bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Simplified Procedure for TEMPO‐Catalyzed Oxidation: Selective Oxidation of Alcohols, α‐Hydroxy Esters, and Amides Using TEMPO and Calcium Hypochlorite.
Authors: Reddy Sabbasani Rajasekhara , Stella Selvaraj , Chadha Anju 
Published: August 2013

AbstractThe method presented does not require any transition metals, acids or bases and demonstrates controlled and selective oxidation of structurally diverse alcohols.
ChemInform Abstract: Gallium Tribromide Catalyzed Coupling Reaction of Alkenyl Ethers with Ketene Silyl Acetals.
Authors: Nishimoto Yoshihiro , Ueda Hiroki , Yasuda Makoto , Baba Akio 
Published: August 2013

AbstractThe title reaction is accomplished for various types of alkenyl ethers and ketene silyl acetals.
ChemInform Abstract: Diastereoselective Liquid Assisted Grinding: “Cracking” Functional Resins to Advance Chromatography‐Free Synthesis.
Authors: Shearouse William C. , Mack James 
Published: August 2013

AbstractThe report details the use of ball milling and the use of a polymer‐bound reagent to perform an evironmentally attractive version of the Wittig‐reaction.
ChemInform Abstract: Multidirectional Cobalt‐Catalyzed Diels—Alder/1,4‐Hydrovinylation Sequences.
Authors: Erver Florian , Kuttner Julian R. , Hilt Gerhard 
Published: August 2013

AbstractCoBr2(dppe)‐catalyzed treatment of enynes of type (I) with the diene (II) followed by oxidation is found to result in formation of polysubstituted benzenes like (III).
ChemInform Abstract: Triphenylphosphine as a Ligand for the Pd‐Catalyzed Amination of Unactivated Aryl Chlorides with Anilines Promoted by Salicylaldimine.
Authors: Liu Tao‐Ping , Cheng Qiang , Song Wen‐Jing , Cai Liang‐Zhen , Tao Xiao‐Chun 
Published: August 2013

AbstractThe selective amination of aryl chlorides with anilines for the preparation of diarylamines is catalyzed by a mixed ligand catalytic system of Pd/PPh3/salicylaldimine.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Homoenolate‐Addition Reaction of Enals and Nitroalkenes: Asymmetric Synthesis of 5‐Carbon‐Synthon δ‐Nitroesters.
Authors: Maji Biswajit , Ji Li , Wang Siming , Vedachalam Seenuvasan , Ganguly Rakesh , Liu Xue‐Wei 
Published: August 2013

AbstractThe title reaction employs catalytic amounts of N‐heterocyclic carbene precursors and transforms a broad range of nitroalkenes, such as nitrodienes, nitroenynes, and nitrostyrenes, through reaction with a broad range of enals, into δ‐nitroesters.
ChemInform Abstract: 1‐(α‐Aminobenzyl)‐2‐naphthol as Phosphine‐Free Ligand for Pd‐Catalyzed Suzuki and One‐Pot Wittig—Suzuki Reaction.
Authors: Chaudhary A. R. , Bedekar A. V. 
Published: August 2013

AbstractAn air stable and easily accessible ligand is successfully applied to the Suzuki reaction for a variety of substrates and to a novel and efficient one‐pot two‐step cascade Wittig‐Suzuki reaction.
ChemInform Abstract: Suzuki—Miyaura Coupling of Aryl Iodides, Bromides, and Chlorides Catalyzed by Bis(thiazole) Pincer Palladium Complexes.
Authors: Luo Qun‐Li , Tan Jian‐Ping , Li Zhi‐Fu , Nan Wen‐Hui , Xiao Dong‐Rong 
Published: August 2013

