bluuebunny/crossref_metadata_2025_split huggingface dataset:
Tunable and strong circular dichroism mediated with graphene-Weyl semimetal planar scheme
Authors: Xu Sicheng , Yu Siyao , Qian Liming , Zheng Gaige 
Published: July 2024

Abstract
Strong circular dichroism (CD) has been observed in Weyl semimetals (WSMs) because of the extremely large gyrotropic optical response. However, traditional proposals cannot tune the wavelength of CD peaks continuously without changing the geometric parameters or external magnetic field, which limits the practical application. This study presents a lithography-free platform exhibits near-unity CD in a WSM-graphene-dielectric structure. It is theoretically shown that the proposal possesses different reflectance properties for right-hand circular polarization and left-hand circular polarization light in the mid-infrared range. The merits of the wide-angular chiral capacity of CP waves can also be maintained. The CD of the chiral structure can be tuned not only by adjusting the structural parameters, but also the chemical potential of graphene, which may also facilitate the design of more efficient chiral optical devices.
Rhodes the Island, Rhodes the Polis: Religious Community and Synoecism
Authors: Zachhuber Juliane 
Published: July 2024

AbstractThis chapter explores the political shifts that the communities of Rhodes underwent in the synoecism of the late fifth century bc and how these established a new sense of regional and religious identity. It considers the evidence for pan-Rhodian identity and religion before this period, particularly the foundation myths, and explores their reception in the political climate of the fifth century bc. Next it lays out the sparse evidence for the Rhodian synoecism itself, and traces its impact on the religious calendar, the religious dimension of founding a new city and the introduction of new gods and cults, and finally the effect of social and political shifts on religious offices and organization.
Religious Personnel
Authors: Zachhuber Juliane 
Published: July 2024

AbstractThis chapter brings together the substantial evidence for Rhodian priests and considers the meaning and function of these various religious offices for individuals and their families, and conversely, what it was that they brought to the community and its gods. In doing so, it touches on a number of key themes of late Classical and Hellenistic religion and its intersection with society: economies of cult and their development to be dependent increasingly on private wealth and benefactions; the religious and social profiles of priests and their selection processes; the locus of religious authority or knowledge in a community; and the role of priests as mediators between gods and polis.
Caregivers’ Internet-Delivered Insomnia Intervention Engagement and Benefit: SHUTi-CARE Trial Primary Quantitative Analysis
Authors: Shaffer Kelly M , Ritterband Lee M , You Wen , Mattos Meghan K , Buysse Daniel J , Glazer Jillian V , Klinger Julie , Donovan Heidi 
Published: July 2024

Abstract

Background
Delivering insomnia treatment by the Internet holds promise for increasing care access to family caregivers, but their ability to adhere to and benefit from such fully-automated programs has not been rigorously tested.

Purpose
This fully-powered, single-group trial tested whether characteristics of the caregiving context influence high-intensity caregivers’ engagement with and benefit from an empirically validated Internet intervention for insomnia.

Methods
At baseline, caregivers providing unpaid time- and responsibility-intensive care who reported insomnia (N = 100; age M = 52.82 [SD = 13.10], 75% non-Hispanic white, 66% ≥college degree) completed questionnaires about caregiving context and sleep, then 10 prospectively-collected online daily sleep diaries. Caregivers then received access to SHUTi (Sleep Healthy Using the Internet), which has no caregiver-specific content, for 9 weeks, followed by post-assessment (questionnaires, diaries). Engagement was tracked by the SHUTi delivery system.

Results
Sixty caregivers completed SHUTi, 22 initiated but did not complete SHUTi, and 18 did not initiate SHUTi. Caregivers were more likely to use SHUTi (than not use SHUTi) when their care recipient (CR) had worse functioning, and were more likely to complete SHUTi when supporting more CR activities of daily living (ADL; ps &lt; .03). Higher caregiver guilt, more CR problem behaviors, and being bedpartners with the CR related to more improved sleep outcomes, whereas supporting more CR instrumental ADL related to less improvement (ps &lt; .05).

Conclusions
Factors associated with greater caregiving burden, including greater CR impairment and caregiving guilt, were generally associated with better engagement and outcomes. Caregivers with substantial burdens can adhere to and benefit from a fully automated insomnia program without caregiver-specific tailoring.
Tobacco Cessation Interventions in Non-Respiratory Cancers: A Systematic Review With Meta-analysis of Randomized Controlled Trials
Authors: Dhumal Trupti , Kelly Kimberly M , Khadka Safalta , Kelley George A , Kamal Khalid M , Scott Virginia G , Hogan Thomas F , Harper Felicity W K 
Published: July 2024

Abstract

Background
Considering the high rates of persistent tobacco use, effective cessation interventions are needed for cancer patients and caregivers. Despite the need, there is a significant lack of research on tobacco cessation, especially for non-respiratory cancers (breast, prostate, colorectal, cervical, and bladder cancer).

