bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Evidence-Based Systematic Review of Amplitude Compression in Hearing Aids for School-Age Children With Hearing Loss
Authors: McCreery Ryan W. , Venediktov Rebecca A. , Coleman Jaumeiko J. , Leech Hillary M. 
Published: December 2012

PurposeTwo clinical questions were developed: one addressing the comparison of linear amplification with compression limiting to linear amplification with peak clipping, and the second comparing wide dynamic range compression with linear amplification for outcomes of audibility, speech recognition, speech and language, and self- or parent report in children with hearing loss.MethodTwenty-six databases were systematically searched for studies addressing a clinical question and meeting all inclusion criteria. Studies were evaluated for methodological quality, and effect sizes were reported or calculated when possible.ResultsThe literature search resulted in the inclusion of 8 studies. All 8 studies included comparisons of wide dynamic range compression to linear amplification, and 2 of the 8 studies provided comparisons of compression limiting versus peak clipping.ConclusionsModerate evidence from the included studies demonstrated that audibility was improved and speech recognition was either maintained or improved with wide dynamic range compression as compared with linear amplification. No significant differences were observed between compression limiting and peak clipping on outcomes (i.e., speech recognition and self-/parent report) reported across the 2 studies. Preference ratings appear to be influenced by participant characteristics and environmental factors. Further research is needed before conclusions can confidently be drawn.
Hearing Technology and Cognition
Authors: Kalluri Sridhar , Humes Larry E. 
Published: December 2012

Purpose
To summarize existing data on the interactions of cognitive function and hearing technology in older adults.

Method
A narrative review was used to summarize previous data for the short-term interactions of cognition and hearing technology on measured outcomes. For long-term outcomes, typically for 3–24 months of hearing aid use, a computerized database search was conducted.

Results
There is accumulating evidence that cognitive function can impact outcomes following immediate or short-term use of hearing aids and that hearing aids can impact immediate cognitive function. There is limited evidence regarding the long-term impact of hearing aids on cognition, and the most rigorous studies in this area have not observed a positive effect.

Conclusions
Although interactions have been observed between cognition and use of hearing aids for measures obtained following immediate or short-term usage of hearing technology, limited evidence is available following long-term usage, and that evidence that is available does not support an effect of hearing aids on cognitive function. More research is needed, however, including rigorous studies of older adults following longer periods of hearing aid usage.
ADAPT-NMR Enhancer: complete package for reduced dimensionality in protein NMR spectroscopy
Authors: Lee Woonghee , Bahrami Arash , Markley John L. 
Published: December 2012

Abstract
Summary: ADAPT-nuclear magnetic resonance (ADAPT-NMR) offers an automated approach to the concurrent acquisition and processing of protein NMR data with the goal of complete backbone and side chain assignments. What the approach lacks is a useful graphical interface for reviewing results and for searching for missing peaks that may have prevented assignments or led to incorrect assignments. Because most of the data ADAPT-NMR collects are 2D tilted planes used to find peaks in 3D spectra, it would be helpful to have a tool that reconstructs the 3D spectra. The software package reported here, ADAPT-NMR Enhancer, supports the visualization of both 2D tilted planes and reconstructed 3D peaks on each tilted plane. ADAPT-NMR Enhancer can be used interactively with ADAPT-NMR to automatically assign selected peaks, or it can be used to produce PINE-SPARKY-like graphical dialogs that support atom-by-atom and peak-by-peak assignment strategies. Results can be exported in various formats, including XEASY proton file (.prot), PINE pre-assignment file (.str), PINE probabilistic output file, SPARKY peak list file (.list) and TALOS+ input file (.tab). As an example, we show how ADAPT-NMR Enhancer was used to extend the automated data collection and assignment results for the protein Aedes aegypti sterol carrier protein 2.
Availability: The program, in the form of binary code along with tutorials and reference manuals, is available at http://pine.nmrfam.wisc.edu/adapt-nmr-enhancer.
Contact: whlee@nmrfam.wisc.edu or markley@nmrfam.wisc.edu
Effect of bucindolol on heart failure outcomes and heart rate response in patients with reduced ejection fraction heart failure and atrial fibrillation
Authors: Kao David P. , Davis Gordon , Aleong Ryan , O'Connor Christopher M. , Fiuzat Mona , Carson Peter E. , Anand Inder S. , Plehn Jonathan F. , Gottlieb Stephen S. , Silver Marc A. , Lindenfeld JoAnn , Miller Alan B. , White Michel , Murphy Guinevere A. , Sauer Will , Bristow Michael R. 
Published: December 2012

