bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventricular fibrillation during football training as a consequence of kratom and caffeine use in an adolescent: case report
Authors: Dodulík Jozef , Plášek Jiří , Handlos Petr , Gřegořová Andrea , Václavík Jan 
Published: July 2024

Abstract

Background
There is an increase in the sale of legal drugs in our country. One of these substances is kratom. Kratom (Mitragyna speciosa) is a partial agonist of the opioid kappa, mu, and delta receptors. It acts as a stimulant at low concentrations, making users feel more energetic and euphoric. It has sedative and antinociceptive effects at higher doses.

Case summary
An 18-year-old man collapsed during football training and required cardiopulmonary resuscitation; the initial rhythm was ventricular fibrillation managed by defibrillation. Laboratory parameters were unremarkable. Blood samples sent for toxicological evaluation were positive for kratom and caffeine. Echocardiographic examination, coronary computed tomography angiography, and cardiac magnetic resonance imaging did not prove the cause. Genetic testing did not find a pathogenic gene variant associated with familial ventricular fibrillation, but a variant of unknown significance was found in MYOM1. Given this situation, we implanted an implantable cardioverter-defibrillator (ICD) from the secondary prevention of sudden cardiac death (SCD) according to the guidelines of the European Society of Cardiology (ESC). No recurrence of ventricular arrhythmia has been reported by ambulatory ICD memory checks on our patient.

Discussion
In some country, kratom is freely available and sold as a plant, not a drug. Only incident cases of ventricular fibrillation after kratom use are described in the literature. There is insufficient scientific evidence linking kratom to ventricular fibrillation. This is an absolutely crucial case report of this type, which has not yet been published in similar circumstances in the world. Therefore, the development of ventricular fibrillation was assumed to be due to a combination of kratom, caffeine, and exercise. The safety profile and effects of kratom should be the subject of future research. We would like to stress the importance of reporting further case series for more scientific evidence and thus increasing the pressure for stricter availability and regulation of kratom in some countries, especially where it is over-the-counter.
First application of the distal radial approach for severe mechanical surgical aortic valve paravalvular leak transcatheter closure with a double vascular plug: a case report
Authors: Sasi Viktor , Fontos Géza , Kormányos Árpád , Vértesaljai Márton , Ruzsa Zoltán 
Published: July 2024

Abstract

Background
Severe aortic paravalvular leaks (PVLs) after surgical mechanical aortic valve replacement (AVR) represent a high risk for congestive heart failure, haemolysis, and infective endocarditis. This is the first reported case of distal radial artery (DRA) access for severe mechanical aortic PVL closure with a sequential double vascular plug guided by computed tomography angiography (CTA), transoesophageal echocardiography (TOE), and 3D TOE in an acute setting.

Case summary
A 51-year-old male presented with significant mixed aortic valve disease. Aortic valve replacement was performed (Slimline Bicarbon A-25 mm) according to guidelines. Four and 16 days later, a re-exploration was carried out due to pericardial effusion. Four months after discharge from rehabilitation, the patient was readmitted due to worsening dyspnoea on exertion and then at rest. Transthoracic echocardiography, TOE, and consequently, CTA, revealed severe PVL, following which the procedure of transcatheter PVL closure was chosen, with a preference for DRA access. After a CTA scan analysis and angiographic, TOE, and 3D TOE visualization of the leak, a 14/5 mm and a 10/5 mm vascular plug (AVPIII) were deployed to achieve good results. A 9-month clinical, echocardiographic, and CTA follow-up revealed good long-term results.

Discussion
For transcatheter PVL closure, CTA is helpful for not only vascular access planning, but also a visualization of the magnitude of the leak, location, and device planning. This case report demonstrates that the distal radial approach is feasible in patients with severe mechanical aortic valve PVL retrograde transcatheter closure. DRA access could possibly represent less bleeding and vascular access site complications when compared with femoral access and has some potential advantages over regular radial access.
A case report of reversible left ventricular dysfunction due to azathioprine hypersensitivity syndrome
Authors: Lüscher Daniel , Maeder Micha T , Scheler Eva 
Published: July 2024

Abstract

Background
Hypersensitivity reaction is a rare side effect during immunosuppressive treatment with azathioprine (AZA). Some cases of cardiac involvement have already been reported but causality is notoriously difficult to prove.

