bluuebunny/crossref_metadata_2025_split huggingface dataset:
MUM, a maternal unknown message, inhibits early establishment of the medio-lateral axis in the embryo of the kelp Saccharina latissima
Authors: Boscq Samuel , Billoud Bernard , Theodorou Ioannis , Joemmanbaks Tanweer , Dufourt Tanguy , Charrier Bénédicte 
Published: August 2024

ABSTRACT
Brown algae are multicellular photosynthetic organisms that have evolved independently of plants and other algae. Here, we have studied the determinism of body axis formation in the kelp Saccharina latissima. After microdissection of the embryo, we show that the stalk, an empty cell that retains the embryo on the maternal tissue, represses longitudinal cell divisions in the early embryo, thereby reinforcing the establishment of the initial apico-basal axis. In addition, it promotes cell growth and controls cell shape and arrangement in the flat oblong embryo composed of cells aligned in rows and columns. Although the stalk persists for several weeks until the embryo reaches at least 500 cells, proper embryogenesis requires connection to maternal tissue only during the first 4 days after fertilisation, i.e. before the embryo reaches the 8-cell stage. Transplantation experiments indicate that the maternal signal is not diffused in seawater, but requires contact between the embryo and the maternal tissue. This first global quantitative study of brown algal embryogenesis highlights the role of MUM, an unknown maternal message, in the control of growth axes and tissue patterning in kelp embryos.
UNC-30/PITX coordinates neurotransmitter identity with postsynaptic GABA receptor clustering
Authors: Correa Edgar , Mialon Morgane , Cizeron Mélissa , Bessereau Jean-Louis , Pinan-Lucarre Berangere , Kratsios Paschalis 
Published: August 2024

ABSTRACT
Terminal selectors are transcription factors that control neuronal identity by regulating expression of key effector molecules, such as neurotransmitter biosynthesis proteins and ion channels. Whether and how terminal selectors control neuronal connectivity is poorly understood. Here, we report that UNC-30 (PITX2/3), the terminal selector of GABA nerve cord motor neurons in Caenorhabditis elegans, is required for neurotransmitter receptor clustering, a hallmark of postsynaptic differentiation. Animals lacking unc-30 or madd-4B, the short isoform of the motor neuron-secreted synapse organizer madd-4 (punctin/ADAMTSL), display severe GABA receptor type A (GABAAR) clustering defects in postsynaptic muscle cells. Mechanistically, UNC-30 acts directly to induce and maintain transcription of madd-4B and GABA biosynthesis genes (e.g. unc-25/GAD, unc-47/VGAT). Hence, UNC-30 controls GABAA receptor clustering in postsynaptic muscle cells and GABA biosynthesis in presynaptic cells, transcriptionally coordinating two crucial processes for GABA neurotransmission. Further, we uncover multiple target genes and a dual role for UNC-30 as both an activator and a repressor of gene transcription. Our findings on UNC-30 function may contribute to our molecular understanding of human conditions, such as Axenfeld–Rieger syndrome, caused by PITX2 and PITX3 gene variants.
Development of sound production in Danionella cerebrum
Authors: Groneberg Antonia H. , Dressler Lena E. , Kadobianskyi Mykola , Müller Julie , Judkewitz Benjamin 
Published: August 2024

ABSTRACT
Acoustic signalling, integral to intraspecific communication and reproductive behaviour, undergoes notable changes during an animal's ontogenetic development. The onset and progression of this maturation in fish remains poorly understood. Here, we investigated the ontogeny of acoustic communication in the miniature teleost Danionella cerebrum, one of the smallest known vertebrates and an emerging model organism. Its adult males produce audible clicks that appear in sequences with a repetition rate of ∼60 or ∼120 Hz, caused by consecutive unilateral or alternating bilateral compressions of the swim bladder. To investigate the maturation of this ability, we performed long-term sound recordings and morphological studies of the sound production apparatus in D. cerebrum throughout its ontogenetic development. We found that fish start producing clicks during the second month of their lives and continually increase their abundance and structured repetition over the course of the following 1 to 2 months. The sound production machinery, including specialised bone and cartilage structures, starts to form in males after approximately 4 weeks and prior to reaching sexual maturity. Although clicks increase in amplitude as animals mature, click repetition rates of 60 and 120 Hz are stable throughout development. This suggests fully mature pattern generation in juvenile males, yet a continued development of the drumming apparatus capable of creating louder sounds.
Multi-parameter to single parameter: a systematic review of wearable sensor sensitivity in seizure detection
Authors: Imzilene Ayoub , Lansi Ayoub , Emidar Abderahman 
Published: August 2024

