bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparison of buffered and nonbuffered nasal saline irrigations in treating allergic rhinitis
Authors: Chusakul Supinda , Warathanasin Sukanya , Suksangpanya Naphorn , Phannaso Chuntima , Ruxrungtham Saran , Snidvongs Kornkiat , Aeumjaturapat Songklot 
Published: October 2012

AbstractObjectives/Hypothesis:We aimed to study the effect of alkalinity of isotonic nasal saline irrigation on nasal symptoms, mucociliary clearance, nasal patency, and patient's preference in patients with allergic rhinitis (AR).Study Design:A double‐blind, randomized, three‐arm crossover study.Methods:Patients with AR were enrolled. Three kinds of isotonic nasal saline irrigations: nonbuffered (pH 6.2–6.4), buffered with mild alkalinity (pH 7.2–7.4), and buffered with alkalinity (pH 8.2–8.4) were given one at a time, in different orders. Patients rinsed their nose with 240 ml of one solution twice daily for 10 days and then swapped to the others. The washout period was at least 5 days. Primary outcomes were nasal symptoms, mucociliary clearance time, and nasal patency. Outcomes were compared between baseline and posttreatment and also between various kinds of solution. Secondary outcomes were patients' preference and adverse events.Results:Thirty‐six subjects entered the study, and there were no dropouts. Overall nasal symptom was significantly improved from baseline (P = 0.03) only by buffered solution with mild alkalinity. Sneezing was significantly improved from baseline (P = 0.04) only by buffered solution with alkalinity. No other significant improvements were achieved by any solution. When comparing between the three nasal irrigations, there were no differences in all parameters. The patients significantly preferred the buffered solution with mild alkalinity (P = 0.02).Conclusions:Buffered isotonic saline with some degree of alkalinity may improve nasal symptoms. Isotonic saline irrigations, regardless of alkalinity, may not improve mucociliary function and nasal patency. Buffered isotonic saline with mild alkalinity is the most preferred. Laryngoscope, 2013
Diagnostic accuracy of history, laryngoscopy, and stroboscopy
Authors: Paul Benjamin C. , Chen Si , Sridharan Shaum , Fang Yixin , Amin Milan R. , Branski Ryan C. 
Published: October 2012

AbstractObjectives/Hypothesis:Although clinical dogma suggests the value of laryngeal visualization (flexible laryngoscopy and stroboscopy) in dysphonic patients, recently published clinical guidelines suggest that, in many cases, history and/or physical examination are sufficient to guide clinical decision‐making regarding the timing of such examinations. We sought to prospectively quantify the diagnostic accuracy of history, laryngoscopy, and stroboscopy using direct laryngoscopy as the gold standard.Study Design:Expert survey.Methods:Six laryngologists were presented with vignettes including history and physical examination (HPE), laryngosocpy, and stroboscopy. Questions regarding diagnosis, the certainty of diagnosis, and subsequent management plans were posed. Operative findings via direct laryngoscopy were employed as a comparator.Results:The diagnostic accuracy of HPE was quite low (5%). The accuracy of diagnosis increased substantially following laryngeal imaging; 68.3% for both flexible laryngoscopy and stroboscopy. Particular diagnoses were more consistently identified; cancer, for example, was much more accurately identified on laryngoscopy (100%) and stroboscopy (100%) rather than HPE alone (33%). Cancer was selected as the diagnosis in 10 of 60 HPEs, though was only correct once and missed in five cases. In contrast, no diagnoses of cancer were missed following laryngoscopic and/or stroboscopic examinations.Conclusion:These findings confirm the value of laryngeal visualization (flexible laryngoscopy and stroboscopy) in dysphonic patients, and the lack of accuracy of history and physical examination in determining the diagnosis in patients with hoarseness. Laryngoscope, 2013
Potential application of ocular and cervical vestibular‐evoked myogenic potentials in meniere's disease: A review
Authors: Young Yi‐Ho 
Published: October 2012

