bluuebunny/crossref_metadata_2025_split huggingface dataset:
Genetic Landscape of Amyotrophic Lateral Sclerosis in Czech Patients
Authors: Baumgartner Daniel , Mušová Zuzana , Zídková Jana , Hedvičáková Petra , Vlčková Eva , Joppeková Lubica , Kramářová Tereza , Fajkusová Lenka , Stránecký Viktor , Geryk Jan , Votýpka Pavel , Mazanec Radim 
Published: July 2024

Background: Genetic factors are involved in the pathogenesis of familial and sporadic amyotrophic lateral sclerosis (ALS) and constitute a link to its association with frontotemporal dementia (FTD). Gene-targeted therapies for some forms of ALS (C9orf72, SOD1) have recently gained momentum. Genetic architecture in Czech ALS patients has not been comprehensively assessed so far. Objective: We aimed to deliver pilot data on the genetic landscape of ALS in our country. Methods: A cohort of patients with ALS ( n = 88), recruited from two Czech Neuromuscular Centers, was assessed for hexanucleotide repeat expansion (HRE) in C9orf72 and also for genetic variations in other 36 ALS-linked genes via next-generation sequencing (NGS). Nine patients (10.1%) had a familial ALS. Further, we analyzed two subgroups of sporadic patients – with concomitant FTD ( n = 7) and with young-onset of the disease ( n = 22). Results: We detected the pathogenic HRE in C9orf72 in 12 patients (13.5%) and three other pathogenic variants in FUS, TARDBP and TBK1, each in one patient. Additional 7 novel and 9 rare known variants with uncertain causal significance have been detected in 15 patients. Three sporadic patients with FTD (42.9%) were harbouring a pathogenic variant (all HRE in C9orf72). Surprisingly, none of the young-onset sporadic patients harboured a pathogenic variant and we detected no pathogenic SOD1 variant in our cohort. Conclusion: Our findings resemble those from other European populations, with the highest prevalence of HRE in the C9orf72 gene. Further, our findings suggest a possibility of a missing genetic variability among young-onset patients.
Analisis Ergonomi untuk Mengurangi Keluhan MSDs pada Kegiatan Penyadapan Karet
Authors: TEKMAPRO Raizummi Fil'aini , TEKMAPRO Joyce Rebeka Gultom , TEKMAPRO Zunanik Mufidah , TEKMAPRO Tri Novita Sari , TEKMAPRO Harmiansyah 
Published: July 2024

Permasalahan utama yang masih terjadi di Indonesia adalah rata-rata tingkat produktivitas karet masih lebih rendah dibandingkan dengan negara pesaingnya yaitu Thailand. Ketika melakukan penyadapan, terdapat berbagai posisi kerja tidak ergonomis yang dapat menyebabkan petani menjadi lebih cepat lelah, sulit berkonsentrasi dan lambat dalam bekerja sehingga berakibat pada penurunan produktivitas. Dalam melakukan aktivitasnya, petani akan berdiri dalam waktu yang lama, berjongkok, memutar tubuh, berjinjit, dan membungkuk menyesuaikan dengan tinggi sadapan. Postur tubuh tidak ergonomis tersebut dapat memicu terjadinya keluhan Musculoskeletal Disorders (MSDs) yaitu masalah pada sistem skletal tubuh manusia. Oleh karena itu, perlu dilakukan identifikasi melalui pendekatan ergonomi berupa analisis postur kerja. Penelitian ini bertujuan untuk menganalisis tingkat risiko ergonomi postur kerja dan tingkat keparahan keluhan Musculoskeletal Disorder (MSDs) pada petani penyadap karet. Metode analisis postur yang digunakan adalah Rapid Entire Body Assessment (REBA), dikombinasikan dengan metode Nordic Body Map (NBM) untuk mengetahui tingkat risiko Musculoskeletal Disorders (MSDs) pada petani. Hasil penelitian menunjukkan bahwa tingkat risiko ergonomi postur kerja petani berada pada level 4 dengan skor REBA 12 artinya memiliki risiko yang sangat tinggi. Tingkat keparahan keluhan Musculoskeletal Disorder (MSDs) yang dirasakan oleh petani yaitu sangat sakit sebesar 77% pada leher bawah dan pinggang, 66% pada leher atas, serta 55% pada punggung dan betis.
Implementasi Ta’zir Dalam Peningkatan Kesadaran Diri Santri (Studi Kasus Di Pondok Pesantren Putri Walisongo Cukir Jombang)
Authors: Wan Nurlaila Putri  , Aida Arini  
Published: July 2024

