bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic variability, correlation and path analysis study for minerals and fruit quality traits in different horticultural groups of muskmelon (Cucumis melo L.)
Authors: Bhimappa BB , Choudhary H , Behera TK , Sharma VK 
Published: July 2024

This experiment was carried out to estimate the extent of genetic variability and character association among different fruit quality traits and fruit yield in 67 genotypes of muskmelon from 3 horticultural groups. The experimental results exhibited significant differences among the genotypes for all the fruit quality attributes under study. On the basis of yield and fruit quality attributes, 7 superior genotypes viz., DM-162, DM-159, DM-143, DM-145, DM- 31, and DM-56 were identified. Further, high heritability estimates coupled with high genetic gain were observed for all the fruit quality traits under study, which indicated that these traits are under additive gene effects and are more reliable for effective selection. The correlation coefficients (phenotypic and genotypic) among different phytonutrients content along with fruit yield exhibited highly significantly positive association with phosphorus (0.374), potassium (0.451), calcium (0.223), magnesium (0.206) and iron content (0.217). Total soluble solids exhibited significant positive association with vitamin C (0.687), total carotenoids (0.292), zinc (0.252), iron (0.192), manganese (0.146), copper (0.161) and fruit yield per plant (0.156). However, TSS showed significantly negative correlation with acidity (-0.875) and sodium content (-0.177).Path direct positive effect (0.348) on yield and indirect positive effect via total carotenoids (0.031), potassium (0.009), calcium (0.006), magnesium (0.009) and negative indirect effects via acidity (-0.120), vitamin C (-0.077), zinc (-0.075) and copper content (-0.051) and ultimately exhibited significant positive correlation (0.143).
The Role of SGLT2 Inhibitors in Managing Heart Failure with Reduced Ejection Fraction
Authors: Faizul Maraam  , Sarbaz Islam Khattak  , Aazan hahib lodhi  , Suleman Ahmad  , Muhammad ibrahim  , Sadaqat Ullah Rehmat  , Sara Nisar  
Published: July 2024

Introduction: Heart failure with reduced ejection fraction (HFrEF) remains a significant clinical challenge despite advances in therapy. Sodium-glucose cotransporter 2 (SGLT2) inhibitors have emerged as promising adjuncts in HFrEF management, with evidence from clinical trials suggesting improved outcomes. This study aims to evaluate the effectiveness and safety of SGLT2 inhibitors in HFrEF.
Methodology: A prospective, single-center observational study was conducted at Hayatabad Medical Complex, Peshawar, from June 2023 to March 2024. Forty-eight patients with HFrEF were enrolled, and baseline demographic, clinical, and laboratory data were collected. Patients received standard therapy alongside SGLT2 inhibitors. Follow-up assessments were performed over 10 months to evaluate changes in left ventricular ejection fraction (LVEF), symptoms, functional capacity, and adverse events.
Results: Following SGLT2 inhibitor therapy, a significant increase in LVEF (mean increase of 5.2 percentage points) was observed, accompanied by reductions in heart failure symptoms and improvements in functional capacity. Heart failure hospitalization rates decreased by 50%, with a favorable safety profile observed.
Conclusion: This study demonstrates the effectiveness and safety of SGLT2 inhibitors in managing HFrEF. The findings support their integration into clinical practice guidelines and emphasize the need for personalized, multidisciplinary approaches to optimize outcomes in HFrEF patients.
Treatment Success with the Ponseti Technique in Congenital Talipes Equino Varusup to two Years of Age.
Authors: Asghar Khan  , Israr Ul Haq  , Dilawar Khan  , Bahadar Ali Khan  , Sajid Akhtar  
Published: July 2024

Background: Congenital talipes equinovarus (CTEV) is a severe foot birth disorder that may make walking difficult and painful and limit mobility. Seventy-five per cent of clubfoot infants are born in low- and middle-income countries. Clubfoot has long been treated. As orthopaedists gravitated toward surgery to treat clubfoot in neonates, non-operative treatment became less popular.
Objective: The study examined how the Ponseti technique works, how bad the deformity is (as measured by the Pirani score), and how much it costs to treat congenital talipes equino Varus in babies under the age of two. The Ponseti Clinic treated 490 individuals with 456 CTEV-infected foot cases.
Study design: A prospective study
Place of duration of study: department of orthopedic Saidu Teaching Hospital swat between 05 Jan 2017 and 05 jan 2021
Material And Methods: this prospective clinical study was conducted in Swat's Saidu Teaching Hospital between 2017 and 2021. 456 patients were selected using the inclusion and exclusion criteria department of orthopaedic saidu teaching hospital swat concluded this study. The youngsters were 3.20 months old on average, and they needed 6.80 casts to improve. At the final follow-up, 90.20 per cent of patients (score > 24) had positive functional outcomes. The Ponseti method for clubfoot treatment may prove most beneficial regarding both functionality and aesthetics. This approach still remains a safe, simple and costeffective way to deal with clubfoot in places such as Pakistan.
Results: our finding ninety percent of patients had a positive prognosis after starting treatment at 3 months of age, which took about seven casts altogether correct their feet.The research has suggested that the Ponseti method is both cheap and effective treatment for congenital talipes equinovarus in babies under 2 years .

