bluuebunny/crossref_metadata_2025_split huggingface dataset:
Current controversies in prenatal diagnosis 2: should a fetal exome be used in the assessment of a dysmorphic or malformed fetus?
Authors: Chitty Lyn S. , Friedman Jan M. , Langlois Sylvie 
Published: November 2015

What's already known about this topic?

Whole‐exome sequencing is a comprehensive genetic test with a diagnostic yield of 25–30% in postnatal cohorts of undiagnosed patients suspected of having a genetic disorder.
Reports on the use of whole‐exome sequencing prenatally are limited to case reports and small series.
What does this study add?

This report summarizes an oral debate presented at the 19th International Conference on Prenatal Diagnosis and Therapy in Washington, DC, USA on 14 July 2015.
The benefits, limitations and challenges of performing fetal exome sequencing to investigate a pregnancy presenting with a dysmorphic or malformed fetus are discussed.
Growth of 1‐eV GaNAsSb‐based photovoltaic cell on silicon substrate at different As/Ga beam equivalent pressure ratios
Authors: Leong Nelvin , Tan Kian Hua , Loke Wan Khai , Wicaksono Satrio , Li Daosheng , Yoon Soon Fatt , Sharma Prithu , Milakovich Tim , Bulsara Mayank , Fitzgerald Gene 
Published: November 2015

AbstractWe report the performance of 1‐eV GaNAsSb‐based photovoltaic samples grown on a Si substrate using molecular beam epitaxy at different As/Ga beam equivalent pressure (BEP) ratios. The light current–voltage curve and spectral response of the samples were measured. The sample grown at an As/Ga BEP ratio of 10 showed the highest energy conversion efficiency with an open circuit voltage (VOC) of 0.529 V and a short circuit current density of 17.0 mA/cm2. This measured VOC is the highest ever reported value in GaNAsSb 1‐eV photovoltaic cell, resulting in the lowest ever reported Eg/q‐VOC of 0.50 eV. The increase in the As/Ga BEP ratio also resulted in an increase in the bandgap‐voltage offset value (Eg/q‐VOC) and a decrease in quantum efficiency up to As/Ga BEP ratio of 18. Copyright © 2015 John Wiley & Sons, Ltd.
Influence of temperature on luminescent coupling and material quality evaluation in inverted lattice‐matched and metamorphic multi‐junction solar cells
Authors: Ochoa M. , Steiner M. A. , García I. , Geisz J. F. , Friedman D. J. , Algora C. 
Published: November 2015

AbstractInverted metamorphic multi‐junction solar cells have reached efficiencies close to 46%. These solar cells contain very high‐quality materials that exhibit strong luminescent coupling between the junctions. The presence of luminescent coupling has a significant impact on the behavior of multi‐junction solar cells affecting the optimal design of these devices. Because of the importance of studying devices under real operating conditions, the temperature dependence of the luminescent coupling is analyzed over a range of 25–120°C. Luminescent coupling analysis results show a reduction of the luminescent coupling current as a function of temperature in two tandem components of an inverted metamorphic triple junction solar cell such as GaInP/GaAs and GaAs/GaInAs solar cells. This reduction is quantified and examined by means of luminescent coupling analysis and modeling, electroluminescence measurements and optical modeling at the device and subcell level. The results of the models are verified and discussed. Copyright © 2015 John Wiley & Sons, Ltd.
PEG–PLGA copolymers bearing carboxylated side chains: Novel hydrogels with enhanced crosslinking via ionic interactions
Authors: Buwalda Sytze J. , Amgoune Abderrahmane , Bourissou Didier 
Published: November 2015

ABSTRACTNovel water‐soluble amphiphilic block copolymers with pendant carboxylic acid groups are synthesized and used for the preparation of ionically crosslinked hydrogels. d,l‐Lactide (DLLA) and l−3‐(2‐benzyloxycarbonyl)ethyl‐1,4‐dioxane‐2,5‐dione (BED) are copolymerized at different ratios via organo‐catalyzed ring‐opening polymerization using a hydroxyl‐terminated poly(ethylene glycol) (PEG–OH) macroinitiator. Dynamic light‐scattering experiments show that, at low concentrations, aqueous solutions of these PEG‐P(BED‐DLLA) copolymers form micelles and aggregates. At higher concentrations, thermo‐sensitive gels are obtained, exhibiting a reversible gel‐to‐sol transition upon a temperature increase. Ionic interactions between the COOH groups and metal ions (Cu2+ or Ca2+) are shown to significantly shift the gel–sol transition to higher temperatures. Thus, the introduction of COOH groups significantly enhances the water solubility of the amphiphilic PEG–polyester copolymer and allows additional crosslinking interactions to form functionalized hydrogels with improved physical properties, making this new class of hydrogels interesting for various applications. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2016, 54, 1222–1227
Temperature dependence of the convex solubility parameters of organic semiconductors
Authors: Howell Jason S. , Boucher David S. 
Published: November 2015