Purpose
The objective was to evaluate tobacco use and tobacco cessation interventions among patients and caregivers for non-respiratory cancers.

Methods
Randomized controlled trials assessing tobacco cessation interventions were identified. Five electronic databases were searched in accordance with the Preferred Reporting Items for Systematic reviews and Meta-analyses guidelines through July 2023. Studies exclusive to lung, oral, thoracic, and head and neck cancers were excluded. Effect sizes were estimated; risk of bias was assessed.

Results
Of 3,304 studies, 17 were included. Interventions included behavioral (n = 6), pharmacotherapy (n = 2), and a combination (n = 9) treatment. Eight studies included a health behavior model; mean behavioral change techniques were 5.57. Pooled magnitude of the odds of cessation was positive and significant (odds ratio = 1.24, 95% confidence interval [Lower Limit 1.02, Upper Limit 1.51]) relative to usual care/placebo. Cumulative meta-analysis examined the accumulation of results over-time and demonstrated that studies have been significant since 2020. Two studies included caregivers’ who were involved in the provision of social support.

Conclusions
Current interventions have the potential to reduce tobacco use in non-respiratory cancers. Results may be beneficial for promoting tobacco cessation among non-respiratory cancers. There is a considerable lack of dyadic interventions for cancer survivors and caregivers; researchers are encouraged to explore dyadic approaches.
Targeted Treatment Reverses Increased Left Cardiac Work in Unilateral vs. Bilateral Primary Aldosteronism
Authors: Kokko Eeva , Viukari Marianna , Koskela Jenni K , Choudhary Manoj Kumar , Matikainen Niina , Mustonen Jukka , Nevalainen Pasi I , Pörsti Ilkka 
Published: July 2024

Abstract

BACKGROUND
The incidence of cardiovascular complications may be higher in unilateral than bilateral primary aldosteronism (PA). We compared noninvasive hemodynamics after targeted therapy of bilateral vs. unilateral PA.

METHODS
Adrenal vein sampling was performed, and hemodynamics recorded using radial artery pulse wave analysis and whole-body impedance cardiography (n = 114). In 40 patients (adrenalectomy n = 20, spironolactone-based treatment n = 20), hemodynamic recordings were performed after 33 months of PA treatment.

RESULTS
In initial cross-sectional analysis, 51 patients had bilateral and 63 unilateral PA. The mean ages were 50.6 and 54.3 years (P = 0.081), and body mass indexes 30.3 and 30.6 kg/m2 (P = 0.724), respectively. Aortic blood pressure (BP) and cardiac output did not differ between the groups, but left cardiac work was ~10% higher in unilateral PA (P = 0.022). In the follow-up study, initial and final BPs in the aorta were not significantly different, while initial cardiac output (+13%, P = 0.015) and left cardiac work (+17%, P = 0.009) were higher in unilateral than bilateral PA. After median treatment of 33 months, the differences in cardiac load were abolished, and extracellular water volume was reduced by 1.3 and 1.4 l in bilateral vs. unilateral PA, respectively (P = 0.814).

CONCLUSIONS
These results suggest that unilateral PA burdens the heart more than bilateral PA, providing a possible explanation for the higher incidence of cardiac complications in unilateral disease. A similar reduction in aldosterone-induced volume excess was obtained with targeted surgical and medical treatment of PA.
A Non-Ideal Theory of Knowledge
Authors: McKenna Robin 
Published: July 2024

AbstractIn her article in this volume Linda Martín Alcoff makes the case for a form of political epistemology that denaturalizes, in the sense of historically and socially situating, procedures of knowledge production and distribution. She pursues this project via a discussion of three twentieth-century thinkers (Horkheimer, Habermas and Foucault) who, she argues, pursued this form of political epistemology, albeit in different ways, and to different ends. In this article I pursue a similar project, but within a different tradition, one that grows out of naturalized epistemology.
Discovery of an antimalarial compound, burnettiene A, with a multidrug-sensitive Saccharomyces cerevisiae screening system based on mitochondrial function inhibitory activity
Authors: Kimishima Aoi , Nishitomi Atsuka , Tsuruoka Iori , Sakai Katsuyuki , Hokari Rei , Honsho Masako , Honma Sota , Ono Yuki , Kondo Naozumi , Tsutsumi Hayama , Kikuchi Yuta , Tokiwa Toshiyuki , Kojima Hiroki , Higo Mayuka , Nonaka Kenichi , Inahashi Yuki , Iwatsuki Masato , Fuji Shin-ichi , Jang Jun-Pil , Jang Jae-Hyuk , Chinen Takumi , Usui Takeo , Asami Yukihiro 
Published: July 2024

