bluuebunny/crossref_metadata_2025_split huggingface dataset:
Molecular Mapping of Sinoatrial Node HCN Channel Expression in the Human Heart
Authors: Li Ning , Csepe Thomas A. , Hansen Brian J. , Dobrzynski Halina , Higgins Robert S.D. , Kilic Ahmet , Mohler Peter J. , Janssen Paul M.L. , Rosen Michael R. , Biesiadecki Brandon J. , Fedorov Vadim V. 
Published: August 2015

Background—

The hyperpolarization-activated current,
I
f
, plays an important role in sinoatrial node (SAN) pacemaking. Surprisingly, the distribution of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in human SAN has only been investigated at the mRNA level. Our aim was to define the expression pattern of HCN proteins in human SAN and different atrial regions.

Methods and Results—
Entire SAN complexes were isolated from failing (n=5) and nonfailing (n=9) human hearts cardioplegically arrested in the operating room. Three-dimensional intramural SAN structure was identified as the fibrotic compact region around the SAN artery with Connexin 43–negative pacemaker cardiomyocytes visualized in Masson’s trichrome and immunostained cryosections. SAN protein was precisely isolated from the adjacent frozen SAN tissue blocks using a 16G biopsy needle. The purity of the SAN protein was confirmed by Connexin 43 immunoblot. All 3 HCN isoform proteins were detected in SAN. HCN1 was predominantly distributed in the human SAN with a 125.1±40.2 (n=12) expression ratio of SAN to right atrium. HCN2 and HCN4 expression levels were higher in SAN than in atria, with SAN to right atrium ratios of 6.1±0.9 and 4.6±0.6 (n=12), respectively.

Conclusions—
This is the first study to conduct precise 3D molecular mapping of the human SAN by isolating pure pacemaker SAN tissue. All 3 cardiac HCN isoforms had higher expression in the SAN than in the atria. HCN1 was almost exclusively expressed in SAN, emphasizing its utility as a new specific molecular marker of the human SAN and as a potential target of specific treatments intended to modify sinus rhythm.
Coronary Heart Disease Mortality Declines in the United States From 1979 Through 2011
Authors: Wilmot Kobina A. , O’Flaherty Martin , Capewell Simon , Ford Earl S. , Vaccarino Viola 
Published: August 2015

Background—
Coronary heart disease (CHD) mortality rates have fallen dramatically over the past 4 decades in the Western world. However, recent data from the United States and elsewhere suggest a plateauing of CHD incidence and mortality among young women. We therefore examined recent trends in CHD mortality rates in the United States according to age and sex.

Methods and Results—
We analyzed mortality data between 1979 and 2011 for US adults ≥25 years of age. We calculated age-specific CHD mortality rates and compared estimated annual percentage changes during 3 approximate decades of data (1979–1989, 1990–1999, and 2000–2011). We then used Joinpoint regression modeling to assess changes in trends over time on the basis of inflection points of the mortality rates. Adults ≥65 years of age showed consistent mortality declines, which became even steeper after 2000 (women, −5.0%; men, −4.4%). In contrast, young men and women (<55 years of age) initially showed a clear decline in CHD mortality from 1979 until 1989 (estimated annual percentage change, −5.5% in men and −4.6% in women). However, the 2 subsequent decades saw stagnation with minimal improvement. Notably, young women demonstrated no improvements between 1990 and 1999 (estimated annual percentage change, 0.1%) and only −1% estimated annual percentage change since 2000. Joinpoint analyses provided consistent results.

