bluuebunny/crossref_metadata_2025_split huggingface dataset:
Broad Spectrum of Skeletal Malformation Complex in Patients with Cleidocranial Dysplasia Syndrome: Radiographic and Tomographic Study
Authors: Kaissi Ali Al , Chehida Farid Ben , Kenis Vladimir , Ganger Rudolf , Radler Christof , Hofstaetter Jochen G. , Klaushofer Klaus , Grill Franz 
Published: August 2013

PurposeCleidocranial dysplasia is an autosomal dominant disorder characterized by defective ossification of the intramembraneous ossification (primarily the clavicles, cranium, and pelvis), and it is caused by mutations in the RUNX2 gene that is responsible for osteoblast differentiation. Spine deformities were of progressive nature and considered to be the major orthopedic abnormalities encountered in our practice in patients with cleidocranial dysplasia. We aimed to further delineate the underlying spine pathology and its etiological understanding. Extraspinal deformities were dealt with respectively.Material and MethodsIn this paper, we describe 7 patients who were consistent with the phenotypic and the genotypic characterization of cleidocranial dysplasia. Reformatted computed tomography (CT) scans have been applied in several instances to further understand the underlying pathology of progressive spine tilting. Radiographs were sufficient to illustrate other skeletal malformations.ResultsAnatomical survey demonstrates that a broad spectrum of frequently unrecognized orthopedic aberrations were encountered. We believe that torticollis has evolved in connection with the persistence of synchondrosis of the skull base and the upper cervical spine and these are strongly correlated to the well-known pathology of posterior occipital synchondrosis. Similarly, scoliosis and kyphoscoliosis resulted from the pathologic aberration of the cartilaginous stage of disrupted embryological development. All our results are discussed for the first time. Coxa vara, patellar dysplasia, and genu valgum were observed as extraspinal deformities.ConclusionThis paper includes for the first time the anatomical analysis of the malformation complex of the craniocervical and the entire spine in patients with cleidocranial dysplasia. Reformatted CT scan was the modality of choice. We were able to illustrate that the persistence of skull base and the cervical spine synchondrosis were correlated with the pathological mechanism of the posterior occipital synchondrosis. Therefore, injuries to the craniocervical region in these patients might lead to a wide range of dreadful complications, ranging from complete atlanto-occipital or atlanto-axial dislocation to nondisplaced occipital condyle avulsion fractures with the possibility of morbid and or mortal outcome. On the other hand, the persistence of a cartilaginous spine was the reason behind the progressive spine tilting. This pathological form can be considered as a notoriously unpredictable malformation complex. The value of presenting these patients is to demonsterate that the genotype is not a precise index to assess the severity and the natural history of the phenotype.
Layout Design for a Low Capacity Manufacturing Line: A Case Study
Authors: De Carlo Filippo , Arleo Maria Antonietta , Borgia Orlando , Tucci Mario 
Published: August 2013

The layout re-arrangement of fashion production lines realizing many small batches is rarely deployed according to well-known engineering procedures. In fact, it would often appear too complex to call a plant engineer for the proper layout design of such small production lines. Rather, it is preferred to apply empirical methodologies when considering, generally, factory know-how, general business needs, safety requirements, and so on. In the present work, the results of a fashion manufacturing line re-layout were compared by analysing the current situation with the solutions provided by a “homemade” company design, both through a systematic layout planning approach and a broader lean reengineering activity. In order to evaluate the effectiveness of each solution, the different alternatives were compared with the help of a discrete event simulator, analysing productivity, transportation times and costs. The result of the case study showed a slight advantage with the lean approach in considering such efficiency indicators. In addition, the lean production methods allowed the designers to identify some inefficiencies that other approaches could not see, since the latter did not focus on production in a holistic way.
Group Investigation in Music Instruction: A Pedagogical Scenario
Authors: Andrews Bernard W. 
Published: August 2013

Group investigation is a teaching strategy that requires students to work in small groups and solve problems by reaching a consensus or solution. Involvement in the investigative process enables a teacher to provide an environment which alleviates conflict and facilitates cooperation. Further, the quality of the solution is higher when reached through consensus. The students are positively motivated to learn and behavioral skills are expanded.
In this paper, the writer examines the history and effectiveness of group investigation since its inception as a teaching strategy by Herbert Thelen. Based upon this analysis and upon formative trials in varied classroom settings, he postulates how the strategy can be utilized by music educators in school and university settings.
Kitsch, Camp, and Opera: Der Rosenkavalier
Authors: Le Tourneau Gary 
Published: August 2013

