bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broadband inductorless vector modulator IC for localisation and communication systems
Authors: Wagner J. , Joram N. , Wolf R. , Ellinger F. 
Published: April 2015

An inductorless vector modulator‐based radio frequency (RF) weighting circuit working from 1 to 10 GHz is presented. Amplitude and phase interdependencies were strongly reduced employing optimised attenuators. The vector modulator features a 360° phase and more than 40 dB amplitude control range with a root mean square phase and amplitude error of only 6° and 0.16 dB, respectively. These features make it a suitable candidate for communication and localisation diversity frontends in the 2.4 and the 5.9 GHz industrial, scientific and medical (ISM) bands. The circuit was fabricated in a 180 nm BiCMOS technology and contains an inter‐integrated circuit (I2C) control interface and digital‐to‐analogue converters. It consumes 87 mW and requires an area of only ≃0.2 mm2.
Characterisation of DNA biopolymer‐based UV photodetector fabricated by inkjet printing
Authors: Lombardi J.P. , Aga R.S. , Heckman E.M. , Bartsch C.M. 
Published: April 2015

The performance of a printable, ultraviolet (UV) photoconducting biopolymer is investigated for UV photodetectors of varying layer thicknesses. The biopolymer is formed from deoxyribonucleic acid (DNA) with the addition of the Clevios P formulation of poly(3,4‐ethylenedioxythiophene)‐poly(styrenesulphonate) (PEDOT:PSS) and hexadecyltrimethyl‐ammonium chloride (CTMA); it is then combined with phenyl‐C61‐butyric acid methyl (PCBM) to make a printable, UV photoconducting material. The highest measured responsivity of the photodetectors is 1.2 mA/W at 20 V bias using a 260 nm source.
Cervical Ligamentum Flavum Hematoma: A Case Report
Authors: Haghnegahdar Ali , Sedighi Mahsa , Rahmanian Abdolkarim , Baghban Fahim 
Published: April 2015

Study Design Case report. Objective To report the first case of ligamentum flavum hematoma after cervical spine instrumentation 11 years after the index surgery. Methods After performing bilateral C3 and C4 laminectomy, we observed a dark greenish discoloration over the ligamentum flavum, which was opened. We evacuated 15 mL of subacute hematoma. Results The first ligamentum flavum hematoma of the cervical spine that occurred after spinal instrumentation with sublaminar hooks. Conclusion Ligamentum flavum hematoma might happen even after a long delay (in our case, 11 years) from spinal instrumentation (sublaminar hooks). In symptomatic patients, evacuation is the treatment of choice. In cases of instrument adhesion to the surrounding intracanal tissues, removal should be done meticulously after performing a complete release.
Architecture and migration of an epithelium on a cylindrical wire
Authors: Yevick Hannah G. , Duclos Guillaume , Bonnet Isabelle , Silberzan Pascal 
Published: April 2015

SignificanceCell sheets often organize in tubular structures, for example, in the kidney. Also, cells from epithelial tumors are known to wrap around vessels or muscle fibers as they migrate collectively. By plating cells on thin glass wires, we mimic these physiological conditions in vitro and show that high curvature favors cell detachment at the front edge. This switch from collective to individual migration may reproduce features often observed in cancer invasion. High curvature also induces a circumferential organization of the actin cytoskeleton reminiscent of in vivo embryonic morphogenesis situations where tissues develop on a cylindrical template. Finally, monolayer migration is halted at submicron radii, and the tissue reconfigures into hollow cysts at its leading tip.
Ultrafast desorption of colloidal particles from fluid interfaces
Authors: Poulichet Vincent , Garbin Valeria 
Published: April 2015

