bluuebunny/crossref_metadata_2025_split huggingface dataset:
Origins of the Enantio‐ and N/O Selectivity in the Primary‐Amine‐Catalyzed Hydroxyamination of 1,3‐Dicarbonyl Compounds with In‐Situ‐Formed Nitrosocarbonyl Compounds: A Theoretical Study
Authors: Zhang Long , Xu Changming , Mi Xueling , Luo Sanzhong 
Published: September 2014

AbstractChemoselective control over N/O selectivity is an intriguing issue in nitroso chemistry. Recently, we reported an unprecedented asymmetric α‐amination reaction of β‐ketocarbonyl compounds that proceeded through the catalytic coupling of enamine carbonyl groups with in‐situ‐generated carbonyl nitroso moieties. This process was facilitated by a simple chiral primary and tertiary diamine that was derived from tert‐leucine. This reaction featured high chemoselectivity and excellent enantioselectivity for a broad range of substrates. Herein, a computational study was performed to elucidate the origins of the enantioselectivity and N/O regioselectivity. We found that a bidentate hydrogen‐bonding interaction between the tertiary N+H and nitrosocarbonyl groups accounted for the high N selectivity, whilst the enantioselectivity was determined by Si‐facial attack on the (E)‐ and (Z)‐enamines in a Curtin–Hammett‐type manner. The bidentate hydrogen‐bonding interaction with the nitrosocarbonyl moieties reinforced the facial selectivity in this process.
Multi‐Tracking of First Order Multi‐Agent Networks Via Self‐Triggered Control
Authors: Han Guang‐Song , Guan Zhi‐Hong , Chen Jie , He Ding‐Xin , Chi Ming 
Published: September 2014

AbstractA multi‐tracking problem of multi‐agent networks is investigated in this paper where multi‐tracking refers to that the states of multiple agents in each subnetwork asymptotically converge to the same desired trajectory in the presence of information exchanges among subnetworks. The multi‐tracking of first order multi‐agent networks with directed topologies was studied. Self‐triggered protocols were proposed along with triggering functions to solve the stationary multi‐tracking and bounded dynamic multi‐tracking. The self‐triggered scheduling is obtained, and the system does not exhibit Zeno behavior. Numerical examples are provided to illustrate the effectiveness of the obtained criteria.
Quadratic Optimal Fault Tolerant Control on Wireless Networked Control Systems for Real‐Time Industrial Applications
Authors: Xu Dongmei , Ding Steven X. , Wang Ying , Shen Bo 
Published: September 2014

AbstractIn this paper we study the fault tolerant control (FTC) problem on wireless networked control systems (WNCSs) which have been aware of a bright and broad prospect and taken as a development trend of automation industry. We aim at finding an FTC strategy which makes the WNCSs satisfy a quadratic cost function. The FTC law is designed to be related with the system state and the fault. Considering the system state and the fault may be physically unaccessible in the actual control process, an estimation scheme is proposed to estimate the system state and fault simultaneously. Finally, an experimental application is presented to demonstrate the effectiveness of the proposed method.
The preservation of islet with alginate encapsulation in the process of transportation
Authors: Li Na , Zhang Ying , Xiu Zhilong , Wang Yu , Chen Li , Wang Shujun , Li Shen , Guo Xin , Ma Xiaojun 
Published: September 2014

AbstractRestoration of insulin secretion by transplantation of isolated islets is a treatment for type Ι diabetes mellitus. One of the major issues with clinical treatment of islet transplantation is how to maintain islet viability during transportation from the donor to the patient. We developed a method that uses alginate encapsulation to protect islets from mechanical damage during shipment. We tested several variables for their impact on islet viability during transportation and used the significant variable to build a response surface methodology (RSM) model by the Box–Behnken design method. This type of model is a mathematical and statistical technique that we used to optimize the conditions for islet viability during shipment. In this study, the factors that significantly affected islet survival rate were incubation time, serum concentration, and preservation time. Then, an empirical model was built to optimize conditions of the islets for shipping according to the responses of the effect factors with RSM. This model can be used to predict the islet survival rate and can serve as a guide for optimizing the transportation method of islets and increasing the success rate of the transplant procedure.
The affect heuristic in early judgments of product innovations
Authors: King Jesse , Slovic Paul 
Published: September 2014

