bluuebunny/crossref_metadata_2025_split huggingface dataset:
Safety and efficacy of the MitraClip® system for severe mitral regurgitation
Authors: Vakil Kairav , Roukoz Henri , Sarraf Mohammad , Krishnan Balaji , Reisman Mark , Levy Wayne C. , Adabag Selcuk 
Published: December 2013

BackgroundThe MitraClip® system is a newer percutaneous device that has shown promising results but data on its safety and efficacy in low‐ and high‐surgical risk populations continues to evolve. We performed a systematic review of the published studies reporting the safety and efficacy of MitraClip® implantation for treatment of moderate to severe and severe mitral regurgitation (MR).MethodsReviewers independently searched for relevant articles in Medline and abstracted clinical information based on pre‐defined criteria and end‐points. Patients were classified as low‐ or high‐surgical risk for conventional mitral valve (MV) surgery based on Society of Thoracic Surgeons score, EuroSCORE, or surgeon discretion. Primary safety outcome was 30‐day mortality and primary efficacy outcomes were freedom from death, ≥3+ MR, and requirement for MV surgery during follow‐up.ResultsImmediate and long‐term outcomes of 16 studies, including 2980 patients (age 73.7 ± 0.6 years; 63.3% males) receiving the MitraClip®, were analyzed. Acute procedural success rate was 91.4% with a procedural mortality of 0.1%. Mortality at 30 days and long‐term (310 days) follow‐up was 4.2 and 15.8%, respectively and was significantly higher in the high‐risk group (P = 0.003 and 0.019, respectively). Incidence of major procedural adverse outcomes was relatively low with blood transfusion accounting for most events. At follow‐up, the number of patients with ≥3+ MR reduced from 96.3% to 14.7% (P < 0.001), and those with NYHA class III/IV reduced from 83.2% to 23.4% (P < 0.001).ConclusionMitraClip® implantation for moderate to severe or severe MR appears to be safe with a very low procedural mortality. There is significant improvement in functional outcomes although long‐term mortality is high, especially in high surgical risk patients. © 2013 Wiley Periodicals, Inc.
Reduced Graphene Oxide Functionalized with a Luminescent Rare‐Earth Complex for the Tracking and Photothermal Killing of Drug‐Resistant Bacteria
Authors: Yang Xinjian , Li Zhenhua , Ju Enguo , Ren Jinsong , Qu Xiaogang 
Published: December 2013

AbstractAn antibacterial platform based on multifunctional reduced graphene oxide (rGO) that is responsive to near‐infrared (NIR) light has been constructed. By introducing a luminescent Eu3+ complex and vancomycin for bacteria tracking into one system, this platform could specifically recognize and light up bacteria. Antibacterial activity of this nanoscale construction under NIR illumination was investigated. Upon illumination with NIR light, this nanoscale architecture generates great heat locally, resulting in the death of drug‐resistant bacteria. These results indicate that the ability of this nanoscale platform to kill drug‐resistant bacteria has great potential for clinical pathogenic bacteria diagnosis and treatment.
Survivorship care plans: Is there buy‐in from community oncology providers?
Authors: Salz Talya , McCabe Mary S. , Onstad Erin E. , Baxi Shrujal S. , Deming Richard L. , Franco Regina A. , Glenn Lyn A. , Harper Gregory R. , Jumonville Alcee J. , Payne Roxanne M. , Peters Elissa A. , Salner Andrew L. , Schallenkamp John M. , Williams Sheron R. , Yiee Kevin , Oeffinger Kevin C. 
Published: December 2013

