bluuebunny/crossref_metadata_2025_split huggingface dataset:
Efficacy of Interval Training in Improving Body Composition and Adiposity in Apparently Healthy Adults: An Umbrella Review with Meta-Analysis
Authors: Poon Eric Tsz-Chun , Li Hong-Yat , Little Jonathan Peter , Wong Stephen Heung-Sang , Ho Robin Sze-Tak 
Published: July 2024

Abstract
Background
Although the efficacy of interval training for improving body composition has been summarized in an increasing number of systematic reviews in recent years, discrepancies in review findings and conclusions have been observed.

Objective
This study aims to synthesize the available evidence on the efficacy of interval training compared with moderate-intensity continuous training (MICT) and nonexercise control (CON) in reducing body adiposity in apparently healthy adults.

Methods
An umbrella review with meta-analysis was performed. A systematic search was conducted in seven databases (MEDLINE, EMBASE, Cochrane Database, CINAHL, Scopus, SPORTDiscus, and Web of Science) up to October 2023. Systematic reviews with meta-analyses of randomized controlled trials (RCTs) comparing interval training and MICT/CON were included. Literature selection, data extraction, and methodological quality assessment (AMSTAR-2) were conducted independently by two reviewers. Meta-analyses were performed using a random-effects model. Subgroup analyses were conducted based on the type of interval training [high-intensity interval training (HIIT) and sprint interval training (SIT)], intervention duration, body mass index, exercise modality, and volume of HIIT protocols.

Results
Sixteen systematic reviews, including 79 RCTs and 2474 unique participants, met the inclusion criteria. Most systematic reviews had a critically low (n = 6) or low (n = 6) AMSTAR-2 score. Interval training demonstrated significantly greater reductions in total body fat percent (BF%) compared with MICT [weighted mean difference (WMD) of − 0.77%; 95% confidence interval (CI) − 1.12 to − 0.32%] and CON (WMD of − 1.50%; 95% CI − 2.40 to − 0.58%). Significant reductions in fat mass, visceral adipose tissue, subcutaneous abdominal fat, and android abdominal fat were also observed following interval training compared to CON. Subgroup analyses indicated that both HIIT and SIT resulted in superior BF% loss than MICT. These benefits appeared to be more prominent in individuals with overweight/obesity and longer duration interventions (≥ 12 weeks), as well as in protocols using cycling as a modality and low-volume HIIT (i.e., < 15 min of high-intensity exercise per session).

Conclusions
This novel umbrella review with large-scale meta-analysis provides an updated synthesis of evidence with implications for physical activity guideline recommendations. The findings support interval training as a viable exercise strategy for reducing adiposity in the general population.
Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults
Authors: Li Yaqin , Huang Yuting , Wei Fangxin , Li Tanjian , Wang Yu 
Published: July 2024

Abstract
Objective
The objective of this study was to develop a risk prediction model for motoric cognitive risk syndrome (MCR) in older adults.

Methods
Participants were selected from the 2015 China Health and Retirement Longitudinal Study database and randomly assigned to the training group and the validation group, with proportions of 70% and 30%, respectively. LASSO regression analysis was used to screen the predictors. Then, identified predictors were included in multivariate logistic regression analysis and used to construct model nomogram. The performance of the model was evaluated by area under the receiver operating characteristic (ROC) curve (AUC), calibration curves and decision curve analysis (DCA).

Results
528 out of 3962 participants (13.3%) developed MCR. Multivariate logistic regression analysis showed that weakness, chronic pain, limb dysfunction score, visual acuity score and Five-Times-Sit-To-Stand test were predictors of MCR in older adults. Using these factors, a nomogram model was constructed. The AUC values for the training and validation sets of the predictive model were 0.735 (95% CI = 0.708–0.763) and 0.745 (95% CI = 0.705–0.785), respectively.

