bluuebunny/crossref_metadata_2025_split huggingface dataset:
Functional Testing Differences in Anterior Cruciate Ligament Reconstruction Patients Released Versus Not Released to Return to Sport
Authors: Mayer Stephanie W. , Queen Robin M. , Taylor Dean , Moorman Claude T. , Toth Allison P. , Garrett William E. , Butler Robert J. 
Published: April 2015

Background: No standardized return-to-activity or sport guidelines currently exist after anterior cruciate ligament (ACL) reconstruction. Isokinetic testing and unilateral hop testing, which have construct validity, are often used to make the determination of when a patient is ready to return to sport. Neither of these measures has been reported to be predictive of subsequent injuries. Purpose: To compare the performance on 2 functional tests of ACL reconstruction patients released to return to activity versus those who have not been released based on clinical impairment measures. Study Design: Cohort study; Level of evidence, 3. Methods: A total of 98 patients were examined by the treating orthopaedic surgeon 6 months after ACL reconstruction for traditional impairment measures, including swelling, range of motion, strength, and graft stability. After this examination, all subjects completed the functional testing, consisting of the Functional Movement Screen (FMS) and the Lower Quarter Y Balance Test (YBT-LQ), by an experienced tester who was blinded to the results of the clinical examination. On the basis of the clinical examination, all patients were grouped as being ready to return to sport or not being ready. Performance on the functional tests, as measured by overall performance and side-to-side asymmetry, was compared between the 2 groups using independent-samples t tests ( P < .05). Results: No difference existed between the groups with regard to the descriptive characteristics, with the exception that the group not cleared was younger (21.0 ± 7.4 years) than the group that was cleared (25.6 ± 13.2 years). Performance on the YBT-LQ revealed that no differences existed between groups when examining reach symmetry for any of the reach directions. In addition, no differences were found between groups when looking at the average reach score normalized to limb length for either the surgical or nonsurgical leg. Patients in the cleared group exhibited a similar score on the FMS (12.7 ± 2.9) compared with the noncleared group (12.8 ± 2.7). Similarly, no differences were observed for the number of asymmetries; however, both groups averaged 1 asymmetry during the testing. Conclusion: Clinical impairment measures do not appear to be related to measured functional ability. Performance on both functional tests, the FMS and YBT-LQ, at 6 months would suggest that the typical patient in both groups would be at a greater risk of lower extremity injury, based on currently published research.
Comparison of Outcomes for Osteochondral Lesions of the Talus With and Without Chronic Lateral Ankle Instability
Authors: Lee Moses , Kwon Ji Won , Choi Woo Jin , Lee Jin Woo 
Published: April 2015

Background: Previous reports suggest that prolonged instability of the ankle may contribute to development of osteochondral lesions and eventually lead to osteoarthritis. However, no studies have directly compared osteochondral lesions in ankles with chronic lateral ankle instability (CLAI) to those without instability. This study was performed to determine characteristics and resulting clinical outcomes associated with osteochondral lesions of the talus (OLT) in patients with and without instability. Methods: Of 420 patients who underwent primary arthroscopic marrow stimulation for OLT, 74 patients were identified as having concomitant CLAI. After considering age, sex, body mass index, and initial trauma history for the propensity score (1:2 ratio), a total of 148 patients without CLAI were matched from the remainder of the cohort. Demographics and lesion characteristics were compared using preoperative magnetic resonance imaging (MRI) and arthroscopy. Clinical outcomes were compared using a visual analog scale (VAS), the American Orthopaedic Foot & Ankle Society (AOFAS) ankle score, and the Foot and Ankle Outcome Score (FAOS). Results: The OLT group with CLAI presented a significantly increased proportion of lateral-side OLT, large OLT (150 mm2 or larger), and chondral lesions at the tip of the medial malleolus ( P = .018, P = .024, and P < .001, respectively). VAS and AOFAS scores were comparable at the last follow-up. However, the OLT with CLAI group also exhibited a significantly increased proportion of failure (AOFAS score less than 80) and inferior outcomes in the FAOS for the sport and recreation subscale ( P = .034 and P = .005, respectively). Conclusions: Compared with osteochondral lesions in ankles without CLAI, osteochondral lesions in an unstable ankle had an increased proportion of larger lesions (150 mm2 or larger) and additional chondral lesions at the tip of the medial malleolus and the tibia plafond. This group also displayed increased clinical failure (AOFAS score less than 80). Inferior performance in sport and recreational activities may be more likely in patients with both OLT and CLAI. Level of Evidence: Level III, retrospective cohort study.
Angiotensin-converting enzyme I/D polymorphism and acute respiratory distress syndrome
Authors: Deng Xingqi , Zhang Shaokun , Jin Kun , Li Lanyan , Gu Wei , Liu Mei , Zhou Ling 
Published: April 2015

