bluuebunny/crossref_metadata_2025_split huggingface dataset:
Magnetohydrodynamic, Thermal Radiation and Convective Boundary Effects of Free Convection Flow Past a Vertical Plate Embedded in a Porous Medium Saturated with a Nanofluid
Authors: Agha H. Ali , Bouaziz M. N. , Hanini S. 
Published: July 2015

AbstractA numerical analysis was performed to study the effects of combined magnetohydrodynamic and thermal radiation under convective boundary condition over a semi infinite vertical plate embedded in a non-Darcy porous medium. Coupled heat and mass transfer of free convective boundary layer with viscous nanofluid are considered. The model used for the nanofluid includes the effects of Brownian motion and thermophoresis mechanisms, while the Darcy-Forchheimer model is used for the porous medium. The governing partial differential equations are transformed into the ordinary differential equations using the similarity transformations. The accuracy of the method is observed by a comparison with other works reduced to a common case. Many results are tabulated and representative set is displayed graphically to illustrate the influence of the various parameters of interest on different profiles. Extensive numerical investigations show that the flow field, temperature, concentration and nanoparticle volume fraction shapes are significantly influenced by magnetic parameter, regular Lewis number, Brownian motion parameter, thermophoresis parameter, regular buoyancy ratio parameter and Biot number. Heat and mass transfer rates are significantly affected by the level of the applied magnetic field and the convective heat coefficient.
Effects of school meals with weekly fish servings on vitamin D status in Danish children: secondary outcomes from the OPUS (Optimal well-being, development and health for Danish children through a healthy New Nordic Diet) School Meal Study
Authors: Petersen Rikke A. , Damsgaard Camilla T. , Dalskov Stine-Mathilde , Sørensen Louise B. , Hjorth Mads Fiil , Andersen Rikke , Tetens Inge , Krarup Henrik , Ritz Christian , Astrup Arne , Michaelsen Kim F. , Mølgaard Christian 
Published: July 2015

AbstractChildren's vitamin D intake and status can be optimised to meet recommendations. We investigated if nutritionally balanced school meals with weekly fish servings affected serum 25-hydroxyvitamin D (25(OH)D) and markers related to bone in 8- to 11-year-old Danish children. We conducted an explorative secondary outcome analysis on data from 784 children from the OPUS School Meal Study, a cluster-randomised cross-over trial where children received school meals for 3 months and habitual lunch for 3 months. At baseline, and at the end of each dietary period, 25(OH)D, parathyroid hormone (PTH), osteocalcin (OC), insulin-like growth factor-1 (IGF-1), bone mineral content (BMC), bone area (BA), bone mineral density (BMD), dietary intake and physical activity were assessed. School meals increased vitamin D intake by 0·9 (95 % CI 0·7, 1·1) μg/d. No consistent effects were found on 25(OH)D, BMC, BA, BMD, IGF-1 or OC. However, season-modified effects were observed with 25(OH)D, i.e. children completing the school meal period in January/February had higher 25(OH)D status (5·5 (95 % CI 1·8, 9·2) nmol/l; P = 0·004) than children completing the control period in these months. A similar tendency was indicated in November/December (4·1 (95 % CI –0·12, 8·3) nmol/l; P = 0·057). However, the effect was opposite in March/April (–4·0 (95 % CI –7·0, –0·9) nmol/l; P = 0·010), and no difference was found in May/June (P = 0·214). Unexpectedly, the school meals slightly increased PTH (0·18 (95 % CI 0·07, 0·29) pmol/l) compared with habitual lunch. Small increases in dietary vitamin D might hold potential to mitigate the winter nadir in Danish children's 25(OH)D status while higher increases appear necessary to affect status throughout the year. More trials on effects of vitamin D intake from natural foods are needed.
Downregulation of N-terminal acetylation triggers ABA-mediated drought responses in Arabidopsis
Authors: Linster Eric , Stephan Iwona , Bienvenut Willy V. , Maple-Grødem Jodi , Myklebust Line M. , Huber Monika , Reichelt Michael , Sticht Carsten , Geir Møller Simon , Meinnel Thierry , Arnesen Thomas , Giglione Carmela , Hell Rüdiger , Wirtz Markus 
Published: July 2015

