bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Bump Statistic on Permutations Resulting from the Robinson–Schensted Correspondence
Authors: Dukes Mark , Mullins Andrew 
Published: July 2024

AbstractIn this paper, we investigate a permutation statistic that was independently introduced by Romik (Funct Anal Appl 39(2):52–155, 2005). This statistic counts the number of bumps that occur during the execution of the Robinson–Schensted procedure when applied to a given permutation. We provide several interpretations of this bump statistic that include the tableaux shape and also as an extremal problem concerning permutations and increasing subsequences. Several aspects of this bump statistic are investigated from both structural and enumerative viewpoints.
Kardiale Kanalopathien im Kontext hereditärer Arrhythmiesyndrome
Authors: Huttelmaier Moritz T. , Fischer Thomas H. 
Published: July 2024

ZusammenfassungHereditäre Arrhythmiesyndrome sind seltene Erkrankungen, die allerdings im Kindes‑, Jugend- und jungen Erwachsenenalter eine häufige Ursache des plötzlichen Herztods darstellen. Grundsätzlich kann im Kontext genetischer Erkrankungen eine Unterscheidung zwischen Kanalopathien und Kardiomyopathien getroffen werden. Schwerpunkt der vorliegenden Arbeit sind die Kanalopathien Long- und Short-QT-Syndrom, Brugada-Syndrom sowie die katecholaminerge polymorphe ventrikuläre Tachykardie (CPVT). Eine frühzeitige Diagnose dieser Erkrankungen ist unerlässlich, lassen sich doch durch die medikamentöse Therapie, die Aufklärung über Verhaltensmaßnahmen und gegebenenfalls die Implantation eines Kardioverter-Defibrillators die Prognose und Lebensqualität der Patienten signifikant verbessern. Der Beitrag beleuchtet die pathophysiologischen und genetischen Grundlagen dieser Kanalopathien, beschreibt deren klinische Manifestation und kommentiert die Grundlagen für Diagnose, Risikostratifikation und Therapie.
Shadowgraph tomography of a high-pressure GDI spray
Authors: Lazzaro Maurizio , Alfuso Salvatore , Ianniello Roberto 
Published: July 2024

AbstractAn isooctane spray from a high-pressure multihole GDI injector (Bosch HDEV6) was characterised by means of optical extinction tomography, relying on collimated illumination by a focused shadowgraph setup. The tests were carried out in air under ambient conditions at an injection pressure of 300 bar. Spray images were acquired over a 180-degree angular range in 1-degree increments. The critical issues of optical extinction tomography of sprays, related to the strong light extinction by the dense liquid core of fuel jets, were addressed. To mitigate artefacts arising from the reconstruction process, the extinction data were subjected to spatially-variant filtering steps for both raw and post-log data before being analytically inverted through the inverse Radon transform. This approach made it possible to process extinction data at very large optical depths. A nearly complete three-dimensional reconstruction of the spray was obtained, providing significant details of the spray morphology and the internal structure of the jets throughout spray development. Different phases of the atomization process, from the near-field to the far-field regions of the spray, were observed.
Silencing of ultradian rhythms and metabolic depression during spontaneous daily torpor in Djungarian hamsters
Authors: Heldmaier Gerhard , Braulke Luzie , Flick Johanna , Ruf Thomas 
Published: July 2024

AbstractUltradian rhythms of metabolism, body temperature and activity are attenuated or disappear completely during torpor in Djungarian hamsters, for all three ultradian periodicities (URsmall, URmedium and URlarge). URsmall and URmedium disappear during entrance into torpor, whereas URlarge disappear later or continue with a low amplitude. This suggests a tight functional link between torpor and the expression of ultradian rhythms, i.e. torpor is achieved by suppression of metabolic rate as well as silencing of ultradian rhythms. Spontaneous torpor is often initiated after an ultradian burst of activity and metabolic rate, beginning with a period of motionless rest and accompanied by a decrease of metabolic rate and body temperature. To extend previous findings on the potential role of the adrenergic system on torpor induction we analysed the influence of the ß3-adrenergic agonist Mirabegron on torpor in Djungarian hamsters, as compared to the influence of the ß-adrenergic antagonist Propranolol. Hamsters were implanted with 10 day release pellets of Mirabegron (0.06 mg day−1) or Propranolol (0.3 mg day−1). Mirabegron transiently supressed and accelerated ultradian rhythms but had no effect on torpor behaviour. Propranolol did not affect torpor behaviour nor the expression of ultradian rhythms with the dosage applied during this study.
HIV-associated rectovaginal fistulae in children: a single-centre retrospective study in the antiretroviral era
Authors: Alberti Piero , Westgarth-Taylor Christopher , Trovalusci Emanuele , Charlton Robyn , Brisighelli Giulia 
Published: July 2024

Abstract
Purpose
Acquired rectovaginal fistulae (RVF) are a complication of paediatric HIV infection. We report our experience with the surgical management of this condition.

