bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improvement of Sleep Disturbance and Insomnia Following Parathyroidectomy for Primary Hyperparathyroidism
Authors: Murray Sara E. , Pathak Priya R. , Schaefer Sarah C. , Chen Herbert , Sippel Rebecca S. 
Published: October 2013

AbstractBackgroundThe aim of the present study was to investigate the incidence of sleep disturbance and insomnia in patients with primary hyperparathyroidism (PHPT), and to evaluate the effect of parathyroidectomy.MethodsA questionnaire was prospectively administered to adult patients with PHPT who underwent curative parathyroidectomy over an 11‐month period. The questionnaire, administered preoperatively and 6 months postoperatively, included the Insomnia Severity Index (ISI) and eight additional questions regarding sleep pattern. Total ISI scores range from 0 to 28, with >7 signifying sleep difficulties and scores >14 indicating clinical insomnia.ResultsOf 197 eligible patients undergoing parathyroidectomy for PHPT, 115 (58.3 %) completed the preoperative and postoperative questionnaires. The mean age was 60.0 ± 1.2 years and 80.0 % were women. Preoperatively, 72 patients (62.6 %) had sleep difficulties, and 29 patients (25.2 %) met the criteria for clinical insomnia. Clinicopathologic variables were not predictive of clinical insomnia. There was a significant reduction in mean ISI score after parathyroidectomy (10.3 ± 0.6 vs 6.2 ± 0.5, p < 0.0001). Postoperatively, 79 patients (68.7 %) had an improved ISI score. Of the 29 patients with preoperative clinical insomnia, 21 (72.4 %) had resolution after parathyroidectomy. Preoperative insomnia patients had an increase in total hours slept after parathyroidectomy (5.4 ± 0.3 vs 6.1 ± 0.3 h, p = 0.02), whereas both insomnia patients and non‐insomnia patients had a decrease in the number of awakenings (3.7 ± 0.4 vs 1.9 ± 0.2 times, p = 0.0001).ConclusionsSleep disturbances and insomnia are common in patients with PHPT, and the majority of patients will improve after curative parathyroidectomy.
Prospecting genomes for lasso peptides
Authors: Maksimov Mikhail O , Link A James 
Published: October 2013

Abstract
Genome mining has unlocked a veritable treasure chest of natural compounds. However, each family of natural products requires a genome-mining approach tailored to its unique features to be successful. Lasso peptides are ribosomally synthesized and posttranslationally modified products with a unique three-dimensional structure. Advances in the understanding of these molecules have informed the design of strategies to identify new members of the class in sequenced genomes. This review presents the bioinformatic methods used to discover novel lasso peptides and describes how such analyses have afforded insights into the biosynthesis and evolution of this peptide class.
Potential role of vitamin D deficiency on Fabry cardiomyopathy
Authors: Drechsler Christiane , Schmiedeke Benjamin , Niemann Markus , Schmiedeke Daniel , Krämer Johannes , Turkin Irina , Blouin Katja , Emmert Andrea , Pilz Stefan , Obermayer‐Pietsch Barbara , Weidemann Frank , Breunig Frank , Wanner Christoph 
Published: October 2013

AbstractPatients with Fabry disease frequently develop left ventricular (LV) hypertrophy and renal fibrosis. Due to heat intolerance and an inability to sweat, patients tend to avoid exposure to sunlight. We hypothesized that subsequent vitamin D deficiency may contribute to Fabry cardiomyopathy. This study investigated the vitamin D status and its association with LV mass and adverse clinical symptoms in patients with Fabry disease. 25‐hydroxyvitamin D (25[OH]D) was measured in 111 patients who were genetically proven to have Fabry disease. LV mass and cardiomyopathy were assessed by magnetic resonance imaging and echocardiography. In cross‐sectional analyses, associations with adverse clinical outcomes were determined by linear and binary logistic regression analyses, respectively, and were adjusted for age, sex, BMI and season. Patients had a mean age of 40 ± 13 years (42 % males), and a mean 25(OH)D of 23.5 ± 11.4 ng/ml. Those with overt vitamin D deficiency (25[OH]D ≤ 15 ng/ml) had an adjusted six fold higher risk of cardiomyopathy, compared to those with sufficient 25(OH)D levels >30 ng/ml (p = 0.04). The mean LV mass was distinctively different with 170 ± 75 g in deficient, 154 ± 60 g in moderately deficient and 128 ± 58 g in vitamin D sufficient patients (p = 0.01). With increasing severity of vitamin D deficiency, the median levels of proteinuria increased, as well as the prevalences of depression, edema, cornea verticillata and the need for medical pain therapy. In conclusion, vitamin D deficiency was strongly associated with cardiomyopathy and adverse clinical symptoms in patients with Fabry disease. Whether vitamin D supplementation improves complications of Fabry disease, requires a randomized controlled trial.
Recovery of Sinapic Acid from the Waste Effluent of Mustard Protein Isolation by Ion Exchange Chromatography
Authors: Prapakornwiriya N. , Diosady L. L. 
Published: October 2013

