bluuebunny/crossref_metadata_2025_split huggingface dataset:
High-dose accelerated hypofractionated three-dimensional conformal radiotherapy (at 3 Gy/fraction) with concurrent vinorelbine and carboplatin chemotherapy in locally advanced non-small-cell lung cancer: a feasibility study
Authors: Liu Yue-E , Lin Qiang , Meng Fan-Jie , Chen Xue-Ji , Ren Xiao-Cang , Cao Bin , Wang Na , Zong Jie , Peng Yu , Ku Ya-Jun , Chen Yan 
Published: August 2013

Abstract

Background
Increasing the radiotherapy dose can result in improved local control for non-small-cell lung cancer (NSCLC) and can thereby improve survival. Accelerated hypofractionated radiotherapy can expose tumors to a high dose of radiation in a short period of time, but the optimal treatment regimen remains unclear. The purpose of this study was to evaluate the feasibility of utilizing high-dose accelerated hypofractionated three-dimensional conformal radiotherapy (at 3 Gy/fraction) with concurrent vinorelbine (NVB) and carboplatin (CBP) chemotherapy for the treatment of local advanced NSCLC.

Methods
Untreated patients with unresectable stage IIIA/IIIB NSCLC or patients with a recurrence of NSCLC received accelerated hypofractionated three-dimensional conformal radiotherapy. The total dose was greater than or equal to 60 Gy. The accelerated hypofractionated radiotherapy was conducted once daily at 3 Gy/fraction with 5 fractions per week, and the radiotherapy was completed in 5 weeks. In addition to radiotherapy, the patients also received at least 1 cycle of a concurrent two-drug chemotherapy regimen of NVB and CBP.

Results
A total of 26 patients (19 previously untreated cases and 7 cases of recurrent disease) received 60Gy-75Gy radiotherapy with concurrent chemotherapy. All of the patients underwent evaluations for toxicity and preliminary therapeutic efficacy. There were no treatment-related deaths within the entire patient group. The major acute adverse reactions were radiation esophagitis (88.5%) and radiation pneumonitis (42.3%). The percentages of grade III acute radiation esophagitis and grade III radiation pneumonitis were 15.4% and 7.7%, respectively. Hematological toxicities were common and did not significantly affect the implementation of chemoradiotherapy after supportive treatment. Two patients received high dose of 75 Gy had grade III late esophageal toxicity, and none had grade IV and above. Grade III and above late lung toxicity did not occur.

Conclusion
High-dose accelerated hypofractionated three-dimensional conformal radiotherapy with a dose of 60 Gy or greater with concurrent NVB and CBP chemotherapy might be feasible. However esophagus toxicity needs special attention. A phase I trial is recommended to obtain the maximum tolerated radiation dose of accelerated hypofractionated radiotherapy with concurrent chemotherapy.
Chronic overload of SEPT4, a parkin substrate that aggregates in Parkinson’s disease, causes behavioral alterations but not neurodegeneration in mice
Authors: Ageta-Ishihara Natsumi , Yamakado Hodaka , Morita Takao , Hattori Satoko , Takao Keizo , Miyakawa Tsuyoshi , Takahashi Ryosuke , Kinoshita Makoto 
Published: August 2013

Abstract

Background
In autosomal recessive early-onset Parkinsonism (PARK2), the pathogenetic process from the loss of function of a ubiquitin ligase parkin to the death of dopamine neurons remains unclear. A dominant hypothesis attributes the neurotoxicity to accumulated substrates that are exempt from parkin-mediated degradation. Parkin substrates include two septins; SEPT4/CDCrel-2 which coaggregates with α-synuclein as Lewy bodies in Parkinson’s disease, and its closest homolog SEPT5/CDCrel-1/PNUTL1 whose overload with viral vector can rapidly eliminate dopamine neurons in rats. However, chronic effects of pan-neural overload of septins have never been examined in mammals. To address this, we established a line of transgenic mice that express the largest gene product SEPT454kDa via the prion promoter in the entire brain.

