bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oops!… I waited until the last minute again: The role of fresh start nudges in task completion
Authors: Min Kyeong Sam , Min Dong‐Jun (DJ) , Tadesse Amanuel , Kemp Elyria 
Published: August 2024

AbstractIndividuals often have difficulties completing tasks in a timely manner. Whether it be scheduling a doctor's appointment, purchasing a birthday gift, or booking an airline ticket, waiting until the very last minute can carry serious consequences. In two experimental studies, we explore how individuals can be encouraged to finish tasks promptly. We provide evidence for the “fresh start effect” by showing that a temporal landmark signaling a new beginning helps speed up their task completion. Notably, we demonstrate that the “fresh start nudge” can facilitate early task completion through the underlying processes of meaningfulness and motivation. We also report the moderating role of task openness, supporting the claim that the fresh start effect is stronger when the task is perceived to be relatively closed (rather than open) and must therefore be completed in fewer steps without interruption.
Synergistically Regulating CBD‐SnO2/Perovskite Buried Interface for Efficient FAPbI3 Perovskite Solar Cells
Authors: Liu Zhenghao , Li Yiming , Chen Zijing , Tan Chengyu , Du Xiangjin , Tian Fubo , Shi Jiangjian , Wu Huijue , Luo Yanhong , Li Dongmei , Meng Qingbo 
Published: August 2024

AbstractTin oxide (SnO2) based on chemical bath deposition method (CBD‐SnO2) is considered as an ideal electron transporting layer for perovskite solar cells (PSCs), however, the research on precise regulation toward CBD‐SnO2 layer is lacking. Here, the study introduces a multifunctional molecule, potassium 2‐(N‐morpholino)ethanesulfonate (MES‐K), on the surface of CBD‐SnO2 layer to synergistically modify the buried interface between the SnO2 and perovskite. It is found that MES‐K introduction can passivate interfacial defects, favor the perovskite crystal growth, and improve carrier transportation. 25.14% efficiency of small‐size perovskite solar cells has been achieved with 24.45% efficiency of 1 cm2 perovskite devices, with negligible hysteresis. Besides, unencapsulated devices based on CBD‐SnO2 can maintain > 95% of its initial efficiency after 2000 h storage at ambient environment, and > 90% after 1000 h LED illumination.
Electrochemiluminescence Lateral Flow Immunoassay Using Ruthenium(II) Complex‐Loaded Dendritic Mesoporous Silica Nanospheres for Highly Sensitive and Quantitative Detection of SARS‐CoV‐2 Nucleocapsid Protein
Authors: Fu Wenxuan , Wang Xuexue , Ying Xudong , Sun Tao , Wang Yafeng , Wang Jing , Su Bin 
Published: August 2024

AbstractLateral flow immunoassays (LFIA) are widely used for the cost‐effective and rapid detection of diverse analytes. However, traditional LFIA suffers from difficulties in providing quantitative results and has low sensitivity. Herein, LFIA is combined with electrochemiluminescence (ECL), a leading transduction technique with high sensitivity and wide dynamic range, to achieve highly sensitive and quantitative detection of severe acute respiratory syndrome coronavirus nucleocapsid protein (SARS‐CoV‐2 N protein). Ruthenium(II)‐based complexes are synthesized and loaded into dendritic mesoporous silica nanospheres (PEI‐Ru/dSiO2), which possessed central‐radial pore channels and served as tags for ECL‐LFIA. The electrodes are fabricated on a nitrocellulose (NC) membrane, which simplifies the structure of the ECL‐LFIA. PEI‐Ru/dSiO2 is captured on the electrode surface via a sandwich immunoreaction, which enhances the ECL signal by decreasing the distance between PEI‐Ru/dSiO2 and the electrode surface. Using 2,2‐bis(hydroxymethyl)‐2,2′,2′'‐nitrilotriethanol (BIS‐TRIS) as coreactant, the ECL‐LFIA is used for detecting SARS‐CoV‐2 N protein, with a linear range of 1–104 ng mL−1 and a limit of detection (LOD) of 0.52 ng mL−1. ECL‐LFIA can also be used to detect analytes in complex matrices. These results demonstrate that the prepared ECL‐LFIA has great potential as a point‐of‐care testing platform for the rapid and quantitative detection of disease biomarkers.
Retina‐Like Chlorophyll Heterojunction‐Based Optoelectronic Memristor with All‐Optically Modulated Synaptic Plasticity Enabling Neuromorphic Edge Detection
Authors: Jiang Jian , Shan Xuanyu , Xu Jiaqi , Sun Yuting , Xiang Tian‐Fu , Li Aijun , Sasaki Shin‐ichi , Tamiaki Hitoshi , Wang Zhongqiang , Wang Xiao‐Feng 
Published: August 2024