Adanya sebuah hukuman (ta’zir) di pondok pesantren memang dinilai bisa mampu memberikan rasa jera kepada santri hingga para santri tidak dengan sengaja untuk melanggar aturan yang telah ada di pondok, tujuan dari ta’zir adalah untuk mencegah timbulnya perilaku buruk dan untuk menanamkan sikap disiplin pada santri. Agar ta’zir bisa menjadi efektif, ta’zir (hukuman) seharusnya kekuatan yang besar dan tegas akan tetapi tetap tidak membuat santri merasa menderita dan tersiksa. Persoalan yang dibahas dalam artikel ini adalah a) bagaimana bentu-bentuk ta’zir di PPP Walisongo Cukir Jombang b) bagaimana implementasi ta’zir dalam meningkatkan kesadaran diri santri c) bagaimana bentuk kesadaran diri santri. Adapun jenis penelitian yang peneliti pakai adalah kualitatif, pada metode pendekatan studi kasus. Informan dari penelitian ini terdiri dari, pembimbing lembaga madrasah hifdzil qur’an, ketua mabna lembaga madrasah hifdzil qur’an, pengurus bidang Kamanan madrasah hifdzil qur’an, dan dua santri madrasah hifdzil qur’an. Berdasarkan hasil penelitian didapatkan bahwa di PPP Walisongo Cukir Jombang khususnya lembaga madrasah hifdzil qur’an(mhq) a). bentuk-bentuk ta’zirannya ada yang ringan, sedang, dan berat b). impelementasi ta’zirannya melalui beberapa tahap seperti peneguran, pencatatan, pemanggilan, pelaksaanan ta’zir. Dilakukan secara perorangan dan berkelompok.dan tentunya memiliki beberapa kendala seperti tempat, waktu, dan santri itu sendiri c). bentuk kesadaran diri santri adalah mandiri dalam beribadah dan dalam peraturan, bertanggung jawab serta intropeksi diri.
Praktik Hutang Piutang Dalam Jual Beli Kebutuhan Pokok Di Warung Pojok Bu Umi Jombang Perspektif Hukum Bisnis Syariah
Authors: Hikmah Usulul hikmah , Norma Fitria  
Published: July 2024

Dalam kehidupan manusia sejatinya tidak pernah lepas dari kegiatan bermuamalah untuk memenuhi kebutuhan hidupnya. Muamalah merupakan pergaulan hidup setiap orang yang melakukan perbuatan sosisal dengan orang lain yang nantinya akan menimbulkan suatu hak dan kewajiban. Hutang piutang ini merupakan tindakan terpuji karena terdapat sifat tolong-menolong antar sesama yang saling membutuhkan, karena kita hidup di anjurkan untuk saling membantu penelitian yang digunakan dalam penelitian ini adalah yuridis empiris, sedangkan teknik pengumpulan data yang digunakan adalah observasi, wawancara dan dokumentasi. Teknik analisis data yang digunakan adalah analisa induktif. Dari hasil penelitian dapat disimpulkan bahwa (1) Memenuhi kebutuhan sehari-hari memang sangat bermanfaat adanya warung pojok Bu Umi yang memberikan hutang kepada pelanggannya tetapi penjual tetap mencatat dalam pembukuannya agar dapat dingatkan untuk membayar hutang, tetapi pembeli atau yang memiliki hutang tidak terlalu lama dalam membayar hutang ke warung pojok Bu Umi. (2) Jika mengacu pada perspektif Hukum Bisnis Syariah tentunya sudah termasuk di dalamnya karena sudah melakukan secara akad yang sama kedua belah pihak tidak merasa terpaksa, dan penjual juga mencatat apa yang di ambil oleh pembeli, adapun akad yang di lakukan oleh keduanya secara lisan yang mana hal ini tentu sering dilakukan oleh setiap pelanggan yang berhutang di warung pojok Bu Umi.
Soil sorption and effects on soil microorganisms of thymol and carvacrol monoterpenes from essential oils of aromatic plants
Authors: Thiele-Bruhn Sören , Shikuku Victor , Dittrich Felix , Torjir Doosuur Naomi , Saini Mitali , Getenga Zachary 
Published: July 2024

