bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cell cycle‐dependent expression of p42.3 promotes mitotic progression in malignant transformed cells
Authors: Mao Linlin , Sun Wei , Li Wenmei , Cui Jiantao , Zhang Jingyu , Xing Rui , Lu Youyong 
Published: November 2012

AbstractIn an earlier study, we cloned the p42.3 gene and showed that its expression was specific to tumors in a number of tumor cell lines and primary tumor tissues. However, the biological role and function of this gene remains largely unknown. In this study, p42.3 expression was found to be cell cycle‐dependent at both the mRNA and protein levels in several human tumor cell lines. Typically, abundant expression was detected at G1 and M phases compared with S and G2 phases. Expression peaked at early G1 phase then decreased drastically at late G1, S, and G2. Furthermore, transfection of the p42.3 gene into NIH3T3 cells promoted malignant transformation, accompanied by accelerated mitotic progression and altered chromosome segregation. It was also observed that Cyclin B1 was upregulated and Cdc2‐Tyr15 was downregulated following p42.3 overexpression in NIH3T3 cells. Combined, these results indicate that p42.3 as a cell cycle‐regulated gene contributes to promoting cell cycle progression through disruption of mitotic regulation, and may play important roles in malignant transformation. © 2012 Wiley Periodicals, Inc.
Evolution of PLS for Modeling SAR and omics Data
Authors: Hasegawa Kiyoshi , Funatsu Kimito 
Published: November 2012

AbstractIn quantitative structure‐activity relationship (QSAR), multivariate statistical methods are commonly used for data analysis. Partial least squares (PLS) is of particular interest because it can analyze data with strongly collinear, noisy and numerous X variables, and also simultaneously models several activity variables Y. PLS provides several prediction regions and diagnostic plots as statistical measures. PLS has evolved for coping with the severe demands imposed by complex data structures. In this review article, we outline the algorithms of five advanced PLS techniques and provide some representative examples of each. The selected models are Nonlinear PLS, Multiway PLS, Hierarchical PLS, Orthogonal PLS, and Bi‐modal PLS. Studies of particular aspects of living cells (such as the set of genes or proteins in the cell and their interactions) are collectively known as the ‐omics fields. Omics integrate heterogeneous scientific disciplines and include chemogenomics, proteomics, and metabolomics. The datasets produced within the omics fields are numerous, megavariate and extremely complex. The data structures are frequently incomplete, noisy, nonlinear and collinear demanding modern and powerful multivariate data analysis methods. In particular, the omics technologies have steered biology towards the adoption of orthogonal PLS. We also describe future prospects for the use of PLS algorithms in the omics fields.
Researching children's health experiences: The place for participatory, child‐centered, arts‐based approaches
Authors: Carter Bernie , Ford Karen 
Published: November 2012

AbstractA central concern when conducting qualitative health research with children is eliciting data that genuinely reflect their perspectives. Invariably, this involves being child‐centered and participatory. Drawing and photography increasingly accompany dialogic methods to facilitate children's communication through arts‐based and verbal modes of expression. However, little literature is available on how arts‐based tools shape data. We suggest that researchers need to be attentive to how such tools can liberate, constrain and frame data generated by children, drawing attention to the promises of such approaches as well as the conundrums that can arise from their use. We explore the place for participatory, child‐centered, arts‐based approaches using examples of the use of drawing and photography in our own studies. © 2012 Wiley Periodicals, Inc. Res Nurs Health 36:95–107, 2013
Assembly of a cohort of children treated for acute myeloid leukemia at free‐standing children's hospitals in the United States using an administrative database
Authors: Kavcic Marko , Fisher Brian T. , Torp Kari , Li Yimei , Huang Yuan‐Shung , Seif Alix E. , Vujkovic Marijana , Aplenc Richard 
Published: November 2012

AbstractPediatric Health Information System data were used to establish a multi‐center cohort of 1,686 children treated for newly diagnosed acute myeloid leukemia (AML). The cohort assembly process, which included myeloid leukemia ICD‐9 discharge diagnosis codes and manual review of induction chemotherapy, was validated by chart review at a single institution. The use of ICD‐9 codes alone resulted in a poor positive predictive value (PPV; 31%). Inclusion of the results from the chemotherapy review improved the PPV to 100% without compromising sensitivity (95.7%). This cohort provides a reliable source for future comparative effectiveness and clinical epidemiology studies in pediatric AML. Pediatr Blood Cancer 2013; 60: 508–511. © 2012 Wiley Periodicals, Inc.
Association of midtrimester short femur and short humerus with fetal growth restriction
Authors: de Carvalho Ana Alice Vidal , Carvalho José Antônio , Figueiredo Israel , Velarde Luis Guillermo Coca , Marchiori Edson 
Published: November 2012