Significance
Solid particles can replace surfactants to stabilize emulsions and foams. The attachment of particles onto drops and bubbles is typically considered to be irreversible because of a large energy barrier for particle detachment––millions of times the thermal energy for microparticles. Here we demonstrate a method to promote the detachment of microparticles from bubbles using ultrasound. We identified conditions for complete particle removal and recovery in under a millisecond. Our method is programmable in time, and does not require any physicochemical modification of the fluids or the interface. This work addresses the emerging need for methods to recover interfacial particles from emulsions and foams in applications ranging from controlled release to interfacial catalysis and gas storage.
kSNP3.0: SNP detection and phylogenetic analysis of genomes without genome alignment or reference genome
Authors: Gardner Shea N , Slezak Tom , Hall Barry G. 
Published: April 2015

Abstract
Summary:We announce the release of kSNP3.0, a program for SNP identification and phylogenetic analysis without genome alignment or the requirement for reference genomes. kSNP3.0 is a significantly improved version of kSNP v2.
Availability and implementation: kSNP3.0 is implemented as a package of stand-alone executables for Linux and Mac OS X under the open-source BSD license. The executable packages, source code and a full User Guide are freely available at https://sourceforge.net/projects/ksnp/files/
Contact: barryghall@gmail.com
Fine-tuning of T-cell development by the CD3γ di-leucine-based TCR-sorting motif
Authors: Lauritsen Jens Peter H. , Boding Lasse , Buus Terkild B. , Kongsbak Martin , Levring Trine B. , Rode Anna K. O. , Bonefeld Charlotte Menné , Geisler Carsten 
Published: April 2015

AbstractThe CD3γ di-leucine-based (diL) receptor-sorting motif plays a central role in TCR down-regulation and in clonal expansion of virus-specific T cells. However, the role of the CD3γ diL motif in T-cell development is not known. In this study, we show that protein kinase C-induced TCR down-regulation is abolished in thymocytes from CD3γLLAA mice with a mutated CD3γ diL motif, and that CD3γLLAA mice have reduced numbers of thymocytes compared with aged-matched wild-type mice. We found that early thymocyte development at the β-selection checkpoint is impaired resulting in reduced numbers of double negative (DN) 4 cells in CD3γLLAA mice. This was not caused by reduced proliferation but most probably by increased down-regulation of the antiapoptotic molecule Bcl-2 causing enhanced apoptosis during the transition from the DN3 to the DN4 stage. In contrast, proliferation of immature CD8 single positive (ISP) thymocytes was increased resulting in normal numbers of ISP in CD3γLLAA mice. Despite the normal numbers of ISP, CD3γLLAA mice had reduced numbers of double positive and SP thymocytes indicating that the CD3γ diL motif also affected later stages of T-cell development. In accordance, we found that positive and negative selection, differentiation toward CD4 and CD8 SP T cells and the development of nonconventional T cells were affected in CD3γLLAA mice. In conclusion, our study identifies an important role of the CD3γ diL motif in T-cell development most probably mediated by its fine-tuning of pre-TCR and TCR expression, down-regulation and signaling.
A novel alanine to serine substitution mutation in SoxS induces overexpression of efflux pumps and contributes to multidrug resistance in clinical Escherichia coli isolates
Authors: Aly Sherine A. , Boothe Dawn M. , Suh Sang-Jin 
Published: April 2015

Abstract

Objectives
The purpose of this study was to describe a putative role for a novel soxS mutation in contributing to multiple-antibiotic resistance in canine fluoroquinolone-associated MDR (FQ-MDR) Escherichia coli. This soxS mutation was discovered in canine faecal E. coli isolates during a study investigating the effect of oral fluoroquinolone administration on faecal E. coli in healthy dogs.

Methods
We determined via quantitative real-time RT–PCR that both soxS and acrB were overexpressed in the clinical soxS Ala-12→Ser (soxSA12S) mutants and this may account for their FQ-MDR phenotype. We validated the FQ-MDR phenotype of the clinical isolates by reconstructing the WT and the soxSA12S mutation in the E. coli soxS null mutant JW4023 (soxS::kn) via allelic exchange.

Results
The JW4023 soxSA12S derivative showed an increase in MICs of ciprofloxacin, enrofloxacin and chloramphenicol compared with the JW4023 derivative in which the WT soxS had been restored. The soxS and acrB genes were overexpressed in the JW4023 soxSA12S mutant compared with JW4023 with WT soxS. A similar overexpression of efflux pump genes and an increase in antibiotic resistance were observed upon stimulation with paraquat to resemble the phenotype of the clinical soxSA12S isolates.

