bluuebunny/crossref_metadata_2025_split huggingface dataset:
Emergency robotic surgery: the experience of a single center and review of the literature
Authors: Ceccarelli Graziano , Catena Fausto , Avella Pasquale , Tian Brian WCA , Rondelli Fabio , Guerra Germano , De Rosa Michele , Rocca Aldo 
Published: August 2024

Abstract
Backgrounds
Laparoscopic surgery is widely used in abdominal emergency surgery (AES), and the possibility of extending this approach to the more recent robotic surgery (RS) arouses great interest. The slow diffusion of robotic technology mainly due to high costs and the longer RS operative time when compared to laparoscopy may represent disincentives, especially in AES. This study aims to report our experience in the use of RS in AES assessing its safety and feasibility, with particular focus on intra- and post-operative complications, conversion rate, and surgical learning curve. Our data were also compared to other experiences though an extensive literature review.

Methods
We retrospectively analysed a single surgeon series of the last 10 years. From January 2014 to December 2023, 36 patients underwent urgent or emergency RS. The robotic devices used were Da Vinci Si (15 cases) and Xi (21 cases).

Results
36 (4.3%) out of 834 robotic procedures were included in our analysis: 20 (56.56%) females. The mean age was 63 years and 30% of patients were ≥ 70 years. 2 (5.55%) procedures were performed at night. No conversions to open were reported in this series. According to the Clavien-Dindo classification, 2 (5.5%) major complications were collected. Intraoperative and 30-day mortality were 0%.

Conclusions
Our study demonstrates that RS may be a useful and reliable approach also to AES and intraoperative laparoscopic complications when performed in selected hemodynamically stable patients in very well-trained robotic centers. The technology may increase the minimally invasive use and conversion rate in emergent settings in a completely robotic or hybrid approach.
Granulosa cell insight: unraveling the potential of menstrual blood-derived stem cells and their exosomes on mitochondrial mechanisms in polycystic ovary syndrome (PCOS)
Authors: Mansoori Mahna , Solhjoo Somayeh , Palmerini Maria Grazia , Nematollahi-Mahani Seyed Noureddin , Ezzatabadipour Massood 
Published: August 2024

Abstract
Background
Polycystic ovary syndrome (PCOS) presents a significant challenge in women’s reproductive health, characterized by disrupted folliculogenesis and ovulatory dysfunction. Central to PCOS pathogenesis are granulosa cells, whose dysfunction contributes to aberrant steroid hormone production and oxidative stress. Mitochondrial dysfunction emerges as a key player, influencing cellular energetics, oxidative stress, and steroidogenesis. This study investigates the therapeutic potential of menstrual blood-derived stem cells (MenSCs) and their exosomes in mitigating mitochondrial dysfunction and oxidative stress in PCOS granulosa cells.

Methods
Using a rat model of PCOS induced by letrozole, granulosa cells were harvested and cultured. MenSCs and their exosomes were employed to assess their effects on mitochondrial biogenesis, oxidative stress, and estrogen production in PCOS granulosa cells.

Results
Results showed diminished mitochondrial biogenesis and increased oxidative stress in PCOS granulosa cells, alongside reduced estrogen production. Treatment with MenSCs and their exosomes demonstrated significant improvements in mitochondrial biogenesis, oxidative stress levels, and estrogen production in PCOS granulosa cells. Further analysis showed MenSCs' superior efficacy over exosomes, attributed to their sustained secretion of bioactive factors. Mechanistically, MenSCs and exosomes activated pathways related to mitochondrial biogenesis and antioxidative defense, highlighting their therapeutic potential for PCOS.

