bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between CD4+ T-cell count, atypical squamous cells and Schiller’s test in women with HIV/AIDS
Authors: Silva de Brito Daniele , Da Cunha Gilmara , Gir Elucir , Freitas Julyana , Galvao Marli 
Published: June 2024

Objective: Infection with HIV increased risk for the development of cancer, such as Kaposi’s sarcoma and invasive cancer of the cervix. Given the importance of health promotion in women, the purpose of this study was to perform cytological screening (Pap smear) and identify any association between CD4+ T-cell, atypical squamous cells and the Schiller’s Test in women with HIV/AIDS in Brazil.
Design: Descriptive and cross-sectional study.
Setting: Gynaecology outpatient clinic in Fortaleza, Ceará, Brazil.
Subjects: A total of 76 women with HIV/AIDS were examined and included in the study.
Main outcome measures: For data collection a questionnaire to gather sociodemographic, clinical, epidemiological and gynaecological data and the association between CD4+ T-cell count, atypical squamous cells and Schiller’s test in women with HIV/AIDS were performed.
Results: Seventy-six women were evaluated, among which 43.5% had a positive Schiller’s test and 94.8% manifested some type of inflammatory process. There was statistical significance between atypical squamous cells and the number of partners (P=0.021), age of first sexual intercourse (P=0.003) and positive Schiller’s test (P=0.008). Of the patients with atypical squamous cells, eight had a low-grade, intraepithelial lesion, comprising the cytopathic effect of HPV and cervical intraepithelial neoplasia grade I (CIN I); three had intraepithelial lesion high-grade (CIN comprising II and III). There was a relationship between CD4+ T-cell counts and atypical squamous cells (P=0.028) and a positive Schiller’s test (P=0.030).
Conclusion: Increased vulnerability occurred to cervix changes with a reduction in the CD4+ T-cell counts.
Potential drug–drug interactions in children with acute lymphoblastic leukaemia: a cohort study
Authors: Carvalho Soccal Daiana , Mombaque dos Santos Wendel , Marli Matiko Anraku de Campos Marli 
Published: June 2024

Objective: To evaluate the potential drug interactions in patients with acute lymphoblastic leukaemia in the remission induction period of treatment.
Design: A prospective cohort study.
Setting: A tertiary referral centre.
Subjects: Twenty-two children undergoing treatment for acute lymphoblastic leukaemia. The median age was 4.5 years (minimum of 1 and maximum of 18 years) with male predominance (54.4%).
Main outcome measure: Presence of potential drug interactions in patients undergoing treatment for precursor cell lymphoblastic leukaemialymphoma. The potential drug interactions term refers to the ability of a drug to affect the pharmacologic intensityas well as the therapeutic effect of another and cause adverse reactions, as well as the possibility of clinical manifestations.
Results: All participants were exposed to at least one potential drug interaction. About 60% of interactions classified as more severe. Every new drug included in the treatment increased the chance of potential drug-drug interactions by 0.4 times.
Conclusion: These results demonstrated the patients under chemotherapeutic care for lymphoblastic leukaemia-lymphoma have high potential for drug interactions of greater severity.
Diseño geométrico de un concentrador solar parabólico lineal
Authors: Benítez Centeno Omar Christian , López García Erik , Vargas Vega Minerva Guadalupe , Moreno Carpintero Enrique de Jesús , Cundapí Arroyo Roger Alejando , Sánchez Flores Juan Carlos 
Published: June 2024

La tecnología que se desarrolle para aprovechar el recurso solar de irradiancia a nivel mundial tendrá una tendencia ascendente muy importante hacia el 2050, el presente trabajo propone el diseño gométrico de un concentrador (colector) solar parabólico para aprovechar los elementos constitutivos para su construcción basandose en materiales disponibles comercialmente (hojas de acero inoxidables acabadoespejo, ), después de un cálculo del perfil de la parabola que es función de punto focal, se realizó un análisis para determinar el flujo de calor sobre el tubo absorbedor con diferentes distancias focales, a su vez se evaluaron las geometrías de los reflectores conforme se varía la distancia focal para asegurar que la distancia focal a usarse en eadecuada, desde el punto de vista geométrico y óptico, una distancia focal de 0.8 podría estar en un valor intermedio entre mayor zona de concentración y menor valor del pico máximo de concentración. Sin embargo, un análisis térmico debe ser hecho para garantizar que el tubo absorbedor trabajará bajo condiciones seguras desde el punto de vista térmico.
Estudio de Pertinencia de las Habilidades de los Egresados de Sistemas Computacionales Administrativos para los Empleadores de la Ciudad de Xalapa
Authors: Galván Sarabia Anabel , Hernández García Rodrigo Aryan , Cortés Viveros Noé , Calzada Cadena Amairani , Martínez Santes Marisol 
Published: June 2024

