bluuebunny/crossref_metadata_2025_split huggingface dataset:
Saúde reprodutiva feminina e agroquímicos: revisão sistemática de modelos toxicológicos in vitro
Authors: Bento Iamara Carvalho Sabatino , Silva Giovanna Rafael Fernandes da , Castro Raiane Cristina Fratini de , Siviero Eloísa dos Santos , Sagawa Viviane Sayuri Mitzutani , Agostinis Andressa Jaqueline , Moraes Adriano Junqueira de , Emanuelli Isabele Picada 
Published: August 2024

O uso indiscriminado e negligente de antimicrobianos, como os antibióticos em práticas veterinárias, pode favorecer a seleção de genes resistentes na cadeia alimentar humana, causando a resistência bacteriana. Dessa forma, este artigo apresenta uma revisão sistemática acerca das evidências disponíveis na literatura sobre estudos de triagem de antimicrobianos em leite animal e derivados, visando orientar futuras medidas de saúde pública e melhoria dos processos de produção. No presente estudo, coletamos dados de artigos publicados entre os anos de 2005 e 2021 sobre a presença de resíduos de antibióticos em leite animal e seus derivados. Dentre os artigos selecionados (n=7), a grande maioria são de Países Europeus (n=4). Das espécies de animais estudadas nos artigos temos vaca e cabra, sendo leite cru (n=7), leite UHT (n=2), leite pasteurizado (n=1), colostro (n=1) e queijo (n=1) as amostras de produtos de leite animal e derivados analisadas. O método analítico mais empregado nas triagens foi o LC/MS (n=4), e do total de amostras de produtos analisadas, 22,75% (n=491) testaram positivas para algum dos tipos de antibióticos. Foram identificados 18 tipos de antibióticos nos artigos, sendo as tetraciclinas e os betalactâmicos os mais presentes, configurando respectivamente, 17,24% e 13,29% dos produtos. O número de artigos encontrados indicou claramente haver uma escassez de estudos sobre triagem de antimicrobianos em leite animal e derivados. Os resultados do presente estudo destacam o risco desses agentes antimicrobianos em alimentos de origem animal para a saúde pública.
Efeito imunomodulador do extrato bruto de pouteria caimito na resposta imunológica humoral
Authors: Almeida Renata de , Silva Lusinalva Leonardo da , Silva Fabiana Teixeira e , Vericimo Mauricio Afonso 
Published: August 2024

Pouteria Caimito (Ruiz e Pav.) Radlk é uma espécie pertencente à família da Sapotaceae, conhecida popularmente como Abiu e, que inclui aproximadamente 50 gêneros e 1000 espécies, onde no Brasil ocorrem 14 gêneros e em torno de 200 espécies, com destaque na Floresta Amazônica. Algumas dessas espécies vêm apresentando importantes resultados como: inibidor de fungos e larvas, atividade antioxidante e atividade anti-câncer. O presente trabalho tem por objetivo geral avaliar o efeito imunomodulador do extrato de Pouteria Caimito (EBbor) na resposta imunológica humoral. Nos ensaios in vivo, grupos de camundongos receberam, pela via intraperitoneal (IP), 1000 ug/Kg de EBbor para contagem do número total das células do sangue periférico (SP) e análise dos linfócitos B e T do baço e medula óssea (MO). Na avaliação imunomoduladora os camundongos foram imunizados com 5ug de OVA associada à 2mg de hidróxido de alumínio (OVA+HA) ou OVA+HA associada ao EBbor e os níveis de anticorpos anti-OVA determinados pela reação de ELISA. A imunidade celular anti-OVA foi avaliada através da reação de hipersensibilidade retardada no pavilhão auricular. Os resultados obtidos revelaram no 40 dia, diminuição de leucócitos circulantes no SP com retorno ao nível basal no 120 dia. No baço, verificou-se uma redução de células recuperadas, assim como número de linfócitos B, no 80 dia. Por outro lado, as células T apresentaram elevações transitórias tanto na contagem relativa como na absoluta. Já na MO foram observados um aumento transitório de células recuperadas e caracterizado por uma redução do número de células B e nenhuma alteração de células T. Os camundongos imunizados com OVA, associada ao EBbor, apresentaram uma expressiva diminuição dos níveis de anticorpos IgG anti-OVA. A reação de hipersensibilidade tardia anti-OVA e a rejeição aguda de transplante de pele não foram afetadas. Conclui-se que a administração IP do EBbor em camundongos reduz células B no baço e na medula óssea sem alteração das células T. Além disso, ao ser associada na imunização reduz a produção de anticorpos. Esses achados demonstram a possibilidade de um promissor produto natural de origem vegetal com ação seletiva sobre as células B.
Indicadores empíricos para estruturação de um instrumento de consulta de enfermagem à mulher no climatério
Authors: Dutra Michelinne Oliveira Machado , Baptista Rosilene Santos , Araújo Michelly Guedes de Oliveira , Cerqueira Ana Carolina Dantas Rocha , Sousa Francisco Stélio de , França Inácia Sátiro Xavier de 
Published: August 2024

