bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evolution of antimicrobial stewardship in pneumonia management: A comprehensive bibliometric analysis
Authors: Zhexenova Azhar N. , Mukyshova Gulbanu , Aliyeva Lida , Kandygulova Gulnara , Yegizbayeva Dina , Zhylkybekova Aliya , Ablakimova Nurgul 
Published: July 2024

AbstractObjectivesThis comprehensive bibliometric analysis explores the evolving trends in antimicrobial stewardship programs for enhancing treatment and diagnostics of pneumonia from 2006 to 2023.Materials and methodsThis research included a performance analysis and science mapping using RStudio v.4.3.1 and the bibliometric R‐package, with a data analysis conducted using Biblioshiny and Scopus. The study identified publication trends, prolific journals, leading institutions and authors, collaboration patterns, and keyword frequencies.ResultsThe study, based on 789 relevant studies from 287 sources, reveals a substantial increase in publications, collaborative authorship, and citations, with an average of 14.37 citations per document. The Annual Growth Rate for this research domain exhibits a steady increase of 30.13%, emphasizing the expanding scope of research output. Twelve key journals are identified using Bradford's Law with “Antibiotics” being the most prolific, contributing 6.5% of the total articles during the study period. Leading institutions in this research domain include the All‐India Institute of Medical Sciences and the University of Cape Town, each with 21 articles, reflecting their commitment. Dr. S.E. Cosgrove emerges as a key author with eight contributions, followed by other influential contributors. The United States leads in the number of publications, with Italy and Spain following closely. The analysis reveals a concentration of research output in high‐income countries, raising questions about accessibility and research capabilities in lower‐income nations. Addressing these disparities is crucial for comprehensive global strategies in pneumonia management. The study acknowledges limitations, such as database selection and language bias.ConclusionThe research trends in antimicrobial stewardship for pneumonia treatment and diagnostics demonstrate a global increase in scholarly output. These findings provide valuable insights into collaborative networks, influential authors, leading institutions, and emerging topics.
Predicting latent counselor interpersonal stress profiles according to challenging clients
Authors: Moore C. Missy , Crawford Carey C. , Graham Adrienne R. , Burrell Vivian D. 
Published: July 2024

AbstractClinical work with challenging, difficult, or dislikable clients can elicit negative experiences for professional counselors. Using quantitative content analysis methodology embedded in a cross‐sectional, correlational design, we examined the prevalence of challenging client presentations and their influence on latent counselor interpersonal stress profiles using a large sample (n = 1356). Challenging client presentations associated with client expectations and progress, therapy‐interfering behaviors, client traits and behaviors, and counselor concerns and experiences predicted counselor membership in Disconnected, Exasperated, Paralyzed, Anguished, and Distressed Counselor profiles in comparison to the Relaxed Counselor profile. Recommendations for strengthening clinical practice and counselor wellness when working with challenging, difficult, or dislikable clients are provided.
Sarcopenia is associated with short‐ and long‐term mortality in patients with acute‐on‐chronic liver failure
Authors: Zeng Fan , Jiang Wei , Chang Xiujun , Yang Fuxun , Luo Xiaoxiu , Liu Rongan , Lei Yu , Li Jiajia , Pan Chun , Huang Xiaobo , Sun Huaiqiang , Lan Yunping 
Published: July 2024

