bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Lung Cancer Screening at an Academic Medical Center
Authors: Cantu Cynthia , Jones Rebecca , Garcia Dolores , Reyes Arlene , Cancino Ramon S. 
Published: August 2024

ABSTRACT

Introduction:
Lung cancer ranks as the third most prevalent cancer in the United States. The use of low-dose computed tomography (LDCT) screening significantly reduces mortality from this disease. Unfortunately, Texas lags in completing lung cancer screening (LCS) for high-risk patients, ranking 48th among all states. It is crucial to implement quality improvement (QI) initiatives in Texas. In collaboration with the American Cancer Society, the primary care center (PCC) at our institution led a multidisciplinary QI project aimed at enhancing LCS through LDCT for eligible PCC patients.

Methods:
The study included patients eligible for screening and who fall into the following categories: established patients with Medicaid, low-income or uninsured established patients, and established patients with either Medicare or commercial insurance. Enhancements to electronic medical records, education for clinical staff and patients, and a coordinated, multidisciplinary effort were implemented.

Results:
The study revealed a substantial 40.2% improvement in LCS rates.

Conclusion:
The US Preventive Services Task Force guidelines rely on an accurate history of patient's tobacco use to identify patients eligible for LCS. This QI project achieved success in improving the thoroughness of tobacco use history documentation and surpassed our target for increasing LCS by more than 10%.
Progression of Chest X-ray Findings of Silicosis Among Fluorspar Miners and Prognostic Factors
Authors: Khishigtogtokh Davaajav , Bayasgalan Nasanjargal , Lkhachinbal Munkhtsetseg , Dashtseren Ichinnorov , Nishikawa Yoshitaka , Toyama Mayumi , Takahashi Yoshimitsu , Nakayama Takeo 
Published: August 2024

Objective
This study aimed to delineate the natural progression of silicosis in fluorspar miners after the termination of dust exposure and identify its prognostic factors.

Methods
This retrospective cohort study, conducted from 2000 to 2019, included 67 former miners. Radiological images were evaluated by comparing the initial and most recent radiographs using the International Classification of Radiographs of Pneumoconiosis. Cox multivariate proportional hazard models were used to estimate the hazard ratios using follow-up time to analyze the multivariable study of associated prognostic factors.

Results
Among the participants, 50 (75%) exhibited progression over 2 to 16 years (median, 5.8 years). The Cox analysis highlighted older age as a likely precursor to the progression of significant opacities. Additionally, higher International Labour Organization category grades at onset were associated with disease progression.

Conclusions
Nearly three-quarters of the miners diagnosed with silicosis demonstrated radiological progression even after the termination of dust exposure. Advancement in age and the degree of initial radiological opacity were associated with progression.
A Retrospective Chart Review of Factors That Influence Outpatient Physical Therapy Care for Individuals With Chronic Constipation Utilizing an Intersectionality Lens
Authors: Wood Andrea , Rodriguez Joselyn , Manderson Lottoya Janiel , Yusufova Rena , Ahn Soyeon , Cahalin Lawrence P. 
Published: August 2024

Purpose:
This study sought to investigate intersectional factors regarding race, gender, health status, barriers to care, and socioeconomic factors surrounding adult individuals referred to outpatient physical therapy care with chronic constipation in the Miami, Florida metro area.

Methods:
The study was a retrospective chart review of 200 individuals referred to outpatient physical therapy at the University of Miami Health System over five years. The four primary questions that sought to explain physical therapy wait times, distance driven for care, duration of constipation on initial evaluation, and subjective well-being on the last physical therapy appointment were analyzed through binary logistic regression.

Results:
Our results demonstrate that subjective well-being at the end of outpatient physical therapy care for chronic constipation was negatively affected by identifying as African American/Black versus Caucasian (77.3%, odds ratio = 0.227 95% confidence interval, 0.061-0.847) and high durations of constipation ≥5 years (86.4%, odds ratio = 0.136; 95% confidence interval, = 0.026-0.723). Additionally, subjective well-being at the end of physical therapy care for CC was positively affected by an increasing number of sessions (9%, OR = 1.09; 95% CI, 1.002-1.194).

Conclusion:
Our findings indicated race and duration of constipation may impact clinical outcomes for individuals seeking outpatient physical therapy care for chronic constipation. Descriptive statistics also demonstrate the need to reach individuals with chronic constipation sooner and call for a more equitable and diverse representation of individuals in chronic constipation research and clinical care.
Splicing of Helix Framework in Modified Nagata Method Stage I for Auricle Reconstruction in Patients With Insufficient 8th Rib Cartilage
Authors: Qian Jin , Lu Peng , He Bei , Liu Tun 
Published: August 2024

Background
The 8th rib cartilage was sometimes insufficient to construct a complete external helix in ear reconstruction for microtia. The aim of this study was to investigate the splicing technique of 8th rib cartilage in modified Nagata method stage I.

