bluuebunny/crossref_metadata_2025_split huggingface dataset:
Just pluralism: thinking about concepts of mental disorder in global context
Authors: Popa Elena 
Published: August 2024

AbstractThis paper will investigate justice requirements that a pluralist stance on concepts of mental disorder should meet for use on a global scale. This is important given that different concepts of mental disorder are connected to particular interventions which may be more or less successful in specific contexts. While taking a broadly normative view on mental disorders, I will describe relevant concepts in a more fine grained manner, referring to their connections to particular approaches to biology, the self, or community. Drawing on research on epistemic injustice, I highlight the requirement that the set of multiple concepts be sufficiently flexible to enable the participation of those possessing relevant local knowledge. Using insights from health justice, I point out that the set of concepts should be conducive to distributive and procedural justice with regard to mental health and should support interventions on social determinants of health. These requirements apply to two dimensions of pluralism: regarding what concepts to include and how to relate them to one another. I conclude by explaining how an ontology of partial overlaps connected to a concept of health as metaphysically social can help address the challenges arising particularly regarding the latter dimension.
Venetoclax treatment for chronic lymphocytic leukemia/small lymphocytic leukemia in Japan: post-marketing surveillance
Authors: Ito Tomoki , Kamimura Tomohiko , Kiguchi Toru , Kato Koji , Takenaka Risa , Kobayashi Mariko , Ito Ayumi , Sakai Mizu , Izutsu Koji 
Published: August 2024

AbstractVenetoclax was approved for relapsed/refractory chronic lymphocytic leukemia (R/R CLL) and small lymphocytic leukemia (SLL) in Japan in September 2019; however, clinical data in Japanese patients are limited. This all-case post-marketing surveillance assessed efficacy and safety in Japanese patients with R/R CLL/SLL who started venetoclax treatment between November 2019 and August 2020. Overall, the safety and efficacy analysis sets included 129 and 114 patients, respectively. The overall response rate (ORR) was 57.0%; ORRs were higher in patients with versus without concomitant rituximab (65.4% vs. 54.7%), and in patients with 1 versus ≥ 2 prior lines of therapies (72.5% vs. 44.4%). Adverse events (AEs) were reported in 66.7% of patients (86/129); the most common AEs were neutrophil count decreased (22.5%), white blood cell count decreased (7.8%), and tumor lysis syndrome (TLS; 6.2%). AEs of special interest (TLS, myelosuppression, and infection) were manageable in clinical practice in Japan. Venetoclax is efficacious and safe for R/R CLL/SLL patients in the real-world setting in Japan. ClinicalTrials.gov ID: NCT04198415.
Diagnostic methodology for vehicles equipped with antilock braking system and electronic stability control
Authors: Betancur J. Alejandro , Castillo Andrés , Ramos Edwin , Vargas Héctor , Ochoa Javier , Sanchez Carlos 
Published: August 2024

AbstractCurrently, several automotive companies are joining forces through the analysis and development of active safety systems for hazard avoidance and mitigation; from which according to the current regulations in the European Union the Anti-lock Braking System (ABS) and the Electronic Stability Control (ESC) outstand as mandatory for each new vehicle. The above has motivated the study of these two safety systems. Then, this research examines the ABS and ESC systems through a proposed diagnostic methodology, which identifies the main effect of these systems on the vehicle dynamics. To achieve this goal a software was developed, looking for processing the data acquired during the development of some specific vehicle maneuvers. The diagnostic results expose: (1) an indicator about the ABS/ESC systems performance; and (2) the impact of these systems on the vehicle dynamics; also, some of the results here obtained can also be taken as reference for the Brake Assistant System and the Anti-Roll Control analysis.
High‐Resolution Ice‐Core Analyses Identify the Eldgjá Eruption and a Cluster of Icelandic and Trans‐Continental Tephras Between 936 and 943 CE
Authors: Hutchison William , Gabriel Imogen , Plunkett Gill , Burke Andrea , Sugden Patrick , Innes Helen , Davies Siwan , Moreland William M. , Krüger Kirstin , Wilson Rob , Vinther Bo M. , Dahl‐Jensen Dorthe , Freitag Johannes , Oppenheimer Clive , Chellman Nathan J. , Sigl Michael , McConnell Joseph R. 
Published: August 2024