ABSTRACTObjectiveTo investigate the association between the midtrimester presence of short femur and short humerus and intrauterine growth restriction.MethodsThis retrospective study included ultrasound examinations of 1043 fetuses. Fetuses with normal‐length bones were compared with fetuses that had femoral or humeral lengths below the 5th percentile for gestational age by Student's t‐test and the chi‐squared test. The association between short bones and fetal growth restriction development was evaluated by Fisher's exact test. Fetuses with estimated weight below the 10th percentile for gestational age and abnormal umbilical artery flow were considered to have growth restriction.ResultsFemoral and humeral lengths were normal in 974 (93.4%) fetuses; 19 (1.8%) fetuses had short femora, 65 (6.2%) had short humeri, and 15 (1.4%) had short femora and humeri combined. Of fetuses included in the analysis, 603 (57.8%) underwent Doppler examination. Short femur [odds ratio = 9.7, 95% confidence interval = 1.9–50.2, P = 0.03] and short humerus (odds ratio = 13, 95% confidence interval = 4.9–34.6, P < 0.001) were associated with fetal growth restriction.ConclusionFetuses with midtrimester short femur, short humerus, or short femur and humerus combined require more intensive surveillance for growth restriction development. © 2012 John Wiley & Sons, Ltd.
Synthesis, structure, and thermal stability of poly(methyl methacrylate)‐co‐ poly(3‐tri(methoxysilyil)propyl methacrylate)/ montmorillonite nanocomposites
Authors: Carvalho Hudson W.P. , Suzana Ana F. , Santilli Celso V. , Pulcinelli Sandra H. 
Published: November 2012

AbstractThe structure and the thermodegradation behavior of both poly(methyl methacrylate)‐co‐poly(3‐tri(methoxysilyil)propyl methacrylate) polymer modified with silyl groups and of intercalated poly(methyl methacrylate)‐co‐poly(3‐tri(methoxysilyil)propyl methacrylate)/Cloisite 15A™ nanocomposite have been in situ probed. The structural feature were comparatively studied by Fourier transform infrared spectroscopy (FTIR), 13C and 29Si nuclear magnetic resonance (NMR), and small angle X‐ray scattering (SAXS) measurements. The intercalation of polymer in the interlayer galleries was evidenced by the increment of the basal distance from 31 to 45 Å. The variation of this interlayer distance as function of temperature was followed by in situ SAXS. Pristine polymer decomposition pathway depends on the atmosphere, presenting two steps under air and three under N2. The nanocomposites are more stable than polymer, and this thermal improvement is proportional to the clay loading. The experimental results indicate that clay nanoparticles play several different roles in polymer stabilization, among them, diffusion barrier, charring, and suppression of degradation steps by chemical reactions between polymer and clay. Charring is atmosphere dependent, occurring more pronounced under air. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Origin of dielectric response and conductivity of some alicyclic polyimides
Authors: Ioan Silvia , Hulubei Camelia , Popovici Dumitru , Musteata Valentina Elena 
Published: November 2012

AbstractHigh‐performance alicyclic‐containing polyimides for advanced applications, derived from 5‐(2,5‐dioxotetrahydrofurfuryl)‐3‐methyl‐3‐cyclohexene‐1,2‐dicarboxylic acid anhydride or bicyclo[2.2.2]oct‐7‐ene‐2,3,5,6‐ tetracarboxylic dianhydride and two flexible aromatic diamines, were synthesized by a classical two‐step polycondensation reaction. The dielectric spectra behavior over wide frequency and temperature ranges of 1 Hz‐1 MHz and –150°C÷+250°C, respectively, was investigated according to chemical and micro‐structural aspects. The dielectric constants have low values and are dependent on dianhydride flexibility and diamine links, in relation with the charge–transfer complex (CTC) and free volume, and, consequently, with packing of the polymer chains and polarizable groups per volume units. All polyimide films develop two relaxation processes, i.e., γ and β relaxation, involving different enthalpy and entropy contributions induced by their chemical structures. Frequency–temperature‐dependent conductivity showed that conductivity increased with frequency and also that energy bandgap representation could be suitable for explaining the temperature influence on AC‐conductivity. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
Characterization of morphology and gas separation performance of dry‐cast polycarbonate membranes
Authors: Fu Ywu‐Jang , Chen Jung‐Tsai , Chen Chun‐Chieh , Liao Kuo‐Sung , Hu Chien‐Chieh , Lee Kueir‐Rarn , Lai Juin‐Yih 
Published: November 2012

