bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prediction and structural equation model of sertraline treatment response in Japanese patients with major depressive disorder
Authors: Nishioka Gentaro , Yashima Hideaki , Kiuchi Yuji , Nakamura Sumiko , Oyamada Hideto , Ishii Masakazu , Kudo Ikuo 
Published: October 2013

ObjectiveThe aim of this study was to extract the factors possibly associated with sertraline treatment response and elucidate their interactions and extent of influence.MethodsDemographic state, stress state, personality, and eight genetic polymorphisms at baseline and clinical symptoms at baseline and 8 weeks were analyzed and examined by logistic regression and a structural equation model in sertraline treatment study of 96 Japanese patients with major depressive disorder.ResultsNon‐responders were associated with higher scores of harm avoidance in Temperament and Character Inventory, higher scores (≥24) of 17‐item Hamilton Rating Scale for Depression at baseline, recurrence, and 12/12 genotype of the serotonin transporter variable number of tandem repeat polymorphism in intron 2 (5HTTSTin2). When we calculated the response index using four factors extracted, the mean response index value of non‐responders was significantly higher than that of responders. The symptoms at baseline, personality, recurrence, and polymorphism of 5HTTSTin2 showed significantly direct and positive influences on the symptoms at 8 weeks in our final structural equation model with a good model fit.ConclusionConsidering the combination of four factors extracted may be useful for predicting a worse response to sertraline treatment and selecting different treatment other than sertraline. Copyright © 2013 John Wiley & Sons, Ltd.
River evaporation and corresponding heat fluxes in forested catchments
Authors: Maheu Audrey , Caissie Daniel , St‐Hilaire André , El‐Jabi Nassir 
Published: October 2013

AbstractRiver water temperature is a very important variable in ecological studies, especially for the management of fisheries and aquatic resources. Temperature can impact on fish distribution, growth, mortality and community dynamics. River evaporation has been identified as an important heat loss and a key process in the thermal regime of rivers. However, its quantification remains a challenge, mainly because of the difficulty of making direct measurements. The objectives of this study were to characterize the evaporative heat flux at different scales (brook vs river) and to improve the estimation of the evaporative heat flux in a stream temperature model at the hourly timescale. Using a mass balance approach with floating minipans, we measured river evaporation at an hourly timescale in a medium‐sized river (Little Southwest Miramichi) and a small brook (Catamaran Brook) in New Brunswick, Canada. With these direct measurements of evaporation, we developed mass transfer equations to estimate hourly evaporation rates from microclimate conditions measured 2 m above the stream. During the summer 2012, river evaporation was more important for the medium‐sized river with a mean daily evaporation rate of 3.0 mm day−1 in the Little Southwest Miramichi River compared with that of 1.0 mm day−1 in Catamaran Brook. Evaporation was the main heat loss mechanism in the two studied streams and was responsible for 42% of heat losses in the Little Southwest Miramichi River and 34% of heat losses in Catamaran Brook during the summer. Copyright © 2013 John Wiley & Sons, Ltd.
Effects of lakes and reservoirs on annual river nitrogen, phosphorus, and sediment export in agricultural and forested landscapes
Authors: Powers S. M. , Robertson D. M. , Stanley E. H. 
Published: October 2013

