bluuebunny/crossref_metadata_2025_split huggingface dataset:
Innovation through Experience Staging: Motives and Outcomes
Authors: Candi Marina , Beltagui Ahmad , Riedel Johann C. K. H. 
Published: October 2012

There is a growing recognition of the opportunities of innovation through experience staging. The literature, however, tends to focus on high‐profile examples of firms from largely hedonic sectors, such as entertainment and hospitality. These cases provide vivid and persuasive examples, but they fail to address how firms outside these sectors can join the experience economy—a term coined in 1998 by Pine and Gilmore—by developing new products and services with experiences at their core. The paper reports on two studies undertaken to examine why firms that do not belong to sectors that are largely hedonic innovate through experience staging and how they benefit from doing so. The first study is an in‐depth case study of 15 diverse firms, which examines these firms' motives for pursuing innovation through experience staging. The second study is a two‐year longitudinal quantitative survey of 131 small‐ and medium‐sized firms (SMEs) to address the question of the benefits that firms that do not have strong brands can gain by from innovation through staging experiences.The first study provides the basis for classifying firms along two dimensions depending on the nature of the new products or services (referred to collectively as offerings) they create. The first dimension has to do with whether new offerings have a functional or experiential core. The second dimension has to do with the degree of experiential augmentation applied to offerings.The first study suggests that firms adopt an experience‐staging strategy to innovation based on both outward‐facing and inward‐facing motives. The outward‐facing motives include improving a firm's image in its market, entering new markets, and attracting new customers. The inward‐facing motives include improving a firm's attractiveness to employees and increasing profitability. The results of the second study suggest that creating offerings with an experiential core can contribute to success by enhancing a firm's image, its attractiveness to employees, and its ability to enter new markets. Moreover, experiential augmentation contributes to profitability, new customer attraction, and employee attractiveness.This research has important implications for theory and practice. In the first place, this research extends existing theory about experience staging to firms outside sectors that are largely hedonic. In the second place, the managerial implications are that innovation through experience staging can be an effective way for SMEs, even those outside industries, such as entertainment or hospitality, to create competitive advantage.
Effect of ethnicity on erythropoietin therapy response for hemodialysis patients: A retrospective study
Authors: Al‐khalaf Bader , Al‐khalaf Nour , Mustafa Seham 
Published: October 2012

AbstractAnemia is a common feature in chronic kidney disease patients due to deficiency of erythropoietin (EPO). Diseased kidneys are unable to produce EPO, which enhances red blood cell production from the bone marrow. Recombinant human EPO in hemodialysis patients was introduced with perfect outcomes as a hormonal substitutive treatment. Some ethnic minority groups have high prevalence of anemia associated with chronic kidney diseases. The aim of this study is to evaluate the differences between African Caribbeans and Caucasians’ EPO therapy response with regard to hemoglobin (Hb), some factors affecting it and some comorbid conditions. A retrospective study for 6 months of 100 patients on hemodialysis was conducted on two ethnic minorities groups; 46 patients were African Caribbean and 54 patients were Caucasian, who received EPO therapy at once or three times weekly dose at the Hanbury Dialysis Unit of Royal London Hospital. There were three types of EPO therapy used: Aranesp, Mircera and Neorecormon. Forty‐six patients were African Caribbean and 54 patients were Caucasian. There were 63.4% of patients treated by Aranesp while 13% were given Mircera; 22.8% of the sample used Neorecorman. It was shown that the chosen comorbid conditions had higher percentage in the African Caribbeans than in Caucasians. Diabetic and/or hypertensive patients are almost double the patient numbers. In addition, sickle cell anemia is only present in African Caribbeans. There were 43.5% of African Caribbeans and 81.1% of Caucasians who met the standards of Hb level. There was no significant difference between African Caribbeans and Caucasians regarding parathyroid hormone, c‐reactive protein, B12, mean corpuscular volume, ferritin, and folate. In this study, there was a significant difference in the Hb levels between African Caribbean and Caucasian groups. Sixty percent of African Caribbeans had mean Hb less than normal levels. However, they received lower EPO dose than Caucasians. As a result, this may affect the whole treatment and therapy which may lead to anemic complications.
Cross‐evaluation of facial hyperpigmented lesions based on fluorescence color image and cross‐polarized color image
Authors: Kim Eunji , Kim Dongyoun , Choi Eung H. , Jung Byungjo 
Published: October 2012

