bluuebunny/crossref_metadata_2025_split huggingface dataset:
Analysis of the influence of line type on the aerodynamic characteristics of high-speed trains in strong wind and sand environments
Authors: FU FU CAI-hui , DU DU Li-ming 
Published: August 2024

Abstract

Strong wind and sand environments are critical factors affecting high-speed trains' operation. In this paper, the -vortex analysis technique is employed to comparatively analyze the pressure and velocity distribution characteristics of the train surface when the train traveling at a speed of 250km per hour traverses a flat line, a 5m high embankment, and a 3m deep graben in a strong wind and sand environment. Additionally, the study examines the wake turbulence intensity and vortex structural characteristics of the tail car, and the aerodynamic power distribution and sand erosion situation. The results indicate that the change in line type significantly affects the sand flow characteristics around the train, which in turn affects the surface pressure field of the train. When running on the embankment and rift valley lines, more airflow vortices are generated on the leeward side of the train. The foot of the slope also produces a broken vortex structure with high vorticity and strong vortices, which significantly impacts the flow field around the train. In the flat line, the train is subjected to relatively uniform wind and sand impact, but the aerodynamic fluctuations are small; road riffle and embankment, especially on the embankment of the airflow complexity and variability, the flow field structure is the most complex, the aerodynamic characteristics of the train show prominent non-stationary characteristics, the train leeward side of the negative pressure area is also the largest, the transverse force is 45% larger than that in the flat line. In contrast, in the train in the riffle line operation, the headway resistance is significantly reduced. The tail vehicle resistance is the largest, and the drag force suffered is increased, 2.83 times and 0.2 times larger than that on the embankment and flat straight line, respectively.
Exploration of the Mechanism of Fritillaria Taibaiensis in stopping cough, eliminating phlegm and relieving asthma Based on Network Pharmacology,Molecular Simulation and animal experiments
Authors: Zhang Jian-hai , Mao Yong-po , Hu Shu-yun , Wu Ai-yun , Shi Jia , Feng Bin-bin 
Published: August 2024

Abstract

Background
Using network pharmacology and molecular docking methods, this study explores the mechanism of action of Fritillaria Taibaiensis (Taibai Beimu, TB) in relieving cough, asthma, and phlegm, and preliminarily verifies the relevant pathways through animal experiments.
Methods
Using traditional Chinese medicine database to screen the main components and targets, and obtaining disease targets through disease database, and repeated targets were summarized and deleted before being imported into Cytoscape software to construct a network; Using database to analyze protein-protein interactions of intersecting targets and obtain core targets. Perform enrichment analysis on intersecting targets and construct a "drug component target pathway disease" network; Simultaneously, Maestro software was used for molecular docking to verify the binding ability of the active ingredient to the core target. Animal experiments were conducted to analyze and verify the cough stopping, asthma relieving, and expectorant effects of TB; Western blot verification of its effect on the expression level of target proteins.
Results
9 active ingredients and 152 targets were screened, and KEGG pathway enrichment predicted that drugs mainly exert their effects through signaling pathways such as NF-κB, HIF1, and FoxO. Molecular docking showed that 93.3% of the binding activity was less than − 5kcal/mol, indicating good docking affinity. The low-dose of TB significantly reduced the number of coughs in mice within 3 minutes, while the high-dose group showed a significant extension in the latent period of wheezing. The excretion of phenol red in the trachea was significantly increased in the high-dose group. Compared with the normal group, the protein expression levels of TLR4, NF-κB, and MyD88 in the model group were significantly increased (P < 0.001, P < 0.01); compared with the model group, the protein expression levels of TLR4, NF-κB, and MyD88 in the high-dose TB group were significantly decreased (P < 0.01, P < 0.05); compared with the pentosidine group, there were no significant differences among the treatment groups.
Conclusions
Through experimental verification and network pharmacology analysis, it can be found that TB inhibits the inflammatory response in mice, and its mechanism of action may be related to the inhibition of TLR4/NF-κB signaling pathway activation.
Ground Testing and Calibration of Focal Plane Detector Flight Model on Board the First Pathfinder of CATCH
Authors: Li Panping , Wen Xiangyang , Li Zhengwei , Gao Min , Yin Qian-Qing , Tao Lian , Zhao Kang , Zhao Qingchang , Wang Yusa , Zhao Zijian , Meng Bin , Zhao Shujie , Huang Yiming , Xiao Jingyu , Zhang Yifan , Yang Sheng , Chen Wen , Zhou Heng , Yang Yong , He Huilin , Ma Ruican , Yang Shuai , Huang Guoli , Li YaJun , Cao Jiewei , Hou Shu-Jin , Liu Xiaojing , Wang Jinzhou , Sun Liang , Zhang Shuang-Nan , Xiong Shaolin , Ma Xiang , Huang Yue , Song Liming 
Published: August 2024

