bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adenosine accelerates the healing of diabetic ischemic ulcers by improving autophagy of endothelial progenitor cells grown on a biomaterial
Authors: Chen Wen , Wu Yangxiao , Li Li , Yang Mingcan , Shen Lei , Liu Ge , Tan Ju , Zeng Wen , Zhu Chuhong 
Published: June 2015

AbstractEndothelial progenitor cells (EPCs) seeded on biomaterials can effectively promote diabetic ischemic wound healing. However, the function of transplanted EPCs is negatively affected by a high-glucose and ischemic microenvironment. Our experiments showed that EPC autophagy was inhibited and mitochondrial membrane potential (MMP) was increased in diabetic patients, while adenosine treatment decreased the energy requirements and increased the autophagy levels of EPCs. In animal experiments, we transplanted a biomaterial seeded with EPCs onto the surface of diabetic wounds and found that adenosine-stimulated EPCs effectively promoted wound healing. Increased microvascular genesis and survival of the transplanted cells were also observed in the adenosine-stimulated groups. Interestingly, our study showed that adenosine increased the autophagy of the transplanted EPCs seeded onto the biomaterial and maintained EPC survival at 48 and 96 hours. Moreover, we observed that adenosine induced EPC differentiation through increasing the level of autophagy. In conclusion, our study indicated that adenosine-stimulated EPCs seeded onto a biomaterial significantly improved wound healing in diabetic mice; mechanistically, adenosine might maintain EPC survival and differentiation by increasing high glucose-inhibited EPC autophagy and maintaining cellular energy metabolism.
An Alternative Phosphorylation Switch in Integrin β2 (CD18) Tail for Dok1 Binding
Authors: Gupta Sebanti , Chit Joel Chia-Yeong , Feng Chen , Bhunia Anirban , Tan Suet-Mien , Bhattacharjya Surajit 
Published: June 2015

AbstractIntegrins are involved in cell migration and adhesion. A large number of proteins interact with the cytoplasmic tails of integrins. Dok1 is a negative regulator of integrin activation and it binds to the phosphorylated membrane proximal NxxY motif in a number of integrin β tails. The β tail of the β2 integrins contains a non-phosphorylatable NxxF motif. Hence it is unclear how Dok1 associates with the β2 integrins. We showed in this study using NMR and cell based analyses that residues Ser745 and Ser756 in the integrin β2 tail, which are adjacent to the NxxF motif, are required for Dok1 interaction. NMR analyses detected significant chemical shift changes and higher affinity interactions between Dok1 phospho-tyrosine binding (PTB) domain and integrin β2 tail peptide containing pSer756 compared to pSer745. The phosphorylated β2 peptide occupies the canonical ligand binding pocket of Dok1 based on the docked structure of the β2 tail-Dok1 PTB complex. Taken together, our data suggest an alternate phosphorylation switch in β2 integrins that regulates Dok1 binding. This could be important for cells of the immune system and their functions.
Demonstrating quantum contextuality of indistinguishable particles by a single family of noncontextuality inequalities
Authors: Su Hong-Yi , Chen Jing-Ling , Liang Yeong-Cherng 
Published: June 2015

AbstractQuantum theory has the intriguing feature that is inconsistent with noncontextual hidden variable models, for which the outcome of a measurement does not depend on which other compatible measurements are being performed concurrently. While various proofs of such contextual behavior of quantum systems have been established, relatively little is known concerning the possibility to demonstrate this intriguing feature for indistinguishable particles. Here, we show in a simple and systematic manner that with projective measurements alone, it is possible to demonstrate quantum contextuality for such systems of arbitrary Hilbert space dimensions, including those corresponding to a qubit. Our demonstration is applicable to a single fermion as well as multiple fermions and thus also a composite boson formed from an even number of fermions. In addition, our approach gives a clear demonstration of the intimate connection between complementarity and contextuality, two seemingly unrelated aspects of quantum theory.
Microelectromechanically tunable multiband metamaterial with preserved isotropy
Authors: Pitchappa Prakash , Ho Chong Pei , Qian You , Dhakar Lokesh , Singh Navab , Lee Chengkuo 
Published: June 2015

