bluuebunny/crossref_metadata_2025_split huggingface dataset:
Experimental and Mathematical Investigation of Thermochemical Conversion for Horse Manure
Authors: Maache Mohamed , Kada Cheikh , Amano Ryoichi S. , Kumano Hiroyuki , Selim Osama M. , Kada Kada 
Published: July 2024

Abstract
Horse manure is one of the highest potential biowastes for heat and power generation. This article investigates the experimental and mathematical modeling of thermochemical conversion for horse manure. As one type of thermochemical conversions, the pyrolysis process was carried out at eight different heating rates on horse manure using three parameters: the extent of reaction, the rate change of the extent of reaction, and differential thermal analysis (DTA), all used to determine kinetic data that will be validated with a mathematical model. Slow pyrolysis: below 15 °C/min showed optimistic results of obtaining exothermic reaction over a wide range of temperature which makes it self-sustainable with steady heat generation. Also, low heating rates allowed a quasi-equilibrium state through slow heating with a minimum delay in response for any transient error that could be generated from differential thermal gravimetry (DTG) device.
Active Constrained Layer Damping of Beams With Natural Fiber Reinforced Viscoelastic Composites
Authors: Mishra Vibhooti N. , Sarangi Saroj Kumar 
Published: July 2024

Abstract
Viscoelastic composite reinforced with natural fibers is proposed here for the damping treatment of structures for vibration attenuation. The constrained layer damping (CLD) method is found a prominent structural vibration damping method and as a result of the inclusion of natural fiber, substantial damping could be achieved due to the development of shear as well as extensional strains in the viscoelastic material. Finite element analysis of a substrate beam combined with CLD treatment is used to investigate the corresponding improvement in damping. The influence of various geometry of presently considered natural viscoelastic composite layers on the CLD treatment's damping performance has been evaluated and discussed. Damping performances of natural as well as synthetic fibers have been assessed and compared for using natural fibers in viscoelastic composite for various structural applications. The addition of natural fiber has resulted from enhanced damping capacity due to substantial friction at the natural fiber–matrix interface compared to the case of interface with synthetic fiber. Natural fiber attributes less stiffness and a higher loss factor as compared to synthetic fiber and the insertion of stiff fibers affects the polymer chain's movements, decreasing the matrix phase's damping behavior. The dynamic mechanical analysis test is performed to evaluate the damping characteristics in the form of loss factor, storage, and loss modulus over the temperature range from frozen state to melting state.
An Investigation of Tensile, Fatigue, and Fracture Behavior of 3D-Printed Polymers
Authors: Rahman M. Shafiqur , Alam Chowdhury Sadid , Pulok Mohammad Khairul Habib , Zeng Congyuan , Chakravarty Uttam K. 
Published: July 2024

Abstract
The progression of manufacturing technology has significantly benefited from the adoption of 3D printing techniques, which enable the production of parts with intricate geometries. However, it is important to acknowledge that components fabricated through this additive manufacturing method frequently manifest defects and are prone to failure under severe conditions. Therefore, a thorough examination of the mechanical properties of these parts is essential to effectively reduce the failure. This study aimed to explore the mechanical properties of two prevalently used 3D-printed polymers, specifically Onyx and acrylonitrile butadiene styrene (ABS), by integrating computational and experimental analyses. The experimental study utilized a material testing system and digital image correlation (DIC) technology, while the computational analysis covered the finite element (FE) modeling of the 3D-printed samples. The research focused on evaluating the tensile strength and fatigue resistance of the specimens printed in various orientations, alongside a detailed investigation of their fracture behavior. The crack propagation analysis was carried out using the DIC system and the separating morphing and adaptive re-meshing technology (SMART) scheme in ansys. It was observed that upright build orientation produced the weakest samples for axial loading and specimens with notches failed earlier than those without. Moreover, Onyx was found to have a higher resistance to fracture or failure compared to ABS. The FE modeling results demonstrated strong agreement with the experimental results, validating their accuracy and reliability in characterizing the critical mechanical response of 3D-printed parts rapidly and cost effectively.
Dietary fiber monosaccharide content alters gut microbiome composition and fermentation
Authors: Jensen Nick , Maldonado-Gomez Maria , Krishnakumar Nithya , Weng Cheng-Yu , Castillo Juan , Razi Dale , Kalanetra Karen , German J. Bruce , Lebrilla Carlito B. , Mills David A. , Taft Diana H. 
Published: July 2024

