bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Design, Synthesis and Antitubercular Evaluation of Novel 2‐Substituted‐3H‐benzofuro Benzofurans via Palladium—Copper Catalyzed Sonogashira Coupling Reaction.
Authors: Yempala Thirumal , Sridevi Jonnalagadda Padma , Yogeeswari Perumal , Sriram Darmarajan , Kantevari Srinivas 
Published: January 2014

AbstractCompound (Ve) is found to exhibit the best in vitro anti‐mycobacterial activity against Mycobacterium tuberculosis H37Rv with lower cytotoxicity and good therapeutic index.
ChemInform Abstract: Asymmetric Michael‐Aldol Tandem Reaction of 2‐Substituted Benzofuran‐3‐ones and Enones: A Facile Synthesis of Griseofulvin Analogues.
Authors: Dong Nan , Li Xin , Wang Feng , Cheng Jin‐Pei 
Published: January 2014

AbstractThis reaction sequence yields the spiro‐products with adjacent quaternary and tertiary stereocenters with excellent enantioselectivities.
ChemInform Abstract: Pd‐Catalyzed Oxidative Cross‐Coupling Between Two Electron Rich Heteroarenes.
Authors: He Chun‐Yang , Wang Zhen , Wu Cai‐Zhi , Qing Feng‐Ling , Zhang Xingang 
Published: January 2014

AbstractThe title reaction of two heteroaromatic cross‐coupling partners with similar structures and electronic properties under mild conditions is achieved.
ChemInform Abstract: Dual Selectivity: Electrophile and Nucleophile Selective Cross‐Coupling Reactions on a Single Aromatic Substrate.
Authors: Heinrich Annika C. J. , Thiedemann Birk , Gates Paul J. , Staubitz Anne 
Published: January 2014

AbstractThe first microwave assisted very high selective one‐pot Stille cross‐coupling of aromatic compounds yields bifunctional products.
ChemInform Abstract: Synthesis of Hexahydroisoindole‐3a‐carboxylates by IMDA Reaction of Morita—Baylis—Hillman Adduct‐Derived Dienes Bearing a Z‐Alkenyl Tether.
Authors: Kim Ko Hoon , Lee Sangku , Lee Junseong , Go Min Jeong , Kim Jae Nyoung 
Published: January 2014

AbstractAn intramolecular Diels—Alder (IMDA) reaction of Morita—Baylis—Hillman adduct‐derived dienes bearing a Z‐alkenyl dienophile tether affords hexahydroisoindole‐3a‐carboxylates in excellent yields and stereoselectivity.
ChemInform Abstract: A Convenient Approach to the Design and Synthesis of Indolo[3,2‐c]coumarins via the Microwave‐Assisted Cadogan Reaction.
Authors: Irgashev Roman A. , Karmatsky Arseny A. , Slepukhin Pavel A. , Rusinov Gennady L. , Charushin Valery N. 
Published: January 2014

AbstractMicrowave‐assisted Cadogan reaction of easily accessible 3‐(4,5‐dimethoxy‐2‐nitrophenyl)coumarins affords the corresponding indolo[3,2‐c]coumarins.
ChemInform Abstract: Catalyst‐Controlled C—O versus C—N Allylic Functionalization of Terminal Olefins.
Authors: Strambeanu Iulia I. , White M. Christina 
Published: January 2014

AbstractDepending on the reaction conditions and especially the reaction time, the substrates can be converted to either aminooxazolines or imidazolidinones (with the respective other being a side‐product in small amounts).
ChemInform Abstract: Synthesis and Biological Evaluation of Carbohydrate Appended Hydrazinocyclopentenes with Potent Glycation and α‐Glucosidase Inhibition Activities.
Authors: Ajish K. R. , Joseph Nayana , Rani M. Priya , Raghu K. G. , Vineetha V. P. , Radhakrishnan K. V. 
Published: January 2014

AbstractSynthesis and biological evaluation of novel alkylidenecyclopentene glycohybrids like (IV) are described.
ChemInform Abstract: Iridium‐Catalyzed Cycloaddition of Azides and 1‐Bromoalkynes at Room Temperature.
Authors: Rasolofonjatovo Evelia , Theeramunkong Sewan , Bouriaud Alexandra , Kolodych Sergii , Chaumontet Manon , Taran Frederic 
Published: January 2014

AbstractThe title mild reaction offers a direct route to new 1,4,5‐trisubstituted triazoles.
ChemInform Abstract: Zinc Mediated Azide—Alkyne Ligation to 1,5‐ and 1,4,5‐Substituted 1,2,3‐Triazoles.
Authors: Smith Christopher D. , Greaney Michael F. 
Published: January 2014

AbstractA regioselective method for the synthesis of different substituted triazole derivatives under mild reactions conditions is presented.
ChemInform Abstract: Ionic Liquids as Unique Solvents in One‐Pot Synthesis of 4‐(N,2,2,2‐Tetranitroethylamino)‐3‐R‐furazans.
Authors: Sheremetev Aleksei B. , Aleksandrova Nataly S. , Palysaeva Nadezhda V. , Struchkova Marina I. , Tartakovsky Vladimir A. , Suponitsky Kyrill Yu. 
Published: January 2014

