bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is the Mesoarchean Mulgandinnah shear zone, Pilbara Craton, the world's oldest arc-slicing transform fault?
Authors: Aldoud Abdelmottaleb , Kusky Timothy , Wang Lu 
Published: July 2024

Abstract
Arc-slicing transform faults represent an integral component of convergent margin tectonics. They are developed above oblique subduction systems, cutting through and displacing the entire magmatic section of arcs, leading to tectonic repetition of segments of the overriding plate in the ensuing orogenic collage. Extant examples clearly show this process in Sumatra, New Zealand, and the Philippines, while ancient examples are reported from the Paleozoic Altaids and Neoarchean Superior and Yilgarn cratons. Here, we report data that document that the Paleo-Mesoarchean Eastern Pilbara craton, recently interpreted to be a preserved mid-upper crustal level of a magmatic arc, is cut and repeated by a major 3.0–2.93 Ga arc-slicing fault, the Mulgandinnah, which sliced a previously 600 × 100 km segment of a Mesoarchean arc system, laterally moving different segments to their presently juxtaposed 200 × 200 km preserved fragment. This evidence demonstrates lateral plate motions by 3.0 Ga and shows oblique subduction, arc plutonism, arc-slicing, and repetition, reflecting that crustal growth in modern-style convergent margins was in full operation by the Mesoarchean.
Trends in mortality after emergency department presentation for suicidal behaviour in California
Authors: Goldman-Mellor Sidra , Olfson Mark , Schoenbaum Michael 
Published: July 2024

IntroductionEmergency department patients presenting with non-fatal suicidal behaviour face elevated risk of suicide and all-cause mortality, but the extent to which this has changed over time is unknown. This study tracked trends in mortality risks faced by emergency department patients presenting with deliberate self-harm and suicidal ideation in California.MethodsUsing statewide linked emergency department and death data, we estimated 2010–2016 trends in suicide and all-cause mortality among emergency department patients with either deliberate self-harm (n=111 658) or suicidal ideation (n=162 959). We also calculated average annual percent changes in age-adjusted mortality rates and compared these to the general California population.ResultsDeliberate self-harm and suicidal ideation patients’ age-adjusted suicide rates decreased by approximately 5% per year during the study period; however, their all-cause mortality trends were flat. In the general California population, suicide rate trends were flat while all-cause mortality slightly declined.ConclusionsSuicide mortality unexpectedly declined among self-harming and suicidal patients presenting to California emergency departments. Additional research is needed to understand the reasons behind this decline and inform quality improvement efforts for suicide prevention in hospital settings.
Novel insights into paclitaxel’s role on tumor-associated macrophages in enhancing PD-1 blockade in breast cancer treatment
Authors: Choi Yoonjeong , Kim Seong A , Jung Hanul , Kim Eunhae , Kim Yoon Kyoung , Kim Seohyun , Kim Jaehyun , Lee Yeji , Jo Min Kyoung , Woo Jiwan , Cho Yakdol , Lee Dongjoo , Choi Hongyoon , Jeong Cherlhyun , Nam Gi-Hoon , Kwon Minsu , Kim In-San 
Published: July 2024

