bluuebunny/crossref_metadata_2025_split huggingface dataset:
TDP1 phosphorylation by CDK1 in mitosis promotes MUS81-dependent repair of trapped Top1-DNA covalent complexes
Authors: Paul Chowdhuri Srijita , Das Benu Brata 
Published: July 2024

AbstractTopoisomerase 1 (Top1) controls DNA topology, relieves DNA supercoiling during replication and transcription, and is critical for mitotic progression to the G1 phase. Tyrosyl-DNA phosphodiesterase 1 (TDP1) mediates the removal of trapped Top1-DNA covalent complexes (Top1cc). Here, we identify CDK1-dependent phosphorylation of TDP1 at residue S61 during mitosis. A TDP1 variant defective for S61 phosphorylation (TDP1-S61A) is trapped on the mitotic chromosomes, triggering DNA damage and mitotic defects. Moreover, we show that Top1cc repair in mitosis occurs via a MUS81-dependent DNA repair mechanism. Replication stress induced by camptothecin or aphidicolin leads to TDP1-S61A enrichment at common fragile sites, which over-stimulates MUS81-dependent chromatid breaks, anaphase bridges, and micronuclei, ultimately culminating in the formation of 53BP1 nuclear bodies during G1 phase. Our findings provide new insights into the cell cycle-dependent regulation of TDP1 dynamics for the repair of trapped Top1-DNA covalent complexes during mitosis that prevents genomic instability following replication stress.
EF‐CorrCA: A multi‐modal EEG‐fNIRS subject independent model to assess speech quality on brain activity using correlated component analysis
Authors: Charly Djimeli Tsamene , Onabid Mathias 
Published: July 2024

AbstractAn investigation on the effect of mental activity in quality perception is presented using simultaneous measurement of electroencephalography (EEG) and functional near‐infrared spectroscopy (fNIRS), in a subject‐independent approach. Building a subject‐independent model is a harder problem due to noise and high EEG variability between individuals, correlated components analysis (CorrCA) have been proposed to extract significant correlated components for a single subject that experiences multiple identical trials; this is done by identifying spatio‐temporal patterns of activity that are well preserved across trials. The aim is to build a model based on neurophysiological data to assess text‐to‐speech quality. In order to build a subject independent model, we extended the use of CorrCA such that it can be applied to the subject independent model. The authors used two preprocessing steps, namely the subject dependent and the stimulus dependent preprocessing. The second preprocessing used the denoising source separation (DSS) to remove noise/artefact that are subject specific. The discrete convolution is used for data fusion and the support vector machine for regression. With the proposed model, the fusion of EEG and fNIRS performs better than single modality. Using our defined regression accuracy metrics, the authors obtained accuracy of 81.346% for overall impression, 83.28% for valence and 89.714% for arousal. The model compete the baseline that is subject dependent.
A passive beamforming hemispherical liquid antenna using a simple metal ball
Authors: Gudivada Viswanadh Raviteja , Huang Yi , Bennett Elliot L. 
Published: July 2024

AbstractThe authors propose a novel yet simple way of passive beamforming using a liquid antenna. A hemispherical dielectric resonator antenna filled with a dielectric liquid is considered to realise the fundamental TE111 mode, and a small, weighted metal ball is dropped inside the hemispherical container. This metal ball functions as a movable director and passively steers the realised fundamental mode of the DRA always towards the ground. The proposed design finds its applications in static‐subject‐based applications such as indoor base stations, and beam‐stabilisation/pattern‐correction works in case of dynamic‐subject‐based applications. The overall profile of the antenna is 0.60λ0 × 0.60λ0 × 0.19λ0 targeting the ISM band at 2.4 GHz with decent efficiency and far‐field characteristics. The working prototype is developed and experimentally verified.
Probabilistic assessment of short‐term voltage stability under load and wind uncertainty
Authors: Alzubaidi Mohammed , Hasan Kazi N. , Meegahapola Lasantha , Rahman Mir Toufikur 
Published: July 2024