AbstractRecently, effects of lakes and reservoirs on river nutrient export have been incorporated into landscape biogeochemical models. Because annual export varies with precipitation, there is a need to examine the biogeochemical role of lakes and reservoirs over time frames that incorporate interannual variability in precipitation. We examined long‐term (~20 years) time series of river export (annual mass yield, Y, and flow‐weighted mean annual concentration, C) for total nitrogen (TN), total phosphorus (TP), and total suspended sediment (TSS) from 54 catchments in Wisconsin, USA. Catchments were classified as small agricultural, large agricultural, and forested by use of a cluster analysis, and these varied in lentic coverage (percentage of catchment lake or reservoir water that was connected to river network). Mean annual export and interannual variability (CV) of export (for both Y and C) were higher in agricultural catchments relative to forested catchments for TP, TN, and TSS. In both agricultural and forested settings, mean and maximum annual TN yields were lower in the presence of lakes and reservoirs, suggesting lentic denitrification or N burial. There was also evidence of long‐term lentic TP and TSS retention, especially when viewed in terms of maximum annual yield, suggesting sedimentation during high loading years. Lentic catchments had lower interannual variability in export. For TP and TSS, interannual variability in mass yield was often >50% higher than interannual variability in water yield, whereas TN variability more closely followed water (discharge) variability. Our results indicate that long‐term mass export through rivers depends on interacting terrestrial, aquatic, and meteorological factors in which the presence of lakes and reservoirs can reduce the magnitude of export, stabilize interannual variability in export, as well as introduce export time lags. Copyright © 2013 John Wiley & Sons, Ltd.
Maximizing the accuracy of field-derived numeric nutrient criteria in water quality regulations
Authors: McLaughlin Douglas B 
Published: October 2013

Abstract
High levels of the nutrients nitrogen and phosphorus can cause unhealthy biological or ecological conditions in surface waters and prevent the attainment of their designated uses. Regulatory agencies are developing numeric criteria for these nutrients in an effort to ensure that the surface waters in their jurisdictions remain healthy and productive, and that water quality standards are met. These criteria are often derived using field measurements that relate nutrient concentrations and other water quality conditions to expected biological responses such as undesirable growth or changes in aquatic plant and animal communities. Ideally, these numeric criteria can be used to accurately “diagnose” ecosystem health and guide management decisions. However, the degree to which numeric nutrient criteria are useful for decision making depends on how accurately they reflect the status or risk of nutrient-related biological impairments. Numeric criteria that have little predictive value are not likely to be useful for managing nutrient concerns. This paper presents information on the role of numeric nutrient criteria as biological health indicators, and the potential benefits of sufficiently accurate criteria for nutrient management. In addition, it describes approaches being proposed or adopted in states such as Florida and Maine to improve the accuracy of numeric criteria and criteria-based decisions. This includes a preference for developing site-specific criteria in cases where sufficient data are available, and the use of nutrient concentration and biological response criteria together in a framework to support designated use attainment decisions. Together with systematic planning during criteria development, the accuracy of field-derived numeric nutrient criteria can be assessed and maximized as a part of an overall effort to manage nutrient water quality concerns. Integr Environ Assess Manag 2014;10:133–137. © 2013 SETAC
LE RESPECT DES DROITS D'EAU LORS DE LA REHABILITATION DES PERIMETRES TRADITIONNELS AU MAROC
Authors: Plusquellec Herve , Bachri Mohammed 
Published: October 2013

ABSTRACTTraditional irrigation sector covering about 300,000 hectares accounts for about 20 percent of the total irrigated area in Morocco. Traditional irrigation schemes developed since immemorial times, although of rustic appearance, are managed according to sophisticated rules of water allocation and distribution. This paper discusses these rules which depend on the nature of water resources (springs, perennial flows and floods), crops and traditional water rights. The paper then presents the actions taken to improve performance of about 80 schemes including physical improvements and intensive training of user associations, while conserving traditional water rights. These works were carried out under the Irrigated Fruit‐tree (PAF) Project financed by the Millenium Challenge Corporation (MCC), of which the original approach is the improvement of the value‐chains of olive trees and palm‐trees from the productivity of the trees to marketing. The project covers a total irrigated area of 53,000 ha of which 20,000 ha in oasis areas and 33,000 ha in areas of small and medium‐scale irrigation. Studies and works were carried out in very diverse area where each scheme has its own characteristics and the social environment responds to specific traditional rules. Copyright © 2013 John Wiley & Sons, Ltd.
NONLINEAR FORECASTING OF THE GOLD MINER SPREAD: AN APPLICATION OF CORRELATION FILTERS
Authors: Dunis Christian L. , Laws Jason , Middleton Peter W. , Karathanasopoulos Andreas 
Published: October 2013

