bluuebunny/crossref_metadata_2025_split huggingface dataset:
Imaging endpoints to predict response to IGF1R/IR inhibition in CRC models
Authors: Serkova Natalie J. , Bradshaw-Pierce Erica L. , Hasebroock Kendra M. , Merz Andrea L. , Pitts Todd M. , Eckhardt Gail S. 
Published: May 2015

Abstract
Colorectal cancer (CRC) represents a major health burden and accounts for nearly 10% of all cancer-related deaths in the U.S. Among the many new pathways being exploited for cancer treatment is the insulin-like growth factor receptor (IGF1R) signaling pathway, which appears to be a robust target in CRC (e.g., hyperactivated in more than 50% of CRC patients). OSI-906 is a novel selective dual inhibitor IGF-1R and IR kinase activities. Despite advances in molecular predictive markers, a substantial proportion of patients selected for targeted therapy has nonresponsive tumors and require additional combination-based regimens. Unlike cytotoxic chemotherapeutic agents, most novel signal transduction modulators (STMs) induce only modest tumor regression, thus there is significant need for establishing functional pharmacodynamic (e.g., therapy response) endpoints for inhibition of signaling via particular pathways. In the present study we established noninvasive imaging-based endpoints for response to OSI-906 in CRC mouse models. Female nude mice were implanted with either of two human CRC cell lines (one sensitive and one resistant) or individual human surgical CRC explants (with unknown sensitivity). Metabolic changes (decreased glucose uptake and lactate production by FDG-PET and proton MRS, respectively) were apparent in OSI-906-sensitive xenografts as early as 2 days post-treatment when no changes in tumor size were yet detected. A significant decrease in tumor size and membrane choline-containing phospholipids by MRI and MRS, respectively, were seen after 27 days of treatment in OSI-906-sensitive xenografts. No changes in FDG-PET, MRS, or tumor progression were observed in OSI-906 resistant xenografts. Our data indicate that noninvasive functional imaging endpoints can provide early and sensitive markers for cytostatic action of IGF1R/IR inhibitors.
This talk is also presented as Poster A14.
On the identity of Basigona lucasii Silvestri, 1896, a poorly known millipede from Tunisia, with notes on the North African Chordeumatida (Diplopoda: Chordeumatida: Chamaesomatidae)
Authors: AKKARI NESRINE , ENGHOFF HENRIK , STOEV PAVEL , MAURIÈS JEAN-PAUL 
Published: May 2015

Considering the very high diversity of Chordeumatida in Europe, namely almost 500 described species in 140 genera (Enghoff & Kime 2009), the paucity of records of this order in North Africa is striking. The order has hitherto been reported only from Morocco, Algeria and Tunisia.
A new species Micrarctia kautti (Lepidoptera: Erebidae, Arctiinae) from West China
Authors: Saldaitis Aidas , PEKARSKY OLEG 
Published: May 2015

A new tiger moth, Micrarctia kautti sp. n., from southwest China, Sichuan is described. A diagnostic comparison with Micrarctia trigona (Leech, 1899) is provided. During recent years the Chinese Arctiini have been intensively collected and explored (Dubatolov, 1996a; Dubatolov, 1996b; Dubatolov, 2003; Dubatolov, Kishida & Wu, 2005; Fang & Cao, 1984; Fang, 2000 and numerous other publications) so the discovery of a striking new species by Sergey Murzin in the Dafengding Mountains, Sichuan Province, was most unexpected. Institutional acronyms used are as follows: ASV = Aidas Saldaitis (Vilnius, Lithuania); KNE = Kari Nupponen (Espoo, Finland); PKT = Peter Kautt (Tübingen, Germany); RMB = Ramon Macià (Barselona, Spain); WIGJ = World Insect Gallery (Joniškis, Lithuania).
NOAA’s HYSPLIT Atmospheric Transport and Dispersion Modeling System
Authors: Stein A. F. , Draxler R. R. , Rolph G. D. , Stunder B. J. B. , Cohen M. D. , Ngan F. 
Published: May 2015

Abstract
The Hybrid Single-Particle Lagrangian Integrated Trajectory model (HYSPLIT), developed by NOAA’s Air Resources Laboratory, is one of the most widely used models for atmospheric trajectory and dispersion calculations. We present the model’s historical evolution over the last 30 years from simple hand-drawn back trajectories to very sophisticated computations of transport, mixing, chemical transformation, and deposition of pollutants and hazardous materials. We highlight recent applications of the HYSPLIT modeling system, including the simulation of atmospheric tracer release experiments, radionuclides, smoke originated from wild fires, volcanic ash, mercury, and wind-blown dust.
Recent Changes in Annual Area Burned in Interior Alaska: The Impact of Fire Management
Authors: Calef M. P. , Varvak A. , McGuire A. D. , Chapin F. S. , Reinhold K. B. 
Published: May 2015