ABSTRACTSolubility parameter methods have also proven very useful in an array of theoretical and practical applications, particularly regarding the mutual solubility of polymers and organic semiconductors in bulk‐heterojunction composites. The temperature dependence of the solubility and miscibility of organic semiconductors offers a promising route for directing the organization of materials and composites toward optimal morphologies. Here, the convex solubility parameter (CSP) approach is used to investigate the temperature dependence of three organic semiconductors: PCBM, P3HT, and PCPDTBT. The CSPs and mutual solubility regions are computed at several temperatures between 25 °C and 140 °C, and the results are compared to those obtained from a traditional spherical‐fitting algorithm. In addition, the impact that constant and varying thermal expansion coefficients have on the computed solubility parameters across this temperature range is investigated. © 2015 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2016, 54, 81–88
Design, development and evaluation of a compact telerobotic catheter navigation system
Authors: Tavallaei Mohammad Ali , Gelman Daniel , Lavdas Michael Konstantine , Skanes Allan C. , Jones Douglas L. , Bax Jeffrey S. , Drangova Maria 
Published: November 2015

AbstractBackgroundRemote catheter navigation systems protect interventionalists from scattered ionizing radiation. However, these systems typically require specialized catheters and extensive operator training.MethodsA new compact and sterilizable telerobotic system is described, which allows remote navigation of conventional tip‐steerable catheters, with three degrees of freedom, using an interface that takes advantage of the interventionalist's existing dexterity skills. The performance of the system is evaluated ex vivo and in vivo for remote catheter navigation and ablation delivery.ResultsThe system has absolute errors of 0.1 ± 0.1 mm and 7 ± 6° over 100 mm of axial motion and 360° of catheter rotation, respectively. In vivo experiments proved the safety of the proposed telerobotic system and demonstrated the feasibility of remote navigation and delivery of ablation.ConclusionThe proposed telerobotic system allows the interventionalist to use conventional steerable catheters; while maintaining a safe distance from the radiation source, he/she can remotely navigate the catheter and deliver ablation lesions. Copyright © 2015 John Wiley & Sons, Ltd.
Tree‐based channel assignment schemes for multi‐channel wireless sensor networks
Authors: Terzi Caglar , Korpeoglu Ibrahim 
Published: November 2015

AbstractMany sensor node platforms used for establishing wireless sensor networks (WSNs) can support multiple radio channels for wireless communication. Therefore, rather than using a single radio channel for whole network, multiple channels can be utilized in a sensor network simultaneously to decrease overall network interference, which may help increase the aggregate network throughput and decrease packet collisions and delays. This method, however, requires appropriate schemes to be used for assigning channels to nodes for multi‐channel communication in the network. Because data generated by sensor nodes are usually delivered to the sink node using routing trees, a tree‐based channel assignment scheme is a natural approach for assigning channels in a WSN. We present two fast tree‐based channel assignment schemes (called bottom up channel assignment and neighbor count‐based channel assignment) for multi‐channel WSNs. We also propose a new interference metric that is used by our algorithms in making decisions. We validated and evaluated our proposed schemes via extensive simulation experiments. Our simulation results show that our algorithms can decrease interference in a network, thereby increasing performance, and that our algorithms are good alternatives for static channel assignment in WSNs. Copyright © 2015 John Wiley & Sons, Ltd.
A Molecular Hexacoordinated Triorganoaluminum Compound with Trifold Si–H···Al Coordination
Authors: Großekappenberg Henning , Lühmann Nicole , Saak Wolfgang , Müller Thomas 
Published: November 2015

AbstractThe synthesis of a hexacoordinate triorganoaluminum compound Al(NapSiH)3 (6) (NapSiH = 8‐dimethylsilylnaphthyl) is reported. Three additional Si–H···Al contacts complete the coordination sphere around the central aluminum atom. Structural and spectroscopic evidence is provided for an activation of the Si–H bond by the aluminum Lewis acid. This activation is however small when compared to other recently described aluminum / silane complexes. These findings are supported by the results of quantum mechanical calculations, which indicate the presence of three Si–H···Al three center intractions in complex 6.
Cation Effect on Formation of Preyssler‐type 30‐Tungsto‐5‐phosphate: Enhanced Yield of Na‐encapsulated Derivative and Direct Synthesis of Ca‐ and Bi‐Encapsulated Derivatives
Authors: Hayashi Akio , Haioka Terufumi , Takahashi Keita , Bassil Bassem S. , Kortz Ulrich , Sano Tsuneji , Sadakane Masahiro 
Published: November 2015

