bluuebunny/crossref_metadata_2025_split huggingface dataset:
350-OR: Parturition Event Regulates Endocrine Genesis during Pancreas Differentiation
Authors: SUZUKI AGENA , TAGUCHI TOMOMI , ITO SHIORI , SHIMOTATARA HIDEAKI , KIMURA KAORI , SHIMIZU NAOYA , FUJISHIMA REI , HIMURO MIWA , MIYATSUKA TAKESHI 
Published: July 2024

It is essential to decipher developmental features of each endocrine cell, which leads to exploring efficient methods for generating surrogate β cells. We previously developed three reporter mouse lines to quantify the genesis of endocrine progenitor cells, β cells, and α cells. Flow cytometry analysis revealed a significant decrease in the number of newly-generated endocrine progenitors and β cells after birth. Based on these findings, we hypothesized that environmental changes during parturition could affect endocrine genesis. The number of newly-generated endocrine cells was quantified with the reporter mouse lines at the following stages: (i) embryonic day 19.5 (E19.5) embryos, whose parturitions were prolonged by progesterone or COX-1 inhibitor SC-560 vs. newborn pups at postnatal day 0.5 (P0.5) (both were dissected at 19.5 days after coitus), and (ii) premature pups treated with anti-progesterone drug RU-486 (both were at 18.5 days after coitus) vs. E18.5 embryos. Flow cytometry with Neurog3-Timer pancreata demonstrated that the percentage of green-fluorescent progenitors was (i) significantly higher in E19.5 embryos than in P0.5 pups (0.80% vs. 0.22%, p&lt;0.001), and (ii) significantly lower in premature pups than in E18.5 embryos (0.66% vs. 0.93%, p=0.0018). Likewise, flow cytometry with Ins1-Timer pancreata resulted in a significant increase in β-cell genesis at E19.5 than at P0.5 (0.36% vs. 0.16%, p&lt;0.001). Surprisingly, flow cytometry with Gcg-Timer mice resulted in (i) a significant decrease in α-cell genesis at E19.5 than at P0.5 (2.1% vs. 2.4%, p=0.035), and (ii) a significant increase in premature pups 18.5 days after coitus than in E18.5 embryos (0.77% vs. 0.58%, p=0.022), which is in contrast with the findings in Neurog3-Timer and Ins1-Timer pancreata. Thus, parturition events suppress the generation of endocrine progenitors and β cells, but not α-cell genesis, which may reflect distinct molecular mechanisms in α-cell lineage during parturition.

Disclosure
A. Suzuki: None. T. Taguchi: None. S. Ito: None. H. Shimotatara: None. K. Kimura: None. N. Shimizu: None. R. Fujishima: None. M. Himuro: None. T. Miyatsuka: None.
Evaluating the Competitiveness of the Methods of Bored Cast-in-Place Piles Underreaming when Constructing the Foundations of Multistorey Buildings
Authors: Osmanov S. G. , Inyakhin A. E. 
Published: July 2024

