bluuebunny/crossref_metadata_2025_split huggingface dataset:
Novel Intercluster Compounds Composed of a Tetra{phosphanegold(I)}oxonium Cation and an α-Keggin Polyoxometalate Anion Linked by Three Monomeric Phosphanegold(I) Units
Authors: Yoshida Takuya , Matsunaga Satoshi , Nomiya Kenji 
Published: August 2013

Abstract
Using highly negatively charged Keggin polyoxometalates (POMs), [α-XW12O40]5− (X = Al and B), novel intercluster compounds composed of a tetrakis{triphenylphosphanegold(I)}oxonium cation and an α-Keggin POM linked by three monomeric triphenylphosphanegold(I) units were prepared. A single peak was observed in the solution 31P{1H} NMR for these clusters, which is consistent with rapid exchange of the phosphanegold(I) units in the tetra{phosphanegold(I)}oxonium cluster cation with the three monomeric phosphanegold(I) species linked to the POM. Importantly, these compounds may be relevant transition states or intermediates in POM-mediated tetra{phosphanegold(I)}oxonium cluster formation.
Coronal plane partial articular fractures of the distal femoral condyle
Authors: Arastu M. H. , Kokke M. C. , Duffy P. J. , Korley R. E. C. , Buckley R. E. 
Published: August 2013

Coronal plane fractures of the posterior femoral condyle, also known as Hoffa fractures, are rare. Lateral fractures are three times more common than medial fractures, although the reason for this is not clear. The exact mechanism of injury is likely to be a vertical shear force on the posterior femoral condyle with varying degrees of knee flexion. These fractures are commonly associated with high-energy trauma and are a diagnostic and surgical challenge. Hoffa fractures are often associated with inter- or supracondylar distal femoral fractures and CT scans are useful in delineating the coronal shear component, which can easily be missed. There are few recommendations in the literature regarding the surgical approach and methods of fixation that may be used for this injury. Non-operative treatment has been associated with poor outcomes. The goals of treatment are anatomical reduction of the articular surface with rigid, stable fixation to allow early mobilisation in order to restore function. A surgical approach that allows access to the posterior aspect of the femoral condyle is described and the use of postero-anterior lag screws with or without an additional buttress plate for fixation of these difficult fractures. Cite this article: Bone Joint J 2013;95-B:1165–71.
Degenerative retrolisthesis
Authors: Jeon C-H. , Park J-U. , Chung N-S. , Son K-H. , Lee Y-S. , Kim J-J. 
Published: August 2013

We investigated the spinopelvic morphology and global sagittal balance of patients with a degenerative retrolisthesis or anterolisthesis. A total of 269 consecutive patients with a degenerative spondylolisthesis were included in this study. There were 95 men and 174 women with a mean age of 64.3 years (sd 10.5; 40 to 88). A total of 106 patients had a pure retrolisthesis (R group), 130 had a pure anterolisthesis (A group), and 33 had both (R+A group). A backward slip was found in the upper lumbar levels (mostly L2 or L3) with an almost equal gender distribution in both the R and R+A groups. The pelvic incidence and sacral slope of the R group were significantly lower than those of the A (both p < 0.001) and R+A groups (both p < 0.001). The lumbar lordosis of the R+A group was significantly greater than that of the R (p = 0.025) and A groups (p = 0.014). The C7 plumb line of the R group was located more posteriorly than that of the A group (p = 0.023), but was no different from than that of the R+A group (p = 0.422). The location of C7 plumb line did not differ between the three groups (p = 0.068). The spinosacral angle of the R group was significantly smaller than that of the A group (p < 0.001) and R+A group (p < 0.001). Our findings imply that there are two types of degenerative retrolisthesis: one occurs primarily as a result of degeneration in patients with low pelvic incidence, and the other occurs secondarily as a compensatory mechanism in patients with an anterolisthesis and high pelvic incidence. Cite this article: Bone Joint J 2013;95-B:1244–9.
Early outcomes of staged bilateral reverse total shoulder arthroplasty
Authors: Wiater B. P. , Boone C. R. , Koueiter D. M. , Wiater J. M. 
Published: August 2013

