bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tramadol inhibits the contractility of isolated human myometrium
Authors: Shah N. H. , Thomas E. , Jose R. , Peedicayil J. 
Published: February 2013

Summary

This study was conducted to determine whether the atypical opioid analgesic tramadol inhibits the contractility of isolated non‐pregnant human myometrium. Ten strips of non‐pregnant human myometrium stimulated with 55 mm potassium chloride (KCl) were treated with three concentrations (30, 100 and 300 μm) of tramadol to test for any inhibitory effect of tramadol. The effects of concurrent administration of the ß adrenoceptor antagonist propranolol (1 μm), the guanylyl cyclase and nitric oxide synthase inhibitor methylene blue (20 μm) and the opioid receptor antagonist naloxone (100 μm) with tramadol were also studied.
Tramadol caused a concentration‐dependent inhibition of KCl‐induced myometrial contractility, which was statistically significant at all three concentrations of tramadol used. Propranolol significantly reversed the inhibitory effect of 100 μm tramadol on KCl‐induced myometrial contractility but not that of 300 μm tramadol. Neither methylene blue nor naloxone reversed the inhibitory effect of tramadol on KCl‐induced myometrial contractility.
These results suggest that tramadol inhibits KCl‐induced contractility of isolated human myometrium. They also suggest that tramadol relaxes the myometrium due to stimulation of ß1 adrenoceptors. However, the concentrations of tramadol required to relax the myometrium were high and likely to be attained at toxic doses, rather than therapeutic doses, of tramadol.
Evolving Friendships and Shifting Ethical Dilemmas: Fieldworkers’ Experiences in a Short Term Community Based Study in Kenya
Authors: Kamuya Dorcas M. , Theobald Sally J. , Munywoki Patrick K. , Koech Dorothy , Geissler Wenzel P. , Molyneux Sassy C. 
Published: February 2013

AbstractFieldworkers (FWs) are community members employed by research teams to support access to participants, address language barriers, and advise on culturally appropriate research conduct. The critical role that FWs play in studies, and the range of practical and ethical dilemmas associated with their involvement, is increasingly recognised. In this paper, we draw on qualitative observation and interview data collected alongside a six month basic science study which involved a team of FWs regularly visiting 47 participating households in their homes. The qualitative study documented how relationships between field workers and research participants were initiated, developed and evolved over the course of the study, the shifting dilemmas FWs faced and how they handled them. Even in this one case study, we see how the complex and evolving relationships between fieldworkers and study participants had important implications for consent processes, access to benefits and mutual understanding and trust. While the precise issues that FWs face are likely to depend on the type of research and the context in which that research is being conducted, we argue that appropriate support for field workers is a key requirement to strengthen ethical research practice and for the long term sustainability of research programmes.
Optimal Contracting Model in a Social Environment and Trust-Related Psychological Costs
Authors: Basov Suren , Bhatti M. Ishaq 
Published: February 2013

AbstractMost research in contract theory concentrated on the role of incentives in shaping individual behavior. Recent research suggests that social norms also play an important role. From a point of view of a mechanism designer (a principal, a government, and a bank), responsiveness of an agent to the social norms is both a blessing and a curse. On the one hand, it provides the designer with extra instruments, while on the other it puts restrictions on how these new and the more conventional instruments can be used. The main objective of this paper is to investigate this trade-off and study how it shapes different contracts observed in the real world. We consider a model in which agent’s cost of cheating is triggered by the principal’s show of trust. We call such behavior a norm of honesty and trust and show that it drives incentives to be either low powerful or high powerful, eliminating contracts with medium powerful incentives.
Revised distribution and plant communities of Orobanche alsatica and notes on the Orobanchaceae series Alsaticae in Poland
Authors: Piwowarczyk Renata 
Published: February 2013

