bluuebunny/crossref_metadata_2025_split huggingface dataset:
Burden and predictors of hypertension in India: results of SEEK (Screening and Early Evaluation of Kidney Disease) study
Authors: Farag Youssef MK , Mittal Bharati V , Keithi-Reddy Sai Ram , Acharya Vidya N , Almeida Alan F , C Anil , HS Ballal , P Gaccione , R Issacs , Jasuja Sanjiv , AL Kirpalani , V Kher , GK Modi , Nainan Georgy , Prakash Jai , Rajapurkar Mohan M , DS Rana , Sreedhara Rajanna , DK Sinha , Shah Bharat V , Sunder Sham , Sharma Raj Kumar , Seetharam Sridevi , Raju Tatapudi Ravi , Singh Ajay K 
Published: March 2014

AbstractBackgroundHypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India.Methods6120 subjects participated in the Screening and Early Evaluation of Kidney disease (SEEK), a community-based screening program in 53 camps in 13 representative geographic locations in India. Of these, 5929 had recorded blood pressure (BP) measurements. Potential predictors of HTN were collected using a structured questionnaire for SEEK study.ResultsHTN was observed in 43.5% of our cohort. After adjusting for center variation (p < 0.0001), predictors of a higher prevalence of HTN were older age ≥40 years (p < 0.0001), BMI of ≥ 23 Kg/M2(p < 0.0004), larger waist circumference (p < 0.0001), working in sedentary occupation (p < 0.0001), having diabetes mellitus (p < 0.0001), having proteinuria (p < 0.0016), and increased serum creatinine (p < 0.0001). High school/some college education (p = 0.0016), versus less than 9th grade education, was related with lower prevalence of HTN. Of note, proteinuria and CKD were observed in 19% and 23.5% of HTN subjects. About half (54%) of the hypertensive subjects were aware of their hypertension status.ConclusionsHTN was common in this cohort from India. Older age, BMI ≥ 23 Kg/M2, waist circumference, sedentary occupation, education less, diabetes mellitus, presence of proteinuria, and raised serum creatinine were significant predictors of hypertension. Our data suggest that HTN is a major public health problem in India with low awareness, and requires aggressive community-based screening and education to improve health.
TLR ligands up-regulate Trex1 expression in murine conventional dendritic cells through type I Interferon and NF-κB-dependent signaling pathways
Authors: Xu Jun , Zoltick Philip W , Gamero Ana M , Gallucci Stefania 
Published: March 2014

ABSTRACTMutations in the Trex1 are associated with a spectrum of type I IFN-dependent autoimmune diseases. Trex1 plays an essential role in preventing accumulation of excessive cytoplasmic DNA, avoiding cell-intrinsic innate DNA sensor activation and suppressing activation of type I IFN-stimulated and -independent antiviral genes. Trex1 also helps HIV to escape cytoplasmic detection by DNA sensors. However, regulation of Trex1 in innate immune cells remains elusive. We report that murine cDCs have high constitutive expression of Trex1 in vitro and in vivo in the spleen. In resting bone marrow-derived cDCs, type I IFNs up-regulate Trex1 expression via the IFNAR-mediated signaling pathway (STAT1- and STAT2-dependent). DC activation induced by TLR3, -4, -7, and -9 ligands also augments Trex1 expression through autocrine IFN-β production and triggering of the IFN signaling pathway, whereas TLR4 ligand LPS also stimulates an early expression of Trex1 through IFN-independent NF-κB-dependent signaling pathway. Furthermore, retroviral infection also induces Trex1 up-regulation in cDCs, as we found that a gene therapy HIV-1-based lentiviral vector induces significant Trex1 expression, suggesting that Trex1 may affect local and systemic administration of gene-therapy vehicles. Our data indicate that Trex1 is induced in cDCs during activation upon IFN and TLR stimulation through the canonical IFN signaling pathway and suggest that Trex1 may play a role in DC activation during infection and autoimmunity. Finally, these results suggest that HIV-like viruses may up-regulate Trex1 to increase their ability to escape immunosurveillance.
GAD Autoantibody Affinity in Adult Patients With Latent Autoimmune Diabetes, the Study Participants of a GAD65 Vaccination Trial
Authors: Krause Stephanie , Landherr Ulrike , Agardh Carl-David , Hausmann Simone , Link Katarina , Hansen Jesse M. , Lynch Kristian F. , Powell Michael , Furmaniak Jadwiga , Rees-Smith Bernard , Bonifacio Ezio , Ziegler Anette G. , Lernmark Åke , Achenbach Peter 
Published: March 2014