In her celebrated essay, "Notes on Camp," Susan Sontag identifies Richard Strauss’s most famous opera, Der Rosenkavalier as forming part of the canon of "camp." What is it about this work and its relationship to fin-de-siècle Vienna which gives it over to the "camp" aesthetic?
In this article, the author examines the essence of the style known as camp, as derived from kitsch, another mode of "failed seriousness." Central to this investigation is the manner in which certain aesthetic objects can inhabit the realms of "high" or "serious" art and also that of popular culture. Hermann Broch, Theodor Adorno, and others suggest that kitsch is a parasitic ingredient in bourgeois culture and that this element can invade and "negate" an aesthetic object or experience. The historical imperatives found in romantic opera, bourgeois culture, and marginalized groups form an important element in defining the creations of modernist culture.
Part of our understanding of what constitutes "serious" art has at its centre ways of maintaining autonomy and refusing the prospect of "negating" itself. One way of experiencing and examining those works which "refuse the burden of autonomy" is through the categories of questionable or marginal sensibilities, in this case: kitsch and camp.
Der Rosenkavalier, with its fawning tribute to eighteenth-century Vienna, overt homage to Mozart, and its heralding of the composer's withdrawal from the avant-garde, proves to be a superb example of alternative sensibilities.
Les femmes musiciennes sous les Bourbon d’après les documents inédits de Marie Bobillier
Authors: La France Albert 
Published: August 2013

À sa mort en 1918, Marie Bobillier (pseud. Michel Brenet) a laissé au Département des manuscrits de la Bibliothèque nationale à Paris un nombre impressionnant de notes, de citations et de relevés qu’elle avait accumulés au cours de sa carrière et qui, pour la plupart, demeurent inédits. Dans un dépouillement de ces volumes, l’auteur a extrait les citations, les rapports et les commentaires des auteurs des trois derniers siècles, tous sous le thème « femmes musiciennes ». Il en résulte un éventail assez étonnant des activités musicales des femmes de l’ancien régime sous les rois Bourbon, une espèce de sondage du passé à partir duquel tirer quelques conclusions plus éclairées. Malheureusement, le travail n’a servi qu’à confirmer ce que d’autres ont déjà conclu, à savoir que les femmes des XVIIe et XVIIIe siècles n’avaient qu’un rôle secondaire en musique, tout comme dans les autres aspects de la société, soit artistique, politique ou social. Il faudra attendre le XXe siècle pour que les femmes puissent commencer à prendre leur juste place dans les rangs de la profession musicale.
Une femme musicienne dans un monde masculin : la voix de Begum Akhtar
Authors: Burckhardt Qureshi Regula 
Published: August 2013

L’article situe la vie de musicienne d’une grande chanteuse dont la carrière va du milieu féodal et colonial des cours et des salons jusqu’aux scènes fréquentées par la classe moyenne urbaine d’une Inde indépendante. On y retrouve la question habituellement problématique de l’identité sociale de cette musicienne héréditaire, qui est le corollaire inévitable de l’association entre hommes et interprètes, mais aussi la condition essentielle à l’apprentissage et à la pratique de l’art de la musique. Comment Begum Akhtar a rapidement acquis une réputation en musique grâce à l’appui des nobles, comment elle est « passée » dans le monde respectable du mariage, et comment elle a redéfini son art et sa personne, émergeant comme l’idole nationale de la culture musicale de cour de l’Inde — c’est seulement dans les marges que l’on peut voir tous ces aspects, et ce par le biais d’un kaléidoscope de sources positionnées et de l’expression musicale stylisée d’une artiste dépendante des hommes mais qui a aussi créé des liens musicaux avec des femmes (incluant l’auteure).
Figures du mélodrame dans les écritures d’aujourd’hui
Authors: Ryngaert Jean-Pierre 
Published: August 2013

Il est possible de déceler des traces de « genres » dramatiques dans certains textes contemporains. L’auteur rappelle donc les figures caractéristiques du mélodrame historique et analyse la présence du pathétique dans certaines fables de textes dramatiques québécois d’aujourd’hui. L’auteur se réfère à plusieurs auteurs dans cette perspective (Daniel Danis, Michel Marc Bouchard, Wajdi Mouawad). Le mélodrame s’avère un genre qui s’écarte des idées reçues et qui a le mérite d’autoriser l’expression des sentiments refoulés. Est-ce une des raisons de l’intérêt des spectateurs français pour ces fictions « loin de chez eux » ?
Pesticides present in migrant farmworker housing in North Carolina
Authors: Arcury Thomas A. , Lu Chensheng , Chen Haiying , Quandt Sara A. 
Published: August 2013

