bluuebunny/crossref_metadata_2025_split huggingface dataset:
Hybrid Intelligent Model to provide valuable insights and information for Decision-making in the Early Stages of Projects Portfolio.
(Case Study: Automotive Industry)
Authors: Faridnia Rashid 
Published: August 2024

Abstract

This study proposes a novel approach for intelligent decision-making in automotive platform-based projects by integrating advanced techniques such as Long Short-Term Memory (LSTM) for time series forecasting, Genetic Algorithms for portfolio optimization, and Multi-Objective Optimization for balancing conflicting objectives. The use of LSTM enables accurate prediction of future trends in automotive platform performance metrics, while Genetic Algorithms efficiently search for the optimal portfolio composition that maximizes returns and minimizes costs. By incorporating Multi-Objective Optimization, decision-makers can explore trade-offs between multiple objectives such as maximizing returns, minimizing costs, and ensuring diversification. The proposed framework offers a comprehensive solution for optimizing automotive platform portfolios and facilitating strategic decision-making in the automotive industry projects.
Numerical simulation of morphological evolution in a gravel-bed meandering river during floods: a case study on the Sai-Jiang river
Authors: Dengsong Li , Tingting Liao , Weifang Ruan , Lijuan Wang , Qing Yang , Jiajie Mao , Miao Huo , Jiuzhou Huang 
Published: August 2024

ABSTRACT

The water velocity undergoes a significant increase during the initial stage of floods. The present study focuses on investigating the scours and silting occurring in an S-shaped gravel-bed river. The primary objective is to analyze the impact of 10-year flood events on both the riverbed and bank stability. This river is located in the Sai-jiang River reach, Fujian Province, China. A numerical model of riverbed scours and silting is herein tested. The research results indicate that the morphological evolution of the whole river section is affected in the early stage of flood evolution; however, in the later stage, some key places such as the bridge and the river land are still greatly affected. The apex of the river bend is in close proximity to the downstream river island, resulting in scour at the head of the river island that deviates from conventional patterns of head scour and tail siting. Furthermore, the presence of artificial structures like bridges exacerbates the scour and silting processes in river beds during flood events. For this case, the riverbed adjacent to the Banzhong Bridge pier experienced a widening of approximately 50 m and downstream extension of around 300 m, with a maximum vertical scouring depth of 2.87 m.
Prostaglandins in the Inflamed Central Nervous System: Potential Therapeutic Targets
Authors: Sheremeta Chynna-Loren , Yarlagadda Sai , Smythe Mark L. , Noakes Peter G. 
Published: August 2024

:
The global burden of neurological disorders is evident, yet there remains limited efficacious
therapeutics for their treatment. There is a growing recognition of the role of inflammation
in diseases of the central nervous system (CNS); among the numerous inflammatory mediators involved,
prostaglandins play a crucial role. Prostaglandins are small lipid mediators derived from
arachidonic acid via multi-enzymatic pathways. The actions of prostaglandins are varied, with
each prostaglandin having a specific role in maintaining homeostasis. In the CNS, prostaglandins
can have neuroprotective or neurotoxic properties depending on their specific G-protein receptor.
These G-protein receptors have varying subfamilies, tissue distribution, and signal transduction
cascades. Further studies into the impact of prostaglandins in CNS-based diseases may contribute
to the clarification of their actions, hopefully leading to the development of efficacious therapeutic
strategies. This review focuses on the roles played by prostaglandins in neural degeneration, with
a focus on Alzheimer’s Disease, Multiple Sclerosis, and Amyotrophic Lateral Sclerosis in both
preclinical and clinical settings. We further discuss current prostaglandin-related agonists and antagonists
concerning suggestions for their use as future therapeutics.
PLCG2, A Regulator of Lung Adenocarcinoma Proliferation and Migration Associated with Immune Infiltration
Authors: Chen Shuhui , Zhou Chenkang , Dai Jieying , Xu Qingqing , Chen Yuxin , hu Zhaoting , Wang Yumin , Wang Caihong 
Published: August 2024

Background:
Results from the TCGA database showed that phosphatidylinositol-specific phospholipase Cγ2 (PLCG2) expression level in Lung Adenocarcinoma (LUAD) was notably decreased compared to adjacent tissues, so we unveiled its role of LUAD.

Objective:
This study aims to explore the expression and clinical significance of Phosphatidyl-inositol-specific phospholipase Cγ2 (PLCG2) in lung adenocarcinoma (LUAD) cells and its role in cell proliferation and metastasis.

