bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cross‐generational trans fat intake modifies BDNF mRNA in the hippocampus: Impact on memory loss in a mania animal model
Authors: Trevizol Fabíola , Dias Verônica T. , Roversi Katiane , Barcelos Raquel C.S. , Kuhn Fábio T. , Roversi Karine , Pase Camila S. , Golombieski Ronaldo , Veit Juliana C. , Piccolo Jaqueline , Emanuelli Tatiana , Rocha João B.T. , Bürger Marilise E. 
Published: November 2014

ABSTRACTRecently, we have described the influence of dietary fatty acids (FA) on mania‐like behavior of first generation animals. Here, two sequential generations of female rats were supplemented with soybean oil (SO, rich in n‐6 FA, control group), fish oil (FO, rich in n‐3 FA) and hydrogenated vegetable fat (HVF, rich in trans FA) from pregnancy and during lactation. In adulthood, half of each group was exposed to an amphetamine (AMPH)‐induced mania animal model for behavioral, biochemical and molecular assessments. FO supplementation was associated with lower reactive species (RS) generation and protein carbonyl (PC) levels and increased dopamine transporter (DAT) levels, while HVF increased RS and PC levels, thus decreasing catalase (CAT) activity and DAT levels in hippocampus after AMPH treatment. AMPH impaired short‐ (1 h) and long‐ (24 h) term memory in the HVF group. AMPH exposure was able to reduce hippocampal BDNF‐ mRNA expression, which was increased in FO. While HVF was related to higher trans FA (TFA) incorporation in hippocampus, FO was associated with increased percentage of n‐3 polyunsaturated FA (PUFA) together with lower n‐6/n‐3 PUFA ratio. Interestingly, our data showed a positive correlation between brain‐derived neurotrophic factor (BDNF) mRNA and short‐ and long‐term memory (r2 = 0.53; P = 0.000/r2 = 0.32; P = 0.011, respectively), as well as a negative correlation between PC and DAT levels (r2 = 0.23; P = 0.015). Our findings confirm that provision of n‐3 or TFA during development over two generations is able to change the neuronal membrane lipid composition, protecting or impairing the hippocampus, respectively, thus affecting neurothrophic factor expression such as BDNF mRNA. In this context, chronic consumption of trans fats over two generations can facilitate the development of mania‐like behavior, so leading to memory impairment and emotionality, which are related to neuropsychiatric conditions. © 2014 Wiley Periodicals, Inc.
Retracted: Mitochondrial protein acetylation mediates nutrient sensing of mitochondrial protein synthesis and mitonuclear protein balance
Authors: Di Domenico Antonella , Hofer Annette , Tundo Federica , Wenz Tina 
Published: November 2014

The above article, published online on November 15, 2014 in Wiley Online Library (wileyonlinelibrary.com), has been retracted by agreement between the journal's Editors‐in‐Chief, Angelo Azzi and William J. Whelan, Corresponding Author Tina Wenz, the University of Cologne, and Wiley Periodicals, Inc. The article has been retracted on request of the University of Cologne that, after an investigation, established that the data reported in it are not reproducible.Note from the Corresponding Author: “The paper reports on the influence of mitochondrial acetylation on protein synthesis. After publication, several irregularities appeared and have been thoroughly investigated by the lab of the Corresponding Author in cooperation with the commission of Research integrity of the University of Cologne. Both came to the conclusion that data used for the publication are erroneous and that the presented data are not reproducible by the lab of the Corresponding Author and other labs. The Corresponding Author takes responsibility and regrets not having detected these issues before publication. The appropriate corrective action is retraction of the paper. The Corresponding Author apologizes to the scientific community.”Reference

Antonella Di Domenico,
Annette Hofer,
Federica Tundo,
Tina Wenz (2014), , IUBMB Life. 66: 793–802, 2014. DOI: 10.1002/iub.1328
Holocene environments and prehistoric site patterning in the Victorian Mallee
Authors: Ross A. 
Published: November 2014

