bluuebunny/crossref_metadata_2025_split huggingface dataset:
Synthesis of [Zn(ΙΙ)BHPPDAH] as New Heterogeneous Catalyst without Being Immobilized on Any Support and Applied for Mannich Reaction
Authors: Khalifeh Reza , Sharghi Hashem , Rashidi Zahra 
Published: July 2013

ABSTRACTIn this paper, a novel heterogeneous complex of zinc with N,N‐bis(2‐hydroxyphenyl)pyridine‐2,6‐dicarboxamide(BHPPDAH) was synthesized. The catalyst was found to be a highly effective catalyst for the three‐component coupling reactions of aldehydes, alkynes, and amines (A3 coupling) via C–H activation. The reactions could be applied to both aromatic and aliphatic aldehydes and alkynes. Nearly quantitative yields of the desired products were obtained in most cases. The reaction proceeds without any cocatalyst or activator, and water is the only byproduct. The catalyst was quantitatively recovered from the reaction by a simple filtration and reused for five cycles with almost consistent activity.
Comprehensive assessment of prognostic markers for sinonasal squamous cell carcinoma
Authors: Takahashi Yoko , Bell Diana , Agarwal Garima , Roberts Dianna , Xie Tong‐Xin , El‐Naggar Adel , Myers Jeffrey N. , Hanna Ehab Y. 
Published: July 2013

ABSTRACTBackgroundLittle is known about the molecular signature of the rare tumor sinonasal squamous cell carcinoma (SNSCC). The purpose of this study was to comprehensively assess various molecular biomarkers in SNSCC.MethodsWe chose 13 markers for this study, which have been known as prognostic markers in head and neck squamous cell carcinoma. Expression of these markers was examined by either in situ hybridization or immunohistochemical methods on tissue microarrays made from 70 SNSCC specimens and 28 matched‐pair normal tissues from patients who underwent surgical resection at our institution. Expression data were correlated with patient clinicopathologic parameters and survival.ResultsOf the 13 markers, only epidermal growth factor receptor (EGFR) protein expression was associated with significantly shorter disease‐free survival (DFS; p = .01307). EGFR expression was also associated with shorter overall survival (OS), but the difference was not statistically significant.ConclusionTargeted inhibition of tumor EGFR expression may be a new approach to treating SNSCC. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1094–1102, 2014
Comparison of oncologic and functional outcomes after transoral robotic lateral oropharyngectomy versus conventional surgery for T1 to T3 tonsillar cancer
Authors: Lee Sei Young , Park Young Min , Byeon Hyung Kwon , Choi Eun Chang , Kim Se‐Heon 
Published: July 2013

ABSTRACTBackgroundWe performed transoral robotic surgery (TORS) or conventional surgery via a transoral or mandibulotomy approach in patients with tonsillar cancer and prospectively analyzed the oncologic outcomes and functional recovery of the 3 groups.MethodsBetween May 2008 and October 2011, 57 patients were enrolled in this prospective study.ResultsAlthough there was no significant difference in the survival rate of the TORS group (100%) and the conventional surgery group (96.7%), a higher rate of margin negativity was observed in the TORS group, especially in cases in which the tumor extends inferiorly. Patients who received TORS or conventional transoral procedures showed more rapid recovery of swallowing, shorter hospitalization, and shorter operation time than the mandibulotomy group.ConclusionDespite the weakness of this nonrandomized trial and the differences in T classification, TORS seemed to have distinct advantages over conventional transoral surgery and other conventional open surgery, but further studies are needed. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1138–1145, 2014
APPLYING BETA‐TYPE SIZE DISTRIBUTIONS TO HEALTHCARE COST REGRESSIONS
Authors: Jones Andrew M. , Lomas James , Rice Nigel 
Published: July 2013

SUMMARYThis paper extends the literature on modelling healthcare cost data by applying the generalised beta of the second kind (GB2) distribution to English hospital inpatient cost data. A quasi‐experimental design, estimating models on a sub‐population of the data and evaluating performance on another sub‐population, is used to compare this distribution with its nested and limiting cases. While for these data the beta of the second kind (B2) distribution and generalised gamma (GG) distribution outperform the GB2, our results illustrate that the GB2 can be used as a device for choosing among competing parametric distributions for healthcare cost data. Copyright © 2013 John Wiley & Sons, Ltd.
Comparative proteomics of glioma stem cells and differentiated tumor cells identifies S100A9 as a potential therapeutic target
Authors: Chen Song , Zhao Hongxin , Deng Jinmu , Liao Peng , Xu Zhongye , Cheng Yuan 
Published: July 2013

