bluuebunny/crossref_metadata_2025_split huggingface dataset:
Fatigue Behaviour of Lead-Free Solder Interconnections in Life Prediction of Trilayer Structures Subjected to Thermal Cycling
Authors: Shirazi Alireza , Lu Hua , Varvani-Farahani Ahmad 
Published: September 2015

Trilayer structures such as flip chip plastic ball grid array (FC-PBGA) packages are bodies made of a large variety of dissimilar materials. Due to the coefficients of thermal expansion (CTE) mismatches between and temperature gradients within the layers, thermally induced interaction becomes a typical type of the loads for the joint layer made of lead-free solder joint interconnections. Thermal stresses and strains at the interfaces of solder joints and neighboring adhesive layers are the cause for solder joint fatigue failures, which account for the most common package failures. The current study puts forward a fatigue life prediction method for a trilayer structure using the critical plane-energy fatigue damage parameter in combination with the modified Coffin-Manson life model.
The proposed method of calculated fatigue damage parameter for the samples of study, along with their experimental life (Nf50%) under two different thermal conditions is presented. The values of life in (0–100°C) condition and (25–125°C) with the same temperature ramp rate and dwell conditions are found to differ by a factor of 1.3 where the structures tested under (0–100°C) condition show lower lives.
The present study further correlated the fatigue damage parameters with the Coffin-Manson type equation to calculate/predict the fatigue life of structures under (25–125°C) condition. The results of the Nf50 fatigue life prediction versus the experimental cycles show that the predicted lives of samples with SAC305 solder joints fall apart with a factor ranging from (1.24)∼(−1.45).
The advantage of the proposed method in comparison with the existing methods in life prediction of the trilayer structure with solder alloy is that there are no empirical parameters involved in energy-critical plane damage parameter in life prediction of the trilayer structure. Parameters within the proposed approach purely involves mechanical and fatigue properties of the midlayer alloy.
Research on a Novel High-Speed Pulsating Turning Technology
Authors: He Yuanfeng , Zhang Wenwu 
Published: September 2015

As one of the most important machining methods, common turning has been applied on vast machining fields. Parts in revolving shape can be easily machined using lathe machine. But severe cutting heat is often generated by the contact of tool and work-piece in the procedure of turning. High cutting heat not only affects tool life and processing quality but also leads to low cutting efficiency and high energy consumption.
As to the demands of processing work-piece in large scale like marine shaft, heavy lathe is utilized. Considering the inertia load and the stability of the whole machine, speed of spindle is limited and the cutting efficiency is limited thusly because cutting speed is determined by rotate speed of spindle with fixed tool.
A novel high-speed pulsating turning technology (HSPT) was proposed in this paper. The contact relation between tool and work-piece was modified to be pulsating instead of continuous in common methods. The advantages of HSPT include lower energy consumption, less cutting heat, higher cutting speed compared with common method. Features of energy consumption, contact duration of tools and work-piece, surface roughness, etc. was investigated through theoretical analysis and experiment study, which have verified the advanced performance of HSPT.
Effect of Toolpath on the Springback of 2024-T3 Aluminum During Single Point Incremental Forming
Authors: Reese Zachary C. , Ruszkiewicz Brandt J. , Nikhare Chetan P. , Roth John T. 
Published: September 2015

Incremental forming is a nontraditional forming method in which a spherical tool is used to asymmetrically deform sheet metal without the need for expensive allocated dies. Incremental forming employs a tool path similar to that used when CNC milling. Hence, when forming a part, the forming tool makes a series of passes circumferentially around the workpiece, gradually spirally stepping down in the z-axis on each sequential pass. This tool path deforms the sheet metal stock into the final, desired shape. These passes can start from the outer radius of the part and work in (Out to In, OI forming) or they can start from the center of the shape and work outward (In to Out, IO forming).
As with many sheet metal operations, springback is a big concern during the incremental forming process. During the deformation process, residual stresses are created within the workpiece causing the final formed shape to springback when it is unclamped, sometimes very significantly. The more complex the geometry of the final part and the more total deformation that occurs when forming the geometry, the greater the residual stresses that are generated within the part. The residual stresses that have built up in the piece cause more significant distortion to the part when it is released from the retaining fixturing. This paper examines how the step size (in the z direction), OI vs. IO forming, and final part geometry affect the total springback in a finished piece. For all of these tests 0.5 mm thick sheets of 2024-T3 aluminum were used to form both the truncated pyramid and truncated cone shape. From this investigation it was found that smaller step sizes result in greater springback, IO is significantly less effective in forming the part (due to workpiece tearing), and final part geometry plays an important role due to the creation of residual stresses that exist in corners.
Analytic reconstruction algorithms for triple‐source CT with horizontal data truncation
Authors: Chen Ming , Yu Hengyong 
Published: September 2015