Conclusion
The nomogram constructed in this study is a useful tool for assessing the risk of MCR in older adults, which can help clinicians identify individuals at high risk.
Impact of Covid-19 on the Economic Growth of ASEAN Countries: Convergence or Divergence?
Authors: D’Aloia Federico , Gugler Philippe 
Published: July 2024

AbstractThis contribution addresses the question of whether economic growth among ASEAN member countries is converging or diverging within the context of the COVID-19 pandemic. ASEAN has significantly developed economic and social mechanisms aimed at achieving greater integration among member countries, with the goal of enhancing economic growth and especially accelerating the catch-up of the poorer member countries. How resilient have the member countries been? Has the COVID-19 pandemic more severely affected the poorer member countries? To answer these questions, our contribution addresses this issue based on economic growth theories, particularly drawing on Solow’s theory regarding beta and gamma convergence. The study covers the period from 2000 to 2022. In the pre-pandemic period from 2000 to 2019, there is a general phenomenon of absolute convergence, demonstrating a reduction in the disparity in absolute values between less advanced and more modern countries, which also leads to a reduction in inequality as shown by the confirmation of the σ-convergence hypothesis. This is true for both GDPC and GDPW variables. The catch-up effect of absolute β-convergence is not evident when looking at the period from 2020 to 2022. During this timeframe, both the absolute β-convergence and σ-convergence hypotheses are rejected, which slows down the economic growth of poorer economies relative to the more advanced ASEAN countries. Overall, the entire 2000–2022 period confirms the unconditional β-convergence and σ-convergence assumptions of the pre-pandemic period.
Tectonic, Topographic, Geologic, and Hydroclimatic Influence on Crack Formation During the 2021 Haiti Earthquake
Authors: Saint Fleur Newdeskarl , Dessable Joseph E. , Saint‐Preux Germain , Calais Éric , Feuillet Nathalie , Boisson Dominique , de Chabalier Jean‐Bernard , Klinger Yann 
Published: July 2024

AbstractThe 14 August 2021 Haiti earthquake mainly portrayed reverse motion to the east near L’Asile town and left‐lateral strike‐slip motion to the west near Camp‐Perrin town. To map the rupture and infer its segmentation, we conducted the first post‐seismic field reconnaissance along the left‐lateral strike‐slip Enriquillo fault from L’Asile to Macaya mountain. We identified 98 linear, minor cracks that are not representative of primary fault surface rupture. Analyzing the topographic slope distribution, we detected that the cracks were often located in areas that are prone to topographic instability. About 60% of the cracks are located in Quaternary alluvium and Middle‐Miocene continental marls, indicating a preference for soft sediments. The rivers also have an impact, as crack lengths and openings negatively correlate with their distance to neighboring rivers. In addition, the earthquake occurred in a rainy region with up to 2,479.34 mm of rainfall in 2021, increasing soil instability. Above all, we found a contrast and asymmetry between the eastern and the western parts of the rupture. By dividing the 60‐km long rupture into two equal parts, we observed 57 cracks to the west against 41 to the east. The longest and the widest cracks are to the west. Analyzing their orientation, the cracks mainly oriented as left‐lateral strike‐slip faults to the west and mainly thrusts to the east. This configuration appears to be influenced by the slip pattern of the 2021 Haiti earthquake and consistent with the regional stress field.
An Attempt to Take Into Account Natural Variability in 1D Bedload Prediction
Authors: Recking A. , Johannot A. , Horita K. , Nasr M. , Vázquez‐Tarrío D. , Zanker S. , Fontaine F. , Melun G. 
Published: July 2024

AbstractBedload transport can fluctuate considerably over relatively short periods of time and for a given quasi‐constant flow rate. What are the implications of replacing the fluctuating signal with a smoothed signal when calculating bedload transport using averaged values, as is common practice? This question was investigated with the BedloadR code, which allows 1D bedload calculation as well as Monte Carlo simulations using a new data set collected in the Severaisse River (French Ecrins massif). Four bedload equations (Camenen & Larson, 2005, https://doi.org/10.1016/j.ecss.2004.10.019; Meyer‐Peter & Mueller, 1948; Parker, 1990, https://doi.org/10.1080/00221689009499058; Recking, 2013a, https://doi.org/10.1061/(asce)hy.1943‐7900.0000653) were selected for their performance relative to the measured bedload (except for and Meyer‐Peter and Mueller) and because each equation has a different mathematical form and degree of nonlinearity. They were used in a Monte Carlo approach, with input probability distributions fitted to the measured river width, slope, bed grain‐size distribution, and to the associated (computed) Shields stress. The results show that accounting for natural variability in the calculation reproduces bedload fluctuations well. But overall, when calculating the bedload volume transported by a flow event, accounting for variability systematically leads to higher estimated volumes (of the order of 20%) than those obtained with a deterministic approach using average input parameters. This is a direct consequence of the nonlinearity of the equations.
Investigation of the Contribution of Five Broadcast Ionospheric Models (GPSK, NTCMG, NEQG, BDGIM, and BDSK) and IRTG to GNSS Positioning During Different Solar Activities in Solar Cycle 25
Authors: Li Min , Yuan Yunbin , Zhang Ting , Xu Hanying , Huo Xingliang , Zhang Wenyao 
Published: July 2024

