bluuebunny/crossref_metadata_2025_split huggingface dataset:
Eating behaviors and negative affect in college women's everyday lives
Authors: Heron Kristin E. , Scott Stacey B. , Sliwinski Martin J. , Smyth Joshua M. 
Published: May 2014

ABSTRACTObjectiveA growing body of research seeks to understand the relationship between mood and eating behaviors. Ecological Momentary Assessment (EMA) methods provide a method for assessing these processes in natural settings. We used EMA to examine the relationship between mood and eating behaviors in everyday life among women with subclinical disordered eating behaviors.MethodParticipants (N = 127, age M = 19.6 years, BMI M = 25.5) completed five daily EMA reports on palmtop computers for 1 week. Assessments included measures of negative affect (NA) and eating‐related behavior during eating (eating large amounts of food, loss of control over eating, and restricting food intake) and noneating episodes (skip eating to control weight/shape). Time‐lagged multilevel models tested mood–eating behavior relationships.ResultsHigher NA did not precede any unhealthy eating and weight control behaviors. However, NA was higher when women reported eating large quantities of food, losing control over eating, and restricting food intake during their most recent eating episode, but not after skipping eating to control weight/shape.DiscussionThese findings elucidate the processes in daily life that may influence the development and maintenance of unhealthy eating and weight control behaviors that, in turn, can inform interventions. © 2014 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:853–859)
Mating system variation drives rapid evolution of the female transcriptome in Drosophila pseudoobscura
Authors: Immonen Elina , Snook Rhonda R. , Ritchie Michael G. 
Published: May 2014

AbstractInteractions between the sexes are believed to be a potent source of selection on sex‐specific evolution. The way in which sexual interactions influence male investment is much studied, but effects on females are more poorly understood. To address this deficiency, we examined gene expression in virgin female Drosophila pseudoobscura following 100 generations of mating system manipulations in which we either elevated polyandry or enforced monandry. Gene expression evolution following mating system manipulation resulted in 14% of the transcriptome of virgin females being altered. Polyandrous females elevated expression of a greater number of genes normally enriched in ovaries and associated with mitosis and meiosis, which might reflect female investment into reproductive functions. Monandrous females showed a greater number of genes normally enriched for expression in somatic tissues, including the head and gut and associated with visual perception and metabolism, respectively. By comparing our data with a previous study of sex differences in gene expression in this species, we found that the majority of the genes that are differentially expressed between females of the selection treatments show female‐biased expression in the wild‐type population. A striking exception is genes associated with male‐specific reproductive tissues (in D. melanogaster), which are upregulated in polyandrous females. Our results provide experimental evidence for a role of sex‐specific selection arising from differing sexual interactions with males in promoting rapid evolution of the female transcriptome.
Reversible Solvent‐Exchange‐Driven Transformations in Multifunctional Coordination Polymers Based on Copper‐Containing Organosulfur Ligands
Authors: Gallego Almudena , Castillo Oscar , Gómez‐García Carlos J. , Zamora Félix , Delgado Salome 
Published: May 2014

AbstractThe preparation by simple direct synthesis of a series of coordination polymers based on copper with chloride or bromide and dipyrimidinedisulfide is reported. The structural characterisations of these compounds reveal a rich structural variety as a result of the number of coordination modes available to the organosulfur ligand, in combination with the bridging capabilities of the halides. Interestingly, some of the polymers displayed fully reversible solvent exchange/removal crystal‐to‐crystal 2D to 0D and 2D to 2D transformations. These materials show multifunctional electronic properties. Thus, some of them are semiconductors and present weak antiferromagnetic interactions, and the CuI/CuII coordination polymers present coexistence of paramagnetism with weak red emission. These compounds present some of the lowest NIR energy luminescence in d10 transition‐metal complexes.
Variable Nuclearity in Lanthanoid Coordination Chemistry
Authors: Andrews Philip C. , Hennersdorf Felix , Junk Peter C. , Thielemann Dominique T. 
Published: May 2014