AbstractN-terminal acetylation (NTA) catalysed by N-terminal acetyltransferases (Nats) is among the most common protein modifications in eukaryotes, but its significance is still enigmatic. Here we characterize the plant NatA complex and reveal evolutionary conservation of NatA biochemical properties in higher eukaryotes and uncover specific and essential functions of NatA for development, biosynthetic pathways and stress responses in plants. We show that NTA decreases significantly after drought stress, and NatA abundance is rapidly downregulated by the phytohormone abscisic acid. Accordingly, transgenic downregulation of NatA induces the drought stress response and results in strikingly drought resistant plants. Thus, we propose that NTA by the NatA complex acts as a cellular surveillance mechanism during stress and that imprinting of the proteome by NatA is an important switch for the control of metabolism, development and cellular stress responses downstream of abscisic acid.
Conditional rotation of two strongly coupled semiconductor charge qubits
Authors: Li Hai-Ou , Cao Gang , Yu Guo-Dong , Xiao Ming , Guo Guang-Can , Jiang Hong-Wen , Guo Guo-Ping 
Published: July 2015

AbstractUniversal multiple-qubit gates can be implemented by a set of universal single-qubit gates and any one kind of entangling two-qubit gate, such as a controlled-NOT gate. For semiconductor quantum dot qubits, two-qubit gate operations have so far only been demonstrated in individual electron spin-based quantum dot systems. Here we demonstrate the conditional rotation of two capacitively coupled charge qubits, each consisting of an electron confined in a GaAs/AlGaAs double quantum dot. Owing to the strong inter-qubit coupling strength, gate operations with a clock speed up to 6 GHz have been realized. A truth table measurement for controlled-NOT operation shows comparable fidelities to that of spin-based two-qubit gates, although phase coherence is not explicitly measured. Our results suggest that semiconductor charge qubits have a considerable potential for scalable quantum computing and may stimulate the use of long-range Coulomb interaction for coherent quantum control in other devices.
Quenching of dynamic nuclear polarization by spin–orbit coupling in GaAs quantum dots
Authors: Nichol John M. , Harvey Shannon P. , Shulman Michael D. , Pal Arijeet , Umansky Vladimir , Rashba Emmanuel I. , Halperin Bertrand I. , Yacoby Amir 
Published: July 2015

AbstractThe central-spin problem is a widely studied model of quantum decoherence. Dynamic nuclear polarization occurs in central-spin systems when electronic angular momentum is transferred to nuclear spins and is exploited in quantum information processing for coherent spin manipulation. However, the mechanisms limiting this process remain only partially understood. Here we show that spin–orbit coupling can quench dynamic nuclear polarization in a GaAs quantum dot, because spin conservation is violated in the electron–nuclear system, despite weak spin–orbit coupling in GaAs. Using Landau–Zener sweeps to measure static and dynamic properties of the electron spin–flip probability, we observe that the size of the spin–orbit and hyperfine interactions depends on the magnitude and direction of applied magnetic field. We find that dynamic nuclear polarization is quenched when the spin–orbit contribution exceeds the hyperfine, in agreement with a theoretical model. Our results shed light on the surprisingly strong effect of spin–orbit coupling in central-spin systems.
Giant narrowband twin-beam generation along the pump-energy propagation direction
Authors: Pérez Angela M. , Spasibko Kirill Yu , Sharapova Polina R. , Tikhonova Olga V. , Leuchs Gerd , Chekhova Maria V. 
Published: July 2015

AbstractWalk-off effects, originating from the difference between the group and phase velocities, limit the efficiency of nonlinear optical interactions. While transverse walk-off can be eliminated by proper medium engineering, longitudinal walk-off is harder to avoid. In particular, ultrafast twin-beam generation via pulsed parametric down-conversion and four-wave mixing is only possible in short crystals or fibres. Here we show that in high-gain parametric down-conversion, one can overcome the destructive role of both effects and even turn them into useful tools for shaping the emission. In our experiment, one of the twin beams is emitted along the pump Poynting vector or its group velocity matches that of the pump. The result is markedly enhanced generation of both twin beams, with the simultaneous narrowing of angular and frequency spectrum. The effect will enable efficient generation of ultrafast twin photons and beams in cavities, waveguides and whispering-gallery mode resonators.
Long-life Li/polysulphide batteries with high sulphur loading enabled by lightweight three-dimensional nitrogen/sulphur-codoped graphene sponge
Authors: Zhou Guangmin , Paek Eunsu , Hwang Gyeong S. , Manthiram Arumugam 
Published: July 2015