Objective: This systematic review evaluates the effectiveness of multi-parametric and single-parameter wearable sensors in seizure detection – a vital aspect of neurological research focused on improving epilepsy management. Methods: The authors conducted a comprehensive literature search up to 1 July 2023 across PubMed, Scopus, ScienceDirect and IEEE Xplore. The inclusion criteria were studies on human subjects, in English, reporting seizure detection sensitivity using wearable systems. Quality assessment was performed using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool. Results: Out of 29 initial records, 8 studies involving 641 participants were included. Multi-parameter systems generally exhibited higher sensitivities, achieving up to 100% accuracy in certain settings. Single-parameter systems also proved effective. A meta-analysis, excluding studies with small sample sizes, was conducted, with confidence intervals calculated for most studies. Significance: This review highlights the potential of wearable sensors in enhancing seizure monitoring. While multi-parameter systems demonstrate superior sensitivities, single-parameter systems also show significant merits. The findings advocate for further large-scale research to validate these preliminary results and to explore the combined use of diverse sensors in seizure detection.
Recurrent acute pancreatitis as an initial presentation of primary hyperparathyroidism: A case report
Authors: Karim Masood M , Raza Hira , Parkash Om 
Published: August 2024

BACKGROUND
With 4.9 to 35 instances per 100000 cases, hyperparathyroidism is one of the rarest causes of acute pancreatitis. The major cause of primary hyperparathyroidism is a parathyroid adenoma, which can manifest clinically in various ways.
CASE SUMMARY
We discuss the unusual case of a 13-year-old boy with recurrent pancreatitis as the initial presentation of primary hyperparathyroidism. The cause of his recurrent pancreatitis remained unknown, and the patient had multiple admissions with acute pancreatitis over 3 years. His diagnosis was delayed due to the initial normal levels of parathyroid hormone, which were later reported elevated in a subsequent episode where ultrasound neck and thyroid scintigraphy revealed a parathyroid adenoma as the underlying cause. After the diagnosis was made, he underwent surgical resection of the adenoma.
CONCLUSION
This case study stresses the importance of considering uncommon causes for recurrent pancreatitis.
High performance visible spectral polarizer using a double-layer alternating metal grating and metamaterial substrate
Authors: Zhao Jiangting , Zhang Xiaoyu , Li Shoupeng , Yang Yandong 
Published: August 2024

A polarizer is a crucial component in polarization imaging technology. In practical applications, an excellent polarizer can significantly improve optical imaging quality, target detection ability, and the reliability of polarization imaging systems. To address the problems of high cost, difficult preparation, low transmittance, and extinction ratio, which are found in existing polarizers, this paper proposes a high performance visible spectral polarizer, where a double-layer alternating metal subwavelength grating is adopted, referred to as DAMG-Polarizer. The polarizer consists of a metamaterial substrate, which is covered with subwavelength metal gratings on its upper and lower surfaces. The simulation results demonstrate that the transverse magnetic (TM) transmittance of the polarizer ranges from 55.5% to 75.8% in the 350–800 nm visible wavelength region, with an average extinction ratio (ER) of 74.6 dB, and a maximum of 85 dB. Additionally, the polarizer has good process tolerance and exhibits less dependence on the incident angle. Compared to the existing metal grating polarizers, the proposed polarizer has superior performance and achieves high transmittance and a high extinction ratio simultaneously.
Public perception on face mask wearing during COVID-19 pandemic in Malaysia: A cross sectional study
Authors: Yusof Muhammad Zubir , Fadzil Nur Faza Zinnirah , Kamaruzi Nik Nur Niska Azlin , Ayazi Maya Syazana Syamimi 
Published: August 2024

Introduction
Since the emergence of COVID-19, the Malaysian government has made wearing a face mask in public mandatory since August 1, 2020, as an effort by the government to control the transmission of COVID-19. However, Malaysians’ willingness to wear face masks in public is unknown.

Objective
Thus, this study aimed to evaluate their perception of face mask wearing during COVID-19 and its contributing factors.

Methodology
A total of 1024 respondents, aged ≥ 18 years, participated in this online cross-sectional survey from October 2021 to December 2021. The Face Mask Perception Scale (FMPS) was used to measure their perceptions.

Results
Most of the respondents perceived wearing a face mask as uncomfortable. Our findings also revealed statistically significant differences and a small effect (f2 = 0.04) in which respondents who were concerned about being infected by the virus perceived face mask wearing appearance positively (B = - 0.09 units of log-transformed, 95% CI = - 0.15, - 0.04), whereas married respondents perceived it negatively (B = 0.07 units of log-transformed, 95% CI = 0.03, 0.09). There were no statistically significant differences in other domains of FMPS.