Background: Some studies have assessed the association between angiotensin-converting enzyme (ACE) I/D polymorphism and acute respiratory distress syndrome (ARDS) risk. However, the results have been inconclusive and contradictory. Therefore, we performed a meta-analysis to investigate the association between ACE I/D polymorphism and ARDS risk. Methods: All relevant studies were searched using PubMed and EMBASE. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated using random-effects models or fixed-effects models. Results: A total of 14 studies with 5218 subjects were included in this meta-analysis. We found that ACE I/D polymorphism significantly associated with an increased ARDS risk (OR=1.57; 95% CI 1.30–1.89; P<0.00001). In the subgroup analysis by race, Caucasians with ACE I/D polymorphism showed increased ARDS risk (OR=1.63; 95% CI 1.32–2.02; P<0.00001). However, Asians with this polymorphism did not show significantly increased ARDS risk (OR=1.31; 95% CI 0.90–1.90; P=0.95). In the subgroup analysis by age group, adults showed increased ARDS risk (OR=1.60; 95% CI 1.32–1.93; P<0.00001), while pediatric patients did not have increased ARDS risk (OR=1.15; 95% CI 0.57–2.30; P=0.70). Conclusions: This meta-analysis suggested that ACE I/D polymorphism might contribute to the susceptibility for ARDS.
The biology and management of systemic anaplastic large cell lymphoma
Authors: Hapgood Greg , Savage Kerry J. 
Published: April 2015

AbstractSystemic anaplastic large cell lymphoma (ALCL) is an aggressive CD30+ non-Hodgkin lymphoma. Anaplastic lymphoma kinase–positive (ALK+) ALCL is associated with the NPM-ALK t(2;5) translocation, which is highly correlated with the identification of the ALK protein by immunohistochemistry. ALK+ ALCL typically occurs in younger patients and has a more favorable prognosis with 5-year survival rates of 70% to 90% in comparison with 40% to 60% for ALK-negative (ALK−) ALCL. Studies support young age as a strong component of the favorable prognosis of ALK+ ALCL. Until recently, no recurrent translocations were identified in ALK− ALCL. However, emerging data now highlight that ALK− ALCL is genetically and clinically heterogeneous with a subset having either a DUSP22 translocation and a survival rate similar to ALK+ ALCL or a less common P63 translocation, the latter associated with an aggressive course. Anthracycline-based regimens such as cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) remain the standard first-line treatment choice for systemic ALCL, but in many patients with ALK− ALCL, it is ineffective, and thus it is often followed by consolidative autologous stem cell transplantation. However, selection of appropriate patients for intensified therapy remains challenging, particularly in light of genetic and clinical heterogeneity in addition to the emergence of new, effective therapies. The antibody drug conjugate brentuximab vedotin is associated with a high response rate (86%) and durable remissions in relapsed/refractory ALCL and is under investigation in the first-line setting. In the future, combining clinical and genetic biomarkers may aid in risk stratification and help guide initial patient management.
Novel thin-GaN LED structure adopted micro abraded surface to compare with conventional vertical LEDs in ultraviolet light
Authors: Chiang Yen Chih , Lin Chien Chung , Kuo Hao Chung 
Published: April 2015