AbstractOptoelectronic memristors, which possess the potential capacities of in‐sensor computing, promote the development of highly efficient neuromorphic vision. In this work, a novel optoelectronic memristor based on chlorophyll (Chl) heterojunction is proposed, which consists of two types of Chl derivatives (zinc methyl 3‐devinyl‐3‐hydroxymethyl‐pyropheophorbide‐a and methyl 131‐deoxo‐131‐dicyanomethylene‐pyropheophorbide‐a). Chl heterojunction improves the optoelectronic performance of the device due to its ability to efficiently separate photogenerated electron‐hole pairs. The device exhibits the synaptic potentiation and inhibition behaviors under light stimulations of 430 and 730 nm, respectively, thus demonstrating the all‐optically modulated synaptic plasticity. The switching mechanism can be attributed to the photo‐ionization/deionization of oxygen vacancies at the zinc oxide (ZnO)/Chl interface. In addition, the image pre‐processing functions of contrast enhancement and noise reduction are implemented in a memristive array. In particular, the edge detection function has been implemented by utilizing reversible optical modulation, which highlights the object outline. The optoelectronic memristor based on the Chl heterojunction proposed here provides a promising foundation for advancing neuromorphic vision.
Functional Binder with Enhanced Chemical Adsorption for Black Phosphorus Anode in Lithium‐Ion Capacitors
Authors: Liu Ke Wei , Ma Yi Bo , Guo Yang , Wang Hao , Xu Ya Nan , Zhang Xu Dong , Zhang Xiong , Sun Xian Zhong , Wang Kai , Yu Le , Ma Yan Wei 
Published: August 2024

AbstractBlack phosphorus (BP) has been recognized as an ideal anode material for fast‐charging lithium (Li)‐ion capacitors (LICs) due to its high theoretical capacity (2596 mAh g−1), appropriate lithiation potential (0.7 V vs Li+/Li) and fast ion diffusion capability. However, large volume change and soluble polyphosphides (LixPs)‐based intermediates during charging‐discharging process seriously deteriorate cycling performance. To address the aforementioned issues, an elaborated design is reported on the binder for BP electrode. The ‐NH2 polar functional group in grafted chitosan (GCS) binder presents strong chemical anchoring effect for both BP and soluble LixPs, achieving superior adhesion force and LixPs constraining capability for enhanced structure integrity of BP electrode. In addition, GCS exhibits strong Li‐ion binding energy that promotes the Li‐ion adsorption at electrode level, leading to a boosted cycle life for BP. As a result, the graphene (G) incorporated BP electrode using GCS binder shows specific capacity of 997.6 mAh g−1 after 400 cycles at 1 A g−1. This study unravels the crucial role of functional groups for binder in high‐performance BP electrode.
An In Vitro Model of the Blood–Brain Barrier for the Investigation and Isolation of the Key Drivers of Barriergenesis
Authors: Schofield Christina , Sarrigiannidis Stylianos , Moran‐Horowich Alejandro , Jackson Emma , Rodrigo‐Navarro Aleixandre , van Agtmael Tom , Cantini Marco , Dalby Matthew J. , Salmeron‐Sanchez Manuel 
Published: August 2024

