bluuebunny/crossref_metadata_2025_split huggingface dataset:
Detection of tumour heterogeneity in patients with advanced, metastatic castration-resistant prostate cancer on [68Ga]Ga-/[18F]F-PSMA-11/-1007, [68Ga]Ga-FAPI-46 and 2-[18F]FDG PET/CT: a pilot study
Authors: Pabst Kim M. , Mei Riccardo , Lückerath Katharina , Hadaschik Boris A. , Kesch Claudia , Rawitzer Josefine , Kessler Lukas , Bodensieck Luisa S. , Hamacher Rainer , Pomykala Kelsey L. , Fanti Stefano , Herrmann Ken , Fendler Wolfgang P. 
Published: August 2024

Abstract
Purpose
In metastatic castration-resistant prostate cancer (mCRPC), some patients show low/absent PSMA expression in tumour lesions on positron emission tomography (PET) scans, indicating heterogeneity and heightened risk of non-response to PSMA-RLT (radioligand therapy). Imaging cancer-associated fibroblasts and glucose uptake may further characterise tumour heterogeneity in mCRPC patients. Here, we aimed to evaluate tumour heterogeneity and its potential implications for management in mCRPC patients assessed for PSMA-RLT using [68Ga]Ga-FAPI-46, 2-[18F]FDG and [68Ga]Ga-/[18F]F-PSMA-11/-1007 PET.

Material and Methods
Patients with advanced, progressive mCRPC underwent clinical [68Ga]Ga-/[18F]F-PSMA-11/-1007, 2-[18F]FDG and [68Ga]Ga-FAPI-46 PET/CT to evaluate treatment with PSMA-directed RLT. Tumour detection/semiquantitative parameters were compared on a per-lesion/-region basis. Two phenotypes were defined: Criteria for the mixed phenotype were: (a) PSMA-negative findings for lymph node metastases ≥ 2.5 cm, any solid organ metastases ≥ 1.0 cm, or bone metastases with soft tissue component ≥ 1.0 cm, (b) low [68Ga]Ga-/[18F]F-PSMA-11/-1007 uptake and/or (c) balanced tumour uptake of all radioligands. The PSMA-dominant phenotype was assigned if the criteria were not met.

Results
In ten patients, 472 lesions were detected on all imaging modalities (miTNM regions: M1b: 327 (69.3%), M1a: 95 (20.1%), N1: 26 (5.5%), M1c: 18 (3.8%), T: 5 (1.1%) and Tr: 1 (0.2%). [68Ga]Ga-/[18F]F-PSMA-11/-1007 (n = 453 (96.0%)) demonstrates the highest detection rate, followed by [68Ga]Ga-FAPI-46 (n = 268 (56.8%))/2-[18F]FDG (n = 241 (51.1%)). Semiquantitative uptake was highest for [68Ga]Ga-/[18F]F-PSMA-11/-1007 (mean SUVmax (interquartile range): 22.7 (22.5), vs. [68Ga]Ga-FAPI-46 (7.7 (3.7)) and 2-[18F]FDG (6.8 (4.7)). Seven/three patients were retrospectively assigned to the PSMA-dominant/mixed phenotype. Median overall survival was significantly longer for patients who underwent [177Lu]Lu-PSMA-617 RLT and were retrospectively assigned to the PSMA-dominant phenotype (19.7 vs. 9.3 months).

Conclusion
Through whole-body imaging, we identify considerable inter- and intra-patient heterogeneity of mCRPC and potential imaging phenotypes. Regarding uptake and tumour detection, [68Ga]Ga-/[18F]F-PSMA-11/-1007 was superior to [68Ga]Ga-FAPI-46 and 2-[18F]FDG, while the latter two were comparable. Patients who underwent [177Lu]Lu-PSMA-617 RLT based on clinical-decision making had a longer overall survival and could be assigned to the PSMA-dominant phenotype.

