bluuebunny/crossref_metadata_2025_split huggingface dataset:
Levels of TNF‐α, soluble TNF receptors (sTNFR1, sTNFR2), and cognition in bipolar disorder
Authors: Doganavsargil‐Baysal Ozge , Cinemre Buket , Aksoy Umut Mert , Akbas Halide , Metin Ozmen , Fettahoglu Cıgıl , Gokmen Zehra , Davran Fatih 
Published: March 2013

ObjectiveTumor necrosis factor‐alpha (TNF‐α) may play an important role in bipolar disorder (BD) pathogenesis. There is only one study about a relationship between TNF‐α levels and cognitive impairments in BD. The aim of the present study was to see whether TNF‐α, soluble P55 TNF receptor (sTNFR1), and soluble P75 TNF receptor (sTNFR2) levels in BD patients are different from controls and to investigate the relationships between the levels of TNF‐α, sTNFR1, and sTNFR2 and the cognitive functions in euthymic BD patients and controls.MethodsWe assessed 54 BD type I patients and 18 controls by using a battery of neuropsychological tests. Serum TNF‐α levels were measured using a commercially available enzyme‐linked immunosorbent assay, whereas serum sTNFR1 and sTNFR2 levels were measured using a commercially enzyme‐amplified sensitivity immunoassay kit.ResultsWe found that levels of sTNFR1 and sTNFR2 in BD patients were different from controls. No difference was detected between the BD group and the control group for levels of TNF‐α. TNF‐α level was found to have a negative correlation with the delayed recall in RAVLT.ConclusionsHigh levels of sTNFR1 and sTNFR2 in euthymic patients showed that it may support that proinflammatory process continues in euthymic period. This is the first study which showed increased sTNFR2 levels in euthymic period, which could be interpreted as a compensatory mechanism and again the first which deals with verbal memory. Copyright © 2013 John Wiley & Sons, Ltd.
A NON‐LINEAR MODEL FOR OPTIMAL ALLOCATION OF IRRIGATION WATER AND LAND UNDER ADEQUATE AND LIMITED WATER SUPPLIES: A CASE STUDY IN SOUTHERN ITALY
Authors: Rubino Pietro , Stellacci Anna Maria , Rana Roberta M. , Catalano Maurizia , Caliandro Angelo 
Published: March 2013

ABSTRACTA non‐linear mathematical optimization model was used to define optimal water and land allocation and optimal cropping patterns for a southern Italy irrigation district. The objective function was based on crop‐water production relations, the parameters of which were derived from an extensive experimental data set including nine arable and vegetable crops. Among production costs, the irrigation binary tariff system adopted in the study region was considered. The study, performed across a wide range of total water supply, identified: (i) optimal water allocation, by keeping crop surface constant; (ii) optimal cropping patterns, when allocation of available land was also investigated. When a fixed surface was allocated to each crop, and total water supply was not limiting, maximum return was achieved by providing the greatest fraction of available water to vegetable crops (pepper, tomato, eggplant, beans), with seasonal volumes corresponding to full restitution of irrigation water requirements (from 6758 to 3571 m3 ha‐1), while assigning volumes equal to 78, 62, 48 and 41% of water requirements to summer and spring maize, autumnal and spring sugar beet. When the allocation of water and land was investigated simultaneously, optimal cropping patterns and seasonal volumes were identified. The latter varied as a function of crop and total water supply but also, at a given supply, for the same crop. Copyright © 2013 John Wiley & Sons, Ltd.
Using Apps to Support Disciplinary Literacy and Science Learning
Authors: Castek Jill , Beach Richard 
Published: March 2013

AbstractApps, specialized programs used on mobile computers, can be used in innovative ways to enhance science and literacy learning. With the skilled guidance of their teachers, students can exploit app affordances for learning and acquire disciplinary literacies unique to science. This article showcases apps that help students to access information, make sense of it, and create their own products that include rich visual representations. We also describe teaching approaches that support the close reading of science texts through the use of note‐taking and annotation apps. Classroom examples that are featured illustrate that these app affordances are not simply in the apps, but rather, fostered by how the teachers exploit these affordances to achieve their own particular learning objectives. As we become more familiar with new apps as educational tools, we need to be mindful about how these tools strategically in ways that best enhance our students’ own learning.
Literacies in the Body
Authors: Jones Stephanie 
Published: March 2013

