bluuebunny/crossref_metadata_2025_split huggingface dataset:
ATTENDANCE AND IMPLEMENTATION OF STRATEGIES IN A BEHAVIORAL PARENT‐TRAINING PROGRAM: COMPARISONS BETWEEN ENGLISH AND ESPAÑOL PROGRAMS
Authors: Ogg Julia , Shaffer‐Hudkins Emily , Childres Jillian , Feldman Marissa , Agazzi Heather , Armstrong Kathleen 
Published: August 2014

ABSTRACTLow levels of attendance and implementation of strategies in behavioral parent‐training programs may limit their impact. The purpose of this study was to examine attendance and implementation across a behavioral parent‐training program delivered in English and Español. Participants included parents (n = 739) of young children who attended a behavioral parent‐training program. The mean number of sessions attended for the entire sample was 4.46 (SD = 1.66, range = 1–6) of six sessions, and the mean number of strategies implemented was 17.66 (SD = 11.43, range = 0–35) of a possible 35. There were no significant differences across the number of sessions attended among the participants in the English (M = 4.45) and Español versions (M = 4.48) of the course, t(737) = −0.20, p = .85. There also were no significant differences between the English (M = 17.97) and Español (M = 16.87) versions for the number of Tip Trackers completed, t(737) = 1.18, p = .24. Only child diagnosis predicted parent attendance in the English group. Implications for research and practice are discussed.
The Presence of Androgen Receptor Elements Regulates ZEB1 Expression in the Absence of Androgen Receptor
Authors: Mooney Steven M. , Parsana Princy , Hernandez James R. , Liu Xin , Verdone James E. , Torga Gonzalo , Harberg Calvin A. , Pienta Kenneth J. 
Published: August 2014

AbstractZinc finger E‐box binding homeobox 1 (ZEB1) is a transcription factor that plays a central role in the epithelial to mesenchymal transition (EMT) of cancer cell lines. Studies on its regulation have mostly focused on the negative 3'UTR binding of miR200c. Interestingly, it has been previously reported that androgen receptor (AR) regulates ZEB1 expression in breast and prostate cancers. In order to validate this, various ZEB1 promoter deletions were cloned into a luciferase reporter system to elucidate the contribution of two putative androgen response elements (AREs). The in vivo contribution of AR was also assessed in cell lines after R1881 treatment using qPCR with prostate specific antigen (PSA) as the positive control. We discovered that AR upregulates the levels of expression of ZEB1 10‐fold on a luciferase promoter that only contains the distal ARE. However, when the proximal ARE is included, no additional activation is apparent with AR or its hormone independent variant, AR‐V7. Furthermore, we demonstrate here that a promoter construct containing both AREs activates transcription of ZEB1 even in the AR‐null cell lines DU145 and PC3. Incubation of the AR‐positive cell line, LNCaP with R1881, failed to substantially increase the expression levels of ZEB1. Despite the presence of AREs in the promoter region, it appears that ZEB1 expression can be induced even without AR. In addition, the region around the distal ARE is a potent repressor in AR‐null cell lines. J. Cell. Biochem. 116: 115–123, 2015. © 2014 Wiley Periodicals, Inc.
An “Ortho Effect” in Electrophilic Aromatic Nitrations: Theoretical Analysis and Experimental Validation
Authors: Li Hui‐Jing , Wu Yan‐Chao , Dai Jian‐Hong , Song b Yan , Cheng Runjiao , Qiao Yuanyuan 
Published: August 2014

AbstractUsually, a π‐donor substituent acts as an ortho/para directing group in an electrophilic aromatic substitution reaction, and a π‐acceptor substituent acts as a meta directing group. Interestingly, when a π‐acceptor substituent is meta to a π‐donor substituent, certain electrophilic aromatic nitration occurs ortho to the acceptor substituent rather than para. The “ortho effect”, highlighted in various text books, has been tentatively analyzed here based on ab initio calculations. The reliability of the calculations was verified by the corresponding experimental data, including a new‐designed electrophilic aromatic nitration that also gave reasonable product distributions.
PLCβ1a and PLCβ1b Selective Regulation and Cyclin D3 Modulation Reduced by Kinamycin F During K562 Cell Differentiation
Authors: Bavelloni Alberto , Dmitrienko Gary I. , Goodfellow Valerie J. , Ghavami Ahmad , Piazzi Manuela , Blalock William , Chiarini Francesca , Cocco Lucio , Faenza Irene 
Published: August 2014

