bluuebunny/crossref_metadata_2025_split huggingface dataset:
Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans
Authors: Esposito Teresa , Varriale Bruno , D’Angelo Rosalia , Amato Aldo , Sidoti Antonina 
Published: December 2014

Abstract
Flavin-containing mono-oxygenases (FMOs) are a family of microsomal chemical- and drug-metabolizing enzymes. FMO3 is a major FMO form in adult mouse and human liver. FMO3 mutations have been associated with the incidence and severity of trimethylaminuria (TMAU), a metabolic disorder characterized by the inability of the affected individual to metabolize the odorous trimethylamine to its non-odorous N-oxide. In addition to this primary genetic form, there are other forms of TMAU that support the hypothesis that FMO3 activity may be modulated by steroid hormones. To understand the molecular mechanism involved in the regulation of Fmo3 gene expression by steroid hormones, we performed this study in an in vitro cellular system, mouse liver cells, and on the human FMO3 gene. Dexamethasone, 5α-dihydrotestosterone, thyroid hormone, and progesterone had no effect on the accumulation of Fmo3 mRNA. The use of increased concentration of theophylline inhibited estrogen receptor α (ERα)-mediated transcription of Fmo3 mRNA. 17β-Estradiol inhibited Fmo3 mRNA accumulation. The use of ICI 164,384 abolished the inhibitory effect induced by estrogen. Gel-shift analyses showed a binding in the 5′ region of the Fmo3 gene. This binding was abrogated by an excess of a cDNA containing an estrogen-responsive element. An estrogen-binding site was also present in the first intron of the human gene, as demonstrated by the gel-shift assay. Supershift experiments confirmed the binding of ERα in both mouse and human samples. Furthermore, chromatin immunoprecipitation assay confirmed the binding of ERα in the promoter region of mouse Fmo3 and in the first intron of the human FMO3 gene. Thus, 17β-estradiol plays a fundamental role in the regulation of Fmo3 gene transcription.
Visual and sensorimotor cortices mapping during awake resection of lesion on the right periatrium: a case report on brainwaves and their peculiar patterns
Authors: Idris Zamzuri , How Ch’ng Chee , Abdullah Jafri Malin 
Published: December 2014

Abstract

Background: Advances in neurosurgery have allowed for more sophisticated mapping of various eloquent neural structures including the visual cortex. Applications of various modalities of new technologies allow accurate brain mapping for neurosurgical planning and preservation of functions in patients with lesions involving the eloquent cortex. The authors demonstrate the use of various new technologies for accurate presurgical planning, preservation of brain functions, and depiction of patterns of cortical brainwaves, which relate to motor networks and continuous visual stimuli.

Methods: A patient with a right periatrial lesion involving the optic radiation with no visual field deficits was operated under an awake state and under continuous contralateral electrocorticography and visual monitoring. Presurgically, extra-operative brain mapping for visual-, sensory-, and motor-evoked magnetic fields were completed using magnetoencephalography (MEG). The dipole areas were identified, and the images were fused with a 116-region cortical brain atlas. The ideal trajectory was planned based on these images and diffusion tensor imaging (tractography). The trans-sulcal approach via the inferior parietal lobule was elected. Prior to resection, intra-operative stimulation and mappings were done and continuous visual-evoked potentials were monitored during the actual resection.

Results: A good agreement for eloquent areas was identified based on extra-operative MEG and intra-operative neurostimulation mappings. The patient had no new neurological or visual-field deficits after the surgery. Certain patterns of brainwaves for motor cortex and visual stimulation were obtained: (a) spikes at the contralateral sensorimotor area when the motor strip was stimulated and (b) up-down and dense-loose continuous visual-evoked brainwaves at the occipital pole toward flashing checkerboard visual stimulation.

Conclusions: A combination of extra- and intra-operative brain mappings should ideally be done in patients harboring lesions near eloquent areas. The continuous visual-evoked potential monitoring, using a grid electrode and flashing checkerboard and contralateral sensorimotor responses, observed in our case is interesting and needs further studies.
Endoscopic anatomy of the intracisternal oculomotor nerve: a new segmentation based on the topography of the arachnoid membranes
Authors: Kurucz Peter , Baksa Gábor , Patonay Lajos , Thaher Firas , Hopf Nikolai J. 
Published: December 2014

Abstract

Objective: The aim of our study was to investigate the detailed endoscopic anatomy of the intracisternal portion of the oculomotor nerve and to update the present knowledge of its related anatomy with the newest research on the topography of the arachnoid membrane system of the skull base.

