bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Case of Atypical Inter‐muscular Lipoma (Evans)
Authors: Kashima Masato , Saito Kazuyoshi 
Published: April 2015

AbstractA case of a 51‐year‐old woman with a lipoma‐like tumor on the right arm which showed rapid recurrence after the first simple excision is reported. On the second surgical operation, a lipoma‐like tumor with extensive growth between the biceps muscle and brachialis muscle of the right arm was noted. Histological examination revealed almost mature fat cells and scattered atypical lipoblast‐like cells. For the treatment of an atypical inter‐muscular lipoma, complete excision is necessary, although very extensive treatment is not recommended.
Eruptive Steatocystoma Multiplex on the Scalp
Authors: Kumakiri Masanobu , Yajima Chiho 
Published: April 2015

AbstractWe report a 71‐year‐old Japanese woman who noticed approximately 120 small yellowish cysts on the scalp from nine months before her first visit. An incision made into the cysts discharged oily yellow material. Biopsy of a lesion disclosed that the cysts had typical features of steatocystoma multiplex histologically. This case was a unique eruptive variety of steatocystoma multiplex on the scalp.
Squamous‐cell Carcinoma Arising in Solar Keratosis of a Leprosy Patient: Relationship with Positive Skin Smear Examination
Authors: Kikuchi Ichiro , Nogami Reiko 
Published: April 2015

AbstractA 70‐year‐old Japanese female with lepromatous leprosy developed squamous‐cell carcinoma within a long standing area showing solar keratoses on her head. Alopecia had been present at least for the preceding 34 years on her forehead and frontal area of the head, and solar keratoses had existed at least for the previous 9 years. Skin smear examination for acid‐fast bacilli which had continually been negative for the previous 2 years (during which 8 examinations were done) became positive. We assume that there may be some relationship between the onset of the tumor and the positive skin smear examination, although the exact connection remains unclarified.
Large Bullous Eruption in Patients with Ulcerative Colitis
Authors: Ishibashi Akira , Yamaji Kazufumi , Hayashi Yoshitomo , Miyahara Tohru , Niwa Hirofumi 
Published: April 2015

AbstractOligocentric large bullous eruptions in two patients with ulcerative colitis were reported.Such bullae were similar to those seen in drug‐induced coma, and those described as drug eruption due to high dose frusemide. However, neither narcotic drugs nor frusemide had been given in either case. The bullae were cured after the administration of corticosteroid and/or salazosulfapyridine with a course paralleling that of the ulcerative colitis. Thus the bullae seem to be a cutaneous manifestation of ulcerative colitis.
Differential Oxygen Sensitivities in G6PDH Activities of Cultured Keloid and Normal Skin Dermis Single Cells
Authors: Sit Kwok Hung , Lau Yeow Kok , Aw Swee Eng 
Published: April 2015

AbstractCell cultures of excised keloids and biopsied normal skin were established from patients of the Plastic Surgery Department of Singapore General Hospital and their single cells quantitated for glucose‐6‐phosphate dehydrogenase (G6PDH) activity using microspectrophometry. G6PDH has been cited as a transformation‐linked discriminant. Analysis of variance shows no difference in overall activity between skin and keloid cells, but under oxygen saturation conditions, keloid G6PDH activity was significantly higher than skin G6PDH activity, although they were almost identical under nitrogen saturation conditions. Differential oxygen sensitivity in G6PDH activities between malignant and non‐malignant cells have been reported, but its occurrence between keloid and normal skin cells is novel, especially as the keloid is regarded as a benign tumor with a zero carcinogenicity rate.
Clinical Evaluation of Cutaneous Malignant Melanoma with Histologically Involved Lymph Node Metastases
Authors: Sugihara Tsuneki , Yoshida Tetsunori , Ohura Takehiko , Ohkawara Akira , Kumakiri Masanobu 
Published: April 2015

AbstractThirty‐six cases of cutaneous malignant melanoma with histologically involved lymph nodes were studied during a 2–10 year study period, and the characteristics of the metastasized nodes and the associated prognosis were compared. The results were as follows: 1) the survival rate in cases with 3 or fewer (n=16) metastasized nodes was significantly higher than in cases with 4 or more positive nodes (n=20); 2) the survival rate in cases in which metastasized nodes were limited to one regional lymph node section (n=12) was significantly higher than in cases where metastasis extended to two or more intra‐regional sections of nodes (n=24); 3) cases which had nodes measuring 3.00 cm or less (n=25) had significantly higher survival rates than those with nodes of 3.01 cm or more (n=11). Therefore, the results indicate that the number of metastasized lymph nodes, the extension into regional lymph node sections, and the size of the metastasized lymph node(s) can be considered as important prognostic factors for melanoma patients.
Transepidermal Elimination of Thrombi in Three Cases of Thrombotic Angiokeratoma: An Incidental Histopathologic Finding of Angiokeratoma
Authors: Bang Dongsik , Choi Young‐sik , Song Min Seok 
Published: April 2015

