bluuebunny/crossref_metadata_2025_split huggingface dataset:
Discourses of minority francophone space: The emergent role of an Acadian cultural center
Authors: Keating Kelle L. 
Published: October 2014

AbstractRecent studies documenting minority linguistic space in urban settings have focused on cities' linguistic landscapes, and external signage is often taken to index linguistic practices within businesses, government offices, and other establishments. To shed light on linguistic practices in culturally significant spaces of this sort, it is helpful to consider social actors' discursive construction of the spaces themselves. This article describes discourses of minority francophone space elicited from members and associates of Moncton, New Brunswick'sCentre culturel Aberdeen. The data are analyzed according to Lefebvre's (1974/1991) conceived, perceived, and lived spaces and Heller & Labrie's (2004) modernizing and globalizing discourses. The present findings demonstrate that, while Aberdeen's conceived space is francophone, other languages are spoken in Aberdeen's perceived space. Participants also describe Aberdeen's lived space as bilingual, mediating between anglophones and francophones. These discourses, coupled with changes in the Centre's charter, suggest an emergent, plural conception of minority francophone space. (Francophone, minority, Canada, Acadian, discourse, social space)*
Developments toward hard X-ray radiography on heavy-ion heated dense plasmas
Authors: Li K. , Borm B. , Hug F. , Khaghani D. , Löher B. , Savran D. , Tahir N. A. , Neumayer P. 
Published: October 2014

AbstractWe have studied the potential of hard X-ray radiography as a diagnostic in high energy density experiments, proposed for the future Facility for Antiproton and Ion Research (FAIR). We present synthetic radiographic images generated from hydrodynamic simulations of the target evolution. The results suggest that high-resolution density measurements can be obtained from powerful hard X-ray sources driven by a PW-class high-energy laser system. Test measurements of a prototype hard X-ray imaging detector for photon energies above 100 keV are presented.
The Exalted Column, the Hejaz Railway and imperial legitimation in late Ottoman Haifa
Authors: TALBOT MICHAEL 
Published: October 2014

ABSTRACT:This article examines the political and social tensions of late Ottoman Haifa through the history of the Hejaz Railway and a particular monument, the ‘Exalted Column’ (Sütūn-u ʿĀlī), a monument erected in 1903 to commemorate the beginning of Ottoman construction on the Haifa railway branch. By first establishing the use of railways and railway architecture as a means of exerting state power in a comparative and local perspective, the railway structures in Haifa are analysed in the context of that city's other monumental buildings. This then leads to a discussion of theSütūn-u ʿĀlīas a celebration of Ottoman authority and modernity, and of the developing Ottoman–German alliance. The symbolism of the column's iconography is shown to reflect a variety of problems that the Ottoman state faced in Haifa at the turn of the twentieth century.
‘[The Irish] find much difficulty in these auxiliaries . . .puttingwillforshallwith the first person’: the decline of first-personshallin Ireland, 1760–1890
Authors: McCAFFERTY KEVIN , AMADOR-MORENO CAROLINA P. 
Published: October 2014

Among prescriptivists, the Irish have long had a reputation for not following the rule requiring a distinction betweenshallwith first-person andwillwith other grammatical subjects. Recent shift towardswillwith all persons in North American English – now also affecting British English – has been attributed to the influence of Irish immigrants. The present study of data from theCorpus of Irish English Correspondence(CORIECOR) finds that Irish English has not always preferredwill. Rather, the present-day situation emerged in Irish English between the late eighteenth and late nineteenth centuries. This important period covers the main language shift from Irish to English, and simplification in the acquisition process may account for the Irish English use ofwill.In eighteenth-century Irish English,shallpredominated. Comparison with other colonial Englishes of the period – US English (Kytö 1991) and Canadian English (Dollinger 2008) – and with north-west British English (Dollinger 2008) shows broadly similar cross-varietal distributions of first-personshallandwill. Irish English shifted rapidly towardswillby the 1880s, but was not unusual in this respect; a similar development took place at the same time in Canadian English, which may indicate a more general trend, at least in colonial Englishes. It is thus doubtful that Irish English influence drove the change towards first-personwill.We suggest the change might be associated with increasing literacy and accompanying colloquialisation (Mair 1997; Biber 2003; Leechet al.2009: 239ff.). As Rissanen (1999: 212) observes, and Dollinger corroborates for north-west British English,willpersisted in regional Englishes after the rise of first-personshallin the standard language. Increased use ofwillmight have been an outcome of wider literacy leading to more written texts, like letters, being produced by members of lower social strata, whose more nonstandard/vernacular usage was thus recorded in writing. There are currently few regional letter corpora for testing this hypothesis more widely. However, we suggest that, in nineteenth-century Ireland, increasing literacy may have helped spread first-personwillas a change from below. The shift to first-personwillthat is apparent in CORIECOR would then result from greater lower-class literacy, and this might be a key to understanding this change in other Englishes too.
Heuristics in primary care for recognition of unreported vision loss in older people: a technology development study
Authors: Wijeyekoon Skanda , Kharicha Kalpa , Iliffe Steve 
Published: October 2014

