bluuebunny/crossref_metadata_2025_split huggingface dataset:
The effects of simvastatin‐loaded nanoliposomes on human multilineage liver fibrosis microtissue
Authors: Parsa Shima , Dousti Maryam , Mohammadi Nasim , Abedanzadeh Mozhgan , Dehdari Ebrahimi Niloofar , Dara Mahintaj , Sani Mahsa , Nekouee Muhammad , Abolmaali Samira Sadat , Sani Farnaz , Azarpira Negar 
Published: July 2024

AbstractIn this in vitro study, for the first time, we evaluate the effects of simvastatin‐loaded liposome nanoparticles (SIM‐LipoNPs) treatment on fibrosis‐induced liver microtissues, as simvastatin (SIM) has shown potential benefits in the non‐alcoholic fatty liver disease process. We developed multicellular liver microtissues composed of hepatic stellate cells, hepatoblastoma cells and human umbilical vein endothelial cells. The microtissues were supplemented with a combination of palmitic acid and oleic acid to develop fibrosis models. Subsequently, various groups of microtissues were exposed to SIM and SIM‐LipoNPs at doses of 5 and 10 mg/mL. The effectiveness of the treatments was evaluated by analysing cell viability, production of reactive oxygen species (ROS) and nitric oxide (NO), the expression of Kruppel‐like factor (KLF) 2, and pro‐inflammatory cytokines (interleukin(IL)‐1 α, IL‐1 β, IL‐6 and tumour necrosis factor‐α), and the expression of collagen I. Our results indicated that SIM‐LipoNPs application showed promising results. SIM‐LipoNPs effectively amplified the SIM‐klf2‐NO pathway at a lower dosage compatible with a high dosage of free SIM, which also led to reduced oxidative stress by decreasing ROS levels. SIM‐LipoNPs administration also resulted in a significant reduction in pro‐inflammatory cytokines and Collagen I mRNA levels, as a marker of fibrosis. In conclusion, our study highlights the considerable therapeutic potential of using SIM‐LipoNPs to prevent liver fibrosis progress, underscoring the remarkable properties of SIM‐LipoNPs in activating the KLF2‐NO pathway and anti‐oxidative and anti‐inflammatory response.
Incorporating vertical movement of fishes in habitat use models
Authors: Richter Ian A. , Smokorowski Karen E. , Blanchfield Paul J. 
Published: July 2024

AbstractFish telemetry studies now routinely collect positional and depth data, yet analytical approaches that integrate three‐dimensional data are limited. Here we apply the potential path volume (PPV) model, a method previously developed to estimate habitat volume based on rates of avian movement, to free‐swimming fish. Using a telemetry dataset of white sucker (Catastomus commersonii) from Turkey Lake (Ontario, Canada), we evaluated the effects of the number of spatial positions and different methods of selecting swim speed (vswim), a key parameter for PPV models, on habitat volume estimates. We subsequently compared habitat volume estimates and habitat overlap among white sucker pairs from the PPV models to those calculated using kernel utilization distribution‐based approaches. The number of spatial positions in the PPV model had a significant effect on habitat volume estimates, whereas the magnitude of the vswim parameter or its specificity (constant value vs. fish‐season specific parameter values) did not affect habitat volume estimates. The PPV method resulted in larger habitat volume estimates and greater habitat overlap estimates among fish pairs relative to those obtained from a three‐dimensional kernel utilization distribution method. The PPV model is a useful analytical tool that, by incorporating potential animal movement into habitat use evaluations, can help answer key ecological questions and provide insight into fish space use in a wide range of conservation and management applications.
The taxonomy of tail risk
Authors: Stoja Evarist , Polanski Arnold , Nguyen Linh H. 
Published: July 2024

