bluuebunny/crossref_metadata_2025_split huggingface dataset:
Childhood trauma and differential response to long-term psychoanalytic versus cognitive–behavioural therapy for chronic depression in adults
Authors: Krakau Lina , Ernst Mareike , Hautzinger Martin , Beutel Manfred E. , Leuzinger-Bohleber Marianne 
Published: August 2024

BackgroundChildhood trauma is a major risk factor for chronic depression. It has been suggested that adults with chronic depression who have experienced childhood trauma may require long-term treatment owing to a breakdown of basic trust and related difficulties in developing a productive therapeutic relationship.AimsAs empirical studies have been preliminary and scarce, we studied the effects of psychoanalytic therapy (PAT) versus cognitive–behavioural therapy (CBT) for chronic depression in adults with a history of childhood trauma. In this subgroup, we expected a greater symptom reduction in PAT compared with CBT.MethodIn a large trial of long-term psychotherapies for chronic depression (LAC-Study; Clinical Trial Register ISRCTN91956346), 210 adults received open-ended CBT or PAT in an out-patient setting and were examined yearly over 5 years on the Beck Depression Inventory – II (BDI-II). Based on a linear mixed model approach, we tested participant-reported childhood trauma based on the Childhood Trauma Questionnaire (CTQ) as a predictor and moderator of treatment outcome. CTQ subscales were examined exploratively.ResultsDepressive symptoms decreased over time (b = −4.55, s.e. = 0.90, 95% CI −6.32 to −2.81, T = −5.08; P < 0.001). A significant three-way interaction between childhood trauma, time and therapy group (b = −0.05, s.e. = 0.02, 95% CI −0.09 to −0.01, T = −2.42; P = 0.016) indicated that participants with childhood trauma profited especially well from PATs.ConclusionsOur results indicate differential benefits from PAT compared with CBT among adults with chronic depression and a history of childhood trauma. The results have important implications for differential indication and policy.
Therapeutic Potential of Blocking Nephrin Phosphorylation to Improve Pancreatic β-cell Function
Authors: Joseph Jamie W 
Published: August 2024

Abstract
The phosphorylation of the transmembrane protein nephrin has been shown to play an important role in signaling in kidney podocytes, and it has now been shown to also play a key role in regulating pancreatic β-cell function. Williamson et al have recently shown that the loss of nephrin tyrosine phosphorylation on its 3 cytoplasmic YDxV motifs can enhance insulin release in aged female mice. These studies suggest that blocking nephrin phosphorylation may be an effective treatment option for improving β-cell function.
The Limits to Food and Beverage Industry Influence over Fiscal and Regulatory Policy in Latin America
Authors: Gómez Eduardo J. 
Published: August 2024

Abstract
Context: Little is known about the political, institutional, and social contexts contributing to a decline in food and beverage industry power and influence over fiscal policy (soda taxes) and regulatory policy (sales/advertising restrictions and food labels). This article addresses this issue by exploring why Mexico and Chile eventually saw such a decline in the food and beverage industry's influence, whereas a similar decline did not occur in Brazil. The article argues that in Mexico and Chile, these outcomes are explained by presidential, congressional, and bureaucratic interests shifting to pursue policies that went against industry preferences.
Methods: This article took a qualitative methodological approach to comparative historical research.
Findings: Policy makers’ interest in pursuing stronger food and beverage regulations were shaped by economic and public health concerns, new electoral contexts, epidemiological information, and normative beliefs. In Mexico, the infiltration of nutrition researchers within government facilitated this process. By contrast, Brazil's government was divided about pursuing regulatory policies, with presidents favoring partnerships with industry to implement a popular antihunger program; industry's power endured there with limited progress in policy reforms.
Conclusion: Governments can eventually overcome industry power and policy influence, but it depends on a whole-government commitment to reform.
Actin network evolution as a key driver of eukaryotic diversification
Authors: Velle Katrina B. , Swafford Andrew J. M. , Garner Ethan , Fritz-Laylin Lillian K. 
Published: August 2024

