bluuebunny/crossref_metadata_2025_split huggingface dataset:
CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation
Authors: Zeng Xixi , Tang Jielin , Zhang Qian , Wang Chenxing , Qi Ji , Wei Yusi , Xu Jiali , Yang Kaiyuan , Zhou Zuolin , Wu Hao , Luo Jiarong , Jiang Yi , Song Zengqiang , Wu Jinyu , Wu Jianmin 
Published: July 2024

AbstractColorectal cancer (CRC) and inflammatory bowel disease (IBD) are escalating global health concerns. Despite their distinct clinical presentations, both disorders share intricate genetic and molecular interactions. The Hippo signaling pathway plays a crucial role in regulating cell processes and is implicated in the pathogenesis of IBD and CRC. Circular RNAs (circRNAs) have gained attention for their roles in various diseases, including IBD and CRC. However, a comprehensive understanding of specific circRNAs involved in both IBD and CRC, and their functional roles is lacking. Here, it is found that circHIPK2 (hsa_circRNA_104507) is a bona fide circRNA consistently upregulated in both IBD and CRC suggesting its potential as a biomarker. Furthermore, silencing of circHIPK2 suppressed the growth of CRC cells in vitro and in vivo. Interestingly, decreased circHipk2 potentiated dextran sulfate sodium (DSS)‐induced colitis but alleviated colitis‐associated tumorigenesis. Most significantly, mechanistic investigations further unveil that circHIPK2, mediated by FUS, interacting with EIF4A3 to promote the translation of TAZ, ultimately increasing the transcription of downstream target genes CCN1 and CCN2. Taken together, circHIPK2 emerges as a key player in the shared mechanisms of IBD and CRC, modulating the Hippo signaling pathway. CircHIPK2‐EIF4A3 axis contributes to cell growth in intestinal epithelial of colitis and CRC by enhancing TAZ translation.
Oriented Structures for High Safety, Rate Capability, and Energy Density Lithium Metal Batteries
Authors: Wang Kaiming , Tieu Aaron Jue Kang , Wu Haowen , Shen Fei , Han Xiaogang , Adams Stefan 
Published: July 2024

AbstractLithium metal batteries (LMBs) have emerged in recent years as highly promising candidates for high‐density energy storage systems. Despite their immense potential, mutual constraints arise when optimizing energy density, rate capability, and operational safety, which greatly hinder the commercialization of LMBs. The utilization of oriented structures in LMBs appears as a promising strategy to address three key performance barriers: 1) low efficiency of active material utilization at high surface loading, 2) easy formation of Li dendrites and damage to interfaces under high‐rate cycling, and 3) low ionic conductivity of solid‐state electrolytes in high safety LMBs. This review aims to holistically introduce the concept of oriented structures, provide criteria for quantifying the degree of orientation, and elucidate their systematic effects on the properties of materials and devices. Furthermore, a detailed categorization of oriented structures is proposed to offer more precise guidance for the design of LMBs. This review also provides a comprehensive summary of preparation techniques for oriented structures and delves into the mechanisms by which these can enhance the energy density, rate capability, and safety of LMBs. Finally, potential applications of oriented structures in LMBs and the crucial challenges that need to be addressed in this field are explored.
Ni–Ca metastable–nonmetastable bimetallic sites induced ·OH directed generation and efficient water purification
Authors: Qin Jiahua , Liu Feng , Zhou Zhiyong , Du Chencan , Tu Yuming , Ren Zhongqi 
Published: July 2024

AbstractStrongly oxidizing ·OH can non‐selectively degrade various organic pollutants, but how to selectively generate ·OH is a great challenge. In this study, the directed generation of ·OH was achieved based on Ni–Ca metastable–nonmetastable bimetallic sites, Ni2+/Ni3+ valence cycling provided electrons for ·OH generation induced by the non‐variable Ca‐based sites, which constructed a nearly 100% selective generation pathway of ·OH (O3 → HO3/HO2 → OH). The antibiotic pefloxacin could be completely removed in 15 min, and the COD removal efficiency for other hard‐to‐degrade pollutants such as oxalic acid and chlorobenzoic acid could reach more than 90%. Ni doping significantly increased the oxygen vacancy and Lewis acid content, and DFT calculations showed that Ni–Ca dual‐site had a lower reaction energy barrier and the complexed hydroxyl radical intermediate *OO had a higher spin density (−0.6), which was more favorable for the generation of ·OH. Therefore, this study provides new ideas for efficient treatment of actual wastewater.
Eine Strep‐Tag‐geprägte Polymer‐Plattform für die heterogene Bio(elektro)katalyse
Authors: Yarman Aysu , Waffo Armel F. T. , Katz Sagie , Bernitzky Cornelius , Kovács Norbert , Borrero Paloma , Frielingsdorf Stefan , Supala Eszter , Dragelj Jovan , Kurbanoglu Sevinc , Neumann Bettina , Lenz Oliver , Mroginski Maria Andrea , Gyurcsányi Róbert E. , Wollenberger Ulla , Scheller Frieder W. , Caserta Giorgio , Zebger Ingo 
Published: July 2024