Methods
Between September 2022 and May 2023, 231 consecutive patients with microtia underwent auricular reconstruction with modified Nagata method stage I. Thirty-four patients with insufficient 8th rib cartilage were screened out by three-dimensional (3D) computed tomography preoperatively, who were included in the study prospectively. The 8th rib was spliced to create the external helix when fabricating the ear framework in the stage I surgery for the 34 patients. The median duration of follow-up was 12.1 months (8–15 months).

Results
There were no perioperative complications in our study. During follow-up, all patients had satisfying outcomes, with no inward collapse, displacement, or absorption of the spliced external helix. The splicing point was not obvious.

Conclusions
It was safe and effective to splice the 8th rib cartilage for external helix of the cartilage framework in ear reconstruction for microtia.
Mapping the Research on Periocular Basal Cell Carcinoma in the Past 20 Years: A Bibliometric Network Analysis
Authors: Wang Minghui , Li Gongfei , Zhang Ju 
Published: August 2024

Purpose:
This study aims to analyze the literature on periocular basal cell carcinoma, identify research trends, and offer insights into future research areas in this field to assist clinicians and researchers.

Methods:
903 publications on periocular basal cell carcinoma were collected from the Web of Science Core Collection database. We assessed the contributions from various countries, institutions, journals, and authors, and performed network analysis using Excel, VOSviewer, and R Studio to represent the prominent areas of research visually.

Results:
The country with the highest number of publications and citations in this study was the United States of America, with 250 publications, 5917 citations, and the highest H-index of 44. Ophthalmic Plastic and Reconstructive Surgery is the leading journal. The UTMD Anderson Cancer Center had the highest number of publications, accounting for 43, or 4.76% of the total. Selva D from the University of Adelaide, Australia, is the top author with 26 publications, and 751 citations. Targeted therapy for PBCC-related pathways has been a hot topic in recent years.

Conclusions:
This study using bibliometrics seeks to explore the patterns and focal points of research and analyzes publication patterns, key research areas, influential authors, and prominent journals in periocular basal cell carcinoma during the last 2 decades.
Expression and Function of Connexin 43 and Connexin 37 in the Murine Zona Glomerulosa
Authors: Stölting Gabriel , Hellmig Nicole , Dinh Hoang An , Volkert Marina , Scholl Ute I. 
Published: August 2024

ABSTRACTThe zona glomerulosa (ZG) synthesizes the mineralocorticoid aldosterone. The primary role of aldosterone is the maintenance of volume and electrolyte homeostasis. Aldosterone synthesis is primarily regulated via tightly controlled oscillations in intracellular calcium levels in response to stimulation. It has previously been shown that calcium oscillations are synchronized through mechanical linkage between adjacent ZG cells. In many other cell types, similar synchronization is rather dependent on gap junctions (GJ). The recent discovery of mutations inCADM1was linked to impaired GJ function in the ZG. Based on published transcriptomics data, we re-examined the presence and functional impact of GJ in the ZG. We found evidence for the expression of connexin 43 and 37 in the ZG in microarray data, in-situ hybridization and immunohistology. Calcium oscillations in ZG rosettes showed some degree of synchronization as reported previously. Unspecific GJ inhibition only had a small impact on this synchronicity. However, no signs of connections between cytosols could be observed as indicated by the lack of fluorescence recovery after photobleaching. We conclude that, while connexin proteins are expressed in the ZG, functional GJ in the physiological ZG are rare and of little consequence for calcium signaling.
Single-cell integration and multi-modal profiling reveals phenotypes and spatial organization of neutrophils in colorectal cancer
Authors: Marteau Valentin , Nemati Niloofar , Handler Kristina , Raju Deeksha , Kirchmair Alexander , Rieder Dietmar , Soto Erika Kvalem , Fotakis Georgios , Carollo Sandro , Boeck Nina , Rossi Alessia , Scheiber Alexandra , Amann Arno , Seeber Andreas , Gasser Elisabeth , Ormanns Steffen , Günther Michael , Martowicz Agnieszka , Loncova Zuzana , Lamberti Giorgia , Krogsdam Anne , Carlet Michela , Horvath Lena , Eling Marie Theres , Fazilaty Hassan , Valenta Tomas , Sturm Gregor , Sopper Sieghart , Pircher Andreas , Stoitzner Patrizia , Wild Peter J. , Welker Patrick , May Pascal J. , Ziegler Paul , Tschurtschenthaler Markus , Neureiter Daniel , Huemer Florian , Greil Richard , Weiss Lukas , Ijsselsteijn Marieke , de Miranda Noel F.C.C. , Wolf Dominik , Arnold Isabelle C. , Salcher Stefan , Trajanoski Zlatko 
Published: August 2024

