bluuebunny/crossref_metadata_2025_split huggingface dataset:
Global adaptive output stabilization of uncertain nonlinear systems with polynomial output depending growth rate
Authors: Benabdallah Abdallah , Ayadi Habib , Mabrouk Mohamed 
Published: May 2013

SUMMARYThis paper investigates the problem of global output stabilization for a family of uncertain nonlinear systems, which are dominated by a triangular‐type condition. The distinguishing feature of such a class of systems is the presence of unmeasured states growth with growth rate polynomial of output‐input multiplying an unknown constant. We show by an example that the power of the input in the growth rate seems to be optimal.Copyright © 2013 John Wiley & Sons, Ltd.
Noncompaction in the fetus and neonate: An autopsy study
Authors: Ursell Philip C. 
Published: May 2013

AbstractNoncompaction refers to an uncommon structural abnormality of the heart's ventricular myocardium characterized by an abnormally thick layer of left ventricular trabeculations, as well as hypoplastic papillary muscles. The condition is associated with a variable clinical phenotype including heart failure, thromboembolism, and sudden death. In this retrospective study of fetal and neonatal autopsy hearts with noncompaction, clinical profiles were correlated with gross and histologic findings and compared with a set of age‐matched controls. Pathologic criteria for noncompaction included hypoplastic left ventricular papillary muscles, abnormal trabecular architecture and greater than 50% penetration of the left ventricular wall thickness by intertrabecular recesses. Among eight fetuses and full‐term neonates with pathologic features of noncompaction, all had evidence of severe heart failure, including four with complete heart block and two others with bradycardia. None experienced sudden death. Seven of eight hearts had associated heart malformations—four with left atrial isomerism, two with aortic and/or pulmonary valve dysplasia consistent with stenosis and, one with atrial septal defect. One heart with noncompaction had no associated malformations. With characteristic excessive trabeculation in the left ventricle, noncompaction also included biventricular endocardial fibroelastosis that denoted right ventricular involvement in all hearts. Thus, (1) among autopsied fetuses and neonates with noncompaction, heart failure including heart block is a common cause of death, (2) noncompaction is often associated with various cardiovascular malformations, but even in isolation it can be the basis for severe cardiac failure, and (3) biventricular endocardial fibroelastosis in noncompaction suggests a global pathologic process. © 2013 Wiley Periodicals, Inc.
Asymmetric Carbon–Carbon Bond Formation under Continuous‐Flow Conditions with Chiral Heterogeneous Catalysts
Authors: Tsubogo Tetsu , Ishiwata Takanori , Kobayashi Shū 
Published: May 2013

AbstractCatalytic asymmetric carbon–carbon bond‐forming reactions provide one of the most efficient ways to synthesize optically active compounds, and, accordingly, many chiral catalysts for these reactions have been developed in the past two decades. However, the efficiency of the catalysts in terms of turnover number (TON) is often lower than that of some other reactions, such as asymmetric hydrogenation, and this has been one of the obstacles for industrial applications. Although there are some difficulties in increasing the efficiency, the issues might be solved by using continuous flow in the presence of chiral heterogeneous catalysts. Indeed, continuous‐flow systems have several advantages over conventional batch systems. Here we summarize the recent progress in asymmetric CC bond‐forming reactions under continuous‐flow conditions with chiral heterogeneous catalysts.
Stability of a Damped Hyperbolic Timoshenko System Coupled with a Heat Equation
Authors: Yang Li‐Juan , Wang Jun‐Min 
Published: May 2013

AbstractWe consider a one‐dimensional damped hyperbolic Timoshenko beam that is coupled with a heat equation. When its wave speeds are different, it is known that the Timoshenko beam that is coupled with a heat equation, under Cattaneo's law, does not have exponential stability. With two internal dampings being introduced, in this paper, we show that the system under Cattaneo's law is exponentially stable. We also show the exponential stability when the system is considered under Fourier's law.
Adaptive Stabilization for a Class of Stochastic Nonlinear Systems with Prandtl‐Ishlinskii Hysteresis
Authors: Ma Yike , Ji Haibo , Liu Wei 
Published: May 2013

AbstractThis paper deals with a class of stochastic nonlinear systems with unknown hysteresis. A stochastic Lyapunov method is applied for systems in strict‐feedback form driven by unknown Prandtl‐Ishlinskii hysteresis and Wiener noises of unknown covariance. An adaptive controller is obtained which guarantees the global asymptotic stabilization in probability. Simulation results are provided to illustrate the effectiveness of the proposed approach.
Recombinant l‐phenylalanine ammonia lyase from Rhodosporidium toruloides as a potential anticancer agent
Authors: Babich Olga O. , Pokrovsky Vadim S. , Anisimova Natalia Yu. , Sokolov Nikolai N. , Prosekov Alexander Yu. 
Published: May 2013

