bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effect of long‐term life dissatisfaction on health‐related quality of life among general population subjects
Authors: Saharinen T. , Koivumaa‐Honkanen H. , Hintikka J. , Kylmä J. , Lehto S. M. , Honkalampi K. , Haatainen K. , Viinamäki H. 
Published: March 2013

Accessible summary
Health‐related quality of life (HRQL) measures subjects perceived well‐being and functioning in physical, mental and social domains of life. In mental health nursing there is a need for improving knowledge of how life dissatisfaction, as an indicator of poor mental health, is associated and impacts on HRQL.
In the present study, both long‐term and concurrent life dissatisfaction (Life satisfaction scale; LS‐4) were found to have a strong adverse impact on HRQL in the general population.
Screening of life dissatisfaction with only four items may help mental health nurses to identify service users with poor HRQL or those at risk of it, and then investigating HRQL particularly among the dissatisfied service users would provide information on the domains and factors that most require intervention.
Monitoring of life satisfaction and HRQL in mental health nursing practice or in primary care can help nurses to cooperate with service users in promoting their mental, physical or social well‐being and functioning and in alleviating adverse consequences of disease.
AbstractThe aim of this population‐based study (n = 329) was to explore how long‐term life dissatisfaction (LS burden) and concurrent life dissatisfaction are associated with the concurrent health‐related quality of life (HRQL) (RAND‐36), and how long‐term life dissatisfaction predicts HRQL in the general population. The sum of the life satisfaction scores in 1998, 1999, 2001 (LS burden) and the concurrent life satisfaction score (LS) in 2005 were used to categorize the study participants into satisfied, intermediate and dissatisfied groups. Differences in RAND‐36 dimensions in 2005 were investigated with respect to the LS burden and concurrent life dissatisfaction. The predictive power of the LS burden for HRQL dimensions was assessed with logistic regression models. Both a high LS burden and concurrent life dissatisfaction were strongly associated with HRQL and were risk factors for poor HRQL, regardless of its dimensions. The LS burden predicted all of the RAND‐36 dimensions, except for physical functioning. Screening of life dissatisfaction can be used to identify service users whose HRQL should be further investigated. Assessment of HRQL provides information on the domains and factors that require mental health nursing intervention. This knowledge could assist mental health nurses in both the alleviation of disease consequences and promotion of well‐being of service users.
A Qualitative Analysis of Provider Barriers and Solutions to HIV Testing for Substance Users in a Small, Largely Rural Southern State
Authors: Wright Patricia B. , Curran Geoffrey M. , Stewart Katharine E. , Booth Brenda M. 
Published: March 2013

AbstractPurposeIntegrating HIV testing programs into substance use treatment is a promising avenue to help increase access to HIV testing for rural drug users. Yet few outpatient substance abuse treatment facilities in the United States provide HIV testing. The purpose of this study was to identify barriers to incorporating HIV testing with substance use treatment from the perspectives of treatment and testing providers in Arkansas.MethodsWe used purposive sampling from state directories to recruit providers at state, organization, and individual levels to participate in this exploratory study. Using an interview guide, the first and second authors conducted semistructured individual interviews in each provider's office or by telephone. All interviews were recorded, transcribed verbatim, and entered into ATLAS.ti software (ATLAS.ti Scientific Software Development GmbH, Berlin, Germany). We used constant comparison and content analysis techniques to identify codes, categories, and primary patterns in the data.FindingsThe sample consisted of 28 providers throughout the state, 18 from the substance use system and 10 from the public/ community health system. We identified 7 categories of barriers: environmental constraints, policy constraints, funding constraints, organizational structure, limited inter‐ and intra‐agency communication, burden of responsibility, and client fragility.ConclusionsThis study presents the practice‐based realities of barriers to integrating HIV testing with substance use treatment in a small, largely rural state. Some system and/or organization leaders were either unaware of or not actively pursuing external funds available to them specifically for engaging substance users in HIV testing. However, funding does not address the system‐level need for coordination of resources and services at the state level.
Pediatric nurses' postoperative pain management practices: An observational study
Authors: Twycross Alison , Finley G. Allen , Latimer Margot 
Published: March 2013