Methods: This study was performed on 50 fresh human cadaveric specimens post-mortem not more than 72 h. In each specimen, the intracranial arterial system was injected with red gelatin solution. We used the endoscope-controlled and endoscope-assisted microsurgical techniques applied through the minimally invasive supraorbital keyhole craniotomy to perform our dissections.

Results: We divided the intracisternal oculomotor nerve into three segments in this study. These are the interpeduncular segment, located in the interpeduncular fossa and surrounded by dens arachnoid trabeculae around the thalamoperforating arteries; the tentorial segment, located between the posterior cerebral and superior cerebellar arteries and the posterior petroclinoid fold and surrounded by the elements of the clival and tentorial arachnoid membrane groups; and the trigonal segment located on the surface of the oculomotor trigone between the posterior petroclinoid fold and the dural exit of the nerve into the cavernous sinus and surrounded by the posteriorly located membranes of the carotid membrane group.

Conclusions: Our findings support the more accurate understanding of the physiology of the arachnoid membrane system and the pathophysiology of space-occupying lesions in the region of the oculomotor nerve. Therefore, our results may support performing more atraumatic surgery in this area.
Silver nanoparticles influenced rat serum metabolites and tissue morphology
Authors: Adeyemi Oluyomi Stephen , Adewumi Ifeoluwa , Faniyan Temiloluwa O. 
Published: December 2014

Abstract

Background: Silver nanoparticles (AgNPs) are increasingly and extensively being applied for biomedical purposes. However, studies on the safety/toxicity profiles of AgNPs are limited. This necessitates the further studies in this direction. Here, we studied the effect of AgNP administration on rat serum metabolites and tissue morphology.

Methods: Rats were randomly distributed into eight groups of five animals each. Oral administration of AgNPs to rats at 100, 1000, and 5000 mg/kg was done daily and carried out for 7, 14, and 21 days alternately. The control received distilled water. Animals were sacrificed under diethyl ether anesthesia 24 h after cessation of last treatments. The blood and vital organs were harvested and prepared for biochemical and histopathology examinations, respectively.

Results: Data revealed that AgNP administration at the different dosages caused elevated serum urea and creatinine levels. On the other hand, levels of inorganic phosphate in rat serum following administration of AgNPs were significantly (p<0.05) reduced. Also, administration at 1000 and 5000 mg/kg AgNPs in rats decreased serum levels of sodium. In contrast, AgNP administration in rats caused elevated (p<0.05) serum potassium levels. The histopathological presentations show diverse inimical alterations to cellular architecture in rats administered with AgNPs.

Conclusions: We show evidence suggesting that AgNPs may have potential to adversely affect the kidney functions as well as capability to cause myriad of cellular damage.
Reclaiming Commons Rights: Resources, Public Ownership and the Rights of Future Generations
Authors: Mishori Daniel 
Published: December 2014

Abstract
The claim that the public “owns” natural resources or public spaces is an event that has recurred in the past decade in Israeli social and environmental struggles and campaigns. Analyzing two high-profile issues – the Palmachim beach and the controversies over the offshore natural gas revenues and export – this paper argues that the rhetoric of public ownership reveals an emerging “commons sense,” a public consciousness of collective ownership of natural resources and public space, interwoven with a sense of responsibility for their long-term preservation and for future generations. The paper shows that the rhetoric of public ownership is best accounted for by The Commons discourse, which conceptualizes resistance to enclosure (privatization), reclaiming public rights and affinity with future generations. The paper surveys various conceptions of the commons discourse and its possible integration with human rights. So far, discussion of the Commons with relation to human rights emphasized the rights to subsistence and to a healthy environment, i.e. derivatives of the basic human rights for life and health, the standard list of environmental rights. However, in order to conform to the sentiments of Israeli “commoners,” commons rights should also affirm public ownership rights over natural and shared resources which, when understood as inherently diachronic and trans-generational, implicate also sustainability and long-term social and intergenerational justice. These rights may conflict with the Lockean conception of private property as curved off the commons. Therefore, conceptualizing such rights necessitates rethinking the idea of private property versus public and future-generations’ collective good.
Registries
Authors: Arruñada Benito 
Published: December 2014