AbstractUsing the title method, the key intermediate (VIII) of the luteinizing hormone receptor antagonist LUF5771 can be prepared in high yields.
ChemInform Abstract: Novel Task‐Specific Ionic Liquids as Solvents for Michael Addition of Methylene Active Compounds to Chalcones Without Any Catalyst.
Authors: Ying An‐Guo , Chen Xin‐Zhi , Wu Cheng‐Lin , Zheng Ren‐Hua , Liang Hua‐Ding , Ge Chang‐Hua 
Published: August 2013

AbstractA convenient and facile method for the Michael addition of active methylene compounds to chalcones is developed using DBU‐derived task‐specific ionic liquids as reaction medium.
ChemInform Abstract: Asymmetric Epoxidation of Conjugated Olefins with Dioxygen.
Authors: Koya Shota , Nishioka Yota , Mizoguchi Hirotaka , Uchida Tatsuya , Katsuki Tsutomu 
Published: August 2013

AbstractThe asymmetric epoxidation of conjugated olefins is achieved at room temperature using an (aqua)ruthenium(salen) complex as catalyst and air as the oxidant to give epoxides in up to 95% e.e.
ChemInform Abstract: Direct Asymmetric Vinylogous Mannich Reaction of 3,4‐Dihalofuran‐2(5H)‐one with Aldimine Catalyzed by Quinine.
Authors: Guo Yun‐Long , Bai Jian‐Fei , Peng Lin , Wang Liang‐Liang , Jia Li‐Na , Luo Xi‐Ya , Tian Fang , Xu Xiao‐Ying , Wang Li‐Xin 
Published: August 2013

AbstractFuranones of type (III) are useful synthons which can be converted into optically active butyrolactones such as (IV) and amino diols like (V).
ChemInform Abstract: CuO/CNTs‐Catalyzed Heterogeneous Process: A Convenient Strategy to Prepare Furan Derivatives from Electron‐Deficient Alkynes and α‐Hydroxy Ketones.
Authors: Cao Hua , Jiang Huan‐Feng , Zhou Xiao‐Song , Qi Chao‐Rong , Lin Yuan‐Guang , Wu Jian‐Yong , Liang Qi‐Mei 
Published: August 2013

AbstractCarbon nanotube supported CuO is synthesized and applied as highly active and reusable heterogeneous catalyst for the construction of highly substituted furan derivatives (III).
ChemInform Abstract: Deciphering DNA‐Based Asymmetric Catalysis Through Intramolecular Friedel—Crafts Alkylations.
Authors: Park Soyoung , Ikehata Keiichi , Watabe Ryo , Hidaka Yuta , Rajendran Arivazhagan , Sugiyama Hiroshi 
Published: August 2013

AbstractThe combination of DNA and a copper‐phenanthroline complex is tested as a catalytic system for the asymmetric intramolecular Friedel—Crafts alkylation of indoles (I).
ChemInform Abstract: One‐Pot Approach to Installing Eight‐Membered Rings onto Indoles.
Authors: Zhu Can , Zhang Xue , Lian Xiongdong , Ma Shengming 
Published: August 2013

AbstractOne‐pot procedure for the synthesis of dihydrocycloocta[b]indoles from 2‐allyl‐3‐iodoindoles and propargyl bromides proceeds through Pd‐catalyzed C—C coupling, [1,5]hydrogen migration and electrocyclization.
ChemInform Abstract: A Practical and Efficient Synthesis of 2,5‐Disubstituted‐3,5‐dihydro‐imidazol‐4‐ones from Oxazolones.
Authors: Chavez Flavio , Pavy Caslin , Williamson Thomas , Cleary Thomas 
Published: August 2013

AbstractA practical and efficient method for the synthesis of 2,5‐disubstituted‐3,5‐dihydro‐imidazol‐4‐ones (II) is developed.
ChemInform Abstract: Enantioselective Conjugate Addition of Alkylboranes Catalyzed by a Copper—N‐Heterocyclic Carbene Complex.
Authors: Yoshida Mika , Ohmiya Hirohisa , Sawamura Masaya 
Published: August 2013

