bluuebunny/crossref_metadata_2025_split huggingface dataset:
Sistem Informasi Manajemen Pengelolaan Nilai Siswa pada SMK Hikmah Yapis Jayapura
Authors: Nurhayati Siti , Suharto Emilda , Tonggiroh Mursalim , Sah Andrian 
Published: August 2024

Pengolahan nilai siswa, seperti nilai harian, nilai penilaian tengah semester (PTS) dan nilai Penilaian Akhir Semester (PAS) pada SMK Hikmah masih menggunakan aplikasi Microsoft Excel yang memiliki kekurangan, yakni terformatnya setiap kolom ataupun baris yang ada akan menyebabkan penggabungan nilai dari penambahan materi jika struktur kurikulum berganti, belum terintegrasi dari guru ke guru lainnya membuat pemberian informasi nilai masih menggunakan flash disk sehingga waktu yang dibutuhkan untuk mengolah nilai cukup lama, presensi siswa masih menggunakan buku presensi, aplikasi tidak menyediakan proses pengolahan nilai harian. Maka diperlukan sebuah sistem informasi manajemen nilai siswa yang dapat mengolah semua nilai siswa dengan mengintegrasikan setiap alur pada proses pengolahan nilai siswa. Adapun metode yang digunakan untuk menganalisis permasalahan serta memberikan solusi dari permasalahan tersebut adalah metode PIECES, metode perancangan yang digunakan adalah UML. Dari penelitian ini dihasilkan Sistem Informasi Manajemen Pengelolaan Nilai Siswa yang mengintegrasikan nilai antar guru sehingga dapat mengefektifkan waktu dalam mengolah nilai siswa.
Sistem Informasi Penjualan Hewan Ternak pada Distrik Skanto Kabupaten Keerom
Authors: Jusmawati Jusmawati , Ali Nur Hidayat Muhammad , Tonggiroh Mursalim , Taher Jufri Muhammad 
Published: August 2024

Distrik Skanto merupakan sebuah Distrik yang masuk wilayah administratif dari Kabupaten Keerom, mayoritas penduduknya bekerja sebagai peternak hewan. Namun kondisi penjualan hewan ternak pada Distrik Skanto saat ini masih menggunakan cara tradisional, karena kesulitan mencari pembeli, peternak hanya dapat menjual hewan ternaknya kepada pedagang hewan lokal, yang biasanya akan membeli hewan ternak dengan harga yang rendah. Padahal disisi lain ada sebagian orang juga yang sedang mencari hewan ternak, namun tidak bisa membeli langsung kepada peternak yang ingin menjual ternaknya. Penelitian ini menggunakan metode pengumpulan data yaitu observasi, wawancara dan studi pustaka, menggunakan metode analisis PIECES yang terdiri dari (Performance, Information, Economy, Control, Efficiency, Service), sistem yang akan dibangun adalah pemrograman berorientasi objek sehingga metode perancangan yang cocok digunakan adalah pemodelan Unifield Modelling Language (UML), metode pengembangan sistem yang digunakan adalah Waterfall, pengujian sistem yang digunakan adalah Blackbox. Sistem Informasi penjualan hewan ternak yang dihasilkan dapat memudahkan pengelola dan peternak dalam memanajemen data produk dan mempromosikan hewan ternak yang dimilikinya.
Pengaruh Teknologi Informasi dan Pengalaman Terhadap Pengelolaan Keuangan Pada Usaha Mikro
Authors: Ridwan Effendi  , Aurantia Marina  , Nur Jumriantunnisah  , Ahmad Zarkasih  , Muhammad Zulkarnain  
Published: August 2024

