bluuebunny/crossref_metadata_2025_split huggingface dataset:
Results of the Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) Trial: A Behavioral Weight Loss Intervention in Overweight or Obese Breast Cancer Survivors
Authors: Rock Cheryl L. , Flatt Shirley W. , Byers Tim E. , Colditz Graham A. , Demark-Wahnefried Wendy , Ganz Patricia A. , Wolin Kathleen Y. , Elias Anthony , Krontiras Helen , Liu Jingxia , Naughton Michael , Pakiz Bilgé , Parker Barbara A. , Sedjo Rebecca L. , Wyatt Holly 
Published: August 2015

Purpose Obesity increases risk for all-cause and breast cancer mortality and comorbidities in women who have been diagnosed and treated for breast cancer. The Exercise and Nutrition to Enhance Recovery and Good Health for You (ENERGY) study is the largest weight loss intervention trial among survivors of breast cancer to date. Methods In this multicenter trial, 692 overweight/obese women who were, on average, 2 years since primary treatment for early-stage breast cancer were randomly assigned to either a group-based behavioral intervention, supplemented with telephone counseling and tailored newsletters, to support weight loss or a less intensive control intervention and observed for 2 years. Weight and blood pressure were measured at 6, 12, 18, and 24 months. Longitudinal mixed models were used to analyze change over time. Results At 12 months, mean weight loss was 6.0% of initial weight in the intervention group and 1.5% in the control group (P < .001). At 24 months, mean weight loss in the intervention and control groups was 3.7% and 1.3%, respectively (P < .001). Favorable effects of the intervention on physical activity and blood pressure were observed. The weight loss intervention was more effective among women older than 55 years than among younger women. Conclusion A behavioral weight loss intervention can lead to clinically meaningful weight loss in overweight/obese survivors of breast cancer. These findings support the need to conduct additional studies to test methods that support sustained weight loss and to examine the potential benefit of intentional weight loss on breast cancer recurrence and survival.
High Doses of Antimetabolites Followed by High-Dose Sequential Chemoimmunotherapy and Autologous Stem-Cell Transplantation in Patients With Systemic B-Cell Lymphoma and Secondary CNS Involvement: Final Results of a Multicenter Phase II Trial
Authors: Ferreri Andrés J.M. , Donadoni Giovanni , Cabras Maria Giuseppina , Patti Caterina , Mian Michael , Zambello Renato , Tarella Corrado , Di Nicola Massimo , D'Arco Alfonso M. , Doa Gianluca , Bruno-Ventre Marta , Assanelli Andrea , Foppoli Marco , Citterio Giovanni , Fanni Alessandro , Mulè Antonino , Caligaris-Cappio Federico , Ciceri Fabio 
Published: August 2015

Purpose Treatment of secondary CNS dissemination in patients with aggressive lymphomas remains an important, unmet clinical need. Herein, we report the final results of a multicenter phase II trial addressing a new treatment for secondary CNS lymphoma based on encouraging experiences with high doses of antimetabolites in primary CNS lymphoma and with rituximab plus high-dose sequential chemoimmunotherapy (R-HDS) in relapsed aggressive lymphoma. Patients and Methods HIV-negative patients with aggressive B-cell lymphoma and secondary CNS involvement at diagnosis or relapse, age 18 to 70 years, and Eastern Cooperative Oncology Group performance status ≤ 3 were enrolled and treated with high-doses of methotrexate and cytarabine, followed by R-HDS (cyclophosphamide, cytarabine, and etoposide) supported by autologous stem-cell transplantation (ASCT). Treatment included eight doses of rituximab and four doses of intrathecal liposomal cytarabine. The primary end point was 2-year event-free survival; the planned accrual was 38 patients. Results Thirty-eight patients were enrolled; CNS disease was detected at presentation in 16 patients. Toxicity was usually hematologic and manageable, with grade 4 febrile neutropenia in 3% of delivered courses and grade 4 nonhematologic toxicity in 2% of delivered courses. Four patients died because of toxicity. Autologous stem cells were successfully collected in 24 (89%) of 27 patients (median, 10 × 106/kg); 20 patients underwent ASCT. Complete response was achieved in 24 patients (complete response rate, 63%; 95% CI, 48% to 78%). At a median follow-up of 48 months, 17 patients remained relapse free, with a 2-year event-free survival rate of 50% ± 8%. At 5 years, 16 patients were alive, with a 5-year overall survival rate of 41% ± 8% for the whole series and 68% ± 11% for patients who received transplantation. Systemic (extra-CNS) and/or meningeal disease did not affect outcome. Conclusion The combination of high doses of antimetabolites, R-HDS, and ASCT is feasible and effective in patients age 18 to 70 years old with secondary CNS lymphoma, and we propose it as a new standard therapeutic option.
Diacetylspermine Is a Novel Prediagnostic Serum Biomarker for Non–Small-Cell Lung Cancer and Has Additive Performance With Pro-Surfactant Protein B
Authors: Wikoff William R. , Hanash Samir , DeFelice Brian , Miyamoto Suzanne , Barnett Matt , Zhao Yang , Goodman Gary , Feng Ziding , Gandara David , Fiehn Oliver , Taguchi Ayumu 
Published: August 2015

