bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of two hyaluronic acid formulations for safety and efficacy (CHASE) study in knee osteoarthritis: a multicenter, randomized, double-blind, 26-week non-inferiority trial comparing Durolane to Artz
Authors: Zhang Heng , Zhang Ke , Zhang Xianlong , Zhu Zhenan , Yan Shigui , Sun Tiansheng , Guo Ai , Jones John , Steen R Grant , Shan Bin , Zhang Jenny , Lin Jianhao 
Published: March 2015

Abstract
Introduction
Intra-articular injection of hyaluronic acid (HA) is often used as therapy for knee osteoarthritis because it is less expensive and less aggressive than total knee replacement. Therefore, it is important to document whether HA is safe and efficacious. We tested whether single and multiple injection viscosupplementation with HA is associated with clinically meaningful pain relief in a new randomized clinical trial (RCT). Our objective was to compare safety and efficacy of intra-articular HA in two formulations: one 3.0 ml injection of Durolane versus five 2.5 ml injections of Artz for the treatment of knee osteoarthritis pain.

Methods
Patients (N = 349) from the People’s Republic of China were randomized to treatment (Durolane = 175, Artz = 174). The Durolane group received a 3.0 ml injection at week 0 (baseline), with sham skin punctures at weeks 1, 2, 3, and 4. The Artz group received one 2.5 ml injection at each of the same time points. The primary assessment tool was the Likert-type Western Ontario and McMaster University (WOMAC) pain scale at weeks 0, 6, 10, 14, 18, and 26. Secondary assessments were WOMAC physical function, knee stiffness, and global self-assessment, at identical time points. Statistically-controlled analyses were non-inferiority of Durolane over 18, then over 26 weeks, with a priori non-inferiority defined as 8% of the relevant scale. Acetaminophen was permitted as rescue analgesia and all adverse events (AEs) were recorded.

Results
Overall study retention was excellent; 332 patients (95.1%) completed 18 weeks and 319 (91.4%) completed 26 weeks, with no significant retention difference between treatment arms. All variables met non-inferiority criteria over 18 and 26 weeks. Efficacy response in both arms was >90%. Treatment-related AEs were 9.8% (17/174) for Artz and 13.1% (23/175) for Durolane.

Conclusions
A single injection of Durolane is non-inferior to 5 injections of Artz over 18 and 26 weeks for pain, physical function, global self-assessment, and knee stiffness. Both treatments were efficacious, safe, and well tolerated.

Trial registration
ClinicalTrials.gov NCT01295580. Registered 11 February 2011.
Characterising deviation from treat-to-target strategies for early rheumatoid arthritis: the first three years
Authors: Wabe Nasir , Sorich Michael J , Wechalekar Mihir D , Cleland Leslie G , McWilliams Leah , Lee Anita , Spargo Llewellyn , Metcalf Robert G , Hall Cindy , Proudman Susanna M , Wiese Michael D 
Published: March 2015

Abstract
Introduction
Treat-to-target (T2T) strategies using a protocol of pre-defined adjustments of disease-modifying anti-rheumatic drugs (DMARDs) according to disease activity improve outcomes for patients with rheumatoid arthritis (RA). However, successful implementation may be limited by deviations from the protocol. The aim of this study was to determine the prevalence of protocol deviation, explore the reasons and identify subsets of patients in whom treatment protocols are more difficult to follow.

Methods
In this retrospective cohort study, treatment-naïve patients with RA of less than one year’s duration, attending a dedicated early arthritis clinic between 2001 and 2013, were followed for three years from initiation of combination therapy with conventional DMARDs which was subsequently modified according to a T2T protocol. At each clinic visit, whether deviation from the protocol occurred, the type of deviation and the reasons for deviation were assessed. The relationship between protocol deviations and baseline variables was determined using linear regression analysis.

Results
In total, 198 patients contributed 3,654 clinic visits. The prevalence of protocol deviations was 24.5% and deviation in at least at one clinic visit was experienced by 90.4% of patients. The median time to first deviation was 30 weeks. Continuing existing treatment rather than intensifying therapy was the most common type of deviation (59.9%). Patient and physician related factors were the most common reasons for deviation, each accounting for 24.7% of deviations, followed by toxicities (23.3%) and comorbidities (20.0%). The prevalence of protocol deviations was lower among patients who achieved remission after three years (13.1%; 162 deviations out of 1,228 visits) compared with those who were not in remission (30.9%; 523/1692) (P <0.0001). On multivariate analysis, only body mass index (P = 0.003) and helplessness score (P = 0.04) were independent predictors of protocol deviations although the predictive power of the model was not strong (R
2
= 0.17).

