bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of poly(n‐isopropylacrylamide)–CNT–polyaniline three‐dimensional electrospun microfabric scaffolds on cell growth and viability
Authors: Tiwari Ashutosh , Sharma Yashpal , Hattori Shinya , Terada Dohiko , Sharma Ashok K. , Turner Anthony P. F. , Kobayashi Hisatoshi 
Published: October 2012

AbstractThis study investigates the effect on: (1) the bulk surface and (2) the three‐dimensional non‐woven microfabric scaffolds of poly(N‐isopropylacrylamide)–CNT–polyaniline on growth and viability of cells. The poly(N‐isopropylacrylamide)–CNT–polyaniline was prepared using coupling chemistry and electrospinning was then used for the fabrication of responsive, non‐woven microfabric scaffolds. The electrospun microfabrics were assembled in regular three‐dimensional scaffolds with OD: 400–500 μm; L: 6–20 cm. Mice fibroblast cells L929 were seeded on the both poly(N‐isopropylacrylamide)–CNT–polyaniline bulk surface as well as non‐woven microfabric scaffolds. Excellent cell proliferation and viability was observed on poly(N‐isopropylacrylamide)–CNT–polyaniline non‐woven microfabric matrices in compare to poly(N‐isopropylacrylamide)–CNT–polyaniline bulk and commercially available Matrigel™ even with a range of cell lines up to 168 h. Temperature dependent cells detachment behavior was observed on the poly(N‐isopropylacrylamide)–CNT–polyaniline scaffolds by varying incubation at below lower critical solution temperature of poly(N‐isopropylacrylamide). The results suggest that poly(N‐isopropylacrylamide)–CNT–polyaniline non‐woven microfabrics could be used as a smart matrices for applications in tissue engineering. © 2012 Wiley Periodicals, Inc. Biopolymers 99: 334–341, 2013.
Electrical Behaviour of Heterobimetallic [MM′(EtCS2)4] (MM′=NiPd, NiPt, PdPt) and MM′X‐Chain Polymers [PtM(EtCS2)4I] (M=Ni, Pd)
Authors: Givaja Gonzalo , Castillo Oscar , Mateo Eva , Gallego Almudena , Gómez‐García Carlos J. , Calzolari Arrigo , di Felice Rosa , Zamora Félix 
Published: October 2012

AbstractHerein, we report the isolation of new heterobimetallic complexes [Ni0.6Pd1.4(EtCS2)4] (1), [NiPt(EtCS2)4] (2) and [Pd0.4Pt1.6(EtCS2)4] (3), which were constructed by using transmetallation procedures. Subsequent oxidation with iodine furnished the MM′X monodimensional chains [Ni0.6Pt1.4(EtCS2)4I] (4) and [Ni0.1Pd0.3Pt1.6(EtCS2)4I] (5). The physical properties of these systems were investigated and the chain structures 4 and 5 were found to be reminiscent of the parent [Pt2(EtCS2)4I] species. However, they were more sensitively dependent on the localised nature of the charge on the Ni ion, which caused spontaneous breaking of the conduction bands.
ChemInform Abstract: Bifunctional Mixed‐Lanthanide Cyano‐Bridged Coordination Polymers Ln0.5Ln′0.5(H2O)5 [W(CN)8] (Ln/Ln′ = Eu3+/Tb3+, Eu3+/Gd3+, Tb3+/Sm3+.
Authors: Larionova Joulia , et al. et al. 
Published: October 2012

AbstractSingle crystals of the title compounds are prepared by slow diffusion of diethyl ether into MeCN solutions of [NBu4]3[W(CN)8], Ln(NO3)3 (Ln: Eu, Tb), and Ln′(NO3)3 (Ln′: Tb, Gd, Sm).
ChemInform Abstract: Tuning of Water and Hydroxide Content of Intercalated Ruddlesden—Popper‐Type Oxides in the PrSr3Co1.5Fe1.5O10‐δ System.
Authors: Jantsky Laurent , Okamoto Hiroshi , Demont Antoine , Fjellvaag Helmer 
Published: October 2012