AbstractFor the first time the title reaction is developed in a catalytic manner by using a new chiral imidazolium salt.
ChemInform Abstract: Synthesis and Evaluation of Some Novel 2,4‐Thiazolidinedione Derivatives for Antibacterial, Antitubercular and Antidiabetic Activities.
Authors: Pattan Shashikant , Kedar Manisha , Pattan Jayashri , Dengale Santosh , Sanap Manjusha , Gharate Utkarsha , Shinde Punam , Kadam Sushma 
Published: August 2013

AbstractAll of the synthesized thiazolidinedione (IX) and (XI) show promising antibacterial, antitubercular and antidiabetic activities in comparison to the standard drugs norfloxacin, streptomycin and glibenclamide, respectively.
ChemInform Abstract: Synthesis, Characterization and Structure Optimization of a Series of Thiazolidinone Derivatives as Entamoeba histolytica Inhibitors.
Authors: Mushtaque Md. , Avecilla Fernando , Azam Amir 
Published: August 2013

AbstractThiazolidinone derivatives (V) are synthesized and evaluated for their in vitro antiamoebic activity against the HM1:IMSS strain of Entamoeba histolytica. Compounds (V) exhibit promising potency with IC50 values lower than the standard drug metronidazole.
ChemInform Abstract: Ligand‐Free Copper Powder Catalyzed Direct Coupling Reaction of Heterocyclic C—H Bonds and Aryl Halides.
Authors: Han Ying , Wang Xiaohu , Wang Xiaowei , Lv Liangzhong , Diao Guowang , Yuan Yu 
Published: August 2013

AbstractBenzothiazole (II) and benzoxazole (VI) can be efficiently coupled with aryl iodides under optimized conditions A).
ChemInform Abstract: Asymmetric Syntheses of 8‐Oxabicyclo[3,2,1]octanes: A Cationic Cascade Cyclization.
Authors: Li Bin , Zhao Yu‐Jun , Lai Yin‐Chang , Loh Teck‐Peng 
Published: August 2013

AbstractA novel, practical, mild, and efficient diastereoselective synthesis of the title compounds is developed.
ChemInform Abstract: New Syntheses of 3‐Aroylflavone Derivatives; Knoevenagel Condensation and Oxidation versus One‐Pot Synthesis.
Authors: Vaz Patricia A. A. M. , Pinto Diana C. G. A. , Rocha Djenisa H. A. , Silva Artur M. S. , Cavaleiro Jose A. S. 
Published: August 2013

AbstractTwo methodologies are developed to perform the synthesis of 3‐aroylflavones.
ChemInform Abstract: Palladium‐Catalyzed Domino Carbopalladation/C—H Activation for the Synthesis of Tetrasubstituted Alkenes Bearing Five‐ and Seven‐Membered Rings.
Authors: Tietze Lutz F. , Hungerland Tim , Depken Christian , Maass Christian , Stalke Dietmar 
Published: August 2013

AbstractPropargylic alcohols (I) afford tetrasubstituted alkenes having a dihydroindene‐ or a benzo[7]annulene motif.
ChemInform Abstract: Synthesis and Evaluation of Novel 2‐Pyridone Derivatives as Inhibitors of Phosphodiesterase3 (PDE3): A Target for Heart Failure and Platelet Aggregation.
Authors: Ravinder Mettu , Mahendar Budde , Mattapally Saidulu , Hamsini Kommi Venkata , Reddy Thatikonda Narendar , Rohit Chilappa , Srinivas Kolupula , Banerjee Sanjay Kumar , Rao Vaidya Jayathirtha 
Published: August 2013

Abstract26 Pyridone derivatives of type (IV) are prepared and tested as inhibitors of phosphodiesterase3 (PDE3).
ChemInform Abstract: Design, Solvent Free Synthesis, and Antimicrobial Evaluation of 1,4‐Dihydropyridines.
Authors: Murthy Y. L. N. , Rajack Abdul , Ramji M. Taraka , Jeson babu J. , Praveen Ch. , Lakshmi K. Aruna 
Published: August 2013

