bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cerebrospinal fluid amyloid-β 42/40 ratio in clinical setting of memory centers: a multicentric study
Authors: Dumurgier Julien , Schraen Susanna , Gabelle Audrey , Vercruysse Olivier , Bombois Stéphanie , Laplanche Jean-Louis , Peoc’h Katell , Sablonnière Bernard , Kastanenka Ksenia V , Delaby Constance , Pasquier Florence , Touchon Jacques , Hugon Jacques , Paquet Claire , Lehmann Sylvain 
Published: March 2015

Abstract
Introduction
The cerebrospinal fluid (CSF) biomarkers amyloid-β (Aβ), tau and phosphorylated tau (p-tau181) are now used for the diagnosis of Alzheimer’s disease (AD). Aβ40 is the most abundant Aβ peptide isoform in the CSF, and the Aβ 42/40 ratio has been proposed to better reflect brain amyloid production. However, its additional value in the clinical setting remains uncertain.

Methods
A total of 367 subjects with cognitive disorders who underwent a lumbar puncture were prospectively included at three French memory centers (Paris-North, Lille and Montpellier; the PLM Study). The frequency of positive, negative and indeterminate CSF profiles were assessed by various methods, and their adequacies with the diagnosis of clinicians were tested using net reclassification improvement (NRI) analyses.

Results
On the basis of local optimum cutoffs for Aβ42 and p-tau181, 22% of the explored patients had indeterminate CSF profiles. The systematic use of Aβ 42/40 ratio instead of Aβ42 levels alone decreased the number of indeterminate profiles (17%; P = 0.03), but it failed to improve the classification of subjects (NRI = −2.1%; P = 0.64). In contrast, the use of Aβ 42/40 ratio instead of Aβ42 levels alone in patients with a discrepancy between p-tau181 and Aβ42 led to a reduction by half of the number of indeterminate profiles (10%; P < 0.001) and was further in agreement with clinician diagnosis (NRI = 10.5%; P = 0.003).

Conclusions
In patients with a discrepancy between CSF p-tau181 and CSF Aβ42, the assessment of Aβ 42/40 ratio led to a reliable biological conclusion in over 50% of cases that agreed with a clinician’s diagnosis.
Kidney disease as a determinant of cognitive decline and dementia
Authors: Etgen Thorleif 
Published: March 2015

AbstractChronic kidney disease (CKD) has evolved as a possible new determinant of cognitive decline and dementia. This review outlines the presumed pathophysiology of cognitive decline in CKD, which consists of traditional and new vascular risk factors as well as nonvascular risk factors and metabolic and biochemical abnormalities within the central nervous system caused by CKD. The recent major cross-sectional studies and longitudinal studies – including one meta-analysis – that mostly suggest an association of cognitive decline and CKD are discussed. Finally, potential therapeutic strategies are presented.
Selective spectrofluorimetric method for the determination of perindopril erbumine in bulk and tablets through derivatization with dansyl chloride
Authors: Sakur Amir Alhaj , Chalati Tamim , Fael Hanan 
Published: March 2015

Abstract

Background
Perindopril erbumine is an antihypertensive, which belongs to the category of angiotensin-converting enzyme inhibitors (ACE inhibitors) that inhibit the conversion of angiotensin I to angiotensin II.

Methods
A new, selective, and sensitive spectrofluorimetric method was developed for the determination of perindopril erbumine based on the reaction with dansyl chloride in alkaline medium to give a highly fluorescent derivative which was measured at 496 nm after excitation at 340 nm in dichloromethane. The reaction conditions were studied and optimized.

Results
Under the optimum conditions, the fluorescence intensity was linear over a concentration range of 1.0 to 21.0 μg/mL (R
2 = 0.9997) with a detection limit of 0.242 μg/mL. In order to validate the method, the results were compared with those obtained by a high performance liquid chromatography method.