Usaha mikro merupakan usaha yang banyak dilakukan oleh masyarakat saat ini. usaha mikro dilakukan karena berbagai hal, seperti minim modal, tidak memiliki kegiatan, memiliki keinginan untuk memperoleh pendapatan. Walaupun usaha mikro dianggap sangat kecil, akan tetapi bila dikelola dengan baik akan memberikan pendapatan dan dapat berkembang menjadi usaha kecil, menengah maupun usaha skala besar. untuk itu pengelolaan keuangan dapat dipengaruhin oleh berbagai hal seperti teknologi informasi dan juga pengalaman usaha. Tujuan penelitian ini adalah untuk mengetahui pengaruh teknologi informasi dan pengalaman usaha terhadap pengelolaan keuangan pada usaha mikro di Kecamatan Ilir Barat Kota Palembang. Metode penelitian yang digunakan adalah metode kuantitatif dengan sumber data dari kuesioner penelitian. Sementara sampel yang digunakan adalah sebanyak 30 usaha mikro yang merupakan usaha makanan dan telah mengelola keuangan dengan menggunakan teknologi informasi serta memiliki masa usaha lebih dari 5 tahun. teknik analisis data menggunakan regresi linier berganda. Hasil penelitian diperoleh bahwa teknologi informasi dan pengalaman usaha secara parsial dan simultan berpengaruh signifikan terhadap pengelolaan keuangan pada usaha mikro yang ada di Kecamatan Ilir Barat Kota Palembang.
Lokalisierung eines mechanochemischen Bindungsbruchs durch Einbettung des Mechanophors in einen Makrocyclus
Authors: Schütze Doreen , Holz Katharina , Müller Julian , Beyer Martin K. , Lüning Ulrich , Hartke Bernd 
Published: January 2015

AbstractMechanophore besitzen eine mechanisch labile Bindung, die durch eine äußere mechanische Kraft gebrochen werden kann. Mithilfe eines Rasterkraftmikroskops (atomic force microscope, AFM) kann die anliegende Kraft quantitativ gemessen und kontrolliert werden. Hier berichten wir über die Synthese eines Makrocyclus, der den Mechanophor sowie eine aliphatische Kohlenwasserstoffkette enthält, die beim Bindungsbruch im Mechanophor als “Sicherheitsleine” fungiert. Diese Ringöffnungsmechanophoreinheit ist zwischen Polyethylenglykol‐Spacermolekülen eingebettet, um kraftspektroskopische Einzelmolekülstudien zu ermöglichen. Der Längenzuwachs beim Bruch des Mechanophors wird gemessen und mit quantenchemischen Rechnungen verglichen.
Bioinspired Super‐Wettability from Fundamental Research to Practical Applications
Authors: Wen Liping , Tian Ye , Jiang Lei 
Published: January 2015

AbstractEngineered wettability is a traditional, yet key issue in surface science and attracts tremendous interest in solving large‐scale practical problems. Recently, different super‐wettability systems have been discovered in both nature and experiments. In this Review we present three types of super‐wettability, including the three‐dimensional, two‐dimensional, and one‐dimensional material surfaces. By combining different super‐wettabilities, novel interfacial functional systems could be generated and integrated into devices for use in tackling current and the future problems including resources, energy, environment, and health.
Microconfinement effect on gas barrier and mechanical properties of multilayer rigid/soft thermoplastic polyurethane films
Authors: Huang Rongzhi , Chari Priyakrit , Tseng Jung‐Kai , Zhang Guojun , Cox Mark , Maia Joao M. 
Published: January 2015

ABSTRACTIn this article, rigid/soft thermoplastic polyurethane (TPU) films were produced via layer‐multiplying co‐extrusion and the effect of confinement on morphology and gas barrier and mechanical properties is studied. The soft TPU, which is 52% hard‐segment, shows phase separation, while the rigid, 100% hard‐segment TPU exhibits amorphous structures. Even though the viscosity ratio of the two TPUs is over 10 and the elasticity ratio around 100, optical and atomic force microscopies show that a multilayer structure was successfully achieved. Then, the multilayer TPU films were uni‐axially stretched to different amounts of deformations, from 0% to 300%. DSC and WAXS results show that microconfinement occurs during orientation, which causes a significant reduction in oxygen permeability of multilayer TPU films, when stretched at 75%, by comparison to the mono and bi‐layer TPU. The dependence of gas barrier properties on temperature and deformation was also investigated, and a 100% improvement in elongation at break was found when compared to films of the rigid TPU. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41849.
Synthesis of polyacrylonitrile/polystyrene latex particles that contain platinum
Authors: Yang Yuzhen , Daniels Eric S. , Klein Andrew 
Published: January 2015

