bluuebunny/crossref_metadata_2025_split huggingface dataset:
Preparation and properties of melt‐blended polylactic acid/polyethylene glycol‐modified silica nanocomposites
Authors: Lai Sun‐Mou , Chen Jhong‐Ren , Han Jin‐Lin , Yu Yi‐Fei , Lai Hui‐Yu 
Published: March 2013

AbstractOne commercial type of fumed silica modified with methoxy polyethylene glycol (mPEG) plasticizer was incorporated into polylactic acid (PLA) biobased polymer to improve its performance. The modification on silica was confirmed through Fourier transform infrared spectra, nuclear magnetic resonance, and TGA assessments. The grafting percentage of mPEG onto silica was about 19.8 wt %. Transmission electron microscope revealed a similar degree of dispersion for control silica and modified silica‐filled PLA nanocomposites. Not much difference in the glass transition temperatures at various silica contents was found for PLA/control silica systems from the differential scanning calorimetry measurement, but the glass transition temperature of PLA/modified silica nanocomposite at 10 phr of modified silica showed up to 11°C decrement. It was suggested that the mPEG plasticizer efficiently plasticized the PLA matrix through the enhanced segmental mobility of PLA chains. Young's modulus of PLA was about 2133 ± 53 MPa, and the value for the nanocomposite increased to 2547 ± 54 MPa at 10 of phr control silica mainly due to the reinforcing effect from nanoparticles. For modified silica, Young's modulus decreased at various silica contents. The elongation at break for modified silica‐filled cases was higher than that of control silica‐filled cases. These results were attributed to the plasticizing effect of surface modifier. Optical transmittance for pristine PLA was generally in a similar order as PLA/control silica and modified silica cases at various silica contents. The results agreed with the morphology observation as well. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci., 2013
Synthesis of Privileged Scaffolds by Using Diversity‐Oriented Synthesis
Authors: Surakanti Ramu , Sanivarapu Sumalatha , Thulluri Chiranjeevi , Iyer Pravin S. , Tangirala Raghuram S. , Gundla Rambabu , Addepally Uma , Murthy Y. L. N. , Velide Lakshmi , Sen Subhabrata 
Published: March 2013

AbstractAn elegant reagent‐controlled strategy has been developed for the generation of a diverse range of biologically active scaffolds from a chiral bicyclic lactam. Reduction of the chiral lactam with LAH or alkylation with LHMDS to trigger different cyclization reactions have been shown to generate privileged scaffolds, such as pyrrolidines, indolines, and cyclotryptamines. Their amenability to substitution allows us to create various compound libraries by using these scaffolds. In silico studies were used to estimate the drug‐like properties of these compounds. Selected compounds were subjected to anticancer screening by using three different cell lines. In addition, all these compounds were subjected to antibacterial screening to gauge the spectrum of biological activity that was conferred by our DOS methodology. Gratifyingly, with no additional iterative cycles, our method directly generated anticancer compounds with potency at low nanomolar concentrations, as represented by spiroindoline 14.
A Top‐Down Synthesis Route to Ultrasmall Multifunctional Gd‐Based Silica Nanoparticles for Theranostic Applications
Authors: Mignot Anna , Truillet Charles , Lux François , Sancey Lucie , Louis Cédric , Denat Franck , Boschetti Frédéric , Bocher Laura , Gloter Alexandre , Stéphan Odile , Antoine Rodolphe , Dugourd Philippe , Luneau Dominique , Novitchi Ghenadie , Figueiredo Leandro Carlos , de Morais Paulo Cesar , Bonneviot Laurent , Albela Belen , Ribot François , Van Lokeren Luk , Déchamps‐Olivier Isabelle , Chuburu Françoise , Lemercier Gilles , Villiers Christian , Marche Patrice N. , Le Duc Géraldine , Roux Stéphane , Tillement Olivier , Perriat Pascal 
Published: March 2013

