bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pharmacologic Treatment Reduces Pressure Times Time Dose and Relative Duration of Intracranial Hypertension
Authors: Colton Katharine , Yang S. , Hu P. F. , Chen H. H. , Bonds B. , Stansbury L. G. , Scalea T. M. , Stein D. M. 
Published: October 2014

Introduction: Past work has shown the importance of the “pressure times time dose” (PTD) of intracranial hypertension (intracranial pressure [ICP] > 19 mm Hg) in predicting outcome after severe traumatic brain injury. We used automated data collection to measure the effect of common medications on the duration and dose of intracranial hypertension. Methods: Patients >17 years old, admitted and requiring ICP monitoring between 2008 and 2010 at a single, large urban tertiary care facility, were retrospectively enrolled. Timing and dose of ICP-directed therapy were recorded from paper and electronic medical records. The ICP data were collected automatically at 6-second intervals and averaged over 5 minutes. The percentage of time of intracranial hypertension (PTI) and PTD (mm Hg h) were calculated. Results: A total of 98 patients with 664 treatment instances were identified. Baseline PTD ranged from 27 (before administration of propofol and fentanyl) to 150 mm Hg h (before mannitol). A “small” dose of hypertonic saline (HTS; ≤250 mL 3%) reduced PTD by 38% in the first hour and 37% in the second hour and reduced the time with ICP >19 by 38% and 39% after 1 and 2 hours, respectively. A “large” dose of HTS reduced PTD by 40% in the first hour and 63% in the second (PTI reduction of 36% and 50%, respectively). An increased dose of propofol or fentanyl infusion failed to decrease PTD but reduced PTI between 14% (propofol alone) and 30% (combined increase in propofol and fentanyl, after 2 hours). Barbiturates failed to decrease PTD but decreased PTI by 30% up to 2 hours after administration. All reductions reported are significantly changed from baseline, P < .05. Conclusion: Baseline PTD values before drug administration reflects varied patient criticality, with much higher values seen before the use of mannitol or barbiturates. Treatment with HTS reduced PTD and PTI burden significantly more than escalation of sedation or pain management, and this effect remained significant at 2 hours after administration.
Le tropisme russe de la chanson française de la Libération à l’effondrement du bloc soviétique
Authors: Francfort Didier 
Published: October 2014

Résumé En pleine période de Guerre Froide, la société française se construit en chanson une image originale de la Russie Soviétique, mêlant stéréotypes, volonté politique de dépasser la logique des blocs, nostalgie des familles d’émigrés. La quantité importante de « chansons russes » françaises culmine dans les années 1960. On retrouve des caractéristiques musicales et des thèmes communs, quelle que soit l’orientation politique des auteurs, compositeurs et interprètes.
Relational interactions preserving dignity experience
Authors: Tranvåg Oscar , Petersen Karin Anna , Nåden Dagfinn 
Published: October 2014

Background: Dignity experience in the daily lives of people living with dementia is influenced by their relational interactions with others. However, literature reviews show that knowledge concerning crucial interactional qualities, preserving their sense of dignity, is limited. Aim: The aim of this study was to explore and describe crucial qualities of relational interactions preserving dignity experience among people with dementia, while interacting with family, social network, and healthcare professionals. Methodology: The study was founded upon Gadamer’s philosophical hermeneutics, and an exploratory design employing qualitative research interviews was conducted. Participants and research context: A total of 11 individuals diagnosed with mild to moderate dementia, living in their own homes, were recruited from two Hospital Memory Clinics in Norway. Ethical considerations: In recruiting persons with dementia as study participants, sensitivity toward their life history, autonomy, integrity, relationships, and dignity is essential. These standards, and the ethical principles of moral sensitivity to their vulnerability, doing no harm, showing justice, and respecting their personal utility, guided our research. Results: Three main interactional qualities preserving the participants’ dignity experience were found: Experiencing love and confirmation; experiencing social inclusion and fellowship; experiencing humane warmth and understanding within a caring culture, while being met as an equal human being. A total of 10 sub-qualities were identified within these 3 main qualities. Discussion and final considerations: Dignity experience among the participants was preserved when certain interactional qualities were present in their interactions with family, social network, and healthcare professionals. While supporting some of the findings of previous studies, this study adds new knowledge on the subject. Knowledge of relational interactions toward preserving dignity experience should be a fundamental part of future dementia care practice. Based on the results of this study, an empirical–theoretical model was developed for this purpose.
Perspectives on the Mental Health Act 2014 (Vic)
Authors: Cross Hannah , Rauchberger Ilan , Kulkarni Jayashri 
Published: October 2014