Graphical Abstract
Species-specific effects of light and temperature on photosynthesis and respiration among Symbiodiniaceae (Dinophyceae)
Authors: Röser Phongsathorn , Glaser Karin , Juchem Desiree , Parkinson John Everett , Voolstra Christian R. , Karsten Ulf 
Published: August 2024

AbstractCoral reefs are exposed to various environmental stressors that cause bleaching events, whereby endosymbiotic microalgae (Symbiodiniaceae) disassociate from coral hosts. Bleached corals are compromised and face mortality. The combination of high-light exposure and elevated seawater temperature often lead to coral bleaching. The physiological properties of the Symbiodiniaceae within the coral tissues contribute to the thermal tolerance of the holobiont (the host and all its symbionts). The present study aimed to investigate the effects of light and temperature stress on four Symbiodiniaceae species from three genera with respect to photosynthetic oxygen production and consumption. Under control conditions, the species displayed predominantly low-to-moderate light requirements for photosynthesis with increased photoinhibition at higher photon flux rates. After 30 days of heat acclimation at 32 °C, maximum photosynthetic activity declined in Effrenium voratum, doubled in Fugacium kawagutii, and remained unchanged in Breviolum psygmophilum. In subsequent acute heating assays, species-specific effects on maximum photosynthetic activity were observed. Photosynthesis in all species declined across a temperature gradient between 25 and 39 °C in the acute heating assays; full inhibition occurred at 37 °C in B. psygmophilum and E. voratum and at 39 °C in B. aenigmaticum and F. kawagutii. In contrast, respiration remained largely constant in all species across temperatures. Our data point to species-specific photophysiological traits that lead to different thermal tolerances among Symbiodiniaceae.
Regression of Chiari malformation type 2 following early postnatal meningomyelocele repair—a retrospective observation from an institutional series of patients
Authors: Frič Radek , Beyer Mona Kristiansen , Due-Tønnessen Bernt Johan 
Published: August 2024

Abstract
Purpose
Spontaneous regression of Chiari malformation type 2 (CM2) is observed rarely, as CM2 is associated with meningomyelocele (MMC) that is surgically repaired either pre- or early postnatally. While the radiological regression of CM2 occurs frequently following prenatal repair of MMC, it has been reported in only a few studies after postnatal repair.

Methods
From the consecutive series of children with postnatally repaired MMC, we reviewed the clinical and radiological data regarding CM2, particularly its regression either spontaneously or following CSF diversion.

Results
Eighteen children underwent postnatal repair of MMC between February 2011 and April 2023. CM2 was present in 16 (89%), and hydrocephalus in 15 children (83%), requiring shunting in 14 of them. During the mean clinical observation time (from birth to April 2023) of 59 ± 51 months, three children with CM2 (19%) underwent 1–2 foramen magnum decompressions (FMD), five children (28%) 1–4 surgical untethering procedures and 13 children with shunted hydrocephalus (93%) 1–5 shunt revisions. Out of sixteen children with CM2, we observed regression of CM2 on MRI in only one case (6%) during the mean radiological follow-up (from birth to the last MRI taken) of 49 ± 51 months.

Conclusion
In our experience, spontaneous regression of CM2 in children with postnatally repaired MMC occurs quite rarely. Pathophysiological mechanisms behind the development of CM2 in children with MMC remain unclear, but our observation supports the hypothesis of an association between the downward displacement of the hindbrain and the low intraspinal pressure secondary to CSF leakage in children born with MMC.
PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease
Authors: Schröder Sophie , Fuchs Ulrike , Gisa Verena , Pena Tonatiuh , Krüger Dennis M. , Hempel Nina , Burkhardt Susanne , Salinas Gabriela , Schütz Anna-Lena , Delalle Ivana , Sananbenesi Farahnaz , Fischer Andre 
Published: August 2024

AbstractAstrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological conditions, deregulation of astrocytes contributes to neurodegenerative diseases such as Alzheimer’s disease (AD). While most research in this field has focused on protein-coding genes, non-coding RNAs, particularly long non-coding RNAs (lncRNAs), have emerged as significant regulatory molecules. In this study, we identified the lncRNA PRDM16-DT as highly enriched in the human brain, where it is almost exclusively expressed in astrocytes. PRDM16-DT and its murine homolog, Prdm16os, are downregulated in the brains of AD patients and in AD models. In line with this, knockdown of PRDM16-DT and Prdm16os revealed its critical role in maintaining astrocyte homeostasis and supporting neuronal function by regulating genes essential for glutamate uptake, lactate release, and neuronal spine density through interactions with the RE1-Silencing Transcription factor (Rest) and Polycomb Repressive Complex 2 (PRC2). Notably, CRISPR-mediated overexpression of Prdm16os mitigated functional deficits in astrocytes induced by stimuli linked to AD pathogenesis. These findings underscore the importance of PRDM16-DT in astrocyte function and its potential as a novel therapeutic target for neurodegenerative disorders characterized by astrocyte dysfunction.
Prognostic factors for tube feeding in type I SMA patients treated with disease-modifying therapies: a cohort study
Authors: Pane Marika , Stanca Giulia , Coratti Giorgia , D’ Amico Adele , Sansone Valeria Ada , Berti Beatrice , Fanelli Lavinia , Albamonte Emilio , Ausili Cefaro Carolina , Cerchiari Antonella , Catteruccia Michela , De Sanctis Roberto , Leone Daniela , Palermo Concetta , Buchignani Bianca , Onesimo Roberta , Kuczynska Eliza Maria , Tosi Michele , Pera Maria Carmela , Bravetti Chiara , Tiziano Francesco Danilo , Bertini Enrico , Mercuri Eugenio 
Published: August 2024

