bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Broensted Acid‐Promoted Dimerization of o‐Alkynylbenzaldehydes: A One‐Step Synthesis of Functionalized Kagan′s Ether Analogues.
Authors: Zhang Hao , Cui Wei‐Chen , Hu Zho‐Long , Yu Shu‐Yan , Wang Shaozhong , Yao Zhu‐Jun 
Published: September 2012

AbstractDimerization of o‐alkynylbenzaldehydes towards Kagan′s ether analogues proceeds smoothly in the presence of aqueous HBF4 in acetic acid.
ChemInform Abstract: Copper‐Mediated Oxidative Cross‐Coupling Reaction of Terminal Alkynes with α‐Silyldifluoromethylphosphonates: An Efficient Method for α,α‐Difluoropropargylphosphonates.
Authors: Jiang Xueliang , Chu Lingling , Qing Feng‐Ling 
Published: September 2012

AbstractThe order of addition of reagents is crucial to achieve a high yield.
ChemInform Abstract: Microtermolides A (I) and B (II) from Termite‐Associated Streptomyces sp. and Structural Revision of Vinylamycin.
Authors: Carr Gavin , Poulsen Michael , Klassen Jonathan L. , Hou Yanpeng , Wyche Thomas P. , Bulgni Tim S. , Currie Cameron R. , Clardy Jon 
Published: September 2012

AbstractThe title compounds are isolated and characterized, but no absolute configuration is determined.
ChemInform Abstract: A New Cyclopeptide and Other Constituents from the Leaves of Zanthoxylum rigidum Humb. & Bonpl. ex. Willd. (Rutaceae).
Authors: Nascimento Ribeiro Tereza Auxiliadora , da Silva Leticia Ricette , de Sousa Jr. Paulo Teixeira , Castro Rosane Nora , De Carvalho Mario Geraldo 
Published: September 2012

AbstractThe new peptide is identified as cyclozanthoxylane A (I).
ChemInform Abstract: Constituents of Dalbergia sissoo Roxb. Leaves with Osteogenic Activity.
Authors: Dixit Preety , Chillara Raju , Khedgikar Vikram , Gautam Jyoti , Kushwaha Priyanka , Kumar Avinash , Singh Divya , Trivedi Ritu , Maurya Rakesh 
Published: September 2012

AbstractThe new isoflavone glucoside (I) and the new itaconic derivative (II) are isolated along with a series of known structurally related substances from the ethanolic extract of Indian Rosewood leaves.
ChemInform Abstract: Three New Phenol Compounds from Iris dichotoma Pall.
Authors: Huang Long , Ma Wenhui , Liu Yanze , Peng Yong , Xiao Peigen 
Published: September 2012

AbstractIrisdichototin D (I) (only relative configuration determined) is identified together with the epimeric carbohydrate analogues irisdichototin E (IIa) and F (IIb).
Hydrothermal Curing – A Solution for Increasing Resource Productivity by Fine‐Grained Mineral Construction Waste
Authors: Forberger Jens , Hartmann Andrea , Müller Anette , Woidasky Jörg 
Published: September 2012

AbstractBei der Aufbereitung von Bau‐ und Abbruchabfällen – dem größten Abfallstrom in Deutschland – wird derzeit nur 1 % des mineralischen Bauschutts in qualitativ hochwertigen Einsatzgebieten wie dem Hochbau eingesetzt. Ein Großteil wird einer minderwertigen Verwertung zugeführt. In einem Forschungsprojekt werden daher Möglichkeiten einer stofflich hochwertigen Verwertung des mineralischen Bauschutts, der mittels hydrothermaler Erhärtung zu Granulaten aufbereitet wurde, untersucht. Durch die hydrothermale Behandlung werden Festigkeiten erzielt, die einen Einsatz beispielsweise als (Leicht‐)Zuschlag für Beton oder als Schüttung ermöglichen. Der Beitrag zeigt Ergebnisse aus dem laufenden Forschungsprojekt.
Multivariate Kendall's tau for change‐point detection in copulas
Authors: Quessy Jean‐François , Saïd Mériem , Favre Anne‐Catherine 
Published: September 2012

