bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dialogic feedback at scale: Recommendations for learning analytics design
Authors: Maheshi Bhagya , Dai Wei , Martinez‐Maldonado Roberto , Tsai Yi‐Shan 
Published: July 2024

AbstractBackgroundFeedback is central to formative assessments but aligns with a one‐way information transmission perspective obstructing students' effective engagement with feedback. Previous research has shown that a responsive, dialogic feedback process that requires educators and students to engage in ongoing conversations can encourage student active engagement in feedback. However, it is challenging with larger student cohorts. Learning Analytics (LA) provides promising ways to facilitate timely feedback at scale by leveraging large datasets generated during students' learning. However, current LA design and implementation tend to treat feedback as a one‐way transmission rather than a two‐way process.ObjectivesThis case study aims to improve LA design and practice to align with dialogic feedback principles by exploring an authentic dialogic feedback practice at scale.MethodsWe explored a dialogic feedback practice of a course having 700 undergraduate students. The case study used quantitative and qualitative analysis methods to investigate what students expect from feedback, how educators respond to students' feedback requests, and how students experience feedback.Results and ConclusionsThe results emphasise the need to focus on cognitive, relational and emotional aspects of the feedback process. In aligning LA with dialogic feedback principles, we propose that LA should promote the following objectives: reflection, adaption, personalisation, emotional management, and scaffolding feedback provision.
Identification and validation of miR‐29b‐3p and LIN7A as important diagnostic markers for bone non‐union by WGCNA
Authors: Jian Guojian , Xie Desheng , Kuang Ximu , Zheng Peihuang , Liu Haoyuan , Dong Xuehong 
Published: July 2024

AbstractBone non‐union is a common fracture complication that can severely impact patient outcomes, yet its mechanism is not fully understood. This study used differential analysis and weighted co‐expression network analysis (WGCNA) to identify susceptibility modules and hub genes associated with fracture healing. Two datasets, GSE125289 and GSE213891, were downloaded from the GEO website, and differentially expressed miRNAs and genes were analysed and used to construct the WGCNA network. Gene ontology (GO) analysis of the differentially expressed genes showed enrichment in cytokine and inflammatory factor secretion, phagocytosis, and trans‐Golgi network regulation pathways. Using bioinformatic site prediction and crossover gene search, miR‐29b‐3p was identified as a regulator of LIN7A expression that may negatively affect fracture healing. Potential miRNA‐mRNA interactions in the bone non‐union mechanism were explored, and miRNA‐29‐3p and LIN7A were identified as biomarkers of skeletal non‐union. The expression of miRNA‐29b‐3p and LIN7A was verified in blood samples from patients with fracture non‐union using qRT‐PCR and ELISA. Overall, this study identified characteristic modules and key genes associated with fracture non‐union and provided insight into its molecular mechanisms. Downregulated miRNA‐29b‐3p was found to downregulate LIN7A protein expression, which may affect the healing process after fracture in patients with bone non‐union. These findings may serve as a prognostic biomarker and potential therapeutic target for bone non‐union.
Hsa‐miR‐134‐5p predicts cardiovascular risk in circulating mononuclear cells and improves angiogenic action of senescent endothelial progenitor cells
Authors: Tien Ting‐Yi , Wu Yih‐Jer , Chang Chiung‐Yin , Hung Chung‐Lieh , Lee Yi‐Nan , Lee Hsin‐I , Chou Yen‐Hung , Lin Chao‐Feng , Lee Chun‐Wei , Su Cheng‐Huang , Yeh Hung‐I 
Published: July 2024