SUMMARYThe immune composition of the tumor microenvironment (TME) has a major impact on the therapeutic response and clinical outcome in patients with colorectal cancer (CRC). Here, we comprehensively characterize the TME at the single-cell level by first building a large-scale atlas that integrates 4.27 million single cells from 1,670 patient samples. We then complemented the atlas with single-cell profiles from four CRC cohorts with 266 patients, including cells with low mRNA content, spatial transcriptional profiles from 3.7 million cells, and protein profiles from 0.7 million cells. The analysis of the atlas allows refined tumor classification into four immune phenotypes: immune desert, B cell enriched, T cell enriched, and myeloid cell enriched subtypes. Within the myeloid compartment we uncover distinct subpopulations of neutrophils that acquire new functional properties in blood and in the TME, including anti-tumorigenic capabilities. Further, spatial multimodal single-cell profiling reveals that neutrophils are organized in clusters within distinct functional niches. Finally, using an orthotopic mouse model we show that cancer-derived systemic signals modify neutrophil production in the bone marrow, providing evidence for tumor-induced granulopoiesis. Our study provides a big data resource for the CRC and suggests novel therapeutic strategies targeting neutrophils.
Black Women and the Preemie Prep for Parents (P3) Program: Exploratory Analysis of a Clinical Trial
Authors: McDonnell Siobhan M , Flynn Kathryn E , Barnekow Kris , Kim U. Olivia , Brazauskas Ruta , Ahamed S. Iqbal , McIntosh Jennifer J , Pitt Michael B , Leuthner Steven R , Kruper Abbey , Basir Mir A 
Published: August 2024

AbstractBackgroundThe smartphone Preemie Prep for Parents (P3) program was developed to address the gap in prenatal education of preterm birth in high-risk pregnancies. Despite a higher incidence of preterm birth, Black women are less likely to receive prenatal education.MethodsPregnant women with medical conditions that predisposed them to preterm birth were randomized to receive the P3 program or links to American College of Obstetricians and Gynecologists webpages (control). The P3 group received periodic text messages, starting as early as 18 weeks gestational age, each with a link to a short, animated educational video. Participants completed the Parent Prematurity Knowledge Questionnaire, PROMIS Anxiety scale, and a feedback survey. This is a subgroup analysis of the Black, non-Hispanic participants in the P3 trial.ResultsOf the 26 Black non-Hispanic women enrolled, the P3 group (n=14) had higher knowledge scores than the control group (n=12), 67.5% correct vs. 43.6% (difference 24.0; 95% CI, 7.4 to 40.6), without experiencing an increase in anxiety. More P3 participants reported discussing preterm birth with their partner (100%) than control participants (57%; difference 43; 95% CI, 6 to 80).ConclusionsThe P3 program appears to be an effective method of providing preterm birth education to Black pregnant women.
The interaction of effective drivers in future religious tourism development in Yazd province as a global religious destination
Authors: Mirhoseini Atefeh , Nayebzadeh Shahnaz , Rousta Alireza 
Published: August 2024

Purpose
The geographical location of Yazd province has significant potential for religious tourism. To make the most of this opportunity, it is important to develop an interpretive structural modeling. This paper aims to outline a model for the development of religious tourism in Yazd province as a Global Religious Destination by identifying and analyzing the interaction of effective drivers in future religious tourism development.

Design/methodology/approach
The research methodology is based on the interpretative paradigm and is developmental in nature. It takes an exploratory-analytical approach through the adoption of an inductive method and uses mixed research (qualitative/quantitative) involving religious tourism experts and tourists. The study consists of three main steps. In the first step, effective drivers in future religious tourism development were identified through content analysis of published articles. In the second step, the identified drivers were finalized through a survey of experts. Using futures research and Micmac software, a model was designed to investigate the interaction of the future drivers of religious tourism development. In the third step of the research, 384 tourists who visited Yazd Global Religious Destination participated to check the accuracy of the presented model.

Findings
Content analysis and review of scientific documents have identified 14 effective drivers in future religious tourism development that have finalized in a layered model. The model identified factors from the most influential at level one to the least influential at level eight. the theoretical foundations of this research confirmed by 384 visitors participated.

Originality/value
developing religious tourism, whether in the form of a religious city, a religious value system, a religious ceremony and a religious business, requires a comprehensive view that includes tourist’s mental and visual imagery, destination brand’s ideals and visions, religious belief, governmental and formal activities and the material and spiritual capital that can offer religious life style in the world markets to audiences from all over the world in the best way and in the dynamic conditions of competition between destination brands, occupy the first rungs of the audience’s mental ladder.
Untangling the determinants of carbon management strategy adoption in an emerging economy
Authors: Bedi Ankita , Singh Balwinder 
Published: August 2024

Purpose
The current longitudinal study explores the determinants of carbon management strategy in an emerging economy.

