bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Intelligent Nanotheranostic Agent for Targeting, Redox‐Responsive Ultrasound Imaging, and Imaging‐Guided High‐Intensity Focused Ultrasound Synergistic Therapy
Authors: Wang Xia , Chen Hangrong , Zhang Kun , Ma Ming , Li Faqi , Zeng Deping , Zheng Shuguang , Chen Yu , Jiang Lixin , Xu Huixiong , Shi Jianlin 
Published: November 2013

A novel multifunctional nanotheranostic agent with targeting, redox‐responsive ultrasound imaging and ultrasound imaging‐guided high‐intensity focused ultrasound (HIFU) therapy (MSNC‐PEG‐HASS‐PFH, abbreviated as MPHSS‐PFH) capabilities is developed. The redox‐responsive guest molecule release and ultrasound imaging functions can be both integrated in such a “smart” theranostic agent, which is accomplished by the redox‐triggered transition from the crosslinking state to retrocrosslinking state of the grafted polyethylene glycol‐disulfide hyaluronic acid molecules on the particle surface when reaching a reducing environment in vitro. More importantly, under the tailored ultrasound imaging guiding, in vivo Hela tumor‐bearing nude mice can be thoroughly and spatial‐accurately ablated during HIFU therapy, due to the targeted accumulation, responsive ultrasound imaging guidance and the synergistic ablation functions of nanotheranostic agent MPHSS‐PFH in the tumors. This novel multifunctional nano‐platform can serve as a promising candidate for further studies on oncology therapy, due to its high stability, responsive and indicative ultrasound imaging of tumors, and enhanced HIFU therapeutic efficiency and spatial accuracy under ultrasound‐guidance.
Brückenlager sprengen
Authors: Mende Volker 
Published: November 2013

AbstractTrotz der Relevanz für die Brückeninstandhaltung finden vorhandene Minenanlagen in Brückenpfeilern in der Fachliteratur keinerlei Beachtung. Der Beitrag untersucht die Entwicklungsgeschichte dieser Anlagen in Deutschland seit Mitte des 19. Jahrhunderts. Es wird dargestellt, welche konstruktiven Auswirkungen Minenanlagen auf Pfeiler und Auflagerbereiche hatten und noch immer haben.Demolishing bridge bearings – Bridge pillars with permanent mine chambers. Bridge pillars with permanent mine chambers are not noted in technical literature and bridge maintenance. This paper explores an outline history of these constructions, executed in Germany since 19th century. Discussing the constructive effects of mine chambers, the ongoing influences to bridge pillars and bearings will be pointed out.
A combination of genetic algorithm‐based fuzzy C‐means with a convex hull‐based regression for real‐time fuzzy switching regression analysis: application to industrial intelligent data analysis
Authors: Azhar Ramli Azizul , Watada Junzo , Pedrycz Witold 
Published: November 2013

AbstractProcessing an increasing volume of data, especially in industrial and manufacturing domains, calls for advanced tools of data analysis. Knowledge discovery is a process of analyzing data from different perspectives and summarizing the results into some useful and transparent findings. To address such challenges, a thorough extension and generalization of well‐known techniques such as regression analysis becomes essential and highly advantageous. In this paper, we extend the concept of regression models so that they can handle hybrid data coming from various sources which quite often exhibit diverse levels of data quality. The major objective of this study is to develop a sound vehicle of a hybrid data analysis, which helps in reducing the computing time, especially in cases of real‐time data processing. We propose an efficient real‐time fuzzy switching regression analysis based on a genetic algorithm‐based fuzzy C‐means associated with a convex hull‐based fuzzy regression approach. The method enables us to deal with situations when one has to deal with heterogeneous data which were derived from various database sources (distributed databases). In the proposed design, we emphasize a pivotal role of the convex hull approach, which is essential to alleviate the limitations of linear programming when being used in modeling of real‐time systems. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Refinement of inverter model considering dead‐time for performance improvement in predictive instantaneous current control
Authors: Imura Akihiro , Takahashi Tomoya , Fujitsuna Masami , Zanma Tadanao , Doki Shinji 
Published: November 2013