AbstractThe prepared furazanes are thoroughly investigated by NMR spectroscopy and X‐ray crystallography.
ChemInform Abstract: Domino Reactions for the Synthesis of Anthrapyran‐2‐ones and the Total Synthesis of the Natural Product (.+‐.)‐BE‐26554A.
Authors: Rixson James E. , Skelton Brian W. , Koutsantonis George A. , Gericke Kersten M. , Stewart Scott G. 
Published: January 2014

AbstractThis straightforward approach gives access to a new series of anthrapyran‐2‐ones as well as to the antibiotic and antitumor compound (XII).
ChemInform Abstract: Enantioselective Synthesis of cis‐3‐Fluoropiperidin‐4‐ol, a Building Block for Medicinal Chemistry.
Authors: Shaw Simon J. , Goff Dane A. , Boralsky Luke A. , Irving Mark , Singh Rajinder 
Published: January 2014

AbstractBoth enantiomers of the title compound (III) are available with high enantioselectivities by using either quinine‐ or quinidine‐derived organocatalyst.
ChemInform Abstract: Synthesis of 1,4‐Dihydropyridine Derivatives via One Pot Multicomponent Condensation in Water.
Authors: Ghorbani‐Choghamarani Arash , Norouzi Masoomeh 
Published: January 2014

AbstractA novel series of Hantzsch‐pyridine derivatives is prepared by reaction of nano aluminum nitride and aromatic aldehydes with 3‐oxobutanoate derivatives (II) under catalyst‐free and eco‐friendly conditions.
ChemInform Abstract: A One Pot Microwave Assisted Synthesis of 3‐Acyl‐2,4‐dihydroxyquinoline (III) Followed by Synthesis of 7‐Methyldibenzo[c,f][2,7]naphthyridin‐6(5H)‐ones (V) via Three Routes.
Authors: Pitchai P. , Uvarani C. , Gengan R. M. , Mohan P. S. 
Published: January 2014

AbstractThe title compounds (V) are obtained by applying microwave and photochemical techniques under mild reaction conditions.
ChemInform Abstract: Stereoselective Synthesis of Functionalized Cyclic Amino Acid Derivatives via a [2,3]‐Stevens Rearrangement and Ring‐Closing Metathesis.
Authors: Nash Aaron , Soheili Arash , Tambar Uttam K. 
Published: January 2014

AbstractUnnatural cyclic amino acid derivatives are accessible through a palladium‐catalyzed tandem allylic amination/Stevens rearrangement followed by ring‐closing metathesis.
ChemInform Abstract: Stereoselective Total Synthesis of Xyolide.
Authors: Reddy B. V. Subba , Reddy P. Sivaramakrishna , Reddy B. Phaneendra , Yadav J. S. , Al Ghamdi Ahamad Al Khazim 
Published: January 2014

AbstractA stereoselective total synthesis of xyolide (I) is described employing MacMillan α‐hydroxylation, Steglich esterification, and ring closing metathesis as key steps.
ChemInform Abstract: A Highly Conjugated Benzimidazole Carbene‐Based Ruthenium Sensitizer for Dye‐Sensitized Solar Cells.
Authors: Li Wen‐Ren , et al. et al. 
Published: January 2014

AbstractCompared with the dye CBTR the conjugated thiophene on compound (I) enhances the molar extinction coefficient of the intraligand π—π* transition and the intensity of the lower energy metal to ligand transfer band.
ChemInform Abstract: Synthesis and Characterization of Azo‐3‐cyano‐iminocoumarin Dyes.
Authors: Bouattour A. , Fakhfakh M. , LeBigot Y. , Abid S. , Ammar H. 
Published: January 2014

AbstractA three‐step procedure based on the formation of azo aldehydes, Knoevenagel condensation and reaction with isocyanate or thioisocyanate derivatives paves the way towards the synthesis of new N‐substituted iminocoumarin derivatives (VII) and (IX).
ChemInform Abstract: Model Studies on Heterogeneous Catalysts at the Atomic Scale: From Supported Metal Particles to Two‐dimensional Zeolites
Authors: Freund Hans‐Joachim , Heyde Markus , Nilius Niklas , Schauermann Swetlana , Shaikhutdinov Shamil , Sterrer Martin 
Published: January 2014

AbstractReview: 108 refs.
Enantiomeric Separation of Underivatized Amino Acids: Predictability of Chiral Recognition on Ristocetin A Chiral Stationary Phase
Authors: Wagdy Hebatallah A. , Hanafi Rasha S. , El‐Nashar Rasha M. , Aboul‐Enein Hassan Y. 
Published: January 2014