ABSTRACT

Members of the mammalian gut microbiota metabolize diverse complex carbohydrates that are not digested by the host, which are collectively labeled “dietary fiber.” While the enzymes and transporters that each strain uses to establish a nutrient niche in the gut are often exquisitely specific, the relationship between carbohydrate structure and microbial ecology is imperfectly understood. The present study takes advantage of recent advances in complex carbohydrate structure determination to test the effects of fiber monosaccharide composition on microbial fermentation. Fifty-five fibers with varied monosaccharide composition were fermented by a pooled feline fecal inoculum in a modified MiniBioReactor array system over a period of 72 hours. The content of the monosaccharides glucose and xylose was significantly associated with the reduction of pH during fermentation, which was also predictable from the concentrations of the short-chain fatty acids lactic acid, propionic acid, and the signaling molecule indole-3-acetic acid. Microbiome diversity and composition were also predictable from monosaccharide content and SCFA concentration. In particular, the concentrations of lactic acid and propionic acid correlated with final alpha diversity and were significantly associated with the relative abundance of several of the genera, including
Lactobacillus
and
Dubosiella
. Our results suggest that monosaccharide composition offers a generalizable method to compare any dietary fiber of interest and uncover links between diet, gut microbiota, and metabolite production.

IMPORTANCE
The survival of a microbial species in the gut depends on the availability of the nutrients necessary for that species to survive. Carbohydrates in the form of non-host digestible fiber are of particular importance, and the set of genes possessed by each species for carbohydrate consumption can vary considerably. Here, differences in the monosaccharides that are the building blocks of fiber are considered for their impact on both the survival of different species of microbes and on the levels of microbial fermentation products produced. This work demonstrates that foods with similar monosaccharide content will have consistent effects on the survival of microbial species and on the production of microbial fermentation products.
Genetic diversity accelerates canine distemper virus adaptation to ferrets
Authors: Siering Oliver , Langbein Mareike , Herrmann Maike , Wittwer Kevin , von Messling Veronika , Sawatsky Bevan , Pfaller Christian K. 
Published: July 2024

ABSTRACT

RNA viruses adapt rapidly to new host environments by generating highly diverse genome sets, so-called “quasispecies.” Minor genetic variants promote their rapid adaptation, allowing for the emergence of drug-resistance or immune-escape mutants. Understanding these adaptation processes is highly relevant to assessing the risk of cross-species transmission and the safety and efficacy of vaccines and antivirals. We hypothesized that genetic memory within a viral genome population facilitates rapid adaptation. To test this, we investigated the adaptation of the Morbillivirus canine distemper virus to ferrets and compared an attenuated, Vero cell-adapted virus isolate with its recombinant derivative over consecutive ferret passages. Although both viruses adapted to the new host, the reduced initial genetic diversity of the recombinant virus resulted in delayed disease onset. The non-recombinant virus gradually increased the frequencies of beneficial mutations already present at very low frequencies in the input virus. In contrast, the recombinant virus first evolved
de novo
mutations to compensate for the initial fitness impairments. Importantly, while both viruses evolved different sets of mutations, most mutations found in the adapted non-recombinant virus were identical to those found in a previous ferret adaptation experiment with the same isolate, indicating that mutations present at low frequency in the original virus stock serve as genetic memory. An arginine residue at position 519 in the carboxy terminus of the nucleoprotein shared by all adapted viruses was found to contribute to pathogenesis in ferrets. Our work illustrates the importance of genetic diversity for adaptation to new environments and identifies regions with functional relevance.

