bluuebunny/crossref_metadata_2025_split huggingface dataset:
Palbociclib in Patients With Soft Tissue Sarcoma With CDK4 Amplifications: Results From the Targeted Agent and Profiling Utilization Registry Study
Authors: Schuetze Scott , Rothe Michael , Mangat Pam K. , Garrett-Mayer Elizabeth , Meric-Bernstam Funda , Calfa Carmen J. , Farrington Laura Catherine , Livingston Michael B. , Wentzel Kristopher , Behl Deepti , Kier Yelena , Marr Alissa S. , von Mehren Margaret , Press Joshua Z. , Thota Ramya , Grantham Gina N. , Gregory Abigail , Hinshaw Dominique C. , Halabi Susan , Schilsky Richard L. 
Published: July 2024

PURPOSE Targeted Agent and Profiling Utilization Registry (TAPUR) is a phase II basket trial evaluating the antitumor activity of commercially available targeted agents in patients with advanced cancer and genomic alterations known to be drug targets. Results of a cohort of patients with soft tissue sarcoma with cyclin-dependent kinase 4 ( CDK4) amplification treated with palbociclib are reported. METHODS Eligible patients had measurable disease, Eastern Cooperative Oncology Group performance status 0 to 2, adequate organ function, and no standard treatment options. The primary end point was disease control (DC), defined as objective response (OR) or stable disease (SD) of at least 16+ weeks duration (SD16+) according to RECIST v1.1. The DC rate was estimated with a 90% CI. Secondary end points included OR, progression-free survival (PFS), overall survival (OS), duration of response, duration of SD, and safety. RESULTS Forty-two patients with CDK4 amplification were enrolled. One patient was not evaluable for efficacy. One patient with partial response and 18 with SD16+ were observed for DC and OR rates of 46% (90% CI, 36 to 100) and 2% (95% CI, <1 to 13), respectively. Median PFS was 16 weeks (95% CI, 9 to 28) and median OS was 69 weeks (95% CI, 31 to 111) for evaluable patients. Twenty patients had at least one grade 3 to 4 adverse event (AE) at least possibly related to palbociclib, including alanine aminotransferase increase, anemia, fatigue, hypophosphatemia, leukopenia, neutropenia, and thrombocytopenia. No serious AEs were reported. CONCLUSION Palbociclib met prespecified criteria to declare a signal of antitumor activity in patients with sarcoma and CDK4 amplification.
A Rough Guide to the Oil Archive
Authors: Becker Lukas 
Published: July 2024

Abstract
The omnipresence of petroleum makes it an essential part of a history of the modern world. However, this ubiquity also presents a challenge as to which archival materials historians should use to tell this story. By using material gathered during fieldwork in the Colombian oil city of Barrancabermeja, this article aims to investigate the nature of the oil archive. Situated within the broader field of literature on the history of petroleum and archives, the investigation touches upon records in diverse archives, the urban fabric, and repositories of oil’s history to be found underground. By pinpointing such materials across Barrancabermeja, the article argues that the oil archive is not just found in historical documents but embedded in the landscape, in social practices, in human bodies, and even in the geology of the earth. To understand the deep-seated influence of oil, the article argues for the establishment of an interdisciplinary working group of the oil archive. Faced with the impending challenge of climate change and the long-lasting legacy of the fossil fuel age, such a group could provide evidence for how humanity got to this stage, point to different imaginaries of past and future, and clarify issues surrounding climate justice and responsibility.
FOXC1 and FOXC2 regulate growth plate chondrocyte maturation towards hypertrophy in the embryonic mouse limb skeleton
Authors: Almubarak Asra , Zhang Qiuwan , Zhang Cheng-Hai , Abdelwahab Noor , Kume Tsutomu , Lassar Andrew B. , Berry Fred B. 
Published: July 2024

