bluuebunny/crossref_metadata_2025_split huggingface dataset:
Napsin A is a useful marker for metastatic adenocarcinomas of pulmonary origin
Authors: Kim Moon‐Young , Go Heounjeong , Koh Jaemoon , Lee Kyoungbun , Min Hye‐Sook , Kim Min‐A , Jeon Yoon Kyung , Lee Hye‐Seung , Moon Kyung‐Chul , Park So Yeon , Kim Woo‐Ho , Chung Doo Hyun 
Published: January 2014

AimsTo address whether napsin A is useful for identifying metastatic adenocarcinomas of pulmonary origin.Methods and resultsFifty‐four cases of adenocarcinoma that metastasized from the lungs to various sites and 1762 cases of carcinoma from various organs were immunostained for napsin A, TTF‐1, CK7, CK20 and CDX2 using tissue microarray. The expression patterns of napsin A and TTF‐1 in metastatic pulmonary adenocarcinomas were compared with matched primary lung tumours. Napsin A and TTF‐1 were expressed in 87.0% and 81.5% of the metastatic pulmonary adenocarcinomas, respectively. Although there was no significant difference in the positivity of napsin A and TTF‐1 as a single marker in metastatic pulmonary adenocarcinomas, the expression scores for napsin A were much higher than those for TTF‐1 (P < 0.001). Moreover, the positivity and expression scores of napsin A in primary pulmonary adenocarcinomas were maintained in metastatic adenocarcinomas better than TTF‐1. Most non‐pulmonary adenocarcinomas were negative for napsin A, except for renal cell carcinomas (13.4%), ovarian adenocarcinomas (7.1%) and uterine endometrial adenocarcinomas (14.5%). In particular, clear cell adenocarcinomas of ovary (68.8%) and uterus (66.7%) frequently expressed napsin A.ConclusionsThese data suggest that napsin A may be a useful marker for identifying metastatic adenocarcinomas of pulmonary origin in combination with TTF‐1.
Assessment of Postoperative Pain in Cats After Ovariectomy by Laparoscopy, Median Celiotomy, or Flank Laparotomy
Authors: Gauthier Olivier , Holopherne‐Doran Delphine , Gendarme Thalia , Chebroux Alexandre , Thorin Chantal , Tainturier Daniel , Bencharif Djemil 
Published: January 2014

ObjectiveTo compare postoperative pain, duration of surgery, and duration of anesthesia for 3 methods of ovariectomy in cats: (1) conventional ventral median open approach (Midline), (2) right flank approach (Flank), and (3) median 2‐portal laparoscopic procedure (Lap).Study DesignRandomized, prospective clinical trial.AnimalsHealthy, sexually intact female cats (n = 60).MethodsCats were randomly assigned to 1 of 3 groups: Midline (n = 20), Flank (20), and Lap (20) were evaluated 1, 2, 4, 6, and 12 hours after endotracheal extubation. Postoperative pain was scored using the 4A‐vet pain scale that combines a subjective numerical pain rating and objective scoring of physiologic and behavioral variables including the response to stimulation of the surgical site. Pain scores (PS) were compared between groups.ResultsThere was a significant difference in the PS between groups. PS for Midline and Flank were not significantly different but were both significantly higher compared with Lap. Depending on time, 5–20% of the cats had intense postoperative pain in both Midline and Flank groups. None of the Lap cats had intense postoperative pain.ConclusionsLaparoscopic ovariectomy, although slower, appeared less painful compared with conventional ventral midline and flank ovariectomy. Postoperative pain did not differ significantly between midline and flank groups.
Using levels of evidence to compare clinical impact from research
Authors: Ahmad Tashfeen , Chinoy Muhammad Amin , Tayyab Muhammad 
Published: January 2014