IMPORTANCE
When viruses encounter a new host, they can rapidly adapt to this host and cause disease. How these adaptation processes occur remains understudied. Morbilliviruses have high clinical and veterinary relevance and are attractive model systems to study these adaptation processes. The canine distemper virus is of particular interest, as it exhibits a broader host range than other morbilliviruses and frequently crosses species barriers. Here, we compared the adaptation of an attenuated virus and its recombinant derivative to that of ferrets. Pre-existing mutations present at low frequency allowed faster adaptation of the non-recombinant virus compared to the recombinant virus. We identified a common point mutation in the nucleoprotein that affected the pathogenesis of both viruses. Our study shows that genetic memory facilitates environmental adaptation and that erasing this genetic memory by genetic engineering results in delayed and different adaptation to new environments, providing an important safety aspect for the generation of live-attenuated vaccines.
Service development project to pilot a digital technology innovation for video direct observation of therapy in adult patients with asthma
Authors: O’Neill Katherine , Gormley Cairine , Kelly Martin G , Huey Rachel , Fleming Glenda , Scott Michael , Shields Michael , McElnay James C 
Published: July 2024

BackgroundAdherence to pharmacotherapy and use of the correct inhaler technique are important basic principles of asthma management. Video- or remote-direct observation of therapy (v-DOT) could be a feasible approach to facilitate monitoring and supervising therapy, supporting the delivery of standard care.ObjectiveTo explore the utility and the feasibility of v-DOT to monitor inhaler technique and adherence to treatment in adults attending the asthma outpatient service in a tertiary hospital in Northern Ireland.MethodThe project evaluated use of the technology with 10 asthma patients. Patient and clinician feedback was obtained, in addition to measures of patient engagement and disease-specific clinical markers to assess the feasibility and utility of v-DOT technology in this group of patients.ResultsThe engagement rate with v-DOT for participating patients averaged 78% (actual video uploads vs expected video uploads) over a median 7 week usage period. Although 50% of patients reported a technical issue at some stage during the usage period, all patients and clinicians reported that the technology was easy to use and that they were satisfied with the outcomes. A range of positive impacts were observed, including optimised inhaler technique and an observed improvement in lung function. An increase in asthma control test scores aligned with clinical aims to promote adherence and alleviate symptoms.ConclusionThe v-DOT technology was shown to be a feasible method of assessing inhaler technique and monitoring adherence in this small group of adult asthma patients. A range of positive impacts for participating patients and clinicians were observed. Not all patients invited to join the project agreed to participate or engage with using the technology, highlighting that in this setting, digital modes of delivering care provide only one of the approaches in the necessary “tool kit” for clinicians and patients.
Fulfilling last wishes: improving the compassionate discharge process
Authors: Alias Rasidah , Neo Yi Ling , Wang Liyun , Sie Long Zhen , Goh Hwee Jin , Mohamed Hussein Mohamed Yazid , Abdullah Hasnah , Wong Yoke Ping 
Published: July 2024

BackgroundCompassionate discharges (ComD), commonly known as rapid discharges, are urgent one-way discharges for critically ill hospitalised patients with death expected within hours or less than 7 days, to die at their place of choice—usually in their own home. Challenges abound in this time-sensitive setting when multiple parties must work together to prepare medically unstable patients for discharge, yet healthcare staff are largely unaware of the process, resulting in delays.MethodsProcess mapping, an Ishikawa diagram and a Pareto chart were used to identify barriers, which included timely acquisition of home equipment and medication and poor communication among stakeholders. In May 2020, the Quality Improvement (QI) team embarked on a pilot project to reduce family caregiver anxiety and delays in the ComD process while maintaining a success rate above 90% over a 12-month period.InterventionsThree Plan-Do-Study-Act (PDSA) cycles were used to refine a ComD resource package that was developed; this consisted of a checklist, a kit and caregiver resources. This was to support nurses, doctors and families during this difficult and emotional transition. Items in the ComD resource package were revised iteratively based on user feedback, with further data collected to measure its usefulness.ResultsThe 12-month ComD success rate over 3 PDSA cycles were 88.9%, 94.2% and 96.7%, respectively, after each cycle. There was a consistent reduction in the level of family anxiety before and after caregiver training and resources. Reasons for failed ComD included acute clinical deterioration or delays in obtaining home oxygen support.ConclusionThe ComD resource package allowed collaborative work across different disciplines, strengthening the safety and utility of ComD and allowing patients to die in their place of choice. These are ubiquitous across settings; this QI problem is thus relevant beyond our local institution.
Factors associated with decreased anal sphincter tone and the accuracy of forced anal examinations to detect individuals having receptive anal intercourse: an observational study
Authors: Nyitray Alan G , Rosser B R Simon , Hazra Aniruddha , Nitkowski Jenna , Smith Derek , Brzezinski Bridgett , Ridolfi Timothy J , Schneider John A , Chiao Elizabeth Y , Sanos Sandrine , Mkonyi Ever , Mgopa Lucy , Ross Michael W 
Published: July 2024