AbstractNew, ultrasmall nanoparticles with sizes below 5 nm have been obtained. These small rigid platforms (SRP) are composed of a polysiloxane matrix with DOTAGA (1,4,7,10‐tetraazacyclododecane‐1‐glutaric anhydride‐4,7,10‐triacetic acid)–Gd3+ chelates on their surface. They have been synthesised by an original top‐down process: 1) formation of a gadolinium oxide Gd2O3 core, 2) encapsulation in a polysiloxane shell grafted with DOTAGA ligands, 3) dissolution of the gadolinium oxide core due to chelation of Gd3+ by DOTAGA ligands and 4) polysiloxane fragmentation. These nanoparticles have been fully characterised using photon correlation spectroscopy (PCS), transmission electron microscopy (TEM), a superconducting quantum interference device (SQUID) and electron paramagnetic resonance (EPR) to demonstrate the dissolution of the oxide core and by inductively coupled plasma mass spectrometry (ICP‐MS), mass spectrometry, fluorescence spectroscopy, 29Si solid‐state NMR, 1H NMR and diffusion ordered spectroscopy (DOSY) to determine the nanoparticle composition. Relaxivity measurements gave a longitudinal relaxivity r1 of 11.9 s−1 mM−1 per Gd at 60 MHz. Finally, potentiometric titrations showed that Gd3+ is strongly chelated to DOTAGA (complexation constant logβ110=24.78) and cellular tests confirmed the that nanoconstructs had a very low toxicity. Moreover, SRPs are excreted from the body by renal clearance. Their efficiency as contrast agents for MRI has been proved and they are promising candidates as sensitising agents for image‐guided radiotherapy.
Comparative Study of Phosphine and N‐Heterocyclic Carbene Stabilized Group 13 Adducts [L(EH3)] and [L2(E2Hn)]
Authors: Holzmann Nicole , Stasch Andreas , Jones Cameron , Frenking Gernot 
Published: March 2013

AbstractQuantum chemical calculations using density functional theory at the BP86/TZ2P level have been carried out to determine the geometries and stabilities of Group 13 adducts [(PMe3)(EH3)] and [(PMe3)2(E2Hn)] (E=B–In; n=4, 2, 0). The optimized geometries exhibit, in most cases, similar features to those of related adducts [(NHCMe)(EH3)] and [(NHCMe)2(E2Hn)] with a few exceptions that can be explained by the different donor strengths of the ligands. The calculations show that the carbene ligand L=NHCMe (:C(NMeCH)2) is a significantly stronger donor than L=PMe3. The equilibrium geometries of [L(EH3)] possess, in all cases, a pyramidal structure, whereas the complexes [L2(E2H4)] always have an antiperiplanar arrangement of the ligands L. The phosphine ligands in [(PMe3)2(B2H2)], which has Cs symmetry, are in the same plane as the B2H2 moiety, whereas the heavier homologues [(PMe3)2(E2H2)] (E=Al, Ga, In) have Ci symmetry in which the ligands bind side‐on to the E2H2 acceptor. This is in contrast to the [(NHCMe)2(E2H2)] adducts for which the NHCMe donor always binds in the same plane as E2H2 except for the indium complex [(NHCMe)2(In2H2)], which exhibits side‐on bonding. The boron complexes [L2(B2)] (L=PMe3 and NHCMe) possess a linear arrangement of the LBBL moiety, which has a BB triple bond. The heavier homologues [L2(E2)] have antiperiplanar arrangements of the LEEL moieties, except for [(PMe3)2(In2)], which has a twisted structure in which the PInInP torsion angle is 123.0°. The structural features of the complexes [L(EH3)] and [L2(E2Hn)] can be explained in terms of donor–acceptor interactions between the donors L and the acceptors EH3 and E2Hn, which have been analyzed quantitatively by using the energy decomposition analysis (EDA) method. The calculations predict that the hydrogenation reaction of the dimeric magnesium(I) compound L′MgMgL′ with the complexes [L(EH3)] is energetically more favorable for L=PMe3 than for NHCMe.
On the Use of Amine–Borane Complexes To Synthesize Iron Nanoparticles
Authors: Pelletier Frédéric , Ciuculescu Diana , Mattei Jean‐Gabriel , Lecante Pierre , Casanove Marie‐José , Yaacoub Nader , Greneche Jean‐Marc , Schmitz‐Antoniak Carolin , Amiens Catherine 
Published: March 2013

AbstractThe effectiveness of amine–borane as reducing agent for the synthesis of iron nanoparticles has been investigated. Large (2–4 nm) Fe nanoparticles were obtained from [Fe{N(SiMe3)2}2]. Inclusion of boron in the nanoparticles is clearly evidenced by extended X‐ray absorption fine structure spectroscopy and Mössbauer spectrometry. Furthermore, the reactivity of amine–borane and amino–borane complexes in the presence of pure Fe nanoparticles has been investigated. Dihydrogen evolution was observed in both cases, which suggests the potential of Fe nanoparticles to promote the release of dihydrogen from amine–borane and amino–borane moieties.
Synthesis of Clickable Water‐Soluble Poly(amidoamine) Fullerodendrimers and Their Use for Surface Functionalization of Azido‐Coated Polymer Nanoparticles
Authors: Rousseau Guillaume , Fensterbank Hélène , Baczko Krystyna , Cano Manuel , Stenger Ingrid , Larpent Chantal , Allard Emmanuel 
Published: March 2013

