bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Polycyclic N‐Heterocyclic Compounds. Part 75. Synthesis of 2,4‐Disubstituted 5,6‐Dihydro[1]benzoxepino[5,4‐d]pyrimidines and 12‐Substituted 1,2,4,5‐Tetrahydro[1]benzoxepino[4,5‐e]imidazo[1,2‐c]pyrimidines as Potential Antiplatelet Aggregators.
Authors: Okuda Kensuke , Yamamoto Yuko , Hirota Takashi , Sasaki Kenji 
Published: January 2015

AbstractSeveral compound libraries are prepared including compounds (III) and other compounds derived from (III), e.
ChemInform Abstract: Synthesis of N‐Hydroxyalkyl‐1,5,3‐dithiazepanes Based on Amino Alcohols.
Authors: Rakhimova E. B. , Ismagilov R. A. , Meshcheryakova E. S. , Zainullin R. A. , Khalilov L. M. , Ibragimov A. G. , Dzhemilev U. M. 
Published: January 2015

AbstractTwo alternative methods for the synthesis of novel N‐hydroxyalkyldithiazepanes (III) by recyclization of 1‐oxa‐3,6‐dithiacycloheptane (I) with amino alcohols (II) or intermolecular cyclization of 1,2‐ethanedithiol with methoxymethylamino alcohols (V) are developed.
ChemInform Abstract: trans‐Diborylation of Alkynes: pseudo‐Intramolecular Strategy Utilizing a Propargylic Alcohol Unit.
Authors: Nagashima Yuki , Hirano Keiichi , Takita Ryo , Uchiyama Masanobu 
Published: January 2015

AbstractThe first trans‐selective diboration of alkynes is achieved using a pseudo‐intramolecular reaction of diboron with propargyl alcohols.
ChemInform Abstract: Diversity Oriented Synthesis of Conjugate Dienes and Alkenylcyclopropanes Utilizing Silyl Group‐Substituted Titanium Carbene Complexes as Bimetallic Synthetic Reagents.
Authors: Takeda Takeshi , Mori Ayako , Fujii Tomoya , Tsubouchi Akira 
Published: January 2015

AbstractThe silyl compounds prepared by this method undergo cross‐coupling reactions with retention of configuration.
ChemInform Abstract: Three New Pentacyclic Triterpenoids from Centella asiatica.
Authors: Shao Yan , Ou‐Yang Dan‐Wei , Gao Wen , Cheng Liang , Weng Xiao‐Xiang , Kong De‐Yun 
Published: January 2015

Abstractisolation and structure elucidation of new triterpenoids, centellasaponin I (I), J (II), and E (III)
ChemInform Abstract: Anthraquinone Derivatives and an Orsellinic Acid Ester from the Marine Alga‐Derived Endophytic Fungus Eurotium cristatum EN‐220.
Authors: Du Feng‐Yu , Li Xiao‐Ming , Song Ji‐Ying , Li Chun‐Shun , Wang Bin‐Gui 
Published: January 2015

AbstractThe anthraquinone glycoside (I), and the orsellinic ester, cristatumside A (II), are isolated along with three known aromatic glycosides as well as three known anthraquinone derivatives from the fungal strain Euroticum cristatum.
ChemInform Abstract: Three New Prenylated Diketopiperazines from Neosartorya fischeri.
Authors: Zheng Zhen‐Zhen , Shan Wei‐Guang , Wang Shi‐Lei , Ying You‐Min , Ma Lie‐Feng , Zhan Zha‐Jun 
Published: January 2015

AbstractNeofipiperazines A (Ia), B (Ib), and C (II) are isolated along with six known compounds from the culture of Neosartorya fischeri.
ChemInform Abstract: New Derivatives of Nonactic and Homononactic Acids from Bacillus pumilus Derived from Breynia fruticosa.
Authors: Han Li , Huo Peiyuan , Chen Huahong , Li Songtao , Jiang Yi , Li Liya , Xu Lihua , Jiang Chenglin , Huang Xueshi 
Published: January 2015

