bluuebunny/crossref_metadata_2025_split huggingface dataset:
Évaluation des étudiants infirmiers en situation simulée : en quête de sens et d'éthique
Authors: Homerin Marie-Pierre , Roumanet Marie-Cécile 
Published: October 2014

Un questionnement autour de l’évaluation en situation simulée 1 est à l’origine de cette recherche-action menée au sein de l’IFSI de Savoie. En effet, les différences de modalités d’évaluation selon les unités d’enseignement qui prévoient ce genre de validation ainsi que le taux de réussite insatisfaisant lors de ces mises en situations simulées ont amené des formatrices à poser la question suivante : « Comment, lors de ces évaluations, donner du sens et être cohérent par rapport à la finalité de la formation (Former des praticiens autonomes et réflexifs) » ? Ce questionnement a été éclairé à l’aide de concepts tels que le socioconstructivisme, la simulation en santé, l’évaluation et avec l’apport théorique des principes éthiques. La modification des pratiques a consisté en l’application des principes de l’évaluation formatrice selon G. Nunziatti en impliquant fortement les étudiants dans le processus d’évaluation. Pour évaluer l’impact de ces changements de pratiques, un questionnaire anonyme en ligne a été proposé à l’ensemble des étudiants qui ont bénéficié de ce type d’évaluation. Les résultats de deux promotions d’étudiants qui n’ont pas eu les mêmes modalités d’évaluation ont également été comparés. Les objectifs poursuivis étaient de mesurer la satisfaction des étudiants, de comparer les taux d’échec obtenus selon les différentes méthodes de validation en situation simulée et d’apprécier le respect des principes éthiques, lors de la mise en œuvre d’une évaluation de type formatrice. Cette étude a montré la satisfaction des étudiants face à ces nouvelles modalités d’évaluation en situation simulée, une meilleure réussite aux épreuves et la possibilité d’appliquer les principes éthiques à cette façon de procéder. Cependant, les principes de justice et de non malfaisance restent difficiles à mettre en œuvre. Cette réflexion sur les modalités d’évaluation en situation simulée a permis de faire évoluer les pratiques et la conception de l’évaluation chez les formateurs.
Développement professionnel infirmier en promotion de la santé
Authors: Hardy Anne-France , Eneau Jérôme , Nagels Marc 
Published: October 2014

Cette recherche se propose d’éclairer le développement professionnel du personnel infirmier éducateur de santé en milieu scolaire. Les missions d’éducation et de promotion de la santé relèvent du savoir spécifique infirmier et correspondent, en dehors du champ habituel de la prescription, aux pratiques relevant du rôle propre. L’hypothèse d’un lien entre rôle spécifiquement infirmier et développement professionnel guide ce travail. L’étude compare (N=30) des approches professionnelles d’infirmières d’établissement d’enseignements en poste sur le département d’« Ille-et-Vilaine ». L’expérience des acteurs est interrogée pour tenter de dégager les éléments de ce développement professionnel autour de trois indicateurs clés : la posture, les dynamiques identitaires et la dimension collective de l’activité. L’enquête de type qualitative emprunte les outils d’une méthode hybride qui recourt à l’analyse parallèle de contenus recueillis sous deux modalités différentes : l’entretien compréhensif et l’écrit réflexif.
Impossible négociation ?
Authors: Sartori Enrica 
Published: October 2014

Résumé Ancien ambassadeur de France, Stéphane Hessel a mis, à 79 ans, son expérience de la négociation au service des sans-papiers de Saint-Bernard, en participant au collège des médiateurs créé à l’initiative d’Ariane Mnouchkine. Mais comment jouer les intermédiaires lorsque l’un des interlocuteurs refuse de reconnaître l’existence même de l’autre ? Gilles Deleuze écrivait : « si modeste que soit une revendication, elle présente toujours un point que le pouvoir ne peut supporter, lorsque les gens réclament de poser eux-mêmes leurs propres problèmes. » Quelle place, alors, pour la négociation ?
Zacage dans le XXème
Authors: Glatron Sandrine , Nahapétian Naïri 
Published: October 2014

