bluuebunny/crossref_metadata_2025_split huggingface dataset:
A knowledge‐based system for process family planning
Authors: Zhang Linda L. , Xu Qianli , Helo Petri 
Published: January 2013

PurposeThe purpose of this paper is twofold. First, it is to introduce a knowledge‐based system for planning processes for families of final products, instead of component items, be they parts or assemblies. Second, it is to demonstrate the feasibility and potential of a prototypical system developed for planning processes families for truck families from a multinational company.Design/methodology/approachThe authors first identify the challenges in planning process families, including data and knowledge representation and constraint handling. To accommodate these challenges, the paper adopts the integrated product and process structure (IP2S) and colored timed Petri nets (CTPNs) in the proposed knowledge‐based process family planning system. On top of the IP2S and CTPNs, XML‐based knowledge representation is employed to alleviate the difficulties in modelling complex product and process family data and planning knowledge while enabling information exchange across different operating platforms. In addition, in accordance with the correspondence between PNs and knowledge‐based systems, a mechanism is designed to cope with the generation of production rules, which model constraints.FindingsThe proposed system is able to automatically generate production processes for customized products. At a higher level, such production processes provide input (e.g. operations, machines) to downstream activities for planning process details to manufacture component parts or component assemblies.Research limitations/implicationsTraditional trial and error approaches to planning processes limit production performance improvement when companies need to timely produce diverse customized products. Knowledge‐based systems should be developed to help companies better plan production processes based on the available manufacturing resources.Originality/valueUnlike most reported studies addressing either detailed process planning or assembly planning for component parts or component assemblies, this study tackles process planning for final products, in attempting to maintain production efficiency from a holistic view.
Validating image in the information age
Authors: Grieve Deborah 
Published: January 2013

PurposeThe purpose of this paper is to explore how tourism and hospitality images are validated and checked to ensure accuracy through the use of online resources. These refined images ultimately impact on buying patterns.Design/methodology/approachThe author reviews the literature on the role of social media and uses in‐depth interviews to gain a deeper understanding of how technology is used to check images.FindingsA clear pattern to image formation is clear when image‐validators seek general insights from past customers and then refine images to build a final tight short‐list of options which is checked directly with members of a personal online social network.Practical implicationsWith a greater understanding of image‐validation, it is hoped that DMOs and hotels will use the more generic sites to allow past customers to upload their own reviews and comments.Originality/valueWhilst there is a lot of information on the use of the internet and social media, specific research into image validation is very limited, as far as the author is aware.
IL‐33/ST2 signalling contributes to carrageenin‐induced innate inflammation and inflammatory pain: role of cytokines, endothelin‐1 and prostaglandin E2
Authors: Zarpelon AC , Cunha TM , Alves‐Filho JC , Pinto LG , Ferreira SH , McInnes IB , Xu D , Liew FY , Cunha FQ , Verri WA 
Published: January 2013

Background and PurposeIL‐33 signals through ST2 receptors and induces adaptive and innate inflammation. IL‐33/ST2 is involved in adaptive inflammation‐induced pain. Here, we have investigated the contribution of IL‐33/ST2‐triggered mechanisms to carrageenin‐induced innate inflammation.Experimental ApproachCarrageenin‐ and IL–33‐induced inflammatory responses were assessed in BALB/c‐ (WT) and ST2‐deficient (−/−) mice as follows: oedema (plethysmometer), myeloperoxidase activity (colorimetric assay), mechanical hyperalgesia (electronic version of von Frey filaments), cytokine levels (ELISA), PGE2 (RIA), mRNA expression (quantitative PCR), drug treatments targeting leukocyte recruitment (fucoidin), TNF‐α (infliximab), CXCL1 (antibody to CXCL1), IL‐1 (IL‐1ra), endothelin ETA (clazosentan) and ETB (BQ788) receptors and COX (indomethacin).Key ResultsCarrageenin injection increased ST2 and IL‐33 mRNA expression and IL‐33 production in paw skin samples. Carrageenin‐induced paw oedema, hyperalgesia and myeloperoxidase activity were reduced in ST2−/− compared with WT mice, effects mimicked by IL‐33 injection in the paw. Furthermore, IL–33‐induced hyperalgesia was reduced by fucoidin suggesting a role for recruited leukocytes in its hyperalgesic effect. IL–33‐induced hyperalgesia in naïve mice was reduced by treatments targeting TNF, CXCL1, IL‐1, endothelin receptors and COX while carrageenin‐induced ST2‐dependent TNF‐α, CXCL1, IL‐1β, IL‐10 and PGE2 production and preproET‐1 mRNA expression. Combining IL‐33 and carrageenin at doses that were ineffective as single treatment induced significant hyperalgesia, oedema, myeloperoxidase activity and cytokine production in a ST2‐dependent manner.Conclusions and ImplicationsIL‐33/ST2 signalling triggers the production of inflammatory mediators contributing to carrageenin‐induced inflammation. These data reinforces the importance of IL‐33/ST2 signalling as a target in innate inflammation and inflammatory pain.
The history of childhood trauma among individuals with ultra high risk for psychosis is as common as among patients with first‐episode schizophrenia
Authors: Şahin Seda , Yüksel Çağrı , Güler Julide , Karadayı Gülşah , Akturan Elçin , Göde Evrim , Özhan Amber Alix , Üçok Alp 
Published: January 2013

