bluuebunny/crossref_metadata_2025_split huggingface dataset:
Trigger Point Dry Needling as an Adjunct Treatment for a Patient With Adhesive Capsulitis of the Shoulder
Authors: Clewley Derek , Flynn Timothy W. , Koppenhaver Shane 
Published: November 2013

Study Design Case report. Background Prognosis for adhesive capsulitis has been described as self-limiting and can persist for 1 to 3 years. Conservative treatment that includes physical therapy is commonly advised. Case Description The patient was a 54-year-old woman with primary symptoms of shoulder pain and loss of motion consistent with adhesive capsulitis. Manual physical therapy intervention initially consisted of joint mobilizations of the shoulder region and thrust manipulation of the cervicothoracic region. Although manual techniques seemed to result in some early functional improvement, continued progression was limited by pain. Subsequent examination identified trigger points in the upper trapezius, levator scapula, deltoid, and infraspinatus muscles, which were treated with dry needling to decrease pain and allow for higher grades of manual intervention. Outcomes The patient was treated for a total of 13 visits over a 6-week period. After trigger point dry needling was introduced on the third visit, improvements in pain-free shoulder range of motion and functional outcome measures, assessed with the Shoulder Pain and Disability Index and the shortened form of the Disabilities of the Arm, Shoulder and Hand questionnaire, exceeded the minimal clinically important difference after 2 treatment sessions. At discharge, the patient had achieved significant improvements in shoulder range of motion in all planes, and outcome measures were significantly improved. Discussion This case report describes the clinical reasoning behind the use of trigger point dry needling in the treatment of a patient with adhesive capsulitis. The rapid improvement seen in this patient following the initiation of dry needling to the upper trapezius, levator scapula, deltoid, and infraspinatus muscles suggests that surrounding muscles may be a significant source of pain in this condition. Level of Evidence Therapy, level 4. J Orthop Sports Phys Ther 2014;44(2):92–101. Epub 21 November 2013. doi:10.2519/jospt.2014.4915
The Within-Session Change in Low Back Pain Intensity Following Spinal Manipulative Therapy Is Related to Differences in Diffusion of Water in the Intervertebral Discs of the Upper Lumbar Spine and L5-S1
Authors: Beattie Paul F. , Butts Raymond , Donley Jonathan W. , Liuzzo Derek M. 
Published: November 2013

Study Design Single-group, prospective, repeated-measures design with responder analysis. Objective To determine differences in the changes in diffusion of water within the lumbar intervertebral discs between participants with low back pain who reported a within-session reduction in pain intensity following a single treatment of spinal manipulative therapy and those who did not. Background There is a paucity of research that describes the physiologic events associated with analgesia following intervention for low back pain. Postintervention increases in the diffusion of water within various soft tissues of the spine may be one of many potential mechanisms linked to pain reduction. Methods Nineteen adults between 20 and 45 years of age participated in this study. All participants reported low back pain of at least 2 on an 11-point (0–10) verbally administered numeric pain rating scale at the time of enrollment. Participants underwent T2- and diffusion-weighted lumbar magnetic resonance imaging scans immediately before and after receiving a single treatment of spinal manipulative therapy. Individuals who reported a decrease in current pain intensity of more than 2 following treatment were classified as “within-session responders,” and the remainder were classified as “not-within-session responders.” The apparent diffusion coefficient (ADC), representing the diffusion of water in the nucleus pulposus, was calculated from ADC maps derived from the midsagittal diffusion-weighted images. Results Two-way, repeated-measures analyses of variance indicated significant group-by-time interactions. Participants in the within-session-responder group (n = 12) had a postintervention increase in ADC at L1-2 (P = .001), L2-3 (P = .002), and L5-S1 (P = .01) compared to those in the not-within-session-responder group (n = 7). Large effect sizes in ADC between responder groups were observed at L1-2 (d = 1.74), L2-3 (d = 1.83), and L5-S1 (d = 1.49). No significant group-by-time interactions were observed at the L3-4 and L4-5 levels. Conclusion Changes in the diffusion of water within the lumbar intervertebral discs at the L1-2, L2-3, and L5-S1 levels appear to be related to differences in within-session pain reports following a single treatment of spinal manipulative therapy. J Orthop Sports Phys Ther 2014;44(1):19–29. Epub 21 November 2013. doi:10.2519/jospt.2014.4967
Experimental Hbsag/Anti-Hbs Complex Assay for Prediction of Hbeag Loss in Chronic Hepatitis B Patients Treated with Pegylated Interferon and Adefovir
Authors: de Niet Annikki , Jansen Louis , Zaaijer Hans L , Klause Ursula , Takkenberg Bart , Janssen Harry LA , Chu Tom , Petric Rosemary , Reesink Hendrik W 
Published: November 2013

