bluuebunny/crossref_metadata_2025_split huggingface dataset:
Causes of false-negative sentinel node biopsy in patients with breast cancer
Authors: Andersson Y , Frisell J , Sylvan M , de Boniface J , Bergkvist L 
Published: February 2013

AbstractBackgroundSentinel lymph node (SLN) biopsy has replaced axillary lymph node dissection as the routine staging procedure in clinically node-negative breast cancer. False-negative SLN biopsy results in misclassification and may cause undertreatment of the disease. The aim of this study was to investigate whether serial sectioning of SLNs reveals metastases more frequently in patients with false-negative SLNs than in patients with true-negative SLNs.MethodsThis was a case–control study. Tissue blocks from patients with false-negative SLNs, defined as tumour-positive lymph nodes excised at completion axillary dissection or a subsequent axillary tumour recurrence, were reassessed by serial sectioning and immunohistochemical staining. For each false-negative node, two true-negative SLN biopsies were analysed. Tumour and node characteristics in patients with false-negative SLNs were compared with those in patients with a positive SLN by univariable and multivariable regression analysis.ResultsUndiagnosed SLN metastases were discovered in nine (18 per cent) of 50 patients in the false-negative group and in 12 (11.2 per cent) of 107 patients in the true-negative group (P = 0.245). The metastases were represented by isolated tumour cells in 14 of these 21 patients. The risk of a false-negative SLN was higher in patients with hormone receptor-negative (odds ratio (OR) 2.50, 95 per cent confidence interval 1.17 to 5.33) or multifocal tumours (OR 3.39, 1.71 to 6.71), or if only one SLN was identified (OR 3.57, 1.98 to 6.45).ConclusionSLN serial sectioning contributes to a higher rate of detection of SLN metastasis. The rate of upstaging of the tumour is similar in false- and true-negative groups of patients.
Conformance and Deviance: Company Responses to Institutional Pressures for Corporate Social Responsibility Reporting
Authors: Pedersen Esben Rahbek Gjerdrum , Neergaard Peter , Pedersen Janni Thusgaard , Gwozdz Wencke 
Published: February 2013

ABSTRACTThis paper analyses how large Danish companies are responding to new governmental regulation which requires them to report on corporate social responsibility (CSR). The paper is based on an analysis of 142 company annual reports required by the new Danish regulation regarding CSR reporting, plus 10 interviews with first‐time reporting companies and six interviews with companies that failed to comply with the new law. It is concluded that coercive pressures from government have an impact on CSR reporting practices. Further, the analysis finds traces of mimetic isomorphism which inspires a homogenisation in CSR reporting practices. Finally, it is argued that non‐conformance with the new regulatory requirements is not solely about conscious resistance but may also be caused by, for example, lack of awareness, resource limitations, misinterpretations, and practical difficulties. Copyright © 2013 John Wiley & Sons, Ltd and ERP Environment.
ChemInform Abstract: A Paal—Knorr Approach to 3,4‐Diaryl‐Substituted Pyrroles: Facile Synthesis of Lamellarins O and Q.
Authors: Ramirez‐Rodriguez Armando , Mendez Jose M. , Jimenez Cristina C. , Leon Fernando , Vazquez Alfredo 
Published: February 2013

AbstractA novel approach to 3,4‐bisaryl substituted pyrroles is developed using succinonitriles of type (V) as key intermediates.
Patient‐reported outcomes after 3‐dimensional conformal, intensity‐modulated, or proton beam radiotherapy for localized prostate cancer
Authors: Gray Phillip J. , Paly Jonathan J. , Yeap Beow Y. , Sanda Martin G. , Sandler Howard. M. , Michalski Jeff M. , Talcott James A. , Coen John J. , Hamstra Daniel A. , Shipley William U. , Hahn Stephen M. , Zietman Anthony L. , Bekelman Justin E. , Efstathiou Jason A. 
Published: February 2013