Methods
We retrospectively reviewed the records of paediatric patients with HIV-associated RVF managed at Chris Hani Baragwanath Academic Hospital (2011–2023). Information about HIV management, surgical history, and long-term outcomes was collected.

Results
Ten patients with HIV-associated RVF were identified. Median age of presentation was 2 years (IQR: 1–3 years). Nine patients (9/10) underwent diverting colostomy, while one demised before the stoma was fashioned. Fistula repair was performed a median of 17 months (IQR: 7.5–55 months) after colostomy. An ischiorectal fat pad was interposed in 5/9 patients. Four (4/9) patients had fistula recurrence, 2/9 patients developed anal stenosis, and 3/9 perineal sepsis. Stoma reversal was performed a median of 16 months (IQR: 3–25 months) after repair. Seven patients (7/9) have good outcomes without soiling, while 2/9 have long-term stomas. Failure to maintain viral suppression after repair was significantly associated with fistula recurrence and complications (φ = 0.8, p < 0.05).

Conclusion
While HIV-associated RVFs remain a challenging condition, successful surgical treatment is possible. Viral suppression is a necessary condition for good outcomes.
Therapeutic management of peritonsillar abscess during COVID-19
Authors: Cidlinsky Natascha , Arndt Tim Tobias , Schiele Stefan , Thölken Rubens , Treutlein Eric , Müller Gernot , Zenk Johannes , Doescher Johannes 
Published: July 2024

Abstract
Purpose
The purpose of this study is to examine the effects of the Covid-19 pandemic and lockdown policies in Germany on frequency and treatment of peritonsillar abscess at a tertiary referral center in Germany.

Methods
This retrospective case-control study analyzed all cases of peritonsillar abscess treated from 03/01/2018 until 08/30/2022 at Augsburg ENT University Hospital, Germany, through abscess tonsillectomy and/ or incisional drainage. Data was collected and correlated to Covid-19 Stringency Index using codes based on the Institute for Hospital Remuneration System in Germany. After excluding 303 cases, 975 abscess tonsillectomy and incisional drainage cases were studied, with the first German lockdown serving as cutoff date. Treatment algorithm was maintained regardless of co-infection with Covid-19.

Results
A total of 174 patients received abscess tonsillectomy as therapy, while 801 patients underwent incisional drainage. Before the first German lockdown, 452 patients received incisional drainage. Since the pandemic, 349 cases of incisional drainage were registered (OR = 0.54, 95%-CI [0.27–0.86], p = 0.04), despite no significant change in the percentage of peritonsillar abscess of all ENT emergencies. The mean age at presentation with PTA was 39.8 years, and the rate of relapse was 4.0%. The study found no association between the scale of policy measures and treatment (OR = 1.00, 95%-CI [0.99–1.01], p = 0.52).

Conclusion
The results indicate that, despite the reduction in capacities due to Covid-19, the proportion of patients with peritonsillar abscess treated through abscess tonsillectomy increased at Augsburg ENT University Hospital since the first German lockdown. Hospitalization times could still be reduced with comparable relapse rates.
Evaluation of peripheral blood inflammatory biomarkers in sickle cell disease with and without retinopathy
Authors: Özer Ömer , Doğan Levent , Baysal Zeki , Basir Hakan , Çıftçı Ali Türker , Eröz Pınar , Güçlü Emin Serbülent 
Published: July 2024

Abstract
Background
The aim of this study was to evaluate the clinical significance of blood-cell associated inflammation markers in patients with sickle cell disease (SCD) and sickle cell retinopathy (SCR).

Methods
Neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), monocyte to lymphocyte ratio (MLR), systemic immune inflammation index (SIII), systemic inflammation response index (SIRI), systemic inflammation modulation index (SIMI) and aggregate systemic inflammation index (AISI) were calculated. This study included 45 healthy controls (Group 1) and 100 SCD (Group 2). Patients in Group 2 were then divided into two groups: without SCR (Group 3) and with SCR (Group 4), and patients with SCR (Group 4) were further divided into two groups: non-proliferative sickle cell retinopathy (NPSCR) (Group 5) and proliferative sickle cell retinopathy (PSCR) (Group 6).