AbstractA series of lanthanoid and iodine containing compounds of formulae [Ln(IPhacac)3(dmf)2], [K(dmf)2{Ln(IPhacac)4}]n and [Ln5(OH)5(IPhacac)10] {(IPhacac) = bis(para‐iododibenzoyl)methanide} have been prepared and structurally characterised. X‐ray crystallography establishes that the compounds exist as monomers [Ln(IPhacac)3(dmf)2] {Ln = Pr (1), Nd (2), Tb (5), Dy (6)} and [Yb(IPhacac)3(dmf)2][Yb(IPhacac)3(dmf)(H2O)] (7) (dmf = N,N‐dimethylformamide), polymers [K(dmf)2{Ln(IPhacac)4}]n {Ln = Nd (2a), Eu (3a), Gd (4a), Tb (5a), Dy (6a)} and pentanuclear clusters [Ln5(OH)5(IPhacac)10] {Ln = Tb (5b), Dy (6b), Yb (7b)}.
Determination of Absolute Configurations of Bedaquiline Analogs by Quantum Chemical Electronic Circular Dichroism Calculations and an X‐ray Diffraction Study
Authors: Wang Zhiqiang , Zhao Lixia , Chen Yu , Xu Wei , Sun Tiemin 
Published: May 2014

AbstractTwo chiral analogs of bedaquiline were selected from a series of compounds designed as anti‐Mycobacterium tuberculosis drugs for synthetic and stereochemical research. The compounds were synthesized from chiral precursors for the first time, and the absolute configurations (ACs) were determined by electronic circular dichroism (ECD) and quantum chemical calculations. Single crystals of both compounds were obtained for X‐ray analysis, and the crystal structures and ab initio calculated geometries were extremely similar, which permitted a comparison of the relative reliabilities of ACs obtained by ECD analyses and theoretical simulation. In addition, the in vitro antituberculosis activities of the two compounds were investigated.
Brønsted Acid Catalyzed Bisindolization of α‐Amido Acetals: Synthesis and Anticancer Activity of Bis(indolyl)ethanamino Derivatives
Authors: Mari Michele , Tassoni Aurora , Lucarini Simone , Fanelli Mirco , Piersanti Giovanni , Spadoni Gilberto 
Published: May 2014

AbstractA Brønsted acid catalyzed bisindolization reaction with suitable α‐amido acetals that tolerates a wide range of indoles is reported. The method allows rapid access to the biologically relevant bisindolyl ethanamine scaffold in good to excellent yields upon mild amide basic hydrolysis. In preliminary pharmacological studies, some of these compounds display cytotoxic activity in U937 cancer cells. The marine natural alkaloid 2,2‐di(6′‐bromo‐3′‐indolyl)‐ethylamine was the most active compound and could be a lead candidate for further optimization. For the first time, the biological role of this brominated bisindole marine alkaloid is presented.
Synthesis of Di‐ and Trivalent Carbohydrate Mimetics with Oxepane Substructure by Employing Copper‐Catalyzed [3+2] Cycloadditions of Alkynes with Azido­oxepanes
Authors: Bouché Léa , Reissig Hans‐Ulrich 
Published: May 2014

AbstractA series of enantiopure poly(hydroxy)aminooxepanes was converted into the corresponding azidooxepanes by a safe and efficient copper(II)‐catalyzed diazo transfer reaction employing nonafluorobutanesulfonyl azide as nitrogen donor. These azidooxepanes underwent smooth copper(I)‐catalyzed [3+2] cycloadditions with alkynes (click reaction) to provide a series of simple triazoles. With dialkynes and a trialkyne, bis‐ and tristriazoles containing oxepane substructures were prepared. Due to the polyhydroxylated end groups, these compounds are regarded as carbohydrate mimetics with potential biological activities, for example, as selectin inhibitors. In addition, unsymmetrical systems and macrocyclic compounds were prepared, again by employing [3+2] cycloadditions as key steps.
Aqueous Copper Nitrate Catalyzed Synthesis of 3‐Alkylideneoxindoles from α‐Diazo‐β‐ketoanilides
Authors: Mo Shanyan , Yang Zhanhui , Xu Jiaxi 
Published: May 2014