AbstractSinapic acid present in the waste stream of yellow mustard protein isolation was purified by strong base Dowex (1 × 8, Cl−) ion exchange chromatography. The ratio of loading volume to resin bed volume was 19:1. Approximately 80 % of sinapic acid was adsorbed. The column was washed with two bed volumes of water to remove remaining undesirable components. Approximately 75 % of sinapic acid adsorbed by the resins in the column was eluted by ten bed volumes of a solution containing 0.9 M acetic acid and methanol (4:6, v/v). Up to 15 adsorption and regeneration cycles resulted in only a slight, 3–5 %, reduction in ion exchange capacity, indicating that this is a viable approach to the recovery and purification of sinapic acid. The recovery of this valuable nutraceutical ingredient improves the economic viability of an integrated extraction process for this Canadian oilseed crop.
„La filiation est directe“ Der Einfluss von Marcel Mauss auf das Werk von Claude Lévi-Strauss
Authors: Moebius Stephan , Nungesser Frithjof 
Published: October 2013

AbstractThe paper argues that Claude Lévi-Strauss’ thought was influenced by Marcel Mauss’ works in a much deeper way than has been remarked in the literature. Far from being restricted to Lévi-Strauss’ seminal 1949 work onThe Elementary Structures of KinshipMauss’ constitutive impact can already be found in Lévi-Strauss’ early ethnographic studies (starting in the mid-1930s). Moreover, it can be shown that decisive theses and arguments of Lévi-Strauss’ later thought – ranging from the anthropology of kinship to classification theory and the specifics of the “savage mind” – are clearly prefigured in these early texts. In the end, the arguments presented here do not only call into question the well-known and widespread portrayal of Lévi-Strauss as a solitary scientist and “born structuralist” but also show how the specific interpretation of Mauss by Lévi-Strauss directed and restricted the further reception of Mauss’ works.
The Impact Factor Fetishism
Authors: Fleck Christian 
Published: October 2013

AbstractOne of the most popular indicators is the Impact Factor. This paper examines the coming into being of this highly influential figure. It is the offspring of Eugene Garfield’s experimentation with the huge amounts of data available at his Institute for Scientific Information and the result of a number of attempts to find appropriate measurements for the success (“impact”) of articles and journals. The completely inductive procedure was initially adjusted by examining the data thoughtfully and by consulting with experts from different scientific disciplines. Later, its calculation modes were imposed on other disciplines without further consideration. The paper demonstrates in detail the inopportune consequences of this, in particular for sociology. Neither the definition of disciplines, nor the selection of journals for the Web of Science/Social Science Citation Index follows any comprehensible rationale. The procedures for calculating the impact factor are inappropriate. Despite its obvious unsuitability, the impact factor is used by editors of sociological journals for marketing and impression management purposes. Fetishism!
A sixteenth-century Neoplatonic synthesis: Francesco Piccolomini's theory of mathematics and imagination in theAcademicae contemplationes
Authors: CLAESSENS GUY 
Published: October 2013

AbstractThe metamathematical framework of the early modern period is primarily determined by two presuppositions stemming from the Aristotelian tradition: (1) mathematical objects are abstracted from sensible matter; (2) imagination is a reproductive faculty exclusively connected with the sensible realm. The recovery of the works of the Greek commentators confronted the early modern readers with rivalling philosophical–mathematical views that explicitly called into question some of their previously undisputed assumptions. In this article I will argue that Francesco Piccolomini (1523–1607) in hisAcademicae contemplationesbrings about an original fusion of these colliding horizons, by transposing the synthesis established by (?)Simplicius between Aristotelian abstractionism and Neoplatonic innatism into the sixteenth century.
Mineral ages and zircon Hf isotopic composition of the Andong ultramafic complex: implications for the evolution of Mesozoic subduction system and subcontinental lithospheric mantle beneath SE Korea
Authors: JEONG GI YOUNG , CHEONG CHANG-SIK , YI KEEWOOK , KIM JEONGMIN , KIM NAMHOON , KWON SEOK-KI , GENG JIAN-ZHEN , LI HUAI-KUN 
Published: October 2013