Purpose We have investigated the potential of metabolomics to discover blood-based biomarkers relevant to lung cancer screening and early detection. An untargeted metabolomics approach was applied to identify biomarker candidates using prediagnostic sera from the Beta-Carotene and Retinol Efficacy Trial (CARET) study. Patients and Methods A liquid chromatography/mass spectrometry hydrophilic interaction method designed to profile a wide range of metabolites was applied to prediagnostic serum samples from CARET participants (current or former heavy smokers), consisting of 100 patients who subsequently developed non–small-cell lung cancer (NSCLC) and 199 matched controls. A separate aliquot was used to quantify levels of pro-surfactant protein B (pro-SFTPB), a previously established protein biomarker for NSCLC. On the basis of the results from the discovery set, blinded validation of a metabolite, identified as N1,N12-diacetylspermine (DAS), and pro-SFTPB was performed using an independent set of CARET prediagnostic sera from 108 patients with NSCLC and 216 matched controls. Results Serum DAS was elevated by 1.9-fold, demonstrating significant specificity and sensitivity in the discovery set for samples collected up to 6 months before diagnosis of NSCLC. In addition, DAS significantly complemented performance of pro-SFTPB in both the discovery and validations sets, with a combined area under the curve in the validation set of 0.808 (P < .001 v pro-SFTPB). Conclusion DAS is a novel serum metabolite with significant performance in prediagnostic NSCLC and has additive performance with pro-SFTPB.
Desaturase Activity Is Associated With Weight Status and Metabolic Risk Markers in Young Children
Authors: Wolters Maike , Schlenz Heike , Börnhorst Claudia , Risé Patrizia , Galli Claudio , Moreno Luis A. , Pala Valeria , Siani Alfonso , Veidebaum Toomas , Tornaritis Michael , Fraterman Arno , de Henauw Stefaan , Marild Staffan , Molnar Denes , Ahrens Wolfgang ,   on behalf of the IDEFICS consortium
Published: August 2015

Context:
Activity of delta-9, delta-6, and delta-5 desaturases (D9D, D6D, D5D) are associated with obesity, insulin resistance, and dyslipidemia.

Objective:
To investigate the association of estimated desaturase activities with weight status, insulin resistance, and dyslipidemia in children, cross-sectionally and longitudinally.

Design:
The IDEFICS (Identification and Prevention of Dietary- and Lifestyle-Induced Health Effects in Children and Infants) cohort study was used, with examinations at baseline (T0) and after 2 years (T1).

Setting and Participants:
Children aged 2 to less than 10 years from eight European countries were recruited in kindergartens/primary schools. Children with available data on fatty acids, outcome, and covariate information were included in the analyses.

Methods:
Whole blood fatty acids were analyzed in 2600 children at baseline. D9D (16:1n-7/16:0), D6D (20:3n-6/18:2n-6), and D5D (20:4n-6/20:3n-6) activities were estimated from product-precursor fatty acids ratios. Body mass index (BMI), Homeostatic Model Assessment index, and high-density lipoprotein cholesterol (HDL), and triglycerides (TG) served as outcomes for weight status, insulin resistance, and dyslipidemia, respectively. Linear and logistic regression and repeated measures models were used to assess the cross-sectional and longitudinal associations between desaturase activity and outcomes.

Results:
In the cross-sectional analysis, D9D and D6D were positively associated with BMI and TG z-scores and inversely with HDL z-scores. D5D was inversely associated with BMI and TG z-scores (ie, a D5D increase of 1 unit is associated with a BMI z-score decrease of 0.07 and a 28% lower odds ratio for TG ≥75th percentile). Longitudinally, similar associations were found for T0 desaturase activities with BMI and for T0 D6D with HDL at follow-up (T1). Baseline D6D and D5D were positively associated with the change of HDL z-score from T0 to T1, and D6D with the change of Homeostatic Model Assessment index z-score.