AbstractBackgroundWhile sarcopenia is recognized as a predictor of mortality in cirrhosis, its influence on acute‐on‐chronic liver failure (ACLF) remains uncertain. Despite multiple studies examining the impact of sarcopenia on short‐term mortality in patients with ACLF, the sample size of these studies was limited, and their outcomes were inconsistent. Therefore, this study aimed to explore the impact of sarcopenia on both short‐ and long‐term mortality in patients with ACLF.MethodsThis retrospective cohort study included 414 patients with ACLF that were treated between January 2016 and September 2022. Sarcopenia was diagnosed based on the measurement of the skeletal muscle index at the third lumbar vertebra (L3‐SMI). Subsequently, the patients were divided into sarcopenia and non‐sarcopenia groups. We analysed the basic clinical data of the two groups. Multivariate Cox proportional analysis was used to analyse short‐term (28 days) and long‐term (1 year and overall) mortality rates.ResultsA total of 414 patients were included, with a mean age of 52.88 ± 13.41 years. Among them, 318 (76.8%) were male, and 239 (57.7%) had sarcopenia. A total of 280 (67.6%) patients died during the study period. Among them, 153 patients died within 28 days (37%) and 209 patients died within 1 year (50.5%). We found that the 28‐day, 1‐year and overall mortality rates in the sarcopenia group were significantly higher than those in the non‐sarcopenia group (37% vs. 22.3%, P < 0.01; 50.5% vs. 34.9%, P < 0.01; and 67.6% vs. 53.1%, P < 0.01, respectively). Multivariate Cox regression analysis revealed that sarcopenia was significantly associated with increased mortality. The hazard ratios for sarcopenia were 2.05 (95% confidence interval [CI] 1.41–3.00, P < 0.01) for 28‐day mortality, 1.81 (95% CI 1.29–2.54, P < 0.01) for 1‐year mortality and 1.82 (95% CI 1.30–2.55, P < 0.01) for overall mortality. In addition, muscle density and international normalized ratio were associated with short‐ and long‐term mortality.ConclusionsSarcopenia is associated with both short‐ and long‐term mortality in patients with ACLF. Therefore, regular monitoring for sarcopenia is important for these patients.
Targeted nutritional intervention attenuates experimental lung cancer cachexia
Authors: van de Worp Wouter R. P. H. , Theys Jan , Wolfs Cecile J. A. , Verhaegen Frank , Schols Annemie M. W. J. , van Helvoort Ardy , Langen Ramon C. J. 
Published: July 2024

AbstractBackgroundCachexia, a syndrome with high prevalence in non‐small cell lung cancer patients, impairs quality of life and reduces tolerance and responsiveness to cancer therapy resulting in decreased survival. Optimal nutritional care is pivotal in the treatment of cachexia and a recommended cornerstone of multimodal therapy. Here, we investigated the therapeutic effect of an intervention diet consisting of a specific combination of high protein, leucine, fish oil, vitamin D, galacto‐oligosaccharides, and fructo‐oligosaccharides on the development and progression of cachexia in an orthotopic lung cancer mouse model.MethodsEleven‐week‐old male 129S2/Sv mice were orthotopically implanted with 344P lung epithelial tumour cells or vehicle (control). Seven days post‐implantation tumour‐bearing (TB) mice were allocated to either intervention‐ or isocaloric control diet. Cachexia was defined as 5 days of consecutive body weight loss, after which mice were euthanized for tissue analyses.ResultsTB mice developed cachexia accompanied by significant loss of skeletal muscle mass and epididymal fat mass compared with sham operated mice. The cachectic endpoint was significantly delayed (46.0 ± 15.2 vs. 34.7 ± 11.4 days), and the amount (−1.57 ± 0.62 vs. −2.13 ± 0.57 g) and progression (−0.26 ± 0.14 vs. −0.39 ± 0.11 g/day) of body weight loss were significantly reduced by the intervention compared with control diet. Moreover, systemic inflammation (pentraxin‐2 plasma levels) and alterations in molecular markers for proteolysis and protein synthesis, indicative of muscle atrophy signalling in TB‐mice, were suppressed in skeletal muscle by the intervention diet.ConclusionsTogether, these data demonstrate the potential of this multinutrient intervention, targeting multiple components of cachexia, as integral part of lung cancer management.
Exploration of gut microbial diversity of pheasants through pyrosequencing of 16S rRNA gene
Authors: Bukhari Syed M. , Andleeb Shahla , Alghamdi Huda A. , Rehman Khalil ur , Javid Arshad , Ali Waqas , Abbas Yassar , Nokhaiz Kashaf 
Published: July 2024

AbstractDespite the diversity of microbiota in birds is similar to that of other animals, there is a lack of research on the gut microbial diversity of nondomesticated bird species. This study aims to address this gap in knowledge by analyzing the bacterial communities present in the gut of two important game bird species, the Ring‐necked pheasant (Phasianus colchicus) and the Green pheasant (Phasianus versicolor) to understand the gut microbial diversity of these species. The gut microbiome of 10 individual pheasants from two different species was studied using pooled fecal samples. We used 16S rRNA gene sequencing on the Ion S5 XL System next‐generation sequencing with Mothur and SILVA Database for taxonomic division. An average of 141 different operational taxonomic units were detected in the gut microbiome. Analysis of microbial classification revealed the presence of 191 genera belonging to 12 different phyla in both pheasants. Alpha diversity indices revealed that P. colchicus exhibited most prevalence firmicutes with bacillus species microbial community than P. versicolor. Alpha diversity indices indicated that P. colchicus had a more diverse community and P. versicolor had a greater diversity of evolutionary lineages, while both species had similar levels of species richness and sample inclusiveness. These findings may have implications for the health and well‐being of pheasants, serving as a reference for their bacterial diversity. Additionally, they provide a baseline for future research and conservation efforts aimed at improving the health and well‐being of these and possibly other avian species.
Fostering citizen‐engaged HIV implementation science
Authors: Tan Benedict Xin Hao , Chong Shao Yuan , Ho Daniel Weng Siong , Wee Ye Xuan , Jamal Muhammad Hafiz , Tan Rayner Kay Jin 
Published: July 2024