AbstractBackgroundMigrant farmworkers are exposed to pesticides at work. Housing provided to migrant farmworkers may also expose them to pesticides, increasing their health risks. This analysis (1) describes the presence of organophosphorous (OP) and pyrethroid pesticides in North Carolina migrant farmworker houses, and (2) delineates associations of farmworker camp characteristics with pesticide detection and concentration.MethodsIn 2010, 186 migrant farmworkers camps in NC were recruited (participation rate of 82.3%); pesticide wipe samples for 176 houses were analyzed. Tobacco is the predominant hand‐harvested crop in this region. Two farmworkers per camp completed interviews; a third assisted with a housing inspection. Gas chromatography–mass spectrometry was used to detect OP and pyrethroid pesticides. Covariates of pesticide detection and concentration were determined with ANOVA and Tobit regression.ResultsOPs were found in 166 of 176 houses (average of 2.4/house); pyrethroids were found in 171 houses (average of 4.3/house). The number of different OPs detected in each camp and concentrations of these OPs were not associated with camp and housing characteristics. The number of different pyrethroids detected in each camp and concentrations of these pyrethroids were associated with camps having residents with H2‐A visas, a posted North Carolina Department of Labor Certificate of Inspection, no barracks, fewer residents, no bedroom weather protection or floor violations, and no roaches.ConclusionsFarmworkers are exposed to pesticides where they live. Policy on removing pesticides from farmworker houses is needed. Reducing pesticides in farmworker houses will reduce one health risk confronted by this vulnerable population. Am. J. Ind. Med. 57:312–322, 2014. © 2013 Wiley Periodicals, Inc.
Nucleus Rostrolateralis: An Expansion of the Epithalamus in Some Actinopterygii
Authors: Saidel William M. 
Published: August 2013

ABSTRACTThe diencephalic nucleus rostrolateralis (RL) in the African butterfly fish (Pantodon buchholzi) is a brain nucleus identified in fewer than a dozen of the ∼25,000 species of actinopterygian fishes. Located in the rostrolateral diencephalon, this nucleus in Pantodon receives direct and indirect visual input from the superior visual field. Its lack of precedent or consistent phylogenetic expression creates a difficulty in interpreting the functional role of this nucleus within the visual system. By tracing experiments, RL was found to be afferent to nucleus interpeduncularis (IP) and the target of cells from the subpallium of the telencephalon. RL is a component of a descending telencephalic pathway involved in at least one behavior at the intersection of limbic and somatic activities—feeding. The parallelism between the ventral telencephalon—RL—IP and the limbic/striatal—habenula—IP pathway (the dorsal diencephalic conduction system, DDCS) suggests that RL is a component within the DDCS. Moreover, the hodological connections of RL suggest that RL is likely a hypertrophy of the lateral habenula. Anat Rec, 296:1594–1602, 2013. © 2013 Wiley Periodicals, Inc.
Interactive deformation and cutting simulation directly using patient‐specific volumetric images
Authors: Li Shuai , Zhao Qinping , Wang Shengfa , Hao Aimin , Qin Hong 
Published: August 2013

ABSTRACTThis paper systematically advocates an interactive volumetric image manipulation framework, which can enable the rapid deployment and instant utility of patient‐specific medical images in virtual surgery simulation while requiring little user involvement. We seamlessly integrate multiple technical elements to synchronously accommodate physics‐plausible simulation and high‐fidelity anatomical structures visualization. Given a volumetric image, in a user‐transparent way, we build a proxy to represent the geometrical structure and encode its physical state without the need of explicit 3‐D reconstruction. On the basis of the dynamic update of the proxy, we simulate large‐scale deformation, arbitrary cutting, and accompanying collision response driven by a non‐linear finite element method. By resorting to the upsampling of the sparse displacement field resulted from non‐linear finite element simulation, the cut/deformed volumetric image can evolve naturally and serves as a time‐varying 3‐D texture to expedite direct volume rendering. Moreover, our entire framework is built upon CUDA (Beihang University, Beijing, China) and thus can achieve interactive performance even on a commodity laptop. The implementation details, timing statistics, and physical behavior measurements have shown its practicality, efficiency, and robustness. Copyright © 2013 John Wiley & Sons, Ltd.
Discovery and Biological Activity of New Chondramides from Chondromyces sp.
Authors: Herrmann Jennifer , Hüttel Stephan , Müller Rolf 
Published: August 2013