AbstractStatistical procedures for the detection of a change in the dependence structure of a series of multivariate observations are studied in this work. The test statistics that are proposed are $L_1$, $L_2$, and $L_{\infty }$ distances computed from vectors of differences of Kendall's tau; two multivariate extensions of Kendall's measure of association are used. Since the distributions of these statistics under the null hypothesis of no change depend on the unknown underlying copula of the vectors, a procedure based on the multiplier central limit theorem is used for the computation of p‐values; the method is shown to be valid both asymptotically and for moderate sample sizes. Alternative versions of the tests that take into account possible breakpoints in the marginal distributions are also investigated. Monte Carlo simulations show that the tests are powerful under many scenarios of change‐point. In addition, two estimators of the time of change are proposed and their efficiency is carefully studied. The methodologies are illustrated on simulated series from the Canadian Regional Climate Model. The Canadian Journal of Statistics 41: 65–82; 2013 © 2012 Statistical Society of Canada
Consistency of maximum likelihood estimators in a large class of deconvolution models
Authors: Groeneboom Piet , Jongbloed Geurt , Michael Stefanie 
Published: September 2012

AbstractWe consider the maximum likelihood estimator$\hat{F}_n$of a distribution function in a class of deconvolution models where the known density of the noise variable is of bounded variation. This class of noise densities contains in particular bounded, decreasing densities. The estimator$\hat{F}_n$is defined, characterized in terms of Fenchel optimality conditions and computed. Under appropriate conditions, various consistency results for$\hat{F}_n$are derived, including uniform strong consistency.The Canadian Journal of Statistics41: 98–110; 2013 © 2012 Statistical Society of Canada
Detection of low level cryoglobulins by flow cytometry
Authors: Müller Rüdiger B. , Vogt Birgit , Winkler Silke , Muñoz Luis E. , Franz Sandra , Kern Peter , Maihöfner Christian , Sheriff Ahmed , von Kempis Johannes , Schett Georg , Herrmann Martin 
Published: September 2012

AbstractSeveral patients with cryoglobulin (CG) associated symptoms are seronegative for CG and other potentially causative biomarkers. We analyzed whether it is possible to detect cryoprecipitates by flow cytometry and whether the sensitivity of their demonstration can be increased as compared to visual inspection. Sera from 91 patients with suspected CG associated symptoms and 33 healthy controls were examined for the presence of CG by conventional visual testing and by flow cytometry for small diffracting particles. For calibration purposes we tested lipid micelle dilutions (positive controls) by both methods. The minimum concentrations of lipid micelles to be detected by visual inspection and flow cytometry were 128.5 and 2.0 pg ml−1, respectively. Among the 91 patients and 33 controls, only 1 patient serum was positive for CG by conventional testing. This sample was also positive on flow cytometry. In the serum of a patient known to be positive for CG, laser diffracting particles were quantified by flow cytometry after keeping serum at 4°C for 3 days. Of the 91 patients, 14 additional samples displayed cold precipitates which redissolved after rewarming during flow cytometry. All 15 (1 + 14) patients positive for CG on flow cytometry suffered from symptoms usually associated with CG. Some precipitates were labeled with anti IgG and IgM antibodies confirming that the particles detected by flow cytometry contained immunoglobulins. No small diffracting particles were detected in the sera of the 33 healthy controls. Flow cytometry is equally specific but much more sensitive in the detection of CG than visual inspection. © 2012 International Society for Advancement of Cytometry
Palladium‐Mediated Heck‐Type Reactions of [(Bromodifluoromethyl)sulfonyl]benzene: Synthesis of α‐Alkenyl‐ and α‐Heteroaryl‐Substituted α,α‐Difluoromethyl Phenyl Sulfones
Authors: Surapanich Nakin , Kuhakarn Chutima , Pohmakotr Manat , Reutrakul Vichai 
Published: September 2012

AbstractPalladium‐catalyzed Heck‐type reactions of [(bromodifluoromethyl)sulfonyl]benzene (1) with styrene derivatives and heteroaromatic compounds successfully gave α‐alkenyl‐ and α‐heteroaryl‐substituted α,α‐difluoromethyl phenyl sulfones, respectively.
Helical Atropisomers of Strained Phenanthrenes by Photochemistry of Aromatic Pauson–Khand Cycloadducts
Authors: Ji Yining , Khaizourane Héléa , Wein Alexander N. , Verdaguer Xavier , Riera Antoni 
Published: September 2012

AbstractNorbornene and norbornadiene Pauson–Khand adducts of bis(3,5‐dimethylphenyl)acetylene and bis(3,4,5‐trimethylphenyl)acetylene were prepared. These compounds were subjected to a photochemical 6π‐electrocyclic oxidative aromatization reaction to give the corresponding phenanthrene compounds in satisfactory yield in the case of norbornene derivatives. The helical twist imposed by the methyl groups at the 3‐ and 5‐positions on the aromatic rings led to two atropisomers as a result of the non‐planar helical phenanthrene structure. The molecular structures and conformational stabilities of these atropisomers were examined by X‐ray crystallography and variable temperature NMR studies.
Insight into the Regioselectivity of Nucleophilic Ring‐Opening of Azetidinium Ions Containing Quaternary Carbon Atoms
Authors: Drouillat Bruno , Wright Karen , David Olivier , Couty François 
Published: September 2012