AbstractContemporary electricity networks are exposed to operational uncertainties, which may jeopardise the stability of the power grid. More specifically, the increasing penetration level of variable renewable energy generation and uncertainty in load demand are key catalysts for these emerging stability issues. A mathematical relationship is established to track the system voltage trajectory with respect to variations in uncertain inputs (associated with wind speed, system load, and wind power penetration levels). Additionally, it demonstrates the consequences of varying uncertain inputs on the short‐term voltage response across different potential operating conditions. The theoretical proposition has further been verified by the simulation studies with two test power networks in DIgSILENT PowerFactory software. The simulation results revealed that uncertain injection sources significantly impacted the system voltage at the receiving end. High uncertainty in wind speed and system loads increased voltage recovery variation, causing delays in voltage response during low wind speeds and high system loads. Additionally, increased wind power penetration levels expanded voltage recovery uncertainties, resulting in decreased system voltage and potentially leading to voltage violations and instability at 30% wind power levels. Moreover, the results showed that the system's response time increased, and in some cases, it collapsed due to increased system capacity (>80%) and dynamic load (>75%), as well as encountering a large disturbance under uncertain circumstances.
Profile und Merkmale psychiatrischer Pflegefachpersonen in der
gemeindenahen Gesundheitsversorgung von Menschen mit psychischen Erkrankungen –
Integratives Review und thematische Framework Analyse
Authors: Scheydt Stefan , Hegedüs Anna 
Published: July 2024

Zusammenfassung
Ziel Exploration der spezifischen Tätigkeitsfelder von Community Mental
Health Nurses (CMHNs) innerhalb verschiedener CMHN-Rollen und
Versorgungskontexte.
Methoden Systematische Literaturrecherche in CINAHL, PubMed/Medline,
Google und Google Scholar, ergänzt durch eine Suche in verschiedenen
Verlagsdatenbanken. Die Analyse und Synthese der Daten erfolgte in Anlehnung an
die Methode der Framework Analyse.
Ergebnisse Es wurden zwei Rollenprofile von CMHNs identifiziert, die
unterschiedliche Funktionen in der ambulanten Versorgung von psychisch kranken
Menschen beschreiben: (A) Primary Care CMHN und (B) Specialized Care CMHN. Für
jedes Rollenprofil werden kontextuelle Faktoren und spezifische Rolleninhalte
beschrieben und im Hinblick auf Gemeinsamkeiten und Unterschiede analysiert.
Schlussfolgerungen Die beschriebenen Rollenprofile können als Vorlage für
die Entwicklung von Curricula im Bereich CMHN dienen. Hier ist es wichtig, den
nationalen Kontext sowie den vorherrschenden und zukünftigen psychosozialen
Versorgungsbedarf zu berücksichtigen.
Die moderne TARE 2023 – von der Palliativversorgung zur kurativen Behandlungsalternative
Authors: Gebauer Bernhard , Collettini Federico , Pfob Christian Helmut , Lapa Constantin 
Published: July 2024

ZusammenfassungDie selektive interne Radiotherapie (SIRT) oder transarterielle Radioembolisation (TARE) ist eine Behandlungsalternative beim hepatozellulären Karzinom (HCC) oder hepatisch metastasierten kolorektalen Karzinom (mCRC) und ist mittlerweile in vielen Leitlinien verankert. Der Artikel fasst die aktuellen Leitlinien zur SIRT/TARE beim HCC bzw. mCRC zusammen.
Thiourea/NCBSI/HCl System: Telescoping Alkyl Halide to Alkyl Sulfonyl Chloride by Recyclable N-Chloro-N-(phenylsulfonyl)benzene Sulfonamide (NCBSI)
Authors: Chaturbhuj Ganesh U. , Gaikwad Shweta S. 
Published: July 2024

AbstractA convenient and efficient method to synthesize diverse alkyl sulfonyl chlorides through N-chloro-N-(phenylsulfonyl)benzene sulfonamide (NCBSI)-mediated oxidative chlorosulfonation of S-alkyl isothiouronium salts obtained from alkyl chlorides is presented. Synthesizing structurally diverse alkyl sulfonyl chloride in moderate to excellent yields up to 98% from alkyl halide was achieved via easy formation of S-alkyl isothiouronium salts using inexpensive thiourea. The mild reaction conditions and broad substrate scope make this method attractive for alkylsulfonyl chloride syntheses.
Phosphazene-Catalyzed Cascade Esterification/Stereoselective Aza-Michael Addition of Chiral β-Trifluoromethyl-α,β-unsaturated N-Acylated Oxazolidin-2-ones
Authors: Soorukram Darunee , Racochote Sasirome , Kuhakarn Chutima , Leowanawat Pawaret , Reutrakul Vichai 
Published: July 2024

AbstractUpon treatment of chiral β-trifluoromethyl-α,β-unsaturated N-acylated oxazolidin-2-ones with a range of alcohols using phosphazene base as a catalyst, the unexpected cascade esterification/stereoselective aza-Michael addition was observed. The reactions proceeded with high diastereoselectivities (up to >99:1) to give a series of enantioenriched aza-Michael addition products in good to high yields. The structure and stereochemistry of the representative aza-Michael adduct were confirmed by X-ray crystal structure analysis. The plausible mechanism was proposed on the basis of the experimental results.The synthetic transformations of chiral aza-Michael addition products were also demonstrated highlighting the synthetic application of the present work.
Assessing the Quality of Life in Hydrocephalic Children: A Study from Tertiary Care Hospitals in Pakistan
Authors: Khan Arshad , Akbar Neelam , Abbas Sameen , Mushtaq Saima , Ahmad Nafees , Khan Amjad 
Published: July 2024