Durante o climatério acontecem modificações fisiológicas na mulher, evidenciadas por mudanças hormonais, funcionais, morfológicas, e outras nos sistemas hormoniodependentes, como ossos e cardiovascular. Essas mudanças repercutem na saúde da mulher, sendo capaz de interferir na autoestima, qualidade de vida e longevidade. Desse modo, objetivou-se identificar e validar os indicadores empíricos das mulheres no climatério para estruturação de um instrumento de consulta de enfermagem à luz da Teoria das Necessidades Humanas básicas. Trata-se de uma pesquisa metodológica desenvolvida em duas etapas: a primeira, mediante identificação dos indicadores empíricos relacionados à mulher no climatério; e a segunda, por meio da validação destes indicadores. Foram identificados 153 indicadores empíricos relativos às necessidades humanas básicas, dos quais 112 representam as necessidades psicobiológicas, 40 às necessidades psicossociais e um referente à necessidade psicoespiritual. Concernente à validação dos Indicadores Empíricos, os resultados demonstraram que a concordância das respostas alcançou o mínimo de 0,85. A partir da identificação e validação dos indicadores empíricos alterados da mulher no climatério à luz da teoria das Necessidades Humanas Básicas, será possível desenvolver e instrumento válido para Consulta de Enfermagem à mulher no climatério no âmbito da atenção primária em saúde.
Theoretical application in healthcare practice for vulnerable patients admitted to the Julio Trigo López Clinical and Surgical Hospital
Authors: Hernández López Yamilet de la Caridad , Ortega Dugrot Yanet , San Martín Cuesta Yeneisy , Zulueta Alejo Ana Rosa , Méndez Espinosa Idorkis 
Published: August 2024

Introduction: nursing professionals carry with them a very important position that relates health with society, which implies that they must continually investigate and search for scientific bases to help improve the quality of the care provided in the processes carried out. Objective: to describe the theoretical application in the practice of care for vulnerable patients admitted to the Julio Trigo López Clinical and Surgical Hospital. Method: a systematic review and analysis of the bibliographic and documentary content was carried out, in order to develop a reflexive analysis of the content of the documents published at national and international level related to the topic addressed, interviews with managers and care staff of the Julio Trigo López Clinical and Surgical Hospital, opinions and experiences narrated, together with the authors' criteria, based on their actions, were incorporated. Results: it is essential that nurses implement the application of the proposed nursing theories in this type of patients who need more than a physical figure to bathe them, feed them, provide them with medical treatment, the nurse-patient interpersonal relationships are the basis of the nursing discipline, to ensure holistic care, based on a moral commitment, through values of respect for the dignity of life. Conclusions: the application of nursing theories in the care practice of vulnerable patients validates the professional performance, enriching the nursing thought that is continuously evolving.
Identification of Numeracy Skills of Elementary School Students in Working on National Assesment Problems
Authors: Ristanto Setya , Rahaju Endah Budi , Mariana Neni 
Published: August 2024