Introduction. The bored сast-in-place piles are the type of piles most adjusted to specifics of the multistorey building construction. The article studies the existing methods of underreaming such piles as the main tool to minimise their diameter, length, and quantity, thus optimise and reduce the cost of foundation design and its subsequent construction. It is acknowledged that despite the diversity of these methods, the information about them is scattered, confusing, and sometimes contradictory, making it difficult to choose the optimal design solutions. To facilitate the choice, an application-oriented classification of the methods under study has been proposed aiming to specify the areas of rational implementation thereof.Materials and Methods. The study took into account the data of the guidebooks on norms of production and estimate norms, the reference, normative and standard design documentation, as well as national practices and solutions proposed by the professional subcontracting organisations. Upon analysis of the above materials, the information on the advantages, disadvantages and implementation area parameters of the existing methods of bored cast-in-place piles underreaming was systematised based on the internal and external factor criteria used for selecting the appropriate solutions in the competitive conditions of multistorey building construction. The competitiveness of three most advanced of such methods was investigated by a comprehensive (multi-criteria) evaluation method. Results. It was found that under general conditions that were studied, the most competitive among the selected methods was mainly the pulse-discharging treatment of a pile shaft and (or) pile base. The respective results were presented graphically in the form of the bar charts of unit labour costs and costs of underreaming by the studied method, as well as the radial bar charts showing the cumulative effect of these and other taken into account parameters on solving the set task of optimisation. Discussion and Conclusion. The reflections upon the efficiency of implementing the obtained results in the present-day designing have been further evolved, and the ways and circumstances of changing thereof depending on the project specification and local conditions of construction have been presented. On the whole, that allowed for specifying the areas of rational implementation of the studied methods and providing the recommendations on updating the relevant regulatory framework.
ANALISIS PERBANDINGAN HASIL BELAJAR SISWA SECARA DARING DAN LURING MATA PELAJARAN MATEMATIKA
Authors: Selvie Selvie , Komariah Siti , Septianawati Desty 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui perbedaan hasil belajar matematika secara daring dan luring pada siswa jurusan MIA angkatan 19 di SMA Negeri 1 Tebas. Penelitian ini merupakan penelitian pendekatan kualitatif dengan jenis penelitian fenomenologi untuk mencari tahu rata-rata hasil belajar matematika siswa ketika pembelajaran daring dan pembelajaran luring. Adapun tahapan penelitian ini terdiri dari tahap orientasi yang dilakukan melalui wawancara awal dengan salah satu guru Matematika di SMA Negeri 1 Tebas. Tahap kedua yaitu tahap ekplorasi dengan teknik pengumpulan data adalah menggunakan teknik non tes melalui wawancara dan dokumentasi. Kemudian tahap yang ketiga yaitu analisis data dengan cara triangulasi. Hasil penelitian menunjukkan bahwa hasil belajar matematika siswa secara luring lebih unggul dibanding hasil belajar siswa secara daring. Dimana rata-rata hasil belajar siswa kelas XI MIA dalam pembelajaran daring adalah 74,13 sedangkan rata-rata hasil belajar siswa kelas XII MIA dalam pembelajaran luring adalah 79,66. Hal ini menunjukkan bahwa terdapat perbedaan dari hasil belajar matematika secara daring dan luring pada siswa jurusan MIA angkatan 19 di SMA Negeri 1 Tebas.
SYSTEMATIC LITERATURE REVIEW: KEMAMPUAN PEMBUKTIAN MATEMATIKA MAHASISWA
Authors: Wardani Putri , Hasanah Rusi Ulfa , Rifai Muhammad 
Published: July 2024

Adanya tujuan dari penelitian ini adalah untuk mengetahui seberapa besar kemampuan pembuktian matematika mahasiswa. Belakangan ini dapat kita lihat mahasiswa jurusan matematika banyak yang mengalami kesulitan dalam membuktikan matematika, baik diselesaikan secara langsung maupun tidak langsung. Penelitian ini menggunakan Systematic Literature Review yang diambil dari beberapa jurnal terbitan 2018-2023. Hasil penelitian menunjukkan bahwa pembuktian matematika mahasiswa belum tercapai secara keseluruhan. Dikarenakan dari beberapa mahasiswa tidak mengetahui dasar-dasar konsep matematika, sehingga langkah-langkah pembuktiannya tidak dapat diselesaikan dengan benar. Namun beberapa dari mahasiswa yang memiliki kemampuan tinggi sudah dapat menyelesaikan dengan benar, hanya saja pengerjaannya tidak dilakukan secara sistematis.
DESAIN PEMBELAJARAN MATEMATIKA BERBANTUAN MATH MAZE UNTUK MEMFASILITASI RETENSI DAN MINAT BELAJAR PESERTA DIDIK
Authors: Saputra Samnur , Kosasih Usep , Kusumaningtyas Sarah 
Published: July 2024