AbstractPurposeThis study was an in‐depth examination of pediatric postoperative pain care.Design and MethodsParticipant observational data were collected on the care of 10 children. Particular attention was paid to actions when pain scores were ≥5 and to the relationship between pain scores and medications administered.ResultsA pattern of care emerged of giving pain medications regularly even if they were prescribed pro re nata. Actions when pain scores were ≥5 varied. Recorded pain scores rarely guided treatment choices.Practice ImplicationsThe use of pain scores to guide treatment choices needs further debate. Future research should explore the implications of divorcing treatment from pain scores on children's pain experience.
Metabolic and Endocrine Profiles in Sick Neonatal Foals Are Related to Survival
Authors: Armengou L. , Jose‐Cunilleras E. , Ríos J. , Cesarini C. , Viu J. , Monreal L. 
Published: March 2013

BackgroundSick neonatal foals suffer from a variety of endocrine and metabolic derangements that may be related to outcome. There are several hepatic and lipid metabolism blood markers that have never been assessed in neonatal foals.ObjectivesAssess panel of endocrine and metabolic variables in group of sick and healthy neonatal foals in order to describe their relationship with diagnosis and survival.AnimalsAll neonatal foals referred to Unitat Equina‐Fundació Hospital Clínic Veterinari during 3 consecutive foaling seasons and a group of healthy foals.MethodsObservational prospective study. Blood samples were obtained on admission and, when possible, after 24–48 h of hospitalization and immediately before discharge or death. Measured variables were triglycerides, nonsterified fatty acids, glucose, creatinine, urea, γ‐glutamyltransferase, glutamate dehydrogenase (GLDH), insulin, cortisol, bile acids, and adrenocorticotropic hormone (ACTH). ACTH/cortisol and glucose/insulin ratios were calculated.ResultsUrea, creatinine, and cortisol had median concentrations in septic and nonseptic foals 2‐ to 8‐fold higher than in the control group (P < .001). Median ACTH concentration in the septic group was approximately 4 times higher than in nonseptic and control foals (P < .001). ACTH/cortisol ratio was significantly lower in sick foals compared to control foals (P < .001). A score was designed including creatinine, GLDH, and cortisol. When ≥2 of these variables were altered (P < .001), the foal had 32 times more risk of dying (OR, 31.7; 95% CI, 7.7–130.3).Conclusions and Clinical ImportancePlasma creatinine, GLDH, and cortisol should be determined in sick newborn foals on admission because of their association with survival.
Acquired Proximal Renal Tubular Dysfunction in 9 Labrador Retrievers with Copper‐Associated Hepatitis (2006–2012)
Authors: Langlois D.K. , Smedley R.C. , Schall W.D. , Kruger J.M. 
Published: March 2013

BackgroundCopper‐associated hepatitis (CAH) has been well described in Labrador Retrievers. However, the association of CAH with proximal renal tubular dysfunction in this breed has not been characterized.ObjectivesTo report clinical features, hepatic and renal histopathologic findings, tissue copper concentrations, and outcome of Labradors with CAH and proximal renal tubular disease.AnimalsNine Labrador Retrievers with renal glucosuria and biopsy‐confirmed CAH.MethodsClinical, clinicopathologic, and light microscopic findings were retrospectively reviewed. Rhodanine staining or atomic emission spectroscopy was performed on all hepatic samples and available renal tissue (4 dogs) to assess copper concentrations.ResultsEight dogs had a history of polyuria and polydipsia, and all dogs had increased serum bilirubin concentrations. Five dogs had hyperchloremic metabolic acidosis. Three dogs with acidemia had paradoxical alkalinuria. All renal specimens had increased copper concentrations. Renal tubular vacuolization, degeneration, and regeneration were observed on light microscopy. Four dogs died within 10 days of diagnosis. One dog survived 2 months; 4 dogs survived more than 1 year. In long‐term survivors, including 2 that did not undergo immediate copper chelation, resolution of renal tubular dysfunction occurred within weeks to months.Conclusions and Clinical ImportanceLabrador Retrievers with CAH can develop clinical and laboratory evidence of renal tubular dysfunction in association with increased renal copper concentrations. Given the rarity of renal tubular disorders, detection of renal glucosuria and increased ALT activity in a Labrador Retriever is suggestive of CAH. Although renal tubular dysfunction may indicate advanced disease, successful long‐term outcome is possible with a variety of therapies.
Hypercoagulability in Dogs with Protein‐Losing Nephropathy as Assessed by Thromboelastography
Authors: Lennon E.M. , Hanel R.M. , Walker J.M. , Vaden S.L. 
Published: March 2013

