bluuebunny/crossref_metadata_2025_split huggingface dataset:
Die Olympischen Spiele in Rio de Janeiro 2016
Authors: Göppert, Knut , Stockhusen Knut 
Published: June 2014

AbstractIm Dezember 2012 wurde die Entscheidung der öffentlichen Ausschreibungen zur Planung der olympischen Tennis‐ und der Schwimmanlage (Bild 1) bekanntgegeben. Das Konsortium, bestehend aus schlaich bergermann und partner sbp do brasil und Gerkan, Marg und Partner gmp do brasil, gemeinsam mit den brasilianischen Haustechnik‐ und Nachhaltigkeitspartnern Lumens und Sustentech, hatte beide Projekte für sich entscheiden können. Dies markierte die Aufnahme in den exklusiven Klub der Planer für Olympische Spiele und die endgültige Anerkennung als vollumfänglich brasilianisch registriertes und für öffentliche Ausschreibungen zugelassenes Büro.The Olympic Games 2016 in Rio de Janeiro. In December 2012, the decision of the public tender for the planning of the Olympic Games venues of tennis and aquatic facilities (figure 1) was announced. The consortium, consisting of schlaich bergermann und partner sbp do brasil and Gerkan, Marg und Partner gmp do brasil, together with the Brazilian mechanical engineering and sustainability partners Lumens and Sustentech, was successful in both projects. This high‐lighted the admission to the exclusive club of planners for the Olympic Games and the final confirmation of the recognition as a fully registered Brazilian office, accredited for public bids.
Was ist Ingenieurbaukunst?
Authors: Kurrer Karl‐Eugen 
Published: June 2014

AbstractIm Rahmen des Ingenieurbaupreises 2013 von Ernst & Sohn interviewte das online‐Magazin für Ingenieure – “momentum“ – die Mitglieder der Jury (Bild 1). Die Videos gingen Ende Januar 2013 online. Nach Verbreitung des Interviews mit dem Autor dieser Zeilen schlug ihm Jörg Schlaich vor, eine schriftliche Fassung des Interviews http://momentum‐magazin.de/de/ibpreis2013‐kurrer/ zu veröffentlichen, was hiermit nachgeholt werden soll.
The effect of gender medicine education in GP training: a prospective cohort study
Authors: Dielissen Patrick , Verdonk Petra , Waard Magreet Wieringa-de , Bottema Ben , Lagro-Janssen Toine 
Published: June 2014

The purpose of this study is to compare the change in general practitioner (GP) trainees’ gender awareness following a modular gender medicine programme or a mainstream gender medicine programme. In 2007, a prospective study was conducted in three cohorts of in total 207 GP trainees who entered GP training in the Netherlands. The outcome measure was the Nijmegen Gender Awareness in Medicine Scale and a 16-item gender knowledge questionnaire. Two gender medicine teaching methods were compared: a modular approach (n = 75) versus a mainstream approach (n = 72). Both strategies were compared with a control cohort (n = 60). Statistical analysis included analysis of variance and t-tests. The overall response rates for the modular, mainstream and control cohort were 78, 72 and 82 %, respectively. There was a significant difference in change in gender knowledge scores between the modular cohort compared with the mainstream and control cohort (p = 0.049). There were no statistical differences between the cohorts on gender sensitivity and gender role ideology. At entry and end, female GP trainees demonstrated significantly higher gender awareness than male GP trainees. A modular teaching method is not a more favourable educational method to teach gender medicine in GP training. Female GP trainees are more gender aware, but male GP trainees are not unaware of gender-related issues.
Atomistics of superlubricity
Authors: Hirano Motohisa 
Published: June 2014

Abstract
Friction is a phenomenon observed ubiquitously in daily life, yet its nature is complicated. Friction between rough surfaces is considered to arise primarily because of macroscopic roughness. In contrast, interatomic forces dominate between clean and smooth surfaces. “Superlubricity”, where friction effectively becomes zero, occurs when the ratio of lattice parameters in the pair of surfaces becomes an irrational number. Superlubricity has been found to exist in a limited number of systems, but is a very important phenomenon both in industry and in mechanical engineering. New atomistic research on friction is under way, with the aim of refining theoretical models that consider interactions between atoms beyond mean field theory and experiments using ultrahigh vacuum non-contact atomic force microscopy. Such research is expected to help clarify the nature of microscopic friction, reveal the onset conditions of friction and superlubricity as well as the stability of superlubricity, discover new superlubric systems, and lead to new applications.
Mental health impacts of reproductive coercion among women in Côte d'Ivoire
Authors: McCauley Heather L. , Falb Kathryn L. , Streich‐Tilles Tara , Kpebo Denise , Gupta Jhumka 
Published: June 2014