Results
The mean values for NLR, PLR, SIII, SIRI, AISI, and SIMI were significantly higher in Group 2 compared to Group 1 (p = 0.011 for NLR, p = 0.004 for SIII, and p < 0.001 for others). Furthermore, AISI and SIMI parameters demonstrated statistically significant discriminatory power to distinguish Group 5 from Group 6 (p = 0.0016 and p = 0.0006, respectively).

Conclusion
Given the critical role of inflammatory mechanisms in the pathogenesis of SCD and its related complications, the assessment of blood-cell-associated inflammatory markers may present a pragmatic and advantageous approach to the clinical oversight and therapeutic intervention of SCD.
Similar genetic profile in early and late stage urothelial tract cancer
Authors: Stormoen Dag Rune , Rohrberg Kristoffer Staal , Mouw Kent William , Ørum Katrine , Szallasi Zoltan , Rossing Maria , Bagger Frederik Otzen , Pappot Helle 
Published: July 2024

Abstract
Introduction
Urothelial tract cancer (UTC) ranks as the tenth most prevalent cancer and holds the seventh position in terms of mortality worldwide. Despite its prevalence and mortality ranking, there are still gaps in the knowledge of the mutational landscape in patients with advanced disease who have limited therapeutic options after multiple lines of prior treatment. This study compares the genomic and transcriptomic landscape, and targeted treatment options between metastatic UTC (mUTC) patients treated with multiple lines of therapy compared to newly diagnosed, untreated Muscle Invasive Bladder Cancer (MIBC).

Methods
We compared genomic and clinical data from two cohorts: mUTC patients who received multiple lines of therapy and were referred to the Copenhagen Prospective Personalized Oncology (CoPPO) project at Rigshospitalet, University of Copenhagen. Data for MIBC UTC patients were acquired from the Cancer Genome Atlas Bladder Cancer (TCGA BLCA) cohort. Biopsies in CoPPO were performed at the time of enrollment. 523 highly important cancer-related genes (TrueSight Oncology-500 targeted sequencing panel) were used from both cohorts for comparative analysis. Analyses included RNA count data to compare predicted molecular subtypes in each cohort separately.

Results
Patients from the CoPPO cohort had a lower median age at first-line treatment than the TCGA BLCA cohort, with no significant gender disparity. The predominant histology was urothelial cell carcinoma in both cohorts. Genomic analysis revealed no significant difference between the top mutated genes in the two cohorts, specifically looking into DNA damage repair genes. Molecular subtyping indicated a higher frequency of neuroendocrine differentiation in the CoPPO cohort. 13% of patients in the CoPPO cohort received targeted therapy based on genomic findings, and 16% received non-targeted treatment, totaling 29% receiving CoPPO treatment (9 patients). The remaining 71% received best supportive care. Kaplan-Meier analysis showed a non-significant survival benefit for the intervention group in the CoPPO cohort.

Conclusion
When focusing on 523 highly relevant cancer genes, the mutational profile of mUTC patients who have undergone numerous treatment lines resembles that of newly diagnosed MIBC. These alterations can be targeted, indicating the potential advantage of early genomic testing for personalized treatment within clinical trials.
Robotic liver parenchymal transection using the SynchroSeal
Authors: Pilz da Cunha Gabriela , De Meyere Celine , D’Hondt Mathieu , Swijnenburg Rutger-Jan 
Published: July 2024

Abstract
Background
There is much heterogeneity in the instrumentation used for parenchymal transection in minimally invasive liver surgery. Instruments specifically designed for robotic parenchymal transection of the liver are lacking. We aim to gain insight into the safety and effectiveness of the SynchroSeal (Intuitive Surgical, Inc., Sunnyvale, CA), a novel bipolar electrosurgical device, in the context of liver surgery.

Methods
The present study is a post-hoc analysis of prospectively collected data from patients undergoing robotic liver resection (RLR) using the SynchroSeal in two high-volume centres. The results of the SynchroSeal were compared with that of the previous generation bipolar-sealer; Vessel Sealer Extend (Intuitive Surgical, Inc., Sunnyvale, CA) using propensity score matching, after excluding the first 25 Vessel Sealer procedures per center.