La Universidad Veracruzana ofrece 85 programas educativos, de los cuales se clasifican en áreas Artes, Ciencias Biológicas y Agropecuarias, Ciencias de la Salud, Económico-Administrativa, Humanidades y Técnica, estas a su vez están ubicadas en las 5 regiones del estado de Veracruz, pero en esta ocasión se enfoca en la Licenciatura en Sistemas Computacionales Administrativos en la región Xalapa, y de acuerdo con las necesidades de las cuales se tienen actualmente en el mundo empresarial y tecnológico. La facultad de Contaduría y Administración, región Xalapa ha comenzado el proceso de evaluación para poder renovar el próximo plan de estudios de dicha licenciatura, lo cual ayudara a garantizar que las habilidades, aptitudes y conocimientos adquiridos por los egresados estén alineadas con las demandas actuales del sector empresarial. Este proceso se apoya en datos del INEGI y del análisis realizado por Rodríguez (2020), que indican un aumento en la búsqueda de profesionales especializados en el área de sistemas computacionales administrativos. El objetivo principal de realizar este análisis es para poder brindar una mejor calidad de educación y generar más oportunidades laborales para los egresados, ofreciendo información objetiva sobre las necesidades específicas de las empresas locales. Además de que se busca lograr identificar cuáles son las tendencias laborales, evaluar el desempeño actual de los egresados en el mercado laboral y así determinar las habilidades más solicitadas por los empleadores. Finalmente, se logra destacar la importancia del porque se debe de actualizar de manera constantemente el plan de estudios de la carrera en Sistemas Computacionales Administrativos, esto para lograr satisfacer los cambios constantes del mercado laboral. Esto implica integrar habilidades técnicas y administrativas, manteniendo al mismo tiempo la flexibilidad necesaria para ajustarse a las demandas cambiantes dentro del sector tecnológico, informático y administrativo.
Instructional Design, Industry Partnerships, and QR Codes Improve Nursing Competency Evaluation
Authors: Scott Anthony , Yefimova Maria , Brand Ashley 
Published: June 2024

Background:
New medical devices are frequently introduced at the point of care, and nursing competence in their management is critical for safe patient care. Industry vendors often provide on-the-job in-services for new devices within the constraints of clinical priorities, yet these in-services are not usually monitored or systematically coordinated with stakeholders.

Method:
This project employed quick response (QR) codes and best practices in instructional design in a partnership with vendors to develop and evaluate the impact of an in-service for a new medical device on nursing competence. An online survey measured usefulness, knowledge, and the change in self-perceived competence.

Discussion:

A total of 536 nurses participated, and 91.2% correctly answered five or six of six questions about device management. The proportion of nurses rating their competence as
no experience
decreased from 21.2% to 4.5%, and ratings for
can do independently/competent
increased from 37.6% to 60.2%.

Conclusion:

The use of QR codes offers novel solutions to evaluate how structured, on-the-job education can positively impact nursing practice around medical devices.

[
J Contin Educ Nurs
. 2024;55(9):425–432.]
The Effect of Catheter-Related Infection Control Education on Surgical Nurses' Knowledge Levels and Attitudes: A Randomized Controlled Trial
Authors: Akdemir Habibe Filiz , Gezginci Elif 
Published: June 2024

Background
Catheters are commonly used in health care. As nurses play an active role in the prevention of catheter-related infections, their knowledge and attitudes on this subject are important. The goal of this study was to determine the effect of an educational intervention about catheter-related infection control precautions on nurses' knowledge levels and attitudes.

Method

This study was a single-center randomized controlled trial. The intervention group (
n
= 35) received evidence-based face-to-face education. The control group (
n
= 35) received routine in-service training. The nurses' knowledge and attitudes were assessed before, immediately after, and 3 months after the education.

