bluuebunny/crossref_metadata_2025_split huggingface dataset:
The impact of antiplatelet and anticoagulant medications on early implant failure following sinus floor augmentation: A retrospective cohort analysis
Authors: Jonas Ehud , Masri Daya , Avishai Gal , Masri‐Iraqi Hiba , Chaushu Gavriel , Chaushu Liat 
Published: August 2024

AbstractIntroductionThe effect of antiplatelet and anticoagulant medications on the outcomes of sinus floor augmentation remains unclear.MethodsThis retrospective cohort study analyzed data from electronic medical records of consecutive patients undergoing sinus floor augmentation at a single medical center. Patients were categorized into three categories: patients under antiplatelet medications, patients under anticoagulation medications, and healthy individuals. Data collected included tobacco smoking, residual alveolar bone height, timing of implant placement, materials used, vertical bone gain, early implant failure (EIF), and complications such as Schneiderian membrane perforation and postoperative bleeding. Multivariable analysis was performed to assess risk factors for EIF. Statistical significance was considered below 5%.ResultsAmong 110 patients with 305 implants, EIF occurred in 10% of patients and 4.65% of implants. No significant difference in postoperative bleeding or EIF was found between study groups. Univariate and multivariable analyses highlighted tobacco smoking (odds ratio [OR] = 7.92), lower residual alveolar ridge height (OR = 0.81), and staged implant placement (OR = 4.64) as significant EIF risk factors in this cohort.ConclusionsAnticoagulant and antiplatelet therapies do not significantly elevate the risk of EIF or postoperative bleeding following sinus floor augmentation. Tobacco smoking, residual alveolar ridge height and staged sinus floor augmentation were risk factors for EIF in patients using antiplatelet or anticoagulation medications undergoing sinus floor augmentation.
A Nomogram for Predicting Cancer‐Specific Survival in Young Patients With Advanced Lung Cancer Based on Competing Risk Model
Authors: Li Jiaxin , Pan Bolin , Huang Qiying , Zhan Chulan , Lin Tong , Qiu Yangzhi , Zhang Honglang , Xie Xiaohong , Lin Xinqin , Liu Ming , Wang Liqiang , Zhou Chengzhi 
Published: August 2024

ABSTRACTBackgroundYoung lung cancer is a rare subgroup accounting for 5% of lung cancer. The aim of this study was to compare the causes of death (COD) among lung cancer patients of different age groups and construct a nomogram to predict cancer‐specific survival (CSS) in young patients with advanced stage.MethodsLung cancer patients diagnosed between 2004 and 2015 were extracted from the Surveillance, Epidemiology, and End Results (SEER) database and stratified into the young (18–45 years) and old (> 45 years) groups to compare their COD. Young patients diagnosed with advanced stage (IVa and IVb) from 2010 to 2015 were reselected and divided into training and validation cohorts (7:3). Independent prognostic factors were identified through the Fine‐Gray's test and further integrated to the competing risk model. The area under the receiver operating characteristic curve (AUC), consistency index (C‐index), and calibration curve were applied for validation.ResultsThe proportion of cancer‐specific death (CSD) in young patients was higher than that in old patients with early‐stage lung cancer (p < 0.001), while there was no difference in the advanced stage (p = 0.999). Through univariate and multivariate analysis, 10 variables were identified as independent prognostic factors for CSS. The AUC of the 1‐, 3‐, and 5‐year prediction of CSS was 0.688, 0.706, and 0.791 in the training cohort and 0.747, 0.752, and 0.719 in the validation cohort. The calibration curves demonstrated great accuracy. The C‐index of the competing risk model was 0.692 (95% CI: 0.636–0.747) in the young patient cohort.ConclusionYoung lung cancer is a distinct entity with a different spectrum of competing risk events. The construction of our nomogram can provide new insights into the management of young patients with lung cancer.
Event‐related potentials of familiar monosyllabic words with unexpected lexical tones: A picture‐word study of Mandarin‐speaking preschoolers with and without a history of late talking
Authors: Lu Hsin‐Hui , Liu Hong‐Hsiang , Tsao Feng‐Ming 
Published: August 2024

