bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistive Switching Acceleration Induced by Thermal Confinement
Authors: Sarantopoulos Alexandros , Lange Kristof , Rivadulla Francisco , Menzel Stephan , Dittmann Regina 
Published: August 2024

AbstractEnhancing the switching speed of oxide‐based memristive devices at a low voltage level is crucial for their use as non‐volatile memory and their integration into emerging computing paradigms such as neuromorphic computing. Efforts to accelerate the switching speed often result in an energy trade‐off, leading to an increase in the minimum working voltage. In this study, an innovative solution is presented: the introduction of a low thermal conductivity layer placed within the active electrode, which impedes the dissipation of heat generated during the switching process. The result is a notable acceleration in the switching speed of the memristive model system SrTiO3 by a remarkable factor of 103, while preserving the integrity of the switching layer and the interfaces with the electrodes, rendering it adaptable to various filamentary memristive systems. The incorporation of HfO2 or TaOx as heat‐blocking layers not only streamlines the fabrication process but also ensures compatibility with complementary metal‐oxide‐semiconductor technology.
A numerical comparison of heavy‐purge and dual‐reflux strategies in pressure swing adsorption for methane enrichment
Authors: Hu Guoping , Guo Yalou , Luo Jinbiao , Xiao Gongkui , Weh Roman , Li Kevin Gang , Qi Tao , Webley Paul A. , May Eric F. 
Published: August 2024

AbstractDual reflux pressure swing adsorption (DR‐PSA) has been regarded as a state‐of‐the‐art adsorption‐based process which can simultaneously obtain two streams of pure product gases with a narrow pressure window. However, the DR‐PSA has not yet been reported in industrial applications. Herein, a DR‐PSA and a heavy‐purge pressure vacuum swing adsorption (HP‐PVSA) were numerically investigated for the enrichment of 1%, 8% and 15% CH4 from N2 gas mixtures in pilot‐scale. Key separation indicators such as purity, recovery and energy cost of the two cycles were compared to analyze the limitations of the DR‐PSA process while scaling‐up. This study reveals the impact of heavy to feed (H/F) ratios on purity and recovery for both cycles and analyses the energy consumption of each process. For feed gas with 15% CH4, while DR‐PSA can achieve a slightly better purity and recovery (88.3% and 88.3%, respectively) compared to HP‐PVSA (87.5% and 80.3%, respectively), it also involves an order of magnitude higher energy consumption (181.6 versus 24.6 kJ/mol CH4 captured). DR‐PSA shows significantly superior performance than HP‐PVSA when the CH4 content in the raw feed gas is low. Under the investigated operating conditions, HP‐PVSA can only enrich 1% CH4 to 10% with 78.7% recovery while DR‐PSA can obtain 75.3% purity and 77.3% recovery. Results indicate that DR‐PSA exhibits superiority in enrichment of dilute gas, however, its high energy consumption, high capital expenditures and limitations in processing high throughput are the chief reasons hindering its industrial application.
Higher survival following transplantation with a mismatched unrelated donor with posttransplant cyclophosphamide‐based graft‐versus‐host disease prophylaxis than with double unit umbilical cord blood in patients with acute myeloid leukemia in first complete remission: A study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Authors: Baron Frédéric , Labopin Myriam , Versluis Jurjen , Vydra Jan , von dem Borne Peter A. , Nicholson Emma , Blaise Didier , Protheroe Rachel , Kulagin Alexander , Bulabois Claude Eric , Rovira Montserrat , Chevallier Patrice , Forcade Edouard , Byrne Jenny , Sanz Jaime , Ruggeri Annalisa , Mohty Mohamad , Ciceri Fabio 
Published: August 2024