AbstractAn economical, practical, and green protocol with which to synthesize 3‐alkylideneoxindoles from α‐diazo‐β‐ketoanilides has been developed. The approach employs inexpensive Cu(NO3)2·3H2O as catalyst and environmentally friendly water as solvent, and achieves moderate to excellent yields. The method has good tolerance to a range of N‐alkyl and N‐aryl groups, including electron‐withdrawing and electron‐donating groups on the aromatic ring, ortho‐, meta‐, and para‐substituents, and β‐aliphatic and β‐aromatic keto groups. A plausible mechanism involving intramolecular aromatic metal carbene electrophilic addition as the key step is proposed.
A Novel Electrochemical Sensor Based on a Mixed Diazonium/PEDOT Surface Functionalization for the Simultaneous Assay of Ascorbic and Uric Acids. Towards an Improvement in Amperometric Response Stability
Authors: Richard William , Evrard David , Gros Pierre 
Published: May 2014

AbstractA new electrochemical sensor was developed for the simultaneous assay of 2 major antioxidants, namely ascorbic (AA) and uric (UA) acids in neutral media. The electrode was modified by means of electropolymerized conductive poly(3,4‐ethylenedioxythiophene) (PEDOT) organic films. The stability of the resulting interface was improved thanks to a thiophene‐containing diazonium layer previously grafted onto the glassy carbon substrate. The morphology and electrochemical properties of all PEDOT and diazonium/PEDOT layers were characterized by Field Emission Gun Scanning Electron Microscopy (FEG‐SEM) and cyclic voltammetry (CV). The best analytical performances were obtained for both biomarkers with diazonium electrodeposited under galvanostatic mode and PEDOT generated by CV. Using CV the sensitivities and detection limits were found to be 0.345 µA cm−2 µM−1 and 6 µM for AA and 0.665 µA cm−2 µM−1 and 1.5 µM for UA. The calibration curves were linear in the concentration range 12–1400 µM and 10–1000 µM for AA and UA, respectively. A high selectivity was observed with a detection potential difference more than 250 mV. The sensor exhibited a particularly long lifetime as well in storage (at least 85 % of the initial response recorded after one month) as in operational conditions (more than 80 % recovery after 40 successive measurements).
Electrochemical Detection of miRNAs
Authors: Lautner Gergely , Gyurcsányi Róbert E. 
Published: May 2014

AbstractThe recent progress made in the development of electrochemical methods for microRNA (miRNA) detection is presented. The progress is conceived to be largely due to the invention of novel assay methodologies and the use of various bioreagents and nanostructures. These enable a rigorous control over the sensing interface, provide enormous signal amplifications and single‐base mismatch specificity. Femtomolar or even subfemtomolar detection limits were shown to be feasible by electrochemical assays. Thus electrochemical detection methodologies are of perspective for diagnostic miRNA detection.
Label‐Free Sensing of Biomolecules with Field‐Effect Devices for Clinical Applications
Authors: Poghossian Arshak , Schöning Michael J. 
Published: May 2014

AbstractAmong the variety of transducer concepts proposed for label‐free detection of biomolecules, the semiconductor field‐effect device (FED) is one of the most attractive platforms. As medical techniques continue to progress towards diagnostic and therapies based on biomarkers, the ability of FEDs for a label‐free, fast and real‐time detection of multiple pathogenic and physiologically relevant molecules with high specificity and sensitivity offers very promising prospects for their application in point‐of‐care and personalized medicine for an early diagnosis and treatment of diseases. The presented paper reviews recent advances and current trends in research and development of different FEDs for label‐free, direct electrical detection of charged biomolecules by their intrinsic molecular charge. The authors are mainly focusing on the detection of the DNA hybridization event, antibody‐antigen affinity reaction as well as clinically relevant biomolecules such as cardiac and cancer biomarkers.
Approaches Toward Allowing Electroanalytical Devices to be Used in Biological Fluids
Authors: Barfidokht Abbas , Gooding J. Justin 
Published: May 2014