Objective: This article will consider the potential impact of Victoria’s new Mental Health Act 2014 (Vic) from the perspectives of consumers, careers and members of the treating team. This article will examine how some of the more drastic legal reforms will impact clinical processes, procedures and decision making. Conclusions: The new Act takes significant steps towards empowering consumers. However, its practical application will take some time to appraise. Only time will reveal how the Mental Health Tribunal handles its newfound powers, whether consumers will benefit from a more collaborative approach to clinical decision making and ultimately whether the Act will empower consumers.
Minimal important changes and differences in elective hand surgery
Authors: Rodrigues J. N. , Mabvuure N. T. , Nikkhah D. , Shariff Z. , Davis T. R. C. 
Published: October 2014

Minimal important changes and differences describe the smallest changes and differences between individuals that are relevant to patients following treatment. Minimal important differences may vary between conditions, treatments and lengths of follow-up, and can be calculated in different ways. Minimal important differences for elective hand surgery were reviewed. A total of 99 minimal important differences were identified in 29 articles. The conditions, treatments, outcome measures used and follow-up periods are discussed. The Disabilities of the Arm, Shoulder and Hand had the most estimates of minimal important differences, but these varied. The methods used in the included studies were reviewed and appraised. Most minimal important differences were calculated using retrospective anchors. Future research directions in this area are suggested. Level of evidence: II
Social capital and health: implication for health promotion by lay citizens in Japan
Authors: Miyamoto Keiko , Iwakuma Miho , Nakayama Takeo 
Published: October 2014

A non-profit organization was formed in 2009 by lay citizens of Nagahama, Japan in response to a community-based genome-epidemiologic study, the ‘Nagahama Zero(0)-ji Prevention Cohort Project (N0PCP)’. This organization aims to promote health by taking advantage of citizens’ social networks. The Ottawa Charter for Health Promotion affirms the importance of creating supportive environments and coordinating social relationships. Supportive environments (infrastructure) and social relationships (resources) work together as aspects of social capital. This study sought to examine the association between self-rated health and social capital, at both individual and neighborhood levels, and to discuss suitable health promotion strategies for local circumstances. A cross-sectional survey was conducted in 2011, using a self-administered postal questionnaire. Social capital indicators included aspects of support in the environment (social support, neighborhood connectedness, informal social controls, neighborhood trust, general trust, and attachment to place) and social relationships (number of activities; participation in neighborhood activities; participation in recreational activities; and social leverage regarding physical health, mental health, and acquisition of health information). Neighborhood-level social capital was calculated as the percentage of individuals in a neighborhood in the ‘high social capital’ category. At the individual level, participation in recreational activities, high general trust, and discussion regarding mental health problems with family members were associated with self-rated health positively, whereas discussion of mental health problems with acquaintances had a negative correlation. At the neighborhood level, a highly supportive environment did not contribute to good health, whereas aggregated attachment to place had a positive correlation. There were no significant inter-regional health differences. The results of this study suggest that health promotion activities should aim at promoting the formation of empathetic friendships through individual networks, based on bringing individuals who need support to compatible places. Attachment to place should be incorporated into activities as an important and effective tool.
Inhibiting CARD11 translation during BCR activation by targeting the eIF4A RNA helicase
Authors: Steinhardt James J. , Peroutka Raymond J. , Mazan-Mamczarz Krystyna , Chen Qing , Houng Simone , Robles Carol , Barth Rolf N. , DuBose Joseph , Bruns Brandon , Tesoriero Ronald , Stein Deborah , Fang Raymond , Hanna Nader , Pasley Jason , Rodriguez Carlos , Kligman Mark D. , Bradley Matthew , Rabin Joseph , Shackelford Stacy , Dai Bojie , Landon Ari L. , Scalea Thomas , Livak Ferenc , Gartenhaus Ronald B. 
Published: October 2014

