bluuebunny/crossref_metadata_2025_split huggingface dataset:
Signature of circulating microRNAs in patients with acute heart failure
Authors: Ovchinnikova Ekaterina S. , Schmitter Daniela , Vegter Eline L. , ter Maaten Jozine M. , Valente Mattia A.E. , Liu Licette C.Y. , van der Harst Pim , Pinto Yigal M. , de Boer Rudolf A. , Meyer Sven , Teerlink John R. , O'Connor Christopher M. , Metra Marco , Davison Beth A. , Bloomfield Daniel M. , Cotter Gadi , Cleland John G. , Mebazaa Alexandre , Laribi Said , Givertz Michael M. , Ponikowski Piotr , van der Meer Peter , van Veldhuisen Dirk J. , Voors Adriaan A. , Berezikov Eugene 
Published: September 2015

AimsOur aim was to identify circulating microRNAs (miRNAs) associated with acute heart failure (AHF).Methods and resultsPlasma miRNA profiling included 137 patients with AHF from 3 different cohorts, 20 with chronic heart failure (CHF), 8 with acute exacerbation of COPD, and 41 healthy controls. Levels of circulating miRNAs were measured using quantitative reverse transcription–polymerase chain reaction (qRT–PCR). Plasma levels of miRNAs in patients with AHF were decreased compared with CHF patients or healthy subjects, whereas no significant changes were observed between acute COPD patients and controls. Fifteen miRNAs found in the discovery phase to differ most significantly between healthy controls and patients with AHF were further investigated in an extended cohort of 100 AHF patients at admission and a separate cohort of 18 AHF patients at different time points. Out of these 15 miRNAs, 12 could be confirmed in an additional AHF validation cohort and 7 passed the Bonferroni correction threshold (miR‐18a‐5p, miR‐26b‐5p, miR‐27a‐3p, miR‐30e‐5p, miR‐106a‐5p, miR‐199a‐3p, and miR‐652‐3p, all P < 0.00005). A further drop in miRNA levels within 48 h after AHF admission was associated with an increased risk of 180‐day mortality in a subset of the identified miRNAs.ConclusionsDeclining levels of circulating miRNAs were associated with increasing acuity of heart failure. Early in‐hospital decreasing miRNA levels were predictive for mortality in a subset of miRNAs in patients with AHF. The discovered miRNA panel may serve as a launch‐pad for molecular pathway studies to identify new pharmacological targets and miRNA‐based therapies.
Neurons and T cells: Understanding this interaction for inflammatory neurological diseases
Authors: Yshii Lidia , Gebauer Christina , Bernard‐Valnet Raphaël , Liblau Roland 
Published: September 2015

Central nervous system (CNS) inflammation occurs in a large number of neurological diseases. The type and magnitude of CNS inflammation, as well as the T‐cell contribution, vary depending on the disease. Different animal models of neurological diseases have shown that T cells play an important role in CNS inflammation. Furthermore, recent studies of human neurological disorders have indicated a significant role for T cells in disease pathology. Nevertheless, how individual T‐cell subsets affect neuronal survival, damage and/or loss remains largely unclear. In this review we discuss the processes by which T cells mediate either beneficial or deleterious effects within the CNS, with emphasis on the direct interaction between T cells and neurons, as occurs in multiple sclerosis, paraneoplastic cerebellar degeneration, and viral encephalitis. The therapeutic approaches targeting T cells and their mediators as treatment for neurological diseases are also described here.
Polyhalide Ions (Br82– and I2Br62–) and Chains (···Br3–···Br2··· and ···IBr4–···) Stabilised by Using Cu(dafone)32+ as Counter Ion (dafone = 4,5‐Diazafluoren‐9‐one)
Authors: Babu Ramavath , Bhargavi Govindugari , Rajasekharan Melath V. 
Published: September 2015

AbstractTwo new iodobromides [I2Br62– (analogue of I82– and Br82–) and IBr4– (analogue of Br5– and I2Br3–)] and new chains formed from Br3–, Br2 and IBr4– have been obtained in three compounds all containing the same CuII tris‐chelate cation Cu(dafone)32+ {[Cu(dafone)3](Br3)(Br5) (1), [Cu(dafone)3](Br5)(Br8)0.5·CH3CN (2) and [Cu(dafone)3](IBr4)(I2Br6)0.5·CH3CN (3)} by a procedure employing bromine, iodine, CuII bromide and dafone in acetonitrile. The formation of chains and isolated polyhalide ions is facilitated by templating with the tris‐chelate cation. The Raman spectra of the polyhalides and EPR and other spectral characteristics of the fluxional CuII complex cation are presented.
Optimal Synthesis of Faujasite‐Type Zeolites with a Hierarchical Porosity from Natural Clay
Authors: Ltaief Olfa Ouled , Siffert Stéphane , Poupin Christophe , Fourmentin Sophie , Benzina Mourad 
Published: September 2015

