bluuebunny/crossref_metadata_2025_split huggingface dataset:
Manipulated microtopography alters plant community development in fragile farm–pastoral transition zone
Authors: Gao Minxuan , Wang Yining , Ren Yongning , Zhan Jinyan , Xie Tian 
Published: August 2024

Abstract
The ecosystems within agro-pastoral transition zones exhibit inherent fragility and heightened susceptibility to climate variability, exacerbated by profound degradation resulting from anthropogenic activities. Subsequent vegetation degradation in these areas precipitates severe soil erosion, presenting formidable challenges for ecological restoration efforts. The utilization of microtopographic structures to mitigate soil erosion and facilitate vegetation recovery stands as a prominent strategy for vegetation restoration within agro-pastoral transition zones. Despite the acknowledgment in current restoration practices that the efficacy of microtopography-based restoration is contingent upon slope, aspect and elevation, there remains a notable absence of precise observed information on this correlation. This study, conducted in the Bashang Grassland, a typical agro-pastoral transition zone in northern China, aims to fill the information gap concerning the correspondence between microtopographic structures and restoration outcomes. Our findings revealed that microtopography has a significant impact on vegetation characteristics, with outcomes varying by location. Shaded slopes displayed higher biomass and density compared with sunny slopes and valleys. While microtopography affected community structure, it did not substantially alter species richness, highlighting the critical role of location and pit construction in successful restoration endeavors. This study provides insights for the selection, design and assessment of microtopography-based restoration in vulnerable ecosystems.
Out-of-this-world spacesuits: Quantifying uncertainty helps keep heroes safe
Authors: Dennis John W , Haman John T , Warner James E 
Published: August 2024

Abstract
NASA and the US Department of Defense acquire some of the world’s most complex systems. Assessing their effectiveness and reliability requires rigorous statistical planning, including uncertainty quantification (UQ). Here, John W. Dennis, John T. Haman, and James E. Warner walk us through the testing of a new spacesuit system
Clinical efficacy and safety of hyaluronic acid gel injection in the glans penis for treatment of premature ejaculation: systematic review and meta-analysis
Authors: Culha Mehmet Gokhan , Baran Caner , Erkoc Mustafa 
Published: August 2024

Abstract

Background
In recent years, there has been growing interest in the use of hyaluronic acid (HA) for the treatment of premature ejaculation (PE). The efficacy of this treatment is quite controversial.

Aim
This study intended to evaluate the efficacy and safety of glans penis augmentation with HA gel for PE.

Methods
This systematic review includes randomized controlled trials (RCTs), primary clinical trials, prospective and retrospective studies, case series, and case reports. Searches in Embase, PubMed, Cochrane, Web of Knowledge, and ClinicalTrials.gov were performed blindly by 2 reviewers.

Outcomes
Intravaginal ejaculation latency time (IELT), questionnaires about PE, glans circumference (millimeters), and adverse events.

Results
Thirteen studies were included in the evaluation: 4 RCTs, 8 prospective observational studies, and 1 restrospective study. The number of patients who received HA gel on the glans penis was 706. According to the results of 2 placebo-controlled RCTs, HA gel treatment significantly improved IELT at the end of the first month (mean difference [MD], 65.44 seconds). In the first month after the HA gel injection procedure, IELT increased vs before the procedure (MD, 176.18 [95% CI, 146.89-205.48]; P &lt; .001, I2 = 83%). When the IELT values ​​were compared at 6 months after HA gel application, IELT improved vs before the procedure (MD, 143.93 [95% CI, 124.78-163.09]; P &lt; .001, I2 = 82). The glans circumference expanded by approximately 1.5 cm after the procedure (MD, 14.82 mm [95% CI, 12.75-16.90]; P &lt; .001, I2 = 65%). When the side effect profile of other studies was examined, side effects were observed in 91 patients after HA gel injection applied to 598 patients (15.22%). Among these side effects, the most common were pain (n = 46, 7.69%), bulla/nodule formation (n = 25, 4.18%), and ecchymosis (n = 20, 3.34%).

