bluuebunny/crossref_metadata_2025_split huggingface dataset:
Outcomes with FOLFIRINOX for borderline resectable and locally unresectable pancreatic cancer
Authors: Boone Brian A. , Steve Jennifer , Krasinskas Alyssa M. , Zureikat Amer H. , Lembersky Barry C. , Gibson Michael K. , Stoller Ronald G. , Zeh Herbert J. , Bahary Nathan 
Published: August 2013

AbstractBackgroundTrials examining FOLFIRINOX in metastatic pancreatic cancer demonstrate higher response rates compared to gemcitabine‐based regimens. There is currently limited experience with neoadjuvant FOLFIRINOX in pancreatic cancer.MethodsRetrospective review of outcomes of patients with borderline resectable or locally unresectable pancreatic cancer who were recommended to undergo neoadjuvant treatment with FOLFIRINOX.ResultsFOLFIRINOX was recommended for 25 patients with pancreatic cancer, 13 (52%) unresectable and 12 (48%) borderline resectable. Four patients (16%) refused treatment or were lost to follow‐up. Twenty‐one patients (84%) were treated with a median of 4.7 cycles. Six patients (29%) required dose reductions secondary to toxicity. Two patients (9%) were unable to tolerate treatment and three patients (14%) had disease progression on treatment. Seven patients (33%) underwent surgical resection following treatment with FOLFIRINOX alone, 2 (10%) of which were initially unresectable. Two patients underwent resection following FOLFIRINOX + stereotactic body radiation therapy (SBRT). The R0 resection rate for patients treated with FOLFIRINOX ± SBRT was 33% (55% borderline resectable, 10% unresectable). A total of five patients (24%) demonstrated a significant pathologic response.ConclusionsFOLFIRINOX is a biologically active regimen in borderline resectable and locally unresectable pancreatic cancer with encouraging R0 resection and pathologic response rates. J. Surg. Oncol. 2013 108:236–241. © 2013 Wiley Periodicals, Inc.
A Hierarchical and Comparative Kinetic Modeling Study of C1 − C2 Hydrocarbon and Oxygenated Fuels
Authors: Metcalfe Wayne K. , Burke Sinéad M. , Ahmed Syed S. , Curran Henry J. 
Published: August 2013

ABSTRACTA detailed chemical kinetic mechanism has been developed to describe the oxidation of small hydrocarbon and oxygenated hydrocarbon species. The reactivity of these small fuels and intermediates is of critical importance in understanding and accurately describing the combustion characteristics, such as ignition delay time, flame speed, and emissions of practical fuels. The chosen rate expressions have been assembled through critical evaluation of the literature, with minimum optimization performed. The mechanism has been validated over a wide range of initial conditions and experimental devices, including flow reactor, shock tube, jet‐stirred reactor, and flame studies. The current mechanism contains accurate kinetic descriptions for saturated and unsaturated hydrocarbons, namely methane, ethane, ethylene, and acetylene, and oxygenated species; formaldehyde, methanol, acetaldehyde, and ethanol.
Preclinical high‐dose acetaminophen with N‐acetylcysteine rescue enhances the efficacy of cisplatin chemotherapy in atypical teratoid rhabdoid tumors
Authors: Neuwelt Alexander J. , Nguyen Tam , Wu Y. Jeffrey , Donson Andrew M. , Vibhakar Rajeev , Venkatamaran Sujatha , Amani Vladimir , Neuwelt Edward A. , Rapkin Louis B. , Foreman Nicholas K. 
Published: August 2013

