bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of the COVID-19 pandemic on health-related quality of life of cancer patients in British Columbia
Authors: Izadi-Najafabadi Sara , McTaggart-Cowan Helen , Halperin Ross , Lambert Leah , Mitton Craig , Peacock Stuart 
Published: August 2024

Abstract
Background
The COVID-19 pandemic resulted in unprecedented changes to cancer care in many countries, impacting cancer patients’ lives in numerous ways. This study examines the impact of changes in cancer care on patient’s health-related quality of life (HRQL), which is a key outcome in cancer care. The study aims to estimate patients’ self-reported HRQL before and during the pandemic and identify predictive factors for their physical and mental wellbeing.

Method
The study employed the large-scale Outpatient Cancer Care (OCC) Patient Experience Survey, including the Veterans RAND 12-Item Health Survey, to evaluate cancer patients’ experiences and HRQL before (January to May 2020) and during the COVID-19 pandemic (May to July 2021). Paired t-tests were conducted to compare differences in Physical Component Scores (PCS) and Mental Component Scores (MCS) before and during the pandemic. Multivariable linear regressions were employed to investigate the factors (sociodemographic, clinical, and patient-reported experience) influencing PCS and MCS during the pandemic.

Results
PCS decreased significantly during the pandemic, while MCS remained stable. Lower PCS contributors included older age, more telehealth visits, self-reported hospitalization, and a longer time since the last cancer diagnosis. Higher PCS was associated with urban residence, higher MCS during the pandemic, and perceived active Healthcare Provider (HCP) involvement. For MCS, lower scores related to female gender and more telehealth visits, while higher scores were associated with being white, higher education, high MCS before the pandemic, and perceived active HCP involvement.

Conclusion
The OCC Patient Experience Survey provides a unique patient level data set measuring HRQL pre- and post- the onset of the COVID-19 pandemic. The study highlights challenges faced by cancer patients during the pandemic, with a significant reduction in PCS. However, the stability in MCS suggests effective coping mechanisms. Sociodemographic, clinical, and telehealth-related variables play a complex role in shaping both PCS and MCS. Perceived HCP involvement emerges as a crucial factor correlating with higher PCS and MCS. Navigating the post-pandemic era necessitates interventions fortifying patient-provider relationships, optimizing healthcare support systems, such as telehealth services, and prioritizing mental-well-being given its impact on both PCS and MCS.
Cystic endometrial stromal sarcoma mimicking a cystic ovarian tumor : an unusual presentation
Authors: Singh Divya , Khan Shazia , Varma Kachnar , Singh Anshul , Misra Vatsala 
Published: August 2024

AbstractLow grade endometrial stromal sarcoma (LGESS) typically presents as a solid intracavitary or intramural uterine mass. On imaging, LGESS is usually seen as an endometrial or myometrial solid mass. Cystic change is unusal and may lead to a differential diagnosis of an ovarian mass as was seen in the present case. Here we present a case of a 38 year old woman who presented with a cystic ovarian mass clinically and radiologically. Per-operatively, it was found to be a multiloculated cystic mass, filled with serosanguinous fluid, in the uterine fundus. Histopathological examination showed a tumor mass composed of mainly spindle cells arranged in fascicular pattern showing marked myxoid degeneration and cystic areas. On immunohistochemistry(IHC), tumor cells showed positivity for CD 10, ER, PR, SMA and desmin while HMB45 was negative. Based on histopathological and IHC, a diagnosis of LGESS was made. Most cases of cystic uterine masses have a benign course but, LGESS exhibits a relatively poorer outcome and a risk of metastasis. Hence, we present this case for its unusual presentation which mimics an ovarian mass but has worse prognosis.
The effects of intraoperative use of blue dyes in pediatric pilonidal sinus disease—a retrospective exploratory cohort study
Authors: Engels Marie N. , Lüken-Darius Britta , Oetzmann von Sochaczewski Christina , Heydweiller Andreas C. 
Published: August 2024

Abstract
Background
Intraoperative use of methylene blue has been shown to reduce postoperative complications and recurrence rates in adults. It has however not been assessed if these beneficial effects would also apply to pediatric pilonidal sinus disease with its high recurrence rates. We, therefore, aimed to assess its effects on complications and recurrences in our retrospective exploratory cohort study.