Case summary
We present the case of a 68-year-old man with two episodes of reversible left ventricular (LV) dysfunction. One month after treatment initiation with AZA, he developed non-specific symptoms, including mild chest pain. In the context of elevated cardiac biomarkers and markers of inflammation, echocardiography showed depressed systolic LV function. Biventricular dysfunction was shown on cardiac magnetic resonance imaging (CMR), but neither myocardial oedema nor late gadolinium enhancement was documented. There was full recovery of LV function after AZA discontinuation. Very similar clinical course and echocardiography findings were observed early after restarting AZA treatment. After definitive cessation of AZA, systolic LV function recovered again and remained stable throughout long-term follow-up.

Discussion
Hypersensitivity reaction with cardiac involvement due to AZA is rare. The exact mechanisms underlying AZA-related cardiac dysfunction are still not completely understood, and causality is often difficult to prove. However, because of re-exposure to the drug, which, considered retrospectively, was inappropriate, the effect was clearly apparent in our patient. Knowledge of this potentially life-threatening side effect of AZA treatment is important. AZA must be discontinued promptly if there is any evidence of hypersensitivity reaction.
Relative Income and Mental Health in Couples
Authors: Getik Demid 
Published: July 2024

Abstract
The share of couples where the wife outearns the husband is increasing globally. In this paper, I examine how this dynamic affects mental health. Using data on the 2001 marital cohort in Sweden, I show that while mental health is positively associated with own and spousal income, it is negatively linked to the wife’s relative income. In the most conservative specification, the wife starting to earn more increases the likelihood of a mental health diagnosis by 8%–11%. This represents a significant indirect cost of changes in family dynamics.
Diagnostic reliability of monitoring for premature atrial and ventricular complexes
Authors: Måneheim Alexandra , Economou Lundeberg Johan , Persson Anders P , Edegran Albin , Grotek-Cuprjak Agnieszka , Juhlin Tord , Benezet-Mazuecos Juan , Ellenbogen Kenneth A , Engström Gunnar , Healey Jeff S , Johnson Linda S 
Published: July 2024

Abstract

Aims
Short-term ambulatory electrocardiogram (ECG) monitoring is often used to assess premature atrial complex (PAC) and premature ventricular complex (PVC) frequency, but the diagnostic reliability is unknown. The objective of this study was to study the day-to-day variability of PAC and PVC frequency.

Methods and results
We used 14-day full-disclosure mobile cardiac telemetry recordings without atrial fibrillation in 8245 US patients aged 17–103 years to calculate the diagnostic reliability of shorter ambulatory ECG recordings compared with 14-day averages. Over 14 days, 1853 patients had ≥500 PACs/day, 410 patients had ≥5000 PACs/day, and 197 patients had ≥10 000 PACs/day; 1640 patients had ≥500 PVCs/day, 354 patients had ≥5000 PVCs/day, and 175 patients had ≥10 000 PVCs/day. After 3 days, the estimated daily PAC frequency differed by ≥50% from the 14-day mean in 25% of patients; for PVCs, the corresponding duration was 7 days. Ten days of monitoring were needed to estimate PAC and PVC frequency within ±20% of the overall 14-day frequency in 80% of patients. For daily PAC and PVC frequencies ≥10 000, single-day estimation had a specificity of 99.3% [95% confidence interval (CI) 99.1–99.5] at a sensitivity of 76.6 (95% CI 70.1–80.4%) for PACs and a 99.6% (95% CI 99.4–99.7%) specificity at 79.4 (95% CI 72.7–85.2) sensitivity for PVCs. After 7 days, the sensitivity increased to 88.8% (95% CI 83.6–92.9) for PACs and 86.9% (95% CI 80.9–91.5%) for PVCs.

