bluuebunny/crossref_metadata_2025_split huggingface dataset:
Peran Damkar Dalam Pelayanan Kepada Masyarakat
Authors: Siahaan Rumiris , Purba Rakhmawati , Batubara Rizki Wulanita , Marpaung Josua , Sofyan Mhd. Hafiq , Fahlevi Mhd. Aswad , Pradytia Adji Arifanda , Afifi Dinda Nora Putri , Nainggolan Pinondang 
Published: August 2024

Fire is a disaster that can result in huge losses and these fire disasters often occur in the middle of residential areas regardless of time, status or even distance. The city of Tebing Tinggi is prone to fire disasters, with fires almost every month. Internship is a student activity given in the final semester of study. Useful for training students to know the world of work. Placing internship students in the Fire Department is useful so that they can help communities experiencing disasters by going through the preparation, implementation and evaluation stages. The results of this internship provide benefits for both the campus and the Tebing Tinggi city fire department. There is good cooperation between the two institutions.
EFL Teachers’ Roles in Technology-Integrated Instruction Practices at Junior High School
Authors: Nabilah Nada , Siregar Aisyah , Jayanti Suci Etri 
Published: August 2024

These days, technology-based learning is essential since it provides media and tools for the process of teaching and learning. However, in addition to all of the effort that teachers put into integrating technology into the classroom, other factors must be taken into consideration, one of which is the teacher's role. The purpose of this study was to find out the efficacy of the roles and digital learning resources that English teachers employ in their classes. The responders to this study were 5 English teachers from various junior high schools in Tebing Tinggi, North Sumatera, in the academic year 2022/2023. In addition, 9 students from each class also involved as the respondents. So the total number of students that participated in this study was 45. A qualitative approach was taken in conducting this study. The researcher used interviews and observation as instruments to get the data required for this study. The results of this study showed that teachers additionally played the roles that were necessary for technology-based learning, including as the operators, mentors for technology use, organizers of technology-based learning, and monitors of digital learning.
Pemanfaatan Digital Marketing Pada UMKM Dalam Meningkatkan Penjualan pada Kelurahan Tebing Tinggi Kecamatan Padang Hilir Kota Tebing Tinggi
Authors: Syafrizal Rodi , Nursaimatussaddiya Nursaimatussaddiya , Sianipar Christin Natalia , Sarwoto Sarwoto 
Published: August 2024

This community service activity emphasizes increasing MSME sales through the use of digital marketing, especially for tofu entrepreneurs. The aim of this activity is marketing training using Digital Marketing by providing skills that can increase family income thereby increasing welfare. The aim of this Community Service Activity is to develop MSMEs (Micro, Small and Medium Enterprises) and creative industries in the Tebing Tinggi sub-district community. Especially for jangek cracker products through Digital Marketing training.
Pneumotórax Catamenial – Um Relato de Caso
Authors: Sousa da Silva Romulo , Pedro Henrique Nascimento Mattos  , Letícia Rocha Moreira  , Gustavo Del Campo Cordeiro  , Pedro Augusto Rizzo Egger  , Maria Fernanda Inocente Messias Pinheiro  , Tiago da Rocha Araújo  , Mirelly Alves Vitor  , Rithiele Souza Silva  , Marcos Vinícius Almeida Santos  , Davi Balica de Oliveira  , Beatriz de Castro Barbosa dos Santos  , Ana Carolina Bezerra Góes  , Wesley Soares Pires  , Vanessa Hallich França da Silva  
Published: August 2024

