bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of the treatment of Open Fracture of Tibia by Primary Nailing
Authors: Islam Mohammad Saiful , Karim Mohd Rezaul , Rahim Zamil Zaidur 
Published: July 2024

Aim: Open fracture of the tibia is most common in road traffic accident specially motor cycle accident. Topics of debate in the orthopaedic traumatology continue regarding the specific methods of bone stabilization and soft tissue management of open fracture of Tibia.
Objectives: To evaluate the results of intramedullary nailing in the open fractures of the tibia in Combined Military Hospital, Dhaka.
Material and Methods: A prospective study was done from January 2018 to June 2019in Combined Military Hospital, Dhaka. Total twenty cases were selected who sustained open fractures of tibia Gustilo and Anderson grades I, II and IIIA. Primary undreamed intramedullary interlocking nail fixation done after thorough debridement and wounds were closed with suture. All the patients were followed up for a minimum of one year.
Results: Of the total twenty cases, ten were of grade I, seven were of grade II and three were of grade IIIA injury. Dynamization was done in nine cases. The average time to union was 16.0 weeks in the grade I cases, 18.3 weeks in the grade II cases and 23.6 weeks in the grade III A cases. The mean time to union was 19.3 weeks. Infection occurred in 3 cases. Mal union was observed in one case of type IIIA. No case had any implant failure (nail / screw breakage), or deep vein thrombosis.
Conclusion: From our study we have concluded that the unreamed intramedullary nailing in cases of open fractures of the tibia with soft tissue closure results faster soft tissue and bony healing. Biomechanical stability, early rehabilitation and infection rates are also comparable to those which are seen with other methods.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 638-642
Evaluation of the foot health with baropodometric analysis of acromegaly patients followed after pituitary surgery
Authors: Karatoprak Ayfer Peker , Aydin Levent , Yüksel Burcu , Demirhan Yeliz , Baydemir Canan , Selek Alev , Cantürk Zeynep , çetinarslan Berrin 
Published: July 2024

Background: The exposure to growth hormone (GH) and increase in insulin-like growth factor 1 (IGF-1) in acromegaly can cause various clinical findings related to the cardiovascular, respiratory, and musculoskeletal systems. GH exerts its anabolic effects directly or indirectly through IGF-1, by increasing cell proliferation and maturation in various tissues, including bone, cartilage, skeletal muscle, and tendons. The aim of this study is to analyze these changes using baropodometric gait analysis.
Methods: Our study was conducted with a sample of 41 acromegaly patients and 42 control group individuals. Static, dynamic, and stabilometric baropodometric analyses were performed, as well as podoscanner analysis.
Results: According to the dynamic and static baropodometric analyses of both groups, the standing load distribution and stabilometric Romberg index findings were similar. However, the acromegaly group showed a higher prevalence of pes planus findings compared to the control group (p<0.003). Conversely, the control group showed a higher incidence of callus and corn formation (p=0.01).
Conclusions: Pes planus can disturb the load distribution in the foot, leading to the formation of pressure points. High pressure on the plantar surface of the foot is associated with the development of callus and corn. In this study, although pes planus was more common in the acromegaly group than in the control group, callus and corn formation in the forefoot region were higher in the control group (p=0.01). It was suggested that the soft tissue hypertrophy in acromegaly may be protective against callus and corn formation, which are expected to develop due to pressure. The podiatric approach can be used in other endocrinological diseases that affect the musculoskeletal system, such as acromegaly, especially in diabetic patients. Conducting baropodometric analysis and balancing load distribution with insoles can contribute to reducing the risk of fracture in acromegaly patients. Future studies with larger patient groups, including clinical and radiological findings, can be performed to further evaluate these results.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 698-705
The use of special exercises in the preparatory period of skiers
Authors: G G Polevoy 
Published: July 2024