AimTo evaluate heuristics (rules of thumb) for recognition of undetected vision loss in older patients in primary care.BackgroundVision loss is associated with ageing, and its prevalence is increasing. Visual impairment has a broad impact on health, functioning and well-being. Unrecognised vision loss remains common, and screening interventions have yet to reduce its prevalence. An alternative approach is to enhance practitioners’ skills in recognising undetected vision loss, by having a more detailed picture of those who are likely not to act on vision changes, report symptoms or have eye tests. This paper describes a qualitative technology development study to evaluate heuristics for recognition of undetected vision loss in older patients in primary care.MethodUsing a previous modelling study, two heuristics in the form of mnemonics were developed to aid pattern recognition and allow general practitioners to identify potential cases of unreported vision loss. These heuristics were then analysed with experts.FindingsIt was concluded that their implementation in modern general practice was unsuitable and an alternative solution should be sort.
Distinct soil microbial diversity under long-term organic and conventional farming
Authors: Hartmann Martin , Frey Beat , Mayer Jochen , Mäder Paul , Widmer Franco 
Published: October 2014

AbstractLow-input agricultural systems aim at reducing the use of synthetic fertilizers and pesticides in order to improve sustainable production and ecosystem health. Despite the integral role of the soil microbiome in agricultural production, we still have a limited understanding of the complex response of microbial diversity to organic and conventional farming. Here we report on the structural response of the soil microbiome to more than two decades of different agricultural management in a long-term field experiment using a high-throughput pyrosequencing approach of bacterial and fungal ribosomal markers. Organic farming increased richness, decreased evenness, reduced dispersion and shifted the structure of the soil microbiota when compared with conventionally managed soils under exclusively mineral fertilization. This effect was largely attributed to the use and quality of organic fertilizers, as differences became smaller when conventionally managed soils under an integrated fertilization scheme were examined. The impact of the plant protection regime, characterized by moderate and targeted application of pesticides, was of subordinate importance. Systems not receiving manure harboured a dispersed and functionally versatile community characterized by presumably oligotrophic organisms adapted to nutrient-limited environments. Systems receiving organic fertilizer were characterized by specific microbial guilds known to be involved in degradation of complex organic compounds such as manure and compost. The throughput and resolution of the sequencing approach permitted to detect specific structural shifts at the level of individual microbial taxa that harbours a novel potential for managing the soil environment by means of promoting beneficial and suppressing detrimental organisms.
Inductively guided circuits for ultracold dressed atoms
Authors: Sinuco-León German A. , Burrows Kathryn A. , Arnold Aidan S. , Garraway Barry M. 
Published: October 2014

AbstractRecent progress in optics, atomic physics and material science has paved the way to study quantum effects in ultracold atomic alkali gases confined to non-trivial geometries. Multiply connected traps for cold atoms can be prepared by combining inhomogeneous distributions of DC and radio-frequency electromagnetic fields with optical fields that require complex systems for frequency control and stabilization. Here we propose a flexible and robust scheme that creates closed quasi-one-dimensional guides for ultracold atoms through the ‘dressing’ of hyperfine sublevels of the atomic ground state, where the dressing field is spatially modulated by inductive effects over a micro-engineered conducting loop. Remarkably, for commonly used atomic species (for example, 7Li and 87Rb), the guide operation relies entirely on controlling static and low-frequency fields in the regimes of radio-frequency and microwave frequencies. This novel trapping scheme can be implemented with current technology for micro-fabrication and electronic control.
Functional Phylogenetics Reveals Contributions of Pleiotropic Peptide Action to Ligand-Receptor Coevolution
Authors: Jiang Hongbo , Wei Zhaojun , Nachman Ronald J. , Adams Michael E. , Park Yoonseong 
Published: October 2014