Abstract
Governments and international development agencies often fail in their efforts to build and reform property and company registries. They implement misguided policies rooted in a poor understanding of the role that registries play in the modern economy. This work aims to remedy this situation by first presenting a theory of registries as market-enabling institutions which, by making private contracts verifiable by judges, enable truly impersonal (i.e., asset-based, in rem) trade without endangering property enforcement. The theory is then applied to discuss and guide major policy decisions that reformers face in the areas of land titling and business formalization, emphasizing the principle of registry independence, identifying courts as the key users of registries, clarifying the main choices of titling and formalization projects, and pointing out the presence of diseconomies of scope between contractual and administrative registries.
Instrumental characterization of geological materials and their synthetic analogs
Authors: Murad Enver 
Published: December 2014

Abstract
The mineralogy of geological samples is generally determined by optical microscopy or X-ray diffraction. 57Fe Mössbauer and Raman spectroscopies are effective alternative non-destructive nuclear and vibrational instrumental techniques that can – in conjunction with the former procedures, and all the more when these fail – serve for mineral characterization. In favorable cases these spectroscopic techniques enable, beyond a mere general characterization, the conclusive identification of selected minerals.
Effect of liquid butadiene rubber on mechanical properties of polyamide 11/polyamide 12 blends
Authors: Simek Jan , Dockalova Veronika , Hrdlicka Zdenek , Duchacek Vratislav 
Published: December 2014

Abstract
Polyamide 11 (PA 11)/polyamide 12 (PA 12) blends with and without liquid polybutadiene (LB) containing isocyanate end groups (LBD) were prepared in the Brabender plastograph. The rubber was added in order to increase the impact strength of the polyamides. Tensile strength and elongation at the upper yield point and hardness were also measured. Thermal properties were determined by differential scanning calorimetry (DSC) and dynamic mechanical analysis (DMA). Fourier transform infrared (FTIR) spectroscopy was used to determine functional groups of polyamides and to reveal possible reactions between the polyamides and LBD. Intrinsic viscosity, measured by an Ubbelohde viscometer, was used to calculate molar mass. The LB has been found as a useful modifier of impact strength.
Remarks on the chronology of the Lengyel culture in the western half of the Carpathian Basin based on the analysis of funerary assemblages
Authors: Diaconescu Dragoş 
Published: December 2014

Methoden derLes nouvelles méthodes de datation et d’analyse des correspondances et AMS nous permettent de préciser et d’améliorer les schémas de chronologie relative dont nous disposons. Ainsi, pour la culture de Lengyel, (également connue sous le nom de Groupe morave-autrichien oriental), des schémas de chronologie absolue sont disponibles, mais la situation du Bassin des Carpates est actuellement différente: il n’existe pratiquement aucune date publiée pour la culture de Lengyel dans cette région. Un nouveau modèle chronologique pour la culture de Lengyel est proposé ici, sur la base d’une étude de la céramique retrouvée dans les ensembles funéraires qui fait usage de la méthode de l’analyse des correspondances et des approches Bayésiennes. Il en résulte que certains synchronismes (tels Lengyel I and II = Néolithique final = cultures de Tisza-Herpály: Lengyel III = Chalcolithique ancien = culture de Tiszapolgár) ne semblent plus valables.The AMS data and correspondence analysis methodology could correct and improve the relative chronology picture. For Lengyel culture (also named Moravian-Eastern-Austrian group) absolute chronological models have already been proposed. In Carpathian Basin the situation is quite different for the moment. Almost no absolute data are published for Lengyel culture in this area. A new chronological model for Lengyel culture is proposed based on the morphological aspects of the pottery inventory from funerary contexts and using correspondence analysis cross-checked by Bayesian approaches. The most interesting fact is that relative chronology synchronisms such as Lengyel I and II = Late Neolithic = Tisza-Herpály cultures and Lengyel III = Early Copper Age = Tiszapolgár culture do not seem to be valid anymoreModelarea datelor AMS şi utilizarea analizei de corespondenţă, ca şi metode de lucru, pot îmbunătăţi şi corecta tabloul cronologiei relative. Pentru cultura Lengyel (numită şi Grupul Morav – est-austriac) au fost deja propuse modele cronologice absolute. În Bazinul Carpatic situaţia este la acest moment un pic diferită. Extrem de puţine date radiocarbon pentru cultura Lengyel sunt publicate pentru acest areal. Un nou model cronologic al culturii Lengyel este propus aici, bazat pe analiza aspectelor morfologice ale inventarului ceramic provenit din contexte funerare. Analiza de corespondenţă, dublată de abordări Bayesiene ale datelor 14C, au fost folosite ca şi metode de lucru. Cel mai interesant aspect al rezultatelor obţinute este faptul că sincronisme ale cronologiei relative de tip Lengyel I–II = Neolitic Târziu = culturile Tisza-Herpály şi Lengyel III = Epoca Timpurie a Cuprului = cultura Tiszapolgár par a nu mai fi valabile.
Influence of bis(triethoxysilylpropyl) tetrasulfide amount on the properties of silica-filled epoxidized natural rubber-based composites
Authors: Al-Hartomy Omar A. , Al-Ghamdi Ahmed A. , Al Said Said A. Farha , Dishovsky Nikolay , Mihaylov Mihail 
Published: December 2014