Abstract
The paper presents the current distribution of Orobanche alsatica in Poland, based on a critical revision of her­barium and literature data and on my field studies conducted in 2006-2011. The recorded localities are mainly in Polish Uplands: the Lublin Upland (Wyżyna Lubelska), Roztocze, and Polesie, less frequently in the Małopolska Upland (Wyżyna Małopolska) and Silesia-Kraków Upland (Wyżyna Śląsko-Krakowska). Distribution maps of O. alsatica and other species of the series Alsaticae (O. bartlingii and O. mayeri) in Poland are included. Their taxonomy, biology, ecology, and habitat pref­erences are also discussed.
Transversal Pressure Effect in Circulative Separators
Authors: Sawicki Jerzy M. 
Published: February 2013

Abstract
Progressive urban development of the human environment requires new methods of rain water treatment. Recently, there has been a growing interest in the improvement of gravitational suspension separation, and especially in the application of the centrifugal force. This important factor can be induced in two ways; by the circulation of the reservoir containing the fluid (centrifugal separators), or by a tangent supply of this reservoir (circulative separators). In addition to the centrifugal force, another essential transversal force is at work in this case, resulting from the local variability of the pressure. In the literature, this force is derived for centrifuge conditions, but applied also to circulative separators, which is questionable, as in the latter devices velocity and pressure fields are clearly different. The paper is devoted to the determination of the transversal pressure effect in circulative separators. First, a model of tangent and radial velocity profiles is introduced. The radial pressure distribution, calculated on this basis and verified experimentally, leads to the final result, that is, a technical formula describing the force in question
Comparison of Laparoscopic-Assisted and Open Colopexy in Dogs
Authors: Zhang Shixia , Zhang Jiantao , Zhang Nan , Shi Jiao , Wang Hongbin 
Published: February 2013

Abstract
The objective of this study was to describe laparoscopic-assisted colopexy (LAC) technique, and compare the extent of the surgical trauma after LAC and open colopexy (OC) by examing postoperative serum values of C-reactive protein (CRP) in dogs. Twelve healthy mixed-breed dogs with body weight ranging from 15 to 25 kg were used. Two portal sites were used for LAC procedures. OC was performed by laparotomy on linea alba. Colopexy was accomplished in all dogs without major intraoperative and postoperative complications. A permanent adhesion between the colon and abdominal wall was observed. There were statistically significant differences in serum CRP levels between LAC and OC immediately after the procedure and 1 d post operation. LAC had a similar pexy effect to OC, but had fewer surgical trauma than OC in dogs.
Mycoplasma Mycoides Subsp. Mycoides Small Colony Variant and Mycoplasma Agalactiae Antibodies in Ruminants in Poland
Authors: Dudek Katarzyna , Bednarek Dariusz , Szacawa Ewelina 
Published: February 2013

Abstract
The aim of the study was to determine Mycoplasma mycoides subsp. mycoides small colony variant (MmmSC) and Mycoplasma agalactiae antibodies in ruminants from different provinces/regions of Poland. Eight hundred and ten bovine serum samples were examined for MmmSC antibodies by the use of competitive ELISA (c-ELISA) and complement fixation test (CFT). ELISA was also used for M. agalactiae antibody detection in 951 serum samples of sheep and goats. The first screening serological examination of MmmSC antibodies using c-ELISA revealed two (0.25%) positive and 135 (16.92%) doubtful results. The second examination revealed only 52 doubtful results, whereas the rest samples were negative. To compare, the final confirmatory examination by CFT gave 100% of seronegative results. The examination performed in small ruminants demonstrated only one doubtful result, which was finally defined as negative following the second ELISA, whereas the remaining samples were negative. To conclude, the present serological study showed the lack of infections in Polish domestic ruminant caused by two mycoplasmas.
Natural Occurrence of Thiouracil in Urine of Livestock in Poland
Authors: Woźniak Barbara , Witek Sebastian , Żmudzki Jan , Kłopot Alicja 
Published: February 2013

