bluuebunny/crossref_metadata_2025_split huggingface dataset:
PELATIHAN DIGITAL MARKETING PADA SISWA SMKS MULTI MEKANIK MASMUR PEKANBARU
Authors: Irwanda Ahmad Ade , Abiyus Wentisasrapita , Wiza Fana , Joko Suprianto  , Wilbert Sianturi  
Published: July 2024

Digital marketing adalah bentuk promosi yang memanfaatkan teknologi digital. Internet marketing adalah salah satu jenis pemasaran digital yang menggunakan media elektronik atau internet (emarketing). SMKS Multi Mekanik Masmur Pekanbaru adalah Sekolah Swasta di kota Pekanbaru. Strategi yang selama ini digunakan adalah sudah berbasis digital namun belum dilakukan secara optimal. Selain itu, SMKS Multi Mekanik Masmur Pekanbaru menggunakan media sosial seperti Facebook, Instagram, dan YouTube untuk meningkatkan promosi, namun hanya terbatas. Tim pengabdian memberikan pelatihan kepada Siswa SMKS Multi Mekanik Masmur Pekanbaru tentang Pemahaman mengenai Digital Marketing, Platform untuk Digital Marketing, dan Pemasaran dengan Digital Marketing dari permasalahan mitra diatas. Sasaran dari inisiatif Pengabdian Kepada Masyarakat tahun ini adalah peserta pelatihan (Siswa SMKS Multi Mekanik Masmur Pekanbaru). Siswa harus dapat menggunakan dan mengoptimalkan media sosial untuk meningkatkan sekolah.
PENINGKATAN KOMPETENSI GURU MATA PELAJARAN SEKOLAH MENENGAH KEJURUAN NEGERI 3 BENGKALIS DALAM IMPLEMENTASI KURIKULUM MERDEKA
Authors: Syahtriatna Djusar  , Elvira Asril  , Ahmad Zamsuri  , Febrizal Alfarasy Syam  
Published: July 2024

Kurikulum Merdeka bertujuan agar siswa dapat aktif dalam pembelajaran, siap menghadapi perubahan, dan terlibat dalam pengembangan masyarakat secara keseluruhan. Dalam rangka mendukung Implementasi Kurikulum Merdeka, tujuan utama pengabdian kepada masyarakat ini adalah meningkatkan kompetensi para guru mata pelajaran Sekolah Menengah Kejuruan Negeri 3 Bengkalis dalam Implementasi Kurikulum Merdeka. Fokus utama pelatihan adalah memperdalam pemahaman, keterampilan dan sikap guru terhadap Kurikulum Operasional Satuan Pendidikan (KOSP), Pembelajaran dan Asesmen, serta pelaksanaan Projek Penguatan Profil Pelajar Pancasila (P5). Metode pelaksanaan kegiatan dalam bentuk workshop. Rencana pelaksanaan dimulai dengan: identifikasi kebutuhan guru; penyusunan materi pelatihan yang relevan dan aplikatif; implementasi workshop dan sesi praktis secara bertahap dengan pendekatan praktik; evaluasi: pengukuran peningkatan pemahaman guru terkait materi, sebelum dan sesudah pelatihan. Hasil kuisioner awal terhadap 25 orang guru sebagai peserta, didapatkan rata-rata hasil penilaian pemahaman dan pengetahuan awal adalah sebesar 24.48 /30, artinya dari 30 pertanyaan, maka yang betul hanya sekitar 25 jawaban dan masih ada sekitar 5 jawaban pertanyaan yang salah. Setelah dilakukan refleksi dan evaluasi, dengam melakukan kuisioner akhir dengan pertanyaan yang sama, dan dengan mengamati dan menilai produk yang dihasilkan peserta di akhir kegiatan, maka dapat disimpulkan bahwa telah terdapat peningkatan pengetahuan dan pemahaman peserta terkait dengan KOSP, Pembelajaran dan Asesmen, P5, dengan hasil kusioner akhir sebesar 29/30, artinya dari 30 pertanyaan, rata-rata hanya 1 pertanyaan yang masih belum tepat dijawab oleh setiap peserta.
Implementation of Restorative Justice in a Customary Court in Rejang Lebong District, Bengkulu, Indonesia: A Maqāṣid Al-Sharī‘ah Review
Authors: Andiko Toha , Nurdin Zurifah , Efrinaldi Efrinaldi 
Published: July 2024

