bluuebunny/crossref_metadata_2025_split huggingface dataset:
Transseptal approach versus retrograde aortic approach in mapping and ablation of ventricular arrhythmias from anterolateral papillary muscles
Authors: Jiang Chen‐Xi , Li Shao‐Long , Li Meng‐Meng , Tang Ri‐Bo , Sang Cai‐Hua , Wang Wei , Dong Jian‐Zeng , Long De‐Yong , Zei Paul C. , Ma Chang‐Sheng 
Published: July 2024

AbstractIntroductionThe anterior and lateral position of the anterolateral papillary muscle (ALPM) has found to be reached with better catheter stability and less mechanical bumping via the transseptal (TS) compared to the retrograde aortic (RA) approach. The aim of this study is to compare the TS and RA approaches on mapping and ablation of ventricular arrhythmias (VAs) arising from ALPMs.MethodsThirty‐two patients with ALPM‐VAs undergoing mapping and ablation via the TS approach were included and compared with 31 patients via the RA approach within the same period. Acute success was compared, as well as other outcomes including misinterpreted mapping results due to bumping, radiofrequency (RF) attempts, procedural time and success rate at 12‐month follow‐up.ResultsAcute success was achieved in more cases in the TS group (96.4% vs. 72.0%, p = .020). During activation mapping, bump‐provoked premature ventricular complexes (PVCs) misinterpreted as clinical PVCs were more common in the RA group (30.0% vs. 58.3%, p = .036), leading to more RF attempts (3.5 ± 2.7 vs. 7.2 ± 6.8, p = .006). Suppression of VAs were finally achieved in the unsuccessful cases by changing to the alternative approach, but the procedural time was significantly less in the TS group (90.0 ± 33.0 vs. 113.7 ± 41.1 min, p = .027) with less need to change the approach, although follow‐up success rates were similar (75.0% vs. 71.0%, p = .718).ConclusionA TS rather than RA approach as the initial approach appears to facilitate mapping and ablation of ALPM‐VAs, specifically by decreasing the possibility of misleading mapping results caused by bump‐provoked PVC, and increase the acute success rate thereby.
Sex differences in long‐term outcomes following transvenous lead extraction
Authors: Arabia Gianmarco , Aboelhassan Mohamed , Calvi Emiliano , Cerini Manuel , Bellicini Maria Giulia , Bontempi Luca , Giacopelli Daniele , Nawar Amr , Raweh Abdallah , Abbas Mohamed Magdy M. , Curnis Antonio 
Published: July 2024

AbstractIntroductionTransvenous lead extraction (TLE) is generally considered a safe procedure, albeit not without risks. While gender‐based disparities have been noted in short‐term outcomes following TLE, a notable gap exists in understanding the long‐term consequences of this procedure. The objective of this analysis was to investigate sex differences in both acute and long‐term outcomes among patients who underwent TLE at a tertiary referral center.MethodsIn this retrospective cohort study, consecutive patients who underwent TLE between January 2014 and January 2016 were enrolled. The primary outcome comprised a composite of all‐cause mortality and need for repeated TLE procedures. Secondary outcomes included fluoroscopy time, lead extraction techniques, success rates, and major and minor complications. Results were compared between female and male cohorts.ResultsThe study population comprised 191 patients (median age, 70 years), 29 (15.2%) being women and 162 men (84.8%). Study groups had similar baseline characteristics. Complete procedural success was achieved in 189 out of 191 patients (99.0%), with no significant difference observed between the two groups (p = .17). No major complications were reported in the total cohort. However, there was a significantly higher incidence of minor complications in women compared to men (17.2% vs. 2.5%, p < .01). Following a median follow‐up of 6.5 years, the incidence of the primary composite outcome occurred similarly between the study groups (log‐rank p = .68).ConclusionWomen who underwent TLE exhibited a significantly higher incidence of minor acute intra‐ and peri‐procedural complications than men. However, no differences in long‐term outcomes between genders were observed.
Impact of frailty in hospitalized patients undergoing catheter ablation for atrial fibrillation
Authors: Ali Shafaqat , Kumar Manoj , Khlidj Yehya , Hendricks Emily , Farooq Faryal , Alruwaili Waleed , Keisham Bijeta , Duhan Sanchit , Gonuguntla Karthik , Sattar Yasar , Shaik Ayesha , Brar Vijaywant , Asad Zain Ul Abideen , Sorajja Dan , Dominic Paari , Helmy Tarek 
Published: July 2024