Methods
Of 55 consecutive children treated in our centre between January 2009 and December 2020, 48 were retrospectively included. We used logistic regression with a priori chosen predictors of intraoperative use of blue dyes, previous surgery for pilonidal sinus disease, and the presence of comorbidities on the composite outcome of complications and recurrence. Cramér’s V was used to explore associations between the use of blue dyes and the extent of resection.

Results
The median age in our cohort was 15.3 years. Five patients were below 2 years of age, and 24 (50%) of them were males. Chronic diseases were present in 13 (27%) patients, eight had previously been operated on for pilonidal sinus disease, and blue dyes were used in 34 patients (71%). Their intraoperative use was linked to the composite outcome with an odds ratio of 5.41 (95% confidence interval (CI) 1.52–25.34, P = 0.017) as were comorbidities with an odds ratio of 1.86 (95% CI 1.18–3.25, P = 0.014), but not re-do surgery (odds ratio 2.94 (95% CI 0.37 23.42, P = 0.3)). The use of blue dyes was associated with larger resections (Cramér’s V 0.556 (95% CI 0.329–0.74)).

Conclusion
The intraoperative use of blue dyes was negatively associated with complications and recurrences in pediatric pilonidal sinus disease. However, if blue dyes were used, the extent of resection was also larger. Larger resections had been shown before to be associated with complications and recurrences, too. This potential interaction requires further elucidation in future studies.
Making history, making place—contextualising the built heritage of world expos 2010 and 2015
Authors: Honisch Pascal 
Published: August 2024

AbstractBe it the 1873 World’s Fair in Vienna, which established the city's status as a link between the Occident and Orient, or the very first Great Exhibition in 1851 in London, which showcased the then British empire to a global public and the world to its domestic visitors. World’s fairs have been and are still an indispensable part of a shared human history as well as an indicator of a country's economic and cultural relevance on a global scale. They are undoubtedly politically motivated drivers of collective memories and, in turn, nation-building processes. This is why they are not only publicly discussed and thoroughly documented in archives but also often manifested in buildings that long outlast these events and themes but continue to tell their tales. This article elaborates on the ways in which world’s fairs (or expos) have been used as catalysts to develop cities and how they themselves – though ephemeral phenomena – ultimately found their way into urban landscapes and historiography. Moreover, based on his own empirical studies on the last two expos of Shanghai (2010) and Milan (2015), the author elaborates on the placemaking procedures that precede and follow these mega-events, reflecting on the ensuing public discourse to (de)legitimate them, its limitations, and effects on the urban legacy of the aforementioned expos. He then presents an overarching discussion on their built heritage.
Non-magnetic layers with a single symmetry-protected Dirac cone: Which additional dispersions must appear?
Authors: Damljanović V. 
Published: August 2024

Abstract
In two-dimensional (2D), non-magnetic materials, a single Dirac cone at high-symmetry point (HSP) of the Brillouin zone (BZ), akin to the one in graphenes’ band structure, cannot appear as the only quasiparticle at the Fermi level. Here we found two layer groups with time-reversal symmetry, among all possible both without and with spin-orbit coupling, that host one Dirac cone at HSP and we show which additional dispersions appear: a pair of Dirac lines on opposite BZ edges and a pair of Dirac cones that can be moved but not removed by symmetry preserving perturbations, on the other two BZ edges. We illustrate our theory by a tight-binding band structure and discuss real 2D materials that belong to one of the two symmetry groups. Finally, we single out smaller or bigger discrepancies among the published papers on the same or related topic.
The Cortisol Awakening Response: Regulation and Functional Significance
Authors: Stalder Tobias , Oster Henrik , Abelson James L , Huthsteiner Katharina , Klucken Tim , Clow Angela 
Published: August 2024

