bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Association between Serum Follistatin-like Proteins and Cardiovascular
Diseases: A Systematic Review and Meta-analysis
Authors: Ahmadzadeh Amir Mahmoud , Khodashahi Rozita , Shabestari Mahmoud Mohamadzadeh , Aliakbarian Mohsen , Sahebkar Amirhossein , Arjmand Mohammad-Hassan 
Published: July 2024

Background:
Follistatin-like proteins (FSTLs) are adipomyokines secreted by adipocytes and myocytes. Previous studies have reported an increase in circulating FSTL1 levels in
response to cardiovascular injuries. In this study, we conducted a systematic review and metaanalysis to assess the association between circulating FSTLs and Cardiovascular Diseases
(CVDs).

Methods:
We performed a comprehensive literature search using PubMed, Web of Science,
Scopus, and Embase databases. After screening the articles, we selected eligible studies, extracted relevant data, and calculated the pooled Standardized Mean Difference (SMD). We also conducted a sensitivity analysis to identify sources of heterogeneity and assessed publication bias.

Results:
Among the 577 articles initially retrieved, we included 5 studies comprising a total of
941 cases with CVDs and 446 controls. All included studies measured FSTL1 levels. The
pooled SMD analysis revealed a significant difference in circulating FSTL1 levels between subjects with CVDs and control groups (SMD = 0.853, 95% CI = 0.158-1.548, P = 0.016). Heterogeneity was primarily attributed to a single study that measured FSTL1 levels in heart failure patients with preserved ejection fraction. No publication bias was observed.

Conclusion:
Our findings demonstrate significantly higher levels of FSTL1 in patients with
CVD compared to control subjects. This suggests that FSTL1 may have potential as a diagnostic
and prognostic biomarker in CVDs. However, further well-designed studies are needed to validate its clinical utility.
Using Biosensor Devices and Ecological Momentary Assessment to Measure Emotion Regulation Processes: Pilot Observational Study With Dialectical Behavior Therapy
Authors: Rizvi Shireen L , Ruork Allison K , Yin Qingqing , Yeager April , Taylor Madison E , Kleiman Evan M 
Published: July 2024

Abstract

Background
Novel technologies, such as ecological momentary assessment (EMA) and wearable biosensor wristwatches, are increasingly being used to assess outcomes and mechanisms of change in psychological treatments. However, there is still a dearth of information on the feasibility and acceptability of these technologies and whether they can be reliably used to measure variables of interest.

Objective
Our objectives were to assess the feasibility and acceptability of incorporating these technologies into dialectical behavior therapy and conduct a pilot evaluation of whether these technologies can be used to assess emotion regulation processes and associated problems over the course of treatment.

Methods
A total of 20 adults with borderline personality disorder were enrolled in a 6-month course of dialectical behavior therapy. For 1 week out of every treatment month, participants were asked to complete EMA 6 times a day and to wear a biosensor watch. Each EMA assessment included measures of several negative affect and suicidal thinking, among other items. We used multilevel correlations to assess the contemporaneous association between electrodermal activity and 11 negative emotional states reported via EMA. A multilevel regression was conducted in which changes in composite ratings of suicidal thinking were regressed onto changes in negative affect.

Results
On average, participants completed 54.39% (SD 33.1%) of all EMA (range 4.7%‐92.4%). They also wore the device for an average of 9.52 (SD 6.47) hours per day and for 92.6% of all days. Importantly, no associations were found between emotional state and electrodermal activity, whether examining a composite of all high-arousal negative emotions or individual emotional states (within-person r ranged from −0.026 to −0.109). Smaller changes in negative affect composite scores were associated with greater suicidal thinking ratings at the subsequent timepoint, beyond the effect of suicidal thinking at the initial timepoint.

Conclusions
Results indicated moderate overall compliance with EMA and wearing the watch; however, there was no concurrence between EMA and wristwatch data on emotions. This pilot study raises questions about the reliability and validity of these technologies incorporated into treatment studies to evaluate emotion regulation mechanisms.
Association between Chronic Kidney Disease-Mineral and Bone Disorder Biomarkers and Symptom Burden in Older Patients with Advanced Chronic Kidney Disease
Authors: Magagnoli Lorenza , Cozzolino Mario , Evans Marie , Caskey Fergus J. , Dekker Friedo W. , Torino Claudia , Szymczak Maciej , Drechsler Christiane , Pippias Maria , Vilasi Antonio , Janse Roemer J. , Krajewska Magdalena , Stel Vianda S. , Jager Kitty J. , Chesnaye Nicholas C. ,   the EQUAL study investigators
Published: July 2024

Key Points

In nondialysis patients with advanced CKD, mild-to-moderately increased parathyroid hormone is associated with lower levels of reported symptoms.Phosphate and calcium are not independently associated with overall symptom burden.Patients with both severe hyperphosphatemia and severe hyperparathyroidism had the highest symptom burden.