AbstractThis study examined how Mandarin‐speaking preschoolers with and without a history of late talking (LT) process familiar monosyllabic words with unexpected lexical tones, focusing on both phonological and semantic violations. This study initially enrolled 64 Mandarin‐speaking toddlers: 31 with a history of LT (mean age: 27.67 months) and 33 without a history of LT (non‐LT) (mean age: 27.85 months). Event‐related potentials were recorded at the age of 4 years during a picture‐word mismatch task (LT mean age: 51.36 months; non‐LT mean age: 51.20 months); in this task, the participants were presented with auditory words either matching (Tone 3) or mismatching with images in terms of their lexical tones; the mismatches encompassed acoustically dissimilar (Tone 1) and similar (Tone 2) mismatches. A significant difference in the phonological mapping negativity (PMN) responses to Tones 1 and 3 was observed only in the non‐LT group. However, differences in the N400 responses to Tones 1 and 3 remained consistent across both groups. In addition, greater differences in the PMN responses between Tones 1 and 3 were associated with higher language proficiency during the preschool period. The PMN response serves as an indicator of neural correlates in lexical tone processing, reflecting challenges encountered by preschoolers with a history of LT when processing the lexical tones of familiar words. Furthermore, the PMN response was correlated with concurrent language abilities. These findings indicate the importance of early tonal perception development for Mandarin speakers with a history of LT.Research Highlights
Preschoolers with a history of late talking (LT), similar to preschoolers without such a history, can establish word expectations and detect the lexical tone violation in real time. However, those with a history of LT require additional time to process acoustic cues and differentiate between word semantics based on lexical tone information.
The phonological mapping negativity response serves as an indicator of neural correlates in lexical tone processing, reflecting challenges encountered by preschoolers with a history of LT when processing the lexical tones of familiar words.
The present findings indicate the importance of early intervention for Mandarin speakers with a history of LT, with an emphasis on lexical tone processing from toddlerhood.
Associations between sex, systemic iron and inflammatory status and subcortical brain iron
Authors: Spence Holly , Mengoa‐Fleming Stephanie , Sneddon Alan A. , McNeil Christopher J. , Waiter Gordon D. 
Published: August 2024

AbstractBrain iron increases in several neurodegenerative diseases are associated with disease progression. However, the causes of increased brain iron remain unclear. This study investigates relationships between subcortical iron, systemic iron and inflammatory status. Brain magnetic resonance imaging (MRI) scans and blood plasma samples were collected from cognitively healthy females (n = 176, mean age = 61.4 ± 4.5 years, age range = 28–72 years) and males (n = 152, mean age = 62.0 ± 5.1 years, age range = 32–74 years). Regional brain iron was quantified using quantitative susceptibility mapping. To assess systemic iron, haematocrit, ferritin and soluble transferrin receptor were measured, and total body iron index was calculated. To assess systemic inflammation, C‐reactive protein (CRP), neutrophil:lymphocyte ratio (NLR), macrophage colony‐stimulating factor 1 (MCSF), interleukin 6 (IL6) and interleukin 1β (IL1β) were measured. We demonstrated that iron levels in the right hippocampus were higher in males compared with females, while iron in the right caudate was higher in females compared with males. There were no significant associations observed between subcortical iron levels and blood markers of iron and inflammatory status indicating that such blood measures are not markers of brain iron. These results suggest that brain iron may be regulated independently of blood iron and so directly targeting global iron change in the treatment of neurodegenerative disease may have differential impacts on blood and brain iron.
Florida red scale, Chrysomphalus aonidum (Linnaeus, 1758) (Hemiptera: Diaspididae) in Morocco, infesting citrus orchards and an avocado tree
Authors: Smaili M. C. , Mrabti I. , Grijja H. , Watson G. W. , Moghaddam M. , Ziri R. 
Published: August 2024

AbstractA study was conducted on citrus and avocado trees in north‐western Morocco between February 2023 and April 2024 to detect scale insects (Hemiptera: Coccomorpha) and their associated natural enemies. A total of 55 orchards in seven provinces were studied. The Florida red scale, Chrysomphalus aonidum (Linnaeus, 1758) (Diaspididae) was found on leaves at two sites: a moderate infestation in one citrus orchard and one specimen on an avocado tree. This work is the first record of the scale insect on avocado in Morocco, and the first morphological description of C. aonidum from the country, based on 100 adult females mounted on microscope slides. Chrysomphalus aonidum is not causing economic damage in citrus or avocado orchards in Morocco. Two ectoparasitoid wasps (Aphytis melinus DeBach and Aphytis sp.; Hymenoptera: Aphelinidae), and three predatory beetles (Rhyzobius lophanthae Blaisdell, Chilocorus bipustulatus Linnaeus, and Clitostethus arcuatus Rosso; Coleoptera: Coccinellidae), were found associated with C. aonidum on citrus leaves.
Methylsulfonylmethane induces caspase‐dependent apoptosis in acute myeloid leukemia cell lines
Authors: Hekmatshoar Yalda , Karabay Arzu Zeynep , Ozkan Tulin , Koc Asli , Sunguroglu Asuman 
Published: August 2024