AbstractMolekular geprägte Polymere (MIPs) sind künstliche Rezeptoren mit selektiven Erkennungsstellen für Zielmoleküle. Eine der vielversprechendsten Strategien für Protein‐MIPs beruht auf der Nutzung kurzer, oberflächenexponierter Proteinfragmente, sogenannter Epitope, als Schablonen für die Prägung von Bindungsstellen in einem Polymergerüst für ein spezifisches (Ziel‐)Protein. Der Mangel an hochauflösenden Strukturdaten von flexiblen oberflächenexponierten Regionen erschwert jedoch die Auswahl geeigneter Epitope. Hier haben wir diesen Nachteil durch die Entwicklung eines MIPs auf Polyscopoletin‐Basis behoben, das rekombinante Proteine über das weit verbreitete Affinitätspeptid Strep‐tag II erkennt. Elektrochemie, oberflächensensitive IR‐Spektroskopie und Molekulardynamiksimulationen wurden eingesetzt, um eine größtmögliche Kontrolle der Strep‐MIP‐Elektrosynthese zu gewährleisten. Die Funktionalität dieser neuartigen Plattform wurde mit zwei Strep‐Tag‐markierten Enzymen überprüft: einer O2‐toleranten [NiFe]‐Hydrogenase und einer alkalischen Phosphatase. Beide Enzyme behielten ihre biokatalytischen Aktivitäten nach mehrfacher Verwendung und bestätigten damit die Effizienz von dem Strep‐MIP als generell biokompatible Plattform zur Bindung rekombinanter Proteine für die Nutzung in der Biotechnologie.
Plasma soluble fms‐like tyrosine kinase‐1, placental growth factor, and vascular endothelial growth factor system gene variants as predictors of survival in heart failure
Authors: Paterson Melinda A. , Pilbrow Anna P. , Frampton Chris M. , Cameron Vicky A. , Troughton Richard W. , Pemberton Chris J. , Lund Mayanna , Devlin Gerard P. , Richards A. Mark , Doughty Robert N. , Palmer Barry R. 
Published: July 2024

AbstractAimsSoluble fms‐like tyrosine kinase‐1 (sFlt‐1) and placental growth factor (PlGF), components of the vascular endothelial growth factor (VEGF) system, play key roles in angiogenesis. Reports of elevated plasma levels of sFlt‐1 and PlGF in coronary heart disease and heart failure (HF) led us to investigate their utility, and VEGF system gene single nucleotide polymorphisms (SNPs), as prognostic biomarkers in HF.Methods and resultsELISA assays for sFlt‐1, PlGF and N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP) were performed on baseline plasma samples from the PEOPLE cohort (n = 890), a study of outcomes among patients after an episode of acute decompensated HF. Eight SNPs potentially associated with sFlt‐1 or PlGF levels were genotyped. sFlt‐1 and PlGF were assayed in 201 subjects from the Canterbury Healthy Volunteers Study (CHVS) matched to PEOPLE participants. All‐cause death was the major endpoint for clinical outcome considered. In PEOPLE participants, mean plasma levels for both sFlt‐1 (125 ± 2.01 pg/ml) and PlGF (17.5 ± 0.21 pg/ml) were higher (both p < 0.044) than in the CHVS cohort (81.2 ± 1.31 pg/ml and 15.5 ± 0.32 pg/ml, respectively). sFlt‐1 was higher in HF with reduced ejection fraction compared to HF with preserved ejection fraction (p = 0.005). The PGF gene SNP rs2268616 was univariately associated with death (p = 0.016), and was also associated with PlGF levels, as was rs2268614 genotype. Cox proportional hazards modelling (n = 695, 246 deaths) showed plasma sFlt‐1, but not PlGF, predicted survival (hazard ratio 6.44, 95% confidence interval 2.57–16.1; p < 0.001) in PEOPLE, independent of age, NT‐proBNP, ischaemic aetiology, diabetic status and beta‐blocker therapy.ConclusionsPlasma sFlt‐1 concentrations have potential as an independent predictor of survival and may be complementary to established prognostic biomarkers in HF.
Behaviourally assessed negative urgency is uniquely associated with binge‐eating frequency
Authors: Forester Glen , Wonderlich Joseph A. , Bottera Angeline R. , Dougherty Elizabeth N. , Day Maya , Pearson Carolyn M. , Peterson Carol B. , Anderson Lisa M. 
Published: July 2024