This paper aims at analyzing the form of restorative justice implemented in a customary court in Rejang Lebong District, and maqāṣid al-sharī‘ah review of the customary court. This type of research is qualitative with sociological-juridical approach. Data sources were literature, observation, in-depth interviews and documentation. The data analysis technique used qualitative descriptive analysis. This study showed that the form of restorative justice applied in the process customary court in Rejang Lebong prioritizes deliberation and peace between the parties. In terms of sanctions, compensation is based on the request of the victim and the consent of the perpetrator coupled with customary fines. Although there is a provision for customary fines, in practice, the judge determines the amount according to the ability of the perpetrator. In terms of maqāṣid al-sharī‘ah, the process prioritizing deliberation and peace is relevant to the objective of evading mafsadat, which is to reduce the anger and resentment of the victim or their family. Based on the form of sanctions applied, there is a benefit to maintain the existence of religion, property, soul, offspring, and honor. The sanctions prioritizing restoration, harmonious relations, deterrent effects, and learning for the community, have mutual functions of zawajir and ta'dib. This customary justice model that combines restorative justice and local wisdom can possibly be an alternative dispute resolution to non-litigation case settlement.
The Implications of the Countercyclical COVID-19 Policy on the Performance of Rural Banks and Sharia Rural Banks in Indonesia
Authors: Iska Syukri , Nofrivul Nofrivul , Jaya Indra , Nengsih Ifelda , Renie Elsy 
Published: July 2024

This study investigated the impact of the Indonesian government policies implemented through POJK No. 11/POJK.03/2020 on the banking performance of Rural Bank (BPR) and Sharia Rural Bank (BPRS) after the implementation of countercyclical policies to stimulate the country's economy affected by the COVID-19 pandemic in Indonesia between March and December 2020. Mixed method approaches were applied to analyze the contributing factors to different performances between seven Rural Banks and seven Sharia Rural Banks in West Sumatra that were randomly selected through purposive sampling based on proportionate assets. The quantitative data were financial statements sourced from the OJK 2021 Publications, and the qualitative data were collected from in-depth interviews with eight Directors of Rural Banks and Sharia Rural Banks selected from the snowball sampling. Analyzing Indonesian government policies embodied in the countercyclical policy, we found that banking policies in Sharia Rural Banks outperformed those of conventional Rural Banks, as reflected by the average ROA (1.16% vs 1.33%), ROE (0.09% vs. 0.08%), and NPL (6.67% vs. 6.82%). The contributing factor to this gap was the different internal policies of each institution to translate the countercyclical concept based on the operational principles, such as the interest rate of Rural Bank and margin of Sharia Rural Bank despite the fact that both banks shared practice in the principal deferment and credit extension.
Manajemen Risiko pada Perusahaan Asuransi Syariah di Indonesia
Authors: Aliefah Aniesatun Nurul , Marsatiya Hanifah , Kusumaningrum Putri , Amrulloh Akrom 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui bagaimana manajemen risiko underwriting pada perusahaan asuransi Syariah di Indonesia. Penelitian ini menggunakan pendekatan kualitatif deskriptif yaitu berdasarkan data sekunder yang diperoleh dari buku, jurnal dan dokumen pendukung lainnya yang relevan dengan penelitian yang dilakukan. Hasil penelitian ini menunjukkan bahwa manajemen risiko pada asuransi Syariah merupakan salah satu aspek penting yang harus ada untuk mencapai tujuan suatu perusahaan. Manajemen risiko merupakan kumpulan tindakan yang digunakan untuk menemukan, mengukur, mengawasi dan mengelola risiko yang akan muncul di masa depan pada lembaga keuangan bukan bank. Adapun jenis atau kategori risiko diantaranya yaitu Increasing risk, Decreasing Risk, dan Constant Extra Risk. Proses seleksi risiko (underwriting) yang dilalui perusahaan asuransi syariah meliputi pengajuan surat permintaan, analisis risiko, kemudian penerbitan polis.

