bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peer Review at the Health Information and Libraries Journal
Authors: Grant Maria J. 
Published: November 2014

AbstractAt its best, peer review can mean receiving constructive feedback to help you make the most of your writing. At the Health Information and Libraries Journal, we strive to make the peer review a positive process for both authors and referees. We adopt a process of double‐blind peer review. To receive two reviews in a timely manner, three referees are initially invited for each article submitted. The referees are asked to submit their review noting errors, areas of ambiguity or clarification required before the editor and editorial team consider the manuscript ready for publication. As with most journals, it's unlikely that your writing will be accepted in its original form; a typical outcome will be for a recommendation for major or minor revisions. This is good! It means the editorial team has seen something of likely interest to their readership and wants to help you develop it to a publishable standard. There can be a surprising amount of development and change in a manuscript from original submission through to publication. While you may be experienced in your field, you may not have much experience of writing for publication. As a referee, you get an intriguing insight into the shape of manuscripts in their original form.
Gene and protein expression of oestrogen‐β and progesterone receptors in facial melasma and adjacent healthy skin in women
Authors: Tamega A. de A. , Miot H. A. , Moço N. P. , Silva M. G. , Marques M. E. A. , Miot L. D. B. 
Published: November 2014

SynopsisObjectiveCompare gene and protein expression for oestrogen receptor‐β (ER‐β) and progesterone receptor (PR) in facial melasma and adjacent healthy skin.MethodsA cross‐sectional study including 42 women with facial melasma, conducted at the Dermatology Service of Botucatu Medical School of São Paulo State University, Brazil. Biopsies of the melasma skin were performed, together with healthy surrounding skin. The gene expression (real‐time PCR) of the hormone receptors in the tissue was evaluated. Subsequently, skin fragments were immunostained for nuclear ER‐β and PR, evaluated according to their HSCORE (epidermis) and percentage of staining per microscopic field (dermis).ResultsMessenger RNA tissue expression for ER‐β and PR showed no difference between melasma‐affected skin fragments and the healthy perilesional areas (P > 0.2). Median nuclear epithelial expression for ER‐β and PR was higher in lesioned skin (HSCORE 157 and 58) than in the healthy perilesional skin (HSCORE 97 and 19; P < 0.01), with no difference in dermal immunostaining. Nuclear histological expression for ER‐β was associated to sun‐induced melasma and negative familiar background; PR expression was associated to sun‐induced melasma and darker phototypes.ConclusionNo difference was observed in gene expression for oestrogen‐β and progesterone receptors in melasma‐affected skin compared with adjacent healthy skin. However, the higher protein expression of these receptors in melasma‐affected epithelia suggests hormonal participation in the pathogenesis of this disease.
Improvement of the facial evenness of leave‐on skincare products by a modified application method in Chinese women
Authors: Zou Y. , Wang X. , Fan G. 
Published: November 2014

SynopsisObjectiveTo understand the habits of Chinese women applying leave‐on skincare products (LOSCP) and to improve female facial evenness of anti‐ageing cosmetics through modifying facial skincare smear ways.MethodsA questionnaire on the method of applying LOSCP was distributed to 60 women with habit of using LOSCP. Their facial images before and after applying LOSCP were taken, and their positioning and grey value were used to analyse the effects of different applying methods on the uniformity of facial LOSCP.ResultsLOSCP including anti‐ageing cosmetics have been widely used among Chinese women for a long time. However, some women do not concern how to properly apply LOSCP. In our survey, the main focal points of the face are forehead, malar region, cheek, mouth corners and chin when they looking into the mirror, and mouth corners and inner canthus are often overlooked when applying cosmetic products. The image analysis found that after applying the LOSCP, the greyscale of the forehead, glabella, malar region, upper lip region and jaw changed significantly whereas that of canthus, mouth corners and lateral cheek region was not significantly different. Applying an improved smear method (11‐point method)could significantly increase the grey values of various facial areas.ConclusionThe way of Chinese women applying LOSCP may result in facial unevenness of skin products. By improving facial skincare smear method, one can make the products even in all facial areas, thereby ensuring the efficacy of anti‐ageing cosmetics. Thus, further improvement and education regarding skincare is required.
Processing of Porous SiC by Aluminum‐Derived Binders and Sacrificial Porogen Leaching Method
Authors: Resmi Viswanadhan Girija , Deepa Jayaprakash Prasanna , Lakshmi Vijaya , Rajan Thazhavilai Ponnu Devaraj , Pavithran Chorappan , Pai Bellembettu Chandrasekhara 
Published: November 2014

