bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suctioning habits in the delivery room and the influence on postnatal adaptation – a video analysis
Authors: Konstantelos Dimitrios , Ifflaender Sascha , Dinger Jürgen , Rüdiger Mario 
Published: November 2015

Abstract

Aims: To determine how often infants are suctioned during delivery and how it affects the neonate.

Methods: Single-center analysis of video-recorded delivery room management after c-section from January 2012 until April 2013. Time point, duration, and frequency of suctioning in term and preterm newborns were analyzed along with vital parameters (heart rate (HR) and saturation values).

Results: Three hundred forty-six videos were analyzed. Twenty-three percent of term and 66% of preterm newborns were suctioned. Newborns were suctioned up to 14 times; total duration spent for suctioning was between 2 and 154 s. Suctioning before face mask application occurred in 31% of the suctioned newborns requiring respiratory support. No severe bradycardia (<60 bpm) was noticed. Suctioning did not have an effect on HR and saturation in preterm infants but was associated with significantly higher HR in term infants requiring respiratory support. Term infants who did not require respiratory support showed significantly higher saturation values at 3, 5, 6, 7, 8, 9, and 10 min if they were not suctioned.

Conclusions: Suctioning of newborns in the delivery room does not adhere to recommendations of international guidelines. However, previously described side effects of suctioning could not be confirmed.
CuO/polypyrrole nanocomposites as a marker of toxic lead ions for ecological remediation in contrast with CuO and polypyrrole
Authors: Radhakrishnan Asha , Rejani Padmavathiamma , Beena Bhaskaran 
Published: November 2015

AbstractIn the present study, CuO, polypyrrole (PPy), and CuO/PPy nanocomposites were synthesized to compare the selective adsorption behavior of hazardous metal ions such as Pb(II) ions. The synthesized nanomaterials were characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy, Brunauer-Emmett-Teller surface area analysis, and energy dispersive X-ray spectroscopy. The adsorption studies clearly showed that CuO/PPy nanocomposites exhibited much higher adsorption performance than individual CuO and PPy. Kinetic data followed the pseudo-second-order model. The equilibrium attained at 120 min and isotherm follows the order Sips>Langmuir>Freundlich. The adsorbed Pb(II) is desorbed using 0.1
Immunity, inflammatory and psychophysiological stress response during a competition of professional rugby union
Authors: Lindsay Angus , Lewis John , Gill Nicholas , Gieseg Steven P. , Draper Nick 
Published: November 2015

AbstractNeopterin, cortisol and immunoglobulin A were measured to determine what effect a professional rugby competition has on the immunity, inflammatory and psychophysiological stress response. Urine and saliva were collected from 37 professional players at regular intervals throughout a 20 week professional competition. Total neopterin, cortisol and secretory immunoglobulin A were analysed using enzyme linked immunosorbant assay (ELISA) and high performance liquid chromatography (HPLC). All markers did not change significantly when analysed as a group during the course of the season compared to baseline (p>0.05), although long-distance travel had a minor effect on cortisol and secretory immunoglobulin A concentrations (p<0.05). More importantly, a large inter-individual variation for all markers was observed (p<0.001). These results indicate this competition of professional rugby does not cause significant changes in psychophysiological stress. Some players however, may become more susceptible to fatigue and infection during the course of a season as a result of suppressed immunity and sustained activation of the inflammatory response.
Accurate measurements of 129I concentration by isotope dilution using MC-ICPMS for half-life determination
Authors: Isnard Hélène , Nonell Anthony , Marie Mylène , Chartier Frédéric 
Published: November 2015

Abstract
Determining the 129I concentration, a long-lived radionuclide present in spent nuclear fuel, is a major issue for nuclear
waste disposal purpose. 129I also has to be measured in numerous environmental, nuclear and biological samples. To be able
to accurately determine the 129I concentration, an analytical method based on the use of a multicollector-inductively
coupled plasma mass spectrometer (MC-ICPMS) combined with an isotope dilution technique using an 127I spike, was
developed. First, the influence of different media (HNO3, NaOH and TMAH) on natural 127I signal
intensity and stability and on memory effects was studied. Then an analytical procedure was developed by taking into account the
correction of blanks and interferences. Tellurium was chosen for instrumental mass bias correction, as no certified standards with
suitable 127I/129I ratio are available. Finally, the results, reproducibility and uncertainties obtained for
the 129I concentration determined by isotope dilution with a 127I spike are presented and discussed. The final
expanded relative uncertainty obtained for the iodine-129 concentration was lower than
0.7% (k = 1). This precise 129I determination in association with further activity measurements of this nuclide on the
same sample will render it possible to determine a new value of the 129I half-life with a reduced uncertainty
(0.76%, k = 1).
AMPA Receptor Phosphorylation and Synaptic Colocalization on Motor Neurons Drive Maladaptive Plasticity below Complete Spinal Cord Injury
Authors: Huie J. Russell , Stuck Ellen D. , Lee Kuan H. , Irvine Karen-Amanda , Beattie Michael S. , Bresnahan Jacqueline C. , Grau James W. , Ferguson Adam R. 
Published: October 2015