AbstractObjectiveTo assess the independent associations of partner‐perpetrated reproductive coercion, intimate partner violence (IPV), in‐law reproductive coercion, and in‐law abuse with recent probable post‐traumatic stress disorder (PTSD), and to test their relationship with PTSD symptoms when controlling for the other types of abuse among partnered women in rural Côte d'Ivoire.MethodsCross‐sectional analyses were conducted using logistic generalized estimating equations, which accounted for village‐level clustering. Data were drawn from baseline data from a randomized controlled trial among 24 villages in rural Côte d'Ivoire (n = 953 partnered women). Three adjusted models were used to test associations of reproductive coercion and abuse with probable PTSD.ResultsPartner‐perpetrated reproductive coercion was experienced by 176 (18.5%) women. In model 3, which accounted for the co‐occurrence of abuses, partner‐perpetrated reproductive coercion (odds ratio [OR] 2.3; 95% confidence interval [CI], 1.4–3.9) and partner‐perpetrated IPV (OR 1.7; 95% CI, 1.1–2.7) were the most significant predictors of past‐week probable PTSD (P < 0.05).ConclusionReproductive coercion may be a significant contributor to poor mental health. The mental health impacts of reproductive coercion and IPV should be considered within psychosocial programming for rural Ivorian communities to address the full range of traumatic experiences that may have been experienced by women.
Regularities of distribution and composition of heteroatomic components in Paleozoic and Jurassic oils of southeastern West Siberia
Authors: Sagachenko T.A. , Gerasimova N.N. , Kovalenko E.Yu. , Sergun V.P. , Min R.S. 
Published: June 2014

Abstract
Experimental data on the distribution and composition of sulfur and nitrogen compounds in oils of Paleozoic and Jurassic deposits of southeastern West Siberia have been summarized. Benzo-, dibenzo-, and naphthobenzothiophene, quinolines and benzoquinolines, thiopheno- and benzothiophenoquinolines, and benzo- and dibenzoquinolones are shown to be the main hetero-organic compounds in all the oils. It has been established that the distribution of these compounds depends on the formation conditions of natural hydrocarbon systems and on the degree of their catagenesis.
The Welfare Impacts of Bird Damage and Its Control in California Wine Grape Production
Authors: Anderson A. , Lindell C. A. , Siemer W. F. , Shwiff S. A. 
Published: June 2014

AbstractWe developed a partial equilibrium model to examine the welfare impacts of bird damage and its control in California wine grape production. The model incorporates the impacts of pest damage and its control and allows the impacts to vary regionally. Importantly, the model requires minimal information to apply; only elasticities, current market price and production data, and information on the cost and effectiveness of the pest control methods are needed. We rely on data from a recent survey of California growers and use the model to estimate changes in wine grape prices, production levels, and consumer and producer surplus that result from both bird damage and its control in three grape-growing regions of California. Results suggest that eliminating the threat of bird damage and control costs results in an increase in producer and consumer surplus of 1.3% and 3%, respectively. Furthermore, eliminating current bird control and allowing any resulting damage would decrease producer and consumer surplus by 6.6% and 11.5%, respectively. (JEL Classifications: Q11, Q18, Q57)
The quality of reporting of phase II and III trials for new antipsychotics: a systematic review
Authors: Patel M. X. , Collins S. , Hellier J. , Bhatia G. , Murray R. M. 
Published: June 2014