AbstractWe experimentally demonstrate a micromachined reconfigurable metamaterial with polarization independent characteristics for multiple resonances in terahertz spectral region. The metamaterial unit cell consists of eight out-of-plane deformable microcantilevers placed at each corner of an octagon ring. The octagon shaped unit cell geometry provides the desired rotational symmetry, while the out-of-plane movable cantilevers preserves the symmetry at different configurations of the metamaterial. The metamaterial is shown to provide polarization independent response for both electrical inductive-capacitive (eLC) resonance and dipolar resonance at all states of actuation. The proposed metamaterial has a switching range of 0.16 THz and 0.37 THz and a transmission intensity change of more than 0.2 and 0.7 for the eLC and dipolar resonances, respectively for both TE and TM modes. Further optimization of the metal layer thickness, provides an improvement of up to 80% modulation at 0.57 THz. The simultaneously tunable dual band isotropic metamaterial will enable the realization of high performance electro-optic devices that would facilitate numerous terahertz applications such as compressive terahertz imaging, miniaturized terahertz spectroscopy and next generation high speed wireless communication possible in the near future.
SNP rs2057482 in HIF1A gene predicts clinical outcome of aggressive hepatocellular carcinoma patients after surgery
Authors: Guo Xu , Li Deyang , Chen Yibing , An Jiaze , Wang Kan , Xu Zhuding , Chen Zhinan , Xing Jinliang 
Published: June 2015

AbstractHypoxia-inducible factor 1α (HIF-1α) plays an important role in tumor growth and metastasis. Genetic variations of HIF1A gene have been shown to influence the developing risk and prognosis in many types of human malignancies. However, their association with clinical outcomes of hepatocellular carcinoma (HCC) patients remains unclear. To investigate the predictive role of single nucleotide polymorphisms (SNPs) in HIF1A gene in HCC patients’ outcomes, we genotyped three functional SNPs (rs2057482, rs1957757 and rs2301113) in HIF1A gene and assessed their associations with clinicopathological parameters and prognosis of 492 surgical HCC patients. The patients with variant alleles (CT+TT) of SNP rs2057482 had a significantly lower recurrence risk when compared with patients with the CC genotype. In stratified analysis, the protective effect of rs2057482 CT+TT genotype was more evident in patients with adverse strata, compared with patients with favorable strata. Additionally, strong joint predictive effect between rs2057482 genotypes and AFP level, stage or differentiation were observed. Functional assay also indicated the significant effect of rs2057482 on gene expression. In conclusion, SNP rs2057482 in HIF1A gene is significantly associated with clinical outcomes of Chinese HCC patients after surgery, especially in those with aggressive status, which warrants further validation in other patient populations.
Effect of Amplification on Speech and Language in Children With Aural Atresia
Authors: Attaway Judy , Stone Christopher L. , Sendor Cindy , Rosario Emily R. 
Published: June 2015

Purpose
There currently is no guideline regarding amplification or verification for children with aural atresia. This population, with the absence of the ear canal, has obvious congenital hearing loss. Research suggests that delayed treatment for hearing loss can result in speech and language impairments, including poor performance in school. In this study we examined the relationship between amplification and emerging speech and language development in children with aural atresia.

Method
Subjects included children, 3 to 6 years of age, with conductive hearing loss due to atresia. Clinical evaluations were used to determine relationships between amplification and speech and language development. Subjects underwent an audiology exam, including pure-tone or warble-tone air and bone conduction using play audiometry techniques, and a speech and language evaluation assessing language and vocabulary skills.

Results
Subjects who were fitted before 1 year of age showed better compliance with aid use and exhibited fewer delays in speech and language development. Children with right-sided atresia had significantly greater speech and language delays when compared with age norms from standardized tests.

