bluuebunny/crossref_metadata_2025_split huggingface dataset:
Non-modal stability in sliding Couette flow
Authors: Liu R. , Liu Q. S. 
Published: August 2012

AbstractThe problem of an incompressible flow between two coaxial cylinders with radii$a$and$b$subjected to a sliding motion of the inner cylinder in the axial direction is considered. The energy stability and the non-modal stability have been investigated for both axisymmetric and non-axisymmetric disturbances. For the non-modal stability, we focus on two problems: response to external excitations and response to initial conditions. The former is studied by examining the$\epsilon $-pseudospectrum, and the latter by examining the energy growth function$G(t)$. Unlike the results of the modal analysis in which the stability of sliding Couette flow is determined by axisymmetric disturbances, the energy analysis shows that a non-axisymmetric disturbance has a critical energy Reynolds number for all radius ratios$\eta = a/ b$. The results for non-modal stability show that rather large transient growth occurs over a wide range of azimuthal wavenumber$n$and streamwise wavenumber$\ensuremath{\alpha} $, even though the Reynolds number is far below its critical value. For the problem of response to external excitations, the response is sensitive to low-frequency external excitations. For all values of the radius ratio, the maximum response is achieved by non-axisymmetric and streamwise-independent disturbances when the frequency of external forcing$\omega = 0$. For the problem of response to initial conditions, the optimal disturbance is in the form of helical streaks at low Reynolds numbers. With the increase of$\mathit{Re}$, the optimal disturbance becomes very close to straight streaks. For each$\eta $, the maximum energy growth of streamwise-independent disturbances is of the order of${\mathit{Re}}^{2} $, and the optimal time is of the order of$\mathit{Re}$. This relation is qualitatively similar to that for plane Couette flow, plane Poiseuille flow and pipe Poiseuille flow. Direct numerical simulations are applied to investigate the transition of the streamwise vortex (SV) scenario at$\mathit{Re}= 1000$and 1500 for various$\eta $. The initial disturbances are the optimal streamwise vortices predicted by the non-modal analysis. We studied the streak breakdown phase of the SV scenarios by examining the instability of streaks. Moreover, we have investigated the sustainment of the energy of disturbances in the SV scenario.
Kolmogorov laws for stratified turbulence
Authors: Augier Pierre , Galtier Sébastien , Billant Paul 
Published: August 2012

AbstractFollowing the Kolmogorov technique, an exact relation for a vector third-order moment $\mathbi{J}$ is derived for three-dimensional incompressible stably stratified turbulence under the Boussinesq approximation. In the limit of a small Brunt–Väisälä frequency, isotropy may be assumed which allows us to find a generalized $4/ 3$-law. For strong stratification, we make the ansatz that $\mathbi{J}$ is directed along axisymmetric surfaces parameterized by a scaling law relating horizontal and vertical coordinates. An integration of the exact relation under this hypothesis leads to a generalized Kolmogorov law which depends on the intensity of anisotropy parameterized by a single coefficient. By using a scaling relation between large horizontal and vertical length scales we fix this coefficient and propose a unique law.
Reynolds number effects on lipid vesicles
Authors: Salac David , Miksis Michael J. 
Published: August 2012

AbstractVesicles exposed to the human circulatory system experience a wide range of flows and Reynolds numbers. Previous investigations of vesicles in fluid flow have focused on the Stokes flow regime. In this work the influence of inertia on the dynamics of a vesicle in a shearing flow is investigated using a novel level-set computational method in two dimensions. A detailed analysis of the behaviour of a single vesicle at finite Reynolds number is presented. At low Reynolds numbers the results recover vesicle behaviour previously observed for Stokes flow. At moderate Reynolds numbers the classical tumbling behaviour of highly viscous vesicles is no longer observed. Instead, the vesicle is observed to tank-tread, with an equilibrium angle dependent on the Reynolds number and the reduced area of the vesicle. It is shown that a vesicle with an inner/outer fluid viscosity ratio as high as 200 will not tumble if the Reynolds number is as low as 10. A new damped tank-treading behaviour, where the vesicle will briefly oscillate about the equilibrium inclination angle, is also observed. This behaviour is explained by an investigation on the torque acting on a vesicle in shear flow. Scaling laws for vesicles in inertial flows have also been determined. It is observed that quantities such as vesicle tumbling period follow square-root scaling with respect to the Reynolds number. Finally, the maximum tension as a function of the Reynolds number is also determined. It is observed that, as the Reynolds number increases, the maximum tension on the vesicle membrane also increases. This could play a role in the creation of stable pores in vesicle membranes or for the premature destruction of vesicles exposed to the human circulatory system.
Thermal and viscous boundary layers in turbulent Rayleigh–Bénard convection
Authors: Scheel J. D. , Kim E. , White K. R. 
Published: August 2012