Background We studied whether hepatitis B surface antigen (HBsAg)/anti-HBs immune complex levels in chronic hepatitis B (CHB) patients receiving antiviral therapy could be used as a response marker at baseline (BL) or early during treatment to predict treatment outcome. Methods An experimental array-based assay (immunological multi-parameter chip technology [IMPACT]; Roche Diagnostics, Penzberg, Germany) served to determine HBsAg, anti-HBs and complex levels. We tested a panel of serum samples of 40 hepatitis B e antigen (HBeAg)-positive and 44 HBeAg-negative patients who received pegylated interferon and adefovir for 48 weeks. Results HBsAg loss occurred in 4 of 40 HBeAg-positive and 4 of 44 HBeAg-negative patients. A total of 14 of 40 HBeAg-positive patients lost HBeAg and 12 of them formed anti-HBe. At BL, complexes were present in 83 (99%) patients, whereas free anti-HBs levels were detectable in 5 patients. Complex levels at BL and week 12 were higher in HBeAg-positive patients with HBeAg loss, compared to patients who retained HBeAg ( P=0.002 and P=0.005, respectively). Receiver operating characteristic analysis for HBeAg loss in HBeAg-positive patients at BL and week 12 showed area-under-the-curve values of 0.79 ( P=0.002) and 0.82 ( P=0.003) for complex levels. We found no correlation in either HBeAg-positive or -negative patients between complex levels and HBsAg loss. Conclusions We demonstrated for the first time that before and during treatment HBsAg/anti-HBs immune complex levels can predict HBeAg loss in HBeAg-positive CHB patients treated with pegylated interferon and adefovir. Complexes were present in almost all patients at BL and were higher in patients who lost HBeAg. In conclusion, determining HBsAg/anti-HBs immune complex levels before and early during treatment could aid in selecting CHB patients with an optimal chance to achieve HBeAg loss.
Les internats d'excellence : la construction d'un dispositif
Authors: Boulin Audrey 
Published: November 2013

À partir de la fin des années quatre-vingt-dix, une politique de relance de l’internat est amorcée. Dans le but de promouvoir l’égalité des chances, le plan « Espoir banlieues » (2008) propose l’accès en internat pour les élèves issus de milieux défavorisés. Étant donné l’importante marge de manœuvre laissée aux professionnels, ce dispositif national s’est vu se décliner selon les situations locales. C’est à partir d’une monographie d’un internat d’excellence – possible grâce à une enquête qualitative de deux ans (entretiens et observations), combinée aux résultats d’un travail d’équipe réalisé sur sept structures – que l’on mettra en avant l’évolution du dispositif. Du fait des difficultés de mise en place d’un projet innovant la première année, le dispositif se centre, la seconde année, sur les activités traditionnelles de la forme scolaire. Mais, plus que la recherche d’innovation pédagogique, c’est l’idée d’adaptation perpétuelle qui est centrale dans la construction du dispositif.
L'ère de l'évaluation aux Etats-Unis et l'intégration du baccalauréat international comme dispositif pour améliorer les lycées publics
Authors: Resnik Julia 
Published: November 2013

Depuis le milieu des années 1980, mais tout spécialement à partir des années 2000, on observe la montée en puissance de l’évaluation de l’éducation aux États-Unis ainsi que l’expansion du choix des parents et la multiplication de magnet schools . C’est ce scénario qui permet l’intégration du baccalauréat international (BI) dans des établissements publics peu performants. Sur la base des études de cas de trois lycées dans l’État de New York, en Floride et en Californie, cet article analyse les différentes stratégies d’intégration du BI à ces établissements, stratégies qui tiennent compte, d’une part, des politiques fédérales, de l’État et de celles du district et, d’autre part, des spécificités de leur population. Ces cas illustrent les limites des politiques visant à l’amélioration globale du niveau des élèves : les établissements progressent grâce aux résultats d’une petite minorité de très bons élèves mais les populations en difficulté ne profitent guère des dispositifs tels que le BI.
La montée des dispositifs : un nouvel âge de l'organisation scolaire
Authors: Barrère Anne 
Published: November 2013