AbstractObjectiveBinge eating appears to be associated with impulsivity, especially in response to negative affect (i.e., negative urgency). However, negative urgency is typically assessed via self‐report, which captures only some aspects of urgency and may be subject to bias. Few studies have examined impulsivity following experimental manipulations of affect in binge‐eating samples.MethodIn the present study, individuals who engage in regular binge eating completed a behavioural impulsivity (go/no‐go) task with high‐ and low‐calorie food stimuli, once following negative affect induction and once following neutral affect induction.ResultsGreater behavioural impulsivity to high‐calorie food cues while in a negative (and not a neutral) affective state was associated with more frequent binge‐eating behaviour. Further, this behavioural measure of negative urgency uniquely accounted for variance in binge‐eating frequency when controlling for self‐reported negative urgency, suggesting that behavioural measures may be a useful complement to self‐report measures.DiscussionThese findings provide novel and compelling evidence for the relationship between negative urgency and binge eating, highlighting negative urgency as a potentially important target for intervention.
Lanthanum‐Nickel‐Based Mixed‐Oxide‐Coated Nickel Electrodes for the OER Electrocatalysis
Authors: Kubo Nikolas Mao , Mhamdi Rim , Palkovits Regina 
Published: July 2024

ABSTRACTThe anodic oxygen evolution reaction (OER) remains a bottleneck for electrocatalytic water splitting due to its sluggish kinetics and, thus, high overpotentials. This limits water electrolysis as a key technology for the generation of hydrogen as a sustainable alternative to fossil fuels. For alkaline water splitting, perovskite phases (ABO3) with earth‐abundant first‐row transition‐metals have emerged as a promising material class for OER electrocatalysts. Among these, LaNiO3 has been found to exhibit high intrinsic OER activity. To increase catalyst utilization, a high surface area of the catalyst is desirable and can be achieved by impregnation of porous templates. In this work, La–Ni‐based oxides were prepared via impregnation of activated carbon and subsequent heating, combining precursor calcination and template removal into one step. The phase structure of the samples is analyzed via powder X‐ray diffractometry, and the morphology is determined by scanning electron microscopy. The synergistic effect of B‐site mixing iron as well as A‐site mixing strontium into LaNiO3 is studied and found to increase its OER activity, confirming the activity‐enhancing effect of Fe in Ni‐based OER electrocatalysts. To allow for facile technical application of the catalysts, the electrodes are prepared by coating a perovskite ink onto Ni‐metal as industrially relevant substrates, followed by calcination.
An Ediacaran glacial deposit in southern margin of the North China Craton: The Luoquan Formation—sedimentology, geochronology and provenance
Authors: Wu Chunyan , Hua Hong , Zeng Zhongcheng , Zheng Yuanfang , Yang Dandan , Jiao Rui 
Published: July 2024

The end of the Neoproterozoic global ice age has promoted the evolution of the Earth's surface system and initiated the ‘Great Explosion of Life’. Glaciation deposits provide valuable insights into the extreme climate conditions. In the southern margin of the North China Craton (NCC), an Ediacaran glacial deposit named ‘Luoquan Formation’ has been recently described in Luonan County, Shaanxi Province. It has significant characteristics of dark grey and black glacial deposits. Through extensive research in sedimentology, geochemistry and geochronology, the glacial sedimentary evolution sequence of the Luoquan Formation has been established. This research also help to define the age of the formation and reveal its provenance and sedimentary environment. The study reveals that four lithofacies associations were identified in the Luoquan Formation: diamictites, carbonates, dropstone‐bearing rock and black shale. The Luoquan Formation has experienced three cycles of glacial advance–retreat. Sedimentological evidence suggests that the sedimentary environments of the Luoquan Formation evolved from subglacial (diamictite) to intertidal, then to intertidal lagoon, or from subglacial deposits to shoreface (inner shelf, subtidal), then to deep water basin and fine‐grained turbidite and ice‐rafting. The age of the Luoquan Formation is estimated to be 562–550 Ma constrained by indirect chronological and paleontological data, maybe representing an Upper Ediacaran glaciation that occurred later than the Gaskiers glaciation. The overall age profile of detrital zircons from the Luoquan Formation can be divided into six groups, ranging from 1.1 to 1.6, 1.85 to 1.95, ~2.1, ~2.3, ~2.5 and 2.65 to 2.9 Ga. These age groups are consistent with the Archean to Meso‐Neoproterozoic magmatic–tectonic events in the southern margin of NCC, indicating they are ascribed to an origination directly from the southern margin of NCC. The Luoquan Formation exhibits the characteristics of isochronous and different sedimentary facies, with the glacial front moving from north to south. The discovery of Luoquan Formation in Lianshuigou section not only reflects the important significance of the restoration and reconstruction of the Ediacaran ice age, paleoenvironment and palaeogeography of the NCC but also provides significant evidence to support the further subdivision and correlation within the Ediacaran glacial deposits globally.
TET2 regulates extranodal NK/T cell lymphoma progression through regulation of DNA methylation
Authors: Xiang Chunxiang , Gao Limin , Tao Qing , Chen Zihang , Zhao Sha , Liu Weiping 
Published: July 2024