AbstractThe development of the morphology and microstructure in dry‐cast membranes from polycarbonate (PC)/dichloromethane (DCM) and PC/tetrahydrofuran (THF) solutions was investigated in this work. It was shown that changing the relative humidity (RH) of the air altered the transparency and the surface morphology of the membranes. Positron lifetime spectra for membranes with different surface morphology gave similar free volume parameters, which are believed to be mainly responsible for the constant selectivity of the membranes. In this study, the permeation and adsorption properties of the PC membranes cast from PC/DCM and PC/THF solutions were characterized as a function of the RH. Results demonstrated that the permeability of membranes increased with increasing RH of the air. The change in the permeability is presumably related to the forming of pores on the membrane surface due to the vapor‐induced phase separation during casting. POLYM. ENG. SCI., 2013. © 2012 Society of Plastics Engineers
GISAXS study of Si nanostructures in SiO2 matrix for solar cell applications
Authors: Pivac Branko , Dubček Pavo , Capan Ivana , Zorc Hrvoje , Dasović Jasna , Bernstorff Sigrid , Wu Marvin , Vlahovic Branislav 
Published: November 2012

AbstractWe explore the process of Si nanoparticles formation in SiO2 matrix suitable for advanced solar cells application. To this purpose a superstructure consisting of alternating 5 nm thick SiOx and SiO2 layers was deposited by high vacuum evaporation from solid sources. After high temperature annealing of such structures in high vacuum, the SiOx decomposed and Si nanoparticles aggregated at their former position forming therefore a superstructure of Si nanoparticles embedded in dielectric SiO2 matrix. To explore such process of nanoobjects formation in different matrix, grazing incidence small‐angle X‐ray scattering (GISAXS) seems to be as relatively easy non‐destructive technique; a logical choice. Despite the fact that due to the rather small difference in electron density between Si and SiO2. GISAXS contrast is very small, by performing GISAXS with intense synchrotron light and subtracting the dominant surface contribution to the overall signal we managed to retrieve information on the structural changes within the layers. The conclusions from the GISAXS analysis were confirmed by photoluminescence measurements.
Investigation of defect luminescence from multicrystalline Si wafer solar cells using X‐ray fluorescence and luminescence imaging
Authors: Peloso Matthew P. , Palina Natalie , Banas Krzysztof , Banas Agnieszka , Hidayat Hidayat , Hoex Bram , Breese Mark B. H. , Aberle Armin G. 
Published: November 2012

AbstractMulticrystalline silicon wafer solar cells reveal performance‐ reducing defects by luminescence. X‐ray fluorescence spectra are used to investigate the elemental constituents from regions of solar cells yielding reverse‐bias or sub‐bandgap luminescence from defects. It is found that a higher concentration of metals is present in regions yielding reverse‐bias electroluminescence than in regions yielding sub‐bandgap electroluminescence. This suggests, dislocations do not create strong breakdown currents in the absence of impurity precipitates.magnified image(a) Topographies of sub‐bandgap (red) and reverse‐bias (blue) luminescence from defects in a multicrystalline Si wafer solar cell. (b) Their distinct X‐ray spectra indicate highest concentrations of metals in the blue regions.(© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
Auditory support for resection guidance in navigated liver surgery
Authors: Hansen Christian , Black David , Lange Christoph , Rieber Fabian , Lamadé Wolfram , Donati Marcello , Oldhafer Karl J. , Hahn Horst K. 
Published: November 2012