Key PointsBCR activation enhances eIF4A m7GTP cap-binding. The 5′UTR of CARD11 suppresses protein translation.
Management and clinical outcomes in patients treated with apixaban vs warfarin undergoing procedures
Authors: Garcia David , Alexander John H. , Wallentin Lars , Wojdyla Daniel M. , Thomas Laine , Hanna Michael , Al-Khatib Sana M. , Dorian Paul , Ansell Jack , Commerford Patrick , Flaker Greg , Lanas Fernando , Vinereanu Dragos , Xavier Denis , Hylek Elaine M. , Held Claes , Verheugt Freek W. A. , Granger Christopher B. , Lopes Renato D. 
Published: October 2014

Key Points
Short-term preprocedure interruptions of either apixaban or warfarin are associated with a low rate of stroke or systemic embolism. Some patients taking apixaban or warfarin are able to undergo procedures safely without a preprocedure interruption of anticoagulation.
Schur-geometric convexity of the generalized Gini-Heronian means involving three parameters
Authors: Deng Yong-Ping , Chu Yu-Ming , Wu Shan-He , Debnath Lokenath , He Deng 
Published: October 2014

Abstract
In this paper, we give a unified generalization of the Gini means and Heronian means. The Schur-geometric convexity of the generalized Gini-Heronian means are investigated. Our result generalizes an earlier result given by Shi et al. (J. Inequal. Appl. 2008:879273, 2008). At the end of the paper, two new inequalities related to the generalized Gini-Heronian means are established to illustrate the applicability of the given result.

MSC:26D15, 26E60, 26A51.
Multi-step iterative algorithms with regularization for triple hierarchical variational inequalities with constraints of mixed equilibria, variational inclusions, and convex minimization
Authors: Ceng Lu-Chuan , Wen Ching-Feng , Liou Cheng 
Published: October 2014

Abstract
In this paper, we introduce and analyze a relaxed iterative algorithm by virtue of Korpelevich’s extragradient method, the viscosity approximation method, the hybrid steepest-descent method, the regularization method, and the averaged mapping approach to the gradient-projection algorithm. It is proven that under appropriate assumptions, the proposed algorithm converges strongly to a common element of the fixed point set of infinitely many nonexpansive mappings, the solution set of finitely many generalized mixed equilibrium problems (GMEPs), the solution set of finitely many variational inclusions and the set of minimizers of convex minimization problem (CMP), which is just a unique solution of a triple hierarchical variational inequality (THVI) in a real Hilbert space. In addition, we also consider the application of the proposed algorithm to solving a hierarchical fixed point problem with constraints of finitely many GMEPs, finitely many variational inclusions, and CMP. The results obtained in this paper improve and extend the corresponding results announced by many others.

MSC:49J30, 47H09, 47J20, 49M05.
Year in review 2013: Critical Care- nephrology
Authors: Ricci Zaccaria , Di Nardo Matteo , Ronco Claudio 
Published: October 2014

AbstractWe review original research in the field of critical care nephrology accepted or published in 2013 in Critical Care and, when considered relevant or linked to these studies, in other journals. Three main topics have been identified and are discussed for a rapid overview: acute kidney injury (diagnosis, risk factors and outcome); timing and modality of renal replacement therapy; and extracorporeal membrane oxygenation and renal dysfunction.
Genome-wide profiling of mouse RNA secondary structures reveals key features of the mammalian transcriptome
Authors: Incarnato Danny , Neri Francesco , Anselmi Francesca , Oliviero Salvatore 
Published: October 2014

Abstract
Background
The understanding of RNA structure is a key feature toward the comprehension of RNA functions and mechanisms of action. In particular, non-coding RNAs are thought to exert their functions by specific secondary structures, but an efficient annotation on a large scale of these structures is still missing.

