bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simple and robust monitoring of ethanol fermentations by capillary electrophoresis
Authors: Oliver James D. , Sutton Adam T. , Karu Naama , Phillips Michael , Markham Julie , Peiris Paul , Hilder Emily F. , Castignolles Patrice 
Published: July 2014

AbstractFree‐solution capillary electrophoresis (CE), or capillary zone electrophoresis, with direct UV detection was used for the first time for the determination of mono‐ and disaccharides, sugar alcohols, and ethanol in fermentation broths. Sample preparation proved to be minimal: no derivatization or specific sample purification was needed. The CE conditions can be adapted to the type of fermentation by simply altering the background electrolyte (BGE). KOH (130 mM) or NaOH (130 mM) as the BGE led to the fastest analysis time when monitoring simple fermentations. A mixture of 65 mM NaOH and 65 mM LiOH led to a 19% improvement in resolution for a complex mixture of carbohydrates. Quantification of a simple carbohydrate fermentation by CE showed values in close agreement with that of high‐performance anion exchange chromatography and high‐performance liquid chromatography (HPLC) on a cation exchange resin. For complex fermentations, quantification of carbohydrates by HPLC and CE led to similar results, whereas CE requires an injection volume of only 10–20 nL. Analysis of an ethanol fermentation of hydrolyzed plant fiber demonstrated the robustness of the separation and detection of carbohydrates, as well as ethanol. Ethanol determination is achieved by coupling the CE method to pressure mobilization, using the same instrument and the same sample.
Luminescence and spectroscopic studies of halosulfate phosphors: a review
Authors: Gedam S. C. , Thakre P. S. , Dhoble S. J. 
Published: July 2014

ABSTRACTThis review discusses the photoluminescence (PL) characteristics of halosulfate phosphors developed by us. Halosulfate phosphors KCaSO4Cl:X,Y (X = Eu or Ce; Y = Dy or Mn) and Na6(SO4)2FCl (doped with Dy, Ce or Eu) were prepared using a solid‐state diffusion method. The mechanism of energy transfer from Eu2+→Dy3+, Ce3+→Dy3+ and Ce3+→Mn2+ has also been studied. Dy3+ emission in the host at 475 and 570 nm is observed due to 4F9/2→6H15/2 and 4F9/2→6H13/2 transition, whereas the PL emission spectra of Na6(SO4)2FCl:Ce phosphor shows Ce3+ emission at 322 nm due to 5d→4f transition of the Ce3+ ion. The main property of KCaSO4Cl is its very high sensitivity, particularly when doped by Dy, Mn or Pb activators. This review also discusses the PL characteristics of some new phosphors such as LiMgSO4F, Na6Pb4(SO4)6Cl2, Na21Mg(SO4)10Cl3 and Na15(SO4)5F4Cl. Copyright © 2014 John Wiley & Sons, Ltd.
New Derivatives of Nonactic and Homononactic Acids from Bacillus pumilus Derived from Breynia fruticosa
Authors: Han Li , Huo Peiyuan , Chen Huahong , Li Songtao , Jiang Yi , Li Liya , Xu Lihua , Jiang Chenglin , Huang Xueshi 
Published: July 2014

AbstractSix new nonactic and homononactic acid derivatives, ethyl homononactate (1), ethyl nonactate (2), homononactyl homononactate (6), ethyl homononactyl nonactate (7), ethyl homononactyl homononactate (8), and ethyl nonactyl nonactate (9), as well as four known compounds, homononactic acid (3), nonactic acid (4), homononactyl nonactate (5), and bishomononactic acid (10), were isolated from culture broth of Bacillus pumilus derived from Breynia fruticosa. The structures of new compounds were elucidated by spectroscopic analysis and chemical methods. The optical purities of 1–6 were determined by HPLC/MS after treatment with L‐phenylalanine methyl ester. The dimeric compounds 5–9 showed weak cytotoxic activities against five human cancer cell lines (IC50 19–100 μg/ml).
Suppression of Inflammatory Cytokine Production by ar‐Turmerone Isolated from Curcuma phaeocaulis
Authors: Oh Sera , Han A Rheum , Park Hye Ryeon , Jang Eun Jung , Kim Hyo Kyeong , Jeong Mi Gyeong , Song Hyuna , Park Gun Hwa , Seo Eun Kyoung , Hwang Eun Sook 
Published: July 2014