AbstractNorth‐western Victoria is a semi‐arid region of low sand dunes and dense mallee vegetation cover. Except for possible hearth sites in Pleistocene deposits at Lake Tyrrell, Aboriginal occupation of this area, known as ‘the Mallee’, does not appear to have occurred until the terminal Pleistocene/early Holocene, when the region was much less arid than at present. Occupation then was restricted to the northern part of the Mallee; more widespread occupation did not occur until long after the favourable conditions of the Holocene ended. The later occupation was probably triggered by an increase in population in inland south‐western Victoria.
Islands in the interior: a model for the colonization of Australia's arid zone
Authors: Veth Peter 
Published: November 2014

AbstractA colonization model is proposed to explain the timing of human occupation in different regions of the arid zone and the reasons for inferred demographic changes through time. A biogeographic approach views changes in human economy and technology against the backdrop of climatic oscillations of the last 40,000 years. This model stands in strong contrast to that of the ‘conservative desert culture’ proposed by Gould, which has become untenable as data from arid zone excavations are increasingly argued to reflect significant changes in human economy, technology and demography through time. The results of regional survey and excavation from the Pilbara and sandy deserts of north‐west Australia, from central Australia, the Flinders Ranges and adjacent dunefields and from semi‐arid Queensland suggest that the occupation of the arid zone from the late Pleistocene on is likely to have been a highly dynamic process. The notion of a stable human adaptation to the diverse landforms and environments of the arid zone finds little support in the archaeological record.
The case for a resident human population in the Central Australian Ranges during full glacial aridity
Authors: Smith M.A. 
Published: November 2014

AbstractThe full glacial climate was marked by enhanced aridity, suggesting that there would be no human occupation of the interior of the continent at the glacial maximum. However, evidence from Puritjarra Rockshelter shows that the Central Australian Ranges continued to be occupied between 22,000 and 13,000 BP. The repeated use of Puritjarra, together with its location away from any natural corridor for travel into the region, indicates the presence of a resident local population. The archaeological evidence is complemented by a model of human ecology in Central Australia at 18,000 BP, showing that there is no a priori reason for expecting the region to have been totally abandoned during the last glacial maximum.
Chronology and explanation in western Victoria and south‐east South Australia
Authors: Bird C.F.M. , Frankel David 
Published: November 2014

AbstractArchaeological evidence from western Victoria and southeast South Australia has been used to develop models of late Holocene change. In this paper we reassess some of the primary data, concentrating on radiocarbon dates available from over eighty sites in the area. A general methodological critique and discussion of each different site‐type exposes fundamental problems in establishing a basic sequence and demonstrating the nature of change. An argument is put forward that late Holocene developments in this area are the latest in a continuous series, and do not require the special explanation of ‘intensification‘.
Detection of amorphous alumino‐silicate by X‐ray diffraction and chemical analysis to detect firing in archaeological sediments
Authors: Singh Balwant , O'Connor Sue , Veth Peter , Gilkes Robert 
Published: November 2014

AbstractFire modifies sediments and soil by converting some crystalline clay minerals to amorphous alumino‐silicate minerals that can be determined using a combination of X‐ray diffraction and chemical analysis procedures. Recognition of these materials provides a test for occupation that is independent of, and complementary to, criteria based on the occurrence of cultural or magnetic properties of sediments. This novel procedure has been evaluated for artificial mineral mixtures heated in simulated hearth fires and for Pleistocene and Holocene sediments from caves in the Kimberley Region of Western Australia. An index based on amorphous Al in the samples has been developed to separate heated and unheated samples.
Ascent to the sky. A shamanic initiatory engraving from the Burrup Peninsula, northwest Western Australia
Authors: Sales Kim 
Published: November 2014

AbstractA ‘neuropsychological model’ has been proposed which links rock art production with shamanistic experiences whilst in altered states of consciousness. The model claims universality, and hence this paper seeks to apply it to a rock art panel from the Pilbara region, Western Australia, in an assessment of its utility. Evidence of shamanism as practiced in Australia is gleaned from the ethnographic literature, entoptic motifs are identified in Australian rock art and an interpretation of the particular panel is advanced in the light of this. The potential of the model to amplify our understanding of Australian rock art is indicated.
The timing and nature of prehistoric island use in northern Australia
Authors: O'Connor Sue 
Published: November 2014

