bluuebunny/crossref_metadata_2025_split huggingface dataset:
Dietary Intake and Ovarian Cancer Risk: A Systematic Review
Authors: Crane Tracy E. , Khulpateea Beman R. , Alberts David S. , Basen-Engquist Karen , Thomson Cynthia A. 
Published: October 2013

AbstractOvarian cancer is a leading cause of gynecological cancer death. There is a need to identify modifiable dietary risk factors for this disease. To evaluate the role of diet in ovarian cancer risk, we performed a PRISMA-directed systematic review that included prospective cohort studies with &gt;200 cases (n = 24). Higher risk for ovarian cancer was shown for total, animal, and dairy fat (five of nine studies), as well as total nitrate and possibly total vitamin C. No associations were demonstrated for red meat, fiber, vitamin A, vitamin E, β-carotene, or folate. Vegetables were associated with lower risk in one of three studies; fruit showed no association, although risk estimates were all greater than 1.0. Isoflavones and flavonoids were associated with modestly lower risk in two studies and tea intake was associated with lower risk in one of two studies. This review suggests that no specific dietary factors are consistently associated with ovarian cancer risk. Data by tumor subtypes are limited, but suggest that differential associations by tumor subtype may exist and should be evaluated. Studies of ample sample size, varied exposure, which can better control for dietary measurement error, are needed to fully define dietary recommendations for ovarian cancer prevention. Cancer Epidemiol Biomarkers Prev; 23(2); 255–73. ©2013 AACR.
The Histone Deacetylase Inhibitor Abexinostat Induces Cancer Stem Cells Differentiation in Breast Cancer with Low Xist Expression
Authors: Salvador Marion A. , Wicinski Julien , Cabaud Olivier , Toiron Yves , Finetti Pascal , Josselin Emmanuelle , Lelièvre Hélène , Kraus-Berthier Laurence , Depil Stéphane , Bertucci François , Collette Yves , Birnbaum Daniel , Charafe-Jauffret Emmanuelle , Ginestier Christophe 
Published: October 2013

Abstract
Purpose: Cancer stem cells (CSC) are the tumorigenic cell population that has been shown to sustain tumor growth and to resist conventional therapies. The purpose of this study was to evaluate the potential of histone deacetylase inhibitors (HDACi) as anti-CSC therapies.
Experimental Design: We evaluated the effect of the HDACi compound abexinostat on CSCs from 16 breast cancer cell lines (BCL) using ALDEFLUOR assay and tumorsphere formation. We performed gene expression profiling to identify biomarkers predicting drug response to abexinostat. Then, we used patient-derived xenograft (PDX) to confirm, in vivo, abexinostat treatment effect on breast CSCs according to the identified biomarkers.
Results: We identified two drug-response profiles to abexinostat in BCLs. Abexinostat induced CSC differentiation in low-dose sensitive BCLs, whereas it did not have any effect on the CSC population from high-dose sensitive BCLs. Using gene expression profiling, we identified the long noncoding RNA Xist (X-inactive specific transcript) as a biomarker predicting BCL response to HDACi. We validated that low Xist expression predicts drug response in PDXs associated with a significant reduction of the breast CSC population.
Conclusions: Our study opens promising perspectives for the use of HDACi as a differentiation therapy targeting the breast CSCs and identified a biomarker to select patients with breast cancer susceptible to responding to this treatment. Clin Cancer Res; 19(23); 6520–31. ©2013 AACR.
The Residual Tumor Autophagy Marker LC3B Serves as a Prognostic Marker in Local Advanced Breast Cancer after Neoadjuvant Chemotherapy
Authors: Chen Sheng , Jiang Yi-Zhou , Huang Liang , Zhou Ruo-Ji , Yu Ke-Da , Liu Yin , Shao Zhi-Ming 
Published: October 2013

