromatography‐tandem mass spectrometry (HPLC‐MS/MS). The developed method is based on ultrasonic extraction with acetonitrile and phosphate buffer, salting with sodium chloride, and cleaning with dispersive solid‐phase extraction adsorbent using primary secondary amine, C18, and graphitized carbon black, followed by HPLC‐MS/MS detection. We optimized different extraction methods and the ratio of the cleanup adsorbents to achieve good recoveries at three spiking levels that ranged from 60.4% to 114% with a relative standard deviation below 15% (n = 6). For all analytes, except for flufenoxuron, the limits of quantification were between 1 and 5 µg/kg (dry weight). The validated method was successfully applied to real samples collected from 20 aquacultural ponds, confirming the feasibility of the proposed method. The concentrations of the target analytes in the sediments (dry weight) were in the ranges of 2.2–35.0 µg/kg for sulfonamides, 0–409.1 µg/kg for quinolones, 0–6.56 µg/kg for macrolides, and 0–4.9 µg/kg for pesticides. Moreover, the co‐occurrence of pesticides and antibiotics may potentially pose a high risk to sediment‐dwelling organisms in nine out of the 20 investigated locations.
The association between posttraumatic stress disorder symptom severity and distress tolerance in traumatic stress treatment
Authors: Byllesby Brianna M. , Palmieri Patrick A. 
Published: August 2024

AbstractDistress tolerance, or the perceived ability to tolerate negative emotional states, is often associated with posttraumatic stress disorder (PTSD) such that higher distress tolerance is generally associated with less severe PTSD symptom levels. As distress tolerance is often considered a risk and maintenance factor in distress disorders, examining the association between changes in distress tolerance and changes in PTSD symptoms may have clinical relevance. The present study examined the associations between PTSD symptom severity and distress tolerance across three assessment points over 12 weeks among 212 patients receiving outpatient psychotherapy services. Using random‐intercept cross‐lagged panel modeling (RI‐CLPM), concurrent and prospective associations between PTSD and distress tolerance were examined. PTSD symptoms at Time 1 and Time 2 significantly predicted distress tolerance at Time 2, β = −.296, and Time 3, β = −.395, respectively. Distress tolerance did not predict subsequent PTSD symptom severity. Exploratory analyses examined distress tolerance and four PTSD symptom clusters over time. Patterns of results differed across clusters, though it was consistent that only PTSD symptom clusters predicted subsequent distress tolerance and not vice versa. The results support the interrelationship of changes in psychopathology and emotional distress tolerance and indicate that distress tolerance may be an important factor in symptom remission during PTSD treatment.