AbstractRhizomes of Curcuma phaeocaulis Valeton (Zingiberaceae) have traditionally been used for controlling inflammatory conditions. Numerous studies have aimed to isolate and characterize the bioactive constituents of C. phaeocaulis. It has been reported that its anti‐inflammatory properties are a result of cyclooxygenase‐2 inhibition; however, its effect on the T‐cell function remains to be elucidated. In this study, four known sesquiterpenoids, viz., ar‐turmerone (TM), germacrone (GM), (+)‐(4S,5S)‐germacrone‐4,5‐epoxide (GE), and curzerenone (CZ), were isolated from C. phaeocaulis rhizomes and evaluated for their effects on the CD4+ T‐cell function. While GM, GE, and CZ had no effect on the activation of splenic T cells or CD4+ T cells, TM suppressed the interferon (IFN)‐γ production, without affecting the interleukin (IL)‐4 expression. TM also decreased the expression of IL‐2 in CD4+ T cells, but did not change their cell‐division rates upon stimulation. These results suggest that TM, a major constituent of C. phaeocaulis rhizomes selectively exerts potent anti‐inflammatory effects via suppression of the inflammatory cytokines IFN‐γ and IL‐2.
MKP‐1 is a target of miR‐210 and mediate the negative regulation of miR‐210 inhibitor on hypoxic hPASMC proliferation
Authors: Jin Youpeng , Pang Tingting , Nelin Leif D. , Wang Wei , Wang Yulin , Yan Jinchun , Zhao Chun 
Published: July 2014

AbstractChonic hypoxia, smooth muscle cell (SMC) proliferation and vascular remodeling are hallmark features of pathogenic pulmonary artery hypertension. MicroRNAs (miRNAs), endogenously expressed small noncoding RNAs, regulate gene expression at the post‐transcriptional level. MiR‐210 is considered a “master miRNA” in the control of diverse functions in hypoxic cells and tissues and has a cytoprotective function in pulmonary artery SMCs during hypoxic stress. MiR‐210 is also upregulated in lung tissue of chonically hypoxic mice suffering from pulmonary hypertension. Jin et al. () showed that mice deficient in mitogen‐activated protein kinase phosphatase 1 (MKP‐1) had severe hypoxia‐induced pulmonary hypertension, so MKP‐1 may be important in the progression of hypoxic pulmonary artery hypertension. We investigated the possible interactions between miR‐210 and MKP‐1 and the effect on cell proliferation in hypoxic human pulmonary artery SMCs (hPASMCs). miR‐210 was significantly increased in cultured hPASMCs exposed to 1% O2 hypoxia for 48 h, as was MKP‐1 mRNA and protein expression. Furthermore, inhibiting miR‐210 expression increased MKP‐1 mRNA and protein expression in hPASMCs and decreased cell proliferation under hypoxia. Conversely, overexpressing miR‐210 prevented hypoxia‐induced MKP‐1 expression with no effect on cell proliferation. siRNA knockdown of MKP‐1 abolished the miR‐210‐inhibition prevention of cell proliferation under hypoxia. MKP‐1 is a target of miR‐210 and could mediate the negative regulation of miR‐210 inhibition on hypoxic hPASMCs.
Nano‐ and Microscale Engineering of the Molybdenum Disulfide‐Based Catalysts for Syngas to Ethanol Conversion
Authors: Konarova Muxina , Tang Fengqiu , Chen Jiuling , Wang Geoff , Rudolph Victor , Beltramini Jorge 
Published: July 2014