AbstractTransepidermal elimination (TEE) is a well known phenomenon by which foreign or altered constituents are removed from the dermis. A thrombosis in the dilated dermal blood vessels of angiokeratoma is not unusual, hence the term thrombotic angiokeratoma.We recently reviewed the histopathologic findings of previously diagnosed cases of angiokeratoma and found that multiple histologic sections of surgical biopsy materials disclosed changes indicating TEE of thrombi in three cases. Special stains searching for an altered substance in those thrombi failed.In this report of three cases, we suggest that this phenomenon could be an incidental and long missed histopathologic finding of angiokeratoma which might explain the fate of these thrombi.
A Case of Erythropoietic Protoporphyria with Severe Liver Dysfunction Suggesting a Close Relationship between Erythrocyte Protoporphyrin Levels and Those of γ‐GTP
Authors: Watanabe Masahisa , Ohgami Taro , Nonaka Shigeo , Yoshida Hikotaro , Tanaka Masakazu 
Published: April 2015

AbstractA case of erythropoietic protoporphyria (EPP) with severe acute abdominal pain and jaundice was reported. Erythrocyte protoporphyrin (PP) levels were constantly high, and liver histology showed a slight fibrosis with inflammatory infiltation. During the investigation period of 18 months, erythrocyte PP levels closely paralleled those of serum γ‐GTP.
Characterization of the Lymphoproliferative Diseases in the Skin by DNA Analysis
Authors: Nakajima Naoko , Tanaka Toshihiro , Miyachi Yoshiki , Imamura Sadao , Kakizuka Akira 
Published: April 2015

AbstractVarious samples from lymphoproliferative diseases in the skin were analyzed by Southern blotting technique with probes from the T cell receptor gene, immunoglobulin genes, and human T cell leukemia virus‐I genome. Samples were taken from 10 mycosis fungoides (MF) patients, 1 parapsoriasis en plaque patient, 10 Adult T cell leukemia/lymphoma (ATL) patients, 1 cutaneous T cell lymphoma (CTCL) patient, 4 lymphomatoid papulosis (LP) patients, 4 B cell lymphoma patients, and 2 actinic reticuloid (AR) patients. In MF, the monoclonality of the T cells became detectable first in the skin when plaques develop to tumors then in lymph nodes, and finally in the blood lymphocytes, indicating this disease develops from local (skin) malignancy to systemic malignancy. In parapsoriasis en plaque, no monoclonality was detected in any sample. We could distinguish cutaneous ATL from the carrier state by detecting the T cell monoclonality and HTLV‐I integration with these probes. One patient with CTCL showed detectable T cell monoclonality; 1 out of 4 patients with LP did the same. Four samples from patients with B cell lymphoma revealed detectable monoclonal rearrangement of immunoglobulin heavy and light chain genes. In AR, no monoclonality was detected in any sample. From these data, we conclude that DNA analysis is useful in determining the monoclonality, cell origin, and distribution of monoclonal cells from skin samples.
Dinitrochlorobenzene Treatment of Verrucae Plana
Authors: Shah Kirtikant C. , Patel Raksha M. , Umrigar Dipak D. 
Published: April 2015

AbstractIn a purely clinical, unbiased study, 50 patients with verrucae plana were treated with dinitrochlorobenzene for 1–24 weeks, keeping half the lesions as controls. The results were statistically insignificant when the treated patients were compared to the control group.
Annular Elastolytic Giant Cell Granuloma: An Unusual Case with Papular Lesions
Authors: Kato Hideyuki , Kitajima Yasuo , Yaoita Hideo 
Published: April 2015

AbstractA 63‐year‐old Japanese woman with multiple annular lesions on the bilateral abdomen developed numerous papules on the upper part of the back and forearms.A skin biopsy specimen taken from a papule showed the findings of annular elastolytic giant cell granuloma.
Two Cases of Diaper Area Granuloma of the Adult
Authors: Fujita Mayumi , Ohno Sayoko , Danno Kiichiro , Miyachi Yoshiki 
Published: April 2015