BackgroundAn alternative mode of interaction with navigation systems for open liver surgery was requested. Surgeons who use such systems are impeded by having to constantly switch between viewing the navigation system screen and the patient during an operation.MethodsTo this end, an auditory display system for open liver surgery is introduced with support for guiding the tracked instrument towards and remaining on a predefined resection line. To evaluate the method, a clinically orientated user study with 12 surgeons was conducted.ResultsIt is shown in qualitative results from the user study that the proposed auditory display is recognized as a useful addition to the current visual mode of interaction. It was revealed in a statistical analysis that participants spent less time looking on the screen (10% vs. 96%). Accuracy for resection guidance was significantly improved when using auditory display as an additional information channel (0.6 vs. 1.4 mm); however, the overall time for the resection task was shorter without auditory display (47 vs. 24 s).ConclusionsBy reducing dependence on the visual modality during resection guidance, the auditory display is well suited to become integrated in navigation systems for liver surgery. Copyright © 2012 John Wiley & Sons, Ltd.
Ancestors and descendants in evolving k‐tree models
Authors: Panholzer Alois , Seitz Georg 
Published: November 2012

AbstractWe consider several random graph models based on k‐trees, which can be generated by applying the probabilistic growth rules “uniform attachment”, “preferential attachment”, or a “saturation”‐rule, respectively, but which also can be described in a combinatorial way. For all of these models we study the number of ancestors and the number of descendants of nodes in the graph by carrying out a precise analysis which leads to exact and limiting distributional results. © 2014 Wiley Periodicals, Inc. Random Struct. Alg. 44, 465–489, 2014
Multijunction thermal converter with improved frequency characteristics between 10 Hz and 1 MHz
Authors: Hidaka Shigeru , Kishino Kaname , Shimizume Khoji , Takeda Susumu , Fujiki Hiroyuki , Amagai Yasutaka , Sasaki Hitoshi 
Published: November 2012

AbstractA new multijunction thermal converter (MJTC) for precision AC–DC transfer standard has been developed. A U‐shaped heater pattern was sputter‐deposited onto an AlN plate in order to reduce thermoelectric effect, which causes the frequency‐independent AC–DC transfer difference. Both low‐frequency and high‐frequency characteristics improved as a result of the new configuration, and the AC–DC transfer difference of the MJTC was evaluated to be <1 µV/V between 10 Hz and 100 kHz and <10 µV/V up to 1 MHz. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Optical timing distribution system with femtosecond stability
Authors: Amemiya Masaki , Watabe Ken‐ichi , Suzuyama Tomonari , Naito Takashi , Tsuchida Hidemi 
Published: November 2012

AbstractStable timing distribution is a key technology for the many fields that use timing signals for synchronization. The frequency of the timing signal depends on the field and multiple timing signals are sometimes required. In our DWDM‐based timing distribution system, phase deviation is detected by high‐speed round‐trip signal (10 GHz signal is used as this control signal). Fiber stretchers are controlled so as to minimize the phase deviation of the control signal. Multiple signals and the control signal are densely multiplexed and transmitted through the same stretchers. Therefore, the transmission of all signals is stabilized. This configuration provides a flexible platform for distributing various RF or microwave signals. As an example of arbitrary timing signals, a 1 GHz signal is transmitted over a length‐stabilized 400‐m fiber for more than 1 day. The recorded propagation time fluctuations are 10.4 and 2.8 fs rms for the 1 and 10 GHz signals, respectively. The Allan deviations are 2.7 × 10−19 (1 GHz) and 6.0 × 10−20 (10 GHz) for the averaging time of 105 s. © 2012 Institute of Electrical Engineers of Japan. Published by John Wiley & Sons, Inc.
Direct and Recurrent Inguinal Hernias are Associated with Ventral Hernia Repair: A Database Study
Authors: Henriksen Nadia A. , Sorensen Lars T. , Bay‐Nielsen Morten , Jorgensen Lars N. 
Published: November 2012

