bluuebunny/crossref_metadata_2025_split huggingface dataset:
Vingt-cinq ans de périurbanisation logistique
Authors: Guerrero David , Proulhac Laurent 
Published: April 2015

Cette recherche analyse la dynamique spatiale des activités logistiques depuis le milieu des années 1980 jusqu’à présent, en s’appuyant sur des données sur les permis de construire dans 350 aires urbaines françaises. L’analyse de l’ensemble des aires urbaines d’un pays permet d’apporter un éclairage nouveau à la question de la périurbanisation, en s’interrogeant sur les différentes formes qu’elle a prises au cours du temps. Le travail démontre que, loin de se limiter au seul sommet de la hiérarchie urbaine, la périurbanisation des activités logistiques se produit également dans des aires urbaines de plus petite taille. Ce mouvement généralisé des activités logistiques vers le périurbain ne se fait pas de manière homogène mais en différentes vagues. Il s’est effectué dans un premier temps de manière dispersée pour ensuite se concentrer sur un petit nombre de pôles logistiques. Ces résultats confortent l’hypothèse, avancée par des travaux récents, selon laquelle les activités logistiques, poussées par les économies d’agglomération, auraient tendance à s’implanter à proximité d’autres activités logistiques.
La philosophie dans la prédication du judaïsme espagnol du xiii e au xvi e siècle
Authors: Rothschild Jean-Pierre 
Published: April 2015

À la différence du sermon chrétien, le sermon juif n’est pas essentiel à la vie religieuse et le prédicateur n’a guère de statut. Il est pourtant une réalité sociale et littéraire de premier plan en Espagne. Que la philosophie ait place dans ce genre qui s’adresse à tous s’éclaire par trois choses : les textes que la liturgie amène à prendre pour occasions de la prédication ; la « reconfiguration rationaliste du judaïsme » par Maïmonide ; la résistance au prosélytisme. D’où des sujets spéculatifs (création, libre arbitre, justice absolue ou dans l’intérêt public, service par crainte ou par amour, etc.), des références aux auteurs philosophiques, juifs ou non, un lexique et un type d’argumentation. Les conversions nombreuses lors des persécutions de 1391 firent apparaître la nécessité d’une prédication adaptée aux besoins du peuple. Les perspectives ouvertes par l’ Éthique à Nicomaque traduite en hébreu vers 1400 et l’exemple de la prédication chrétienne donnèrent lieu au milieu du xv e s. au programme de Joseph Ibn Shem Tov regardant le rôle du prédicateur, qui exprimait l’emprise de la philosophie sur les penseurs juifs les plus soucieux de sauvegarder la foi. La spécificité du judaïsme se désignait comme un savoir, selon deux modèles : celui, non avoué, de la scolastique chrétienne, avec une théologie au-dessus de la philosophie, et celui d’un niveau inaccessible aux autres hommes. Mais ce savoir spécifique ne se laisse guère cerner. Après 1492, des réfugiés d’Espagne dans l’Empire Ottoman tendirent à l’identifier au corpus des homélies des rabbins anciens : Jacob Ibn Ḥabib en procura le recueil, Salomon ha-Lévi en fit la théorie. L’avantage définitif pris par la kabbale de Safed à la fin du xvi e s. a-t-il pour cause l’échec de cette recherche, ou bien en va-t-il autrement ?
Luther et l’objet de la prédication
Authors: Büttgen Philippe 
Published: April 2015

Luther, comme beaucoup d’autres, a eu une pratique de la prédication et un discours sur la prédication. En héritant du programme barthien d’une « théologie de la Parole de Dieu » (Wort-Gottes-Theologie) , la Lutherforschung a semblé creuser l’écart entre cette pratique et ce discours. Aujourd’hui, les attendus dogmatiques de la Wort-Gottes-Theologie (définition de la théologie comme kérygme) comme ses revendications pratiques (la prédication au centre de l’action ecclésiale) déterminent et barrent en partie l’accès à plusieurs opérations de pensée significatives des recherches de Luther dans les décennies 1510-1530. Certaines d’entre elles se heurtent délibérément aux exigences universitaires que la théologie, jusqu’à Luther, avait accepté de se laisser imposer. On en examinera trois : transformations de l’exégèse de Rm 10, 17, fides ex auditu ; mise au point d’un concept du prêchable comme indice du vrai en théologie ; définition d’un scopus generalis de toute prédication. Ces trois opérations furent des tentatives ; elles ne furent pas toutes couronnées de succès. Elles inaugurent cependant le programme d’une recherche à mener sur l’objet de la prédication dans les premières théologies de la Réforme.
La philosophie et les philosophes dans les sermons de Calvin
Authors: Millet Olivier 
Published: April 2015

