bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single Flap Approach Versus Conventional Flap in the Treatment of Intrabony Defects: A 6-Month Clinico Radiological Study
Authors: Nayak Prahi , Shetty Neema , Manohar Balaji , Mathur Aditi , Makhijani Barkha , Chakraborty Richik 
Published: August 2024

Introduction:
The comparison of single-flap approach (SFA) and conventional flap (CF) techniques in the treatment of intrabony defects is a significant area of periodontal research. This clinical-radiological study evaluates the effectiveness of these methods over a 6-month period. SFA involves minimal surgical intervention, promoting faster healing and reduced patient discomfort. Conversely, CF is a traditional method with broader exposure to the surgical site for more extensive cleaning and repair. This study aims to provide insights into the relative advantages and clinical outcomes associated with each approach, contributing to evidence-based periodontal therapy practices.

Materials and Methods:
Thirty sites with chronic/aggressive periodontitis were selected for the present study. Phase I therapy was performed and evaluated after 4 weeks. Clinical parameters such as plaque and gingival index and probing pocket depth (PPD) were measured at baseline and 6 months postoperatively. The mean defect fills and percentage defect fill were calculated with the help of cone-beam computed tomography at baseline and 6 months postoperatively. The subjects were divided into two equal groups with the help of a coin toss. The Group I (test sites) underwent an SFA, whereas the Group II (control) site underwent conventional surgical procedures.

Results:
The PPD in both groups was reduced over a 6-month post-operative period. The mean defect size and percentage of defect fill between baseline and 6 months postoperatively in both groups were statistically significant.

Conclusion:
The single-flap approach and the CF are equally effective in treating periodontal intrabony defects.
Diagnostic Challenges in Depression – A Rare Case of Depression Associated with Pachymeningitis
Authors: Das Koushik , Ray Sagarika 
Published: August 2024

Abstract
Hypertrophic pachymeningitis is a rare neurological disorder, with nonspecific initial symptoms, which lead to difficulty in early diagnosis. Psychiatric manifestations have rarely been reported in association with this disorder. In this article, we report the case of a female patient, who was initially diagnosed as suffering from depressive disorder but was later diagnosed as suffering from underlying hypertrophic pachymeningitis. The bidirectional nature of depression with inflammation can also be ascertained from the course of the disease and the treatment offered. The initial presenting depressive symptoms, somatic complaints, headache, and ocular symptoms had responded well to paroxetine, until there was an episode of lower respiratory tract infection, following which all her symptoms aggravated. Detailed neurological work-up confirmed the diagnosis of pachymeningitis. Immunosuppressant therapy was employed using steroids, while continuing paroxetine, which led to near-complete recovery of both her ocular and depressive symptoms.
Safety of low-intensity extracorporeal shock wave therapy in prostate disorders: in vitro and in vivo evidence
Authors: Wang Yi-Ran , Feng Bin , Qi Wen-Bo , Gong Yu-Wen , Kong Xiang-Bin , Cheng Hui , Dong Zhi-Long , Tian Jun-Qiang , Wang Zhi-Ping 
Published: August 2024

Abstract
Recent evidence suggests that low-intensity extracorporeal shock wave therapy (Li-ESWT) is a promising treatment for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS); however, its safety in pelvic organs, particularly prostate tissues and cells, remains unclear. The current study evaluates the risks of prostate cell damage or oncogenesis following the administration of Li-ESWT for prostatitis. To this end, a robust in vitro model (Cell Counting Kit-8 [CCK-8] assay, clone formation assay, cell scratch assay, lactate dehydrogenase [LDH] release assay, flow cytometry, and immunoblotting assay) was designed to examine the effects of Li-ESWT on cell proliferation, clonogenicity, migration, membrane integrity, and DNA damage. Exome sequencing of Li-ESWT-treated cells was performed to determine the risk of carcinogenesis. Furthermore, an in vivo rat model (n = 20) was employed to assess the effects of Li-ESWT on cancer biomarkers (carcinoembryonic antigen [CEA], Ki67, proliferating cell nuclear antigen [PCNA], and gamma-H2A histone family member X, phosphorylation of the H2AX Ser-139 [γ-H2AX]) in prostate tissue. Based on our findings, Li-ESWT promotes cellular growth and motility without inducing significant cell membrane or DNA damage or alterations. Genetic analyses did not demonstrate an increase in mutations, and no damage to prostate tissue or upregulation of cancer biomarkers was detected in vivo. This comprehensive in vitro and in vivo assessment confirms the safety of Li-ESWT in managing prostate disorders.
Management of Functional Status of a Floppy Child with Ayurveda and Panchakarma: A Case Report
Authors: Pandey Vidya Bhushan , Kumar Abhimanyu , Pandey Shweta , Rathi Renu Bharat 
Published: August 2024