AbstractRaw clay, which is an interstratified illite‐kaolinite, has been used as a raw material to prepare Faujasite‐type zeolites. The synthesis was based on the alkaline fusion method followed by hydrothermal treatment without the addition of any extra silica or alumina sources. The effects of various factors on the synthesis process, such as NaOH/clay ratio, crystallization time and temperature, were investigated. The results obtained underlined that these parameters determined whether or not Faujasite‐type zeolites were formed. The optimum synthesis conditions for the synthesis of a single Faujasite zeolite phase were a weight ratio of NaOH/clay of 1.2 fused at 500 °C for 2 h and crystallized at 60 °C for 24 h after homogenization for 12 h. The compounds obtained were characterized by X‐ray diffraction, FTIR spectroscopy, and scanning electron microscopy. Their textural properties were investigated by N2 adsorption/desorption measurements. The BET surface area of the product synthesized with the optimum conditions was 360 m2/g with a relatively high total pore volume of 0.33 m3/g. Toluene adsorption on the synthesized trimodal Faujasite zeolite was four times higher than on commercial zeolite. This synthesis is therefore a good way to obtain a cheap and efficient adsorbent for environmental applications.
Combined Oxidation, Deprotonation, and Metal Coordination of a Redox‐Active Guanidine Ligand
Authors: Wild Ute , Kaifer Elisabeth , Wadepohl Hubert , Himmel Hans‐Jörg 
Published: September 2015

AbstractGuanidino‐functionalized aromatic compounds (GFAs) are strong organic electron donors and redox‐active ligands. The diversity of GFA chemistry results from reaction sequences that are triggered by their oxidation. This work reports on reactions of a new GFA compound, namely, 1,2,4,5‐tetrakis(N,N′‐dicyclohexylguanidino)benzene, with transition metals, and analyzes the interplay between GFA oxidation, coordination, and hydrogen‐bond formation up to deprotonation. The reaction of the new GFA with [{PdCl(C3H5)}2] led to coordination and a coupled proton‐ and electron‐transfer reaction.
Photoluminescence Modulation in Lan­thanide(III)/Pyrazine‐2,5‐dicarboxylato/Nitrato Frameworks
Authors: Cepeda Javier , Pérez‐Yáñez Sonia , Beobide Garikoitz , Castillo Oscar , García Jose Ángel , Luque Antonio 
Published: September 2015

AbstractInvited for the cover of this issue is the group of Oscar Castillo at the University of the Basque Country (UPV/EHU) in Bilbao, Spain. The cover image shows the suitability of the solvent‐free method to achieve a variety of 3D coordination polymers through reaction between lanthanide nitrates and pyrazine‐2,5‐dicarboxylic acid. Some of these compounds are photoluminescent and emit bright green, brown and bright red colours that are depicted by the traffic lights.
Clinical and pathological parameters prognostic for increased risk of recurrence after postoperative radiotherapy for temporal bone carcinoma
Authors: Marioni Gino , Zanoletti Elisabetta , Giacomelli Luciano , Braggio Leonardo , Martini Alessandro , Mazzoni Antonio 
Published: September 2015

AbstractBackgroundMost authors agree that radical surgery for advanced, aggressive temporal bone squamous cell carcinoma (SCC) should be followed by postoperative radiotherapy (PORT). The purpose of this study was to identify clinical and/or conventional pathological parameters capable of pinpointing patients with temporal bone SCC at higher risk of recurrence after PORT.MethodsThe investigation concerned 27 consecutive patients undergoing PORT for primary temporal bone SCC.ResultsUnivariate statistics revealed a difference in the distributions for pT classification (p = .0004), pathological grade (p = .006), and dura mater involvement (p = .015) when patients were grouped by presence versus absence of recurrence after PORT. A panel of 3 parameters comprising pT classification (pT4), pathological grade (G2 or G3), and dura mater involvement demonstrated an outstanding discriminatory power (area under the curve [AUC] receiver operating characteristic [ROC] = 0.912) in predicting temporal bone SCC recurrence after PORT.ConclusionThe panel considered had an outstanding discriminatory power in pinpointing patients at higher risk of recurrence who could benefit from stricter follow‐up protocols and postoperative chemoradiotherapy (CRT) for temporal bone SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: 894–898, 2016
Parotid metastasis of an amelanotic melanoma of the scalp: The great masquerader
Authors: Neto Tiago , Nunes Richard , Amado Isabel , Balhau Rui , Marques Hugo , Sanz David , Mesquita Margarida , Pinto Isabel , Correia‐Sá Inês , Ferreira Artur 
Published: September 2015