Abstract
Natural occurrence of thiouracil in bovine and swine urine in Poland was investigated. Under the national residue control programme, 537 urine samples were tested. In 77 samples (14.3%) thiouracil was detected above decision limit CCα (0.91 μg L-1), including eight samples over the recommended concentration of 10 μg L-1. Of the bovine urine samples, 95 and 99 percentiles have thiouracil concentration below 4.50 and 14.85 μg L-1 ,and of porcine samples below 2.35 and 6.80 μg L-1, respectively.
Hideko Kamino and the eponym linked to her name / Hideko Kamino i eponim vezan za njeno ime
Authors: Al Abou Khalid 
Published: February 2013

Abstract
In 1979, Kamino and colleagues described pink globules, in the epidermis of Spitz nevi. These globules, later known as Kamino bodies, were PAS-positive, diastase-resistant, and positive on trichrome staining. Their presence does not rule out malignant melanoma completely, but makes it less likely, since similar globules were noted in the epidermis in only 2% of malignant melanomas and 0.9% of ordinary melanocytic nevi. The globules in malignant melanomas and ordinary melanocytic nevi were negative with PAS and trichrome staining. In 2010, Dr. HidekoKamino, received the Walter R. Nickel Award for Excellence in the Teaching of Dermatopathology. This short communication is about Professor Kamino and the dermatopathological condition that bears her name.
Selection of the open pit mining cut-off grade strategy under price uncertainty using a risk based multi-criteria ranking system / Wybór strategii określania warunku opłacalności wydobycia w kopalniach odkrywkowych w warunkach niepewności cen w oparciu o wielokryterialny system rankingowy z uwzględnieniem czynników ryzyka
Authors: Azimi Yousue , Osanloo Montza , Esfahanipour Akbar 
Published: February 2013

Abstract
Cut-off Grade Strategy (COGS) is a concept that directly influences the financial, technical, economic, environmental, and legal issues in relation to exploitation of a mineral resource. A decision making system is proposed to select the best technically feasible COGS under price uncertainty. In the proposed system both the conventional discounted cash flow and modern simulation based real option valuations are used to evaluate the alternative strategies. Then the conventional expected value criterion and a multiple criteria ranking system were used to rank the strategies based on the two valuation methods. In the multiple criteria ranking system besides the expected value other stochastic orders expressing abilities of strategies in producing extra profits, minimizing losses and achieving the predefined goals of the exploitation strategy are considered. Finally, the best strategy is selected based on the overall average rank of strategies through all ranking systems. The proposed system was examined using the data of Sungun Copper Mine. To assess the merits of the alternatives better, ranking process was done at both high (prevailing economic condition) and low price conditions. Ranking results revealed that at different price conditions and valuation methods, different results would be obtained. It is concluded that these differences are due to the different behavior of the embedded option to close the mine early, which is more likely to be exercised under low price condition rather than high price condition. The proposed system would enhance the quality of decision making process by providing a more informative and certain platform for project evaluation.
Endoscopic colloid cyst resection by puncture of the medial wall of lateral ventricle, posterior to the foramen of Monro
Authors: Păunescu D. , Gorgan M. , Tătăranu Ligia 
Published: February 2013

Abstract
No consensus among neurosurgeons has been reached so far concerning optimal therapeutic strategy for colloids cysts, especially as these are non-invasive,slowgrowing, benign lesions. In symptomatic cases, endoscopic resection can be achieved as first intention when it seems to have a cyst containing fluid and there is ventriculomegaly. Cyst location and degree of superior distension of the third ventricle roof, associated with the emergence of Monro’s foramen can cause problems when using a rigid endoscope, the visualisation being impossible or difficult. Posterior interventricular foramen puncture may be helpful in such cases.
Transformation of UML class diagram to internal java domain-specific language
Authors: Buzdin Dmitry , Nikiforova Oksana 
Published: February 2013

