bluuebunny/crossref_metadata_2025_split huggingface dataset:
Effectiveness of Pelvic Floor Muscle and Education-Based Therapies on Bladder, Bowel, Vaginal, Sexual, Psychological Function, Quality of Life, and Pelvic Floor Muscle Function in Females Treated for Gynecological Cancer: A Systematic Review
Authors: Cyr Marie-Pierre , Jones Tamara , Brennen Robyn , Colombage Udari , Frawley Helena C. 
Published: August 2024

Abstract
Purpose of Review
Gynecological malignancies are prevalent in females, and this population is likely to experience symptoms of pelvic floor disorders and sexual dysfunction. Non-surgical, non-pharmaceutical conservative therapies, namely pelvic floor muscle (PFM) therapies and education-based interventions, could be beneficial for this population. The purpose of this systematic review was to examine the evidence regarding their effectiveness on bladder, bowel, vaginal, sexual, psychological function, quality of life, and PFM function in gynecological cancer populations.

Recent Findings
Six databases were searched to identify studies employing any interventional study design, except case studies, to investigate the effect of PFM therapies, education-based interventions, or combined therapies on any outcome of interest. The search yielded 4467 results, from which 20 studies were included. Of these, 11 (55%) were RCTs, two (10%) were non-RCTs with two groups, and seven (35%) were non-RCTs with a single group. Findings suggest that combined (multimodal) therapies, specifically PFM (active > passive) + education therapies, appear more effective for vaginal, overall pelvic floor, sexual, and PFM function. PFM therapies (active and/or electrostimulation) may improve bladder outcomes. Limited evidence suggests PFM (active) + education therapies may improve bowel function. Conservative therapies may improve psychological function, although available data do not appear to favor a particular therapy. Given the conflicting findings regarding quality of life, no clear conclusions can be made. Interpretation of findings highlighted the importance of intervention dosage, adherence, and supervision for optimal effectiveness. Despite the limitations of the included studies, this review provides new and valuable insights for future research and clinical practice.
Neuroprotective Effects of VGLUT1 Inhibition in HT22 Cells Overexpressing VGLUT1 Under Oxygen Glucose Deprivation Conditions
Authors: Pomierny B. , Krzyżanowska W. , Skórkowska A. , Budziszewska B. , Pera J. 
Published: August 2024

AbstractGlutamate (Glu) is a major excitatory neurotransmitter in the brain, essential for synaptic plasticity, neuronal activity, and memory formation. However, its dysregulation leads to excitotoxicity, implicated in neurodegenerative diseases and brain ischemia. Vesicular glutamate transporters (VGLUTs) regulate Glu loading into synaptic vesicles, crucial for maintaining optimal extracellular Glu levels. This study investigates the neuroprotective effects of VGLUT1 inhibition in HT22 cells overexpressing VGLUT1 under oxygen glucose deprivation (OGD) conditions. HT22 cells, a hippocampal neuron model, were transduced with lentiviral vectors to overexpress VGLUT1. Cells were subjected to OGD, with pre-incubation of Chicago Sky Blue 6B (CSB6B), an unspecific VGLUT inhibitor. Cell viability, lactate dehydrogenase (LDH) release, mitochondrial membrane potential, and hypoxia-related protein markers (PARP1, AIF, NLRP3) were assessed. Results indicated that VGLUT1 overexpression increased vulnerability to OGD, evidenced by higher LDH release and reduced cell viability. CSB6B treatment improved cell viability and reduced LDH release in OGD conditions, particularly at 0.1 μM and 1.0 μM concentrations. Moreover, CSB6B preserved mitochondrial membrane potential and decreased levels of PARP1, AIF, and NLRP3 proteins, suggesting neuroprotective effects through mitigating excitotoxicity. This study demonstrates that VGLUT1 inhibition could be a promising therapeutic strategy for ischemic brain injury, warranting further investigation into selective VGLUT1 inhibitors.
Effects of Argon in the Acute Phase of Subarachnoid Hemorrhage in an Endovascular Perforation Model in Rats
Authors: Krenzlin Harald , Wesp Dominik M. A. , Korinek Anika A. E. , Ubbens Henning , Volland Jakob , Masomi-Bornwasser Julia , Weber Katharina J. , Mole Dominik , Sommer Clemens , Ringel Florian , Alessandri Beat , Keric Naureen 
Published: August 2024

Abstract
Background
Subarachnoid hemorrhage (SAH) is a devastating disease with high morbidity and mortality. Neuroprotective effects of the noble gas argon have been shown in animal models of ischemia. The aim of this study was to investigate the effects of argon in the immediate early phase of SAH in a rat model.