SUMMARYThis paper models and forecasts the Gold Miner Spread from 23 May 2006 to 30 June 2011. The Gold Miner Spread acts as a suitable performance indicator for the relationship between physical gold and US gold equity.The contribution of this investigation is twofold. First, the accuracy of each model is evaluated from a statistical perspective. Second, various forecasting methodologies are then applied to trade the spread. Trading models include an ARMA (12,12) model, a cointegration model, a multilayer perceptron neural network (NN), a particle swarm optimization radial basis function NN and a genetic programming algorithm (GPA).Results obtained from an out‐of‐sample trading simulation validate the in‐sample back test as the GPA model produced the highest risk‐adjusted returns. Correlation filters are also applied to enhance performance and, as a consequence, volatility is reduced by 5%, on average, while returns are improved between 2.54% and 8.11% across five of the six models. Copyright © 2013 John Wiley & Sons, Ltd.
A SIMULATION ANALYSIS OF HERDING AND UNIFRACTAL SCALING BEHAVIOUR
Authors: Phelps Steve , Ng Wing Lon 
Published: October 2013

SUMMARYWe model the financial market using a class of agent‐based models in which agents’ expectations are driven by heuristic forecasting rules (in contrast to the rational expectations models used in traditional theories of financial markets). We show that, within this framework, we can reproduce unifractal scaling with respect to three well‐known power laws relating (i) moments of the absolute price change to the time‐scale over which they are measured, (ii) magnitude of returns with respect to their probability and (iii) the autocorrelation of absolute returns with respect to lag. In contrast to previous studies, we systematically analyse all three power laws simultaneously using the same underlying model by making observations at different time‐scales and higher moments. We show that the first two scaling laws are remarkably robust to the time‐scale over which observations are made, irrespective of the model configuration. However, in contrast to previous studies, we show that herding may explain why long memory is observed at all frequencies. Copyright © 2013 John Wiley & Sons, Ltd.
Catastrophizing mediates the relationship between fear of pain and preference for elective caesarean section
Authors: Dehghani M. , Sharpe L. , Khatibi A. 
Published: October 2013

AbstractBackgroundFear of childbirth is associated with preference for an elective caesarean section (ECS); however, the role of fear of pain and pain catastrophizing (the tendency to predict the worst case scenario) have not been investigated. The aim of current study was to investigate whether fear of pain and catastrophizing were independent predictors of preference for ECS. We hypothesized that pain catastrophizing and negative affectivity would mediate the relationship between fear of pain and preference for ECS.MethodsThree hundred pregnant women between 4 and 36 weeks of gestation were asked to indicate whether they would prefer to deliver their baby through an ECS or a vaginal delivery. They were also asked to complete a battery of questionnaires assessing demographic details, mood, fear of childbirth, fear of pain and catastrophizing. Consistent with cultural norms, more than half of the women preferred an ECS (58%).ResultsWomen who chose ECS were more likely to seek private obstetric care, have had a previous caesarean section and have higher levels of fear of childbirth, fear of pain, more catastrophic cognitions and lower mood. Catastrophizing, but not negative affectivity, mediated the relationship between fear of pain and preference for ECS, as predicted.ConclusionsFear of both childbirth and pain were both independent predictors of preference for ECS. Catastrophizing mediated the relationship between fear of pain and preference for ECS. Interventions that target these factors may reduce the trend towards increasing numbers of ECS internationally.
The effects of goal setting, contingent reward, and instruction on writing skills
Authors: Hansen Blake D. , Wills Howard P. 
Published: October 2013

AbstractWriting is one of the primary skills that children learn in school. Interventions that address performance deficits and skill deficits have been shown to improve aspects of elementary school children's writing. This study demonstrates performance‐based interventions (goal setting, feedback, and contingent reward) and a skill‐based intervention (instruction) on the writing skills of a 10‐year‐old child. Results indicated that the performance intervention increased the number of correctly spelled words, and the combination of performance and instructional intervention increased the number of complete sentences.
ESTIMATING PERSON‐CENTERED TREATMENT (PeT) EFFECTS USING INSTRUMENTAL VARIABLES: AN APPLICATION TO EVALUATING PROSTATE CANCER TREATMENTS
Authors: Basu Anirban 
Published: October 2013

