bluuebunny/crossref_metadata_2025_split huggingface dataset:
The possible protective mechanism of Hyperbaric oxygen (HBO) in memory impairments induced by Aβ25–35 in rats
Authors: Tian XiaoQiang , Zhang LiDa , Wang JingMei , Dai JianGuo , Shen ShanShan , Yang Lin , Huang PeiLin 
Published: April 2013

Abstract
Alzheimer’s disease is characterized by the accumulation and deposition of Aβ peptides in human brains. Aβ peptides are toxic to neurons by lots of mechanisms of which Aβ induced oxidative stress is one of the hypothesis. The present study aimed to determine the effect of Hyperbaric oxygen (HBO) on Aβ25–35 induced cognitive deficits and oxidative stress and apoptosis effects in rats. Rats were given an injection of aggregated Aβ25–35. After treatment with HBO for 20days, the learning and memory ability, hippocampus neuronal apoptosis, the activity of SOD, GSH content and the MDA level and mRNA and proteins expression of Bcl-2 and Bax were detected. Our results demonstrated that HBO could significantly improved the apoptosis hippocampus neuronal induced by Aβ25–35, involving the improvement of the learning and memory impairment, which accompanied of increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content. These findings suggest that treatment of HBO might prevent the Aβ25–35 induced learning and memory impairment by increasing the gene and protein expression of bcl-2 and enhancing the activity of SOD and GSH content to alleviate the apoptosis hippocampus neuronal. This suggests that HBO may be a potential therapeutic agent for AD.
Hemothorax after chest tube insertion for pneumothorax as a complication of clopidogrel
Authors: Ohara Gen , Kagohashi Katsunori , Kurishima Koichi , Miyazaki Kunihiko , Satoh Hiroaki 
Published: April 2013

Abstract
Hemorrhagic complications are recognized when anti-platelet agents are used during or after surgical procedures. We present a 69-year-old male patient who developed hemothorax after chest tube insertion for pneumothorax as a complication of clopidogrel and aspirin following ischemic heart disease. Hemothorax associated clopidogrel has rarely been reported and this is the first academic publication of this complication type following chest tube insertion shortly after the cessation of clopidogrel. Our case demonstrates the possibility of hemothorax when chest tube insertion is indicated under such conditions.
Lateral hypothalamic area deep brain stimulation for refractory obesity: a pilot study with preliminary data on safety, body weight, and energy metabolism
Authors: Whiting Donald M. , Tomycz Nestor D. , Bailes Julian , de Jonge Lilian , Lecoultre Virgile , Wilent Bryan , Alcindor Dunbar , Prostko E. Richard , Cheng Boyle C. , Angle Cynthia , Cantella Diane , Whiting Benjamin B. , Mizes J. Scott , Finnis Kirk W. , Ravussin Eric , Oh Michael Y. 
Published: April 2013

Object
Deep brain stimulation (DBS) of the lateral hypothalamic area (LHA) has been suggested as a potential treatment for intractable obesity. The authors present the 2-year safety results as well as early efficacy and metabolic effects in 3 patients undergoing bilateral LHA DBS in the first study of this approach in humans.

Methods
Three patients meeting strict criteria for intractable obesity, including failed bariatric surgery, underwent bilateral implantation of LHA DBS electrodes as part of an institutional review board– and FDA-approved pilot study. The primary focus of the study was safety; however, the authors also received approval to collect data on early efficacy including weight change and energy metabolism.

Results
No serious adverse effects, including detrimental psychological consequences, were observed with continuous LHA DBS after a mean follow-up of 35 months (range 30–39 months). Three-dimensional nonlinear transformation of postoperative imaging superimposed onto brain atlas anatomy was used to confirm and study DBS contact proximity to the LHA. No significant weight loss trends were seen when DBS was programmed using standard settings derived from movement disorder DBS surgery. However, promising weight loss trends have been observed when monopolar DBS stimulation has been applied via specific contacts found to increase the resting metabolic rate measured in a respiratory chamber.

Conclusions
Deep brain stimulation of the LHA may be applied safely to humans with intractable obesity. Early evidence for some weight loss under metabolically optimized settings provides the first “proof of principle” for this novel antiobesity strategy. A larger follow-up study focused on efficacy along with a more rigorous metabolic analysis is planned to further explore the benefits and therapeutic mechanism behind this investigational therapy.
Procollagen Type I C-terminal propeptide, procollagen Type III N-terminal propeptide, hyaluronic acid, and laminin in the cerebrospinal fluid of rats with communicating hydrocephalus
Authors: Xu Hao , Wang Zhanxiang , Zhang Shaolin , Tan Guowei , Zhu Hongwei 
Published: April 2013

Object
Fibrosis along the route of CSF flow is indicated by the development of hydrocephalus. The changes of fibrosis index might reflect the level of hydrocephalus and even become a diagnostic index of hydrocephalus. The object of this study was to analyze the levels of procollagen Type I C-terminal propeptide (PICP), procollagen Type III N-terminal propeptide (PIIINP), hyaluronic acid (HA), and laminin (LN) and their significance in the CSF of communicating hydrocephalus rat models.