AbstractThe recombinant producer strain expressing Rhodosporidium toruloides l‐phenylalanine ammonia lyase (PAL) has been obtained, and a purification procedure of PAL has been developed. The purified enzyme, PAL, has the following biochemical and catalytic characteristics: Km for l‐Phe of 0.49 mM, pH optimum at 8.5, and temperature optimum at 50°C. PAL exhibited a significant cytotoxic effect toward the following cell lines: MCF7 (IC50 = 1.97 U/mL), DU145 (IC50 = 7.3 U/mL), which are comparable with E. coli l‐asparaginase type‐II cytotoxicity in vitro. Administration of PAL (200–400 U/kg) to L5178y‐bearing mice for five times (a total dose of 1000–2000 U/kg) was well tolerated and showed the increase of life span (ILS) = 12–16%, P < 0.05. Data obtained suggest that PAL from R. toruloides has a potential for cancer treatment.
Schedule‐dependent therapeutic efficacy of L19mTNF‐α and melphalan combined with gemcitabine
Authors: Mortara Lorenzo , Orecchia Paola , Castellani Patrizia , Borsi Laura , Carnemolla Barbara , Balza Enrica 
Published: May 2013

AbstractL19‐tumor necrosis factor alpha (L19mTNF‐α; L), a fusion protein consisting of mouse TNFα and the human antibody fragment L19 directed to the extra domain‐B (ED‐B) of fibronectin, is able to selectively target tumor vasculature and to exert a long‐lasting therapeutic activity in combination with melphalan (M) in syngeneic mouse tumor models. We have studied the antitumor activity of single L19mTNF‐α treatment in combination with melphalan and gemcitabine (G) using different administration protocols in two histologically different murine tumor models: WEHI‐164 fibrosarcoma and K7M2 osteosarcoma. All responding mice showed significant reduction in myeloid‐derived suppressor cells (MDSCs) and an increase in CD4+ and CD8+ T cells in the tumor infiltrates, as well as significant reduction in regulatory T cells (Treg) at the level of draining lymph nodes. What is important is that all cured mice rejected tumor challenge up to 1 year after therapy. Targeted delivery of L19mTNF‐α synergistically increases the antitumor activity of melphalan and gemcitabine, but optimal administration schedules are required. This study provides information for designing clinical studies using L19mTNF‐α in combination with chemotherapeutic drugs.
Rights, Responsibilities and Pragmatic Practice: Family Participation in Case Reviews
Authors: Morris Kate , Brandon Marian , Tudor Paul 
Published: May 2013

This article considers the experiences of families and professionals in case reviews where a child has died/suffered serious injury as a result or abuse or neglect. There is an expectation in the four UK nations that families will be included in such case reviews. The article draws on a study of policies and practices, and family accounts of involvement. An overview of UK policies and practices is described, and the broader questions that emerge for participatory practices identified. Family experiences in this complex area of practice are considered, and recommendations made for practice. The uneven picture of family involvement is argued to reflect uncertainty about the purpose, value and role of family involvement. Concerns are raised about the unresolved dilemmas arising from family involvement and the potential for practice to be unhelpful if not carefully examined. Copyright © 2013 John Wiley & Sons, Ltd.‘An overview of UK policies and practices is described, and the broader questions that emerge for participatory practices identified’Key Practitioner Messages:

Family involvement in reviews is an expectation across the UK nations, but with limited practice guidance.
Family perspectives add invaluable insights and support learning for future protective services.
Professionals have common drivers for family involvement in reviews, but few policies articulate the purpose of participation.
Family involvement raises difficult questions for participatory practices.
Without further clarity and adoption of principles for practice, dilemmas will remain whatever review models are adopted.
Triangulating consumers' perceptions of payment systems by using social representations theory: A multi‐method approach
Authors: Penz Elfriede , Sinkovics Rudolf R. 
Published: May 2013

