bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Evaluation of Structural Effects of Acyclic and Macrocyclic Ligands Derived from (R,R)‐Cyclohexane‐1,2‐diamine in the Enantioselective Cu(II)‐Catalyzed Henry Reaction.
Authors: Cerisoli Lucia , Grilli Stefano , Savoia Diego 
Published: April 2015

AbstractTwo new ligands with acyclic and macrocyclic structure are synthesized and tested in the Henry reaction of benzaldehyde with nitromethane.
ChemInform Abstract: NH4PF6‐Promoted Cyclodehydration of α‐Amino Carbonyl Compounds: Efficient Synthesis of Pyrrolo[3,2,1‐ij]quinoline and Indole Derivatives.
Authors: Ji Xiao‐Ming , Zhou Shu‐Juan , Deng Chen‐Liang , Chen Fan , Tang Ri‐Yuan 
Published: April 2015

AbstractTitle compounds (II), (IV), and (VI) are efficiently and conveniently synthesized by a metal‐free cyclodehydration strategy.
ChemInform Abstract: I2‐Catalyzed Regioselective Oxo‐ and Hydroxy‐Acyloxylation of Alkenes and Enol Ethers: A Facile Access to α‐Acyloxyketones, Esters, and Diol Derivatives.
Authors: Reddi Rambabu N. , Prasad Pragati K. , Sudalai Arumugam 
Published: April 2015

AbstractThe simple regioselective oxo‐acyloxylation process of alkenes and enol ethers with carboxylic acids provides α‐acyloxyketones and esters.
ChemInform Abstract: Metal‐Free Alkynylation of α‐C—H Bonds of Ethers with Ethynylbenziodoxolones.
Authors: Zhang Ruo‐Yi , Xi Long‐Yi , Zhang Lei , Liang Shuai , Chen Shan‐Yong , Yu Xiao‐Qi 
Published: April 2015

AbstractC—H bonds adjacent to an oxygen or nitrogen atom are effectively alkynylated by ethynylbenziodoxolones under mild conditions with moderate to good yields.
ChemInform Abstract: Pd‐Catalyzed Cross‐Coupling Reactions of Less Activated Alkenyl Electrophiles (for Tosylates and Mesylates) with Tosylhydrazones: Synthesis of Various 1,3‐Dienes.
Authors: Patel Poojan K. , Dalvadi Jignesh P. , Chikhalia Kishor H. 
Published: April 2015

AbstractTitle reaction results in the formation of various alkenyl derivatives.
ChemInform Abstract: Broad Scope Hydrofunctionalization of Styrene Derivatives Using Iron‐Catalyzed Hydromagnesiation.
Authors: Jones Alison S. , Paliga James F. , Greenhalgh Mark D. , Quibell Jacob M. , Steven Alan , Thomas Stephen P. 
Published: April 2015

AbstractAn operationally simple, chemo‐ and regioselective hydromagnesiation reaction generates benzylic Grignard reagents.
ChemInform Abstract: Visible‐Light‐Driven Difluoroacetamidation of Unactive Arenes and Heteroarenes by Direct C—H Functionalization at Room Temperature.
Authors: Wang Lin , Wei Xiao‐Jing , Jia Wen‐Liang , Zhong Jian‐Ji , Wu Li‐Zhu , Liu Qiang 
Published: April 2015

AbstractThe mild, scalable method tolerates a broad scope of electron‐rich and electron‐deficient aromatic and heteroaromatic systems.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling of Styrenes with Aryl Methyl Ketones in Ionic Liquids: Direct Access to Cyclopropanes.
Authors: Cotugno Pietro , Monopoli Antonio , Ciminale Francesco , Milella Antonella , Nacci Angelo 
Published: April 2015

AbstractThis method uses molten tetrabutylammonium acetate as ionic liquid.
ChemInform Abstract: Efficient and Highly Enantioselective Construction of Trifluoromethylated Quaternary Stereogenic Centers via High‐Pressure Mediated Organocatalytic Conjugate Addition of Nitromethane to β,β‐Disubstituted Enones.
Authors: Kwiatkowski Piotr , Cholewiak Agnieszka , Kasztelan Adrian 
Published: April 2015