AbstractThe effect of cations in a reaction mixture for the preparation of the Preyssler‐Jeannin‐Pope type 30‐tungsto‐5‐phosphate [P5W30O110Na]14– is investigated. Reaction of phosphate and tungstate with a P/W ratio of ca. 3.9 in an acidic aqueous solution without cations selectively leads to the Dawson‐type 18‐tungsto‐2‐phosphate, [P2W18O62]6–. Amongst all the alkali cations, only Na+ allows formation of the Preyssler‐type polyanion [P5W30O110Na]14–, with an encapsulated Na+ ion, and the product yield can be improved by increasing Na+ amount. The presence of Li+ ions instead results in the Dawson‐type polyanion [P2W18O62]6–, whereas K+, Rb+, and Cs+ selectively result in the Keggin‐type polyanion [PW12O40]3–. An improved synthetic procedure for the Na+‐encapsulated Preyssler‐ion leading to a higher isolated yield is presented. Furthermore, addition of Ca2+ and Bi3+ compounds allows formation of the Ca2+‐ and Bi3+‐encapsulated Preyssler‐type polyanions, [P5W30O110Ca]13– and [P5W30O110Bi]12–, respectively. Furthermore, single‐crystal XRD structure of the Bi3+‐encapsulated Preyssler‐type polyanions, [P5W30O110Bi]12–, is presented for the first time.
Utilization of Percutaneous Needle Biopsy for Breast Diagnosis in a Comprehensive Breast Center: Implications for Development of Quality Indicators
Authors: Holloway Claire M. B. , Al‐Riyees Lolwah , Saskin Refik 
Published: November 2015

AbstractIntroductionPercutaneous needle biopsy (PNB) is the standard of care for diagnosis of breast lesions. Rates of excisional biopsy for breast diagnosis in North America have been reported at approximately 35 %, although significant regional variation exists. A target rate of PNB for diagnosis of breast abnormalities is needed to facilitate quality improvement. We sought to describe the use of PNB in a referral practice, the clinical scenarios prompting PNB or surgical biopsy (SB), and the accuracy and rate of PNB to inform the ultimate development of a benchmark rate of PNB in breast diagnosis.Materials and methodsFemale patients age 18–90 years, referred to Sunnybrook Health Sciences Centre, a large teaching hospital affiliated with the University of Toronto, with a breast lesion prompting tissue diagnosis with SB and/or PNB between 2002 and 2009 were studied. Each biopsied lesion was characterized by method of biopsy: PNB, SB, or PNB followed by SB. For each lesion, we collected data on patient demographics and breast cancer risk, reason for referral, imaging characteristics (breast imaging‐reporting and data system classification, full description, final impression before biopsy), and pathology from each biopsy method. We report concordance between the final impression pre‐biopsy and the PNB diagnosis with final surgical diagnosis where applicable.ResultsOne thousand and twenty‐six lesions were biopsied, 987 (96 %) with PNB. The benign:malignant ratio for the entire cohort was 1.2:1. Final impression was concordant with final pathology in 674/862 (78 %) and PNB diagnosis was concordant with SB pathology in 487/556 (88 %). The reasons for SB without PNB were required pathologic evaluation of the entire lesion (n = 19), patient choice (n = 5), other biopsy technique used (n = 6), technical (n = 4), planned mastectomy (n = 3), and enlarging mass (n = 2). 155/559 (28 %) of lesions without evidence of malignancy on PNB ultimately underwent SB. Papillary lesions and radial scars were more likely to undergo SB with or without prior PNB. Lesions deemed to be suspicious or malignant on final impression were more likely to be excised after a benign diagnosis at PNB.ConclusionThe vast majority of lesions requiring tissue diagnosis can be accurately diagnosed with PNB. Benchmarks for rates of PNB of 90 % or greater may be considered for performance measurement in appropriate populations.
Autonomic and cardio‐respiratory responses to exercise in Brugada Syndrome patients
Authors: Chanavirut Raoyrin , Makarawate Pattarapong , Macdonald Ian A. , Leelayuwat Naruemon 
Published: November 2015

