bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibition of Cell Adhesion by a Cadherin-11 Antibody Thwarts Bone Metastasis
Authors: Lee Yu-Chen , Bilen Mehmet Asim , Yu Guoyu , Lin Song-Chang , Huang Chih-Fen , Ortiz Angelica , Cho Hyojin , Song Jian H. , Satcher Robert L. , Kuang Jian , Gallick Gary E. , Yu-Lee Li-Yuan , Huang Wilber , Lin Sue-Hwa 
Published: August 2013

Abstract
Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells. However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin. Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis. These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis. To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11. Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11–mediated cell–cell aggregation in vitro using L-cells transfected with cadherin-11. Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively. Furthermore, mAb 2C7 inhibited cadherin-11–mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts. Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell–cell adhesion. Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model. These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells.
Implications: Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases. Mol Cancer Res; 11(11); 1401–11. ©2013 AACR.
Prosthesis-Patient Mismatch in Bovine Pericardial Aortic Valves
Authors: Chacko Satish Jacob , Ansari Asimul H. , McCarthy Patrick M. , Malaisrie S. Chris , Andrei Adin-Cristian , Li Zhi , Lee Richard , McGee Edwin , Bonow Robert O. , Puthumana Jyothy J. 
Published: August 2013

Background—
The prevalence of prosthesis-patient mismatch (PPM) and its impact on survival after aortic valve replacement have not been clearly defined. Historically, the presence of PPM was identified from postoperative echocardiograms or preoperative manufacturer-provided charts, resulting in wide discrepancies. The 2009 American Society of Echocardiography (ASE) guidelines proposed an algorithmic approach to calculate PPM. This study compared PPM prevalence and its impact on survival using 3 modalities: (1) the ASE guidelines–suggested algorithm (ASE PPM); (2) the manufacturer-provided charts (M PPM); and (3) the echocardiographically measured, body surface area–indexed, effective orifice area (EOAi PPM) measurement.

Methods and Results—

A total of 614 patients underwent aortic valve replacement with bovine pericardial valves from 2004 to 2009 and had normal preoperative systolic function. EOAi PPM was severe if EOAi was ≤0.60 cm
2
/m
2
, moderate if EOAi was 0.60 to 0.85 cm
2
/m
2
, and absent (none) if EOAi was ≥0.85 cm
2
/m
2
. ASE PPM was severe in 22 (3.6%), moderate in 6 (1%), and absent (none) in 586 (95.4%). ASE PPM was similar to manufacturer-provided PPM (
P
=1.00). ASE PPM differed significantly from EOAi PPM (
P
<0.001), which identified severe mismatch in 170 (29.7%), moderate in 191 (33.4%), and absent (none) in 211 patients (36.9%). Irrespective of the PPM classification method, PPM did not adversely affect midterm survival (average follow-up, 4.1±1.8 years; median, 3.9 years; range, 0.01–8 years). There were no reoperations for PPM.

Conclusions—
In patients with normal systolic function undergoing bovine pericardial aortic valve replacement, the prevalence of PPM using the algorithmic-ASE approach was low and correlated well with manufacturer-provided PPM. Independent of the method of PPM assessment, PPM was not associated with medium-term mortality.
Quantification of Cardiomyocyte Hypertrophy by Cardiac Magnetic Resonance
Authors: Coelho-Filho Otavio R. , Shah Ravi V. , Mitchell Richard , Neilan Tomas G. , Moreno Heitor , Simonson Bridget , Kwong Raymond , Rosenzweig Anthony , Das Saumya , Jerosch-Herold Michael 
Published: August 2013

Background—
Cardiomyocyte hypertrophy is a critical precursor to the development of heart failure. Methods to phenotype cellular hypertrophy noninvasively are limited. The goal was to validate a cardiac magnetic resonance–based approach for the combined assessment of extracellular matrix expansion and cardiomyocyte hypertrophy.

