bluuebunny/crossref_metadata_2025_split huggingface dataset:
Isolated limb perfusion using tumour necrosis factor α and melphalan in patients with advanced aggressive fibromatosis
Authors: van Broekhoven D L M , Deroose J P , Bonvalot S , Gronchi A , Grünhagen D J , Eggermont A M M , Verhoef C 
Published: October 2014

Abstract

Background
Aggressive fibromatoses (desmoid tumours) may be locally aggressive, but do not metastasize. Although a conservative approach is advocated for most patients, pain and functional impairment are indications for active treatment. Tumour necrosis factor (TNF) α and melphalan-based isolated limb perfusion (TM-ILP) is a limb-saving treatment modality for soft tissue tumours. This study reports the results of TM-ILP treatment in patients with aggressive fibromatosis.

Methods
Institutional databases of three European centres were searched. All patients who received TM-ILP treatment for aggressive fibromatosis between 1990 and 2012 were included. Before therapy, the patients were discussed at multidisciplinary tumour board meetings.

Results
Twenty-five patients received 28 TM-ILP treatments. The median age of patients was 28 (i.q.r. 19–34) years and median hospital stay was 8 (7–12) days. Median follow-up was 84 (34–114) months. A complete response was achieved after two TM-ILP treatments, and a partial response after 17 treatments in 16 patients. Stable disease was reported after eight treatments in seven patients, including a patient with stable disease after the first treatment and progression after the second TM-ILP. Toxicity was modest after most treatments; Wieberdink grade IV (extensive epidermolysis, and threatening or manifest compartment syndrome) was seen after two TM-ILP treatments. Systemic leakage was reported after one treatment, but did not lead to systemic toxicity. Functional outcome was good; 16 patients had no physical limitations, and six patients had some limitations but did not need medical aids. Amputation was prevented in all but three patients.

Conclusion
TNF-α-based ILP is effective in patients with aggressive fibromatosis.
A retrospective analysis of cross‐reacting cetuximab IgE antibody and its association with severe infusion reactions
Authors: Maier Sabine , Chung Christine H. , Morse Michael , Platts‐Mills Thomas , Townes Leigh , Mukhopadhyay Pralay , Bhagavatheeswaran Prabhu , Racenberg Jan , Trifan Ovidiu C. 
Published: October 2014

AbstractSevere infusion reactions (SIRs) at rates of 5% or less are known side effects of biological agents, including mAbs such as cetuximab. There are currently no prospectively validated risk factors to aid physicians in identifying patients who may be at risk of experiencing an SIR following administration of any of these drugs. A retrospective analysis of 545 banked serum or plasma samples from cancer patients participating in clinical trials of cetuximab was designed to evaluate whether the presence of pretreatment IgE antibodies against cetuximab, as determined by a commercially available assay system, is associated with SIRs during the initial cetuximab infusion. Patients with a positive test indicating the presence of pretreatment antibodies had a higher risk of experiencing an SIR; however, at the prespecified cutoff utilized in this analysis, the test has a relatively low‐positive predictive value (0.577 [0.369–0.766]) and a negative predictive value of 0.961 (0.912–0.987) in an unselected patient population. Data collected in this large retrospective validation study support prior observations of an association between the presence of pretreatment IgE antibodies cross‐reactive with cetuximab and SIRs. Further analysis of the test's ability to predict patients at risk of an SIR would be required before this assay could be used reliably in this patient population.
‘An Association for All’—Notions of the Meaning of Autistic Self‐Advocacy Politics within a Parent‐Dominated Autistic Movement
Authors: Bertilsdotter Rosqvist Hanna , Brownlow Charlotte , O'Dell Lindsay 
Published: October 2014

