bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cyclosporine A in children with ABCA3 deficiency
Authors: Yang Xiaohua , Forstner Maria_E. , Rothenaigner Ina , Bullo Marina , Şismanlar Tugba E. , Aslan Ayse T. , Latzin Philipp , Hadian Kamyar , Griese Matthias 
Published: July 2024

AbstractBackgroundBiallelic ATP‐binding cassette subfamily A member 3 (ABCA3) variants can cause interstitial lung disease in children and adults, for which no proven treatments exist. Recent in vitro evidence suggested that cyclosporine A (CsA) could correct some ABCA3 variants, however for other variants this is unknown and no data in patients exist.MethodsWe retrieved the clinical data of two children aged 2 and 4 years carrying homozygous ABCA3 variants (G210C and Q1045R, respectively) and empiric CsA treatment from the Kids Lung Register database. In vitro experiments functionally characterized the two variants and explored the effects of CsA alone or combined with hydroxychloroquine (HCQ) in a human alveolar epithelial cell line (A549) derived from adenocarcinoma cells.ResultsSix weeks following the introduction of CsA, both children required a reduced O2 flow supply, which then remained stable on CsA. Later, when CsA was discontinued, the clinical status of the children remained unchanged. Of note, the children simultaneously received prednisolone, azithromycin, and HCQ. In vitro, both ABCA3 variants demonstrated defective lysosomal colocalization and impaired ABCA3+ vesicle size, with proteolytic cleavage impairment only in Q1045R. CsA alone corrected the trafficking impairment and ABCA3+ vesicle size of both variants with a variant‐specific effect on phosphatidylcholine recycling in G210C. CsA combined with HCQ were additive for improving trafficking of ABCA3 in G210C, but not in Q1045R.ConclusionsCsA treatment might be helpful for certain patients with ABCA3 deficiency, however, currently strong clinical supporting evidence is lacking. Appropriate trials are necessary to overcome this unmet need.
Myzus persicae resistance to neonicotinoids—unravelling the contribution of different mechanisms to phenotype
Authors: Mottet Claire , Caddoux Laëtitia , Fontaine Séverine , Plantamp Christophe , Bass Chris , Barrès Benoît 
Published: July 2024

AbstractBackgroundDeciphering the mechanisms underlying insecticide resistance is key to devising appropriate strategies against this economically important trait. Myzus persicae, the green peach‐potato aphid, is a major pest that has evolved resistance to many insecticide classes, including neonicotinoids. M. persicae resistance to neonicotinoids has previously been shown to result from two main mechanisms: metabolic resistance resulting from P450 overexpression and a targetsite mutation, R81T. However, their respective contribution to resistant phenotypes remains unclear.ResultsBy combining extensive insecticide bioassays with and without addition of the synergist PBO, and gene copy number and expression quantification of two key P450 enzymes (CYP6CY3 and CYP6CY4) in a 23 clone collection, we, (i) confirmed that metabolic resistance is correlated with P450 expression level, up to a threshold, (ii) demonstrated that the R81T mutation, in the homozygous state and in combination with P450 overexpression, leads to high levels of resistance to neonicotinoids, and, (iii) showed that there is a synergistic interaction between the P450 and R81T mechanisms, and that this interaction has the strongest impact on the strength of resistance phenotypes. However, even though the R81T mutation has a great effect on the resistance phenotype, different R81T genotypes can exhibit variation in the level of resistance, explained only partially by P450 overexpression.ConclusionTo comprehend resistance phenotypes, it is important to take into account every mechanism at play, as well as the way these mechanisms interact. © 2024 The Author(s). Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.
Integration versus prioritization in the Sustainable Development Goals: An argument to prioritize environmental sustainability and a just transition
Authors: Elder Mark 
Published: July 2024

AbstractThis paper explores a key implementation issue for the Sustainable Development Goals (SDGs) – whether to use integrated approaches or prioritize some goals. The scientific community generally recommends integrated approaches but has little clear guidance on concrete implementation. This paper reaches two main conclusions. First, environmental sustainability needs to be prioritized. This is the inescapable logic of Earth system boundaries and related concepts. Second, environmental sustainability measures need to be based on a just transition in order to secure political support for environmental prioritization; especially, they need to provide good jobs and decent work, and they need to appear concrete and feasible. These principles should inform SDG implementation and discussions on the post‐2030 sustainable development agenda. Many existing proposals for environmental solutions stop short of recommending their prioritization; they also acknowledge the need for both social sustainability and a just transition, but these elements are usually not very concrete, especially regarding job creation. Thus, making environmental sustainability measures more economically and socially sustainable also should be prioritized.
How does globalisation affect informality in sub‐Saharan African countries?
Authors: Simatele Munacinga , Bolarinwa Segun Thompson 
Published: July 2024

