bluuebunny/crossref_metadata_2025_split huggingface dataset:
Improving Patient Safety of Acute Care Lumbar Punctures
Authors: Ormerod Victoria 
Published: May 2014

AbstractLumbar puncture (LP) is a common invasive procedure in the acute medical setting but is not without its risks and complications, making best clinical practice and correct documentation important for patient safety. Previous audit revealed poor levels of consistency in technique and documentation in the acute medical setting, highlighting it as an area for improvement.This project aims to identify current levels of documentation and improve upon these through the departmental education and the introduction of a documentation tool to create a safer clinical environment for LPs. Gold standards in clinical practice were identified through literature review and national guidelines, establishing 15 key parameters as essential areas for documentation.Patient notes were retrospectively analysed after LP over a two month period to identify levels of documentation in these areas, and the clinical technique used. Results of this initial audit were presented to the department along with an education session regarding current evidence based best practice for LPs and the important aspects relating to patient safety. A documentation tool was also introduced. A re-audit was then performed of the same parameters and assessing the use of the documentation tool.Results showed a significant increase in overall documentation from 44% up to 95% after intervention, with 85% of cases using the new proforma. We can conclude that the introduction of a documentation tool and departmental education has significantly improved upon LP documentation in the acute medical setting. This is important for both the protection of medical professionals, as well as patient safety and quality of care, and could be implemented in other clinical environments.
Socioeconomic position and the association between anticipated and actual survival in older English adults
Authors: Adams Jean , Stamp Elaine , Nettle Daniel , Milne Eugene M G , Jagger Carol 
Published: May 2014

BackgroundSocioeconomic disadvantage may cause individuals to have lower expectations of longevity and not engage in healthy behaviours because they judge the long-term health benefits of these to be minimal.We explored demographic, health behaviour, health and socioeconomic correlates of subjectively estimated lifespan (‘anticipated survival’); the ability of anticipated survival to predict actual survival; and whether the predictive ability of anticipated survival differed by other variables, particularly socioeconomic position.MethodsData were from wave 1 of the English Longitudinal Study of Ageing. Anticipated survival for up to 25 years was measured on a scale of 0–100. Actual survival was measured over a mean of 6 years, and socioeconomic position using education, household income, occupational class and area deprivation.ResultsOf 10 768 participants, 2255 (21%) died during follow-up. Anticipated survival was positively associated with socioeconomic position, and was greater in women, younger individuals, non-smokers and those who were not widowed, consumed more alcohol, were more physically active, and reported better physical and mental health. After full adjustment, anticipated survival remained positively associated with actual survival. Those reporting low anticipated survival were more likely to die over time than those reporting moderate anticipated survival (HR (95% CIs 1.11 (1.00 to 1.23). The relationship differed significantly by income and age, being strongest in younger individuals and those with higher household income.ConclusionsAnticipated survival varied with other variables as expected and reflected actual survival. Younger individuals and those with higher household income were better able to identify subtle differences associated with actual survival.
Analysis of hemodynamics and wall mechanics at sites of cerebral aneurysm rupture
Authors: Cebral Juan R , Vazquez Mariano , Sforza Daniel M , Houzeaux Guillaume , Tateshima Satoshi , Scrivano Esteban , Bleise Carlos , Lylyk Pedro , Putman Christopher M 
Published: May 2014

BackgroundIt is thought that aneurysms evolve as the result of progressive degradation of the wall in response to abnormal hemodynamics characterized by either high or low wall shear stress (WSS).ObjectiveTo investigate the effects of these two different hemodynamic pathways in a series of cerebral aneurysms with known rupture sites.MethodsNine aneurysms in which the rupture site could be identified in three-dimensional images were analyzed. The WSS distribution was obtained from computational fluid dynamics (CFD) simulations. Internal wall stresses were computed using structural wall models under hemodynamic loads determined by the CFD models. Wall properties (thickness and stiffness) were modulated with the WSS distribution (increased or decreased in regions of high or low WSS) to test possible wall degradation pathways. Rupture probability indices (RPI) were calculated to compare different wall models.ResultsMost rupture sites aligned with the intrasaccular flow stream and downstream of the primary impaction zone. The model that best explained the rupture site (produced higher RPI) in eight of the nine aneurysms (89%) had thinner and stiffer walls in regions of abnormally high WSS. The remaining case (11%) was best explained by a model with thinner and stiffer walls in regions of abnormally low WSS.ConclusionsAneurysm rupture seems to be caused by localized degradation and weakening of the wall in response to abnormal hemodynamics. Image-based computational models assuming wall thinning and stiffening in regions of abnormally high WSS were able to explain most of the observed rupture sites.
Circulating Tumor Cells: A Multifunctional Biomarker
Authors: Yap Timothy A. , Lorente David , Omlin Aurelius , Olmos David , de Bono Johann S. 
Published: May 2014

