bluuebunny/crossref_metadata_2025_split huggingface dataset:
A High‐Throughput Screening Strategy for Synthesizing Molecularly Imprinted Polymer Nanoparticles Selectively Targeting Tumors
Authors: Song Qingmei , Li Yan , Ma Liang , Li Yuan , Lv Yongqin 
Published: July 2024

AbstractMolecularly imprinted polymers (MIPs) show significant promise as effective alternatives to antibodies in disease diagnosis and therapy. However, the challenging process of screening extensive libraries of monomer combinations and synthesis conditions to identify formulations with enhanced selectivity and affinity presents a notable time constraint. The need for expedient methods becomes clear in accelerating the strategic development of MIPs tailored for precise molecular recognition purposes. In this study, an innovative high‐throughput screening methodology designed to identify the optimal MIP formulation for targeting tumors is presented. Employing a microtiter plate format, over 100 polymer syntheses are conducted, incorporating diverse combinations of functional monomers. Evaluation of binding performance utilizes fluorescence‐based assays, focusing on an epitope of the epidermal growth factor receptor (EGFR). Through this meticulously structured screening process, synthesis conditions that produced MIP nanoparticles exhibiting substantial specificity for EGFR targeting (KD = 10−12 m) are identified. These “bionic antibodies” demonstrate selective recognition of cancer cells in whole blood samples, even at concentrations as low as 5 cells mL−1. Further validation through fluorescent imaging confirms the tumor‐specific localization of the MIPs in vivo. This highly efficient screening approach facilitates the strategic synthesis of imprinted polymers functioning as precision bioprobes.
Dual‐Engineered Macrophage‐Microbe Encapsulation for Metastasis Immunotherapy
Authors: Wu Leyang , Qiao Liyuan , Zhang Shuhui , Qiu Jiahui , Du Zengzheng , Sun Ying , Chang Xiaoyao , Li Lin , Li Chenyang , Qiao Xinyue , Yin Xingpeng , Hua Zichun 
Published: July 2024

AbstractLung metastases are the leading cause of death among cancer patients. The challenges of inefficient drug delivery, compounded by a robust immunosuppressive microenvironment, make effective treatment difficult. Here, an innovative dual‐engineered macrophage‐microbe encapsulation (Du‐EMME) therapy is developed that integrates modified macrophages and engineered antitumor bacteria. These engineered macrophages, termed R‐GEM cells, are designed to express RGD peptides on extracellular membranes, enhancing their tumor cell binding and intratumor enrichment. R‐GEM cells are cocultured with attenuated Salmonella typhimurium VNP20009, producing macrophage‐microbe encapsulation (R‐GEM/VNP cells). The intracellular bacteria maintain bioactivity for more than 24 h, and the bacteria released from R‐GEM/VNP cells within the tumor continue to exert bacteria‐mediated antitumor effects. This is further supported by macrophage‐based chemotaxis and camouflage, which enhance the intratumoral enrichment and biocompatibility of the bacteria. Additionally, R‐GEM cells loaded with IFNγ‐secreting strains (VNP‐IFNγ) form R‐GEM/VNP‐IFNγ cells. Treatment with these cells effectively halts lung metastatic tumor progression in three mouse models (breast cancer, melanoma, and colorectal cancer). R‐GEM/VNP‐IFNγ cells vigorously activate the tumor microenvironment, suppressing tumor‐promoting M2‐type macrophages, MDSCs, and Tregs, and enhancing tumor‐antagonizing M1‐type macrophages, mature DCs, and Teffs. Du‐EMME therapy offers a promising strategy for targeted and enhanced antitumor immunity in treating cancer metastases.
A Fast and Strong Microactuator Powered by Internal Combustion of Hydrogen and Oxygen
Authors: Uvarov Ilia V. , Shlepakov Pavel S. , Svetovoy Vitaly B. 
Published: July 2024