AbstractIn this commentary, the the author invites readers to consider the body and its central place in literacy pedagogy, practice and research. She emphasizes two interrelated paths for teachers and researchers interested in literacies to tend to the body: (1) the ways literacies are engaged and cultivated for making senseofbodies, and (2) the literacies embedded in, performed through, and experiencedasbodies. Drawing on poststructural theories and her analysis of round robin reading, the author reminds readers that literacies are not inherently good, and educators concerned with issues of inequities and injustice can study and reimagine the literacies in bodies that propel too many of us forward in an automaton fashion.
Effects of freezing/thawing on the mechanical properties of decellularized lungs
Authors: Nonaka Paula N. , Campillo Noelia , Uriarte Juan J. , Garreta Elena , Melo Esther , de Oliveira Luis V. F. , Navajas Daniel , Farré Ramon 
Published: March 2013

AbstractLung bioengineering based on decellularized organ scaffolds is a potential alternative for transplantation. Freezing/thawing, a usual procedure in organ decellularization and storage could modify the mechanical properties of the lung scaffold and reduce the performance of the bioengineered lung when subjected to the physiological inflation‐deflation breathing cycles. The aim of this study was to determine the effects of repeated freezing/thawing on the mechanical properties of decellularized lungs in the physiological pressure–volume regime associated with normal ventilation. Fifteen mice lungs (C57BL/6) were decellularized using a conventional protocol not involving organ freezing and based on sodium dodecyl sulfate detergent. Subsequently, the mechanical properties of the acellular lungs were measured before and after subjecting them to three consecutive cycles of freezing/thawing. The resistance (RL) and elastance (EL) of the decellularized lungs were computed by linear regression fitting of the recorded signals (tracheal pressure, flow, and volume) during mechanical ventilation. RL was not significantly modified by freezing‐thawing: from 0.88 ± 0.37 to 0.90 ± 0.38 cmH2O·s·mL−1 (mean ± SE). EL slightly increased from 64.4 ± 11.1 to 73.0 ± 16.3 cmH2O·mL−1 after the three freeze‐thaw cycles (p = 0.0013). In conclusion, the freezing/thawing process that is commonly used for both organ decellularization and storage induces only minor changes in the ventilation mechanical properties of the organ scaffold. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 413–419, 2014.
Osteoblastic cell response on biphasic fluorhydroxyapatite/strontium‐substituted hydroxyapatite coatings
Authors: Yin Ping , Feng Fang Fang , Lei Ting , Zhong Xiao Huan , Jian Xin Chun 
Published: March 2013

AbstractFluorhydroxyapatite/strontium‐substituted hydroxyapatite (FHA/SrHA) biphasic coatings with F and Sr elements incorporated simultaneously into one coating layer were prepared on titanium substrate via colloidal sol–gel method. The bioactivity of the as‐prepared FHA/SrHA biphasic coatings was evaluated in vitro by immersion in simulated body fluid (SBF). All the biphasic coatings exhibited great ability to induce apatite precipitation on their surfaces. In vitro cell responses were evaluated using osteoblast‐like MG63 cells in terms of cell proliferation and differentiation (alkaline phosphatase activity and osteocalcin level). The biphasic coatings show significantly positive effects on the viability and functional activity of osteoblastic cells with clear evidence that an optimum SrHA amount dose exists, indicating that the coexistence of FHA and SrHA had a synergistic stimulatory effect. This finding suggests the potential use of this colloidal sol–gel derived FHA/SrHA biphasic coatings for hard tissue applications. © 2013 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 102A: 621–627, 2014.
Tonoplast Na+/H+ antiporters of newly developed maize (Zea mays) hybrids contribute to salt resistance during the second phase of salt stress
Authors: Pitann Britta , Mohamed Abdel‐Kareem , Neubert Anja B. , Schubert Sven 
Published: March 2013

