bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Highly Diastereo‐ and Enantioselective Michael Addition of 3‐Substituted Benzofuran‐2(3H)‐ones to 4‐Oxo‐enoates Catalyzed by Lanthanide(III) Complexes.
Authors: Wang Zhen , Yao Qian , Kang Tengfei , Feng Juhua , Liu Xiaohua , Lin Lili , Feng Xiaoming 
Published: September 2014

AbstractFor the first time optical benzofuran‐2(3H)‐ones (VIII) bearing thioatom‐substituted quaternary stereocenters could be constructed.
ChemInform Abstract: Solvent Free Selective Dehydrogenation of Indolic and Carbazolic Molecules with an Iridium Pincer Catalyst.
Authors: Brayton Daniel F. , Jensen Craig M. 
Published: September 2014

AbstractPerhydro compounds obtained by high‐pressure hydrogenation with palladium on carbon undergo selective dehydrogenation of the heterocyclic ring using an iridium pincer catalyst IRC.
ChemInform Abstract: Nano‐Sized Polydopamine‐Based Biomimetic Catalyst for the Efficient Synthesis of Cyclic Carbonates.
Authors: Yang Zifeng , Sun Jian , Liu Xiaomin , Su Qian , Liu Ying , Li Qian , Zhang Suojiang 
Published: September 2014

AbstractPolydopamine nanoparticles are prepared and tested as catalyst for the reaction of oxirans and CO2.
ChemInform Abstract: A Highly Active and Magnetically Recoverable Tris(triazolyl)—CuI Catalyst for Alkyne—Azide Cycloaddition Reactions.
Authors: Wang Dong , Etienne Laetitia , Echeverria Maria , Moya Sergio , Astruc Didier 
Published: September 2014

AbstractThe tris(triazole) (MRC) is found to be a highly efficient catalyst for the title reaction.
ChemInform Abstract: Synthesis of 2‐Aryl‐5‐nitropyridines by Three‐Component Ring Transformation of 3,5‐Dinitro‐2‐pyridone.
Authors: Le Thi Song , Asahara Haruyasu , Kobiro Kazuya , Sugimoto Ryuichi , Saigo Kazuhiko , Nishiwaki Nagatoshi 
Published: September 2014

AbstractThe amount of NH4OAc is crucial to prepare exclusively the pyridine derivatives in high yields.
ChemInform Abstract: Organocatalytic Cascade Reactions: Diversity‐Oriented Synthesis for the Construction of Hydroisoquinoline Scaffolds.
Authors: Gomez Clarisa Villegas , Cruz David Cruz , Mose Rasmus , Joergensen Karl Anker 
Published: September 2014

AbstractAn organocatalytic cascade reaction mediated trienamine [4 + 2]‐cycloaddition/nucleophilic ring‐closing sequence is developed.
ChemInform Abstract: Diastereoselective Synthesis of Novel 5‐Substituted Morpholine‐3‐phosphonic Acids: Further Exploitation of N‐Acyliminium Intermediates.
Authors: Bonilla‐Landa Israel , Viveros‐Ceballos Jose Luis , Ordonez Mario 
Published: September 2014

AbstractDiastereoselective nucleophilic addition of trimethyl phosphite to an N‐acyliminium intermediate derived from substrate (I) gives cyclic α‐aminophosphonates.
ChemInform Abstract: Natural Tetraponerines: A General Synthesis and Antiproliferative Activity.
Authors: Bosque Irene , Gonzalez‐Gomez Jose C. , Loza Maria Isabel , Brea Jose 
Published: September 2014

AbstractA stereocontrolled general methodology to synthesize the eight natural tetraponerines (I) to (IV) is described and the anticancer activity of tetraponerines bearing a pentyl moiety against four different carcinoma human cell lines is examinated.
ChemInform Abstract: Identification of Thuridillin‐Related Aldehydes from Mediterranean Sacoglossan Mollusk Thuridilla hopei.
Authors: Carbone Marianna , Ciavatta M. Letizia , De Rinaldis Gianluca , Castelluccio Francesco , Mollo Ernesto , Gavagnin Margherita 
Published: September 2014