Conclusion
While there is substantial daily variability across most PAC and PVC levels, findings of ≥10 000 PACs or PVCs are highly specific and do not need to be confirmed with longer recordings.
Still waters run deep: a unique case of mummification under extreme conditions
Authors: Flouri Despoina E , Kougios Efstratios , Fasoulakis Efthimios , Spanakis Konstantinos , Kranioti Elena F , Papadomanolakis Antonios 
Published: July 2024

Abstract In rural Crete, Greece, a mummified body was discovered inside a screw-top plastic barrel next to a dry riverbed. Local authorities conducted a field investigation along with a forensic pathologist, and the body was transferred inside the barrel to the Forensic Medicine Unit of the University of Crete for further investigation. Forensic examination included radiographs taken using a portable X-ray machine in situ followed by extraction of the remains, a full-body postmortem computed tomography scan, autopsy, DNA extraction, tissue and biofluid sampling, and histological and toxicological analyses. Two butane camping gases were recovered from inside the barrel. The remains were determined to belong to a middle-aged adult male. The postmortem interval was estimated to be over 4 months. DNA comparison revealed that the body belonged to a 58-year-old man who was reported missing 28 months prior to discovery. Examinations showed no evidence of skeletal or other trauma, and death was attributed to asphyxia due to oxygen deprivation. Careful examination of the barrel, which bore several peculiar modifications, in conjunction with contextual information pertaining to the deceased’s personal life, led to successful case resolution.Key points
Observations from the seafloor: ultra-low-frequency ambient ocean-bottom nodal seismology at the Amendment field
Authors: Girard A J , Shragge J , Danilouchkine M , Udengaard C , Gerritsen S 
Published: July 2024

SUMMARY
Large-scale ocean-bottom node (OBN) arrays of 1000s of multicomponent instruments deployed over 1000s of square kilometres have been used successfully for active-source seismic exploration activities including full waveform inversion (FWI) at exploration frequencies above about 2.0 Hz. The analysis of concurrently recorded lower-frequency ambient wavefield data, though, is only just beginning. A key long-term objective of such ambient wavefield analyses is to exploit the sensitivity of sub-2.0 Hz energy to build long-wavelength initial elastic models, thus facilitating FWI applications. However, doing so requires a more detailed understanding of ambient wavefield information recorded on the seafloor, the types, frequency structure and effective source distribution of recorded surface-wave modes, the near-seafloor elastic model structure, and the sensitivity of recorded wave modes to subsurface model structure. To this end, we present a wavefield analysis of low- and ultra-low-frequency ambient data (defined as &lt;1.0 and &lt;0.1 Hz, respectively) acquired on 2712 OBN stations in the Amendment Phase 1 survey covering 2750 km2 of the Gulf of Mexico. After applying ambient data conditioning prior to cross-correlation and seismic cross-coherence interferometry workflows, we demonstrate that the resulting virtual shot gather (VSG) volumes contain evidence for surface-wave and guided P-wave mode propagation between the 0.01 and 1.0 Hz that remains coherent to distances of at least 80 km. Evidence for surface-wave scattering from near-surface salt-body structure between 0.35 and 0.85 Hz is also present in a wide spatial distribution of VSG data. Finally, the interferometric VSG volumes clearly show waveform repetition at 20 s intervals in sub-0.3 Hz surface-wave arrivals, a periodicity consistent with the mean active-source shot interval. This suggests that the dominant contribution of surface-wave energy acquired in this VSG frequency band is likely predominantly related to air-gun excitation rather than by naturally occurring energy sources. Overall, these observations may have important consequences for the early stages of initial model building for elastic FWI analysis.
Slip rates and locking depths of the southern Sumatran Fault Zone revealed by new campaign GPS observations
Authors: Lubis Ashar Muda , Salman Rino , Hermawan Iwan , Bradley Kyle , Feng Lujia , Qiu Qiang , Sahputra Rio , Natawidjaja Danny H , Sieh Kerry , Hill Emma M 
Published: July 2024