AbstractIn comparison to previously developed methods, this high pressure procedure offers several advantages such as a much broader substrate scope, a lower loading of commercially available catalysts, shorter reaction times, and higher enantioselectivities.
ChemInform Abstract: Synthesis of γ‐Nitroaldehydes Containing Quaternary Carbon in the α‐Position Using a 4‐Oxalocrotonate Tautomerase Whole‐Cell Biocatalyst.
Authors: Radivojevic Jelena , Minovska Gordana , Senerovic Lidija , O'Connor Kevin , Jovanovic Predrag , Savic Vladimir , Tokic‐Vujosevic Zorana , Nikodinovic‐Runic Jasmina , Maslak Veselin 
Published: April 2015

AbstractThe resulting γ‐nitroaldehydes exhibit moderate antifungal activity and mild in vitro cytotoxicity against human fibroblasts.
ChemInform Abstract: Synthesis of Amides Through an Oxidative Amidation of Tetrazoles with Aldehydes under Transition‐Metal‐Free Conditions.
Authors: Du Juan , Luo Kai , Zhang Xiuli 
Published: April 2015

AbstractAmides (III) (30 examples) are efficiently synthesized by a simple, inexpensive, and environmentally friendly one‐pot procedure in good yields.
ChemInform Abstract: Synthesis of Diaryl Thioethers from Aryl Halides and Potassium Thiocyanate.
Authors: Hajipour Abdol R. , Pourkaveh Raheleh , Karimi Hirbod 
Published: April 2015

AbstractA novel Pd‐catalyzed synthesis of symmetric diaryl sulfides from aryl halides and KSCN is developed.
ChemInform Abstract: Facile‐Prepared Sulfonated Water‐Soluble PEPPSI‐Pd‐NHC Catalysts for Aerobic Aqueous Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Zhong Rui , Poethig Alexander , Feng Yinkai , Riener Korbinian , Herrmann Wolfgang A. , Kuehn Fritz E. 
Published: April 2015

AbstractThe catalyst is shown to be active for the Suzuki—Miyaura cross‐coupling reaction.
ChemInform Abstract: Pd‐ and Cu‐Catalyzed Stereo‐ and Regiocontrolled Decarboxylative/C—H Fluoroalkenylation of Heteroarenes.
Authors: Rousee Kevin , Schneider Cedric , Couve‐Bonnaire Samuel , Pannecoucke Xavier , Levacher Vincent , Hoarau Christophe 
Published: April 2015

AbstractAlkenylcopper intermediates generated from (Z)‐ and (E)‐α‐fluoroacrylic acids and CuCO3 undergo stereo‐ and regioselective Pd‐catalyzed coupling reactions with heteroarenes.
ChemInform Abstract: Copper‐Mediated/Catalyzed Oxyalkylation of Alkenes with Alkylnitriles.
Authors: Bunescu Ala , Wang Qian , Zhu Jieping 
Published: April 2015

AbstractPhthalides and isochromanones are accessible by the oxyalkylation of benzamide alkenes with alkylnitriles in the presence of stoichiometric amounts of copper salts.
ChemInform Abstract: Palladium‐N‐Heterocyclic Carbene (NHC)‐Catalyzed Asymmetric Synthesis of Indolines Through Regiodivergent C(sp3)—H Activation: Scope and DFT Study.
Authors: Katayev Dmitry , Larionov Evgeny , Nakanishi Masafumi , Besnard Celine , Kuendig E. Peter 
Published: April 2015

AbstractThe Pd‐catalyzed asymmetric cyclization reaction of substrates (I) and (IV) provides two regioisomeric products with low to excellent enantioselectivities.
ChemInform Abstract: Preparation of Ruthenium Azido Complex Containing a Tp Ligand and Ruthenium‐Catalyzed Cycloaddition of Organic Azides with Alkynes in Organic and Aqueous Media: Experimental and Computational Studies.
Authors: Wang Tsang‐Hsiu , Wu Feng‐Ling , Chiang Guan‐Ru , He Sheng‐Ting , Lo Yih‐Hsing 
Published: April 2015

AbstractNovel ruthenium complexes bearing an azido ligand are prepared and successfully applied as catalyst to the regioselective 1,3‐dipolar cycloaddition of benzyl azides to terminal alkynes.
ChemInform Abstract: Organocatalytic Morita—Baylis—Hillman/Michael/Acetalization Cascade: Procedure‐Controlled Diastereodivergence in the Asymmetric Synthesis of Fully Substituted Tetrahydropyrans.
Authors: Han Bo , Xie Xin , Huang Wei , Li Xiang , Yang Lei , Peng Cheng 
Published: April 2015