AbstractA set of azetidinium ions each bearing a quaternary carbon atom α to the nitrogen atom were synthesized. These compounds were treated with three different nuclophiles: azide, cyanide and acetate anions. Examination of the regioselectivity in the ring‐opening reactions demonstrated that attack at the quaternary position is intrinsically favored over that at the secondary position. However, these SN2 reactions are highly sensitive to steric crowding, which can counterbalance the natural trend to react at the quaternary carbon.
Enantioselective Metalation of N,N‐Diisopropylferrocenecarboxamide and Methyl Ferrocenecarboxylate Using Lithium‐Metal Chiral Bases
Authors: Dayaker Gandrath , Tilly David , Chevallier Floris , Hilmersson Göran , Gros Philippe C. , Mongin Florence 
Published: September 2012

AbstractEnantioselective deprotonative metalations of substituted ferrocenes using mixed lithium‐metal bases are described. Using N,N‐diisopropylferrocenecarboxamide as substrate, magnesium, iron, cobalt, zinc, and cadmium were tested as metals in bis[(S)‐1‐phenylethyl]amido‐based combinations; after interception of the metalated species with iodine, very high enantiomeric excess (96 %) but low yield was obtained with cobalt, whereas zinc and cadmium only gave 27 and 30 % ee, respectively, but in excellent yields. The small alkyl groups methyl and ethyl were identified as particularly suitable in the reaction using the putative dialkyl bis[(S)‐1‐phenylethyl]amido‐based lithium and dilithium zincates. The dimethyl dilithium zincate was selected for a study of dependency on the temperature, reaction time, and amount of base. Increased enantioselectivities with temperature, reaction time, and amount of base were noted (ee = 86 % at 0 °C after 2 h, 2 equiv. of base). The best result using methyl ferrocenecarboxylate as substrate was observed without alkyl ligand.
Wearable Electrochemical Sensors and Biosensors: A Review
Authors: Windmiller Joshua Ray , Wang Joseph 
Published: September 2012

AbstractThis article reviews recent advances and developments in the field of wearable sensors with emphasis on a subclass of these devices that are able to perform highly‐sensitive electrochemical analysis. Recent insights into novel fabrication methodologies and electrochemical techniques have resulted in the demonstration of chemical sensors able to augment conventional physical measurements (i.e. heart rate, EEG, ECG, etc.), thereby providing added dimensions of rich, analytical information to the wearer in a timely manner. Wearable electrochemical sensors have been integrated onto both textile materials and directly on the epidermis for various monitoring applications owing to their unique ability to process chemical analytes in a non‐invasive and non‐obtrusive fashion. In this manner, multi‐analyte detection can easily be performed, in real time, in order to ascertain the overall physiological health of the wearer or to identify potential offenders in their environment. Of profound importance is the development of an understanding of the impact of mechanical strain on textile‐ and epidermal (tattoo)‐based sensors and their failure mechanisms as well as the compatibility of the substrate employed in the fabrication process. We conclude this review with a retrospective outlook of the field and identify potential implications of this new sensing paradigm in the healthcare, fitness, security, and environmental monitoring domains. With continued innovation and detailed attention to core challenges, it is expected that wearable electrochemical sensors will play a pivotal role in the emergent body sensor networks arena.
Optimum lateral load pattern for seismic design of elastic shear‐buildings incorporating soil–structure interaction effects
Authors: Ganjavi Behnoud , Hao Hong 
Published: September 2012

SUMMARYRecently, several new optimum loading patterns have been proposed by researchers for fixed‐base systems while their adequacy for soil–structure systems has not been evaluated yet. Through intensive dynamic analyses of multistory shear‐building models with soil–structure interaction subjected to a group of 21 artificial earthquakes adjusted to soft soil design spectrum, the adequacy of these optimum patterns is investigated. It is concluded that using these patterns the structures generally achieve near optimum performance in some range of periods. However, their efficiency reduces as soil flexibility increases especially when soil–structure interaction effects are significant. In the present paper, using the uniform distribution of damage over the height of structures, as the criterion, an optimization algorithm for seismic design of elastic soil–structure systems is developed. The effects of fundamental period, number of stories, earthquake excitation, soil flexibility, building aspect ratio, damping ratio and damping model on optimum distribution pattern are investigated. On the basis of 30,240 optimum load patterns derived from numerical simulations and nonlinear statistical regression analyses, a new lateral load pattern for elastic soil–structure systems is proposed. It is a function of the fundamental period of the structure, soil flexibility and structural slenderness ratio. It is shown that the seismic performance of such a structure is superior to those designed by code‐compliant or recently proposed patterns by researchers for fixed‐base structures. Using the proposed load pattern in this study, the designed structures experience up to 40% less structural weight as compared with the code‐compliant or optimum patterns developed based on fixed‐base structures. Copyright © 2012 John Wiley & Sons, Ltd.
A well‐balanced weighted essentially non‐oscillatory scheme for pollutant transport in shallow water
Authors: Li Gang , Gao Jinmei , Liang Qiuhua 
Published: September 2012