OBJECTIVE
Patients with latent autoimmune diabetes in adults (LADA) express autoantibodies against the 65-kDa isoform of GAD (GADA). Intervention with recombinant human GAD65 formulated with aluminium hydroxide (GAD-alum) given twice subcutaneously to LADA patients at intervals of 4 weeks was safe and did not compromise β-cell function in a Phase II clinical trial. GADA affinity has been shown to predict progression to type 1 diabetes. Here, we asked whether GADA affinity was affected by the GAD65 antigen-specific vaccination and/or associated with β-cell function in participants of this trial.

RESEARCH DESIGN AND METHODS
GADA affinity was measured in sera of 46 LADA patients obtained prior to the first week and 20 weeks after the second injection with GAD-alum or placebo using competitive binding experiments with [125I]-labeled and unlabeled human GAD65.

RESULTS
At baseline, GADA affinities ranged from 1.9 × 107 to 5.0 × 1012 L/mol (median 2.8 × 1010 L/mol) and were correlated with GADA titers (r = 0.47; P = 0.0009), fasting (r = −0.37; P = 0.01) and stimulated (r = −0.40; P = 0.006) C-peptide concentrations, and HbA1c (r = 0.39; P = 0.007). No significant changes in affinity were observed from baseline to week 24. Patients with GADA affinities in the lower first quartile (&lt;4 × 109 L/mol) had better preserved fasting C-peptide concentrations at baseline than those with higher affinities (mean 1.02 vs. 0.66 nmol/L; P = 0.004) and retained higher concentrations over 30 months of follow-up (mean 1.26 vs. 0.62 nmol/L; P = 0.01).

CONCLUSIONS
Intervention with GAD-alum in LADA patients had no effect on GADA affinity. Our data suggest that patients with low GADA affinity have a prolonged preservation of residual β-cell function.
Reasons for (not) Signing the State Registry: Surveying Department of Motor Vehicles Customers in New York State
Authors: Feeley Thomas Hugh , Reynolds-Tylus Tobias , Anker Ashley E. , Evans Melanie 
Published: March 2014

Context Prior research examining rationales for enrolling as an organ donor is biased because of its reliance on college student samples and retrospective recall. Objective To characterize New York state residents' registry enrollment decisions in close proximity to a registration opportunity. Design Surveys were conducted with customers exiting Department of Motor Vehicle offices. Participants A total of 1325 customers were surveyed upon exiting 1 of 18 Department of Motor Vehicle offices spanning 9 counties. Main Outcome Measure Customers making donation-relevant transactions (ie, license renewal/registration) reported whether they had registered as a donor that day, and all other customers reported whether they had registered as a donor in the past. Customers reported reasons to justify their enrollment decision through short interview questions. Results Among current donation-relevant transactions (n = 299), 27% reported enrolling in the registry. Of remaining customers, 39% reported enrolling in the state registry in the past. For those who elected not to enroll, many failed to communicate a reason for their decision, or reported a lack of opportunity to sign or decisional uncertainty. Among enrollees, reasons for registration included the altruistic benefits of donation, prior registration, personal experience with donation, and rational arguments for donation. Conclusion The value of point-of-decision survey data are discussed in relation to strategic efforts to promote organ donor registration.
Protecting and Enhancing Eyewitness Memory: The Impact of an Initial Recall Attempt on Performance in an Investigative Interview
Authors: Hope Lorraine , Gabbert Fiona , Fisher Ronald P. , Jamieson Kat 
Published: March 2014