AbstractAimChildhood trauma (CT) is more common in patients with psychosis than in general population and is found to be related to the severity of symptoms. The objective of this study was to investigate the severity of CT, and its relationship with clinical features in two different groups: first‐episode schizophrenia (FES) and ultra high risk for psychosis (UHR) groups.MethodsIn this cross‐sectional study, 83 patients with FES, 41 individuals with UHR and 69 healthy controls were included. Clinical features were evaluated with the Brief Psychiatric Rating Scale, the Scale for the Assessment of Negative Symptoms and the Scale for the Assessment of Positive Symptoms (SAPS). We evaluated CT with the Childhood Trauma Questionnaire (CTQ). UHR group was also assessed with the Calgary Depression Scale for Schizophrenia.ResultsThe emotional and physical abuse, physical and emotionalneglect subscale scores and CTQ total score of both the UHR group and FES group were higher than the control group. However, the CTQ total score and subscale scores did not differ between FES and UHR groups. UHR group had more Schneiderian symptoms in terms of both number and severity, and severity of sexual abuse was found to be correlated with SAPS scores especially for the ‘commenting voices’ item. The CTQ emotional abuse and neglect scores were correlated with the severity of depression. FES patients with higher CTQ scores obtained higher total scores on SAPS and higher total scores on Schneiderian items.ConclusionWe found that CT is related to the severity of psychotic symptoms in both FES and UHR groups. Therefore, it is possible that interventions aimed at preventing CT in children would reduce the manifestation of psychosis among young people.
Cognitive insight in individuals at clinical high risk for psychosis
Authors: Kimhy David , Jobson‐Ahmed Lauren , Ben‐David Shelly , Ramadhar Lisa , Malaspina Dolores , Corcoran Cheryl M. 
Published: January 2013

AbstractAimReduced cognitive insight has been associated with psychotic symptoms, in particular with the presence of delusions; however, there is little information about whether such reductions are present in at‐risk individuals prior to the onset of threshold psychotic symptoms.MethodWe conducted a cross‐sectional comparison of cognitive insight (as indexed by the Beck Cognitive Insight Scale) in 62 help‐seeking individuals at clinical high risk for psychosis, Fifty‐nine individuals with schizophrenia‐spectrum disorders and 37 healthy controls (HC). In patients, we evaluated associations of insight with positive symptoms, including later transition to psychosis in high‐risk patients.ResultsIndividuals with schizophrenia reported significantly higher self‐certainty scores than the at‐risk patients and HCs, with the at‐risk patients scoring intermediate to the individuals with schizophrenia andcontrols. Similarly, individuals with schizophrenia scored significantly higher on self‐reflectiveness, with no differences between the at‐risk patients and controls. In individuals with schizophrenia, delusions were significantly correlated with self‐certainty. In at‐risk patients, cognitive insight was not associated with positive symptom severity and did not differentiate those at‐risk patients who later developed psychosis from those who did not. However, post hoc analyses suggested that at‐risk patients with marked unusual thought content (approaching threshold psychosis) had lower self‐reflectiveness; whereas those with high suspiciousness had significantly higher self‐certainty.ConclusionsThe findings are discussed in the context of normal developmental processes occurring during adolescence, their putative links to neurobiological functioning, and their implications for treatment and future research.
Preclinical evaluation of Sunitinib as a single agent in the prophylactic setting in a mouse model of bone metastases
Authors: Schem Christian , Bauerschlag Dirk , Bender Sascha , Lorenzen Ann-Christin , Loermann Daniel , Hamann Sigrid , Rösel Frank , Kalthoff Holger , Glüer Claus C , Jonat Walter , Tiwari Sanjay 
Published: January 2013

Abstract

Background
A substantial number of breast cancer patients are identified as being at high risk of developing metastatic disease. With increasing number of targeted therapeutics entering clinical trials, chronic administration of these agents may be a feasible approach for the prevention of metastases within this subgroup of patients. In this preclinical study we examined whether Sunitinib, a multi-tyrosine kinase inhibitor which has anti-angiogenic and anti-resorptive activity, is effective in the prevention of bone metastases.