Results

After the training, the intervention group had statistically higher total scores than the control group on both scales immediately after the training (
p
< .001 and
p
= .008, respectively) and 3 months after the training (
p
= .001 and
p
< .001, respectively).

Conclusion

The evidence-based structured educational intervention about catheter-related infection prevention practices positively affected the knowledge and attitudes of surgical nurses.

[
J Contin Educ Nurs.
2024;55(10):479–486.]
A Practical Approach to Integrating a Telehealth Course and Health Informatics Skills Into a Curriculum for Advanced-Level Nursing Students
Authors: Hebert Sharisse , Tietze Mari , Gaines Chloe 
Published: June 2024

Background:

Telemedicine and health informatics are a common aspect of patient care delivery in the United States. Graduate-level nursing students must be knowledgeable of telehealth and health informatics prior to entering the workforce as an advanced practice nurse. Nursing educators must provide educational opportunities within the curriculum that focus on telehealth and health informatics concepts that align with competencies.
The Essentials: Core Competencies for Professional Nursing Education
includes a new Domain #8 called, “Informatics and Healthcare Technologies,” where five key subdomains of this competency are defined.

Method:

This article describes the college's approach to incorporating telehealth and health informatics into the graduate-level curriculum and the associated alignment to the
2022 Essentials
.

Results:
Faculty professional development and course revision strategies improved the infrastructure for teaching telehealth and health informatics.

Conclusion:

The new Domain, #8, Informatics and Healthcare Technologies, can be successfully infused into the DNP curriculum with student engagement.

[
J Nurs Educ
. 2024;63(X):XXX–XXX.]
N’enseigne pas chez nous qui veut ! Les motifs de l’engagement des enseignants en microlycée
Authors: Zaffran Joël 
Published: June 2024

Le microlycée est un dispositif expérimental de retour volontaire aux études des jeunes en situation de décrochage scolaire. Sa mission est de les mener jusqu’aux épreuves du baccalauréat. Pour cela, des enseignants sont disposés à accompagner ces jeunes, quitte à sortir de leur rôle professionnel. L’article s’intéresse à ces enseignants qui s’engagent dans un microlycée malgré les infléchissements statutaires pour tenir la relation avec les jeunes. Quels sont les motifs de leur engagement ? Pour répondre, l’article procède en trois temps. Dans un premier temps, il présente le dispositif. Dans un deuxième temps, il repère dans les entretiens avec les enseignants les raisons du désir de « faire l’école autrement » qui préexiste à l’entrée au microlycée. Dans un troisième temps, il s’attarde sur le fonctionnement du microlycée de manière à montrer que les relations entre les pairs sont une condition de l’engagement au même titre que les relations avec les jeunes. En conclusion, l’article montre que si le microlycée est indispensable aux jeunes, il est utile aussi aux enseignants.
Débattre des transitions pour reconcevoir les formations
Authors: Joly Nathalie , Berriet-Solliec Marielle 
Published: June 2024

Cet article fait le bilan d’actions menées entre 2022 et 2023 dans un établissement d’enseignement supérieur en vue de mobiliser enseignants et étudiants autour d’une réflexion d’ensemble sur les façons d’adapter les formations aux défis de l’anthropocène. Les deux auteures analysent leur portage d’initiatives à la lueur des concepts de la sociologie des mobilisations et des recherches sur la participation du public en démocratie. En s’appuyant plus spécialement sur les travaux consacrés à l’institutionnalisation de la participation, elles distinguent parmi les initiatives impulsées celles qui relèvent d’une « participation conventionnelle » (création d’un groupe de travail Transitions, large sondage auprès des élèves-ingénieurs) et celles liées à une « participation non conventionnelle » (tribune publiée dans un média national et soumise à signature), ce choix étant destiné à impliquer un nombre plus étendu d’acteurs et à élargir l’échelle du débat, du local au national. In fine, la faiblesse des ressources et la quasi-absence de réseaux de sociabilité préexistants entre les différents protagonistes conduisent à un échec de la mobilisation nationale, tandis qu’un processus de transformation des contenus et des situations d’enseignement s’enclenche à petits pas, en l’absence de modes de gouvernance clairement établis pour leur accompagnement.
Enseigner le territoire : un enjeu appréhendé à partir d’une analyse renouvelée de la transposition didactique
Authors: Del Corso Jean-Pierre , Asloum Nina , Gillet Guillaume 
Published: June 2024

