bluuebunny/crossref_metadata_2025_split huggingface dataset:
Is fat quantification based on proton density fat fraction useful for differentiating renal tumor types?
Authors: Altay Canan , Akın Işıl Başara , Özgül Hakan Abdullah , Şen Volkan , Bozkurt Ozan , Tuna Emine Burçin , Yörükoğlu Kutsal , Seçil Mustafa 
Published: July 2024

Abstract

Purpose: This study retrospectively assessed the diagnostic accuracy of fat quantification based on PDFF for differentiating renal tumors.
Methods: In this retrospective study, 98 histologically confirmed clear cell renal cell carcinomas (RCCs), 35 papillary RCCs, 14 oncocytomas, 16 chromophobe RCCs, 10 lymphomas, 19 uroepithelial tumors, 10 lipid-poor angiomyolipomas (AMLs), and 25 lipid-rich AMLs were identified in 226 patients (127 males and 99 females) over 5 years. All patients underwent multiparametric kidney MRI. Demographic data were recorded, and PDFF values were independently reviewed by two radiologists blinded to pathologic results. MRI examinations were performed using a 1.5 T system. MRI-PDFF measurements were obtained from the solid parts of all renal tumors. Fat quantification was performed using a standard region of interest for each tumor, compared to histopathological diagnoses. Sensitivity and specificity analyses were performed to calculate the diagnostic accuracy for each histopathological tumor type. P-values < 0.05 were considered statistically significant.
Results: In all, 102 patients underwent partial nephrectomy, 70 patients underwent radical nephrectomy, and the remaining 54 had biopsies. Patient age (mean: 58.11 years; range: 18–87 years) and tumor size (mean: 29.5 mm; range: 14–147 mm) did not significantly differ across groups. All measurements exhibited good interobserver agreement. Clear cell RCCs presented a significantly higher fat ratio than other RCC types, uroepithelial tumors, lymphomas, and lipid-poor AMLs. Lipid-rich AMLs demonstrated a very high fat ratio.
Conclusion: MRI-PDFF facilitated accurate differentiation of clear cell RCCs from other renal tumors with high sensitivity and specificity.
The Rising Threat of Liver Cancer in Patients with Cirrhosis: Are Indeterminate Liver Nodules Cause for Concern? Real-world, long-term follow-up data
Authors: Yahia Yousef , Qasem Ma'mon , Abbarh Shahem , Saffo Husam , Obeidat Ibrahim M. , Barjas Haidar Hussein , Faisal Mohanad Mohammed , Halabiya Malik , Chandra Prem , Derbala Moutaz 
Published: July 2024

Abstract

Background:
Several studies have shown a higher risk of liver cancer from indeterminate liver nodules, but the exact occurrence and predictors of liver cancer in this group are still unclear. Our aim is to study the development of liver cancer in this population and identify any potential risk factors.
Methods:
This retrospective study evaluated cirrhotic patients with indeterminate liver nodules from 2013 to 2023.Data from electronic patient records was analyzed to assess the association between HCC and baseline factors.Subgroup exploratory analysis compared characteristics of patients with de novo HCC and those with nodule transformation HCC.
Results:
Out of 116 patients with liver nodules, 19 (16%) developed HCC in up to 7.5-year follow-up. Univariate Cox regression analysis showed a significant association between HCC incidence and smoking [hazard ratio (HR) 2.60, 95% Confidence Interval [CI] 1.01-6.74), nodule diameter exceeding 2cm (HR 5.41, 95% CI 1.45-20.18), and baseline LI-RADS score 3 (HR 3.78, 95% CI 1.36-19.52). Multivariate Cox regression analysis revealed significant independent associations with nodule diameters 1 cm to <2cm (adjusted HR 3.35, 95% CI 1.06-10.60) and greater than 2cm (adjusted HR 5.85, 95% CI 1.10-31.16), as well as with LI-RADS 3 lesions (adjusted HR 3.75, 95% CI 1.16-12.11) with adjusting other potential predictors and covariates.
Conclusion:
Our findings show a higher incidence of HCC in patients with indeterminate liver nodules, increasing over time and reaching 30% at seven years. Nodules larger than 1-2 cm or LI-RADS 3 lesions pose increased risk for HCC. Enhanced surveillance is necessary given the lack of clear management guidelines.
Cardiac Events Occurring after Allogeneic Hematopoietic Cell Transplantation with Post-Transplant Cyclophosphamide. Study Conducted on Behalf of the GETH-TC
Authors: Salas Maria Queralt , Cascos Enric , López-García Alberto , Pérez Estefanía , Baile Mónica , Corral Lucía López , Pascual María , Luque Marta , Esqu Albert , Heras Inmaculada , Ormategi Itziar Oiartzabal , Marín Adolfo Sáez , Peña-Muñóz Felipe , Fernandez-Luis Sara , Domínguez-García Juan , Villar Sara , Girón Miguel Fernández de Sanmamed , González-Pinedo Leslie , Gonzalez-Rodriguez Ana Pilar , Torrado Tamara , Garcia-Mañó Lucia , Filaferro Silvia , Cedillo Ángel , Basalobre Pascual , Orti Guillermo , Jurado Manuel 
Published: July 2024