AbstractHere we report that both PLCβ1a and PLCβ1b are relevant regulators of erythropoiesis in that kinamycin F, a potent inducer of γ‐globin production in K562 cells, caused a selectively reduction of both PLCβ1 isozymes even though the results point out that the effect of the drug is mainly directed toward the expression of the PLCβ1a isoform. We have identified a different role for the two isozymes as regulators of K562 differentiation process induced by kinamycin F. The overexpression of PLCβ1b induced an increase in γ‐globin expression even in the absence of kinamycin F. Moreover during K562 differentiation, cyclin D3 level is regulated by PLCβ1 signaling pathway. Namely the amplification of the expression of the PLCβ1a, but not of PLCβ1b, is able to maintain high levels of expression of cyclin D3 even after treatment with kinamycin F. This could be due to their different distribution in the cell compartments since the amount of PLCβ1b is mainly present in the nucleus in respect to PLCβ1a. Our data indicate that the amplification of PLCβ1a expression, following treatment with kinamycin F, confers a real advantage to K562 cells viability and protects cells themselves from apoptosis. J. Cell. Physiol. 230: 587–594, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company
Inhibition of Metalloproteinase Activity in FANCA Is Linked to Altered Oxygen Metabolism
Authors: Ravera Silvia , Capanni Cristina , Tognotti Danika , Bottega Roberta , Columbaro Marta , Dufour Carlo , Cappelli Enrico , Degan Paolo 
Published: August 2014

AbstractBone marrow (BM) failure, increased risk of myelodysplastic syndrome, acute leukaemia and solid tumors, endocrinopathies and congenital abnormalities are the major clinical problems in Fanconi anemia patients (FA). Chromosome instability and DNA repair defects are the cellular characteristics used for the clinical diagnosis. However, these biological defects are not sufficient to explain all the clinical phenotype of FA patients. The known defects are structural alteration in cell cytoskeleton, altered structural organization for intermediate filaments, nuclear lamina, and mitochondria. These are associated with different expression and/or maturation of the structural proteins vimentin, mitofilin, and lamin A/C suggesting the involvement of metalloproteinases (MPs). Matrix metalloproteinases (MMP) are involved in normal physiological processes such as human skeletal tissue development, maturation, and hematopoietic reconstitution after bone marrow suppression. Current observations upon the eventual role of MPs in FA cells are largely inconclusive. We evaluated the overall MPs activity in FA complementation group A (FANCA) cells by exposing them to the antioxidants N‐acetyl cysteine (NAC) and resveratrol (RV). This work supports the hypothesis that treatment of Fanconi patients with antioxidants may be important in FA therapy. J. Cell. Physiol. 230: 603–609, 2015. © 2014 Wiley Periodicals, Inc., A Wiley Company
Surgical treatment for intrahepatic cholangiocarcinoma in Europe: a single center experience
Authors: Bektas Hüseyin , Yeyrek Cemil , Kleine Moritz , Vondran Florian W. R. , Timrott Kai , Schweitzer Nora , Vogel Arndt , Jäger Mark D. , Schrem Harald , Klempnauer Jürgen , Kousoulas Lampros 
Published: August 2014

Abstract Intrahepatic cholangiocarcinoma is the second most common primary liver tumor. The aim of this study was to analyze retrospectively the outcome of surgical treatment and prognostic factors. Clinical, histopathological and treatment data of 221 patients treated from 1995 to 2010 at our institution were investigated. Univariate and multivariate analysis of the patient's data was performed. Patients after R0 and R1 resection presented an overall survival of 67% and 54.5% after 1 year and 40% and 36.4% after 3 years, respectively. The survival of patients without resection of the tumor was dismal with 26% and 3.4% after 1 and 3 years, respectively. Survival after resection was not statistically different in cases with R0 versus R1 resection (P = 0.639, log rank). Univariate Cox regression revealed that higher T stages are a significant hazard for survival (P = 0.048, hazard ratio (HR): 1.211, 95% confidence interval (CI): 1.002–2.465). Patients with tumor recurrence had a significantly inferior long‐term survival when compared to patients without recurrence (P < 0.001, log rank). Presence of lymph node metastasis (N1) was an independent prognostic factor for survival after resection in risk‐adjusted multivariate Cox regression (P < 0.001, HR: 2.577, 95% CI: 1.742–3.813). Adjuvant chemotherapy did not improve patient survival significantly (P = 0.550, log rank). Surgical resection is still the best treatment option for intrahepatic cholangiocarcinoma regarding the patient's long‐term survival. R0 and R1 resection enable both better survival rates when compared to surgical exploration without resection. T status, N status, and tumor recurrence seem to be the most important prognostic factors after resection.
Nature, the CoAuthor of Its Products? An Analysis of the Recent Controversy Over Rejected AOC Wines in France
Authors: Teil Geneviève 
Published: August 2014