AbstractMyxobacteria have proven to be highly valuable sources of natural products, as they produce a variety of secondary metabolites with unique structures and often new modes of action. In this study, high‐content screening is demonstrated to be a convenient tool for bioactivity‐guided isolation of natural products from crude bacterial extracts. By the application of focused, image‐based screens we were able to identify over 30 novel chondramide derivatives from Chondromyces sp. MSr9030, some of which were present in only minute amounts. These cyclic depsipeptides were shown to target actin filaments with a similar binding mode to that of the mushroom toxin phalloidin. Fermentations of the myxobacterial strain were carried out under improved cultivation conditions, and supplementation of the culture broth with potassium bromide afforded the production of brominated analogues that are superior (in terms of biological activity) to all chondramides described to date. Initial biological profiling of 11 new derivatives in comparison to the reference compounds (chondramides A–C) showed that bromo‐chondramide C3 and propionyl‐bromo‐chondramide C3 are the most active in cell‐based studies, with GI50 values on human cancer cell lines in the low nanomolar range. Given that these brominated C3 analogues were also less potent on noncancerous human cells (by a factor of 2 to 4 in comparison to cancer cell lines), our results can aid further structure–activity relationship‐guided development of chondramides, either as molecular probes or pharmaceutical agents.
Effect of leptin on the gluconeogenesis in calf hepatocytes cultured in vitro
Authors: Li Yu , Li Xiaobing , Song Yuxiang , Shi Xiaoxia , Ding Hongyan , Yang Wentao , Liu Zhaoxi , Chen Hui , Li Xinwei , Wang Jianguo , Liu Guowen , Wang Zhe 
Published: August 2013

AbstractWe have investigated the effect of leptin on gluconeogenesis in the liver. Hepatocytes were cultured and treated with 0, 2.5, 5, 10, 50, 100 ng/mL of leptin in groups I, II, III, IV, V, and VI, respectively. mRNA expression and enzyme activity of pyruvate carboxylase and phosphoenolpyruvate carboxykinase were determined by real‐time fluorescence quantitative RT‐PCR and biochemical kits, respectively. Compared with group I, mRNA expression of pyruvate carboxylase and phosphoenolpyruvate carboxykinase in groups III, IV, V, and VI were significantly lower (P < 0.01). Pyruvate carboxylase and phosphoenolpyruvate carboxykinase enzyme activity decreased significantly (P < 0.05) when leptin concentration exceeded 5 and 10 ng/mL, respectively. These results indicate that leptin markedly downregulated mRNA expression and enzyme activity of pyruvate carboxylase and phosphoenolpyruvate carboxykinase in hepatocytes, which suggests that high concentrations of LP inhibit hepatocyte gluconeogenesis, thus making negative energy balance more serious.
A novel recombinant Salmonella vaccine enhances the innate immunity of NK cells against acute myeloid leukaemia cells Kasumi‐1 in vitro
Authors: Zhang Bei , Liu Yuan , Wang Xiuju , Jiang Ling , Lu Zhigang , Zhang Xing , Li Kunpeng , Hu Haiyan 
Published: August 2013

AbstractMinor histocompatibility antigen HA‐1‐specific cytotoxic lymphocyte (CTL) clones have apparent anti‐leukaemic efficacy, and the AML/ETO gene is a special fusion gene in leukaemic cells. Thus, we hypothesised that a vaccine targeting HA‐1 and AML/ETO could stimulate NK cells to target leukaemia cells. Furthermore, we packaged the vaccine using attenuated Salmonella to enhance its immuno‐activity. Expression of the NK cell‐activating ligand ULBP2 was notably elevated upon packaging in a co‐recombinant group. An AML/ETO single plasmid gave the weakest vaccine. The level of miR‐182, which targets ULBP2, significantly decreased with increasing IFN‐γ and granzyme B in a co‐recombinant group. In summary, DNA vaccines including AML/ETO and HA‐1 fragments significantly enhance the innate immunity of NK cells in vitro.
Interaction between optineurin and the bZIP transcription factor NRL
Authors: Wang Chunxia , Hosono Katsuhiro , Ohtsubo Masafumi , Ohishi Kentaro , Gao Jie , Nakanishi Nobuo , Hikoya Akiko , Sato Miho , Hotta Yoshihiro , Minoshima Shinsei 
Published: August 2013