Conclusion
Our findings highlight a relationship between side of atresia, time of first amplification, compliance in aid use, and speech and language abilities.
Measurement and analysis of multiband bistatic and monostatic radar signatures of wind turbines
Authors: Ritchie M. , Fioranelli F. , Balleri A. , Griffiths H.D. 
Published: June 2015

The results of recent measurements taken with two radar systems to measure the simultaneous monostatic and bistatic signature of wind turbines, at S‐band and X‐band are presented. Coherent monostatic and bistatic data was collected with the University College London (UCL) NetRAD 2.4 GHz radar, and the Cranfield University CW radar operating at X‐band. Initial analysis shows the bistatic Doppler signature of wind turbines and informs on the key differences seen at modest bistatic angles. Polarimetric variations are also analysed via data gathered from using co‐polarised VV and HH and cross‐polarised VH components.
The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation
Authors: Pastori Chiara , Kapranov Philipp , Penas Clara , Peschansky Veronica , Volmar Claude-Henry , Sarkaria Jann N. , Bregy Amade , Komotar Ricardo , St. Laurent Georges , Ayad Nagi G. , Wahlestedt Claes 
Published: June 2015

Significance
Glioblastoma Multiforme (GBM) is the most common and deadliest primary brain tumor in adults. As the median survival is approximately 14 mo there is an urgent need for novel therapies. Epigenetic modulators such as bromodomain and extraterminal (BET) proteins are important therapeutic targets in GBM. Bromodomain inhibitors (including I-BET151) suppress proliferation by repressing oncogenes and inducing tumor suppressor genes through unidentified pathways. Here we demonstrate that HOTAIR (HOX transcript antisense RNA) is overexpressed in GBM, where it is crucial to sustain tumor cell proliferation, and that inhibition of HOTAIR by I-BET151 is necessary to induce cell cycle arrest in GBM cells. Our study outlines the mechanism of action underlying the antiproliferative activity of I-BET151, showing for the first time, to our knowledge, that the oncogenic long noncoding RNA HOTAIR is a major target.
New ways of building, showcasing, and measuring scholarly reputation
Authors: NICHOLAS David , HERMAN Eti , JAMALI Hamid , RODRÍGUEZ‐BRAVO Blanca , BOUKACEM‐ZEGHMOURI Cherifa , DOBROWOLSKI Tom , POUCHOT Stephanie 
Published: June 2015

ABSTRACTThe article reports on a study of the views and actions of nearly a hundred scholars – mostly academic researchers from four European countries and four disciplines – in regard to scholarly reputation in the Science 2.0 age. It specifically looks at the role that 'emerging reputational mechanisms and platforms are playing in building, maintaining, and showcasing scholarly reputation in the digital age. Popular examples of such platforms are ResearchGate and Academia.edu. Data were obtained through one‐to‐one interviews and focus groups, supported by desk research. The main findings were: (a) it is early days and uptake is light and patchy with platforms largely used for non‐reputational purposes, such as sharing documents; (b) most users were passive and did not fully engage with the social aspects of the platforms; (c) the reputational focus was very much on just one scholarly activity (research), on just two outputs of that activity (publications and conferences) and one measurement of that activity (citations), but there are the stirrings of change; (d) young researchers are set to profit most from the emerging platforms.
Academic publishing career paths — initial research and observations
Authors: CARDEN Mark 
Published: June 2015

ABSTRACTThe job titles and career paths of people transitioning between academia and scholarly publishing, and of those who are progressing within their publishing careers, has been little studied and lacks accepted frameworks, ‘route‐maps’, and taxonomies. Much of the work done to date provides merely a ‘snapshot’ of the current demographics of the publishing workforce at particular moment, and tends not to offer insight into pathways, trajectories, or momentum. This preliminary survey, involving around 150 scholarly publishers, reveals insights into job titles, progressions, and transitions, and exposes some of the reasons for transitions between academia and publishing. The analysis suggests that these transitions and career paths can be systematically studied and documented, for use both by individuals considering their own careers, and by planners and managers in academic institutions and scholarly publishing organizations.
Non-Dipping Pattern and Subclinical Cardiac Damage in Untreated Hypertension: A Systematic Review and Meta-Analysis of Echocardiographic Studies
Authors: Cuspidi Cesare , Sala Carla , Tadic Marijana , Rescaldani Marta , Grassi Guido , Mancia Giuseppe 
Published: June 2015

Abstract

AIM
The association of non-dipping (ND) pattern with cardiac damage is debated. We performed a meta-analysis in order to provide comprehensive information on subclinical cardiac alterations in untreated ND hypertensives.