AbstractThe best donor option for acute myeloid leukemia (AML) patients lacking an HLA‐matched donor has remained intensively debated. We herein report the results of a large retrospective registry study comparing hematopoietic cell transplantation (HCT) outcomes between double‐unit umbilical cord blood transplantation (dCBT, n = 209) versus 9/10 HLA‐matched unrelated donor (UD) with posttransplant cyclophosphamide (PTCy)‐based graft‐versus‐host disease (GVHD) prophylaxis (UD 9/10, n = 270) in patients with AML in first complete remission (CR1). Inclusion criteria consisted of adult patient, AML in CR1 at transplantation, either peripheral blood stem cells (PBSC) from UD 9/10 with PTCy as GVHD prophylaxis or dCBT without PTCy, transplantation between 2013 and 2021, and no in vivo T‐cell depletion. The 180‐day cumulative incidence of grade II‐IV acute GVHD was 29% in UD 9/10 versus 44% in dCBT recipients (p = .001). After adjustment for covariates, dCBT recipients had a higher non‐relapse mortality (HR = 2.35, 95% CI: 1.23–4.48; p = .01), comparable relapse incidence (HR = 1.12, 95% CI: 0.67–1.86; p = .66), lower leukemia‐free survival (HR = 1.5, 95% CI: 1.01–2.23; p = .047), and lower overall survival (HR = 1.66, 95% CI: 1.08–2.55; p = .02) compared with patients receiving UD 9/10 HCT. In summary, our results suggest that transplantation outcomes are better with UD 9/10 with PTCy‐based GVHD prophylaxis than with dCBT for AML patients in CR1. These data might support the use of UD 9/10 with PTCy‐based GVHD prophylaxis over dCBT in AML patients lacking an HLA‐matched donor.
Metal–Organic Frameworks for Electrocatalytic CO2 Reduction: From Catalytic Site Design to Microenvironment Modulation
Authors: Zhang Chengming , Lin Zhongyuan , Jiao Long , Jiang Hai‐Long 
Published: August 2024

AbstractThe electrochemical reduction of CO2 to high‐value carbon‐based chemicals provides a sustainable approach to achieving an artificial carbon cycle. In the decade, metal–organic frameworks (MOFs), a kind of porous crystalline porous materials featuring well‐defined structures, large surface area, high porosity, diverse components, easy tailorability, and controllable morphology, have attracted considerable research attention, serving as electrocatalysts to drive CO2 reduction. In this review, the reaction mechanisms of electrochemical CO2 reduction and the structure/component advantages of MOFs meeting the requirements of electrocatalysts for CO2 reduction are analyzed. After that, the representative progress for the precise fabrication of MOF‐based electrocatalysts for CO2 reduction, focusing on catalytic site design and microenvironment modulation, are systemically summarized. Furthermore, the emerging applications and promising research for more practical scenarios related to electrochemical CO2 conversion are specifically proposed. Finally, the remaining challenges and future outlook of MOFs for electrochemical CO2 reduction are further discussed.
Concise Synthesis of Cyctetryptomycin A and B Enabled by Zr‐Catalyzed Dimerization
Authors: Yu Longhui , Ogawa Hiroshige , Li Shangzhao , Lam Cheung Tsoh , Liu Wenchao , Yan Dexiu , Matsuda Yudai , Kobayashi Yusuke , Guo Zhihong , Ikeda Kotaro , Hamlin Trevor A. , Yamazaki Ken , Qian Pei‐Yuan , Nakamura Hugh 
Published: August 2024

AbstractA concise synthetic strategy utilizing a Zr catalyst for the construction of cyctetryptomycin A and B is reported. Cyctetryptomycin A and B are recently isolated, complex tetrameric natural products for which total synthesis has not been previously reported. This study presents a practical approach for the construction of two consecutive quaternary carbon centers with a Zr catalyst. Furthermore, the first total synthesis of cyctetryptomycin A and B was achieved by this Zr‐catalyzed radical coupling. The radical dimerization reaction mediated by the Zr catalyst required 1,2‐bis(diphenylphosphino)ethane (dppe) as an indispensable additive. Through both experimental and theoretical investigations into the mechanism of this Zr‐catalyzed reaction, the specific role of dppe was elucidated. In addition, the synthetic approach was extended to enable the practical synthesis of other dimeric natural products, including tetratryptomycin A, dibrevianamide F, and ditryptophenaline. Finally, the synthetic mechanism of cyctetryptomycin A and B, through the oxidative macrocyclization of tetratryptomycin A by CttpC, was newly elucidated by both experimental and docking simulations.
Numerical investigation of electromagnetic [Cu + TiO2/H2O]h hybrid nanofluid flow with solar radiation over an exponential stretching surface
Authors: Venkateswarlu Bhumarapu , Joo Sang Woo , Nagendra Nallagundla , Metwally Ahmed Sayed M 
Published: August 2024