AbstractWe use tail events at different levels of severity to define an asset's tail risk and to decompose the latter into a systematic and an idiosyncratic component. The systematic component captures an asset's tendency to experience joint tail losses with the market and generalizes a classic tail dependence coefficient. However, the idiosyncratic component consists of two parts: idiosyncratic tail risk that leads to asset‐specific tail losses and tail risk cushioning that dampens the tail losses emanating from the market. Tail risk cushioning is a novel concept that arises naturally in our framework, is consistent with the previous two and completes the taxonomy of tail risk. We examine the performance of our tail risk decomposition on a large dataset, confirming some previous results on tail risk and uncovering new theoretical and empirical findings.
Machine learning for gap‐filling in greenhouse gas emissions databases
Authors: Cullen Luke , Marinoni Andrea , Cullen Jonathan 
Published: July 2024

AbstractGreenhouse gas (GHG) emissions datasets are often incomplete due to inconsistent reporting and poor transparency. Filling the gaps in these datasets allows for more accurate targeting of strategies aiming to accelerate the reduction of GHG emissions. This study evaluates the potential of machine learning methods to automate the completion of GHG datasets. We use three datasets of increasing complexity with 18 different gap‐filling methods and provide a guide to which methods are useful in which circumstances. If few dataset features are available, or the gap consists only of a missing time step in a record, then simple interpolation is often the most accurate method and complex models should be avoided. However, if more features are available and the gap involves non‐reporting emitters, then machine learning methods can be more accurate than simple extrapolation. Furthermore, the secondary output of feature importance from complex models allows for data collection prioritization to accelerate the improvement of datasets. Graph‐based methods are particularly scalable due to the ease of updating predictions given new data and incorporating multimodal data sources. This study can serve as a guide to the community upon which to base ever more integrated frameworks for automated detailed GHG emissions estimations, and implementation guidance is available at https://hackmd.io/@luke‐scot/ML‐for‐GHG‐database‐completion and https://doi.org/10.5281/zenodo.10463104. This article met the requirements for a gold‐gold JIE data openness badge described at http://jie.click/badges.
Cognitive and affective theory of mind in young and elderly patients with multiple sclerosis
Authors: Montembeault Maxime , Farley Romane , Ouellet Julie , Brando Estefania , Tremblay Alexandra , Charest Kim , Roger Élaine , Scherzer Peter , Duquette Pierre , Rouleau Isabelle 
Published: July 2024

AbstractTheory of mind (ToM) deficits have been reported in persons with multiple sclerosis (pwMS). However, most studies have used pictures or written scenarios as stimuli without distinguishing between cognitive and affective ToM, and no studies have investigated older pwMS. We recruited 13 young healthy controls (HC), 14 young pwMS, 14 elderly HC and 15 elderly pwMS. ToM was measured using an adaptation of the Conversations and Insinuations task (Ouellet et al., J. Int. Neuropsychol. Soc., 16, 2010, 287). In this ecological video‐based task, participants watch four 2‐minute videos of social interactions, which are interrupted by multiple choice questions about either the emotional state (affective ToM) or the intention (cognitive ToM) of the characters. They also underwent a short neuropsychological battery including cognitive, executive and social cognition tasks and questionnaires. We observed a significant interaction between the ToM conditions and the groups regarding ToM performance. Elderly pwMS scored significantly lower than elderly HC and young pwMS in cognitive ToM, but not in affective ToM. They also showed the largest discrepancy between their cognitive and affective ToM. Young pwMS showed relatively preserved ToM in both conditions. Both cognitive and affective ToM correlated with global cognition and executive abilities, but not with social cognitive measures (emotion recognition, real‐life empathy). This study suggests that decline in cognitive ToM might be accentuated by advancing age in pwMS. These impairments are most likely underlied by cognitive and executive difficulties, but not by core social cognitive impairments. Future studies should investigate the real‐life impacts of ToM impairments in pwMS.
Clinical, histologic, and immunologic signatures of Small Fiber Neuropathy in Systemic Lupus Erythematosus
Authors: Galosi Eleonora , Pirone Carmelo , Ceccarelli Fulvia , Esposito Nicoletta , Falco Pietro , Leopizzi Martina , Di Maio Valeria , Tramontana Lorenzo , De Stefano Gianfranco , Di Pietro Giuseppe , Di Stefano Giulia , Garufi Cristina , Leone Caterina , Natalucci Francesco , Orefice Valeria , Alessandri Cristiano , Spinelli Francesca Romana , Truini Andrea , Conti Fabrizio 
Published: July 2024

