bluuebunny/crossref_metadata_2025_split huggingface dataset:
The STELLAR trial: a phase II/III randomized trial of high-dose, intermittent sunitinib in patients with recurrent glioblastoma
Authors: Janssen Jorien B E , Brahm Cyrillo G , Driessen Chantal M L , Nuver Janine , Labots Mariette , Kouwenhoven Mathilde C M , Sanchez Aliaga Esther , Enting Roelien H , de Groot Jan Cees , Walenkamp Annemiek M E , van Linde Myra E , Verheul Henk M W 
Published: July 2024

Abstract
Previously, the tyrosine kinase inhibitor sunitinib failed to show clinical benefit in patients with recurrent glioblastoma. Low intratumoural sunitinib accumulation in glioblastoma patients was reported as a possible explanation for the lack of therapeutic benefit. We designed a randomized phase II/III trial to evaluate whether a high-dose intermittent sunitinib schedule, aimed to increase intratumoural drug concentrations, would result in improved clinical benefit compared to standard treatment with lomustine. Patients with recurrent glioblastoma were randomized 1:1 to high-dose intermittent sunitinib 300 mg once weekly (Q1W, part 1) or 700 mg once every two weeks (Q2W, part 2) or lomustine. The primary end-point was progression-free survival. Based on the pre-planned interim analysis, the trial was terminated for futility after including 26 and 29 patients in parts 1 and 2. Median progression-free survival of sunitinib 300 mg Q1W was 1.5 months (95% CI 1.4–1.7) compared to 1.5 months (95% CI 1.4–1.6) in the lomustine arm (P = 0.59). Median progression-free survival of sunitinib 700 mg Q2W was 1.4 months (95% CI 1.2–1.6) versus 1.6 months (95% CI 1.3–1.8) for lomustine (P = 0.70). Adverse events (≥grade 3) were observed in 25%, 21% and 31% of patients treated with sunitinib 300 mg Q1W, sunitinib 700 mg Q2W and lomustine, respectively (P = 0.92). To conclude, high-dose intermittent sunitinib treatment failed to improve the outcome of patients with recurrent glioblastoma when compared to standard lomustine therapy. Since lomustine remains a poor standard treatment strategy for glioblastoma, innovative treatment strategies are urgently needed.
Political Parties and Public Policies. A Review of the Spanish Evidence
Authors: Magre-Pont Jaume , Magontier Pierre , Solé-Ollé Albert 
Published: July 2024

Abstract
To what extent does the incumbent party’s identity shape public policies? We investigate this question by examining national and regional policies in Spain. First, we analyze the evolution of voter preferences, and ofthe platforms of the two mainstream parties (Partido Socialista Obrero Español [PSOE] and Partido Popular [PP]), and the newer challenger parties that emerged post-financial crisis (Ciudadanos, Podemos, and Vox). We focus on three key national-level issue dimensions: economic, social, and centralization. As expected, the right-wing PP adopts a more conservative stance on all dimensions compared to the left-wing PSOE. However, the policy gap between these two parties remains relatively stable until the mid-2000s, with party platforms tracking the evolution of citizen preferences. After this period, platforms start to diverge, especially in the case of new parties, which display radical stances on these dimensions. We also provide descriptive evidence suggesting that these platform differences have translated into enacted policies. Second, to offer causal evidence on the effect of party identity on policy decisions, we examine partisan disparities in regional fiscal policies. Our findings reveal significant differences in tax policy following the granting of tax autonomy to the regions, somewhat moderated by tax competition and fiscal limits.
Moving from Second Sight to Critical Consciousness Building: Using Social Justice Youth Development and Youth Participatory Action Research to Promote Praxis in Out-of-School Time
Authors: Bloomer Rebecka M , Brown Aishia 
Published: July 2024

