bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hydrogels with Antioxidant Microparticles Systems Based on Hyaluronic Acid for Regenerative Wound Healing
Authors: Nacu Isabella , Ghilan Alina , Rusu Alina G. , Bercea Maria , Nita Loredana E. , Vereştiuc Liliana , Chiriac Aurica P. 
Published: August 2024

AbstractThis research focuses on the synthesis of hydrogels exhibiting enhanced antioxidant properties derived from hyaluronic acid (HA) and poly(ethylene brassylate‐co‐squaric acid) (PEBSA), a copolymacrolactone that have the ability to be used in drug delivery applications. Quercetin (Q), a bioflavonoid with strong antioxidant properties, is employed as a bioactive compound. The biomolecule is encapsulated in the polymeric network using different entrapment techniques, including the initial formation of a complex between PEBSA and Q, which is demonstrated through the dynamic light scattering technique. Fourier transform infrared spectroscopy (FT‐IR) and rheological studies confirm the formation of the hydrogels, revealing the occurrence of physical interactions between the synthetic polymer and the polysaccharide. Moreover, the hydrogels demonstrate biocompatible properties after direct contact with the HDFa cell line and antioxidant properties, as revealed by DPPH tests.
Green Electrospinning of Highly Concentrated Polyurethane Suspensions in Water: From the Rheology to the Fiber Morphology
Authors: Gross Bryan , Schlatter Guy , Hébraud Pascal , Mouillard Flavien , Chehma Lotfi , Hébraud Anne , Lobry Emeline 
Published: August 2024

AbstractSuspension electrospinning allows the environmental‐friendly fabrication of nano‐micro‐fibrous membranes since it is based on the processing of an aqueous particle suspension in which a hydrosoluble template polymer is added to insure the formation of a continuous fiber. Here, the case of polyurethane (PU) aqueous suspensions formulated with poly(ethylene oxide) (PEO) as the template polymer is studied. The effect of several parameters (particle size, PU/PEO ratio, PEO molar mass, and PEO concentration in the continuous phase) on particle‐particle and particle‐template polymer interactions that influence the rheological properties of the formulation and finally the electrospinning and the fiber morphology, is studied. The goal is to process a formulation with the highest particle content as possible. Thanks to a deep rheological investigation and the study of interactions and suspension morphology by zeta potential and diffusing wave spectroscopy, it is shown that regular fibers are efficiently produced when small particles are electrospun under favorable particle‐template polymer interactions and without screening the electrostatic repulsion between particles. Finally, a fibrous membrane is obtained from a formulation with a PU/PEO weight ratio equal to 50 under very stable and efficient production conditions.
A Minimalist Method for Fully Oxygen‐Tolerant RAFT Polymerization through Sulfur‐Centered Trithiocarbonate Radical Initiation
Authors: Wang Fei , Guo Yang , Huang Fubang , Han Shuang , Zhang Weidong 
Published: August 2024

AbstractIn recent years, the fully oxygen‐tolerant reversible deactivation radical polymerization (RDRP) has become a highly researched area. In this contribution, a new and minimalist method is successfully employed to accomplish fully oxygen‐tolerant reversible addition‐fragmentation chain transfer (RAFT) polymerization using bis(trithiocarbonate) disulfides (BisTTC) as an iniferter agent, where the released sulfur‐centered trithiocarbonate (TTC) radical can initiate monomer. Furthermore, polymerization kinetics revealed the typical “living” features of this polymerization system. More importantly, by high‐throughput screening, it is found that dodecyl‐substituted TTC is responsible for the fully oxygen‐tolerant RAFT polymerization though trithiocarbonate radical initiation and R radical deoxygenation. It is believed that trithiocarbonate radical initiation strategy provides a powerful and minimalist tool for fully oxygen‐tolerant RDRPs.
Academic publication uncertainty and research behavior
Authors: Goel Rajeev K. , Faria João Ricardo 
Published: August 2024

AbstractThere are many uncertainties in the production/dissemination of academic research. This paper incorporates publication uncertainty in a game model between researchers and journal editors, and examines its effects on the quantity and quality of research and on citations. Authors seek to maximize satisfaction from their publishing efforts, while journal editors try to enhance reputations of their journals. Publication probability depends on the number of academic journals. Results show that the impacts of a change in the number of journals (capturing publication uncertanty) on citations and quality are symmetric. Citations and research quality can go up, while total publications (research quantity) can increase, decrease, or stay unchanged.
Deciphering adiabatic rotating frame relaxometry in biological tissues
Authors: Pang Yuxi 
Published: August 2024