SUMMARY
The Sumatran Fault Zone (SFZ) of the Indonesian island of Sumatra, which is broken up into 19 fault segments, accommodates much of the trench-parallel component of the oblique convergence between the Indo-Australian and Sunda plates. To understand the potential hazard of SFZ earthquakes to the local population, we investigate slip rates and locking depths of three SFZ segments in southern Sumatra using previously unpublished data from our Sumatran Fault Monitoring (SuMo) campaign Global Positioning System (GPS) network. We model the GPS data using a 2-D interseismic dislocation model optimized using a Bayesian approach. For the Musi segment of the SFZ, we find that slip rates ranging from 10 to 22 mm yr−1 and locking depths from 1 to 20 km fit the data similarly well, suggesting a lack of resolution for the SuMo network in this segment. For the Manna and Kumering segments where the resolution is better, the estimated slip rates are 18 [12–22, 95 per cent confidence intervals] mm yr−1 and 12 [9–15] mm yr−1, respectively, while the estimated locking depths are 29 [15–47] km and 5 [3–16] km, respectively. The deep locking depth estimated for the Manna segment can be explained by the large station gap in this segment. Considering the uncertainty, all the estimated slip rates from our study remains aligned with the SFZ's average slip rate of ∼15 mm yr−1, which was previously derived using updated geological slip rates and geodetic block modelling of the entire SFZ. Our results support the idea that the forearc sliver west of the SFZ behaves as a rigid microplate.
Anomalously fertile subcontinental lithospheric mantle beneath the intracontinental Canning Basin, Western Australia
Authors: Moro P S , Aitken A R A , Kohanpour F , Jessell M W 
Published: July 2024

SUMMARY
Many intracontinental basins form as broad depressions through prolonged, slow subsidence of the continental lithosphere. Such long-lived basins can record lithospheric processes over hundreds of millions of years, serving as important archives of lithospheric evolution. Since continental amalgamation in the Mesoproterozoic, the lithosphere beneath the intracontinental Canning Basin has been subject to several tectonic events, with extensive crustal reworking evidenced through different upper crust data sets. However, knowledge of the structure of the subcontinental lithospheric mantle is lacking. As a consequence, understanding the coupled evolution between surface and deep lithospheric processes, crucial to resolving basin formation, development and survival, remains problematic. Here, we combine geochemical, geophysical and petrophysical data within a thermodynamic modelling framework to determine the thermochemical properties, rheology, density and seismic structure of the lithospheric and sublithospheric mantle beneath the Canning Basin. The results indicate a thick, rigid lithosphere with a maximum thickness of 185 km and strength of ca. 1 × 1013 Pa m, and an anomalously Fe-enriched subcontinental lithospheric mantle with a Mg# of 88.6. This mantle structure is not consistent with pre-collisional fragments or a Precambrian collisional setting and may reflect magmatic refertilization during high-volume mafic magmatic events. Potential candidate events are the ∼1070 Ma Warakurna, ∼825 Ma Gairdner and ∼510 Ma Kalkarindji Large Igneous Provinces. The youngest of these is temporally and spatially correlated with and therefore interpreted to have influenced the Canning Basin formation. We propose that refertilization caused a negatively buoyant subcontinental lithospheric mantle and prolonged subsidence and preservation of the basin, while the strong lithosphere ensured lithospheric stability and longevity.
The impact of ambient noise sources in subsurface models estimated from noise correlation waveforms
Authors: Valero Cano Eduardo , Fichtner Andreas , Peter Daniel , Mai P Martin 
Published: July 2024

SUMMARY
Cross-correlations of seismic ambient noise are frequently used to image Earth structure. Usually, tomographic studies assume that noise sources are uniformly distributed and interpret noise correlations as empirical Green’s functions. However, previous research suggests that this assumption can introduce errors in the estimated models, especially when noise correlation waveforms are inverted. In this paper, we investigate changes in subsurface models inferred from noise correlation waveforms depending on whether the noise source distribution is considered to be uniform. To this end, we set up numerical experiments that mimic a tomographic study in Southern California exploiting ambient noise generated in the Pacific Ocean. Our results show that if the distribution of noise sources is deemed uniform instead of being numerically represented in the wave simulations, the misfit of the estimated models increases. In our experiments, the model misfit increase ranges between 5 and 21 per cent, depending on the heterogeneity of the noise source distribution. This indicates that assuming uniform noise sources introduces source-dependent model errors. Since the location of noise sources may change over time, these errors are also time-dependent. In order to mitigate these errors, it is necessary to account for the noise source distribution. The spatial extent to which noise sources must be considered depends on the propagation distance of the ambient noise wavefield. If only sources near the study area are considered, model errors may arise.
Taking the Pulse of Resilience in Conserving Seagrass Meadows
Authors: Graham Olivia J , Harvell Drew , Christiaen Bart , Gaeckle Jeff , Aoki Lillian R , Ratliff Baylen , Vinton Audrey , Rappazzo Brendan H , Whitman Tina 
Published: July 2024