Le mot de « dispositif » est aujourd’hui très fréquemment employé dans le monde scolaire. On le trouve dans des textes officiels ou institutionnels, mais aussi dans nombre de travaux de recherches sur les établissements scolaires. Pourtant, dans la plupart des cas, il est utilisé sans grande précision ni problématisation. Cet article vise à le prendre au sérieux, à tenter d’en définir les usages en faisant le pari que son extension sémantique permet de mieux cerner les réalités scolaires contemporaines. Dans un premier temps, nous montrerons comment, tout en restant fidèle à une certaine analyse de l’école comme ensemble d’instruments et d’équipements, il en est venu à désigner certains d’entre eux, infléchissant la forme scolaire traditionnelle. Puis, nous mettrons alors en évidence leurs fonctions stratégiques qui révèlent et prennent en charge à bien des égards les hésitations actuelles de l’institution solaire, tant sur le plan de ses finalités que de ses modalités d’action.
Management of Enamel White Spot Lesions
Authors: Joshi Surabhi , Joshi Chintan 
Published: November 2013

ABSTRACTDental caries is a highly prevalent multifactorial disease and is a major public health problem. A goal of modern dentistry is to manage enamel white spot lesions noninvasively and effectively an attempt to prevent disease progression and improve esthetics, strength and function. The progression of caries has been tried to be curbed at initial stage only but for that only use of fluoride application was suggested but with recent developments in dental materials other remineralization options as well as noninvasive masking procedure can be performed to attain best result. This article reviews all the materials and techniques mentioned in the literature to manage the world's most common disease in its initial stage only.How to cite this articleJoshi S, Joshi C. Management of Enamel White Spot Lesions. J Contemp Dent 2013;3(3):133-137.
Comparison of Guided Bone Regeneration using a Bovine Collagen Membrane vs a Calcium Sulfate Barrier
Authors: Rossmann Jeffrey A , Al-Hashimi Ibtisam , Solomon Eric S , Ghaly Mira , Kerns David G , Hallmon William W , Nagy William W 
Published: November 2013

ABSTRACTResorbable membranes have eliminated the need for re-entry for removal and reduce the incidence of adverse soft tissue reactions that accompany membrane exposure. However, the lack of rigidity often makes these more prone to collapse. Calcium sulfate has shown promise as a regenerative material alternative in a socket preservation application. The purpose of this study was to compare calcium sulfate and bovine collagen as a barrier in guided bone regeneration.Materials and MethodsEighteen sites were treated in this randomized, blinded clinical study. Patients were divided into 2 groups, 9 sites each. Group 1, had bovine collagen membrane (OssixTM) and group 2 had calcium sulfate barrier (CalcigenOralTM) to cover the graft. All sites were augmented with autogenously bone and demineralized freeze-dried bone composite graft at 1:1 ratio. Implants were placed in the grafted area 4 to 6 months post grafting. Vertical and horizontal ridge measurements were made before and after grafting by two blinded examiners.ResultsThe collagen membrane group had a mean bone gain of 1.06 ± 1.01 mm in width and 0.19 ± 1.11 mm in height. In comparison, the calcium sulfate group had a mean bone loss of –0.14 ± 0.74 mm in width and –0.19 ± 0.74 mm in height. Student t-test revealed a significant difference in width dimension between the two groups, p = 0.01.ConclusionOverall results of this study suggest that calcium sulfate might have limited use as barrier for ridge augmentation.How to cite this articleGhaly M, Kerns DG, Hallmon WW, Solomon ES, Nagy WW, Al-Hashimi I, Rossmann JA. Comparison of Guided Bone Regeneration using a Bovine Collagen Membranevsa Calcium Sulfate Barrier. J Contemp Dent 2013;3(3):138-143.
Microscopic examination of normal nail clippings
Authors: Werner Betina , Antunes Andre 
Published: November 2013