ABSTRACTStudies on the incorporation of highly dispersed platinum (Pt) nanoparticles into proton‐exchange membrane fuel cells (PEMFC) as a possible catalyst have gained tremendous attention in the past decade. The major obstacle to fully commercialize PEMFCs is the high cost of Pt as the catalyst. In this study, the incorporation of highly dispersed platinum molecules into poly(acrylonitrile) (PAN) or polystyrene (PS)/PAN latex particles was carried out to form a possible a catalyst precursor for fuel‐cell applications. Pt‐containing PAN/PS particles were prepared using miniemulsion polymerization. Both transmission electron microscopy (TEM) and induction coupled plasma (ICP) measurements indicated that Pt salt was encapsulated into PAN/PS copolymer latex particles. In addition, the encapsulation percentages of Pt salt are all above 90% for different PAN/PS ratios. Additional experiments have been carried out to convert these Pt molecules into nanoparticles and will be elaborated upon subsequent studies. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41933
Highly sensitive and selective electrochemiluminescence determination of cholesterol utilizing a functional electrode with a core–shell nanostructure
Authors: Li Wei , Ge Junying , Zhao Changzhi 
Published: January 2015

AbstractA highly sensitive and selective method for the determination of cholesterol is required to evaluate trace amounts of cholesterol in test samples. In this work, selected gold nanoparticles (AuNPs) and 5‐amino‐2‐mercapto‐1,3,4‐thiadiazole (AMT) were used and a thin film of three‐dimensional gold–AMT core–shell nanoparticles (p‐AMT–AuNPs) was prepared using an electrochemical method. Cholesterol oxidase was then bonded to the film surface to give a functional electrode. Based on catalysis by the electrode functionalized for cholesterol and a luminol–H2O2 electrochemiluminescence (ECL) system, a highly sensitive and selective ECL method was developed for the determination of cholesterol. Under optimized conditions, ECL intensity showed a good linear relationship with cholesterol over the concentration range 0.05–11.0 µg/ml, with a correlation coefficient of 0.999 and a limit of detection of 0.02 µg/ml. The proposed method was used to determine cholesterol in dairy products with a relative standard deviation of < 1.8% and recovery rates of 98.1–104%. Copyright © 2015 John Wiley & Sons, Ltd.
NF‐κB, CRE and YY1 elements are key functional regulators of CMV promoter‐driven transient gene expression in CHO cells
Authors: Brown Adam J. , Sweeney Bernie , Mainwaring David O. , James David C. 
Published: January 2015

AbstractTransient gene expression (TGE) in CHO cells is utilized to produce material for use in early stage drug development. These systems typically utilize the cytomegalovirus (CMV) promoter to drive recombinant gene transcription. In this study, we have mechanistically dissected CMV‐mediated TGE in CHO cells in order to identify the key regulators of this process. An in silico analysis of the promoter composition of transcription factor regulatory elements (TFREs) and the CHO cell repertoire of transcription factors identified eight TFREs as likely effectors of CMV activity. We determined the regulatory function of these elements by preventing their cognate transcription factors from binding at the CMV promoter. This was achieved by both scrambling promoter binding site sequences and using decoy molecules to sequester intracellular transcription factors. We determined that the vast majority of CMV activity is mediated by just two discrete TFREs, showing that simultaneous inhibition of NF‐κB and CRE‐mediated transactivation reduced CMV‐driven transient secreted alkaline phosphatase (SEAP) production by over 75%. Further, we identified a mechanism by which CMV‐mediated TGE is negatively regulated in CHO cells, showing that inhibition of YY1‐mediated transrepression increased SEAP production 1.5‐fold. This work enables optimization and control of CMV‐mediated TGE in CHO cells, in order to improve transient protein production yields.
Prognostic impact of lymph node metastasis in distal cholangiocarcinoma
Authors:   Nagoya Surgical Oncology Group, Kiriyama M , Ebata T , Aoba T , Kaneoka Y , Arai T , Shimizu Y , Nagino M , Shimoyama Y , Fukami Y , Miyake H , Sakamoto E , Takara D , Shirai K , Ohira S , Tojima Y , Hashimoto M , Akutagawa A , Yamaguchi R , Morofuji N , Kawahara T , Asaba Y , Mizuno S , Kawai S , Yamamoto H , Ikuta K , Matsubara H , Watanabe T 
Published: January 2015

