bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis, Clinical Manifestations and Treatment of Lyme Disease
Authors: Jakubowska Katarzyna , Janocha Aleksandra , Jerzak Aneta , Ziemba Paweł 
Published: July 2024

Introduction and purpose
Lyme disease was identified in the 1970s. It is an anthropozoonosis caused by spirochetes from the Borrelia family. This disease is the most common one caused by pathogens transmitted by ticks. It can manifest in various ways and typically progresses through three phases, each of which can present characteristic symptoms of infection. However, it often progresses asymptomatically. Antibiotics are widely used in the treatment of various forms of Lyme disease and demonstrate satisfactory efficacy. However, the most important aspect is the prevention of infections through personal protection against exposure. The aim of the article is to summarize information on Lyme disease, its risk factors, diagnosis, clinical manifestations, and treatment.

Materials and methods
The literature available in the PubMed database is searched using terms such as Lyme borreliosis and Lyme disease.

Results
Lyme disease is a moderately understood condition. Its risk factors have been studied, allowing us to identify those particularly at risk. However, despite this, the condition often presents diagnostic challenges, requiring considerable experience from clinicians. The disease can manifest in various ways, and antibiotics are an effective therapy in most cases. Despite numerous scientific studies on Lyme disease, not all pathophysiological mechanisms have been elucidated. Additionally, there is an ongoing debate regarding the validity of post-treatment Lyme disease syndrome (PTLDS).

Conclusions
Research on Lyme disease continues to provide new information, from diagnostics and clinical manifestations to treatment. Knowledge about infections caused by genospecies of the Borrelia family is extensive. However, there are still areas that are less well understood.
Prognostic factors of early recurrence after complete cytoreductive surgery and hyperthermic intraperitoneal chemotherapy
Authors: Chen Chao-Yu , Huang Tzu-Hao , Lee Li-Wen , Lung Jrhau , Ou Yu-Che , Hung Chien-Hui , Chuang Huei-Chieh , Chen Min-Chi , Wang Ting-Yao 
Published: July 2024

BACKGROUND
Although cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) offer the potential for long-term survival in peritoneal carcinomatosis, outcomes following CRS/HIPEC vary significantly.
AIM
To identify the clinical factors associated with progression-free survival (PFS) after complete CRS/HIPEC in patients with colorectal/high-grade appendiceal, ovarian, and gastric cancers.
METHODS
We retrospectively evaluated the risk of recurrence within 1 year after CRS/HIPEC and its impact on overall survival (OS) in patients recruited between 2015 and 2020. Logistic regression models were used to assess the prognostic factors for the risk of recurrence within 1 year. Kaplan–Meier survival curves and Cox proportional hazards models were used to evaluate the association between recurrence and OS.
RESULTS
Of the 80 enrolled patients, 39 had an unfavorable PFS (< 1 year) and 41 had a favorable PFS (≥ 1 year). Simple logistic models revealed that the patients with a completeness of cytoreduction score of 0 (CC-0) or length of CRS ≤ 6 h had a favorable PFS [odds ratio (OR) = 0.141, P = 0.004; and OR = 0.361, P = 0.027, respectively]. In multiple logistic regression, achieving CC-0 was the strongest prognostic factor for a favorable PFS (OR = 0.131, P = 0.005). A peritoneal cancer index score > 12 was associated with a lower rate of achieving CC-0 (P = 0.027). The favorable PFS group had a significantly longer OS (median 81.7 mo vs 17.0 mo, P < 0.001).
CONCLUSION
Achieving CC-0 was associated with a lower early recurrence rate and improved long-term survival. This study underscores the importance of selecting appropriate candidates for CRS/HIPEC to manage peritoneal carcinomatosis.
Effect of sequential nursing care combined with communication intervention on visual recovery and pain after cataract ultrasound emulsification
Authors: Wang Jing-Cao , Zhang Qing , Yu Man-Rong , Yang Yun-Xia , Jiang Hui-Min 
Published: July 2024