AbstractClinical spinal cord injury (SCI) is accompanied by comorbid peripheral injury in 47% of patients. Human and animal modeling data have shown that painful peripheral injuries undermine long-term recovery of locomotion through unknown mechanisms. Peripheral nociceptive stimuli induce maladaptive synaptic plasticity in dorsal horn sensory systems through AMPA receptor (AMPAR) phosphorylation and trafficking to synapses. Here we test whether ventral horn motor neurons in rats demonstrate similar experience-dependent maladaptive plasticity below a complete SCIin vivo. Quantitative biochemistry demonstrated that intermittent nociceptive stimulation (INS) rapidly and selectively increases AMPAR subunit GluA1 serine 831 phosphorylation and localization to synapses in the injured spinal cord, while reducing synaptic GluA2. These changes predict motor dysfunction in the absence of cell death signaling, suggesting an opportunity for therapeutic reversal. Automated confocal time-course analysis of lumbar ventral horn motor neurons confirmed a time-dependent increase in synaptic GluA1 with concurrent decrease in synaptic GluA2. Optical fractionation of neuronal plasma membranes revealed GluA2 removal from extrasynaptic sites on motor neurons early after INS followed by removal from synapses 2 h later. As GluA2-lacking AMPARs are canonical calcium-permeable AMPARs (CP-AMPARs), their stimulus- and time-dependent insertion provides a therapeutic target for limiting calcium-dependent dynamic maladaptive plasticity after SCI. Confirming this, a selective CP-AMPAR antagonist protected against INS-induced maladaptive spinal plasticity, restoring adaptive motor responses on a sensorimotor spinal training task. These findings highlight the critical involvement of AMPARs in experience-dependent spinal cord plasticity after injury and provide a pharmacologically targetable synaptic mechanism by which early postinjury experience shapes motor plasticity.
Cell-Type Specific Channelopathies in the Prefrontal Cortex of thefmr1-/yMouse Model of Fragile X Syndrome
Authors: Kalmbach Brian E. , Johnston Daniel , Brager Darrin H. 
Published: November 2015

AbstractFragile X syndrome (FXS) is caused by transcriptional silencing of thefmr1gene resulting in the loss of fragile X mental retardation protein (FMRP) expression. FXS patients display several behavioral phenotypes associated with prefrontal cortex (PFC) dysfunction. Voltage-gated ion channels, some of which are regulated by FMRP, heavily influence PFC neuron function. Although there is evidence for brain region-specific alterations to the function a single type of ion channel in FXS, it is unclear whether subtypes of principal neurons within a brain region are affected uniformly. We tested for alterations to ion channels critical in regulating neural excitability in two subtypes of prefrontal L5 pyramidal neurons. Using somatic and dendritic patch-clamp recordings, we provide evidence that the functional expression of h-channels (Ih) is down-regulated, whereas A-type K+channel function is up-regulated in pyramidal tract-projecting (PT) neurons in thefmr1-/ymouse PFC. This is the opposite pattern of results from published findings from hippocampus whereIhis up-regulated and A-type K+channel function is down-regulated. Additionally, we find that somatic Kv1-mediated current is down-regulated, resulting in increased excitability offmr1-/yPT neurons. Importantly, these h- and K+channel differences do not extend to neighboring intratelencephalic-projecting neurons. Thus, the absence of FMRP has divergent effects on the function of individual types of ion channels not only between brain regions, but also variable effects across cell types within the same brain region. Given the importance of ion channels in regulating neural circuits, these results suggest cell-type-specific phenotypes for the disease.
THERAPY OF ENDOCRINE DISEASE: Testosterone supplementation and body composition: results from a meta-analysis study
Authors: Corona Giovanni , Giagulli Vito A , Maseroli Elisa , Vignozzi Linda , Aversa Antonio , Zitzmann Michael , Saad Farid , Mannucci Edoardo , Maggi Mario 
Published: November 2015