AbstractBackground and ObjectivesSystemic Lupus Erythematosus (SLE) often causes damage to small nerve fibers, leading to distressing painful and autonomic symptoms. Despite this, Small Fiber Neuropathy (SFN) remains an underrecognized complication for SLE patients. In this cross‐sectional study, we aimed to assess SFN in patients with SLE and to explore its correlations with immunologic disease features and clinical manifestations.MethodsWe recruited 50 SLE patients (1 male to 12.5 females, aged 20–80 years) reporting painful disturbances. We conducted a comprehensive clinical and neurophysiological evaluation, using Nerve Conduction Studies and Quantitative Sensory Testing. Additionally, we carried out an extensive laboratory assessment of disease‐related serological parameters. We also performed a thorough skin biopsy analysis, investigating somatic and autonomic innervation while detecting complement and inflammatory cell infiltrates within the skin.ResultsOut of 50 patients, 19 were diagnosed with SFN, primarily characterized by a non‐length‐dependent distribution; 7 had a mixed neuropathy, with both large and small fiber involvement. Patients with SFN were younger than patients with a mixed neuropathy (p = .0143); furthermore, they were more likely to have a history of hypocomplementemia (p = .0058) and to be treated with cyclosporine A (p = .0053) compared to patients without neuropathy. However, there were no significant differences in painful and autonomic symptoms between patients with and without SFN.DiscussionThis study highlights the relevant frequency of SFN with a non‐length‐dependent distribution among SLE patients experiencing painful symptoms. Indeed, SFN emerges as an early manifestation of SLE‐related neuropathy and is closely associated with hypocomplementemia, suggesting a potential pathogenic role of the complement system. Moreover, SFN may be influenced by disease‐modifying therapies. However, the precise role of SFN in shaping painful and autonomic symptoms in patients with SLE remains to be fully elucidated.
Laying train tracks en route: How institutional education leaders navigate complexity during mandated curriculum change
Authors: Tam Herman , Scott Ian 
Published: July 2024

AbstractIntroductionInstitutional education leaders serve key roles in leading major curricular change within residency education, yet little is known about how they accomplish these goals on the ground. Change management principles have predominantly been developed and described in the hierarchical context of management science and corporate settings. However, the non‐hierarchical, complex and adaptive features of health professions education may render these traditional change management models inadequate. We explored how institutional educational leaders navigate the complex residency education system in implementing a major curricular change.MethodsUsing constructivist grounded theory, we conducted and iteratively analysed semi‐structured interviews with 11 institutional education leaders from across Canada who were responsible for leading the nationally mandated curricular change to competency‐based residency education. Thematic analysis was performed iteratively using constant comparison.ResultsLeaders managing the change process focused on two priorities: steering the direction of the change process as it evolved and maintaining the momentum amongst stakeholders to move forward steadily. Four common threats and opportunities impacted the focus on direction and momentum: multiplicity of contexts, innovation, resistance and distractions. In response, leaders utilised various tactics and harnessed diverse leadership styles to manage these challenges accordingly.ConclusionsWe identified a change framework that offers a more contextually nuanced understanding of curricular change in residency education that has not been described in the change management literature generated by the management sector. Institutional education leaders focused on maintaining the direction and momentum, while constantly assessing and adapting to evolving, uncertain and complex conditions. Our findings provide a simple and practical foundation to support leadership education in curricular change as well as researchers in developing further change theories in complex adaptive health professions education systems.
Naturalizing skepticism
Authors: Jiménez‐Rolland Marc 
Published: July 2024

