bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mirtazapine decreased cocaine-induced c-fos expression and dopamine release in rats
Authors: Barbosa-Méndez Susana , Salazar-Juárez Alberto 
Published: August 2024

IntroductionChronic cocaine exposure induces an increase in dopamine release and an increase in the expression of the Fos protein in the rat striatum. It has been suggested that both are necessary for the expression of cocaine-induced alterations in behavior and neural circuitry. Mirtazapine dosing attenuated the cocaine-induced psychomotor and reinforcer effects.MethodsThe study evaluates the effect of chronic dosing of mirtazapine on cocaine-induced extracellular dopamine levels and Fos protein expression in rats. Male Wistar rats received cocaine (10 mg/Kg; i.p.) during the induction and expression of locomotor sensitization. The mirtazapine (30 mg/Kg; MIR), was administered 30 minutes before cocaine during the cocaine withdrawal. After each treatment, the locomotor activity was recorded for 30 minutes. Animals were sacrificed after treatment administration. Dopamine levels were determined by high-performance liquid chromatographic (HPLC) in the ventral striatum, the prefrontal cortex (PFC), and the ventral tegmental area (VTA) in animals treated with mirtazapine and cocaine. The quantification of c-fos immunoreactive cells was carried out by stereology analysis. ResultsMirtazapine generated a decrease in cocaine-induced locomotor activity. In addition, mirtazapine decreased the amount of cocaine-induced dopamine and the number of cells immunoreactive to the Fos protein in the striatum, PFC, and VTA.DiscussionThese data suggest that mirtazapine could prevent the consolidation of changes in behavior and the cocaine-induced reorganization of neuronal circuits. It would explain the mirtazapine-induced effects on cocaine behavioral sensitization. Thus, these data together could support its possible use for the treatment of patients with cocaine use disorder.
Management of Arteriovenous Fistula After Successful Kidney Transplantation in Long-Term Follow-Up
Authors: Janeckova Jana , Bachleda Petr , Utikal Petr , Orsag Jirir 
Published: August 2024

Arteriovenous fistula (AVF) is the best method of vascular access for hemodialysis. This approach can lead to several complications, such as hyperkinetic heart failure due to a hyperfunctional AVF or dilatation of the feeding artery. These are late complications, especially in patients after a successful kidney transplantation. An observational study was performed focusing on patients more than 12 months after kidney transplantation. The AVF was evaluated by ultrasound and, if the outflow exceeded 1.5 L/min, an echocardiogram was performed. Surgical management was indicated if the cardiac index was higher than 3.9 L/min/m2 or upon finding a brachial artery aneurysm. A total of 208 post- kidney transplantation patients were examined over a 3-year period, of which 46 subjects (22.11%) had hyperfunctional AVF and 34 cases (16.34%) of feeding artery dilatation were determined. In total, 40 AVF flow reduction and 6 AVF ligation procedures were performed. The median AVF flow before and after the reduction was 2955 mL/min and 1060 mL/min, respectively. Primary patency after flow reduction was 88.3% at 12 months. Late AVF complications in patients following kidney transplantation are quite common. It is necessary to create a screening program to monitor AVFs in these patients.
Cell Wall Profiling of the Resurrection Plants Craterostigma plantagineum and Lindernia brevidens and Their Desiccation-Sensitive Relative, Lindernia subracemosa
Authors: Moore John P. , Kuhlman Brock , Hansen Jeanett , Gomez Leonardo , JØrgensen Bodil , Bartels Dorothea 
Published: August 2024

Vegetative desiccation tolerance has evolved within the genera Craterostigma and Lindernia. A centre of endemism and diversification for these plants appears to occur in ancient tropical montane rainforests of east Africa in Kenya and Tanzania. Lindernia subracemosa, a desiccation-sensitive relative of Craterostigma plantagineum, occurs in these rainforests and experiences adequate rainfall and thus does not require desiccation tolerance. However, sharing this inselberg habitat, another species, Lindernia brevidens, does retain vegetative desiccation tolerance and is also related to the resurrection plant C. plantagineum found in South Africa. Leaf material was collected from all three species at different stages of hydration: fully hydrated (ca. 90% relative water content), half-dry (ca. 45% relative water content) and fully desiccated (ca. 5% relative water content). Cell wall monosaccharide datasets were collected from all three species. Comprehensive microarray polymer profiling (CoMPP) was performed using ca. 27 plant cell-wall-specific antibodies and carbohydrate-binding module probes. Some differences in pectin, xyloglucan and extension epitopes were observed between the selected species. Overall, cell wall compositions were similar, suggesting that wall modifications in response to vegetative desiccation involve subtle cell wall remodelling that is not reflected by the compositional analysis and that the plants and their walls are constitutively protected against desiccation.
Entanglement and Generalized Berry Geometrical Phases in Quantum Gravity
Authors: Cirilo-Lombardo Diego J. , Sanchez Norma G. 
Published: August 2024