Background
Patients with advanced CKD develop numerous symptoms, with a multifactorial origin. Evidence linking mineral disorders (CKD-Mineral and Bone Disorder) and uremic symptoms is scant and mostly limited to dialysis patients. Here, we aim to assess the association between CKD-Mineral and Bone Disorder and symptom burden in nondialysis patients with CKD.

Methods
We used data from the European Quality study, which includes patients aged ≥65 years with eGFR ≤20 ml/min per 1.73 m2 from six European countries, followed up to 5 years. We used generalized linear mixed-effect models to determine the association between repeated measurements of parathyroid hormone (PTH), phosphate, and calcium with the overall symptom number (0–33), the overall symptom severity (0–165), and the presence of 33 CKD-related symptoms. We also analyzed subgroups by sex, age, and diabetes mellitus and assessed effect mediation and joint effects between mineral biomarkers.

Results
The 1396 patients included in the study had a mean of 13±6 symptoms at baseline, with a median overall severity score of 32 (interquartile range, 19–50). The association between PTH levels and symptom burden appeared U-shaped with a lower symptom burden found for mild-to-moderately increased PTH levels. Phosphate and calcium were not independently associated with overall symptom burden. The highest symptom burden was found in patients with a combination of both severe hyperparathyroidism and severe hyperphosphatemia (+2.44 symptoms [0.50–4.38], P = 0.01). The association of both hypocalcemia and hyperphosphatemia with symptom burden seemed to differ by sex and age.

Conclusions
In older patients with advanced CKD not on dialysis, mild-to-moderately increased PTH was associated with a lower symptom burden, although the effect size was relatively small (less than one symptom). Neither phosphate nor calcium were associated with the overall symptom burden, except for the combination of severe hyperphosphatemia and severe hyperparathyroidism which was associated with an increased number of symptoms.
Weakly Orthogonally Additive Functionals on Mcshane-Bochner Integral Function Spaces Defined in Euclidean Spaces Rn
Authors: Riyadi  
Published: July 2024

The study of weakly orthogonal additive functions impacts the structural properties of a function space and allows further investigation into the solution of broader mathematical problems. The aim of this research is to analyze the properties and application of weak orthogonal additive functions on the McShane-Bochner integral function space defined in Euclidean space. . The research method used is Research and Development (R&D). This type of research is descriptive qualitative. Population in this study is Vectors in Euclidean Space RN\mathbb{R}^NRN: This research begins by conducting a preliminary analysis through literature study, then testing the theory, carrying out evaluations, and drawing conclusions. After that the theory that had been developed was tested through Focus Group Discussion activities. This research succeeded in building a function space which is a collection of McShane-Bochner integral functions defined in cells. in Euclidean space that meets certain characteristics. Based on this function space, the Representation Theorem for weakly orthogonal additive functions is then constructed in the newly constructed function space. The implication of this research is that this research enriches understanding of the structure and properties of McShane-Bochner integrable functions, which is an important generalization in functional analysis and integration theory.
Expressions of the Concept of the Verb ‘To Go’ in Udihe: Polysemy and Directions of Metaphorical Transfers
Authors: Сагайдачная Анна Олеговна 
Published: July 2024