Abstractisolation, structure and cytotoxicity
ChemInform Abstract: A Domino Approach to the Enantioselective Total Syntheses of Blennolide C and Gonytolide C.
Authors: Tietze Lutz F. , Jackenkroll Stefan , Hierold Judith , Ma Ling , Waldecker Bernd 
Published: January 2015

AbstractKey to the syntheses of blennolide C (I) and gonytolide C (II), is an enantioselective domino‐Wacker/carbonylation/methoxylation reaction to set up the stereocenter at C‐4a.
ChemInform Abstract: First Stereoselective and Concise Synthesis of Rhoiptelol C.
Authors: Purushotham Sudina Purushotham , Chinnababu Baggu , Venkateswarlu Yenamandra 
Published: January 2015

AbstractThe diarylheptanoid rhoiptelol C (I) is stereoselectively obtained starting from readily available vanilin using Keck′s asymmetric allylation, olefin cross metathesis, and Sharpless asymmetric dihydroxylation reaction as key steps.
ChemInform Abstract: Green and Size‐Controllable Synthesis of Photoluminescent Carbon Nanoparticles from Waste Plastic Bags.
Authors: Hu Yaoping , Yang Jing , Tian Jiangwei , Jia Li , Yu Jun‐Sheng 
Published: January 2015

AbstractPhotoluminescent carbon nanoparticles (CNP) are prepared by size‐controllable hydrothermal treatment (autoclave, 180 °C, 12 h) of various waste plastic bags in highly diluted H2O2 solutions (≤5.0 wt%) involving oxidative degradation, carbonization, and passivation followed by dialysis (molecular weight cut‐off: 1,000 Da) and freeze‐drying of the obtained solution.
ChemInform Abstract: μSR and Inelastic Neutron Scattering Investigations of the Caged Type Kondo Semimetals: CeT2Al10 (T: Fe, Ru and Os)
Authors: Adroja D. T. , Hillier A. D. , Muro Y. , Takabatake T. , Strydom A. M. , Bhattacharyya A. , Daoud‐Aladin A. , Taylor J. W. 
Published: January 2015

AbstractReview: 222 refs.
ChemInform Abstract: Recent Developments in the Chemistry of Pyridyl‐Functionalized, Low‐Coordinate Phosphorus Heterocycles
Authors: Mueller Christian , Sklorz Julian A. W. , de Krom Iris , Loibl Antonia , Habicht Marija , Bruce Marlene , Pfeifer Gregor , Wiecko Jelena 
Published: January 2015

AbstractReview: [53 refs.
The prognosis of MYC translocation positive diffuse large B‐cell lymphoma depends on the second hit
Authors: Clipson Alexandra , Barrans Sharon , Zeng Naiyan , Crouch Simon , Grigoropoulos Nicholas F , Liu Hongxiang , Kocialkowski Sylvia , Wang Ming , Huang Yuanxue , Worrillow Lisa , Goodlad John , Buxton Jenny , Neat Michael , Fields Paul , Wilkins Bridget , Grant John W , Wright Penny , EI‐Daly Hesham , Follows George A , Roman Eve , Watkins A James , Johnson Peter W M , Jack Andrew , Du Ming‐Qing 
Published: January 2015