AbstractPurposeThis work aims to unravel the intricacies of adiabatic rotating frame relaxometry in biological tissues.Theory and MethodsThe classical formalisms of dipolar relaxation and were systematically analyzed for water molecules reorienting on “fast” and “slow” timescales. These two timescales are, respectively, responsible for the absence and presence of dispersion. A time‐averaged or over an adiabatic pulse duration was recast into a sum of and , but with different weightings. These weightings depend on the specific modulations of adiabatic pulse waveforms. In this context, stretched hyperbolic secant () pulses were characterized. Previously published , continuous‐wave (CW) , and measures from 12 agarose phantoms were used to validate the theoretical predictions. A similar validation was also performed on previously published (=1, 4, 8) and from bovine cartilage specimens.ResultsLongitudinal relaxation weighting decreases for pulses as increases. Predicted CW values from agarose phantoms align well with the measured CW values, as indicated by a linear regression function: . The predicted adiabatic and from cartilage specimens are consistent with those previously measured, as quantified by: .ConclusionThis work has theoretically and experimentally demonstrated that adiabatic and can be recast into a sum of and , with varying weightings. Therefore, any suggestions that adiabatic rotating frame relaxometry in biological tissues could provide more information than the standard and warrant closer scrutiny.
Robust dynamic output feedback predictive fault‐tolerant control for discrete uncertain systems
Authors: Wang Shiqi , Li Hui , Li Hua , Shi Huiyuan , Sun Qiubai , Li Ping 
Published: August 2024

AbstractA robust predictive fault‐tolerance control method integrating dynamic output feedback is proposed for discrete industrial processes with unmeasurable states, actuator faults, uncertainties, and external disturbances. First, a new iterative error model is developed, which extends the output tracking error to increase the freedom of controller regulation and ensure the tracking performance of the system. Second, a robust dynamic output feedback predictive fault‐tolerant controller is designed based on the preceding model. According to the Lyapunov stability theory, the robust stability criterion of the system is performed in the case of actuator faults, and the stability conditions of the system in the form of linear matrix inequality are given. The real‐time optimal control law gains are obtained by solving the stability conditions online. This method can effectively suppress the effects of actuator faults, uncertainties and external disturbances on the system with unmeasurable states, which can guarantee the tracking performance and stability of the system. The effectiveness of the proposed method is finally verified by using an injection molding process as an example.
Association Between Modified Frailty Index and Postoperative Outcomes of Cricopharyngeal Myotomy
Authors: Haleem Afash , Herz David , Kumar Keshav D. , Chinta Sree R. , Sibala Dhiraj R. , Hegazin Michael , Eloy Jean Anderson 
Published: August 2024

AbstractObjectiveThe modified 5‐item frailty index (mFI‐5) is a comorbidity‐based risk stratification tool previously validated in patients undergoing several surgical procedures. This study investigates the association between mFI‐5 score and cricopharyngeal myotomy (CM) complications.Study DesignRetrospective database review.SettingUS hospitals.MethodsThe National Surgical Quality Improvement Program database was queried for patients who underwent CM between 2005 and 2018. mFI‐5 score was determined by assigning 1 point for comorbidities including: diabetes mellitus, hypertension, congestive heart failure, chronic obstructive pulmonary disease, and dependent health status. Univariate and multivariable analyses were conducted to determine associations between mFI‐5 score and postoperative complications.ResultsA total of 1075 patients undergoing CMs were queried and stratified into the following groups: mFI = 0 (n = 412 [38.3%]), mFI = 1 (n = 452 [42.0%]), and mFI ≥ 2 (n = 211 [19.6%]). Univariate analysis showed association between higher mFI‐5 scores with older age, higher American Society of Anesthesiologists Classification class, obesity, smoking, dyspnea, and systemic sepsis. Higher mFI‐5 was associated with a greater proportion of cumulative surgical complications, cumulative medical complications, pneumonia, myocardial infarction, cumulative morbidity, readmissions, unplanned readmissions, and reoperations. Multivariable analyses found associations between greater mFI‐5 score and cumulative morbidity (odds ratio [OR] = 1.95, confidence interval [CI]: 1.29‐2.96, P = .002), any surgical complication (OR = 1.80, CI: 1.15‐2.79, P = .010), readmission (OR = 1.81, CI: 1.01‐3.26, P = .047), and reoperations (OR = 1.96, CI: 1.04‐3.68, P = .037).ConclusionEvaluating mFI‐5 can help assess the risk of postoperative complications for patients undergoing CM.Level of EvidenceLevel 4.
SARS‐CoV‐2 PLpro Inhibition: Evaluating in Silico Repurposed Fidaxomicin's Antiviral Activity Through In Vitro Assessment
Authors: Protić Sara , Crnoglavac Popović Milica , Kaličanin Nevena , Prodanović Olivera , Senćanski Milan , Milićević Jelena , Stevanović Kristina , Perović Vladimir , Paessler Slobodan , Prodanović Radivoje , Glišić Sanja 
Published: August 2024