De nature homilétique, la prédication de Calvin suit le principe de la lectio continua , proche du commentaire des lectiones . Le réformateur mentionne souvent les philosophes, de manière positive pour les savoirs qu’ils représentent, mais aussi pour les critiquer. La philosophie et les philosophes sont des réalités ambivalentes, comme dans l’ Institution de la religion chrestienne , et désignent les savoirs humains sur le monde et sur l’homme en tant qu’on peut ou qu’on ose envisager ces réalités comme indépendantes de Dieu. Les plus grands éloges de la philosophie donnent lieu aux condamnations les plus vives. Calvin utilise aussi la désignation de philosophes pour critiquer des adversaires contemporains : d’une part la théologie scolastique et tridentine, d’autre part les « moyenneurs » érasmiens. Le réformateur oppose les deux « styles », celui de la philosophie et celui de la révélation scripturaire, à la fois comme deux méthodes discursives, deux styles au sens littéraire, et deux stratégies : seules les Écritures saintes sont capables de conduire efficacement à la vraie sagesse (chrétienne).
Recycled IL-7 Can Be Delivered to Neighboring T Cells
Authors: Bazdar Douglas A. , Kalinowska Magdalena , Panigrahi Soumya , Sieg Scott F. 
Published: April 2015

Abstract
IL-7 is a key homeostatic cytokine that provides signals for T cell survival and proliferation in vivo. In this article, we provide evidence that IL-7 utilization is enhanced by a novel mechanism of cytokine “recycling” during which T cells treated with rIL-7 are rapidly induced to express p-STAT5 and are subsequently able to recycle biologically active cytokine for release to neighboring cells in soluble form. Our observations indicate that the ability of cells to recycle IL-7 is dependent on IL-7R α-chain (CD127) and endocytosis, consistent with a model whereby IL-7 is internalized via receptor interactions before recycling. These observations provide evidence of a novel mechanism that enables cells to optimally use IL-7.
MF59 Mediates Its B Cell Adjuvanticity by Promoting T Follicular Helper Cells and Thus Germinal Center Responses in Adult and Early Life
Authors: Mastelic Gavillet Beatris , Eberhardt Christiane S. , Auderset Floriane , Castellino Flora , Seubert Anja , Tregoning John S. , Lambert Paul-Henri , de Gregorio Ennio , Del Giudice Giuseppe , Siegrist Claire-Anne 
Published: April 2015

Abstract
The early life influenza disease burden calls for more effective vaccines to protect this vulnerable population. Influenza vaccines including the MF59 oil-in-water adjuvant induce higher, broader, and more persistent Ab responses in adults and particularly in young, through yet undefined mechanisms. In this study, we show that MF59 enhances adult murine IgG responses to influenza hemagglutinin (HA) by promoting a potent T follicular helper cells (TFH) response, which directly controls the magnitude of the germinal center (GC) B cell response. Remarkably, this enhancement of TFH and GC B cells is already fully functional in 3-wk-old infant mice, which were fully protected by HA/MF59 but not HA/PBS immunization against intranasal challenge with the homologous H1N1 (A/California/7/2009) strain. In 1-wk-old neonatal mice, MF59 recruits and activates APCs, efficiently induces CD4+ effector T cells and primes for enhanced infant responses but induces few fully functional TFH cells, which are mostly follicular regulatory T cells, and poor GC and anti-HA responses. The B cell adjuvanticity of MF59 appears to be mediated by the potent induction of TFH cells which directly controls GC responses both in adult and early life, calling for studies assessing its capacity to enhance the efficacy of influenza immunization in young infants.
High-Density Lipoprotein Attenuates Th1 and Th17 Autoimmune Responses by Modulating Dendritic Cell Maturation and Function
Authors: Tiniakou Ioanna , Drakos Elias , Sinatkas Vaios , Van Eck Miranda , Zannis Vassilis I. , Boumpas Dimitrios , Verginis Panayotis , Kardassis Dimitris 
Published: April 2015

