bluuebunny/crossref_metadata_2025_split huggingface dataset:
Doege-Potter syndrome due to a solitary fibrous tumor of the pleura: a case report
Authors: Estrada-Maya Juan , Montejo Juan Sebastián , Báez López Katerin Dayana , Garzón Juan Carlos 
Published: August 2024

Abstract
Background
Doege-Potter syndrome is a rare paraneoplastic phenomenon associated with solitary fibrous tumors of the pleura (SFTPs). It is characterized by the presence of severe, sustained, and treatment-refractory hypoglycemia. Hypoglycaemia, which may be the sole symptom at disease onset, is mediated by the secretion of high-molecular-weight insulin-like growth factor (IGF-2). Most tumors exhibit benign behavior, with a 100% survival rate at 5 years. However, 10% of these tumors may display aggressive behavior with local or metastatic recurrence. We present a clinical case of a patient with a benign solitary fibrous tumor of the pleura who presented with symptomatic hypoglycemia and required pulmonary and pleural surgical resection to control the paraneoplastic phenomenon.

Case presentation
A Hispanic 46-year-old man presented with a 15-day history of transient alterations in consciousness worsened by fasting. The relevant medical history included obstructive sleep apnea treated with continuous positive air pressure (CPAP) and previous smoking. In-hospital studies revealed noninsulinemic hypoglycemia and a benign SFTP. Complete surgical resection was performed while the patient received dextrose fluids and corticosteroids perioperatively for hypoglycemia. Subsequently, the hypoglycemia resolved, and the patient was followed-up without disease recurrence.

Conclusion
Doege-Potter syndrome is challenging to recognize. However, effective treatment can be achieved with a high survival rate. Raising awareness among healthcare professionals about the recognition of this paraneoplasic syndrome patients will improve diagnostic suspicion, biochemical confirmation, the development of diagnostic and therapeutic guidelines, and the creation of predictive indices for aggressive presentations requiring closer monitoring.
An approach based on P-wave velocity for grouting effectiveness evaluation in earthen sites
Authors: Li Weihao , Zhang Jingke , Wang Nan , Zhang Yichen , Qi Bojia , Chen Jiayi , Yin Xingduo 
Published: August 2024

Abstract
Grouting technology is the primary method for repairing cracks in earthen sites. However, there has been a long-standing lack of effective methods for evaluating grouting effectiveness. This paper proposes a field evaluation method based on P-wave velocity. This method explicitly discusses two scenarios where the P-wave velocity of the grout is either higher or lower than that of the soil, using the depth ℎ of the “hypothetical crack” as the evaluation indicator. The experimental results indicate that specimens with 20% and 40% defects show increases in ℎ values of 0.0113 m and 0.0166 m, respectively. Laboratory tests have demonstrated that this method can accurately evaluate grouting effectiveness and is not affected by the P-wave velocity of the soil. The application of this evaluation method to three typical earthen sites resulted in more reliable and easily quantifiable evaluation outcomes. By considering the width of grout, the method provides a more intuitive comparison of reparation effectiveness. The study demonstrates the feasibility of the proposed method, thereby facilitating effective crack reparation in earthen sites.
Uncovering waterlogging-responsive genes in cucumber through machine learning and differential gene correlation analysis
Authors: Zinati Zahra , Nazari Leyla , Niazi Ali 
Published: August 2024