A new formalism is introduced that makes it possible to elucidate the physical and geometric content of quantum space–time. It is based on the Minimum Group Representation Principle (MGRP). Within this framework, new results for entanglement and geometrical/topological phases are found and implemented in cosmological and black hole space–times. Our main results here are as follows: (i) We find the Berry phases for inflation and for the cosmological perturbations and express them in terms of the observables, such as the spectral scalar and tensor indices, nS and nT, and the tensor-to-scalar ratio r. The Berry phase for de Sitter inflation is imaginary with the sign describing the exponential acceleration. (ii) The pure entangled states in the minimum group (metaplectic) Mp(n) representation for quantum de Sitter space–time and black holes are found. (iii) For entanglement, the relation between the Schmidt type representation and the physical states of the Mp(n) group is found: This is a new non-diagonal coherent state representation complementary to the known Sudarshan diagonal one. (iv) Mean value generators of Mp(2) are related to the adiabatic invariant and topological charge of the space–time, (matrix element of the transition −∞<t<∞). (v) The basic even and odd n-sectors of the Hilbert space are intrinsic to the quantum space–time and its discrete levels (in particular, continuum for n→∞), they do not require any extrinsic generation process such as the standard Schrodinger cat states, and are entangled. (vi) The gravity or cosmological domains on one side and another of the Planck scale are entangled. Examples: The quantum primordial trans-Planckian de Sitter vacuum and the classical late de Sitter vacuum today; the central quantum gravity region and the external classical gravity region of black holes. The classical and quantum dual gravity regions of the space–time are entangled. (vii) The general classical-quantum gravity duality is associated with the Metaplectic Mp(n) group symmetry which provides the complete full covering of the phase space and of the quantum space–time mapped from it.
Assessment of dental hard tissues and periodontium in children with hemophilia
Authors: Fedorova R. K. , Oreshaka O. V. , Fedorov K. P. , Rumyantsev A. A. 
Published: August 2024

Relevance. Children suffering from hemophilia primarily receive dental care when they present with acute tooth pain or exacerbation of an existing condition. Due to the rarity (orphan nature) of hereditary coagulopathies, dentists often lack the experience and knowledge to utilize modern methods of prevention and treatment for this patient category. Additionally, the lack of regular dental check-ups for children with hemophilia often leads to a high level of oral morbidity and a need for specific treatments, as indicated by literature data.Materials and methods. The primary methods used to assess oral health in children with hemophilia included detailed questioning, detection of carious lesions in dental hard tissues, assessment of oral hygiene, and the condition of periodontal tissues.Results. Among pediatric patients with hemophilia, poor oral hygiene was associated with a high prevalence of carious lesions (100%) and very high caries intensity values (8.8, ranging from 7 to 11). Additionally, there was a relatively high prevalence of gingival inflammation, accompanied by pronounced gingival bleeding. A direct correlation was identified between the level of oral hygiene and the degree of gingival bleeding in children aged 6-17 years with hemophilia. The deterioration of dental indicators corresponded to the severity of hemophilia, the primary disease in these children.Conclusion. The study demonstrated that pediatric patients with hemophilia, particularly those with moderate to severe forms, had significantly worse indicators of oral hygiene, dental hard tissues, and gingival health compared to generally healthy children. The results indicate the necessity for dental monitoring and rehabilitation for children with hemophilia to detect and effectively treat oral diseases at early stages.
Entrevista com a professora Juliane Corrêa sobre a história do Giz
Authors: Corrêa Juliane , Flores Maria José Batista Pinto , Campos Paulo Mariano Eulálio 
Published: August 2024

A professora Juliane Corrêa, da Faculdade de Educação (FaE) da Universidade Federal de Minas Gerais (UFMG), foi quem esteve à frente da implementação do Giz na UFMG, desde seu estabelecimento em 2008. Vinculado à Pró-Reitoria de Graduação da UFMG, o Giz é uma Diretoria de Inovação e Metodologias de Ensino, espaço no qual a professora Juliane atuou como diretora nos seis primeiros anos, construindo as condições materiais e pedagógicas de sua proposta no âmbito da UFMG. Posteriormente, tornou-se diretora da FaE (2014-2018). Considerando que no ano de 2018 o Giz completa 10 anos de experiência no cenário da UFMG e que a implementação desse espaço ins tucional se deu sob sua coordenação, a professora Juliane nos concedeu esta entrevista tratando dessa história.
A Extensão que queremos
Authors: De Oliveira Valter Vander 
Published: August 2024