AbstractAdditional ionospheric information is essential for mitigating errors in single‐frequency (SF) Global Navigation Satellite Systems (GNSS) positioning. The increasing number of low‐cost dual‐frequency (DF) receiver users faces limitations in tracking DF observables compared to traditional geodetic receivers. Consequently, ionospheric correction algorithms (ICAs) are also essential for low‐cost DF devices in hybrid‐frequency positioning. To evaluate the performance of commonly used ICAs during solar cycle 25, our study presents a global statistical investigation of the contribution of five broadcast ionospheric models (BIMs) and the International GNSS Service (IGS) combined real‐time global ionospheric maps (IRTG) to the positioning domain, covering both quiet and perturbed ionospheric conditions. The BIMs investigated include the GPS Klobuchar (GPSK), Galileo NequickG (NEQG), NTCM‐GlAzpar (NTCMG), BDS‐2 Klobuchar (BDSK), and BeiDou Global Ionospheric delay correction Model (BDGIM). Experimental results from standard point positioning indicate that IRTG demonstrates superior overall accuracy compared to all BIMs, with a mean 3D root mean squared (RMS) of 2.76 m during perturbed period. Specifically, GPSK, NTCMG, NEQG, BDGIM, and BDSK exhibit RMS values of 2.03, 1.67, 1.72, 1.62, and 2.36 m during quiet conditions, and 4.02, 3.17, 2.86, 3.14, and 4.44 m during perturbed conditions, respectively. Among the BIMs, NEQG demonstrates superior performance at middle and high latitudes but exhibits lower accuracy than NTCMG and BDGIM at low latitudes during daytime under quiet conditions. BDGIM performs slightly better than NTCMG at low latitudes but slightly worse at high latitudes. BDSK shows notable improvement for high‐ and mid‐latitude regions since 3 June 2020.
Paleomagnetism of the Peloritan Terrane (NE Sicily): From Greater Iberia to the Neo Apennine‐Maghrebide Arc
Authors: Siravo Gaia , Speranza Fabio 
Published: July 2024

AbstractCalabria and the Peloritan Mts. of NE Sicily are exotic terranes predominantly formed by Hercynian rocks interrupting the Meso‐Cenozoic sediments exposed along Apennine‐Maghrebide chains. Dual‐polarity pre‐tilting magnetization direction retrieved from 5 Jurassic, 5 upper Cretaceous‐Eocene, and 4 upper Oligocene sedimentary sites from external‐intermediate Peloritan nappes yield 99° ± 12°, 131° ± 15°, and 138° ± 12° (respectively) clockwise (CW) rotations with respect to Europe. Upper Cretaceous‐Oligocene values are similar to the ∼130° CW late Miocene‐Early Pleistocene rotation previously documented on internal Maghrebian nappes of W Sicily. Jurassic data imply a ∼30° Early Cretaceous counterclockwise (CCW) rotation, similar for sign, magnitude, and timing to Iberia rotation, proving that the Peloritan crust was part of Greater Iberia before its <30 Ma fragmentation and dispersal. Furthermore, 20 Jurassic‐Oligocene sites yield post‐tilting overprint direction (later rotated up to 60° CW) that was acquired synchronous to late Miocene‐Pleistocene rotation. The Peloritan rotation is completely different from the 160° post‐late Jurassic CCW rotation documented on NE Calabria, and demonstrates that the two terranes underwent independent drift histories. Lack of a Sardinian rotation fingerprint (90° CCW between 30 and 15 Ma) suggests that the Peloritan terrane lied S of the Calabria‐Sardinia CCW rotating system, at the non‐rotational apex of an Oligocene‐early Miocene “Paleo Apennine‐Maghrebide Arc.” The Peloritan terrane was stacked onto the African margin and incorporated in the Maghrebian chain in mid Burdigalian (18–17 Ma). Afterward, it formed the S limb of the “Neo Apennine‐Maghrebide Arc,” and was passively carried on top of CW rotating Maghrebide nappes during late Miocene‐Early Pleistocene (12–1 Ma).
A Numerical Study of Tropical Cyclone and Ocean Responses to Air‐Sea Momentum Flux at High Winds
Authors: Zhao Biao , Wu Lichuan , Wang Guansuo , Zhang Jun A. , Liu Li , Zhao Chang , Zhuang Zhanpeng , Xia Changshui , Xue Yuhuan , Li Xinfang , Qiao Fangli 
Published: July 2024