Kurangnya minat belajar peserta didik terhadap pembelajaran matematika berdampak pada daya ingat terhadap suatu materi yang diajarkan. Hal ini merupakan tantangan bagi pendidik untuk mencari metode pembelajaran yang tepat. Sehingga, perlu untuk mengembangkan metode pembelajaran dengan berbantuan games untuk materi barisan dan deret aritmetika. Tujuan penelitian adalah mengetahui kelayakan, daya retensi, dan minat belajar setelah pembelajaran matematika berbantuan Math Maze pada materi barisan dan deret aritmetika. Metode penelitian yang digunakan adalah Design Research (DR) dengan desain ADDIE. Data diperoleh melalui validator ahli media dan ahli materi serta peserta didik. Teknik pengumpulan data diantaranya lembar validasi, post-test dan re-test, penyebaran angket, dan wawancara. Dari hasil validasi Math Maze dikategorikan valid, daya retensi dikategorikan tinggi, dan minat belajar dikategorikan sangat tinggi.
AKTA PERDAMAIAN PUTUSAN NOMOR 1/Pdt.G.S/2019/PA.Ptk DI PENGADILAN AGAMA PONTIANAK TINJAUAN KOMPILASI HUKUM EKONOMI SYARIAH
Authors: Siregar Rekha Agustriani , Suhardiman Suhardiman 
Published: July 2024

Penelitian ini bertujuan untuk menjelaskan konstruksi akta perdamaian pada perkara ekonomi syariah dalam putusan Nomor 1/Pdt.G.S/2019/PA.Ptk yang terdaftar di Pengadilan Agama Pontianak pada tanggal 27 Agustus 2019. Pertanyaan penelitian ini adalah: 1). Apa isi akta perdamaian dalam Putusan Pengadilan Agama dalam perkara Nomor 1/Pdt.G.S/2019/PA.Ptk. 2). Bagaimana kontruksi hukum pada putusan perkara Nomor 1/Pdt.G.S/2019/PA.Ptk. 3). Serta bagaimana implikasinya terhadap konsep perdamaian dalam Kompilasi Hukum Ekonomi Syariah (KHES). Metode penelitian ini bersifat kualitatif dengan pendekatan yuridis- normatif. Sumber utama data diperoleh dari akta perdamaian Nomor 1/Pdt.G.S/2019PA.Ptk yang kemudian dianalisa menggunakan metode konten analisis. Selanjutnya, temuan tersebut diperkuat dan dikonfirmasi melalui wawancara dengan hakim di Pengadilan Agama Pontianak. Adapun data sekunder adalah Kompilasi Hukum Ekonomi Syariah (KHES) dan berbagai pendapat ahli hukum Islam tentang perdamaian. Kesimpulan penelitian ini adalah: 1). Hakim tidak merujuk secara langsung terhadap dalil-dalil syariat untuk memutuskan perkara akta perdamaian ini. 2). Akibatnya, putusan hakim pada akta perdamaian ini tidak menunjukkan perbedaan yang penting dengan putusan hakim di Pengadilan Negeri. 3). Hakim tidak menggunakan Kompilasi Hukum Ekonomi Syariah (KHES) sebagai salah satu dasar pertimbangannya dalam menjelaskan makna dan mekanisme perdamaian dalam Islam. Argumentasi penelitian ini adalah bahwa akta perdamaian ini tidak sepenuhnya merujuk pada sumber-sumber syariat, namun cenderung menyetujui apa yang sudah ditetapkan oleh pihak-pihak yang berperkara. Meskipun demikian, akta perdamaian ini sesuai dengan norma-norma hukum Islam tentang perjanjian, yaitu semua orang Islam terikat dengan perjanjian yang mereka buat.
KHIYAR DALAM JUAL BELI DENGAN SISTEM RETUR ANTARA DISTRIBUTOR DAN RESELLER
Authors: Oktaviandra Rio , Fahmi Moch. Riza , Suhardiman Suhardiman 
Published: July 2024