Abstract

CATCH -1, as the first satellite of Chasing All Transients Constellation Hunters (CATCH ) space mission, was successfully launched into its expected orbit on June 22, 2024. The flight model underwent environmental tests before launch, including thermal cycling, thermal vacuum, and mechanical evaluations. The CATCH -1 detector system is equipped with a 4-pixel Silicon Drift Detector (SDD) array. To ensure the reliability and redundancy of the CATCH -1 detector system, two sets of data acquisition systems were independently designed and cal-ibrated. Our focus is on presenting the ground calibration results of CATCH -1, which demonstrate a strong linear correlation between energy and channel. The main data acquisition system achieves an energy resolution of ∼ 120 eV@4 keV, while the backup data acquisition system has a slightly lower energy resolution of around 150 eV@4 keV, both meeting the design requirement of ≤ 160 eV@4 keV. Additionally, the time resolution is 4 µs, complying with the design requirement of ≤ 10 µs. The calibration database now includes the ground calibration results of CATCH -1, establishing a dependable basis for future data analysis. The development experience, calibration, and test results of this detector system will also provide a solid foundation for subsequent tasks such as CATCH -2.
Restoring Intricate Miao Embroidery Patterns: A GAN-Based U-Net with Spatial-Channel Attention
Authors: Zhong Cheng , Yu Xiaomin , Xia Huan , Xie Rongdong , Xu Qingyi 
Published: August 2024

Abstract

Traditional Miao embroidery features intricate pattern structures. The hand embroidery restoration techniques are extremely labor-intensive and time-consuming. In order to improve the efficiency of embroidery image restoration, this paper develops a framework for Miao embroidery pattern image restoration. The framework combines generative adversarial network with U-Net. The U-Net incorporates gated convolutions and spatial-channel attention mechanisms to enhance the model's ability to learn and reconstruct the intricate textures and structures of the embroidery. The proposed algorithm is compared with the current mainstream algorithms using PSNR, SSIM, and LPIPS metrics. The results show that this algorithm performs better than other methods in Miao embroidery restoration. The source code and datasets used in this study are available at Zenodo (DOI: 10.5281/zenodo.12759273).
Investigation of the Effect of Waterpik Use on the Surface Properties of Porcelain and Zirconium Materials
Authors: yanıkoğlu nuran , kaya nihan , topdağı başak , kürüm muhammet 
Published: August 2024