AbstractProducers defending terroir have called for and obtained a reform of the AOC (French GI) regulation which they deem to be incapable of containing “dangerous shifts” in the interpretation of terroir. An analysis of their accusations shows that the intellectual property dimension of AOCs is returning to the forefront of concerns. The “terroir” quality of AOCs is the multifaceted result of a duet between the vintner and his vineyard, allowing greater creativity. The present reform embraces this change by adding to regulations specifying the means, an accreditation more receptive to innovation. However, it runs into difficulties over the assessment of typicity upon which the AOC quality guarantee has to be based. This paper concludes with a discussion of the reasons for these difficulties and suggestions for an assessment better suited to the multifaceted nature of typicity.
Current therapeutic options for Huntington's disease: Good clinical practice versus evidence‐based approaches?
Authors: Killoran Annie , Biglan Kevin M. 
Published: August 2014

ABSTRACTTherapeutic decision‐making in Huntington's disease (HD) is often guided by clinical experience, because of the limited empirical evidence available. The only medication for HD that has met the regulatory hurdle for approval is tetrabenazine, indicated for the treatment of chorea. However, its use has limitations, and in the setting of specific contraindications or comorbidities the treatment of choice for chorea is still the multipurpose antipsychotics. For the management of psychiatric disturbances, selective serotonin reuptake inhibitors (SSRIs) and mood stabilizers are often used, although empirical evidence is lacking. Finally, no known effective treatment is available for cognitive dysfunction in HD. We discuss the limited evidence available and current expert opinion on medical treatment of the dominant motor, psychiatric, and cognitive features of HD. This follows a brief introduction on the general principles of HD management and on evidence‐based medicine in relation to clinical practice. © 2014 International Parkinson and Movement Disorder Society
Molecular mechanism driving retroperitoneal adipocyte hypertrophy and hyperplasia in response to a high‐sugar diet
Authors: de Queiroz Karina Barbosa , Coimbra Roney Santos , Ferreira Amanda Rios , Carneiro Cláudia Martins , Paiva Nívia Carolina Nogueira , Costa Daniela Caldeira , Evangelista Elísio Alberto , Guerra‐Sá Renata 
Published: August 2014

ScopeWe have previously shown an increase in adipocyte size and lipid content in retroperitoneal white adipose tissue (rWAT) induced by an 8‐week high‐sugar diet (HSD). In this study, we assessed the effect of a HSD on the transcriptional activity of adipogenic genes in a time‐course study to provide insight regarding the genetic networks involved in the rWAT response to dietary sugar.Methods and resultsWeaned male Wistar rats were fed a standard chow diet or HSD (68% carbohydrates) for 4, 8 or 12 weeks, and rWAT was removed for histopathology and PCR array (adipogenesis) analyses. The HSD induced adipocyte hypertrophy and hyperplasia in rWAT after 12 weeks of ingestion. Additionally, the HSD altered serum VLDL‐cholesterol, triacylglycerol and glucometabolic parameters. Hierarchical clustering revealed HSD‐induced changes in the expression patterns of the tested gene set. Pathway analysis, which used the enrichment analysis algorithm of the Thompson Reuters MetaCore platform, associated a cluster of differentially expressed genes with canonical pathways related to regulating adipocyte differentiation and proliferation (p‐value < 10−7).ConclusionHSD feeding post‐weaning increased both the adipocyte size and number by simultaneously up‐regulating pro‐adipogenic signals (the PPARγ pathway) and down‐regulating anti‐adipogenic signals (Wnt pathway) in young adults.
Curcumin enhances cell‐surface LDLR level and promotes LDL uptake through downregulation of PCSK9 gene expression in HepG2 cells
Authors: Tai Mi‐Hsueh , Chen Po‐Kong , Chen Pei‐Yi , Wu Ming‐Jiuan , Ho Chi‐Tang , Yen Jui‐Hung 
Published: August 2014