Method
Sunitinib was administered daily with the first dose commencing prior to tumor cell inoculation. Intracardiac injection was performed with MDA-MB23 bone-seeking cells, which were stably transfected with DsRed2. In vivo plain radiography and fluorescent imaging (Berthold NightOwl) was used in the analysis of bone metastases. Histomorphometry was used for the quantification of TRAP+ cells from bone sections and immunohistochemistry was performed using an antibody reactive to CD34 for quantification of microvessel density.

Results
Preventive dosing administration of Sunitinib does not inhibit colonization of tumor cells to bone or reduce the size of osteolytic lesions. There was a decrease in the number of TRAP+ cells with Sunitinib treatment but this did not reach significance. Sunitinib inhibited tumor growth as determined by imaging of fluorescent tumor area. Immunohistochemical analyses of microvessel density revealed a concomitant decrease in the number of tumor blood vessels.

Conclusions
The findings suggest that Sunitinib can be used as a therapeutic agent for the treatment of bone metastases but as a single agent it is not effective in terms of prevention. Therefore a combination approach with other cytostatic drugs should be pursued.
Eco‐Friendly Approach to Ultra‐Thin Metal Oxides‐ Solution Sheared Aluminum Oxide for Half‐Volt Operation of Organic Field‐Effect Transistors
Authors: Dacha Preetam , Haase Katherina , Wrzesińska‐Lashkova Angelika , Pohl Darius , Maletz Roman , Millek Vojtech , Tahn Alexander , Rellinghaus Bernd , Dornack Christina , Vaynzof Yana , Hambsch Mike , Mannsfeld Stefan C. B. 
Published: July 2024

AbstractSol–gel‐based solution‐processed metal oxides have emerged as a key fabrication method for applications in thin film transistors both as a semiconducting and a dielectric layer. Here, a low‐temperature, green solvent‐based, non‐toxic, and cost‐effective solution shearing approach for the fabrication of thin aluminum oxide (AlOx) dielectrics is reported. Optimization of sustainability aspects like energy demand, and selection of chemicals used allows to reduce the environmental impact of the life cycle of the resulting product already in the design phase. Using this approach, ultra‐thin, device‐grade AlOx films of 7 nm are coated—the thinnest films to be reported for any solution‐fabrication method. The metal oxide formation is achieved by both thermal annealing and deep ultra‐violet (UV) light exposure techniques, resulting in capacitances of 750 and 600 nF cm−2, respectively. The structural analysis using microscopy and x‐ray spectroscopy techniques confirmed the formation of smooth, ultra‐thin AlOx films. These thin films are employed in organic field‐effect transistors (OFETs) resulting in stable, low hysteresis devices leading to high mobilities (6.1 ± 0.9 cm2 V−1 s−1), near zero threshold voltage (−0.14 ± 0.07 V) and a low subthreshold swing (96 ± 16 mV dec−1), enabling device operation at only ±0.5 V with a good Ion/Ioff ratio (3.7 × 105).
Flying‐Saucer‐Shaped Nanoheterojunctions with Enhanced Colorectal Tumor Accumulation for Increased Oxidative Stress and Immunometabolic Regulation
Authors: Ma Ya , Cao Yingui , Zu Menghang , Gao Qiang , Liu Ga , Ji Jianying , Xu Haiting , Yang Qiang , Shi Xiaoxiao , Reis Rui L. , Kundu Subhas C. , Zheng Ji , Li Zhou , Xiao Bo 
Published: July 2024