AbstractBackgroundCatheter Ablation (CA) is an effective treatment for atrial fibrillation (AF). However, frail elderly patients have been understudied due to their exclusion from landmark trials.ObjectivesOur study aims to evaluate outcomes in this population.MethodsThe national readmission database (2016–2020) was queried, and frailty categories were defined based on hospital risk frailty scores ≦5 as low while >5 as intermediate/high frailty (IHF). We used multivariate regression and propensity‐matched analysis to compare outcomes in patients undergoing CA for atrial fibrillation based on frailty index.ResultsAmong 55 936 CAs for AF, 33,248 patients had low frailty, while 22 688 had intermediate/high frailty (IHF). After propensity matching (N 12 448), IHF patients were found to have higher adverse events, including mortality (3% vs. 0.3%, p < .001), stroke (1.9% vs. 0.2%, p < .001), acute heart failure (53.8% vs. 42.2%, p < .001), AKI (42.5% vs. 6.8%, p < .001), pericardial complications (2.8 vs. 1.6%, p < .001), respiratory complications (27.8 vs. 7.2%, p < .001), major adverse cardiovascular events (21.2 vs. 9.4%, p < .001) and net adverse events (76.7 vs. 55%, p < .001). IHF patients had higher readmissions at 30 (15.5 vs. 12.6%, p < .001), 90 (31.9 vs. 25.1%, p < .001), and 180‐day (41 vs. 34.7%, p < .001) intervals. A higher median length of stay (LOS) (7 vs. 3 days, p < .001) and cost ($44 287 vs. $27 517, p < .001) at index admission and subsequent readmissions were also observed (p < .001).ConclusionIntermediate/high frailty patients undergoing catheter ablation had worse clinical outcomes, higher healthcare burden, and readmission rates. LOS has decreased in both groups from 2016 to 2020; however, total cost has increased.
Glycemic metrics in Japanese isCGM users – Analysis by diabetes type and therapy
Authors: Ogawa Wataru , Urakami Tatsuhiko , Kadowaki Takashi , Kao Kalvin , Brandner Laura , Shimizu Kenichiro , Dunn Timothy C. 
Published: July 2024

ABSTRACTAims/IntroductionThe FreeStyle Libre (FSL) intermittently scanned continuous glucose monitoring (isCGM) system continually measures interstitial glucose levels and provides the data to users in numerical and graphical formats that guide users in their daily diabetes self‐management. Although numerous studies have demonstrated the glycemic benefits of FSL in pediatric and adult populations, few studies have characterized FSL use specifically by Japanese adults with type 1 or 2 diabetes. We utilized established CGM metrics to assess glycemic control in a large cohort of Japanese adults with type 1 and 2 diabetes.Materials and MethodsA total of 3,463 anonymized FSL users provided categorization into one of four therapy groups of interest: type 1 diabetes (n = 1,768), type 2 diabetes‐multiple daily injections (MDI) (n = 612), type 2 diabetes‐basal (BOI) (n = 343), and type 2 diabetes‐non‐insulin (NIT) (n = 740). Established CGM metrics were used to assess glycemic control.ResultsAll study groups showed relatively good glycemic control. Type 1 diabetes users showed the highest glucose variability (SD, 61 mg/dL; and %CV, 40%), above the established target level (%CV ≤ 36%). type 2 diabetes‐MDI and type 2 diabetes‐BOI users had similar levels of glucose variability (both within target). Type 2 diabetes‐NIT users had the highest mean % time in range (TIR) (84.3%) and largest percentage of users that met the target of %TIR > 70% (87.4%). In contrast, type 1 diabetes users had the lowest mean %TIR (62.6%) and the lowest percentage meeting the established %TIR target (30.5%).ConclusionsBy utilizing CGM devices in daily diabetes care, both healthcare professionals and patients can monitor glycemic excursions and gain insights into their historical glucose control patterns.
The effect of different materials and cavity designs on fracture resistance of ceramic partial coverage
Authors: Attia Mahmoud , Fahmy Nadia , Shaker Atef , Salah Tarek 
Published: July 2024

