bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Use of Antibiotics for the Prophylaxis of Spontaneous Bacterial Peritonitis: A Retrospective Review and Quality Improvement Study
Authors: Tagliaferri Ariana , Ansari Nida , Melki Gabriel , Cavanagh Yana 
Published: July 2024

Background: Primary and secondary prophylaxis for spontaneous bacterial peritonitis (SBP) should be reserved for high‐risk cirrhotic patients, such as those with a history of SBP, gastrointestinal (GI) hemorrhage, high Child–Pugh score, or low ascitic fluid protein (AFP) with liver and renal failure. Due to a multitude of reasons, many patients who require prophylaxis do not receive it. We present a retrospective analysis and quality improvement project. High‐risk cirrhotic patients were identified to see if antibiotic prophylaxis was initiated upon admission and the 1‐year outcomes for those individuals.Methods and Results: One hundred twenty‐six patients were included in the study. The mean age was 57.38 years. A total of 59.5% (n = 75) of patients were current or former alcohol users. A total of 54.8% (n = 69) of patients met the criteria for SBP prophylaxis; however, only 26% (n = 18) received it (p ≤ 0.073). Ciprofloxacin and cephalosporins were the most used antibiotics. Although none of the analyses for readmissions produced statistical significance, there were clinically more patients readmitted for SBP when prophylaxis was not prescribed. No patients who received prophylaxis were hospitalized within 6 months following a discharge for SBP. Only two of the 18 patients who received prophylaxis died compared to 30 of the 51 patients who did not (p ≤ 0.001). Twenty‐eight of the 32 who met the criteria but did not receive prophylaxis were deceased within 1 year following discharge (p ≤ 0.042). When stratified by basic demographics, mortality was significant in the nonprophylaxis groups for males (p ≤ 0.0001), 25–30 body mass index (BMI) group (p ≤ 0.003), and alcohol use (p ≤ 0.002).Conclusion: We intend to educate providers on the appropriate time to intervene to reduce mortality and subsequent hospitalizations for those with advanced liver disease.
Case Report: Staghorn Stone Successfully Treated With Open Nephrolithotomy
Authors: Nababan Ezra Harun Florentino , Siadary Ephram Sanders Alfian , Telussa Arley Sandra 
Published: July 2024

Objectives. Staghorn stones are large branching stones that fill part of all of the renal pelvis and renal calyces and they can be complete or partial depending on the level of occupancy of the collecting system. The case of this Staghorn Kidney Stone stone was reported at Leona hospital, Kupang, East Nusa Tenggara, Indonesia.Case. The patient is a 22 year old male with Staghorn renal stone with the size measured 14 x 11 cm. The patient came to the ER with complaints of low back pain and patient complains of difficulty urinating first. nephrolithotomy surgical procedure was performed to release the stone.Conclusion. The cause of the Renal staghorn stone should be considered prior to treatment as eliminating the cause and the underlying factor will reduce the complications and recurrence rates.
Excess Mortality and Loss of Life Expectancy After Myocardial Infarction: A Registry-Based Matched Cohort Study
Authors: Reitan Christian , Andell Pontus , Alfredsson Joakim , Erlinge David , Hofmann Robin , Lindahl Bertil , Simonsson Moa , Dickman Paul W. , Jernberg Tomas 
Published: July 2024

BACKGROUND:
The effect of myocardial infarction (MI) on life expectancy is difficult to study because the prevalence of MI hinders direct comparison with the life expectancy of the general population. We sought to assess this in relation to age, sex, and left ventricular ejection fraction (LVEF) by comparing individuals with MI with matched comparators without previous MI.

METHODS:
We included patients with a first MI between 1991 and 2022 from the nationwide SWEDEHEART registry (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies), each matched with up to 5 comparators on age, sex, and region of residence. Flexible parametric survival models were used to estimate excess mortality and mean loss of life expectancy (LOLE) depending on index year, age, sex, and LVEF, and adjusted for differences in characteristics.

RESULTS:
A total of 335 748 cases were matched to 1 625 396 comparators. A higher LOLE was observed in younger individuals, women, and those with reduced LVEF (<50%). In 2022, the unadjusted and adjusted mean LOLE spanned from 11.1 and 9.5 years in 50-year-old women with reduced LVEF to 5 and 3.7 months in 80-year-old men with preserved LVEF. Between 1992 and 2022, the adjusted mean LOLE decreased by 36% to 55%: from 4.4 to 2.0 years and from 3.3 to 1.9 years in 50-year-old women and men, respectively, and from 1.7 to 1.0 years and from 1.4 to 0.9 years in 80-year-old women and men, respectively.