ABSTRACTAccording to the affect heuristic, people often rely upon their overall affective impression of a target to form judgments of risk. However, innovation research has largely characterized risk perception as a function of what the consumer knows rather than how they feel. In three studies, this research investigates the use of the affect heuristic in consumer judgments of product innovations. The findings indicate that judgments of risks and benefits associated with product innovations are inversely related and affectively congruent with evaluations of those innovations. Additionally, more affectively extreme evaluations are associated with increasingly disparate judgments of risk and benefit. This research contributes to our theoretical understanding of both consumers' evaluations of product innovations and the affect heuristic. Implications and suggestions for future research are also discussed. Copyright © 2014 John Wiley & Sons, Ltd.
Reversible Covalent Inhibition of eEF‐2K by Carbonitriles
Authors: Devkota Ashwini K. , Edupuganti Ramakrishna , Yan Chunli , Shi Yue , Jose Jiney , Wang Qiantao , Kaoud Tamer S. , Cho Eun Jeong , Ren Pengyu , Dalby Kevin N. 
Published: September 2014

AbstracteEF‐2K is a potential target for treating cancer. However, potent specific inhibitors for this enzyme are lacking. Previously, we identified 2,6‐diamino‐4‐(2‐fluorophenyl)‐4H‐thiopyran‐3,5‐dicarbonitrile (DFTD) as an inhibitor of eEF‐2K. Here we describe its mechanism of action against eEF‐2K, on the basis of kinetic, mutational, and docking studies, and use chemoinformatic approaches to identify a similar class of carbonitrile‐containing compounds that exhibit the same mechanism of action. We show that DFTD behaves as a reversible covalent inhibitor of eEF‐2K with a two‐step mechanism of inhibition: a fast initial binding step, followed by a slower reversible inactivation step. Molecular docking suggests that a nitrile group of DFTD binds within 4.5 Å of the active site Cys146 to form a reversible thioimidate adduct. Because Cys146 is not conserved amongst other related kinases, targeting this residue holds promise for the development of selective covalent inhibitors of eEF‐2K.
Cutaneous lymphocyte antigen expression loss and PD1 positivity in early cutaneous lesions of rapidly progressive mycosis fungoides
Authors: Ogunrinade Olakunle , Ahn Christine S. , Gergis Usama , Yassin Aminah H. , Magro Cynthia 
Published: September 2014

Key Clinical MessageIt's important to assess cases both clinically and pathologically for factors potentially predictive of an aggressive clinical course. We concluded that the relative immunosuppressive effects of PD1 may contribute to tumor progression while the lack of staining for cutaneous lymphocyte antigen may be an additional factor facilitating distant extracutaneous migration.
Phenotypic variation of autosomal recessive pseudohypoaldosteronism type I: a case in point
Authors: Kala Ahluwalia Gunjeet , Dasouki Majed , Lennon Angela 
Published: September 2014

Key Clinical MassageWe present a 27‐month‐old male infant with pseudohypoaldosteronism, with two novel α‐subunits, epithelial sodium channel (ENaC) mutations. Despite the presence of the ENaC in the lungs, kidneys, and exocrine glands, he continues to only have renal and exocrine involvement, stressing differential effects of the mutation in each organ.
Itch itch with not a wink of sleep
Authors: Baruah Rishiraj , Sabaretnam Mayilvaganan 
Published: September 2014

Key Clinical MessageA 55‐year‐old man of dark complexion presented with multiple extensive swellings over the chest, right upper arm, and left shoulder for 10 years. Swellings were hyperpigmented, firm, and intensely pruritic especially over the chest region. The swellings progressed in size, extended, and developed satellite lesions over its 10 years history.
A successful early gore‐tex reconstruction of an abdominal wall defect in a neonate with Cantrell pentalogy: a case report and literature review
Authors: Divkovic Dalibor , Kvolik Slavica , Sipl Mirna , Sego Krunoslav , Puseljic Silvija , Rakipovic‐Stojanovic Andreja , Kovacic Borna 
Published: September 2014

