bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acupuncture for rescue workers with post-traumatic stress disorder: A randomized controlled trail
Authors: Lu Xiaoguang , Luan Hengyu , Li Dongyao , Gong Rufang , Li Qiongxuan , Guan Ling , Sai Xiaoyong 
Published: July 2024

Abstract

Importance: Rescue workers are at high risk for post-traumatic stress disorder (PTSD) due to the high-intensity nature. Efficacy of acupuncture for PTSD has been reported. However, to date, there have been no reports of acupuncture interventions for rescue workers who screen positive for acute or chronic stress.
Objective: To evaluate the clinical efficacy and safety of acupuncture in treating rescue workers who screened positive for PTSD.
Design, setting, and participants: The PTSD Checklist for DSM-5 (PCL-5) and the Acute Stress Disorder Scale (ASDS) were used to screen 5098 high-stress rescue workers between June and August 2022, of which 149 screening positive. Sixty participants were randomly selected and divided into two groups. The control and treatment groups received psychodynamic therapy and acupuncture treatment, respectively, once a week for 6 weeks. Participants were blinded to their own grouping. The efficacy evaluators, subjects and statistical analysts were blinded.
Interventions: Weekly acupuncture or psychodynamic therapy for 6 weeks.
Main outcomes and measures: Scores on the PCL-5 and the ASDS were used as primary outcomes from baseline to 6 weeks. Any adverse effects and side effects experienced during the study were recoded.
Results: A total of 43 participants were enrolled (mean (P25, P75) age, 22(21, 25) years; 43 men [97.7%]) underwent randomization. The demographic and baseline characteristics were balanced between groups. After 6 weeks intervention, the ASDS and total PCL-5 scores of participants in both groups reduced significantly. Compared with the control group, acupuncture group resulted in a significantly greater decrease in scores. The between-group differences were -7.87(95%CI, -15.48 to -0.26; P=0.043) in the ASD score and -8.04(95%CI, -15.63to-0.46; P=0.038) in PCL score. There were no serious adverse events.
Conclusion and relevance: In this random clinical trial of rescue workers who screened positive for PTSD, acupuncture has been shown to serve as a safe and efficient early intervention. Acupuncture may be implemented before and after a disaster strikes in order to minimize mental health problems among rescue workers, and thus save as many lives as possible.
Trail registration: Chinese Clinical Trial Registry: ChiCTR1900023441.
Analysis of prognostic and predictive factors of isolated chest wall recurrence in breast cancer after mastectomy
Authors: Wang Yanrong , Gao Ming , Yan Huan , You Junhao , Ding Lijuan , Dai Guanghai , Zhang Xia 
Published: July 2024

Abstract

Objective: To investigate the clinical features, molecular subtypes, and factors influencing metastasis in patients with breast cancer chest wall metastasis.
Methods: We collected the clinical data of patients who developed isolated chest wall metastasis following radical surgery for breast cancer. The molecular subtypes of the primary lesions and secondary biopsy lesions in patients with chest wall metastasis were analyzed and summarized. The disease-free survival (DFS) after breast cancer surgery and its influencing factors were also documented.
Results: Of the 99 cases of isolated chest wall recurrence included in our study, DFS varied from 1 to 264 months, with a median DFS of 36 months. The 3-year disease-free survival rate was 44.6%, while the 5-year rate was 24.2%. Molecular subtype changes occurred in a total of 28 cases before and after metastasis, accounting for 34% of the cases. COX multivariate analysis revealed that pathological type, surgical staging, postoperative expression status of ER (estrogen receptor), PR (progesterone receptor), Ki-67, HER-2 (human epidermal growth factor receptor-2), and the receipt of adjuvant chemotherapy after surgery were independent factors affecting chest wall recurrence and metastasis.
Conclusion: Local recurrence after breast cancer surgery increases the risk of distant metastasis. Identifying high-risk factors for recurrence enables the tailoring of individualized comprehensive treatment plans based on the patient's condition, thus reducing the risk of local recurrence and improving survival outcomes.
Reactive Extrusion of Cellulose Esters in Ionic Liquid: Exploring Properties and Performance Across Different Cellulose Types and Degree of Polymerizations
Authors: Tarasova Elvira , Krasnou Illia , Enkhsaikhan Giiguulen , Abousharabia Ibrahim , Nunes Caio César Zandonadi , Karthegesu Darshni , Savale Nutan , Kontturi Eero , Krumme Andres 
Published: July 2024