CONCLUSIONS:
LOLE is higher in younger individuals, women, and those with reduced LVEF, but is attenuated when adjusting for comorbidities and risk factors. Advances in MI treatment during the past 30 years have almost halved LOLE, with no clear sign of leveling off to a plateau.
Assessing climate niche similarity between persian fallow deer (Dama mesopotamica) areas in Iran
Authors: Rahimi Ehsan , Dong Pinliang , Ahmadzadeh Faraham 
Published: July 2024

AbstractThe Persian fallow deer or Mesopotamian fallow Deer (Dama mesopotamica, Brook 1875), a species of significant ecological importance, had faced the threat of extinction in Iran. One conservation strategy involved the translocation of Persian deer to enclosed areas across Iran, where they were afforded protection from external threats and provided with essential care by human caretakers. While human caretakers diligently attend to their needs and mitigate external threats, climate variables may now become critical factors affecting population dynamics in enclosed areas. This study aims to assess the similarity in climate niches between the original area (Dez and Karkheh) of the Persian deer species and 11 newly enclosed areas. To achieve this, we employed climate data and ecological niche modeling (ENM) techniques to assess the variations in climate among 12 areas. We utilized the environmental equivalency test to determine whether the environmental spaces of area pairs exhibit significant differences and whether these spaces are interchangeable. Extrapolation analyses were also constructed in the next steps to explore climatic conditions in original fallow deer habitats that are non-analogous to those in other parts of Iran. Our results reveal significant disparities in climate conditions between the original and all translocated areas. Based on observations of population growth in specific enclosed areas where translocated deer populations have thrived, we hypothesize that the species may demonstrate a non-equilibrium distribution in Iran. Consequently, these new areas could potentially be regarded as part of the species’ potential climate niche. Extrapolation analysis showed that for a significant portion of Iran, extrapolation predictions are highly uncertain and potentially unreliable for the translocation of Persian fallow deer. However, the primary objective of translocation efforts remains the establishment of self-sustaining populations of Persian deer capable of thriving in natural areas beyond enclosed areas, thus ensuring their long-term survival and contributing to preservation efforts. Evaluating the success of newly translocated species requires additional time, with varying levels of success observed. In cases where the growth rate of the species in certain enclosed areas falls below expectations, it is prudent to consider climate variables that may contribute to population declines. Furthermore, for future translocations, we recommend selecting areas with climate similarities to regions where the species has demonstrated growth rates.
Integrated analysis of DNA methylome and transcriptome revealing epigenetic regulation of CRIR1-promoted cold tolerance
Authors: Li Zhibo , Wang Wenjuan , Yu Xiaoling , Zhao Pingjuan , Li Wenbin , Zhang Xiuchun , Peng Ming , Li Shuxia , Ruan Mengbin 
Published: July 2024

Abstract
Background
DNA methylation contributes to the epigenetic regulation of nuclear gene expression, and is associated with plant growth, development, and stress responses. Compelling evidence has emerged that long non-coding RNA (lncRNA) regulates DNA methylation. Previous genetic and physiological evidence indicates that lncRNA-CRIR1 plays a positive role in the responses of cassava plants to cold stress. However, it is unclear whether global DNA methylation changes with CRIR1-promoted cold tolerance.

Results
In this study, a comprehensive comparative analysis of DNA methylation and transcriptome profiles was performed to reveal the gene expression and epigenetic dynamics after CRIR1 overexpression. Compared with the wild-type plants, CRIR1-overexpressing plants present gained DNA methylation in over 37,000 genomic regions and lost DNA methylation in about 16,000 genomic regions, indicating a global decrease in DNA methylation after CRIR1 overexpression. Declining DNA methylation is not correlated with decreased/increased expression of the DNA methylase/demethylase genes, but is associated with increased transcripts of a few transcription factors, chlorophyll metabolism and photosynthesis-related genes, which could contribute to the CRIR1-promoted cold tolerance.