AbstractTwo cases of diaper area granuloma are reported.Patient 1, a 34‐year‐old man, had multiple reddish‐purple nodules over the diaper area of the right part of the genitocrural region. Candida albicans was not detected from the lesion. Histological examination of the nodule showed acanthosis and dense infiltrates. The granulomas became smaller and flatter after the control of urination.Patient 2, a 28‐year‐old man, had two large decubitus lesions and multiple nodules over the diaper area of the gluteal region. The decubitus became smaller and the granulomas disappeared after the lesion was kept clean.Because these granulomas resemble granuloma gluteale infantum, but occurred in adults rather than in the aged or infants, we propose to call this condition “granuloma gluteale adultorum.”We suggest that these granulomas may represent an inflammatory reaction to the irritation of urine or feces. It is, therefore, of great importance to treat and prevent this condition by controling the flow of urine and keeping the region clean.
Confluent and Reticulated Papillomatosis: A Clinical, Histopathological, and Electron Microscopic Study
Authors: Lee Seung Hun , Choi Eung Ho , Lee Won Soo , Kang Won Hyoung , Bang Dongsik 
Published: April 2015

AbstractThe clinical, histopathological, and electron microscopic features often patients with confluent and reticulated papillomatosis (CRP) of Gougerot and Carteaud were studied. Histopathologically, hyperkeratosis, decreased granular layer, irregular papillomatosis, and hypermelanosis of the basal layer were present. In an electron microscopic study, we found transitional cells between the stratum granulosum and stratum corneum that were increased in CRP. This finding supported the suggestion that this is a defect of keratinization.
Cutaneous Reaction Induced by Retained Bee Stinger
Authors: Hur Won , Ahn Sung Ku , Lee Seung Hun , Kang Won Hyoung 
Published: April 2015

AbstractThe clinical features and histopathologic findings of a 54‐year‐old Korean male who had retained the sting apparatus of a bee for four months are described. The clinical features showed ulcerative, erythematous plaques with irregular borders which resembled cutaneous neoplasms such as squamous cell carcinoma. Histopathologic findings included epidermal necrosis and marked pseudoepitheliomatous hyperplasia. In the dermis, the stick‐shaped sting apparatus of the bee was demonstrated and intense lymphohistiocytic and eosinophilic infiltrations were noted.
Acute Dacryocystitis Resembling an Infected Subcutaneous Cystic Tumor
Authors: Sawada Yukimasa , Nomura Kazuo 
Published: April 2015

AbstractTwo cases of acute dacryocystitis are described. Both cases manifested as a painful cystic tumor which enlarged suddenly with swelling of the involved cheek. The condition was quite similar to an infected epidermal cyst. The location of the tumor and an episode of epiphora are the characteristic features of this disease.
Comparative Study of Ki‐67 Immunostaining and Nuclear DNA Content in Histiofibrous Tumors
Authors: Ooe Mariko , Nogita Toshitatsu , Kawashima Makoto 
Published: April 2015

AbstractA comparative assessment was made of dermatofibroma, dermatofibrosarcoma protuberans, and malignant fibrous histiocytoma. The study was comprised of an immunohistochemical investigation using the Ki‐67 monoclonal antibody and a quantitative analysis of cell nuclear DNA using flow cytometry. It was found that the index of Ki‐67 monoclonal antibody labeling, the histogram pattern, and DNA index correlated with clinical malignancy, suggesting the usefulness of these indices for differential diagnosis and evaluation of prognosis.
Common Histopathological Processes of Phenytoin Drug Eruption
Authors: Tone Takeshi , Nishioka Kiyoshi , Kameyama Kouichirou , Asai Toshiya , Takezaki Shinichirou , Nishiyama Shigeo 
Published: April 2015

AbstractFifteen patients (6 males and 9 females) with phenytoin drug eruptions which ultimately resulted in various skin manifestations were analyzed histopathologically. The following types of skin manifestations were noted; 2 cases of toxic epidermal necrolysis, 2 cases of mucocutaneous occular syndrome, 6 cases of erythema exudative multiform, 3 cases of lichenoid, and 2 cases of the maculopapular type. All of the biopsied specimens from these different skin manifestations exhibited some of the more common histopathological findings: 1) adhesion of the infiltrated cells to the basal layer of the epidermis, 2) cell infiltration into the epidermis, 3) vacuolation of the basal cells, 4) dyskeratotic cells in the epidermis, and epidermal necrosis.Immunohistopathological examinations in 5 typical cases with different skin manifestations revealed that epidermal cells and infiltrating cells were HLA‐DR antigen positive. The infiltrating cells in the dermis consisted of almost equal numbers of CD4+ and CD8+ cells; CD8+ cells were predominant in the cells infiltrating into the epidermis. These findings suggest a possibility that the various clinical features in phenytoin drug eruptions may share some common mechanisms.
Microcystic Adnexal Carcinoma: A Case Report with Immunohistochemical and Electron Microscopical Examinations
Authors: Kato Naoko , Yasuoka Atsushi , Ueno Hiroo 
Published: April 2015

