bluuebunny/crossref_metadata_2025_split huggingface dataset:
Investigation into the curative potential of dietary vitamin c supplementation on atrazine toxicity: behaviour and growth performance of <i>Clarias gariepinus</i> Juveniles (Burchell, 1822)
Authors: Opute P.E. , Inojie E. 
Published: August 2024

Atrazine is one of the most widely used pesticides in Nigeria. Several studies have shown the toxic effects of this herbicide on aquatic organisms, such as fish. Thus, it is critical to identify mitigation options to protect the health of fish, particularly commercially important aquaculture species exposed to atrazine from agricultural runoffs. -1 This study investigated the toxic effects of 10, 20, and 30 µg L of atrazine on the behaviour and growth performance of Clarias gariepinus juveniles and the curative potentials of dietary Vitamin C supplementation. The fish samples were taken weekly from different tanks to determine the specific growth rate, condition factor, and behavioural pattern following sub-chronic exposure to atrazine. The exposed fish groups showed a significant decrease (p < 0.05) in their specific growth rate (SGR) and condition factor with increasing concentrations of atrazine. Atrazine exposure also resulted in behavioural anomalies, including erratic swimming, clinging to the water surface, loss of equilibrium, lethargy, and skin discolouration. Co-exposure with Vitamin C did not significantly improve the growth performance or ameliorate the observed behavioural impairments. Therefore, findings from this study indicate that atrazine interferes with the behaviour and growth performance of C. gariepinus juveniles. However, the antioxidant property of Vitamin C supplementation in the fish diet did not significantly mitigate the toxicity of atrazine in the exposed fish.
Production of β-fructofuranosidase from<i>Aspergillus flavus</i> IBK-02 using orange peel as a low-cost substrate: Optimization through response surface methodology
Authors: Oyedeji O. , Bamigbade O.O. , Oluduro O.A. , Mokoena M.P , Olaniran A.O. 
Published: August 2024

β-fructofuranosidases have wide applications in diverse industrial sectors such as the food, confectionary, and pharmaceutical industries. This study was aimed at the optimization of β-fructofuranosidase production from a filamentous fungus, under submerged fermentation condition, using orange peel as a low-cost substrate. Fungi were isolated from decaying orange fruit and screened for β- fructofuranosidase production. The fungal strain with the most appreciable enzyme production was identified as Aspergillus flavus IBK-02 by the sequencing of the internal transcribed spacer region of the ribosomal DNA. β-fructofuranosidase production from the selected fungus was optimized using the conventional one-at-a-time approach by studying the effect of each of the medium parameters incubation period, carbon sources, nitrogen sources, pH, and temperature on the enzyme production. Also, the influence of four independent parameters (initial pH, temperature, inoculum concentration, and orange peel concentration) on β-fructofuranosidase production was studied using the Box 2 Behnken Design (BBD) of response surface methodology (RSM). The coefficient of determination (R ) obtained was 0.9600 showing that the quadratic model used for the prediction was significant (P>0.05). At the end of the experiment, the optimal levels of the four significant variables (initial pH, temperature, inoculum concentration, and orange peel concentration) were 6, 35 oC, 2.0% v/v, and 2% w/v, respectively, which produced 122.48 U/mL β-fructofuranosidase. The enzyme production increased by about 5-fold in the optimum fermentation medium condition by RSM compared with the medium optimized through the onefactor-at-a- time approach. This study has revealed that the statistical process development for the production of β-fructofuranosidase from A. flavus IBK-02, using orange peel as a low-cost substrate, could be used for industrial and biotechnological applications.
Radiological risk assessment in drinking water: evaluation of radon concentrations in Ondo town, southwestern Nigeria
Authors: Olufemi A.P. , Adebayo A.S. , Olagunju E.O. , Ogunlana F.O. , Babatunde O.A. , Olowookere C.J. 
Published: August 2024