Conclusion
While HA shows promise as a therapeutic option for PE, ongoing research is essential to elucidate its clinical utility, mechanisms of action, and comparative efficacy.
The Radio Galaxy Environment Reference Survey (RAGERS): a submillimetre study of the environments of massive radio-quiet galaxies at z = 1–3
Authors: Cornish Thomas M , Wardlow Julie L , Greve Thomas R , Chapman Scott , Chen Chian-Chou , Dannerbauer Helmut , Goto Tomotsugu , Gullberg Bitten , Ho Luis C , Jiang Xue-Jian , Lagos Claudia , Lee Minju , Serjeant Stephen , Shim Hyunjin , Smith Daniel J B , Vijayan Aswin , Wagg Jeff , Zhou Dazhi 
Published: August 2024

ABSTRACT
Measuring the environments of massive galaxies at high redshift is crucial to understanding galaxy evolution and the conditions that gave rise to the distribution of matter we see in the Universe today. While high-z radio galaxies (HzRGs) and quasars tend to reside in protocluster-like systems, the environments of their radio-quiet counterparts are relatively unexplored, particularly in the submillimetre, which traces dust-obscured star formation. In this study, we search for 850 μm-selected submillimetre galaxies (SMGs) in the environments of massive ($M_{\star }$$\gt 10^{11}$${\rm M}_{\odot }$), radio-quiet ($L_{500 {\rm MHz}}$$\lesssim 10^{25}$ WHz$^{-1}$) galaxies at $z \sim 1\!-\!3$ using data from the SCUBA-2 COSMOS (S2COSMOS) survey. By constructing number counts in circular regions of radius 1–6 arcmin and comparing with blank-field measurements, we find no significant overdensities of SMGs around massive radio-quiet galaxies at any of these scales, despite being sensitive down to overdensities of $\delta \sim 0.4$. To probe deeper than the catalogue we also examine the distribution of peaks in the SCUBA-2 signal-to-noise (SNR) map, which reveals only tentative signs of any difference in the SMG densities of the radio-quiet galaxy environments compared to the blank field, and only on smaller scales (1 arcmin radii, corresponding to $\sim 0.5$ Mpc) and higher SNR thresholds. We conclude that massive, radio-quiet galaxies at cosmic noon are typically in environments with $\delta \lesssim 0.4$, which are either consistent with the blank field or contain only weak overdensities spanning sub-Mpc scales. The contrast between our results and studies of HzRGs with similar stellar masses and redshifts implies an intrinsic link between the wide-field environment and the radio luminosity of the active galactic nucleus at high redshift.
Data reconstruction of the dynamical connection function in f(Q) cosmology
Authors: Yang Yuhang , Ren Xin , Wang Bo , Cai Yi-Fu , Saridakis Emmanuel N 
Published: August 2024

ABSTRACT
We employ Hubble data and Gaussian Processes in order to reconstruct the dynamical connection function in $f(Q)$ cosmology beyond the coincident gauge. In particular, there exist three branches of connections that satisfy the torsionless and curvatureless conditions, parametrized by a new dynamical function $\gamma$. We express the redshift dependence of $\gamma$ in terms of the $H(z)$ function and the $f(Q)$ form and parameters, and then we reconstruct it using 55 $H(z)$ observation data. First, we investigate the case where ordinary conservation law holds, and we reconstruct the $f(Q)$ function, which is very well described by a quadratic correction on top of symmetric teleparallel equivalent of general relativity. Proceeding to the general case, we consider two of the most studied $f(Q)$ models of the literature, namely the square-root and the exponential one. In both cases we reconstruct $\gamma (z)$, and we show that according to Akaike Information Criterion and Bayesian Information Criterion information criteria its inclusion is favoured compared to both $\Lambda$cold dark matter paradigm, as well as to the same $f(Q)$ models under the coincident gauge. This feature acts as an indication that $f(Q)$ cosmology should be studied beyond the coincident gauge.
TIRR regulates mRNA export and association with P-bodies in response to DNA damage
Authors: Glossop Michelle S , Chelysheva Irina , Ketley Ruth F , Alagia Adele , Gullerova Monika 
Published: August 2024

