bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Novel Serum Metabolomics-Based Diagnostic Approach to Pancreatic Cancer
Authors: Kobayashi Takashi , Nishiumi Shin , Ikeda Atsuki , Yoshie Tomoo , Sakai Aya , Matsubara Atsuki , Izumi Yoshihiro , Tsumura Hidetaka , Tsuda Masahiro , Nishisaki Hogara , Hayashi Nobuhide , Kawano Seiji , Fujiwara Yutaka , Minami Hironobu , Takenawa Tadaomi , Azuma Takeshi , Yoshida Masaru 
Published: March 2013

Abstract
Background: To improve the prognosis of patients with pancreatic cancer, more accurate serum diagnostic methods are required. We used serum metabolomics as a diagnostic method for pancreatic cancer.
Methods: Sera from patients with pancreatic cancer, healthy volunteers, and chronic pancreatitis were collected at multiple institutions. The pancreatic cancer and healthy volunteers were randomly allocated to the training or the validation set. All of the chronic pancreatitis cases were included in the validation set. In each study, the subjects' serum metabolites were analyzed by gas chromatography mass spectrometry (GC/MS) and a data processing system using an in-house library. The diagnostic model constructed via multiple logistic regression analysis in the training set study was evaluated on the basis of its sensitivity and specificity, and the results were confirmed by the validation set study.
Results: In the training set study, which included 43 patients with pancreatic cancer and 42 healthy volunteers, the model possessed high sensitivity (86.0%) and specificity (88.1%) for pancreatic cancer. The use of the model was confirmed in the validation set study, which included 42 pancreatic cancer, 41 healthy volunteers, and 23 chronic pancreatitis; that is, it displayed high sensitivity (71.4%) and specificity (78.1%); and furthermore, it displayed higher sensitivity (77.8%) in resectable pancreatic cancer and lower false-positive rate (17.4%) in chronic pancreatitis than conventional markers.
Conclusions: Our model possessed higher accuracy than conventional tumor markers at detecting the resectable patients with pancreatic cancer in cohort including patients with chronic pancreatitis.
Impact: It is a promising method for improving the prognosis of pancreatic cancer via its early detection and accurate discrimination from chronic pancreatitis. Cancer Epidemiol Biomarkers Prev; 22(4); 571–9. ©2013 AACR.
Dairy Intakes in Older Girls and Risk of Benign Breast Disease in Young Women
Authors: Berkey Catherine S. , Willett Walter C. , Tamimi Rulla M. , Rosner Bernard , Frazier A. Lindsay , Colditz Graham A. 
Published: March 2013

Abstract
Previous investigations found high dairy intakes in girls associated with rapid height growth and excess weight gain, which had opposite relationships with benign breast disease (BBD) in young women. We use data from the longitudinal Growing Up Today Study (GUTS) to investigate whether dairy intakes, in older children/adolescents, are associated with BBD risk in young women. GUTS includes 9,039 females, ages 9–15 years in 1996, who completed questionnaires annually through 2001, then in 2003, 2005, 2007, and 2010. Dietary food frequencies (1996–2001) obtained milk, yogurt, and cheese intakes. On 2005–2010 surveys, 7,011 females (18–29 years) reported whether a health care provider ever diagnosed them with BBD (n = 250) and if confirmed by breast biopsy (n = 105). Logistic regression models estimated associations between prevalent biopsy-confirmed BBD and dairy intakes, adjusted for age and energy. Multivariable-adjusted models additionally included menarche age, childhood adiposity, adolescent alcohol consumption, and pregnancy. Further analyses stratified by family history. Age-energy–adjusted models of dairy (milk, yogurt, cheese, total dairy servings, dairy protein, dairy fat) intakes at 14 yr found no significant associations with BBD risk [milk: OR, 0.90/(serving/d); 95% confidence interval (CI), 0.76–1.05; dairy protein: OR, 0.98/(10 g/d); 95% CI, 0.82–1.17). Separate analyses of dairy intakes at 10 yr, intakes before the growth spurt, during the growth spurt, before menses-onset, and after menses-onset provided no significant associations with BBD. Multivariable adjustment, and family history stratification, did not alter the above findings. We conclude that dairy intakes by older girls have no strong relation with BBD risk in young women. Because of small number of cases, it is important to continue follow-up and re-examine later. Cancer Epidemiol Biomarkers Prev; 22(4); 670–4. ©2013 AACR.
Bisphosphorylated PEA-15 Sensitizes Ovarian Cancer Cells to Paclitaxel by Impairing the Microtubule-Destabilizing Effect of SCLIP
Authors: Xie Xuemei , Bartholomeusz Chandra , Ahmed Ahmed A. , Kazansky Anna , Diao Lixia , Baggerly Keith A. , Hortobagyi Gabriel N. , Ueno Naoto T. 
Published: March 2013