AbstractThe relationship between minimum sea level pressure (MSLP) and maximum wind speed, is a commonly employed metric for assessing tropical cyclone (TC) forecast skill. However, accurately reproducing this relationship in TC forecasts is challenging. By introducing a new air‐sea momentum flux scheme considering both wave state and saturation (decrease) effect at high winds into a fully coupled atmosphere‐ocean‐wave model, our numerical results reveal that the maximum wind speed and MSLP respond oppositely to the air‐sea momentum flux change. The simulated wind‐pressure relationship aligns well with observations when the new flux scheme is used. This study highlights the large sensitivity of wind‐pressure relationship to the air‐sea momentum flux parameterization at high winds. Furthermore, the air‐sea momentum flux has a significant effect on ocean wave characteristics and sea surface temperature (SST) cooling in TC simulations.
Identifying early symptoms associated with a diagnosis of childhood, adolescent and young adult cancers: a population-based nested case-control study
Authors: Saatci D. , Oke J. , Harnden A. , Hippisley-Cox J. 
Published: July 2024

Abstract
Background
Childhood, teenage and young adult (CTYA, 0–24 years) cancers are rare and diverse, making timely diagnosis challenging. We aim to explore symptoms and symptom combinations associated with a subsequent cancer diagnosis and to establish their timeframe.

Methods
Using the QResearch Database, we carried out a matched nested case-control study. Associations between pre-specified symptoms encountered in primary care and a subsequent diagnosis of any cancer were explored using conditional logistic regression. Median diagnostic intervals were used to split symptoms into “late” and “early” timeframes to identify relevant early symptoms.

Results
3186 cases and 50,576 controls were identified from a cohort of 3,424,771 CTYA. We identified 12 novel associations, of which hemiparesis [OR 90.9 (95%CI 24.7-335.1), PPV = 1.6%], testicular swelling [OR 186.7 (95%CI 86.1-404.8), PPV = 2.4%] and organomegaly [OR 221.6 (95%CI 28.3-1735.9), PPV = 5.4%] had significant positive predictive values (PPV). Limb pain, a known marker of serious illness in children, was a recurrent early symptom across cancer subtypes. Similar clinical presentations were observed across childhood and TYA cancers.

Discussion
Using the largest cohort to date, we provide novel information on the time-varying predictive utility of symptoms in the diagnosis of CTYA cancers. Our findings will help to raise clinical and public awareness of symptoms, stratify those at higher-risk and ultimately aid earlier diagnosis.
The ubiquitin-like protein UBTD1 promotes colorectal cancer progression by stabilizing c-Myc to upregulate glycolysis
Authors: Zhao Liqin , Yu Nuoya , Zhai Yujia , Yang Yanan , Wang Yixuan , Yang Yue , Gong Zhe , Zhang Yanqiu , Zhang Xiaowei , Guo Weijian 
Published: July 2024

AbstractDysfunction of the ubiquitin-proteasome system (UPS) is involved in the pathogenesis of various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, regulates UPS-mediated protein degradation and tumor progression in some cancer types. However, the biological function and mechanism of UBTD1 are far from being well elucidated, and its role in CRC has not been explored yet. In our study, we analyzed CRC patients’ clinical information and UBTD1 expression data, and found that the expression of UBTD1 in cancer tissue was significantly higher than that in adjacent normal tissue. Higher UBTD1 expression was significantly associated with poorer survival and more lymph node metastasis. Overexpression of UBTD1 could facilitate, while knockdown could inhibit CRC cell proliferation and migration, respectively. RNA-seq and proteomics indicated that c-Myc is an important downstream target of UBTD1. Metabolomics showed the products of the glycolysis pathway were significantly increased in UBTD1 overexpression cells. In vitro, we verified UBTD1 upregulating c-Myc protein and promoting CRC cell proliferation and migration via regulating c-Myc. UBTD1 promoted CRC cells’ glycolysis, evidenced by the increased lactate production and glucose uptake following UBTD1 overexpression. Mechanistically, UBTD1 prolonged the half-life of the c-Myc protein by binding to E3 ligase β-transducin repeat-containing protein (β-TrCP), thereby upregulated the expression of glycolysis rate-limiting enzyme hexokinase II (HK2), and enhanced glycolysis and promoted CRC progression. In conclusion, our study revealed that UBTD1 promotes CRC progression by upregulating glycolysis via the β-TrCP/c-Myc/HK2 pathway, suggesting its potential as a prognostic biomarker and therapeutic target in CRC.
Preclinical and clinical advances to overcome hypoxia in glioblastoma multiforme
Authors: Bou-Gharios Jolie , Noël Georges , Burckel Hélène 
Published: July 2024