AbstractThe hydration behavior of the title phase (space group I4/mmm) is investigated to clarify phase formation and underlying mechanisms and driving forces.
ChemInform Abstract: [V16O38(CN)]9‐: A Soluble Mixed‐Valence Redox‐Active Building Block with Strong Antiferromagnetic Coupling.
Authors: Keene Tony D. , D'Alessandro Deanna M. , Kraemer Karl W. , Price Jason R. , Price David J. , Decurtins Silvio , Kepert Cameron J. 
Published: October 2012

AbstractSmall greenish black crystals of K9[V16O38(CN)]·13H2O are prepared by dissolving VO(SO4) in an aqueous solution of KCN followed by slow addition of MeOH (89% yield).
ChemInform Abstract: Synthesis, Crystal Structure, Transport, and Magnetic Properties of Novel Ternary Copper Phosphides, A2Cu6P5 (A: Sr, Eu) and EuCu4P3.
Authors: Charkin Dmitri O. , et al. et al. 
Published: October 2012

AbstractSr2Cu6P5 (I), Eu2Cu6P5 (II), and EuCu4P3 (III) are synthesized from the elements in evacuated silica ampules (200, 400, 600 °C, 12 h each, 800 °C, 48 h, and 900 °C, 20 h).
ChemInform Abstract: Organocatalytic Michael Reaction of Nitroenamine Derivatives with Aldehydes: Short and Efficient Asymmetric Synthesis of (‐)‐Oseltamivir.
Authors: Weng Jiang , Li Yong‐Bo , Wang Rui‐Bin , Lu Gui 
Published: October 2012

AbstractAsymmetric Michael addition of aldehydes towards nitroenamines is efficiently achieved in the presence of diphenylprolinol silyl ether as organocatalyst.
ChemInform Abstract: Practical Synthesis of 4,4,4‐Trifluorocrotonaldehyde: A Versatile Precursor for the Enantioselective Formation of Trifluoromethylated Stereogenic Centers via Organocatalytic 1,4‐Additions.
Authors: Shibatomi Kazutaka , Narayama Akira , Abe Yoshiyuki , Iwasa Seiji 
Published: October 2012

AbstractTitle compound (I) also reacts with triazoles and aldoximes.
ChemInform Abstract: A Facile Synthesis of 2H‐Chromenes and 9‐Functionalized Phenanthrenes Through Reactions Between α,β‐Unsaturated Compounds and Arynes.
Authors: Zhang Tiexin , Huang Xian , Wu Luling 
Published: October 2012

AbstractDepending on the nature of the electron‐withdrawing group at the α,β‐unsaturated compounds, the reactions proceed by two different pathways.
ChemInform Abstract: NaIO4—NaN3‐Mediated Diazidation of Styrenes, Alkenes, Benzylic Alcohols, and Aryl Ketones.
Authors: Kamble Dayanand A. , Karabal Pratibha U. , Chouthaiwale Pandurang V. , Sudalai Arumugam 
Published: October 2012

AbstractVarious substrates can be successfully transformed to diazides as precursors of synthetically important diamines.
ChemInform Abstract: Tandem Cross‐Dimerization/Oxonia‐Cope Reaction of Carbonyl Compounds to Homoallylic Esters and Lactones.
Authors: Zou Yue , Ding Changming , Zhou Lijun , Li Zhiming , Wang Quanrui , Schoenebeck Franziska , Goeke Andreas 
Published: October 2012

AbstractAn unprecedented stereoselective allylation is observed in the Lewis acid‐catalyzed reaction of simple aldehydes with β,γ‐unsaturated carbonyl compounds.
ChemInform Abstract: An Efficient Synthesis of Dithiocarbamates under Ultrasound Irradiation in Water.
Authors: Azizi Najmadin , Gholibeglo Elahm , Nayeri Sanaz Dehghan 
Published: October 2012