SummaryEvidence‐gathering begins at the scene of an incident. Available witnesses may be asked to provide an account of what happened, either in response to an open request for information or, in some regions, by completing a Self‐Administered Interview (SAI©). In both cases, an investigative interview may be conducted at some later date. This study sought to determine the impact of an initial retrieval attempt on a subsequent interview. After exposure to a mock crime, participants completed an SAI© or a free recall (FR), or did not engage in an initial retrieval (Control). One week later, participants were interviewed with a Cognitive Interview. SAI© participants reported more correct information and maintained higher accuracy than FR and Control participants. Consistency analyses revealed that the SAI© was effective because it preserved more of the originally recalled items (Time 1) than did an initial FR, and not because it yielded new recollections at Time 2. Copyright © 2014 John Wiley & Sons, Ltd.
Kompensatorische Anpassungen der strukturellen Dynamik eines intrinsisch unstrukturierten Protein‐Komplexes
Authors: Kurzbach Dennis , Schwarz Thomas C. , Platzer Gerald , Höfler Simone , Hinderberger Dariush , Konrat Robert 
Published: March 2014

AbstractIntrinsisch unstrukturierte Proteine (IUPs) spielen eine zentrale Rolle in Proteininteraktionsnetzwerken als wichtige Knotenpunkte und Kopplungsstellen. Hier zeigen wir mit einer Kombination aus NMR‐ und ESR‐Spektroskopie, dass die Bindung des Cytokins Osteopontin an seinen natürlichen Liganden Heparin von thermodynamisch kompensierend wirkenden Strukturanpassungen begleitet wird: Das Kernsegment des OPN entfaltet sich, und dieses “Entfalten durch Bindung” kompensiert entropische Verluste durch die Heparinbindung. Es wird gezeigt, dass dieser Prozess primär durch elektrostatische Wechselwirkungen zwischen Heparin und geladenen Regionen entlang des Proteinrückgrats bestimmt wird. Dieses Wechselspiel zwischen Struktur und Thermodynamik ist auch von grundlegender Bedeutung für IUPs zur schnellen Substratbindung und ‐freisetzung innerhalb von Wechselwirkungsnetzwerken.
Lemierre's syndrome after evacuation of the uterus: a case report
Authors: Hedengran Katrine Kaare , Hertz Jens 
Published: March 2014

Key Clinical MessageEven minor surgical interventions can have serious complications. Lemierre's syndrome is rare and to our best knowledge never before described after gynecological surgery; however, it should be considered in case of rapidly developing respiratory problems after even simple surgical procedures.
Dendrimer‐Encapsulated Cobalt Nanoparticles as High‐Performance Catalysts for the Hydrolysis of Ammonia Borane
Authors: Aranishi Kengo , Zhu Qi‐Long , Xu Qiang 
Published: March 2014

AbstractDendrimer‐encapsulated Co nanoparticles (G6‐OH(Co60)) have been synthesized through the complexation of Co2+ cations to the internal tertiary amine of sixth‐generation hydroxyl‐terminated poly(amidoamine) dendrimers followed by reduction by both sodium borohydride and ammonia borane in aqueous solution. The highly dispersed G6‐OH(Co60), in which the average diameter of Co nanoparticles is approximately 1.6±0.4 nm, have been confirmed by TEM analysis. The catalytic activity of G6‐OH(Co60) for the hydrolysis of ammonia borane has been studied in aqueous solution at different reaction temperatures, demonstrating a high catalytic performance.
ChemInform Abstract: Magnetic Structure and Properties of the Rechargeable Battery Insertion Compound Na2FePO4F.
Authors: Avdeev Maxim , Ling Chris D. , Tan Thiam Teck , Li Sean , Oyama Gosuke , Yamada Atsuo , Barpanda Prabeer 
Published: March 2014

AbstractNa2FePO4F is prepared by solid state reaction of an equimolar mixture of NaF, NaHCO3, FeC2O4, and NH4H2PO4 (argon, 300 °C, 2 h) followed by annealing of the pelletized product (argon, 600 °C, 8 h).
ChemInform Abstract: Structural and Magnetic Study of Order—Disorder Behavior in the Double Perovskites Ba2Nd1‐xMnxMoO6.
Authors: Coomer Fiona C. , Cussen Edmund J. 
Published: March 2014

AbstractBa2Nd1‐xMnxMoO6 (0 < x ≤ 1) is prepared by calcination of stoichiometric mixtures of BaCO3, Nd2O3, MnO2, and MoO3 (air, 500—800 °C, 8 h) followed by solid state thermal reduction (5%H2/N2, 1250 °C, 2 d).
ChemInform Abstract: An Adaptable and Dynamically Porous Organic Salt Traps Unique Tetrahalide Dianions.
Authors: Marti‐Rujas Javier , Meazza Lorenzo , Lim Gin Keat , Terraneo Giancarlo , Pilati Tullio , Harris Kenneth D. M. , Metrangolo Pierangelo , Resnati Giuseppe 
Published: March 2014

