bluuebunny/crossref_metadata_2025_split huggingface dataset:
Nuclear receptor E75/NR1D2 drives tumor malignant transformation by integrating Hippo and Notch pathways
Authors: Wang Xianping , Guo Yifan , Lin Peng , Yu Min , Song Sha , Xu Wenyan , Kong Du , Wang Yin , Zhang Yanxiao , Lu Fei , Xie Qi , Ma Xianjue 
Published: June 2024

AbstractHormone therapy resistance and the ensuing aggressive progression of tumors present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy by hormone inhibition remain poorly understood. Here we show thatDrosophilamalignant epithelial tumors exhibit a comparable decrease in ecdysone signaling, the primary steroid hormone pathway inDrosophila. Furthermore, we find that ectopic expression of the nuclear receptorE75partially mimics ecdysone signaling inhibition, specifically promoting the malignant transformation of benign tumors by integrating the Hippo and Notch signaling pathways. Genome-wide DNA binding profiles and biochemistry data reveal that E75 not only physically interacts with the transcription factors of both Hippo and Notch pathways, but also exhibits widespread co-binding to their target genes, thus contributing to tumor malignancy. Moreover, we validate these findings by demonstrating that depletion ofNR1D2, the mammalian equivalent of E75, inhibits the activation of Hippo and Notch target genes, impeding glioblastoma progressionin vivo. In summary, our study unveils a previously unrecognized mechanism by which hormone inhibition promotes tumor malignant transformation, while providing a conserved mechanistic understanding of how Hippo and Notch pathways are integrated by the oncogene E75/NR1D2 during tumor progression.
Improving Circulation Half-Life of Therapeutic Candidate N-TIMP2 by Unfolded Peptide Extension
Authors: Shirian Jason , Hockla Alexandra , Gleba Justyna J. , Coban Matt , Rotenberg Naama , Strik Laura M. , Alasonyalilar Demirer Aylin , Pawlush Matt L. , Copland John A. , Radisky Evette S. , Shifman Julia M. 
Published: June 2024

AbstractMatrix Metalloproteinases (MMPs) are drivers of many diseases including cancer and are established targets for drug development. Tissue inhibitors of metalloproteinases (TIMPs) are human proteins that inhibit MMPs and are being pursued for the development of anti-MMP therapeutics. TIMPs possess many attractive properties of a drug candidate, such as complete MMP inhibition, low toxicity and immunogenicity, high tissue permeability and others. A major challenge with TIMPs, however, is their formulation and delivery, as these proteins are quickly cleared from the bloodstream due to their small size. In this study, we explore a new method for plasma half-life extension for the N-terminal domain of TIMP2 (N-TIMP2) through appending it with a long intrinsically unfolded tail containing a random combination of Pro, Ala, and Thr (PATylation). We design, produce and explore two PATylated N-TIMP2 constructs with a tail length of 100- and 200-amino acids (N-TIMP2-PAT100and N-TIMP2-PAT200, respectively). We demonstrate that both PATylated N-TIMP2 constructs possess apparent higher molecular weights compared to the wild-type protein and retain high inhibitory activity against MMP-9. Furthermore, when injected into mice, N-TIMP2-PAT200exhibited a significant increase in plasma half-life compared to the non-PATylated variant, enhancing the therapeutic potential of the protein. Thus, we establish that PATylation could be successfully applied to TIMP-based therapeutics and offers distinct advantages as an approach for half-life extension, such as fully genetic encoding of the gene construct, mono-dispersion, and biodegradability. Furthermore, PATylation could be easily applied to N-TIMP2 variants engineered to possess high affinity and selectivity toward individual MMP family members, thus creating attractive candidates for drug development against MMP-related diseases.
Observation of a magneto-Rayleigh-Taylor instability in magnetically collimated plasma jets
Authors: Malko S. , Schaeffer D. B. , Yao W. , Valenzuela-Villaseca V. , Johnson C. , Fiksel G. , Ciardi A. , Fox W. 
Published: June 2024

We present the direct experimental observation of the formation of a diamagnetic cavity and magneto-Rayleigh-Taylor (MRT) instability in a β≈1 high energy density plasma. Proton radiography is used to measure the two dimensional path-integrated magnetic field in a laser-produced plasma propagating parallel to a preimposed magnetic field. Flutelike structures, associated with the MRT instability, are observed to grow at the surface of the cavity, with a measured wavelength of 1.2 mm and growth time of 4 ns. These measurements are in good agreement with predictions of three dimensional magnetohydrodynamic simulations using the GORGON code.