Methods
A total of 19 male Wistar rats were randomly assigned to three treatment groups. SAH was induced using a endovascular filament perforation model. Cerebral blood flow, mean arterial blood pressure (MAP), and body temperature were measured continuously. Group A received 2 h of ventilation by 50% argon/50% O2 (n = 7) immediately following SAH. Group B underwent a sham operation and was also ventilated by 50% argon/50% O2 (n = 6). Group C underwent SAH and 50% O2/50% N2 ventilation (n = 6). Preoperative and postoperative neurological and behavioral testing were performed. Histology and immunohistochemistry were used to evaluate the extent of brain injury and vasospasm.

Results
The cerebral blood flow dropped in both treatment groups after SAH induction (SAH, 63.0 ± 11.6% of baseline; SAH + argon, 80.2 ± 8.2% of baseline). During SAH, MAP increased (135.2 ± 10.5%) compared with baseline values (85.8 ± 26.0 mm Hg) and normalized thereafter. MAP in both groups showed no significant differences (p = 0.3123). Immunohistochemical staining for neuronal nuclear antigen demonstrated a decrease of hippocampal immunoreactivity after SAH in the cornu ammonis region (CA) 1–3 compared with baseline hippocampal immunoreactivity (p = 0.0127). Animals in the argon-ventilated group showed less neuronal loss compared with untreated SAH animals (p < 0.0001). Ionized calcium-binding adaptor molecule 1 staining showed a decreased accumulation after SAH + argon (CA1, 2.57 ± 2.35%; CA2, 1.89 ± 1.89%; CA3, 2.19 ± 1.99%; DG, 2.6 ± 2.24%) compared with untreated SAH animals (CA1, 5.48 ± 2.39%; CA2, 4.85 ± 4.06%; CA3, 4.22 ± 3.01%; dentate gyrus (DG), 3.82 ± 3.23%; p = 0.0007). The neuroscore assessment revealed no treatment benefit after SAH compared with baseline (p = 0.385).

Conclusion
In the present study, neuroprotective effects of argon occurred early after SAH. Because neurological deterioration was similar in the preadministration and absence of argon, it remains uncertain if neuroprotective effects translate in improved outcome over time.
Maladaptive daydreaming as emotion regulation strategy: exploring the association with emotion regulation, psychological symptoms, and negative problem-solving orientation
Authors: Mancinelli Elisa , Spisto Sara , Sukhija Vinay Jagdish , Salcuni Silvia 
Published: August 2024

AbstractMaladaptive Daydreaming (MD) is a dysfunctional mental activity characterized by an excessive immersion in fantasy, whose function is being increasingly discussed and investigated. Accordingly, this study aims to examine its function as an emotion regulation strategy among MDers by evaluating the pattern of associations among MD, emotion regulation (ER) difficulties, anxiety, depression, stress symptoms, and negative problem-solving orientation. The mediating role of MD level in the association between difficulties in ER and both the psychological distress variables and negative problem-solving orientation was evaluated. N = 252 MDers, aged 18–70 years (Mage = 30.63, SD = 11.40, 84.1% females), participated in the study and completed self-report measures. Some unexpected results emerged: among difficulties in ER’s dimensions, only lack of emotional self-awareness negatively and significantly associated with all symptom variables; solely difficulty pursuing goals when experiencing negative emotions and reduced trust in one’s capacity to self-regulate positively and significantly correlated with MD. MD negatively correlated with depression, anxiety, and negative problem-solving orientation. Three mediation models showed the mediating role of MD in reducing the negative effect of difficulty pursuing goals when experiencing negative emotions on both anxiety and negative problem-solving orientation and of trust in one’s capacity to self-regulate on negative problem-solving orientation. Overall, findings seem to point to functional peculiarities among MDers and support the view of MD as an emotion regulation strategy allowing the management and reduction of negative emotions and negative perceptions of problem situations. Notwithstanding, further research evaluating the potential moderating role of MD-specific fantasies is warranted. Unexpected findings are discussed.
Sponsored senior computers never happened – a 20-year perspective on ICT deployment of healthcare at home!
Authors: Sjöqvist Bengt Arne , Ask Per , Hägglund Sture , Pettersson Nils-Erik , Olsson Jan 
Published: August 2024