AbstractBiofouling on surfaces can deleteriously affect the function of electrochemical sensor used in a biological fluid. The demand is thus to develop a sensor operatable in complex matrices. Herein, we concisely review the technologies developed to date to minimize fouling of electrochemical interfaces by blood‐based fluids with an emphasis on affinity biosensing. The methods toward this sensor fabrication that are discussed here include approaches where; chemically modified surfaces with antifouling layers such as ethylene oxides, zwitterionics and some alternative antifouling agents; physical forces such as fluidic systems; electrode surface topography, prevent biofouling, as well as recent approaches where biofouling does not interfere with the response (aptasensors). Furthermore, the important emerging field of implantable biosensors, originated from such fabrication procedures is discussed.
Fire safety and evacuation implications from behaviours and hazard development in two fatal care home incidents
Authors: Purser David A. 
Published: May 2014

SummaryTwo fatal care home fires, Rosepark, involving multiple deaths, and a Lincolnshire Residential Home, involving one fatality in the fire enclosure, are examined for fire scenario development and occupant behaviours. Compartmentation in both premises provided greater than 30‐min protection from smoke penetration for closed rooms but was compromised by open rooms. Safety then depended on staff response. At the Lincolnshire Home, staff rapidly investigated and isolated the fire, resulting in a local fatality but protecting other occupants. At Rosepark, the open fire enclosure (a cupboard) affected ten open occupied bedrooms in two subcompartments. Training inadequacies resulted in failure to identify the fire location and close room doors, leading to multiple deaths within 9 min, and reporting delays. These incidents and others show common features involving fire and smoke spread from open rooms exposing occupants in other open rooms and staff failing to close doors while involved in other activities. With well‐trained staff, safety can be provided by fire‐resisting construction, incorporating subcompartments with few bedrooms and free‐swing, fire‐rated doors, with smoke seals and automatic closure. These protect all occupants beyond the fire enclosure so that members of the staff are free to attend those immediately affected. Sprinklers provide further protection, particularly for occupants and members of the staff near the fire. Copyright © 2014 John Wiley & Sons, Ltd.
Synthesis of 1,3,4‐Oxadiazole‐Based Aromatic and Heterocyclic/Phenylpyrazole Derivatives
Authors: Wang Li‐Ya , Chang En‐Chiuan , Yeh Mou‐Yung , Chung Yu Hsuan , Huang Jiann‐Jyh , Wong Fung Fuh 
Published: May 2014

ABSTRACTA new series of 1,3,4‐oxadiazole‐based aromatic and heterocyclic/phenylpyrazole derivatives 6a–c, 7a–d, and 8 were synthesized via sequential 1,3‐dipolar cyclization, hydrazidation, benzoylation, dehydrative cyclization, and the Suzuki coupling reaction. Among the derivatives, compounds 7a and 7c with the corresponding 2‐thienyl and 2‐benzo[b]thienyl (Ar) at the phenyl group located at the N‐1 position of pyrazole showed a better conjugation range.
Phosphorylated Aminoacetal in the Synthesis of New Acyclic, Cyclic, and Heterocyclic Polyphenol Structures
Authors: Vagapova Liliya I. , Burilov Alexander R. , Voronina Julia K. , Syakaev Victor V. , Sharafutdinova Dilyara R. , Amirova Lyaysan R. , Pudovik Michael A. , Garifzyanov Airat R. , Sinyashin Оleg G. 
Published: May 2014