ABSTRACT
The Forkhead box transcription factors FOXC1 and FOXC2 are expressed in condensing mesenchyme cells at the onset of endochondral ossification. We used the Prx1-cre mouse to ablate Foxc1 and Foxc2 in limb skeletal progenitor cells. Prx1-cre;Foxc1Δ/Δ;Foxc2Δ/Δ limbs were shorter than controls, with worsening phenotypes in distal structures. Cartilage formation and mineralization was severely disrupted in the paws. The radius and tibia were malformed, whereas the fibula and ulna remained unmineralized. Chondrocyte maturation was delayed, with fewer Indian hedgehog-expressing, prehypertrophic chondrocytes forming and a smaller hypertrophic chondrocyte zone. Later, progression out of chondrocyte hypertrophy was slowed, leading to an accumulation of COLX-expressing hypertrophic chondrocytes and formation of a smaller primary ossification center with fewer osteoblast progenitor cells populating this region. Targeting Foxc1 and Foxc2 in hypertrophic chondrocytes with Col10a1-cre also resulted in an expanded hypertrophic chondrocyte zone and smaller primary ossification center. Our findings suggest that FOXC1 and FOXC2 direct chondrocyte maturation towards hypertrophic chondrocyte formation. At later stages, FOXC1 and FOXC2 regulate function in hypertrophic chondrocyte remodeling to allow primary ossification center formation and osteoblast recruitment.
Can Eccentric-Only Resistance Training Decrease Passive Muscle Stiffness While Increasing Size and Strength of Hamstrings?
Authors: KAWAMA RAKI , TAKAHASHI KATSUKI , IKIFUNE HARUKI , TOZAWA HIRONOSHIN , OBATA TAKAFUMI , ITO RYO , HOJO TATSUYA , WAKAHARA TAKU 
Published: July 2024

ABSTRACT

Purpose
Resistance training may be empirically believed to increase passive muscle stiffness. Meanwhile, a recent study showed that the passive stiffness of a specific hamstring muscle acutely decreased after eccentric-only resistance exercise at long muscle lengths with a long contraction duration (LL). To extend this finding, the present study investigated the chronic effects of eccentric-only resistance training with LL at different weekly frequencies on the passive stiffness of the biarticular hamstring muscles.

Methods
Thirty-six healthy young males were assigned into two training groups with two and three weekly sessions (W2 and W3; n = 12, respectively) and a control group (CON; n = 12). The participants in both training groups performed eccentric-only stiff-leg deadlift at 50%–100% of exercise range of motion (0% = upright position) with 5 s per repetition for 10 wk. Before and after the intervention period, the shear moduli of the biarticular hamstring muscles, maximal voluntary isometric torque of knee flexion, and volumes of the individual hamstring muscles were measured.

Results
In W3, the shear modulus of the semimembranosus (−11.4%) significantly decreased, whereas those of the other biarticular muscles did not change. There were no significant changes in the shear moduli of the biarticular hamstring muscles in W2 or CON. The isometric torque (20.3% and 26.2%, respectively) and semimembranosus volume (5.7% and 7.4%, respectively) were significantly increased in W2 and W3.

Conclusions
Passive stiffness of a specific muscle could be chronically decreased when eccentric-only resistance training with LL is performed at a relatively high weekly frequency with a high total training volume. Our training modality may be a promising strategy for decreasing passive muscle stiffness while increasing muscular strength and size.
The role of Gut Microbiota and Probiotics in physical performance of athletes - Literature review
Authors: Skupińska Olga , Wojtczak Karolina , Antczak Joanna , Kajka Anna , Hamerska Julia , Ruta Damian , Bocianiak Bogumił , Hamerska Laura , Lipska Julia , Fenrych Urszula 
Published: July 2024

INTRODUCTION: The human gut microbiota is an extremely diverse and complex ecosystem that inhibits the mucous membranes of the intestines. It is probable that the microbiota, with its capacity to influence the immune system and establish the conditions required for metabolic and structural functions essential for maintaining homeostasis, may significantly affect the health, well-being, and performance of athletes.
PURPOSE: The aim of the study is to present the current state of knowledge about the differences in athletes’ gut microbiota, how these changes affect their physical performance and uncover the mechanisms behind gut microbiota and probiotics in physical performance among population of athletes.

MATERIAL AND METHODS: The following review was conducted using the articles from the Pubmed and Google Scholar databases, employing keywords related to gut microbiota, athletes, physical performance. We collected studies performed on populations of athletes, exploring different sport disciplines.