Conclusions
In summary, a first set of transcriptome and epigenome data was integrated in this study to reveal the gene expression and epigenetic dynamics after CRIR1 overexpression, with the identification of several TFs, chlorophyll metabolism and photosynthesis-related genes that may be involved in CRIR1-promoted cold tolerance. Therefore, our study has provided valuable data for the systematic study of molecular insights for plant cold stress response.
Analytical and clinical performance evaluation of a new NT-proBNP assay
Authors: Feng Pingfeng , Qin Junlong , Chai Zhixin , Zhang Yajie , Zhao Minghai , Liu Liya , Zhang Lijun , Chen Yaqiong , Xiong Yufeng 
Published: July 2024

Abstract
Background
The study evaluated the performance of the Mindray N-terminal pro-B-type natriuretic peptide (NT-proBNP) in a healthy population in China, focusing on creating a reference range for future clinical applications adjusted according to different demographics.

Methods
The study measured NT-proBNP in 2277 healthy individuals. We analyzed age and sex-stratified data, performed precision, accuracy, linearitcvy, and detection limit studies, and evaluated method comparison and consistency between Roche and Mindray assays on 724 serum samples. We used Excel 2010, Medcalc, and GraphPad Prism 9.

Results
In males, the 97.5th centile NT-proBNP concentration at age < 45, 45 to 54, 55 to 64, 65 to 74 and ≧ 75 were 89.4 ng/L, 126 ng/L, 206 ng/L, 386 ng/L and 522 ng/L, respectively. In females, the concentration of NT-proBNP at the same age was 132 ng/L, 229 ng/L, 262 ng/L, 297 ng/L and 807 ng/L, respectively. The repeatability precision coefficient of variation (CV%) for NT-proBNP was between 0.86 and 1.65 in analytical performance. In contrast, the reproducibility precision (CV%) for NT-proBNP was between 1.52 and 3.22, respectively. The study found a bias of accuracy of 3.73% in low-value samples (concentration: 148.69) and 7.31% in high-value samples (concentration: 1939.08). The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of 125 ng/L were 96.6%, 92.3%, 84.2%, and 98.5%, respectively. In contrast, those of 300 ng/L were 94.0%, 98.2%, 95.7% and 97.5%, respectively.

Conclusions
The Mindray NT-proBNP assay showed increased levels in both males and females with age, with higher levels in women. It performs well and aligns with manufacturer specifications. We recommend adjusting cutoff values based on demographic factors.
A latent bleeding complication in ipsilateral common femoral puncture involving delayed diagnosis: a case report
Authors: Nomura Tetsuya , Yoshida Shiori , Kitamura Michitaka , Ono Kenshi , Shoji Keisuke , Kato Yukinori , Wada Naotoshi , Keira Natsuya , Tatsumi Tetsuya 
Published: July 2024

Abstract
Background
The trans femoral ipsilateral approach is often adopted for endovascular treatment (EVT) for better steerability of guidewires or better device deliverability. However, contrary to the trans femoral contralateral approach, ipsilateral antegrade puncture sometimes causes peculiar bleeding complications.

Case presentation
A 76-year-old female underwent EVT for chronic occlusion of the left superficial femoral artery (SFA) via the ipsilateral antegrade approach. After guidewire passage, we inflated the drug-coated balloons, but angiography showed blood flow stasis at the mid segment of the SFA. We also ensured prolonged balloon inflation, which resulted in favorable blood flow. While trying to ensure hemostasis, the blood pressure remained decreased, but neither bleeding nor superficial hematoma were observed at the puncture site. After hemostasis was achieved, we removed the surgical drape and noticed a swelling in the mid-portion of the thigh, distant from the puncture point. We then approached the left common femoral artery (CFA) contralaterally. Angiography showed continuous bleeding from a little bit distally to the sheath insertion point that was spreading through an intramuscular space. We stopped the bleeding with balloon tamponade inside the CFA. Angiography after hemostasis demonstrated blood flow stasis at the mid-segment of the SFA, similarly as that seen before. We confirmed compression of the SFA by a large hematoma using both intra- and extra- vascular ultrasound. Therefore, we deployed a self-expandable stent at the compressed SFA position. Finally, we achieved favorable blood flow on angiography.

