bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Keller‐Box Based Numerical Simulations and Prediction of Groundwater Flow via Darcy's Law
Authors: Usman  , Zhipeng Xia , Wang Jianhong 
Published: August 2024

AbstractComprehending and measuring heat transfer (HT) mechanisms in groundwater systems is crucial for tackling diverse issues and maximizing the use of subterranean resources while reducing ecological consequences. Groundwater flow is frequently simulated and predicted using mathematical models, such as Darcy's law, which governs the movement of fluids through porous media. Thus, a theoretical analysis of HT is therefore carried out for a time‐independent 3D power‐law (PL) nanofluid (NF) flow on the stretching rotating porous disc near the stagnation region, subject to convective boundary condition, using the MHD, heat source/sink, and thermal radiation effects. A numerical simulation via the Keller Box method is performed using PDEs as the mathematical model for the suggested problem. Investigations are conducted on how several classes of pertinent characteristics affect temperature, velocity, surface drag forces, and HT rate. It has been observed that the radial velocity of the disc increases with an escalation in the permeability of the porous media whereas the azimuthal velocity, however, tends to decrease. Additionally, the rate at which heat is transferred escalates as the radiation and heat source/sink parameter's strength increases whereas it decays along the Prandtl and Biot numbers. Lastly, the present study's results can be applied to understand the thermal impact on seepage of groundwater, geothermal energy extraction, containment systems for landfills and waste, design of subsurface infrastructure, aquifer thermal energy storage, and impact assessment against climate change.
All‐Solution‐Processed, All‐Organic Flexible Transistor and Circuit Based on Dry‐Transfer Polymer Films
Authors: Guo Shanlei , Sun Jing , Wang Xue , Tong Yanhong , Tang Qingxin , Liu Yichun 
Published: August 2024

AbstractOrganic thin‐film transistors (OTFTs), the key component of the future wearable electronics, have the outstanding advantages including cost‐effective, low‐temperature, and large‐area production. However, all‐organic TFTs with an all‐solution process and high‐precision electrode pattern remain an enormous challenge due to dissolution and incompatible fabricated processes between functional layers. Here, a universal, solution‐free transfer and lamination strategy is proposed, which is totally compatible with various commercial materials and fabricated technique in transistors. Excellent mechanical stability, good operation, high‐precision electrode patterns, and outstanding conformability are observed in the all‐organic TFTs. Moreover, as a proof‐of‐utility for the strategy, the all‐organic complementary inverters are fabricated based on all dry‐transfer processes with gain value of 11.2 and stable properties in 30 days in the air. This work provides a universal, solution‐free transfer and lamination strategy to fabricate high‐precision, all‐solution‐processed, all‐organic devices fully maximizing the great advantages of organic materials for the future multilayered functional, commercialized, and industrialized flexible electronics.
Health inequality in medieval Cambridge, 1200–1500 CE
Authors: Dittmar Jenna M. , Inskip Sarah A. , Rose Alice K. , Cessford Craig , Mitchell Piers D. , O'Connell Tamsin C. , Robb John E. 
Published: August 2024

AbstractHealth inequality is not only a major problem today; it left its mark upon past societies too. For much of the past, health inequality has been poorly studied, mostly because bioarchaeologists have concentrated upon single sites rather than a broader social landscape. This article compares 476 adults in multiple locations of medieval Cambridge (UK). Samples include ordinary townspeople (All Saints), people living in a charitable institution (the Hospital of St. John), and members of a religious order (the Augustinian Friary). These groups shared many conditions of life, such as a similar range of diseases, risk of injury, and vertebral disk degeneration. However, people living on charity had more indicators of poor childhood health and diet, lower adult stature, and a younger age at death, reflecting the health effects of poverty. In contrast, the Augustinian friars were members of a prosperous, well‐endowed religious house. Compared with other groups, they were taller (perhaps a result of a richer diet during their adolescent growth period); their adult carbon and nitrogen isotope values are higher, suggesting a diet higher in terrestrial and/or marine animal protein; and they had the highest prevalence of foot problems related to fashionable late medieval footwear. As this illustrates, health inequality will take particular forms depending upon the specificities of a social landscape; except in unusual circumstances where a site and its skeletal samples represent a real cross‐section of society, inequality is best investigated by comparison across sites.
Iridium(III) Photosensitizers Induce Simultaneous Pyroptosis and Ferroptosis for Multi‐Network Synergistic Tumor Immunotherapy
Authors: Zeng You‐Liang , Liu Liu‐Yi , Ma Tian‐Zhu , Liu Yu , Liu Bin , Liu Wenting , Shen Qing‐Hua , Wu Chao , Mao Zong‐Wan 
Published: August 2024