CONCLUSIONS:
Numerous studies have investigated the gut microbiota of athletes, emphasizing the impact of both training and diet. Athletes' unique dietary regimens, including higher protein or carbohydrates intake, influence their gut microbiome, leading to enhanced performance. These findings uncover that diet diversity correlates with gut diversity, which is linked to metabolic benefits and a lean phenotype. Studies on rugby players, cyclists, and marathoners reveal that certain microbial species, like Prevotella and Veillonella, are more abundant in athletes and play significant roles in nutrient metabolism and exercise recovery. These findings suggest that the interaction between athletic lifestyle and the gut microbiota affects positively the metabolism of the host, by enhancing microbiota diversity, and increasing the abundance of beneficial bacteria.
The impact of Intermittent Fasting on Weight Loss and Metabolic Health - a review of the latest research
Authors: Gonciarz Marta Justyna , Adamiec Dominika Karolina , Dąbrowska Anna , Paduszyńska Natalia , Zaliwska Dominika , Czach Magdalena , Strojny Agnieszka Aleksandra , Kraszkiewicz Adrianna , Kamińska Monika Anna , Do Monika Kienanh 
Published: July 2024

Introduction and purpose

Intermittent fasting (IF) is a dietary pattern that alternates between periods of fasting or reduced caloric intake and periods of unrestricted eating. There are three primary types of IF: Alternate Day Fasting (ADF), Time-Restricted Eating (TRE), and Periodic Fasting (PF). This review article summarizes the impact of IF on weight loss. Additionally, it examines the broader health effects of IF, including its influence on cardiovascular risk, diabetes management, and neurodegenerative diseases.

Description of the state of knowledge

Fasting, the practice of abstaining from or limiting food intake for a specified period, has been a cultural and religious tradition worldwide for centurie. Common IF methods alternating 24-hour periods of fasting with days of eating, TRE restricts eating to specific windows of time each day, and PF includes patterns such as the 5:2 diet, where fasting occurs on two days each week.

Conclusions

The analysis of the review article demonstrates that intermittent fasting (IF) leads to weight loss, aiding in the treatment of obesity. Moreover, IF reduces glycated hemoglobin levels and increases periods of normoglycemia, potentially benefiting diabetes patients. Nonetheless, there is a lack of sufficient research to confirm the safety of IF for diabetics, given the risk of hypoglycemia. Research also indicates that IF positively impacts cardiovascular risk factors by lowering total cholesterol, LDL-C, and triglyceride levels. Additionally, while IF might reduce the risk of certain cancers by addressing obesity, it is not advised for cancer patients due to inadequate scientific evidence. Furthermore, some studies indicate that IF could be advantageous in managing certain neurological diseases.
The Role of Sport in Human Health: Prevention and Treatment of Osteoporosis
Authors: Śliz Justyna , Popławska Natalia Aleksandra , Skorupska Marta , Czeczotka Magdalena Joanna , Woźniak Krzysztof , Martka Martyna Magdalena 
Published: July 2024

Introduction and purpose
Osteoporosis is the most prevalent metabolic bone disease, characterized by diminished bone mineral density, compromised bone microarchitecture, and geometry, culminating in diminished bone strength and susceptibility to fractures. Physical activity posits potential as a preventive measure and therapeutic approach for osteoporosis. The aim of this study was to assess the impact of physical activity on the prevention and treatment of osteoporosis.
Materials and method
In order to curate appropriate sources for this article, a comprehensive search was conducted within the PubMed and Google Scholar databases.
A brief description of the state of knowledge
One of the risk factors for osteoporosis is a lack of physical activity. For this reason, many scientists have decided to conduct some research to determine whether physical activity will have a beneficial impact on both the prevention and treatment of osteoporosis. These studies show that physical activity can benefit people with osteoporosis by improving bone density, balance, strength, and overall physical function. Regular and long-term exercise is essential to maximize these benefits.
Summary
The studies conducted so far provide promising results and confirm the beneficial impact of physical exercises on people with osteoporosis as well as on the prevention of this disease. Exercises should be performed regularly and persistently.
Does Online Fundraising Increase Charitable Giving? A Nationwide Field Experiment on Facebook
Authors: Adena Maja , Hager Anselm 
Published: July 2024