AbstractOne of the most promising developments in translational cancer medicine has been the emergence of circulating tumor cells (CTC) as a minimally invasive multifunctional biomarker. CTCs in peripheral blood originate from solid tumors and are involved in the process of hematogenous metastatic spread to distant sites for the establishment of secondary foci of disease. The emergence of modern CTC technologies has enabled serial assessments to be undertaken at multiple time points along a patient's cancer journey for pharmacodynamic (PD), prognostic, predictive, and intermediate endpoint biomarker studies. Despite the promise of CTCs as multifunctional biomarkers, there are still numerous challenges that hinder their incorporation into standard clinical practice. This review discusses the key technical aspects of CTC technologies, including the importance of assay validation and clinical qualification, and compares existing and novel CTC enrichment platforms. This article discusses the utility of CTCs as a multifunctional biomarker and focuses on the potential of CTCs as PD endpoints either directly via the molecular characterization of specific markers or indirectly through CTC enumeration. We propose strategies for incorporating CTCs as PD biomarkers in translational clinical trials, such as the Pharmacological Audit Trail. We also discuss issues relating to intrapatient heterogeneity and the challenges associated with isolating CTCs undergoing epithelial–mesenchymal transition, as well as apoptotic and small CTCs. Finally, we envision the future promise of CTCs for the selection and monitoring of antitumor precision therapies, including applications in single CTC phenotypic and genomic profiling and CTC-derived xenografts, and discuss the promises and limitations of such approaches.See all articles in this CCR Focus section, “Progress in Pharmacodynamic Endpoints.”Clin Cancer Res; 20(10); 2553–68. ©2014 AACR.
Pharmacologic Biomarkers in the Development of Stratified Cancer Medicine
Authors: Figg William Douglas , Newell David R. 
Published: May 2014

Abstract
Clinical pharmacologic research plays a vital role in cancer drug development. In recent years, biomarker studies have become integral to this process, specifically the use of pharmacologic biomarkers in the development of targeted therapies and their translation to clinical practice. In this overview, we discuss the validation of pharmacodynamics (PD) biomarkers and highlight the circulating tumor DNA as a promising cancer biomarker to illustrate how PD biomarkers can be powerful tools for guiding treatment strategies. We provide insights into PD biomarker approaches for future development of novel therapies and their role in cancer medicine.
See all articles in this CCR Focus section, “Progress in Pharmacodynamic Endpoints.”
Clin Cancer Res; 20(10); 2525–9. ©2014 AACR.
Convergent and Divergent Cellular Responses by ErbB4 Isoforms in Mammary Epithelial Cells
Authors: Wali Vikram B. , Haskins Jonathan W. , Gilmore-Hebert Maureen , Platt James T. , Liu Zongzhi , Stern David F. 
Published: May 2014