AbstractTo investigate the role of tonoplast Na+/H+ antiporters (ZmNHX) in salt‐stress resistance newly developed maize (Zea mays L.) SR hybrids and cv. Across 8023 were tested under low (50 mM NaCl) and high salinity (200 mM NaCl). Resistance to Na+ toxicity was monitored in terms of shoot growth and number of necrotic leaf spots. At high salinity, the SR hybrids showed better shoot growth than Across 8023. SR 03 and SR 05 had a lower number of necrotic spots per leaf compared to SR 20 and Across 8023. Based on these results, SR 03 and SR 05 were classified as salt‐resistant, and SR 20 and Across 8023 as salt‐sensitive genotypes. At 200 mM NaCl, the salt‐resistant hybrids SR 03 and SR 05 showed a significant upregulation of the tonoplast Na+/H+ antiporter (ZmNHX) in leaves compared with Across 8023 and SR 20. The salt stress–induced increase in transcription of ZmNHX may lead to enhanced tonoplast Na+/H+ antiport in leaves for SR 03 and SR 05. Hence, sequestration of Na+ into leaf vacuoles contributes to salt resistance of these genotypes by protecting the cytoplasm from Na+ toxicity. Relative transcription of ZmNHX in roots was only increased in SR 20, which may explain the efficient Na+ exclusion from shoots of SR 20.
Depressive Symptoms in Bereaved Parents in the 2008 Wenchuan, China Earthquake: A Cohort Study
Authors: Liu Wumei , Fan Fang , Liu Jianghong 
Published: March 2013

This study sought to expand the literature on bereavement and response to natural disasters by reporting the prevalence, severity, and correlates of depressive symptoms among bereaved and nonbereaved parents of the 2008 Wenchuan Earthquake in China. Bereaved (n = 155) and nonbereaved (n = 35) parents from the Xiang'e township in China were interviewed at 18 months (Wave 1) and 24 months (Wave 2) following the earthquake. From Wave 1 to Wave 2, rates of probable depression fell for both bereaved (65.8% to 44.5%) and nonbereaved parents (34.3% to 20.0%). The depression index of both groups also decreased, but only significantly among bereaved parents. Of bereaved parents, those with fewer years of education had more severe symptoms at both waves. Depressive symptom severity of bereaved mothers improved over time, but that of bereaved fathers remained unchanged. Not becoming pregnant again after the earthquake was significantly linked to worse depressive symptoms in both waves, but this was not significant when age was added to the model. Bereaved parents may need more postearthquake supportive services, with fathers, individuals with fewer years of education, and parents who are not able to become pregnant again after the earthquake being particularly vulnerable.
Kinetic Study of the CCl2 Radical Recombination Reaction by Laser‐Induced Fluorescence Technique
Authors: Gómez Nicolás D. , D'Accurso Violeta , Freytes V. Mariana , Manzano Francisco A. , Codnia Jorge , Azcárate M. Laura 
Published: March 2013

ABSTRACTAn experimental setup that coupled IR multiple‐photon dissociation (IRMPD) and laser‐induced fluorescence (LIF) techniques was implemented to study the kinetics of the recombination reaction of dichlorocarbene radicals, CCl2, in an Ar bath. The CCl2 radicals were generated by IRMPD of CDCl3. The time dependence of the CCl2 radicals’ concentration in the presence of Ar was determined by LIF. The experimental conditions achieved allowed us to associate the decrease in the concentration of radicals to the self‐recombination reaction to form C2Cl4. The rate constant for this reaction was determined in both the falloff and the high‐pressure regimes at room temperature. The values obtained were k0 = (2.23 ± 0.89) × 10−29 cm6 molecules−2 s−1 and k∞ = (6.73 ± 0.23) × 10−13 cm3 molecules−1 s−1, respectively.
Kinetics and Mechanism of the Pyridinolyses of O‐Methyl and O‐Ethyl Phenyl Phosphonochloridothioates in Acetonitrile
Authors: Ul Hoque Md. Ehtesham , Lee Hai Whang 
Published: March 2013

ABSTRACTKinetic studies on the reactions of O‐methyl (2) and O‐ethyl (3) phenyl phosphonochloridothioates with X‐pyridines have been carried out in acetonitrile at 35.0°C. The pyridinolysis rates of 2 are slightly faster than those of 3. The substituent effects of X on the pyridinolysis rates of 2 and 3 are similar. The Hammett and Brönsted plots with X in the nucleophiles are biphasic concave upward with a break point at X = 3‐Ph for both substrates. The stepwise mechanism with rate‐limiting leaving group departure from the intermediate is proposed based on the βX values and biphasic concave upward free energy relationship for both substrates. The biphasic concave upward free energy relationships are rationalized by a frontside nucleophilic attack TSf with more basic pyridines and backside attack TSb with less basic pyridines for both substrates.
Tympanic membrane repair using silk fibroin and acellular collagen scaffolds
Authors: Shen Yi , Redmond Sharon L. , Teh Bing Mei , Yan Sheng , Wang Yan , Atlas Marcus D. , Dilley Rodney J. , Zheng Minghao , Marano Robert J. 
Published: March 2013

