bluuebunny/crossref_metadata_2025_split huggingface dataset:
Venkat Ramaswamy – how value co-creation with stakeholders is transformative for producers, consumers and society
Authors: Leavy Brian 
Published: January 2014

Purpose
– This second part of Strategy & Leadership's interview with Prof. Venkat Ramaswamy, one of the early proponents of co-creating value with stakeholders, asks him about the progress of the “co-creation transformation” of markets on its tenth anniversary and its wider implications for firm strategists and public policy makers. The interview concludes with a remembrance of the late C.K. Prahalad, a co-developer of the theory, and reviews his many contributions to the advancement of strategic management.

Design/methodology/approach
– This interview considers how the co-creation view starts with interactions as the locus of value and platforms of engagements with individuals as the locus of value creation.

Findings
– The co-creation paradigm is a dynamic perspective that sees the interaction of customers, employees and other stakeholders as forums for learning and ever-expanding capability building.

Practical implications
– Strategy as “stretch and leverage” in the world of co-creation becomes about joint aspirations>joint resources.

Originality/value
– Corporate managers need to understand that leading companies that have successfully adopted the co-creation model follow a simple principle – they focus their entire organization on the engagements with individuals.
Misrecognition and Political Agency. The Case of Muslim Organisations in a General Election
Authors: Dobbernack Jan , Meer Nasar , Modood Tariq 
Published: January 2014

Research Highlights and Abstract This article: Examines the meaning of claims for ‘recognition’ and struggles against ‘misrecognition’ by working through aspects of Muslim political agency in contemporary British politics; Contributes to research on the political mobilisation of Muslims in Britain by examining how civil society organisations respond to perceived stigmas and project a Muslim civic identity; Contributes to research that investigates dilemmas of political agency between the pressure to conform to standards of neutrality and maturity, on the one hand, and creativity and opposition, on the other; Demonstrates how minority actors manoeuvre and position themselves in the unsettled environment of contemporary British politics. It is a common complaint among Muslim civil society organisations that their presence in British politics is misconstrued. An increasing number of activists and groups are concerned to repudiate what they perceive to be the misperception of their political agency as exceptional and difficult to accommodate. Organisations and initiatives thus project and practice civic identities, to demonstrate that they are committed to the ‘common good’. This article explores how a number of organisations positioned themselves in response to experiences of ‘misrecognition’ in the context of the General Election 2010. With this conceptual focus we explore one of the most pertinent characteristics of Muslim political agency in Britain today: how actors respond to perceived pressures, make claims and project identities in opposition to alleged misperceptions or the refusal to acknowledge their desired self-descriptions. The article draws on a set of qualitative interviews with representatives of advocacy organisations that mobilised Muslim constituents in the run-up to the General Election 2010.
Quenching Australia's thirst: A trend analysis of water‐based beverage sales from 1997 to 2011
Authors: Levy Gina S. , Shrapnel William S. 
Published: January 2014

AbstractAimTo show trends in sales of sugar‐sweetened and non‐sugar water‐based beverages in Australia over a 15‐year period.MethodsData were obtained from grocery sales surveys and adjusted to yield total market sales. Trends were examined using regression analysis both in absolute terms and per head. Home scan data were used to evaluate patterns of carbonated soft drink purchase according to income and household structure. Usage patterns by age and sex were also assessed.ResultsSales of non‐alcoholic, water‐based beverages grew at a rate of 1.7% per annum, driven largely by sales of non‐sugar varieties (4.9% per annum) with a smaller contribution from sugar‐sweetened beverages (0.3% per annum). Volume share of non‐sugar increased from 30 to 42% over the 15‐year period, while sugar sweetened showed sustained loss of share. Sales of sugar‐sweetened carbonated soft drinks fell over 15 years at a rate of 0.7% per annum, with a drop in volume share of 18%. Still water, energy and sports drinks showed persistent growth. Sugar contribution from water‐based beverages and soft drinks fell from 9.2 to 7.6 kg per person and from 8.4 to 6.2 kg per person, respectively. Soft drinks, energy drinks and sports drinks were most popular with teenagers and young adults, but not with older individuals. Low‐income households purchased less soft drinks compared to middle‐ and high‐income households.ConclusionsThe water‐based beverage category is undergoing a fundamental shift from sugar‐sweetened to non‐sugar drinks. The consequent fall in the sugar contribution from water‐based beverages, and soft drinks in particular, is consistent with public health objectives.
C‐Reactive protein and soluble intracellular adhesion molecule‐1 are related to pulse wave reflection in type 1 diabetes 在1型糖尿病中C‐反应蛋白以及可溶性细胞间黏附分子在1与脉冲波反射有关
Authors: Rogowicz‐Frontczak Anita , Pilacinski Stanislaw , Araszkiewicz Aleksandra , Zozulinska‐Ziolkiewicz Dorota , Wykretowicz Andrzej , Wierusz‐Wysocka Bogna 
Published: January 2014