ABSTRACTSocial systems play a pivotal role in shaping customers' views, the adoption process and subsequent product diffusion for novel products. Perceptions of Austrian consumers regarding payment systems were assessed in a cross‐sectional analysis applying social representations theory. Social representations help to unravel the sources of individuals' attitudinal or perceptual similarities and differences, which often stem from inter‐group differences. In short, they are useful for the investigation of ‘deeper structure’ aspects of consumer behaviour, as has been shown in previous studies. This may be seen as a further step forward for marketing research, which operates largely on social phenomena.This study addresses the shortage of non‐cognitive‐based research in marketing by offering a methodological approach that uses triangulation on the basis of associative answers from social groups. A four‐step analytic design revealed that consumer groups transpose the abstract concept of payment systems into tangible objects and processes in a similar way; however, their social background impacted which value was attached to established as well as new means of payment. Cash is still seen as the prototypical form of payment; newer forms, such as credit cards or ATM cards, appear already in the periphery of representations, urgently needing well‐concerted marketing efforts to become recognized as substitutes for cash. From a managerial view, the research employs social phenomena as a basis for segmenting natural rather than nominal groups in order to better serve consumers' needs in an increasingly connected social reality. Copyright © 2013 John Wiley & Sons, Ltd.
Separation, Hydrodynamics, and Joule Heating Effects in Continuous Annular Electrochromatography
Authors: Laskowski R. , Bart H.‐J. 
Published: May 2013

AbstractFirst experimental results of the transfer from an analytical batch electrochromatography to a continuous annular electrochromatographic process are presented. In order to study the electrochromatographic effects, hydrodynamics and functionality tests were investigated in a planar reference system. As stationary phase inside the annular gap, an inorganic C8 reverse‐phase monolith prepared by an in situ sol‐gel process was implemented. The generation of Joule heating during the process was determined by a contact‐free thermal camera system. The volumetric flow rates of the electrolyte were detected by a gravimetric contact‐free measurement method. Finally, a mixture of neutral test substances was used to evaluate the continuous separation efficiency and to fractionate the single substances under process‐like conditions. The separation results were detected by an inline UV‐Vis detection cell and the analysis of the single fractions was performed by an analytical electrochromatograph. The results indicate uniform electroosmotic flow as well as successful separation and fractioning of a neutral test mixture.
State of the Art of Mini/Micro Jet Reactors
Authors: Santos R. J. , Sultan M. A. 
Published: May 2013

AbstractFor over three decades, opposed‐jets reactors have been applied particularly for fast complex chemical reactions where mixing affects the final product distribution. The first opposed‐jets reactors, i.e., confined impinging jets (CIJ), had cylindrical geometries. With the advent of microreactors, a new type of prismatic opposed‐jets reactors has been introduced, the so‐called T‐jets reactors. The state of the art of the know‐how on mixing in CIJ reactors as well as the current state of the art of T‐jets reactors is described. T‐jets and CIJ are generally small‐scale devices, ensuring that these units can mix fluids within very short mixing times on the order of milliseconds. The small scale has the disadvantage of compromising the reactors' throughput. This fact can prevent the dissemination of this type of mixers to applications where conventional reactors, such as stirred tanks, are used. Attention is paid to the issue on how to scale up opposed‐jets reactors without compromising mixing times. A short analysis of the main research questions to be answered in this field is made.
Separation of Selected Imidazole Enantiomers Using Dual Cyclodextrin System in Micellar Electrokinetic Chromatography
Authors: Wan Ibrahim Wan Aini , Abd Wahib Siti Munirah , Hermawan Dadan , Sanagi Mohd Marsin , Aboul‐Enein Hassan Y. 
Published: May 2013

ABSTRACTCyclodextrin‐modified micellar electrokinetic chromatography (CD‐MEKC) method was developed for simultaneous enantioseparation of three imidazole drugs namely tioconazole, isoconazole and fenticonazole. Three easily available and inexpensive cyclodextrins namely 2‐hydroxypropyl‐β‐cyclodextrin (HP‐β‐CD), 2‐hydroxypropyl‐γ‐cyclodextrin (HP‐γ‐CD) and heptakis(2,6‐di‐O‐methyl)‐β‐cyclodextrin (DM‐β‐CD) were evaluated to discriminate the six stereoisomers of the drugs. However, none of the three CDs gave a complete enantioseparation of the drugs. Effective enantioseparation of tioconazole, isoconazole and fenticonazole was achieved using a combination of 35 mM HP‐γ‐CD and 10 mM DM‐β‐CD as chiral selectors. The best separation using both HP‐γ‐CD and DM‐β‐CD (35 mM:10 mM) as chiral selectors were accomplished in background electrolyte (BGE) containing 35 mM phosphate buffer (pH 7.0), 50 mM sodium dodecyl sulfate (SDS) and 15% (v/v) acetonitrile at 27 kV and 30 °C with all peaks resolved in less than 15 min with resolutions, Rs 1.90‐27.22 and peak efficiencies, N > 180 000. The developed method was linear over the concentration range of 25–200 mg l‐1 (r2 > 0.998) and the detection limits (S/N = 3) of the three imidazole drugs were found to be 2.7‐7.7 mg l‐1. The CD‐MEKC method was successfully applied to the determination of the three imidazole drugs in spiked human urine sample and commercial cream formulation of tioconazole and isoconazole with good recovery (93.6‐106.2%) and good RSDs ranging from 2.30‐6.8%. Chirality 25:328–335, 2013. © 2013 Wiley Periodicals, Inc.
Enantioselective Degradation of the Chiral Fungicides Metalaxyl and Furalaxyl by Brevibacillus brevis
Authors: Sulimma Lutz , Bullach Anke , Kusari Souvik , Lamshöft Marc , Zühlke Sebastian , Spiteller Michael 
Published: May 2013