AbstractThe integration of pyroptosis and ferroptosis hybrid cell death induction to augment immune activation represents a promising avenue for anti‐tumor treatment, but there is a lack of research. Herein, we developed two iridium (III)‐triphenylamine photosensitizers, IrC and IrF, with the capacity to disrupt redox balance and induce photo‐driven cascade damage to DNA and Kelch‐like ECH‐associated protein 1 (KEAP1). The activation of the absent in melanoma 2 (AIM2)‐related cytoplasmic nucleic acid‐sensing pathway, triggered by damaged DNA, leads to the induction of gasdermin D (GSDMD)‐mediated pyroptosis. Simultaneously, iron homeostasis, regulated by the KEAP1/nuclear factor erythroid 2‐related factor 2 (NRF2)/heme oxygenase 1 (HO‐1) pathway, serves as a pivotal bridge, facilitating not only the induction of gasdermin E (GSDME)‐mediated non‐canonical pyroptosis, but also ferroptosis in synergy with glutathione peroxidase 4 (GPX4) depletion. The collaborative action of pyroptosis and ferroptosis generates a synergistic effect that elicits immunogenic cell death, stimulates a robust immune response and effectively inhibits tumor growth in vivo. Our work introduces the first metal‐based small molecule dual‐inducers of pyroptosis and ferroptosis for potent cancer immunotherapy, and highlights the significance of iron homeostasis as a vital hub connecting synergistic effects of pyroptosis and ferroptosis.
Solvent‐Engineering‐Assisted Ligand Exchange Strategy for High‐Efficiency AgBiS2 Quantum Dot Solar Cells
Authors: Zhong Qixuan , Zhao Bin , Ji Yongqiang , Li Qiuyang , Yang Xiaoyu , Chu Mingyu , Hu Yiqi , Li Lei , Li Shunde , Xu Hongyu , Yan Haoming , Huang Tianyu , Chen Peng , Chen Hao‐Hsin , Lu Zhangyuchang , Huangfu Yiming , Wu Jiang , Wang Dengke , Wang Ning , Cao Muhan , Gong Qihuang , Zhu Rui , Zhao Lichen 
Published: August 2024

AbstractAs the initial synthesized colloidal quantum dots (CQDs) are generally capped with insulating ligands, ligand exchange strategies are essential in the fabrication of CQD films for solar cells, which can regulate the surface chemical states of CQDs to make them more suitable for thin‐film optoelectronic devices. However, uncontrollable surface adsorption of water molecules during the ligand exchange process introduces new defect sites, thereby impairing the resultant device performance, which attracts more efforts devoted to it but remains a puzzle. Here, we develop a solvent‐engineering‐assisted ligand exchange strategy to revamp the surface adsorption, improve the exchange efficiency, and modulate the surface chemistry for the environmentally friendly lead‐free silver bismuth disulfide (AgBiS2) CQDs. The optimized AgBiS2 CQD solar cells deliver an outstanding champion power conversion efficiency (PCE) of up to 8.95 % and improved long‐term stability. Our strategy is less environment‐dependent and can produce solar cells with negligible performance variance for several batches across several months. Our work demonstrates the critical role of solvents for ligand exchange in the surface chemistry of CQDs and the realization of high‐performance photovoltaic devices in a highly reproducible manner.
Effects of BixOyIz Self‐Combination and Integration With Magnetic CoFe2O4 on the Enhanced Removal Efficiencies for Tetracycline Residues
Authors: Zhao Mei , Tan Cuiyan , Liu Mengchen , Wang Ye , Ren Haoran , Yu Xinyu , Zhang Zhihua , Wang Wenjun , Li Chengdong 
Published: August 2024

