bluuebunny/crossref_metadata_2025_split huggingface dataset:
FSRW: fuzzy logic-based whale optimization algorithm for trust-aware routing in IoT-based healthcare
Authors: Xu Hui , Liu Wei-dong , Li Lu , Yao Deng-ju , Ma Lin 
Published: July 2024

AbstractThe Internet of Things (IoT) is an extensive system of interrelated devices equipped with sensors to monitor and track real world objects, spanning several verticals, covering many different industries. The IoT's promise is capturing interest as its value in healthcare continues to grow, as it can overlay on top of challenges dealing with the rising burden of chronic disease management and an aging population. To address difficulties associated with IoT-enabled healthcare, we propose a secure routing protocol that combines a fuzzy logic system and the Whale Optimization Algorithm (WOA) hierarchically. The suggested method consists of two primary approaches: the fuzzy trust strategy and the WOA-inspired clustering methodology. The first methodology plays a critical role in determining the trustworthiness of connected IoT equipment. Furthermore, a WOA-based clustering framework is implemented. A fitness function assesses the likelihood of IoT devices acting as cluster heads. This formula considers factors such as centrality, range of communication, hop count, remaining energy, and trustworthiness. Compared with other algorithms, the proposed method outperformed them in terms of network lifespan, energy usage, and packet delivery ratio by 47%, 58%, and 17.7%, respectively.
Safety, tolerability, pharmacokinetics and pharmacodynamics of milvexian with aspirin and/or clopidogrel in healthy participants
Authors: Perera Vidya , Abelian Grigor , Luettgen Joseph , Aronson Ronald , Li Danshi , Wang Zhaoqing , Zhang Liping , Lubin Susan , Merali Samira , Murthy Bindu 
Published: July 2024

AbstractMilvexian, an oral activated Factor XI (FXIa) inhibitor, is in clinical studies where it may be combined with antiplatelet agents, including aspirin and/or clopidogrel, to prevent thromboembolic diseases. This phase I trial assessed safety, pharmacokinetics, and pharmacodynamics of milvexian coadministration with aspirin and/or clopidogrel in healthy participants through 3 drug-drug interaction studies using a 3-period, 3-treatment, crossover design. A total of 113 participants were randomized to receive milvexian (200 mg; twice daily for 5 days) or matched placebo coadministered with once-daily aspirin (325 mg for 5 days) and/or clopidogrel (Day 1: 300 mg; Days 2–5: 75 mg). Milvexian was safe and well tolerated, with and without aspirin and/or clopidogrel. Eight mild bleeding adverse events (AEs) were reported in 5 of 113 participants across various treatment arms. Peak and total exposures of milvexian were similar with or without clopidogrel and/or aspirin. Exposure-dependent prolongation of activated partial thromboplastin time and reduction of FXI clotting activity by milvexian were similar with coadministration of aspirin and/or clopidogrel. Milvexian, with or without coadministration of aspirin and/or clopidogrel, did not affect bleeding time or platelet aggregation. Administration of milvexian alone or with aspirin and/or clopidogrel was safe and well tolerated without increased incidence of AEs, including bleeding. Pharmacokinetic and pharmacodynamic effects of milvexian, including bleeding time, were similar with or without aspirin and/or clopidogrel.ClinicalTrials.gov Identifier: NCT03698513.
Assessing VOC emissions from different gas stations: impacts, variations, and modeling fluctuations of air pollutants
Authors: Heidari Elham Alsadat , Sarkhosh Maryam , Alidadi Hosein , Najafpoor Ali Asghar , Esmaily Habibollah , Shamsara Elham 
Published: July 2024