Conclusions
This study offers insights into granulosa cells mitochondria’s role in PCOS pathogenesis and proposes MenSCs and exosomes as a potential strategy for mitigating mitochondrial dysfunction and oxidative stress in PCOS. Further research is needed to understand underlying mechanisms and validate clinical efficacy, presenting promising avenues for addressing PCOS complexity.
Salmonid Rickettsial Septicemia (SRS) disease dynamics and Atlantic salmon immune response to Piscirickettsia salmonis LF-89 and EM-90 co-infection
Authors: Carril Gabriela , Morales-Lange Byron , Løvoll Marie , Inami Makoto , Winther-Larsen Hanne C. , Øverland Margareth , Sørum Henning 
Published: August 2024

AbstractIn Chile, Piscirickettsia salmonis contains two genetically isolated genogroups, LF-89 and EM-90. However, the impact of a potential co-infection with these two variants on Salmonid Rickettsial Septicemia (SRS) in Atlantic salmon (Salmo salar) remains largely unexplored. In our study, we evaluated the effect of P. salmonis LF-89-like and EM-90-like co-infection on post-smolt Atlantic salmon after an intraperitoneal challenge to compare changes in disease dynamics and host immune response. Co-infected fish had a significantly lower survival rate (24.1%) at 21 days post-challenge (dpc), compared with EM-90-like single-infected fish (40.3%). In contrast, all the LF-89-like single-infected fish survived. In addition, co-infected fish presented a higher presence of clinical lesions than any of the single-infected fish. The gene expression of salmon immune-related biomarkers evaluated in the head kidney, spleen, and liver showed that the EM-90-like isolate and the co-infection induced the up-regulation of cytokines (e.g., il-1β, ifnγ, il8, il10), antimicrobial peptides (hepdicin) and pattern recognition receptors (PRRs), such as TLR5s. Furthermore, in serum samples from EM-90-like and co-infected fish, an increase in the total IgM level was observed. Interestingly, specific IgM against P. salmonis showed greater detection of EM-90-like antigens in LF-89-like infected fish serum (cross-reaction). These data provide evidence that P. salmonis LF-89-like and EM-90-like interactions can modulate SRS disease dynamics in Atlantic salmon, causing a synergistic effect that increases the severity of the disease and the mortality rate of the fish. Overall, this study contributes to achieving a better understanding of P. salmonis population dynamics.
A study on the photoisomerization of phenylpropanoids and the differences in their radical scavenging activity using in-situ NMR spectroscopy and on-line radical scavenging activity analysis
Authors: Park Sangah , Kim Hojin , Bang Miyeon , Um Byung-Hun , Cha Jin Wook 
Published: August 2024

AbstractPhenylpropanoids are naturally occurring secondary metabolites that exhibit various biological activities such as ultra-violet (UV) light protection and reactive-oxygen species (ROS) scavenging. In this study, we utilized a light-emitting diode (LED) based in-situ UV irradiation nuclear magnetic resonance (NMR) technique to monitor the photoisomerization reactions of these phenylpropanoids under UV irradiation in real-time. Through this approach, we measured the photochemical reaction rates and photostationary state (PSS) ratios of these molecules and observed distinct reaction rate and PSS ratio information depending on the variation of substituent groups in each phenylpropanoid molecule. We also evaluated the radical scavenging activity (RSA) for each photochemical product through diphenyl-1-picrylhydrazyl radical (DPPH) assay and 2,2’-azino-bis(3-ethylbenzenthiazoline-6-sulphonic acid) (ABTS) assay. We found that the photoisomerization product of caffeic acid can increase both DPPH and ABTS radical scavenging activities, and confirmed the enhanced ABTS radical scavenging ability of caffeic acid cis-isomer based on the online high-pressure liquid chromatography (HPLC)-ABTS analysis and the PSS ratio information of each isomer.
The levels of serum lipoprotein(a) on clinical outcomes in Chinese hospitalized patients with cardiovascular diseases
Authors: Min Tingting , Yue Yilin , Fan Xin , Yang Deguang , Su Shaohui , Wan Huaibin 
Published: August 2024

Abstract
Objective
Serum lipoprotein(a) [Lp(a)] is a risk factor of cardiovascular diseases. However, the relationship between the serum Lp(a) and clinical outcomes has been seldom studied in Chinese hospitalized patients with cardiovascular diseases.