Introduction
Forced anal examinations are used to prosecute sexual and gender minorities (SGM) in multiple countries under the presumption that decreased sphincter tone, assessed by a finger inserted into the anal canal, can detect persons practising receptive anal intercourse. Using baseline data from a longitudinal study, we aimed to determine factors associated with sphincter tone and the accuracy of sphincter tonality to detect persons engaging in receptive anal intercourse.

Methods
Clinicians in Chicago, Houston and Milwaukee, USA conducted digital anal rectal examinations (DARE) to score sphincter resting tone (RT) and squeeze tone (ST). On a separate survey, individuals reported their preferred position for anal intercourse, that is, either always/mostly insertive anal intercourse, always/mostly receptive anal intercourse or both receptive and insertive anal intercourse. Multivariable regression assessed factors associated with decreased sphincter tone while the area under the receiver operating characteristic curves (AUC) estimated the accuracy of sphincter tonality to detect receptive anal intercourse.

Results

Of 838 participants, 94.0% of whom were cisgendered males, 11.3% had decreased RT (95/838) and 6.3% had decreased ST (53/838). The accuracy of DARE to detect any receptive anal intercourse was little better than random guessing (AUC 0.53, 95% CI 0.51 to 0.55 and AUC 0.51, 95% CI 0.49 to 0.53, respectively). RT and ST decreased with age regardless of sexual behaviour (p
trend
<0.01 for both). Compared with individuals having always/mostly insertive anal intercourse, individuals having always/mostly receptive anal intercourse were associated with decreased RT, but not ST, while those equally preferring both insertive and receptive anal intercourse were not associated with decreased RT or ST.

Conclusion
Decreased sphincter tone is uncommon among SGM who prefer receptive anal intercourse. Given virtually no accuracy, a finger inserted into the anus has no utility to detect individuals practising receptive anal intercourse and thus should not be used as such.

Trial registration number

NCT04090060
.
High-flow nasal oxygen therapy compared with conventional oxygen therapy in hospitalised patients with respiratory illness: a systematic review and meta-analysis
Authors: Seow Daniel , Khor Yet H , Khung Su-Wei , Smallwood David M , Ng Yvonne , Pascoe Amy , Smallwood Natasha 
Published: July 2024