AbstractModel predictive instantaneous‐current control (MPIC), which was proposed in our earlier works, enables us to achieve better instantaneous current control using mathematical models of an inverter and permanent magnet synchronous motors (PMSMs). However, dead‐time to avoid short breakdown in the inverter is not usually considered in a general inverter model. Such an unmodeled part in the inverter model prevents accurate prediction of current evolution in motor systems based on the model predictive control. Therefore, in this paper, we analyze current response resulting from the dead‐time in the MPIC, and propose a refined inverter model considering the dead‐time so that control performance is improved. The effectiveness of the proposed method is verified through simulation and experiments. © 2013 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
The 50:50 method for PCR‐based seamless genome editing in yeast
Authors: Horecka Joe , Davis Ronald W. 
Published: November 2013

AbstractThe ability to edit the yeast genome with relative ease has contributed to the organism being a model eukaryote for decades. Most methods for deleting, inserting or altering genomic sequences require transformation with DNA that carries the desired change and a selectable marker. One‐step genome editing methods retain the selectable marker. Seamless genome editing methods require more steps and a marker that can be used for both positive and negative selection, such as URA3. Here we describe the PCR‐based 50:50 method for seamless genome editing, which requires only two primers, one PCR with a URA3 cassette, and a single yeast transformation. Our method is based on pop‐in/pop‐out gene replacement and is amenable to the facile creation of genomic deletions and short insertions or substitutions. We used the 50:50 method to make two conservative loss‐of‐function mutations in MATα1, with results suggesting that the wild‐type gene has a new function outside of that presently known. Copyright © 2013 John Wiley & Sons, Ltd.
Hexa‐ to Octamolybdate Rearrangement leads to the New Coordination Polymer [Ag(PhCN)(thb)]4[β‐Mo8O26](PhCN)2
Authors: Kulikov Vladislav , Meyer Gerd 
Published: November 2013

AbstractPolyoxomolybdates tend to re‐agglomerate to β‐octamolybdate upon reaction with Ag+ under hydrothermal conditions and in organic solvents. Consistent with this tendency, a new coordination polymer [Ag(PhCN)(thb)]4[β‐Mo8O26](PhCN)2 (thb = theobromine) (1) was obtained and characterized by single crystal XRD, powder XRD, DTA/TG, IR, UV/Vis, and elemental analysis. 1 is a one‐dimensional coordination polymer, in which octamolybdate anions are joined by [Ag(PhCN)(thb)]+ cations along the crystallographic a axis. A firm network of intermolecular interactions, especially between self‐pairing thb ligands, interlinks these chains. Salt 1 is turned into MoO2 and Ag upon thermolysis in an intramolecular redox reaction.
Synthesis, Crystal Structure, and Magnetic Properties of Two Manganese(II) and Cobalt(II) Coordination Polymers Based on Biphenyl‐3, 3′,4, 4′‐tetracarboxylic Acid
Authors: Song Juan , Shu Hui‐Ming , Hu Huai‐Ming , Liu Bin , Han Zhong‐Xi , Xue Gan‐Lin 
Published: November 2013

Abstract Two coordination polymers, [Mn2(btc)(phen)4]n·7nH2O (1) and [Co2(btc)(phen)(H2O)2]n·nH2O (2) (H4btc = biphenyl‐3, 3′,4, 4′‐tetracarboxylic acid, phen = 1, 10‐phenanthroline) were hydrothermally synthesized and characterized by elemental analysis, IR spectroscopy, and single‐crystal X‐ray diffraction. Compound 1 has a 1D chain structure in which the dinuclear Mn2 units are linked through (btc)4– ligands. Magnetic measurements revealed weak antiferromagnetic and ferromagnetic exchange coupling interactions between MnII and CoII ions in 1 and 2, respectively. Moreover, both compounds have good thermal stabilities.
Brain creatine depletion in vegetarians? A cross-sectional 1H-magnetic resonance spectroscopy (1H-MRS) study
Authors: Yazigi Solis Marina , de Salles Painelli Vítor , Giannini Artioli Guilherme , Roschel Hamilton , Concepción Otaduy Maria , Gualano Bruno 
Published: November 2013

