bluuebunny/crossref_metadata_2025_split huggingface dataset:
Triiodothyronine levels in relation to mortality from breast cancer and all causes: a population-based prospective cohort study
Authors: Tosovic Ada , Bondeson Anne-Greth , Bondeson Lennart , Ericsson Ulla-Britt , Manjer Jonas 
Published: December 2012

ObjectiveThe potential association between thyroid hormones and breast cancer has been investigated in a large number of studies without conclusive results. This study investigated triiodothyronine (T3) levels in relation to breast cancer mortality in a population with no breast cancer patients at baseline. An additional aim was to study T3levels in relation to mortality from other cancers and all-cause mortality.Design and methodsThis was a population-based prospective cohort study including 2185 women in whom T3levels were measured as part of a preventive health project, i.e. before diagnosis in women who later developed breast cancer. Mean follow-up was 24.1 years and record-linkage to The Swedish Cause-of-Death registry identified 471 women who died: 26 out of breast cancer and 182 from other cancers. Mortality was assessed using a Cox's analysis, yielding hazard ratios (HRs), with 95% confidence intervals. Analyses of T3as a continuous variable were repeated for pre- and peri/postmenopausal women separately.ResultsT3levels were positively associated with the risk of breast cancer-specific death in the age-adjusted analysis: HR for T3as a continuous variable was 2.80 (1.26–6.25). However, the crude analysis did not reach statistical significance. Breast cancer mortality was even higher in postmenopausal women: 3.73 (1.69–8.22), but stratified analyses included few events. There were no statistically significant associations between T3levels and deaths from other cancers, age-adjusted HR: 1.09 (0.72–1.65) or all-cause mortality (1.25:0.97–1.60).ConclusionsThis study, the first of its kind on prospectively measured T3levels, indicates that T3levels are positively associated with breast cancer-specific mortality and that this is not related to a general effect on all-cause mortality.
Plasma 25‐Hydroxyvitamin D Concentrations and Periodontal Disease in Postmenopausal Women
Authors: Millen Amy E. , Hovey Kathleen M. , LaMonte Michael J. , Swanson Mya , Andrews Christopher A. , Kluczynski Melissa A. , Genco Robert J. , Wactawski‐Wende Jean 
Published: December 2012

Background: Vitamin D has anti‐inflammatory and antimicrobial properties that, together with its influence on bone health, may confer periodontal benefit.Methods: Cross‐sectional associations (years 1997‐2000) between plasma 25‐hydroxyvitamin D concentration [25(OH)D] and periodontal measure were investigated among 920 postmenopausal women. Measures of chronic disease were defined based on: 1) alveolar crestal height (ACH) measures from intraoral radiographs and tooth loss and 2) Centers for Disease Control and Prevention (CDC)/American Academy of Periodontology (AAP) criteria using measures of clinical attachment level and probing depth (PD). Acute oral inflammation was assessed by the percentage of gingival sites that bled upon assessment with a probe. Logistic regression was used to estimate the odds ratios (ORs) and 95% confidence intervals (CIs) for periodontal disease among participants with adequate [25(OH)D ≥50 nmol/L] compared with deficient/inadequate [25(OH)D <50 nmol/L] vitamin D status adjusted for age, dental visit frequency, and body mass index.Results: No association was observed between vitamin D status and periodontal disease defined by ACH and tooth loss (adjusted OR = 0.96, 95% CI = 0.68 to 1.35). In contrast, women with adequate compared with deficient/inadequate vitamin D status had 33% lower odds (95% CI = 5% to 53%) of periodontal disease according to the CDC/AAP definition and 42% lower odds (95% CI = 21% to 58%) of having ≥50% of gingival sites that bled.Conclusions: Vitamin D status was inversely associated with gingival bleeding, an acute measure of oral health and inflammation, and inversely associated with clinical categories of chronic periodontal disease that incorporated PD, an indicator of oral inflammation. However, vitamin D was not associated with chronic periodontal disease based on measures of ACH in combination with tooth loss.
Budgetary Participation in Turkey: The Effects of Information Asymmetry, Goal Commitment, and Role Ambiguity on Job Satisfaction and Performance
Authors: Jermias Johnny , Yigit Fatih 
Published: December 2012