Results
Histological examination and biochemical quantification of SEPT4-associated proteins including α-synuclein and the dopamine transporter in the nigrostriatal dopamine neurons found no significant difference between Sept4
Tg/+ and wild-type littermates. Thus, the hypothetical pathogenicity by the chronic overload of SEPT4 alone, if any, is insufficient to trigger neurodegenerative process in the mouse brain. Intriguingly, however, a systematic battery of behavioral tests revealed unexpected abnormalities in Sept4
Tg/+ mice that include consistent attenuation of voluntary activities in distinct behavioral paradigms and altered social behaviors.

Conclusions
Together, these data indicate that septin dysregulations commonly found in postmortem human brains with Parkinson’s disease, schizophrenia and bipolar disorders may be responsible for a subset of behavioral abnormalities in the patients.
Demographics and outcomes of critically ill patients transferred from other hospitals to a tertiary care academic referral center in Saudi Arabia
Authors: Rishu Asgar H , Aldawood Abdulaziz S , Haddad Samir H , Tamim Hani M , Al-Dorzi Hasan M , Al-Jabbary Ahmed , Al-Shimemeri Abdullah , Sohail Muhammad R , Arabi Yaseen M 
Published: August 2013

Abstract

Background
The objective of this study was to examine the outcomes of critically ill patients who were transferred from other hospitals to a tertiary care center in Saudi Arabia as a quality improvement project.

Methods
This was a retrospective study of adult patients admitted to the medical-surgical intensive care unit (ICU) of a tertiary care hospital. Patients were divided according to the source of referral into three groups: transfers from other hospitals, and direct admissions from emergency department (ED) and from hospital wards. Standardized mortality ratio (SMR) was calculated. Multivariate analysis was performed to determine the independent predictors of mortality.

Results
Of the 7,654 patients admitted to the ICU, 611 patients (8%) were transferred from other hospitals, 2,703 (35.3%) were direct admissions from ED and 4,340 (56.7%) from hospital wards. Hospital mortality for patients transferred from other hospitals was not significantly different from those who were directly admitted from ED (35% vs. 33.1%, p = 0.37) but was lower than those who were directly admitted from hospital wards (35% vs. 51.2%, p < 0.0001). SMRs did not differ significantly across the three groups.

Conclusions
Critically ill patients who were transferred from other hospitals constituted 8% of all ICU admissions. Mortality of these patients was similar to patients with direct admission from the ED and lower than that of patients with direct admission from hospital wards. However, risk-adjusted mortality was not different from the other two groups.
Latin as an SDOV Language: The Evidence from Cicero
Authors: Eleric Charles 
Published: August 2013

AbstractBoth statistical and non-statistical analysis supports a claim that the Latin of Cicero is SDOV. Of 24 bitransitive strings from a representative sample, 21 show either the SDOV order or its common alternate SODV, or are principled departures from these orders, generally from SDOV. SDOV is the rule in clauses that are (1) discourse neutral, that (2) present special discourse challanges either because they involve gapped constituents or are expecially long, or that (3) have verbs of transfer that are lexically marked, e.g.
Zur Beziehung zwischen Kasus, Diathese und Referenz
Authors: Calboli Gualtiero 
Published: August 2013

RésuméOn part de la constatation qu'en latin l'emploi du r6flexif anaphorique (se,(1) Κλέωι/j ούκ εφη αύτός; αλλ' εκείνοι^ [sc. Νικίοα/] στρατηγεί/ (Th.4,28)S'il emploie l'anaphore, alors l'anaphore est ä l'accusatif:(2) Κροίσος έι/όμισε έωυτόι/j eu>ai ά/θρώπωι/ άπάι/των όλβιώτατο^ (Her.1,34).Comme le ddmonstre la phrase (1) le pronom peut se rdferer au sujet de la principale seulement s'il est au nominatif, s'il est ä l'accusatif, la r6f6rence du pronom est k un autre terme, comme il arrive avec έκεΐι/οι/ dans la phrase (1). Cela ddmontre, en s'accordant parfaitfement avec les logiciens et la thöorie du Binding de Chomsky, que l'accusatif dans la construction grecque et latine du Acl (Accusativus cum Infinitivo) ddnote une position transparente de laquelle vient exportd le terme en accusatif. Alors le cas accusatif dans la construction Acl indique simplement la position transparente qui va disparaitre lorsque l'on emploie le nominatif (Ncl) comme il arrive dans les phrases opaques oü l'on trouve l'INFLection:(3) Pierre; pensait qu' ilj avait raison.
Latin syllable structure in typological perspective
Authors: Lehmann Christian 
Published: August 2013