AbstractIn this paper, we seek to explore the tensions between advocacy and self advocacy autistic movements in a Swedish context with a special focus on the meanings that enable the production of particular understandings of autism and the autistic subject. Drawing on articles written for the Swedish advocacy magazine Empowerment written for and by people with autism, the discourse analysis explores two competing discourses: a reformist and a radical. The reformist discourse underlines a goal of (political) representation expressed in Empowerment. It may be understood as an important part of producing a legitimate autistic political subject–positioned as a full member, with a full membership–within a parent‐dominated autistic advocacy movement. The reformist discourse can be viewed as a result of a negotiation, where full membership is conditioned on the parents' terms and granted on specific terms. These include working together (neuro‐inclusively), advocacy based on interest rather than identity/position as a specific target/member group, agreement upon a definition of autism as a disability (a deficit) a person has rather than an identity. In relation to this, an alternative legitimate autistic subject is produced through invoking the counter‐hegemonic radical discourse. Such a narrative produces the ‘Asperger’ or ‘Aspie’. Here, the ‘full membership’ refers to a sense of identification with sense of belonging to and being at home with other people with autism. It contains a certain amount of autistic solidarity within the group of adults with autism. Copyright © 2014 John Wiley & Sons, Ltd.
The Community Psychologist as Critical Friend: Promoting Critical Community Praxis
Authors: Evans Scotney D. 
Published: October 2014

AbstractCommunity‐engaged researchers have a responsibility to community partners to get beyond the traditional researcher stance to take on the active role of critical friend. On the basis of my own community research experiences in the USA, in this article, I argue that there is added value in taking on the practice of critical friendship to encourage a higher degree of critical reflection and critical practice in our partners and in our work together. In the context of long‐term, trusting relationships with community partners, researchers can play the role of critical friend working together to shape critical community praxis on the basis of critical theorizing, critical reflection, and a shared commitment to working for social justice. Those trying to make a difference in communities are often isolated and can benefit from opportunities for dialogue with other community practitioners within a critical frame of reference. Although not without risks and challenges, stepping into this role allows us to put into sharper relief the gap between community practice that challenges injustice and practice that maintains it. Copyright © 2014 John Wiley & Sons, Ltd.
Towards Multifunctional Materials Incorporating Elastomers and Reversible Redox‐Active Fragments
Authors: Tarrés Màrius , Viñas Clara , Cioran Ana M. , Hänninen Mikko M. , Sillanpää Reijo , Teixidor Francesc 
Published: October 2014

AbstractThis paper presents a novel and unique feature of metallacarboranes, consisting of the linkage of this redox electro‐active site to a stretchable polymer. This is based on polyTHF, a known and applied material. This hybrid material has the two ends functionalized: one with the aforementioned redox molecule and the other with a terminal OH group, both linked by a molecular spring. Moreover, the redox electro‐active molecules can be synthesized with either cobalt (cobaltabisdicarbollide) or with iron (ferrabisdicarbollide), species whose respective E1/2 value differs by almost 1 V. The polymerization mechanism, based on an intermediate molecular crystal structure, is explained through an unexpected cyclization process of the dioxanate derivative of the metallacarboranes with an additional THF molecule. This is achieved in the absence of any metal or external electrophile. Surface functionalization of a Pt electrode by the electropolymerization of pyrrole doped with the pristine metallacarboranes and with the polyTHF hybrid materials is reported in this paper.
Restriction of Intramolecular Motions: The General Mechanism behind Aggregation‐Induced Emission
Authors: Leung Nelson L. C. , Xie Ni , Yuan Wangzhang , Liu Yang , Wu Qunyan , Peng Qian , Miao Qian , Lam Jacky W. Y. , Tang Ben Zhong 
Published: October 2014

AbstractAggregation‐induced emission (AIE) has been harnessed in many systems through the principle of restriction of intramolecular rotations (RIR) based on mechanistic understanding from archetypal AIE molecules such as tetraphenylethene (TPE). However, as the family of AIE‐active molecules grows, the RIR model cannot fully explain some AIE phenomena. Here, we report a broadening of the AIE mechanism through analysis of 10,10′,11,11′‐tetrahydro‐5,5′‐bidibenzo[a,d][7]annulenylidene (THBDBA), and 5,5′‐bidibenzo[a,d][7]annulenylidene (BDBA). Analyses of the computational QM/MM model reveal that the novel mechanism behind the AIE of THBDBA and BDBA is the restriction of intramolecular vibration (RIV). A more generalized mechanistic understanding of AIE results by combining RIR and RIV into the principle of restriction of intramolecular motions (RIM).
One‐Step Double Covalent Functionalization of Reduced Graphene Oxide with Xanthates and Peroxides
Authors: Pennetreau Florence , Riant Olivier , Hermans Sophie 
Published: October 2014