Methods
Thirty adult Sprague-Dawley rats were randomly divided into 3 groups: hydrocephalus group (20 rats) with intraventricular kaolin injections, sham control group (5 rats) with saline injections, and normal group (5 rats) without any processing. The levels of PICP, PIIINP, HA, and LN in the CSF were detected using ELISA.

Results
Levels of PICP, PIIINP, HA, and LN in the hydrocephalus group were significantly higher than those in the saline control group (p < 0.05). It was revealed by correlation analysis that the increase was positively correlated with the severity of ventricular dilation.

Conclusions
Results indicated that PICP, PIIINP, HA, and LN continue to rise dramatically in experimental hydrocephalus and may serve as the diagnostic index of hydrocephalus.
Stand und Perspektiven einer landesweiten Baumartenklassifikation mit digitalen Luftbildern
Authors: Waser Lars T. 
Published: April 2013

Status and perspectives of country-wide tree species classification based on digital aerial images
There is an increasing interest on area-wide and high-resolution data of forest composition. In Switzerland, tree species distribution will be considered periodically by the Swiss National Forest Inventory (NFI), but the claims will be only partly fulfilled by the existing forest type maps since they are relatively poor regarding spatial accuracy, updating, and reproducibility. Providing consistent, reproducible and up-to-date information on various forest parameters is the main advantage of using the latest remote sensing data and methods. New possibilities are given by the airborne digital sensor ADS80, which records the entire country during the vegetation season every six years. This paper presents a robust methodology of classifying tree species in different study areas. The obtained accuracies for beech, ash, Norway spruce, Scots pine, larch, willow and silver fir are in average 71–85%, but lower for other deciduous tree species. These are mainly less dominant tree species within a study area such as maple and birch. A small sample data set and shadows of other neighboring trees seem to be the main reasons for this. Based on the experiences made in this study, a country-wide classification of tree species has become more feasible. The usage of airborne digital sensor ADS80 data in combination with a high degree of automation from the developed methods will enable the generation of country-wide products on the distinction of coniferous and deciduous tree species until 2015.
Los saberes en torno a la tuberculosis en Valencia a través de la prensa médica (1882-1914)
Authors: Báguena María-José 
Published: April 2013

Pour la réalisation de ce travail, nous sommes parti de l’intérêt qu’offre l’étude de la littérature scientifique sur la tuberculose à la fin du XIXe siècle et au début du XXe siècle à Valence. Ce sujet est d’une importance capitale non seulement quant à la réalité épidémiologique de l’époque, mais aussi pour la constitution de la science et la pratique médicale contemporaines. L’étude a été abordée à travers les revues médicales qui y sont publiées entre 1882 et 1914, période pendant laquelle l’origine microbienne de la maladie a été découverte et se sont développées de nouvelles techniques de diagnostic, de prévention et de traitement de la tuberculose. Dans les huit revues consultées ont été recensés 602 articles sur cette question ; 37,04 % d’entre eux sont parus dans la Revista de Higiene y Tuberculosis, dont le directeur, José Chabás, a aussi été l’auteur le plus prolifique, avec 31 articles. Les sujets les plus fréquemment abordés sont ceux qui portent sur la découverte du bacille de Koch, la découverte et les applications de la tuberculine ainsi que sur l’organisation de la lutte contre la tuberculose.
La Gazeta de Valencia de 1812
Authors: Dufour Gérard 
Published: April 2013

