bluuebunny/crossref_metadata_2025_split huggingface dataset:
Ventricular mechanics in patients with aortic valve disease: longitudinal, radial, and circumferential components
Authors: Leonardi Benedetta , Margossian Renee , Sanders Stephen P. , Chinali Marcello , Colan Steven D. 
Published: February 2013

AbstractBackgroundReduced long-axis shortening despite enhanced global function has been reported in aortic stenosis. We sought to improve the understanding of this phenomenon using multi-dimensional strain analysis in conjunction with the evaluation of left ventricular rotation and twist – ventricular torsion – using tissue Doppler techniques.MethodsA total of 57 patients with variable severity of aortic stenosis, aortic regurgitation, or mixed aortic valve disease, subdivided into six groups, were studied. Ventricular morphology was assessed using long-axis/short-axis and mass/volume ratios, afterload using end-systolic meridional wall stress, and global performance using ejection fraction. The circumferential and longitudinal strain was measured from two-dimensional images, and left ventricular rotation and twist were estimated as the difference in rotation between the base and apex of the ventricle.ResultsAortic stenosis was associated with higher mass/volume, ejection fraction, circumferential strain and left ventricular rotation and twist, significantly lower end-systolic wall stress, and a trend towards lower longitudinal strain compared with normal. Myocardial mechanics in aortic regurgitation were normal despite ventricular dilation. Mixed aortic valve disease showed findings similar to aortic stenosis. Left ventricular rotation and twist correlated with midwall circumferential strain (r = 0.62 and p < 0.0001), endocardial circumferential strain (r = 0.61 and p < 0.0001), and end-systolic wall stress (r = 0.48 and p < 0.0001), but not with longitudinal strain (r = 0.18 and p > 0.05).ConclusionsMyocardial mechanics are normal in patients with aortic regurgitation, independent of abnormalities in cardiac geometry. Conversely, in aortic stenosis and mixed aortic valve disease, significant alterations in the patterns of fibre shortening are found. The effects of stenosis on cardiac function seem to dominate the effect of ventricular remodelling.
Quality of life of adult congenital heart disease patients: a systematic review of the literature
Authors: Fteropoulli Theodora , Stygall Jan , Cullen Shay , Deanfield John , Newman Stanton P. 
Published: February 2013

AbstractAimsThis review explores the quality of life of adult congenital heart disease patients and the relationship between disease severity and quality of life.MethodsWe searched seven electronic databases and the bibliography of articles. The 31 selected studies fulfilled the following criteria: adult population; quantitative; assessment of quality of life and/or impact of disease severity on quality of life using validated measures; English language. Data extraction forms were used to summarise the results.ResultsThere are evident methodological limitations within the reviewed studies such as heterogeneous populations, designs, and quality of life conceptualisations and measurements. Despite these problems, findings suggest that the quality of life of adult congenital heart disease patients is compromised in the physical domain compared with their healthy counterparts, whereas no differences were found in relation to the psychosocial and environmental/occupational domain. Some severity variables appear to be significant correlates of quality of life and could be considered in a future standardised classification of disease severity.ConclusionThe methodological limitations of past research in relation to the definition and measurement of quality of life, the study designs, and disease severity classifications need to be addressed in future studies in order to provide robust evidence and valid conclusions in this area of study. This will enable the development of targeted interventions for the improvement of quality of life in the adult population of congenital heart disease patients.
Intrapericardial immature teratoma in a newborn: a case report
Authors: Milovanovic Vladimir , Lukac Marija , Krstic Zoran 
Published: February 2013

AbstractIntrapericardial teratomas are extremely rare and most often benign tumours. In this paper, we have described a case of intrapericardial teratoma diagnosed prenatally and successfully operated. The presented case is noteworthy as an example of potentially catastrophic cardiorespiratory distress caused by the space-occupying nature of the tumour. A multi-disciplinary approach is mandatory because the tumour most often arises from the ascending aorta and in some cases may require the use of cardiopulmonary bypass.
New Information Technology Tools for a Medical Command System for Mass Decontamination
Authors: Fuse Akira , Okumura Tetsu , Hagiwara Jun , Tanabe Tomohide , Fukuda Reo , Masuno Tomohiko , Mimura Seiji , Yamamoto Kaname , Yokota Hiroyuki 
Published: February 2013