Abstract
Paclitaxel is a standard chemotherapeutic agent for ovarian cancer. PEA-15 (phosphoprotein enriched in astrocytes-15 kDa) regulates cell proliferation, autophagy, apoptosis, and glucose metabolism and also mediates AKT-dependent chemoresistance in breast cancer. The functions of PEA-15 are tightly regulated by its phosphorylation status at Ser104 and Ser116. However, the effect of PEA-15 phosphorylation status on chemosensitivity of cancer cells remains unknown. Here, we tested the hypothesis that PEA-15 phosphorylated at both Ser104 and Ser116 (pPEA-15) sensitizes ovarian cancer cells to paclitaxel. We first found that knockdown of PEA-15 in PEA-15–high expressing HEY and OVTOKO ovarian cancer cells resulted in paclitaxel resistance, whereas re-expression of PEA-15 in these cells led to paclitaxel sensitization. We next found that SKOV3.ip1-DD cells (expressing phosphomimetic PEA-15) were more sensitive to paclitaxel than SKOV3.ip1-AA cells (expressing nonphosphorylatable PEA-15). Compared with SKOV3.ip1-vector and SKOV3.ip1-AA cells, SKOV3.ip1-DD cells displayed reduced cell viability, inhibited anchorage-independent growth, and augmented apoptosis when treated with paclitaxel. Furthermore, HEY and OVTOKO cells displayed enhanced paclitaxel sensitivity when transiently overexpressing phosphomimetic PEA-15 and reduced paclitaxel sensitivity when transiently overexpressing nonphosphorylatable PEA-15. These results indicate that pPEA-15 sensitizes ovarian cancer cells to paclitaxel. cDNA microarray analysis suggested that SCLIP (SCG10-like protein), a microtubule-destabilizing protein, is involved in pPEA-15–mediated chemosensitization. We found that reduced expression and possibly posttranslational modification of SCLIP following paclitaxel treatment impaired the microtubule-destabilizing effect of SCLIP, thereby promoting induction of mitotic arrest and apoptosis by paclitaxel. Our findings highlight the importance of pPEA-15 as a promising target for improving the efficacy of paclitaxel-based therapy in ovarian cancer. Mol Cancer Ther; 12(6); 1099–111. ©2013 AACR.
Outcomes After Acute Myocardial Infarction in HIV-Infected Patients
Authors: Lorgis Luc , Cottenet Jonathan , Molins Guillaume , Benzenine Eric , Zeller Marianne , Aube Hervé , Touzery Claude , Hamblin Joelle , Gudjoncik Aurélie , Cottin Yves , Quantin Catherine 
Published: March 2013

Background—
We aimed to assess in-hospital case fatality and 1-year prognosis in HIV-infected patients with acute myocardial infarction.

Methods and Results—

From the PMSI (Program de Medicalisation des Systèmes d’informatique) database, data from 277 303 consecutive acute myocardial infarction patients hospitalized from January 1, 2005, to December 31, 2009, were analyzed. Surviving patients were followed up for 1 year after discharge. HIV-infected patients were compared with uninfected patients. Among the cohort, HIV-infected patients (n=608) accounted for 0.22%. All-cause hospital and 1-year mortality rates were lower in the HIV-infected group than in uninfected patients (3.1% versus 8.1% [
P
<0.001] and 1.4% versus 5.5% [
P
<0.001], respectively). From the database, we then analyzed a cohort derived from a matching procedure, with 1 HIV patient matched with 2 patients without HIV, based on age and sex (n=1824). Ischemic cardiomyopathy was more frequent in the HIV group (7.6% versus 4.2%,
P
=0.003). Hospitalization and 1-year mortality rates were similar in the 2 groups (3.1% versus 2.1% [
P
=0.168] and 1.4% versus 1.7% [
P
=0.642], respectively). However, at 12 months, hospitalizations for episodes of heart failure were significantly more frequent in HIV-infected than in uninfected patients (3.3% versus 1.4%, respectively;
P
=0.020). HIV infection, diabetes mellitus, history of ischemic cardiomyopathy, and undergoing percutaneous coronary intervention were associated in univariate analysis with occurrence of heart failure. By multivariable analysis, HIV infection (odds ratio 2.82, 95% confidence interval 1.32–6.01), diabetes mellitus, and undergoing percutaneous coronary intervention remained independent predictors of heart failure.