Conclusion:
Desaturase activities are associated with metabolic risk markers already in young children and appear to predict the metabolic risk.
Phylogeny and speciation in Saxifraga sect. Ciliatae (Saxifragaceae): Evidence from psbA‐trnH, trnL‐F and ITS sequences
Authors: Gao Qing-Bo , Li Yin-Hu , Gornall Richard J. , Zhang Zhuo-Xin , Zhang Fa-Qi , Xing Rui , Fu Peng-Cheng , Wang Jiu-Li , Liu Hai-Rui , Tian Zun-Zhe , Chen Shi-Long 
Published: August 2015

AbstractNearly half of the species in the large genus Saxifraga belong to Saxifraga sect. Ciliatae, a largely Sino‐Himalayan taxon. We report here that evidence from chloroplast DNA sequences (psbA‐trnH, trnL‐F) and from nuclear sequences (ITS) indicates that this section is monophyletic and composed of at least three main lineages, corresponding to (1) a clade made up of species from S. subsect. Gemmiparae, subsect. Cinerascentes, subsect. Flagellares and subsect. Hemisphaericae, in which the last three subsections are nested in the first; (2) a clade of species belonging to S. subsect. Rosulares (including S. subsect. Serpyllifoliae); and (3) a clade of species belonging to S. subsect. Hirculoideae. Species relationships in S. subsect. Rosulares and subsect. Hirculoideae are not well resolved. A molecular clock analysis indicates that the diversification of S. sect. Ciliatae into its three lineages dates from ca. 9.48 Ma, coinciding with orogenic events associated with one of the most important phases of uplift of the Qinghai‐Tibet Plateau. Extensive diversifications within S. subsect. Rosulares and subsect. Hirculoideae have been more recent (ca. 4.51 Ma and 2.12 Ma, respectively), again correlated with Qinghai‐Tibet Plateau uplift events and, in the case of S. subsect. Hirculoideae, have occurred at a rate comparable to that seen in the radiation of Hawaiian fruit flies.
Phylogeny, diversification and biogeographic implications of the eastern Mediterranean endemic genus Ricotia (Brassicaceae)
Authors: Özüdoğru Barış , Akaydın Galip , Erik Sadık , Al-Shehbaz Ihsan A. , Mummenhoff Klaus 
Published: August 2015

AbstractRicotia (Brassicaceae) is a genus of nine species endemic to the eastern Mediterranean region. Its phylogenetic relationships, monophyly, and tribal placement have not yet been adequately addressed. To achieve this, sequence data from the nuclear‐encoded ribosomal internal transcribed spacer (ITS) and chloroplast DNA (trnL‐F region) were analysed by parsimony, maximum likelihood, and Bayesian methods for 45 Ricotia accessions, representing all species and covering their entire distribution ranges, along with outgroups of selected members of main Brassicaceae lineages and tribes. The results clearly indicate, with high posterior probability/bootstrap support, that Ricotia is monophyletic and together with Lunaria should be assigned, with Biscutella and Megadenia, to tribe Biscutelleae. Divergence time estimations, using both a secondary calibration approach and published ITS substitution rates, indicate that the origin of Ricotia (crown group age, 9.2–11.3 Ma) predates the onset of the Mediterranean climate after the Messinian Salinity Crisis (5.9–5.3 Ma). We tentatively conclude that diversification within Ricotia was affected by climate changes during that geological epoch which had a great impact on the speciation history of the Mediterranean flora and fauna. Ancestral area reconstruction analyses revealed that Mediterranean Ricotia species arose in southwest Anatolia (likely Antalya region), whereas the origin of the genus remained unclear. Finally, a perennial life cycle appears to be ancestral in Ricotia, as revealed by an ancestral character state reconstruction analysis.
Revitalizing cinematic potential under authoritarian rule: Reporting from the second edition of the Human Rights Human Dignity International Film Festival (HRHDIFF), Yangon, Myanmar, 15–19 June 2014
Authors: Grøn Nis 
Published: August 2015

Abstract
The following is a report from the second edition of the Human Rights Film Festival in Yangon, Myanmar. Here we take a closer look at the realization of the newly established international film festival in Myanmar, and at how, despite the difficult socio-political conditions under which the organizers and local film-makers work, this festival is the result of courage and conviction as well as a belief in the power of cinema as a tool for social dialogue and change.
Worker, peasant, soldier … middle class? Class figures in Jia Zhangke’s 24 City
Authors: hultz Corey Kai Nelson 
Published: August 2015