Abstract
In healthy individuals, the majority of cortisol secretion occurs within several hours surrounding morning awakening. A highly studied component of this secretory period is the cortisol awakening response (CAR), the rapid increase in cortisol levels across the first 30 to 45 minutes after morning awakening. This strong cortisol burst at the start of the active phase has been proposed to be functional in preparing the organism for the challenges of the upcoming day. Here, we review evidence on key regulatory and functional processes of the CAR and develop an integrative model of its functional role. Specifically, we propose that, in healthy individuals, the CAR is closely regulated by an intricate dual-control system, which draws upon key circadian, environmental, and neurocognitive processes to best predict the daily need for cortisol-related action. Fine-tuned CAR expression, in turn, is then assumed to induce potent glucocorticoid action via rapid nongenomic and slower genomic pathways (eg, affecting circadian clock gene expression) to support and modulate daily activity through relevant metabolic, immunological, and neurocognitive systems. We propose that this concerted action is adaptive in mediating two main functions: a primary process to mobilize resources to meet activity-related demands and a secondary process to help the organism counterregulate adverse prior-day emotional experiences.
Clinical Characteristics and Outcomes of Patients with Well-Differentiated Papillary Peritoneal Mesothelial Tumors
Authors: Offin Michael , Aguirre Nicole , Yang Soo Ryum , Sauter Jennifer L. , Karagkounis Georgios , Mohamed Mostafa , Cercek Andrea , Kundra Ritika , Zhang Yanming , Wang Hui Mei , Morris Marty P. , Ladanyi Marc , Nash Garrett M. , Zauderer Marjorie G. 
Published: August 2024

Abstract
Purpose
Well-differentiated papillary peritoneal mesothelial tumors (WDPMTs) are understudied and discrete from peritoneal mesotheliomas (PMs). We report clinicopathologic characteristics and outcomes of a large prospective WDPMT cohort.

Methods
Patients with WDPMT identified between August 2007 and December 2020 were followed through January 2023. Clinical characteristics and outcomes were annotated. Overall survival (OS) was assessed from pathologic diagnosis. Germline variants were analyzed, and targeted next-generation sequencing (NGS; MSK-IMPACT) data were compared to PMs and diffuse pleural mesotheliomas (DPMs).

Results
Among 54 patients, median age at diagnosis was 55 (range 20–76), 50% were female (n = 27), and 46% were smokers (n = 25; median 8 pack/years). Most (94%, n = 51) WDPMTs were found during surgical explorations for other indications, primarily other malignancies. Two patients underwent surgical resection for WDPMT; none received systemic therapy for WDPMT. Median OS was not reached (19/54; median follow up 4.5 years). Somatic NGS was available for 35% (19/54) of patients. TRAF7 alterations were enriched in WDPMT (89%; 17/19) compared with PM (0%; 0/50; p < 0.0001) and DPM (0%; 0/74; p < 0.0001). In WDPMT compared with PM and DPM, there were less BAP1 (0% [0/0] vs. 4% [8/50] vs. 46% [34/74]; p = 0.001 and p < 0.0001, respectively) and NF2 (0% [0/0] vs. 24% [12/50] vs. 31% [23/74]; p = 0.03 and p = 0.001 respectively) alterations. Pathogenic germline variants were present in 23% (4/17) of WDPMTs.

Conclusions
Well-differentiated papillary peritoneal mesothelial tumors were primarily incidental findings. There was no WDPMT-related mortality, so there was no distinct role for routine cytoreductive surgery or systemic therapy. Genomic profiles can help to differentiate WDPMT from DPM and PM.
Site Reassignment for Mobile Outreach Teams: Investigating the Effectiveness of Decentralized Decision Making
Authors: van Rijn Lisanne , de Vries Harwin , Van Wassenhove Luk N. 
Published: August 2024