Abstract

This multicenter study investigates the incidence and predictors of cardiac events (CE) following allo-HCT with PTCY in 453 AML patients. CE occurred in 67 (14.3%) patients within a median of 81 days (IQR: 13-380), with day 100 and 5-year cumulative incidences of 8.2% and 15.3%. Early (first 100 days) and late CE occurred at rates of 8.2% and 6.2%. The most prevalent CE were heart failure (n=21, 32.8%), arrhythmia (n=17, 26.6%), and pericardial complications (n=16, 25%). The proportions of patients older than 50 years (73.4% vs. 59.4%, P=0.032), with hypertension (34.9% vs. 18.3%, P=0.001), dyslipidemia (26.6% vs. 11.1%, P=0.001), and undergoing haplo-HCT (70.3% vs. 55.8%, P=0.029) were higher in patients with CE. However, the multivariate regression analysis revealed that only hypertension (HR 2.02, P=0.015) and dyslipidemia (HR 2.20, P=0.015) were predictors for CE, with no differences according to donor type (haplo-HCT vs. others: HR 1.49, P=0.151). Among the 64 patients with CE, the mortality rate was 10.9%. Notably, the diagnosis of CE negatively impacted NRM (HR 2.40, P=0.013) and OS (HR 1.79, P=0.014), underscoring necessity of aggressively treating cardiovascular risk factors, and implementing post-transplant cardiac monitoring protocols to prevent these complications.
A Novel Method for Enhancing the Identification of Attacks in Wireless Sensor Networks via Improved Naive Bayes
Authors: Nithiyananda N. , Rajesh M. , Rodrigues Joel J. P. C. 
Published: July 2024

Abstract

Using feature weighting based on Jensen-Shannon divergence and inverse category frequency (ICF), this research introduces JINB, an improved Naive Bayes (NB) classifier, so that network intrusion detection can be more precise. The technique uses the JINB algorithm for network event classification after feature weights are determined according to their situational importance. By utilising the NSL-KDD dataset, we were able to validate the algorithm's performance, which showed considerable enhancements in detection accuracy, decreased false alarm rates, and efficient real-time processing. When compared experimentally to other algorithms, like OAA, SVM, IBT, HNB, and XLSTM, JINB proves to be the most effective in identifying different forms of attacks in WSNs without sacrificing energy economy. The findings show that JINB is an efficient, accurate, and cost-effective way to identify intrusions in networks in real-time.
Complex mechanical properties of 3D micro-metric pantographic metamaterials fabricated by two-photon polymerization
Authors: Barchiesi Emilio , Mavrikos Stefanos , Giorgio Ivan , Grigoropoulos Costas , Farsari Maria , dell’Isola Francesco , Zyla Gordon 
Published: July 2024

Abstract

Mechanical metamaterials consist of specially engineered features designed to tailor and enhance the mechanical properties of their constituent materials. In this context, 2D pantographic fabrics have gained attention for their unique deformation behavior, providing remarkable resilience and damage tolerance. This study explores micro-metric metamaterials with 3D pantographic motifs, aiming to transfer these properties to small scales. 3D micro-metric structures were designed using 2D pantographic fabrics arranged in multiple layers, each featuring unit cells with quasi-perfect pivots. Relatively large specimens of 3D micro-metric pantographs, measuring 158μm x 250 μm x 450 μm, were fabricated using two-photon polymerization in various configurations. These specimens were mechanically characterized through in-situ scanning electron microscopy microindentation under conditions of cyclic deformation. Structural failures were subsequently assessed via helium-ion microscopy. The 3D micro-metric pantographs exhibited complex mechanical properties, some aligning with those of 2D pantographic fabrics, while new properties, such as a dissipative response and softening, were identified. Nonetheless, the 3D micro-metric pantographs demonstrated great resilience against deformation and enhanced resistance to undesired out-of-plane motions, indicating their potential for novel applications in advanced engineering fields. Additionally, the findings can potentially lead to optimizing and enriching theoretical models describing the mechanical behavior of pantographic metamaterials.
Immune Checkpoint Inhibitors in first versus second line of metastatic non-small cell lung cancer: Real-World Overall Survival
Authors: Yudin D. I. , Laktionov К. К. , Breder V. V. , Sarantseva K. A. , Reutova E. V. 
Published: July 2024