AbstractThe development of fast and strong microactuators that can be integrated in microdevices is an essential challenge due to a lack of appropriate driving principles. A membrane actuator powered by internal combustion of hydrogen and oxygen in a chamber with a volume of 3.1 nanoliters is demonstrated. The combustion in such a small volume is possible only for an extremely high surface‐to‐volume ratio on the order of 107 m−1. The fuel with this ratio is prepared electrochemically in a special regime that produces only nanobubbles. A cloud of nanobubbles merges, forming a microbubble, which explodes, increasing the volume 500× in 10 µs. The actuator generates an instantaneous force up to 0.5 N and is able to move bodies 11 000× more massive than itself. The natural response time of ≈10 ms is defined by the incubation time needed to produce an exploding bubble. The device demonstrates reliable cyclic actuation at a frequency of 1 Hz restricted by the effect of electrolyte aging. After 40 000 explosions, no significant wear in the chamber is observed. Due to a record‐breaking acceleration and standard microfabrication techniques, the actuator can be used as a universal engine for various microdevices including microelectromechanical systems, microfluidics, microrobotics, wearable and implantable devices.
Hydrodynamic Parameter Identification of Deep‐Sea Mining Vehicle during Deployment and Retrieval Using a Nonlinear Filter
Authors: Guan Yingjie , Qin Hongmao , Hu Manjiang , Cui Qingjia , Zheng Hao , Ding Rongjun 
Published: July 2024

AbstractThe aim of this paper is to propose a novel method for identifying the hydrodynamic parameters of a deep‐sea mining vehicle during deployment and retrieval. The proposed approach combines numerical simulation with a nonlinear filter. Initially, a dedicated hydrodynamic model for the deployment and retrieval of the mining vehicle is constructed. The identification process commences with simulations based on computational fluid dynamics (CFD). This approach utilizes CFD to simulate the motion of the deep‐sea mining vehicle during deployment and retrieval, employing an implicit solution approach to analyze its motion in Heave and Yaw degrees of freedom under periodic external forces. Consequently, this provides hydrodynamic performance data. Subsequently, the unscented Kalman filter (UKF) estimator is applied to optimally solve an augmented matrix that incorporates both motion data and hydrodynamic parameters, yielding numerical values for the hydrodynamic parameters. Simulation results demonstrate that, in comparison to motion performance obtained by the CFD method, the hydrodynamic model derived from UKF enables an effective prediction of the motion of the deep‐sea mining vehicle, with prediction errors consistently below 6%.
Ultrafast Laser Manipulation of In‐Lattice Plasmonic Nanoparticles
Authors: Zhu Han , Chu Lingrui , Lv Hengyue , Ye Qingchuan , Juodkazis Saulius , Chen Feng 
Published: July 2024

AbstractPlasmonic nanoparticles enable manipulation and enhancement of light fields at deep subwavelength scales, leading to structures and devices for diverse applications in optics. Despite hybrid plasmonic materials display remarkable optical properties due to interactions between components in nanoproximity, scalable production of plasmonic nanostructures within a single‐crystalline matrix to achieve an ideal plasmon–crystal interface remains challenging. Here, a novel approach is presented to realize efficient manipulation of in‐lattice plasmonic nanoparticles. Employing ultrafast‐laser‐driven plasmonic nanolithography, metallic nanoparticles with controllable morphology are precisely defined in the crystalline lattice of yttrium aluminum garnet (YAG) crystal. Through direct ion implantation, hybrid plasmonic material composed of nanoparticles embedded in a sub‐surface amorphous YAG layer is created. Subsequently, femtosecond laser pulses guide formation and reshaping of plasmonic nanoparticles from the amorphous layer into the single‐crystalline matrix along direction of light propagation, facilitated by a plasmon‐mediated evolution of laser energy deposition. By tailoring resonance modes and optimizing the coupling between structured particle assemblies, a range of applications including polarization‐dependent absorption and nonlinearity, controllable photoluminescence, and structural color generation is demonstrated. This research introduces a new approach for fabricating advanced optical materials featuring in‐lattice plasmonic nanostructures, paving the way for the development of diverse functional photonic devices.
Effect of wind speed and net radiation on the oasis effect in temperate rice paddy fields
Authors: Kim Hyunki , Kim Bo‐Kyeong , Moon Hyun‐Dong , Shin Seo‐Ho , Lee Hyeong Ju , Ha Jong‐Sung , Jeong Seungtaek , Yeom Jong‐Min , Kim Yoon Hyung , Cho Jaeil 
Published: July 2024