AbstractIn a mass decontamination during a nuclear, biological, or chemical (NBC) response, the capability to command, control, and communicate is crucial for the proper flow of casualties at the scene and their subsequent evacuation to definitive medical facilities. Information Technology (IT) tools can be used to strengthen medical control, command, and communication during such a response. Novel IT tools comprise a vehicle-based, remote video camera and communication network systems.During an on-site verification event, an image from a remote video camera system attached to the personal protective garment of a medical responder working in the warm zone was transmitted to the on-site Medical Commander for aid in decision making. Similarly, a communication network system was used for personnel at the following points: (1) the on-site Medical Headquarters; (2) the decontamination hot zone; (3) an on-site coordination office; and (4) a remote medical headquarters of a local government office. A specially equipped, dedicated vehicle was used for the on-site medical headquarters, and facilitated the coordination with other agencies.The use of these IT tools proved effective in assisting with the medical command and control of medical resources and patient transport decisions during a mass-decontamination exercise, but improvements are required to overcome transmission delays and camera direction settings, as well as network limitations in certain areas.FuseA, OkumuraT, HagiwaraJ, TanabeT, FukudaR, MasunoT, MimuraS, YamamotoK, YokotaH. New Information Technology tools for a medical command system for mass decontamination. Prehosp Disaster Med.2013;28(3):1-3.
Corelli, Politics and Music during the Visit of Philip V to Naples in 1702
Authors: DOMÍNGUEZ JOSÉ MARÍA 
Published: February 2013

ABSTRACTThis article discusses and places in historical context a newly discovered set of letters between Cardinal Pietro Ottoboni and his agent in Naples during the visit of King Philip V of Spain to the city in 1702. These letters, in part transcribed in an Appendix, clarify several details concerning Corelli's visit to the city and confirm that he was accompanied by the violinist Matteo Fornari as well as by a third musician, the cellist Pippo Amadei, instead of G. L. Lulier, as hitherto supposed. With new facts that augment information already known from other sources, such as the correspondence of Cardinal Francesco Maria de' Medici, the article sheds new light on disputes that occurred at this time between other musicians and their patrons, such as those involving G. B. Stuck and the Giudice family. Considering these facts in the wider context of the War of the Spanish Succession, I argue that Corelli's visit was the subject of significant political calculations on the part of Cardinal Ottoboni and members of the Spanish and Neapolitan nobility.
Democracy, Oil, or Religion? Expanding Women's Rights in the Muslim World
Authors: Chaturvedi Neilan S. , Montoya Orlando 
Published: February 2013

AbstractOf the 45 Muslim majority countries in the world, 42 have signed the Convention on the Elimination of All Forms of Discrimination Against Women. While this does indeed signal a motive to improve women's rights, there is wide disparity in terms of which countries expand rights and which do not. Social science literature suggests that in addition to economic factors like wealth and oil resources, or political factors like the quality of democracy in the country, Islamic culture may be at odds with the Western conception of women's rights. We posit that Muslim countries are unique in this regard due to religious pressures that often conflict with conventional measures of human rights. Using data from the Cingranelli-Richards Human Rights Dataset and the Religion and State Project, we find that Muslim countries that restrict the influence of fundamentalist religion in the government and population improve women's economic and social rights.
Belonging In a “Christian Nation”: The Explicit and Implicit Associations between Religion and National Group Membership
Authors: Jacobs Carly M. , Theiss-Morse Elizabeth 
Published: February 2013