AbstractThe biological role of Ten‐11 translocation 2 (TET2) and the conversion of 5‐methylcytosine (5mC) to 5‐hydroxymethylcytosine (5hmC) in the development of extra‐nodal natural killer/T‐cell lymphoma (ENKTL) remains unclear. The level of 5mC and 5hmC was detected in 112 cases of ENKTL tissue specimens by immunohistochemical (IHC) staining. Subsequently, TET2 knockdown and the overexpression cell models were constructed in ENKTL cell lines. Biochemical analyses were used to assess proliferation, apoptosis, cell cycle and monoclonal formation in cells treated or untreated with L‐Ascorbic acid sodium salt (LAASS). Dot‐Blots were used to detect levels of genome 5mC and 5hmC. Additionally, the ILLUMINA 850k methylation chip was used to analyze the changes of TET2 regulatory genes. RNA‐Seq was used to profile differentially expressed genes regulated by TET2. The global level of 5hmC was significantly decreased, while 5mC was highly expressed in ENKTL tissue. TET2 protein expression was negatively correlated with the ratio of 5mC/5hmC (p < 0.0001). The 5mC/5hmC status were related to the site of disease, clinical stage, PINK score and Ki‐67 index, as well as the 5‐year OS. TET2 knockdown prolonged the DNA synthesis period, increased the cloning ability of tumor cells, increased the level of 5mC and decreased the level of 5hmC in ENKTL cells. While overexpression of TET2 presented the opposite effect. Furthermore, treatment of ENKTL cells with LAASS significantly induced ENKTL cell apoptosis. These results suggest that TET2 plays an important role in ENKTL development via regulation of 5mC and 5hmC and may serve as a novel therapeutic target for ENKTL.
Thirty‐two‐month‐old with multiple duodenal webs diagnosed after failed gastrojejunostomy exchange successfully treated with combination endoscopic therapy
Authors: Tjaden Naomi E. B. , Acord Michael , Minturn Jane , Allukian Myron , Mamula Petar 
Published: July 2024

AbstractIntestinal webs are either congenital or acquired. There are few reported cases of either chemotherapy or nonsteroidal anti‐inflammatory medications leading to acquired intestinal webs in adults. There are limited descriptions of endoscopic interventions used for therapy of numerous duodenal webs in pediatrics. Here, we describe a 32‐month‐old patient undergoing chemotherapy who had multiple duodenal webs. The patient was diagnosed after failed gastrojejunostomy tube exchange via atypical contrast filling pattern and direct visualization with endoscopy. This patient likely has acquired duodenal webs from the combination of nonsteroidal anti‐inflammatory drug containing chemotherapy treatment and repeated tube trauma. Treatment involved serial esophagogastroduodenoscopy with a combination of endoscopic therapy including balloon dilation and incisional therapy with insulated‐tip knife and cautery scissors. The patient now tolerates G‐tube feedings.
The Effect of Co‐Delivery of Oxygen and Anticancer Drugs on the Viability of Healthy and Cancer Cells under Normoxic and Hypoxic Conditions
Authors: Kehr Nermin Seda 
Published: July 2024