ABSTRACT
In this paper, we describe our discovery of burnettiene A (1) as an antimalarial compound from the culture broth of Lecanicillium primulinum (current name: Flavocillium primulinum) FKI-6715 strain utilizing our original multidrug-sensitive yeast system. This polyene-decalin polyketide natural product was originally isolated as an antifungal active compound from Aspergillus burnettii. However, the antifungal activity of 1 has been revealed in only one fungal species, and the mechanism of action of 1 remains unknown. After the validation of mitochondrial function inhibitory of 1, we envisioned a new antimalarial drug discovery platform based on mitochondrial function inhibitory activity. We evaluated antimalarial activity and 1 showed antimalarial activity against Plasmodium falciparum FCR3 (chloroquine sensitive) and the K1 strain (chloroquine resistant). Our study revealed the utility of our original screening system based on a multidrug-sensitive yeast and mitochondrial function inhibitory activity for the discovery of new antimalarial drug candidates.
Weighted centroid trees: a general approach to summarize phylogenies in single-labeled tumor mutation tree inference
Authors: Vasei Hamed , Foroughmand-Araabi Mohammad-Hadi , Daneshgar Amir 
Published: July 2024

Abstract

Motivation
Tumor trees, which depict the evolutionary process of cancer, provide a backbone for discovering recurring evolutionary processes in cancer. While they are not the primary information extracted from genomic data, they are valuable for this purpose. One such extraction method involves summarizing multiple trees into a single representative tree, such as consensus trees or supertrees.

Results
We define the “weighted centroid tree problem” to find the centroid tree of a set of single-labeled rooted trees through the following steps: (i) mapping the given trees into the Euclidean space, (ii) computing the weighted centroid matrix of the mapped trees, and (iii) finding the nearest mapped tree (NMTP) to the centroid matrix. We show that this setup encompasses previously studied parent–child and ancestor–descendent metrics as well as the GraPhyC and TuELiP consensus tree algorithms. Moreover, we show that, while the NMTP problem is polynomial-time solvable for the adjacency embedding, it is NP-hard for ancestry and distance mappings. We introduce integer linear programs for NMTP in different setups where we also provide a new algorithm for the case of ancestry embedding called 2-AncL2, that uses a novel weighting scheme for ancestry signals. Our experimental results show that 2-AncL2 has a superior performance compared to available consensus tree algorithms. We also illustrate our setup’s application on providing representative trees for a large real breast cancer dataset, deducing that the cluster centroid trees summarize reliable evolutionary information about the original dataset.

Availability and implementation
https://github.com/vasei/WAncILP.
More power by using fewer permutations
Authors: Koning Nick W 
Published: July 2024

Abstract
It is conventionally believed that permutation-based testing methods should ideally use all permutations. We challenge this by showing that we can sometimes obtain dramatically more power by using a tiny subgroup. As the subgroup is tiny, this also comes at a much lower computational cost. Moreover, the method remains valid for the same hypotheses. We exploit this to improve the popular permutation-based Westfall and Young MaxT multiple testing method. We analyse the relative efficiency in a Gaussian location model, and find the largest gain in high dimensions.
Synthesis, solid-state structures, and properties of linear and tripodal flexible molecules with pyrazinopyrazine moieties
Authors: Ohmura Yuto , Oketani Ryusei , Konishi Akihito , Yasuda Makoto , Hisaki Ichiro 
Published: July 2024