AbstractBackgroundThe association of inflammation with cardiovascular (CV) complications in diabetes remains a matter of considerable debate. Arterial stiffness and enhanced wave reflection play an important role in CV complications. Therefore, in the present study we investigated whether markers of inflammation are correlated with parameters of wave reflection in type 1 diabetes (T1D).MethodsIn all, 145 T1D patients were included in the study (median age 32 years, disease duration 10 years, HbA1c 8.2%). Serum concentrations of high‐sensitivity C‐reactive protein (hs‐CRP), matrix metalloproteinase (MMP)‐9, soluble intracellular adhesion molecule‐1 (sICAM‐1), and myeloperoxidase (MPO) were estimated as markers of inflammation. Parameters of pulse wave reflection (central augmentation index [cAIx] and peripheral augmentation index [pAIx]) were assessed using pulse wave analysis.ResultsMultivariate linear regression analysis revealed that, after adjustment for age, mean blood pressure, HbA1c, low‐density lipoprotein–cholesterol, and the presence of at least one microangiopathic complication of diabetes, cAIx and pAIx were associated with serum concentration of hs‐CRP (β = 1.838, 95% confidence interval [CI] 0.336–3.339 [P = 0.017]; and β = 2.041, 95% CI 0.683–3.400 [P = 0.004], respectively) and sICAM‐1 (β = 0.073, 95% CI 0.015–0.131 [P = 0.014]; and β = 0.066, 95% CI 0.013–0.119 [P = 0.016], respectively) in the study group.ConclusionsIn T1D parameters of wave reflection are related to markers of inflammation.
Breast irradiation causes pallor in the nipple‐areolar complex in women with Celtic skin type (result from the St. George and Wollongong randomised breast boost trial)
Authors: Lee Yoo Young (Dominique) , Hau Eric , Browne Lois H , Chin Yaw , Lee Jessica , Szwajcer Alison , Cail Stacy , Nolan David N , Graham Peter H 
Published: January 2014

AbstractIntroductionThe nipple‐areolar complex (NAC) has special histological properties with higher melanocyte concentration than breast skin. To date, there are no data describing the late effects on the NAC following breast‐conserving therapy (BCT). This study evaluated colour changes in the NAC in patients treated with breast‐conserving surgery and adjuvant radiotherapy after 5 years.MethodsDigital photographs obtained at 5 years following breast irradiation from the St. George and Wollongong (SGW) trial (NCT00138814) were evaluated by five experts using an iPad® (Apple Inc., Cupertino, CA, USA) application specifically created for this study. The SGW trial randomised 688 patients with Tis‐2, N0‐1, M0 carcinoma to the control arm of 50 Gy in 25 fractions and boost arm of 45 Gy in 25 fractions and 16 Gy in 8 fractions electron boost.ResultsA total of 141/372 (38%) patients had altered NAC (86% lighter, 10% darker). Patients with Celtic skin type had increased likelihood of having an altered NAC (odds ratio (OR), 1.75 (CI 1.1–2.7, P = 0.011)). On subgroup analysis, those with Celtic skin type receiving biologically equivalent dose (BED) Gy3 ≥ 80 Gy had OR of 3.03 (95% CI 1.2–7.5, P = 0.016) for having altered colour. There was a dose response with more profound changes seen in the NAC compared with irradiated breast skin if BED Gy3 ≥ 80 Gy with OR of 2.42 (95% CI 1.1–5.6, P = 0.036).ConclusionIn this Caucasian BCT population, over 30% of patients developed lighter NAC and more commonly in women with Celtic skin type. The degree of this effect increased with higher radiation dose.
Ethanol Induces Conditioned Social Preference in Male Mice
Authors: Kent Kelly , Butler Kaelan , Wood Ruth I. 
Published: January 2014