BACKGROUND
Cataracts are a common ophthalmic disease and postoperative vision recovery is crucial to patient quality of life. Rational and efficient care models play an important role in promoting vision recovery.
AIM
To evaluate the clinical effectiveness of procedural nursing care combined with communication intervention in vision recovery after cataract ultrasound emulsification.
METHODS
A randomized controlled study was conducted on 100 patients with cataracts who underwent ultrasound emulsification surgery. They were randomly assigned to an experimental group or a control group. The experimental group received procedural nursing combined with Connect, Introduce, Communicate, Ask, Respond, Exit (CICARE) communication intervention, whereas the control group received conventional nursing. The effectiveness of the nursing model was assessed by comparing differences in vision recovery, pain scores, and mental health status between the two groups.
RESULTS
It was found that over time the visual acuity of patients in both groups gradually recovered and patients in the experimental group had lower pain scores and superior mental health status than the control group (P < 0.05).
CONCLUSION
Procedural nursing combined with CICARE communication intervention has positive effects on vision recovery in patients after cataract ultrasound emulsification.
Tuberculous peritonitis complicated by an intraperitoneal tuberculous abscess: A case report
Authors: Liu Wei-Peng , Ma Feng-Zhen , Zhao Zhou , Li Zong-Rui , Hu Bao-Guang , Yang Tao 
Published: July 2024

BACKGROUND
Tuberculous peritonitis (TBP) is a chronic, diffuse inflammation of the peritoneum caused by Mycobacterium tuberculosis . The route of infection can be by direct spread of intraperitoneal tuberculosis (TB) or by hematogenous dissemination. The former is more common, such as intestinal TB, mesenteric lymphatic TB, fallopian tube TB, etc. , and can be the direct primary lesion of the disease.
CASE SUMMARY
We present an older male patient with TBP complicated by an abdominal mass. The patient's preoperative symptoms, signs and imaging data suggested a possible abdominal tumor. After surgical treatment, the patient's primary diagnosis of TBP complicating an intraperitoneal tuberculous abscess was established by combining past medical history, postoperative pathology, and positive results of TB-related laboratory tests. The patient's symptoms were significantly reduced after surgical treatment, and he was discharged from the hospital with instructions to continue treatment at a TB specialist hospital and to undergo anti-TB treatment if necessary.
CONCLUSION
This case report analyses the management of TBP complicated by intraperitoneal tuberculous abscess and highlights the importance of early definitive diagnosis in the hope of improving the clinical management of this type of disease.
Acessibilidade geográfica de idosos aos cuidados primários de uma unidade de Estratégia Saúde da Família, Diamantina, MG
Authors: Fonseca Santos Delba , Alencar Mendes Victor Alexsander , Santos Cardoso Mateus Filipe , De Paula Barreiro Alves Camila 
Published: July 2024

Introdução: A qualidade de vida dos idosos está associada aos meios que facilitam seu acesso à saúde, entre eles a acessibilidade geográfica. Diante disso, o estudante de medicina dispõe de ferramentas que avaliam o território e suas barreiras físicas, elencando os impactos e promovendo melhor acesso aos serviços de saúde. Objetivo: Estudar o acesso geográfico de uma unidade de atenção primária à saúde, dentro da rede de atenção e os possíveis impactos na saúde do idoso. Materiais e métodos: O estudo foi realizado por meio de dados da Estratégia de Saúde da Família Centro na cidade de Diamantina-MG, como informações sobre o território e número de consultas. Ademais, dados construídos pelos autores a partir das ferramentas Google Maps e Planilhas do Google, como mapas, lista de serviços da rede de saúde e tabelas sobre tempo de locomoção/distância até os serviços. Resultados: Ao analisar a distribuição geográfica da ESF Centro, dividida em quatro áreas, é possível avaliar nas MA 01 e 02 uma melhor acessibilidade aos serviços de saúde por essa população, pois 94,87% das ruas com intervalo de distância de 0-400m da ESF, concentra-se nas MA 01 e 02. Outro dado relevante são os números de consultas, que do total realizadas na ESF Centro, em dias aleatórios, a participação dessas MA (01 e 02) representa 69,4% das consultas. Conclusão: Conclui-se que o fator distância e tempo de deslocamento até a unidade de saúde e outros serviços são índices que afetam o acesso à saúde pelos idosos.
Enhancing care in the initiation and management of insulin in older people with diabetes: A collaborative journey with older individuals and their caregivers using Experience-Based Co-Design
Authors: Langerman Chaya , Forbes Angus , Robert Glenn 
Published: July 2024

Introduction
Initiating insulin therapy in older individuals with type 2 diabetes (T2DM) poses unique challenges and requires a nuanced understanding of the age-related factors that impact safety and efficacy. This study employed Experience-Based Co-Design (EBCD) to enhance the insulin initiation and management experience for this population, emphasising a collaborative approach involving patients, caregivers, and healthcare professionals.

