bluuebunny/crossref_metadata_2025_split huggingface dataset:
Surgery for Locally Advanced Pancreatic Cancer Following Induction Chemotherapy: A Single-Center Experience
Authors: Theijse Rutger T. , Stoop Thomas F. , Leenart Philip D. , Lutchman Kishan R. D. , Erdmann Joris I. , Daams Freek , Zonderhuis Babs M. , Festen Sebastiaan , Swijnenburg Rutger-Jan , van Gulik Thomas M. , Schoorlemmer Annuska , Sterk André L. A. , van Dieren Susan , Fariña Arantza , Voermans Rogier P. , Wilmink Johanna W. , Kazemier Geert , Busch Olivier R. , Besselink Marc G. ,   For HPB-Amsterdam
Published: July 2024

Abstract
Background
The use of surgery in patients with locally advanced pancreatic cancer (LAPC) following induction chemotherapy is increasing. However, most series do not report on the total cohort of patients undergoing surgical exploration; therefore, this single-center study investigates outcomes among all consecutive patients with LAPC who underwent surgical exploration.

Methods
We conducted a retrospective, single-center analysis including all consecutive patients with LAPC (Dutch Pancreatic Cancer Group criteria) who underwent surgical exploration with curative intent (January 2014–June 2023) after induction therapy. Primary outcomes were resection rate and overall survival (OS) from the time of diagnosis.

Results
Overall, 127 patients underwent surgical exploration for LAPC, whereby 100 patients (78.7%) underwent resection and 27 patients (21.3%) underwent a non-therapeutic laparotomy due to the extent of vascular involvement (n = 11, 8.7%) or occult metastases (n = 16, 12.6%). The overall in-hospital/30-day mortality rate was 0.8% and major morbidity was 31.3% (in patients after resection: 1.0% and 33.3%, respectively). The overall 90-day mortality rate was 5.5%, which included 3.1% mortality due to disease progression. Resection was associated with longer median OS {29 months (95% confidence interval [CI] 26–43) vs. 17 months (95% CI 11–26); p < 0.001} compared with patients undergoing non-therapeutic laparotomy, with corresponding 5-year OS rates of 28.4% and 7.7%. In Cox proportional hazard regression analysis, only pancreatic body/tail tumors independently predicted OS (hazard ratio 1.788 [95% CI 1.042–3.068]).

Conclusion
This single-center series found a resection rate of 78.7% in patients with LAPC selected for surgical exploration, with a low risk of mortality and morbidity in all explored patients and a 5-year OS rate after resection of 28.4%.
In conversation with Nancy Fraser
Authors: Fraser Nancy , Vivancos-Sánchez Carme 
Published: July 2024

Interview with US philosopher Nancy Fraser.
She links the current upsurge of protests to the broader tradition of the anti-war movement in the United States and the struggle to end the various interrelated forms of oppression on which the capitalist system is based: labour exploitation, racial oppression, imperialist oppression, oppression of women, over-exploitation and destruction of the environment.... All these forms of oppression, Fraser argues, are but different expressions of a socio-economic system based on domination and dispossession as sources of wealth.
Method for Brillouin gain spectrum recovery based on compressed sensing with convex optimization
Authors: Zhu Borong , Azad Abul Kalam , Yu Kuanglu , Ma Xiaole 
Published: July 2024

The traditional Brillouin optical fiber distributed sensors obtain the Brillouin gain spectrum (BGS) through frequency-by-frequency sweeping acquisition, which can be time-consuming and data intensive. These characteristics put a lot of pressure on data storage, especially on signal processing. Compressed sensing is a method represented by random sampling to reduce the number of acquisition frequencies, but the results obtained may be unstable. In this paper, we have proposed a reconstruction algorithm based on compressed sensing with convex optimization (COP), which can recover the whole BGS by collecting only 10% of the acquisition frequencies. The recovered BGS can attain a RMSE similar to the fully collected BGS. The proposed algorithm also provides more accurate and stable performances for different random sampling points compared to existing reconstruction methods. For example, for a 10% sampling percentage, with a reduction in error of 2.24 and 0.40 MHz, values are lower than those employing the orthogonal matching pursuit (OMP) and the regularized orthogonal matching pursuit (ROMP), respectively. Moreover, the reconstruction results of the proposed method are more stable for different random sampling points, with a reduction in standard deviation of 2.58 and 0.07 MHz.
Endothelial cell specific molecule 1 promotes epithelial-mesenchymal transition of cervical cancer via the E-box binding homeobox 1
Authors: Qi Jie , Li Jie , Zhu Xiaoyan , Zhao Sufen 
Published: July 2024

Objective
To investigate the mechanism of endothelial cell specific molecule 1 (ESM1) promoting cervical cancer cell proliferation and EMT characteristics through zinc finger E-box binding homeobox 1 (ZEB1)/EMT pathway.