Conclusions
Deviation from a T2T protocol occurred in one quarter of visits, indicating that applying the T2T approach is feasible in clinical practice. Failure to escalate dose when indicated was commonly encountered, and just under half of the observed deviations were related to either toxicities or comorbidities and were therefore justifiable on clinical grounds.
Non-invasive in vivo imaging of arthritis in a collagen-induced murine model with phosphatidylserine-binding near-infrared (NIR) dye
Authors: Chan Marion M , Gray Brian D , Pak Koon Y , Fong Dunne 
Published: March 2015

Abstract
Introduction
Development of non-invasive molecular imaging techniques that are based on cellular changes in inflammation has been of active interest for arthritis diagnosis. This technology will allow real-time detection of tissue damage and facilitate earlier treatment of the disease, thus representing an improvement over X-rays, which detect bone damage at the advanced stage. Tracing apoptosis, an event occurring in inflammation, has been a strategy used. PSVue 794 is a low-molecular-weight, near-infrared (NIR)-emitting complex of bis(zinc2+-dipicolylamine) (Zn-DPA) that binds to phosphatidylserine (PS), a plasma membrane anionic phospholipid that becomes flipped externally upon cell death by apoptosis. In this study, we evaluated the capacity of PSVue 794 to act as an in vivo probe for non-invasive molecular imaging assessment of rheumatoid arthritis (RA) via metabolic function in murine collagen-induced arthritis, a widely adopted animal model for RA.

Methods
Male DBA/1 strain mice were treated twice with chicken collagen type II in Freund’s adjuvant. Their arthritis development was determined by measuring footpad thickness and confirmed with X-ray analysis and histology. In vivo imaging was performed with the NIR dye and the LI-COR Odyssey Image System. The level of emission was compared among mice with different disease severity, non-arthritic mice and arthritic mice injected with a control dye without the Zn-DPA targeting moiety.

Results
Fluorescent emission correlated reliably with the degree of footpad swelling and the manifestation of arthritis. Ex vivo examination showed emission was from the joint. Specificity of binding was confirmed by the lack of emission when arthritic mice were given the control dye. Furthermore, the PS-binding protein annexin V displaced the NIR dye from binding, and the difference in emission was numerically measurable on a scale.

Conclusions
This report introduces an economical alternative method for assessing arthritis non-invasively in murine models. Inflammation in feet and ankles can be measured longitudinally using the PSVue 794 probe for cell death and with a commonly available multipurpose imager. This technique provides metabolic and functional information that anatomical measurement of footpad swelling or visual determination of arthritic index cannot. It also may decrease the number of animals required per experiment because tissue damage will not necessarily require evaluation by harvesting joints for histology.
A practical approach to vitamin and mineral supplementation in food allergic children
Authors: Meyer Rosan , De Koker Claire , Dziubak Robert , Skrapac Ana‐Kristina , Godwin Heather , Reeve Kate , Chebar‐Lozinsky Adriana , Shah Neil 
Published: March 2015

AbstractBackgroundThe management of food allergy in children requires elimination of the offending allergens, which significantly contribute to micronutrient intake. Vitamin and mineral supplementation are commonly suggested as part of dietary management. However a targeted supplementation regime requires a complete nutritional assessment, which includes food diaries. Ideally these should be analysed using a computerised program, but are very time consuming. We therefore set out to evaluate current practice of vitamin and mineral supplementation in a cohort of children with non‐Immunoglobulin E (IgE) mediated food allergies.MethodsThis prospective, observational study recruited children aged 4 weeks – 16 years, who required to follow an elimination diet for non‐IgE mediated allergies. Only children that improved according to a symptom score and were on a vitamin and/or mineral supplement were included. A 3‐day food diary including vitamin and mineral supplementation was recorded and analysed using Dietplan computer program. We assessed dietary adequacy with/without the supplement using the Dietary Reference Values.ResultsOne hundred‐and‐ten children had completed food diaries and of these 29% (32/110) were taking vitamin and/or mineral supplements. Children on hypoallergenic formulas were significantly (p = 0.007) less likely to be on supplements than those on alternative over‐the‐counter milks. Seventy‐one percent had prescribable supplements, suggested by a dietitian/physician. Sixty percent of those without a vitamin supplement had a low vitamin D intake, but low zinc, calcium and selenium was also common. Of the supplemented cohort many continued to be either under or over‐supplemented.ConclusionThis study has raised the question for the first time, whether clinicians dealing with paediatric food allergies should consider routine vitamin and/or mineral supplements in the light of deficient intake being so common in addition to being so difficult to predict.
Fairness scheme for energy efficient H.264/AVC-based video sensor network
Authors: Sarif Bambang AB , Pourazad Mahsa T , Nasiopoulos Panos , Leung Victor CM , Mohamed Amr 
Published: March 2015