Conclusion: this study shows is that the Ponseti technique is not only fine but economical way to deal with clubfoot in infants under two years of age. The method kept plain and safe while also demonstrating a very high success rate.Now the findings of this particular study suggest that the Ponseti technique provides an excellent option for managing clubfoot in underdeveloped countries, such as Pakistan
Keywords: Congenital talipes equinovarus, Ponseti method, Pirani Score, orthopaedics, treatment, clubfoot.
Surgical Intervention for the Treatment of Multiple Glioblastomas A Retrospective observational study
Authors: Muhammad Shoaib  , Sajid Khan  , Syed Nasir Shah  , Imran Ullah  , Bakth Jamal  
Published: July 2024

Background: This trial tested surgery therapy for numerous glioblastomas. A multi-centre study enlisted 32 multiple GBM cases. The outcomes were overall survival, progression-free survival, time to return, and quality of life. Biopsy, debulking, and excision were performed. Overall survival was 13.5 months, and progression-free survival was 8.5 months. Postoperative quality of life improved considerably. Multiple glioblastomas can be treated safely and effectively with surgery.
Objective: This study aims to evaluate the outcomes of glioblastoma patients' surgical resections.
Study design: A Retrospective observational study.
Place and duration of study: department of Neurosurgery, LRH Peshawar from Between 05-January 2015 and 05-January 2018
Methods: the research was carried out at MTI LRH Peshawar Hospital. To find 30 patients with progressing GB, records for everyone who had a glioblastoma biopsy or had it removed between January 2015 and January 2018 were identified and evaluated retrospectively. The median survival and 90% CI were derived by the Kaplan-Meier method. The multivariate analysis was conducted for age, Karnofsky score, amount of resection, tumour size, and tumour multifocality of survival following the advancement of the disease using the Cox Proportional Risks model.
Results: Patients with advanced illnesses underwent the first known resection. Patients who had not yet had resections had median survival after progression of 10.6 months for them and 4.0 months for them. In multivariable analysis, surgical intervention and KPS 0.70 (HR 0.411) were associated with improved survival after GBM progression. The median overall survival was 13.5 months, with a 90% CI of 8.2 to 18.8 months. The median progression-free survival was 8.5 months, with a 90% CI of 5.3 to 11.7 months. Quality of life scores improved significantly postoperatively.
Conclusions: Operative intervention for progressing Glioblastoma effectively treats the symptoms in the current maximum non-operative treatment, but the survival of the patients is restricted. More research is needed to determine ifsurgical surgery can lengthen post-progressive endurance in people with progressive GB.
Keywords: Surgical Intervention, Treatment, Multiple Glioblastomas
Digitalization of control and supervisory activities as a tool for combating corruption
Authors: Kuryndin Pavel Aleksandrovich 
Published: July 2024

The subject of the study is the process of combating corruption, which, due to its changing forms and methods, should be permanent and comprehensive. Moreover, all levels of society are affected by corruption. Digitalization of administrative procedures makes it possible to increase the efficiency of public administration and ensure transparency of decisions. At the same time, it is necessary to assess how the goals and the reality of their implementation coincide. Russia has adopted yet another anti-corruption plan, which is "reinforced" by the introduction of a new Poseidon system that ensures compliance with anti-corruption requirements by various officials. However, the constant bias towards digitalization of administrative procedures and control and supervisory activities cannot automatically lead to the eradication of corruption. It only creates prerequisites. In addition, policy documents in Russia do not set such goals, including even existing international legal acts. Digitalization has many advantages – it is the ease, simplicity and speed of decisions. In fact, the electronic form of control is convenient: you do not need to wait long, prepare documents, the control body can check everything at once. Also, digitalization has already shown effectiveness in reducing "everyday" corruption. However, there is no detailed statistics on the results of appealing control measures in open data. It is impossible to assess what was appealed, what decisions were made and what problems arose. At the same time, the ubiquitous electronic form will not get rid of negative phenomena – there is no single standard of interaction between an administrative body and a non-governmental entity. Regulatory legal acts do not take into account one important aspect: not all individuals have access to the Internet.
Mosaicism for genome‐wide paternal uniparental disomy with features of multiple imprinting disorders: Diagnostic and management issues
Authors: Inbar‐Feigenberg Michal , Choufani Sanaa , Cytrynbaum Cheryl , Chen Yi‐An , Steele Leslie , Shuman Cheryl , Ray Peter N. , Weksberg Rosanna 
Published: December 2012