AbstractOptimum reaction conditions are examined for the synthesis of 1,4‐dihydropyridines using cellulose sulfuric acid as catalyst.
ChemInform Abstract: Synthesis and Cytotoxicity of New Quinoline Derivatives.
Authors: Meshram H. M. , Reddy B. Chennakesava , Kumar D. Aravind , Kalyan M. , Ramesh P. , Kavitha P. , Rao J. Venkateswara 
Published: August 2013

AbstractThe title compounds are obtained from 4‐haloquinoline (I) following the Suzuki protocol.
ChemInform Abstract: Copper‐Catalyzed Tandem Synthesis of Indolo‐, Pyrrolo[2,1‐a]isoquinolines, Naphthyridines and Bisindolo/Pyrrolo[2,1‐a]isoquinolines via Hydroamination of ortho‐Haloarylalkynes Followed by C‐2 Arylation.
Authors: Verma Akhilesh K. , Jha Rajeev R. , Chaudhary Ritu , Tiwari Rakesh K. , Reddy Kotla Siva K. , Danodia Abhinandan 
Published: August 2013

AbstractThe title compounds are of biological and electronic interest.
ChemInform Abstract: Copper‐Catalyzed Aerobic Dehydrogenative Cyclization of N‐Methyl‐N‐phenylhydrazones: Synthesis of Cinnolines.
Authors: Zhang Guangwu , Miao Jinmin , Zhao Yan , Ge Haibo 
Published: August 2013

AbstractN‐Phenylhydrazones as novel substrates for copper‐catalyzed aerobic intramolecular dehydrogenative cyclization are presented.
ChemInform Abstract: Ring Opening of Cyclic Sulfamidates with Magnesiated Heterocycles: Expedient Synthesis of Highly Functionalized Azaindolines and Azatetrahydroquinolines.
Authors: Moss Thomas A. , Hayter Barry R. , Hollingsworth Ian A. , Nowak Thorsten 
Published: August 2013

AbstractAzaindolines (III) and azatetrahydroquinolines (V) are prepared in a stereo‐predictable manner via ring opening of cyclic sulfamidates with metalated chloro heterocycles, followed by intramolecular cyclization upon basification of the adducts.
ChemInform Abstract: Vanadium‐Catalyzed Oxidation of tert‐Butyl N‐Hydroxycarbamate to tert‐Butyl Nitrosoformate and Its Diels—Alder Reaction with Simple and Functionalized Dienes.
Authors: Hoshino Yujiro , Suzuki Kenzo , Honda Kiyoshi 
Published: August 2013

AbstractThe vanadium‐catalyzed oxidation of carbamate (II), followed by alkyl hydroperoxides as terminal oxidants, affords an intermediate nitroso compound.
ChemInform Abstract: Synthesis of 4‐Aryl‐4‐methyl‐ and 4,4‐Dimethyl‐4H‐pyrrolo[2,1‐c][1,4]benzothiazines by an Easy Five‐Step Sequence Starting from 2‐Sulfanylbenzenamines.
Authors: Kobayashi Kazuhiro , Hyota Akane , Kondo Hideaki , Imaoka Ayumi 
Published: August 2013

AbstractPrecursor (XII) is prepared analogously to (VII) following the sequence A)‐D).
ChemInform Abstract: 1‐(2‐Mercaptobenzenesulfonyl)‐3‐hydroxyguanidines — Novel Potent Antiproliferatives, Synthesis and in vitro Biological Activity.
Authors: Brozewicz Kamil , Slawinski Jaroslaw 
Published: August 2013