BackgroundHigh-flow nasal oxygen therapy (HFNO) is used in diverse hospital settings to treat patients with acute respiratory failure (ARF). This systematic review aims to summarise the evidence regarding any benefits HFNO therapy has compared with conventional oxygen therapy (COT) for patients with ARF.MethodsThree databases (Embase, Medline and CENTRAL) were searched on 22 March 2023 for studies evaluating HFNO compared with COT for the treatment of ARF, with the primary outcome being hospital mortality and secondary outcomes including (but not limited to) escalation to invasive mechanical ventilation (IMV) or non-invasive ventilation (NIV). Risk of bias was assessed using the Cochrane risk-of-bias tool (randomised controlled trials (RCTs)), ROBINS-I (non-randomised trials) or Newcastle-Ottawa Scale (observational studies). RCTs and observational studies were pooled together for primary analyses, and secondary analyses used RCT data only. Treatment effects were pooled using the random effects model.Results63 studies (26 RCTs, 13 cross-over and 24 observational studies) were included, with 10 230 participants. There was no significant difference in the primary outcome of hospital mortality (risk ratio, RR 1.08, 95% CI 0.93 to 1.26; p=0.29; 17 studies, n=5887) between HFNO and COT for all causes ARF. However, compared with COT, HFNO significantly reduced the overall need for escalation to IMV (RR 0.85, 95% CI 0.76 to 0.95 p=0.003; 39 studies, n=8932); and overall need for escalation to NIV (RR 0.70, 95% CI 0.50 to 0.98; p=0.04; 16 studies, n=3076). In subgroup analyses, when considering patients by illness types, those with acute-on-chronic respiratory failure who received HFNO compared with COT had a significant reduction in-hospital mortality (RR 0.58, 95% CI 0.37 to 0.91; p=0.02).DiscussionHFNO was superior to COT in reducing the need for escalation to both IMV and NIV but had no impact on the primary outcome of hospital mortality. These findings support recommendations that HFNO may be considered as first-line therapy for ARF.PROSPERO registration numberCRD42021264837.
Evaluation of the impact of artificial intelligence-assisted image interpretation on the diagnostic performance of clinicians in identifying pneumothoraces on plain chest X-ray: a multi-case multi-reader study
Authors: Novak Alex , Ather Sarim , Gill Avneet , Aylward Peter , Maskell Giles , Cowell Gordon W , Espinosa Morgado Abdala Trinidad , Duggan Tom , Keevill Melissa , Gamble Olivia , Akrama Osama , Belcher Elizabeth , Taberham Rhona , Hallifax Rob , Bahra Jasdeep , Banerji Abhishek , Bailey Jon , James Antonia , Ansaripour Ali , Spence Nathan , Wrightson John , Jarral Waqas , Barry Steven , Bhatti Saher , Astley Kerry , Shadmaan Amied , Ghelman Sharon , Baenen Alec , Oke Jason , Bloomfield Claire , Johnson Hilal , Beggs Mark , Gleeson Fergus 
Published: July 2024

BackgroundArtificial intelligence (AI)-assisted image interpretation is a fast-developing area of clinical innovation. Most research to date has focused on the performance of AI-assisted algorithms in comparison with that of radiologists rather than evaluating the algorithms’ impact on the clinicians who often undertake initial image interpretation in routine clinical practice. This study assessed the impact of AI-assisted image interpretation on the diagnostic performance of frontline acute care clinicians for the detection of pneumothoraces (PTX).MethodsA multicentre blinded multi-case multi-reader study was conducted between October 2021 and January 2022. The online study recruited 18 clinician readers from six different clinical specialties, with differing levels of seniority, across four English hospitals. The study included 395 plain CXR images, 189 positive for PTX and 206 negative. The reference standard was the consensus opinion of two thoracic radiologists with a third acting as arbitrator. General Electric Healthcare Critical Care Suite (GEHC CCS) PTX algorithm was applied to the final dataset. Readers individually interpreted the dataset without AI assistance, recording the presence or absence of a PTX and a confidence rating. Following a ‘washout’ period, this process was repeated including the AI output.ResultsAnalysis of the performance of the algorithm for detecting or ruling out a PTX revealed an overall AUROC of 0.939. Overall reader sensitivity increased by 11.4% (95% CI 4.8, 18.0, p=0.002) from 66.8% (95% CI 57.3, 76.2) unaided to 78.1% aided (95% CI 72.2, 84.0, p=0.002), specificity 93.9% (95% CI 90.9, 97.0) without AI to 95.8% (95% CI 93.7, 97.9, p=0.247). The junior reader subgroup showed the largest improvement at 21.7% (95% CI 10.9, 32.6), increasing from 56.0% (95% CI 37.7, 74.3) to 77.7% (95% CI 65.8, 89.7, p<0.01).ConclusionThe study indicates that AI-assisted image interpretation significantly enhances the diagnostic accuracy of clinicians in detecting PTX, particularly benefiting less experienced practitioners. While overall interpretation time remained unchanged, the use of AI improved diagnostic confidence and sensitivity, especially among junior clinicians. These findings underscore the potential of AI to support less skilled clinicians in acute care settings.