Aim
The primary aim of the research was to develop a tailored care pathway, utilising co-design and the Behaviour Change Wheel (BCW), which addressed issues specific to older adults on insulin therapy. The study sought to identify key challenges, propose practical interventions, and construct a logic model illustrating a pathway for enhanced insulin treatment experiences.

Methods
An adapted EBCD process was used which integrated the Medical Research Council (MRC) Framework and BCW. The study involved thematic synthesis, video interviews, and feedback focus groups with patients, caregivers, and healthcare professionals. The ’Crazy Eights’ brainstorming method, as part of the co-design workshop, generated practical solutions which informed subsequent logic model development.

Results
Focus group findings revealed distressing insulin initiation experiences, inconsistent dietary advice, and perceived disparities in care between type 1 and type 2 diabetes. The co-design workshop identified eight key challenges, leading to proposed interventions aligned with the BCW. The logic model illustrates a pathway for older individuals undergoing insulin treatment, emphasising behaviour change among patients, caregivers, and healthcare professionals.

Conclusion
The collaborative efforts of participants contributed valuable insights in terms of the unique educational and emotional needs of patients, the importance of care continuity and of improving access to specialist services. Findings from this study can be used to inform and enhance tailored support strategies for older adults with T2DM during their insulin transition and ongoing management.
Prognostic potential of integrated morphologic and metabolic parameters of pre-therapeutic [18F]FDG-PET/CT regarding progression-free survival (PFS) and overall survival (OS) in NSCLC-patients
Authors: Peters Helena A. , Weiss Daniel , Boschheidgen Matthias , Mamlins Eduards , Giesel Frederik L. , Fluegen Georg , Kirchner Julian , Antoch Gerald , Jannusch Kai 
Published: July 2024

Purpose
This study aimed to evaluate the prognostic potential of pre-therapeutic [18F]FDG-PET/CT variables regarding prediction of progression-free survival (PFS) and overall survival (OS) in NSCLC-patients.

Method
NSCLC-patients who underwent pre-therapeutic [18F]FDG-PET/CT were retrospectively analyzed. The following imaging features were collected from the primary tumor: tumor size, tumor density, central necrosis, spicules and SUVmax. For standardization, an indexSUVmax was calculated (SUVmax primary tumor/SUVmax liver). Descriptive statistics and correlations of survival time analyses for PFS and OS were calculated using the Kaplan-Meier method and Cox regression including a hazard ratio (HR). A value of p < 0.05 was set as statistically significant. The 95%-confidence intervals (CI) were calculated. The median follow-up time was 63 (IQR 27–106) months.

Results
This study included a total of 82 patients (25 women, 57 men; mean age: 66 ± 9 years). IndexSUVmax (PFS: HR = 1.0, CI: 1.0–1.1, p = 0.49; OS: HR = 1.0, CI: 0.9–1.2, p = 0.41), tumor size (PFS: HR = 1.0, CI: 0.9–1.0, p = 0.08; OS: HR = 1.0, CI: 0.9–1.0, p = 0.07), tumor density (PFS: HR = 0.9, CI: 0.6–1.4, p = 0.73; OS: HR = 0.3; CI: 0.1–1.1; p = 0.07), central necrosis (PFS: HR = 1.0, CI: 0.6–1.8, p = 0.98; OS: HR = 0.6, CI: 0.2–1.9, p = 0.40) and spicules (PFS: HR = 1.0, CI: 0.6–1.9, p = 0.91; OS: HR = 1.3, CI: 0.4–3.7, p = 0.65) did not significantly affect PFS and OS in the study population. An optimal threshold value for the indexSUVmax was determined by ROC analysis and Youden’s index. There was no significant difference in PFS with an indexSUVmax-threshold of 3.8 (13 vs. 27 months; p = 0.45) and in OS with an indexSUVmax-threshold of 4.0 (113 vs. 106 months; p = 0.40).

Conclusions
SUVmax and morphologic parameters from pre-therapeutic [18F]FDG-PET/CT were not able to predict PFS and OS in NSCLC-patients.
Anxiety and depression among hypertensive patients during the COVID-19 pandemic: A cross-sectional study from Kathmandu Metropolitan, Nepal
Authors: K. C. Dilasha , Kaphle Hari Prasad , Shrestha Durga , Neupane Nirmala 
Published: July 2024

Introduction
The outbreak of a global pandemic like COVID-19 has highlighted significant distress around mental health. The burden of mental health issues like anxiety and depression requires evidence-based intervention, especially in low-income settings like Nepal. The study aims to determine the prevalence of anxiety and depression and the factors associated with it among hypertensive patients.