AbstractThis research explores the role of microRNA in senescence of human endothelial progenitor cells (EPCs) induced by replication. Hsa‐miR‐134‐5p was found up‐regulated in senescent EPCs where overexpression improved angiogenic activity. Hsa‐miR‐134‐5p, which targeted transforming growth factor β‐activated kinase 1‐binding protein 1 (TAB1) gene, down‐regulated TAB1 protein, and inhibited phosphorylation of p38 mitogen‐activated protein kinase (p38) in hsa‐miR‐134‐5p‐overexpressed senescent EPCs. Treatment with siRNA specific to TAB1 (TAB1si) down‐regulated TAB1 protein and subsequently inhibited p38 activation in senescent EPCs. Treatment with TAB1si and p38 inhibitor, respectively, showed angiogenic improvement. In parallel, transforming growth factor Beta 1 (TGF‐β1) was down‐regulated in hsa‐miR‐134‐5p‐overexpressed senescent EPCs and addition of TGF‐β1 suppressed the angiogenic improvement. Analysis of peripheral blood mononuclear cells (PBMCs) disclosed expression levels of hsa‐miR‐134‐5p altered in adult life, reaching a peak before 65 years, and then falling in advanced age. Calculation of the Framingham risk score showed the score inversely correlates with the hsa‐miR‐134‐5p expression level. In summary, hsa‐miR‐134‐5p is involved in the regulation of senescence‐related change of angiogenic activity via TAB1‐p38 signalling and via TGF‐β1 reduction. Hsa‐miR‐134‐5p has a potential cellular rejuvenation effect in human senescent EPCs. Detection of human PBMC‐derived hsa‐miR‐134‐5p predicts cardiovascular risk.
Prorocentrum canariense sp. nov., a case of pseudo‐cryptic speciation in the cosmopolitan dinoflagellate P. compressum (Prorocentrales, Dinophyceae)
Authors: Gómez Fernando , Martel Quintana Antera , Rodríguez Coello Eduvigis , Raymond Eugenio , Salas Rafael , McClimon Jillian F. , Gómez Pinchetti Juan Luis 
Published: July 2024

AbstractThe planktonic dinoflagellate Prorocentrum compressum is widespread in warm and temperate seas. A strain identified as P. cf. compressum BEA 0681B isolated from the island of Gran Canaria, NE Atlantic Ocean, showed a divergence in rDNA/ITS phylogenies with respect to P. compressum. The Canarian strain was oval, with an average length‐to‐width ratio of 1.35, smooth thecal surface with less than 150 thecal pores, including oblique pores, sometimes with a bifurcated opening. In contrast, P. compressum was rounder, with a length‐to‐width ratio < 1.2, with reticulate‐foveate ornamentation and 200–300 pores per valve. We propose Prorocentrum canariense sp. nov. These species clustered as the most early‐branching lineage in the clade Prorocentrum sensu stricto. Although this clade mainly contains planktonic species, the closer relatives were the benthic species P. tsawwassenense and P. elegans. Interestingly, P. compressum and P. canariense sp. nov. are widely distributed in temperate and warm seas without an apparent morphological adaptation to planktonic life. The formation of two concentric hyaline mucilaginous walls could contribute to this success. We discuss the use of Prorocentrum bidens to solve the nomenclature issue of P. compressum that was described citing a diatom as basionym.
Modeling the growth behavior of Salmonella spp. in grated carrots inoculated with different inoculum levels stored at various temperatures
Authors: Omac Basri 
Published: July 2024

AbstractThe consumption of fresh and fresh‐cut fruits and vegetables, such as carrots, has increased for the last decades for a healthy life and an adequate diet, but concerns regarding the microbial safety of them have been raised. The present study was conducted to develop predictive models for Salmonella spp. in grated carrots. The results showed that Salmonella spp. did not display growth at 5°C, but it grew in grated carrots at other temperatures (10, 15, 20, 25, and 37°C) for both inoculum levels. Also, the inoculum levels affected the growth of this pathogen in grated carrots when the storage temperatures ranged from 15 to 25°C. The theoretical minimum temperatures calculated using the Huang model were 3.48 and 5.79°C for inoculum levels of 101 and 102 CFU/g, respectively. The primary and secondary models performed well in terms of agreement between experimental and estimated values. Furthermore, compared to the Ratkowsky model, the theoretical minimum temperature was given a more reasonable value using the Huang model. The models developed in the present study will be a useful input for future quantitative microbial risk assessment to appraise the proliferation of Salmonella spp. in grated carrots throughout the production process, storage, and distribution.
A single institutional clinical outcome for stages III and IV ovarian cancer patients treated with dose‐dense TC therapy in the frontline or first platinum‐sensitive relapse setting
Authors: Sueoka Kotaro , Kajimura Takuya , Sakai Takahiro , Tamehisa Tetsuro , Okada Maki , Tamura Isao , Taketani Toshiaki , Sugino Norihiro 
Published: July 2024