Does online fundraising increase charitable giving? Using the Facebook advertising tool, we implemented a natural field experiment across Germany, randomly assigning almost 8,000 postal codes to Save the Children fundraising videos or to a pure control. We studied changes in the donation revenue and frequency for Save the Children and other charities by postal code. Our geo-randomized design circumvented many difficulties inherent in studies based on click-through data, especially substitution and measurement issues. We found that (i) video fundraising increased donation revenue and frequency to Save the Children during the campaign and in the subsequent five weeks, that (ii) the campaign was profitable for the fundraiser, and that (iii) the effects were similar independent of video content and impression assignment strategy. However, we also found some crowding out of donations to other similar charities or projects. Finally, we demonstrated that click data may be an inappropriate proxy for donations and recommend that managers use careful experimental designs that can plausibly evaluate the effects of advertising on relevant outcomes. This paper was accepted by Yan Chen, behavioral economics and decision analysis. Funding: M. Adena acknowledges financial support from the Deutsche Forschungsgemeinschaft [Grants 417014946 and CRC TRR 190 (Project 280092119)]. Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2020.00596 .
Community Involvement in Onchocerciasis Post-elimination Surveillance in Bududa District, Eastern Uganda: A cross-sectional study
Authors: Khainza Annet Tabitha , Soita David , Okia David , Okello Francis , Matovu Joseph KB , Lubaale Yovani , Byamukama Edson , Okibure Ambrose , Alunyo Jimmy Patrick , Nantale Ritah , Wanume Benon , Ogutu David , Mukunya David , Olupot-Olupot Peter 
Published: July 2024

Background
Globally, there are an estimated 20.9 million cases of onchocerciasis, with Africa bearing the greatest burden. The World Health Organization (WHO) has targeted the disease for elimination by 2030. As of August 2023, there were 15 foci in 37/48 (76%) districts and one city in Uganda that had reached the elimination phase. However, there is a paucity of data on community involvement in post-elimination surveillance (PES) activities. The communities in the post-elimination phase are expected to maintain surveillance, provide health education, refer cases for treatment, and participate in surveillance. However, it is not clear whether this is being done. In this study, we assessed the feasibility of community involvement in post-elimination surveillance activities in Bududa District, Eastern Uganda, to draw key generalisable lessons for similar settings.

Methods
This was a cross-sectional study employing rigorous mixed methods of data collection. We used a semi-structured questionnaire to collect quantitative data on randomly sampled study participants in two sub-countries in the district. Community involvement in post-elimination surveillance (PES) was our dependent variable, measured using Yes or No questions, and our independent variables were measured on different scales. Computations of proportions and associations were done using Stata 15 software. Conversely, qualitative data were collected via focus group discussions (FGDs) for community participants and key informant interviews (KIIs) for local leaders. For the qualitative component, we had 2 FGDs, each consisting of 8 gender-balanced participants per group and 8 KIIs. Qualitative data analyses were done using a robust thematic framework approach, ensuring the reliability and validity of our findings.

Results
A total of 422 participants with a mean age of 51.4 years (SD = 15.8) participated in the study. Community involvement in post-elimination surveillance was low (14%). Factors associated with involvements were district support [Adjusted odd ratio AOR 14, 95 CI = (2.5, 81.7)], seeing black flies in the environment in a week preceding the survey [AOR 8, 95% CI = (1.5, 42.5)], in one month [AOR 3.8, 95% CI = (1.1, 13.2)], and being a community volunteer in the Ivermectin treatment program [AOR 4.3, 95% CI = (1.03, 17.9)]. Lack of funding, poor motivation, poor program sustainability planning, and a lack of drugs at health facilities were key challenges affecting community involvement in post-elimination surveillance.

Conclusion
Community involvement in onchocerciasis post-elimination surveillance activities in Bududa District in Eastern Uganda was low but could be improved by increased district support, funding, community motivation and sensitisation.
Impact of mutations in the mtrR, rpdlVD and rrl genes on azithromycin resistance in Neisseria gonorrhoeae
Authors: Mauffrey Florian , Poncet Fabrice , Jacot Damien , Greub Gilbert , Nordmann Patrice , Blanc Dominique S. 
Published: July 2024

Introduction
Bacterial sexually transmitted infections (STIs) pose a major public health problem. The emergence of antibiotic-resistant strains of Neisseria gonorrhoeae represents a serious threat to successful treatment and epidemiological control. The first extensively drug-resistant (XDR) strains (ceftriaxone-resistant and high-level azithromycin-resistant [HLR AZY]) have been reported.

Aims
To identify molecular mechanisms implicated in azithromycin resistance in strains isolated from patients over a three-year period in a university hospital in Switzerland.

Material and methods
From January 2020 to December 2022, 34 isolates (one per patient) were recovered from samples analyzed at the University Hospital of Lausanne. Eight genes involved in azithromycin resistance were sequenced: mtrR repressor (mtrCDE operon repressor) and his promotor mtrR-pr, rplD gene (L4 ribosomal protein), rplV gene (L22 ribosomal protein) and the four alleles of the rrl gene (23S rRNA).

