bluuebunny/crossref_metadata_2025_split huggingface dataset:
Platelet-rich Plasma versus Corticosteroid Injection for the Treatment of Lateral Epicondylitis – A Prospective Randomised Controlled Study
Authors: Kalluraya Suryakanth , Varma Anand , Yeswanth Gujjala Venkata Naga 
Published: August 2024

Abstract

Introduction:
Lateral epicondylitis, commonly known as tennis elbow, is one of the most common chronic disabling painful conditions that affect the forearm’s common extensor tendons. This study aimed to compare the effectiveness of platelet-rich plasma (PRP) versus corticosteroid injection in the treatment of lateral epicondylitis.

Aims:
The purpose of this study is to compare the efficacy of PRP versus corticosteroid injection in the treatment of lateral epicondylitis, focusing on the early response.

Settings and Design:
This was a prospective randomised controlled study.

Materials and Methods:
This study was a prospective randomised control trial of 100 patients, clinically diagnosed with lateral epicondylitis in Karnataka Institute of Medical Sciences Hospital, Hubli. Patients were randomly allocated (1:1) using computer-generated random numbers to two groups. Group A received corticosteroid injection. Group B received PRP injection. Outcome assessment was done using the Oxford Elbow Score (OES), Visual Analogue Scale (VAS), Patient-rated Tennis Elbow Evaluation (PRTEE) and Disabilities of Arm, Shoulder and Hand Score (DASH). All patients were followed up at regular intervals of 2 weeks, 4 weeks, 3 months and 6 months post-injection.

Statistical Analysis Used:
Using SPSS Statistics version 25 software, statistical analysis was done.

Results:
Pre–injection, the mean OES, VAS, PRTEE and DASH scores were similar in both the groups with insignificant P value. The mean pre-injection OES, VAS, PRTEE and DASH scores in the corticosteroid group were 11.22, 7.88, 75.950 and 69.364, whereas in the PRP group, it was 10.66, 7.96, 76.170 and 69.466, with P = 0.165, 0.322, 0.834 and 0.869, respectively. At the end of 6 months in the corticosteroid group, the mean score of OES increased from 11.22 ± 1.71 to 38.94 ± 5.17, VAS decreased from 7.88 ± 0.385 to 1.74 ± 1.24, PRTEE decreased from 75.95 ± 4.86 to 24.3 ± 12 and DASH decreased from 69.36 ± 2.90 to 23.31 ± 11.5, with a significant P < 0.005. At the end of 6 months in the PRP group, the mean scores of OES increased from 10.66 ± 2.07 to 45.38 ± 1.41, VAS decreased from 7.96 ± 0.45 to 0.06 ± 0.31, PRTEE decreased from 76.1 ± 5.04 to 7.47 ± 3.16 and DASH decreased from 69.47 ± 3.44 to 7.78 ± 2.65, with a significant P < 0.005.

Conclusion:
We concluded that patients treated with PRP had significantly reduced pain, increased functional activity, less recurrence and without requirement of any further intervention, outperforming corticosteroid injection effect at the end of 6 months follow up.
Post-surgical Rehabilitation Protocol and Outcome in Tendoachilles Rupture with Large Defect: A Case Series
Authors: Biswas Anurug , Pandey Sanjay Kumar , Kumar Anjani , Kumar Sanyal , Pandey Jyoti , Roy Madhumita Singha 
Published: August 2024

Abstract
Achilles tendon (AT) is the strongest and one of the commonly ruptured tendons. For AT rupture with large defect, surgery is arguably better option than conservative one. However, rehabilitation protocol and outcome after surgery for AT rupture with larger defects is not mentioned well in the literature. In this series, 11 cases of AT rupture with large defect are studied retrospectively from the hospital records. All of the cases received uniform structured rehabilitation and orthotic management following repair surgery and were followed up at 6 months and 1 year. Significant improvement in pain, function and strength was noted and temporal association is found between symptomatic change and day of presentation. However, there was no report of re-rupture and there was no difference in outcome with intraoperative platelet-rich plasma injection.
Impact of socio-vocational rehabilitation on work productivity and social behavior of inpatients with chronic schizophrenia
Authors: Kumari Sushma , Chakraborty Prashanta K. 
Published: August 2024

Background:
A large proportion of persons with schizophrenia are either abandoned by their family members in mental hospitals or do not have any family members to look after them. Therefore, almost 2/3rd of hospital beds are occupied by chronic schizophrenic patients. Very few beds are available for the treatment of acute mental patients who need urgent hospitalization.