BackgroundDogs with protein‐losing nephropathy (PLN) are at risk of thromboembolic disease, but the mechanism leading to hypercoagulability and the population of dogs at risk are unknown.ObjectivesTo characterize thromboelastography (TEG) and its association with serum albumin (SALB),UPC, and antithrombin activity in dogs withPLN.AnimalsTwenty‐eight client‐owned dogs withPLN(urine protein:creatinine ratio [UPC] > 2.0) and 8 control dogs were prospectively enrolled in this observational study.MethodsTEGparameters, antithrombin activity, serum biochemical profiles, andUPCwere measured.TEGanalyses were run in duplicate with kaolin activation; reaction time (R), clot formation time (K), α‐angle (α), maximal amplitude (MA), and global clot strength (G) were analyzed.ResultsDogs withPLNhad lower K (P = .004), and higher α (P = .001),MA(P < .001), and G (P < .001) values than controls. No significant correlation betweenTEGparameters andUPC,SALB, or antithrombin was noted. TwelvePLNdogs (42.8%) were azotemic and 19 (67.8%) were hypoalbuminemic (SALB< 3.0 g/dL); 11 hadSALB< 2.5 g/dL.Conclusions and Clinical ImportanceThese results indicate that dogs withPLNhaveTEGvalues that demonstrate hypercoagulability compared with a control population but that antithrombin,SALB, orUPCcannot be used in isolation to predict this result. A comprehensive evaluation of the coagulation system in individual patients may be necessary to predict the point at which anti‐thrombotic therapy is indicated.
A cognitive perspective on aggressive mimicry
Authors: Jackson R. R. , Cross F. R. 
Published: March 2013

AbstractWe use the term ‘aggressive mimic’ for predators that communicate with their prey by making signals to indirectly manipulate prey behaviour. For understanding why the aggressive mimic's signals work, it is important to appreciate that these signals interface with the prey's perceptual system, and that the aggressive mimic can be envisaged as playing mind games with its prey. Examples of aggressive mimicry vary from instances in which specifying a model is straight forward to instances where a concise characterization of the model is difficult. However, the less straightforward examples of aggressive mimicry may be the more interesting examples in the context of animal cognition. In particular, there are spiders that prey on other spiders by entering their prey's web and making signals. Web invasion brings about especially intimate contact with their prey's perceptual system because the prey spider's web is an important component of the prey spider's sensory apparatus. For the web‐invading spider, often there is also a large element of risk when practising aggressive mimicry because the intended prey is also a potential predator. This element of risk, combined with exceptionally intimate interfacing with prey perceptual systems, may have favoured the web‐invading aggressive mimic's strategy becoming strikingly cognitive in character. Yet a high level of flexibility may be widespread among aggressive mimics in general and, on the whole, we propose that research on aggressive mimicry holds exceptional potential for advancing our understanding of animal cognition.
Mayan Historical Linguistics in a New Age
Authors: Law Danny 
Published: March 2013