AbstractWe present the results from numerical simulations of turbulent Rayleigh–Bénard convection for an aspect ratio (diameter/height) of 1.0, Prandtl numbers of 0.4 and 0.7, and Rayleigh numbers from $1\ensuremath{\times} 1{0}^{5} $ to $1\ensuremath{\times} 1{0}^{9} $. Detailed measurements of the thermal and viscous boundary layer profiles are made and compared to experimental and theoretical (Prandtl–Blasius) results. We find that the thermal boundary layer profiles disagree by more than 10 % when scaled with the similarity variable (boundary layer thickness) and likewise disagree with the Prandtl–Blasius results. In contrast, the viscous boundary profiles collapse well and do agree (within 10 %) with the Prandtl–Blasius profile, but with worsening agreement as the Rayleigh number increases. We have also investigated the scaling of the boundary layer thicknesses with Rayleigh number, and again compare to experiments and theory. We find that the scaling laws are very robust with respect to method of analysis and they mostly agree with the Grossmann–Lohse predictions coupled with laminar boundary layer theory within our numerical uncertainty.
Intake of polyphenol-rich pomegranate pure juice influences urinary glucocorticoids, blood pressure and homeostasis model assessment of insulin resistance in human volunteers
Authors: Tsang Catherine , Smail Nacer F. , Almoosawi S. , Davidson I. , Al-Dujaili Emad A. S. 
Published: August 2012

AbstractPomegranate juice (PJ; also known as pomegreat pure juice) provides a rich and varied source of polyphenolic compounds that may offer cardioprotective, anti-atherogenic and antihypertensive effects. The aim of this study was to investigate the effect of PJ consumption on glucocorticoids levels, blood pressure (BP) and insulin resistance in volunteers at high CVD risk. Subjects (twelve males and sixteen females) participated in a randomised, placebo-controlled cross-over study (BMI: 26·77 (sd3·36) kg/m2; mean age: 50·4 (sd6·1) years). Volunteers were assessed at baseline, and at weeks 2 and 4 for anthropometry, BP and pulse wave velocity. Cortisol and cortisone levels in urine and saliva were determined by specific ELISA methods, and the cortisol/cortisone ratio was calculated. Fasting blood samples were obtained to assess plasma lipids, glucose, insulin and insulin resistance (homeostasis model assessment of insulin resistance). Volunteers consumed 500 ml of PJ or 500 ml of a placebo drink containing a similar amount of energy. Cortisol urinary output was reduced but not significant. However, cortisol/cortisone ratios in urine (P = 0·009) and saliva (P = 0·024) were significantly decreased. Systolic BP decreased from 136·4 (sd 6·3) to 128·9 (sd 5·1) mmHg (P = 0·034), and diastolic BP from 80·3 (sd 4·29) to 75·5 (sd 5·17) mmHg (P = 0·031) after 4 weeks of fruit juice consumption. Pulse wave velocity decreased from 7·5 (sd 0·86) to 7·44 (sd 0·94) m/s (P = 0·035). There was also a significant reduction in fasting plasma insulin from 9·36 (sd 5·8) to 7·53 (sd 4·12) mIU/l (P = 0·025) and of homeostasis model assessment of insulin resistance (from 2·216 (sd 1·43) to 1·82 (sd 1·12),P= 0·028). No significant changes were seen in the placebo arm of the study. These results suggest that PJ consumption can alleviate key cardiovascular risk factors in overweight and obese subjects that might be due to a reduction in both systolic and diastolic BP, possibly through the inhibition of 11β-hydroxysteroid dehydrogenase type 1 enzyme activity as evidenced by the reduction in the cortisol/cortisone ratio. The reduction in insulin resistance might have therapeutic benefits for patients with non-insulin-dependent diabetes, obesity and the metabolic syndrome.
The gut microbiome of kittens is affected by dietary protein:carbohydrate ratio and associated with blood metabolite and hormone concentrations
Authors: Hooda Seema , Vester Boler Brittany M. , Kerr Katherine R. , Dowd Scot E. , Swanson Kelly S. 
Published: August 2012