AbstractBACKGROUND:Recent studies have suggested differing toxicity patterns for patients with prostate cancer who receive treatment with 3‐dimensional conformal radiotherapy (3DCRT), intensity‐modulated radiotherapy (IMRT), or proton beam therapy (PBT).METHODS:The authors reviewed patient‐reported outcomes data collected prospectively using validated instruments that assessed bowel and urinary quality of life (QOL) for patients with localized prostate cancer who received 3DCRT (n = 123), IMRT (n = 153) or PBT (n = 95). Clinically meaningful differences in mean QOL scores were defined as those exceeding half the standard deviation of the baseline mean value. Changes from baseline were compared within groups at the first post‐treatment follow‐up (2‐3 months from the start of treatment) and at 12 months and 24 months.RESULTS:At the first post‐treatment follow‐up, patients who received 3DCRT and IMRT, but not those who received PBT, reported a clinically meaningful decrement in bowel QOL. At 12 months and 24 months, all 3 cohorts reported clinically meaningful decrements in bowel QOL. Patients who received IMRT reported clinically meaningful decrements in the domains of urinary irritation/obstruction and incontinence at the first post‐treatment follow‐up. At 12 months, patients who received PBT, but not those who received IMRT or 3DCRT, reported a clinically meaningful decrement in the urinary irritation/obstruction domain. At 24 months, none of the 3 cohorts reported clinically meaningful changes in urinary QOL.CONCLUSIONS:Patients who received 3DCRT, IMRT, or PBT reported distinct patterns of treatment‐related QOL. Although the timing of toxicity varied between the cohorts, patients reported similar modest QOL decrements in the bowel domain and minimal QOL decrements in the urinary domains at 24 months. Prospective randomized trials are needed to further examine these differences. Cancer 2013. © 2013 American Cancer Society.
THE RELEVANCE OF ACCURACY FOR THE IMPACT OF MACROECONOMIC NEWS ON EXCHANGE RATE VOLATILITY
Authors: LaakkOnen HelinÄ , Lanne Markku 
Published: February 2013

ABSTRACTWe study whether the accuracy of news announcements matters for the impact of news on exchange rate volatility. We use high‐frequency EUR/USD returns and releases of 20 US macroeconomic indicators and measure the precision of news in three different ways. When the precision is defined by the size of the first revision of the previous month's figure, we find that precise news increases volatility significantly more than imprecise news. Also, news on indicators that are in general more precise increase volatility more than news on typically imprecise indicators. Finally, we use real‐time data to measure the ‘true’ precision of news and find that the size of the first revision of the previous month's figure is a reasonable signal of ‘true’ precision. Copyright © 2013 John Wiley & Sons, Ltd.
Ocular‐Side Lateralization of Adult‐Type Chromatophore Precursors: Development of Pigment Asymmetry in Metamorphosing Flounder Larvae
Authors: Washio Youhei , Aritaki Masato , Fujinami Yuichiro , Shimizu Daisuke , Yokoi Hayato , Suzuki Tohru 
Published: February 2013

AbstractThe adult‐type chromatophores of flounder differentiate at metamorphosis in the skin of ocular side to establish asymmetric pigmentation. In young larva and before metamorphosis, adult‐type melanophores that migrate to the ocular side during metamorphosis reside at the base of the dorsal fin as latent precursors. However, the migration route taken by these precursor cells and the mechanisms by which lateralization and asymmetric pigmentation develop on the ocular side are unknown. To further investigate this migration and lateralization, we used in situ hybridization with gch2 probe, a marker for melanoblasts and xanthoblasts (precursors of adult type chromatophores), to examine the distribution of chromatophore precursors in metamorphosing larvae. The gch2‐positive precursors were present in the myoseptum as well as in the skin. This finding indicated that these precursors migrated from the dorsal part of the fin to the skin via the myoseptum. Additionally, there were much fewer gch2‐positive cells in the myoseptum of the blind side than in the skin and myoseptum of the ocular side, and this finding indicated either that migration of the precursor cells into the myoseptum of blind side was inhibited or that the precursors were eliminated from the myoseptum of the blind side. Therefore, we propose that the signals responsible for development of asymmetric pigmentation in flounder reside not only in the skin but on a larger scale and in multiple tissues throughout the lateral half of the trunk. J. Exp. Zool. (Mol. Dev. Evol.) 320B:151–165, 2013. © 2013 Wiley Periodicals, Inc.
Grading severity of carpal tunnel syndrome in electrodiagnostic reports: Why grading is recommended
Authors: Sucher Benjamin M. 
Published: February 2013

