bluuebunny/crossref_metadata_2025_split huggingface dataset:
Adolescents' perceptions of the credibility of informational content on fitness and dietary supplements: The impact of banner and native advertising
Authors: Lacko David , Machackova Hana , Slavík Lukáš 
Published: August 2024

AbstractIntroductionThe assessment of online health‐related information presents a significant challenge for today's youth. Using the Processing of Commercial Media Content (PCMC) model, we investigated the impact of advertising on the perceived credibility of informational content concerning fitness (in boys) and dietary supplements (in girls).MethodsIn a survey‐based preregistered experiment, 681 Czech adolescents (aged 13–18, 52% girls) were randomly assigned to three groups and exposed to websites with a banner ad, a native ad, or simple informational text without an ad.ResultsThe presence of ads on websites diminishes the perceived credibility of informational content. While we did not observe the difference between banner and native advertising, we found one gender‐specific difference. Specifically, boys perceive informational content linked with native ads as more credible compared to girls. Additionally, no difference was found between younger and older adolescents. Adolescents demonstrated success in identifying both types of advertisements, irrespective of their age.ConclusionsThe findings are discussed in light of individual differences and various approaches to processing online content. It appears that adolescents are accustomed to native advertising, which seamlessly integrates with traditional banner ads. Moreover, it is plausible that boys assess advertising texts more heuristically and less systematically than girls. Contrary to PCMC expectations, even younger adolescents seem to possess sufficient skills to identify the advertisements.
Prostatic Pharmacokinetic and Pharmacodynamic Analysis of Ceftazidime: Dosing Strategy for Bacterial Prostatitis
Authors: Onita Tetsushu , Nakamura Kogenta , Nishikawa Genya , Ishihara Noriyuki , Tamaki Hiroki , Yano Takahisa , Naora Kohji , Morikawa Norifumi , Ikawa Kazuro 
Published: August 2024

AbstractThis study aimed to develop a prostatic pharmacokinetic model of ceftazidime and suggest more effective dosing strategy for the bacterial prostatitis, based on a site‐specific pharmacokinetic and pharmacodynamic perspective. Subjects were prostatic hyperplasia patients prophylactically receiving a 0.5‐h infusion of 1.0 g or 2.0 g ceftazidime before transurethral resection of the prostate. Plasma and prostate samples were premeditatedly collected after the administration and the concentrations were measured by high‐performance liquid chromatography. The prostate tissue/plasma ratio in area under the drug concentration‐time curve was approximately 0.476. The prostatic population pharmacokinetic model incorporated creatinine clearance (CLcr) into ceftazidime clearance was developed, and adequately predicted prostate tissue concentrations by diagnostic scatter plots and visual predictive checks. Aiming for a bactericidal target of 70% of time above minimum inhibitory concentration (T > MIC) in prostate tissue, 2.0 g twice daily achieved ≥90% expected probability against main pathogens like Escherichia coli and Proteus species in patients regardless of renal function (CLcr = 60 and 90 mL/min). However, since the expected probability of attaining the bactericidal target of 0.5‐h infusion dosing regimen did not achieve 90% against Pseudomonas aeruginosa in patients with CLcr = 60 and 90 mL/min, 4‐h infusion dosing regimen of 2.0 g three times daily (6 g/day) might be required for empirical treatment. Based on site‐specific simulations, the present study provides more effective dosing strategy for bacterial prostatitis.
Incidence and predicting factors of inadequate bowel preparation for colonoscopy: A cross‐sectional study
Authors: Asgari Alireza , Ziamanesh Fateme , Aliasgari Ali , Sohrabpour Amir Ali 
Published: August 2024