AbstractThe idea of a hybrid nanofluid (HNF) has sparked curiosity among many scientists because of its ability to enhance thermal characteristics, leading to elevated rates of heat transfer (HT). These HNFs are utilized in various engineering and industrial settings, such as electronics cooling, manufacturing, naval structures, biomedical applications, and drug delivery. The current study investigates the analysis of irreversibility in EMHD [Cu + TiO2/H2O]h flow over a stretching sheet with radiation and viscous dissipation. The governing PDEs are converted into ODEs using similarity variables. These ODEs are then solved using the RKF method along with a shooting technique. The effects of different physical parameters on the velocity and temperature distributions of the HNF, as well as on HT and surface drag force, are thoroughly examined and presented in graphs. The velocity of [TiO2/water]n flow declines as the magnetic field strength rises, but it rises with greater electric field values for [Cu + TiO2/water]h. The temperature of the [Cu + TiO2/water]h increases with elevated levels of radiation, Eckert number, and heat generation strength. Higher Reynolds and Brinkman numbers result in a rise in entropy generation for [Cu + TiO2/H2O]h, whereas the Bejan number decreases to the same extent. The HT rate in [Cu + TiO2/H2O]h increases by 3.05% as the Eckert number rises, while it drops by 4.01% when there is significant thermal radiation. Skin friction reduces by 3.21% in [TiO2/water]n as the electric field strength increases, whereas it decreases by 4.05% with an increase in magnetic field strength. These discoveries offer valuable perspectives on furthering the utilization of HNFs in engineering and industrial operations.
Poly(lactic acid)/poly(vinyl butyral) composites containing kaolin modified by acids and calcination
Authors: Lee Hayeong , Park Jeong‐Ho , Jang Keon‐Soo 
Published: August 2024

AbstractThe compatibility between two distinct polymers in the blend is important to maximize various properties of the blends. This study investigated the effects of kaolin modifications through acid and calcination treatments on the compatibility, molecular weight, its distribution, and various properties of poly(lactic acid) (PLA)/poly(vinyl butyral) (PVB) blends. In addition, the incorporation of the modified kaolin as a compatibilizer into the blends enhanced their mechanical and thermal properties, addressing the challenges of immiscibility between distinct polymers. The experimental approach included the utilization of scanning electron microscopy, gel permeation chromatography, differential scanning calorimetry, x‐ray diffraction, Fourier transform infrared spectroscopy, rheometer, and melt flow index to examine the structural, molecular, and thermal, mechanical and rheological behaviors of the composites. The changes in various molecular weights were correlated with other properties. The incorporation of surface‐treated kaolin into the blend improved the compatibility between PLA and PVB, exhibiting a singular melting temperature peak and a less distinct interface between two different polymers. This research contributed to the development of sustainable material solutions by demonstrating the potential of modified inorganic fillers in improving the performance of biodegradable polymer blends.
Advances in bioengineered CAR T/NK cell therapy for glioblastoma: Overcoming immunosuppression and nanotechnology‐based strategies for enhanced CAR T/NK cell therapy
Authors: Dana Nasim , Dabiri Arezou , Najafi Majed Bahri , Rahimi Azadeh , Ishaghi Sayed Mohammad Matin , Shariati Laleh , Shao Minmin , Borzacchiello Assunta , Rahimmanesh Ilnaz , Makvandi Pooyan 
Published: August 2024

AbstractGlioblastoma is a strong challenge in the worldwide field of central nervous system malignancies. GBM's inherent heterogeneity, along with the formation of an immunosuppressive tumor microenvironment, supports its resistance to current therapy methods. Immunotherapeutic methods have emerged as potential options in recent years. However, because of the inherent limits of traditional immunotherapeutic techniques innovative approaches are required. Advances in cut‐edge techniques provide a possible route for improving effector cell effectiveness. This review gives insight into the complicated immunosuppressive pathways in GBM, with a particular emphasis on CAR T/NK‐cell treatment as a potential achievement. Recognizing and addressing these concerns might open the way for more effective and focused glioblastoma therapies, providing hope for the future with the aim of improved outcomes for patients. In addition, this review presents valuable insights into the integration of nanotechnology into CAR T/NK cell therapy for enhanced efficiency of these personalized gene therapy products.
A Novel 3‐Benzyloxychromone From Celastrus orbiculatus Thunb. Exhibits Anticancer Effects on Non–Small Cell Lung Cancer Cells via GSK‐3β–Dependent c‐Jun/ATF2 Pathway
Authors: Ding Yanlin , Wang Tingye , Xu Zhenyu , Fu Yuxuan , Liu Yanqing , Tao Li 
Published: August 2024