Abstract
In this study, novel thin-GaN-based ultraviolet light-emitting diodes (NTG-LEDs) were fabricated using wafer bonding, laser lift-off, dry etching, textured surface, and interconnection techniques. Placing PN electrodes on the same side minimized the absorption caused by electrodes in conventional vertical injection light-emitting diodes (V-LEDs) and the current spreading was improved. The light output power (700 mA) of the NTG-LEDs was enhanced by 18.3% compared with that of the V-LEDs, and the external quantum efficiency (EQE) of the NTG-LEDs was also relatively enhanced by 20.0% compared with that of a reference device. When the current operations were 1,500 mA, the enhancements of the light output power and EQE were 27.4% and 27.2%, respectively. Additionally, the efficiency droop was improved by more than 15% at the same current level.
The dynamics of monocytes and microglia in Alzheimer’s disease
Authors: Thériault Peter , ElAli Ayman , Rivest Serge 
Published: April 2015

AbstractAlzheimer’s disease (AD) is the most common neurodegenerative disorder affecting older people worldwide. It is a progressive disorder mainly characterized by the presence of amyloid-beta (Aβ) plaques and neurofibrillary tangles within the brain parenchyma. It is now well accepted that neuroinflammation constitutes an important feature in AD, wherein the exact role of innate immunity remains unclear. Although innate immune cells are at the forefront to protect the brain in the presence of toxic molecules including Aβ, this natural defense mechanism seems insufficient in AD patients. Monocytes are a key component of the innate immune system and they play multiple roles, such as the removal of debris and dead cells via phagocytosis. These cells respond quickly and mobilize toward the inflamed site, where they proliferate and differentiate into macrophages in response to inflammatory signals. Many studies have underlined the ability of circulating and infiltrating monocytes to clear vascular Aβ microaggregates and parenchymal Aβ deposits respectively, which are very important features of AD. On the other hand, microglia are the resident immune cells of the brain and they play multiple physiological roles, including maintenance of the brain’s microenvironment homeostasis. In the injured brain, activated microglia migrate to the inflamed site, where they remove neurotoxic elements by phagocytosis. However, aged resident microglia are less efficient than their circulating sister immune cells in eliminating Aβ deposits from the brain parenchyma, thus underlining the importance to further investigate the functions of these innate immune cells in AD. The present review summarizes current knowledge on the role of monocytes and microglia in AD and how these cells can be mobilized to prevent and treat the disease.
Effect of the curing process on the transverse tensile strength of fiber-reinforced polymer matrix lamina using micromechanics computations
Authors: D’Mello Royan J , Maiarù Marianna , Waas Anthony M 
Published: April 2015

AbstractThe effect of the curing process on the mechanical response of fiber-reinforced polymer matrix composites is studied using a computational model. Computations are performed using the finite element (FE) method at the microscale where representative volume elements (RVEs) are analyzed with periodic boundary conditions (PBCs). The commercially available finite element (FE) package ABAQUS is used as the solver, supplemented by user-written subroutines. The transition from a continuum to damage/failure is effected by using the Bažant-Oh crack band model, which preserves mesh objectivity. Results are presented for a hexagonally packed RVE whose matrix portion is first subjected to curing and subsequently to mechanical loading. The effect of the fiber packing randomness on the microstructure is analyzed by considering multi-fiber RVEs where fiber volume fraction is held constant but with random packing of fibers. The possibility of failure is accommodated throughout the analysis—failure can take place during the curing process prior to the application of in-service mechanical loads. The analysis shows the differences in both the cured RVE strength and stiffness, when cure-induced damage has and has not been taken into account.
Gastric Emptying Is More Rapid in Adolescents With Type 1 Diabetes and Impacts on Postprandial Glycemia
Authors: Perano Shiree J. , Rayner Chris K. , Kritas Stamatiki , Horowitz Michael , Donaghue Kim , Mpundu-Kaambwa Christine , Giles Lynne , Couper Jenny J. 
Published: April 2015

Context:
Gastric emptying is a critical determinant of postprandial glycemic control in health and type 1 diabetes. There are few studies that assess the relationship between gastric emptying and postprandial glycaemia in adolescents with type 1 diabetes.

Objective:
The objectives of the study were to quantify gastric emptying in adolescents with type 1 diabetes and examine its relationship to postprandial glycaemia and autonomic function.

Design:
This was a case-control study. Gastric half-emptying time of a solid meal was measured by a 13C-octanoate breath test. Cardio-autonomic function was measured by heart rate variability. Chronic and postprandial gastrointestinal symptoms were evaluated by questionnaire and visual analog scales. Blood glucose concentrations were monitored frequently during the study.

Setting:
The study was conducted at a tertiary pediatric hospital in South Australia.

