bluuebunny/crossref_metadata_2025_split huggingface dataset:
Black radish root extract alleviates sodium valproate-induced liver damage via inhibiting mitochondrial membrane potential collapse and oxidative stress in mice
Authors: Zarei Mohammad Hadi , Akbulut Sami , Zafari Maryam , Saghaei Elham , Lorigooini Zahra , Khoei Hossein Amini , Khosravi Somaye , Bijad Elham 
Published: July 2024

Objective:
To explore the effect of black radish (Raphanus sativus L. var niger) root extract on liver enzymes, oxidative stress, and histopathological alterations in mice with sodium valproate-induced hepatotoxicity.

Methods:
Thirty-two mice were divided into four groups: the control group received drinking water by gavage, the second group was administered with 100 mg/kg of sodium valproate, the third group received 300 mg/kg of black radish root extract, and the fourth group was given both sodium valproate (100 mg/kg) and black radish root extract (300 mg/kg). After 28 days, the mice were euthanized, and serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP), along with liver malondialdehyde (MDA), reactive oxygen species (ROS), mitochondrial parameters, tumor necrosis factor-alpha (TNF-α) gene expression, and histopathological changes were assessed.

Results:
Sodium valproate caused hepatic damage in mice, characterized by elevated serum levels of liver enzymes, increased MDA and ROS levels and TNF-α gene expression, as well as histopathological alterations. The black radish root extract significantly alleviated sodium valproate-caused hepatic injury by decreasing the serum levels of ALT and AST, MDA, ROS, TNF-α gene expression, as well as mitochondrial impairment, but did not have a significant effect on sodium valproate-induced histopathological changes.

Conclusions:
The black radish root extract demonstrates protective effects against sodium valproate-induced liver injury, possibly through mitigating oxidative stress, mitochondrial impairment, and inflammatory mediator expression.
Association of methylenetetrahydrofolate reductase A1298C mutation with normal homocysteine level: A rare cause of cerebral venous sinus thrombosis in an infant
Authors: Sahoo Bandya , Das Palash , Mishra Reshmi 
Published: July 2024

Abstract
Inherited causes of cavernous venous sinus thrombosis (CVST) leading to stroke in infancy are rare. Methylenetetrahydrofolate reductase (MTHFR) gene mutation is one such cause. Polymorphism of MTHFR, an essential enzyme in Vitamin B12 metabolism, leads to an increase in homocysteine levels. This is a prothrombotic state and, therefore, causes pediatric stroke. Children with a mutation of the MTHFR gene have elevated homocysteine levels. The index case of MTHFR polymorphism with CVST leading to stoke had a normal homocysteine level. The association of MTHFR A1298C mutation with CVST can be confirmed only after further studies, as the role of heterozygous A1298C mutation in prothrombotic state is conflicting.
Improvement in Glycemic Indices and Point in Range by Addition or Switch to IDegAsp–Real-World Evidence
Authors: Seshadri Krishna G. , Polisetti Subhadra , Tippisetty Surekha 
Published: July 2024

Abstract

Aim and Objectives:
This study aimed to evaluate the effectiveness of insulin degludec/insulin aspart (IDegAsp) in uncontrolled type 2 diabetes mellitus (T2DM) patients in clinical practice settings.

Materials and Methods:
This study includes a retrospective analysis of uncontrolled T2DM patients on oral antidiabetic drugs and/or insulin (basal, bolus, or premix) and initiated on IDegAsp and in a subgroup of patients who switched from insulin glargine to IDegAsp. Clinical endpoints were mean change in glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and % point in range (PIR) before and after treatment with IDegAsp. Descriptive statistics were applied to analyze the data, and statistical significance was set at P ≤ 0.05.