AbstractPurpose: This study sought to investigate the prognostic value of the autophagy marker microtubule–associated protein chain 3B (LC3B) in patients with residual tumors after neoadjuvant chemotherapy (NCT) for locally advanced breast cancer (LABC).Patients and Methods: The expression of LC3B in residual breast cancer cells was assessed by immunohistochemistry in surgical specimens from 229 patients diagnosed with histologically proven invasive breast cancer. All patients underwent NCT followed by mastectomy and were considered nonpathologic complete responders (non-pCR) after a pathologic evaluation. The prognostic value of various clinicopathologic factors was evaluated.Results: The LC3B density was similar between the peripheral and central area of the tumors (P = 0.328) but was significantly lower in the extratumoral area (P &lt; 0.001 and P &lt; 0.001, respectively). Furthermore, LC3B density, which correlated with Beclin-1 expression, Ki-67 index, and breast cancer subtype, served as an independent prognostic factor for both relapse-free survival (RFS; P = 0.012) and overall survival (OS; P = 0.008); the prognostic value of LC3B was most significant in triple-negative patients. Using a combination of LC3B expression and the status of residual involved lymph nodes, the patients were classified into four groups with different risks of relapse and death (P &lt; 0.001 for RFS and P = 0.003 for OS).Conclusion: LC3B can be used as a prognostic marker in patients with non-pCR after NCT for breast cancer, which highlights the importance of autophagy in the biologic behavior of chemoresistant cancer cells. Furthermore, evaluating and targeting autophagy in the neoadjuvant setting may help prevent disease relapse in patients with non-pCR. Clin Cancer Res; 19(24); 6853–62. ©2013 AACR.
The Novel VEGF Receptor/MET–Targeted Kinase Inhibitor TAS-115 Has MarkedIn VivoAntitumor Properties and a Favorable Tolerability Profile
Authors: Fujita Hidenori , Miyadera Kazutaka , Kato Masanori , Fujioka Yayoi , Ochiiwa Hiroaki , Huang Jinhong , Ito Kimihiro , Aoyagi Yoshimi , Takenaka Toru , Suzuki Takamasa , Ito Satoko , Hashimoto Akihiro , Suefuji Takashi , Egami Kosuke , Kazuno Hideki , Suda Yoshimitsu , Nishio Kazuto , Yonekura Kazuhiko 
Published: October 2013

AbstractVEGF receptor (VEGFR) signaling plays a key role in tumor angiogenesis. Although some VEGFR signal-targeted drugs have been approved for clinical use, their utility is limited by associated toxicities or resistance to such therapy. To overcome these limitations, we developed TAS-115, a novel VEGFR and hepatocyte growth factor receptor (MET)-targeted kinase inhibitor with an improved safety profile. TAS-115 inhibited the kinase activity of both VEGFR2 and MET and their signal-dependent cell growth as strongly as other known VEGFR or MET inhibitors. On the other hand, kinase selectivity of TAS-115 was more specific than that of sunitinib and TAS-115 produced relatively weak inhibition of growth (GI50 &gt; 10 μmol/L) in VEGFR signal- or MET signal-independent cells. Furthermore, TAS-115 induced less damage in various normal cells than did other VEGFR inhibitors. These data suggest that TAS-115 is extremely selective and specific, at least in vitro. In in vivo studies, TAS-115 completely suppressed the progression of MET-inactivated tumor by blocking angiogenesis without toxicity when given every day for 6 weeks, even at a serum-saturating dose of TAS-115. The marked selectivity of TAS-115 for kinases and targeted cells was associated with improved tolerability and contributed to the ability to sustain treatment without dose reduction or a washout period. Furthermore, TAS-115 induced marked tumor shrinkage and prolonged survival in MET-amplified human cancer–bearing mice. These data suggest that TAS-115 is a unique VEGFR/MET-targeted inhibitor with improved antitumor efficacy and decreased toxicity. Mol Cancer Ther; 12(12); 2685–96. ©2013 AACR.
Targeting Sphingosine Kinase Induces Apoptosis and Tumor Regression for KSHV-Associated Primary Effusion Lymphoma
Authors: Qin Zhiqiang , Dai Lu , Trillo-Tinoco Jimena , Senkal Can , Wang Wenxue , Reske Tom , Bonstaff Karlie , Del Valle Luis , Rodriguez Paulo , Flemington Erik , Voelkel-Johnson Christina , Smith Charles D. , Ogretmen Besim , Parsons Chris 
Published: October 2013