Porous SiC was successfully fabricated by a facile and energy efficient sacrificial porogen leaching method using in situ synthesized aluminum‐based binders by reaction bonding at low sintering temperatures of 600–1000°C. Porous SiC ceramics with porosity in the range of 30–58% and compressive strength of 1–33 MPa were obtained. Interconnected bimodal pores were produced by both stacking of SiC particles and leach out of salt. During sintering, the aluminum binder experienced metal to ceramic transformations forming various alumina polymorphs (γ, δ, θ and α‐Al2O3). The porogen content and sintering temperatures significantly influence the properties of porous SiC.
A novel intronic splice site deletion of the IL‐2 receptor common gamma chain results in expression of a dysfunctional protein and T‐cell‐positive X‐linked Severe combined immunodeficiency
Authors: Gray P. E. A. , Logan G. J. , Alexander I. E. , Poulton S. , Roscioli T. , Ziegler J. 
Published: November 2014

SummaryX‐linked severe combined immunodeficiency is caused by mutations in the IL‐2 receptor common gamma chain and classically presents in the first 6 months of life with predisposition to bacterial, viral and fungal infections. In most instances, affected individuals are lymphopenic with near complete absence of T cells and NK cells. We report a boy who presented at 12 months of age with Pneumocystis jiroveci pneumonia and a family history consistent with X‐linked recessive inheritance. He had a normal lymphocyte count including the presence of T cells and a broad T‐cell‐receptor diversity, as well as normal surface expression of the common gamma chain (CD132) protein. He however had profound hypogammaglobulinaemia, and IL‐2‐induced STAT5 phosphorylation was absent. Sequencing of IL‐2RG demonstrated a 12‐base pair intronic deletion close to the canonical splice site of exon 5, which resulted in a variety of truncated IL2RG mRNA species. A review of the literature identified 4 other patients with T‐cell‐positive X‐SCID, with the current patient being the first associated with an mRNA splicing defect. This case raises the question of how a dysfunctional protein incapable of mediating STAT5 phosphorylation might nonetheless support T‐cell development. Possible explanations are that STAT5‐mediated signal transduction may be less relevant to IL7‐receptor‐mediated T‐cell development than are other IL7R‐induced intracellular transduction pathways or that a low level of STAT5 phosphorylation, undetectable in the laboratory, may be sufficient to support some T‐cell development.
RHX Dating of Archeological Ceramics Via a New Method to Determine Effective Lifetime Temperature
Authors: Moinester Murray , Piasetzky Eli , Braverman Michael 
Published: November 2014

Determining the absolute chronology of ceramic artifacts has significant implications for archeological and historical research. Wilson, Hall et al. recently suggested a new technique for direct absolute dating of archeological ceramics based on a moisture‐induced chemical reaction, called rehydroxylation (RHX) dating. RHX dating proceeds by measuring the mass of chemically combined water in the ceramics in the form of OH hydroxyls, and the mass gain rate at the Effective Lifetime Temperature (ELT) that the ceramics experienced over its lifetime. To date, ELT determinations have been based on estimates of the ceramic's lifetime temperature history; taking into account weather and climate data and the depth at which the artifact was found. The uncertainty in determining the ELT can be a major component of the overall dating uncertainty. Here, we propose an alternative method which relies minimally on weather and climate data, and provides more precise determinations of the ELT and the ceramic age. The proposed method (SAS: Same Age Samples) involves a minimum of four measurements of the RHX mass gain rate constant for two ceramic samples of the same age at two temperatures. We show via simulations that the proposed SAS method can determine the ELT with a precision of 0.2 K which is comparable to the best ELT determination based on lifetime temperature history, and also comparable to available microbalance temperature resolutions of around 0.1 K. The corresponding percent age error is then 1.4%, or 43 yr for a 3000‐yr‐old ceramic. The proposed SAS method should be tested with ceramic samples of different ages, whose ELT are well‐known.
Thermally Stable BaTiO3‐Bi(Mg2/3Nb1/3)O3 Solid Solution with High Relative Permittivity in a Broad Temperature Usage Range
Authors: Chen Xiuli , Chen Jie , Ma Dandan , Fang Liang , Zhou Huanfu 
Published: November 2014