Para entender melhor o que é a extensão temos que também conversar sobre que tipo de extensão queremos para o IFSC? Por consequência, estaremos, na realidade, discutindo que instituição queremos e como podemos chegar lá? Sem esquecer que a interação com a comunidade, com os estudantes, com os professores e técnico-administrativos é requisito fundamental para respondermos essas questões. Refletindo sobre esse tema, podemos afirmar que nossa história está repleta de conquistas e exemplos de muito sucesso. Formamos muitos estudantes e acredito que tenhamos impactado suas vidas e de muitas famílias. Digo isso por frequentemente ouvir relatos e elogios à nossa instituição. Mesmo assim, em alguns momentos, converso com pessoas que ainda não conhecem o IFSC e, pior, sentem-se despreparadas ou até desacreditadas de que este ambiente possa fazer parte de sua realidade.Quantas pessoas ainda olham para nossa instituição como algo inalcançável, um lugar que não lhes pertence? Quais ações estamos realizando para nos aproximar dessas pessoas?
PENGARUH PROFITABILITAS, LEVERAGE DAN KEBIJAKAN DIVIDEN TERHADAP HARGA SAHAM DI BURSA EFEK INDONESIA
Authors: Indriani Made , Harnida Muthia , Nurhayati Netty 
Published: August 2024

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh profitabilitas, leverage dan kebijakan dividen terhadap harga saham baik secara parsial dan simultan pada Perusahaan Makanan dan Minuman yang terdaftar di Bursa Efek Indonesia. Sampel yang digunakan dalam penelitian ini adalah 40 data perusahaan yang berasal dari 8 perusahaan makanan dan minuman yang terdaftar di Bursa Efek Indonesia untuk periode 2018 s/d 2022. Teknik analisis data yang digunakan adalah analisis regresi linier berganda. Data dianalisis dengan menggunakan SPSS IBM versi 26. Hasil penelitian membuktikan bahwa secara parsial profitabilitas (ROA) berpengaruh positif tidak signifikan terhadap harga saham perusahaan, leverage (DER) berpengaruh negatif signifikan terhadap harga saham dan kebijakan dividen (DPR) berpengaruh negatif signifikan terhadap harga saham perusahaan. Sedangkan secara simultan profitabilitas, leverage dan kebijakan dividen berpengaruh signifikan terhadap harga saham dengan pembagian proporsi pengaruh sebesar 45%.
Combined nefopam-fentanyl use in PCA for postoperative analgesia in spinal surgery patients: a randomized, controlled, single-blind trial
Authors: Le Xuan Duong , Nguyen Minh Ly , Nguyen Duy Thang , Do Thanh Hoa , Nguyen Hai Ghi 
Published: August 2024

Background & objective: The use of fentanyl to manage postoperative pain in spinal surgery patients is common, although there have been concerns about potential of drug abuse and dependence. We investigated the effects of the combined administration of nefopam and fentanyl through intravenous (IV) patient-controlled analgesia (PCA) on early postoperative pain and possible side effects in patients undergoing spinal surgeries.
Methodology: In this randomized, controlled study, 70 patients were allocated to receive either fentanyl 10 µg/mL (Group F) or fentanyl 10 µg/mL with nefopam 1.2 mg/mL (Group FN), with a total PCA volume of 100 mL per infusion bag. Patients received a background dose of 0.25 µg/kg/h and bolus dose of 0.5 mL SOS (fentanyl 5 µg). The lockout interval was set at 10 min and upper limit was set at 15 mL/4 h. The PCA parameters were set according to the body weight of each patient.
Results: The cumulative postoperative fentanyl consumptions after 48 h for Group F and Group NF were reported as 744.6 ± 94.2 µg and 631 ± 62.5 µg (P < 0.05) respectively. The average number of bolus doses requested by the patients in Group F and FN were 20.8 ± 11.0, and NF 11.4± 7.6). The A/D ratio of both groups for the bolus doses were 70%. Group NF consistently scored a lower VAS and VAS-D score during the 48-hour postoperative period. However, the VAS scores significantly differ statistically between groups at 1, 6, 9, and 12 hours. Within group differences, the VAS score differed significantly statistically during the 0-1, 1-2, and 2-3 hours for Group F, while 24-36 hours for Group NF.
Conclusion: The inclusion of nefopam in patient-controlled analgesia for spine surgery patients significantly reduced total use of fentanyl within the 48 hours postoperatively after the surgery. Patients receiving fentanyl with nefopam consistently had lower VAS scores at different time points.
Abbreviations: PCA - patient-controlled analgesia; VAS - Visual Analogue Scale
Keywords: postoperative pain, fentanyl, nefopam, patient-controlled analgesia
Citation: Le XD, Nguyen ML, Nguyen DT, Do TH, Nguyen HG. Combined nefopam-fentanyl use in PCA for postoperative analgesia in spinal surgery patients: a randomized, controlled, single-blind trial. Anaesth. pain intensive care 2024;28(4):687−691; DOI: 10.35975/apic.v28i4.2370
Received: January 06, 2024; Reviewed: April 14, 2024; Accepted: April 14, 2024
The effect of early neuromuscular electrical stimulation in intensive care unit-acquired weakness
Authors: Yustiawan Arief , Semedi Bambang Pujo , Arfianti Lydia , Hidayati Hanik Badriyah , Maulydia Maulydia , Edwar Pesta Parulian Maurid , Airlangga Prananda Surya , Santoso Kohar Hari , Andriana Meisy 
Published: August 2024