AbstractBackground and AimAdequate bowel preparation is necessary for optimal colonoscopy. Inadequate bowel preparation results in increased costs and imprecise colonoscopy results. This study aims to determine the incidence and risk factors of inadequate bowel preparation.MethodsIn this study, 604 consecutive patients were observed prospectively who underwent colonoscopy examination. The patient's clinical and demographic data were obtained on the day of the procedure. Bowel preparation was evaluated by Boston Bowel Preparation Scale (BBPS) and was divided into two groups; adequate and inadequate. Univariate and multivariate analyses were performed.ResultsInadequate bowel preparation incidence was 17.9%. In the univariate analysis, education level (P value = 0.009), body mass index (P value = 0.03), admission type (P value = 0.038), previous history of colonoscopy (P value = 0.03), color and consistency of the last feces (P value = 0.03), diabetes (P value = 0.004), and smoking (P value = 0.03) were significantly related with the incidence of inadequate bowel preparation. While ischemic heart disease (IHD) decreased the level of inadequate bowel preparation (P value = 0.047). Multivariate analysis showed that diabetes mellitus (odds ratio [OR] = 2.18), smoking (OR = 2.10), inpatient status of admission type (OR = 3.32), last stool that was non‐watery (OR = 1.60), and ischemic heart disease (OR = 0.032) were independent factors associated with inadequate bowel preparation.ConclusionDiabetic patients, smokers, inpatients and who defecated a non‐watery and colory stool as the last defecation are at risk of inadequate bowel preparation and need more potent regimens. It is important to inform patients about preventable factors that affect bowel preparation to improve their preparation outcomes.
mRNA expression insights: Unraveling the relationship between COPD and lung cancer
Authors: Gu Zhan , Sun Jijia , Wang Lixin 
Published: August 2024

AbstractBackgroundLung cancer is a prevalent form of cancer worldwide. A possible link between lung cancer and chronic obstructive pulmonary disease (COPD) has been suggested by recent studies. The objective of our research was to analyze the mRNA expression patterns in both situations, with a specific emphasis on their biological functions and the pathways they are linked to.MethodData on COPD mRNA expression was collected from the NCBI‐GEO database, while information regarding lung cancer mRNA was acquired from The Cancer Genome Atlas database. To examine the association of COPD‐related scores in lung cancer patients, we utilized the ssGSEA algorithm for single sample gene set enrichment analysis. The possible routes were examined through the utilization of Gene Ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis. Risk models were developed using Cox and least absolute shrinkage and selection operator (LASSO) regression analyses. Moreover, a GSEA was performed to investigate significant pathways among various risk groups.ResultAfter identifying 17 genes that were differentially expressed and linked to COPD, we found that they met the criteria of having a false discovery rate < 0.05 and an absolute log2 fold change > 0.585. By utilizing the ssGSEA algorithm, it became possible to classify individuals with lung cancer into two distinct groups based on their COPD status. Consequently, a seven‐gene risk model was developed specifically for these patients. The risk score was determined by applying the given formula: risk score = AC022784.1 × 0.0423737993775888 + CRISP3 × 0.0415322046890524 + MELTF × 0.0661848418476596 + MT2P1 × 0.111843227536117 + FAM83A‐AS1 × 0.045295939710361 + ZNF506 × −0.309489953363417 + ITGA6 × 0.01813978449589. The risk model associated with COPD showed a notable connection with different immune cells found in the lung cancer sample, including macrophages of M0/M1/M2 types, hematopoietic stem cells, mast cells, NK T cells and regulatory T cells. Overexpression of crucial genes was seen to enhance cell proliferation and invasive potential in the lung cancer sample. In the lung cancer sample, it was observed that an increase in ZNF506 expression enhanced both cell proliferation and invasion.ConclusionIn conclusion, this study effectively examines the potential correlation between COPD and lung cancer. A prognostic model based on seven COPD‐associated genes demonstrated robust predictive potential in the lung cancer sample. Our analysis offers comprehensive insights for lung cancer patients.
A 6‐month randomized controlled trial for vitamin E supplementation in pediatric patients with Gaucher disease: Effect on oxidative stress, disease severity and hepatic complications
Authors: Adly Amira Abdel Moneam , Ismail Eman Abdel Rahman , Ibrahim Fatma A. , Atef Mira , El Sayed Khaled Anwar , Aly Nihal Hussien 
Published: August 2024