Participants:
Thirty adolescents (aged 15 ± 2.5 y) with type 1 diabetes and age- and sex-matched controls (gastric emptying, n = 20; heart rate variability, n = 135) participated in the study.

Main Outcome:
Gastric half-emptying time was the main outcome in the study.

Results:
Gastric emptying was more rapid in subjects with type 1 diabetes than controls [median half emptying time 78 (interquartile range 61–99) vs 109 (interquartile range 71–124) min, P = .02]. The postprandial rise in blood glucose at 60 minutes was strongly related to gastric half-emptying time (R = −0.65, P = .0001). Gastric emptying was slower in subjects with fasting hyperglycemia but was not related to heart rate variability. Nausea, bloating, and anxiety were related to fasting glycemia (P = .03).

Conclusion:
Rapid gastric emptying is a major determinant of postprandial glycemia in adolescents with type 1 diabetes. This observation has significant implications for therapy.
Structural Isomerization and Cold Crystallization of Bis[1-(2-propyl)iminomethylnaphthalen-2-olato]nickel(II) by Thermal Analysis, X-ray Diffraction, and FT-IR
Authors: Iwase Katsunori , Yoshikawa Isao , Houjou Hirohiko , Yamamura Yasuhisa , Saito Kazuya 
Published: April 2015

Abstract
Two coordination isomers, i.e., square planar and pseudo-tetrahedral forms of the title compound, were crystallographically identified and discussed in relation to their thermal behavior revealed by XRD-DSC and FTIR-DSC. Upon the fusion, the coordination geometry partly changes, resulting in the liquid, which is an equilibrium mixture of molecules with the two coordination geometries. In this system, the mixed nature of liquid, in addition to molecular flexibility, is responsible for realization of large supercooling and glass transition, both of which enables the cold crystallization.
Indirect Estimation of Pediatric Between-Individual Biological Variation Data for 22 Common Serum Biochemistries
Authors: Loh Tze Ping , Metz Michael Patrick 
Published: April 2015

Abstract

Objectives:
Derivation of between-individual biological variation (CVg) data requires repeat sampling of the same subject, which is undesirable and challenging in children. We describe an indirect sampling (data mining) approach to obtain these data in children.

Methods:
Twenty-two serum biochemistry results from 6,989 children, who visited their primary care physician in Queensland, Australia, and were tested only twice within a year were included. The CVg and index of individuality of the boys and girls were estimated by year of age, according to the procedures recommended by Fraser and Harris.

Results:
The CVg was generally higher during the first year of life and declined to reach a constant level by age 4 to 6 years, except for aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, and phosphate. The CVg for these tended to increase after age 10 years. Most of the serum biochemistries examined in this study had indices of individuality 0.6 or less, except sodium, anion gap, bicarbonate, and chloride, which ranged from 0.6 to 1.4. The indices of individuality were very stable across all ages.

Conclusions:
These data are comparable to those reported by the Canadian Laboratory Initiative on Pediatric Reference Intervals study and the Ricos database for adults. This study reports the CVg trends and data for boys and girls by year of age, which have not been described previously.
Impact of a Prospective Review Program for Reference Laboratory Testing Requests
Authors: Greenblatt Matthew B. , Nowak Jonathan A. , Quade Cathleen C. , Tanasijevic Milenko , Lindeman Neal , Jarolim Petr 
Published: April 2015

Abstract

Objectives:
To control the cost of reference laboratory testing, to ensure that its usage is medically appropriate, and to review the contribution of reference testing to patient care at our institution.

Methods:
A multidisciplinary institutional committee was convened to manage the utilization of reference testing. A subset of tests was designated to be reviewed in real time by a team of clinical pathologists in consultation with clinical subject matter experts.

Results:
Twelve percent of testing requests, accounting for approximately 18% of send-out costs, were determined to be clinically unnecessary or would not produce actionable results at that point during that patient’s care and were therefore not performed. This intervention, combined with insourcing of frequently requested tests, resulted in a reduction in the costs of reference testing to less than half of that predicted by the rate of growth from 2005 to 2009. Molecular diagnostic tests displayed a higher cost per test than other forms of testing but had a similar degree of clinical impact.