AbstractMosaicism for genome‐wide paternal uniparental disomy (UPD) has been reported in only seven live born individuals to date. Clinical presentation includes manifestations of multiple paternal UPD syndromes with high variability, likely due to the variable levels of mosaicism in different somatic tissues. We report an eighth case in a female patient with mosaicism for genome‐wide paternal UPD which highlights the complex clinical presentation. Our patient had features of Beckwith–Wiedemann syndrome (BWS), Angelman syndrome, and congenital hyperinsulinism. The clinical findings included prematurity, organomegaly, hemihyperplasia, developmental delay, benign tumors, and cystic lesions. The diagnosis in our patient was established utilizing microarray‐based genome‐wide DNA methylation analysis performed on leukocyte DNA. Targeted multiplex ligation‐dependent probe amplification (MLPA) analysis of chromosome regions 11p15 and 15q13 confirmed mosaicism for paternal UPD at these genomic regions. This case represents the first report of microarray‐based genome‐wide DNA methylation analysis in the diagnosis of genome‐wide paternal UPD. The application of microarray‐based genome‐wide DNA methylation analysis on selected individuals with complex clinical presentations could be a valuable diagnostic tool to improve the detection rate of mosaic genome‐wide paternal UPD. This approach, which screens many loci simultaneously, is more cost‐effective and less labor‐intensive than performing multiple targeted DNA methylation‐based assays. Identification of individuals with mosaicism for genome‐wide paternal UPD is an important goal as it confers a low recurrence risk for the family and identifies individuals who require surveillance due to increased tumor risk. © 2012 Wiley Periodicals, Inc.
Hyperinsulinemic hypoglycemia of infancy in Sotos syndrome
Authors: Matsuo Terumichi , Ihara Kenji , Ochiai Masayuki , Kinjo Tadamune , Yoshikawa Yoko , Kojima‐Ishii Kanako , Noda Marie , Mizumoto Hiroshi , Misaki Maiko , Minagawa Kyoko , Tominaga Koji , Hara Toshiro 
Published: December 2012

AbstractSotos syndrome (OMIM #117550) is a congenital syndrome characterized by overgrowth with advanced bone age, macrocephaly, and learning difficulties. Endocrine complications of this syndrome have not yet been fully described in previous reports. We here investigated the clinical manifestations of Sotos syndrome in Japanese patients who presented with hyperinsulinemic hypoglycemia of infancy. We recruited patients diagnosed as having Sotos syndrome who presented with the complication of hyperinsulinemia during the neonatal period using a survey of the abstracts of Pediatric Meetings in domestic areas of Japan from 2007 to 2011. As a result, five patients (four females and one male) were recruited to evaluate the clinical presentation of Sotos syndrome by reference to the clinical record of each patient. A 5q35 deletion including the NSD1 gene was detected in all patients. Major anomalies in the central nervous, cardiovascular, and genito‐urinary systems were frequently found. Hypoglycemia occurred between 0.5 and 3 hr after birth and high levels of insulin were initially found within 3 days of birth. The patients were treated with intravenous glucose infusion at a maximum rate of 4.6–11.0 mg/kg/min for 12–49 days. Three of the five patients required nasal tube feeding. One patient received medical treatment with diazoxide. This study shows that patients with Sotos syndrome may present with transient hyperinsulinemic hypoglycemia in the neonatal period. © 2012 Wiley Periodicals, Inc.
A 137‐kb deletion within the Potocki–Shaffer syndrome interval on chromosome 11p11.2 associated with developmental delay and hypotonia
Authors: Montgomery Nathan D. , Turcott Christie M. , Tepperberg James H. , McDonald Marie T. , Aylsworth Arthur S. 
Published: December 2012