Conclusion
We encountered a case that latent bleeding unrecognized in the surgical field persisted while prolonged inflation of DCB was conducted at just proximal SFA. We could have avoided bailout stenting by noticing the bleeding incident in a timely manner. Prediction and prevention are essential for all kinds of procedural complications in EVT.
Evaluating diabetes care in primary healthcare centers in Abuja, Nigeria: a cross-sectional formative assessment
Authors: Orji Ikechukwu A. , Baldridge Abigail S. , Ikechukwu-Orji Mercy U. , Banigbe Bolanle , Eze Nelson C. , Chopra Aashima , Omitiran Kasarachi , Iyer Guhan , Odoh Deborah , Alex-Okoh Morenike , Reng Rifkatu , Hirschhorn Lisa R. , Huffman Mark D. , Ojji Dike B. 
Published: July 2024

Abstract
Introduction
Noncommunicable diseases (NCDs) are associated with high and rising burden of morbidity and mortality in sub-Saharan Africa, including Nigeria. Diabetes mellitus (DM) is among the leading causes of NCD-related deaths worldwide and is a foremost public health problem in Nigeria. As part of National policy, Nigeria has committed to implement the World Health Organization (WHO) Package of Essential Non-communicable Disease interventions for primary care. Implementing the intervention requires the availability of essential elements, including guidelines, trained staff, health management information systems (HMIS), equipment, and medications, in primary healthcare centers (PHCs). This study assessed the availability of the DM component of the WHO package, and the readiness of the health workers in these PHCs to implement a DM screening, evaluation, and management program to inform future adoption and implementation.

Methods
This cross-sectional formative assessment adapted the WHO Service Availability and Readiness Assessment (SARA) tool to survey 30 PHCs selected by multistage sampling for readiness to deliver DM diagnosis and care in Abuja, Nigeria, between August and October 2021. The SARA tool was adapted to focus on DM services and the availability and readiness indicator scores were calculated based on the proportion of PHCs with available DM care services, minimum staff requirement, diagnostic tests, equipment, medications, and national guidelines/protocols for DM care within the defined SARA domain.

Results
All 30 PHCs reported the availability of at least two full-time staff (median [interquartile range] = 5 [4–9]), which were mostly community health extension workers (median [interquartile range]) = 3 [1–4]. At least one staff member was recently trained in DM care in 11 PHCs (36%). The study also reported high availability of paper-based HMIS (100%), and DM screening services using a glucometer (87%), but low availability of DM job aids (27%), treatment (23%), and national guidelines/protocols (0%).

Conclusion
This formative assessment of PHCs’ readiness to implement a DM screening, evaluation, and management program in Abuja demonstrated readiness to integrate DM care into PHCs regarding equipment, paper-based HMIS, and nonphysician health workers' availability. However, strategies are needed to promote DM health workforce training, provide DM management guidelines, and supply essential DM medications.
Change in suicidal ideation, depression, and anxiety following collaborative care in the community
Authors: Khazanov Gabriela Kattan , Wolk Courtney Benjamin , Lorenc Emily , Candon Molly , Pieri Matteo F. , Oslin David W. , Press Matthew J. , Anderson Eleanor , Famiglio Emilie , Jager-Hyman Shari 
Published: July 2024

Abstract
Background
The Collaborative Care Model (CoCM) increases access to mental health treatment and improves outcomes among patients with mild to moderate psychopathology; however, it is unclear how effective CoCM is for patients with elevated suicide risk.

Methods
We examined data from the Penn Integrated Care program, a CoCM program including an intake and referral management center plus traditional CoCM services implemented in primary care clinics within a large, diverse academic medical system. In this community setting, we examined: (1) characteristics of patients with and without suicidal ideation who initiated CoCM, (2) changes in suicidal ideation (Patient Health Questionnaire-9 [PHQ-9] item 9), depression (PHQ-9 total scores), and anxiety (Generalized Anxiety Disorder Scale-7 scores) from the first to last CoCM visit overall and across demographic subgroups, and (3) the relationship between amount of CoCM services provided and degree of symptom reduction.

Results
From 2018 to 2022, 3,487 patients were referred to CoCM, initiated treatment for at least 15 days, and had completed symptom measures at the first and last visit. Patients were 74% female, 45% Black/African American, and 45% White. The percentage of patients reporting suicidal ideation declined 11%-7% from the first to last visit. Suicidal ideation severity typically improved, and very rarely worsened, during CoCM. Depression and anxiety declined significantly among patients with and without suicidal ideation and across demographic subgroups; however, the magnitude of these declines differed across race, ethnicity, and age. Patients with suicidal ideation at the start of CoCM had higher depression scores than patients without suicidal ideation at the start and end of treatment. Longer CoCM episodes were associated with greater reductions in depression severity.