AbstractMayan historical linguistic research has progressed at a healthy pace since the 1970s. The recent decipherment of ancient Maya hieroglyphic writing and the publication, in the last decade, of a large cohort of high quality linguistic descriptions of several Mayan languages, many of them written by native speakers of those languages, have opened a floodgate of new linguistic data that promises to revolutionize our understanding of the history of the language family. In particular, recent research has shown the Mayan region to have been a remarkably dynamic zone of language contact. Contact among Mayan languages has the potential to illuminate mechanisms and constraints on language contact between related languages. New data and attention to contact phenomena may also help clarify long‐standing disagreements about the historical relationships among Mayan languages, particularly Wastek, Tojol‐ab’al, and the language of the hieroglyphs, all of which have been an important impetus for historical linguistic research in the past decades.
Noun Phrase Structure in Article‐less Slavic Languages: DP or not DP?
Authors: Pereltsvaig Asya 
Published: March 2013

AbstractArguments for and against the DP analysis of nominals in article‐less Slavic languages are outlined and supporting evidence is reviewed. It is shown that even though both positions are not without merit, much careful consideration of facts both within and across relevant languages is still needed before the debate can be resolved. The importance of the noun phrase structure and its implications for other areas of Slavic syntax and semantics, both on the nominal and clausal levels, are pointed out.
Analysis of CIC‐associated CpG island methylation in oligoastrocytoma
Authors: Sahm F. , Lass U. , Herold‐Mende C. , von Deimling A. , Hartmann C. , Mueller W. 
Published: March 2013

AimsCombined deletion of the whole chromosomal arms 1p and 19q is a frequent event in oligodendroglial tumours. Recent identification of recurrent mutations in CIC on 19q and FUBP1 on 1p and their mutational patterns suggest a loss of function of the respective proteins. Surprisingly, oligoastrocytomas harbouring identical genetic characteristics regarding 1p/19q codeletion and frequent IDH1/2 mutations have been shown to carry CIC mutations in a significantly lower number of cases. The present study investigates whether epigenetic modification may result in silencing of CIC.MethodsAs IDH1/2 mutation‐mediated DNA hypermethylation is a prominent feature of these tumours, we analysed a set of CIC wild‐type oligoastrocytomas and other diffuse gliomas with regard to 1p/19q status for presence of CIC‐associated CpG island methylation by methylation‐specific PCR.ResultsBoth methylation‐specific PCR and subsequent bisulphite‐sequencing of selected cases revealed an unmethylated status in all samples.ConclusionDespite the hypermethylator phenotype in IDH1/2 mutant tumours and recent detection of gene silencing particularly on retained alleles in oligodendroglial tumours, hypermethylation of CIC‐associated CpG islands does not provide an alternative mechanism of functional CIC protein abrogation.
Body mass index and periodontal infection in a sample of non‐smoking older individuals
Authors: Oikarinen R , Syrjälä A‐MH , Komulainen K , Knuuttila M , Ruoppi P , Hartikainen S , Sulkava R , Ylöstalo P 
Published: March 2013

ObjectiveThe aim of this study was to investigate the association between BMI and periodontal infection in a sample of non‐smoking individuals aged 75 years or older.Subjects and MethodsThe study sample included 157 non‐smoking dentate persons (110 women, 47 men, mean age 80.6 years) belonging to the Geriatric Multidisciplinary Strategy for the Good Care of Older People study in Kuopio, Finland. The data were gathered by interview together with geriatric and oral clinical examination. The outcome variable was the number of teeth with periodontal pockets measuring 4 mm or more in depth. Poisson regression models were used to estimate relative risk (RR) and 95% confidence intervals (CI).ResultsAfter adjustment for confounding factors, the relative risk for the number of teeth with deepened periodontal pockets (≥4 mm) was 0.7 (CI: 0.6–0.9) among those with a BMI 25–29.99 and 1.1 (CI: 0.8–1.4) among those with a BMI ≥30, compared with those having a BMI <25.ConclusionWithin the limitations of this study, including small sample size, possibility of confounding and other biases, the results do not provide evidence that elevated body weight would be a risk for periodontal infection among older people.
Lumbar Zygapophyseal Pain During Extension‐Based Stabilization Protocol Following Lumbar Transdiscal Biacuplasty
Authors: Sayal Puneet K , Desai Mehul J 
Published: March 2013