Background/purposeHyperpigmentation is a common skin problem that looks darker than normal skin regions. Accurate evaluation of a hyperpigmented lesion (HPL) is of clinical importance because proper choice of treatment can be dependent on it. This study aimed to differentiate between epidermal and dermal HPLs.MethodsCross‐polarized color images (CPCIs) and fluorescence color images (FCIs) were acquired from the same facial regions. Contrast‐limited adaptive histogram equalization (CLAHE) was employed to enhance the image contrast and a fuzzy c‐means algorithm was implemented to extract the HPLs. The HPLs were superimposed to investigate the difference between CPCI and FCI.ResultsThe HPL was successfully extracted by applying both CLAHE and fuzzy c‐means algorithms. CPCI and FCI resulted in a slightly different HPL, even from the same facial region, indicating a greater percentage area of HPL in FCI than CPCI.ConclusionCPCI and FCI may be utilized to differentiate HPLs that exist in different skin layers. Thus, this approach may contribute to the effective treatment of HPLs.
Supporting housing and neighbourhoods for healthy ageing: Findings from the Housing and Independent Living Study (HAIL)
Authors: Byles Julie E , Mackenzie Lynette , Redman Sally , Parkinson Lynne , Leigh Lucy , Curryer Cassie 
Published: October 2012

AimTo identify the extent to which homes and neighbourhoods of older community‐dwelling people are ‘supportive’.MethodCross‐sectional survey, in‐home observation and interviews involving 202 participants (75–79 years). Measures included SF‐36 health‐related quality of life and Late Life Function and Disability Instrument (LLFDI) scores, and self‐reported home usability, access, safety and neighbourhood. Associations between home and neighbourhood characteristics were assessed using χ2‐tests, t‐tests and Pearson correlations.ResultsOlder people rated neighbourhood satisfaction highly (3.0 men, 3.2 women; 4 being the highest score). Many homes failed objective adaptability and safety ratings, particularly bathrooms (80% did not have a shower grab rail, 77% did not have non‐slip floors); 27% of homes scored ≥8 of 25 possible hazards. There were significant correlations between perceptions of housing and neighbourhood and SF‐36 and disability scores.ConclusionMany homes and neighbourhoods may not accommodate increased frailty or disability of older people into the future.
Measuring the Performance of Critical Access Hospitals in Missouri Using Data Envelopment Analysis
Authors: Gautam Shriniwas , Hicks Lanis , Johnson Thomas , Mishra Bhawani 
Published: October 2012

AbstractPurpose: Rural hospitals are critical for access to health care, and for their contributions to local economies. However, many rural hospitals, especially critical access hospitals (CAHs) need to strive for more efficiency for continued viability. Routinely evaluating their performance, and providing feedback to management and policy makers, is therefore important.Method: Three measures of relative efficiency are estimated for CAHs in Missouri using an Input‐oriented Data Envelopment Analysis with a variable returns to scale assumption and compared with the efficiency of other rural hospitals in Missouri using Banker's F‐test. Using 30‐day readmission rate as a measure of quality, CAHs are evaluated against efficiency‐quality dimensions.Findings: CAHs in Missouri had a slight decline in average technical efficiency, but they had a slight gain in average cost efficiency in 2009 compared to 2006. More than half of the CAHs were neither economically nor technically efficient in both years. The relative efficiency of other rural hospitals was statistically higher than that of CAHs in Missouri.Conclusions: This study validates the finding of relative inefficiency of CAHs compared to other hospitals paid under the Prospective Payment System at a state level (Missouri). However, with considerable variation in socioeconomic as well as health care access indicators across states, a relative efficiency frontier may not be the only relevant indicator of value for the evaluation of the performance of CAHs. Access to health care and the impact on the local economy provided by these CAHs to the community are also critical indicators for more comprehensive performance evaluation.
Promoting Heart Health in Rural Women
Authors: Fahs Pamela Stewart , Pribulick Margaret , Williams Ishan Canty , James Gary D. , Rovynak Virginia , Seibold‐Simpson Susan M. 
Published: October 2012