Conclusions—
The present study demonstrates that after acute myocardial infarction, HIV status influences long-term risk, although the short-term risk in HIV patients is comparable to that in uninfected patients.
How the Devil Got His Hooves and Horns: The Origin of the Motif and the Implied Demonology of 3 Baruch
Authors: Kulik Alexander 
Published: March 2013

Abstract
This paper reexamines the problem of the origins of a popular medieval and modern image of the devil as an anthropomorphic creature with hooves and horns and seeks to reconstruct the analogous ancient image of a satyr-like devil as it could be witnessed in diverse sources, including Hellenistic mythology, rabbinic legends, and early Christian texts. It seems that, not belonging completely to any of these worlds, this therianthropic motif emerges from a complicated literary history wherein Greco-Roman Pan, Jewish seirim, and other mythological figures graft themselves and their imagery around the forces of the demonic. The main argument of the paper as a whole centers around the place of 3 Baruch in this complicated history. This composition may contain the only physical description and detailed treatment of demonic seirim-satyrs in early Jewish literature and the earliest notion of satyr-like demons available to us.
Origen in Augustine: A Paradoxical Reception
Authors: Ramelli Ilaria L.E. 
Published: March 2013

Abstract
I argue that, paradoxically, Augustine embraced much of Origen’s system, especially in his anti-Manichaean polemic, exactly when he was convinced that he did not know his thought. The most remarkable point in his initial adherence to Origen’s ideas regards the apokatastasis doctrine, which he later condemned as heretical and felt the need to recant in his Retractationes (Second Thoughts). I point out many other elements of contact concerning philosophical arguments and Biblical exegesis, which the early Augustine drew from Origen and have escaped scholars who have investigated the Origen-Augustine relationship. With this I shall hopefully add an important piece to the study of Origen’s influence on Western Patristics. I thus explain how Augustine used Origen’s thought in defense of Christian orthodoxy against the Manichaean “heresy,” whereas, after he was informed about Origen’s thought by Horosius and Jerome, he began to find it heretical and condemned it, especially in De civitate Dei (The City of God) and De haeresibus (On Heresies), where he shows that he was misinformed about it. A remarkable role in this transformation was played by Augustine’s ­anti-Pelagian polemic: several of his expressions of blame directed against Origen’s ideas are found in his anti-Pelagian works. Another notable factor was Augustine’s ignorance of the important semantic distinction between αἰώνιος and ἀΐδιος, which got lost in the translation of both with aeternus. Moreover, I endeavor to clarify the ways and sources through which Augustine came to know Origen’s true thought when he did adhere to it, probably without being aware that it was Origen’s.
Animal-Assisted Interventions and Psychiatric Disorders: Knowledge and Attitudes among General Practitioners, Psychiatrists, and Psychologists
Authors: Berget Bente , Grepperud Sverre , Aasland Olaf G. , Braastad Bjarne O. 
Published: March 2013

Abstract
There appears to be a growing interest among farmers and researchers in animal-assisted interventions (AAI). However, less is known about the attitudes toward the use of such interventions among therapists. In this study, Norwegian general practitioners, psychiatrists, and psychologists were asked about their knowledge of, and experience with, AAI and their motivation for learning more about AAI. About two-thirds of the respondents had some or significant knowledge of AAI and were motivated to adapt AAI to their own practice. Almost 9 out of 10 thought that AAI should be used more in psychiatric treatment; however, GPs were not as positive as the psychiatrists/psychologists. More than 2 out of 3 respondents wanted to learn more about AAI, the men being more positive than the women. There were no professional differences on this question, while number of years with clinical work was negatively related, and earlier experiences with AAI positively related, to this motivation to learn more about AAI. Belief in treatment effects was a positive predictor.
Redesigning the Donation Box: The Effect of Animal Banks on Donations for Animal Welfare
Authors: Guéguen Nicolas 
Published: March 2013