Abstract
Associations of ErbB4 (ERBB4/HER4), the fourth member of the EGFR family, with cancer are variable, possibly as a result of structural diversity of this receptor. There are multiple structural isoforms of ERBB4 arising by alternative mRNA splicing, and a subset undergo proteolysis that releases membrane-anchored and soluble isoforms that associate with transcription factors and coregulators to modulate transcription. To compare the differential and common signaling activities of full-length (FL) and soluble intracellular isoforms of ERBB4, four JM-a isoforms (FL and soluble intracellular domain (ICD) CYT-1 and CYT-2) were expressed in isogenic MCF10A cells and their biologic activities were analyzed. Both FL and ICD CYT-2 promoted cell proliferation and invasion, and CYT-1 suppressed cell growth. Transcriptional profiling revealed several new and underexplored ERBB4-regulated transcripts, including: proteases/protease inhibitors (MMP3 and SERPINE2), the YAP/Hippo pathway (CTGF, CYR61, and SPARC), the mevalonate/cholesterol pathway (HMGCR, HMGCS1, LDLR, and DHCR7), and cytokines (IL8, CCL20, and CXCL1). Many of these transcripts were subsequently validated in a luminal breast cancer cell line that normally expresses ERBB4. Furthermore, ChIP-seq experiments identified ADAP1, APOE, SPARC, STMN1, and MXD1 as novel molecular targets of ERBB4. These findings clarify the diverse biologic activities of ERBB4 isoforms, and reveal new and divergent functions.
Implications: ErbB4 as a regulator of Hippo and mevalonate pathways provides new insight into milk production and anabolic processes in normal mammary epithelia and cancer. Mol Cancer Res; 12(8); 1140–55. ©2014 AACR.
A Monotonic and Prognostic Genomic Signature from Fibroblasts for Colorectal Cancer Initiation, Progression, and Metastasis
Authors: Berdiel-Acer Mireia , Cuadras Daniel , Díaz-Maroto Natalia Guillén , Sanjuan Xavier , Serrano Teresa , Berenguer Antoni , Moreno Victor , Gonçalves-Ribeiro Samuel , Salazar Ramon , Villanueva Alberto , Molleví David G. 
Published: May 2014

Abstract
The differential gene expression patterns between normal colonic fibroblasts (NCF), carcinoma-associated fibroblasts from primary tumors (CAF-PT), and CAFs from hepatic metastasis (CAF-LM) are hypothesized to be useful for predicting relapse in primary tumors. A transcriptomic profile of NCF (n = 9), CAF-PT (n = 14), and CAF-LM (n = 11) was derived. Prediction Analysis of Microarrays (PAM) was used to obtain molecular details for each fibroblast class, and differentially expressed transcripts were used to classify patients according to recurrence status. A number of transcripts (n = 277) were common to all three types of fibroblasts and whose expression level was sequentially deregulated according to the transition: NCF→CAF-PT→CAF-LM. Importantly, the gene signature was able to accurately classify patients with primary tumors according to their prognosis. This capacity was exploited to obtain a refined 19-gene classifier that predicted recurrence with high accuracy in two independent datasets of patients with colorectal cancer and correlates with fibroblast migratory potential. The prognostic power of this genomic signature is strong evidence of the link between the tumor-stroma microenvironment and cancer progression. Furthermore, the 19-gene classifier was able to identify low-risk patients very accurately, which is of particular importance for stage II patients, who would benefit from the omission of chemotherapy, especially T4N0 patients, who are clinically classified as being at high risk.
Implications: A defined stromal gene expression signature predicts relapse in patients with colorectal cancer. Mol Cancer Res; 12(9); 1254–66. ©2014 AACR.
Use of the GOES-R Split-Window Difference to Diagnose Deepening Low-Level Water Vapor
Authors: Lindsey Daniel T. , Grasso Louie , Dostalek John F. , Kerkmann Jochen 
Published: May 2014

AbstractThe depth of boundary layer water vapor plays a critical role in convective cloud formation in the warm season, but numerical models often struggle with accurate predictions of above-surface moisture. Satellite retrievals of water vapor have been developed, but they are limited by the use of a model’s first guess, instrument spectral resolution, horizontal footprint size, and vertical resolution. In 2016, Geostationary Operational Environmental Satellite-R (GOES-R), the first in a series of new-generation geostationary satellites, will be launched. Its Advanced Baseline Imager will provide unprecedented spectral, spatial, and temporal resolution. Among the bands are two centered at 10.35 and 12.3 μm. The brightness temperature difference between these bands is referred to as the split-window difference, and has been shown to provide information about atmospheric column water vapor. In this paper, the split-window difference is reexamined from the perspective of GOES-R and radiative transfer model simulations are used to better understand the factors controlling its value. It is shown that the simple split-window difference can provide useful information for forecasters about deepening low-level water vapor in a cloud-free environment.
Field Measurements of Rogue Water Waves
Authors: Christou Marios , Ewans Kevin 
Published: May 2014

