bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resilience after severe critical illness: a prospective, multicentre, observational study (RESIREA)
Authors: Mathieu Alice , Reignier Jean , Le Gouge Amélie , Plantefeve Gaetan , Mira Jean-Paul , Argaud Laurent , Asfar Pierre , Badie Julio , Botoc Nicolae-Vlad , Bui Hoang-Nam , Chatellier Delphine , Chauvelot Louis , Cracco Christophe , Darmon Michael , Delbove Agathe , Devaquet Jérôme , Dumont Louis-Marie , Gontier Olivier , Groyer Samuel , Hourmant Yannick , Jaber Samir , Lambiotte Fabien , Madeux Benjamin , Maizel Julien , Martinet Olivier , Maxime Virginie , Mercier Emmanuelle , Nay Mai-Anh , Nseir Saad , Piton Gael , Quenot Jean-Pierre , Renault Anne , Rigaud Jean-Philippe , Schneider Francis , Sirodot Michel , Souweine Bertrand , Tamion Fabienne , Thévenin Didier , Thieulot-Rolin Nathalie , Tinturier Francois , Tirot Patrice , Vinatier Isabelle , Vinsonneau Christophe , Lascarrou Jean-Baptiste , Laurent Alexandra ,   the NUTRIREA-3 Trial Investigators,   the Clinical Research In Intensive Care and Sepsis (CRICS-TRIGGERSEP) Group
Published: July 2024

Abstract
Background
Critical-illness survivors may experience post-traumatic stress disorder (PTSD) and quality-of-life impairments. Resilience may protect against psychological trauma but has not been adequately studied after critical illness. We assessed resilience and its associations with PTSD and quality of life, and also identified factors associated with greater resilience.

Methods
This prospective, multicentre, study in patients recruited at 41 French ICUs was done in parallel with the NUTRIREA-3 trial in patients given mechanical ventilation and vasoactive amines for shock. Three months to one year after intensive-care-unit admission, survivors completed the Connor-Davidson Resilience Scale (CD-RISC-25), Impact of Event-Revised scale for PTSD symptoms (IES-R), SF-36 quality-of-life scale, Multidimensional Scale of Perceived Social Support (MSPSS), and Brief Illness Perception Questionnaire (B-IPQ).

Results
Of the 382 included patients, 203 (53.1%) had normal or high resilience (CD-RISC-25 ≥ 68). Of these resilient patients, 26 (12.8%) had moderate to severe PTSD symptoms (IES-R ≥ 24) vs. 45 (25.4%) patients with low resilience (p = 0.002). Resilient patients had higher SF-36 scores. Factors independently associated with higher CD-RISC-25 scores were higher MSPSS score indicating stronger social support (OR, 1.027; 95%CI 1.008–1.047; p = 0.005) and lower B-IPQ scores indicating a more threatening perception of the illness (OR, 0.973; 95%CI 0.950–0.996; p = 0.02).

Conclusions
Resilient patients had a lower prevalence of PTSD symptoms and higher quality of life scores, compared to patients with low resilience. Higher scores for social support and illness perception were independently associated with greater resilience. Thus, our findings suggest that interventions to strengthen social support and improve illness perception may help to improve resilience. Such interventions should be evaluated in trials with PTSD mitigation and quality-of-life improvement as the target outcomes.
A randomized controlled trial to assess if changing sleep timing can improve glucose metabolism in people with prediabetes and type 2 diabetes
Authors: Bouman Emma J. , Slebe Romy , Stenvers Dirk Jan , Elders Petra J. M. , Beulens Joline W. J. , Rutters Femke 
Published: July 2024

Abstract
Background
Social jetlag is a chronic disruption of sleep timing that is characterized by different sleep timing during workdays and free days. Social jetlag has been associated with disturbed glucose metabolism, insulin resistance, and increased risk of metabolic syndrome and type 2 diabetes. In this study, we aim to investigate whether a combination of bright light therapy in the morning, bright light reduction in the evening and sleep advance instructions for 3 weeks reduces social jetlag and if this results in improvement of glycemic and metabolic control, sleep, mood and quality of life after 3 and 12 weeks in people with prediabetes and type 2 diabetes and to assess possible mediators, compared to regular sleep habits.