AbstractThe presented approach allows the production of two synthetically important compounds with excellent stereo control in a one‐pot operation.
ChemInform Abstract: A Facile and General Approach to 3‐((Trifluoromethyl)thio)‐4H‐chromen‐4‐one.
Authors: Xiang Haoyue , Yang Chunhao 
Published: April 2015

AbstractCompounds (I) react with active electrophilic trifluoromethylthio species generated in situ from AgSCF3 and trichlorocyanuric acid to give the title products (III).
ChemInform Abstract: Enantio‐ and Diastereoselective Access to Distant Stereocenters Embedded withinTetrahydroxanthenes: Utilizing ortho‐Quinone Methides as Reactive Intermediates in Asymmetric Broensted Acid Catalysis.
Authors: Hsiao Chien‐Chi , Liao Hsuan‐Hung , Rueping Magnus 
Published: April 2015

AbstractUsing BINOL‐derived organocatalysts NBP and TBP, cyclocondensation of cyclohexa‐1,3‐diones with 2‐hydroxybenzhydrols gives the annulated tetrahydro‐1H‐xanthen‐1‐ones in good yields with high enantioselectivity.
ChemInform Abstract: Primary Amino Acid Catalyzed Asymmetric Intramolecular Mannich Reaction for the Synthesis of 2‐Aryl‐2,3‐dihydro‐4‐quinolones.
Authors: Mondal Buddhadeb , Pan Subhas Chandra 
Published: April 2015

AbstractPrimary amino acids are found to be efficient catalysts for the direct asymmetric Mannich reaction of 2‐aminoacetoacetophenones with aldehydes furnishing 2‐aryldihydroguinolones (III) (25 examples) in moderate to good yield and good to high enantioselectivities.
ChemInform Abstract: An Expeditious and Metal‐Free Synthetic Route Towards Quinolones, Naphthyridones and Benzonaphthyridones.
Authors: Victor Napoleon John , Muraleedharan Kannoth Manheri 
Published: April 2015

AbstractThe described two‐step reaction proceeds through tandem aza‐Michael addition, SNAr cyclization followed by oxidation with IBX.
ChemInform Abstract: Direct C—H Difluoromethylenephosphonation of Arenes and Heteroarenes with Bromodifluoromethyl Phosphonate via Visible‐Light Photocatalysis.
Authors: Wang Lin , Wei Xiao‐Jing , Lei Wen‐Long , Chen Han , Wu Li‐Zhu , Liu Qiang 
Published: April 2015

AbstractThe first visible‐light‐driven difluoromethylenephosphonation of arenes and hetarenes is presented using diethyl bromodifluoromethylphosphonate as radical precursor in the presence of fac‐Ir(PPy)3 (IRP) as photocatalyst.
ChemInform Abstract: A New Method for Peptide Synthesis in the N→C Direction: Amide Assembly Through Silver‐Promoted Reaction of Thioamides.
Authors: Pourvali Aysa , Cochrane James R. , Hutton Craig A. 
Published: April 2015

AbstractN‐Protected amino acids (I) undergo an interesting Ag2CO3‐promoted coupling with amino ester thioamides to yield N‐acetylated dipeptides (III) without epimerization.
ChemInform Abstract: A D‐Ribose‐Derived α‐Amino Nitrile as a Versatile Intermediate for the Collective Synthesis of Piperidine‐Type Iminosugar C‐Glycosides.
Authors: Hu Xiang‐Guo , Daryl Ariawan A. , Hunter Luke 
Published: April 2015

AbstractTreatment of α‐amino nitrile (I) with AgBF4 generates an iminium salt intermediate, which is readily functionalized with Grignard reagents to form C‐glycoside products with excellent stereocontrol.
ChemInform Abstract: Fluevirines A—D (I)‐(III), Four New Securinega‐Type Alkaloids from Flueggea virosa.
Authors: Li Xiao‐Hui , Cao Ming‐Ming , Zhang Yu , Li Shun‐Lin , Di Ying‐Tong , Hao Xiao‐Jiang 
Published: April 2015

