bluuebunny/crossref_metadata_2025_split huggingface dataset:
Case of primary cutaneous peripheral T‐cell lymphoma, not otherwise specified, with characteristics of follicular helper T cells
Authors: Takaki Machiko , Inozume Takashi , Matsuzawa Takamitsu , Ando Noriko , Yamaguchi Miyuki , Harada Kazutoshi , Kawamura Tatsuyoshi , Shibagaki Naotaka , Shimada Shinji 
Published: May 2014

AbstractWe report a case of an 88‐year‐old woman with a decalvant, erythematous, ulcerated tumor extending from the right temporal to occipital region. Histopathological analysis revealed a dense infiltration of medium‐to‐large‐sized atypical cells throughout the entire dermis. The result of immunohistochemical analysis showed that the infiltrating T cells expressed programmed death‐1 (PD‐1), Bcl‐6 and CXCL13. Flow cytometry analysis showed that CD4+ PD‐1hi T cells also expressed CD10, inducible T‐cell co‐stimulator and CXCR5. On the basis of the clinical appearance and the histopathological findings, we diagnosed the patient with primary cutaneous peripheral T‐cell lymphoma, not otherwise specified. Recently, the concept of primary cutaneous follicular helper T (TFH)‐cell lymphoma was proposed, and in this case, tumor cells clearly expressed TFH‐cell markers. Therefore, we considered this case to be a variant of the entity. Although this entity is still provisional, this case supports the new concept.
Successful use of intravenous cyclophosphamide pulse therapy for interstitial lung disease in a patient with systemic sclerosis on hemodialysis
Authors: Takahashi Takehiro , Asano Yoshihide , Sunaga Ryo , Ichimura Yohei , Taniguchi Takashi , Yamamoto Mizuho , Tamaki Zenshiro , Takekoshi Tomonori , Mitsui Hiroshi , Sugaya Makoto , Ohse Takamoto , Sato Shinichi 
Published: May 2014

AbstractInterstitial lung disease and scleroderma renal crisis are major complications of systemic sclerosis, which occasionally coexist in patients with the diffuse cutaneous subtype. We herein report a case of diffuse cutaneous systemic sclerosis under hemodialysis due to a previous history of scleroderma renal crisis, whose interstitial lung disease was effectively and safely treated with a half dose of i.v. cyclophosphamide pulse. The dose of cyclophosphamide and the timing of hemodialysis leading to efficacy and low toxicity are discussed.
Oral S‐1 in advanced cutaneous squamous cell carcinoma
Authors: Teramoto Yukiko , Nakamura Yasuhiro , Yamada Katsuhiro , Yamamoto Akifumi 
Published: May 2014

AbstractSquamous cell carcinoma (SCC) is the second most common type of skin cancer in Japan, and its incidence has been increasing in recent years. Early diagnosis and complete excision can provide a high cure rate. However, advanced cases of SCC showing local invasion, regional lymph node metastasis or distant metastasis are not curative and are difficult to treat with surgery alone. Some chemotherapy regimens have been used for treating advanced cutaneous SCC. However, almost all these regimens require intravenous administration and result in serious toxicities in elderly people. We gave S‐1, a novel oral chemotherapeutic agent, for six patients with advanced cutaneous SCC. Three patients achieved complete response and one achieved partial response. Two patients showed stable disease. The overall response rate was 66.7% (four of six patients), and the disease control rate was 100%. Two of six patients developed grade 3 anaemia. Oral S‐1 treatment is safe and effective for treating advanced cutaneous SCC. However, a prospective trial is necessary to confirm the effectiveness of oral S‐1 for advanced cutaneous SCC.
Clinical profiles of Stevens–Johnson syndrome among Thai patients
Authors: Limpawattana Panita , Choonhakarn Charoen , Kongbunkiat Kannikar 
Published: May 2014

