bluuebunny/crossref_metadata_2025_split huggingface dataset:
The gravitational-wave emission from the explosion of a 15 solar mass star with rotation and magnetic fields
Authors: Powell Jade , Müller Bernhard 
Published: July 2024

ABSTRACT
Gravitational waveform predictions from 3D simulations of explosions of non-rotating massive stars with no magnetic fields have been extensively studied. However, the impact of magnetic fields and rotation on the core-collapse supernova gravitational-wave signal is not well understood beyond the core-bounce phase. Therefore, we perform four magnetohydrodynamical simulations of the explosion of a $15\, {\rm M}_{\odot }$ star with the SFHx and SFHo equations of state. All of the models start with a weak magnetic field strength of $10^{8}$ G, and two of the models are rapidly rotating. We discuss the impact of the rotation and magnetic fields on the gravitational-wave signals. We find that the weak pre-collapse fields do not have a significant impact on the gravitational-wave signal amplitude. With rapid rotation, the f/g-mode trajectory can change in shape, and the dominant emission band becomes broader. We include the low-frequency memory component of the gravitational-wave signal from both matter motions and neutrino emission anisotropy. We show that including the gravitational waves from anisotropic neutrino emission increases the supernova gravitational-wave detection distances for the Einstein Telescope. The gravitational waves from anisotropic neutrino emission would also be detectable out to Mpc distances by a moon-based gravitational-wave detector.
Shell mergers in the late stages of massive star evolution: new insight from 3D hydrodynamic simulations
Authors: Rizzuti F , Hirschi R , Varma V , Arnett W D , Georgy C , Meakin C , Mocák M , Murphy A StJ , Rauscher T 
Published: July 2024

ABSTRACT
One-dimensional (1D) stellar evolution models are widely used across various astrophysical fields, however they are still dominated by important uncertainties that deeply affect their predictive power. Among those, the merging of independent convective regions is a poorly understood phenomenon predicted by some 1D models but whose occurrence and impact in real stars remain very uncertain. Being an intrinsically multi-D phenomenon, it is challenging to predict the exact behaviour of shell mergers with 1D models. In this work, we conduct a detailed investigation of a multiple shell merging event in a 20 M$_\odot$ star using 3D hydrodynamic simulations. Making use of the active tracers for composition and the nuclear network included in the 3D model, we study the merging not only from a dynamical standpoint but also considering its nucleosynthesis and energy generation. Our simulations confirm the occurrence of the merging also in 3D, but reveal significant differences from the 1D case. Specifically, we identify entrainment and the erosion of stable regions as the main mechanisms that drive the merging, we predict much faster convective velocities compared to the mixing-length theory velocities, and observe multiple burning phases within the same merged shell, with important effects for the chemical composition of the star, which presents a strongly asymmetric (dipolar) distribution. We expect that these differences will have important effects on the final structure of massive stars and thus their final collapse dynamics and possible supernova explosion, subsequently affecting the resulting nucleosynthesis and remnant.
Radial halo substructure in harmony with the Galactic bar
Authors: Dillamore Adam M , Belokurov Vasily , Evans N Wyn 
Published: July 2024

