bluuebunny/crossref_metadata_2025_split huggingface dataset:
Equity, diversity, and inclusion in oncology pharmacy practice: Everyone's business
Authors: Dettwiller Pascale , Ghiya Suhani , McLean Jurga , O’Callaghan Stewart , Sanni AdeDolapo , Shaunak Nisha , So Lilia , Williamson Steve , Nabhani-Gebara Shereen 
Published: July 2024

Introduction Equity, Diversity, and Inclusion (EDI) is gaining increased attention within all industries healthcare being no exception. The terminology Equity, Diversity, and Inclusion and its abbreviation EDI gained popularity in the early 2000's when varied socio-political factors prompted many organisations to examine EDI concepts and how to operationalise them. The growing diversity of our society requires cross-cultural inclusive approaches to increase equity and access to services. Method This unique research is community-led research supported by the British Oncology Pharmacy Association, in which the members of the BOPA community are equal partners to inform action on policies that address EDI. This research was a cross-sectional study involving an online survey of financial BOPA members. Results Demographic data was extracted, and the quotes were analysed for common themes. The majority of respondents were women, and the largest age group was between 34 and 44. The first cause of microaggressions identified by the respondents was of racial and ethnic origin, followed by marital status and religious nature. Participants described the lack of diversity in senior positions and the microaggressions experienced by those who hold leadership positions. Some participants described how some situations at work made them feel excluded or alienated. The impact of discrimination and bullying/microaggressions extended to patients was also reported. Conclusion Despite strategic directions encompassing this aspect, this research underscores the pressing need for more evidence on the lack of EDI in healthcare institutions. Our findings, located in the pharmacy oncology specialty, have identified the problem and highlighted the potential benefits of addressing it. More needs to be done in training and professional development to address unconscious bias and change behaviours.
Barriers and Enablers to Maintaining Behaviour Changes Following a Lifestyle Intervention for Adults With Type 2 Diabetes
Authors: Healy Genevieve N. , Goode Ana D. , Campbell Lucy , Sikder Amit , Giguere Denis , Gomersall Sjaan R. 
Published: July 2024

Aim To explore short-term barriers and enablers to maintaining behaviour changes in adults with type 2 diabetes who had completed a lifestyle behaviour change program. Methods Focus groups with 44 participants identified barriers and enablers at the end-of-program (n = 8 groups: anticipated); and, 1-month post-program (n = 6 groups: experienced). Thematic inductive analysis was undertaken independently by two authors, discussed, then deductively grouped according to the Capability (physical, psychological), Opportunity (physical, social), Motivation (automatic, reflective) – Behaviour (COM-B) model. Results Nine barriers were identified: two anticipated, one experienced, and six common to both timepoints. Key barriers related to physical capability (health ability), physical opportunity (difficulty accessing and using resources), social opportunity (unwillingness to invest in social networks), and reflective motivation (lack of internal drive). Eleven enablers were identified: all across both timepoints. Key enablers related to psychological capability (knowledge), physical opportunity (access and use of program resources), social opportunity (sense of belonging and safety within the program), automatic motivation (beliefs and awareness around perceived risk; monitoring of progress), and reflective motivation (committed to change). Discussion Findings suggest diabetes management programs should enable ongoing access to their resources. Investing in mechanisms to scaffold program graduates into suitable community-based activities may also be beneficial.
Defining the tipping point for revision reverse shoulder arthroplasty
Authors: Buchanan Timothy R , Hao Kevin A , Cueto Robert J , Bindi Victoria E , O’Keefe Daniel S , Hones Keegan M , Krisanda Emily K , Wright Jonathan O , Wright Thomas W , Farmer Kevin W , Struk Aimee M , Schoch Bradley S , King Joseph J 
Published: July 2024