AbstractThe blood–brain barrier (BBB) tightly regulates substance transport between the bloodstream and the brain. Models for the study of the physiological processes affecting the BBB, as well as predicting the permeability of therapeutic substances for neurological and neurovascular pathologies, are highly desirable. Existing models, such as Transwell utilizing‐models, do not mimic the extracellular environment of the BBB with their stiff, semipermeable, non‐biodegradable membranes. To help overcome this, we engineered electrospun membranes from poly L‐lactic acid in combination with a nanometric coating of poly(ethyl acrylate) (PEA) that drives fibrillogenesis of fibronectin, facilitating the synergistic presentation of both growth factors and integrin binding sites. Compared to commercial semi‐porous membranes, these membranes significantly improve the expression of BBB‐related proteins in brain endothelial cells. PEA‐coated membranes in combination with different growth factors and extracellular protein coatings reveal nerve growth factor (NGF) and fibroblast growth factor (FGF‐2) caused formation of better barriers in vitro. This BBB model offers a robust platform for studying key biochemical factors influencing barrier formation that marries the simplicity of the Transwell model with the highly tunable electrospun PEA‐fibronectin membranes. This enables the generation of high‐throughput drug permeability models without the need of complicated co‐culture conditions.
A Photoactivated Self‐Assembled Nanoreactor for Inducing Cascade‐Amplified Oxidative Stress toward Type I Photodynamic Therapy in Hypoxic Tumors
Authors: Luo Xuan , Jiao Qishu , Pei Shicheng , Zhou Shuyao , Zheng Yaxin , Shao Weiyang , Xu Keming , Zhong Wenying 
Published: August 2024

AbstractType I photodynamic therapy (PDT) generates reactive oxygen species (ROS) through oxygen‐independent photoreactions, making it a promising method for treating hypoxic tumors. However, the superoxide anion (O2∙–) generated usually exhibits a low oxidation capacity, restricting the antitumor efficacy of PDT in clinical practice. Herein, a photoactivated self‐assembled nanoreactor (1‐NBS@CeO2) is designed through integration of type I PDT and cerium oxide (CeO2) nanozymes for inducing cascade‐amplified oxidative stress in hypoxic tumors. The nanoreactor is constructed though co‐assembly of an amphiphilic peptide (1‐NBS) and CeO2, giving well‐dispersed spherical nanoparticles with enhanced superoxide dismutase (SOD)‐like and peroxidase (POD)‐like activities. Following light irradiation, 1‐NBS@CeO2 undergoes type I photoreactions to generated O2∙–, which is further catalyzed by the nanoreactors, ultimately forming hypertoxic hydroxyl radical (∙OH) through cascade‐amplified reactions. The PDT treatment using 1‐NBS@CeO2 results in elevation of intracellular ROS and depletion of GSH content in A375 cells, thereby inducing mitochondrial dysfunction and triggering apoptosis and ferroptosis of tumor cells. Importantly, intravenous administration of 1‐NBS@CeO2 alongside light irradiation showcases enhances antitumor efficacy and satisfactory biocompatibility in vivo. Together, the self‐assembled nanoreactor facilitates cascade‐amplified photoreactions for achieving efficacious type I PDT, which holds great promise in developing therapeutic modules towards hypoxic tumors.
A Self‐Catalytic NO/O2 Gas‐Releasing Nanozyme for Radiotherapy Sensitization through Vascular Normalization and Hypoxia Relief
Authors: Wang Shuyu , Cheng Miaomiao , Wang Shenghui , Jiang Wei , Yang Feifei , Shen Xiaomei , Zhang Lirong , Yan Xiyun , Jiang Bing , Fan Kelong 
Published: August 2024