Conclusion
In conclusion, discomfort was a major complaint. Marital status and fear of COVID-19 infection affected their perceptions. The public health implications of these findings highlight the importance of addressing discomfort and societal perceptions, particularly those influenced by factors such as marital status and COVID-19 experience, to promote widespread acceptance and consistent usage of face masks, which is crucial in mitigating the spread of COVID-19.
Bidirectional gated recurrent unit network model can generate future visual field with variable number of input elements
Authors: Lee Joohwang , Park Keunheung , Kim Hwayeong , Moon Sangwoo , Kim Junglim , Jin Sangwook , Lee Seunguk , Lee Jiwoong 
Published: August 2024

Purpose
This study aimed to predict future visual field tests using a bidirectional gated recurrent unit (Bi-GRU) and assess its performance based on the number of input visual field tests and the prediction time interval.

Materials and methods
This study included patients who underwent visual field tests at least four times at five university hospitals between June 2004 and April 2022. All data were accessed in October 2022 for research purposes. In total, 23,517 eyes with 185,858 visual field tests were used as the training dataset, and 1,053 eyes with 9,459 visual field tests were used as the test dataset. The Bi-GRU architecture was designed to take a variable number of visual field tests, ranging from 3 to 80, as input and predict visual field tests at the desired arbitrary time point. It generated the mean deviation (MD), pattern standard deviation (PSD), Visual Field Index (VFI), and total deviation value (TDV) for 54 test points. To analyze the model performance, the mean absolute error between the actual and predicted values was calculated and analyzed for glaucoma severity, number of input visual field tests, and prediction time interval.

Results
The prediction errors of the Bi-GRU model for MD, PSD, VFI, and TDV ranged from 1.20 to 1.68 dB, 0.95 to 1.16 dB, 3.64 to 4.51%, and 2.13 to 2.60 dB, respectively, depending on the number of input visual field tests. Prediction errors tended to increase as the prediction time interval increased; however, the difference was not statistically significant. As the severity of glaucoma worsened, the prediction errors significantly increased.

Conclusion
In clinical practice, the Bi-GRU model can predict future visual field tests at the desired time points using three or more previous visual field tests.
The impact of patient engagement on patient safety in care transitions after cancer treatment: Protocol for a systematic review and meta-analysis
Authors: Brust Larissa , Schmidt-Wolf Ingo , Weigl Matthias 
Published: August 2024

BackgroundTransitions of care after cancer treatment pose a major challenge for patient safety as adverse events and unplanned healthcare utilization occur frequently. At this point, patient and family engagement (PFE) is particularly valuable since patients and their families experience various challenges along this pathway, such as changing roles and recurrent needs to navigate across structural gaps between different services. However, there is currently a lack of evidence on the impact of PFE on patient safety in transitions after cancer treatment.ObjectiveTo systematically review and synthesize evidence on effects of different PFE interventions on patient safety in the transition of care after cancer treatment.MethodsThis protocol for a systematic review with meta-analysis follows PRISMA-P guidelines. A comprehensive database search will be conducted in MEDLINE, EMBASE, CENTRAL, CINAHL, and APA PsycInfo. Trial registries and grey literature will be searched, forward and backward citation tracking will be performed. Trials with prospective, longitudinal, interventional study designs will be included if they evaluate PFE interventions on patient safety outcomes (primary outcomes: healthcare utilization, patient harm, adherence, patient experience; secondary: quality of life, distress); eligible studies need to survey patients with any oncological disease during or after transition following cancer treatment. Results will be synthesized narratively and meta-analytically using a random-effects model. Risk of bias will be assessed using the Cochrane RoB-2 and revised JBI critical appraisal tool. The certainty of evidence will be judged according to the GRADE approach.DiscussionRobust evidence of effectiveness is needed to establish PFE interventions for patient safety in care transitions for oncological patients. This review will allow evidence-based conclusions about types and effects of different PFE interventions for transitional safety in oncology care and inform stakeholders in designing sustainable PFE activities.Trial registrationPROSPERO (CRD42024546938), OSF (doi.org/10.17605/OSF.IO/9XAMU).
The synergy of depression and flourishing/languishing on suicidal thoughts and behaviors: Findings from a national sample of emerging adult students in higher education in the United States
Authors: Oh Hans , Jacob Louis , Soffer-Dudek Nirit , Shin Jae Il , Smith Lee , Besecker Megan , Leaune Edouard , Pickering Trevor A. 
Published: August 2024

Background
Suicide is a leading cause of death among students in higher education, driven in large part by mental illness, but also mental wellness. Relatively few studies have examined the extent to which depression and flourishing/languishing interact in relation to suicidal thoughts and behaviors.