AbstractIntroductionTransdiscal biacuplasty (TDB) is a minimally invasive procedure for the treatment of lumbar discogenic pain. Theoretically, TDB ablates the aberrant ingrowth of nerve fibers beyond the outer third of the annulus fibrosis of the lumbar intervertebral disk and treats annular tears via collagen reformation. Typically, recovery involves a robust rehabilitation protocol that emphasizes lumbar stabilization exercises, focusing on extension maneuvers while also strengthening the multifidi and transverse abdominus. New‐onset postprocedural pain during recovery may occur; evaluation of nondiscogenic causes should be considered. We report 3 of 12 patients who developed zygapophyseal‐mediated pain during the recovery period.CasesThree of 12 patients who underwent TDB over a 1‐year period, developed zygapophyseal‐mediated back pain at the level of the original discogenic pathology. All three underwent unilateral intra‐articular zygapophyseal injections with resolution of their new‐onset symptoms.DiscussionNovel postprocedural low back pain should provoke re‐evaluation of potential etiologies such as persistent discogenic pathology, zygapophyseal or sacroiliac joint involvement, and other mechanical sources of pain. We postulate that extension maneuvers during rehabilitation, combined with lumbar bracing in extension, inadvertently triggered and potentially exacerbated pre‐existing zygapophyseal irritation. The clinical implication of this scenario is novel distracting pain, caused by an alternative etiology to the original discogenic pain, and may present a confounder to the assessment of the efficacy of TDB.
Differentiating the wild or farmed origin ofMediterranean fish: a review of tools for sea bream and sea bass
Authors: Arechavala‐Lopez Pablo , Fernandez‐Jover Damian , Black Kenneth D. , Ladoukakis Emmanuel , Bayle‐Sempere Just T. , Sanchez‐Jerez Pablo , Dempster Tim 
Published: March 2013

AbstractBased on the fact that farmed fish experience different environments, stocking densities and feeding regimes compared with wild fish, several techniques have been developed to discriminate the wild or farmed origin of fish. These techniques quantify differences between genetics, chemical characteristics, fatty acid compositions, trace elements, pollutants, stable isotopes, morphology and organoleptic characteristics. Gilthead sea bream and European sea bass are the most important marine fish in Mediterranean aquaculture and are highly appreciated by commercial and recreational fisheries. A total of 60 studies that used techniques to discriminate farmed from wild fish for sea bream and sea bass form the basis of this review. The most common technique used differences in the lipid and fatty acid composition of fish. Many of these studies dealt with food science and product quality, rather than tracing escapees. A wide range of identification tools is useful in determining the correct origin of captures and proper labelling of marketed fish. External appearance and morphometry are useful for rapid assessments and can be achieved with high accuracy and little cost, especially for sea bream. This makes these methods suitable for detecting large and recent escape events, applicable in fisheries studies, and for ensuring that wild and farmed fish are separated in the marketplace. Techniques using differences in chemical or genetic composition are more useful for environmental monitoring, as they have higher accuracy and can detect escapees long after the escape incident. Regulatory bodies should legislate protocols that describe the technique(s) that must be applied in specific circumstances.
Moult inhibiting hormone: a new approach to the discovery and design of growth promoters in crustaceans?
Authors: Shrivastava Sajal , Princy Adline 
Published: March 2013

AbstractSeveral chemicals have been tested as growth promoters in aquaculture but they cannot be endorsed for commercial processes due to their residual effects in the body of prawns, lobsters and crabs. The concern over environmental hazard, human health and food safety have led to a search for alternative growth promoters significantly to improve the growth of crustaceans with no such effects. Neurohormones, regulatory signalling molecules of crustaceans that coordinate multiple developmental and physiological processes, are major determinants underlying phenotypic integration. Competitive inhibitors for the moult inhibiting hormone receptor are expected to have a direct growth promoting effect on crustaceans by direct involvement in interference with the receptor in the Y‐organ, which can cause a surge the production of ecdysteroids. Competitive inhibitors therefore can be regarded as growth promoters in crustacean fishery in addition to various other benefits. This review emphasizes the manifold effects of moult inhibiting hormone, a most versatile animal hormone, with an emphasis on the target sites and competitive inhibition.