Abstract
Aberrant levels and function of the potent anti-inflammatory high-density lipoprotein (HDL) and accelerated atherosclerosis have been reported in patients with autoimmune inflammatory diseases. Whether HDL affects the development of an autoimmune response remains elusive. In this study, we used apolipoprotein A-I–deficient (apoA-I−/−) mice, characterized by diminished circulating HDL levels, to delineate the role of HDL in autoimmunity. ApoA-I−/− mice exhibited increased severity of Ag-induced arthritis compared with wild-type mice, and this was associated with elevated Th1 and Th17 cell reactivity in the draining lymph nodes. Furthermore, reconstituted HDL (rHDL) attenuated IFN-γ and IL-17 secretion by Ag-specific T cells upon stimulation of draining lymph nodes in vitro. The suppressive effects of rHDL were mediated through modulation of dendritic cell (DC) function. Specifically, rHDL-treated DCs demonstrated an immature phenotype characterized by downregulated costimulatory molecules, the release of low amounts of proinflammatory cytokines, and failure to promote T cell proliferation in vitro. The mechanism of action involved the inhibition of NF-κB nuclear translocation and the decrease of Myd88 mRNA levels by rHDL. Finally, modulation of DC function by rHDL was critically dependent on the presence of scavenger receptor class B type I and ATP Binding Cassette Transporter A1, but not the ATP Binding Cassette Transporter G1. These findings reveal a novel role of HDL in the regulation of adaptive inflammatory responses through suppression of DC function that could be exploited therapeutically in autoimmune inflammatory diseases.
Young, Proliferative Thymic Epithelial Cells Engraft and Function in Aging Thymuses
Authors: Kim Mi-Jeong , Miller Christine M. , Shadrach Jennifer L. , Wagers Amy J. , Serwold Thomas 
Published: April 2015

Abstract
The thymus reaches its maximum size early in life and then begins to shrink, producing fewer T cells with increasing age. This thymic decline is thought to contribute to age-related T cell lymphopenias and hinder T cell recovery after bone marrow transplantation. Although several cellular and molecular processes have been implicated in age-related thymic involution, their relative contributions are not known. Using heterochronic parabiosis, we observe that young circulating factors are not sufficient to drive regeneration of the aged thymus. In contrast, we find that resupplying young, engraftable thymic epithelial cells (TECs) to a middle-aged or defective thymus leads to thymic growth and increased T cell production. Intrathymic transplantation and in vitro colony-forming assays reveal that the engraftment and proliferative capacities of TECs diminish early in life, whereas the receptivity of the thymus to TEC engraftment remains relatively constant with age. These results support a model in which thymic growth and subsequent involution are driven by cell-intrinsic changes in the proliferative capacity of TECs, and further show that young TECs can engraft and directly drive the growth of involuted thymuses.
In Vitro and In Vivo Analysis of the Gram-Negative Bacteria–Derived Riboflavin Precursor Derivatives Activating Mouse MAIT Cells
Authors: Soudais Claire , Samassa Fatoumata , Sarkis Manal , Le Bourhis Lionel , Bessoles Stéphanie , Blanot Didier , Hervé Mireille , Schmidt Frédéric , Mengin-Lecreulx Dominique , Lantz Olivier 
Published: April 2015

Abstract
Mucosal-associated invariant T (MAIT) cells recognize microbial compounds presented by the MHC-related 1 (MR1) protein. Although riboflavin precursor derivatives from Gram-positive bacteria have been characterized, some level of ligand heterogeneity has been suggested through the analysis of the MAIT cell TCR repertoire in humans and differential reactivity of human MAIT cell clones according to the bacteria. In this study, using Gram-negative bacteria mutated for the riboflavin biosynthetic pathway, we show a strict correlation between the ability to synthesize the 5-amino-ribityl-uracil riboflavin precursor and to activate polyclonal and quasi-monoclonal mouse MAIT cells. To our knowledge, we show for the first time that the semipurified bacterial fraction and the synthetic ligand activate murine MAIT cells in vitro and in vivo. We describe new MR1 ligands that do not activate MAIT cells but compete with bacterial and synthetic compounds activating MAIT cells, providing the capacity to modulate MAIT cell activation. Through competition experiments, we show that the most active synthetic MAIT cell ligand displays the same functional avidity for MR1 as does the microbial compound. Altogether, these results show that most, if not all, MAIT cell ligands found in Escherichia coli are related to the riboflavin biosynthetic pathway and display very limited heterogeneity.
IL-33 Reverses an Obesity-Induced Deficit in Visceral Adipose Tissue ST2+ T Regulatory Cells and Ameliorates Adipose Tissue Inflammation and Insulin Resistance
Authors: Han Jonathan M. , Wu Dan , Denroche Heather C. , Yao Yu , Verchere C. Bruce , Levings Megan K. 
Published: April 2015