AbstractThe availability of advanced wireless sensor nodes enable us to use video processing techniques in a wireless sensor network (WSN) platform. Such paradigm can be used to implement video sensor networks (VSNs) that can serve as an alternative to existing video surveillance applications. However, video processing requires tremendous resources in terms of computation and transmission of the encoded video. As the most widely used video codec, H.264/AVC comes with a number of advanced encoding tools that can be tailored to suit a wide range of applications. Therefore, in order to get an optimal encoding performance for the VSN, it is essential to find the right encoding configuration and setting parameters for each VSN node based on the content being captured. In fact, the environment at which the VSN is deployed affects not only the content captured by the VSN node but also the node’s performance in terms of power consumption and its life-time. The objective of this study is to maximize the lifetime of the VSN by exploiting the trade-off between encoding and communication on sensor nodes. In order to reduce VSNs’ power consumption and obtain a more balanced energy consumption among VSN nodes, we use a branch and bound optimization techniques on a finite set of encoder configuration settings called configuration IDs (CIDs) and a fairness-based scheme. In our approach, the bitrate allocation in terms of fairness ratio per each node is obtained from the training sequences and is used to select appropriate encoder configuration settings for the test sequences. We use real life content of three different possible scenes of VSNs’ implementation with different levels of complexity in our study. Performance evaluations show that the proposed optimization technique manages to balance VSN’s power consumption per each node while the nodes’ maximum power consumption is minimized. We show that by using that approach, the VSN’s power consumption is reduced by around 7.58% in average.
MELK—a conserved kinase: functions, signaling, cancer, and controversy
Authors: Ganguly Ranjit , Mohyeldin Ahmed , Thiel Jordyn , Kornblum Harley I , Beullens Monique , Nakano Ichiro 
Published: March 2015

AbstractMaternal embryonic leucine zipper kinase (MELK) is a highly conserved serine/threonine kinase initially found to be expressed in a wide range of early embryonic cellular stages, and as a result has been implicated in embryogenesis and cell cycle control. Recent evidence has identified a broader spectrum of tissue expression pattern for this kinase than previously appreciated. MELK is expressed in several human cancers and stem cell populations. Unique spatial and temporal patterns of expression within these tissues suggest that MELK plays a prominent role in cell cycle control, cell proliferation, apoptosis, cell migration, cell renewal, embryogenesis, oncogenesis, and cancer treatment resistance and recurrence. These findings have important implications for our understanding of development, disease, and cancer therapeutics. Furthermore understanding MELK signaling may elucidate an added dimension of stem cell control.
Nanomeniscus-induced delivery of liquid solutions for diverse nanofiber fabrication
Authors: An Sangmin , Kim Bongsu , Kwon Soyoung , Lee Kunyoung , Kim Jongwoo , Ahn Heejoon , Jhe Wonho 
Published: March 2015

Abstract
Nanomaterial-delivery fabrication expects high-potential impacts on nanoscience, technology and industry, but still faces limited applicability mainly due to high-field requirement for liquid delivery, complicated intermediate processes, and narrow ink selectivity. Here, we demonstrates a simple, non-template, non-contact and electric field-free fabrication of diverse nanofibers. The process consists of continuous, meniscus-assisted delivery of liquid solutions through a nanoapertured nozzle in ambient conditions, followed by subsequent evaporation of liquid and aggregation of nanoparticle residues. For example, the carbon-nanotube nanofibers of 500 nm diameter exhibit a high shear modulus of ~1.5 GPa and current density up to 104 A/cm2. The results provide a unique, universal and versatile tool with wide selectivity in both ink and substrate.
Classification of eating disorders: comparison of relative prevalence rates using DSM-IV and DSM-5 criteria
Authors: Mancuso Serafino G. , Newton J. Richard , Bosanac Peter , Rossell Susan L. , Nesci Julian B. , Castle David J. 
Published: March 2015