O pneumotórax catamenial é uma entidade clínica rara, que se caracteriza pela ocorrência de pneumotórax espontâneo em mulheres durante o período menstrual, geralmente até dois dias após o início da menstruação Acredita-se que essa condição esteja associada à endometriose torácica, que é uma forma de endometriose que afeta o diafragma, alcançando assim a cavidade torácica. Clinicamente, o pneumotórax catamenial manifesta-se com os sintomas padrão de pneumotórax, incluindo dor torácica súbita, dispneia e, em certas situações, tosse Com base na ligação temporal com o ciclo menstrual, a suspeita diagnóstica é verificada por exames de imagem, como tomografia computadorizada, radiografia de tórax, e, em certos casos, por toracoscopia, que permite a visualização direta das lesões endometrióticas. O manejo do pneumotórax catamenial é um desafio para o profissional médico, pois deve-se de forma simultânea a causa base do quadro. Ou seja, faz-se imperativo um tratamento concomitante da endometriose Para tal, tratamentos hormonais, como os anticoncepcionais orais, têm sido utilizados para suprimir a menstruação e, como resultado, prevenir a recorrência Diante da refratariedade, a opção cirúrgica pode ser necessária para restaurar o diafragma e excisar as lesões endometrióticas. O pneumotórax catamenial é raro e, portanto, requer um alto índice de suspeição clínica, especialmente em mulheres em idade reprodutiva que apresentam pneumotórax recorrente sem explicação aparente Por isso, o seu diagnóstico pode passar despercebido. Compreender essa condição é essencial para formular planos de tratamento eficazes e melhorar a qualidade de vida dessas pacientes.
Instructional Observation of Positive Teacher Behavior Assessment Strategy in Elementary Classroom Activities
Authors: Stevani Margaret 
Published: August 2024

Background. This study examined how positive teachers' behavior impacted young learners' engagement in elementary school.
It focused on two main aspects: how well young learners followed instructions and how teachers delivered clear instructions during classroom activities.
Purpose. The central question was whether observing positive teachers’ behaviors during instruction could boost young learners' participation.Using a descriptive qualitative approach, this research analyzed the structure of positive instructions, including direct commands, questions, statements, and clarification requests through observation and recording. This research involved 8 teachers from an International Elementary School in North Sumatra and 24 young learners.
Method. To ensure the reliability of the findings, this research used content validity and inter-rater reliability. The results provided a specific measure for evaluating elementary teachers' instructional practices through observation. It highlighted their abilities to manage classroom transitions and provide clear guidance to young learners during activities that can positively impact their academic motivation.
Results. This research conclude the constructive instruction of teachers in lesson teaching by combining social, communication, and emotional regulation skills through by calculating young learners' participation scores.
Gas Chromatography – Mass Spectrometry Analysis and in Silico Antimalarial Activity Studies of Compounds from Leaves Extracts of Mitragyna inermis (Willd.) Kuntze
Authors: Olalubi Oluwasogo A. , Ajiboye Abdulfatai T. , Abdulameed Hassan T, , Kamal Nik Nur Syazni Nik Mohamed 
Published: August 2024

Background: Malaria remains the deadliest infectious diseases in many tropical and subtropical regions, including Nigeria and other West African countries where its transmission occurs all year round. In many inhabitants, medicinal plants are traditionally used as remedies against the symptoms of acute malaria because of their efficacious properties demonstrated by their phytoconstituents. Mitragyna inermis is one of the medicinal plants used by traditional healers in Nigeria for the treatment of various human diseases including malaria.
Methods: We identified the phytochemical constituents of the methanol leaves extract of M. Inermis using gas chromatography-mass spectrometry (GC-MS) technique. Furthermore, the in silico antimalarial study was conducted by investigating the binding interactions of the identified compounds with plasmepsin II, a key enzyme implicated in malaria pathogenesis using EH58 reference ligand by employing molecular docking techniques.
Results: A total number of 40 compounds were identified from the extract of M.inermis, and cis-13,16-docasadienoic acid (12. 33 %) was identified as the major phytochemical. Other phytochemicals like Pyrrolo[1,2-a] pyazine-1,4-dione, hexahydro-3-(methylpropyl), 3-benzyl-6-methyl-2,5-piperazinedione, 2,5 dibenzyloxynitrobenzene, carbonic acid, 2-dimethylaminoethyl neopentyl ester were found but in trace amounts. The results of molecular docking studies predicted interactions of compounds from M. inermis with plasmepsin II enzyme. Five top-scoring bioactive compounds were selected based on their binding energies (docking scores) upon docking with target protein, with compound 2, (2,5-dibenzyloxynitrobenzene) exhibiting the best binding affinity. ADME properties indicated favorable drug-like characteristics for these compounds, while toxicity predictions showed hepatotoxicity and immunotoxicity. Pharmacokinetic assessments revealed high gastrointestinal absorption, blood-brain barrier permeability for compound 2, and inhibition potential against CYP enzymes for certain compounds, offering insights into their therapeutic potential against malaria.
Conclusion: The molecular docking analysis revealed the potential of phytochemicals from M. inermis to interact effectively with plasmepsin II enzyme, showing promising antimalarial potentials. The identified compounds exhibited favorable drug-like properties and minimal toxicity concerns, highlighting their potential as candidates for further exploration in the development of antimalarial agents.
A strategy for representing the effects of convective momentum transport in multiscale models: Evaluation using a new superparameterized version of the Weather Research and Forecast model (SP‐WRF)
Authors: Tulich S. N. 
Published: June 2015

