bluuebunny/crossref_metadata_2025_split huggingface dataset:
Navigating COVID-19-associated mucormycosis: endoscopic grading, radiological correlations, and treatment outcomes
Authors: Gupta Yamini , Verma Jagram , Valecha Krishna 
Published: June 2024

Abstract
Background
The global COVID-19 pandemic has brought forth multifaceted healthcare challenges, including the emergence of COVID-19-associated mucormycosis (CAM). This study investigates demographics, clinical presentation, endoscopic grading, radiological correlations, treatment modalities, and outcomes of CAM in Central India.

Methods
A retrospective analysis of 312 CAM patients (April-June 2021). Data included demographics, clinical profiles, endoscopic and radiological findings, laboratory results, and treatments. A novel endoscopic grading system was utilized to assess the severity of mucormycosis lesions. Statistical analysis, including chi-squared tests, was performed.

Results
Among 312 patients, 65% were male, 82% had comorbidities, and 84% presented with facial swelling. Endoscopic grading correlated with radiological manifestations (p < 0.05) and intraoperative findings. Surgical debridement and antifungal therapy were common treatments, yielding varied clinical outcomes. Mortality was 13% in advanced grades.

Conclusion
This study underscores the role of endoscopic grading in risk stratification and prognosis. Findings contribute to CAM management knowledge, underscoring tailored interventions’ significance.
Characterization of pepper (
Capsicum
spp.) germplasms based on morphological and phytochemical characters in Bangladesh
Authors: Parvin Nighat , Masuda Mst Salma , Turin Mst Tanjina Shahanaj , Jui Sohana , Amzad Mst. Anamika , Khatun Mst. Ananya , Arifuzzaman Md , Alshamrani Rahma Ibrahim , Ahmed Eakhlas Uddin 
Published: June 2024

Abstract

Pepper (
Capsicum
spp.) is a major spice crop around the globe. The major goal of the experiment was to evaluate the genetic diversity amongst 30 pepper germplasms for twelve morphological and phytochemical parameters. The investigation was conducted between November 2019 and April 2020 using a randomized complete block design with three replications in the experimental field of Hajee Mohammad Danesh Science and Technology University, Dinajpur, Bangladesh. The results revealed a notable disparity across the genotypes for all studied traits. The genotype C80 displayed the highest fresh fruit weight (20.60 g) and dry fruit weight (1.20 g). Once again, the genotype YF1 had the highest chlorophyll and vitamin-C contents. The most significant correlations were revealed between fresh fruit weight and dry fruit weight (r = 0.83***) followed by between fruit diameter and dry fruit weight (r = 0.80***), and between fruit diameter and fresh fruit weight (r = 0.79***). The Wards-D method was used to cluster thirty genotypes into four clusters based on Euclidean distances. Cluster IV consisted of a maximum of 13 pepper genotypes. Cluster I yielded the greatest fresh fruit weight, measuring 11.75 g, whereas cluster III contained the highest Vitamin-C content, measuring 23.61 mg/ 100 g. The clusters I and III had the highest inter-cluster distances (6.45), while cluster I had the highest intra-cluster distance (2.36). PC1 and PC2 explained 32.8% and 18.3% of the total variances, respectively. In the biplot, the genotypes C54 and C80 favored fresh and dry fruit weights as well as fruit diameters, while the genotypes C29 and YF1 positively favored chlorophyll and vitamin-C contents. Therefore, the diverse pepper genotypes C54, C80 from cluster I and C29 and YF1 from cluster III could be included in future hybridization of pepper breeding.
The qP- and qSV-wave separation in 2D vertically transversely isotropic media and their applications in elastic reverse time migration
Authors: Fan Na , Xie Xiao-Bi , Zhao Lian-Feng , Yao Zhen-Xing 
Published: June 2024