AbstractLithium–sulphur batteries with a high theoretical energy density are regarded as promising energy storage devices for electric vehicles and large-scale electricity storage. However, the low active material utilization, low sulphur loading and poor cycling stability restrict their practical applications. Herein, we present an effective strategy to obtain Li/polysulphide batteries with high-energy density and long-cyclic life using three-dimensional nitrogen/sulphur codoped graphene sponge electrodes. The nitrogen/sulphur codoped graphene sponge electrode provides enough space for a high sulphur loading, facilitates fast charge transfer and better immobilization of polysulphide ions. The hetero-doped nitrogen/sulphur sites are demonstrated to show strong binding energy and be capable of anchoring polysulphides based on first-principles calculations. As a result, a high specific capacity of 1,200 mAh g−1 at 0.2C rate, a high-rate capacity of 430 mAh g−1 at 2C rate and excellent cycling stability for 500 cycles with ∼0.078% capacity decay per cycle are achieved.
An autoinhibitory mechanism modulates MAVS activity in antiviral innate immune response
Authors: Shi Yuheng , Yuan Bofeng , Qi Nan , Zhu Wenting , Su Jingru , Li Xiaoyan , Qi Peipei , Zhang Dan , Hou Fajian 
Published: July 2015

AbstractIn response to virus infection, RIG-I senses viral RNA and activates the adaptor protein MAVS, which then forms prion-like filaments and stimulates a specific signalling pathway leading to type I interferon production to restrict virus proliferation. However, the mechanisms by which MAVS activity is regulated remain elusive. Here we identify distinct regions of MAVS responsible for activation of transcription factors interferon regulatory factor 3 (IRF3) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB). These IRF3- and NF-κB-stimulating regions recruit preferential TNF receptor-associated factors (TRAFs) for downstream signalling. Strikingly, these regions’ activities are inhibited by their respective adjacent regions in quiescent MAVS. Our data thus show that an autoinhibitory mechanism modulates MAVS activity in unstimulated cells and, on viral infection, individual regions of MAVS are released following MAVS filament formation to activate antiviral signalling cascades.
Accelerated Sorption Diffusion for Cu(II) Retention by Anchorage of Nano-zirconium Dioxide onto Highly charged Polystyrene Material
Authors: Zhang Qingrui , Du Qing , Jiao Tifeng , Teng Jie , Sun Qina , Peng Qiuming , Chen Xinqing , Gao Faming 
Published: July 2015

AbstractThe development of nanocomposite with strong adsorption ability exhibits great potential applications for environmental remediation. However, the pore blocking in preparation frequently constrains sorption diffusion, resulting in low utilization efficiency. Here we synthesized a new nano-ZrO2/Polystyrene (NZO-PS) material tailored with a specific fixed SO3-Na group to enhance Cu(II) removal. The NZO-PS exhibits efficient Cu(II) sequestration in a wide pH range (3.0–6.5) and preferential sorption performances. The efficient kinetic behavior and column applicability suggest the blocked pore channel is not a matter when presence of negatively charged moiety, which accelerates Cu(II) sorption diffusion and enrichment toward target active site. Moreover, the exhausted NZO-PS can be readily regenerated through HCl-NaCl binary solution. The preparation route can be extended to synthesize other functional composited materials. Simultaneously, the characteristics of simplicity, high-yield and regeneration provide some promising industrial merits.
Characterization of species-specific genes regulated by E2-2 in human plasmacytoid dendritic cells
Authors: Cheng Menglan , Zhang Xuyuan , Yu Haisheng , Du Peishuang , Plumas Joël , Chaperot Laurance , Su Lishan , Zhang Liguo 
Published: July 2015