Some surgeons are reluctant to perform a reverse total shoulder arthroplasty (RTSA) on both shoulders because of concerns regarding difficulty with activities of daily living post-operatively as a result of limited rotation of the shoulders. Nevertheless, we hypothesised that outcomes and patient satisfaction following bilateral RTSA would be comparable to those following unilateral RTSA. A single-surgeon RTSA registry was reviewed for patients who underwent bilateral staged RTSA with a minimum follow-up of two years. A unilateral RTSA matched control was selected for each shoulder in those patients undergoing bilateral procedures. The Constant–Murley score (CMS), American Shoulder and Elbow Surgeons (ASES) score, Subjective Shoulder Values (SSV), visual analogue scale (VAS) for pain, range of movement and strength were measured pre- and post-operatively. The mean CMS, ASES, SSV, VAS scores, strength and active forward elevation were significantly improved (all p < 0.01) following each operation in those undergoing bilateral procedures. The mean active external rotation (p = 0.63 and p = 0.19) and internal rotation (p = 0.77 and p = 0.24) were not significantly improved. The improvement in the mean ASES score after the first RTSA was greater than the improvement in its control group (p = 0.0039). The improvement in the mean CMS, ASES scores and active forward elevation was significantly less after the second RTSA than in its control group (p = 0.0244, p = 0.0183, and p = 0.0280, respectively). Pain relief and function significantly improved after each RTSA in those undergoing a bilateral procedure.Bilateral RTSA is thus a reasonable form of treatment for patients with severe bilateral rotator cuff deficiency, although inferior results may be seen after the second procedure compared with the first.Cite this article: Bone Joint J 2013;95-B:1232–8.
Gastrocnemius flap reconstruction of soft-tissue defects following infected total knee replacement
Authors: Corten K. , Struelens B. , Evans B. , Graham E. , Bourne R. B. , MacDonald S. J. 
Published: August 2013

A soft-tissue defect over an infected total knee replacement (TKR) presents a difficult technical problem that can be treated with a gastrocnemius flap, which is rotated over the defect during the first-stage of a revision procedure. This facilitates wound healing and the safe introduction of a prosthesis at the second stage. We describe the outcome at a mean follow-up of 4.5 years (1 to 10) in 24 patients with an infected TKR who underwent this procedure. A total of 22 (92%) eventually obtained a satisfactory result. The mean Knee Society score improved from 53 pre-operatively to 103 at the latest follow-up (p < 0.001). The mean Western Ontario and McMaster Universities osteoarthritis index and Short-Form 12 score also improved significantly (p < 0.001).This form of treatment can be used reliably and safely to treat many of these complex cases where control of infection, retention of the components and acceptable functional recovery are the primary goals.Cite this article: Bone Joint J 2013;95-B:1217–21.
Long-term results of the Hohmann and Lapidus procedure for the correction of hallux valgus
Authors: Faber F. W. M. , van Kampen P. M. , Bloembergen M. W. 
Published: August 2013

As it remains unproven that hypermobility of the first tarsometatarsal joint (TMTJ-1) is a significant factor in hallux valgus deformity, the necessity for including arthrodesis of TMTJ-1 as part of a surgical correction of a hallux valgus is questionable. In order to evaluate the role of this arthrodesis on the long-term outcome of hallux valgus surgery, a prospective, blinded, randomised study with long-term follow-up was performed, comparing the Lapidus procedure (which includes such an arthrodesis) with a simple Hohmann distal closing wedge metatarsal osteotomy. The study cohort comprised 101 feet in 87 patients: 50 feet were treated with a Hohmann procedure and 51 with a Lapidus procedure. Hypermobility of TMTJ-1 was assessed pre-operatively by clinical examination. After a mean of 9.25 years (7.25 to 11.42), 91 feet in 77 patients were available for follow-up. There was no difference in clinical or radiological outcome between the two procedures. Also, there was no difference in outcome between the two procedures in the subgroup clinically assessed as hypermobile. This study does not support the theory that a hallux valgus deformity in a patient with a clinically assessed hypermobile TMTJ-1 joint requires fusion of the first tarso-metatarsal joint.Cite this article: Bone Joint J 2013;95-B:1222–6.
Don't forget your hammer if you want to go to work!
Authors: Draman Mohd Shazli , Brennan Aoife , Cullen Michael , Nolan John 
Published: August 2013