Compressional and shear wave separation is an important step in anisotropic elastic reverse time migration (ERTM). With separated wavefields, we can generate images between different wave types and reveal more subsurface physical properties, as well as remove unwanted crosstalk and improve image quality. Traditional Helmholtz decomposition based on divergence and curl operations for isotropic media cannot be directly extended to vertically transversely isotropic (VTI) media. Wave-mode separation methods, similar to the nonstationary spatial filter and Poynting vector, cannot preserve the phase and amplitude information of the original coupled wavefield, thus limiting their application in ERTM. Currently, the anisotropic wavefield decomposition methods include the wavenumber-domain approach, the low-rank approximation, and other separation approaches based on different approximations, e.g., weak or elliptical anisotropy. These methods are either computationally intensive or involve large separation errors, especially in models with strong heterogeneities and anisotropy. The VTI wavefield separation operator is essentially defined in a mixed space-wavenumber domain. We introduce scalar operators to transfer operations from this mixed space-wavenumber domain to the space domain. The local wave propagation direction in the scalar operators is estimated using the Poynting vector, which is highly computationally efficient in the space domain. When we apply the wave separation method to ERTM, we not only obtain the vectorized qP and qSV waves but also retrieve the scalar qP wavefield. The scalar and vector wavefields preserve the amplitude and phase information in the original coupled wavefield. For anisotropic ERTM, we suggest using the scalar imaging condition to generate the PP image and the magnitude- and sign-based vector imaging condition to produce the PS image, both having higher image accuracy than the dot-product imaging condition. Numerical examples are used to validate our anisotropic wavefield separation method and the related ERTM workflow.
Impact of complete cytogenetic response on survival in patients with myelodysplastic syndromes.
Authors: Urrutia Samuel , Sasaki Koji , Kantarjian Hagop M. , Jabbour Elias , Chien Kelly Sharon , Hammond Danielle , Bueso-Ramos Carlos E. , Khoury Joseph , Patel Keyur P. , Montalban-Bravo Guillermo , Wei Yue , Colla Simona , Short Nicholas James , Daver Naval Guastad , Borthakur Gautam , Kadia Tapan M. , Pierce Sherry , Wierda William G. , Garcia-Manero Guillermo 
Published: June 2024

6567 Background: Response to therapy prolongs survival in patients with myelodysplastic syndromes (MDS). The aim of this study is to evaluate the impact of complete cytogenetic response (CCyR) on survival in patients with MDS and abnormal cytogenetics. Methods: We reviewed 2311 consecutive patients with MDS and cytogenetic abnormalities who were treated at our institution from 2006 to 2023. Results: CCyR was observed in 330 patients (14%), complete response (CR) in 208 (9%), CR with bilineage recovery (CRbi) in 255 (11%), CR with unilineage recovery (CRuni) in 151 (7%), CR with incomplete hematologic recovery (CRh) in 4 (0.2%), and non-CR in 1363 (59%). With a median follow-up of 59 months, the median overall survival (mOS) was 14 months. Ten months for non-CR, 19 months for CRh/CRbi/CRuni, 21 months for CR, and 26 months for patients with CCyR (p < 0.001). With stem cell transplant (SCT) censoring, mOS was 15 months. Eleven months in non-CR, 19 months in CRh/CRbi/CRuni, 19 months in CR, and 27 months for patients with CCyR (p < 0.001). In low-risk MDS by the International Prognostic Scoring System (IPSS), mOS with SCT censoring was 87 months for CCyR, compared to 40 months for non-CR, 38 months for CRh/CRbi/CRuni, and 36 months for CR (p < 0.001). In intermediate/high-risk MDS mOS with SCT censoring mOS was 25 months in CCyR, compared to 9 months in non-CR, 15 months in CRh/CRbi/CRuni, and 17 months in CR (p < 0.001). In a multivariate regression analysis, age > 75 years (HR 3.1, p < 0.001), complex karyotype (HR 2.15, p < 0.001) performance status 3-4 (HR 1.48, p < 0.001), hemoglobin < 8 g/dL (HR 1.48, p=0.003), creatinine > 1.3 g/dL (HR 1.44, p < 0.001), therapy-related AML (HR 1.41, p < 0.001), infection at diagnosis (HR 1.34, p =0.003), white blood cells > 50 x109/L (HR 1.31, p <0.001), cardiac comorbidities (HR 1.26, p < 0.001), platelets < 20 x109/L (HR 1.26, p=0.001), pneumonia at diagnosis (1.22, p =0.006), and core-binding factor cytogenetics (HR 0.48, p < 0.001) were independently prognostic for survival in this select group. Conclusions: Achievement of CCyR in patients with MDS and abnormal cytogenetic abnormalities leads to improved survival. Given poor outcomes in older patients with MDS, CCyR can be used as a valid surrogate for long-term outcomes.
J-TAIL-2: A prospective observational study of atezolizumab (atezo) combination therapy in patients (pts) with non-small cell lung cancer (NSCLC) in Japan.
Authors: Watanabe Yasutaka , Nishio Makoto , Ohashi Kadoaki , Osoegawa Atsushi , Kikuchi Eiki , Kimura Hideharu , Goto Yasushi , Shimizu Junichi , Miyauchi Eisaku , Yoshioka Hiroshige , Yoshino Ichiro , Misumi Toshihiro , Yamaguchi Masafumi , Yoshimori Kouzou , Seike Masahiro , Yoshida Hironori , Nishino Kazumi , Miwa Asako , Tanaka Misa , Gemma Akihiko 
Published: June 2024