AimsThere is little evidence of beta‐blocker treatment benefit in patients with heart failure and reduced left ventricular ejection fraction (HFREF) and atrial fibrillation (AF). We investigated the effects of bucindolol in HFREF patients with AF enrolled in the Beta‐blocker Evaluation of Survival Trial (BEST).Methods and resultsA post‐hoc analysis of patients in BEST with and without AF was performed to estimate the effect of bucindolol on mortality and hospitalization. Patients were also evaluated for treatment effects on heart rate and the influence of beta1‐adrenergic receptor position 389 (β1389) arginine (Arg) vs. glycine (Gly) genotypes. In the 303/2708 patients in AF, patients receiving bucindolol were more likely to achieve a resting heart rate ≤80 b.p.m. at 3 months (P < 0.005) in the absence of treatment‐limiting bradycardia. In AF patients and sinus rhythm (SR) patients who achieved a resting heart rate ≤80 b.p.m., there were beneficial treatment effects on cardiovascular mortality/cardiovascular hospitalization [hazard ratio (HR) 0.61, P = 0.025, and 0.79, P = 0.002]. Without achieving a resting heart rate ≤80 b.p.m., there were no treatment effects on events in either group. β1389‐Arg/Arg AF patients had nominally significant reductions in all‐cause mortality/HF hospitalization and cardiovascular mortality/hospitalization with bucindolol (HR 0.23, P = 0.037 and 0.28, P = 0.039), whereas Gly carriers did not. There was no evidence of diminished heart rate response in β1389‐Arg homozygotes.ConclusionIn HFREF patients with AF, bucindolol was associated with reductions in composite HF endpoints in those who achieved a resting heart rate ≤80 b.p.m. and nominally in those with the β1389‐Arg homozygous genotype.
Urinary kidney injury molecule 1 and incidence of heart failure in elderly men
Authors: Carlsson Axel C. , Larsson Anders , Helmersson‐Karlqvist Johanna , Lind Lars , Ingelsson Erik , Larsson Tobias E. , Sundström Johan , Ärnlöv Johan 
Published: December 2012

AimsThere is growing recognition of the clinical importance of cardiorenal syndrome—the bidirectional interplay between kidney and cardiac dysfunction. Yet, the role of kidney tubular damage in the development of heart failure is less studied. The objective of this study was to investigate whether urinary kidney injury molecule (KIM)‐1, a specific marker of tubular damage, predisposes to an increased heart failure risk.Methods and resultsThis was a community‐based cohort study [Uppsala Longitudinal study of Adult Men (ULSAM)] of 565, 77‐year‐old men free from heart failure at baseline. Heart failure hospitalizations were used as outcome. During follow‐up (median 8.0 years), 73 participants were hospitalized for heart failure. In models adjusted for cardiovascular risk factors (age, systolic blood pressure, diabetes, smoking, body mass index, LDL/HDL ratio, antihypertensive treatment, lipid‐lowering treatment, aspirin treatment, LV hypertrophy, and prevalent cardiovascular disease) and markers of kidney dysfunction and damage [cystatin C‐based glomerular filtration rate (GFR) and urinary albumin/creatinine ratio], a higher urinary KIM‐1/creatinine ratio was associated with higher risk for heart failure (hazard ratio upper vs. lower tertile, 1.81; 95% confidence interval 1.01–3.29; P < 0.05). Participants with a combination of low GFR (<60 mL/min/1.72 m2) and high KIM‐1/creatinine (>128 ng/mmol) had a 3‐fold increase in heart failure risk compared with participants with normal GFR and KIM‐1 (P < 0.001).ConclusionOur findings suggest that kidney tubular damage predisposes to an increased risk for heart failure in the community. Further studies are needed to clarify the causal role of KIM‐1 in the development of heart failure, and to evaluate the clinical utility of urinary KIM‐1 measurements.
Review of integrated size-structured models for stock assessment of hard-to-age crustacean and mollusc species
Authors: Punt Andre E. , Huang TzuChuan , Maunder Mark N. 
Published: December 2012