Penelitian ini bertujuan untuk menegetahui praktik tinjauan Kompilasi Hukum Ekonomi Syariah terhadap khiyar dalam jual beli dengan sistem retur antara distributor dan reseller Roti Royal di Kecamatan Sungai Kakap Kabupaten Kubu Raya. Penelitian ini menggunakan metode kualitatif dengan jenis penelitian hukum emipiris. Sumber data menggunakan data primer dan data sekunder berupa buku, jurnal, skripsi dan artikel-artikel. Teknik pengumpulan data adalah wawancara dan dokumentasi. Teknik analisis data yang digunakan peneliti adalah melakukan pengumpulan data, reduksi data, penyajian data dan menarik kesimpulan. Hasil penelitian menunjukkan bahwa: 1) Perjanjian dan kesepakatan kedua belah pihak antara distributor dan reseller adalah perjanjian secara lisan karena kedua belah pihak mempercayai satu sama lain dan tidak merugikan pihak manapun. 2) Tinjauan Kompilasi Hukum Ekonomi Syariah terhadap khiyar di Kecamatan Sungai Kakap Kabupaten Kubu Raya dibolehkan karena telah menerapkan khiyar ‘aib dan khiyar syarat. Kemudian, dalam jual beli ini bahwa barang yang ‘aib telah dijelaskan sebelumnya oleh distributor dan reseller pun telah mengetahui kondisi fisik dari barang tersebut.
Retrospective analysis of carboplatin-induced cumulative neutropenia in cancer-bearing dogs
Authors: Fan Vivian , Delport-Reynolds Tamara , MacDonald-Dickinson Valerie , Matsuyama Arata 
Published: July 2024

Abstract

OBJECTIVE
To determine the clinical significance of performing repeated postchemotherapy CBC for cancer-bearing dogs receiving ≥ 4 carboplatin treatments. The secondary aim was to identify risk factors associated with cumulative carboplatin-induced neutropenia in those dogs.

ANIMALS
40 client-owned dogs diagnosed with cancer.

METHODS
A retrospective study using medical records from a single academic institution during 2012 to 2023. Dogs that received ≥ 4 doses of carboplatin with pre- and postchemotherapy CBCs available were included. Signalment and possible risk factors were recorded. Veterinary Cooperative Oncology Group–Common Terminology Criteria for Adverse Events was used for neutropenia grading.

RESULTS
40 dogs met the inclusion criteria, with a total of 206 prechemotherapy and 188 postchemotherapy CBC results available. The median carboplatin dosage was 300 mg/m2 (range, 200 to 300 mg/m2). The median interval between carboplatin administration and the postchemotherapy CBC was 10 days (range, 6 to 38 days). Eleven dogs developed a grade 2 or higher neutropenia, with 5 dogs developing multiple neutropenic events, for a total of 18 separate events (18/394). Only 2 of 18 neutropenic events were recorded at the 10- to 14-day postchemotherapy CBC. The yield of detecting neutropenia at a postchemotherapy CBC at any carboplatin chemotherapy after the second dose was < 1% (1/149). Dogs that developed neutropenia at the pre-2nd chemotherapy CBC had a significantly higher risk of developing another neutropenic event at subsequent prechemotherapy CBC (P < .001).