AbstractThe aim of the present article is to investigate the influence of the amount of bis(triethoxysilylpropyl) tetrasulfide on the curing characteristics and mechanical and dynamic properties of rubber composites based on epoxidized natural rubber (Epoxyprene 50) filled with 70 phr silica. The obtained results showed that although the interaction between the epoxy groups of epoxidized natural rubber and the silanol groups of silica through hydrogen bonds improves the dispersion of filler in the rubber matrix, the presence of silane coupling agents is necessary to obtain rubber compounds and vulcanizates with good vulcanization characteristics and mechanical and dynamic properties.
1200 Jahre von Abrahams Geburt bis zum Tempelbau
Authors: Koenen Klaus 
Published: December 2014

According to the salvation-historical concept of the Hebrew Bible (MT), Solomon started building the temple exactly 1200 years after Abraham was born. The 480 (= 12 × 40) years between the exodus and the building of the temple are preceded by 430 years in Egypt, which correspond to the 430 years between the building of the temple and its destruction, according to biblical chronology. The 430 years in Egypt are preceded by the 215 years (half of 430) of the ancestors’ stay in Canaan. In order to ensure that events align with the time period of 1200 years, Abraham’s move to Canaan is dated in his 75Selon la conception de l’histoire du salut de la Bible hébraïque (TM), Salomon aurait débuté la construction du Temple exactement 1200 ans après la naissance d’Abraham. La période de 480 (= 12 × 40) ans entre l’Exode et la construction du Temple est précédée par les 430 ans du séjour en Egypte, qui correspondent aux 430 ans qui séparent la construction du Temple de sa destruction, selon la chronologie biblique. Les 430 ans en Egypte sont précédés par 215 ans (moitié de 430) de séjour des Patriarches en Canaan. Afin d’obtenir le chiffre global de 1200 ans, la migration d’Abraham en Canaan a été datée de sa 75ème année. Ces dates veulent indiquer que c’est Dieu qui dirige l’histoire; elles ne sont en conséquence pas exploitables historiquement.Nach der heilsgeschichtlichen Konzeption der Hebräischen Bibel (MT) begann Salomo mit dem Tempelbau genau 1200 Jahre nach Abrahams Geburt. Den 480 (= 12 × 40) Jahren zwischen Exodus und Tempelbau gehen 430 Jahre Ägyptenaufenthalt voran, die den 430 Jahren entsprechen, die dem Tempelbau nach biblischer Chronologie bis zur Tempelzerstörung folgen. Den 430 Jahren in Ägypten gehen 215 Jahre (Hälfte von 430) der Väter in Kanaan voran. Um auf insgesamt 1200 Jahre zu kommen, wurde Abrahams Umzug nach Kanaan in sein 75. Lebensjahr datiert. Die Daten wollen zeigen, dass Gott die Geschichte lenkt; sie sind folglich historisch nicht auswertbar.
The Body and Its Boundaries: The Coherence of Conceptual Metaphors for Job’s Distress and Lack of Control
Authors: de Joode Johan 
Published: December 2014

There is a cluster of metaphors that is constitutive of Job’s description of his situation, but that has not been researched systematically, viz. boundary metaphors. The present contribution uses cognitive linguistic insights to uncover and explain several metaphors that use the conceptsIl est une série de métaphores constitutives de la description par Job de sa situation qui n’ont pas encore été étudiées de manière systématique, à savoir les métaphores-limites. Cette étude utilise les acquis de la linguistique cognitive afin de dévoiler et d’élucider diverses métaphores dans le livre de Job, celles qui utilisent les concepts d’Es gibt eine Reihe von Metaphern, die für Hiobs Beschreibung seiner Situation konstitutiv, aber noch nicht systematisch erforscht worden sind, nämlich Begrenzungs-Metaphern. Der vorliegende Beitrag benutzt Einsichten der kognitiven Linguistik, um im Buch Hiob verschiedene Metaphern aufzudecken und zu erklären, die die Konzepte
Historical Candidates for the Fallen King in Sirach 10,10
Authors: Gregory Bradley C. 
Published: December 2014