SummaryDSM-5 contains substantial changes to eating disorder diagnoses. We examined relative prevalence rates of DSM-IV and DSM-5 eating disorder diagnoses using Eating Disorder Examination–Questionnaire diagnostic algorithms in 117 community out-patients. DSM-5 criteria produced a reduction in combined ‘other specified feeding or eating disorder’ and ‘unspecified feeding or eating disorder’ diagnoses from 46% to 29%, an increase in anorexia nervosa diagnoses from 35% to 47%, the same number of bulimia nervosa diagnoses and a 5% rate of binge eating disorder diagnoses.
Modulatory effects of brain-derived neurotrophic factor Val66Met polymorphism on prefrontal regions in major depressive disorder
Authors: Legge Rebecca MacGregor , Sendi Shahbaz , Cole James H. , Cohen-Woods Sarah , Costafreda Sergi G. , Simmons Andrew , Farmer Anne E. , Aitchison Katherine J. , McGuffin Peter , Fu Cynthia H. Y. 
Published: March 2015

BackgroundBrain-derived neurotrophic factor (BDNF) Val66Met polymorphism contributes to the development of depression (major depressive disorder, MDD), but it is unclear whether neural effects observed in healthy individuals are sustained in MDD.AimsTo investigate BDNF Val66Met effects on key regions in MDD neurocircuitry: amygdala, anterior cingulate, middle frontal and orbitofrontal regions.MethodMagnetic resonance imaging scans were acquired in 79 persons with MDD (mean age 49 years) and 74 healthy volunteers (mean age 50 years). Effects on surface area and cortical thickness were examined with multiple comparison correction.ResultsPeople who were Met allele carriers showed reduced caudal middle frontal thickness in both study groups. Significant interaction effects were found in the anterior cingulate and rostral middle frontal regions, in which participants in the MDD group who were Met carriers showed the greatest reduction in surface area.ConclusionsModulatory effects of the BDNF Val66Met polymorphism on distinct subregions in the prefrontal cortex in MDD support the neurotrophin model of depression.
Multistimuli-responsive Hydrogel Particles Prepared via the Self-assembly of PEG-based Hyperbranched Polymers
Authors: Chen Qian-Bao , You Ye-Zi 
Published: March 2015

Abstract
Generally, it is very difficult to obtain multistimuli-responsive hydrogel particles. Here, we introduce a novel method for the preparation of multistimuli-responsive hydrogel particles by adding water into the poly(ethylene glycol) (PEG)-based hyperbranched polymers. The produced PEG-base polymers via reversible addition–fragmentation chain transfer (RAFT) polymerization become temperature-sensitive and less soluble when heated above the lower critical solution temperature (LCST) after directly adding water. Subsequently, the hydrogel particles can be formed via hyperbranch–hyperbranch coupling through disulfide exchange. The resulting hydrogel particles are temperature-, photo-, and redox-responsive.
Service activities of peasants in Moscow in the middle of XVIII century
Authors: Прохоров Михаил , Prokhorov Mikhail 
Published: March 2015

The author examines the role of the serfs in the provision of services to Muscovites in the middle of the eighteenth century. This topic is insufficiently developed in the national historiography, although some issues have been raised in the literature. Source base of the study is represented by assembly records, contractor papers, residential papers, loans, petitions, letters, properly inventories of the time. Sources allow to analyze the leading forms of services for citizens in manufacturing, construction, small commodity production, monetary operations, catering, trade and everyday life. The paper clarified the basic features and characteristics of the service activities of peasants, the extent of supply of consumer services, profitability. The facts indicate the focus of the individual counties and villages on specialization in services and delivery to Moscow sutlers, gardeners, textile workers, bricklayers.
Particular attention is paid to the formation of large, medium and small businesses among peasants, active use of family and hired labor. Subjected to analysis are activities in the field of service and wholesale trade of rich peasants as Sezemov and Belousov.
Particular emphasis is placed on clarification of Moscow life and everyday way of life of peasant entrepreneurs, how they developed their ethical conduct and public demands for power, how they adapted to city life.
The study shows that participation of peasants in services for Muscovites had both consumer and entrepreneurial nature. In its activities, peasants used various forms of service: custom work and to the market, provision of individual and collective services, participation in a stationary, wholesale trade and retail, etc. Evidences suggest that business cooperation gradually blured the line between castes of merchants, burghers and peasants, who were united by a partnership, success and profit.
The results may be useful for the formation of an information base of research on the history of service and business in Russia.
Wireless Visual Sensor Network Robots Based for the Emulation of Collective Behavior
Authors: Martínez Sarmiento Fredy Hernán , Delgado Jesús Alberto 
Published: March 2015

