bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Two-Phase Flowback Type Curve with Fracture Damage Effects for Hydraulically Fractured Reservoirs
Authors: Zhang Fengyuan , Pan Yang , Liu Chuncheng , Yang Chia-Hsin , Emami-Meybodi Hamid , Rui Zhenhua 
Published: July 2024

Summary
Type curves are a powerful tool in characterizing hydraulic fracture (HF) and reservoir properties based on flowback and production data. We propose a type-curve method to evaluate HF characteristics and their dynamics for multifractured horizontal wells (MFHWs) in hydrocarbon reservoirs using flowback production data. The type curve incorporates the HF damage effect of choked-fracture skin factor in the two-phase flow in HF and matrix domains. The type-curve method can be applied to inversely estimate choked-fracture skin factor, s, HF pore volume (PV), Vfi, and HF initial permeability, kfi, by analyzing two-phase flowback production data. By introducing the new dimensionless parameters, the nonuniqueness problem of the type-curve analysis for two-phase flow is significantly reduced by incorporating the complexity of fracture dynamics into one set of curves. The accuracy of the type curve is examined against the results obtained from numerical simulations of shale gas and oil reservoirs. The validation results demonstrate a good match of analytical type curves and numerical data plots and confirm the accuracy of the proposed method in estimating the static and dynamic fracture properties. The results show that the relative errors in Vfi, kfi, and s estimations are all &lt;10% for the simulated cases that are presented in this work. The flexibility and robustness of the proposed method are illustrated using the field example from a shale oil MFHW. The accuracy and applicability of the proposed type curve are also validated by comparing the calculated fracture properties from the field example using straightline analysis with Vfi and kfi of 705.3 Mcf and 245.2 md, type-curve analysis method (without skin effect) with Vfi and kfi of 751.9 Mcf and 249.8 md, and the type-curve method (with the choked fracture skin considered) with Vfi and kfi of 708.7 Mcf and 252.9 md, which showed that the results of each case are very close to one another. The interpreted results from the flowback analysis of the field example offer quantitative insight into HF properties and dynamics.
Smartformer: An Intelligent Transformer Compression Framework for Time-Series Modeling
Authors: Wang Xiaojian , Wang Yinan , Yang Jin , Chen Ying 
Published: July 2024

Abstract

Transformer, as one of the cutting-edge deep neural networks (DNNs), has achieved outstanding performance in time-series data analysis. However, this model usually requires massive amounts of parameters to fit. Over-parameterization not only brings storage challenges in a resource-limited setting but also inevitably results in the model over-fitting. Even though literature works introduced several ways to reduce the parameter size of Transformers, none of them addressed this over-parameterized issue by concurrently achieving the following three objectives: preserving the model architecture, maintaining the model performance, and reducing the model complexity (number of parameters). In this study, we propose an intelligent model compression framework, Smartformer, by incorporating reinforcement learning and CP-decomposition techniques to satisfy the aforementioned three objectives. In the experiment, we apply Smartformer and five baseline methods to two existing time-series Transformer models for model compression. The results demonstrate that our proposed Smartformer is the only method that consistently generates the compressed model on various scenarios by satisfying the three objectives. In particular, the Smartformer can mitigate the overfitting issue and thus improve the accuracy of the existing time-series models in all scenarios.
Transcriptome-derived networks reconstruct distinct immune strategies under different iron availability between Arabidopsis and rice
Authors: Garcia-Molina Antoni , Martín-Cardoso Héctor , Ribaya María , Segundo Blanca San , Busoms Sílvia 
Published: July 2024

Abstract

Fe, an essential element for plants to sustain central biological functions, recently emerged as a modulator of immunity. However, our understanding of the crosstalk between Fe and defence is limited. Here, we report antagonistic immune phenotypes in Arabidopsis thaliana and Oryza sativa infected by Colletotrichum higginsianum and Magnaporthe oryzae under different Fe nutritional status. Functional and topological analysis of transcriptional networks unveiled interspecific differences in complexity and hierarchy for similar biological functions, as well as in Fe usage and distribution, to articulate defence. Mechanistically, our results are consistent with a regulatory role of Fe in the biosynthesis of the defensive metabolites glucosinolates in A. thaliana (joint effect hypothesis), whereas O. sativa uses Fe to trigger oxidative stress at infection sites (metal defence). Nevertheless, common regulatory features might differently coordinate the transcriptome responses of both species. An evolutionary interpretation of divergences in the interplay between Fe and immunity is discussed.
Validation of the interdisciplinary Norwegian vision assessment tool KROSS in stroke patients submitted to hospital or rehabilitation services
Authors: Falkenberg Helle K. , Langeggen Irene , Munthe-Kaas Ragnhild , Råen Marianne , Eilertsen Grethe , Mathisen Torgeir S. 
Published: July 2024