Summary
Bilateral lower limb paraesthesia is a common diabetic neuropathy presentation in any busy diabetic clinics. We present a case of a 28-year-old man with a long history of type 1 diabetes mellitus presented with bilateral paraesthesia of both feet and unsteady gait. The patient was able to feel a 10 g monofilament. The presence of brisk reflexes and upgoing plantars in this patient were pointers that further evaluation was warranted. Further investigations revealed diagnosis of subacute combined degeneration of spinal cord. The patient had rapid symptomatic improvement with i.m. vitamin B12 injection. The high volume of patients attending the outpatients with diabetes and paraesthesia can blind us to other possible diagnoses. This article emphasizes that peripheral neuropathy in a diabetic may be due to aetiologies other than diabetes.

Learning points

Pernicious anaemia is known to be more common in patients with type 1 diabetes.

Cobalamin deficiency is reversible if detected early enough and treated by B12 replacement.

By contrast, diabetic neuropathy is generally a progressive complication of diabetes.

Peripheral neuropathy in a diabetic may be due to aetiologies other than diabetes.
Haptoglobin 1-1 Genotype Is Associated With Poorer Cognitive Functioning in the Elderly With Type 2 Diabetes
Authors: Ravona-Springer Ramit , Heymann Anthony , Schmeidler James , Guerrero-Berroa Elizabeth , Sano Mary , Preiss Rachel , Koifman Keren , Hoffman Hadas , Levy Andrew , Silverman Jeremy M. , Schnaider-Beeri Michal 
Published: August 2013

OBJECTIVE
Haptoglobin (Hp) genotype (Hp 1-1, 1-2, or 2-2) is associated with risk for type 2 diabetes complications, but its relationship with cognitive compromise, a growing concern in type 2 diabetes, has rarely been studied. This study investigated whether Hp genotype is associated with cognitive function in cognitively normal elderly diabetic subjects.

RESEARCH DESIGN AND METHODS
Relationships of Hp genotype with episodic memory, semantic categorization, attention/working memory and executive function, and an overall cognitive score were examined in subjects from the Israel Diabetes and Cognitive Decline (IDCD) study.

RESULTS
In the present analysis, 812 subjects participated (84 with Hp 1-1, 335 with Hp 1-2, and 393 with Hp 2-2 genotypes). Average was 72.9 years of age (SD 4.7), and Mini-Mental State Exam (MMSE) was 28.0 (SD 1.8). Compared with subjects with Hp 1-2 genotype, Hp 1-1 subjects performed significantly worse in semantic categorization (F = 7.03; P = 0.008) and the overall cognitive score (F = 5.57; P = 0.02). A separate stepwise multiple regression analysis demonstrated that compared with subjects with Hp 2-2 genotype, Hp 1-1 subjects performed significantly worse in semantic categorization (F = 4.18; P = 0.04) and the overall cognitive score (F = 4.70; P = 0.03). The contribution of cardiovascular risk factors to cognition was significantly higher in subjects with Hp 1-1 genotype compared with Hp 2 carriers (Hp 1-2 and Hp 2-2) in the semantic categorization (P = 0.009) and attention/working memory (P = 0.002) cognitive domains.

