bluuebunny/crossref_metadata_2025_split huggingface dataset:
Prevalence of platelet‐specific antibodies and efficacy of crossmatch‐compatible platelet transfusions in refractory patients
Authors: Jia Y. , Li W. , Liu N. , Zhang K. , Gong Z. , Li D. , Wang L. , Wang D. , Jing Y. , Wang J. , Shan X. 
Published: October 2014

SUMMARYBackgroundThe development of specific antibodies against human leukocyte antigen (HLA) and/or human platelet antigen (HPA) could induce platelet transfusion refractoriness especially in patients receiving multiple platelet transfusions. A retrospective analysis was conducted to evaluate the prevalence of platelet‐specific antibodies and the efficacy of crossmatch‐compatible platelet transfusions in these recipients.Study Design and MethodsAll enrolled patients were refractory to random single‐donor apheresis Platelet (PLT) units. Enzyme‐linked immunosorbent assay (ELISA) was used to detect anti‐HLA and anti‐HPA antibodies in serum. For those patients with antibodies, the PLT crossmatch assays were performed to select the compatible PLTs with a commercial solid‐phase adherence kit.ResultsA total of 193 patients were included and 29·02% of which was HLA and/or HPA antibody‐positive. There were no significant differences in antibody‐positive rates among AML/CML, ALL/CLL, MDS, SAA and ITP groups, but they are statistically significantly higher than other groups (P = 0·0035). Of those antibody‐positive patients, there were 41 (73·21%) patients with only HLA antibodies, 11 (19·64%) patients with only HPA antibodies and 4 (7·14%) patients with both HLA and HPA antibodies. A total of 43 random PLT units and 88 crossmatch‐compatible PLT units were administered. The mean (±SD) corrected count increment (CCI) was 8700 (±4500) after crossmatch‐compatible unit transfusion, significantly higher than 3600 (±2400) for random PLT units (P < 0·001).ConclusionsHLA and/or HPA alloimmunisation is an important factor to cause refractoriness to platelet transfusions. Crossmatch‐compatible platelet transfusion is an effective method in those patients refractory to random platelet transfusions.
The contribution of unimproved water and toilet facilities to pregnancy‐related mortality in Afghanistan: analysis of the Afghan Mortality Survey
Authors: Gon Giorgia , Monzon‐Llamas Laura , Benova Lenka , Willey Barbara , Campbell Oona M. R. 
Published: October 2014

AbstractObjectiveTo estimate the effect of unimproved household water and toilet facilities on pregnancy‐related mortality in Afghanistan.MethodsThe data source was a population‐based cross‐sectional study, the Afghan Mortality Survey 2010. Descriptive, univariate and multivariate logistic regression analyses were carried out, comparing 69 pregnancy‐related deaths (cases) and 15386 surviving women (non‐cases) who had a live birth or stillbirth between 2007 and 2010.ResultsAfter adjusting for confounders, households with unimproved water access had 1.91 the odds of pregnancy‐related mortality [95% confidence interval (CI) 1.11–3.30] compared to households with improved water access. We also found an association between unimproved toilet facilities and pregnancy‐related mortality (OR = 2.25; 95% CI 0.71–7.19; P‐value = 0.169), but it was not statistically significant.ConclusionsUnimproved household water access was an important risk factor for pregnancy‐related mortality in Afghanistan. However, we were unable to discern whether unimproved water source is a marker of unhygienic environments or socio‐economic position. There was weak evidence for the association between unimproved toilet facilities and pregnancy‐related mortality; this association requires confirmation from larger studies.
Dengue outbreaks in Divinopolis, south‐eastern Brazil and the geographic and climatic distribution ofAedes albopictusandAedes aegyptiin 2011–2012
Authors: da Rocha Taranto Martinelle Ferreira , Pessanha José Eduardo Marques , dos Santos Michelli , dos Santos Pereira Andrade Ana Cláudia , Camargos Vidyleison Neves , Alves Stênio Nunes , Di Lorenzo Oliveira Cláudia , Taranto Alex Gutterres , dos Santos Luciana Lara , de Magalhães José Carlos , Kroon Erna Geessien , Figueiredo Leandra Barcelos , Drumond Betânia Paiva , Ferreira Jaqueline Maria Siqueira 
Published: October 2014