AbstractA series of novel 1‐(2‐mercaptobenzenesulfonyl)‐3‐hydroxyguanidines like (VIII) or (XII) is synthesized and evaluated for their in vitro anticancer activity.
ChemInform Abstract: Intermolecular Gold‐Catalyzed Diastereo‐ and Enantioselective [2 + 2 + 3] Cycloadditions of 1,6‐Enynes with Nitrones.
Authors: Gawade Sagar Ashok , Bhunia Sabyasachi , Liu Rai‐Shung 
Published: August 2013

AbstractRacemic and enantioenriched polycyclic compounds are constructed from benzoid and nonbenzoid 1,6‐enynes and nitrones.
ChemInform Abstract: Highly Regio‐ and Stereoselective Hydrophosphinylation of Acetylenes with Diphenylphosphine Oxide Catalyzed by Immobilization of Rhodium in MCM‐41.
Authors: Huang Yixiang , Hao Wenyan , Ding Guodong , Cai Ming‐Zhong 
Published: August 2013

AbstractA variety of (E)‐alkenylphosphine oxides are obtained in good to excellent yields in the presence of immobilized rhodium catalyst MSR.
ChemInform Abstract: Catalyst‐ and Solvent‐Free, Ultrasound‐Promoted Rapid Protocol for the One‐Pot Synthesis of α‐Aminophosphonates at Room Temperature.
Authors: Dar Bashir , Singh Amrinder , Sahu Akshya , Patidar Praveen , Chakraborty Arup , Sharma Meena , Singh Baldev 
Published: August 2013

AbstractThe simple three‐component process allows an access to various title compounds as analogues of amino acids in good to excellent yields.
ChemInform Abstract: Three New Resin Glycosides and a New Tetrahydropyran Derivative from the Seeds of Quamoclit pennata.
Authors: Ono Masateru , Takaki Yoshinari , Takatsuji Masamitsu , Akiyama Kousuke , Okawa Masafumi , Kinjo Junei , Miyashita Hiroyuki , Yoshimitsu Hitoshi , Nohara Toshihiro 
Published: August 2013

Abstract[isolation and structure determination of four new resin glycosides quamoclins V—VII [cf.
ChemInform Abstract: New High‐Temperature Pb‐Catalyzed Synthesis of Inorganic Nanotubes.
Authors: Brontvein Olga , Stroppa Daniel G. , Popovitz‐Biro Ronit , Albu‐Yaron Ana , Levy Moshe , Feuerman Daniel , Houben Lothar , Tenne Reshef , Gordon Jeffrey M. 
Published: August 2013

AbstractMoS2, MoSe2, WS2, and WSe2 nanotubes are prepared by irradiation of 1:1 molar mixtures of MoS2, MoSe2, WS2, or WSe2 and Pb/PbO with highly concentrated solar beam radiation and exposure times of 30—1200 s.
ChemInform Abstract: An Environmentally Friendly Method for the Synthesis of Nano‐Alumina with Controllable Morphologies.
Authors: Liu Chengchao , Li Jinlin , Liew Kongyong , Zhu Junjiang , bin Nordin Mohd Ridzuan 
Published: August 2013

AbstractAlumina nanostructures are prepared by dropwise addition of an aqueous (NH4)2CO3 solution to Al(NO3)3 dissolved in EtOH (1.
ChemInform Abstract: Identification of (R)‐N‐(4‐(4‐Methoxyphenyl)thiazol‐2‐yl) ‐1‐tosylpiperidine‐2‐carboxamide, ML277, as a Novel, Potent and Selective Kv7.1 (KCNQ1) Potassium Channel Activator.
Authors: Hopkins Corey R. , et al. et al. 
Published: August 2013

AbstractCompound (I) is identified as a potent activator of KCNQ1 channels using a high‐throughput screen of the NIH Molecular Library Small Molecule Repository.
Design and Synthesis of Fluoroacylshikonin as an Anticancer Agent
Authors: Kong Wen‐Yao , Chen Xiao‐Feng , Shi Jing , Baloch Shahla Karim , Qi Jin‐Liang , Zhu Hai‐Liang , Wang Xiao‐Ming , Yang Yong‐Hua 
Published: August 2013