AbstractThis paper examines the intricate informality‐globalisation nexus in the sub‐Saharan African context using 30 African countries. Using the Method of Moments Quantile Regression approach (MM‐QR), this study analyses the nexus using three measures of globalisation: overall, economic and trade globalisation. Furthermore, the mediating role of institutional quality is explored using five dimensions of institutional quality. The empirical results confirm a negative relationship across different measures of globalisation and different quantiles, signifying that increased globalisation tends to suppress informal economic activities. Moreover, the interactive models of globalisation and institutional quality also validate the negative relationship in the nexus. The investigation into the dimensions of institutional quality underscores their importance in shaping informality dynamics. The ‘law and order’ dimension demonstrates a notable role in reducing informality, emphasising the significance of robust legal frameworks and effective governance structures in fostering formal economic activities. Simultaneously, the adverse impact of corruption on informality highlights the need for concerted efforts to combat corruption for the sake of encouraging formalisation and economic development. By utilising the Method of Moments Quantile Regression method, this paper offers a nuanced perspective that considers variations across different segments of the informality distribution. This approach enhances our understanding of the heterogeneity in the effects of globalisation and institutions on informality within the African context. In conclusion, this paper advances the discourse on the informality‐globalisation nexus by incorporating the mediating influence of institutional quality. The findings underscore the multifaceted nature of the relationship and emphasise the need for holistic policy interventions that address both globalisation and institutional dimensions. By shedding light on the intricate web of factors impacting informality, this study provides a foundation for evidence‐based strategies aimed at sustainable economic development and inclusive growth across African nations.
A Fluorescent Probe Derived from L‐Tryptophan for Copper (II) Ion Detection in Aqueous Media
Authors: Jeevika A. , Sarika R. , Sumithra devi A. 
Published: July 2024

AbstractCopper (Cu2+) is a transition metal ion extensively distributed in numerous foodstuffs of both animals and vegetables. An excess intake of Cu2+ ions cause injury, pneumonitis, a disorder in the nervous system, and gastrointestinal problems. Hence, we have developed a simple and novel Schiff base‐based fluorescence sensor for the detection of Cu2+ ions. The sensor, ‐3‐(1H‐indol‐3‐yl)‐2‐((4‐nitrobenzylidene) amino)propanoic acid (INAP), was synthesized from tryptophan and nitrobenzaldehyde by the reflux method and characterized by various analytical methods. The prepared INAP acted as a chemical sensor and displayed outstanding sensitivity and choosiness characteristics for Cu2+ ions an aqueous solvent. In the presence of Cu2+, it demonstrated a fluorescence change in an aqueous medium with a “turn‐off” phenomenon via complex‐mediated energy transfer characteristics, and the method of continuous variation suggested a 1 : 2 complex formation of the metal ion with INAP. The LOD of the sensor system was calculated to be 1.3 μM for the Cu2+ ion. In addition, the INAP fluorescent probe was applied to tap water samples and found acceptable recoveries. These results suggest that the newly fabricated sensor system would be explored as a chemosensor for the recognition of Cu2+ ions in environmental samples.
Pyrolysis of Corn Husk Enabled with Tin Oxide Nano Particles: Kinetic Studies and Biochar as Electrode Material
Authors: Prabhahar R. Saravana Sathiya , Vasiraja N. , Manohara Babu I. , Sakthivel A. , Ibrahim Raja M. 
Published: July 2024