Published by the American Physical Society
2024
Sustainable competitive advantage under digital transformation: an eco-strategy perspective
Authors: Du Xiaomin , Wang Nuoyan , Lu Shan , Zhang Ao , Tsai Sang-Bing 
Published: June 2024

Purpose
This study aims to investigate how a firm’s sustainable competitive advantage is influenced by the combination of entrepreneurial ecological orientation, digital transformation and dynamic capabilities.

Design/methodology/approach
Based on the qualitative comparative analysis method, this study systematically explores the significant key conditions and configuration effects that affect the growth of sustainable competitive advantage. This study uncovers the causal relationship and complex mechanisms underlying the sustainable and unsustainable competitive advantages for new ventures, by examining the grouping effects of the above three factors – entrepreneurial ecological orientation, digital transformation and dynamic capabilities on those advantages.

Findings
A single factor fails to constitute a necessary condition for sustainable competitive advantage. Three types of configurations are beneficial to sustainable competitive advantage, namely, flexible and responsive type, dynamically adjusted type and type of opportunity resource integration, whereas four types of configurations lead to the unsustainable competitive advantage of new ventures, namely, type of organizational rigidity, informal entrepreneurial type, information-blocking type and technology-deficient type.

Originality/value
According to this study, adopting an entrepreneurial ecological orientation is a novel strategic move. This study offers an extensive review of three aspects of entrepreneurial ecological orientation, dynamic capacities and digital transformation and their mutually synergistic cascading effects on the sustainable competitive advantage of new ventures. This study investigates how three dimensions interact to achieve sustainable competitive advantage for firms, ultimately contributing to the study of sustainable competitive advantage strategies from an entrepreneurial ecosystem perspective.
Fröhlich model characterization of magnetic properties of the induction heating load
Authors: Lahuerta Óscar , Ortega José , Carretero Claudio , Martínez Juan Pablo , Acero Jesús 
Published: June 2024

Purpose
The purpose of this paper is the identification of the magnetic characteristics of the induction load by means of the B–H curve proposed by Fröhlich.

Design/methodology/approach
An electromagnetic description of the inductor system is performed to substitute the effects of the induction load, for a mathematical condition, the so-called impedance boundary condition (IBC).

Findings
A significant reduction in the computational cost of electromagnetic simulation has been achieved through the use of the IBC, resulting in a computation time approximately 400 times faster than time domain simulation. Moreover, an alternative method has been developed to experimentally identify the parameters that determine the magnetic behavior of the induction load. Finally, further research has been conducted to understand the relationship between the equivalent impedance of an induction load and the excitation current level.

Practical implications
This work is performed to achieve a better understanding of the fundamentals involved in the electromagnetic modeling of an induction heating system.

Originality/value
This paper introduces the dependence on the excitation level based on a first harmonic approximation and extends the IBC to nonlinear magnetic materials which allows the identification of the magnetic characteristics of the induction load.
Co-creating impact: positioning indigenous knowledge holders as expert researchers
Authors: Fitzsimmons Terrance , Yates Miriam S. , Jordan Ree , Callan Victor J. 
Published: June 2024

PurposeThis article details a research approach that created impact through suspending assumptions of Western research methods and positioning Indigenous research partners as experts and co-creators of the research process.Design/methodology/approachThe research partnership placed Indigenous ways of knowing, being and doing at the center of research design and methodological choices. At all decision-making points upon commencement of the research, Indigenous (non-academic) research partners were engaged and determined the outcomes of the research partnership.FindingsThe impact of this research partnership was three-fold. First, this partnership impacted women directly through employment of Australian Indigenous Environmental Rangers as research associates. Second, the partnership increased awareness and collectivism of Indigenous women’s voices as leaders and advocates for policy change, bringing a new cohort of women rangers wishing to participate as research associates in the project. Third, was the establishment of a National Forum and the formal application for a $1,000,000 Australian Research Council Linkage Project grant to continue research at the National Forum.Originality/valueWe offer readers the opportunity to observe our process of engaging in effective research collaborations with Australian Indigenous peoples who are typically not included as co-creators and equal partners in Western academic research. The research collaboration centered upon Indigenous ways of knowing, being and doing to amplify impact. We demonstrate the impact of framing the research as storytelling, so enabling data collection through the culturally safe methods of “dadirri” as well as the “yarning circle”, both of which privilege Indigenous knowledge systems.
Examining moral identity and engagement with sustainable consumption at home and in the workplace
Authors: Salciuviene Laura , Dovalienė Aistė , Gravelines Žaneta , Vilkas Mantas , Oates Caroline , Banytė Jūratė 
Published: June 2024