AbstractThe emergence of drug‐resistant viruses and novel strains necessitates the rapid development of novel antiviral therapies. This need was particularly demanding during the COVID‐19 pandemic. While de novo drug development is a time‐consuming process, repurposing existing approved medications offers a more expedient approach. In our prior in silico screening of the DrugBank database, fidaxomicin emerged as a potential SARS‐CoV‐2 papain‐like protease inhibitor. This study extends those findings by investigating fidaxomicin‘s antiviral properties in vitro. Our results support further exploration of fidaxomicin as a therapeutic candidate against SARS‐CoV‐2, given its promising in vitro antiviral activity and favorable safety profile.
Enhancing PBAT nanocomposite films: The impact of AgVO3 nanorods on mechanical, hydrophobicity, and antibacterial properties
Authors: Venkatesan Raja , Alagumalai Krishnapandi , Jebapriya M. , Dhilipkumar Thulasidhas , Almutairi Tahani Mazyad , Kim Seong‐Cheol 
Published: August 2024

AbstractPoly(butylene adipate‐co‐terephthalate) (PBAT) is popular because of its low cost, biodegradability, good processing properties, flexibility, and mechanical features. In this study, we explore the potential of PBAT‐based bioplastics by adding AgVO3 nanorods with PBAT to reduce costs. We produced nanocomposite films of PBAT reinforced with 1, 3, and 5 wt% of AgVO3 nanorods using solvent casting. The inclusion of AgVO3 in the structure of PBAT was investigated through Fourier transform infrared spectroscopy, x‐ray diffraction, and scanning electron microscopy. The nanocomposite films demonstrate excellent properties, surpassing those of single‐component blends, enhancing mechanical properties, and improving the barrier properties of nanocomposite films. The water vapor transmission rate of AgVO3 reinforced (5 wt%) nanocomposite films improved by 42.45% compared to pure PBAT films. The tensile strength of the PBA‐3 film was 37.19 MPa, exhibiting higher strength than the films produced from clean PBAT (19.73 MPa). The AgVO3‐reinforced films demonstrated increased resistance to moisture and water, as indicated by their higher water contact angle values (88.04°). Food‐borne bacteria like Staphylococcus aureus and Escherichia coli have been stable to the antibacterial activity of the nanocomposites on the addition of AgVO3.The potential applications of these nanocomposite films in food packaging are promising, offering a sustainable and effective solution to food preservation.Highlights
The AgVO3‐filled poly(butylene adipate‐co‐terephthalate) (PBAT) nanocomposite films exhibit superior mechanical, barrier, and resistance to moisture and water compared to neat PBAT films.
The water vapor transmission rate of the film is significantly enhanced, with a 42.45% enhancement in films reinforced with 5 wt% AgVO3.
AgVO3‐filled PBAT nanocomposites demonstrate effective antibacterial activity against Escherichia coli and Staphylococcus aureus.
One‐way valves in breathing tubing reduce dead space during spontaneous breathing in anesthetized piglets
Authors: Li Pan , Wang Weiping , Gao Wen , Tan Yanling , Hu Yu , Jiang Li 
Published: August 2024