Kata Kunci : Manajemen Risiko, Asuransi Syariah Underwriting
MEMORY AND TIME IN OLES ILCHENKO’S PHOTOPOETRY
Authors: Рязанцева Тетяна 
Published: July 2024

The paper considers new creative approaches to the established types of poetry. Building on the theoretical definitions, taxonomies and observations formulated in the works of Aleida Assmann, Roland Barthes, Nina Chamata, Robert Crawford and Norman McBeath, Michael Nott, Irina Rajewski, James Smith, Susan Sontag, et al., the research argues that the artistic practices of photopoetry (“a form of photo-text that takes, for its primary components, poetry and photography”, Michael Nott) offer new ways to interpret certain topics of metaphysical poetry.
The material for analysis is taken from a black and white photo-text book “Some Dreams or Kyiv That No Longer Exists” (2007) by a Geneva-based Ukrainian poet and artist Oles Ilchenko. The detailed analysis of it seeks to clarify the structural, stylistic, and semantic characteristics of Ilchenko’s photopoetry. The special attention is paid to the mechanics of cyclization, forms of intermedial interactions, and types of artistic collaboration in this project. It is also noted that the interpretative co-operation with the audience here depends on the readers/viewers’ personal memories and emotions evoked by these photographs and poems.
Focusing on the motifs of memory, nostalgia, and transience of life, Ilchenko’s photopoetic cycle explores the metaphysical theme of Death and Time in its connection with the urban space of Kyiv. This project demonstrates that the long form photopoetry provides the 21st century author with some efficient creative instruments to interpret the realities “of peculiar kind” (James Smith), such as time and memory. The contrasting combination of verbal and visual elements in this book creates an effect of double visualization, which accentuates the dynamics and dramatic tension between the poems and the images. The cyclic composition of texts paired with the fragmented and modified photographs transforms the real urban space into a powerful metaphor of memory and personal loss.
Short-term cryoprotectant-free cryopreservation at −20°C does not affect the viability and regenerative capacity of nanofat
Authors: Limido Ettore , Weinzierl Andrea , Ampofo Emmanuel , Harder Yves , Menger Michael D. , Laschke Matthias W. 
Published: July 2024

Nanofat is an autologous fat derivative with high regenerative activity, which is usually administered immediately after its generation by mechanical emulsification of adipose tissue. For its potential repeated use over longer time, we herein tested whether cryopreservation of nanofat is feasible. For this purpose, the inguinal fat pads of donor mice were processed to nanofat, which was i) frozen and stored in a freezer at −20°C, ii) shock frozen in liquid nitrogen with subsequent storage at −80°C or iii) gradually frozen and stored at −80°C. After 7 days, the cryopreserved nanofat samples were thawed and immunohistochemically compared with freshly generated nanofat (control). Nanofat frozen and stored at −20°C exhibited the lowest apoptotic rate and highest densities of blood and lymph vessels, which were comparable to those of control. Accordingly, nanofat cryopreserved at −20°C or control nanofat were subsequently fixed with platelet-rich plasma in full-thickness skin defects within dorsal skinfold chambers of recipient mice to assess vascularization, formation of granulation tissue and wound closure by means of stereomicroscopy, intravital fluorescence microscopy, histology and immunohistochemistry over 14 days. These analyses revealed no marked differences between the healing capacity of wounds filled with cryopreserved or control nanofat. Therefore, it can be concluded that cryopreservation of nanofat is simply feasible without affecting its viability and regenerative potential. This may broaden the range of future nanofat applications, which would particularly benefit from repeated administration of this autologous biological product.
Burkholderia cepacia in cystic fibrosis children and adolescents: overall survival and immune alterations
Authors: Shmarina Galina , Pukhalskaya Daria , Shmarin Vassiliy , Semykin Sergey , Avakyan Lusine , Krasovsky Stanislav , Goryainova Anastasia , Kostyuk Svetlana , Zinchenko Rena , Kashirskaya Nataliya 
Published: July 2024