Radon exposure is a significant public health risk, accounting for 3-14% of all lung cancer cases. Radon exposure is the second biggest cause of lung cancer in smokers and the first among nonsmokers. This study evaluates radon concentrations and assesses the annual effective doses of radon via ingestion and inhalation in drinking water sources in Ondo town. For this purpose, forty samples of groundwater used for drinking were analyzed for radon concentration using RAD7 alpha spectrometry. Activity concentrations of radon in Ondo town ranges from 0.41 to 5.57 Bql-1 with an average value of 1.94 Bql-1 . The mean concentration of radon is -1 substantially lower than the United State Environmental Protection Agency suggested limit of 11.1 Bql-1 . The annually effective dosage for ingestion for infants (10.28 µSvy ), children (3.78 µSvy ) and adults (4.96 µSvy ) and inhalation (0.005 µSvy ) were below the action level value of 0.1 mSvy suggested by World Health -1 Organization and 3-10 mSvy proposed by the International Commission on Radiological Protection (ICRP). The data and results from this study could serve as a guide for future policies guiding the development, operation, and preservation of groundwater resources in the investigated region.
The effect of two fertilizer types on growth, yield, gluten content of two Cameroon wheat landraces
Authors: Lendzemo E. Tatah , Mofor L. Nyagarlouh , Tabi Kingsley Mbi , Abwe M. Ngone , Tange D. Achiri , Njualem D. Khumbah 
Published: August 2024

Wheat (Triticum aestivum) is one of the most important cereals in the world, providing 20% of calories in the daily diets of the world. Wheat is highly consumed in Cameroon directly or processed into bread and biscuits. However, the need to increase quality wheat production in Cameroon is emphasized especially in the wake of the geopolitical crisis between Ukraine and Russia. This study was designed to ascertain the impact of two nitrogen sources (urea and Ammonium sulphate) at different doses (0g, 2g, 4g and 6g) per plant on growth, yield and gluten content of two Cameroon landraces of wheat (Boyo and Adamawa). In April 2022, a split plot experiment with landrace as main plots and fertilizer doses as subplots was established in the research field of the Regional College of Agriculture Bambili, North West Region of Cameroon. Plant height did not vary across fertilizer doses but Boyo was significantly taller than Adamawa (P < 0.05). The number of leaves and the number of tillers progressively increased with fertilizer doses. The number of spikes increased with increased fertilizer doses and the values for Boyo were higher than those for Adamawa for corresponding doses. Interaction effects of variety x dose was significant (F = 7.162, df = 3, 40, P = 0.001) on the number of grains with Boyo and Adamawa landraces producing 331 and 320 grains per plant, respectively from 6g of urea. Boyo and Adamawa produced 337 and 449, from 6g and 4g of ammonium sulphate respectively. Grain weight and gluten content increased with increase doses of fertilizers with the highest grain weight and gluten content from Adamawa landrace at 6g of ammonium sulphate per plant. The Adamawa landrace at 6g per plant of ammonium sulphate is recommended for increased yield and gluten. Other ramifications are discussed.
A disparate and complex care pathway: assessments and impact on the quality of life of endometriosis patients
Authors: Guillemot Cassandra , Klinkenberg Josephine , Sordes Florence 
Published: August 2024

Endometriosis is a complex, multifactorial disease with differential symptomatology, resulting in a long and tedious course of treatment where diagnostic erraticism reaches seven years. The often insufficiently coordinated management leads to a heterogeneous and non-optimal care pathway with a plurality of management and real therapeutic relationships. What about the reality of patients facing their doctor? Psychological processes that can explain quality of life and emotional experience will be examined in the light of Bruchon-Schweitzer's multifactorial integrative transactional model. For this purpose, a sample of 635 women aged 18 to 56 years completed a self-administered questionnaire assessing anxietydepressive symptomatology (HAD), shared decision making inherent in their care (SDM-Q9), body image (BIS) and quality of life (SF-36). Sociodemographic and biomedical questions were also asked. The results show that the participants took an average of 9.5 years to be diagnosed (SD = 6.8), and before that, 86.2% of them considered that their symptoms were of little or no importance to doctors. Today, 26.7% of them consider that they are not included in treatment decisions. This last variable is central since it is linked to levels of physical and mental quality of life and satisfaction with care. These findings lead us to think about a partnership between patients and doctors, with the aim of improving care.
L'endométriose est une maladie complexe, multifactorielle avec une symptomatologie différentielle, duquel découle un parcours long et fastidieux où l’errance diagnostique atteint en moyenne sept ans. Les soins y sont souvent insuffisamment coordonnés et conduisent à un parcours de soin hétérogène et non optimal avec une pluralité de propositions et relations thérapeutiques bien réelles. La qualité de vie peut être affectée au regard du parcours de soin et du vécu émotionnel résultant. Un échantillon de 635 femmes de 18 à 56 ans a répondu à des questionnaires auto-administrés évaluant la symptomatologieanxio-dépressive (HAD), la prise de décision partagée inhérente à leur parcours de soin (SDM-Q9), l’image corporelle (BIS) ainsi que la qualité de vie (SF-36). Des questions sociodémographiques et biomédicales ont également été posées. Les résultats mettent en évidence que les participantes ont mis en moyenne 9,5 ans avant d’être diagnostiquées (ET = 6,8), 86,2 % d’entre elles considéraient que les médecins n’accordaient pas ou peu d’importance à leurs symptômes. Elles sont aujourd’hui 26,7 % à considérer n’être pas intégrées aux décisions thérapeutiques. Cette dernière variable est centrale puisqu’en lien avec les niveaux de qualité de vie physique et mentale et la satisfaction de leurs propositions de soin. Ces constats nous amènent à réfléchir à un partenariat entre les patients et les médecins, dans le but d’améliorer la prise en soin.
Awarding a medicine family thesis prize in partnership with patients partners : an experience of partnership approach
Authors: Flora Luigi , Casta Céline , Munck Stéphane , Fauré Stéphanie , Gasperini Fabrice , Rubinstein Sébastien , Darmon David , Ravot Marielle , Bouchez Tiphanie 
Published: August 2024