AbstractAlthough the gene encoding optineurin (OPTN) is a causative gene for glaucoma and amyotrophic lateral sclerosis, it is ubiquitously expressed in all body tissues, including the retina. To study the function of OPTN in retinal ganglion cells as well as the whole retina, we previously isolated OPTN‐interacting proteins and identified the gene encoding the bZIP transcription factor neural retina leucine zipper (NRL), which is a causative gene for retinitis pigmentosa. Herein, we investigated the binding between OPTN and NRL proteins in HeLaS3 cells. Co‐expression of HA‐tagged NRL and FLAG‐tagged OPTN in HeLaS3 cells followed by immunoprecipitation and Western blotting with anti‐tag antibodies demonstrated the binding of these proteins in HeLaS3 cells, which was confirmed by proximity ligation assay. NRL is the first OPTN‐binding protein to show eye‐specific expression. A series of partial‐deletion OPTN plasmids demonstrated that the tail region (423–577 amino acids [aa]) of OPTN was necessary for binding with NRL. Immunostaining showed that Optn (rat homologue of OPTN) was expressed in rat photoreceptors and localised in the cytoplasm of photoreceptor cells. This is a novel demonstration of Optn expression in photoreceptor cells. OPTN was not detected in photoreceptor nuclei under our experimental conditions. Further analyses are necessary to elucidate the function of OPTN and the significance of its possible binding with NRL in photoreceptor cells.
Gadolinium(III)‐Hydroxy Ladders Trapped in Succinate Frameworks with Optimized Magnetocaloric Effect
Authors: Chen Yan‐Cong , Guo Fu‐Sheng , Zheng Yan‐Zhen , Liu Jun‐Liang , Leng Ji‐Dong , Tarasenko Róbert , Orendáč Martin , Prokleška Jan , Sechovský Vladimír , Tong Ming‐Liang 
Published: August 2013

AbstractTwo kinds of inorganic gadolinium(III)‐hydroxy “ladders”, [2×n] and [3×n], were successfully trapped in succinate (suc) coordination polymers, [Gd2(OH)2(suc)2(H2O)]n⋅ 2n H2O (1) and [Gd6(OH)8(suc)5(H2O)2]n⋅4n H2O (2), respectively. Such coordination polymers could be regarded as alternating inorganic–organic hybrid materials with relatively high density. Magnetic and heat capacity studies reveal a large cryogenic magnetocaloric effect (MCE) in both compounds, namely (ΔH=70 kG) 42.8 J kg−1 K−1 for complex 1 and 48.0 J kg−1 K−1 for complex 2. The effect of the high density is evident, which gives very large volumetric MCEs up to 120 and 144 mJ cm−3 K−1 for complexes 1 and 2, respectively.
Heteroleptic Alkyl and Amide Iminoanilide Alkaline Earth and Divalent Rare Earth Complexes for the Catalysis of Hydrophosphination and (Cyclo)Hydroamination Reactions
Authors: Liu Bo , Roisnel Thierry , Carpentier Jean‐François , Sarazin Yann 
Published: August 2013

Abstract[{N^N}M(X)(thf)n] alkyl (X=CH(SiMe3)2) and amide (X=N(SiMe3)2) complexes of alkaline earths (M=Ca, Sr, Ba) and divalent rare earths (YbII and EuII) bearing an iminoanilide ligand ({N^N}−) are presented. Remarkably, these complexes proved to be kinetically stable in solution. X‐ray diffraction studies allowed us to establish size–structure trends. Except for one case of oxidation with [{N^N}YbII{N(SiMe3)2}(thf)], all these complexes are stable under the catalytic conditions and constitute effective precatalysts for the cyclohydroamination of terminal aminoalkenes and the intermolecular hydroamination and intermolecular hydrophosphination of activated alkenes. Metals with equal sizes across alkaline earth and rare earth families display almost identical apparent catalytic activity and selectivity. Hydrocarbyl complexes are much better catalyst precursors than their amido analogues. In the case of cyclohydroamination, the apparent activity decreases with metal size: Ca>Sr>Ba, and the kinetic rate law agrees with RCHA=k[precatalyst]1[aminoalkene]1. The intermolecular hydroamination and hydrophosphination of styrene are anti‐Markovnikov regiospecific. In both cases, the apparent activity increases with the ionic radius (Ca<Sr<Ba) but the rate laws are different, and obey RHA=k[styrene]1[amine]1[precatalyst]1 and RHP=k[styrene]1[HPPh2]0[precatalyst]1, respectively. Mechanisms compatible with the rate laws and kinetic isotopic effects are proposed. [{N^N}Ba{N(SiMe3)2}(thf)2] (3) and [{N^N}Ba{CH(SiMe3)2}(thf)2] (10) are the first efficient Ba‐based precatalysts for intermolecular hydroamination and hydrophosphination, and display activity values that are above those reported so far. The potential of the precatalysts for CN and CP bond formation is detailed and a rare cyclohydroamination–intermolecular hydroamination “domino” sequence is presented.