AbstractThe aim of this study was to assess the need for tube feeding in a cohort of treated infants with type I SMA and to identify predictive factors. All patients were classified at baseline, when treatment started, and at follow-up according to their functional level and the need for tube feeding. Fisher’s exact test was used to examine the associations between the outcome at the last follow-up and SMA type, SMN2 copy number, and baseline nutritional status. ANOVA was performed to compare CHOP INTEND scores and age at treatment initiation with outcomes. The cohort includes 75 type I SMA infants treated between 0.1 and 5 years of age. At the last follow-up, 34 had no need for tube feeding, 9 had tube feeding but were also able to be fed by mouth, and 32 had tube feeding and were unable to be fed by mouth. Thirty of the 41 infants with tube feeding at follow-up already had feeding difficulties when treatment was started. The need for tube feeding at follow-up was associated with the level of feeding involvement at baseline and with CHOP INTEND scores [p < 0.001] but not with SMN2 copy number, SMA type 1 subtypes or age at treatment. The results of this study suggest that the need for tube feeding is not frequent in treated infants with type I SMA and, when occurring, can be predicted by the level of feeding involvement and low CHOP INTEND scores at baseline.

What is Known:• The advent of disease-modifying therapies is increasingly changing the approach to swallowing and nutritional management in type I SMA.• Clinical trials and real-world data using all three disease-modifying therapies report a rather wide variability of feeding outcome and need for tube feeding that is often related to different cohorts that makes comparison between studies very difficult.

What is New:• The real-world findings of this study, including all the children treated since treatments became available, confirmed that the need for tube feeding is not an invariable finding.• The level of feeding involvement at baseline appears to be a reliable prognostic indicator of bulbar outcome.• The results highlight the need for interventional studies with structured Speech and Language Therapist protocols that will help to better understand the extent to which bulbar function can be maintained or regained even in children requiring tube feeding.
Elective splenectomy for hematological diseases: a vanishing indication
Authors: Fernández-Ananin Sonia , Novelli Silvana , Cambeiro Cabré Lorena , Vila Riera Cecilia , Ballester Vàzquez Eulalia , Julià Verdaguer Elisabet , Targarona Eduardo M. 
Published: August 2024

Abstract
Introduction
Splenectomy has been used as a diagnostic and therapeutic tool in the management of hematological diseases for many years. However, the emergence of new medical therapies has modified guidelines for many hematological diseases for which splenectomy was previously considered. We aimed to evaluate the evidence of a decrease in the hematological indications for splenectomy and the reasons and justifications for this change.

Material and methods
We conducted a single-center, retrospective analysis of patients who underwent laparoscopic splenectomy for hematological disease between January 2010 and December 2023. Patients were classified into four groups: 1 autoimmune and hemolytic diseases (HAD), (2) lymphomas, (3) myeloproliferative diseases (MPN), and (4) other splenic diseases. We recorded the annual incidence of splenectomy and the ratio of new medical cases, demographic and clinical data and surgical outcomes.

Results
During the study period, 98 patients were referred for splenectomy. There was a significant progressive decrease in this surgical indication, particularly regarding HAD (p < 0.001). The indication for splenectomy for immune thrombocytopenic purpura (ITP) declined to zero despite an increase in the number of patients diagnosed with this disorder (p < 0.001). The pattern of decrease in AHAI and Evans syndrome was similar to that in ITP. The group of splenectomies due to lymphoma persisted consistently during the study period, as did the indication for splenectomy in the context of lymphoma treatment. Splenectomy due to massive splenomegaly secondary to MPN was indicated only in one patient. Splenectomies due to other causes were similarly distributed over the years.