Problem definition: United Nations Sustainable Development Goal (SDG) 3.8 states that health coverage should be universal by 2030. This is challenging in rural and poor areas. To address this challenge, mobile outreach teams of healthcare workers visit a fixed set of remote sites to provide healthcare services. Because of dynamics in demand and supply, once-rational site-to-team assignment decisions can become far from optimal over time. This paper considers the problem of reassigning sites to teams to maximize effectiveness. Solving this problem through a central planner does not fit the context: outreach teams commonly have a high degree of decision-making autonomy. We study a decentralized approach where subsets of teams collaborate in a series of team meetings to reassign sites. The key question for decision makers is whether and when such an approach is effective. Methodology/results: We propose a mixed-integer programming model for centralized site reassignment. We extend this model to represent the decentralized approach and develop a set of simple decision rules for this approach. We use empirical data from six country outreach programs of the nongovernmental organization MSI Reproductive Choices. Our results suggest that, when properly designed, decentralized decision making performs close to centralized decision making, and even outperforms it in the case of inaccurate information at the central level. The finding remains valid when demand and supply fluctuate, and is insensitive to the chosen objective. Managerial implications: Humanitarian organizations currently deploy mobile outreach teams to provide a wide variety of health services. We present several useful insights for decision makers in humanitarian organizations when making design choices, taking account of context. In particular, we show that decentralized site reassignment provides a feasible and effective alternative to centralized approaches in many contexts. Supplemental Material: The online supplement is available at https://doi.org/10.1287/msom.2021.0437 .
Reduction in rate of implant waste associated with robotic-assisted total hip arthroplasty
Authors: Shen Tony S. , Cheng Ryan , Chiu Yu-Fen , McLawhorn Alexander S. , Figgie Mark P. , Westrich Geoffrey H. 
Published: August 2024

AimsImplant waste during total hip arthroplasty (THA) represents a significant cost to the USA healthcare system. While studies have explored methods to improve THA cost-effectiveness, the literature comparing the proportions of implant waste by intraoperative technology used during THA is limited. The aims of this study were to: 1) examine whether the use of enabling technologies during THA results in a smaller proportion of wasted implants compared to navigation-guided and conventional manual THA; 2) determine the proportion of wasted implants by implant type; and 3) examine the effects of surgeon experience on rates of implant waste by technology used.MethodsWe identified 104,420 implants either implanted or wasted during 18,329 primary THAs performed on 16,724 patients between January 2018 and June 2022 at our institution. THAs were separated by technology used: robotic-assisted (n = 4,171), imageless navigation (n = 6,887), and manual (n = 7,721). The primary outcome of interest was the rate of implant waste during primary THA.ResultsRobotic-assisted THA resulted in a lower proportion (1.5%) of implant waste compared to navigation-guided THA (2.0%) and manual THA (1.9%) (all p < 0.001). Both navigated and manual THA were more likely to waste acetabular shells (odds ratio (OR) 4.5 vs 3.1) and polyethylene liners (OR 2.2 vs 2.0) compared to robotic-assisted THA after adjusting for demographic and perioperative factors, such as surgeon experience (p < 0.001). While implant waste decreased with increasing experience for procedures performed manually (p < 0.001) or with navigation (p < 0.001), waste rates for robotic-assisted THA did not differ based on surgical experience.ConclusionRobotic-assisted THAs wasted a smaller proportion of acetabular shells and polyethylene liners than navigation-guided and manual THAs. Individual implant waste rates vary depending on the type of technology used intraoperatively. Future studies on implant waste during THA should examine reasons for non-implantation in order to better understand and develop methods for cost-saving.Cite this article: Bone Jt Open 2024;5(8):715–720.
Polarization non-reciprocity error suppression in dual-polarization fiber optic gyroscopes
Authors: Liu Yakang , Liu Yishi , Jin Jichao , Chen Xingfan 
Published: August 2024

The dual-polarization interferometric fiber optic gyroscope is distinguished by the
fact that both orthogonal polarized light beams in the fiber coil are
simultaneously sensitive to the rotation rate. The relative intensity
noise can be effectively suppressed due to the strong correlation
between the two polarized light beams. However, the system exhibits
significant polarization non-reciprocity errors, which worsen the bias
instability. In this paper, we demonstrate how modulation depth
affects the angular random walk and the bias instability. Polarization
non-reciprocity errors can be efficiently mitigated while the angular
random walk approaches optimal value by adjusting the modulation depth
to π/2rad rather than 2.7 rad. It is
confirmed that the bias instability and angular random walk can be
simultaneously improved by optimizing the modulation depth without
increasing the complexity of the optical path. Experimental results
indicate that for a 500-m-long fiber coil, the bias instability is
improved from 0.025∘/h (2.7 rad) to 0.010∘/h (π/2rad) while the angular random walk
remains at 0.001∘/h through modulation depth
optimization, which advances its application in navigation.
Study of the population genetic structure of Opisthorchis-like eggs in northern Thailand using mitochondrial genes
Authors: Suwannahitatorn Picha , Mungthin Mathirut , Subrungruang Ittisak , Charoensuk Lakhanawan , Aksorn Nithikoon , Buathong Saiwasan 
Published: August 2024

