bluuebunny/crossref_metadata_2025_split huggingface dataset:
A review on regulatory affairs and regulatory requirements for new drug approval
Authors: Sireesha Badri , S Haritha , S Lakshmi Thriveni , P Nikitha , U V. S. Vijaya Lakshmi 
Published: February 2025

Regulatory affairs in the pharmaceutical industry are essential as the sector grows rapidly; the demand for regulatory affairs experts is increasing. Regulatory affairs professionals to meet the industry's evolving needs in the face of global competition. Regulatory affairs are a profession that serves as the interface between pharmaceutical industries and government authorities worldwide. Developing a new drug is a lengthy process, spanning several years and encompassing discovery, toxicology studies, and clinical trials.Pharmaceutical drug regulatory affairs address the various registration criteria for pharmaceutical products.Due to the desire of Protecting public health worldwide is a top priority. A new profession called pharmacy was created. Developing a new drug is a complex and lengthy process that requires extensive research and development across multiple disciplines, including chemistry, manufacturing, controls, preclinical science, and clinical trials. This article will focus on the drug approval process in three major regions: the United States, Europe, and India.
A review of pharmacognostic and pharmacological study on vaccinium cyanococcus
Authors: S Madhu Sudhan , S Asma Parveen , Y Prapurna Chandra 
Published: February 2025

The Vaccinium L. (Ericaceae) genus consists of a globally widespread and diverse genus of around 4250 species, of which the most valuable is the Vaccinioidae Sub-family. (1) The current review focuses on the distribution, history, bioactive compounds, and health-related effects of three species: cranberry, blueberry, and huckleberry. Several studies highlight that the consumption of Vaccinium spp. presents numerous beneficial health-related outcomes, including antioxidant, antimicrobial, anti-inflammatory, and protective effects against diabetes, obesity, cancer, neurodegenerative diseases and cardiovascular disorders. These plants’ prevalence and commercial value have enhanced in the past several years; thus, the generated by-products have also increased. Consequently, the identified phenolic compounds found in the main bioactive compounds identified in this genus belong to anthocyanins (cyanidin, malvidin, and delphinidin), flavonoids (quercetin, isoquercetin, and astragalin), phenolic acids (gallic, p-Coumaric, cinnamic, syringic, ferulic, and caffeic acids), and iridoids.their beneficial effects on vascular and glucoregulatory function. Blueberry phytochemicals may affect gastrointestinal microflora and contribute to host health. These aspects have implications in degenerative diseases and conditions as well as the aging process. to better understand the potential for anthocyanin-rich blueberries to benefit public health.
Educación Estadística en la Sociedad. Una experiencia de Servicio Social. Panamá, 2024
Authors: Ramírez Anabel , Cruz Clara Elena , Sánchez Daniel , Douglas Ricardo 
Published: February 2025

El proyecto denominado como: “Alfabetización Estadística (E-Alfa)” es una actividad de extensión realizada en el marco del Servicio Social de la Escuela de Estadística, el cual busca dar a conocer a la población sobre la importancia y la utilidad de esta ciencia como una herramienta para la recolección, procesamiento y análisis de datos para la toma de decisiones en determinados contextos, por lo general en el campo de la salud, en lo cotidiano considerando la diversidad del enfoque profesional que se quiere aplicar (Nowacki, et al., 2024). Este enfoque permite vincular el aprendizaje estadístico con problemas reales, siguiendo un ciclo completo de investigación que incluye la recolección, organización, análisis y comunicación de datos (Alsina et al., 2023; Wild & Pfannkuch, 1999).
El objetivo de esta actividad se centra en desarrollar una técnica estadística desde la recolección de los datos hasta su publicación. Se emplea una metodología activa, en el cual tanto los estudiantes participantes como la población intervenida logran ampliar sus conocimientos sobre la Estadística desde el enfoque de un caso práctico. A través de metodologías activas, los estudiantes trabajan en equipo para implementar técnicas estadísticas, aplicadas a las diversas regiones de salud, lo que no solo fortalece sus competencias estadísticas, sino también habilidades interpersonales y sociales (Rodríguez-Muñiz et al., 2020).
La población referida para el desarrollo del Servicio Social consta de pacientes y personal de salud que se encontraban en las instalaciones de salud de las regiones de Panamá Centro y Panamá Oeste. Se destaca que este tipo de experiencias promueven un aprendizaje significativo tanto para los estudiantes como para los beneficiarios, mejorando la percepción sobre la utilidad de la estadística en la vida diaria (Franklin et al., 2020).
EVOLUTION OF THE IDEA OF HYBRID WAR AND THE TERM IN WESTERN POLITICAL AND MILITARY THOUGHT
Authors: Yavor Raychev 
Published: February 2025