Background This study sought to characterize the tipping point values (the functional scores that patients deem dysfunctional enough to warrant surgery) for patients undergoing first revision reverse total shoulder arthroplasty (rTSA). Methods This study was a retrospective review of a prospectively collected single-institution database of patients undergoing first revision rTSA between August 2015 and December 2019. Tipping point evaluation utilized preoperative scores including the American Shoulder and Elbow Surgeons (ASES), raw and normalized Constant, Shoulder Pain and Disability Index (SPADI), Simple Shoulder Test (SST), and University of California-Los Angeles (UCLA) scores, and active range of motion including abduction, forward elevation (FE), external rotation (ER), and internal rotation score (IR) prior to elective revision rTSA. Results We included 125 revision rTSAs. Tipping points were 37.6 ASES score, 30.5 raw Constant score, 35.5 normalized Constant score, 68.1 SPADI, 3.7 SST, 13.2 UCLA score, 64° abduction, 69° FE, 23° ER, and 3.1 IR. Higher SST was found for older patients and patients with a lower body mass index. Lower abduction and FE tipping points were reported in patients undergoing revision rTSA for rotator cuff failure, unexplained pain, and implant wear. Discussion These tipping points can help surgeons counsel patients regarding when to undergo revision rTSA. Level of evidence Level III; retrospective cohort study; treatment study.
A unique tribological inverted bearing solution for reverse shoulder arthroplasty: Vitamin E and ceramic (unique inverse pairings in rTSR)
Authors: Krishnan Munish R , Rajaratnam Joshua D , Peiris Dylan , Gupta Manish , Wigmore Estelle , Heinrichs Christian 
Published: July 2024

Background Reverse total shoulder arthroplasty has gained popularity for various shoulder conditions and has evolved over time to accommodate for material changes and design philosophy including inverse materials. The tribological behaviour of shoulder arthroplasty has been extensively studied in relation to biological osteolysis which is a notable concern regarding component loosening. Methods This study aims to assess the wear performance of a vitamin E-stabilised glenosphere or conventional ultra-high-molecular-weight polyethylene glenosphere whilst paired with ceramic or cobalt–chrome–molybdenum inlay in a shoulder joint wear simulator. A cumulative total of five million cycles was utilised with gravimetric and visual analysis of wear. Results Gravimetric wear was observed to be the lowest when a vitamin E-stabilised glenosphere was paired with a ceramic inlay – demonstrating the greatest wear resistance. Conclusion Our results demonstrate that the combination of vitamin E-stabilised polyethylene glenosphere and ceramic inlay has improved wear resistance properties in load simulations when compared to other bearing surface combinations. This supports the use of the novel inverse combination in clinical practice to attain longer-term survivorship in reverse total shoulder replacements. Level of evidence Basic Science Study; Tribology
Fatty Acid Esters and Acyclic Monoterpenoid from Justicia insularis Leaf Fractions Attenuated Malaria Pathogenesis Through Docking with Plasmodium falciparum Serine Hydroxymethyl Transferase and Plasmodium falciparum Erythrocyte Membrane Protein 1 Proteins
Authors: Enyiekere Veronica James , Asanga Edet Effiong , Okokon Jude Efiom , Ekeleme Chinedum Martins , Anagboso Martin Osita , Uduak Ise Peter 
Published: July 2024

Background Justicia insularis (Acanthaceae) T. Anderson is ethnopharmacologically used in Nigeria for the treatment of diseases including malaria. Therefore, this study was designed to investigate in vivo antiplasmodial effect of J. insularis leaf in Plasmodium berghei-infected mice, characterize its constituents, and carryout in silico studies of its compounds. Methods Standard protocols were followed in the processing of the plant leaves, extraction, fractionation, isolation, and characterization, evaluation of in vivo antiplasmodial assay, retrieval of Plasmodium falciparum serine hydroxymethyl transferase (PfSHMT) and Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP-1) proteins, absorption, distribution, metabolism, excretion, and toxicity (ADMET), and docking studies. Gas chromatography-mass spectrometry (GC-MS) was employed to isolate and characterize the compounds; SWISSADME and ADMET lab 2 enhanced the evaluation of pharmacokinetic properties, PyRx for docking analysis; Biovia discovery studio for 2D visualization, and PyMol software for 3D visualization of the ligand-protein interactions. Results The dichloromethane (61.59%) and ethyl acetate (73.15%) fractions had the best therapeutic indices and compared favorably with chloroquine (81.58%) in the curative antiplasmodial assay. The GC-MS analysis revealed 20 already reported antiplasmodial compounds with hexanoic acid 1,1-dimethylethyl ester, octadecanoic acid docosyl ester, and trans-β-ocimene as the lead compounds based on their binding affinities, permeation of the blood-brain-barrier, non-inhibition of metabolizing enzymes, ease of excretion, non-carcinogenicity, as well as non-violation of Lipinski's criteria. Conclusion Octadecanoic acid docosyl ester and hexanoic acid 1,1-dimethylethyl ester bonded the tetrahydrofolate-binding sites of PfSHMT, caused inhibition of DNA synthesis, and apoptosis, whereas trans-β-ocimene inhibited PfEMP-1, reversed the attachment of parasitized red blood cells to micro-vascular endothelium as their mechanism of action for parasitemia clearance. Moreover, these lead compounds reported for the first time in the dichloromethane and EtoAc fractions of this plant are responsible for the remarkable antiplasmodial activity observed in this study.
Production of nanocomposite films based on low density polyethylene/surface activated nanoperlite for modified atmosphere packaging applications
Authors: Sahraeian Razi , Paran Seyed Mohamad Reza , Esfandeh Masoud , Naderi Ghasem 
Published: July 2024