AbstractGas stations distributed around densely populated areas are responsible for toxic pollutant emissions such as volatile organic compounds (VOCs). This study aims to measure VOCs emission from three different kinds of gas stations to determine the extent of pollution from the gas stations and the most frequent type of VOC compound emitted. The concentrations of ambient VOCs at three refueling stations with a different type of fuels in Mashhad were monitored. The result of this study showed that CNG fuel stations are less polluting than petrol stations. In all the studied sites, the highest concentrations were related to xylene isomers, irrespective of the fuel type. Total VOCs at the supply of both compressed natural gas (CNG) and gasoline stations was 482.36 ± 563.45 µg m−3. At a CNG station and a gasoline station, total VOC concentrations were 1363.4 ± 1975 µg m−3 and 410.29 ± 483.37 µg m−3, respectively. The differences in concentrations of toluene and m,p-xylene between the fuel stations can be related to the quality and type of fuel, vapor recovery technology, fuel reserves, dripless nozzles, traffic density in these stations, meteorological conditions and the location of sampling sites. The combination of a sine function and a quadratic function could model the fluctuation behavior of air pollutants like m,p-xylene. In all the sites, the highest concentrations were related to xylene isomers, irrespective of the type of fuel. The changing rate of m,p-xylene pollutant in each station was also modeled in this study.
PK/PD investigation of antiviral host matriptase/TMPRSS2 inhibitors in cell models
Authors: Gamba Dávid , van Eijk Nicholas , Lányi Katalin , Monostory Katalin , Steinmetzer Torsten , Marosi András , Rácz Anita , Bajusz Dávid , Kruhl Diana , Böttcher-Friebertshäuser Eva , Pászti-Gere Erzsébet 
Published: July 2024

AbstractCertain corona- and influenza viruses utilize type II transmembrane serine proteases for cell entry, making these enzymes potential drug targets for the treatment of viral respiratory infections. In this study, the cytotoxicity and inhibitory effects of seven matriptase/TMPRSS2 inhibitors (MI-21, MI-463, MI-472, MI-485, MI-1900, MI-1903, and MI-1904) on cytochrome P450 enzymes were evaluated using fluorometric assays. Additionally, their antiviral activity against influenza A virus subtypes H1N1 and H9N2 was assessed. The metabolic depletion rates of these inhibitors in human primary hepatocytes were determined over a 120-min period by LC–MS/MS, and PK parameters were calculated. The tested compounds, with the exception of MI-21, displayed potent inhibition of CYP3A4, while all compounds lacked inhibitory effects on CYP1A2, CYP2C9, CYP2C19, and CYP2D6. The differences between the CYP3A4 activity within the series were rationalized by ligand docking. Elucidation of PK parameters showed that inhibitors MI-463, MI-472, MI-485, MI-1900 and MI-1904 were more stable compounds than MI-21 and MI-1903. Anti-H1N1 properties of inhibitors MI-463 and MI-1900 and anti-H9N2 effects of MI-463 were shown at 20 and 50 µM after 24 h incubation with the inhibitors, suggesting that these inhibitors can be applied to block entry of these viruses by suppressing host matriptase/TMPRSS2-mediated cleavage.
A systematic review of the impacts of remote patient monitoring (RPM) interventions on safety, adherence, quality-of-life and cost-related outcomes
Authors: Tan Si Ying , Sumner Jennifer , Wang Yuchen , Wenjun Yip Alexander 
Published: July 2024