High-protein, low-carbohydrate (HPLC) diets are common in cats, but their effect on the gut microbiome has been ignored. The present study was conducted to test the effects of dietary protein:carbohydrate ratio on the gut microbiota of growing kittens. Male domestic shorthair kittens were raised by mothers fed moderate-protein, moderate-carbohydrate (MPMC; n 7) or HPLC (n 7) diets, and then weaned at 8 weeks onto the same diet. Fresh faeces were collected at 8, 12 and 16 weeks; DNA was extracted, followed by amplification of the V4–V6 region of the 16S rRNA gene using 454 pyrosequencing. A total of 384 588 sequences (average of 9374 per sample) were generated. Dual hierarchical clustering indicated distinct clustering based on the protein:carbohydrate ratio regardless of age. The protein:carbohydrate ratio affected faecal bacteria. Faecal Actinobacteria were greater (P< 0·05) and Fusobacteria were lower (P< 0·05) in MPMC-fed kittens. Faecal Clostridium, Faecalibacterium, Ruminococcus, Blautia and Eubacterium were greater (P< 0·05) in HPLC-fed kittens, while Dialister, Acidaminococcus, Bifidobacterium, Megasphaera and Mitsuokella were greater (P< 0·05) in MPMC-fed kittens. Principal component analysis of faecal bacteria and blood metabolites and hormones resulted in distinct clusters. Of particular interest was the clustering of blood TAG with faecal Clostridiaceae, Eubacteriaceae, Ruminococcaceae, Fusobacteriaceae and Lachnospiraceae; blood ghrelin with faecal Coriobacteriaceae, Bifidobacteriaceae and Veillonellaceae; and blood glucose, cholesterol and leptin with faecal Lactobacillaceae. The present results demonstrate that the protein:carbohydrate ratio affects the faecal microbiome, and highlight the associations between faecal microbes and circulating hormones and metabolites that may be important in terms of satiety and host metabolism.
The citrus flavanone naringenin suppresses CYP1B1 transactivation through antagonising xenobiotic-responsive element binding
Authors: Poon Ching Ho , Wong Tsz Yan , Wang Yanfei , Tsuchiya Yuki , Nakajima Miki , Yokoi Tsuyoshi , Leung Lai K. 
Published: August 2012

Exposure to environmental toxicants or exogenous oestrogen increases the risk of cancer. Some toxicants such as polycyclic aromatic hydrocarbons (PAH) undergo biotransformation to become genotoxic agents. Cytochrome p450 (CYP) 1B1 is an enzyme catalysing this transformation. Consumption of fruit and vegetables is considered to be protective against carcinogenesis, and naringenin can be found abundantly in citrus fruits. In the present study, the effect of naringenin on the regulation of CYP1B1 was investigated in MCF-7 cells. Enzyme inhibition assays revealed that naringenin inhibited CYP1B1 at or above 5 μm but not CYP1A1 activity. Quantitative PCR analysis also demonstrated that 1 μm-naringenin reduced CYP1B1 mRNA expression induced by 7,12-dimethylbenz(α)anthracene (DMBA). Further study illustrated that the suppression was at the transcriptional level. Since previous studies have shown that oestrogen response element (ERE) and xenobiotic-responsive element (XRE) are functional binding sequences in the promoter region of CYP1B1, interference of DNA binding on these two elements was pursued. Employing reporter gene assays as well as the electromobility shift assay, we verified that naringenin counteracted DMBA-induced XRE binding at − 1675. These results supported the notion that fruit consumption could be a protective measure against PAH biotransformation.
Hydration biomarkers in free-living adults with different levels of habitual fluid consumption
Authors: Perrier Erica , Vergne Sébastien , Klein Alexis , Poupin Marie , Rondeau Pascale , Le Bellego Laurent , Armstrong Lawrence E. , Lang Florian , Stookey Jodi , Tack Ivan 
Published: August 2012