ABSTRACTNew phosphorylated aminoacetal has been synthesized by the Kabachnik–Fields reaction; its reactivity has been studied in acid‐catalyzed condensation with linear polyphenols (2‐methylresorcinol, resorcinol, pyrogallol) and the Mannich reaction with macrocyclic polyphenol (calix[4]resorcinol). It has been determined for the first time that acid‐catalyzed reaction of phosphorus‐containing acetal with resorcinol and its derivatives in ethanol in the presence of hydrochloric acid gives new phosphorylated piperazines in addition to the compounds of diarylmethane series. Condensation of macrocyclic polyphenol (calix[4]resorcinol) with formaldehyde and N‐((dihexylphosphoryl)methyl)‐2, 2‐dimethoxyethylamine (the Mannich reaction) has resulted in novel tetrasubstituted calixarene containing aminophosphine oxide and acetal groups on the “upper rim” of molecule.
Androcin, a novel type of cysteine‐rich venom peptide from Androctonus bicolor, induces akinesia and anxiety‐like symptoms in mice
Authors: Yang Ye , Zeng Xian‐Chun , Zhang Lei , Nie Yao , Shi Wanxia , Liu Yichen 
Published: May 2014

AbstractA novel type of venom peptide with six disulfide bridges, referred to as Androcin, was identified from the scorpion Androctonus bicolor using a cDNA library strategy. The amino acid sequence of Androncin displays little identity to other known peptides from scorpions. We found that the genomic sequence of Androcin consists of three exons interrupted by two introns that are localized in the signal sequence and mature peptide encoding regions, inserted in phase 2 and phase 0, respectively. This genomic organization is unique among those of the cysteine‐rich peptides from scorpions described so far. The primary and secondary structures of Androcin are homologous to those of the N‐terminal domains of insulin‐like growth factor‐binding proteins; this suggests that Androcin may block the normal function of IGFs. Toxicological analysis using the recombinant Androcin peptide revealed that Androcin is able to induce severe akinesia and anxiety‐like symptoms in mice. Androcin is a novel mammalian toxin with six disulfide bridges that provides the scorpion with another tool to subdue animals. © 2014 IUBMB Life, 66(4):277–285, 2014
In‐vitro Aluminum Determination and Preconcentration in Blood of Dialysis Patients Based on Ionic Liquid Dispersive Liquid‐Liquid Biomicroextraction by 2‐Amino‐3‐(1H‐imidazol‐4‐yl)propanoic Acid
Authors: Shirkhanloo H. , Mousavi H. Z. , Mohamadi M. 
Published: May 2014

AbstractIn this study, trace amounts of aluminum in serum of dialysis patients were chelated with 2‐Amino‐3‐(1H‐imidazol‐4‐yl)propanoic acid (Histidine) and determined by electro‐thermal atomic absorption spectrometry (ETAAS). A fast and efficient method based on ionic liquid dispersive liquid‐liquid bio‐micro‐extraction (IL‐DLLBME) was developed for the determination of Al cation in human blood serum samples. In this work, a small amount of 1‐Hexyl‐3‐methylimmidazolum hexafluorophosphate ([HMIM] [PF6]) as an extractant solvent was dissolved in acetone as a dispersant solvent and then the binary solution was rapidly injected by a syringe into the serum containing Al3+,Which have already in‐vitro chelated by Histidine amino acid (Al‐His) at pH = 6.5. After separation, the settled IL‐phase was dissolved in ethanol up to 200 μL and 20 μL of samples injected into the ET‐AAS by auto‐sampler. Various parameters have been studied and optimized for 10 mL of sample. Under the optimum conditions, the enrichment factor (EF), limit of detection (LOD) and working range (peak area mode) were obtained 53, 15 ng L−1 and 0.05‐4.1 μg L−1 respectively. In vitro Al chelation showed that His can significantly decrease aluminum concentration in serum of dialysis patients. Validation of methodology was confirmed by standard reference material (SRM).
Solvent‐Free Sonochemical Synthesis and Antifungal Activity of 1‐Alkyl‐3‐Methylimidazolium Bromide [RMIM]Br Ionic Liquids
Authors: Perez Ser John Lynon P. , Arco Susan D. 
Published: May 2014