Key Clinical MessageA surgical technique, materials used for abdominal wall reconstruction, and postoperative care are important for patient outcomes. We report the first case of neonate with Cantrell's pentalogy surviving early reconstruction of abdominal, diaphragmal and pericardial defects. Several recent investigations suggest that intraabdominal pressure monitoring may improve outcomes in this patient category.
Acute appendicitis caused by acute myeloid leukemia
Authors: Zhang Shanxiang , Chen Shaoxiong 
Published: September 2014

Key Clinical MessageA case of appendiceal involvement by acute myeloid leukemia (AML) in an adult with recent history of AML transformed from myelodysplastic syndrome (MDS) was presented. Being aware of this rare presentation in particular in a patient with history of MDS and/or AML is important for prompt clinical diagnosis and management.
Severe Leptospira interrogans serovar Icterohaemorrhagiae infection with hepato‐renal‐pulmonary involvement treated with corticosteroids
Authors: Schulze Marco H. , Raschel Heribert , Langen Heinz‐Jakob , Stich August , Tappe Dennis 
Published: September 2014

Key Clinical MessageThe traditional concept of immediate antibiotic treatment in suspected leptospirosis seems to be especially important for patients up to day 4 of clinical illness. As immune mechanisms probably play a crucial role in advanced leptospirosis with presumed pulmonary hemorrhages, patients might benefit from corticosteroids or other immunosuppressive agents beside antibiotics.
Herniorrhaphy: an unusual cause of ureteral injury in Nigeria
Authors: Eziyi Amogu K. , Etonyeaku Amarachukwu C. , Olajide Abimbola O. , Adejumobi Musibau. O 
Published: September 2014

Key Clinical MessageHerniorrhaphy is a common surgery worldwide. Common complications include hemorrhage, infection, chronic pain, and recurrence. Ureteric injury from herniorrhaphy is unusual. We present a case of ureteric injury complicating an inguinal herniorrhaphy for a huge right inguino‐scrotal hernia. Patient had primary uretero‐neocystostomy but died from septicemia in the postoperative period.
Rhodium‐Catalyzed Decarbonylative Direct C2‐Arylation of Indoles with Aryl Carboxylic Acids
Authors: Zhang Lingjuan , Xue Xiao , Xu Conghui , Pan Yixiao , Zhang Guang , Xu Lijin , Li Huanrong , Shi Zhangjie 
Published: September 2014

AbstractA RhI‐catalyzed direct C2‐arylation of indoles with diversely substituted aryl carboxylic acids has been developed using 2‐pyrimidyl group as an easily installable and readily removable N‐directing group. The reaction proceeded smoothly without the need for any external oxidants under relatively mild conditions to produce the C2‐arylated indoles in high yields with excellent regioselectivity. A range of functional groups in both coupling partners were tolerated regardless of their electronic properties and positions. With the assistance of the 2‐pyrimidyl group, these C2‐functionalized products could further undergo C7‐arylation to give the C7‐aryl indole products. Mechanistic evidence supports that the reaction involves a decarbonylation step, and the carboxylic acids could be activated in situ by treatment with (tBuCO)2O to generate the active anhydrides.
Use of Diode Analogy in Explaining the Voltammetric Characteristics of Immobilized Ferrocenyl Moieties on a Silicon Surface
Authors: Herrera Marvin U. , Ichii Takashi , Murase Kuniaki , Sugimura Hiroyuki 
Published: September 2014