AbstractBackgroundCutaneous melanoma is often characterized by its pigmented appearance; however, up to 8.1% of such lesions contain little or no pigmentation. Amelanotic melanomas, lesions devoid of visible pigment, present a diagnostic quandary because they can masquerade as many other skin pathologies. Recognizing amelanotic melanoma is even more clinically challenging when it is first detected as a metastasis to the secondary tissue.MethodsWe report a rare case of metastasis of an amelanotic melanoma to the parotid gland.ResultsA 75‐year‐old man presented with an 8‐month history of a painless, mobile, hardened mass in the right parotid region. Histopathological analysis of a fine‐needle aspiration biopsy of the parotid mass indicated that the mass was melanoma. Careful clinical and radiological examination revealed an 8 mm erythematous papule in the right temporal scalp, initially diagnosed by visual examination as basal cell carcinoma. After right superficial parotidectomy, neck dissection, and excision of the temporal scalp lesion, histological examination revealed the scalp lesion to be amelanotic melanoma.ConclusionAlthough metastatic amelanotic melanoma to the parotid gland is a rare diagnosis, the clinician should be familiar with this presentation to increase the likelihood of making the correct diagnosis and delivering prompt treatment. © 2015 Wiley Periodicals, Inc. Head Neck 38: E91–E94, 2016
Vocal cord paralysis predicted by neural monitoring electrophysiologic changes with recurrent laryngeal nerve compressive neuropraxic injury in a canine model
Authors: Puram Sidharth V. , Chow Harold , Wu Che‐Wei , Heaton James T. , Kamani Dipti , Gorti Gautham , Chiang Feng Yu , Dionigi Gianlorenzo , Barczyński Marcin , Schneider Rick , Dralle Henning , Lorenz Kerstin , Randolph Gregory W. 
Published: September 2015

AbstractBackgroundRecurrent laryngeal nerve (RLN) injury is a known complication of thyroid/parathyroid surgery. Intraoperative nerve monitoring (IONM) has been used to gain more information regarding the functional status of the RLN intraoperatively; however, the electromyography (EMG) parameters of RLN after nontransection neuropraxic compressive injury remain unknown.MethodsWe developed a canine model to identify IONM EMG correlates of postoperative vocal cord paralysis (VCP) using a standardized method to simulate surgical RLN compression sufficient to cause VCP.ResultsCompression nerve injury decreased EMG amplitude and increased EMG latency, with a 60% increase in RLN threshold stimulation compared to preinjury values. If RLN amplitude decreases by 80% with an absolute amplitude of 300 μV or less in combination with a latency increase of 10% or more, then nerve injury and associated VCP is likely.ConclusionThese results may help surgeons to prognosticate postoperative neural function and intraoperative decision‐making regarding contralateral thyroid surgery. © 2015 Wiley Periodicals, Inc. Head Neck 38: E1341–E1350, 2016
Evaluation of Groundwater Suitability for Irrigation in the Araniar River Basin, South India—A Case Study Using Gis Approach
Authors: Jasmin I. , Mallikarjuna P. 
Published: September 2015

AbstractSpatial and temporal variations in the groundwater quality of the Araniar River Basin, south India, were studied to determine its suitability for irrigation through development of irrigation water quality index (IWQI) maps of post‐ and pre‐monsoon periods. The spatial thematic maps of electrical conductivity (EC), sodium absorption ratio (SAR), residual sodium carbonate (RSC) and sodium percentage (Na%) were developed using a geographic information system (GIS) and compared with the respective United States Department of Agriculture (USDA) standards. The pertinent maps of irrigation water quality parameters based on FAO‐29 guidelines were prepared, rasterized and overlaid using a GIS to develop IWQI maps for the basin. The IWQI maps indicated that 75% of the basin area possesses highly suitable irrigation water post‐monsoon, with medium suitability (90.7% of the basin) predominating during pre‐monsoon. Copyright © 2015 John Wiley & Sons, Ltd.
Assessment Of Cost‐Effective Alternatives For Improving Irrigation Systems In The Nile Delta
Authors: Abou El‐Hassan W.H. , El‐Kassar G. , Fujimaki H. , Kitamura Y. , Khater A. 
Published: September 2015

