bluuebunny/crossref_metadata_2025_split huggingface dataset:
Future temporal reference in child language
Authors: Weist Richard M. 
Published: August 2014

AbstractThis chapter investigates the acquisition of future temporal reference in child language within the framework of the emergence of the ‘Event time’ and the ‘Reference time’ temporal systems and within a cross-linguistic perspective. The chapter probes the developmental language–thought relationship between the emergence of the event time and the reference time systems in the child’s language and the child’s capacity for autobiographical memory and ‘episodic future thinking’. An argument for a precocious understanding of the deictic relations of the child’s tense morphology is presented. Further, the chapter explains how children acquire the capacity to establish reference time at relatively remote locations away from speech time creating a complex system of temporal reference. These accomplishments in child language are linked to the conceptual capacity for past and future time travel, re-experiencing and pre-experiencing episodic representations. The potential relevance of the Whorfian hypothesis as it applies to child language and future temporal reference is explored.
On future in commands
Authors: Aikhenvald Alexandra Y. 
Published: August 2014

AbstractThe expression of future time and tense can correlate with sentence types. As predicted by Lyons (1977: 746–7), the most frequently attested grammaticalized time reference in imperatives is that of immediate versus delayed—or future—imperative. This contrasts with a wider range of possibilities for future meanings grammaticalized in declarative clauses. The grammatical distinction of immediate and future imperative is widely attested in North American Indian languages. Future imperatives may have overtones of politeness (as in Epena Pedee, a Chocoan language from Colombia, and in Yup’ik). Some languages distinguish ‘near future’ and ‘remote future’ imperatives (e.g. Koasati, a Muskogean language). An essentially temporal distinction in imperatives may also correlate with spatial distance. This chapter offers a discussion of future meanings expressed in imperatives across the world’s languages (using Aikhenvald 2010: 130–3 as a point of departure).
Future reference and current relevance with the French composed past
Authors: de Saussure Louis 
Published: August 2014

AbstractThis chapter investigates reference to future eventualities with the composed past in French. The French composed past has an ambiguous meaning, corresponding to either a present perfect or a narrative past, while being compatible with future temporal adverbs and has, therefore, a theoretically unexpected future meaning. The chapter argues that a Futurate Composed Past utterance (FCP) expresses a future state resulting from a prior eventuality and suggests that this temporal reference is pragmatically constructed in the search for relevance through a perspectival shift implying a point of view situated by the future adverb, from which the state of affairs is considered true. The difference between FCP and Anterior Future utterances may reside in the fact that the FCP triggers a pragmatic deontic-practical modality—has concrete implications about what to do in the actual present—contrary to what is obtained with the Anterior Future. It is suggested that this is achieved through simulative cognitive processes.
Modeling Commodity Prices with Dynamic Conditional Beta
Authors: Engle Robert 
Published: August 2014

AbstractThe Dynamic Conditional Beta model is applied to the returns on 21 commodities to examine evidence of transitions in the market structure. The econometrics of transition models is examined from the influential perspective of Timo Teräsvirta’s smooth transition models. The betas on the SP500 are estimated dynamically and reveal big increases associated with the financial crisis and the increasing role of mainstream financial traders. Shocks to commodity markets in earlier periods were arguably more likely to be supply shocks that were uncorrelated with broad equity indices, whereas the financial crisis was a demand shock to this sector and increased the correlation and beta on the indices. The hedging value of commodities is clearly reduced but it appears that most commodities still have a role in a minimum variance portfolio.
Solutions of the Navier–Stokes Equations
Authors: Ruban Anatoly I. , Gajjar Jitesh S. B. 
Published: August 2014

Abstract
This chapter describes solutions of the Navier–Stokes equations, starting with simple physical situations where these equations allow exact solutions, i.e. solutions in analytic form. These include Couette flow between two parallel plates, Hagen–Poiseuille flow through a pipe, flow above an impulsively started plate (where the notion of a self-similar solution and the Stokes layer are introduced), dissipation of the potential vortex caused by fluid viscosity, and Kármán flow above an infinite rotating disk. Some numerical solutions of the Navier–Stokes equations are then presented to illustrate various important properties of viscous flows. Flow past a circular cylinder is examined, and it is shown what happens to the separation eddy region behind the cylinder as the Reynolds number increases. The behaviour of flow in a cavity is also discussed, and it is demonstrated how recirculating eddies can multiply as the fluid viscosity decreases.
Elements of Gasdynamics
Authors: Ruban Anatoly I. , Gajjar Jitesh S. B. 
Published: August 2014