The modified atmosphere packaging films based on polyethylene nanocomposites reinforced with perlite nanoparticles were prepared using a blow molding machine. The perlite particles were first reduced to nano dimensions using an abrasive mill, then the porosity of nanoperlite was increased to improve their efficiency in absorbing ethylene gas. For this purpose, 6 normal sodium hydroxide solution at 50°C temperature was used. Finally, perlite nanoparticles were modified by polymethyl hydrogen siloxane silane compound. In each of the stages of grinding and modifying the perlite surface, the necessary tests including dynamic light diffraction test, nitrogen absorption test and ethylene gas absorption test were performed using gas chromatography method. The results showed that the size of perlite particles was reduced to 500 nm by using an abrasive mill, and the surface modification process increased the specific surface area of perlite by 10 times. Based on this, the amount of ethylene gas absorption in perlite nanoparticles with modified surface increased up to 3 times compared to normal perlite. The results of the gas chromatography test showed that the nanocomposite film based on polyethylene reinforced with 6% by weight of modified perlite nanoparticles has several times the efficiency in absorbing ethylene gas compared to the potassium permanganate sachets The results of the mechanical properties tests of nanocomposite film in comparison with pure polyethylene film showed that nanocomposite film has higher properties than pure polyethylene. The results of shelf-life tests of green tomatoes packed in nanocomposite film based on polyethylene reinforced with modified nanoperlite showed that green tomatoes can be stored for two months using the prepared modified atmosphere packaging.
Effectiveness of self-reported management program of cancer patients
Authors: Sin Cheolkyung , Lee Dong Yeop , Kim Hyeyeong , Im Hyeon-Su , Koh Su-Jin , Kang Dong Yoon 
Published: July 2024

Objective This study aimed to analyze the effect of Smart Cancer Care program on the quality of life and ease of chemotherapy continuation in cancer patients and the effect of additional tele-management on frequency of use and satisfaction with the Smart Cancer Care program. Methods ‘Smart Cancer Care’ is a mobile program that allows cancer patients undergoing chemotherapy to report symptoms of adverse events and receive remote management. In this study, patients were randomly assigned to three groups: Group A, who received only classical face-to-face management; Group B, who used the Smart Cancer Care program as addition; and Group C, who used the Smart Cancer Care program and received telephone management. After 12 weeks of follow-up, the effectiveness of using the Smart Cancer Care program was analyzed by examining the quality of life, ease of maintaining chemotherapy, and unplanned hospital visits in each group. The frequency of use and satisfaction with the Smart Cancer Care program were also analyzed. Results Cancer patients who used the Smart Cancer Care program had 1.93-fold (1.15–3.25) higher overall quality of life than those who did not. This became 2.33-fold (1.34–4.04) higher when phone care was added. Patients with tele-management were significantly more likely to use the Smart Cancer Care program (odds ratio (OR) = 25.80; 95% confidence interval (CI), 11.28–58.97). Conclusions A mobile self-reported management program has a positive effect on the quality of life of cancer patients undergoing chemotherapy. Tele-management is conducive to active and effective use of this program.
Stakeholder perspectives on ethical and trustworthy voice AI in health care
Authors: Bélisle-Pipon Jean-Christophe , Powell Maria , English Renee , Malo Marie-Françoise , Ravitsky Vardit ,   Bridge2AI–Voice Consortium, Bensoussan Yael 
Published: July 2024