AbstractBackgroundAtypical teratoid rhabdoid tumors (AT‐RT) are pediatric tumors of the central nervous system with limited treatment options and poor survival rate. We investigated whether enhancing chemotherapy toxicity by depleting intracellular glutathione (GSH; a key molecule in cisplatin resistance) with high dose acetaminophen (AAP), may improve therapeutic efficacy in AT‐RT in vitro.ProcedureBT16 (cisplatin‐resistant) and BT12 (cisplatin‐sensitive) AT‐RT cell lines were treated with combinations of AAP, cisplatin, and the anti‐oxidant N‐acetylcysteine (NAC). Cell viability, GSH and peroxide concentrations, mitochondrial damage, and apoptosis were evaluated in vitro.ResultsAAP enhanced cisplatin cytotoxicity in cisplatin‐resistant BT16 cells but not cisplatin‐sensitive BT12 cells. Baseline GSH levels were elevated in BT16 cells compared to BT12 cells, and AAP decreased GSH to a greater magnitude in BT16 cells than BT12 cells. Unlike BT12 cells, BT16 cells did not have elevated peroxide levels upon treatment with cisplatin alone, but did have elevated levels when treated with AAP + cisplatin. Both cell lines had markedly increased mitochondrial injury when treated with AAP + cisplatin relative to either drug treatment alone. The enhanced toxic effects were partially reversed with concurrent administration of NAC.ConclusionsOur results suggest that AAP could be used as a chemo‐enhancement agent to potentiate cisplatin chemotherapeutic efficacy particularly in cisplatin‐resistant AT‐RT tumors with high GSH levels in clinical settings. Pediatr Blood Cancer 2014;61:120–127. © 2013 Wiley Periodicals, Inc.
Justification for Chest Physiotherapy during Ultra‐Protective Lung Ventilation and Extra‐Corporeal Membrane Oxygenation: A Case Study
Authors: Cork G. , Barrett N. , Ntoumenopoulos G. 
Published: August 2013

AbstractBackground and purposeThis case report describes the chest physiotherapy (CPT) intervention provided to a 32‐year old man with severe respiratory failure undergoing extra‐corporeal membrane oxygenation (ECMO) support and ultra‐protective ventilatory strategy. Low tidal volume ventilation when used in patients with extremely low dynamic respiratory compliance may predispose the patient to secretion retention, and the role of CPT in this setting is unclear.MethodThe method used is a single subject case report. Written consent obtained from patient's representative.SummarySecretion clearance in this patient was initially limited to suctioning; however, after developing major airway occlusion secondary to impacted secretions, he received intensive CPT consisting of positioning, ventilator hyperinflation, expiratory chest wall shaking and suctioning. After 13 days of two to three times daily CPT, the patient weaned from ECMO support.DiscussionRegular CPT may have facilitated secretion clearance and lung recovery in this patient. Future research should investigate the optimal CPT techniques for patients with sub‐dead space tidal ventilation and extremely low dynamic respiratory compliance during ECMO with ultra‐protective ventilatory strategy (UPVS). Copyright © 2013 John Wiley & Sons, Ltd.
Akt Suppression of TGFβ Signaling Contributes to the Maintenance of Vascular Identity in Embryonic Stem Cell-Derived Endothelial Cells
Authors: Israely Edo , Ginsberg Michael , Nolan Daniel , Ding Bi-Sen , James Daylon , Elemento Olivier , Rafii Shahin , Rabbany Sina Y. 
Published: August 2013

Abstract
The ability to generate and maintain stable in vitro cultures of mouse endothelial cells (ECs) has great potential for genetic dissection of the numerous pathologies involving vascular dysfunction as well as therapeutic applications. However, previous efforts at achieving sustained cultures of primary stable murine vascular cells have fallen short, and the cellular requirements for EC maintenance in vitro remain undefined. In this study, we have generated vascular ECs from mouse embryonic stem (ES) cells and show that active Akt is essential to their survival and propagation as homogeneous monolayers in vitro. These cells harbor the phenotypical, biochemical, and functional characteristics of ECs and expand throughout long-term cultures, while maintaining their angiogenic capacity. Moreover, Akt-transduced embryonic ECs form functional perfused vessels in vivo that anastomose with host blood vessels. We provide evidence for a novel function of Akt in stabilizing EC identity, whereby the activated form of the protein protects mouse ES cell-derived ECs from TGFβ-mediated transdifferentiation by downregulating SMAD3. These findings identify a role for Akt in regulating the developmental potential of ES cell-derived ECs and demonstrate that active Akt maintains endothelial identity in embryonic ECs by interfering with active TGFβ-mediated processes that would ordinarily usher these cells to alternate fates. Stem Cells 2014;32:177–190
Developing Multiple Literacies in Academic English Through Service‐Learning and Community Engagement
Authors: Askildson Lance R. , Kelly Annie Cahill , Mick Connie Snyder 
Published: August 2013