CONCLUSIONS
Compared with Hp 2 carriers, those with Hp 1-1 genotype present lower cognitive performance. Stronger relationships between cardiovascular risk factors and cognition in the latter group may suggest an underlying vascular mechanism.
Helminth Parasites of the Three Racerunner Lizards: Eremias pleskei Nikolsky, 1905 (Pleske’s Racerunner-Transcaucasian Racerunner), Eremias strauchi Kessler, 1878 (Strauch’s Racerunner) and Eremias suphani Basoglu & Hellmich, 1968 (Suphan Racerunner) collected from Eastern Part of Turkey
Authors: Düşen S. , Kumlutaş Y. , Ilgaz Ç. , Yaka H. , Karadayi F. 
Published: August 2013

Abstract
In this investigation, a total of 44 racerunner lizard samples (Eremias pleskei, Eremias strauchi, and Eremias suphani) collected from eastern part of Turkey were examined for the first time for helminths. Eremias pleskei was harboured 1 species of acanthocepalan (in cystacanth stage), E. strauchi was harboured 2 species of nematodes, and E. suphani was harboured 3 species of nematodes and 1 species of cestode. E. strauchi represents a new host record for Spauligodon eremiasi, and Spauligodon saxicolae E. suphani represents a new host record for Spauligodon eremiasi, S. saxicolae, Physaloptera sp., and Oochoristica tuberculata, and also, E. pleskei represents a new host record for unidentified acanthocepalan (in cystacanth stage). Also, Turkey is a new locality record for Spauligodon eremiasi.
Comparison of Lumbar Proprioception as Measured in Unrestrained Standing in Individuals With Disc Replacement, With Low Back Pain and Without Low Back Pain
Authors: Hobbs Amanda J. , Adams Roger D. , Shirley Debra , Hillier Terence M. 
Published: August 2013

Study Design Cross-sectional laboratory study. Objective To determine whether individuals with spinal pain and those who have undergone spinal surgery have difficulty discriminating small movement differences using a spinal proprioception test for active flexion movements. Background Structures contributing to proprioception may be affected during disc replacement surgery. Postsurgical assessment of proprioceptive ability to make discriminations in the range used for maintaining upright postural stability is needed to inform postoperative rehabilitation. Methods Proprioceptive sensitivity to differences between lumbar spine movements of 11°, 13°, 15°, 17°, and 19° of forward flexion was measured in unrestrained standing, with vision of the target obscured. Individuals after disc replacement (n = 16), with disc degeneration and discogenic back pain (n = 19), and without back pain (n = 18) performed 50 movement trials and stated the amount of movement performed for each trial (11°, 13°, 15°, 17°, or 19°). Results The pattern of discrimination scores between adjacent lumbar flexion movement pairs shown by the individuals in the discogenic back pain group differed significantly from the disc replacement and healthy control groups (P = .024), which were not significantly different from each other. Although mean discrimination scores averaged over all movement pairs did not differ significantly between the groups, participants with discogenic back pain discriminated between the 2 smallest lumbar flexion movements significantly better than those in the other 2 groups (P = .013). Conclusion The greater sensitivity of the individuals with disc pain to discriminate between the 2 smallest flexion movements was interpreted as a contrast effect arising from differences between the groups in usual upright posture, with disc replacement restoring the same pattern of posture as seen for healthy controls. J Orthop Sports Phys Ther 2010;40(7):439‱446. doi:10.2519/jospt.2010.3149
The prevalence of patient safety indicators and hospital-acquired conditions in patients with ruptured cerebral aneurysms: establishing standard performance measures using the Nationwide Inpatient Sample database
Authors: Fargen Kyle M. , Neal Dan , Rahman Maryam , Hoh Brian L. 
Published: August 2013

Object
The Agency for Healthcare Research and Quality (AHRQ) patient safety indicators (PSIs) and the Centers for Medicare and Medicaid Services hospital-acquired conditions (HACs) are publicly reported metrics used to gauge the quality of health care provided by health care institutions. To better understand the prevalence of these events in hospitalized patients treated for ruptured cerebral aneurysms, the authors determined the incidence rates of PSIs and HACs among patients with a diagnosis of subarachnoid hemorrhage and procedure codes for either coiling or clipping in the Nationwide Inpatient Sample database.