Purpose:This paper explores a triple‐source imaging method with horizontal data truncation to enlarge the field of view (FOV) for big objects.Methods:The study is conducted by using theoretical analysis, mathematical deduction, and numerical simulations. The proposed algorithms are implemented in c + + and matlab. While the basic platform is constructed in matlab, the computationally intensive segments are coded in c + +, which are linked via a mex interface.Results:A triple‐source circular scanning configuration with horizontal data truncation is developed, where three pairs of x‐ray sources and detectors are unevenly distributed on the same circle to cover the whole imaging object. For this triple‐source configuration, a fan‐beam filtered backprojection‐type algorithm is derived for truncated full‐scan projections without data rebinning. The algorithm is also extended for horizontally truncated half‐scan projections and cone‐beam projections in a Feldkamp‐type framework. Using their method, the FOV is enlarged twofold to threefold to scan bigger objects with high speed and quality. The numerical simulation results confirm the correctness and effectiveness of the developed algorithms.Conclusions:The triple‐source scanning configuration with horizontal data truncation cannot only keep most of the advantages of a traditional multisource system but also cover a larger FOV for big imaging objects. In addition, because the filtering is shift‐invariant, the proposed algorithms are very fast and easily parallelized on graphic processing units.
Genome Sequence of Porphyromonas gingivalis Strain A7436
Authors: Chastain-Gross Ryan P. , Xie Gary , Bélanger Myriam , Kumar Dibyendu , Whitlock Joan A. , Liu Li , Farmerie William G. , Daligault Hajnalka E. , Han Cliff S. , Brettin Thomas S. , Progulske-Fox Ann 
Published: September 2015

ABSTRACT

Porphyromonas gingivalis
is strongly associated with periodontitis.
P. gingivalis
strain trafficking and tissue homing differ widely, even among presumptive closely related strains, such as W83 and A7436. Here, we present the genome sequence of A7436 with a single contig of 2,367,029 bp and a G+C content of 48.33%.
Draft Genome Sequence of Dichelobacter nodosus ATCC 25549, Strain VPI 2340 [11342], a Bacterium Causing Footrot in Sheep
Authors: Jackson Alexandra , Humbert María Victoria , Pandey Anish , Bratcher Holly , Christodoulides Myron 
Published: September 2015

ABSTRACT

We report a draft genome sequence for
Dichelobacter nodosus
ATCC 25549, strain VPI 2340 [11342], a causative agent of ovine footrot. The draft genome shares ~98% gene similarity with the available genome of
D. nodosus
strain VCS1703A but is differentiated by extensive gene duplication and the absence of 13 particular genes.
Near-Complete Genome Sequence of the Cellulolytic Bacterium
Bacteroides
(
Pseudobacteroides
)
cellulosolvens
ATCC 35603
Authors: Dassa Bareket , Utturkar Sagar , Hurt Richard A. , Klingeman Dawn M. , Keller Martin , Xu Jian , Reddy Y. Harish Kumar , Borovok Ilya , Rozman Grinberg Inna , Lamed Raphael , Zhivin Olga , Bayer Edward A. , Brown Steven D. 
Published: September 2015

ABSTRACT

We report the single-contig genome sequence of the anaerobic, mesophilic, cellulolytic bacterium,
Bacteroides cellulosolvens
. The bacterium produces a particularly elaborate cellulosome system, wherein the types of cohesin-dockerin interactions are opposite of other known cellulosome systems: cell-surface attachment is thus mediated via type-I interactions, whereas enzymes are integrated via type-II interactions.
Complete Genome Sequence of Rotavirus Group C Isolated in South Korea
Authors: Kim Dong-Uk , Park Kwi-Sung , Kim Jae-Kyung , Kang Shien-Young , Yoon Kyung-Ah 
Published: September 2015

