bluuebunny/crossref_metadata_2025_split huggingface dataset:
Restauración de vehículos alterados por el método de conducción
Authors: Silva Masa Juan Andrés , Sánchez Polit Freddy Rodolfo , Chango Brito Cristhian Javier , Ulloa Pilliza Gabriela Carolina 
Published: July 2024

Introducción. La presente investigación tiene como objetivo determinar una nueva técnica de restauración de series alfanuméricas en vehículos alterados, considerando que el tratamiento térmico o por conducción constituye un conjunto de procesos técnicos destinados a modificar las propiedades físicas, mecánicas y/o químicas de los materiales, principalmente aceros y aleaciones metálicas. Esta técnica se enfoca en restablecer la superficie del metal a su estado original, ya que las moléculas se encuentran comprimidas debido a la acción abrasiva aplicada previamente. El método se aplica sobre la superficie cristalográfica para rellenar los vacíos y descomprimir el metal, lo que permite visualizar las series parcial o totalmente borradas o alteradas en una escala de grises. Es importante destacar que esta metodología, también conocida como pericia por inducción de calor, no es aplicable en motores de aluminio, ya que podría ocasionar la fusión del motor o daños en componentes aleatorios debido al exceso de calor directamente sobre las superficies. Objetivo. Explorar y analizar los desafíos, técnicas y tendencias emergentes en la restauración de vehículos que han sido alterados por tratamientos térmicos o condiciones extremas de conducción, con el fin de proporcionar una visión integral que sirva de guía tanto para entusiastas de la automoción como para profesionales del sector. Metodología. La metodología aplicable al siguiente estudio se llevó a cabo mediante la recopilación de información relevante sobre tratamientos térmicos y sus efectos en los materiales utilizados en la industria automotriz. De igual forma se utilizó como base el estudio de casos de vehículos que hayan sido alterados por tratamientos térmicos o condiciones extremas de conducción, culminando con el análisis exhaustivo de técnicas restaurativas empleadas por expertos en el campo. Resultados. El resultado final fue la técnica basada en el calor o la inducción de una llama de fuego aplicada directamente sobre una superficie de metal dulce, a una temperatura determinada, la misma que es aplicada únicamente sobre la superficie donde habitualmente vienen grabadas las series alfanuméricas. Conclusión. Es una técnica nueva de restauración en la aplicación de las pericias de identificación de grabados y marcas seriales de vehículos alterados sus series alfanuméricas, ya sean estas alteraciones por agentes abrasivos externos a las diferentes superficies o por borrados químicos. Área de estudio general: Criminalística. Área de estudio específica: Revenidos químicos
Data estimada de la edad biológica aplicando la odontología forense en seres humanos. Revisión bibliográfica
Authors: Lucas Benítez Liceth Gabriela , Vallejo González Pamela Sofía , Aguilar Mejía Melany Nicole , Salazar Yépez Marco Antonio 
Published: July 2024

Introducción. La odontología forense es una rama especifica de las ciencias odontología que se ocupa de la aplicación de los principios y métodos dentales para resolver cuestiones legales. La edad es una de las principales características biológicas manipuladas para identificar a los individuos, fundamentalmente en los casos en los que no se dispone de documentación. Objetivo. Analizar los diversos métodos existentes en las ciencias forenses que contribuyen a obtener una aproximación acertada de la edad biológica. Metodología. El enfoque de investigación será de carácter descriptivo, con un enfoque cualitativo mediante una revisión bibliográfica. Resultados. Después de aplicar los criterios de inclusión y exclusión, se estableció el análisis de 250 artículos, de los cuales se pudo identificar 53 como aptos para revisión bibliográfica. Conclusión. Después de la previa investigación se establece que existe un sin número de métodos forenses que nos contribuyen a obtener una aproximación de la edad biológica cada uno con sus diferentes parámetros establecidos entre los más importantes tenemos el método Demirjian, Willems, Al Qahtani, Gustafson, Kval, asimismo los métodos visuales y bioquímicos. Área de estudio general: Medicina. Área de estudio específica: Odontología. Tipo de estudio: Artículos originales.
STRATEGI PEMASARAN USAHA MIKRO KECIL MENENGAH DALAM MENINGKATKAN DAYA SAING (STUDI KASUS WARUNG KOPI DOTTORO JALAN TINUMBU MAKASSAR)
Authors: Najib Marhawati , Fuad M. Fikri Nur , Mustari  , Rahmatullah  , Tadampali Andi Caezar To 
Published: July 2024