AbstractDithiocarbamates (IV), (VI), (VIII), (X) and (XII) are obtained by a simple one‐pot, three‐component condensation of either electron‐deficient olefins or alkyl halides with amines and carbon disulfide under ultrasonic irradiation.
ChemInform Abstract: New Approach to the Preparation of Bicyclo Octane Derivatives via the Enantioselective Cascade Reaction Catalyzed by Chiral Diamine‐Ni(OAc)2 Complex.
Authors: Li Wenyi , Liu Xiaodong , Mao Zhifeng , Chen Qiao , Wang Rui 
Published: October 2012

AbstractA simple and highly efficient reaction of various 1,2‐diones with substituted nitroalkenes is reported.
ChemInform Abstract: Gold‐Catalyzed C—H Oxidative Polyacyloxylation Reaction of Hindered Arenes.
Authors: Pradal Alexandre , Faudot dit Bel Pierre , Toullec Patrick Y. , Michelet Veronique 
Published: October 2012

AbstractThe synthesis of polyacetoxylated electron‐rich multi‐methylated arenes is achieved with diacetoxyiodobenzene (II).
ChemInform Abstract: Mild Ketone Formation via Ni‐Catalyzed Reductive Coupling of Unactivated Alkyl Halides with Acid Anhydrides.
Authors: Yin Hongyu , Zhao Chenglong , You Hengzhi , Lin Kunhua , Gong Hegui 
Published: October 2012

AbstractAn efficient procedure is elaborated for the coupling of alkyl iodides and bromides with anhydrides (I).
ChemInform Abstract: Microwave‐Assisted Reaction of Aryl Diazonium Fluoroborate and Diaryl Dichalcogenides in Dimethyl Carbonate: A General Procedure for the Synthesis of Unsymmetrical Diaryl Chalcogenides.
Authors: Kundu Debasish , Ahammed Sabir , Ranu Brindaban 
Published: October 2012

AbstractThe simplicity in operation, general applicability to all three chalcogenides (III), (V) and (VII), use of recycable dimethyl carbonate and employment of stable and readily available dichalcogenides in place of thiols and analogues makes the procedure environmentally friendly and more cost‐effective.
ChemInform Abstract: Switch of Selectivity in the Synthesis of α‐Methylene‐γ‐lactones: Palladium‐Catalyzed Intermolecular Carboesterification of Alkenes with Alkynes.
Authors: Huang Liangbin , Wang Qian , Liu Xiaohang , Jiang Huanfeng 
Published: October 2012

AbstractThe Pd‐catalyzed Cu‐mediated carboesterification of alkynoates with terminal olefins provides access towards E‐α‐methylene‐γ‐lactones, e.g. (III), (VII) and (XII), exclusively.
ChemInform Abstract: Catalytic Oxidation/C—H Functionalization of N‐Arylpropiolamides by Means of Gold Carbenoids: Concise Route to 3‐Acyloxindoles.
Authors: Qian Deyun , Zhang Junliang 
Published: October 2012

AbstractVarious 3‐acyloxindoles (II), (VI), and (XI) are readily obtained by gold‐catalyzed oxidative cyclization of corresponding N‐arylpropiolamides.
ChemInform Abstract: Iodine‐Catalyzed Synthesis of Thiopyrano[3,4‐c]quinoline Derivatives via Imino‐Diels—Alder Reaction.
Authors: Wang Wei , Yin Ming‐Yue , Zhang Mei‐Mei , Wang Xiang‐Shan 
Published: October 2012

AbstractThe title compounds (IV) and (VI) are efficiently obtained via a mild iodine‐catalyzed imino‐Diels—Alder reaction of various aromatic aldehydes (II), 5‐amino‐1H‐indazole (I) or 2‐aminoanthracene (V), and tetrahydrothiopyran‐4‐one (III).
ChemInform Abstract: Highly Efficient Synthesis of 3,4‐Dihydro‐2(1H)‐quinolinone Derivatives under Microwave Heating
Authors: Zhu Xiao‐Tong , Li Qiu‐yun , Jiang Bo , Tu Shu‐Jiang 
Published: October 2012