ABSTRACTCarpal tunnel syndrome (CTS) is not difficult to confirm by electrodiagnosis (EDx), but the challenge lies in whether to grade the severity and the method for doing so. The arguments about grading are discussed, with an emphasis in favor, using a method that relies on the EDx data, but qualifies that it is the median neuropathy being graded and not the syndrome of CTS. Although use of latencies can be arbitrary and misleading, it is possible to apply other criteria, such as low amplitudes or conduction block and denervation, to develop a grading scale that could be applied widely. Several previously published grading schemes are reviewed, and a new method is described that combines the prior ranking criteria into 3 basic categories. Application of a grading system identifies the degree of nerve injury and thus allows the referring physician to utilize optimally the EDx report to manage the patient. Muscle Nerve 48: 331–333, 2013
Room temperature operation of ITO nano‐crystal gas sensor
Authors: Koo Jieun , Park Seunghwan , Lee Woong , Cho Youngji , Lee Hyojong , Lee Sangtae , Chang Jiho 
Published: February 2013

AbstractWe proposed an indium‐tin‐oxide (ITO) based gas sensor which can operate at room temperature. ITO nano‐crystal was screen printed on a quartz substrate. To improve the sensitivity and to decrease the resistivity of the printed ITO layer, pressurized annealing was adopted. Resistivity of the printed ITO gas sensor decreased from 3.5 kΩcm to 1.56 Ωcm by pressurized annealing. We could observe room temperature operation of the printed ITO gas sensor by using various gases such as Ar, N2, O2 and CH4. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A sealed‐bid multi‐attribute auction protocol with strong bid privacy and bidder privacy
Authors: Shi Wenbo 
Published: February 2013

ABSTRACTIn this paper, a sealed‐bid multi‐attribute auction protocol that mainly focuses on security issues (i.e., bid privacy, bidder anonymity, and fairness problem) is presented. In recent years, existing literatures mainly focus on the multi‐attribute winner determination problem and other issues, but research of multi‐attribute e‐auction just begin from the perspective of information security. The new proposal is motivated by the conflict between bidder anonymity and denial‐of‐service attack from an insider. It utilizes private set intersection method to solve the privacy problem of winner determination of sealed‐bid multi‐attribute auction. The proposed sealed‐bid auction scheme preserves the strong privacy of the bids and provides verifiable correctness. According to the security analysis, it satisfies the security requirements of an e‐auction. Copyright © 2013 John Wiley & Sons, Ltd.
Adherence Support Approaches in Biomedical HIV Prevention Trials: Experiences, Insights and Future Directions from Four Multisite Prevention Trials
Authors: Amico K. Rivet , Mansoor Leila E. , Corneli Amy , Torjesen Kristine , van der Straten Ariane 
Published: February 2013

Abstract
Adherence is a critical component of the success of antiretroviral-based pre-exposure prophylaxis (PrEP) in averting new HIV-infections. Ensuring drug availability at the time of potential HIV exposure relies on self-directed product use. A deeper understanding of how to best support sustained PrEP adherence remains critical to current and future PrEP efforts. This paper provides a succinct synthesis of the adherence support experiences from four pivotal PrEP trials—Centre for the AIDS Programme of Research in South Africa (CAPRISA) 004, FEM-PrEP, Iniciativa Prophylaxis (iPrEx), and Vaginal and Oral Interventions to Control the Epidemic (VOICE). Notwithstanding variability in the design, population/cohort, formulation, drug, dosing strategy, and operationalization of adherence approaches utilized in each trial, the theoretical basis and experiences in implementation and monitoring of the approaches used by these trials provide key lessons for optimizing adherence in future research and programmatic scale-up of PrEP. Recommendations from across these trials include participant-centered approaches, separating measurement of adherence from adherence counseling, incorporating tailored strategies that go beyond education, fostering motivation, and addressing the specific context in which an individual incorporates and negotiates PrEP use.
Sociodemographic, lifestyle and dietary correlates of dietary supplement use in a large sample of French adults: results from the NutriNet-Santé cohort study
Authors: Pouchieu Camille , Andreeva Valentina A. , Péneau Sandrine , Kesse-Guyot Emmanuelle , Lassale Camille , Hercberg Serge , Touvier Mathilde 
Published: February 2013