ABSTRACT
Overdensities in the radial phase space $(r,v_{\rm r})$ of the Milky Way’s halo have previously been associated with the phase-mixed debris of a highly radial merger event such as Gaia Sausage–Enceladus. We present and test an alternative theory in which the overdense ‘chevrons’ are instead composed of stars trapped in resonances with the Galactic bar. We develop an analytic model of resonant orbits in the isochrone potential, and complement this with a test particle simulation of a stellar halo in a realistic barred Milky Way potential. These models are used to predict the appearance of action space $(J_\phi ,J_{\rm r})$ and radial phase space in the Solar neighbourhood. They are able to reproduce almost all salient features of the observed chevrons. In particular, both the analytic model and simulation predict that the chevrons are more prominent at $v_{\rm r}\ \lt\ 0$ when viewed near the Sun, as is observed by Gaia. This is inconsistent with formation by an ancient merger event. We also associate individual chevrons with specific resonances. At a bar pattern speed of $\Omega _\mathrm{b}=35$ km s$^{-1}$ kpc$^{-1}$, the two most prominent prograde chevrons align very closely with the corotation and outer Lindblad resonances. The former can be viewed as a highly eccentric extension of the Hercules stream. Finally, our model predicts that the $v_{\rm r}$ asymmetry changes sign as a function of Galactic radius and azimuth, and we find evidence that this is indeed the case in the Milky Way.
The FLAMINGO simulation view of cluster progenitors observed in the epoch of reionization with JWST
Authors: Lim Seunghwan , Tacchella Sandro , Schaye Joop , Schaller Matthieu , Helton Jakob M , Kugel Roi , Maiolino Roberto 
Published: July 2024

ABSTRACT
Motivated by the recent JWST discovery of galaxy overdensities during the Epoch of Reionzation, we examine the physical properties of high-z protoclusters and their evolution using the Full-hydro Large-scale structure simulations with All-sky Mapping for the Interpretation of Next Generation Observations (FLAMINGO) simulation suite. We investigate the impact of the apertures used to define protoclusters, because the heterogeneous apertures used in the literature have limited our understanding of the population. Our results are insensitive to the uncertainties of the subgrid models at a given resolution, whereas further investigation into the dependence on numerical resolution is needed. When considering galaxies more massive than $M_\ast \, {\simeq }\, 10^8\, {\rm M_\odot }$, the FLAMINGO simulations predict a dominant contribution from progenitors similar to those of the Coma cluster to the cosmic star formation rate density during the reionization epoch. Our results indicate the onset of suppression of star formation in the protocluster environments as early as $z\, {\simeq }\, 5$. The galaxy number density profiles are similar to NFW (Navarro–Frenk–White profile) at $z\, {\lesssim }\, 1$ while showing a steeper slope at earlier times before the formation of the core. Different from most previous simulations, the predicted star formation history for individual protoclusters is in good agreement with observations. We demonstrate that, depending on the aperture, the integrated physical properties including the total (dark matter and baryonic) mass can be biased by a factor of 2 to 5 at $z\, {=}\, 5.5$–7, and by an order of magnitude at $z\, {\lesssim }\, 4$. This correction suffices to remove the ${\simeq }\, 3\, \sigma$ tensions with the number density of structures found in recent JWST observations.
Denoising diffusion delensing: reconstructing the non-Gaussian CMB lensing potential with diffusion models
Authors: Flöss Thomas , Coulton William R , Duivenvoorden Adriaan J , Villaescusa-Navarro Francisco , Wandelt Benjamin D 
Published: July 2024

ABSTRACT
Optimal extraction of cosmological information from observations of the cosmic microwave background (CMB) critically relies on our ability to accurately undo the distortions caused by weak gravitational lensing. In this work, we demonstrate the use of denoising diffusion models in performing Bayesian lensing reconstruction. We show that score-based generative models can produce accurate, uncorrelated samples from the CMB lensing convergence map posterior, given noisy CMB observations. To validate our approach, we compare the samples of our model to those obtained using established Hamiltonian Monte Carlo methods, which assume a Gaussian lensing potential. We then go beyond this assumption of Gaussianity, and train and validate our model on non-Gaussian lensing data, obtained by ray-tracing N-body simulations. We demonstrate that in this case, samples from our model have accurate non-Gaussian statistics beyond the power spectrum. The method provides an avenue towards more efficient and accurate lensing reconstruction, which does not rely on an approximate analytical description of the posterior probability. The reconstructed lensing maps can be used as an unbiased tracer of the matter distribution, and to improve delensing of the CMB, resulting in more precise cosmological parameter inference.
High-level tumour methylation of BRCA1 and RAD51C is required for homologous recombination deficiency in solid cancers
Authors: Xu Lijun , Liddell Brett , Nesic Ksenija , Geissler Franziska , Ashwood Lauren M , Wakefield Matthew J , Scott Clare L , Waddell Nicola , Kondrashova Olga 
Published: July 2024

