bluuebunny/crossref_metadata_2025_split huggingface dataset:
Similarities and differences between the solar wind light noble gas compositions determined on Apollo 15 SWC foils and on NASA Genesis targets
Authors: Vogel N. , Bochsler P. , Bühler F. , Heber V. S. , Grimberg A. , Baur H. , Horstmann M. , Bischoff A. , Wieler R. 
Published: September 2015

AbstractWe compare the solar wind (SW) He, Ne, and Ar compositions collected during the Apollo Solar Wind Composition (SWC) experiments (1969–1972; Al‐ & Pt‐foils) and the Genesis mission (2002–2004; so‐called DOS targets considered here). While published SW 20Ne/22Ne and 36Ar/38Ar ratios of both data sets agree, differences exist in the 4He/3He, 4He/20Ne, and 20Ne/36Ar ratios. However, 20Ne/36Ar ratios from Apollo‐16 Pt‐foils, exclusively adopted as SW values by the SWC team, are consistent with the Genesis results. We investigate if the differences indicate a variability of the SW over the course of about 30 yr, or systematic biases of the two data sets, which were collected in different environments and measured several decades apart in different laboratories (University of Bern; ETH Zurich). New measurements of Apollo‐15 SWC aluminum foils in Zurich generally agree with the original measurements performed in Bern. Zurich samples show slightly lower 4He concentrations suggesting a few percent of diffusive loss of 4He during storage of the foils. A 3% difference between the He isotopic ratios measured in Bern and in Zurich possibly represents an analytical bias between the laboratories. The low SW 4He/20Ne and 20Ne/36Ar ratios in Apollo‐15 Al‐foils compared to Genesis data are consistent with a mixture of Genesis‐like SW and noble gases from small amounts of lunar dust. Our data suggest that the mean SW He, Ne, and Ar isotopic and elemental compositions have not significantly changed between the overall Apollo and Genesis mission collection periods.
Extra‐fine particle inhaled corticosteroids, pharma‐cokinetics and systemic activity in children with asthma
Authors: Wolthers Ole D. 
Published: September 2015

AbstractDuring recent years, extra‐fine particle inhaled corticosteroids with a median aerodynamic diameter ≤2 μm have been introduced in the treatment of asthma. The aim of this paper was to review pharmacokinetics and systemic activity of extra‐fine particle hydroalkane pressurized metered dose inhaled (pMDI) ciclesonide and beclomethasone dipropionate in children. A literature review was performed. Systemic bioavailability of oral and pulmonary deposition of extra‐fine ciclesonide and beclomethasone dipropionate was 52% and 82%, the half‐life in serum 3.2 and 1.5 h and first‐pass hepatic metabolism >99% and 60%, respectively. Secondary analyses of urine cortisol/creatinine excretion found no effects of ciclesonide pMDI between 40 and 320 μg/day or of beclomethasone dipropionate pMDI between 80 and 400 μg/day. Ciclesonide pMDI 40, 80 and 160 μg/day caused no effects on short‐term lower leg growth rate as assessed by knemometry. Ciclesonide 320 μg/day was associated with a numerically short‐term growth suppression equivalent to 30% which was similar to 25% and 36% suppression caused by beclomethasone dipropionate HFA and CFC 200 μg/day, respectively. Consistent with the differences in key pharmacokinetic features, beclomethasone dipropionate is associated with a systemic activity detected by knemometry at a lower dose than ciclesonide. Whether that correlates with a clinically important difference remains to be explored. Assessments of systemic activity of beclomethasone dipropionate <200 μg/day and of ciclesonide >180 μg/day as well as head‐to‐head comparisons are warranted. Preferably, such studies should apply the sensitive method of knemometry.
Infective endocarditis associated with acute leukemia: Report of two cases
Authors: Keino Dai , Tsuzuki Yoshimitsu , Mori Takashi , Kakuage Shiori , Nakano Marie , Asoh Kentaro , Mori Tetsuya , Kinoshita Akitoshi , Yamamoto Hitoshi 
Published: September 2015