Abstract
This chapter deals with inviscid compressible flows of a perfect gas. It starts with an analysis of small perturbations propagating through a gas at rest using piston theory and then turns to integrals of motion, including compressible versions of the Bernoulli equation, entropy conservation law, and Kelvin’s Circulation Theorem. Crocco’s formula, which allows determination of whether a flow is potential in the presence of shock waves, is derived. The theory of characteristics is formulated for two-dimensional potential flows and applied to Prandtl–Meyer flow over a body surface bend and flow past a corner. The formation of shock waves, normal or oblique, is discussed. The shock conditions are deduced and the shock polar, which describes the behaviour of oblique shocks, is introduced. These results are applied to flows past a wedge and a circular cone. Finally, unsteady compressible flows are analysed, in particular shock tubes and blast waves are considered.
OptiType: precision HLA typing from next-generation sequencing data
Authors: Szolek András , Schubert Benjamin , Mohr Christopher , Sturm Marc , Feldhahn Magdalena , Kohlbacher Oliver 
Published: August 2014

Abstract
Motivation: The human leukocyte antigen (HLA) gene cluster plays a crucial role in adaptive immunity and is thus relevant in many biomedical applications. While next-generation sequencing data are often available for a patient, deducing the HLA genotype is difficult because of substantial sequence similarity within the cluster and exceptionally high variability of the loci. Established approaches, therefore, rely on specific HLA enrichment and sequencing techniques, coming at an additional cost and extra turnaround time.
Result: We present OptiType, a novel HLA genotyping algorithm based on integer linear programming, capable of producing accurate predictions from NGS data not specifically enriched for the HLA cluster. We also present a comprehensive benchmark dataset consisting of RNA, exome and whole-genome sequencing data. OptiType significantly outperformed previously published in silico approaches with an overall accuracy of 97% enabling its use in a broad range of applications.
Contact: szolek@informatik.uni-tuebingen.de
Supplementary information: Supplementary data are available at Bioinformatics online.
GlycoPattern: a web platform for glycan array mining
Authors: Agravat Sanjay B. , Saltz Joel H. , Cummings Richard D. , Smith David F. 
Published: August 2014

Abstract
Summary: GlycoPattern is Web-based bioinformatics resource to support the analysis of glycan array data for the Consortium for Functional Glycomics. This resource includes algorithms and tools to discover structural motifs, a heatmap visualization to compare multiple experiments, hierarchical clustering of Glycan Binding Proteins with respect to their binding motifs and a structural search feature on the experimental data.
Availability and implementation: GlycoPattern is freely available on the Web at http://glycopattern.emory.edu with all major browsers supported.
Contact: sanjay.agravat@emory.edu
Planet X revamped after the discovery of the Sedna-like object 2012 VP113?
Authors: Iorio L. 
Published: August 2014

Abstract
The recent discovery of the Sedna-like dwarf planet 2012 VP113 by Trujillo and Sheppard has revamped the old-fashioned hypothesis that a still unseen trans-Plutonian object of planetary size, variously dubbed over the years as Planet X, Tyche and Telisto, might lurk in the distant peripheries of the Solar system. This time, the presence of a super-Earth with mass mX =2–15 m⊕ at a distance dX ≈ 200–300 astronomical units (au) has been proposed to explain the observed clustering of the arguments of perihelion ω near ω ≈ 0° but not ω ≈ 180° for Sedna, 2012 VP113 and other minor bodies of the Solar system with perihelion distances q &gt; 30 au and semimajor axes a &gt; 150 au. Actually, such a scenario is strongly disfavoured by the latest constraints $\Delta \dot{\varpi }$ on the anomalous perihelion precessions of some Solar system planets obtained with the INPOP and EPM ephemerides. Indeed, they yield dX ≳ 496–570 au (mX = 2 m⊕) and dX ≳ 970–1111 au (mX = 15 m⊕). Much tighter constraints could be obtained in the near future from the New Horizons mission to Pluto.
The rarity of star formation in brightest cluster galaxies as measured by WISE
Authors: Fraser-McKelvie Amelia , Brown Michael J. I. , Pimbblet Kevin A. 
Published: August 2014

