bluuebunny/crossref_metadata_2025_split huggingface dataset:
L'écolonomie au pays des Ch'tis. POCHECO : de l'enveloppe à l'écoveloppe ®
Authors: Cardinal Jacqueline 
Published: February 2014

En 1997, la société française POCHECO, de Forest-sur-Marque, qui fabrique des enveloppes de mise sous pli automatique, est au bord de la faillite. Son principal actionnaire a le choix : ou bien il ferme l’usine, ou bien il engage son fils comme président. Avec l’accord de son coactionnaire, il choisira la deuxième solution. Emmanuel Druon, qui prend alors la tête de l’entreprise, exige toutefois de pouvoir gérer celle-ci à sa façon. Et sa façon consiste à appliquer l’écolonomie, soit l’alliage de l’écologie et de l’économie. Il mettra en œuvre trois principes auxquels il tient fermement : la baisse de l’impact sur l’environnement, la baisse de la dangerosité et de la pénibilité du travail ainsi que l’amélioration de la productivité. Cet article relate de quelle manière le président s’y est pris pour rendre son entreprise à la fois prospère et respectueuse de l’environnement.
Pan-Bcl-2 Inhibitor, GX15-070 (Obatoclax), Decreases Human T Regulatory Lymphocytes while Preserving Effector T Lymphocytes: A Rationale for Its Use in Combination Immunotherapy
Authors: Kim Peter S. , Jochems Caroline , Grenga Italia , Donahue Renee N. , Tsang Kwong Y. , Gulley James L. , Schlom Jeffrey , Farsaci Benedetto 
Published: February 2014

AbstractBcl-2 inhibitors are currently being evaluated in clinical studies for treatment of patients with solid tumors and hematopoietic malignancies. In this study we explored the potential for combining the pan-Bcl-2 inhibitor GX15-070 (GX15; obatoclax) with immunotherapeutic modalities. We evaluated the in vitro effects of GX15 on human T cell subsets obtained from PBMCs in terms of activation, memory, and suppressive function. Our results indicated that in healthy-donor PBMCs, mature-activated T cells were more resistant to GX15 than early-activated T cells, and that GX15 preserved memory but not non-memory T cell populations. Furthermore, GX15 increased the apoptosis of regulatory T cells (Tregs), profoundly downregulated FOXP3 and CTLA-4 in a dose-dependent manner, and decreased their suppressive function. Treating PBMCs obtained from ovarian cancer patients with GX15 also resulted in increased CD8+:Treg and CD4+:Treg ratios. These results support preclinical studies in which mice vaccinated before treatment with GX15 showed the greatest reduction in metastatic lung tumors as a result of increased apoptotic resistance of mature CD8+ T cells and decreased Treg function brought about by GX15. Taken together, these findings suggest that when a Bcl-2 inhibitor is combined with active immunotherapy in humans, such as the use of a vaccine or immune checkpoint inhibitor, immunotherapy should precede administration of the Bcl-2 inhibitor to allow T cells to become mature, and thus resistant to the cytotoxic effects of the Bcl-2 inhibitor.
The DC-HIL/Syndecan-4 Pathway Regulates Autoimmune Responses through Myeloid-Derived Suppressor Cells
Authors: Chung Jin-Sung , Tamura Kyoichi , Akiyoshi Hideo , Cruz Ponciano D. , Ariizumi Kiyoshi 
Published: February 2014

AbstractHaving discovered that the dendritic cell (DC)–associated heparan sulfate proteoglycan–dependent integrin ligand (DC-HIL) receptor on APCs inhibits T cell activation by binding to syndecan-4 (SD-4) on T cells, we hypothesized that the DC-HIL/SD-4 pathway may regulate autoimmune responses. Using experimental autoimmune encephalomyelitis (EAE) as a disease model, we noted an increase in SD-4+ T cells in lymphoid organs of wild-type (WT) mice immunized for EAE. The autoimmune disease was also more severely induced (clinically, histologically, and immunophenotypically) in mice knocked out for SD-4 compared with WT cohorts. Moreover, infusion of SD-4−/− naive T cells during EAE induction into Rag2−/− mice also led to increased severity of EAE in these animals. Similar to SD-4 on T cells, DC-HIL expression was upregulated on myeloid cells during EAE induction, with CD11b+Gr-1+ myeloid-derived suppressor cells (MDSCs) as the most expanded population and most potent T cell suppressor among the myeloid cells examined. The critical role of DC-HIL was supported by DC-HIL gene deletion or anti–DC-HIL treatment, which abrogated T cell suppressor activity of MDSCs, and also by DC-HIL activation inducing MDSC expression of IFN-γ, NO, and reactive oxygen species. Akin to SD-4−/− mice, DC-HIL−/− mice manifested exacerbated EAE. Adoptive transfer of MDSCs from EAE-affected WT mice into DC-HIL−/− mice reduced EAE severity to the level of EAE-immunized WT mice, an outcome that was precluded by depleting DC-HIL+ cells from the infused MDSC preparation. Our findings indicate that the DC-HIL/SD-4 pathway regulates autoimmune responses by mediating the T cell suppressor function of MDSCs.
Critical Role of MicroRNA-155 in Herpes Simplex Encephalitis
Authors: Bhela Siddheshvar , Mulik Sachin , Reddy Pradeep B. J. , Richardson Raphael L. , Gimenez Fernanda , Rajasagi Naveen K. , Veiga-Parga Tamara , Osmand Alexander P. , Rouse Barry T. 
Published: February 2014