AbstractThe objective of this study was to demonstrate the clinical profiles of Stevens–Johnson syndrome (SJS) in Thai patients, and to compare those clinical features between younger and older patients. Medical records of all patients with SJS who were admitted to Srinagarind Hospital Medical School, Khon Kaen, Thailand, from January 2002 to December 2014 were reviewed. Epidemiological features, etiologies, treatment and clinical outcomes were collected. There were 45 patients with SJS during the 10‐year period. Females were the majority (57.8%) and the median age was 49 years. Hepatitis was the most frequent complication (67.5%). Phenytoin (15.6%), sulfonamide drugs (15.6%) and allopurinol (13.3%) were implicated as leading causes of SJS. Steroids were prescribed in 37 cases (82.2%). The mortality rate was 4.4%. Comparing older patients to younger patients, allopurinol appeared to be the main instigating drug to develop SJS with an odds ratio of 5.6 (95% confidence interval, 2.8–10.6). In conclusion, clinical features of Thai patients with SJS were similar to other reports. Allopurinol had the strongest association with SJS in older patients as compared to the younger ones.
Case of generalized pustular psoriasis with end‐stage renal disease successfully treated with granulocyte monocyte apheresis in combination with hemodialysis
Authors: Mabuchi Tomotaka , Manabe Yasuaki , Yamaoka Hanako , Ota Tami , Kato Masayuki , Ikoma Norihiro , Kusakabe Yoshiyuki , Komaba Hirotaka , Ozawa Akira 
Published: May 2014

AbstractGranulocyte monocyte apheresis (GMA) is an extracorporeal apheresis instrument that removes activated neutrophils and monocytes. Generalized pustular psoriasis (GPP) is characterized by neutrophil infiltration into the epidermis that causes Kogoj's spongiotic pustule. Thus, GMA is one of the useful therapies for GPP, and it was approved for the treatment in 2012 in Japan. Herein, we report a case of GPP with end‐stage renal disease (ESRD) successfully treated with GMA in combination with hemodialysis (HD). A 54‐year‐old Japanese female visited our outpatient clinic because of erythema with pustules on her trunk and extremities over the past 4 months. Histopathological examination showed an intraepidermal pustule filled with numerous neutrophils and spongiosis. These findings led to the diagnosis of GPP. She had ESRD and had been treated with HD twice a week for approximately 4 years. During maintenance HD twice a week, weekly GMA was started at Tokai University Hospital. The skin symptoms disappeared after five administrations of GMA. We suggest that GMA is an effective therapy for GPP patients with ESRD who are treated with HD.
Spatial Variability in Litterfall, Litter Standing Crop and Litter Quality in a Tropical Rain Forest Region
Authors: Parsons Scott A. , Congdon Robert A. , Shoo Luke P. , Valdez‐Ramirez Vanessa , Williams Stephen E. 
Published: May 2014

AbstractUnderstanding the spatial variability in plant litter processes is essential for accurate comprehension of biogeochemical cycles and ecosystem function. We assessed spatial patterns in litter processes from local to regional scales, at sites throughout the wet tropical rain forests of northern Australia. We aimed to determine the controls (e.g., climate, soil, plant community composition) on annual litter standing crop, annual litterfall rate and in situ leaf litter decomposability. The level of spatial variance in these components, and leaf litter N, P, Ca, lignin, α‐cellulose and total phenolics, was determined from within the scale of subregion, to site (1 km transects) to local/plot (~30 m2). Overall, standing crop was modeled with litterfall and its chemical composition, in situ decomposability, soil Na, and topography (r2 = 0.69, 36 plots). Litterfall was most closely aligned with plant species richness and stem density (negative correlation); leaf decomposability with leaf‐P and lignin, soil Na, and dry season moisture (r2 = 0.89, 40 plots). The predominant scale of variability in litterfall rates was local (plot), while litter standing crop and α‐cellulose variability was more evenly distributed across spatial scales. Litter decomposability, N, P and phenolics were more aligned with subregional differences. Leaf litter C, lignin and Ca varied most at the site level, suggesting more local controls. We show that variability in litter quality and decomposability are more easily accounted for spatially than litterfall rates, which vary widely over short distances possibly in response to idiosyncratic patterns of disturbance.
Rotation thromboelastometry and the hypercoagulable state in Cushing's syndrome
Authors: Alves Coelho Maria Caroline , Vieira Neto Leonardo , Kasuki Leandro , Wildemberg Luiz Eduardo , dos Santos Camila Vicente , Castro Gizele , Gouvêa Glauber , Veloso Orlando Carlos Gloria , Gadelha Telma , Gadelha Mônica R. 
Published: May 2014