To increase the biodiversity of agricultural systems, aromatic plants appear particularly promising as additional perennial crops in intercropping. They produce essential oils that contain monoterpenes, for example. These compounds have antibiotic properties that make them interesting for commercialisation as medicinal or pesticide products, but also carry the risk of undesirable effects on soil microorganisms and thus on essential soil functions. To investigate this, the monoterpenes thymol and carvacrol and a set of four typical agricultural soils were selected and soil sorption batch tests and soil toxicity tests were carried out to determine dose-response relationships. Sorption followed second order kinetics and was best described at equilibrium by the non-linear BET isotherm that distinguishes between monolayer and multilayer sorption of the non-polar compounds. While the kinetics were very fast with rate constants of 1.66 × 10−4 and 0.70 × 10−4 min−1 for thymol and carvacrol, the strength of sorption remained quite low (Kd 1.93–3.69), indicating a high mobility and bioavailability of the monoterpenes. In addition, the relation to single soil properties remained low, indicating a multivariate impact of several soil properties. Although thymol and carvacrol are isomeric compounds, they differed in the rate and strength of sorption as well as in the effects on five selected soil microbiological enzyme activities. In particular, carvacrol caused inhibition of enzyme activities, whereas thymol did not produce measurable or relevant effects in all cases. The effect concentrations of 10% and 25% percent inhibition (EC10, EC25) ranged from &lt;1 µg to several grams per Gram of soil and hormesis effects were also observed at low concentrations. On the one hand, this indicates only low toxicity; on the other hand, several of the defined effect thresholds can be reached or exceeded by expected environmental concentrations. This may harbour a risk of adverse effects, but may also have a phytosanitary effect, which requires further research.
Chronic hepatitis E virus-induced spinal cord atrophy in a patient with chronic lymphatic leukemia: a case report and interdisciplinary management proposal
Authors: Ritter Marvin , Yomade Olaposi , Holtz Ben-Ole , Deinhardt-Emmer Stefanie , McLean Aaron Lawson , Hartinger Stefanie , Bechwar Julia , Schwab Matthias , Huss André , Mawrin Christian , Axer Hubertus , Schrenk Karin G. , Reuken Philipp A. , Mäurer Irina 
Published: July 2024