Abstract

Background
The aim of the study was to investigate the prognostic impact of lymph node metastasis in cholangiocarcinoma using three different classifications.

Methods
Patients who underwent pancreaticoduodenectomy for distal cholangiocarcinoma in 24 hospitals in Japan between 2001 and 2010 were included. Survival was calculated by means of the Kaplan–Meier method and differences between subgroups were assessed with the log rank test. The Cox proportional hazards model was used to identify independent predictors of survival. χ2 scores were calculated to determine the cut-off value of the number of involved nodes, lymph node ratio (LNR) and total lymph node count (TLNC) for discriminating survival.

Results
Some 370 patients were included. The median (range) TLNC was 19 (3–59). Nodal metastasis occurred in 157 patients (42·4 per cent); the median (range) number of involved nodes and LNR were 2 (1–19) and 0·11 (0·02–0·80) respectively. Four or more involved nodes was associated with a significantly shorter median survival (1·3 versus 2·2 years; P = 0·001), as was a LNR of at least 0·17 (1·4 versus 2·3 years; P = 0·002). Involvement of nodes along the common hepatic artery, present in 21 patients (13·4 per cent), was also associated with a shorter survival (median 1·3 versus 2·1 years; P = 0·046). Multivariable analysis among 157 node-positive patients identified the number of involved nodes as an independent prognostic factor (risk ratio 1·87; P = 0·002).

Conclusion
The number of involved nodes was a strong predictor of survival in patients with distal cholangiocarcinoma.
Design and development of a two‐dimensional system based on hydrophilic and reversed‐phase liquid chromatography with on‐line sample treatment for the simultaneous separation of excreted xenobiotics and endogenous metabolites in urine
Authors: García‐Gómez Diego , Rodríguez‐Gonzalo Encarnación , Carabias‐Martínez Rita 
Published: January 2015

AbstractIn the present work we describe a two‐dimensional liquid chromatographic system (2D‐LC) with detection by mass spectrometry (MS) for the simultaneous separation of endogenous metabolites of clinical interest and excreted xenobiotics deriving from exposure to toxic compounds. The 2D‐LC system involves two orthogonal chromatographic modes, hydrophilic interaction liquid chromatography (HILIC) to separate polar endogenous metabolites and reversed‐phase (RP) chromatography to separate excreted xenobiotics of low and intermediate polarity. Additionally, the present proposal has the novelty of incorporating an on‐line sample treatment based on the use of restricted access materials (RAMs), which permits the direct injection of urine samples into the system. The work is focused on the instrumental coupling, studying all possible options and attempting to circumvent the problems of solvent incompatibility between the RAM device and the two chromatographic columns, HILIC and RP. The instrumental configuration developed, RAM‐HILIC‐RPLC‐MS/MS, allows the simultaneous assessment of urinary metabolites of clinical interest and excreted compounds derived from exposure to toxic agents with minimal sample manipulation. Thus, it may be of interest in areas such as occupational and environmental toxicology in order to explore the possible relationship between the two types of compounds. Copyright © 2015 John Wiley & Sons, Ltd.
A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra‐high‐performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application
Authors: Banda Jagadeesh , Lakshmanan Ramalingam , Vvs Shiva Prasad , Gudla Srinibas Patro , Prudhivi Rosaiah 
Published: January 2015