AbstractThis paper presents new data for island use in the north west of Australia. The data from High Cliffy Shelter indicate that there are significant similarities in the prehistoric use of islands between northeast and northwest Australia. These findings have implications for previous theories regarding the impetus for initial offshore island use in north east Australia. Furthermore, it is argued that the pattern of offshore island use in northern Australia can be differentiated from island use in southern Australia. Reasons for this variability are examined
How old are subspecies?: A tiger's eye‐view of human evolution
Authors: Groves Colin P. 
Published: November 2014

Abstract‘Replacement’ and ‘Regional Continuity’ models of Homo sapiens evolution are still subject to lively debate, but the human case has been discussed without reference to what happens in other animals. It happens that some large mammal species have fossil records that are good enough to permit, to some degree, the history of their subspeciation and of their mode of origin. With one rather dubious exception, there is no case of Regional Continuity. Some can be demonstrated to originate from their parent species and then subspeciate; subspecies may evolve and continue in situ, or there may be a complicated pattern of intra‐species replacements.Many of the species concerned are rare or endangered, and have been subject to genetic studies directed towards captive management. Genetic distances tend to correlate poorly with known or inferred fossil information; except for the White Rhinoceros the separation time of the two living subspecies as calculated from mtDNA is consistent with the fossil record.The implications of this for human evolution are discussed.
Cowrie shell tools: fact or fiction?
Authors: Spennemann Dirk H.R. 
Published: November 2014

AbstractFragmented cowrie shells found in Oceanic archaeological sites are very often interpreted as artefacts. This paper investigates the ethnographic record of documented uses of cowrie shells and compares the archaeological record. Based on experimental data an argument is advanced that some of the observed breakage is due to biogenic causes based on shell structure rather than on intentional anthropogenic action.
Palaeoenvironmental evidence for human settlement of New Caledonia
Authors: Stevenson Janelle , Dodson John R. 
Published: November 2014

AbstractHuman occupation sites dating back to the late Pleistocene have been uncovered in the Bismarck Archipelago and northern Solomon Islands. Beyond this region to the east, however, no archaeological site pre‐dates 3500 BP. This dramatic discontinuity in time raises the question of whether an earlier migration beyond the Solomons may have taken place and it is this possibility that has been examined for New Caledonia. Sediment from Saint Louis Lac in the south of the main island was analysed for indirect indicators of human impact. Changes in charcoal influx and vegetation indicative of disturbance (ferns and grass) were examined. These were analysed in conjunction with the site's changing stratigraphy, sedimentation rates and mineral magnetic properties. Grass pollen and fern spores abruptly increase around 3000 BP which corresponds with a significant change in charcoal influx. Human activity, within the vicinity of Saint Louis Lac, is therefore interpreted as commencing around 3000 BP, a finding in close accordance with New Caledonia's current archaeological record.
Late Pleistocene behavioural variation and time trends: the case from Tasmania
Authors: Cosgrove Richard 
Published: November 2014

AbstractThe newly discovered archaeological site of Parmerpar Meethaner, located in the Forth River valley Tasmania, is described. This important site, 1) has evidence of repeated long term human occupation extending from c.780 BP to c.34,000 BP, 2) crosses all the major large scale climatic events such as the beginning, middle and end of the LGM and the late Pleistocene/Holocene boundary, 3) supports the notion that Tasmania was first occupied 35,000 radiocarbon years ago, 4) has a different settlement history to sites in Southwest Tasmania, and 5) provides the missing archaeological evidence of human responses to changing forested conditions. The paper describes the material from Parmerpar Meethaner and examines how they fit with what is currently known about late Pleistocene Tasmanian occupation in terms of dating patterns of discard behaviour, Bass Strait landbridges and colonising events.
Seriation as a method of chronologically ordering architectural design traits: an example from Hawai'i
Authors: Graves Michael W. , Cachola‐Abad C. Kēhaunani 
Published: November 2014

AbstractSeriation, a relative dating method, can be employed to chronologically order traditional Hawaiian religious sites (known as heiau) in terms of their masonry architectural traits. This method is applied to 107 heiau identified and recorded on the island of Maui. By first separating the sites into four different geographic zones and then constructing seriations for each zone, the potential temporal orders of the seriations can be compared. Radiocarbon dates from the final construction episodes at a number of sites are available and these correspond with the relative order of heiau for windward and leeward regions of the island. Seriation is a cost effective dating method that is also relatively precise. Finally, we evaluate the seriations of Maui heiau against hypotheses which stipulate design change and the introduction of new religious architecture from central East Polynesia.
Recent developments in the study of New Caledonia's prehistory
Authors: Sand Christophe 
Published: November 2014