Abstractvia three‐component reaction of aromatic aldehydes with aromatic amine and Meldrum′s acid
ChemInform Abstract: Regioselective Synthesis of Pyrimido[1,2‐a][1,3,5]triazin‐6‐ones via Reaction of 1‐(6‐Oxo‐1,6‐dihydropyrimidin‐2‐yl)guanidines with Triethylorthoacetate: Observation of an Unexpected Rearrangement.
Authors: Sachdeva Nikhil , Dolzhenko Anton V. , Chui Wai Keung 
Published: October 2012

AbstractNovel thermal rearrangements are presented.
ChemInform Abstract: Synthesis and Biological Activity of Both Enantiomers of Kujigamberol Isolated from 85‐Million‐Years‐Old Kuji Amber.
Authors: Ye Yue Qi , Koshino Hiroyuki , Hashizume Daisuke , Minamikawa Yuki , Kimura Ken‐ichi , Takahashi Shunya 
Published: October 2012

AbstractBoth the natural enantiomer (I) and its (R)‐antipode show the same inhibitory activity toward mutant yeast and HL‐60 cells.
ChemInform Abstract: Thiophenol Analogues of Tocopherols and Tocotrienols.
Authors: Hyatt John A. , Dycus Megan , Nguyen Chau , Little James L. 
Published: October 2012

AbstractThe first synthetic access to tocotrienol thiophenol analogue (VIII) and a convenient route to tocopherol thiophenol analogues (VI) is described.
Influence of pretreatment conditions on composition of liquid hydrolysate and subsequent enzymatic saccharification of remaining solids
Authors: Dhabhai Ravi , Chaurasia Satyendra P. , Dalai Ajay K. 
Published: October 2012

AbstractIn the present work, the effect of dilute acid pretreatment was studied on the composition of liquid hydrolysate obtained after pretreatment by employing different combinations of process variables (temperature, time and acid concentration). The effect of pretreatment was also studied on subsequent enzymatic saccharification of remaining solids to obtain maximum yield of sugars. The efficiency of pretreatment was measured in terms of high‐xylose and low‐glucose yields, which was found most suitable at pretreatment conditions of 120°C, 120 min and 2% (v/v) acid concentration. With increased severity of pretreatment, xylose yield decreased with concomitant increase in glucose yield. The decrease in xylose yield was attributed to conversion into degradation products such as 5‐hydroxylmethyl furfural (HMF) and acetic acid. The percentage of enzymatic saccharification increased with increased pretreatment severity. Saccharification of biomass pretreated at 180°C, 7 min and 0.5% (v/v) acid concentration produced the maximum glucose yield of saccharification of 352 g/kg dry matter, compared to just 97 g glucose/kg dry matter in the case of untreated biomass. The same pretreatment conditions resulted in maximum total sugar yield of pretreatment and saccharification of 459 g/kg dry matter, which was more than 67% of the total potential sugars in biomass. © 2012 Canadian Society for Chemical Engineering
Numerical modelling of convective vapour condensation with non‐condensable gases between two coaxial vertical cylinders
Authors: Merouani Lazhar , Zeghmati Belkacem , Belhamri Azeddine 
Published: October 2012

AbstractA problem of laminar film condensation from steam–gas mixtures between two coaxial cylinders is numerically analysed. A set of complete boundary layer equations is used to model simultaneous momentum, heat and mass transfer in the liquid film and the vapour–gas mixture. In order to locate accurately the liquid–mixture interface, a relevant change of coordinates is performed. Equations are solved using an implicit finite difference scheme. The liquid film thickness is determined from an iterative procedure based on the secant method. An analytical solution of the momentum equations of both phases at the end of condensation is also developed. Results presented include evolutions of field profiles and flow parameters from the inlet until the end of condensation. We also analyse the effects of the wall properties, the inlet conditions, the type of non‐condensable gas, the size of the annular space and the convective cooling coefficient.
Effects of silver nanoparticles and silver nitrate in the earthworm reproduction test
Authors: Schlich Karsten , Klawonn Thorsten , Terytze Konstantin , Hund-Rinke Kerstin 
Published: October 2012