AbstractNickel‐promoted MoS2, unsupported catalysts and laponite‐supported alcohol synthesis catalysts were synthesised by using microemulsion (ME) and hydrothermal (HT) methods. Highly ordered sulfide slabs, consisting of up to seven layers, were visible in the TEM images of HT‐based NiMoS2 catalysts. In contrast, disordered sulfide layers were identified in ME‐based NiMoS2 catalysts. High catalytic activity was observed in ME‐based supported (laponite‐supported NiMoS2) and unsupported catalysts. After the CO hydrogenation reaction, the catalysts were characterised by X‐ray photoelectron spectroscopy and inductively coupled plasma–mass spectrometry elemental analyses, which detected a significant sulfur loss in ME‐based NiMoS2 catalysts and minor sulfur loss in HT‐based NiMoS2 catalysts. In addition to the large surface area (120 m2 g−1), disordered sulfide structure, and exposed active sites, ME‐based NiMoS2 catalysts demonstrated higher alcohol selectivity (61 mol %) than HT‐based NiMoS2 catalysts (15 mol %). Correlations between the catalyst morphology, surface active components, and alcohol selectivity are discussed herein.
Shape‐Dependent Electrocatalysis: Oxygen Reduction on Carbon‐Supported Gold Nanoparticles
Authors: Erikson Heiki , Sarapuu Ave , Tammeveski Kaido , Solla‐Gullón Jose , Feliu Juan M. 
Published: July 2014

AbstractCubic, octahedral and quasi‐spherical (two different particle sizes) Au nanoparticles are synthesised and dispersed in a carbon‐black powder. The size and morphology of the Au nanocatalysts is confirmed by transmission electron microscopy and X‐ray diffraction. Au nanospheres are approximately 5 and 30 nm in diameter, whereas the size of Au octahedra and nanocubes is approximately 40–45 nm. The electrocatalytic activity of these carbon‐supported particles towards the oxygen reduction reaction (ORR) is studied in 0.5 M H2SO4 and 0.1 M KOH solutions by using the rotating‐disk‐electrode method. The specific activity (SA) for O2 reduction is measured, and the highest SA is observed for Au nanocubes supported on carbon. The highest mass activities are found for the smallest Au nanoparticles. Tafel analysis suggests that the mechanism of the ORR on shape‐controlled Au/C catalysts is the same as on bulk Au.
Effects of Redox Mediators on the Catalytic Activity of Iron Porphyrins towards Oxygen Reduction in Acidic Media
Authors: He Qinggang , Wu Gang , Liu Ke , Khene Samson , Li Qing , Mugadza Tawanda , Deunf Elise , Nyokong Tebello , Chen Shaowei W. 
Published: July 2014

AbstractThe effects of different redox mediators on the oxygen reduction reaction (ORR) catalyzed by an iron porphyrin complex, iron(III) meso‐tetra(N‐methyl‐4‐pyridyl)porphine chloride [FeIIITMPyP], in 0.1 M triflic acid were investigated by cyclic voltammetry (CV) and spectroelectrochemistry in conjunction with density functional theory (DFT) calculations. The formal potentials of the FeIIITMPyP catalyst and the redox mediators, as well as the half‐wave potentials for the ORR, were determined by CV in the absence and presence of oxygen in acidic solutions. UV/Vis spectroscopic and spectroelectrochemical studies confirmed that only the 2,2′‐azino‐bis(3‐ethylbenzothiazioline‐6‐sulfonic acid)diammonium salt (C18H24N6O6S4) showed effective interactions with FeIIITMPyP during the ORR. DFT calculations suggested strong interaction between FeIIITMPyP and the C18H24N6O6S4 redox mediator. The redox mediator caused lengthening of the dioxygen iron bond, which thus suggested easier dioxygen reduction. Consistent results were observed in electrochemical impedance spectroscopic measurements for which the electron‐transfer kinetics were also evaluated.
Vibrational Spectrum and Gas‐Phase Structure of Disulfur Dinitride (S2N2)
Authors: Perrin Agnes , Flores Antognini Andrea , Zeng Xiaoqing , Beckers Helmut , Willner Helge , Rauhut Guntram 
Published: July 2014