AbstractSince the 1960's and 1970's, a number of archaeological overviews associating chronological evolution and cultural transformation in Oceanian archipelagos have been published (Yen and Gordon 1973; Kirch and Yen 1982; Best 1984; Davidson 1984; Kirch 1985, 1988b). These works are often based on determinist and evolutionist concepts (Kirch 1984) which, over and above typological elements such as the evolution of pottery and hook forms, take into consideration other factors such as the slow human colonisation of islands, population growth, human influence on the environment, occupation of the land and division into different social and political areas, and the intensification of horticultural crops.This type of global approach to the reconstitution of prehistoric chronology has recently been attempted in New Caledonia (Sand 1994a, 1995c). It focussed on the progressive colonisation of most of the ecological zones on the Grande Terre and the Loyalty Islands, as well as the constraints placed on people by the natural environment, in an attempt, amongst other things, to understand the origins and validity of the social mechanisms presented in anthropological studies. In a recent article, Kirch and Lepofsky summarised in one sentence the view that most archaeologists share with regard to the prehistory of this Southern Melanesian archipelago ‘the antiquity of New Caledonian terracing technology thus remains wholly enigmatic (not unlike other aspects of the island's prehistory!)’. Despite the Grande Terre (Mainland) of New Caledonia, the largest of the Pacific Islands, being the focus of attention for the first generation of archaeologists studying Oceania (Gifford and Shutler 1956, Golson 1962), archaeological research has never really taken off in New Caledonia. Yet prehistoric vestiges are an integral part of the landscape: three thousand years of pre‐European Oceanian populations modelled and shaped the very depths of inhabitable valleys, scattering house mounds along ridges and petroglyph sites beside creeks, taro pondfields as far as the eye can see across the hills as well as frequently renewed occupancy along beaches.The aim of this article is to present some new data obtained through recent research by the Archaeology Department of New Caledonia. Attention will focus first on the beginnings of Austronesian populations, the evolution of ceramic traditions and various other aspects of material culture, before analysing the evolution of settlement patterns and the variety of horticultural structures. The ensuing discussion reconsiders certain sociocultural factors, offering a different view of sociocultural dynamics throughout the pre‐European history of the New Caledonian archipelago.
Ancient lead weight found with Loisels Pumice near Hook Point, Fraser Island, Queensland
Authors: Ward W.T. , Little I.P. , Roberts G.M. , Gulson B.L. , O'Leary B.M. , Price D.M. 
Published: November 2014

AbstractA lead weight was recovered between 2.2 and 2.4 m depth in stranded beach sands at the southern end of Fraser Island. Its isotope values indicate a close affinity with lead from mines in France. Pumice found with the lead occurs elsewhere at sites dated 480±100 y BP and 520±75 y BP, and one fragment appears to be Loisels Pumice, for which a similar radiocarbon age has been reported from New Zealand. The data are difficult to assess but suggest that the lead weight could have reached this ancient beach between 1410 and 1630 AD.
Minimum ages for pecked rock markings from Jinmium, north western Australia
Authors: Watchman Alan , Taçon Paul , Fullagar Richard , Head Lesley 
Published: November 2014

AbstractSixteen accelerator mass spectrometry (AMS) radiocarbon (14C) determinations for oxalate crusts overlying three pecked rock markings (cupules) at three separate localities in the Keep River area of north western Australia provide age estimates from 1430–11,000 years since the markings were last retouched. These are the first direct dates reported for rock‐art of this kind. While these determinations do not lend strong support to previous arguments for a Pleistocene cupule age they also do not refute such arguments. We maintain the age of the crusts is more closely related to climatic fluctuations rather than when cupules were produced, with crust formation directly related to the nature of local ecological conditions. We discuss implications for estimating the time‐depth of rock‐art sequences in northern Australia, and general problems with the direct dating of rock‐art.
In vitro and in vivo evaluation of capsaicin‐loaded microemulsion for enhanced oral bioavailability
Authors: Zhu Yuan , Zhang Jiajia , Zheng Qianfeng , Wang Miaomiao , Deng Wenwen , Li Qiang , Firempong Caleb Kesse , Wang Shengli , Tong Shanshan , Xu Ximing , Yu Jiangnan 
Published: November 2014