Objective: The study aims to determine the numeracy skills of students. In addition, this study aims to determine misconceptions in solving numeracy questions based on national assessments. Method: This research uses a descriptive qualitative method—data obtained from test results, documentation, and interviews with subjects. Results: The results of this study are that the numeracy skills of Genilangit 2 Elementary School have almost the same score as the 2024 Education Report Card score. Overall, the numeracy skills of Genilangit 2 Elementary school students are in the good category. However, it can still be optimized again for a better numeracy score. Students still experience misconceptions (conceptual, procedural, and technical errors) when solving numeracy problems. Novelty: The novelty of this research is that this research focuses on analyzing the numeracy skills of students who have taken computer-based national assessments done manually on paper. Later, more detailed information will be obtained about the numeracy skills of students and the misconceptions of numeracy students. This research explores detailed information because the questions given are in the form of descriptions so that students' steps in working on problems are known.
Meningkatkan Hasil Belajar IPS Sub Tema Lingkungan dan Manfaatnya melalui Model Pembelajaran Tipe Group Investigation Siswa Kelas V-B SD Negeri 24 Buton Kabupaten Buton
Authors: Matje Irman 
Published: August 2024

Tujuan penelitian yang ingin dicapai adalah Mendeskripsikan peningkatan hasil belajar IPS Sub Tema Lingkungan dan Manfaatnya melalui penerapan model pembelajaran tipe Group Investigation siswa kelas V-B SD Negeri 24 Buton. Prosedur penelitian ini meliputi: perencanaan, pelaksanaan tindakan, observasi dan evaluasi, dan refleksi. Teknik pengumpulan data dalam penelitian ini menggunakan lembar observasi aktivitas guru dan siswa, dan evaluasi tes siklus. Teknik analisis data dalam penelitian ini menggunakan analisis deskriptif yaitu menghitung persentase aktivitas guru, aktivitas siswa dan ketuntasan hasil belajar siswa selama proses pembelajaran. Indikator keberhasilan dalam penelitian ini terdiri dua yaitu dari segi proses dan hasil. Dilihat dari segi proses, tindakan dikatakan berhasil apabila minimal 85% proses pelaksanaan pembelajaran terlaksana dengan baik. Dilihat dari segi hasil, tindakan dikatakan berhasil apabila minimal 80% dari jumlah siswa mencapai nilai ≥ 70. Penerapan model pembelajaran kooperatif tipe Group Investigation dapat meningkatkan hasil belajar IPS siswa kelas V-B SD Negeri 24 Buton. Hal ini tampak pada hasil tes siklus I yang menunjukkan bahwa 8 orang dari 19 siswa telah mencapai ketuntasan belajar sebesar 42,1%, sementara hasil tes siklus II menunjukkan bahwa 17 siswa dari 19 siswa telah mencapai ketuntasan belajar sebesar 89,48%, dan peningkatan persentase tersebut sebesar 47,4%. Demikian pula nilai rata-rata meningkat dari 61,67 menjadi 78,42. Disimpulkan bahwa penerapan model pembelajaran kooperatif tipe Group Investigation pada sub tema Lingkungan dan Manfaatnya dapat meningkatkan hasil belajar siswa pada mata pelajaran IPS di kelas V-B SD Negeri 24 Buton Kabupaten Buton.
Pembaharuan Kurikulum MTI Batang Kabung: Analisis Bahan Ajar
Authors: Malfi Febri , Sudirman  , Nurdin Syafruddin , Kosim Muhammad 
Published: August 2024