AbstractDue to rapid technological advancements, remote patient monitoring (RPM) technology has gained traction in recent years. While the effects of specific RPM interventions are known, few published reviews examine RPM in the context of care transitions from an inpatient hospital setting to a home environment. In this systematic review, we addressed this gap by examining the impacts of RPM interventions on patient safety, adherence, clinical and quality of life outcomes and cost-related outcomes during care transition from inpatient care to a home setting. We searched five academic databases (PubMed, CINAHL, PsycINFO, Embase and SCOPUS), screened 2606 articles, and included 29 studies from 16 countries. These studies examined seven types of RPM interventions (communication tools, computer-based systems, smartphone applications, web portals, augmented clinical devices with monitoring capabilities, wearables and standard clinical tools for intermittent monitoring). RPM interventions demonstrated positive outcomes in patient safety and adherence. RPM interventions also improved patients’ mobility and functional statuses, but the impact on other clinical and quality-of-life measures, such as physical and mental health symptoms, remains inconclusive. In terms of cost-related outcomes, there was a clear downward trend in the risks of hospital admission/readmission, length of stay, number of outpatient visits and non-hospitalisation costs. Future research should explore whether incorporating intervention components with a strong human element alongside the deployment of technology enhances the effectiveness of RPM. The review highlights the need for more economic evaluations and implementation studies that shed light on the facilitators and barriers to adopting RPM interventions in different care settings.
Normoglycemia and physiological cortisone level maintain glucose homeostasis in a pancreas-liver microphysiological system
Authors: Rigal Sophie , Casas Belén , Kanebratt Kajsa P. , Wennberg Huldt Charlotte , Magnusson Lisa U. , Müllers Erik , Karlsson Fredrik , Clausen Maryam , Hansson Sara F. , Leonard Louise , Cairns Jonathan , Jansson Löfmark Rasmus , Ämmälä Carina , Marx Uwe , Gennemark Peter , Cedersund Gunnar , Andersson Tommy B. , Vilén Liisa K. 
Published: July 2024

AbstractCurrent research on metabolic disorders and diabetes relies on animal models because multi-organ diseases cannot be well studied with standard in vitro assays. Here, we have connected cell models of key metabolic organs, the pancreas and liver, on a microfluidic chip to enable diabetes research in a human-based in vitro system. Aided by mechanistic mathematical modeling, we demonstrate that hyperglycemia and high cortisone concentration induce glucose dysregulation in the pancreas-liver microphysiological system (MPS), mimicking a diabetic phenotype seen in patients with glucocorticoid-induced diabetes. In this diseased condition, the pancreas-liver MPS displays beta-cell dysfunction, steatosis, elevated ketone-body secretion, increased glycogen storage, and upregulated gluconeogenic gene expression. Conversely, a physiological culture condition maintains glucose tolerance and beta-cell function. This method was reproducible in two laboratories and was effective in multiple pancreatic islet donors. The model also provides a platform to identify new therapeutic proteins, as demonstrated with a combined transcriptome and proteome analysis.
Membrane vectorial lipidomic features of coral host cells’ plasma membrane and lipid profiles of their endosymbionts Cladocopium
Authors: Sikorskaya Tatyana V. , Ermolenko Ekaterina V. , Ginanova Taliya T. , Boroda Andrey V. , Efimova Kseniya V. , Bogdanov Mikhail 
Published: July 2024

AbstractThe symbiotic relationships between coral animal host and autotrophic dinoflagellates are based on the mutual exchange and tight control of nutritional inputs supporting successful growth. The corals Sinularia heterospiculata and Acropora aspera were cultivated using a flow-through circulation system supplying seawater during cold and warm seasons of the year, then sorted into host cells and symbionts and subjected to phylogenetic, morphological, and advanced lipid analyses. Here we show, that the lipidomes of the dinoflagellates Cladocopium C1/C3 and acroporide-specific Cladocopium hosted by the corals, are determined by lipidomic features of different thermosensitivity and unique betaine- and phospholipid molecular species. Phosphatidylserines and ceramiaminoethylphosphonates are not detected in the symbionts and predominantly localized on the inner leaflet of the S. heterospiculata host plasma membrane. The transmembrane distribution of phosphatidylethanolamines of S. heterospiculata host changes during different seasons of the year, possibly contributing to mutualistic nutritional exchange across this membrane complex to provide the host with a secure adaptive mechanism and ecological benefits.
Discovery of giant and conventional magnetofossils bookending Cretaceous Oceanic Anoxic Event 2
Authors: Wagner Courtney L. , Lascu Ioan , Self-Trail Jean M. , Gooding Tim , Livi Kenneth J. T. , Greger Gianna , Gardner Kristina , Wycech Jody , Dreier Mark , Oliver Tom 
Published: July 2024