Abstract

Introduction Identifying vision problems after stroke is important for providing appropriate referral and vison rehabilitation in the healthcare services. In Norway, vision assessment is not standard routine or integrated in stroke care, due to lack of knowledge, guidelines and validated Norwegian assessment tools for healthcare professionals (HCP) without formal vision competence. This study aimed to validate and assess reliability of the KROSS vision assessment tool for identifying vision problems in stroke patients.
Methods The KROSS tool has 21 items, including symptoms, observations and assessment of visual acuity, visual field, eye movements and visual inattention. The primary outcome is to identify if a vision problem is present. Sixty-seven stroke survivors (69.8 years, 28 females)) was assessed twice. The first KROSS assessment was by an HCP without formal vision competence and compared to a reference assessment by an optometrist/KROSS specialist within two days. Sensitivity, specificity, positive and negative predictive values (PPV/NPV) and inter-rater reliability (Gwet’s AC1/Cohen’s Kappa) were calculated with 95% confidence intervals.
Results The KROSS tool demonstrated high sensitivity (98%) and specificity (83%), with excellent reliability (AC1 >0.86/Kappa >0.83) and observer agreement (93%) for the primary outcome. A vision problem was identified in 64%, where 44% reported a vision symptom. The PPV and NPV for identifying a vision problem were 0.91 and 0.95. Sensitivity scores for visual acuity, reading, and visual inattention assessments were all excellent (>80%) and specificity scores were high for all items (>70%). Most items showed excellent/substantial agreement (AC1>0.7/kappa>0.6). The lowest agreements were for motility (AC1>0.8/kappa>0.4) and peripheral visual fields (AC1>0.8/kappa>0.5).
Conclusions This study shows that the KROSS tool shows promises as a valuable tool for integrating vision assessment into stroke health services. It has high sensitivity and specificity, and excellent reliability, indicating high accuracy for identifying a vision problem. This indicates that KROSS tool can reliably be used by HCPs without formal vision competence to identify a vision problem. The fact that many stroke survivors were identified with vision problems using the KROSS tool, even if they did not complain of visual symptoms, support the significance of including structured vision assessment in stroke care.
Efficient Combinatorial Adaptor-Mediated Targeting of Acute Myeloid Leukemia with CAR T-Cells
Authors: Manz Markus , Volta Laura , Myburgh Renier , Pellegrino Christian , Koch Christian , Maurer Monique , Manfredi Francesco , Hofstetter Mara , Kaiser Anne , Schneiter Florin , Müller Jan , Buehler Marco , De Luca Roberto , Favalli Nicholas , Magnani Chiara , Schroeder Timm , Neri Dario 
Published: July 2024

Abstract

CAR T-cell products targeting lineage-specific cell-of-origin antigens, thereby eliminating both tumor and healthy counterpart cells, are currently clinically approved therapeutics in B- and plasma-cell malignancies. While they represent a major clinical improvement, they are still limited in terms of efficacy by e.g. single, sometimes low-expressed antigen targeting, and in terms of safety by e.g. lack of on-off activity. Successful cell-of-origin non-discriminative targeting of heterogeneous hematopoietic stem and progenitor cell malignancies, such as acute myeloid leukemia (AML), will require antigen-versatile targeting and off-switching of effectors in order to then allow rescue by hematopoietic stem cell transplantation (HSCT), preventing permanent myeloablation. To address this, we developed adaptor-CAR (AdFITC-CAR) T-cells targeting fluoresceinated AML antigen-binding diabody adaptors. This platform enables the use of adaptors matching the AML-antigen-expression profile and conditional activity modulation. Combining adaptors significantly improved lysis of AML cells in vitro. In therapeutic xenogeneic mouse models, AdFITC-CAR T-cells co-administered with single diabody adaptors were as efficient as direct CAR T-cells, and combinatorial use of adaptors further enhanced therapeutic efficacy against both, cell lines and primary AML. Collectively, this study provides proof-of-concept that AdFITC-CAR T-cells and combinations of adaptors can efficiently enhance immune-targeting of AML.
Do you get what you pay for? The influence of emotional valence and scarcity on the price-quality effect
Authors: Zhao Na , Sun Yixin , Shi Minyang , Chen Yuxin 
Published: July 2024