AbstractBackground: Acute myeloid leukemia (AML) is a heterogeneous ailment in both biological and clinical concepts. Numerous efforts have been devoted to discover natural compounds for combating cancer, which showed great potential in cancer management. Methylsulfonylmethane (MSM), an organosulfur dietary supplement, is utilized for improving various clinical conditions, particularly osteoarthritis. MSM can exert antitumor activity in a wide range of cancers. Objectives: The molecular mechanisms of action underlying antileukemic activity of MSM remain unclear. In this regard, we aimed to investigate the anticancer properties of MSM on human AML cell lines (U937 and HL60) with focus on underlying cell death mechanism. Methods: Anticancer activity of the MSM was examined employing MTT assay, Annexin V‐PE/7AAD staining, caspase3/7 activity test, and real‐time qPCR. Both cell lines were treated with different concentrations (50–400 mM) of MSM for 24 h. Pretreatment of the cells with a caspase inhibitor (i.e., Z‐VAD‐fmk) was performed for the assessment of apoptosis induction. Results: The results of MTT assay revealed that in both cell lines, the MSM markedly reduced cell viability in comparison to the control cells. Additionally, findings of Annexin V‐7AAD staining revealed that MSM induced apoptosis and activated caspase 3/7 in both cell lines markedly. Real‐time quantitative PCR results also supported the induction of apoptosis in AML cells. MSM altered the expression levels of various apoptotic genes (BAX, BAD, and BIM). Conclusion: Overall, our results indicated that MSM could induce apoptosis in AML cell lines in a dose‐dependent manner, which therefore could be utilized as an antileukemic agent.
European union funding of interest groups: Reassessing the balancing function and the promotion of good organizational practices
Authors: Salgado Rosa Sanchez , Hanegraaff Marcel , Crepaz Michele 
Published: August 2024

AbstractThe question of the legitimacy of government funding of interest groups as a democratic practice has been extensively discussed by scholars. On the one hand, research suggests that well‐resourced interest groups are better equipped to capture European Union (EU) funds, raising some questions regarding the elitist character of the EU system of interest representation. On the other hand, EU funds have been found to address imbalances in the system of interest representation by directing funding streams toward underrepresented citizen groups. The present study contributes to this open discussion, by 1) analyzing to which extent findings from previous studies can be replicated with a more nuanced research design and by employing the largest existing dataset on interest groups and EU funding, and by 2) testing new hypotheses inspired by an alternative theoretical focus to mainstream approaches: associative democracy. To do so, we use data from the Comparative Interest Group Survey, a dataset of almost 2500 organizations across eight EU countries (Belgium, the Netherlands, Sweden, Portugal, Slovenia, Lithuania, the Czech Republic and Poland) and at the EU level. Our results offer two main contributions. By replicating recent studies, our findings nuance conclusions drawn this far regarding existing biases in the EU system of interest representation: it is true that rich and experienced interest groups are more likely to obtain EU funding. However, EU funding is also more likely to be allocated to NGOs, especially when they operate in business‐dominated policy areas. Moreover, we find that EU funds are not as concentrated in EU‐15 member states as previously thought. Finally, inspired by associative democracy, we show that EU funding is more often allocated where good practices are in place. These include membership representation as core function and membership influence over internal decision‐making processes.
The effectiveness of self‐regulated learning strategies in higher education blended learning: A five years systematic review
Authors: Luo Ren‐Zhi , Zhou Yue‐Liang 
Published: August 2024