SummaryIntroductionRotation thromboelastometry (ROTEM®) can be used for hypercoagulability evaluation. Cushing's syndrome (CS) is associated with hypercoagulability; however, ROTEM® has never been evaluated in this setting.ObjectiveTo evaluate hypercoagulability in CS using ROTEM® and to correlate these parameters with coagulation markers and with the presence of deep vein thrombosis.Design and methodsThirty patients with active CS (26 women) and 30 controls matched for age, sex, body mass index, diabetes mellitus, arterial hypertension, ABO blood group and smoking were included. We measured levels of activated partial thromboplastin time (aPTT), platelets, fibrinogen, D‐dimer, factor VIII (FVIII), von Willebrand factor (vWF) and C‐reactive protein. ROTEM® was used to evaluate the intrinsic (INTEM), extrinsic (EXTEM) and fibrinogen (FIBTEM) pathways. Doppler ultrasonography was performed to search for lower limbs deep vein thrombosis.ResultsINTEM clotting time using ROTEM® was shorter in patients than in controls (P = 0·04). Other ROTEM® parameters were not different. Mean aPTT was shorter in patients than in controls (P = 0·001). The FVIII, vWF and D‐dimer levels were higher in patients than in controls (P = 0·001, 0·001 and 0·02, respectively). Obese CS patients presented higher levels of platelets and alterations in maximum clot formation (MCF), alpha angle and maximum speed of clot formation of INTEM (P = 0·03, 0·02 and 0·02, respectively) and an increase in the MCF of FIBTEM (P = 0·02). No deep vein thrombosis was found.ConclusionsAlthough FVIII and vWF were abnormal in CS patients, only the initiation clot formation was different in the ROTEM® methodology and no deep vein thrombosis was found.
Echocardiography and Cardiac MRI in Mutation‐Negative Hypertrophic Cardiomyopathy in an Older Patient: A Case Defining the Need for ICD
Authors: Rodriguez Fatima , Degnan Kathleen O. , Seidman Christine E. , Mangion Judy R. 
Published: May 2014

We report the case of a 67‐year‐old man with hypertrophic cardiomyopathy who presented for a second opinion about implantable cardio‐defibrillator (ICD) placement after a witnessed syncopal episode. Despite his older age, being mutation‐negative, and having a maximal septal thickness of 2.2 cm on echocardiography, he demonstrated rapid progression of myocardial fibrosis on cardiac MRI, correlating to ventricular tachyarrhythmias and syncope. We review the role of echocardiography and cardiac MRI in optimizing medical care for such patients who may not otherwise meet criteria for an ICD placement or further interventions.
Assessment of the Helical Ventricular Myocardial Band Using Standard Echocardiography
Authors: Hayabuchi Yasunobu , Sakata Miho , Kagami Shoji 
Published: May 2014

BackgroundThe purpose of this study was to assess the feasibility of morphological and functional evaluation of the helical ventricular myocardial band using standard echocardiographic images.MethodsEchocardiographic data were obtained from 132 normal children. We attempted to identify the echogenic bright line serving as the boundary between the ascending and descending segments in the ventricular septum, and between the left and ascending segments in the left ventricular inferior wall in the helical myocardial band model proposed by Torrent‐Guasp. Myocardial deformations on both sides of the bright line were compared using speckle tracking echocardiography.ResultsThe bright line separating the ascending from descending segment was visible in the mid‐ventricular septum in the four‐chamber view in all subjects. This echogenic boundary was observed obliquely in the parasternal short‐axis view in 116 subjects (87.9%). There was no significant difference in peak longitudinal or circumferential strain between the ascending and descending segments. However, the time from the QRS onset to peak circumferential strain was significantly lower in the descending than ascending segment (394.5 ± 37.0 vs. 432.7 ± 33.1 ms, P < 0.0001), whereas there was no significant difference in the time to peak longitudinal strain (394.4 ± 26.4 vs. 393.2 ± 24.1 ms). The bright line between the left and ascending segment was detected in the short‐axis view from the subcostal region in 86 subjects (65.2%). The time to peak circumferential strain was significantly lower in the left than ascending segment (380.1 ± 32.0 vs. 435.7 ± 37.9 ms, P < 0.0001).ConclusionThere is a helical ventricular myocardial band that can be observed in standard echocardiographic images.
An unfished area enhances a spiny lobster, Panulirus argus, fishery: implications for management and conservation within a Biosphere Reserve in the Mexican Caribbean
Authors: Ley‐Cooper K. , De Lestang S. , Phillips B. F. , Lozano‐Álvarez E. 
Published: May 2014