AbstractThe circle breathing system was unsafe for spontaneous breathing because of hypercapnia during anesthesia. Few studies have examined the minimizing dead space in breathing tubing. This study investigated one‐way valves in the breathing tubing during spontaneous breathing in piglets. Six female piglets aged 68–71 days spontaneously breathed sevoflurane for 4 h randomly via traditional or anti‐rebreathing tubing. Arterial carbon dioxide tension (PaCO2) and respiratory characteristics were used to assess spontaneous breathing efficiency. mRNA‐based methods, immunohistochemistry, and histology were used to assess the lungs. After induction, all piglets had mild hypercapnia. Those who breathed via traditional tubing experienced severe hypercapnia and required assisted ventilation (mean [95% confidence interval for mean]: 3 [0.5; 5.5] times) over 4 h. Piglets who breathed via anti‐rebreathing tubing were able to normalize without assisted ventilation in less than 3 h and maintained. PaCO2 was higher in the traditional group than the anti‐rebreathing group at 3 and 4 hours (46.3 [42.1; 50.5] vs. 38.3 [34.1; 42.5] mmHg, p = 0.020; 46.3 [42.6; 50.0] vs. 40.7 [37.0; 44.4] mmHg, p = 0.040). However, one‐way valves increased resistance to breathing. For the lungs, mRNA‐based methods indicated higher expressions of cyclin‐dependent kinase, cell division cycle 20, and cyclin B2 in the traditional group; immunohistochemistry identified higher expression of phosphorylated histone 2AX in the traditional group; histology showed similar damage between the groups. These findings suggest that one‐way valves inside breathing tubing reduced dead space during spontaneous breathing and enhanced inhalation anesthesia advantages in the circle breathing system.
Effect of silymarin on lipid profile and glycemic control in patients with type 2 diabetes mellitus
Authors: Ferdowsi Samira , Shidfar Farzad , Heidari Iraj , Kashi Maryam , Sohouli Mohammad Hassan , Sarrafi Zadeh Sara 
Published: August 2024

AbstractThis randomized clinical trial was conducted to evaluate the effects of silymarin supplementation on glycemic indices and serum lipid profile in type 2 diabetes mellitus (T2DM) patients. In this open‐label randomized clinical trial study, 48 patients with T2DM were eligible to participate for 12 weeks and were divided into two groups randomly: 24 subjects in the intervention (received three 140 mg silymarin capsules daily and diet plan) and 24 in control (received a diet plan). Fasting blood samples and anthropometric data were collected, and glycemic indices and lipid profiles were determined at baseline and at the end of the study. Out of 60 patients included in the clinical trial, 48 people completed the study. In comparing silymarin and control groups before and after the study, a significant reduction was observed in weight and body mass index. However, after adjustment, no significant difference was seen between the two groups. Furthermore, daily consumption of three capsules of 140 mg silymarin for 12 weeks did not show any significant difference on the level of fasting blood sugar (p = 0.789), HbA1c (p = 0.719), and lipid profile. The findings of the present study show that silymarin did not lead to changes in the level of glycemic index and lipid profile in patients with T2DM.
A novel treatment strategy targeting cellular pathways with natural products to alleviate sarcopenia
Authors: Lee Da Hee , Lee Hye Jin , Yang Gabsik , Kim Dae Yong , Kim Jong Uk , Yook Tae Han , Lee Jun Ho , Kim Hong Jun 
Published: August 2024

AbstractSarcopenia is a condition marked by a significant reduction in muscle mass and strength, primarily due to the aging process, which critically impacts muscle protein dynamics, metabolic functions, and overall physical functionality. This condition leads to increased body fat and reduced daily activity, contributing to severe health issues and a lower quality of life among the elderly. Recognized in the ICD‐10‐CM only in 2016, sarcopenia lacks definitive treatment options despite its growing prevalence and substantial social and economic implications. Given the aging global population, addressing sarcopenia has become increasingly relevant and necessary. The primary causes include aging, cachexia, diabetes, and nutritional deficiencies, leading to imbalances in protein synthesis and degradation, mitochondrial dysfunction, and hormonal changes. Exercise remains the most effective intervention, but it is often impractical for individuals with limited mobility, and pharmacological options such as anabolic steroids and myostatin inhibitors are not FDA‐approved and are still under investigation. This review is crucial as it examines the potential of natural products as a novel treatment strategy for sarcopenia, targeting multiple mechanisms involved in its pathogenesis. By exploring natural products' multi‐targeted effects, this study aims to provide innovative and practical solutions for sarcopenia management. Therefore, this review indicates significant improvements in muscle mass and function with the use of specific natural compounds, suggesting promising alternatives for those unable to engage in regular physical activity.
Shear behavior of stud and SFCBs‐reinforced PBL composite connectors in steel‐concrete structures
Authors: Wu Fangwen , Zhao Bitong , Liu Zhuo , Li Zirun , He Lanqing , Fan Zhou 
Published: August 2024