Results:
A total of 540 patients with T2DM were initiated on IDegAsp, among which 85 switched from insulin glargine (U100/300) to IDegAsp. In 6 months, overall, the mean change in glycemic variables HbA1c, FPG, and PPG was –0.3%, –21 mg/dL, and –36 mg/dL, and among those who switched from insulin glargine to IDegAsp, it was –0.4%, –18 mg/dL, and –49 mg/dL, respectively, and the difference was statistically significant (P < 0.05). Self-monitored blood glucose, 1 month before and from 4 to 6 months after initiation of IDegAsp was assessed in overall 43 patients. The % PIR before breakfast and before dinner (BBF+BD) was 68% and 69% (95% CI –4.413 to 4.902) respectively. Furthermore, among those who switched from insulin glargine to IDegAsp (n = 25), BBF + BD increased from 67% to 77% (95% CI –10.35 to 10.65).

Conclusion:
Our results show clinically significant improvements in glycemic variables and PIR in patients treated with IDegAsp and especially in patients who switched from insulin glargine (U100/300) to IDegAsp.
Extensive Fournier’s Gangrene Due to Delayed Management of Perianal Abscess in Uncontrolled Diabetes: A Case Report
Authors: Pandiaraja Jayabal , Shalini Arumugam 
Published: July 2024

Abstract
Fournier’s gangrene is a rapidly spreading gangrene predominantly affecting the genital and perianal region. It has the highest mortality and is more common in immunocompromised and diabetic patients. Poorly controlled diabetes is one of the common risk factors for Fournier’s gangrene. Delayed diagnosis and treatment increase mortality by nearly 100%. In our case, the patient was initially managed for a perianal abscess and later progressed to Fournier’s gangrene. A 48-year-old male diabetic presented with erythematous swelling in the right-side scrotal region for one-week duration. He had a recent perianal abscess and underwent incision and drainage at another hospital He also reported fever with chills and rigors for the past two days. The patient is now in a state of septic shock. He has a history of irregular medication for type 2 diabetes mellitus. Clinical examination confirmed Fournier’s gangrene resulting from a perianal abscess in the context of uncontrolled diabetes. The patient underwent an emergency wound debridement under spinal anesthesia. Extensive wound debridement was performed on the right hemiscrotum. Necrotic tissue was debrided on the right perianal region. The patient was initiated on empirical antibiotics, receiving a calculated dose of cefoperazone with sulbactam and metronidazole. Additionally, the patient underwent sitz baths and received regular wound dressing. Following wound debridement and glycemic control with insulin, the patient showed signs of improvement. Four weeks post-debridement, the patient underwent split-skin grafting for the raw area on the scrotum, while the fistula site was allowed to heal by secondary intention. The cornerstone in managing perianal abscess with Fournier’s gangrene in diabetic patients is extensive wound debridement, antibiotic coverage, and proper management of diabetes. Early diagnosis and prompt surgery of perianal abscess can reduce the risk of developing Fournier’s gangrene in diabetic patients. Post-surgical raw areas can be effectively managed with split-skin grafts.
Pediatric Type 1 Diabetes: A Bibliometric Analysis of the 100 Most-cited Publications
Authors: Dayal Devi , Gupta Brij Mohan , Mamdapur Ghouse Modin , Vaishya Raju , Gupta Atul , Bansal Madhu 
Published: July 2024

Abstract

Background:
The most impactful research on pediatric type 1 diabetes (T1D) remains unknown.

Objective:
We aimed to evaluate the characteristics and impact of the 100 most-cited articles on pediatric T1D.

Materials and Methods:
Using a predefined bibliometric strategy, the Scopus database was searched for high-cited papers (HCPs) published from 2001 to 2020. Articles were evaluated for data on the publication year, countries, authors, journals, topics, and types. Social network analysis was performed to visualize the interaction among countries, organizations, and authors using VOSviewer software.

Results:
The top 100 HCPs received 390 to 4634 citations, averaging 773.5 citations per paper (CPP). The funded HCPs (n = 50) had a higher impact (CPP 791.5). The majority of HCPs (n = 83) were collaborative. Classifying by research type, 65 studies were clinical (n = 65), risk factors (n = 27), epidemiology (n = 26), pathophysiology (n = 16), treatment outcome (n = 13), genetics (n = 12), complications (n = 3), quality of life (n = 2), and prognosis (n = 1). The number of authors involved was 1,101, affiliated with 545 organizations in 27 countries; the USA (n = 64) and the UK (n = 24) were the most productive countries, whereas Australia and the UK were the most impactful. D.M. Nathan and J.M. Lawrence were the most prolific authors, while P. Raskin and J.M. Lachin were the most impactful.