Aim:
To assess the impact of a comprehensive socio-vocation rehabilitation package on the work productivity and social behavior of persons with chronic schizophrenia.

Materials and Methods:
Sixty chronic schizophrenic inpatients were included in the present study. Sociodemographic and clinical details were collected on a specially designed Performa for the study. Each patient was rated on a job-up-to-date form at baseline, 3 months, and 6 months after intervention. Data related to the vocational outcome were collected on the supervisor’s evaluation form at the end of the first month and then after every month till the end of 6 months after intervention. The patient’s social behavior was measured on the Social Behavior Schedule at baseline, 3 months, and 6 months after intervention.

Results:
Significant improvement was found in the area of vocational outcomes when a comparison was made from the 1st month to the 6th month. Marked improvement was also noticed in their social behaviors after social and vocational rehabilitation.

Conclusion:
The overall results suggest that chronic schizophrenic inpatients can be properly rehabilitated if opportunity is provided to them.
Raising a child with cancer: Impact on parents’ health-related quality of life
Authors: Zeeshan Mohammad , Singh Krishna Kumar , Sinha Niska , Madhawi Richa , Zubair Mohd. Yasir , Kumar Santosh 
Published: August 2024

Background:
Having a child with a serious illness like cancer has a detrimental and negative impact on the parents’ health-related quality of life (HRQOL). Many factors have been identified as being associated with poorer HRQOL. Acquiring knowledge about these factors is essential to enhancing the quality of life (QOL) of children as well as their parents.

Aim:
This study aims to analyze HRQOL in parents of children with cancer and to explore relationships between parent and child variables and parental quality of life.

Materials and Methods:
A total of 80 parents of children with cancer were enrolled in this cross-sectional study. To evaluate the parental HRQOL, the Short Form 36 Health Survey Questionnaire (SF-36) was used.

Results:
Child age and time since diagnosis showed a positive correlation with all domains of HRQOL on Spearman’s correlation. A statistically significant difference in SF-36 scores across four cancer groups was seen on the Kruskal–Wallis test. Mothers showed poorer quality of life in the physical role functioning domain as compared to fathers (U = 248, P < 0.01).

Conclusion:
The present study shows poor HRQOL for parents of children with cancer, despite learning to cope and adjust over time. Parents of children with retinoblastoma demonstrate a poorer QOL as compared to other cancer groups. The study suggests close monitoring of parents’ QOL and the provision of appropriate treatment and psychosocial support for parents along with the treatment of children.
Relation of Supraventricular Arrhythmias Detected by Implantable Cardioverter Defibrillator and Air Pollutants
Authors: Shahabi Javad , Azhari Amirhossein , Rahimi-Pordanjani Amin , Safari Mohsen 
Published: August 2024

Introduction:
One of the therapeutic approaches in cases with high-risk heart disease, particularly heart failure, is the implantation of an implantable cardioverter defibrillator (ICD) to avoid unexpected death. Supraventricular arrhythmias (SVAs) are one of the most common events in aforementioned subjects and it has been proposed that air pollution plays a substantial role in deteriorating of condition.

Materials and Methods:
The present investigation was performed from April 2018 to March 2019 in Chamran Hospital of Medical University of Isfahan, Isfahan, Iran on the 100 cases who had ICD and lived in Isfahan. We recorded the residence of participants to be matched to the reports of the Isfahan Meteorological Organization, and then comprehensive valuations associated with SVAs were done in them.

Results:
There was no significant difference between age and sex with the incidence of SVAs (P = 0.15 and 0.57, respectively). There is no significant difference between the presence of comorbidities and the incidence of SVAs (P = 0.57). The relationship between SVA and air pollution was significant (P = 0.008). Furthermore, based on the correlation test results, the aforementioned relationship was significant with a Spearman correlation coefficient of 0.29 and P = 0.003.