Methods
The correlation between ESM1 expression and prognosis of cervical cancer patients was analyzed by bioinformatics. SiHa, HeLa cell lines and corresponding control cell lines with stable ESM1 expression were obtained. Cell proliferation ability was detected by CCK-8 assay. The invasion and migration ability of Hela and SiHa cells were detected by Transwell assay and scratch closure assay. Expressions of EMT-related markers E-cadherin and Vimentin were detected by real-time PCR. The ability of silenced ESM1 to tumor formation in vivo was detected by tumor formation in nude mice. The effects of aloe-emodin on inhibit ESM1 expression and its inhibitory effect on cervical cancer cells in vitro and in vivo were analyzed by the same method.

Results
ESM1 was highly expressed in cervical cancer, and the high expression of ESM1 was associated with poor prognosis of cervical cancer patients. CCK-8 results showed that the proliferation, invasion and migration of Hela and SiHa cells were significantly reduced after siRNA interfered with ESM1 expression. Overexpression of ESM1 promoted the proliferation and migration of cervical cancer cells. Mechanism studies have shown that the oncogenic effect of ESM1 is realized through the ZEB1/PI3K/AKT pathway. High throughput drug screening found that aloe-emodin can target ESM1. Inhibitory effect of aloe emodin on ESM1/ZEB1/EMT signaling pathway and cervical cancer cells.

Conclusion
The silencing of ESM1 expression may inhibit the proliferation, invasion, metastasis and epithelial-mesenchymal transformation of cervical cancer cells by inhibiting ZEB1/PI3K/AKT. Aloe-emodin is a potential treatment for cervical cancer, which can play an anti-tumor role by inhibiting ESM1/ZEB1.
A global perspective of advanced practice nursing research: A review of systematic reviews
Authors: Kilpatrick Kelley , Savard Isabelle , Audet Li-Anne , Costanzo Gina , Khan Mariam , Atallah Renée , Jabbour Mira , Zhou Wentao , Wheeler Kathy , Ladd Elissa , Gray Deborah C. , Henderson Colette , Spies Lori A. , McGrath Heather , Rogers Melanie 
Published: July 2024

Introduction
The World Health Organization (WHO) called for the expansion of all nursing roles, including advanced practice nurses (APNs), nurse practitioners (NPs) and clinical nurse specialists (CNSs). A clearer understanding of the impact of these roles will inform global priorities for advanced practice nursing education, research, and policy.

Objective
To identify gaps in advanced practice nursing research globally.

Materials and methods
A review of systematic reviews was conducted. We searched CINAHL, Embase, Global Health, Healthstar, PubMed, Medline, Cochrane Library, DARE, Joanna Briggs Institute EBP, and Web of Science from January 2011 onwards, with no restrictions on jurisdiction or language. Grey literature and hand searches of reference lists were undertaken. Review quality was assessed using the Critical Appraisal Skills Program (CASP). Study selection, data extraction and CASP assessments were done independently by two reviewers. We extracted study characteristics, country and outcome data. Data were summarized using narrative synthesis.

Results
We screened 5840 articles and retained 117 systematic reviews, representing 38 countries. Most CASP criteria were met. However, study selection by two reviewers was done inconsistently and language and geographical restrictions were applied. We found highly consistent evidence that APN, NP and CNS care was equal or superior to the comparator (e.g., physicians) for 29 indicator categories across a wide range of clinical settings, patient populations and acuity levels. Mixed findings were noted for quality of life, consultations, costs, emergency room visits, and health care service delivery where some studies favoured the control groups. No indicator consistently favoured the control group. There is emerging research related to Artificial Intelligence (AI).

Conclusion
There is a large body of advanced practice nursing research globally, but several WHO regions are underrepresented. Identified research gaps include AI, interprofessional team functioning, workload, and patients and families as partners in healthcare.