Au cours des dernières années les rénovations de programmes se succèdent dans le système de la formation agricole. De nouveaux objets d’enseignement émergent dans les curricula sans être toujours adossées à des savoirs clairement identifiés. Cette situation a pour conséquence de plonger les enseignants dans des états d’incertitude plus ou moins profonds. Partant de ce constat, l’article réinterroge la portée du modèle de Transposition Didactique initialement pensé par Yves Chevallard et Marie-Alberte Johsua. Ayant montré les spécificités du processus de transposition didactique à l’œuvre dans l’enseignement agricole, il examine l’intérêt de recourir à des dispositifs innovants de co-production de ressources pédagogiques conçus à l’articulation entre recherche et formation. Il débouche alors sur un modèle de TD enrichi. L’introduction récente de la thématique du territoire dans le référentiel de formation du module S2 « Territoires et sociétés » du baccalauréat Sciences et technologies de l’agronomie et du vivant (STAV) sert de cas d’étude.
A Clinical Trial Registry - India audit of listed head-and-neck cancer trials and studies from 2008-2022: A retrospective study
Authors: Roy Soumya Kanti , Kumar Meghna , Goyal Prachi , Qayyumi Burhanuddin 
Published: June 2024

ABSTRACT

Background:
Clinical trials are vital for advancing cancer treatment, but gaps exist in establishing ethical practices and transparency, especially in the context of head-and-neck cancers (HNCs) in India.

Objectives:
The primary objective of the study was to conduct a critical audit of the Clinical Trials Registry – India (CTRI) from 2008 to 2022; to quantify the number of studies and trials related to HNCs. Our secondary objective was to evaluate the credibility, accountability, and ethical advancements attributed to these registrations within India’s clinical research landscape.

Materials and Methods:
This was a retrospective study conducted between October 2022 and August 2023 at Homi Bhabha Cancer Hospital and Research Center, a tertiary cancer center in India. A thorough examination of the CTRI and PubMed databases was performed, encompassing 356 HNC trials registered at CTRI. Parallelly, 926 peer-reviewed publications from the leading clinical trial centers were assessed for credibility and accountability.

Results:
Of the 356 trials, 211 (59.3%) were interventional; however, 225 (63.2%) lacked explicit primary endpoints. Tata Memorial Center, Mumbai, India registered the maximum share with 98 (27.5%) trials registered during the period. Among the leading trial centers, notable discrepancy between CTRI registration and subsequent publication was observed, ranging from 2.2-8% across Tata Memorial Center (Mumbai), All India Institute of Medical Sciences (New Delhi), and Kasturba Medical College (Manipal).

Conclusion:
This audit exposed substantial ethical and transparency gaps, with a marked concentration in a few institutions within the Indian HNC clinical trials’ landscape. The study calls for urgent reforms to improve multi-institutional collaboration and ethical standards for enhanced human trials.
An objective cross-sectional assessment of ChatGPT in hematology-oncology manuscript composition: Balancing promise with factual inaccuracies
Authors: Singh Suvir , Prasad Pooja , Joshi Kaveri , Singh Jagdeep , Garg Nitish , Jain Kunal 
Published: June 2024

ABSTRACTBackground:Artificial intelligence (AI)-based large language models (LLMs), such as Chat Generative Pre-training Transformer (ChatGPT), exhibit promise in aiding manuscript composition and literature search, encompassing various research tasks. However, their utilization remains unregulated.Objectives:The primary objective of this study was to objectively assess the ability of ChatGPT 3.5 (free version) to assist with various tasks associated with manuscript preparation and research based on pre-defined scoring criteria. Secondary objectives included an assessment of the factual accuracy of data and any false information returned by ChatGPT.Materials and Methods:This cross-sectional study was planned in the Departments of Clinical Hematology and Medical Oncology of Dayanand Medical College and Hospital, Ludhiana, Punjab, India, a tertiary care referral center. Between July 1, 2023, and July 30, 2023, seven prompts comprising queries related to manuscript design, specific data, or complex discussion in hematology/oncology subjects were used. The responses were scored based on detailed pre-defined criteria for accuracy and completeness, and scoring was independently performed by a panel of five reviewers with current expertise in the field of hematology/medical oncology. Negative marking was performed for factual inaccuracies. Cronbach’s alpha and interclass correlation coefficient were calculated to assess inter-observer agreement.Results:ChatGPT readily provided information on the structural components of the manuscript and research design, with the ability to customize responses immediately. However, the presence of factual inaccuracies, fictional citations, and false information presented confidently were notable drawbacks. Cronbach’s alpha was 0.995, and the intraclass correlation coefficient was 0.995, indicating good inter-observer agreement. The overall score was 34.2 out of 90, with a poor score on the veracity of data and references.Conclusion:The current iteration of ChatGPT rapidly provides plausible and professional-looking information on up-to-date topics but is hindered by significant factual inaccuracies. Future research focusing on improving response accuracy and addressing ethical considerations of content generated by LLMs will help us maximize their potential in scientific paper development.
Lazertinib: A narrative drug review
Authors: Shaji Alan , Sharma Aparna 
Published: June 2024