Objective Voice as a health biomarker using artificial intelligence (AI) is gaining momentum in research. The noninvasiveness of voice data collection through accessible technology (such as smartphones, telehealth, and ambient recordings) or within clinical contexts means voice AI may help address health disparities and promote the inclusion of marginalized communities. However, the development of AI-ready voice datasets free from bias and discrimination is a complex task. The objective of this study is to better understand the perspectives of engaged and interested stakeholders regarding ethical and trustworthy voice AI, to inform both further ethical inquiry and technology innovation. Methods A questionnaire was administered to voice AI experts, clinicians, scholars, patients, trainees, and policy-makers who participated at the 2023 Voice AI Symposium organized by the Bridge2AI-Voice AI Consortium. The survey used a mix of Likert scale, ranking and open-ended questions. A total of 27 stakeholders participated in the study. Results The main results of the study are the identification of priorities in terms of ethical issues, an initial definition of ethically sourced data for voice AI, insights into the use of synthetic voice data, and proposals for acting on the trustworthiness of voice AI. The study shows a diversity of perspectives and adds nuance to the planning and development of ethical and trustworthy voice AI. Conclusions This study represents the first stakeholder survey related to voice as a biomarker of health published to date. This study sheds light on the critical importance of ethics and trustworthiness in the development of voice AI technologies for health applications.
Construction and evaluation of acquired weakness nomogram model in patients with mechanical ventilation in intensive care unit
Authors: Lu Chen , Wenjuan Jiang 
Published: July 2024

Objective The incidence of intensive care unit acquired weakness (ICU-AW) has shown an increasing trend with still a lack of effective treatment options. The early assessment of the risk of developing ICU-AW can provide patients with targeted interventions. This study aimed to determine the independent risk factors of ICU-AW in patients receiving mechanical ventilation (MV) and develop a nomogram and verify its predictive efficacy. Methods This observational study included patients receiving MV therapy in the ICU of our hospital between January 2020 and January 2023. They were divided into the ICU-AW and non-ICU-AW groups. The training cohort (n = 264) and the validation cohort (n = 143) were constructed. Multivariate logistic regression analyses were used to select the risk factors, and a nomogram model was established. Calibration, receiver operating characteristic (ROC), and decision curves were used to evaluate the effectiveness of the model. Results The MV duration (OR = 1.24, 95%CI[1.11, 1.38]), APACHE II score (OR = 1.34, 95%CI[1.20, 1.50]), SOFA score (OR = 1.36, 95%CI[1.21, 1.53]), age (OR = 1.05, 95%CI[1.00, 1.10]), nerve blockers (OR = 3.26, 95%CI[1.34, 7.92]), and diabetes mellitus (OR = 3.12, 95%CI[1.10, 8.87]) were independent risk factors for ICU-AW. The nomogram had good predictive efficacy for both the training (area under the curve (AUC) = 0.950, 95%CI [0.93, 0.97]) and validation cohorts (AUC = 0.823, 95%CI [0.75, 0.89]). Conclusion The MV duration, APACHE II, SOFA, age, use of nerve blockers, and diabetes mellitus are independent risk factors for ICU-AW. The nomogram model based on them had good predictive efficacy and may be clinically useful.
The Pedagogy of Place in China's Migrant Community
Authors: Yu (余旻) Min 
Published: July 2024

Purpose This article examines the curriculum and pedagogy of place for migrant children in China and advocates the recognition of migrant families’ and communities’ knowledge as necessary, relevant, and impactful curriculum. Design/Approach/Methods This article is based on a longitudinal qualitative study conducted in various migrant settlements in Beijing. Data were collected from in-depth interviews with migrant parents, teachers, and community activists and participant observations in schools, community meetings, and other gatherings in the communities. Data were coded on themes related to place-based connection, attachment, and belonging and then analyzed. Findings Findings demonstrate that pedagogical practices can be developed to re-center the knowledge and experiences of Chinese migrant communities. This pedagogical work recognizes and reflects the undervalued and unrecognized knowledge of migrant communities while investigating the meaning of “place” for migrant children. Originality/Value This is the first study putting special emphasis on the discussion of what “place” means for migrants and what knowledge is worthwhile for their children in China. A key contribution of this article is that it documents the challenges and benefits of creating a place-based curriculum and pedagogy for migrant children as they construct a sense of belonging.
Higher Education, Digital Economy, and Common Prosperity
Authors: Zhang (张玉鹏) Yupeng , Wang (王茜) Qian 
Published: July 2024