Methods
We analyzed data from the Healthy Minds Study (2020–2021; emerging adult students aged 18–29; N = 101,435), and calculated interaction contrast ratios to estimate the interaction between depression and flourishing/languishing on suicidal thoughts and behaviors, using an additive scale, adjusting for age, gender, race/ethnicity, and food insecurity.

Results
When compared with students who were flourishing without depression, the students who were languishing without depression, and the students who were depressed but still flourishing had significantly greater odds of suicidal thoughts and behaviors. However, students who were depressed and languishing had the greatest odds, exceeding the sum of the individual effects.

Conclusion
The interaction of depression and flourishing/languishing produced a synergy that increased odds of suicidal thoughts and behaviors. Flourishing interventions may prove to be an effective strategy for universal suicide prevention.
Preclinical and clinical evaluation through serial colonoscopic evaluation of neratinib‐induced diarrhea in HER2‐positive breast cancer—A pilot study
Authors: Bowen Joanne , Braga Sofia , Zotto Valeria Dal , Finnie John , DiPrimeo Daniel , Cooke Blaire , Bischof Georg F. , Wong Alvin , Di Palma Jack A. 
Published: August 2024

AbstractThe irreversible pan‐HER tyrosine kinase inhibitor neratinib is approved for patients with HER2‐positive, early‐stage and metastatic breast cancer (BC). Neratinib‐associated diarrhea is the most common reason for early discontinuation. Preclinical studies identified mechanisms of neratinib‐induced diarrhea and rationale for prophylactic and preventive measures. We studied effects of neratinib on rat intestines and conducted a phase 2 study of colon pathogenesis in patients with HER2‐positive BC treated with neratinib (NCT04366713). Colon samples from female albino Wistar rats receiving neratinib or vehicle were examined for histopathological changes. Patients with HER2‐positive BC received neratinib 240 mg once daily for up to 1 year. Colonoscopy biopsies were collected at baseline and at Day 28 to identify changes consistent with rat pathologies. Rat colons were markedly altered in appearance, with similar short circuit currents (Isc) and responses to carbachol and forskolin. Mucosal barrier loss and/or significant increase in secretory propensity in neratinib‐ versus control‐treated animals were not seen. Two of four endpoint‐evaluable patients presented with mild pathological changes, largely comparable with the rat model. Preclinical evidence supports an inflammatory component of neratinib‐induced diarrhea without mucosal barrier function loss. Colonoscopy findings in patients with BC indicate mild or no pathological changes in the colon due to neratinib treatment.
Exercise‐induced appetite suppression: An update on potential mechanisms
Authors: McCarthy Seth F. , Tucker Jessica A. L. , Hazell Tom J. 
Published: August 2024

AbstractThe first systematic reviews of the effects of exercise on appetite‐regulation and energy intake demonstrated changes in appetite‐regulating hormones consistent with appetite suppression and decreases in subsequent relative energy intake over a decade ago. More recently, an intensity‐dependent effect and several potential mechanisms were proposed, and this review aims to highlight advances in this field. While exercise‐induced appetite suppression clearly involves acylated ghrelin, glucagon‐like peptide‐1 may also be involved, though recent evidence suggests peptide tyrosine tyrosine may not be relevant. Changes in subjective appetite perceptions and energy intake continue to be equivocal, though these results are likely due to small sample sizes and methodological inconsistencies. Of the proposed mechanisms responsible for exercise‐induced appetite suppression, lactate has garnered the most support through in vitro and in vivo rodent studies as well as a growing amount of work in humans. Other potential modulators of exercise‐induced appetite suppression may include sex hormones, growth‐differentiation factor 15, Lac‐Phe, brain‐derived neurotrophic factor, and asprosin. Research should focus on the mechanisms responsible for the changes and consider these other modulators (i.e., myokines/exerkines) of appetite to improve our understanding of the role of exercise on appetite regulation.
Neues Bauen für den neuen Menschen?
Authors: Düchs Martin , Wabel Thomas 
Published: August 2024