Materials and methods
The quantitative cross-sectional study design was used for this study. The study was conducted among 374 samples from selected wards of Kathmandu Metropolitan using a convenience sampling technique. Face-to-face interviews were conducted using a structured interview schedule. A Chi-square test was used to identify the statistical significance between dependent and independent variables. Binary logistic regression analysis was performed to determine the factors associated with anxiety and depression.

Results
The prevalence of anxiety and depression among hypertensive patients during the COVID-19 pandemic was 27.8% and 24.3% respectively. According to the results of bivariate logistic regression analysis, smoking/tobacco consumption, staying in quarantine, positive COVID-19 test result, history of COVID-19 positive in the family, History of death due to COVID-19 in the family, visiting a hospital during the COVID-19 pandemic appeared as influencing factors of both anxiety and depression.

Conclusion
Our findings suggest that COVID-19 has a substantial effect on the mental health of hypertensive patients. This study highlights the need to develop early intervention and coping strategies among this population to minimize the negative impact of COVID-19 on their mental health and well-being.
Association between various physical activity domains and overall cancer risk, National Health and Nutrition Examination Survey (NHANES) 2007–2018
Authors: Lian Yanxue , Luo Pincheng 
Published: July 2024

Purpose
There are very few studies concurrently evaluating the association between multiple physical activity (PA) domains and cancer prevalence. Therefore, this study aims to fill this gap by investigating the link between multiple PA subdomains [occupational PA (OPA), transportation-related PA (TPA), leisure-time PA (LTPA), and total PA] and the likelihood of cancer.

Method
The data from National Health and Nutrition Examination Survey (NHANES) 2007–2008, 2009–2010, 2011–2012, 2013–2014, 2015–2016, and 2017–2018 were used in this study. Cancers are the primary outcome variable of interest in this study. PA was self- or proxy-reported using the Global Physical Activity Questionnaire (GPAQ). Multivariable logistic regression models were used, adjusted for covariates.

Results
The trend analysis revealed that the prevalence of cancer statistically decreased with the increase in total PA amount. The participants achieving twice the minimum recommended PA guidelines (≥300 minutes) for total PA were 32% [0.68 (0.54, 0.86)] less likely to have cancer. However, significant associations between three PA subdomains (OPA, TPA, and LTPA) and cancers were not found in this study.

Conclusion
There is no significant association between any of these three single PA subdomains and cancer prevalence other than total PA. Therefore, this study recommends clinical practice should prioritize promoting comprehensive PA that integrates OPA, TPA, and LTPA to achieve at least 150 minutes per week (i.e. per seven days) initially and progressing towards 300 minutes for optimal cancer prevention.
Waisenfürsorger (ὀρφανοεπιμεληταί) und Fohlenbezähmer (πωλοδαμασταί) im ptolemäischen Ägypten
Authors: Scheuble-Reiter Sandra 
Published: July 2024

Abstract
This article presents an unpublished Ptolemaic papyrus from the collection of the University of Trier which contains an official letter concerning a tax-collection. The papyrus is of special interest, firstly because of its unusual receipt form which requires further investigation, and secondly and primarily, however, because of its exceptional lexicography.
Il saluto conclusivo nelle lettere degli alti funzionari provinciali: ἐρρῶσθαι ... βούλομαι
Authors: Mascellari Roberto 
Published: July 2024

Abstract
By re-examining the letters of prefects and other officials, this article proposes to consider ἐρρῶσθαι ... βούλομαι as the standard epistolary farewell formula in Greek used by prefects from the early 2nd century CE to the mid-3rd century CE, while in the same period ἐρρῶσθαι ... εὔχομαι was avoided by prefects and commonly used by subordinate officials.
Metformin mitigates osteoarthritis progression by modulating the PI3K/AKT/mTOR signaling pathway and enhancing chondrocyte autophagy
Authors: Xu Tianjie , Liu Kainan , Fan Jiaxin , Jia Xiang , Guo Xiaoling , Zhao Xingwang , Cao Yanhua , Zhang Hui , Wang Qian 
Published: July 2024