DESIGN
A computerized search was performed using PubMed, OVID, EMBASE, and Cochrane library databases from 1 January 1990 up to 31 October 2014. Full articles published in English language providing data on subclinical cardiac damage in ND as compared to dipper (D) hypertensives, as assessed by echocardiography, were considered.

RESULTS
A total of 3,591 untreated adult subjects (1,291 ND and 2,300 D hypertensives) included in 23 studies were considered. Left ventricular (LV) mass index (LVMI) was higher in ND than in D hypertensives (122±3.8g/m2 vs. 111±3.3g/m2, standardized mean difference, SMD: 0.40±0.07, confidence interval (CI): 0.26–0.53, P &lt; 0.001); relative wall thickness (RWT) and left atrium (LA) diameter were greater (SMD: 0.14±0.005, CI: 0.05–0.23, P = 0.002; 0.36±0.10, CI: 0.16–0.56, P &lt; 0.001, respectively), while mitral E/A ratio was lower in ND than in D counterparts (SMD: −0.23±0.08, CI: −0.39 to −0.08, P = 0.003). After assessing data for publication bias, the difference between groups was still significant, with the exception of E/A ratio.

CONCLUSIONS
Our meta-analysis supports an association between ND pattern and increased risk of LV structural alterations in untreated essential hypertensives. This observation supports the view that an effective BP control throughout the entire 24-hour cycle may have a key role in preventing or regressing subclinical cardiac damage associated to ND pattern.
The center for expanded data annotation and retrieval
Authors: Musen Mark A , Bean Carol A , Cheung Kei-Hoi , Dumontier Michel , Durante Kim A , Gevaert Olivier , Gonzalez-Beltran Alejandra , Khatri Purvesh , Kleinstein Steven H , O’Connor Martin J , Pouliot Yannick , Rocca-Serra Philippe , Sansone Susanna-Assunta , Wiser Jeffrey A ,   and the CEDAR team
Published: June 2015

Abstract
The Center for Expanded Data Annotation and Retrieval is studying the creation of comprehensive and expressive metadata for biomedical datasets to facilitate data discovery, data interpretation, and data reuse. We take advantage of emerging community-based standard templates for describing different kinds of biomedical datasets, and we investigate the use of computational techniques to help investigators to assemble templates and to fill in their values. We are creating a repository of metadata from which we plan to identify metadata patterns that will drive predictive data entry when filling in metadata templates. The metadata repository not only will capture annotations specified when experimental datasets are initially created, but also will incorporate links to the published literature, including secondary analyses and possible refinements or retractions of experimental interpretations. By working initially with the Human Immunology Project Consortium and the developers of the ImmPort data repository, we are developing and evaluating an end-to-end solution to the problems of metadata authoring and management that will generalize to other data-management environments.
Disability in Children and Adolescents With Irritable Bowel Syndrome and/or Fibromyalgia
Authors: Otu‐Nyarko Charles G. , Gedalia Abraham , Karpinski Aryn C. , Kolomensky Andrew , Hyman Paul E. 
Published: June 2015

ABSTRACTTo compare disability and emotional health in individuals with irritable bowel syndrome (IBS), fibromyalgia, or both, patients completed the Questionnaire on Pediatric Gastrointestinal Symptoms—Rome III, childhood Functional Disability Inventory (FDI), and the Behavior Assessment System for Children, Second Edition. Patients’ (age range 8–18 years, 19 IBS, 12 fibromyalgia, and 12 both) FDI scores showed greater disability than scores from historically healthy patients. Fibromyalgia (FDI 22.5 ± 12.7, P = 0.018) and patients with both (FDI 26.2 ± 13.8, P = 0.001) averaged greater disability than those with IBS (FDI 10.6 ± 7.9). Disability was correlated with anxiety and depression symptoms. Disability and psychological symptoms are important when evaluating individuals with fibromyalgia and IBS.
Intermittent Bolus or Semicontinuous Feeding for Preterm Infants?
Authors: Rövekamp‐Abels Lyanne W.W. , Hogewind‐Schoonenboom Jacomine E. , de Wijs‐Meijler Daphne P.M. , Maduro Margaux D. , Jansen‐van der Weide Marijke C. , van Goudoever Johannes B. , Hulst Jessie M. 
Published: June 2015