Conclusion:
The severity of air pollution is associated with an increase in SVAs in patients with ICD. In the present study, due to the insignificance of confounding variables such as smoking and diabetes, it is largely reliable, but what is certain to make a definite statement about this relationship, is conduct a study with a larger sample size and also in several centers is necessary.
Impact of Non-surgical Periodontal Therapy on Oral Health-related Quality of Life amongst Primary Dental Care Patients: A Prospective Cohort Study
Authors: Planisamy Vanaja , Yin Ee Ai 
Published: August 2024

Abstract

Aim:
The aim of this study was to determine the impact of non-surgical periodontal therapy (NSPT) on oral health-related quality of life (OHRQoL) of a selected group of the Malaysian population at the primary dental care setting.

Participants and Methods:
This study was conducted from year 2021 to 2022. Patients attending four government dental clinics in Kinta district were included in the study after basic periodontal examination was conducted. The sample size was calculated using the NCSS PASS 11 power analysis and sample size, and a final sample size of 94 was used. A short version of the Malaysian Oral Health Impact Profile (S-OHIP[M]) questionnaire was given as a baseline before the intervention. NSPT was provided in a single session or by a quadrant approach. Patients were then called for review after 6 weeks during when they were required to complete the S-OHIP(M) questionnaire again. All data were then entered and analysed using SPSS version 26.0.

Results:
The prevalence of impact decreased significantly post-treatment (n [%] pre vs. post: 91 [96.8%] vs. 70 [74.5%]; P < 0.001). A significant decrease was observed in the severity of impact (additive score) (median [interquartile range (IQR)] pre vs. post: 8.5 [5.0–15.0] vs. 2.0 [0.0–6.0]; P < 0.001) and extend of impact (simple count score) (median [IQR] pre vs. post: 0.5 [0.0–2.0] vs. 0.0 [0.0–0.0]; P < 0.001) post-treatment compared to pre-treatment too.

Conclusion:
The OHRQoL status amongst gingivitis and mild-to-moderate periodontitis patients in primary care has improved after treatment.
On irreducible representations of Fuchsian groups
Authors: Balaji Vikraman , Pandey Yashonidhi 
Published: August 2024

AbstractLet
${\mathcal {R}} \subset \mathbb {P}^1_{\mathbb {C}}$
be a finite subset of markings. Let G be an almost simple simply-connected algebraic group over
$\mathbb {C}$
. Let
$K_G$
denote the compact real form of G. Suppose for each lasso l around the marked point, a conjugacy class
$C_l$
in
$K_G$
is prescribed. The aim of this paper is to give verifiable criteria for the existence of an irreducible homomorphism of
$\pi _{1}(\mathbb P^1_{\mathbb {C}} \,{\backslash}\, {\mathcal {R}})$
into
$K_G$
such that the image of l lies in
$C_l$
.
Domperidone and sudden cardiac death in the elderly due to ventricular arrhythmias in developing countries
Authors: Azeen Razzaq  , Shafaq Saleem  , Hassan Javed  
Published: August 2024

To the Editor,
Domperidone is a prokinetic drug used to treat many gastrointestinal conditions including delayed gastric emptying and gastroesophageal reflux disease due to its promotility effects by antagonism on dopamine-2 receptors in the gut. It has also been used as an over-the-counter drug for nausea and vomiting due to its direct action on the chemoreceptor trigger zone involved in vomiting. The drug has gained a lot of popularity as it is more effective than other prokinetic drugs like mosapride and metoclopramide. In addition, it causes less drowsiness than metoclopramide and mosapride because it does not readily cross the blood-brain barrier(1). However, this drug has many side effects including dry mouth, headache and weight gain(2). Despite this, domperidone has been used as a prokinetic in many countries for a long time.
However, the more critical concern about the use of domperidone is QT interval prolongation and its association with sudden cardiac death due to ventricular arrhythmias in patients aged 50 years and older and in those taking more than 30mg/day. A meta-analysis conducted in November 2018 by Bor et al. compared the odds of developing cardiovascular events like sudden cardiac death in patients aged >50 taking domperidone more than 30mg/day to patients not taking domperidone or any other drugs was consistent with statistically significant increased risk of sudden cardiac deaths due to ventricular arrhythmias (OR: 2.09, 95% CI, 1.59 to 2.75, p<0.001)(3).
These are not the only studies to show these results. Many other studies have been done so far which showed an association between domperidone usage and sudden cardiac deaths in the elderly. A systematic review published in 2021 pooled data across multiple studies and showed that domperidone was significantly associated with an increased risk of sudden cardiac death and ventricular arrhythmias in older patients when taken more than 30mg/day. In this meta-analysis when data were pooled across nonoverlapping multiple studies, domperidone was associated with an increased risk of sudden cardiac death in the elderly compared to non-use (adjusted odds ratio: 1.69(1.46-1.95)(4). As far as the young population is concerned, there are very few studies done, so more research needs to be done to find out if domperidone causes sudden cardiac death in young patients.
Despite all these concerns, this drug is still being prescribed in many developing countries, especially in Pakistan.
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ROLE OF HIGH-TEMPERATURE PROTEIN G IN THE VIRULENCE AND DEVELOPMENT OF ANTIMICROBIAL RESISTANCE IN SOME ORAL BACTERIAL ISOLATES
Authors: Patki Jyoti M , Purohit Shruti 
Published: August 2024

