bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is three-dimensional ultrasonography a valuable diagnostic tool for patients with ovarian cancer? Systematic review and meta-analysis
Authors: Liu Yuan , Zhang Qingdong , Zhang Fang , Liu Meiyan , Zhang Jun , Cao Xiaoli , Yin Weihong 
Published: July 2024

IntroductionThis paper was to assess the diagnostic performance and clinical value of three-dimensional ultrasonography (3DUS), three-dimensional ultrasonography power Doppler (3DPD), and 3DUS combined with 3DPD in ovarian cancer (OC).MethodsThe study was registered with PROSPERO (CRD 42023405765). PubMed and Web of Science were searched from inception to 25 January 2022, and reference lists of potentially eligible studies were also manually searched. Patient and study characteristics were extracted by two independent reviewers. Any discrepancies were addressed through discussion. The sensitivity, specificity, positive and negative likelihood ratio (PLR and NLR, respectively), and the area under the receiver operating characteristic curve (AUC) were pooled separately.ResultsWe retrieved 2,566 studies, of which 18 were finally enrolled, with 2,548 cases. The pooled sensitivity, specificity, PLR, NLR, and AUC for 3DUS were 0.89 (95% CI: 0.85–0.93), 0.93 (95% CI: 0.88–0.96), 13.1 (95% CI: 7.3–23.4), 0.11 (95% CI: 0.08–0.16), and 0.90 (95% CI: 0.87–0.93), respectively. The pooled sensitivity, specificity, PLR, NLR, and AUC for 3DPD were 0.90 (95% CI: 0.80–0.95), 0.85 (95% CI: 0.71–0.92), 5.8 (95% CI: 3.0–11.2), 0.12 (95% CI: 0.06–0.24), and 0.94 (95% CI: 0.91–0.96), respectively. The pooled sensitivity, specificity, PLR, NLR, and AUC for 3DUS combined with 3DPD were 0.99 (95% CI: 0.73–1.00), 0.95 (95% CI: 0.85–0.99), 21.9 (95% CI: 6.1–78.9), 0.01 (95% CI: 0.00–0.37), and 0.99 (95% CI: 0.98–1.00), respectively.Conclusions3DUS, 3DPD, and 3DUS combined with 3DPD are promising diagnostic tools for OC, alongside elevated sensitivity and specificity. However, the combination of 3DUS and 3DPD techniques has higher diagnostic efficiency.Systematic Review Registrationhttps://www.crd.york.ac.uk/PROSPERO/, identifier CRD 42023405765.
Hyperosmolarity in children with hyperammonemia: a risk of brain herniation at the start of renal replacement therapy
Authors: Maghmoul Yousra , Wiedemann Arnaud , Barcat Lucile , Parente Fabienne , Allard Pierre , Alvarez Fernando , Jouvet Philippe 
Published: July 2024

PurposeRenal replacement therapy (RRT) is used in hyperammonemia to reduce the concentration of ammonia in the blood. In the case of plasma hyperosmolarity, RRT can also rapidly decrease plasma osmolarity, which may increase cerebral edema in these patients and favor the occurrence of brain herniation.MethodsWe conducted a retrospective clinical study in a tertiary care university-affiliated hospital. All patients admitted in a Pediatric Intensive Care Unit (PICU), less than 18 years old with ammonemia &gt;150 µmol/L and who underwent RRT between January 2015 and June 2023 were included. We collected data on plasma osmolarity levels, osmolar gap and blood ammonia levels before and during RRT.ResultsEleven patients were included (10 with acute liver failure and 1 with a urea cycle disorders). Their mean age was 36.2 months. Before RRT, the median highest measured osmolarity was 320 (305–324) mOsm/L, whereas the median calculated osmolarity was 303 (293–314) mOsm/L, corresponding to an osmolar gap of 14 mOsm/L. Ammonia blood level over 400 µmol/L are significantly associated with higher plasma osmolarity (P-Value &lt;0.001). In one case, a patient had a brain herniation episode after a quick osmolar drop. This episode was reversed by the administration of hyperosmolar agents and the temporary suspension of RRT.ConclusionThis study highlights the hyperosmolarity and high osmolar gap that occur in children with hyperammonemia. A careful monitoring and control of plasma osmolarity evolution may alert clinician on the risk of occurrence of neurological complication such as brain herniation.
Pharmacovigilance study of GLP-1 receptor agonists for metabolic and nutritional adverse events
Authors: He Long , Li Qiuyu , Yang Yongfeng , Li Jiahao , Luo Wei , Huang Yilan , Zhong Xiaoyan 
Published: July 2024