ABSTRACT
The floppy (hypotonic) condition often presents with abnormally lower muscle tone, resulting in the limpness of the body. Antigravity muscle movements are difficult to perform. This case had a brain lesion due to hypoxic–ischemic encephalopathy inside the cerebrum. Hypotonic cases in Ayurveda are close to Vata Vayadhi (~Diseases due to Vata dosha alleviation) with Avarana (~occlusion) due to Shiromarmaghata (~damage to the brain). This state is with symptoms such as Chestanasha (~loss of movement), Gatra vikshep sanga (~restricted body movements), and Sarveshu Skhalitam Cha Gatau Bhrusham (~fall during the walk) close to hypotonic status. In this article, a 2 and a ½-year-old male child with diagnosed hypotonic status and delayed milestones attended Kaumarbhritya outpatient department. He was not able to balance or stand with support and would lie down while sitting. He was managed according to Ayurveda guidelines for 180 days. The case was provided oral Ayurveda medications, Panchakarma therapy, and some basic exercises. The case was assessed after 60 days for the outcome of the treatment. After 180 days, a multifaceted improvement is seen. The patient started standing and walking without support, and his power grade of muscle and joints also improved. His advanced daily living activities that scored 10, before treatment improved to 70, after treatment (AT). With all-around improvement, his Gross Motor Functional Classification System score also improved from 3 to 1, AT. Magnetic resonance imaging changes were seen after a period of treatment, showing gliotic changes AT reflecting healing and neuroplastic changes. Conclusively, early intervention with Ayurveda can change the functional status in hypotonic conditions.
Pharmacognosy and Analytical Profile of Bhunimbadi Churna: A Polyherbal Formulation
Authors: Sharma Pratik , More Anand B. , Galib R , Rai Shalini , Upadhyay Anjali 
Published: August 2024

ABSTRACT

Background:

Charak Samhita, an ancient Ayurvedic text, offers a vast repository of effective polyherbal formulations for treating various diseases. Ensuring the standardization and authentication of these compound formulations is crucial for quality control and enhancing their therapeutic efficacy. Establishing reliable data to set standard parameters is essential for verifying the genuineness of individual formulations and drugs as a whole.

Aims and Objectives:
The primary aim of this study is to evaluate and assess Bhunimbadi Churna, a classical formulation mentioned in the Grahanidosha Chikitsa Adhyaya of Charak Samhita, known for its multiple therapeutic indications. The objectives include conducting a comprehensive pharmacognostical and pharmacological assessment of the formulation to establish standard parameters for quality control.

Materials and Methods:
The study involved a detailed examination of Bhunimbadi Churna using standard scientific protocols. The assessment included organoleptic characteristics, physico chemical parameters, physical characteristics of the powder (Churna), preliminary phytochemical analysis, and high performance thin layer chromatography (HPTLC) analysis.

Results:
On performing the experiments for three consecutive readings, loss on drying was found to be 7.66 ± 0.21, pH was 5.53 ± 0.19, total ash value of powder was found to be 6.64 ± 0.20 w/w, and acid insoluble ash was found to be 0.52 ± 0.11 w/w. These parameters provide a reliable framework for assessing the quality and authenticity of the formulation.

Conclusion:
The findings of this study offer valuable tools for regulatory authorities, scientific organizations, and manufacturers to develop standardized formulations of Bhunimbadi Churna. The reproducible parameters established in this study can assist in ensuring the quality and efficacy of this classical Ayurvedic formulation.
Measuring the Manasika Prakrti of the Children by the Parent Rating Scale
Authors: Suchitra S. P. , Nagendra H. R. 
Published: August 2024

ABSTRACT

Background:
Inventories to asses guna personality have been developed and validated for adults. However, are not based on Ayurveda concepts. The objective of the study was to develop and standardize an inventory to assess the Manasika prakrti of the children according to Ayurveda.