AbstractIn view of the continuous threat of opportunistic fungal infections to human health and the emerging importance of ionic liquids in therapeutic applications, we report the efficient one‐pot synthesis of a series of 1‐alkyl‐3‐methylimidazolium bromide [RMIM]Br ionic liquids through an ultrasound‐assisted reaction of 1‐methylimidazole and alkyl bromides (RBr) under solvent‐free conditions. High product yields were obtained for all syntheses (>95%) under mild conditions (2‐5 hours at 20‐40 °C). The success of the synthetic method was confirmed through 1H‐NMR, 13C‐NMR and FT‐IR spectroscopy. All products exhibited activity against the fungus C. albicans with clotrimazole and water as positive and negative controls, respectively. At a concentration of 1%, [OMIM]Br IL exhibited an antimycotic activity with an index of 1.5 which is comparable to that of 1% clotrimazole having an antimicrobial index of 1.3, signifying the potential of the product as a fungal growth inhibitor. Structure‐Activity Relationship (SAR) studies showed that an increase in the alkyl chain length corresponds to an increase in the antifungal activity of the ionic liquids.
Property and Application of BACy‐Based Functional Hydrogels
Authors: Lin Yan‐Su , Huang Yi‐Long , Lee Wen‐Fu , Lin Chao‐Hsiung 
Published: May 2014

AbstractConventional polyacrylamide hydrogels prepared from the free radical polymerization between acrylamide and N,N′‐methylenebisacrylamide (NMBA) have been frequently used in the biochemical technique like the sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS‐PAGE) to resolve protein mixtures. In this study, we have prepared an alternative polyacrylamide hydrogel from the cross‐linking of acrylamide and N,N′‐bisacrylylcystamine (BACy). In addition, we have compared the BACy‐based hydrogel with the NMBA‐based polyacrylamide hydrogel for their physical properties such as swelling ratio, shear modulus, crosslink density and morphology. Moreover, we further determined whether BACy‐based polyacrylamide hydrogel could be applied to SDS‐PAGE and proteomics research. The results showed that this type of hydrogel is capable of separating proteins and facilitates further in‐gel protein digestion and the following protein identifications by mass spectrometry. In summary, our study provides a basis for the putative application of BACy‐based hydrogels.
Evaluation of the Utility of Serum Prolidase as a Marker for Liver Fibrosis
Authors: Stanfliet John C. , Locketz Michael , Berman Peter , Pillay Tahir S. 
Published: May 2014

BackgroundLiver dysfunction is common and often unrecognized. Liver biopsy is the gold standard in the assessment of liver fibrosis, but has disadvantages. We assessed the diagnostic accuracy of serum prolidase enzyme activity (SPA) in predicting the presence and degree of liver fibrosis, as compared with liver biopsy. Further, we evaluated the effect of hemolysis on measured SPA levels.MethodsWe undertook a prospective case control study. Thirty eight outpatients without apparent liver illness and 20 patients with liver pathology scheduled to undergo liver biopsy had their SPA levels measured.ResultsPatients undergoing liver biopsy had higher SPA levels (361 (268) IU/l [median (interquartile range)]) compared with controls (169 (160) (P < 0.001)). A SPA cutoff value of 200 IU/l yielded a sensitivity of 89%, specificity of 59%, an odds ratio of 11.5, negative predictive value of 92%, and a positive predictive value of 50%. Hemolysis causes an apparent increase in SPA levels.ConclusionHigher SPA levels in patients undergoing liver biopsies compared with controls may reflect the presence of liver fibrosis. SPA levels could not be used to stage the degree of fibrosis. SPA measurement may be useful in the diagnostic workup of suspected liver disease.