We consider the problem of bacterial quorum Sensing emulate on small mobile robots. Robots that reflect the behavior of bacteria are designed as mobile wireless camera nodes. They are able to structure a dynamic wireless sensor network. Emulated behavior corresponds to a simplification of bacterial quórum sensing, where the action of a network node is conditioned by the population density of robots (nodes) in a given area. The population density Reading is done visually using a camera. The robot makes an estímate of the population density of the images, and acts according to this information. The operation of the camera is done whit a custom firmware, reducing the complexity of the node without the use of any other external or local commuication. Neither was it necessary to develop a model system, precise state estimation or state feedback.
Software basado en agentes inteligentes y servicios web para búsqueda de productos en la web
Authors: Espejo Bohórquez Yeismer , Téllez Magaly , Rodríguez Rodríguez Jorge Enrique 
Published: March 2015

La localización y recuperación de la información en la Web es uno de los principales retos en la actualidad. Existen diferentes herramientas que permiten la búsqueda de información en la Web: los motores de búsqueda, los índices temáticos o directorios y los metabuscadores. Estas aplicaciones pese a los problemas de poca exhaustividad, baja precisión y el gran porcentaje de recursos repetidos e inactivos que arrojan son las más utilizadas a la hora de comparar productos y precios en la red. Existe otra aproximación que pretende obtener resultados mucho más precisos, basándose en el uso de agentes inteligentes que rastrean la red según las necesidades informativas del usuario.
Comparación del modelo FARIMA y SFARIMA para obtener la mejor estimación del tráfico en una red Wi-Fi
Authors: Carroll Vargas Joel , Hernández Cesar A. , Puerta Aponte Gabriel Alberto 
Published: March 2015

El presente artículo se enfoca en el análisis del tráfico de la red WI-FI pública de Chía, Cundinamarca, determinando la presencia de tráfico auto similar y aplicando posteriormente los algoritmos FARIMA y SFARIMA. Los resultados determinan cuál es el mejor predictor del tráfico de la red.
Uso de residuos agrícolas para la producción de biocombustibles en el departamento del Meta
Authors: Núñez Camargo Danny Williams 
Published: March 2015

El departamento del Meta tiene una tradición agrícola sobresaliente en diferentes productos como: la palma africana, arroz, frutales, plátano, y otros; los cuales, dentro de los diferentes procesos agrícolas o de transformación, producen residuos heterogéneos, especialmente biomasa, que representa un problema desde el punto de vista ambiental debido a la falta de técnicas para su aprovechamiento y re-uso. Estos subproductos de la producción agrícola y agro industrial pueden generar beneficios para los productores; logrando el uso en la obtención de compostaje y devueltos al cultivo; o con una gran posibilidad de re-usarse en la producción de energía para diferentes procesos, dentro de una producción agrícola o para generar energía para la agroindustria, supliendo el uso de energía proveniente del carbón, diesel y gasolina, entre otros. El objetivo de este artículo es describir, analizar y generar posibilidades de convertir estos residuos o subproductos en fuente de energía para la región, para municipios alejados del sistema interconectado nacional, además de la posibilidad de obtener biocombustibles como: etanol, biogás y biodiesel para suplir las demandas energéticas. Promocionando la seguridad energética, uso racional y eficiente de los recursos y la integración regional. Siempre relacionado con la reducción de emisiones de gases, efecto invernadero, minimización de la disposición de los contaminantes en el suelo, agua y aire; para lograr, en un mundo globalizado, la mayor competitividad usando adecuadamente la biomasa producida en diferentes procesos.