AbstractNorthuridillonal (I), dihydronorthuridillonal (IIa) and deacetyldehydronorthuridillonal (IIb) are isolated and their structures are evaluated.
ChemInform Abstract: Biologically Driven Synthesis of Pyrazolo[3,4‐d]pyrimidines as Protein Kinase Inhibitors: An Old Scaffold as a New Tool for Medicinal Chemistry and Chemical Biology Studies
Authors: Schenone Silvia , Radi Marco , Musumeci Francesca , Brullo Chiara , Botta Maurizio 
Published: September 2014

AbstractReview: 251 refs.
ChemInform Abstract: Microwave‐Assisted Synthesis of Benzo‐Fused Seven‐Membered Azaheterocycles
Authors: Sakhuja Rajeev , Bajaj Kiran , Abdul Shakoor S. M. , Kumar Anil 
Published: September 2014

AbstractReview: such as benzodiazepines, benzothiazepines and benzoxazepines; 102 refs.
ChemInform Abstract: Synthesis of 2,3,3,3‐Tetrafluoropropene (HFO‐1234yf) on Chrome‐Magnesium Fluoride Catalyst
Authors: Jukov A. A. , Barabanov V. G. , Ismagilov N. U. , Trukshin Y. G. , Shelopin G. G. 
Published: September 2014

AbstractReview: 8 refs.
Predictors and Outcome of Sustained Improvement in Left Ventricular Function in Dilated Cardiomyopathy
Authors: Blechman Ido , Arad Michael , Nussbaum Tamar , Goldenberg Ilan , Freimark Dov 
Published: September 2014

AbstractBackgroundImprovement in the left ventricular ejection fraction (LVEF) may occur in patients with dilated cardiomyopathy (DCM).HypothesisThere are different implications of persistent versus transient improvement in LVEF among DCM patients receiving contemporary therapy.MethodsWe studied 188 patients with nonischemic DCM. Persistent improvement in LVEF (PIEF) was defined as LVEF increase by at least 10% compared to baseline, and found in 2 separate echo‐Doppler exams performed at least 12 months apart. Increased LVEF in echo 2, which was not sustained in echo 3, was defined as transient improvement in LVEF (TIEF).ResultsOver an average follow‐up of 6.8 years, PIEF occurred in 61 (33%) patients, predicting a better long‐term outcome (P < 0.001) in a combined end‐point comprising death, heart transplantation, or the need for a ventricular assist device. The TIEF group had an intermediate course and were closer to nonimprovers (P = 0.003 vs PIEF). Multivariate logistic regression identified the following independent predictors of PIEF: shorter disease duration, pregnancy‐associated disease, left ventricular hypertrophy, and baseline LVEF ≤25%. A score to predict PIEF assigned 1 point to each of the following: disease duration <3 years and no familial cardiomyopathy; pregnancy‐associated presentation; basal LVEF ≤25%; and left ventricular wall thickness ≥12. A score of ≥3 was present in 44% of the patients, reliably predicting PIEF in 91% (P = 0.01).ConclusionsPersistent improvement in LVEF is associated with improved long‐term prognosis. Baseline clinical parameters can be used to identify patients likely to demonstrate PIEF, thereby allowing tailored management in this population.
Evaluation of Ascending Aorta Wall in Rheumatoid Arthritis by Tissue and Strain Doppler Imaging During Anti–Tumor Necrosis Factor‐α Therapy
Authors: Vizzardi Enrico , Cavazzana Ilaria , Sciatti Edoardo , Bonadei Ivano , D'Aloia Antonio , Tincani Angela , Franceschini Franco , Metra Marco 
Published: September 2014

