bluuebunny/crossref_metadata_2025_split huggingface dataset:
Impact of JQ1 treatment on seizures, hippocampal gene expression, and gliosis in a mouse model of temporal lobe epilepsy
Authors: Harnett Aileen , Mathoux Justine , Wilson Marc‐Michel , Heiland Mona , Mamad Omar , Srinivas Sujithra , Sanfeliu Albert , Sanz‐Rodriguez Amaya , How Kelvin Lau E. , Delanty Norman , Cryan Jane , Brett Francesca M. , Farrell Michael A. , O'Brien Donncha F. , Henshall David C. , Brennan Gary P. 
Published: August 2024

AbstractEpilepsy is a neurological disease characterised by recurrent seizures with complex aetiology. Temporal lobe epilepsy, the most common form in adults, can be acquired following brain insults including trauma, stroke, infection or sustained status epilepticus. The mechanisms that give rise to the formation and maintenance of hyperexcitable networks following acquired insults remain unknown, yet an extensive body of literature points towards persistent gene and epigenomic dysregulation as a potential mediator of this dysfunction. While much is known about the function of specific classes of epigenetic regulators (writers and erasers) in epilepsy, much less is known about the enzymes, which read the epigenome and modulate gene expression accordingly. Here, we explore the potential role for the epigenetic reader bromodomain and extra‐terminal domain (BET) proteins in epilepsy. Using the intra‐amygdala kainic acid model of temporal lobe epilepsy, we initially identified widespread dysregulation of important epigenetic regulators including EZH2 and REST as well as altered BRD4 expression in chronically epileptic mice. BRD4 activity was also notably affected by epilepsy‐provoking insults as seen by elevated binding to and transcriptional regulation of the immediate early gene Fos. Despite influencing early aspects of epileptogenesis, blocking BET protein activity with JQ1 had no overt effects on epilepsy development in mice but did alter glial reactivity and influence gene expression patterns, promoting various neurotransmitter signalling mechanisms and inflammatory pathways in the hippocampus. Together, these results confirm that epigenetic reader activity is affected by epilepsy‐provoking brain insults and that BET activity may exert cell‐specific actions on inflammation in epilepsy.
Factors driving microbial biomass and necromass relationships display ecosystem‐dependent responses
Authors: Min Kaikai , Lynch Laurel , Zheng Tiantian , Chen Fusheng , Liang Chao 
Published: August 2024

AbstractMicroorganisms help govern soil organic carbon (SOC) turnover and accumulation. Whilst it is increasingly clear that microbial necromass is a precursor of SOC formation, the relationship between living microorganisms, necromass turnover and SOC persistence remains elusive. In this study, we used phospholipid fatty acids and amino sugars to quantify living versus dead microbial carbon concentrations and evaluated the utility of each pool as an indicator of SOC persistence across a range of climates (low‐, mid‐ and high‐latitude sites) and ecotypes (old‐growth forests vs. managed croplands). We found that microbial necromass was higher in forest than in cropland soils and was positively correlated with soil moisture, SOC and total nitrogen (TN). However, the flow of microbial biomass into necromass and SOC was decoupled in forest sites, likely because the high soil SOC/TN ratio accelerated necromass turnover and recycling by living microorganisms. In contrast, microbial biomass and necromass pools were tightly coupled in croplands and influenced by multiple environmental and biological factors (e.g., necromass concentrations exhibited greater variability in soils with more bacteria than fungi, and those with more gram‐positive than gram‐negative taxa). Contrasting our expectations, the proportion of microbially‐derived necromass in SOC was decoupled from soil properties and microbial biomass in both ecotypes. Whilst SOC and pH appear to be universal drivers of necromass cycling, feedbacks between living biomass, necromass and SOC are shaped by local factors. Our results contribute to ecological theory by highlighting the environmental and biological factors underpinning SOC formation and turnover that can be used to inform land‐management practices that optimize below‐ground carbon sequestration.
Effect of laser irradiation during in‐office tooth bleaching on surface properties of resin‐based restorative materials
Authors: Karanasiou Christina , Dionysopoulos Dimitrios , Mourouzis Petros , Strakas Dimitrios , Naka Olga , Tolidis Kosmas 
Published: August 2024