BackgroundAffiliative social interactions promote alcohol consumption, and alcohol also promotes affiliative behavior. Furthermore, for most species, moderate doses of ethanol (EtOH) and social affiliation are each rewarding. However, animal studies of drug and EtOH reward typically test individuals in isolation. To address social dimensions of EtOH reward, this study tested EtOH‐induced conditioned social preference in male C57BL/6 mice with (ORCHX+T) and without (ORCHX) testosterone.MethodsORCHX+T males received EtOH (0, 1, 2, or 3 g/kg) intraperitoneally and were paired 4× for 30 minutes each with 1 of 2 stimulus males: with the CS− stimulus male after saline injection and with the CS+ male following EtOH. After pairing, time spent with CS+ and CS− males was measured in a 10‐minute test.ResultsORCHX+T test males showed conditioned preference for the CS+ male in response to 3 g/kg EtOH (change in preference: +71.3 ± 30.0 s/10 min, p < 0.05), but not for 0, 1, or 2 g/kg. By contrast, ORCHX males did not demonstrate conditioned preference for 3 g/kg EtOH (+16.0 ± 24.3 s/10 min, p > 0.05). In separate groups of mice, stimulus males (IS+) received EtOH during pairing to determine whether test mice prefer another intoxicated mouse. Both ORCHX+T and ORCHX test mice showed an increase in preference score for the IS+ mouse (ORCHX+T: +68.1 ± 24.0 seconds; ORCHX: +58.9 ± 19.6 seconds, p < 0.05).ConclusionsThese data demonstrate that EtOH promotes social preference in male mice, as it does in females. Testosterone enhances this effect.
Would legalizing illicit opioids reduce overdose fatalities? Implications from a natural experiment
Authors: Darke Shane , Farrell Michael 
Published: January 2014

AbstractOverdose is the leading cause of premature mortality among heroin users. We examine whether the provision of regulated and quality‐controlled heroin to users in specified doses would reduce heroin overdose rates. We also address this in the context of the epidemic of prescription opioid use and deaths seen in recent years in theUnited Statesand internationally. We explore the extent to which any change in legal access to heroin would affect overdose rates, and note that this depends upon the validity of the two main assumptions that variations in illicit drug purity and/or the presence of drug contaminants are major causes of overdose. Toxicological and demographic data from studies of heroin overdose deaths do not support these assumptions. The surge in the use of pharmaceutical opioids provides an example of the legal delivery of opioids of known dosage and free of contaminants, where overdose deaths can be examined to test these assumptions. Rates of fatal opioid overdose have escalated, with increased rates of prescribing of pharmaceutical opioids. On the basis of the experience with prescription opioids, unregulated legal heroin access would not reduce overdose rates.
Diagnosis and management of a maxillary lateral incisor exhibiting dens invaginatus and dens evaginatus
Authors: Akers Harry Francis , Henderson Carolyn Mary , Foley Michael Anthony 
Published: January 2014

AbstractThis case report, involving an indigenous Australian, presents the diagnosis and non‐surgical endodontic management of a 22 with developmental abnormalities. They include a dens evaginatus and a dens invaginatus that extends to an apical burst in a second truncated root. Cone‐beam computed tomography and endodontic microscopy were not available to the clinician. This case report focuses on ambiguities appearing in the literature relating to classification and terminology associated with the abovementioned developmental anomalies. It also demonstrates the need to methodically collect and cautiously interpret available information before initiating endodontic intervention. Axial inclination, distance perception, internal demarcation and spatial awareness, together with an understanding of dental anatomy, embryology and histology and associated physiology and pathology, allowed the clinician to accurately predict the point, the angle and the depth of coronal access. Sensibility of the dentino‐pulpal complex was maintained. Critical thinking, experience, innovation, problem‐solving and established principles can compensate for inaccessible technologies.
Preperimetric normal tension glaucoma study: long‐term clinical course and effect of therapeutic lowering of intraocular pressure
Authors: Jeong Jae Hoon , Park Ki Ho , Jeoung Jin Wook , Kim Dong Myung 
Published: January 2014

