bluuebunny/crossref_metadata_2025_split huggingface dataset:
Methodological reflections on radio and podcast listenership in political geography
Authors: Watson Alice 
Published: July 2024

AbstractThis paper makes a novel intervention in political geography by offering methodological reflections on contemporary radio and podcast listenership. It begins from the starting point that radio and podcasts are important and popular sites of geographical knowledge production with the power to shape how audiences understand, imagine and engage in the world. The paper heeds calls in critical and popular geopolitics to move away from the site of representation towards audience reception and presents the ‘playlist‐diary’ method as an innovative way of exploring listener responses to BBC radio journalism on migration. This method is then used as a springboard to think more broadly about everyday encounters with radio and podcasts. It argues that situating audience engagements within specific spatialities and temporalities, and considering the digital technologies and platforms though which audio is discovered, consumed and circulated, is critical to developing a nuanced understanding of radio and podcast geopolitics. This discussion reflects growing interest in materialities, networks and assemblages of popular geopolitics and points to a blurring of visual and aural media. Overall, the paper makes the case for amplifying methodologies of listening in political geography and aims to be a catalyst to future scholarship on radio and podcasts.
A characterization of patients with low soluble urokinase plasminogen activator receptor who died within 90 days of hospital discharge
Authors: Christensen Louise Westberg Strejby , Iversen Esben , Andersen Aino Leegaard , Walls Anne Byriel , Rasmussen Line Jee Hartmann , Andersen Ove , Kallemose Thomas , Houlind Morten Baltzer 
Published: July 2024

AbstractSoluble urokinase plasminogen activator receptor (suPAR) is a marker of systemic chronic inflammation. Elevated suPAR levels are associated with adverse clinical outcomes, but a small subset of patients with low suPAR also experience poor outcomes. Therefore, we aimed to characterize patients presenting to the emergency department with low suPAR (<3 ng/mL) who died within 90 days after discharge in a registry‐based study. Compared to patients with low suPAR who survived (n = 15 122), those who died within 90 days (n = 87) had higher age (75.4 years), higher medication use (7.0; 71.3% with polypharmacy) and more blood tests outside reference intervals (5.0) (including C‐reactive protein, neutrophils and albumin), and the most common diagnoses were chronic pulmonary disease (27.6%), cerebrovascular disease (18.4%) and dementia (11.5%). Patients with low suPAR were more morbid than what was reflected by suPAR alone. Future studies must determine which factors that contribute the most to potential algorithms when stratifying patients based on their risk of adverse clinical outcomes. These data indicate that inclusion of medication data could be relevant.
Debate: How the business model of social media fuels the need for greater moderation
Authors: Graham Richard 
Published: July 2024

The current business model of social media companies is to keep users engaged and on screen, so that data can be obtained from them, and targeted advertisements sold. To maintain user engagement, recommender systems (algorithms) promote content, which can be extreme, and includes mental health content. Extreme mental health content, such as self‐harm images, can be pushed to any user and then more and more extreme content can be pushed to them. The normalisation, amplification or glamorisation of harmful content can have negative impacts upon the user, who may struggle to express what is happening online to anyone. In contrast with the views of Zhang et al. (Child and Adolescent Mental Health, 2024, 29, 104), without greater, timely moderation of harmful content, the promotion of self‐harm, suicide and eating disorders will continue on social media, with potentially devastating consequences.
MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression
Authors: Hou Wei , Chen Juan , Wang Yaoyuan 
Published: July 2024