Conservée à la Biblioteca Valenciana, la collection des numéros de la Gazeta de Valencia publiés en 1812 sous le contrôle du maréchal Suchet apporte de précieux renseignements sur les rapports entre celui-ci et le roi Joseph I. Le prologue, publié le 1 février 1812, un mois après l’entrée des troupes françaises dans Valence, outre les traditionnels renseignements qu’il fournit sur les conditions de souscription, manifeste clairement que le maréchal de l’Empire n’agit qu’au nom de l’Empereur, sans la moindre considération à l’égard de son frère. L’indépendance de Suchet par rapport à Joseph apparaîtra également dans le choix des informations en provenance de Madrid, soigneusement choisies pour ne pas faire ombrage au duc de l’Albufera. Lors de la retraite à Valence du « roi errant » en septembre 1812, la Gazeta… resta sous le contrôle du seul Suchet, même si les propagandistes attitrés de la nouvelle dynastie (Estala, Moratín, Llorente) purent participer à sa rédaction, ce qui n’est avéré que pour Llorente. Faute de pouvoir assurer la diffusion de ce périodique dans le sud de l’ancien royaume de Valence (où Alicante ne fut jamais occupée par l’armée impériale), Suchet parvint en revanche à la faire connaître à Saragosse, comme en témoigne la correspondance de son évêque auxiliaire, Miguel Suárez de Santander publiée dans les pages de la Gazeta qui se présente ainsi comme l’organe de presse officiel de ce vice-royaume de fait que constituaient pour Suchet l’Aragon et Valence.
Presse et propagande pendant la guerre civile espagnole : la participation des femmes du P.O.U.M. dans la guerre des idées (1936-1937)
Authors: Coignard Cindy 
Published: April 2013

On trouvera dans cet article une approche du rôle qu’ont joué les femmes dans la presse du P.O.U.M. depuis le début de la guerre civile espagnole jusqu’au milieu de l’année 1937, moment où le Parti est persécuté, censuré puis déclaré illégal. On se propose donc de voir dans quelle mesure ces femmes ont participé à la tâche propagandistique dans la presse écrite à travers des journaux comme Avançada, L’Espurna, Impuls, Emancipación… et ce, autour de deux axes principaux : d’une part une propagande organisée en fonction des ennemis du mouvement ouvrier (fascisme, capitalisme, stalinisme) ; d’autre part, une propagande interne au P.O.U.M. et plutôt adressée aux femmes du Parti afin de tenter de les mobiliser.
La gravure : un élément clé de l’ambitieuse politique éditoriale de l’Espíritu de los mejores diarios literarios, que se publican en Europa (1787-1791)
Authors: Larriba Elisabel 
Published: April 2013

Cet article, qui porte sur l’Espíritu de los mejores diarios literarios, que se publican en Europa, s’inscrit dans le cadre de l’étude que nous menons sur l’usage de la gravure dans la presse espagnole des Lumières (voir El Argonauta español, n° 2, janvier 2005 et n° 5, janvier 2008). Fondé en 1787 par Cristóbal Cladera, ce périodique (qui rencontra d’emblée un vif succès) fit du recours à l’image un élément clé de son ambitieuse politique éditoriale. Comme nous le verrons, il entendait bien, par cette pratique encore peu usitée en Espagne, affirmer clairement sa différence vis-à-vis de ses concurrents à l’échelle nationale et se mettre au diapason des publications périodiques les plus prestigieuses d’Europe érigées en modèles incontestables.
Parcours journalistiques en régime colonial : José Rossi y Rubí, Alejandro Ramírez et Simón Bergaño
Authors: Poupeney Hart Catherine 
Published: April 2013

Au tournant des XVIIIe et XIXe siècles, trois figures clefs des débuts du journalisme hispano-américain se retrouvent en Amérique centrale (Royaume de Guatemala) : José Rossi y Rubí, co-fondateur du Mercurio peruano, Alejandro Ramírez et Simón Bergaño, tous deux éditeurs de la Gazeta de Guatemala , qui seront plus tard fondateurs du Diario económico de Puerto Rico, pour l'un, et du , pour l'autre. La comparaison des parcours de ces personnages à la fois exceptionnels et exemplaires permet de mieux cerner les modalités de discussion et de diffusion des Lumières en Amérique, ainsi que les conditions d'exercice de la parole publique à la fin du régime colonial.
Trahison, Procès et Conservation : la Gazette « française » d’Oviedo (1810-1811)
Authors: Laspra Alicia 
Published: April 2013