Abstract

The impact of emotions on price-quality perceptions is not well understood. We conducted for studies to explore this relationship. The results showed that positive mood had a positive impact on the price-quality effect, while negative mood did not significantly affect the relationship (Study 1). In addition, participants primed with a positive mood relied more on price when making quality judgments than those primed with a negative mood (Studies2 and 3). We also found that the sense of scarcity moderated the relationship between emotional valence and the price-quality effect (Study 4). Specifically, positive and negative moods had different impacts on the price-quality effect only among participants with a lower sense of scarcity. These findings advance our understanding of price-quality judgments and shed light on how the sense of scarcity influences the relationship between mood and the price-quality effect.
Effect of Magnetic Auricular Acupuncture on Pain during Ophthalmic Examination of the Newborn: A Multicenter, Triple-Blinded, Randomized Controlled Study
Authors: Li Long , Tuerxun Roukeyan , Su Yajie , Yao Yanli , Yang Chuangzhong , Wang Hongyun , Wang Lili , Wu Hui , Chen Yanxiang , Liu Xiuxiang , Jiang Hong , Gao Hongxia , li Dong , Wu Fang , Shi Yuan , Li Xiaoying , Sun Huiqing , Wang Yanchen , Wang Laishuan , Lee Shoo K. 
Published: July 2024

Abstract

Introduction: Newborn ophthalmologicexamination is a painful procedure. Untreated pain experiences in infants have both short-term and long-term consequences, and pain control is essential. Unfortunately, non-pharmacological pain strategies are usually ineffective for complex and protracted procedures, whereas many pharmacologic agents have adverse effects. Magnetic auricular acupuncture (MAA) is a new method of pain relief that is potentially safe and effective. The objective of this study was to conduct a large definitive triple blinded randomized controlled trial of MAA for reducing pain in neonates undergoing ophthalmologic examination. The trial was registered at ClinicalTrials.gov (ChiCTR1900027474). The registration was completed on November 14, 2019.
Methods: This was a multi-centerrandomized controlled trial conducted at 16 tertiary hospitals in the People’s Republic of China. Infants were eligible for participation if they were born at 26 to 42 weeks gestational age (GA) and admitted to participating NICUs during the study enrollment period, and scheduled to receive an eye examination for the first time at <44 weeks’ corrected GA. Written informed consent was obtained from parents. Infants who were critically ill, dying or receiving sedatives were excluded. Infants randomized to the intervention (MAA) group receivedmagnetic stickers applied prior to the ophthalmologic procedure. Control group infants received placebo stickers with the magnets removed. We compared the primary outcome of Premature Infant Pain Profile (PIPP) score during the procedure between the two groups.
Results: A total of 408 patients were randomized, but 14 patients in each of the placebo and intervention groups did not receive ophthalmologic examination; leaving 190 patients in control group and 190 in intervention group. Infant characteristics were similar in the two groups,mean PIPP scores during eye exam were significantly lower in the intervention group compared to the control group (median (IQR): 10.00 (5.00,13.00) v 12.00 (7.00,14.00), p = 0.038).
Conclusions：MAA may offer an alternate to current non-pharmacologic and pharmacologic interventions to alleviate neonatal pain. Future studies should assess the long term outcomes.
Precise Generation of Conformational Ensembles for Intrinsically Disordered Proteins via Fine-tuned Diffusion Models
Authors: Chen Haifeng , Zhu Junjie , Li Zhengxin , Zheng Zhuoqi , Zhang Bo , Zhong Bozitao , Bai Jie , Wang Taifeng , Wei Ting , Yang Jianyi 
Published: July 2024