AbstractThe Eldgjá eruption is the largest basalt lava flood of the Common Era. It has been linked to a major ice‐core sulfur (S) spike in 939–940 CE and Northern Hemisphere summer cooling in 940 CE. Despite its magnitude and potential climate impacts, uncertainties remain concerning the eruption timeline, atmospheric dispersal of emitted volatiles, and coincident volcanism in Iceland and elsewhere. Here, we present a comprehensive analysis of Greenland ice‐cores from 936 to 943 CE, revealing a complex volatile record and cryptotephra with numerous geochemical populations. Transitional alkali basalt tephra matching Eldgjá are found in 939–940 CE, while tholeiitic basalt shards present in 936/937 CE and 940/941 CE are compatible with contemporaneous Icelandic eruptions from Grímsvötn and Bárðarbunga‐Veiðivötn systems (including V‐Sv tephra). We also find four silicic tephra populations, one of which we link to the Jala Pumice of Ceboruco (Mexico) at 941 ± 1 CE. Triple S isotopes, Δ33S, spanning 936–940 CE are indicative of upper tropospheric/lower stratospheric transport of aerosol sourced from the Icelandic fissure eruptions. However, anomalous Δ33S (down to −0.4‰) in 940–941 CE evidence stratospheric aerosol transport consistent with summer surface cooling revealed by tree‐ring reconstructions. Tephra associated with the anomalous Δ33S have a variety of compositions, complicating the attribution of climate cooling to Eldgjá alone. Nevertheless, our study confirms a major S emission from Eldgjá in 939–940 CE and implicates Eldgjá and a cluster of eruptions as triggers of summer cooling, severe winters, and privations in ∼940 CE.
First High‐Resolution Vertical Profiles of Methane in the Troposphere Over India
Authors: Tiwari Yogesh K. , Gupta Smrati , Fernandez Rafael P. , Cuevas Carlos A. , Li Qinyi , Saiz‐Lopez Alfonso , Mahajan Anoop S. 
Published: August 2024

AbstractMethane (CH4) is the second most abundant greenhouse gas and affects the Earth's radiative balance. In some regions, the methane burden and budget are still not well understood due to the lack of in situ observations, especially vertical profile observations. Here, we present the first high‐resolution aircraft‐based tropospheric vertical profiles of CH4 across the Indian subcontinent. Observations show significant variability, with the largest variability seen in the Indo‐Gangetic Plain (IGP) during post‐monsoon (September). The IGP also shows the highest concentrations and a peak in the boundary layer. By contrast, observations over western India show lower variability, especially during the Asian Summer Monsoon (ASM) (July). During ASM, when CH4 emissions peak, the vertical updraft of CH4 and other tracers is observed, leading to a peak between 4 and 5 km. During winter, the peak occurs in the boundary layer, and a decrease with altitude is observed. Model simulations slightly overestimate CH4 at the surface during some seasons but underestimate it at higher altitudes during all seasons. Integrated over the observed column, model simulations slightly underpredict CH4 (0.5%–3.1%) during all seasons. Calculations made using the observed CO/CH4 enhancement ratios show that in addition to anthropogenic fossil fuel emissions, other sources, such as rice cultivation and wetlands, need to be considered to reproduce the observed CH4 concentrations.
The control rate of hypertension across months of year and hours of day in a large real-world database
Authors: Yan Qinghua , Cheng Minna , Xu Wenli , Cheng Yibang , Wu Fei , Wang Yuheng , Yang Qinping , Shi Yan , Wang Jiguang 
Published: August 2024