Background: Recently, there has been a tendency to decrease the results of domestic skiers, in order to solve this problem, it is necessary to change the training approach in the preparatory period before the competition.
The purpose of the study: Improving the physical fitness of skiers using special training tools.
Materials and methods: In the Russian Federation, a pedagogical experiment was conducted in the village of Korshik. It was attended by teenagers aged 13-14 who were engaged in cross-country skiing. A total of 40 children participated (20-control and 20-experimental groups). The difference between the experimental group was the use of special exercises at the preparatory stage of training. The study used control standards that show the level of physical qualities, such as pull-ups, squats, long jumps, simulated 100m lifting and 500m running.
Results: The children from the experimental group significantly improved their performance in the pull-up test (22.2%; p<0.05), squats (5.9%; p<0.05), long jumps on two legs (6.8%; p<0.05), 100-simulated lifting per meter (7.8%; p<0.05) and running at 500 meters (4.2 %, p<0.05). At the same time, children from the control group were unable to show significant improvements in physical fitness (p>0.05).
Conclusión: During the preparatory period of ski racers, it is recommended to include special exercises that will significantly increase the level of physical qualities.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 818-825
Relationship between gingival recession and tooth brushing habits
Authors: Hashem Ahmed Shawkat , Patil Santosh R , Issrani Rakhi , Prabhu Namdeo , Albalawi Ahmed Saleh , Alam Mohammad Khursheed 
Published: July 2024

Background: Gingival recession is a common periodontal condition that can lead to aesthetic and functional problems. Tooth brushing habits have been suggested to be associated with gingival recession, but the evidence on this relationship is limited.
Aim: To investigate the relationship between gingival recession and tooth brushing habits in a sample of 100 patients.
Methodology: A cross-sectional study was conducted on 100 patients aged between 20 and 60 years who presented to a dental clinic. Demographic data, tooth brushing habits, and gingival recession depth were recorded. Descriptive statistics were used to summarize the data, and logistic regression analysis was performed to investigate the association between tooth brushing habits and gingival recession.
Results: The mean age of the participants was 40 years, and 52% of the participants were female. The mean gingival recession depth was 1.8 mm (SD=0.7). Majority of the participants brushed their teeth twice a day (65%), used manual tooth brushes (72%), used circular method for tooth brushing (54%), spent 2-3 minutes on tooth brushing (60%), and dental floss was the most commonly used additional oral hygiene aid (60%). The bivariate correlation analysis showed a statistically significant positive correlation between gingival recession and frequency of tooth brushing (r=0.28, p=0.01).
Conclusion: The findings of this study suggest that tooth brushing habits are significantly associated with the development and progression of gingival recession. Thus, oral health professionals should educate their patients about the proper tooth brushing techniques and the use of additional oral hygiene aids to prevent the development of gingival recession.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 846-850
A rare case of systemic mastocytosis with t(8;21) acute myeloid leukaemia in a young girl: a case report
Authors: Iberahim Salfarina , Mohd Noor Noor Haslina , Hassan Mohd Nazri , Zulkafl Zefarina , Abdullah Marne , Zulkeflee Razan Hayati , Ramli Marini , Bahar Rosnah , Yusoff Shafini Mohamed , Edinur Hisham Atan , Wan Ab Rahman Wan Suriana 
Published: July 2024

Mastocytosis is a rare disorder due to the abnormal proliferation of clonal mast cells. Mast cells exist in most tissues, mature in situ from hematopoietic stem cells and develop unique characteristics of local effector cells. It manifests as two main categories: cutaneous mastocytosis and systemic mastocytosis (SM). Patients presenting with SM–acute myeloid leukaemia (AML) often have the worst outcome. Here we present a patient with the simultaneous diagnosis of SM associated with t (8;21) (q22;q22) acute myeloid leukaemia, M2 subtype in the French-American-British (FAB) classification, carrying a population of immature mast cell precursors. Initially, she was diagnosed with AML with t (8;21) (q22;q22) and was started on induction chemotherapy. Subsequent trephine biopsy evaluation post-induction chemotherapy showed no increase in blast cells. However, abnormal mast cells were seen distributed throughout the marrow spaces, which expressed mast cell tryptase, CD117 and CD68. She was then diagnosed as SM associated with t(8;21) (q22;q22) AML. Unfortunately, she succumbed to death due to severe neutropenic sepsis post- induction chemotherapy. By sharing the knowledge, hopefully it will help the clinicians as the diagnosis of SM is difficult to establish because the associated malignancy may obscure the morphological features of SM. However, a reduction in blast cell percentage at the time of a post-induction marrow evaluation helps in diagnosis.
Bangladesh Journal of Medical Science Vol. 23 No. 03 July’24 Page : 873-876
Painel epidemiológico de pacientes gestantes submetidas a apendicectomia em centro de referência na Amazônia no período de janeiro de 2015 a outubro de 2021
Authors: Ferreira Bruno Pinheiro , Moreira Matheus Acácio 
Published: July 2024