Abstract

Intrinsically disordered proteins (IDPs) play pivotal roles in various biological functions and are closely linked to many human diseases including cancer, diabetes and Alzheimer disease. Structural investigations of IDPs typically involve a combination of molecular dynamics (MD) simulations and experimental data to correct for intrinsic biases in simulation methods. However, these simulations are hindered by their high computational cost and a scarcity of experimental data, severely limiting their applicability. Despite the recent advancements in structure prediction for structured proteins, understanding the conformational properties of IDPs remains challenging partly due to the poor conservation of disordered protein sequences and limited experimental characterization. Here, we introduce IDPFold, a method capable of generating conformational ensembles for IDPs directly from their sequences using fine-tuned diffusion models. IDPFold bypasses the need for Multiple Sequence Alignments (MSA) or experimental data, achieving accurate predictions of ensemble properties across numerous IDPs. By sampling conformations at the backbone level, IDPFold provides more detailed structural features and more precise property estimation compared to other state-of-the-art methods. IDPFold is ready to be used in the elucidate the sequence-disorder-function paradigm of IDPs.
A comprehensive study of cellulignin production from sugarcane bagasse, sugarcane straw, and energy cane for advanced biofuels: liquor composition and cellulignin characterizations
Authors: Gonçalves Igor M. , Chaves Diego M. , Rufino Ana B. M. X. , Antunes Tales R. , Quintão Ana J. S. , Silva Renê C. da , Ferreira Sukarno O , Silva Gilmare A. da , Peternelli Luiz A. , Barbosa Márcio H. P. , Teofilo Reinaldo F 
Published: July 2024

Abstract

This work aims to comprehensively study the optimal conditions for hydrothermal pretreatment for sugarcane bagasse (SCB), sugarcane straw (SCS), and energy cane (EC). Raw SCB, SCS, and EC were submitted to hydrothermal pretreatments in a reactor at temperatures ranging from 180 to 300 oC. Aliquots of the liquor were collected over time (0 to 180 minutes). Glucose, xylose, arabinose, furfural, hydroxymethyl furfural, and acids were analyzed by high-performance liquid chromatography. The solid materials, i.e., biomass and cellulignin, were characterized using X-ray diffraction, mid-infrared, thermogravimetric analysis, and scanning electron microscopy. Best pentose and furfural yields were obtained from SCB pretreatment, reaching 98.8 g kg− 1 and 30.6 g kg− 1 at 90 min and 180 ºC, respectively. SCS reached at 170 ºC and 165 min, 60.7 g kg− 1 and 24.7 g kg− 1 of pentoses and furfural, respectively. EC provided 50.6 and 28.5 g kg− 1 of pentose and furfural, respectively, at 180 ºC and 90 min. In general, the best results were obtained at 180 ºC and 75 minutes for pentoses and values above 190 ºC and 90 min for furfural. Hydrochar was observed above 230 ºC. SCB exhibited the highest release of acetic acid, resulting in a faster rate of pentose release.
Valorization of Dairy Wastewater into microbial lipid by an oleaginous yeast Pseudozymasp. for Sustainable Biodiesel Production
Authors: Kumari Ritu , Rapelli Divya , Manuel Jerold 
Published: July 2024

Abstract

This study evaluated the potential accumulation of lipid of isolated Yeast from soil sample by using Synthetic dairy wastewater as a renewable feedstock for biodiesel production. on the basis of their lipid accumulation five oleaginous Yeast (i.e.Y1, Y2, Y5, Y6, Y7) were screened (lipid content >20%) and the productivity on a Yeast Peptone medium. The effect on capacity of lipid accumulation by different carbon sources (i.e. Galactose, Glucose, Starch, Sucrose and Cellulose) of the Yeast isolates was evaluated. The Y1 oleaginous yeast which shows closet relation to Pseudozyma genus could accumulate (54%) lipid, biomass production (2.47g/l) using Glucose and galactose as a source of carbon. Furthermore, the Y1 yeast strains demonstrated effective utilization of dairy wastewater, resulting in a substantial reduction (~50%) in Chemical Oxygen Demand (COD), along with notable lipid accumulation (49.8%) and biomass production (1.5 g/l). The lipids produced by Yeast Y1 had the presence of various fatty acid i.e. oleic acid, alpha linolenic acid etc., and presence of high percent of saturated fatty acid over total fatty acid as visually confirmed by Nile red staining and chemical characterized by nuclear magnetic resonance (NMR) spectroscopy. NMR analysis indicated that the lipids extracted from Yeast Y1 were suitable for biodiesel applications. Overall, the findings of this study underscore the potential of leveraging dairy wastewater as a cost-effective and efficient resource for biodiesel production using oleaginous yeast. This approach not only addresses contemporary concerns regarding fuel shortages, food security and climate change but also contributes to the sustainable management of wastewater resources.
Bariatric Surgery Outcomes in People with Severe Obesity (BMI ≥ 50 kg/m2)
Authors: Tan Sarah Ying Tse , Liang Trilene Ruiting , Chua Jasmine Kai Ling , Tan Hong Chang , Ho Emily Tse Lin , Kovalik Jean Paul , Eng Alvin Kim Hock , Lim Chin Hong , Tan Jeremy Tian Hui , Chan Weng Hoong , Lim Eugene Kee Wee , Foo Angelina Xiangying , Goh Orlanda Qi Mei , Lee Phong Ching 
Published: July 2024