Abstract -
the article addresses the existing problems found in the area of Domain-Specific Languages (DSLs). Being a widely adopted programming technique, DSL grammar creation process still lacks desirable traceability and automation. The paper proposes a sequential model transformation process based on Model-Driven Architecture concepts as one of the potential solutions to stated problem. One of the main results of the research work is the implementation of prototype of the full-cycle model transformation chain starting from the UML domainmodel and ending with internal Java-based DSL grammar implementation.
Deconstructing the academic narrative: Applying a determinants of health framework to identify the drivers of research on wood bison (Bison bison athabascae)
Authors: Wilcox Alana , Sine Sarah , Morrill André , Stephen Craig , Provencher Jennifer F. 
Published: February 2025

Abstract

Conservation approaches that address complex and dynamic environmental challenges necessitate the dismantling of rigid academic boundaries and building effective interdisciplinary collaborations. The dominance of select disciplinary fields and/or interactions among diverse groups of researchers establishes the research narrative, ultimately guiding academic discussions and lending to conservation initiatives.

We applied a determinants of health (DOH) framework to examine how research narratives have approached the health of wood bison (Bison bison athabascae), a species with at‐risk herds facing imminent threats to recovery, and how the potential for clustered narratives creates challenges for a comprehensive view of bison health. We conducted a literature review, coding for whether articles qualitatively or quantitatively analysed wood bison health, or provided contextual information, classifying articles into six distinct DOH.

We found that articles principally analysed intrinsic and extrinsic biological factors related to wood bison health, but results were often contextualized in relation to the human expectations related to management, recovery and conservation of wood bison herds. We then examined author and institutional collaborations and timelines for publications of articles on wood bison health. We found that authors published research in multiple years, but authors with a high degree of collaborations were most often affiliated with academic, Canadian federal government or Canadian territorial government institutions. We show that wood bison health considers physical, social and human expectations related at individual wood bison and population levels.

Practical implications. Our results also suggest that there are few mechanisms to integrate information across disciplines, which could cause problems for a comprehensive assessment of wood bison health. Nonetheless, interdisciplinary frameworks, such as One Health, that examine the intersection of animal–environment–human health present potential ways forward for the conservation of wood bison.
Anion Chemistry in Regulating Water Structure for Aqueous Supercapacitors Operating at −60 °C
Authors: Liu Yingbin , Yu Chang , Lan Shuqin , Liu Weizhe , Qiu Jieshan 
Published: February 2025

AbstractAqueous electrolytes featuring intrinsic safety and high ionic conductivity have been envisioned as a competitive and promising electrolyte candidate for application in supercapacitors, but water solidification poses limitations on achieving stable low‐temperature operation of aqueous supercapacitors. Herein, an anion chemistry strategy is proposed and developed to modify water structures to formulate temperature‐adaptability aqueous electrolytes for low‐temperature supercapacitors. Multiple characterization techniques reveal a fundamental correlation between various anions and alteration of water structure. It is noteworthy that ClO4− with weak hydration can act as a high‐efficiency water structure breaker, inducing a disordered and discontinuous distribution of water molecules. Resultantly, an aqueous electrolyte composed of Mg(ClO4)2 features outstanding temperature resistance (solidification temperature below −60 °C), which supports a symmetrical supercapacitor to achieve stable operation, excellent cycle stability, and low capacitance loss (12% at 1 A g−1, 31% at 20 A g−1) from 25 to −60 °C. Furthermore, at −60 °C, a 2.4 V high working voltage is achieved with superior rate capability and high capacitance retention of 81.5% after continuous 30 000 cycles. Determining and mastering specific ion effects can provide a promising approach to designing and developing antifreezing aqueous electrolytes for energy storage at low temperatures.
Highly Off‐Centering Cations in Pavonite‐Structured Ag1.75InSb5.75Se11 with Competitive Thermoelectric Performance
Authors: Xie Chenghao , Li Rongcheng , Xu Weibin , Jin Bowen , Shi Xiao‐Lei , Tang Xinfeng , Tan Gangjian , Chen Zhi‐Gang 
Published: February 2025