AbstractConventional magnetofossils are the remains of magnetotactic bacteria and giant magnetofossils are the remains of iron biomineralizing organisms that have not yet been identified. We report the oldest robust conventional and giant magnetofossil records, ~97 Ma, from marine sediments drilled in Holland Park, Virginia, USA. The Holland Park core records the Cenomanian-Turonian boundary and Oceanic-Anoxic Event 2 (OAE2). Magnetic datasets indicate single domain magnetite within the clay-rich sediments bookending OAE2. Electron microscopy images from these intervals highlight conventional and giant magnetofossil morphologies, including three potentially new giant magnetofossil morphologies: seeds, squash, and spades. There is an overall high abundance and morphological disparity of magnetofossils at Holland Park. However, we observe abundance, disparity, and preservation changes between the magnetofossil assemblages bookending OAE2. Our observations provide clues toward understanding the ecological thresholds of the enigmatic organisms that produce giant magnetofossils and evidence that magnetofossils may be widely distributed in the geologic record.
NS2 induces an influenza A RNA polymerase hexamer and acts as a transcription to replication switch
Authors: Sun Junqing , Kuai Lu , Zhang Lei , Xie Yufeng , Zhang Yanfang , Li Yan , Peng Qi , Shao Yuekun , Yang Qiuxian , Tian Wen-Xia , Zhu Junhao , Qi Jianxun , Shi Yi , Deng Tao , Gao George F 
Published: July 2024

AbstractGenome transcription and replication of influenza A virus (FluA), catalyzed by viral RNA polymerase (FluAPol), are delicately controlled across the virus life cycle. A switch from transcription to replication occurring at later stage of an infection is critical for progeny virion production and viral non-structural protein NS2 has been implicated in regulating the switch. However, the underlying regulatory mechanisms and the structure of NS2 remained elusive for years. Here, we determine the cryo-EM structure of the FluAPol-NS2 complex at ~3.0 Å resolution. Surprisingly, three domain-swapped NS2 dimers arrange three symmetrical FluPol dimers into a highly ordered barrel-like hexamer. Further structural and functional analyses demonstrate that NS2 binding not only hampers the interaction between FluAPol and the Pol II CTD because of steric conflicts, but also impairs FluAPol transcriptase activity by stalling it in the replicase conformation. Moreover, this is the first visualization of the full-length NS2 structure. Our findings uncover key molecular mechanisms of the FluA transcription-replication switch and have implications for the development of antivirals.
Kopfschmerz bei Medikamentenübergebrauch
Authors: Naegel Steffen 
Published: July 2024

ZusammenfassungDer Kopfschmerz durch Medikamentenübergebrauch (MOH) ist eine weltweit
verbreitete und beeinträchtigende Erkrankung, die durch übermäßige Einnahme von
Akuttherapie entsteht und die Lebensqualität erheblich beeinträchtigen kann und
das obwohl z.B. einfache Informationen über Ursachen und Folgen der Erkrankung
dazu beitragen können, den MOH zu verhindern oder zu beenden. In den letzten
Jahren konnten viele neue Erkenntnisse zum Kopfschmerz durch
Medikamentenübergebrauch generiert werden. Zudem haben sich die
Diagnosekriterien und die Leitlinienempfehlungen umfassend gewandelt. Dieser
Artikel bietet einen umfassenden Überblick über die Klinik,
Definition/Klassifikation, Epidemiologie, Risikofaktoren, Pathophysiologie,
Kontroversen, Prävention und Behandlung des MOH.
Chemical Methods for the Construction of Spirocyclic β-Lactams and Their Biological Importance
Authors: Berry Shiwani , Bhalla Aman , Yadav Pooja 
Published: July 2024