AbstractObjectiveTo entomologically monitorAedesspp. and correlate the presence of these vectors with the recent epidemic of dengue in Divinopolis, Minas Gerais State, Brazil.MethodsOvitraps were installed at 44 points in the city, covering six urban areas, from May 2011 to May 2012. After collection, the eggs were incubated until hatching. In the 4th stage of development, the larvae were classified asAe. aegyptiorAe. albopictus.ResultsIn total, 25 633Aedesspp. eggs were collected. February was the month with the highest incidence, with 5635 eggs collected and a hatching rate of 46.7%.Ae. aegyptieggs had the highest hatching rate, at 72.3%, whereasAe. albopictuseggs had 27.7%. Climate and population density influenced the number of eggs found. Indicators of vector presence were positively correlated with the occurrence of dengue cases.ConclusionThese data reinforce the need for entomological studies, highlight the relevance ofAe. albopictusas a possible disease vector and demonstrate its adaptation.Ae. albopictus, most commonly found in forested areas, comprised a substantial proportion of the urban mosquito population.
Richer but fatter: the unintended consequences of microcredit financing on household health and expenditure in Jamaica
Authors: Gordon–Strachan Georgiana , Cunningham‐Myrie Colette , Fox Kristin , Kirton Claremont , Fraser Raphael , McLeod Georgia , Forrester Terrence 
Published: October 2014

AbstractObjectiveTo determine whether there was a difference in wealth and cardiovascular disease (CVD) risk between microcredit loan beneficiaries and community‐matched non‐beneficiaries (controls).MethodsSeven hundred and twenty‐six households of microcredit loan beneficiaries were matched with 726 controls by age, sex and community. A standardised interviewer administered questionnaire was used to collect data on health and household expenditure. Weights, heights, waist circumference and blood pressure measurements were taken for an adult and one child (6–16 years) from each household.ResultsAmongst adults, there was no difference in the prevalence of pre‐hypertension and hypertension. More male (68.1% vs. 47.8%) and female beneficiaries (84.5% vs. 77.9%) were overweight/obese. More male (17.2% vs. 7.1%; P < 0.05) and female beneficiaries (68.5% vs. 63.3%; P < 0.05) exhibited substantially increased risk for CVD. Children of beneficiaries displayed higher mean BMI‐for‐age z‐scores than their control peers: males 0.56 [95% CI 0.40–0.72] vs. 0.18 [95% CI 0.02–0.35] (P < 0.001) and females 0.66 [95% CI 0.52–0.80] vs. 0.42 [95% CI 0.29–0.56] (P < 0.001). Based on BMI‐for‐age z‐scores, children of beneficiaries had greater odds of being overweight/obese (OR = 1.46; 95% CI 1.18–1.82) Beneficiaries were economically better off; their mean total annual expenditure and house ownership were significantly higher than controls (P < 0.001).ConclusionsMicrocredit financing is positively associated with wealth acquisition but worsened cardiovascular risk status.
Delayed cord clamping in South African neonates with expected low birthweight: a randomised controlled trial
Authors: Tiemersma Sybrich , Heistein Julia , Ruijne Roos , Lopez Gustavo , van Lobenstein Jeroen , van Rheenen Patrick 
Published: October 2014

AbstractObjectiveTo evaluate safety and haematological effects of delayed cord clamping (DCC) in infants with expected low birthweight born in a resource‐poor setting.MethodsRandomised controlled trial involving pregnant women in early labour ≥18 years with intrapartum symphysal‐fundal height ≤32 cm. Mothers were randomised for either early cord clamping (ECC, <30 s) or DCC (2–3 min after birth).ResultsWe included 104 vigorous infants born by vaginal delivery, of whom 39% had a birthweight <2500 g. Infant haemoglobin (Hb) levels 24 h after birth were significantly higher in the DCC group (18.0 g/dl vs 16.8 g/dl, P = 0.006). Despite successful placental transfusion, hyperbilirubinemia and hyperviscosity were not observed. Two months after birth, there were no differences in Hb between groups (9.9 g/dl vs 9.8 g/dl, P = 0.60), but the infants in the DCC group had better weight gain from baseline than those with ECC (2.2 kg vs 1.9 kg, P = 0.058).ConclusionsIn this South African cohort of newborns with a subnormal distribution of birthweight delayed cord clamping was a safe procedure. Two months after birth the effect of DCC on Hb was not detectable anymore. DCC should be promoted in every singleton delivery in a resource‐poor setting irrespective of the birthweight.
From Gesture to Sign Language: Conventionalization of Classifier Constructions by Adult Hearing Learners of British Sign Language
Authors: Marshall Chloë R. , Morgan Gary 
Published: October 2014