SUMMARYThis paper builds on the methods of local instrumental variables developed by Heckman and Vytlacil (1999, 2001, 2005) to estimate person‐centered treatment (PeT) effects that are conditioned on the person's observed characteristics and averaged over the potential conditional distribution of unobserved characteristics that lead them to their observed treatment choices. PeT effects are more individualized than conditional treatment effects from a randomized setting with the same observed characteristics. PeT effects can be easily aggregated to construct any of the mean treatment effect parameters and, more importantly, are well suited to comprehend individual‐level treatment effect heterogeneity. The paper presents the theory behind PeT effects, and applies it to study the variation in individual‐level comparative effects of prostate cancer treatments on overall survival and costs. Copyright © 2013 John Wiley & Sons, Ltd.
Towards an integrated in vitro strategy for estrogenicity testing
Authors: Wang Si , Aarts Jac M. M. J. G. , de Haan Laura H. J. , Argyriou Dimitrios , Peijnenburg Ad A. C. M. , Rietjens Ivonne M. C. M. , Bovee Toine F. H. 
Published: October 2013

ABSTRACTIn order to define an in vitro integrated testing strategy (ITS) for estrogenicity, a set of 23 reference compounds representing diverse chemical classes were tested in a series of in vitro assays including proliferation and reporter gene assays. Outcomes of these assays were combined with published results for estrogen receptor (ER) binding assays and the OECD validated BG1Luc ER transcriptional activation (TA) assay and compared with the outcomes of the in vivo uterotrophic assay to investigate which assays most accurately predict the in vivo uterotrophic effect and to identify discrepancies between the in vitro assays and the in vivo uterotrophic assay. All in vitro assays used revealed a reasonable to good correlation (R2 = 0.62–0.87) with the in vivo uterotrophic assay but the combination of the yeast estrogen bioassay with the U2OS ERα‐CALUX assay seems most promising for an ITS for in vitro estrogenicity testing. The main outliers identified when correlating data from the different in vitro assays and the in vivo uterotrophic assay were 4‐hydroxytamoxifen, testosterone and to a lesser extent apigenin, tamoxifen and kepone. Based on the modes of action possibly underlying these discrepancies it becomes evident that to further improve the ITS and ultimately replace animal testing for (anti‐)estrogenic effects, the selected bioassays have to be combined with other types of in vitro assays, including for instance in vitro models for digestion, bioavailability and metabolism of the compounds under investigation. Copyright © 2013 John Wiley & Sons, Ltd.
Comparison of toxicity of different nanorod‐type TiO2 polymorphs in vivo and in vitro
Authors: Park Eun‐Jung , Lee Gwang‐Hee , Shim Hyun‐Woo , Kim Jae‐Ho , Cho Myung‐Haing , Kim Dong‐Wan 
Published: October 2013

ABSTRACTIt is predicted that the toxicity of nanoparticles may be different depending on the properties of the nanoparticles and biological system being tested. However, the factors that influence the toxicity of nanoparticles have not been adequately investigated. In this study, we characterized two types of TiO2 nanorods, anatase (ATO) and brookite (BTO), and compared their toxicity in vivo and in vitro. ATO and BTO differed from each other most notably in their surface areas. Treatment with the two TiO2 nanorods (10 µg ml–1) produced similar effects on the cell cycle in eight cell lines which are derived from potential target organs of nanoparticles, with the BTO eliciting stronger responses than ATO in all cell lines, among the cell lines, H9C2 showed the maximal change. Similarly, when mice were exposed to two TiO2 nanorods (1 mg kg–1), BTO induced clearer histopathological lesions and triggered a more robust secretion of inflammatory cytokines than ATO. Furthermore, we compared the cellular response of both TiO2 nanorods using BEAS‐2B cells, the human bronchial epithelial cell line. Both nanorods induced cell death by increasing the formation of autophagosome‐like vacuoles. The mitochondrial calcium concentration decreased by exposure of both types, but the distribution of lysosome and endoplasmic reticulum (ER) showed a clear difference between the two nanorods. Thus, we conclude that the surface area acts as an important factor which depends on toxicity of nanorod type‐TiO2 nanoparticles. Furthermore, the toxicity of nanoparticles varies according to the type of cells tested, and that the assembly of autophagosome‐like vacuoles is a critical part of the cellular response to nanoparticle exposure. Copyright © 2013 John Wiley & Sons, Ltd.
Histopathological findings on Carassius auratus hepatopancreas upon exposure to acrylamide: correlation with genotoxicity and metabolic alterations
Authors: Larguinho Miguel , Costa Pedro M. , Sousa Gonçalo , Costa Maria H. , Diniz Mário S. , Baptista Pedro V. 
Published: October 2013