Abstract

This study compares the efficacy of reactive extrusion and traditional reactor methods in altering cellulose structure to produce cellulose esters (CEs) with targeted properties. Ionic liquids (ILs) afford high cellulose solubility and recyclability, while chemical reactors enable complete cellulose dissolution and homogeneous transesterification. However, prolonged reaction times and potential oxidation issues necessitate further optimization. Conversely, reactive extrusion allows shorter reaction times, reduced solvent usage, and scalability. The current study aims to investigate how the type of cellulose (microcrystalline and fibrous) and its degree of polymerization (DP) affect the transesterification process and properties of CEs produced by reactive extrusion, as opposed to traditional methods. It was obtained that it is possible to produce cellulose laurates (CLs) with a degree of substitution (DS) of up to 2.5 via reactive extrusion. Examination of CLs obtained from the reactor (R-CLs) and reactive extrusion (REX-CLs) reveals structural properties diverging, with REX-CLs maintaining residual crystallinity despite esterification. Additionally, reactive extrusion produces CLs with lower molar mass (MM) due to a reduced DS, and in the case of fibrous celluloses, shear-induced degradation may occur. Cellulose DP emerges as pivotal for attaining desired thermal stability, with higher DP compounds displaying enhanced resistance to thermal degradation. Furthermore, reactive extrusion enhances the thermal stability of CLs compared to traditional methods. However, comparative rheological analysis reveals that REX-CLs exhibit higher complex viscosity and G-moduli values than R-CLs. This phenomenon suggests that the structural arrangement of REX-CLs promotes intermolecular interactions, contributing to increased viscosity and stiffness. Reactive extrusion in an ionic liquid environment shows promise for scaled-up production of CEs with tailored properties. This indicates its potential as a sustainable and efficient manufacturing method for cellulose-based materials.
Effect of nursing intervention based on resourcefulness theory on fertility anxiety of ovarian cancer patients
Authors: Yin Ping , Ding Xia , Li Wen-Hui , Qu Ping , Zhang Long-yu , LI Na 
Published: July 2024

Abstract

Objective: To explore the effect of nursing intervention based on resourcefulness theory on fertility anxiety of ovarian cancer patients.
Methods: 64 patients with ovarian cancer who were treated in hospital from May 2019 to September 2022 were selected as the study objects, and the patients were divided into control group and intervention group with 32 cases in each group by random number table. The control group was given routine nursing, and the intervention group was given nursing intervention based on the wisdom theory. The post-cancer fertility worry Scale, self-rating Depression Scale (SDS), self-rating Anxiety Scale (SAS), comprehensive Quality of Life questionnaire (GQOLI-74) and self-made nursing satisfaction questionnaire were used before and after intervention to evaluate the fertility worry, depression, anxiety, quality of life and nursing satisfaction of the two groups of patients.
Results: After intervention, the fertility worry score, SDS score and SAS score of the two groups were decreased, and the fertility worry score, SDS score and SAS score of the intervention group were lower than those of the control group (P<0.05). After intervention, the material life, social function, psychological function, physical function and GQOLI-74 total score of the intervention group were significantly improved compared with the control group, and the differences were statistically significant (P<0.05). The nursing satisfaction of intervention group was higher than that of control group (P<0.05).
Conclusion: Nursing intervention based on the wisdom theory can significantly reduce the fertility worries of ovarian cancer patients, relieve depression and anxiety, improve quality of life, and enhance nursing satisfaction, which is worthy of clinical reference and promotion.
Phase II clinical study of SRS combined with osimertinib in the treatment of EGFR positive non-small cell lung cancer with brain metastasis
Authors: wangti Xie , yu Wu , xiaoshan Cheng , jianbing Hu , fang Wen , jia Xiao , pan Luo , yuqi Su , xiang Yao , jianlong Fang , rong Dang , xianggan Huang , dunqian Liu , jie Weng 
Published: July 2024