AbstractHSV infection of adult humans occasionally results in life-threatening herpes simplex encephalitis (HSE) for reasons that remain to be defined. An animal system that could prove useful to model HSE could be microRNA-155 knockout (miR-155KO) mice. Thus, we observe that mice with a deficiency of miR-155 are highly susceptible to HSE with a majority of animals (75–80%) experiencing development of HSE after ocular infection with HSV-1. The lesions appeared to primarily represent the destructive consequences of viral replication, and animals could be protected from HSE by acyclovir treatment provided 4 d after ocular infection. The miR-155KO animals were also more susceptible to development of zosteriform lesions, a reflection of viral replication and dissemination within the nervous system. One explanation for the heightened susceptibility to HSE and zosteriform lesions could be because miR-155KO animals develop diminished CD8 T cell responses when the numbers, functionality, and homing capacity of effector CD8 T cell responses were compared. Indeed, adoptive transfer of HSV-immune CD8 T cells to infected miR-155KO mice at 24 h postinfection provided protection from HSE. Deficiencies in CD8 T cell numbers and function also explained the observation that miR-155KO animals were less able than control animals to maintain HSV latency. To our knowledge, our observations may be the first to link miR-155 expression with increased susceptibility of the nervous system to virus infection.
Entrepreneurs Held Hostage: Hang-Ups at Travelhangar.Com
Authors: Ensign Prescott C. , Woods Anthony A. 
Published: February 2014

The Case Study section of the International Journal of Entrepreneurship and Innovation serves two purposes. First, the case studies presented are concerned with problematical issues that are pertinent to students of entrepreneurship. Thus they constitute appropriate teaching and learning vehicles on a variety of postgraduate and undergraduate programmes. Each case study is accompanied by a set of guidelines for the use of tutors. Second, it is envisaged that those engaged in entrepreneurial activities will find the cases both interesting and useful. This case addresses how students might actually proceed in starting their own Internet company. It is inevitable that many students will currently be thinking about their big idea that will reshape the Internet. A story from this business area is easy to relate to for most students, and discussion flows readily. The case revolves around the two founders' issues with their business as they move further away from the university setting. When the venture was created, they did all the work, including sales. As they moved on to careers, they found students to replace them on the sales front. As they slowly moved out of the day-to-day workings of the enterprise, a problem arose with their new key sales person – he was doing all the work and only getting a portion of the returns.
Physical modeling of tidal resonance in a submarine canyon
Authors: Le Souëf K. E. , Allen S. E. 
Published: February 2014

AbstractCurrent observations in submarine canyons poleward of 30° are usually dominated by the semidiurnal (M2) tidal frequency, which is superinertial at these latitudes. Observations from a submarine canyon at 44°N (the Gully, Nova Scotia) suggest that canyons can be dominated by the subinertial (K1) tidal frequency if length scales are correct for resonance of the K1 frequency. A model of the Gully was constructed in a tank on a rotating table and tidal currents generated to determine factors that influence resonance. Resonance curves were fit to measurements from the laboratory canyon for a range of stratifications, background rotation rates, and forcing amplitudes. Dense water was observed upwelling onto the continental shelf on either side of the laboratory canyon and traveled at least one canyon width along the shelf. Friction values measured in the laboratory were much higher than expected, probably due to upwelled water surging onto the shelf on each tidal cycle, similar to a tidal bore. By scaling observations from the laboratory to the ocean and assuming friction in the ocean is also affected by water traveling onto the shelf, a resonance curve for the ocean was created. Because of the broad resonance curve, the diurnal tide remains strong year round at the Gully, even as stratification at the shelf break changes. Dense water surging onto the shelf on tidal frequencies may affect friction and mixing at other nonresonant canyons.
Prediction of Relapse After Discontinuation of Biologic Agents by Ultrasonographic Assessment in Patients With Rheumatoid Arthritis in Clinical Remission: High Predictive Values of Total Gray‐Scale and Power Doppler Scores That Represent Residual Synovial Inflammation Before Discontinuation
Authors: Iwamoto Taro , Ikeda Kei , Hosokawa Junichi , Yamagata Mieko , Tanaka Shigeru , Norimoto Ayako , Sanayama Yoshie , Nakagomi Daiki , Takahashi Kentaro , Hirose Koichi , Sugiyama Takao , Sueishi Makoto , Nakajima Hiroshi 
Published: February 2014