Abstract
Background Hydrocephalus is a neurological disease with higher prevalence in the pediatric population, often managed by placing a shunt. This hollow tube drains excess cerebrospinal fluid from the brain to other body parts, resulting in several complications, including neurological and psychometric manifestations and a compromised quality of life (QoL). This study aimed to evaluate QoL in patients with hydrocephalus shunt placement within the pediatric population.
Methods This prospective observational study was conducted in two major Pakistani tertiary care hospitals. A total of 100 subjects were enrolled, of which 52 were found eligible. A validated questionnaire, Hydrocephalus Outcome Questionnaire, was used to evaluate patients' QoL.
Results This study included pediatric patients with a mean age of 6.54 years and a standard deviation of ± 2.64. The male-to-female ratio was 27:25; 2% of patients had congenital or tumor-induced hydrocephalus, while cases of meningitis, encephalocele, and encephalitis accounted for 8, 4, and 2%, respectively. Myelomeningocele had the highest prevalence at 16%. The overall health scores range from 0.39 to 0.51. Social, cognitive, and physical health scores have mean values of 0.54, 0.50, and 0.48, respectively. The minimum physical health score is 0.17, indicating the most significant impact of hydrocephalus on physical function.
Conclusion This study highlights variations in hydrocephalus severity among pediatric patients, impacting their overall QoL, primarily physical and behavioral functioning. Worse health outcomes were associated with frequent seizures, prolonged hospital stays for diagnosis and treatment, shunt infections, increased number of shunt catheters, and longer travel distances to medical facilities.
Recent Advances in the Synthesis of Bicyclo[3.1.1]heptanes
Authors: Dong Jianyang , Xue Dong , Liao Huijuan 
Published: July 2024

AbstractIn the past three years, bicyclo[3.1.1]heptanes and their structural analogues have emerged as useful bioisosteres of meta-substituted (hetero)arenes. To meet the increasing demand for bicyclo[3.1.1]heptanes, chemists have developed a plethora of novel methods for their synthesis. In this short review, we assess the research progress on their synthesis and functionalization, considering both the scope and mechanistic aspects. In addition, we discuss the posed challenges and the outlook for the identification of new reaction manifolds to access novel functionalized bicyclo[3.1.1]heptanes.1	Introduction2	Synthesis of Bicyclo[3.1.1]heptanes (BCHeps)3	Synthesis of 3-Azabicyclo[3.1.1]heptanes (3-Aza-BCHeps)4	Conclusion and Outlook
N-Heterocyclic Carbene Catalyzed Reassembly of Dibenzyl Ethers: Facile Access to α-Hydroxy Ketones
Authors: Ju Lei , Wang Teng , Yu Xinhong , Li Zheyao , Bao Ruipeng , Lin Xinbo 
Published: July 2024

AbstractA novel one-pot cascade process of oxidation-initiated, N-heterocyclic carbene catalyzed, reintegration of dibenzyl ethers has been developed for the first time. This protocol allows straightforward access to α-hydroxy ketones from dibenzyl ethers. It is noteworthy that the present method is the first attempt to synthesize benzoin from dibenzyl ether.
Pd-Catalyzed Transfer Hydrogenation of Alkenes Using Tetrahydroxydiboron as the Sole Hydrogen Donor
Authors: Stokes Benjamin J. , Yaghoubi Mahshid , Reyes Isabella C. 
Published: July 2024

AbstractTetrahydroxydiboron-mediated catalytic transfer hydrogenations have typically involved co-additives that, like tetrahydroxydiboron itself, are H atom donors. Herein we report an alkene transfer hydrogenation method with tetrahydroxydiboron as the sole source of H atoms. The reaction uses Pd(OAc)2 as a convenient putative colloid pre-catalyst, and cyclic monoethers are competent solvents. Highly efficient alkene deuteration is demonstrated using tetradeuteroxydiboron.
Zinc Carbenoid-Promoted Methylene Insertion in Saturated Heterocycles: Mechanistic Insights and Reactivity Profiles
Authors: Nakamura Hiroyuki , Tsuda Masato 
Published: July 2024