Methods:
Differential PLCG2 mRNA and protein levels between LUAD tissues and adjacent tissues were analyzed from the TCGA database, TIMER, and UALCAN database. Differentially expressed genes were screened for patients in the high and low PLCG2 mRNA expression groups by the R package as well as GSEA. The expression level of PLCG2 in LUAD cells was detected using qRT-PCR and CCK8, clone formation, Transwell, and Western blot assays.

Results:
PLCG2 was lowly expressed in LUAD and did not significantly correlate with the prognosis of LUAD. PLCG2 expression levels varied significantly in terms of patients' gender, age, T, N, and pathological stage. GO/KEGG enrichment analysis showed that co-expression of PLCG2 was mainly associated with the immune response- regulating cell-surface receptors, and so on. GSEA analysis showed enrichment pathways of PLCG2-related differential gees were primarily associated with the olfactory transduction pathway, ribosome, etc. R software analysis revealed a significant correlation between PLCG2 expression and six types of immune-infiltrat-ing cells, positively correlated with immune checkpoint-related genes and negatively regulated by tumor mutational load. Overexpressing PLCG2 showed reduced LUAD cell proliferation, clone formation, cell migration and invasion, and epithelial-mesenchymal transition-associated proteins, compared with the control group.

Conclusion:
PLCG2 is lowly expressed in LUAD tissues and is involved in immune infiltration of LUAD, inhibiting LUAD cell proliferation and metastasis.
Protective Effects of Chitosan-Loaded Pomegranate Peel Extract Nanoparticles on Infertility in Diabetic Male Rats
Authors: Said Farah , Omar Amel Ramadan , Mohamed Ayman Saber , Dakrory Ahmed Imam , Abdelaziz Mennatallah H. 
Published: August 2024

Background:
Diabetes Mellitus (DM) is known to have an impact on the health of the
male reproductive system. It is linked to low sperm quality, increased oxidative stress, and an
increased generation of reactive oxygen species in the seminal fluid. Pomegranate extract has
phenolic compounds and significant protective properties against oxidative stress, male sex
hormone disruptions, and sperm abnormalities.

Objective:
The current study aimed to evaluate the effectiveness of Pomegranate Peel Extract
Nanoparticles (PPENPs) on male fertility in diabetic rats.

Methods:
DM was induced in rats by intraperitoneal injection of streptozotocin (60 mg/kg).
Twenty-four rats were divided into four groups, 6 rats in each group: control, DM, DM+empty
NPs (60 mg/kg, orally), and DM+PPENPs (60 mg/kg, orally).

Results:
Administration of PPENPs increased the levels of insulin, FSH, LH, testosterone,
catalase, glutathione reduced, and semen fructose. PPENPs also improved sperm quality, as seen
by improvements in sperm morphology, motility, count, and the ability of metabolically active
spermatozoa to convert blue resazurin dye to pink resorufin. However, PPENPs decreased levels
of glucose, malonaldehyde, nitric oxide, and sperm abnormalities. Also, histological investigation
of the PPENPs showed improvement in testis tissue architecture and increased the diameter size of
seminiferous tubules and germinative layer thickness.

Conclusion:
Our investigation proved that the treatment of PPENPs has a protective effect on the
reproductive system of male diabetic rats, improving fertility parameters, healthy sperm profiles,
and the antioxidant system.
Investigation of the Permeability of Antiretroviral Drugs Lamivudine and Valganciclovir via Single-Pass Intestinal Perfusion (SPIP) Method
Authors: Sanlı Senem , Kaynak Mustafa Sinan , Sanlı Nurullah , Balta Emine Erturk 
Published: August 2024

Introduction:
Antiretroviral medications are widely used to treat HIV infections.
Lamivudine (3TC) is prescribed for HIV-1 infection management in adults and pediatrics,
while valganciclovir (VGC) is a prodrug of ganciclovir derived from valine.

Methods:
The Biopharmaceutics Classification System (BCS) estimates the contributions of
intestinal permeability, dissolution, and solubility in oral drug absorption. Intestinal permeability
refers to a substance's capacity to pass through the protective layer of cells in the intestine.
The intestinal permeability of 3TC and VGC was analyzed and categorized using the singlepass
intestinal perfusion technique according to the BCS in male Sprague Dawley rats, and a
reversed-phase HPLC method was validated for precise and accurate measurement.

Results:
According to the BCS, 3TC and VGC have been classified as having low permeability
when compared to metoprolol tartrate, which is classified as Class I with good permeability
and resolution.