8573 Background: The IMpower130 (West et al. Lancet Oncol 2018), IMpower132 (Nishio et al. JTO 2021) and IMpower150 (1) trials led to the approval of first-line atezo combination therapies for NSCLC. As data remain limited in Japanese pts, J-TAIL-2 (NCT04501497) is evaluating the efficacy and safety of 3 atezo combination therapies for NSCLC in the clinical setting in Japan. Methods: Japanese pts had unresectable advanced or recurrent NSCLC, were ≥20 y old, and were scheduled to start atezo combination therapy in clinical practice. Pts received atezo + carboplatin and nab-paclitaxel (atezo + CnP), atezo + carboplatin or cisplatin + pemetrexed (atezo + PP) or atezo + bevacizumab + carboplatin + paclitaxel (atezo + bev + CP). The primary endpoint was 12-mo OS rate. Secondary endpoints included OS and safety. Efficacy and safety were analyzed in the IMpower-unlike (did not meet the main eligibility criteria of each IMpower study) and IMpower-like subgroups. Geriatric assessment (G8) was done in pts ≥70 y old at baseline; a score < median vs ≥ median indicated poorer health status. Results: From Aug 21, 2020, to data cut off (Feb 3, 2023), 814 pts were enrolled at 150 sites (atezo + CnP, n=217; atezo + PP, n=211; atezo + bev + CP, n=386). Baseline characteristics in the efficacy analysis population (n=791) are shown (Table). The IMpower-unlike group included pts with ECOG PS ≥2, brain metastases or interstitial lung disease. Twelve-mo OS rates (95% CI) were 62.9% (55.8, 69.2), 72.1% (65.2, 77.9) and 68.3% (63.2, 72.9), and median OS was 19.7, 23.5 and 17.3 mo with atezo + CnP, atezo + PP and atezo + bev + CP, respectively. OS HRs (95% CI) in the IMpower-unlike vs -like subgroups were 1.36 (0.91, 2.05), 1.08 (0.70, 1.68) and 1.49 (1.09, 2.06), respectively. The median G8 score for all evaluable pts was 13; in pts with a G8 score < median vs ≥ median, OS HRs (95% CI) were 2.10 (1.22, 3.61), 3.53 (1.95, 6.37) and 2.04 (1.22, 3.40) with atezo + CnP, atezo + PP and atezo + bev + CP, respectively. In the safety analysis population (n=800), Grade ≥3 AEs occurred in 60.4% of pts and Grade 5 AEs in 1.3%. Conclusions: In Japanese pts, the efficacy and safety of each atezo combination therapy were comparable to those seen in the relevant IMpower studies and largely consistent in pts who would have been ineligible for the trials. Pts aged ≥70 y with a G8 score < median vs ≥ median had poorer efficacy and safety outcomes. 1. Socinski et al. NEJM 2018. Clinical trial information: NCT04501497 . [Table: see text]
Health insurance plans offered at NCI-designated cancer centers.
Authors: Moore Vanessa Ann , Xing Jiazhang , Bouvette Max Joseph , Lam Anh B. , Jiang Changchuan , Nipp Ryan David , Choradia Nirmal 
Published: June 2024