Aims: Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) are employed extensively in the management of type 2 diabetes and obesity. However, there is a paucity of real-world data on their safety and tolerability for metabolic and nutritional adverse events in large sample populations. This study aimed to analyse the metabolic and nutritional safety signatures of different GLP-1 RAs by exploring the Food and Drug Administration (FDA) Adverse Event Reporting System (FAERS).Methods: AEs data were extracted from the FDA Adverse Event Reporting System database for each GLP-1 RA from the time of its launch until the second quarter of 2023. The reported odds ratio (ROR), proportional reporting ratio (PRR), Empirical Bayesian Geometric Mean and Bayesian Confidence Propagation Neural Network were employed to identify AE signals.Results: A system organ class of metabolism and nutrition disorders was employed to filter AE reports, resulting in the identification of 10,450 reports for exenatide, 2,860 reports for liraglutide, 240 reports for albiglutide, 4,847 reports for dulaglutide, 2,905 reports for semaglutide, 1,089 reports for tirzepatide, and 13 reports for lixisenatide. Semaglutide (ROR, 3.34; 95%CI, 3.22), liraglutide (ROR, 2.78; 95%CI, 2.69), and exenatide (ROR, 2.15; 95%CI, 2.11) were associated with metabolism and nutrition disorders. The number of AE signals detected were as follows: albiglutide (n = 1), lixisenatide (n = 2), tirzepatide (n = 11), exenatide (n = 12), liraglutide (n = 16), semaglutide (n = 20), dulaglutide (n = 22). Dehydration was the most frequent AE contributing to serious outcomes for liraglutide (n = 318, 23.93%), dulaglutide (n = 434, 20.90%), semaglutide (n = 370, 25.10%) and tirzepatide (n = 70, 32.86%). The time to onset (TTO) of AE was statistically different between exenatide and the other GLP-1 RAs (p &lt; 0.001), and the Weibull parameters for dehydration for liraglutide, dulaglutide, and semaglutide analyses all showed an early failure-type profile.Conclusion: Our study suggests that exenatide, liraglutide, and semaglutide are more susceptible to metabolic and nutritional AEs than other GLP-1 RAs. Liraglutide, dulaglutide, semaglutide, and tirzepaptide’s potential to induce dehydration, necessitates special attention. Despite certain deficiencies, GLP-1 RAs have considerable potential for the treatment of eating disorders.
Genome-wide data reveal bi-direction and asymmetrical hybridization origin of a fern species Microlepia matthewii
Authors: Luo Jun-Jie , Shang Hui , Xue Zhi-Qing , Wang Ying , Dai Xi-Ling , Shen Hui , Yan Yue-Hong 
Published: July 2024

IntroductionNatural hybridization is common and plays a crucial role in driving biodiversity in nature. Despite its significance, the understanding of hybridization in ferns remains inadequate. Therefore, it is imperative to study fern hybridization to gain a more comprehensive understanding of fern biodiversity. Our study delves into the role of hybridization in shaping fern species, employing Microlepia matthewii as a case study to investigate its origins of hybridization.MethodsWe performed double digest Genotyping-by-sequencing (dd-GBS) on M. matthewii and its potential parent species, identifying nuclear and chloroplast SNPs. Initially, nuclear SNPs were employed to construct the three cluster analysis: phylogenetic tree, principal component analysis, and population structure analysis. Subsequently, to confirm whether the observed genetic mixture pattern resulted from hybridization, we utilized two methods: ABBA-BABA statistical values in the D-suite program and gene frequency covariance in the Treemix software to detect gene flow. Finally, we employed chloroplast SNPs to construct a phylogenetic tree, tracing the maternal origin.Results and discussionThe analysis of the nuclear SNP cluster revealed that M. matthewii possesses a genetic composition that is a combination of M. hancei and M. calvescens. Furthermore, the analysis provided strong evidence of significant gene flow signatures from the parental species to the hybrid, as indicated by the two gene flow analyses. The samples of M. matthewii cluster separately with M. hancei or M. calvescens on the chloroplast systematic tree. However, the parentage ratio significantly differs from 1:1, suggesting that M. matthewii is a bidirectional and asymmetrical hybrid offspring of M. hancei and M. calvescens.
Development of a marital self-disclosure programme for alleviating the fear of cancer recurrence in patients with gastric cancer and undergoing chemotherapy: a modified Delphi method
Authors: Zhou Ye , Che Chong Chin , Chong Mei Chan , Zhao Haiyan 
Published: July 2024