Marketing strategies are essential to apply in all areas related to business. Without marketing, the business you run will not develop rapidly. This research aims to determine the marketing strategy carried out by the Dottoro coffee shop business to increase sales. This research is descriptive research using a qualitative approach. The informant was chosen deliberately, namely the owner of the Dottoro coffee shop. Data collection procedures used in research include observation, interviews, and documentation. The data obtained was analyzed using SWOT analysis. Based on the research results, show that the strategy implemented by the Dottoro coffee shop business in Jalan Tinumbu Makassar, South Sulawesi Province is in quadrant one, namely Aggressive (growth-oriented strategy), which is a very profitable situation with implementation through Marketing Strategy. The coordinates of point x are the IFAS strategy coordinates with a coordinate point obtained, namely 3.45. In contrast, the coordinates of point y are the coordinates of the EFAS strategy with a coordinate point obtained, namely 3.06. The strategy that needs to be improved in the coffee shop business is to maintain the reputation of the Dottoro coffee shop by serving local specialty coffee. The availability of raw materials will make it easier for the Dottoro Coffee Shop business to expand locations in strategic places.

Keywords: Coffee shop, marketing strategy, SWOT analysis, MSMEs
Penyuluhan Kesehatan tentang Cuci Tangan di SDN 11 Tanjung Gunung Bangka Tengah
Authors: Marleni Marleni , Megawati Megawati 
Published: July 2024

Mencuci tangan adalah proses menghilangkan kotoran dan debu dari kulit tangan secara mekanis menggunakan sabun dan air. Tangan merupakan vektor utama penyebaran kuman penyebab penyakit. Akibat kurangnya kebiasaan mencuci tangan, anak berisiko tinggi terkena diare dan penyakit pernafasan yang seringkali berujung pada kematian. Anak-anak di sekolah adalah kandidat terbaik untuk menerapkan nilai-nilai PHBS dan memiliki kapasitas untuk bertindak sebagai agen perubahan, mempromosikan PHBS di rumah, sekolah, dan masyarakat. Metode pelaksanaan penyuluhan tentang cuci tangan adalah dengan memperkenalkan materi cuci tangan kepada masyarakat. Peserta dari kegiatan penyuluhan ini adalah murid dan guru yang mendampingi. Tahapan dalam penyuluhan cuci tangan meliputi tahap mengidentifikasi masalah, tahap penyuluhan, dan tahap evaluasi. Data yang diperoleh dari hasil wawancara pada pihak sekolah SDN 11 Tanjung Gunung, didapatkan bahwa siswa di sekolah tersebut belum diberikan pengetahuan mengenai kebersihan cuci tangan yang benar sehingga mereka tidak bisa mencuci tangan dengan baik. Maka perlu dilaksanakan edukasi tentang 6 langkah mencuci tangan dengan sabun serta praktik langsung bagaimana cara mencuci tangan yang benar. Berdasarkan hasil dan pembahasan yang telah dijelaskan dapat disimpulkan bahwa tingkat pemahaman pada siswa dalam memahami dan mempraktekan gerakan 6 langkah cuci tangan yang ditetapkan oleh WHO cukup efektif dan mengalami peningkatan setelah dilakukan penyuluhan tersebut.
Edukasi Pencegahan Kekurangan Energi Kronik pada Remaja dalam Upaya Penurunan Stunting
Authors: Jaelani Sri , Sitawati Sitawati 
Published: July 2024

Kekurangan Energi Kronik (KEK) merupakan suatu kondisi dimana remaja mengalami kekurangan zat besi (kalori dan protein) yang berkepanjangan atau kronis. Menurut penyataan UNICEF penyebab terjadinya stunting adalah ketidakseimbangan nutrisi, berat badan lahir rendah dan riwayat penyakit apapun yang diderita ibu selama kehamilan, seperti kekurangan energi kronik. Banyak remaja putri menderita kekeurangan asupan energi dan protein. Rendahnya asupan zat mikro. Secara nasional prevalensi kekurangan energi kronis adalah 20,8% pada wanita usia subur sebanyak 6,8% pada wanita dengan berat bdan kurang pada usia 13 hingga 15 tahun dan 1,9% pada wanita sangat kurus. Edukasi Gizi merupakan suatu metode dan upaya untuk meningkatkan pengetahuan gizi dan perilaku makan untuk menciptakan pengetahuan dan sikap remaja terhadap gizi, semakin tinggi pengetahuan gizi makan semakin besar pula pengaruhnya terhadap sikap dan perilaku terhadap asupan makanan. Faktor-faktor yang dapat menyebabkan stunting ppada balitas sangat berkaitan antara yang satu dengan yang lainnya. Prevalensi kejadian stunting pada remaja disebabkan angka kekurangan energi kronik pada remaja masih tinggi. Peserta yang mengikuti kegitana sebanyak 40 orang. Dengan mengunakan media leafleat yang dibagikan kepada semua remaja yang mengikuti sosialisasi. Diharapkan setelah dilakukan kegiatan ini meningkatkan penegtahuan serta pemahamana remaja serta termotivasi untuk menjag kesehatan dengan selalu mengkonsumsi tablet penambah darah (TTD) dan mengkonsumsi makanan yang bergizi bertujuan mencegah terjadinya Kekurangan Energi Kronik pada remaja.
3D-printed Mg-incorporated PCL-based scaffolds improves rotator cuff tendon-bone healing through regulating macrophage polarization
Authors: Wang Tao , Yu Ziqing , Lin Shaozhang , Chen Zhaohuan , Jin Han , Liang Lin , Zhang Zhi-Yong 
Published: July 2024