AbstractBackgroundImbalances of the autonomic nervous (ANS), the cardiovascular system, and ionics might contribute to the manifestation of The Brugada Syndrome (BrS). Thus, this study has aimed to investigate the cardio‐respiratory fitness and the responses of the ANS both at rest and during a sub‐maximal exercise stress test, in BrS patients and in gender‐matched and age‐matched healthy sedentary controls.MethodsEleven BrS patients and 23 healthy controls were recruited in Khon Kaen, Thailand. They performed an exercise test on a cycle ergometer, and during the exercise, expired gas samples and electrocardiograms were collected. Blood glucose and electrolyte concentrations were analyzed before and after exercise. Then the heart rate variability (HRV) and the heart rate recovery (HRR) were analyzed from the electrocardiograms.ResultsThe BrS patients showed a higher parasympathetic activation during exercise recovery than baseline. They had a smaller level of sympathetic activation during the period of exercise recovery than the controls did. They also showed a significantly lower peak HR, HRR, and peak oxygen consumption than the controls (p<0.05). All subjects had a significantly lower percentage of peak oxygen consumption and respiratory exchange ratio during low‐intensity (p<0.01) and moderate‐intensity (p<0.05) exercise than during high‐intensity exercise. The BrS patients had mild hyperkalemia which is reduced according to the exercise.ConclusionThai BrS patients had a more rapid rate of restoration of the parasympathetic and smaller level of sympathetic activation after exercise. They had mild hyperkalemia which is reduced according to the exercise. Furthermore, they exhibited impaired cardio‐respiratory fitness.
Perception vs Reality: Methicillin-Resistant Staphylococcus aureus Carriage Among Healthcare Workers at a Veterans Affairs Medical Center
Authors: Colburn Nora E. , Cadnum Jennifer , Flannery Elizabeth , Chang Shelley , Donskey Curtis J. , Stiefel Usha 
Published: November 2015

In a prevalence study of 209 healthcare workers, 18 (8.6%) and 13 (6.2%) carried methicillin-resistant Staphylococcus aureus in their nares or on their hands, respectively. However, 100 (62%) of 162 workers completing an associated survey believed themselves to be colonized, revealing a knowledge deficit about methicillin-resistant Staphylococcus aureus epidemiology.Infect. Control Hosp. Epidemiol. 2015;37(1):110–112
Impact of Hospital Operating Margin on Central Line–Associated Bloodstream Infections Following Medicare’s Hospital-Acquired Conditions Payment Policy
Authors: Calderwood Michael S. , Vaz Louise E. , Tse Kawai Alison , Jin Robert , Rett Melisa D. , Grant Patricia S. , Lee Grace M. 
Published: November 2015

AbstractIn October 2008, Medicare ceased additional payment for hospital-acquired conditions not present on admission. We evaluated the policy’s differential impact in hospitals with high vs low operating margins. Medicare’s payment policy may have had an impact on reducing central line–associated bloodstream infections in hospitals with low operating margins.Infect. Control Hosp. Epidemiol. 2015;37(1):100–103
Normal cortisol response to cold pressor test, but lower free thyroxine, after recovery from undernutrition
Authors: Martins Vinicius J. B. , Neves Andrea P. O. , Garcia Márcia C. , Spadari Regina C. , Clemente Ana Paula G. , de Albuquerque Maria P. , Hoffman Daniel J. , Sawaya Ana L. 
Published: November 2015