AbstractGas‐phase FTIR spectra of the ν6(B‐type) and the ν4(C‐type) fundamental bands of S2N2(D2h) were recorded with a resolution of ≤0.004 cm−1and the vibrational spectrum of S2N2(D2h) in solid Ar has been revisited. All IR‐active fundamentals and four combination bands were assigned in excellent agreement with calculated values from anharmonic VPT2 and VCI theory based on (explicitly correlated) coupled‐cluster surfaces. Accurate experimental vibrational ground‐ and excited‐state rotational constants of32S214N2are obtained from a rovibrational analysis of the ν6and ν4fundamental bands, and precise zero‐point average rz(Rz(SN)=1.647694(95) Å,αz(NSN)=91.1125(33)°) and semi‐experimental equilibrium structures (Re(SN)=1.64182(33) Å,αe(NSN)=91.0716(93)°) of S2N2have been established. These are compared to the solid‐state structure of S2N2and structural properties of related sulfur nitrogen compounds and to results of ab initio structure calculations.
Discrimination between Olfactory Receptor Agonists and Non‐agonists
Authors: Topin Jérémie , de March Claire A. , Charlier Landry , Ronin Catherine , Antonczak Serge , Golebiowski Jérôme 
Published: July 2014

AbstractA joint approach combining free‐energy calculations and calcium‐imaging assays on the broadly tuned human 1G1 olfactory receptor is reported. The free energy of binding of ten odorants was computed by means of molecular‐dynamics simulations. This state function allows separating the experimentally determined eight agonists from the two non‐agonists. This study constitutes a proof‐of‐principle for the computational deorphanization of olfactory receptors.
Direct Trifluoromethylthiolation of Alcohols under Mild Reaction Conditions: Conversion of ROH into RSCF3
Authors: Nikolaienko Pavlo , Pluta Roman , Rueping Magnus 
Published: July 2014

AbstractA direct process for the trifluoromethylthiolation of allylic and benzylic alcohols under mild conditions has been developed. A wide range of free alcohols underwent nucleophilic substitution in the presence of stable CuSCF3 and BF3⋅Et2O to give the corresponding products in good to excellent yields.
Design of Fluorescent Nanocapsules as Ratiometric Nanothermometers
Authors: Zhegalova Natalia G. , Dergunov Sergey A. , Wang Steven T. , Pinkhassik Eugene , Berezin Mikhail Y. 
Published: July 2014

AbstractWe have developed a novel design of optical nanothermometers that can measure the surrounding temperature in the range of 20–85 °C. The nanothermometers comprise two organic fluorophores encapsulated in a crosslinked polymethacrylate nanoshell. The role of the nanocapsule shell around the fluorophores is to form a well‐defined and stable microenvironment to prevent other factors besides temperature from affecting the dyes’ fluorescence. The two fluorophores feature different temperature‐dependent emission profiles; a fluorophore with relatively insensitive fluorescence (rhodamine 640) serves as a reference whereas a sensitive fluorophore (indocyanine green) serves as a sensor. The sensitivity of the nanothermometers depends on the type of nanocapsule‐forming lipid and is affected by the phase transition temperature. Both the fluorescence intensity and the fluorescence lifetime can be utilized to measure the temperature.
Gold‐Catalyzed Oxa‐Povarov Reactions for the Synthesis of Highly Substituted Dihydrobenzopyrans from Diaryloxymethylarenes and Olefins
Authors: Pagar Vinayak Vishnu , Tseng Chang‐Chin , Liu Rai‐Shung 
Published: July 2014

AbstractOxa‐Povarov reactions involving readily available diaryloxymethylarenes and aryl‐substituted alkenes are reported. Their [4+2] cycloadditions were efficiently catalyzed by IPrAuSbF6 (IPr=1,3‐bis(diisopropylphenyl)imidazol‐2‐ylidene) with high diastereoselectivity. Product analysis revealed that the reactions likely proceed by a stepwise ionic mechanism, because both E‐ and Z‐configured β‐methylstyrene gave the same cycloadducts in the same proportions.
Can Low‐Valent Germanium Chemistry Be Practiced Under Ambient Conditions? A Tale of a Water‐Stable Yet Reactive Germylene Monochloride Complex
Authors: Jha Chandan Kumar , Karwasara Surendar , Nagendran Selvarajan 
Published: July 2014