Résumé	La rénovation de pans entiers du 20e arrondissement de Paris est censé participer à l’éternel embellissement de la capitale idéale des touristes. La mairie de Paris dispose de nombreux instruments pour mener à bien cette tâche. Les habitants s’en créent d’autres pour y faire face.
Il paraît que le mouvement gai a 100 ans...
Authors: Celse Michel 
Published: October 2014

Résumé	La communauté gaie a toutes raisons de s’intéresser aujourd’hui à son histoire, et nul doute que la conquête d’une sorte de « droit à l’histoire » représente pour elle, depuis 25 ans, un enjeu politique majeur. La partie est pourtant loin d’être gagnée. Le bilan de cette lutte, pour l’heure, reste désastreux, particulièrement en France.
Altered Peptide Ligands Revisited: Vaccine Design through Chemically Modified HLA-A2–Restricted T Cell Epitopes
Authors: Hoppes Rieuwert , Oostvogels Rimke , Luimstra Jolien J. , Wals Kim , Toebes Mireille , Bies Laura , Ekkebus Reggy , Rijal Pramila , Celie Patrick H. N. , Huang Julie H. , Emmelot Maarten E. , Spaapen Robbert M. , Lokhorst Henk , Schumacher Ton N. M. , Mutis Tuna , Rodenko Boris , Ovaa Huib 
Published: October 2014

Abstract
Virus or tumor Ag–derived peptides that are displayed by MHC class I molecules are attractive starting points for vaccine development because they induce strong protective and therapeutic cytotoxic T cell responses. In thus study, we show that the MHC binding and consequent T cell reactivity against several HLA-A*02 restricted epitopes can be further improved through the incorporation of nonproteogenic amino acids at primary and secondary anchor positions. We screened more than 90 nonproteogenic, synthetic amino acids through a range of epitopes and tested more than 3000 chemically enhanced altered peptide ligands (CPLs) for binding affinity to HLA-A*0201. With this approach, we designed CPLs of viral epitopes, of melanoma-associated Ags, and of the minor histocompatibility Ag UTA2-1, which is currently being evaluated for its antileukemic activity in clinical dendritic cell vaccination trials. The crystal structure of one of the CPLs in complex with HLA-A*0201 revealed the molecular interactions likely responsible for improved binding. The best CPLs displayed enhanced affinity for MHC, increasing MHC stability and prolonging recognition by Ag-specific T cells and, most importantly, they induced accelerated expansion of antitumor T cell frequencies in vitro and in vivo as compared with the native epitope. Eventually, we were able to construct a toolbox of preferred nonproteogenic residues with which practically any given HLA-A*02 restricted epitope can be readily optimized. These CPLs could improve the therapeutic outcome of vaccination strategies or can be used for ex vivo enrichment and faster expansion of Ag-specific T cells for transfer into patients.
Uncovering the Peptide-Binding Specificities of HLA-C: A General Strategy To Determine the Specificity of Any MHC Class I Molecule
Authors: Rasmussen Michael , Harndahl Mikkel , Stryhn Anette , Boucherma Rachid , Nielsen Lise Lotte , Lemonnier François A. , Nielsen Morten , Buus Søren 
Published: October 2014

Abstract
MHC class I molecules (HLA-I in humans) present peptides derived from endogenous proteins to CTLs. Whereas the peptide-binding specificities of HLA-A and -B molecules have been studied extensively, little is known about HLA-C specificities. Combining a positional scanning combinatorial peptide library approach with a peptide–HLA-I dissociation assay, in this study we present a general strategy to determine the peptide-binding specificity of any MHC class I molecule. We applied this novel strategy to 17 of the most common HLA-C molecules, and for 16 of these we successfully generated matrices representing their peptide-binding motifs. The motifs prominently shared a conserved C-terminal primary anchor with hydrophobic amino acid residues, as well as one or more diverse primary and auxiliary anchors at P1, P2, P3, and/or P7. Matrices were used to generate a large panel of HLA-C–specific peptide-binding data and update our pan-specific NetMHCpan predictor, whose predictive performance was considerably improved with respect to peptide binding to HLA-C. The updated predictor was used to assess the specificities of HLA-C molecules, which were found to cover a more limited sequence space than HLA-A and -B molecules. Assessing the functional significance of these new tools, HLA-C*07:01 transgenic mice were immunized with stable HLA-C*07:01 binders; six of six tested stable peptide binders were immunogenic. Finally, we generated HLA-C tetramers and labeled human CD8+ T cells and NK cells. These new resources should support future research on the biology of HLA-C molecules. The data are deposited at the Immune Epitope Database, and the updated NetMHCpan predictor is available at the Center for Biological Sequence Analysis and the Immune Epitope Database.
Intraclonal Diversity in Follicular Lymphoma Analyzed by Quantitative Ultradeep Sequencing of Noncoding Regions
Authors: Spence Janice M. , Abumoussa Andrew , Spence John P. , Burack W. Richard 
Published: October 2014