ABSTRACT
Rotavirus group C is the major etiological agent associated with acute gastroenteritis in all human age groups. Here, we report the complete genome sequence of human group C rotavirus (GpC-RV) isolated in South Korea.
Draft Genome Sequence of the First NDM-1-Producing Providencia stuartii Strain Isolated in Portugal
Authors: Manageiro Vera , Sampaio Daniel A. , Pereira Patrícia , Rodrigues Paulo , Vieira Luís , Palos Carlos , Caniça Manuela 
Published: September 2015

ABSTRACT

We report here the draft genome sequence of the first NDM-1-producing
Providencia stuartii
strain isolated in Portugal. Sequence analyses revealed the presence of an incompatibility group A/C2 (IncA/C2) plasmid and of diverse acquired genes conferring resistance to β-lactams, aminoglycosides, tetracycline, macrolides, chloramphenicol, and sulfonamides. This sequence contributes to the evaluation of the spread of NDM-1 producers.
Complete Genome Sequences of Helicoverpa armigera Single Nucleopolyhedrovirus Strains AC53 and H25EA1 from Australia
Authors: Noune Christopher , Hauxwell Caroline 
Published: September 2015

ABSTRACT

We report here the genome sequences of two alphabaculoviruses of
Helicoverpa
spp. from Australia: AC53, used in the biopesticides ViVUS and ViVUS Max, and H25EA1, used in
in vitro
production studies.
Draft Genome Perspective of Staphylococcus saprophyticus Strain SU8, an
N
-Acyl Homoserine Lactone-Degrading Bacterium
Authors: Chan Kok-Gan , Sulaiman Joanita , Yong Delicia Ann , Tee Kok Keng , Yin Wai-Fong , Priya Kumutha 
Published: September 2015

ABSTRACT

Staphylococcus saprophyticus
strain SU8 was isolated from a pristine water source in Malaysia and it exhibited degradation of
N-
hexanoylhomoserine lactone. Here we report the draft genome sequence of
S. saprophyticus
strain SU8 to further understand its quorum quenching abilities.
Complete Genome Sequences of
Peach Latent Mosaic Viroid
from a Single Peach Cultivar
Authors: Jo Yeonhwa , Yoo Su-Hyun , Chu Hyosub , Cho Jin Kyong , Choi Hoseong , Yoon Ju-Yeon , Choi Seung-Kook , Cho Won Kyong 
Published: September 2015

ABSTRACT

Peach latent mosaic viroid
(PLMVd) is a member of the genus
Pelamoviroid
in the family
Avsunviroidae
and infects peach trees. We
de novo
assembled a PLMVd genome from a peach transcriptome and identified 18 variants in a single peach cultivar, after sequencing 20 PLMVd genomes by Sanger sequencing.
Draft Genome Sequence of a Pathogenic O86:H25 Sequence Type 57 Escherichia coli Strain Isolated from Poultry and Carrying 12 Acquired Antibiotic Resistance Genes
Authors: Jones-Dias Daniela , Manageiro Vera , Sampaio Daniel Ataíde , Vieira Luís , Caniça Manuela 
Published: September 2015

ABSTRACT

Escherichia coli
is a commensal bacterium that is frequently associated with multidrug-resistant zoonotic and foodborne infections. Here, we report the 5.6-Mbp draft genome sequence of an
E. coli
recovered from poultry, which encodes multiple acquired antibiotic resistance determinants, virulence factors, pathogenicity determinants, and mobile genetic elements.
Ras Signaling Is a Key Determinant for Metastatic Dissemination and Poor Survival of Luminal Breast Cancer Patients
Authors: Wright Katherine L. , Adams Jessica R. , Liu Jeff C. , Loch Amanda J. , Wong Ruth G. , Jo Christine E.B. , Beck Lauren A. , Santhanam Divya R. , Weiss Laura , Mei Xue , Lane Timothy F. , Koralov Sergei B. , Done Susan J. , Woodgett James R. , Zacksenhaus Eldad , Hu Pingzhao , Egan Sean E. 
Published: September 2015