BackgroundTriple-negative breast cancer (TNBC) poses unique challenges due to its complex nature and the need for more effective treatments. Recent studies showed encouraging outcomes from combining paclitaxel (PTX) with programmed cell death protein-1 (PD-1) blockade in treating TNBC, although the exact mechanisms behind the improved results are unclear.MethodsWe employed an integrated approach, analyzing spatial transcriptomics and single-cell RNA sequencing data from TNBC patients to understand why the combination of PTX and PD-1 blockade showed better response in TNBC patients. We focused on toll-like receptor 4 (TLR4), a receptor of PTX, and its role in modulating the cross-presentation signaling pathways in tumor-associated macrophages (TAMs) within the tumor microenvironment. Leveraging insights obtained from patient-derived data, we conducted in vitro experiments using immunosuppressive bone marrow-derived macrophages (iBMDMs) to validate if PTX could augment the cross-presentation and phagocytosis activities. Subsequently, we extended our study to an in vivo murine model of TNBC to ascertain the effects of PTX on the cross-presentation capabilities of TAMs and its downstream impact on CD8+ T cell-mediated immune responses.ResultsData analysis from TNBC patients revealed that the activation of TLR4 and cross-presentation signaling pathways are crucial for the antitumor efficacy of PTX. In vitro studies showed that PTX treatment enhances the cross-presentation ability of iBMDMs. In vivo experiments demonstrated that PTX activates TLR4-dependent cross-presentation in TAMs, improving CD8+ T cell-mediated antitumor responses. The efficacy of PTX in promoting antitumor immunity was elicited when combined with PD-1 blockade, suggesting a complementary interaction.ConclusionsThis study reveals how PTX boosts the effectiveness of PD-1 inhibitors in treating TNBC. We found that PTX activates TLR4 signaling in TAMs. This activation enhances their ability to present antigens, thereby boosting CD8+ T cell antitumor responses. These findings not only shed light on PTX’s immunomodulatory role in TNBC but also underscore the potential of targeting TAMs’ antigen presentation capabilities in immunotherapy approaches.
Universal smoking machine adaptor for tobacco product testing
Authors: El-Hellani Ahmad , Watson Clifford H , Huang Michelle , Wilson Clark W , Fleshman Clint C , Petitti Ryan , Pancake Mary , Bennett Chad , Keller-Hamilton Brittney L , Jones Jeremy , Tran Hang , Bravo Cardenas Roberto , Mays Darren , Ye Wei , Borthwick Robert P , Schaff Jason , Williamson Raymond L , Wagener Theodore L. , Brinkman Marielle C 
Published: July 2024

SignificanceHistorically, tobacco product emissions testing using smoking machines has largely focused on combustible products, such as cigarettes and cigars. However, the popularity of newer products, such as electronic cigarettes (e-cigarettes), has complicated emissions testing because the products’ mouth-end geometries do not readily seal with existing smoking and vaping machines. The demand for emissions data on popularly used products has led to inefficient and non-standardised solutions, such as laboratories making their geometry-specific custom adaptors and/or employing flexible tubing, for each unique mouth-end geometry tested. A user-friendly, validated, universal smoking machine adaptor (USMA) is needed for testing the variety of tobacco products reflecting consumer use, including e-cigarettes, heated tobacco products, cigarettes, plastic-tipped cigarillos and cigars.MethodsA prototype USMA that is compatible with existing smoking/vaping machines was designed and fabricated. The quality of the seal between the USMA and different tobacco products, including e-cigarettes, cigars and cigarillos, was evaluated by examining the leak rate.ResultsUnlike commercial, product-specific adaptors, the USMA seals well with a wide range of tobacco product mouth-end geometries and masses. This includes e-cigarettes with non-cylindrical mouth ends and cigarillos with cuboid-like plastic tips. USMA leak rates were lower than or equivalent to commercial, product-specific adaptors.ConclusionThis report provides initial evidence that the USMA seals reliably with a variety of tobacco product mouth-end geometries and can be used with existing linear smoking/vaping machines to potentially improve the precision, repeatability and reproducibility of machine smoke yield data. Accurate and reproducible emissions testing is critical for regulating tobacco products.
Probing secular changes in the gravitational constant with white dwarf spectra
Authors: Le T. D. 
Published: July 2024

AbstractExploring variations in fundamental physics constants across cosmological space-time is of substantial importance in both theoretical and experimental physics. A crucial means of investigating such variations involves comparing laboratory measurements with astrophysical observations. In the present study, we employ a combination of laboratory data and observed Lyman transitions of $$H_2$$

H
2

identified in the white dwarf star GD133. Through this examination, we find the temporal variation of the gravitational constant, $${{\dot{G}}}/{G} = (0.016 \pm 0.098) \times 10^{-15}~\text {year}^{-1}$$

G
˙

/
G
=

(
0.016
±
0.098
)

×

10

-
15

year

-
1

with a gravitational potential $$\phi \approx 10^4,$$

ϕ
≈

10
4

,

and an average total redshift of $$H_2,$$

H
2

,

$$z_{abs} =0.0001820(10).$$

z

abs

=
0.0001820

(
10
)

.