Abstract

Objective
To observe the safety and efficacy of SRS synchronous osimertinib compared with osimertinib alone in the treatment of patients with brain metastasis of EGFR positive non-small cell lung cancer.
Methods Select the EGFR positive non-small cell lung cancer patients with brain metastasis admitted to our hospital from January 2018 to January 2020. The experimental group: 30 patients were treated with SRS combined with osimertinib. SRS treatment: prescription dose (d = 0-40mm, 27Gy/3f); Targeted treatment scheme: osimertinib, 80mg/day, taken orally after SRS treatment; Control group: 30 patients were treated with osimertinib alone; osimertinib was maintained until disease progression (PD) or adverse reactions were intolerable. PFS, ORR, DCR and AEs of intracranial lesions were observed.
Results This study plans to include 60 patients, with a median age of 54.8 (35–79) years, including 41 males and 19 females, with a median follow-up time of 34.5 (30–42) months; There were 30 cases in the experimental group and 30 cases in the control group, respectively. The ORR of intracranial lesions in the two groups were 96.67% and 66.67% respectively, with significant statistical difference between the two groups (p = 0.003); The DCR of intracranial lesions were 100% and 96.67% respectively, and there was no significant difference between the two groups (p = 0.313); The median PFS of intracranial lesions were 26.5 months and 16.5 months, respectively. There was a significant difference between the two groups (p < 0.001); The most common adverse event of radiotherapy was radioactive brain edema. The incidence of grade Ⅰ - Ⅱ in the experimental group was 43.33%. After treatment of intracranial pressure reduction, it improved, and no grade Ⅲ - Ⅳ radioactive brain edema occurred; The second adverse event was osimertinib Ⅰ - Ⅱ, mainly including diarrhea, rash, oral ulcer, etc.
Conclusions SRS synchronous osimertinib therapy is more effective than simple osimertinib in the treatment of brain metastasis of EGFR positive non-small cell lung cancer patients, and the side effects are tolerable. We look forward to further large phase III clinical studies to confirm it.
Trial Registration
This study was registered with China Clinical Trial Registration Center (www.chictr.org.cn, identifier:ChiCTR1900025626,Reg Date:2019/09/03)
Can Early Dietary Intervention Attenuate Weight Gain in Children Receiving Treatment for Graves’ disease?
Authors: Alradadi Rasha , Chen Melinda , Cleveland Jenniffer , Spears Nicole , Eugster Erica 
Published: July 2024

Abstract

Background:
Previous studies have demonstrated that many children become overweight following the treatment of Graves’ disease, regardless of the therapeutic modality used.
Objective:
To investigate whether dietary counseling early in the treatment course of Graves’ disease can mitigate the degree of subsequent weight gain.
Design: Prospective cohort study
Setting: Outpatient clinic at tertiary center
Subject and Methods:
Patients presenting with a new diagnosis of Graves’ disease were eligible for the study.
Children and their parents participated in a single session with a registered dietitian within 3 months of their initial visit. The content focused on the nutritional value of common foods, how to make healthy choices and what comprised an age-appropriate caloric intake. At each visit BMI z-scores were calculated.
Main outcome measures: Change in BMI SDS from baseline to the most recent clinic visit was determined.
Result:
Twenty-three patients (4 boys) aged 13.3 (2.8) years were enrolled. Twelve (52.2%) received radioactive iodine ablation, 3 (13 %) underwent thyroidectomy and 8 (34.9%) received methimazole. Of the 23 patients, 12 (52.2%) remained in the same weight category, 10 (43.5%) moved into a higher weight category and one (4.3 %) moved to a lower category. Mean BMI SDS was 0.53 (1.4) at baseline and 0.87 (1.2) at follow-up, p=0.3667. No differences were seen in the degree of weight gain by treatment group or gender (p= 0.095).
Conclusion:
No change in BMI SDS was observed ~two years after the treatment of Graves’ disease in our patients. Formal dietary consultations early in the treatment course represent an inexpensive intervention designed to prevent the excessive weight gain that often follows the treatment of Graves’s disease. Larger studies will be helpful in determining whether they should become part of the standard management of Graves’ disease in pediatric patients.
Limitation:
The small sample size and lack of a prospective control group. Instead, we used a published historical cohort followed at our institution as a comparator
Medaka liver developed Human NAFLD-NASH transcriptional signatures in response to ancestral bisphenol A exposure
Authors: Chakraborty Sourav , Anand Santosh , Bhandari Ramji Kumar 
Published: July 2024