AbstractAs climate change intensifies, the frequency and severity of waterlogging are expected to increase, necessitating a deeper understanding of the cucumber response to this stress. In this study, three public RNA-seq datasets (PRJNA799460, PRJNA844418, and PRJNA678740) comprising 36 samples were analyzed. Various feature selection algorithms including Uncertainty, Relief, SVM (Support Vector Machine), Correlation, and logistic least absolute shrinkage, and selection operator (LASSO) were performed to identify the most significant genes related to the waterlogging stress response. These feature selection techniques, which have different characteristics, were used to reduce the complexity of the data and thereby identify the most significant genes related to the waterlogging stress response. Uncertainty, Relief, SVM, Correlation, and LASSO identified 4, 4, 10, 21, and 13 genes, respectively. Differential gene correlation analysis (DGCA) focusing on the 36 selected genes identified changes in correlation patterns between the selected genes under waterlogged versus control conditions, providing deeper insights into the regulatory networks and interactions among the selected genes. DGCA revealed significant changes in the correlation of 13 genes between control and waterlogging conditions. Finally, we validated 13 genes using the Random Forest (RF) classifier, which achieved 100% accuracy and a 1.0 Area Under the Curve (AUC) score. The SHapley Additive exPlanations (SHAP) values clearly showed the significant impact of LOC101209599, LOC101217277, and LOC101216320 on the model’s predictive power. In addition, we employed the Boruta as a wrapper feature selection method to further validate our gene selection strategy. Eight of the 13 genes were common across the four feature weighting algorithms, LASSO, DGCA, and Boruta, underscoring the robustness and reliability of our gene selection strategy. Notably, the genes LOC101209599, LOC101217277, and LOC101216320 were among genes identified by multiple feature selection methods from different categories (filtering, wrapper, and embedded). Pathways associated with these specific genes play a pivotal role in regulating stress tolerance, root development, nutrient absorption, sugar metabolism, gene expression, protein degradation, and calcium signaling. These intricate regulatory mechanisms are crucial for cucumbers to adapt effectively to waterlogging conditions. These findings provide valuable insights for uncovering targets in breeding new cucumber varieties with enhanced stress tolerance.
Conveyor CVD to high-quality and productivity of large-area graphene and its potentiality
Authors: Lee Dong Yun , Nam Jungtae , Lee Gil Yong , Lee Imbok , Jang A-Rang , Kim Keun Soo 
Published: August 2024

AbstractThe mass production of high-quality graphene is required for industrial application as a future electronic material. However, the chemical vapor deposition (CVD) systems previously studied for graphene production face bottlenecks in terms of quality, speed, and reproducibility. Herein, we report a novel conveyor CVD system that enables rapid graphene synthesis using liquid precursors. Pristine and nitrogen-doped graphene samples of a size comparable to a smartphone (15 cm × 5 cm) are successfully synthesized at temperatures of 900, 950, and 1000 °C using butane and pyridine, respectively. Raman spectroscopy allows optimization of the rapid-synthesis conditions to achieve uniformity and high quality. By conducting compositional analysis via X-ray photoelectron spectroscopy as well as electrical characterization, it is confirmed that graphene synthesis and nitrogen doping degree can be adjusted by varying the synthesis conditions. Testing the corresponding graphene samples as gas-sensor channels for NH3 and NO2 and evaluating their response characteristics show that the gas sensors exhibit polar characteristics in terms of gas adsorption and desorption depending on the type of gas, with contrasting characteristics depending on the presence or absence of nitrogen doping; nitrogen-doped graphene exhibits superior gas-sensing sensitivity and response speed compared with pristine graphene.
Enhancing marl soil stability: nanosilica’s role in mitigating ettringite formation
Authors: Amiri Mohammad , Asakereh Adel , Farokhdel Aminhosein , Atash poosh Hosein 
Published: August 2024

AbstractMarl soil is highly prone to erosion when exposed to water flow, posing a potential threat to structural stability. The common practice of stabilizing soil involves the addition of cement and lime. However, persistent reports of severe ruptures in many stabilized soils, even after extended periods, have raised concerns. In stabilized marls, unexpected ruptures primarily result from the formation of ettringite, which gradually damages the soil structure. This article aims to assess the impact of nanosilica on the formation of ettringite and the nanostructure of calcium silicate hydrate (C-S-H) during the marl soil stabilization process with lime. To achieve this, marl soil was stabilized with varying percentages of lime and nanosilica. X-ray diffraction (XRD) patterns and scanning electron microscopy (SEM) images were collected to observe changes in mineralogy and microstructural properties. Various geotechnical parameters, including granularity, Atterberg limits, compressive strength, and pH, were measured. The results indicate that the uniform distribution of nanosilica in marl-lime soils enhances pozzolanic activities, calcium aluminate hydrate growth (C-A-H), and the nanostructure of calcium silicate hydrate (C-S-H). According to XRD and SEM experiments, the presence of nanosilica reduces the formation of ettringite. Moreover, the compressive strength of modified samples exhibited an upward trend. In the experimental sample manipulated with 1% nanosilica combined with 6% lime, the compressive strength increased by 1.84 MPa during the initial 7 days, representing an approximately 18-fold improvement compared to the control sample.
Barriers to and enablers of the use of the Otology Questionnaire Amsterdam in clinical practice—a qualitative post-implementation study
Authors: Kraak J.T. , Verhoef K. , Kramer S.E. , Merkus P. 
Published: August 2024

Abstract
Background
The Otology Questionnaire Amsterdam (OQUA) is developed to evaluate multiple ear complaints and their impact on patients’ daily lives. The current clinical use of this questionnaire is below the potential utilization.