Zusammenfassung
Gibt es Bauten, die den »neuen Menschen«, mithin also das innere Neuwerden und eine veränderte Lebensführung des Menschen, befördern können? Die affirmative Bejahung dieser Frage in Theorie und Praxis der Architektur zu Beginn des 20. Jahrhunderts steht in deutlichem Kontrast zu Karl Barths schroffer Ablehnung jeglicher Anschaulichkeit in der Rede vom »neuen Menschen« in seiner Interpretation des Römerbriefs (21922). Der Artikel diskutiert architekturphilosophische Überlegungen Otto Bartnings (1883–1959) aus der Zeit nach den beiden Weltkriegen und stellt zwei seiner sogenannten »Notkirchen« vor. Wir argumentieren, dass gerade im Verzicht auf eine der Architektur externe Programmatik wie beispielsweise eine Erziehung des Menschen Bartnings Kirchen aus sich heraus wirken und der Bau die Begegnung mit dem Gotteswort gleichsam performativ ermöglicht. Dabei koinzidieren anthropologische und theologische Bestimmungen des Heiligen.
Performance analysis of nonlinear crosstalk of WDM systems using modulation schemes criteria
Authors: Mohammed Nidhal Abd , Mansoor Riyadh , Abd Haider J. , Fadhil Hilal A. 
Published: August 2024

Abstract
Nonlinearities in optical fibers are regarded as the most significant barriers that endanger the effectiveness of the optical transmission system and pose a threat to communication quality. Four-wave mixing (FWM) is one of the most important nonlinear effects that greatly reduces the wavelength-division multiplexing (WDM) system performance at high data rates over extended transmission distances. This research examines, and assesses, numerically, the behavior of a 4-channel, 40 Gbps WDM system under the effect of the FWM under various tuning parameters, including dispersion, input power, and wavelength spacing. The system model was built using OptiSystem software, and then three different modulation formats, namely, Non-return-to-zero-frequency shift keying, Return-to-zero frequency shift keying, and differential phase shift keying (DPSK) are used to assess the FWM power penalty. The results demonstrate that the FWM power penalty obtained with 1 nm wavelength separation in the DPSK method is dramatically reduced to −35 dBm. This study also demonstrates that when power variation is taken into consideration, the DPSK modulation scheme delivers a lower bit error rate in comparison to other modulation schemes.
On 𝜎-permutable subgroups of 𝜎-soluble finite groups
Authors: Wang Zhigang , Liu A-Ming , Safonov Vasily G. , Skiba Alexander N. 
Published: August 2024

Abstract
Let

σ
=

{

σ
i

∣

i
∈
I

}

\sigma=\{\sigma_{i}\mid i\in I\}

be some partition of the set of all primes and 𝐺 a finite group.
Then 𝐺 is said to be 𝜎-full if 𝐺 has a Hall

σ
i

\sigma_{i}

-subgroup for all

i
∈
I

i\in I

and 𝜎-primary if 𝐺 is a

σ
i

\sigma_{i}

-group for some 𝑖.
In addition, 𝐺 is 𝜎-soluble if every chief factor of 𝐺 is 𝜎-primary and 𝜎-nilpotent if 𝐺 is a direct product of 𝜎-primary groups.
We write

G

N
σ

G^{\mathfrak{N}_{\sigma}}

for the 𝜎-nilpotent residual of 𝐺, which is the intersection of all normal subgroups 𝑁 of 𝐺 with 𝜎-nilpotent

G
/
N

G/N

.
A subgroup 𝐴 of 𝐺 is said to be 𝜎-permutable in 𝐺 provided 𝐺 is 𝜎-full and 𝐴 permutes with all Hall

σ
i

\sigma_{i}

-subgroups 𝐻 of 𝐺 (that is,

A
⁢
H

=

H
⁢
A

AH=HA

) for all 𝑖.
And 𝐴 is 𝜎-subnormal in 𝐺 if there is a subgroup chain

A
=

A
0

≤

A
1

≤
⋯
≤

A
n

=
G

A=A_{0}\leq A_{1}\leq\cdots\leq A_{n}=G

such that either

A

i
−
1

⁢
⊴
⁢

A
i

A_{i-1}\trianglelefteq A_{i}

or

A
i

/

(

A

i
−
1

)

A
i

A_{i}/(A_{i-1})_{A_{i}}

is 𝜎-primary for all

i
=

1
,
…
,
n

i=1,\ldots,n

.
We prove that if 𝐺 is a 𝜎-soluble group, then 𝜎-permutability is a transitive relation in 𝐺 if and only if

G

N
σ

∩

A
G

=

G

N
σ

∩

A
G

G^{\mathfrak{N}_{\sigma}}\cap A^{G}=G^{\mathfrak{N}_{\sigma}}\cap A_{G}

for every 𝜎-subnormal subgroup 𝐴 of 𝐺.