AbstractIf many consider the United States to be a Christian nation, how does this affect individuals who are American citizens but not Christian? We test two major hypotheses: (1) Americans consider Christians to be more fully American than non-Christians. We examine whether Americans explicitly and implicitly connect being Christian with being a true American; and (2) Christian Americans are more likely to be patriotic and set exclusive boundaries on the national group than non-Christian Americans. Among non-Christians, however, those who want to be fully accepted as American will be more patriotic and set more exclusive boundaries to emulate prototypical Americans than non-Christians who place less emphasis on national group membership. We test these hypotheses using data from a survey and from an Implicit Association Test. We find that Americans in general associate being Christian with being a true American. For Christians, this is true both explicitly and implicitly. For non-Christians, only the implicit measure uncovers an association. We also found that non-Christians exhibit significantly more pro-national group behaviors when they desire being prototypical than when they do not.
Religion and Perceptions of Candidates' Ideologies in United States House Elections
Authors: Jacobsmeier Matthew L. 
Published: February 2013

AbstractUsing data from the American National Election Studies, Poole-Rosenthal DW-Nominate scores, and data on the religious affiliations of members of the United States House of Representatives, I show that religion has important independent effects on the evaluation of candidates' ideologies. The results suggest that candidates affiliated with evangelical Christianity will tend to be seen as more conservative than ideologically similar candidates from mainline Protestant denominations. Jewish candidates, in contrast, will tend to be seen as more liberal than ideologically similar mainline Protestants. Additionally, the use of religion-based stereotypes varies with frequency of church attendance. These findings attest to the external validity of recent experiment-based research on religion-based political stereotypes. The approach employed here also allows for the estimation of the magnitude of the effects of such stereotypes. The results shed light on both the importance of religion in election campaigns and the factors that influence perceptions of candidates' ideologies more generally.
Cognitive impairment in heart failure: results from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME‐CHF) randomized trial
Authors: Huijts Marjolein , van Oostenbrugge Robert J. , Duits Annelien , Burkard Thilo , Muzzarelli Stefano , Maeder Micha T. , Schindler Ruth , Pfisterer Matthias E. , Brunner‐La Rocca Hans‐Peter 
Published: February 2013

AimsUp to 50% of patients with heart failure (HF) may suffer from severe cognitive impairment (SCI), but longitudinal studies are sparse, and effects of changes in HF severity on cognitive function are unknown. Therefore, we assessed the prevalence of SCI in HF patients, its relationship with HF severity, its effects on morbidity and mortality, and the relationship between changes in HF severity and cognitive function.Methods and resultsWe included 611 patients from the Trial of Intensified versus standard Medical therapy in Elderly patients with Congestive Heart Failure (TIME‐CHF) and assessed cognitive function [Hodkinson Abbreviated Mental Test (AMT)] in relation to severity of HF (NYHA class, NT‐proBNP) at baseline and 18 months (n = 382) and effects on hospitalization‐free survival and mortality. SCI (i.e. AMT score ≤7) was present in 9.2% of patients at baseline, but only 20% of them had a diagnosis of dementia. Prevalence of SCI remained stable during follow‐up. SCI was present at baseline more often in NYHA IV patients compared with NYHA II [odds ratio 2.94; 95% confidence interval (CI) 1.15–7.51, P = 0.025], but it was not related to NT‐proBNP levels. SCI was related to higher mortality (hazard ratio 1.53, 95% CI 1.02–2.30, P = 0.04), but not hospitalization‐free survival. Changes in HF severity were not significantly related to changes in cognitive function.ConclusionSCI is a frequent, but often unrecognized finding in HF patients, but the influence of HF severity and its changes on cognitive function were less than hypothesized.Trial registrationISRCTN43596477
TheArabidopsisF-Box Protein CORONATINE INSENSITIVE1 Is Stabilized by SCFCOI1 and Degraded via the 26S Proteasome Pathway
Authors: Yan Jianbin , Li Haiou , Li Shuhua , Yao Ruifeng , Deng Haiteng , Xie Qi , Xie Daoxin 
Published: February 2013