Methods
In this randomized controlled trial, 60 people with prediabetes or type 2 diabetes with > 1 h social jetlag will be recruited. The intervention consists of bright light therapy (5000 lx) emitted by Vitamine-L (Lumie, UK) for 30 min each morning, combined with the advice to follow sleep advance instructions and to wear bright light-dimming goggles every evening for a period of 3 weeks. The control group adheres to their regular sleep habits and conditions. The primary outcome is glycated hemoglobin (HbA1c) after 12 weeks comparing the intervention and control in an intention-to-treat analysis. Secondary outcomes at 3 and 12 weeks are (1) social jetlag; (2) insulin sensitivity, fasting blood glucose, glucose-lowering medication use, and frequency of perceived hypoglycemia; (3) metabolic outcomes, including body mass index (BMI), waist circumference, body fat percentage, and blood pressure; (4) mood, including depression, fatigue and anxiety (measured with questionnaires); and (5) quality of life measured using EQ5D questionnaire. To assess other factors that might play a role as possible mediators, we will measure (para)sympathetic nervous system activity assessed with ECGs and electrochemical skin conductance tests, sleep quality and sleep phase distribution assessed with a sleep measuring headband (ZMax), the Dim Light Melatonin Onset in saliva samples (in a subgroup) at 3 and 12 weeks, the feeling of satiety and satiation with a 10-cm visual analog scale (VAS), diet using a food frequency questionnaire, and physical activity using an accelerometer (ActiGraph).

Discussion
Social jetlag can contribute to poorer glycemic control and metabolic control in those with type 2 diabetes. With this intervention, we aim to reduce social jetlag and thereby improve glycemic and metabolic control. This could offer a way to improve overall population health and to reduce the disease burden of type 2 diabetes.

Trial registration
ISRCTN registry ISRCTN11967109. Registered on 9 May 2024.
Bezold’s abscess, an uncommon complication of otitis media and cholesteatoma: a case report
Authors: Toloczko Alexandra J. , Davis Thomas S. , Issa Mayada H. 
Published: July 2024

Abstract
Background
Mastoiditis frequently occurs in children as they are more susceptible to middle ear infections, but infrequently occurs in adults. A rare complication that results from mastoiditis and an obstructing cholesteatoma is a Bezold’s abscess, of which there are less than 100 reported cases in literature to date.

Case presentation
Here, we present a case of a 72-year-old Caucasian man who has had no history of prior ear infections and was found to have a cholesteatoma and advanced acute coalescent mastoiditis complicated by a Bezold’s abscess.

Conclusions
Bezold’s abscess is a rare entity infrequently encountered in the modern era, likely owing to more prompt treatment of otitis media. Cholesteatoma poses a great risk for both the development of otitis media and further progression to mastoiditis and its associated complications, such as Bezold’s abscess. Knowledge of said abscess is crucial; without prompt recognition, further spread of infection can occur with vascular or mediastinal involvement.
Mucinous tubular and spindle renal cell carcinoma revealed by a trauma of the kidney: a case report
Authors: Chaker Kays , Marrak Mahdi , Gharbia Nader , Zehani Alia , Ouanes Yassine , Nouira Yassine 
Published: July 2024

Abstract
Background
Mucinous tubular and spindle cell carcinoma is a rare renal tumor. It has been recognized as a distinct entity in the 2004 World Health Organization tumor classification. Since then, several dozen of these tumor have been reported with additional complementary morphologic characteristics, immunohistochemical profile, and molecular genetic features that have further clarified its clinicopathologic aspects.

Case presentation
We report the case of a 52-year-old male African patient who was found to have a mucinous tubular and spindle renal cell carcinoma on a nephrectomy specimen for a severe kidney trauma.

Conclusions
This tumor has a histological spectrum ranging from low to high grade, which includes sarcomatoid differentiation that can confer the tumor an aggressive clinical course.
Untangling the corruption maze: exploring the complexity of corruption in the health sector
Authors: Sommersguter-Reichmann Margit , Reichmann Gerhard 
Published: July 2024

Abstract
Background
Healthcare corruption poses a significant threat to individuals, institutions, sectors, and states. Combating corruption is paramount for protecting patients, maintaining the healthcare system's integrity, and preserving public trust. As corruption evolves, takes new forms, and adapts to changing socio-political landscapes, understanding its manifestations is critical to developing effective anti-corruption strategies at individual and institutional levels.

Objective
The aim was to comprehensively collate the manifestations of different types of corruption in healthcare to illustrate prevailing patterns and trends and to provide policymakers, practitioners, and researchers with practical insights to inform research agendas, regulatory and governance strategies, and accountability measures.

Method
We conducted a narrative review of scientific articles published between 2013 and 2022 using keyword searches in SCOPUS and EBSCO. We utilized the corruption typology proposed by the European Union and Thompson's Institutional Corruption Framework to systematically identify manifestations across different corruption types. The Prisma scheme was employed to document the selection process and ensure reproducibility.