Little is known about the impact of habitual fluid intake on physiology. Specifically, biomarkers of hydration status and body water regulation have not been adequately explored in adults who consume different fluid volumes in everyday conditions, without prolonged exercise or environmental exposure. The purpose of the present study was to compare adults with habitually different fluid intakes with respect to biomarkers implicated in the assessment of hydration status, the regulation of total body water and the risk of kidney pathologies. In the present cross-sectional study, seventy-one adults (thirty-two men, thirty-nine women, age 25–40 years) were classified according to daily fluid intake: thirty-nine low drinkers (LD; ≤ 1·2 litres/d) and thirty-two high drinkers (HD; 2–4 litres/d). During four consecutive days, urinary parameters (first morning urine (FMU) on day 1 and subsequent 24 h urine (24hU) collections), blood parameters, and food and beverage intake were assessed. ANOVA and non-parametric comparisons revealed significant differences between the LD and HD groups in 24hU volume (1·0 (se 0·1) v. 2·4 (se 0·1) litres), specific gravity (median 1·023 v. 1·010), osmolality (767 (se 27) v. 371 (se 33) mOsm/kg) and colour (3·1 (se 0·2) v. 1·8 (se 0·2)). Similarly, in the FMU, the LD group produced a smaller amount of more concentrated urine. Plasma cortisol, creatinine and arginine vasopressin concentrations were significantly higher among the LD. Plasma osmolality was similar between the groups, suggesting physiological adaptations to preserve plasma osmolality despite low fluid intake. The long-term impact of adaptations to preserve plasma osmolality must be examined, particularly in the context of renal health.
Consumption of blueberries with a high-carbohydrate, low-fat breakfast decreases postprandial serum markers of oxidation
Authors: Blacker Bryan C. , Snyder Shannon M. , Eggett Dennis L. , Parker Tory L. 
Published: August 2012

We sought to determine whether consumption of blueberries could reduce postprandial oxidation when consumed with a typical high-carbohydrate, low-fat breakfast. Participants (n14) received each of the three treatments over 3 weeks in a cross-over design. Treatments consisted of a high blueberry dose (75 g), a low blueberry dose (35 g) and a control (ascorbic acid and sugar content matching that of the high blueberry dose). Serum oxygen radical absorbance capacity (ORAC), serum lipoprotein oxidation (LO) and serum ascorbate, urate and glucose were measured at fasting, and at 1, 2 and 3 h after sample consumption. The mean serum ORAC was significantly higher in the 75 g group than in the control group during the first 2 h postprandially, while serum LO lag time showed a significant trend over the 3 h for both blueberry doses. Changes in serum ascorbate, urate and glucose were not significantly different among the groups. To our knowledge, this is the first report that has demonstrated that increased serum antioxidant capacity is not attributable to the fructose or ascorbate content of blueberries. In summary, a practically consumable quantity of blueberries (75 g) can provide statistically significant oxidative protectionin vivoafter a high-carbohydrate, low-fat breakfast. Though not tested directly, it is likely that the effects are due to phenolic compounds, either directly or indirectly, as they are a major family of compounds in blueberries with potential bioactive activity.
Foraging dives of sperm whales in the north-western Mediterranean Sea
Authors: Gannier Alexandre , Petiau Estelle , Dulau Violaine , Rendell Luke 
Published: August 2012

Oceanic odontocetes rely on echolocation to forage on pelagic or benthic prey, but their feeding ecology is difficult to study. We studied sperm whale foraging dives during summer in the north-western Mediterranean, using visual and passive acoustic observations. Clicking and creaking activities were recorded during dives of focal whales, at distances <3000 m using a towed hydrophone and DAT recorder. A total of 52 sperm whales were recorded over at least one full dive cycle. Data were obtained for 156 complete dives in total, including sequences of up to nine consecutive dives. Various dive and environmental variables were entered in multiple linear regression and principal components analysis, as well as estimated mass of whales. Creak rate was 0.80 creak/minute on average, with moderate variance. Bigger whales tended to dive longer at greater depths (as suggested by ascent durations), and emitted more creaks during a dive: 20.2 creaks/dive on average for individuals <24 tons, compared to 25.6 creaks/dive for animals >24 tons of estimated mass. For individual whales, creak rates did not vary significantly with size (range 0.78–0.80 creak/minute), but decreased with time of the day, and increased for shorter foraging phases. For different dives, higher creak rates were also observed earlier in the day, and linked to shorter foraging phases and surface durations. Although the exact significance of creak emissions (i.e. foraging attempt or prey capture) is not precisely determined, creak rates may be reliably used to quantify sperm whale foraging when single animal dives can be followed acoustically.
Surface anatomical profile of the cerebral cortex in obsessive–compulsive disorder: a study of cortical thickness, folding and surface area
Authors: Fan Q. , Palaniyappan L. , Tan L. , Wang J. , Wang X. , Li C. , Zhang T. , Jiang K. , Xiao Z. , Liddle P. F. 
Published: August 2012