Results
During the study period (February 2020–March 2023), 155 RLRs meeting the eligibility criteria were performed with the SynchroSeal (after implementation in June 2021) and 145 RLRs with the Vessel Sealer. Excellent outcomes were achieved when performing parenchymal transection with the SynchroSeal; low conversion rate (n = 1, 0.6%), small amounts of intraoperative blood loss (median 40 mL [IQR 10–100]), short hospital stays (median 3 days [IQR 2–4]), and adequate overall morbidity (19.4%) as well as severe morbidity (11.0%). In a matched comparison (n = 94 vs n = 94), the SynchroSeal was associated with less intraoperative blood loss (48 mL [IQR 10–143] vs 95 mL [IQR 30–200], p = 0.032) compared to the Vessel Sealer. Other perioperative outcomes were similar between the devices.

Conclusion
The SynchroSeal is a safe and effective device for robotic liver parenchymal transection.
Smoothed semicovariance estimation for portfolio selection
Authors: Ferrari Davide , Paterlini Sandra , Rigamonti Andrea , Weissensteiner Alex 
Published: July 2024

AbstractDownside risk measures, such as semivariance, are essential for evaluating investment risk. Focusing on semivariance allows investors to emphasize loss mitigation without considering upside volatility as risk. However, minimizing the semivariance of a portfolio is an analytically intractable and numerically challenging problem due to the endogeneity of the parameters in the semicovariance matrix. We introduce a methodology for consistent estimation of the portfolio semivariance based on a smooth approximation of the empirical semicovariance matrix. Differently from existing methods, the new estimator does not rely on biased surrogate semicovariance models and enables the treatment of large problems with many assets. The extent of smoothing is determined by a single tuning constant, which allows our method to span an entire set of optimal portfolios with limit cases represented by the minimum semivariance and the minimum variance portfolios. The methodology is implemented through an iteratively reweighted algorithm, which is computationally efficient for high-dimensional problems with many assets. Our numerical studies confirm the theoretical convergence of the smoothed semivariance estimator to the traditional sample semivariance. The resulting minimum smoothed semivariance portfolio performs well in- and out-of-sample compared to other popular selection rules.
Hypoglycemia and Alzheimer Disease Risk: The Possible Role of Dasiglucagon
Authors: Ali Naif H. , Al-Kuraishy Hayder M. , Al-Gareeb Ali I. , Hadi Najah R. , Assiri Abdullah A. , Alrouji Mohammed , Welson Nermeen N. , Alexiou Athanasios , Papadakis Marios , Batiha Gaber El-Saber 
Published: July 2024

AbstractAlzheimer's disease (AD) is a progressive neurodegenerative disease characterized by memory impairment and cognitive dysfunctions. It has been shown that hypoglycemia can adversely affect AD neuropathology. It is well-known that chronic hyperglycemia in type 2 diabetes (T2D) is regarded as a potential risk factor for the development and progression of AD. However, the effect of recurrent hypoglycemia on the pathogenesis of AD was not deeply discussed, and how recurrent hypoglycemia affects AD at cellular and molecular levels was not intensely interpreted by the previous studies. The underlying mechanisms for hypoglycaemia-induced AD are diverse such as endothelial dysfunction, thrombosis, and neuronal injury that causing tau protein hyperphosphorylation and the accumulation of amyloid beta (Aβ) in the brain neurons. Of note, the glucagon hormone, which controls blood glucose, can also regulate the cognitive functions. Glucagon increases blood glucose by antagonizing the metabolic effect of insulin. Therefore, glucagon, through attenuation of hypoglycemia, may prevent AD neuropathology. Glucagon/GLP-1 has been shown to promote synaptogenesis, hippocampal synaptic plasticity, and learning and memory, while attenuating amyloid and tau pathologies. Therefore, activation of glucagon receptors in the brain may reduce AD neuropathology. A recent glucagon receptor agonist dasiglucagon which used in the management of hypoglycemia may be effective in preventing hypoglycemia and AD neuropathology. This review aims to discuss the potential role of dasiglucagon in treating hypoglycemia in AD, and how this drug reduce AD neuropathology.
Effects of Physiological Status and Environmental Factors on the Lure Responses of Three Pest Fruit Fly Species (Diptera: Tephritidae)
Authors: Pogue Tania , Malod Kevin , Weldon Christopher W. 
Published: July 2024