Findings
Bribery in medical service provision was the most frequently investigated form of corruption, revealing rather uniform manifestations. Misuse of high-level positions and networks and institutional corruption also received considerable attention, with a wide range of misconduct identified in institutional corruption. Extending the analysis to institutional corruption also deepened the understanding of misconduct in the context of improper marketing relations and highlighted the involvement of various stakeholders, including academia. The pandemic exacerbated the vulnerability of the healthcare sector to procurement corruption. Also, it fostered new types of misconduct related to the misuse of high-level positions and networks and fraud and embezzlement of medical drugs, devices, and services.

Conclusions
The review spotlights criminal actions by individuals and networks and marks a notable shift towards systemic misconduct within specific types of corruption. The findings highlight the necessity of customized anti-corruption strategies throughout the healthcare sector. These insights are crucial for policymakers, practitioners, and researchers in guiding the formulation of legal frameworks at local and global levels, governance strategies, and research priorities.
Current trends in forestry research of Latin-America: an editorial overview of the Special Issue
Authors: Martínez Pastur Guillermo J. , Roig Fidel A. 
Published: July 2024

AbstractMendoza city (Argentina) hosted the VIII Latin American Forestry Congress (CONFLAT) and the V Forestry Congress of Argentina (CFA) in 2023, where relevant issues were addressed, such as climate change, degradation, reforestation, management and forest industry, monitoring, environmental services, social issues, and governance, among others. The objective of this Special Issue was to present the main advances in Forestry Science for Latin-America in the context of changing governance and forest livelihoods for people. The fifteen articles emphasize the interdisciplinary nature of the forest management and conservation, and that multiple variables must be considered to achieve sustainability. The articles come from studies across Southern South-America (Argentina, Brazil, Chile, and Uruguay), and the collaboration of researchers of other countries (México, Canada, and Spain). Articles include research in tropical, Mediterranean and temperate Sub-Antarctic forests. Together, these articles provide a snapshot of new forestry research carried out locally and internationally to bring about beneficial ecological and environmental outcomes in a world facing the challenges of sustainable management and conservation amongst the threats and uncertainty of climate change and environmental degradation responsible for extensive loss of biodiversity and environmental services. We believe that this Special Issue will encourage more inter-disciplinary research focusing on management and conservation of forests.
Real-world efficacy of intravitreal faricimab for neovascular age-related macular degeneration: a systematic review
Authors: Nasimi Nasratullah , Nasimi Safiullah , Grauslund Jakob , Vergmann Anna Stage , Subhi Yousif 
Published: July 2024

Abstract
Background
To systematically review the real-world outcomes of intravitreal faricimab treatment in patients with neovascular age-related macular degeneration (nAMD) to evaluate its efficacy and safety in clinical settings. This study was conducted due to the need for real-world evidence to complement the findings from controlled clinical phase-III trials.

Methods
A systematic literature search was conducted on March 17, 2024, across 11 databases, utilizing search terms specifically tailored each database. All studies were reviewed qualitatively with specific focus on the outcomes of interest: the best-corrected visual acuity (BCVA), the central retina thickness (CRT), and the burden of therapy.

Results
We identified a total of 22 eligible studies of 1762 eyes from 1618 patients with nAMD. Studies reported that intravitreal faricimab injections maintained BCVA in patients with previously treated eyes and demonstrated statistically significant improvement in patients with treatment-naïve eyes. The CRT was reduced after intravitreal faricimab therapy. Faricimab was well-tolerated, with no significant safety concerns identified, and reduced the overall burden of therapy.

Conclusion
Real-world studies corroborate the conclusions drawn from phase-III trials regarding faricimab treatment, demonstrating improvement in both visual and anatomical outcomes. Additionally, no significant safety issues were identified, as the treatment was generally well-tolerated and reduced the overall burden of therapy in the real-world settings.
Clinical role of genetic testing for the Brugada syndrome overlapping with arrhythmogenic cardiomyopathy
Authors: Jeong Joo Hee , Lee Hyoung Seok , Choi Yun Young , Kim Yun Gi , Shim Jaemin , Hwang Jin Ha , Yun Seung Gyu , Cho Yun Jung , Kim Young-Hoon , Choi Jong-Il 
Published: July 2024

Abstract
Background
Brugada syndrome (BrS) and arrhythmogenic cardiomyopathy (ACM) are inherited cardiac diseases that may predispose to ventricular arrhythmia. Although overlapping features between BrS and ACM have been demonstrated previously, it remains to be determined whether genetic testing for ACM-related genes is needed in BrS probands.