ObjectiveThis prospective study aimed to determine whether the comprehensive ultrasonographic assessment of synovial inflammation predicts relapse after discontinuation of treatment with a biologic agent in patients with rheumatoid arthritis (RA) in clinical remission.MethodsRA patients in clinical remission (Disease Activity Score in 28 joints [DAS28] <2.6) receiving treatment with a biologic agent who agreed to discontinue the treatment were recruited. Patients underwent a comprehensive ultrasound scan on 134 synovial sites in 40 joints and were prospectively followed up for 6 months. Physicians who evaluated the patients during the study period were blinded to the baseline ultrasound findings.ResultsForty‐two patients receiving either a tumor necrosis factor antagonist or tocilizumab were enrolled. Using the optimal cutoff values determined by receiver operating characteristic curve analysis, relapse rates were significantly higher in patients whose total ultrasound scores at discontinuation were high than in those whose total ultrasound scores were low (P < 0.001 for both total gray‐scale and power Doppler scores), whereas the difference between high and low DAS28 was not statistically significant (P = 0.158 by log rank test). Positive and negative predictive values were 80.0% and 73.3% for the total gray‐scale score and 88.9% and 74.2% for the total power Doppler score, respectively.ConclusionIn RA patients in clinical remission receiving treatment with a biologic agent, residual synovial inflammation determined by comprehensive ultrasound assessment predicted relapse within a short term after discontinuation of the treatment. Our data provide a rationale and groundwork to conduct a large‐scale study for establishment of ultrasound‐based strategies to optimize the period of treatment with a biologic agent.
The Hedonic Price for Italian Red Wine: Do Chemical and Sensory Characteristics Matter?
Authors: Levaggi Rosella , Brentari Eugenio 
Published: February 2014

ABSTRACTIn this article, we study the main determinants of price for Italian red wine sold on the domestic market via the estimation of a hedonic price function for the period 2005–2009. For each bottle considered, our dataset contains several characteristics, such as the price by retail channel (price in supermarkets and in wine shops), label characteristics, chemical analysis and sensory and experts’ evaluations. The unique features of the dataset allow us to study the price formation in the different market segments.The analysis shows that in the large‐scale retail trade consumers value most what is written on the label, but only if it is a verifiable characteristic; label characteristics are also important in wine shops, but a selection process exists to enter this market. Finally, selling wine via both channels appears to be a winning strategy: it allows the price to be increased in the large‐scale retail trade, but it does not reduce the price in wine shops.
Synthesis of Substituted Pyrazoles from Vinylhydrozones via Bromoamination and Hydroamination with 2,2,6,6‐Tetramethylpiperidine‐1‐oxyl and N‐Bromosuccinimide
Authors: Sar Dinabandhu , Paul Rajesh , Sengoden Mani , Punniyamurthy Tharmalingam 
Published: February 2014

AbstractThe CH oxidative amination of (Z)‐1‐allylidene‐2‐arylhydrazines with 2,2,6,6‐tetramethylpiperidine‐1‐oxyl (TEMPO)/N‐bromosuccinimide (NBS) provides highly substituted pyrazoles with 100 % regioselectivity in moderate to good yields. These protocols are effective at room temperature and offer a route for the construction of the target five membered heterocycles.
Ultralight Mesoporous Magnetic Frameworks by Interfacial Assembly of Prussian Blue Nanocubes
Authors: Kong Biao , Tang Jing , Wu Zhangxiong , Wei Jing , Wu Hao , Wang Yongcheng , Zheng Gengfeng , Zhao Dongyuan 
Published: February 2014