AbstractIn order to fully utilize the advantages of stud and perfobond leiste (PBL) connectors, a new composite shear connector was proposed in which the studs were welded to the H‐beam of the PBL shear connectors. In addition, to further improve the durability performance of the structure, steel‐fiber‐reinforced polymer composite bars (SFCBs) were used to replace steel rebars as penetrating rebars. In this study, the shear behaviors of SFCBs‐reinforced composite shear connectors were investigated by push‐out tests. The effects of the number of studs, the number of holes, and the type of penetrating rebars on the failure mode, load–slip curve, and shear behavior of the composite shear connectors were analyzed. The specimens' failure modes were mainly shearing the studs and crushing the concrete. Increasing the number of studs and holes has resulted in an increase of at least 7.47% in the shear resistance and 12.36% in the stiffness. SFCB had little effect on the shear resistance and reduced the stiffness but could improve ductility, with a maximum improvement of 11.49%. Additionally, a finite element model was established for parametric analysis. The results showed that the diameter of the SFCB and hole had a significant impact on the shear resistance. An equation for calculating the shear resistance based on the contributions of various components has been established that was applicable to composite shear connectors and has good accuracy and applicability.
One‐step non‐invasive diagnosis of metabolic dysfunction‐associated steatohepatitis and fibrosis in high‐risk population
Authors: Iruzubieta Paula , Mayo Rebeca , Mincholé Itziar , Martínez‐Arranz Ibon , Arias‐Loste María Teresa , Ibañez‐Samaniego Luis , Ampuero Javier , Abad Javier , Martín‐Mateos Rosa , Fernández‐Laso Ana Belén , Albillos Agustín , Bañares Rafael , Calleja José Luis , Romero‐Gómez Manuel , Aller Rocío , Crespo Javier 
Published: August 2024

AbstractBackground and AimType 2 Diabetes mellitus (T2DM), age, and obesity are risk factors for metabolic dysfunction‐associated steatotic liver disease (MASLD). We aimed to assess the performance of non‐invasive tests (NITs) for the diagnosis of metabolic dysfunction‐associated steatohepatitis (MASH) and fibrosis in high‐risk subjects.MethodsMulticentre cross‐sectional study that included 124 biopsy‐proven MASLD in more than 50 years‐old patients with overweight/obesity and T2DM. Vibration‐controlled transient elastography, Fibrosis‐4 index (FIB‐4), Non‐alcoholic fatty liver disease fibrosis score (NFS), OWLiver Panel (OWLiver DM2 + Metabolomics‐Advanced Steatohepatitis Fibrosis Score ‐MASEF) and FibroScan‐AST were performed. Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and area under the receiver operating characteristic curve (AUC) were calculated. NITs were assessed individually and in sequential/parallel combinations.Results35 (28.2%) patients had early MASH and 66 (53.2%) had MASH with significant fibrosis (at‐risk MASH). The OWLiver Panel correctly classified 86.1% as MASH, showing an accuracy, sensitivity, specificity, PPV, and NPV of 0.77, 0.86, 0.35, 0.85, and 0.36, respectively. Class III obesity, diabetes control, or gender did not impact on the performance of the OWLiver Panel (p > 0.1). NITs for at‐risk MASH showed an AUC > 0.70 except for NFS. MASEF showed the highest accuracy and NPV for at‐risk MASH (AUC 0.77 [0.68–0.85], NPV 72%) and advanced fibrosis (AUC 0.80 [0.71–0.88], NPV 92%). Combinations of NITs for the identification of at‐risk MASH did not provide any additional benefit over using MASEF alone.ConclusionOne‐step screening strategy with the OWLiver Panel has high accuracy to detect MASH and at‐risk MASH in high‐risk subjects for MASLD.