AbstractThere has long been interest in why languages are shaped the way they are, and in the relationship between sign language and gesture. In sign languages, entity classifiers are handshapes that encode how objects move, how they are located relative to one another, and how multiple objects of the same type are distributed in space. Previous studies have shown that hearing adults who are asked to use only manual gestures to describe how objects move in space will use gestures that bear some similarities to classifiers. We investigated how accurately hearing adults, who had been learning British Sign Language (BSL) for 1–3 years, produce and comprehend classifiers in (static) locative and distributive constructions. In a production task, learners of BSL knew that they could use their hands to represent objects, but they had difficulty choosing the same, conventionalized, handshapes as native signers. They were, however, highly accurate at encoding location and orientation information. Learners therefore show the same pattern found in sign‐naïve gesturers. In contrast, handshape, orientation, and location were comprehended with equal (high) accuracy, and testing a group of sign‐naïve adults showed that they too were able to understand classifiers with higher than chance accuracy. We conclude that adult learners of BSL bring their visuo‐spatial knowledge and gestural abilities to the tasks of understanding and producing constructions that contain entity classifiers. We speculate that investigating the time course of adult sign language acquisition might shed light on how gesture became (and, indeed, becomes) conventionalized during the genesis of sign languages.
Epidemiology of Injuries in High School Football: Does School Size Matter?
Authors: King Harold , Campbell Stephen , Herzog Makenzie , Popoli David , Reisner Andrew , Polikandriotis John 
Published: October 2014

Background:More than 1 million US high school students play football. Our objective was to compare the high school football injury profiles by school enrollment size during the 2013–2014 season.Methods:Injury data were prospectively gathered on 1806 student athletes while participating in football practice or games by certified athletic trainers as standard of care for 20 high schools in the Atlanta Metropolitan area divided into small (<1600 students enrolled) or large (≥1600 students enrolled) over the 2013–2014 football season.Results:Smaller schools had a higher overall injury rate (79.9 injuries per 10,000 athletic exposures vs. 46.4 injuries per 10,000 athletic exposures; P < .001). In addition, smaller schools have a higher frequency of shoulder and elbow injuries (14.3% vs. 10.3%; P = .009 and 3.5% vs. 1.5%; P = .006, respectively) while larger schools have more hip/upper leg injuries (13.3% vs. 9.9%; P = .021). Lastly, smaller schools had a higher concussion distribution for offensive lineman (30.6% vs. 13.4%; P = .006) and a lower rate for defensive backs/safeties (9.2% vs. 25.4%; P = .008).Conclusions:This study is the first to compare and show unique injury profiles for different high school sizes. An understanding of school specific injury patterns can help drive targeted preventative measures.
Deterministic Parallel MaxSAT Solving
Authors: Martins Ruben , Manquinho Vasco , Lynce Inês 
Published: October 2014

Multicore processors are becoming the dominant platform in modern days. As a result, parallel Maximum Satisfiability (MaxSAT) solvers have been developed to exploit this new architecture. However, parallel MaxSAT solvers suffer from non-deterministic behavior, i.e. several runs of the same solver can lead to different solutions. This is a clear downside for applications that require solving the same problem instance more than once. This paper presents the first deterministic parallel MaxSAT solver that ensures reproducibility of results. Experimental results show that the performance of the new deterministic solver is comparable to the corresponding non-deterministic version.Another advantage of using a deterministic solver is the fact that one can easily observe the gains coming from different techniques, since the non-determinism is removed from the solver. For example, sharing learned clauses in parallel MaxSAT is expected to help to further prune the search space and boost the performance of a parallel solver. Yet, so far it has not been made clear which learned clauses should be shared among the different threads. By using the deterministic solver, we present a comparison showing that sharing learned clauses improves the overall performance of parallel MaxSAT solvers.
INTERACTIONS BY EXCHANGE OF VOLUME BETWEEN TWO SPHERICAL BUBBLES
Authors: ADAMA MAIGA M. , COUTIER-DELGOSHA O. , BUISINE D. 
Published: October 2014

