bluuebunny/crossref_metadata_2025_split huggingface dataset:
Clustering analyses in peptidomics revealed that peptide profiles of infant formulae are descriptive
Authors: Lambers Tim T. , Gloerich Jolein , van Hoffen Els , Alkema Wynand , Hondmann Dirk H. , van Tol Eric A.F. 
Published: December 2014

AbstractPrompted by the accumulating evidence on bioactive moieties of milk‐derived peptides, novel methods were applied to compare the peptide composition among commercially available hydrolysate formulations and to determine batch‐to‐batch variations of protein hydrolysate products. Despite the availability of general methods to measure, for example, the degree of hydrolysis and peptide mass distribution at a high level, the objective of this study was to more qualitatively compare peptide sequences and composition. By a comprehensive approach combining peptidomics technologies and multivariate clustering analyses, the peptide profiles of different hydrolyzed milk protein formulations were compared. Moreover, peptide profiles of various hydrolysate batches that had been produced over a period of 5 years were included. Coupling of identified peptide sequences to the position in their corresponding milk proteins produced numerical datasets that subsequently were utilized for multivariate data analyses. These analyses revealed that batch‐to‐batch variation in the peptide profiles of a specific extensively hydrolyzed casein preparation was low. Moreover, extensive multivariate evaluations revealed that the peptide profiles of different commercially available hydrolyzed milk protein formulations provided a descriptive and distinct signature. Overall, the described methodology may contribute to the field of peptide research as observed dissimilarities in peptide profiles of similar products may be related to differences in their overall functionality.
Effect of storage and cooking on the fatty acid profile of omega‐3 enriched eggs and pork meat marketed in Belgium
Authors: Douny Caroline , El Khoury Rawad , Delmelle Julien , Brose François , Degand Guy , Moula Nassim , Farnir Frédéric , Clinquart Antoine , Maghuin‐Rogister Guy , Scippo Marie‐Louise 
Published: December 2014

AbstractThe fatty acids (FA) profile was determined in n‐3 enriched (Columbus™) Belgian eggs and pork in order to evaluate to what extent the n‐3 fatty acids, which are very sensitive to oxidation, are resistant to storage or cooking. In standard eggs or pork, no change of the fatty acid profile was observed after storage or cooking without culinary fat, as well as in Columbus™ eggs and pork after storage. Some cooking processes (eggs in custard and meat in oven) induced a slight significant loss of n‐3 fatty acids in Columbus™ eggs or pork (11.1% in fat from eggs cooked in custard vs. 15.3% in raw Columbus™ eggs and 11.0% in fat from oven cooked meat vs. 11.6% in raw Columbus™ meat). As expected, when Columbus™ pork is cooked with culinary fat, its fatty acid profile is modified according to the nature of the fat used.
Gene delivery in tissue engineering and regenerative medicine
Authors: Fang Y. L. , Chen X. G. , W. T. Godbey 
Published: December 2014

AbstractAs a promising strategy to aid or replace tissue/organ transplantation, gene delivery has been used for regenerative medicine applications to create or restore normal function at the cell and tissue levels. Gene delivery has been successfully performed ex vivo and in vivo in these applications. Excellent proliferation capabilities and differentiation potentials render certain cells as excellent candidates for ex vivo gene delivery for regenerative medicine applications, which is why multipotent and pluripotent cells have been intensely studied in this vein. In this review, gene delivery is discussed in detail, along with its applications to tissue engineering and regenerative medicine. A definition of a stem cell is compared to a definition of a stem property, and both provide the foundation for an in‐depth look at gene delivery investigations from a germ lineage angle. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 103B: 1679–1699, 2015.
Delayed presentation of major complications in patients undergoing cytoreductive surgery plus hyperthermic intraperitoneal chemotherapy following hospital discharge
Authors: Bhagwandin Shanel B. , Naffouje Samer , Salti George 
Published: December 2014