AbstractThis study evaluated the changes in surface properties of three resin‐based restorative materials after two laser‐assisted, in‐office tooth bleaching protocols using erbium, chromium: yttrium‐scandium‐gallium‐garnet (Er,Cr:YSGG) or diode (980 nm) lasers. A nanohybrid composite (Enamel Plus HRi), a Bis‐GMA‐free composite (Enamel Plus HRi Bio Function), and a resin‐matrix CAD‐CAM ceramic (Shofu Block HC) were tested. Forty specimens for each material were prepared and divided into four groups (n = 10/group). The control specimens did not undergo any bleaching treatment, whereas group 2 received bleaching with 40% hydrogen peroxide (H2O2), while groups 3 and 4 underwent the same bleaching procedure with the use of diode (980 nm) or Er,Cr:YSGG lasers, respectively. Surface microhardness and roughness measurements were conducted using a Vickers tester and an optical profilometer. Microhardness was lower in bleached specimens, with the nanohybrid composite exhibiting the largest difference from the no bleaching group. For the Bis‐GMA‐free composite the microhardness difference between no bleaching and laser‐assisted bleaching were smaller than seen for the conventional bleaching technique. Surface roughness was higher in bleached specimens, with nanohybrid composite showing the largest differences from the control specimens. The examined laser‐assisted tooth bleaching protocols were found not to impact surface microhardness and roughness of the tested resin‐based specimens and they are deemed suitable for clinical use.
Prospect of large language models and natural language processing for lung cancer diagnosis: A systematic review
Authors: Garg Arushi , Gupta Smridhi , Vats Soumya , Handa Palak , Goel Nidhi 
Published: August 2024

AbstractLung cancer, a leading cause of global mortality, demands a combat for its effective prevention, early diagnosis, and advanced treatment methods. Traditional diagnostic methods face limitations in accuracy and efficiency, necessitating innovative solutions. Large Language Models (LLMs) and Natural Language Processing (NLP) offer promising avenues for overcoming these challenges by providing comprehensive insights into medical data and personalizing treatment plans. This systematic review explores the transformative potential of LLMs and NLP in automating lung cancer diagnosis. It evaluates their applications, particularly in medical imaging and the interpretation of complex medical data, and assesses achievements and associated challenges. Emphasizing the critical role of Artificial Intelligence (AI) in medical imaging, the review highlights advancements in lung cancer screening and deep learning approaches. Furthermore, it underscores the importance of on‐going advancements in diagnostic methods and encourages further exploration in this field.
Bolstering family therapy: Assimilating EMDR into ABFT in youth residential treatment
Authors: Dellorco Meredith , Lynch Olivia , Ziegelmeyer Erin , Roeske Michael , Winston‐Lindeboom Payne , Diamond Guy 
Published: August 2024

AbstractThe psychotherapy field has a long history of integration to improve treatment effectiveness. One type, assimilative integration, offers innovative opportunities to family therapy to incorporate the clinical and research contributions of different approaches. This paper contributes to the literature on integration by exploring how Eye Movement Desensitization and Reprocessing (EMDR) can be assimilated into Attachment‐Based Family Therapy (ABFT) for youth in residential psychiatric treatment. ABFT seeks to improve attachment security to parental figures by asking adolescents and young adults to discuss attachment ruptures. This process, specially designed for patients with internalizing disorders, can provoke anxiety, particularly for a patient population that commonly has a history of trauma and adverse life experiences. EMDR is a first‐line therapy for post‐traumatic stress disorder and has the potential to be effective in treating various other mental health conditions. When patient emotional withdrawal or dysregulation due to breaches in trust between child and parent emerges in ABFT, EMDR may help desensitize associated memories and bolster the family therapy process. The authors provide an overview of both models, and a detailed case study as an example. The paper concludes with a discussion on implications, integration efforts, and limitations.
Is women's empowerment enough for intimate partner violence in Muslim‐majority nations?
Authors: Hatun Dogan , Fidan Ahmet 
Published: August 2024