The article describe main characteristics of hybrid societies and war is accepted as normal in most hybrid societies, unlike in the West. The author give his own view to the practice forms of pre-state warfare which recognizes few of the modern limitations of war there is often no distinction between combatants and non-combatants, kidnapping takes place, massacres occur.
The article describes various definitions of the problems of a hybrid society and how they resort to international laws of war, completely rejecting them either to justify their actions or because they do not apply to them because they are Christian or Western. Examples are also given of how these societies decide the connections necessary to communicate with other modern states. It also talks about decentralized and clan hybrid societies, the hybrid power generated by hybrid societies. The article describes how a hybrid war arises, guerrilla actions, tools of psychological influence on the mood of people and decision makers and their goals that change public attitudes, causing distrust in their own government, and so on.
Examples are also given of how the "hybrid war" is aimed not only at replacing the "chips of the Bulgarians", but also at creating a new political discourse.
ЭТНОСАРАЛЫҚ ҚАТЫНАСТАРҒА БАҚ-ТЫҢ ӘСЕР ЕТУІНІҢ КЕЙБІР АСТАРЛАРЫ
Authors: Бюжеева Б.З. , Әліпбаев А.Р. , Әбдінағи Ж.С. 
Published: February 2025

Мақала бұқаралық ақпарат құралдарының қоғамдағы этносаралық қатынастарға әсер ету мәселелерін қарастыруға арналған. Ақпараттық кеңістіктің кеңеюі және ақпараттық қоғамды қалыптастыру шеңберінде цифрлық және спутниктік байланыстардың дамуы, интернет пен компьютерлік технологиялардың енгізілуі, БАҚ қызметінің трансшекаралық сипатқа ие болуына әсер етті. БАҚ әлемдік саяси өзара әрекеттесудің ерекше бір бөлігі болып табылады. Соған байланысты ол халықаралық және ұлттық деңгейлерде халықтар мен елдердің дамуына айтарлықтай әсер ететін этносаяси үрдістің жүру бағытына ықпал ете алады.
Бүгінгі таңда БАҚ этносаяси өзара әрекеттесудің ықтимал нәтижелерін айқындайтын саяси құралға айналуда. Айқындалатын нәтижелер ұлтаралық тепе-теңдікті қамтамасыз етуден, шағын этникалық қауымдастықтардың құқықтарын қолдаудан, ұлттық және жалпымемлекеттік мүдделерді үйлестіруден бастап, шовинизмді, экстремизмді, жергілікті ұлтшылдықты және этносаяси қақтығыстарды қоздыруға дейін өзгере алады.
БАҚ-тың этномәдени өзара іс-қимылдың маңызды мәселелерін жариялау кезінде әлеуметтік жауапкершілігінің болмауы қақтығыс әлеуетінің артуына және тіпті қақтығыстардың одан әрі өршуіне әкеледі. Соған байланысты қазір БАҚ әсіресе этникалық мәселелерде жоғары қақтығыстық әлеуетімен сипатталатын ерекше әлеуметтік сала ретінде танылып отыр.
Бұқаралық ақпарат құралдары этникалық топтарды қате сипаттауы арқылы, теріс «этникалық бейнелерді» құру арқылы этносаралық қарама-қайшылықты тереңдете алады. Ұлтшылдық, ксенофобия, кемсітушілік, этникалық көші-қон, этносаралық қайшылықтар, этносаралық қақтығыстар, сондай-ақ лаңкестік, діни экстремизм сияқты этносаяси қатынастардың өткір мәселелеріне БАҚ-тың реакциясы ерекше маңызға ие.
Public Health Critical Race Praxis in Maternal Health Occupational Therapy: A Framework for Race-Conscious Research and Intervention
Authors: Major Jordan C. W. , Jewell Vanessa , Bodison Stefanie C. 
Published: February 2025