AbstractObjectivesImpact of medical institutions on clinical decision‐making globally might be estimated by the level of evidence of their research articles. The aim of this study was to compare levels of evidence of articles for Pakistan.MethodsWe compared levels of evidence of articles from Pakistan, Nigeria, Japan, and the United States (U.S.).ResultsMajority (73%) of articles in U.S. general medical journals were high levels (1–2), while majority (66% to 95%) in Japanese, Nigerian, Pakistani, and sub‐specialty U.S. journals were lower levels (3–4) (P < 0.001). The number of articles from various regions of Pakistan did not correspond to their population or number of medical colleges/universities, mainly due to the skewing effect of one institution from Karachi which contributed 38% of all high‐level articles.ConclusionsA comparison of levels of evidence of articles across institutions might reflect relative potential of clinical impact, and might be useful for institutions, policy makers, and health research planners for priority setting.
An exploration of the effects of introducing a telemonitoring system for continence assessment in a nursing home
Authors: Yu Ping , Hailey David , Fleming Richard , Traynor Victoria 
Published: January 2014

Aims and objectivesTo explore the effects of introducing a telemonitoring and care planning system for urinary continence assessment in a nursing home and adherence by care staff to urinary continence care plans.BackgroundOnly a few studies have explored the effect of introducing telemonitoring system on urinary continence care, none for older people in nursing homes.DesignPre‐ and postintervention repeated measures design.MethodsData for the study were collected from August–October 2011. Care staff were trained in the use of a telemonitoring system for continence assessment. Voiding events for each older person were recorded using the system during a 72‐hour urinary continence assessment, and the data were used to prepare an individualised care plan. After two weeks of using the new care plan, a second assessment was carried out for each older person, using the telemonitoring system.ResultsThe participants were on average 81 years old and assessed as having high care needs. The statistically significant outcomes were as follows: reduced volume of urine voided into continence aids, reduced number of prescribed toileting visits, increased number of actual toilet visits, increased number of successful toileting events and increased adherence to urinary continence care plans by staff.ConclusionsDuring a 12‐week trial, urinary continence assessment and management of older people were improved. This suggests that the introduction of a suitably designed telemonitoring system combined with staff training can improve urinary continence care.Relevance to clinical practiceThe results suggest that nursing homes can improve continence assessment and management practices by adopting an appropriately designed mobile, wireless telemonitoring system for continence assessment and providing the associated staff training programmes.
Evaluation of an individualised programme to promote self‐care in sleep‐activity in patients with coronary artery disease – a randomised intervention study
Authors: Johansson Anna , Adamson Anita , Ejdebäck Jan , Edéll‐Gustafsson Ulla 
Published: January 2014

Aims and objectivesTo evaluate the effectiveness of an individualised programme to promote self‐care in sleep‐activity in patients with coronary artery disease.BackgroundRecent scientific findings have shown that low physical exercise and stress interfere with coronary artery disease patients' sleep quality and sleep efficiency independent of gender, age and co‐morbidity.DesignA randomised pretest–post‐test control design.MethodsForty‐seven patients who had undergone a coronary revascularisation procedure and/or pharmacological treatment three to seven weeks earlier at a general hospital were randomised to either an intervention group or a control group. Data collection was carried out by questionnaires, a study‐specific sleep diary and actigraphy registration for 10 consecutive 24‐hour periods, with a follow‐up after three to four months. The intervention group underwent a nurse‐led individualised education programme to promote self‐care of sleep‐activity. Sleep habits and sleep‐related lifestyle together formed the basis for setting up individual goals together with the nurse. Individual advice on physical training, relaxation exercise and a CD‐based relaxation programme was provided by a physiotherapist. Both groups received a brochure about sleep and stress.ResultsAt a three‐ to four‐month follow‐up, the main improvements were seen in the intervention group regarding sleep quality, sleep duration and sleep efficiency in the sleep diary and sleep efficiency in actigraphy. Statistical improvements in health‐related quality of life were revealed. This was not so obvious in the control group.ConclusionsAn individualised intervention programme to promote self‐care of sleep‐activity including relaxation in patients with coronary artery disease led by a nurse may improve sleep quality. However, a longitudinal study to promote self‐care in sleep‐activity should be performed using a larger sample and multiple sites with continuous follow‐ups to determine whether any positive effects remain stable over time.Relevance to clinical practiceImplementation of a multiprofessional individualised programme to promote self‐care of sleep‐activity including relaxation based on patients' needs, supported by a healthcare team and led by nurses, is important in clinical practice.
Exenatide dosing in alpacas
Authors: Cebra C. K. , Smith C. C. , Stang B. V. , Tornquist S. J. 
Published: January 2014