ABSTRACTThe BixOyIz and CoFe2O4 combination enhances photocatalytic degradation of tetracyclines (TCs). Three TC antibiotics including TC, oxytetracycline (OTC), and chlortetracycline (CTC) with high concentration (50 mg L−1) were utilized as target pollutant. Bi5O7I/Bi4O5I2, with its Z‐scheme, improves removal efficiency to 1.6 times that of Bi5O7I and 1.4 times that of Bi4O5I2. Ternary Bi5O7I/Bi4O5I2/CoFe2O4 (I/I/Co) composites further increase efficiency, with I/I/Co‐2 achieving 1.6 times that of I/I‐2. The improved performance is due to an optimized microstructure, which promotes light absorption and carrier transfer. CoFe2O4 nanoparticles on nanosheets create a double‐Z band structure, enhancing redox activity. Radical trapping experiments indicated the major active species (•O2−, OH−, and h+) in photocatalytic process of I/I/Co‐2. Based on their enhanced removal efficiencies for high‐concentration TCs, proper magnetic separation capacity, and recycling performance, the practical applications of I/I/Co composites to treat real TC wastewater might be implemented.
A comprehensive analysis of the tubarial glands
Authors: Ebrahim Alisha , Reich Caitlan , Wilde Kurt , Salim Aly Muhammad , Hyrcza Martin D. , Willetts Lian 
Published: August 2024

AbstractThe tubarial glands (TGs) are a collection of salivary glands (SGs) located within the nasopharynx, proximal to the eustachian tube. Currently, there is no quantitative characterization of the TGs. We investigated the histological architecture of the TGs and compared it with the major and minor SGs for categorization. Tubarial, parotid, submandibular, sublingual, buccal, labial, and lingual glands were excised from human donors (8 male and 3 female). Hematoxylin and eosin‐stained tissue sections were analyzed to measure the area of the largest lobule, number of ducts, number of mucinous acini, and mean mucinous acini area. Based on our observation, the TGs' histology resembles the minor SGs, while having some unique characteristics that distinguish them from both major and minor SGs. The area of the largest lobule in the TGs and minor SGs was smaller than the major SGs. TGs have a lower number of ducts than the major and minor SGs. TGs contain densely packed clusters of predominantly mucinous acini surrounded by loose connective tissue resembling minor SGs. This density may explain their previously observed high prostate‐specific membrane antigen uptake. In our cohort of donors, sex‐based differences were observed in the mean mucinous acini area between male and female TGs, submandibular and sublingual glands. Taken together, our findings suggest the histological characteristics of all SGs are better organized on a spectrum rather than discrete groups (major vs. minor) and provide information to open new avenues for research into the TGs' role in head and neck pathologies and sexual dimorphism of the SGs.
Wilyakali and archaeologists collaborating to map the journey of the Bronzewing Pigeon, Broken Hill, western New South Wales, Australia
Authors: Martin Sarah , Witter Dan , O'Donnell Dulcie , O'Donnell Raymond , Clark Sandra , O'Donnell Raymond , Bates Badger 
Published: August 2024

ABSTRACTThis paper describes a collaboration between Wilyakali Indigenous Custodians and a group of archaeologists. This collaboration has generated a shared and integrated understanding of the cultural landscape, Ancestral Creation Histories, and archaeology of the Broken Hill region of western New South Wales. The Broken Hill landscape is ancient beyond imagination, and complex geological processes/Creation Histories have resulted in distinctive landscape features and resources including quartz suitable for stone artefact manufacture. Wilyakali stone knappers employed specialised and varied technological processes to overcome the diverse and sometimes intractable nature of the quartz material, resulting in efficient use of this local stone resource. Wilyakali interpret the Country through their knowledge of the travelling sacred Bronzewing Pigeon and its creation of landscape features and resources such as quartz and water. Empirical archaeological data complement traditional knowledge, with the two ways of knowing coming together to reconstruct a nuanced interpretation of the cultural landscape. This shared narrative has had ongoing and inter‐generational benefits to the Wilyakali people, with knowledge communicated to younger generations by Elders, enabling them to interpret both the archaeology and Ancestral Creation Histories with confidence. This paper also highlights the inconsistent recognition of Indigenous ways of knowing and connection in Aboriginal cultural heritage assessments in the region.
360‐Degree partnerships that create win‐win‐win scenarios for dual credit students at Odessa College
Authors: Fuentes Jonathan , Hicks Janice 
Published: August 2024