Abstract

Statement of Problem The surface properties of materials affect many parameters, including aesthetic, mechanical, and physical properties. Oral hygiene practices are among the factors that change surface properties over time.
Purpose. The purpose of this study is to investigate the effects of Waterpik usage at two different pressure levels on the surface roughness and surface hardness of two different materials frequently chosen in current prosthetic restorations.
Materials and Methods The study used two types of materials: monolithic zirconium and feldspathic porcelain with a metal cr-co substructure. The materials were shaped into rectangular prisms with dimensions of 10x10x2 mm. It was calculated using the G* power program that 10 samples from each material were needed for both 5 Psi and 10 Psi pressure values. The roughness (Ra) and hardness (Hv) values of the material surfaces were recorded after Waterpik applications. Kurtosis and skewness tests were conducted to examine the normal distribution of continuous variables. The ANOVA test was used to compare surface roughness and hardness values between groups when the normal distribution condition was met, and the Kruskal Wallis test was used when it was not. Post-hoc tests were performed using Levene's for independent groups and paired t-test for dependent groups after the ANOVA test. The level of statistical significance was set at P <0.05.
Results Both feldspathic porcelain and monolithic zirconium materials showed a significant increase in surface roughness values for both 5 Psi and 10 Psi pressure values (P<0.05). When surface hardness properties were examined, a significant decrease was observed in both feldspathic porcelain and monolithic zirconium samples at both 5 Psi and 10 Psi pressure values (P<0.05).
Conclusion Feldspathic porcelain and monolithic zirconium restorations produced under appropriate conditions do not have their clinical success affected by the change in surface properties observed when cleaned daily with a Waterpik under 5 Psi and 10 Psi pressure.
CLINICAL IMPLICATIONS The changes observed in the surface properties of feldspathic porcelain and monolithic zirconium restorations, which have been manufactured under appropriate conditions and cleaned daily with an oral irrigator at 5 Psi and 10 Psi pressure, do not affect the clinical success of the material.
Multivariate, Multi-omic Analysis in 799,429 Individuals Identifies 134 Loci Associated with Somatoform Traits
Authors: Davis Christal , Toikumo Sylvanus , Hatoum Alexander , Khan Yousef , Pham Benjamin , Pakala Shreya , Feuer Kyra , Gelernter Joel , Sanchez-Roige Sandra , Kember Rachel , Kranzler Henry 
Published: August 2024

Abstract

Somatoform traits, which manifest as persistent physical symptoms without a clear medical cause, are prevalent and pose challenges to clinical practice. Understanding the genetic basis of these disorders could improve diagnostic and therapeutic approaches. With publicly available summary statistics, we conducted a multivariate genome-wide association study (GWAS) and multi-omic analysis of four somatoform traits—fatigue, irritable bowel syndrome, pain intensity, and health satisfaction—in 799,429 individuals genetically similar to Europeans. GWAS identified 134 loci significantly associated with a somatoform common factor, including 44 loci not significant in the input GWAS and 8 novel loci for somatoform traits. Gene-property analyses highlighted enrichment of genes involved in synaptic transmission and enriched gene expression in 12 brain tissues. Six genes, including members of the CD300 family, had putatively causal effects mediated by protein abundance. There was substantial polygenic overlap (76–83%) between the somatoform and externalizing, internalizing, and general psychopathology factors. Somatoform polygenic scores were associated with obesity, Type 2 diabetes, tobacco use disorder, and mood/anxiety disorders in independent biobanks. Drug repurposing analyses suggested potential therapeutic targets, including MEK inhibitors. Mendelian randomization indicated protective effects of gut microbiota, includingRuminococcus bromii. These biological insights provide promising avenues for treatment development.
The effect of using some high-use and low-use elements on single cross KSC 703 corn variety as a second crop in Azarshahr, Iran
Authors: rahmatollahi Reza 
Published: August 2024

Abstract

Corn plant is of great importance for the sufficient and economical production of plant-based proteins both in the world and in Iran. Corn cultivation in Iran contributes greatly to the production of animal protein as well. In addition, starch, glucose and oil obtained from this plant are of great importance in terms of raw material in the country's economy. In order to investigate the effect of using some low-use and high-use elements on the yield of single cross KSC 703 corn variety, an experiment was carried out in the 2022 crop year in the form of randomized complete blocks in 11 levels and in 3 replications in Azar Shahr, Iran. The traits that were measured included the plant height, length of cob, diameter of cob, number of leaves, Leaf surface area، number of seeds in cob, number of row seeds in cob and number of florets in the tassel. The results of the analysis of variance showed that all the traits investigated in the experiment were under the influence of different fertilizer treatments were applied and they were significant at the level of statistical probability of 1%, which shows the effect of the treatments on the studied traits. According to the comparison of the average traits in all investigated traits, the use of nitrogen and phosphorus is 50% more in addition to micronutrient elements, iron, manganese, and copper, with phosphorus being 50% more in addition to all three elements, iron, manganese, and copper. In the evaluation of performance among different experimental treatments, it was found that the use of iron manganese sulfate treatment with nitrogen and phosphorus 50% more than the soil test has increased the yield by 82.60% compared to the control.
Mapping Parents’ Priorities and Needs in Supporting their Childrens’ Mental Health: A Situational Analysis and Needs Assessment in Czechia
Authors: Polášková Marie , Fišerová Marta , Kagström Anna 
Published: August 2024