Abstract
Obesity is associated with insulin resistance and inflammation thought to be caused by a visceral adipose tissue (VAT)–localized reduction in immunoregulatory cells and increase in proinflammatory immune cells. We previously found that VAT regulatory T cells (Tregs) normally express high levels of IL-10 and that expression of this cytokine in VAT Tregs is specifically reduced in mice fed a high-fat diet. In this study, we further investigated the phenotype of VAT Tregs and found that the majority of IL-10–expressing Tregs in the VAT of lean mice also expressed the ST2 chain of the IL-33R. In addition to high expression of IL-10, ST2+ Tregs in lean VAT expressed higher proportions of Th2-associated proteins, including GATA3 and CCR4, and Neuropillin-1 compared with ST2− Tregs. The proportion of ST2+ Tregs in VAT was severely diminished in obese mice that had been fed a high-fat/sucrose diet, and this effect could be completely reversed by treatment with IL-33. IL-33 treatment also reversed VAT inflammation in obese mice and resulted in a reduction of hyperinsulinemia and insulin resistance. These data suggest that IL-33 contributes to the maintenance of the normal pool of ST2+ Tregs in the VAT, and that therapeutic administration of IL-33 results in multiple anti-obesity effects, including the reversal of VAT inflammation and alleviation of insulin resistance.
Clinton’s Grand Strategy
Authors: Boys James D. 
Published: April 2015

President Clinton’s time in office coincided with historic global events following the end of the Cold War. The collapse of Communism called for a new US Grand Strategy to address the emerging geopolitical era that brought upheavals in Somalia and the Balkans, economic challenges in Mexico and Europe and the emergence of new entities such as the EU, NAFTA and the WTO. Clinton's handling of these events was crucial to the development of world politics at the dawn of the twenty-first century. Only by understanding Clinton’s efforts to address the challenges of the post-Cold War era can we understand the strategies of his immediate successors, George W. Bush and Barack Obama, both of whom inherited and continued Clinton-era policies and practices.
James D. Boys sheds new light on the evolution and execution of US Grand Strategy from 1993 to 2001. He explores the manner in which policy was devised and examines the actors responsible for its development, including Bill Clinton, Anthony Lake, Samuel Berger, Warren Christopher, Madeline Albright and Richard Holbrook. He examines the core components of the strategy (National Security, Prosperity Promotion and Democracy Promotion) and how they were implemented, revealing a hitherto unexplored continuity from campaign trail to the White House.
Covering the entire duration of Clinton’s presidential odyssey, from his 1991 Announcement Speech to his final day in office, the book draws extensively on newly declassified primary materials and interviews by the author with key members of the Clinton administration to reveal for the first time the development and implementation of US Grand Strategy from deep within the West Wing of the Clinton White House.
Food and Identity in England, 1540–1640
Authors: Lloyd Paul S. 
Published: April 2015

Food and Identity in England, 1540-1640 considers early modern food consumption in an important new way, connecting English consumption practices between the reigns of Henry VIII and Charles I with ideas of ‘self’ and ‘otherness’ in wider contexts of society and the class system.
Examining the diets of various social groups, ranging from manual labourers to the aristocracy, special foods and their preparation, as well as festive events and gift foods, this all-encompassing study reveals the extent to which individuals and communities identified themselves and others by what and how they ate between the Reformation of the church and the English Civil Wars. This text provides remarkable insights for anyone interested in knowing more about the society and culture of early modern England.
The Black Pacific
Authors: Shilliam Robbie 
Published: April 2015