SUMMARYIn this paper, a well‐balanced finite difference weighted essentially non‐oscillatory scheme is presented for modeling transport and diffusion of pollutant in shallow water flows. The scheme balances exactly the flux gradients and the source terms. Extensive one‐dimensional and two‐dimensional numerical experiments on uniform and curvilinear meshes strongly suggest that high resolution results are achieved for both water depth and pollutant concentration. The scheme is efficient and robust and can be applied to practical numerical simulation of pollutant transport phenomena in shallow water flows. Copyright © 2012 John Wiley & Sons, Ltd.
An exact non‐linear Navier–Stokes compressible‐flow solution for CFD code verification
Authors: Iannelli Joe 
Published: September 2012

SUMMARYAn exact similarity solution of the compressible‐flow Navier–Stokes equations is presented, which embeds supersonic, transonic, and subsonic regions. Describing the viscous and heat‐conducting high‐gradient flow in a shock wave, the solution accommodates non‐linear temperature‐dependent viscosity as well as heat‐conduction coefficients and provides the variation of all the flow variables and their derivatives. Also presented are methods to obtain time‐dependent and/or multi‐dimensional solutions as well as verification benchmarks of increasing severity. Comparisons between the developed analytical solution and CFD solutions of the Navier–Stokes equations, with determination of convergence rates and orders of accuracy of these solutions, illustrate the utility of the developed exact solution for verification purposes. Copyright © 2012 John Wiley & Sons, Ltd.
Structural alterations in chronic lymphocytic leukaemia. Cytogenetic and FISH analysis
Authors: Travella Ana , Ripollés Lorena , Aventin Anna , Rodríguez Andrea , Bezares Raimundo F , Caballín María R , Slavutsky Irma 
Published: September 2012

AbstractIn this study, we described cytogenetics and fluorescence in situ hybridization (FISH) analysis performed in chronic lymphocytic leukaemia (CLL) patients with structural alterations. Results were correlated with clinical characteristics. A total of 38 CLL patients: 16 cases with complex and 22 with simple karyotypes were studied. For comparison of clinical parameters, a control group of 78 CLL patients with normal karyotype and without FISH genomic alterations were also evaluated. We found 38 structural abnormalities not previously described in the literature, 28 (74%) of them were translocations. In cases with complex karyotypes, chromosomes 6, 8 and 13 were the most frequently involved in new alterations (nine each), followed by chromosomes 12, 14 and 15 (six each). Chromosome 8p was particularly involved in losses, being 8p21‐pter the commonest region of overlap. Cases with simple karyotypes, showed del(6q) as the most frequent alteration (39%). Del(9)(q11) was recurrent in our series. Analysis of clinical parameters showed significant differences in white blood count (p = 0.005) and platelet count (p = 0.015) between patients with structural alterations and the control group. In addition, patients with structural alterations had a significantly shorter time to first treatment (TFT) (29 months) than the control group (69 months) (p = 0.037). Cases with complex karyotypes had a lower proportion of patients in Rai 0 clinical stage (15.4% vs 75%) (p = 0.005) and higher β2 microglobulin levels (3.3 vs 2.5 µg/mL) (p = 0.037) than those with simple karyotypes. Furthermore, a shorter TFT (13 months) and overall survival (56 months) in the complex karyotypes group compared with controls (69 and 144 months, respectively) (p = 0.015 and p = 0.005, respectively) were also found. Our results support the importance of cytogenetic analysis for clinical outcome in CLL and suggest that the diversity of genomic alterations is much greater than previously appreciated. Copyright © 2012 John Wiley & Sons, Ltd.
Re‐evaluation of prognostic markers including staging, serum free light chains or their ratio and serum lactate dehydrogenase in multiple myeloma patients receiving novel agents
Authors: Maltezas Dimitrios , Dimopoulos Meletios A. , Katodritou Irene , Repousis Panagiotis , Pouli Anastasia , Terpos Evangelos , Panayiotidis Panayiotis , Delimpasi Sossana , Michalis Evridiki , Anargyrou Konstantinos , Gavriatopoulou Maria , Stefanoudaki Aikaterini , Tzenou Tatiana , Koulieris Efstathios , Sachanas Sotiris , Dimou Maria , Vassilakopoulos Theodoros P. , Angelopoulou Maria K. , Pangalis Gerassimos A. , Kyrtsonis Marie‐Christine 
Published: September 2012