CLINICAL RELEVANCE
The incidence of cumulative neutropenia after 4 to 6 doses of carboplatin is low in cancer-bearing dogs. If a grade 2 or higher neutropenia is observed at or before the second prechemotherapy CBC, the dog is at a higher risk of developing neutropenia following future treatments.
The Influence of Clomazone-Based Herbicide Formulation on Common Carp (Cyprinus carpio) – A Laboratory Study Including Pathophysiological and Histopathological Assessment
Authors: Bojarski Bartosz , Osikowski Artur , Rombel-Bryzek Agnieszka , Hofman Sebastian , Szała Leszek 
Published: July 2024

Abstract
Herbicides are widely applied in agriculture, which results in the pollution of ecosystems, including inland waters. Herbicides present in water may cause pathological changes in fish. The aim of this study was to evaluate the effects of a clomazone-based herbicide formulation, Command 480 EC, on the haematological and blood biochemical parameters of common carp as well as the microstructure of selected organs: gills, liver and trunk kidney. The fish were exposed to Command 480 EC at a concentration corresponding to 1 or 5 mg/l of clomazone (groups COM1 and COM2, respectively) for 10 days. The conducted analyses showed that the treatment caused numerous changes in red blood cell parameters, no significant changes in WBC count (in comparison to the control), and only a few transient changes in the leukogram. The only significant change in the biochemical parameters in comparison to the control was a decrease in the triglyceride concentration in fish observed after 3 days (group COM1) and 10 days (group COM2) of exposure to this herbicide. No considerable histopathological alterations were observed. The results of the present study suggest that exposure to the applied clomazone-based formulation can cause pathophysiological changes in common carp. It was also observed that blood parameters (especially haematological ones) are more sensitive markers of exposure to Command than the microstructure of the tested organs.
Possibilities of Using Hemp (Cannabis sativa L.) and its By-Products in Sheep Nutrition – A Review
Authors: Taşkesen Hulüsi Ozan , Tüfekci Hacer 
Published: July 2024

Abstract
Industrial hemp (Cannabis sativa L.) is a highly commercialized crop used in the production processes of more than 25,000 products in many different industries. Industrial hemp is a versatile, sustainable plant with a variety of applications in its various forms, including fibre from hemp stalks, foods from hemp seeds, and oil from hemp flowers and seeds. Hemp seeds in their hulled or whole form, stalks and grass, leaves, oil and oil meal have high potential for use as an alternative raw feed material in animal nutrition. Considering the fact that the share of feed cost in overall production costs in animal husbandry is around 70%, and the most important part of this feed cost is the protein source feed raw materials, it is important to reveal the possibilities of using alternative feed raw materials. Although there are many studies in the field of animal nutrition using hemp and its by-products, studies in sheep are limited. Because of their tendency to extensive feeding and their ability to use feed resources that other animals cannot use, sheep are known to breed well with a wide range of alternative feedstuffs. Due to these characteristics, research on feeding hemp to sheep has been increasing in recent years. In this review, the nutrient contents of hemp and its products and the findings of previous studies on feeding hemp to sheep were summarized and the possibilities of using hemp in sheep feeding were strived to be revealed.
Free economic zone: how to create better conditions for a business incubator
Authors: Осипов С.Ю. 
Published: July 2024

Актуальность исследуемой проблемы обусловлена важностью успешного развития свободных экономических зон для любой страны. Статья направлена на проведение исследования в сфере деятельности свободных экономических зон. Ведущими подходами к данному исследованию является уточнение действующих определений, введение нового термина и классификации. Результатами статьи являются проведение анализа проблем и преимуществ зон свободной торговли мира и разработка на его основе оптимальной модели свободной экономической зоны с учетом особенностей страны. Материалы статьи могут быть полезными для изучения региональной экономики студентами учебных заведений, а также при создании и развитии зон свободной торговли
The urgency of the problem under investigation is determined by the importance of the successful development of free economic zones for any country. The article is aimed at conducting research in the field of activity of free economic zones. The leading approaches to this study are the refinement of the current definitions, the introduction of a new term and classification. The results of the article are an analysis of the problems and advantages of the free trade areas of the world and the development on its basis of an optimal model of a free economic zone, taking into account the characteristics of the country. The materials of the article can be useful for studying the regional economy by students of educational institutions, as well as in the creation and development of free trade zones
Indirect method for assessing the consumption of socially harmful goods
Authors: Малыгина В.Д. , Гросова Д.А. 
Published: July 2024