ABSTRACT
Eukaryotic cells have been evolving for billions of years, giving rise to wildly diverse cell forms and functions. Despite their variability, all eukaryotic cells share key hallmarks, including membrane-bound organelles, heavily regulated cytoskeletal networks and complex signaling cascades. Because the actin cytoskeleton interfaces with each of these features, understanding how it evolved and diversified across eukaryotic phyla is essential to understanding the evolution and diversification of eukaryotic cells themselves. Here, we discuss what we know about the origin and diversity of actin networks in terms of their compositions, structures and regulation, and how actin evolution contributes to the diversity of eukaryotic form and function.
Force re-development after shortening reveals a role for titin in stretch–shortening performance enhancement in skinned muscle fibres
Authors: Tomalka André , Weidner Sven , Hahn Daniel , Seiberl Wolfgang , Siebert Tobias 
Published: August 2024

ABSTRACT
Stretch–shortening cycles (SSCs) involve muscle lengthening (eccentric contractions) instantly followed by shortening (concentric contractions). This combination enhances force, work and power output compared with pure shortening contractions, which is known as the SSC effect. Recent evidence indicates both cross-bridge (XB)-based and non-XB-based (e.g. titin) structures contribute to this effect. This study analysed force re-development following SSCs and pure shortening contractions to gain further insight into the roles of XB and non-XB structures regarding the SSC effect. Experiments were conducted on rat soleus muscle fibres (n=16) with different SSC velocities (30%, 60% and 85% of maximum shortening velocity) and constant stretch–shortening magnitudes (18% of optimum length). The XB inhibitor blebbistatin was used to distinguish between XB and non-XB contributions to force generation. The results showed SSCs led to significantly greater [mean±s.d. 1.02±0.15 versus 0.68±0.09 (ΔF/Δt); t62=8.61, P&lt;0.001, d=2.79) and faster (75 ms versus 205 ms; t62=−6.37, P&lt;0.001, d=−1.48) force re-development compared with pure shortening contractions in the control treatment. In the blebbistatin treatment, SSCs still resulted in greater [0.11±0.03 versus 0.06±0.01 (ΔF/Δt); t62=8.00, P&lt;0.001, d=2.24) and faster (3010±1631 versus 7916±3230 ms; t62=−8.00, P&lt;0.001, d=−1.92) force re-development compared with pure shortening contractions. These findings deepen our understanding of the SSC effect, underscoring the involvement of non-XB structures such as titin in modulating force production. This modulation is likely to involve complex mechanosensory coupling from stretch to signal transmission during muscle contraction.
Surgical Outcome After Distal Pancreatectomy With and Without Portomesenteric Venous Resection in Patients with Pancreatic Adenocarcinoma: A Transatlantic Evaluation of Patients in North America, Germany, Sweden, and The Netherlands (GAPASURG)
Authors: Stoop Thomas F. , Augustinus Simone , Björnsson Bergthor , Tingstedt Bobby , Andersson Bodil , Wolfgang Christopher L. , Werner Jens , Johansen Karin , Stommel Martijn W. J. , Katz Matthew H. G. , Ghadimi Michael , House Michael G. , Ghorbani Poya , Molenaar I. Quintus , de Wilde Roeland F. , Mieog J. Sven D. , Keck Tobias , Wellner Ulrich F. , Uhl Waldemar , Besselink Marc G. , Pitt Henry A. , Del Chiaro Marco ,   for the Global Audits on Pancreatic Surgery Group (GAPASURG), Mackay Tara M. , Rodriguez Franco Salvador , Dierenvan Dieren Susan 
Published: August 2024

Abstract
Background
Pancreatic adenocarcinoma located in the pancreatic body might require a portomesenteric venous resection (PVR), but data regarding surgical risks after distal pancreatectomy (DP) with PVR are sparse. Insight into additional surgical risks of DP-PVR could support preoperative counseling and intraoperative decision making. This study aimed to provide insight into the surgical outcome of DP-PVR, including its potential risk elevation over standard DP.