Tujuan penelitian ini adalah untuk mengetahui pembaharuan kurikulum yang dilakukan oleh MTI Batang Kabung pada aspek bahan ajar, baik bahan ajar bidang umum maupun pondok, kemudian untuk mengetahui dampak pembaharuan bahan ajar tersebut terhadap lulusan. Penelitian ini merupakan penelitian lapangan (field research) yang bersifat kualitatif dengan menggunakan metode deskriptif. Sumber data primer dalam penelitian ini adalah pimpinan, kepala Madrasah dan majelis guru di MTI Batang Kabung. Kemudian sumber data sekunder adalah buku-buku yang relevan dengan penelitian. Teknik pengumpulan data yang digunakan yakni wawancara, observasi dan studi dukumentasi. Data yang telah terkumpul kemudian diolah dengan cara reduksi data, penyajian data dan penarikan kesimpulan. Seiring dengan perkembangan zaman, MTI Batang Kabung mulai melakukan pembaharuan kurikulum, terutama pada aspek bahan ajar, baik mata pelajaran umum, maupun mata pelajaran pondok. Kendati melakukan pembaharuan pada aspek bahan ajar, MTI Batang Kabung tetap berpegang teguh pada sistem nilai Ahlusunnah Waljama’ah dan bermazhab Syafi’i. Pembaharuan dimulai pada tahun 2004/2005. Pada saat itu MTI Batang Kabung menerapkan kurikulum berbasis kompetensi (KBK) dan pada tahun 2006/2007 MTI Batang Kabung menerapkan Kurikulum Tingkat Satuan Pendidikan (KTSP). Dengan berubahnya kurikulum pendidikan sekarang maka PPMTI Batang Kabung juga mengikut dengan program pemerintah yaitu kurikulum 2013, selanjutnya mempersiapkan diri untuk menyesuaikan dengan kurikulum merdeka yang baru digagas pemerintah. MTI Batang Kabung bisa dikatakan sebagai pondok pesantren yang menyelenggarakan sistem pondok pesantren dan sekaligus sistem sekolah/madrasah. Saat ini pada bidang pelajaran pondok, kitab yang diajarkan lebih banyak daripada dahulu, yang mana dahulu hanya diajarkan beberapa kitab saja, yaitu per bidang ilmu hanya satu kitab yang diajarkan. Pada ada saat ini per bidang keilmuan, kitab yang diajarkan sudah berbagai macam dan berkelanjutan. Pembaharuan yang dilakukan oleh MTI Batang Kabung pada kurikulum, khususnya pada bahan pengajaran cukup memberikan beberapa dampak positif bagi lulusannya, diantaranya santri lebih mahir dalam pembelajaran umum, santri mampu bersaing di perguruan tinggi umum dan santri bisa melamar pekerjaan di bidang apa saja apabila telah tamat dari MTI Batang Kabung.
Gambaran Kejadian Menstruasi di SMP Negeri 1 Malunda
Authors: Immawanti Immawanti 
Published: August 2024

Masa remaja merupakan masa peralihan yang dialami oleh remaja laki-laki dan perempuan. Masa peralihan remaja mengalami perubahan biologi, psikologis serta kematangan organ reproduksi. Perubahan yang terjadi salah satunya menstruasi. Tujuan penelitian ini untuk mengetahui gambaran kejadian menstruasi pada siswi SMP Negeri 1 Malunda. Jenis penelitian ini adalah deskriptif analitik. Jumlah sampel dalam penelitian ini adalah 56 orang. Pengambilan sampel berdasarkan random sampling dengan teknik purposive sampling. Hasil penelitian didapatkan mayoritas responden berusia 15 tahun (41.0%), skala nyeri yang dirasakan umumnya skala ringan (67.9%), dampak dari nyeri menstruasi sebagaian besat responden tetap beraktivitas dan masuk sekolah (75%) dan terapi yang digunakan dalam mengatasi nyeri dengan istirahat dan tidak melakukan apa – apa (35.8%). Pentingnya penyediaan Unit Kesehatan Sekolah (UKS) sehingga dapat memberikan ruang kepada siswa untuk mendapatkan terapi saat menstruasi
Sosialisasi Budidaya Ternak Puyuh dan Demplot Pencampuran Daun Mengkudu Dalam Pakan Untuk Meningkatkan Produksi Ternak Puyuh
Authors: Horhoruw Wiesje Martha , Kewilaa Arnold Ismael 
Published: August 2024