Abstract
Sphingosine kinase (SPHK) is overexpressed by a variety of cancers, and its phosphorylation of sphingosine results in accumulation of sphingosine-1-phosphate (S1P) and activation of antiapoptotic signal transduction. Existing data indicate a role for S1P in viral pathogenesis, but roles for SPHK and S1P in virus-associated cancer progression have not been defined. Rare pathologic variants of diffuse large B-cell lymphoma arise preferentially in the setting of HIV infection, including primary effusion lymphoma (PEL), a highly mortal tumor etiologically linked to the Kaposi's sarcoma-associated herpesvirus (KSHV). We have found that ABC294640, a novel clinical-grade small molecule selectively targeting SPHK (SPHK2 &gt;&gt; SPHK1), induces dose-dependent caspase cleavage and apoptosis for KSHV+ patient-derived PEL cells, in part through inhibition of constitutive signal transduction associated with PEL cell proliferation and survival. These results were validated with induction of PEL cell apoptosis using SPHK2-specific siRNA, as well as confirmation of drug-induced SPHK inhibition in PEL cells with dose-dependent accumulation of proapoptotic ceramides and reduction of intracellular S1P. Furthermore, we demonstrate that systemic administration of ABC294640 induces tumor regression in an established human PEL xenograft model. Complimentary ex vivo analyses revealed suppression of signal transduction and increased KSHV lytic gene expression within drug-treated tumors, with the latter validated in vitro through demonstration of dose-dependent viral lytic gene expression within PEL cells exposed to ABC294640. Collectively, these results implicate interrelated mechanisms and SPHK2 inhibition in the induction of PEL cell death by ABC294640 and rationalize evaluation of ABC294640 in clinical trials for the treatment of KSHV-associated lymphoma. Mol Cancer Ther; 13(1); 154–64. ©2013 AACR.
Crizotinib, a c-Met Inhibitor, Prevents Metastasis in a Metastatic Uveal Melanoma Model
Authors: Surriga Oliver , Rajasekhar Vinagolu K. , Ambrosini Grazia , Dogan Yildrim , Huang Ruimin , Schwartz Gary K. 
Published: October 2013

Abstract
Uveal melanoma is the most common primary intraocular malignant tumor in adults and half of the primary tumors will develop fatal metastatic disease to the liver and the lung. Crizotinib, an inhibitor of c-Met, anaplastic lymphoma kinase (ALK), and ROS1, inhibited the phosphorylation of the c-Met receptor but not of ALK or ROS1 in uveal melanoma cells and tumor tissue. Consequently, migration of uveal melanoma cells was suppressed in vitro at a concentration associated with the specific inhibition of c-Met phosphorylation. This effect on cell migration could be recapitulated with siRNA specific to c-Met but not to ALK or ROS1. Therefore, we developed a uveal melanoma metastatic mouse model with EGFP–luciferase-labeled uveal melanoma cells transplanted by retro-orbital injections to test the effect of crizotinib on metastasis. In this model, there was development of melanoma within the eye and also metastases to the liver and lung at 7 weeks after the initial transplantation. When mice were treated with crizotinib starting 1 week after the transplantation, we observed a significant reduction in the development of metastases as compared with untreated control sets. These results indicate that the inhibition of c-Met activity alone may be sufficient to strongly inhibit metastasis of uveal melanoma from forming, suggesting crizotinib as a potential adjuvant therapy for patients with primary uveal melanoma who are at high risk for the development of metastatic disease. Mol Cancer Ther; 12(12); 2817–26. ©2013 AACR.
AKR1B10, a Transcriptional Target of p53, Is Downregulated in Colorectal Cancers Associated with Poor Prognosis
Authors: Ohashi Tomoko , Idogawa Masashi , Sasaki Yasushi , Suzuki Hiromu , Tokino Takashi 
Published: October 2013

Abstract
p53 is one of the most important tumor suppressor genes, and it is frequently inactivated in various cancers. p53 modulates various cellular functions, such as apoptosis and cell-cycle arrest via transcriptional regulation. Recently, p53 has been reported to be involved in a wide range of cellular metabolic pathways, including glycolysis, oxidative phosphorylation, glutaminolysis, and the antioxidant response. To understand the functional mechanism of p53, it is important to find out the direct transcriptional targets of p53. In this study, aldo-keto reductase family 1, member B10 (AKR1B10) was identified as a direct target of the p53 family by cDNA microarray analysis after comparing the mRNA expression of control and H1299 cells that overexpressed with p53 family members. In addition, we found that the expression of AKR1B10 was significantly decreased in colorectal cancers and adenomas as compared with normal colon tissues. Knockdown of AKR1B10 significantly inhibited p53-induced apoptosis in colorectal cancer cells, whereas the overexpression of AKR1B10 enhanced p53-induced apoptosis and inhibited tumor proliferation in vivo. Furthermore, low expression of AKR1B10 in colon cancer patients was correlated with decreased survival and poor prognosis. These results suggest that decreased expression of AKR1B10 could disrupt the tumor suppressive function of p53, which result in decreased survival in colorectal cancer patients. In summary, AKR1B10 may be a novel prognostic predictor and a novel therapeutic target for colorectal cancer.
Implications: AKR1B10, a transcriptional target of p53, is also a novel prognostic and therapeutic molecule in colorectal cancer. Mol Cancer Res; 11(12); 1554–63. ©2013 AACR.
Incidence and Predictors of End-Stage Renal Disease in Outpatients With Systolic Heart Failure
Authors: Bosselmann Helle , Gislason Gunnar , Gustafsson Finn , Hildebrandt Per R. , Videbaek Lars , Kober Lars , Torp-Pedersen Christian , Tonder Niels , Rossing Kasper , Christensen Stefan , Kamper Anne-Lise , Heaf James , Schou Morten 
Published: October 2013

Background—
Renal dysfunction is an important prognostic factor in heart failure (HF), but whether this dysfunction progresses to end-stage renal disease (ESRD) is unknown. Therefore, we examined incidence and predictors of ESRD in outpatients with HF.