Abstract

Childhood mental health disorders, particularly anxiety, present a significant global challenge, affecting many young people worldwide. In Czechia, similar rates of mental health problems in children are observed, yet access to specialised care remains limited. This paper addresses the urgent need for comprehensive support systems in Czechia by focusing on parental roles in promoting children's mental health. Despite the pivotal influence of parents on children's well-being, research specific to parental perspectives and needs in Czechia is sparse. This study employs a situational analysis and needs assessment using the Consolidated Framework for Implementation Research to explore parental perceptions of mental health, self-efficacy, stigma, and experiences with professional support. It also examines available resources and services for children, emphasising the prevalence and severity of anxiety-related concerns. By highlighting these critical aspects this study underscores the necessity of overcoming financial and accessibility barriers to evidence-based mental health programmes for families and children in Czechia, advocating for the establishment of support structures through public health insurance to reduce the treatment gap.
Teletrabalho no cenário pós-pandemia: elementos estruturais direcionadores para implantação do modelo
Authors: Caprioli Hericson , Weymer Alex Sandro Quadros 
Published: August 2024

O objetivo deste estudo foi identificar os elementos estruturais direcionadores para implantação de um modelo de teletrabalho no cenário pós-pandemia. A construção teórica se apoiou na literatura especializada sobre teletrabalho e mudança organizacional, especialmente a partir da estrutura de design proposta no modelo star model de Galbraith. A estratégia de pesquisa é do tipo estudo de caso. A técnica de análise de dados utilizada foi a análise de conteúdo das entrevistas realizadas com 24 líderes e colaboradores da cooperativa relacionados ao tema, gerando 409 citações, 58 subcategorias e cinco categorias analíticas, que foram sistematizadas com o auxílio do software atlas.ti 8.0. Após a análise dos dados, foi possível evidenciar que os principais elementos estruturais (sintéticos) para implantação do modelo de trabalho estão coerentes com as dimensões da estrutura teórica escolhida: estratégia, estrutura, processos e competência lateral, sistema de recompensas e o de pessoas. No entanto, também foi possível perceber que existem elementos estruturais (analíticos) específicos e significativos que precisam ser considerados por aquelas organizações que almejam migrar ou implantar um modelo de teletrabalho, ressalvadas as peculiaridades do contexto específico da organização cooperativa deste estudo.
Assessing the impact of socio-demographic factors on municipal water security in planned and unplanned urban centers of Pakistan
Authors: Kamran  , Khayyam Umer , Safdar Fasiha , Wahdatyar Rahmatullah , Waheed Abdul , Khokhar Muhammad Fahim 
Published: August 2024