La Gazeta de Oviedo fut publiée pour la première fois dans la capitale des Asturies le 4 juin 1808, étant le résultat d’une des nombreuses initiatives adoptées par la « Junta Suprema » de la province après la rébellion espagnole contre Napoléon. A partir de cette date, au moins 111 numéros furent imprimés par José Díaz Pedregal, l’imprimeur officiel de la Principauté des Asturies. La première invasion de la province par les forces françaises n’entraîna pas la disparition de la Gazeta patriotique qui fut publiée par le même imprimeur jusqu’en janvier 1810. Cependant, la situation changea quand les Français occupèrent la Principauté pour la deuxième fois, et plus longuement, de la fin janvier 1810 à juin 1811. Les autorités asturiennes prirent la fuite mais leur imprimeur demeura dans la capitale, une attitude qui fut par la suite interprétée comme une trahison. Pedregal, en effet, imprima la « nouvelle » Gazette d’Oviedo, utilisée comme un instrument de propagande par l’administration française de la province.Bien que ce périodique au service des Français ait été publié régulièrement pendant six mois, et bien que ses 56 numéros aient fait l’objet d’un tirage considérable, on pensait qu’aucun exemplaire n’avait survécu. Mais une récente et fortuite découverte aux Archives Nationales (AHN, Madrid) a permis de mettre à jour une collection complète de la Gazeta de Oviedo, incluant à la fois les originaux manuscrits et les numéros imprimés. Cette double collection avait été réunie par les autorités espagnoles afin d’apporter la preuve de la prétendue trahison de Pedregal. Un avantage additionnel inhérent à cette découverte est que sur les originaux manuscrits de la gazette figurent nombre de lignes barrées, ce qui suggère la pratique par les autorités françaises d’une espèce d’auto-censure. Cet article a pour objectif de présenter et d’analyser la Gazeta de Oviedo « française » en accordant une attention toute particulière à sa nature propagandiste, la présumée trahison de son imprimeur et la censure à laquelle furent soumis ses textes.
Les libraires et la diffusion de la presse à Madrid à la fin du XVIIIe siècle
Authors: Cavaillon Giomi Joan 
Published: April 2013

Cet article, qui se veut une contribution à l’étude des relations structurelles entre la presse périodique et les livres au XVIIIème siècle, aborde successivement, pour ce qui est de Madrid : le rôle de la presse dans la diffusion des livres par le biais des annonces ; l’état des librairies madrilènes en ce qui concerne le commerce des livres ; les différents centres de production de la presse et sa diffusion par les libraires dans toute la ville.
Complement in Immune and Inflammatory Disorders: Therapeutic Interventions
Authors: Ricklin Daniel , Lambris John D. 
Published: April 2013

Abstract
With the awareness that immune-inflammatory cross-talk is at the heart of many disorders, the desire for novel immunomodulatory strategies in the therapy of such diseases has grown dramatically. As a prime initiator and important modulator of immunological and inflammatory processes, the complement system has emerged as an attractive target for early and upstream intervention in inflammatory diseases and has moved into the spotlight of drug discovery. Although prevalent conditions such as age-related macular degeneration have attracted the most attention, the diverse array of complement-mediated pathologies, with distinct underlying mechanisms, demands a multifaceted arsenal of therapeutic strategies. Fortunately, efforts in recent years have not only introduced the first complement inhibitors to the clinic but also filled the pipelines with promising candidates. With a focus on immunomodulatory strategies, in this review we discuss complement-directed therapeutic concepts and highlight promising candidate molecules.
An Abnormal Bone Lesion of the Scapula in a Collegiate Basketball Player: A Case Report
Authors: O'Brien Matthew S. , Donnell Allison , Miller Jason , Iven Val Gene , Pascale Mark 
Published: April 2013

Objective:To present the case of a bone lesion of the scapula in a collegiate basketball player.Background:A 19-year-old National Collegiate Athletic Association Division I male basketball player presented with pain in the posterior region of the right shoulder. During practice, he was performing a layup when his arm was forced into hyperflexion by a defender. Evaluation revealed a bone lesion involving the scapular spine and base of the acromion.Differential Diagnosis:Acromioclavicular joint sprain, subacromial bursitis, subscapular bursitis, humeral head contusion, acromial fracture.Treatment:The patient was treated for 2 months with therapeutic modalities and rehabilitation exercises. Because of persistent pain and the risk of a pathologic fracture, open surgical biopsy and bone grafting were then undertaken.Uniqueness:Most simple bone cysts affect the proximal humerus and femur, whereas our patient's lesion was in the acromial complex.Conclusions:Athletic trainers should be alert to the unusual possibility of bone cysts, which are usually identified incidentally when radiographs are obtained for other reasons. Most simple bone cysts are asymptomatic, but a pathologic fracture can occur with trauma.
The wind and fire disturbance in Central European mountain spruce forests: the regeneration after four years
Authors: Budzáková Monika , Galvánek Dobromil , Littera Pavol , Šibík Jozef 
Published: April 2013