AbstractBackgroundPatients with rheumatoid arthritis (RA) are at increased risk of vascular events. Data on the effects of tumor necrosis factor‐α (TNF‐α) blocking agents on aortic vascular function are still debated.HypothesisTo evaluate the effects of anti–TNF‐α treatment on elastic properties of the ascending aorta (distensibility, stiffness, and tissue Doppler imaging [TDI] strain) in RA patients.MethodsWe prospectively followed 13 patients affected by RA without cardiovascular risk factors for 1 year during anti–TNF‐α treatment. Every subject received an echocardiographic examination before starting anti–TNF‐α drugs and after 1 year. Aortic elastic properties were calculated from the echocardiographically derived thoracic aortic diameters, and TDI strain was measured on the wall of the ascending aorta 3 cm above the aortic valve.ResultsWe found lower distensibility (12.9 ± 3.5 vs 21.5 ± 7.5 mm Hg−1; P <0.001) and a higher stiffness index (21.3 ± 3.6 vs 11.7 ± 1.4; P <0.001) in RA cases at baseline compared with values after 1 year of treatment. Peak systolic (S′) and diastolic (E′ and A′) waves of the aortic wall TDI were similar at baseline and at 1 year follow‐up (S′ wave: 5.6 ± 2.2 cm/s vs 6.5 ± 2.6 cm/s, E′ wave: −4.6 ± 2.9 vs −5.0 ± 1.2 cm/s, A′ wave: −5.6 ± 0.19 vs −5.9 ± 2.05 cm/s), whereas TDI strain of the aortic wall was improved after anti–TNF‐α treatment (−23.7 ± 1.4% vs −31.6 ± 2.8%, P < 0.001).ConclusionsAnti–TNF‐α treatment after 12 months significantly modifies the elastic properties of the aorta. This may reflect the favorable changes in its elastic tissue after anti–TNF‐α treatment in RA patients without cardiovascular risk factors. This suggests a potential cardiovascular risk benefit.
Effective population size does not predict codon usage bias in mammals
Authors: Kessler Michael D. , Dean Matthew D. 
Published: September 2014

AbstractSynonymous codons are not used at equal frequency throughout the genome, a phenomenon termed codon usage bias (CUB). It is often assumed that interspecific variation in the intensity of CUB is related to species differences in effective population sizes (Ne), with selection on CUB operating less efficiently in species with small Ne. Here, we specifically ask whether variation in Ne predicts differences in CUB in mammals and report two main findings. First, across 41 mammalian genomes, CUB was not correlated with two indirect proxies of Ne (body mass and generation time), even though there was statistically significant evidence of selection shaping CUB across all species. Interestingly, autosomal genes showed higher codon usage bias compared to X‐linked genes, and high‐recombination genes showed higher codon usage bias compared to low recombination genes, suggesting intraspecific variation in Ne predicts variation in CUB. Second, across six mammalian species with genetic estimates of Ne (human, chimpanzee, rabbit, and three mouse species: Mus musculus, M. domesticus, and M. castaneus), Ne and CUB were weakly and inconsistently correlated. At least in mammals, interspecific divergence in Ne does not strongly predict variation in CUB. One hypothesis is that each species responds to a unique distribution of selection coefficients, confounding any straightforward link between Ne and CUB.
Cloud water interception and element deposition differ largely between Norway spruce stands along an elevation transect in Harz Mountains, Germany
Authors: Köhler Lars , Leuschner Christoph , Hauck Markus , Hertel Dietrich 
Published: September 2014