ABSTRACTFor almost four decades, the chiral fungicides metalaxyl and furalaxyl have been in use in plant protection on a global scale. Both substances are distributed as racemic mixtures, yet the desirable interference in nucleic acid synthesis of harmful fungi only occurs by the (‐)‐R‐enantiomer. As enantioselective degradation in Scheyern (Germany) and Yaoundé (Cameroon) soils has been documented, the influence of 50 isolated microorganisms on the R/S ratio was investigated. A high‐pressure liquid chromatography method with a chiral column to separate enantiomers of metalaxyl and furalaxyl, and subsequent detection by tandem mass spectrometry, was employed. Only one of these microorganisms, a strain of Brevibacillus brevis, showed an enantioselective degradation pattern in liquid culture; the respective (‐)‐R‐enantiomers were preferably degraded. Moreover, (‐)‐R‐furalaxyl was degraded faster in cultures supplemented simultaneously with both fungicides of the same concentration. Chirality 25:336–340, 2013. © 2013 Wiley‐Liss Inc. Chirality 00:000‐000:, 2013. © 2013 Wiley Periodicals, Inc.
Online Analysis of Enzymatic Polycondensation Reactions in Bubble Column Reactors by Means of ATR‐FTIR Spectroscopy
Authors: Gebhard Jakob , Sellin Daniel , Hilterhaus Lutz , Liese Andreas 
Published: May 2013

AbstractDie enzymkatalysierte Polykondensation von 1,3‐Propandiol und 9‐((Z)‐Non‐3‐enyl)‐10‐octylnonadecandisäure führte in einem Blasensäulenreaktor zu einem Umsatz von 94 %. Auf Basis von kontinuierlich aufgenommenen Absorptionsspektren durch ein Fourier‐Transformations‐Infrarot‐Spektrometer mit einer abgeschwächten Totalreflexions‐Sonde im mittleren Infrarot‐Bereich wurde ein chemometrisches Modell zur Bestimmung des Umsatzes sowie des Molekulargewichtes erstellt. In einer internen Validierung zeigten beide Modelle eine gute Genauigkeit mit einem mittleren Fehler der Kreuzvalidierung von 2,14 % für den Umsatz und 319 g mol–1 für das Molekulargewicht.
Optimisation of photo‐Fenton‐like degradation of aqueous polyacrylic acid using Box‐Behnken experimental design
Authors: Ghafoori Samira , Mehrvar Mehrab , Chan Philip 
Published: May 2013

AbstractThe effectiveness of photo‐Fenton‐like process to degrade aqueous polyacrylic acid (PAA) is investigated in a batch recirculation system using two photoreactors in series. The response surface methodology (RSM) using the Box–Behnken experimental design combined with quadratic programming is employed for the experimental design, the statistical analysis and the optimisation. The effects of the initial concentration of PAA, the initial concentration of H2O2:Fe3+, pH and the recirculation rate on the percent removal of total organic carbon (TOC)and the ‘pseudo’‐second order rate constant as the process responses are studied. The statistical analysis of the results indicates a satisfactory prediction of the system behaviour by the developed quadratic models. Optimum operating conditions to maximise the percent TOC removal are also determined.
Sol‐gel Synthesis and Electrochemical Performance of Li4−xMgxTi5−xZrxO12 Anode Material for Lithium‐ion Batteries
Authors: Qiu Caixia , Yuan Zhongzhi , Liu Ling , Cheng Sijie , Liu Jincheng 
Published: May 2013