A marked increase in antimicrobial resistance among common bacterial pathogens has made the search for new therapeutic targets highly imperative. The present study was aimed to analyse the potential of bacterial chaperone high-temperature protein G (HtpG) as a therapeutic target by determining its role in virulence and antibiotic resistance. Two bacterial isolates obtained from the oral cavity of healthy human subjects were characterized and tentatively identified as Staphylococcus aureus and Streptococcus mutans. Survival assays of these isolates showed induction of thermotolerance with around 24% increase in survival at lethal temperature after preconditioning. Protein profile studies revealed prominent expression of proteins of 99, 77 and 40 kDa in thermo tolerance group as compared to the control. HtpG inhibition was achieved by using a pharmacological inhibitor of human Hsp90, geldanamycin (GA). In disc diffusion assays, there was no significant inhibitory impact of HtpG on antibiotic susceptibility to six antimicrobial compounds in both the isolates as compared to the control. An 18-19% reduction in biofilm-forming capacity was observed for both isolates after GA treatment. This study lays strong experimental evidence to the involvement of HtpG in the development of anti-microbial resistance through biofilm formation.
FUNCTIONAL METATRANSCRIPTOMICS REVEALS A NOVEL MULTI METAL TOLERANT GENE OF NRAMP-FAMILY, ISOLATED FROM METAL-CONTAMINATED SOIL
Authors: Yadav Bhupendra Narayan Singh , Sharma Priyanka , Maurya Shristy , Yadav Rajiv Kumar 
Published: August 2024

The continuous release of heavy metal pollutants into soil through human activities posesthreat to both macro- and micro-organisms within the ecosystem. Functional metatranscriptomics is a robust method for discovering novel genes associated with a particular biological process. In this study, functional meta transcriptomic approach was employed to isolate a gene from size-fractionated cDNA libraries of micro-eukaryotes. The cDNA libraries were raised using high-quality RNA from heavy metal-contaminated soil. The identified gene aligned with Nramp (Natural resistance associated macrophage protein) family. The gene, JMC-10, was submitted to GenBank under Accession No. OR882126, and it encodes a protein with high sequence similarity to other Nramp family members, including Smf1p, Smf2p, and Smf3p in Saccharomyces cerevisiae. To study the function of JMC-10 gene, a series of growth assays were conducted in yeast cells that either overexpressed JMC-10 or carried a deletion of gene. The study revealed the putative role of JMC-10 in the transportation of divalent metal ions, including iron, manganese, zinc and cadmium. Notably, the overexpression of JMC-10 was induced by exposure to toxic levels of cadmium, suggesting it’s potential role in metal detoxification. The study provides new intuitions into the roles of Nramp family in metal homeostasis and highlights the potentiality of functional metatranscriptomics for identifying new genes having crucial roles in complex biological processes. Further, it may serve as a biomarker for identifying metal pollution.
PREDICTIVE MODELLING FOR SUGARCANE PRODUCTION: A COMPREHENSIVE COMPARISON OF ARIMA AND MACHINE LEARNING ALGORITHMS
Authors: Vishwajeet Singh  , Verma Med Ram , Yadav Subhash Kumar 
Published: August 2024