В статье представлены результаты социологического исследования, проведенного с целью выявления интереса и мотивации к приобретению социально вредных товаров, а именно никотиносодержащих товаров, алкогольных напитков, и фаст-фуда. Полученные данные позволили определить косвенным методом причины, частоту и количество потребления социально вредных товаров.
The article presents the results of a sociological study conducted to identify interest and motivation in the acquisition of socially harmful goods, namely alcoholic beverages, nicotinecontaining products and fast food. The data obtained made it possible to determine by an indirect method the causes, frequency and amount of consumption of socially harmful goods.
Diversification as a developer's tool in the construction sector
Authors: Абрамов Н.Н. 
Published: July 2024

Актуальность статьи заключается тем, что затронутая тема неразрывно связана со строительной сферой последние годы, и играет важнейшую роль в жилом строительстве в Российской Федерации. Цель исследования определяется в названии статьи, то есть мы рассмотрим, как компании используют диверсификацию в своей строительной деятельности в Российской Федерации. Практическая значимость: в статье рассмотрены несколько реальных примеров диверсификации, используемые застройщиками. Статья будет интересна ученым-экономистам, студентам экономических и строительных вузов для расширения и углубления знаний в предметной области.
The relevance of the article lies in the fact that the affected topic is inextricably linked with the construction sector in recent years, and plays an important role in residential construction in the Russian Federation. The purpose of the study is defined in the title of the article; therefore, we will consider how companies use diversification in their construction activities in the Russian Federation. Practical significance: the article discusses several real-world examples of diversification used by developers. The article will be of interest to economic scientists, students of economic and construction universities to expand and deepen knowledge in the subject area.
Formation of Russian Identity in the Crimea and Sevastopol City
Authors: Evgenieva T. V. 
Published: July 2024

The Republic of Crimea and the city of Sevastopol have not yet completed the process of reintegration today. In this context, it is necessary to pay attention to its political and psychological component — the problem of creating the Russian national-state identity. The political-psychological approach involves analyzing not only the rational aspects of this process but also the place of unconscious factors in it, including the symbolic space of identity. The study involved researchers from Sevastopol University who conducted a questionnaire survey comprising closed and open questions. The sample selected for the study represented two regions. Their survey included 2,100 respondents. The researchers identified elements such as the image of the territory, the idea of personalities with symbolic meaning, and historical symbols for the study.
Concept of Martingale in random Processes: from Game system to financial Mathematics
Authors: Gisin V. B. , Panov E. G. 
Published: July 2024

The proposed study undertakes an interdisciplinary analysis of the problem of randomness in various forms of social activity. The authors find a significant relation between linguistic analysis and the conclusions of financial mathematics about the possibility of forecasting under conditions of uncertainty. It realizes the intention to find a strategy for profitable actions in random processes. This intention is reflected in the meaning of the concept “martingale”. For centuries it was used to refer to the special capabilities of horse harnesses. Then this term began to denote winning strategies in various gambling games, leading to the enrichment of the one who owns them. The introduction of mathematical calculations into these strategies became one of the foundations of probability theory. In the middle of the last century, the term “martingale” began to denote the process of capital accumulation when implementing a trading strategy in the financial market. In recent years, the concept of martingale began to characterize calculated strategies for playing in the financial market. This opened up the possibility of forming a version of probability theory specially adapted for modeling market phenomena and processes. The emergence of the science of quantum computing and the emergence of new computing capabilities revives the problem of overcoming uncertainty using the means of modern digitalization. Therefore, the concept of martingale, which implies the search for opportunities to control random processes, remains relevant not only for modern economic thought, but also for various areas of social and humanitarian knowledge. Analysis of the nature of randomness and its various manifestations is also relevant for everyday life of modern people.This makes it relevant for educational programs aimed at promoting economic and financial literacy among the population.