AbstractAimDose‐dense paclitaxel /carboplatin (ddTC) therapy was shown to be more effective against ovarian cancer than conventional tri‐weekly TC in the JGOG3016 study. However, two phase III studies performed after JGOG3016 did not show the same positive results. Because we have been using ddTC in the frontline or first platinum‐sensitive relapse of ovarian cancer, we investigated the clinical outcome of the patients treated with ddTC.MethodsWe retrospectively examined the response rate (RR), progression free survival (PFS) and adverse events of the patients who were treated with ddTC for stage III and IV epithelial ovarian, tubal and peritoneal cancer from January 2012 to December 2018.ResultsWe analyzed 50 patients for frontline treatment and 11 patients for first platinum‐sensitive relapse treatment, excluding those receiving maintenance therapy. Among the patients that received frontline ddTC treatment, RR was 82.9% for those in a neo‐adjuvant chemotherapy (NACT) setting and 85.0% for those in an adjuvant setting. The median progression‐free survival (PFS) was 20 months after initial therapy. Among 31 cases that achieved remission by frontline surgery and the following ddTC, 22 had a platinum‐sensitive relapse. RR of 11 patients treated with ddTC therapy alone for the first platinum‐sensitive relapse was 81.8%, and the median PFS of these patients was 22 months after the first recurrence.ConclusionsddTC therapy for advanced ovarian cancer achieved high response rates in all settings (NACT, adjuvant or platinum‐sensitive relapse). ddTC therapy was effective for improving the prognosis of patients with stages III and IV of ovarian cancer.
Performance of novel collagen turnover biomarkers to detect increased liver stiffness in MASLD
Authors: Hegmar Hannes , Wiggers Thomas , Nasr Patrik , Vessby Johan , Kechagias Stergios , Nyhlin Nils , Marschall Hanns‐Ulrich , Borssén Åsa Danielsson , Strandberg Rickard , Karsdal Morten , Leeming Diana Julie , Ekstedt Mattias , Hagström Hannes 
Published: July 2024

AbstractBackgroundCleavage products from collagen formation and degradation hold potential as first‐line biomarkers for the risk of advanced fibrosis in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD). Here, we evaluated the performance of PRO‐C3, PRO‐C6, C4M, PRO‐C18L, and the clinical score ADAPT (age, diabetes, PRO‐C3, and platelet count) to detect patients with an LSM >8 kPa or >12 kPa in comparison to the Fibrosis‐4 Index (FIB‐4).MethodsSerum from patients with MASLD (n = 269) from six Swedish University Hospitals was analyzed using enzyme‐linked immunosorbent assay‐based methods. Liver stiffness measurement (LSM) by vibration‐controlled transient elastography was performed. The area under the curve (AUC), calibration curves, and net benefit analysis were used.ResultsAn LSM >8 kPa was found in 108 (40.1%) patients. PRO‐C3, PRO‐C6, C4M, and PRO‐C18L had AUCs ranging from 0.48 to 0.62. ADAPT had the highest AUC (0.73, 95% confidence interval [CI] = 0.67–0.79) to detect patients >8 kPa, compared to FIB‐4 (0.71, (95%CI = 0.64–0.77, p = 0.35), and had a higher net benefit compared to FIB‐4 from a probability threshold of 15%. FIB‐4 and ADAPT performed equally well to detect patients with an LSM >12 kPa, AUC 0.76 versus 0.76, p = 0.93.ConclusionsADAPT seems to be marginally better than FIB‐4 in identifying patients with an LSM >8 kPa. However, the clinical utility of ADAPT as a first line test is uncertain, especially in low‐risk populations. The overall performance of FIB‐4 was similar to that of ADAPT in detecting patients with an LSM of >12 kPa. Altogether, the results suggest that ADAPT might be useful to detect earlier stages of fibrosis in MASLD, but that FIB‐4 remains a first‐line test for advanced fibrosis.
Assessing the environmental performance of green mortgage‐backed securities
Authors: Devine Avis , McCollum Meagan 
Published: July 2024