AbstractObjectiveThis study investigates the roles of women's empowerment through employment and decision‐making power on the association between intimate partner violence (IPV) and gender traditionalism in Muslim‐majority nations.BackgroundWomen empowerment and gender ideology perspectives argue that women's resources or egalitarian ideology decrease the IPV that women experience. Many studies, in various nations, found backlash effects where women were exposed to more IPV.MethodUsing Demographic and Health Surveys of Afghanistan 2015 (N = 19,862), Egypt 2014 (N = 6,283), Pakistan 2017–2018 (N = 3,167), and Tajikistan 2017 (N = 4,864) and negative binomial regression analyses, we examined the effects of married women's empowerment on IPV (emotional, physical, sexual, and husbands' controlling behaviors [HCB]).ResultsOverall, we found that women's gender traditionalism increased IPV in all nations. Women's empowerment, however, decreased the total IPV associated with gender traditionalism in four nations, but women's employment increased the total IPV in Egypt.ConclusionsWe conclude that total IPV and HCB are related to gender traditionalism, but they depend on women's empowerment in some Muslim‐majority nations.ImplicationsGovernments might consider making policies that would increase women's knowledge on gender equity and working women's rights, such as including gender quotas in workplaces to empower women. This could lead to a long‐term decrease in attitudes that tolerate IPV.
Climatic Effects on Vapor Flow and Behavior in the Vadose Zone
Authors: Eklund Bart 
Published: August 2024

AbstractThe concentrations and transport of volatile organic compounds (VOCs) and other vapors in the vadose zone may exhibit some degree of temporal variability due to the effect of various climatic factors, including (1) Air temperature; (2) Barometric pressure; (3) Surface winds; and (4) Soil moisture, including the effects of any water infiltration and/or changes in groundwater level. These variables may directly affect the rates of gas transport through the vadose zone or may indirectly affect transport by changing the soil‐gas concentrations at a given location and depth. To understand the potential effect of these factors due to climate change, it is first necessary to understand their effect over typical time periods of one to several days, seasonally, and annually. In this paper, the effects of the above variables over various time periods are presented and the long‐term effects due to climate change are discussed. Standard approaches for soil‐gas measurement attempt to account for these variables, either to negate their potential influence or to capture data under reasonably worst‐case conditions. The appropriateness and adequacy of typical soil vapor measurement approaches are discussed.
Technologies to decontaminate aflatoxins in foods: a review
Authors: Kinyoro Ibrahim Shabani , Kaale Lilian 
Published: August 2024

SummaryAflatoxins are toxic secondary metabolites produced by Aspergillus spp., found in staple food commodities. Aflatoxins are carcinogenic, teratogenic, and mutagenic and pose a serious threat to the health of humans. The identification and quantification of aflatoxins in foods is a major challenge to guarantee food safety. Therefore, developing feasible, sensitive, and robust methods for decontamination is paramount, with short processing time and negligible impact on quality. This review evaluates recent novel technologies for aflatoxins decontamination by physical methods (microwave heating, Gama and electron beam irradiation, pulse light and ultraviolet), chemical methods (ozone, natural plant extracts, and organic acids), and biological methods (atoxigenic Aspergillus strains, Trichoderma spp., and bacteria and yeast). The study highlights on the cutting‐edge technologies of smart packaging and artificial intelligence (AI). To achieve more efficiency and adaptability to different food matrices in aflatoxins decontamination, the study suggests integrating multiple strategies. The study also recommends integrating Partnership for Delivery (P4D) to share the responsibility to increase the chance for success and control aflatoxins in foods.
Bees travelling south: Climate‐induced range shifts and suitable habitat losses in south‐eastern neotropics
Authors: Pereira Felipe W. , Araujo Matheus L. , Brum Fernanda T. , Melo Gabriel A. R. , Moura Mauricio O. , Gonçalves Rodrigo B. 
Published: August 2024