AbstractThe Phanerozoic subduction system of the Korean peninsula is considered to have been activated by at least Middle Permian time. The geochemically arc-like Andong ultramafic complex (AUC) occurring along the border between the Precambrian Yeongnam massif and the Cretaceous Gyeongsang back-arc basin provides a rare opportunity for direct study of the pre-Cretaceous mantle wedge lying above the subduction zone. The tightly constrained SHRIMP U–Pb age of zircons extracted from orthopyroxenite specimens (222.1±1.0 Ma) is indistinguishable from the Ar/Ar age of coexisting phlogopite (220±6 Ma). These ages represent the timing of suprasubduction zone magmatism likely in response to the sinking of cold and dense oceanic lithosphere and the resultant extensional strain regime in a nascent arc environment. The nearly coeval occurrence of a syenite-gabbro-monzonite suite in the SW Yeongnam massif also suggests an extensional tectonic setting along the continental margin side during Late Triassic time. The relatively enriched ɛHf range of dated zircons (+6.2 to −0.6 at 222 Ma) is in contrast to previously reported primitive Sr–Nd–Hf isotopic features of Cenozoic mantle xenoliths from Korea and eastern China. This enrichment is not ascribed to contamination by the hypothetical Palaeozoic crust beneath SE Korea, but is instead attributable to metasomatism of the lithospheric mantle during the earlier subduction of the palaeo-Pacific plate. Most AUC zircons show a restricted core-to-rim spread of ɛHf values, but some grains testify to the operation of open-system processes during magmatic differentiation.
Whole transcriptome analysis of the poultry red mite Dermanyssus gallinae (De Geer, 1778)
Authors: SCHICHT SABINE , QI WEIHONG , POVEDA LUCY , STRUBE CHRISTINA 
Published: October 2013

SUMMARYAlthough the poultry red mite Dermanyssus gallinae (De Geer, 1778) is the major parasitic pest in poultry farming causing substantial economic losses every year, nucleotide data are rare in the public databases. Therefore, de novo sequencing covering the transcriptome of D. gallinae was carried out resulting in a dataset of 232 097 singletons and 42 130 contiguous sequences (contigs) which were subsequently clustered into 24 140 isogroups consisting of 35 788 isotigs. After removal of sequences possibly originating from bacteria or the chicken host, 267 464 sequences (231 657 singletons, 56 contigs and 35 751 isotigs) remained, of which 10·3% showed homology to proteins derived from other organisms. The most significant Blast top-hit species was the mite Metaseiulus occidentalis followed by the tick Ixodes scapularis. To gain functional knowledge of D. gallinae transcripts, sequences were mapped to Gene Ontology terms, Kyoto Encyclopedia of Gene and Genomes (KEGG) pathways and parsed to InterProScan. The transcriptome dataset provides new insights in general mite genetics and lays a foundation for future studies on stage-specific transcriptomics as well as genomic, proteomic, and metabolomic explorations and might provide new perspectives to control this parasitic mite by identifying possible drug targets or vaccine candidates. It is also worth noting that in different tested species of the class Arachnida no 28S rRNA was detectable in the rRNA profile, indicating that 28S rRNA might consists of two separate, hydrogen-bonded fragments, whose (heat-induced) disruption may led to co-migration with 18S rRNA.
‘Will make a good Admiral’: a reassessment of Captain Scott's naval career
Authors: Lewis George , May Karen 
Published: October 2013

ABSTRACTIn his book Scott and Amundsen (1979) Roland Huntford described Captain Robert Falcon Scott R.N. as ‘not well thought of in the Service’ and ‘an obscure, rather dull torpedo lieutenant with mediocre prospects’. A myth has subsequently arisen that Scott was forced into Antarctic exploration as his only route to naval promotion. In reality, Scott was an extremely able officer held in high regard by his naval contemporaries; he was on course for promotion to flag rank (rear-admiral and above) had he not taken up polar exploration; and his primary motivation for polar work was financial support for his family. In addition to a chronological account of Scott's career, this article will present his Admirals’ reports in full.
A reuse oriented representation model for capturing and formalizing the evolving design rationale
Authors: Liu Jihong , Hu Xujie 
Published: October 2013