AbstractPurposeThe purpose of this study was to investigate the long‐term clinical course of normotensive preperimetric glaucoma (PPG).MethodsThe medical records of 71 eyes of 71 patients with normotensive PPG who underwent intraocular pressure (IOP)‐lowering therapy were reviewed retrospectively. The patients had been regularly followed up at 3‐ to 6‐month intervals between 1996 and 2011. Progression was evaluated by comparing the structural changes of serial stereoscopic colour disc and red‐free retinal nerve fibre layer (RNFL) photographs and by comparing serial visual field (VF) test results for functional changes.ResultsOver an average follow‐up period of 6.8 years, 41 eyes (57.7%) showed progression in either structural or functional evaluation. Disc haemorrhage (DH) was observed significantly more frequently in the progressing group (p < 0.005); however, there were no differences in mean age, gender ratio, follow‐up period and ocular characteristics at baseline such as IOP, RNFL defects and global indices of VF between the non‐progressing and progressing groups. Thirty eyes (42.3%) showed significant angular widening of the localized RNFL defect towards the macula at a mean rate of approximately 1°/year. Perimetric glaucoma developed in 19 eyes (26.8%), and the rate of change in the mean deviation was −0.23 dB/year. Preperimetric glaucoma patients with DH or IOP reductions of <20% from the baseline had a higher probability of RNFL deterioration than patients without DH or IOP reductions of ≥20% from the baseline by multivariate analysis.ConclusionAlthough the rates of change were typically slow, more than half of normotensive patients with PPG showed statistically significant progressive structural or functional changes in medically treated cases. DH or IOP reductions of <20% from the baseline were shown as a significant risk factor for the progression of PPG.
Visual field loss in optic disc drusen patients correlates with central retinal artery blood velocity patterns
Authors: Abegão Pinto Luís , Vandewalle Evelien , Marques‐Neves Carlos , Stalmans Ingeborg 
Published: January 2014

AbstractPurpose(1) To characterize the retrobulbar circulation in patients with optic disc drusen (ODD) using colour Doppler imaging; (2) to explore the differences in retrobulbar hemodynamics in patients with primary open‐angle glaucoma (POAG).MethodsRetrospective analysis using three diagnostic groups: patients with ODD, age‐matched healthy controls and age‐ and visual defect‐matched patients with POAG. Subjects with history of ocular trauma or ocular diseases including vascular‐related diseases were excluded. Kruskal–Wallis and Spearman's correlation tests were performed to compare and explore the correlations between the hemodynamic parameters and visual field damage.ResultsSixty patients were included and equally divided between the three groups. Patients with ODD had lower systolic and diastolic flow velocities in the central retinal artery (CRA) when compared to healthy individuals, but no difference was found with the glaucoma group (p < 0.005 versus healthy; p range 0.30–0.37 versus POAG). The systolic shift in flow patterns correlated with the extent of visual field defect in ODD patients (p < 0.001, r = −0.78, confidence interval: −0.43 to −0.92), but not in POAG (p = 0.73). Short ciliary arteries from ODD patients had lower mean systolic flow velocities when compared to both healthy individuals and patients with POAG (p < 0.01 versus healthy; p ≤ 0.04 versus POAG). The ophthalmic artery in ODD group had significantly higher mean blood velocities than in the POAG (p = 0.04), while showing a significant overlap in Doppler waveform variables to the control group (p range 0.08–0.97).ConclusionsSimilar to patients with glaucoma, individuals with ODD have low blood flow velocities in the vessels around the optic nerve head. Unlike patients with glaucoma, however, their CRA's blood flow velocity patterns correlate with the extent of the visual field defects.
Depression as a mediator of negative cognitive style and hopelessness in stress generation
Authors: Kleiman Evan M. , Liu Richard T. , Riskind John H. , Hamilton Jessica L. 
Published: January 2014