Abstract
Osteoarthritis (OA) is a chronic degenerative disease characterized by overall joint tissue damage. Metformin (Met) has been shown to inhibit inflammatory reactions, though its potential protective mechanism on cartilage remains unclear. This study investigated Met’s potential to protect cartilage in an OA rat model. Various morphological experiments were conducted to assess changes in cartilage tissue morphology before and after Met treatment. Protein and mRNA levels of cartilage-specific genes were measured using western blot, immunohistochemical staining, and RT-qPCR. Additionally, protein levels of autophagy-related and mTOR pathway-related proteins were measured. The results indicate an imbalance in the synthesis and degradation metabolism of chondrocytes, downregulation of cellular autophagy, and activation of the PI3K/Akt/mTOR pathway after surgery. However, treatment with Met could upregulate the expression of synthetic metabolic factors, indicating its contribution to cartilage repair. Furthermore, analysis of autophagy and pathway protein levels indicated that Met effectively attenuated autophagic damage to osteoarthritic cartilage cells and abnormal activation of the PI3K/Akt/mTOR pathway. In conclusion, Met can inhibit the abnormal activation of the PI3K/AKT/mTOR signaling pathway in cartilage tissue, promote the restoration of cartilage cell autophagic function, improve the balance of cartilage cell synthesis and degradation metabolism, and thus exert a protective effect on rat joint cartilage.
Supply chain efficiency of red chilies in the production center of Sleman Indonesia based on performance measurement system
Authors: Susanawati Susanawati , Noviyanti Nadia 
Published: July 2024

Abstract
This study aims to describe the red chili supply chain in the production center of Sleman Regency and examine its efficiency using the performance measurement system (PMS). The period of secondary data from 2016 to 2020 in this study was employed on the grounds of time before and during the COVID-19 pandemic. It was based on Presidential Decree No. 11 of 2020 concerning the determination of the Coronavirus Disease 2019 Public Health Emergency in Indonesia on March 31, 2020, designating COVID-19 as a pandemic. The sampling for this study began in Pakem District and proceeded in phases to Purwobinangun Village. Moreover, 61 respondents were determined through snowball sampling from farmers to consumers in Sleman Regency. The red chili supply chain was evaluated descriptively, and its efficiency was analyzed using the PMS indicators, encompassing production cost, profit, return on investment (ROI), and transaction cost. The findings unveiled that the red chili supply chain consisted of five chains with six actors: (1) Farmers – Auction Market – Collecting Traders – Retailers – Consumers; (2) Farmers – Auction Market – Intermediaries – Collecting Traders – Retailers – Consumers; (3) Farmers – Intermediaries – Collecting Traders – Retailers – Consumers; (4) Farmers – Intermediaries – Retailers – Consumers; and (5) Farmers – Retailers – Consumers. Regarding the efficiency of the five supply chains, Chain 2 obtained the highest profit and ROI, while Chain 5 possessed the lowest production and transaction cost, making them the most efficient ones.
Load-Velocity Relationship in the Bulgarian Split-Squat Exercise
Authors: Rabal-Pelay Juan , Gutiérrez Héctor , Bascuas Pablo Jesús , Pareja-Blanco Fernando , Marco-Contreras Luis Alberto 
Published: July 2024

Abstract
Rabal-Pelay, J, Gutiérrez, H, Bascuas, P-J, Pareja-Blanco, F, and Marco-Contreras, LA. Load-velocity relationship in the Bulgarian split-squat exercise. J Strength Cond Res XX(X): 000–000, 2024—The objective of the current research was to analyze the load-velocity relationship in the Bulgarian split-squat (BSS) exercise and to compare these relationships between the dominant and nondominant legs. Twenty-one strength-trained men (age: 27.3 ± 7.3 years) performed a progressive loading test in the BSS exercise using a Smith machine for each leg. The protocol began with a load of 30 kg, incrementally adding 10 kg until the mean propulsive velocity (MPV) fell below 0.4 m·s−1. At that point, 5 kg increments were employed, with a final addition of 2.5 kg for the last estimated attempt one-repetition maximum (1RM). A total of 324 lifts were analyzed. Subjects exhibited a relative strength ratio of 1.23 ± 0.10, a 1RM of 91.3 ± 14.2 kg, and a mean range of motion of 44.7 ± 3.7 cm. Polynomial regression analysis showed a robust relationship with an R
2 value of 0.945 (ρ ≤ 0.001) between the relative load (%1RM) and MPV. Despite the differences in 1RM between the dominant and nondominant legs, there were no significant differences in MPV at the %1RM between both legs. These findings suggest that training intensity can be prescribed via the MPV during the BSS exercise. Moreover, the load-velocity relationship is stable between limbs despite the potential differences in absolute strength levels.