ObjectiveThe role of testosterone (T) in regulating body composition is conflicting. Thus, our goal is to meta-analyse the effects of T supplementation (TS) on body composition and metabolic outcomes.MethodsAll randomized controlled trials (RCTs) comparing the effect of TS on different endpoints were considered.ResultsOverall, 59 trials were included in the study enrolling 3029 and 2049 patients in TS and control groups respectively. TS was associated with any significant modification in body weight, waist circumference and BMI. Conversely, TS was associated with a significant reduction in fat and with an increase in lean mass as well as with a reduction of fasting glycaemia and insulin resistance. The effect on fasting glycaemia was even higher in younger individuals and in those with metabolic diseases. When only RCTs enrolling hypogonadal (total T <12 mol/l) subjects were considered, a reduction of total cholesterol as well as triglyceride (TGs) levels were also detected. Conversely, an improvement in HDL cholesterol levels as well as in both systolic and diastolic blood pressure was not observed.ConclusionOur data suggest that TS is able to improve body composition and glycometabolic profile particularly in younger subjects and in those with metabolic disturbances. Specifically designed studies are urgently needed to confirm this point.
Soft Drink Influence on Margin Integrity in Composite Resin Restorations
Authors: Lafuente Jose , Abad Karol 
Published: November 2015

<p><span>The purpose of this study was to evaluate the effect that certain previously selected soda drinks could have on the integrity of the margins of composite restorations made on 25 human teeth, where the margins were placed both on enamel and dentin. Specimens were divided in different groups (n=5) to be exposed to soft drinks 30 minutes a day for 30 days. Selected drinks were: Coca Cola, Coca Cola Zero, Squirt, Gladiator and water. SEM pictures were taken at the beginning and at the 30 day mark. Data were compared and analyzed using Kruskal-Wallis. Results showed changes in color both in enamel and in dentin, as well as pigmentation of the composite resin qith the use of Coca Cola and Coca Cola Zero. This last one had the biggest negative impact on the margins of the resotrations, both on enamel and dentin, though this canges were not statistically significant. All soft drinks produced some damage to the margins which went from a small change barely detectable, up to a complete loss of integrity, these effects were not statistically significant among drinks. </span></p>
Transnational Migration and Sociocultural practices : mapping the use of ICTs
Authors: Zanforlin Sofia Cavalcanti 
Published: October 2015

<p>The following paper intends to present the first results of the research Migration and Intercultural Communication : transnational flows, local interferences and the use of ICTs. One of the aims of this research is to study the transnational sociocultural practices through the use of information and communication technologies (ICTs) of the migrants in the Federal District of Brazil. This research is based on the following questions : can we qualify the recent migration flows to Brazil as a transnational phenomenon ? If yes, what is the role of the ICTs in the information exchange between migrants ? How do these technologies interfere and re-create sociocultural practices during the migrant's process of belonging ? We wish to understand how is it that ICTs make it possible for a twofold local experience : that of the daily life of those who stayed and that of the living experience of those who moved.</p>
Cigarette Smoking, Tooth Loss, and Chronic Obstructive Pulmonary Disease: Findings From the Behavioral Risk Factor Surveillance System
Authors: Cunningham Timothy J. , Eke Paul I. , Ford Earl S. , Agaku Israel T. , Wheaton Anne G. , Croft Janet B. 
Published: November 2015