Abstract
Cancers are characterized by genomic instability, and the resulting intraclonal diversity is a prerequisite for tumor evolution. Therefore, metrics of tumor heterogeneity may prove to be clinically meaningful. Intraclonal heterogeneity in follicular lymphoma (FL) is apparent from studies of somatic hypermutation (SHM) caused by activation-induced deaminase (AID) in IGH. Aberrant SHM (aSHM), defined as AID activity outside of the IG loci, predominantly targets noncoding regions causing numerous “passenger” mutations, but it has the potential to generate rare significant “driver” mutations. The quantitative relationship between SHM and aSHM has not been defined. To measure SHM and aSHM, ultradeep sequencing (&gt;20,000-fold coverage) was performed on IGH (∼1650 nt) and nine other noncoding regions potentially targeted by AID (combined 9411 nt), including the 5′ untranslated region of BCL2. Single-nucleotide variants (SNVs) were found in 12/12 FL specimens (median 136 SHMs and 53 aSHMs). The aSHM SNVs were associated with AID motifs (p &lt; 0.0001). The number of SNVs at BCL2 varied widely among specimens and correlated with the number of SNVs at eight other potential aSHM sites. In contrast, SHM at IGH was not predictive of aSHM. Tumor heterogeneity is apparent from SNVs at low variant allele frequencies; the relative number of SNVs with variable allele frequency &lt; 5% varied with clinical grade, indicating that tumor heterogeneity based on aSHM reflects a clinically meaningful parameter. These data suggest that genome-wide aSHM may be estimated from aSHM of BCL2 but not SHM of IGH. The results demonstrate a practical approach to the quantification of intratumoral genetic heterogeneity for clinical specimens.
Prevalence of cigarette smoking and its predictors among school going adolescents of North India
Authors: Thakur Durgesh , Gupta Anmol , Thakur Anita , Mazta Salig Ram , Sharma Deepak 
Published: October 2014

Abstract
Background: Cigarettes smoking is a common mode of consuming tobacco in India. This habit usually starts in adolescence and tracks across the life course. Interventions like building decision making skills and resisting negative influences are effective in reducing the initiation and level of tobacco use. Aims and Objectives: The purpose of this study was to assess the prevalence of adolescent current cigarette smoking behavior and to investigate the individual and social factors, which influence them both to and not to smoke. Methodology: A cross-sectional study was carried out among school going adolescents in Shimla town of North India. After obtaining their written informed consent, a questionnaire was administered. Results: The overall prevalence of current cigarette smoking was 11.8%. The binary logistic regression model revealed that parents′ and peers′ smoking behavior influence adolescent smoking behavior. Individual self-harm tendency also significantly predicted cigarette smoking behavior. Parental active participation in keeping a track of their children′s free time activities predicted to protect adolescents from taking this habit. Conclusion: Our research lends support to the need for intervention on restricting adolescents from taking up this habit and becoming another tobacco industries′ addicted customer. Parents who smoke should quit this habit, which will not only restore their own health, but also protect their children. All parents should be counseled to carefully observe their children′s free time activities.
De publiek- en privaatrechtelijke handhaving van het Europese privaatrecht: de nieuwe realiteit voor contracteren
Authors: Cherednychenko O.O. 
Published: October 2014