This article describes how the procedures for awarding a thesis prize in family medicine were reorganized in a participatory approach in partnership with patients and training supervisors, in line with a social responsibility approach. It describes the initial procedures, how and why the selection process was modified, and discusses the contributions and issues that this has raised, before concluding with one of the results: the durability of this new way of awarding the thesis prize, a way of recognizing the quality of research carried out in family medicine theses and potentially of making this type of work more visible.
Cet article présente comment les modalités d’attribution d’un prix de thèse en médecine générale se sont réorganisées de manière participative en partenariat avec des patients et des maîtres de stages en concordance avec une orientation de responsabilité sociale. Il y est décrit les modalités initiales, en quoi et comment le processus de sélection a été modifié, et une mise en discussion des apports et des questions que cela révèle avant de conclure sur un des résultats, la pérennité acquise de cette nouvelle forme d’attribution du prix de thèse, une modalité de reconnaissance de la qualité de recherches menées en thèse de médecine générale et potentiellement d’une meilleure lisibilité de ce type de travaux.
The Effect of Competence, Individual Characteristics and Locus Of Control On Employee Performance At The Secretariat Of Pariaman City DPRD
Authors: Rofika Rofika , Susanti Febsri 
Published: August 2024

This study aims to determine the influence of competence, individual characteristics and the lacus of control partially and simultaneously on employee performance at the Pariaman City DPRD secretariat. Samples were selected using the total sampling method. The sample in this study was 40 employees of the Pariaman City DPRD Secretariat. Data collection techniques using questionnaires, while data analysis methods use validity and reliability tests, classical assumptions, multiple linear regression analysis and statistical tests (t test, F test and coefficient of determination). The results showed that the competency variables affected employee performance at the Pariaman City DPRD secretariat, with a calculated value of 3.739 > ttable 2.021 at a significant level of 0.001 < 0.05. So it can be concluded that H1 was accepted, the results of the study showed that individual characteristic variables affect the performance of employees at the Pariaman City DPRD secretariat, with a calculated value of 3.577 > ttable 2.021 at a significant level of 0.001 < 0.05
A systematic review on the effectiveness of case-based learning (CBL) in the undergraduate pharmacy programme
Authors: Zainal Zainol Akbar , Jee Lucas Kwang Hei , Abdul Hakeem Waheedah 
Published: August 2024

Background: Efforts to innovate teaching methods have led to case-based learning (CBL) as a response to traditional lecture limitations. CBL, also known as case study teaching, involves students actively achieving learning objectives with facilitator guidance. Based on literature search, no systematic review has evaluated studies on CBL effectiveness in pharmacy curricula.
Objective: This systematic review was performed to assess CBL's impact on student satisfaction, knowledge acquisition, and lecturers' perspectives for undergraduate pharmacy students.
Methods: A research question was developed for the review using the PICO framework. Keywords and synonyms were used in Boolean searches within PubMed and ERIC databases. Inclusion criteria encompassed full-text articles from 2011 to 2021, focused on undergraduate pharmacy education, and published in English. Retrieved articles were screened and analysed using ATLAS.ti 9.0 for coding and conceptual framework generation.
Results: Twelve studies were included, all assessing knowledge gain, student satisfaction, general perception, and lecturers' perspectives on CBL. Consensus indicated CBL is particularly suited for case-heavy subjects like clinical or primary care settings.
Conclusion: CBL is an effective teaching-learning method for certain subjects and should be integrated into the curriculum of undergraduate pharmacy.
INTERVENÇÕES PRÉVIAS À FERTILIZAÇÃO IN VITRO EM MULHERES COM ENDOMETRIOSE
Authors: De Oliveira Rodrigues Estela , Campolina Gomes Ana Luiza , Decker Renan Victor , Guedes Dutra Maciel Mayara 
Published: August 2024