Abstract
Youth development programs offer flexible environments for healing and positive identity development for youth facing discrimination and oppression. Programs often occur in out-of-school time (OST), a context that is clearly positioned in tandem with the education system to create complex relationships that lead to challenges in OST spaces. Youth development programs occurring in OST settings have the potential for resisting or replicating oppressive practices toward youth occurring in the education system. This article highlights a youth participatory action research (YPAR) project within an OST program using photovoice, field trips, and arts-based strategies. Eleven youth participated in the project over the course of nine months. Thematic content analysis of weekly photovoice and critical consciousness resulted in a primary theme of peeling back the layers. This theme encompassed the evolution of youth understanding the interconnectedness between their individual-level experiences of racism and broader community and systems-level inputs. This article describes critical consciousness development of OST youth participants through intentional engagement in critical dialogue, experiential field trips, and reflective art making.
Genomic analysis of foodborne Staphylococcus aureus obtained from unannounced food inspections between 2012 and 2021 in East China
Authors: Lu Chu , Xiao Wenjie , Yu Haoyun , Song Weiyi , Zhou Zhemin , Dong Ning , Fan Zhihai , Li Heng 
Published: July 2024

Abstract
Staphylococcus aureus is a significant cause of foodborne illness in China. Our investigation concentrated on the genetic characterization of foodborne S. aureus identified during unannounced inspections conducted in Suzhou from 2012 to 2021. Dominant clones included clonal complex (CC) 1, CC398, CC188, and CC7, with CC398 notably increasing in 2020–2021. The isolates commonly contained 1–3 plasmids, with rep5a (48.55%) and rep16 (44.51%) predominating. A concerning 24.3% showed multidrug resistance, particularly to penam (blaZ and mecA) and fosfomycin (fosB), with resistance rates rising from 32.7% to 53.3%, potentially linked to the increase in CC types like CC5, CC20, and CC25. Most isolates carried genes for virulence factors such as aureolysin, hemolysin, staphylokinase, and staphylococcal complement inhibitor. A significant increase in virulence genes, especially the enterotoxin gene sea, was observed, possibly associated with shifts in CC1 and CC7 prevalence. This underscores the necessity for ongoing surveillance to understand the genomic traits of S. aureus in ensuring food safety.
Dyadic Ambivalence in Couples Managing Early-Stage Alzheimer’s Disease: Linking Behavioral and Psychological Symptoms of Dementia to Life Satisfaction
Authors: Huo Meng , Gilligan Megan , Kim Kyungmin , Richards Nicole E , Fingerman Karen L , Zarit Steven H 
Published: July 2024

Abstract

Objectives
Caring for a spouse with Alzheimer’s disease (AD) can elicit considerable distress but there are also positive moments. A growing body of work has examined caregivers’ ambivalence in the care relationship and linked it to negative caregiver outcomes such as depression, but dyadic assessments of both parties’ perspectives are missing. We examined ambivalence in both people with AD and their spousal caregivers, seeking to identify the correlates and well-being outcomes of such ambivalence in this unique context.

Methods
Participants included 72 couples managing early-stage AD. People with AD and spousal caregivers independently self-reported positive and negative relationship qualities (used to indirectly calculate their ambivalence) and life satisfaction. Caregivers reported both partners’ demographic characteristics and their spouses’ behavioral and psychological symptoms of dementia (BPSD), focusing on memory-related behaviors and psychological symptoms.

Results
Path analyses revealed that the number and frequency of psychological symptoms in people with AD were positively associated with their own and caregivers’ ambivalence. Caregivers’ distress ratings of memory-related behaviors and psychological symptoms were positively associated with their ambivalence. Greater ambivalence was associated with lower life satisfaction in both spouses. BPSD directly affected both spouses’ life satisfaction but there were also indirect effects via ambivalence.

Discussion
This study utilizes a dyadic approach to assess ambivalence in dementia care. Findings reveal the conflicting emotions that couples experience as they cope with early-stage AD, identify sources of such ambivalence, and shed light on the development of dyadic interventions that can promote positive outcomes in both partners.
Estimating body composition using CT scans of cross-bred lambs fed at 2 feeding levels and 2 stages of maturity to inform predictive growth models
Authors: Keogh Thomas P , McGrath Shawn R , Allworth Maxwell B , Oddy Victor H 
Published: July 2024