AbstractBackgroundThe COVID‐19 has accelerated the transition to blended learning (BL) in higher education, prompting a need for further investigation into the efficacy of self‐regulated learning strategies (SRLS) in these new educational environments.ObjectiveThe primary goal of this research is to assess the effectiveness of SRLS in BL in higher education over the past five years, with a focus on trends, theoretical underpinnings, methodologies, and their impact on learning outcomes.MethodsThis paper used the PRISMA 2020 review process for multiple rounds of screening, encompassing identification, screening, eligibility determination, and final inclusion. Following rigorous screening procedures, a total of 15 SSCI articles were ultimately chosen for analysis. The study design incorporated a comprehensive six‐part coding scheme, with the selected articles focusing on SRLS in BL environments within higher education.Results and ConclusionsFrom 2019 to 2023, research on SRLS in BL environments in higher education has primarily focused on resource management, motivational beliefs, and metacognitive strategies, with a relatively limited emphasis on cognitive strategies. These studies have utilized a diverse range of theoretical frameworks, predominantly employing quantitative and mixed methods. Out of the 15 articles reviewed, 14 clearly indicate that SRLS have a positive impact on learning outcomes. Furthermore, this paper underscores the importance of interdisciplinary research and emphasizes the crucial role played by educators in supporting the implementation of SRLS. Future studies should delve deeper into exploring the effects of individual differences and environmental factors on SRLS.
Recurrence risk prediction models for hepatocellular carcinoma after liver transplantation
Authors: Zhang Xu , Chen Chi , Wang Yan , Xu Jun 
Published: August 2024

AbstractLiver transplantation (LT) is an effective method for curing hepatocellular carcinoma (HCC). However postoperative tumor recurrence can lead to higher mortality rates. To select suitable candidates for LT, the Milan Criteria (MC) were first proposed based on tumor morphological characteristics. For those patients who meet the MC, the MC can effectively reduce the postoperative tumor recurrence rate and improve the prognosis of patients undergoing LT. It has always been internationally recognized as the gold standard for selecting candidates for LT, marking a milestone in the history of LT for HCC. However, its strict conditions exclude some HCC patients who could benefit from LT. Therefore, comprehension consideration criteria, including serum biomarkers, tumor histology, and other factor, have been continuously proposed in addition to tumor morphology. This article summaries the prediction model for HCC recurrence after LT from five aspects: tumor morphology, serum markers, histopathology, cellular inflammatory factors and downstaging treatment before transplantation. The aim is to assist clinicians in accurately assessing HCC status, selecting appropriate liver transplant candidates, maximize graft and patients' survival, and optimizing the utilization of social health resources.
Laboratory‐based measures of executive function and daily living skills in young children with Down syndrome: informing future interventions
Authors: Van Deusen K. , Prince M. A. , Walsh M. M. , Esbensen A. J. , Patel L. R. , Pinks M. E. , Thurman A. J. , Abbeduto L. , Daunhauer L. A. , Fidler D. J. 
Published: August 2024

AbstractBackgroundAdaptive behaviour refers to the practical skills necessary for independence and is considered a high‐priority intervention target for children with neurogenetic conditions associated with intellectual disability, like Down syndrome (DS). Daily living skills (DLS) are a critical aspect of adaptive behaviour, but they have received little intervention attention, possibly because they involve a wide variety of skills across many settings. The present study aimed to advance DLS intervention science by examining the concurrent and longitudinal association between DLS performances and a cognitive skillset hypothesised to support DLS skill acquisition, executive function (EF).MethodsParticipants were 71 children with DS between the ages of 2.5 and 8.7 years (M = 5.23 years; standard deviation = 1.65) who completed a battery of adapted EF tasks and a primary caregiver who completed the Vineland Adaptive Behavior Scales 3rd Edition Parent/Caregiver Comprehensive Report Form. A subset of caregivers also provided 6‐ and 12‐month follow‐up adaptive behaviour information.ResultsResults demonstrated a positive association between EF task performance and DLS standard scores and v‐scores both concurrently and longitudinally.ConclusionsThe findings have implications for potential future intervention approaches that aim to strengthen DLS performances by advancing EF skills in this population.
Long non‐coding RNA TMEM147 antisense RNA 1/microRNA‐124/signal transducer and activator of transcription 3 axis in estrogen receptor‐positive breast cancer
Authors: Liang Wei , Zhang Xuanchang , Zhang Jia , Xia Haiyan , Wei Xiaowei 
Published: August 2024

