bluuebunny/crossref_metadata_2025_split huggingface dataset:
From constitutional to human rights: On the moral structure of international human rights
Authors: MÖLLER KAI 
Published: September 2014

AbstractThe paper presents a theory of the moral structure of international human rights. It proceeds by drawing on recent scholarship on the philosophy of national constitutional rights, which has shown that there is now an emerging global consensus on certain structural features of constitutional rights; in previous work I have summarized this under the label ‘the global model of constitutional rights’. Starting from the theory of rights underlying the global model, the paper asks what modifications, if any, are required to turn that theory into a suitable theory of international human rights. In particular, it examines the widely held view that international human rights are more minimalist than national constitutional rights. Discussing recent work by Ronald Dworkin (on political/constitutional versus human rights) and Joseph Raz (on legitimate authority versus national sovereignty), the paper concludes that it is not possible to make rights more minimalist than they already are under the global model. It follows that the moral structures of national constitutional rights and international human rights are identical. The final section of the paper examines some implications of this result, addressing the issues of the workability of the proposed conception of international human rights in practice, its point and purpose, and discussing the obligations of states to participate in international mechanisms for the protection of human rights.
A sensitive method for the quantification of virion-sense and complementary-sense DNA strands of circular single-stranded DNA viruses
Authors: Rodríguez-Negrete Edgar A. , Sánchez-Campos Sonia , Cañizares M. Carmen , Navas-Castillo Jesús , Moriones Enrique , Bejarano Eduardo R. , Grande-Pérez Ana 
Published: September 2014

AbstractCircular single-stranded DNA (ssDNA) viruses are the smallest viruses known to infect eukaryotes. High recombination and mutation rates have conferred these viruses with an evolutionary potential that has facilitated their emergence. Their damaging effects on livestock (circoviruses) and crops (geminiviruses and nanoviruses) and the ubiquity of anelloviruses in human populations and other mammalian species, have resulted in increased interest in better understanding their epidemiology and infection mechanisms. Circular ssDNA viral replication involves the synthesis of dsDNA intermediates containing complementary-sense (CS) and virion-sense (VS) strands. Precise quantification of VS and CS accumulation during viral infections can provide insights into the molecular mechanisms underlying viral replication and the host invasion process. Although qPCR protocols for quantifying viral molecules exist, none of them discriminate VS and CS strands. Here, using a two-step qPCR protocol we have quantified VS and CS molecule accumulation during the infection process of Tomato yellow leaf curl virus (TYLCV) and Tomato yellow leaf curl Sardinia virus (TYLCSV) (genus Begomovirus, family Geminiviridae). Our results show that the VS/CS strand ratio and overall dsDNA amounts vary throughout the infection process. Moreover, we show that these values depend on the virus-host combination and that most CS strands are present as double-stranded molecules.
RAMONA: a Web application for gene set analysis on multilevel omics data
Authors: Sass Steffen , Buettner Florian , Mueller Nikola S. , Theis Fabian J. 
Published: September 2014

Abstract
Summary: Decreasing costs of modern high-throughput experiments allow for the simultaneous analysis of altered gene activity on various molecular levels. However, these multi-omics approaches lead to a large amount of data, which is hard to interpret for a non-bioinformatician. Here, we present the r emotely a ccessible m ultilevel on tology a nalysis (RAMONA). It offers an easy-to-use interface for the simultaneous gene set analysis of combined omics datasets and is an extension of the previously introduced MONA approach. RAMONA is based on a Bayesian enrichment method for the inference of overrepresented biological processes among given gene sets. Overrepresentation is quantified by interpretable term probabilities. It is able to handle data from various molecular levels, while in parallel coping with redundancies arising from gene set overlaps and related multiple testing problems. The comprehensive output of RAMONA is easy to interpret and thus allows for functional insight into the affected biological processes. With RAMONA, we provide an efficient implementation of the Bayesian inference problem such that ontologies consisting of thousands of terms can be processed in the order of seconds.
Availability and implementation: RAMONA is implemented as ASP.NET Web application and publicly available at http://icb.helmholtz-muenchen.de/ramona .
Contact: fabian.theis@helmholtz-muenchen.de
Angiography for Management of Perioperative Myocardial Ischemia: Does it Have Any Role?
Authors: Narayan Pradeep , Bandyopadhyay Manujesh , Khan Mohammed Wasim , Sarkar Kunal 
Published: September 2014