Abstract
Punt, A. E., Huang, T., and Maunder, M. N. 2013. Review of integrated size-structured models for stock assessment of hard-to-age crustacean and mollusc species. – ICES Journal of Marine Science, 70:16–33. Crustaceans and molluscs such as crabs, rock lobsters, prawns, abalone, and oysters constitute large and valuable fisheries. However, assessments of these species are hampered because they cannot be production aged, in contrast to many teleosts. The major data sources for these species, in addition to catch and abundance index data, are the size compositions of the catches and of any fishery-independent indices. Assessments of such species have been conducted using age-based methods of stock assessment, as well as surplus production models. However, size-structured methods are now preferred because they can make full use of size-composition data, are able to integrate multiple sources of data, and produce the types of outputs which are needed for management purposes. An advantage of size-based models over age-based models is that all processes can be size-based, and these processes can modify the (unmodelled) size-at-age distribution. We review these methods, highlighting the choices that need to be made when developing integrated size-structured stock assessments, the data sources which are typically available and how they are used for parameter estimation, and contrast a number of such assessments worldwide.
Genes expressed by the biological control bacterium Pseudomonas protegens Pf‐5 on seed surfaces under the control of the global regulators GacA and RpoS
Authors: Kidarsa Teresa A. , Shaffer Brenda T. , Goebel Neal C. , Roberts Daniel P. , Buyer Jeffrey S. , Johnson Aaron , Kobayashi Donald Y. , Zabriskie T. Mark , Paulsen Ian , Loper Joyce E. 
Published: December 2012

SummaryGene expression profiles of the biological control strain Pseudomonas protegens Pf‐5 inhabiting pea seed surfaces were revealed using a whole‐genome oligonucleotide microarray. We identified genes expressed by Pf‐5 under the control of two global regulators (GacA and RpoS) known to influence biological control and secondary metabolism. Transcript levels of 897 genes, including many with unknown functions as well as those for biofilm formation, cyclic diguanylate (c‐di‐GMP) signalling, iron homeostasis and secondary metabolism, were influenced by one or both regulators, providing evidence for expression of these genes by Pf‐5 on seed surfaces. Comparison of the GacA and RpoS transcriptomes defined for Pf‐5 grown on seed versus in broth culture overlapped, but most genes were regulated by GacA or RpoS under only one condition, likely due to differing levels of expression in the two conditions. We quantified secondary metabolites produced by Pf‐5 and gacA and rpoS mutants on seed and in culture, and found that production profiles corresponded generally with biosynthetic gene expression profiles. Future studies evaluating biological control mechanisms can now focus on genes expressed by Pf‐5 on seed surfaces, the habitat where the bacterium interacts with seed‐infecting pathogens to suppress seedling diseases.
DNA barcoding and the taxonomy of Microgastrinae wasps (Hymenoptera, Braconidae): impacts after 8 years and nearly 20 000 sequences
Authors: Alex Smith M. , Fernández‐Triana J. L. , Eveleigh E. , Gómez J. , Guclu C. , Hallwachs W. , Hebert P. D. N. , Hrcek J. , Huber J. T. , Janzen D. , Mason P. G. , Miller S. , Quicke D. L. J. , Rodriguez J. J. , Rougerie R. , Shaw M. R. , Várkonyi G. , Ward D. F. , Whitfield J. B. , Zaldívar‐Riverón A. 
Published: December 2012

AbstractMicrogastrine wasps are among the most species‐rich and numerous parasitoids of caterpillars (Lepidoptera). They are often host‐specific and thus are extensively used in biological control efforts and figure prominently in trophic webs. However, their extraordinary diversity coupled with the occurrence of many cryptic species produces a significant taxonomic impediment. We present and release the results of 8 years (2004–2011) of DNA barcoding microgastrine wasps. Currently they are the best represented group of parasitoid Hymenoptera in the Barcode of Life Data System (BOLD), a massive barcode storage and analysis data management site for the International Barcoding of Life (iBOL) program. There are records from more than 20 000 specimens from 75 countries, including 50 genera (90% of the known total) and more than 1700 species (as indicated by Barcode Index Numbers and 2% MOTU). We briefly discuss the importance of this DNA data set and its collateral information for future research in: (1) discovery of cryptic species and description of new taxa; (2) estimating species numbers in biodiversity inventories; (3) clarification of generic boundaries; (4) biological control programmes; (5) molecular studies of host‐parasitoid biology and ecology; (6) evaluation of shifts in species distribution and phenology; and (7) fostering collaboration at national, regional and world levels. The integration of DNA barcoding with traditional morphology‐based taxonomy, host records, and other data has substantially improved the accuracy of microgastrine wasp identifications and will significantly accelerate further studies on this group of parasitoids.
Patient perspectives on informed consent for anaesthesia and surgery: American attitudes
Authors: BURKLE C. M. , PASTERNAK J. J. , ARMSTRONG M. H. , KEEGAN M. T. 
Published: December 2012