AbstractIn this study, the synthesis of water‐soluble fullerene derivatives bearing on one side a poly(amidoamine) (PAMAM) dendron with peripheral carboxylic groups and an alkyne moiety on the other side is presented. Fullerodendrimers with tert‐butyl ester groups at the periphery were first prepared by treating C60 with unsymmetrical malonates through the use of 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU)/I2 or DBU/CBr4 conditions. The latter led to an unexpected addition of dibromocarbene on C60. The tert‐butyl esters were then cleaved using formic acid and gave the corresponding carboxyfullerene derivatives. The second generation with eight carboxylic groups at the periphery was easily dissolved in water, whereas the first generation with its four carboxylic groups can only be solubilized in a basic medium. These compounds self‐assemble into micelle‐like aggregates probably composed of a cluster of C60 surrounded by a PAMAM shell. The alkyne moiety was then used as a chemical anchor to immobilize in water fullerodendrimers on the surface of azido‐coated polymer nanoparticles by means of the copper(I)‐catalyzed azide and alkyne cycloaddition reaction. At room temperature, this reaction is competing with azido cycloaddition onto the fullerene core. Given the high density of azide anchoring groups on the nanoparticle surface and the size of the fullerodendrimers, unreacted azides are still active and are available for subsequent functional arrangements. This strategy paves the way for the design of functional fullerene‐rich nanomaterials that could be of interest in the field of materials science.
A Comprehensive Study on the Activity and Deactivation of Immobilized Lecitase Ultra in Esterifications of Food Waste Streams to Monoacylglycerols
Authors: Gonçalves Karen M. , Sutili Felipe K. , Júnior Ivaldo I. , Flores Marcella C. , Soter de Mariz e Miranda Leandro , Leal Ivana C. R. , Cordeiro Yraima , Luque Rafael , de Souza Rodrigo Octavio M. Alves 
Published: March 2013

AbstractLecitase Ultra was immobilized on Amberlites XAD2 and XAD4, through physical entrapping under conventional stirring or ultrasound irradiation, and characterized by standard techniques. The resulting immobilized biocatalysts were utilized in the valorization of an acidic food‐derived residue from a palm oil refining process to produce monoacylglycerols from isopropylidene glycerol under batch and continuous flow conditions. Results indicated that the immobilized biocatalysts could moderately convert the food waste residue (max. conversion 50–60 %), exhibiting interesting stability under continuous flow conditions.
Secure and efficient lightweight RFID authentication protocol based on fast tag indexing
Authors: Pang Liaojun , Li Huixian , He Liwei , Alramadhan Ali , Wang Yumin 
Published: March 2013

SUMMARYDuring the radio‐frequency identification authentication process, it is of great significance to quickly find out the target tag from all tags stored in the database, because it affects the authentication performance to a great extent. Most of the existing schemes use the Hash or pseudorandom number generator operation to locate the target tag, but if the number of tags is extremely large, vast Hash or pseudorandom number generator operations may take much time and lower the authentication efficiency. To locate the target tag quickly, the RAP and LADP protocols adopt the simple value comparison method, and the back‐end server can easily find the target tag by directly comparing the received index‐pseudonym value with those stored in the database. This method does improve the authentication performance, but it results that these schemes suffer from the tag tracking attack. Motivated by these concerns, we propose a novel tag indexing method called the two‐layer tag indexing mechanism, and at the same time, we give a lightweight radio‐frequency identification authentication protocol based on it. Analyses show that our scheme can effectively resist the tag tracking attack and is almost as efficient as the RAP and LADP protocols in indexing tags. Copyright © 2013 John Wiley & Sons, Ltd.
Stereoselective Total Synthesis of (–)‐Batzellasides A, B, and C
Authors: Okaki Toru , Fujimura Ryohei , Sekiguchi Masataka , Zhou Dejun , Sugimoto Kenji , Minato Daishiro , Matsuya Yuji , Kato Atsushi , Adachi Isao , Tezuka Yasuhiro , Saporito Ralph A. , Toyooka Naoki 
Published: March 2013