Conclusions—
The dramatic decline in CHD mortality since 1979 conceals major heterogeneities. CHD death rates in older groups are now falling steeply. However, young adults have experienced frustratingly small decreases in CHD mortality rates since 1990. The drivers of these major differences in CHD mortality trends by age and sex merit urgent study.
A Spatiotemporal Stochastic Model for Tropical Precipitation and Water Vapor Dynamics
Authors: Hottovy Scott , Stechmann Samuel N. 
Published: August 2015

Abstract
A linear stochastic model is presented for the dynamics of water vapor and tropical convection. Despite its linear formulation, the model reproduces a wide variety of observational statistics from disparate perspectives, including (i) a cloud cluster area distribution with an approximate power law; (ii) a power spectrum of spatiotemporal red noise, as in the “background spectrum” of tropical convection; and (iii) a suite of statistics that resemble the statistical physics concepts of critical phenomena and phase transitions. The physical processes of the model are precipitation, evaporation, and turbulent advection–diffusion of water vapor, and they are represented in idealized form as eddy diffusion, damping, and stochastic forcing. Consequently, the form of the model is a damped version of the two-dimensional stochastic heat equation. Exact analytical solutions are available for many statistics, and numerical realizations can be generated for minimal computational cost and for any desired time step. Given the simple form of the model, the results suggest that tropical convection may behave in a relatively simple, random way. Finally, relationships are also drawn with the Ising model, the Edwards–Wilkinson model, the Gaussian free field, and the Schramm–Loewner evolution and its possible connection with cloud cluster statistics. Potential applications of the model include several situations where realistic cloud fields must be generated for minimal cost, such as cloud parameterizations for climate models or radiative transfer models.
Clouds and Water Vapor in the Tropical Tropopause Transition Layer over Mesoscale Convective Systems
Authors: Virts Katrina S. , Houze Robert A. 
Published: August 2015

Abstract
Observations from A-Train satellites and other datasets show that mesoscale convective systems (MCSs) affect the water vapor and ice content of the tropical tropopause transition layer (TTL). The largest MCSs with radar reflectivity characteristics consistent with the presence of large stratiform and anvil regions have the greatest impact. Most MCSs are associated with clouds in the TTL. Composites in MCS-relative coordinates indicate enhanced cloudiness and ice water content (IWC) extending toward the cold-point tropopause (CPT), particularly in large and connected MCSs. Widespread anvils in the lower TTL are evident in the peak cloudiness diverging outward at those levels. Upper-tropospheric water vapor concentrations are enhanced near MCSs. Close to the centers of MCSs, water vapor is suppressed at TTL base, likely because of the combined effects of reduced moistening or dehydration at the higher TTL relative humidities and subsidence above cloud top. Weak moistening is observed near the CPT, consistent with sublimation of ice crystals at the tops of the deepest MCSs. In the outflow region, moistening is observed in the lower TTL near the largest MCSs. Enhanced water vapor in the upper troposphere and lower TTL extends beyond the area of substantially enhanced cloudiness and IWC, in agreement with the observed radial outflow, indicating that MCSs are injecting water vapor into the environment and consistent with the possibility that MCS development may be favored by a premoistened environment.
Wintertime North Pacific Teleconnection Patterns: Seasonal and Interannual Variability
Authors: Yuan Jiacan , Tan Benkui , Feldstein Steven B. , Lee Sukyoung 
Published: August 2015

Abstract
The teleconnections of the wintertime North Pacific are examined from the continuum perspective with self-organizing map (SOM) analysis. Daily ERA-Interim data for the 1979–2011 period are used. It is found that most of the North Pacific teleconnections can be grouped into several Pacific–North American (PNA)-like, western Pacific (WP)-like, and east Pacific (EP)-like SOM patterns. Each of the SOM patterns has an e-folding time scale of 7–10 days.
The WP-like SOM patterns undergo a decline in their frequency from early to late winter, and vice versa for the EP-like SOM patterns, corresponding to an eastward seasonal shift of the North Pacific teleconnections. This seasonal shift is observed for both phases of the WP and EP patterns, and is only weakly sensitive to the phase of El Niño–Southern Oscillation. It is shown that the interannual variability of the PNA, WP, and EP can be interpreted as arising from interannual changes in the frequency of the corresponding SOM patterns. The WP- and EP-like SOM patterns are found to be associated with statistically significant sea ice cover anomalies over the Sea of Okhotsk and the Bering Sea. The low-level wind and temperature anomalies associated with these patterns are consistent with the changes in sea ice arising from both wind-driven sea ice motion and freezing and/or melting of sea ice due to horizontal temperature advection. Furthermore, widespread precipitation anomalies over the North Pacific are found for all three patterns.
Hydrometeorological Analysis of Tropical Storm Hermine and Central Texas Flash Flooding, September 2010
Authors: Furl Chad , Sharif Hatim O. , El Hassan Almoutaz , Mazari Newfel , Burtch Daniel , Mullendore Gretchen L. 
Published: August 2015