Background: Nail clipping analysis for diagnosing causes of onychodystrophy other than onychomycosis is investigated to a very small extent. In order to achieve acceptance as a diagnostic method for any kind of nail abnormalities, normal microscopic parameters have to be established first. In most reported cases, nail plates were fixed in formalin with processing of the specimens with routine automated histotechnique.
The Effect of Pretreatment with Chemotherapeutic Drugs on the Susceptibility to Lymphokine Activated CD8+ T Lymphocyte-Mediated Cytotoxicity in CMK Leukemia Cells
Authors: Bülent  Özgönenel  , Öner  Özdemir  , Melike  Özgönenel,  , Ronald  Thomas  , Steven  Buck  , Süreyya Savasan  
Published: November 2013

Objectives: Certain tumor cells pretreated with chemotherapeutic drugs become more susceptible to death by apoptosis induced by killer cells of the immune system. We examined the CD8+ cytotoxic T lymphocyte (CTL)-mediated cytotoxicity in myeloid leukemia cell lines pretreated with chemotherapeutic drugs.
Methods: Peripheral blood mononuclear cells were expanded in vitro in the presence of phytohemagglutinin-P, interleukins-2 and -15. CD3+ CD8+ cells representing the CTLs were isolated using magnetic immunoselection and used in immune cytotoxicity experiments against K562 and CMK leukemia cells, pretreated with two different concentrations of cytarabine and etoposide.
Results: In CMK cells pretreated with etoposide at 2 M and 20 M concentrations, the mean cell-mediated immune cytotoxicity rose to 21.4 ± 12.9% (p=0.09) and 23.4 ± 12.6% (p=0.046), respectively, when compared to the control value of 6.6 ± 3.8%. In CMK cells pretreated with cytarabine at 1 M and 10M concentrations, the mean immune cytotoxicity rose to 14.3 ± 11.2% and 22.6 ± 15.2%, respectively, compared to the control value of 8.7 ± 6.3%, although these results did not reach statistical significance. However, a similar increase in CTL-mediated immune cytotoxicity was not observed against drug-treated K562 cells.
Conclusion: This study suggests that pretreatment with chemotherapeutic drugs can render CMK leukemia cells more susceptible to immune attack by activated CTLs. Further studies are needed to explore this phenomenon, to establish an immune-enhancing effect of pretreatment with chemotherapy in the treatment of leukemia.
Multi‐Parametric Analysis of Cell Death Pathways Using Live‐Cell Microscopy
Authors: Joshi Gaurav N. , Knecht David A. 
Published: November 2013

AbstractProgrammed cell death is a complex process with new forms being discovered with regularity. Each pathway has a distinct and overlapping biochemical and physiological change occurring as the cell prepares for death. Detection of these changes can be facilitated by the availability of various fluorescent probes and advances in microscope systems. By analyzing these probes over time using fluorescence microscopy, the changes that occur in each cell en route to death can be analyzed on a cell‐by‐cell basis. While the timing of events varies considerably from cell to cell, it has been found that the sequence of events is highly conserved. Transient events, which would be difficult to detect using population averaging techniques, are readily detected when cells are analyzed individually in time lapse. The protocols in this unit describe using probes for real‐time imaging of one of the apoptotic cell death pathways using various inducers, as well as the associated hardware necessary for imaging so that the imaging itself is not affecting cell viability. Curr. Protoc. Toxicol. 58:4.40.1‐4.40.31. © 2013 by John Wiley & Sons, Inc.
Understanding controls on rapid ice‐stream retreat during the last deglaciation of Marguerite Bay, Antarctica, using a numerical model
Authors: Jamieson Stewart S. R. , Vieli Andreas , Cofaigh Colm Ó , Stokes Chris R. , Livingstone Stephen J. , Hillenbrand Claus‐Dieter 
Published: November 2013