AbstractEnzymatic deficiency in Gaucher disease (GD) may induce oxidative stress. Vitamin E is the nature's most effective lipid‐soluble antioxidant. This prospective clinical trial assessed the oxidant‐antioxidant status in Egyptian patients with GD and the efficacy and safety and of vitamin E as an adjuvant antioxidant therapy. Forty children and adolescents with GD on stable doses of enzyme replacement therapy (ERT) were enrolled. Abdominal ultrasonography and transient elastography were performed. Malondialdehyde (MDA), vitamin E, and antioxidant enzymes (reduced glutathione [GSH], superoxide dismutase [SOD], glutathione peroxidase [GPx], and peroxiredoxin 2 [PRDX2]) were assessed. Patients were compared with 40 age‐ and sex‐matched healthy controls. Patients with GD were randomized either to receive oral vitamin E for 6 months or not. All patients with GD had significantly higher MDA levels with lower levels of vitamin E and antioxidant enzymes compared with healthy controls (p < 0.001). Vitamin E and PRDX2 were negatively correlated to severity score index (SSI), lyso GL1, and MDA. After 6 months of vitamin E supplementation, SSI and liver and spleen volumes and liver stiffness were significantly lower. Lyso GL1 and MDA were significantly decreased post‐vitamin E therapy while antioxidant enzymes were significantly higher compared with baseline levels and with patients without vitamin E therapy. Oxidative stress is related to disease severity in pediatric patients with GD. A 6‐month vitamin E supplementation for those patients represents a safe therapeutic adjuvant agent increasing the efficacy of ERT, reducing oxidative stress, and improving outcomes.
SARS‐CoV‐2 reinfection broadens the antibody responses and promotes the phenotypic differentiation of virus‐specific memory T cells in adolescents
Authors: Zhao Xin‐Jing , Liu Xiao‐Lin , Gu Hong‐Jing , Liu Ti , Li De‐Yu , Zhang Sheng , Wu Jie , Du Kai‐Ge , Tian Shen , Chen Jin‐Jin , Xu Qiang , Lv Chen‐Long , Jiang Bao‐Gui , Wang Hui , Kou Zeng‐Qiang , Wang Guo‐Lin , Fang Li‐Qun 
Published: August 2024

AbstractThe emergence of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) Omicron subvariants raises concerns regarding the effectiveness of immunity acquired from previous Omicron subvariants breakthrough infections (BTIs) or reinfections (RIs) against the current circulating Omicron subvariants. In this study, we prospectively investigate the dynamic changes of virus‐specific antibody and T cell responses among 77 adolescents following Omicron BA.2.3 BTI with or without subsequent Omicron BA.5 RI. Notably, the neutralizing antibodies (NAbs) titers against various detected SARS‐CoV‐2 variants, especially the emerging Omicron CH.1.1, XBB.1.5, XBB.1.16, EG.5.1, and JN.1 subvariants, exhibited a significant decrease along the time. A lower level of IgG and NAbs titers post‐BTI was found to be closely associated with subsequent RI. Elevated NAbs levels and shortened antigenic distances were observed following Omicron BA.5 RI. Robust T cell responses against both Omicron BA.2‐ and CH.1.1‐spike peptides were observed at each point visited. The exposure to Omicron BA.5 promoted phenotypic differentiation of virus‐specific memory T cells, even among the non‐seroconversion adolescents. Therefore, updated vaccines are needed to provide effective protection against newly emerging SARS‐CoV‐2 variants among adolescents.
Unravelling the atmospheric dynamics involved in flash drought development over Spain
Authors: Noguera Iván , Domínguez‐Castro Fernando , Vicente‐Serrano Sergio M. , García‐Herrera Ricardo , Garrido‐Pérez José M. , Trigo Ricardo M. , Sousa Pedro M. 
Published: August 2024

AbstractFlash droughts (FDs) are distinguished by a rapid development associated with strong precipitation deficits and/or increases in atmospheric evaporative demand in the short‐term, but little is known about the atmospheric conditions underlying these events. In this study, we analyse for the first time the atmospheric dynamics involved in the development of FDs in Spain over the period 1961–2018. FDs are related to large‐scale atmospheric circulation patterns affecting the region, in particular with the positive phase of the North Atlantic Oscillation (NAO). The NAO is the main atmospheric driver of FDs in winter and autumn, and it is essential in explaining FD development in spring. We also found that FDs are typically linked to strong positive anomalies in 500 hPa geopotential height and sea level pressure over the region during the weeks prior to the onset. At the synoptic scale, the most common weather types (WTs) recorded during the development of FDs are Anticyclonic Western (ANT_W_AD), East (E_AD) and Northeast (NE_AD) advection, and Anticyclonic (ANTICYC). In particular, ANTICYC WT is the main atmospheric driver of FDs in summer. Ridging conditions occur frequently during FDs in all seasons, being the most important factor controlling FD development in spring. Likewise, we noted that some of the FDs recorded in summer are related to and/or exacerbated by Saharan air intrusions associated with pronounced ridges. The results of this research have important implications for the understanding, monitoring and prediction of FDs in Spain, providing a detailed assessment of the main atmospheric dynamics involved in FD triggering at different spatial scales.
Modulation of Pacific decadal oscillation on the relationship between El Niño–Southern Oscillation and rainy season onset over the Indo‐China Peninsula
Authors: Wang Fen , Luo Xian , Li Siyu , Wu Xinqu 
Published: August 2024