Abstract
Purpose
The article studies the utilization of ICT within healthcare at home in Sweden overlooking a perspective of 20 + years. Starting point are articles by the authors from 2002 and 2003. These outlined an already feasible ICT supported healthcare at home as a tool to address healthcare’s identified challenges—a growing elderly population and general demand for more healthcare in combination with issues on financing and lack of human resources. Despite early signals the care transition has been unexpectedly slow. Why?

Methods
With the articles as take-off the journey for ICT based healthcare at home up to today is discussed. In the articles five areas considered as critical for a successful transition were pinpointed and are now used to support the authors considerations, reasoning, and conclusions.

Results
Results indicate that technology has never been a limiting factor. Nor has selected medical issues or expected benefits normally been a limitation. Instead limitations and hindrances are found in other areas and activities.

Conclusions
Technology is not the main challenge when it comes to implementation, instead a focus on business models, deployment, and scaling issues is now advocated. Initiatives also must make more use of gained knowledge and experience. Not doing so delays utilization and deployment. The impact on healthcare effects and expected savings may be over-optimistic. A thorough analysis of all associated costs, consequences, investments, and benefits is recommended. Non-digital alternatives must continue to be offered to these who cannot go digital. In communication improved medical outcome and patient satisfaction must be emphasised.
Utilizing Zebrafish Embryos for Replication of Tulane Virus: A Human Norovirus Surrogate
Authors: Chandran Sahaana , Gibson Kristen E. 
Published: August 2024

AbstractThe zebrafish larvae/embryo model has been shown to support the replication of seven strains (G1.7[P7], GII.2[P16], GII.3[P16], GII.4[P4], GII.4[P16], GII.6[P7], and GII.17[P13]) of human norovirus (HuNoV). However, due to challenges in consistently obtaining HuNoV-positive stool samples from clinical sources, evaluating HuNoV surrogates in this model is highly valuable. This study assesses the potential of zebrafish embryos and larvae as a model for Tulane virus (TuV) replication. Three infection methods were examined: microinjection, immersion, and feeding. Droplet digital PCR was used to quantify viral RNA across all three infection methods. Microinjection of 3 nL of TuV into zebrafish embryos (< 6-h post-fertilization) resulted in significant replication, with viral RNA levels reaching 6.22 logs at 4-day post-infection. In contrast, the immersion method showed no replication after immersing 4-day post-fertilization (dpf) larvae in TuV suspension for 6 h. Similarly, no replication was observed with the feeding method, where Paramecium caudatum loaded with TuV were fed to 4 dpf larvae. The findings indicate that the zebrafish embryo model supports TuV replication through the microinjection method, suggesting that TuV may serve as a useful surrogate for studying HuNoV pathogenesis. Additionally, TuV can be utilized in place of HuNoV in method optimization studies using the zebrafish embryo model, circumventing the limited availability of HuNoV.
Improved Comparison Theorems for the Oscillation of Even Order Delay Differential Equations and their Applications
Authors: Moaaz Osama , Ramos Higinio 
Published: August 2024

AbstractIn this work, only two independent conditions for the oscillation of all solutions of even-order delay differential equations in the non-canonical case are established. Using comparison techniques with first- and second-order delay differential equations, we obtain easy-to-apply criteria that improve previous results in the literature. In addition, we show the importance of our results by applying them to examples that have been frequently used in related works.
Application of magnetic data and satellite spectral imaging in identifying gold mineralization zones and its associated subsurface structures at Fawakheir-Attala area, Central Eastern Desert, Egypt
Authors: Saleh Ahmed , Gabr Safwat S. 
Published: August 2024