Method
Based on a single-center, retrospective registry of BrS, we aimed to verify genetic profiles of BrS using a next-generation sequencing panel, and further analyzed genetic testing of ACM-related variants in Brugada phenotypes.

Results
Among a total of 119 Brugada phenotypes, 114 patients (95.8%) were male and the mean age of onset was 43.6 years. Genetic variants were identified in 25 of the 42 patients who underwent genetic testing. Fifteen patients had BrS-related genotypes, including SCN5A in 6 patients, and non-SCN5A genes in 9 patients (SCN10A, HCN4, SCN3B, and KCNE3). Nineteen patients underwent additional genetic testing with cardiomyopathy panel, which revealed ACM-related genotypes (2 PKP2, 1 DSG2, 1 TMEM43, 1 JUP, and 1 DSP) present in 6 patients (31.5%). None of the patients had structural or electrocardiographic features that fulfilled the diagnostic criteria for ACM.

Conclusions
In clinical setting, ACM-related genes were identified in a significant proportion of Brugada phenotypes, supporting the argument that genetic testing of ACM overlapping is needed. Follow-up imaging studies should be considered to monitor if the disease progresses to ACM.
Interatomic correlations moments in graphene monolayer
Authors: Gonçalves Rodrigues Clóves 
Published: July 2024

Abstract
This study investigated the interatomic correlation moments within a graphene monolayer using the correlative approach based on an unsymmetrized self-consistent field (CUSF) method. This analysis encompassed various approximations, such as the harmonic, quasi-harmonic, and weakly anharmonic models. Numerical evaluations for low temperatures were conducted employing the parametric interatomic potential specifically developed for graphene by Tewary and Yang. The findings revealed a notable reduction in the interatomic correlation moments with increased interatomic distance. Moreover, the correlations between the transverse atomic displacements were less pronounced than those between the longitudinal displacements. Additionally, the significance of anharmonicity was duly validated. Comparatively, the longitudinal atomic displacements in the graphene lattice exhibited a stronger correlation than the square and hexagonal lattices.
A Rare Case of Papillary Thyroid Carcinoma in Marine-Lehnhart Syndrome—Indication for Biopsy of Hot Thyroid Nodules?
Authors: Masjkur Jimmy , Thurnheer Martin , Maas Ole Christopher , Schuler Roland , Strey Christopher 
Published: July 2024

Abstract
An uncommon occurrence in which Graves disease (GD) coincides with autonomous functioning thyroid nodules (AFTNs) is termed Marine-Lehnhart syndrome (MLS). While hyperfunctioning nodules in MLS are commonly benign, there exists a rare potential for malignancy. A 41-year-old male patient was initially managed conservatively upon being diagnosed with MLS type 1. However, the emergence of obstructive symptoms prompted a thyroidectomy 4 years after initial presentation. Histological analysis revealed 2 cervical lymph node metastases and papillary thyroid cancer (PTC) within the AFTN.
Polish psychotherapists and their generational attitudes towards supervision.
Authors: Galiński Kamil , Gierus Jacek 
Published: July 2024

Cel pracyBadanie miało na celu zebranie danych demograficznych opisujących populację polskich psychoterapeutów pracujących w różnych modalnościach oraz zbadanie ich potrzeb w superwizji. Dodatkowo artykuł podejmuje problematykę różnic międzypokoleniowych pomiędzy psychoterapeutami na podstawie teorii pokoleniowych.MetodaBadanie przeprowadzono za pomocą autorskiej ankiety, dystrybuowanej online w 2022 r. (N = 257). Ankieta składała się z 34 pytań dotyczących potrzeb w superwizji, w tym 4 pytań całkowicie otwartych i jednego zadania specjalnego.Wyniki: Analizy z zebranych danych sugerują, że superwizja cieszy się wysokim zainteresowaniem wśród polskich profesjonalistów (98% badanych korzysta z superwizji, z czego 61% korzysta z niej w trybie online lub mieszanym). Wykryto istotne różnice pomiędzy starszymi a młodszymi psychoterapeutami (chi-kwadrat = 14,682; p = 0,023) pod względem spostrzeganych różnic między superwizją online i superwizją na żywo. Nie wykryto istotnych różnic pomiędzy poszczególnymi pokoleniami w spostrzeganiu superwizji w innych badanych wymiarach. Analiza rang wykazała, że najważniejszą potrzebą w superwizji jest: uważność superwizora ułatwiająca uporządkowanie procesu terapeutycznego.WnioskiUzyskano liczne wyniki opisujące populację polskich psychoterapeutów. Stwierdzono brak istotnych różnic pokoleniowych w formie korzystania z superwizji. Teorie pokoleniowe nie wykazują w tym obszarze użyteczności i na podstawie zebranych danych można je traktować jako stereotypowe. Hierarchia potrzeb superwizantów zdaje się nie odbiegać znacząco od poprzedniego polskiego badania opisującego tę tematykę. Autorzy uszeregowali potrzeby w superwizji według ich ważności i zaproponowali „odwróconą piramidę potrzeb” w superwizji.
Do Proprietary Costs Deter Insider Trading?
Authors: Choi Lyungmae , Faurel Lucile , Hillegeist Stephen 
Published: July 2024

