bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of endogenous NOTCH1 from POFUT1 S162L patient fibroblasts reveals the importance of the O-fucose modification on EGF12 in human development
Authors: Matsumoto Kenjiroo , Luther Kelvin B , Haltiwanger Robert S 
Published: July 2024

Abstract
NOTCH1 is a transmembrane receptor interacting with membrane-tethered ligands on opposing cells that mediate the direct cell–cell interaction necessary for many cell fate decisions. Protein O-fucosyltransferase 1 (POFUT1) adds O-fucose to Epidermal Growth Factor (EGF)-like repeats in the NOTCH1 extracellular domain, which is required for trafficking and signaling activation. We previously showed that POFUT1 S162L caused a 90% loss of POFUT1 activity and global developmental defects in a patient; however, the mechanism by which POFUT1 contributes to these symptoms is still unclear. Compared to controls, POFUT1 S162L patient fibroblast cells had an equivalent amount of NOTCH1 on the cell surface but showed a 60% reduction of DLL1 ligand binding and a 70% reduction in JAG1 ligand binding. To determine if the reduction of O-fucose on NOTCH1 in POFUT1 S162L patient fibroblasts was the cause of these effects, we immunopurified endogenous NOTCH1 from control and patient fibroblasts and analyzed O-fucosylation using mass spectral glycoproteomics methods. NOTCH1 EGF8 to EGF12 comprise the ligand binding domain, and O-fucose on EGF8 and EGF12 physically interact with ligands to enhance affinity. Glycoproteomics of NOTCH1 from POFUT1 S162L patient fibroblasts showed WT fucosylation levels at all sites analyzed except for a large decrease at EGF9 and the complete absence of O-fucose at EGF12. Since the loss of O-fucose on EGF12 is known to have significant effects on NOTCH1 activity, this may explain the symptoms observed in the POFUT1 S162L patient.
Assessment of window renovation potential in an apartment with an energy performance approach
Authors: Pekdogan Tugce , Yildizhan Hasan , Ahmadi Mohammad Hossein , Sharifpur Mohsen 
Published: July 2024

Abstract
Windows are of great importance in improving the energy efficiency of buildings. It is possible to achieve this with the help of the regeneration of window design. The amount of energy used, the expense of heating and cooling, and the emissions of greenhouse gases that contribute to climate change can all be significantly reduced by improving the energy efficiency of windows. For this, computer modeling and BIM-based simulation programs provide significant timesaving in simultaneously evaluating design variations’ visual and thermal results. This study selected a four-story residential building to analyze the energy load and thermal comfort of the windows redesign and examine the energy-saving potential for residential buildings. To analyze the renewed window design strategies, a four-story apartment building is selected as a case study in Izmir/Turkey (38° 4′, 27° 2′). This apartment is built on a 90 m2 gross floor area. The existing indoor environmental conditions of the flat are generally observed as cool and low illuminated by the occupants, so the window design options must be compared and renewed. As the first option, current conditions are simulated. The second option is to simulate different patterns for window-to-wall ratio (WWR). Moreover, the third option is to simulate different types of glass in each window. Currently, the WWR of the selected flat in the north, east and south directions is around 10%. But more is needed to provide daylight to the apartment. This article used Autodesk Revit and Green Building Studio simulations to investigate WWR and glass types and evaluate energy use intensity’s (EUI) impact. As a result, this study shows that a 10% WWR on all building facades leads to an EUI of 993.9 MJ/m2/year. In contrast, increasing the WWR to 95% significantly increased EUI, reaching 2121 MJ/m2/year. In addition, it has been shown that the use of low U-value glasses, such as translucent wall panels and super-insulated three-pane clear Low-E, can provide energy savings of up to 5% per year, and especially the super-insulated three-pane Low-E glass type provides the highest efficiency on all facades.
A Credibility Divide? Discerning Truth From Misinformation in Chile
Authors: Bachmann Ingrid , Valenzuela Sebastián , Mujica Constanza , Labarca Claudia , Grassau Daniela , Halpern Daniel 
Published: July 2024