AimThis study aimed to develop a marital self-disclosure programme to alleviate the fear of cancer recurrence in patients with gastric cancer who are undergoing chemotherapy.DesignDelphi method.MethodsData from available literature and stakeholder interviews were utilised to formulate the initial draft of a marital self-disclosure programme aimed to alleviate the fear of cancer recurring in patients with gastric cancer and undergoing chemotherapy. A panel of experts subsequently conducted a two-round modified Delphi method to finalise the programme.ResultsA total of 13 experts participated in the first round of consultation, while 11 experts were involved in the second round, as two experts withdrew due to unavailability. The response rates of both rounds of expert consultation were 100 and 84.62%, respectively, and the expert authority coefficients (Cr) of the programme were 0.83 and 0.84, respectively. The coordination coefficients of the expert opinions were 0.124 (χ2 = 61.214, p = 0.010) and 0.167 (χ2 = 69.668, p = 0.001) for each Delphi round. The average score of the second round was (4.545 ± 0.688) to (5.000 ± 0), with a full score ratio of 0.55–1.00. The coefficient of variation (CV) ranged from 0 to 0.031. Outcomes from both rounds of consultations were considered acceptable and credible. The finalised marital self-disclosure programme for alleviating the fear of cancer recurrence in patients with gastric cancer undergoing chemotherapy consists of two parts; disclosure guidance for patients and their spouse with nine items, and the structure and themes of marital self-disclosure with 31 items.Patient or public contributionAfter two rounds of expert consultations, the marital self-disclosure programme for patients with gastric cancer undergoing chemotherapy is suggested to be scientifically valid and reliable. This programme is anticipated to potentially support patients and their spouses effectively by providing a reliable intervention plan focused on alleviating the fear of cancer recurrence.
A study on the relationship between yoga exercise intervention and the comprehensive well-being of female college students
Authors: Liu Lanjuan , Liu Dandan , Liu Cheng , Si Yanran 
Published: July 2024

BackgroundDue to the influence of theories, tools, and methodologies in studying well-being, sports science has predominantly focused on subjective well-being, with less attention given to psychological well-being and even less to the integrated study of comprehensive well-being. This study aims to analyze the relationship between yoga exercise intervention and the comprehensive well-being of college students and to explore the mechanism of a yoga exercise intervention to improve the comprehensive well-being of female college students.MethodsWith 92 female college students as subjects, the “Comprehensive Well-being Scale” was used, and research methods such as yoga exercise intervention, questionnaire surveys, qualitative analysis, expert interviews, and statistical analysis were employed to investigate the role of a yoga exercise intervention on the comprehensive well-being of female college students.ResultsAmong the nine dimensions of comprehensive well-being, the three dimensions of subjective well-being and the two dimensions of psychological well-being (health concern and personality growth) of female college students were significantly improved. Additionally, four other dimensions of psychological well-being also showed significant improvement. Furthermore, the improvement in the life satisfaction of female college students’ subjective well-being was mainly achieved through yoga meditation, while partner yoga posture practice could help individuals gradually form a stable pattern of altruistic behavior.ConclusionYoga exercise intervention can improve the comprehensive well-being of female college students and can be an effective counseling method for college students’ mental health education.
Glycolysis Changes in Alloreactive Memory B Cells in Highly Sensitized Kidney Transplant Recipients Undergoing Desensitization Therapy
Authors: Noble Johan , Cabezas Lara , Truffot Aurelie , Dumolard Lucile , Jouve Thomas , Malvezzi Paolo , Rostaing Lionel , Dard Céline , Saas Philippe , Cravedi Paolo , Macek-Jilkova Zuzana 
Published: July 2024