AbstractHandling of agricultural residues is a major concern today, since they pose a serious threat to the environment. Pyrolysis is one among the different techniques explored across the globe towards the effective conversion of these crop residues into various useful products. In this work, the degradation behaviour of corn husk loaded with tin oxide nanoparticles and raw corn husk are characterized separately by employing thermogravimetric analyzer (TGA). From the thermograms obtained, the energy required for facilitating the degradation process with the aid of the catalyst is found to be 98.48 kJ/mol. Further, the corn husk loaded with prepared tin oxide nanoparticles (0.1 g& 0.2 g) is subjected to pyrolytic degradation at different temperature ranges from 400 °C to 550 °C and compared with thermal pyrolysis. The biochar retained from the pyrolysis process is investigated for its efficacy as an energy storage material after coating them over graphite sheet. Electrochemical analysis reveals the fabricated SnO2/biochar nanocomposite have excellent energy storage characteristics (205 F/g at a scan rate of 10 mV/s) which was attributed to the presence of facile architecture with porous surface area. The outcomes of the present study open fresh gateways for the innovative electrodes in energy domain.
One‐Step Hydrothermal Deposition of AgSbS2‐xSex Thin Films for Solar Cell Applications
Authors: Peng Xiaoqi , Sheng Shuwei , Gao Huihui , Huang Lei , Zhao Qi , Wang Haolin , Zhu Changfei , Tang Rongfeng , Chen Tao 
Published: July 2024

AbstractAgSbS2‐xSex is a promising light‐harvesting material for thin film solar cells, characterized by nontoxicity, high chemical stability, and excellent optoelectronic properties. However, the complex chemical composition of AgSbS2‐xSex poses significant challenges to thin film preparation, giving rise to an intensive dependence on multi‐step preparation methods. Herein, a hydrothermal method is developed for depositing AgSbS2‐xSex films and achieves one‐step preparation of this kind of thin film materials for the first time. This method can provide sufficient energy for atomic nucleation and adsorption on the substrate surface to promote nuclei aggregation and grow into films. Meanwhile, it achieves control of the chemical kinetics of the deposition solution by introducing EDTA‐2Na as an additive and suppressing the enrichment of Ag2Se impurities at the substrate interface. As a result, a high‐purity AgSbS2‐xSex film with compact and flat morphology is prepared and assembled into solar cells. The device delivers a power conversion efficiency of 3.04% under standard illumination, which is currently the highest efficiency for AgSbS2‐xSex solar cells fabricated by the one‐step method. This study provides a facile and promising method for the controllable preparation of high‐quality AgSbS2‐xSex thin films and promoting their application in solar cells.
Biomimetic Porous MXene Antibacterial Adsorbents with Enhanced Toxins Trapping Ability for Hemoperfusion
Authors: Wang Zhihua , Cao Yuanhang , Gu Tingxiang , Wang Luping , Chen Qiang , Wang Jiemin , Zhao Changsheng 
Published: July 2024

Abstract2D transition metal carbides and nitrides, i.e., MXene, are recently attracting wide attentions and presenting competitive performances as adsorbents used in hemoperfusion. Nonetheless, the nonporous texture and easily restacking feature limit the efficient adsorption of toxin molecules inside MXene and between layers. To circumvent this concern, here a plerogyra sinuosa biomimetic porous titanium carbide MXene (P‐Ti3C2) is reported. The hollow and hierarchically porous structure with large surface area benefits the maximum access of toxins as well as trapping them inside the spherical cavity. The cambered surface of P‐Ti3C2 prevents layers restacking, thus affording better interlaminar adsorption. In addition to enhanced toxin removal ability, the P‐Ti3C2 is found to selectively adsorb more middle and large toxin molecules than small toxin molecules. It possibly originates from the rich Ti‐deficient vacancies in the P‐MXene lattice that increases the affinity with middle/large toxin molecules. Also, the vacancies as active sites facilitate the production of reactive oxygen under NIR irradiation to promote the photodynamic antibacterial performance. Then, the versatility of P‐MXene is validated by extension to niobium carbide (P‐Nb2C). And the simulated hemoperfusion proves the practicability of the P‐MXene as polymeric adhesives‐free adsorbents to eliminate the broad‐spectrum toxins.
Realizing Direct Uranium Extraction from Seawater Using a Carboxyl‐g‐C3N4/CdS Hydrogel
Authors: Li Ping , He Teng , Wang Jingjing , Ou Niya , Liang Jianjun , Wang Gen , Fan Qiaohui 
Published: July 2024