Methods:
The 70-item Ayurveda guna inventory for children (AGIC) was developed on the basis of the translation of Sanskrit verses describing Sattva (A), Rajas (B), and Tamas prakrti (C) characteristics and by taking the opinions of experts (ten Ayurveda experts and three psychologists). The scale was tested out in Maxwell Public School, Bangalore. The scale was administered on parents of children of the age group 6–12 years.

Results:
The AGIC was associated with excellent internal consistency. The Cronbach’s alpha for the A-, B-, and C-scales was 0.80, 0.55, and 0.56, respectively. Moreover, the split-half reliability was 0.79, 0.56, and 0.64, respectively. Factor validity coefficient scores on each item were above 0.5 on the Sattva, Rajas, and Tamas scale.

Conclusions:
The Manasika prakrti (trigunas) of the children can be measured reliably by this instrument.
Flu-like symptoms following botulinum toxin A application before incisional hernia repair: A case report
Authors: Kulacoglu Hakan , Alptekin Alp , Celasin Haydar 
Published: August 2024

Abstract
Botulinum toxin has been used for the treatment of numerous medical conditions. Recently, preoperative botulinum toxin A (BTA) injections into the lateral abdominal wall muscles are beneficial for facilitating ventral hernia repairs and improving surgical outcomes. Early and late, local and systemic adverse effects of BTA application have been described, some of them are flu-like symptoms (FLS). However, no case of FLS following botulinum toxin injections before ventral hernia repair has been described. In this report, we present a 58-year-old female patient who developed FLS episodes throughout preoperative and postoperative periods following BTA injections.
Nursing Care Challenges for Patients Suffering from COVID-19 from Nurses' Perspective in Iran: A Descriptive Qualitative Study
Authors: Atashi Vajiheh , Safazadeh Shima , Taleghani Fariba , Sami Ramin , Ahmadi Shokoufeh , Pourkermanian Pourandokht 
Published: August 2024

Background:
Encountering the coronavirus disease 2019 (COVID-19) pandemic, nurses face many challenges due to various strategies and resources that can compromise the quality of care. This study aimed to identify nursing care challenges for patients with COVID-19 from nurses' viewpoint in Iran.

Materials and Methods:
This descriptive qualitative study was conducted in one of the main admission centers in Isfahan to treat patients with COVID-19. Data were collected through semi-structured in-depth interviews with 19 nurses from April 2020 to June 2020. The recorded interviews were transcribed and then analyzed through inductive content analysis.

Results:
The challenges of nursing care for patients infected with COVID-19 from the nurses' viewpoint were categorized into 11 subcategories and four main categories: work overload in disaster (lack of nurses with adequate clinical qualification and restrictions on the compliance of the infection control protocols), immersion in an ocean of psychological and social tensions (personal and family tensions, work environment tensions, perception of organizational injustice, and social stigma), quality of care in fragile condition (self-preservation rather than patient care and contradictory patient care standards), and disaster preparedness, response, and management (passive resource management, information system challenges, and lack of guideline-supported protocols).

Conclusions:
The findings of this study suggest that policymakers should actively participate in supporting nurses in the form of reducing physical and mental stress in pandemics such as COVID-19. Having the right perception of the challenges nurses face in such crises can contribute to providing patient safety, improving the quality of care, maintaining organizational resources, and properly managing the disaster.
Structural Model of Family Caregiver for Elderly with Dementia
Authors: Sya'diyah Hidayatus , Nursalam Nursalam , Mahmudah Mahmudah , Efendy Ferry 
Published: August 2024

Background:
The number of older people with dementia was continuously increasing globally. Unfortunately, many of them had received inappropriate medical treatment to overcome the dementia they suffered. This current research aimed to analyze the factors that affected family-based caregiver empowerment.

Materials and Methods:
An analytic observational method with a cross-sectional approach was applied. The population was all families with dementia elderly in East Java, Indonesia, in 2021, who met the inclusion and exclusion criteria. The sample size was determined to be 100 respondents.