IntroductionPeritoneal surface malignancy is increasingly treated with cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC). This is associated with potentially high morbidity. We analyzed the incidence of delayed major complications following CRS plus HIPEC.MethodsDelayed events were chosen as those which occurred after discharge from the hospital following CRS plus HIPEC and prior to 90 days. Major complications included any adverse event requiring intervention or intensive care unit admission.ResultsOne hundred thirty six patients underwent 140 procedures. Eight patients (5.7%) developed delayed major complications. Complications were pancreatic pseudocyst/pancreatitis (n = 3), abdominal wall dehiscence (n = 2), gastric perforation (n = 1), and ureteral stricture with associated hydronephrosis (n = 2).All of the patients had undergone multivisceral resections. Seven patients achieved complete cytoreduction (cc ≤ 1). Mean peritoneal carcinomatosis index (PCI) was 15.25 ± 5.33 (6–22). Standard of care was met for the management of all the complications and all patients recovered following intervention without any further morbidity or mortality.ConclusionThere is a lack of report of the delayed major complications in patients undergoing CRS plus HIPEC in the literature. Awareness should be raised among health care providers regarding possible occurrence of such late complications given that many patients undergo CRS plus HIPEC remotely from their localities. J. Surg. Oncol. 2015 111:324–327. © 2014 Wiley Periodicals, Inc.
Clinical experience of seropositive ganglionic acetylcholine receptor antibody in a tertiary neurology referral center
Authors: Li Yuebing , Jammoul Adham , Mente Karin , Li Jianbo , Shields Robert W. , Vernino Steven , Rae‐Grant Alexander 
Published: December 2014

ABSTRACTIntroduction: Antibody against the acetylcholine receptor of autonomic ganglia (gAChR‐Ab) is implicated in the pathogenesis of autoimmune autonomic ganglionopathy (AAG) and several other disorders. Methods: This study was a retrospective evaluation of 95 patients positive for gAChR‐Ab. Results: Twenty‐one (22%) patients had AAG, with a greater median gAChR‐Ab level (0.21 nmol/L) and higher percentage (57%) of antibody levels >0.20 nmol/L when compared with the remaining 74 patients without autonomic manifestations (non‐AAG group, 0.10 nmol/L and 15%, respectively). Only 2 new cases of malignancy were diagnosed after gAChR‐Ab detection. The non‐AAG group was associated with high frequencies of neurological and non‐neurological autoimmunity, but also included 23 (31%) patients with mostly degenerative disorders. Conclusion: Detection of gAChR‐Ab, especially at a higher level, is helpful for the diagnosis of AAG in patients with corresponding autonomic symptoms. However, its value is limited for predicting cancer risk and for diagnosis and management of patients without autonomic symptoms. Muscle Nerve 52:386–391, 2015
Clinicopathologic analysis of spindle cell/sclerosing rhabdomyosarcoma
Authors: Yasui Naoko , Yoshida Akihiko , Kawamoto Hiroshi , Yonemori Kan , Hosono Ako , Kawai Akira 
Published: December 2014

BackgroundClinical characteristics and optimal treatment strategies for spindle cell/sclerosing rhabdomyosarcoma (ssRMS) have not been well established because of its rarity.ProcedureRetrospective re‐evaluation of sarcoma specimens (1997–2014) identified 16 ssRMSs (median age 20 years, range 7–39 years). Clinicopathological features, clinical course, and outcome were analyzed.ResultsPrimary disease sites were the head and neck (10 cases) and other regions (6 cases). Nine cases were at Intergroup Rhabdomyosarcoma Study preoperative stage 3. The primary tumors were >5 cm in 13 cases. Two patients had lymph node metastases, but none had distant metastases at presentation. At follow‐up (median period 39 months, range 4.6–201), seven patients were alive without disease. Among nine patients treated with the vincristine, actinomycin, and cyclophosphamide (VAC) regimen, five responded well, with four surviving free of disease. Among ten patients with recurrent or progressive disease, three experienced local recurrence, four had distant metastases, and three had both. None exhibited bone marrow invasion. Eight of the ten patients died in median time from relapse to death of 18 months (range 11–56).ConclusionsAlthough most ssRMSs present as a bulky tumor, nodal or distant metastases are rare at presentation. ssRMSs initially show good response to VAC, but >50% of tumors recur or progress; these data suggest a worse prognosis of ssRMS compared to the pediatric embryonal variant. As relapse typically occurs as local or distant solitary lesion without bone marrow invasion, localized treatment combined with chemotherapy would contribute to improve the prognosis of recurrent ssRMS. Pediatr Blood Cancer 2015;62:1011–1016. © 2014 Wiley Periodicals, Inc.
Body composition parameters and adipokines levels in relation to bone mineral density in patients with malignant bone tumors after treatment
Authors: Ambroszkiewicz Jadwiga , Chelchowska Magdalena , Szamotulska Katarzyna , Rychlowska‐Pruszyńska Magdalena , Rowicka Grażyna , Gajewska Joanna 
Published: December 2014