AbstractBy stimulating the ear with air‐conducted sound or bone‐conducted vibration stimuli, vestibular‐evoked myogenic potential (VEMP) can be recorded on the contracted neck muscles, termed cervical VEMP (cVEMP), and on the extraocular muscles, termed ocular VEMP (oVEMP). These two electrophysiological tests expand the test battery for clinicians to explore the dynamic otolithic function, adding a potential usefulness to the sacculocollic reflex and vestibulo‐ocular reflex, respectively. The inner ear test battery, including audiometry, and cVEMP, oVEMP and caloric tests, is designed for complete evaluation of the inner ear function, namely, the cochlea, saccule, utricle, and semicircular canals, respectively. Using this test battery to study the localization and prevalence of hydrops formation reveals that the declining function in the cochlea, saccule, utricle, and semicircular canals mimics the declining sequence of hydrops formation in temporal bone studies. This study reviewed the physiological results in Meniere's patients via the inner ear test battery, especially the potential application of the oVEMP and cVEMP tests, to correlate with the histopathological findings of Meniere's disease. Laryngoscope, 2012
Malignant melanoma induces migration and invasion of adult mesenchymal stem cells
Authors: Watts Tammara L. , Cui Ruwen 
Published: October 2012

AbstractObjectives/Hypothesis:To determine if melanoma cells secrete chemotactic factors that result in the migration of multipotent stem cells.Study Design:In vitro cell culture.Methods:Chemotaxis and invasion of human mesenchymal stem cells (hMSCs) was determined using the modified Boyden chamber assay. Quantification of growth factors secreted by melanoma cells (A375) was determined using enzyme‐linked immunosorbent assay.Results:Conditioned A375 melanoma media caused significant migration and invasion of hMSCs compared to serum‐free controls and conditioned media from normal melanocytes (P < .0001). The migratory effect appeared maximal after the A375 media was conditioned for 48 hours. Physiologically relevant concentrations of fibroblast growth factor‐2 (FGF2) (90 pg/mL) secreted by A375 melanoma cells caused significant migration of hMSCs (P < .001) compared to serum‐free and normal melanocyte controls. Neutralization of FGF2 inhibited the migration of hMSCs to that of the negative controls (conditioned media from normal melanocytes).Conclusions:The melanoma tumor microenvironment may be maintained through chemotaxis and invasion of multipotent hMSCs, and this migratory effect appears to be mediated in part through secretion of FGF2 by melanoma cells. Laryngoscope, 2012
Congenital neurocristic tumor of the head and neck
Authors: Patel Sapna , Rudzinski Erin , Perkins Jonathan 
Published: October 2012

AbstractNeurocristic tumors are rare growths with a predilection for the scalp region. These lesions have a highly variable appearance and an unpredictable course. Long‐term surveillance is recommended due to their potential for recurrence and possible malignant transformation into melanoma. The following is a report on congenital neurocristic tumor of the scalp and neck region. Laryngoscope, 2013
Current use of intralesional cidofovir for recurrent respiratory papillomatosis
Authors: Derkay Craig S. , Volsky Peter G. , Rosen Clark A. , Pransky Seth M. , McMurray J. Scott , Chadha Neil K. , Froehlich Patrick 
Published: October 2012

AbstractObjectives/Hypothesis:The authors sought to define the indications, administration, and adverse events associated with intralesional cidofovir use for recurrent respiratory papillomatosis (RRP).Study Design:Cross‐sectional study.Methods:A 21‐question online survey was distributed to 115 selected adult and pediatric laryngeal surgeons internationally. Results were used to draft statements of best practice, which were approved by the full membership of the RRP Task Force.Results:Eighty‐two surgeons, who altogether presently manage 3,043 patients with RRP, responded to the survey. Seventy‐four surgeons previously used cidofovir, reporting 1,248 patients in the last decade (estimated 801 adults and 447 children). Single indications for adjuvant cidofovir included six or more surgeries per year, increasing frequency of surgery, and extralaryngeal spread (in children). Most adult surgeons use 20 to 40 mg in <4 mL; pediatric surgeons use <20 mg in <2 mL. Scheduled administration following an initiation trial of five injections is common; cidofovir is discontinued following a complete response. Most surgeons biopsy routinely, use special informed consent, and are willing to participate in multi‐institutional clinical trials on cidofovir uses, efficacy, and safety.Conclusions:Eighteen statements were approved by the RRP Task Force after discussion of the survey results. Intralesional cidofovir may be initiated if surgical debulking is required every 2 to 3 months. The concept of an adjuvant regimen with regular biopsy is favored. Administration should remain below established safe limits of dosing (3 mg/kg) and volume. Informed consent, including discussion of off‐label use and acute kidney injury in children, is important. A special consent form sample is included. There remains a need for high‐quality data. Laryngoscope, 2013
The new database Seed Oil Fatty Acids (SOFA)
Authors: Matthäus Bertrand 
Published: October 2012