Abstract
Heavy rainfall and flooding associated with Tropical Storm Hermine occurred on 7–8 September 2010 across central Texas, resulting in several flood-related fatalities and extensive property damage. The largest rainfall totals were received near Austin, Texas, and immediately north, with 24-h accumulations at several locations reaching a 500-yr recurrence interval. Among the most heavily impacted drainage basins was the Bull Creek watershed (58 km2) in Austin, where peak flows exceeded 500 m3 s−1. Storm cells were trained over the small watershed for approximately 6 h because of the combination of a quasi-stationary synoptic feature slowing the storm, orographic enhancement from the Balcones Escarpment, and moist air masses from the Gulf of Mexico sustaining the storm. Weather Research and Forecasting Model simulations with and without the Balcones Escarpment terrain indicate that orographic enhancement affected rainfall. The basin received nearly 300 mm of precipitation, with maximum sustained intensities of 50 mm h−1. The Gridded Surface Subsurface Hydrologic Analysis (GSSHA) model was used to simulate streamflow from the event and to analyze the flood hydrology. Model simulations indicate that the spatial organization of the storm during intense rainfall periods coupled with surface conditions and characteristics mediate stream response.
Improve the Simulations of Near-Inertial Internal Waves in the Ocean General Circulation Models
Authors: Jing Zhao , Wu Lixin , Ma Xiaohui 
Published: August 2015

AbstractThe near-inertial wind work and near-inertial internal waves (NIWs) in the ocean have been extensively studied using ocean general circulation models (OGCMs) forced by 6-hourly winds or wind stress obtained from atmospheric reanalysis data. However, the OGCMs interpolate the reanalysis winds or wind stress linearly onto each time step, which partially filters out the wind stress variance in the near-inertial band. In this study, the influence of the linear interpolation on the near-inertial wind work and NIWs is quantified using an eddy-resolving (°) primitive equation ocean model. In addition, a new interpolation method is proposed—the sinc-function interpolation—that overcomes the shortages of the linear interpolation.It is found that the linear interpolation of 6-hourly winds significantly underestimates the near-inertial wind work and NIWs at the midlatitudes. The underestimation of the near-inertial wind work and near-inertial kinetic energy is proportional to the loss of near-inertial wind stress variance due to the linear interpolation. This further weakens the diapycnal mixing in the ocean due to the reduced near-inertial shear variance. Compared to the linear interpolation, the sinc-function interpolation retains all the wind stress variance in the near-inertial band and yields correct magnitudes for the near-inertial wind work and NIWs at the midlatitudes.
Assessing a New Coupled Data Assimilation System Based on the Met Office Coupled Atmosphere–Land–Ocean–Sea Ice Model
Authors: Lea D. J. , Mirouze I. , Martin M. J. , King R. R. , Hines A. , Walters D. , Thurlow M. 
Published: August 2015

Abstract
A new coupled data assimilation (DA) system developed with the aim of improving the initialization of coupled forecasts for various time ranges from short range out to seasonal is introduced. The implementation here is based on a “weakly” coupled data assimilation approach whereby the coupled model is used to provide background information for separate ocean–sea ice and atmosphere–land analyses. The increments generated from these separate analyses are then added back into the coupled model. This is different from the existing Met Office system for initializing coupled forecasts, which uses ocean and atmosphere analyses that have been generated independently using the FOAM ocean data assimilation system and NWP atmosphere assimilation systems, respectively. A set of trials has been run to investigate the impact of the weakly coupled data assimilation on the analysis, and on the coupled forecast skill out to 5–10 days. The analyses and forecasts have been assessed by comparing them to observations and by examining differences in the model fields. Encouragingly for this new system, both ocean and atmospheric assessments show the analyses and coupled forecasts produced using coupled DA to be very similar to those produced using separate ocean–atmosphere data assimilation. This work has the benefit of highlighting some aspects on which to focus to improve the coupled DA results. In particular, improving the modeling and data assimilation of the diurnal SST variation and the river runoff should be examined.
‘Bring Your Own Device’: Considering potential risks to student health
Authors: Merga Margaret K 
Published: August 2015