PROSPERO registration number
CRD42021278532.
Surgical myomectomy followed by oral Myfembree vs standard of care (SOUL trial): Study protocol for a randomized control trial
Authors: Alkhrait Samar , Al-Hendy Ayman , Alkelani Hiba , Karrison Theodore , Laveaux Obianuju Sandra Madueke 
Published: July 2024

Background
Uterine leiomyomas (often referred to as fibroids or myomas) are common benign, hormone-dependent tumors that grow in the uterus and occur in approximately 25% of reproductive age women, depending on selected population. Treatment recommendation is typically based on fibroid size, location, the patient’s age, reproductive plans, and obstetrical history. Despite the range of treatment options available for uterine fibroids and their symptoms, including hysterectomy, myomectomy, endometrial ablation, endometrial uterine artery embolization, and magnetic resonance-guided focused-ultrasound surgery, myomectomy remains the gold standard treatment for patients who desire fertility-preserving surgery for their uterine fibroids. Myomectomy, while a prevalent surgical option for the removal of fibroids, carries known risks such as fibroid recurrence, symptom recurrence, and the subsequent need for reintervention. Despite ongoing research and advances in medical treatments for fibroids, there currently are no universally recommended therapeutic interventions proven to effectively delay the recurrence of fibroids or the return of symptoms following this procedure. This situation underscores a significant area of unmet medical need and highlights the importance of continued investigation into preventive strategies and long-term management options for patients undergoing fibroid removal with uterine preservation. We designed a study to assess the efficacy of the new FDA-approved GnRH antagonist, Myfembree in delaying the return of fibroids and their associated symptoms.

Methods
A randomized, prospective, open-label clinical trial. The participants (n = 136) will be randomly distributed into two groups. The Control Group (Standard of care) will receive treatment with standard of care (SoC) after surgical myomectomy and the treatment group will receive Relugolix combination therapy (Myfembree®) after surgical myomectomy. The study protocol was approved by the University of Chicago’s Institutional Review Board (IRB#22–0282), ensuring that all participants would provide written informed consent before their inclusion.

Discussion
In this project, we propose the use of daily dosed Relugolix combination therapy (Relugolix with estradiol and norethindrone acetate), which is approved for uterine fibroids treatment, has the potential to delay the recurrence of fibroid symptoms, prolong the improved quality of life and delay need for re-intervention after uterine sparing surgery.

Trial registration
The study protocol was approved by the Institutional Review Board of the University of Chicago on 9/16/2022 and was registered at ClinicalTrials.gov with number NCT05538689 on Sep 7, 2022. All subjects will provide informed consent to participate.
Clinical characteristics and factors associated with long COVID among post-acute COVID-19 clinic patients in Zambia, August 2020 to January 2023: A cross-sectional and longitudinal study design
Authors: Malambo Warren , Chanda Duncan , Besa Lily , Engamba Daniella , Mwiinga Linos , Mwitumwa Mundia , Matibula Peter , Naik Neil , Sivile Suilanji , Agolory Simon , Auld Andrew , Mulenga Lloyd , Hines Jonas Z. , Fwoloshi Sombo 
Published: July 2024

Introduction
A number of seroprevalence studies in Zambia document the extent of spread of acute SARS-CoV-2 infection, yet knowledge gaps still exist on symptoms and conditions that continue or develop after acute COVID-19 (long COVID). This is an important gap given the estimated prevalence of long COVID in other African countries. We assessed factors associated with long COVID at the initial visit to a post-acute COVID-19 (PAC-19) clinic and longitudinally among a cohort of patients with ≥2 review visits.

Methods
We implemented a cross-sectional and longitudinal analysis of PAC-19 clinic patients from Aug-2020 to Jan-2023. The study outcome was long COVID; defined as the presence of new, relapsing, or persistent COVID-19 symptoms that interfere with the ability to function at home or work. Explanatory variables were demographic and clinical characteristics of patients which included sex, age group, presence of new onset medical conditions, presence of pre-existing comorbidities, vaccination status and acute COVID-19 episode details. We fitted logistic and mixed effects regression models to assess for associated factors and considered statistical significance at p<0.05.