Abstract
Studies on misinformation often overlook people’s assessment of true information, focusing instead on beliefs in and sharing of false content. This is problematic, as it limits scholars’ ability to produce an accurate assessment of citizens’ capacity to distinguish between true and false content. To shed light on this matter, this study relies on a two-wave online survey (Nrespondents = 465) to examine people’s truth discernment, that is, how much they believe and share true content relative to false content. It does so in Chile over two different crises: after the 2019 protests (Wave 1, November 2019), and at the early stages of the COVID-19 pandemic (Wave 2, May–June 2020). While true information was deemed credible more often than false information, discernment tended to be better for those who had a better perception of traditional media content and those more politically engaged. Conversely, credibility and sharing of false content tended to be more common with younger people and those with high levels of trust in social media. Over time, levels of credibility and sharing discernment remained stable.
Global Misinformation & Disinformation Special Issue Introduction
Authors: Lukito Josephine 
Published: July 2024

AbstractThis introductory article discusses the current state of scholarship about global misinformation and disinformation, highlighting key actors that researchers study, common research questions, and differences between within-country and between-country mis/disinformation. It also provides an overview of the 8 submissions in the International Journal of Public Opinion’s special issue on Global Misinformation and Disinformation.
Gendering Zoom Diplomacy: Women’s Participation in Digital Diplomacy
Authors: Donovan Outi 
Published: July 2024

Abstract
In the wake of the COVID-19 pandemic and the subsequent emergence of “Zoom diplomacy,” scholarship on digital diplomacy has shifted attention from the nexus between social media and foreign policy to exploring the use of digital technologies in diplomatic encounters. While these studies have generated important insights on the affordances and limitations of digital diplomacy, we know much less about the impact of digitalization on the gendered hierarchies and power dynamics that characterize diplomatic practices. In what ways does digitalization of diplomacy shape these hierarchical and gendered practices of diplomacy? In taking stock of recent empirical findings on digital diplomacy, the analysis reviews the varied effects of digitalization on women’s diplomatic agency. Focusing on peace diplomacy, it suggests that digitalization of diplomacy produces ambivalent agency where digitalization opens up some opportunities for disrupting gendered diplomatic practices, but within patriarchal gender structures. The analysis highlights the ways in which digital diplomatic agency and competence are shaped by gendered material and normative structures, suggesting that on the borders of what is conventionally regarded as diplomacy, digitalization may be reinforcing diplomacy as a masculine practice.
On-Field Rule Out of Mild Traumatic Brain Injury: Can Blood-Based Biomarker Testing Change Outcome of Major Sporting Events?
Authors: Wu Alan H B , Peacock W Franklin 
Published: July 2024

Abstract

Background
Mild traumatic brain injury (mTBI) is defined as a Glascow Coma Score of between 13 and 15. The diagnosis and rule out of individuals suffering from mTBI on an acute basis is imperfect and involves subjective measures. Serum biomarkers that exhibit narrow within-individual biological variation can be used for the early rule-out of mTBI, when baseline levels are compared during health.

Methods
This is a descriptive study that applies published biological variation data of serum mTBI biomarkers for early rule out of sports-related injury.

Results
Laboratory tests such as glial fibrillary acidic protein, fatty acid binding protein 7, and phosphorylated protein enriched in astrocytes have low within-individual variances and are potential candidates. Aldolase C also rises early in blood but the biological variation is of this marker is currently unknown.

Conclusions
The use of blood-based biomarkers, measured in real time using point-of-care testing devices when compared to a pre-competition baseline instead of a population-based reference interval, can provide early rule out of mTBI, and possibly enable on-field evaluations and a medical decision for a return to competition.
The comparative effect of teriparatide and denosumab on activins, follistatins, and inhibins in women with postmenopausal osteoporosis
Authors: Anastasilakis Athanasios D , Polyzos Stergios A , Makras Polyzois , Savvidis Matthaios , Mantzoros Christos S 
Published: July 2024