AbstractThe evolution of peptidergic signaling has been accompanied by a significant degree of ligand-receptor coevolution. Closely related clusters of peptide signaling molecules are observed to activate related groups of receptors, implying that genes encoding these ligands may orchestrate an array of functions, a phenomenon known as pleiotropy. Here we examine whether pleiotropic actions of peptide genes might influence ligand-receptor coevolution. Four test groups of neuropeptides characterized by conserved C-terminal amino acid sequence motifs and their cognate receptors were examined in the red flour beetle (Tribolium castaneum): 1) cardioacceleratory peptide 2b (CAPA); CAPAr, 2) pyrokinin/diapause hormone (PK1/DH); PKr-A, -B, 3) pyrokinin/pheromone biosynthesis activating hormone (PK2/PBAN); PKr-C and 4) ecdysis triggering hormone (ETH); ETHr-b. Ligand-receptor specificities were established through heterologous expression of receptors in cell-based assays for 9 endogenous ligands. Based on ligand-receptor specificity analysis, we found positive pleiotropism exhibited by ETH on ETHR-b and CAPAr, whereas PK1/DH and CAPA are more highly selective for their respective authentic receptors than would be predicted by phylogenetic analysis. Disparities between evolutionary trees deduced from receptor sequences vs. functional ligand-receptor specificities lead to the conclusion that pleiotropy exhibited by peptide genes influences ligand-receptor coevolution.
Capacitance‐sharing, dual‐output, compact, switched‐capacitor DC–DC converter for low‐power biomedical implants
Authors: Safarian Z. , Hashemi H. 
Published: October 2014

A dual‐output, compact, switched‐capacitor DC–DC converter is presented for efficient voltage generation in low‐power biomedical implants. By sharing the charge transfer capacitors between multiple independent switched‐capacitor DC–DC converters, fewer capacitors are required, resulting in overall system size reduction. A proof‐of‐concept capacitance‐sharing, dual‐output DC–DC converter, converting 1.2 V – 0.4 V and 0.8 V, fabricated in a 0.13 μm CMOS technology, occupying 0.3 mm2 and achieving a peak efficiency of 97.6% is demonstrated.
Dual‐mode CMOS feed‐forward transimpedance amplifier for LADARs
Authors: Kim Seung‐Hoon , Cho Sang‐Bock , Park Sung Min 
Published: October 2014

A dual‐mode transimpedance amplifier (TIA) is realised in a 0.18 μm CMOS technology for the applications of 1 Gbit/s laser detection and ranging (LADAR) systems. The proposed dual‐mode CMOS feed‐forward TIA consists of a voltage‐mode inverter input stage with a feedback resistor, followed by a current‐mode common‐gate amplifier with a feed‐forward technique applied at the gate so as to achieve low noise, low power consumption, high gain and wide bandwidth characteristics simultaneously. The measured results demonstrate 76 dBΩ transimpedance gain, 720 MHz bandwidth for 0.5 pF photodiode capacitance, −26.3 dBm sensitivity for 10−12 bit error rate and 20.7 mW power dissipation from a single 1.8 V supply.
Use of protein cross-linking and radiolytic footprinting to elucidate PsbP and PsbQ interactions within higher plant Photosystem II
Authors: Mummadisetti Manjula P. , Frankel Laurie K. , Bellamy Henry D. , Sallans Larry , Goettert Jost S. , Brylinski Michal , Limbach Patrick A. , Bricker Terry M. 
Published: October 2014

SignificanceIn higher plant Photosystem II, the PsbP and PsbQ proteins provide critical support for oxygen evolution at physiological calcium and chloride concentrations. The locations of these components within the photosystem, however, are unclear. Our findings that (i) the N terminus of PsbP, which is unresolved in the current high-resolution structure of this subunit, forms a compact structure and associates with the C-terminal domain of the protein and (ii) PsbP and PsbQ directly interact to form a framework for understanding the organization of these subunits within the higher plant photosystem.
Selective allosteric coupling in core chemotaxis signaling complexes
Authors: Li Mingshan , Hazelbauer Gerald L. 
Published: October 2014