AbstractThermal treatment of microcrystalline trihalides (II) affords the [I4]2‐ tetraiodide anion and its unique [I2Br2]2‐ and [I2Cl2]2‐ mixed analogs as uniform and microcrystalline salts (III) in nearly quantitative yield.
ChemInform Abstract: The Borosulfate Story Goes on — From Alkali and Oxonium Salts to Polyacids.
Authors: Daub Michael , Kazmierczak Karolina , Hoeppe Henning A. , Hillebrecht Harald 
Published: March 2014

AbstractThe crystal structures of (III), (V), and (VII)—(IX) are determined by single crystal XRD.
ChemInform Abstract: A Novel 3D Metal—Organic Framework with Silver Iodide Anion Cluster [Ag14I16]2‐ as Node: Synthesis, Structure, and Fluorescence Property.
Authors: Xu Wei‐Xia , Zhou Wei‐Xia , Li Jun , Huang Shi‐Liang , Niu Jiao , Zhang Feng‐Xing 
Published: March 2014

AbstractColorless block crystals of [Ag14I16(HDABCO)2]·DABCO are synthesized from AgI dissolved in saturated KI solution and DABCO in EtOH (room temperature, 14 d, 51% yield).
ChemInform Abstract: Lewis Acid—Surfactant‐Combined Catalyzed Synthesis of 4‐Aminocyclopentenones from Glycals in Water.
Authors: Wang Siming , William Ronny , Seah Kim Kui Georgina Estelle , Liu Xue‐Wei 
Published: March 2014

AbstractA facile methodology for the stereoselective construction of biologically significant 4‐aminocyclopentenones from readily available glycals and secondary arylamines is developed.
ChemInform Abstract: Scalable and Divergent Total Synthesis of (+)‐Colletoic Acid, a Selective 11β‐Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
Authors: Ling Taotao , Griffith Elizabeth , Mitachi Katsuhiko , Rivas Fatima 
Published: March 2014

AbstractAn efficient and divergent total synthesis of (+)‐colletoic acid (I), a selective 11‐β hydroxysteroid dehydrogenase 1 inhibitor, is presented along with its biological activity at the whole‐cell level.
ChemInform Abstract: Practical Metal‐Free Synthesis of Chalcone Derivatives via a Tandem Cross‐Dehydrogenative‐Coupling/Elimination Reaction.
Authors: Wei Yu , Tang Jinghua , Cong Xuefeng , Zeng Xiaoming 
Published: March 2014

AbstractA variety of (E)‐chalcones is readily prepared by reaction of ketones with benzylamines in the presence of ammonium persulfate.
ChemInform Abstract: Advances in Drug Design and Discovery. Part 25. Hybrid Benzofuran—Bisindole Derivatives: New Prototypes with Promising Antihyperlipidemic Activities.
Authors: Sashidhara Koneni V. , Modukuri Ram K. , Sonkar Ravi , Rao K. Bhaskara , Bhatia Gitika 
Published: March 2014

Abstract19 Title compounds of type (III) are prepared and evaluated in vitro for their antioxidant and in vivo for antidyslipidemic activities.
ChemInform Abstract: Tandem Michael Addition/Isocyanide Insertion into the C—C Bond: A Novel Access to 2‐Acylpyrroles and Medium‐Ring Fused Pyrroles.
Authors: Zhang Lingjuan , Xu Xianxiu , Shao Qiu‐rong , Pan Ling , Liu Qun 
Published: March 2014

AbstractThe base‐promoted reaction of cyclic enediones with isocyanides (II) leads to 7‐ and 8‐membered‐ring fused pyrroles (III) in moderate yields.
ChemInform Abstract: Expanding the Scope of the Indium‐Promoted Allylation Reaction: 4‐(Bromomethyl)‐1,3‐dioxol‐2‐one as a Synthetic Equivalent of a 3‐Arylhydroxyacetone Enolate.
Authors: Bigovic Miljan , Skaro Sanja , Maslak Veselin , Saicic Radomir N. 
Published: March 2014