Conclusions
The proposed method was successfully applied to the analysis of perindopril erbumine in pure form and tablets with good precision and accuracy as revealed by t- and F tests. The mechanism of the reaction has also been discussed.
Naringenin Prevents Obesity, Hepatic Steatosis, and Glucose Intolerance in Male Mice Independent of Fibroblast Growth Factor 21
Authors: Assini Julia M. , Mulvihill Erin E. , Burke Amy C. , Sutherland Brian G. , Telford Dawn E. , Chhoker Sanjiv S. , Sawyez Cynthia G. , Drangova Maria , Adams Andrew C. , Kharitonenkov Alexei , Pin Christopher L. , Huff Murray W. 
Published: March 2015

Abstract
The molecular mechanisms and metabolic pathways whereby the citrus flavonoid, naringenin, reduces dyslipidemia and improves glucose tolerance were investigated in C57BL6/J wild-type mice and fibroblast growth factor 21 (FGF21) null (Fgf21−/−) mice. FGF21 regulates energy homeostasis and the metabolic adaptation to fasting. One avenue of this regulation is through induction of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc1a), a regulator of hepatic fatty acid oxidation and ketogenesis. Because naringenin is a potent activator of hepatic FA oxidation, we hypothesized that induction of FGF21 might be an integral part of naringenin's mechanism of action. Furthermore, we predicted that FGF21 deficiency would potentiate high-fat diet (HFD)-induced metabolic dysregulation and compromise metabolic protection by naringenin. The absence of FGF21 exacerbated the response to a HFD. Interestingly, naringenin supplementation to the HFD robustly prevented obesity in both genotypes. Gene expression analysis suggested that naringenin was not primarily targeting fatty acid metabolism in white adipose tissue. Naringenin corrected hepatic triglyceride concentrations and normalized hepatic expression of Pgc1a, Cpt1a, and Srebf1c in both wild-type and Fgf21−/− mice. HFD-fed Fgf21−/− mice displayed greater muscle triglyceride deposition, hyperinsulinemia, and impaired glucose tolerance as compared with wild-type mice, confirming the role of FGF21 in insulin sensitivity; however, naringenin supplementation improved these metabolic parameters in both genotypes. We conclude that FGF21 deficiency exacerbates HFD-induced obesity, hepatic steatosis, and insulin resistance. Furthermore, FGF21 is not required for naringenin to protect mice from HFD-induced metabolic dysregulation. Collectively these studies support the concept that naringenin has potent lipid-lowering effects and may act as an insulin sensitizer in vivo.
Relationship of Pathologic Factors to Efficacy of Sorafenib Treatment in Patients With Metastatic Clear Cell Renal Cell Carcinoma
Authors: Araki Hidemori , Tsuzuki Toyonori , Kimura Tohru , Tanaka Kuniaki , Yamada Shin , Sassa Naoto , Yoshino Yasushi , Hattori Ryohei , Gotoh Momokazu 
Published: March 2015

Abstract

Objectives:
To evaluate the predictive value of growth patterns in patients undergoing sorafenib treatment for metastatic clear cell renal cell carcinomas (CCRCCs).

Methods:
Forty-eight patients were analyzed, each of whom underwent nephrectomy and received sorafenib treatment for metastatic CCRCC. Progression-free survival (PFS) was predicted using pathologic parameters, including pathologic stage, Fuhrman nuclear grade (FNG), the presence of a sarcomatoid component, lymphovascular invasion, tumor necrosis, and growth pattern.

Results:
Three (6%) patients showed partial response, 20 (42%) patients showed stable disease, and 25 (52%) patients showed progressive disease. Univariate analyses demonstrated that FNG, the presence of a sarcomatoid component, tumor necrosis, and growth pattern were significantly associated with PFS. In the multivariate analysis, growth pattern was the only parameter that was significantly and independently predictive of PFS.

Conclusions:
As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment.
Primary Sclerosing Cholangitis
Authors: Carrasco-Avino Gonzalo , Schiano Thomas D. , Ward Stephen C. , Thung Swan N. , Fiel M. Isabel 
Published: March 2015

AbstractObjectives:Liver biopsy diagnosis of primary sclerosing cholangitis (PSC) is difficult. We performed a detailed histologic analysis of PSC cases using novel bioinformatics analysis to identify histologic features that may be useful in its diagnosis.Methods:PSC liver explants were examined and compared with primary biliary cirrhosis and hepatitis C explants to act as controls. Demographic, macroscopic, and histologic variables were analyzed using both conventional statistics and an integrative bioinformatics approach, significance analysis of microarrays (SAM), and hierarchical clustering analysis (HCA).Results:The PSC group was younger and had distinctive PSC features, including bile duct scars, onion-skin fibrosis, and arterial fibrointimal hyperplasia. SAM allowed the integration of variables by comparing PSC and control groups, whereas HCA was able to correctly categorize each group.Conclusions:This study demonstrates characteristic PSC histology as well as arterial hyperplasia to be distinctive features that may aid in PSC diagnosis and be confirmed by bioinformatics.
The francophone media in Belgium: A question of identity
Authors: Lits Marc 
Published: March 2015