AbstractThe photocatalytic U(VI) reduction is regarded as an effective strategy for recovering uranium. However, its application in seawater uranium extraction poses challenges due to limited reactivity in the presence of carbonate and under atmospheric conditions. In the present study, a photoactive hydrogel made of carboxyl‐functionalized g‐C3N4/CdS (CCN/CdS) is designed for extracting uranium. The carboxyl groups on g‐C3N4 enhance the affinity toward uranyl ions while CdS facilitates the activation of dissolved oxygen. Under atmospheric conditions, the prepared hydrogel catalyst achieves over 80% reduction rate of 0.1 mM U(VI) within 150 min in the presence of carbonate, without the assistance of any electron donors. During the photocatalytic process, U(VI) is reduced to form UO2+x. The hydrogel catalyst exhibits a high uranium extraction capacity of >434.5 mg g⁻1 and the products can be effectively eluted using a 0.1 M NaCO3 solution. Furthermore, this hydrogel catalyst offers excellent stability, good recyclability, outstanding antifouling activity, and ease of separation, all of which are desirable for seawater uranium extraction. Finally, the test in real seawater demonstrates the successful extraction of uranium from seawater using the prepared hydrogel catalyst.
Hyaluronic Acid Receptor‐Mediated Nanomedicines and Targeted Therapy
Authors: Ouyang Qiuhong , Zhao Ying , Xu Kunyao , He Yuechen , Qin Meng 
Published: July 2024

AbstractHyaluronic acid (HA) is a naturally occurring polysaccharide found in the extracellular matrix with broad applications in disease treatment. HA possesses good biocompatibility, biodegradability, and the ability to interact with various cell surface receptors. Its wide range of molecular weights and modifiable chemical groups make it an effective drug carrier for drug delivery. Additionally, the overexpression of specific receptors for HA on cell surfaces in many disease states enhances the accumulation of drugs at pathological sites through receptor binding. In this review, the modification of HA with drugs, major receptor proteins, and the latest advances in receptor‐targeted nano drug delivery systems (DDS) for the treatment of tumors and inflammatory diseases are summarized. Furthermore, the functions of HA with varying molecular weights of HA in vivo and the selection of drug delivery methods for different diseases are discussed.
Advancing Energy Sustainability Through Solar‐to‐Fuel Technologies: From Materials to Devices and Systems
Authors: Li Xintong , Yu Zexin , Zhang Chunlei , Li Bo , Wu Xin , Liu Yizhe , Zhu Zonglong 
Published: July 2024

AbstractTo achieve carbon neutrality and sustainable development, innovative solar‐to‐fuel systems have been designed through the integration of solar energy harvesting and electrochemical devices. Over the last decade, there have been notable advancements in enhancing the efficiency and durability of these solar‐to‐fuel systems. Despite the advancements, there remains significant potential for further improvements in the performance of systems. Enhancements can be achieved by optimizing electrochemical catalysts, advancing the manufacturing technologies of photovoltaics and electrochemical cells, and refining the overall design of these systems. In the realm of catalyst optimization, the effectiveness of materials can be significantly improved through active site engineering and strategic use of functional groups. Similarly, the performance of electrochemical devices can be enhanced by incorporating specific additives into electrolytes and optimizing gas diffusion electrodes. Improvements in solar harvesting devices are achievable through efficient passivant and self‐assembled monolayers, which enhance the overall quality and efficiency of these systems. Additionally, optimizing the energy conversion efficiency involves the strategic use of DC converters, photoelectrodes, and redox media. This review aims to provide a comprehensive overview of the advancements in solar‐powered electrochemical energy conversion systems, laying a solid foundation for future research and development in the field of energy sustainability.
The rise and fall of the Iberian cobras (Elapidae, Naja) in the context of their European and global fossil record
Authors: Villa Andrea , Quadros Ana B. , Delfino Massimo , Luján Àngel H. , Bolet Arnau , Casanovas‐Vilar Isaac , Robles Josep M. , Alba David M. 
Published: July 2024