AbstractSpirocyclic β-lactams are a family of natural and synthetic chemicals with different biological activities, including antibacterial properties, and interact with critical physiological targets such as T-type calcium channels and acetyl-CoA cholesterol acyltransferase. Their unique chemical structure, combining a spiro ring system with a β-lactam group, offers promising opportunities for the targeted discovery of medications in medicinal chemistry. Spirocyclic β-lactams have the potential to be adaptable frameworks for developing novel therapeutic medicines with particular three-dimensional pharmacophoric characteristics and increased biological efficacy. Numerous methods are employed for the synthesis of spirocyclic β-lactams, such as cyclization, functional group modifications, asymmetric synthesis utilizing chiral catalysts and biomimetic approaches. In this short review, two distinct approaches describing recent syntheses of spirocyclic β-lactams (from 2021 to 2024) are discussed. The first is based on constructing the β-lactam ring, while the other entails transforming monocyclic β-lactams into spirocyclic structures. These methods include detailed reaction processes and descriptions of the biological functions of the target spirocycles. The applications of spirocyclic β-lactams in medicinal chemistry highlight their role in the synthesis of structurally diverse compounds with significant therapeutic potential, demonstrating creative chemical methods for building complex molecular structures.1	Introduction2	β-Lactam Ring Synthesis3	Non-β-Lactam Ring Synthesis4	Miscellaneous Examples5	Conclusion and Outlook
Lewis Acid Mediated Synthesis of 4-Aminoquinoline Derivatives from 2-Aminobenzonitriles and Activated Alkynes via Aza-Michael and Annulation Reactions
Authors: Saikia Anil K. , Porashar Bikoshita 
Published: July 2024

AbstractAn efficient methodology for the synthesis of highly diverse 4-aminoquinoline derivatives from activated alkynes and 2-aminobenzonitriles mediated by Lewis acid is described. The reaction proceeds via sequential aza-Michael addition/intramolecular annulation to afford highly substituted 4-aminoquinolines in good yields. The reaction is operationally simple and has high atom-economy with broad substrate scope. The post synthetic application of the reaction provides 4H-benzo[de][1,6]naphthyridines.
Correlation of endoscopic ultrasound-guided portal pressure gradient measurements with hepatic venous pressure gradient: a prospective study
Authors: Martinez-Moreno Belén , Martínez Martínez Juan , Herrera Iván , Guilabert Lucía , Rodríguez-Soler María , Bellot Pablo , Miralles Cayetano , Pascual Sonia , Irúrzun Javier , Zapater Pedro , Palazón-Azorín José María , Gil Guillén Vicente , Jover Rodrigo , Aparicio José R. 
Published: July 2024

Abstract
Background Hepatic venous portal gradient (HVPG) measurement remains the gold standard for estimating portal pressure gradient (PPG). This study aimed to evaluate the correlation between endoscopic ultrasound (EUS)-guided PPG and HVPG in patients with chronic portal hypertension.
Methods Patients with chronic portal hypertension in whom HVPG assessment was clinically indicated were invited to undergo transjugular HVPG and EUS-PPG with a 22-G needle in separate sessions for comparison. Intraclass correlation coefficient (ICC) and the Bland–Altman method were used to evaluate the agreement between techniques.
Results 33 patients were included. No significant differences in technical success were observed: EUS-PPG (31/33, 93.9%) vs. HVPG (31/33, 93.9%). Overall, 30 patients who underwent successful EUS-PPG and HVPG were analyzed. Correlation between the two techniques showed an ICC of 0.82 (0.65–0.91). Four patients had major discrepancies (≥5 mmHg) between HVPG and EUS-PPG. No significant differences in adverse events were observed.
Conclusions The correlation between EUS-PPG and HVPG was almost perfect. EUS-PPG could be a safe and reliable method for direct PPG measurement in patients with cirrhosis and a valid alternative to HVPG.
Reha-Empfehlungen nach § 31 SGB XI: Empirie, Diskussion und
gesundheitspolitische Implikationen
Authors: Herberg Stephan , Zerth Juergen , Hammer Jonas , Teuteberg Frank 
Published: July 2024