Despite the growing use of desensitization strategies, hyperimmune patients remain at high risk of antibody-mediated rejection suggesting that, even when donor-specific antibodies (DSA) are effectively depleted, anti-donor specific B cells persist. We included 10 highly sensitized recipients that underwent desensitization with plasmapheresis and B cell depletion prior to kidney transplantation. We quantified changes in DSA (luminex), total B-cell subsets (flow cytometry), anti-donor HLA B cells (fluorospot), and single-cell metabolism in serially collected samples before desensitization, at the time of transplant, and at 6 and 12 months thereafter. Desensitization was associated with a decrease in DSA and total memory B cell and naive B cell percentage, while plasma cells and memory anti-donor HLA circulating B cells persisted up to 12 months after transplant. At 12-month post-transplantation, memory B cells increased their glycolytic capacity, while proliferative KI67+ plasma cells modified their metabolism by increasing fatty acid and amino acid oxidation capacity and decreasing their glucose dependence. Despite effective DSA depletion, anti-donor B cells persist in kidney transplant recipients. Due to the reliance of these cells on glycolysis, glycolysis-targeting therapies might represent a valuable treatment strategy.
The Effect of Irrigation on the Vineyard Canopy and Individual Leaf Morphology Evaluated with Proximal Sensing, Colorimetry, and Traditional Morphometry
Authors: Lepej Peter , Taranyi Dóra , Rakun Jurij , Nagy Balázs , Steckl Szabina , Lukácsy György , Mikóczy Nárcisz , Nyitrainé Sárdy Diána Ágnes , Bodor-Pesti Péter 
Published: July 2024

The high number of grapevine (Vitis vinifera L.) cultivars grown world-wide are described and identified according to detailed morphological and morphometric descriptor lists. The grapevine leaf is of utmost importance in characterization, despite its traits being very sensitive to environmental factors. In this study, the effect of irrigation/drought stress on the individual leaf morphology and morphometry of the ‘Hárslevelű’ grapevine (Vitis vinifera L.) cultivar was examined. To verify the effect of the applied irrigation methods (drip and subsoil irrigation) on the plant’s water status, water potential measurements were carried out during the 2022 season. The effect of the applied treatments on the vegetative growth was evaluated according to point quadrat and a multichannel LiDAR analysis in order to describe the width of the canopy area, row volume, and area coverage index. The individual leaf morphology was assessed via traditional morphometry and colorimetry. Our results showed that rainfed plants had a significantly lower stem ψ compared to the drip- and subsoil-irrigated plants at all examined dates. The point quadrat results indicate that the leaf layer number was significantly (p < 0.05) influenced by the position, while the treatment showed no effect on the leaf layer number. The leaf colorimetry showed a difference among the samples, as significant alterations were found in 28 out of the 32 examined color properties. Within the traditional morphometric analysis, 54 traits were evaluated, and 14 of the traits were significantly altered due to the different water management systems.
With Blue Light against Biofilms: Berberine as Natural Photosensitizer for Photodynamic Inactivation of Human Pathogens
Authors: Wimmer Annette , Glueck Michael , Liu Jun , Fefer Michael , Plaetzer Kristjan 
Published: July 2024