Objetivo: Descrever um painel epidemiológico de grávidas abordadas cirurgicamente devido quadro de apendicite aguda em hospital de referência na Amazônia entre janeiro de 2015 e outubro de 2021. Metodologia: Realizou-se um estudo observacional, retrospectivo e descritivo, através de dados em prontuários de pacientes gestantes submetidos a apendicectomias na FSCMPA no período proposto. Análise dos dados: Foi realizada através do programa BioEstat 5.0, foi utilizado o teste G para comparação das categorias e o valor de significância para análise foi o menor que 5% (alfa de 5%). Resultado: Um estudo com 30 gestantes submetidas a apendicectomia em Belém-Pará entre março de 2015 e outubro de 2021 revelou que a maioria tinha entre 21 a 30 anos e estava no 2º trimestre de gestação. Cerca de 46,7% tiveram diagnóstico histológico positivo para apendicite, com ultrassonografia sendo o exame mais solicitado (56,7%). O tempo médio de permanência foi de 10 dias, sem associação significativa com exames ou diagnóstico histológico, mas houve relação com a idade gestacional. A solicitação de exames de imagem esteve associada à presença de febre. Considerações finais: O estudo analisou apendicite em gestantes na Amazônia, com resultados similares a outros estudos. Destacou complicações no terceiro trimestre, correlação entre febre e exames de imagem e baixa taxa de diagnósticos errados. Além disso, apontou problemas em prontuários de hospitais locais.
Interferência da pobreza na gestão da higiene menstrual: Um protocolo de scoping review
Authors: Marques Ranah Agra , Sousa Mayara da Silva , Gonçalves Roberta Lima 
Published: July 2024

Este artigo visa apresentar o protocolo de scoping review para mapear na literatura evidências existentes e identificar lacunas sobre a interferência da pobreza na gestão da higiene menstrual. A metodologia adotada, seguirá o método do Joanna Briggs Institute (JBI) e as diretrizes do PRISMA Extension Scoping Reviews (PRISMA ScR). A revisão de escopo será construída em cinco etapas: 1) Identificação da questão de pesquisa; 2) Identificação dos estudos relevantes; 3) Seleção dos estudos; 4) Extração dos dados; e, 5) Sumarização, análise e apresentação dos dados. A busca será realizada na Cumulative Index to Nursing and Allied Health Literature (CINAHL), na Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Medical Literature Analysis and Retrievel System Online (MEDLINE). Os artigos selecionados, serão importados para os softwares Endnote e o Rayyan, a fim de auxiliar na organização e análise. Este protocolo está registrado no Open Science Framework garantindo visibilidade do processo de revisão.
Enfermagem no manejo da dor oncológica: Revisão integrativa de literatura
Authors: Santos Amanda Araújo dos , Alves Fernanda Cristina Rosa , Moreira Neila Maria Ewerton , Barros Micheli Mayara Souza , Moura Aline Carvalho , Cruz Milena Costa de Souza da , Antunes Heloana Monteiro 
Published: July 2024

Objetivo: Analisar e reunir informações para a compreensão do papel da enfermagem na avaliação e manejo da dor oncológica a fim de evidenciar a importância dos cuidados de enfermagem para a promoção da qualidade de vida do paciente oncológico. Metodologia: Trata-se de um estudo descritivo, qualitativo, do tipo Revisão Integrativa de Literatura, e foram utilizadas as bases de dados Medical Literature Analysis and Retrievel System Online (MEDLINE) e Literatura Latino-Americana e do Caribe em Ciências em Saúde (LILACS) através da Biblioteca Virtual de Saúde (BVS). Com relação aos Descritores em Ciência da Saúde (DECS/MESH) foram utilizados: Cuidados de Enfermagem; Enfermagem; Manejo da Dor e Dor do Câncer, nos idiomas português, inglês e espanhol. Resultados e Discussão: Foram incluídos 6 artigos para compor o escopo desta revisão. Durante o estudo foi possível constatar que existe um déficit de conhecimento dos enfermeiros em relação ao uso de opióides para controle da dor do paciente oncológico. Do mesmo modo, segundo os estudos analisados eles possuem conhecimento inadequado do tema, por tanto urge a necessidade de aperfeiçoamento constante. Considerações Finais: De acordo com os estudos analisados, conclui-se que a dor em pacientes com câncer deve ser tratada com a mesma importância que outros sintomas considerados graves. Para tal, é importante que o enfermeiro empodere-se de conhecimento para manejar de forma adequada a dor, com uso de escalas para sua avaliação, e saiba o momento e a forma adequada de intervir em cada caso.
Self-regulated learning and engagement through emergency remote teaching in EFL undergraduate students
Authors: Oportus-Torres René , Contreras-Soto Yasmina , Sanhueza-Campos Cristian , Maluenda-Albornoz Jorge , Pérez-Villalobos Christian , Quintanilla-Espinoza Angie 
Published: July 2024