Introduction. Although immuneand targeted therapy have become successful in recent years, platinum-based chemotherapy continues to have a place in the up-front treatment for metastatic non-small cell lung cancer (NSCLC).Aim. Tо evaluate the overall survival (OS) of patients with metastatic NSCLC who were treated with immune checkpoint inhibitors either as first-line or second-line treatment in clinical practice in Russia.Materials and methods. Using real-world database, we retrospectively selected 232 patients with metastatic NSCLC without driving mutations. Of these patients, 82 received chemoimmunotherapy as the initial treatment (group 1) and 150 patients were treated with platinum–based chemotherapy followed by immunotherapy as the second line (group 2). Multivariate subgroup analyses were performed. The median time from the start of treatment to data cut off was 38.4 months.Results. The median OS was the same in the first and second group, 21.0 months (14.4–27.6; 95% CI) and 22.4 months (17.6–27.19; 95% CI); estimated 3-year OS was 40% and 36.6%, respectively. The hazard ratio (HR) for patients in the immunochemotherapy group was 1.02 (0.72–1.44; 95% CI) compared with patients who received second-line immunotherapy. In multivariate analysis, non-compliance with basic inclusion criteria in clinical trials (ECOG 2–3, serious intercurrent illness, active infection, chronic infection, corticosteroids need) (HR = 1.71 (1.21–2.4; 95% CI), the liver metastasis (HR = 1.76 (1.09–2.84; 95% CI) and gender (male vs. female HR = 1.68 (1.04–2.71; 95% DI) were significantly associated with the shorter OS.Conclusions. The overall survival in patients who received immunotherapy in the second line of treatment did not differ from the results of treatment for the patients after immuno-chemotherapy in the first line. The crucial is the receiving of immunotherapy regardless of the line. Failure to meet the criteria of inclusion in clinical trials significantly worsens the long-term outcomes.
Long-term outcomes of durvalumab after chemoradiotherapy in locally advanced non-small cell lung cancer in Russia
Authors: Yudin D. I. , Laktionov К. К. , Moiseenko F. V. , Ponomarenko D. M. , Сhernykh M. V. , Chubenko V. A. , Levchenko N. V. , Kozlov V. V. , Stepanova E. О. , Khagazheeva M. N. , Yukalchuk D. Yu. 
Published: July 2024

Introduction. The results of the PACIFIC trial have changed the standards of care for the patients with unresectable stage III nonsmall cell lung cancer (NSCLC). However, many patients in our clinical practice do not meet the inclusion criteria of PACIFIC trial.Aim. To evaluate the long-term outcomes for this approach in real clinical practice in Russia.Materials and мethods. This real-world observational retrospective multicenter study analyzed clinical outcomes in 100 patients with unresectable stage III NSCLC after concurrent or sequential chemoradiotherapy (CRT). The overall survival (OS) and progression-free survival (PFS) were evaluated by the Kaplan-Meyer method. Multivariate subgroups analysis was performed as well. The median follow-up time was 22.7 months.Results. There were 96% patients with ECOG/WHO performance status 0 or 1 in our study. Most of the patients were treated by sequential CRT (76%). Median time of durvalumab start from the end of CRT was 34 days. Patients received durvalumab for a median 10 months. The estimated median progression-free survival (PFS) and overall survival (OS) were 14.3 months (11.8–16.7, 95% CI) and 29 months (18.7–39.2, 95% CI), respectively. The estimated 1-year and 2-year rates for OS and for PFS were 90.4%, 62.8% and 59.1%, 35%, respectively. In multivariate analysis, a smoking history (HR = 0.21 (0.10–0.45; 95% CI) and concurrent CRT (HR = 0.3 (0.12–0.74; 95%CI) were associated with better PFS. The smoking history was significantly associated with a better OS (HR = 0.29 (0.10–0.76; 95% CI)) as well.Conclusions. There is a difference between the real-world outcomes for patients with unresectable stage III NSCLC in Russia and the PACIFIC trial. Sequential CRT is the most frequent treatment option for locally advanced unresectable NSCLC in Russia, and estimated OS and PFS are shorter than in the PACIFIC clinical trial. A paradigm shift in chemoradiotherapy to the concurrent and personalized approach could change the current situation.
Studi Penilaian Indeks Kinerja Irigasi Dan Angka Kebutuhan Nyata Operasi Dan Pemeliharaan (Aknop) Pada Daerah Irigasi Kali Biru Kecamatan Ngajum Kabupaten Malang
Authors: Gozali Bayu Achmad , Runi Asmaranto  , Very Dermawan  
Published: July 2024