Objective Perioperative myocardial ischemia (PMI) is a relatively rare but potentially fatal complication after coronary artery bypass grafting and is due to graft-related problems in a significant proportion of cases. The usual indicators of MI in the postoperative setting are unreliable and therefore have uncertain diagnostic value. Angiography, the criterion standard for preoperative angina, remains underused for evaluation of PMI. The aim of this study was to evaluate the role of angiography in the management of PMI. Methods Between January 2011 and September 2012, a total of 2312 isolated primary consecutive coronary artery bypass graft surgeries were performed, of which 2057 (89%) were carried out on the beating heart. Twenty-six (1.12%) of these patients needed perioperative angiography. The patients needing angiography were selected on the basis of a number of clinical, biochemical, and other diagnostic parameters Results Twenty-six patients with PMI required angiography, of which 18 (69 %) were found to have graft-related issues. The mean (SD) time between operation and angiography was 24.58 (6.71) hours. Of the 18 patients, 17 (94.44%) required surgical intervention and 1 patient was treated with angioplasty. There were 2 deaths (11.1%) in the group undergoing intervention. Angiographic findings included occluded vein graft (n = 7), narrowing of the left internal mammary artery (n = 3), and kinking or stretching of grafts (n = 8). Conclusions Angiography is useful in diagnosing graft-related problems in the perioperative period. In presence of signs of graft compromise, we suggest that having a low threshold for angiographic graft evaluation may be beneficial in a carefully selected subset of patients after coronary artery bypass.
Midterm Outcomes after Transcatheter Aortic Valve Implantation
Authors: Lotfi Shahram , Dohmen Guido , Götzenich Andreas , Haushofer Marcus , Spillner Jan Wilhelm , Autschbach Rüdiger , Hoffmann Rainer 
Published: September 2014

Objective Transcatheter aortic valve implantation (TAVI) has become a therapeutic option for high-risk or nonoperable patients with severe symptomatic aortic valve stenosis. The best known and most frequently implanted prostheses are the CoreValve and SAPIEN prostheses. We report our experiences and analyze the results of our TAVI program. Methods A total of 357 patients underwent transfemoral (TF) and transapical (TA) TAVI in our center between January 2008 and October 2012. The procedure was performed in 190 patients with CoreValve, in 155 patients with SAPIEN, and in 12 patients with ACURATE TA prostheses. Transfemoral access was used in 190 patients. In 167 patients, TA access was used. The mean age was 80.2 ± 6.4 years. All patients were nonoperable or had a high risk for a conventional aortic valve replacement. The mean logistic EuroSCORE I was 25.92 ± 14.51%. The TF/CoreValve (190 patients) and TA/SAPIEN (155 patients) groups showed significant difference in the patients’ mean age (81.7 ± 6.3 years vs. 79.5 ± 6.6 years, P = 0.002) and in mean logistic EuroSCORE I (22.16 ± 13.05% vs. 31.04 ± 16.40, P < 0.001). Results The overall 30-day mortality (357 patients) was 9.80% (TF, 8.42%; TA, 11.37%); overall 1-year mortality (275 patients), 21.45% (TF, 23.74%; TA, 19.12%); overall 2-year mortality (199 patients), 29.15% (TF, 35.96%; TA, 23.64%); overall 3-year mortality (133 patients), 37.59% (TF, 43.86%; TA, 32.89%); and overall 4-year mortality (38 patients), 39.47% (TF, 45%; TA, 33.33%). The rate of pacemaker implantation after TAVI was significantly higher in the CoreValve group than in the SAPIEN group: 44.74% (85/190 patients) versus 6.45% (10/155 patients), P < 0.001. Stroke rate was higher in the TF-CoreValve group than in the TA-SAPIEN group: 4.21% versus 0.64%, P = 0.045. Conclusions Outcomes after TAVI were, in our population of nonoperable and high-risk patients, encouraging. The differences in midterm outcomes between the TF-CoreValve TAVI and the TA-SAPIEN TAVI were not significant.
Origins and impacts of new mammalian exons
Authors: Merkin Jason , Chen Ping , Alexis Maria , Hautaniemi Sampsa , Burge Christopher B. 
Published: September 2014