AbstractWe investigated the control rate of hypertension across months of year and hours of day in a real-world database. The study participants were hypertensive patients from 142 community health centers across 16 districts in Shanghai, China, who measured their blood pressure with an automatic office blood pressure measurement platform between 2018 and 2023. The 343,400 hypertensive patients included 53.7% of women, and had average age of 70.2 (±8.1) years (range 50–90 years). For months of year, the control rate of hypertension was lowest in February and highest in August (51.9% vs 71.8%). For hours of day, the control rate of hypertension was lowest at 7:00 AM and highest at 12:00 PM (52.1% vs 76.0%). When the months of year and hour of day were considered together, the control rate was lowest at 7 AM in February (42.1%), and highest at 12 PM in July (86.8%). In 8516 patients who had uncontrolled blood pressure in the early morning and had their blood pressure also measured around noon, 45.7% had masked uncontrolled morning hypertension, with higher rates in spring and summer, and in women, those aged 50-69 years, and non-diabetic patients. The control rate of hypertension varies greatly across months of year and hours of day, suggesting that the evaluation of blood pressure control has to take into full consideration the measurement time in terms of months and hours.
Novel mechanisms of MITF regulation identified in a mouse suppressor screen
Authors: Vu Hong Nhung , Valdimarsson Matti Már , Sigurbjörnsdóttir Sara , Bergsteinsdóttir Kristín , Debbache Julien , Bismuth Keren , Swing Deborah A , Hallsson Jón H , Larue Lionel , Arnheiter Heinz , Copeland Neal G , Jenkins Nancy A , Heidarsson Petur O , Steingrímsson Eiríkur 
Published: August 2024

AbstractMITF, a basic Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. We perform a genetic screen for suppressors of the Mitf-associated pigmentation phenotype in mice and identify an intragenic Mitf mutation that terminates MITF at the K316 SUMOylation site, leading to loss of the C-end intrinsically disordered region (IDR). The resulting protein is more nuclear but less stable than wild-type MITF and retains DNA-binding ability. As a dimer, it can translocate wild-type and mutant MITF partners into the nucleus, improving its own stability thus ensuring nuclear MITF supply. smFRET analysis shows interactions between K316 SUMOylation and S409 phosphorylation sites across monomers; these interactions largely explain the observed effects. The recurrent melanoma-associated E318K mutation in MITF, which affects K316 SUMOylation, also alters protein regulation in concert with S409. This suggests that residues K316 and S409 of MITF are impacted by SUMOylation and phosphorylation, respectively, mediating effects on nuclear localization and stability through conformational changes. Our work provides a novel mechanism of genetic suppression, and an example of how apparently deleterious mutations lead to normal phenotypes.
Microlensing brown-dwarf companions in binaries detected during the 2022 and 2023 seasons
Authors: Han Cheongho , Bond Ian A. , Udalski Andrzej , Lee Chung-Uk , Gould Andrew , Albrow Michael D. , Chung Sun-Ju , Hwang Kyu-Ha , Jung Youn Kil , Ryu Yoon-Hyun , Shvartzvald Yossi , Shin In-Gu , Yee Jennifer C. , Yang Hongjing , Zang Weicheng , Cha Sang-Mok , Kim Doeon , Kim Dong-Jin , Kim Seung-Lee , Lee Dong-Joo , Lee Yongseok , Park Byeong-Gon , Pogge Richard W. , Abe Fumio , Bando Ken , Barry Richard , Bennett David P. , Bhattacharya Aparna , Fujii Hirosame , Fukui Akihiko , Hamada Ryusei , Hamada Shunya , Hamasaki Naoto , Hirao Yuki , Silva Stela Ishitani , Itow Yoshitaka , Kirikawa Rintaro , Koshimoto Naoki , Matsubara Yutaka , Miyazaki Shota , Muraki Yasushi , Nagai Tutumi , Nunota Kansuke , Olmschenk Greg , Ranc Clément , Rattenbury Nicholas J. , Satoh Yuki , Sumi Takahiro , Suzuki Daisuke , Tomoyoshi Mio , Tristram Paul J. , Vandorou Aikaterini , Yama Hibiki , Yamashita Kansuke , Mróz Przemek , Szymański Michał K. , Skowron Jan , Poleski Radosław , Soszyński Igor , Pietrukowicz Paweł , Kozłowski Szymon , Rybicki Krzysztof A. , Iwanek Patryk , Ulaczyk Krzysztof , Wrona Marcin , Gromadzki Mariusz , Mróz Mateusz J. 
Published: August 2024