BackgroundIn current literature there are only scarce data on the host inflammatory response during Burkholderia cepacia complex (Bcc) persistence. The primary objective of the present research was to carry out cross-sectional analyses of biomarkers and evaluate disease progression in cystic fibrosis (CF) patients with chronic Bcc infection and pathogen-free ones. The secondary aim was to assess prospectively overall survival of the study participants during up to 8 years of follow-up.MethodsThe study included 116 paediatric patients with CF; 47 CF patients were chronically infected with Bcc, and 69 individuals were Bcc free. Plasma and sputum biomarkers (neutrophil elastase, MMP-8, MMP-9, MMP-12, IL-2, IL-4, IL-6, IL-8, IL-10, IL-18, IL-22, IL-23, IL-17, IFN-γ, TGFβ1, TNF-α) were analysed using commercially available kits. Besides, inhibitory effect of dexamethasone on proliferative response of PHA-stimulated peripheral blood lymphocytes had been assessed.ResultsBcc infected patients did not differ from Bcc free ones in demographic and clinical parameters, but demonstrated an increased rate of glucose metabolism disturbances and survival disadvantage during prolong follow-up period. Biomarkers analyses revealed elevated TNF-α and reduced IL-17F levels in sputum samples of Bcc infected patients. These patients also demonstrated improvement of peripheral blood lymphocyte sensitivity to steroid treatment and reduction in plasma pro-inflammatory (IL-17F and IL-18) and anti-inflammatory (TGFβ1 and IL-10) cytokine concentrations.ConclusionsReduction in IL-17F levels may have several important consequences including increase in steroid sensitivity and glycemic control disturbances. Further investigations are needed to clarify the role of IL-17 cytokines in CF complication development. Low plasma TGFβ1 and IL-10 levels in Bcc infected group may be a sign of subverted activity of regulatory T cells. Such immune alterations may be one of the factors contributing to the development of the cepacia syndrome.
Application of metagenomic next-generation sequencing for rapid molecular identification in spinal infection diagnosis
Authors: Lv Hui , Liao Sheng , Shi Zhenzhen , Guo Yuan , Zhou JianHong , Chen Hui , Luo Fei , Xu JianZhong , Zhang ZhongRong , Zhang ZeHua 
Published: July 2024

ObjectiveThis study aimed to determine the sensitivity and specificity of metagenomic next−generation sequencing (mNGS) for detecting pathogens in spinal infections and to identify the differences in the diagnostic performance between mNGS and targeted next−generation sequencing (tNGS).MethodsA total of 76 consecutive patients with suspected spinal infections who underwent mNGS, culture, and histopathological examinations were retrospectively studied. The final diagnosis of the patient was determined by combining the clinical treatment results, pathological examinations, imaging changes and laboratory indicators. The sensitivity and specificity of mNGS and culture were determined.ResultsThe difference between the two detection rates was statistically significant (p &lt; 0.001), with mNGS exhibiting a significantly higher detection rate (77.6% versus 18.4%). The average diagnosis time of mNGS was significantly shorter than that of bacterial culture (p &lt; 0.001, 1.65 versus 3.07 days). The sensitivity and accuracy of mNGS were significantly higher than that of the culture group (p &lt; 0.001, 82.3% versus 17.5%; 75% versus 27.6%), whereas the specificity of mNGS (42.9%) was lower than that of the culture group (p &gt; 0.05, 42.9% versus 76.9%). The sensitivity, specificity, accuracy, and positive predictive value (PPV) of pus were higher than those of tissue samples for mNGS, whereas for culture, the sensitivity, specificity, accuracy, and PPV of tissue samples were higher than those of pus. tNGS demonstrated higher sensitivity and accuracy in diagnosing tuberculosis (TB) than mNGS (80% versus 50%; 87.5% versus 68.8%).ConclusionmNGS for spinal infection demonstrated better diagnostic value in developing an antibiotic regimen earlier, and it is recommended to prioritize pus samples for testing through mNGS. Moreover, tNGS outperformed other methods for diagnosing spinal TB and identifying antibiotic-resistance genes in drug-resistant TB.
Strategic management of internal employer branding – guerilla strategies to engage and retain top employees in a challenging workforce environment
Authors: Barbulescu Florentina-Mihaela , Vasiluță-Ștefănescu Marius , Stoicov Ionela , Coman Claudiu , Coman Ecaterina 
Published: July 2024

IntroductionIn a globalized and constantly evolving employment environment, it is imperative that organizations cultivate effective employer branding strategies to maintain competitiveness and attractiveness. These would allow them to obtain unique advantages in the market but also support for the internal employer brand. Despite the critical role of employer branding in attracting and retaining top talent, there remains a gap in understanding its relationship to HRM practices and employee perceptions of those practices. The purpose of this research was to investigate the correlation between human resources management practices and employer branding measured through organizational attractiveness and seen from the employees’ perspective. Additionally, to find out if there is a significant difference between the private and public sector in terms of the perception of HRM practices influencing organizational attractiveness.MethodsA questionnaire was applied to 800 respondents, employed in various positions in private and public sector organizations in western Romania. Two scales were applied to evaluate human resources management practices and the employer’s attractiveness from the employees’ perspective.ResultsFindings indicate a direct and positive relation between HRM practices and organizational attractiveness, with particular emphasis on performance appraisal practice, training and development, and work-life balance practices. When it comes to private sector, the significant practices influencing organizational attractiveness are performance appraisal, safety, and work-life balance practices, whereas in the public sector we have training-development and performance appraisal practices.DiscussionThese results underline the role of human resource management in strengthening internal support for the employer brand and increasing overall employer attractiveness. The more appropriate human resource management practices are in the perception of employees, the more attractive the organization is perceived as an employer.
The levels of circulating cytokines and risk of neuromyelitis optica spectrum disorder: a Mendelian randomization study
Authors: Ma Xue , Wang Yao , Chen Xin , Guo Jun 
Published: July 2024