AbstractSince fall 2019, Odessa College's dual credit program has grown by 67%. Texas’ initiatives, around college, career, and military readiness (CCMR), certainly provided an impetus for growth in dual credit, but this tremendous level of growth points to a number of structural changes Odessa College made to its dual credit program. The article focuses how the college created deeper, systemic partnerships between the dual credit program and the school districts.
Consensus recommendations for systemic therapies in the management of relapsed Ewing sarcoma: A report from the National Ewing Sarcoma Tumor Board
Authors: Gupta Ajay , Dietz Matthew S. , Riedel Richard F. , Dhir Aditi , Borinstein Scott C. , Isakoff Michael S. , Aye Jamie M. , Rainusso Nino , Armstrong Amy E. , DuBois Steven G. , Wagner Lars M. , Rosenblum Jeremy M. , Cohen‐Gogo Sarah , Albert Catherine M. , Zahler Stacey , Chugh Rashmi , Trucco Matteo 
Published: August 2024

AbstractEwing sarcoma (ES) is a malignant tumor of bone and soft tissue that most often occurs in children, adolescents, and young adults. Debate and controversy remain in the management of relapsed/refractory ES (RR‐ES). The authors leveraged the expertise assembled by the National Ewing Sarcoma Tumor Board, a multidisciplinary virtual tumor board that meets monthly to discuss challenging cases of ES. In this review, they focus on select topics that apply to the management of patients with RR‐ES. The specific topics covered include the initial approach of such patients and discussion of the goals of care, the role of molecular testing, chemotherapy regimens and novel agents to consider, the role of maintenance therapy, and the use of high‐dose chemotherapy with autologous stem cell rescue. The data referenced are often limited to subgroup analyses and/or compiled from multiple sources. Although not intended to replace the clinical judgement of treating physicians, these guidelines are intended to support clinicians and provide some clarity and recommendations for the management of patients with RR‐ES.Plain Language Summary

Ewing sarcoma (ES) is a bone and soft tissue cancer that most often occurs in teenagers and young adults.
This article uses the experience of the National Ewing Sarcoma Tumor Board, a multi‐institution, multidisciplinary virtual tumor board that meets monthly to discuss challenging cases of ES and to address questions related to the treatment of patients with relapsed ES.
Although not intended to replace the clinical judgement of treating physicians and limited by available data, these consensus recommendations will support clinicians who treat patients with this challenging malignancy, made even more difficult when it recurs.
Fetal cervical sarcoma: Comparison between virtual and real fetal bronchoscopy
Authors: Micheletti Talita , Castro Pedro Teixeira , Araujo Júnior Edward , Castellano Marco Aurélio , Andrade Cristiano Feijó , Werner Heron 
Published: August 2024

AbstractFetal cervical tumors are a life‐threatening condition if proper diagnosis and perinatal care are inadequate. The most common causes of fetal cervical masses are teratomas and lymphangiomas. Less common tumors may obstruct the fetal airway due to cervical compression. In this case report, a fetus with a cervical sarcoma was evaluated by ultrasound and MRI. The prenatal imaging characteristics of the tumor were described, virtual navigation of the fetal airway was performed and compared with fetal bronchoscopy to evaluate the consistency of the tumor. Neonatal outcome was also described.
Entrepreneurial culture and leadership: Evidence of the importance of intention
Authors: Fayez Akram Sami , AL‐Abrrow Hadi , Abdullah Hasan Oudah , Alnoor Alhamzah , Abbas Sammar 
Published: August 2024