AbstractRadiotherapy (RT), essential for treating various cancers, faces challenges from tumor hypoxia, which induces radioresistance. A tumor‐targeted “prosthetic‐Arginine” coassembled nanozyme system, engineered to catalytically generate nitric oxide (NO) and oxygen (O2) in the tumor microenvironment (TME), overcoming hypoxia and enhancing radiosensitivity is presented. This system integrates the prosthetic heme of nitric oxide synthase (NOS) and catalase (CAT) with NO‐donating Fmoc‐protected Arginine and Ru3+ ions, creating HRRu nanozymes that merge NOS and CAT functionalities. Surface modification with human heavy chain ferritin (HFn) improves the targeting ability of nanozymes (HRRu‐HFn) to tumor tissues. In the TME, strategic arginine incorporation within the nanozyme allows autonomous O2 and NO release, triggered by endogenous hydrogen peroxide, elevating NO and O2 levels to normalize vasculature and improve blood perfusion, thus mitigating hypoxia. Employing the intrinsic O2‐transporting ability of heme, HRRu‐HFn nanozymes also deliver O2 directly to the tumor site. Utilizing esophageal squamous cell carcinoma as a tumor model, the studies reveal that the synergistic functions of NO and O2 production, alongside targeted delivery, enable the HRRu‐HFn nanozymes to combat tumor hypoxia and potentiate radiotherapy. This HRRu‐HFn nanozyme based approach holds the potential to reduce the radiation dose required and minimize side effects associated with conventional radiotherapy.
A High Capacity Gas Diffusion Electrode for Li–O2 Batteries
Authors: Jenkins Max , Dewar Daniel , Lagnoni Marco , Yang Sixie , Rees Gregory J. , Bertei Antonio , Johnson Lee R. , Gao Xiangwen , Bruce Peter G. 
Published: August 2024

AbstractThe very high theoretical specific energy of the lithium–air (Li–O2) battery (3500 Wh kg−1) compared with other batteries makes it potentially attractive, especially for the electrification of flight. While progress has been made in realizing the Li–air battery, several challenges remain. One such challenge is achieving a high capacity to store charge at the positive electrode at practical current densities, without which Li–air batteries will not outperform lithium‐ion. The capacity is limited by the mass transport of O2 throughout the porous carbon positive electrode. Here it is shown that by replacing the binder in the electrode by a polymer with the intrinsic ability to transport O2, it is possible to reach capacities as high as 31 mAh cm−2 at 1 mA cm−2 in a 300 µm thick electrode. This corresponds to a positive electrode energy density of 2650 Wh L−1 and specific energy of 1716 Wh kg−1, exceeding significantly Li‐ion batteries and previously reported Li–O2 cells. Due to the enhanced oxygen diffusion imparted by the gas diffusion polymer, Li2O2 (the product of O2 reduction on discharge) fills a greater volume fraction of the electrode and is more homogeneously distributed.
Regulation of Electron Delocalization Region in 2D Heteroligand‐Based Copper‐Organic Framework to Enhance NH4+$ \rm {NH_{4}}{^+}$ Charge Storage
Authors: Lu Hongyu , Hu Jisong , Zhang Kaiqi , Zhang Yu , Jiang Botao , Zhang Miao , Deng Shenzhen , Zhao Jingxin , Pang Huan , Xu Bingang 
Published: August 2024

AbstractThe rechargeable aqueous ammonium ion battery shows great potential in low‐cost energy storage system because of its long life and environmental friendliness. However, most inorganic host materials used in ammonium ion batteries are still limited by slow diffusion kinetics. Herein, it is identified that a 2D heteroligand‐based copper‐organic framework featuring numerous ammonium ion adsorption site in the π‐conjugated periodic skeleton supplies multiple accessible redox‐active sites for high‐performance ammonium storage. Benefitting from the effective regulation of electron delocalization by heteroligand and the inherent hydrogen bond cage mechanism between ammonium ions, the resultant full battery delivers a large specific energy density of 211.84 Wh kg−1, and it can be stably operated for 12000 cycles at 5 A g−1 for over 80 days. This explanatory understanding provides a new idea for the rational design of high‐performance MOF‐based ammonium ion battery cathode materials for efficient energy storage and conversion in the future.
Femtosecond Laser‐Induced Regulation of Photo‐ and Persistent Luminescence of Perovskite Crystals
Authors: Zhu Xuanyu , Wang Ting , Gao Wei , Yu Xue , Liu Haozhe , Yue Yang , Yakovlev Alexey Nikolaevich , Yu Siufung 
Published: August 2024