A strong windstorm in November 2004 resulted in a huge blown-down spruce forest area in the southern part of the Tatra National Park in the Western Carpathians in Slovakia, Central Europe. The aim of this work is to study the vegetation composition of spruce forest at differently managed sites four years after this disturbance. Four study areas were selected for this purpose: (<strong><em>i</em></strong>) an area where the fallen trees were extracted and new seedlings were planted; (<strong><em>ii</em></strong>) an area, which was hit by a forest fire after the extraction; (<strong><em>iii</em></strong>) an area where no active management was applied; (<strong><em>iv</em></strong>) a reference forest unaffected by such disturbance. A total of 100 plots were selected, 25 of each area type. The result of DCA and CCA analyses consistently indicated that after this short period the non-extracted and extracted areas are currently most similar to the reference forest area, while the fire affected area differed. A one-way ANOVA comparing species cover for the different plot sizes indicated some significant differences between the extracted and non-extracted plots. The abundance of certain species commonly occurring in spruce forests, such as <em>Dyopteris carthusiana</em> agg., <em>Vaccinium myrtillus</em> and <em>Avenella flexuosa</em>, correlated weli with the non-extracted plots, compared to the extracted plots. Coverage of these species was lowest on burned plots. The lowest Shannon-Wiener’s diversity values were recorded in burned plots. This was most likely a consequence of mono-dominant competitive species spread, (mainly <em>Chamerion angustifolium</em>) which profited from the altered ecological conditions following the fire. Although some differences were also registered in the Shannon-Wiener diversity index between the remaining research plots, however these were not statistically significant. The most important results of our investigations include the extensive influence of fire disturbance on vegetation. Study revealed that the wind-disturbed area is able to regenerate sufficiently without human intervention.
Determinants of medium and high VACS index in HIV‐positive patients on effective HAART
Authors: Suardi E , Gazzola L , Cicconi P , Grillo E , Bini T , Marchetti G , d'Arminio Monforte A 
Published: April 2013

Non‐AIDS events are the leading cause of death in HIV‐positive patients (pts) on effective HAART. The VACS index, composed by HIV‐RNA, CD4+, age, hemoglobin, FIB‐4, eGFR and HCV co‐infection, has been validated as 5‐year mortality index in HIV‐ positive pts [1]. The aim of our study was to evaluate the prevalence and any possible predictive factors of medium‐high VACS index in a cohort of HIV‐positive pts; we also evaluated whether it relates with markers of systemic immune activation. 501 consecutive HIV‐positive asymptomatic pts on effective HAART (HIV‐RNA <40 cp/ml) were enrolled. T‐cell activation (CD38+, CD8+45R0, CD8+38R0) and differentiation (CD127+) was assessed by flow cytometry; VACS index was calculated closest to the sample timepoint. Comparisons were assessed by Chi‐square test. Factors associated with VACS index equal or greater than 10% (gender, time on HAART, CD4+nadir, AIDS diagnosis, previous or current IDU, immune‐activation markers) in univariate model entered the multivariate logistic regression. Of the 501 patients enrolled, 350 (70%) had a low VACS index (VACS <10%), 143 (28%) a medium index (VACS 10–30%) and 8 (1%) an high one (VACS >30%). Groups (pts with low and medium‐high VACS index) were comparable for CD4+ nadir, AIDS diagnosis, CD8+45RO%, CD8+38RO%, CD127+%. Females, active or previous IDU, pts with shorter HAART exposure showed more frequently medium‐high VACS index (table 1). In the multivariable model, female sex (AOR 6.26, 95% CI 3.45‐11.38, p<0.000), IDU history (AOR 2.409, 95% CI 1.31–4.422, p=0.0045) and current CD38+/CD8% (each% more: AOR 1.122, 95% CI 1.03‐1.21, p=0.004) were all independent predictors of VACS ≥10%. Our data suggest that a persistently‐activated immune profile despite virologically‐suppressive HAART may contribute to all‐cause mortality risk, possibly through its role in accelerating degenerative disease. Possible determinants of gender differences in VACS index (such as hemoglobin) need to be further studied.

Variable associated with medium‐high VACS index in univariate model

Pts with low (<10%) VACS index (n=350)
Pts with medium‐high (>10%) VACS index (n=151)
p

Female sex °
69 (19%)
66 (43%)
0.0001

AIDS°
75 (21%)
50 (33%)
0.38

Nadir CD4+ T cells/mmc*
211 (7–600)
183 (4–489)
0.75

HAART duration, years*
8.1 (1–21)
7.9 (1–20)
0.01

IDU°
74 (21%)
50 (33%)
0.004

CD127/CD4 + %*
35 (0–63)
35 (0–58)
0.81

CD127/CD8 + %*
44 (0–55)
45 (0–46)
0.70

CD8 + 45/RO%*
13 (0–43)
14 (0–61)
0.7

CD8 + 38/RO%*
1,5 (0–27)
1,6 (0–13)
0.85

CD8 + CD38 + %*
3.01 (0–23)
4.09 (0–23)
0.004

Data are presented as mean (range)
Data are presented as the number (percentage)