AbstractDesign rationale (DR) explains why an artifact is designed the way it is. An explicit representation of DR is helpful to designers, allowing them to understand, improve, and reuse previous designs. The argumentation-based representation is the mainstream approach to DR representation. It has a semiformal graphical format to depict the structure of arguments for solving a design problem. This paper argues that because the design is not just a problem-solving process but also a cognitive activity that is continuously iterative and evolving, the conventional argumentation-based representation of DR has some inherent limitations. An improved, intent-driven representation model is proposed to capture and formalize the DR and its evolving history to support DR reuse. The model's knowledge structure, consisting of DR elements and their relationships, is detailed. A preliminary knowledge representation of the model based on Web Ontology Language is introduced. Furthermore, the context of DR is defined to document the complete DR and support effective traceability of design thinking. A graphical DR modeling system is developed, and an example is demonstrated to verify the system's application and the effectiveness of the proposed representation model. The paper provides an effective method to retain and manage a designer's implicit design knowledge, which has the potential to significantly improve the integrated management of product development knowledge.
Involvement of l(–)-rhamnose in sea urchin gastrulation: a live embryo assay
Authors: Smith Tiffany N. , Oppenheimer Steven B. 
Published: October 2013

SummaryThe sea urchin embryo is a National Institutes of Health model system that has provided major developments, and is important in human health and disease. To obtain initial insights to identify glycans that mediate cellular interactions, Lytechinus pictus sea urchin embryos were incubated at 24 or 30 h post-fertilization with 0.0009–0.03 M alpha-cyclodextrin, melibiose, l(–)-rhamnose, trehalose, d(+)-xylose or l(–)-xylose in lower-calcium artificial sea water (pH 8.0, 15°C), which speeds the entry of molecules into the interior of the embryos. While α-cyclodextrin killed the embryos, and l(–)-xylose had small effects at one concentration tested, l(–)-rhamnose caused substantially increased numbers of unattached archenterons and exogastrulated embryos at low glycan concentrations after 18–24 h incubation with the sugar. The results were statistically significant compared with the control embryos in the absence of sugar (P < 0.05). The other sugars (melibiose, trehalose, d(+)-xylose) had no statistically significant effects whatsoever at any of the concentrations tested. In total, in the current study, 39,369 embryos were examined. This study is the first demonstration that uses a live embryo assay for a likely role for l(–)-rhamnose in sea urchin gastrula cellular interactions, which have interested investigators for over a century.
Exploring the effectiveness of linguistic knowledge for biographical relation extraction
Authors: GARCIA MARCOS , GAMALLO PABLO 
Published: October 2013

AbstractMachine learning techniques have been implemented to extract instances of semantic relations using diverse features based on linguistic knowledge, such as tokens, lemmas, PoS-tags, or dependency paths. However, there has been little work aiming to know which of these features works better in the relation extraction task, and less in languages other than English. In this paper, various features representing different levels of linguistic knowledge are systematically evaluated for biographical relation extraction. The effectiveness of these features was measured by training several supervised classifiers that only differ in the type of linguistic knowledge used to define their features. The experiments performed in this paper show that some basic linguistic knowledge (provided by lemmas and their combination in bigrams) behaves better than other complex features, such as those based on syntactic analysis. Furthermore, some feature combinations using different levels of analysis are proposed in order (i) to avoid feature overlapping as well as (ii) to evaluate the use of computationally inexpensive and widespread tools such as tokenization and lemmatization. This paper also describes two new freely available corpora for biographical relation extraction in Portuguese and Spanish, built by means of a distant-supervision strategy. Experiments were performed with five semantic relations and two languages, using these corpora.
Involvement of proteinase activated receptor-2in the vascular response to sphingosine 1-phosphate
Authors: Roviezzo Fiorentina , De Angelis Antonella , De Gruttola Luana , Bertolino Antonio , Sullo Nikol , Brancaleone Vincenzo , Bucci Mariarosaria , De Palma Raffaele , Urbanek Konrad , D’Agostino Bruno , Ianaro Angela , Sorrentino Raffaella , Cirino Giuseppe 
Published: October 2013