Abstract
This article analyses the Maoist-class figures in Jia Zhangke’s 24 City (2008) and compares them with those found in Maoist-era visual culture. It examines how the films record the destruction and redevelopment of the social order, and the ways that the Maoist figures in the film have been made wretched or have disappeared. It argues, however, that the echo of their importance still remains, since the middleclass figures that appear in the film fuse previous Maoist elements with the contemporary success of economic reforms. They thus serve as a symbolic solution that combines the Maoist past with the Reform era present, therefore evoking the past to serve the present and the anticipated future.
Opinions of students participating in the pedagogical formation certificate program with regard to the profession and the program
Authors: Önder Emine , Tagay Özlem 
Published: August 2015

<p>In this research, the aim is to determine opinions of students participating in the pedagogical formation certificate program with regard to the teaching profession and the formation program. Study group of the research consists of 136 students who receive teaching formation education in the Faculty of Educational Sciences in Mehmet Akif Ersoy University as of fall term in the academic year of 2014-2015. In the research as a qualitative study, the phenomenological pattern is used. The data used in the study was collected by means of a question form developed by researchers and consisting of three parts. Research data was analyzed using the frequency analysis and the content analysis techniques. As a result of analyses, it was concluded that most of the participants considered teaching profession as a suitable profession for their personalities, and they thought that formation training was necessary for teaching profession and formation program brought teachers in the knowledge, skills and attitudes required for the teaching profession. In addition, it was also observed that the participants inserted their criticism of process and content of the program and gave different suggestions towards improving the quality of the program. </p>
Recovery Of Electrodic Powder From Spent Nickel-Metal Hydride Batteries (NiMH)
Authors: Shin S.M. , Shin D.J. , Jung G.J. , Kim Y.H. , Wang J.P. 
Published: August 2015

Abstract
This study was focused on recycling process newly proposed to recover electrodic powder enriched in nickel (Ni) and rare earth elements (La and Ce) from spent nickel-metal hydride batteries (NiMH). In addition, this new process was designed to prevent explosion of batteries during thermal treatment under inert atmosphere. Spent nickel metal hydride batteries were heated over range of 300°C to 600°C for 2 hours and each component was completely separated inside reactor after experiment. Electrodic powder was successfully recovered from bulk components containing several pieces of metals through sieving operation. The electrodic powder obtained was examined by X-ray diffraction (XRD) and energy dispersive X-ray spectroscopy (EDX) and image of the powder was taken by scanning electron microscopy (SEM). It was finally found that nickel and rare earth elements were mainly recovered to about 45 wt.% and 12 wt.% in electrodic powder, respectively.
Manufacturing And High Temperature Oxidation Properties Of Electro-Sprayed Fe-24.5% Cr-5%Al Powder Porous Metal
Authors: Lee Kee-Ahn , Oh Jae-Sung , Kong Young-Min , Kim Byoung-Kee 
Published: August 2015

Abstract
Fe-Cr-Al based Powder porous metals were manufactured using a new electro-spray process, and the microstructures and high-temperature oxidation properties were examined. The porous materials were obtained at different sintering temperatures (1350°C, 1400°C, 1450°C, and 1500°)C and with different pore sizes (500 μm, 450 μm, and 200 μm). High-temperature oxidation experiments (TGA, Thermal Gravimetry Analysis) were conducted for 24 hours at 1000°C in a 79% N2+ 21% O2, 100 mL/min. atmosphere. The Fe-Cr-Al powder porous metals manufactured through the electro-spray process showed more-excellent oxidation resistance as sintering temperature and pore size increased. In addition, the fact that the densities and surface areas of the abovementioned powder porous metals had the largest effects on the metal’s oxidation properties could be identified.
Atomistic Analysis Of Radiation-Induced Segregation In Ion-Irradiated Stainless Steel 316
Authors: Lee G.-G. , Jin H.-H. , Chang K. , Lee B.H. , Kwon J. 
Published: August 2015