ScopeCurcumin has been demonstrated as having numerous desirable characteristics, such as antioxidant, anti‐inflammatory, and antiatherogenic activities. We report the hypocholesterolemic effect and molecular mechanism of curcumin.Methods and resultsWe found that curcumin enhanced LDL receptor (LDLR) level on the cell surface, as well as LDLR activity; however, LDLR transcription and mRNA stability were not affected. Furthermore, we found that proprotein convertase subtilisin/kexin type 9 (PCSK9) gene was downregulated at the transcriptional level by curcumin, leading to an increase in LDL uptake in HepG2 cells. The curcumin‐responsive element of the PCSK9 promoter, a binding site for hepatocyte nuclear factor 1α (HNF‐1α), was also identified. We demonstrated that curcumin reduced the nuclear abundance of hepatocyte nuclear factor 1α, resulting in its attenuated interaction with the PCSK9 promoter and leading to a downregulation of PCSK9 expression. Finally, we showed that curcumin decreased the statin‐induced PCSK9 expression and potentially synergized with statin administration.ConclusionCurrent results indicate that curcumin suppression of PCSK9 expression is associated with increases in cell‐surface LDLR and LDLR activity in hepatic cells and it acts in a molecular mechanism that is distinct from the statins. Curcumin exhibits hypolipidemic activity and may serve as a useful supplement to statin treatment for hypercholesterolemia.
ADE‐WCS‐FDTD method for general dispersive materials and PML implementation
Authors: Liang Feng , Chen Aobo , Zhao Deshuang , Wang Bing‐Zhong 
Published: August 2014

ABSTRACTAn auxiliary differential equation (ADE) based weakly conditionally stable finite‐difference time‐domain (FDTD) method is presented for analysis of wave propagation in general hybrid dispersive materials. The perfectly matched layer is implemented in this novel scheme. Larger time step can be used and hence higher computational efficiency is obtained in this approach, as compared to conventional ADE‐FDTD method. Two numerical examples are included to verify the performances of the proposed algorithm. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2489–2495, 2014
A V‐band frequency quadrupler using subharmonic injection‐locked oscillator with push–push technique
Authors: Zhang Bo , Chou Min‐Li , Huang Fan‐Hsiu 
Published: August 2014

ABSTRACTA V‐band frequency quadrupler with high output power characteristic has been implemented and fabricated using 0.15 µm GaAs pHEMT technology. This quadrupler circuit is achieved by a second‐order subharmonic injection‐locked oscillator and a push–push frequency doubler as the output buffer. The free‐running oscillation frequency of the core oscillator is around 35 GHz with a tuning range of 3.25 GHz covering from 33.25 to 36.5 GHz. Using push–push circuit to be a frequency doubler under a proper bias condition, an optimized second harmonic signal can be accomplished with high harmonic suppression. The frequency of output signal in the quadrupler can present a wide tuning range from 66.5 to 73 GHz, and the maximum output power is −1.25 dBm with total dc consumption of 56 mW. With injecting a second‐order subharmonic signal into the core oscillator, the circuit exhibits an injection locking with an output locking range of about 1.6 GHz from 69.2 to 70.8 GHz. The output phase noise for 70‐GHz signal can be improved better than −105 dBc/Hz at 1 MHz frequency offset when the injected signal power is higher than 0 dBm. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2473–2480, 2014
Short range continuous wave radar for target detection in various mediums
Authors: Tauqeer Tauseef , Islam Maira , Aziz A. K. 
Published: August 2014

ABSTRACTThis article presents simulation and hardware implementation of a low cost radar that can be used as a speed sensor or a metal detector. The overall hardware costs only U.S. $25 and has maximum free space range of 3.65 m. Its underground range is 4.3 cm under wet soil conditions with free space distance of 50 cm above ground. The proposed model provides a basis for designing a mine detector based on the amplitude of the reflected wave. As the frequency of the wave or the water content of the ground increases, the amplitude of the reflected wave decreases making the detection difficult. A comparison between different attenuations offered to the signal under different soil conditions and different Target's materials is presented. The frequency selected for the design implementation was 10.525 GHz. A speed sensor module, HB100 miniature microwave motion sensor was used to sense the reflected wave and was interfaced with a frequency meter implemented using a microcontroller. The module transmitted a continuous wave with amplitude of 15 dBm. The wave reflected from the target was received by module's receiving antenna. It was amplified using a noninverting amplifier and was converted to pulses using a comparator. These pulses were fed to the in‐house microcontroller‐based frequency meter, and the speed of the target was observed on the LCD interfaced. Complete ground modeling for different water content and free space modeling was also done. The proposed model provides a low cost stand‐alone implementation of the overall radar. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2484–2489, 2014
Ground‐embedded dual‐slot perturbation for switchable circularly polarized microstrip antenna
Authors: Kim Jongmyun , Kim Nam , Pyo Seongmin 
Published: August 2014