AbstractObjectiveThis research aimed to probe the expression of long noncoding RNA TMEM147 antisense RNA 1 (TMEM147‐AS1)/micro‐RNA (miR)‐124/signal transducer and activator of transcription 3 (STAT3) axis in estrogen receptor (ER)‐positive breast cancer (BC).MethodsSixty ER‐positive BC patients undergoing surgical treatment were gathered. TMEM147‐AS1, miR‐124, and STAT3 expression levels in BC cells and tissues were measured. The binding sites of TMEM147‐AS1 and miR‐124, miR‐124, and STAT3 were analyzed and validated. The miR‐124, STAT3 overexpression (oe) sequences, TMEM147‐AS1 oe, and interference sequences and their control sequences were planned and cells were transfected to assess their functions in BC cells biological functions.ResultsTMEM147‐AS1, as well as STAT3 was extremely expressed and miR‐124 was lowly expressed in BC cells and tissues. Interference with TMEM147‐AS1 restrained ER‐positive BC cell malignant activities. Mechanistically, TMEM147‐AS1 could competitively bind miR‐124 in refraining miR‐124 expression, and STAT3 was a target gene of miR‐124. Oe of miR‐124 effectively reversed the enhancement of BC cell proliferation and invasion induced by TMEM147‐AS1 upregulation. Oe of STAT3 could reverse the inhibitory effect of miR‐124 on BC cell malignant behaviors.ConclusionTMEM147‐AS1 has oncogenic activity in ER‐positive BC, which may be a result of the altered miR‐124/STAT3 axis. Therefore, targeting the TMEM147‐AS1/miR‐124/STAT3 axis may be a target for ER‐positive BC therapy.
School District Leader Perspectives on Surveying Middle School Youth About Sexual Violence
Authors: Adhia Avanti , Lucas Ruby , Richey Ann E. , Rogers Megan , Van Wagner Nikki , Dils Laurie , Rivara Frederick P. , Bekemeier Betty 
Published: August 2024

ABSTRACTBACKGROUNDSchools are important contexts for preventing sexual violence (SV) among adolescents. Evaluating whether programming is effective requires surveying youth about SV experiences. However, school communities often have concerns about asking students, particularly those in middle school, about these experiences. This study sought to understand the types of concerns that school district leaders have related to surveying middle school students about SV and to identify ways to mitigate these concerns.METHODSWe conducted semi‐structured interviews with superintendents and school board members (n = 19) across Washington State and used inductive thematic analysis.RESULTSConcerns regarding surveying students about SV centered around 3 main themes: community norms and misconceptions, parental/caregiver discomfort, and survey language and administration. Concerns were particularly salient for sixth‐grade students. Suggestions for mitigating concerns included: providing clear motivation and reframing messaging to community members, involving parents and students in the survey process, and modifying survey language and administration.CONCLUSIONSResearchers administering surveys to middle school students on sensitive topics including SV may face pushback and must consider flexible approaches to allow research and evaluation to be conducted.
Pharmacokinetics and Alterations in Glucose and Insulin Levels After a Single Dose of Canagliflozin in Healthy Icelandic Horses
Authors: Michanek Peter , Bröjer Johan , Lilliehöök Inger , Fjordbakk Cathrine T. , Löwgren Minerva , Hedeland Mikael , Bergquist Jonas , Ekstrand Carl 
Published: August 2024

ABSTRACTCanagliflozin (CFZ) is a sodium‐glucose cotransporter‐2 inhibitor that has shown promising results as a drug for the treatment of insulin dysregulation in horses. Even though CFZ is used clinically, no pharmacokinetic data has previously been published. In this study, the pharmacokinetics of CFZ after administration of a single oral dose of 1.8 mg/kg in eight healthy Icelandic horses was examined. Additionally, the effect of treatment on glucose and insulin levels in response to a graded glucose infusion was investigated. Plasma samples for CFZ quantification were taken at 0, 0.33, 0.66, 1, 1.33, 1.66, 2, 2.33, 2.66, 3, 3.5, 4, 5, 6, 8, 12, 24, 32, and 48 h post administration. CFZ was quantified using UHPLC coupled to tandem quadrupole mass spectrometry (UHPLC‐MS/MS). A non‐compartmental analysis revealed key pharmacokinetic parameters, including a median Tmax of 7 h, a Cmax of 2350 ng/mL, and a t1/2Z of 28.5 h. CFZ treatment reduced glucose (AUCGLU, p = 0.001) and insulin (AUCINS, p = 0.04) response to a graded glucose infusion administered 5 h after treatment. This indicates a rapid onset of action following a single dose in healthy Icelandic horses. No obvious adverse effects related to the treatment were observed.