AbstractBackgroundA systemically altered connective tissue metabolism has been demonstrated in patients with abdominal wall hernias. The most pronounced connective tissue changes are found in patients with direct or recurrent inguinal hernias as opposed to patients with indirect inguinal hernias. The aim of the present study was to assess whether direct or recurrent inguinal hernias are associated with an elevated rate of ventral hernia surgery.MethodsIn the nationwide Danish Hernia Database, a cohort of 92,457 patients operated on for inguinal hernias was recorded from January 1998 until June 2010. Eight‐hundred forty‐three (0.91 %) of these patients underwent a ventral hernia operation between January 2007 and June 2010. A multivariate logistic regression analysis was applied to assess an association between inguinal and ventral hernia repair.ResultsDirect (Odds Ratio [OR] = 1.28 [95 % CI, 1.08–1.51]) and recurrent (OR = 1.76, [95 % CI, 1.39–2.23]) inguinal hernias were significantly associated with ventral hernia repair after adjustment for age, gender, and surgical approach (open or laparoscopic).ConclusionsPatients with direct and recurrent inguinal herniation are more prone to ventral hernia repair than patients with indirect inguinal herniation. This is the first study to show that herniogenesis is associated with type of inguinal hernia.
Excessive Decrease in Serum Magnesium After Total Thyroidectomy for Graves’ Disease Is Related to Development of Permanent Hypocalcemia
Authors: Hammerstad Sara Salehi , Norheim Ingrid , Paulsen Trond , Amlie Lise Marit , Eriksen Erik Fink 
Published: November 2012

AbstractBackgroundTransient postoperative hypocalcemia is one of the most common complications after thyroidectomy. Permanent hypocalcemia, however, is rare, but usually requires life‐long treatment and follow‐up. The risk of permanent hypocalcemia has been shown to be significantly higher in patients with Graves’ disease. In the present study we evaluated short‐term and long‐term changes in serum calcium, phosphate, magnesium, and parathyroid hormone (PTH) levels in order to characterize subjects at risk of postoperative hypoparathyroidism.MethodsForty patients who underwent total thyroidectomy for Graves’ disease were included in the study. Calcium, phosphate, magnesium, and PTH were measured before surgery and regularly during the year that followed.ResultsPostoperative hypocalcemia was seen in 21/40 (53 %) patients. Undetectable PTH (<0.6 pmol/L) was registered in 11/40 (27 %) patients. All patients with measurable PTH 6–48 h after operation regained normal calcium. Of those with undetectable PTH after 6–48 h, four developed permanent hypocalcemia. We found a significantly lower serum calcium level before operation in patients who developed permanent hypocalcemia compared to those who did not (p < 0.001). We also found a significant correlation between the decrease in serum magnesium from time 0 to 48 h after operation and permanent hypocalcemia (p = 0.015).ConclusionsSerum calcium prior to operation, serum PTH, and degree of decrease in magnesium levels in serum 48 h after operation may predict development of permanent hypocalcemia. Magnesium plays an important role in calcium homeostasis via stimulation of PTH secretion and modulation of PTH receptor sensitivity. Both mechanisms may have played a role for the findings reported in this article.
Surgery and Anesthesia Capacity‐Building in Resource‐Poor Settings: Description of an Ongoing Academic Partnership in Uganda
Authors: Lipnick Michael , Mijumbi Cephas , Dubowitz Gerald , Kaggwa Samuel , Goetz Laura , Mabweijano Jacqueline , Jayaraman Sudha , Kwizera Arthur , Tindimwebwa Joseph , Ozgediz Doruk 
Published: November 2012

AbstractBackgroundSurgery and perioperative care have been neglected in the arena of global health despite evidence of cost‐effectiveness and the growing, substantial burden of surgical conditions. Various approaches to address the surgical disease crisis have been reported. This article describes the strategy of Global Partners in Anesthesia and Surgery (GPAS), an academically based, capacity‐building collaboration between North American and Ugandan teaching institutions.MethodsThe collaboration’s projects shift away from the trainee exchange, equipment donation, and clinical service delivery models. Instead, it focuses on three locally identified objectives to improve surgical and perioperative care capacity in Uganda: workforce expansion, research, collaboration.ResultsRecruitment programs from 2007 to 2011 helped increase the number of surgery and anesthesia trainees at Mulago Hospital (Kampala, Uganda) from 20 to 40 and 2 to 19, respectively. All sponsored trainees successfully graduated and remained in the region. Postgraduate academic positions were created and filled to promote workforce retention. A local research agenda was developed, more than 15 collaborative, peer‐reviewed papers have been published, and the first competitive research grant for a principal investigator in the Department of Surgery at Mulago was obtained. A local projects coordinator position and an annual conference were created and jointly funded by partnering international efforts to promote collaboration.ConclusionsSub‐Saharan Africa has profound unmet needs in surgery and perioperative care. This academically based model helped increase recruitment of trainees, expanded local research, and strengthened stakeholder collaboration in Uganda. Further analysis is underway to determine the impact on surgical disease burden and other important outcome measures.