Methods
We conducted a retrospective, multicenter study including all patients with pancreatic adenocarcinoma who underwent DP ± PVR (2018–2020), registered in four audits for pancreatic surgery from North America, Germany, Sweden, and The Netherlands. Patients who underwent concomitant arterial and/or multivisceral resection(s) were excluded. Predictors for in-hospital/30-day major morbidity and mortality were investigated by logistic regression, correcting for each audit.

Results
Overall, 2924 patients after DP were included, of whom 241 patients (8.2%) underwent DP-PVR. Rates of major morbidity (24% vs. 18%; p = 0.024) and post-pancreatectomy hemorrhage grade B/C (10% vs. 3%; p = 0.041) were higher after DP-PVR compared with standard DP. Mortality after DP-PVR and standard DP did not differ significantly (2% vs. 1%; p = 0.542). Predictors for major morbidity were PVR (odds ratio [OR] 1.500, 95% confidence interval [CI] 1.086–2.071) and conversion from minimally invasive to open surgery (OR 1.420, 95% CI 1.032–1.970). Predictors for mortality were higher age (OR 1.087, 95% CI 1.045–1.132), chronic obstructive pulmonary disease (OR 4.167, 95% CI 1.852–9.374), and conversion from minimally invasive to open surgery (OR 2.919, 95% CI 1.197–7.118), whereas concomitant PVR was not associated with mortality.

Conclusions
PVR during DP for pancreatic adenocarcinoma in the pancreatic body is associated with increased morbidity, but can be performed safely in terms of mortality.
Information Design and Sharing in Supply Chains
Authors: Caldentey René , Giloni Avi , Hurvich Clifford , Zhang Yichen 
Published: August 2024

We study the interplay between inventory replenishment policies and information sharing in the context of a two-tier supply chain with a single supplier and a single retailer serving an independent and identically distributed Gaussian market demand. We investigate how the retailer’s inventory policy impacts the supply chain’s cumulative expected long-term average inventory costs [Formula: see text] in two extreme information-sharing cases: (a) full information sharing and (b) no information sharing. To find the retailer’s inventory policy that minimizes [Formula: see text], we formulate an infinite-dimensional optimization problem whose decision variables are the MA([Formula: see text]) coefficients that characterize a stationary ordering policy. Under full information sharing, the optimization problem admits a simple solution and the optimal policy is given by an MA(1) process. On the other hand, to solve the optimization problem under no information sharing, we reformulate the optimization from its time domain formulation to an equivalent z-transform formulation in which the decision variables correspond to elements of the Hardy space H2. This alternative representation allows us to use a number of results from H2 theory to compute the optimal value of [Formula: see text] and characterize a sequence of ϵ-optimal inventory policies under some mild technical conditions. By comparing the optimal solution under full information sharing and no information sharing, we derive a number of important practical takeaways. For instance, we show that there is value in information sharing if and only if the retailer’s optimal policy under full information sharing is not invertible with respect to the sequence of demand shocks. Furthermore, we derive a fundamental mathematical identity that reveals the value of information sharing by exploiting the canonical Smirnov–Beurling inner–outer factorization of the retailer’s orders when viewed as an element of H2. We also show that the value of information sharing can grow unboundedly when the cumulative supply chain costs are dominated by the supplier’s inventory costs. Funding: R. Caldentey acknowledges the University of Chicago Booth School of Business for financial support. Supplemental Material: The online appendix is available at https://doi.org/10.1287/moor.2023.008 .
Understanding cervical cancer awareness in hard-to-reach areas of Bangladesh: A cross-sectional study involving women and household decisionmakers
Authors: Nazrul Naheed , de Fouw Marlieke , Beltman Jogchum J. , de Zeeuw Janine , Schans Jurjen van der , Koot Jaap , Rasul Kazi Golam , Kulsum Mosamat Umma , Ahmed Md Shahnur , Rahman Anika , Rahman Aminur , Islam Kazi Maruful , Nessa Ashrafun , Campbell Christine , Stekelenburg Jelle 
Published: August 2024

Introduction
In Bangladesh, the uptake of cervical cancer screening is low. Lack of knowledge and understanding of symptoms and risk factors contributes to low screening uptake. The purpose of this study was to explore the knowledge of cervical cancer risk factors and symptoms and to measure the association with socio-demographic characteristics among women and household decisionmakers living in hard-to-reach areas of Bangladesh.