SummaryThree parameters are considered in the typology of Latin syllable structure: 1) phonotaxis of syllable structure; 2) correspondence of syllable structure with morpheme structure; 3) syllable structure processes. With respect to these parameters, Latin may be characterized as follows: 1) Latin allows moderate complexity of the onset, which, during its history, gets further reduced. Similarly, complexity of the nucleus is mostly reduced to a single short vowel. Latin allows relatively complex rhymes, which, however, get reduced in the language history; 2) Latin (as well as Romance languages) goes relatively far in blurring morphological boundaries, even left stem boundaries and, thus, word boundaries, by 'liaison'; 3. Latin phonology is relatively faithful to lexical representations. However, syllable structure is simplified, at the expense of the phonological manifestation of grammatical boundaries.
Les procédés de création lexicale mis en oeuvre par Lucrèce
Authors: Kircher-Durand Chantai 
Published: August 2013

SummaryThe hapax legomena substantives and adjectives created with a suffixal derivation by Lucretius are generally shaped according to the established derivational rules. From a cognitive point of view, these words corroborate that the two main activities of the human brain worked out in the natural languages are selection and association. Some less expected words allow us to point out an important parameter of the lexical creation : the pertinent features are set in a hierarchical frame. The remaining question is to know whether this hierarchy is inscribed in the system of each language or depends, entirely or partly, on the free speaker's choice.
Subordination seconde du relatif. Contraintes d'emploi.
Authors: Bortolussi Bernard 
Published: August 2013

SummaryThe aim of this paper is to complete Maurel's (1989) analysis on the so-called Relative Verschränkung of the German grammars. I examine the differences between two types : a) relative clauses containing a bridge-verb introducing an Acl, an wz-clause or an indirect question b) relative clauses containing a second relative clause or another subordinate clause. I take into account the frequency of these two types, the constraints on the form and the position of the subordinate clause within the relative clause.
Inserción sintáctica y Función Semántica en construcciones de Dativos no 'posesivos' + sum
Authors: Cabrillana Concepción 
Published: August 2013

SummaryThe paper surveys a characterization of diverse constructions of Ju/n+Dative from different linguistic levels (Semantic, Syntactic and Pragmatic). Two fundamental questions are particularly dealt with: the syntactic insertion in the hierarchical structure of the clause and the possible SF of the Datives examined. The proposed solutions take into account: (i) the graduality affecting the presence of different Arguments in nuclear predication and (ii) the procedure of prototypicity in the SF suggested, especially in the case of Recipient/Beneficiary.
Relative Clauses in Juridical Latin
Authors: Reggio Grazia 
Published: August 2013

SununaryRelative clauses in Juridical Latin are strictly connected with the succession of subjunctive and indicative mood and with the use of demonstrative and determinative pronouns. Regarding the first point, we observed that the Opposition between indicative and subjunctive mood often expresses the Opposition between factual and non-factual utterances. Subjunctive mood is also more frequent in the second part of the
Aspectos sintácticos, semánticos y pragmáticos de la deliberación-decisión en latin
Authors: Sánchez Manzano M. Asunción 
Published: August 2013

SummaryThe various levels of description to be discussed in the present paper are related to the socially relevant contexts depicted in our literary corpus. The scope of this matter is knowledge of use, which does not seem to be restricted by etymological relationships. From a glance at the quotations written, we are already familiar with the connection between deliberation and decision, despite their own characteristics. The existence of a large number of terms suggests that words rather than phrases are the units of sense. Nevertheless, the syntactic frame is no longer a mere option: it has become its structuring principle. Particularly relevant to it would be the relation assertive/report, that breaks up into two kinds of decisive (i. e. determination to act) expressions. Some of them are related to dare iudicium, but most can be seen as linguistic devices, enabling discourse organization. It should be stressed that these approaches appear to complement each other fruitfully, thus providing a better- defined (and linguistically based) description.
Mètre et syntaxe dans la pratique de trois poètes latins : Catulle, Virgile et Horace
Authors: Pumelle Gérald 
Published: August 2013