AbstractDendritic cells (DCs) are sentinels of the immune system and comprise two distinct subsets: conventional DCs (cDCs) and plasmacytoid DCs (pDCs). Human pDCs are distinguished from mouse pDCs phenotypically and functionally. Basic helix-loop-helix protein E2-2 is defined as an essential transcription factor for mouse pDC development, cell fate maintenance and gene programe. It is unknown whether E2-2 regulation contributes to this species-specific difference. Here we investigated the function of E2-2 in human pDCs and screened human-specific genes regulated by E2-2. Reduced E2-2 expression in human pDC cell line GEN2.2 resulted in diminished IFN-α production in response to CpG but elevated antigen presentation capacity. Gene expression profiling showed that E2-2 silence down-regulated pDC signature genes but up-regulated cDC signature genes. Thirty human-specific genes regulated by E2-2 knockdown were identified. Among these genes, we confirmed that expression of Siglec-6 was inhibited by E2-2. Further more, Siglec-6 was expressed at a higher level on a human pDC subset with drastically lower expression of E2-2. Collectively, these results highlight that E2-2 modulates pDC function in a species-specific manner, which may provide insights for pDC development and functions.
Identification of ULK1 as a novel biomarker involved in miR-4487 and miR-595 regulation in neuroblastoma SH-SY5Y cell autophagy
Authors: Chen Yi , Wang Shuya , Zhang Lan , Xie Tao , Song Sicheng , Huang Jian , Zhang Yonghui , Ouyang Liang , Liu Bo 
Published: July 2015

AbstractAutophagy, referring to an evolutionarily conserved, multi-step lysosomal degradation process, has been well-known to be initiated by Unc-51 like kinase 1 (ULK1) with some links to Parkinson’s disease (PD). MicroRNAs (miRNAs), small and non-coding endogenous RNAs 22 ~ 24 nucleotides (nt) in length, have been demonstrated to play an essential role for modulating autophagy. Recently, the relationships between miRNAs and autophagy have been widely reported in PD; however, how microRNAs regulate autophagy still remains in its infancy. Thus, in this study, we computationally constructed the ULK1-regulated autophagic kinase subnetwork in PD and further identified ULK1 able to negatively regulate p70S6K in starvation-induced autophagy of neuroblastoma SH-SY5Y cells. Combination of in silico prediction and microarray analyses, we identified that miR-4487 and miR-595 could target ULK1 and experimentally verified they could negatively or positively regulate ULK1-mediated autophagy. In conclusion, these results may uncover the novel ULK1-p70S6K autophagic pathway, as well as miR-4487 and miR-595 as new ULK1 target miRNAs. Thus, these findings would provide a clue to explore ULK1 and its target miRNAs as potential biomarkers in the future PD therapy.
The making of a branching annelid: an analysis of complete mitochondrial genome and ribosomal data of Ramisyllis multicaudata
Authors: Aguado M. Teresa , Glasby Christopher J. , Schroeder Paul C. , Weigert Anne , Bleidorn Christoph 
Published: July 2015

AbstractRamisyllis multicaudatais a member of Syllidae (Annelida, Errantia, Phyllodocida) with a remarkable branching body plan. Using a next-generation sequencing approach, the complete mitochondrial genomes ofR. multicaudataandTrypanobiasp. are sequenced and analysed, representing the first ones from Syllidae. The gene order in these two syllids does not follow the order proposed as the putative ground pattern in Errantia. The phylogenetic relationships ofR. multicaudataare discerned using a phylogenetic approach with the nuclear18Sand the mitochondrial16Sandcox1genes.Ramisyllis multicaudatais the sister group of a clade containingTrypanobiaspecies. Both genera,RamisyllisandTrypanobia, together withParahaplosyllis,Trypanosyllis, Eurysyllis,andXenosyllisare located in a long branched clade. The long branches are explained by an accelerated mutational rate in the18SrRNA gene. Using a phylogenetic backbone, we propose a scenario in which the postembryonic addition of segments that occurs in most syllids, their huge diversity of reproductive modes and their ability to regenerate lost parts, in combination, have provided an evolutionary basis to develop a new branching body pattern as realised inRamisyllis.
Pockels effect of silicate glass-ceramics: Observation of optical modulation in Mach–Zehnder system
Authors: Yamaoka Kazuki , Takahashi Yoshihiro , Yamazaki Yoshiki , Terakado Nobuaki , Miyazaki Takamichi , Fujiwara Takumi 
Published: July 2015

AbstractSilicate glass has been used for long time because of its advantages from material’s viewpoint. In this paper, we report the observation of Pockels effect by Mach–Zehnder interferometer in polycrystalline ceramics made from a ternary silicate glass via crystallization due to heat-treatment, i.e., glass-ceramics. Since the silicate system is employed as the precursor, merits of glass material are fully utilized to fabricate the optical device component, in addition to that of functional crystalline material, leading us to provide an electro-optic device, which is introducible into glass-fiber network.
MAD1L1 Arg558His and MAD2L1 Leu84Met interaction with smoking increase the risk of colorectal cancer
Authors: Zhong Rong , Chen Xiaohua , Chen Xueqin , Zhu Beibei , Lou Jiao , Li Jiaoyuan , Shen Na , Yang Yang , Gong Yajie , Zhu Ying , Yuan Jing , Xia Xiaoping , Miao Xiaoping 
Published: July 2015