AbstractNaturalism, construed as the idea that philosophy should be continuous with science, is a highly influential view. Its consequences for epistemology, however, are rather odd. Many believe that naturalized epistemology allows eschewing traditional skeptical challenges. This is often seen as an advantage; but it also calls into question its claim of belonging to the philosophical inquiry into knowledge. This paper argues that skeptical challenges can be stated to defy epistemic optimism within naturalized epistemology, and that there are distinctively naturalistic forms of skepticism. To that end, it outlines some assumptions underlying many attempts to naturalize epistemology. It contrasts these approaches to traditional epistemology and identifies the reasons offered by naturalistic epistemologists to dismiss traditional skeptical challenges. Next, it argues that the problem of skepticism can be sensibly stated within a naturalistic setting. Finally, it contends that there are distinctively naturalistic strategies to argue for skepticism and diagnoses the prospects of naturalism vis‐à‐vis these kinds of skeptical challenges.
Learning to the rhythm: On the potential of music in fostering relations in the classroom
Authors: Gaillard JC , Gampell Anthony , Joe Martin , Skuse Zara , Young Caitlin 
Published: July 2024

AbstractThis article draws on a case study of a third‐year geography course to explore the potential of music in fostering relational pedagogy in higher education. We argue that the reciprocal nature of music sharing generates a dialogical space that allows for multiple relations to be developed between the learners and their selves, among students and peers, between learners and teachers, as well as between students and the materials they study and the wider world. Furthermore, music encourages an approach to pedagogy that is emancipatory and which is characterised by genuine care, humility and trust.
Music festival geographies: Place‐creation and attendee experience
Authors: Lindsay Neil , Kearns Robin , Coleman Tara 
Published: July 2024

AbstractWe examine how design features influence the experiences of attendees at New Zealand music festivals. Drawing on interviews with festival organisers and attendees, we argue that organisers configure particular atmospheres to provoke affective dispositions. By interrogating how festivals engage in this affective engineering, we argue that festivals are ephemeral spaces where design plays a central role in influencing the thoughts, feelings, behaviours and, ultimately, the place‐experience of attendees.
Knowledge Mapping of Macrophages in Osteoporosis: A Bibliometric Analysis (1999–2023)
Authors: Jia Hai‐Feng , Li Han‐Zheng , Rong Yi‐Fa , Jiang Kai , Liang Xue‐Zhen , Li Gang 
Published: July 2024

BackgroundOsteoporosis is a common metabolic disorder that significantly impacts quality of life in the elderly population. Macrophages play a crucial role in the development of osteoporosis by regulating bone metabolism through cytokine secretion. However, there is a lack of scholarly literature in the field of bibliometrics on this topic.ObjectiveThis study provides a detailed analysis of the research focus and knowledge structure of macrophage studies in osteoporosis using bibliometrics.MethodsThe scientific literature on macrophage research in the context of osteoporosis, retrieved from the Web of Science Core Collection (WoSCC) database spanning from January 1999 to December 2023, has been incorporated for bibliometric examination. The data is methodically analyzed and visually represented using analytical and visualization tools including VOSviewer, CiteSpace, Scimago Graphica, the Bibliometrix R package, and Pajek.Results and ConclusionsIn the last quarter‐century, there has been a consistent rise in the quantity of scholarly publications focusing on the relationship between macrophages and osteoporosis, resulting in a total of 1499 research documents. These studies have originated from 45 different countries, with China, South Korea, and the United States being the most prominent contributors, and the United States having the highest frequency of citations. Noteworthy research institutions involved in this field include Shanghai Jiao Tong University, Wonkwang University, Huazhong University of Science and Technology, and Seoul National University. The Journal of Bone and Mineral Research is widely regarded as the premier and most frequently referenced publication in the field. These publications involve the collaboration of 8744 authors, with Lee Myeung Su contributing the most articles, and Takayanagi being the most co‐cited author. Key emerging research focal points are encapsulated in keywords such as “mTOR,” “BMSCs,” “bone regeneration,” and “exosome.” The relationships between exosome from macrophage sources and those from BMSCs, along with the regulatory role of the mTOR signaling pathway on macrophages, represent crucial directions for future development in this field. This study represents the inaugural comprehensive bibliometric analysis detailing trends and advancements in macrophage research within the osteoporosis domain. It delineates recent frontiers and hotspots, providing valuable insights for researchers in this particular area of study.
Characterizing drug‐induced epidermal necrolysis in a pediatric cohort
Authors: Brown Ariel B. , Park Andrew J. , Agim Nnenna G. , Gordon Katherine A. 
Published: July 2024