Abstract

The progression of fatty liver disease to non-alcoholic steatohepatitis (NASH) is a leading cause of death in humans. Lifestyles and environmental chemical exposures can increase the susceptibility of humans to NASH. In humans, the presence of bisphenol A (BPA) in urine is associated with fatty liver disease, but whether ancestral BPA exposure leads to the activation of human NAFLD-NASH-associated genes in the unexposed descendants is unclear. In this study, using medaka fish as an animal model for human NAFLD, we investigated the transcriptional signatures of human NAFLD-NASH and their associated roles in the pathogenesis of the liver of fish that were not directly exposed, but their ancestors were exposed to BPA during embryonic and perinatal development three generations prior. Comparison of bulk RNA-Seq data of the liver in BPA lineage male and female medaka with publicly available human NAFLD-NASH patient data revealed transgenerational alterations in the transcriptional signature of human NAFLD-NASH in medaka liver. Twenty percent of differentially expressed genes (DEGs) were upregulated in both human NAFLD patients and medaka. Specifically in females, among the total shared DEGs in the liver of BPA lineage fish and NAFLD patient groups, 27.69% were downregulated, and 20% were upregulated. Of all DEGs, 52.31% of DEGs were found in ancestral BPA-lineage females, suggesting that NAFLD in females shared the majority of human NAFLD gene networks. Pathway analysis revealed beta-oxidation, lipoprotein metabolism, and HDL/LDL-mediated transport processes linked to downregulated DEGs in BPA lineage males and females. In contrast, the expression of genes encoding lipogenesis-related proteins was significantly elevated in the liver of BPA lineage females only. BPA lineage females exhibiting activation of myc, atf4, xbp1, stat4, and cancerous pathways, as well as inactivation of igf1, suggest their possible association with an advanced NAFLD phenotype. The present results suggest that gene networks involved in the progression of human NAFLD and the transgenerational NAFLD in medaka are conserved and that medaka can be an excellent animal model to understand the development and progression of liver disease and environmental influences in the liver.
Psychometric properties of the Patient Health Questionnaire (PHQ-9) in the Dominican Republic
Authors: Garcia-Batista Zoilo Emilio , Guerra-Peña Kiero , Alvarez-Hernandez Adriana Maria , CANO-VINDEL ANTONIO , Muñoz-Navarro Roger , Moretti Luciana Sofia , Espinal-Martinez Jairo , Medrano Leonardo 
Published: July 2024

Abstract

The PHQ-9 is a globally recognized and widely used tool for screening depression. Its importance lies in its ability to assess the DSM criteria for depressive disorders, allowing both diagnosis and assessment of the severity of the condition. However, despite its prevalence internationally, no comprehensive studies on its psychometric properties have been carried out in the Dominican Republic. This lack of reliable and valid psychometric instruments to assess depression entails several significant challenges. On the one hand, it limits diagnostic accuracy, which may result in incorrect or incomplete detection of depressive symptoms. In addition, it hinders proper assessment of the symptomatology and severity of the disorder, which could lead to inappropriate treatments. It also restricts the possibilities for research on depression in the specific context of the Dominican Republic, which hinders a complete understanding of the disease in terms of its cultural and social characteristics. To address this gap in the literature, this study set out to examine the psychometric properties of the PHQ-9 in the Dominican population. For this purpose, we relied on the participation of 1437 Dominicans. The results obtained provide favorable evidence on validity and reliability. In terms of internal structure, a unidimensional model was found to explain a significant proportion of the variability in the responses. In addition, confirmatory analyses showed an excellent fit of the proposed model. In terms of reliability, both McDonald's Omega coefficient and Cronbach's Alpha coefficient yielded values above the accepted threshold of 0.70, indicating adequate internal consistency. Likewise, a strong association was verified between the PHQ-9 and GAD-7 scores, providing additional evidence of criterion validity. These results support previous findings and suggest that the PHQ-9 is a reliable and valid tool to assess depression in the Dominican population.
Biomechanics and clinical outcomes of “barrel handle” connecting rods used in INFIX internal fixation for unstable pelvic fractures: a cadaveric biomechanical study and retrospective cohort study
Authors: Chen Hongfen , Wu Gen , Ma Sushuang , Li Yanbing , Zhong Hua 
Published: July 2024