Methods and Results—

Two murine models of hypertension (n=18, with n=15 controls) induced by
l
-
N
G
-nitroarginine methyl ester (L-NAME) and pressure overload (n=11) from transaortic constriction (TAC) were imaged by cardiac magnetic resonance at baseline and 7 weeks after L-NAME treatment or up to 7 weeks after TAC. T1 relaxation times were measured before and after gadolinium contrast. The intracellular lifetime of water (
τ

ic

), a cell size–dependent parameter, and extracellular volume fraction, a marker of interstitial fibrosis, were determined with a model for transcytolemmal water exchange. Cardiomyocyte diameter and length were measured on FITC–wheat germ agglutinin–stained sections. The τ
ic
correlated strongly with histological cardiomyocyte volume-to-surface ratio (
r
=0.78,
P
<0.001) and cell volume (
r
=0.75,
P
<0.001). Histological cardiomyocyte diameters and cell volumes were higher in mice treated with L-NAME compared with controls (
P
<0.001). In the TAC model, cardiac magnetic resonance and histology showed cell hypertrophy at 2 weeks after TAC without significant fibrosis at this early time point. Mice exposed to TAC demonstrated a significant, longitudinal, and parallel increase in histological cell volume, volume-to-surface ratio, and τ
ic
between 2 and 7 weeks after TAC.

Conclusion—

The τ
ic
measured by contrast-enhanced cardiac magnetic resonance provides a noninvasive measure of cardiomyocyte hypertrophy. Extracellular volume fraction and τ
ic
can track myocardial tissue remodeling from pressure overload.
Natural History and Prognostic Value of Corticospinal Tract Wallerian Degeneration in Intracerebral Hemorrhage
Authors: Venkatasubramanian Chitra , Kleinman Jonathan T. , Fischbein Nancy J. , Olivot Jean‐Marc , Gean Alisa D. , Eyngorn Irina , Snider Ryan W. , Mlynash Michael , Wijman Christine A. C. 
Published: August 2013

Background

The purpose of this study was to define the incidence, imaging characteristics, natural history, and prognostic implication of corticospinal tract Wallerian degeneration (
CST
‐
WD
) in spontaneous intracerebral hemorrhage (
ICH
) using serial
MR
imaging.

Methods and Results

Consecutive
ICH
patients with supratentorial
ICH
prospectively underwent serial
MRI
s at 2, 7, 14, and 21 days.
MRI
s were analyzed by independent raters for the presence and topographical distribution of
CST
‐
WD
on diffusion‐weighted imaging (
DWI
). Baseline demographics, hematoma characteristics,
ICH
score, and admission National Institute of Health Stroke Score (
NIHSS
) were systematically recorded. Functional outcome at 3 months was assessed by the modified Rankin Scale (
mRS
) and the motor‐
NIHSS
. Twenty‐seven patients underwent 93
MRI
s; 88 of these were serially obtained in the first month. In 13 patients (48%), all with deep
ICH
,
CST
‐
WD
changes were observed after a median of 7 days (interquartile range, 7 to 8) as reduced diffusion on
DWI
and progressed rostrocaudally along the
CST
.
CST
‐
WD
changes evolved into T
2
‐hyperintense areas after a median of 11 days (interquartile range, 6 to 14) and became atrophic on
MRI
s obtained after 3 months. In univariate analyses, the presence of
CST
‐
WD
was associated with poor functional outcome (ie,
mRS
4 to 6;
P
=0.046) and worse motor‐
NIHSS
(5 versus 1,
P
=0.001) at 3 months.

Conclusions

Wallerian degeneration along the
CST
is common in spontaneous supratentorial
ICH
, particularly in deep
ICH
. It can be detected 1 week after
ICH
on
DWI
and progresses rostrocaudally along the
CST
over time. The presence of
CST
‐
WD
is associated with poor motor and functional recovery after
ICH
.
An Evaluation of Jürgen Moltmann’s Concept of Time and Space in the New Creation
Authors: Hausoul Raymond R. 
Published: August 2013

Abstract
This article concentrates on Jürgen Moltmann’s elaboration of time and space, which constitute a hermeneutical key when talking about the new creation. It presents a general survey of Moltmann’s concept of time and space, and critically evaluates the doctrine of zimzum, the dialectic of time and eternity, and the view on limited and omnipresent space which influences Moltmann’s view on the new creation. In my approach I argue extensively that the time and space of creation will not change into the infinite free time and space of God, but they will border on it, and thereby be connected and separated by it.
Do Consumers Have the Right to Drink Healthy Wine?An Appraisal of the Deutsches Weintor Case
Authors: Inglese Marco 
Published: August 2013