Over the past 20 years, there has been considerable interest in the role of cognitive factors in the stress generation process. Generally, these studies find that depressed individuals, or individuals at cognitive risk for depression, are more likely to experience stressful life events that are in part influenced by their own characteristics and behaviours (i.e., negative dependent events). However, there is still much to be learnt about the mediators of these effects. For example, does the development of depression symptoms explain why individuals at cognitive risk for depression experience increased negative dependent events? Or, is it that increases in cognitive risk explain why depressed individuals experience increased negative dependent events? To explore these questions, a short‐term prospective study was conducted with 209 college students who were given measures of depression, depressogenic risk factors (i.e., negative cognitive style and hopelessness), and negative dependent events at two time points 6 weeks apart. Support was found for three models: (1) depression symptoms mediated the relationship between negative cognitive style and negative dependent events; (2) depression symptoms mediated the relationship between hopelessness and negative dependent events; and (3) first hopelessness and then depression symptoms mediated the relationship between negative cognitive style and negative dependent events in a multiple‐step model. In contrast, the reverse models were not confirmed, suggesting specificity in the direction of the mediational sequence.
PRC1 components exhibit different binding kinetics in Polycomb bodies
Authors: Vandenbunder Bernard , Fourré Nicolas , Leray Aymeric , Mueller Florian , Völkel Pamela , Angrand Pierre‐Olivier , Héliot Laurent 
Published: January 2014

Background InformationPolycomb group (PcG) proteins keep the memory of cell identity by maintaining the repression of numerous target genes. They accumulate into nuclear foci called Polycomb bodies, which function in Drosophila cells as silencing compartments where PcG target genes convene. PcG proteins also exert their activities elsewhere in the nucleoplasm. In mammalian cells, the dynamic organisation and function of Polycomb bodies remain to be determined.ResultsFluorescently tagged PcG proteins CBXs and their partners BMI1 and RING1 form foci of different sizes and intensities in human U2OS cells. Fluorescence recovery after photobleaching (FRAP) analysis reveals that PcG dynamics outside foci is governed by diffusion as complexes and transient binding. In sharp contrast, recovery curves inside foci are substantially slower and exhibit large variability. The slow binding component amplitudes correlate with the intensities and sizes of these foci, suggesting that foci contained varying numbers of binding sites. CBX4‐green fluorescent protein (GFP) foci were more stable than CBX8‐GFP foci; yet the presence of CBX4 or CBX8‐GFP in the same focus had a minor impact on BMI1 and RING1 recovery kinetics.ConclusionWe propose that FRAP recovery curves provide information about PcG binding to their target genes outside foci and about PcG spreading onto chromatin inside foci.
Midkine: an emerging target of drug development for treatment of multiple diseases
Authors: Muramatsu Takashi , Kadomatsu Kenji 
Published: January 2014

Midkine is a multifunctional factor and has anti‐apoptotic, migration‐promoting, angiogenic, anti‐microbial and other activities. Midkine ameliorates ischemic injury in the heart and brain, enhances oocyte maturation, and is involved in neurogenesis. On the other hand, midkine is an important factor in the etiology of various diseases, especially those with inflammatory backgrounds. Furthermore, midkine is overexpressed in most malignant tumors and plays roles in their invasive phenotypes as well as in their resistance to chemotherapeutics. Therefore, midkine itself is expected to be useful for the treatment of brain and heart diseases, while midkine inhibitors are promising for the treatment of malignant tumors, multiple sclerosis, restenosis, renal diseases, hypertension and osteoporosis. Blood levels of midkine are also expected to be helpful as disease markers, especially as cancer markers.Linked ArticlesThis article is part of a themed section on Midkine. To view the other articles in this section visit http://dx.doi.org/10.1111/bph.2014.171.issue‐4
Partial 3‐D Correspondence from Shape Extremities
Authors: Sahillioğlu Y. , Yemez Y. 
Published: January 2014

AbstractWe present a 3‐D correspondence method to match the geometric extremities of two shapes which are partially isometric. We consider the most general setting of the isometric partial shape correspondence problem, in which shapes to be matched may have multiple common parts at arbitrary scales as well as parts that are not similar. Our rank‐and‐vote‐and‐combine algorithm identifies and ranks potentially correct matches by exploring the space of all possible partial maps between coarsely sampled extremities. The qualified top‐ranked matchings are then subjected to a more detailed analysis at a denser resolution and assigned with confidence values that accumulate into a vote matrix. A minimum weight perfect matching algorithm is finally iterated to combine the accumulated votes into an optimal (partial) mapping between shape extremities, which can further be extended to a denser map. We test the performance of our method on several data sets and benchmarks in comparison with state of the art.