ABSTRACT
This study empirically investigates the antecedent, mediating, and outcome variables of budgetary participation in Turkey. Turkey is an interesting setting to investigate the impact of budgetary participation on job satisfaction and performance because of its unique cultural and institutional factors. We propose that the information asymmetry between superiors and subordinates creates the need for budgetary participation, and the outcomes of budgetary participation (i.e., job satisfaction and performance) will be mediated by goal commitment and role ambiguity.
Based on a questionnaire survey of 194 mid-level managers in Turkey, we find that role ambiguity mediates the budgetary participation–job satisfaction and budgetary participation-performance relationships. The results are consistent with the view that the primary benefit of budgetary participation is to decrease role ambiguity, leading to more job satisfaction and better performance. Furthermore, we find that goal commitment mediates the budgetary participation-performance relationship. This result suggests that participation in the budgeting process increases goal commitment, which in turn leads to better performance. This study will be beneficial for companies in general and for organizations in developing countries in particular to realize that budgetary participation alone does not improve job satisfaction and performance. Rather, it is the increased commitment and decreased role ambiguity that results from managers' participation in the budgetary process that improves job satisfaction and performance.
JEL Classifications: D21, G32, L1, M41.
Travestir (en) los límites : identidades transitivas en el discurso neobarroco de la neovanguardia latinoamericana
Authors: Kulawik Krzysztof 
Published: December 2012

La presencia del travestismo y la androginia en las obras de los autores y artistas visuales hispanoamericanos contemporáneos Severo Sarduy, Pedro Lemebel, Eugenia Prado, Roberto Echavarren y Gloria Anzaldúa indica cambios en la percepción y representación de la identidad como categoría cultural. En sus obras, a veces referidas como neovanguardistas o neobarrocas, aparecen personajes cambiantes e inestables, los que pueden llamarse « sujetos transitivos » o « nómadas ». Su presencia inquietante lleva a deconstruir y reformular las categorías culturales fijas como sexo, etnia, raza y nación. Su análisis ayuda a adelantar una teoría de identidad cultural basada en la ambigüedad del travesti y el andrógino con apariencias cambiantes, en un juego camaleónico con la otredad. Esta teoría puede aplicarse al estudio de los grupos y sujetos culturales emergentes en el híbrido contexto cultural latinoamericano. Demuestra la presencia de la otredad en cada unidad, de la alteridad en cada identidad. Los sujetos discursivos y personajes de las obras analizadas representan una resistencia política y cultural a las normas del sistema patriarcal y neocolonial impuesto por el establecimiento económico, cultural y mediático neoliberal. Son sujetos híbridos, transitivos y transgresivos que encarnan el contexto multi- y transcultural posmoderno de Latinoamérica.
Con Sangre en el ojo : para una escritura de resistencia
Authors: Voionmaa Daniel Noemi 
Published: December 2012

This article studies the novel Sangre en el ojo (2012) (Blood in the Eye), by Chilean writer Lina Meruane. First, it argues about the distinction between resistance literature and resistance writing. As an example of the latter, the novel by Meruane presents a variety of narrative strategies or writing devices that contribute to create an ethics and aesthetics of resistance. The relevance of the body and in particular of the eyesight is highlighted. The novel allows us to think the possibility of a different gaze and visualization of reality ; one that breaks from the view/gaze imposed by the system/hegemony.
El beso de la mujer araña metáfora performativa
Authors: Medel - Bao Jordi 
Published: December 2012

Si partimos de la evidencia de que para interpretar cualquier producción cultural es necesario atender a las metáforas performativas que utiliza y a la realidad que las mismas han intentado describir, el presente artículo analiza desde el punto de vista de los estudios culturales los aspectos que aúnan las relaciones entre la sexualidad o el deseo de los personajes y la relación establecida con la representación política en el interior del panóptico por excelencia de la prisión (según la terminología de Foucault).Vemos el texto como experiencia estética contra una situación traumática para la sociedad que atraviesa las fronteras de clase y de sexualidad al mismo tiempo y que critica las imposiciones del poder de la dictadura militar argentina. Dado que la novela se publica en 1975 y la película se estrena en 1985 es de toda evidencia que los problemas representados eran de máxima actualidad : Puig había vuelvo a Argentina bajo la presidencia de Onganía en 1967 pero tiene que volver a exiliarse en 1973. En ese momento ya había empezado a trabajar en el libro realizando entrevistas a los presos políticos que habían sido liberados por el gobierno peronista de Héctor Cámpora.La censura prohibió el texto por considerar que atentaba contra la Nación pero no pudieron impedir que circularan textos “ilegales” y que la novela llegara hasta la actualidad para ayudarnos a “releer el pasado” bajo la óptica queer.
Politique et sexualité : les femmes dans les romans du dictateur
Authors: Brochard Cécile 
Published: December 2012