The present cross-sectional study aimed to examine the influence of diet on brain creatine (Cr) content by comparing vegetarians with omnivores. Brain Cr content in the posterior cingulate cortex was assessed by proton magnetic resonance spectroscopy (1H-MRS). Dietary Cr intake was assessed by 3 d food recalls. Vegetarians had lower dietary Cr intake than omnivores (0·03 (sd 0·01) v. 1·34 (sd 0·62) g/d, respectively; P= 0·005). However, vegetarians and omnivores had comparable brain total Cr content (5·999 (sd 0·811) v. 5·917 (sd 0·665) IU, respectively; P= 0·77). In conclusion, dietary Cr did not influence brain Cr content in healthy individuals, suggesting that in normal conditions brain is dependent on its own Cr synthesis.
Care managers' experiences of cross-cultural needs assessment meetings: the case of late-in-life immigrants
Authors: FORSSELL EMILIA , TORRES SANDRA , OLAISON ANNA 
Published: November 2013

ABSTRACTResearch on care managers' experiences of the needs assessment process is scarce even though the literature on needs assessment practice is relatively extensive. One of the research areas that has not received attention yet is the way in which care managers experience the challenges that are presumably posed by increased ethnic, cultural, linguistic and religious diversity among prospective elder care recipients. This article addresses this research gap. It is based on a project that aims to shed light on care managers' experiences of the needs assessment process in general and cross-cultural needs assessment meetings in particular. The data are constituted of focus group interviews with care managers in Sweden (N=60). In this article we focus on care managers' experiences of needs assessment with older people who have immigrated late-in-life, who come from cultures considered different from the Swedish one and who have not mastered the Swedish language. This was the group of older people that the care managers mostly thought of when asked to describe their experiences of cross-cultural needs assessment meetings. The interviewed care managers discussed the challenges that these meetings present, which were related to communication due to language barriers, different demands and expectations, insecurity regarding what is customary in such meetings, as well as perceived passivity among late-in-life immigrants. The article discusses the contributions of the findings to research on care management practices in general, as well as to needs assessment practice in particular.
Property T for general C*-algebras
Authors: NG CHI–KEUNG 
Published: November 2013

AbstractIn this paper, we extend the definition of property T and strong property T to general C*-algebras (not necessarily unital). We show that if an inclusion pair of locally compact groups (G,H) has property T, then (C*(G), C*(H)) has property T. As a partial converse, if T is abelian and C*(G) has property T, then T is compact. We also show that if Ω is a first countable locally compact Hausdorff space, then C0(Ω) has (strong) property T if and only if Ω is discrete. Furthermore, the non-unital C*-algebra $c_0(\mathbb{Z}^n)\rtimes SL_n(\mathbb{Z})$ has strong property T when n ≥ 3. We also give some equivalent forms of strong property T, which are new even in the unital case.
Oviductal and endometrial mRNA expression of implantation candidate biomarkers during early pregnancy in rabbit
Authors: Saeed Ayman Moustafa , Saenz de Juano María de los Desamparados , Marco Jiménez Francisco , Vicente José Salvador 
Published: November 2013

SummaryPrenatal losses are a complex problem. Pregnancy requires orchestrated communication between the embryo and the uterus that includes secretions from the embryo to signal pregnancy recognition and secretion and remodelling from the uterine epithelium. Most of these losses are characterized by asynchronization between embryo and uterus. To better understand possible causes, an analysis was conducted of gene expression of a set of transcripts related to maternal recognition and establishment of rabbit pregnancy (uteroglobin,SCGB1A1; integrin α1,ITGA1; interferon-γ,IFNG; vascular endothelial growth factor,VEGF) in oviduct and uterine tissue at 16, 72 or 144 h post-ovulation and insemination. In the oviduct tissue, a significant decrease in the level ofSCGB1A1mRNA expression was observed from 144 h post-ovulation. In the case ofITGA1, the transcript abundance was initially lower, but mRNA expression increased significantly at 72 and 144 h post-ovulation. ForIFNG, a huge decrease was observed from 16 to 72 h post-ovulation. Finally, no significant differences were observed in theVEGFtranscript. For the endometrium, the results showed a significant decline in the level ofSCGB1A1mRNA expression from 16 to 144 h post-ovulation induction. The highest levels ofITGA1transcript were detected at 144 h, followed by the 16 h group and lower at 72 h post-ovulation. ForIFNGthere were no significant differences among post-ovulation induction times. Finally, it was possible to observe thatVEGFmRNA abundance was present at low levels at 16 h post-ovulation and remained low at 72 h, but increased at 144 h. The functional significance of these observations may provide new insights into the maternal role in prenatal losses.
A Palaeocene intracanyon-style lava emplaced during the early shield-building stage of the Cuillin Volcano, Isle of Skye, NW Scotland
Authors: Bell Brian R. , Williamson Ian T. 
Published: November 2013