AbstractThe spindle assembly checkpoint (SAC) has been established as an important mechanism of driving aneuploidy, which occurs at a high frequency in the colorectal tumorigenesis. Two important components of SAC are MAD1L1 and MAD2L1, which function together in an interactive manner to initiate the checkpoint signal. We hypothesize that genetic variants in the binding domains of MAD1L1 and MAD2L1 may modulate protein structures and eventually contribute to CRC susceptibility. A case-control study including 710 CRC cases and 735 controls was performed to examine MAD1L1 Arg558His and MAD2L1 Leu84Met’s conferring susceptibility to CRC. Cytokinesis-block micronucleus cytome assays were applied to assess the effect of two functional variants on chromosomal instability (CIN). Significant associations with CRC risk were observed for MAD1L1 Arg558His (OR = 1.38,95% CI: 1.09–1.75) and MAD2L1 Leu84Met in a dominant model (OR = 1.48,95% CI: 1.09–2.01). Moreover, significant multiplicative gene-smoking interactions were found in MAD1L1 Arg558His (P = 0.019) and MAD2L184 Leu/Met (P = 0.016) to enhance CRC risk. Additionally, the frequencies of lymphocytic micro-nucleated binucleated cells for MAD1L1 Arg558His polymorphism were significantly different in the exposed group (P = 0.013), but not in the control group. The study emphasized that MAD1L1 Arg558His and MAD2L1 Leu84Met can significantly interact with smoking to enhance CRC risk and the genetic effects of MAD1L1Arg558His on CIN need to be further clarified in follow-up studies.
Handedness Dependent Electromagnetically Induced Transparency in Hybrid Chiral Metamaterials
Authors: Kang Lei , Hao Jiang Zhi , Yue Taiwei , Werner Douglas H. 
Published: July 2015

AbstractWe provide the first experimental demonstration of the handedness dependent electromagnetically induced transparency (EIT) in chiral metamaterials during the interaction with circularly polarized waves. The observed chiral-sensitive EIT phenomena arise from the coherent excitation of a non-radiative mode in the component split ring resonators (SRRs) produced by the corresponding Born−Kuhn type (radiative) resonators that are responsible for the pronounced chirality. The coherent coupling, which is dominated by the bonding and antibonding resonances of the Born−Kuhn type resonators, leads to an extremely steep dispersion for a circularly polarized wave of predefined handedness. Accordingly, retrieved effective medium parameters from simulated results further reveal a difference of 80 in the group indices for left- and right-handed circularly polarized waves at frequencies within the EIT window, which can potentially result in handedness-sensitive pulse delays. These chiral metamaterials which enable a handedness dependent EIT effect may provide more degrees of freedom for designing circular polarization based communication devices.
Computational Prediction and Validation of BAHD1 as a Novel Molecule for UlcerativeColitis
Authors: Zhu Huatuo , Wan Xingyong , Li Jing , Han Lu , Bo Xiaochen , Chen Wenguo , Lu Chao , Shen Zhe , Xu Chenfu , Chen Lihua , Yu Chaohui , Xu Guoqiang 
Published: July 2015

AbstractUlcerative colitis (UC) is a common inflammatory bowel disease (IBD) producingintestinal inflammation and tissue damage. The precise aetiology of UC remainsunknown. In this study, we applied a rank-based expression profile comparativealgorithm, gene set enrichment analysis (GSEA), to evaluate the expression profilesof UC patients and small interfering RNA (siRNA)-perturbed cells to predict proteinsthat might be essential in UC from publicly available expression profiles. We usedquantitative PCR (qPCR) to characterize the expression levels of those genespredicted to be the most important for UC in dextran sodium sulphate (DSS)-inducedcolitic mice. We found that bromo-adjacent homology domain (BAHD1), a novelheterochromatinization factor in vertebrates, was the most downregulated gene. Wefurther validated a potential role of BAHD1 as a regulatory factor for inflammationthrough the TNF signalling pathway in vitro. Our findings indicate thatcomputational approaches leveraging public gene expression data can be used to inferpotential genes or proteins for diseases and BAHD1 might act as an indispensablefactor in regulating the cellular inflammatory response in UC.