AbstractFluevirine A (I) exhibits weak antimicrobial activity against Staphylococcus aureus.
ChemInform Abstract: New Alkaloids Sinomacutines A—E, and cephalonine‐2‐O‐β‐d‐glucopyranoside from Rhizomes of Sinomenium Acutum.
Authors: Li Yan‐Hong , Li Hong‐Mei , Li Yan , He Juan , Deng Xu , Peng Li‐Yan , Gao Ling‐Huan , Zhao Qin‐Shi , Li Rong‐Tao , Wu Xing‐De 
Published: April 2015

AbstractCompounds (I)‐(VI) are evaluated towards their antiinflammatory and cytotoxic activity.
ChemInform Abstract: Two Novel Polycyclic Spiro Lignans from Gymnotheca involucrata.
Authors: Xiao Shi‐Ji , Lei Xin‐Xiang , Xia Bing , Xu Dan‐Qing , Xiao Hong‐Ping , Xu Hong‐Xi , Chen Fang , Ding Li‐Sheng , Zhou Yan 
Published: April 2015

AbstractEvaluation of the antiviral activity of gymnothespirolignans A (I) and (II) reveals promising activities.
Crystallin Nanofibrils: A Functionalizable Nanoscaffold with Broad Applications Manufactured from Waste
Authors: Kaur Manmeet , Roberts Sarah , Healy Jackie , Domigan Laura , Vasudevamurthy Madhusudan , Gerrard Juliet A. , Sasso Luigi 
Published: April 2015

AbstractProtein nanofibrils self‐assembled from crystallin proteins, a waste material from the fishing industry, have been identified as a suitable material to be used as a bionanoscaffold. In this study, a successful method for the functionalization of crystallin protein nanofibrils by immobilizing several enzymes of industrial relevance (glucose oxidase, β‐galactosidase, pectinase, α‐amylase, and laccase) through a glutaraldehyde cross‐linking approach is reported. The extent of functionalization is evaluated by using gel electrophoresis, transmission electron microscopy, and thermostability studies. The functionalized fibrils are investigated further for reusability studies—the use of protein nanofibrils as nanoscaffolds results in a significant increase in enzyme thermostability and reusability relative to the free enzyme in solution under the same conditions. Finally, as an example and proof of concept, the use of the developed functionalization method in a biosensor platform for glucose and lactose detection is shown, by utilizing the crystallin protein nanofibrils as nanoscaffolds.
Fluorescence triggering: A general strategy for enumerating and phenotyping extracellular vesicles by flow cytometry
Authors: Arraud Nicolas , Gounou Céline , Turpin Delphine , Brisson Alain R. 
Published: April 2015

AbstractPlasma contains cell‐derived extracellular vesicles (EVs) which participate in various physiopathological processes and have potential biomedical applications. Despite intense research activity, knowledge on EVs is limited mainly due to the difficulty of isolating and characterizing sub‐micrometer particles like EVs. We have recently reported that a simple flow cytometry (FCM) approach based on triggering the detection on a fluorescence signal enabled the detection of 50× more Annexin‐A5 binding EVs (Anx5+ EVs) in plasma than the conventional FCM approach based on light scattering triggering. Here, we present the application of the fluorescence triggering approach to the enumeration and phenotyping of EVs from platelet free plasma (PFP), focusing on CD41+ and CD235a+ EVs, as well as their sub‐populations which bind or do not bind Anx5. Higher EV concentrations were detected by fluorescence triggering as compared to light scattering triggering, namely 40× for Anx5+ EVs, 75× for CD41+ EVs, and 15× for CD235a+ EVs. We found that about 30% of Anx5+ EVs were of platelet origin while only 3% of them were of erythrocyte origin. In addition, a majority of EVs from platelet and erythrocyte origin do not expose PS, in contrast to the classical theory of EV formation. Furthermore, the same PFP samples were analyzed fresh and after freeze‐thawing, showing that freeze‐thawing processes induce an increase, of about 35%, in the amount of Anx5+ EVs, while the other EV phenotypes remain unchanged. The method of EV detection and phenotyping by fluorescence triggering is simple, sensitive and reliable. We foresee that its application to EV studies will improve our understanding on the formation mechanisms and functions of EVs in health and disease and help the development of EV‐based biomarkers. © 2015 International Society for Advancement of Cytometry
Monomeric or Dimeric Aluminum Complexes as Catalysts for Cycloaddition between CO2 and Epoxides
Authors: Kim So Han , Han Sang Yeop , Kim Jeong Hee , Kang Yi Young , Lee Junseong , Kim Youngjo 
Published: April 2015