This newly determined constraint on the time variation of G serves as an important tool for advancing discussions within unified theories.
Outcomes of Arthroscopic Debridement of the First Carpometacarpal Joint: A Systematic Review
Authors: SHEHOVYCH Andrew , LAWSON Richard , GRAHAM David J. , SIVAKUMAR Brahman S. 
Published: July 2024

Background: Arthroscopic debridement is increasingly being utilised in patients with early-stage first carpometacarpal joint (FCMCJ) arthritis but has limited supportive evidence. This systematic review evaluates the literature, and reports on outcomes and adverse events following this procedure. Methods: An electronic literature search of PubMed, Embase, Medline and Cochrane Central, looking for studies describing outcomes following arthroscopic debridement in FCMCJ arthritis, was performed in November 2022. Studies where bony resection or interposition was performed as adjuncts were excluded. Reported outcomes included visual analogue scores (VAS) for pain; Disabilities of Arm, Shoulder and Hand (DASH) scores; pinch and grip strength; complications and re-operations. Results: Out of a total of 90 studies revealed from the search, only two studies were eligible for inclusion, with a cohort of 34 patients. Following arthroscopic debridement for FCMCJ osteoarthritis, the mean VAS improved by four units, mean DASH by 22 points, grip strength by 4.5 kg and pinch strength by 2 kg at mean follow-up of 18 months. The pooled complication and re-operation rates were 8.8% and 23.5%, respectively. Conclusions: There is a lack of evidence supporting the utility of FCMCJ arthroscopy and debridement in the management of patients with early arthritis. Although the limited evidence suggests that there may be some therapeutic benefit, further large-scale prospective studies need to be performed before making conclusive recommendations. Level of Evidence: Level III (Therapeutic)
Perilunate Fracture–Dislocation: Results at Mean Follow-Up of 7 Years after ORIF
Authors: BENSEDDIK Anisse , CHOLLEY-ROULLEAU Martin , DAP François , ATHLANI Lionel 
Published: July 2024

Background: Perilunate fracture–dislocations are frequently associated with a high risk of developing post-traumatic arthritis. Current studies indicate that during mid-term follow-ups, radiological signs of arthritis do not appear to correspond with functional score. The aim of this study was to assess the occurrence of posttraumatic arthritis and the wrist function after perilunate dislocations (PLD) and fracture dislocations at a mid-term follow-up of 7 years. Methods: We report the clinical and radiological outcomes of 17 wrists treated for PLD or fracture–dislocation by open reduction and internal fixation through a dorsal approach with dorsal ligament repair. Functional outcomes were evaluated using the short version of the Quick Disabilities of the Arm, Shoulder and Hand questionnaire (QuickDASH), the Patient-Rated Wrist Evaluation questionnaire (PRWE) and the Mayo Wrist Score (MWS). Results of radiographs were assessed using the Herzberg Radiological Scoring Chart. Results: The MWS showed five excellent, five good, five fair and two poor results with an average score of 81%. Radiological analysis using the Herzberg classification revealed midcarpal and/or radiocarpal arthritis in 65% of cases, lunate collapse in 59% and an increase in the mean ulnar translocation ratio in 53% of the cases. Complications included one case of lunate osteonecrosis and one case of stage 3 scapholunate advanced collapse that required revision surgery. Conclusions: Although the clinical and functional outcomes are favourable at mid-term follow-up, radiological evaluation shows a progression towards osteoarthritis (OA). Further research is warranted to refine treatment strategies and investigate factors influencing the development of OA. Level of Evidence: Level IV (Therapeutic)
A Systematic Review and Network Meta-Analysis of Randomised Controlled Trials Comparing Treatments for Displaced Radial Head Fractures
Authors: HAINES Samuel , ABDELMALEK Amir , AKEHURST Harold , AMIRFEYZ Rouin 
Published: July 2024