Methods and Results—

Patients with systolic HF were identified in The Danish Heart Failure database and new-onset ESRD from the Danish Registry on Dialysis. Renal function was estimated by The Chronic Kidney Disease Epidemiology Collaboration equation and patients grouped by estimated glomerular filtration rate (eGFR)—group I: ≥60 mL/min per 1.73 m
2
, group II: 30 to 59 mL/min per 1.73 m
2
, group III: 15 to 29 mL/min per 1.73 m
2
, group IV: <15 mL/min per 1.73 m
2
. Cox hazard models for time to ESRD, to death, and the composite end point of ESRD or death were constructed and predictors of ESRD identified. A total of 8204 patients were included in the analyses. Median age was 70 years (Q, 61–77), 28% were women, median left ventricular ejection fraction was 30% (Q, 24–40), and median eGFR was 68 (Q, 51–85) mL/min per 1.73 m
2
. Forty-one patients developed ESRD (1.3/1000 patient-years). Baseline eGFR group II (
P
<0.001), eGFR group III (
P
<0.001), eGFR group IV (
P
<0.001), uncontrolled hypertension (
P
=0.049), need of diuretics, and age <60 years (
P
=0.016) were associated with time to ESRD.

Conclusions—

ESRD is rare in outpatients with systolic HF and is mainly observed in patients with an eGFR <30 mL/min per 1.73 m
2
. A low eGFR, age <60 years, need of diuretics, and uncontrolled hypertension identify patients with an increased risk for ESRD.
Age-Associated Defects in EphA2 Signaling Impair the Migration of Human Cardiac Progenitor Cells
Authors: Goichberg Polina , Kannappan Ramaswamy , Cimini Maria , Bai Yingnan , Sanada Fumihiro , Sorrentino Andrea , Signore Sergio , Kajstura Jan , Rota Marcello , Anversa Piero , Leri Annarosa 
Published: October 2013

RETRACTION
This article has been retracted:

Circulation
. 2019;139:e2–e2. DOI: 10.1161/CIR.0000000000000643
Domain-general Signals in the Cingulo-opercular Network for Visuospatial Attention and Episodic Memory
Authors: Sestieri Carlo , Corbetta Maurizio , Spadone Sara , Romani Gian Luca , Shulman Gordon L. 
Published: October 2013

Abstract
We investigated the functional properties of a previously described cingulo-opercular network (CON) putatively involved in cognitive control. Analyses of common fMRI task-evoked activity during perceptual and episodic memory search tasks that differently recruited the dorsal attention (DAN) and default mode network (DMN) established the generality of this network. Regions within the CON (anterior insula/frontal operculum and anterior cingulate/presupplementary cortex) displayed sustained signals during extended periods in which participants searched for behaviorally relevant information in a dynamically changing environment or from episodic memory in the absence of sensory stimulation. The CON was activated during all phases of both tasks, which involved trial initiation, target detection, decision, and response, indicating its consistent involvement in a broad range of cognitive processes. Functional connectivity analyses showed that the CON flexibly linked with the DAN or DMN regions during perceptual or memory search, respectively. Aside from the CON, only a limited number of regions, including the lateral pFC, showed evidence of domain-general sustained activity, although in some cases the common activations may have reflected the functional-anatomical variability of domain-specific regions rather than a true domain generality. These additional regions also showed task-dependent functional connectivity with the DMN and DAN, suggesting that this feature is not a specific marker of cognitive control. Finally, multivariate clustering analyses separated the CON from other frontoparietal regions previously associated with cognitive control, indicating a unique fingerprint. We conclude that the CON's functional properties and interactions with other brain regions support a broad role in cognition, consistent with its characterization as a task control network.
Post-Agreement Negotiations in the Comprehensive Nuclear-Test-Ban Treaty Regime
Authors: Melamud Mordechai (Moti) 
Published: October 2013