Conclusions
Our data suggest that the soxSA12S substitution mutation is selected in clinical isolates when dogs are exposed to a fluoroquinolone and that this mutation contributes to the FQ-MDR phenotype of E. coli isolates.
Characterization of MDR and XDR Streptococcus pneumoniae in Canada, 2007–13
Authors: Golden Alyssa R. , Rosenthal Margot , Fultz Ben , Nichol Kimberly A. , Adam Heather J. , Gilmour Matthew W. , Baxter Melanie R. , Hoban Daryl J. , Karlowsky James A. , Zhanel George G. 
Published: April 2015

Abstract

Objectives
The goal of this study was to characterize Streptococcus pneumoniae demonstrating MDR (resistant to three or more antimicrobial classes) or XDR (resistant to five or more classes) phenotypes, collected from Canada during the CANWARD 2007–13 study.

Methods
From 2007 to 2013 inclusive, S. pneumoniae isolates were collected as a part of the CANWARD surveillance study. MDR and XDR isolates were subjected to PFGE, MLST, molecular detection of pneumococcal pili and macrolide resistance determinants mef(A/E) and erm(B), sequencing of PBPs 1A, 2B and 2X and comparison with Pneumococcal Molecular Epidemiology Network (PMEN) clones.

Results
Of 2129 S. pneumoniae isolates collected during the CANWARD 2007–13 study, 61 (2.9%) were found to be MDR. Of these MDR isolates, 43 (70.5%) were XDR. The most common serotypes for both MDR and XDR S. pneumoniae were 19A and 19F. Twenty-nine of 61 isolates (48%) demonstrated resistance to clarithromycin, clindamycin, doxycycline, penicillin and trimethoprim/sulfamethoxazole. All isolates possessed at least one macrolide resistance determinant and mutations in PBPs 1A, 2B and 2X. The most common clone was piliated, XDR ST320, an internationally circulating double-locus variant of Taiwan19F-14 (ST236).

Conclusions
Though the rate of MDR S. pneumoniae has remained relatively stable since 2007, XDR strains have emerged in Canada. These strains are virulent, possess resistance determinants and are related to international clones.
Informatics to support the IOM social and behavioral domains and measures
Authors: Hripcsak George , Forrest Christopher B , Brennan Patricia Flatley , Stead William W 
Published: April 2015

Abstract
Consistent collection and use of social and behavioral determinants of health can improve clinical care, prevention and general health, patient satisfaction, research, and public health. A recent Institute of Medicine committee defined a panel of 11 domains and 12 measures to be included in electronic health records. Incorporating the panel into practice creates a number of informatics research opportunities as well as challenges. The informatics issues revolve around standardization, efficient collection and review, decision support, and support for research. The informatics community can aid the effort by simultaneously optimizing the collection of the selected measures while also partnering with social science researchers to develop and validate new sources of information about social and behavioral determinants of health.
Brands on a wet, black bough: marketing the masterworks of modernism
Authors: Brown Stephen 
Published: April 2015

Purpose– In a world where commerce and culture are still somewhat estranged, the purpose of this paper is to show that high culture’s supreme exponents were commercially minded masters of marketing.Design/methodology/approach– Historically situated, the paper adopts a biographical approach to the making of modernism’s literary masterworks. It focuses on Ezra Pound, T.S. Eliot and James Joyce, who were responsible for the modernist classics,UlyssesandThe Waste Land.Findings– The analysis identifies five fundamental marketing principles that appear paradoxical from a traditional, customer-centric standpoint, yet are in accord with latter-day, post-Kotlerite conceptualisations. The marketing of modernism did not rely on “modern” marketing.Practical implications– If, at the height of the anti-bourgeois modernist movement, the “great divide” between elite and popular culture was bridged by marketing, there is no reason why contemporary culture and commerce cannot collaborate, co-operate, co-exist, coalesce.Originality/value– The paper complements prior studies of “painterpreneurs”, by drawing attention to the marketing of literary masterworks.
Production and marketing of art in China
Authors: Dholakia Ruby Roy , Duan Jingyi , Dholakia Nikhilesh 
Published: April 2015

Purpose
– The purpose of this paper is to explore how art production and marketing in China is attempting to move up the value chain as increasing number of Chinese replica-selling galleries seek to break free from the image of Chinese art towns as skilled but imitative centres of art production.