Abstract
The activins–follistatins–inhibins (AFI) hormonal system affects bone metabolism. Treatments that alter bone metabolism may also alter the AFI molecules. In this non-randomized, open-label, head-to-head comparative study, circulating levels of the AFI system were evaluated in postmenopausal women with osteoporosis treated for 12 mo with either teriparatide (n = 23) or denosumab (n = 22). Τeriparatide treatment increased activin B (P=.01) and activin AB (P=.004) and the ratios activin A/follistatin (P=.006), activin B/follistatin (P=.007), activin AB/follistatin (P&lt;.001), and activin AB/ follistatin-like 3 (FSTL3) (P=.034). The significant P for trend in group × time interactions of activins B and AB and of the ratio activin AB/FSTL3 remained robust after adjustment for BMI and LS BMD but it was lost for activin B after adjustment for previous antiresorptive treatment. The effect of teriparatide on BMD was attenuated when it was adjusted for baseline activins levels or their 12-mo changes. No changes were observed after denosumab treatment. In conclusion, activins B and AB, as well as the ratios of all activins to follistatin and of activin AB to FSTL3 increased with teriparatide treatment, possibly in a compensatory manner. Future studies are needed to study the potentially important role activins may play in bone biology and any associations with the effect of teriparatide on BMD.
Clinical Trials identifier: NCT04206618. ClinicalTrials.gov https://clinicaltrials.gov/search?term=NCT04206618.
Looters to collectors
Authors: Hill Katrina 
Published: July 2024

Abstract
During the plunder of the Summer Palace in Beijing (commonly ‘Pekin’ in English until the 1890s) by the Anglo-French army in 1860, soldiers of the British forces acquired imperial objects. They repurposed these at home in Britain as commodities, trophies and decorative art. This essay takes a critical look at their activities as collecting – the purposeful selection and assembly of objects – and considers the tastes and priorities that were factors in the selection of treasures from the imperial estate; it then examines how, in the hands of soldiers, dealers and collectors, new meanings accrued to objects that were economic, political and aesthetic. This collecting history is told through case studies involving exhibitions, designed interiors and auctions at which objects from the Summer Palace figured, and situates these within the wider collecting and exhibition cultures of the later nineteenth century. The facts show that soldiers’ collections of Summer Palace material not only fed the art market, but also had a formative impact on the understanding and valuation of the objects in the marketplace.
Effectiveness of Participatory Research Interventions on Obesity and Obesity-Related Behaviors in Adolescents: A Systematic Review and Meta-analysis
Authors: Queral Judit , Wargers Annemieke , Llauradó Elisabet , Jansen Wilma , Solà Rosa , Tarro Lucia , Mölenberg Famke J M 
Published: July 2024

Abstract

Context
Adolescence is an optimal period to promote healthy lifestyles because behavior patterns are established in this stage. It has been suggested that engaging youth increases the effectiveness of interventions, but an overview is lacking.

Objective
This study aims to evaluate the effectiveness of participatory research (PR) interventions, where adolescents (11–18 years old) from high-income countries had a significant role in the intervention development and/or delivery, compared with no (PR) intervention control groups on obesity-related outcomes and healthy lifestyle behaviors (HLBs).

Data Sources
Eight databases (Embase, Medline ALL, Web of Science Core Collection, PsycINFO, ERIC, CINAHL, Scopus, and Cochrane Central Register of Controlled Trials) and Google Scholar were searched from 1990 to 2024 for randomized controlled trials (RCTs) and non-RCTs (in English).

Data Extraction
Two researchers independently performed the data extraction and risk-of-bias assessment.

Data Analysis
Sixteen studies were included and outcomes have been narratively described. Seven studies evaluated youth-led interventions, 3 studies evaluated co-created interventions, and 6 studies evaluated the combination of both. Six studies focused on physical activity (PA), 2 on nutrition, and 8 on a combination of PA, nutrition, and/or obesity-related outcomes. Ten studies presented at least 1 significant effect on PA, nutrition, or obesity-related outcomes in favor of the intervention group. Additionally, 12 studies were pooled in a meta-analysis. Whereas a small desired effect was found for fruit consumption, a small undesired effect was found for vegetable consumption. The pooled analysis found no significant effects on moderate–vigorous PA, total PA, and PA self-efficacy.

Conclusion
We found some evidence that youth empowerment in research may have positive effects on obesity-related HLBs, specifically an increased fruit consumption. However, the overall evidence was inconclusive due to limited studies and the heterogeneity of the studies included. This overview may guide future public health interventions that aim to engage and empower adolescents.