ABSTRACT
Epidermal growth factor receptor (EGFR) activating mutations are established drivers in non-small-cell lung cancer (NSCLC); 85% of these mutations are exon 19 deletion or exon 21 L858R point substitution. Lazertinib (YH-25448, JNJ-73841937, LECLAZA®) represents one of the latest oral third-generation EGFR-tyrosine kinase inhibitor (TKI) binding irreversibly to the Cys797 residue in the adenosine triphosphate (ATP)-binding site of the EGFR kinase domain, with high selectivity for EGFR mutations including T790M. To write this narrative review, we searched online portals of ScienceDirect, PubMed, and Google Scholar and various websites such as the United States Food and Drug Administration (US-FDA) and UpToDate, using the search terms “Lazertinib,” “YH-25448,” “JNJ-73841937,” and “NSCLC.” We shortlisted 30 articles published between January 2021 and December 2023, of which we included 10 articles. This review elaborates on the indications for use, side effects and safety profile, drug interactions, and pharmacokinetics and dynamics. Key evidence that investigated the use of lazertinib has also been discussed.
Correlation of prognosis of oral squamous cell carcinoma with CD44 expression: A retrospective immunohistochemical analysis
Authors: Nanda Kumar H , Vasanthi V , Gunasekaran Nandhini , Divya Bose , Annasamy Ramesh Kumar , Krishnan Rajkumar 
Published: June 2024

ABSTRACT

Background:
Cluster of differentiation (CD44) is a cancer stem cell marker responsible for angiogenesis, invasion, and migration in oral squamous cell carcinoma (OSCC).

Objectives:
The primary objective of the study was to analyze the difference in expression of CD44 among different grades of OSCC. The secondary objective was to correlate the prognosis with the expression.

Materials and Methods:
Based on histopathological diagnosis, we retrieved OSCC paraffin-embedded blocks from the archives of the Department of Oral Pathology, Sri Ramaswamy Memorial (SRM) Dental College, Chennai, India, reported from January 2012 to May 2022. We evaluated sections from 15 tissues of normal oral mucosa, 15 paraffin blocks of well-differentiated OSCC, 15 moderately differentiated OSCC, and 15 poorly differentiated OSCC for CD44 immunostaining. Immunohistochemical expression of CD44 was studied in these tissues and graded based on the intensity of staining. The difference in immune expression of CD44 between different grades was quantitatively analyzed using image analysis by Fiji image analysis software. Analysis of variance (ANOVA) was used to compare the mean difference in expression between different groups by using the Statistical Package for Social Sciences (SPSS) software version 16. Statistical significance was set at P < 0.05.

Results:
We identified that 10% (n = 6) of the normal mucosa showed strong expression of CD44, whereas 13.3% (n = 8) of well-differentiated OSCC, 10% (n = 6) of moderately differentiated OSCC, and 0% (n = 0) of poorly-differentiated OSCC were strongly positive for CD44 expression. The difference in comparison was statistically significant (P, 0.003). By quantitative analysis, the mean expression of CD44-positive cells in well-differentiated OSCC was 38258 ± 4762, moderately-differentiated OSCC was 27353 ± 1357, and poorly-differentiated OSCC was 10265 ± 1685. Upon comparison, the difference in mean was found to be significant (P, 0.002).

Conclusion:
The expression of CD44 was noted to decrease from well-differentiated to poorly-differentiated OSCC.