Aim
To identify the barriers and enablers of using the OQUA as perceived by ENT surgeons and patients and provide recommendations for an implementation strategy.

Methods
Prospective and qualitative analysis was performed using focus groups and interviews with ENT professionals (n = 15) and patients (n = 25) with ear complaints of one tertiary referral hospital and two regional hospitals. Barriers and enablers were identified and classified by using the Capability-Opportunity-Motivation-Behavior model and the Theoretical Domains Framework. Suggestions for an implementation strategy will be made accordingly.

Results
ENT professionals’ barriers included lack of knowledge and skills to use the OQUA, inadequate technological support and perceived time constraints during consultation, uncertainty about the clinical relevance and lack of feedback on the outcomes of the OQUA. Enablers included beneficial consequences of the OQUA for the professional, organization and science. Patients’ barriers included lack of knowledge about the objective and usefulness of the OQUA, perceived burden, difficulties in completing the questionnaire and insufficient feedback during consultation. Patient enablers included beliefs about beneficial consequences of the OQUA for the patient, health care and society. Suggested interventions involved education, training, environmental restructuring and incentivisation.

Conclusion
Based on the findings, we propose an implementation strategy should focus on education and training about the objective, outcomes and relevance of the OQUA, environmental restructuring regarding the optimal use of the OQUA, and incentivisation with feedback on the valuable outcomes of the OQUA for the patient, professional and healthcare. Future research is needed to determine the feasibility of the implementation strategy.
Reproducibility of a single-volume dynamic CT myocardial blood flow measurement technique: validation in a swine model
Authors: Hadjiabdolhamid Negin , Zhao Yixiao , Hubbard Logan , Molloi Sabee 
Published: August 2024

Abstract
Background
We prospectively assessed the reproducibility of a novel low-dose single-volume dynamic computed tomography (CT) myocardial blood flow measurement technique.

Methods
Thirty-four pairs of measurements were made under rest and stress conditions in 13 swine (54.3 ± 12.3 kg). One or two acquisition pairs were acquired in each animal with a 10-min delay between each pair. Contrast (370 mgI/mL; 0.5 mL/kg) and a diluted contrast/saline chaser (0.5 mL/kg; 30:70 contrast/saline) were injected peripherally at 5 mL/s, followed by bolus tracking and acquisition of a single volume scan (100 kVp; 200 mA) with a 320-slice CT scanner. Bolus tracking and single volume scan data were used to derive perfusion in mL/min/g using a first-pass analysis model; the coronary perfusion territories of the left anterior descending (LAD), left circumflex (LCx), and right coronary artery (RCA) were automatically assigned using a previously validated minimum-cost path technique. The reproducibility of CT myocardial perfusion measurement within the LAD, LCx, RCA, and the whole myocardium was assessed via regression analysis. The average CT dose index (CTDI) of perfusion measurement was recorded.

Results
The repeated first (Pmyo1) and second (Pmyo2) single-volume CT perfusion measurements were related by Pmyo2 = 1.01Pmyo1 − 0.03(ρ = 0.96; RMSE = 0.08 mL/min/g; RMSE = 0.07 mL/min/g) for the whole myocardium, and by Preg2 = 0.86Preg1 + 0.13(ρ = 0.87; RMSE = 0.31 mL/min/g; RMSE = 0.29 mL/min/g) for the LAD, LCx, and RCA perfusion territories. The average CTDI of the single-volume CT perfusion measurement was 10.5 mGy.

Conclusion
The single-volume CT blood flow measurement technique provides reproducible low-dose myocardial perfusion measurement using only bolus tracking data and a single whole-heart volume scan.