In order to investigate whether exenatide could be used to stimulate glucose clearance and insulin secretion in alpacas without causing colic signs, six healthy adult alpacas were injected once a day with increasing subcutaneous doses. A follow‐up intravenous glucose injection was given to induce hyperglycemia, and serial blood samples were collected to measure plasma concentrations of glucose, insulin, triglycerides, beta‐hydroxybutyrate, and nonesterified fatty acids. The exenatide doses used were saline control (no drug), and 0.02, 0.05, or 0.1 mcg/kg injected subcutaneously. Alpacas had significantly lower plasma glucose concentrations and higher insulin concentrations on all treatment days compared with the control day, but the increase in insulin was significantly greater and lasted significantly longer when the alpacas received the two higher dosages. Two of the alpacas developed mild colic signs at the 0.05 mcg/kg dose and were not evaluated at the highest dose. Based on these findings, the 0.05 mcg/kg dose appears to offer the greatest stimulation of insulin secretion and glucose clearance without excessive risk or severity of complications.
Modeling within field variation of the compaction layer in a paddy rice field using a proximal soil sensing system
Authors: Islam M. M. , Saey T. , De Smedt P. , Van De Vijver E. , Delefortrie S. , Van Meirvenne M. 
Published: January 2014

AbstractA key characteristic of flooded paddy fields is the plough pan. This is a sub‐soil layer of greater compaction and bulk density, which restricts water losses through percolation. However, the thickness of this compacted layer can be inconsistent, with consequences such as variable percolation and leaching losses of nutrients, which therefore requires precision management of soil water. Our objective was to evaluate a methodology to model the thickness of the compacted soil layer using a non‐invasive electromagnetic induction sensor (EM38‐MK2). A 2.7 ha alluvial non‐saline paddy rice field was measured with a proximal soil sensing system using theEM38‐MK2 and the apparent electrical conductivity (ECa) of the wet paddy soil was recorded at a high‐resolution (1.0 × 0.5 m). Soil bulk density (n = 10) was measured using undisturbed soil cores, which covered locations with large and smallECavalues. At the same locations (within 1 m2) the depth of the different soil layers was determined by penetrometer. Then a fitting procedure was used to model theECa– depth response functions of theEM38‐MK2, which involved solving a system of non‐linear equations and aR2value of 0.89 was found. These predictions were evaluated using independent observations (n = 18) where aPearson correlation coefficient of 0.87 with anRMSEEvalue of 0.03 m was found. TheECameasurements allowed the detail estimation of the compacted layer thickness. The link between water percolation losses and thickness of the compacted layer was confirmed by independent observations with an inverse relationship having aPearson correlation coefficient of 0.89. This rapid, non‐invasive and cost‐effective technique offers new opportunities to measure differences in the thickness of compacted layers in water‐saturated soils. This has potential for site‐specific soil management in paddy rice fields.
Visual Evaluation of Soil Structure Under Grassland management
Authors: Cui J. , Askari M. S. , Holden N. M. 
Published: January 2014

AbstractTwenty sites representing the typical range of grass‐based beef and dairy production management intensity in Ireland were used to assess soil structural quality with the Visual Evaluation of Soil Structure (VESS) method combined with laboratory analysis. The results showed that VESS was suitable for assessing soil structural quality for grassland productivity. According to the threshold values proposed by Ball [Soil Use and Management (2007), 23, 329–337] for management intervention, all fields except one in this study were between Sq 1 and Sq 3, indicating that the typical range of management intensity does not cause undue soil damage and can be regarded as sustainable for soil structure. There was an indication that as intensification increases, temperate maritime grassland soils showed signs of degradation with respect to soil structure for maintaining grass productivity. While reseeding might solve some problems, it causes others due to the release of soil carbon. This raises the prospect that ‘sustainable intensification’ of livestock production may be limited by the health of the soil resource that supports it. Significant negative correlations between Sq and soil C content (P < 0.01) and between Sq and soil N content (P < 0.05) were observed, indicating a close relationship between soil structure and soil carbon and nitrogen.
First Complete Genome Sequence of Escherichia albertii Strain KF1, a New Potential Human Enteric Pathogen
Authors: Fiedoruk Krzysztof , Daniluk Tamara , Swiecicka Izabela , Murawska Emilia , Sciepuk Malgorzata , Leszczynska Katarzyna 
Published: January 2014