Abstract
In ovarian and breast cancer, promoter methylation of BRCA1 or RAD51C is a promising biomarker for PARP inhibitor response, as high levels lead to homologous recombination deficiency (HRD). Yet the extent and role of such methylation in other cancers is not clear. This study comprehensively investigated promoter methylation of eight homologous recombination repair genes across 23 solid cancer types. Here, we showed that BRCA1 methylated cancers were associated with reduced gene expression, loss of heterozygosity (LOH), TP53 mutations and genomic features of HRD. We identified BRCA1 methylation in 3% of the copy-number high subtype of endometrial cancer, and as a rare event in six other cancer types, including lung squamous cell, pancreatic, bladder and stomach cancer. RAD51C promoter methylation was widespread across multiple cancer types, but HRD features were only observed for cases which contained high-level tumour methylation and LOH of RAD51C. While RAD51C methylation was frequent in stomach adenocarcinoma (6%) and low-grade glioma (2.5%), it was mostly detected at a low tumour level, suggestive of heterozygous methylation, and was associated with CpG island methylator phenotype. Our findings indicate that high-level tumour methylation of BRCA1 and RAD51C should be explored as a PARP inhibitor biomarker across multiple cancers.
Fertility preserving techniques in neuro-oncology patients: A systematic review
Authors: Osborne-Grinter Maia , Sanghera Jasleen Kaur , Bianca Offorbuike Chiamaka , Kaliaperumal Chandrasekaran 
Published: July 2024

Abstract

Background
Advancements in cancer treatments have enhanced survival rates and quality of life for patients with central nervous system (CNS) tumors. There is growing recognition of the significance of fertility preservation methods. Currently, techniques, including oocyte cryopreservation and sperm cryopreservation are established. Nevertheless, oncologists may exhibit reluctance when referring patients to reproductive specialists. This review aimed to assess the best evidence for fertility preservation techniques used in patients with CNS cancers and evaluate outcomes relating to their success and complications.

Methods
Two reviewers performed a search of Pubmed, Embase, Medline, Cochrane, and Google Scholar. Papers were included if they reported at least 1 fertility preservation technique in a neuro-oncology patient. Non-English studies, editorials, animal studies, and guidelines were excluded. Meta-analysis was performed using the random effects model.

Results
Sixteen studies containing data from 237 participants (78.8% female) were included in the systematic review and meta-analysis, of whom 110 (46.4%) underwent fertility preservation techniques. All patients (100%) successfully underwent fertility preservation with 1 participant (2.9%) returning to rewarm their oocytes, embryos or sperm. On average, 17.8 oocytes were retrieved with 78%, ultimately being cryopreserved. Five (6.0%) patients successfully conceived 9 healthy-term children after utilizing their cryopreserved sperm, embryos, or oocytes. Moreover, 6 patients successfully conceived naturally or using intrauterine insemination, resulting in 7 healthy-term children.

Conclusions
Fertility preservation techniques could offer a safe and effective way for neuro-oncology patients to deliver healthy-term babies following treatment. However, further studies concerning risks, long-term pregnancy outcomes, and cost-effectiveness are needed.
A Qualitative Investigation of Nicotine and Tobacco use in Young Pregnant and Birthing Sexual Minority People
Authors: De Genna Natacha M , Boss Nicole , Hossain Fahmida , Frankeberger Jessica , Mark Elyse , Coulter Robert W S 
Published: July 2024

Abstract

Introduction
Sexual minority (SM) youth, especially those who identify as bisexual, have higher rates of nicotine and tobacco use and are more likely to become pregnant at a younger age than heterosexual youth. The goal of this study was to investigate the nicotine and tobacco experiences and motivations of SM people before and during pregnancy.