Background
Opisthorchis-like eggs are a public health problem in northern and northeastern Thailand. However, the genetic epidemiology and structure of these parasites in northern Thailand are unknown. Thus, this study investigated their population genetic structure using cytochrome c oxidase subunit 1 (cox1) and NADH dehydrogenase subunit 1 (nad1) nucleotide sequences.

Methodology/Principal findings
A study was conducted in the hill tribe regions of Chiang Mai Province, northern Thailand. Internal transcribed spacer 2 polymerase chain reaction and restriction fragment length polymorphism were used to distinguish 205 positive feces samples for Opisthorchis-like eggs. The results showed that the prevalence of O. viverrini and Haplorchis taichui was 10.5% and 38.2%, respectively, and the co-infection rate was 37.2%. To determine the genetic structure of O. viverrini and H. taichui using cox1 and nad1 genes, genetic analysis was performed using 30 randomly chosen fecal samples for Opisthorchis-like eggs. Pairwise FST analysis indicated that O. viverrini and H. taichui displayed nonsignificant genetic differentiation within Chiang Mai Province and between interpopulations from different geographic areas. Moreover, within the intrapopulation in Chiang Mai Province, cox1 presented higher gene flow than nad1 in O. viverrini, while nad1 demonstrated higher gene flow than cox1 in H. taichui. The neutrality tests based on Fu’s Fs indicated population expansion and selective sweep from bottleneck or hitchhiking in O. viverrini and H. taichui populations, supported by haplotype network patterns. Phylogenetic tree analysis based on cox1 and nad1 revealed the monophyly of O. viverrini and H. taichui and genetic relationships with other isolates collected from Thailand, Lao People’s Democratic Republic (PDR), and Vietnam.

Conclusions/Significance
This study investigated the molecular discrimination and genetic structure of Opisthorchis-like eggs in northern Thailand. The genetic information derived from this study could be associated with the background, molecular epidemiology, and disease severity of these parasites.
The validity and safety of multispectral light emitting diode (LED) treatment on grade 2 pressure ulcer: Double-blinded, randomized controlled clinical trial
Authors: Lim Nam Kyu , Goo Hyeyoon , Yoon Sung-Ryeong , Ahn Jin Chul , Hong Namgue , Choi Young Hoon , Bang Hyung Bin , Kim Sungyeon , Choi Yong Won , Chung Phil-Sang 
Published: August 2024

Purpose
The management of pressure ulcers (PUs) poses challenges due to their chronic nature and the lack of established conservative treatment methods. In this clinical trial, our objective was to examine the validity and safety of using a light-emitting diode device contained four wavelengths in the treatment of grade 2 sacral PUs.

Method
A total of 38 patients were randomly assigned to two groups: sham device (Sham) and experimental device (LED) group. The treatment sessions were conducted over a period of four weeks, with a frequency of three times per week. The study was conducted in a double-blinded manner. The study assessed the primary validity by measuring wound size and re-epithelialization after 0 and 4 weeks. Secondary evaluations included epidermal regeneration, collagen density, and immunological markers. Safety was evaluated by monitoring adverse reactions throughout the trial.

Result
The presence of eschar was found to have a significant impact on wound healing. Sham consisted of 15 wounds without eschar, while LED had nine. After treatment in without eschar situation, the post-treatment size of wounds in Sham was 13.80 ± 20.29%, while it was 3.52 ± 6.68% in LED. However, there was no significant difference (p = 0.070). And analysis of epidermal thickness showed a significant increase in LED (495.62 ± 327.09 μm) compared to Sham (195.36 ± 263.04 μm) (p < 0.0001).

Conclusion
While LED treatment had a potential for wound reduction in PUs without eschar, we could not uncover evidence to support the efficacy of LED treatment in grade 2 PUs.