AbstractThe creation of a model that explains the dependency of the voltammetric characteristics of ferrocene‐terminated Si (Si‐Fc) samples on the type of substrate (n‐ or p‐type) would be helpful in understanding the electronic characteristics of these materials. To explain the dependency, Si‐Fc samples are treated like diodes. As diodes, the samples may allow charge flow in a certain direction while inhibiting the opposite flow. The treatment of a sample as a diode is done to facilitate analysis of charge flow within the sample, thus enabling easy prediction of its electrochemical characteristics. Likewise, the trend of the anodic peak potential versus light intensity plot (of the samples with n‐type substrate) is also associated with the sample’s diode characteristics. Our proposed model opens many scientific possibilities, especially in relating the voltammetric characteristics of electroactive molecules on a Si surface with the properties of a diode (e.g., open‐circuit voltage).
Distinctive Potential Behavior at Oxidized Surface of Semiconductor Device in Concentrated Aqueous Salt Solution
Authors: Maekawa Yuki , Shibuta Yasushi , Sakata Toshiya 
Published: September 2014

AbstractThe cover artwork is provided by the Sakata laboratory. The image shows the SiO2/NaCl(aq) interface obtained in silico by molecular dynamics simulation, reflecting the electrical measurement obtained on silico from a semiconductor‐based biosensor. Read the full text of the article at 10.1002/celc.201402069.
Tailoring the Structure of Two‐Dimensional Self‐Assembled Nanoarchitectures Based on NiII–Salen Building Blocks
Authors: Viciano‐Chumillas Marta , Li Dongzhe , Smogunov Alexander , Latil Sylvain , Dappe Yannick J. , Barreteau Cyrille , Mallah Talal , Silly Fabien 
Published: September 2014

AbstractThe synthesis of a series of NiII–salen‐based complexes with the general formula of [Ni(H2L)] (H4L=R2‐N,N′‐bis[R1‐5‐(4′‐benzoic acid)salicylidene]; H4L1: R2=2,3‐diamino‐2,3‐dimethylbutane and R1=H; H4L2: R2=1,2‐diaminoethane and R1=tert‐butyl and H4L3: R2=1,2‐diaminobenzene and R1=tert‐butyl) is presented. Their electronic structure and self‐assembly was studied. The organic ligands of the salen complexes are functionalized with peripheral carboxylic groups for driving molecular self‐assembly through hydrogen bonding. In addition, other substituents, that is, tert‐butyl and diamine bridges (2,3‐diamino‐2,3‐dimethylbutane, 1,2‐diaminobenzene or 1,2‐diaminoethane), were used to tune the two‐dimensional (2D) packing of these building blocks. Density functional theory (DFT) calculations reveal that the spatial distribution of the LUMOs is affected by these substituents, in contrast with the HOMOs, which remain unchanged. Scanning tunneling microscopy (STM) shows that the three complexes self‐assemble into three different 2D nanoarchitectures at the solid–liquid interface on graphite. Two structures are porous and one is close‐packed. These structures are stabilized by hydrogen bonds in one dimension, while the 2D interaction is governed by van der Waals forces and is tuned by the nature of the substituents, as confirmed by theoretical calculations. As expected, the total dipolar moment is minimized
Self‐Directed Orientation of Molecular Columns Based on n‐Type Hexaazatrinaphthylenes (HATNAs) for Electron Transport
Authors: Liu Xu‐Ying , Usui Takayuki , Hanna Junichi 
Published: September 2014

AbstractSelf‐organizing n‐type hexaazatrinaphthylenes (HATNAs) with various bay‐located side chains have been synthesized. The HATNA derivatives are able to form long‐range molecular columns with self‐directed growth directions. In particular, alkyl‐substituted HATNAs showed in‐plane molecular columns with axes parallel to substrates, whereas the columnar orientation of the HATNAs with alkylethynyl or alkylthio groups strongly depended on the length of the introduced side chains. Interestingly, the derivative with octylthio chains exhibited out‐of‐plane molecular columns, in which electron mobility of up to 10−3 cm2 V−1 s−1 was determined through the time‐of‐flight technique, highlighting the fact that such molecular columns based on bay‐substituted HATNAs are promising n‐type semiconductors for device applications.
Broadband Visible‐Light‐Harvesting trans‐Bis(alkylphosphine) Platinum(II)‐Alkynyl Complexes with Singlet Energy Transfer between BODIPY and Naphthalene Diimide Ligands
Authors: Liu Lianlian , Guo Song , Ma Jie , Xu Kejing , Zhao Jianzhang , Zhang Tierui 
Published: September 2014