ABSTRACTObjectives:The aim of the present study was to assess the clinical benefits and risks of semicontinuous (CON) versus intermittent nasogastric tube feeding in low‐birth‐weight infants.Methods:Infants with a birth weight <1750 g and gestational age <32 weeks were stratified according to birth weight and assigned to either CON or intermittent bolus (BOL) feeding. The primary endpoint was days to full enteral feeding (defined as 120 mL · kg−1 · day−1). We also collected data on feeding tolerance, weight gain, respiratory support, and complications (sepsis, necrotising enterocolitis, and death).Results:There was no difference between the 2 groups (CON n = 121, BOL n = 125) in days to reach full enteral feeding—7 (5–10) versus 6 (5–8) days, respectively, with a difference 1 (−0.05 to 2.1). Mean daily gastric residual volumes, however, were significantly lower in the BOL group (4.8 vs 3.9 mL/day, difference 0.9 mL/day [0.1–1.7]), as was the total number of patients with feeding interruptions (76 vs 59, difference 16% [3%–28%]).Conclusions:Bolus and continuous feeding are equally suitable feeding strategies for preterm neonates. BOL feeding, however, may be preferable.
Competition against common sense
Authors: Komarova  Loureiro Yuliya , Gonzalez Laura 
Published: June 2015

Purpose
– The purpose of this paper is to provide insights into peer-to-peer (P2P) lending which has served as one important tool to mitigate financial exclusion. The main proposition of this research is that P2P platforms, which in many ways resemble auctions, naturally instill competitive mindset among lenders; furthermore, given only limited objective decision criteria, certain borrower personal characteristics fuel interpersonal competition enough to impact lending decisions in suboptimal ways. The two experiments support this proposition. As the result, while P2P lending offers unprecedented financial opportunities to some consumer groups, it may unintentionally exclude others, and even pose threat to the financial well-being of lenders.

Design/methodology/approach
– Two experiments were used to collect data and are reported here. Rigorous pretesting of manipulation stimuli preceded a pilot (exploratory) and the main experiment.

Findings
– The authors generally find a significant age bias, where ceteris paribus, younger borrowers are offered lower loan amounts as lenders most likely infer greater risk and lower likelihood to repay loans on time. However, and perhaps more interestingly, when age is not a strong indicator of experience (as in the case with 30 something), the authors repeatedly find evidence of lending decisions driven by interpersonal competition: more attractive and financially successful loan applicants of the same gender as lenders are most likely perceived as a personal threat, decreasing lenders’ confidence, which subsequently results in lower amounts being invested into loans that are possibly the most promising.

Originality/value
– To the best knowledge, this research is first to demonstrate the impact of interpersonal competition on decision making in the context of P2P lending. Furthermore, this paper contributes to better understanding of P2P lending as a tool to allay financial exclusion, while raising concerns of possible unintended exclusion of certain consumer segments due to the competitive nature of P2P platforms.
A framework for leading change in the UAE public sector
Authors: Bin Taher Nader Asaad , Krotov Vlad , Silva Leiser 
Published: June 2015

Purpose
– The purpose of this paper is to guide managers on business process reengineering (BPR) and automation projects in the United Arab Emirates (UAE) public sector context.

Design/methodology/approach
– This paper relies on a literature review and synthesis in the areas of leadership, BPR, change management, user resistance and power to propose a change management framework.

Findings
– The paper argues for attention to be paid to the power relationships among various stakeholders. Stakeholder impact analysis is recommended to understand how change will impact stakeholders and shift power balances. It proposes that leadership and communication are essential for implementing change, especially given the particular cultural conditions of the UAE. Moreover, change should be a continuous process supported by communication.

Research limitations/implications
– As power and authority are very important elements of the UAE culture, future research should further examine the role of power in implementing organizational change in the UAE context.

Practical implications
– This paper proposes a ten-step change management framework that adopts the latest thinking on change management to the UAE context.

Originality/value
– Although change management is a well-established field, the body of knowledge that concentrates on the UAE organizational context is scant. This paper translates the latest thinking on change management to the UAE context (characterized by sensitivity to power issues and stakeholder impact) and proposes a practical framework for leading change in the UAE public sector context.