In this paper, by using the system potential of two bubbles and with a special interest in the interaction by exchange of volume and without exchange of mass, a system of equations governing the evolution of two bubbles is proposed. This two-bubble model shows terms that do not appear in the models of interaction between bubbles. The two-bubble model is compared with the modified Rayleigh–Plesset equation and a validation with the experimental study of Ohl [2002] is presented. The numerical results show that, on one hand, the development of small nearby bubbles can slow down the evolution of the biggest local one, while their disappearance can favor its growing. Furthermore, in the case of two bubbles in particular, the small bubble exchanges volume with the big one during their evolutions. On the other hand, contrary to the modified Rayleigh–Plesset model, the two-bubble model predicts appearance and disappearance of small bubbles in the neighborhood of the big bubble as it is observed in the experimental study of Ohl [2002]. The present findings show in particular that the interaction by exchange of volume can be very important in the cavitation born phase and it is necessary to take into account the interaction between bubbles as well as the disappearance of small ones on the evolution of the biggest local bubble. Also, this two-bubble model predicts an exchange of volume between both bubbles equal to zero when they are perfectly identical.
CHARACTERIZATION OF COHESIVE LAWS FOR FOAM-METAL INTERFACES
Authors: KRAUS BENJAMIN , DAS RAJ , BANERJEE BISWAJIT 
Published: October 2014

Numerical prediction of mixed-mode failure along interfaces between polymeric foams and metals in foam-filled composite structures can be facilitated if interfacial cohesive laws are known. In this paper, we characterize the cohesive behavior of the interface between a polyurethane (PU) closed-cell foam and galvanized mild steel by extending an experimental approach suggested by [Lundsgaard–Larsen et al. [2008] Engineering Fracture Mechanics 75(8), 2514–2530]. A simplified approach for calculating the fracture energy and for extracting cohesive relations from the fracture energy-total crack opening displacement data is presented. We find that there is a substantial amount of normal separation in tests that are designed to be purely mode II, and a small amount of tangential motion in tests designed to be purely mode I. The interfacial cohesive laws extracted from our experiments suggest that the normal traction depends not only the normal and tangential displacements but also the tangential traction.
Clinical Presentation and Microarray Analysis of Peruvian Children with Atypical Development and/or Aberrant Behavior
Authors: Butler Merlin G. , Usrey Kelly , Roberts Jennifer L. , Schroeder Stephen R. , Manzardo Ann M. 
Published: October 2014

We report our experience with high resolution microarray analysis in infants and young children with developmental disability and/or aberrant behavior enrolled at the Centro Ann Sullivan del Peru in Lima, Peru, a low income country. Buccal cells were collected with cotton swabs from 233 participants for later DNA isolation and identification of copy number variation (deletions/duplications) and regions of homozygosity (ROH) for estimating consanguinity status in 15 infants and young children (12 males, 3 females; mean age ± SD = 28.1 m±  7.9 m; age range 14 m–41 m) randomly selected for microarray analysis. An adequate DNA yield was found in about one-half of the enrolled participants. Ten participants showed deletions or duplications containing candidate genes reported to impact behavior or cognitive development. Five children had ROHs which could have harbored recessive gene alleles contributing to their clinical presentation. The coefficient of inbreeding was calculated and three participants showed first-second cousin relationships, indicating consanguinity. Our preliminary study showed that DNA isolated from buccal cells using cotton swabs was suboptimal, but yet in a subset of participants the yield was adequate for high resolution microarray analysis and several genes were found that impact development and behavior and ROHs identified to determine consanguinity status.
New records of Bodotriidae (Crustacea: Cumacea) from Puerto Rico with descriptions of three new species
Authors: PETRESCU IORGU , CHATTERJEE TAPAS , SCHIZAS NIKOLAOS V. 
Published: October 2014