SummaryMammalian genes are composed of exons, but the evolutionary origins and functions of new internal exons are poorly understood. Here, we analyzed patterns of exon gain using deep cDNA sequencing data from five mammals and one bird, identifying thousands of species- and lineage-specific exons. Most new exons derived from unique rather than repetitive intronic sequence. Unlike exons conserved across mammals, species-specific internal exons were mostly located in 5′ untranslated regions and alternatively spliced. They were associated with upstream intronic deletions, increased nucleosome occupancy, and RNA polymerase II pausing. Genes containing new internal exons had increased gene expression, but only in tissues where the exon was included. Increased expression correlated with level of exon inclusion, promoter proximity, and signatures of cotranscriptional splicing. Together these findings suggest that splicing at the 5′ ends of genes enhances expression and that changes in 5′ end splicing alter gene expression between tissues and between species.
Pinwheel-dipole configuration in cat early visual cortex
Authors: Ribot Jérôme , Romagnoni Alberto , Milleret Chantal , Bennequin Daniel , Touboul Jonathan 
Published: September 2014

ABSTRACTIn the early visual cortex, information is processed within functional maps whose layouts are thought to underlie visual perception. However, the precise organization of these functional maps as well as their interrelationships remains largely unknown. Here, we show that spatial frequency representation in cat early visual cortex exhibits singularities around which the map organizes like an electric dipole potential. These singularities are precisely co-located with singularities of the orientation map: the pinwheel centers. To show this, we used high resolution intrinsic optical imaging in cat areas 17 and 18. First, we show that a majority of pinwheel centers exhibit in their neighborhood both semi-global maximum and minimum in the spatial frequency map, contradicting pioneering studies suggesting that pinwheel centers are placed at the locus of a single spatial frequency extremum. Based on an analogy with electromagnetism, we proposed a mathematical model for a dipolar structure, accurately fitting optical imaging data. We conclude that a majority of orientation pinwheel centers form spatial frequency dipoles in cat early visual cortex. Given the functional specificities of neurons at singularities in the visual cortex, it is argued that the dipolar organization of spatial frequency around pinwheel centers could be fundamental for visual processing.ABBREVIATIONSOROrientationSFSpatial frequencyPCPinwheel centerA17Area 17A18Area 18
Self-fertilization and 1 inbreeding limit the scope for sexual antagonism
Authors: Tazzyman Samuel J. , Abbott Jessica K. 
Published: September 2014

AbstractSexual antagonism occurs when there is a positive intersexual genetic correlation in trait expression but opposite fitness effects of the trait(s) in males and females. As such, it constrains the evolution of sexual dimorphism and may therefore have implications for adaptive evolution. There is currently considerable evidence for the existence of sexually antagonistic genetic variation in laboratory and natural populations, but how sexual antagonism interacts with other evolutionary phenomena is still poorly understood in many cases. Here we explore how self-fertilization and inbreeding affect the maintenance of polymorphism for sexually antagonistic loci. We expecteda priorithat selfing should reduce the region of polymorphism, since inbreeding reduces the frequency of heterozygotes and speeds fixation. Although this expectation was supported, our results show that there is an interactive effect between the degree of selfing and dominance such that those segregating sexually antagonistic loci that do exist are more likely to be partially dominant. In addition, inbreeding effects may influence population persistence and genomic location of sexually antagonistic loci in separate-sexed organisms.
Aspects of intergranular corrosion of AISI 321 stainless steel in high-carbon-containing environments
Authors: Ryl Jacek , Arutunow Anna , T. Tobiszewski Mateusz , Wysocka Joanna 
Published: September 2014

Purpose
– The purpose of this paper is to present a case study of unexpected sensitization to intergranular corrosion of highly resistant AISI 321 steel in petrochemical conditions, where it was subjected to the simultaneous influence of elevated temperature of ∼250°C and vapors from the asphalt production process.