Results:
The results showed that the factors (i.e., elderly factors, family factors, health service factors, family's filial value, family assessment, and the need for care) had significant effects directly or indirectly on the family's ability to do home care.

Conclusions:
Factors that influenced directly (i.e., elderly factors, family factors, family assessment, and care needs) and indirectly (i.e., health service factors) were essential in constructing a structural model of family care for the elderly with dementia.
Comparing the Effect of Premature Infant Care Training and Performing Auriculotherapy Techniques on Anxiety, General Self-Efficacy and Breastfeeding Self-Efficacy of Mothers with Premature Infants
Authors: Rabiee Niloofar , Ghasempour Zahra , Abolhassani Moussa , Haghighi Nahid Bolbol 
Published: August 2024

Background:
A preterm birth exposes the mother to many challenges in caring for and supporting the baby. This study aims to use training and auriculotherapy techniques as two simple methods to reduce anxiety and increase the mother's self-efficacy.

Materials and Methods:
This single-blind three-group clinical trial study was conducted in the Bahar Hospital in Shahroud, Iran, in 2019. The target group of primiparous mothers was premature infants. For the first group, premature infant care training was provided, and for the second group, auriculotherapy techniques were performed, and the third group (the control group) received routine care. Anxiety, general self-efficacy, and maternal breastfeeding self-efficacy were measured at the beginning of the study and before neonatal discharge.

Results:
Before the intervention, three groups were not significantly different in demographic characteristics, obvious and hidden anxiety scores, and general self-efficacy and lactation (p > 0.05). There was a significant difference between the control group and the two intervention groups with ANOVA test for self-efficacy (F2,87 = 6.60, p = 0.002), breastfeeding self-efficacy (F2,87 = 15.20, p < 0.001), obvious anxiety (F2,87 = 56.20, p < 0.001), hidden anxiety (F2.87 = 62.90, p < 0.001), after the intervention. In addition, there was no significant difference in the length of hospital stay in the neonatal intensive care unit (p = 0.732). Still, the neonate's infant's mean weight before discharge in the two intervention groups was significantly different from the control group (p = 0.034).

Conclusions:
Teaching mothers how to care for premature infants and implement auriculotherapy techniques reduces anxiety and increases mothers' general self-efficacy and breastfeeding.
Informal Caregivers and Care Burden in Iran: Systematic Review and Meta-Analysis
Authors: Amiresmaili Mohammadreza , Goudarzi Reza , Agoush Leila 
Published: August 2024

Background:
The increase in the average age of the population, the decrease in the size of the household and rising in the number of working women impose an increasing burden on home caregivers in Iran. The aim of this study was to measure care burden of informal caregivers in Iran through systematic review and meta-analysis of existing literature.

Materials and Methods:
A systematic review was conducted by using national and international databases of Scopus, PubMed, Embase, Web of Science, SID, Magiran, and IranDoc papers in English and Persian language up to the first half of 2020. In this meta-analysis, we calculated the pooled care burden and 95% confidence intervals in Statistical Software For Data Science (STATA) V.15.

Results:
Forty-four papers were included in the current study based on inclusion and exclusion criteria comprising of 8626 samples. Pooled mean of Burden of Care was 52.01 (95% CI: 48.21-55.82). Highest pooled mean(SD) of care burden (64.37) was related to caregivers of schizophrenia patients (95% CI: 56.09–72.64). Highest care burden (53.45) was observed in most deprived areas (95%CI = 47.05–59.86). A statistically significant relationship was observed between caregivers gender and care burden (p < 0.05).

Conclusions:
The reported care burden of informal caregivers requires the establishment of a support system to control mental and physical stress. Due to the dispersion and cultural diversity in Iran, more studies are needed to obtain more accurate data.
Knowledge, Attitudes, and Anxiety of Midwives Toward Maternal Care During the COVID-19 Pandemic: A Descriptive Study on Midwives Who Experience the Perinatal and Breastfeeding Phases
Authors: Ocktariyana  , Lestari Dian 
Published: August 2024

Background:
People all over the world, including pregnant women, have experienced stress and anxiety due to the coronavirus disease 2019 (COVID-19) pandemic. Providing services during the pandemic is something that midwives in primary health care cannot avoid. This study assesses a midwife's knowledge, attitude, and anxiety toward providing maternal care during the pandemic.