Methods
The authors queried the Nationwide Inpatient Sample database, part of the AHRQ's Healthcare Cost and Utilization Project, for all hospitalizations between 2002 and 2010 involving coiling or clipping of ruptured cerebral aneurysms. The incidence rate of each PSI and HAC was determined by searching the hospital records for ICD-9 codes. The authors used the SAS statistical software package to calculate incidence rates and perform multivariate analyses to determine the effects of patient variables on the probability of developing each indicator.

Results
There were 62,972 patient admissions with a diagnosis code of subarachnoid hemorrhage between the years 2002 and 2010; 10,274 (16.3%) underwent clipping and 8248 (13.1%) underwent endovascular coiling. A total of 6547 PSI and HAC events occurred within the 10,274 patients treated with clipping; at least 1 PSI or HAC occurred in 47.9% of these patients. There were 5623 total PSI and HAC events among the 8248 patients treated with coils; at least 1 PSI or HAC occurred in 51.0% of coil-treated patients. Age, sex, comorbidities, hospital size, and hospital type had statistically significant associations with indicator occurrence. Compared with patients without events, those treated by either clipping or coiling and had at least 1 PSI during their hospitalization had significantly longer lengths of stay (p < 0.001), higher hospital costs (p < 0.001), and higher in-hospital mortality rates (p < 0.001).

Conclusions
These results estimate baseline national rates of PSIs and HACs in patients treated for ruptured cerebral aneurysms. These data may be used to gauge individual institutional quality of care and patient safety metrics in comparison with national data.
Expression of heat shock proteins in medulloblastoma
Authors: Alexiou George A. , Vartholomatos George , Stefanaki Kalliopi , Patereli Amalia , Dova Lefkothea , Karamoutsios Achilleas , Lallas George , Sfakianos George , Moschovi Maria , Prodromou Neofytos 
Published: August 2013

Object
Medulloblastoma (MB) is the most common malignant brain tumor in children. Heat shock proteins (HSPs) comprise a superfamily of proteins that serve as molecular chaperones and are overexpressed in a wide range of human cancers. The purpose of the present study was to investigate the expression of HSP27 (pSer82), HSP27 (pSer15), HSP40, HSP60, HSP70, HSP90-α, Akt, and phospho-Akt by multiplex bead array assay of MBs. The results of HSP and Akt expression were correlated with MB subtype; immunohistochemical expression of Ki-67 index, bcl-2, and p53; and patients' prognosis.

Methods
The authors retrospectively evaluated 25 children with MB who underwent surgery. Immunohistochemical analysis of Ki-67, p53, and bcl-2 expression was performed in all cases. By using multiplex bead array assay, a simultaneous detection of HSP27 (pSer82), HSP27 (pSer15), HSP40, HSP60, HSP70, HSP90-α, Akt, and phospho-Akt was performed.

Results
Medulloblastoma with extensive nodularity had significantly lower HSP27 (pSer15) expression (p = 0.039) but significantly higher HSP60 expression (p = 0.021) than classic MB. Large-cell MB had significantly higher HSP70 expression (p = 0.028) than classic MB. No significant difference was found between HSP27 (pSer82), HSP40, HSP90-α, Akt, or phospho-Akt expression and MB subtype. Large-cell MBs had significantly higher Ki-67 index compared with classic MBs (p = 0.033). When analyzing all MBs, there was a significant negative correlation between HSP27 (pSer15) and Ki-67 index (r = −0.475, p = 0.016); a significant positive correlation between HSP70 expression and Ki-67 index (r = 0.407, p = 0.043); and a significant positive correlation between HSP70 expression and bcl-2 index (r = 0.491, p = 0.023). Patients with large-cell MB had a worse survival than those with classic MB, but the difference did not reach statistical significance (p = 0.076).