Why have the struggles of the African Diaspora so resonated with South Pacific people? How have Maori, Pasifika and Pakeha activists incorporated the ideologies of the African diaspora into their struggle against colonial rule and racism, and their pursuit of social justice?
This book challenges predominant understandings of the historical linkages that make up the (post-)colonial world. The author goes beyond both the domination of the Atlantic viewpoint, and the correctives now being offered by South Pacific and Indian Ocean studies, to look at how the Atlantic ecumene is refracted in and has influenced the Pacific ecumene. The book is empirically rich, using extensive interviews, participation and archival work and focusing on the politics of Black Power and the Rastafari faith. It is also theoretically sophisticated, offering an innovative hermeneutical critique of post-colonial and subaltern studies.
The Black Pacific is essential reading for students and scholars of Politics, International Relations, History and Anthropology interested in anti-colonial struggles, anti-racism and the quests for equality, justice, freedom and self-determination.
Christian Metal
Authors: Moberg Marcus 
Published: April 2015

Christian metal has always defined itself in contrast to its non-Christian, secular counterpart, yet it stands out from nearly all other forms of contemporary Christian music through its unreserved use of metal’s main musical, visual, and aesthetic traits. Christian metal is a rare example of a direct combination between evangelical Christianity and an aggressive and highly controversial form of popular music and its culture.
Christian Metal: History, Ideology, Scene is the first full exploration of the phenomenon of Christian metal music, its history, main characteristics, development, diversification, and key ideological traits from its formative years in the early 1980s to the present day. Marcus Moberg situates it in a wider international evangelical cultural environment, accounts for its diffusion on a transnational scale, and explores what religious meanings and functions Christian metal holds for its own musicians and followers. Engaging with wider debates on religion, media and popular culture, Christian Metal: History, Ideology and Scene is a much-needed resource in the study of religion and popular music.
Cinema of Simulation
Authors: Laist Randy 
Published: April 2015

Hyperreality is an Alice-in-Wonderland dimension where copies have no originals, simulation is more real than reality, and living dreams undermine the barriers between imagination and objective experience. The most prominent philosopher of the hyperreal, Jean Baudrillard, formulated his concept of hyperreality throughout the 1980s, but it was not until the 1990s that the end of the Cold War, along with the proliferation of new reality-bending technologies, made hyperreality seem to come true. In the “lost decade” between the fall of the Berlin Wall and 9/11, the nature of reality itself became a source of uncertainty, a psychic condition that has been recognizably recorded by that seismograph of American consciousness, Hollywood cinema.
The auteur cinema of the 1970s aimed for gritty realism, and the most prominent feature of Reagan-era cinema was its fantastic unrealism. Clinton-era cinema, however, is characterized by a prevailing mood of hyperrealism, communicated in various ways by such benchmark films as JFK, Pulp Fiction, and The Matrix. The hyperreal cinema of the 1990s conceives of the movie screen as neither a window on a preexisting social reality (realism), nor as a wormhole into a fantastic dream-dimension (escapism), but as an arena in which images and reality exchange masks, blend into one another, and challenge the philosophical premises which differentiate them from one another. Cinema of Simulation: Hyperreal Hollywood in the Long 1990s provides a guided tour through the anxieties and fantasies, reciprocally social and cinematic, which characterize the surreal territory of the hyperreal.
Influence of Response–Effect Feedback on Learning and Performance of a Complex Key- Pressing Task: Morin and Grant (1955) Revisited
Authors: Chen Jing , Proctor Robert W. 
Published: April 2015

Abstract
Response effects, also called action effects, are events produced as a consequence of a response. morin and Grant (1955) conducted an 8- choice task in which, when one of the response keys was pressed, a feedback light (i.e., response effect) was lit in a row below the stimulus lights. across participants, stimulus–response and response–effect mappings varied in compatibility, ranging from perfectly corresponding, to random, to perfectly mirror- reversed mapping. after several practice sessions, the feedback lights were removed in a transfer session, and response times increased greatly, particularly for the mappings without much structure, indicating reliance on the feedback during practice. We revisited this paradigm by means of 2 experiments that examined the influence on acquisition and transfer performance of task instruction, reliability of the visual feedback, and task difficulty. lower task difficulty and unreliable visual feedback resulted in superior performance in the transfer session, indicating better learning of the stimulus–response mapping and less reliance on the feedback during learning. task instructions that emphasized learning of the mapping or indicated that there would be a later test without the feedback lights did not influence participants’ performance in the transfer session. these findings are discussed in relation to several of Healy and colleagues’ principles of skill acquisition and transfer and in the context of contemporary research on response–effect associations.