AbstractHypoxia, cancer, tissue damage, and acidic pH conditions are interrelated, as chronic hypoxic conditions enhance the malignant phenotype of cancer cells, causing more aggressive tissue destruction, and hypoxic cells rely on anaerobic glycolysis, leading to the accumulation of lactic acid. Therefore, the administration of oxygen is necessary to support the functions of healthy cells until the formation of new blood vessels and to increase the oxygen supply to cancerous tissues to improve the efficacy of antitumor drugs on tumor cells. In addition to O2 supply, pH‐dependent delivery of anticancer drugs is desired to target cancer cells and reduce drug side effects on healthy cells. However, the simultaneous delivery of O2 and pH‐dependent anticancer drugs via nanomaterials and their effects on the viability of normal and cancer cells under hypoxic conditions have not been studied in sufficient numbers. This study describes the synthesis of a pH‐responsive nanomaterial containing oxygen and anticancer drugs that exhibits sustained O2 release over a 14 d period under hypoxic conditions and pH‐dependent sustained release of anticancer drugs over 30 d. The simultaneous administration of O2 and anticancer drugs results in higher cell survival of normal cells than that of cancer cells under hypoxic and normoxic conditions.
Influence of water vapor concentration on photoacoustic spectroscopy‐based characteristic gas analysis of transformer faults
Authors: Mo Bingyu , Zhou Shanghu , Han Menglong , Xie Pengsheng , Li Chenxi , Han Xiao , Qu Quanlei , Li Jianwu , Chen Ke 
Published: July 2024

AbstractThe water vapor in the ambient air affects the accuracy of the photoacoustic (PA) dissolved gas analysis system for transformer health monitoring. A laser PA system was evaluated by dry and humidified standard gases to study the influence of water vapor concentration on PA gas detection. Theoretical analysis was conducted on the effect of gas molecule relaxation on PA signal detection. A high‐frequency resonant PA cell and a low‐frequency nonresonant PA cell were used to detect acetylene (C2H2) and carbon monoxide (CO), respectively. The experimental results show that the PA signal of humidified CO is about 12 times higher than PA signal of dry gas for the resonant PA detection system, respectively. In addition, as the frequency is increased from 30 to 980 Hz, the PA signals of humidified and dry CO attenuate by 1.5 and 6.9 times, respectively.
Zeptosecond‐Scale Single‐Photon Gyroscope
Authors: Sgobba Fabrizio , Triggiani Danilo , Tamma Vincenzo , De Natale Paolo , Gagliardi Gianluca , Avino Saverio , Santamaria Amato Luigi 
Published: July 2024

AbstractThis work presents an all‐fiber telecom‐range optical gyroscope employing a spontaneous parametric down conversion crystal to produce ultra‐low intensity thermal light by tracing‐out one of the heralded photons. The prototype exhibits a detection limit on photon delay measurements of 249 zs over a 72 s averaging time and 26 zs in differential delay measurements at s averaging. The detection scheme proves to be the most resource‐efficient possible, saturating of the Cramér–Rao bound. These results are groundbreaking in the context of low‐photon regime quantum metrology, paving the way to novel experimental configurations to bridge quantum optics with special or general relativity.
A complete shortest independent loop set algorithm for model structure analysis
Authors: Middleton Serafina , Motamed Mohammad 
Published: July 2024

AbstractThis article looks at the well‐known shortest independent loop set algorithm, which is used to identify an independent loop set in system dynamics models. It addresses the cases where the algorithm fails to find a complete set due to its limitation to geodetic cycles and introduces a modification that has the potential to identify a complete independent loop set in every case while maintaining the efficiency of the original algorithm. The modified algorithm uses second‐shortest paths to complete the loop set. Special attention is given to the creation of the second‐shortest path matrix required for the modified algorithm, and to the application of the algorithm to a model where the independent loop set created by the shortest independent loop set algorithm was previously shown to be incomplete. © 2024 System Dynamics Society.
Clinical, magnetic resonance imaging and computed tomography imaging findings in a young cat with epidural pyogranulomatous steatitis
Authors: Martinez Ana , Mortier Jeremy , Gonçalves Rita , Ricci Emanuele , Alcoverro Emili 
Published: July 2024

AbstractA 4‐month‐old male domestic shorthair cat with a 36‐h history of acute and progressive painful paraplegia was referred. The neurological examination was consistent with T3‒L3 myelopathy. Magnetic resonance imaging of the thoracolumbar region revealed an extradural mass at the level of T12‒T13 that caused moderate spinal cord compression. The cat underwent T12‒T13 dorsal laminectomy decompressive surgery, and its neurological signs improved shortly after surgery. A diagnosis of epidural spinal steatitis was reached based on histopathological examination of the compressive mass. To the authors’ best knowledge, this is the first description of the magnetic resonance imaging and computed tomographic findings of histopathologically confirmed idiopathic sterile pyogranulomatous inflammation of epidural fat in a cat. Epidural idiopathic sterile pyogranulomatous steatitis should be included as a possible differential diagnosis in young cats with acute and progressive T3‒L3 myelopathy signs.