AbstractThe oasis effect, characterized by atmospheric cooling due to excessive evapotranspiration (ET) and the inflow of warm air from the surroundings, has been well documented in vegetated oases. Despite its significant ET rates, the atmospheric cooling phenomenon in rice paddies has not received extensive exploration. This study investigates the oasis effect during July and August, the peak months for ET in rice fields in temperate climate. Over 3 years (2020–2022), energy flux observations using the eddy covariance method were conducted to analyze atmospheric cooling in paddy fields. The findings revealed a pronounced atmospheric cooling effect associated with negative sensible heat in paddy fields. Moreover, this cooling phenomenon exhibited heightened activity during periods of increased wind speeds (>3.5 m/s) and subdued net radiation (<400 W/m2). These results highlight rice paddies' potential to cool the atmosphere, acting as a countermeasure against global warming and the urban heat island effect.
Epitaxial Single‐Crystalline PZT Thin Films on ZrO2‐Buffered Si Wafers Fabricated Using Spin‐Coating for Mass‐Produced Memristor Devices
Authors: Li Haining , Kijima Takeshi , Yamahara Hiroyasu , Tabata Hitoshi , Seki Munetoshi 
Published: July 2024

AbstractA Pb(Zr0.52Ti0.48)O3 (PZT) thin film is fabricated on SrRuO3(SRO)/Pt/ZrO2/Si, and its resistive switching properties are thoroughly investigated. The ZrO2 thin film serves as a buffer layer for the epitaxial growth of single‐crystalline PZT thin films, and spin‐coating fabrication is useful for introducing a suitable defect content to achieve effective resistive switching in PZT. The present PZT thin film exhibits improved ferroelectric properties compared with most of the spin‐coated or sol‐gel prepared PZT films reported previously, with a large saturation polarization of ≈43 µC cm−2 and coercive filed of ≈700 kV cm−1. The symmetrically reversed true‐remanent hysteresis shows no evident imprint effect and a fully saturated polarization is observed. Intrinsic ferroelectric properties indicate the presence of non‐switching components that are conducive to memory applications. Butterfly shaped electrical conduction reveals resistive switching behavior, with abnormal bipolar resistive switching (BRS) at low voltages and normal BRS at high voltages. The abnormal BRS is explained by a microscopic mechanism involving ferroelectric polarization and an induced dipole moment, whereas the normal BRS is studied by fitting different conducting models and is dominated by interfacial barriers and defects. This study presents a progressive strategy for the large‐scale production of ferroelectric perovskite thin films, specifically suitable for silicon‐based memristors.
China's meat sector growth and U.S. grain and oilseed exports
Authors: Dhoubhadel Sunil P. , Ridley William 
Published: July 2024

AbstractGiven China's role as a dominant grain and oilseeds importer, any changes in Chinese policy can significantly affect exporting countries. We estimate how the domestic supply and demand factors determine China's grain and oilseed imports and project the impact on U.S. exports to China with changes in Chinese policies. The results indicate that China's policy on increasing domestic soybeans and corn production and decreasing meat consumption can considerably diminish the U.S. and its competitors' exports to China. The key policy implication is that the United States should actively seek out new export markets considering China's evolving supply and demand conditions.
Wheat cover crop has minimal effect on physical soil properties in the North Carolina Piedmont
Authors: Roper Wayne R. , Osmond Deanna L. , Heitman Joshua L. 
Published: July 2024

AbstractEnvironmental awareness about soil and water conservation in agroecosystems has shifted behaviors toward favoring conservation practices in agricultural management. Interest in conservation tillage and cover cropping has increased, but some regions encounter major challenges with adjusting management to accommodate these practices while optimizing crop production. In an Ultisol in the North Carolina Piedmont, a long‐term corn (Zea mays) and soybean (Glycine max) rotation with tillage intensities ranging from no‐till to moldboard plowing in a randomized complete block design was used to assess changes in physical soil properties after introducing wheat (Triticum aestivum) as a winter cover crop. Cover crop biomass was measured along with volumetric water content (VWC) and bulk density (BD) at 0–15 cm, water retention (WR), water‐stable aggregation (WSA), and soil organic carbon (SOC) at 0–7.5 cm, and penetration resistance (PR) at 0–45 cm. No differences in VWC or WR could be solely attributed to cover cropping, but no‐till with cover cropping had the highest macroporosity where there was no vehicle traffic. Vehicle traffic had a stronger effect on soil compaction (BD and PR) than cover cropping regardless of tillage. Conservation tillage increased WSA and SOC when compared to plow tillage, but three seasons of a wheat cover crop did not significantly change these properties, possibly because wheat produced low biomass each year (750–1900 kg ha−1). Wheat had minimal effect on physical soil properties in the short term, and potential for improvement with long‐term optimal cover crop management in this region requires further assessment.
Risk of myeloproliferative neoplasms among U.S. Veterans from Korean, Vietnam, and Persian Gulf War eras
Authors: Tiu Andrew , McKinnell Zoe , Liu Shanshan , Gill Puneet , Antonio Martha , Shancer Zoe , Srinivasa Nandan , Diao Guoqing , Subrahmanyam Ramesh , Kessler Craig M. , Jain Maneesh 
Published: July 2024