S1P (sphingosine 1-phosphate) represents one of the key latest additions to the list of vasoactive substances that modulate vascular tone. PAR-2 (proteinase activated receptor-2) has been shown to be involved in cardiovascular function. In the present study, we investigated the involvement of PAR-2 in S1P-induced effect on vascular tone. The present study has been performed by using isolated mouse aortas. Both S1P and PAR-2 agonists induced endothelium-dependent vasorelaxation. L-NAME (NG-nitro-L-arginine methyl ester) and wortmannin abrogated the S1P-induced vasorelaxatioin, while significantly inhibiting the PAR-2-mediated effect. Either ENMD1068, a PAR-2 antagonist, or gabexate, a serine protease inhibitor, significantly inhibited S1P-induced vasorelaxation. Aortic tissues harvested from mice overexpressing PAR-2 displayed a significant increase in vascular response to S1P as opposed to PAR-2-null mice. Immunoprecipitation and immunofluorescence studies demonstrated that S1P1 interacted with PAR-2 and co-localized with PAR-2 on the vascular endothelial surface. Furthermore, S1P administration to vascular tissues triggered PAR-2 mobilization from the plasma membrane to the perinuclear area; S1P-induced translocation of PAR-2 was abrogated when aortic rings were pre-treated with ENMD1068 or when caveolae dysfunction occurred. Similarly, experiments performed in cultured endothelial cells (human umbilical vein endothelial cells) showed a co-localization of S1P1 and PAR2, as well as the ability of S1P to induce PAR-2 trafficking. Our results suggest that S1P induces endothelium-dependent vasorelaxation mainly through S1P1 and involves PAR-2 transactivation.
Cell-cycle regulation of formin-mediated actin cable assembly
Authors: Miao Yansong , Wong Catherine C. L. , Mennella Vito , Michelot Alphée , Agard David A. , Holt Liam J. , Yates John R. , Drubin David G. 
Published: October 2013

Significance
Actin filaments are protein polymers that facilitate multiple biological functions, including cell migration, vesicle trafficking, and polarity establishment in eukaryotic cells throughout the cell cycle. Mechanisms of spatial and temporal regulation of actin assembly in vivo are incompletely understood. Formin proteins nucleate cables, which are bundles of unbranched actin filaments. We developed a cell-extract system to reconstitute actin cable assembly nucleated by formins in a physiological context. Using this unique reconstitution system, we identified an actin cable parts list. We also discovered that actin cable assembly is regulated in a cell-cycle–dependent manner both in vivo and in vitro.
Purification and Characterization of Novel Microtubule-Associated Proteins from Arabidopsis Cell Suspension Cultures
Authors: Hamada Takahiro , Nagasaki-Takeuchi Nahoko , Kato Takehide , Fujiwara Masayuki , Sonobe Seiji , Fukao Yoichiro , Hashimoto Takashi 
Published: October 2013

AbstractPlant microtubules (MTs) play essential roles in cell division, anisotropic cell expansion, and overall organ morphology. Microtubule-associated proteins (MAPs) bind to MTs and regulate their dynamics, stability, and organization. Identifying the full set of MAPs in plants would greatly enhance our understanding of how diverse MT arrays are formed and function; however, few proteomics studies have characterized plant MAPs. Using liquid chromatography-tandem mass spectrometry, we identified hundreds of proteins from MAP-enriched preparations derived from cell suspension cultures of Arabidopsis (Arabidopsis thaliana). Previously reported MAPs, MT regulators, kinesins, dynamins, peroxisome-resident enzymes, and proteins implicated in replication, transcription, and translation were highly enriched. Dozens of proteins of unknown function were identified, among which 12 were tagged with green fluorescent protein (GFP) and examined for their ability to colocalize with MTs when transiently expressed in plant cells. Six proteins did indeed colocalize with cortical MTs in planta. We further characterized one of these MAPs, designated as BASIC PROLINE-RICH PROTEIN1 (BPP1), which belongs to a seven-member family in Arabidopsis. BPP1-GFP decorated interphase and mitotic MT arrays in transgenic Arabidopsis plants. A highly basic, conserved region was responsible for the in vivo MT association. Overexpression of BPP1-GFP stabilized MTs, caused right-handed helical growth in rapidly elongating tissues, promoted the formation of transverse MT arrays, and resulted in the outgrowth of epidermal cells in light-grown hypocotyls. Our high-quality proteome database of Arabidopsis MAP-enriched preparations is a useful resource for identifying novel MT regulators and evaluating potential MT associations of proteins known to have other cellular functions.