Abstract
To ensure the integrity of our genetic code, a coordinated network of signalling and repair proteins, known as the DNA damage response (DDR), detects and repairs DNA insults, the most toxic being double-strand breaks (DSBs). Tudor interacting repair regulator (TIRR) is a key factor in DSB repair, acting through its interaction with p53 binding protein 1 (53BP1). TIRR is also an RNA binding protein, yet its role in RNA regulation during the DDR remains elusive. Here, we show that TIRR selectively binds to a subset of messenger RNAs (mRNAs) in response to DNA damage. Upon DNA damage, TIRR interacts with the nuclear export protein Exportin-1 through a nuclear export signal. Furthermore, TIRR plays a crucial role in the modulation of RNA processing bodies (PBs). TIRR itself and TIRR-bound RNA co-localize with PBs, and TIRR depletion results in nuclear RNA retention and impaired PB formation. We also suggest a potential link between TIRR-regulated RNA export and efficient DDR. This work reveals intricate involvement of TIRR in orchestrating mRNA nuclear export and storage within PBs, emphasizing its significance in the regulation of RNA-mediated DDR.
Clusters of mammalian conserved RNA structures in UTRs associate with RBP binding sites
Authors: Gadekar Veerendra P , Munk Alexander Welford , Miladi Milad , Junge Alexander , Backofen Rolf , Seemann Stefan E , Gorodkin Jan 
Published: August 2024

Abstract
RNA secondary structures play essential roles in the formation of the tertiary structure and function of a transcript. Recent genome-wide studies highlight significant potential for RNA structures in the mammalian genome. However, a major challenge is assigning functional roles to these structured RNAs. In this study, we conduct a guilt-by-association analysis of clusters of computationally predicted conserved RNA structure (CRSs) in human untranslated regions (UTRs) to associate them with gene functions. We filtered a broad pool of ∼500 000 human CRSs for UTR overlap, resulting in 4734 and 24 754 CRSs from the 5′ and 3′ UTR of protein-coding genes, respectively. We separately clustered these CRSs for both sets using RNAscClust, obtaining 793 and 2403 clusters, each containing an average of five CRSs per cluster. We identified overrepresented binding sites for 60 and 43 RNA-binding proteins co-localizing with the clustered CRSs. Furthermore, 104 and 441 clusters from the 5′ and 3′ UTRs, respectively, showed enrichment for various Gene Ontologies, including biological processes such as ‘signal transduction’, ‘nervous system development’, molecular functions like ‘transferase activity’ and the cellular components such as ‘synapse’ among others. Our study shows that significant functional insights can be gained by clustering RNA structures based on their structural characteristics.
A Phase 1/2a Study Evaluating Safety and Immunogenicity of Ad26.RSV.preF in RSV-seronegative Toddlers Aged 12–24 Months
Authors: Langley Joanne M , Nolan Terry M , Rämet Mika , Richmond Peter C , Rosário Filho Nelson , Haazen Wouter , van den Berg Sara P H , Williams Kristi , Bastian Arangassery Rosemary , Omoruyi Edmund , Williams Durkin Joanna , Salisch Nadine , Van Geet Gunter , van Duijnhoven Wilbert , Heijnen Esther , Callendret Benoit 
Published: August 2024

AbstractBackgroundRespiratory syncytial virus (RSV) causes serious illness in children. The Ad26.RSV.preF vaccine candidate was immunogenic with acceptable safety in a phase 1/2a study of RSV-seropositive children. Here, we assessed its safety and immunogenicity in RSV-seronegative children.MethodsIn this randomized, observer-blinded, placebo-controlled, phase 1/2a study (NCT03606512; https://www.clinicaltrials.gov/ct2/show/NCT03606512), RSV-seronegative toddlers aged 12–24 months received Ad26.RSV.preF (2.5 × 1010 viral particles) or placebo on days 1, 29, and 57 (a meningococcal vaccine [Nimenrix] could substitute for day 57 placebo). Primary endpoints were solicited local and systemic adverse events (AEs; 7 days after each vaccination), unsolicited AEs (28 days postvaccination), and serious AEs (first vaccination until study end). Participants were monitored for RSV-respiratory tract infection to assess infection rates and for severe RSV-lower respiratory tract infection as an indication of enhanced disease. RSV-A2 neutralizing, RSV (A and B) preF binding, and RSV postF immunoglobulin G–binding antibodies were evaluated on days 1 (predose), 8, and 85, and after RSV season 1.ResultsThirty-eight participants were enrolled and vaccinated (Ad26.RSV.preF, n = 20; placebo, placebo/Nimenrix, n = 18). Solicited AEs were more common following Ad26.RSV.preF than placebo; most were mild/moderate. No vaccine-related serious AEs were reported. Five of 19 participants receiving Ad26.RSV.preF and 2/18 receiving placebo or placebo/Nimenrix had confirmed RSV-respiratory tract infection or RSV-associated otitis media; none were considered severe. At the final season 1 study visit, most Ad26.RSV.preF recipients had ≥2-fold increases from baseline in RSV-A2 neutralizing, RSV A and B preF binding, and RSV postF antibodies.ConclusionsAd26.RSV.preF was well tolerated and immunogenic in RSV-seronegative toddlers.
Social supports in patients with cancer attending an Irish cancer center: a cross-sectional study
Authors: Goggin Caitriona , Ged Yasser , Bracken-Clarke Dara , Hannan Michelle , Calacsan Flordeliza , Jordan Emmet , Calvert Paula M , O’Connor Miriam , Horgan Anne M 
Published: August 2024