AbstractThe treatment outcomes of nanomedicines against colorectal cancer are severely restricted by their insufficient accumulation in the tumor tissues, unsatisfactory antitumor effect, and weak immunometabolic modulation. To address these issues, flying‐saucer‐shaped nanoheterojunctions by coating copper oxide (CuxO) onto the surface of PEGylated zinc oxide (ZnO) nanoparticles are constructed. When exposed to ultrasound, the resultant CuxO@ZnO nanoheterojunctions exhibit increased locomotor activities, facilitating colorectal mucus infiltration, deep tumor penetration, and tumor cell internalization. The decoration of CuxO suppresses the rapid recombination of electrons and holes in CuxO@ZnO exposed to ultrasound, promoting the production of singlet oxygen and hydroxyl radical, which are generated by CuxO through a Fenton‐like chemodynamic reaction and CuxO@ZnO through sonodynamic reaction. After rectal administration, the sono‐chemodynamic CuxO@ZnO plus PD‐L1 antibodies effectively inhibit the growth of orthotopic and distant tumors. It elicits immunometabolic responses by inducing immunogenic cell death, activating the interferon genes signaling pathway stimulator, and inhibiting glucose transport and the glycolytic signaling pathways. This combined modality also increases the proportion of beneficial microbes (e.g., Bifidobacterium) and decreases the abundance of harmful microorganisms (e.g., Romboutsia) in the intestine. This treatment modality (CuxO@ZnO plus ultrasound and PD‐L1 antibodies) is a promising strategy for the synergistic treatment of colorectal cancer.
Achieving Overall Carbon Utilization from Organic Wastewater to Recover Solar Syngas via an Artificial Carbon Cycling System
Authors: Wu Xi , Li Jiabi , Zhong Ruiyu , Liu Shengwei , Huang Fei , Yang Qiaoling , Zhang Bin , Wang Xin , Zhang Fuxiang 
Published: June 2024

AbstractBuilding artificial carbon cycling systems for the direct conversion of wastewater into value‐added solar fuels using renewable solar energy can contribute to achieving carbon neutrality. Herein, a bifunctional photocatalyst comprising three‐dimensionally ordered Ti3C2Tx/TiO2 nanoflowers is exploited for tandem carbon cycling systems to achieve efficient organic wastewater treatment with simultaneous CO2 resourcing. The highest efficiency is achieved by using the optimal Ti3C2Tx/TiO2 photocatalyst to treat simulated wastewater containing rhodamine B (RhB), with an enhanced primary CO production rate of 10.02 µmol g−1 h−1 and RhB degradation efficiency of 77.6% after 1 h of illumination in an anoxic environment. The CO/H2 ratio of the produced syngas can be readily tuned from 0.95 to 1.86 by adjusting the Ti3C2Tx content. Mechanistic studies based on DFT, in situ DRIFTS, and LC‐MS2/IC reveal that the coupled photocatalytic RhB degradation and CO2 reduction processes collectively undertake *HCOO intermediate coverage. This phenomenon triggers the sustainable and simultaneous conversion of *CO2 and *HCOO into CO under mild conditions and crosses the key rate‐limiting step of CO2‐to‐CO conversion, thereby achieving overall carbon utilization from organic wastewater treatment. This study offers in‐depth insights into the design and mechanisms of highly effective carbon utilization in artificial carbon cycling systems.
Nature‐Inspired Incorporation of Precipitants into High‐Strength Bulk Aluminum Alloys Enables Life‐Long Extraordinary Corrosion Resistance in Diverse Aqueous Environments
Authors: Wang Zhengbin , Yang Jie , Xiao Zhixiang , Liu Zhenyu , Xiao Bolv , Ma Zongyi , Cheng Hui‐Ming , Zheng Yugui 
Published: June 2024

AbstractThe safe service and wide applications of lightweight high‐strength aluminum alloys are seriously challenged by diverse environmental corrosion, since high strength and corrosion resistance are mutually exclusive for metals while surface protection cannot provide life‐long corrosion resistance. Here, inspired by fish secreting slime from glands to resist external changes, a strategy of incorporating precipitants as the slime into bulk metals using the inner cavity of opened carbon nanotubes (CNTs) as the glands is developed to enable high‐strength aluminum alloys with life‐long superior corrosion resistance. The resulting material has ultrahigh tensile strength (≈700 MPa) and extraordinary corrosion resistance in acidic, neutral and alkaline media. Notably, it has the highest resistance to intergranular corrosion, exfoliation corrosion and stress‐corrosion cracking, compared with all previously reported aluminum alloys, and its corrosion rate is even much lower than that of corrosion‐resistant pure aluminum, which results from the pronounced surface enrichment of precipitants released (secreted) from exposed CNTs forming a protective surface film. Such high corrosion resistance is life‐long and self‐healing due to the on‐demand minimal self‐supply of the precipitants dispersed throughout the bulk material. This strategy can be readily expanded to other aluminum alloys, and could pave the way for developing corrosion‐resistant high‐strength metallic materials.
Nature‐Inspired Strategy: Novel Borohydride‐Based Solid Electrolytes Extracted from Cathode‐Electrolyte Interphase
Authors: Yin Yuhang , Yan Fei , Li Shuyang , Chen Yufan , Guo Dingcheng , Zhao Jie , Sun Dalin , Fang Fang , Song Yun 
Published: June 2024