BackgroundThe findings of the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) study and the Cost Utility of the Latest Antipsychotic Drugs in Schizophrenia Study (CUtLASS) called previous trials of antipsychotics into question, including pre-licensing trials. Concerns regarding methodological robustness and quality of reporting increased. This systematic review aimed to examine the quality of reporting of phase II and III trials for new antipsychotics in the aftermath of the CATIE and CUtLASS studies.MethodElectronic searches were conducted in EMBASE, Medline and Cochrane databases and also ClinicalTrials.gov for antipsychotic trials (published between January 2006 and February 2012). Phase II and III randomized controlled trials (RCTs) for iloperidone, asenapine, paliperidone, olanzapine, lurasidone and pomaglumetad methionil were selected for schizophrenia and schizoaffective disorder. The reporting of the methodology was evaluated in accordance with Consolidated Standards of Reporting Trials (CONSORT) guidelines.ResultsThirty-one articles regarding 32 studies were included. There was insufficient reporting of design in 47% of studies and only 13% explicitly stated a primary hypothesis. Exclusion criteria were poorly reported for diagnosis in 22% of studies. Detail regarding comparators, particularly placebos, was suboptimal for 56% of studies, and permitted concomitant medication was often not reported (19%). Randomization methods were poorly described in 56% of studies and reporting on blinding was insufficient in 84% of studies. Sample size calculations were insufficiently reported in 59% of studies.ConclusionsThe quality of reporting of phase II and III trials for new antipsychotics does not reach the standards outlined in the CONSORT guidelines. Authors often fail to adequately report design and methodological processes, potentially impeding the progress of research on antipsychotic efficacy. Both policymakers and clinicians require high quality reporting before decisions are made regarding licensing and prescribing of new antipsychotics.
Ageing Organisations and the Extension of Working Lives: A Case Study Approach
Authors: CONEN WIETEKE , HENKENS KÈNE , SCHIPPERS JOOP 
Published: June 2014

AbstractThis paper examines how the economic climate and policy changes at national level have been affecting organisational practices, aimed at the extension of working lives of older workers, over the last decade. We analyse case studies conducted among Dutch organisations. Our findings show that personnel policies are typically short-term oriented and vary in their existence and content congruous to the economic climate. Policy changes in retirement arrangements, and the debate about raising the official retirement age, have made both employees and employers realise that the extension of working lives has become an unavoidable fact, although both parties still seem intrinsically opposed to it. Changes to safety regulations and the increase in costs for employers if employees drop out of work due to ill health have led to an increasing focus on health-related measures in professions with intense physical work over the last decade. We conclude that, while national level policy changes in areas like health and safety do percolate down and begin to affect organisational practice, it is at the organisational level that they still need to be worked through.
Lack of BCG vaccination and other risk factors for bacteraemia in severely malnourished children with pneumonia
Authors: CHISTI M. J. , SALAM M. A. , AHMED T. , SHAHID A. S. M. S. B. , SHAHUNJA K. M. , FARUQUE A. S. G. , BARDHAN P. K. , HOSSAIN M. I. , ISLAM M. M. , DAS S. K. , HUQ S. , SHAHRIN L. , HUQ E. , CHOWDHURY F. , ASHRAF H. 
Published: June 2014

SUMMARYWe sought to examine the factors associated with bacteraemia and their outcome in children with pneumonia and severe acute malnutrition (SAM). All SAM children of either sex, aged 0–59 months, admitted to the Dhaka Hospital of the International Centre for Diarrhoeal Disease Research, Bangladesh with radiologically confirmed pneumonia from April 2011 to July 2012 were enrolled (n = 405). Comparison was made between pneumonic SAM children with (cases = 18), and without (controls = 387) bacteraemia. The death rate was significantly higher in cases than controls (28% vs. 8%, P < 0·01). In logistic regression analysis, after adjusting for potential confounders, the SAM children with pneumonia and bacteraemia more often had a history of lack of bacillus Calmette-Guérin (BCG) vaccination (odds ratio 7·39, 95% confidence interval 1·67–32·73, P < 0·01). The results indicate the importance of continuation of BCG vaccination which may provide benefit beyond its primary purpose.
Uncommon aetiological agents of catheter-related bloodstream infections
Authors: REIGADAS E. , RODRÍGUEZ-CRÉIXEMS M. , SÁNCHEZ-CARRILLO C. , MARTÍN-RABADÁN P. , BOUZA E. 
Published: June 2014