AbstractMicrocystic adnexal carcinoma (MAC) is an unusual cutaneous neoplasm comprised of pilar and sweat duct structures. We report here a 66‐year‐old Japanese woman with MAC on her left nasolabial fold with more prominent calcified keratinous cysts than ductal differentiated structures which stained positively for carcinoembryonic antigen (CFA). The clinical appearance and statistical characteristics of MAC are reported to be different from those of other adnexal tumors. Desmoplastic trichoepithelioma (DTE) is the most difficult tumor to differentiate from MAC, unless positive reactivity for CFA in differentiated ductal structures in MAC can be demonstrated. We compare the differences between the clinical, histological, immunohistochemical, and electron microscopical features of DTE and MAC. It seems probable that these differences could be explained by biological differences in the characteristics of the cells from which these tumors originate, hair follicle cells and eccrine sweat cells, respectively.
Epidermal Keratinocytes of Bullous Pemphigoid Express Intercellular Adhesion Molecule‐1 (ICAM‐1)
Authors: Karashima Tadashi , Hachisuka Hiroshi , Okubo Keiji , Sasai Yoichiro 
Published: April 2015

AbstractIntercellular adhesion molecule‐1 (ICAM‐1) is the ligand for lymphocyte function associated antigen‐1 (LFA‐1), mediating the adhesion of lymphocytes to vascular endothelium. Keratinocytes are known to express ICAM‐1 in some inflammatory dermatoses. Using an indirect immunofluorescence method, we examined the patterns of ICAM‐1 and LFA‐1 staining in bullous pemphigoid (BP) lesions and compared them to pemphigus vulgaris (PV) cases. ICAM‐1 was expressed on the cell surface and in the cytoplasm of epidermal keratinocytes at the sites of erythematous and bullous lesions of BP. LFA‐1 molecules were expressed on T cells at the basement membrane zone. In addition, HLA‐DR‐positive keratinocytes were observed in the basal layer. ICAM‐1 was not, however, expressed on epidermal keratinocytes in uninvolved skin from BP patients, PV or normal control skin. It is known that ICAM‐1 is expressed on keratinocytes at the site of lymphoid infiltration in cutaneous dermatoses and that LFA‐1‐positive T cells can bind to interferon gamma‐induced ICAM‐1‐positive keratinocytes. Our results suggest that cellular immunity involving ICAM‐1 and LFA‐1 may play a part in the pathogenesis of bullous pemphigoid.
Significance of Monocytosis in Varicella and Herpes Zoster
Authors: Tsukahara Tetsuya , Yaguchi Atsushi , Horiuchi Yasuhiro 
Published: April 2015

AbstractPercent ratios and absolute numbers of peripheral blood monocytes in patients with varicella and herpes zoster were determined and compared with those in patients with herpes simplex virus infection, measles and rubella. Monocytosis during the acute stage (p<0.01) was statistically significant in varicella and generalized and localized herpes zoster, compared with the levels in herpes simplex virus infection, measles and rubella. Absolute monocyte counts in varicella and HZ were significantly increased (p<0.02) beyond those of measles and rubella. The high % ratios of monocytes in varicella and herpes zoster during the acute stage decreased to normal ranges with cure.
Molluscum Contagiosum Occurring in an Epidermal Cyst
Authors: Park Soo Keun , Lee Jun Young , Kim Young Hwan , Kim Si‐Yong , Cho Baik Kee , Houh Won 
Published: April 2015

AbstractWe present three unusual cases of molluscum contagiosum occurring in epidermal cysts. All of them are asymptomatic, elevated, oval nodules diagnosed clinically as epidermal inclusion cyst or prurigo nodularis. Histology showed true epidermal cysts containing molluscum bodies throughout the cyst wall and some type of laminated material within the cyst itself. The lesion, in all three cases developed in the pubic area of young adult men.
Expression of Human T‐cell Lymphotropic Virus Type‐1 Gene Products in the Short‐term Cultured Skin Tissues of an Adult T‐cell Leukemia/Lymphoma Patient with Cutaneous Manifestations
Authors: Setoyama Mitsuru , Katahira Yoshihiko , Hamada Tetsu , Tashiro Masaaki , Yashiki Shinji , Tanaka Yuetsu , Tozawa Hideki , Sonoda Shunro 
Published: April 2015