AbstractA simple and high sensitive ultra‐high‐performance liquid chromatography tandem mass spectrometry method for the determination of fludrocortisone in human plasma was developed and validated as per guidelines. The analyte and internal standard (IS), fludrocortisone‐d5, were extracted from human plasma via liquid–liquid extraction using tert‐butyl methyl ether. The chromatographic separation was achieved on a Chromolith RP18e column using a mixture of acetonitrile and 2 mm ammonium formate (70:30, v/v) as the mobile phase at a flow rate of 0.7 mL/min. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and positive ion mode. The precursors to product ion transitions monitored for fludrocortisone and IS were m/z 381.2 → 343.2 and 386.2 → 348.4, respectively. The assay was validated with linear range of 40–3000 pg/mL. The intra‐ and inter‐day precisions (relative standard deviation) were within 0.49–7.13 and 0.83–5.87%, respectively. The proposed method was successfully applied to pharmacokinetic studies in humans. Copyright © 2015 John Wiley & Sons, Ltd.
Study of tamoxifen urinary metabolites in rat by ultra‐high‐performance liquid chromatography time‐of‐flight mass spectrometry
Authors: Domínguez‐Romero Juan C. , García‐Reyes Juan F. , Beneito‐Cambra Miriam , Martínez‐Romero Rubén , Martinez‐Lara Esther , Del Moral‐Leal María L. , Molina‐Díaz Antonio 
Published: January 2015

AbstractTamoxifen (TMX) is a nonsteroidal estrogen antagonist drug used for the treatment of breast cancer. It is also included in the list of banned substances of the World Anti Doping Agency (WADA) prohibited in and out of competition. In this work, the excretion of urinary metabolites of TMX after a single therapeutic dose administration in rats has been studied using ultra‐high‐performance liquid chromatography electrospray time‐of‐flight mass spectrometry (UHPLC‐TOFMS). A systematic strategy based on the search of typical biotransformations that a xenobiotic can undergo in living organisms, based on their corresponding molecular formula modification and accurate mass shifts, was applied for the identification of TMX metabolites. Prior to UHPLC‐TOFMS analyses, a solid‐phase extraction step with polymeric cartridges was applied to urine samples. Up to 38 TMX metabolites were detected. Additional collision induced dissociation (CID) MS/MS fragmentation was performed using UHPLC‐QTOFMS. Compared with recent previous studies in human urine and plasma, new metabolites have been reported for the first time in urine. Metabolites identified in rat urine include the oxygen addition, owing to different possibilities for the hydroxylation of the rings in different positions (m/z 388.2271), the incorporation of two oxygen atoms (m/z 404.2220) (including dihydroxylated derivatives or alternatives such as epoxidation plus hydroxylation or N‐oxidation and hydroxylation), epoxide formation or hydroxylation and dehydrogenation [m/z 386.2114 (+O –H2)], hydroxylation of the ring accompanied by N‐desmethylation (m/z 374.2115), combined hydroxylation and methoxylation (m/z 418.2377), desaturated TMX derivate (m/z 370.2165) and its N‐desmethylated derivate (m/z 356.2009), the two latter modifications not previously being reported in urine. These findings confirm the usefulness of the proposed approach based on UHPLC‐TOFMS. Copyright © 2015 John Wiley & Sons, Ltd.
Characteristics of pain in amyotrophic lateral sclerosis
Authors: Hanisch Frank , Skudlarek Anika , Berndt Janine , Kornhuber Malte E. 
Published: January 2015