SummaryThis paper presents a method for measuring links between metre and syntax in the way three poets (Catullus, Horatius and Virgil) compose their hexameters. Based on the lemmatized files of LaSLa (Liēge) and on Tesniere’s dependency syntax, it aims to observe phenomena like (non-)coincidence of end of syntagm and end of verse line, syntactical consistency of the hexameter and so on. The test objects are: the place where sentences begin and end, syntactical connexions, syntagms exceeding the length of the line. It shows that poets like Catullus and Horatius don’t behave in the same way, and that the latter avoids less than the former this non-coincidence of meter and syntax: this is connected with a more “prosaic” nature of the writing of the Sermones.
Sur la différence de niveau de langue entre Piaute et Tirence
Authors: Smith Gerard 
Published: August 2013

SummaryOn the subject of Plautus’s and Terence’s registers, dependent questions enable to draw a worthwhile comparison. For the most part, the subordinating terms as adverbs, pronouns, adjectives and particles are the very same in both authors. Most of the verbs governing the subordinate clauses are common between them. But the main point concerns the mood of the dependent verb : Plautus and Terence use equally indicative and subjunctive so that the difference between them is hardly noticeable.
Inferring semantic maps
Authors: Regier Terry , Khetarpal Naveen , Majid Asifa 
Published: August 2013

Abstract
Semantic maps are a means of representing universal structure underlying semantic variation. However, no algorithm has existed for inferring a graph-based semantic map from cross-language data. Here, we note that this open problem is formally identical to the known problem of inferring a social network from disease outbreaks. From this identity it follows that semantic map inference is computationally intractable, but that an efficient approximation algorithm for it exists. We demonstrate that this algorithm produces sensible semantic maps from two existing bodies of data. We conclude that universal semantic graph structure can be automatically approximated from cross-language semantic data.
Association of Biocompatible Peritoneal Dialysis Solutions with Peritonitis Risk, Treatment, and Outcomes
Authors: Cho Yeoungjee , Badve Sunil V. , Hawley Carmel M. , McDonald Stephen P. , Brown Fiona G. , Boudville Neil , Bannister Kym M. , Clayton Philip A. , Johnson David W. 
Published: August 2013

Summary

Background and objectives
The effect of biocompatible peritoneal dialysis (PD) solutions on PD-related peritonitis is unclear. This study sought to evaluate the relationship between use of biocompatible solutions and the probability of occurrence or clinical outcomes of peritonitis.

Design, setting, participants, & measurements
The study included all incident Australian patients receiving PD between January 1, 2007, and December 31, 2010, using Australia and New Zealand Dialysis and Transplant Registry data. All multicompartment PD solutions of neutral pH were categorized as biocompatible solutions. The independent predictors of peritonitis and the use of biocompatible solutions were determined by multivariable, multilevel mixed-effects Poisson and logistic regression analysis, respectively. Sensitivity analyses, including propensity score matching, were performed.

Results
Use of biocompatible solutions gradually declined (from 7.5% in 2007 to 4.2% in 2010), with preferential use among smaller units and among younger patients without diabetes mellitus. Treatment with biocompatible solution was associated with significantly greater overall rate of peritonitis (0.67 versus 0.47 episode per patient-year; incidence rate ratio, 1.49; 95% confidence interval [CI], 1.19 to 1.89) and with shorter time to first peritonitis (hazard ratio [HR], 1.48; 95% CI, 1.17 to 1.87), a finding replicated in propensity score–matched cohorts (HR, 1.36; 95% CI, 1.09 to 1.71).