AbstractBreast cancer is associated with alterations in a number of growth factor and hormone-regulated signaling pathways. Mouse models of metastatic breast cancer typically feature mutated oncoproteins that activate PI3K, Stat3, and Ras signaling, but the individual and combined roles of these pathways in breast cancer progression are poorly understood. In this study, we examined the relationship between oncogenic pathway activation and breast cancer subtype by analyzing mouse mammary tumor formation in which each pathway was activated singly or pairwise. All three oncogenes showed cooperation during primary tumor formation, but efficient dissemination was only dependent on Ras. In addition, transcriptional profiling demonstrated that Ras induced adenocarcinomas with molecular characteristics related to human basal-like and HER2+ tumors. In contrast, Ras combined with PIK3CAH1047R, an oncogenic mutant linked to ERα+/luminal breast cancer in humans, induced metastatic luminal B-like tumors. Consistent with these data, elevated Ras signaling was associated with basal-like and HER2+ subtype tumors in humans and showed a statistically significant negative association with estrogen receptor (ER) signaling across all breast cancer. Despite this, there are luminal tumors with elevated Ras signaling. Importantly, when considered as a continuous variable, Ras pathway activation was strongly linked to reduced survival of patients with ERα+ disease independent of PI3K or Stat3 activation. Therefore, our studies suggest that Ras activation is a key determinant for dissemination and poor prognosis of ERα+/luminal breast cancer in humans, and hormone therapy supplemented with Ras-targeting agents may be beneficial for treating this aggressive subtype. Cancer Res; 75(22); 4960–72. ©2015 AACR.
A Novel Quantitative Multiplex Tissue Immunoblotting for Biomarkers Predicts a Prostate Cancer Aggressive Phenotype
Authors: Zhu Guangjing , Liu Zhi , Epstein Jonathan I. , Davis Christine , Christudass Christhunesa S. , Carter H. Ballentine , Landis Patricia , Zhang Hui , Chung Joon-Yong , Hewitt Stephen M. , Miller M. Craig , Veltri Robert W. 
Published: September 2015

Abstract
Background: Early prediction of disease progression in men with very low-risk (VLR) prostate cancer who selected active surveillance (AS) rather than immediate treatment could reduce morbidity associated with overtreatment.
Methods: We evaluated the association of six biomarkers [Periostin, (−5, −7) proPSA, CACNA1D, HER2/neu, EZH2, and Ki-67] with different Gleason scores and biochemical recurrence (BCR) on prostate cancer TMAs of 80 radical prostatectomy (RP) cases. Multiplex tissue immunoblotting (MTI) was used to assess these biomarkers in cancer and adjacent benign areas of 5 μm sections. Multivariate logistic regression (MLR) was applied to model our results.
Results: In the RP cases, CACNA1D, HER2/neu, and Periostin expression were significantly correlated with aggressive phenotype in cancer areas. An MLR model in the cancer area yielded a ROC-AUC = 0.98, whereas in cancer-adjacent benign areas, yielded a ROC-AUC = 0.94. CACNA1D and HER2/neu expression combined with Gleason score in a MLR model yielded a ROC-AUC = 0.79 for BCR prediction. In the small biopsies from an AS cohort of 61 VLR cases, an MLR model for prediction of progressors at diagnosis retained (−5, −7) proPSA and CACNA1D, yielding a ROC-AUC of 0.78, which was improved to 0.82 after adding tPSA into the model.
Conclusions: The molecular profile of biomarkers is capable of accurately predicting aggressive prostate cancer on retrospective RP cases and identifying potential aggressive prostate cancer requiring immediate treatment on the AS diagnostic biopsy but limited in BCR prediction.
Impact: Comprehensive profiling of biomarkers using MTI predicts prostate cancer aggressive phenotype in RP and AS biopsies. Cancer Epidemiol Biomarkers Prev; 24(12); 1864–72. ©2015 AACR.
The Opposing Function of STAT3 as an Oncoprotein and Tumor Suppressor Is Dictated by the Expression Status of STAT3β in Esophageal Squamous Cell Carcinoma
Authors: Zhang Hai-Feng , Chen Ye , Wu Chengsheng , Wu Zhi-Yong , Tweardy David J. , Alshareef Abdulraheem , Liao Lian-Di , Xue Yu-Jie , Wu Jian-Yi , Chen Bo , Xu Xiu-E , Gopal Keshav , Gupta Nidhi , Li En-Min , Xu Li-Yan , Lai Raymond 
Published: September 2015