AbstractPotocki–Shaffer syndrome (PSS) is a rare disorder caused by haploinsufficiency of genes located on the proximal short arm of chromosome 11 (11p11.2p12). Classic features include biparietal foramina, multiple exostoses, profound hypotonia, dysmorphic features, and developmental delay/intellectual disability. Fewer than 40 individuals with PSS have been reported, with variable clinical presentations due in part to disparity in deletion sizes. We report on a boy who presented for initial evaluation at age 13 months because of a history of developmental delay, hypotonia, subtle dysmorphic features, and neurobehavioral abnormalities. SNP microarray analysis identified a 137 kb deletion at 11p11.2, which maps within the classically defined PSS interval. This deletion results in haploinsufficiency for all or portions of six OMIM genes: SLC35C1, CRY2, MAPK8IP1, PEX16, GYLTL1B, and PHF21A. Recently, translocations interrupting PHF21A have been associated with intellectual disability and craniofacial anomalies similar to those seen in PSS. The identification of this small deletion in a child with developmental delay and hypotonia provides further evidence for the genetic basis of developmental disability and identifies a critical region sufficient to cause hypotonia in this syndrome. Additionally, this case illustrates the utility of high resolution genomic approaches in correlating clinical phenotypes with specific genes in contiguous gene deletion syndromes. © 2012 Wiley Periodicals, Inc.
Cerebral amyloid angiopathy burden associated with leukoaraiosis: A positron emission tomography/magnetic resonance imaging study
Authors: Gurol M. Edip , Viswanathan Anand , Gidicsin Christopher , Hedden Trey , Martinez-Ramirez Sergi , Dumas Andrew , Vashkevich Anastasia , Ayres Alison M. , Auriel Eitan , van Etten Ellis , Becker Alex , Carmasin Jeremy , Schwab Kristin , Rosand Jonathan , Johnson Keith A. , Greenberg Steven M. 
Published: December 2012

ObjectiveWe hypothesized that vascular amyloid contributes to chronic brain ischemia, therefore amyloid burden measured by Pittsburgh compound B retention on positron emission tomography (PiB PET) would correlate with the extent of magnetic resonance imaging (MRI) white matter hyperintensities (WMH; or leukoaraiosis) in patients with high vascular amyloid deposition (cerebral amyloid angiopathy [CAA]) but not in patients with high parenchymal amyloid deposition (Alzheimer disease [AD]; mild cognitive impairment [MCI]) or in healthy elderly (HE) subjects.MethodsForty‐two nondemented CAA patients, 50 HE subjects, and 43 AD/MCI patients had brain MRI and PiB PET. Multivariate linear regression was used to assess the independent association between PiB retention and white matter disease volume, controlling for age, gender, apolipoprotein E genotype, and vascular risk factors within each group.ResultsCAA patients were younger than HE and AD subjects (68 ± 10 vs 73.3 ± 7 and 74 ± 7.4, p < 0.01) but had higher amounts of WMH (median = 21 vs 3.2 and 10.8 ml, respectively, p < 0.05 for both comparisons). Global PiB retention and WMH showed strong correlation (rho = 0.52, p < 0.001) in the CAA group but not in HE or AD. These associations did not change in the multivariate models. Lobar microbleed count, another marker of CAA severity, also remained as an independent predictor of WMH volume.InterpretationOur results indicate that amyloid burden in CAA subjects (with primarily vascular amyloid) but not AD subjects (with primarily parenchymal amyloid) independently correlates with WMH volume. These findings support the idea that vascular amyloid burden directly contributes to chronic cerebral ischemia and highlights the possible utility of amyloid imaging as a marker of CAA severity. Ann Neurol 2013;73:529–536
Associations of autoantibodies, autoimmune risk alleles, and clinical diagnoses from the electronic medical records in rheumatoid arthritis cases and non–rheumatoid arthritis controls
Authors: Liao Katherine P. , Kurreeman Fina , Li Gang , Duclos Grant , Murphy Shawn , Guzman Raul , Cai Tianxi , Gupta Namrata , Gainer Vivian , Schur Peter , Cui Jing , Denny Joshua C. , Szolovits Peter , Churchill Susanne , Kohane Isaac , Karlson Elizabeth W. , Plenge Robert M. 
Published: December 2012