Conclusions:
Formal prospective review of reference laboratory testing requests resulted in substantial cost containment and improved the efficiency of patient care.
Evaluating nursing students clinic stress, and coping with stress during the clinic first day of the Woman Health and Diseases Nursing clinical course
Authors: Coşkuner Potur Dilek , Çitak Bilgin Nevin , Kömürcü Nuran 
Published: April 2015

<p class="Standard"><strong>Purpose: </strong>This study aimed to explore the clinical stress levels, stress sources and coping strategies of Turkish male and female nursing students attending the Woman’s Health and Disease Nursing clinical course on the first day.</p><p class="Standard"><strong>Method and material:</strong> This cross-sectional study was conducted in March 2010 at a public university located in Istanbul. The study group included 98 nursing students. Data were collected from the nursing students in the study group using a self-report questionnaire, clinical stress questionnaire and Carver Coping scale. The data were analyses using percentages, chi-square analysis, the Mann-Whitney U test and Cronbach's alpha coefficients<strong> </strong></p><p class="Standard"><strong>Results: </strong>Approximately half of the male students (47.6%) reported that they experienced stress since the patient group consisted of females and the majority of male students (76.2%) stated that they were subject to gender discrimination at the clinic and there was a significant difference between the male and female students. The male and female nursing students’ stress levels and Carver Coping scale total score of on the first day of the Woman’s Health and Disease nursing clinical course was similar (p&gt;0.05). </p><p><strong>Conclusions: </strong> Male students experience stress because the patient group consisted of women, the majority of male students reported that they were subject to gender discrimination and gender discrimination was a source of stress for them. Female and male nursing<strong> </strong>students experienced stress in the first day of the clinical course of the Woman's Health and Diseases Nursing course, and that the stressors and coping strategies were similar across genders. In the clinical training for the Woman's Health and Diseases Nursing course lectures should be aware of possible stressors and, if necessary, should help students in positive coping.</p>
A Turkish adaptation of the Emotion Regulation Questionnaire
Authors: Eldeleklioğlu Jale , Eroğlu Yüksel 
Published: April 2015

<p>This study aimed to adapt the Emotional Regulation Questionnaire into Turkish and investigate its validity and reliability. The Turkish version of the Emotion Regulation Questionnaire was administered to 442 university students. Firstly, language equivalence of the Turkish version the Emotional Regulation Questionnaire was investigated and findings indicated that the Turkish translation of the Emotion Regulation Questionnaire is equivalent to the original form. Confirmatory factor analyses successfully revealed the two-factor (reappraisal and suppression) structure of the Turkish version the Emotional Regulation Questionnaire. Further, based on the two-factor model, results from multi-group analysis indicated that the Turkish version of the Emotional Regulation Questtionnaire has the property of strict factorial invariance across gender, including equal factor loadings, equal item intercepts, and equal item uniqueness (error variances and covariances). The internal consistencies were .78 for the reappraisal and .73 for the suppression subscales. Test-retest reliabilities were .74 for the reappraisal and .72 for the suppression subscales. Overall, the Turkish version of the Emotional Regulation Questionnaire has adequate psychometric properties and can be used to examine emotion regulation among Turkish university students. </p>
Von der Sinntheorie zur Ontologie. Zum Verständnis des Spätwerks Paul Tillichs
Authors: Dienstbeck Stefan 
Published: April 2015

ZusammenfassungDas theologisch-religionsphilosophische Werk Paul Tillichs stellt einen der größten und gegenwartsrelevantesten Systementwürfe im 20. Jahrhundert dar. Gerade mit den neu- und teilweise erstmals entdeckten und edierten frühen Schriften Tillichs verbindet sich die Frage nach der Konsistenz des Tillich’schen Lebenswerks. Insbesondere die in Deutschland angefertigten Beiträge Tillichs gelten in der heutigen Forschung als dem Spätwerk qualitativ überlegen. Doch ist das Spätwerk Tillichs tatsächlich so aporiebehaftet, wie an mancher Stelle gelesen werden kann? Lässt sich Tillichs spätes und bekanntestes Werk auch anders interpretieren? Der Beitrag versucht die Konsistenz der Tillich’schen Theologie unter Zuhilfenahme einer Gesamtdeutung des Oeuvres Tillichs anzudenken.