AbstractThe Fawakheir-Attala gold mining zone in Egypt’s Central Eastern Desert features a diverse range of rock formations, including Precambrian crystalline rocks and Phanerozoic sedimentary formations. These formations encompass gneisses, metavolcanics, metasediments, a metagabbro-diorite complex, Dokhan volcanic rocks, and granitic rocks, alongside lower and upper Nubia sandstones. Faults and shear zones are pivotal in controlling gold mineralization within the area, indicative of substantial mineral wealth. This study aimed to map subsurface structural characteristics and investigate gold mineralization zones using aerial magnetic data and ASTER remote sensing, the latter of which played a crucial role in highlighting the surface exposure of alteration zones. Geological surveys combined with remote sensing techniques were employed to identify rock types and mineralization zones, while magnetic methods, including aeromagnetic surveys and ground-based studies, were used to reveal underlying structural properties and fault systems. Analysis of aeromagnetic data revealed a large mineralization zone running from the Fawakhir Gold mine through the Attala Gold mine in a NW–SE direction. Various structural trends and faults, including NW–SE, NE–SW, E–W, and N–S directions, were identified, strongly associated with hydrothermal alteration zones and gold mineralization. Shallow basement relief was observed in the eastern and central regions, contrasting with deeper formations and greater relief in the western section. Land magnetic surveys were utilized to identify new areas for gold mineralization, with geochemical analysis confirming gold content in quartz veins and host rocks. The integration of magnetic and remote sensing techniques effectively highlighted alteration zones indicative of potential mineralization, which could have a subsurface continuation, aiding in the identification of gold occurrences connected to faults, lineaments, and mineralization zones.
In vitro glycemic index, acrylamide content, and some physicochemical and sensorial properties of special dried bread (Peksimet) enriched with einkorn wheat (Tiriticum monococcum L.) flour
Authors: Yuksel Ferhat , Çağlar Sümeyye 
Published: August 2024

Abstract
In the present study, einkorn wheat flour (Tiriticum monococcum L.) was incorporated into a special dried bread (peksimet) formulation produced from sourdough breads at different concentrations (0–10–20–30–40 and 50 g 100 g−1) and some physicochemical and nutritional (total dietary fiber, resistant starch, glycemic index, acrylamide content) characteristics and sensory properties of the samples were investigated. The total dietary fiber content of the bread samples ranged from 3.00 to 6.17 g 100 g−1. The highest acrylamide content (247.54 µg/kg) was obtained using an einkorn flour level of 40 g 100 g−1. Einkorn wheat flour resulted in a significant decrease (from 94.61 to 89.23) in the glycemic index level of the bread samples (p < 0.05). Bread enriched with einkorn wheat flour (50.0 g 100 g−1) received the highest overall acceptability score. In conclusion, einkorn wheat flour could be used in a special dried bread formulation to enhance its nutritional quality.
Fabrication of 3D printed mutable drug delivery devices: a comparative study of volumetric and digital light processing printing
Authors: Oh Ye Chan , Ong Jun Jie , Alfassam Haya , Díaz-Torres Eduardo , Goyanes Alvaro , Williams Gareth R. , Basit Abdul W. 
Published: August 2024

AbstractMutable devices and dosage forms have the capacity to dynamically transform dimensionally, morphologically and mechanically upon exposure to non-mechanical external triggers. By leveraging these controllable transformations, these systems can be used as minimally invasive alternatives to implants and residence devices, foregoing the need for complex surgeries or endoscopies. 4D printing, the fabrication of 3D-printed structures that evolve their shape, properties, or functionality in response to stimuli over time, allows the production of such devices. This study explores the potential of volumetric printing, a novel vat photopolymerisation technology capable of ultra-rapid printing speeds, by comparing its performance against established digital light processing (DLP) printing in fabricating hydrogel-based drug-eluting devices. Six hydrogel formulations consisting of 2-(acryloyloxy)ethyl]trimethylammonium chloride solution, lithium phenyl-2,4,6-trimethylbenzoylphosphinate, varying molecular weights of the crosslinking monomer, poly(ethylene glycol) diacrylate, and paracetamol as a model drug were prepared for both vat photopolymerisation technologies. Comprehensive studies were conducted to investigate the swelling and water sorption profiles, drug release kinetics, and physicochemical properties of each formulation. Expandable drug-eluting 4D devices were successfully fabricated within 7.5 s using volumetric printing and were shown to display equivalent drug release kinetics to prints created using DLP printing, demonstrating drug release, swelling, and water sorption properties equivalent to or better than those of DLP-printed devices. The reported findings shed light on the advantages and limitations of each technology for creating these dynamic drug delivery systems and provides a direct comparison between the two technologies, while highlighting the promising potential of volumetric printing and further expanding the growing repertoire of pharmaceutical printing.
Graphical Abstract
Unlocking the potential of digital twins to achieve sustainability in seaports: the state of practice and future outlook
Authors: Homayouni S. Mahdi , Pinho de Sousa Jorge , Moreira Marques Catarina 
Published: August 2024