Research on service‐learning offers compelling evidence of the advances student learners make in moral development, orientation to prosocial behavior, and curricular content retention. But who are those student learners? Most studies focus on native, dominant‐culture, dominant‐language students serving marginalized populations. Studies of the United States, for example, primarily focus on English‐speaking U.S. citizens serving either linguistically and culturally similar populations marked by economic, educational, or health vulnerabilities, or linguistically and culturally different populations to facilitate the acquisition of another language or cultural tradition, such as tutoring at a Latino community center in order to learn Spanish. Much less research has focused on English language learners as agents of service in the United States, volunteering at U.S. social service agencies in order to increase their own acquisition of the English language and U.S. culture. This study addresses that gap in the research by analyzing results of a language immersion program that aimed to develop multiple literacies in academic English through service‐learning and community engagement. The study documents significant gains in intercultural awareness and advanced language acquisition over 8 weeks of service‐learning, recommending service‐learning as an exceptional pedagogical mechanism for domestic and international programs in intercultural development and second language acquisition.
Impacts and management of invasive cool‐season grasses in the Northern Great Plains: Challenges and opportunities for wildlife
Authors: Ellis‐Felege Susan N. , Dixon Cami S. , Wilson Scott D. 
Published: August 2013

ABSTRACTGrasslands of the Northern Great Plains of North America are in the midst of extensive human‐driven loss and redistribution of important species. Invasive plants contribute to degradation of this ecosystem and present monumental challenges for natural resource managers. Widespread decreases in populations of grassland‐dependent wildlife, particularly birds, have been documented, but relatively little research has been focused on direct responses of wildlife to invading plants relative to native vegetation. Smooth brome (Bromus inermis) and Kentucky bluegrass (Poa pratensis) are 2 invasive cool‐season grass species found across much of the Northern Great Plains that continue to expand despite management actions intended to reduce them. With eradication unlikely, creativity, cooperation, and science‐based management (e.g., Adaptive Management) are paramount to protect and restore the integrity of grassland habitats across the Northern Great Plains. Published 2013. This article is a U.S. Government work and is in the public domain in the USA.
Luffa cylindrica and phytosterols bioconversion: from shake flask to jar bioreactor
Authors: Bou Saab Hamid , Fouchard Samuel , Boulanger Anna , Llopiz Pierre , Neunlist Serge 
Published: August 2013

Abstract
Bioconversion of lipophilic compounds poorly soluble in water, such as sterols, required the use of chemicals and solubilizing agents. On the other hand, it was shown that immobilization of Mycobacterium species on the dried fruit of Luffa cylindrica (DFLC) allows a close interaction between immobilized cells and cholesterol particles and increases by then the product’s yield. In this work, the use of DFLC in a 5-l jar bioreactor with phytosterols mixture (1 g/l) as substrate was assessed without addition of any chemicals or solubilizing agents. DFLC increased by a factor of four the volumetric productivity of androstenones (0.08 g/l day). Products were accumulated in the aqueous medium while substrates remained on the fibers of DFLC. This observation lets envisage a green semi-continuous process of androstenone production. DFLC has no influence on cell growth, and is moreover natural, inexpensive, non-toxic, and mechanically strong.
Attitude of Medical School Students in China Towards Genetic Testing and Counseling Issues in FXS
Authors: Li Jia , Huang Wen , Luo Shiyu , Lin Yunting , Duan Ranhui 
Published: August 2013