Design/methodology/approach
– Corrosion coupons were exposed in an installation carrying asphalt vapors. To identify the susceptibility to intergranular corrosion a standard Strauss test was performed. Scanning electron microscopy (SEM) micrographs show a degree of degradation as a result of local corrosion. Influence of the carburization process occurred during exposure and depletion of chromium in the passive layer and was evaluated using X-ray photoelectron spectroscopy (XPS) and X-ray spectroscopy (EDX) techniques.

Findings
– The paper provides information on origin of corrosion of AISI 321 steel in a high-carbon-containing environment. It was found out that long-term exposure can lead to intergranular corrosion in temperatures that are much lower than those that have been considered to be required for sensitization of austenitic steels. The high concentration of carbon introduced during the exposure is stated to be responsible for this effect.

Practical implications
– The formation of chromium carbides, leading to intergranular corrosion of the Type 321 stainless steel, is a major concern. The paper reports that in certain petrochemical environments, highly resistant stainless steels, such as AISI 321, can be susceptible to intergranular carbide degradation.

Originality/value
– The presence of titanium is not sufficient to increase resistance in multiple environments and sensitization can occur even at relatively low temperatures of ∼250°C.
Corrosion mechanism in a closed-loop oscillating heat-pipe with check valves (CLOHP/CV)
Authors: Sangiamsuk S. , Bubphachot B. , Watanabe O. , Rittidech S. 
Published: September 2014

Purpose
– The purpose of this paper was to study the parameters affecting corrosion of the closed-loop oscillating heat-pipe with check valves (CLOHP/CV) in a system in clear that will be basic data to be used in future research. The majority of research focuses on the inner surface corrosion heat-pipe systems. The CLOHP/CV is commonly favored in cooling electronic devices, etc. Despite these common applications, limited reliable experimental research findings are available on the operation of the CLOHP/CV. Because of these reasons, the lack of detailed data, working fluids effect, working temperatures and duration of testing of the CLOHP/CV, this study focuses on determining the actual inner surface corrosion.

Design/methodology/approach
– Seven types of copper tubes used in the CLOHP/CV set were sectioned to observe their inner surfaces. Seven different specimens with tube corrosion were examined by a visual inspection, scanning electron microscopy (SEM) and energy dispersive X-ray spectrometry (EDX). The technique for detecting metals solution in samples is based on the fact that ground state metals absorb light at specific wavelengths. Metal ions in a solution are converted to atomic state by means of a flame. In this study, concentration of copper particle in the working fluid was found by flame atomic absorption spectroscopy (Flame-AAS) and elements that occurred on inner surface tube were analyzed by EDX.

Findings
– The analyses with SEM and EDX testing found that the character corrosion of inner surface of CLOHP/CV was pitting clearly. The analysis with Flame-AAS found that the concentration of copper particles in the distilled water and ethanol as working fluid is more than after 1,000 hours until 3,000 hours because of excess volume of oxygen in working fluid which causes many reactions at the beginning. When the oxygen decreases after 1,000 hours, it causes the reaction to decrease too and get the most concentration of copper particles, i.e. 18.57228 ppm or 0.40859 mg.