Background & objective: Intensive Care Unit-Acquired Weakness (ICU-AW) is a weakness found in critically ill patients, and this weakness can persist even after discharge from the Intensive Care Unit (ICU). Various rehabilitation medicine procedures have been shown to be effective in prevention as well as managing the established weakness in this cohort of the patients. We analyzed the effect of Neuromuscular Electrical Stimulation (NMES) therapy on the global muscle strength, quadriceps femoris muscle, and creatine kinase examination in patients known to have ICU-AW.
Methodology: The type of study used a pre-experimental one-group pre-posttest, and the study population consisted of 23 patients who experienced ICU-AW. Patients were given NMES therapy at the beginning of treatment in the ICU and then evaluated using the Medical Research Council Scale for Muscle Strength (MRC-SS), Manual Muscle Test (MMT), and creatine kinase levels.
Results: NMES therapy provides significant results on increasing muscle strength on the fifth day with MRC-SS 42.78 (24-60) and MMT 3.57 (2-5) (P < 0.001), as well as a significant decrease in creatine kinase levels given therapy at the beginning of ICU admission.
Conclusion: NMES therapy increases global muscle strength and quadriceps femoris muscle and decreases creatine kinase levels.
Abbreviations: ICU-AW - Intensive Care Unit-Acquired Weakness, NMES - Neuromuscular Electrical Stimulation, ICU - Intensive care unit, MRC-SS - Medical Research Council Scale for Muscle Strength, MMT - Manual Muscle Testing, CK-MM - Creatine kinase muscle specific
Key Words: Neuromuscular electrical stimulation; Intensive Care Unit-Acquired Weakness, Creatine kinase
Citation: Yustiawan A, Semedi BP, Arfianti L, Maulydia, Edwar PPM, Airlangga PS, Santoso KH, Andriana M. The effect of early neuromuscular electrical stimulation in intensive care unit-acquired weakness. Anaesth. pain intensive care 2024;28(4):706−711; DOI: 10.35975/apic.v28i4.2405
Received: March 04, 2024; Reviewed: April 29, 2024; Accepted: May 10, 2024
Evaluation of vascular endothelial growth factor and interleukin-1 receptor antagonists of synovial fluid cytokines in patients with anterior cruciate ligament injury, meniscal tear and cartilage damage
Authors: Abd Ali Ahmed J. , Alzaniily Ajile A. , AL-Ardi Iskandar 
Published: August 2024