Relevance statement
The single-volume CT blood flow measurement technique is a noninvasive tool that reproducibly measures myocardial perfusion and provides coronary CT angiograms, allowing for simultaneous anatomic-physiologic assessment of myocardial ischemia.

Key Points

A low-dose single-volume dynamic CT myocardial blood flow measurement technique is reproducible.

Motion misregistration artifacts are eliminated using a single-volume CT perfusion technique.

This technique enables combined anatomic-physiologic assessment of coronary artery disease.

Graphical Abstract
Predictive biomarkers in thyroid cancer in the current molecular-morphology paradigm
Authors: Carneiro Humberto Carvalho , de Andrade Natal Rodrigo , Farias Evelin Cavalcante , Bastos Aline Almeida , Guastapaglia Leila , Bezerra Alanna Mara Pinheiro Sobreira , de Oliveira Hoff Ana Amélia Fialho 
Published: August 2024

AbstractThyroid cancer is one of the most common types of cancer worldwide. It is a spectrum of different diseases, ranging from very indolent to lethal tumors. Differentiated Thyroid Carcinoma (DTC), the most common thyroid malignancy, has often an excellent prognosis, but some patients develop metastatic Radioiodine-Refractory disease (RAIR) that cannot be controlled locally. In this setting, and for patients with metastatic Medullary Thyroid Carcinoma (MTC) and Anaplastic Thyroid Carcinoma (ATC), systemic treatment with non-selective Multikinase Inhibitors (MKIs) is often employed to improve survival rates and quality of life. The molecular characterization of thyroid cancer showed that the main drivers of thyroid carcinogenesis not only correlate with morphological and clinical features but can be targeted by some modern and highly selective Kinase Inhibitors: vemurafenib and dabrafenib for carcinomas with BRAF V600E mutation, including Papillary Thyroid Carcinoma (PTC) and its subtypes; dabrafenib in association with the MEK1/2 inhibitor trametinib for BRAF V600E-mutant ATC; larotrectinib and entrectinib for thyroid carcinomas with NTRK fusions and selpercatinib and pralsetinib for MTC with RET point mutations and DTC with RET-fusions. Apart of those markers, Microsatellite Instability status (MSI), Tumor Mutation Burden (TMB) and PD1/PD-L1 assessment have been explored in thyroid tumors, although immunotherapy for ATC has shown only modest results. Herein, we present a comprehensive review of the most relevant molecular markers with predictive value in thyroid pathology.
Anatomic locations of ureterovascular fistulae: a review of 532 patients in the literature and a new series of 8 patients
Authors: Shamseldin Mohammed , Heers Hendrik , Steiner Thomas , Puls Ralf 
Published: August 2024

Abstract
Introduction
Ureterovascular fistula (UVF) is a rare but potentially life-threatening condition. Since its primary description by Moschkowitz in 1908, many case reports, studies and reviews have been written about this condition with the suggestive symptoms and risk factors repeatedly discussed. This study will be focusing on the different locations of 532 out of 605 fistulae published from 1908 up to 2022 besides eight new patients of our own.

Material and methods
A systematic review of the literature started using PubMed database searching for “ureteroarterial fistula”, “arteriovascular fistula” and “uretero vascular fistula” was performed yielding 122, 62 and 188 results respectively. Those studies and the cited literature in each study were examined to include studies, which did not appear in the primary search. A total of 605 patients in 315 publications were gathered. Only studies mentioning new patients, a clear indication of the location of the UVF, the presence/absence of urinary diversion (UD) as well as the type of UD if present were included. Ten duplicates as well as studies lacking information regarding the UVF and/or the UD (seven publications with 63 patients) were excluded, with 298 publications including 532 external patients remaining. Eight internal cases were included with a total of 540 cases.

Results
From the 540 included cases, 384 patients (71.1%) had no UD compared to 156 patients (28.9%) with UD. Due to the anatomical ureteral course, the common iliac artery (CIA) was the most common vascular component of UVF, irrespective of the presence or absence of UD. Any dispute to whether the crossing point is the common or the external iliac artery (EIA) was settled for the CIA. Further common vascular components besides CIA include the aorta, EIA, internal iliac artery (IIA) including its branches and vascular bypasses including the anastomosis sites. Other unusual arterial localizations were stated under the “others” category.