ABSTRACTCelastrus orbiculatus Thunb. is a vine used as a traditional Chinese medicinal herb. In this study, we focused on the anticancer cytotoxicity and underlying mechanism of previously unreported 3‐oxygen–substituted isoflavone analogue (3‐benzyloxychromone, 3‐Boc) from the herb. Initially, we established cell line–derived xenograft mouse model using H1299 non–small cell lung cancer (NSCLC) cells and found that the ethanol crude extracts of the stem part of C. orbiculatus (200 mg/kg) could substantially suppress the growth of xenograft tumors in athymic nu/nu mice. We compared 3‐Boc with three other flavonoid analogues isolated from the stem part of C. orbiculatus. Among these, 3‐Boc showed the most potent cytotoxicity against H1299 and H1975 NSCLC cells. Colony formation, EdU incorporation and Annexin V‐FITC/PI apoptosis assays demonstrated that 3‐Boc induced growth inhibition primarily by inhibiting DNA replication and inducing apoptotic death of NSCLC cells. Structure‐based target prediction and MD simulation suggested that 3‐Boc potentially suppressed the activity of glycogen synthase kinase‐3β (GSK‐3β) by interacting with the ATP–binding site. Western blot analysis indicated that 3‐Boc triggered the phosphorylation of Serine 21 of GSK‐3α or Serine 9 of GSK‐3β in a time‐ and dose‐dependent manner. To investigate the dependency of GSK‐3β, we established GSK‐3β knockout in H1299 cells. Depletion of GSK‐3β enhanced 3‐Boc–induced cytotoxicity compared with wild‐type counterparts through activated c‐Jun/ATF2 signaling pathway. Altogether, our study highlights the anticancer potential of C. orbiculatus and the discovery of novel 3‐oxygen–substituted chromone from the herb, which may have important implications for screening promising modulators of GSK‐3β and related signaling pathways in the treatment of cancer.
Psychedelic‐assisted therapy for palliative care within a home treatment setting: A case report
Authors: Federico Seragnoli , Geo Martignoni , Entela Martignoni , Bachmann Silke , Elisa Rabitti , Silvio Cavuto , Zoë Dubus , Louise Penzenstadler , Gabriel Thorens , Joël Billieux , Daniele Zullino 
Published: August 2024

Key Clinical MessageThis case study describes the feasibility and safety of psychedelic‐assisted therapy (PAT) as a home‐based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well. This case supports the feasibility and safety of PAT for patients with life‐threatening conditions in a home setting.AbstractPsychedelic‐assisted therapy (PAT), as it is practiced today, merges traditional psychotherapeutic techniques with the use of psychedelics such as LSD, psilocybin, or MDMA with the aim of unlocking deeper insights in patients and treating mental conditions that are resistant to other forms of therapy. The present case study describes the safety of PAT as a home‐based intervention for a patient with throat cancer experiencing significant existential distress. The patient tolerated the intervention well and was asked to report on measures of anxiety, depression, and distress related to his somatic condition. The observations provided by this clinical case report align with previous findings, suggesting that PAT can be safely applied to potentially provide relief from existential distress in patients with life‐threatening conditions. As this is a single‐case study, generalizations should be made cautiously. Moreover, placebo effects, expectancy effects, and the natural course of the disease may influence outcomes. Future research should consider controlled trials to ascertain the efficacy and safety of such interventions in diverse settings.
From drug therapy failures to laser therapy victory: A case report and literature review of lupus miliaris disseminatus faciei resolution
Authors: Bazargan Afsaneh Sadeghzadeh , Roohaninasab Masoumeh , Kahjoogh Hossein Ahmadi , Aghdam Saba Baybordi , Taheri Amirmasoud , Jafarzadeh Alireza 
Published: August 2024