AbstractVery few remains of elapid snakes are known from the Iberian Peninsula, but these include a probable endemic extinct species of cobra, Naja iberica from the Late Miocene. We here describe isolated cobra vertebrae from several Middle–Late Miocene localities in the Vallès‐Penedès Basin (Catalonia, Spain). All of these fossils are herein referred to an indeterminate species of the genus Naja. These remains are the first conclusive evidence that cobras were present in Iberia before the Messinian Salinity Crisis, and that they persisted there throughout the Miocene (and ultimately until the Pliocene). Recently, a phylogeny of extinct Naja based on cranial and vertebral morphology recognized N. iberica as a distinct lineage separate from the Central European one, represented mainly by Naja romani. However, due to taxonomic uncertainties, it is still unclear whether Iberian cobras were all part of a single lineage or whether several Naja lineages inhabited the Iberian Peninsula. They went extinct in Iberia before the end of the Pliocene. In the Vallès‐Penedès Basin, cobras were living in a mosaic environment, surviving through different phases characterized by different environmental features.
Two‐Dimensional MXene‐Based Electrocatalysts: Challenges and Opportunities
Authors: Kaleem Shabbir Muhammad , Arif Fozia , Asghar Haleema , Irum Memon Sanam , Khanum Urooj , Akhtar Javeed , Ali Akbar , Ramzan Zeeshan , Aziz Aliya , Memon Ayaz Ali , Hussain Thebo Khalid 
Published: July 2024

AbstractMXene, regarded as cutting‐edge two‐dimensional (2D) materials, have been widely explored in various applications due to their remarkable flexibility, high specific surface area, good mechanical strength, and interesting electrical conductivity. Recently, 2D MXene has served as a ideal platform for the design and development of electrocatalysts with high activity, selectivity, and stability. This review article provides a detailed description of the structural engineering of MXene‐based electrocatalysts and summarizes the uses of 2D MXene in hydrogen evolution reactions, nitrogen reduction reactions, oxygen evolution reactions, oxygen reduction reactions, and methanol/ethanol oxidation. Then, key issues and prospects for 2D MXene as a next‐generation platform in fundamental research and real‐world electrocatalysis applications are discussed. Emphasis will be given to material design and enhancement techniques. Finally, future research directions are suggested to improve the efficiency of MXene‐based electrocatalysts.
Polystyrene Microplastics Degradation by Microbial Consortium From Jakarta Bay
Authors: Yolanda Della Mariam , Anggiani Milani , Agung Mochamad Untung Kurnia , Anggraeni Santi Rukminita , Afianti Nur Fitriah 
Published: July 2024

ABSTRACTThe continuously increasing accumulation of microplastics in the environment, such as polystyrene (PS), has posed an ecological and health threat. However, the information and biodegradation capability of plastics, including polystyrene, was still in the infancy stage in Indonesia. This study explored the potential of microbial consortia from Jakarta Bay to degrade polystyrene microplastics. The consortia were obtained from plastic waste with biofilms on their surfaces, collected from three stations in Jakarta Bay. The research enriched the biofilm's consortia using 1/10 Zobell marine broth media supplemented with 0.1% PS microplastics. Using enriched cultures, biodegradation tests were performed in a mineral salt medium with 0.2% PS microplastics as a sole carbon source for 60 days at 27°C, 120 rpm. Microbial consortia from Jakarta Bay showed an ability to perform polystyrene biodegradation. The calculated weight loss of the microplastics after 60 days of incubation was between 4% and 6.4%. The biodegradation of PS microplastics by the microbial consortium was also indicated by FTIR spectra, which showed changes in functional group transmittances and were confirmed by SEM data showing holes formation on PS surfaces. The results provide a baseline study for further research development in Indonesia's polystyrene biodegradation technology and management.
Oesophageal adenocarcinoma presenting as a foreign body induced intrathoracic abscess in a dog
Authors: Brady Emily Charlotte , Owen Laura , Wong Hannah , Kortum Andre , Herrtage Michael Edward 
Published: July 2024

AbstractA 9‐year‐old, male, entire Irish setter was referred for further investigation of a chronic cough, anorexia, weight loss and lethargy. Computed tomography revealed a large ovoid encapsulated lesion, with a gas and fluid attenuating centre, and an intralesional mineral opacity. The lesion ran close to the caudal oesophagus, and extended cranially within the pulmonary parenchyma. Endoscopy revealed a communication between the lumen of the distal oesophagus and the lesion, which contained a purulent discharge and plant material. Based on the computed tomography and endoscopic findings, the diagnosis was expected to be a thoracic abscess, secondary to foreign body migration or penetration; however, surgical resection and histopathological analysis of the lesion revealed an oesophageal adenocarcinoma. This case details the unusual presentation of an oesophageal adenocarcinoma, with endoscopic and computed tomography findings that mimicked a thoracic abscess with an intralesional foreign body.