AbstractUsing a one‐dimensional numerical model of ice‐stream flow with robust grounding‐line dynamics, we explore controls on paleo‐ice‐stream retreat in Marguerite Bay, Antarctica, during the last deglaciation. Landforms on the continental shelf constrain the numerical model and suggest that retreat was rapid but punctuated by a series of slowdowns. We investigate the sensitivity of ice‐stream retreat to changes in subglacial and lateral topography and to forcing processes including sea‐level rise, enhanced melting beneath an ice shelf, atmospheric warming, and ice‐shelf debuttressing. Our experiments consistently reproduce punctuated retreat on a bed that deepens inland, with retreat‐rate slowdowns controlled by narrowings in the topography. Sensitivity experiments indicate that the magnitudes of change required for individual forcing mechanisms to initiate retreat are unrealistically high but that thresholds are reduced when processes act in combination. The ice stream is, however, most sensitive to ocean warming and associated ice‐shelf melting, and retreat was most likely in response to external forcing that endured throughout the period of retreat rather than to a single triggering “event.” Timescales of retreat are further controlled by the delivery of ice from upstream of the grounding line. Due to the influence of topography, modeled retreat patterns are insensitive to the temporal pattern of forcing evolution. We therefore suggest that despite regionally similar forcing mechanisms, landscape controls significant contrasts in retreat behavior between adjacent but topographically distinct catchments. Patterns of ice‐stream retreat in the past, present, and future should therefore be expected to vary significantly.
How I Started Living a Double Life in Psychological Science
Authors: Magnussen Svein 
Published: November 2013

SummaryMy personal history as an applied cognitive psychology researcher is short, dating 15 years back when I became aware of the field of eyewitness psychology, hitherto neglected in Norway. This short paper describes the development of eyewitness psychology in Norway, which, not accidentally, parallels the development of my own interests in this important field of applied cognitive psychology. Copyright © 2013 John Wiley & Sons, Ltd.
Data‐driven bounded‐error fault detection
Authors: Suárez Fábrega Antonio J. , Bravo Caro José Manuel , Abad Herrera Pedro J. , Gasca Rafael M. 
Published: November 2013

SUMMARYIn this paper, a new data‐driven fault‐detection method is proposed. This method is based on a new nonparametric system identification approach, which constitutes the principal contribution to this work. The fault‐detection method is a parametric model‐free approach that can be applied to nonlinear systems that work at various operating points. Not only can the fault‐detection process be applied to the steady state of each operating point, but it can also be applied to the transient state resulting from a change in the operating point. In order to detect faults, the proposed method uses an interval predictor based on bounded‐error techniques. The utilization of techniques based on bounded error enables system uncertainties to be included in an explicit way. This in turn leads to the possibility of obtaining interval predictions of the behaviour of the system, which include information on the reliability of the prediction itself. In order to show the effectiveness of the fault‐detection method, two examples are presented: in the form of a simulated process (counter‐flow shell‐and‐tube heat‐exchanger system) and an example of a real application (two‐tanks system). A comparison with two fault‐detection methods has also been included. Copyright © 2013 John Wiley & Sons, Ltd.
A novel germline PIGA mutation in Ferro‐Cerebro‐Cutaneous syndrome: A neurodegenerative X‐linked epileptic encephalopathy with systemic iron‐overload
Authors: Swoboda Kathryn J. , Margraf Rebecca L. , Carey John C. , Zhou Holly , Newcomb Tara M. , Coonrod Emily , Durtschi Jacob , Mallempati Kalyan , Kumanovics Attila , Katz Ben E. , Voelkerding Karl V. , Opitz John M. 
Published: November 2013

AbstractThree related males presented with a newly recognized x‐linked syndrome associated with neurodegeneration, cutaneous abnormalities, and systemic iron overload. Linkage studies demonstrated that they shared a haplotype on Xp21.3–Xp22.2 and exome sequencing was used to identify candidate variants. Of the segregating variants, only a PIGA mutation segregated with disease in the family. The c.328_330delCCT PIGA variant predicts, p.Leu110del (or c.1030_1032delCTT, p.Leu344del depending on the reference sequence). The unaffected great‐grandfather shared his X allele with the proband but he did not have the PIGA mutation, indicating that the mutation arose de novo in his daughter. A single family with a germline PIGA mutation has been reported; affected males had a phenotype characterized by multiple congenital anomalies and severe neurologic impairment resulting in infantile lethality. In contrast, affected boys in the family described here were born without anomalies and were neurologically normal prior to onset of seizures after 6 months of age, with two surviving to the second decade. PIGA encodes an enzyme in the GPI anchor biosynthesis pathway. An affected individual in the family studied here was deficient in GPI anchor proteins on granulocytes but not erythrocytes. In conclusion, the PIGA mutation in this family likely causes a reduction in GPI anchor protein cell surface expression in various cell types, resulting in the observed pleiotropic phenotype involving central nervous system, skin, and iron metabolism. © 2013 Wiley Periodicals, Inc.