Conclusions
Suicidal ideation, depression, and anxiety declined following CoCM among individuals with suicidal ideation in a community setting. Findings are consistent with emerging evidence from clinical trials suggesting CoCM’s potential for increasing access to mental healthcare and improving outcomes among patients at risk for suicide.
Association and temporal sequence of pneumonia and gastrointestinal bleeding after acute ischemic stroke
Authors: Zhang Runhua , Hou Huiqing , Zhao Xingquan , Liu Liping , Wang Yilong , Liu Gaigen , Wang Yongjun , Ji Ruijun 
Published: July 2024

Abstract
Background
Stroke-associated pneumonia (SAP) and gastrointestinal bleeding (GIB) are common medical complications after stroke. The previous study suggested a strong association between SAP and GIB after stroke. However, little is known about the time sequence of SAP and GIB. In the present study, we aimed to verify the association and clarify the temporal sequence of SAP and GIB after ischemic stroke.

Methods
Patients with ischemic stroke from in-hospital Medical Complication after Acute Stroke study were analyzed. Data on occurrences of SAP and GIB during hospitalization and the intervals from stroke onset to diagnosis of SAP and GIB were collected. Multiple logistic regression was used to evaluate the association between SAP and GIB. Kruskal-Wallis test was used to compare the time intervals from stroke onset to diagnosis of SAP and GIB.

Results
A total of 1129 patients with ischemic stroke were included. The median length of hospitalization was 14 days. Overall, 86 patients (7.6%; 95% CI, 6.1-9.2%) developed SAP and 47 patients (4.3%; 95% CI, 3.0-5.3%) developed GIB during hospitalization. After adjusting potential confounders, SAP was significantly associated with the development of GIB after ischemic stroke (OR = 5.13; 95% CI, 2.02-13.00; P < 0.001). The median time from stroke onset to diagnosis of SAP was shorter than that of GIB after ischemic stroke (4 days vs. 5 days; P = 0.039).

Conclusions
SAP was associated with GIB after ischemic stroke, and the onset time of SAP was earlier than that of GIB. It is imperative to take precautions to prevent GIB in stroke patients with SAP.
Dental complications as a potential indicator of Redondovirus infection: a cross-sectional study
Authors: Mohebbi Alireza , Kiani Seyed Jalal , Khanaliha Khadijeh , Donyavi Tahereh , Emtiazi Nikoo , Sharifian Kimia , Mohebbi Maryam , Gholami Amytis , Behnezhad Farzane , Abbasi-Kolli Mohammad , Dehghani-Dehej Farzaneh , Bokharaei-Salim Farah 
Published: July 2024

Abstract
Background
Redondoviridae is a newly discovered virus family linked to oral and respiratory conditions in people, while there is still debate about whether it is also coinfected with other respiratory viruses. This study aimed to determine the frequency of Redondovirus (ReDoV) in nasopharyngeal samples and to investigate any possible links to SARS-CoV-2 infections.

Methods
A polymerase chain reaction (PCR) test was conducted on 731 nasopharyngeal samples from individuals referred to medical centers in Tehran, Iran, for SARS-CoV-2 testing to investigate the prevalence of ReDoV. An oral interview was performed to complete information on dental issues and the individuals’ demographics, symptoms, and vaccination history.

Results
The prevalence of ReDoV was 25.99%, and 15.26% had a coinfection with SARS-CoV-2. No notable correlation was found regarding ReDoVs and SARS-CoV-2 infections (p > 0.05). Women had a higher ReDoV positivity rate of 18.47% compared to men at 7.52% (p = 0.12), and there was no significant correlation between age groups and ReDoV presence. Nonetheless, a significant association was noted between ReDoVs and dental/gum issues (p < 0.0001, OR: 13.0326). A phylogenetic analysis showed that ReDoVs originated from various human-related clusters.

Conclusions
These results highlight the potential for detecting ReDoVs in nasopharyngeal samples of people with gum or dental issues. Additionally, conducting more ReDoV epidemiological research and proposing oral health as a possible marker for ReDoV infections is important.