Results
By using a novel high-throughput method, named chemical inference of RNA structures, CIRS-seq, that uses dimethyl sulfate, and N-cyclohexyl- N'-(2-morpholinoethyl)carbodiimide metho-p-toluenesulfonate to modify RNA residues in single-stranded conformation within native deproteinized RNA secondary structures, we investigate the structural features of mouse embryonic stem cell transcripts. Our analysis reveals an unexpected higher structuring of the 5′ and 3′ untranslated regions compared to the coding regions, a reduced structuring at the Kozak sequence and stop codon, and a three-nucleotide periodicity across the coding region of messenger RNAs. We also observe that ncRNAs exhibit a higher degree of structuring with respect to protein coding transcripts. Moreover, we find that the Lin28a binding protein binds selectively to RNA motifs with a strong preference toward a single stranded conformation.

Conclusions
This work defines for the first time the complete RNA structurome of mouse embryonic stem cells, revealing an extremely distinct RNA structural landscape. These results demonstrate that CIRS-seq constitutes an important tool for the identification of native deproteinized RNA structures.
Transcriptomic analysis reveals tomato genes whose expression is induced specifically during effector-triggered immunity and identifies the Epk1 protein kinase which is required for the host response to three bacterial effector proteins
Authors: Pombo Marina A , Zheng Yi , Fernandez-Pozo Noe , Dunham Diane M , Fei Zhangjun , Martin Gregory B 
Published: October 2014

Abstract
Background
Plants have two related immune systems to defend themselves against pathogen attack. Initially, pattern-triggered immunity is activated upon recognition of microbe-associated molecular patterns by pattern recognition receptors. Pathogenic bacteria deliver effector proteins into the plant cell that interfere with this immune response and promote disease. However, some plants express resistance proteins that detect the presence of specific effectors leading to a robust defense response referred to as effector-triggered immunity. The interaction of tomato with Pseudomonas syringae pv. tomato is an established model system for understanding the molecular basis of these plant immune responses.

Results
We apply high-throughput RNA sequencing to this pathosystem to identify genes whose expression changes specifically during pattern-triggered or effector-triggered immunity. We then develop reporter genes for each of these responses that will enable characterization of the host response to the large collection of P. s. pv. tomato strains that express different combinations of effectors. Virus-induced gene silencing of 30 of the effector-triggered immunity-specific genes identifies Epk1 which encodes a predicted protein kinase from a family previously unknown to be involved in immunity. Knocked-down expression of Epk1 compromises effector-triggered immunity triggered by three bacterial effectors but not by effectors from non-bacterial pathogens. Epistasis experiments indicate that Epk1 acts upstream of effector-triggered immunity-associated MAP kinase signaling.

Conclusions
Using RNA-seq technology we identify genes involved in specific immune responses. A functional genomics screen led to the discovery of Epk1, a novel predicted protein kinase required for plant defense activation upon recognition of three different bacterial effectors.
Modules, networks and systems medicine for understanding disease and aiding diagnosis
Authors: Gustafsson Mika , Nestor Colm E , Zhang Huan , Barabási Albert-László , Baranzini Sergio , Brunak Sören , Chung Kian Fan , Federoff Howard J , Gavin Anne-Claude , Meehan Richard R , Picotti Paola , Pujana Miguel Ángel , Rajewsky Nikolaus , Smith Kenneth GC , Sterk Peter J , Villoslada Pablo , Benson Mikael 
Published: October 2014

AbstractMany common diseases, such as asthma, diabetes or obesity, involve altered interactions between thousands of genes. High-throughput techniques (omics) allow identification of such genes and their products, but functional understanding is a formidable challenge. Network-based analyses of omics data have identified modules of disease-associated genes that have been used to obtain both a systems level and a molecular understanding of disease mechanisms. For example, in allergy a module was used to find a novel candidate gene that was validated by functional and clinical studies. Such analyses play important roles in systems medicine. This is an emerging discipline that aims to gain a translational understanding of the complex mechanisms underlying common diseases. In this review, we will explain and provide examples of how network-based analyses of omics data, in combination with functional and clinical studies, are aiding our understanding of disease, as well as helping to prioritize diagnostic markers or therapeutic candidate genes. Such analyses involve significant problems and limitations, which will be discussed. We also highlight the steps needed for clinical implementation.
Using genetically isolated populations to understand the genomic basis of disease
Authors: Zeggini Eleftheria 
Published: October 2014