AbstractThe ring expansion of saturated heterocycles through methylene insertion into N–O bonds using a zinc carbenoid is described. This transformation is applied to 1,2-oxazetidines and 1,2-oxazolidines, while N-tosylated 1,2-oxazinane affords a ring-opened product. Density functional theory calculations suggest a stepwise reaction mechanism of the ring expansion and elucidate the origins of the different reactivities observed.
Establishing H Angle Hard Tissue and H Angle Soft Tissue Norms in Skeletal Class I Malay Adult Females and the Correlation between the H Angles and Visual Perception of Laypersons
Authors: Cheong Joo Ming , A. Halim Nur Adlina , Mohammad Norsyamimi , Sivagnanam Mangaiyarkarasi , Mohd Ibrahim Mohamad Shafiq 
Published: July 2024

Abstract
Objectives This study aimed to establish the cephalometric norms of H angle soft tissue and H angle hard tissue of Malaysian Malay adult females, and to evaluate the correlation between H angles and visual perception in skeletal Class I Malay adult females.
Materials and Methods Eighty-five lateral cephalograms of skeletal Class I (mean ANB value = 3.15 ± 0.77) Malaysian Malay female patients aged 20 to 40 years (mean age = 28.6 ± 5.86 degrees) taken from October 2017 to December 2021 were measured for H angle soft tissue and H angle hard tissue. Twenty silhouettes were then converted from cephalometric films and were rated according to facial convexity/concavity by 20 laypersons, with re-evaluation after 2 weeks for intra- and interexaminer reliabilities.
Results The means of the H angle soft tissue and H angle hard tissue were 15.75 ± 4.16 degrees and 11.64 ± 4.71 degrees, respectively. The intraexaminer reliability test for visual perception ranged from −0.89 to 0.99 indicating poor to excellent reliability, whereas the interexaminer reliability test was 0.82 indicating good reliability. A highly statistically significant association between the H angle soft tissue and H angle hard tissue (r = 0.938; p < 0.01) was found. There was no correlation between H angles and visual perception.
Conclusion The cephalometric norms of H angle hard tissue and H angle soft tissue in the Malaysian Malay female population were established: 11.64 degrees (±4.71 degrees) and 15.75 degrees (±4.16 degrees), respectively. There was a strong correlation between H angle soft tissue and H angle hard tissue among skeletal Class I Malay adult females. There was no correlation between H angles and the visual perception of laypersons.
Preosteoblast Adhesion and Viability Study of Freeze-Dried Bovine Bone Block Scaffold Coated with Human Umbilical Cord Mesenchymal Stem Cell Secretome
Authors: Putri Arum Nur Kartika , Kamadjaja David Buntoro , Rizqiawan Andra , Amir Muhammad Subhan , Sumarta Ni Putu Mira , Paramita Dewi Kartikawati 
Published: July 2024

Abstract
Objectives Combining a three-dimensional scaffold with growth factors before implantation is one method used to increase scaffold bioactivity in bone tissue engineering. The mesenchymal stem cell (MSC)–conditioned medium (CM), called secretome, contains many proteins and growth factors required for tissue repair and growth. This study evaluated the bioactivity of a bovine bone scaffold combined with the secretome of human umbilical cord MSCs (hUC-MSCs) by analyzing MC3T3-E1 cell adhesion and viability on the scaffold.
Materials and Methods This in vitro laboratory study evaluated the effect of hUC-MSC secretome applied to bovine bone scaffolds processed using various techniques on MC3T3-E1 cell adhesion and viability. The three experimental groups included deproteinized bovine bone mineral–secretome (DBBM-CM), freeze-dried bovine bone–secretome (FDBB-CM), and decellularized FDBB-CM, whereas the control group was treated with DBBM alone. The cell adhesion test was performed using the centrifugation method after 6 and 24 hours, whereas the cell viability test was conducted using the trypan blue exclusion method after 24, 48, and 72 hours. Cell attachment was visualized after 4′,6-diamidino-2-phenylindole staining and viewed under inverted fluorescence microscopy.
Stastical Analysis Statistical analyses were performed using one-way analysis of variance, followed by a post hoc test in cases of significant differences.
Results Statistical analyses showed significantly greater adhesion of the preosteoblasts to the FDBB-CM scaffold at 6 hours (p = 0.002). The results of the adhesion test at 24 hours and the viability tests at all observation times showed no significant differences (p > 0.05). This study found that the average MC3T3-E1 cell adhesions and viabilities were highest for the FDBB-CM and DBBM-CM scaffolds. DBBM scaffolds with the secretome had better cell adhesion and viability than those without the secretome.
Conclusion The addition of MSC secretome increased bovine bone scaffold bioactivity especially in DBBM and FDBB scaffolds.
Evaluation of Microstrain in the Regions Surrounding Morse Taper and External Hexagon Implants
Authors: Moreno André Luiz de Melo , Campaner Marcio , de Moraes Melo Neto Clóvis Lamartine , Moreno Nathaly Vilene de Araújo , dos Santos Daniela Micheline , Goiato Marcelo Coelho 
Published: July 2024