Abstract

Introduction
The benefits of metabolic bariatric surgery (MBS) in people with body mass index (BMI) ≥50kg/m2 are not well-established, with concerns of increased risk and poorer weight loss. Optimal surgical type (gastric bypass [GB] versus sleeve gastrectomy [SG]) is unclear, with studies comparing complication rates, weight loss, and glycemic outcomes reporting mixed results.
Methods
Participants with BMI≥50kg/m2 undergoing MBS (SG or GB) from 2008-2022 were recruited. Demographics, anthropometrics, biochemistry and diabetes status were analysed at baseline, 12-months, and 24-months post-operatively. Surgical outcomes and complications were analysed.
Results
The study included n=184 with BMI≥50kg/m2 (57.6% female, age 38.6±10.5years, BMI 55.3±6.0kg/m2). Pre-operatively, 21.1% had pre-diabetes and 33.2% had diabetes (mean HbA1c 8.0±1.7%).
Most subjects (89.1%) underwent SG. The overall 30-day adverse event rate was 4.9%, higher in GB group (GB=15%, SG=3.7%, p=0.061). The GB group had longer length of stay (GB =4.5±0.6days, SG=3.1±0.2, p=0.023). The 30-day readmission rate was 2.2%, and rate of revisional surgery was 2.7%, with no significant difference between groups.
The follow-up rate was 67.9% at 12-months, 51.1% at 24-months. Average %total weight loss at 12-months (27.4±9.0%, SG=27.6±9.0%, GB=26.0±9.4%, p=0.481) and 24-months (27.1±10.9%, SG=27.4±11.1%, GB=24.9±8.9%, p=0.495) were similar between groups. The GB group had a larger HbA1c reduction (3.2±1.1%) than SG (1.9 ±1.3%, p=0.030), but no difference in diabetes remission rates (69.2% at 12-months, 76.7% at 24-months).
Conclusion
MBS is safe and effective for individuals with BMI≥50kg/m2, with good weight loss and glycemic outcomes with both SG and GB. Complication rates were low, although higher in the GB group.
Improving mental health and self-efficacy in older people through a mindfulness-based community intervention
Authors: Juraga Denis , Rukavina Tomislav , Glavić Mihaela Marinović , Roviš Darko , Bilajac Lovorka , Knežević Maša , Raat Hein , Vasiljev Vanja 
Published: July 2024

Abstract

Ageing is a process that involves biological, psychological, and social changes making older people more susceptible to decreased self-efficacy and deteriorating their mental health. With the global population ageing, there is a growing demand for interventions tailored to address their specific mental health problems and improve their overall well-being. This study aimed to assess the effectiveness of a mindfulness-based community intervention on mental health and self-efficacy in older individuals. The study involved 257 participants who were divided into an intervention and a control group. Assessments were conducted at the beginning and 6 months after its completion. The results revealed a significant reduction in depression within the intervention group (p <.001). Furthermore, the intervention led to significant improvements in general self-efficacy, chronic disease self-management self-efficacy, physical activity and nutrition self-efficacy within the intervention group compared to the control group. Overall, the results demonstrate the effectiveness of mindfulness-based community interventions in improving mental health and self-efficacy in older people in community settings. The results of the present study showed that this programme resulted in immediate health benefits in terms of mental health and self-efficacy of older people, while giving a contribution to the development of effective strategies for chronic disease self-management.