BACKGROUNDThe Institute of Medicine recommended that survivors of cancer and their primary care providers receive survivorship care plans (SCPs) to summarize cancer treatment and plan ongoing care. However, the use of SCPs remains limited.METHODSOncology providers at 14 National Cancer Institute Community Cancer Centers Program hospitals completed a survey regarding their perceptions of SCPs, including barriers to implementation, strategies for implementation, the role of oncology providers, and the importance of topics in SCPs (diagnosis, treatment, recommended ongoing care, and the aspects of ongoing care that the oncology practice will provide).RESULTSAmong 245 providers (response rate of 70%), 52% reported ever providing any component of an SCP to patients. The most widely reported barriers were lack of personnel and time to create SCPs (69% and 64% of respondents, respectively). The most widely endorsed strategy among those using SCPs was the use of a template with prespecified fields; 94% of those who used templates found them helpful. For each topic of an SCP, although 87% to 89% of oncology providers believed it was very important for primary care providers to receive the information, only 58% to 65% of respondents believed it was very important for patients to receive the information. Furthermore, 33% to 38% of respondents reported mixed feelings regarding whether it was the responsibility of oncology providers to provide SCPs.CONCLUSIONSPractices need additional resources to overcome barriers to implementing SCPs. We found resistance toward SCPs, particularly the perceived value for the survivor and the idea that oncology providers are responsible for SCP dissemination. Cancer 2014;120:722–30. © 2013 American Cancer Society.
Effect of a randomized controlled trial on the surgical treatment of spinal metastasis, 2000 through 2010: A population‐based cohort study
Authors: Kelly Michael L. , Kshettry Varun R. , Rosenbaum Benjamin P. , Seicean Andreea , Weil Robert J. 
Published: December 2013

BACKGROUNDThe effect of randomized controlled trials (RCT) on clinical practice patterns and patient outcomes is understudied. A 2005 RCT by Patchell et al demonstrated benefit for surgical decompression in patients with spinal metastasis (SpM). We examined trends in spinal surgery for patients with SpM before and after publication of the Patchell RCT.METHODSThe Nationwide Inpatient Sample (NIS) was used to identify a 20% stratified sample of surgical SpM admissions to nonfederal United States hospitals from 2000 to 2004 and 2006 to 2010, excluding 2005 when the RCT was published. Propensity scores were generated and logistic regression analysis was performed to compare outcomes in pre‐ and post‐RCT time periods.RESULTSA total of 7404 surgical admissions were identified. The rate of spine surgery increased post‐RCT from an average of 3.8% to 4.9% surgeries per metastatic admission per year (P = .03). Admissions in the post‐RCT group were more likely to be non‐Caucasian, lower income, Medicaid recipients, and have more medical comorbidities and a greater metastatic burden (P < .001). Logistic regression of the propensity‐matched sample showed increased odds post‐RCT for expensive hospital stay (2.9; 95% confidence interval [CI] = 2.6‐3.4) and some complications, including neurologic (1.7; 95% CI = 1.1‐2.8), venous thromboembolism (2.8; 95% CI = 1.9‐4.2), and decubitis ulcers (15.4; 95% CI = 6.7‐34.5). However, odds for in‐hospital mortality decreased (0.6; 95% CI = 0.5‐0.8).CONCLUSIONSSurgery for SpM increased after publication of a positive RCT. A significantly greater proportion of patients with lower socioeconomic status, more comorbidities, and greater metastatic burden underwent surgery post‐RCT. These patients experienced more postoperative complications and higher in‐hospital charges but less in‐hospital mortality. Cancer 2014;120:901–908. © 2013 American Cancer Society.
Impact of postremission consolidation chemotherapy on outcome after reduced‐intensity conditioning allogeneic stem cell transplantation for patients with acute myeloid leukemia in first complete remission: A report from the Acute Leukemia Working Party of the European Group for Blood and Marrow Transplantation
Authors: Yeshurun Moshe , Labopin Myriam , Blaise Didier , Cornelissen Jan J. , Sengeloev Henrik , Vindelov Lars , Kuball Juergen , Chevallier Patrice , Craddock Charles , Socie Gerard , Bilger Karin , Schouten Harry C. , Fegueux Nathalie , Goker Hakan , Maertens Johan , Bunjes Donald , Arnold Renate , Nagler Arnon , Mohty Mohamad 
Published: December 2013