BackgroundThe hepatitis E virus (HEV) can cause acute viral hepatitis with or without neurological manifestations, and occasionally progresses to chronic infection in immunocompromised individuals. The management of chronic HEV infection in cancer patients may be challenging due to the complex immunological constellation. Furthermore, the diagnostic workflow and the impact on quality of life of neurological HEV manifestations in immunocompromised patients have not been sufficiently delineated previously.Case descriptionA 61-year-old male with systemically treated chronic lymphocytic leukemia (CLL) experienced a slowly progressive atrophy of the spinal cord due to a chronic HEV infection. Despite continuous antiviral treatment with ribavirin, the patient’s neurological condition continued to deteriorate, particularly following subsequent attempts to treat CLL. Treatment with obinutuzumab resulted in acute bowel and urinary retention and a further deterioration of motor skills, prompting the discontinuation of obinutuzumab. The patient’s neurological status improved after the administration of intravenous immunoglobulins.ConclusionThis case study provides a comprehensive long-term follow-up of a cancer patient with chronic HEV infection and associated CNS involvement, which resulted in progressive neurological disability over several years. The challenges faced in diagnosing new neurological symptoms in patients undergoing immunosuppressive cancer treatment underscore the need for an interdisciplinary diagnostic approach that includes HEV testing. We propose a diagnostic pathway for future validation in immunocompromised cohorts presenting with neurological symptoms, emphasizing its potential to enhance clinical outcomes.
Efficacy assessment of liposome crosslinked hyaluronic acid and standard hyaluronic acid eye drops for dry eye disease management: a comparative study employing the ocular surface analyzer and subjective questionnaires
Authors: Sánchez-González José-María , De-Hita-Cantalejo Concepción , González-Rodríguez María Luisa , Fernández-Trueba-Fagúndez Ana , Ballesteros-Sánchez Antonio , Martinez-Perez Clara , Caro-Díaz Romina , Guzman Carla Montiel , González-Oyarce María Fernanda , Sánchez-González María Carmen 
Published: July 2024

IntroductionDry eye disease (DED) is a prevalent condition causing ocular discomfort and visual disturbances, often managed with artificial tears. This study aimed to assess and compare the efficacy of eye drops containing Crosslinked Hyaluronic Acid (CHA) with liposomes and crocin and standard Hyaluronic Acid (HA) for DED management.MethodsA single-blind, longitudinal study was conducted on 24 participants (48 eyes), randomized to receive one of the two treatments. Ocular health measures, including the ocular surface disease index (OSDI) and the standard patient evaluation of eye dryness (SPEED) scores, were assessed at baseline and 6 weeks post-treatment using the Ocular Surface Analyzer.ResultsCHA achieved a lipid layer thickness increase of 1.29 ± 1.08 Guillon pattern degree (p &lt; 0.01), FNIBUT increase 0.64 ± 0.77 s (p &lt; 0.01), MNIBUT increase1.28 ± 4.74 s (p = 0.19), OSDI decrease 11.72 ± 6.73 score points (p &lt; 0.01) and SPEED decrease 1.16 ± 5.05 score points (p = 0.27). Significant reductions in the OSDI and SPEED scores post-treatment were observed with both treatments, indicating their effectiveness.ConclusionCHA with liposomes exhibits superior efficacy compared to standard HA eye drops in the management of DED. These findings highlight the potential for personalized treatment strategies incorporating CHA, indicating a more effective approach to DED management. However, further research is required to validate these results and investigate the long-term effects, which may pave the way for a data-driven and optimized approach to managing DED.
Dazomet fumigation modification of the soil microorganism community and promotion of Panax notoginseng growth
Authors: Lin Ya-meng , Li Ming-hua , Dai Chun-yan , Liu Yuan , Zhang Wen-ping , Yang Qian , Cui Xiu-ming , Yang Ye 
Published: July 2024