AbstractA monomeric aluminum complex containing aliphatic tetradentate ligand L1 (HOCMe2CH2NMeCH2CH2NMeCH2CMe2OH) was synthesized and used as a catalyst for cycloaddition between CO2 and epoxides in the presence of PPNCl as a cocatalyst. To check the effect of ligand L1, coordinated to the aluminum center, on the activity of cycloaddition, the new ligand HOCMe2CH2NMe2, which corresponds to half of L1, was systematically designed to make monomeric or dimeric aluminum complexes. Comparison of the catalytic properties of the aluminum complex containing the tetradentate ligand with those of the two related aluminum complexes containing the bidentate ligand under the same conditions revealed that the first system showed higher activity than the other two for cycloaddition between CO2 and epoxides in the presence of PPNCl, which was the best cocatalyst out of the six compounds nBu4PBr, nBu4NCl, nBu4NBr, nBu4NI, DMAP, and PPNCl.
Superior Performance of a MoS2‐RGO Composite and a Borocarbonitride in the Electrochemical Detection of Dopamine, Uric Acid and Adenine
Authors: Pramoda K. , Moses Kota , Maitra Urmimala , Rao C. N. R. 
Published: April 2015

AbstractA MoS2‐RGO composite and borocarbonitride (BC5N) have been used as electrodes to selectively detect dopamine and uric acid in the presence of ascorbic acid. Both the electrodes show excellent eletrocatalytic activity towards the detection of dopamine, the detection limits being 0.55 μM and 2.1 μM in the case of MoS2‐RGO and BCN respectively. MoS2‐RGO shows a linear range of current over the 1–110 μM concentrations of dopamine, while BCN shows over the 2.3–20 μM range. BCN also exhibits satisfactory performance in the oxidation of uric acid with a detection limit of 3.8 μM and the linear range from 4 to 40 μM. The MoS2‐RGO has also been used to detect adenine as well.
High‐Speed Fabrication of Lithium‐Ion Battery Electrodes by UV‐Curing
Authors: Xue Zheng , Hu Libo , Amine Khalil , Zhang Zhengcheng 
Published: April 2015

AbstractIn this study, UV‐curing was investigated as an alternative method to provide fast production of composite cathodes and significantly reduce the time and energy required for solvent removal in lithium‐ion battery fabrication. To serve our purpose, low‐molecular‐weight polysiloxane acrylate (PSA) was designed and synthesized from a polysiloxane epoxide precursor. In the presence of the acrylic acid additive LiNi1/3Mn1/3Co1/3O2 (NMC), electrode laminates containing 10 wt % PSA binder were successfully fabricated by UV‐curing. The cured electrode exhibited good mechanical and electrochemical properties. At current rates up to C/3, the cell performance of the UV‐cured NMC electrode was comparable to that of conventional polyvinylidene fluoride (PVDF)‐bound NMC electrode. Our initial success in applying high‐speed UV‐curing in composite electrode fabrication has proved that it is a promising route to substantially reducing the capital and operation costs of lithium‐ion battery electrode manufacturing and additionally bringing about important environmental benefits.
Well‐balanced positivity preserving central‐upwind scheme for the shallow water system with friction terms
Authors: Chertock A. , Cui S. , Kurganov A. , Wu T. 
Published: April 2015

SummaryShallow water models are widely used to describe and study free‐surface water flow. While in some practical applications the bottom friction does not have much influence on the solutions, there are still many applications, where the bottom friction is important. In particular, the friction terms will play a significant role when the depth of the water is very small. In this paper, we study shallow water equations with friction terms and develop a semi‐discrete second‐order central‐upwind scheme that is capable of exactly preserving physically relevant steady states and maintaining the positivity of the water depth. The presence of the friction terms increases the level of complexity in numerical simulations as the underlying semi‐discrete system becomes stiff when the water depth is small. We therefore implement an efficient semi‐implicit Runge‐Kutta time integration method that sustains the well‐balanced and sign preserving properties of the semi‐discrete scheme. We test the designed method on a number of one‐dimensional and two‐dimensional examples that demonstrate robustness and high resolution of the proposed numerical approach. The data in the last numerical example correspond to the laboratory experiments reported in [L. Cea, M. Garrido, and J. Puertas, Journal of Hydrology, 382 (2010), pp. 88–102], designed to mimic the rain water drainage in urban areas containing houses. Since the rain water depth is typically several orders of magnitude smaller than the height of the houses, we develop a special technique, which helps to achieve a remarkable agreement between the numerical and experimental results. Copyright © 2015 John Wiley & Sons, Ltd.
Novel value‐added uses for sweet potato juice and flour in polyphenol‐ and protein‐enriched functional food ingredients
Authors: Grace Mary H. , Truong An N. , Truong Van‐Den , Raskin Ilya , Lila Mary Ann 
Published: April 2015