AbstractBackgroundTwo intra‐coronal preparation designs with varying extensions of cuspal coverage can perform differently regarding their fracture resistance against introral forces.MethodsTwo materials (IPS e‐max CAD [EX], VITA ENAMIC [EN]), and two different preparation designs (EX‐D1), (EX‐D2), (EN‐D1), and (EN‐D2) were investigated to compare their fracture resistance. A total of 40 (n = 40) caries free human mandibular molars were used. All the prepared samples were scanned using CEREC Omnicam scanner and the preparations were checked by the software for any sharpness and undercuts before restoration designing and fabrication. All restorations were milled using Cerec MCXL 4.4 milling machine. Duo‐Link resin cement was used for cementation. After thermocycling and chewing simulation, all samples were loaded in the Universal testing machine in order to evaluate fracture resistance of all samples.ResultsFracture resistance testing revealed that e‐max CAD (2134 N) showed statistically significantly higher mean fracture resistance values than Vita Enamic (1728 N). On the other hand, there was no statistically significant difference between mean fracture resistances between the two tested designs.ConclusionsWithin the confines of this investigation, it can be said that although preparation design had no appreciable impact on fracture resistance, the CAD/CAM ceramic material utilized did.Clinical SignificanceWhen restoring compound cavitties indirectly; a conservative defect oriented approach should be used. Glass Ceramic are prefered as restorative material.
Nursing Home Compare star ratings before versus after a change in nursing home ownership
Authors: Ryskina Kira L. , Tu Emily , Liang Junning , Kim Seiyoun , Werner Rachel M. 
Published: July 2024

AbstractBackgroundEfforts to increase transparency and accountability of nursing homes, and thus improve quality, now include information about changes in nursing home ownership. However, little is known about how change in ownership affects nursing home quality.MethodsWe conducted a retrospective cohort study of 15,471 U.S. nursing homes between January 2016 and December 2022, identifying all changes in ownership during that period. We used logistic regression to measure the association between nursing home characteristics and the odds of a change in ownership. A difference‐in‐differences model with multiple time periods was used to examine the impact of a change in ownership on the Medicare Nursing Home Compare 5‐star ratings.ResultsOne in five (23%) facilities changed ownership between 2016 and 2022. Nursing homes that were urban, for‐profit, part of a chain, located in the South, had >50 beds, lower occupancy, higher percentage of stays covered by Medicaid, higher percentage of residents with non‐white race, or a 1‐star (poor) rating were more likely to undergo a change in ownership. There was a small statistically significant decrease in 5‐star ratings after a change in ownership (−0.09 points on a 5‐point scale; 95% CI −0.13 to −0.04; p < 0.001), driven primarily by a decrease in staffing ratings (−0.19 points; 95% CI −0.24 to −0.14; p < 0.001), and health inspections ratings (−0.07 points; 95% CI −0.11 to −0.03; p = 0.001). This was mitigated by an increase in quality measure ratings (0.15 points; 95% CI 0.10–0.20; p < 0.001).ConclusionNursing Home Compare ratings decreased slightly after a change in facility ownership, driven by lower staffing and health inspection ratings and mitigated somewhat by higher quality measure ratings. These conflicting trends underscore the need for transparency around changes in facility ownership and a better understanding of consequences of changes in ownership that are salient to patients and families.
Human trapezius muscle development during the early fetal period
Authors: Iwasa Yui , Kanahashi Toru , Imai Hirohiko , Otani Hiroki , Yamada Shigehito , Takakuwa Tetsuya 
Published: July 2024