Abstract
The Alaskan boreal forest is characterized by frequent extensive wildfires whose spatial extent has been mapped for the past 70 years. Simple predictions based on this record indicate that area burned will increase as a response to climate warming in Alaska. However, two additional factors have affected the area burned in this time record: the Pacific decadal oscillation (PDO) switched from cool and moist to warm and dry in the late 1970s and the Alaska Fire Service instituted a fire suppression policy in the late 1980s. In this paper a geographic information system (GIS) is used in combination with statistical analyses to reevaluate the changes in area burned through time in Alaska considering both the influence of the PDO and fire management. The authors found that the area burned has increased since the PDO switch and that fire management drastically decreased the area burned in highly suppressed zones. However, the temporal analysis of this study shows that the area burned is increasing more rapidly in suppressed zones than in the unsuppressed zone since the late 1980s. These results indicate that fire policies as well as regional climate patterns are important as large-scale controls on fires over time and across the Alaskan boreal forest.
Climate Variability and the U.S. Corn Belt: ENSO and AO Episode-Dependent Hydroclimatic Feedbacks to Corn Production at Regional and Local Scales*
Authors: Kellner Olivia , Niyogi Dev 
Published: May 2015

Abstract
El Niño–Southern Oscillation (ENSO) and Arctic Oscillation (AO) climatology (1980–2010) is developed and analyzed across the U.S. Corn Belt using state climate division weather and historic corn yield data using analysis of variance (ANOVA) and correlation analysis. Findings provide insight to agroclimatic conditions under different ENSO and AO episodes and are analyzed with a perspective for potential impacts to agricultural production and planning, with findings being developed into a web-based tool for the U.S. Corn Belt.
This study is unique in that it utilizes the oceanic Niño index and explores two teleconnection patterns that influence weather across different spatiotemporal scales. It is found that the AO has a more frequent weak to moderate correlation to historic yields than ENSO when correlated by average subgrowing season index values. Yield anomaly and ENSO and AO episode analysis affirms the overall positive impact of El Niño events on yields compared to La Niña events, with neutral ENSO events in between as found in previous studies. Yields when binned by the AO episode present more uncertainty. While significant temperature and precipitation impacts from ENSO and AO are felt outside of the primary growing season, correlation between threshold variables of episode-specific temperature and precipitation and historic yields suggests that relationships between ENSO and AO and yield are present during specific months of the growing season, particularly August. Overall, spatial climatic variability resulting from ENSO and AO episodes contributes to yield potential at regional to subregional scales, making generalization of impacts difficult and highlighting a continued need for finescale resolution analysis of ENSO and AO signal impacts on corn production.
Subregion-Scale Hindcasting of Contrail Outbreaks, Utilizing Their Synoptic Climatology
Authors: Carleton Andrew M. , Silva Armand D. , Bernhardt Jase , VanderBerg Justin , Travis David J. 
Published: May 2015

AbstractContrail statistical prediction methods are often location specific. To take advantage of the fact that the upper-tropospheric (UT) meteorological conditions that favor “clear-sky outbreaks” of persisting contrails, or contrail favored areas (CFAs), tend to be synoptic in scale, a visual UT-map technique to hindcast CFAs has been developed and tested for subregions of the contiguous United States (CONUS) that have high outbreak frequencies in midseason months (January, April, July, and October) of 2000–02. The method compares daily maps with the composite fields for outbreak days (CON) versus nonoutbreak days (NON), and those assessments are evaluated using standard skill measures. Binary logistic regression determines which UT variables are significant predictors, individually and in combination. The reproducibility of the outbreak hindcast results is tested on the same subregions for the corresponding months of 2008–09. The results confirm the importance of UT relative humidity and vertical-motion (omega) map patterns in regional clear-sky outbreaks. Although the hindcast skill is modest, sensitivity tests suggest that the method will be substantially improved when a longer-term climatological dataset of outbreaks becomes available (to increase sample sizes) and with explicit consideration of the synoptic types on CON days. The latter is demonstrated specifically for the southern CONUS in January, where to improve hindcast success one should also consider the vertical wind shear in the upper troposphere, given the importance of the subtropical jet stream in contrail outbreaks there. Further development of the method to improve its skill ultimately should permit its use in combination with existing objective (statistical and physical models) methods of contrail prediction.
On Conditions for Unrectifiability of a Metric
Space
Authors: Hajłasz Piotr , Malekzadeh Soheil 
Published: May 2015