Abstract
Pyrazino[2,3-b]pyrazine, which is a naphthalene analog with iminium nitrogen atoms at 1,4,5,8-positions instead of sp2-carbon atoms, is attractive as a building block for nitrogen highly contained π-conjugated systems. In this study, we synthesized pyrazino[2,3-b]pyrazine-based linear and tripodal molecules, in which pyrazino[2,3-b]pyrazine moieties are bonded with the central benzene ring at 1,4-positions and 1,3,5-positions, respectively, giving conformationally flexible and moderately π-conjugated molecules. It is noteworthy that the tripodal one forms unique interdigitated dimer with a small cavity in a crystalline state because of flexible tripodal molecular shape.
Factors Associated With Unfavorable Treatment Outcomes Among Persons With Pulmonary Tuberculosis: A Multicentric Prospective Cohort Study From India
Authors: Prakash Babu Senbagavalli , Ezhumalai Komala , Raghupathy Kalaivani , Karoly Meagan , Chinnakali Palanivel , Gupte Nikhil , Paradkar Mandar , Devarajan Arutselvi , Dhanasekaran Mythili , Thiruvengadam Kannan , Dauphinais Madolyn Rose , Gupte Akshay N , Shivakumar Shrivijay Balayogendra , Thangakunam Balamugesh , Christopher Devasahayam Jesudas , Viswanathan Vijay , Mave Vidya , Gaikwad Sanjay , Kinikar Aarti , Kornfeld Hardy , Horsburgh C Robert , Chandrasekaran Padmapriyadarsini , Hochberg Natasha S , Salgame Padmini , Gupta Amita , Roy Gautam , Ellner Jerrold , Sinha Pranay , Sarkar Sonali 
Published: July 2024

Abstract
In this prospective cohort of 2006 individuals with drug-susceptible tuberculosis in India, 18% had unfavorable treatment outcomes (4.7% treatment failure, 2.5% recurrent infection, 4.1% death, 6.8% loss to follow-up) over a median 12-month follow-up period. Age, male sex, low education, nutritional status, and alcohol use were predictors of unfavorable outcomes.
Amsterdam’s circular economy at a world-ecological crossroads: postcapitalist degrowth or the next regime of capital accumulation?
Authors: Thompson Matthew , Cator Charlotte , Beel David , Jones Ian Rees , Jones Martin , Morgan Kevin 
Published: July 2024

Abstract
This article conceptualises the circular economy as a space of immaterial, as well as material, metabolic flows mediated by capitalism and planetary urbanisation. World-ecology provides us with the critical lens to view the circular economy as part of an emergent regime of accumulation that may supersede neoliberalism. However, if each regime entails new frontier zones for appropriating cheap natures and dumping wastes, then the circular economy—as a strategy for revalorising waste—presents a possible structural limit to capitalism’s further expansion. Moreover, when combined with notions of degrowth and doughnut economics, the circular economy may provide an imaginary and set of prefigurative practices that point towards a postcapitalist economy. Through a case study of Amsterdam—a city aiming to be fully circular by 2050—we examine this contradictory crossroads, problematising the idea of circularity within capitalism and exploring the potential of postcapitalist alternatives within the circular economy.
Clinical impact of novel cardiovascular magnetic resonance technology on patients with congenital heart disease: a scientific statement of the Association for European Pediatric and Congenital Cardiology and the European Association of Cardiovascular Imaging of the European Society of Cardiology
Authors: Voges Inga , Raimondi Francesca , McMahon Colin J , Ait-Ali Lamia , Babu-Narayan Sonya V , Botnar René M , Burkhardt Barbara , Gabbert Dominik D , Grosse-Wortmann Lars , Hasan Hosan , Hansmann Georg , Helbing Willem A , Krupickova Sylvia , Latus Heiner , Martini Nicola , Martins Duarte , Muthurangu Vivek , Ojala Tiina , van Ooij Pim , Pushparajah Kuberan , Rodriguez-Palomares Jose , Sarikouch Samir , Grotenhuis Heynric B , Greil F Gerald , Bohbot Yohann , Cikes Maja , Dweck Marc , Donal Erwan , Grapsa Julia , Keenan Niall , Petrescu Aniela Monica , Szabo Liliana , Ricci Fabrizio , Uusitalo Valtteri 
Published: July 2024

Abstract
Cardiovascular magnetic resonance (CMR) imaging is recommended in patients with congenital heart disease (CHD) in clinical practice guidelines as the imaging standard for a large variety of diseases. As CMR is evolving, novel techniques are becoming available. Some of them are already used clinically, whereas others still need further evaluation. In this statement, the authors give an overview of relevant new CMR techniques for the assessment of CHD. Studies with reference values for these new techniques are listed in the Supplementary data online, supplement.
Full circumferential human tracheal replacement: a systematic review
Authors: Thierry Briac , Arakelian Lousineh , Denoyelle Françoise , Larghero Jérôme , Wurtz Alain 
Published: July 2024