AbstractThis paper describes a general method for the treatment of convective momentum transport (CMT) in large‐scale dynamical solvers that use a cyclic, two‐dimensional (2‐D) cloud‐resolving model (CRM) as a “superparameterization” of convective‐system‐scale processes. The approach is similar in concept to traditional parameterizations of CMT, but with the distinction that both the scalar transport and diagnostic pressure gradient force are calculated using information provided by the 2‐D CRM. No assumptions are therefore made concerning the role of convection‐induced pressure gradient forces in producing up or down‐gradient CMT. The proposed method is evaluated using a new superparameterized version of the Weather Research and Forecast model (SP‐WRF) that is described herein for the first time. Results show that the net effect of the formulation is to modestly reduce the overall strength of the large‐scale circulation, via “cumulus friction.” This statement holds true for idealized simulations of two types of mesoscale convective systems, a squall line, and a tropical cyclone, in addition to real‐world global simulations of seasonal (1 June to 31 August) climate. In the case of the latter, inclusion of the formulation is found to improve the depiction of key synoptic modes of tropical wave variability, in addition to some aspects of the simulated time‐mean climate. The choice of CRM orientation is also found to importantly affect the simulated time‐mean climate, apparently due to changes in the explicit representation of wide‐spread shallow convective regions.
Temporal stability and origin of chemoclines in the deep hypersaline anoxic Urania basin
Authors: Goldhammer Tobias , Schwärzle Andreas , Aiello Ivano W. , Zabel Matthias 
Published: June 2015

AbstractSubmarine brine lakes feature sharp and persistent concentration gradients between seawater and brine, though these should be smoothed out by free diffusion in open ocean settings. The anoxic Urania basin of the eastern Mediterranean contains an ultrasulfidic, hypersaline brine of Messinian origin above a thick layer of suspended sediments. With a dual modeling approach we reconstruct its contemporary stratification by geochemical solute transport fundamentals and show that thermal convection is required to maintain mixing in the brine and mud layer. The origin of the Urania basin stratification was dated to 1650 years B.P., which may be linked to a major earthquake in the region. The persistence of the chemoclines may be key to the development of diverse and specialized microbial communities. Ongoing thermal convection in the fluid mud layer may have important yet unresolved consequences for sedimentological and geochemical processes, also in similar environments.
Evaluation of the Argo network using statistical space‐time scales derived from satellite altimetry data
Authors: Kuragano Tsurane , Fujii Yosuke , Kamachi Masafumi 
Published: June 2015

AbstractThis study evaluates capability of the Argo observation network for monitoring ocean variation, especially for eddy‐scale variation, by using an optimum interpolation (OI) procedure. Sea surface dynamic height anomalies (DHAs) are derived from Argo temperature and salinity profile data, and DHA fields are obtained by the OI based on the space‐time correlation scales estimated from along‐track sea level anomaly (SLA) data by satellite altimetry. The DHA fields are compared with the SLA fields derived from the same OI applied to the along‐track SLA data. The results show that the equatorial Kelvin waves and tropical instability waves are well captured by Argo floats. Eddies are also monitored effectively in the subtropical western North Pacific. The OI results of DHA do not agree well with those of SLA in the high latitudes. A simple test of the space‐time OI analysis shows that more than six data in the e‐folding domain, where the correlation coefficient of ocean variation is above e−1, are required for the reliable analysis with 99% confidence level. Argo floats provide sufficient number of observations for the reliable analysis in the low latitudes and some areas in the North Pacific. Two to three times more Argo data would be required in most of midlatitudes and much more in high latitudes for capturing eddy‐scale variation.
Self‐(Un)rolling Biopolymer Microstructures: Rings, Tubules, and Helical Tubules from the Same Material
Authors: Ye Chunhong , Nikolov Svetoslav V. , Calabrese Rossella , Dindar Amir , Alexeev Alexander , Kippelen Bernard , Kaplan David L. , Tsukruk Vladimir V. 
Published: June 2015