Design/methodology/approach
– In-depth interviews were conducted among seven gallery owners in Wushipu art village over three weeks to discover how art production in China has evolved and to chart its future growth.

Findings
– In the Chinese setting with its distinctive cultural patterns, tensions between the emergent national pride in original art and the facile and commercial moneymaking potential of simply selling industrially produced art are revealed.

Practical implications
– The changing dynamics of arts markets in China provide marketers and researchers a glimpse into a parallel trend: the gradual but rising shift to innovation, originality and luxury occurring in the China-based manufacturing centres of material goods.

Social implications
– The attempts to break from the imitative mass production of art and strike a balance between creating and meeting the art needs of the Chinese consumer indicate how domestic market priorities and economic growth are likely to serve as the new fuel for contemporary China’s socioeconomic development.

Originality/value
– Via an interpretive look at contemporary Chinese modes of arts production and marketing, the paper revisits the antagonism between the creation of original art and the production of industrial art in a context not well-known in the west, the massive art production centres of China.
Impact of pricing and outsourcing models on Indian information technology service outsourcing
Authors: Jain Daisy Mathur , Khurana Reema 
Published: April 2015

Purpose– The information technology (IT) industry has grown owing to the increase in IT outsourcing prompted by the need for cost reductions in organizations. The IT industry contracts are based on pricing models, which establish the terms and conditions of payment to be made to vendors by clients. The pricing models followed in the industry are mainly Fixed Time Fixed Price (FTFP) and Time and Material (TnM) and the remaining are mostly variations of these. Using the information collected from vendors, the purpose of this paper is to draw a comparison between these pricing models to see which one is more acceptable to vendors along with researching on the reasons behind that. The outsourcing engagement is also based on a set of processes to be used during the contract time and that is known as the Outsourcing Model (OM) being used. This research also derives how pricing models, OMs and Client Vendor Relationship (CVR) being developed are related.Design/methodology/approach– Hypothesis have been formulated on the basis of the literature survey conducted by the authors, subsequently questionnaire was formulated and data were collected from – a total of 500 people were targeted, out of which 70 people responded. Out of these 70 only 50 were usable responses. The respondents were at the manager and above level in different organizations classified on the basis of number of employees. Statistical tests were conducted on these data to check the reliability, prove the hypothesis and establish the mediation and moderation relationships between the pricing model, OM and CVR.Findings– The following paper has established through statistical analysis which pricing model is more befitting to the IT service outsourcing industry and has also demonstrated the moderation and mediation relationship between pricing model, OM and CVR variables.Research limitations/implications– The major reserach limitation is that it is for only IT vendors in Indian geography. The research can be extended to different businesses and geographies.Practical implications– The paper has practical implications for the IT service outsourcing industry in India and for their clients to understand the comparison between the pricing models and to study the impact of pricing and OMs on the CVRs.Originality/value– The research presented is original as no similar work has been found to be published in the journals so far specifically in the Indian context.
Benchmarking supply chains by analyzing technology transfer critical barriers using AHP approach
Authors: Kumar Sanjay , Luthra Sunil , Haleem Abid 
Published: April 2015

Purpose
– Technology transfer becoming an important area especially in developing and less developed countries. The purpose of this paper is to address issue of supply chains’ benchmarking based upon their capability to mange technology transfer critical barriers mitigation efforts toward making technology transfer process implementation successful.