ABSTRACTBackgroundMitochondrial ribosomal protein L35 (MRPL35) has been reported to contribute to the growth of non–small cell lung cancer (NSCLC) cells. However, the functions and mechanisms of MRPL35 on glutamine metabolism in NSCLC remain unclear.MethodsThe detection of mRNA and protein of MRPL35, ubiquitin‐specific protease 39 (USP39), and solute carrier family 7 member 5 (SLC7A5) was conducted using qRT‐PCR and western blotting. Cell proliferation, apoptosis, and invasion were evaluated using the MTT assay, EdU assay, flow cytometry, and transwell assay, respectively. Glutamine metabolism was analyzed by detecting glutamine consumption, α‐ketoglutarate level, and glutamate production. Cellular ubiquitination analyzed the deubiquitination effect of USP39 on MRPL35. An animal experiment was conducted for in vivo analysis.ResultsMRPL35 was highly expressed in NSCLC tissues and cell lines, and high MRPL35 expression predicted poor outcome in NSCLC patients. In vitro analyses suggested that MRPL35 knockdown suppressed NSCLC cell proliferation, invasion, and glutamine metabolism. Moreover, MRPL35 silencing hindered tumor growth in vivo. Mechanistically, USP39 stabilized MRPL35 expression by deubiquitination and then promoted NSCLC cell proliferation, invasion, and glutamine metabolism. In addition, MRPL35 positively affected SLC7A5 expression in NSCLC cells in vitro and in vivo. Moreover, the anticancer effects of MRPL35 silencing could be rescued by SLC7A5 overexpression in NSCLC cells.ConclusionMRPL35 expression was stabilized by USP39‐induced deubiquitination in NSCLC cells, and knockdown of MRPL35 suppressed NSCLC cell proliferation, invasion, and glutamine metabolism in vitro and impeded tumor growth in vivo by upregulating SLC7A5, providing a promising therapeutic target for NSCLC.
Dalzanemdor (SAGE‐718), a novel, investigational N‐methyl‐D‐aspartate receptor positive allosteric modulator: Safety, tolerability, and clinical pharmacology in randomized dose‐finding studies in healthy participants and an open‐label study in participants with Huntington's disease
Authors: Koenig Aaron , Lewis Michael , Wald Jeff , Li Sigui , Varoglu Mustafa , Dai Jing , Sankoh Abdul , Paumier Katrina , Doherty James , Quirk Mike 
Published: July 2024

AbstractN‐methyl‐D‐aspartate receptor (NMDAR)‐positive allosteric modulators (PAMs) represent a potential therapeutic strategy for cognitive impairment in disorders associated with NMDAR hypofunction, including Huntington's disease (HD) and Alzheimer's disease. Dalzanemdor (SAGE‐718) is a novel, investigational NMDAR PAM being evaluated for the potential treatment of cognitive impairment in these disorders. We report first‐in‐human, phase I, double‐blind, dose‐finding studies to assess the safety, tolerability, and clinical pharmacology of dalzanemdor. A single‐ascending dose study (dalzanemdor 0.35, 0.75, 1.5, or 3.0 mg vs. placebo) was conducted in healthy participants and included food effects. A multiple‐ascending dose study (14 days) was conducted in healthy participants (dalzanemdor 0.5 or 1.0 mg vs. placebo) and HD participants (open‐label dalzanemdor 1.0 mg) and included exploratory pharmacodynamics on cognitive performance. Dalzanemdor was generally well tolerated with no adverse events leading to discontinuation. Dalzanemdor exhibited pharmacokinetic parameters appropriate for once‐daily dosing. Following single and multiple doses in healthy participants, median terminal half‐life was 8–118 h, and the median time to reach maximum plasma concentration was 4–7 h. Exposures were dose‐proportional after single dose (6–46 ng/mL) and more than dose‐proportional after multiple doses (6–41 ng/mL). With multiple dosing, a steady state was achieved after 11 days in healthy participants and 13 days in HD participants. Dalzanemdor exposure decreased slightly with food. In HD participants, results suggest that dalzanemdor may improve cognitive performance on tests of executive function. These results support continued clinical development of dalzanemdor for the potential treatment of cognitive impairment in disorders of NMDAR hypofunction.
Contribution of initial lymphatics to oral wound healing after tooth extraction
Authors: Virtej Anca , Marti Larissa , Wagner Marek , Wiig Helge , Xue Ying , Bletsa Athanasia , Berggreen Ellen 
Published: July 2024