Abstract
In Belgium, the political and linguistic divisions make problematic the assertion of a national or regional identity. The political evolution entailed a quadruple division of the media: linguistics; public channels versus private; local channels versus national; and national versus foreign countries. In this context, Flanders became a foreign ground for the French speakers, and the opposite is also true. When a subject is treated, it is as if it was about foreign policy, with simplifications, by resorting to stereotypes.
Taken in these intercommunity cleavages, the Belgian media reveal more of the identity crisis of a country near the separatism than they build a strong identity. The media work as relays of their respective public opinions. That raises the question of the role of media belonging to different linguistic areas but living in the same political entity, and their difficulty to find a balance between defense of the interests of their community and relation distanced from the national stakes.
Analytic Error Assessment of Gyro-Free INS
Authors: Klein Itzik 
Published: March 2015

AbstractAgyro-free INS consists of at least six distributed accelerometers capable of obtaining linear and angular acceleration and thereby capable of functioning as a conventional INS. Most of the research in the gyro-free field focused on seeking optimal accelerometer configurations and less attention was given to deriving appropriate statespace models and analytical error assessment as in a conventional INS.In this paper, we aim to fill this gap by contributing to three aspects of gyro-free theory. Firstly, practical gyrofree kinematic equations of motion and corresponding error-state models fitting to any set of accelerometers configuration are derived. Secondly, an analytic error assessment of the North Channel dynamics is provided enabling insight on the parameters affecting the gyro-free INS position error. Thirdly, a comparison between INS and gyrofree INS is performed, based on the derived analytical expressions.
Experimental and Non-Experimental Methods in Development Economics: A Porous Dialectic
Authors: Dehejia Rajeev 
Published: March 2015

AbstractThis paper surveys six widely-used non-experimental methods for estimating treatment effects (instrumental variables, regression discontinuity, direct matching, propensity score matching, linear regression and non-parametric methods, and difference-in-differences), and assesses their internal and external validity relative both to each other and to randomized controlled trials. While randomized controlled trials can achieve the highest degree of internal validity when cleanly implemented in the field, the availability of large, nationally representative data sets offers the opportunity for a high degree of external validity using non-experimental methods. We argue that each method has merits in some context and they are complements rather than substitutes.
Analytical Evaluation of Bit Error Rate Performance of a Free-Space Optical Communication System with Receive Diversity Impaired by Pointing Error
Authors: Nazrul Islam A. K. M. , Majumder S. P. 
Published: March 2015

AbstractAnalysis is carried out to evaluate the conditional bit error rate conditioned on a given value of pointing error for a Free Space Optical (FSO) link with multiple receivers using Equal Gain Combining (EGC). The probability density function (pdf) of output signal to noise ratio (SNR) is also derived in presence of pointing error with EGC. The average BER of a SISO and SIMO FSO links are analytically evaluated by averaging the conditional BER over the pdf of the output SNR. The BER performance results are evaluated for several values of pointing jitter parameters and number of IM/DD receivers. The results show that, the FSO system suffers significant power penalty due to pointing error and can be reduced by increasing in the number of receivers at a given value of pointing error. The improvement of receiver sensitivity over SISO is about 4 dB and 9 dB when the number of photodetector is 2 and 4 at a BER of 10
Crystal structure of (μ2-acetato-κ2O,O’)-(μ2-bromido)-(μ2-oxido)-tetrabromido- triphenylphosphane-κP-triphenylphosphaneoxide-κOdirhenium( IV)), C38H33Br5O4P2Re2
Authors: Mukiza Janvier , Gerber Thomas I. A. , Hosten Eric C. , Betz Richard 
Published: March 2015

Abstract C38H33Br5O4P2Re2, triclinic, P1̄ (no. 2), a = 10.7759(5) Å, b = 13.4635(6) Å, c = 14.7580(7) Å, α = 93.642(2)°, β = 108.372(2)°, γ = 91.303(2)°, V = 2025.8 Å3, Z = 2, Rgt(F) = 0.0207, wRref(F2) = 0.0492, T = 200 K.
Crystal structure of 5-di-tert-butylphosphinoyl-25,26,27,28-tetrabenzoyloxy- calix[4]arene – dichloromethane (1:1), C64H65O5P – CH2Cl2, C65H67Cl2O5P
Authors: Elaieb Fethi , Sémeril David , Matt Dominique , Hedhli Ahmed 
Published: March 2015