AbstractRare variation has a key role in the genetic etiology of complex traits. Genetically isolated populations have been established as a powerful resource for novel locus discovery and they combine advantageous characteristics that can be leveraged to expedite discovery. Genome-wide genotyping approaches coupled with sequencing efforts have transformed the landscape of disease genomics and highlight the potentially significant contribution of studies in founder populations.
Low Testosterone Concentration and Atherosclerotic Disease Markers in Male Patients With Type 2 Diabetes
Authors: Farias Javier M. , Tinetti Matias , Khoury Marina , Umpierrez Guillermo E. 
Published: October 2014

Background:
Low total T is associated with an increased risk of atherosclerotic complications. However, the magnitude of this association in middle-aged patients with type 2 diabetes (T2D) has not been determined.

Materials and Methods:
This cross-sectional study evaluated atherosclerotic disease markers in T2D patients with normal and low plasma total T. A total of 115 male patients, aged younger than 70 years, without a history of cardiovascular events, and with normal [≥3.5 ng/mL (≥12.1 nmol/L), n = 79] or low [&lt; 3.5 ng/mL (≤12.1 nmol/L), n = 36] total T underwent the measurement of highly sensitive C-reactive protein, carotid artery carotid intima-media thickness (IMT), and atherosclerotic plaque by high-resolution B-mode ultrasound and to asses endothelial function by brachial artery flow-mediated dilation.

Results:
Carotid IMT was negatively correlated with total T concentration (r = −0.39, P &lt; .0001). Compared with subjects with normal T, a higher proportion of patients with low total T had carotid IMT of 0.1 cm or greater [80% vs 39%, odds ratio (OR) 6.41; 95% CI 2.5–16.4, P &lt; .0001], atherosclerotic plaques (68.5% vs 44.8%, OR 2.60, 95% CI 1.12–6.03, P &lt; .0001); endothelial dysfunction (80.5% vs 42.3%, OR 5.77, 95% CI 2.77–14.77, P &lt; .003), and higher highly sensitive C-reactive protein levels (2.74 ± 5.82 vs 0.89 ± 0.88 mg/L, P &lt; .0001). Similar results were found when free T was considered. Multiple logistic regression analyses adjusted for age, diabetes mellitus duration, hemoglobin A1c, lipids, treatment effect, and body mass index reported that a low total T level was independently associated with greater IMT [OR 8.43 (95% CI 2.5–25.8)] and endothelial dysfunction [OR 5.21 (95% CI 1.73–15.66)] but not with the presence of atherosclerotic plaques (OR 1.77, 95% CI 0.66–4.74).

Conclusions:
Low T is associated with more advanced atherosclerotic disease markers in middle-aged patients with T2D.
Institutional management of Сomplex economic systems
Authors: Толкачев  , Tolkachev S. , Тепляков  , Teplyakov A. 
Published: October 2014

Methodological aspects of interrelation between economic science mainstream fundamentals and modern
complex systems management issues are considered in this paper. It has been shown that mainstream’s
ontology had been adopted in the early of the twentieth century from those natural sciences branches which
studied noncomplex systems. Non-ergodic nature of modern economic world is proved. The features of the
modern complex systems management are disclosed. Need of transition to institutional management of
complex systems is justified.
Intellectual Capital Management in High-Tech Companies
Authors: Беленькая  , Belenkaya N. , Першуков  , Pershukov V. 
Published: October 2014

Formation of any innovation system assumes the availability of infrastructure to bring each created design to
the final consumer and transform ideas, knowledge and competencies in the money. Main approaches and
tools for intellectual capital managing on the example of the State Atomic Energy Corporation &#34;Rosatom&#34;
have been considered in this paper.