AbstractIntroductionSuccessful implementation of evidence‐based practices depends on contextual factors like stakeholder engagement, the socio‐political environment, resource availability, and stakeholders’ felt needs and preferences. Nevertheless, inequities in implementation exist and undermine efforts to address HIV in marginalized key populations. Implementation science shows promise in addressing such inequities in the HIV response, but can be limited without meaningful engagement from citizens or communities.DiscussionWe define the concept of a citizen‐engaged HIV implementation science as one that involves citizens and communities deeply in HIV implementation science activities. In this commentary, we discuss how citizen science approaches can be leveraged to spur equity in HIV implementation science. Drawing on three areas previously defined by Geng and colleagues that serve to drive impactful implementation science in the HIV response, we discuss how citizens can be engaged when considering “whose perspectives?”, “what questions are being asked?” and “how are questions asked?”. With respect to “whose perspectives?” a citizen‐engaged HIV implementation science would leverage participatory methods and tools, such as co‐creation, co‐production and crowdsourcing approaches, to engage the public in identifying challenges, solve health problems and implement solutions. In terms of “what questions are being asked?”, we discuss how efforts are being made to synthesize citizen or community‐led approaches with existing implementation science frameworks and approaches. This also means that we ensure communities have a say in interrogating and deconstructing such frameworks and adapting them to local contexts through participatory approaches. Finally, when considering “how are questions asked?”, we argue for the development and adoption of broad, guiding principles and frameworks that account for dynamic contexts to promote citizen‐engaged research in HIV implementation science. This also means avoiding narrow definitions that limit the creativity, innovation and ground‐up wisdom of local citizens.ConclusionsBy involving communities and citizens in the development and growth of HIV implementation science, we can ensure that our implementation approaches remain equitable and committed to bridging divides and ending AIDS as a public health threat. Ultimately, efforts should be made to foster a citizen‐ and community‐engaged HIV implementation science to spur equity in our global HIV response.
Decorin and/or biglycan knockdown in aged mouse patellar tendon impacts fibril morphology, scar area, and mechanical properties
Authors: Newton Joseph B. , Weiss Stephanie N. , Nuss Courtney A. , Darrieutort‐Laffite Christelle , Eekhoff Jeremy D. , Birk David E. , Soslowsky Louis J. 
Published: July 2024

AbstractSmall leucine‐rich proteoglycans, such as decorin and biglycan, play pivotal roles in collagen fibrillogenesis during development, healing, and aging in tendon. Previous work has shown that the absence of decorin and biglycan affects fibril shape and mechanical properties during tendon healing. However, the roles of decorin and biglycan in the healing process of aged tendons are unclear. Therefore the objective of this study was to evaluate the differential roles of decorin and biglycan during healing of patellar tendon injury in aged mice. Aged (300 days old) female Dcn+/+/Bgn+/+ control (WT, n = 52), Dcnflox/flox (I‐Dcn−/−, n = 36), Bgnflox/flox (I‐Bgn−/−, n = 36), and compound Dcnflox/flox/Bgnflox/flox (I‐Dcn−/−/Bgn−/−, n = 36) mice with a tamoxifen‐inducible Cre were utilized. Targeted gene expression, collagen fibril diameter distributions, mechanical properties, and histological assays were employed to assess the effects of knockdown of decorin and/or biglycan at the time of injury. Knockdown resulted in alterations in fibril diameter distribution and scar area, but surprisingly did not lead to many differences in mechanical properties. Biglycan played a larger role in early healing stages, while decorin is more significant in later stages, particularly in scar remodeling. This study highlights some of the differential roles of biglycan and decorin in the regulation of fibril structure and scar area, as well as influencing gene expression during healing in aged mice.
Prevalence and significance of autoantibodies in children with metabolic dysfunction‐associated steatotic liver disease: A systematic review and meta‐analysis
Authors: Bolia Rishi , Goel Akhil , Semwal Pooja , Srivastava Anshu 
Published: July 2024