Abstract C65H67Cl2O5P, monoclinic, P21/c (no. 14), a = 16.118(1) Å, b = 10.0843(7) Å, c = 35.113(2) Å, β = 104.009(3)°, V = 5537.5 Å3, Z = 4, Rgt(F) = 0.0930, wRref(F2) = 0.1855, T = 173 K.
Crystal structure of tricarbonyl-chlorido-(2E)-2-(6-(E-(2-hydroxyphenylimino) methyl)pyridine-2-yl)methyleneaminophenol-rhenium(I), C22H15ClN3O5Re
Authors: Habarurema Gratien , Gerber Thomas I. A. , Hosten Eric C. , Betz Richard 
Published: March 2015

Abstract C22H15ClN3O5Re, monoclinic, P21/c (no. 14), a = 13.1731(4) Å, b = 10.6615(3) Å, c = 16.7609(5) Å, β = 112.546(1)°, V = 2174.1 Å3, Z = 4, Rgt(F) = 0.0177, wRref(F2) = 0.0381, T = 200 K.
Efficient synthesis of 2,3-dimethoxy-5-methyl-6-morpholinomethyl-1,4-benzoquinone hydrochloride
Authors: Wang Jin , Liao Teng-huo-sheng , Yang Jian 
Published: March 2015

Abstract
The title compound (5) was prepared by a reaction sequence starting from 2,3,4,5-tetramethoxytoluene (1) via the Blanc reaction, oxidation and alkylation. The described method provides a good yield of the C-6 heterocyclic-substituted benzoquinone derivative and is suitable for the synthesis of other benzoquinone derivatives.
A Powerful New Quantitative Genetics Platform, CombiningCaenorhabditis elegansHigh-Throughput Fitness Assays with a Large Collection of Recombinant Strains
Authors: Andersen Erik C , Shimko Tyler C , Crissman Jonathan R , Ghosh Rajarshi , Bloom Joshua S , Seidel Hannah S , Gerke Justin P , Kruglyak Leonid 
Published: March 2015

AbstractThe genetic variants underlying complex traits are often elusive even in powerful model organisms such as Caenorhabditis elegans with controlled genetic backgrounds and environmental conditions. Two major contributing factors are: (1) the lack of statistical power from measuring the phenotypes of small numbers of individuals, and (2) the use of phenotyping platforms that do not scale to hundreds of individuals and are prone to noisy measurements. Here, we generated a new resource of 359 recombinant inbred strains that augments the existing C. elegans N2xCB4856 recombinant inbred advanced intercross line population. This new strain collection removes variation in the neuropeptide receptor gene npr-1, known to have large physiological and behavioral effects on C. elegans and mitigates the hybrid strain incompatibility caused by zeel-1 and peel-1, allowing for identification of quantitative trait loci that otherwise would have been masked by those effects. Additionally, we optimized highly scalable and accurate high-throughput assays of fecundity and body size using the COPAS BIOSORT large particle nematode sorter. Using these assays, we identified quantitative trait loci involved in fecundity and growth under normal growth conditions and after exposure to the herbicide paraquat, including independent genetic loci that regulate different stages of larval growth. Our results offer a powerful platform for the discovery of the genetic variants that control differences in responses to drugs, other aqueous compounds, bacterial foods, and pathogenic stresses.
Simulation of corn (Zea mays L.) production in different agricultural zones of Colombia using the AquaCrop model
Authors: García Á. Javier , Riaño H. Nestor , Magnitskiy Stanislav 
Published: March 2015