Abstract
We present the mid-infrared star formation rates of 245 X-ray selected, nearby (z &lt; 0.1) brightest cluster galaxies (BCGs). A homogeneous and volume limited sample of BCGs was created by X-ray selecting clusters with Lx &gt; 1 × 1044 erg s− 1. The Wide-Field Infrared Survey Explorer (WISE) All WISE Data Release provides the first measurement of the 12 μm star formation indicator for all BCGs in the nearby Universe. Perseus A and Cygnus A are the only galaxies in our sample to have star formation rates of &gt; 40 M⊙ yr− 1, indicating that these two galaxies are highly unusual at current times. Stellar populations of 99 ± 0.6 per cent of local BCGs are (approximately) passively evolving, with star formation rates of &lt; 10 M⊙ yr− 1. We find that in general, star formation produces only modest BCG growth at the current epoch.
Novel applications of statins for bone regeneration
Authors: Shah Sarita R. , Werlang Caroline A. , Kasper F. Kurtis , Mikos Antonios G. 
Published: August 2014

Abstract
The use of statins for bone regeneration is a promising and growing area of research. Statins, originally developed to treat high cholesterol, are inhibitors of the enzyme 3-hydroxy-3-methylglutaryl, the rate-limiting enzyme of the mevalonate pathway. Because the mevalonate pathway is responsible for the synthesis of a wide variety of important biochemical molecules, including cholesterol and other isoprenoids, the effects of statins are pleiotropic. In particular, statins can greatly affect the process of bone turnover and regeneration via effects on important cell types, including mesenchymal stem cells, osteoblasts, endothelial cells, and osteoclasts. Statins have also been shown to have anti-inflammatory and antimicrobial properties that may be useful since infection can derail normal bone healing. This review will explore the pleiotropic effects of statins, discuss the current use of statins for bone regeneration, particularly with regard to biomaterials-based controlled delivery, and offer perspectives on the challenges and future directions of this emerging area of bone tissue engineering.
Voriconazole-Resistant Penicillium oxalicum: An Emerging Pathogen in Immunocompromised Hosts
Authors: Chowdhary Anuradha , Kathuria Shallu , Agarwal Kshitij , Sachdeva Neelam , Singh Pradeep K. , Jain Sandeep , Meis Jacques F. 
Published: August 2014

Abstract
Penicillium species are rarely reported agents of infections in immunocompromised patients. We report 3 cases of invasive mycosis caused by voriconazole-resistant Penicillium oxalicum in patients with acute myeloid leukemia, diabetes mellitus, and chronic obstructive pulmonary disease, while on voriconazole therapy. Penicillium oxalicum has not been previously recognized as a cause of invasive mycoses.
Phase II Study of Modified FOLFOX6 With Bevacizumab in Metastatic Gastroesophageal Adenocarcinoma
Authors: Li Jia , Yao Xiaopan , Kortmansky Jeremy S. , Fischbach Neal A. , Stein Stacey , Deng Yanhong , Zhang Yue , Doddamane Indukala , Karimeddini David , Hochster Howard S. , Lacy Jill 
Published: August 2014

Background:
The median survival for patients with metastatic gastroesophageal adenocarcinoma is <12 months. Bevacizumab has demonstrated promising activity in metastatic gastroesophageal adenocarcinoma when used in combination with cisplatin-based regimens for patients from the Americas. We conducted a prospective phase II trial to investigate the efficacy of bevacizumab in combination with the oxaliplatin-based regimen, modified FOLFOX6, in patients with metastatic gastroesophageal adenocarcinoma.