BackgroundPrinciples of informed consent are ethically, morally, and legally grounded in physicians' responsibility to patients. This study examined patient expectations regarding the informed consent during the perioperative process, specifically risk information exchange, preferred method and timing of delivery, and the roles that patient anxiety and understanding might play.MethodsFive hundred patients seen in our pre‐operative clinic were surveyed by written questionnaire. Patients were asked about their level of agreement with a number of statements pertaining to informed consent and their preferences for discussion of types of risks. Anxiety concerns, impact of ability to understand complexities of care, preferences for timing, and method of presentation were assessed.ResultsFour hundred eleven of 500 surveys (82%) were completed. A majority of respondents (92% and 80%, respectively) believed the risk of common but less consequential complications and rare yet severe complications should be discussed. Only 21% agreed that anxiety generated by discussion of risks outweighed benefit and only 6% agreed that discussion of risks should be restricted based on patient inability to appreciate complexities of care. Discussion was preferred on the day of surgery, 1 week before, and 1 month before in 46%, 35%, and 16% of respondents, respectively, and independent of level of anxiety generated by such discussion (P = 0.87). Respondents preferred discussion with their anaesthesia provider alone (44%) or in combination with written information (52%) as compared with written information only (4%) (P < 0.01).ConclusionsGreater awareness of patient preferences and expectations may result in better information exchange between anaesthesia providers and their patients.
A randomized controlled trial of a smoking cessation intervention conducted among prisoners
Authors: Richmond Robyn , Indig Devon , Butler Tony , Wilhelm Kay , Archer Vicki , Wodak Alex 
Published: December 2012

AbstractAimTo evaluate the efficacy of nortriptyline (NOR) added to a multi‐component smoking cessation intervention, which included cognitive–behavioural therapy (CBT) and provision of nicotine replacement therapy (NRT).DesignRandomized controlled trial (RCT) comparing two study groups with blinded follow‐up at 3, 6 and 12 months. Both groups received a multi‐component smoking cessation intervention comprising two half‐hour individual sessions of CBT and NRT with either active NOR or placebo.SettingPrisons in New South Wales (17) and Queensland (one), Australia.ParticipantsA total of 425 male prisoners met inclusion criteria and were allocated to either treatment (n = 206) or control group (n = 219).MeasurementsPrimary end‐points at 3, 6 and 12 months were continuous abstinence, point prevalence abstinence and reporting a 50% reduction in smoking. Smoking status was confirmed by expired carbon monoxide, using a cut‐point of ≤10 parts per million.FindingsParticipants' demographics and baseline tobacco use were similar in treatment and control groups. Based on an intention‐to‐treat analysis, continuous abstinence between the treatment and control groups was not significantly different at 3 months (23.8 versus 16.4%), 6 months (17.5 versus 12.3%) and 12 months (11.7 versus 11.9%).ConclusionAdding nortriptyline to a smoking cessation treatment package consisting of behavioural support and nicotine replacement therapy does not appear to improve long‐term abstinence rates in male prisoners.
The micturition switch and its forebrain influences
Authors: Griffiths D. J. , Fowler C. J. 
Published: December 2012

AbstractDr DeGroat and Wickens has reviewed the central neural mechanisms controlling the lower urinary tract with a major focus on the brain stem circuitry that mediates the switch‐like characteristics of micturition, in particular the periaqueductal grey and the pontine micturition centre (de 2012). The review culminates in a computer model of how the brainstem switch operates in animals in which forebrain influences on micturition have been removed by decerebration. In this complementary paper, we review the mechanisms of forebrain involvement in the voluntary control of human micturition and the maintenance of continence with evidence based heavily on the results of functional brain imaging experiments.
Urinary incontinence in Alzheimer's disease is associated with Clinical Dementia Rating‐Sum of Boxes and Barthel Activities of Daily Living
Authors: Na Hae Ri , Park Moon Ho , Cho Sung Tae , Lee Byung Chul , Park Suyeol , Kim Khae Hawn , Choi Jong Bo 
Published: December 2012