AbstractOff‐centering represents the displacement of atoms from their centrosymmetric positions, a phenomenon closely associated with symmetry breaking in crystals and plays a crucial role in modulating a broad range of fundamental material properties. Herein, a pavonite‐structured compound Ag1.75InSb5.75Se11 (AISS) is reported, which exhibits highly off‐centering cations and systematically explores its potential as an advanced thermoelectric material. These findings reveal that the broken crystal symmetry of AISS induces a strong Rashba‐like band splitting, resulting in an overall high band degeneracy that contributes to large Seebeck coefficients. Additionally, low‐temperature heat capacity measurements and phonon spectrum calculations highlight the presence of soft chemical bonds between the off‐centering cations and Se atoms. These soft bonds give rise to low‐frequency optical phonons, which coupled with the acoustic phonons, thereby causing additional phonon scattering and leading to an extremely low lattice thermal conductivity of 0.22 W m−1K−1 at 723 K. Furthermore, optimizing the Ag/Sb atomic ratio in AISS enhances the doping level and improves the thermoelectric performance, resulting in a peak figure of merit value to 0.50 at 723 K in Ag2.5InSb5Se11, which is ≈30 times greater than that of pristine AISS.
Foams‐Induced Hierarchy for Multiscale Photonics on Flat Substrates: Lasing and Mie‐Bragg Diffraction as Case Studies.
Authors: Forzani Luisina , Tartaj Pedro , Luengo Yurena , Dalmis Ramazan , Moronta Pedro , Blanco Alvaro , López Cefe 
Published: February 2025

AbstractDensely packed arrays of monodisperse dielectric spheres exhibit strong optical diffraction down to the single‐layer limit, making them highly attractive for the implementation of order‐ and disorder‐based functionalities in photonic devices. Colloidal techniques are among the most convenient methods for creating these densely packed arrays, performing well on flat substrates. However, forming complex geometries with colloidal techniques usually requires patterned substrates and postprocessing routes. Here, a facile colloidal route capable of producing a complex configuration with two levels of functionality is described. Specifically, by foaming and casting colloidal suspensions of monodisperse spherical particles, both ordered and disordered arrays of densely packed spheres on unpatterned flat substrates are achieved. These arrays outline a complex cellular configuration consisting of a ridge‐trough network structure that supports random lasing action at the macroscale, while enabling Bragg diffraction (order) or Mie scattering (disorder) across the visible and near‐infrared spectral ranges at the microscale. Notably, the optical properties of the disordered foams can be effectively modeled using Mie calculations for individual spheres, serving as a valuable proof of concept for developing particulate portable detectors based on Mie resonances and a hierarchical configuration built upon a simple self‐assembly process carried out on flat substrates.
Brain‐Wide Neuroregenerative Gene Therapy Improves Cognition in a Mouse Model of Alzheimer's Disease
Authors: Wu Zheng , Xu Liang , Xie Yu , Sambangi Abhijeet , Swaminathan Shreya , Pei Zifei , Ji Wenyu , Li Zeru , Guo Yaowei , Li Zhifei , Chen Gong 
Published: February 2025

AbstractAlzheimer's disease (AD) is a progressive and irreversible brain disorder with extensive neuronal loss in the neocortex and hippocampus. Current therapeutic interventions focus on the early stage of AD but lack effective treatment for the late stage of AD, largely due to the inability to replenish the lost neurons and repair the broken neural circuits. In this study, by using engineered adeno‐associated virus vectors that efficiently cross the blood–brain‐barrier in the mouse brain, a brain‐wide neuroregenerative gene therapy is developed to directly convert endogenous astrocytes into functional neurons in a mouse model of AD. It is found that ≈500 000 new neurons are regenerated and widely distributed in the cerebral cortex and hippocampus. Importantly, it is demonstrated that the converted neurons can integrate into pre‐existing neural networks and improve various cognitive performances in AD mice. Chemogenetic inhibition of the converted neurons abolishes memory enhancement in AD mice, suggesting a pivotal role for the newly converted neurons in cognitive restoration. Together, brain‐wide neuroregenerative gene therapy may provide a viable strategy for the treatment of AD and other brain disorders associated with massive neuronal loss.