AbstractInternational Staging System (ISS), serum free light chain ratio (sFLCR) and lactate dehydrogenase (LDH) are well known, easily assessed independent prognostic indicators of outcome in multiple myeloma (MM). The purpose of the study was to re‐examine the prognostic contribution of these variables in a multicenter setting with special attention to MM patients treated with autologous stem cell transplantation (ASCT) or novel agents (NA). Three hundred and five symptomatic newly diagnosed MM patients were retrospectively studied. Twenty‐seven per cent, 32% and 41% were in ISS stages 1, 2, and 3, respectively. Fifty‐six per cent of them presented kappa light chain monoclonality; median sFLCR was 27.04 (0.37–1.9 × 105) and 47.97 (0.26–2.3 × 107) for kappa patients and lambda patients, respectively; patients with sFLCR above median constituted the high sFLCR group. Thirty‐one per cent of patients had increased LDH. As first line treatment, 55.7% received conventional treatment and 44.3% NA. After induction, 24% underwent ASCT, whereas 76% received NA at any line, either bortezomib (82.5%), thalidomide (48%) or lenalidomide (27%). When the 305 patients were analyzed together, staging, high sFLCR and abnormal LDH were predictive of survival. The same was true for patients that never received NA, whereas neither high sFLCR nor abnormal LDH constituted adverse factors in patients that received NA frontline. In the last group of patients, no difference was observed between ISS stages 2 and 3. The median 5‐year survival of patients that never received NA versus those who did frontline was 29% vs 47%, 7% vs 52% and 24% vs 40% in patients with abnormal LDH, high sFLCR and ISS stage 3, respectively (p = 0.03, p < 0.00001 and p = 0.035). In conclusion, patients gaining the most from NA are those with an aggressive disease as reflected by advanced stage, abnormal LDH and high sFLCR. In addition, the adverse impact of these three variables is obscured by NA. Copyright © 2012 John Wiley & Sons, Ltd.
Use of 137Cs and 210Pbex measurements on deposits in a karst depression to study the erosional response of a small karst catchment in Southwest China to land‐use change
Authors: Bai Xiaoyong , Zhang Xinbao , Long Yi , Liu Xiuming , Siyu Zhang 
Published: September 2012

AbstractKarst depressions represent important sinks for sediment, and such sediment can provide a valuable record of the impact of environmental change on soil erosion rates. However, the sediment dynamics of karst depressions are not well understood. This contribution reports a study of the small catchment of a karst depression in Southwest China, with a drainage area of 0.054 km2, aimed at using the sediment deposits in the depression to reconstruct the erosional response of the catchment to land‐use change and, more particularly, the deforestation which took place in 1979. 137Cs and 210Pbex are used as both chronometers and as tracers. Five cores, collected from the bottom of a depression, with an area of 2652 m2, showed similar 137Cs depth distributions, with a single 137Cs peak, which was attributed to the 1979 deforestation. The 137Cs activity associated with the peaks varied between 5.68 ± 0.64 and 9.19 ± 0.99 Bq kg–1. The average depth of sediment deposition between 1979 and 2008 deduced from the depths of the 1979 137Cs peak was 74.1 cm. The existence of relatively high 210Pbex activity of 66.33 ± 8.44 Bq kg–1 in the upper section (0–16 cm) of the core analyzed for 210Pbex suggests that recent sedimentation has been very limited. Net erosion rates on the hillslopes contributing runoff and sediment t to the depression were estimated to be 5258 t km–2 year–1 from 1979 to 1990 and 256 t km–2 year–1 from 1991 to 2008, respectively. The high sediment yield in the first period was associated with the severe soil erosion triggered by the 1979 deforestation, which resulted from the changes in land ownership immediately after the Cultural Revolution. Soil erosion has been very limited since 1990 because the thin soils had been totally removed from many parts of the karst slopes and the soils remaining on the other parts of the slopes have been protected by terracing or vegetation rehabilitation. Copyright © 2012 John Wiley & Sons, Ltd.