Предлагаемая работа посвящена описанию способов выражения понятия «идти» в удэгейском языке. Проанализировав около 80 глаголов с семантикой хождения, делаем вывод, что данное понятие выражается в языке двумя основными средствами – с помощью словообразования и лексически. Словообразовательный суффикс -на-, имеющий значение ʻидти с какой-либо целью куда-либоʼ, присоединяется к глаголам разных лексико-семантических групп, переводя эти глаголы в лексико-семантическую группу «идти» (улэнэ- ʻидти копатьʼ, гуӈнэ- ʻидти сказатьʼ и др.). Важной чертой является и лексическое многообразие глаголов, обозначающих не только общие, но и более конкретные виды хождения (эмэ- ʻприходитьʼ, уǯаʻидти по следу зверяʼ, аӈанаги- ʻидти обратноʼ и др.). Кроме того, рассмотрены некоторые глаголы, переносное значение которых соотносится с понятием «идти» (њухана- ʻнырятьʼ, эдинэ- ʻдуть ветруʼ и др.). Данное исследование опирается на работы, посвященные родственным тунгусо-маньчжурским языкам, – маньчжурскому, нанайскому, эвенкийскому, орокскому и орочскому. Также привлечен материал как типологически сходных с удэгейским самодийских и тюркских языков – ненецкого, тувинского, хакасского, алтайского, так и типологически отличных от удэгейского славянских и германских языков – русского, английского.
This article was written according to the author’s report in September 2023 at the Tomsk State Pedagogical University at the international conference “XXX Dulson Readings”. This work describes how to express the concept of the verb ‘to go’ in Udihe. After analyzing about 80 verbs meaning ‘to go,’ we have concluded that this verb is expressed in the language in two basic ways – lexically and derivationally. The derivational suffix -nawith the semantic purpose of the movement is attached to the verbs of different lexical-semantic groups and transfers these verbs into the lexical-semantic group ‘to go’ (ulene- ʻto go digʼ, guŋne- ʻto go say something). An important feature is the lexical diversity of the verbs, which denote not only general but also specific types of the verb ‘to go’ (eme- ʻto comeʼ, uǯa- ʻto follow the track of an animal, aŋanagi- ʻto go backʼ). In addition, this paper discusses several verbs whose figurative meaning correlates with the concept of the verb ‘to go’ (ñuhana- ʻdiveʼ, edine- ʻblow windʼ). This study is based on the work devoted to the related Manchu-Tungusic languages – Manchurian, Nanay, Evenki, Oroch, and Orok (Uilta). The material of the Samoyed and Turkic languages that are typologically similar to Udihe – Nenets, Tuvan, Altai, and Khakass – is also of interest. In addition, the material of the Slavic and Germanic languages that are typologically different from Udihe – Russian and English – is also involved in the study.
SISTEM INFORMASI PRESTASI SISWA BERBASIS WEBSITE PADA SMP NEGERI 5 METRO
Authors: Rudi Rudi Samsuriyawan , Anggoro Dani , Siregar Guna Yanti Kemala Sari 
Published: July 2024

Abstrak: SMP Negeri 5 Metro merupakan salah satu Lembaga pendidikan yang berlokasi di Metro Selatan, Lampung. Berdasarkan pengamatan serta wawancara yang dilakukan oleh penulis dengan pihak sekolah, adanya masalah dalam pengelolaan serta pencatatan prestasi siswa karena masih dilakukan secara manual sehingga data sering hilang dan sekolah tidak dapat melakukan monitor prestasi siswa. Tujuan penelitian ini adalah merancang sistem informasi berbasis website pada SMP Negeri 5 Metro untuk mempublikasi prestasi dan monitoring prestasi. Metode yang digunakan dalam penelitian ini adalah System Development Life Cycle (SDLC) dengan pengujian menggunakkan Black Box Testing. Hasil dari penelitian ini adalah sebuah website dengan berbagai fitur yang dapat memudahkan pendataan siswa beprestasi baik di bidang akademik dan non akademik, pencarian siswa berprestasi, mencetak data siswa, dan menampilkan jenis prestasi yang telah diraih siswa. Adapun kekurangan dalam website ini adalah penggantian password masih dilakukan secara manual. Penulis berharap agar peneliti selanjutnya dapat memperbaiki kekurangan tersebut.
Kata kunci : Sistem Informasi, Website, SDLC

ABSTRACT: Junior High School 5 Metro is an educational institution located in South Metro, Lampung. Based on observations and interviews conducted by the author with the school, there are problems in managing and recording student achievement because it is still done manually so data is often lost and schools cannot monitor student achievement. The purpose of this study was to design a website-based information system at Junior High School 5 Metro to publish achievements and monitor achievements. The method used in this research is the System Development Life Cycle (SDLC) with testing using Black Box Testing. The result of this study is a website with various features that can facilitate data collection of outstanding students in both academic and non-academic fields, achievement, print student data, and display the types of achievements that have been achieved by students. The drawback in this website is that password changes are still done manually. The author hopes that future researchers can correct these shortcomings.

Keywords: Information System, Website, SDLC
the Implementasi Metode Prototipe Dalam Perancangan E-Commerce Toko Fikri Koleksi
Authors: Handayani Febria Sri , Elena Magris , Putra Agung Pratama 
Published: July 2024