AbstractBackgroundPain is an often underestimated and neglected symptom in amyotrophic lateral sclerosis (ALS).MethodsIn a cross‐sectional survey, 46 patients with ALS, 46 age‐ and gender matched population‐based controls, and 23 diseased controls with myotonic dystrophy type 2 (DM2) were screened for occurrence, type, distribution, and treatment of pain and cramps. Data were collected with the use of the short form brief pain inventory (BPI).ResultsPain was reported in 78% of ALS patients,79% of DM2 patients, and 54% of controls (P < 0.05). More ALS patients than controls reported moderate to severe pain (42% vs. 20%). Pain in ALS patients interfered significantly more with daily activities than in controls (median pain interference score: 3.0 vs. 1.2, P < 0.05), especially enjoyment of life (5.0 vs. 1.0) and mood (3.0 vs. 1.0). There was no correlation between the duration of the disease and the severity of pain. Movement‐induced cramps were reported in 63% of ALS patients, mostly in the distal extremities. There was no difference in the duration of ALS disease between patients reporting cramps and those who did not.DiscussionOur study showed that pain was a relatively frequent symptom which had an important impact on the quality of life. Pain that requires treatment can occur at every stage of ALS.
Depression, anxiety disorders, and metabolic syndrome in a population at risk for type 2 diabetes mellitus
Authors: Kahl Kai G. , Schweiger Ulrich , Correll Christoph , Müller Conrad , Busch Marie‐Luise , Bauer Michael , Schwarz Peter 
Published: January 2015

AbstractBackgroundDepressive symptoms have been associated with type 2 diabetes mellitus (T2DM), but less is known about anxiety disorders that can be comorbid or exist without depression.MethodsWe evaluated the prevalence of psychiatric disorders in subjects consecutively examined at an outpatient clinic for diabetes prevention who were at‐risk for T2DM, defined by FINDRISK scores, and compared metabolic syndrome (MetS) frequencies between subjects with and without psychiatric morbidity, entering also relevant variables for MetS into multivariate analyses. All subjects underwent an oral glucose tolerance test (OGTT). Psychiatric diagnosis was confirmed using a Structured Clinical Interview for DSM‐IV.ResultsOf 260 consecutively screened subjects, 150 (56.9 ± 8.1 years old, males = 56.7%, BMI = 27.2 ± 4.1 kg/m2) were at‐risk for T2DM and were included. MetS, present in 27% of males and 25% of females, was significantly associated with having a current anxiety disorder (P < 0.001) and lifetime major depression (P < 0.001). In logistic regression analysis, MetS was significantly associated with lifetime major depression, presence of any anxiety disorder, body weight, and physical activity.ConclusionsOur data in a high‐risk group for T2DM support the association between depressive disorders and MetS, pointing to a similar role of anxiety disorders. Screening for anxiety and depression is recommended in this group at risk for T2DM.
Inhibition of RANKL‐dependent cellular fusion in pre‐osteoclasts by amiloride and a NHE10‐specific monoclonal antibody
Authors: Mine Yuichi , Shuto Takahiro , Nikawa Hiroki , Kawai Toshihisa , Ohara Masaru , Kawahara Kazuko , Ohta Kouji , Kukita Toshio , Terada Yoshihiro , Makihira Seicho 
Published: January 2015

AbstractThe functions of Na+/H+ exchangers (NHEs) during osteoclastic differentiation were investigated using the NHE inhibitor amiloride and a monoclonal antibody (MAb). Compared with sRANKL‐stimulated control cells, amiloride decreased the number of large TRAP‐positive osteoclast cells (OCs) with ≥10 nuclei and increased the number of small TRAP‐positive OCs with ≤10 nuclei during sRANKL‐dependent osteoclastic differentiation of RAW264.7 cells. NHE10 mRNA expression and OC differentiation markers were increased by sRANKL stimulation in dose‐ and time‐dependent manners. NHEs 1–9 mRNA expression was not increased by sRANKL stimulation. Similar to amiloride, a rat anti‐mouse NHE10 MAb (clone 6B11) decreased the number of large TRAP‐positive OCs, but increased the number of small TRAP‐positive OCs. These findings suggested that inhibition of NHEs by amiloride or an anti‐NHE10 MAb prevented sRANKL‐promoted cellular fusion. The anti‐NHE10 MAb has the potential for use as an effective inhibitor of bone resorption for targeted bone disease therapy.