Abstract
This article seeks to appraise the development that the Deutsches Weintor case will bring to EU law concerning health protection. The analysis will be carried out by highlighting the structure and the aims of Regulation no. 1924/2006/EC in order to assess its role in the construction of health as a fundamental right. Furthermore, attention will be devoted to how this judgment could affect the general theory behind fundamental rights and how it is placed in relation to the settled case law of the Court.
Beyond Universality and Particularity: The Problem of the Human Rights Language in Liberation Theology
Authors: Adiprasetya Joas 
Published: August 2013

Abstract
This comment demonstrates the changes of attitude among liberation theologians toward human rights language, from avoidance, through critical confrontation, to appropriation. The reluctance appears as a natural consequence of the idea of partiality and preferentiality held by liberationists, which has always been critical of any claim of universality such as human right. The comment also argues that the latest phase of appropriation is made possible after liberationists employ the ecclesial idea of the ‘preferential option for the poor.’ However, the acceptance of human rights language can only be possible if we see the poor as concrete universal and understand the idea of the ‘preferential option for the poor’ as a middle axiom.
Universal Rights versus Sharia? Reflections on the Moral and Legal Dimensions of Human Rights Law and Sharia
Authors: Namli Elena 
Published: August 2013

Abstract
This article develops a critique of the monopoly of liberal ideology in the field of human rights by considering how law, morality and politics are related to each other. The author argues that the constructive potential of international human rights law does not lie in its being understood and practiced as a positive law. On the contrary, to focus on human rights law as positive law is to conceal the political nature of human rights and to prevent effective development of its moral and political potential. Further, the author considers the case of Sharia law and argues that Sharia, for it to be implemented concretely in the social, political, and legal spheres, must be understood as a moral and religious ‘way’. These interpretations of human rights law and Sharia are used as the basis for a critique of the idea that human rights law and Sharia contradict each other.
Imagined, Transcultural, and Colonial Spaces in Print: Newspaper Serialization of Translated Novels in Colonial Korea
Authors: Cho Heekyoung 
Published: August 2013

Abstract
This essay analyzes the Korean ‘relay translation’ of a Japanese adaptation of an English popular novel, entitled Chŏngbuwŏn (A virtuous woman’s resentment) in Korean, which was serialized in a daily newspaper in the mid-1910s. In tandem with the English source text and the Japanese translation, the meaning of the Korean translation was overdetermined by advertisements for the translation, the translator’s preface and footnotes, the readers’ responses, and the serialized novel’s physical coexistence with news carried in the same visual space. Using the prism of space (both tangible and imagined) as a pivot, I argue that the publication of serialized translations of novels in newspapers was situated on the cultural front-line that confronted and negotiated the diverse constructive forces that shaped modern Korean literature. This form of publication thus highlights the characteristics of literature as process, a view that reinstates such seemingly incomplete writings and translations as authentic and legitimate cultural (literary) constituents in modern Korea.
Topological Entropy: A Lagrangian Measure of the State of the Free Atmosphere
Authors: Haszpra Tímea , Tél Tamás 
Published: August 2013

Abstract
Topological entropy is shown to be a useful characteristic of the state of the free atmosphere. It can be determined as the stretching rate of a line segment of tracer particles in the atmosphere over a time span of about 10 days. Besides case studies, the seasonal distribution of the average topological entropy is determined in several geographical locations. The largest topological entropies appear in the mid- and high latitudes, especially in winter, owing to the greater temperature gradient between the pole and the equator and the more intense stirring and shearing effects of cyclones. The smallest values can be found in the trade wind belt. The local value of the topological entropy is a measure of the chaoticity of the state of the atmosphere and of how rapidly pollutants and contaminants spread from a given location.
Improving Antarctic Total Ozone Projections by a Process-Oriented Multiple Diagnostic Ensemble Regression
Authors: Karpechko Alexey Yu. , Maraun Douglas , Eyring Veronika 
Published: August 2013