Key Clinical MessagePulsed dye laser (PDL) has proven effective in resolving lupus miliaris disseminatus faciei (LMDF) where drug therapies have failed with a lack of treatment consensus for LMDF, considering early PDL intervention is crucial to achieve resolution without scarring, prevent relapse, and enhance overall treatment outcomes.AbstractLupus miliaris disseminatus faciei (LMDF) is a rare inflammatory and granulomatous dermatologic disease that primarily affects the face. The optimal treatment for LMDF remains controversial, and there is a lack of consensus on the most effective therapy. This case report highlights the successful use of a 595 nm pulsed dye laser (PDL) in the treatment of LMDF following unsuccessful drug therapy. A 28‐year‐old male presented with reddish‐brown eruptions on his face that had persisted for several months. Clinical examination revealed discrete dome‐shaped eruptions in clusters on the central area of the face. Histopathological examination confirmed the diagnosis of LMDF, based on the presence of epithelioid granulomas with central caseous necrosis. Previous treatment with an oral isotretinoin and methotrexate combination also failed to yield satisfactory results. After discontinuing drug therapy, the patient underwent five sessions of PDL treatment. Ten days after the first session, the eruptions began to regress without scarring. Subsequent PDL sessions led to the complete resolution of the eruptions. The patient experienced no relapse during the follow‐up period. This case report suggests that PDL treatment may be an effective option for LMDF, particularly in cases where drug therapy has failed. Early initiation of laser treatment may prevent scarring, minimize the adverse effects associated with drug therapy, and reduce the risk of disease relapse. Further research and controlled trials are needed to establish the efficacy of laser therapy in the treatment of LMDF.
Catalytic Generation of Benzyl Anions from Aryl Ketones Utilizing [1,2]‐Phospha‐Brook Rearrangement and Their Application to Synthesis of Tertiary Benzylic Alcohols
Authors: Kondoh Azusa , Suzuki Hirochika , Hirozane Takayuki , Terada Masahiro 
Published: August 2024

AbstractA synthetic method of tertiary alcohols was developed based on the formal umpolung addition of aryl ketones with electrophiles utilizing the [1,2]‐phospha‐Brook rearrangement under Brønsted base catalysis. The addition reaction of α‐hydroxyphosphonates, derived from alkyl aryl‐ and diaryl ketones, with electrophiles such as phenyl vinyl sulfone, afforded phosphates having a tertiary alkyl group, which were readily convertible to the corresponding tertiary benzylic alcohols. This operationally simple protocol provides efficient complementary access to tertiary alcohols that are difficult to synthesize by conventional methods.
Turning Solid Waste into Catalysts: A Path for Environmental Solutions
Authors: Rautela Rahul , Sharma Apurva , Prakash Ranjan Ved , Rathika K , Pratap Vinay , Ram Yadav Bholu , Kumar Sunil 
Published: August 2024

AbstractWaste, often overlooked, stands out as a prime source of valuable products, meeting the demand for natural resources. In the face of environmental challenges, this study explores the crucial role of waste‐derived catalysts in sustainable practices, emphasizing the transformative potential of solid waste materials. Carbon‐based catalysts sourced from agricultural, municipal, and industrial waste streams can be transformed into activated carbon, biochar, and hydrochar which are extensively used adsorbents. Furthermore, the paper also highlights the potential of transition metal‐based catalysts derived from spent batteries, electronic waste, and industrial byproducts, showcasing their efficacy in environmental remediation processes. Calcium‐based catalysts originating from food waste, including seashells, eggshells, bones, as well as industrial and construction waste also find an extensive application in biodiesel production, providing a comprehensive overview of their promising role in sustainable and eco‐friendly practices. From mitigating pollutants to recovering valuable resources, waste‐derived catalysts exhibit a versatile role in addressing waste management challenges and promoting resource sustainability. By transforming waste into valuable catalysts, this study champions a paradigm shift towards a more sustainable and resource‐efficient future.
Understanding and resolving student conflicts: Perspectives and strategies in senior high schools across the Volta Region of Ghana
Authors: Amedome Sedem Nunyuia , Ilfiandra  , Suherman Uman 
Published: August 2024

AbstractThis study investigates the dynamics, sources, and resolution strategies of student conflicts in senior high schools across the Volta Region of Ghana. Despite the implementation of various conflict resolution and peer mediation programs, challenges in effectively managing student disputes remain prevalent. These conflicts often stem from interpersonal and academic tensions, exacerbated by a complex mix of socio‐cultural backgrounds, economic disparities, and personal beliefs. Our analysis reveals significant gender differences in conflict experiences and resolutions, highlighting the need for gender‐sensitive and culturally informed approaches. The study employed a quantitative research design, utilizing a structured questionnaire to gather data from a representative sample of 661 students. The findings indicate that interpersonal conflicts with peers and academic‐related issues are the most common, with conflicts involving violence and guns being comparatively rare. Gender‐specific differences were notable in responses to conflicts involving school administration and cultural or ethnic disparities. The research underscores the importance of adopting comprehensive, culturally sensitive conflict resolution programs that are tailored to the unique socio‐cultural and educational context of the Volta Region. By addressing these nuanced needs, the study aims to enhance the educational landscape and foster an atmosphere conducive to effective dispute resolution. The findings contribute to the discourse on implementing effective, culturally responsive conflict resolution mechanisms in Ghanaian senior high schools, advocating for strategies that support the holistic development of students.