ABSTRACT

Escherichia albertii
has been recently recognized as an emerging human and bird enteric pathogen. Here, we report the first complete chromosome nucleotide sequence of a clinical isolate of
E. albertii
strain KF1, which may provide information about the pathogenic potential of this new species and the mechanisms of evolution of enteropathogenic
Escherichia
spp.
Complete Genome Sequence of Mycoplasma ovis Strain Michigan, a Hemoplasma of Sheep with Two Distinct 16S rRNA Genes
Authors: Deshuillers Pierre L. , Santos Andrea P. , do Nascimento Naíla C. , Hampel Joseph A. , Bergin Ingrid L. , Dyson Melissa C. , Messick Joanne B. 
Published: January 2014

ABSTRACT

We report the complete genome sequence of
Mycoplasma ovis
strain Michigan. Its single circular chromosome has 702,511 bp and contains 2 copies of the 16S rRNA gene, one corresponding to
M. ovis
and the other to “
Candidatus
Mycoplasma haemovis.” All housekeeping genes and the 5S-23S rRNA genes are present in single copies.
Whole-Genome Sequence Characterization of a Beak and Feather Disease Virus in a Wild Regent Parrot (
Polytelis anthopeplus monarchoides
)
Authors: Sarker Subir , Forwood Jade K. , Ghorashi Seyed A. , McLelland David , Peters Andrew , Raidal Shane R. 
Published: January 2014

ABSTRACT

The whole-genome sequence of beak and feather disease virus (BFDV) from a wild Australian regent parrot (
Polytelis anthopeplus monarchoides
) was characterized. The genome consists of 1,993 bp and has a typical stem-loop structure between open reading frame 1 (ORF1) and ORF2. This is the first evidence of BFDV infection as well as the complete genome sequence for this host species, globally.
Complete Genome Sequence of a Porcine Parvovirus Strain Isolated in Central China
Authors: Wang Lin-Qing , Wang Yan , Chen Long-Biao , Fu Peng-Fei , Chen Hong-Ying , Cui Bao-An 
Published: January 2014

ABSTRACT
We report here the complete genome sequence of the porcine parvovirus (PPV) strain J-PPV, isolated from central China. Our data, together with sequence data for PPV isolates from other regions of China, will help in understanding the epidemiology and molecular characteristics of PPV field isolates in China.
Draft Genome Sequence of Bacillus thuringiensis Strain BrMgv02-JM63, a Chitinolytic Bacterium Isolated from Oil-Contaminated Mangrove Soil in Brazil
Authors: Marcon Joelma , Taketani Rodrigo Gouvêa , Dini-Andreote Francisco , Mazzero Giulia Inocêncio , Soares Fabio Lino , Melo Itamar Soares , Azevedo João Lúcio , Andreote Fernando Dini 
Published: January 2014

ABSTRACT

Here, we report the draft genome sequence and the automatic annotation of
Bacillus thuringiensis
strain BrMgv02-JM63. This genome comprises a set of genes involved in the metabolism of chitin and
N
-acetylglucosamine utilization, thus suggesting the possible role of this strain in the cycling of organic matter in mangrove soils.
Draft Genome Sequence of the Aquatic Phosphorus-Solubilizing and -Mineralizing Bacterium
Bacillus
sp. Strain CPSM8
Authors: Maitra Nilanjan , Whitman William B. , Ayyampalayam Saravanaraj , Samanta Srikanta , Sarkar Keka , Bandopadhyay Chinmay , Aftabuddin M. , Sharma Anil P. , Manna Sanjib K. 
Published: January 2014

ABSTRACT

Bacillus
sp. strain CPSM8 is an efficient solubilizer and mineralizer of phosphorus. Here, we present the 4.39-Mb draft genome sequence of the strain, providing insight into the phosphorus-releasing genes related to productivity in aquatic habitats.
Deposit temperature of pyroclastic density currents emplaced during the El Chichón 1982 and Colima 1913 eruptions
Authors: Sulpizio Roberto , Zanella Elena , Macías José Luis , Saucedo Ricardo 
Published: January 2014