AbstractWe have demonstrated the facile formation of reversible and fast self‐rolling biopolymer microstructures from sandwiched active–passive, silk‐on‐silk materials. Both experimental and modeling results confirmed that the shape of individual sheets effectively controls biaxial stresses within these sheets, which can self‐roll into distinct 3D structures including microscopic rings, tubules, and helical tubules. This is a unique example of tailoring self‐rolled 3D geometries through shape design without changing the inner morphology of active bimorph biomaterials. In contrast to traditional organic‐soluble synthetic materials, we utilized a biocompatible and biodegradable biopolymer that underwent a facile aqueous layer‐by‐layer (LbL) assembly process for the fabrication of 2D films. The resulting films can undergo reversible pH‐triggered rolling/unrolling, with a variety of 3D structures forming from biopolymer structures that have identical morphology and composition.
Transition‐Metal‐Mediated Cleavage of a SiSi Double Bond
Authors: Hickox Hunter P. , Wang Yuzhong , Xie Yaoming , Chen Mingwei , Wei Pingrong , Schaefer Henry F. , Robinson Gregory H. 
Published: June 2015

AbstractReaction of carbene‐stabilized disilicon (1) with Fe(CO)5gives the 1:1 adduct L:SiSi[Fe(CO)4]:L (L:=C{N(2,6‐Pri2C6H3)CH}2) (2) at room temperature. At raised temperature, however,2may react with another equivalent of Fe(CO)5to give L:Si[μ‐Fe2(CO)6](μ‐CO)Si:L (3) through insertion of both CO and Fe2(CO)6into the Si2core, which represents the first experimental realization of transition metal‐carbonyl‐mediated cleavage of a SiSi double bond. The structures and bonding of both2and3have been investigated by spectroscopic, crystallographic, and computational methods.
Involvement of Long‐Lived Intermediate States in the Complex Folding Pathway of the Human Telomeric G‐Quadruplex
Authors: Bessi Irene , Jonker Hendrik R. A. , Richter Christian , Schwalbe Harald 
Published: June 2015

AbstractThe energy landscapes of human telomeric G‐quadruplexes are complex, and their folding pathways have remained largely unexplored. By using real‐time NMR spectroscopy, we investigated the K+‐induced folding of the human telomeric DNA sequence 5′‐TTGGG(TTAGGG)3A‐3′. Three long‐lived states were detected during folding: a major conformation (hybrid‐1), a previously structurally uncharacterized minor conformation (hybrid‐2), and a partially unfolded state. The minor hybrid‐2 conformation is formed faster than the more stable hybrid‐1 conformation. Equilibration of the two states is slow and proceeds via a partially unfolded intermediate state, which can be described as an ensemble of hairpin‐like structures.
Optical Absorption and Magnetic Field Effect Based Imaging of Transient Radicals
Authors: Beardmore Joshua P. , Antill Lewis M. , Woodward Jonathan R. 
Published: June 2015

AbstractShort‐lived radicals generated in the photoexcitation of flavin adenine dinucleotide (FAD) in aqueous solution at low pH are detected with high sensitivity and spatial resolution using a newly developed transient optical absorption detection (TOAD) imaging microscope. Radicals can be studied under both flash photolysis and continuous irradiation conditions, providing a means of directly probing potential biological magnetoreception within sub‐cellular structures. Direct spatial imaging of magnetic field effects (MFEs) by magnetic intensity modulation (MIM) imaging is demonstrated along with transfer and inversion of the magnetic field sensitivity of the flavin semiquinone radical concentration to that of the ground state of the flavin under strongly pumped reaction cycling conditions. A low field effect (LFE) on the flavin semiquinone–adenine radical pair is resolved for the first time, with important implications for biological magnetoreception through the radical pair mechanism.
PBPK modeling of irbesartan: incorporation of hepatic uptake
Authors: Chapy Helene , Klieber Sylvie , Brun Priscilla , Gerbal‐Chaloin Sabine , Boulenc Xavier , Nicolas Olivier 
Published: June 2015