Abstract
We find necessary and sufficient conditions for a Lipschitz map f : E ⊂ ℝk → X into a metric space
to satisfy ℋk(f(E)) = 0. An interesting feature of our approach is that despite the fact that we are dealing with
arbitrary metric spaces, we employ a variant of the classical implicit function theorem. Applications include
pure unrectifiability of the Heisenberg groups.
Inverse Limit Spaces Satisfying a Poincaré Inequality
Authors: Cheeger Jeff , Kleiner Bruce 
Published: May 2015

Abstract
We give conditions on Gromov-Hausdorff convergent inverse systems of metric measure graphs
which imply that the measured Gromov-Hausdorff limit (equivalently, the inverse limit) is a PI space i.e., it
satisfies a doubling condition and a Poincaré inequality in the sense of Heinonen-Koskela [12]. The Poincaré
inequality is actually of type (1, 1). We also give a systematic construction of examples for which our conditions
are satisfied. Included are known examples of PI spaces, such as Laakso spaces, and a large class of new
examples. As follows easily from [4], generically our examples have the property that they do not bilipschitz
embed in any Banach space with Radon-Nikodym property. For Laakso spaces, thiswas noted in [4]. However
according to [7] these spaces admit a bilipschitz embedding in L1. For Laakso spaces, this was announced
in [5].
Some Results on Maps That Factor through a Tree
Authors: Züst Roger 
Published: May 2015

Abstract
We give a necessary and sufficient condition for a map deffned on a simply-connected quasi-convex
metric space to factor through a tree. In case the target is the Euclidean plane and the map is Hölder continuous
with exponent bigger than 1/2, such maps can be characterized by the vanishing of some integrals
over winding number functions. This in particular shows that if the target is the Heisenberg group equipped
with the Carnot-Carathéodory metric and the Hölder exponent of the map is bigger than 2/3, the map factors
through a tree.
Locally n-Connected Compacta and UVn
-Maps
Authors: Valov V. 
Published: May 2015

Abstract
We provide a machinery for transferring some properties of metrizable ANR-spaces to metrizable
LCn-spaces. As a result, we show that for completely metrizable spaces the properties ALCn, LCn and
WLCn coincide to each other. We also provide the following spectral characterizations of ALCn and celllike
compacta: A compactum X is ALCn if and only if X is the limit space of a σ-complete inverse system S = {Xα , pβ
α , α < β < τ} consisting of compact metrizable LCn-spaces Xα such that all bonding projections
pβ
α, as a well all limit projections pα, are UVn-maps.
A compactum X is a cell-like (resp., UVn) space if and only if X is the limit space of a σ-complete inverse
system consisting of cell-like (resp., UVn) metrizable compacta.
Mathematical Model of Forecasting the Formation of Sinkhole Using Salustowicz’s Theory / Model Matematyczny Prognozowania Zapadlisk Przy Wykorzystaniu Teorii Sklepienia Ciśnień Sałustowicza
Authors: Strzałkowski Piotr 
Published: May 2015

Abstract
In area affected by old, shallow extraction in some cases sinkholes are formed, causing security issues in urbanized areas. Problem of working out deterministic forecast of this threat seems to be important and up-to-date. Mathematical model presented in this work let us predict the possibility of sinkhole formation. That prediction is essential for analyzing possibility of investments in such areas. Basing on presented work, it is also possible to determine dimensions of sinkhole. Considerations are based on known from literature Sałustowicz’s theory, which is utilises Huber’s solution of equation describing the stress state around elliptic void made in flat plate
Influence of the Plow Filling and Thread Angle onto the Plow Head Efficiency / Wpływ Współczynnika Wypełnienia Organu Oraz Kąta Nawinięcia Płata Ślimaka Na Sprawność Ładowania Frezującymi Organami Ślimakowymi
Authors: Wydro Tomasz 
Published: May 2015