AbstractThis paper concerns the collation, quality control, and analysis of single-point field measurements from fixed sensors mounted on offshore platforms. In total, the quality-controlled database contains 122 million individual waves, of which 3649 are rogue waves. Geographically, the majority of the field measurements were recorded in the North Sea, with supplementary data from the Gulf of Mexico, the South China Sea, and the North West shelf of Australia. The significant wave height ranged from 0.12 to 15.4 m, the peak period ranged from 1 to 24.7 s, the maximum crest height was 18.5 m, and the maximum recorded wave height was 25.5 m. This paper will describe the offshore installations, instrumentation, and the strict quality control procedure employed to ensure a reliable dataset. An examination of sea state parameters, environmental conditions, and local characteristics is performed to gain an insight into the behavior of rogue waves. Evidence is provided to demonstrate that rogue waves are not governed by sea state parameters. Rather, the results are consistent with rogue waves being merely extraordinary and rare events of the normal population caused by dispersive focusing.
Spectral Ocean Wave Climate Variability Based on Atmospheric Circulation Patterns
Authors: Espejo Antonio , Camus Paula , Losada Iñigo J. , Méndez Fernando J. 
Published: May 2014

Abstract
Traditional approaches for assessing wave climate variability have been broadly focused on aggregated or statistical parameters such as significant wave height, wave energy flux, or mean wave direction. These studies, although revealing the major general modes of wave climate variability and trends, do not take into consideration the complexity of the wind-wave fields. Because ocean waves are the response to both local and remote winds, analyzing the directional full spectra can shed light on atmospheric circulation not only over the immediate ocean region, but also over a broad basin scale. In this work, the authors use a pattern classification approach to explore wave climate variability in the frequency–direction domain. This approach identifies atmospheric circulation patterns of the sea level pressure from the 31-yr long Climate Forecast System Reanalysis (CFSR) and wave spectral patterns of two selected buoys in the North Atlantic, finding one-to-one relations between each synoptic pattern (circulation type) and each spectral wave energy distribution (spectral type). Even in the absence of long-wave records, this method allows for the reconstruction of long-term wave spectra to cover variability at several temporal scales: daily, monthly, seasonal, interannual, decadal, long-term trends, and future climate change projections.
Buddhist Scriptures: An Overview
Authors: Appleton Naomi 
Published: May 2014

In this article I provide an overview of what scripture means and does in a Buddhist context. The article has three main parts. First, by way of introduction I explore the history of Buddhist scripture and a few of the different ways in which scripture was defined and classified in the early period. In the second section I use the common division into three ‘baskets’ of scripture (discourses, monastic discipline and higher teachings) to structure a closer look at some of the main genres of early Buddhist texts. Finally I examine the role of scripture in Buddhist life, as a source of teachings, a means of making karmic merit, and a vehicle of great power. In the interests of time and space I have chosen to focus largely on the earliest scriptures of Indian Buddhism. Later compositions and compilations, such as the many scriptures of Tibetan or East Asian Buddhism, are not considered here.1 Because my focus is on the early Indian scriptures I use mainly Sanskrit (Skt) terminology, with the Pāli (P.) equivalent noted where relevant.
Reconsidering Social Movement Unionism in Postcrisis Argentina
Authors: Serdar Ayşe 
Published: May 2014

The Central de Trabajadores de la Argentina, established in 1992, worked to expand its base, especially among nonunion organizations, to construct an anti-neoliberal front. Driven by the threat of neoliberalism rather than by political opportunities, it was initially outstanding among social movement unions in its reach and its unity. It excelled not only in building alliances with the community but in organizing the community itself. However, the structural weakness resulting from its not being located in a key industrial sector and its lack of legal privileges, which was originally compensated for by its alliances, eventually made it unable to take advantage of changing political opportunities. La Central de Trabajadores de la Argentina, fundada en 1992, trabajó para ampliar su base, sobre todo entre las organizaciones no sindicales, para construir un frente anti-neoliberal. Impulsada por la amenaza del neoliberalismo más que por las oportunidades políticas, inicialmente se destacaba entre los sindicatos de los movimientos sociales en su alcance y su unidad. Se destacó no sólo en la construcción de alianzas con la comunidad, sino en la organización de la propia comunidad. Sin embargo, la debilidad structural que resulta de su no estar ubicado en un sector industrial clave y su falta de privilegios legales, lo que se compensó originalmente por sus alianzas, finalmente lo hizo incapaz de aprovechar de las cambiantes oportunidades políticas.
Arthrodesis After Failed Total Ankle Replacement
Authors: Deleu Paul-André , Devos Bevernage Bernhard , Maldague Pierre , Gombault Vincent , Leemrijse Thibaut 
Published: May 2014