Abstract
Some recent studies have shown that physical objects present in the environment can affect altruism. This effect was demonstrated in the context of fundraising for animals. Different banks were placed near the cash register in eight bakeries with a message explaining that the solicitation was for animal welfare. The banks were either in the shape of a dog, a cat, a cow, a pig, or a classic cube. Results showed that more donations were given with the dog and cat banks, whereas no difference in donations was found among the three other banks.
The Census of the Israelites on the Plains of Moab (Numbers 26): Sources and Redaction
Authors: Kislev Itamar 
Published: March 2013

Abstract
In its present form, the census description in Numbers 26 can be identified as the product of a protracted literary process. Three principal stages of composition may be discerned as: a) close reliance on the list in Genesis 46 produced a census description and a list of the Israelite clans when they left Egypt ; b) the displacement of the original list from its original location to its extant position, wherein it serves as a “database” for the allocation of Canaan in accordance with the size of the tribes; c) the text reflected in the MT, in which the original form of the list was changed to better fit the new context, thereby establishing a greater similitude between Numbers 26 and other parts in its literary context.
David and Hattushili III: The Impact of Genre and a Response to J. Randall Short
Authors: Knapp Andrew 
Published: March 2013

Abstract
This article has two components. The first is a theoretical discussion of genre, in which two distinct approaches are outlined. Literary genre theory, which has prevailed in biblical scholarship of the past century, is useful but has certain limitations since a literary genre is an historically situated category. Rhetorical genre theory, on the other hand, defines genre in a transhistorical way that allows one to employ it in situations where literary genre theory does not apply, such as when comparing texts from different cultures and time periods.
The second part of the article illustrates the preceding through a response to J. Randall Short’s recent monograph, The Surprising Election and Confirmation of King David. The article submits that Short employs an unsound understanding of genre, treating apologetic—a transhistorical phenomenon that appears in all human cultures in various forms—as a literary genre instead of a rhetorical genre.
The Form and Function of a Biblical Blood Ritual
Authors: Meshel Naphtali S. 
Published: March 2013

Abstract
There is a consensus in current research that Levitical law never requires blood to be tossed upon the upper surface of the altar. This conception has reinforced—and has been reinforced by—an understanding that yhwh is never to be offered blood. However, it appears that according to several priestly texts, the blood of many sacrifices, including wellbeing, whole-burnt and reparation offerings, is to be tossed upon the upper surface of the altar.
Wisdom as an Immanent Event in Job 28, Not a Transcendent Ideal
Authors: Hankins Davis 
Published: March 2013

AbstractJob 28 poses several interpretive difficulties: its reflections about wisdom seem disembodied and misplaced within the dialogue; its content, especially the final verse, seems ill-fit for the issues the book raises. Much interpretive discomfort with the poem stems from the misconception that it presents human inaccessibility to wisdom in opposition to God’s accessibility. By reassessing the poem as moving rhetorically from a metonymic (in vv.1-19) to a metaphoric logic (in vv.20-28), this article demonstrates that wisdom is displaced throughout the poem—from humans, God, and creation. Job 28 primarily opposes two different ways of relating to this displaced wisdom: the metonymic search that evokes wisdom as perpetually transcendent, versus the discovery of wisdom in metaphoric effects that appear as displaced from their causes. This reinterpretation enables more nuanced readings of v.28 as an appositive metaphor, and of the poem’s displacement in the book as appropriate to its teachings about wisdom.
Aus der Welt eines Gefangenen Die Kommunikationsstruktur des Philipperbriefs im Spiegel seiner Abfassungssituation
Authors: Standhartinger Angela 
Published: March 2013

Abstract
It is well known that Philippians was written in prison. However, very few have investigated whether the living conditions of ancient imprisonment are reflected in Philippians. Even less frequently studied are the specific structures of communication for those in Roman custody. This article argues that the situation of composition in prison demanded a degree of ambiguity in speaking and writing that produced difficulties for interpreters of Philippians then and now. For a letter written in prison has to reckon with being read by more than the immediate addressees, like the prison guards, police personnel, and judges. Thus, a letter from prison is always an “open interaction between the subordinates and those who dominate,” or, as James Scott has called it, a “public transcript.” The question, however, arises, whether behind the public transcript, that is the letter to the Philippians, we may also discover a hidden transcript, a discourse that takes place “offstage,” beyond direct observation by power holders. This article seeks to clarify what Paul is conveying in Philippians by reading it against ancient prison life and the circumstances of writing and communicating from therein. It finally asks how the community in Philippi might have read the letter beyond what is (and is not) obviously communicated in it.
Die Perikope von der Hochzeit zu Kana ( Joh 2:1-11) im Kontext der Spätantike
Authors: Förster Hans 
Published: March 2013