ABSTRACTThe twin summits of Preshal More and Preshal Beg, near Talisker, Isle of Skye, comprise the erosional remnants of a thick (at least 120 m) compound olivine tholeiite lava, or flow field, that ponded in palaeo-valleys within the Palaeocene lava field of west-central Skye. This unique flow field constitutes the Talisker Formation and is the youngest preserved extrusive unit of the Skye Lava Field. The lava inundated a complex of palaeo-valleys incised into the higher stratigraphical levels of the existing lava field, and remnants of the original sedimentary fill of these valleys still exist, the Preshal Beg Conglomerate Formation. The lava displays spectacularly well-developed two-tier (colonnade-entablature) columnar joint sets that formed as a consequence of slow, uninterrupted cooling through its base and sidewalls, aided by groundwater circulation and water ingress (from displaced drainage) directed into the lava's interior by master-joint systems. Intrusive phenomena developed at both the base and the top of the lava and there is evidence for the existence of subsurface feeder tubes. The tholeiitic composition of the Talisker Formation lava contrasts with the transitional, mildly alkaline characteristics of the remainder of the (older) lavas of Skye Lava Field. In broad terms, the Talisker Formation lava is compositionally very similar to the suite of cone-sheets emplaced into the oldest of the four intrusive centres that comprise the Skye Central Complex – the Cuillin Intrusive Centre – together with a high proportion of the Skye regional dyke swarm. The stratigraphical position, field relationships and compositional characteristics of the lava indicate that it was erupted and emplaced as an intracanyon-style flow field during the early shield-building stage in the growth of the (tholeiitic) Cuillin Volcano, which post-dates the main Skye ‘plateau’ Lava Field. Although the remnant outcrops are detached from their likely source area through erosion, this tholeiitic lava provides the first direct evidence linking the central complexes of the British Palaeogene Igneous Province and their eruptive products.
High quantum efficiency deep ultraviolet 4H‐SiC photodetectors
Authors: Sampath A.V. , Rodak L.E. , Chen Y. , Zhou Q. , Campbell J.C. , Shen H. , Wraback M. 
Published: November 2013

4H‐SiC p‐n−‐metal photodetectors are demonstrated having high external quantum efficiency >∼40% in the deep ultraviolet spectrum between 200 and 235 nm. This improvement is attributed to the improved collection of carriers generated by deep ultraviolet photons through absorption in the depletion region of the detector.
Crop wild relatives and climate change.
Authors: Maxted N. , Kell S. , Brehm J. M. 
Published: November 2013

Abstract

This chapter provides an analysis of the importance of crop wild relatives (CWR) in plant breeding and the need for their comprehensive conservation. The importance of CWR diversity as a potentially critical resource for future food security is now widely recognized, particularly in the light of climate change and the rapidly increasing human population. The need to conserve CWR diversity has been placed firmly on the international conservation agenda. CWR diversity through trait transfer offers one means of helping sustain food production under the rapidly changing environmental conditions brought about by climate change.
Climate change and on-farm conservation of crop landraces in centres of diversity.
Authors: Bellon M. R. , Etten J. van 
Published: November 2013

Abstract

This chapter reviews the potential impacts of climate change on on-farm conservation of crop diversity and on the contribution that on-farm conservation can make to agricultural adaptation to climate change, and ask two questions: (1) How might climate change affect the viability of on-farm conservation of landraces in centres of crop diversity? and (2) How can on-farm conservation contribute to the adaptation of small-scale farmers to climate change?
Germplasm databases and informatics.
Authors: Ougham H. , Thomas I. D. 
Published: November 2013

Abstract

This chapter discusses the data management aspects of germplasm collections. It describes several developments in genetic resources databases, and regional projects aimed at facilitating conservation and use. It focuses solely on germplasm databases, specifically those that are publicly accessible through the World Wide Web and that are hosted and curated by well-established organizations, although there are, or have been, numerous other such databases. An additional criterion for choosing the databases introduced in this chapter is that they catalogue germplasm (generally conserved ex situ in genebanks) much of which is available free of charge (such as the collections held in the centres of the Consultative Group on International Agricultural Research) or may possibly be for purchase at a modest price.
Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching
Authors: Robinson Kirsten E. , Orans Jillian , Kovach Alexander R. , Link Todd M. , Brennan Richard G. 
Published: November 2013