De publiek- en privaatrechtelijke handhaving van het Europese privaatrecht: de nieuwe realiteit voor contracteren
In toenemende mate worden private verhoudingen op de terreinen die door het Europese privaatrecht worden beheerst aan het publieke toezicht onderworpen en de gedragsregels voor contractspartijen langs de bestuursrechtelijke weg gehandhaafd. Daarnaast wordt de rol van de alternatieve geschillenbeslechting steeds belangrijker. Deze ontwikkelingen brengen een nieuwe realiteit mee voor contracteren in de gereguleerde sectoren. Recent werd de internationale conferentie getiteld Public and Private Enforcement of European Private Law: Perspectives and Challenges (gehouden aan de Rijksuniversiteit Groningen) gewijd aan deze problematiek. In deze bijdrage voor de rubriek Impressies wordt stilgestaan bij enkele interessante bevindingen en leerzame suggesties die tijdens de conferentie naar voren zijn gekomen.
Peripheral Blood-Derived Mesenchymal Stromal Cells Promote Angiogenesis via Paracrine Stimulation of Vascular Endothelial Growth Factor Secretion in the Equine Model
Authors: Bussche Leen , Van de Walle Gerlinde R. 
Published: October 2014

AbstractMesenchymal stromal cells (MSCs) have received much attention as a potential treatment of ischemic diseases, including ischemic tissue injury and cardiac failure. The beneficial effects of MSCs are thought to be mediated by their ability to provide proangiogenic factors, creating a favorable microenvironment that results in neovascularization and tissue regeneration. To study this in more detail and to explore the potential of the horse as a valuable translational model, the objectives of the present study were to examine the presence of angiogenic stimulating factors in the conditioned medium (CM) of peripheral blood-derived equine mesenchymal stromal cells (PB-MSCs) and to study their in vitro effect on angiogenesis-related endothelial cell (EC) behavior, including proliferation and vessel formation. Our salient findings were that CM from PB-MSCs contained significant levels of several proangiogenic factors. Furthermore, we found that CM could induce angiogenesis in equine vascular ECs and confirmed that endothelin-1, insulin growth factor binding protein 2, interleukin-8, and platelet-derived growth factor-AA, but not urokinase-type plasminogen activator, were responsible for this enhanced EC network formation by increasing the expression level of vascular endothelial growth factor-A, an important angiogenesis stimulator.
Shareholdings in Financial Institutions, Financing Constraints, and Cash Reserves1
Authors: Zhu Song , Chen Guanting , Du Wencui 
Published: October 2014

Abstract
A closer bank-firm relationship is beneficial to corporate development since firms are able to mitigate their financing constraints through direct or indirect means, such as related-party loans or signalling. This results in more firms tending to invest in financial institutions. This paper matches 615 firms investing in nonlisted financial institutions over the period 2007 to 2011 with 615 firms of the closest asset size in the same industry and year but without such investment. We find that investing in financial institutions can be beneficial for firms. It can lower the financing constraints and demand for cash reserves, not only directly (due to the close relationship between holding firms and financial institutions), but also indirectly (due to the influence on financing constraints, which require a higher level of cash holdings). Higher financing constraints will stimulate firms to hold more cash, while investing in financial institutions can enable such firms to reduce their reserves. When we divide the shareholdings further into nonlisted banks and nonlisted, nonbanking institutions, we find that the former does not significantly affect financing constraints and cash holdings, but the latter effectively alleviates firms’ financing constraints and reduces the level of cash. Furthermore, we find that the influence of investing in financial institutions is more evident for NSOEs than SOEs in China.
Executive Corruption, Contagion Effect, and Investor Protection — Empirical Evidence from the Bai Peizhong Case
Authors: Chen Dong , Liu Qiliang , Luo Le , Yao Yiwei 
Published: October 2014