AbstractThis study aimed to observe human trapezius muscle (TpzM) development during early fetal period and apply diffusion tensor imaging (DTI) analysis to describe the muscle architecture that leads to physiological functions. Human embryonic and early fetal specimens were selected for this study. TpzM was first detected at Carnegie stage 20. The position of the TpzM changed with the formation of the scapula, clavicle, and vertebrae, which are its insertions and origins. DTI revealed the fiber orientation from each vertebral level to dissect each muscle. Fiber orientation in the ventral view gradually changed from the cervical to thoracic vertebrae, except for the middle part at which the insertions changed, which was almost similar in all early fetal specimens. The TpzM volume increased from C1 to C7 in the upper part, reached local maxima at C6 and C7 in the middle, and then decreased. These muscles can be categorized into three parts according to their insertions and presented with the features of each part. The fiber orientation and distribution of the three parts at the vertebral level were almost constant during the early fetal period. The border between the upper and middle parts was mainly located around the C6 and C7 vertebral levels, whereas the middle and lower parts were between the Th1 and Th2 vertebral levels. A three‐dimensional change in the fiber orientation in the upper part of the TpzM according to the vertebral level was noticeable. Our data will help to elucidate the developmental processes of TpzM.
Speaking Up to the Boss: The Effects of Top Management Team Members' Felt Trust and Perceived CEO Trustworthiness on Voice Behaviour in Family Firms
Authors: Faherty Catherine M. , Clinton Eric 
Published: July 2024

AbstractDespite the important role of top management team (TMT) voice, the innate risks and vulnerabilities involved often dissuade TMT members from openly expressing their views to the chief executive officer (CEO). This is especially the case in family firms, where the CEO is often a family member and familial ties regularly take priority over ties with individuals from outside the family (i.e., non‐family members). In this article, we focus on the role of trust as a potential enabler of TMT voice in family firms. Primary matched triadic data from CEOs (n = 79) and family and non‐family TMT members (n = 158) in 79 family firms demonstrate that trust perceptions (feeling trusted by the CEO and perceptions of CEO trustworthiness) have a positive effect on TMT voice behaviour and perceived job performance. Interestingly, this positive effect is significant only for non‐family members, suggesting trust perceptions are more imperative for non‐family TMT members when it comes to speaking up to the boss. A main implication for scholarship at the interface of trust and family business is that our nuanced, and in some instances counterintuitive, findings suggest traditional theories and approaches to studying trust may not apply to family firms. We also discuss practical implications of our findings.
Unintended distortion of regulating water use: Evidence from China
Authors: Zhong Hua 
Published: July 2024

AbstractThe Chinese government has been using water efficiency targets to manage commercial, institutional, and industrial water use across the country. This paper argues that water efficiency targets may influence provincial administrators’ preferences in tightening water regulation in cities with higher water use while disproportionately overregulating water use in productive cities to satisfy their efficiency goals. I develop a city‐level production model with water regulation preferences and show that the unintended distortion of water regulation in response to water efficiency targets leads to efficiency loss of resource allocation and further reshapes regional output across cities, especially for productive cities. Using a sample of city‐level water data from 2006 to 2016 in China, this paper empirically investigates the impact of the Three Red Lines (TRL) policy on provincial administrators’ preferences in water use regulation. The results indicate that the elasticity of water regulation in response to the policy is approximately −0.64 to −0.8 and has resulted in tighter water regulations for cities with higher economic outputs. Quantitatively, eliminating water distortions would reshape water use across cities and increase the aggregate output of an entire province by up to 0.069%. The results imply that possible consequences of the political consideration of provincial administrators in satisfying water efficiency targets include inefficiency and inequality in water allocation.
Tolerance of juvenile lumpfish (Cyclopterus Lumpus) to high rearing densities
Authors: Spada Nathaniel N. , Fairchild Elizabeth A. , Trushenski Jesse T. 
Published: July 2024

AbstractLumpfish (Cyclopterus lumpus) are raised as cleaner fish for controlling sea lice. Intensive rearing is complicated by fin nipping that occurs between juvenile conspecifics. Lumpfish density‐dependent interactions are not well understood; therefore, the effects of rearing density for different fish size classes warranted evaluation. Two size classes (2‐ and 13‐g) of juvenile lumpfish were stocked at four different rearing densities (40, 60, 70, and 90 g/L) with growth, survival, and fish aggression assessed over 8 weeks. Mean weight gain and specific growth rates ranged from 170% to 307% and 1.77% to 2.50%, respectively, depending on density treatments, for the 2‐g fish, and from 286% to 471% and 2.42% to 3.10% for the 13‐g fish. Growth was negatively correlated with density, with faster growth linked to lower densities. No mortality occurred in any treatment and significant fish aggression only occurred among the larger lumpfish in the higher rearing densities. Based on these findings, growth of 2‐g lumpfish can be increased if reared at 40 g/L or slowed at 70 g/L without impacting aggression. For grow out of 13‐g fish to ~70 g with minimal aggression, a 40 g/L rearing density is recommended for faster growth and 60 g/L for slower growth.
Living in a predictable environment: Intraspecific variation in tadpole size and shape of the Sierra's treefrog
Authors: Bonino A. , Lescano J. , Goldberg J. , Quinzio S. I. 
Published: July 2024