Zusammenfassung
Hintergrund Das Prinzip „Rehabilitation vor Pflege“ ist ein
sozialrechtlicher Grundsatz. Einen wichtigen Stellenwert bei den
Rehabilitationsempfehlungen nimmt die Empfehlung des Medizinischen Dienstes (MD)
im Rahmen der Begutachtung (§ 31 SGB XI) ein. Bei rund drei Prozent seiner
Begutachtungen empfiehlt der MD die Durchführung einer Rehabilitation. Nur bei
jeder vierten bis fünften Empfehlung folgt der Empfehlung eine tatsächliche
Durchführung der Rehabilitationsmaßnahme.
Ziel der Arbeit Diskutiert werden soll anhand einer Versichertenbefragung
der Aspekt, ob die rehabilitativen Potentiale genutzt und ausgeschöpft werden,
die aus der Rehabilitationsempfehlung entstehen.
Material und Methoden Diese Arbeit untersucht insbesondere die Perspektive
der Versicherten, die einer Rehabilitationsmaßnahme zugestimmt haben und deren
Rehabilitation auch durchgeführt wurde. Nach Auswertung von 586 228
Routindatensätzen mit Pflegebegutachtungen des MD wurden im März 2023 1972
Befragungsbögen versandt, 1116 auswertbare Fragebögen konnten in die
Datenauswertung einbezogen werden. In sieben Fragen wurden die Befragten
gebeten, retrospektiv den Erfolg und die Zufriedenheit mit der Rehabilitation
insgesamt und der Wirksamkeit der durchgeführten Therapien einzuschätzen.
Ergebnisse Die Auswertung der Ergebnisse zeigt dabei, dass 87 Prozent der
Studienteilnehmer eine Rehabilitation wiederholen würden. Auch die Einschätzung
zum Reha-Erfolg in Bezug auf den längeren Verbleib in der eigenen Häuslichkeit
hat Gewicht. Auf der anderen Seite werden nach wie vor nur rund 10 Prozent der
durchgeführten Rehabilitationen ambulant durchgeführt.
Schlussfolgerungen Als eine Begründung für die geringe Teilnahme an
Rehabilitationsmaßnahmen wurde bisher angenommen, dass Pflegebedürftige im Jahr
vor der Reha-Empfehlung schon Maßnahmen der Rehabilitation erhalten hätten. Die
Ergebnisse der Auswertung der Routinedaten einer Krankenkasse können diese
Annahme jedoch widerlegen. So richtet sich der Blick auf die angebotenen und
dann wahrgenommen Möglichkeiten, Reha-Leistungen in Anspruch zu nehmen. Es gilt
zu diskutieren, ob die in Deutschland noch starke Ausrichtung auf stationäre
Rehabilitation sowohl medizinisch als auch mit Blick auf die Präferenzen der
Rehaberechtigten zeitgemäß sind. Aspekte für individuelle, ambulante und ggf.
mobile Rehabilitationsangebote können daher geeignetere Mittel der Wahl sein,
die auch den Ansprüchen an individuelle Mobilität und Autonomie und dem Wunsch,
Reha in ein häusliches Umfeld einzupassen, gerecht werden.
Quadriceps Architectural Adaptations in Team Sports Players: A
Meta-analysis
Authors: Pecci Javier , Sañudo Borja , Sanchez-Trigo Horacio , Reverte-Pagola Gonzalo , Pareja-Galeano Helios 
Published: July 2024

AbstractResistance training is the most effective strategy to modify muscle architecture,
enhancing sport performance and reducing injury risk. The aim of this study was
to compare the effects of high loads (HL) versus lower loads (LL), maximal
versus submaximal efforts, and high frequency (HF) versus low frequency (LF) on
quadriceps architectural adaptations in team sports players. Five databases were
searched. Vastus lateralis thickness, fascicle length and pennation angle, and
rectus femoris thickness were analyzed as main outcomes. Overall, resistance
training significantly improved muscle thickness and pennation angle, but not
fascicle length. LL led to greater fascicle length adaptations in the vastus
lateralis compared to HL (p=0.01), while no substantial differences were found
for other load comparisons. Degree of effort and training frequency did not show
meaningful differences (p>0.05). In conclusion, LL lengthen the fascicle to a
greater extent than HL, and training with LL twice a week could maximize
architectural adaptations, whereas the degree of effort does not appear to be a
determinant variable on quadriceps architectural adaptations.