Due to climate changes and increasing food needs, it is important to develop simple models of wide application to determine the irrigation needs. The aim of this study was to calibrate and validate the AquaCrop model in maize crop of the variety ICA V156 in different locations of Colombia, such as Chinchina (Caldas), Palmira (Valle del Cauca) and Cerete (Cordoba), situated at altitudes of 20, 900, and 1,340 m a.s.l., respectively. As part of the model calibration, the biomass, harvest index, and grain yield were recorded. After the calibration, the Pearson correlation coefficient and the respective analysis of variance were calculated for each variable. The biomass, harvest index and grain yield were different in each study site, with the highest grain obtained in Cerete, followed by Chinchina and, finally, Palmira. The modeling in each of the locations showed similarity between the field data and the simulated data in each of the sites. In the calibration, Palmira had the highest grain yield (4.9 t ha-1), followed by Chinchina (4.83 t ha-1) and Cerete (4.15 t ha-1). The validation in each location allowed for the determination of the grain yield, harvest index, biomass and the amount of water needed for crop growth, which averaged 3.45 kg of biomass per m3 of evapotranspired water and was reflected in an average yield of 1.26 kg of grain per m3 of evapotranspired water.
Thermal and in vitro evaluation of a composite material pHEMA/Chitosan/Hydroxyapatite
Authors: Salgado-Delgado Areli.M. , Vargas-Galarza Zully , Salgado-Delgado René , Rubio-Rosas Efraín , García-Hernández Edgar , Hernández-Díaz Wendy. N. 
Published: March 2015

ABSTRACTBioactive materials based on polymer/hydroxyapatite are currently being extensively investigated as materials for promotion of bone tissue regeneration and reconstruction [1]. In this work, a material interpenetrating based on poly 2-hydroxyethyl methacrylate (pHEMA), Chitosan and hydroxyapatite (HA) was prepared following the methodology of the foaming gas Damla Çetin [2], generating an interpenetrated network with the chitosan filled with hydroxyapatite. The materials were evaluated by thermal gravimetric analysis (TGA) and in vitro bioactivity [3] (SBF) and characterized by using scanning electron microscopy (SEM). The TGA studies suggested that there was not existence of possible interactions between polymers and HA but there is a thermal stability increase in the HA content. Meanwhile, SBF and its characterization by SEM, was found that the materials are bioactives as indicated by the formation of a bone-like apatite layer after immersion in simulated body ﬂuid, indicating the potential of this material for use in bone tissue engineering.
The Direct Measurement of Ionic Piezoresistance
Authors: Cook Stuart N. , Tuller Harry L. 
Published: March 2015

ABSTRACTIonic piezoresistance, the effect of lattice strain on ionic conductivity, is an important concept that needs to be harnessed to engineer the next generation of fast ionic conductors. To date there have been many reports of strain affecting changes in the level of ionic conductivity in solid electrolytes. The fundamental understanding is, however, still lacking, with limited experimental quantification of the magnitude of the effect. Here, we propose using the ionic piezoresistive coefficient, the constant of proportionality between the strain state and the change in conductivity, as a quantitative measure of this effect and detail a novel technique we have developed to quantify this in high temperature ionically conducting materials.
Foams Stabilized by In-Situ Surface-Activated Nanoparticles in Bulk and Porous Media
Authors: Singh Robin , Mohanty Kishore K. 
Published: March 2015

Summary
Foams for subsurface applications are traditionally stabilized by surfactants. The goal of this work is to study foam stabilization by nanoparticles—in particular, by in-situ surface-hydrophobization of hydrophilic nanoparticles. The interfacial properties of the nanoparticles were modulated by the attachment of short-chain surface modifiers (alkyl gallates) that render them partially hydrophobic, but still fully dispersible in water. First, static foams were generated with nanoparticles with varying concentrations of surface modifiers. The decay of foam height with time was measured, and half-lives were determined. Optical micrographs of foam stabilized by surface-modified nanoparticles (SMNPs) and surfactant were recorded. Second, aqueous foams were created in-situ by coinjecting the SMNP solutions with nitrogen gas through a Berea sandstone core at a fixed quality. Pressure drop across the core was measured to estimate the achieved resistance factor. These pressure-drop results were then compared with those of a typical surfactant (alpha olefin sulfonate, alkyl polyglucoside) under similar conditions. Finally, oil-displacement experiments were conducted in Berea cores with surfactant and SMNP solutions as foaming agents (coinjection with nitrogen gas). A Bartsch shake test revealed the strong foaming tendency of SMNPs even with a very low initial surface-modifier concentration (0.05 wt%), whereas hydrophilic nanoparticles alone could not stabilize foam. The bubble texture of foam stabilized by SMNPs was finer than that with surfactants, indicating a stronger foam. As the degree of surface coating increased, the resistance factor of SMNP foam in a Berea core increased significantly. The corefloods in the sandstone cores with a reservoir crude oil showed that immiscible foams with SMNP solution can recover a significant amount of oil (20.6% of original oil in place) over waterfloods.