AbstractLymphatics are involved in the resolution of inflammation and wound healing, but their role in the oral wound healing process after tooth extraction has never been investigated. We therefore sought to evaluate the healing process following the extraction of maxillary molars in two transgenic mouse models: K14‐VEGFR3‐Ig mice, which lack initial mucosal lymphatic vessels, and K14‐VEGFC mice, which have hyperplastic mucosal lymphatics. Maxillary molars were extracted from both transgenic mouse types and their corresponding wild‐type (WT) controls. Mucosal and alveolar bone healing were evaluated. A delayed epithelialization and bone regeneration were observed in K14‐VEGFR3‐Ig mice compared with their WT littermates. The hampered wound closure was accompanied by decreased levels of epidermal growth factor (EGF) and persistent inflammation, characterized by infiltrates of immune cells and elevated levels of pro‐inflammatory markers in the wounds. Hyperplastic mucosal lymphatics did not enhance the healing process after tooth extraction in K14‐VEGFC mice. The findings indicate that initial mucosal lymphatics play a major role in the initial phase of the oral wound healing process.
Incomplete resection of the intracranial electroencephalographic seizure onset zone is not associated with postsurgical outcomes
Authors: Gascoigne Sarah J. , Evans Nathan , Hall Gerard , Kozma Csaba , Panagiotopoulou Mariella , Schroeder Gabrielle M. , Simpson Callum , Thornton Christopher , Turner Frances , Woodhouse Heather , Blickwedel Jess , Chowdhury Fahmida A. , Diehl Beate , Duncan John S. , Faulder Ryan , Thomas Rhys H. , Wilson Kevin , Taylor Peter N. , Wang Yujiang 
Published: July 2024

AbstractDelineation of seizure onset regions using intracranial electroencephalography (icEEG) is vital in the surgical workup of drug‐resistant epilepsy cases. However, it is unknown whether the complete resection of these regions is necessary for seizure freedom, or whether postsurgical seizure recurrence can be attributed to the incomplete removal of seizure onset regions. To address this gap, we retrospectively analyzed icEEG recordings from 63 subjects, identifying seizure onset regions visually and algorithmically. We assessed onset region resection and correlated this with postsurgical seizure control. The majority of subjects had more than half of their onset regions resected (82.46% and 80.65% of subjects using visual and algorithmic methods, respectively). There was no association between the proportion of the seizure onset zone (SOZ) that was subsequently resected and better surgical outcomes (area under the receiver operating characteristic curve [AUC] < .7). Investigating the spatial extent of onset regions, we found no substantial evidence of an association with postsurgical seizure control (all AUC < .7). Although seizure onset regions are typically resected completely or in large part, incomplete resection is not associated with worse postsurgical outcomes. We conclude that postsurgical seizure recurrence cannot be attributed to an incomplete resection of the icEEG SOZ alone. Other network mechanisms beyond icEEG seizure onset likely contribute.
The impact of involuntary job displacement on participation in gig work: A causal analysis
Authors: Jeon Sung‐Hee , Ostrovsky Yuri 
Published: July 2024

AbstractWe used rich Canadian administrative data linked to census records to examine the impact of firm closures and involuntary job displacement on entry into gig work. Similar to several recent studies, we identified gig workers as unincorporated self‐employed freelancers, independent consultants and on‐demand workers. We found that individuals displaced from closing firms are about 24% (1.1 p.p.) more likely to be gig workers in the year following the displacement year than the control group. We show that displaced workers remain strongly attached to traditional employment, and those who take up gig work often combine it with earning wages and salaries.
The independent and combined effects of physical activity and depressive symptoms on frailty in community‐dwelling older adults: A cross‐sectional study
Authors: Yang Lingli , Xue Benli , Zheng Xiao , Zhang Xinyi , Xiao Shujuan , Zhou Chunlan , Zhang Chichen 
Published: July 2024