AbstractJasmonate regulates critical aspects of plant development and defense. The F-box protein CORONATINE INSENSITIVE1 (COI1) functions as a jasmonate receptor and forms Skp1/Cullin1/F-box protein COI1 (SCFCOI1) complexes with Arabidopsis thaliana Cullin1 and Arabidopsis Skp1-like1 (ASK1) to recruit its substrate jasmonate ZIM-domain proteins for ubiquitination and degradation. Here, we reveal a mechanism regulating COI1 protein levels in Arabidopsis. Genetic and biochemical analysis and in vitro degradation assays demonstrated that the COI1 protein was initially stabilized by interacting with ASK1 and further secured by assembly into SCFCOI1 complexes, suggesting a function for SCFCOI1 in the stabilization of COI1 in Arabidopsis. Furthermore, we show that dissociated COI1 is degraded through the 26S proteasome pathway, and we identified the 297th Lys residue as an active ubiquitination site in COI1. Our data suggest that the COI1 protein is strictly regulated by a dynamic balance of SCFCOI1-mediated stabilization and 26S proteasome–mediated degradation and thus maintained at a protein level essential for proper biological functions in Arabidopsis development and defense responses.
Foils of flexion: the effects of perch compliance on lizard locomotion and perch choice in the wild
Authors: Gilman Casey A. , Irschick Duncan J. 
Published: February 2013

Summary

Animals in the wild must navigate habitats that vary in structure and complexity. For arboreal animals, perch compliance (flexibility) is a common and variable characteristic, but the effects of perch compliance on arboreal behaviour and locomotion, specifically jumping, have only been examined for primates in the wild.

In this study, we observed jumping behaviour of green anole lizards (Anolis carolinensis) at a site with perches ranging from highly compliant palm leaflets to sturdy trunks and branches. We measured the characteristics, including compliance, of perches found throughout this habitat, those generally used by the green anole and those used for jumping within this population. We then compared the characteristics of these perch types to better understand how green anoles interact with compliant perches in the wild.

We found that green anoles used perches ranging across all compliances found in the habitat, but they selectively jumped from relatively non‐compliant perches. Green anoles also tended to jump farthest from relatively sturdy, low‐lying perches. Therefore, green anoles avoided the most compliant perches when jumping, likely due to the performance costs associated with compliant perch use.

In addition, we discovered that generally, perches become more compliant as they become narrower, but variance in compliance for a given diameter does not allow for the use of diameter as a proxy for compliance in this type of habitat. Thus, studies of compliance effects on small animal movement should include direct measurements of perch compliance.

We assert that perch compliance is an important habitat characteristic that influences behaviour and performance in green anoles, and likely many other small jumping animals.
Phylogenetic detection of novel Cryptomycota in an Iowa (United States) aquifer and from previously collected marine and freshwater targeted high‐throughput sequencing sets
Authors: Livermore Joshua A. , Mattes Timothy E. 
Published: February 2013

SummaryFungi are everywhere and interact with humans in countless ways, but a large group of fungi called ‘Cryptomycota’ has escaped detection until very recently. Still, the extent of diversity and ecological habits of this group remain largely unknown. We interrogated publically available 18S rRNA gene datasets, obtained via high‐throughput sequencing from marine and freshwater samples, for Cryptomycota sequences. Contrary to previous work, we found evidence of substantial Cryptomycota diversity in the marine upper water column. Additionally, we produced a sequencing set from a groundwater aquifer, an environment unrepresented among 18S rRNA gene pyrosequencing sets. The Cryptomycota community in this aquifer sample appears distinct from the community in both freshwater and marine environments with evidence of a unique aquifer clade. This study significantly expands the boundary of known Cryptomycota sequence diversity and characterizes the phylogenetic distribution of this diversity in aquatic environments. Furthermore, the approach utilized is generalizable to discovery of novel micro‐eukaryotic diversity from any lineage.
Male farmers with mental health disorders: A scoping review
Authors: Roy Philippe , Tremblay Gilles , Oliffe John L. , Jbilou Jalila , Robertson Steve 
Published: February 2013

AbstractThe issue of male farmers' mental health raises many concerns including high rates of psychological distress and suicide amid the poor uptake of health services among this subgroup. Gender is an important social determinant of health, and this paper provides an overview of connections between farming and masculinities in the context of men's mental health disorders. This scoping review summarises findings drawn from 46 studies to discuss male farmers' mental health disorders, psychosocial interventions and barriers to help‐seeking. In providing the review, recommendations are made including the need for an array of study and intervention approaches to advance the mental health and well‐being of male farmers and their families.
Public secrets in public health: Knowing not to know while making scientific knowledge
Authors: GEISSLER P. W. 
Published: February 2013