Methods
We retrospectively collected the clinical data of hospitalized patients with cardiovascular diseases in the Cardiovascular Department of Dongguan People’s Hospital from 2016 to 2021 through the electronic case system. Patients were divided into 4 groups based on Lp(a) quartiles: Quartile1 (≤ 80.00 mg/L), Quartile 2 (80.01 ~ 160.90 mg/L), Quartile 3 (160.91 ~ 336.41 mg/L), Quartile 4 (> 336.41 mg/L). Cox proportional hazard regression models were constructed to examine the relationship between Lp(a) and cardiovascular events.

Results
A total of 8382 patients were included in this study. After an average follow-up of 619 (320 to 1061) days, 1361 (16.2%) patients developed major adverse cardiovascular events, and 125 (1.5%) all-cause death were collected. The incidence of MACEs was 7.65, 8.24, 9.73 and 10.75 per 100 person-years in each Lp(a) quartile, respectively; the all-cause mortality was 0.48, 0.69, 0.64 and 1.18 per 100 person-years in each Lp(a) quartile, respectively. The multivariate Cox regression analysis suggested that high Lp(a) level was an independent risk factor for MACEs (HR: 1.189, [95% CI: 1.045 to 1.353], P = 0.030) and all-cause death (HR: 1.573, [95% CI: 1.009 to 2.452], P = 0.046).

Conclusion
In addition to traditional lipid indicators, higher Lp(a) exhibited higher risks of adverse cardiovascular events and death, indicated worse prognosis. Lp(a) may be a new target for the prevention of atherosclerotic diseases.
Informed consent form for platelet rich plasma injections: evidence-based and legally guide for orthopaedic surgeons
Authors: Jeyaraman Madhan , Pai Satvik N. , Filippo Migliorini , Jeyaraman Naveen , Venkatasalam Ravichandran , Nallakumarasamy Arulkumar , Khanna Manish , Patro Bishnu Prasad , Sharma Shilpa , Rangarajan Ravi Velamor 
Published: August 2024

AbstractRegarding medico-legal malpractice suits, lawyers and insurers focus on informed consent documentation. Unfortunately, there is no standard protocol for obtaining informed consent for platelet-rich plasma (PRP) injections. The objective of the present study was to create a pre-designed, evidence-based informed consent form specifically for PRP injections. The current evidence on the medico-legal implications of PRP injections was accessed, as well as informed consent in general and specifically informed consent in PRP injections. Additionally, we interviewed orthopaedic surgeons and patients who had undergone PRP injections in the past year using a semi-structured approach. A legally valid and evidence-based informed consent form for PRP injections ensures rights, encouraging open communication and transparency between the patient and surgeon. Moreover, if a lawsuit arose, informed consent would be a critical document in surgeons' defence and would withstand scrutiny from lawyers and the judiciary. An evidence-based informed consent form for PRP injections was elaborated and reviewed by a legal expert to ensure adherence to legal proprieties. The final form of the informed consent for PRP injection was administered for one year and validated at our institution.
Structural dynamics and sustainability in the agricultural sector: the case of the European Union
Authors: Peng Bo , Melnikiene Rasa , Balezentis Tomas , Agnusdei Giulio Paolo 
Published: August 2024

AbstractThis paper seeks to draw a research agenda for unveiling the underlying bottlenecks and possibilities for improving the agricultural total factor productivity in the European Union (EU). To this aim, the paper first surveys the key challenges for the modern agricultural economy. Then, the case of the EU is discussed by looking at the convergence in the partial productivity indicators (including the GHG emission) and growth efficiency that relate to the gap in the total factor productivity growth. The results suggest that the EU member states exhibited growth inefficiency (i.e., a gap in the total factor productivity growth) of 5–9% on average during 2004–2021. The paper also discusses the possibilities to utilize the production theory for assessing the pathways towards improvements in the productivity and sustainability of the EU agriculture.
Knowledge and attitude of university nursing students towards forensic nursing and their influencing factors: a mixed-methods study
Authors: Abou Hashish Ebtsam Aly 
Published: August 2024

Abstract
Background
Forensic nursing, which merges healthcare and legal expertise to address trauma and violence, is vital yet often underrepresented in nursing education. Many nursing students lack knowledge in this field, underscoring the need for enhanced education to improve patient care and legal outcomes. This study aimed to assess university nursing students’ knowledge and attitudes towards forensic nursing, as well as identify factors influencing their knowledge. A mixed-methods design was conducted at a Saudi nursing college with a convenience sample of 250 students. The data were collected using a structured questionnaire comprising two parts. The quantitative part included demographic and academic characteristics, knowledge and opinions on forensic nursing, knowledge of forensic evidence, and attitudes towards forensic nursing. The qualitative part consisted of four open-ended questions about factors affecting forensic knowledge. Data analysis involved inferential statistics and content analysis.