Insider trading conveys insiders’ private information to outsiders. This private information potentially benefits rival firms, which may reduce the competitive advantage of the insiders’ firms. Using a composite proprietary cost measure, we find proprietary costs are negatively associated with insiders’ purchases, especially when their trades are more likely to be informative to rivals. Consistent with proprietary costs increasing the costs of insider purchases and, hence, the expected benefits required to trade, insiders earn significantly higher abnormal profits when proprietary costs are higher. Exploiting settings with exogenous and event-driven variation in proprietary costs, we find insiders significantly reduce their purchases when noncompete agreement enforceability is high and before new product launches. Moreover, firms with higher proprietary costs are more likely to impose window-based insider trading restrictions and insiders with greater equity holdings reduce their purchases more strongly in the presence of proprietary costs. Finally, we provide evidence of real effects of insider trading on rivals’ investment decisions. We find that investments are associated with insiders’ purchases at rival firms, and these associations are stronger when proprietary costs at rivals are higher. Our findings indicate insiders and firms are aware of potential proprietary costs when insiders trade on private information and respond accordingly. This paper was accepted by Suraj Srinivasan, accounting. Supplemental Material: The online appendices and data files are available at https://doi.org/10.1287/mnsc.2021.02469 .
Analysis of long-term outcome of modified gastric bypass for type 2 diabetes mellitus in Chinese patients
Authors: Xing Ying , Bai Ri-Xing , Li You-Guo , Xu Jun , Zhong Zhi-Qiang , Yan Ming , Yan Wen-Mao 
Published: July 2024

BACKGROUND
Bariatric and metabolic surgery have been routinely performed following the rapid increase in obesity and metabolic diseases worldwide. Of all evolving procedures, Roux-en-Y gastric bypass (RYGB) is considered the gold standard for surgical treatment of patients with type 2 diabetes mellitus (T2DM) and obesity. RYGB was introduced in China nearly 20 years ago, but the number of RYGB surgeries only accounts for 3.1% of the total number of weight loss and metabolic surgeries in China, it’s effect on Chinese people still needs further study.
AIM
To investigate the effect and safety of a modified gastric bypass performed in Chinese patients with T2DM.
METHODS
Patients with obesity and T2DM who underwent modified gastric bypass, with > 5-year follow-up data, were analyzed.
RESULTS
All 37 patients underwent uneventful laparoscopic surgery, no patient was switched to laparotomy during the surgery, and no severe complications were reported. Average weight and body mass index of the patients reduced from 84.6 ± 17.3 (60.0–140.0) kg and 30.9 ± 5.0 (24.7–46.2) kg/m2 to 67.1 ± 12.2 (24.7–46.2) kg and 24.6 ± 3.9 (17.7–36.5) kg/m2, respectively, and fasting plasma glucose and glycated hemoglobin decreased from 7.4 ± 3.4 mmol/L and 8.2% ± 1.7% preoperatively to 6.5 ± 1.3 mmol/L and 6.5% ± 0.9% 5-years postoperatively, respectively. Only 29.7% (11/37) of the patients used hypoglycemic drugs 5-years postoperatively, and the complete remission rate of T2DM was 29.7% (11/37). Triglyceride level reduced significantly but high-density lipoprotein increased significantly (both P < 0.05) compared with those during the preoperative period. Liver and renal function improved significantly postoperatively, and binary logistic regression analysis revealed that the patients’ preoperative history of T2DM and fasting C-peptide were significant prognostic factors influencing complete T2DM remission after RYGB (P = 0.006 and 0.012, respectively).
CONCLUSION
The modified gastric bypass is a safe and feasible procedure for Chinese patients with obesity and T2DM, exhibiting satisfactory amelioration of weight problems, hyperglycemia, and combination disease.