Abstract
Laboratory examinations on the plow heads at various filling rate and material grain-size, as well as various values of worm thread angle of the plow head have been executed. Influence of the worm thread angle and plow head filling onto optimal loading efficiency, has also been tested.
Rare Earth Elements of Orzeskie Beds of South-West Part Upper Silesian Coal Basin (Poland) / Pierwiastki Ziem Rzadkich Z Pokładów Węgla Warstw Orzeskich Południowo-Zachodniej Części Gzw (Polska)
Authors: Adamczyk Zdzisław , Białecka Barbara , Moszko Joanna Całusz , Komorek Joanna , Lewandowska Małgorzata 
Published: May 2015

Abstract
The subject of the research concerned the coal samples from 360/1, 361 and 362/1 seams of the Orzesze beds in the “Pniówek” coal mine. The obtained samples were characterized by low ash content - 2.22- 6.27% of the mass. The chemical composition of the ash indicates the presence of aluminosilicate minerals in the analyzed coal samples - most likely clay minerals, the presence of which has been confirmed in microscopic tests of the petrographic composition of channel samples of coal.
The content of rare earth elements (REE sum) in the ash of the tested coal seams ranged from 364 to 1429 ppm. Variation of the REE content has been observed within a single seam.
The fraction of REE indicates a relation with a mineral substance. No relation of the REE fraction and the presence of red beds has been found based on the tested samples.
The content of REE found in ash, normalized to chondrites, is characterized by LREE enrichment in relation to HREE. The Eu anomaly is most likely related to tuff and tonstein levels occurring in Orzesze beds, which accompany the coal seams in the Upper Silesian Coal Basin (i.a., south of the studied area).
The research has indicated that LREE in the tested samples are more related to the mineral substance, while HREE have a stronger affinity with organic substances.
Simulation Based Investigation of Different Fleet Management Paradigms in Open Pit Mines-A Case Study of Sungun Copper Mine / Symulacje I Badania Różnych Paradygmatów Wykorzystania Floty Pojazdów I Urządzeń W Kopalniach Odkrywkowych. Studium Przypadku: Kopalnia Miedzi W Sungun
Authors: Hashemi Ali Saadatmand , Sattarvand Javad 
Published: May 2015

Abstract
Using simulation modeling, different management systems of the open pit mining equipment including non-dispatching, dispatching and blending solutions have been studied for the Sungun copper mine. Developed model has the capability of considering detailed features of both loading and hauling equipment. Productivity assessment scenarios have been established on the constructed model and the outputs revealed the noteworthy impact of the match factor of the trucks to the loaders on the production rate by over 40%. A dispatching simulation model with the objective function of minimizing truck waiting times have been developed and 7.8% improvement obtained by applying a flexible assignment of the trucks for the loaders compared to the fixed assignment system. Finally ore grade blending control unit has been introduced into the model. Getting the advantages of the newly added module it became possible to monitor the portion of material excavated from different operating benches and control truck dispatching rules for keeping the overall ore grade exactly at desired value.
Liquefied Natural Gas Storage of Variable Composition / Magazynowanie Skroplonego Gazu Ziemnego O Zmiennym Składzie
Authors: Łaciak Mariusz 
Published: May 2015

Abstract
Thanks to the increasing diversification of LNG supply sources, being a result of the growing number of LNG liquefaction installations over the World, increase of short-term trade contracts and general trend to globally liberalize gas markets, reception terminals have to cope with the broad range of qualitatively diversified LNG deliveries from various sources. Different LNG deliveries potentially have different density caused by different gas composition. Although the LNG composition depends on LNG source, it mainly consists of methane, ethane, propane, butane and trace nitrogen. When a new supply of LNG is transported to the tank, the LNG composition and temperature in the tank can be different from LNG as delivered. This may lead to the liquid stratification in the tank, and consequently the rollover. As a result, LNG rapidly evaporates and the pressure in the tank increases. More and more restrictive safety regulations require fuller understanding of the formation and evolution of layers. The paper is focused on the analysis of liquid stratification in the tank which may take place when storing LNG, and which process leads to the rapid evaporation of considerable quantities of LNG. The aim was to attempt modeling of the process of liquid stratification in an LNG tank. The paper is closed with the results of modelling.
Comments on “Determination and Analysis of the Theoretical Production of a Bucket Wheel Excavator” / Uwagi I Komentarze Do Pracy: ”Określanie I Analiza Teoretycznej Wydajności Pracy Koparki Wielonaczyniowej Kołowej”
Authors: Bošnjak Srđan M. 
Published: May 2015