Results
The study revealed that 80.4% of nursing students lacked prior knowledge of forensic nursing, and only 59.76% had some awareness of forensic evidence. A strong positive relationship was found between attitudes towards forensic nursing and knowledge of forensic evidence (r = 0.817, p < 0.001), indicating that positive attitudes could predict 66.8% of the variance in forensic evidence knowledge. Key barriers included lack of support from upper management, insufficient resources, and concerns about faculty qualifications. Students recommended integrating forensic nursing into the curriculum, offering specialized programs, and promoting research and social media awareness campaigns.

Conclusions
These findings underscore significant gaps in knowledge and misconceptions about forensic nursing among participants, emphasizing the critical need for education and awareness in this field. The study highlights the potential implications for integrating forensic nursing concepts into undergraduate curricula, enhancing faculty training, and utilizing diverse teaching modalities. Addressing these gaps will not only improve future nurses’ competency in forensic nursing, but also contribute to better patient care.
Financial inclusion and Financial Performance: The interplay role of capital adequacy requirements in Egyptian Banks
Authors: Obiedallah Yousra R. , Abdelaziz Asmaa H. 
Published: August 2024

Abstract
Purpose
Financial inclusion aims to provide affordable financial services, including banking, loans, equity, and insurance products, to underserved populations. This study aims to examine the moderating effect of a bank’s capital adequacy ratio (CAR) on the nexus between financial inclusion (FI) and a bank’s financial performance (FP) in the Egyptian setting.

Design/methodology/approach
The study uses two empirical linear mixed models (LMM) to test the moderation effect of a bank’s CAR on the association between FI and FP. The study sample comprises 360 bank quarter-observations of 10 listed banks in the Egyptian Stock Exchange (EGX) from 2013 to 2021.

Findings
The findings show that the bank’s CAR strengthens the association between FI dimensions, namely, deposit growth, loan growth, and the number of employees, and the bank’s FP with contradicted directions.

Research limitations/implications
This study provides policymakers insights into the crucial role of complying with banking regulation, namely, the capital adequacy ratio (CAR) and expanding financial inclusion practices to enhance and improve the bank’s FP. Thus, encouraging more strategies and facilities toward financial inclusion.

Originality/value
Due to the scarcity of financial inclusion literature in emerging economies, this paper extends FI literature by highlighting the moderation impact of a bank’s CAR on the relationship between FI dimensions and FP in the Egyptian banking sector. Consequently, this study clarifies this beneficial relationship, which may have significant implications for restoring the challenges faced by the Egyptian economy following the critical events it went through, which, in turn, impacted the country’s poor and vulnerable.
Diagnosis, clinical symptoms and treatment of Hakim-Adams syndrome
Authors: Kozikowska Marta , Pociecha Agnieszka , Kmak Bożena 
Published: August 2024

Introduction and purpose
Normal pressure hydrocephalus (NPH) is a chronic and progressive neurological disorder that affects the accumulation of cerebrospinal fluid (CSF) in the brain's ventricles. The disease is not limited by age, but it is more prevalent in older adults. The accumulation of excess CSF in the brain's ventricles is caused by the obstruction of normal CSF flow, leading to an enlargement of the ventricles and pressure on brain structures. NPH manifests as cognitive disorders, gait disorders, and urinary incontinence. NPH is considered a potentially reversible cause of dementia. This study aims to discuss the etiology, symptoms, differential diagnosis, and treatment methods associated with normotensive hydrocephalus.