Conclusions
In an observational registry study, use of biocompatible PD solutions was associated with higher overall peritonitis rates and shorter time to first peritonitis. Further randomized studies adequately powered for a primary peritonitis outcome are warranted.
The freezing point of raw and heat treated sheep milk and its variation during lactation
Authors: Janštová Bohumíra , Navrátilová Pavlína , Králová Michaela , Vorlová Lenka 
Published: August 2013

The freezing point of milk is an important indicator of the adulteration of the milk with water, but heat treatment may also affect its value. The aim of this study was determine freezing point of raw and heat treated sheep milk and its variation during lactation. The freezing point was determined in 42 bulk tank raw sheep milk samples and 42 pasteurized milk samples collected during lactation of sheep at one ecofarm in Moravian Walachia (Valašsko in the Czech Republic). The freezing point was determined in accordance with the standard ČSN 57 0538 using a thermistor cryoscope. The average freezing point of raw milk was -0.617 ± 0.052 °C, with a range from -0.560 to -0.875 °C. The freezing point was lower in the first months of lactation and increased at the end of lactation. The freezing point correlated (r = 0.8967) with the content of total non-fat solids. The average freezing point of sheep milk pasteurized at 65 °C for 30 min was -0.614 ± 0.053 °C, with a range from -0.564 to -0.702 °C. The median of freezing point differences between raw and pasteurized milk was 0.004 °C. Our study extends data about physico-chemical properties of sheep milk and registers for the first time specific changes in the freezing point value of sheep milk by heating.
Image-guided chemoport insertion by interventional radiologists: A single-center experience on periprocedural complications
Authors: Yaacob Yazmin , Nguyen Dang V , Mohamed Zahiah , Ralib A Razali A , Zakaria Rozman , Muda Sobri 
Published: August 2013

Abstract
Purpose: To report our early experience in image-guided chemoport insertions by interventional radiologists. Materials and Methods: This was a cross-sectional study conducted in a tertiary center with 161 chemoport insertions done from June 2008 to June 2010. The chemoports were inserted either at the angiography suite or at the mobile operation theater unit. Ninety percent of the chemoports had right internal jugular vein (IJV) as the entry site. Other entry sites included the left IJV, subclavian veins and the inferior vena cava. Immediate and early complications were recorded. All insertions were performed under image guidance with the aid of ultrasound and fluoroscopy. Results: The technical success rate was 99.4%. In terms of immediate complications, there were only two cases of arterial puncture that resolved with local compression. No pneumothorax or air embolism was documented. Twenty-six early complications were recorded. The most common early complication was catheter blockage (12/161; 7.4%), followed by catheter-related infection (9/161; 5.6%). Other complications were catheter malposition, venous thrombosis and catheter dislodgement or leak. A total of 11 (6.8%) chemoports had to be removed within 30 days; most of them were due to infections that failed to respond to systemic antibiotic therapy. In terms of place of procedure, there were no significant differences in complication rates between the angiography suite and the mobile operation theater unit. Conclusion: Image-guided chemoport insertion by interventional radiologist gives low periprocedural complication rates. Using right IJV as the entry site, the image guidance gives good success rate with least complication.
Maternal FMR1 premutation allele expansion and contraction in fraternal twins
Authors: Alfaro Maria P. , Cohen Melinda , Vnencak‐Jones Cindy L. 
Published: August 2013

AbstractFragile X syndrome results from an expansion of the CGG trinucleotide repeat in the 5′ untranslated region of the Fragile X Mental Retardation 1 (FMR1) gene. Expansion of a maternal premutation allele is the mechanism by which a full mutation allele arises; contraction of a maternal premutation allele is rare. Here we report on both an expansion and contraction of a maternal FMR1 premutation allele in fraternal twins. The propositus was the product of a 29‐week gestation twin pregnancy and was referred for FMR1 testing due to developmental delay. A FMR1 full mutation with complete methylation was observed on Southern blot analysis. Evaluation of the maternal FMR1 gene by PCR revealed a normal and premutation allele with CGG repeat numbers of 30 and 93, respectively. Subsequent FMR1 testing on the twin sister of the propositus detected CGG repeat numbers of 30 and 54. The FMR1 CGG repeat number of the reproductive partner was 30. The FMR1 CGG repeat 30 allele in the twin sister was determined to be of paternal origin and the FMR1 allele with a CGG repeat number of 54 was of maternal origin. This observation is particularly interesting not only because of the concomitant donation of a FMR1 expanded and contracted premutation allele in a twin pregnancy but also because of the significant degree of contraction (39 repeats) of the maternal premutation allele. © 2013 Wiley Periodicals, Inc.