AbstractThis study aims to characterize the timeline and clinical features of onset, progression, and management of drug‐induced epidermal necrolysis in pediatric patients. Sixteen pediatric patients were retrospectively identified and selected if under age 18 years at admission with one identified culprit drug exposure. Culprit drugs were antiepileptics (12/16, 75%) and antibiotics (4/16, 25%). Notably, anti‐epileptic drugs (AED) had delayed onset and reported dose escalations that precipitated symptom onset; thus, patients prescribed AED with or without planned dose escalations should be monitored for prodromal symptoms longer than the typical onset window.
Atypical cutaneous manifestations of methicillin resistant Staphylococcus aureus infections in two immunocompetent pediatric patients: Case reports and review of the literature
Authors: Bash Gina N. , Higgins Claire , McClanahan Danielle , Dunlap Rachel , Dhossche Julie , Leitenberger Sabra , Small Alison , Koon Stephanie Mengden , White Kevin P. , Funk Tracy 
Published: July 2024

AbstractAlthough many clinical variants of Staphylococcus aureus infection are well‐recognized, atypical presentations may mimic other conditions. We describe two cases of atypical S. aureus infections in pediatric patients: a S. aureus infection presenting with a vesicopustular rash mimicking varicella zoster virus and a case of multifocal panniculitis. Both of these cases were specifically caused by methicillin‐resistant S. aureus (MRSA). Additional cases of atypical S. aureus infections and presenting features from the current literature are also discussed.
Seeking peace and justice through harmony: Music and peacemaking
Authors: Hall Mitchell 
Published: July 2024

AbstractPeacemaking encompasses both positive efforts toward achieving a more just society and negative efforts to prevent or end violent conflicts and warfare. Popular music has often accompanied American peace and antiwar movements by arousing public concern for social justice, sustaining the hopes of activists, and challenging decision makers. This essay examines how musicians have made notable contributions to peace activism by addressing a diverse set of issues in American history.
How trustworthy is online dental information for individuals with Down syndrome from Ibero‐American countries?
Authors: Rey‐Otero G. , Diniz‐Freitas M. , Rivas‐Mundiña B. , Varela‐Aneiros I. , Sande‐López L. , Limeres‐Posse J. , García‐Mato E. 
Published: July 2024

AbstractBackgroundInternet has become an indispensable source of health‐related information. However, several studies have shown there to be a lack of quality control for webpages related to disability. Specifically, available content concerning Down syndrome (DS) and dentistry is limited and of dubious quality.ObjectiveThe aim of the present study was to assess the quality of online content in Spanish and Portuguese on dental care for individuals with DS.MethodsA simultaneous search in Google and Bing using the terms “Down syndrome” and “odontology/dentist/dental treatment” in Spanish and Portuguese was conducted in seven Ibero‐American countries (Argentina, Brazil, Chile, Colombia, Spain, Mexico, and Portugal). The first 100 consecutive pages of results from the three combinations of terms in each of the search engines were accessed and selected by applying conventional exclusion criteria. The selected pages were classified according to their authorship, specificity and dissemination potential. The quality of the online content was assessed using the DISCERN questionnaire and the Questionnaire to Evaluate Health Web Sites According to European Criteria (QEEC). The presence of the Health On Net (HON) and Accredited Medical Website (AMW) seals was also assessed.ResultsThe mean DISCERN score was 2.51 ± 0.85 and 2.57 ± 0.86 for the Spanish and Portuguese webpages, respectively. The mean readability score was 3.43 ± 1.26 and 3.25 ± 1.08 for the Spanish and Portuguese webpages, respectively. None of the selected webpages presented the HONcode or AMW trust seals.ConclusionsThe content available online in Spanish and Portuguese regarding Down syndrome and dentistry is scarce and of highly questionable quality.