Introduction: Rotator cuff tear (RCT) is a common shoulder injury impacting mobility and quality of life, while traditional surgeries often result in poor healing. Tissue engineering offers a promising solution, with poly (ε-caprolactone) (PCL) being favored due to its slow degradation, biocompatibility, and non-toxicity. However, PCL lacks sufficient compression resistance. Incorporating Mg, which promotes bone growth and has antibacterial effects, could enhance RCT repair.Methods: The Mg-incorporated PCL-based scaffolds were fabricated using a 3D printing technique. The scaffolds were incorporated with different percentages of Mg (0%, 5%, 10%, 15%, and 20%). The osteogenic activities and anti-inflammatory properties of the scaffolds were evaluated in vitro using human osteoblasts and macrophages. The tissue ingrowth and biocompatibility of the scaffolds were assessed in vivo using a rat model of RCT repair. The ability of the scaffolds to enhance macrophage polarization towards the M2 subtype and inhibit inflammation signaling activation was also investigated.Results: It was found that when incorporated with 10% Mg, PCL-based scaffolds exhibited the optimal bone repairing ability in vitro and in vivo. The in vitro experiments indicated that the successfully constructed 10 Mg/PCL scaffolds enhance osteogenic activities and anti-inflammatory properties. Besides, the in vivo studies demonstrated that 10 Mg/PCL scaffolds promoted tissue ingrowth and enhanced biocompatibility compared to the control PCL scaffolds. Furthermore, the 10 Mg/PCL scaffolds enhanced the macrophages’ ability to polarize towards the M2 subtype and inhibited inflammation signaling activation.Discussion: These findings suggest that 3D-printed Mg-incorporated PCL scaffolds have the potential to improve RCT by enhancing osteogenesis, reducing inflammation, and promoting macrophage polarization. The incorporation of 10% Mg into PCL-based scaffolds provided the optimal combination of properties for RCT repair augmentation. This study highlights the potential of tissue engineering approaches in improving the outcomes of RCT repair and provides a foundation for future clinical applications.
The impact of fetuin-A on predicting aortic arch calcification: secondary analysis of a community-based survey
Authors: Lin Yi-Hung , Lin Meng-Hung , Shi Chung-Sheng , Lin Yu-Sheng , Lin Chun-Liang , Yang Yao-Hsu , Liao Yu-San , Chen Mei-Yen , Tsai Ming-Horng , Lin Ming-Shyan 
Published: July 2024

IntroductionAtherosclerotic cardiovascular disease is associated with a high mortality rate due to vascular calcification. The role of fetuin-A in aortic arch calcification (AAC) is less well understood.MethodsAn analysis of secondary biomarkers was performed on 800 individuals from the biobank using the community database. AAC was defined by radiologists based on imaging. Multiple variables logical analysis was used for risk analysis.ResultsA total of 736 individual samples were collected based on age and gender. The average age is 65 ± 10 years, and half the population comprises men. In spite of similar body weight, renal function, and hepatic function, the AAC group had higher blood pressure and fetuin-A levels independently: systolic blood pressure (SBP) index ≥130 mmHg [adjusted odds ratio (aOR) 1.85, 95% confidence interval (CI) 1.34–2.57, p = 0.002] and fetuin-A (aOR 0.62, 95% CI 0.50–0.76, p &lt; 0.001). Moreover, it is evident that AAC can be predicted more accurately when combined with SBP ≥130 mmHg and a low fetuin-A level (&lt;358 μg/ml: aOR 5.39, 95% CI 3.21–9.08) compared with the reference.ConclusionLow fetuin-A levels are significantly correlated with AAC while there is an increased association between vascular calcification and coexisting hypertension.
Diabetic retinopathy incidence, predictors and its association with longitudinal fasting blood sugar level changes among diabetes mellitus patients in Ethiopia: joint model
Authors: Abuhay Habtamu Wagnew , Lakew Ayenew Molla , Wolde Haileab Fekadu , Mengistu Berhanu , Legesse Mandefro Tadesse , Yenit Melaku Kindie 
Published: July 2024