Abstract
This paper comments on the recently published work dealing with the problem in the determination of the theoretical output of the bucket wheel excavator. It also includes remarks on the inadequacy in the problem approach and highlights the mistakes in the mathematical model. This work emphasizes the demand for a much wider and deeper approach to the problem of determining the output of the bucket wheel excavator.
Stability Assessment of the High Safety Pillars in Slovenian Natural Stone Mines / Ocena Stabilności Wysokich Filarów Bezpieczeństwa W Kopalniach Kamieni Naturalnych W Słowenii
Authors: Kortnik Jože 
Published: May 2015

Abstract
For the first time in Slovenia, the underground excavation of natural stone blocks was introduced on a trial basis at the Hotavlje I colourful limestone quarry in 1993, in 2002 at the Lipica II limestone quarry, in 2008 at the Lipica I limestone quarry and in 2009 also at the Doline limestone quarry. This was primarily because of the geological structure of the site, the quarry’s condition, the potentially large amounts of the overburden in the event of an expansion of the surface part of the quarry, and the increasing needs for this raw material, i.e. natural stone.
The underground excavation of natural stone in all locations are done using a modified room-and-pillar excavation method that is adjusted to each site’s characteristics, with regularly or irregularly distributed high safety pillars. Since the underground excavation of natural stone blocks is performed at a relatively shallow level under the surface, i.e., at a depth of only 10-40 m, the value of the primary vertical stress state is also relatively low (less than 1.0 MPa).
This significantly increases the risk of wedge-shaped pieces or blocks falling out of the ceiling in open underground spaces. In previous years, special attention was paid to the installation of stress-strain systems for controlling the planned dimensions (width and height) of large, open, underground spaces (rooms) and the dimensions of the high safety pillars, along with continual monitoring and identification of the instability phenomena in the ceiling and sides of the large open spaces (rooms).
The paper presents the methods and devices used for the optimization and the safety monitoring of high safety pillars for the underground excavation of natural stone blocks in Slovenian natural stone mines.
Participation of Quaternary Aquifers in Groundwater Inflow to Mines in the Upper Silesian Coal Basin (USCB) / Udział Wodonośnych Utworów Czwartorzędowych W Procesie Zawodnienia Kopalń Górnośląskich
Authors: Różkowski Kazimierz , Różkowski Andrzej , Sołtysiak Marek 
Published: May 2015

Abstract
The Upper Silesian Coal Basin (USCB) is situated within Variscean depression in the southern Poland. Mining of the hard coal, ore and sand deposits in the USCB has a long-lasting tradition. Exploitation has been carried out with both - open pit and mainly underground operations. The intensity of water inflows to mines depends on geogenic and technological factors. Among geogenic factors the main one is occurrence of thick water - bearing Quaternary sediments in the roof of Carboniferous ore deposits. Among technological factors the essential influence on the inflows to the mine workings have: time, depth and surface of exploitation, as well as drainage intensity.
Bibliotheken und der demografische Wandel
Authors: Kulzer Gudrun 
Published: May 2015

Zusammenfassung:
Aufgrund der demographischen Entwicklung nimmt der Anteil der älteren Menschen an der deutschen Gesamtbevölkerung zu. Daher gewinnt diese Bevölkerungsgruppe immer mehr an Bedeutung und es wird immer wichtiger, sich mit dieser Zielgruppe auseinanderzusetzen. Die Angebote, die Bibliotheken für die Zielgruppe der Älteren entwickeln können, hängen von den jeweiligen örtlichen Voraussetzungen und den Möglichkeiten der Bibliothek (Personal, Budget, Räumlichkeiten) ab. Bei den Älteren handelt es sich um eine heterogene Gruppe, die mehrere Generationen umfasst, und deren Migtglieder unterschiedliche Bildungsabschlüsse und Interessen haben. Darüber hinaus unterscheidet sie sich im geistigen und körperlichen Zustand ebenfalls sehr stark. Die Bibliothek sollte das Spektrum des Angebots in einem Konzept mit klarer Zielsetzung entwickeln, damit es erfolgreich ist.
Make the library
really
look more like google
Authors: Bartlakowski Katja 
Published: May 2015

Zusammenfassung:
Immer noch ist es Wunsch und Überzeugung vieler Bibliotheken, dass ihr Internetauftritt als zentrale Anlaufstelle für Informationssuchende wahrgenommen wird. In der Realität hingegen spielt der Wert der Bibliothekswebsite für Studierende und Lehrende eine zunehmend untergeordnete Rolle. Die Einführung eines Discovery-Systems bietet in diesem Zusammenhang gute Möglichkeiten, das überholte Portalkonzept bibliothekarischer Internetseiten zu überdenken und neue Wege zu gehen.