Significance
The notable cooperativity and signal amplification of bacterial chemotaxis are thought to arise from allosteric interactions in its multicomponent, membrane-bound signaling complexes. However, little is known about this presumed allostery. By characterizing signaling in isolated core signaling complexes, assembled using Nanodisc-inserted transmembrane chemoreceptors, we found that core complexes were not unified allosteric units. Instead, allosteric coupling among its components was selective and asymmetric. This observation was unanticipated and has significant implications for understanding the central coupling of ligand-occupied chemoreceptors to chemotaxis histidine kinases. More widely, our observations provide an example of unconventional asymmetry within an allosteric unit. In addition, we deduced allosteric coupling between protomers of the dimeric kinase, identifying a crucial link in the allosteric spread of ligand-induced kinase inhibition.
Criterion for stability of Goldstone modes and Fermi liquid behavior in a metal with broken symmetry
Authors: Watanabe Haruki , Vishwanath Ashvin 
Published: October 2014

Significance
A remarkable feature of many particle systems is that although they are described by equations respecting various symmetries, they may spontaneously organize into a state that explicitly breaks symmetries. An example is a crystal that breaks the translation symmetry of space. In such cases, a celebrated theorem predicts an excitation, the Goldstone mode. In this paper we examine whether this continues to hold inside a metal, where electrons can collide with the Goldstone excitations. Our result is a one-equation criterion that specifies whether the interactions between electrons and Goldstone modes can be ignored or whether it completely changes their character. In the latter case, unusual phases of matter such as non-Fermi liquids or superconductors may arise.
Enhanced chondrogenesis with upregulation of PKR using a novel hydrostatic pressure bioreactor
Authors: Kim Jeonghyun , Montagne Kevin , Ushida Takashi , Furukawa Katsuko 
Published: October 2014

Abstract
In this study, we developed a novel bioreactor to load hydrostatic pressure to promote chondrogenesis of prechondrogenic ATDC5 cells in as little as 3 days. Furthermore, we showed that loading hydrostatic pressure induced the upregulation of PKR, which is known to participate in mechanotransduction in various models.
SEABED: Small molEcule activity scanner weB servicE baseD
Authors: Fenollosa Carlos , Otón Marcel , Andrio Pau , Cortés Jorge , Orozco Modesto , Goñi J. Ramon 
Published: October 2014

AbstractMotivation: The SEABED web server integrates a variety of docking and QSAR techniques in a user-friendly environment. SEABED goes beyond the basic docking and QSAR web tools and implements extended functionalities like receptor preparation, library editing, flexible ensemble docking, hybrid docking/QSAR experiments or virtual screening on protein mutants. SEABED is not a monolithic workflow tool but Software as a Service platform.Availability and implementation: SEABED is a free web server available at http://www.bsc.es/SEABED. No registration is required.Contact: ramon.goni@bsc.esSupplementary information: Supplementary data are available at Bioinformatics online.
Phase I Dose-Escalation Study of Weekly Paclitaxel and Cisplatin Followed by Radical Hysterectomy in Stages IB2 and IIA2 Cervical Cancer
Authors: Chou Hung-Hsueh , Huang Huei-Jean , Lin Hao , Yang Lan-Yan , Hsueh Swei , Liu Feng-Yuan , Liou Yen-Lyin , Liou Jui-Der , Chen Min-Yu , Chao Angel , Lin Gigin , Chang Ting-Chang , Lai Chyong-Huey 
Published: October 2014

Purpose:
To define the optimal dose of paclitaxel combining cisplatin, as weekly neoadjuvant chemotherapy (NAC) for early-stage bulky squamous cell carcinoma of the uterine cervix.