Toko Fikri Koleksi bergerak dibidang penjualan kerajinan daerah sekaligus rumah industri pengrajin kain tenun songket, jumputan, blongsong atau tajung, baju batik songket dan cenderamata berupa souvenir khas Palembang. Proses jual beli di Toko Fikri Koleksi masih dilakukan secara konvensional dan kurang memanfaatkan sistem penjualan secara digital / online ataupun e-commerce. Hal ini menimbulkan kesulitan dalam menjangkau pangsa pasar di luar daerah. Selain itu upaya promosi di media sosial juga kurang optimal. Pihak manajemen toko juga harus berupaya untuk mengatur strategi bertahan ditengah banyaknya pesaing bisnis yang menjual barang sejenis di sekitar Toko. Perancangan web e-commerce bagi toko Fikri Koleksi dinilai dapat membantu dalam mendukung aktivitas promosi dan penjualan produk di Toko Fikri Koleksi secara online. Selain itu dapat memudahkan konsumen melakukan transaksi secara online. Metode perancangan sistem yang digunakan yaitu metode prototype, dan alat perancangan sistem menggunakan Activity Diagram, Use Case Diagram, dan Class Diagram. Pengujian sistem menggunakan teknik equivalence partitioning dan sistem yang dibangun diuji usabilitasnya menggunakan pengujian system usability scale (SUS). Penelitian ini menghasilkan dan telah mengimplementasikan sebuah website e-commerce yang dapat mengelola data pesanan, menghasilkan informasi berupa laporan penjualan, laporan stok dan laporan pesanan.
PEMBERIAN KREDIT DENGAN MENGGUNAKAN METODE ANALYTIC HIERARCHY PROCESS (AHP) PADA PERBANKAN
Authors: Asmanto Budi 
Published: July 2024

Abstrak
Meningkatkan kualitas kredit dan mengurangi pemberian kredit yang bermasalah, diselenggarakan melalui pendekatan kepada calon debitur, peningkatan pengetahuan petugas bank, pencegahan peyalah gunaan dana kredit, pembinaan terhadap calon debitur, dan kesadaran debitur untuk menangsur kredit tepat waktu, yang dilaksanakan secara menyeluruh, terpadu, dan berkesinambungan.
Proses evaluasi memerlukan suatu metoda yang dapat memudahkan penilaian dan pengambilan keputusan, karena dalam pengambilan keputusan berhubungan dengan kriteria-kriteria dan banyaknya alternatif debitur, maka perlu digunakan suatu teknik penilaian yang efektif dan tidak terlalu kompleks, tetapi memberikan hasil yang akurat. Evaluasi ini juga melibatkan penilaian dari pihak manajemen perbankant atau pihak yang terkait dengan debitur sehingga ketepatan penilaian yang diberikan oleh tiap-tiap responden sangatlah penting.
AHP merupakan suatu metoda untuk membuat ranking alternative keputusan dalam memilih salah satu yang terbaik ketika pembuat keputusan dan memiliki macam kriteria. Pada metode AHP pembuatan hirarki digunakan untuk menguraikan permasalahan menjadi bagian yang lebih terkecil. Hirarki terdiri dari beberapa tingkat, yaitu tujuan, kriteria, sub kriteria dan altervative.

Kata kunci : kualitas kredit1, evaluasi para debitur kredit2, Analytic Hierarchy Process (AHP)3

Abstract

Improving credit quality and reducing non-performing loans, implemented through approaches to prospective debtors, increased knowledge of bank officers, prevention of misuse of credit funds, guidance to prospective debtors, and awareness of debtors to repay loans on time, which is carried out in a comprehensive, integrated, and sustainable.
The evaluation process requires a method that can facilitate assessment and decision making, because in making decisions related to the criteria and the number of alternative debtors, it is necessary to use an assessment technique that is effective and not too complex, but provides accurate results. This evaluation also involves an assessment from the banking management or parties related to the debtor so that the accuracy of the assessment given by each respondent is very important.
AHP is a method for ranking decision alternatives in choosing the best one when making decisions and having various criteria. In the AHP method, a hierarchy is used to break down the problem into smaller parts. The hierarchy consists of several levels, namely objectives, criteria, sub-criteria and alternatives.

Keywords: credit quality1, evaluation of credit debtors2, Analytic Hierarchy Process (AHP)3.
Analisis Sistem Inventaris Gudang Baju PT PQR dengan Pendekatan Analisis Desain Berbasis Objek
Authors: Kurniawan Arya , Garibaldi Muhammad Adib , Kautsar Rahagi , Darwis Muhammad , Hendrowati Retno 
Published: July 2024