AbstractAimTo provide an assessment of climate change impacts on a set of wild pollinators restricted to one of the regions with the greatest diversity of bees in the world. Also, we aimed to test whether functional groups responded differently to climate projections.LocationSouth‐eastern South America (SES).TaxonBees (Hymenoptera: Apidae sensu lato).MethodsWe selected 18 species of bees mostly restricted to the SES region, modelled their distributions and assessed the possible impacts of near future (2050) climate change in species richness and shifts in range centroids. Potential impacts related to different functional groups were evaluated through t‐tests.ResultsSES species richness was projected to decrease in the northernmost regions and increase southward. Most bee species were predicted to shift their range centroids towards the south‐west and south, while suitable stable areas were found in southern Brazil. We also found higher proportional losses in suitable areas for eusocial species compared to solitary ones, while generalists showed slightly lower gains than specialists.Main ConclusionSES bees are likely to undergo changes in the near future, with projected losses of species at northern portions and southward increases. The identified stable areas in southern Brazil underscore the importance of conservation efforts in the region, particularly in natural grasslands – an endangered habitat with high bee diversity. Although our results suggest higher vulnerability for functional groups traditionally considered more resilient, it is essential to acknowledge that other factors, including habitat and mutualists availability, behavioural particularities, phenology and range size, must be determinants for the vulnerability of species to ongoing climate change.
Effectiveness of community‐based hypertension management on hypertension in the urban slums of Haiti: A mixed methods study
Authors: St Sauveur Reichling , Sufra Rodney , Jean Pierre Marie Christine , Rouzier Vanessa , Preval Fabiola , Exantus Serfine , Jean Mirline , Jean Josette , Forestal Guyrlaine Pierre‐Louise , Fleurijean Obed , Mourra Nour , Ogyu Anju , Malebranche Rodolphe , Brisma Jean Pierre , Deschamps Marie M. , Pape Jean W. , Sundararajan Radhika , McNairy Margaret L. , Yan Lily D. 
Published: August 2024

AbstractHypertension is a leading contributor to mortality in low‐middle income countries including Haiti, yet only 13% achieve blood pressure (BP) control. We evaluated the effectiveness of a community‐based hypertension management program delivered by community health workers (CHWs) and physicians among 100 adults with uncontrolled hypertension from the Haiti Cardiovascular Disease Cohort. The 12‐month intervention included: community follow‐up visits with CHWs (1 month if BP uncontrolled ≥140/90, 3 months otherwise) for BP measurement, lifestyle counseling, medication delivery, and dose adjustments. Primary outcome was mean change in systolic BP from enrollment to 12 months. Secondary outcomes were mean change in diastolic BP, BP control, acceptability, feasibility, and adverse events. We compared outcomes to 100 age, sex, and baseline BP matched controls with standard of care: clinic follow‐up visits with physicians every 3 months. We also conducted qualitative interviews with participants and providers. Among 200 adults, median age was 59 years, 59% were female. Baseline mean BP was 154/89 mmHg intervention versus 153/88 mmHg control. At 12 months, the difference in SBP change between groups was −12.8 mmHg (95%CI −6.9, −18.7) and for DBP −7.1 mmHg (95%CI −3.3, −11.0). BP control increased from 0% to 58.1% in intervention, and 28.4% in control group. Four participants reported mild adverse events. In mixed methods analysis, we found community‐based delivery addressed multiple participant barriers to care, and task‐shifting with strong teamwork enhanced medication adherence. Community‐based hypertension management using task‐shifting with CHWs and community‐based care was acceptable, and effective in reducing SBP, DBP, and increasing BP control.
Influence of dental midline deviation with respect to facial flow line on smile esthetics—A cross‐sectional study
Authors: Tahir Kanza , Barakaat Afeefa Abul , Shaukat Umair , Maaz Muhammad , Fida Mubassar , Sukhia Rashna Hoshang 
Published: August 2024