AbstractCyclic enol carbonates (I), obtained via the indium‐promoted allylation of aldehydes with 4‐(bromomethyl)‐1,3‐dioxol‐2‐one, undergo a Heck reaction with aryl iodides in the presence of silver trifluoroacetate to give the corresponding arylated products.
ChemInform Abstract: Unexpected Regioselectivities of [3 + 2] Cycloaddition of Azomethine Imines to Acrylonitrile and 4‐Nitrophenyl Vinyl Sulfone.
Authors: Pleshchev Mikhail I. , Kachala Vadim V. , Goloveshkin Alexander S. , Bushmarinov Ivan S. , Kuznetsov Vladimir V. , Khakimov Dmitriy V. , Makhova Nina N. 
Published: March 2014

AbstractThe [3 + 2] cycloaddition of azomethinimines generated in situ from (I) to acrylonitrile (II) or 4‐nitrophenyl sulfone (V) proceeds with high diastereoselectivity but with opposite regioselectivity.
ChemInform Abstract: 3‐(3‐Butylamino‐2‐hydroxy‐propoxy)‐1‐hydroxy‐xanthen‐9‐one Acts as a Topoisomerase IIα Catalytic Inhibitor with Low DNA Damage.
Authors: Park So‐Eun , Chang In‐Hye , Jun Kyu‐Yeon , Lee Eunyoung , Lee Eung‐Seok , Na Younghwa , Kwon Youngjoo 
Published: March 2014

AbstractSeveral new aminoalkylxanthone derivatives (III) (8 examples) are synthesized by alkylamine mediated epoxide ring opening reaction of compounds (I), and evaluated for their pharmacological activities.
ChemInform Abstract: Asymmetric Synthesis of Chiral Dihydrothiopyrans via an Organocatalytic Enantioselective Formal Thio [3 + 3] Cycloaddition Reaction with Binucleophilic Bisketone Thioethers.
Authors: Zhang Wannian , et al. et al. 
Published: March 2014

AbstractAn unprecedented organocatalytic formal [3 + 3] cycloaddition process is described to yield 3,4‐dihydro‐2H‐thiopyrane derivatives from thiodiketones and cinnamic aldehydes.
ChemInform Abstract: Synthesis, in vitro Evaluation and Molecular Modelling of Naphthalimide Analogues as Anticancer Agents.
Authors: Verma Meenakshi , Luxami Vijay , Paul Kamaldeep 
Published: March 2014

Abstract11 Title compounds of type (V) are prepared and are evaluated for in vitro antitumor activities against 60 tumor cell lines.
ChemInform Abstract: Facile One‐Pot Synthesis of the Pyrazolo[1,5‐a]pyrazine Scaffold.
Authors: Zaremba O. V. , Gorobets N. Yu. , Kovalenko S. S. , Drushlyak O. G. , Grevtsov O. Yu. , Kovalenko S. M. 
Published: March 2014

AbstractTitle compounds (III) are synthesized by three‐component condensation through amide formation, pyrazine ring closure, and hydrolysis/dehydration.
ChemInform Abstract: Mannich Reaction in the Synthesis of N,S‐Containing Heterocycles. Part 16. Synthesis of Derivatives of Tetrahydropyrido[1,2‐a][1,3,5]triazine and 5,6,12,13‐Tetrahydro‐1H,8H‐dipyrido[1,2‐a:1′,2′‐e][1,3,5,7]tetrazocine.
Authors: Dotsenko V. V. , Suikov S. Yu. , Pekhtereva T. M. , Krivokolysko S. G. 
Published: March 2014

AbstractThe base‐mediated aminomethylation of 6‐amino‐4‐aryl‐2‐thioxo‐1,2‐dihydropyridine‐3,5‐dicarbonitriles (I) provides access to pyridotriazine and tetrazocine derivatives in ratios depending strongly on the structure of the initial amine, the ratio of regents, and the reaction conditions.
ChemInform Abstract: Synthesis and Antimicrobial Activity of 3‐Aryl‐2,6‐diphenylimino‐4‐S‐hepta‐O‐benzoyl‐lactosyl‐2,3‐dihydro‐1,3,5‐ thiadiazine Hydrochlorides.
Authors: Deshmukh Reena J. , Deshmukh Shirish P. 
Published: March 2014