AbstractPreliminary studies were conducted to test new design criteria incorporated in the Sefsafa Canal (SC) with the aim of reducing water application costs without sacrificing irrigation performance. For comparison, we also studied the Meet‐Yazied Canal (MYC) (which is run without the new techniques). The cost‐reduction measures used in this study included reduction of pump discharge rates and the use of electricity instead of diesel. We found that the location of farms along the irrigation canal had little effect on pump operation hours and amount of applied water; instead, crop patterns were the most important factor in this regard. The water use index (WUI), which is the ratio of applied water to required water, was higher in the SC than in the MYC and El‐Mesk Canal (MC). Decreasing the pump discharge increased the amount of applied water to meet crop water requirements. During the winter, the WUI values of 1.11–1.16 achieved discharge rates of 70–80 l s−1 and were considered the optimal values of WUI. Further studies are required to avoid excessive application of water during the summer. The application of new techniques prompted farmers to irrigate their fields at night, thereby reducing water losses and installation and operational costs, and promoting equitable water distribution along the entire irrigation canal and throughout the command area. Copyright © 2015 John Wiley & Sons, Ltd.
Impact of neoadjuvant chemotherapy on pathologic axillary nodal status in HER‐2 positive patients presenting with clinically node‐negative disease
Authors: Al‐Hilli Zahraa , Hieken Tina J. , Hoskin Tanya L. , Heins Courtney N. , Boughey Judy C. 
Published: September 2015

ObjectivesWe investigated the impact of neoadjuvant chemotherapy (NAC) on axillary disease burden in clinically node‐negative (cN0) HER‐2 positive breast cancer patients.MethodsWe studied 215 cN0 patients with HER‐2 positive tumors. Multivariable logistic regression was used to compare NAC versus primary surgery (PS) with respect to outcome of pathologic nodal disease.ResultsOf 215 patients, 42 (20%) received NAC. NAC use correlated with higher clinical T stage (P < 0.0001) and younger age (P = 0.03) with no difference in ER/PR status or tumor grade. Despite higher clinical T stage in the NAC group, rate of pathologic positive axillary nodes was non‐significantly lower (NAC 5/42 = 11.9%, PS 27/173 = 15.6%, P = 0.54). In multivariable analysis, after adjustment for confounders including clinical T stage, age, and multifocal/multicentric disease, NAC showed significant reduction in odds of pathologic nodal disease (OR 0.26, 95%CI:0.06–0.90, P = 0.03). Further, among those with pathologic nodal disease, the number of positive nodes was lower after NAC (adjusted P = 0.03). Extranodal extension was present in 8/27 (30%) PS patients vs. 1/5 (20%) of the NAC patients (adjusted P = 0.36).ConclusionNAC in cN0 HER‐2 positive breast cancers reduces the rate of pathologic node‐positive disease at operation and nodal disease burden and may decrease the need for axillary node dissection. J. Surg. Oncol. 2015; 112:453–457. © 2015 Wiley Periodicals, Inc.
Shifts in microbial food web structure and productivity after additions of naturally occurring dissolved organic matter: Results from large‐scale lacustrine mesocosms
Authors: Sanders Robert W. , Cooke Sandra L. , Fischer Janet M. , Fey Samuel B. , Heinze Adam W. , Jeffrey Wade H. , Macaluso Amy L. , Moeller Robert E. , Morris Donald P. , Neale Patrick J. , Olson Mark H. , Dean Pakulski J. , Porter Jason A. , Schoener Donald M. , Williamson Craig E. 
Published: September 2015