ABSTRACT

In the current era of climate change, along with population and urbanization growth, Pakistan is facing increasing environmental challenges. These challenges intensified the pressure on the existing municipal water supply (MWS), which necessitated a need for a comprehensive assessment of the municipal water dynamics in these three cities. This research aimed sixfold: assessing the current municipal water services, municipal water demand, groundwater table depletion, satisfaction, awareness level, and the monetary indicators of the MWS. A three-stage key performance indicator (KPI) -based questionnaire survey was conducted, both online and through a field survey, self-administered between March 2022 and December 2023 in Islamabad (planned), Rawalpindi, and Mardan (unplanned). Public water supply (PWS) coverage remained 63% in Islamabad and 52% in Rawalpindi, while Mardan heavily relied on (44%) bore wells. Similarly, water scarcity remained alarmingly high in Islamabad (82%) and Rawalpindi (72%), compared to (relatively) low in Mardan (16%) between June and August every year. Over the past three decades, groundwater depths (GWD) in Rawalpindi have increased up to 300 ft, in Islamabad by 200 ft, and in Mardan by 50 ft. The study calls for intensified roles of all stakeholders, including the community, municipalities, policymakers, and urban planners, to ensure sustained municipal water supply.
Hydrological simulation and evaluation of drought conditions in the ungauged watershed Parishan lake Iran, using the SWAT model
Authors: Ansarifard Sara , Ghorbanifard Mahdi , Boustani Fardin , Abdolazimi Hadi 
Published: August 2024

ABSTRACT

Lake Parishan has experienced significant water scarcity, leading to its complete disappearance. This study utilized the SWAT model to assess the impact of changes in vegetation, precipitation, temperature, and evaporation on runoff and the lake's surface. Two strategies were employed: analyzing runoff variations based on land use and land cover (LULC) changes and evaluating the effects of precipitation, temperature, and humidity on runoff during the simulation period. A key challenge was the lack of runoff statistics, which was addressed by using data from donor watershed stations and Copernicus satellite information to improving simulation processes and calibration. The findings reveal that environmental changes, particularly land use, have increased evaporation and temperature fluctuations which results in reducing runoff. While Copernicus satellite data proved useful, runoff statistics from the neighboring Chamchit station provided more accurate simulations. The study finding suggests that the LULC strategy is an effective management approach, as in this case Parishan Lake's historical conditions with less urbanization and agriculture correlated with higher runoff and lake levels. Finally, meteorological and hydrometric drought and its impact on lake area changes were measured to reach a more comprehensive conclusion.
Mechanism of Action of NvZhen ErXian HeJi in Ovariectomized Rats with Myocardial Infarction based on Network Pharmacology
Authors: Wu Kai , Guo Shuxun , Zhang Jie , Wen Desong , Zhang Linli , Zhu Mingyang , Wang Xiulong , Li Xuefang , Chen Zhigang , Lin Fei 
Published: August 2024

Objective:
NvZhen ErXian HeJi (NZEXHJ) is used to treat perimenopausal syndrome (PS), but its
effect on perimenopausal coronary heart disease is unclear. Furthermore, the aim of this research is to study
the effect of NZEXHJ on perimenopausal coronary heart disease (PMCHD) in a rat model based on a network
pharmacology approach.

Materials and Methods:
Based on network pharmacological analysis combined with molecular docking, we
predicted the potential therapeutic target and pharmacological mechanism of NZEXHJ in the treatment of
PMCHD. We used an ovariectomized rat (OVR) model to understand the effect of NZEXHJ on myocardial injury
and further verified the target of NZEXHJ in the intervention of PMCHD.

Results:
We selected 52 active components of NZEXHJ against PMCHD and an intersection of their targets
on network pharmacology, to which SCN5A, SER1, AR, and PGR were significantly correlated. The protein-
protein interaction network revealed CASP3, CXCL8, IL6, MAPK1, TNF, TP53, and VEGFA in the treatment
of PMCHD with NZEXHJ. Kaempferol, luteolin, and mistletoe presented good affinity towards the aforementioned
targets by Molecular docking NZEXHJ exerted protecting cardiomyocytes for OVR. The mechanism
was related to a reduction in the expression levels of the CXCL8, TNF, and regulating PI3K-AKT signaling
pathways.

Conclusion:
This study reveals the potential multi-component, multi-target, and multi-pathway pharmacological
effects of NZEXHJ and predicts its protection against myocardial infarction in ovariectomized rats through
the PI3K Akt pathway, providing a theoretical basis for the treatment of PMCHD.