Summary
Full Circumferential Tracheal Replacement (FCTR) is a surgical challenge, indicated in rare cases of extensive tracheal resection, with no consensus on surgical technique or materials. A systematic review according to PRISMA guidelines was carried out from 2000 to 2022 to identify cases of FCTR, to compare surgical indications, the nature of the tracheal substitutes and their immunological characteristics, surgical replacement techniques and vascularization. Thirty-seven patients, including five children, underwent FCTR surgery using 4 different techniques: thyrotracheal complex allograft (n = 2), aorta (n = 12), autologous surgical reconstruction (n = 19), tissue-engineered decellularized trachea (n = 4). The mean follow-up was 4 years. Of the 15 deceased patients, 10 died of the progression of the initial pathology. For the majority of the teams, particular care was given to the vascularization of the substitute, in order to guarantee long-term biointegration. This included either direct vascularization via vascular anastomosis, or an indirect technique involving envelopment of the avascular substitute in a richly vascularized tissue. Stent placement was standard, except for autologous surgical reconstructions where tracheal caliber was stable. Internal stents were frequently complicated by granulation and stenosis. Although epithelial coverage is essential to limit endoluminal proliferation and act as a barrier, fully functional ciliated airway epithelium did not seem to be necessary. In order to facilitate future comparisons, a standardized clinical trial, respecting regulatory constraints, including routine follow-up with tracheal biomechanics assessment and scheduled biopsies could be proposed. It would help collecting information such as dynamics and mechanisms of tracheal bio-integration and regeneration.
Mck1-mediated proteolysis of CENP-A prevents mislocalization of CENP-A for chromosomal stability in Saccharomyces cerevisiae
Authors: Zhang Tianyi , Au Wei-Chun , Ohkuni Kentaro , Shrestha Roshan L , Kaiser Peter , Basrai Munira A 
Published: July 2024

Abstract
Centromeric localization of evolutionarily conserved CENP-A (Cse4 in Saccharomyces cerevisiae) is essential for chromosomal stability. Mislocalization of overexpressed CENP-A to noncentromeric regions contributes to chromosomal instability in yeasts, flies, and humans. Overexpression and mislocalization of CENP-A observed in many cancers are associated with poor prognosis. Previous studies have shown that F-box proteins, Cdc4 and Met30 of the Skp, Cullin, F-box ubiquitin ligase cooperatively regulate proteolysis of Cse4 to prevent Cse4 mislocalization and chromosomal instability under normal physiological conditions. Mck1-mediated phosphorylation of Skp, Cullin, F-box-Cdc4 substrates such as Cdc6 and Rcn1 enhances the interaction of the substrates with Cdc4. Here, we report that Mck1 interacts with Cse4, and Mck1-mediated proteolysis of Cse4 prevents Cse4 mislocalization for chromosomal stability. Our results showed that mck1Δ strain overexpressing CSE4 (GAL-CSE4) exhibits lethality, defects in ubiquitin-mediated proteolysis of Cse4, mislocalization of Cse4, and reduced Cse4–Cdc4 interaction. Strain expressing GAL-cse4-3A with mutations in three potential Mck1 phosphorylation consensus sites (S10, S16, and T166) also exhibits growth defects, increased stability with mislocalization of Cse4-3A, chromosomal instability, and reduced interaction with Cdc4. Constitutive expression of histone H3 (Δ16H3) suppresses the chromosomal instability phenotype of GAL-cse4-3A strain, suggesting that the chromosomal instability phenotype is linked to Cse4-3A mislocalization. We conclude that Mck1 and its three potential phosphorylation sites on Cse4 promote Cse4–Cdc4 interaction and this contributes to ubiquitin-mediated proteolysis of Cse4 preventing its mislocalization and chromosomal instability. These studies advance our understanding of pathways that regulate cellular levels of CENP-A to prevent mislocalization of CENP-A in human cancers.
On the nature of influence: identifying and characterizing superdiffusers in seven countries
Authors: Cruz Shannon M , Manata Brian , High Andrew C , Worley Timothy R 
Published: July 2024

Abstract
An important component of theoretical and applied work on social influence is identifying influential people. Boster et al.’s theoretical framework on superdiffusers provides one method of doing so, but important questions on the nature of influence remain. In particular, because existing studies have primarily sampled U.S. college students, it remains unclear whether (a) the framework adequately characterizes superdiffusers in different populations and (b) our current understanding of superdiffusers applies outside of the United States. To address these questions, we used an online survey to examine factorial validity, metric invariance, and correlates of superdiffuser characteristics in the United States, the United Kingdom, Singapore, South Africa, India, Pakistan, and Australia (total N = 3,476). Results suggest the superdiffuser framework can fruitfully be used to describe and identify influential individuals in diverse contexts. Influence also appears to be a relatively trait-like individual difference rather than a matter of unique fit to a particular country or culture.