Daerah Irigasi Kali Biru memiliki bangunan pengambilan yang terletak pada Kecamatan Ngajum Kabupaten Malang. Ada 2 titik pengambilan pada bangunan tersebut, yang menjadi saluran Primer Ubalan (110 ha) dan saluran Primer Baba’an (66 ha). Hasil inventarisasi yang dilakukan pada tahun 2022, terdapat 26 titik kerusakan pada saluran yang diakibatkan oleh 1 sedimen dan 25 kerusakan lining saluran. Untuk indeks kinerja irigasi dari Daerah Irigasi Kali Biru mendapatkan nilai sebesar 78,66% (Kondisi Sedang) dengan aspek prasarana fisik sebesar 39,00%, aspek produktivitas tanam 13,83%, aspek sarana penunjang O&P sebesar 7,15%, aspek organisasi dan personalia sebesar 10,93%, aspek dokumentasi sebesar 3,30%, dan aspek perkumpulan petani pemakai air sebesar 4,45%. Perhitungan prioritas Daerah Irigasi Kali Biru dengan menggunakan metode peringkat dimana mengurutkan dari besaran nilai aset terendah ke tertinggi. Sehingga didapatkan hasil dimana 9 aset dengan kondisi sedang, 21 aset dalam kondisi baik, dan 40 dalam kondisi baik sekali. Dengan penanganan rehabilitasinya didapatkan 9 aset membutuhkan pemeliharaan berkala bersifat perbaikan, 21 aset membutuhkan pemeliharaan berkala bersifat perawatan, dan 40 aset cukup dilakukan pemeliharaan rutin. Perhitungan AKNOP didapatkan sebesar Rp. 322.235.852,00 dengan Rp. 63.312.860,00 untuk biaya operasi dan Rp. 258.922.992,00 untuk biaya pemeliharaan.
A Participatory Model for Cocreating Accessible Rehabilitation Technology for Stroke Survivors: User-Centered Design Approach
Authors: Kerr Andrew , Grealy Madeleine , Slachetka Milena , Wodu Chioma Obinuchi , Sweeney Gillian , Boyd Fiona , Colville David , Rowe Philip 
Published: July 2024

Abstract

Background
Globally, 1 in 3 people live with health conditions that could be improved with rehabilitation. Ideally, this is provided by trained professionals delivering evidence-based dose, intensity, and content of rehabilitation for optimal recovery. The widely acknowledged inability of global health care providers to deliver recommended levels of rehabilitation creates an opportunity for technological innovation. Design processes that lack close consideration of users’ needs and budgets, however, mean that many rehabilitation technologies are neither useful nor used. To address this problem, our multidisciplinary research group have established a cocreation center for rehabilitation technology that places the end user at the center of the innovation process.

Objective
This study aims to present the participatory cocreation model that has been developed from our center and illustrate the approach with 2 cases studies.

Methods
The model is built around user participation in an intensive rehabilitation program (2-hour sessions, 2‐5 times per week, and 8-week duration), supervised by qualified therapists but delivered exclusively through commercial and prototype technology. This provides participants (chronic stroke survivors with movement and/or speech disability) with a rich experience of rehabilitation technology, enabling them to provide truly informed feedback, as well as creating an observatory for the research team. This process is supported by short-term focus groups for specific product development and a longer-term advisory group to consider broader issues of adoption and translation into everyday health care.

Results
Our model has been active for 3 years with 92 (92%) out of 100 participants completing the program. Five new technologies have evolved from the process with further ideas logged for future development. In addition, it has led to a set of cocreated protocols for technology-enriched rehabilitation, including recruitment, outcome measures, and intervention structure, which has allowed us to replicate this approach in an acute hospital ward.