IntroductionAn important concern of research about self-regulated learning is to determine the most effective methods for its instruction in different educational settings. This also happens in foreign language learning as improving proficiency is challenging for students and self-regulation has proven effective in different educational levels.MethodsA quasi-experimental study was designed with a treatment and a control group, and pre- and post-test for 70 undergraduate students majoring in English as a foreign language at a Chilean university. A 10-week intervention was conducted to develop self-regulation during emergency remote teaching.ResultsFindings revealed that the intervention, as implemented in the study, was successful in improving self-regulated learning, and in participants’ recognizing the practical utility of tools acquired. On the other hand, while the level of engagement remained similar after the intervention, this was seen as a protective effect of the teaching-learning strategy on motivational states.DiscussionThis research underscores the importance of self-regulated learning training in higher education to allow for students’ autonomy and agency, as well as connectedness with instructors and peers, especially during the harsh teaching conditions of sanitary confinement.
Exploring gut microbiota and metabolite alterations in patients with thyroid-associated ophthalmopathy using high-throughput sequencing and untargeted metabolomics
Authors: Zhang Xiran , Dong Kui , Zhang Xinxin , Kang Zhiming , Sun Bin 
Published: July 2024

IntroductionThyroid-associated ophthalmopathy (TAO) is an autoimmune-driven orbital inflammatory disease. Despite research efforts, its exact pathogenesis remains unclear. This study aimed to characterize the intestinal flora and metabolic changes in patients with TAO to identify the flora and metabolites associated with disease development.MethodsThirty patients with TAO and 29 healthy controls were included in the study. The intestinal flora and metabolites were analyzed using high-throughput sequencing of the 16S rRNA gene and non-targeted metabolomics technology, respectively. Fresh fecal samples were collected from both populations for analysis.ResultsReduced gut richness and diversity were observed in patients with TAO. Compared to healthy controls, significant differences in relative abundance were observed in patients with TAO at the order level Clostridiales, family level Staphylococcaceae, genus level Staphylococcus, Fournierella, Eubacterium siraeum, CAG-56, Ruminococcus gnavus, Intestinibacter, Actinomyces, and Erysipelotrichaceae UCG-003 (logFC&gt;1 and P&lt;0.05). Veillonella and Megamonas were closely associated with clinical symptoms in patients with TAO. Among the 184 significantly different metabolites, 63 were upregulated, and 121 were downregulated in patients with TAO compared to healthy controls. The biosynthesis of unsaturated fatty acids was the significantly enriched metabolic pathway. Correlation analysis revealed Actinomyces was positively correlated with NAGlySer 15:0/16:0, FAHFA 3:0/20:0, and Lignoceric Acid, while Ruminococcus gnavu was positively correlated with Cer 18:0;2O/16:0; (3OH) and ST 24:1;O4/18:2.ConclusionSpecific intestinal flora and metabolites are closely associated with TAO development. Further investigation into the functional associations between these flora and metabolites will enhance our understanding of TAO pathogenesis.
Waist circumference glucose, a novel and effective predictor of type 2 diabetes: a prospective cohort study
Authors: Zhao Xiaofang , Song Bei , Yao Tianci , Fan Haohui , Liu Ting , Gao Guangyu , Wang Kun , Lu Weilin , Liu Chengyun 
Published: July 2024