Aims. Building on previous works to construct a homogeneous sample of brown dwarfs in binary systems, we investigate microlensing events detected by the Korea Microlensing Telescope Network (KMTNet) survey during the 2022 and 2023 seasons.
Methods. Given the difficulty in distinguishing brown-dwarf events from those produced by binary lenses with nearly equal-mass components, we analyze all lensing events detected during the seasons that exhibit anomalies characteristic of binary-lens systems.
Results. Using the same criteria consistently applied in previous studies, we identify six additional brown dwarf candidates through the analysis of lensing events KMT-2022-BLG-0412, KMT-2022-BLG-2286, KMT-2023-BLG-0201, KMT-2023-BLG-0601, KMT-2023-BLG-1684, and KMT-2023-BLG-1743. An examination of the mass posteriors shows that the median mass of the lens companions ranges from 0.02 M⊙ to 0.05 M⊙, indicating that these companions fall within the brown-dwarf mass range. The mass of the primary lenses ranges from 0.11 M⊙ to 0.68 M⊙, indicating that they are low-mass stars with substantially lower masses compared to the Sun.
From 100 MHz to 10 GHz: Unveiling the spectral evolution of the X-shaped radio galaxy in Abell 3670
Authors: Bruno L. , Brienza M. , Zanichelli A. , Gitti M. , Ubertosi F. , Rajpurohit K. , Venturi T. , Dallacasa D. 
Published: August 2024

Context. X-shaped radio galaxies (XRGs) are characterised by two pairs of misaligned lobes: active lobes hosting radio jets and the wings. None of the formation mechanisms proposed thus far are able to exhaustively reproduce the diverse features observed among XRGs. Emerging evidence has proposed the existence of sub-populations of XRGs forming via different processes.
Aims. The brightest cluster galaxy (BCG) in Abell 3670 (A3670) is a dumbbell system hosting the XRG MRC 2011-298. The morphological and spectral properties of this interesting XRG were first characterised based on Karl G. Jansky Very Large Array (JVLA) data at 1–10 GHz. In the present work, we follow up on MRC 2011-298 with the upgraded Giant Metrewave Radio Telescope (uGMRT) at 120–800 MHz to further constrain its properties and origin.
Methods. We carried out a detailed spectral analysis sampling different spatial scales. Integrated radio spectra, spectral index maps, radio colour-colour diagrams, and radiative age maps of both the active lobes and prominent wings were employed to test the origin of the source.
Results. We confirm a progressive spectral steepening from the lobes to the wings. The maximum radiative age of the source is ~80 Myr, with the wings being older than the lobes by ≳30 Myr in their outermost regions.
Conclusions. The observed properties are in line with an abrupt reorientation of the jets by ~90 deg from the direction of the wings to their present position. This formation mechanism is further supported by the comparison with numerical simulations in the literature, which additionally highlight the role of hydrodynamic processes in the evolution of large wings such as those of MRC 2011-298. It is plausible that the coalescence of supermassive black holes could have triggered the spin-flip of the jets. Moreover, we show that the S-shape of the radio jets is likely driven by precession with a period of P ~ 10 Myr.
Computing regularized splines in the Riemannian manifold of probability measures
Authors: Tam Tran Tien , Adouani Ines , SAMIR Chafik 
Published: August 2024

In this paper, we give new numerical methods to solve $C^{2}$ splines for interpolating a finite set of probability measures. Due to the difficulties of generalizing interpolations and solving them with explicit expressions on manifolds, we first introduce a theoretical analysis with different structures on the Riemannian manifold of probability measures $\mathcal{P} _{+}(I)$. Then, by combining standard numerical methods and a new mathematical modeling we generalize interpolating splines as a minimizer of an energy functional on $\mathcal{P} _{+}(I)$. Finally, we show the efficiency of the proposed methods and their computational relevance with several applications.
Lameness prevalence in lactating and dry cows – expert's,
student's and farmers' assessments
Authors: Laschinger Jasmin , Linnenkohl Sophie , Fuerst-Waltl Birgit , Kofler Johann 
Published: August 2024