Synopsis
Foundational habitats such as seagrasses and coral reefs are at severe risk globally from climate warming. Infectious disease associated with warming events is both a cause of decline and an indicator of stress in both habitats. Since new approaches are needed to detect refugia and design climate-smart networks of marine protected areas, we test the hypothesis that the health of eelgrass (Zostera marina) in temperate ecosystems can serve as a proxy indicative of higher resilience and help pinpoint refugia. Eelgrass meadows worldwide are at risk from environmental stressors, including climate warming and disease. Disease outbreaks of Labyrinthula zosterae are associated with recent, widespread declines in eelgrass meadows throughout the San Juan Islands, Washington, USA. Machine language learning, drone surveys, and molecular diagnostics reveal climate impacts on seagrass wasting disease prevalence (proportion of infected individuals) and severity (proportion of infected leaf area) from San Diego, California, to Alaska. Given that warmer temperatures favor many pathogens such as L. zosterae, we hypothesize that absent or low disease severity in meadows could indicate eelgrass resilience to climate and pathogenic stressors. Regional surveys showed the San Juan Islands as a hotspot for both high disease prevalence and severity, and surveys throughout the Northeast Pacific indicated higher prevalence and severity in intertidal, rather than subtidal, meadows. Further, among sites with eelgrass declines, losses were more pronounced at sites with shallower eelgrass meadows. We suggest that deeper meadows with the lowest disease severity will be refuges from future warming and pathogenic stressors in the Northeast Pacific. Disease monitoring may be a useful conservation approach for marine foundation species, as low or absent disease severity can pinpoint resilient refugia that should be prioritized for future conservation efforts. Even in declining or at-risk habitats, disease surveys can help identify meadows that may contain especially resilient individuals for future restoration efforts. Our approach of using disease as a pulse point for eelgrass resilience to multiple stressors could be applied to other habitats such as coral reefs to inform conservation and management decisions.
Recent Progress in the Physical Principles of Dynamic Ground Self-Righting
Authors: Li Chen 
Published: July 2024

Synopsis
Animals and robots must self-right on the ground after overturning. Biology research has described various strategies and motor patterns in many species. Robotics research has devised many strategies. However, we do not well understand the physical principles of how the need to generate mechanical energy to overcome the potential energy barrier governs behavioral strategies and 3D body rotations given the morphology. Here, I review progress on this which I led studying cockroaches self-righting on level, flat, solid, low-friction ground, by integrating biology experiments, robotic modeling, and physics modeling. Animal experiments using three species (Madagascar hissing, American, and discoid cockroaches) found that ground self-righting is strenuous and often requires multiple attempts to succeed. Two species (American and discoid cockroaches) often self-right dynamically, using kinetic energy to overcome the barrier. All three species use and often stochastically transition across diverse strategies. In these strategies, propelling motions are often accompanied by perturbing motions. All three species often display complex yet stereotyped body rotation. They all roll more in successful attempts than in failed ones, which lowers the barrier, as revealed by a simplistic 3D potential energy landscape of a rigid body self-righting. Experiments of an initial robot self-righting via rotation about a fixed axis revealed that the longer and faster appendages push, the more mechanical energy can be gained to overcome the barrier. However, the cockroaches rarely achieve this. To further understand the physical principles of strenuous ground self-righting, we focused on the discoid cockroach’s leg-assisted winged self-righting. In this strategy, wings propel against the ground to pitch the body up but are unable to overcome the highest pitch barrier. Meanwhile, legs flail in the air to perturb the body sideways to self-right via rolling. Experiments using a refined robot and an evolving 3D potential energy landscape revealed that, although wing propelling cannot generate sufficient kinetic energy to overcome the highest pitch barrier, it reduces the barrier to allow small kinetic energy from the perturbing legs to probabilistically overcome the barrier to self-right via rolling. Thus, only by combining propelling and perturbing can self-righting be achieved when it is so strenuous; this physical constraint leads to the stereotyped body rotation. Finally, multi-body dynamics simulation and template modeling revealed that the animal’s substantial randomness in wing and leg motions helps it, by chance, to find good coordination, which accumulates more mechanical energy to overcome the barrier, thus increasing the likelihood of self-righting.