AbstractThe Caribbean spiny lobster, Panulirus argus, Latreille, is the main source of income for the communities in the Sian Ka'an Biosphere Reserve Mexico. The fishery has recently been certified as sustainable by the Marine Stewardship Council provided that further stock assessment is carried out. A total of 379 lobsters were tagged in an unfished area offshore from the Bahía del Espíritu Santo fishing grounds to assess whether lobsters remained within these areas and were thus fully protected. The lobsters recaptured in the shallow area (5.3%) were sufficient to develop a multistate mark recapture model, which takes into account fishing and natural mortality, tag reporting rate and tag loss. This estimated that between 15 and 20% of all adult lobsters dwelling in the unfished area moved into the fishery and were subjected to exploitation. This study suggests that the offshore unfished area provides protection to the majority of the stock in this area while adding to and maintaining fishing yields within the inshore commercial fishery.
Assessment of a catchmentwide salmon habitat rehabilitation scheme on a drained river system in Northern Ireland
Authors: Kennedy R. J. , Johnston P. , Allen M. 
Published: May 2014

AbstractA catchment‐scale salmon, Salmo salar L., habitat enhancement scheme was developed for the River Main (Northern Ireland) with reference to baseline habitat and electric fishing surveys. In total, 19 separate sites were enhanced using flow deflectors or random boulder addition. Habitat suitability for juvenile salmon increased at enhanced sites following the scheme, and significant changes in underlying physical habitat characteristics (particle size, depth and flow) were detected after the installation of flow deflectors. The overall index of salmon fry recruitment, monitored across the catchment, showed no change between pre‐ and post‐enhancement periods. The mean biomass of salmon evident at individual enhancement sites (5.1 g m−2) was significantly higher than the mean biomass at control sites (1.2 g m−2). Increased densities of >0+ juvenile salmon were associated with enhanced sites relative to controls. Marking studies indicated the potential for long‐range dispersal of juvenile salmon between 0+ (summer) and 1+ (summer) age classes. The potential of the scheme to enhance the local salmon stock was discussed.
The role of social norms and informal sanctions in catch‐and‐release angling
Authors: Stensland S. , Aas Ø. 
Published: May 2014

AbstractThis study focuses on norms and informal sanctions of catch‐and‐release angling and their implications for fishery management. A Web‐based questionnaire of Atlantic salmon, Salmo salar L., anglers in the Lakselva River, Norway, yielded 656 answers (response rate 68 %). Anglers were segmented into four subgroups: catch and release, keeper, something else, trophy angler. In all groups, the reward (positive feeling) was high and punishment was low for releasing a large salmon as expressed by the intensity of self‐sanctions. All groups saw keeping a large salmon mostly as a rewarding experience, although the C&R and trophy segments reported less rewards and more ‘punishment’ for keeping. There is evidence for both a medium strength C&R norm and a weak keep norm in this fishery, receiving different ascriptions between angler groups. The results help understand angler group conflicts and explain how angling behaviour is formed, thereby helping management agencies achieving angler satisfaction.
Changes in floral bouquets from compound‐specific responses to increasing temperatures
Authors: Farré‐Armengol Gerard , Filella Iolanda , Llusià Joan , Niinemets Ülo , Peñuelas Josep 
Published: May 2014

AbstractWe addressed the potential effects of changes in ambient temperature on the profiles of volatile emissions from flowers and tested whether warming could induce significant quantitative and qualitative changes in floral emissions, which would potentially interfere with plant–pollinator chemical communication. We measured the temperature responses of floral emissions of various common species of Mediterranean plants using dynamic headspace sampling and used GC‐MS to identify and quantify the emitted terpenes. Floral emissions increased with temperature to an optimum and thereafter decreased. The responses to temperature modeled here predicted increases in the rates of floral terpene emission of 0.03–1.4‐fold, depending on the species, in response to an increase of 1 °C in the mean global ambient temperature. Under the warmest projections that predict a maximum increase of 5 °C in the mean temperature of Mediterranean climates in the Northern Hemisphere by the end of the century, our models predicted increases in the rates of floral terpene emissions of 0.34–9.1‐fold, depending on the species. The species with the lowest emission rates had the highest relative increases in floral terpene emissions with temperature increases of 1–5 °C. The response of floral emissions to temperature differed among species and among different compounds within the species. Warming not only increased the rates of total emissions, but also changed the ratios among compounds that constituted the floral scents, i.e. increased the signal for pollinators, but also importantly altered the signal fidelity and probability of identification by pollinators, especially for specialists with a strong reliance on species‐specific floral blends.
Natural variation in Miscanthus sinensis seed germination under low temperatures
Authors: Dwiyanti Maria S. , Stewart J. Ryan , Nishiwaki Aya , Yamada Toshihiko 
Published: May 2014