Objectives/HypothesisTo evaluate the efficacy of silk fibroin scaffolds (SFS) and acellular collagen scaffolds (ACS) for the repair of tympanic membrane (TM) in a guinea pig acute perforation model.Study DesignExperimental animal research.MethodsSeventy‐two albino guinea pigs underwent perforation of the right TM and were divided into four experimental groups (n = 18). The perforations were repaired with SFS, ACS, and paper patch using onlay myringoplasty, or they were allowed to heal spontaneously (control). An additional group of 10 guinea pigs without perforation or scaffold was allocated as a normal TM group. Guinea pigs in each experimental group (n = 6) were evaluated at 7, 14, and 28 days following surgery. TM structural healing was evaluated by otomicroscopy and histology, and functional hearing was analyzed by auditory brainstem responses (ABR). Prior to the study, mechanical properties of SFS and ACS were investigated.ResultsTensile strength and elasticity of SFS and ACS were within the known range for human TM. Based on otologic and histologic evaluation, TMs treated with SFS or ACS showed complete closure of the perforation at an earlier stage, with a trilaminar structure and more uniform thickness compared to paper patch and control treated groups. ABR assessment demonstrated that SFS or ACS treatment facilitated a faster restoration of hearing function compared to paper patch and control groups.ConclusionThe results of this study show that SFS and ACS are effective graft materials and may be utilized as alternatives to current grafts for TM repair.Level of EvidenceN/A. Laryngoscope, 123:1976–1982, 2013
Bohr's phenomenon for analytic functions and the hyperbolic metric
Authors: Muhanna Yusuf Abu , Ali Rosihan M. 
Published: March 2013

AbstractA link is established between Bohr's inequality for classes of analytic functions and the hyperbolic metric. The classes considered consist of analytic functions mapping the unit disk respectively into the right half‐plane, the slit region, and to the exterior of the unit disk.
The behavior of conditional Wiener integrals on product Wiener space
Authors: Choi Jae Gil , Skouge David , Chang Seung Jun 
Published: March 2013

AbstractIn this paper we first investigate the behavior of conditional Wiener integrals on product Wiener spaces and then proceed to establish a Fubini theorem for conditional Wiener integrals. We then define a very general multiple conditional analytic Fourier‐Feynman transform and a multiple conditional analytic convolution product for functionals on Wiener space and then establish a relationship between them. Next we obtain a basic formula for the conditional Wiener integral involving the first variation and the n‐dimensional Wiener directional derivative. Finally we establish several evaluation formulas for conditional Wiener and Feynman integrals involving the n‐dimensional Wiener directional derivative of functionals on Wiener space.
Access to Intrinsically Glucoside‐Based Microspheres with Boron Affinity
Authors: Vogt Andrew P. , Tischer Thomas , Geckle Udo , Greiner Alexandra M. , Trouillet Vanessa , Kaupp Michael , Barner Leonie , Hofe Thorsten , Barner‐Kowollik Christopher 
Published: March 2013

AbstractIntrinsically glucoside‐based microspheres are prepared in olive oil via a water in oil inverse suspension polymerization. The microspheres are characterized by scanning electron microscopy (SEM), Fourier transform infrared (FTIR) microscopy, and X‐ray photoelectron spectroscopy (XPS), evidencing the intrinsic glucose character of the spheres. A novel boronic acid fluorescent molecule was subsequently conjugated to the microspheres in an aqueous environment, exhibiting the spatial and uniform distribution of glucoside as well as the affinity of the microspheres to bind with boron, evidenced via fluorescence spectroscopy measurements.
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Truncation of type IV pilin induces mucoidy in Pseudomonas aeruginosa strain PAO579
Authors: Ryan Withers T. , Heath Damron F. , Yin Yeshi , Yu Hongwei D. 
Published: March 2013