Ternak puyuh belum banyak dipelihara di Kecamatan Leitimur Selatan. Puyuh mempunyai keunikan, yaitu pertumbuhannya cepat, lebih cepat dewasa kelaminl, dan produksi telurnya relatif tinggi. Salah satu faktor untuk meningkatkan produksi telur puyuh adalah dengan perbaikan pakan. Mengkudu merupakan salah satu tanaman obat yang kandungan gizinya dapat meningkatkan produksi ternak puyuh. Tujuan dari kegiatan ini adalah pembuatan dan pemberian daun mengkudu dalam pakan untuk meningkatkan produksi ternak puyuh. Penambahan tepung daun mengkudu dan sari buah mengkudu dalam pakan memberikan pengaruh yang signifikan terhadap umur dewasa kelamin, warna kuning telur, produksi telur, berat telur, dan kandungan kolesterol kuning telur. Daun mengkudu segar dapat diberikan kepada ternak puyuh dengan cara dicacah terlebih dahulu menjadi ukuran lebih kecil sehingga mudah dikonsumsi. Metode yang dipakai guna menyelesaikan persoalan yang dihadapi peternak untuk mengelola ternak adalah: pengamatan langsung di lokasi guna mengetahui sistem pemeliharaan, sedangkan sosialisasi dilakukan secara tatap muka, diskusi atau tanya jawab, dan demplot pencampuran daun mengkudu pada pakan ternak puyuh. Capaian dari kegiatan yang telah dilakukan adalah: Peningkatan pengetahuan, keterampilan dan motivasi tentang beternak puyuh yang baik dan benar, Peningkatan pengetahuan, keterampilan dan motivasi dalam pemeliharaan ternak puyuh akan meningkatkan sumber pangan bergizi asal ternak puyuh dan juga dapat meningkatkan pendapatan keluarga
A Rare Case of Tentorial Sinus Thrombosis in a Patient with Sickle Cell Disease
Authors: Nadkarni Vineet , Dengri Chetna , Nouh Amre , Koriesh Ahmed 
Published: August 2024

Background: The reported incidence of venous thromboembolism in sickle cell disease patients is approximately 12% before the age of 40, accompanied by an additional 5-10% incidence of cerebral venous sinus thrombosis. Tentorial sinuses are venous structures in the posterior cranial fossa, draining the occipital and temporal lobes and the superior part of the cerebellum. Here, we describe a rare case of lateral tentorial sinus thrombosis in a patient with sickle cell disease.

Methods: Case report and review of the available literature

Results: A 26-year-old woman with sickle cell disease presented with a 2-day history of headache, nausea, and vomiting. Neurological exam was normal. CT brain revealed hyperdensity in the right occipital region and subtle area of hypodensity in the right medial occipital lobe. MRI/MRV brain showed right lateral tentorial sinus and occipitobasal vein thrombosis in addition to right medial occipital lobe venous infarct. The patient was started on therapeutic heparin initially, then transitioned to apixaban. Hemoglobin electrophoresis revealed a HbS fraction of 80.6% and HbF 16.6%. The patient received an exchange transfusion and was discharged home in stable condition.

Conclusions: In patients with symptoms concerning for cerebral venous thrombosis, attention is usually directed to the traditional dural venous sinuses and cortical veins, while other venous structures can be overlooked. Although, in this particular case, it was clear on imaging, tentorial sinus thrombosis can easily be missed if not associated with brain edema or venous infarct.
Analisis Urgensi Pendidikan Akhlak Berkarakter Dalam Membangun Keluarga Bahagia
Authors: Annisa Fitri Dewianti  , Farhah Desrianty Gimri  , Elsa Marfina Nandiani  , Bambang Ardiansyah  , Wismanto Wismanto  
Published: August 2024