Background: The aim of this study is to compare the surgical and non-operative management of displaced radial head fractures via a network meta-analysis of randomised controlled trials (RCTs). Methods: RCTs comparing management of isolated, displaced radial head fractures in adults were included in our review and statistical analysis. A systematic review of electronic databases (Medline, Embase and Cochrane Library) were screened for comparative RCTs reporting on the management of displaced radial head fractures in August 2021. Two investigators independently reviewed studies for eligibility and an assessment of bias was performed for each study. A Bayesian network meta-analysis of the included RCTs was performed. Results: Five RCTs (326 patients) were included in our meta-analysis. Treatment methods included radial head arthroplasty (RHA), open reduction internal fixation (ORIF) with metal implants (ORIF-M), ORIF with biodegradable implants (ORIF-B) and non-operative management. In our network meta-analysis of ‘good’ or ‘excellent’ patient-reported outcome measures (PROMs), RHA was significantly favourable to ORIF-M (OR: 0.04, CrI: 0.0011, 0.87), ORIF-B (OR: 0.1 CrI: 0.00076, 6.37). Nonoperative treatment was not shown to be significantly worse than RHA (OR: 0.01 CrI: 2.5e–0.5, 3.61). Conclusions: This network meta-analysis shows that in displaced radial head fractures, RHA is associated with significantly superior functional PROMs than ORIF-M based on the evidence available. Nonoperative management has not been shown to be significantly worse. Level of Evidence: Level III (Therapeutic)
Extraskeletal Ewing Sarcoma Disguised as a Vascular Malformation
Authors: GIRI Sanjay Kumar , RAJPOOT Akanksha , SUBA Santanu 
Published: July 2024

Extraskeletal Ewing sarcoma (EES) is a rare entity, accounting for only 3% of lesions encountered in upper extremity. We present two paediatric patients, who were initially diagnosed with a vascular malformation based on clinical assessment and imaging. Final histopathology revealed Ewing sarcoma of soft tissue origin, confirmed by immunohistochemical analysis. Hand surgeons, who are routinely approached for a myriad of hand pathologies, should be wary and consider EES as a differential when treating such lesions. A multidisciplinary approach with an appropriate treatment algorithm can help in a speedy diagnosis, improving the long-term prognosis of the disease. Level of Evidence: Level V (Therapeutic)
Primary Reconstruction Using Fibular Strut Allograft for Distal Humerus Intra-articular Comminuted Open Fracture (AO/OTA13C2, G-A type IIIA): A Case Report
Authors: LEE Bumseok , OH Jin Rok 
Published: July 2024

Distal humerus intra-articular comminuted open fracture is a challenging injury, with nonunion, infection and stiffness considered as major concerns. We report a 58-year-old woman who was admitted to the emergency department from a car accident, sustaining an open wound with severe comminution of distal humerus and complete articular fracture, classified as AO/OTA 13C2 and Gustillo Anderson type IIIA. Debridement and external fixation was done first, followed by open reduction and internal fixation with fibular strut allograft. The patient showed excellent results in radiological and functional outcomes. Level of Evidence: Level V (Therapeutic)
Elemental Mercury Poisoning by Self-Injection – A Report of Two Cases
Authors: CHANDRAN Aswathy , RAJAN T. M. Sheeja , MENEDAL Akshata , RAJASUBRAMANYA Priyavrata 
Published: July 2024

Injection of mercury into the upper limb is a rare method of self-harm. We report two patients with varied clinical presentations – a 19-year-old male student who injected himself with mercury extracted from a sphygmomanometer bulb and reported to our emergency department 24 hours after the event and a 34-year-old industry worker who presented 2 years after injecting himself with elemental mercury. The management of mercury poisoning is described along with a brief review of literature. Mercury is a toxic element and adequate safety precautions must be taken by the surgical team in the management of such patients. Level of Evidence: Level V (Therapeutic)
Uncovering patterns of white matter degeneration in normal aging: Links between morphometry and microstructure
Authors: Robinson Tyler D. , Sun Yutong L. , Chang Paul T.H. , Chen J. Jean 
Published: July 2024