PurposeThe study aims to identify the effects of consumer moral identity and consumer engagement with sustainable consumption on sustainable consumer behaviour at home and in the workplace.Design/methodology/approachSurvey data were collected in two European countries, i.e. Lithuania and the United Kingdom (total sample 586) and analysed using PLS-SEM to test hypotheses pertaining to the key variables, including moral identity, engagement with sustainable consumption, sustainable consumption behaviour at home and sustainable consumption behaviour in the workplace.FindingsRevealed that moral identity was a predictor of sustainable consumption behaviour at home but had no direct effect on sustainable consumption behaviour at the workplace. Similarly, engagement with sustainable consumption has been demonstrated to have a direct positive impact on sustainable consumption behaviour at home, but no significant effect on sustainable behaviour at work was confirmed. A strong moral identity fosters higher consumer engagement with sustainable consumption. The findings revealed the positive impact of sustainable behaviour at home on equivalent behaviour at work, reminding of the importance of the so-called “spill-over” effect.Originality/value An element of novelty in this study lies in the differentiation of behavioural practices at home and in the workplace, demonstrating that a spill-over effect can occur with a “home-work” path. By highlighting the importance of consumer moral identity and consumer engagement in predicting sustainable consumption behaviour in both domestic and professional settings, our study contributes to the advancement of knowledge in the fields of sustainable marketing and consumer behaviour.
Workplace accidents, economic determinants and underreporting: an empirical analysis in Italy
Authors: Antonelli Maria Alessandra , Castaldo Angelo , Forti Marco , Marrocco Alessia , Salustri Andrea 
Published: June 2024

PurposeThis paper proposes an analysis of occupational accidents in Italy at the regional level. For this purpose, our panel is composed of 20 regions over the 2010–2019 time span.Design/methodology/approachWe apply different econometric estimation techniques (pooled OLS model, panel fixed and random effects models and semiparametric fixed model) using INAIL and ISTAT data. Our models investigate workplace accidents at the regional level by accounting for socioeconomic, labour market and productive system variables and controlling for possible underreporting bias.FindingsOverall results reveal the existence of a relevant under-notification phenomenon of accidents at work with respect to moderate accidents, that is higher especially for the southern regions of Italy. However, when considering as outcome variable an alternative set of more severe workplace accidents our model specification remains highly jointly statistically significant. Among our main findings, the analysis shows that worker skills (blue collar) strongly affect the regional pattern of workplace accidents, i.e. an increase of 1% of low paid employees generates about an increase of 1.8 severe workplace accidents per thousand workers. Moreover, we provide evidence that the size of the firm is inversely related to the occupational accident rates. Finally, our results highlight a nonlinear relationship between GDP and occupational accidents for the Italian regional context, confirmed by the high statistical significance of the quadratic term in all the estimated linear models and by the semi-parametric analysis.Originality/valueA first element of originality of our study consists of investigating the macro determinants of occupation accidents at a regional Italian level. Second, the empirical literature (Boone and Van Ours, 2006) highlights the possible bias of underreporting behaviours on nonfatal accidents in contrast to fatal accidents that are always reported. From this perspective, we have identified a few analyses (namely, Boone et al., 2011) considering different accident sets characterised by different severity degrees. Thus, this paper contributes to the literature considering five alternative subsets of accidents stratified by degree of severity (i.e. moderate, severe, moderate plus severe, severe plus fatal and total accident rates) to test for possible underreporting bias affecting our econometric model.
Flexing to outperform: workforce differentiation, HR flexibility and firm performance
Authors: Apascaritei Paula , Elvira Marta M. , Rodríguez-García María 
Published: June 2024

PurposeResource orchestration theory proposes that firms need resources, capabilities, and horizontal and vertical alignment to achieve high performance. Thus, we investigate which combinations of horizontal fit of resources (commitment-based HR systems for managers and nonmanagers) and capabilities (HR flexibility) together with vertical fit with business strategy (innovation versus cost leadership strategies) relate to superior performance.Design/methodology/approachOur study is based on a sample of 113 Spanish firms from which we collected data on commitment-based HR systems for managers and nonmanagers, HR flexibility, business strategy and performance. We employ a fuzzy set qualitative comparative analysis (fsQCA) to analyze which configurations lead to firm performance.FindingsThe empirical analysis shows that both HR practices and policies (commitment-based HR systems) and HR capabilities (HR flexibility) need to be aligned for high performance. The path for performance is comprised of a combination of commitment-based HR systems for staff and HR flexibility and by the absence of an innovation strategy or commitment-based HR systems for managers, HR flexibility, and a cost leadership strategy. We also find four paths where performance relies on efficiently combining an innovation and cost leadership business strategy.Originality/valueOur findings make three key contributions to the literature. First, we help elucidate multicausal relationships inside the black box of the “HR–performance” relationship for firm performance. Second, we study the vertical fit with business strategy by considering innovation and cost leadership strategies. Third, we analyze multicausal pathways, thus uncovering different combinations of resources and capabilities for performance.
An examination of the needs and preferences for student housing in Germany in relation to different financial backgrounds using the example of the city of Aachen
Authors: von Wittenhorst zu Sonsfeld Lisa , Beusker Elisabeth 
Published: June 2024