9052 Background: The health insurance landscape in the US represents an expensive and complex challenge to patients and physicians alike. Little is known about health insurance plans (HIPs) offered to physicians, particularly at NCI-designated cancer centers, which represent centers seeking to meet the highest standards. Methods: We collected data on the HIPs offered to physicians at NCI-designated cancer centers by reviewing institution websites from 11/2023 - 01/2024. We abstracted data on the insurance premium, deductible, out-of-pocket (OOP) maximum, and coinsurance for hospitalizations, limited to three HIPs per institution. We derived estimates using the lowest charge. We calculated inpatient stay costs based on standard hospital stay costs ($2,883 per day over an average of 4.5 days). We compared HIPs between public and private cancer centers. We used US Census Bureau population density data and regression models to explore associations among population density and OOP costs. Results: Among 65 NCI-designated cancer centers reviewed, 61 (93.8%) had readily available information about HIPs provided. Most institutions provided HIPs for all hospital employees, while 2 institutions only covered physicians. On average, each cancer center offered 3.67 HIPs, involving 1.67 insurers (54.1% offered a single insurer). Among 153 HIPs overall, 51.6% were preferred provider organization (PPOs) and one-third (33.3%) were health maintenance organization (HMOs). Only 22.9% of HIPs were high-deductible health plans (HDHP). The majority of cancer centers offered PPO plans (75.4%), HMO plans (57.4%), HDHP plans (55.7%), and some (24.6%) offered other plans, such as point of service and exclusive provider organization. Average costs for different kinds of HIPs are presented in the Table. A higher percentage of public cancer centers provided HMOs (60.5% vs. 50.0%, p=0.76) and PPOs (84.3% vs. 60.5%, p=0.09) than private centers, yet differences did not reach significance. Centers located in regions with higher state population density were more likely to have higher HMO OOP costs (beta=2.72; p=.006) and lower PPO OOP costs (beta=-2.98; p=.012). Conclusions: We found that most NCI-designated cancer centers had readily available information about HIPs provided to physicians. For these centers, physicians had limited HIP options offered, particularly in private institutions, which offered fewer HMO and PPO plans. We also demonstrated associations among state population density and OOP max in HMO and PPO plans. Our study provides a current synopsis of HIPs and identifies disparities among them, contributing to a foundation for future research. [Table: see text]
Looking Beyond the Usual Suspects: A Rare Case of Teriparatide-Induced Gynecomastia
Authors: Ramchandani Bhanvi , Mirza Faryal Sardar 
Published: June 2024

Abstract
Teriparatide, an osteoanabolic agent, is a biosynthetic analogue of the 1-34 amino acids of human parathyroid hormone (PTH) used for the treatment of osteoporosis. It is typically well-tolerated; common side effects include headaches, arthralgias, nausea, and dizziness. In this report, we present a case of gynecomastia occurring shortly after initiating teriparatide therapy, associated with nipple sensitivity and breast tenderness. Secondary workup for various causes of gynecomastia was unremarkable. Finally, a decision was made to discontinue teriparatide due to the patient’s concerns. The nipple sensitivity started improving shortly afterward, with complete resolution of gynecomastia 4 months later. Although this unusual side effect has been reported as a possibility in postmarketing studies, a chronological report on the occurrence of teriparatide-induced gynecomastia and its complete resolution after discontinuing teriparatide has not yet been published in the literature.
Cauldron, Copper, Cash: Medieval Bronze in Motion and Flux
Authors: Moser Jeffrey 
Published: June 2024

Abstract
Medieval Chinese thinkers conceptualized ancient bronzes in anthropocentric terms—as mute, inert objects that required the engagement of a perspicacious human subject for their value to become apparent. They also regarded bronzes as animate things that had the capacity to act independently of direct human manipulation, and they situated bronzes within frameworks of material vitalism that parallel many aspects of the “new materialism” associated with contemporary theorists like Karen Barad and Jane Bennett. This article interprets both of these understandings as containment strategies designed to rein in and constrain bronze's ever-present capacity for liquefaction. As with other metals, bronze was forever oscillating between solidity, in the form of discrete, functional objects, and liquidity, as a mutable substance of tremendous potency. Both states spawned different metaphors. Tracing this tension between solidity and liquidity, from the casting of the Nine Cauldrons and the origin myths of Chinese civilization through the medieval challenge of adapting a metallist currency regime to an expanding economy, this article explores how the cultural logics and natural tendencies of bronze were intertwined.
Katherine Gillen, Adrianna M. Santos, and Kathryn Vomero Santos, eds. The Bard in the Borderlands: An Anthology of Shakespeare Appropriations of Shakespeare / Appropriations en La Frontera. Vol. 1. ACMRS Press. Chicago: University of Chicago Press, 2023.
Authors: Mejia LaPerle Carol 
Published: June 2024

This review considers The Bard in the Borderlands: An Anthology of Shakespeare Appropriations of Shakespeare / Appropriations en La Frontera edited by Katherine Gillen, Adrianna M. Santos, and Kathryn Vomero Santos.
Commemorating history, historicising commemoration
Authors: Koneczniak Grzegorz 
Published: June 2024