AbstractPredicting the effects of dissolved organic matter (DOM) on pelagic food webs can be difficult because DOM modifies water column optics and can have contrasting effects on species across trophic levels. We combined large mesocosm, smaller‐scale experiments and autoregressive modeling driven bu DOC concentration or DOM optical quality (colored DOM, or CDOM, measured as DOC‐specific absorbance at 320 nm, SUVA320) to assess how heterotrophic and phototrophic microbial populations were altered in a temperate oligotrophic lake. DOM additions yielded DOC concentrations of 1.6 mg L−1 (control) 2.5 mg L−1, 3.0 mg L−1, and 4.3 mg L−1. Primary (PP) and bacterial (BP) production as well as heterotrophic and autotrophic protist abundances were stimulated in the higher DOM additions. BP responded rapidly to DOM additions, but unlike PP, returned to the level of controls within 2–7 d. A bioassay showed that the DOM was a nitrogen source for phytoplankton. The two models revealed that BP and edible phytoplankton were stimulated by CDOM (SUVA320), but only BP was stimulated by DOC concentration. Ultraviolet radiation (UV) inhibited protists in both models, but stimulated edible phytoplankton only in the SUVA320 model runs. These results suggest that in transparent oligotrophic lakes large influxes of terrestrial (high SUVA320) DOM will stimulate the microbial food web by providing a nutrient subsidy to bacteria and reducing exposure of protists to damaging UV. Nutrients associated with moderate DOM input may also stimulate PP relative to BP, as was observed in these and other experiments, rather than causing an overall system shift toward heterotrophy.
Selective plane illumination optical and optoacoustic microscopy for postembryonic imaging
Authors: Lin Hsiao‐Chun Amy , Chekkoury Andrei , Omar Murad , Schmitt‐Manderbach Tobias , Koberstein‐Schwarz Benno , Mappes Timo , López‐Schier Hernán , Razansky Daniel , Ntziachristos Vasilis 
Published: September 2015

AbstractIntravital imaging of large specimens is intrinsically challenging for postembryonic studies. Selective plane illumination microscopy (SPIM) has been introduced to volumetrically visualize organisms used in developmental biology and experimental genetics. Ideally suited for imaging transparent samples, SPIM can offer high frame rate imaging with optical microscopy resolutions and low phototoxicity. However, its performance quickly deteriorates when applied to opaque tissues. To overcome this limitation, SPIM optics were merged with optical and optoacoustic (photoacoustic) readouts. The performance of this hybrid imaging system was characterized using various phantoms and by imaging a highly scattering ex vivo juvenile zebrafish. The results revealed the system's enhanced capability over that of conventional SPIM for high‐resolution imaging over extended depths of scattering content. The approach described here may enable future visualization of organisms throughout their entire development, encompassing regimes in which the tissue may become opaque.
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Entrainment of vastus medialis complex activity differs between genders
Authors: Tenan Matthew S. , Hackney Anthony C. , Griffin Lisa 
Published: September 2015

ABSTRACTIntroduction: That the vastus medialis oblique (VMO) is a functional unit of the vastus medialis (VM) is disputed. Delayed VMO activation predicts patellofemoral pain, which has higher rates in women. Methods: Single MUs and surface electromyogram (EMG) were collected from the VMO and VM of 9 men and 9 women. Men were tested once; women were tested during 5 menstrual phases. Coherence was assessed for motor unit (MU) firings within and between the VM and VMO using multilevel logistic models to determine statistical significance. Results: Compared with women, men have 741% (MU pairs) and 256% (MU‐EMG pairs) greater odds of common drive (0–5 Hz) coherent oscillations. MU pairs from the VMO and the dual VM/VMO complex have 228% and 212% greater odds of coherent oscillations in the beta band (15–35 Hz) compared with VM pairs. Conclusions: The VM and VMO are neurologically different muscles; control of the VM complex is sexually dimorphic. Muscle Nerve 53: 633–640, 2016
A micromechanics model for molecular diffusion in materials with complex pore structure
Authors: Timothy Jithender J. , Meschke Günther 
Published: September 2015

SummaryMolecular diffusion in fully saturated porous materials is strongly influenced by the pore space, which, in general, is characterized by a complex topological structure. Hence, information on macroscopic diffusion properties requires up‐scaling of transport processes within nano‐pores and micro‐pores over several spatial scales. A new model in the framework of continuum micromechanics is proposed for predicting the effective molecular diffusivity in porous materials. Considering a representative volume element, characterizing a porous material without any information about the pore space microstructure complexity, the uniform flux is perturbed by recursively embedding shape information hierarchically in the form of the ESHELBY matrix‐inclusion morphology to obtain the effective diffusivity as a function of the recurrence level and the porosity. The model predicts a threshold value for the porosity, below which no molecular diffusion can occur because of the presence of isolated pore clusters that are not connected and unavailable for transport. The maximum porosity, below which no molecular transport is possible, is predicted as one‐third for spherical inclusions. The model allows for extensions to more complex morphologies of the inclusions. We also identify, that the effects of the micro‐structure on molecular transport are characterized by porosity dependent long‐range and short‐range interactions. The developed framework is extended to incorporate realistic pore size distributions across several spatial scales by means of a distribution function within the hierarchical homogenization scheme. Available experimental results assert the model predictions. Copyright © 2015 John Wiley & Sons, Ltd.