Conclusions:
High-income countries such as the USA, UK, and Australia contribute significantly to high-impact pediatric T1D research. Funding and collaboration improve the impact of citations in publications. Less researched areas such as treatment outcomes, genetics, complications, quality of life, and prognosis should be the focus of future research on pediatric T1D.
Correlation between handgrip strength and lower extremity strength amongst Malaysian professional football players
Authors: Naim Ezzat , Hamid Mohamad Shariff A. 
Published: July 2024

ABSTRACT

Background:
We investigated the pattern of handgrip strength (HGS) and lower extremity strength in professional football players and how they were correlated.

Methods:
Secondary data were gathered during pre-participation evaluation sessions from a sample of 87 Selangor state-based Malaysian professional football players. The statistical analysis of the pattern of lower limb strength and HGS was based on the player’s position on the field. The correlation between HGS and lower extremity strength was looked at using Pearson’s correlation coefficient. The factors that affect HGS were analysed using a multivariate regression model.

Results:
In both dominant (P = 0.026) and non-dominant hands (P = 0.016), goalkeepers had significantly higher HGS than strikers. Dominant HGS had a moderate correlation with knee extensor strength (r = 0.38, P < 0.05). The moderate correlation between HGS and knee extensor strength remains consistent despite being controlled for weight (r = 0.33, P <0.05) and skeletal muscle mass (SMM) (r = 0.31, P < 0.05). Significant correlations were observed despite the lower correlation value between dominant HGS and hip flexor strength (r = 0.31, P < 0.05), hip extensor strength (r = 0.30, P < 0.05) and knee flexor strength (r = 0.29, P < 0.05). Dominant knee extensor strength and SMM were identified as statistically significant predictors for dominant HGS (F [2,84] = 11.60, P < 0.01) with R2 = 0.22.

Conclusions:
The unique anthropometric traits of professional footballers, especially goalkeepers, improve HGS. Handgrip and knee extensor strength were moderately correlated, supporting previous study findings on the existence of a non-local effect between upper limb and lower limb strength.
Apple Vision Pro’s new technology as a head-mounted perimetry device for glaucoma and other potential applications
Authors: Masalkhi Mouayad , Ong Joshua , Waisberg Ethan , Dervan Edward , Lee Andrew G. 
Published: July 2024

Abstract
Glaucoma is a leading cause of irreversible blindness worldwide and poses a significant public health challenge. Primary open-angle glaucoma (POAG) is the most common form of glaucoma and is marked by progressive optic nerve damage and peripheral visual field loss. Early detection and management of glaucoma are essential to prevent severe vision impairment. Perimetry measures visual field sensitivity and is a crucial tool for diagnosing and the progression of glaucoma. However, traditional perimetry devices are bulky, expensive, and require specialized settings, thereby limiting their accessibility. Studies indicate the evolving role of portable and home-based visual field testing, where the efficacy of virtual reality (VR) devices such as the VisuALL against traditional perimetry tools. Apple Vision Pro’s integration into glaucoma management could address the limitations of conventional perimetry, and thus making monitoring more feasible and less burdensome. In this manuscript, we explore the potential of Apple Vision Pro’s technology as a head-mounted perimetry device for glaucoma. The Apple Vision Pro headset leverages advances in augmented reality and wearable computing to offer a portable, cost-effective solution for visual field testing. Its compact design enables patients to perform tests at home, thus reducing the need for clinical visits and improving adherence to monitoring protocols. This portability is also particularly beneficial in space environments, such as on the International Space Station, where regular monitoring of visual health of astronauts is critical.
Torpedo maculopathy
Authors: Shrinkhal  
Published: July 2024

Abstract
Torpedo maculopathy is a rare congenital defect of the retinal pigment epithelium that produces a disruption of outer retinal layers. It is a hypopigmented torpedo-shaped lesion temporal to the macula, pointing toward the fovea. The visual acuity is usually normal because there is no foveal involvement. Regular follow-up is required in these patients as they can develop choroidal neovascularization.
Case of neonatal diabetes mellitus due to KCNJ11 mutation: Therapeutic implications of a genetic diagnosis
Authors: Marakkar Shagufa , Soodhana Dhanya , Apala Shinju , Gangan Roshni , Anirudhan Vinitha K. , Anand Manjula 
Published: July 2024

Abstract

BACKGROUND:
Neonatal diabetes mellitus (NDM) is a rare condition occurring in approximately 1 in 90,000 live births.