AbstractFragile X syndrome (FXS) is the most common form of inherited intellectual disability. However, genetic testing protocols and genetic counseling guidelines for FXS are not yet established in mainland China. In the present study, we conducted a comprehensive analysis using a self‐administered questionnaire among students at the Xiangya medical school to investigate their attitude towards genetic testing and counseling issues of FXS. We have gained a general understanding of the attitudes of medical students towards these FXS issues in China. This information is of immense importance to develop appropriate genetic tests and to train counselors for FXS. As the medical school students surveyed are prospective physicians who will be a part of the Chinese health system, our survey was focused on the basic knowledge of FXS, population‐based FXS screening, confidentiality and reproductive options for mutation carriers. The study demonstrated that only less than one third of the participants had heard about FXS. 94.6 % of participants were in favor of FXS screening for women in their reproductive age who had a genetic history of FXS. Furthermore, only half of the participants would inform their families about their genetic status in case of positive test results, and more than half of the participants supported natural conception and prenatal diagnosis for FXS mutation carriers. Additional findings and research implications are also discussed. This survey targeting potential doctors provides important information for the development of FXS genetic test and counselor training for the Chinese health system.
Research on the Influence of the Type of Surfactant and Concentrator in Aqueous Dispersion of Pigments
Authors: Makarewicz Edwin , Michalik Agnieszka 
Published: August 2013

AbstractThis work reports tests performed to evaluate the stability of aqueous dispersions of inorganic oxide pigments with different specific surface areas, with the use of anionic and non‐ionic surfactants and concentrators. Color mixtures of oxide compounds of blue, green, olive and brown with the unit cell spinel structure were used as pigments. The sodium salt of sulfosuccinic acid monoester, oxyethylenated nonylphenol and ethoxylated derivatives of lauryl alcohol, fatty alcohol and fatty amine were used as surfactants. The concentrators used were: poly(vinyl alcohol), the sodium salt of carboxymethyl cellulose as well as a water‐based polyurethane oligomer. The highest dispersion efficiency was found for dispersed systems in which surfactant and concentrator were incorporated in the formula. The one containing the sodium salt of carboxymethyl cellulose or polyurethane oligomer with ethoxylated saturated fatty alcohol or fatty amine was found to be the most efficient. It was discovered that a higher dispersion efficiency corresponds to pigments with larger specific surface. The efficiency is also found to improve when the concentrator is an acrylic polymer or copolymer made up of two acrylic species. In this case, the concentrator interaction with the surfactant is more effective if the value of its boundary viscosity number is higher. This observation confirms the existence of interactions between macro‐chains of the concentrator and surfactant molecules forming micelles with the pigment particles.
Electrostatic Effect on Synergism of Wormlike Micelles and Hydrophobically Modified Polyacrylic Acid
Authors: Mei Yongjun , Han Yixiu , Wang Hang , Xie Lin , Zhou Hong 
Published: August 2013

AbstractThe electrostatic effects on the synergism between wormlike micelles and hydrophobically modified polyacrylic acid (HMPA) have been investigated by rheological measurements and dissipative particle dynamics molecular simulation (DPD). Both cationic surfactants, cetyltrimethylammonium bromide (CTAB), and anionic surfactant, sodium oleate (NaOA), were employed to construct wormlike micelles, and the influences of both simple salts, NaBr or NaAc, and hydrophobic salts, sodium benzoate (NaBen) and benzyltrimethyl ammonium bromide (BTAB), were discussed. The synergistic effects vary with the headgroup charge and the counterions property of surfactants. For the NaOA system, the obvious viscosity maximum was observed only at low NaAc content, while a monotonous viscosity increase appeared at a high content of BTAB. However, the optimal synergism can be only observed in the presence of concentrated NaBen in CTAB system. DPD molecular simulation provides a support and favorable illustration for the synergism mechanism. It suggests that not only the hydrophobic interaction but also the electrostatic interaction has an important impact on the synergism between ionic wormlike micelles and HMPA.
Moderate Compared to Low Dietary Intake of trans‐Fatty Acids Impairs Strength of Old and Aerobic Capacity of Young SAMP8 Mice in Both Sexes
Authors: Liou Jesse , Tuazon Marc A. , Burdzy Alex , Henderson Gregory C. 
Published: August 2013