Conclusions
A substantial expression of several HSPs in MB was observed. Given that HSPs represent an attractive strategy for anticancer therapy, further studies, involving larger series of patients, are obviously necessary to clarify the relationship of HSPs with tumor aggressiveness and prognosis.
Une forme de villages médiévaux concentrés : le cas du Bas-Razès (Aude)
Authors: Baudreu Dominique 
Published: August 2013

Dans le centre-ouest du département de l'Aude, le Bas-Razès constitue un petit pays du piémont pyrénéen. Il appartenait à l'ancien comté de Razès dont l'histoire fut très tôt liée à celle du comté, puis de la vicomte de Carcassonne.
La description de 29 villages actuels à l'échelle du Bas-Razès fait apparaître un réseau très dense d'agglomérations compactes nées au Moyen Age. Elles sont l'illustration locale de l'incastellamento, qui entre la fin du XIe s. et le XIIIe s. est venu modifier la répartition du peuplement de la Provence à la Gascogne. Ces villages castraux présentent une forme circulaire, en général bien conservée, et étaient anciennement limités par des fossés collectifs souvent limitrophes de barris.
Les surfaces des enceintes sont dans les deux-tiers des cas de faible importance (inférieures ou égales à 5.000 m2). Le peuplement villageois s'est organisé autour d'un château aujourd'hui disparu mais aussi plus rarement autour d'une église.
Les mentions textuelles donnent quelques indications sur le peuplement pré-castral encore largement méconnu et laisse en grande partie dans l'ombre la gestation des nouvelles agglomérations. Ici comme dans d'autres régions, l'encel- lulement des hommes est la résultante matérielle des nouvelles structures socio-politiques apparues au XIe s.
Le rôle géo-politique du castrum d'Alaigne, chef-lieu actuel de canton, a dû être déterminant tout au long du Moyen Age. Il semble avoir été jusqu'au XIIe s. le siège d'une petite vicomte.
A la fin du Moyen Age, ce sont les enceintes collectives qui tiennent lieu de défense principale au détriment des châteaux seigneuriaux primitifs (sauf dans les rares cas où ils ont pu être transformés en forts collectifs).
Recherches archéologiques sur le site de l'église de Saint-Martin de Celle, Maubourguet (Hautes-Pyrénées)
Authors: Doussau Sylvain 
Published: August 2013

Au milieu de la plaine de Bigorre, la ville de Maubourguet possède une église paroissiale romane, Saint-Martin, dont l'intérêt a depuis longtemps été reconnu par les historiens de l'art. Cet édifice avait fait l'objet de quelques sondages archéologiques pratiqués alentour et qui permettaient de supposer une occupation du site bien antérieure au Moyen Age.
En 1983 et 1984 l'église de Maubourguet a été fermée au culte dans le cadre d'un programme de restauration des Monuments Historiques. Une équipe d'archéologues bénévoles a su profiter de cette opportunité pour fouiller partiellement et avec des moyens limités le sous-sol de l'église. Cette recherche, organisée en sondages, a permis effectivement de mettre en évidence une continuité d'occupation depuis l'Antiquité. La découverte d'une église paléochrétienne à nef unique et chevet pentagonal, bâtie sur les vestiges d'un important édifice antique semble attester la christianisation d'un vicus. A cet édifice de dimensions modestes a succédé une église carolingienne à chevet semi-circulaire et transept, qui marque la présence d'une communauté religieuse. Celle-ci conduira à la fondation, au XIe siècle, en ce même lieu, du prieuré bénédictin Saint-Martin de Celle. L'église du XIe siècle à trois absides et nef unique sera agrandie au XIIe siècle par l'adjonction de collatéraux.