AbstractPurposeTo compare 2 strategies, stage‐matched nursing and community intervention (SMN+CI) and community intervention (CI) alone in changing cardiovascular risk factors in up to 3 behavioral areas: diet, physical activity, and/or smoking among rural women.MethodsA 14‐month, multisite randomized controlled trial of 117 rural women was conducted. Transtheoretical model was used in identification of stage of change and development of the SMN+CI nursing interventions. A social‐ecological model was used to address issues of rurality in the development of interventions.FindingsThe SMN + CI group was superior on 4 outcomes. There were significant increases in 2 measures of dietary intake; improvement in dietary stage of change for fruits and vegetables; and reduced diastolic blood pressure (DBP) in the SMN + CI group. After log transformation DBP significance was lost. The CI group had a significant reduction in change in total cholesterol; however, significance was lost after control for the initiation of lipid lowering medications. There was a significant reduction in Framingham risk scores pre‐ to postintervention, regardless of group.ConclusionsThere continues to be a need to improve cardiovascular risk factors in rural women. There should be an exploration of whether intensified dose and fidelity of the intervention strategies of diet and physical activity are effective in improving anthropometric and laboratory values. Further investigation is warranted into factors influencing the pre‐ to postreduction in Framingham risk scores.
A New Enantiornithine Bird from the Lower Cretaceous Jiufotang Formation in Jinzhou Area, Western Liaoning Province, China
Authors: Li LI , Jinqi WANG , Xi ZHANG , Shilin HOU 
Published: October 2012

AbstractA new Early Cretaceous enantiornithine bird from Liaoning Province of northeastern China, Shengjingornis yangi, gen. et sp. nov., is reported. This new bird possesses the following unique combination of features: a long rostrum, with some teeth in the front; short nasal; slender jugal; Y‐shaped furcula, with expanded distal end of the hypocleidum; cake‐like sternum, with a low and caudally distributed keel; strut‐like and caudally concave coracoid. The derived features of the scapula and the wings suggest a powerful flapping flight capability.
Geochemistry of Permian Mafic Igneous Rocks from the Napo‐Qinzhou Tectonic Belt in Southwest Guangxi, Southwest China: Implications for Arc‐Back Arc Basin Magmatic Evolution
Authors: Xiaofeng QIN , Zongqi WANG , Yingli ZHANG , Luozhong PAN , Guiang HU , Fusheng ZHOU 
Published: October 2012

AbstractThe Napo‐Qinzhou Tectonic Belt (NQTB) lies at the junction of the Yangtze, Cathaysia and Indochina (North Vietnam) Blocks, which is composed of five major lithotectonic subunits: the Qinzhou‐Fangcheng Suture Zone (QFSZ), the Shiwandashan Basin (SB), the Pingxiang‐Nanning Suture Zone (PNSZ), the Damingshan Block (DB) and the Babu‐Lingma Suture Zone (BLSZ). On the basis of geochemical compositions, the Permian mafic igneous rocks can be divided into three distinct groups: (1) mafic igneous rocks (Group 1) from the Longjing region in the PNSZ and Hurun region in the BLSZ, which are characterized by intermediate Ti, P and Zr with low Ni and Cr contents; (2) mafic igneous rocks (Group 2) from the Naxiao and Chongzuo region in the DB, characterized by low‐intermediate Ti, P and Zr with high Ni and Cr concentrations; and (3) mafic igneous rocks (Group 3) from the Siming region in the Jingxi carbonate platform of the northwestern margin of the NQTB, with intermediate‐high Ti, P and Zr and low Ni and Cr contents. The Group 1 rocks yield a weighted mean 206Pb/238U age of 250.5±2.8 Ma and are geochemically similar to basalts occurring in back‐arc basin settings. The Group 2 rocks exhibit geochemical features to those basalts in island arcs, whereas the Group 3 rocks show geochemical similarity to that of ocean island basalts. All three groups are characterized by relatively low εNd(t) values (–2.61 to +1.10) and high initial 87Sr/86Sr isotopic ratios (0.705309–0.707434), indicating that they were derived from a subduction‐modified lithospheric mantle and experienced assimilation, fractional crystallization, and crustal contamination or mixing during magmatic evolution. Accordingly, we propose the existence of an arc‐back arc basin system that developed along the NQTB at the border of SW Guangxi Province (SW China) and northern Vietnam, and it was formed by continued northwestward subduction of the Cathaysian (or Yunkai) Block under the Yangtze Block, and northeastward subduction of the Indochina Block beneath the Yangtze Block during Permian time.
LA‐ICP‐MS Zircon U‐Pb Dating of Intermediate‐Acidic Intrusive Rocks and Molybdenite Re‐Os Dating from the Bangpu Mo (Cu) Deposit, Tibet and its Geological Implication
Authors: Liqiang WANG , Yuchuan CHEN , Juxing TANG , Pengrui LÜ , Maocheng LUO , Huan WANG , Wei CHEN , Qiufeng LENG 
Published: October 2012