Abstract
Livestock producers would benefit from more precise predictions of the growth response from nutrients consumed. Previously published models are often limited by the realities of data collection and are unable to account for alterations to body composition, due in part to the response of visceral organs to an alternate diet. The computerized tomography (CT) scanning of lambs enables the analysis of changes in body composition of individual animals over time, potentially supporting better model development and testing. The aim of this experiment was to develop a repeatable method for the analysis of live lamb body composition using CT scans. A secondary aim was to compare the data collected from CT scanning during a feeding trial to 2 predictive lamb growth models. Cross-bred lambs were fed 2 feeding levels at 2 stages of maturity, with CT scans at the beginning and end of each 8-wk feeding period. The CT scan-derived values for body composition taken at the beginning of feeding periods were used as inputs for 2 existing lamb growth models. Predictions of body composition were compared with CT scan-derived values at the end of feeding periods. The CT scan analysis method used a proportion of images from each lamb to reduce manual image editing. The method was developed by comparing the estimated mass and volume of empty body components using all available CT scans to estimated values using a reduced number of scans from 12 lambs. The CT scan-derived lean tissue mass aligned with model predictions at the end of each feeding period, however, CT scan-derived fat mass was greater than predictions by both models especially for the high feeding level at the later stage of maturity. These results highlight that the analysis of body composition using CT scans requires further validation, particularly for the viscera, and that models likely require refinement to better predict the efficiency of energy utilization by different tissues. The use of live animal CT scans can provide more accurate predictions of the growth of saleable products than measuring liveweight alone and will enable ruminant growth models to better adapt to different genetics and changing diets than comparative slaughter. To replicate the current data using comparative slaughter would require 4 times the animals, as individual lambs were CT scanned 4 times in this study, demonstrating the potential value of CT scanning in live animal research.
A mutation in POLR2A gene associated with body size traits in Dezhou donkeys revealed with GWAS
Authors: Yang Tao , Wang Min , Liu Yu , Li Yuanyuan , Feng Mo , Zhao Chunjiang 
Published: July 2024

Abstract
The Dezhou donkey is a famous local donkey breed in China. The aim of the present study was to identify the genes associated with the body size traits of the Dezhou donkey and facilitate the breeding activities of the donkeys. A total of 349 donkeys from 2 generations (113 individuals in F0 and 236 in F1) were analyzed with restriction-site-associated DNA sequencing. A genome-wide association study revealed that the region between 13.7 and 15.6 Mb of chromosome 13 is significantly associated with body sizes. Candidate genes related to body size development, including POLR2A, CHRNB1, FGF11, and ZBTB4, were identified. The results of GO and KEGG analysis indicated that the genes involved in many GO terms were related to metabolic processes and developmental processes. Additionally, a T&gt;C mutation (Chr13:14312485) was found at intron 10 of the POLR2A gene. The association analysis showed significant differences among genotypes for the size traits. The body size of the individuals with the TT genotype was significantly higher than that with the CC genotype. The results showed that the polymorphism of POLR2A has the potential to be used as a marker in the breeding programs of the Dezhou donkeys.
Benefit assessment of novel systemic therapies for bone and soft tissue sarcomas: a cross-sectional study
Authors: He Qiang , Wang Zhen , Mei Jie , Xie Chengxin , Sun Xin 
Published: July 2024

Abstract

Background
Bone and soft tissue sarcomas are rare malignancies, and their heterogeneity has limited the development of novel drugs. This study aimed to apply two validated tools to evaluate the clinical benefits of novel drug therapies for sarcoma developed over the last decade.

Methods
The PubMed and Embase databases were searched for randomized controlled trials (RCTs) of systemic therapies for sarcomas published between 2013 and 2023. Each trial was scored according to the European Society of Medical Oncology-Magnitude of Clinical Benefit Scale version 1.1 (ESMO-MCBS) and the American Society of Clinical Oncology-Value Framework version 2 (ASCO-VF).

Results
We included 52 RCTs in this study, of which 17 (32.7%) reported positive results that favored the experimental arm. The ESMO-MCBS grades were determined in 14/17 positive trials, and three of them (21.4%) met the threshold for meaningful clinical benefit. Likewise, ASCO-VF scores were calculated for 11/17 positive trials, and three of them (27.3%) met the threshold for meaningful clinical benefit. Weak correlation (r = 0.38, P = 0.277) and agreement (κ = 0.211, P = 0.490) were observed between the two frameworks.