AbstractIntroductionUrinary incontinence (UI) and Alzheimer's disease (AD) are common in the elderly population and have increased rapidly in recent decades. This study aimed to evaluate the prevalence of UI and determine the neuropsychological characteristics of patients with AD and UI.MethodsA total of 464 patients with probable AD were recruited, and the prevalence and type of UI were evaluated. Neuropsychological evaluation was assessed using the Mini‐Mental Status Examination, Clinical Dementia Rating, Clinical Dementia Rating‐Sum of Boxes, Global Deterioration Scale, Barthel Activities of Daily Living and Instrumental Activities of Daily Living.ResultsThe prevalence of UI in patients with AD was 24.8% (men 29.6%, women 23.0%). The two most common types of UI were urge incontinence (44.3%) and functional incontinence (25.3%). UI in patients with Alzheimer's disease was statistically significantly associated with Clinical Dementia Rating‐Sum of Boxes (OR 1.56, 95% CI 1.21–2.01) and Barthel Activities of Daily Living (OR 1.34, 95%CI 1.22–1.47) after adjustment for different covariates.DiscussionUI commonly occurred in patients with AD. The Clinical Dementia Rating‐Sum of Boxes and Barthel Activities of Daily Living could be potential predictors for UI in patients with AD.
Two‐weekly dose‐adjusted (DA)‐EPOCH‐like chemotherapy with high‐dose dexamethasone plus rituximab (DA‐EDOCH14‐R) in poor‐prognostic untreated diffuse large B‐cell lymphoma
Authors: García‐Suárez Julio , Flores Elena , Callejas Marta , Arribas Ignacio , Gil‐Fernández Juan‐José , Olmedilla Gabriel , Curto Natalia , Guillén Helga , Casco Celia‐Rosalva , Martín Yolanda , Burgaleta Carmen 
Published: December 2012

SummaryThe activity and safety of two‐weekly dose‐adjusted (DA)‐EPOCH (etoposide, prednisone, vincristine, cyclophosphamide, doxorubicin)‐like chemotherapy with high‐dose dexamethasone plus rituximab (DA‐EDOCH14‐R) was explored in 20 patients with previously untreated poor prognosis diffuse large B‐cell lymphoma (DLBCL). The main outcomes were compared with those of 27 poor‐prognosis patients enrolled into a previous trial of 3‐weekly DA‐EPOCH‐R. Toxicity was manageable and there were no therapy‐related deaths. Three‐year progression‐free survival (PFS) was superior in the DA‐EDOCH14‐R group (95% vs. 74%, P = 0·08). Importantly, this improvement in PFS with the two‐weekly DA‐EDOCH14‐R was particularly notable in patients with an age‐adjusted International Prognostic Index of 3 (100% vs. 30%, P < 0·001).
Electroacupuncture Suppresses Mechanical Allodynia and Nuclear Factor Kappa B Signaling in Streptozotocin‐Induced Diabetic Rats
Authors: Shi Lei , Zhang Hong‐Hong , Xiao Ying , Hu Ji , Xu Guang‐Yin 
Published: December 2012

SummaryAimsTo investigate whether electroacupuncture (EA) produced analgesic effect and whether nuclear factor kappa B (NF‐κB) and cystathionine β synthase (CBS) involved in EA‐mediated analgesia in painful diabetic neuropathy in rats.MethodsDiabetes was induced by an intraperitoneal injection of streptozotocin (STZ) in adult female rats. Mechanical pain threshold was measured by von Frey filaments. EA was applied at acupoint Zu‐San‐Li (ST‐36) in both hindlimbs. Western blot analysis was employed to detect changes in protein levels of NF‐κB and CBS in spinal dorsal root ganglion (DRGs).ResultsMechanical allodynia was developed 2 weeks after STZ injection and lasted for another 4 weeks. STZ injection significantly enhanced expression of p65 and CBS in lumbar L4‐6 DRGs when compared with age‐matched controls. EA markedly attenuated mechanical allodynia. Importantly, EA treatment remarkably inhibited p65 and CBS expression in DRGs. Additionally, intrathecal injection of the p65 antagonist pyrrolidine dithiocarbamate attenuated mechanical allodynia and markedly inhibited CBS expression in DRGs in STZ rats.ConclusionsThese data indicate that EA produced an analgesic effect, which might be mediated at least in a part by inhibition of NF‐κB signaling pathway in primary sensory neurons in rats with diabetes.