AbstractThe multi‐stage intrusions of intermediate‐acid magma occur in the Bangpu mining district, the petrogenic ages of which have been identified. The times and sequences of their emplacement have been collated and stipulated in detail in this paper by using the laser ablation‐inductively coupled plasma‐mass spectrometry (LA‐ICP‐MS) zircon U‐Pb dating method. The ages of biotite monzogranite that were formed before mineralization in the southwest of this mining district are 70±1 Ma (mean square of weighted deviates (MSWD) = 9.5, n= 8) and 60.60±0.31 Ma (MSWD=3.8, n= 16), which belong to the late Cretaceous–early Paleocene in age. That means, they are products of an early tectonic‐magmatic event of the collision between the Indian and Asian continentals. The ages of ore‐bearing monzogranite porphyry and ore‐bearing diorite porphyrite are 16.23±0.19 Ma (MSWD= 2.0, n= 26) and 15.16±0.09 Ma (MSWD=3.9, n= 5) separately, which belong to the middle Miocene in age; namely, they are products of the Gangdese post‐collision extensional stage when crust‐mantle materials melted and mixed as well as magmatic intrusion simultaneously occurred. Some zircons with ages of 203.6±2.2 Ma (MSWD=1.18, n= 7) were captured in the ore‐bearing diorite porphyrite, which shows that there had been tectono‐magmatic events in the late Triassic–early Jurassic. Molybdenum (copper) ore‐bodies produced in the monzogranite porphyry and copper (molybdenum) ore‐bodies produced in the diorite porphyrite are the main ore types in this ore deposit. The model ages of Re‐Os isotopic dating for the 11 molybdenite are 13.97–15.84 Ma, while isochron ages are 14.09±0.49 Ma (MSWD=26). The isochron ages of seven molybdenite from molybdenum (copper) ore with monzogranite porphyry type are 14.11±0.31 Ma (MSWD=5.2). There is great error in the isochron ages of four molybdenite from copper (molybdenum) ore with diorite porphyrite type, and their weighted average model ages of 14.6±1.2 Ma (MSWD=41), which generally represent the mineralization age. The results about the Re‐Os isotopic dating of molybdenite in the ore of different types have limited exactly that, the minerlazation age of this ore deposits is about 14.09 Ma, which belongs to the middle Miocene mineralization. The Bangpu deposit has a uniform metallogenic dynamics background with the porphyry type and skarn‐type deposits such as Jiama, Qulong and others.
Linkage between Seasonal Insolation Gradient in the Tropical Northern Hemisphere and the Sea Surface Salinity of the Equatorial Indian Ocean during the Last Glacial Period
Authors: RAJEEV Saraswat , RAJIV Nigam , ANDREAS Mackensen , SYEE Weldeab 
Published: October 2012

AbstractPaired stable oxygen isotope and Mg/Ca analyses in calcite tests of the mixed‐layer‐dwelling planktic foraminifer Globigerinoides ruber has been used to reconstruct equatorial Indian Ocean δ18O of seawater (δ18Osw) over the last ∼137 thousand years. On the basis of ice‐volume‐corrected δ18Osw (δ18Osw–ivc), relative changes in sea surface salinity (SSS) have been estimated. The SSS estimates suggest three episodes of higher SSS (131–113 thousand years before present (kyr BP), 62–58 kyr BP, and 30–24 kyr BP) within the last glacial period as compared with the present. SSS comparison between interglacial episodes reveals that the surface seawater over the core site was significantly saltier during the penultimate interglacial than the Holocene. We suggest that the evolution of a seasonal insolation gradient between the Indian monsoon areas and the equator over the investigated time interval was instrumental in shaping the strength of the Indian winter and summer monsoons that left their imprints on the equatorial Indian Ocean SSS via freshwater input and wind‐induced mixing. The study shows that the insolation difference between northern latitudes and the equator during winter affects monsoon strength in the Indian region, especially during cold intervals.
Noise Reduction Technique Applied to the Multichannel Analysis of Surface Waves
Authors: ISLAM Taohidul , CHIK Zamri , MUSTAFA Mohd Marzuki 
Published: October 2012