Abstract
Purpose: STAT3 is known to have both oncogenic and tumor suppressive effects, but the regulation of these opposing effects is elusive. We hypothesized that STAT3β, one of the two STAT3 isoforms, is the key determinant in this context.
Experimental Design: The prognostic significance of STAT3β and phospho-STAT3αY705 (pSTAT3αY705) was evaluated in 286 cases of patients with esophageal squamous cell carcinoma (ESCC). STAT3β-induced changes in the chemosensitivity to cisplatin and 5-fluorouracil were assessed both in vitro and in vivo. STAT3β-induced changes in the frequency of cancer stem cells were evaluated using Hoechst and CD44 staining. How STAT3β regulates STAT3α was determined using immunoprecipitation, confocal microscopy, DNA-binding, and chromatin immunoprecipitation-PCR.
Results: STAT3β expression is an independent protective prognostic marker in patients with ESCC, which strongly correlated with longer overall survival (P = 0.0009) and recurrence-free survival (P = 0.0001). STAT3β significantly decreased the cancer stem cell population, and sensitized ESCC cells to cisplatin and 5-fluorouracil in tumor xenografts. Mechanistically, STAT3β markedly attenuated the transcription activity of STAT3α via inducing STAT3α:STAT3β heterodimers. However, the heterodimer formation decreased the binding between STAT3α and PTPN9 (better known as PTP-MEG2), a protein tyrosine phosphatase, thereby promoting the phosphorylation of STAT3αY705 and enhancing its nuclear translocation and DNA binding. Correlating with this, high STAT3β expression converts the prognostic value of pSTAT3αY705 from unfavorable to favorable in patients with ESCC.
Conclusions: STAT3β suppresses chemoresistance and cancer stemness by blocking the transcriptional activity of STAT3α. The paradoxical increase in pSTAT3αY705 induced by STAT3β carries important implications as to how the biologic and prognostic significance of STAT3 in cancers should be interpreted. Clin Cancer Res; 22(3); 691–703. ©2015 AACR.
Clues to the chronology of Old Germanic loans in Romanian and in other South-East European languages
Authors: Poruciuc Adrian 
Published: September 2015

Clues to the chronology of Old Germanic loans in Romanian and in other South-East European languagesThe present article is directly based on the handout of the talk this author gave at the International Conference on Balkan Linguistics (6-7 May, 2013, Toruń, Nicolaus Copernicus University); therefore the subchapters and paragraphs observe the arrangement of the materials included in that handout. The first part contains a chronological table that reflects mainstream archaeological-historical information regarding the history of military-political actions and achievements of the Old Germanic populations in south-east Europe between the 3rd century BC and the 6th century of our era. Then concrete textual proofs follow, which are chronologically arranged and briefly commented upon. Finally, the author proposes interdisciplinary approaches based mainly on reference of linguistic features to historical stages and evolutions. Źródła danych do ustalenia chronologii pożyczek starogermańskich w języku rumuńskim i w innych językach Europy południowo-wschodniejArtykuł przygotowano w oparciu o dane zamieszczone w materiałach do referatu na konferencję „International Conference on Balkan Linguistics” (6-7 maja 2013, Toruń, Uniwersytet Mikołaja Kopernika); porządek poszczególnych podsekcji i paragrafów artykułu jest zatem zgodny ze strukturą tej prezentacji. Część pierwsza zawiera chronologiczne przedstawienie istotnych materiałów archeologiczno-historycznych na temat działań o charakterze militarno-politycznym oraz zdobyczy ludów starogermańskich w Europie południowo-wschodniej w okresie od III w. p.n.e. do VI w. n.e. W dalszej części przytoczono i krótko skomentowano uporządkowane chronologicznie konkretne dowody językowe. Na końcu znajduje się propozycja interdyscyplinarnego podejścia do tematu, oparta głównie na odniesieniu cech językowych do odpowiednich etapów historii i ewolucji językowej.
Implications of macro-areal linguistics
Authors: Leschber Corinna 
Published: September 2015

Implications of macro-areal linguisticsUsing the examples of some Balkan words with a difficult etymology, we attempt to show the possibilities for and implications of applying a macro-areal linguistic perspective to establish a wider view of the linguistic and cultural history of a region. Implikacje językoznawstwa makroarealnegoNa przykładzie niektórych bałkańskich słów o skomplikowanej etymologii autorka dokonuje próby pokazania możliwości i potencjału badawczego perspektywy makroarealnej. W każdym wypadku daje ona głębszy wgląd w historię, rozwój językowy i kulturowy tego regionu.