In a continuing effort to describe the cumacean fauna of Puerto Rico we describe three new species of Bodotriidae, a family that has never been reported from Puerto Rico before. While finding and describing new microcrustacean species may not be an impossible task, if there is available taxonomic expertise, the currently described species were found in large numbers within a short distance from the Marine Laboratories of the University of Puerto Rico where the local reefs have been studied for over half a century, highlighting the large gaps that exist in our estimates of Caribbean marine diversity. The three new species, Cyclaspis gurui sp. nov., Cyclaspis mariae sp. nov. and Vaunthompsonia budaii sp. nov. are reported from a fringing reef off La Parguera, southwest coast of Puerto Rico and Vaunthompsonia cristata Bate, 1858 represents a new record for Puerto Rico from the mesophotic reefs.
Resonant Generation and Energetics of Wind-Forced Near-Inertial Motions in a Geostrophic Flow
Authors: Whitt Daniel B. , Thomas Leif N. 
Published: October 2014

AbstractA slab mixed layer model and two-dimensional numerical simulations are used to study the generation and energetics of near-inertial oscillations in a unidirectional, laterally sheared geostrophic current forced by oscillatory winds. The vertical vorticity of the current ζg modifies the effective Coriolis frequency , which is equivalent to the local resonant forcing frequency. In addition, the resonant oscillatory velocity response is elliptical, not circular, because the oscillation periodically exchanges energy with the geostrophic flow via shear production. With damping, this energy exchange becomes permanent, but its magnitude and sign depend strongly on the angle of the oscillatory wind vector relative to the geostrophic flow. However, for a current forced by an isotropic distribution of wind directions, the response averaged over all wind angles results in a net extraction of energy from the geostrophic flow that scales as the wind work on the inertial motions times (ζg/f)2 for ζg ≪ f. For ζg ~ f, this sink of geostrophic kinetic energy preferentially damps flows with anticyclonic vorticity and thus could contribute toward shaping the positively skewed vorticity distribution observed in the upper ocean.
EVI1-rearranged acute myeloid leukemias are characterized by distinct molecular alterations
Authors: Lavallée Vincent-Philippe , Gendron Patrick , Lemieux Sébastien , D’Angelo Giovanni , Hébert Josée , Sauvageau Guy 
Published: October 2014

Key Points
EVI1-r AMLs have recurrent mutations in RAS and other signaling genes, splicing factors, and at a lower frequency, IKZF1 and TP53. EVI1-r AMLs show a characteristic transcriptome profile marked by high expression of MECOM, PREX2, MYCT1, PAWR, and VIP.
High-sensitivity troponin T as a marker to predict cardiotoxicity in breast cancer patients with adjuvant trastuzumab therapy
Authors: Katsurada Kenichi , Ichida Masaru , Sakuragi Masako , Takehara Megumi , Hozumi Yasuo , Kario Kazuomi 
Published: October 2014

Abstract
The humanized monoclonal antibody trastuzumab has been in routine use for chemotherapy for human epidermal growth factor receptor II (HER2)-positive breast cancer. A major adverse effect of trastuzumab is cardiotoxicity. Well-established biomarkers or echocardiographic parameters to predict trastuzumab-induced cardiotoxicity have not yet been determined. We attempted to identify useful biomarkers and/or echocardiographic parameters to predict trastuzumab-induced cardiotoxicity.
We prospectively investigated the cases of 19 women who received chemotherapy including anthracyclines and trastuzumab for HER2-positive breast cancer. We measured cardiac biomarkers and echocardiographic parameters before their chemotherapy and every 3 months up to 15 months until the end of the adjuvant trastuzumab therapy.
We divided the patients into two groups: group R was the nine patients who showed a reduction of left ventricular ejection fraction (LVEF) ≥5%, and group N was the 10 patients who showed a reduction of LVEF <5%. The high-sensitivity troponin T (hs-TnT) level at 6 months was significantly higher in group R than in group N (11.0 ± 7.8 pg/mL vs. 4.0 ± 1.4 pg/mL, p < 0.01). The hs-TnT level with a cutoff value of 5.5 pg/mL at 6 months had 78% sensitivity and 80% specificity for predicting a reduction of LVEF at 15 months. In our evaluation of echocardiographic parameters at baseline, the diastolic function was more impaired in group R than in group N.
The hs-TnT and echocardiographic parameters of diastolic function could be useful to predict trastuzumab-induced cardiotoxicity.