Conclusions
Our findings confirm a significant decrease in the indication for elective surgery for hematological diseases, mainly regarding autoimmune disease. The surgical community and surgical departments should be aware of this situation yet maintain the skills to adopt this technique both safely and efficiently.
Generalizability and treatment with sodium-glucose co-trasporter-2 inhibitors (SGLT2i) among patients with type 2 diabetes: an assessment using an Italian primary care database
Authors: Antonazzo Ippazio Cosimo , Rozza Davide , Cortesi Paolo Angelo , Fornari Carla , Zanzottera Ferrari Elena , Paris Claire , Eteve-Pitsaer Caroline , Gnesi Marco , Mele Silvia , D’Amelio Marco , Maurizi Anna Rita , Palladino Pasquale , Mantovani Lorenzo Giovanni , Mazzaglia Giampiero 
Published: August 2024

Abstract
Aims
This study aimed to assess the proportions of type 2 diabetes (T2D) subjects meeting cardiovascular outcome trials (CVOTs) criteria for sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and estimate SGLT2i utilization, along with associated demographic and clinical characteristics, in a primary care setting.

Methods
T2D patients in Italy were selected between January 1, 2021, and December 31, 2022, from The Health Improvement Network (THIN®) database. Representativeness was determined by dividing patients meeting key inclusion criteria for four CVOTs (CANVAS, DECLARE-TIMI 58, EMPA-REG OUTCOME, VERTIS-CV) to the total T2D population. Demographic and clinical characteristics of eligible T2D subjects and SGLT2i users were compared, and logistic regression models assessed the likelihood of receiving SGLT2i.

Results
Out of 17,102 T2D patients, 8,828 met eligibility criteria for at least one CVOT. DECLARE-TIMI 58 exhibited the highest representativeness (51.1%), compared to CANVAS (21.1%), EMPA-REG OUTCOME (5.5%), and VERTIS-CV (4.9%) trials. Eligible CVOTs patients were older (74.6 vs. 68.3 years), with a longer disease duration (10.2 vs. 9.7 years), and higher established cardiovascular disease (CVD) prevalence (36.0 vs. 27.3%) compared to SGLT2i users. Less than 10% of eligible T2D patients received SGLT2i. Males (OR: 1.43; 95%CI: 1.24–1.66) were more likely to be prescribed SGLT2i than other antidiabetic drugs, while the elderly (80 + vs. 40–64 years, OR: 0.17; 95% CI: 0.14–0.22) were less likely. Eligible T2D patients with CVD reported an increased likelihood of receiving SGLT2is compared to other antidiabetics.

Conclusion
This study highlights significant variability in the proportion of T2D subjects meeting SGLT2i CVOT inclusion criteria, with DECLARE-TIMI-58 being the most represented. Low SGLT2i prescription rates in the Italian primary care setting, along with substantial demographic and clinical differences between SGLT-2i users and T2D eligible patients, emphasize the need for targeted interventions to optimize the use of these medications in primary care settings.
Unravelling the threads: understanding the interplay of Cultural values, female workforce engagement, human development index and suicide rates
Authors: Vigna Elisa , Balkom Ingrid van , Bresnahan Michaeline , Cheslack-Postava Keely , Musa George , Ryan Megan , Skokauskas Norbert , Hoven Christina , Carli Vladimir 
Published: August 2024

Abstract
Purpose
Suicide is a major public health problem across the world. Extensive research on the field shows that suicide is affected by several sociological, economic, and cultural risk factors. Over the last century, social changes have driven the reshaping of traditional gender roles, often in an uneven fashion, strongly depending on context. This study proposes updated findings on the impact that changes in traditional gender roles could have on suicide rates

Methods
It will do so by examining the correlation between female labor force participation (FLPR) and sex-specific suicide rates. Moreover, it will examine this association depending on human development (HDI) and Hofstede’s individualism index. To do so, data from 2010 to 2019 from 47 countries is collected from the WHO, ILOSTAT and UN agencies’ websites.

Results
Analysis show a significant interaction between FLPR, HDI and individualism index scores on male suicide rates (p = 0.002). There is a negative association between FLPR and male suicide rates in relatively lower HDI countries, while in very high HDI countries an increase in FLPR is correlated with an increase in male suicide rates. Similar trends but no significant interaction is observed for female suicide rates.