AbstractRadical functionalization of reduced graphene oxide has been achieved by reaction with a xanthate in the presence of peroxide as a radical initiator. X‐ray photoelectron spectroscopy, bulk elemental analyses, and thermogravimetric analyses showed that the xanthate grafting is covalent and efficient. The synthesis and use of seven xanthates and three peroxides showed that the highest grafting yield is obtained when xanthate and peroxide are introduced in stoichiometric amounts. It also revealed that the peroxide used as radical initiator is grafted at the graphenic surface during the functionalization. The method presented in this contribution therefore allows bifunctionalized reduced graphene oxide samples to be easily obtained in one single step. This method leads to undamaged graphene sheets with higher dispersibility than the pristine sample.
Chemoinformatik
Authors: Engel Thomas 
Published: October 2014

AbstractDieser Artikel ermöglicht einen ersten Einblick in das faszinierende Gebiet und die Vielzahl der eingesetzten Methoden der Chemoinformatik. Leider mussten aus Platzgründen weitere interessante Bereiche ausgespart bleiben, z.B. das Molecular Modelling [13] oder die Chemometrie [14]. Dennoch ist ersichtlich, dass Methoden der Chemoinformatik in viele Bereiche der Chemie Einzug gehalten haben, von der Analytischen Chemie über Materialforschung bis hin zur Wirkstoffforschung, und dort wesentliche Beiträge leisten. Im Mittelpunkt steht hierbei immer die chemische Information der Moleküle, welche erzeugt, organisiert, verwaltet, suchbar gemacht, analysiert und visualisiert werden muss.
Eine haarige Angelegenheit
Authors: Feil Sylvia 
Published: October 2014

AbstractObwohl haarige Zellfortsätze, sogenannte Flimmerhärchen oder Zilien, schon lange bekannt sind, ist noch recht unerforscht, wie ihr Zusammenbau bei der Differenzierung von Zellen gesteuert wird. Für die Flimmerhärchen auf dem Epithel von Lunge und Luftröhre spielen offenbar sechs Mikro‐RNAs in diesem Prozess eine Schlüsselrolle [1].
Einfacher Weg zu Chromanol‐Antioxidantien
Authors: Jaenicke Lothar 
Published: October 2014

AbstractTocopherole sind natürliche fettlösliche, äußerst wirksame Bio‐Antioxidantien, hilfreich gegen die in unserem aeroben Lebensraum überall vorhandenen reaktiven, äußerst toxischen, freien Sauerstoffradikale (ROS). Sie werden daher vielfach in der Lebensmittelindustrie eingesetzt. Allerdings ist ihre Synthese teuer und aufwendig. Basis für einen einfacheren Zugang könnte eine neue Synthese zu 6‐Chromanolen sein [1].
Optimum solution of the CIECAM02 yellow–blue and purple problems
Authors: Jiang Jun , Wang Zhifeng , Luo M. Ronnier , Melgosa Manuel , Brill Michael H. , Li Changjun 
Published: October 2014

AbstractBrill [Color Res Appl 2006;31:142‐145] and Brill and Süsstrunk [Color Res Appl 2008;33:424‐426] found that CIECAM02 has the yellow–blue and purple problems and gave partial solutions to them. In this article we model the optimum solution to the yellow–blue and purple problems simultaneously as a constrained non‐linear optimization problem. An optimum solution resulting in a new CAT02 matrix is numerically obtained. This new matrix satisfies the nesting rule and performs better than the Hunt‐Pointer‐Estévez (HPE) matrix in predicting both corresponding colours and colour appearance data sets. Specifically, it was found that the new and HPE matrices performed significantly different on nine (out of 21) corresponding colour data sets and on all corresponding colours data sets as a whole. © 2014 Wiley Periodicals, Inc. Col Res Appl, 40, 491–503, 2015
Twinning in GaAs nanowires on patterned GaAs(111)B
Authors: Walther Thomas , Krysa Andrey B. 
Published: October 2014