Methods:
Patients with untreated metastatic adenocarcinoma of the stomach, gastroesophageal junction, or distal esophagus received mFOLFOX6 (leucovorin 400 mg/m2, fluorouracil 400 mg/m2 bolus and 2400 mg/m2 continuous infusion over 46 h, oxaliplatin 85 mg/m2) and bevacizumab (10 mg/kg) every 2 weeks until disease progression or intolerance. Response by RECIST was evaluated by CT scan every 8 weeks. The primary objective was progression-free survival (PFS); secondary objectives were safety, response rate, and overall survival (OS).

Results:
A total of 39 patients with untreated metastastic gastroesophageal adenocarcinoma were enrolled between September 2008 and June 2012. Median number of cycles administered was 12 (range, 4 to 86). The confirmed response rate was 56.4% (3 complete response and 19 partial response). The median PFS was 7.8 months and median OS was 14.7 months. Three patients remain on treatment, and 11 patients are alive, of whom 6 have survived >24 months. Treatment-related grade 3/4 toxicities included neutropenia (33.3%), neuropathy (20.5%), thromboembolism (VTE) (7.7%), thrombocytopenia (7.7%), anemia (2.6%), hypertension (2.6%), and proteinuria (2.6%). We observed no GI perforations or grade 3/4 GI hemorrhagic events.

Conclusions:
First-line mFOLFOX6 with bevacizumab for metastatic gastroesophageal adenocarcinoma was well tolerated and associated with longer PFS and OS compared with historical data from similar populations treated without bevacizumab. Our results suggest that the addition of bevacizumab to mFOLFOX6 may provide clinical benefit in American patients with metastatic gastroesophageal adenocarcinoma, a finding consistent with previous studies of first-line bevacizumab in combination with chemotherapy for this disease.
House builder opinions of energy-efficient homes in the UK
Authors: Callaghan Nicola , Sommerville James , Craig Nigel 
Published: August 2014

Purpose
– This paper aims to study house builder opinions of energy-efficient homes in the UK. The days of inconsiderate construction methods and disregard for the environment are becoming a thing of the past. If zero carbon (Zc) standards are to be implemented across all new homes within the UK, it is essential that house builders are willing and able to construct such homes to the necessary standards and to the volumes required. Although new generations of low carbon (Lc) and energy-efficient homes are beginning to break into the marketplace, house builders remain reluctant to introduce complex technologies during high effort builds.

Design/methodology/approach
– The findings from questionnaire responses provide an indication of the views of house builders relating to the incentives encouraging and barriers preventing them from producing mass market energy-efficient homes.

Findings
– This paper has uncovered the views and opinions of house builders relating to energy-efficient homes. The findings provide evidence that the house building industry is not fully engaged with the energy-efficiency concept; that house builders portray an inconsistent level of confidence in their ability to deliver energy-efficient homes; and that Government targets are too ambitious.

Originality/value
– The findings within this paper provide an overview of the opinions of house builders relating to energy-efficient homes using statistical analysis.
Efficiency of project health checks (PHCs) as an early warning system in practice
Authors: Haji-Kazemi Sara , Andersen Bjorn 
Published: August 2014

Purpose
– The purpose of this paper is to present an overview on the concept of early warning (EW) signs in projects, briefly introduce the project health check (PHC) tool, and evaluate the level of efficiency of this tool as a source of data for an EW approach signaling that a project is about to experience problems in the future.

Design/methodology/approach
– Two case projects from the telecommunication industry which have implemented the PHC system were investigated in order to observe how the use of this approach can help indicate EW signs which arise in projects and specify the area in which the problem is about to occur. A combination of qualitative and quantitative research methods has been implemented.

Findings
– The results show that although the application of PHC tool can to a certain extent contribute to identification of EW signs in projects but level of effectiveness of the PHC this tool as an EW system is dependent on several factors such as level of complexity of the project, average experience of project managers, etc. Also the empirical studies reveal that there is definitely potential for enhancement of the tool in order to improve its utilization as an EW system.

Research limitations/implications
– The research is limited to a single organization in the telecommunication industry. The projects are within the execution phase and the final outcomes of the projects are yet not acquired.