This article aims to explain how important moral education is starting from within the family where parents play a major role in educating children and are responsible for the development of their souls and beliefs. The method of writing in this article is carried out by the library research method. From the results of this study it can be concluded that happiness and well-being are not always related to one's success in reaching the peak or sufficient material, but can be obtained through the appreciation and practice of religious teachings. Therefore, humans are required to prepare themselves and family experts with religious education as the basic capital in carrying out life in this world and provisions for the hereafter. One of the main things is religious education which must be learned from an early age, because the teachings of Islam must be the foundation or guidance in the subsequent development of the child's soul.
Pengaruh Metode Al-Barqy Terhadap Kemampuan Membaca Al-Qur’an di MDA Nurul Ihsan Mudiak Lolo Barat Kecamatan Sungai Pagu Kabupaten Solok Selatan
Authors: Nurul Irvani  , Junaidi Junaidi  , Albaihaqi Anas  , Nurhasnah Nurhasnah  
Published: August 2024

The purpose of this study was to determine how the Al-Barqy method affects the ability to read the Al-Qur’an at MDA Nurul Ihsan Mudiak Lolo Barat Sungai Pagu District South Solok Regency. This research uses pre-experimental methodology and is quantitative in nature. The number of grade I-IV MDA students who became the population of this study were 42 students. Collecting odd semester grades, then doing a normality test, the researcher determines a random sample as a sampling technique. Tests were used to collect data. Analysis of data using descriptive analysis and t-test. The results of the study based on the results of the Paired Sample T-test test obtained a t score of 9.376> t table which is 1306, and the probability value of sig. (2-tailed) 0.000 <0.05 so that it can be inferred that Ha is accepted and Ho is rejected which shows that there is a significant effect of the Al-Barqy method on the ability to read the Qur’an to students at MDA Nurul Ihsan Mudiak Lolo Barat, Sungai Pagu District, South Solok Regency.
Analisis Rasio Keuangan Untuk Mengukur Kinerja Keuangan Studi Pada PT. Telekomunikasi Indonesia Tbk Periode 2017-2021
Authors: Isma Susanti  , Kurniaty Kurniaty  , Abdurrahim Abdurrahim  
Published: August 2024

This study aims to analyze: (1) to evaluate the financial performance of PT Telkom Indonesia Tbk from 2017 to 2021 using various financial ratios. The financial ratios to be used include liquidity ratios, solvency ratios, activity ratios, and profitability ratios.
The design of this study uses a quantitative descriptive approach, which means that the data obtained will be analyzed statistically to provide an overview of the company's financial condition. The survey research method was used to collect financial data from PT Telkom Indonesia Tbk.
The results of the study show: that the financial performance of PT Telkom Indonesia Tbk for the 2017-2021 period based on ratio analysis (1) the calculation of the liquidity ratio (current ratio and quick ratio) is said to be not good. (2) solvency ratios, such as (debt to asset ratio) are said to be not good, while (debt to equity ratio) can be said to be good. (3) Activity ratios, such as inventory turnover, are good. (4) profitability ratios, such as (return on equity and return on investment) can be said to be not good.
Pengendalian Persediaan Bahan Baku Batu Bara Menggunakan Metode Min-Max Di PT. XYZ
Authors: Heru Winarno  , Syahrul M Dhani  
Published: August 2024

Inventory is an important factor in carrying out a production. Many companies experience problems in terms of inventory control, one example is inventory scarcity. The purpose of this study is to optimize the need for goods so that the company will not experience problems with inventory shortages or inventory buildup. This study uses the Min-Max method by collecting data in the form of inventory of goods needs, ordering costs, and storage costs. The result of this study is that the safety stock value of 80,887-tons is useful for protecting and anticipating inventory shortages, so companies must be on guard when they are at that value. Then, the Reorder Point value was obtained at 108,165 tons. Furthermore, the value of the Minimum Inventory is 269,879-tons and the Maximum Inventory is 378,044-tons so that companies are not recommended to have more inventory than that value.