AbstractBACKGROUNDCapsaicin, as a food additive, has attracted worldwide concern owing to its pungency and multiple pharmacological effects. However, poor water solubility and low bioavailability have limited its application. This study aims to develop a capsaicin‐loaded microemulsion to enhance the oral bioavailability of the anti‐neuropathic‐pain component, capsaicin, which is poorly water soluble.RESULTSIn this study, the microemulsion consisting of Cremophor EL, ethanol, medium‐chain triglycerides (oil phase) and water (external phase) was prepared and characterized (particle size, morphology, stability and encapsulation efficiency). The gastric mucosa irritation test of formulated capsaicin was performed in rats to evaluate its oral feasibility, followed by the pharmacokinetic study in vivo. Under these conditions, the encapsulated capsaicin revealed a faster capsaicin release in vitro coupled with a greater absorption in vivo when compared to the free capsaicin. The oral bioavailability of the formulated capsaicin‐loaded microemulsions was 2.64‐fold faster than that of free capsaicin. No significant irritation was observed on the mucosa from the pathological section of capsaicin‐loaded microemulsion treated stomach.CONCLUSIONThese results indicate that the developed microemulsion represents a safe and orally effective carrier for poorly soluble substances. The formulation could be used for clinical trials and expand the application of capsaicin. © 2014 Society of Chemical Industry
Selective efficacy of zoledronic acid on metastasis in a patient‐derived orthotopic xenograph (PDOX) nude‐mouse model of human pancreatic cancer
Authors: Hiroshima Yukihiko , Maawy Ali A. , Katz Matthew H.G. , Fleming Jason B. , Bouvet Michael , Endo Itaru , Hoffman Robert M. 
Published: November 2014

Background and ObjectivesPatient‐derived orthotopic xenograft (PDOX) nude‐mouse models replicate the behavior of clinical cancer, including metastasis. The objective of the study was to determine the efficacy of zoledronic acid (ZA) on metastasis of a patient‐derived orthotopic xenograft (PDOX) nude‐mouse model of pancreatic cancer.MethodsIn the present study, we examined the efficacy of ZA on pancreatic cancer growth and metastasis in a PDOX nude‐mouse model.ResultsZA monotherapy did not significantly suppress primary tumor growth. However, the primary tumor weight of gemcitabine (GEM) and combination GEM + ZA‐treated mice was significantly decreased compared to the control group (GEM: P = 0.003; GEM + ZA: P = 0.002). The primary tumor weight of GEM + ZA‐treated mice was significantly decreased compared to GEM‐treated mice (P = 0.016). The metastasis weight decreased in ZA‐ or GEM‐treated mice compared to the control group (ZA: P = 0.009; GEM: P = 0.007. No metastasis was detected in combination GEM + ZA‐treated mice compared to the control group (GEM + ZA; P = 0.005).ConclusionsThe results of the present study indicate that ZA can selectively target metastasis in a pancreatic cancer PDOX model and that the combination of ZA and GEM should be evaluated clinically in the near future for this highly treatment‐resistant disease. J. Surg. Oncol. 2015 111:311–315. © 2014 Wiley Periodicals, Inc.
Protein Compatibility of Selected Cross‐linking Reactions for Hydrogels
Authors: Hammer Nadine , Brandl Ferdinand P. , Kirchhof Susanne , Messmann Viktoria , Goepferich Achim M. 
Published: November 2014

AbstractThe compatibility of selected cross‐linking reactions with lysozyme is investigated. Michael‐type additions of nucleophilic amino acids to maleimide, vinyl sulfone and acrylamide groups are detected by gel electrophoresis. The degree of modification depends on the polymer and the pH. Complete modification with more than five PEG chains is observed after incubation with mPEG5k‐vinyl sulfone at pH 9, whereas 96% of the protein remains unmodified after incubation with mPEG5k‐acrylamide at pH 4. Incubation with mPEG5k‐thiol results in thiol‐disulfide exchange reactions. Hydrogel preparation is simulated by using polymer mixtures. Protein modifications are detected, which may affect the protein structure, decrease activity and bioavailability, and increase the risk for immune responses.