Aims and Methods
Pregnant and birthing individuals ages 16–24 who identified as a SM in an online survey were recruited for semi-structured video interviews about nicotine and tobacco use. Thirteen participants described nicotine and tobacco initiation, current or recent use, and cessation efforts. Using thematic analysis, the research team coded de-identified interview transcripts and identified themes related to their nicotine and tobacco use.

Results
Participants were cisgender women (average age = 19.6). Most identified as bisexual (86%) in addition to Black (36%) or biracial (36%). Four themes about nicotine and tobacco use were identified from participant interviews. Participants’ reasons for nicotine and tobacco initiation were social, yet reasons for more regular use were stress-related. Participants’ use of cigarettes was triggered by their cannabis use, and several substituted cannabis for cigarettes during cessation attempts. Participants identified pregnancy as a strong motivator to quit smoking, and attempted cessation without clinical assistance.

Conclusions
Young SM people’s greater risk of initiation and dependence on nicotine and tobacco products prior to conception may be related to social needs, stress, and use of cannabis. Current approaches and materials on smoking cessation are not being utilized by this population.

Implications
This is the first qualitative study of nicotine and tobacco use among young pregnant SM people, primarily bisexual-identified, who are underrepresented in prenatal tobacco research. By telling their own stories, SM participants with lived experience of nicotine and tobacco use described the evolution of their motivations to use these products over time, cannabis use as a precipitant, the importance of pregnancy for smoking cessation, and perceptions about effective and ineffective factors in cessation efforts. The results of this study provide key information for prevention efforts to reduce tobacco-related health disparities for SM people.
Patient-reported outcome measures for paediatric gender-affirming care: A systematic review
Authors: Jackman Liam , Chan Cynthia , Jacklin Chloë , Deck Eve , Lee Ann C , Stepney Melissa , Harrison Conrad , Jain Abhilash , Rodrigues Jeremy , Kamran Rakhshan 
Published: July 2024

Abstract

Objectives
Patient needs must be comprehensively measured to offer paediatric gender-affirming care in line with clinical standards. Patient-reported outcome measures (PROMs) are self-report tools that measure outcomes deemed to be of importance to patients. PROMs may assess a single outcome or multiple outcomes simultaneously, such as symptoms, functional ability, and quality of life. This study aims to identify PROMs for paediatric gender-affirming care.

Methods
This systematic review is PRISMA-compliant and was prospectively registered on PROSPERO (CRD42023461959). Six databases were searched: PubMed, Embase, MEDLINE, PsycINFO, CINAHL, and Web of Science from inception to December 16, 2022. Articles meeting the following criteria were included: 1) Original article; 2) Administers a formally-developed PROM; 3) Focuses on gender-affirming care; and 4) Focuses on paediatric populations. Screening and data extraction occurred independently and in duplicate. Data extracted include study/demographic information, and details of PROM used.

Results
In total, 20 articles were included, representing a total of 5793 paediatric patients undergoing gender-affirming care. Most studies (13, 65%) focused on hormonal gender-affirming care. A total of 38 different PROMs for paediatric gender-affirming care were identified, ranging from 4 to 120 items each (mean 23 items; median 14 items). Most PROMs (n = 22) measured psychological functioning, with eight PROMs measuring quality of life, and three PROMs measuring gender-related concepts (i.e., gender dysphoria/euphoria). Commonly used PROMs include the Utrecht Gender Dysphoria Scale (n = 4; 20%), Body Image Scale (n = 5;25%), and Youth Self-Report (n = 8; 40%).