Accurate prediction of sugarcane yield is essential for trade, economic planning, and sustainable agriculture in India. This study addressed the challenge of forecasting sugarcane yield by evaluating the effectiveness of time series modelling and machine learning algorithms. Leveraging data spanning from 2001 to 2020, the research focuses on predicting the sugarcane yield for the subsequent years. The problem statement revolves around the need for precise yield predictions to inform decision-making in the agricultural sector. Methods employed included the utilization of Autoregressive Integrated Moving Average (ARIMA) for time series analysis and machine learning algorithms such as Random Forest (RF), Support Vector Machine (SVM), and Gradient Boosting Machine (GBM). The analysis encompassed sugarcane yield data spanning multiple years, with predictions extending for a specified duration. Through analysis of temporal patterns and dependencies within the sugarcane yield time series data using Autocorrelation Function (ACF) and Partial Autocorrelation Function (PACF), the study optimized the predictive models. Results indicated that ARIMA outperformed machine learning algorithms, exhibiting superior performance with a root meansquare error of 36700.68 anda minimumAICvalue of 456.7. The study emphasizes the significance of accurate yield predictions for agricultural planning and decision-making, highlighting the implications for sustainable crop management and the fortification of Indian sugar industry.The study affirms the importance of informed decisions facilitated by accurate yield predictions in resilient agricultural sector. Overall, this study contributes to the advancement of sugarcane yield prediction, offers practical insights for stakeholders and policymakers in India's agricultural landscape.
BIODIVERSITY OF THE GUT MICROBIOTA OF Epilachna vigintioctopunctata USING ILLUMINA MiSEQ PLATFORM
Authors: Sampath Varna , Shivashankar M , Rangeshwaran R 
Published: August 2024

The insect gut is a complex system colonized by a consortium of microbes whichshare a symbiotic relation with the host and also contribute to its growth, development, immunity and defense against its enemies, reproduction and speciation, thereby play a crucial role in its survival. Hence understanding the role of these bacteria is a crucial step for using them in microbial control of pests. In present study, a 16S microbiome profiling of gut of Epilachna vigintioctopunctata was carried out. The study revealed 553 operational taxonomic units (OTUs). The majority of bacterial OTUs belonged to the phylum Proteobacteria, followed by Bacteroidetes, Firmicutes and Actinobacteria. The majority of bacterial OTUs belonged to the family Halomonadaceae which was the most abundant taxa in larval gut. The study provides a baseline information on gut inhabiting microbes of E. vigintiocto punctata up to the genus level for most phyla.
WATER QUALITY ASSESSMENT AND STATUS OF PHYTO- AND ZOO PLANKTON OF HIMALAYAN BHAGIRATHI RIVER IN UTTARKASHI, UTTARAKHAND (INDIA)
Authors: Tiwari Mahidhar Prasad , Tiwari Poonam 
Published: August 2024

Rivers are important source of fresh water which is important for the sustenance and welfare of the society. The present study deals with the assessment of water quality parameters and with the population of phyto- and zoo-plankton of Himalayan Bhagirathi river in Uttarkashi, Uttarakhand (India). The samples were collected from the study area during summer, monsoon, and winter seasons for water quality and phyto- and zoo-plankton analysis. The air temperature, depth temperature, pH, total alkalinity, total dissolved solids (TDS), dissolved oxygen (DO), turbidity, free CO2, electric conductivity (EC), biological oxygen demand (BOD) and total hardness were determined. The study revealed that DO was maximum in winter (12.35 ± 0.25 mg L-1) and minimum in June to September (9.75 ± 0.25 mg L-1). The Bhagirathi water contained maximum DO in colder month, followed by a gradual decrease to its lowest value during June to September. BOD, an important indicator of pollution status of a water body, was high during summer perhaps due to low discharge at river. BOD was high in monsoon (4.4 ± 0.14 mg L-1) and low in winter (1.5 ± 0.14 mg L-1). The study revealed low river flow during winter. Bacillariophyceae was maximum (442 units L-1) in February and minimum (18 units L-1) in July. Chlorophyceae was maximum (80 units L-1) in January and minimum (6 units L-1) in August, while Myxophyceaewas maximum (34 units L-1) in February and minimum in June and Xanthophyceae was not recorded at this site. The maximum number of zooplankton genera was observed during winter and minimum in rainy season. The study showed that there is an urgent need to have proper water management in rainy and summer seasons so as to restore the water quality of this river.