AbstractAfter more than three years the internet‐based database “Seed Oil Fatty Acids” (SOFA) is available again (http://sofa.mri.bund.de) free of charge after registration. This database is a unique collection of information about the fatty acid composition of wild plant seeds. The data were collected from the appropriate pharmaceutical, botanical and chemical literature over a period of more than 40 years. With financial assistance from the German Federal Ministry of Food, Agriculture and Consumer Protection via the lead partner Agency for Renewable Resources (FNR) the new database system based on mySQL and PHP as source language was created. Currently more than 18.000 different tables with about 130.000 individual data sets are searchable from the database. Additionally the database contains about 600 different fatty acids with more than 2.500 synonyms. The search for a defined (e. g. unusual or technically interesting) fatty acid or plant (family, genus, species) which contains this fatty acid is possible online. This search can be done by use of synonyms for the fatty acid (trivial name, systematic name) but also by using substructures of the fatty acid defined by an alpha‐numeric delta‐notation. It is possible to combine the search for different fatty acids by Boolean operators such as “AND” and “OR”. This paper gives an overview about the application of the different search forms and provides search examples.
Bio‐based adipic acid from renewable oils
Authors: Beardslee Thomas , Picataggio Stephen 
Published: October 2012

AbstractAdipic acid (hexanedioic acid, C6H10O4) is a high‐volume dicarboxylic acid used as a chemical intermediate in the commercial manufacture of nylon 6,6, thermoplastic polyurethane resins, plasticizers, adhesives and synthetic lubricants, with an estimated global market worth approximately $6.3 billion. We report here the development of a robust industrial yeast strain and fermentation process for production of bio‐based adipic acid at high yield and selectivity from any vegetable oil, regardless of its fatty acid composition. Bio‐based adipic acid could alleviate many of the drawbacks associated with adipic acid produced from petrochemical sources and offer a sustainable alternative to benzene price swings as well as a significant reduction in greenhouse gas emissions.
Influence of gut microbiota and manipulation by probiotics and prebiotics on host tissue fat: Potential clinical implications
Authors: Wall Rebecca , Ross Paul R. , Shanahan Fergus , Quigley Eamonn M , Dinan Timothy G. , Cryan John F. , Fitzgerald Gerald F. , Stanton Catherine 
Published: October 2012

AbstractThe gut microbiota is considered as one of the most important environmental factors impacting on host metabolism, contributing to variations in body weight, fat distribution, insulin sensitivity and lipid metabolism. Modification of the gut microbiota by dietary interventions such as probiotics and prebiotics may favourably affect host lipid metabolism. We have shown that microbial metabolism in the gut, and its manipulation by administered microbes can influence fatty acid composition of a number of organs in the host. Furthermore, a prebiotic approach was shown to alter polyunsaturated fatty acids in white adipose tissue. Although a deeper knowledge of the interactions between members of the gut microbiota and fatty acids is needed, nutritional modulation of this complex community may represent a realistic target for modification of host fatty acid composition.
Methoxypoly(ethylene glycol)‐block‐Poly(L‐glutamic acid)‐Loaded Cisplatin and a Combination With iRGD for the Treatment of Non‐Small‐Cell Lung Cancers
Authors: Song Wantong , Li Mingqiang , Tang Zhaohui , Li Quanshun , Yang Yan , Liu Huaiyu , Duan Taicheng , Hong Hua , Chen Xuesi 
Published: October 2012