AbstractThere have been few reports regarding infective endocarditis (IE) in patients with leukemia. In the first case, a 15‐year‐old girl with Down syndrome was diagnosed with acute lymphoblastic leukemia. On admission, methicillin‐sensitive Staphylococcus aureus (MSSA) was detected on blood culture. Echocardiography was performed because MSSA was detected repeatedly even after treatment. Vegetation in all of the atria and ventricles met the Duke criteria defining IE. She died of multiple organ failure 21 days after diagnosis. In the second case, an 11‐year‐old boy with acute myeloid leukemia underwent peripheral blood stem cell transplantation (PBSCT). He had fever 68 days after PBSCT, and methicillin‐resistant S. aureus (MRSA) was detected on blood culture. Echocardiography showed vegetation in the right atrium and ventricle. Daptomycin was administered for 7 weeks, and recurrence was not observed. IE should be considered when S. aureus bacteremia is documented even in patients with leukemia.
Removal of Phosphorus by Hemodialysis
Authors: Daugirdas John T. 
Published: September 2015

AbstractThe control of serum phosphorus by dialysis is made difficult by the fact that intradialytic blood levels tend to be low, and because phosphorus is removed almost exclusively from the plasma during its passage through the dialyzer. The most practical way to increase phosphorus removal is to extend dialysis time, although attention to dialysis efficiency (surface area, advanced membrane, and higher blood and dialysate flow rates) also plays a role. Benefits of hemodiafiltration in helping control serum phosphorus have been claimed, but not found in all studies. Because serum phosphorus levels tend to plateau during the later parts of a dialysis session, extending weekly dialysis time is of greater benefit for phosphorus removal than for urea removal. Increasing dialysis frequency also probably has a small benefit. It appears that 18–30 hours of dialysis per week are required to obviate the need for phosphorus binders. Several promising models of phosphorus kinetics are under development. These may help predict the change in treatment on serum phosphorus levels, but their ability to do so has not yet been critically assessed.
Molecular Characterization and Serology of Leptospira kirschneri (Serogroup Grippotyphosa) Isolated from Urine of a Mare Post‐Abortion in Brazil
Authors: Hamond C. , Martins G. , Bremont S. , Medeiros M. A. , Bourhy P. , Lilenbaum W. 
Published: September 2015

SummaryA strain of Leptospira kirschneri (serogroup Grippotyphosa) was cultured from urine of a mare post‐abortion in Brazil and characterized by serogrouping, multiple‐locus variable‐number tandem repeat analysis, PGFE, and sequencing of genes rrs and secY. Strains of L. kirschneri have apparently never been recovered from horses in tropical area, only in Europe and USA. Knowledge of local epidemiology is important to interpret genetic profiles of leptospires circulating in an area.
Antimicrobial Resistance of Faecal Escherichia coli Isolates from Pig Farms with Different Durations of In‐feed Antimicrobial Use
Authors: Gibbons J. F. , Boland F. , Egan J. , Fanning S. , Markey B. K. , Leonard F. C. 
Published: September 2015

SummaryAntimicrobial use and resistance in animal and food production are of concern to public health. The primary aims of this study were to determine the frequency of resistance to 12 antimicrobials in Escherichia coli isolates from 39 pig farms and to identify patterns of antimicrobial use on these farms. Further aims were to determine whether a categorization of farms based on the duration of in‐feed antimicrobial use (long‐term versus short‐term) could predict the occurrence of resistance on these farms and to identify the usage of specific antimicrobial drugs associated with the occurrence of resistance. Escherichia coli were isolated from all production stages on these farms; susceptibility testing was carried out against a panel of antimicrobials. Antimicrobial prescribing data were collected, and farms were categorized as long term or short term based on these. Resistance frequencies and antimicrobial use were tabulated. Logistic regression models of resistance to each antimicrobial were constructed with stage of production, duration of antimicrobial use and the use of 5 antimicrobial classes included as explanatory variables in each model. The greatest frequencies of resistance were observed to tetracycline, trimethoprim/sulphamethoxazole and streptomycin with the highest levels of resistance observed in isolates from first‐stage weaned pigs. Differences in the types of antimicrobial drugs used were noted between long‐term and short‐term use farms. Categorization of farms as long‐ or short‐term use was sufficient to predict the likely occurrence of resistance to 3 antimicrobial classes and could provide an aid in the control of resistance in the food chain. Stage of production was a significant predictor variable in all models of resistance constructed and did not solely reflect antimicrobial use at each stage. Cross‐selection and co‐selection for resistance was evident in the models constructed, and the use of trimethoprim/sulphonamide drugs in particular was associated with the occurrence of resistance to other antimicrobials.
Influence of Pastoralists’ Sociocultural Activities on Tsetse–Trypanosome–Cattle Reservoir Interface: The Risk of Human African Trypanosomiasis in North‐Central Nigeria
Authors: Alhaji N. B. , Kabir J. 
Published: September 2015