AbstractA proportion of MYC translocation positive diffuse large B‐cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double‐hit DLBCL, and are clinically aggressive. It is unknown whether there are other genetic abnormalities that cooperate with MYC translocation and form double‐hit DLBCL, and whether there is a difference in clinical outcome between the double‐hit DLBCL and those with an isolated MYC translocation. We investigated TP53 gene mutations along with BCL2 and BCL6 translocations in a total of 234 cases of DLBCL, including 81 with MYC translocation. TP53 mutations were investigated by PCR and sequencing, while BCL2 and BCL6 translocation was studied by interphase fluorescence in situ hybridization. The majority of MYC translocation positive DLBCLs (60/81 = 74%) had at least one additional genetic hit. In MYC translocation positive DLBCL treated by R‐CHOP (n = 67), TP53 mutation and BCL2, but not BCL6 translocation had an adverse effect on patient overall survival. In comparison with DLBCL with an isolated MYC translocation, cases with MYC/TP53 double‐hits had the worst overall survival, followed by those with MYC/BCL2 double‐hits. In MYC translocation negative DLBCL treated by R‐CHOP (n = 101), TP53 mutation, BCL2 and BCL6 translocation had no impact on patient survival. The prognosis of MYC translocation positive DLBCL critically depends on the second hit, with TP53 mutations and BCL2 translocation contributing to an adverse prognosis. It is pivotal to investigate both TP53 mutations and BCL2 translocations in MYC translocation positive DLBCL, and to distinguish double‐hit DLBCLs from those with an isolated MYC translocation.
Radical Polymer Containing a Polytriphenylamine Backbone: Its Synthesis and Electrochemical Performance as the Cathode of Lithium‐Ion Batteries
Authors: Su Chang , Yang Fang , Xu Lihuang , Zhu Xiaogang , He Huihui , Zhang Cheng 
Published: January 2015

AbstractA novel radical monomer containing triphenylamine and the 2,2,6,6‐tetramethylpiperidinyl‐N‐oxy (TEMPO) radical has been synthesized. The corresponding linear homopolymer of 4‐carboxy‐N,N‐diphenylaniline‐2,2,6,6‐tetramethylpiperidin‐1‐yloxy (PTPA‐TEMPO) was then prepared by chemical oxidative polymerization. The chemical structure and electrochemical properties of the prepared polymers were characterized by Fourier transform infrared spectroscopy, ultraviolet–visible spectroscopy, scanning electron microscopy, cyclic voltammetry, and galvanostatic charge–discharge testing by the simulated lithium‐ion half‐cell method. The results demonstrated that the as‐synthesized functional polymers exhibited an initial discharge capacity of up to 140 mAh g−1 with two well‐defined plateaus at the potential of 3.8 and 2.7 V versus Li/Li+. Furthermore, the PTPA‐TEMPO electrode showed superior cycling and rate performances. The improved electrochemical performances were attributed to the construction of the novel linear radical molecular structure with PTPA as the conductive polymer backbone, which improved the long‐range charge‐carrier transportation and facilitated the Li+‐ion insertion–extraction process in the aggregated polymer bulk during the charge–discharge process.
Performance Improvement for Dye‐sensitized Solar Cells with Cone‐calix[4]arene Based Dyes
Authors: Tan Li‐Lin , Liu Jun‐Min , Li Shao‐Yong , Xiao Li‐Min , Kuang Dai‐Bin , Su Cheng‐Yong 
Published: January 2015

AbstractInvited for the cover of this issue is the group of Jun‐Min Liu and Cheng‐Yong Su at Sun Yat‐Sen University. The image shows that cone‐calix[4]arene‐based dye flowers can develop in the field of dye‐sensitized solar cells as sunflowers thrive under sunshine. The Full Paper itself is available at 10.1002/cssc.201402401
Mechanism of Brønsted Acid‐Catalyzed Glucose Dehydration
Authors: Yang Liu , Tsilomelekis George , Caratzoulas Stavros , Vlachos Dionisios G. 
Published: January 2015

AbstractWe present the first DFT‐based microkinetic model for the Brønsted acid‐catalyzed conversion of glucose to 5‐hydroxylmethylfurfural (HMF), levulinic acid (LA), and formic acid (FA) and perform kinetic and isotopic tracing NMR spectroscopy mainly at low conversions. We reveal that glucose dehydrates through a cyclic path. Our modeling results are in excellent agreement with kinetic data and indicate that the rate‐limiting step is the first dehydration of protonated glucose and that the majority of glucose is consumed through the HMF intermediate. We introduce a combination of 1) automatic mechanism generation with isotopic tracing experiments and 2) elementary reaction flux analysis of important paths with NMR spectroscopy and kinetic experiments to assess mechanisms. We find that the excess formic acid, which appears at high temperatures and glucose conversions, originates from retro‐aldol chemistry that involves the C6 carbon atom of glucose.
Simulation of bright‐field microscopy images depicting pap‐smear specimen
Authors: Malm Patrik , Brun Anders , Bengtsson Ewert 
Published: January 2015