ABSTRACTRecent studies have suggested the existence of a small subset of cancer cells called cancer stem cells (CSCs), which possess the ability to initiate malignancies, promote tumor formation, drive metastasis, and evade conventional chemotherapies. Elucidation of the specific signaling pathway and mechanism underlying the action of CSCs might improve the efficacy of cancer treatments. In this study, we analyzed differentially expressed proteins between glioma stem cells and differentiated tumor cells isolated from the human glioma cell line, U251, via iTRAQ‐tagging combined with two dimensional liquid chromatography tandem MS analysis to identify proteins correlated with specific features of CSCs. Out of a total data set of 559 identified proteins, 29 proteins were up‐regulated in the glioma stem cells when compared with the differentiated cells. Interestingly, The expression level of S100A9 was fivefold higher in glioma stem cells than differentiated cells. Similar results were also observed in glioma stem cells derived from other glioma cells. More importantly, knockdown of S100A9 by RNA interference suppressed the proliferation of glioma stem cell line and decreased the growth of xenograft tumors in vivo. Taken together, these results indicate that the tumorigenesis potential of CSCs arises from highly expressed S100A9. J. Cell. Biochem. 114: 2795–2808, 2013. © 2013 Wiley Periodicals, Inc.
Macroanatomic, light and scanning electron microscopic studies of the pecten oculi in the stork (Ciconia ciconia)
Authors: Onuk Burcu , Tutuncu Serife , Alan Aydin , Kabak Murat , Ince Nazan Gezer 
Published: July 2013

ABSTRACTThis study was undertaken to investigate the pecten oculi of stork by using macroscopic, light and electron microscopic techniques. A total of 20 eyes that were obtained from 10 storks were used. The eyes were cleaned and isolated by dissection. After various procedures, four of the pecten oculi were examined by light microscope while the other four with an electron microscope. The remaining 12 eyes were assigned for macroscopic investigation. Pecten oculi of the stork were determined as accordion‐like structures that originated from n. opticus, consisting of 15–17 plica and projecting up to 2/5 of the diameter of the bulbus oculi. Light microscopic examination revealed two types of blood vessels. Afferent–efferent vessels were larger in diamater (40–45 µm), fewer in numbers, and the capillary vessels were smaller in diamater (2–5 µm) and more in numbers. There were granules including amount of melanin pigment at the apical part of the pleats. These granules were fewer and scattered randomly on the basal part of the pleats. As a result, pecten oculi in the stork, which is a migrating bird, were determined to be similar to those of other diurnal birds. Microsc. Res. Tech. 76:963–967, 2013. © 2013 Wiley Periodicals, Inc.
Magnetic field topology of the plasma sheet boundary layer
Authors: Teh W.‐L. , Nakamura R. , Baumjohann W. 
Published: July 2013

AbstractThe magnetic field topology of the plasma sheet boundary layer (PSBL) and its neighborhood is examined using a steady, two‐dimensional (2‐D), ideal MHD reconstruction method. We study four PSBL crossings, from the lobe toward the plasma sheet and back into the lobe, by the Cluster spacecraft in the Earth's magnetotail around (x, y, z) = (–17.3, 4.3, –6.3) RE in GSM. The four PSBL events are selected for having no intense ion beams. Two reconstructed magnetic field topologies give, for the first time, a 3‐D view of the PSBL, showing that one has a rather large gradient in the magnetic structure than another. A quantitative agreement of the current density between the reconstruction and curlometer methods is achieved for the overall results but with some discrepancies remaining, which will be discussed in terms of 3‐D and temporal effects. This agreement indicates that the current density can be estimated by the reconstruction if certain conditions are satisfied. Finally, we point out that a PSBL structure with intense ion beams would somehow degrade the accuracy of the ideal MHD reconstruction. This degradation may be due to the nonideal MHD properties and/or the transient properties of the ion beams. Further sophisticated investigations on this issue are needed for clarification.
Prognostic significance of HIF‐1a, CA‐IX, and OPN in T1–T2 laryngeal carcinoma treated with radiotherapy
Authors: Wachters Jan E. , Schrijvers Michiel L. , Slagter‐Menkema Lorian , Mastik Mirjam , de Bock Geertruida H. , Langendijk Johannes A. , Kluin Philip M. , Schuuring Ed , van der Laan Bernard F. A. M. , van der Wal Jacqueline E. 
Published: July 2013