Background: The literature on salvage procedures for failed total ankle replacement (TAR) is sparse. We report a series of 17 patients who had a failed TAR converted to a tibiotalar or a tibiotalocalcaneal arthrodesis. Methods: Between 2003 and 2012, a total of 17 patients with a failed TAR underwent an arthrodesis. All patients were followed on a regular basis through chart review, clinical examination and radiological evaluation. The following variables were analyzed: pre- and postoperative Meary angle, cause of failure, method of fixation, type of graft, time to union, complications, and postoperative American Orthopaedic Foot and Ankle Society (AOFAS) score. The average follow-up was 30.1 months. The average period from the original arthroplasty to the arthrodesis was 49.8 months. Results: Thirteen of the 17 ankles were considered radiographically healed after the first attempt in an average time of 3.7 months and 3 after repeat arthrodesis. Bone grafts were used in 16 patients. The median postoperative AOFAS score was 74.5. The mean Meary angle of the hindfoot was 5 degrees of valgus. Conclusion: Tibiotalar and tibiotalocalcaneal arthrodeses were effective salvage procedures for failed TAR. Massive cancellous allografts were a good alternative to compensate for the large bone defect after removal of the prosthesis and to preserve the leg length. Level of Evidence: Level IV, retrospective case series.
Effect of an IT-supported home-based exercise programme on metabolic syndrome in India
Authors: Radhakrishnan Jeyasundar , Swaminathan Narasimman , Pereira Natasha , Henderson Keiran , Brodie David 
Published: May 2014

Summary We studied the effectiveness of a home-based exercise programme with information technology (IT) support in people with metabolic syndrome in India. Ninety-four participants with metabolic syndrome (mean age 50 years) were randomized into two groups. Both groups received a 12-week home exercise programme and Group 2 received additional IT support for health education. Before and after the exercise programme, participants were measured for arterial stiffness using applanation tonometry, exercise capacity using an incremental shuttle walk test and quality of life (QoL) using the SF-36 questionnaire. Sixty-one participants completed the post intervention tests. There was a significant reduction in systolic blood pressure, mean pressure and aortic systolic pressure in both groups. Pulse wave velocity, aortic pulse pressure and aortic diastolic pressure showed significant reductions only in Group 2. There were no significant changes in QoL measures, except vitality in Group 2. There was significant improvement in fasting blood glucose in Group 2, cholesterol in Group 1 and triglycerides in both groups. The participants’ exercise capacity did not change significantly, although the mean duration of regular exercise was 7.2 weeks for Group 1 and 10.0 weeks for Group 2 ( P = 0.019). Metabolic syndrome was reversed in 16% of the participants in both groups. IT support, through mobile text messages and phone calls, may be helpful in metabolic syndrome. Longer-term studies are now required.
Trisomy 12 chronic lymphocytic leukemia cells exhibit upregulation of integrin signaling that is modulated by NOTCH1 mutations
Authors: Riches John C. , O’Donovan Conor J. , Kingdon Sarah J. , McClanahan Fabienne , Clear Andrew J. , Neuberg Donna S. , Werner Lillian , Croce Carlo M. , Ramsay Alan G. , Rassenti Laura Z. , Kipps Thomas J. , Gribben John G. 
Published: May 2014

Key PointsTrisomy 12 CLL cells exhibit upregulated integrin signaling and enhanced VLA-4-directed adhesion and motility. The increased expression of β2-integrins on trisomy 12 CLL cells is modulated by intercurrent NOTCH1 mutations.