Design/methodology/approach
– The present paper is based on two research stages. Initially, extensive literature review has been made to identify critical barriers. In total, 20 technology transfer critical barriers have been identified from literature review and categorized in to six criteria. In second stage, analytics hierarchy process has been utilized to rank the critical barriers of technology transfer in supply chain and provide a benchmarking framework.

Findings
– Political barriers (PB) have been analyzed most significant criteria of critical barriers to technology transfer followed by socio-cultural barriers (SO) and economic barriers (EB). “Political instability,” “Difficulty in transfer and diffusion,” “Too expensive,” “Inappropriate/incompetent technology and resource wastage in technologies imported,” “Inactive role of SC members and resistance to change” and “Management attitude” have been found most hindering barrier in their respective category/criterion of technology transfer barriers.

Research limitations/implications
– Scope of the present study has been limited to propose framework to benchmark supply chains by analyzing 20 critical barriers of technology transfer grouped in to six dimensions using analytical hierarchy approach based on “ratings provided by experts,” which may be biased.

Practical implications
– Benchmarking process has been proposed to calculate value of total of overall weights to a particular supply chain named as “Technology Transfer Barriers Mitigation Index (TTBMI)” useful to present capability of supply chains to manage technology transfer barriers by a single numeric value. From “provider” developed county’s view point, present benchmarking framework may be further applied to compare developing countries’ ability to absorb and diffuse new technology.

Originality/value
– Benchmarking procedure has been dealt with using well-established methodology- analytical hierarchy process toward providing single numeric value index (TTBMI) indicating ability of supply chains to manage/mitigate technology transfer barriers.
Developing a novel data envelopment analysis model to determine prospective benchmarks of green supply chain in the presence of dual-role factor
Authors: Shabani Amir , Farzipoor Saen Reza 
Published: April 2015

Purpose
– The purpose of this paper is to develop a model based on data envelopment analysis (DEA) and program evaluation and review technique/critical path method (PERT/CPM) for determining prospective benchmarks.

Design/methodology/approach
– The idea of determining prospective benchmark is needed for developing a model for future planning where inputs and outputs of systems are influenced by external factors such as economic conditions, demographic changes, and other socio-economic factors. In this paper, the PERT/CPM method estimates prospective inputs and outputs. On the other hand, in particular systems some measures play the role of both input and output. Such factors in DEA literature are called dual-role factors. This paper integrates PERT/CPM technique and the DEA.

Findings
– The results of the proposed model depict that a present benchmark may not be a benchmark in future. A numerical example validates the proposed model.

Originality/value
– This paper, for the first time, applies the PERT/CPM technique to incorporate the ideas for identifying prospective benchmarks. Moreover, the proposed model is an alternative solution for classifying inputs and outputs in DEA. Also, the proposed model is utilized in benchmarking green supply chain management.
Fraud in overseas aid and the challenge of measurement
Authors: Button Mark , Lewis Chris , Shepherd David , Brooks Graham 
Published: April 2015

Purpose– The purpose of this paper is to explore the challenges of measuring fraud in overseas aid.Design/methodology/approach– The research is based on 21 semi-structured interviews with key persons working in the delivery of aid in both the public and voluntary sectors. It uses the UK Department for International Development as a case study to applying more accurate measures of fraud.Findings– This paper shows there are significant challenges to using fraud loss measurement to gauge fraud in overseas aid. However, it argues that, along with other types of measures, it could be used in areas of expenditure in overseas governments and charities to measure aid. Given the high risk of such aid to fraud, it argues helping to develop capacity to reduce aid, of which measuring the size of the problem is an important part; this could be considered as aid in its own right.Research limitations/implications– The researchers were not able to visit high-risk countries for fraud to examine in the local context views on the challenges of measuring fraud.Practical implications– The paper offers insights on the challenges to accurately measuring fraud in an overseas context, which will be useful to policy-makers in this context.Social implications– Given the importance of as much aid as possible reaching recipients, it offers an important contribution to helping to reduce losses in this important area.Originality/value– There has been very little consideration of how to measure fraud in the overseas aid context, with most effort aimed at corruption, which poses some of the same challenges, as well as some very different challenges.