AbstractMonsoon precipitation variability over the Indo‐China Peninsula (ICP) has become more complicated affected by global warming. In this study, the modulation of Pacific decadal oscillation (PDO) on the relationship between El Niño–Southern Oscillation (ENSO) and the rainy season onset over the ICP were investigated. The results showed that the ICP rainy season onset were predominantly correlated with winter sea surface temperature anomalies (SSTAs) in the East Pacific Ocean, with late and early onsets following El Niño and La Niña events, respectively. During the warm and cold PDO phase, the correlations tended to be substantially strengthened and weakened, respectively. Further analysis indicates that PDO significantly influenced the effects of ENSO on the ICP rainy season onset by modulating SSTAs and low‐level wind fields. During the El Niño events, abnormal easterlies over the Bay of Bengal (BoB) and southern ICP suppressed water vapour transporting to the ICP, which may be related to the zonal SST anomaly gradient between the Indian Ocean and the Northwest Pacific Ocean. When the El Niño occurred during the warm PDO phase, the rainy season onsets were later. The anomalous easterlies became stronger corresponds to the increasing zonal sea surface temperature anomaly (SSTA) gradient between the Indian Ocean and the Northwest Pacific Ocean. There was no significant anomaly on the rainy season onset during the cold PDO phase. During the La Niña events, the abnormal westerlies in BOB accelerated water vapour transport, and the rainy season onset were earlier during the warm and cold PDO phase. The modulating effects of PDO on La Niña were less than those on El Niño. These results suggest that the predictability of rainy season onset over the ICP can be improved through PDO and thus help agricultural planning and water resources management.
A comparative analysis of temperature trends at Modena Geophysical Observatory and Mount Cimone Observatory, Italy
Authors: Costanzini Sofia , Boccolari Mauro , Vega Parra Stephanie , Despini Francesca , Lombroso Luca , Teggi Sergio 
Published: August 2024

AbstractGlobal warming has become a critical environmental, social, and economic threat, with increasing frequency and intensity of extreme weather events. This study aims to analyse temperature trends and climate indices in the Po Valley, a significant economic and agricultural region in Italy, by examining data from two historical stations: the urban Modena Observatory and the rural Mount Cimone Observatory. The analysis extends previous studies to 2018, assessing the magnitude of climate changes since the 1950s and isolating the Urban Heat Island (UHI) effect in Modena. Significant warming trends were confirmed at both sites, with in maximum (TX) and minimum (TN) temperatures trends nearly doubling from 1981 to 2018 compared to 1951–2018. For example, TX trends reached 0.84°C·decade−1 in Modena and 0.62°C·decade−1 at Mount Cimone, while TN trends were 0.77 and 0.80°C·decade−1, respectively. Extreme climate indices showed a substantial increase in warm days and nights (TX90p and TN90p, respectively). Particularly we found TX90p of 27.5 days·decade−1 in Modena and 15 days·decade−1 at Mount Cimone while TN90p of 29.5 days·decade−1 in Modena, 22 days·decade−1 at Mount Cimone. The UHI effect significantly impacts Modena's temperature trends. Urbanization contributes up to 65% of the rise in warm nights. Specifically, frost days decreased by 1.88 days·decade−1 (37% of Urban Contribute, UC), tropical nights increased by 5.16 days·decade−1 (57% UC), warm nights increased by 12.7 days·decade−1 (65% UC), and cool nights decreased by 3.19 days·decade−1 (39% UC). Overall, the study underscores the importance of considering both global and local factors in regional climate trend analysis.
Refractory pyoderma gangrenosum in Caucasian adolescent with Takayasu arteritis and life‐threatening infections
Authors: Yeo Ting Fong , Labbouz Sofia , Lawrance Nicholas , Sitaraaman Hemalatha Bhuvanai , Tattersall Rachel S. , Cork Michael J. 
Published: August 2024