ABSTRACTA series of shikonin derivatives, selectively acylated by various fluorinated carboxylic acids at the side chain of shikonin, were synthesized and their anticancer activity evaluated, in which eight compounds are reported for the first time. Among all the compounds tested, compound S7 showed the most potent anticancer activity against B16‐F10 (malignant melanoma cells), MG63 (human osteosarcoma cells), and A549 (lung cancer cells) with IC50 0.39 ± 0.01, 0.72 ± 0.04 and 0.58 ± 0.02 µmol/L. Docking simulation of compound S7 was carried out to position S7 into a tubulin active site to determine the probable binding conformation. All the results suggested that compound S7 may be a potential anticancer agent. Chirality 25:757–762, 2013. © 2013 Wiley Periodicals, Inc.
Nonconsumptive effects in a multiple predator system reduce the foraging efficiency of a keystone predator
Authors: Davenport Jon M. , Chalcraft David R. 
Published: August 2013

AbstractMany studies have demonstrated that the nonconsumptive effect (NCE) of predators on prey traits can alter prey demographics in ways that are just as strong as the consumptive effect (CE) of predators. Less well studied, however, is how the CE and NCE of multiple predator species can interact to influence the combined effect of multiple predators on prey mortality. We examined the extent to which the NCE of one predator altered the CE of another predator on a shared prey and evaluated whether we can better predict the combined impact of multiple predators on prey when accounting for this influence. We conducted a set of experiments with larval dragonflies, adult newts (a known keystone predator), and their tadpole prey. We quantified the CE and NCE of each predator, the extent to which NCEs from one predator alters the CE of the second predator, and the combined effect of both predators on prey mortality. We then compared the combined effect of both predators on prey mortality to four predictive models. Dragonflies caused more tadpoles to hide under leaf litter (a NCE), where newts spend less time foraging, which reduced the foraging success (CE) of newts. Newts altered tadpole behavior but not in a way that altered the foraging success of dragonflies. Our study suggests that we can better predict the combined effect of multiple predators on prey when we incorporate the influence of interactions between the CE and NCE of multiple predators into a predictive model. In our case, the threat of predation to prey by one predator reduced the foraging efficiency of a keystone predator. Consequently, the ability of a predator to fill a keystone role could be compromised by the presence of other predators.
Speciation patterns and processes in the zooplankton of the ancient lakes of Sulawesi Island, Indonesia
Authors: Vaillant James J. , Bock Dan G. , Haffner G. Douglas , Cristescu Melania E. 
Published: August 2013

AbstractAlthough studies of ancient lake fauna have provided important insights about speciation patterns and processes of organisms in heterogeneous benthic environments, evolutionary forces responsible for speciation in the relatively homogenous planktonic environment remain largely unexplored. In this study, we investigate possible mechanisms of speciation in zooplankton using the freshwater diaptomids of the ancient lakes of Sulawesi, Indonesia, as a model system. We integrate phylogenetic and population genetic analyses of mitochondrial and nuclear genes with morphological and genome size data. Overall, our results support the conclusion that colonization order and local adaptation are dominant at the large, island scale, whereas at local and intralacustrine scales, speciation processes are regulated by gene flow among genetically differentiated and locally adapted populations. In the Malili lakes, the diaptomid populations are homogenous at nuclear loci, but show two highly divergent mitochondrial clades that are geographically restricted to single lakes despite the interconnectivity of the lake systems. Our study, based on coalescent simulations and population genetic analyses, indicates that unidirectional hybridization allows gene flow across the nuclear genome, but prevents the introgression of mitochondria into downstream populations. We suggest that hybridization and introgression between young lineages is a significant evolutionary force in freshwater plankton.
Synthesis of Structurally Diverse Polyfunctional Pyrrolo[1,2‐a]quinolines by Sequential Iron‐Catalyzed Three‐Component Coupling and Gold‐Catalyzed Hydroarylation Reactions
Authors: Sarkar Soumen , Bera Krishnendu , Jalal Swapnadeep , Jana Umasish 
Published: August 2013