AbstractThe Promise to Address Comprehensive Toxics (PACT) Act expanded U.S. Veterans' health care and benefits for conditions linked to service‐connected exposures (e.g., Burn Pits, Agent Orange). However, myeloproliferative neoplasms (MPN) are not recognized as presumptive conditions for Veterans exposed to these toxic substances. This study evaluated the development of MPN among U.S. Veterans from the Korean, Vietnam, and Persian Gulf War eras. This retrospective cohort study included 65 425 Korean War era Veterans; 211 927 Vietnam War era Veterans; and 214 007 Persian Gulf War era Veterans from January 1, 2006, to January 26, 2023. Veterans with MPN, thrombosis, bleeding, and cardiovascular risk factors were identified through ICD‐9 and ‐10 codes. Veterans from the Persian Gulf War era had the highest risk of developing MPN compared with Veterans from the Korean and Vietnam War eras, hazard ratio (HR) 4.92, 95% confidence interval (CI) 4.20–5.75 and HR 2.49, 95% CI 2.20–2.82, both p < .0001, respectively. Vietnam War era Veterans also had a higher risk of MPN development compared with Korean War era Veterans, HR 1.97, 95% CI 1.77–2.21, p < .0001. Persian Gulf War era Veterans were diagnosed with MPN at an earlier age, had higher risks of thrombosis and bleeding, and had lower survival rates compared with Korean War and Vietnam War era Veterans. This study reinforces evidence that environmental and occupational hazards increase the risk of clonal myeloid disorders and related complications, impacting overall survival with MPN. Limitations include the inability to confirm clonality and fully verify deployment and exposure status.
Helicene Covalent Organic Frameworks for Robust Light Harvesting and Efficient Energy Transfers
Authors: Yin Cong , Ye Xingyao , Tao Shanshan , Zhao Dan , Zhi Yongfeng , Jiang Donglin 
Published: July 2024

AbstractHelicenes represent a class of fascinating π compounds with fused yet folded backbones. Despite their broad structural diversity, harnessing helicenes to develop well‐defined materials is still a formidable challenge. Here we report the synthesis of crystalline porous helicene materials by exploring helicenes to synthesize covalent 2D lattices and layered π frameworks. Topology‐directed polymerization of [6]helicenes and porphyrin creates 2D covalent networks with alternate helicene‐porphyrin alignment along the x and y directions at a 1.5‐nm interval and develops [6]helicene frameworks through reversed anti‐AA stack along the z direction to form segregated [6]helicene and porphyrin columnar π arrays. Notably, this π configuration enables the frameworks to be highly red luminescent with benchmark quantum yields. The [6]helicene frameworks trigger effieicnt intra‐framework singlet‐to‐singlet state energy transfer from [6]helicene to porphyrin and facilitate intermolecular triplet‐to‐triplet state energy transfer from frameworks to molecular oxygen to produce reactive oxygen species, harvesting a wide range of photons from ultraviolet to near‐infrared regions for light emitting and photo‐to‐chemical conversion. This study introduces a new family of extended frameworks, laying the groundwork for exploring well‐defined helicene materials with unprecedented structures and functions.
BIM‐basierte Evaluierung nachhaltiger Instandhaltungsmaßnahmen für bestehende Gebäudestrukturen
Authors: Jäkel Jan‐Iwo , Morgenstern Hendrik , Kloesgen Linus , König Timothy , Klemt‐Albert Katharina , Raupach Michael 
Published: July 2024