Abstract
By studying a recent executive corruption case in China (the Bai Peizhong case), which was initially exposed by a theft, later blocked by the local security department, and finally spread through the Internet, this paper first examines the contagion effect of executive corruption and its determinants and transmission mechanism. We find that (1) in response to the news, the stock prices of the two listed companies involved declined over the event window and the negative effect spilt over to their peer companies in the same industries; (2) the above contagion effect was more pronounced in the state-owned peers but was attenuated by the employment of an outside Big Four auditor; (3) the stock prices of the two involved companies declined and their peers’ behaviour was inhibited by the dismissal of Bai Peizhong; (4) the above market reaction was a result of investors’ expectation of the existence of large non-pecuniary compensation in the involved companies and industries; and (5) the contagion effect was not influenced by earnings management or the financial restatement of the peer firms.
Acoustic wavefield and Mach wave radiation of flashing arcs in strombolian explosion measured by image luminance
Authors: Genco Riccardo , Ripepe Maurizio , Marchetti Emanuele , Bonadonna Costanza , Biass Sebastien 
Published: October 2014

AbstractExplosive activity often generates visible flashing arcs in the volcanic plume considered as the evidence of the shock‐front propagation induced by supersonic dynamics. High‐speed image processing is used to visualize the pressure wavefield associated with flashing arcs observed in strombolian explosions. Image luminance is converted in virtual acoustic signal compatible with the signal recorded by pressure transducer. Luminance variations are moving with a spherical front at a 344.7 m/s velocity. Flashing arcs travel at the sound speed already 14 m above the vent and are not necessarily the evidence of a supersonic explosive dynamics. However, seconds later, the velocity of small fragments increases, and the spherical acousto‐luminance wavefront becomes planar recalling the Mach wave radiation generated by large scale turbulence in high‐speed jet. This planar wavefront forms a Mach angle of 55° with the explosive jet axis, suggesting an explosive dynamics moving at Mo = 1.22 Mach number.
Synthesis and Characterization of Cross‐linked Polyethylene Glycol/Carboxymethyl Chitosan Hydrogels
Authors: MOHAMED RIHAM R. , SEOUDI RANIA S. , SABAA MAGDY W. 
Published: October 2014

ABSTRACTCross‐linked hydrogels of polyethylene glycol (PEG) and carboxymethyl chitosan (CMCh) were synthesized using a blending technique. Several analysis tools were used to characterize the physical and thermal properties of CMCh/PEG hydrogels, namely, Fourier transform infrared, scanning electron microscope, X‐ray diffraction, and thermogravimetric analysis. Some applications were carried out for the prepared cross‐linked hydrogels; swelling behavior of the CMCh/PEG hydrogels was studied in different buffered solutions and different salt solutions. Metal ions uptake was studied for CMCh/PEG hydrogels. The biological activity of CMCh/PEG towards Escherichia coli has been examined in this study.
Are offending trajectories identified in population sample studies relevant for treatment settings? A comparison of long‐term offending trajectories in individuals treated for substance abuse in adolescence, to a matched general population sample
Authors: Molero Yasmina , Larsson Agne , Tengström Anders , Eklund Jenny 
Published: October 2014

AbstractBackgroundMost studies on offending heterogeneity have been conducted with general population samples. It is not clear to what extent these can inform such outcomes for individuals with substance use disorders specifically.AimsThe aim of this study is to compare the offending trajectories of individuals treated for substance use disorders in adolescence with a matched general population sample, and to test for gender differences in this respect.MethodGrowth mixture models were applied to identify offending trajectories from age 15 to 33 of 1568 individuals treated for substance use disorders in adolescence, and in a matched population‐based sample of 1500 individuals.ResultsSeveral parallel trajectories for men and for women were identified in both samples. The substance misuse treatment sample, however, had higher levels of offending, larger offender classes, longer careers and two additional, distinct trajectories. Although there were similarities between the men and women, the men were more heterogeneous offenders. There were two distinct offending trajectories among male substance misusers—decreasing high level and decreasing low level offending.ConclusionsDifferences between substance using and general population samples indicate that results from the latter could underestimate the severity, heterogeneity, and persistence of offending trajectories if merely generalised to individuals with substance use disorders. Our results also indicated that population‐based samples might be underpowered for detecting female offending heterogeneity. Copyright © 2014 John Wiley & Sons, Ltd.