Abstract
Stainless steel (SS) is a well-known material for the internal parts of nuclear power plants. It is known that these alloys exhibit radiation-induced segregation (RIS) at point defect sinks at moderate temperature, while in service. The RIS behavior of SS can be a potential problem by increasing the susceptibility to irradiation-assisted stress corrosion cracking. In this work, the RIS behavior of solute atoms at sinks in SS 316 irradiated with Fe4+ ions were characterized by atom probe tomography (APT). There were torus-shaped defects along with a depletion of Cr and enrichment of Ni and Si. These clusters are believed to be dislocation loops resulting from irradiation. The segregation of solutes was also observed for various defect shapes. These observations are consistent with other APT results from the literature. The composition of the clusters was analyzed quantitatively almost at the atomic scale. Despite the limitations of the experiments, the APT analysis was well suited for discovering the structure of irradiation defects and performing a quantitative analysis of RIS in irradiated specimens.
Self-Consolidation Mechanism Of Porous Ti-6Al-4V Implant Prototypes Produced By Electro-Discharge-Sintering Of Spherical Ti-6Al-4V Powders
Authors: Lee W.H. , Jo Y.J. , Kim Y.H. , Jo Y.H. , Seong J.G. , Van Tyne C.J. , Chang S.Y. 
Published: August 2015

Abstract
Electro-Discharge-Sintering (EDS) was employed to fabricate Ti-6Al-4V porous implant prototypes from atomized powders (100 – 150 μm), that were subjected to discharges of 0.75 to 2.0 kJ/0.7g-powder from 150, 300, and 450 μF capacitors. Both fully porous and porous-surfaced Ti-6Al-4V compacts with various solid core sizes were self-consolidated in less than 86 – 155 μsec. It is known that EDS can simultaneously produce the pinch pressure to squeeze and deform powder particles and the heat to weld them together. The formation of a solid core in these prototypes depends on the amounts of both the pinch pressure and heat generated during a discharge. The size of the solid core and the thickness of the porous layer can be successfully controlled by manipulating the discharge conditions such as input energy and capacitance.
Synthesis And Electrochemical Characteristics Of Mechanically Alloyed Anode Materials SnS2 For Li/SnS2 Cells
Authors: Hong J.H. , Liu X.J. , Park D.K. , Kim K.W. , Ahn H.J. , Ahn I.S. 
Published: August 2015

Abstract
With the increasing demand for efficient and economic energy storage, tin disulfide (SnS2), as one of the most attractive anode candidates for the next generation high-energy rechargeable Li-ion battery, have been paid more and more attention because of its high theoretical energy density and cost effectiveness. In this study, a new, simple and effective process, mechanical alloying (MA), has been developed for preparing fine anode material tin disulfides, in which ammonium chloride (AC), referred to as process control agents (PCAs), were used to prevent excessive cold-welding and accelerate the synthesis rates to some extent. Meanwhile, in order to decrease the mean size of SnS2 powder particles and improve the contact areas between the active materials, wet milling process was also conducted with normal hexane (NH) as a solvent PCA. The prepared powders were both characterized by X-ray diffraction, Field emission-scanning electron microscopeand particle size analyzer. Finally, electrochemical measurements for Li/SnS2 cells were takenat room temperature, using a two-electrode cell assembled in an argon-filled glove box and the electrolyte of 1M LiPF6 in a mixture of ethylene carbonate(EC)/dimethylcarbonate (DMC)/ethylene methyl carbonate (EMC) (volume ratio of 1:1:1).
Joining Of Green Body And Dense Substrate For Indium Tin Oxide Under Uniaxial Pressure In An Open Condition
Authors: Moon G.-S. , Chung T.-J. , Yang S.-H. , Hong G.-S. , Oh K.-S. 
Published: August 2015

Abstract
The green body and dense substrate of indium tin oxide was joined by uniaxially pressing at 0.3 MPa at 1300°C to test the restoring of the eroded part of transparent conducting oxide target. The green body was sintered to 98% of theoretical density under the suppression of shrinkage along the boundary below 5%. The boundary between two parts was free of pore but could be recognized from the difference in grain sizes. The joined part had the virtually same density with the substrate, but the grain size was less than one fifth compared with that of substrate.
Co Oxidation Properties Of Selective Dissoluted Metallic Glass Composites
Authors: Kim S.-Y. , Lee M.-H. , Kim T.-S. , Kim B.-S. 
Published: August 2015

Abstract
Porous metallic materials have been widely used in many fields including aerospace, atomic energy, electro chemistry and environmental protection. Their unique structures make them very useful as lightweight structural materials, fluid filters, porous electrodes and catalyst supports. In this study, we fabricated Ni-based porous metallic glasses having uniformly dispersed micro meter pores by the sequential processes of ball-milling and chemical dissolution method. We investigated the application of our porous metal supported for Pt catalyst. The oxidation test was performed in an atmosphere of 1% CO and 3% O2. Microstructure observation was performed by using a scanning electron microscope. Oxidation properties and BET (Brunauer, Emmett, and Teller) were analyzed to understand porous structure developments. The results indicated that CO Oxidation reaction was dependent on the specific surface area.