AbstractTotal synthesis of (–)‐L‐batzellasides A, B, and C has been achieved in 13 steps from known lactone 2 in 12.6, 13.2, and 13.8 % overall yields, respectively. The key steps in this synthesis were the stereoselective introduction of an allyl group at the C1 position by acyliminium chemistry and Brown's asymmetric allylation of the corresponding aldehydes to construct a stereocenter on the side chain.
One‐Pot Synthesis of Camalexins and 3,3′‐Biindoles by the Masuda Borylation–Suzuki Arylation (MBSA) Sequence
Authors: Tasch Boris O. A. , Antovic Dragutin , Merkul Eugen , Müller Thomas J. J. 
Published: March 2013

AbstractThe Masuda borylation/Suzuki arylation (MBSA) sequence starting from N‐protected 3‐iodoindoles has successfully been extended to the coupling of five‐membered heterocycles and indoles in the arylation step, which could not be achieved with previously developed MBSA methods. By this approach the one‐pot nature of the method as well as the use of a simple catalyst system has been retained. The applicability of the method has been demonstrated by the facile synthesis of camalexins and 3,3′‐biindoles, compounds of special interest due to their pronounced antifungal, antimicrobial and cytotoxic activities.
Molecularly Imprinted Polypyrrole for DNA Determination
Authors: Ratautaite Vilma , Topkaya Seda Nur , Mikoliunaite Lina , Ozsoz Mehmet , Oztekin Yasemin , Ramanaviciene Almira , Ramanavicius Arunas 
Published: March 2013

AbstractIn this study graphite electrodes modified by a thin DNA‐imprinted polypyrrole layer, which was able to bind specific target‐DNA, are reported. For this aim, electrochemical synthesis of polypyrrole was performed on a pencil graphite electrode by cyclic voltammetry (CV) or by potential pulse sequences (PPS). The modified electrode surface was used for electrochemical determination of target‐DNA by differential pulse voltammetry. According to our best knowledge this is a first report on the application of DNA‐imprinted polymer for the determination of target‐DNA. The results showed that the molecularly imprinted polypyrrole (MIPPy) layer that formed on the carbon electrode surface was sensitive for target‐DNA, while the nonimprinted polypyrrole layer was not sensitive to the same target‐DNA. Comparison of electrodes modified using PPS and CV techniques is presented.
A Nonparametric Test to Detect Quantitative Trait Loci Where the Phenotypic Distribution Differs by Genotypes
Authors: Aschard Hugues , Zaitlen Noah , Tamimi Rulla M. , Lindström Sara , Kraft Peter 
Published: March 2013

ABSTRACTSearching for genetic variants involved in gene‐gene and gene‐environment interactions in large‐scale data raises multiple methodological issues. Many existing methods have focused on the problem of dimensionality, trying to explore the largest number of combinations between risk factors while considering simple interaction models. Despite evidence demonstrating the efficacy of these methods in simulated data, their application in real data has been unsuccessful so far. The classical test of a linear marginal genetic effect has been widely used for agnostic genome‐wide association studies, with the underlying idea that most variants involved in interactions might display marginal effect on the phenotypic mean. Although this approach may allow for the identification of genetic variants involved in interactions in many scenarios, the linear marginal effects of some causal alleles on the phenotypic mean might not be always detectable at genome‐wide significance level. We introduce in this study a general association test for quantitative trait loci that compare the distributions of phenotypic values by genotypic classes as opposed to most standard tests that compare phenotypic means by genotypic classes. Using simulations we show that in presence of interactions, this approach can be more powerful than the standard test of the linear marginal effect, with a gain of power increasing with increasing interaction effect and decreasing frequencies of the interacting exposures. We demonstrate the potential utility of our method on real data by analyzing mammographic density genome‐wide data from the Nurses’ Health Study.
Future change of the potential landslide disasters as evaluated from precipitation data simulated by MRI‐AGCM3.1
Authors: Oku Yuichiro , Nakakita Eiichi 
Published: March 2013

AbstractThe purpose of this study is to evaluate the number of potential landslide disasters in the future due to the effect of climate change in Japan using atmospheric global atmospheric models. To achieve this, two indices of precipitation R1.5 and R72 were adopted for the evaluation of the number of occurrences in the near future and/or in the future. The potential of shallow landslide occurrence will increase 20% at the end of the 21st century compared with present‐day potential, and that of deep‐seated landslides will increase up to 30%. According to statistical analysis of future changes of precipitation indices, significant change to the number of shallow slides was to be found areas across most areas of Japan. As for deep‐seated landslides, however, changes are statistically significant only in western Japan and some areas of the Tohoku region. Copyright © 2013 John Wiley & Sons, Ltd.
Redox‐ and pH‐Responsive Cysteamine‐Modified Poly(aspartic acid) Showing a Reversible Sol–Gel Transition
Authors: Gyarmati Benjámin , Vajna Balázs , Némethy Árpád , László Krisztina , Szilágyi András 
Published: March 2013