AbstractPyoderma gangrenosum (PG) in Caucasians with Takayasu's arteritis (TA) is uncommon. We described a case of refractory PG in an 18‐year‐old Caucasian man with TA since the age of 10 and was treated with corticosteroids, methotrexate, anti‐TNF therapy (adalimumab), anti‐CD20 therapy (rituximab), cyclophosphamide and most latterly tocilizumab and leflunomide. He has vascular stenosis complicated with renovascular hypertension and is steroid‐dependent. He presented with a 6‐week history of a left cheek rapidly enlarging lesion associated with pain, bleeding and purulent discharge not responding to flucloxacillin. Incisional biopsy suggested PG. He later developed similar lesions on the volar aspect of the right hand and at venepuncture sites. Despite topical immunosuppressive medication and high‐dose pulsed intravenous methylprednisolone, the left cheek lesion continued to grow rapidly. These painful, unsightly ulcers caused significant psychosocial stress and limited his daily life. Following a multidisciplinary team (MDT) discussion, tocilizumab was switched to abrocitinib. While initial improvement of lesions was observed, he subsequently developed an acneiform eruption which evolved into PG and became superinfected with herpes zoster virus and Staphylococcus aureus, requiring hospitalisation for intravenous (IV) acyclovir and antibiotics. Following several MDT discussions, abrocitinib was discontinued and a new regimen consisting of ciclosporin, dapsone and enhanced frequency IV immunoglobulin (IVIg) every 2 weeks was initiated, effectively stabilising his PG. This case highlights the rare association of PG and TA in Caucasians, the complexities of managing PG complicated by severe infections and underlying immunodeficiency, and the significant psychosocial burden of PG.
Microplastics may reduce the efficiency of the biological carbon pump by decreasing the settling velocity and carbon content of marine snow
Authors: Roberts Cordelia , Flintrop Clara M. , Khachikyan Alexander , Milucka Jana , Munn Colin B. , Iversen Morten H. 
Published: August 2024

AbstractPlastics are pervasive in marine ecosystems and ubiquitous in both shallow and deep oceans. Microfibers, among other microplastics, accumulate in deep‐sea sediments at concentrations up to four orders of magnitude higher than in surface waters. This is at odds with the fact that most microfibers are positively buoyant; therefore, it is hypothesized that settling aggregates are vectors for the downward transport of microfibers in the ocean. However, little is known about the impact of microfibers on carbon export. We formed diatom aggregates with differing concentrations of microfibers using roller tanks and observed that microfiber addition stimulated aggregate formation, but decreased their structural cohesion and caused them to break apart more readily, resulting in smaller average sizes. The incorporation of positively buoyant microfibers into settling aggregates reduced their size‐specific sinking velocities proportional to the microfiber concentration. Slower sinking may extend aggregate retention time in the upper ocean, thereby increasing the time available for organic matter remineralization in the upper water column. Here, we show that at concentrations of 105 microfibers per cubic meter, microfiber incorporation into settling marine aggregates decreases potential export flux by 8–45%. Microfibers accumulating at such high concentrations, for example, in Arctic sea ice, may, therefore, be substantially reducing the efficiency of the biological carbon pump relative to the pre‐plastic era.
Calcification increases carbon supply, photosynthesis, and growth in a globally distributed coccolithophore
Authors: Grubb Austin R. , Johns Christopher T. , Hayden Matthew G. , Subhas Adam V. , Thamatrakoln Kimberlee , Bidle Kay D. 
Published: August 2024

AbstractCoccolithophores fix organic carbon and produce calcite plates (coccoliths) that ballast organic matter and facilitate carbon export. Photosynthesis consumes carbon dioxide, while calcification produces it, raising questions about whether coccolithophores are a net sink or source of carbon. We characterized the physiology of calcified and noncalcified (“naked”) phenotypes of Emiliania huxleyi (CCMP374) and investigated the relationship between calcification and photosynthesis across a gradient of light (25–2000 μmol photons m−2 s−1) spanning the euphotic zone. Growth and photophysiological parameters increased with light until reaching a mid‐light (150 μmol photons m−2 s−1) maximum for both phenotypes. Calcified cells were characterized by enhanced photophysiology and less photoinhibition. Further, enhanced bicarbonate transport in calcified cells led to higher rates of particulate organic carbon fixation and growth compared to naked cells at mid‐light to high light (150–2000 μmol photons m−2 s−1). Coccolith production was similarly high at mid and high light, but the rate of coccolith shedding was >3‐fold lower at high‐light (1.2 vs. 0.35 coccoliths cell−1 h−1). The cellular mechanims(s) of this differential shedding remain unknown and underly light‐related controls on coccosphere maintenance. Our data suggest coccoliths shade cells at high light and that enhanced bicarbonate transport associated with calcification increases internal carbon supplies available for organic carbon fixation.