This column explores the integration of the Public Health Critical Race Praxis (PHCRP) framework into maternal health occupational therapy to address racial disparities and enhance health care outcomes. The PHCRP framework provides a race-conscious methodology for examining the intersection of race, health, and systemic inequities, making its application in occupational therapy research and practice essential amid the U.S. maternal health crisis, which disproportionately affects Black birthing individuals. We highlight occupational therapy practitioners’ responsibilities, emphasizing race-conscious research, culturally informed and responsive interventions, and advocacy for equitable maternal health care policies. By leveraging the PHCRP framework, occupational therapy can take a transformative approach to address the root causes of maternal health disparities, dismantle systemic health care barriers, and improve Black maternal health outcomes. This column intentionally adopts inclusive language to recognize the diverse identities of those who give birth. We use terms such as birthing individuals and mothering to acknowledge the diverse identities, pregnancy, and childbirth experiences of all birthing individuals. Research indicates that these individuals navigate distinct experiences and may prefer gender-affirming terminology, such as transman, nonbinary, or parent, to mitigate gender dysphoria (Kukura, 2022). This inclusive approach is essential for promoting equitable, culturally affirming care because it acknowledges the additional layers of bias, discrimination, and racial inequity often experienced by non-female–identified birthing individuals. Through this lens, we aim to center diverse experiences and advocate for an occupational therapy practice that actively challenges systemic inequities and fosters equitable maternal health care.
Positionality Statement (Jordan C. W. Major): As a biracial Black–White, English-speaking, cisgender, heterosexual female with an invisible disability who was born and raised in the United States, my intersectional identity profoundly shapes my perspective, allowing me to uniquely address the nuances of racial, health, and maternal issues in health care. I am an occupational therapy practitioner currently pursuing a PhD in rehabilitation science, studying the impact of type 1 diabetes on Black maternal health. My lived experiences and academic background afford me the opportunity to center the experiences of Black mothers and birthing people through a race-conscious lens and call on my occupational therapy colleagues to do the same.
PENERAPAN MODEL PEMBELAJARAN PROBLEM BASED INSTRUCTION (PBI) UNTUK MENINGKATKAN PEMECAHAN MASALAH PADA MATA PELAJARAN IPAS TOPIK A AKU DAN KEBUTUHANKU KELAS IV SD INPRES OEBA 2 KOTA KUPANG TAHUN AJARAN 2023/2024
Authors: Moruk Yosina Aurelia , Hasyda Suryadin , Ahmad Rizqy Amelia R. 
Published: February 2025

Penelitian ini dilatarbelakangi masih rendahnya Pemecahan Masalah peserta didik kelas IV SD Inpres Oeba 2 pada mata pelajaran IPAS, dari hasil obervasi pra siklus guru sejauh ini sudah berupaya untuk menggunakan model dan strategi untuk melaksanakan capaian pembelajaran tetapi masih banyak yang belum mencapai KKM 70 dikarenakan peserta didik didalam kelas memiliki tingkat pemahaman yang bervariasi dalam memahami IPAS. Untuk mengatasi permaslahan tersebut dilakukan Penelitian Tindakan Kelas yang bertujuan untuk meningkatkan Pemecahan Masalah peserta didik pada mata pelajaran IPAS, Topik A aku dan kebutuhanku di kelas IV melalui penerapan model pembelajaran Problem Based Instruction. Dalam penelitian, peneliti menggunakan teknik pengumpulan data dan teknik analisis data menggunakan lembar observasi, postest dan angket. Hasil penelitian menunjukan bahwa pada hasil tes siklus satu rata-rata perolehan nilai peserta didik ialah 55,66%. Pada siklus dua nilai rata-rata 87,91%. Hal ini kriterianya mencapai ketuntasan yang sangat baik yang sudah mencapai indikator keberhasilan nilai rata-rata diatas KKM 70 > 85% dari jumlah 24 peserta didik. Dapat ditarik simpulan bahwa penerapan model pembelajaran Problem Based Instruction dapat meningkatkan pemecahan masalah peserta didik pada Topik A Aku dan kebutuhanku kelas IV SD Inpres Oeba 2 Tahun ajaran 2023/2024.
Monitoring and benchmarking Earth system model simulations with ESMValTool v2.12.0
Authors: Lauer Axel , Bock Lisa , Hassler Birgit , Jöckel Patrick , Ruhe Lukas , Schlund Manuel 
Published: February 2025