Objectives/HypothesisTo examine the prognostic value of hypoxia inducible factor HIF‐1a, CA‐IX, and OPN on clinical outcome in patients with T1–T2 supraglottic laryngeal squamous cell carcinoma (LSCC) treated with primarily radiotherapy (RT).Study DesignRetrospective cohort study.MethodsTumor tissue sections of 60 patients with T1–T2 supraglottic LSCC treated with primarily radiotherapy were assessed immunohistochemically for expression of HIF‐1a, CA‐IX, and OPN. The relationship of protein expression and classical clinical parameters with clinical outcome was studied, using Cox regression and Kaplan‐Meier survival analyses.ResultsNeither HIF‐1a nor CA‐IX was of prognostic significance toward local control or overall survival in T1–T2 supraglottic LSCC. Cox regression survival analysis showed no relation between HIF‐1a or CA‐IX expression and local control (HR [hazard ratio] 1.07, CI [95% confidence interval] 0.29–3.87; HR 0.34, CI 0.04–2.58). Furthermore, OPN expression was not associated with local control (HR 1.37, CI 0.45–4.17) and overall survival (HR 0.99, CI 0.44–2.21). Our earlier findings in T1–T2 glottic LSCC (Schrijvers et al., 2008) could not be confirmed.ConclusionThe absence of prognostic significance for HIF‐1a and CA‐IX toward local control in supraglottic LSCC, unlike glottic LSCC, suggests that supraglottic LSCC might represent another biological entity.Level of EvidenceN/A. Laryngoscope, 123:2154–2160, 2013
Olfactory functions after transsphenoidal pituitary surgery: Endoscopic versus microscopic approach
Authors: Kahilogullari Gokmen , Beton Suha , Al‐Beyati Eyyub S. M. , Kantarcioglu Ozlem , Bozkurt Melih , Kantarcioglu Emrah , Comert Ayhan , Unlu M. Agahan , Meco Cem 
Published: July 2013

Objectives/HypothesisOlfactory disturbances could be observed following transsphenoidal pituitary surgeries. To our knowledge, no previous comparative studies on olfactory functions after transsphenoidal endoscopic and microscopic approaches have been performed.Study DesignProspective study comparing olfactory functions between endoscopic and microscopic transsphenoidal pituitary surgery.MethodTwenty‐five patients operated on with the endoscopic approach and 25 patients operated on with the microscopic transsphenoidal approach have been evaluated. The Smell Diskettes Olfaction Test was used during the preoperative period, 1 month after the operation, and 6 months after the operation. In addition, the relationship between intraoperative cerebrospinal fluid leakage from the pituitary and postoperative synechiae formation with olfaction system was evaluated. The results were analyzed using the Friedman test, Mann‐Whitney test, and Chi‐Square test.ResultsIn the endoscopic group, there were two hyposmic patients and no anosmic patients. In the microscopic group, there were 13 hyposmic patients and five anosmic patients. The data was statistically different between both groups (P <0.05). Cerebrospinal fluid leakage was observed in nine patients in the endoscopic group and in 10 patients in the microscopic group. There was no statistically significant difference between cerebrospinal fluid leakage and olfactory disturbances in both groups (P >0.05). Synechia was observed in nine patients in the microscopic group and in only one patient in the endoscopic group. There was a statistically significant difference between the presence of synechia and olfactory disturbances (P <0.05).ConclusionsThis is the first study to seek the difference between the endoscopic and microscopic transsphenoidal approaches on the olfactory system during pituitary surgery. The obtained results indicate that an endoscopic approach seems to be more advantageous than a microscopic approach for protecting olfactory system and function.Level of Evidence4. Laryngoscope, 123:2112–2119, 2013
Lateral pharyngotomy for selected invasive squamous cell carcinoma of the lateral oropharynx—part I: How
Authors: Laccourreye Ollivier , Benito José , Menard Madeleine , Garcia Dominique , Malinvaud David , Holsinger Christopher 
Published: July 2013