A combined X‐ray diffraction (XRD), Raman spectra, X‐ray photoelectron spectroscopy, Scanning electron microscopy, and dielectric characterization of (1–x)BaTiO3−xBi(Mg2/3Nb1/3)O3 ceramic system were investigated for compositions of 0 ≤ x ≤ 0.2. Single‐phase perovskite‐type XRD patterns were observed for all compositions. A systematically structural change from tetragonal to pseudocubic symmetry occurred at 0.04 < x < 0.06, which agrees well with the analysis of Raman spectra. Dielectric measurements indicated that the crossover from a classic ferroelectric to relaxor ferroelectric occurred at x ≥ 0.04. Compared with other compositions, the temperature independence of relative permittivity at T > Tm significantly ameliorated at x = 0.1: near‐stable temperature coefficient of higher relative permittivity (~6800 ± 15%) and the corresponding loss tanδ ≤ 0.09 over a more broader temperature range of 25°C–240°C (1 kHz), which indicates that this ceramic is a promising dielectric material for elevated temperature dielectrics.
Investigation on Tunable Performance of BMN/BST Multilayer and BMN–BST Composite Thin Films
Authors: Yu Shihui , Li Lingxia , Zhang Weifeng , Xu Dan , Dong Helei 
Published: November 2014

The BMN/BST multilayer and BMN–BST composite thin films have been fabricated by pulsed laser deposition on Au/TiOx/SiO2/Si substrate. The multilayer thin films comprising one, two, and four periodic compositional Bi1.5MgNb1.5O7/Ba0.6Sr0.4TiO3 (BMN/BST) layers (PCBLs) have been elaborated with the final same thickness. The four PCBLs show the largest dielectric constant of ~168 and tunability of 40.6% at a maximum applied bias field of 0.67 MV/cm and the lowest loss tangent of ~0.006, whereas the figure of merit (FOM) is 72. The BMN–BST composite thin films exhibit medium dielectric constant of ~238, low loss tangent of ~0.0053, and superior tunable dielectric properties at room temperature. Calculations of tunability and FOM display a maximum value of 49.3% at 670 kV/cm and ~88, respectively.
Individuals’ Trading Prior to Earnings Announcements
Authors: Tsai Shih‐Chuan 
Published: November 2014

AbstractThis paper investigates the relationship between individuals’ net trading and stock price movements before and after annual earnings announcements for the Taiwan Stock Exchange. We conduct an event study on the effects of pre‐event individual trade imbalances on pre‐ and post‐announcement abnormal returns. With a unique and comprehensive dataset, we accurately classify executed orders by aggressiveness of order price. The evidence indicates that while individuals, as a group, are not informed about impending earnings announcements, individuals who place aggressive orders are informed as their net trading coincides with contemporaneous and future stock returns. Aggressive individuals lose their edge during the financial crisis. More importantly, the advantage (disadvantage) for individuals who adopt aggressive (passive) orders weakens when foreign institutions own concentrated equity in firms. We also find that net individual trading contains information about abnormal returns that either past returns or volume does not subsume. Controlling for past returns, trading volume and volatility, or using an alternative measure of net individual trading does not change our conclusions.
The Effect of Numeracy Level on Completeness of Home Blood Pressure Monitoring
Authors: Rao Vishal N. , Sheridan Stacey L. , Tuttle Laura A. , Lin Feng‐Chang , Shimbo Daichi , Diaz Keith M. , Hinderliter Alan L. , Viera Anthony J. 
Published: November 2014

Home blood pressure monitoring (HBPM) readings predict the increased risks of cardiovascular events and end‐organ damage independent of office blood pressure (BP). Numeracy (the ability to handle numbers) may limit the feasibility of patients' performing HBPM. The authors analyzed data from 409 adults recruited from 12 North Carolina primary care clinics who completed a three‐item numeracy assessment, the Rapid Estimate of Adult Literacy in Medicine–Short Form health literacy assessment, and HBPM over 2 weeks. Among the 409 participants, 73% were college graduates and 69% had adequate numeracy. Completion of HBPM was greater among those with adequate numeracy (96.2% vs 93.7%; P=.009) and did not correlate with health literacy scores. More participants with adequate numeracy reported completion of ≥85% of readings than those with low numeracy (95% vs 88%; P=.018). Adequate numeracy, but not high literacy, is associated with more complete HBPM reporting. Whether higher numeracy is associated with more accurate self‐reported readings is an area of future research.
Ambulatory vs Office Blood Pressure Monitoring in Renal Transplant Recipients
Authors: Ahmed Jafar , Ozorio Valerie , Farrant Maritza , Van Der Merwe Walter 
Published: November 2014