AbstractA facile approach for the synthesis of ultralight iron oxide hierarchical structures with tailorable macro‐ and mesoporosity is reported. This method entails the growth of porous Prussian blue (PB) single crystals on the surface of a polyurethane sponge, followed by in situ thermal conversion of PB crystals into three‐dimensional mesoporous iron oxide (3DMI) architectures. Compared to previously reported ultralight materials, the 3DMI architectures possess hierarchical macro‐ and mesoporous frameworks with multiple advantageous features, including high surface area (ca. 117 m2 g−1) and ultralow density (6–11 mg cm−3). Furthermore, they can be synthesized on a kilogram scale. More importantly, these 3DMI structures exhibit superparamagnetism and tunable hydrophilicity/hydrophobicity, thus allowing for efficient multiphase interfacial adsorption and fast multiphase catalysis.
Effects of amino‐functionalized carbon nanotubes on the properties of amine‐terminated butadiene–acrylonitrile rubber‐toughened epoxy resins
Authors: Zhang Jusheng , Wang Yuting , Wang Xiaoshan , Ding Guowei , Pan Youqiang , Xie Hongfeng , Chen Qingmin , Cheng Rongshi 
Published: February 2014

ABSTRACTAmino‐functionalized multiwalled carbon nanotubes (MWCNT‐NH2s) as nanofillers were incorporated into diglycidyl ether of bisphenol A (DGEBA) toughened with amine‐terminated butadiene–acrylonitrile (ATBN). The curing kinetics, glass‐transition temperature (Tg), thermal stability, mechanical properties, and morphology of DGEBA/ATBN/MWCNT‐NH2 nanocomposites were investigated by differential scanning calorimetry (DSC), thermogravimetric analysis, a universal test machine, and scanning electron microscopy. DSC dynamic kinetic studies showed that the addition of MWCNT‐NH2s accelerated the curing reaction of the ATBN‐toughened epoxy resin. DSC results revealed that the Tg of the rubber‐toughened epoxy nanocomposites decreased nearly 10°C with 2 wt % MWCNT‐NH2s. The thermogravimetric results show that the addition of MWCNT‐NH2s enhanced the thermal stability of the ATBN‐toughened epoxy resin. The tensile strength, flexural strength, and flexural modulus of the DGEBA/ATBN/MWCNT‐NH2 nanocomposites increased increasing MWCNT‐NH2 contents, whereas the addition of the MWCNT‐NH2s slightly decreased the elongation at break of the rubber‐toughened epoxy. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40472.
Efficacy of Tocilizumab in Conventional Treatment–Refractory Adult‐Onset Still's Disease: Multicenter Retrospective Open‐Label Study of Thirty‐Four Patients
Authors: Ortiz‐Sanjuán Francisco , Blanco Ricardo , Calvo‐Rio Vanesa , Narvaez Javier , Rubio Romero Esteban , Olivé Alejandro , Castañeda Santos , Gallego Flores Adela , Hernández M. Victoria , Mata Cristina , Ros Vilamajo Inmaculada , Sifuentes Giraldo Walter Alberto , Caracuel Miguel A. , Freire Mercedes , Gómez Arango Catalina , Llobet José , Manrique Arija Sara , Marras Carlos , Moll‐Tuduri Concepción , Plasencia‐Rodriguez Chamaida , Roselló Rosa , Urruticoechea Ana , Velloso‐Feijoo Maria L. , del Blanco Jordi , González‐Vela M. Carmen , Rueda‐Gotor Javier , Pina Trinitario , Loricera Javier , González‐Gay Miguel A. 
Published: February 2014

ObjectiveAdult‐onset Still's disease (AOSD) is frequently refractory to standard therapy. Tocilizumab (TCZ) has demonstrated efficacy in single cases and in small series of patients with AOSD. The aim of this multicenter study was to assess the efficacy of TCZ in patients with AOSD refractory to conventional treatment.MethodsThis was a retrospective open‐label study of TCZ treatment in 34 patients with AOSD who had experienced an inadequate response to corticosteroids and at least 1 standard synthetic immunosuppressive drug and also, in many cases, biologic agents.ResultsThe mean ± SD age of the patients (8 men and 26 women) was 38.7 ± 16.1 years. The median duration of AOSD before TCZ was initiated was 4.2 years (interquartile range [IQR] 1–9 years). The initial dosages of intravenous TCZ were 8 mg/kg every 4 weeks in 22 patients, 4 mg/kg every 4 weeks in 2 patients, and 8 mg/kg every 2 weeks in 10 patients. TCZ treatment resulted in rapid and maintained improvement in both clinical and laboratory parameters. After 1 year of TCZ therapy, the incidence of joint manifestations had decreased from 97.1% at baseline to 32.4%, the incidence of both cutaneous manifestations and fever had decreased from 58.8% to 5.9%, and the incidence of lymphadenopathy had decreased from 29.4% to 0%. A dramatic reduction in laboratory markers of inflammation, including the C‐reactive protein level, the erythrocyte sedimentation rate, and the ferritin level, was achieved. The median dosage of prednisone was also reduced, from 13.8 mg/day (IQR 5–45) at the initiation of TCZ to 2.5 mg/day (IQR 0–30) at 12 months. After a median followup of 19 months (IQR 12–31 months), only 2 patients required permanent discontinuation of TCZ therapy because of severe infections.ConclusionTCZ treatment was associated with rapid and maintained clinical and laboratory improvement in patients with AOSD refractory to standard treatment. However, joint manifestations seem to be more refractory to treatment compared with systemic manifestations.
A long‐term study of the effects of antiviral therapy on survival of patients with HBV‐associated hepatocellular carcinoma (HCC) following local tumor ablation
Authors: Hann Hie‐Won , Coben Robert , Brown Daniel , Needleman Laurence , Rosato Ernest , Min Albert , Hann Richard S. , Park Kyong Bin , Dunn Stephen , DiMarino Anthony J. 
Published: February 2014