IntroductionPanax notoginseng, a medicinal herb in China, is attacked by several pathogens during its cultivation. Dazomet (DZ) is a soil fumigant that is effective in controlling soil-borne pathogens, but its long-term effects on P. notoginseng growth and soil properties are unknown.MethodsWe conducted field experiments over two consecutive years to assess the impact of three concentrations of DZ fumigation (35 kg/666.7 m2, 40 kg/666.7 m2, and 45 kg/666.7 m2) on soil physicochemical properties, microbial diversity, and P. notoginseng growth. Correlation analyses were performed between microbial community changes and soil properties, and functional predictions for soil microorganisms were conducted.ResultsDZ fumigation increased total nitrogen, total phosphorus, total potassium, available phosphorus, available potassium, and ammonia nitrogen levels in the soil. DZ fumigation promoted the nutrient accumulation and improvement of agronomic traits of P. notoginseng, resulted in a 2.83–3.81X yield increase, with the highest total saponin content increasing by 24.06%. And the 40 kg/666.7 m2 treatment had the most favorable impact on P. notoginseng growth and saponin accumulation. After DZ fumigation, there was a decrease in the relative abundance of pathogenic fungi such as Fusarium, Plectosphaerella, and Ilyonectria, while beneficial bacteria such as Ramlibacter, Burkholderia, and Rhodanobacteria increased. The effects of fumigation on soil microorganisms and soil physicochemical properties persisted for 18 months post-fumigation. DZ fumigation enhanced the relative abundance of bacteria involved in the biosynthesis of secondary metabolites and arbuscular mycorrhizal fungi, reduced the relative abundance of plant–animal pathogenic fungi, reduced the occurrence of soil-borne diseases.ConclusionIn conclusion, DZ fumigation enhanced soil physicochemical properties, increased the proportion of beneficial bacteria in the soil, and rebalanced soil microorganism populations, consequently improving the growth environment of P. notoginseng and enhancing its growth, yield, and quality. This study offers a theoretical foundation for DZ fumigation as a potential solution to the continuous cropping issue in perennial medicinal plants such as P. notoginseng.
Muscular toxicity of colchicine combined with statins: a real-world study based on the FDA adverse event reporting system database from 2004–2023
Authors: Liu Ying , Wei Chunyan , Yuan Yanling , Zou Dan , Wu Bin 
Published: July 2024

BackgroundThrough an analysis of the Food and Drug Administration Adverse Event Reporting System (FAERS), we explored the signal strength of adverse reactions (ADRs) related to myopathy caused by the combination of colchicine and statins and gained insight into the characteristics of these myopathy related ADRs.MethodsWe extracted data from the FAERS database about ADRs in individuals with myopathy resulting from the combination of colchicine and statins. The analysis was conducted for the period spanning from January 2004 to December 2023 using the reported odds ratio (ROR) and information component (IC) methods to assess muscle-related ADR signals.ResultsA total of 18,386 reports of statin myopathy-associated adverse reactions, 348 colchicine myopathy-associated adverse reactions, and 461 muscle-associated adverse reactions due to the combination of the two were collected; the strongest signals of statin myotoxicity events were for necrotizing myositis (ROR 50.47, 95% CL 41.74–61.01; IC 3.70 95% CL 3.25–4.08); the strongest signal for colchicine myotoxicity events was toxic myopathy (ROR 32.50, 95% CL 19.74–53.51; IC 4.97 95% CL 1.89–5.10), and the strongest signal for statins combined with colchicine was toxic myopathy (ROR 159.85, 95% CL 111.60–228.98; IC 7.22 95% CL 3.59–5.9); muscle-related adverse reactions signals were meaningful when the two drugs were combined in the order of colchicine combined with fluvastatin (ROR 187.38, 95% CL 96.68–363.17; IC 6.99 95% CL 1.65–5.68); colchicine combined with simvastatin in 135 cases (ROR 30.08. 95% CL 25.25–35.85; IC 4.80 95% CL 3.96–5.12); and colchicine combined with rosuvastatin (ROR 25.73, 95% CL 20.16–32.83; IC 4.59 95% CL 3.38–4.98) versus colchicine combined with atorvastatin (ROR 25.73, 95% CL 22.33–29.66; IC 4.59 95% CL 3.97–4.91) with almost identical signal intensity, followed by colchicine combined with pravastatin (ROR 13.67, 95% CL 9.17–20.37; IC 3.73 95% CL 1.87–4.47), whereas no signals were generated for lovastatin or pitavastatin.ConclusionSimilar ADRs can occur when colchicine and statins are used individually or in combination; however, the strength of these reactions may differ. To minimize the risk of drug interactions, statins with less potential interactions, such as lovastatin, pitavastatin, and pravastatin, should be chosen, and myopathy-related indices and symptoms should be closely monitored during use.
The methodology of resistance training is crucial for improving short-medium distance front crawl performance in competitive swimmers: a systematic review and meta-analysis
Authors: Jin Guoli , Jin Yangqin , Zhang Haoyang , Fu Xueying , Yang Yong , Lin Shu-Cheng 
Published: July 2024