Abstract
The widespread use of silver nanoparticles (Ag-NPs), for example, in textiles and cleaning products, means that they are likely to reach the environment via biosolids or the effluent from wastewater treatment plants. The aim of the present study was to determine the ecotoxicity of Ag-NPs in the earthworm reproduction test using Eisenia andrei. In addition to the usual endpoints, the authors also investigated the uptake and accumulation of Ag by adult earthworms and the concentration of free Ag+ in soil pore water. Silver nanoparticles and Ag nitrate showed similar toxicities in the earthworm reproduction test. The uptake of Ag from Ag-NPs in the earthworm was slightly higher than the uptake of Ag from Ag nitrate. Spiked soils showed a concentration-dependent effect on reproduction, but there was no concentration-dependent increase in the amount of Ag in earthworm tissues. The authors noted a concentration-dependent increase in the levels of free Ag+ in the soil pore water regardless of the Ag source. The number of juveniles is a more suitable endpoint than biomass or mortality. The uptake of Ag does not appear to inhibit reproduction. Instead, inhibition seems to reflect Ag+ released into the soil pore water, which affects cocoons and juveniles in the soil. Analysis of transformed Ag-NPs after purification in wastewater treatment plants would provide additional information. Environ. Toxicol. Chem. 2013;32:181–188. © 2012 SETAC
A high‐resolution method for compressible two‐fluid flows and simulation of three‐dimensional shock–bubble interactions
Authors: Zheng J. G. , Lee T. S. 
Published: October 2012

SUMMARYA high‐resolution method is developed to capture the material interfaces of compressible two‐fluid flows in multiple dimensions. A fluid mixture model system with single velocity and pressure is used, and viscous effect can also be taken into account. A consistent thermodynamic law based on the assumption of pressure equilibrium is employed to describe the thermodynamic behaviors of the pure fluids and mixture of two components. The splitting and unsplit Eulerian formulations of piecewise parabolic method are extended to numerically integrate the hyperbolic part of the model system, whereas the system of diffusion equations is solved using an explicit, central difference scheme. The block‐structured adaptive mesh refinement (AMR) capability is built in the hydrodynamic code to locally improve grid resolution. The resulting method is verified to be at least second‐order accurate in space. Numerical results show that the discontinuities, particularly contact discontinuities, can be resolved sharply. The use of AMR allows flow features at disparate scales to be resolved sufficiently. In addition, three‐dimensional shock–bubble interactions are simulated to investigate effects of Mach number on bubble evolution. The flow structures including those peculiar to three‐dimensional bubble are resolved correctly, and some physical phenomena with increasing Mach number are reported. Copyright © 2012 John Wiley & Sons, Ltd.
Isolation and characterization of calcium sensing receptor null cells: A highly malignant and drug resistant phenotype of colon cancer
Authors: Singh Navneet , Liu Guangming , Chakrabarty Subhas 
Published: October 2012

AbstractThe expression of calcium sensing receptor (CaSR) in the human colonic crypt epithelium is linked to cellular differentiation while its lack of expression is associated with undifferentiated and invasive colon carcinoma. Human colon carcinoma cell lines contain small subpopulations (10–20%) that do not express CaSR (termed CaSR null cells). Here, we report on the isolation, propagation, maintenance and characterization of CaSR null cells from the CBS and HCT116 human colon carcinoma cell lines. CaSR null cells grew as three‐dimensional non‐adherent spherical clusters with increased propensity for anchorage independent growth, cellular proliferation and invasion of matrigels. CaSR null cells were highly resistant to fluorouracil and expressed abundant amount of thymidylate synthase and survivin. Molecular profiling by real time reverse transcription‐polymerase chain reaction (RT‐PCR) and Western blots showed a high level of expression of the previously reported cancer stem cell markers CD133, CD44 and Nanog in CaSR null cells. A significant increase in the expression of epithelial–mesenchymal transitional molecules and transcription factors was also observed. These include N‐cadherin, β‐catenin, vimentin, fibronectin, Snail1, Snail2, Twist and FOXC2. The expression of the tumor suppressive E‐cadherin and miR145, on the other hand, was greatly reduced while expression of the oncogenic microRNAs: miR21, miR135a and miR135b was significantly up‐regulated. CaSR null cells possess a myriad of cellular and molecular features that drive and sustain the malignant phenotype. We conclude that CaSR null constitutes a highly malignant and drug resistant phenotype of colon cancer.
Multifunctional nanobeacon for imaging Thomsen‐Friedenreich antigen‐associated colorectal cancer
Authors: Kumagai Hironori , Pham Wellington , Kataoka Makoto , Hiwatari Ken‐Ichiro , McBride James , Wilson Kevin J. , Tachikawa Hiroyuki , Kimura Ryoji , Nakamura Kunio , Liu Eric H. , Gore John C. , Sakuma Shinji 
Published: October 2012