Results
Out of a total 1,359 PAC-19 clinic patients in the cross-sectional analysis, 548 (40.3%) patients with ≥2 PAC-19 clinic visits were in the longitudinal analysis. Patients’ median age was 53 (interquartile range [IQR]: 41–63) years, 919 (67.6%) were hospitalized for acute COVID-19, and of whom 686 (74.6%) had severe acute COVID-19. Overall, 377 (27.7%) PAC-19 clinic patients had long COVID. Patients with hospital length of stay ≥15 days (adjusted odds ratio [aOR]: 5.37; 95% confidence interval [95% CI]: 2.99–10.0), severe acute COVID-19 (aOR: 3.22; 95% CI: 1.68–6.73), and comorbidities (aOR:1.50; 95% CI: 1.02–2.21) had significantly higher chance of long COVID. Longitudinally, long COVID prevalence significantly (p<0.001) declined from 75.4% at the initial PAC-19 visit to 26.0% by the final visit. The median follow-up time was 7 (IQR: 4–12) weeks.

Conclusion
Factors associated with long COVID in Zambia were consistent both cross-sectionally at the initial visit to PAC-19 clinics and longitudinally across subsequent review visits. This highlights the importance of ongoing monitoring and tailored interventions for patients with comorbidities and severe COVID-19 to mitigate the long-term impacts of COVID-19.
The feasibility of delivering cardiac brief intervention to patients following ST-elevation myocardial infarction: Protocol for a pilot randomised controlled trial
Authors: Thompson Gareth , Caughers Gemma , Bradley Judy , Donnelly Patrick , Mooney Maria , Fitzsimons Donna 
Published: July 2024

Background
Patients experience emotional distress and hold cardiac misconceptions following ST-elevation myocardial infarction. These issues informed the co-production of Cardiac Brief Intervention with patients and clinicians. The current study will establish a knowledge base for the feasibility of delivering this intervention to patients following ST-elevation myocardial infarction, with a preliminary exploration of impact on associated outcomes (ClinicalTrials.gov: NCT05848674).

Methods
A pilot randomised controlled trial incorporating a mixed-methods design will be conducted. Patients with ST-elevation myocardial infarction (number = 40) will be recruited from coronary care units at two hospital centres in Northern Ireland, with participants randomised (1:1) to the intervention or control group. Cardiac Brief Intervention constitutes a nurse-led, short (20 minutes) emotional and educational support discussion with a patient, with a leaflet that serves as a memory-aid. It will be delivered to the intervention group prior to discharge from a coronary care unit. The control group will receive standard care information. Data will be collected at baseline, post-intervention, 4 weeks from diagnosis, and 14 weeks from diagnosis. Feasibility measurements and process evaluation (quantitative and qualitative) will assess the viability of the research design and intervention delivery. Cardiac rehabilitation attendance data will be collected, and participants will complete questionnaires related to associated outcomes. Quantitative data will be reported with descriptive statistics and qualitative data will be analysed using framework analysis, with data integrated to achieve triangulation of findings.

Discussion
Educational and emotional difficulties following ST-elevation myocardial infarction may impede patient outcomes and cardiac rehabilitation participation. These issues informed the co-production of Cardiac Brief Intervention with patients and clinicians. This study will evaluate the feasibility of delivering Cardiac Brief Intervention to patients. These results will inform large-scale definitive testing of the intervention, which may lead to adoption in clinical practice to improve cardiac rehabilitation uptake and patient outcomes.
A proof-of-concept randomised controlled trial of an intervention designed to improve food hygiene behaviours among caregivers of young children living in low-income areas of Nairobi, Kenya
Authors: Watson Julie , Okumu Noah O. , Wasonga Joseph O. , Majiwa Hamilton , Kiarie Alice , Masudi Sherril P. , Ochieng Linnet , Alumasa Lorren , Mutisya Christine , Cook Elizabeth A. J. , Cumming Oliver 
Published: July 2024