AbstractA simple and efficient synthesis of complex pyrrolo[1,2‐a]quinoline derivatives was achieved through sequential reactions that involved an iron(III)‐catalyzed synthesis of N‐(2‐alkynylaryl)pyrroles and a gold(III)‐catalyzed intramolecular hydroarylation reaction. This strategy tolerated a wide range of substrates with a variety of sensitive functional groups and afforded the corresponding pyrrolo[1,2‐a]quinoline derivatives in moderate to good yields. The ease of availability of the starting materials and the generality of the reaction sequences make it a highly attractive strategy to synthesize a diverse range of pyrrolo[1,2‐a]quinoline derivatives. Moreover, a preliminary photophysical study showed that the resulting molecules exhibit good fluorescence activity.
Aerodynamics, climate and ventilation in long rail tunnels considering an Andean base tunnel between Argentina and Chile / Aerodynamik, Klimatisierung und Belüftung von langen Eisenbahntunneln am Beispiel eines Basistunnels in den Anden zwischen Argentinien und Chile
Authors: Flueckiger Michael , Reinke Peter 
Published: August 2013

AbstractFor rail tunnels which are long, heavily used and intended for high‐speed traffic, the aspects of aerodynamics, climate and ventilation may require particular design solutions. Pressure fluctuations require measures at the structures, the tunnel equipment and the rolling stock. Acceptable climate conditions are required despite heat input from the ground, rolling stock and/or technical equipment. The design of the mechanical tunnel ventilation system (TVS) is influenced by the geothermal and topographical boundary conditions as well as the occupational health and the safety requirements among other factors. In turn, the TVS influences the structural layout of the tunnel. The example of the Base Tunnel (BT) on the project Corredor Bioceanico Aconcagua (CBA) is intended to illustrate the importance of some of these aspects in a tunnelling project. The CBA is a planned rail link between Chile and Argentina with a length of about 215 km. An important component of the CBA project is a 53 km long BT (CBA‐BT) which allows the most direct crossing of the Andes with moderate gradients. The BT is the subject of on‐going conceptual studies.Bei langen, stark genutzten und für Hochgeschwindigkeitsverkehr vorgesehenen Eisenbahntunneln erfordern Gesichtspunkte der Aerodynamik, des Tunnelklimas und der Belüftung besondere Entwurfslösungen. Druckschwankungen erfordern Maßnahmen an Bauteilen, der Tunnelausrüstung und an den Zügen. Trotz des Wärmeeintrags aus dem Gebirge, den Zügen und/oder der technischen Ausrüstung müssen annehmbare klimatische Bedingungen gewährleistet werden. Die Planung der mechanischen Tunnelbelüftungsanlage (TVS) wird von den geothermischen und topografischen Randbedingungen beeinflusst, ebenso wie von Arbeitsschutz‐ und Sicherheitsanforderungen, usw. Die Belüftungsanlage wiederum hat einen Einfluss auf die bautechnische Planung des Tunnels. Am Beispiel des Basistunnels (BT) des Projekts Corredor Bioceanico Aconcagua (CBA) soll die Bedeutung einiger dieser Aspekte in einem Tunnelprojekt aufgezeigt werden. Die CBA ist eine geplante Bahnstrecke zwischen Chile und Argentinien mit einer Länge von etwa 215 km. Ein wichtiger Bestandteil des CBA‐Projekts ist ein 53 km langer Basistunnel (CBA‐BT), der eine direkte Querung der Anden mit geringen Steigungen ermöglicht. Der Basistunnel ist Gegenstand der laufenden Konzeptstudien.