AbstractThe anode materials Li4−xMgxTi5−xZrxO12 (x=0, 0.05, 0.1) were successfully synthesized by sol‐gel method using Ti(OC4H9)4, CH3COOLi·2H2O, MgCl2·6H2O and Zr(NO3)3·6H2O as raw materials. The crystalline structure, morphology and electrochemical properties of the as‐prepared materials were characterized by XRD, SEM, cyclic voltammograms (CV), electrochemical impedance spectroscopy (EIS) and charge‐discharge cycling tests. The results show that the lattice parameters of the Mg‐Zr doped samples are slightly larger than that of the pure Li4Ti5O12, and Mg‐Zr doping does not change the basic Li4Ti5O12 structure. The rate capability of Li4−xMgxTi5−xZrxO12 (x=0.05, 0.1) electrodes is significantly improved due to the expansile Li+ diffusion channel and reduced charge transfer resistance. In this study, Li3.95Mg0.05Ti4.95Zr0.05O12 represented a relatively good rate capability and cycling stability, after 400 cycles at 10 C, the discharge capacity retained as 134.74 mAh·g−1 with capacity retention close to 100%. The excellent rate capability and good cycling performance make Li3.95Mg0.05Ti4.95Zr0.05O12 a promising anode material in lithium‐ion batteries.
A Review on State‐of‐the‐Art Data Regarding Safe Early Discharge Following Admission for Pulmonary Embolism: What Do We Know?
Authors: Barra Sérgio Nuno Craveiro , Paiva Luís , Providência Rui , Fernandes Andreia , Marques António Leitão 
Published: May 2013

AbstractBackgroundAlthough most patients with acute pulmonary embolism (PE) remain hospitalized during initial therapy, some may be suitable for partial or complete outpatient management, which may have a significant impact on healthcare costs.HypothesisThis article reviews the state‐of‐the‐art data regarding recognition of very‐low‐risk PE patients who are potentially eligible for outpatient treatment, along with the safety, management, and cost‐effectiveness of this strategy. We propose an algorithm based on collected data that may be useful/practical for identifying patients truly eligible for early discharge.MethodsComprehensive review of scientific data collected from the MEDLINE and Cochrane databases. Studies selected based on potential scientific interest. Qualitative information extracted regarding feasibility, safety, and cost‐effectiveness of outpatient treatment, postdischarge management, and selection of truly low‐risk patients.ResultsEarly discharge of low‐risk patients seems feasible, safe, and particularly cost‐effective. Several risk scores have been developed and/or tested as prediction tools for the recognition of low‐risk individuals: the Pulmonary Embolism Severity Index (PESI), simplified PESI, Hestia criteria, Geneva score, the Low‐Risk Pulmonary Embolism Decision rule, and the Global Registry of Acute Cardiac Events, among others. PESI is the most well‐validated model, offering the safest approach at the current time, especially when combined with additional parameters such as troponin I, N‐terminal prohormone of brain natriuretic peptide, and echocardiographic markers of right‐ventricular dysfunction.ConclusionsRecognition of truly low‐risk patients entitled to early hospital discharge and outpatient treatment is possible with current risk‐stratification schemes along with selected prognostic parameters, and it may have a colossal impact on healthcare costs.
Combined Delivery of Bone Marrow‐Derived Mononuclear Cells in Chronic Ischemic Heart Disease: Rationale and Study Design
Authors: Sürder Daniel , Radrizzani Marina , Turchetto Lucia , Cicero Viviana Lo , Soncin Sabrina , Muzzarelli Stefano , Auricchio Angelo , Moccetti Tiziano 
Published: May 2013

AbstractBackgroundTreatment with bone marrow‐derived mononuclear cells (BM‐MNC) may improve left ventricular (LV) function in patients with chronic ischemic heart disease (IHD). Delivery method of the cell product may be crucial for efficacy.HypothesisWe aimed to demonstrate that the combination of intramyocardial and intracoronary injection of BM‐MNC is safe and improves LV function in patients with chronic IHD.MethodsAfter a safety/feasibility phase of 10 patients, 54 patients will be randomly assigned in a 1:1:1 pattern to 1 control and 2 BM‐MNC treatment groups. The control group will be treated with state‐of‐the‐art medical management. The treatment groups will receive either exclusively intramyocardial injection or a combination of intramyocardial and intracoronary injection of autologous BM‐MNC. Left ventricular function as well as scar size, transmural extension, and regional wall‐motion score will be assessed by cardiac magnetic resonance imaging studies at baseline and after 6 months. The primary endpoint is the change in global LV ejection fraction by cardiac magnetic resonance from 6 months to baseline.ResultsThe results, it is hoped, will have important clinical impact and provide essential information to improve the design of future regenerative‐medicine protocols in cardiology.ConclusionsAs cell delivery may play an important role in chronic IHD, we aim to demonstrate feasibility and efficacy of a combined cell‐delivery approach in patients with decreased LV function.