AbstractAs the core component of all‐solid‐state batteries, current solid‐state electrolytes fail to simultaneously meet multiple demands, such as their own high performance, the chemical, electrochemical and mechanical compatibility of electrode interface. A fresh perspective is rather desired to guide the development of novel solid electrolytes with comprehensive performance. Herein, this work proposes a novel strategy to synthesize solid electrolytes extracted from cathode‐electrolyte interphase (CEI), which is inspired by peach trees secreting peach gum to prevent further damage. A proof‐of‐concept, using LiBH4‐Se and LiBH4‐S as prototypes, confirms that as‐synthesized electrolytes inherited and improved up the advantages of LiBH4 with unexpected compatibility toward multiple cathodes. It is believed that the family of new electrolytes will be continuously expanded under the guidance of this CEI‐derived concept.
Palladium‐Catalyzed Sc(OTf)3/Cs2CO3‐Assisted C−O Cross‐Coupling of Vinylidenecyclopropane‐Diesters with Phenolic Compounds
Authors: Zhong Xian‐Hua , Long Yong‐Jie , Wei Yin , Shi Min 
Published: July 2024

AbstractWe herein describe a method in the synthesis of aryl ether derivatives from a cross‐coupling reaction of vinylidenecyclopropane‐diesters (VDCP‐diesters) with commercially available phenolic compounds for the formation of C−O bond under palladium catalysis and assisted by Sc(OTf)3/Cs2CO3. This developed transformation proceeds through a nucleophilic addition at the 2‐position of allenic moiety at 50 °C for 4.0 h and is compatible with substituents such as bromine, iodine and borate on the phenolic substrates via a zwitterionic π‐propargyl palladium species, affording the desired products in 29% to 95% isolated yields. A plausible reaction mechanism has been also proposed on the basis of control, deuterium labeling experiments and density functional theory (DFT) calculations.
Nickel‐Catalyzed Regio‐ and Stereoselective Reductive Alkylative Cyclization of 1,6‐Enynes with Alkyl Bromides
Authors: Xing Yunxin , Tian Zhu , Shen Kun 
Published: July 2024

AbstractA nickel‐catalyzed reductive alkylative cyclization of 1,6‐enynes with alkyl bromides has been developed. This transformation avoids the use of stoichiometric organometallic reagents and introduces alkyl groups regio‐ and stereoselectively into the products. This method provides a platform for the synthesis of carbo‐ and heterocycles that are widely found in many natural products and biologically active molecules.
Enhanced Interfacial Conduction in Low‐Cost NaAlCl4 Composite Solid Electrolyte for Solid‐State Sodium Batteries
Authors: Ruoff Erick , Kmiec Steven , Manthiram Arumugam 
Published: June 2024

AbstractAll‐solid‐state sodium batteries offer the advantage of both sustainability and safety. Solid‐state electrolytes play a key role, and an oxygen‐incorporated NaAlCl4 composite electrolyte is presented with a high ambient‐temperature ionic conductivity of > 0.1 mS cm−1. The electrolyte synthesized with a mechanochemical reaction consists of in situ‐formed Al2O3 nanoparticles that provide enhanced conduction through an oxychloride phase at the interface. Magic angle spinning nuclear magnetic resonance spectroscopy confirms the formation of Al2O3 and the oxychloride phases at the interface and sheds insights into the origin of the enhanced ionic conductivity of the composite electrolyte. Additionally, simply adding Al2O3 nanoparticles to NaAlCl4 before mechanochemical synthesis is investigated, and a relationship between Al2O3 surface area and composite electrolyte ionic conductivity is identified. All‐solid‐state sodium batteries assembled with the composite electrolyte demonstrate a high specific capacity of 124 mA h g−1, clearly outperforming the baseline NaAlCl4 electrolyte. Furthermore, X‐ray photoelectron spectroscopy is utilized to understand the origin of capacity fade and obtain insights into electrolyte decomposition products. This work provides a deeper understanding of methods for boosting the ion transport in a low‐cost halide solid electrolyte for practical viability of all‐solid‐state sodium batteries.