Conclusions
Suboptimal rehabilitation limits recovery from health conditions. Technology offers the potential support to increase access to recommended levels of rehabilitation but needs to be designed to suit end users and not just their impairment. Our cocreation model, built around participation in an intensive, technology-based program, has produced new accessible technology and demonstrated the feasibility of our overall approach to providing the rehabilitation that people need, for as long as needed.
The Regional Government Leaders Ambiguous Position and Political Influence in Indonesia’s Civil Servant Management
Authors: Hardenta Alif Duta 
Published: July 2024

The regional government leaders in civil state management and bureaucracy in post-Reform Indonesia positioned as both leader in regional political power, while on the other hand they also had the power as the administrator of civil service management and its bureaucracy. This study aims to analyse on the impact of this authority as mandated by the laws in autonomy and regional governance on civil servant management. This is a normative legal research article. The literature review gathers information from document, reference and regulatory analysis. The data analysed qualitatively and presented descriptively. This article sums up that the regional government leader’s political authority created a phenomenon where there are imbalances and dependencies between the relationship of bureaucracy and political power in regional governance. The progress of this governance relationship also showed flaw in bureaucracy, where the bureaucrats and officials are vulnerable into subjective and political issues that might affect the quality of public services performed. The relationship between bureaucrats and regional leaders as political nevertheless created the occurrence of civil servant management laws violations, especially against the merit system and open job promotions. These cases of violations happened in several regional government on different occasions.
Evaluación del desempeño de un aliado estratégico para operación logística
Authors: Urbano Guerrero Luz Carime , Muñoz Marín Luz Stella , Osorio Gómez Juan Carlos 
Published: July 2024

Tan importante como la selección de un proveedor y en este caso particular un aliado estratégico para la operación logística de una compañía (proveedor 3PL), es conocer si efectivamente el desempeño de este aliado está acorde con lo esperado en el proceso de selección. Considerando esta importancia, se propone una metodología para evaluar el desempeño de un proveedor de servicios logísticos. La metodología planteada considera elementos científicos y analíticos para la definición de un conjunto de criterios queincluyen no sólo las características más importantes del servicio de transporte de carga contenerizada, sino también aquellas competencias que pueden afectar el desarrollo y la sostenibilidad de una alianza estratégica. Estos criterios se describen y se les asocian subcriterios e indicadores, con su respectiva frecuencia de medición. Posteriormente, son ponderados utilizando la metodología básica del AHP; y luego todos estos elementos se consignan en un formato diseñado para realizar la valoración final del aliado, a la luz del modelo propuesto.
Hardware-level calibration of the Chitaga Water Cherenkov Detector in the GUANE array for space weather study
Authors: Peña Rodríguez Jesus , Asorey Hernan , Hernández-Barajas S. , León-Carreño F. , Ierra-Porta David , Núñez L. A. 
Published: July 2024

Water Cherenkov Detectors (WCDs) play an essential role in space weather and cosmic rays studies around the world. In this article, we present a general methodology to calibrate a WCD based finding its optimum operation point and counting the delay time of the transmission cables. The dynode charge histogram of the WCD and CORSIKA simulations validate this methodology. Finally, to illustrate the capability of WCD tomeasure fluctuations in the secondary CR flux, we studied the 07.09.2017 Forbush and compared our measurements with data obtained from the Neutron Flux Monitor at UNAM and the Kyoto Dst index service.
Modelo predictivo para la determinación del flujo de descarga en válvulas de alivio de presión en aplicaciones de vapor
Authors: Duarte Forero Jorge Eliécer , Camargo Fiorillo Carlos , García Rincón Carlos 
Published: July 2024

Este artículo presenta el desarrollo de un modelo predictivo para cuantificar el flujo de descarga de vapor enválvulas de seguridad, a partir de ensayos realizados con Nitrógeno en un banco de prueba. El modelo propuesto se construyó con datos experimentales obtenidos a través de mediciones en banco de prueba que cumplen los lineamientos de la normativa ASME/API vigente. Se realizaron simulaciones en la herramienta CFD del software ANSYS®, las cuales fueron validadas con los datos experimentales obtenidos, con el fin deaumentar los puntos de muestreo dentro del rango de operación de las válvulas y de esta forma reducir los costos de experimentación. Estos resultados se relacionaron con las variables que influyen el fenómeno en estudio a través de una regresión multivariable, con lo que se obtuvo una expresión capaz de predecir el flujo de vapor a través de la válvula de seguridad. La correlación propuesta calcula el factor de corrección parapredecir el flujo desalojado por la válvula operando en el generador de vapor, pero basado en la medición del flujo de descarga de Nitrógeno en el banco de prueba. Se validó la reproducibilidad del modelo desarrollado a través de una prueba de Durbin-Watson para residuos, una prueba de hipótesis para el modelo y una prueba de normalidad, en donde se verificó la alta capacidad de predicción de las correlaciones desarrolladas en el presente estudio.