AbstractPseudomonas aeruginosa is a Gram negative, opportunistic pathogen that uses the overproduction of alginate, a surface polysaccharide, to form biofilms in vivo. Overproduction of alginate, also known as mucoidy, affords the bacterium protection from the host's defenses and facilitates the establishment of chronic lung infections in individuals with cystic fibrosis. Expression of the alginate biosynthetic operon is primarily controlled by the alternative sigma factor AlgU (AlgT/σ22). In a nonmucoid strain, AlgU is sequestered by the transmembrane antisigma factor MucA to the cytoplasmic membrane. AlgU can be released from MucA via regulated intramembrane proteolysis by proteases AlgW and MucP causing the conversion to mucoidy. Pseudomonas aeruginosa strain PAO579, a derivative of the nonmucoid strain PAO1, is mucoid due to an unidentified mutation (muc‐23). Using whole genome sequencing, we identified 16 nonsynonymous and 15 synonymous single nucleotide polymorphisms (SNP). We then identified three tandem single point mutations in the pilA gene (PA4525), as the cause of mucoidy in PAO579. These tandem mutations generate a premature stop codon resulting in a truncated version of PilA (PilA108), with a C‐terminal motif of phenylalanine‐threonine‐phenylalanine (FTF). Inactivation of pilA108 confirmed it was required for mucoidy. Additionally, algW and algU were also required for mucoidy of PAO579. Western blot analysis indicated that MucA was less stable in PAO579 than nonmucoid PAO1 or PAO381. The mucoid phenotype and high PalgU and PalgD promoter activities of PAO579 require pilA108, algW, algU, and rpoN encoding the alternative sigma factor σ54. We also observed that RpoN regulates expression of algW and pilA in PAO579. Together, these results suggest that truncation in type IV pilin in P. aeruginosa strain PAO579 can induce mucoidy through an AlgW/AlgU‐dependent pathway.
The VPS35 gene and Parkinson's disease
Authors: Deng Hao , Gao Kai , Jankovic Joseph 
Published: March 2013

ABSTRACTParkinson's disease (PD), the second most common age‐related neurodegenerative disease, is characterized by loss of dopaminergic and nondopaminergic neurons, leading to a variety of motor and nonmotor symptoms. In addition to environmental factors, genetic predisposition and specific gene mutations have been shown to play an important role in the pathogenesis of this disorder. Recently, the identification of the vacuolar protein sorting 35 homolog gene (VPS35), linked to autosomal dominant late‐onset PD, has provided new clues to the pathogenesis of PD. Here we discuss the VPS35 gene, its protein function, and various pathways involved in Wnt/β‐catenin signaling and in the role of DMT1 mediating the uptake of iron and iron translocation from endosomes to the cytoplasm. Further understanding of these mechanisms will undoubtedly provide new insights into the pathogenic mechanisms of PD and may lead to prevention and better treatment of the disorder. © 2013 Movement Disorder Society
Biochemical phenotype of a common disease‐causing mutation and a possible therapeutic approach for the phosphomannomutase 2‐associated disorder of glycosylation
Authors: Andreotti Giuseppina , Pedone Emilia , Giordano Assunta , Cubellis Maria Vittoria 
Published: March 2013

AbstractPhosphomannomutase 2 (PMM2) deficiency represents the most frequent type of congenital disorders of glycosylation. For this disease there is no cure at present. The complete loss of phosphomannomutase activity is probably not compatible with life and people affected carry at least one allele with residual activity. We characterized wild‐type PMM2 and its most common hypomorphic mutant, p.F119L, which is associated with a severe phenotype of the disease. We demonstrated that active species is the dimeric enzyme and that the mutation weakens the quaternary structure and, at the same time, affects the activity and the stability of the enzyme. We demonstrated that ligand binding stabilizes both proteins, wild‐type and F119L‐PMM2, and promotes subunit association in vitro. The strongest effects are observed with glucose‐1,6‐bisphosphate (Glc‐1,6‐P2) or with monophosphate glucose in the presence of vanadate. This finding offers a new approach for the treatment of PMM2 deficiency. We propose to enhance Glc‐1,6‐P2 concentration either acting on the metabolic pathways that control its synthesis and degradation or exploiting prodrugs that are able to cross membranes.
Broadband antenna with capacitive‐coupling for mobile handsets
Authors: Yoon Cheol , Hwang Sun‐Gook , Lee Gi‐Chan , kim Woo‐Su , Lee Hwa‐Choon , Park Hyo‐Dal 
Published: March 2013

AbstractIn this article, a broadband antenna for LTE, GSM, DCS, PCS, and WCDMA is proposed.The antenna consists of a T‐shape strip and a shorted strip with capacitive coupling is excited. The capacitively coupled shorted strip shows resonance at the lower band, and the T‐shape strip presents good matching at the higher band because the characteristics of input impedance are affected by the coupling. Moreover, by optimizing the dimensions of the L‐shape strip, the total bandwidth of the antenna can be greatly improved. © 2013 Wiley Periodicals, Inc. Microwave Opt Technol Lett 55:1308–1312, 2013; View this article online at wileyonlinelibrary.com. DOI 10.1002/mop.27532