Conclusion:
The permeability values derived from this work can be valuable in exposure assessment
models.
A Comparative Analysis on the Effects of Two Different Grafts on Gingival Phenotype, Dentin Hypersensitivity, and Quality of Life: A 6-month Split-mouth Study
Authors: Fartes Otávio Alberto da Costa , Baroudi Kusai , Cortelli Sheila Cavalca , Costa Fernando Oliveira , Nascimento Júlia Aparecida do , Silva Jesca Neftali Nogueira , Cortelli José Roberto 
Published: August 2024

Objective
This study aimed to compare the effects of two surgical treatments of multiple gingival recessions on gingival phenotype over 6 months. Moreover, dentin hypersensitivity and quality of life scores were also monitored over time.

Materials and Methods
In this longitudinal split-mouth study, 90 upper-class Recession Type 2 (RT2) bilateral gingival recessions (GR) were randomly (right or left side) assigned to coronally advanced flaps with connective tissue graft (CTG group) or xenogeneic collagen matrix (XCM group). The primary outcome was GR reduction after surgical procedures. At the preoperative visit, 3- and 6-months gingival thickness through cone-beam computed tomography using lip retractors were determined. Oral health-related quality of life (OHRQoL) and stimulated dentin hypersensitivity were evaluated by the Oral Health Impact Profile (OHIP-14) instrument and visual analogic scale, respectively.

Results
A thicker gingival phenotype was seen at 6 months, indicating phenotype improvement. Both techniques showed similar results (p > 0.05) over time regarding root covering (CTG = 74.19% and XCM = 77.41%). At 6 months, dentin hypersensitivity only decreased in the XCM group. Independently of the treatment group, statistically significant improvements were observed (Friedman test; p < 0.05) in physical pain and limitation, psychological discomfort, and limitation domains favoring OHRQoL.

Conclusion
Gingival phenotype improved over time independently of the technique. Both surgical treatments provided similar and adequate recovery of multiple gingival recessions. At 6 months, patients experienced a better quality of life profile related to oral health. Moreover, the XCM group experienced lower dentin hypersensitivity.
Challenges Faced by International Students in Cyprus Amid the COVID-19 Pandemic: Exploring Social Identity Loss and Reverse Culture Shock
Authors: Okoli JohnPaul Chika , Nweke Gabriel Elochukwu 
Published: August 2024

Introduction
The global COVID-19 pandemic introduced unprecedented challenges for international students, particularly those studying in Cyprus. This study explores the impact on international students, focusing on Social Identity Loss (SIL) and Reverse Culture Shock (RCS) as critical themes. The objective is to illuminate the experiences of students navigating life transitions during the pandemic.

Methods
The qualitative methodology employed in-depth semi-structured interviews, both in person and online, with thematic analysis revealing key study themes. The findings highlight the significant correlation between isolation, detachment, and a sense of belonging with SIL and RCS (H1), with a correlation value of 1.0 and significance at 0.01 level, emphasizing the negative impact. Conversely, active participation in virtual communities and online cultural integration programs (H3) has positive effects in reducing SIL and RCS as correlation values were 0.72. Pearson correlation coefficients provide insights into relationships between variables and SIL/RCS, emphasizing the importance of fostering a sense of belonging. Regression analysis identifies Corporate Social Responsibility (CSR) as an unexpected factor exacerbating challenges as it demonstrates a positive coefficient of 0.3690, and H1 emerges as a critical predictor.

Results
These findings underscore the need for tailored support mechanisms and interventions to address the unique needs of international students in Cyprus during the COVID-19 pandemic.

Conclusion
Overall, this study contributes to a deeper understanding of the challenges faced by international students and provides a foundation for developing effective strategies to support their well-being and academic success in an evolving global landscape.
Combined Phloretin and Human Platelet-rich Plasma Effectively Preserved Integrities of Brain Structure and Neurological Function in Rat after Traumatic Brain Damage
Authors: Lin Kun-Chen , Chen Kuan-Hung , Shao Pei-Lin , Chai Han-Tan , Sung Pei-Hsun , Chiang John Y. , Ko Sheung-Fat , Yip Hon-Kan 
Published: August 2024

Background:
This study investigates whether phloretin, a brain-edema inhibitor, can enhance the therapeutic effects of human-derived platelet-rich plasma
(hPRP) in reducing brain hemorrhagic volume (BHV) and preserving neurological function in rodents following acute traumatic brain damage
(TBD).