This essay offers a combination of historical, editorial and commemorative approaches to the process of historicising the practices of remembering the Easter Rising in Ireland. Considered one of the most defining historical moments that has shaped the present-day Ireland and its relationships with Great Britain, the Easter Rebellion of 1916 was remembered in a series of events comprised within the framework of the “Decade of Centenaries” programme of celebrations. The history of the Easter Rising, spoken and unspoken, was symbolically re-enacted in various commemorative forms and via multiple media: television, radio, theatre, internet and many more cultural institutions. The study deals with crucial interconnected problems concerning the ephemerality of commemoration treated as a historical moment whose aim is to remember the defining historical event and which, paradoxically, itself becomes history. The importance of editorial and typographical considerations, as studied on the basis of selected commemorative texts and media,are important in the way in which commemoration functions and seeks unity in terms of shaping the perceptions of historical events in Ireland. Yet, the editorial, typographic and graphic dimensions of such texts may also question the discourse of practices or, at least, signal inconsistencies. The methodology applied here is that of a case study and comparative examination. Following the temporal confrontative procedure employed in one of the previous coauthored articles (see Koneczniak & Koneczniak, 2022), the research cases involve two historical moments: the analysis conducted and described during the exact commemorative moment, that is, the precise one hundredth anniversary of the Easter Rising, and the state found almost five years after the remembrance series, at the beginning of 2021. The comparative basis involves the same research materials, and it focuses on determining changes in the access to the original commemorative materials available in 2016 and linked to the celebration of the 1916 Rising.
Efficacy of a Remote Play-Based Intervention for Children With Prader-Willi Syndrome
Authors: Dimitropoulos Anastasia , Doernberg Ellen A. , Gordon Rachel A. , Vargo Kerrigan , Nichols Evelyn , Russ Sandra W. 
Published: June 2024

Abstract
The current study examines the efficacy of an 8-week pretend play intervention targeting social-cognitive abilities in children with Prader-Willi syndrome (PWS), ages 6-9. PWS is a rare disorder associated with various social, emotional, and cognitive challenges linked to pretend play impairments, and for which interventions are sparse. Nineteen children were quasi-randomized to receive the intervention or be part of a waitlist control group. Participants who received the intervention (n = 10) demonstrated significant improvements in various components of pretend play, most notably in organization of play, which may generalize to broader social-cognitive gains. These findings provide evidence of the intervention’s efficacy in enhancing pretend play skills and related social-cognitive abilities during this critical period of development for children with PWS.
Power-over-fiber-based optical wireless communication systems towards 6G
Authors: Pinto F. B. F. , Carneiro de Souza L. , Andrade T. P. V. , Lima E. S. , Silva L. G. , Portelinha F. M. , Lee Anderson E. , Cerqueira S. Arismar 
Published: June 2024

This paper reports two implementations of power-over-fiber (PoF) solutions applied to radio-over-fiber (RoF) and optical wireless communication (OWC) systems, in the context of an industrial environment. We employ a conventional 62.5-µm multimode fiber (MMF) to deliver optical power to different communication links based on RoF, free-space optics (FSO), and visible light communication (VLC) technologies aiming beyond 5G (B5G) and 6G applications. First, a 3.5-GHz 5G New Radio (5G NR) signal is transmitted throughout a 20-km single-mode optical fiber (SMF) link using RoF technology. Regarding the PoF system, a 5-W optical power is transmitted through a 100-m MMF link. A photovoltaic power converter (PPC) and a DC/DC converter are employed to convert the power from the optical to the electrical domain and adjust the voltage level, respectively, with the purpose of energizing a remote RoF module. The attainable optical and electrical power transmission efficiencies (OPTE and PTE) are 80% and 19%, respectively. Posterior, a second PoF system is implemented to power a hybrid RoF/FSO/VLC B5G system, comprising a 200-m MMF and an additional DC/DC converter. Over 10.5 W of optical power is transmitted to feed an electrical amplifier (EA) and a white LED from the VLC link. In this configuration, we achieve 78% and 18.5% of OPTE and PTE, respectively. Furthermore, a performance investigation based on the root mean square error vector magnitude (EVMRMS) metric is conducted to evaluate the signal using the implemented PoF systems and a conventional electrical power supply. In the first implementation, a throughput of 600 Mbps is achieved with 100-MHz bandwidth without performance degradation, when compared to the conventional-powered RoF system, whereas, in the second implementation, 60-Mbps throughput is achieved when employing the FSO and VLC technologies simultaneously, demonstrating the applicability and potential of the PoF technique for B5G and 6G industrial communications.