AbstractThe senescence accelerated SAMP8 mouse is a model for sarcopenia and provides an opportunity to study the effects of lifelong dietary composition on the loss of physical function with age. We studied the effects of trans‐fatty acids (2 % of total energy, TFA diet) on the loss of strength and aerobic exercise capacity (VO2peak) with age. SAMP8 mice were studied at two ages (young, 25 weeks; old, 60 weeks) and on two diets (control vs TFA). Body composition, grip strength, VO2peak, blood metabolites, and biochemical parameters were assessed. Body weight, fat mass, and body fat percentage all increased with age (p < 0.05) but were not significantly impacted by diet. There was a significant age‐related decline in total grip strength as well as that normalized to fat‐free mass (FFM) (p < 0.05) with a further decrease at old age in these metrics of strength on the TFA diet vs control diet (p < 0.05). Total VO2peak exhibited no change with age or diet, but when normalized to FFM, VO2peak exhibited age and TFA‐related declines (p < 0.05). Intramuscular triacylglycerol (p < 0.05) and collagen content (p < 0.05) significantly increased with age, while blood triacylglycerol was increased by the TFA diet (p < 0.05). These data further characterize the SAMP8 mouse as a model for sarcopenia and indicate that dietary fatty acid composition can impact the degree of this age‐related loss of physical function.
Experimental Solid–Liquid Phase Equilibria of a Methyl Ester/Amide/Nitrile Ternary System by DSC
Authors: Mekki‐Berrada A. , Bennici S. , Dubois J.‐L. , Auroux A. 
Published: August 2013

AbstractBinary and ternary mixtures of lauric methyl ester, amide and nitrile were investigated by differential scanning calorimetry, in order to determine the solid–liquid phase equilibria of this model for saturated organic systems. Eutectic mixtures were observed and followed in the ternary system, while solid–solid transitions and immiscibility phenomena were also characterized. This system is also of industrial interest for processes in the frame of biomass valorization.
Package size and perceived quality: The intervening role of unit price perceptions
Authors: Yan Dengfeng , Sengupta Jaideep , Wyer Robert S. 
Published: August 2013

AbstractThis research examines how package size can influence quality judgments for packaged goods, and also identifies a price‐based mechanism for the observed size–quality relationship. Results from several studies show that a product in a smaller package is rated more favorably than the equivalent product in a larger package. Further, this effect is due to the smaller package being associated with a higher unit price (despite having a lower overall price), which suggests that unit price information is more diagnostic than overall price information when forming judgments of product quality. We also find a theoretically‐derived reversal of this effect under conditions in which the greater diagnosticity of unit price is overwhelmed by its lower ease of use. Namely, when overall price is the only explicitly‐provided price cue and consumers are too distracted to estimate unit price, a larger package is now rated as being better. Finally, two concluding studies examine the downstream consequences of changes in package size, building off our basic conceptualization to document effects on product choice as well as consumption experience.
Alteration in the global and regional myocardial strain patterns in patients with inferior ST‐elevation myocardial infarction prior to and after percutaneous coronary intervention
Authors: Song Chen‐Fang , Zhou Qing , Guo Rui‐Qiang 
Published: August 2013

AbstractThis study was designed to investigate the alteration on regional and global strains of left and right ventricle (LV, RV) in patients with inferior wall ST‐elevation myocardial infarction (MI). Patients were examined prior to and 7 days after percutaneous coronary intervention (PCI) using speckle‐tracking techniques. Fifty‐nine patients (36 males and 23 females) and 60 healthy controls (40 males and 20 females) were enrolled in this study. LV strains were measured from three deformations including radial, longitudinal, and circumferential. RV strains were measured only from the longitudinal. Three types of LV global strains were significantly lower in patients than in controls, and LV global longitudinal and circumferential strains were moderately improved by PCI. The LV regional strains reduced significantly in most of the segments (87%) after inferior wall MI and over half of them (60%) were improved by PCI. The RV global longitudinal strains were significantly lower in patients than in controls, and they were moderately improved by PCI. In conclusion, the regional and global strains of LV and RV were reduced in patients with inferior wall MI, and PCI most markedly improved the global strains and regional strains of the infarct and adjacent myocardium in the apical and middle levels.
Milnor descent for cohesive dg-categories
Authors: Ben-Bassat Oren , Block Jonathan 
Published: August 2013

AbstractWe show that the functor from curved differential graded algebras to differential graded categories, defined by the second author, sends Cartesian diagrams to homotopy Cartesian diagrams, under certain reasonable hypotheses. This is an extension to the arena of dg-categories of a construction of projective modules due to Milnor. As an example, we show that the functor satisfies descent for certain partitions of a complex manifold.