Objectives/HypothesisTo revisit the surgical technique of lateral pharyngotomy in patients with selected, isolated, and untreated invasive squamous cell carcinoma of the lateral oropharynx. To describe postoperative management, complications, and functional outcomes.Study DesignRetrospective review from a French university teaching hospital.MethodsNinety‐one patients consecutively underwent lateral pharyngotomy for selected T1–T4 squamous cell carcinoma of the lateral oropharynx.ResultsOf the patients, 73.6% and 98.9% experienced an uncomplicated surgical and medical postoperative course, respectively. There were no intraoperative deaths, but a single patient died in the immediate postoperative period from carotid rupture following salivary oropharyngeal fistula. The most common significant complications were severe postoperative swallowing impairment, pneumonia from aspiration, and salivary oropharyngeal fistula noted in 6.5%, 4.3%, and 4.3% of cases, respectively. In univariate analysis, none of the variables under analysis was related to the various significant complications noted and/or to immediate postoperative death. No patient had a permanent tracheotomy, whereas one had a permanent gastrostomy. Of the patients in whom a full course of radiation therapy was delivered postoperatively, 13.6% developed a major complication.ConclusionsFrom a functional point of view, lateral pharyngotomy is a safe, reliable surgery with few major complications and might be considered a valuable alternative to chemoradiation and/or mandibulotomy for selected tumors of the lateral oropharynx.Level of Evidence4 Laryngoscope, 123:2712–2717, 2013
Therapeutic Strategies to Prevent Alzheimer's Disease Pathogenesis Using A Fluorescent Conjugated Polyelectrolyte
Authors: Dwivedi Atul K. , Iyer Parameswar K. 
Published: July 2013

AbstractToxic metals accumulation in brain has a significant role in the pathogenesis of Alzheimer's disease (AD) by accelerating amyloid β (Aβ) peptide aggregation. Aβ has high affinity for iron and copper resulting in the generation of neurotoxic hydrogen peroxide, oxidative stress and free radical formation. Water–soluble conjugated polyfluorene derivative poly(9,9–bis(6–sulphate hexyl) fluorene–alt–1,4–phenylene) sodium salt (P1) binds Fe3+ heme proteins selectively in cerebrospinal fluid (CSF), including ferritin in the Aβ fibrils and diminishes their accumulation. Hence, therapeutic strategies involving clearance of Aβ from brain plaques, metal removal, structurally modifying the aggregates, and preventing them from aggregating again into toxic polypeptides are vital strategies to control AD pathogenesis.
Optimization of Photorefractivity Based on Poly(N‐vinylcarbazole) Composites: An Approach from the Perspectives of Chemistry and Physics
Authors: Kinashi Kenji , Wang Yu , Sakai Wataru , Tsutsumi Naoto 
Published: July 2013

AbstractThe optimization of photorefractivity (PR) based on a poly(N‐vinylcarbazole) (PVCz) composite devise is proposed from the perspectives of chemistry and physics. The device's PR chemistry (dependence of PVCz's molecular weight) and physics (dependence of grating periodicity and laser wavelength) are studied. Increasing the molecular weight of PVCz from 23 000 to 1 270 000 g mol−1 significantly increases diffraction efficiency, grating build‐up speed (inverse of response time), and sensitivity. Narrowing grating period from 5.1 to 1.1 μm gives faster response time and larger optical gain. Shorter wavelength of writing laser from 633 to 532 nm provides higher diffraction efficiency, faster response time, and larger optical gain.magnified image
Assessing apathy in everyday clinical practice with the short‐form Lille Apathy Rating Scale
Authors: Dujardin Kathy , Sockeel Pascal , Carette Anne‐Sophie , Delliaux Marie , Defebvre Luc 
Published: July 2013

ABSTRACTBackgroundApathy is an invalidating behavioral disorder that must always be screened for and assessed in patients with Parkinson's disease (PD). The Lille Apathy Rating Scale (LARS) has been validated in several different contexts, but the lengthy administration time means that it is mostly recommended for research use. The aim of the present study was to validate a short form of the LARS for use in everyday practice.MethodsIn total, 416 patients with PD and 56 healthy controls participated in the study. Apathy, depression, motor symptoms, and overall cognitive efficiency were assessed. The most discriminant items of the LARS for apathy detection were selected using multiple indicators.ResultsA subset of 12 items (constituting the short‐form LARS) showed the best convergence. Concurrent and criterion‐related validity, internal consistency, test‐retest reliability, and inter‐rater reliability were very good.ConclusionsThe short‐form LARS is a reliable, practical, patient interview‐based instrument for assessing apathy in everyday clinical practice. © 2013 International Parkinson and Movement Disorder Society
Theoretical and numerical study of the steady‐state flow through finite fractured porous media
Authors: Vu Minh‐Ngoc , Pouya Ahmad , Seyedi Darius M. 
Published: July 2013