AbstractSignificance of autoantibodies in pediatric metabolic dysfunction‐associated steatotic liver disease (MASLD) is unknown. Our aim was to determine the prevalence and significance of autoantibodies in MASLD. PubMed and Scopus were searched and six articles (689 [487 males] MASLD patients) were identified. Antinuclear antibodies (ANA) was positive in 28% (95% confidence interval [CI]: 17%–39%, n = 6 studies), antismooth muscle antibodies (ASMA) in 28% (95% CI: 8%–50%, n = 5 studies), actin‐positive in 15% (95% CI: 10%–20%, n = 2 studies) and elevated immunoglobulin G in 17% (95% CI: 1%–39%, n = 4 studies). Anti‐liver‐kidney‐microsomal antibody was not present in any patient. There was no significant association of ANA positivity with degree of liver steatosis, liver fibrosis or nonalcoholic fatty liver disease activity score (NAS) but patients with ASMA positivity had advanced fibrosis (pooled risk ratio [RR] 1.77; 95% CI 1.16–2.71) and higher risk of NAS ≥5 (pooled RR 1.21; 95% CI: 1.01–1.44, n = 2 studies, 243 patients). To conclude, non‐organ specific autoantibodies are present in over one‐fourth of children with MASLD and the presence of ASMA maybe associated with increased disease severity.
Deciphering the interactions between altertoxins and glutenin based on molecular dynamic simulation: inspiration from detection
Authors: Yuan Shaofeng , Chen Yulun , Wen Aying , Liu Qingrun , He Yingying , Yu Hang , Guo Yahui , Cheng Yuliang , Qian He , Xie Yunfei , Yao Weirong 
Published: July 2024

AbstractBACKGROUNDMycotoxin contamination of food has been gaining increasing attention. Hidden mycotoxins that interact with biological macromolecules in food could make the detection of mycotoxins less accurate, potentially leading to the underestimation of the total exposure risk. Interactions of the mycotoxins alternariol (AOH) and alternariol monomethyl ether (AME) with high‐molecular glutenin were explored in this study.RESULTSThe recovery rates of AOH and AME (1, 2, and 10 μg kg−1) in three types of grains (rice, corn, and wheat) were relatively low. Molecular dynamics (MD) simulations indicated that AOH and AME bound to glutenin spontaneously. Hydrogen bonds and π‐π stacking were the primary interaction forces at the binding sites. Alternariol with one additional hydroxyl group exhibited stronger binding affinity to glutenin than AME when analyzing average local ionization energy. The average interaction energy between AOH and glutenin was −80.68 KJ mol−1, whereas that of AME was −67.11 KJ mol−1.CONCLUSIONThis study revealed the mechanisms of the interactions between AOH (or AME) and high‐molecular glutenin using MD and molecular docking. This could be useful in the development of effective methods to detect pollution levels. These results could also play an important role in the evaluation of the toxicological properties of bound altertoxins. © 2024 Society of Chemical Industry.
Anterior cruciate ligament primary repair revision rates are increased in skeletally mature patients under the age of 21 compared to reconstruction, while adults (>21 years) show no significant difference: A systematic review and meta‐analysis
Authors: Rilk Sebastian , Goodhart Gabriel C. , van der List Jelle P. , Von Rehlingen‐Prinz Fidelius , Vermeijden Harmen D. , O'Brien Robert , DiFelice Gregory S. 
Published: July 2024