CASE REPORT:
We describe a 2.5-month-old infant with neonatal diabetes who presented with diabetic ketoacidosis due to a mutation affecting the KCNJ11 gene, which encodes the Kir6.2 subunit of the ATP-sensitive potassium channel in pancreatic beta cells.

CONCLUSION:
Availing a genetic diagnosis has crucial therapeutic implications in the initiation of oral sulfonylureas in KCNJ11 and ABCC8 mutations as against the continued use of subcutaneous insulin in some other causes of neonatal diabetes.
Navigating the chemotherapy-induced acute motor and sensory axonal neuropathy and diabetic ketoacidosis in an adolescent girl with acute lymphoblastic leukemia: A case report
Authors: Kuriakose Mathews E. , Francis Johny Vakayil , Chandrababu Aruna , Rajan Varun 
Published: July 2024

Abstract
Acute lymphoblastic leukemia (ALL), the most common hematological malignancy of childhood, can cause significant morbidity and mortality due to the tumor burden or toxic effects of chemotherapeutic agents. Early detection and appropriate treatment of these complications are crucial for improving survival and quality of life. We report a case of a 12-year-old girl with B-cell ALL who experienced multiple chemotherapy-related adverse events, namely pancreatitis, hypertriglyceridemia, and a rare combination of steroid and l-asparaginase-induced hyperglycemia with diabetic ketoacidosis, and vincristine-induced acute motor and sensory axonal neuropathy. She was managed by discontinuation of vincristine and l-asparaginase and given intravenous immunoglobulin, fluid resuscitation, and antibiotics. She had a full neurological recovery within 2 months and continued with the modified chemotherapy protocol.
Direct Evidentials in Korean: From the Perspective of the Multi-Store Memory Model
Authors: Moon Chang-Hak 
Published: July 2024

This study clarifies the meaning of direct evidential markers in Korean and examines their semantic characteristics using a multi-store memory model. Korean direct evidential markers are categorized into those indicating either “present perception-based knowledge” or “past acquisition-based knowledge.” The former are subdivided into “unaccepted present perception-based knowledge” (-네 -ney) and “accepted present perception-based knowledge” (-군 -kwun), and the latter into “knowledge derived from past perception” (-더라 -tela) and “knowledge integrated into personal or general understanding” (-지 -ci). Within the multi-store memory model, -네 -ney aligns with the indicator of the maintenance rehearsal process, while -군 -kwun serves as an indicator of elaborative rehearsal, and -더라 -tela and -지 -ci correspond to retrieval indicators from long-term memory.
Lifelong Learning among Students in the Context of COVID-19: A Case Study of the SADC Region
Authors: Chauke Thulani Andrew 
Published: July 2024

COVID-19 has disrupted the process of teaching and learning across the globe, posing significant challenges to educational institutions worldwide. Some universities in the Southern African Development Community (SADC) region faced difficulties in transitioning to online learning, which adversely affected students' academic progress. The pandemic intensified the existing inequalities in the SADC region, further marginalising students from disadvantaged backgrounds and impeding their access to quality education. However, despite the adverse effects of COVID-19 on traditional contact-based learning, students managed to acquire a new set of skills necessary for navigating the digital age. Moreover, the pandemic presented opportunities for students in the SADC region to develop essential skills for participation in the mainstream economy. This study examines how COVID-19 disrupted students' academic development, and the lessons that students learnt during the pandemic in the SADC countries, with a special focus on South Africa and Zimbabwe. The study concludes by highlighting the interventions adopted by higher education institutions in the SADC region to support students in the context of COVID-19. Methodologically, this study employed secondary data analysis, including policies and existing literature. The findings reveal that students learnt new and innovative ways of studying during the pandemic. This study is underpinned by the self-directed learning theory, which emphasises the importance of self-reliance among students. An important recommendation concerns implementing policies within SADC to promote lifelong learning among students, both during and after COVID-19. In addition, the study proposes that higher education institutions establish tech-innovation hubs on campuses, where students can interact and acquire new skills needed in the digital age.
Efektivitas Senam Lansia Terhadap Perubahan Depresi dan Kualitas Hidup Lansia
Authors: Ngadiran Antonius , Eny Pujiati  
Published: July 2024