Material and Method:
A cross-sectional design was used in this study, which involved 183 midwives who provided midwifery services at hospitals and health centers and had experience with the perinatal and breastfeeding phases. Using the Google Forms tool, respondents completed a questionnaire regarding their knowledge, attitudes, and anxiety toward maternal care during the COVID-19 pandemic.

Results:
One hundred eighty-two midwives (99.50%) understood maternal care well during the COVID-19 pandemic. In addition, the maternal care provided during the COVID-19 pandemic was viewed favorably by almost all the participants. The percentage of midwives working in primary care in the perinatal phase who had moderate-to-severe anxiety levels during the COVID-19 pandemic was 17 women (27.42%).

Conclusions:
The knowledge and attitudes of midwives about the COVID-19 pandemic in this study were good, and there was a smaller percentage of midwives with an extreme level of anxiety.
Evaluation of effect of various drinks on tooth surface morphology under scanning electron microscope
Authors: Dixit Seema , Goyal Siddhi , Singh Anshdeep , Dhingra Anil , Grover Sheetal , Gupta Pulkit 
Published: August 2024

Aim and Objectives:
The study aimed to evaluate and compare the effect of various beverages carbonated drinks, i.e., thumps up, fresh fruit juice (apple and pomegranate) and packaged fruit juice (apple and pomegranate) on tooth surface morphology under scanning electron microscope.

Materials and Methods:
Thirty recently extracted intact caries-free human permanent teeth were disinfected with 5.25% of sodium hypochlorite solution and autoclaved at 240°F, 20 psi pressure for 40 min. Each tooth was sectioned into 4 enamel sections yielding 120 sections which were embedded in resin using a prefabricated mold. Prepared samples were immersed as Group I - thumps up, Group II - fresh apple juice, Group III - packaged apple juice, Group IV - fresh pomegranate juice, Group V - packaged pomegranate juice, and Group VI - normal saline. Each immersion was done daily for 30 min over 14 days after which samples were scanned under scanning electron microscope (SEM). The data obtained were subjected to statistical analysis using Statistical Package for the Social Sciences (SPSS Version 23; Chicago Inc., IL, USA).

Results:
The highest surface roughness was noted in the fresh pomegranate and packaged pomegranate groups with a mean of 2.9000 ± 0.30779 followed by thumbs up group. The greatest mean of cracks was noted in thumbs up group with a mean of 2.500 ± 0.51299 which was significant at P = 0.000. The greatest mean of score was noted in thumbs up group with a mean of 2.3000 ± 0.65695 which was significant at P = 0.000.

Conclusion:
The present study demonstrated that all drinks were erosive in nature with thumps and pomegranate juice showing significantly higher erosiveness than apple juice (P < 0.01).
Quantitative evaluation of the apically extruded debris from root canals prepared by single-file rotary and reciprocating file systems: An in vitro study
Authors: Sharma Ayisha , Nirupama Duddi Narendra , Nainan Mohan Thomas , Vijay R. , Thomas Helen , Yasin Sohail 
Published: August 2024

Aim:
The aim is to investigate and compare the amount of apically extruded debris after root canal preparation using single rotary and reciprocating file system.

Materials and Methods:
Forty single-rooted human mandibular premolars with straight canals were randomly assigned to four groups (n = 10). The root canals were instrumented according to the manufacturers’ instructions using single-rotary file systems Hyflex EDM (HEDM), One Shape (OS) and single-reciprocating file systems Wave OneGold (WOG) and OneRECI (OR). The apically extruded debris was collected in preweighed glass vials using the Myers and Montgomery method. After drying, the mean weight of the extruded debris was assessed using a microbalance.

Results and Conclusions:
Multiple comparison between groups demonstrated that the mean weight of apically extruded debris in the HEDM group was significantly less compared to all other study groups, and the differences were statistically significant (P < 0.001). Under the condition of this study, all file systems caused apical debris extrusion. The mean apically extruded debris was significantly least in HEDM, followed by WOG, OneRECI and highest in the OS group.