Methods:
Forty rats were divided into five groups: sham-control, TBD, TBD + phloretin (80 mg/kg/dose intraperitoneally at 30 minutes and on days 2/3
post-TBD), TBD + hPRP (80μL by left intra-carotid-artery injection at 3 hours post-TBD), and TBD + phloretin + hPRP. Cerebral tissues were
harvested on day 28 post-TBD for analysis.

Results:
Brain MRI on day 28 showed the lowest BHV in the sham-control group and the highest in the TBD group. BHV was significantly lower in the
phloretin + hPRP group compared to the phloretin or hPRP alone groups, which had similar BHV. Neurological function followed an inverse
pattern to BHV. By day 28, protein levels of upstream (HGMB1, TLR-2, TLR-4, MyD88, Mal, TRAM, TRIF, TRAF6, IKK-α, IKK-ß, p-NF-κB)
and downstream (IL-1ß, TNF-α, iNOS) inflammation signalings, apoptosis (caspase3, PARP), and fibrosis (Smad3, TGF-ß) biomarkers, as well as
flow cytometric assessment of inflammatory cells (CD11b/c+, Ly6G+, PMO+) and early (AN-V+/PI-) and late (AN-V+/PI+) mononuclear-cell
apoptosis, displayed patterns similar to BHV. The number of inflammatory (CD68+, MMP9+) and brain-swelling/myelin-damaged (AQP4+,
GFAP+) mediators also followed this pattern, while neuronal-myelin (Doublecortin+, NeuN, nestin) mediators showed an inverse relationship with
BHV (all p<0.0001).

Conclusion:
Combined phloretin and hPRP therapy is superior to either treatment alone in protecting the brain against TBD, primarily by suppressing
inflammatory signaling and brain-swelling biomarkers.
Dental Students Stress during Clinical Restorative Procedures: A Saudi-Based Study
Authors: Aljanakh Mohammad D. 
Published: August 2024

Objectives
The study aims to assess the clinical restorative dental procedures’ impact on the stress levels of Saudi dental students and explore variations in student year levels, genders, and restorative procedures.

Methods
An observational cross-sectional study was conducted using census sampling in 2023 at the College of Dentistry, University of Ha’il, Saudi Arabia. Out of 120 students, 105 completed the questionnaire. This questionnaire comprised thirteen questions that assessed stress levels using a 7-point Likert scale categorized into three types of dental procedures: diagnosis, operative, and endodontics. Descriptive statistics, Mann-Whitney U, Kruskal-Wallis, and Friedman tests were used to explore gender, students' year levels, and restorative category variations.

Results
The response rate was 87.5% of all students. The students’ stress levels declined for all year levels and categories. No significant gender differences were found, except for fifth-year female students who reported higher stress levels in the endodontic category (p =.032). There were no significant differences in students' stress levels, except for third-year students, who reported higher stress levels in the operative category than fifth-year students (p =.01). The operative and endodontic categories had significantly higher impacts on perceived stress levels among all students compared to the diagnostic category (p =.001, p =.001, respectively).

Conclusion
The stress levels were declining as students advanced in academic year levels with variations in different restorative procedures with no significant overall gender differences. The findings recommend curriculum adjustments and targeted support for dental students.
Penerapan Model Contextual Teaching Learning Berbantuan Komika (Komik Matematika) untuk Siswa Sekolah Dasar
Authors: Aprilia Tika 
Published: August 2024