Abstract

Background
This study aimed to compare the biomechanical stability and clinical outcomes of a bent “barrel handle” connecting rod with a conventional “arc” rod when using the anterior subcutaneous internal fixator (INFIX) for unstable pelvic fractures.
Method
Type C1 pelvic ring injury model specimens were created by performing sacral foramen and pubic ramus osteotomies in 16 cadaveric pelvises. The models were randomly divided into group A (INFIX S1 screw fixation using a “barrel handle” connecting rod) and group B (INFIX S1 screw fixation using an “arc” connecting rod). Each model underwent vertical loading of 200–800 N, and the horizontal and vertical displacement distances of the fractured ends of the pubic ramus were recorded at 200, 400, 600, and 800 N. The treatment outcomes of 37 patients with unstable pelvic fractures were retrospectively evaluated. Among these, 15 patients were treated with the INFIX using the “barrel handle” connecting rods, while 22 were treated with the INFIX using the “arc” connecting rod. Outcome measures were postoperative complications (ectopic ossification, anterior exothelial nerve injury, infection), fracture reduction quality (Matta score), and postoperative function (Majeed score).
Results
The experiments showed no significant differences between groups A and B in the horizontal and vertical displacements after vertical compression. Among the 39 clinical cases, two patients were lost to follow-up. The demographic characteristics (sex and age), fracture classification, Injury Severity Score, and body mass index of the two groups were not comparable (P > 0.05). There were no significant differences between the two groups in fracture reduction quality, postoperative function, and postoperative complications, except for ectopic ossification. The incidences of anterior exothelial nerve injury and wound infection were significantly lower in the group treated with the INFIX using the “barrel handle” connecting rod than in the group treated with the INFIX using the “arc” connecting rod.
Conclusion
The INFIX using a “barrel handle” connecting rod achieves similar biomechanical stability and favorable clinical outcomes compared with the INFIX using an “arc” connecting rod. Furthermore, use of the INFIX with “barrel handle” connecting rods significantly reduces the incidences of postoperative wound infection and anterior exocortical nerve injury.
Observation of floating surface state in obstructed atomic insulator candidate NiP2
Authors: Liu Chang , Liu Xiang-Rui , Zhu Mingyuan , Feng Yuanwen , Zeng Meng , Ma Xiaoming , Hao Yu-Jie , Dai Yue , Luo Ronghao , Yamagami Kohei , Liu Yi , Cui Shengtao , Sun Zhe , Liu Jiayu , Liu Zhengtai , Ye Mao , Shen Dawei , Li Bing 
Published: July 2024

Abstract

Obstructed atomic insulator is recently proposed as an unconventional material, in which electric charge centers localized at sites away from the atoms. A half-filling surface state would emerge at specific interfaces cutting through these charge centers and avoid intersecting any atoms. In this article, we utilized angle-resolved photoemission spectroscopy and density functional theory calculations to study one of the obstructed atomic insulator candidates, NiP2. A floating surface state with large effective mass that is isolated from all bulk states is resolved on the (100) cleavage plane, distinct from previously reported surface states in obstructed atomic insulators that are merged into bulk bands. Density functional theory calculation results elucidate that this floating surface state is originated from the obstructed Wannier charge centers, albeit underwent surface reconstruction that splits the half-filled obstructed surface state. Our findings not only shed lights on the spectroscopy study of obstructed atomic insulators and obstructed surface states, but also provide possible route for development of new catalysts.