Methods
A cross-sectional survey was conducted in five districts in Bangladesh among women aged between 30 and 60 years, their husbands, and their mothers-in-law from April to September 2022. Data were collected using a modified version of the validated AWACAN questionnaire tool. The significance level was considered at p-value <0.05 and odds ratios with 95% confidence.

Results
Nearly 50% of participating women in hard-to-reach areas of Bangladesh and their family decisionmakers had low levels of knowledge of the risk factors and symptoms of cervical cancer. Only 20% of respondents in our survey knew about HPV, the most important risk factor for developing cervical cancer. Most respondents were familiar with the terminology of cervical cancer as a disease; however, approximately 40% of respondents did not know that not adhering to cervical cancer screening could be seen as a risk factor. Women do not make decisions about participation in cervical cancer screening on their own. Knowledge of cervical cancer risk factors and symptoms among decisionmakers was significantly associated with higher education and higher household monthly expenditure.

Conclusion
Women, their husbands, and mothers-in-law in hard-to-reach areas of Bangladesh had limited knowledge about cervical cancer risk factors and symptoms. Engaging these key decision-makers in targeted health education is vital to improve screening uptake. Conduction of future research to identify and address screening barriers is also essential for effective prevention efforts.
COVID-19 vaccination uptake in remote areas—Evidence from a panel survey in Bangladesh
Authors: Rudolph Lukas , Koubi Vally , Freihardt Jan 
Published: August 2024

Background
Vaccination has proven to be an essential strategy in combating the COVID-19 pandemic. This study aims to discern the factors influencing both the intentions for and actual behavior regarding COVID-19 vaccination among remote, rural populations in Bangladesh.

Methods
The study utilized panel survey data comprising 1,698 randomly selected household heads. These are predominantly illiterate, of Muslim religion, middle-aged, and male, with agriculture or day labor as primary income source. They reside in 36 locations distributed along the whole 250 km length of the Jamuna River in Bangladesh. Data collection occurred through face-to-face and telephone interviews conducted between September 2021 and October 2022. Descriptive statistics and Ordinary Least Squares regression models were employed to assess influence factors for COVID-19 vaccination intentions and uptake. The analyses considered the constructs of the Health Belief Model alongside sociodemographic characteristics such as gender, age, religion, education, and income source.

Results
Survey respondents showed a notably high willingness to receive the COVID-19 vaccine promptly upon its availability. However, the effectiveness of the Health Belief Model in elucidating COVID-19 vaccination uptake was limited, except for its availability component. Older individuals, those with higher levels of education, and individuals employed in government or formal sector occupations were prompt in receiving the COVID-19 vaccine as it became available. Gender, religion, and the presence of dependents in the household did not exert a significant influence on vaccination uptake.

Conclusions
The results indicate that a strong willingness to receive the COVID-19 vaccine correlated with an increased likelihood of vaccine uptake once it was available. These findings suggest that a widespread distribution of COVID-19 vaccines to low-income and remote areas could have served as a vital strategy in mitigating the COVID-19 pandemic.
TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure
Authors: Zhou Jiani , Wu Chaoqun , Zhao Miaohui 
Published: August 2024

Background
This study aimed to determine the roles of interleukin (IL)-17, TAO kinase 1 (TAOK1), and NOD-like receptor protein 3 (NLRP3) in cardiomyocyte pyroptosis and proliferation.