BackgroundDiabetes mellitus (DM) is a global public health problem characterized by an elevated blood glucose level. Monitoring blood sugar levels is vital for effective diabetes management and preventing complications. However, the association between longitudinal biomarkers and the incidence of diabetic complications is often overlooked. Therefore, this study aimed to assess the incidence of diabetic retinopathy, predictors, and association with longitudinal fasting blood sugar level changes among diabetes mellitus patients in Ethiopia.MethodsA multicenter retrospective follow-up study was carried out in referral hospitals in Amhara region, Ethiopia. A random sample of 462 newly diagnosed DM patients was selected. The proportional hazard assumption was checked for the survival sub-model, and for the longitudinal sub-model, the normality assumption was checked. Then the joint modeling with time-dependent lagged parameterizations was fitted. Model assumptions and comparisons were checked. Finally, the hazard ratio with a 95% confidence interval (CI) with a corresponding P-value&lt;0.05 was used to identify predictors.ResultsIn this study, Overall, 54 patients developed DR, and the incidence rate was 2.33 per 1000 person-months over the follow-up period, with a 95% CI of [1.78, 3.05]. Rural residence (AHR = 2.21, 95% CI: [1.21, 4.05]), hypertension co-morbidity (AHR = 3.01, 95% CI: [1.85, 6.53]), and longer duration of DM (&gt;5 years) (AHR = 2.28, 95% CI: [1.91, 5.15]) were important predictors for the incidence of DR. In addition, the incidence of DR was substantially correlated with the time-dependent lagged value of FBS change (AHR = 4.20, 95% CI [1.62, 10.85]).ConclusionsIn this study, the incidence of diabetic retinopathy was somewhat high when compared to prior similar studies in Ethiopia. A joint model of longitudinal fasting blood sugar level changes was significantly associated with an increased risk of DR. Besides, being rural residence, hypertension co-morbidity, and a longer duration of DM were significant predictors for the incidence of DR. Therefore, public awareness, an integrated care approach, and prioritizing glycemic control are highly recommended.
Intra- and postoperative relative angiotensin II deficiency in patients undergoing elective major abdominal surgery
Authors: Krenn Katharina , Höbart Petra , Adam Lukas , Riemann Gregor , Christiansen Finn , Domenig Oliver , Ullrich Roman 
Published: July 2024

IntroductionThe classical axis of the renin–angiotensin system (RAS) makes an important contribution to blood pressure regulation under general anesthesia via the vasopressor angiotensin II (Ang II). As part of the alternative RAS, angiotensin-converting enzyme 2 (ACE2) modulates the pro-inflammatory and fibrotic effects of Ang II by processing it into the organ-protective Ang 1–7, which is cleaved to Ang 1–5 by ACE. Although the levels of ACE2 may be associated with postoperative complications, alternative RAS metabolites have never been studied perioperatively. This study was designed to investigate the perioperative kinetics and balance of both RAS axes around major abdominal surgery.MethodsIn this observational cohort study, 35 patients undergoing elective major abdominal surgery were included. Blood sampling was performed before and after induction of anesthesia, at 1 h after skin incision, at the end of surgery, and on postoperative days (POD) 1, 3, and 7. The equilibrium concentrations of Ang I–IV, Ang 1–7, and Ang 1–5 in plasma were quantified using mass spectrometry. The plasma protein levels of ACE and ACE2 were measured with ELISA.ResultsSurgery caused a rapid, transient, and primarily renin-dependent activation of both RAS axes that returned to baseline on POD 1, followed by suppression. After induction, the Ang II/Ang I ratio persistently decreased, while the ACE levels started to increase on POD 1 (all p &lt; 0.01 versus before anesthesia). Conversely, the ACE2 levels increased on POD 3 and 7 (both p &lt; 0.001 versus before anesthesia), when the median Ang 1–7 concentrations were unquantifiably low.DiscussionThe postoperative elevation of ACE2 may prolong the decrease of the Ang II/Ang I ratio through the increased processing of Ang II. Further clarification of the intraoperative factors leading to relative Ang II deficiency and the sources of postoperatively elevated ACE2 is warranted.
The efficacy and safety of chidamide in combination with etoposide and glucocorticoids for the treatment of hemophagocytic lymphohistiocytosis in adult patients: an open-label, single-center study
Authors: Hu Junxia , Wang Jingshi , Wang Zhao 
Published: July 2024