Background: Cigarette smoking and tooth loss are seldom considered concurrently as determinants of chronic obstructive pulmonary disease (COPD). This study examines the multiplicative effect of self‐reported tooth loss and cigarette smoking on COPD among United States adults aged ≥18 years.Methods: Data were taken from the 2012 Behavioral Risk Factor Surveillance System (n = 439,637). Log‐linear regression–estimated prevalence ratios (PRs) are reported for the interaction of combinations of tooth loss (0, 1 to 5, 6 to 31, or all) and cigarettes smoking status (never, former, or current) with COPD after adjusting for age, sex, race/ethnicity, marital status, educational attainment, employment, health insurance coverage, dental care utilization, and diabetes.Results: Overall, 45.7% respondents reported having ≥1 teeth removed from tooth decay or gum disease, 18.9% reported being current cigarette smokers, and 6.3% reported having COPD. Smoking and tooth loss from tooth decay or gum disease were associated with an increased likelihood of COPD. Compared with never smokers with no teeth removed, all combinations of smoking status categories and tooth loss had a higher likelihood of COPD, with adjusted PRs ranging from 1.5 (never smoker with 1 to 5 teeth removed) to 6.5 (current smoker with all teeth removed) (all P <0.05).Conclusions: Tooth loss status significantly modifies the association between cigarette smoking and COPD. An increased understanding of causal mechanisms linking cigarette smoking, oral health, and COPD, particularly the role of tooth loss, infection, and subsequent inflammation, is essential to reduce the burden of COPD. Health providers should counsel their patients about cigarette smoking, preventive dental care, and COPD risk.
Antibacterial potentiality of antiulcer and antispasmodic drugs with selected antibiotics against methicillin resistant <i>Staphylococcus aureus</i>: <i>In vitro</i> and <i>in silico</i> studies
Authors: Akilandeswari Krishnan , Ruckmani Kandasamy 
Published: October 2015

<p class="Abstract">In the present study, the antispasmodic drug mebeverine hydrochloride and the antiulcer drug troxipide were tested for their possible antibacterial properties <em>in vitro</em>. The antimicrobial assays of the above drugs were determined with ampicillin, penicillin and ciprofloxacin against sensitive and resistant strains and their resistance were confirmed through Polymerase Chain Reaction by identifying the presence of the <em>mec</em>A gene. A computer-aided method was used for screening the effectiveness of the drug interactions. Mebeverine and troxipide inhibited most of the sensitive and resistant strains tested<em> in vitro</em> from 32.5 to 125 µg/mL. The loss of structural alterations of the cell wall was analyzed by atomic force microscopy. In docking studies, troxipide and mebeverine were found to have substantial inhibition against penicillin binding protein 2a (IVQQ) and UDP-N-acetylglucosamine 1-carboxyvinyltransferase (2YVW) receptor proteins that seem to have interacted with most of the residues.</p><p class="Abstract"> </p><p class="Abstract"><strong>Video Clips</strong></p><p class="Abstract"><a href="https://www.youtube.com/v/CpfdUxdNvt0">Set up</a> 2 min 27 sec</p><p class="Abstract"><a href="https://www.youtube.com/v/IJlkGtIViUU">Broth and drug</a> 4 min 40 sec</p><p class="Abstract"><a href="https://www.youtube.com/v/_jZHZ8zOJlc">Inoculation</a> 2 min 29 sec</p><p class="Abstract"><a href="https://www.youtube.com/v/VYT5slycgdE">Incubation and result</a> 46 sec</p><p> </p><p> </p><p align="center"><strong><br /></strong></p>
Vers une société du narcissisme pervers
Authors: Gadeau Ludovic 
Published: November 2015

L’accélération des changements propre à la postmodernité s’accompagne-t-elle de remaniements structuraux au niveau du fonctionnement psychologique (intra- et intersubjectif) et social dont on pourrait décrire certains éléments et définir certains liens ? Dans le champ de la psychopathologie et en psychothérapie, on constate depuis une vingtaine d’années une augmentation des problématiques narcissiques par rapport à des modes d’organisation névrotiques, ce qui ne saurait s’expliquer sans prise en compte de facteurs impliquant l’évolution sociétale. En prenant la temporalité comme angle de lecture, l’auteur soutient l’idée que l’accélération du changement (provoqué notamment par l’évolution technoscientifique), si elle s’accompagne de progrès améliorant potentiellement la condition humaine, produit dans le même temps une fragilisation des assises identitaires et narcissiques de l’homme, induite elle-même par un processus sous-jacent de désinstitutionalisation et de détemporalisation du temps. Cette déstructuration temporelle ouvre un espace au déploiement de mécanismes et de formes de fonctionnement au voisinage de la perversion, comme la déresponsabilité subjectale. Sont ainsi posées (et subsumées sous le terme de narcissisme pervers) certaines des caractéristiques du nouveau rapport au Temps et à la Loi.
Le virus du conspirationnisme
Authors: Soufron Jean-Baptiste 
Published: October 2015

Il faut comprendre l’émergence de la culture conspirationniste pour y répondre. Celle-ci obéit aux mêmes mécanismes qu’un virus : une fois activé, il se propage en cascade et finit par menacer la santé du corps social. Il importe donc de bien repérer les responsabilités des entrepreneurs du complot et de protéger leur public en améliorant nos institutions sociales de la connaissance.
Une approche psychodynamique des troubles spécifiques des apprentissages
Authors: Brun Anne , Guinard Frédérik 
Published: November 2015