ABSTRACTThis article reports a new ground‐embedded dual‐slot perturbation for a reconfigurable circularly polarized microstrip antenna. The perturbation consists of the small inner and the large outer slots with two PIN diodes in one diagonal corner for generating and alternating right‐/left‐handed circular polarization, respectively. The measured results of the implemented antenna which used the ground‐embedded dual slot show an agreement with the simulation and successfully demonstrate circularly‐polarized radiations with good controllability. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2537–2539, 2014
Wideband circularly polarized SIW antenna
Authors: Gao Fei , Zhang Fushun , Lu Lu , Jiao Yong‐Chang 
Published: August 2014

ABSTRACTA broadband right hand circularly polarized antenna based on a substrate integrated waveguide (SIW) structure is proposed and experimentally investigated. A novel feeding transition from stripline to SIW introduces the proximity coupling method in SIW structure for meliorating the operating bandwidth. Multiple circularly polarized modes are generated to improve the axial ratio (AR) bandwidth without sacrificing the self‐consistent electrical shielding property. As a result, it is experimentally proved that an impedance bandwidth of 25.6% and an AR bandwidth of 12% have been obtained in X‐band. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2539–2542, 2014
Enhancement of sensitivity of RF modules for wireless health care and home security systems
Authors: Lin Yo‐Sheng , Liang Hsiao‐Bin , Lin Meng‐Chinh , Wang Chi‐Hsiung 
Published: August 2014

ABSTRACTAn effective way to enhance the sensitivity of an RF module for wireless health care (and home security) products is reported. The RF module (followed by a microcontroller unit) consists of an RF front‐end, an radio frequency integrated circuit (RFIC), and a baseband data recovery circuit (DRC). The RF front‐end comprises a power amplifier (PA) output matching network to enhance the output power of the PA, and a low‐noise amplifier (LNA) input matching network to improve the sensitivity of the LNA. The baseband DRC comprises a multiple feedback low‐pass filter to suppress out‐of‐channel noise/interference, and a comparator for rail‐to‐rail digital data recovery. This in turn results in an enormous enhancement of sensitivity (or operation range) of wireless health care (and home security) products equipped with this RF module. Compared with an RF module without the proposed DRC, a 10 dB improvement in sensitivity (from −106 to −116 dB) is achieved. Furthermore, RF field test of a wireless health care product (both with and without the proposed DRC in its RF module) shows a more than 100% enhancement in the wireless operation range (from 150 m to more than 300 m) and a 10‐dB improvement in adjacent channel selectivity. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2563–2568, 2014
Electromagnetic simulation of VLSI circuits by the modified ADI‐FDTD method
Authors: Hwang Jiunn‐Nan , Chen Fu‐Chiarng 
Published: August 2014

ABSTRACTThe alternating direction implicit (ADI) finite‐difference time‐domain (FDTD) method can be used to simulate very large scale integration (VLSI) circuits efficiently as the time step is not restricted by the Courant–Friedrich–Levy stability condition. When the Berenger's split‐field perfectly matched layer (PML) absorbing boundary condition is used for the ADI‐FDTD method for open region simulation, the PML implementation will make this scheme unstable. In this article, the modified PML conductivity profiles are proposed to improve the stability of this scheme. Numerical simulations of the VLSI interconnect and RF inductor in time domain and frequency domain will be demonstrated to show the efficiency and accuracy of this method. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2530–2534, 2014
Determination of the complex permittivity of microfluids in a microstrip geometry
Authors: Schwartz Joshua D. 
Published: August 2014

ABSTRACTA novel configuration for estimating the broadband permittivity of small fluid volumes is presented using 2‐port S‐parameters. Unlike previous demonstrations in coplanar technology, our proposal places the analyte under a microstrip trace where better field overlap with the fluid improves device sensitivity. Fluid parameter estimates based on simulation are presented. © 2014 Wiley Periodicals, Inc. Microwave Opt Technol Lett 56:2604–2608, 2014