Abstract
Objective The aim of this study was to compare the Morse taper (MT) + titanium base (Ti-Base) abutment with the external hexagon (EH) + Ti-Base abutment by using the strain gauge method in the mesial, distal, and apical–buccal areas around these types of implants.
Materials and Methods This study investigated two groups, MT and EH, each comprising five polyurethane samples with a dental implant (3.75 × 11.5 mm) in the area of artificial tooth 15. The strain gauges were glued to the mesial, distal, and apical–buccal polyurethane areas of all samples in relation to the implant. Ti-Base nonangled abutments were installed on the implants in each group. Ten identical zirconia crowns were constructed by scanning and milling and were subsequently cemented onto the Ti-base abutments with calcium hydroxide cement. Then, an axial load of 100 N was applied to the occlusal region of the zirconia crowns, and strain gauge measurements were taken.
Statistical Analysis Strain gauge data were assessed by a two-way analysis of variance (ANOVA) with “implant connection” and “strain gauge position” factors, followed by the Bonferroni test (p < 0.05).
Results The MT group showed significantly lower microstrain values in the mesial and apical strain gauges compared to the EH group.
Conclusion The MT group exhibited less microstrain in the mesial and apical areas of the polyurethane samples near the implant. Consequently, the MT connection was considered more biomechanically advantageous.
Efficacy of Ultrasound-Guided Injection of Platelet-Rich Plasma in Treatment of Sports-Related Meniscal Injuries
Authors: Raju Prabakar Singh , Sriraghavan Makesh Ram , Jayaraman Pazhani , Balasubramaniam Bheeshma , Karuppiah Karthik Shanmugavel , Kumararaja Poornima 
Published: July 2024

Abstract
Purpose Meniscal injuries are a common occurrence in sports-related activities, often leading to pain, reduced joint function, and impaired athletic performance. This study aimed to evaluate the role of ultrasound-guided intra-articular platelet-rich plasma (PRP)-rich fluid injection which was obtained through serial centrifugation in the treatment of meniscal injuries resulting from sports activities.
Materials and Methods A prospective study was conducted involving 54 cases with grade I, II, and III meniscal injuries, aged 18 and 43 years. PRP-rich fluid was prepared by subjecting autologous blood samples to a two-step centrifugation process. Patients were assessed pretreatment and at regular intervals posttreatment.
Results Patients reported reduced pain and improved joint functionality following treatment. Average age of the patients was 34.4 years, and average follow-up period was 275.1 days. It is noteworthy that no cases of bilateral meniscal injuries were identified; indicating that the focus was primarily on single knee injuries. Predominance of grade II injuries suggests that the PRP intervention might be particularly effective in addressing more severe meniscal tears.
Conclusion The results of our study provide compelling evidence for the positive impact of PRP augmentation in meniscus repair. Our findings indicate that PRP therapy has the potential to bring about substantial benefits for individuals with meniscus tears of the knee, particularly in terms of pain relief and enhanced functional capabilities.
Neurotrauma and Cerebrospinal Fluid in Homer's Poems
Authors: Borroto Carlos Enrique Hernández , Hernández Orquidia Reyes de , Plana Yuri Medrano 
Published: July 2024

AbstractHomer's Iliad, from the 8th century BC, remains the oldest record of Greek medicine and a unique source of surgical history. The Odyssey, also authored by Homer, narrates several medically significant events. Among the 148 war traumas described in the Iliad, over a quarter occurred in the craniocervical region. Studies on the Odyssey report at least 11 craniocervical traumas, 9 of which prove fatal. Is there any indication of the presence of cerebrospinal fluid (CSF) in the cases described by Homer, considering its last mention was 800 years prior in the Egyptian surgical papyrus of Edwin Smith? A passage in the Iliad suggests that the “tears” Homer mentions in the eyes of Eumelos, resulting from trauma, might be due to CSF oculorrhea secondary to a skull base fracture. In Odyssey Book IX, when the Cyclops strikes the heads of two sailors, and fluid and cranial contents emerge, it can be inferred that the poet was aware of fluid in the head (CSF), as there is no mention of blood. It is proposed that 800 years after the writing of the Edwin Smith papyrus, Homer probably provides the second human observation of CSF associated with traumatic situations involving direct head blows.