AbstractPurposeTo evaluate the impact of age as a risk factor on the revision rates of anterior cruciate ligament (ACL) primary repair (ACLPR), dynamic intraligamentary stabilization (DIS) and bridge‐enhanced ACL restoration (BEAR) compared to ACL reconstruction (ACLR).MethodsA systematic literature search was performed for comparative studies comparing outcomes for ACLPR, DIS or BEAR to ACLR. A random‐effects meta‐analysis was performed to assess nondifferentiated and age‐differentiated (skeletally mature patients ≤21 and >21 years) ACL revision and reoperation risk, as well as results for subjective outcomes. Methodological study quality was assessed using the Risk of Bias Tool 2.0c and Methodological Index for Nonrandomized Studies tools.ResultsA total of 12 studies (n = 1277) were included. ACLR demonstrated a lower nonage‐stratified revision risk at 2 years versus ACLPR, DIS and BEAR, but a similar revision risk at 5 years when compared to DIS. However, an age‐stratified analysis demonstrated a significantly increased ACLPR revision risk as compared to ACLR in skeletally mature patients ≤21 years of age (risk ratios [RR], 6.33; 95% confidence interval [CI], 1.18–33.87, p = 0.03), while adults (>21 years) showed no significant difference between groups (RR, 1.48; 95% CI, 0.25–8.91, n.s.). Furthermore, DIS reoperation rates were significantly higher than respective ACLR rates (RR, 2.22; 95% CI, 1.35–3.65, p = 0.002), whereas BEAR (RR, 1.07; 95% CI, 0.41–2.75, n.s.) and ACLPR (RR, 0.81; 95% CI, 0.21–3.09, n.s.) showed no differences. IKDC scores were equivalent for all techniques. However, ACLPR exhibited significantly better FJS (mean difference, 11.93; 95% CI, 6.36–17.51, p < 0.0001) and Knee injury and Osteoarthritis Outcome Score Symptoms (mean difference, 3.01; 95% CI, 0.42–5.60, p = 0.02), along with a lower Tegner activity reduction.ConclusionsACLPR in skeletally mature patients ≤21 years of age is associated with up to a six‐fold risk increase for ACL revision surgery compared to ACLR; however, adults (>21 years) present no significant difference. Based on the current data, age emerges as a crucial risk factor and should be considered when deciding on the appropriate treatment option in proximal ACL tears.Level of EvidenceLevel III.
Sulcus‐deepening trochleoplasty grants satisfactory results with minimal patellofemoral arthritis at 23–30 years of follow‐up
Authors: Dejour David , Guarino Amedeo , Pineda Tomas ,   ReSurg, Demey Guillaume 
Published: July 2024

AbstractPurposeThe purpose of this study was to evaluate the radiographic and clinical outcomes of sulcus‐deepening trochleoplasty at a minimum follow‐up of 23 years.MethodsThe authors evaluated a retrospective series of 10 patients (11 knees) who underwent trochleoplasty between 1993 and 2000. All patients were assessed at a minimum follow‐up of 23 years by an independent clinician who noted any patellar redislocations and collected the International Knee Documentation Committee (IKDC), Kujala scores and range of motion. Radiographic examination was performed to assess patellofemoral arthritis using the Iwano classification.ResultsA total of 11 knees, from five women and five men aged 25.6 ± 6.9 years (range, 15–47 years) underwent trochleoplasty during the inclusion period. All 11 knees underwent adjuvant procedures during trochleoplasty (100%): 10 had tibial tuberosity osteotomy (TTO) and vastus medialis plasty and 1 had only vastus medialis plasty (had prior TTO). At a follow‐up of 24.4 ± 2.1 years (range, 23–30 years), two patients were lost to follow‐up (18%). The Iwano classification was Grade 1 in three patients (33%), Grade 2 in four patients (44%) and Grade 4 in two patients (22%). The flexion range was 130 ± 8.7° and satisfaction was 9.2 ± 0.7, Kujala was 76.9 ± 8.5 and IKDC was 65.5 ± 13.8.ConclusionAt 23–30 years following sulcus‐deepening trochleoplasty in this small series of 10 patients (11 knees), patients had satisfactory clinical scores, only 1 patient reported an episode of traumatic patellar dislocation, and two knees had patellofemoral arthritis of Iwano Grade >2 (22%).Level of EvidenceLevel IV.
Evaluation of Seed Yield Stability of Lentil Genotypes by Linear Mixed‐Effects Models and Multitrait Stability Index
Authors: Shobeiri Seyedeh Soudabeh , Pezeshkpour Payam , Naseri Bita 
Published: July 2024

ABSTRACTTo evaluate performance stability for 13 lentil genotypes, experiments were performed at three locations, Ardebil, Zanjan, and Maragheh, during three growing seasons (2011–2013). Environment, genotype, and interaction of genotype × environment were significantly effective on 100‐seed weight, plant height, number of days to flowering, number of days to maturity, rate of seed filling, and single seed weight. Nominal grain yield biplot identified stability of 2, 12, 1, 3, and 6 genotypes with regard to grain yield. According to biplot analysis, Genotypes 1, 3, and 10 not only produced the highest grain yield but also showed the greatest stability in yield production. Genotypes 1, 6, 7, and 13 were identified as highly stable and productive based on grain yield, mean weight stability index, and weighted average of absolute scores of best linear unbiased predictions (WAASB). Genotypes 1 and 7 were best genotypes according to multitrait stability index (MTSI). Harmonic mean of the relative performance of genotypic predicted value (HMRPGV) recognized Genotypes 6, 1, 5, and 3 as highly stable, productive, and adaptable genotypes. In general, Genotype 1 indicated highest grain yield and desirable agronomic traits compared to other genotypes tested, suggesting this genotype as new cultivar.