AbstractAimsTo investigate the independent and combined effects of physical activity (PA) and depressive symptoms on the risk of frailty in community‐dwelling older adults.BackgroundOlder adults face a high risk of frailty which is commonly used to predict adverse health outcomes in older patients. Engaging in PA and without depressive symptoms are crucial factors to prevent frailty. It is essential to investigate the independent and combined effects of these two variables on the risk of frailty.MethodsWe included 3392 community‐dwelling older adults. The FRAIL Scale was used to assess older adults' frail status (robust, prefrail and frail). Multiple logistic regression was utilized to examine the independent and combined effects of PA and depressive symptoms on the risk of prefrailty and frailty. The combined effects were visualized by marginal plots.ResultsThe prevalence of prefrailty and frailty in older adults were 42.16% and 10.58%. Compared with the group of “Light physical activity and With depressive symptoms”, “Vigorous physical activity and Without depressive symptoms” had the lowest risk of prefrailty and frailty.ConclusionsOlder adults who do not engage in PA or have depressive symptoms increased the risk of frailty, but older adults with depressive symptoms could lower the risk of frailty through PA.Relevance to Clinical PracticeIt is effective to reduce the risk of frailty by directing older adults to do moderate physical activity, although they have depressive symptoms. The focus should also be on older adults with depressive symptoms, who have at least more than twice and fourfold risk of prefrailty and frailty compared to those without.ImpactThis study offers insights for future interventions aimed at preventing frailty in older adults.Reporting MethodThis study adhered to the STROBE checklist.Patient or Public ContributionsOlder adults participated in this study and completed questionnaires.
Investigating the impact of asymmetric macular sensitivity on visual acuity chart reading in choroideremia
Authors: Baffour‐Awuah Kwame A. , Taylor Laura J. , Josan Amandeep S. , Jolly Jasleen K. , MacLaren Robert E. 
Published: July 2024

AbstractIntroductionDegeneration in choroideremia, unlike typical centripetal photoreceptor degenerations, is centred temporal to the fovea. Once the fovea is affected, the nasal visual field (temporal retina) is relatively spared, and the preferred retinal locus shifts temporally. Therefore, when reading left to right, only the right eye reads into a scotoma. We investigate how this unique property affects the ability to read an eye chart.MethodsStandard‐ and low‐luminance visual acuity (VA) for right and left eyes were measured with the Early Treatment of Diabetic Retinopathy Study (ETDRS) chart. Letters in each line were labelled by column position. The numbers of letter errors for each position across the whole chart were summed to produce total column error scores for each participant. Macular sensitivity was assessed using microperimetry. Central sensitivity asymmetry was determined by the temporal‐versus‐nasal central macular difference and subsequently correlated to a weighted ETDRS column error score. Healthy volunteers and participants with X‐linked retinitis pigmentosa GTPase regulator associated retinitis pigmentosa (RPGR‐RP) were used as controls.ResultsThirty‐nine choroideremia participants (median age 44.9 years [IQR 35.7–53.5]), 23 RPGR‐RP participants (median age 30.8 years [IQR 26.5–40.5]) and 35 healthy controls (median age 23.8 years [IQR 20.3–29.0]) were examined. In choroideremia, standard VA in the right eye showed significantly greater ETDRS column errors on the temporal side compared with the nasal side (p = 0.002). This significantly correlated with greater asymmetry in temporal‐versus‐nasal central macular sensitivity (p = 0.04). No significant patterns in ETDRS column errors or central macular sensitivity were seen in the choroideremia left eyes, nor in RPGR‐RP and control eyes.ConclusionDifficulty in tracking across lines during ETDRS VA testing may cause excess errors independent of true VA. VA assessment with single‐letter optotype systems may be more suitable, particularly for patients with choroideremia, and potentially other retinal diseases with asymmetric central macular sensitivity or large central scotomas including geographic atrophy.
A retrospective comparison of IgE‐mediated cow's milk protein allergy management strategies in pediatric cohorts
Authors: Trujillo Juan , Cronin Caoimhe , Heng Tessa Ah , Flores Laura , McGinley Anne Marie , Gallagher Aoife , Muñoz Cristina , Velasco Roberto , Hourihane Jonathan 
Published: July 2024