SummaryThe study investigated socio‐cultural characteristics of pastoralists that influenced on the tsetse‐trypanosome‐cattle reservoir interface thereby predisposing them to HAT in Niger State, North‐central Nigeria. It was a cross‐sectional survey of adult pastoral herders, aged 30 years and above, and conducted between October 2012 and February 2013. A face‐to‐face structured questionnaire was administered on the pastoralists nested in 96 cattle herds with questions focused on pastoralists’ socio‐cultural activities and behavioral practices related to HAT risk. Descriptive and analytic statistics were used to describe the obtained data. A total of 384 pastoralists participated, with mean age of 49.6 Â ± 10.76 SD years. Male respondents constituted 86.7% of gender, while pastoralists of age group 40–49 years constituted 35.4% of respondents. About 59.4% of the pastoralists had knowledge about HAT and its symptoms and only 33.9% of them believed that cattle served as reservoir of HAT trypanosome. Knowledge/belief levels of the pastoralists about African trypanosomiasis occurrence in humans and animals were statistically significant. Males were four times more likely to be exposed to HAT (OR = 3.67; 95% CI: 1.42, 9.52); age group 60–69 was also four times more likely to be exposed (OR = 3.59; 95% CI: 1.56, 8.28); and nomadic pastoralists were two times more likely to be exposed to HAT (OR = 2.07; 95% CI: 1.37, 3.14). All cultural practices significantly influenced exposure to HAT with extensive husbandry system three times more likely to predisposed pastoralists to HAT (OR = 3.21; 95% CI: 1.65, 6.24). Socio‐cultural characteristics of pastoralists influenced exposure to HAT risk and, therefore, there is a need to sensitize them to bring changes to their socio‐cultural practices and perceptions to achieve effective and long term sustainable HAT control. Elimination strategies of parasites in animals and vectors should be considered to avoid reintroduction from animal reservoirs.
The Beneficial Effect of Parasympathetic Reactivation on Sympathetic Drive During Simulated Rugby Sevens
Authors: Douglas Jamie , Plews Daniel J. , Handcock Phil J. , Rehrer Nancy J. 
Published: September 2015

Purpose:To determine whether a facilitated recovery via cold-water immersion (CWI) after simulated rugby sevens would influence parasympathetic reactivation and repeated-sprint (RS) performance across 6 matches in a 2-d tournament.Methods:Ten male team-sport athletes completed 6 rugby sevens match simulations over 2 d with either postmatch passive recovery (PAS) or CWI in a randomized crossover design. Parasympathetic reactivation was determined via the natural logarithm of the square root of the mean of the sum of the squares of differences between adjacent R-R intervals (ln rMSSD). RS performance was calculated as time taken (s) to complete 6 × 30-m sprints within the first half of each match.Results:There were large increases in postintervention ln rMSSD between CWI and PAS after all matches (ES 90% CL: +1.13; ±0.21). Average heart rate (HR) during the RS performance task (HRAverage RS) was impaired from baseline from match 3 onward for both conditions. However, HRAverage RS was higher with CWI than with PAS (ES 90% CL: 0.58; ±0.58). Peak HR during the RS performance task (HRPeak RS) was similarly impaired from baseline for match 3 onward during PAS and for match 4 onward with CWI. HRPeak RS was very likely higher with CWI than with PAS (ES 90% CL: +0.80; ±0.56). No effects of match or condition were observed for RS performance, although there were moderate correlations between the changes in HRAverage RS (r 90% CL: –0.33; ±0.14), HRPeak RS (r 90% CL: –0.38; ±0.13), and RS performance.Conclusion:CWI facilitated cardiac parasympathetic reactivation after a simulated rugby sevens match. The decline in average and peak HR across matches was partially attenuated by CWI. This decline was moderately correlated with a reduction in RS performance.
Draft Genome Sequence of Parabacteroides goldsteinii with Putative Novel Metallo-β-Lactamases Isolated from a Blood Culture from a Human Patient
Authors: Krogh Thøger Jensen , Agergaard Charlotte Nielsen , Møller-Jensen Jakob , Justesen Ulrik Stenz 
Published: September 2015