We have studied twinning in GaAs nanowires grown via holes in a silica mask deposited on GaAs(111)B substrates by metal‐organic chemical vapour epitaxy without catalysts. Twins perpendicular to the growth direction form in the nanowires, their {111}‐type side facets leading to corrugation of their {110} side walls. The top facets are almost atomically smooth. Aberration corrected annular dark‐field scanning transmission electron microscopy reveals all twins are rotational, commencing with layers of Ga and finishing with As atoms. Energy‐loss spectroscopic profiling has shown no significant changes in the band‐gap or bulk plasmon energy at those twin boundaries, and the observed reduction of the interface plasmon energy by ∼0.13 eV is close to the detection limit of the technique, reflecting the very low energetic electronic changes related to twin formation.
Low‐complexity joint detection of carrier frequency offset and sector cell index for LTE cellular system
Authors: Kim Byung‐Kyu , Song Hyoung‐Kyu , You Young‐Hwan 
Published: October 2014

SummaryIn this paper, we propose a low‐complexity joint detection of sector cell index and integer carrier frequency offset for a long‐term evolution downlink system. In order to implement a low‐cost detection scheme, a primary synchronization signal used for joint parameter estimation is grouped into a number of subsets so that the pilots in each subset are strongly correlated. The estimation performance and the computational load of the proposed scheme are compared with those of the commonly used conventional detection scheme using a differential correlation to remove common channel effects. It is found that the proposed scheme can jointly detect the cell index and integer carrier frequency offset with higher accuracy and much lower complexity, compared with the conventional scheme. Copyright © 2014 John Wiley & Sons, Ltd.
Life history of a cyprinid species in non‐regulated and regulated rivers from permanent and temporary Mediterranean basins
Authors: Alexandre C. M. , Ferreira M. T. , Almeida P. R. 
Published: October 2014

AbstractStreamflow variability, natural and human induced, has been suggested as a driver of life history differences among freshwater fish populations. During 1 year, we collected bimonthly and fortnightly samples from four populations of Iberian barbel, inhabiting permanent and temporary Mediterranean rivers with non‐regulated and regulated flow regimes. We analysed data for fish age, growth and reproduction to (i) compare barbels' life cycles between permanent and temporary non‐regulated rivers; (ii) assess the effect of two types of flow alteration in these traits; and (iii) identify flow variables significantly related with growth and reproductive cycles. Regional differences were related with the age of first maturation, growth rate and timing and duration of the reproductive season. Flow regulation promoted a decrease of fish growth rates, condition and gonad activity and an increase of maximum length and longevity. Seasonal variation of growth and gonad maturation were related with temperature and streamflow components. This study offers a multi‐regional perspective of the relationship between fish biological cycles and streamflow variability, providing water resource managers with needed perspective about the effect of anthropogenic alteration of streamflow magnitudes. Copyright © 2014 John Wiley & Sons, Ltd.
Diamondoid‐Structured Cu–Dicarboxylate‐based Metal–Organic Frameworks as High‐Capacity Anodes for Lithium‐Ion Storage
Authors: Senthil Kumar R. , Nithya C. , Gopukumar S. , Anbu Kulandainathan M. 
Published: October 2014

AbstractA versatile electrochemical synthetic route is proposed for the preparation of [Cu2(C8H4O4)4]n metal–organic frameworks. The synthesized composites are characterized by using XRD, SEM, FTIR, and Brunauer–Emmett–Teller (BET) surface analysis. The average particle size was measured to be 8.27 nm and the pore size determined to be 14.06 nm. Here, for the first time, we demonstrate the Cu‐based metal–organic frameworks [Cu2(C8H4O4)4]n as a new class of porous crystalline materials that have the ability to reversibly store Li+ ions. Galvanostatic charge/discharge studies suggest that the terephthalate network reversibly reacts with Li and shows high capacity retention (≈84 % over 50 cycles). The best reversible capacity of 227 mAh g−1 (approximately 95 % of the theoretical capacity) has been achieved in the first cycle at a current density of 24 mA g−1. An easily scalable electrochemical synthesis of the [Cu2(C8H4O4)4]n metal–organic frameworks is an attractive candidate for use with lithium‐ion batteries.
Round‐Robin Studies on Roll‐Processed ITO‐free Organic Tandem Solar Cells Combined with Inter‐Laboratory Stability Studies
Authors: Livi Francesco , Søndergaard Roar R. , Andersen Thomas R. , Roth Bérenger , Gevorgyan Suren , Dam Henrik F. , Carlé Jon E. , Helgesen Martin , Spyropoulos George D. , Adams Jens , Ameri Tayebeh , Brabec Christoph J. , Legros Mathilde , Lemaitre Noëlla , Berny Stephane , Lozman Owen R. , Schumann Stefan , Scheel Arnulf , Apilo Pälvi , Vilkman Marja , Bundgaard Eva , Krebs Frederik C. 
Published: October 2014