Information on the determinants of dietary supplement (DS) use in France is largely lacking, especially in population subgroups such as smokers. Also, little is known about the role of health professionals in DS purchases. The aim of the present study was to describe DS use along with its sociodemographic, lifestyle and dietary correlates in a large sample of French adults (age 18+years) participating in the NutriNet-Santé cohort study. Data were collected by self-administered Internet questionnaires. Food intakes were assessed by 24 h dietary records. Data on DS use were available for 79 786 participants. Supplement users were compared with non-users by logistic regression. Current DS use at least three times/week was reported by 14·6 % of men and 28·1 % of women. Mg, and vitamins B6 and C were the most frequently consumed nutrients. DS were prescribed or recommended by a physician in 54·9 % of the cases. DS use was positively associated with knowledge of nutritional recommendations and organic product consumption, following a healthier diet and lifestyle (non-smoker, moderate leisure-time physical activity). Current smokers used less DS than did non-smokers, but their DS consumption was substantial (19·0 %) and they were more likely to self-medicate. The present study provides updated and detailed information on DS use determinants in a large French cohort, including a focus on smokers, for whom the long-term effects of DS use are poorly documented and could represent a risk. These findings pave the way for future aetiological studies.
Use of Human-Altered Habitats by Bull Sharks in a Florida Nursery Area
Authors: Curtis Tobey H. , Parkyn Daryl C. , Burgess George H. 
Published: February 2013

Abstract
Bull Sharks Carcharhinus leucas in the Indian River Lagoon, Florida, have been documented to frequently occur in human-altered habitats, including dredged creeks and channels, boat marinas, and power plant outfalls. The purpose of this study was to examine the short-term movements of age-0 and juvenile Bull Sharks to quantify the extent to which those movements occur in altered habitats. A total of 16 short-term active acoustic tracks (2–26 h) were carried out with 9 individuals, and a 10th individual was fitted with a long-term coded transmitter for passive monitoring by fixed listening stations. Movement and activity space statistics indicated high levels of area reuse over the span of tracking (hours to days). All but one shark used
altered habitat at some point during tracking, such that 51% of all tracking positions occurred in some type of altered habitat. Of the sharks that used altered habitat, the mean (±1 SD) percent of positions within altered habitat was 66 (±40)%. Furthermore, tracks for 3 individuals indicated selection for altered habitats. The single passively monitored Bull Shark was detected in power plant outfalls almost daily over a 5-month period, providing the first indication of longer-term fidelity to thermal effluents. Use of one dredged creek was influenced by local salinity, the tracked sharks dispersing from the altered habitat when salinity declined. The affinity of young Bull Sharks to altered habitats in this system could help explain their reported accumulation of a variety of harmful contaminants, which could negatively affect their health and survival.
Received July 27, 2012; accepted November 28, 2012
EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments
Authors: Leng Ning , Dawson John A. , Thomson James A. , Ruotti Victor , Rissman Anna I. , Smits Bart M. G. , Haag Jill D. , Gould Michael N. , Stewart Ron M. , Kendziorski Christina 
Published: February 2013

AbstractMotivation: Messenger RNA expression is important in normal development and differentiation, as well as in manifestation of disease. RNA-seq experiments allow for the identification of differentially expressed (DE) genes and their corresponding isoforms on a genome-wide scale. However, statistical methods are required to ensure that accurate identifications are made. A number of methods exist for identifying DE genes, but far fewer are available for identifying DE isoforms. When isoform DE is of interest, investigators often apply gene-level (count-based) methods directly to estimates of isoform counts. Doing so is not recommended. In short, estimating isoform expression is relatively straightforward for some groups of isoforms, but more challenging for others. This results in estimation uncertainty that varies across isoform groups. Count-based methods were not designed to accommodate this varying uncertainty, and consequently, application of them for isoform inference results in reduced power for some classes of isoforms and increased false discoveries for others.Results: Taking advantage of the merits of empirical Bayesian methods, we have developed EBSeq for identifying DE isoforms in an RNA-seq experiment comparing two or more biological conditions. Results demonstrate substantially improved power and performance of EBSeq for identifying DE isoforms. EBSeq also proves to be a robust approach for identifying DE genes.Availability and implementation: An R package containing examples and sample datasets is available at http://www.biostat.wisc.edu/∼kendzior/EBSEQ/.Contact: kendzior@biostat.wisc.eduSupplementary information: Supplementary data are available at Bioinformatics online.
Talaya batraba gen. et sp. nov. – the First Nymph of a Protopsyllidiid (Hemiptera: Sternorrhyncha: Psyllomorpha) from the Lower Cretaceous Amber of Lebanon
Authors: DROHOJOWSKA Jowita , SZWEDO Jacek , AZAR Dany 
Published: February 2013