AbstractSynthesis and characterization of a pH‐ and redox‐sensitive hydrogel of poly(aspartic acid) are reported. Reversible gelation and dissolution are achieved both in dimethylformamide and in aqueous medium via a thiol‐disulphide interconversion in the side chain of the polymers. Structural changes are confirmed by Raman microscopy and rheological measurements. Injectable aqueous solutions of thiolated poly(aspartic acid) can be converted into mechanically stable gels by oxidation, which can be useful for drug encapsulation and targeted delivery. Reduction‐facilitated release of an entrapped drug from disulphide cross‐linked hydrogels is studied. magnified image
Fabrication of Mussel‐Inspired Highly Adhesive Honeycomb Films Containing Catechol Groups and Their Applications for Substrate‐Independent Porous Templates
Authors: Saito Yuta , Kawano Takahito , Shimomura Masatsugu , Yabu Hiroshi 
Published: March 2013

AbstractPorous surface patterns are used in a wide variety of practical applications. Honeycomb‐patterned porous polymer films are good templates for preparing porous surfaces due to their simple fabrication and the arrangement of pores on the surface. Catechol groups include in adhesive protein of mussels have attracted much attention due to their highly and substrate‐independent adhesive properties. In this paper, highly and substrate‐independent adhesive honeycomb‐patterned porous polymer films are prepared by using amphiphilic copolymer having catechol moieties. Furthermore, porous surface patterns are transferred on various organic or inorganic substrates by wet etching with using adhesive honeycomb films as templates.magnified image
On best rank one approximation of tensors
Authors: Friedland S. , Mehrmann V. , Pajarola R. , Suter S.K. 
Published: March 2013

SUMMARYToday, compact and reduced data representations using low rank data approximation are common to represent high‐dimensional data sets in many application areas as for example, genomics, multimedia, quantum chemistry, social networks, or visualization. To produce such low rank data representations, the input data is typically approximated by the so‐called alternating least squares (ALS) algorithms. However, not all of these ALS algorithms are guaranteed to converge. To address this issue, we suggest a new algorithm for the computation of a best rank one approximation of tensors, called alternating singular value decomposition. This method is based on the computation of maximal singular values and the corresponding singular vectors of matrices. We also introduce a modification for this method and the ALS method, which ensures that alternating iterations will always converge to a semi‐maximal point (a critical point in several vector variables is semi‐maximal if it is maximal with respect to each vector variable, while other vector variables are kept fixed). We present several numerical examples that illustrate the computational performance of the new method in comparison to the ALS method. Copyright © 2013 John Wiley & Sons, Ltd.
A revision of the quality of life‐breast cancer survivors (QOL‐BCS) instrument
Authors: Azuero Andres , Su Xiaogang , McNees Patrick , Meneses Karen 
Published: March 2013

AbstractThe importance of quality of life (QOL) measurement among breast cancer survivors (BCS) is well‐recognized by researchers and clinicians. With data from 427 rural BCS, the authors used a combination of clinical expertise and statistical analysis to revise a 48‐item measure of QOL specific to BCS. The revised 15‐item measure showed adequate psychometric properties and provides the basis for a brief yet comprehensive multidimensional measure of QOL applicable to most BCS. Future work includes fine‐tuning the measurement model and examining its generalizability among non‐rural BCS. © 2013 Wiley Periodicals, Inc. Res Nurs Health 36: 423–434, 2013
Guideline for the prevention of acute nausea and vomiting due to antineoplastic medication in pediatric cancer patients
Authors: Dupuis L. Lee , Boodhan Sabrina , Holdsworth Mark , Robinson Paula D. , Hain Richard , Portwine Carol , O'Shaughnessy Erin , Sung Lillian 
Published: March 2013

AbstractThis guideline provides an approach to the prevention of acute antineoplastic‐induced nausea and vomiting (AINV) in children. It was developed by an international, inter‐professional panel using AGREE and CAN‐IMPLEMENT methods. Evidence‐based interventions that provide optimal AINV control in children receiving antineoplastic agents of high, moderate, low, and minimal emetogenicity are recommended. Recommendations are also made regarding selection of antiemetic agents for children who are unable to receive corticosteroids for AINV control, the role of aprepitant and optimal doses of antiemetic agents. Gaps in the evidence used to support the recommendations were identified. The contribution of this guideline to AINV control in children requires prospective evaluation. Pediatr Blood Cancer 2013; 60: 1073–1082. © 2013 Wiley Periodicals, Inc.