AbstractCloud deposition can contribute a significant amount of water and elements to montane forests and thus play an important role in the hydrological and biochemical cycles of these ecosystems. However, elevational pattern in cloud and throughfall input to forest ecosystems and the associated chemical element fluxes are poorly understood so far. We studied gross precipitation, throughfall and cloud water deposition, and the associated fluxes of elements (N, P, Ca, K, Mg and Na) in five mature stands of Norway spruce along an elevation transect from lowlands to the alpine treeline (420–1060 m) at Mt Brocken (Harz Mountains, Germany). We tested the hypotheses that water input increases with elevation despite a reduction in intercepting plant surfaces, leading to higher inputs of nitrogen and other elements to high‐elevation forests than in lower‐elevation stands. Gross precipitation (only snow‐free period) rose by 75% towards the treeline, but water input with throughfall increased by 350% because of a large increase in cloud water deposition (from 2 mm at 420 m to 160–200 mm at 1000 m in the study period). Element fluxes with gross precipitation were not uniformly related to elevation across all six elements. However, element fluxes via throughfall showed a positive correlation with elevation for all elements. Thus, the upper montane spruce forests received ~50–150% higher atmospheric inputs of base cations and inorganic N and ~200% higher P inputs than lower‐elevation forests. We conclude that elevation does have a large influence on the atmospheric water and element inputs in temperate mountain forests. Copyright © 2014 John Wiley & Sons, Ltd.
Chemodosimetric Detection of the Acetate Anion by Using the Template Reaction Method via a Fluorescence “Turn‐Off” Signal
Authors: Das Sudhanshu , Jana Sankar , Chakraborty Prateeti , Sanyal Ria , Maiti Dilip Kumar , Guchhait Nikhil , Zangrando Ennio , Das Debasis 
Published: September 2014

AbstractThe compartmental ligand 2,6‐bis[2‐(N‐ethyl)thiopheneiminomethyl]‐4‐chlorophenol (HL) undergoes Cu(ClO4)2 induced partial hydrolysis to yield a monoamine ligand 4‐chloro‐2‐formyl‐6‐[2‐(thiophen‐2‐yl)ethyliminomethyl]phenol (HL′). On further reaction with Cu(ClO4)2, HL′ produces a dinuclear complex, [Cu2(L′)2(ClO4)2] (2), which has been characterized in solution by UV/Vis, ATR, NMR, and ESI‐MS spectral techniques and in the solid state by X‐ray single‐crystal structure analysis. The in situ generated 2 is highly fluorescent. On reaction with sodium acetate it transforms to a fluorescence inactive tetranuclear species, [Cu4(L)2(OAc)4(O)] (3), and thereby acts as an excellent chemodosimeter for selective detection of the acetate anion via fluorescence “turn‐off” signalling. The direct reaction of HL and copper(II) acetate dihydrate yielded another fluorescence inactive tetranuclear species, [Cu4(L)2(OAc)4(O)] (1), which is a diastereoisomer of 3 as is evident from X‐ray single‐crystal structural analyses.
Syntheses and Properties of Multiferrocenylated Corannulenes
Authors: Topolinski Berit , Schmidt Bernd M. , Schwagerus Sergej , Kathan Michael , Lentz Dieter 
Published: September 2014

AbstractThe syntheses and properties of corannulenes bearing different numbers and types of ferrocenyl groups are described. Six different monoferrocenylated corannulenes were synthesized, and the crystal structure of 1‐corannulenyl‐1′‐(ferrocenyl)benzene was elucidated by single‐crystal X‐ray analysis. Further, diferrocenylated corannulenes bearing methyl or trifluoromethyl groups are reported. Buckybowls with four and five ferrocenyl substituents were synthesized from tetrabromocorannulene and the symmetrical pentachlorocorannulene. The molecular structure and nutshell‐like crystal packing of a tetraferrocenylated corannulene was determined by single‐crystal X‐ray analysis. Additionally, all compounds presented herein were subjected to electrochemical and optical measurements in solution.
Prussian Blue Films Produced by Pentacyanidoferrate(II) and Their Application as Active Electrochemical Layers
Authors: Morandi Pires Bruno , Venturinelli Jannuzzi Sergio Augusto , Barboza Formiga André Luiz , Alves Bonacin Juliano 
Published: September 2014