AbstractAs digital imaging is becoming a fundamental part of medical and biomedical research, the demand for computer‐based evaluation using advanced image analysis is becoming an integral part of many research projects. A common problem when developing new image analysis algorithms is the need of large datasets with ground truth on which the algorithms can be tested and optimized. Generating such datasets is often tedious and introduces subjectivity and interindividual and intraindividual variations. An alternative to manually created ground‐truth data is to generate synthetic images where the ground truth is known. The challenge then is to make the images sufficiently similar to the real ones to be useful in algorithm development. One of the first and most widely studied medical image analysis tasks is to automate screening for cervical cancer through Pap‐smear analysis. As part of an effort to develop a new generation cervical cancer screening system, we have developed a framework for the creation of realistic synthetic bright‐field microscopy images that can be used for algorithm development and benchmarking. The resulting framework has been assessed through a visual evaluation by experts with extensive experience of Pap‐smear images. The results show that images produced using our described methods are realistic enough to be mistaken for real microscopy images. The developed simulation framework is very flexible and can be modified to mimic many other types of bright‐field microscopy images. © 2015 The Authors. Published by Wiley Periodicals, Inc. on behalf of ISAC
FlowSOM: Using self‐organizing maps for visualization and interpretation of cytometry data
Authors: Van Gassen Sofie , Callebaut Britt , Van Helden Mary J. , Lambrecht Bart N. , Demeester Piet , Dhaene Tom , Saeys Yvan 
Published: January 2015

AbstractThe number of markers measured in both flow and mass cytometry keeps increasing steadily. Although this provides a wealth of information, it becomes infeasible to analyze these datasets manually. When using 2D scatter plots, the number of possible plots increases exponentially with the number of markers and therefore, relevant information that is present in the data might be missed. In this article, we introduce a new visualization technique, called FlowSOM, which analyzes Flow or mass cytometry data using a Self‐Organizing Map. Using a two‐level clustering and star charts, our algorithm helps to obtain a clear overview of how all markers are behaving on all cells, and to detect subsets that might be missed otherwise. R code is available at https://github.com/SofieVG/FlowSOM and will be made available at Bioconductor. © 2015 International Society for Advancement of Cytometry
Preparation, Characterization, and Thermal Transformation of Poorly Crystalline Sodium‐ and Carbonate‐Substituted Calcium Phosphate
Authors: Strutynska Nataliia , Zatovsky Igor , Slobodyanik Nikolai , Malyshenko Anna , Prylutskyy Yuriy , Prymak Oleg , Vorona Igor , Ishchenko Stanislav , Baran Nikolai , Byeda Alexander , Mischanchuk Alexander 
Published: January 2015

AbstractIn this paper, we propose a new approach for the preparation of sodium‐ and carbonate‐substituted apatite by a wet precipitation method in aqueous media at 23 °C. The main difference between this method and conventional techniques is that poorly crystalline calcium phosphates are obtained and then heated to form crystalline apatite. The thermal transformations of the samples in the temperature range 80–1000 °C have been determined by temperature‐programmed desorption mass spectroscopy and thermogravimetry. The chemical and phase compositions of the sodium‐ and carbonate‐substituted apatite have been studied by inductively coupled plasma (ICP) atomic emission spectroscopy or atomic absorption spectroscopy and X‐ray diffraction, respectively. The degree and nature of the carbonate substitution have been determined by CHN analysis and IR spectroscopy, respectively. The samples were subjected to γ irradiation, and the formed radicals were studied by electron paramagnetic resonance (EPR) spectroscopy. SEM has shown nanoparticles (6–12 nm in diameter) with a stability to aggregation under heating to 500–550 °C (increase in size by 30–50 %).
Tattoo‐Based Wearable Electrochemical Devices: A Review
Authors: Bandodkar Amay J. , Jia Wenzhao , Wang Joseph 
Published: January 2015