AbstractThis research aimed to validate the specificity of the newly developed nanobeacon for imaging the Thomsen‐Friedenreich (TF) antigen, a potential biomarker of colorectal cancer. The imaging agent is comprised of a submicron‐sized polystyrene nanosphere encapsulated with a Coumarin 6 dye. The surface of the nanosphere was modified with peanut agglutinin (PNA) and poly(N‐vinylacetamide (PNVA) moieties. The former binds to Gal‐β(1‐3)GalNAc with high affinity while the latter enhances the specificity of PNA for the carbohydrates. The specificity of the nanobeacon was evaluated in human colorectal cancer cells and specimens, and the data were compared with immunohistochemical staining and flow cytometric analysis. Additionally, distribution of the nanobeacon in vivo was assessed using an “intestinal loop” mouse model. Quantitative analysis of the data indicated that approximately 2 μg of PNA were detected for each milligram of the nanobeacon. The nanobeacon specifically reported colorectal tumors by recognizing the tumor‐specific antigen through the surface‐immobilized PNA. Removal of TF from human colorectal cancer cells and tissues resulted in a loss of fluorescence signal, which suggests the specificity of the probe. Most importantly, the probe was not absorbed systematically in the large intestine upon topical application. As a result, no registered toxicity was associated with the probe. These data demonstrate the potential use of this novel nanobeacon for imaging the TF antigen as a biomarker for the early detection and prediction of the progression of colorectal cancer at the molecular level.
Knockdown of GPC3 inhibits the proliferation of Huh7 hepatocellular carcinoma cells through down‐regulation of YAP
Authors: Miao Hui‐Lai , Pan Zhi‐Jian , Lei Chang‐Jiang , Wen Ji‐Yu , Li Ming‐Yi , Liu Zhong‐Kao , Qiu Zhi‐Dong , Lin Man‐Zhou , Chen Nian‐Ping , Chen Ming 
Published: October 2012

AbstractGlypican‐3 (GPC3), a membrane‐associated heparan sulfate proteoglycan, is frequently upregulated in hepatocellular carcinoma (HCC). Yes‐associated protein (YAP) is also found over‐expressed in HCC and has been identified as a key effector molecule in Hippo pathway, which could control the organ size in animals through the regulation of cell proliferation and apoptosis and plays an important role in the development of malignant tumors. Studies have reported that GPC3 and YAP might collaborate to regulate the development of HCC. To elucidate the role of GPC3 in the development of HCC and its relationship with YAP, siRNA technique was employed to knock down GPC3 in Huh7 HCC cells. Moreover, recombinant human YAP‐1 was used to examine the effects of GPC3 on Huh7 cells. The results of flow cytometric analysis and Annexin‐V‐FLUOS apoptosis assay showed that knockdown of GPC3‐induced apoptosis in Huh7 cells, resulting in inhibition of cell proliferation as examined by EdU incorporation assay, migration, and invasion. GPC3 knockdown also suppressed the expression of YAP in mRNA and protein levels, as examined by fluorescence quantitative PCR and Western blot analysis. Moreover, addition of recombinant human YAP‐1 effectively rescued the cells from apoptosis triggered by GPC3 knockdown. Taken together, our findings suggest that GPC3 regulates HCC cell proliferation with the involvement of Hippo pathway. J. Cell. Biochem. 114: 625–631, 2013. © 2012 Wiley Periodicals, Inc.