BackgroundRecent data support the concept that adipokines, which are secreted by fat cells, are important modulators of bone metabolism. The aim of this study was to assess the relationships between body composition parameters, adipokines (leptin, adiponectin) and bone mineral density (BMD) in patients with malignant bone tumors after anticancer therapy.ProcedureThe study included 35 patients (median age 14.8 years) with diagnosed malignant bone tumors treated according to obligatory protocols. Total fat mass, lean mass, bone mineral content (BMC) and BMD measurements were performed after treatment completion by dual energy‐ray absorptiometry (DXA). Serum concentrations of leptin, leptin receptor and adiponectin were determined using immunoenzymatic assays. The control group consisted of 28 healthy children (median age 14.3 years).ResultsPatients with bone tumor after chemotherapy had significantly higher fat mass (P < 0.01), increased ratio of fat mass/lean mass (P < 0.001), and a decrease (P < 0.001) in total body and lumbar spine BMD compared with controls. We observed higher serum leptin concentration (P < 0.01) and lower soluble leptin receptor (P < 0.001) and adiponectin (P = 0.01) in patients than in controls. The ratios of leptin/leptin receptor and leptin/adiponectin were about three‐fold higher in patients compared with the control group (P = 0.001). We found a significant positive correlation between BMD and body composition and a negative correlation between BMD and adiponectin in the patients group.ConclusionsChanges in body composition parameters coexisting with disturbed adipokine levels, especially higher levels of leptin and lower levels of adiponectin, might be associated with bone status in patients treated for malignant bone tumors. Pediatr Blood Cancer 2015;62:988–993. © 2014 Wiley Periodicals, Inc.
Xanthates designed for the preparation of N‐Vinyl pyrrolidone‐based linear and star architectures via RAFT polymerization
Authors: Johnson Iain J. , Khosravi Ezat , Musa Osama M. , Simnett Rose E. , Eissa Ahmed M. 
Published: December 2014

ABSTRACTNovel xanthate RAFT agents, RAFT1‐5, designed for the preparation of a range of novel N‐vinyl pyrrolidone‐based polymeric materials with linear and star architectures via RAFT polymerization are reported. Ethyl pyrrolidone moiety was included in the structures of the xanthates as a part of R (RAFT1‐3) or Z group (RAFT4) to evaluate their effect on the polymerization and to impart homogeneity in the resulting products. The xanthates were designed to fragment to give primary (RAFT1), secondary (RAFT2 and 4), and tertiary radicals (RAFT 3) allowing evaluation of their effect on polymerization. RAFT5 was designed to produce polymeric materials with four‐arm architectures. RAFT1 showed comparable characteristics as conventional radical polymerization. RAFT2 and RAFT4 exhibited living/controlled polymerizations, owing to the combination of stable secondary radical species and incorporation of ethyl pyrrolidone moiety as the R and Z group, respectively. RAFT2 and RAFT5 gave first examples of random copolymers of NVP and VAc with linear and four‐arm star architectures, all exhibiting monomodal distributions and narrow dispersity. The four‐arm PVAc star was used as a macroCTA to synthesize amphiphilic four‐arm star PVAc‐block‐PNVP. The TEM investigation showed the formation of spherical micelles with an average diameter of about 60 nm. © 2014 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2015, 53, 775–786
Minimal Clinically Important Difference of Grip and Pinch Strength in Women With Thumb Carpometacarpal Osteoarthritis When Compared to Healthy Subjects
Authors: Villafañe Jorge Hugo , Valdes Kristin , Bertozzi Lucia , Negrini Stefano 
Published: December 2014

Abstract

Purpose:
The primary objective of this study was to compare grip and pinch strength between women with carpometacarpal (CMC) osteoarthritis (OA) between affected and unaffected sides of the body in patients or dominant and nondominant sides in healthy subjects. The secondary aim was to establish the cutoff value scores for the minimal clinically important difference (MCID) for grip strength, tip, and tripod pinch.

Design:
A prospective case-control study.

Methods:
One hundred ten women participated in the study. The CMC OA group consisted of 57 patients, and the control group consisted of 53 healthy subjects. Grip strength, tip, and tripod pinch were assessed bilaterally. The two-way analysis of variance (ANOVA) was conducted to determine the differences between sides of the body and between the groups.