Purpose This study examines the influence of higher education and the digital economy on common prosperity at the provincial, urban, and rural levels, as well as how the digital economy mediates the effect of higher education on common prosperity. Design/Approach/Methods Based on Chinese provincial panel data from 2011 to 2020, this study constructs a novel index to measure the common prosperity index at the provincial, urban, and rural levels that comprise the dimensions of “development” and “sharing.” The panel data method is used to accomplish the empirical studies. Findings First, increasing the proportion of higher education had a significant positive impact on common prosperity at the provincial, urban, and rural levels. Second, the development of the digital economy had a significant impact on common prosperity at the rural level only. Third, developing the digital economy strengthened the positive role of higher education in promoting common prosperity at the provincial and urban levels. Originality/Value The results indicate that expanding the scale of higher education and deepening the development of the digital economy are effective means of promoting common prosperity. Government can exert the positive moderating role of the digital economy in the beneficial effect of higher education on common prosperity.
Differentiated Instruction in Chinese Primary and Secondary Schools: A Systematic Literature Review
Authors: Bi (毕美杰) Meijie , Struyven Katrien , Zhu (朱畅) Chang 
Published: July 2024

Purpose This study explores the current status of differentiated instruction (DI) in Chinese mainland primary and secondary schools. Design/Approach/Methods This study comprises a systematic review of the Chinese literature. Forty-five articles, published between 2000 and 2022, were reviewed and the results are presented as a thematic overview. Findings Chinese characteristics have contributed to the distinctive development of Chinese DI. Chinese researchers have defined DI as both a teaching concept and a practice. Chinese scholars have suggested strategies for teachers to use, including flexible grouping, tiered instruction, and multiple forms of evaluation, along with the use of non-graded classes and artificial intelligence. This study identifies barriers to teachers’ adoption of DI including large class size and China's examination-oriented culture. However, Confucian belief was effectively a forerunner of DI. Originality/Value This study offers insights and practical suggestions for those seeking to promote DI in Chinese mainland; for example, class sizes should be reduced, and teachers should receive relevant professional training. This study identifies a pressing need for empirical research of DI implementation in schools in Chinese mainland.
Optimal Dosage and Session Structure of Mindfulness-Based Programming for Youth Across Developmental Periods: Delphi Approach Outcomes
Authors: Felver Joshua C. , Helminen Emily C. , Schutt Mary Katherine A. , Cary Emily L. , Schussler Deborah L. , Baelen Rebecca N. , Gould Laura F. , Roeser Robert W. 
Published: July 2024

Purpose Research of mindfulness-based programming/interventions (MBP) for youth has proliferated in recent years; however, heterogeneity of MBP for youth impede determination of optimal programmatic structure across developmental periods. Design/Approach/Methods Expert MBP scientists and instructors were iteratively surveyed using the Delphi method to assess optimal MBP session structure across developmental periods. Findings Survey Round 1 defined the participants’ perspective of ideal structure across early childhood, middle childhood, and adolescence. In Survey Rounds 2 and 3, participants considered the preceding Round's results (means and SDs) and indicated what they believed was the ideal structure of a single MBP class. Final results following the Round 3 survey indicated that MBP session period should be progressively longer relative to the developmental time period (early childhood mean = 20.0 min; middle childhood mean = 34.5 min; adolescence mean = 50.0 min); that roughly half of a youth MBP session should be dedicated to mindfulness practice; and that progressively more time should be allocated to didactic instruction and discussion, relative to mindfulness practice, as youth become older. Originality/Value These findings are the first to report expert feedback on the ideal structure of a youth MBP session, and results have significant implications for future youth MBP evaluation, implementation, and curriculum development.