Abstract
While tract-wise differences in volume and microstructure are common targets of investigation in age-related changes in the white matter (WM), there has been relatively little exploration into other attributes of tract morphometry or its relation to microstructure in vivo, and limited understanding on how they jointly inform the understanding of the WM aging trajectory. This study examines 10 WM tracts for tract-wise differences in morphometry (i.e., volume, length, and volume-to-length ratio) and microstructural integrity (i.e., fractional anisotropy, mean diffusivity, axial diffusivity, and radial diffusivity) using diffusion MRI data from the Human Connectome Project in Aging (HCP-A) with the goal of laying the foundation for a more comprehensive model of age-related WM microstructure-morphometry trajectories with a special focus on age-shifted correlations and sex differences. Results indicated that degeneration in microstructure was detectable at younger ages than changes in morphometry, with widely heterogeneous patterns of interrelation and morphometry-microstructural associations in aging both across tracts and between sexes. Multi-parametric signatures of decline suggest differing stages or mechanisms of degeneration across tracts, with female subjects exhibiting a higher proportion of tracts in later stages of decline than males. This work highlights the value of integrating microstructural and morphometric measures of WM health, and encourages the integration of yet more modalities in improving our mechanistic understanding of WM aging.
Successful management of a delayed presentation of traumatic descending thoracic aorta pseudoaneurysm: a literature review based on a case report
Authors: Sadeghian Mohammad , Ebrahimi Pouya , Soltani Parnian , Ghasemi Massoud , Taheri Homa , Mehrpooya Maryam 
Published: July 2024

Abstract
Background
Blunt traumatic aortic injury (BTAI) is the second leading cause of death due to traumas in young patients. The primary presentation might be chest or interscapular pain, difficulty in breathing, and, in severe cases, hypotension. Considering the rapid deterioration of these patients’ clinical conditions, prompt diagnosis and treatment initiation are crucial. In these injuries, the most involved parts of the aorta are the isthmus (distal to the left subclavian artery) and the descending part in the thorax. Therefore, the main diagnostic strategies include transthoracic echocardiography, CT angiography, and endovascular diagnostic approaches.
Case presentation
The patient was a 19-year-old male presenting with the symptoms of chest pain, dyspnea, and extremities excruciating pain after a car turnover. The initial evaluation showed no abnormal cardiovascular finding except bilateral hemothorax, addressed with chest tubes. Twelve hours later, when the patient was under observation for orthopedic surgeries, his chest pain and dyspnea started, and TTE and CTA showed a grade three descending aneurysm of the aorta. The patient was treated immediately with an endovascular procedure of stent implantation. A delayed debranching surgery was also performed, which resulted in desirable outcomes and uneventful follow-up.

Conclusion
Although open thoracic surgery is the main and almost the only option for treating aneurysms of the aorta in hemodynamically unstable patients, the endovascular procedure has shown superior outcomes in selected patients with appropriate anatomy. Debranching surgery, which can be done simultaneously or with delay after the initial procedure, has proven protective against thromboembolic cerebral events.

Clinical key point
Patients with an aneurysm of the aorta should be transported to a medical center with a multidisciplinary team for an urgent evaluation and treatment. The initial resuscitation and diagnosis are challenging, considering the fatal nature of these injuries, and the selection of the treatment is based on the patient's clinical condition and evaluated anatomy in cardiovascular imaging.
Resveratrol-based nano-formulations as an emerging therapeutic strategy for ovarian carcinoma: autophagy stimulation and SIRT-1/Beclin/MMP-9/P53/AKT signaling
Authors: Kadry Mai O. 
Published: July 2024

Abstract
Background
Resveratrol (RVS) is a stilbene derivative polyphenolic compound extensively recognized for its anti-inflammatory, antioxidant and anti-aging properties, along with its enormous promise in carcinoma treatment. Unfortunately, the oral supplementation of RVS possesses physicochemical and pharmacokinetic constraints that hinder its effects, necessitating the development of suitable administration strategies to improve its effectiveness. As a result, the current study evaluates the use of resveratrol nano-formulations in ovarian cancer therapy. Ovarian cancer was induced in rats using (35 mg/kg BW) 20-Methyl cholanthrene (20-MC) followed by resveratrol and resveratrol nano-formulations therapy for one month.

Results
20-MC highlighted a noticeable alleviation in autophagy (ATF) biomarkers SIRT-1 and Beclin, inflammatory and apoptotic biomarkers MMP-9, P53 and AKT in addition to oxidative and nitrosative stress biomarkers TAC and NOX and ovarian cancer tumor biomarker CA-125.

Conclusions
Resveratrol and resveratrol nano-formulations modulated autophagy, inflammatory and oxidative stress biomarkers with the upper effect for resveratrol nano-formulations in competing 20-MC-induced ovarian cancer.