AbstractManipulation of photoluminescence (PL) and persistent luminescence (PersL) provides a powerful tool for anti‐counterfeiting applications. Here, Sb3+‐doped CsCdCl3 perovskite single crystals (SCs) can be selectively irradiated via utilizing ultra‐fast femtosecond (fs) laser, creating tunable PL colors and PersL duration with high precision. The PL color of the synthesized SCs changes from cyan to orange along with the wavelength of the fs laser, for the successful regulation of the optical procedure from a single‐photon to a two‐photon absorption process. Moreover, an orange PersL of CsCdCl3:Sb3+ SC is observed after being charged with a fs laser, and the corresponding duration time can be feasibly controlled with the pump wavelength. In particular, CsCdCl3:Sb3+ is capable of ultrafast carrier capture (1 s) under fs laser compared to ultraviolet lamp pre‐irradiation enabling a high‐resolution micro‐PersL in photon trapping/de‐trapping modes. These findings not only give a new solution for the fabrication high‐resolution micro‐PL and trajectory‐writing micro‐PersL patterns, but also provide a deep insight to understand the photon–matter interactions.
Leveraging Random Effects in Cistrome‐Wide Association Studies for Decoding the Genetic Determinants of Prostate Cancer
Authors: Shao Mengting , Tian Min , Chen Kaiyang , Jiang Hangjin , Zhang Shuting , Li Zhenghui , Shen Yan , Chen Feng , Shen Baixin , Cao Chen , Gu Ning 
Published: August 2024

AbstractCistrome‐wide association studies (CWAS) are pivotal for identifying genetic determinants of diseases by correlating genetically regulated cistrome states with phenotypes. Traditional CWAS typically develops a model based on cistrome and genotype data to associate predicted cistrome states with phenotypes. The random effect cistrome‐wide association study (RECWAS), reevaluates the necessity of cistrome state prediction in CWAS. RECWAS utilizes either a linear model or marginal effect for initial feature selection, followed by kernel‐based feature aggregation for association testing is introduced. Through simulations and analysis of prostate cancer data, a thorough evaluation of CWAS and RECWAS is conducted. The results suggest that RECWAS offers improved power compared to traditional CWAS, identifying additional genomic regions associated with prostate cancer. CWAS identified 102 significant regions, while RECWAS found 50 additional significant regions compared to CWAS, many of which are validated. Validation encompassed a range of biological evidence, including risk signals from the GWAS catalog, susceptibility genes from the DisGeNET database, and enhancer‐domain scores. RECWAS consistently demonstrated improved performance over traditional CWAS in identifying genomic regions associated with prostate cancer. These findings demonstrate the benefits of incorporating kernel methods into CWAS and provide new insights for genetic discovery in complex diseases.
Molecular Engineering of Porous Fe‐N‐C Catalyst with Sulfur Incorporation for Boosting CO2 Reduction and Zn‐CO2 Battery
Authors: Han Jingwei , Xu Qiang , Rong Jiaxin , Zhao Xue , She Ping , Qin Jun‐Sheng , Rao Heng 
Published: August 2024