Conclusion
Only a few RCTs with positive results have demonstrated substantial patient benefits for bone and soft tissue sarcomas over the past decade.
Turbulence, thermal pressure, and their dynamical effects on cosmic baryonic fluid
Authors: Wang Yun , He Ping 
Published: July 2024

ABSTRACT
We employ the IllustrisTNG simulation data to investigate the turbulent and thermal motions of the cosmic baryonic fluid. With continuous wavelet transform techniques, we define the pressure spectra, or density-weighted velocity power spectra, as well as the spectral ratios, for both turbulent and thermal motions. We find that the magnitude of the turbulent pressure spectrum grows slightly from $z=4$ to 2 and increases significantly from $z=2$ to 1 at large scales, suggesting progressive turbulence injection into the cosmic fluid, whereas from $z=1$ to 0, the spectrum remains nearly constant, indicating that turbulence may be balanced by energy transfer and dissipation. The magnitude of the turbulent pressure spectra also increases with environmental density, with the highest density regions showing a turbulent pressure up to six times that of thermal pressure. We also explore the dynamical effects of turbulence and thermal motions, discovering that while thermal pressure provides support against structure collapse, turbulent pressure almost counteracts this support, challenging the common belief that turbulent pressure supports gas against overcooling.
Hedge funds and the positive idiosyncratic volatility effect
Authors: G. Bali Turan , Weigert Florian 
Published: July 2024

Abstract
While it is established that idiosyncratic volatility is negatively priced in the cross-section of stock returns, the relation between idiosyncratic volatility and hedge fund returns is largely unexplored. We document that hedge funds with high idiosyncratic volatility earn higher future risk-adjusted returns of 6 percent p.a. than hedge funds with low idiosyncratic volatility. The outperformance arises because hedge funds trade high idiosyncratic volatility stocks wisely. They pick high volatility stocks when they are underpriced and short-sell high volatility stocks when they are overpriced. Our results support the notion that hedge funds’ idiosyncratic volatility is a measure of managerial skill.
Does Spinal Cord-Canal Mismatch Adversely Affect the Clinical Outcomes of Anterior Cervical Discectomy and Fusion for the Treatment of Cervical Myelopathy?
Authors: Park Sehan , Choi Ji Uk , Kim San , Hwang Chang Ju , Cho Jae Hwan , Lee Dong-Ho 
Published: July 2024

Study Design.
Retrospective cohort study.

Objective.
To clarify whether clinical outcomes of anterior cervical discectomy and fusion (ACDF), is affected by presence of spinal canal-cord mismatch (SCCM).

Summary of Background Data.
SCCM is considered a factor that would moderately influence surgeons to perform posterior surgery since it could widen the spinal canal, while an anterior approach could only remove degenerative pathologies grown into the spinal canal.

Materials and Methods.
We retrospectively reviewed 186 patients who underwent ACDF and had been followed-up for more than two years. Patients with spinal cord occupation ratio (SCOR) of ≥0.7 were classified into the SCCM group, while those with a SCOR of <0.7 were included in the no-SCCM group. Patient demographics, cervical sagittal parameters, neck pain visual analog scale (VAS), arm pain VAS, and Japanese Orthopedic Association (JOA) score were assessed. JOA score was the primary outcome of the study.

Results.
One hundred and forty-seven patients (79.0%) were included into the no-SCCM group, while 39 patients (21.0%) were classified into the SCCM group. Postoperative radiographic parameters including C2–C7 lordosis, C2–C7 sagittal vertical axis, and range of motion did not significantly differ between the two groups. Neck pain VAS, arm pain VAS, and JOA score (no-SCCM group, from 13.7±2.5 to 14.6±2.3, P<0.001; SCCM group, from 13.8±1.6 to 15.0±2.0, P<0.001) significantly improved after the operation in both groups, and results were not significantly different between the two groups. Furthermore, SCOR was not significantly associated with JOA recovery rate at two years postoperatively in linear regression analysis.

Conclusion.
Clinical and radiographic outcomes of ACDF were not affected by the presence of SCCM. Furthermore, SCOR was not significantly associated with neurological recovery at two years of follow-up. Therefore, ACDF can be safely and effectively applied for treating cervical myelopathy, regardless of the presence of SCCM, when other factors favor the anterior approach.

Level of evidence.
Level III.
Dynamically Normalized Pupillometry for Detecting Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage
Authors: Klug Julian , Martins Joana , De Trizio Ignazio , Carrera Emmanuel , Filipovic Miodrag , Hostettler Isabel Charlotte , Pietsch Urs 
Published: July 2024

OBJECTIVES:
Delayed cerebral ischemia (DCI) is a major driver of morbidity after aneurysmal subarachnoid hemorrhage (aSAH). Quantitative pupillometry has been shown to be of prognostic value after acute neurological injury. However, the evidence for the use of pupillometric features for the detection of DCI has been conflicting. The aim of this study was to investigate the prognostic value of frequent pupillometric monitoring for DCI detection.