Systematic Review Registration
PROSPERO registration Nº CRD42021254135.
Guaranteed storage? Risk and credit constraints in the demand for postharvest technology
Authors: Schwab Benjamin , Yu Jisang 
Published: July 2024

Abstract
Uninsured risk is often cited to explain the lagging adoption of new agricultural technologies in low-income regions. However, insurance interventions suffer from poor take-up. We test whether bundling a new product–hermetic storage bags–with a warranty can serve as a viable alternative. We compare the warranty to a credit intervention and a control using an incentivized auction in rural Bangladesh. We find the warranty had no impact on demand. Providing the bags on credit significantly increased willingness-to-pay, and machine learning estimates indicate credit may have raised the demand for the most marginal farmers. Warranties failed to stimulate demand along any dimension.
Male genital self-image, premature ejaculation, and affecting factors
Authors: Koçak Vesile , Tufan Osman 
Published: July 2024

Abstract

Background
Negative genital self-image is associated with sexual unresponsiveness and dysfunction.

Aim
This study aims to determine the relationship between men’s genital self-image and premature ejaculation, with identifying influencing factors.

Methods
The research is designed as a descriptive and correlational study. The sample consists of 188 men aged 18 to 60 years who volunteered to participate in the study.

Outcomes
A negative correlation was observed between genital self-image and premature ejaculation (P &lt; .05).

Results
The average age of the participating men was 39.5 ± 9.79 years (mean ± SD), with 91.5% being married. The average age of the participants’ first sexual encounter was 20.43 ± 4.01 years, and 38.3% reported experiencing premature ejaculation. The mean score for the Male Genital Self-image Scale was 21.10 ± 5.59, and that for the Premature Ejaculation Diagnostic Tool was 6.96 ± 3.73. As a result of the study, it was revealed that participants who experienced premature ejaculation were not at peace with their bodies and were dissatisfied with their sexual experiences and their genital size and function, with significantly lower levels of genital self-image (P &lt; .05).

Clinical Implications
Identifying factors that affect men’s genital self-image is crucial for maintaining sexual functions.

Strengths and Limitations
In Turkey, sexuality is a taboo subject, often considered shameful and rarely discussed, making it challenging to find participants willing to engage in research.

Conclusion
Men’s genital self-image influences the characteristics of premature ejaculation.
Integrative analysis of transcriptome and metabolome reveal the differential tolerance mechanisms to low and high salinity in the roots of facultative halophyte Avicennia marina
Authors: Li Jing , Xu Chao-Qun , Song Ling-Yu , Guo Ze-Jun , Zhang Lu-Dan , Tang Han-Chen , Wang Ji-Cheng , Song Shi-Wei , Liu Jing-Wen , Zhong You-Hui , Chi Bing-Jie , Zhu Xue-Yi , Zheng Hai-Lei 
Published: July 2024

Abstract
Mangroves perform a crucial ecological role along the tropical and subtropical coastal intertidal zone where salinity fluctuation occurs frequently. However, the differential responses of mangrove plant at the combined transcriptome and metabolome level to variable salinity are not well documented. In this study, we used Avicennia marina (Forssk.) Vierh., a pioneer species of mangrove wetlands and one of the most salt-tolerant mangroves, to investigate the differential salt tolerance mechanisms under low and high salinity using inductively coupled plasma-mass spectrometry, transcriptomic and metabolomic analysis. The results showed that HAK8 was up-regulated and transported K+ into the roots under low salinity. However, under high salinity, AKT1 and NHX2 were strongly induced, which indicated the transport of K+ and Na+ compartmentalization to maintain ion homeostasis. In addition, A. marina tolerates low salinity by up-regulating ABA signaling pathway and accumulating more mannitol, unsaturated fatty acids, amino acids' and L-ascorbic acid in the roots. Under high salinity, A. marina undergoes a more drastic metabolic network rearrangement in the roots, such as more L-ascorbic acid and oxiglutatione were up-regulated, while carbohydrates, lipids and amino acids were down-regulated in the roots, and, finally, glycolysis and TCA cycle were promoted to provide more energy to improve salt tolerance. Our findings suggest that the major salt tolerance traits in A. marina can be attributed to complex regulatory and signaling mechanisms, and show significant differences between low and high salinity.
A randomized phase 2b study of subcutaneous PD-L1 antibody ASC22 in virally suppressed patients with chronic hepatitis B who are HBeAg-negative
Authors: Qian Jiandan , Xie Yao , Mao Qianguo , Xie Qing , Gu Ye , Chen Xinyue , Hu Guoxin , Yang Yongfeng , Lu Jiajie , Zou Guizhou , Zhang Qin , Fu Lei , Chen Yongping , Guo Xiaolin , Hou Jinlin , Yan Yuemei , Wu Jinzi J. , Cui Yimin , Wang Guiqiang 
Published: July 2024