ABSTRACTAcrylamide is an amide used in several industrial applications making it easily discharged to aquatic ecosystems. The toxicity of acrylamide to aquatic organisms is scarcely known, although previous studies with murine models provided evidence for deleterious effects. To assess the effects of acrylamide to freshwater fish, goldfish (Carassius auratus L.) were exposed to several concentrations of waterborne acrylamide and analysed for genotoxic damage, alterations to detoxifying enzymes and histopathology. Results revealed a dose‐dependent increase in total DNA strand breakage, the formation of erythrocytic nuclear abnormalities and in the levels of hepatic cytochrome P4501A (CYP1A) and glutathione S‐transferase (GST) activity. In addition, acrylamide induced more histopathological changes to pancreatic acini than to the hepatic parenchyma, regardless of exposure concentration, whereas hepatic tissue only endured significant alterations at higher concentrations of exposure. Thus, results confirm the genotoxic potential of acrylamide to fish and its ability to induce CYP1A, probably as a direct primary defence mechanism. This strongly suggests the substance's pro‐mutagenic potential in fish, similarly to what is known for rodents. However, the deleterious effects observed in the pancreatic acini, more severe than in the liver, could indicate a specific, albeit unknown toxic mechanism of acrylamide to fish that overran the organism's metabolic defences against a chemical agent rather than causing a general systemic failure. Copyright © 2013 John Wiley & Sons, Ltd.
A catch‐up validation study of an in vitro skin irritation test method using reconstructed human epidermis LabCyte EPI‐MODEL24
Authors: Kojima Hajime , Katoh Masakazu , Shinoda Shinsuke , Hagiwara Saori , Suzuki Tamie , Izumi Runa , Yamaguchi Yoshihiro , Nakamura Maki , Kasahawa Toshihiko , Shibai Aya 
Published: October 2013

ABSTRACTThree validation studies were conducted by the Japanese Society for Alternatives to Animal Experiments in order to assess the performance of a skin irritation assay using reconstructed human epidermis (RhE) LabCyte EPI‐MODEL24 (LabCyte EPI‐MODEL24 SIT) developed by the Japan Tissue Engineering Co., Ltd. (J‐TEC), and the results of these studies were submitted to the Organisation for Economic Co‐operation and Development (OECD) for the creation of a Test Guideline (TG). In the summary review report from the OECD, the peer review panel indicated the need to resolve an issue regarding the misclassification of 1‐bromohexane. To this end, a rinsing operation intended to remove exposed chemicals was reviewed and the standard operating procedure (SOP) revised by J‐TEC. Thereafter, in order to confirm general versatility of the revised SOP, a new validation management team was organized by the Japanese Center for the Validation of Alternative Methods (JaCVAM) to undertake a catch‐up validation study that would compare the revised assay with similar in vitro skin irritation assays, per OECD TG No. 439 (2010). The catch‐up validation and supplementary studies for LabCyte EPI‐MODEL24 SIT using the revised SOPs were conducted at three laboratories. These results showed that the revised SOP of LabCyte EPI‐MODEL24 SIT conformed more accurately to the classifications for skin irritation under the United Nations Globally Harmonised System of Classification and Labelling of Chemicals (UN GHS), thereby highlighting the importance of an optimized rinsing operation for the removal of exposed chemicals in obtaining consistent results from in vitro skin irritation assays. Copyright © 2013 John Wiley & Sons, Ltd.