AbstractA germylene monochloride complex ((DPM)GeCl, 1) that is water stable was isolated for the first time. Interestingly, it reacts with cesium fluoride under ambient conditions (non‐inert atmosphere and water‐containing solvent) to afford water stable germylene monofluoride complex ((DPM)GeF, 2). Due to the usage of DPM (dipyrrinate) ligand, germylene monohalides 1 and 2 show fluorescence in the visible region at 555 and 538 nm, respectively. Compounds 1 and 2 are the first fluorescent germylene complexes and were characterized by multinuclear NMR spectroscopy. The structure of compound 1 was also proved by single crystal X‐ray diffraction studies.
Disupersilylperoxo Radical Anion [tBu3SiOOSitBu3]⋅−: An Intermediate of Supersilanide Oxidation
Authors: Budanow Alexandra , Haeri Haleh Hashemi , Sänger Inge , Schödel Frauke , Bolte Michael , Prisner Thomas , Wagner Matthias , Lerner Hans‐Wolfram 
Published: July 2014

AbstractIn the oxidative process of the supersilanide anion [SitBu3]−, radical species are generated. The continuous wave (cw)‐EPR spectrum of the reaction solution of Na[SitBu3] with O2 revealed a signal, which could be characterized as disupersilylperoxo radical anion [tBu3SiOOSitBu3]⋅− affected by sodium ions though ion‐pair formation. A mechanism is suggested for the oxidative process of supersilanide, which in a further step can be helpful in a better understanding of the oxidation process of isoelectronic phosphanes.
Synthesis and Photophysics of a Red‐Light Absorbing Supramolecular Chromophore System
Authors: Rombouts Jeroen A. , Ravensbergen Janneke , Frese Raoul N. , Kennis John T. M. , Ehlers Andreas W. , Slootweg J. Chris , Ruijter Eelco , Lammertsma Koop , Orru Romano V. A. 
Published: July 2014

AbstractInvited for the cover of this issue is the group of Romano V. A. Orru and Koop Lammertsma at the VU University of Amsterdam. The image depicts the photoexcitation of the aromatic core of a red‐light absorbing supramolecular chromophore system. Read the full text of the article at 10.1002/chem.201402398.
Performance of Surfactant Assisted Synthesis of Fe/TiO2 on the Photodegradation of Diisopropanolamine
Authors: Ramli Raihan Mahirah , Chong Fai Kait , Omar Abdul Aziz , Murugesan Thanapalan 
Published: July 2014

AbstractTitanium dioxide, TiO2 nanoparticles were synthesized via microemulsion method employing Triton X‐100 as the surfactant. Heat treatment was used to remove residual organic entities and also to produce anatase TiO2. Iron (Fe) was incorporated by wet impregnation into the TiO2 nanoparticles in order to shift the active region of the photocatalyst from UV into visible region. The Fe/TiO2 photocatalyst was characterized and their performance on the degradation of aqueous diisopropanolamine solution was compared with the commercial TiO2. The optimum conditions for the photodegradation of aqueous diisopropanolamine were found to be at 0.2 wt% of Fe. The present synthesized Fe/TiO2 photocatalyst showed an improved performance over the commercial TiO2 on the COD removal.
The Age, Growth, Fecundity ofCarassius auratusin the Guohe River of Guoyang County
Authors: Wan An , Yu Shijin , Hu Jin , Wan Yun , Wei Ying , Zhong Ming , Yang Hongfei , An Shuqing , Yan Yunzhi 
Published: July 2014

AbstractTo assess the water quality of the Guohe River, the age, growth, and fecundity ofCarassius auratusin the Guohe River were studied. It was found that the species consists of groups aged one and two with a sex ratio of 30.67:1 (females/males) –C. auratushas the first sexual maturity at the age of one (the year after being hatched). The power function relationship existed between total length (TL) and total or somatic weight (TW, SW). The TL–TW equations for the whole group was TW = 0.0021 TL2.6392(R2 = 0.9301,p < 0.01), and the TL–SW equations for the whole group was SW = 0.0027 TL2.4164(R2 = 0.936,p < 0.01), respectively. The individual absolute fecundity was 28 151 eggs. And the relative fecundity was 148.84 eggs/g fish. A linear relationship existed between the absolute fecundity and the total weight. All results showed that there was a suitable environment for the survival ofC. auratusin the water area. But in an unstable situation the feralC. auratuspopulation revealed an “exploitation” pattern with younger age, more female, and higher fecundity in the Guohe River, which may have mainly been caused by serious paroxysmal pollution accidents.
Increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States
Authors: Chien Franklin L. , Schwartz Stephen M. , Johnson Rebecca H. 
Published: July 2014