Conclusion
This study suggests that female participation is beneficial for male population as it reduces male suicide rates. However, this association appears to be context dependent. In countries where institutional adjustment is already established, and human development is very high, other factors might be of interest in examining the trends of suicide rates among men and women.
On an isotropic porous solid cylinder: the analytical solution and sensitivity analysis of the pressure
Authors: Asghari H. , Miller L. , Penta R. , Merodio J. 
Published: August 2024

AbstractWithin this work, we perform a sensitivity analysis to determine the influence of the material input parameters on the pressure in an isotropic porous solid cylinder. We provide a step-by-step guide to obtain the analytical solution for a porous isotropic elastic cylinder in terms of the pressure, stresses, and elastic displacement. We obtain the solution by performing a Laplace transform on the governing equations, which are those of Biot’s poroelasticity in cylindrical polar coordinates. We enforce radial boundary conditions and obtain the solution in the Laplace transformed domain before reverting back to the time domain. The sensitivity analysis is then carried out, considering only the derived pressure solution. This analysis finds that the time t, Biot’s modulus M, and Poisson’s ratio v have the highest influence on the pressure whereas the initial value of pressure P0 plays a very little role.
Urban scaling of air pollutants in Israel
Authors: Yatzkan Or , Omer Itzhak , Burg David 
Published: August 2024

AbstractCities have been shown to exhibit empirical scaling behavior where numerous variables of urban performance are allometric, like greenhouse gas emissions. Polluting emissions have negative environmental and health impacts. This paper will elucidate the empirical urban scaling of atmospheric emissions for the Israeli urban system. It has been shown that cities may be environmentally efficient with CO2 emissions that seem to be sub-linear, so large cities are more “green”. However, other reports suggest a super-linear relationship with respect to population size, so the large cities are less “green”. We report here for the first time the results of the nonlinear allometric power-law properties of multiple air pollutants, expanding the analysis to include electricity consumption and atmospheric emissions of CO2, NOx, SO2, CO, NMVOC, PM10, PM2.5, Benzene and 1,3-Butadiene together in one study in the case of Israel. They show the recurring mathematical patterns of cities similar to those reported elsewhere. Electricity usage is super-linear. Pollutant emissions of these greenhouse gases tend to exhibit significant super-linear dynamics (β > 1), though NMVOC and Benzene were linear. These results were conserved when regressing against the urban vehicle fleet size. This evidence supports the hypothesis that large cities may be less “green”. Indeed, different urban characteristics such as geography, local climate and weather conditions, population density, may also affect the pollution levels of cities. Taken together these results give evidence to the effect of urban agglomerations on the environment.
Effectiveness of a 5-week virtual reality versus traditional training on balance and flexibility in healthy adult females
Authors: Greco Gianpiero , Poli Luca , Gabriele Michele , Aidar Felipe J. , Fischetti Francesco , Patti Antonino , Cataldi Stefania 
Published: August 2024

Abstract
Purpose
This study aimed to investigate the effectiveness of a 5-week virtual reality training protocol on static and dynamic balance and flexibility compared to a traditional training protocol in healthy adult females.

Methods
Twenty-one healthy female adults (age, 49.81 ± 2.99 years) were randomly assigned into three groups: Virtual Reality (VR; n = 7) that performed a 5-week exergame training protocol; Traditional Training (TR; n = 7) that performed a specific training protocol on balance, and lower limbs and abdominal strength; and waitlist control group (CG; n = 7) that continued their daily activities without any type of structured physical activity. Static balance was assessed by the ellipse area and statokinesigram parameters (Romberg test, in the open-eye (OE) and closed-eye (CE)), dynamic balance by the star excursion balance test on the right and left leg, and flexibility by the sit and reach test.

Results
After the intervention, VR and TR groups showed a significant improvement in static and dynamic balance and flexibility (all p < 0.001) compared to the CG. Compared to TR, the VR training protocol showed greater effect sizes and was more effective in percentage terms on all measured variables, particularly for Sit and Reach (82% vs. 35%), except the OE Area (42% vs. 49%).

Conclusions
Findings suggest that both a 5-week VR training protocol and a 5-week TR protocol may significantly improve static and dynamic balance and flexibility in healthy female adults. The VR training protocol showed a greater effect size compared to the TR training protocol, although it was not statistically significant. Future randomized controlled studies with a larger sample size and longer training protocols are needed to confirm this finding.