AbstractSpecies within the genus Miscanthus show potential as sustainable bioenergy crops given their low nutrient requirements and high biomass yields. One such species, Miscanthus sinensis, has a wide natural distribution and wide phenotypic variation, including its seed germination characteristics. Such characteristics need to be considered, particularly in ensuring plant establishment in regions with harsh winters. Germination rates were measured for 33 M. sinensis accessions from different latitudinal regions in Japan. Generally, seeds of accessions from regions of higher latitude germinate earlier than those from more southerly regions under both warm (30°C/20°C day/night) and cool temperature (15°C/10°C day/night) treatments. However, accessions that had lighter seeds germinated late regardless of origin. This survey serves as a basis for identifying M. sinensis accessions that are able to germinate early under low‐temperature conditions.
European Society of Endodontology position statement: The use of CBCT in Endodontics
Authors: Patel S. , Durack C. , Abella F. , Roig M. , Shemesh H. , Lambrechts P. , Lemberg K. 
Published: May 2014

AbstractThis Position Statement represents a consensus of an expert committee convened by the European Society of Endodontology (ESE) on the use of Cone Beam Computed Tomography (CBCT). The statement is based on the current scientific evidence, and provides the clinician with evidence‐based criteria on when to use CBCT in Endodontics. Given the dynamic and changing nature of research, development of new devices and clinical practice relating to CBCT, this Position Statement will be updated within 3 years, or before that time should new evidence become available.
American India Pale Ale matrix rich in xanthohumol is potent in suppressing proliferation and elevating apoptosis of human colon cancer cells
Authors: Henley Twila , Reddivari Lavanya , Broeckling Corey D. , Bunning Marisa , Miller Jeff , Avens John S. , Stone Martha , Prenni Jessica E. , Vanamala Jairam 
Published: May 2014

SummaryAmerican India Pale Ales (IPAs) with and without addition of dark/roasted malts (DRM) and dry hopping (DP) were analysed to determine whether these processes will increase total phenolic content (TP), antioxidant capacity (AA) and the levels of bioactive compounds (xanthohumol, XN and isoxanthohumol, IX). In addition, bioactivity of whole beer matrices, that is, the ‘phytochemical team approach,’ was compared to isolated compounds, the ‘silver bullet approach,’ by measuring antiproliferative and pro‐apoptotic properties using HCT 116 human colon cancer cells. DP and addition of DRM elevated the XN, IX, TP and AA. Dark malts reduced losses in XN and TP due to filtration. Xanthohumol content positively correlated with phenolic content (r = 0.88, P = 0.0002), indicating that the processes which increased xanthohumol content also elevated other bioactive compounds in beer. However, whole extract from IPAs were more potent in suppressing proliferation and elevating apoptosis in colon cancer cells compared with xanthohumol alone.
Non‐surgical and supportive periodontal therapy: predictors of compliance
Authors: Delatola Chrysoula , Adonogianaki Evagelia , Ioannidou Effie 
Published: May 2014

AbstractAimTo identify predictors of compliance during non‐surgical and supportive periodontal therapy (SPT).Materials and MethodsIn this retrospective study, demographic, dental, medical data of 427 new patients in a private practice were collected. Data were analysed in statistical models with non‐surgical therapy and SPT compliance used as dependent variables.ResultsOf the 427 patients, 17.3% never agreed to initial therapy, 10.7% never completed therapy and 20.8% completed treatment, but never entered SPT. Of the 218 SPT patients, 56% became non‐attenders after a period of 20 months, 33% were erratic attenders and 10.5% were regular attenders until the end of the observation period (5.5–6.5 years). Patients became erratic attenders after a mean period of regular attendance of 18.1 ± 16.2 months, whereas 49.6% of the patients, who abandoned SPT, were regular attenders until the time they stopped. In a univariate correlation model, periodontal disease severity emerged as a significant predictor of the completion of non‐surgical periodontal therapy (p = 0.01). In a multivariate linear regression model, smoking was negatively associated with SPT compliance (p = 0.047).ConclusionsA low compliance of the population was observed. Smoking and periodontal disease severity represented significant, but modest modifiers of a patient compliance with SPT and initial therapy respectively.