PT PQR adalah perusahaan yang bergerak di bidang bisnis pakaian. Salah satu masalah yang sering dihadapi oleh perusahaan tersebut adalah terjadinya kesalahan pencatatan jumlah stok pada gudang-gudang milik perusahaan tersebut yang mengakibatkan banyak data yang duplikat dan kerugian yang cukup besar. Untuk mengatasi hal tersebut, PT PQR perlu memanfaatkan aplikasi dalam pengelolaan barang mereka. Oleh karena itu, penulis mengembangkan aplikasi inventaris pada PT PQR dengan menggunakan pendekatan berorientasi objek. Perancangan aplikasi menggunakan UML yang terdiri dari use case diagram, activity diagram, dan class diagram. Proses implementasi aplikasi memanfaatkan framework Laravel dan database MySQL dengan tetap fokus pada objek. Hasil aplikasi pada penelitian ini telah diuji dengan metode black box dan menunjukkan keberhasilan seluruh fungsionalitas telah tercapai.
PENERAPAN MANAJEMEN BANDWIDTH DENGAN ROUTER MIKROTIK PADA BALAI DESA TANGGULANGIN KECAMATAN PUNGGUR
Authors: Nugroho Zullul Makmun , Hidayat Arif , Wulandari Ika Arthalia 
Published: July 2024

Abstrak : Balai Desa Tanggulangin tempat berkumpul dan bermusyawarah masyarakat. Selain itu pegawai, staff dan anak magang juga melakukan pekerjaan atau tugas di balai desa yang tentunya tidak lepas dari penggunaan internet. Maka dari itu internet menjadi sangat lambat ketika ketika melakukan semua aktivitas bersamaan dan belum ada pengelolaan bandwidth internet. Tujuan dari penelitian ini adalah untuk menerapkan manajemen bandwidth untuk pengguna internet balai desa tanggulangin. Metode yang digunakan adalah NDLC(Network Development Life Cycle) dengan tahapan yaitu Analysis, Design, Simulation Prototyping, Implementation, Monitoring, Management. Hasil penelitian ini adalah Penerapan Manajemen Bandwidth menggunakan Route Mikrotik dan Access Point sebgaia hardware. Dengan Software Winbox dan metode Simple Queue kecepatan yang awalnya 40Mbps dapat dibagi menjadi 20Mbps untuk Lan-komputer dan 20Mbps untuk wifi. Adanya manajemen bandwidth membantu pengguna pengguna internet pada balai desa Tanggulangin dengan lebih stabil.

Kata Kunci : Balai Desa; Bandwidth; NDLC; Simple Queue.
Abstract: Tanggulangin Village Hall is a place for community gathering and deliberation. Apart from that, employees, staff and interns also carry out work or tasks at the village hall which of course cannot be separated from the use of the internet. Therefore, the internet becomes very slow when all activities are carried out simultaneously and there is no internet bandwidth management. The aim of this research is to implement bandwidth management for Tanggulangin village hall internet users. The method used is NDLC (Network Development Life Cycle) with stages namely Analysis, Design, Simulation Prototyping, Implementation, Monitoring, Management. The result of this research is the implementation of Bandwidth Management using Mikrotik Routes and Access Points as hardware. With Winbox software and the Simple Queue method, the initial speed of 40Mbps can be divided into 20Mbps for computer Lan and 20Mbps for WiFi. The existence of bandwidth management helps internet users at the Tanggulangin village hall more stably..

Keywords: Village Hall; Bandwidth; NDLC; Simple Queue
Meningkatkan Keaktifan Belajar Siswa dengan Menerapkan Lesson Study
Authors: Cantika Riana Puspa 
Published: July 2024

Penelitian dilakukan untuk meningkatkan keaktifan belajar siswa dalam pembelajaran IPA dengan menerapkan lesson study. Metode penelitian yang digunakan yaitu metode kuantitatif deskriptif. Populasi dalam penelitian ini adalah siswa kelas VII.3 SMP Islam Al Falah Jambi dengan sampel yang berjumlah 25 siswa, yaitu 12 siswa perempuan dan 13 siswa laki-laki yang dipilih dengan teknik non-probability sampling. Upaya yang dilakukan dalam penelitian ini dengan menerapkan lesson study dengan tiga tahapan yaitu, perencanaan, pelaksanaan, dan refleksi. Pengumpulan data pada penelitian ini menggunakan observasi, dokumentasi, dan lembar observasi keaktifan belajar siswa yang dilakukan sebanyak 2 siklus lesson study. Adapun hasil yang diperoleh pada siklus 1 yaitu keaktifan fisik berada pada kategori cukup, keaktifan intelektual dan mental pada kategori kurang, serta keaktifan emosional pada kategori baik. Pada siklus 2 terjadi peningkatan yaitu keaktifan fisik dan emosional berada pada kategori sangat baik, keaktifan intelektual dan mental berada pada kategori baik. Berpijak dari hasil penelitian dapat disimpulkan bahwa dengan menerapkan lesson study dalam pembelajaran dapat meningkatkan keaktifan belajar siswa. Hal itu terbukti dari adanya peningkatan dari masing-masing indikator keaktifan belajar yang ada.