BACKGROUNDAlthough rising incidence rates of testicular germ cell tumors have been well documented in white men, relatively little is known about rates in men of Hispanic origin. In the current study, the authors compared germ cell tumor trends between men of Hispanic and non‐Hispanic origin as a function of age at diagnosis.METHODSTrends in testicular germ cell tumor incidence among white men were analyzed according to Hispanic ethnicity in 2 data sets of the National Cancer Institute's Surveillance, Epidemiology, and End Results Program, spanning from 1992 to 2010 and from 2000 to 2010 and sampling 15% and 28% of the United States population, respectively. Rates were age‐adjusted to the year 2000 US standard population.RESULTSBetween 1992 and 2010, the annual incidence of testicular germ cell tumors among Hispanic whites ages 15 to 39 years increased 58%, from 7.18 cases per 100,000 in 1992 to 11.34 cases per 100,000 by 2010 (P<1 × 10−9). Their incidence rates increased in metropolitan areas for both seminoma and nonseminoma subtypes and for all stages at diagnosis. During the same 19‐year interval, incidence among non‐Hispanic white young adults increased 7%, from 12.41 to 13.22 per 100,000. During the 2000 to 2010 interval, no significant trends were observed in incidence among non‐Hispanic whites.CONCLUSIONSThere has been a recent substantial increase in testicular germ cell tumor incidence among Hispanic adolescents and young adults in the United States. Similar trends were not observed in non‐Hispanic whites. Cancer 2014;120:2728–2734. © 2014 American Cancer Society.
Polymorphisms in folate‐metabolizing enzymes and response to 5‐fluorouracil among patients with stage II or III rectal cancer (INT‐0144; SWOG 9304)
Authors: Ulrich Cornelia M. , Rankin Cathryn , Toriola Adetunji T. , Makar Karen W. , Altug‐Teber Özge , Benedetti Jacqueline K. , Holmes Rebecca S. , Smalley Stephen R. , Blanke Charles D. , Lenz Heinz‐Josef 
Published: July 2014

BACKGROUNDRecurrence and toxicity occur commonly among patients with rectal cancer who are treated with 5‐fluorouracil (5‐FU). The authors hypothesized that genetic variation in folate‐metabolizing genes could play a role in interindividual variability. The objective of the current study was to evaluate the associations between genetic variants in folate‐metabolizing genes and clinical outcomes among patients with rectal cancer treated with 5‐FU.METHODSThe authors investigated 8 functionally significant polymorphisms in 6 genes (methylenetetrahydrofolate reductase [MTHFR] [C677T, A1298C], SLC19A1 [G80A], SHMT1 [C1420T], dihydrofolate reductase [DHFR] [Del19bp], TS 1494del,and TSER) involved in folate metabolism in 745 patients with TNM stage II or III rectal cancer enrolled in a phase 3 adjuvant clinical trial of 3 regimens of 5‐FU and radiotherapy (INT‐0144 and SWOG 9304).RESULTSThere were no statistically significant associations noted between polymorphisms in any of the genes and overall survival, disease‐free survival (DFS), and toxicity in the overall analyses. Nevertheless, there was a trend toward worse DFS among patients with the variant allele of MTHFR C677T compared with wild‐type, particularly in treatment arm 2, in which patients with the MTHFR C677T TT genotype had worse overall survival (hazards ratio, 1.76; 95% confidence interval, 1.06‐2.93 [P = .03]) and DFS (hazards ratio, 1.84; 95% confidence interval, 1.12‐3.03 [P = .02]) compared with those with homozygous wild‐type. In addition, there was a trend toward reduced hematological toxicity among patients with variants of SLC19A1 G80A in treatment arm 1 (P for trend, .06) and reduced esophagitis/stomatitis noted among patients with variants of TSER in treatment arm 3 (P for trend, .06).CONCLUSIONSGenetic variability in folate‐metabolizing enzymes was found to be associated only to a limited degree with clinical outcomes among patients with rectal cancer treated with 5‐FU. Cancer 2014;120:3329–3337. © 2014 American Cancer Society.