A fertilização in vitro (FIV) é um meio de reprodução humana assistida que permite homens e mulheres com problemas de fertilidade a alcançarem uma gestação. Em mulheres com endometriose, onde a infertilidade é uma queixa frequente, a FIV é uma das alternativas para aquelas que desejam uma gestação. Objetivos: analisar os benefícios e malefícios da realização de intervenções médicas antes da fertilização in vitro em mulheres com endometriose. Metodologia: Após o auxílio da inteligência artificial para a definição do tema, a pesquisa foi realizada através dos seguintes descritores “Endometriosis”, “in vitro fertilization” e “Infertility” junto ao booleano AND, nas plataformas de dados PubMed, SciELO e Lilacs, limitando os artigos aos anos de 2019 a 2023. Após aplicar os critérios de inclusão e exclusão, foram analisados 7 artigos. Resultados e discussões: A análise dos estudos incluíram resultados satisfatórios ao uso de medicações associadas e à intervenção cirúrgica prévia. Medicamentos isolados requerem prosseguir pesquisa. Conclusão: O uso combinado de intervenção cirúrgica e farmacológica mostrou-se superior ao procedimento direto da fertilização. O uso isolado de progesterona necessita maior investimento científico para análise dos resultados; a administração de GnRH-a ou G-CSF não apresentou conclusão satisfatória.
Evaluation of Acute Toxicity of Ethanolic Extract from Fruit of Cyanometra cauliflora in ICR Mice
Authors: Somsap On-Anong , Payanglee Kolip , Kamnate Anussara , Singdam Patcharin 
Published: August 2024

This research aims to investigate the acute toxicity profile of the ethanolic extract derived from Cyanometra cauliflora fruit, a plant commonly found in Southeast Asia. Male ICR mice were divided into 5 groups and administered varying oral doses of C. cauliflora extract: 100, 200 and 400 mg/kg body weight. Subsequently, the effects on both histological and biochemical parameters were meticulously examined post-experimentation. The results indicated no significant alterations in blood glucose or blood urea nitrogen (BUN) levels attributable to C. cauliflora extract administration. Nevertheless, a noteworthy elevation in creatinine, aspartate transaminase (AST), and alkaline phosphatase (ALP) levels was observed across all groups treated with C. cauliflora extract in comparison to controls (p < 0.05). Intriguingly, the extract consistently elicited a reduction in triglyceride levels across all administered doses, while cholesterol levels exhibited a decline specifically at the 400 mg/kg body weight dose. Notably, the levels of low-density lipoprotein (LDL) and high-density lipoprotein (HDL) remained unaltered throughout the experimentation. Histological assay suggested signs of hepatocellular damage, portal dilation and infiltration of inflammatory cells across all C. cauliflora-treated groups, alongside indications of kidney atrophy and other abnormalities.
These findings collectively suggest structural and functional modifications induced by C. cauliflora extract. In summary, while the administration of C. cauliflora extract did not exert significant changes in blood glucose and BUN levels, it did lead to heightened levels of creatinine and liver enzyme markers. Furthermore, liver and kidney damage were discerned at doses ranging from 100 to 400 mg/kg body weight, underscoring the imperative need to optimize extract concentrations to mitigate potential cytotoxic effects. These findings can be further explored to understand the processes behind the observed effects and to assess potential therapeutic applications or safety considerations associated with the use of C. cauliflora extract in clinical settings.
HIGHLIGHTS

A hepatic and renal toxicity profile was detected in the ethanolic fruit extract of Cyanometra cauliflora, despite the absence of fatalities.
The ethanolic fruit extract of cauliflora L. lowered cholesterol and triglyceride levels.
Prolonged ingestion could be detrimental.

GRAPHICAL ABSTRACT
Penerapan Metode Forward Chaining pada Sistem Pakar Diagnosa Penyakit Tanaman Kelapa Sawit
Authors: Dewi Sri 
Published: August 2024