SUMMARYThe clinical and microbiological characteristics of catheter-related bloodstream infection (CR-BSI) due to uncommon microorganisms was assessed in a retrospective case-control study over a 9-year period in a tertiary teaching hospital. Uncommon microorganisms were defined as those representing <0·5% of all CR-BSI. Diagnosis of CR-BSI required that the same microorganism was grown from at least one peripheral venous blood culture and a catheter tip culture. Thirty-one episodes of CR-BSI were identified due to 13 different genera and these accounted for 2·3% of all CR-BSI in the hospital. Although these infections were not associated with increased mortality, they occurred in patients with more severe underlying conditions who were receiving prolonged antibiotic therapy.
Ecological theory as a foundation to control pathogenic invasion in aquaculture
Authors: De Schryver Peter , Vadstein Olav 
Published: June 2014

Abstract
Detrimental host–pathogen interactions are a normal phenomenon in aquaculture animal production, and have been counteracted by prophylactic use of antibiotics. Especially, the youngest life stages of cultivated aquatic animals are susceptible to pathogen invasion, resulting in disease and mortality. To establish a more sustainable aquatic food production, there is a need for new microbial management strategies that focus on ‘join them’ and not the traditional ‘beat them’ approaches. We argue that ecological theory could serve as a foundation for developing sustainable microbial management methods that prevent pathogenic disease in larviculture. Management of the water microbiota in aquaculture systems according to ecological selection principles has been shown to decrease opportunistic pathogen pressure and to result in an improved performance of the cultured animals. We hypothesize that manipulation of the biodiversity of the gut microbiota can increase the host’s resistance against pathogenic invasion and infection. However, substantial barriers need to be overcome before active management of the intestinal microbiota can effectively be applied in larviculture.
Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues
Authors: Guo Zhiyun , Maki Miranda , Ding Ruofan , Yang Yalan , zhang Bao , Xiong Lili 
Published: June 2014

AbstractTissue-specific miRNAs (TS miRNA) specifically expressed in particular tissues play an important role in tissue identity, differentiation and function. However, transcription factor (TF) and TS miRNA regulatory networks across multiple tissues have not been systematically studied. Here, we manually extracted 116 TS miRNAs and systematically investigated the regulatory network of TF-TS miRNA in 12 human tissues. We identified 2,347 TF-TS miRNA regulatory relations and revealed that most TF binding sites tend to enrich close to the transcription start site of TS miRNAs. Furthermore, we found TS miRNAs were regulated widely by non-tissue specific TFs and the tissue-specific expression level of TF have a close relationship with TF-genes regulation. Finally, we describe TSmiR (http://bioeng.swjtu.edu.cn/TSmiR), a novel and web-searchable database that houses interaction maps of TF-TS miRNA in 12 tissues. Taken together, these observations provide a new suggestion to better understand the regulatory network and mechanisms of TF-TS miRNAs underlying different tissues.
Picture Naming and Verbal Fluency in Children With Cochlear Implants
Authors: Wechsler-Kashi Deena , Schwartz Richard G. , Cleary Miranda 
Published: June 2014

Purpose
In the present study, the authors examined lexical naming in children with cochlear implants (CIs). The goal was to determine whether children with CIs have deficits in lexical access and organization as revealed through reaction time in picture-naming and verbal fluency (VF) experiments.

Method

Children with CIs (
n
= 20, ages 7–10) were compared with 20 children with normal hearing (NH) matched for age and nonverbal IQ. Lexical abilities were examined using two naming tasks: a timed picture-naming task and a phonological and semantic VF naming task. Picture naming taps into lexical access capabilities and the VF task elucidates lexical organization.

Results
No group differences were found between children with CIs and children with NH on the timed picture-naming task. Children with CIs generated significantly fewer words than the children with NH on the VF tasks. Larger group differences were found for the phonological VF task compared with the semantic VF task.