BackgroundResistance training is often a part of the routine training regimen for competitive swimmers. However, due to the variety of resistance training methodology, the results can be inconsistent and sometimes unsatisfactory. Clear recommendations are still lacking at present.Aims1) Quantify the impact of resistance training on swimmers’ upper limb maximum strength, front crawl performance and key technical parameters; 2) Find out the key technical parameters for improving front crawl performance—stroke rate or length; 3) Through subgroup analysis determine the best methodology of resistance training to enhance the front crawl.MethodsSystematic search in the PubMed, Embase, and Web of Science databases. Meta-analyses using the inverse-variance are performed to compare swimmers’ upper limb maximum strength, front crawl performance and key technical parameters in resistance training and habitual aquatic training. A subgroup analysis was performed to examine whether the results were affected by the methodology of resistance training.ResultsThirteen studies (267 competitive swimmers) met the inclusion criteria. The results of meta-analysis showed that resistance training significantly improved upper limbs maximum muscle strength, and 25, 50, 100, and 200 m front crawl performance in competitive swimmers. And improvements in swimming performance may simply resulted from resistance training increasing stroke rate rather than stroke length. In addition, the results of subgroup analysis showed that only concurrent resistance training (CRT) and power training (PT) ultimately improved swimming performance by increasing the maximum muscle strength of the upper limbs.ConclusionResistance training significantly enhances competitive swimmers’ upper limb strength and front crawl performance across various distances. The improvement in performance is likely attributed to an increased stroke rate rather than stroke length. In addition, CRT and PT are particularly effective, indicating the importance of selecting the appropriate methodology of resistance training for optimal swimming performance enhancement.Systematic review registrationhttps://doi.org/10.17605/OSF.IO/3JEGW.
Case report: Evaluation of cutaneous squamous cell carcinoma metastasized to lymph nodes using 18F-fluoro-2-deoxy-D-glucose positron emission tomography/computed tomography in a dog
Authors: Seok Jin , Lee Sungin 
Published: July 2024

Introduction18F-fluorodeoxy-2-deoxy-D-glucose (FDG) positron emission tomography (PET) is used with high sensitivity in human medicine for initial staging and treatment planning of cutaneous squamous cell carcinoma (SCC). To the best of our knowledge, 18F-FDG PET/computed tomography (CT) has not been used for canine cutaneous SCC with lymph node metastasis.Case presentationA 13 year-old spayed female Maltese had rapidly growing flank SCC, which had previously recurred twice. Radiography revealed no metastases. On PET/CT imaging, increased FDG uptake was observed not only in the flank but also in the left axillary lymph node and left inguinal lymph node (standardized uptake value max [SUVmax]: 8.602, 5.354, and 1.96, respectively). Despite the evidence of metastasis, palliative skin mass resection with a 3-cm margin and lymph node dissection were performed. Histopathological examination confirmed the presence of metastases in both lymph nodes.Discussion18F-FDG PET/CT is valuable for the detection of metastatic tumors in various organs. Cutaneous SCC can accumulate 18F-FDG, making it detectable on PET/CT. In this dog with flank SCC, 18F-FDG-PET/CT showed high SUVmax values, indicating its potential for tumor assessment. In veterinary medicine, SUVmax values of 2.5–3.5 are commonly used to identify metastatic lymph nodes in other cancers. Therefore, the interpretation of an SUVmax of 1.96 in an inguinal lymph node for metastatic involvement may be uncertain. Owing to the partial volume effect, 18F-FDG PET/CT has limited sensitivity in identifying LN metastases, particularly in cases of small lesions. Lower SUVmax values adjusted for smaller sizes may better distinguish between benign and malignant lymph nodes. Hence, combining differentiated SUVmax cut-offs based on lymph node size with CT assessment could enhance lymph node evaluation and assist in surgical planning.