Findings:
The post hoc analysis indicated that the patients in the CMC OA group indicated statistically significant lower scores on the grip and pinch strength (all, p < .001). The MCID from baseline score in this patient population was 0.84 kg for grip, 0.33 kg for tip, and 0.35 kg for tripod pinch for the affected right arm and 1.12 kg for grip, 0.23 kg for tip, and 0.30 kg for tripod pinch for the unaffected left side.

Conclusions:
Women with CMC OA have significantly decreased grip strength, tip, and tripod pinch as compared to their healthy counterparts and may experience functional consequences because of this limitation.

Clinical Relevance:
Our study established the MCID for grip and pinch strength for individuals with CMC OA and their healthy counterparts.
The influence of landform on the understory plant community in a temperate Beech forest in northern Iran
Authors: Fazlollahi Mohammadi Maryam , Jalali Seyed Gholamali , Kooch Yahya , Theodose Theresa A. 
Published: December 2014

AbstractUnderstanding the factors that determine the distribution of understory plants is important because they represent the largest component of temperate forest plant diversity. We examined the influence of topographic gradients on the distribution of understory plants in Mazandaran Province, northern Iran. Our objective was to determine how the topography of the landscape influenced the composition of understory plant species (cover, diversity, richness, and evenness). We investigated two catena landscape shapes (Λ and V), several different slope positions and their subsequent effects on the composition of the understory herb layer. We established 120 plots that spanned six catenas that varied in shape and slope position (i.e, summit, shoulder, back slope, foot slope and toe slope). We measured the composition of understory plant species populations and calculated diversity using several indices. We found that plant distribution and abundance was strongly related to both catena shape and slope position. Statistical analyses revealed that plant species diversity and richness varied significantly with slope position of the catena, but only diversity varied with catena shape. In addition, significant interactions were found for both diversity and richness. Neither shape nor slope position had a significant effect on evenness alone. We concluded that catena shape and slope position both influence plant distribution, abundance, and biodiversity of the herb layer in these forests by affecting both understory light intensity and soil factors. Our results suggest that the herb layer on Λ‐shaped catenas and V‐shaped landforms were mostly controlled by topography and soil features, respectively.
Parental attitude toward deviance as a predictor of delinquency: Making the connection via perception and cognition
Authors: Walters Glenn D. 
Published: December 2014

ABSTRACTThis study tested a core postulate of social cognitive theory: i.e., that perception precedes cognition in the development of behavior. Using data from four of the first five waves of the 1725‐member (918 males, 807 females) National Youth Survey (NYS), youth perception of parental attitude toward deviance and youth attitude toward deviance at Waves 2 and 3 were tested as possible mediators of the relationship between Wave 1 parental attitude toward deviance and self‐reported delinquency at Wave 5. The target chain was both significant and significantly stronger than the reverse chain and there was no evidence that age, race, or sex moderated this mediated relationship. These results support the presence of a chaining process in which proximal social, perceptual, and cognitive events link to distal behavioral outcomes like delinquency.
Argo and Zero Dark Thirty: Film, Government, and Audiences
Authors: Pautz Michelle C. 
Published: December 2014

ABSTRACTWith the prevalence and accessibility of film today, we must wonder how film affects its audience. In particular, how does film influence an audience’s perceptions of the government? Regardless of the content, research demonstrates that film has the power to shape perceptions of its moviegoers on a range of subjects. In this study, two recent films,ArgoandZero Dark Thirty, were chosen as case studies to explore how Hollywood portrays the intelligence community in film and shapes opinions about the government more broadly. This research found that about 25% of viewers of the two films changed their opinion about the government after watching one of the movies. Additionally, many of those changes are reflected in an improvement in the sentiments about the government and its institutions. This exploratory research provokes interesting discussions about the ability of film to influence the perceptions of an audience.
How “Proficient” Is Proficient? Bilingual Listeners' Recognition of English Words in Noise
Authors: Shi Lu-Feng 
Published: December 2014

Purpose
Shi (2011, 2013) obtained sensitivity/specificity measures of bilingual listeners' English and relative proficiency ratings as the predictor of English word recognition in quiet. The current study investigated how relative proficiency predicted word recognition in noise.