BACKGROUNDThe objective of the current study was to investigate the role of postremission consolidation chemotherapy before reduced‐intensity conditioning (RIC) allogeneic stem cell transplantation (alloSCT) for patients with acute myeloid leukemia (AML) in first complete remission (CR1).METHODSOf the 789 consecutive patients with AML in CR1 who underwent RIC alloSCT from a human leukocyte antigen‐matched sibling or matched unrelated donor peripheral stem cell grafts between 2001 and 2010, 591 patients received at least 1 cycle of consolidation chemotherapy and 198 patients did not receive any consolidation chemotherapy before alloSCT. To minimize inherent survival bias in favor of patients who underwent transplant long after achieving CR1, the study focused on 373 patients who underwent transplant within the median time frame between achievement of CR1 and alloSCT (3 months for patients who underwent alloSCT from matched siblings and 4 months for patients who underwent alloSCT from matched unrelated donors). In this subgroup, 151 patients did not receive any consolidation chemotherapy and 222 patients received ≥ 1 consolidation chemotherapy cycle.RESULTSWith a median follow‐up of 36 months (range, 2 months‐135 months), the 3‐year cumulative recurrence incidence (RI) was not significantly different between the groups (36% ± 4% for the group treated without consolidation chemotherapy vs 38% ± 3% for patients who received consolidation chemotherapy;P = .89). In addition, leukemia‐free survival was similar between the groups (45% ± 4% and 47% ± 3%, respectively;P = .41). Dose intensity of cytarabine given during consolidation chemotherapy appeared to have no influence on RI. On multivariate analysis, pretransplant consolidation (≥ 1 cycle vs 0 cycles) was found to have no significant impact on RI (hazards ratio, 1.29; 95% confidence interval, 0.84‐1.97 [P = .24]) or leukemia‐free survival (hazards ratio, 1.00; 95% confidence interval, 0.71‐1.42 [P = .99]).CONCLUSIONSThe data from the current study suggest no apparent advantage for postremission consolidation chemotherapy before RIC alloSCT, provided a donor is readily available.Cancer2014;120:855–863. ©2013 American Cancer Society.
Multicolor detection of rare tumor cells in blood using a novel flow cytometry‐based system
Authors: Watanabe Masaru , Uehara Yuri , Yamashita Namiko , Fujimura Yuu , Nishio Kaori , Sawada Takeshi , Takeda Kazuo , Koizumi Fumiaki , Koh Yasuhiro 
Published: December 2013

AbstractThe presence and number of circulating tumor cells (CTCs) in the blood of patients with solid tumors are predictive of their clinical outcomes. To date, the CellSearch system is the only US Food and Drug Administration‐approved CTC enumeration system for advanced breast, prostate, and colon cancers. However, sensitivity issues due to epithelial cellular adhesion molecule (EpCAM)‐based enrichment and limited capability for subsequent molecular analysis must be addressed before CTCs can be used as predictive markers in the clinical setting. We have developed a multicolor CTC detection system using cross‐contamination‐free flow cytometry, which permits the enumeration and characterization of CTCs for multiple molecular analyses. Tumor cell lines with different expression levels of EpCAM were spiked into peripheral blood obtained from healthy donors. Spike‐in samples were negatively enriched using anti‐CD45‐coated magnetic beads to remove white blood cells, and this was followed by fixation and labeling with CD45‐Alexa Fluor 700, EpCAM‐phycoerythrin, cytokeratin (CK)‐fluorescein isothiocyanate antibodies, and/or 7‐aminoactinomycin D for nuclei staining. Excellent detection (slope = 0.760–0.888) and a linear performance (R2 = 0.994–0.998) were noted between the observed and expected numbers of tumor cells, independent of EpCAM expression. The detection rate was markedly higher than that obtained using the CellSearch system, suggesting the superior sensitivity of our system in detecting EpCAM− tumor cells. Additionally, the incorporation of an epithelial–mesenchymal transition (EMT) marker allowed us to detect EpCAM−/CK− cells and EMT‐induced tumor cells. Taken together, our multicolor CTC detection system may be highly efficient in detecting previously unrecognized populations of CTCs. © 2013 International Society for Advancement of Cytometry
Eating disorder examination questionnaire: Factor structure for adolescent girls and boys
Authors: White Hannah J. , Haycraft Emma , Goodwin Huw , Meyer Caroline 
Published: December 2013

ABSTRACTObjectiveTo examine the factor structure of the EDE‐Q among a sample of adolescents.MethodA community‐based sample of 917 adolescents (522 girls and 395 boys) aged 14–18 years completed the EDE‐Q version 6.0 as part of a larger study. Participants were randomly assigned to one of two subsamples to enable separate analyses.ResultsA confirmatory factor analysis on the original four factor model of the EDE‐Q produced an inadmissible model with a poor fit. Exploratory factor analysis using principal axis factoring produced an alternative three factor model of the EDE‐Q among adolescents. The Shape and Weight Concerns, Restriction and Preoccupation and Eating Concern subscales accounted for 65% of the total variance. Subscale and global scores were significantly higher for girls than for boys. A high proportion of both girls (53.6%) and boys (30.5%) reported participating in at least one key eating disordered behaviour during the previous 28 days.DiscussionThe results of this study present three new subscales (Shape and Weight Concerns, Restriction and Preoccupation and Eating Concern) which are suggested for use in future research which uses the EDE‐Q with community samples of adolescents. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:99–104)
MagicNET: mobile agents data protection system
Authors: Shibli Muhammad Awais , Masood Rahat , Ghazi Yumna , Muftic Sead 
Published: December 2013