AbstractPhysiological based pharmacokinetic (PBPK) modeling is now commonly used in drug development to integrate human or animal physiological data in order to predict pharmacokinetic profiles. The aim of this work was to construct and refine a PBPK model of irbesartan taking into account its active uptake via OATP1B1/B3 in order to predict more accurately its pharmacokinetic profile using Simcyp®. The activity and expression of the human hepatocyte transporters OATP1B1 and OATP1B3 were studied. The relative activity factors (RAFs) for OATP1B1 and OATP1B3 transporters were calculated from intrinsic clearances obtained by concentration dependent uptake experiments in human hepatocytes and HEK overexpressing cells: RAF1B1 using estrone‐3‐sulfate and pitavastatine clearances, and RAF1B3 using cholecystokinine octapeptide (CCK‐8) clearances. The relative expression factor (REF) was calculated by comparing immunoblotting of hepatocytes (REFHH) or tissues (REFtissue) with those of overexpressing HEK cells for each transporter. These scaling factors were applied in a PBPK model of irbesartan using the Simcyp® simulator. Pharmacokinetic simulation using REFHH (1.82 for OATP1B1, 8.03 for OATP1B3) as an extrapolation factor was the closest to the human clinical pharmacokinetic profile of irbesartan. These investigations show the importance of integrating the contribution of the active uptake of a drug in the liver to improve PBPK modeling. Copyright © 2015 John Wiley & Sons, Ltd.
Preliminary Design of a Vacuum Pressure Swing Adsorption Process for Natural Gas Upgrading Based on Amino‐Functionalized MIL‐53
Authors: Serra‐Crespo Pablo , Wezendonk Tim A. , Bach‐Samario Carlos , Sundar Nishanth , Verouden Karlijn , Zweemer Matthijs , Gascon Jorge , Berg Henk van den , Kapteijn Freek 
Published: June 2015

AbstractA preliminary study based on a conceptual process design methodology that includes a technical evaluation and an economic study has been carried out for the use of the metal‐organic framework NH2‐MIL‐53(Al) as adsorbent for the separation of carbon dioxide from methane. Among the alternatives considered, a vacuum pressure swing adsorption was chosen in the detailed design phase. The combination of a design with columns in parallel and the possibility of recirculating some of the streams ensures a high degree of separation and a final product with high quality without compromising the operation costs. A comparison with the state‐of‐the‐art technology, amine scrubbing, and with a process based on membranes demonstrates that the proposed process is competitive as a result of its low operation costs and the energy demand.
Late‐Stage Peptide Diversification by Bioorthogonal Catalytic CH Arylation at 23 °C in H2O
Authors: Zhu Yingjun , Bauer Michaela , Ackermann Lutz 
Published: June 2015

AbstractThe step‐economical late‐stage diversification of tryptophan‐containing peptides was accomplished through chemo‐ and site‐selective palladium‐catalyzed CH arylation under exceedingly mild reaction conditions. Thus, the CH functionalization occurred efficiently at 23 °C with a catalyst loading as low as 0.5 mol %, and/or in H2O.
Group 9 Metal Complexes of meso‐Aryl‐Substituted Rubyrin
Authors: Soya Takanori , Osuka Atsuhiro 
Published: June 2015

AbstractInvited for the cover of this issue are Takanori Soya and Atsuhiro Osuka at Kyoto University. The image depicts Group 9 metal (Co, Rh, and Ir) complexes of meso‐aryl‐substituted rubyrin and a meteorite approaching to the atmosphere. A large amount of Iridium is often contained in meteorites. Read the full text of the article at 10.1002/chem.201501080.
Effects of Aromatic Stabilization Energies on Photochromism of New Asymmetrical Azaindole‐Containing Diarylethenes
Authors: Sun Zhiyuan , Zhang Congcong , Li Hui , Fan Congbin , Liu Gang , Pu Shouzhi 
Published: June 2015

AbstractThree new asymmetrical diarylethenes containing an azaindole moiety and a variable heteroaryl ring have been synthesized. Their properties, such as photochromism, fatigue resistance, thermal stability, acidichromism, and fluorescence, were systematically investigated to elucidate the effects of aromatic stabilization energies (ASE) of the heteroaryl moieties. The results indicated that thermal stability decreased with the increment of the aromatic stabilization energies of the variable heteroaryl rings in the order of thiazyl<thienyl<pyrrolyl. Moreover, the dual switching behaviors of these azaindole‐containing diarylethenes were also studied by the stimulation of acid/base and light. Addition of trifluoroacetic acid to the solutions of these diarylethenes resulted in obvious hypochromic shifts, and their N‐protonated forms also exhibited favorable photochromism.