Abstract
One focus of the interpretation of the Wedding at Cana ( John 2:1-11) is usually the abundance of wine. The amount of water in the six large jars, which is changed into wine, seems to be enormous. However, the amount is traditionally not put into the context of the average consumption of wine in antiquity. Archaeological and papyrological sources suggest that—in the context of antiquity—the amount seems not to be extraordinarily large. Rather, the amount of wine seems to be sufficient just for a “common household.” This is important for the interpretation of the entire passage: The “abundance of wine” is very often related to the hypothesis that this supposed abundance is to be seen in the context of the attempt to surpass the cult of Dionysos.
Potential recovery of a declined turtle population diminished by a community shift towards more generalist species
Authors: Pitt Amber L. , Pitt Amber L. , Nickerson Max A. 
Published: March 2013

Models suggest that a declined turtle population may rebound if the cause of decline is remedied and adult mortality is reduced, but recovery time will likely be slow. In 2005-2007, we reexamined a river turtle community which included a population of Northern Map Turtles (Graptemys geographica) that had been reduced by approximately 50% between 1969 and 1980 likely as a result of harvesting, and had failed to rebound by 2004 despite no evidence of continued harvesting. Comparisons of population estimates for G. geographica showed no significant differences between 2005 and 2006 (, ) or between 2006 and 2007 (, ). However, the population estimate for 2007 was not significantly different from the population estimate for 1969 (, ) but was significantly higher than the population estimate for 1980 (, ), suggesting the population had returned to its pre-decline (1969) size. While the recovery of the G. geographica population demonstrates that a previously harvested river turtle population may rebound if no further harvesting occurs, the recovery period will be extensive, thus confirming model predictions. Furthermore, the turtle community composition was shifting towards a higher relative abundance of generalist species and a lower relative abundance of specialist species – a pattern that can be expected with habitat degradation, another threat which may present new challenges to G. geographica, a dietary specialist.
Description of Trichodorus japonicus n. sp. (Triplonchida: Trichodoridae) from Japan
Authors: Zhao Lirong , Xie Hui , Gu Jianfeng , Xu Chunling 
Published: March 2013

Trichodorus japonicus n. sp. was intercepted from soil around roots of Acer palmatum and Camellia japonica imported from Japan. It is characterised in the male by having three ventromedian cervical papillae between the onchiostyle base and the secretory-excretory pore, nearly straight or slightly ventrally curved spicules with a finely striated blade except at extremities, three (rarely four) ventromedian precloacal supplements, the posterior supplement (SP1) opposite the middle of the retracted spicules, the presence of a bursa-like thickening, and terminal tail cuticle not or only slightly thickened. The female has a pore-like vulva in ventral view, pear-shaped to cylindrical-shaped vagina, vagina length 36% (31-41%) of the corresponding body diam., vaginal sclerotised pieces 1.9-2.5 μm in size, triangular to rounded triangular in lateral view and slightly separated (1-2 μm), and a pair of ventrosubmedian to ventrosublateral advulvar body pores (located within one-third body diam. posterior to vulva). The results of phylogenetic analysis based on the rDNA-ITS2 and 28S-D2/D3 sequences data using UPGMA (Unweighted pair group method using arithmetic average) and ME (Minimum Evolution) confirmed the close relationships of T. japonicus n. sp. with T. cedarus, T. paracedarus and T. nanjingensis.
Cementing Class Differences: Globalization in Peru
Authors: Ko Nusta Carranza 
Published: March 2013

Abstract
Critics of globalization address how international trade creates inequality and induces class differences in the international global system. Reflecting these thoughts, this paper examines the effects of economic globalization, international trade, and neoliberal-oriented economic policies on cementing class differences in Peru. Through a qualitative assessment of various international trade agreements, Peru’s membership in the regional trade bloc, and the continuing flow of foreign investment into Peru’s textile and natural resource industries, I determine that the so-called “benefits” of economic globalization have yet to reach the Peruvian socio-economic minority and have instead helped in maintaining the class differences in this South American state.