AbstractThis article provides an overview of the recent advances in the field of skin‐worn tattoo‐based wearable electrochemical devices, including electrolyte and metabolite sensors, biofuel cells and batteries. Temporary tattoos are attractive platforms for fabricating skin‐worn devices. Body‐compliant wearable electrochemical devices on temporary tattoos couple highly favorable substrate‐skin elasticity with an attractive electrochemical performance. For example, tattoo‐based “skin‐like” sensors can be used for real‐time non‐invasive analysis of key electrolytes and metabolites, leading to remarkable sensing capabilities. Continued progress has been made also towards developing skin‐worn flexible energy harvesting and storage devices to power wearable health monitors and other devices. Key requirements and challenges that confront researchers in this exciting area of skin‐worn electrochemical devices are discussed.
Effects of 17β-estradiol on emissions of greenhouse gases in simulative natural water body
Authors: Ruan Aidong , Zhao Ying , Liu Chenxiao , Zong Fengjiao , Yu Zhongbo 
Published: January 2015

Abstract

Environmental estrogens are widely spread across the world and are increasingly thought of as serious contaminators. The present study looks at the influence of different concentrations of 17β-estradiol on greenhouse gas emissions (CO2, CH4, and N2O) in simulated systems to explore the relationship between environmental estrogen-pollution and greenhouse gas emissions in natural water bodies. The present study finds that 17β-estradiol pollution in simulated systems has significant promoting effects on the emissions of CH4 and CO2, although no significant effects on N2O emissions. The present study indicates that 17β-estradiol has different effects on the different elements cycles; the mechanism of microbial ecology is under review. Environ Toxicol Chem 2015;34:977–982. © 2015 SETAC
Features of acute liver congestion on gadoxetate disodium‐enhanced MRI in a rat model: Role of organic anion‐transporting polypeptide 1A1
Authors: Shimizu Akira , Kobayashi Akira , Motoyama Hiroaki , Sakai Hiroshi , Yamada Akira , Yoshizawa Akihiko , Momose Masanobu , Kadoya Masumi , Miyagawa Shin‐ichi 
Published: January 2015

PurposeTo evaluate the features of hepatic congestion on gadoxetate disodium (Gd‐EOB‐DTPA)‐enhanced magnetic resonance imaging (MRI) and the mechanisms responsible for the radiological findings in a rat model of partial liver congestion.Materials and MethodsA conventional T1‐weighted spin‐echo sequence of the liver was performed using a 1.5T magnetic resonance imager with an 80‐mm magnetic aperture for animal studies. We induced regional congestion using partial left lateral hepatic vein ligation (n = 5) and evaluated the following in both congestive liver (CL) and noncongestive liver (non‐CL): 1) chronological changes in the relative enhancement (RE) up to 60 minutes after Gd‐EOB‐DTPA administration, and 2) mRNA and protein expression of rat organic anion transporting protein 1a1 (Oatp1a1).ResultsThe RE in the CL reached a small peak (18%) at 5 minutes, corresponding to approximately half of the value observed in the non‐CL, then slowly decreased in a linear manner thereafter. The degree of RE in the CL was significantly lower than that in the non‐CL for up to 30 minutes (P < 0.05). An immunohistological examination showed that Oatp1a1 protein expression was downregulated in the CL. The mRNA level of Oatp1a1 in the CL was significantly upregulated, compared with that in control rat liver (P = 0.046), whereas no significant difference was observed between the CL and the non‐CL (P = 0.698).ConclusionThe reduced signal intensity in the CL on Gd‐EOB‐DTPA‐enhanced MRI could be explained by the decreased uptake of Gd‐EOB‐DTPA via Oatp1a1 protein in the congestive area. J. Magn. Reson. Imaging 2015;42:828–836.
White‐tailed deer population dynamics and adult female survival in the presence of a novel predator
Authors: Chitwood Michael C. , Lashley Marcus A. , Kilgo John C. , Moorman Christopher E. , Deperno Christopher S. 
Published: January 2015