AbstractThe green bond market is growing substantially, bringing with it a focus on economic and environmental performance. Yet while extensive work exists examining the former, there is little concrete evidence regarding the efficacy of green bond use‐of‐proceeds. Concurrently, the demand for ESG‐compliant investments provides an opportunity to direct capital toward the rehabilitation of one of the most energy‐intensive asset classes: real estate. One program in this space, the Fannie Mae Green Rewards green bond program, offers incentives to borrowers to increase multifamily building energy and water efficiency. Although all program participants must complete a set of preapproved projects targeting energy and water efficiency within 12 months of loan origination, there exists substantial variation in the realization of postorigination efficiency outcomes, and in the variation between projected and actual efficiency improvements. We find that fixed interest rates and supplemental financing loan structures are associated with postorigination energy efficiency improvements, as are newer, larger, and high‐quality assets. However, the ex ante estimates of efficiency savings provided to prospective investors prove unrelated to the efficiency outcomes. These findings highlight opportunities to improve program transparency and calibration across the green bond universe.
Workplace factors related to health care leader well‐being in rural settings
Authors: Sullivan Erin E. , Stephenson Amber L. , DePuccio Matthew J. , Anderson Benjamin , Auxier Bill , Henderson John , Linzer Mark 
Published: July 2024

AbstractPurposeTo examine which workplace factors contribute to health care leader well‐being in rural settings.MethodsWorking with two rurally focused organizations, we administered a Rural Leader Burnout survey to executive leaders. The survey contained 25 questions; 24 were closed‐item multiple choice and 1 open‐ended question. The survey was based on the Mini Z 10 item burnout survey with 5 additional items for leaders. Logistic regression and qualitative content analysis determined factors associated with job satisfaction, burnout, and intent to leave (ITL).FindingsThere were 288 respondents (response rate 22%). Of 272 with complete data, 61.4% were women and 51.8% had worked > 10 years. About 81% reported job satisfaction, 40.2% were burned out, and 49.8% intended to leave their administrative roles within 2 years. Factors statistically associated with satisfaction were work control (OR = 3.0), values alignment with leadership (OR = 2.1), and trust in organization (OR = 2.0). Work control (OR = 0.3), trust in organization (OR = 0.4), and stress (OR = 4.1) were associated with burnout. Trust in organization (OR = 0.5), feeling valued (OR = 0.6), and stress (OR = 1.8) associated with ITL. Qualitative data revealed three themes relevant to rural leaders: (1) industry challenges, (2) daily operational issues, and (3) difficult relationships.ConclusionsThese exploratory analyses demonstrate practical ways to improve work conditions to mitigate burnout and turnover in rural leaders. Promoting thriving in leaders would be an important step in maintaining the rural health care workforce.
Narcolepsy and rapid eye movement sleep
Authors: Biscarini Francesco , Barateau Lucie , Pizza Fabio , Plazzi Giuseppe , Dauvilliers Yves 
Published: July 2024

SummarySince the first description of narcolepsy at the end of the 19th Century, great progress has been made. The disease is nowadays distinguished as narcolepsy type 1 and type 2. In the 1960s, the discovery of rapid eye movement sleep at sleep onset led to improved understanding of core sleep‐related disease symptoms of the disease (excessive daytime sleepiness with early occurrence of rapid eye movement sleep, sleep‐related hallucinations, sleep paralysis, rapid eye movement parasomnia), as possible dysregulation of rapid eye movement sleep, and cataplexy resembling an intrusion of rapid eye movement atonia during wake. The relevance of non‐sleep‐related symptoms, such as obesity, precocious puberty, psychiatric and cardiovascular morbidities, has subsequently been recognized. The diagnostic tools have been improved, but sleep‐onset rapid eye movement periods on polysomnography and Multiple Sleep Latency Test remain key criteria. The pathogenic mechanisms of narcolepsy type 1 have been partly elucidated after the discovery of strong HLA class II association and orexin/hypocretin deficiency, a neurotransmitter that is involved in altered rapid eye movement sleep regulation. Conversely, the causes of narcolepsy type 2, where cataplexy and orexin deficiency are absent, remain unknown. Symptomatic medications to treat patients with narcolepsy have been developed, and management has been codified with guidelines, until the recent promising orexin‐receptor agonists. The present review retraces the steps of the research on narcolepsy that linked the features of the disease with rapid eye movement sleep abnormality, and those that do not appear associated with rapid eye movement sleep.
Efficacy and safety of Vibegron for the treatment of residual overactive bladder symptoms after laser vaporization of the prostate: A single‐center prospective randomized controlled trial (VAPOR TRIAL)
Authors: Seki Narihito , Masaoka Hiroyuki , Song Yoohyun , Dejima Takashi , Sato Yoshiaki , Maeda Shotaro 
Published: July 2024