Background & objective: Knee pain, related to osteoarthritis (OA) of the knees is a disease of middle to old age. The males are the predominant victims. It has been suggested that knee diseases may be related to inflammatory biomarkers such as vascular endothelial growth factor (VEGF-A) and interleukin-1 (IL-1Ra) receptor antagonists of synovial fluis cytokines. These biomarkers might provide diagnostic and prognostic information to the clinicians. We investigated the levels of VEGF-A and IL-1Ra in patients known to suffer from suffered from anterior cruciate ligament (ACL) injuries, meniscal tears, and cartilage damage.
Materials and methods: A total of 76 Iraqi participants were diagnosed to be suffering from anterior cruciate ligament (ACL) injuries, meniscal tears, and/or cartilage damage during the period from November 2022 to May 2023. They were admitted to the Al-Furat Al-Awsat Private Hospital in the Al-Qadisiyah Governorate, Iraq. The patients were divided into three groups according to the duration of the disease: Group I included patients with injuries for less than 6 months, Group II with 6-12 months and Group III had patients with injuries for more than one year. The enzyme-linked immunosorbent assay (ELISA) technique was used to detect inflammatory markers VEGF-A and and IL-1Ra. Data were summarized, and Microsoft Office Excel 2013 and GraphPad Prism 9.2.0 were used to present the statistical analysis.
Results: Patients in Group I showed a significantly elevated level of VEGF-A (372.2 ± 68.95 pg/mL) as compared to Group II (273.5 ± 53.47 pg/mL) and Group III (232.2 ± 28.22 pg/mL) (P < 0.0001). While the concentration of IL-1Ra declined in patients with Group III (162.1 ± 7.036 pg/mL), as compared with both Group II (173.1 ± 9.351 pg/mL) and Group I ( 200 ± 34.53 pg/mL) with significant differences (P < 0.0001).
Conclusion: The current study identified two synovial fluid biomarkers, vascular endothelial growth factor (VEGF-A) and interleukin-1 (IL-1), receptor antagonists of synovial fluis cytokines, whose concentrations after anterior cruciate ligament injury differ depending on the duration of the injury.
Abbreviations: ACL - anterior cruciate ligament; OA - osteoarthritis; IL-1Ra - interleukin-1 receptor antagonists; VEGF-A - vascular endothelial growth factor
Keywords: Vascular Endothelial Growth Factor; interleukin-1 Receptor Antagonists; Anterior Cruciate Ligament
Citation: Abd Ali AJ, Alzaniily AA, AL-Ardi I. Evaluation of vascular endothelial growth factor and interleukin-1 receptor antagonists of synovial fluid cytokines in patients with anterior cruciate ligament injury, meniscal tear and cartilage damage. Anaesth. pain intensive care 2024;28(4):616−619; DOI: 10.35975/apic.v28i4.2501
Received: December 16, 2023; Reviewed: April 13, 2024; Accepted: April 24, 2024
Dexmedetomidine versus labetalol for induced hypotension during functional endoscopic sinus surgery: a randomized, double-blind study
Authors: Gupta Savita , Yadav Isha , Saxena Anupriya , Bagla Rahul Kumar , Nazir Nazia 
Published: August 2024

Background & Objective: Functional endoscopic sinus surgery (FESS) is a surgical procedure for treating sinus diseases. Bleeding is a common concern during FESS, so maintaining hemodynamic stability and ensuring quality surgical field visibility is crucial for achieving the best outcomes. The present study compared the time taken to achieve target mean arterial pressure (MAP) when using dexmedetomidine or labetalol during FESS and assessed the quality of the surgical field to establish the better choice of the two.
Methodology: The study was conducted as a prospective, randomized, double-blinded clinical study. Sixty patients classified as American Society of Anesthesiologists grade I or II, undergoing FESS under general anesthesia, were divided into two groups, each with 30 patients. Group D patients received dexmedetomidine and Group L received labetalol. The study aimed to maintain the mean arterial pressure (MAP) between 60-70 mmHg. The operative field visibility was assessed using the Fromme and Boezaart scoring system. Emergence time and postoperative first analgesic request time were also recorded.
Results: The time taken to achieve target MAP (60-70 mmHg) was less in Group D (15.1 ± 0.2 min) than in Group L (18.2 ± 0.5 min), and it was statistically significant (P < 0.05). Although insignificant, lower MAP were observed in the Group D than Group L. A significantly lower heart rate was observed at defined intervals in Group D than in Group L. The visibility of the surgical field in both groups has comparable results. The first analgesic request time was considerably longer in Group D (52.2 ± 1.9) compared to Group L (10.2 ± 2.1) (P < 0.05).
Conclusion: Dexmedetomidine provided better hemodynamic stability and operative field visibility than Labetalol during FESS.
Abbreviations: FESS - Functional endoscopic sinus surgery; MAP - Mean arterial pressure; EtCO2 - end-tidal carbon dioxide
Keywords: Dexmedetomidine; Labetalol; Controlled Hypotension; Mean Arterial Pressure
Citation: Gupta S, Yadav I, Saxena A, Bagla RK, Nazir N. Dexmedetomidine versus labetalol for induced hypotension during functional endoscopic sinus surgery: a randomized, double-blind study. Anaesth. pain intensive care 2024;28(4):652−657; DOI: 10.35975/apic.v28i4.2507
Received: May 19, 2024; Reviewed: June 08, 2024; Accepted: June 08, 2024