Abstract

New data on the pyroclastic density current (PDC) deposit temperature (
T
dep
) are provided for two prominent eruptions of Mexican volcanoes of the twentieth century: the 1982 eruption of El Chichón and the 1913 eruption of Colima. In spite of similar lithofacies, magma composition and pre-eruptive conditions, the
T
dep
of the PDCs from the 1982 (El Chichón) and 1913 (Colima) eruptions differ significantly, with intervals of
T
dep
of 360–420 °C and 250–330 °C, respectively. These new data emphasize that a full understanding of the physical mechanisms responsible for equilibrium temperature attainment within a pyroclastic deposit has not yet been realized. The
T
dep
measured for El Chichón PDC deposits confirm the preliminary data published elsewhere, while Colima magnetic temperatures provide different values to those published previously.

supplementary-material:

T
dep
measurements for the different sites at El Chichon volcano and Colima volcano are available at:
http://www.geolsoc.org.uk/SUP18695
.
Magma flow and palaeo-stress deduced from magnetic fabric analysis of the Álftafjörður dyke swarm: implications for shallow crustal magma transport in Icelandic volcanic systems
Authors: Eriksson P. I. , Riishuus M. S. , Elming S.-Å. 
Published: January 2014

Abstract
Neogene regional mafic dykes extending north of the Álftafjörður central volcano in east Iceland are studied to test models of dyke swarm emplacement at spreading ridges. This is accomplished by using anisotropy of magnetic susceptibility to define fossilized magma flow regimes. The imbrication of the foliation plane, defined by the minor susceptibility axis, is used as an indicator of the flow direction. Contemporaneous shear resolved on the dyke walls may modify a pure flow-induced fabric and such shear regimes are therefore retracted. The magma flow and palaeo-stress resolved on the dykes are determined in 13 of 24 dykes. The magma flow is interpreted as subhorizontal and northwards directed away from the central volcano for nine dykes, and found to be vertical in three cases. The preferentially subhorizontal magma flow in the Álftafjörður swarm suggests that dyke propagation in this type of Icelandic volcanic system originates in shallow crustal magma chambers. The regional tectonic palaeo-stress field is deduced to cause oblique spreading across the Álftafjörður dyke swarm and govern a subhorizontal dextral shear component on the dyke planes during propagation. This interpretation is not in conflict with the left-stepping en echelon trend distribution of individual dykes relative to the trend of the swarm.
Identification of Immune Factors Regulating Antitumor Immunity Using Polymeric Vaccines with Multiple Adjuvants
Authors: Ali Omar A. , Verbeke Catia , Johnson Chris , Sands R. Warren , Lewin Sarah A. , White Des , Doherty Edward , Dranoff Glenn , Mooney David J. 
Published: January 2014

Abstract
The innate cellular and molecular components required to mediate effective vaccination against weak tumor-associated antigens remain unclear. In this study, we used polymeric cancer vaccines incorporating different classes of adjuvants to induce tumor protection, to identify dendritic cell (DC) subsets and cytokines critical to this efficacy. Three-dimensional, porous polymer matrices loaded with tumor lysates and presenting distinct combinations of granulocyte macrophage colony-stimulating factor (GM-CSF) and various Toll-like receptor (TLR) agonists affected 70% to 90% prophylactic tumor protection in B16-F10 melanoma models. In aggressive, therapeutic B16 models, the vaccine systems incorporating GM-CSF in combination with P(I:C) or CpG-ODN induced the complete regression of solid tumors (≤40 mm2), resulting in 33% long-term survival. Regression analysis revealed that the numbers of vaccine-resident CD8(+) DCs, plasmacytoid DCs (pDC), along with local interleukin (IL)-12, and granulocyte colony-stimulating factor (G-CSF) concentrations correlated strongly to vaccine efficacy regardless of adjuvant type. Furthermore, vaccine studies in Batf3−/− mice revealed that CD8(+) DCs are required to affect tumor protection, as vaccines in these mice were deficient in cytotoxic T lymphocytes priming and IL-12 induction in comparison with wild-type. These studies broadly demonstrate that three-dimensional polymeric vaccines provide a potent platform for prophylactic and therapeutic protection, and can be used as a tool to identify critical components of a desired immune response. Specifically, these results suggest that CD8(+) DCs, pDCs, IL-12, and G-CSF play important roles in priming effective antitumor responses with these vaccines. Cancer Res; 74(6); 1670–81. ©2014 AACR.