BackgroundHemophagocytic lymphohistiocytosis (HLH) is a life-threatening condition characterized by hyperinflammation and organ failure, with a high mortality rate. Current first-line treatments for adult patients have limited efficacy and significant toxicity. The novel selective histone deacetylase inhibitor (HDACi), chidamide, has shown promise in preclinical studies for the potential treatment of HLH.MethodsAn open-label, single-center study was conducted to evaluate the efficacy and safety of chidamide in combination with etoposide and glucocorticoids for the treatment of HLH in adult patients. Seventeen patients who fulfilled at least five of the eight HLH-2004 criteria were enrolled and treated with the combination therapy. The primary outcome was overall response rate (ORR), and secondary outcomes included survival, safety and tolerability, and changes in laboratory indicators.ResultsA total of 17 HLH patients who met the inclusion criteria were enrolled in this study, with a male to female ratio of 1.8:1. The age range at enrollment was 31 to 71 years old, with a median age of 52 years old. The ORR was 76.5% (13/17 patients), with a complete response (CR) rate of 17.6% (3/17 patients) and a partial response (PR) rate of 58.8% (10/17 patients). The median overall survival (OS) was not achieved, with OS at 6 months and 12 months being 81% and 65%, respectively. The median progression free survival (PFS) was not achieved, with PFS at 6 months and 12 months being 68% and 55%, respectively. Hematologic toxicities is the most common. Safety profile was favorable, with very few cases of grade 3/4 toxicities observed. The results showed that the levels of sCD25, platelets, aspartate aminotransferase, lactate dehydrogenase, and albumin in these patients were significantly improved 3 weeks after treatment.ConclusionThe addition of chidamide to etoposide and glucocorticoids may be a promising new treatment option for patients with HLH, with a high ORR, manageable safety profile, and significant improvement in laboratory indicators. Further research is needed to confirm these findings and determine the optimal dosing and duration of therapy.
Immunomodulatory effect of PLGA-encapsulated mesenchymal stem cells-derived exosomes for the treatment of allergic rhinitis
Authors: Shahzad Khawar Ali , Wang Zhao , Li Xuran , Li Jiaojiao , Xu Maoxiang , Tan Fei 
Published: July 2024

IntroductionAllergic rhinitis (AR) is an upper airway inflammatory disease of the nasal mucosa. Conventional treatments such as symptomatic pharmacotherapy and allergen-specific immunotherapy have considerable limitations and drawbacks. As an emerging therapy with regenerative potential and immunomodulatory effect, mesenchymal stem cell-derived exosomes (MSC-Exos) have recently been trialed for the treatment of various inflammatory and autoimmune diseases.MethodsIn order to achieve sustained and protected release of MSC-Exos for intranasal administration, we fabricated Poly(lactic-co-glycolic acid) (PLGA) micro and nanoparticles-encapsulated MSC-Exos (PLGA-Exos) using mechanical double emulsion for local treatment of AR. Preclinical in vivo imaging, ELISA, qPCR, flow cytometry, immunohistochemical staining, and multiomics sequencing were used for phenotypic and mechanistic evaluation of the therapeutic effect of PLGA-Exos in vitro and in vivo.ResultsThe results showed that our PLGA platform could efficiently encapsulate and release the exosomes in a sustained manner. At protein level, PLGA-Exos treatment upregulated IL-2, IL-10 and IFN-γ, and downregulated IL-4, IL-17 and antigen-specific IgE in ovalbumin (OVA)-induced AR mice. At cellular level, exosomes treatment reduced Th2 cells, increased Tregs, and reestablished Th1/Th2 balance. At tissue level, PLGA-Exos significantly attenuated the infiltration of immune cells (e.g., eosinophils and goblet cells) in nasal mucosa. Finally, multiomics analysis discovered several signaling cascades, e.g., peroxisome proliferator-activated receptor (PPAR) pathway and glycolysis pathway, that might mechanistically support the immunomodulatory effect of PLGA-Exos.DiscussionFor the first time, we present a biomaterial-facilitated local delivery system for stem cell-derived exosomes as a novel and promising strategy for AR treatment.