AbstractLiterature study and analysis on mobile agents reveal many challenging and uncovered aspects that still do not have comprehensive solutions. Despite the fact that significant research has been carried out on mobile agents, it is still not widely adopted by industry and research community because of the immaturity of various technical aspects of agent paradigm. One of the main reasons that limits the scope of the potential applications of mobile agents is the lack of reliable security solutions for mobile agents’ code and their baggage. The protection of mobile agents’ codes has been solved by the research community to some extent; however, there is not even a single solution that provides complete protection and access control mechanism for agents’ code and their baggage (data being accumulated/ carried by agent during execution). Most of the existing solutions such as execution tracing, code obfuscation, encrypted code execution and partial result encapsulation mainly cover security threats of mobile agents’ code. In this paper, we present a security solution to overcome the security threats on traditional mobile agents computing paradigm. Our proposed solution is one step ahead of extant solutions in that it provides complete protection and enforces access control on agents’ complex baggage structure. We have extended our previous work that was limited to the protection of agents and the agent platforms only. Our approach provides holistic access control mechanism between users and agents, agents and agent platform resources and platform and agents baggage. By adopting the proposed solution in the mobile agent‐oriented software engineering, secure and complex mobile agent‐based applications can be developed, which will greatly benefit the software industry. Copyright © 2013 John Wiley & Sons, Ltd.
Design Principles for Data Visualization in Evaluation
Authors: Evergreen Stephanie , Metzner Chris 
Published: December 2013

AbstractData visualization is often used in two main ways—as a tool to aid analysis or as a tool for communication. In the context of this issue, in this chapter we are focusing on the latter. At its most essential, the communication goal of data visualization is to grab audience attention and help them engage with the data such that the resulting product is increased understanding, regardless of the software platform or programming ability of the author. © Wiley Periodicals, Inc., and the American Evaluation Association.
Synthetic niches for differentiation of human embryonic stem cells bypassing embryoid body formation
Authors: Liu Yarong , Fox Victoria , Lei Yuning , Hu Biliang , Joo Kye‐Il , Wang Pin 
Published: December 2013

AbstractThe unique self‐renewal and pluripotency features of human embryonic stem cells (hESCs) offer the potential for unlimited development of novel cell therapies. Currently, hESCs are cultured and differentiated using methods, such as monolayer culture and embryoid body (EB) formation. As such, achieving efficient differentiation into higher order structures remains a challenge, as well as maintaining cell viability during differentiation into homogeneous cell populations. Here, we describe the application of highly porous polymer scaffolds as synthetic stem cell niches. Bypassing the EB formation step, these scaffolds are capable of three‐dimensional culture of undifferentiated hESCs and subsequent directed differentiation into three primary germ layers. H9 hESCs were successfully maintained and proliferated in biodegradable polymer scaffolds based on poly (lactic‐co‐glycolic acid) (PLGA). The results showed that cells within PLGA scaffolds retained characteristics of undifferentiated pluripotent stem cells. Moreover, the scaffolds allowed differentiation towards the lineage of interest by the addition of growth factors to the culture system. The in vivo transplantation study revealed that the scaffolds could provide a microenvironment that enabled hESCs to interact with their surroundings, thereby promoting cell differentiation. Therefore, this approach, which provides a unique culture/differentiation system for hESCs, will find its utility in various stem cell‐based tissue‐engineering applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 102B: 1101–1112, 2014.
Trabecular bone structure in the primate wrist
Authors: Schilling Ann‐Marie , Tofanelli Sergio , Hublin Jean‐Jacques , Kivell Tracy L. 
Published: December 2013