Conclusions
Limited early linguistic and auditory experiences may affect lexical representations and organization (lexical-semantic connections) in school-age children with hearing loss who use CIs. Further analyses and studies should continue to examine these underlying linguistic deficits. The present results suggest a need to emphasize not only increasing the size of children's vocabularies during therapy, but also expanding and increasing the semantic and phonological richness of their lexical representations.
Processing multiple visual objects is limited by overlap in neural channels
Authors: Cohen Michael A. , Konkle Talia , Rhee Juliana Y. , Nakayama Ken , Alvarez George A. 
Published: June 2014

Significance
Human cognition is inherently limited: only a finite amount of visual information can be processed at a given instant. What determines those limits? Here, we show that more objects can be processed when they are from different stimulus categories than when they are from the same category. This behavioral benefit maps directly onto the functional organization of the ventral visual pathway. These results suggest that our ability to process multiple items at once is limited by the extent to which those items compete with one another for neural representation. Broadly, these results provide strong evidence that the capacities and limitations of human behavior can be inferred from our functional neural architecture.
Deep mantle structure as a reference frame for movements in and on the Earth
Authors: Torsvik Trond H. , van der Voo Rob , Doubrovine Pavel V. , Burke Kevin , Steinberger Bernhard , Ashwal Lewis D. , Trønnes Reidar G. , Webb Susan J. , Bull Abigail L. 
Published: June 2014

SignificanceSince the Pangea supercontinent formed about 320 million years ago, plumes that sourced large igneous provinces and kimberlites have been derived from the edges of two stable thermochemical reservoirs at the core–mantle boundary. We test whether it is possible to maintain this remarkable surface-to-deep Earth correlation before Pangea through the development of a new plate reconstruction method and find that our reconstructions for the past 540 million years comply with known geological and tectonic constraints (opening and closure of oceans, mountain building, and more). These results have important implications for Earth history, including the style of mantle convection in the deep past and the long-term stability of mantle reservoirs.
Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2
Authors: De Haes Wouter , Frooninckx Lotte , Van Assche Roel , Smolders Arne , Depuydt Geert , Billen Johan , Braeckman Bart P. , Schoofs Liliane , Temmerman Liesbet 
Published: June 2014

Significance
Recently it has been suggested that metformin, the most commonly used antidiabetic drug, might also possess general health-promoting properties. Elucidating metformin’s mode of action will vastly increase its application range and will contribute to healthy aging. We reveal a signaling cascade in which metformin is able to extend lifespan by increasing the production of reactive oxygen species (ROS). This allowed us to further work at the crossroads of human disease and aging research, identifying a key molecule that is able to translate the ROS signal into a prolongevity cue: an antioxidant peroxiredoxin is also able to activate a lifespan-promoting signaling cascade, here described in detail. Continued research efforts in this field lead toward a targeted improvement of aging-related complications.
In situ selectivity profiling and crystal structure of SML-8-73-1, an active site inhibitor of oncogenic K-Ras G12C
Authors: Hunter John C. , Gurbani Deepak , Ficarro Scott B. , Carrasco Martin A. , Lim Sang Min , Choi Hwan Geun , Xie Ting , Marto Jarrod A. , Chen Zhe , Gray Nathanael S. , Westover Kenneth D. 
Published: June 2014

Significance
SML-8-73-1 (SML) is the first example, to our knowledge, of a GTP-competitive inhibitor of V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog (K-Ras). A high-resolution structure of K-Ras G12C bound to SML shows K-Ras in an inactive conformation. In situ proteomic-based chemical profiling of SML demonstrates that SML is highly selective for K-Ras G12C over other small GTPases. A novel chemosensor-based assay allows measurement of covalent reaction rates between K-Ras G12C and SML and enables characterization of this reaction in the context of millimolar concentrations of GTP and GDP, well in exccss of what is found in living cells. These results demonstrate that even in the presence of high concentrations of GTP and GDP, SML is able to exchange into the GN site.
Transcription is initiated on silent variant surface glycoprotein expression sites despite monoallelic expression in
Trypanosoma brucei
Authors: Kassem Ali , Pays Etienne , Vanhamme Luc 
Published: June 2014

Significance
African trypanosomes are a major plague in sub-Saharan Africa. They cause sleeping sickness in humans and nagana in cattle, preventing extensive cattle raising. They escape the immune system of their host through frequent changes in their major surface antigen, the variant surface glycoprotein (VSG). The control of VSG expression is poorly understood, and the level at which it takes place has been a matter of debate for the last 25 y. A better understanding of the mechanism by which it works would facilitate the identification of the proteins involved and would provide putative targets for drug design. We report data indicating an unusual control level, namely after transcription initiation, suggesting transcription elongation or RNA processing as a control step.