Methods
The IL-17-treated H9C2 cells were used as in vitro heart failure (HF) models. These cells were subjected to TAOK1 overexpression or knockdown and treated with BMS-986299 (NLRP3 inflammasome agonist), MCC950 (NLRP3 inflammasome inhibitor), or verteporfin (Yes-associated protein [YAP] inhibitor). Thereafter, their pyroptosis, proliferative capacity, and gene and protein expression levels were detected. Doxorubicin-induced HF rats were used as in vivo models and subjected to TAOK1 overexpression. Thereafter, their myocardial pathology, NLRP3 inflammasome-mediated pyroptosis, and YAP/TEAD pathway function were evaluated.

Results
IL-17 treatment increased the pyroptosis and decreased the proliferative capacity of H9C2 cells. Additionally, IL-17 treatment inducedto the activation of the NLRP3 inflammasomes and inhibition of the YAP/TEAD pathway in the H9C2 cells. Moreover, the IL-17-mediated effects on the H9C2 cells were alleviated by TAOK1 overexpression and augmented by TAOK1 knockdown. Furthermore, treatment with BMS-986299 or verteporfin affected the pyroptosis, proliferative capacity, and NLRP3 inflammasome activation of the H9C2 cells independently of TAOK1 expression. In the doxorubicin-induced HF rat model, TAOK1 overexpression mitigated myocardial injury, suppressed NLRP3 inflammasome pathway activation, and restored the YAP/TEAD pathway activity.

Conclusion
TAOK1 played a crucial role in regulating IL-17-mediated increase in the pyroptosis and decrease in the proliferation of cardiomyocytes by regulating the activities of the NLRP3 inflammasomes and the YAP/TEAD pathway.
Penitencia cuaresmal como medicina del alma. Nueva edición de un sermón de Cuaresma de San Vicente Ferrer
Authors: Rubio Josep E. 
Published: August 2024

Abstract
The sermons preached in Valencia by Saint Vincent Ferrer during Lent in the year 1413 are an excellent model of the type of preaching carried out by the Valencian Dominican. This article offers a critical edition of one of these sermons (number XXVI, with the theme “Erat praedicans in synagogis Galilaeae”) accompanied by explanatory notes on its structure and content, as well as the identification of the theological sources used by the preacher. Thus, a model is offered for a complete reissue of the sermonary, the need for which is evident in the modifications introduced with respect to previous editions.
Amor y diálogo en la trama trovadoresca
Authors: González Déborah 
Published: August 2024

Abstract
In the cantigas de amor – the main genre adopted by Galician-Portuguese troubadours – the speech uttered by the lyrical voice of the male lover in confessing his love or love-sorrow occasionally appears in alternation with the voice of the lady, who intervenes to offer her response. Our attention here will focus, in the first place, on the compositions in which a direct alternation of these voices can be found within the stanzas, as well as on Airas Moniz’s cantiga spoken in cobras. Due to the particularities of the latter at a structural and formal level, this alternation can be seen in relation to the definition of the tenção of the Galician-Portuguese poetic treatise Arte de Trovar, which indicates that cantigas of this type «se podem fazer d'amor ou d'amigo ou d'escarnho ou de maldizer» (can be used for love or friendship or to mock or curse). Our interest in the dialogic model extends to the non-fictional tenções between troubadours, since in several of these the adoption and/or recreation of motifs and topics equally associated with courtly love can be seen.
Origine dell’it. anche e dei suoi correlati romanzi
Authors: Nocentini Alberto 
Published: August 2024

Abstract
The origin of it. anche ‘also, too’ and of its Romance cognates is commonly traced back to Protoromance *anque, a reconstructed form, which is interpreted as a derivative of the dubitative Latin particle an. This explanation turns out to be untenable, because it does not account for the primitive meanings of anche and its Romance cognates, that is ‘still’ and ‘never’, as is evident from the oldest records of the Romance languages. Therefore, Nicholson’s hypothesis of a derivation from Latin antequam is reconsidered through the meanings of ‘before this time’, ‘up to this time’, which later evolved to ‘still, yet’ and ‘never’ in a negative context. The mechanism whereby a conjunction may become an adverb through the ellipsis of the verb is shown by quoting parallel examples in Italian.