Nous abordons la figure féminine et ses rapports avec le pouvoir dictatorial à travers trois romans : Madama Sui d’Augusto Roa Bastos, où l’héroïne est la maîtresse de Stroessner, Santa Evita de Tomás Eloy Martínez, roman consacré à Evita Perón, figure célèbre de la dictature péroniste, et El otoño del patriarca de Gabriel García Márquez. Le rapport des femmes aux dictateurs y est d’abord un rapport d’assujettissement : soumission au pouvoir absolu, jusqu’à la forme radicale et tragique qu’est la mort. Mais au-delà de ce rapport générique marquant la supériorité physique et sociale de l’homme sur la femme, c’est l’émergence de figures féminines fascinantes qui retient ces romanciers : à travers le statut d’icône de ces femmes, à travers les fantasmes collectifs qu’elles ont suscités, les romans réfléchissent ainsi à la manière dont se sont créés ces mythes féminins intimement liés au pouvoir.
La construction du genre et de la sexualité au Mexique
Authors: Avalos Romero Job 
Published: December 2012

L’article analyse la construction de l’identité à travers les conversations entre amis dans un petit groupe de lycéens. Le sujet ici proposé cherche à montrer comment un groupe d’amis dans un lycée public à Mexico, expérimente les relations de genre et quels sont leurs discours sur le flirt, les relations amoureuses et leur expérience de la sexualité. On peut citer, entre autres, les résultats suivants : 1. Un changement d’attitude des hommes et des femmes par rapport aux relations de genre. Les filles se montrent libres d’essayer plusieurs liens affectifs (un comportement considéré au Mexique comme typiquement masculin) et d’avoir une vie sexuelle détachée de l’affection sans pour autant aboutir à un conflit moral. De leur côté, même si les garçons gardent quelques traits du rôle masculin traditionnellement imposé, ils semblent ouverts à explorer leur côté émotionnel dans leurs relations amoureuses. Ils paraissent, en même temps, moins intéressés par une sexualité centrée sur la génitalité. 2. De la même manière, un vrai processus de dénaturalisation de la sexualité semble s’installer chez les jeunes. Cette dénaturalisation implique le fait qu’être hétérosexuel n’est pas le seul moyen de vivre sa sexualité. La bisexualité et l’homosexualité sont aussi valides et légitimes pour ce groupe d’amis.
Regulation of TLR2-Mediated Tolerance and Cross-Tolerance through IRAK4 Modulation by miR-132 and miR-212
Authors: Nahid Md A. , Yao Bing , Dominguez-Gutierrez Paul R. , Kesavalu Lakshmyya , Satoh Minoru , Chan Edward K. L. 
Published: December 2012

Abstract
Innate immune response is the first defense against pathogens via recognition by various conserved pattern recognition receptors, such as TLRs, to initiate a rapid and strong cytokine alarm. TLR signaling–mediated cytokine production must be properly regulated to prevent pathological conditions deriving from overproduction of cytokines. In this study, the role of specific microRNAs in TLR-signaling pathway was investigated to reveal the cross-interaction and -regulation in the MyD88 pathway. In peptidoglycan (PGN)/TLR2–stimulated THP-1 monocytes, PBMCs, and primary macrophages showed rapid and dramatic miR-132 and miR-212 (miR-132/-212) upregulation. This newly identified response appeared earlier in time than the characteristic miR-146a response in LPS-TLR4 stimulation. The rapid induction of miR-132/-212 was transcription factor CREB dependent, and the sustained expression of miR-132/-212 was responsible for inducing tolerance to subsequent PGN challenge. Cross-tolerance was observed by TLR5 ligand flagellin and heat-killed or live bacteria resulting from miR-132/-212 upregulation. Mechanistically, IRAK4 was identified and validated as a target of miR-132/-212 by luciferase reporter assay and seed-sequence mutagenesis of the reporter. Transfection of miR-132 or miR-212 alone mimicked PGN tolerance in monocytes, whereas transfected specific miRNA inhibitors tampered the tolerance effect. During bacterial infection, PGN-mediated TLR2 signaling induces miR-132/-212 to downregulate IRAK4, an early component in the MyD88-dependent pathway, whereas LPS/TLR4-induced miR-146a downregulates downstream components of the same MyD88-dependent pathway. The identification of miR-132/-212 and miR-146a together to prevent damaging consequences from the overproduction of proinflammatory cytokines by targeting a common signaling pathway is significant and will provide insights into future design and development of therapeutics.
Chronic Exposure to Plasmodium falciparum Is Associated with Phenotypic Evidence of B and T Cell Exhaustion
Authors: Illingworth Joseph , Butler Noah S. , Roetynck Sophie , Mwacharo Jedida , Pierce Susan K. , Bejon Philip , Crompton Peter D. , Marsh Kevin , Ndungu Francis M. 
Published: December 2012