AbstractA heteroleptic bis(tributylphosphine) platinum(II)‐alkynyl complex (Pt‐1) showing broadband visible‐light absorption was prepared. Two different visible‐light‐absorbing ligands, that is, ethynylated boron‐dipyrromethene (BODIPY) and a functionalized naphthalene diimide (NDI) were used in the molecule. Two reference complexes, Pt‐2 and Pt‐3, which contain only the NDI or BODIPY ligand, respectively, were also prepared. The coordinated BODIPY ligand shows absorption at 503 nm and fluorescence at 516 nm, whereas the coordinated NDI ligand absorbs at 594 nm; the spectral overlap between the two ligands ensures intramolecular resonance energy transfer in Pt‐1, with BODIPY as the singlet energy donor and NDI as the energy acceptor. The complex shows strong absorption in the region 450 nm–640 nm, with molar absorption coefficient up to 88 000 M−1 cm−1. Long‐lived triplet excited states lifetimes were observed for Pt‐1–Pt‐3 (36.9 μs, 28.3 μs, and 818.6 μs, respectively). Singlet and triplet energy transfer processes were studied by the fluorescence/phosphorescence excitation spectra, steady‐state and time‐resolved UV/Vis absorption and luminescence spectra, as well as nanosecond time‐resolved transient difference absorption spectra. A triplet‐state equilibrium was observed for Pt‐1. The complexes were used as triplet photosensitizers for triplet–triplet annihilation upconversion, with upconversion quantum yields up to 18.4 % being observed for Pt‐1.
Partial Charge Transfer in the Shortest Possible Metallofullerene Peapod, La@C82⊂[11]Cycloparaphenylene
Authors: Iwamoto Takahiro , Slanina Zdenek , Mizorogi Naomi , Guo Jingdong , Akasaka Takeshi , Nagase Shigeru , Takaya Hikaru , Yasuda Nobuhiro , Kato Tatsuhisa , Yamago Shigeru 
Published: September 2014

Abstract[11]Cycloparaphenylene ([11]CPP) selectively encapsulates La@C82 to form the shortest possible metallofullerene–carbon nanotube (CNT) peapod, La@C82⊂[11]CPP, in solution and in the solid state. Complexation in solution was affected by the polarity of the solvent and was 16 times stronger in the polar solvent nitrobenzene than in the nonpolar solvent 1,2‐dichlorobenzene. Electrochemical analysis revealed that the redox potentials of La@C82 were negatively shifted upon complexation from free La@C82. Furthermore, the shifts in the redox potentials increased with polarity of the solvent. These results are consistent with formation of a polar complex, (La@C82)δ−⊂[11]CPPδ+, by partial electron transfer from [11]CPP to La@C82. This is the first observation of such an electronic interaction between a fullerene pea and CPP pod. Theoretical calculations also supported partial charge transfer (0.07) from [11]CPP to La@C82. The structure of the complex was unambiguously determined by X‐ray crystallographic analysis, which showed the La atom inside the C82 near the periphery of the [11]CPP. The dipole moment of La@C82 was projected toward the CPP pea, nearly perpendicular to the CPP axis. The position of the La atom and the direction of the dipole moment in La@C82⊂[11]CPP were significantly different from those observed in La@C82⊂CNT, thus indicating a difference in orientation of the fullerene peas between fullerene–CPP and fullerene–CNT peapods. These results highlight the importance of pea–pea interactions in determining the orientation of the metallofullerene in metallofullerene–CNT peapods.
Asymmetric Reduction of α‐Amino Ketones with a KBH4 Solution Catalyzed by Chiral Lewis Acids
Authors: He Peng , Zheng Haifeng , Liu Xiaohua , Lian Xiangjin , Lin Lili , Feng Xiaoming 
Published: September 2014