La prise en charge des enfants présentant des troubles des apprentissages a bénéficié des dernières évolutions paradigmatiques de la psychanalyse dans l’accompagnement de patients en difficulté majeure avec la symbolisation. Ces mutations épistémologiques ont rendu possible le développement de nouveaux dispositifs de rencontre : les médiations thérapeutiques, permettant aux enfants en difficulté d’apprentissage d’explorer leur sensorialité en appui sur leur appareil de langage et rendant possible ainsi la transformation d’éprouvés infantiles non subjectivés. Au travers de la description d’une expérience de groupe peinture avec un préadolescent en difficulté d’apprentissage, ce travail met en évidence la manière dont les processus de réactualisation et de subjectivation qui s’engagent dans l’utilisation de l’objet de médiation ont des effets positifs sur les capacités de symbolisation mobilisées dans les apprentissages.
Adipose-Derived Mesenchymal Stem Cells Prevent Systemic Bone Loss in Collagen-Induced Arthritis
Authors: Garimella Manasa G. , Kour Supinder , Piprode Vikrant , Mittal Monika , Kumar Anil , Rani Lekha , Pote Satish T. , Mishra Gyan C. , Chattopadhyay Naibedya , Wani Mohan R. 
Published: November 2015

Abstract
Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic inflammatory synovitis leading to joint destruction and systemic bone loss. The inflammation-induced bone loss is mediated by increased osteoclast formation and function. Current antirheumatic therapies primarily target suppression of inflammatory cascade with limited or no success in controlling progression of bone destruction. Mesenchymal stem cells (MSCs) by virtue of their tissue repair and immunomodulatory properties have shown promising results in various autoimmune and degenerative diseases. However, the role of MSCs in prevention of bone destruction in RA is not yet understood. In this study, we investigated the effect of adipose-derived MSCs (ASCs) on in vitro formation of bone-resorbing osteoclasts and pathological bone loss in the mouse collagen-induced arthritis (CIA) model of RA. We observed that ASCs significantly inhibited receptor activator of NF-κB ligand (RANKL)–induced osteoclastogenesis in both a contact-dependent and -independent manner. Additionally, ASCs inhibited RANKL-induced osteoclastogenesis in the presence of proinflammatory cytokines such as TNF-α, IL-17, and IL-1β. Furthermore, treatment with ASCs at the onset of CIA significantly reduced clinical symptoms and joint pathology. Interestingly, ASCs protected periarticular and systemic bone loss in CIA mice by maintaining trabecular bone structure. We further observed that treatment with ASCs reduced osteoclast precursors in bone marrow, resulting in decreased osteoclastogenesis. Moreover, ASCs suppressed autoimmune T cell responses and increased the percentages of peripheral regulatory T and B cells. Thus, we provide strong evidence that ASCs ameliorate inflammation-induced systemic bone loss in CIA mice by reducing osteoclast precursors and promoting immune tolerance.
IL-21 Promotes Pulmonary Fibrosis through the Induction of Profibrotic CD8+ T Cells
Authors: Brodeur Tia Y. , Robidoux Tara E. , Weinstein Jason S. , Craft Joseph , Swain Susan L. , Marshak-Rothstein Ann 
Published: October 2015

Abstract
Type 2 effector production of IL-13, a demonstrated requirement in models of fibrosis, is routinely ascribed to CD4+ Th2 cells. We now demonstrate a major role for CD8+ T cells in a murine model of sterile lung injury. These pulmonary CD8+ T cells differentiate into IL-13–producing Tc2 cells and play a major role in a bleomycin-induced model of fibrosis. Differentiation of these Tc2 cells in the lung requires IL-21, and bleomycin treated IL-21– and IL-21R–deficient mice develop inflammation but not fibrosis. Moreover, IL-21R–expressing CD8+ cells are sufficient to reconstitute the fibrotic response in IL-21R–deficient mice. We further show that the combination of IL-4 and IL-21 skews naive CD8+ T cells to produce IL-21, which, in turn, acts in an autocrine manner to support robust IL-13 production. Our data reveal a novel pathway involved in the onset and regulation of pulmonary fibrosis and identify Tc2 cells as key mediators of fibrogenesis.