ABSTRACT

Parabacteroides goldsteinii
was isolated from a blood culture. Genomic DNA was sequenced using a MiSeq sequencer and assembled using the SPAdes genome assembler. The draft genome sequence was 6,851,868 bp, spanning 282 contigs of 5,253 coding sequences, 66 tRNAs, and 5 rRNAs. Several putative novel metallo-β-lactamases were discovered.
Draft Genome Sequences of Three Chromobacterium subtsugae Isolates from Wild and Cultivated Cranberry Bogs in Southeastern Massachusetts
Authors: Vöing Kristin , Harrison Alisha , Soby Scott D. 
Published: September 2015

ABSTRACT

Chromobacterium subtsugae
was isolated from cranberry bogs in Massachusetts. While it is unknown what environmental role these bacteria play in bog soils, they hold potential as biological control agents against the larvae of insect pests. Potential virulence genes were identified, including the violacein synthesis pathway, siderophores, and several chitinases.
Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
Authors: Pellegrino Marsha , Mancini Francesca , Lucà Rossella , Coletti Alice , Giacchè Nicola , Manni Isabella , Arisi Ivan , Florenzano Fulvio , Teveroni Emanuela , Buttarelli Marianna , Fici Laura , Brandi Rossella , Bruno Tiziana , Fanciulli Maurizio , D'Onofrio Mara , Piaggio Giulia , Pellicciari Roberto , Pontecorvi Alfredo , Marine Jean Christophe , Macchiarulo Antonio , Moretti Fabiola 
Published: September 2015

Abstract
Restoration of wild-type p53 tumor suppressor function has emerged as an attractive anticancer strategy. Therapeutics targeting the two p53-negative regulators, MDM2 and MDM4, have been developed, but most agents selectively target the ability of only one of these molecules to interact with p53, leaving the other free to operate. Therefore, we developed a method that targets the activity of MDM2 and MDM4 simultaneously based on recent studies indicating that formation of MDM2/MDM4 heterodimer complexes are required for efficient inactivation of p53 function. Using computational and mutagenesis analyses of the heterodimer binding interface, we identified a peptide that mimics the MDM4 C-terminus, competes with endogenous MDM4 for MDM2 binding, and activates p53 function. This peptide induces p53-dependent apoptosis in vitro and reduces tumor growth in vivo. Interestingly, interfering with the MDM2/MDM4 heterodimer specifically activates a p53-dependent oxidative stress response. Consistently, distinct subcellular pools of MDM2/MDM4 complexes were differentially sensitive to the peptide; nuclear MDM2/MDM4 complexes were particularly highly susceptible to the peptide-displacement activity. Taken together, these data identify the MDM2/MDM4 interaction interface as a valuable molecular target for therapeutic reactivation of p53 oncosuppressive function. Cancer Res; 75(21); 4560–72. ©2015 AACR.
International Variation in Female Breast Cancer Incidence and Mortality Rates
Authors: DeSantis Carol E. , Bray Freddie , Ferlay Jacques , Lortet-Tieulent Joannie , Anderson Benjamin O. , Jemal Ahmedin 
Published: September 2015

Abstract
Background: Breast cancer is the most frequently diagnosed cancer and the leading cause of cancer-related death among women worldwide. Herein, we examine global trends in female breast cancer rates using the most up-to-date data available.
Methods: Breast cancer incidence and mortality estimates were obtained from GLOBOCAN 2012 (globocan.iarc.fr). We analyzed trends from 1993 onward using incidence data from 39 countries from the International Agency for Research on Cancer and mortality data from 57 countries from the World Health Organization.
Results: Of 32 countries with incidence and mortality data, rates in the recent period diverged—with incidence increasing and mortality decreasing—in nine countries mainly in Northern/Western Europe. Both incidence and mortality decreased in France, Israel, Italy, Norway, and Spain. In contrast, incidence and death rates both increased in Colombia, Ecuador, and Japan. Death rates also increased in Brazil, Egypt, Guatemala, Kuwait, Mauritius, Mexico, and Moldova.
Conclusions: Breast cancer mortality rates are decreasing in most high-income countries, despite increasing or stable incidence rates. In contrast and of concern are the increasing incidence and mortality rates in a number of countries, particularly those undergoing rapid changes in human development. Wide variations in breast cancer rates and trends reflect differences in patterns of risk factors and access to and availability of early detection and timely treatment.
Impact: Increased awareness about breast cancer and the benefits of early detection and improved access to treatment must be prioritized to successfully implement breast cancer control programs, particularly in transitioning countries. Cancer Epidemiol Biomarkers Prev; 24(10); 1495–506. ©2015 AACR.
Sleep Duration, Sleep Quality, and Markers of Subclinical Arterial Disease in Healthy Men and Women
Authors: Kim Chan-Won , Chang Yoosoo , Zhao Di , Cainzos-Achirica Miguel , Ryu Seungho , Jung Hyun-Suk , Yun Kyung Eun , Choi Yuni , Ahn Jiin , Zhang Yiyi , Rampal Sanjay , Baek Youngji , Lima Joao A. , Shin Hocheol , Guallar Eliseo , Cho Juhee , Sung Eunju 
Published: September 2015