This study aimed to describe the improvement of mathematics learning outcomes in grade V at SDN Gajahmungkur 02 Semarang. This research was a classroom action research conducted in 3 cycles, each cycle consists of two meetings. The results showed that: (1) teacher skills in the first cycle score was 35,5 (good); in the second cycle score was 43,5 (very good); and in the third cycle score was 47 (very good), (2) students’ activity in the first cycle score was 28,2 (good); in the second cycle score was 31,2 (very good); and in the third cycle score was 34,8 (very good), (3) learning ambiance in first cycle obtained 5,5 (good); in the second cycle got 6,5 (very good); and in the third cycle reached 7,5 (very good), (4) learning material in first cycle obtained 6 (very good); in the second cycle got 6,5 (very good); and in the third cycle reached 8 (very good), (5) learning media in first cycle obtained 8 (good); in the second cycle got 10 (very good); and in the third cycle reached 12 (very good), (6) learning result of students’ learning outcome in first cycle obtained 69,2%; in the second cycle got 76,9%; and in the third cycle reached 88,5%. Thus, the application of the contextual teaching learning model assisted by mathematics comic media can improve student learning outcomes. Keywords: Contextual Teaching Learning, Mathematical Comics, Student Learning Outcomes, Elementary School========================================================================================================Tujuan penelitian ini adalah mendeskripsikan peningkatan hasil belajar matematika pada siswa kelas V SDN Gajahmungkur 02 Semarang. Penelitian ini merupakan penelitian tindakan kelas yang dilaksanakan 3 siklus, setiap siklus terdiri dari 2 pertemuan. Hasil penelitian menunjukkan: (1) keterampilan guru siklus I skornya 35,5 (baik), siklus II skornya 43,5 (sangat baik), siklus III skornya 47 (sangat baik), (2) aktivitas siswa siklus I skornya 28,2 (baik), siklus II skornya 31,2 (baik), siklus III skornya 34,8 (sangat baik), (3) iklim pembelajaran siklus I skornya 5,5 (baik), siklus II 6,5 (sangat baik), siklus III 7,5 (sangat baik), (4) materi pembelajaran siklus I skornya 6 (sangat baik), siklus II 6,5 (sangat baik), siklus III 8 (sangat baik), (5) media pembelajaran siklus I skornya 8 (baik), siklus II 10 (sangat baik), siklus III 12 (sangat baik), (6) hasil belajar siklus I memperoleh ketuntasan belajar 69,2%, siklus II 76,9%, siklus III 88,5%. Dengan demikian penerapan model contextual teaching learning berbantuan media komik matematika dapat meningkatkan hasil belajar siswa. Kata kunci: Contextual Teaching Learning, Komik Matematika, Hasil Belajar Siswa, Sekolah Dasar
Implementasi Pendekatan Scientific dalam Pembelajaran Bahasa Jawa
Authors: Ono Budi , Wiyani Novan Ardy , Setiani Made Yudhi 
Published: August 2024

This study aimed to analyze the application of the scientific learning model in Javanese language learning. This research uses a qualitative approach with the type of case study research. Data were collected by interview, observation, and documentation. Data analysis is carried out using three stages: reducing data, presenting data, and making conclusions or verification. The results showed that implementing the scientific approach in learning Javanese language class V at SD Negeri Karanganyar Purbalingga was carried out through five stages: observing, asking, exploring, associating, and communicating activities. In the following actions, the teacher determines the real object of observation to foster curiosity and utilize the media so that learning is not stuck with textbooks. In the questioning activity, the teacher gives students the freedom to ask questions related to the studied material. In addition, the teacher also provides questions that explore high-level cognitive abilities. In exploring activities, the teacher explores information from students about learning materials. The activities are conducted through experiments, associating teachers, and designing teaching materials according to the 2013 curriculum. Then in communication activities, the teacher gives students the freedom to convey the results of their observations orally and in writing. Keywords: observing, questioning, exploring, associating, communicating =====================================================Tujuan penelitian ini adalah untuk menganalisis penerapan model pembelajaran saintifik dalam pembelajaran Bahasa Jawa. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian studi kasus. Data dikumpulkan dengan wawancara, observasi, dan dokumentasi. Analis data dilakukan dengan menggunakan tiga tahap yaitu mereduksi data, menyajikan data, dan membuat kesimpulan atau verifikasi. Hasil penelitian menunjukkan bahwa implementasi pendekatan scientifik dalam pembelajaran bahasa Jawa kelas V di SD Negeri Karanganyar Purbalingga dilakukan melalui lima tahapan,yaitu kegiatan mengamati, menanya, mengeksplorasi, mengasosiasi, dan mengkomunikasikan. Pada kegiatan mengamati, guru menentukan objek pengamatan yang nyata untuk menumbuhkan rasa ingin tahu dan memanfaatkan media sehingga pembelajaran tidak terpaku dengan buku teks. Pada kegiatan menanya, guru memberikan kebebasan peserta didik mengutarakan pertanyaan terkait materi yang dipelajari. Selain itu guru juga memberikan pertanyaan yang menggali kemampuan kognitif tingkat tinggi. Pada kegiatan mengeksplorasi, guru menggali informasi dari peserta didik tentang materi pembelajaran, dimana kegiatan itu dilakukan melalui eksperimen. Pada kegiatan mengasosiasi guru merancang bahan ajar sesuai kurikulum 2013. Kemudian pada kegiatan mengkomunikasikan, guru memberikan kebebasan peserta didik untuk menyampaikan hasil pengamatan secara lisan dan tertulis. Kata kunci: mengamati, menanya, mengeksplorasi, mengasosiasi, mengkomunikasikan