Young children are particularly vulnerable to foodborne disease due to their immature immune systems. Safe food hygiene behaviours by caregivers can potentially reduce this disease burden. Here, we evaluate the potential for a locally designed intervention to improve caregivers’ food hygiene behaviour in a peri-urban, low-income area of Nairobi, Kenya. In this cluster-randomised proof-of-concept trial, 50 community health volunteers (CHVs) were randomly assigned to intervention or control arm (1:1). 101 households under the CHV’s catchment (2-3/CHV), with at least one child aged 6–24 months, participated. Caregivers in intervention households (n = 50) received the CHV-delivered food hygiene intervention. The control arm (n-51) received no intervention. Blinding was not possible due to the nature of the intervention. Our primary outcome was the proportion of caregivers observed to practice all five pre-specified food hygiene behaviours, four weeks post intervention delivery. Secondary outcomes assessed the five observed behaviours individually plus a sixth behaviour—the proportion of caregivers who report always boiling the child’s drinking water. We found no between-arm difference in the proportion of caregivers practising all five observed behaviours. However individually, five behaviours were significantly improved. Specifically, caregivers in the intervention arm had higher odds of washing their hands before feeding the child (adjusted odds ratio (aOR) = 7.40, 95%CI 1.85, 29.62) and before preparing the child’s food (aOR = 7.05, 95%CI 1.52, 32.71), washing the child’s hands before eating (aOR = 21.57, 95%CI 1.15, 405.93) and heating the child’s food (aOR = 4.03, 95%CI 1.27, 12.85) and drinking water (aOR = 12.82, 95%CI 2.54, 64.77) to boiling. There was no effect on cleaning and storage of feeding utensils. This study offers promising preliminary evidence that a CHV-led intervention targeting caregivers of young children can improve their food hygiene behaviour. Our findings warrant further research to refine the intervention and undertake larger scale trials to explore the intervention’s potential impact more comprehensively.
Trial registration: This trial was registered with Open Science Framework: osf.io/eu5kf.
Remarks on analytical solutions to compressible Navier–Stokes equations with free boundaries
Authors: Dong Jianwei , Yuen Manwai 
Published: July 2024

Abstract
In this paper, we consider the free boundary problem of the radially symmetric compressible Navier–Stokes equations with viscosity coefficients of the form μ(ρ) = ρ

θ
, λ(ρ) = (θ − 1)ρ

θ
in

R

N

${\mathbb{R}}^{N}$

. Under the continuous density boundary condition, we correct some errors in (Z. H. Guo and Z. P. Xin, “Analytical solutions to the compressible Navier–Stokes equations with density-dependent viscosity coefficients and free boundaries,” J. Differ. Equ., vol. 253, no. 1, pp. 1–19, 2012) for N = 3, θ = γ > 1 and improve the spreading rate of the free boundary, where γ is the adiabatic exponent. Moreover, we construct an analytical solution for

θ
=

2

3

$\theta =\frac{2}{3}$

, N = 3 and γ > 1, and we prove that the free boundary grows linearly in time by using some new techniques. When θ = 1, under the stress free boundary condition, we construct some analytical solutions for N = 2, γ = 2 and N = 3,

γ
=

5

3

$\gamma =\frac{5}{3}$

, respectively.
Comparisons of tracheid lengths in Pinus densiflora Siebold & Zucc.: earlywood versus latewood and province versus province
Authors: Seo Jeong-Wook , Choi En-Bi , Park Jun-Hui , Lee Yo-Seob , Lee Hyun-Mi , Kim Eun-Sook 
Published: July 2024

Abstract
The tracheid length (TL) in conifer species is a primary factor to determine quality of paper and wood products. However, TL in Pinus densiflora Siebold & Zucc., a dominant conifer species in Korea, has not been monitored systematically across the country yet. To this end, the TL of early- and latewoods of Korean red pine from 16 provinces of the Republic of Korea was measured and compared to verify the differences (1) between the monitoring years (2014–2018), (2) between early- and latewoods of the trees from the same provinces, and (3) between the early- and latewoods from different provinces. Analysis of 31,500 tracheids revealed that the variation of TL of early- and latewood from two and six out of 16 sites, respectively, were not statistically meaningful and the TL of latewood displayed a lower annual variation than that of the earlywood during the monitoring years. The TL of the latewood was longer than that of the earlywood; however, four out of 16 sites showed shorter TL for the latewood. So, it was verified that the relationship between the TL of the early- and latewood can change. Moreover, the TL was longer for the trees located in the southeast regions.
Against Melancholy Madness: The Duty of Artists
Authors: de Guillebon Baudouin 
Published: July 2024

Abstract
In this paper I explain what the duty of artists could be according to the philosopher R.G. Collingwood. My aim is not only to focus on Collingwood’s writings on the philosophy of art, but to show the parallel between the concepts used in his aesthetics and his ethics. In fact, the major role of “emotion” in both his art and moral theory gives me the occasion to develop an understanding of artists’ tasks within their communities. Moreover, it provides an occasion to define what, for Collingwood, the subject of ethics is and to explore an almost uncharted part of his work: his “Lectures on Moral Philosophy” delivered from 1921 to 1940.