SUMMARYThis paper investigates the two‐dimensional flow problem through an anisotropic porous medium containing several intersecting curved fractures. First, the governing equations of steady‐state fluid flow in a fractured porous body are summarized. The flow follows Darcy's law in matrix and Poiseuille's law in fractures. An infinite transversal permeability is considered for the fractures. A multi‐region boundary element method is used to derive a general pressure solution as a function of discharge through the fractures and the pressure and the normal flux on the domain boundary. The obtained solution fully accounts for the interaction and the intersection between fractures. A numerical procedure based on collocation method is presented to compute the unknowns on the boundaries and on the fractures. The numerical solution is validated by comparing with finite element solution or the results obtained for an infinite matrix. Pressure fields in the matrix are illustrated for domains containing several interconnected fractures, and mass balance at the intersection points is also checked. Copyright © 2013 John Wiley & Sons, Ltd.
Analysis of pile‐raft foundations under complex loads in layered soils
Authors: Mu Linlong , Huang Maosong , Lian Kenan 
Published: July 2013

SUMMARYConsidering there is hardly any concerted effort to analyze the pile‐raft foundations under complex loads (combined with vertical loads, horizontal loads and moments), an analysis method is proposed in this paper to estimate the responses of pile‐raft foundations which are subjected to vertical loads, horizontal loads and moments in layered soils based on solutions for stresses and displacements in layered elastic half space. Pile to pile, pile to soil surface, soil surface to pile and soil surface to soil surface interactions are key ingredients for calculating the responses of pile‐raft foundations accurately. Those interactions are fully taken into account to estimate the responses of pile‐raft foundations subject to vertical loads, horizontal loads and moments in layered soils. The constraints of the raft on vertical movements, horizontal movements and rotations of the piles as well as the constraints of the raft on vertical movements and horizontal movements of the soils are considered to reflect the coupled effect on the raft. The method is verified through comparisons with the published methods and FEM. Then, the method is adopted to investigate the influence of soil stratigraphy on pile responses. The study shows that it is necessary to consider the soil non‐homogeneity when estimating the responses of pile‐raft foundations in layered soils, especially when estimating the horizontal responses of pile‐raft foundations. The horizontal loads and the moments have a significant impact on vertical responses of piles in pile‐raft foundations, while vertical loads have little influence on horizontal responses of piles in pile‐raft foundations in the cases of small deformations. The proposed method can provide a simple and useful tool for engineering design. Copyright © 2013 John Wiley & Sons, Ltd.
Psychometric testing of the self‐care of heart failure index version 6.2
Authors: Vellone Ercole , Riegel Barbara , Cocchieri Antonello , Barbaranelli Claudio , D'Agostino Fabio , Antonetti Giovanni , Glaser Dale , Alvaro Rosaria 
Published: July 2013

AbstractThe Self‐Care of Heart Failure Index Version 6.2 (SCHFI v.6.2) is widely used, but its psychometric profile is still questioned. In a sample of 659 heart failure patients from Italy, we performed confirmatory factor analysis (CFA) to test the original construct of the SCHFI v.6.2 scales (Self‐Care Maintenance, Self‐Care Management, and Self‐Care Confidence), with limited success. We then used exploratory factor analysis to determine the presence of separate scale dimensions, followed by CFA in a separate sub‐sample. Construct validity of individual scales showed excellent fit indices: CFI = .92, RMSEA = .05 for the Self‐Care Maintenance Scale; CFI = .95, RMSEA = .07 for the Self‐Care Management Scale; CFI = .99, RMSEA = .02 for the Self‐Care Confidence scale. Contrasting groups validity, internal consistency, and test‐retest reliability were supported as well. This evidence provides a new understanding of the structure of the SCHFI v.6.2 and supports its use in clinical practice and research. © 2013 Wiley Periodicals, Inc. Res Nurs Health 36: 500–511, 2013