AbstractThis paper examines the role of digital twins (DTs) in promoting sustainability within seaport operations and logistics. DTs have emerged as promising tools for enhancing seaport performance. Despite the recognized potential of DTs in seaports, there is a paucity of research on their practical implementation and impact on seaport sustainability. Through a systematic literature review, this study seeks to elucidate how DTs contribute to the sustainability of seaports and to identify future research and practical applications. We reviewed and categorized 68 conceptual and practical digital applications into ten core areas that effectively support economic, social, and environmental objectives in seaports. Furthermore, this paper proposes five preliminary potential applications for DTs where practical implementations are currently lacking. The primary findings indicate that DTs can enhance seaport sustainability by facilitating real-time monitoring and decision-making, improving safety and security, optimizing resource utilization, enhancing collaboration and communication, and supporting the development of the seaport ecosystem. Additionally, this study addresses the challenges associated with DT implementation, including high costs, conflicting stakeholder priorities, data quality and availability, and model validation. The paper concludes with a discussion of the implications for seaport managers and policymakers.
Factors for innovation adoption by ports: a systematic literature review
Authors: Sooprayen Krishna , Van de Kaa Geerten , Pruyn Jeroen F. J. 
Published: August 2024

AbstractThis paper investigates the factors influencing innovation adoption in ports by conducting a systematic literature review and proposes a comprehensive framework for understanding the process of innovation adoption. The maritime sector is a typical example of a business-to-business market, whereas the information technology industry is an example of a business-to-consumer market. We show that factors for innovation adoption applicable to a business-to-consumer market are also relevant to a business-to-business market. The factors that were found relate to the adopting port’s characteristics and include know-how, organization support, organizational structure, financial capacity, a port’s network embeddedness, and risk-taking. Furthermore, they concern the characteristics of the innovation such as the costs, relative advantage, complexity, compatibility, trialability, and observability. Finally, stakeholder pressures were identified relating to the customer, competitive port, regulatory bodies, and society.
Study on signal characteristics of burst tendency coal under different loading rates
Authors: Zhou Chao , He Xueqiu , Song Dazhao , Li Zhenlei , Yang Huakang , Liu Yang , Guo Lei 
Published: August 2024

AbstractIn order to study the mechanics, acoustic emission (AE) and electromagnetic emission (EME) response law of bursting liability coal at different loading rates, uniaxial compression tests were carried out on coal mass from Konggu Coal Mine. The corresponding relations among mechanical properties, AE and EME signals in the process of coal failure under loading were analyzed, and the energy evolution law of coal failure with bursting liability under loading rate was discussed. The results show that within a certain range of loading rate, the higher the loading rate, the higher the compressive strength and peak load of bursting liability coal, and the shorter the time for coal to reach the peak load. Under different loading rates, the mechanics, AE and EME signals of coal samples can be well corresponded. When the loading rate is low, the number of blocks destroyed of coal sample is large and the block size is relatively small, and the blocks are mainly scattered around the test platform. When the loading rate is high, the number of damaged blocks is relatively small and the block size is relatively large, and the blocks are far away from the test bench. When loading at a low rate, the internal cracks in coal can be fully developed and connected, and the energy release rate is relatively uniform in the process of loading and failure of coal sample. In the case of high loading rate, the energy release rate of coal sample in the loading process is much smaller than that in the moment of failure. Combining the above test results with the actual situation of the working face, it can be concluded that the total energy stored in the coal of fast mining increases and the threshold of impact decreases compared with that of slow mining. Therefore, under the disturbance of external dynamic load, rapid mining is more likely to induce rock burst.