Practical implications
– The empirical case studies were developed to illustrate the level of efficiency of the use of PHC tool in projects and show how this tool can be used in order to better realize the potential problems timely enough to take preventive actions.

Originality/value
– This paper highlights the gap in the literature concerning the practical use of PHC/project health indicator tool as an EW system. It offers a new idea on how PHC tool can be used as an effective EW system and shed light on the factors which influence the reliability and validity of the data obtained via this tool in project. This paper is intended to be primarily of use to project management practitioners and practically oriented academics who are interested in developing fresh insights into new approaches for better management of projects.
Mentorship in academia
Authors: Zackariasson Peter 
Published: August 2014

Purpose
– The importance of mentorship in academia is discussed, and in particular the work of Timothy L. Wilson who has been instrumental for the author in this respect is described. Drawing on historical practices from academia and the arts, the purpose of this paper is to communicate why and how mentorship could be applied.

Design/methodology/approach
– As a conceptual paper this draws knowledge from the author's experience.

Findings
– The general message concerns the importance of mentorship in order to create a vibrant (and sustainable) academic community.

Originality/value
– The value of this paper is twofold: primarily it celebrates Timothy L. Wilson as a model to mentorship in academia, second it communicates the importance of mentorship per se.
Indicators of best practices in technology product development projects
Authors: Iamratanakul Supachart , F. Badir Yuosre , Siengthai Sununta , Sukhotu Vatcharapol 
Published: August 2014

Purpose– The purpose of this paper is to rank the importance of the critical success factors (CSFs) for best practices in technology product development in the Thailand electronics industry and to determine the relationships between these factors in terms of their impact on project success.Design/methodology/approach– Interviews with experts and a review of past studies are used to design an instrument for data collection. A case analysis is conducted to classify CSFs. Interpretive structural modeling (ISM) methodology is applied to analyze CSFs and investigate their relationships.Findings– The authors identified 14 “driving” and “dependent” factors, which were then classified into four factor categories: linkage, autonomous, dependent, or independent factors. The results show that strategic alignment was the most significant CSF. Three factors which had a high driving power and were less dependent on others were: follow-up work, co-ordination, and relationships with clients.Practical implications– The results may inform and assist technology project management in the little understood business cultures of the developing world. These finding may allow practitioners to prioritize the factors that drive project success when allocating their limited resources.Originality/value– This research contributes to the field of project management by identifying the relative importance of the CSFs which enhance the management of technology projects. Despite the abundance of studies on CSFs, their importance has still not been fully explained. The findings provide insights into the degree of importance of the factors and their interdependencies, which can either drive or undermine project success. In addition, the ISM methodology the authors used is a unique approach in the project management field.
Honesty in projects
Authors: Kvalnes Øyvind 
Published: August 2014

Purpose
– The purpose of this paper is to explore how the concept of honesty can shed light on misreporting issues in projects. Research on honesty can be useful for practitioners and researchers in project management, in order to understand and counter the withholding and distortion of relevant information from projects. In moral psychology, dishonesty is often explained as a result of moral neutralization. The paper provides an account of how neutralization can lead to dishonesty in projects.

Design/methodology/approach
– The current study is based on a literature review of research on misreporting and dishonesty in projects, and of relevant generic studies of honesty.

Findings
– The author concludes that the phenomenon of moral neutralization can explain dishonesty and misreporting in projects. Honesty can be encouraged by identifying attempts at moral neutralization, and rendering them unacceptable. At the core of this position is the view that the level of honesty amongst project members is most adequately understood and explained from a circumstance rather than a character approach.

Research limitations/implications
– The paper is based on a literature review, and needs to be supported by further empirical studies within project management.

Practical implications
– The suggested primacy of a circumstance approach to honesty implies that project practitioners should be aware of the phenomenon of moral neutralization. Even people of good moral character can become involved in neutralization, in order to render misreporting acceptable. The central practical challenge can thus be to recognize tendencies of neutralization in one's own and other people's moral reasoning.

Originality/value
– The main contribution of this paper is to introduce the concept of honesty in general, and the concept of moral neutralization in particular, to project management research and practice. The paper also suggests concrete ways to redirect attention from character to circumstances, based on more general research findings in social and moral psychology.