Evolving antibiotic resistance of bacteria is a prevailing global challenge in health care and requires the development of safe and efficient alternatives to classic antibiotics. Photodynamic Inactivation (PDI) has proven to be a promising alternative for treatment of a broad range of microorganisms. Photodynamic Inactivation uses photoactive molecules that generate reactive oxygen species (ROS) upon illumination and in the presence of oxygen, which immediately kill pathogenic target organisms. Relevant photoactive properties are provided by berberine. Originally extracted from Barberry (Berberis vulgaris), it is a natural compound widely used in Traditional Chinese Medicine for its antimicrobial and anti-inflammatory effects. With this study, we demonstrated the potential of berberine chloride hydrate (Ber) as a photosensitizer for PDI of important human pathogens, Gram(+) Staphylococcus capitis subsp. capitis, Gram(+) Staphylococcus aureus, and Gram(−) Escherichia coli. In vitro experiments on planktonic and biofilm cultures were conducted focusing on Ber activated with visible light in the blue wavelength range. The number of planktonic S. capitis cells was reduced by 7 log10 steps using 100 µM Ber (5 min incubation, illumination with 435 nm LED array, radiant exposure 25 J/cm2). For an antibacterial effect of 4 log10 steps, static S. capitis biofilms required 1 mM Ber, a drug-to-light interval of 60 min, and illumination with 100 J/cm2. Almost all planktonic cells of Staphylococcus aureus could be photokilled using 100 µM Ber (drug-to-light interval of 30 min, radiant exposure 25 J/cm2). Biofilms of S. aureus could be phototreated (3 log10 steps inactivation) when using 1 mM Ber incubated for 5 min and photoactivated with 100 J/cm2. The study is highlighted by the proof that PDI treatment using Ber showed an antibacterial effect on Gram(−) E. coli. Planktonic cells could be reduced by 3 log10 steps with 100 µM Ber (5 min incubation, 435 nm, 25 J/cm2). With 5 mM ethylenediamine tetraacetic acid disodium salt dihydrate (Na2EDTA) or 1.2% polyaspartic acid (PASA) in addition, a relative inactivation of 4 log10 steps and 7 log10 steps, respectively, was detectable. Furthermore, we showed that an antibacterial effect of 3.4 log10 towards E. coli biofilms was given when using 1 mM Ber (5 min incubation, 435 nm, 100 J/cm2). These results underscore the significance of PDI-treatment with Ber as a natural compound in combination with blue light as valuable antimicrobial application.
Methodology for assessing the potential for commercialization of the university’s scientific and technical elaborations
Authors: Герасимов К.Б. , Зубарев Н.Ю. 
Published: July 2024

В настоящее время большое внимание уделяется инновационной деятельности экономических систем разных уровней, в том числе университетов. При этом актуальной задачей является оценка потенциала коммерциализации научно-технических разработок университетов. В работе представлены различные подходы к проведению оценки потенциала коммерциализации научно-технических разработок университетов. Рассмотрены их этапы во времени, выявлены сильные и слабые стороны и ограничения. В развитие авторского алгоритма оценивания коммерческого потенциала инноваций изложена методика оценки потенциала коммерциализации научно-технических разработок университета. Методика включает в себя три этапа, каждый из которых подробно описан в части применяемых показателей оценки, ответственных участников, подготавливаемых документов и категорий принимаемых управленческих решений на основе реализованных на каждом этапе оценочных процедур. Разработанная методика может быть адаптирована под различные университеты с учетом их специфики и потребностей. Внедрение данной методики позволит выстроить комплекс показателей оценки потенциала коммерциализации научно-технических разработок, интегрированный в процесс управления инновационной деятельностью университета.
Currently, much attention is paid to the innovative activities of economic systems at different levels, including universities. At the same time, an urgent task is to assess the potential for commercialization of scientific and technical developments of universities. The paper presents various approaches to assessing the potential for commercialization of scientific and technical developments of universities. Their stages in time are considered, strengths, weaknesses, and limitations are identified. In development of the author's algorithm for assessing the commercial potential of innovations, a methodology for assessing the potential for commercialization of scientific and technical developments of the university is outlined. The methodology includes three stages, each of which is described in detail in terms of the evaluation indicators used, responsible participants, documents prepared and categories of management decisions made based on the evaluation procedures implemented at each stage. The developed methodology can be adapted to various universities, taking into account their specifics and needs. The introduction of this methodology will make it possible to build a set of indicators for assessing the potential for commercialization of scientific and technical developments, integrated into the process of managing the university’s innovative activities.
Denmark’s policy for the development of carbon capture, utilization and storage
Authors: Армашова-Тельник Г С. , Рыжова А.В. 
Published: July 2024

В статье рассматриваются стратегические документы Дании в сфере развития технологий улавливания, хранения и использования диоксида углерода. Анализируется создание нормативно-правовой базы и инструментов финансирования. Правительство Дании планирует постепенно переходить на рыночные механизмы развития данных технологий. В частности, посредством таких экономических стимулов, как налоги, квоты на выбросы углекислого газа, продажа «зеленых» сертификатов. Однако в ближайшие годы использование данных технологий будет невозможным без активной государственной поддержки.
The article examines Danish strategic documents in the field of development of carbon capture, utilization and storage. The creation of a regulatory framework and financing instruments is analyzed. The Danish government plans to gradually switch to market mechanisms for the development of these technologies. In particular, through such economic incentives as taxes, carbon dioxide emissions quotas, and the sale of “green” certificates. However, in the coming years, the use of these technologies will be impossible without active government support.