ABSTRACTTrabecular (or cancellous) bone has been shown to respond to mechanical loading throughout ontogeny and thus can provide unique insight into skeletal function and locomotion in comparative studies of living and fossil mammalian morphology. Trabecular bone of the hand may be particularly functionally informative because the hand has more direct contact with the substrate compared with the remainder of the forelimb during locomotion in quadrupedal mammals. This study investigates the trabecular structure within the wrist across a sample of haplorhine primates that vary in locomotor behaviour (and thus hand use) and body size. High‐resolution microtomographic scans were collected of the lunate, scaphoid, and capitate in 41 individuals and eight genera (Homo, Gorilla, Pan, Papio, Pongo, Symphalangus, Hylobates, and Ateles). We predicted that particular trabecular parameters would 1) vary across suspensory, quadrupedal, and bipedal primates based on differences in hand use and load, and 2) scale with carpal size following similar allometric patterns found previously in other skeletal elements across a larger sample of mammals and primates. Analyses of variance (trabecular parameters analysed separately) and principal component analyses (trabecular parameters analysed together) revealed no clear functional signal in the trabecular structure of any of the three wrist bones. Instead, there was a large degree of variation within suspensory and quadrupedal locomotor groups, as well as high intrageneric variation within some taxa, particularly Pongo and Gorilla. However, as predicted, Homo sapiens, which rarely use their hands for locomotion and weight support, were unique in showing lower relative bone volume (BV/TV) compared with all other taxa. Furthermore, parameters used to quantify trabecular structure within the wrist scale with size generally following similar allometric patterns found in trabeculae of other mammalian skeletal elements. We discuss the challenges associated with quantifying and interpreting trabecular bone within the wrist. J. Morphol. 275:572–585, 2014. © 2013 Wiley Periodicals, Inc.
Inferring Chemogenomic Features from Drug‐Target Interaction Networks
Authors: Yamanishi Yoshihiro 
Published: December 2013

AbstractDrug effects are mainly caused by the interactions between drug molecules and target proteins including primary targets and off‐targets. Understanding of the molecular mechanisms behind overall drugtarget interactions is crucial in the drug design process. In this paper we review recently developed methods to infer chemogenomic features (the underlying associations between drug chemical substructures and protein domains) which are strongly involved in drug‐target interaction networks. We show the usefulness of the methods to detect ligand chemical fragments specific for each protein domain and ligand core substructures important for a wide range of protein families. We also discuss how to use the chemogenomic features for predicting unknown drug‐target interactions on a large scale.
Developing production schedules which balance part usage and smooth production loads for just‐in‐time production systems
Authors: Miltenburg G.J. , Goldstein T. 
Published: December 2013

AbstractA mixed‐model multilevel manufacturing facility running under a just‐in‐time (JIT) production system is controlled by setting the production schedule for the highest level in the facility, which is usually a mixed‐model final assembly line. The schedule is set to achieve the goals of the organization, which under JIT are (1) to keep a constant rate of part usage, and (2) to maintain a smooth production load. In this article we extend earlier work in the literature, which focused on the first goal, by developing scheduling procedures which satisfy both goals. Properties of the resulting production schedules are analyzed and illustrative examples are presented.
Intramolecular carbolithiation‐cyclization‐electrophilic substitution: solvent effect and mechanistic study
Authors: Rodriguez Cristian , Nudelman Norma Sbarbati 
Published: December 2013

The intramolecular carbolithiation‐cyclization‐electrophilic substitution sequence proves to be a promising strategy for synthetic organic chemists. Our current research in this area focuses on the one‐pot halogen/lithium exchange of 2‐bromophenyl‐3‐phenylprop‐2‐enyl ether, followed by intramolecular carbolithiation, and trapping of the new lithiated cyclic intermediate by several electrophiles, affording 3‐substituted 2,3‐dihydrobenzofurans with some diastereoselectivity. Within this context, a study on the product distribution solvent dependence was carried out using different types of solvents, namely: polar coordinating, polar non‐coordinating, and non‐polar solvents. The results show that the coordinating features of the solvent affect specially the carbolithiation step, whereas the halogen/lithium exchange seems to be barely affected.Theoretical calculations were carried out to investigate the unexpected diastereoselectivity of the tandem reaction, where two stereocenters are generated. Insights gained from our mechanistic investigations enabled us to propose an inversion of configuration at the lithiated intermediate prior to the reaction, being the electrophile the likely cause for the observed distereoselectivity. Copyright © 2013 John Wiley & Sons, Ltd.