Originality/value
– Corrosion-dependant maintenance must also be factored into the design. Producing reliable equipment that will become standardized and fixing the time for proper maintenance will require individuals that are knowledgeable about the materials that are going to be used in the design of such equipment. Nowadays, the lack of detailed data of working fluids effect, working temperatures and duration of testing of the CLOHP/CV focuses on determining the actual inner surface corrosion. Therefore, this research aimed to study the parameters affecting corrosion of the CLOHP/CV in a system in clear that will be basic data to be used in future research.
Corrosion inhibition of bronze alloy B66 by 4-amino-3-methyl-1,2,4-triazole-5-thione in 3 per cent NaCl solution
Authors: Chebabe Driss , Dermaj Ahmed , Erramli Hamid , Hajjaji Najat 
Published: September 2014

Purpose
– The purpose of this study is to study corrosion inhibition of Bronze alloy B66 by 4-amino-3-methyl-1,2,4-triazole-5-thione (MTSNH) in 3 per cent NaCl solution. Archaeological bronze artefacts often are stored or displayed in uncontrolled conditions and may suffer from dangerous active corrosion processes that can lead to their destruction. The most dangerous form of archaeological bronze degradation is due to a cyclic reaction that involves copper from the pure alloy and chlorine as a pathogenic agent. A protection treatment can be used to protect them from the corrosion environment and stabilise them to avoid further degradation during exhibition or storage. Starting from its initial assessment as a corrosion inhibitor for pure copper, nowadays benzotriazole (BTA) is in widespread use for the conservation of copper-based artefacts, but unfortunately, BTA is toxic and a suspected carcinogen. The development of new and safe protection systems would offer a choice of alternative products to conservation-restoration professionals for the effective and safe stabilization and protection of metal artefacts. In this investigation, a new organic compound, namely, MTSNH, was synthesized, characterized and tested as a corrosion inhibitor for Bronze B66 (similar to archaeological bronze) in 3 per cent NaCl solution using potentiodynamic polarization studies and electrochemical impedance spectroscopy (EIS) at room temperature. It has been observed from the corrosion rate that the inhibition efficiency increased with increasing concentration of MTSNH. Potentiodynamic polarisation results revealed that the compound acted as a mixed-type inhibitor. Impedance studies indicated that protection occurs through adsorption of the inhibitor on the metal surface, with important modification to the mechanism of corrosion. Surface analysis was carried out using scanning electron microscopy scanning electron microscopy (SEM)/energy dispersive spectrometry (EDX) techniques to verify the electrochemical results.

Design/methodology/approach
– The inhibition efficiency of MTSNH is investigated by potentiodynamic polarization, EIS and surface analysis.

Findings
– The synthesized MTSNH act a good inhibitor in 3 per cent NaCl and inhibition efficiency increases with inhibitor concentration. Polarisation curves showed that the inhibitor is mixed. The EIS measurements showed that the inhibitor acted throughout the formation of film at the bronze surface. The surface analysis confirms this result.

Originality/value
– The adsorption of the MTSNH on the metal surface can markedly change the corrosion resisting property of metal. Therefore, the study of the relation between adsorption and corrosion inhibiting is of a great importance.
The art of branding − lessons from visual artists
Authors: L. Rodner Victoria , Kerrigan Finola 
Published: September 2014

Purpose
– The purpose of this paper is to highlight the importance of the field of visual arts marketing in the development of wider branding theory and practice. Drawing on examples from visual artists and the art mechanism that connects them, the paper reveals how artists and art professionals foster various types of capital (social, cultural, symbolic) as a way of developing a brand name, ensuring longevity in the field, and gaining financial value on the market.

Design/methodology/approach
– As a conceptual paper, the authors draw on a range of published works as well as examples from the world of visual arts in order to provide fresh theoretical insight into how branding in the arts may be applied to other industries.

Findings
– The key findings are the importance of the consideration of the development and nurturing of social and cultural capital in developing brand identity. Additionally, visual art brands are required to be innovative and dynamic, and lessons learned regarding these processes have relevance for mainstream brands. The paper also found that creativity is often collective and that looking to methods for developing work in the visual arts can be utilised by brand managers more broadly in the age of social media and user generated content.

Originality/value
– This paper follows on the developing body of work, which indicates what mainstream business can learn from looking at the visual arts. The paper highlights the collective nature of creativity in building the art brand as well as the importance of non-economic measures of value in the realm of branding.