DESIGN:
Observational cohort study from a prospective aSAH registry.

SETTING:
Tertiary referral center.

PATIENTS:
Adult patients with confirmed aSAH admitted to the ICU between March 2019 and December 2023.

INTERVENTIONS:
None.

MEASUREMENTS AND MAIN RESULTS:
One hundred fourteen patients were included, of which 31 (27.2%) suffered from DCI. All patients underwent frequent pupillometry (every 3 hr). We determined the absolute value of the neurological pupil index (NPi) and constriction velocity (CV), and their value normalized to the maximal recorded value between the admission and the pupillometry measure to account for personalized baselines. The association between pupillometry values and the occurrence of DCI within 6–24 hours was investigated. Normalized CV had the best discriminative performance to identify DCI within 8 hours, with an area under the receiver operating characteristic curve of 0.82 (95% CI, 0.69–0.91). NPi, as well as non-normalized metrics, were not significantly associated with DCI.

CONCLUSIONS:
Normalized CV has a clinically and statistically significant association with the occurrence of DCI after aSAH. Frequent quantitative pupillometry could improve the multimodal monitoring of patients after aSAH with the goal of improving the identification of patients likely to benefit from therapeutic interventions.
Estrogen deficiency in the menopause and the role of hormone therapy: integrating the findings of basic science research with clinical trials
Authors: Yang Jane L. , Hodara Emmanuelle , Sriprasert Intira , Shoupe Donna , Stanczyk Frank Z. 
Published: July 2024

Abstract
Menopause, defined by the cessation of menstrual cycles after 12 months of amenorrhea not due to other causes, is associated with significant hormonal changes, primarily a decrease in estrogen, androgen, and progesterone levels. This review delves into the effects of estrogen deficiency during the perimenopausal transition and postmenopause, integrating the findings of basic science with clinical trials. Here, we first outline the variation in endogenous estrogens before and after menopause, exploring both genomic and nongenomic actions of estrogen and its estrogen receptors throughout the body. Next, we detail the spectrum of menopausal symptoms, from acute vasomotor, urogenital, and psychological issues during perimenopause to chronic reproductive, cardiovascular, neurological, skeletal, dermatologic, immune, and digestive changes postmenopause. Finally, we evaluate the role of hormone therapy in alleviating these symptoms, weighing its benefits against known risks. Publicizing these findings and an accurate representation of the risks and benefits of estrogen replacement to our aging patients is fundamental to improving their care, quality, and even quantity of life.
Effects of herbal medicine on ovulation in premature ovarian insufficiency patients during in vitro fertilization
Authors: Kim Dong In 
Published: July 2024

Introduction:
Premature ovarian insufficiency (POI) is a condition in which menopause occurs before the age of 40 and is known to be a relatively common disease that occurs in 1% of all women. The only way for patients diagnosed with POI to become pregnant is through oocyte donation, in which fertilized ovums are transplanted by receiving oocytes from donors.4 Can POI patients increase their chances of normal ovulation? POI patients were more likely to observe and collect follicles larger than the average 15 mm diameter when herbal medicine was administered.

Methods:
This study is a retrospective cohort study conducted on POI patients undergoing in vitro fertilization (IVF) who visited our hospital from 2020 to 2022. We would like to report the response rate to gonadotropin-releasing hormone (GnRH) during IVF in the hyperovulation induction low response group after herbal medicine treatment. Statistical analysis was performed using IBM’s SPSS Statistics to verify significance with a P-value<0.05.

Results:
In recovering ovarian POI patient's ovarian function, herbal medicine treatment increased the response rate to GnRH (the number of oocytes collected) during IVF, follicle-stimulating hormone (FSH) and cortisol levels decreased, and estradiol (E2) and luteinizing hormone (LH) levels increased.

Conclusions:
It was confirmed that herbal medicine treatment can increase the probability of normal ovulation in patients with idiopathic POI with high cortisol levels. Until now, it has been known that ovarian function cannot be recovered once irreversibly decreased, but by increasing the probability of ovulation through herbal medicine treatment, it is significant that it may be possible to suppress ovarian aging or preserve fertility.