AbstractHfq is a posttranscriptional riboregulator and RNA chaperone that binds small RNAs and target mRNAs to effect their annealing and message-specific regulation in response to environmental stressors. Structures of Hfq-RNA complexes indicate that U-rich sequences prefer the proximal face and A-rich sequences the distal face; however, the Hfq-binding sites of most RNAs are unknown. Here, we present an Hfq-RNA mapping approach that uses single tryptophan-substituted Hfq proteins, all of which retain the wild-type Hfq structure, and tryptophan fluorescence quenching (TFQ) by proximal RNA binding. TFQ properly identified the respective distal and proximal binding of A15 and U6 RNA to Gram-negative Escherichia coli (Ec) Hfq and the distal face binding of (AA)3A, (AU)3A and (AC)3A to Gram-positive Staphylococcus aureus (Sa) Hfq. The inability of (GU)3G to bind the distal face of Sa Hfq reveals the (R-L)n binding motif is a more restrictive (A-L)n binding motif. Remarkably Hfq from Gram-positive Listeria monocytogenes (Lm) binds (GU)3G on its proximal face. TFQ experiments also revealed the Ec Hfq (A-R-N)n distal face-binding motif should be redefined as an (A-A-N)n binding motif. TFQ data also demonstrated that the 5′-untranslated region of hfq mRNA binds both the proximal and distal faces of Ec Hfq and the unstructured C-terminus.
Spatio-temporal requirements for transposable element piRNA-mediated silencing duringDrosophilaoogenesis
Authors: Dufourt Jérémy , Dennis Cynthia , Boivin Antoine , Gueguen Nathalie , Théron Emmanuelle , Goriaux Coline , Pouchin Pierre , Ronsseray Stéphane , Brasset Emilie , Vaury Chantal 
Published: November 2013

AbstractDuring Drosophila oogenesis, transposable element (TE) repression involves the Piwi-interacting RNA (piRNA) pathway which ensures genome integrity for the next generation. We developed a transgenic model to study repression of the Idefix retrotransposon in the germline. Using a candidate gene KD-approach, we identified differences in the spatio-temporal requirements of the piRNA pathway components for piRNA-mediated silencing. Some of them (Aub, Vasa, Spn-E) are necessary in very early stages of oogenesis within the germarium and appear to be less important for efficient TE silencing thereafter. Others (Piwi, Ago3, Mael) are required at all stages of oogenesis. Moreover, during early oogenesis, in the dividing cysts within the germarium, Idefix anti-sense transgenes escape host control, and this is associated with very low piwi expression. Silencing of P-element-based transgenes is also strongly weakened in these cysts. This region, termed the ‘Piwiless pocket’ or Pilp, may ensure that new TE insertions occur and are transmitted to the next generation, thereby contributing to genome dynamics. In contrast, piRNA-mediated silencing is strong in germline stem cells in which TE mobilization is tightly repressed ensuring the continued production of viable germline cysts.
Collaboration between CpG sites is needed for stable somatic inheritance of DNA methylation states
Authors: Haerter Jan O. , Lövkvist Cecilia , Dodd Ian B. , Sneppen Kim 
Published: November 2013

AbstractInheritance of 5-methyl cytosine modification of CpG (CG/CG) DNA sequences is needed to maintain early developmental decisions in vertebrates. The standard inheritance model treats CpGs as independent, with methylated CpGs maintained by efficient methylation of hemimethylated CpGs produced after DNA replication, and unmethylated CpGs maintained by an absence of de novo methylation. By stochastic simulations of CpG islands over multiple cell cycles and systematic sampling of reaction parameters, we show that the standard model is inconsistent with many experimental observations. In contrast, dynamic collaboration between CpGs can provide strong error-tolerant somatic inheritance of both hypermethylated and hypomethylated states of a cluster of CpGs, reproducing observed stable bimodal methylation patterns. Known recruitment of methylating enzymes by methylated CpGs could provide the necessary collaboration, but we predict that recruitment of demethylating enzymes by unmethylated CpGs strengthens inheritance and allows CpG islands to remain hypomethylated within a sea of hypermethylation.