AbstractUndernutrition is a stressor with long-term consequences, and the effect of nutritional recovery on cortisol and thyroid hormone status is unknown. To investigate basal thyroid hormones and the cortisol response to a cold pressor test in children recovered from undernutrition, a cross-sectional study was undertaken on children (6–16 years) separated into four groups: control (n 41), stunted (n 31), underweight (n 27) and recovered (n 31). Salivary cortisol was collected over the course of 10 h: upon awakening, before and after an unpleasant and a pleasant stimulus. Cortisol upon awakening was highest in the stunted and lowest in the underweight groups: control=5·05 (95 % CI 3·71, 6·89) nmol/l, stunted=6·62 (95 % CI 3·97, 11·02) nmol/l, underweight=2·51 (95 % CI 1·75, 3·63) nmol/l and recovered=3·46 (95 % CI 2·46, 4·90) nmol/l (P=0·005). Girls had higher cortisol concentrations upon awakening compared with boys (P=0·021). The undernourished groups showed an elevated cortisol response both to the unpleasant stimulus and at the last measurement (16.00 hours) compared with that of the recovered group: AUC, control=2·07 (95 % CI 1·69, 2·45) nmol/l×30 min, stunted=2·48 (95 % CI 1·91, 3·06) nmol/l×30 min, underweight=2·52 (95 % CI 2·07, 2·97) nmol/l×30 min, recovered=1·68 (95 % CI 1·26, 2·11) nmol/l×30 min (P=0·042); and control=2·03 (95 % CI 1·75, 2·39) nmol/l×30 min, stunted=2·51 (95 % CI 1·97, 3·19) nmol/l×30 min, underweight=2·61 (95 % CI 2·16, 3·16) nmol/l×30 min, recovered=1·70 (95 % CI 1·42, 2·03) nmol/l×30 min (P=0·009). Lower free thyroxine (T4) was found in the recovered and stunted groups: control=1·28 (95 % CI 1·18, 1·39) pmol/l, stunted=0·98 (95 % CI 0·87, 1·10) pmol/l, underweight=1·10 (95 % CI 1·01, 1·21) pmol/l and recovered=0·90 (95 % CI 0·83, 0·99) pmol/l (P<0·001). Multivariate analysis showed a lower cortisol concentration along 10 h (06.00–16.00 hours) in the recovered compared with the other groups (P=0·017), and similar concentrations between the recovered and control group. In conclusion, the children with recovery in weight and height had a cortisol stress response similar to control but a lower basal free T4. Longitudinal studies are warranted to determine the extent of these endocrine changes after recovery of undernutrition and in adulthood.
A novel method for slip prediction of walking biped robots
Authors: Hashlamon Iyad , Gülhan Mehmet Mert , Ayit Orhan , Erbatur Kemalettin 
Published: November 2015

SUMMARYThis paper proposes a new approach for slip prediction of walking biped robots. The slip prediction is a measurement-based and friction behavior-inspired approach. A measurement-based online algorithm is designed to estimate the Coulomb friction which is regarded as a slip threshold. To predict the slip, a safety margin is introduced in the negative vicinity of the estimated Coulomb friction. The estimation algorithm concludes that if the applied force is outside the safety margin, then the foot tends to slip. The proposed approach depends on the available type of measurements. Three options of measurements are discussed. Among them, the foot acceleration and ankle force measurements scenario is validated by experiments on the humanoid SURALP (Sabanci University Robotics Research Laboratory Platform). The results demonstrate the effectiveness of the proposed approach for slip prediction and detection.
Development, design and validation of an assistive device for hand disabilities based on an innovative mechanism
Authors: Conti Roberto , Allotta Benedetto , Meli Enrico , Ridolfi Alessandro 
Published: November 2015

SUMMARYIn accordance with strict requirements of portability, cheapness, and modularity, an innovative assistive device for hand disabilities has been developed and validated. This robotic orthosis is designed to be a low-cost, portable hand exoskeleton to assist people with physical disabilities in their everyday lives. Referring to hand opening disabilities, the authors have developed a methodology which, by starting from the geometrical characteristics of the patient's hand, defines the novel kinematic mechanism that better fits to the finger trajectories. The authors have validated the proposed novel mechanism by carrying out a Hand Exoskeleton System (HES) prototype, based on a single-phalanx mechanism, cable driven. The testing phase of the real prototype with a patient is currently on going.
Preventive Home Visits for Older People: A Systematic Review
Authors: Tourigny André , Bédard Annick , Laurin Danielle , Kröger Edeltraut , Durand Pierre , Bonin Lucie , Sévigny Andrée , Frappier Annie , Roussel Marie Ève , Martin Mélanie 
Published: November 2015

RÉSUMÉL’augmentation du nombre de personnes âgées présentant des incapacités et ayant des maladies chroniques entraîne une hausse des besoins en services de santé à domicile. Le nombre d’études et de revues systématiques traitant des approches préventives pour cette clientèle a proliféré, générant un besoin de synthèse des connaissances. Nous avons mené une revue systématique de revues systématiques évaluant l’effet des programmes de visite préventive pour les personnes âgées. Des 5 973 citations identifiées dans plus de 30 bases de données de littérature grise et scientifique, 10 articles répondaient à tous les critères d’inclusion. Les revues systématiques étaient retenues si elles comprenaient des essais randomisés contrôlés comparant des interventions de soins à domicile offerts par un professionnel de la santé et ceux sans professionnels. Les interventions sont souvent des évaluations gériatriques globales et s’accompagnent de visites de suivi. Il ressort que les visites préventives multidimensionnelles à domicile ont le potentiel de diminuer la mortalité, en particulier chez les personnes âgées plus jeunes, et offrent aussi un potentiel d’amélioration de l’autonomie fonctionnelle. Toutefois, ces résultats doivent être interprétés avec prudence vue la diversité des interventions analysées.