AbstractIn Deutschland werden rd. 70 % aller Bauleistungen im Bereich des Hochbaus an bestehenden Gebäuden erbracht. Dieser hohe Anteil unterstreicht die Notwendigkeit eines ressourceneffizienten Instandhaltungsmanagements von Gebäuden. Dafür erfolgt die Verknüpfung von digitalen Methoden und Technologien unter Integration von Nachhaltigkeitsaspekten für die optimierte Entscheidungsfindung. In diesem Aufsatz wird eine ganzheitliche Methode zur Gebäudeinstandhaltung durch den Einsatz der BIM‐Methode in Kombination mit der Integration von Nachhaltigkeitsaspekten entwickelt. Dabei werden innerhalb eines teilautomatisierten Workflows verschiedene digitale Technologien miteinander kombiniert. Im ersten Schritt wird in einer Literaturrecherche der Status quo der BIM‐basierten Instandhaltung an Stahlbetonbauwerken sowie der Nachhaltigkeitsanalyse von Gebäuden analysiert. Folgend werden die prozessualen und datentechnischen Grundlagen definiert. Darauf aufbauend erfolgt die Konzeptentwicklung und Validierung unter Abhaltung der Schritte Datenerfassung, algorithmische Datenverarbeitung und Nachhaltigkeitsanalyse sowie Datenbereitstellung über Augmented Reality und Common Data Environment. Schließlich werden die Prozessschritte anhand eines realen Demonstrators validiert. Das Ergebnis des Beitrags zeigt eine teilautomatisierte Prozesskette und Entscheidungsunterstützung für ein ressourceneffizientes Instandhaltungsmanagement von Stahlbetonbauwerken.
A reflection on the voluntary disclosure of sustainable development goals: The role of sustainability committee
Authors: Hamad Salaheldin , Lai Fong‐Woon , Shad Muhammad Kashif , Shah Syed Quaid Ali , Jan Ahmad Ali , Ali Syed Emad Azhar 
Published: July 2024

AbstractLimited research explores the private sector's role in achieving Sustainable Development Goals (SDGs), particularly regarding factors influencing disclosure practices in emerging economies. This study addresses this gap by investigating the voluntary disclosure of SDGs and the impact of the sustainability committee (SC) on such disclosure in Malaysia. Panel data from large publicly listed Malaysian companies spanning from 2016 to 2020 is employed. Manual content analysis extracts the SDGs‐related information from the annual reports. Data were analyzed using univariate and multivariate analytical models to examine the effect of the sustainability committee's existence on the SDGs disclosure. Findings reveal an increasing trend in Malaysian companies' commitment to SDGs, with a stronger emphasis on social goals compared to environmental ones. The results of the T‐test, fixed effects, and two‐stage least squares regressions demonstrate significantly higher and more detailed SDG disclosure in companies with SCs compared to those without SCs. These findings suggest that SCs facilitate the integration of SDGs into corporate strategies and business models. Sensitivity analyses have not altered our findings. This research provides useful insights for policymakers and practitioners regarding corporate SDGs disclosure practices and the role of sustainability committees in enhancing such practices.
Strategic integration of environmental sustainability in inland logistics: A multi‐criteria decision‐making approach
Authors: Charłampowicz Jędrzej , Mańkowski Cezary , Saikouk Tarik 
Published: July 2024

AbstractThis study develops a reference model for managing inland logistics operations with a focus on environmental sustainability. As global supply chains face the imperative of integrating environmental practices, inland logistics operators are pivotal in this transition. Utilizing fuzzy‐DEMATEL analysis, the research identifies key management concepts and their interrelationships, highlighting strategic and operational management as the most significant. The approach distinguishes between causal and effectual concepts, prioritizing actions and resources for a dynamic management system.Actionable strategies derived from the findings prompt inland logistics operators to focus on process management as a primary tool for implementing strategic objectives. The model suggests that environmental management, while critical, is not perceived as a priority in Polish inland transport, indicating a potential area for further development. The study's practical implications underscore the need for logistics operators to integrate this reference model, enhancing operational efficiency and addressing environmental standards.Theoretically, the research enriches logistics management literature by offering a robust framework that operationalizes management concepts within inland logistics. By advancing the methodological application of fuzzy‐DEMATEL, the study provides a new lens for examining management dynamics. The reference model's emphasis on environmental sustainability contributes to the theoretical understanding of sustainable logistics practices.In sum, the research offers a comprehensive framework for inland logistics operators, balancing environmental sustainability with operational efficiency. It serves as a guide for future research and practical application, setting a new direction for sustainable logistics management.