AbstractTransition metal‐nitrogen‐carbon (M‐N‐C) catalysts have emerged as promising candidates for electrocatalytic CO2 reduction reaction (CO2RR) due to their uniform active sites and high atomic utilization rate. However, poor efficiency at low overpotentials and unclear reaction mechanisms limit the application of M‐N‐C catalysts. In this study, Fe‐N‐C catalysts are developed by incorporating S atoms onto ordered hierarchical porous carbon substrates with a molecular iron thiophenoporphyrin. The well‐prepared FeSNC catalyst exhibits superior CO2RR activity and stability, attributes to an optimized electronic environment, and enhances the adsorption of reaction intermediates. It displays the highest CO selectivity of 94.0% at −0.58 V (versus the reversible hydrogen electrode (RHE)) and achieves the highest partial current density of 13.64 mA cm−2 at −0.88 V. Furthermore, when employed as the cathode in a Zn‐CO2 battery, FeSNC achieves a high‐power density of 1.19 mW cm−2 and stable charge–discharge cycles. Density functional theory calculations demonstrate that the incorporation of S atoms into the hierarchical porous carbon substrate led to the iron center becoming more electron‐rich, consequently improving the adsorption of the crucial reaction intermediate *COOH. This study underscores the significance of hierarchical porous structures and heteroatom doping for advancing electrocatalytic CO2RR and energy storage technologies.
Association of caffeine consumption with cerebrospinal fluid biomarkers in mild cognitive impairment and Alzheimer's disease: A BALTAZAR cohort study
Authors: Blum David , Cailliau Emeline , Béhal Hélène , Vidal Jean‐Sébastien , Delaby Constance , Buée Luc , Allinquant Bernadette , Gabelle Audrey , Bombois Stéphanie , Lehmann Sylvain , Schraen‐Maschke Susanna , Hanon Olivier ,   BALTAZAR study group
Published: August 2024

AbstractINTRODUCTIONWe investigated the link between habitual caffeine intake with memory impairments and cerebrospinal fluid (CSF) biomarkers in mild cognitive impairment (MCI) and Alzheimer's disease (AD) patients.METHODSMCI (N = 147) and AD (N = 116) patients of the Biomarker of AmyLoid pepTide and AlZheimer's diseAse Risk (BALTAZAR) cohort reported their caffeine intake at inclusion using a dedicated survey. Associations of caffeine consumption with memory impairments and CSF biomarkers (tau, p‐tau181, amyloid beta 1‐42 [Aβ1‐42], Aβ1‐40) were analyzed using logistic and analysis of covariance models.RESULTSAdjusted on Apolipoprotein E (APOE ε4), age, sex, education level, and tobacco, lower caffeine consumption was associated with higher risk to be amnestic (OR: 2.49 [95% CI: 1.13 to 5.46]; p = 0.023) and lower CSF Aβ1‐42 (p = 0.047), Aβ1‐42/Aβ1‐40 (p = 0.040), and Aβ1‐42/p‐tau181 (p = 0.020) in the whole cohort.DISCUSSIONData support the beneficial effect of caffeine consumption to memory impairments and CSF amyloid markers in MCI and AD patients.Highlights
We studied the impact of caffeine consumption in the BALTAZAR cohort.
Low caffeine intake is associated with higher risk of being amnestic in MCI/AD patients.
Caffeine intake is associated with CSF biomarkers in AD patients.
Multifunctional Modification of the Buried Interface in Mixed Tin‐Lead Perovskite Solar Cells
Authors: Sun Xinru , Wu Hongzhuo , Li Zhihao , Zhu Rui , Li Guixiang , Su Zhenhuang , Zhang Junhan , Gao Xingyu , Pascual Jorge , Abate Antonio , Li Meng 
Published: August 2024

AbstractMixed tin‐lead perovskite solar cells can reach band gaps as low as 1.2 eV, offering high theoretical efficiency and serving as base materials for all‐perovskite tandem solar cells. However, instability and high defect densities at the interfaces, particularly the buried surface, have limited performance improvements. In this work, we present the modification of the bottom perovskite interface with multifunctional hydroxylamine salts. These salts can effectively coordinate the different perovskite components, having critical influences in regulating the crystallization process and passivating defects of varying nature. The surface modification reduced traps at the interface and prevented the formation of excessive lead iodide, enhancing the quality of the films. The modified devices presented fill factors reaching 81 % and efficiencies of up to 23.8 %. The unencapsulated modified devices maintained over 95 % of their initial efficiency after 2000 h of shelf storage.