AbstractThis paper shows the presence of noises and technique to reduce these noises during the surface wave analysis. The frequency‐dependent properties of Rayleigh‐type surface waves can be used for imaging and characterizing the shallow subsurface. Interference by coherent source‐generated noise inhibits the reliability of shear‐wave velocities determined through inversion of the phase velocities of Rayleigh waves. Among these interferences by non‐planar, non‐fundamental mode Rayleigh waves (noise) are body waves, scattered and non‐source‐generated surface waves, and higher‐mode surface waves. For the reduction of noise, the filtering technique is implemented in this paper for the multichannel analysis of surface wave method (MASW). With the de‐noising technique during the MASW method, more robust and reliable outcome is achieved. The significance of this paper is to obtain pre‐awareness about noises during surface wave analysis and take better outcomes with de‐noising performance in near surface soil investigations.
Enantioselective uptake of fexofenadine by Caco-2 cells as model intestinal epithelial cells
Authors: Togami Kohei , Tosaki Yuka , Chono Sumio , Morimoto Kazuhiro , Hayasaka Masataka , Tada Hitoshi 
Published: October 2012

Abstract

Objectives
Fexofenadine contains a chiral carbon in its chemical structure and is orally administered as a racemic mixture. This study evaluated the selective uptake of fexofenadine enantiomers by Caco-2 cells as a model of intestinal epithelial cells.

Methods
R(+)-fexofenadine or S(−)-fexofenadine was applied to Caco-2 cells, followed by incubation. After incubation, the amounts of fexofenadine enantiomers in cells were determined. The kinetic parameters for the uptake of fexofenadine enantiomers by Caco-2 cells were estimated using the Michaelis–Menten equation.

Key findings
The transporter-mediated uptake rate of R(+)-fexofenadine was 1.7-fold higher than that of S(−)-fexofenadine. The difference in transporter-mediated R(+)-fexofenadine and S(−)-fexofenadine uptake was completely diminished under ATP-depleted conditions and in the presence of organic anion transporter peptide (OATP) inhibitors. Also, a Dixon plot showed that each fexofenadine enantiomer was competitively inhibited by the other enantiomer. The ratio of R(+)-fexofenadine uptake to S(−)-fexofenadine uptake in the case of a racemic mixture was higher than that in the case of a single enantiomer.

Conclusion
This study suggested that the selective absorption of fexofenadine enantiomers by intestinal epithelial cells might have been due to the selective uptake mediated by OATPs and that the difference in intestinal absorption was enhanced with a racemic mixture.
Importance of Sinus Rhythm as Endpoint of Persistent Atrial Fibrillation Ablation
Authors: AMMAR SONIA , HESSLING GABRIELE , REENTS TILKO , PAULIK MARIA , FICHTNER STEPHANIE , SCHÖN PATRICK , DILLIER ROGER , KATHAN SUSANNE , JILEK CLEMENS , KOLB CHRISTOF , HALLER BERNHARD , DEISENHOFER ISABEL 
Published: October 2012

Endpoint of Persistent AF Ablation. Background: The endpoint of persistent atrial fibrillation (AF) ablation is still a matter of debate. The purpose of this study was to evaluate if sinus rhythm (SR) as endpoint of persistent AF ablation has a better long‐term outcome compared to atrial tachycardia (AT) or AF at the end of the procedure.Methods and Results: Between 2008 and 2011, 191 consecutive patients undergoing de novo catheter ablation for symptomatic persistent and long‐standing persistent AF using a sequential ablation approach (including pulmonary vein isolation, ablation of complex fractionated electrograms and linear lesions) were included in the study.According to the result at the end of ablation procedure, patients were classified into 3 groups: patients with termination of AF into SR (Group 1, n = 62), patients with AT undergoing cardioversion (CV) (Group 2, n = 47), or patients with AF undergoing CV (Group 3, n = 82).The primary endpoint was freedom from any atrial tachyarrhythmia off antiarrhythmic drugs at 12 months.At 12 months, estimated proportions of patients free from any arrhythmia recurrence were 42% for Group 1, 13% for Group 2, and 25% for Group 3 (P = 0.002).In a Cox regression analysis only termination into SR was associated with a lower risk of arrhythmia recurrence (HR: 0.62; P = 0.04).Conclusion: If SR is achieved as endpoint of persistent and long‐standing persistent AF ablation using a sequential ablation approach it is associated with the highest long‐term single procedure success rate compared to AT or AF at the end of the procedure. (J Cardiovasc Electrophysiol, Vol. 24, pp. 388‐395, April 2013)