Sitem Pakar adalah sistem berbasis komputer yang dirancang untuk dapat meniru keahlian seorang pakar dalam memecahkan masalah. Metode yang digunakan dalam perancangan sistem pakar ini adalah metode Forward Chaining. Metode Forward Chaining merupakan suatu metode penalaran yang dimulai dari fakta untuk mendapatkan kesimpulan. metode Forward Chaining digunakan dalam sistem pakai ini sehingga dapat mendiagnosa penyakit tanaman kelapa sawit dan dapat memberikan solusi serta cara pengendalian penyakit tanaman kelapa sawit yang terserang penyakit berdasarkan gejala-gejala yang dipilih oleh user. Ada 5 jenis penyakit tanaman kelapa sawit dan 19 gejala penyakit tanaman kelapa sawit dengan 11 rule yang diterapkan dalam sistem pakar yang dirancang. Hasil prosedur ini akan menghasilkan fakta - fakta penyakit tanaman kelapa sawit dan solusi yang ditawarkan sistem untuk selanjutnya dilakukan penanganan pada tanaman kelapa sawit.
Meningkatkan Kemampuan Berfikir Kritis Melalui Model Pembelajaran Team Games Turnament
Authors: Robi’ah  , Kurniawan Sugeng , Wiseza Fitria Carli 
Published: August 2024

Penelitian ini bertujuan untuk meningkatkan kemampuan berpikir kritis siswa melalui model pembelajaran team games tournament pada tema praja muda karana kelas III Sekolah Dasar Negeri Nomor 145/II Tanjung Menanti Kecamatan Bathin II Babeko Kabupaten Bungo, dengan jumlah siswa sebanyak 25 orang. jenis penelitian ini adalah penelitian tindakan kelas, dengan menggunakan model kemmis dan taggart, dengan prosedur penelitian terdiri dari II siklus dengan 4 x pertemuan. Setiap siklus terdiri dari 4 tahapan perencanaan, tindakan dan pengamatan, serta refleksi. Berdasarkan hasil pengamatan dilapangan, masih ada beberapa siswa yang tidak mau bertanya, sebagian besar siswa tidak bisa menjawab pertanyaan guru, sebagian besar siswa belum bisa menyimpulkan pelajaran, tingkat penguasaan siswa terhadap materi pelajaran aku anggota pramuka masih rendah. Hasil pengamatan pembelajaran dengan menerapkan model Team Games Tournament dari pra siklus yaitu 49,40 % dengan kategori sangat kurang, meningkat pada siklus I menjadi 70,4% kategori cukup, kemudian meningkat pada siklus II menjadi 87,10% kategori baik, dan penelitian ini dikatakan berhasil, karena kemampuan berpikir kritis siswa mengalami peningkatan.
Optimisation of Some Conditions for the Biodegradation of Low-Density Polyethylene Strips by Fungi Isolated from Parts of North Central Nigeria
Authors: Chinwe Joan ogu  , Makwin Danladi Makut  , Ngozika F. Okey-Ndeche  
Published: August 2024

Abstract: Some optimum conditions (Incubation time, pH and Temperature) were studied for selected fungal isolates – Aspergillus flavus, Aspergillus niger, Fusarium chlamydosporium, Trichoderma sp. Mucour indicus, Rhizopus miehei, Basidobolus ranarum, and Microsporum nanum, to biodegrade low-density polyethylene (LDPE) waste by using Mineral Salts Medium (MSM) containing 0.500g LDPE strips (1cm by 5cm each) using changes in pH of the media and weight loss of the strips as indicators for ability of these microorganisms to degrade LDPE. The results revealed that four of the eight fungal isolates, Aspergillus flavus, Aspergillus niger, Fusarium chlamydosporium and Trichoderma sp. showed high ability to degrade the LDPE strips after 8 weeks of incubation in Mineral Salts Medium at pH7.05 and 30oC. There was noticeable variation in pH of the media with time of incubation with the highest change recorded for Aspergillus flavus (3.00±0.01), Aspergillus niger (3.02±0.01) and Rhizopus miehei (3.10±0.01) when compared with the control (without fungi) which remained at PH 7.05±0.02 during the 8-week incubation period. The weight loss of the LDPE recorded for Aspergillus flavus was 19.40±0.14 %, Aspergillus niger 19.40±0.18%, Fusarium chlamydosporium, 12.60±0.10% and 10.60±0.02% for Trichoderma sp. respectively. The weight loss of the LDPE strips was time dependent with the highest weight loss recorded after 8 weeks for all isolates. The optimum pH of 7.5 was recorded for LDPE degradation by Aspergillus flavus, Aspergillus niger, Fusarium chlamydosporium and Basidobolus ranarum while optimum pH of 6.5 was recorded for Trichoderma sp., Mucour indicus, Rhizopus miehei and Microsporum nanum. All the fungal isolates showed optimum LDPE degradation activity at 34oC except Fusarium chlamydosporium, Trichoderma sp., Mucour indicus and Rhizopus miehei which optimized activity at 32oC.