IntroductionWaist circumference (WC) and fasting plasma glucose (FPG) have been demonstrated as risk factors for type 2 diabetes mellitus (T2DM). Evidence is limited regarding the association of the combination of WC and FPG (WyG) with the risk of T2DM. The primary aim of the study was to investigate the relationship between WyG and T2DM.Research design and methodsThe current study was a population-based cohort study using data from the NAGALA database. Participants were divided into tertiles based on WyG. Cox proportional hazard regression model was applied to identify the association of WyG with T2DM.ResultsDuring a median follow-up of 6.19 years in the normoglycemia group and 5.58 years in the prediabetes group, respectively, 88 and 285 individuals in the two groups received a diagnosis of T2DM. After full adjustment, risk of T2DM increased in step-wise fashion with increasing tertiles of WyG. For a per-SD increase in WyG, the hazard ratios for T2DM were 3.05 (95% CI 2.64 - 3.51) in all populations, 1.94 (95% CI 1.46 - 2.58) in the normoglycemia group and 1.63 (95% CI 1.40 - 1.90) in the prediabetes group. The interaction between WyG and fatty liver on T2DM was statistically significant in the prediabetes group (P for interaction = 0.034).ConclusionsElevated WyG was independently associated with incident T2DM in Japan. Baseline WyG help identify individuals at high risk of T2DM and implement effective preventive measures.
The prevalence, diagnostic accuracy and genotype-phenotype correlation of GNAS mutations in fibrous dysplasia: a meta-analysis
Authors: Zhang Ao-Bo , Zhang Jian-Yun , Xue Jiang , Wu Zhen-Chao , Xu Zhi-Xiu , Sun Li-Sha , Li Tie-Jun 
Published: July 2024

BackgroundThere is inconsistent evidence regarding the accuracy of GNAS mutations identification for the diagnosis of FD/MAS. This study was performed to estimate the prevalence and diagnostic accuracy of GNAS mutations detection and to preliminarily investigate the genotype-phenotype correlation in FD patients.MethodsFive electronic databases were searched from 1995 to 2024 using search terms related to GNAS and fibrous dysplasia. Observational studies of FD patients undergoing GNAS mutation detection in FD were included.ResultsA total of 878 FD patients were included. The pooled prevalence of GNAS mutations in FD based on the random effects model was 74% (95% CI = 64%–83%). Regarding diagnostic accuracy, a sensitivity of 0.83 (95% CI, 0.65–0.96), specificity of 0.99 (95% CI, 0.98–1.00) and the area under the receiver operating characteristic curve of 98.38% were found. Additionally, meta-analysis and Fisher’s test showed the GNAS mutation types were significantly associated with FD types (OR = 3.51, 95% CI = 1.05 to 11.72; p &lt; 0.05).ConclusionA high detection rate of GNAS mutations occurred in FD, and its detection is reliable for diagnosing FD. Additionally, GNAS mutation type was types were significantly associated with FD type.Systematic Review Registration Identifier CRD42024553469.
Discovery of oxazine-linked pyrimidine as an inhibitor of breast cancer growth and metastasis by abrogating NF-κB activation
Authors: Yuan Jie , Narasimhachar Bhanuprakash C. , Ravish Akshay , Yang Li , Zhang Hua , Wang Qun , Li Zhi , Huang Jun , Wang Bei , Wang Geng , Kumar Harish Keshav , Chinnathambi Arunachalam , Govindasamy Chandramohan , Madegowda Mahendra , Basappa Basappa 
Published: July 2024

IntroductionNuclear factor kappa (NF-κB) plays a key role in cancer cell proliferation; thus, small molecule inhibitors of NF-κB activity can effectively inhibit breast cancer (BC) progression. We have previously reported oxazine and piperazine-linked pyrimidines as novel anti-cancer agents that can suppress NF-κB activation in BC cells. Moreover, the TRX-01 compound, an oxazine-linked pyrimidine, inhibited MCF-7 cells at a concentration of 9.17 µM in the Alamar Blue assay.MethodsThis work involved the analysis of frontier molecular orbitals, HOMO-LUMO interactions, and molecular electrostatic potential for the TRX-01 structure. Additionally, the TRX-01 compound was studied for cytotoxicity, and migration as well as invasion assays were performed on BC cells.ResultsFinally, TRX-01 blocked the translocation of NF-κB from the cytoplasm to the nucleus in MCF-7 cells and reduced NF-κB and IκBα levels in a dose-dependent manner. It also suppressed migratory and invasive properties of BC cells.ConclusionOverall, the data indicates that TRX-01 can function as a novel blocker of BC growth and metastasis by targeting NF-κB activation.