ABSTRACTRecent localized declines in white‐tailed deer (Odocoileus virginianus) populations in the southeastern United States have been linked to increasing predation pressure from coyotes (Canis latrans), a novel predator to the region. Studies have documented coyotes as the leading cause of mortality for neonates, and 1 study documented coyotes as a mortality factor for adult females. However, no study has used field‐based vital rates to conduct sensitivity analyses or model deer population trajectories under potential harvest or predator removal strategies. We used low, medium, and high values of fawn survival, adult female survival, and fecundity data collected from Fort Bragg Military Installation, North Carolina to demonstrate the current declining population trajectory for deer (λ = 0.905; low λ = 0.788, high λ = 1.003). Consistent with other studies of ungulates, we determined adult female survival was the most sensitive and elastic vital rate. Further, for 3 potential management (“what if”) scenarios, we projected the population for 10 years using estimated vital rates. Reducing adult female harvest (λ = 0.935; low λ = 0.875, high λ = 1.002) and coyote removal (λ = 0.995; low λ = 0.898, high λ = 1.081) reduced the current population decline, whereas combining both approaches (λ = 1.024; low λ = 0.898, high λ = 1.141) resulted in population increases. Our data indicate that for low‐density deer populations with heavy predation pressure on neonates, protecting adult females from harvest may not completely offset population declines. Coyote removal might be a necessary strategy because it could possibly increase very low fawn survival, which appears to be the most important vital rate influencing λ in our study. However, managers may have to start with reductions in adult female harvest because coyote removal would have to be continuous and consistently effective, making it an impractical management approach by itself. © 2015 The Wildlife Society.
Predictive QSPR Modelling for the Second Virial Coefficient of the Pure Organic Compounds
Authors: Mokshyna E. , Polishchuk P. G. , Nedostup V. I. , Kuzmin V. E. 
Published: January 2015

AbstractIn this article we developed a system of the predictive models for the second virial coefficients of the pure compounds. Second virial coefficient is the property derived from the virial equation of state, and is of particular interest as it describes pair intermolecular interactions. The two‐layer QSPR models were developed, which exploited the well‐known physical equations and allowed us to include this information into traditional QSPR methodology. This shows some new perspectives for work with temperature‐dependent properties. It was shown that 2D descriptors can be successfully used for modeling of complex thermodynamic properties like virial coefficients.
Analysis of rectangular piles subjected to lateral loads in nonhomogeneous soil using a Winkler model approach
Authors: Hirai Hiroyoshi 
Published: January 2015

SummaryAn analytical approach using a Winkler model based on two lateral soil displacement components in a three‐dimensional soil is investigated to provide analytical solutions of horizontal response of a rectangular pile subjected to lateral loads in nonhomogeneous soil. The two lateral displacement components of a soil surrounding the rectangular pile are represented by the Fourier series of displacement potential functions in the elastic three‐dimensional analysis. The lateral stiffness coefficient of the rectangular pile shaft in nonhomogeneous soil is derived from the rocking stiffness coefficient taking into account rocking rotation of a rigid pile shaft. The relationship between horizontal displacement, rotation, moment, and shear force for the rectangular pile subjected to horizontal loads in nonhomogeneous soil is obtainable in the form of the recurrence equation. The formulation of lateral displacement and rotation for a rectangular pile subjected to lateral loads on the pile base in nonhomogeneous soil is proposed by taking into account Mindlin's equation and the equivalent thickness for soil layers in the equivalent elastic method. The difference of lateral behavior between square and circular piles subjected to lateral loads is insignificant. The effect of aspect ratio of the rectangular pile on the lateral behavior is great for the lower stiffness ratio between pile and soil and the larger length–equivalent diameter ratio. The effect of the value of Poisson's ratio of soil on lateral stiffness coefficient is relatively small except Poisson's ratio close to 0.5. The comparison of the results calculated by the current method for a rectangular pile subjected to lateral loads in nonhomogeneous soil has shown good agreement with those obtained from the analytical methods and the finite element method. Copyright © 2015 John Wiley & Sons, Ltd.