BackgroundStudying the distribution of anatomical abnormalities over the entire cortical surface can help to identify key neural circuits implicated in generating symptoms of neuropsychiatric disorders. There is a significant inconsistency among studies investigating the neuroanatomy of obsessive–compulsive disorder (OCD) because of the confounding influence of co-morbid depression and medication use and the lack of unbiased estimation of whole-brain morphometric changes. It is also unknown whether the distinct surface anatomical properties of thickness, surface area and gyrification, which collectively contribute to grey matter volume (GMV), are independently affected in OCD.MethodThe cortical maps of thickness, gyrification and surface areal change were acquired from 23 unmedicated OCD patients and 20 healthy controls using an unbiased whole-brain surface-based morphometric (SBM) method to detect regional changes in OCD. Subcortical structures were not assessed in this study.ResultsPatients showed a significant increase in the right inferior parietal cortical thickness. Significant increases in gyrification were also noted in the left insula, left middle frontal and left lateral occipital regions extending to the precuneus and right supramarginal gyrus in OCD. Areal contraction/expansion maps revealed no significant regional differences between the patients and controls. In patients, gyrification of the insula significantly predicted the symptom severity measured using Yale–Brown Obsessive–Compulsive Scale (YBOCS).ConclusionsAn alteration in the cortical surface anatomy is an important feature of OCD seen in unmedicated samples that relates to the severity of the illness. The results underscore the presence of a neurodevelopmental aberration underlying the pathophysiology of OCD.
Persistence of cognitive impairment and its negative impact on psychosocial functioning in lithium-treated, euthymic bipolar patients: a 6-year follow-up study
Authors: Mora E. , Portella M. J. , Forcada I. , Vieta E. , Mur M. 
Published: August 2012

BackgroundPrevious cross-sectional studies report that cognitive impairment is associated with poor psychosocial functioning in euthymic bipolar patients. There is a lack of long-term studies to determine the course of cognitive impairment and its impact on functional outcome.MethodA total of 54 subjects were assessed at baseline and 6 years later; 28 had DSM-IV TR bipolar I or II disorder (recruited, at baseline, from a Lithium Clinic Program) and 26 were healthy matched controls. They were all assessed with a cognitive battery tapping into the main cognitive domains (executive function, attention, processing speed, verbal memory and visual memory) twice over a 6-year follow-up period. All patients were euthymic (Hamilton Rating Scale for Depression score lower than 8 and Young mania rating scale score lower than 6) for at least 3 months before both evaluations. At the end of follow-up, psychosocial functioning was also evaluated by means of the Functioning Assessment Short Test.ResultsRepeated-measures multivariate analysis of covariance showed that there were main effects of group in the executive domain, in the inhibition domain, in the processing speed domain, and in the verbal memory domain (p<0.04). Among the clinical factors, only longer illness duration was significantly related to slow processing (p=0.01), whereas strong relationships were observed between impoverished cognition along time and poorer psychosocial functioning (p<0.05).ConclusionsExecutive functioning, inhibition, processing speed and verbal memory were impaired in euthymic bipolar out-patients. Although cognitive deficits remained stable on average throughout the follow-up, they had enduring negative effects on psychosocial adaptation of patients.
Ruelle operator with weakly contractive iterated function systems
Authors: YE YUAN-LING 
Published: August 2012

AbstractThe Ruelle operator has been studied extensively both in dynamical systems and iterated function systems (IFSs). Given a weakly contractive IFS $(X, \{w_j\}_{j=1}^m)$ and an associated family of positive continuous potential functions $\{p_j\}_{j=1}^m$, a triple system $(X, \{w_j\}_{j=1}^m, \{p_j\}_{j=1}^m)$is set up. In this paper we study Ruelle operators associated with the triple systems. The paper presents an easily verified condition. Under this condition, the Ruelle operator theorem holds provided that the potential functions are Dini continuous. Under the same condition, the Ruelle operator is quasi-compact, and the iterations sequence of the Ruelle operator converges with a specific geometric rate, if the potential functions are Lipschitz continuous.
A new variable structure controller for robot manipulators with a nonlinear PID sliding surface
Authors: Atia Khaled R. 
Published: August 2012

SUMMARYIn this paper a new sliding mode controller for set-point control of robot manipulators is proposed. The controller does not use any part of the robot dynamics in the control law. Thus, it is structurally simpler than other sliding mode controllers where the control law uses a nominal model of the robot dynamics. The controller uses a new nonlinear Proportional-Integral-Derivative (PID) sliding surface. The stability of the controlled robot dynamics is proved. On applying the boundary-layer approach to remove chattering, a nonlinear PID controller exists inside the boundary layer. This PID controller ensures that the error tend to zero asymptotically if there is no disturbances applied to the robot dynamics.