ABSTRACTUnknown knowns—or “public secrets”—may play an integral part in publicly funded medical science. In one large transnational field research site in Africa, such unknowing pertains to vital material inequalities across the relations of scientific production. These inequalities are open to experience but remain often unacknowledged in public speech and scientific texts. This silence is not usually achieved by suppressing knowledge but through linguistic convention and differentiation between places and moments of knowing and ignorance. Switching between known and unknown according to situation and interlocutor is an important, largely implicit skill that maintains relations necessary to conduct clinical research—linking bodies, lives, institutions, and technologies across differentials of resources, expertise, and power. Unknowing, then, facilitates research; and it shapes the resulting work and perpetuates the political and economic contradictions that pervade the context and the research endeavor itself. Unknowing thus poses a challenge for conventional anthropological modes of critique and engagement.
A cultural geometry: Designing political things in Sweden
Authors: MURPHY KEITH M. 
Published: February 2013

ABSTRACTIn Sweden, a long‐standing and pervasive discourse delineates the significance of design—especially “Swedish design”—within a distinctly political framework. Just as the social democratic welfare state is in large part organized to “care” for its citizens, design in Sweden is supposed to “care” for the users of everyday goods. I explore this claim in several sociocultural domains in which different aspects of Swedish design are reproduced. I also present an argument for working with design and designing as ethnographic objects of inquiry.
On love: Remaking moral subjectivity in postrehabilitation Russia
Authors: ZIGON JARRETT 
Published: February 2013

ABSTRACTLove, I argue, is a demand around which moral experience—and thus moral subjectivity—takes shape. Love entails the struggle to ethically remake oneself, and the response to its unavoidable demand has consequences for both oneself and others. I examine the moral experience of love as it was lived by two former participants in a Russian Orthodox Church–run heroin rehabilitation program in St. Petersburg. My discussion thus contributes conceptually and ethnographically to the growing literature on the anthropology of moralities.
Action of hypoxia‐inducible factor in liver and kidney from mice with Pax8‐rtTA‐based deletion of von Hippel‐Lindau protein
Authors: Mathia S. , Paliege A. , Koesters R. , Peters H. , Neumayer H.‐H. , Bachmann S. , Rosenberger C. 
Published: February 2013

AbstractAimVon Hippel‐Lindau protein (VHL) provides the degradation of hypoxia‐inducible factor (HIF). Tetracycline‐induced, Pax8‐rtTA‐based knockout of VHL (VHL‐KO) affects all renal tubules and periportal hepatocytes and leads to sustained upregulation of HIF. Here, we study the phenotype of VHL‐KO in both organs, the time course of changes, and long‐term morpho‐functional outcome.MethodsMice with doxycycline‐induced VHL‐KO and controls (CON) were followed for up to 9 months. Systemic and tissue parameters were evaluated using clinical chemistry, histology, immunohistochemistry, RT‐PCR and in situ hybridisation.ResultsAt day 3 following VHL‐KO, substantial abundance of HIF‐1α and ‐2α was detected in the nuclei of hepatocytes and renal tubular epithelia. Hypoxia, induced by bleeding anaemia, did not further augment HIF signal. Erythropoietin mRNA was detectable in hepatocytes but not in the kidney. Vascular endothelial growth factor mRNA was upregulated in kidney but not in liver. At day 7 following VHL‐KO, the renal capillary density was enhanced, reaching its maximum at day 14. Blood haemoglobin increased constantly up to day 28 (23.3 vs. 15.8 g dL−1, VHL‐KO vs. CON). Thereafter, it was kept within the normal range by weekly blood collections. Pathological changes were absent from kidney and liver 9 months after VHL‐KO.ConclusionsInducible, Pax8‐rtTA‐based deletion of VHL leads to organ‐specific expression of epithelial HIF and erythropoietin in liver and kidney without causing pathological changes. Uniform, maximal and sustained HIF activation along the renal tubule may serve to study the potential benefits of hypoxia adaptation in experimental renal injury.