AbstractObjectiveThe significance of non–rheumatoid arthritis (RA) autoantibodies in patients with RA is unclear. The aim of this study was to assess associations of autoantibodies with autoimmune risk alleles and with clinical diagnoses from the electronic medical records (EMRs) among RA cases and non‐RA controls.MethodsData on 1,290 RA cases and 1,236 non‐RA controls of European genetic ancestry were obtained from the EMRs of 2 large academic centers. The levels of anti–citrullinated protein antibodies (ACPAs), antinuclear antibodies (ANAs), anti–tissue transglutaminase antibodies (AGTAs), and anti–thyroid peroxidase (anti‐TPO) antibodies were measured. All subjects were genotyped for autoimmune risk alleles, and the association between number of autoimmune risk alleles present and number of types of autoantibodies present was studied. A phenome‐wide association study (PheWAS) was conducted to study potential associations between autoantibodies and clinical diagnoses among RA cases and non‐RA controls.ResultsThe mean ages were 60.7 years in RA cases and 64.6 years in non‐RA controls. The proportion of female subjects was 79% in each group. The prevalence of ACPAs and ANAs was higher in RA cases compared to controls (each P < 0.0001); there were no differences in the prevalence of anti‐TPO antibodies and AGTAs. Carriage of higher numbers of autoimmune risk alleles was associated with increasing numbers of autoantibody types in RA cases (P = 2.1 × 10−5) and non‐RA controls (P = 5.0 × 10−3). From the PheWAS, the presence of ANAs was significantly associated with a diagnosis of Sjögren's/sicca syndrome in RA cases.ConclusionThe increased frequency of autoantibodies in RA cases and non‐RA controls was associated with the number of autoimmune risk alleles carried by an individual. PheWAS of EMR data, with linkage to laboratory data obtained from blood samples, provide a novel method to test for the clinical significance of biomarkers in disease.
Sclerostin is expressed in articular cartilage but loss or inhibition does not affect cartilage remodeling during aging or following mechanical injury
Authors: Roudier Martine , Li Xiaodong , Niu Qing‐Tian , Pacheco Efrain , Pretorius James K. , Graham Kevin , Yoon Bo‐Rin P. , Gong Jianhua , Warmington Kelly , Ke Hua Z. , Black Roy A. , Hulme Joanne , Babij Philip 
Published: December 2012

AbstractObjectiveSclerostin plays a major role in regulating skeletal bone mass, but its effects in articular cartilage are not known. The purpose of this study was to determine whether genetic loss or pharmacologic inhibition of sclerostin has an impact on knee joint articular cartilage.MethodsExpression of sclerostin was determined in articular cartilage and bone tissue obtained from mice, rats, and human subjects, including patients with knee osteoarthritis (OA). Mice with genetic knockout (KO) of sclerostin and pharmacologic inhibition of sclerostin with a sclerostin‐neutralizing monoclonal antibody (Scl‐Ab) in aged male rats and ovariectomized (OVX) female rats were used to study the effects of sclerostin on pathologic processes in the knee joint. The rat medial meniscus tear (MMT) model of OA was used to investigate the pharmacologic efficacy of systemic Scl‐Ab or intraarticular (IA) delivery of a sclerostin antibody–Fab (Scl‐Fab) fragment.ResultsSclerostin expression was detected in rodent and human articular chondrocytes. No difference was observed in the magnitude or distribution of sclerostin expression between normal and OA cartilage or bone. Sclerostin‐KO mice showed no difference in histopathologic features of the knee joint compared to age‐matched wild‐type mice. Pharmacologic treatment of intact aged male rats or OVX female rats with Scl‐Ab had no effect on morphologic characteristics of the articular cartilage. In the rat MMT model, pharmacologic treatment of animals with either systemic Scl‐Ab or IA injection of Scl‐Fab had no effect on lesion development or severity.ConclusionGenetic absence of sclerostin does not alter the normal development of age‐dependent OA in mice, and pharmacologic inhibition of sclerostin with Scl‐Ab has no impact on articular cartilage remodeling in rats with posttraumatic OA.
President's page
Authors: Sonnenwald Diane H. 
Published: December 2012

AbstractEditor's SummaryClosing her year as ASIS&T president, Diane Sonnenwald looks back with thanks to the many who volunteered time and effort as committee and task force chairs and members. Their accomplishments span promoting the discipline and advocating for information professionals, reaching beyond national boundaries through social media and meetings, and establishing an investment program to enhance finances. Committees also managed the awards process, expanded continuing education offerings and coordinated with ISO and NISO on standards. A name change will be voted on by the membership to recognize the association's international scope. Membership categories are under review, and organizational collaborations and conference partnerships are being examined, all to promote the discipline and the association.