Results
With a cutoff value of 1 mg/L, 15 isolates were considered as being resistant to azithromycin, whereas the remaining 19 were susceptible. The C2597T mutation in 3 or 4 of the rrl allele confer a medium-level resistance to azithromycin (MIC = 16 mg/L, N = 2). The following mutations were significantly associated with MIC values ≥1 mg/L: the three mutations V125A, A147G, R157Q in the rplD gene (N = 10) and a substitution A->C in the mtrR promotor (N = 9). Specific mutations in the mtrR repressor and its promotor were observed in both susceptible and resistant isolates.

Conclusions
Resistance to azithromycin was explained by the presence of mutations in many different copies of 23S RNA ribosomal genes and their regulatory genes. Other mutations, previously reported to be associated with azithromycin resistance, were documented in both susceptible and resistant isolates, suggesting they play little role, if any, in azithromycin resistance.
Chinese herbal compound preparation Qing-Xin-Jie-Yu granules for intermediate coronary lesions in patients with stable coronary artery disease: Study protocol for a multicenter, randomized, double-blind, placebo-controlled trial
Authors: Chen Luying , Dai Lulu , Xu Jiawei , Duan Lian , Hou Xiaoxia , Zhang Lu , Song Libo , Zhao Fangfang , Jiang Yuerong 
Published: July 2024

Introduction
Despite the available secondary preventive treatments, the management of stable coronary artery disease (SCAD) remains challenging. Intermediate coronary lesion (ICL), defined as luminal stenosis between 50% and 70%, is a key stage of SCAD. However, existing therapeutic strategies are limitated in delaying plaque progression and associated with various adverse effects and economic burdens. Qing-Xin-Jie-Yu Granules (QXJYG) with proven anti-platelet, anti-inflammatory, and lipid-lowering effects may compensate for the drawbacks of current treatments and can be tested as a complementary therapy. Therefore, this study aims to investigate the efficacy and safety of QXJYG in treating ICL, with a particular focus on its impact on myocardial ischemia and plaque progression.

Materials and methods
This is a multicenter, randomized, double-blind, placebo-controlled trial. A total of 120 participants with ICL will be randomly assigned to two groups in a 1:1 ratio. In addition to basic medications, the intervention group will receive QXJYG, while the control group will receive a placebo for over 6 months, followed by a 12-month follow-up. The primary efficacy outcome is computed tomography-derived fractional flow reserve. The secondary outcomes include the degree of coronary stenosis, coronary artery calcification score, Gensini score, Seattle Angina Questionnaire score, high-sensitivity C-reactive protein, matrix metalloproteinase-9, blood lipids, and carotid artery ultrasound parameters. Major adverse cardiovascular events are recorded as endpoints. The safety outcomes include composite events of bleeding, laboratory test results, and adverse events. Clinical visits are scheduled at baseline, every 2 months during the treatment, and after a 12-month follow-up.

Discussion
This trial is anticipated to yield reliable results to verify the efficacy and safety of QXJYG in the treatment of ICL, which will provide novel insights to help address the prevailing therapeutic dilemma of ICL, thereby facilitating for the management of SCAD.

Trial registration
Chinese Clinical Trial Registry, ChiCTR2200059262. Registered on April 27, 2022.
Prevalence of Belching Disorders and Their Characteristics in the General Adult Population
Authors: Fujiwara Yasuhiro , Sawada Akinari , Kobayashi Yumie , Hosomi Shuhei , Otani Koji , Fukunaga Shusei , Ominami Masaki , Taira Koichi , Tanaka Fumio 
Published: July 2024

INTRODUCTION:
Excessive bothersome belching is clinically problematic and the Rome IV classification categorizes belching disorders as gastroduodenal disorders.

METHODS:
A total of 10,000 Japanese adults participated in this web-based survey. We aimed to examine the prevalence of belching disorders and their characteristics.

RESULTS:
Belching disorders were found in 151 (1.5%) adults. The presence of reflux esophagitis, thyroid diseases, gastroesophageal reflux disease, functional dyspepsia, full eaters, or a small or large number of mastication was significantly associated with an increased odds ratio of belching disorders.

DISCUSSION:
A detailed epidemiology of belching disorders in adults was clarified.