AbstractGlioblastoma multiforme (GBM) is the most common adult primary brain tumor. The standard clinical treatment of GBM includes a maximal surgical resection followed by concomitant radiotherapy (RT) and chemotherapy sessions with Temozolomide (TMZ) in addition to adjuvant TMZ cycles. Despite the severity of this protocol, GBM is highly resistant and recurs in almost all cases while the protocol remains unchanged since 2005. Limited-diffusion or chronic hypoxia has been identified as one of the major key players driving this aggressive phenotype. The presence of hypoxia within the tumor bulk contributes to the activation of hypoxia signaling pathway mediated by the hypoxia-inducing factors (HIFs), which in turn activate biological mechanisms to ensure the adaptation and survival of GBM under limited oxygen and nutrient supply. Activated downstream pathways are involved in maintaining stem cell-like phenotype, inducing mesenchymal shift, invasion, and migration, altering the cellular and oxygen metabolism, and increasing angiogenesis, autophagy, and immunosuppression. Therefore, in this review will discuss the recent preclinical and clinical approaches that aim at targeting tumor hypoxia to enhance the response of GBM to conventional therapies along with their results and limitations upon clinical translation.
Engineering for a clear image: a comparative focus on accommodation
Authors: Williams David 
Published: July 2024

AbstractThe eye requires the ability to focus images near and far and throughout evolution numerous mechanisms have developed to allow this accommodation. From primitive organisms which use a small pupil to effect pinhole camera optics without a lens through more complex eyes with a lens that is moved antero-posteriorly along the visual axis or the shape of which is changed, the eye has engineered numerous accommodative mechanisms. Human inventors have developed cameras with remarkable accommodative abilities but none match the remarkable focussing abilities of the four-eyed fish Anableps or the cormorant which similarly manages to focus above and below water, to give just two examples from the animal kingdom, perfectly adapted to their environments and behaviours.
Demethylation C–C coupling reaction facilitated by the repulsive Coulomb force between two cations
Authors: Zhang Xiaoping , Huang Keke , Fu Yanlin , Zhang Ni , Kong Xianglei , Cheng Yuanyuan , Zheng Mingyu , Cheng Yihao , Zhu Tenggao , Fu Bina , Feng Shouhua , Chen Huanwen 
Published: July 2024

AbstractCarbon chain elongation (CCE) is normally carried out using either chemical catalysts or bioenzymes. Herein we demonstrate a catalyst-free approach to promote demethylation C–C coupling reactions for advanced CCE constructed with functional groups under ambient conditions. Accelerated by the electric field, two organic cations containing a methyl group (e.g., ketones, acids, and aldehydes) approach each other with such proximity that the energy of the repulsive Coulomb interaction between these two cations exceeds the bond energy of the methyl group. This results in the elimination of a methyl cation and the coupling of the residual carbonyl carbon groups. As confirmed by high-resolution mass spectrometry and isotope-labeling experiments, the C–C coupling reactions (yields up to 76.5%) were commonly observed in the gas phase or liquid phase, for which the mechanism was further studied using molecular dynamics simulations and stationary-point calculations, revealing deep insights and perspectives of chemistry.
Potential of artificial intelligence in reducing energy and carbon emissions of commercial buildings at scale
Authors: Ding Chao , Ke Jing , Levine Mark , Zhou Nan 
Published: July 2024

AbstractArtificial intelligence has emerged as a technology to enhance productivity and improve life quality. However, its role in building energy efficiency and carbon emission reduction has not been systematically studied. This study evaluated artificial intelligence’s potential in the building sector, focusing on medium office buildings in the United States. A methodology was developed to assess and quantify potential emissions reductions. Key areas identified were equipment, occupancy influence, control and operation, and design and construction. Six scenarios were used to estimate energy and emissions savings across representative climate zones. Here we show that artificial intelligence could reduce cost premiums, enhancing high energy efficiency and net zero building penetration. Adopting artificial intelligence could reduce energy consumption and carbon emissions by approximately 8% to 19% in 2050. Combining with energy policy and low-carbon power generation could approximately reduce energy consumption by 40% and carbon emissions by 90% compared to business-as-usual scenarios in 2050.