AbstractRoll‐processed, indium tin oxide (ITO)‐free, flexible, organic tandem solar cells and modules have been realized and used in round‐robin studies as well as in parallel inter‐laboratory stability studies. The tandem cells/modules show no significant difference in comparison to their single‐junction counterparts and the use of round‐robin studies as a consensus tool for evaluation of organic solar cell parameters is judged just as viable for the tandem solar cells as for single‐junction devices. The inter‐laboratory stability studies were conducted according to testing protocols ISOS‐D‐2, ISOS‐D‐3, and ISOS‐L‐2, and in spite of a much more complicated architecture the organic tandem solar cells show no significant difference in stability in comparison to their single‐junction counterparts.
Training the Next Generation
Authors: Kopp Susan 
Published: October 2014

AbstractAs an educator in an urban veterinary technology program, I often encounter students beginning their professional studies who are passionate about their commitment to a career working with animals. Typically, they have also firmly decided that they will never accept a job in the animal research field. They object to animal research in general because of what they assume is the abject mistreatment of animals housed in laboratories.Chatting again with these students two years later as they prepare for graduation, however, I am increasingly finding that many reconsider those firm convictions. In fact, even in a strong job market for veterinary technicians, some of these graduates are actually choosing to enter the laboratory animal care field.What is causing such an about‐face?
Raising the Bar: The Implications of the IOM Report on the Use of Chimpanzees in Research
Authors: Kahn Jeffrey 
Published: October 2014

AbstractI had the privilege of chairing the Institute of Medicine Committee on the Necessity of Chimpanzees in Biomedical and Behavioral Research in 2011, an effort that has lessons not only about the questions presented to it, but also about the policy and practice of the use of chimpanzees in research and about animal research policy in general. In this essay I will assess the impact and implications of the committee's work and at the same time clarify what I see as its limits. All in all, I believe it is fair to say that the committee's recommendations and the process of its work represent a success for bioethics‐related consensus committees. The combination of topic, timing, and public stakeholder sentiment may have aligned in unique ways that contributed to that success. But even if it turns out to be a special case of sorts, there are lessons to be learned for the future.
U.S. Law and Animal Experimentation: A Critical Primer
Authors: Latham Stephen R. 
Published: October 2014

AbstractEvery country's law permits medical experimentation on animals. While some countries protect particular kinds of animals from being subject to experimentation—notably great apes and endangered species—very few place concrete limitations on what researchers may cause animals to suffer, given sufficient scientific justification. What laws do, instead, is establish standards for the humane treatment and housing of animals in labs, and they encourage researchers to limit or seek alternatives to the use of animals, when doing that is consistent with the scientific goals of their research.The system that has evolved in the United States combines elements of sometimes competing regulatory philosophies. The result is a complex, multilayered system that addresses the most important concerns, but, partly because of historical accident, also leaves some gaps. Even proponents of medical research on animals can see obvious ways in which the regulatory structure could be changed to benefit animals. Perhaps more important, though, is the fact that the existing regulatory structure, imperfect though it may be, is elastic enough to accommodate substantial changes that could reduce unnecessary animal suffering.
The Outsider
Authors: TOMASIC VERONICA 
Published: October 2014

AbstractOn occasion, I am appointed by our local probate court to help make health care decisions for patients who are no longer capable of making these decisions for themselves. I'll visit my client in the hospital and review his or her chart, and I'll have numerous opportunities to talk about the illness and treatment options with attending physicians, residents, and nurses. My phone calls to them will be returned promptly. If doctors arrive at the conclusion that nothing further can be done for the patient, we'll discuss how best to proceed. This end‐of‐life talk never comes as a surprise to me because I will have been included in the team's decision‐making process, in the manner of professionals interacting with another professional.Last fall, I became a family surrogate decision‐maker after my mother was hospitalized over the course of a few months, for a number of reasons, in three hospitals in New York. I assumed I would manage her care as I did my clients’, with a sense of control and involvement in the process, but I quickly learned that I had in fact entered a kind of alternate universe as far as decision‐making was concerned.