Conclusion
Identifying the location of the bleeding artery in UVF is critical and represents the most important step for successful management. We present the largest summary of described locations up to date including our own.

Graphical Abstract
Principles of clinical genetics for rheumatologists: clinical indications and interpretation of broad-based genetic testing
Authors: do Nascimento Renan Rodrigues Neves Ribeiro , Quaio Caio Robledo D’Angioli Costa , Chung Christine Hsiaoyun , de Moraes Vasconcelos Dewton , Sztajnbok Flavio Roberto , Rosa Neto Nilton Salles , Perazzio Sandro Félix 
Published: August 2024

AbstractAdvances in DNA sequencing technologies, especially next-generation sequencing (NGS), which is the basis for whole-exome sequencing (WES) and whole-genome sequencing (WGS), have profoundly transformed immune-mediated rheumatic disease diagnosis. Recently, substantial cost reductions have facilitated access to these diagnostic tools, expanded the capacity of molecular diagnostics and enabled the pursuit of precision medicine in rheumatology. Understanding the fundamental principles of genetics and diversity in genetic variant classification is a crucial milestone in rheumatology. However, despite the growing availability of DNA sequencing platforms, a significant number of autoinflammatory diseases (AIDs), neuromuscular disorders, hereditary collagen diseases, and monogenic bone diseases remain unsolved, and variants of uncertain significance (VUS) pose a formidable challenge to addressing these unmet needs in the coming decades. This article aims to provide an overview of the clinical indications and interpretation of comprehensive genetic testing in the medical field, addressing the related complexities and implications.
Prognostic values of right ventricular echocardiography functional parameters for mortality prediction in precapillary pulmonary hypertension: a systematic review and meta-analysis
Authors: de Liyis Bryan Gervais , Suastika Luh Oliva Saraswati , Sutedja Jane Carissa , Jagannatha Gusti Ngurah Prana , Kosasih Anastasya Maria , Alamsyah Alif Hakim 
Published: August 2024

Abstract
Background
Echocardiographic prognostic indicators of precapillary pulmonary hypertension (PH) mortality has been inconclusive. This study aims to examine the prognostic values of right ventricular echocardiographic functional parameters in predicting precapillary PH mortality.

Methods
Systematic searches were conducted in the ScienceDirect, Medline, and Cochrane databases for longitudinal studies. Assessments included means and hazard ratios (HRs) for Tricuspid Annular Plane Systolic Excursion (TAPSE), Right Ventricular Systolic Pressure (RVSP), Right Ventricular Longitudinal Strain (RVLS), Right Ventricular Fractional Area Change (RVFAC), Right Ventricular Ejection Fraction (RVEF), and Right Ventricular Index of Myocardial Performance (RIMP).

Results
The meta-analysis included 24 cohort studies comprising 2171 participants. Mean values were as follows: TAPSE 17.62 mm, RVSP 77.50 mmHg, RVLS − 16.78%, RVFAC 29.81%, RVEF 37.56%, and RIMP 0.52. TAPSE (HR: 1.28; 95% CI 1.17–1.40; p < 0.001), RVLS (HR: 1.74; 95% CI 1.34–2.26; p < 0.001), RVFAC (HR: 1.40; 95% CI 1.13–1.75; p < 0.001), RVEF (HR: 1.08; 95% CI 1.02–1.15; p = 0.01), and RIMP (HR: 1.51; 95% CI 1.23–1.86; p < 0.001) emerged as significant prognosticators of precapillary PH mortality, with the exception of RVSP (HR: 1.04; 95% CI 0.99–1.09; p = 0.14). TAPSE summary receiver operating characteristics (sROC) analysis yielded an area under the curve (AUC) of 0.85 [95% CI 0.81–0.88] with a sensitivity of 0.81 [95% CI 0.63–0.91] and a specificity of 0.74 [95% CI 0.54–0.87]. RVLS sROC resulted in an AUC of 0.74 [95% CI 0.70–0.78] with a sensitivity of 0.74 [95% CI 0.57–0.86] and a specificity of 0.69 [95% CI 0.64–0.75].

Conclusions
TAPSE, RVLS, RVFAC, RVEF, and RIMP demonstrated promise as valuable prognostic indicators for precapillary PH mortality.