AbstractObjectivesThis study aimed to evaluate the efficacy and safety of Vibegron for the treatment of residual overactive bladder (OAB) symptoms after laser vaporization of the prostate (photo‐selective vaporization of the prostate, contact laser vaporization of the prostate, and thulium laser vaporization).MethodsThis randomized, open‐label, parallel‐group, single‐center superiority trial with a 12‐week observation (jRCTs071190040) enrolled male patients with OAB aged 40 years or older who had undergone laser vaporization of the prostate for not less than 12 weeks and not more than 1 year earlier. Patients were allocated to receive Vibegron 50 mg once daily or follow‐up without treatment for 12 weeks.ResultsForty‐seven patients were enrolled between January 2020 and March 2023. The median age (interquartile range) was 75.5 (72.5–78.5) years for the Vibegron group and 76.5 (71.0–81.0) years for the control group. The intergroup difference in the mean change (95% confidence interval) in the 24‐hour urinary frequency at 12 weeks after randomization was −3.66 (−4.99, −2.33), with a significant decrease for the Vibegron group. The Overactive Bladder Symptom Score, International Prostate Symptom Score, IPSS storage score, and Overactive Bladder Questionnaire score significantly improved for the Vibegron group. Voided volume per micturition also increased for the Vibegron group.ConclusionsThe administration of 50 mg of Vibegron once daily for 12 weeks showed significant improvement compared with follow‐up without treatment in bladder storage (OAB) symptoms after laser vaporization of the prostate for symptomatic benign prostatic hyperplasia.
African philosophy cannot be a thing
Authors: Odeyemi Idowu 
Published: July 2024

AbstractThis essay unpacks several arguments about the metaphilosophic nature of African philosophy and charts a way through the problems these arguments encounter. It argues that we must be careful in our attempt to define African philosophy conceptually. Because to define it is to limit it—and to limit it is to conserve it and lead it to a cesspool. It also argues that finding a single meaning for African philosophy is not a rich endeavour, because, just like Western philosophy, African philosophy should not be a thing but be a vast array of things. The argument, one hopes, is taken as a normative rather than a merely prescriptive enterprise.
Predicting symptom severity in PSTVd‐infected tomato plants using the PSTVd genome sequence
Authors: Sun Jianqiang , Matsushita Yosuke 
Published: July 2024

AbstractViroids, one of the smallest known infectious agents, induce symptoms of varying severity, ranging from latent to severe, based on the combination of viroid isolates and host plant species. Because viroids are transmissible between plant species, asymptomatic viroid‐infected plants may serve as latent sources of infection for other species that could exhibit severe symptoms, occasionally leading to agricultural and economic losses. Therefore, predicting the symptoms induced by viroids in host plants without biological experiments could remarkably enhance control measures against viroid damage. Here, we developed an algorithm using unsupervised machine learning to predict the severity of disease symptoms caused by viroids (e.g., potato spindle tuber viroid; PSTVd) in host plants (e.g., tomato). This algorithm, mimicking the RNA silencing mechanism thought to be linked to viroid pathogenicity, requires only the genome sequences of the viroids and host plants. It involves three steps: alignment of synthetic short sequences of the viroids to the host plant genome, calculation of the alignment coverage, and clustering of the viroids based on coverage using UMAP and DBSCAN. Validation through inoculation experiments confirmed the effectiveness of the algorithm in predicting the severity of disease symptoms induced by viroids. As the algorithm only requires the genome sequence data, it may be applied to any viroid and plant combination. These findings underscore a correlation between viroid pathogenicity and the genome sequences of viroid isolates and host plants, potentially aiding in the prevention of viroid outbreaks and the breeding of viroid‐resistant crops.