AbstractThe ultimate goal of antiviral therapy for chronic hepatitis B (CHB) is prevention of hepatocellular carcinoma (HCC). Earlier we reported favorable effects of antiviral therapy on survival of HCC patients following curative tumor ablation (Int J Cancer online 14 April 2010; doi: 10.1002/ijc.25382). It was the first observation made in the United States. We now report 12 year follow‐up of this patient group. CHB patients with no prior antiviral therapy with a single HCC (≤7 cm) were studied. All patients underwent local tumor ablation as their first option. Patients diagnosed before 1999 received no antiviral treatment while those diagnosed after 1999 received antiviral treatment. Survival between the treated and untreated groups was compared. Among 555 HCC patients seen at our clinic between 1991 and 2013, 25 subjects were eligible. Nine subjects (all male patients, median age 53 years [46–66]) did not receive antiviral therapy while 16 (14 male patients, median age 56 years [20–73]) received treatment. Between the two groups, there was no difference in their median tumor size and levels of alpha‐fetoprotein and albumin. However, the survival was significantly different (P = 0.001): the median survival of the untreated was 16 months (3–36 months) while that of the treated was 80 months (15–152 months). Fourteen of 16 treated patients are alive to date with two longest survivors alive for ≥151 months. In conclusion, concomitant antiviral therapy for CHB patients with HCC reduces and prevents new/recurrent tumor and improves survival. This novel treatment strategy offers an alternative to liver transplantation in patients with HBV‐associated HCC.
Life Cycle Cost Analysis as Decision Support Tool in Chemical Process Development
Authors: Sell Ina , Ott Denise , Kralisch Dana 
Published: February 2014

AbstractToday, it is common sense that environmentally benign chemical production processes are needed as the basis for future competitiveness and long‐term sustainability. Decision support in the development of such processes can be provided by life cycle assessment. New technologies, however, can be established only if they lead to cost‐efficient production processes as well. Life cycle costing analyses provide an appropriate methodological basis linking the cost‐side evaluation of alternative options during the process development with environmental decision criteria. The results of both methods can be combined in an eco‐portfolio. In summary, development of both ecologically and economically efficient processes can thus already be supported in the early design phase of the chemical processes.
CDK1 switches mitotic arrest to apoptosis by phosphorylating Bcl‐2/Bax family proteins during treatment with microtubule interfering agents
Authors: Zhou Lingli , Cai Xiaoling , Han Xueyao , Xu Naihan , Chang Donald C. 
Published: February 2014

AbstractMicrotubule interfering agents (MIAs), that can stabilise or depolymerise microtubules, are an important class of cancer chemotherapeutic drugs. They can lead to mitotic arrest and subsequent apoptosis. We demonstrate that cell cycle‐dependent kinase 1 (CDK1) is important in switching cells from mitotic arrest to apoptosis during MIAs treatment. Overexpression of non‐degradable cyclin B1 sustained CDK1 activation and mitotic arrest, followed by caspase‐3 dependent apoptosis. CDK1 is responsible for the phosphorylation of several pro‐ and anti‐apoptotic Bcl‐2 family proteins during MIAs treatment. CDK1‐mediated Bcl‐2 serine 70 phosphorylation enhances its pro‐apoptotic function, whereas CDK1‐mediated Bad serine 128 phosphorylation promotes apoptosis. Blockage of CDK1 activity with a specific pharmacological inhibitor suppresses Mcl‐1 phosphorylation, degradation and its anti‐apoptotic function. Therefore, the death of cancer cells under MIAs treatment was caused by imbalance between CDK1‐induced alterations in the pro‐apoptotic and anti‐apoptotic functions of phosphorylated Bcl‐2 family proteins.