AbstractCDDP is loaded into methoxypoly(ethylene glycol)‐block‐poly(L‐glutamic acid) (mPEG‐b‐PLG), and a combination with iRGD is applied for NSCLC chemotherapy. The CDDP‐loaded micelles show sustained cisplatin release in PBS, dose‐ and time‐dependent inhibition to HeLa and A549 cell proliferation, and no apparent hemolysis activities. In in vivo studies using subcutaneous NSCLC xenograft models (A549), both free CDDP and CDDP‐loaded micelles show an evident anti‐tumor effect. However, the toxicity of CDDP is significantly reduced in the cases of CDDP‐loaded micelles and co‐administration with iRGD, and the survival time is prolonged by over 30%. Therefore, mPEG‐b‐PLG‐loaded cisplatin and the combination with iRGD provides a promising new therapy for NSCLC. magnified image
Effects of pH value and temperature of solution on the removal efficiency of support material
Authors: Kuo C.‐C. , Tsou Y.‐C. 
Published: October 2012

AbstractRemoving support material from rapid prototyping part fabricated by fused deposition modeling is required when the object is completed. Removing support material from rapid prototyping part system rapidly and efficiently is an important concern because the product life cycle is shorter than before. Effects of pH value and temperature of solution on the removal efficiency of support material were investigated in this study. Both pH value and temperature of the solution contribute to the removal efficiency of support material. The saving in the removing time of up to 83.4% is achieved by integrating two effects. The trend equation of y = 293.42x + 544.72 is capable of predicting the removing time. Removing time (y) can be predicted directly from the volume of support material (x). The error rate can be controlled within 5.11%. Surface roughness improvement rate of up to 46.3% is achieved using the solution with a pH value of 13 and a temperature of 95°C.
Study on contact stresses of un‐stepped rounded D‐ring under uniform squeeze rate and internal pressure by photoelastic experimental hybrid method
Authors: Mose B. R. , Hawong J.‐S. 
Published: October 2012

AbstractThe stresses that occur in an un‐stepped rounded D‐ring loaded with various internal pressures and compressed to a 20% squeeze rate are analyzed using photoelastic experimental hybrid method. The analysis shows that the contact stresses on both the upper and front sides of the D‐ring increase as the applied internal pressure increases with the magnitudes of σX and σY being considerably higher than those of τXY. At a pressure of zero and 20% compression, the isochromatic fringe patterns of the un‐stepped D‐ring are almost symmetrical. However, as the internal pressure applied to the D‐ring increases the isochromatic fringe patterns shift and curve smoothly towards the extrusion gap making the upper and front sides to be more stressed than the lower side. At a pressure of 1.96 MPa and above, the contact stresses on the upper side were found to be almost constant along the contact length. By supplying a fillet radius of 2.1 mm at the corners of the un‐stepped D‐ring the high stresses at the corners were reduced by up to 45%. The results from the study further demonstrated that the un‐stepped rounded D‐ring with a ratio of r/d = 0.3 to be can be an alternative choice to the O‐ring for sealing applications. Interestingly, the pressures that the un‐stepped D‐ring can withstand before extrusion are higher than those of an O‐ring.
Are transversus abdominis/oblique internal and pelvic floor muscles coactivated during pregnancy and postpartum?
Authors: Pereira Larissa Carvalho , Botelho Simone , Marques Joseane , Amorim Cesar Ferreira , Lanza Ana Helena , Palma Paulo , Riccetto Cassio 
Published: October 2012

AbstractAimThe aim of this study was to simultaneously evaluate both transversus abdominis/internal oblique (Tra/IO) and pelvic floor muscles (PFM) during isometric exercises in nulliparous, pregnant, and postpartum women.MethodsThe study included 81 women divided into four groups: (G1) nulliparous women without urinary symptoms (n = 20); (G2) primigravid pregnant women with gestational age ≥24 weeks (n = 25); (G3) primiparous postpartum women after vaginal delivery with right mediolateral episiotomy (n = 19); (G4) primiparous postpartum women after cesarean section delivery, with 40 to 60 days of postpartum (n = 17). The assessment consisted of simultaneous surface electromyography (EMGs) of the PFM and Tra/IO, during three isometric maximum voluntary contractions.ResultsOnly nulliparous women presented significant simultaneous Tra/IO and PFM co‐activation when asked to contract PFM (P = 0.0007) or Tra/IO (P = 0.00001).ConclusionsThere is co‐activation of the transversus abdominis/internal oblique and the pelvic floor muscles in young, asymptomatic nulliparous women. This pattern was modified in primigravid pregnant and primiparous postpartum women regardless of the delivery mode. Neurourol. Urodynam. 32: 416–419, 2013. © 2012 Wiley Periodicals, Inc.
Indwelling urinary catheterization after acute stroke
Authors: Wu Chun‐Hsien , Tseng Mei‐Chiun , Chen Yu‐Wei , Sung Sheng‐Feng , Yeh Poh‐Shiow , Lin Huey‐Juan 
Published: October 2012