AbstractWithin the breeding sites of anurans, factors at the microhabitat scale can exhibit variations over the years, resulting in temporal fluctuations within these sites. These fluctuations may lead to modifications in “normal larval development” and observable phenotypic changes. These developmental alterations appear to have evolved as shared strategies for achieving reproductive success and ensuring the survival of offspring. In a population of Boana cordobae inhabiting the Central Pampean Sierras (Córdoba, Argentina), the coexistence of pre‐ and prometamorphic tadpoles throughout the year, coupled with variations in size and shape within the same developmental stage, has led us to question about the duration of the larval period, variations in the timing of developmental events, and the possible existence of distinct larval morphs for this species. Utilizing data collected over four consecutive years from various locations, we described the development, growth, and larval morphology using both linear and geometric morphometrics during the pre‐ and prometamorphic stages. Our aim was to comprehend how anuran larvae in predictable environments synchronize the timing of their phenotypic transformations with external conditions. We identified two distinct cohorts: spring–summer and autumn–spring, each exhibiting distinct rates of growth and development until metamorphosis, resulting in size discrepancies. Moreover, the physical attributes of the breeding sites influenced the size of the tadpoles. However, the observed variation in shape was not related to the ontogenetic period, cohort, or developmental site. Ultimately, the observed variations had no impact on the morphology at metamorphosis. The comprehensive data gathered from our observations in B. cordobae yield valuable insights that contribute to a deeper comprehension of anuran larval development under natural conditions where changes are predictable and follow a regular pattern throughout the year, ultimately maximizing reproductive success.
Impaired HBsAg release and antiproliferative/antioxidant cell regulation by HBeAg‐negative patient isolates reflects an evolutionary process
Authors: Basic Michael , Thiyagarajah Keerthihan , Glitscher Mirco , Schollmeier Anja , Wu Qingyan , Görgülü Esra , Lembeck Pia , Sonnenberg Jannik , Dietz Julia , Finkelmeier Fabian , Praktiknjo Michael , Trebicka Jonel , Zeuzem Stefan , Sarrazin Christoph , Hildt Eberhard , Peiffer Kai‐Henrik 
Published: July 2024

AbstractBackgroundThe hepatitis B e antigen (HBeAg)‐negative infection Phase 3 is characterized by no or minimal signs of hepatic inflammation and the absence of hepatic fibrosis. However, underlying molecular mechanisms leading to this benign phenotype are poorly understood.MethodsGenotype A, B and D HBeAg‐negative patient isolates with precore mutation G1896A from Phase 3 were analysed in comparison with respective HBeAg‐positive rescue mutant and HBeAg‐positive wild‐type reference genomes regarding differences in viral replication, morphogenesis, infectivity and impact on NF‐E2‐related factor 2 (Nrf2)/antioxidant response element (ARE)‐dependent gene expression and cellular kinome.ResultsIn comparison with reference genomes, the patient isolates are characterized by a lower intra‐ and extracellular hepatitis B surface antigen (HBsAg)‐amount, and HBsAg‐retention in the endoplasmic reticulum. Rescue of HBeAg expression increased HBsAg‐amount but not its release. Expression of the isolated genomes is associated with a higher Nrf2/ARE‐dependent gene expression as compared to reference genomes independent of HBeAg expression. Kinome analyses revealed a decreased activity of receptors involved in regulation of proliferative pathways for all patient isolates compared to the reference genomes. No specific conserved mutations could be found between all genomes from Phase 3.ConclusionsHBeAg‐negative genomes from Phase 3 exhibit distinct molecular characteristics leading to lower HBsAg synthesis and release, enhanced oxidative stress protection and decreased activity of key kinases, triggering an antiproliferative stage, which might contribute to the lower probability of hepatocellular carcinoma. The observed differences cannot be associated with loss of HBeAg or specific mutations common to all analysed isolates, indicating the phenotype of Phase 3 derived genomes to be the result of a multifactorial process likely reflecting a conserved natural selection process.