Abstract
Naturally acquired immunity to malaria develops slowly, requiring several years of repeated exposure to be effective. The cellular and molecular factors underlying this observation are only partially understood. Recent studies suggest that chronic Plasmodium falciparum exposure may induce functional exhaustion of lymphocytes, potentially impeding optimal control of infection. However, it remains unclear whether the “atypical” memory B cells (MBCs) and “exhausted” CD4 T cells described in humans exposed to endemic malaria are driven by P. falciparum per se or by other factors commonly associated with malaria, such as coinfections and malnutrition. To address this critical question we took advantage of a “natural” experiment near Kilifi, Kenya, and compared profiles of B and T cells of children living in a rural community where P. falciparum transmission is ongoing to the profiles of age-matched children living under similar conditions in a nearby community where P. falciparum transmission ceased 5 y prior to this study. We found that continuous exposure to P. falciparum drives the expansion of atypical MBCs. Persistent P. falciparum exposure was associated with an increased frequency of CD4 T cells expressing phenotypic markers of exhaustion, both programmed cell death-1 (PD-1) alone and PD-1 in combination with lymphocyte-activation gene-3 (LAG-3). This expansion of PD-1–expressing and PD-1/LAG-3–coexpressing CD4 T cells was largely confined to CD45RA+ CD4 T cells. The percentage of CD45RA+CD27+ CD4 T cells coexpressing PD-1 and LAG-3 was inversely correlated with frequencies of activated and classical MBCs. Taken together, these results suggest that P. falciparum infection per se drives the expansion of atypical MBCs and phenotypically exhausted CD4 T cells, which has been reported in other endemic areas.
Multi‐Autoantibody Testing Identifies Expansion of Reactivity to Targeted Antigens Before a Diagnosis of Rheumatoid Arthritis
Authors: Goff Salina H. , Bergstedt Dylan T. , Feser Marie L. , Moss LauraKay , Mikuls Ted R. , Edison Jess D. , Holers V. Michael , Martinez‐Prat Laura , Aure Mary Ann R. , Mahler Michael , Deane Kevin D. 
Published: July 2024

ObjectiveRheumatoid arthritis (RA) has a “pre‐RA” period in which multiple autoantibodies, including antibodies to citrullinated (cit) proteins (ACPA), rheumatoid factor (RF), anti–peptidyl arginine deiminase (anti‐PAD), among others, have been described; however, few studies have tested all autoantibodies in a single pre‐RA cohort. This study aims to evaluate the prevalence of multiple autoantibodies in pre‐RA and potentially identify an autoantibody profile in pre‐RA that indicates imminent onset of clinical RA.MethodsWe evaluated 148 individuals with two pre‐ and one post‐RA diagnosis samples available from the Department of Defense Serum Repository and matched controls. Samples were tested for immuglobulin (Ig) G anti–cyclic cit peptide‐3 (anti‐CCP3), five ACPA fine specificities, five anti‐PAD isoforms, as well as RF IgA and RF IgM using commercial platforms; cutoffs were determined using levels present in <1% of controls.ResultsPositivity of anti‐CCP3, RF IgA and RF IgM, anti‐PAD1, anti–cit‐vimentin 2, anti–cit‐fibrinogen, and anti–cit‐histone 1 increased over time in pre‐RA, although anti‐PAD and ACPA fine specificities were predominately present within anti‐CCP3–positive individuals. Within anti‐CCP3–positive samples from the pre‐RA period, positivity for RFs as well as anti‐PAD and ACPA fine specificities classified samples as being closer to the time of RA diagnosis.ConclusionMultiple autoantibodies are present in pre‐RA and increase in positivity as the time of RA diagnosis approaches. These results confirm previous findings predicting imminent RA and provide a pathway using commercial‐grade assays to assess the risk for and timing of development of clinical RA.
Quintuple Free‐Radical Therapy: An Ultralong‐Retention FAND for NIR‐Involved Multiple Site‐Acting Hypoxic Tumor Therapy
Authors: Zhang Chuang , Zhao Dongxu , Fang Fang , Zhu Lin , Li Weiyu , Wang Sa , Fan Yueyun , Yang Jiani , Liu Yanhong , Zhang Jinfeng 
Published: July 2024