AbstractThis research aims to investigate how entrepreneurial leadership and culture impact entrepreneurial behavior through the mediating role of entrepreneurial intention in Iraq's hotel industry. Information was gathered from 625 individuals employed in private restaurants and hotels, and a structural equation model, SEM, was utilized to analyze this data. Despite close focus on studying actual entrepreneurial behavior, the results of the current study emphasize the crucial role of entrepreneurial intention in the emergence of actual behavior. The entrepreneurial intention acts as a comprehensive mediator impacting entrepreneurial leadership and culture on entrepreneurial behavior. This underscores the pivotal role of individual intentions in translating organizational influences into tangible actions. The study emphasizes the significance of understanding and nurturing these intentions as drivers of entrepreneurial behavior. The implications extend to professionals in the industry, advocating for initiatives to foster an entrepreneurial mindset, cultivate supportive cultures, and empower employees to stimulate change. These insights offer a proactive framework for organizations to navigate dynamic challenges and capitalize on entrepreneurial opportunities in the sector.
Explainable machine‐learning‐based prediction of QCT/FEA‐calculated femoral strength under stance loading configuration using radiomics features
Authors: Liu Shuyu , Zhang Meng , Gong He , Jia Shaowei , Zhang Jinming , Jia Zhengbin 
Published: August 2024

AbstractFinite element analysis can provide precise femoral strength assessment. However, its modeling procedures were complex and time‐consuming. This study aimed to develop a model to evaluate femoral strength calculated by quantitative computed tomography‐based finite element analysis (QCT/FEA) under stance loading configuration, offering an effective, simple, and explainable method. One hundred participants with hip QCT images were selected from the Hong Kong part of the Osteoporotic fractures in men cohort. Radiomics features were extracted from QCT images. Filter method, Pearson correlation analysis, and least absolute shrinkage and selection operator method were employed for feature selection and dimension reduction. The remaining features were utilized as inputs, and femoral strengths were calculated as the ground truth through QCT/FEA. Support vector regression was applied to develop a femoral strength prediction model. The influence of various numbers of input features on prediction performance was compared, and the femoral strength prediction model was established. Finally, Shapley additive explanation, accumulated local effects, and partial dependency plot methods were used to explain the model. The results indicated that the model performed best when six radiomics features were selected. The coefficient of determination (R2), the root mean square error, the normalized root mean square error, and the mean squared error on the testing set were 0.820, 1016.299 N, 10.645%, and 750.827 N, respectively. Additionally, these features all positively contributed to femoral strength prediction. In conclusion, this study provided a noninvasive, effective, and explainable method of femoral strength assessment, and it may have clinical application potential.
DNA methylation of bone morphogenetic protein 7 in leukocytes as a possible biomarker for hand osteoarthritis: A pilot study
Authors: Kuroiwa Takashi , Tsuboi Yoshiki , Michikawa Takehiro , Tajima Kaori , Uraya Yuki , Maeda Atsushi , Shizu Kanae , Suzuki Katsuji , Suzuki Koji , Kawano Yusuke , Fujita Nobuyuki 
Published: August 2024

AbstractHand osteoarthritis (HOA), characterized by an earlier onset age and reduced susceptibility to mechanical stress compared with knee and hip osteoarthritis, is considered a suitable disease for identifying predictive biomarkers of osteoarthritis. In particular, DNA methylation variants, expected to contribute to HOA susceptibility, hold potential as osteoarthritis biomarkers. In this study, leukocyte DNA methylation patterns were analyzed in blood samples from patients with HOA, aiming to identify disease‐specific biomarkers for osteoarthritis. Using DNA methylation microarrays, we analyzed samples from three subjects with HOA and three age‐ and gender‐matched healthy individuals. For validation, pyrosequencing analysis was conducted using samples from 16 to 9 subjects with and without HOA, respectively. From 735,026 probes in the DNA methylation array, the Top 100 CpG sites associated with HOA, based on low adjusted P‐values, including those targeting bone morphogenetic protein 7 (BMP7), SBF2‐AS1, PLOD2, ICOS, and CSF1R were identified. Validation analysis revealed significantly higher methylation levels in the BMP7‐related site in the HOA group compared with the control group, even after adjusting for age, gender, and body mass index (p = 0.037). In contrast, no significant difference was observed in the other selected CpG sites between the HOA and control groups. This study highlights the significantly increased frequency of methylation at the specific BMP7 site in leukocytes of patients with HOA, suggesting its potential as a biomarker for HOA. Measurement of methylation levels at the CpG sites identified in this study offers a potential approach to prevent future osteoarthritis progression, providing valuable insights into disease management.