AbstractBackgroundComplete avoidance of milk is the usual management for IgE‐mediated cow's milk protein allergy (CMPA). A baked milk ladder is a method of dietary advancement therapy in IgE‐mediated CMPA in Ireland, while in Spain, avoidance of milk awaiting natural tolerance acquisition through an oral food challenge (OFC) is employed. The aim of this study was to evaluate the use of dietary advancement therapy using a milk ladder compared with complete avoidance of milk for managing IgE‐mediated CMPA.MethodsThis is a retrospective chart review of 371 pediatric patients from the population who have been treated for IgE‐mediated CMPA between 2011 and 2020, with the milk ladder (Ireland) or complete avoidance followed by an OFC (Spain). The main outcome was the introduction of cow's milk.ResultsMilk ladder patients were 3.67 times more likely to succeed in comparison with milk avoidance (p < .001). Anaphylaxis during the treatment period occurred in 34 patients in the milk avoidance groups, while three patients in the milk ladder group experienced anaphylaxis due to accidental exposure to milk (p < .001). Failure to complete treatment was associated with a higher skin prick test in the milk avoidance group and a raised specific IgE in the milk ladder group.ConclusionThis is the first study that compares outcomes of dietary advancement therapy to complete avoidance for CMPA management, demonstrating that cow's milk can be successfully and safely reintroduced using dietary advancement therapy using a milk ladder.
Genital calcinosis cutis: Microscopic evidence supporting a dystrophic origin
Authors: Crockett Jessica L. , Copp Hillary L. , Mully Thaddeus W. , Francois Rony A. , Cordoro Kelly M. 
Published: July 2024

AbstractCalcinosis cutis (CC) is characterized by the deposition of calcium salts in the skin and subcutaneous tissues. CC involving the vulva or foreskin (prepuce) is uncommon. We present a 9‐year‐old female with vulvar CC and a 15‐year‐old male with preputial CC. Microscopic review of excisional specimens revealed calcification associated with follicular cysts in the vulvar case and lichen sclerosus in the preputial case, suggesting a dystrophic origin to a subset of cases of genital CC that might otherwise be classified as idiopathic. The clinical implication of these findings is the need for close histopathologic scrutiny and ongoing clinical surveillance of patients with genital CC initially deemed idiopathic.
Effects of transcranial direct current stimulation on different cognitive domains in Alzheimer's disease: a meta‐study
Authors: Li Xintong , Dou Yue , Xiao Bin , Chen Yuming 
Published: July 2024

AbstractBackgroundNumerous studies have investigated the potential effects of transcranial direct current stimulation (tDCS) on improving symptoms related to Alzheimer's disease (AD). However, these studies have produced inconsistent results, leading to a need for further investigation.MethodsA comprehensive search was conducted, including articles published from the initial availability date to 5 April 2024. The extracted study data were analyzed using STATA 12.0 software. The standard mean difference (SMD) and a 95% confidence interval (CI) were calculated to assess the effects of tDCS.ResultsA total of 18 studies assessing the effects of tDCS on AD were included in the study. The study revealed that tDCS has an immediate positive impact on general cognitive, executive, language, and visuospatial function. However, the study did not observe any other significant effect of tDCS treatment on improvements in brain function, including long‐term effects on general cognitive, attention, language, and memory function, as well as immediate effects on attention and memory function.ConclusionsIn conclusion, the study suggests that tDCS may be a promising intervention for improving the cognitive function of patients with AD. However, given the complex and multifactorial nature of AD, further well‐designed studies with larger sample sizes are necessary to clarify the effectiveness of tDCS and determine the optimal combination of tDCS parameters.
Advances in mass spectrometry imaging for plant metabolomics—Expanding the analytical toolbox
Authors: Yin Zhibin , Huang Wenjie , Li Kun , Fernie Alisdair R. , Yan Shijuan 
Published: July 2024

SUMMARYMass spectrometry imaging (MSI) has become increasingly popular in plant science due to its ability to characterize complex chemical, spatial, and temporal aspects of plant metabolism. Over the past decade, as the emerging and unique features of various MSI techniques have continued to support new discoveries in studies of plant metabolism closely associated with various aspects of plant function and physiology, spatial metabolomics based on MSI techniques has positioned it at the forefront of plant metabolic studies, providing the opportunity for far higher resolution than was previously available. Despite these efforts, profound challenges at the levels of spatial resolution, sensitivity, quantitative ability, chemical confidence, isomer discrimination, and spatial multi‐omics integration, undoubtedly remain. In this Perspective, we provide a contemporary overview of the emergent MSI techniques widely used in the plant sciences, with particular emphasis on recent advances in methodological breakthroughs. Having established the detailed context of MSI, we outline both the golden opportunities and key challenges currently facing plant metabolomics, presenting our vision as to how the enormous potential of MSI technologies will contribute to progress in plant science in the coming years.