Design/methodology/approach
The study is based on BSE 500 Indian firms for 7 years i.e. from 2016–17 to 2022–23. The appropriate panel regression models have been used to untangle the determinants of carbon management strategy.

Findings
The empirical findings of the study document that gender diversity, environment committee, Environment Management System (EMS) and climate change risks and opportunities play a significant and positive role in the adoption of carbon management strategy. Contrary, board size exerts a significant and negative influence on carbon management strategy adoption.

Practical implications
The study enriches the emerging climate change and carbon management strategy literature.

Social implications
The study provides treasured acumens to regulators, policymakers and managers as the study highlights the role of various determinants in carbon management strategy adoption.

Originality/value
The current research provides novel insights into carbon management strategy literature by unraveling the determinants of carbon management strategy adoption. Further, to the best of the authors’ knowledge, the present study is the first to explore the determinants of carbon management strategy adoption in a developing country context.
Inclusive tourism: applying critical approach to a Web of Science bibliometric review
Authors: Qiao Guanghui , Hou Songhe , Huang Xue , Jia Qiaoran 
Published: August 2024

Purpose
The purpose of this paper is to reveal the knowledge evolution process, research hotspots and future trends in the inclusive tourism research literature from 2008 to 2023.

Design/methodology/approach
A total of 322 papers on inclusive tourism were selected from the core collection database of Web of Science and analyzed using CiteSpace.

Findings
Over the 16-year period between 2008 and 2023 an increasing number of studies have been published concerning inclusive tourism, but the overall base is still small. Among institutions, the Massey University and University of Gothenburg take the lead in international research on inclusive tourism. Country cooperation shifted from UK-centered in 2008 to Australia, US and Spain from 2010, expanded to more nations and recently increased with China, Japan and others. The essence of inclusive tourism is inherently linked to societal and generational development, necessitating the elimination of social exclusion and inequality to achieve sustainability. The research on inclusive tourism has undergone three stages, emphasizing tourism producers, consumers and stakeholder relationships respectively. “Employment”, “sustainable development” and “quality of life” possess the potential to emerge as future research hotspots.

Originality/value
By combining literature on inclusive tourism and other overlapping concepts, CiteSpace was used to construct data and network visualizations, including a burst and dynamic analysis for the period covered by the sample. The conclusions offer researchers insights into the existing body of work in inclusive tourism research and suggest directions for future research. In practice, tourism managers can gain a deeper understanding of the needs and limitations of marginalized groups in tourism, allowing them to offer more tailored products for inclusive tourism and further enhance the development of an inclusive tourism environment.
Contrasting responses of naturalized alien and native plants to native soil biota and drought
Authors: Ruppert Hannah K. , van Kleunen Mark , Wilschut Rutger A. 
Published: August 2024

Abstract

Terrestrial plant communities often become invaded by alien species, which may benefit from high growth rates, strong phenotypic plasticity and reduced negative impacts from local soil communities. At the same time, terrestrial communities are increasingly more often exposed to periods of drought. However, how drought affects the competition between alien and native plants directly, and indirectly, through changing impacts of soil communities on plant performance, remains poorly understood.

Here, we performed a greenhouse pot experiment in which we examined biomass responses of five native and five naturalized alien species (all occurring in mesic grasslands) to drought and benign soil moisture conditions, while growing in interspecific, intraspecific or absence of competition, in the presence or absence of native soil biota. We expected that alien plant species are less negatively affected by soil biota, but more negatively affected by drought than native species, and that drought indirectly weakens soil‐community‐driven competitive benefits of alien plant species over native ones.

On average, soil‐community effects on plant biomass were positive, but native performance was less positively affected by soil communities than alien performance, suggesting reduced impacts of soil‐borne enemies on alien plants. Drought more negatively affected alien‐ than native plant performance. Drought impacts on plant biomass did not depend on soil community presence, but in the presence of soil biota, plants overall invested more in root biomass when exposed to drought. The effects of competition were subtle and species‐specific.

To better understand the observed positive soil‐community effects on plant performance in our study, we examined mycorrhizal root colonization of plants grown in absence of competition. Among‐species variation in mycorrhizal colonization explained plant performance differences between soils with and without live soil communities, indicating a key role for arbuscular mycorrhizal fungi as driver of plant performance. However, mycorrhizal colonization did not differ between alien and native plants and was unaffected by drought.

Overall, our study suggests that drought may weaken alien plant invasions through stronger direct negative impacts on alien than on native plant performance, but that drought does not affect soil‐biota‐driven differences in plant performance between alien and native plants.

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