Methods:
A prospective trial was conducted for International Federation of Gynecology and Obstetrics stages IB2 and IIA2 cervical squamous cell carcinoma patients with magnetic resonance imaging or positron emission tomography-defined lymph node negative. Weekly fixed-dose cisplatin (40 mg/m2) and 4-level dose escalation of paclitaxel (50, 60, 70, 80 mg/m2) for 3 courses was given and followed by radical hysterectomy and pelvic lymph node dissection (RH-PLND) 14 to 28 days later. Postoperative adjuvant therapy was tailored according to pathologic response.

Results:
No dose-limiting toxicity occurred. Twelve subjects were enrolled without reaching maximum tolerated dose, nor was any RH-PLND procedure delayed for >2 weeks. Pathologic response rate was 50% (complete in 2 and partial in 4). Paclitaxel dose level seemed unrelated to pathologic response. No subjects had grade ≥3 acute adverse events. Seven patients (58.3%) received postoperative radiotherapy or chemoradiation. Patients with human papillomavirus 16-negative tumor and aged 55 years and older had marginally higher risk (100%) of adjuvant radiotherapy or chemoradiation after NAC than those with human papillomavirus 16-positive or age less than 55 (P=0.081). With a median follow-up of 45.5 months, all 12 patients remained alive without disease.

Conclusions:
Weekly paclitaxel and cisplatin NAC for 3 courses can be tolerated with excellent short-term outcome. With the caveat of small number of patients, this study supports future phase II trials of weekly paclitaxel and cisplatin NAC for 4 to 5 cycles.
giganteaSuppressesimmutansVariegation by Interactions with Cytokinin and Gibberellin Signaling Pathways
Authors: Putarjunan Aarthi , Rodermel Steve 
Published: October 2014

AbstractThe immutans (im) variegation mutant of Arabidopsis (Arabidopsis thaliana) is an ideal model to gain insight into factors that control chloroplast biogenesis. im defines the gene for PTOX, a plastoquinol terminal oxidase that participates in the control of thylakoid redox. Here, we report that the im defect can be suppressed during the late stages of plant development by gigantea (gi2), which defines the gene for GI, a central component of the circadian clock that plays a poorly understood role in diverse plant developmental processes. imgi2 mutants are late flowering and display other well-known phenotypes associated with gi2, such as starch accumulation and resistance to oxidative stress. We show that the restoration of chloroplast biogenesis in imgi2 is caused by a development-specific derepression of cytokinin signaling that involves cross talk with signaling pathways mediated by gibberellin (GA) and SPINDLY (SPY), a GA response inhibitor. Suppression of the plastid defect in imgi2 is likely caused by a relaxation of excitation pressures in developing plastids by factors contributed by gi2, including enhanced rates of photosynthesis and increased resistance to oxidative stress. Interestingly, the suppression phenotype of imgi can be mimicked by crossing im with the starch accumulation mutant, starch excess1 (sex1), perhaps because sex1 utilizes pathways similar to gi. We conclude that our studies provide a direct genetic linkage between GI and chloroplast biogenesis, and we construct a model of interactions between signaling pathways mediated by gi, GA, SPY, cytokinins, and sex1 that are required for chloroplast biogenesis.
Linking territorial foresight and urban planning
Authors: Miguel Fernández Güell José , Redondo Leticia 
Published: November 2014

PurposeThis article aims to show the opportunity and benefits of linking territorial foresight tools to urban planning procedures. Additionally, it suggests ways to reinforce the scenario design method with more in‐depth analysis, without losing its qualitative nature and communication advantages.Design/methodology/approachThese assumptions are tested in a scenario design exercise that explores the future evolution of the sustainable development paradigm and its implications in the Spanish urban development model.FindingsMajor findings are obtained on the feasibility of a systematic approach that provides anticipatory intelligence about future disruptive events that may affect the natural environment and the socioeconomic fabric of a given territory. In addition, the study confirms that foresight offers interesting opportunities for urban planners, such as anticipating changes, fostering participation and building networks, in contrast to its perception as a mere story‐telling technique that generates oversimplified visions without the backing of rigorous analysis.Research limitations/implicationsIn order to boost the perception of scenario design as an added value instrument for urban planners, three sets of implications – functional, parametric and spatial – are displayed to provide substantial information for policy makers.Originality/valueThe value of the present work lies in the synergy that can be generated between territorial foresight and urban planning, offering a great opportunity for policy makers to use futurists' output as input for urban planners' work.