Abstract. Earth system models (ESMs) are important tools to improve our understanding of present-day climate and to project climate change under different plausible future scenarios. Thus, ESMs are continuously improved and extended, resulting in more complex models. Particularly during the model development phase, it is important to continuously monitor how well the historical climate is reproduced and to systematically analyze, evaluate, understand, and document possible shortcomings. Hence, putting model biases relative to observations or, for example, a well-characterized pre-industrial control run, into the context of deviations shown by other state-of-the-art models greatly helps to assess which biases need to be addressed with higher priority. Here, we introduce the new capability of the open-source community-developed Earth System Model Evaluation Tool (ESMValTool) to monitor running simulations or benchmark existing simulations with observations in the context of results from the Coupled Model Intercomparison Project (CMIP). To benchmark model output, ESMValTool calculates metrics such as the root-mean-square error, the Pearson correlation coefficient, or the earth mover's distance relative to reference datasets. This is directly compared to the same metric calculated for an ensemble of models such as the one provided by Phase 6 of the CMIP (CMIP6), which provides a statistical measure for the range of values that can be considered typical of state-of-the-art ESMs. Results are displayed in different types of plots, such as map plots or time series, with different techniques such as stippling (maps) or shading (time series) used to visualize the typical range of values for a given metric from the model ensemble used for comparison. While the examples shown here focus on atmospheric variables, the new functionality can be applied to any other ESM component such as land, ocean, sea ice, or land ice. Automatic downloading of CMIP results from the Earth System Grid Federation (ESGF) makes application of ESMValTool for benchmarking of individual model simulations, for example, in preparation of Phase 7 of the CMIP (CMIP7), easy and very user-friendly.
"Tres fantásticas semanas de provocación". Las referencias de Jrushchov a España en la asamblea de la ONU (1960)
Authors: Quintana Moraira Juan Luis 
Published: February 2025

El 20 de septiembre de 1960, Nikita Jrushchov realizó su segundo viaje a Estados Unidos encabezando la delegación de la URSS en la XV Asamblea de la ONU. Allí, revolucionó sus sesiones con una actitud beligerante,y protagonizó varios incidentes, aún recordados hoy en día. Sus críticas también alcanzaron a España. Este artículo pretende exponer convenientemente estos hechos y contextualizarlos para ayudar a entender las causas que los motivaron. Mediante el análisis de fuentes archivísticas y periodísticas de la época, se reconstruirá la cadena de acontecimientos, y se confrontarán puntos de vista. Posteriormente se procederá dar respuesta a las preguntas planteadas de inicio.
Marcin Majewski, Paweł Biedziak, Tora. Rozmowa o pierwszych pięciu księgach Biblii, Wydawnictwo Vocatio, Warszawa 2022, ss. 165.
Authors: Ćwikła Jarosław 
Published: February 2025

W 2022 r. w Warszawie nakładem Wydawnictwa Vocatio, ukazała się książka dra hab. Marcina Majewskiego oraz Pawła Biedziaka: Tora. Rozmowa o pierwszych pięciu księgach Biblii. Trzon publikacji stanowi sześć części: Wstęp do pięciu ksiąg Tory (s. 15–26), Bereszit – Księga Rodzaju (s. 27–54), Szemot – Księga Wyjścia (s. 55–78), Wajikra – Księga Kapłańska (s. 79–110), Bemindbar – Księga Liczb (s. 111–138) oraz Dewarim – Księga Powtórzonego Prawa (s. 139–165). Warto jeszcze wspomnieć, że otwiera ją Chronologia biblijna (s. 7–12), zawierająca najbardziej kluczowe daty z historii biblijnej i krótkie Wprowadzenie (s. 13–14).
Mariusz Rosik, Miejsca biblijne na każdy dzień roku. Od Edenu do Niebiańskiej Jerozolimy, Wydawnictwo Vocatio, Warszawa 2022
Authors: Ćwikła Jarosław 
Published: February 2025

W 2022 r., w Warszawie, nakładem Wydawnictwa Vocatio, ukazała się książka ks. prof. Mariusza Rosika: Miejsca biblijne na każdy dzień roku. Od Edenu do Niebiańskiej Jerozolimy. Składa się ona z 366 części (= „czytań”; s. 1–366), poprzedzonych: Spisem treści (s. VI–XII), Graficznym spisem treści (s. XIII–XX) oraz krótkim Wstępem (s. XXI–XXVI). Oczywiście, by nie rozsadzić ram niniejszej recenzji, ich wszystkie tytuły nie zostaną wymienione, a co za tym idzie, rozdziały te nie zostaną zrecenzowane jeden po drugim. Jak zatem będzie wyglądała niniejsza recenzja? Otóż ograniczy się jedynie do zagadnień ogólnych: literackich i teologicznych.
APPLICATION OF JOB SAFETY ANALYSIS IN COPPER MINING OPERATIONS: A REVIEW
Authors: Ntengwe F.W. , Manda E. , Chisakulo E. , Mwanabute N. , Lungu M. 
Published: February 2025