AbstractAll new compounds (III) (7 examples) show antibacterial and antifungal activities similar to the standards amikacin and fluconazole.
ChemInform Abstract: Efficient Asymmetric Synthesis of Lamivudine via Enzymatic Dynamic Kinetic Resolution.
Authors: Hu Lei , Schaufelberger Fredrik , Zhang Yan , Ramstroem Olof 
Published: March 2014

AbstractThe protease subtilisin Carlsberg treated with octyl β‐D‐glucopyranoside and Brij 56 surfactants is used for the novel enzymatic DKR reaction of dithianediol (I) with aldehyde (II) and phenyl acetate.
ChemInform Abstract: Biomass Feedstocks for Renewable Fuel Production: A Review of the Impacts of Feedstock and Pretreatment on the Yield and Product Distribution of Fast Pyrolysis Bio‐Oils and Vapors
Authors: Carpenter Daniel , Westover Tyler L. , Czernik Stefan , Jablonski Whitney 
Published: March 2014

AbstractReview: 161 refs.
Band‐Structure Engineering of ZnO by Anion–Cation Co‐Doping for Enhanced Photo‐Electrochemical Activity
Authors: Pan Jing , Wang Shudong , Chen Qian , Hu Jingguo , Wang Jinlan 
Published: March 2014

AbstractTo look for efficient visible light‐driven catalysts for photo‐electrochemical (PEC) water‐splitting, the band structure and optical absorption of monodoped, compensated, and noncompensated n–p pairs of co‐doped bulk ZnO are systemically studied by using both general gradient approximation and hybrid density functional theory approaches (PBE and HSE). Calculations show that n–p co‐doping cannot only enhance the stability that stems from the strong electrostatic attraction between the n‐ and p‐type dopants, but also effectively reduce the band‐gap of ZnO. More importantly, compensated (Ti+C) and noncompensated (Sc+C) and (Cr+C) co‐doped ZnO may be compelling candidates for PEC water‐splitting because of their narrowed band‐gaps, potentially reduced electron–hole recombination centers, appropriate band‐edge positions, enhanced optical absorption, and good stability.
Investment Valuation with Tax-optimized Financing Decisions and a Tax-optimized Default Alternative
Authors: Hundsdoerfer Jochen , Kruschwitz Lutz , Lorenz Daniela 
Published: March 2014

AbstractIn this paper we evaluate an indivisible investment project that is carried out in a corporation under very simple premises. In particular, we discuss a one-period model with certainty, the pure domestic case and proportional tax rates. Surprisingly, the decision problem turns out to be rather complex if one has to make allowance for different taxation of the corporation and its owner. Altogether there are more than 10 cases that have to be distinguished if the firm’s managers want to make a correct decision, depending on the relation of personal and corporate tax rates.
Using Dynamic Programming Decomposition for Revenue Management with Opaque Products
Authors: Gönsch Jochen , Steinhardt Claudius 
Published: March 2014

AbstractOpaque products enable service providers to hide specific characteristics of their service fulfillment from the customer until after purchase. Prominent examples include internet-based service providers selling airline tickets without defining details, such as departure time or operating airline, until the booking has been made. Owing to the resulting flexibility in resource utilization, the traditional revenue management process needs to be modified. In this paper, we extend dynamic programming decomposition techniques widely used for traditional revenue management to develop an intuitive capacity control approach that allows for the incorporation of opaque products. In a simulation study, we show that the developed approach significantly outperforms other well-known capacity control approaches adapted to the opaque product setting. Based on the approach, we also provide computational examples of how the share of opaque products as well as the degree of opacity can influence the results.
The Car Resequencing Problem with Pull-Off Tables
Authors: Boysen Nils , Golle Uli , Rothlauf Franz 
Published: March 2014

AbstractThe car sequencing problem determines sequences of different car models launched down a mixed- model assembly line. To avoid work overloads of workforce, car sequencing restricts the maximum occurrence of labor-intensive options, e.g., a sunroof, by applying sequencing rules. We consider this problem in a resequencing context, where a given number of buffers (denoted as pull-off tables) is available for rearranging a stirred sequence. The problem is formalized and suited solution procedures are developed. A lower bound and a dominance rule are introduced which both reduce the running time of our graph approach. Finally, a real-world resequencing setting is investigated.