Abstract
A positive association has been demonstrated between social supports, quality of life, and survival outcomes in cancer. This study assessed levels of social supports among patients with cancer in an Irish institution, with an age- and gender-specific stratification. The study highlights relatively low levels of perceived socio-emotional support and social connectedness, but good levels of tangible and informational support in our cohort of patients with cancer. Cancer clinicians should consider social supports as a factor when deciding upon cancer therapies and surveillance programs, and link in available support services for individuals with low levels of social supports where feasible.
Enduring inequalities in British politics: Muslim women in the Labour Party
Authors: Hussain Farah 
Published: August 2024

Abstract
This article combines an understanding of British politics grounded in the Asymmetric Power Model with intersectionality to comprehend Muslim women’s experiences in the Labour Party. This paper shows that an intersectional framework and an analysis of political parties’ relationships with their members are essential to understanding the enduring inequalities of the British political system. Muslim women are under-represented in our political system; they face multiple forms of discrimination (racism and sexism). Some Muslim men have and use their relative power over Muslim women through their use of biraderi-politicking, and Muslim women do not trust the Labour Party to support them.
Processing of hydrocarbon dust in star-forming galaxies revealed with AKARI
Authors: Kondo Tsubasa , Kondo Akino , Murata Katsuhiro L , Kokusho Takuma , Oyabu Shinki , Suzuki Toyoaki , Katayama Risako , Kaneda Hidehiro 
Published: August 2024

Abstract
Hydrocarbon dust is one of the dominant components of interstellar dust, which mainly consists of polycyclic aromatic hydrocarbons and aliphatic hydrocarbons. While hydrocarbon dust is thought to be processed in interstellar radiation fields or shocks, detailed processing mechanisms are not completely understood yet. We investigate the processing of hydrocarbon dust by analyzing the relation between the luminosities emitted by hydrocarbon dust and the total infrared luminosities $(L_{\mathrm{IR}})$ for 138 star-forming galaxies at redshift $z \lt 0.3$. Using near-infrared 2.5–5$\, \mu {\rm m}$ spectra obtained with AKARI, we derived the luminosities of the aromatic hydrocarbon feature at 3.3$\, \mu {\rm m}$ ($L_\mathrm{aromatic}$) and the aliphatic hydrocarbon feature at 3.4–3.6$\, \mu {\rm m}$ ($L_\mathrm{aliphatic}$). We also derived $L_\mathrm{IR}$ and the radiation field strength by modeling the spectral energy distributions of the 138 galaxies with AKARI, WISE, and IRAS photometry data. We find that galaxies with higher $L_\mathrm{IR}$ tend to exhibit lower $L_\mathrm{aliphatic}/L_\mathrm{aromatic}$ ratios. Furthermore, we find that there is an anti-correlation between $L_\mathrm{aliphatic}/L_\mathrm{aromatic}$ ratios and the radiation field strength, and also that the galaxies with low $L_\mathrm{aliphatic}/L_\mathrm{aromatic}$ ratios are dominated by merger galaxies. These results support the suggestion that hydrocarbon dust is processed through photodissociation in strong radiation fields and/or shocks during merging processes of galaxies; the $L_\mathrm{aliphatic}/L_\mathrm{aromatic}$ ratio is likely to decrease in such harsh interstellar conditions since the aliphatic bonds are known to be chemically weaker than the aromatic bonds.
Alpine grassland community productivity and diversity differences influence significantly plant sexual reproduction strategies
Authors: Kang Xiaomei , Liu Yanjun , Wu Xinyang , Jiang Jiachang , Duan Lijie , Zhang Aoran , Qi Wei 
Published: August 2024