AbstractAccurate projections of stratospheric ozone are required because ozone changes affect exposure to ultraviolet radiation and tropospheric climate. Unweighted multimodel ensemble-mean (uMMM) projections from chemistry–climate models (CCMs) are commonly used to project ozone in the twenty-first century, when ozone-depleting substances are expected to decline and greenhouse gases are expected to rise. Here, the authors address the question of whether Antarctic total column ozone projections in October given by the uMMM of CCM simulations can be improved by using a process-oriented multiple diagnostic ensemble regression (MDER) method. This method is based on the correlation between simulated future ozone and selected key processes relevant for stratospheric ozone under present-day conditions. The regression model is built using an algorithm that selects those process-oriented diagnostics that explain a significant fraction of the spread in the projected ozone among the CCMs. The regression model with observed diagnostics is then used to predict future ozone and associated uncertainty. The precision of the authors’ method is tested in a pseudoreality; that is, the prediction is validated against an independent CCM projection used to replace unavailable future observations. The tests show that MDER has higher precision than uMMM, suggesting an improvement in the estimate of future Antarctic ozone. The authors’ method projects that Antarctic total ozone will return to 1980 values at around 2055 with the 95% prediction interval ranging from 2035 to 2080. This reduces the range of return dates across the ensemble of CCMs by about a decade and suggests that the earliest simulated return dates are unlikely.
Improvement of High-Resolution Satellite Rainfall Product for Typhoon Morakot (2009) over Taiwan
Authors: Taniguchi Aina , Shige Shoichi , Yamamoto Munehisa K. , Mega Tomoaki , Kida Satoshi , Kubota Takuji , Kachi Misako , Ushio Tomoo , Aonashi Kazumasa 
Published: August 2013

AbstractThe authors improve the high-resolution Global Satellite Mapping of Precipitation (GSMaP) product for Typhoon Morakot (2009) over Taiwan by using an orographic/nonorographic rainfall classification scheme. For the estimation of the orographically forced upward motion used in the orographic/nonorographic rainfall classification scheme, the optimal horizontal length scale for averaging the elevation data is examined and found to be about 50 km. It is inferred that as the air ascends en masse on the horizontal scale, it becomes unstable and convection develops. The orographic/nonorographic rainfall classification scheme is extended to the GSMaP algorithm for all passive microwave radiometers in orbit, including not just microwave imagers but also microwave sounders. The retrieved rainfall rates, together with infrared images, are used for the high-resolution rainfall products, which leads to much better agreement with rain gauge observations.
Forecasting the New York City Urban Heat Island and Sea Breeze during Extreme Heat Events
Authors: Meir Talmor , Orton Philip M. , Pullen Julie , Holt Teddy , Thompson William T. , Arend Mark F. 
Published: August 2013

Abstract
Two extreme heat events impacting the New York City (NYC), New York, metropolitan region during 7–10 June and 21–24 July 2011 are examined in detail using a combination of models and observations. The U.S. Navy's Coupled Ocean–Atmosphere Mesoscale Prediction System (COAMPS) produces real-time forecasts across the region on a 1-km resolution grid and employs an urban canopy parameterization to account for the influence of the city on the atmosphere. Forecasts from the National Weather Service's 12-km resolution North American Mesoscale (NAM) implementation of the Weather Research and Forecasting (WRF) model are also examined. The accuracy of the forecasts is evaluated using a land- and coastline-based observation network. Observed temperatures reached 39°C or more at central urban sites over several days and remained high overnight due to urban heat island (UHI) effects, with a typical nighttime urban–rural temperature difference of 4°–5°C. Examining model performance broadly over both heat events and 27 sites, COAMPS has temperature RMS errors averaging 1.9°C, while NAM has RMSEs of 2.5°C. COAMPS high-resolution wind and temperature predictions captured key features of the observations. For example, during the early summer June heat event, the Long Island south shore coastline experienced a more pronounced sea breeze than was observed for the July heat wave.
Single bright light exposure decreases sweet taste threshold in healthy volunteers
Authors: Srivastava Shrikant , Donaldson Lucy F , Rai Dheeraj , Melichar Jan K , Potokar John 
Published: August 2013