Job Safety (JS) is an important element in people’s lives in the copper-mining world despite risk challenges. The main challenges are the hazards and risks. The purpose of the study was to establish whether the application of Job Safety analysis (JSA) could be a meaningful approach to evaluating the dangers that impinge on job safety. The purpose job explanation, the physical inspection, qualitative and quantitative risk assessment methods were used. The results showed that a probability above 80% (81<X<100%) meant that the JS in that job step needed an urgent review. The probability below 20% (20>X>0%) meant that the impact was trivial. The probabilities between 21 to 40% showed that the impact was low and a decision can be judged by experience while that from 41 to 60 meant a medium impact and the decision could also be based on experience while that from 61 to 80% meant that the impact was severe and attention was needed to the process. The areas that required urgent review, based on quantitative risk were in blasting, electricity, dust particles and ventilation with risk ratings of 88.2, 64.8, 16 and 12.8 % respectively. Based on qualitative risks, areas that required review include blasting (12.6 %), electricity (10.8 %) and dust particles (4.2 %). Therefore, the study emphasized that integrating JS and JSA with proactive hazard identification and mitigation could reduce workplace incidents. Involving the workforce and maintaining continuous feedback ensures JSA evolves with changing risks, enhancing safety culture and reducing accidents.
Effective Projection of Quality of Working Life (QWL) using Emotional Intelligence (EI) of Management Teachers in India through Structural Equation Modelling (SEM)
Authors: Dr. L. Gandhi  
Published: February 2025

This study seeks to project the Quality of working life using Emotional Intelligence, as well as to support the proposed model. The descriptive research design was used as the researcher intends to know how and why EI influences QWL. The faculty members who are associated with management colleges in Coimbatore, Tamilnadu were the Population for the study. 480 faculty members were selected as samples using a convenient sampling method. To collect primary information, the Simon Easton and Darren Van Laar QWL, as well as the Mayer, Caruso, and Salovey EI scale, were used. In this work, ANOVA, regression, correlation, and Structural Equation Modeling (SEM) were employed to investigate dependability and test the conceptual model. In this article, the researcher discovered that Emotional Intelligence was an important predictor of management teachers' Quality of Work Life. It is reasonable to conclude that the greater the EI, the better the QWL. Specifically, as an individual's EI grows, they become more aware of the complexities of managing QWL. Hence, it is suggested to the faculty members with less experience to get mentored by the senior members to learn the art of managing stress and in turn, enhance their job and career satisfaction. There was a strong association between job experience and EI attributes such as emotional perception, understanding, and managing emotions. It is suggested to the management faculty who are in the initial days of their careers to consult the experienced faculty, especially for emotional dilemmas. Even though discussing the emotional issues with the senior members helps allow their emotions to travel to the neocortex from the limbic brain for making rational decisions.
ШЪЫПКЪИШЪ (СТО ИСТИН) В АДЫГСКОЙ ПАРЕМИОЛОГИИ: СТРУКТУРА И ФУНКЦИИ
Authors: Унарокова Р.Б. , Темзокова Р.С. 
Published: February 2025

Рассматривается одна из малоизученных жанровых форм адыгского фольклора – шъыпкъишъ (сто истин). Анализируются ее специфические особенности, определяются структура жанра, количественные и качественные показатели. Выделяется два типа истин: односложные формулы с прямой мотивировкой значения и относительно закрытые конструкции, в которых пары противопоставлений связываются смысловым параллелизмом. Устанавливается, что шъыпкъишъ (сто истин) – это паремическая тирада, имеющая цепевидную композицию, состоящую из относительно автономных единиц, связанных друг с другом подхватной (эховой) рифмой.
The article considers one of the little-studied genre forms of Adyghe folklore – one hundred truths, analyzing its specific features. It determines the structure of the genre, quantitative and qualitative indicators. Two types of truths are distinguished: monosyllabic formulas with direct motivation of meaning and relatively closed constructions in which pairs of opposites are connected by semantic parallelism. It is established that one hundred truths is a paremic tirade with a chain-like composition consisting of relatively autonomous units connected with each other by a catching (echo) rhyme.