AbstractThe heavy dependence on intratumoral O2 and H2O2 availability has greatly restricted ROS‐based therapy. Although O2/H2O2‐irrelevant free‐radical nanogenerator has garnered tremendous attention as a promising anticancer candidate to overcome the above intrinsic limitations of ROS‐based treatment, the practical therapeutic efficacy of free‐radical therapy is still hindered by limited free‐radical type and inferior tumor retention performance. Herein, inspired by the new concept of full‐API nanodrug (FAND) with 100% active pharmaceutical ingredient (API) content and repurposing of clinical anti‐malaria drug artesunate (ARTE) as an anticancer free‐radical generator, the AFeI FANDs composed of ARTE, human essential Fe3+, and FDA‐approved fluorescent agent ICG for hypoxic tumor therapy are rationally designed and constructed. Attractively, the completely pharmaceutically active components ARTE, Fe3+, and ICG can be responsively liberated in the acidic tumor microenvironment and synergistically produce five types of free radicals including •O2−, •C, •OH, LOO•, and 1O2, leading to robust mitochondrial injury, nuclear DNA damage, and lipid peroxides. More importantly, the AFeI FANDs displayed ultralong tumor retention longer than 108 h and favorable tumor suppression outcomes under mild NIR irradiation. Collectively, the presented first paradigm of FAND‐based quintuple free‐radical therapy expands new horizons for the development of clinically transferable nanomedicine for tumor therapy.
Passive Dosimeters for Radiation Dosimetry: Materials, Mechanisms, and Applications
Authors: Yang Zetian , Vrielinck Henk , Jacobsohn Luiz G. , Smet Philippe F. , Poelman Dirk 
Published: July 2024

AbstractPassive dosimeters enabling accurate measurement of doses from gamma rays to visible light are necessary to ensure efficient utilization of electromagnetic radiation in numerous fields like medical diagnostics and industrial manufacturing. The specific requirements for dosimeters in terms of dosimetry range, sensitivity, accuracy, and stability for each application have led to the development of various dosimeters based on new materials and new mechanisms. Here, a comprehensive review of different types of dosimeters classified according to the response signal, namely electron paramagnetic resonance, electrical, and optical, is provided. This review starts with a general introduction to dosimetry, a classification of dosimeters, and an elucidation of the necessity of dosimeters in various ranges of the electromagnetic spectrum. This is followed by an overview of the fundamental requirements of dosimeters, an explanation of the general dosimetry procedure, and the dosimetric quantities. Emphasis is given to the working mechanism, the design concept, and applications of each type of dosimeter as well as their respective strengths and drawbacks. Challenges and prospects are presented at the end of the review. This review provides an insightful overview of the material‐mechanism‐characteristics‐application relationship of different types of dosimeters that hopefully can serve as inspiration for the development of new devices.
Broad Light Absorption and Multichannel Charge Transfer Mediated by Topological Surface State in CdS/ZnS/Bi2Se3 Nanotubes for Improved Photocatalytic Hydrogen Production
Authors: Xiong Yu‐Tong , Liu Wei‐Xi , Tian Lin , Qin Ping‐Li , Chen Xiang‐Bai , Ma Liang , Liu Qing‐Bo , Ding Si‐Jing , Wang Qu‐Quan 
Published: July 2024

AbstractSemiconductor heterojunctions have garnered extensive interest in photocatalytic hydrogen generation, yet the limited light absorption and charge transfer efficiencies still restrict the photocatalytic performance. The topological insulator has unique surface states and high‐mobility electrons, demonstrating the significant potential for enhancing photocatalysis. Herein, a ternary photocatalyst based on a topological insulator, in which CdS and ZnS nanoparticles are grown on Bi2Se3 nanotube, is prepared for efficient photocatalysis driven by topological surface state for the first time. Under simulated solar light irradiation, the CdS/ZnS/Bi2Se3 nanotubes display a robust photocatalytic hydrogen production rate of 7.13 mmol h−1 g−1, which is 69.2 times of CdS and comparable to many CdS‐based photocatalysts. The unique hollow structure, topological surface state of Bi2Se3, and cooperative bandgap excitations of the three components endow the hybrids with wide light response to harvest solar energy. Meanwhile, the multichannel charge transfer facilitated by topological surface state and internal electric fields within the hybrids effectively suppresses the recombination of the photogenerated charge carriers. This mechanism maintains a high concentration of stable electrons on Bi2Se3, resulting in highly efficient hydrogen production. This work provides a new inspiration for designing heterojunction photocatalysts based on topological insulators for high‐efficiency solar‐driven energy conversion.