Sirach 10,9–11 describes an arrogant king who comes to his death very suddenly. While previous scholarship has focused on Ptolemy IV and Antiochus III as the probable historical referents, it is argued here that the mysterious death of Alexander the Great is more likely to be the model.Sir. 10,9–11 décrit un roi arrogant qui voit sa mort survenir soudainement. Alors que la recherche antérieure y voyait les figures de Ptolémée IV et Antiochus III comme modèles historiques probables, la présente étude soutient que le modèle en est fourni par la mort mystérieuse d’Alexandre le Grand.Sir 10,9–11 beschreibt einen arroganten König, der sehr plötzlich zu Tode kommt. Während frühere Forschung sich auf Ptolemäus IV. und Antiochus III. als wahrscheinliche historische Vorbilder konzentriert hat, wird in diesem Beitrag die These vertreten, dass der mysteriöse Tod Alexanders d. Gr. das wahrscheinlichere Vorbild darstellt.
Natural genetic variation impacts expression levels of coding, non‐coding, and antisense transcripts in fission yeast
Authors: Clément‐Ziza Mathieu , Marsellach Francesc X , Codlin Sandra , Papadakis Manos A , Reinhardt Susanne , Rodríguez‐López María , Martin Stuart , Marguerat Samuel , Schmidt Alexander , Lee Eunhye , Workman Christopher T , Bähler Jürg , Beyer Andreas 
Published: November 2014

AbstractOur current understanding of how natural genetic variation affects gene expression beyond well‐annotated coding genes is still limited. The use of deep sequencing technologies for the study of expression quantitative trait loci (eQTLs) has the potential to close this gap. Here, we generated the first recombinant strain library for fission yeast and conducted an RNA‐seq‐based QTL study of the coding, non‐coding, and antisense transcriptomes. We show that the frequency of distal effects (trans‐eQTLs) greatly exceeds the number of local effects (cis‐eQTLs) and that non‐coding RNAs are as likely to be affected by eQTLs as protein‐coding RNAs. We identified a genetic variation of swc5 that modifies the levels of 871 RNAs, with effects on both sense and antisense transcription, and show that this effect most likely goes through a compromised deposition of the histone variant H2A.Z. The strains, methods, and datasets generated here provide a rich resource for future studies.
Early Weight Loss Nomograms for Exclusively Breastfed Newborns
Authors: Flaherman Valerie J. , Schaefer Eric W. , Kuzniewicz Michael W. , Li Sherian X. , Walsh Eileen M. , Paul Ian M. 
Published: December 2014

BACKGROUND:
The majority of newborns are exclusively breastfed during the birth hospitalization, and weight loss is nearly universal for these neonates. The amount of weight lost varies substantially among newborns with higher amounts of weight loss increasing risk for morbidity. No hour-by-hour newborn weight loss nomogram exists to assist in early identification of those on a trajectory for adverse outcomes.

METHODS:
For 161 471 term, singleton neonates born at ≥36 weeks’ gestation at Northern California Kaiser Permanente hospitals in 2009–2013, data were extracted from the birth hospitalization regarding delivery mode, race/ethnicity, feeding type, and weights from electronic records. Quantile regression was used to create nomograms stratified by delivery mode that estimated percentiles of weight loss as a function of time among exclusively breastfed neonates. Weights measured subsequent to any nonbreastmilk feeding were excluded.

RESULTS:
Among this sample, 108 907 newborns had weights recorded while exclusively breastfeeding with 83 433 delivered vaginally and 25 474 delivered by cesarean. Differential weight loss by delivery mode was evident 6 hours after delivery and persisted over time. Almost 5% of vaginally delivered newborns and &gt;10% of those delivered by cesarean had lost ≥10% of their birth weight 48 hours after delivery. By 72 hours, &gt;25% of newborns delivered by cesarean had lost ≥10% of their birth weight.

CONCLUSIONS:
These newborn weight loss nomograms demonstrate percentiles for weight loss by delivery mode for those who are exclusively breastfed. The nomograms can be used for early identification of neonates on a trajectory for greater weight loss and related morbidities.