Abstract
Whether and how community structure variation affects plant sexual reproduction is crucial for understanding species’ local adaptation and plant community assembly, but remains unrevealed. In Qinghai-Tibetan grassland communities that differed in aboveground biomass (AGB) and species diversity, we found significant influence of AGB on both species’ reproductive biomass allocation (RBA) and flowering and fruiting time, but of species diversity only on species’ reproductive time. In high-AGB or high-diversity communities, smaller and earlier flowering species generally advanced their reproductive phenology and increased their reproductive allocation for maximizing their reproductive success, whereas larger and later flowering species delayed their reproductive phenology and decreased their reproductive allocation for maximizing their vegetative growth and resource competition. This change in reproductive allocation with the variation in community structures was more pronounced in nonclonal as compared to clonal plant species. Thus, we evidence an important influence of community structure on plant sexual reproduction strategies, and the pattern of the influence depends largely on species biological attributes.
Spontaneous symmetry breaking of cooperation between species
Authors: Hauert Christoph , Szabó György 
Published: August 2024

Abstract
In mutualistic associations, two species cooperate by exchanging goods or services with members of another species for their mutual benefit. At the same time, competition for reproduction primarily continues with members of their own species. In intra-species interactions, the prisoner’s dilemma is the leading mathematical metaphor to study the evolution of cooperation. Here we consider inter-species interactions in the spatial prisoner’s dilemma, where members of each species reside on one lattice layer. Cooperators provide benefits to neighbouring members of the other species at a cost to themselves. Hence, interactions occur across layers but competition remains within layers. We show that rich and complex dynamics unfold when varying the cost-to-benefit ratio of cooperation, r. Four distinct dynamical domains emerge that are separated by critical phase transitions, each characterized by diverging fluctuations in the frequency of cooperation: (i) for large r cooperation is too costly and defection dominates; (ii) for lower r cooperators survive at equal frequencies in both species; (iii) lowering r further results in an intriguing, spontaneous symmetry breaking of cooperation between species with increasing asymmetry for decreasing r; (iv) finally, for small r, bursts of mutual defection appear that increase in size with decreasing r and eventually drive the populations into absorbing states. Typically, one species is cooperating and the other defecting and hence establish perfect asymmetry. Intriguingly and despite the symmetrical model set-up, natural selection can nevertheless favour the spontaneous emergence of asymmetric evolutionary outcomes where, on average, one species exploits the other in a dynamical equilibrium.
Advances in gene and cellular therapeutic approaches for Huntington’s disease
Authors: Piao Xuejiao , Li Dan , Liu Hui , Guo Qing , Yu Yang 
Published: August 2024

Abstract
Huntington’s disease (HD) is an inherited neurodegenerative disorder caused by the abnormal expansion of CAG trinucleotide repeats in the Huntingtin gene (HTT) located on chromosome 4. It is transmitted in an autosomal dominant manner and is characterized by motor dysfunction, cognitive decline, and emotional disturbances. To date, there are no curative treatments for HD have been developed; current therapeutic approaches focus on symptom relief and comprehensive care through coordinated pharmacological and nonpharmacological methods to manage the diverse phenotypes of the disease. International clinical guidelines for the treatment of HD are continually being revised in an effort to enhance care within a multidisciplinary framework. Additionally, innovative gene and cell therapy strategies are being actively researched and developed to address the complexities of the disorder and improve treatment outcomes. This review endeavours to elucidate the current and emerging gene and cell therapy strategies for HD, offering a detailed insight into the complexities of the disorder and looking forward to future treatment paradigms. Considering the complexity of the underlying mechanisms driving HD, a synergistic treatment strategy that integrates various factors—such as distinct cell types, epigenetic patterns, genetic components, and methods to improve the cerebral microenvironment—may significantly enhance therapeutic outcomes. In the future, we eagerly anticipate ongoing innovations in interdisciplinary research that will bring profound advancements and refinements in the treatment of HD.
Food insecurity versus public health? Social resilience
Authors: Abdillah Abdillah , Widianingsih Ida , Buchari Rd Ahmad , Nurasa Heru , Ahmadi Zahra 
Published: August 2024

Abstract
The health problems of low-income communities and their relationship to food insecurity are a widespread problem worldwide. Understanding the complex relationship between these two conditions of food insecurity and health outcomes is the focus of this study. In addressing these issues, managing food security and adopting comprehensive strategies that consider the broader public health of the poor and socially vulnerable requires a multi-pronged approach that integrates sustainable food systems, social protection interventions, community engagement, and nutrition-specific interventions. This study is useful for improving our understanding of the relationship between food insecurity and health outcomes, which ultimately contributes to better health and social resilience strategies.