Hypertension is common following renal transplantation and has adverse effects on cardiovascular and graft health. Ambulatory blood pressure monitoring (ABPM) is better at overall blood pressure (BP) assessment and is necessary to diagnose nocturnal hypertension, which is also implicated in poor outcomes. The authors performed a retrospective analysis of 98 renal transplant recipients (RTRs) and compared officeBPand ambulatoryBPrecordings.ABPMrevealed discordance between officeBPand ambulatoryBPin 61% of patients, with 3% caused by white‐coat and 58% caused by masked hypertension (of which 33% were caused by isolated nocturnal hypertension). Overall, mean systolicBPwas 3.6 mm Hg (0.5–6.5) and diastolicBPwas 7.5 mm Hg (5.7–9.3) higher via ambulatoryBPthan officeBP. This was independent of estimated glomerular filtration rate, proteinuria, transplant time/type, and comorbidities. A total of 42% of patients had their management changed after results fromABPM.ABPMshould be routinely offered as part of hypertension management inRTRs.
Effect of Fall‐Related Concerns on Physical, Mental, and Social Function in Community‐Dwelling Older Adults: A Prospective Cohort Study
Authors: van der Meulen Erik , Zijlstra G.A. Rixt , Ambergen Ton , Kempen Gertrudis I.J.M. 
Published: November 2014

ObjectivesTo determine the effect of fall‐related concerns on physical, mental, and social function.DesignCommunity‐based prospective cohort study (secondary analysis using control group data from a randomized controlled trial).SettingTwo municipalities in the south of the Netherlands.ParticipantsCommunity‐dwelling older adults (N = 260).MeasurementsTwo groups were created using Modified Falls Efficacy Scale scores (high and low levels of fall‐related concerns). Five outcome measures representing physical, mental, and social function were included: activities of daily living (ADLs), symptoms of depression, feelings of anxiety, social participation, and social support interactions. Outcomes were measured at baseline and at 2, 8, and 14 months. Data were analyzed using analysis of covariance and mixed‐effect regression models for longitudinal data, adjusting for age, sex, living status (alone or with another person), educational level, cognitive status, self‐perceived health, and falls history at baseline.ResultsAt baseline, significantly more limitations in ADLs and social participation were found for older persons with high levels of fall‐related concerns than for those with low levels of concern. These differences persisted over 14 months of follow‐up and were consistent over time. No significant differences were found for symptoms of depression, feelings of anxiety, or social support interactions, except for feelings of anxiety at 14 months.ConclusionOlder persons with higher levels of fall‐related concerns reported up to 14 months poorer ADL and social participation for up to 14 months than those with lower levels of fall‐related concerns. From a clinical point of view, the clear relationship between fall‐related concerns and ADL dysfunction and social participation may help to target groups who are at risk of developing adverse consequences of concerns about falls.
Changes in Bone Mineral Density May Predict the Risk of Fracture Differently in Older Adults According to Fall History
Authors: Berry Sarah D. , McLean Robert R. , Hannan Marian T. , Cupples L. Adrienne , Kiel Douglas P. 
Published: November 2014