Background and Aims:
Studies have shown that blocking the programmed cell death-1/programmed cell death ligand 1 pathway may lead to a potential cure for HBV infections. ASC22 (envafolimab) is a humanized, single-domain programmed cell death ligand 1 antibody administered subcutaneously. This study aimed to evaluate the efficacy and safety of ASC22 in virally suppressed patients with chronic hepatitis B on nucleos(t)ide analogs.

Approach and Results:
This randomized, single-blind, phase IIb trial enrolled patients with chronic hepatitis B in 2 cohorts for a 24-week treatment with ASC22 or placebo (PBO) once every 2 weeks and 24-week follow-up. In total, 60, 59, and 30 patients were treated with 1.0, 2.5 mg/kg ASC22, and PBO, respectively. The mean changes in HBsAg from baseline at weeks 24 and 48 were −0.309 (p < 0.001) and −0.272 (p < 0.023) log10 IU/mL in the 1.0 mg/kg ASC22 group, −0.231 (p = 0.007) and −0.205 (p = 0.12) log10 IU/mL in the 2.5 mg/kg ASC22 group, and −0.003 and −0.063 log10 IU/mL in the PBO group, respectively (intent-to-treat population). Three out of 10 patients with baseline HBsAg levels ≤100 IU/mL in the 1.0 mg/kg group obtained on-treatment HBsAg loss. Most adverse events were mild (97.9%). There were no study drug–related serious adverse events in the 1.0 mg/kg ASC22 group.

Conclusions:
Subcutaneous administration of 1.0 mg/kg ASC22 once every 2 weeks for 24 weeks was shown to be safe and well-tolerated in virally suppressed patients with chronic hepatitis B on nucleos(t)ide analogs and can induce HBsAg decline, especially in patients with HBsAg ≤100 IU/mL.
Contralateral differences in ankle SBP and pulse wave velocity: associations with incident heart failure and mortality
Authors: Charry Daniela , Xu Jing , Meyer Michelle L. , Kucharska-Newton Anna , Matsushita Kunihiro , Tanaka Hirofumi 
Published: July 2024

Background:
Contralateral differences in brachial SBP are indicative of underlaying cardiovascular issues.

Objectives:
To examine the association of contralateral differences in ankle SBP, brachial-ankle pulse wave velocity (baPWV), and heart-ankle pulse wave velocity (haPWV) with incident heart failure and all-cause and cardiovascular mortality.

Methods:
Cox proportional-hazards models were used to calculate hazard ratios and 95% confidence intervals (95% CIs) in 5077 participants (75 ± 5 years) of the Atherosclerosis Risk in Communities study.

Results:
Over a mean follow-up of 7.5 ± 2.2 years, there were 457 heart failure events, 1275 all-cause and 363 cardiovascular deaths. Interankle SBP difference of at least 10 mmHg [hazard ratio = 1.12; confidence interval (CI) 1.00–1.28], at least 15 mmHg (hazard ratio = 1.21; CI 1.03–1.43), contralateral difference in baPWV more than 240 cm/s (hazard ratio = 1.22; CI 1.02–1.46), and haPWV more than 80 cm/s (hazard ratio = 1.24; CI 1.04–1.48) were each independently associated with all-cause mortality after adjustment for confounders. Contralateral differences in ankle SBP of at least 15 mmHg (hazard ratio = 1.56; CI 1.17–2.09), and haPWV more than 80 cm/s (hazard ratio = 1.42; CI 1.03–1.96) were both independently associated with cardiovascular mortality. Unadjusted analysis revealed that those with contralateral differences in ankle SBP of at least 10 and at least 15 mmHg, baPWV more than 240, and haPWV more than 80 cm/s had higher risks of heart failure (all P < 0.05).

Conclusion:
These results underscore the significance of evaluating contralateral differences in ankle SBP and PWV as potential markers of increased mortality risk among older adults.