Background and context: Schools in Australia and internationally are increasingly adopting a Bring Your Own Device (BYOD) approach to teaching and learning. The review: While discussion of a BYOD approach has taken place, there is a dearth of consideration of the potential impact of BYOD policy on student health. Implementation of a BYOD policy may have implications for increased sedentary behaviour, as well as spinal and postural health. Increased use of devices at home to complete homework may also have implications for sleep duration, which in turn may impact upon a range of physical and cognitive issues. BYOD implementation may also increase student vulnerability to cyberbullying. These and other health issues are discussed. Recommendations: Schools may find it helpful to adopt a risk analysis approach informed by social cognitive theory, with an emphasis on the provision of knowledge and the fostering of self-efficacy in order to safeguard against potential health risks. As this issue has significance for researchers in both health promotion and education, an interdisciplinary approach should be taken.
Book Review: Janaki Nair, Mysore Modern: Rethinking the Region under Princely Rule and Aya Ikegame, Princely India Re-imagined: A Historical Anthropology of Mysore from 1799 to the Present
Authors: Zutshi Chitralekha 
Published: August 2015

Janaki Nair, Mysore Modern: Rethinking the Region under Princely Rule, New Delhi: Orient BlackSwan, 2012, pp. 372. Aya Ikegame, Princely India Re-imagined: A Historical Anthropology of Mysore from 1799 to the Present, India: Routledge, 2013, pp. 232.
Clarivein mechanochemical ablation of the great and small saphenous vein: Early treatment outcomes of two hospitals
Authors: Deijen Charlotte L , Schreve Michiel A , Bosma Jan , de Nie A Jorianne , Leijdekkers Vanessa J , van den Akker Peter J , Vahl Anco 
Published: August 2015

Objectives Mechanochemical endovenous ablation is a novel technique for the treatment of great saphenous vein and small saphenous vein incompetence which combines mechanical injury of the endothelium with simultaneous infusion of liquid sclerosant. The main objective of this study was to evaluate early occlusion. Methods All consecutive patients who were eligible for the treatment with mechanochemical endovenous ablation were included. Inclusion period was from the introduction of the device in the hospitals (September 2011 and December 2011) until December 2012. Results A total of 449 patients were included representing 570 incompetent veins. In 506 treated veins, duplex ultrasonography was performed at follow-up: 457 veins (90%) were occluded at a follow-up of 6 to 12 weeks. In univariate and multivariate analysis, failure of treated great saphenous vein was associated with saphenofemoral junction incompetence (OR 4; 95% CI 1.0–17.1, P = 0.049). Conclusions The Clarivein device proves to be safe and had a high short-term technical effectiveness.
Anabolic Steroids Reduce Muscle Degeneration Associated With Rotator Cuff Tendon Release in Sheep
Authors: Gerber Christian , Meyer Dominik C. , Flück Martin , Benn Mario C. , von Rechenberg Brigitte , Wieser Karl 
Published: August 2015