AbstractAdult T‐cell leukemia/lymphoma (ATLL) is recognized as a disease etiologically associated with human T lymphotropic virus type‐1 (HTLV‐1) infection, but, neither viral replication nor specific virus antigen expression have been detected on ATLL cells distributed in organs, including skin. To examine the latent expression of HTLV‐1 in the cutaneous lesions of ATLL patients, we cultured the lesional skin tissues in vitro and applied immunofluorescence staining with mouse monoclonal antibodies Lt‐4, GIN‐14, and F10, which react with p40tax, p19 and gp21, respectively.We recognized HTLV‐1 specific antigens on clustered ATLL cells only in the deeper dermis of the skin after 24 hrs cultivation of the lesional skin tissue from an ATLL patient in RPMI‐1640 medium supplemented with 20% fetal calf serum. In the electron microscope, we observed HTLV‐1 like particles, 80–140 nm in diameter with envelope and core structures, in the same tissue specimen. These findings suggest that HTLV‐1 gene products may be expressed in the skin lesions of ATLL patients and involved in the pathogenesis of skin eruptions in cutaneous type ATLLs.To our knowledge, this is the first report that envisages the potency of intracutaneous HTLV‐1 expression in vivo.
A New Animal Model for Contact Dermatitis: The Hairless Guinea Pig
Authors: Miyauchi Hiroko , Horio Takeshi 
Published: April 2015

AbstractAllergic and irritant contact reactions were evaluated in the recently identified hairless guinea pig, Crl:IAF(HA)BR, a mutant from the Hartley strain. The cutaneous changes were observed macro‐ and microscopically. The irritant contact dermatitis was induced by croton oil, 2,4‐dinitrochlorobenzene (DNCB), or anthralin. Both hairless and hairy guinea pigs developed similar reactions to these chemicals. The density of the epidermal Langerhans cells (LC) of hairless guinea pigs was significantly higher than that in the hairy strain. Allergic contact sensitization was easily induced with DNCB. Photoallergic contact sensitization was also induced with tetrachlorosalicylanilide (TCSA) but not with tribromosalicylanilide (TBS). However, by administration of cyclophosphamide before sensitization, positive photocontact responses were seen with TBS. These results indicate that hairless guinea pigs can be used as animal models for investigation of immunologic and nonimmunologic contact reactions.
Immunohistochemical Characterization of Cellular Infiltrates in Epidermal Tumors Induced by Two‐stage and Complete Chemical Carcinogenesis in Mouse Skin
Authors: Moon Doo Chan , Nakayama Juichiro , Urabe Atsumichi , Terao Hiroshi , Kinoshita Nadao , Hori Yoshiaki 
Published: April 2015

AbstractWe investigated the population and pattern of the infiltrated cells in both benign and malignant epidermal tumors which were induced chemically with benzo(a)pyrene (B(a)P) in murine skin. In benign papillomas, which were evolved by a two stage carcinogenesis regimen, a slight to mild inflammatory infiltration around the tumors was observed, and cells infiltrating into the tumor nests were rarely seen. In carcinomas, which were produced by a complete carcinogenesis regimen, a dense inflammatory infiltration was observed around the tumor nests. The infiltrated cells were characterized as T‐lymphocytes, macrophages, and neutrophils. Natural killer (NK) cells were found around and in the tumor nests, but their number was small. Both T‐lymphocytes and macrophages were found to invade the tumor nests in squamous cell carcinoma whose duration was more than four weeks. This experimental carcinogenesis animal model allows the detailed quantitative and functional analysis of the infiltration of immunocompetent cells into epidermal tumors.
Long‐standing Dermatological Manifestations in a Patient with Chronic Heavy Metal Intoxication
Authors: Abraham Zeev , Glück Zahava , Feuerman Eleasar J. , Kinarty Amalia , Lahat Nitza 
Published: April 2015

AbstractA patient with chronic metal intoxication is described, presenting during four years after the cessation of her exposure to industrial substances, maculo‐papular eruptions with several ulcerated lesions and excoriations on her abdomen and buttocks. She also had pallor of her face, greyish‐dark discoloration of the hair, while the fingernails were brittle and sensitive. Scrupulous physical examination excluded further cutaneous involvement The immunological workup revealed both phenotypic and functional defects in cellular immunity.