Conclusions
A total of 38 PROMs were identified measuring a range of concepts for paediatric gender-affirming care.
Employer Dominance and Worker Earnings in Finance
Authors: Ma Wenting 
Published: July 2024

Abstract
A few large firms in the U.S. financial system achieve substantial economic gains. Their dominance sets them apart while also raising concerns about the suppression of worker earnings. Utilizing administrative data, this study reveals that the largest financial firms pay workers an average of 30.2% more than their smallest counterparts, significantly exceeding the 7.9% disparity in nonfinance sectors. This positive size-earnings relationship is consistently more pronounced in finance, even during the 2008 crisis or compared to the high-tech sector. Evidence suggests that large financial firms’ excessive gains, coupled with their workers’ sought-after skills, explain this distinct relationship. (JEL G20, J31, J42, L11, L12, L13)
The evolution and ongoing challenge of unproven cell-based interventions
Authors: Brinsfield Taylor N , Pinson Noah R , Levine Aaron D 
Published: July 2024

Abstract
Unproven cell-based interventions (CBIs) emerged early in the 2000s as a particularly problematic form of unproven therapy and remain a vexing policy problem to this day. These unproven interventions can harm patients both physically and financially and can complicate the process of developing a rigorous evidence base to support the translation of novel stem cell or other cell therapies. In this concise review, we examine the emergence of unproven CBIs and the various policy approaches that have been pursued or proposed to address this problem. We review the evolution of this field over the last 2 decades and explore why these policy efforts have proven challenging. We conclude by highlighting potential directions that the field could evolve and urging continued attention to both current and future forms of unproven CBIs to minimize future risks to patients and the field and to promote the development of evidence-based cell therapies.
11Plastic Theory/Studies
Authors: Martell James 
Published: July 2024

Abstract
While this year’s chapter on plastic theory/studies is relatively short, with only three texts reviewed, it is a harbinger of important texts in preparation that, next year, will broaden the field into dimensions as diverse as world literature and theology. Such an expansion is logical when we see that the texts published this year include: an important and practical textbook introduction as part of MIT Press’s Essential Knowledge series (Imari Walker-Franklin and Jenna Jambeck’s Plastics); a chapter in a book on flashpoint epistemologies (Ranjan Ghosh’s ‘Plastic Pedagogy: Rabindranath Tagore Revisited’); and a book that links plasticity to political thought (Fathali M. Moghaddam’s Political Plasticity). As this review will show, together these texts speak not only of the contemporary anxieties of a world enmeshed in climate and political catastrophes, but also of the pedagogical and political hopes of new generations of scholars and artists, who are thinking about plasticity and plastic theory—not only in texts but also in their practices and art—in relation to a future still in formation.
The advantages of inhouse testing to manage vaginitis treatment
Authors: Wilson Mariafrancesca Zampogna 
Published: July 2024

ABSTRACT
Vaginal discharge is a common presenting complaint in ambulatory care medicine, emergency medicine, primary care, and gynecology, accounting for nearly 10 million office visits annually in the United States. This article discusses management of abnormal vaginal discharge among women of childbearing age and the clinical significance of inhouse diagnostic tools. Provider-performed microscopy is an invaluable clinical skill that allows for immediate diagnosis, treatment, and management of infections and coinfections and should be strongly considered when evaluating a patient.
Perceptions of telehealth use by PAs post-COVID-19
Authors: Raspet Erin , Gietzen Lindsay 
Published: July 2024

ABSTRACT

Objective:
Use of telemedicine and remote patient monitoring can provide significant cost savings through improved disease control and reduced exacerbations. This study investigated physician associates'/assistants' (PAs') perceptions of telemedicine to inform future use and expansion of these programs.

Methods:
The Telehealth Usability Questionnaire was completed by 30 PAs recruited via social media. Data were coded and analyzed through an electronic spreadsheet program.

Results:
PAs generally felt that telemedicine was a helpful tool to increase access to care (M = 4.129) but did not replace in-person visits. Variation in responses related specifically to the platform indicated PAs' varying experiences about ease of use.

Conclusions:
Findings demonstrated that PAs from a variety of practice settings found telemedicine to be a helpful tool to reduce barriers and improve access to care. However, PAs did not feel that telemedicine replaces in-person visits.