Background: Chronic rotator cuff tendon tearing is associated with irreversible atrophy, fatty infiltration, and interstitial fibrosis of the corresponding muscle. Hypotheses: Anabolic steroids can prevent musculotendinous degeneration during retraction and/or can reverse these changes after operative repair of the retracted musculotendinous unit in sheep. Study Design: Controlled laboratory study. Methods: The infraspinatus tendon was released in 18 alpine sheep. All sheep underwent repair of the retracted musculotendinous unit after 16 weeks and were sacrificed after 22 weeks; 6 sheep served as controls, 6 sheep were treated with weekly intramuscular injection of 150 mg of nandrolone decanoate after infraspinatus (ISP) repair (group N6W), and 6 sheep were treated with 150 mg of nandrolone decanoate immediately after tendon release (group N22W). Muscle biopsy specimens were taken before tendon release and after 16 and 22 weeks. Muscle volume and fatty infiltration (on MRI), myotendinous retraction, and muscle density (on computed tomography) were measured immediately after ISP release, after 6 weeks, and before ISP repair and sacrifice. Results: Muscle volume on MRI decreased to a mean (±SD) of 80% ± 8% of the original volume after 6 weeks, remained stable at 78% ± 11% after 16 weeks, and decreased further to 69% ± 9% after 22 weeks in the control group. These findings were no different from those in group N22W (72% ± 9% at 6 weeks, 73% ± 6% at 16 weeks, and 67% ± 5% at 22 weeks). Conversely, the N6W group did not show a decrease in ISP volume after repair; this finding differed significantly from the response in the control and N22W groups. Fatty infiltration (on MRI) continuously increased in the control group (12% ± 4% at tendon release, 17% ± 4% after 6 weeks, 50% ± 9% after 16 weeks, and 60% ± 8% after 22 weeks) and the N6W group. However, application of anabolic steroids at the time of tendon release (N22W group) significantly reduced fatty infiltration after 16 (16% ± 5%; P < .001) and 22 weeks (22% ± 7%; P < .001). Conclusion: In a sheep model of rotator cuff tendon tear, further muscle atrophy can be prevented with the application of anabolic steroids starting immediately after tendon repair. In addition, fatty muscle infiltration can largely be prevented if the steroids are applied immediately after tendon release. Clinical Relevance: Study findings may lead to the development of treatment strategies to prevent or reduce muscle degeneration caused by rotator cuff tendon tearing.
The influence of ecological and geographical context in the radiation of Neotropical sigmodontine rodents
Authors: Parada Andrés , D’Elía Guillermo , Palma R. Eduardo 
Published: August 2015

AbstractBackgroundMuch debate has focused on how transitions in life history have influenced the proliferation of some clades. Rodents of the subfamily Sigmodontinae (family Cricetidae) comprise one of the most diverse clades of Neotropical mammals (~400 living species in 86 genera). These rodents occupy a wide range of habitats and lifestyles so that ecological context seems relevant to understand the evolution of this group. Several changes in the landscape of South America through the Neogene might have provided vast resources and opportunity to diversify. The aim of this study was to examine whether transitions between i) lowland and montane habitats, ii) open vegetation and forest, and iii) distinct molar architectures are correlated with shifts in diversification rates and to characterize the general pattern of diversification.ResultsBased on a dense taxon sampling of 269 species, we recovered a new phylogeny of Sigmodontinae that is topologically consistent with those of previous studies. It indicates that the subfamily and its major lineages appeared during the Late Miocene. Analyses suggest that vegetation type and elevational range are correlated with diversification rates, but not molar architecture. Tropical lowlands accumulated more lineage diversity than other areas and also supported high speciation rates. Across the radiation the subfamily Sigmodontinae appear to have experienced a decline in diversification rate through time. We detected mixed evidence for lineage-specific diversification rate shifts (e.g., leading to the clades ofAkodon, Bibimys, CalomysandThomasomys).ConclusionWe report that the evolution of habitat preference (considering vegetation type and elevational range) was associated with diversification rates among sigmodontine rodents. We propose that the observed diversification slowdown might be the result of ecological or geographical constraints. Our results also highlight the influence of the tropical lowlands -which might have acted as both “a cradle and a museum of species.” The tropical lowlands accumulated greater diversity than the remainder of the group's range.
High quality draft genomic sequence of Arenimonas donghaensis DSM 18148T
Authors: Chen Fang , Wang Hui , Cao Yajing , Li Xiangyang , Wang Gejiao 
Published: August 2015

AbstractArenimonas donghaensis is the type species of genus Arenimonas which belongs to family Xanthomonadaceae within Gammaproteobacteria. In this study, a total of five type strains of Arenimonas were sequenced. The draft genomic information of A. donghaensis DSM 18148T is described and compared with other four genomes of Arenimonas. The genome size of A. donghaensis DSM 18148T is 2,977,056 bp distributed in 51 contigs, containing 2685 protein-coding genes and 49 RNA genes.