Depresi yang terjadi usia lanjut berkisar 1-2%, kejadian pada wanita 1.4% dan pada laki-laki 0.4%. Depresi pada lansia membutuhkan upaya pencegahan menggunakan aktivitas fisik, salah satu aktivitas fisik dengan olahraga lansia. Penelitian ini bertujuan untuk membuktikan apakah ada pengaruh olahraga lansia terhadap perubahan tingkat depresi dan kualitas hidup lansia. Desain penelitian yang di gunakan menggunakan kuasi eksperimen dengan menggunakan pendekatan sebelum dan sesudah test dilakukan pada 73 lanjut usia yang dikelompokkan menjadi dua, yaitu 36 lansia pada kelompok perlakuan dan 37 lansia pada kelompok pembanding. Analisa data berpedoman pada proposal penelitian, data yang terkumpul dianalisa menggunakan tingkat signifikansi < 0,05. Responden mengikuti latihan 3x/minggu selama 12 minggu. Setelah mengikuti senam lansia skor depresi mengalami penurunan secara signifikan di bandingkan kelompok pembanding dengan nilai p value 0,000. Setelah mengikuti senam lansia skor kualitas hidup mengalami peningkatan secara signifikan di bandingkan kelompok pembanding dengan nilai p value 0,010. Lansia yang melakukan latihan berbasis motorik (senam lansia) secara teratur, dengan durasi 30 menit tiap latihan, dengan frekuensi 3x tiap minggu selama 12 minggu mempunyai kualitas hidup yang lebih baik jika dibandingkan dengan lanjut usia yang melakukan aktifitas lain.
THE HUMAN ASPECT OF ICT IMPLEMENTATION IN THE JAPANESE EDUCATION SYSTEM: A CASE STUDY OF PRE-PANDEMIC SECONDARY EDUCATION IN KANAGAWA PREFECTURE
Authors: Woo Soonbo (Nicholas) 
Published: July 2024

This article is based on a case study done at one public secondary school in Yokohama, Japan with supplementing data from surrounding schools. The aim of the research is to bring attention to student and teacher lifestyles concerning information communication technology (ICT) prior to the pandemic (before it became an enforced necessity) in personal and school-related settings and discuss possible implications for ICT policies at secondary schools in Japan. After a yearlong observation period, a questionnaire was conducted to find specific patterns that could impact ICT policies for the school. Additionally, teachers and parents were interviewed for details and information to highlight potential reasons behind the survey results along with additional findings. Interviews from surrounding schools were conducted to further supplement the case study. The analysis focused on finding patterns that highlight positive and negative elements of ICT perceived by the students, teachers, and parents at the school. Discovered patterns were further discussed to find implications for policy development and areas for future research. Critical findings included the deterring factors for teachers to use ICT being nearly identical to the desired factors for parents, thus creating a conflict of interest when it comes to ICT use cases for school-related purposes. Additional findings include the parents’ roles in assisting ICT-related productivity work in conjunction with modern-day smartphone consumerism, which leads to a lack of productivity mindset for the students. It was identified that without measures in place to address teachers, it is difficult to expand the usage of ICT for teachers with just a general policy and device availability. This implies that post-pandemic ICT plans could still produce resistance and issues from users despite their proliferation and that any progress in ICT for education can enter stagnation unless the issues found in this study are addressed.<p> </p><p><strong> Article visualizations:</strong></p><p><img src="/-counters-/soc/0102/a.php" alt="Hit counter" /></p>