Introduction: Bright light exposure can alter circulating serotonin levels, and alteration of available serotonin by acute selective serotonin reuptake inhibition significantly lowers sweet but not salt taste recognition thresholds. We tested the hypothesis that bright light exposure would increase sweet but not salt taste sensitivity in healthy adults. Methods: Fourteen healthy volunteers were exposed to bright (10,000 lux) and dim (<20 lux) light for 30 min each, in counterbalanced order. Measures of taste perception (salt and sweet) and mood were determined at baseline, and before and after each light exposure period. Results: Recognition thresholds for sucrose were significantly lower after bright but not dim light exposure. Thresholds for salt were unaffected by either condition. There were no significant changes in taste acuity, intensity or pleasantness for both the taste modalities and on visual analogue scales (VASs) for mood, anxiety, sleepiness and alertness, under either light condition. Conclusion: Brief bright light exposure reduces sweet but not salt taste recognition thresholds in healthy humans.
Ovarian volume and antral follicle count assessed by MRI and transvaginal ultrasonography: a methodological study
Authors: Leonhardt Henrik , Gull Berit , Stener-Victorin Elisabet , Hellström Mikael 
Published: August 2013

Background Ultrasonographic measurements of ovarian volume and antral follicle count are of clinical importance as diagnostic features of polycystic ovarian syndrome (PCOS), and as a parameter in estimation of ovarian follicular reserve in infertility care. Purpose To compare two-dimensional (2D)/three-dimensional (3D) transvaginal ultrasonography (TVUS) and magnetic resonance imaging (MRI) for estimation of ovarian volume and antral follicle count, and to assess reproducibility and inter-observer agreement of MRI measurements. Material and Methods Volumes of 172 ovaries in 99 women aged 21–37 years were calculated (length x width x height x 0.523) with conventional 2D TVUS and 2D MRI. Semi-automatic estimates of ovarian volumes were obtained by 3D MRI. Antral follicles were counted manually on 2D MRI and automatically by 3D TVUS (SonoAVC), and stratified according to follicle size. Results Mean ovarian volume assessed by 2D TVUS (13.1 ± 6.4 mL) was larger than assessed by 2D MRI (9.6 ± 4.1) and 3D MRI (11.4 ± 4.5) ( P < 0.001). Total follicle count was higher by 2D MRI than by 3D TVUS, mean difference 14.3 ± 16.2 follicles ( P < 0.001). In the smallest size interval of 1–3 mm the mean difference was 22.2 ± 17.6 ( P < 0.001). Intra- and inter-observer absolute agreement assessment for MRI measurements of ovarian volume and total follicle count showed ICC coefficients >0.77. Conclusion 2D MRI reveals more antral follicles, especially of small size, than 3D TVUS. Ovarian volume estimation by MRI provides smaller volumes than by the reference standard 2D TVUS. Ovarian volume estimation by 3D MRI, allowing independence of non-ellipsoid ovarian shape measurement errors, provides volumes closer to 2D TVUS values than does 2D MRI. Reproducibility and inter-observer agreement of 2D MRI measurements of ovarian volume and total follicle count are good.
Three-phase, contrast-enhanced, multidetector CT in the evaluation of complicated renal cysts: comparison of the postcontrast phase combination
Authors: Kim Mi-hyun , Yi Rang , Cho Kyoung-Sik , Choi Hyuck Jae 
Published: August 2013

Background Multiphasic multidetector computed tomography (MDCT) is widely used for the assessment and diagnosis of complicated renal cysts. Purpose To determine the optimal combination of postcontrast phases of MDCT for the evaluation of complicated renal cysts. Material and Methods In 164 renal cysts with pathology confirmation or follow-up >2 years, the Bosniak category was recorded by two radiologists in consensus. They reviewed the MDCT images during three interpretation sessions. In the first session, the radiologists evaluated two phases of images (unenhanced and corticomedullary phases), while during the second session, they evaluated two phases of images (unenhanced and parenchymal phases), and in the third session, they evaluated all three phases of images (unenhanced, corticomedullary, and parenchymal phases). The diagnostic accuracy for evaluating renal cysts was compared in each session using receiver-operating characteristics (ROC) analysis. Results There were 106 benign renal cysts and 58 malignant renal cysts. The areas under the ROC curves (AUCs) of the second and third sessions were greater than that of the first session ( P < 0.05). The sensitivity, specificity, positive predictive value, and negative predictive value of the first session were 74%, 88%, 77%, and 86%, respectively, and those of the second session were 90%, 85%, 77%, and 94%, respectively. The values of the third session were identical to those of the second session. Conclusion Unenhanced and parenchymal phase CT scans are sufficient for differentiating malignant from benign renal cysts and there was no additional value by adding the corticomedullary phase to the combination of unenhanced and parenchymal phase CT.