Abstract
Objective The aim of this study was to evaluate differences in lameness
prevalence among Austrian dairy farms for both lactating and dry cows as
assessed by locomotion scoring (LCS 1–5) by an expert and a student who had
received brief training in locomotion scoring and by farmers’ estimates and by
farmers’ lameness assessments.
Materials and methods In total, 632 cows from 11 farms were evaluated,
including 553 lactating and 79 dry cows. Lameness prevalence was calculated for
all farms collectively as well as for individual farms. The ratio of lameness
prevalence determined by the student/expert (Student’s Assessment Index: SAI),
the ratio between farmers’ assessments/expert assessments (Farmers’ Assessment
Index: FAI) and the ratio between farmers’ estimates/expert assessments
(Farmers’ Detection Index: FDI) were calculated.
Results For the expert, the mean lameness prevalence (LCS≥2) among all 632
cows was 63.1%, while for the student it was 60.2%, and the farmers’ assessment
was 37.3%, resulting in a mean difference of 25.8% between the expert and the
farmers. In cows with LCS 2, the SAI was 99.6%, in cows with LCS 3, it was
84.4%, and in cows with LCS≥4, it was 88.6%. The mean FDI and FAI for all cows
on the 11 farms were 35.1% and 58.2%, respectively, with wide variation across
farms (6.8–79.1% and 17.8–94.7%, respectively). Overall, lactating and dry cows
exhibited a high mean lameness prevalence (63.9% vs. 59.6%), which differed by
only 4.3%.
Conclusions and clinical relevance Farmers should actively assess their
cattle for lameness on a regular basis. Moreover, they should be trained to
identify lame cows (lactating and dry cows), especially those showing mild
lameness (LCS 2). Since the recently trained student achieved similar high
recognition rates as the expert, it is assumed that a training in locomotion
scoring can contribute to higher recognition rates.
Erstmaliger Nachweis des SLC2A9:p.C188F Gendefekts bei einem
Deutschen Jagdterrier mit Ammoniumurat-Urolithiasis
Authors: Emming Christin , Hadjiafxentis Michael , Liesegang Annette , Gampe Lukas 
Published: August 2024

ZusammenfassungEin 1,5-jähriger, männlich intakter Deutscher Jagdterrier wurde erstmalig 2018
mit Hämaturie vorstellig. In einer abdominalen Ultraschalluntersuchung wurden
multiple hyperechogene Strukturen in der Harnblase festgestellt. Eine
Urinuntersuchung wies auf eine hochgradige Ammoniumurat- oder
Xanthin-Kristallurie hin. Erst nach einer Zystotomie und einer Harnsteinanalyse
konnte 2019 eine Ammoniumurat-Urolithiasis diagnostiziert werden. Der Patient
wurde homozygot für die SLC2A9:p.C188F Variante, welche in eine
hochgradige Hyperurikämie und Hyperurikosurie resultiert, getestet. Diese
Kasuistik berichtet über den ersten publizierten Fall eines Deutschen
Jagdterriers, bei dem die SLC2A9:p.C188F Variante nachgewiesen wurde. Die
Leserschaft soll dafür sensibilisiert werden, dass dieser Gendefekt auch in
anderen Rassen als Dalmatinern auftreten kann.
Abdominale Aortenmalformation bei 2 Hunden
Authors: Jährig Rodja Aljoscha , Paulus Christiane , Brinkmeier Hannah , Kroeblin Anne , Güssow Arne , Hartung Svenja , Schaub Sebastian , Schneider Matthias Alois 
Published: August 2024