BackgroundNeuromyelitis optica spectrum disorder (NMOSD) is an inflammatory autoimmune disease affecting the central nervous system (CNS). NMOSD pathogenesis involves systemic inflammation. However, a causal relationship between circulating cytokine levels and NMOSD remains unclear.MethodsMendelian randomization (MR) approaches were used to investigate the potential association between genetically determined circulating 19 inflammatory cytokines and 12 chemokines levels and the risk of developing NMOSD.ResultsAfter Bonferroni correction, the risk of aquaporin 4-antibody (AQP4-ab)-positive NMOSD was suggested to be causally associated with the circulating levels of three cytokines, including interleukin (IL)-4 [odds ratio (OR): 11.01, 95% confidence interval (CI): 1.16–104.56, P = 0.037], IL-24 (OR: 161.37; 95% CI: 2.46–10569.21, P = 0.017), and C-C motif chemokine 19 (CCL19) (OR: 6.87, 95% CI: 1.78–26.93, P = 0.006).ConclusionThese findings suggest that a genetic predisposition to higher levels of IL-4, IL-24, and CCL19 may exert a causal effect on the risk of AQP4-ab-positive NMOSD. Further studies are warranted to clarify how these cytokines affect the development of AQP4-ab-positive NMOSD.
A novel prognostic signature related to programmed cell death in osteosarcoma
Authors: Jiang Yu-Chen , Xu Qi-Tong , Wang Hong-Bin , Ren Si-Yuan , Zhang Yao 
Published: July 2024

BackgroundOsteosarcoma primarily affects children and adolescents, with current clinical treatments often resulting in poor prognosis. There has been growing evidence linking programmed cell death (PCD) to the occurrence and progression of tumors. This study aims to enhance the accuracy of OS prognosis assessment by identifying PCD-related prognostic risk genes, constructing a PCD-based OS prognostic risk model, and characterizing the function of genes within this model.MethodWe retrieved osteosarcoma patient samples from TARGET and GEO databases, and manually curated literature to summarize 15 forms of programmed cell death. We collated 1621 PCD genes from literature sources as well as databases such as KEGG and GSEA. To construct our model, we integrated ten machine learning methods including Enet, Ridge, RSF, CoxBoost, plsRcox, survivalSVM, Lasso, SuperPC, StepCox, and GBM. The optimal model was chosen based on the average C-index, and named Osteosarcoma Programmed Cell Death Score (OS-PCDS). To validate the predictive performance of our model across different datasets, we employed three independent GEO validation sets. Moreover, we assessed mRNA and protein expression levels of the genes included in our model, and investigated their impact on proliferation, migration, and apoptosis of osteosarcoma cells by gene knockdown experiments.ResultIn our extensive analysis, we identified 30 prognostic risk genes associated with programmed cell death (PCD) in osteosarcoma (OS). To assess the predictive power of these genes, we computed the C-index for various combinations. The model that employed the random survival forest (RSF) algorithm demonstrated superior predictive performance, significantly outperforming traditional approaches. This optimal model included five key genes: MTM1, MLH1, CLTCL1, EDIL3, and SQLE. To validate the relevance of these genes, we analyzed their mRNA and protein expression levels, revealing significant disparities between osteosarcoma cells and normal tissue cells. Specifically, the expression levels of these genes were markedly altered in OS cells, suggesting their critical role in tumor progression. Further functional validation was performed through gene knockdown experiments in U2OS cells. Knockdown of three of these genes—CLTCL1, EDIL3, and SQLE—resulted in substantial changes in proliferation rate, migration capacity, and apoptosis rate of osteosarcoma cells. These findings underscore the pivotal roles of these genes in the pathophysiology of osteosarcoma and highlight their potential as therapeutic targets.ConclusionThe five genes constituting the OS-PCDS model—CLTCL1, MTM1, MLH1, EDIL3, and SQLE—were found to significantly impact the proliferation, migration, and apoptosis of osteosarcoma cells, highlighting their potential as key prognostic markers and therapeutic targets. OS-PCDS enables accurate evaluation of the prognosis in patients with osteosarcoma.