AbstractBlackcurrant, blueberry, and muscadine grape juices were efficiently sorbed, concentrated, and stabilized into dry granular ingredient matrices which combined anti‐inflammatory and antioxidant fruit polyphenols with sweet potato functional constituents (carotenoids, vitamins, polyphenols, fibers). Total phenolics were highest in blackcurrant‐orange sweet potato ingredient matrices (34.03 mg/g), and lowest in muscadine grape‐yellow sweet potato matrices (10.56 mg/g). Similarly, anthocyanins were most concentrated in blackcurrant‐fortified orange and yellow sweet potato matrices (5.40 and 6.54 mg/g, respectively). Alternatively, other protein‐rich edible matrices (defatted soy flour, light roasted peanut flour, and rice protein concentrate) efficiently captured polyphenols (6.09–9.46 mg/g) and anthocyanins (0.77–1.27 mg/g) from purple‐fleshed sweet potato juice, with comparable efficiency. Antioxidant activity correlated well with total phenolic content. All formulated ingredient matrices stabilized and preserved polyphenols for up to 24 weeks, even when stored at 37°C. Complexation with juice‐derived polyphenols did not significantly alter protein or carbohydrate profiles of the matrices. Sensory evaluation of the ingredient matrices suggested potential uses for a wide range of functional food products.
The Nature of Selected English Teachers' Online Participation
Authors: Rodesiler Luke 
Published: April 2015

AbstractThis article documents an investigation into the nature of selected secondary English teachers’ online participation across platforms (i.e., blogs, microblogs, social networking sites) as they explored issues related to teaching, learning, and literacy. Ethnographic content analysis of online artifacts generated over approximately 10 months revealed four interrelated participatory practices that reflect the nature of the teachers’ online participation: supporting teachers, seeking support, curating ideas and information, and promoting one's own online content. With implications for teacher education and future research, the study contributes to growing understandings of teachers’ efforts to advance their professional development by participating online.
Impaired aquaporins expression in the gastrointestinal tract of rat after mercury exposure
Authors: Bottino Cinzia , Vázquez Marta , Devesa Vicenta , Laforenza Umberto 
Published: April 2015

AbstractThe main route of exposure to mercury in humans is through the diet. Consequently, the gastrointestinal mucosa is exposed to the mercurial forms, where they cause intestinal fluid accumulation, mucosal injuries and diarrhea. The relationship between inorganic mercury (HgCl2) and methylmercury (CH3HgCl) exposure and water movement in the gastrointestinal tract is still unexplored. The leading role of aquaporins (AQPs) in the rapid bidirectional movement of fluid in the gastrointestinal tract of mammals is well established. The present study evaluates the effect of HgCl2 and CH3HgCl exposure on AQP expression in different portions of the gastrointestinal tract of rats treated by gavage (5 mg kg–1 of mercury species, single dose, 4 days). The results show that mercury species reduce mRNA and protein levels of AQPs in different parts of the gastrointestinal tract. In the stomach, treated rats show a significant reduction of expression of AQP3 (80–90% for mRNA and 50% for protein) and AQP4 (95–99% for mRNA and 20–40% for protein). In the small and large intestine, treated rats experience a significant reduction of AQP3 and AQP7 expression. Protein contents of both AQPs are reduced in similar proportions in jejunum (AQP3: 40–50%; AQP7: 45–50%) and colon (AQP3: 35–40%; AQP7: 45–60%), regardless of the treatment. Our results indicate that some AQPs are downregulated in the rat gastrointestinal tract by mercury exposure, suggesting a possible role of AQPs in the development of mercury gastrointestinal symptoms. Copyright © 2015 John Wiley & Sons, Ltd.