AbstractWhen considering the concept of post-agreement negotiations (PAN), the CTBT presents a particularly interesting case, because of its elusive status caused by the unusually long time lag between the treaty’s adoption in 1996 and its still unattained entry into force. For almost two decades, negotiations on key elements have been ongoing in the Preparatory Commission (PrepCom) in preparation for entry-into-force as required by the treaty. This article explores the challenges of PAN in the framework of the PrepCom and its place in the CTBT regime evolution. Using four factors in regime development – adjustment, maintenance, cybernetics and exogenous factors – the work of the PrepCom concerning verification is analyzed. Technical and political issues are described as examples from the PrepCom’s work since the opening of the CTBT for signature illustrating regime building through post agreement negotiations.
CTBT On-Site Inspection: A Special Case of Post-Agreement Negotiation
Authors: Melamud Mordechai (Moti) 
Published: October 2013

AbstractThis article examines negotiations expected to be conducted during actual implementation after entry-into-force of the Comprehensive Nuclear-Test-Ban Treaty (CTBT). It analyzes the negotiations to be undertaken with regards to on-site inspection (OSI) procedures, and their unique character as post-agreement negotiations (PAN) is identified. In particular, the OSI negotiations will be conducted at the Executive Council (EC) level and will analyze whether violations of the treaty have occurred. This discussion further explores another level of negotiation that will occur during the OSI, between the inspected state and the inspection team, concerning the technical details of implementation. Our analysis demonstrates how these inspection negotiations will likely have an impact, well beyond the OSI itself, on the PAN in the EC regarding OSI, and further on PAN in policymaking organs, and thus on regime evolution.
Multilevel Regimes and Asserting the “Right to Negotiate:” Fitting the Public into Post-Agreement Negotiation
Authors: Spector Bertram I. 
Published: October 2013

AbstractEmerging changes to post-agreement negotiation structures and actors can have important implications for the process and outcome of negotiated agreements. These innovations include the coexistence of negotiated global and regional regimes on the same policy issue, as well as civil society organizations that assert their “right to negotiate” at the domestic level to promote national compliance with regime standards and provisions. The evolution of these factors within the post-agreement negotiations of the United Nations Convention Against Corruption (UNCAC) is used as a case study. Globalization and communications technology trends play a major role in promoting these changes.
Is Reconciliation Negotiable?
Authors: Rosoux Valérie 
Published: October 2013

AbstractThe purpose of this article is to question some basic assumptions regarding reconciliation after wars and mass atrocities. Indeed, how can numerous policy-makers, practitioners, and scholars contend that reconciliation is necessary while it is often distrusted and rejected by victims? Are there not cases where calls for reconciliation would prove to be fruitless and even detrimental for peace and/or democracy? To answer these questions, it is worth looking at the interactions between reconciliation and negotiation. Beyond a theoretical interest, this question has a direct impact for practitioners; a better understanding of the issue is actually a sine qua non condition for more efficient interventions. In terms of methodology, this study refers to various examples as illustrative cases (Afghanistan, Rwanda, South-Africa, and the Franco-German case). Its objective is not to capture the complexity of each case study but to determine to what extent reconciliation can be considered as negotiable.
Politics of Cinema in Hashemite Iraq
Authors: Bishop Elizabeth 
Published: October 2013

Abstract
Hashemite Iraq was better integrated into the global cinema that other Arab countries. Baghdad audiences loved film noir, and the US succeeded in displacing the UK as a source of newsreels, as well. During the Cold War’s first decade, Hollywood continued to pump inexpensive productions and aged celluloid through Iraq, including films made under US government contracts. Local viewers responded thoughtfully to such films, engaging themes such as responsibility and guilt. Against this general background, specific allegations that testing of weapons delivery systems for germ warfare continued after the end of the Korean War, are assessed in the light that public health authorities reported a series of outbreaks of meningitis among audiences in Baghdad cinemas.
Lorsque le derviche tourneur était un mystique nomade : Sabûhî Ahmed Dede. Du marquage territorial et des personnalites marquantes
Authors: Ambrosio Alberto Fabio 
Published: October 2013

Abstract
Sabûhî Ahmed Dede (d. 1647) is one of the most emblematic and original characters of Ottoman Sufism from the 17th century. Effectively Sabûhî fits into the great tradition of the mevlevî, without however neglecting the other Sufi traditions present in Anatolia. In particular, his tendency to embrace bektaşî and above all kalenderî Sufism makes him an interesting personality which enables one to get to know better the characteristic of Sufism and especially of the Ottoman type to be affiliated to several confraternities of diverse mystical tendencies. Some of Sabûhî’s Ottoman verses, translated for the first time in French, illustrate this tendency to a slightly antinomic Sufism, open to different traditions. In the 17th century of the Ottomans and of Anatolia characterized by a debate which opposed on Sufism a greater loyalty to Islamic law, Sabûhî is representative of a long tradition of the nomad traveler open to discovering the Sufi universe in its entirety.