AbstractAimsProlonged indwelling urinary catheterization (IUC) increases risk of urinary tract infection. We aimed to investigate the incidence and risk factors associated with IUC following acute stroke, and its impact on stroke outcome.MethodsWe prospectively enrolled stroke patients hospitalized within 10 days after onset from August 2006 to December 2008. Kaplan–Meier method was used to estimate the cumulative incidence of IUC, and Cox regression analysis to evaluate the independent predictors. The impact of IUC on poor outcome (modified Rankin Scale >2 or dead) at 3 months was studied by logistic regression.ResultsOf 2,803 patients, 697 (25%) received indwelling urinary catheters. Catheterization was carried out mostly within 1–2 days of admission (86%), with estimated cumulative incidence of 13% (95% confidence interval, 11–14%) at 2 days in patients with ischemic stroke (IS), and 57% (53–61%) in patients with intracerebral hemorrhage (ICH). In IS patients, IUC was significantly associated with increasing age, baseline stroke severity, and neurological deterioration. In ICH patients, stroke severity on admission was the only significant predictor after adjustment. We assessed the 3‐month outcome in 2,388 patients, after excluding 177 (6%) dead at discharge, 164 (6%) without providing informed consent, and 74 (3%) lost to follow‐up. IUC during acute hospitalization was significantly associated with unfavorable 3‐month outcome after adjustment.ConclusionsIUC was common in acute stroke care and associated with unfavorable outcome at 3 months. Whether judicious use of urinary catheters in acute stroke patients would improve outcomes may warrant further studies. Neurourol. Urodynam. 32: 480–485, 2013. © 2012 Wiley Periodicals, Inc.
Dynamic three‐dimensional imaging of phosphocreatine recovery kinetics in the human lower leg muscles at 3T and 7T: a preliminary study
Authors: Parasoglou Prodromos , Xia Ding , Chang Gregory , Regatte Ravinder R. 
Published: October 2012

The rate of phosphocreatine (PCr) resynthesis after physical exercise has been extensively studied with phosphorus (31P)‐MRS. Previous studies have used small surface coils that were limited to measuring one superficial muscle per experiment. This study focuses on the development and implementation of a spectrally selective three‐dimensional turbo spin echo (3D‐TSE) sequence at 3T and 7T with temporal resolution of 24 s, using two geometrically identical volume coils. We acquired imaging data of PCr recovery from four healthy volunteers and one diabetic patient, who performed plantar flexions using resistance bands. We segmented the anatomical regions of six different muscles from the lower leg, namely the gastrocnemius [lateral (GL) and medial (GM)], the tibialis [anterior (TA) and posterior (TP)], the soleus (S) and the peroneus (P) and measured the local PCr resynthesis rate constants. During the same examination, we also acquired unlocalized 31P‐MRS data at a temporal resolution of 6 s.At 3T, the PCr resynthesis rate constants were measured at 25.4 ± 3.7 s [n = 4, mean ± standard deviation (SD)] using the MRS method and 25.6 ± 4.4 s using the MRI method. At 7T, the measured rates were 26.4 ± 3.2 s and 26.2 ± 4.7 s for MRS and MRI. Using our imaging method, we measured the local PCr resynthesis rate constants in six individual muscles of the lower leg (min/max 20.2/31.7 s). The recovery rate constants measured for the diabetic patient were 55.5 s (MRS) and 52.7 s (MRI).The successful implementation of our 3D‐method suggests that imaging is possible at both fields with a relatively high spatial resolution (voxel size: 4.2 mL at 3T and 1.6 mL at 7T) using volume coils and that local PCr resynthesis rates can be obtained in a single measurement. The advantage of the imaging method is that it can highlight differences in PCr resynthesis rates between different muscles in a single measurement in order to study spatial gradients of metabolic properties of diseased states for which very little is currently known. Copyright © 2012 John Wiley & Sons, Ltd.