AbstractIron complexes such as ferri/ferrocyanides are usually employed as electrochemical mediators in portable devices for the quick diagnosis of diseases. Stable complexes designed for the electrochemical active layer may render devices with better performance and lifetimes than conventional devices. In this work we have synthesized and characterized spectroscopically, electrochemically, and by DFT the complex Na4[Fe(CN)5(isn)] (isn = isonicotinate). This complex was used as a single‐source precursor of Prussian Blue (PB) in solution at pH 2.0 and 3.0, as confirmed by UV/Vis spectroscopy. Potentiostatic deposition of PB onto glassy carbon electrodes provided stable films at pH 3.0 and 5.0, with electrocatalytic activity for ascorbic acid oxidation with a linear response in the range 20–200 μM and an limit of detection of 12 μM. The anodic peak potential of the modified electrodes varied with solution pH with a minimum value of 0.350 V versus NHE at pH 5.0.
Molecular cloning and tissue mRNA levels of 15 genes involved in lipid metabolism in Synechogobius hasta
Authors: Chen Qi‐Liang , Luo Zhi , Huang Chao , Zheng Jia‐Lang , Pan Ya‐Xiong , Song Yu‐Feng , Hu Wei 
Published: September 2014

The regulation of lipid metabolism is complex, and is currently an extensive area of research. In this study, the partial sequences of 15 genes involved in lipid metabolism were cloned from the liver of Synechogobius hasta, including g6pd, 6pgd, me, icdh, fas, accα, accβ, lpl, atgl, hsla, hslb, cpt 1a, srebp‐1, pparα, and pparγ. Phylogenetic analysis further identified these genes, and confirmed the classification and evolutionary status of S. hasta. mRNA of all genes was detected in the liver, spleen, muscle, gill, brain, intestine, and heart, but at varying levels.Practical applications: Excessive fat accumulation and disordered lipid metabolism have become serious problems in the sustainable and healthy development of aquaculture. The present study facilitates studies on the regulation of lipid metabolism at the molecular level in fish. The tissue expression profiles of genes increase our understanding of their physiological roles.In this study, the partial sequences of 15 genes involved in lipid metabolism were cloned and characterized from Synechogobius hasta, including g6pd, 6pgd, me, icdh, fas, accα, accβ, lpl, atgl, hsla, hslb, cpt 1a, srebp‐1, pparα, and pparγ. Phylogenetic analysis further identified these genes, and confirmed the classification and evolutionary status of S. hasta. mRNA of all genes was detected in the liver, spleen, muscle, gill, brain, intestine, and heart, but at the varying levels.
The Boulton–Katritzky Reaction: A Kinetic Study of the Effect of 5‐Nitrogen Substituents on the Rearrangement of Some (Z)‐Phenylhydrazones of 3‐Benzoyl‐1,2,4‐oxadiazoles
Authors: Frenna Vincenzo , Palumbo Piccionello Antonio , Cosimelli Barbara , Ghelfi Franco , Spinelli Domenico 
Published: September 2014

AbstractThe kinetics of the ring‐into‐ring conversion of some new (Z)‐phenylhydrazones of 3‐benzoyl‐1,2,4‐oxadiazole containing different nitrogen‐substituents at C‐5 (3b–d; X = NHMe, NMe2, and NHCOMe) into the relevant triazoles 4b–d have been examined in a wide range of pS+ (0.1–11.9) in 1:1 (v/v) dioxane/water solution. The obtained results have been compared with previous data concerning the (Z)‐phenylhydrazone of 5‐amino‐3‐benzoyl‐1,2,4‐oxadiazole (3a; X = NH2). All of the studied (Z)‐phenylhydrazones rearrange through three different pathways (specific acid‐catalysed, uncatalysed and general base‐catalysed). The different effects of the substituents on the course of the rearrangement in the three pathways have been examined.
Cesium Carbonate Promoted Direct Arylation of Hydroxylamines and Oximes with Diaryliodonium Salts
Authors: Yang Yang , Wu Xunshen , Han Jianwei , Mao Song , Qian Xiaofei , Wang Limin 
Published: September 2014