AbstractBiotic and abiotic factors influence how insects respond to stimuli. This can make it challenging to interpret captures in traps used to monitor pest abundance in management programmes. To address this, the lure response of three pest fruit flies (Diptera: Tephritidae) was evaluated in a semi-field setting with respect to several physiological and environmental factors. Using standardised methods with known fly numbers in field cages, the response to Biolure (food-based lure) was evaluated for Ceratitis capitata, Ceratitis cosyra and Bactrocera dorsalis. Response to the male lures was tested: E.G.O PheroLure for C. capitata and C. cosyra, Trimedlure for C. capitata, and methyl eugenol for B. dorsalis. The physiological variables evaluated were fly age, sex, weight, and total body nutritional composition. The environmental effects of temperature, relative humidity and light intensity were also assessed. Protein-deprived adults responded more strongly to Biolure. The response to Biolure was not sex-specific. Fly age influenced the response of all species to all tested lures. However, this effect was species and lure specific. Temperature was the most influential environmental factor, with response generally increasing with temperature. Lower thresholds for lure response, despite the proximity of responsive flies, range from 12.21 to 22.95 °C depending on the species and lure tested. These results indicate that trapping systems and management activity thresholds must take physiological and environmental variation into account to increase their accuracy.
A quantitative modeling framework to understand the physiology of the hypothalamic-pituitary-adrenal axis and interaction with cortisol replacement therapy
Authors: Bindellini Davide , Michelet Robin , Aulin Linda B. S. , Melin Johanna , Neumann Uta , Blankenstein Oliver , Huisinga Wilhelm , Whitaker Martin J. , Ross Richard , Kloft Charlotte 
Published: July 2024

AbstractCongenital adrenal hyperplasia (CAH) is characterized by impaired adrenal cortisol production. Hydrocortisone (synthetic cortisol) is the drug-of-choice for cortisol replacement therapy, aiming to mimic physiological cortisol circadian rhythm. The hypothalamic-pituitary-adrenal (HPA) axis controls cortisol production through the pituitary adrenocorticotropic hormone (ACTH) and feedback mechanisms. The aim of this study was to quantify key mechanisms involved in the HPA axis activity regulation and their interaction with hydrocortisone therapy. Data from 30 healthy volunteers was leveraged: Endogenous ACTH and cortisol concentrations without any intervention as well as cortisol concentrations measured after dexamethasone suppression and single dose administration of (i) 0.5–10 mg hydrocortisone as granules, (ii) 20 mg hydrocortisone as granules and intravenous bolus. A stepwise model development workflow was used: A newly developed model for endogenous ACTH and cortisol was merged with a refined hydrocortisone pharmacokinetic model. The joint model was used to simulate ACTH and cortisol trajectories in CAH patients with varying degrees of enzyme deficiency, with or without hydrocortisone administration, and healthy individuals. Time-dependent ACTH-driven endogenous cortisol production and cortisol-mediated feedback inhibition of ACTH secretion processes were quantified and implemented in the model. Comparison of simulated ACTH and cortisol trajectories between CAH patients and healthy individuals showed the importance of administering hydrocortisone before morning ACTH secretion peak time to suppress ACTH overproduction observed in untreated CAH patients. The developed framework allowed to gain insights on the physiological mechanisms of the HPA axis regulation, its perturbations in CAH and interaction with hydrocortisone administration, paving the way towards cortisol replacement therapy optimization.
Graphical Abstract
Evaluating a School-Based Intervention on Adolescents’ Ethnic-racial Identity in Sweden
Authors: Abdullahi Amina K. , Syed Moin , Juang Linda P. , Berne Sofia , Hwang C. Philip , Frisén Ann 
Published: July 2024

AbstractFinding developmentally appropriate ways to support youth in understanding their own ethnic-racial identity is needed, particularly in contexts like Sweden where such support is not the norm. This preregistered longitudinal study examined whether an 8-week school-based intervention, the Identity Project, impacted youth ethnic-racial identity exploration (participation and search), resolution, private regard, and centrality. Participants were 509 adolescents in the 10th grade (Mage = 16.28, SD = 0.80; 65% self-identified girls; 52% minoritized ethnic background), who were randomized into an intervention or wait-list control group and assessed at baseline and three times post-intervention. The findings indicated an initial and simultaneous effect of the intervention only for exploration participation and resolution but did not show the expected chain of effects with earlier exploration predicting later resolution. Growth models indicated a greater increase in exploration participation over time for the intervention group than the control group. The findings indicate a mixed picture about the effectiveness of the intervention, with effects primarily narrowly targeted to exploration participation, but nevertheless highlight the potential for supporting Swedish youth in engaging with their ethnic-racial identities.