Objective—
Short and long sleep duration are associated with increased risk of clinical cardiovascular events, but the association between sleep duration and subclinical cardiovascular disease is not well established. We examined the association between sleep duration and sleep quality with coronary artery calcification (CAC) and with brachial–ankle pulse wave velocity (PWV) in a large sample of young and middle-aged asymptomatic adults.

Approach and Results—

We conducted a cross-sectional study of adult men and women who underwent a health checkup examination, including assessment of sleep duration and quality and coupled with either CAC (n=29 203) or brachial–ankle PWV (n=18 106). The multivariate-adjusted CAC score ratios (95% confidence interval) comparing sleep durations of ≤5, 6, 8, and ≥9 hours with 7 hours of sleep were 1.50 (1.17–1.93), 1.34 (1.10–1.63), 1.37 (0.99–1.89), and 1.72 (0.90–3.28), respectively (
P
for quadratic trend=0.002). The corresponding average differences in brachial–ankle PWV were 6.7 (0.75–12.6), 2.9 (−1.7 to 7.4), 10.5 (4.5–16.5), and 9.6 (−0.7 to 19.8) cm/s, respectively (
P
for quadratic trend=0.019). Poor subjective sleep quality was associated with CAC in women but not in men, whereas the association between poor subjective sleep quality and brachial–ankle PWV was stronger in men than in women.

Conclusions—
In this large study of apparently healthy men and women, extreme sleep duration and poor subjective sleep quality were associated with increased prevalence of CAC and higher PWV. Our results underscore the importance of an adequate quantity and quality of sleep to maintain cardiovascular health.
Ibrutinib Inhibits Platelet Integrin α
IIb
β
3
Outside-In Signaling and Thrombus Stability But Not Adhesion to Collagen
Authors: Bye Alexander P. , Unsworth Amanda J. , Vaiyapuri Sakthivel , Stainer Alexander R. , Fry Michael J. , Gibbins Jonathan M. 
Published: September 2015

Objective—
Ibrutinib is an irreversible Bruton tyrosine kinase inhibitor approved for treatment of Waldenstrom macroglobulinemia, chronic lymphocytic leukemia, and mantle cell lymphoma that increases the risk of bleeding among patients. Platelets from ibrutinib-treated patients exhibit deficiencies in collagen-evoked signaling in suspension; however, the significance of this observation and how it relates to bleeding risk is unclear, as platelets encounter immobile collagen in vivo. We sought to clarify the effects of ibrutinib on platelet function to better understand the mechanism underlying bleeding risk.

Approach and Results—

By comparing signaling in suspension and during adhesion to immobilized ligands, we found that the collagen signaling deficiency caused by ibrutinib is milder during adhesion to immobilized collagen. We also found that platelets in whole blood treated with ibrutinib adhered to collagen under arterial shear but formed unstable thrombi, suggesting that the collagen signaling deficiency caused by ibrutinib may not be the predominant cause of bleeding in vivo. However, clot retraction and signaling evoked by platelet adhesion to immobilized fibrinogen were also inhibited by ibrutinib, indicating that integrin α
IIb
β
3
outside-in signaling is also effected in addition to GPVI signaling. When ibrutinib was combined with the P2Y
12
inhibitor, cangrelor, thrombus formation under arterial shear was inhibited additively.

Conclusions—

These findings suggest that (1) ibrutinib causes GPVI and integrin α
IIb
β
3
platelet signaling deficiencies that result in formation of unstable thrombi and may contribute toward bleeding observed in vivo and (2) combining ibrutinib with P2Y
12
antagonists, which also inhibit thrombus stability, may have a detrimental effect on hemostasis.