AbstractBackground/ObjectiveA contemporary concept states that dental midline deviation towards the direction of facial flow line (FFL) can mask the compromised smile esthetics. This study aimed to identify a range of midline deviations that can be perceived towards or away from the FFL influencing smile esthetics.Materials and MethodsA cross‐sectional study was conducted using a frontal smile photograph of an adult female. The photograph was altered on Adobe Photoshop software into six different photographs by deviating the dental midlines towards and away from the FFL. A constant deviation of chin towards the left side was incorporated in all the photographs. Forty‐three laypersons (LP) and dental professionals (DPs) evaluated those photographs. Independent t‐test was used to compare the perception of dental midline deviation between LP and DPs. Simple linear regression was run to identify the factors associated with the scoring.ResultsA statistically significant difference was observed for picture two with 4 mm towards FFL in the perception of midline deviation between LP and DPs. LP could not perceive the midline deviations up to 4 mm while DPs were able to perceive deviations above 2 mm. The greater the age the better the scores were and female raters had a greater inclination towards poor scores.ConclusionsFrom 2 to 4 mm of midline deviation towards the FFL can be tolerated by LP and DPs.Clinical SignificanceThese findings underscore the importance of considering facial symmetry in orthodontic and cosmetic dental treatments to optimize smile esthetics.
An integrated urban metabolism and ecosystem service assessment: The case study of Lima, Peru
Authors: Cárdenas‐Mamani Úrsula , Perrotti Daniela 
Published: August 2024

AbstractAgainst the backdrop of urbanization and its environmental impacts, this study expands urban metabolism research by integrating knowledge from the ecosystem service (ES) concept. A framework was put forward to capitalize on ES knowledge in metabolic studies and material flow analysis in particular while supporting dynamic analysis of ES supply and demand flows through factors such as pressure, state, and drivers. This framework is tested in the city of Lima, Peru, to evaluate six ESs and express their contribution in a standard economy‐wide material flow analysis of the city. Moreover, simulations were deployed to forecast spatiotemporal variations of resource flows and emissions until the year 2050. Findings indicate a gap between the city's ES demand and the availability of its local natural resources. Demand exceeds local supply ES flows in Lima, with the exception of surface water provision and cane‐mats for construction materials, representing 141% and 128% of the total supply, respectively. However, they are projected to reduce by the year 2050: 19% and 22% respectively. Carbon sequestration supply represents 0.01% of the total demand (carbon emissions). Peri‐urban agriculture production represents 4.3% of the total food consumption. Our findings offer a new perspective on the role of nature in cities and highlight the need to implement urban sustainability policies that can help overcome metabolic deficiencies while prioritizing resource efficiency, decarbonization, and conservation/generation of green infrastructure in the city.
Prospective life cycle assessment of climate and biodiversity impacts of meat‐based and plant‐forward meals: A case study of Indonesian and German meal options
Authors: Marquardt Sandra G. , Joyce P. James , Rigarlsford Giles , Dötsch‐Klerk Mariska , van Elk Kathelijn , Doelman Jonathan , Daioglou Vassilis , Huijbregts Mark A. J. , Sim Sarah 
Published: August 2024

AbstractThe emerging field of prospective life cycle assessment (pLCA) offers opportunities for evaluating the environmental impacts of possible future consumption shifts. One such shift involves a transition from meat‐based to plant‐forward diets, acknowledged to mitigate environmental impacts of the food system under present day conditions. Current diets are often meat intensive (“meat‐based”), whilst “plant‐forward” diets include mainly plant‐based foods, encompassing flexitarian, vegetarian, and vegan diets. Here we illustrate the application of pLCA in a case study of meal options, implementing shared socio‐economic pathway scenarios in the LCA background system to represent future production conditions. We assess the climate footprints and land‐based biodiversity footprints of a typical meat‐based meal in Germany and Indonesia compared to a plant‐forward meal in both countries (i.e., four meals), now and in 2050. Our findings show that the plant‐forward alternative maintains a lower impact per serving in all future scenarios. At the same time, the reduction in impact for the meat‐based meals is more pronounced in future scenarios due to shifts in the agricultural system. Our findings highlight the importance of supply‐side measures to produce lower‐impact ingredients, complementing demand‐side interventions to reshape food consumption. Results are further evaluated in cultural and nutritional contexts, highlighting the practical decision‐making constraints faced by consumers. We find potential “leakage” effects in calories and nutrition when choosing a lower‐impact, plant‐forward meal. These leakage effects should be considered in future studies seeking to evaluate the environmental implications of meal substitutions in the context of broader dietary requirements.