PurposeThe aim of this paper is to determine the needs and preferences of students concerning different areas and attributes of dormitories, taking their financial background into account.Design/methodology/approachA quantitative survey was conducted in the 21 publicly funded dormitories in Aachen (Germany) in 2022 to determine students’ needs and preferences for housing. In total, more than 1,200 students participated in the 10-min online survey.FindingsThe findings show the needs and preferences of students from different financial backgrounds for various areas in the dormitory. These include the location of the dormitory, the outdoor area, the shared spaces, the sanitary facilities (bathroom and kitchen), and the students’ private rooms. The results are divided into needs that all students have regardless of their financial background (“must-haves”) and needs that correspond to individual financial groups (“nice-to-haves”).Research limitations/implicationsThe results relate to the medium-sized city of Aachen as a case study in Germany – with an average rent level – and its urban situation. The outcomes are therefore only transferable to a limited extent to cities with different framework conditions, as the needs and preferences of students may differ.Practical implicationsThe results serve as a valuable guideline for future development in the field of student housing for different rental segments.Originality/valueThe paper fills a research gap in the identification of current student housing needs and preferences in German dormitories, taking financial backgrounds into account.
Pandemic market dynamics: analyzing global price informativeness during COVID-19
Authors: Abdallah Abed Al-Nasser , Abdallah Wissam , Bassam Youssef , Rao Ullas , Saad Mohsen 
Published: June 2024

Purpose
This study aims to examine stock price synchronicity during the COVID-19 crisis using 32,452 firms from 61 countries. This paper explores the impact of government effectiveness on synchronicity while distinguishing between developed and emerging markets.

Design/methodology/approach
The research analysis employs ordinary OLS pooled regression analysis.

Findings
This paper presents worldwide evidence that stock price synchronicity was significantly higher during February and March 2020. This paper shows that synchronicity increased with the intensity of the crisis. In addition, the government's role reduced the COVID-19 impact on synchronicity, which was stronger in developed markets than in emerging markets.

Originality/value
The novelty of the study lies in documenting the impact of the COVID-19 pandemic on stock price synchronicity. The findings add to a deeper understanding of market behavior amid significant disruptive shocks.
You are what you wear: the effect of religiosity, self-esteem and materialism toward conspicuous consumption of luxury fashion products among Gen Z
Authors: Ananda Harris Rizki , Indraswari Kenny Devita , Azizon A. , Muzayanah Irfani Fithria Ummul , Arundina Tika , Damayati Ashintya 
Published: June 2024

Purpose
The market value of luxury goods at the global and national levels continues to increase from year to year. The sales growth of the Indonesian luxury goods market is currently at 6.6% per year. The largest sales sector in the market is the fashion sector, with more than US$700m per year. Several big cities in Asia, including Jakarta, experienced a shift in the age group of luxury goods buyers to a younger group with limited income resources. The behavior of purchasing luxury goods in the low-income group is contrary to Islamic values, which prioritize the fulfillment of needs rather than the fulfillment of desires. This study aims to analyze the factors that influence the intention of Muslim Generation Z consumers to buy luxury fashion products.

Design/methodology/approach
The purposive sampling method in this study involved 240 respondents who had bought luxury fashion products in the masstige category in the past two years. This study adopts the Theory of Reasoned Action (TRA) model and a quantitative approach through the structural equation modeling method.

Findings
The results of this study indicate that attitude towards behavior, subjective norms, self-esteem and materialism have a significant positive effect on the intention to consume luxury fashion, while the influence of religiosity was found to be insignificant. At the same time, religiosity has a significant negative effect on attitude towards behavior and subjective norms.

Research limitations/implications
These findings indicate that if consumers who have a positive attitude toward luxury fashion purchases, can be influenced by their significant others, self-esteem and materialistic nature, then they tend to buy luxury fashion items.

Originality/value
This study extends the theory of TRA by adding religiosity, self-esteem and materialism and it uses Muslim Generation Z as the respondent. Masstige category of luxury brands is also used to take into account the affordability of its generation toward luxury fashion products.