ObjectivesTo determine whether the association between change in bone mass density (BMD) over 4 years and risk of hip and nonvertebral fracture differs according to an individual's history of falls.DesignPopulation‐based cohort study.SettingFramingham, Massachusetts.ParticipantsIndividuals with two measures of BMD at the femoral neck (mean age 78.8; 310 male, 492 female).MeasurementsCox proportional hazards models were used to estimate hazard ratios (HRs) for the association between percentage change in BMD (per sex‐specific standard deviation) and risk of incident hip and nonvertebral fracture. Models were stratified based on history of falls (≥1 falls in the past year) and recurrent falls (≥2 falls) ascertained at the time of the second BMD test. Interactions were tested by including the term “fall history * change in BMD” in the models.ResultsMean change in BMD was −0.6%/year; 27.8% of participants reported falls, and 10.8% reported recurrent falls. Seventy‐six incident hip and 175 incident nonvertebral fractures occurred over a median follow‐up of 9.0 years. There was no difference in the association between change in BMD and hip fracture according to history of falls (P for interaction = .57). The HR associated with change in BMD and nonvertebral fracture was 1.31 (95% confidence interval (CI) = 1.10–1.56) in participants without a history of falls and 0.95 (95% CI 0.70–1.28) in those with a fall (interaction P = .07). Results for recurrent fallers were similar.ConclusionThe effect of BMD loss on risk of nonvertebral fracture may be greater in persons without a history of falls. It is possible that change in BMD contributes less to fracture risk when a strong risk factor for fracture, such as falls, is present.
Mild Cognitive Dysfunction Does Not Affect Diabetes Mellitus Control in Minority Elderly Adults
Authors: Palta Priya , Golden Sherita H. , Teresi Jeanne , Palmas Walter , Weinstock Ruth S. , Shea Steven , Manly Jennifer J. , Luchsinger Jose A. 
Published: November 2014

ObjectivesTo determine whether older adults with type 2 diabetes mellitus and cognitive dysfunction have poorer metabolic control of glycosylated hemoglobin, systolic blood pressure, and low‐density lipoprotein cholesterol than those without cognitive dysfunction.DesignProspective cohort study.SettingA minority cohort in New York City previously recruited for a trial of telemedicine.ParticipantsPersons aged 73.0 ± 3.0 (N = 613; 69.5% female; 82.5% Hispanic, 15.5% non‐Hispanic black).MeasurementsParticipants were classified with executive or memory dysfunction based on standardized score cutoffs (<16th percentile) for the Color Trails Test and Selective Reminding Test. Linear mixed models were used to compare repeated measures of the metabolic measures and evaluate the rates of change in individuals with and without dysfunction.ResultsOf the 613 participants, 331 (54%) had executive dysfunction, 202 (33%) had memory dysfunction, and 96 (16%) had both. Over a median of 2 years, participants with executive or memory dysfunction did not exhibit significantly poorer metabolic control than those without executive function or memory type cognitive dysfunction.ConclusionCognitive dysfunction in the mild range did not seem to affect diabetes mellitus control parameters in this multiethnic cohort of older adults with diabetes mellitus, although it cannot be excluded that cognitive impairment was overcome through assistance from formal or informal caregivers. It is possible that more‐severe cognitive dysfunction could affect control.
Trends in Kidney Transplant Outcomes in Older Adults
Authors: McAdams‐DeMarco Mara A. , James Nathan , Salter Megan L. , Walston Jeremy , Segev Dorry L. 
Published: November 2014

ObjectivesTo estimate mortality and death‐censored graft loss according to year of kidney transplant (KT) between 1990 and 2011.DesignCohort study.SettingThe Scientific Registry of Transplant Recipients (SRTR).ParticipantsKT recipients aged 65 and older at the time of transplantation (N = 30,207).MeasurementsMortality and death‐censored graft loss ascertained through center report and linkage to Social Security Death Master File and to Medicare.ResultsOlder adults currently account for 18.4% of KT recipients, up from 3.4% in 1990; similar increases were noted for deceased donor (5.4 times percentage increase) and live donor (9.1 times percentage increase) transplants. Current recipients are not only older, but also more likely to be female and African American, have lengthier pretransplant dialysis, have diabetes mellitus or hypertension, and receive marginal kidneys. Mortality for older deceased donor recipients between 2009 and 2011 was 57% lower (hazard ratio (HR) = 0.43, 95% confidence interval (CI) = 0.33–0.56, P < .001) than between 1990 and 1993; mortality for older live donor recipients was 50% lower (HR = 0.50, 95% CI = 0.36–0.68, P < .001). Death‐censored graft loss for older deceased donor recipients between 2009 and 2011 was 65% lower (HR = 0.35, 95% CI = 0.29–0.42, P < .001) than between 1990 and 1993; death‐censored graft loss for older live donor recipients was 59% lower (HR = 0.41, 95% CI = 0.24–0.70, P < .001).ConclusionDespite a major increase in number of older adults transplanted and an expanding window of transplant eligibility, mortality and graft loss have decreased substantially for this recipient population. These trends are important to understand for patient counseling and transplant referral.