Method
Forty-two monolingual and 168 bilingual normal-hearing listeners were included. Bilingual listeners rated their proficiency in listening, speaking, and reading in English and in the other language using an 11-point scale. Listeners were presented with 50 English monosyllabic words in quiet at 45 dB HL and in multitalker babble with a signal-to-noise ratio of +6 and 0 dB.

Results
Data in quiet confirmed Shi's (2013) finding that relative proficiency with or without dominance predicted well whether bilinguals performed on par with the monolingual norm. Predicting the outcome was difficult for the 2 noise conditions. To identify bilinguals whose performance fell below the normative range, dominance per se or a combination of dominance and average relative proficiency rating yielded the best sensitivity/specificity and summary measures, including Youden's index.

Conclusion
Bilinguals' word recognition is more difficult to predict in noise than in quiet; however, proficiency and dominance variables can predict reasonably well whether bilinguals may perform at a monolingual normative level.
Tinnitus and Hearing Survey: A Screening Tool to Differentiate Bothersome Tinnitus From Hearing Difficulties
Authors: Henry James A. , Griest Susan , Zaugg Tara L. , Thielman Emily , Kaelin Christine , Galvez Gino , Carlson Kathleen F. 
Published: December 2014

Purpose
Individuals complaining of tinnitus often attribute hearing problems to the tinnitus. In such cases some (or all) of their reported “tinnitus distress” may in fact be caused by trouble communicating due to hearing problems. We developed the Tinnitus and Hearing Survey (THS) as a tool to rapidly differentiate hearing problems from tinnitus problems.

Method
For 2 of our research studies, we administered the THS twice (mean of 16.5 days between tests) to 67 participants who did not receive intervention. These data allow for measures of statistical validation of the THS.

Results

Reliability of the THS was good to excellent regarding internal consistency (α = .86–.94), test–retest reliability (
r
= .76–.83), and convergent validity between the Tinnitus Handicap Inventory (Newman, Jacobson, & Spitzer, 1996; Newman, Sandridge, & Jacobson, 1998) and the A (Tinnitus) subscale of the THS (
r
= .78). Factor analysis confirmed that the 2 subscales, A (Tinnitus) and B (Hearing), have strong internal structure, explaining 71.7% of the total variance, and low correlation with each other (
r
= .46), resulting in a small amount of shared variance (21%).

Conclusion
These results provide evidence that the THS is statistically validated and reliable for use in assisting patients and clinicians in quickly (and collaboratively) determining whether intervention for tinnitus is appropriate.
The chemistry of negotiation: Rhythmic, glycan-driven acidification in a symbiotic conversation
Authors: Schwartzman Julia A. , Koch Eric , Heath-Heckman Elizabeth A. C. , Zhou Lawrence , Kremer Natacha , McFall-Ngai Margaret J. , Ruby Edward G. 
Published: December 2014

SignificanceThe chemical dialog through which a host promotes long-term symbioses with particular microbial partners remains largely unexplored, especially within complex consortia like the human microbiota. Natural, monospecific associations, including that between bobtail squid andVibrio fischeri, have proved useful for discovering shared strategies, such as rhythmic microbial signaling and symbiosis-induced development, subsequently found in mammalian associations. Here, we demonstrate that symbiont metabolism is driven by a diel provision of a squid-derived glycan, resulting in tissue acidification. This event alters bacterial physiology, favoring the cyclic production of bioluminescence, the functional basis of the symbiosis. More generally, studies of this association can help reveal mechanisms by which other hosts modulate the chemistry of symbiosis to regulate microbial community function.
Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides
Authors: López-Vicario Cristina , Alcaraz-Quiles José , García-Alonso Verónica , Rius Bibiana , Hwang Sung H. , Titos Esther , Lopategi Aritz , Hammock Bruce D. , Arroyo Vicente , Clària Joan 
Published: December 2014

Significance
Our study demonstrates that stabilization of cytochrome P-450 epoxides derived from omega-3 polyunsaturated fatty acids through inhibition of the inactivating enzyme soluble epoxide hydrolase (sEH) exerts beneficial actions in counteracting metabolic disorders associated with obesity. In addition, our study sheds more light on the role of sEH in cellular homeostasis by providing evidence that omega-3 epoxides and sEH inhibition regulate autophagy and endoplasmic reticulum stress in insulin-sensitive tissues, especially the liver. Therefore, administration of a sEH inhibitor is a promising strategy to prevent obesity-related comorbidities.