Materials and methods
A comprehensive literature review was conducted through an extensive bibliographic search, with a primary focus on original research articles obtained from reputable databases such as PubMed, BioMed Central, Polish Medical Platform, and Google Scholar. The search was specifically targeted towards articles pertaining to Normal Pressure Hydrocephalus (NPH).

Conclusions
Normotensive hydrocephalus (NPH) is a complex neurological condition that is characterized by an imbalance between the production and absorption of cerebrospinal fluid (CSF). NPH is classified into idiopathic and secondary types, which helps to determine the possible underlying causes and mechanisms that contribute to the development of the condition. The clinical manifestations of NPH are highly variable, and the diagnostic process can be complicated due to the need to differentiate it from other neurodegenerative disorders. Underdiagnosis or misdiagnosis is common, leading to a decrease in patients' quality of life and, in many cases, disability.
The prevalence of NPH is increasing, highlighting the need for further research and the development of novel therapeutic approaches to improve patient outcomes.
Chronic Fatigue Syndrome: Insights and Treatment Perspectives – a literature review
Authors: Ślesicka Iga , Przestrzelska Magda , Zozula Natalia , Tomczewska Zuzanna , Rykucka Aleksandra , Wąs Marcin , Latała Aleksandra , Kiełbasa Justyna , Kowalczyk Agata , Bil Katarzyna 
Published: August 2024

Introduction: Chronic Fatigue Syndrome (CFS) is an exhausting continuous medical condition. In most cases it affects patients after a flu-like infection. CFS correlates with alterations in the nervous and immune systems, metabolism, and hormone secretion. Diagnostic process is very challenging due to the absence of a definitive diagnostic test and wide symptomatology. It negatively impacts people's both mental and physical health.
Aim of the study: The aim of this literature review is to comprehensively examine current research findings and literature on Chronic Fatigue Syndrome (CFS), understand its etiology, how it affects the body, why it's challenging to diagnose, the various treatments available, new ideas and viewpoints in the field.Describing the State of Knowledge: Despite extensive investigation, the exact etiology of CFS remains unknown. In literature CFS is also often described as Myalgic Encephalomyelitis. In the WHO's most recent classification, the ICD-11, both Chronic Fatigue Syndrome and Myalgic Encephalomyelitis are classified as “other disorders of the nervous system” which indicates the significance of the issue.
Conclusions: This literature review underlines the importance of a comprehensive and collaborative approach in addressing the complexities of CFS and improving outcomes for individuals living with this debilitating condition.
Optic neuritis – general overview with particular emphasis on differential diagnosis
Authors: Nowak Aleksandra , Janus Anita , Kaptur Agata , Dziedziński Dawid , Kwaśniewska Oliwia , Łoś Dawid 
Published: August 2024

Introduction and purpose

Optic neuritis (ON), especially retrobulbar, is a common inflammatory neuropathy of the optic nerve occurring typically in young adults. This neuro-ophthalmological condition is involved in the clinical picture of multiple diseases and may be frequently a heralding symptom of them [1,2,3,4,5,7,13].
The main aim of this review is to provide clinicians with thorough information on the possible etiologies of ON, its differentiation and management.

Review Methods

For this report, we conducted a research of the available, most recent literature in Pubmed and medical books using the keywords (below). As a result, we included over 30 articles and chapters as a benchmark of our analysis.

A brief description of the State of Knowledge

Optic neuritis is a frequent manifestation of many diseases, with a particular focus on demyelinating processes [1,2,3,4,5,7,13]. Its incidence in central Europe is about 5 per 100 000 people per year [26]. Although the symptoms may be very severe including even abrupt vision loss or intense pain on ocular movement, the prognosis regarding future visual acuity is generally good [1,2,9]. In contrast, the spectrum of diseases underlying optic neuritis is much more diverse [9,10,13,25].

Summary

Although a definite diagnosis is not always possible when looking for the cause of ON, it is crucial to know the possible etiologies and to differentiate them as much as we can by means of commonly used tools. In this way, a correct diagnosis will lead to earlier, more personalized treatment and a better overall prognosis [1,5,9,10,11,15,25].