AbstractA hemipteran nymph of the sternorrhynchan lineage, placed in the family Protopsyllidiidae is the first found in the fossil record, based on an inclusion in amber from the Lower Cretaceous of Hammana / Mdeyrij, Abeih Formation, Central Lebanon. Based on distinctive features such as a median dorsal elevation and the presence of a large, conical, exposed, setiferous anal tube, the fossil is placed in Talaya batraba gen. et sp. nov. and the newly erected taxon is compared to known nymphs of extinct Protopsyllidiidae. The evolutionary traits of the family and its relatives are considered.
The Ore‐forming Mechanism of the Jiajika Pegmatite‐Type Rare Metal Deposit in Western Sichuan Province: Evidence from Isotope Dating
Authors: Jiankang LI , Denghong WANG , Yuchuan CHEN 
Published: February 2013

AbstractGranitic pegmatites are commonly thought to form by fractional crystallization or by liquid immiscibility of granitic magma; however, these proposals are based mainly on analyses of fluid and melt inclusions. Here, we use the Jiajika pegmatite deposit, the largest spodumene deposit in Asia, as a case study to investigate ore forming processes using isotope dating. Daring of a single granite sample from the Jiajika deposit using multiple methods gave a zircon U–Pb SHRIMP age of 208.4 ± 3.9 Ma, an 40Ar/39Ar age for muscovite of 182.9 ± 1.7 Ma, and an 40Ar/39Ar age for biotite of 169.9 ± 1.6 Ma. Based on these dating results and the 40Ar/39Ar age of muscovite from the Jiajika pegmatite, a temperature–time cooling track for the Jiajika granite was constructed using closure temperatures of the different isotope systems. This track indicates that the granite cooled over ∼40 m. y., with segregation of the pegmatite fluid from the granitic magma at a temperature of ∼700°C. This result suggests that the Jiajika pegmatite formed not by fractional crystallization, but by segregation of an immiscible liquid from the granitic magma. When compared with fractional crystallization, the relatively early timing of segregation of an immiscible liquid from a granitic magma can prevent the precipitation of ore‐forming elements during crystallization, and suggests that liquid immiscibility could be an important ore‐forming process for rare metal pegmatities. We also conclude that isotope dating is a method that can potentially be used to determine the dominant ore‐forming processes that occurred during the formation of granite‐related ore deposits, and suggest that this method can be employed to determine the formation history of the W–Sn ore deposits found elsewhere within the Nanling Metallogenic Belt.
Long‐term treatment with romiplostim in patients with chronic immune thrombocytopenia: safety and efficacy
Authors: Kuter David J. , Bussel James B. , Newland Adrian , Baker Ross I. , Lyons Roger M. , Wasser Jeffrey , Viallard Jean‐Francois , Macik Gail , Rummel Mathias , Nie Kun , Jun Susie 
Published: February 2013

SummaryRomiplostim was effective, safe, and well‐tolerated over 6–12 months of continuous treatment in Phase 3 trials in patients with immune thrombocytopenia (ITP). This report describes up to 5 years of weekly treatment with romiplostim in 292 adult ITP patients in a long‐term, single‐arm, open‐label study. Outcome measures included adverse events (including bleeding, thrombosis, malignancy, and reticulin/fibrosis), platelet response (platelet count >50 × 109 per litre), and the proportion of patients requiring rescue treatments. Treatment–related serious adverse events were infrequent and did not increase with longer treatment. No new classes of adverse events emerged. Thrombotic events occurred in 6·5% of patients and were not associated with platelet count. Median platelet counts of 50–200 × 109 per litre were maintained with stable doses of romiplostim (mean 5–8 μg/kg; generally self‐administered at home) throughout the study. A platelet response was achieved at least once by 95% of patients, with a platelet response maintained by all patients on a median 92% of study visits. There was a low rate of bleeding and infrequent need for rescue treatments. In conclusion, this study demonstrated that romiplostim was safe and well‐tolerated over 614 patient‐years of exposure in ITP patients, and that efficacy was maintained with stable dosing for up to 5 years of continuous treatment.