AbstractA transition‐metal‐free approach for the arylation of hydroxylamines and oximes with diaryliodonium salts was developed. The reaction proceeded smoothly at room temperature in the presence of cesium carbonate. As a result, a wide range of N‐ and O‐arylated hydroxylamines were synthesized in good to excellent yields (45–98 %).
One‐Pot Multiple Lithiation Processes of Fused Heterocycles
Authors: Jasselin‐Hinschberger Adeline , Comoy Corinne , Fort Yves 
Published: September 2014

AbstractAn efficient one‐pot process that involves two or three successive regioselective lithiation/electrophilic trapping stages has been developed that affords several polysubstituted derivatives in good overall yields by starting from 2‐chlorofuro[3,2‐b]pyridine.
A review of terrestrial radar interferometry for measuring surface change in the geosciences
Authors: Caduff Rafael , Schlunegger Fritz , Kos Andrew , Wiesmann Andreas 
Published: September 2014

AbstractThis paper presents a review of the current state of the art in the use of terrestrial radar interferometry for the detection of surface changes related to mass movement. Different hardware‐types and acquisition concepts are described, which use either real or synthetic aperture for radar image formation. We present approaches for data processing procedures, paying special attention to the separation of high resolution displacement information from atmospheric phase variations. Recent case studies are used to illustrate applications in terrestrial radar interferometry for change detection. Applications range from detection and quantification of very slow moving (millimeters to centimeters per year) displacements in rock walls from repeat monitoring, to rapid processes resulting in fast displacements (~50 m/yr) acquired during single measurement campaigns with durations of only a few hours. Fast and episodic acting processes such as rockfall and snow avalanches can be assessed qualitatively in the spatial domain by mapping decorrelation caused by those processes. A concluding guide to best practice outlines the necessary preconditions that have to be fulfilled for successful application of the technique, as well as in areas characterized by rapid decorrelation. Empirical data from a Ku‐band sensor show the range of temporal decorrelation of different surfaces after more than two years for rock‐surfaces and after a few seconds to minutes in vegetated areas during windy conditions. The examples show that the displacement field can be measured for landslides in dense grassland, ice surfaces on flowing glaciers and snowpack creep. Copyright © 2014 John Wiley & Sons, Ltd.
Early osteoblast responses to orthopedic implants: Synergy of surface roughness and chemistry of bioactive ceramic coating
Authors: Aniket  , Reid Robert , Hall Benika , Marriott Ian , El‐Ghannam Ahmed 
Published: September 2014

AbstractPro‐osteogenic stimulation of bone cells by bioactive ceramic‐coated orthopedic implants is influenced by both surface roughness and material chemistry; however, their concomitant impact on osteoblast behavior is not well understood. The aim of this study is to investigate the effects of nano‐scale roughness and chemistry of bioactive silica‐calcium phosphate nanocomposite (SCPC50) coated Ti‐6Al‐4V on modulating early bone cell responses. Cell attachment was higher on SCPC50‐coated substrates compared to the uncoated controls; however, cells on the uncoated substrate exhibited greater spreading and superior quality of F‐actin filaments than cells on the SCPC50‐coated substrates. The poor F‐actin filament organization on SCPC50‐coated substrates is thought to be due to the enhanced calcium uptake by the ceramic surface. Dissolution analyses showed that an increase in surface roughness was accompanied by increased calcium uptake, and increased phosphorous and silicon release, all of which appear to interfere with F‐actin assembly and osteoblast morphology. Moreover, cell attachment onto the SCPC50‐coated substrates correlated with the known adsorption of fibronectin, and was independent of surface roughness. High‐throughput genome sequencing showed enhanced expression of extracellular matrix and cell differentiation related genes. These results demonstrate a synergistic relationship between bioactive ceramic coating roughness and material chemistry resulting in a phenotype that leads to early osteoblast differentiation. © 2014 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 1961–1973, 2015.