AbstractAn efficient enantioselective reduction of α‐amino ketones with potassium borohydride solution catalyzed by chiral N,N′‐dioxide–metal complex catalysts was accomplished under mild reaction conditions for the first time. It provided a simple, convenient, and practical approaches for obtaining synthetically important chiral β‐amino alcohols in good to excellent yields (up to 98 %) and enantioselectivities (up to 97 % ee).
Synthesis of Cs2.5H0.5PW12O40/TiO2 Nanocomposites with Dominant TiO2 {001} Facets and Related Photocatalytic Properties
Authors: Hu Yichen , Ren Yuanhang , Tang Gangfeng , Wang Cheng , Tang Min , Yue Bin , He Heyong 
Published: September 2014

AbstractTiO2 nanosheets with dominant {001} facets, coupled with Cs2.5H0.5PW12O40, were successfully synthesized by a one‐step hydrothermal reaction. The photocatalytic activity of nanocatalysts was evaluated by the degradation of Rhodamine B under UV light irradiation. The results showed that both the addition of Cs2.5H0.5PW12O40 and the exposed {001} facets of TiO2 have a positive effect on the photocatalytic activity. The improved photoactivity of nanocomposites in comparison with that of TiO2 nanosheets could be attributed to the synergistic effect between Cs2.5H0.5PW12O40 and TiO2 which facilitates the separation of photo‐induced hole‐electron pairs.
Synthesis of 6‐Alkylidene‐5,6‐dihydro‐4H‐1,3‐thiazine Derivatives via the Cyclization of N‐3‐Bromo‐3‐alkenylthioamides
Authors: Shen Shusu , Liu Yu 
Published: September 2014

AbstractBy the treatment of N‐3‐bromo‐3‐alkenylthioamides with sodium hydroxide in DMF‐H2O in the presence of tetra‐butylammonium bromide, series of 6‐alkylidene‐5,6‐dihydro‐4H‐1,3‐thiazine derivatives were prepared in moderate to good yields. The cyclization is supposed to proceed via both the intramolecular vinylic nucleophilic substitution and the elimination‐addition mechanisms (formation of acetylenic intermediates) in a competitive manner.
In Situ Preparation of Au‐SH@SO3H‐SBA‐15 Catalyst with Enhanced Activity and Durability in Alkyne Hydration
Authors: Zhu Fengxia , Li Hexing 
Published: September 2014

AbstractA facile approach was developed for synthesizing Au‐SH@SO3H‐SBA‐15 with ordered mesoporous channels by reducing Au3+ to Au nanoparticles with SH‐group bonded to silica support, followed by in situ coordinating Au with the unreacted SH‐groups. This catalyst exhibited high efficiency in alkyne hydration owing to the high activity of uniformly dispersed ultrasmall Au nanoparticles, the diminished diffusion limit due to the mesoporous structure, and the promoting effect of acidic SO3H‐groups resulting from oxidation of the SH‐group by Au3+. Meanwhile, the catalyst could be easily recycled and displayed strong durability owing to the strong hydrothermal stability of mesoporous structure and the enhanced stability against Au leaching due to the Au‐SH coordination bond.
Light Induced Inhibition of Protein Phosphatase Calcineurin
Authors: Quintero Andres , Lin Weilin , Hermann Sophia , Zhang Yixin 
Published: September 2014

AbstractLight‐induced switching of drug activity can be used to realize spatio‐temporal control of biological activity in cells and in vivo. In our study of light‐switchable derivatives of immunosuppressive drug cyclosporin A (CsA) in their inhibition of protein phosphatase calcineurin (CaN), we have discovered that 7‐methyl‐6‐thioguanosine (MESG) inhibits CaN under light irradiation through a photo‐crosslinking mechanism. The inhibition has shown selectivity over other enzymes such as phosphatase PP2A, protease chymotrypsin, and cyclophilin 18, the receptor protein for CsA. The discovery could pave the way to discover new covalent inhibitors for protein phosphtase, to design immunophilin‐independent CaN inhibitors, and to design new light controlled inhibitors to modulate signal transduction.