ZusammenfassungAneurysmen der Aorta abdominalis sind in der tierärztlichen Literatur nur
vereinzelt dokumentiert. Diese Veröffentlichung beschreibt 2 Fälle beim Hund,
bei welchen jeweils eine abdominale Aortenmalformation mittels Sonografie
festgestellt und mittels Computertomografie bestätigt werden konnte. In einem
Fall konnte histologisch die Diagnose eines Aortenaneurysmas gestellt
werden.Ein Hund zeigte eine Hinterhandschwäche, beim zweiten Hund war das
Aortenaneurysma bei einer Routineuntersuchung sonografisch aufgefallen.Bei dem ersten Patienten mit dem nachgewiesenen Aortenaneurysma besteht die
Vermutung, dass aufgrund des veränderten Flussprofils und der auftretenden
Turbulenzen eine hämodynamisch relevante Komponente vorliegt. Entsprechend
humanmedizinischen Standards erscheint daher eine regelmäßige Überwachung dieser
Patienten, sowohl klinisch als auch mittels Sonografie, sinnvoll, um so ein
Auftreten oder Fortschreiten sekundärer hämodynamischer Veränderungen und eine
eventuelle Thrombenbildung frühzeitig erkennen zu können. Der zweite hier
vorgestellte Fall zeigt im Gegensatz dazu bis zum aktuellen Zeitpunkt keine
klinischen Symptome hinsichtlich seiner abdominalen Gefäßmalformation.
Twenty-Three Years of Declining Lithium Use: Analysis of a
Pharmacoepidemiological Dataset from German-Speaking Countries
Authors: Greil Waldemar , de Bardeci Mateo , Nievergelt Nadja , Toto Sermin , Grohmann Renate , Seifert Johanna , Schoretsanitis Georgios 
Published: August 2024

Abstract
Introduction Pharmacoepidemiological data suggest that lithium
prescriptions for bipolar disorder are gradually decreasing, with less attention
having been paid to other indications.
Methods We examined lithium prescriptions between 1994 and 2017 in data
provided by the Drug Safety in Psychiatry Program AMSP, including psychiatric
hospitals in Germany, Austria and Switzerland. We compared lithium use for
different diagnoses before and after 2001 and in three periods (T1: 1994–2001,
T2: 2002–2009, and T3: 2010–2017).
Results In a total of 158,384 adult inpatients (54% female, mean age
47.4±17.0 years), we observed a statistically significant decrease in lithium
prescriptions between 1994–2000 and 2001–2017 in patients with schizophrenia
spectrum disorder from 7.7% to 5.1% and in patients with affective disorders
from 16.8% to 9.6%. Decreases in use were also observed for diagnostic
subgroups: schizoaffective disorder (ICD-10 F25: 27.8% to 17.4%), bipolar
disorder (F31: 41.3% to 31%), depressive episode (F32: 8.1% to 3.4%), recurrent
depression (F33: 17.9% to 7.5%, all: p<0.001) and emotionally unstable
(borderline) personality disorder (6.3% to 3.9%, p=0.01). The results in T1 vs.
T2 vs. T3 were for F25: 26.7% vs. 18.2% vs. 16.2%, F32: 7.7% vs. 4.2% vs. 2.7%,
F33: 17.2% vs. 8.6% vs. 6.6% and for F31: 40.8% vs. 31.7% vs 30.0%, i. e. there
was no further decrease for lithium use in bipolar disorder after 2002.
Lithium’s main psychotropic co-medications were quetiapine (21.1%), lorazepam
(20.6%), and olanzapine (15.2%).
Discussion In inpatients, the use of lithium has decreased in patients
with bipolar disorder and also with various other psychiatric diagnoses.
Besser arbeiten
Authors: Pintarelli-Rauschenbach Manuela 
Published: August 2024

ZusammenfassungErinnern Sie sich noch? Was war bei Ihrer Berufswahl ausschlaggebend dafür, dass Sie eine
physiotherapeutische Ausbildung angesteuert haben? Wir wollten von angehenden Therapeut*innen wissen, was
sich ändern müsste, damit mehr junge Menschen die Physiotherapie als Berufsweg wählen. Lesen Sie auf den
VPT Campus-Seiten (► Seite 14), wie differenziert die Befragten antworteten. Wir
machen uns auf allen politischen Ebenen dafür stark, dass unser schöner Beruf attraktiv bleibt, die
Arbeit Freude macht und die Vergütung stimmt. Unser Campus-Team (► Seite 16) behält dafür immer
ein Ohr am Physio-Nachwuchs.