ABSTRACTThe present work aimed to investigate the predictability of the chromatographic behavior for the separation of underivatized amino acids on ristocetin A, known as Chirobiotic R, using a DryLab high‐performance liquid chromatography (HPLC) method development software, which is typically used to predict the effect of changing various chromatographic parameters on resolution in the reversed phase mode. After implementing the basic runs, and judging the predictability via the computed resolution map, it can be deduced that the chiral recognition mechanisms tend towards a hydrophilic interaction chromatography rather than the reversed phase mode, which limits the ability of DryLab software to predict separations on Chirobiotic R. Chirality 26:132–135, 2014. © 2014 Wiley Periodicals, Inc.
Why do firms hold so much cash? An innovation explanation
Authors: Lin Shannon 
Published: January 2014

AbstractTheory holds that knowledge has positive economic consequences. While US corporations defend record high level cash holdings citing the precautionary motive in response to changing firm characteristics, I find that knowledge‐based innovation can partially explain these changes. Using distance to the nearest research university as a measure of knowledge intensity, I show that knowledge‐intensive firms hold more cash, even after controlling for firm R&D. Moreover, knowledge‐intensive firms exhibit higher marginal value of cash and save more cash from cash flows than their less knowledge‐intensive counterparts. Overall, the precautionary motive appears to dominate the agency motive, with the effect of knowledge on cash holdings strengthening over time. Copyright © 2014 ASAC. Published by John Wiley & Sons, Ltd.
Chromatic analysis of blue ballpoint pen inks and related dyes
Authors: Feraru Daniela Laura , Mihaly Maria , Meghea Aurelia 
Published: January 2014

AbstractAnalysis of ballpoint pen inks on questioned documents is often required in the field of forensic analysis to identify the writing implement used in the commitment of a crime. In forensic work, it is thus necessary to identify the manufacturer of the pen or the specific ink product.In this article, a forensic analysis is documented for discrimination of a series of ballpoint pastes to identify the chromatic components used for blue ballpoint pen inks and thus to establish the writing instrument used in a questioned document. To achieve this, data of various adequate techniques have been corroborated: X‐ray fluorescence spectroscopy, ultraviolet–visible–near‐infrared spectrophotometry, in diffuse reflection and transmission modes, completed by trichromatic analyses, and thin layer chromatography. A protocol consisting of four steps has been proposed, in which various components provided by a database of reference dyes are removed, selected, and combined to assess the possible identity of an unknown pen ink paste among a set belonging to the same color pallet. © 2014 Wiley Periodicals, Inc. Col Res Appl, 40, 169–177, 2015
Cross‐Linked Imidazolium Salts as Scavengers for Palladium
Authors: Buscemi Roberto , Giacalone Francesco , Orecchio Santino , Gruttadauria Michelangelo 
Published: January 2014

AbstractFive imidazolium‐based materials have been synthesised and used for the first time as palladium scavengers. Radical reactions of suitable bis‐vinylimidazolium salts led to a series of insoluble materials through homo‐polymerisation, immobilisation with a 3‐mercaptopropyl‐modified silica gel or co‐polymerisation with ethylene glycol dimethylacrylate. These materials were screened as palladium scavengers with a set of palladium(0) and palladium(II) compounds in different solvents and at different starting amounts of palladium. In many cases, residual amounts of palladium were lower than 5 ppm, as requested for the manufacture of active pharmaceutical ingredients and fine chemicals. The application of one of these materials as a palladium scavenger in a Suzuki coupling reaction resulted in a 29‐fold abatement of the palladium content in the final product with respect to the control reaction.
Correcting Psychotherapists' Blindsidedness: Formal Feedback as a Means of Overcoming the Natural Limitations of Therapists
Authors: Macdonald James , Mellor‐Clark John 
Published: January 2014

PurposeMonitoring of client progress in psychological therapy using formal outcome measures at each session has been shown to increase the effectiveness of treatment. It seems likely that this ‘feedback’ effect is achieved by enabling therapists to identify clients at risk of treatment failure so that therapists can pay greater attention to client difficulties, which may be hindering therapeutic work. To date, little attention has been given to understanding relevant mechanisms of formal feedback in psychological therapy. In order to understand and maximize the benefits of feedback, it is essential to explore potential mechanisms contributing to this effect. Research in social psychology may help to explain how feedback works.MethodsFindings on cognitive biases in the field of social psychology are explored and linked to preliminary findings in the field of psychotherapy research.ResultsResearch on cognitive biases and expertise is congruent with indications that clinical prediction in psychotherapy is unreliable and that it may be difficult for clinicians to detect errors in their judgement as a result of a lack of clear corrective feedback. This problem is linked to the fact that clinical outcomes occur in a complex ‘noisy’ environment where prediction is inherently difficult.ConclusionFormal feedback may derive its benefits from its ability to help correct naturally occurring biases in therapists' assessment of their work. If these biases are seen as normal, but often avoidable if feedback is used, this may pave the way to greater acceptance of formal feedback by clinicians and enhanced outcomes for clients. Copyright © 2014 John Wiley & Sons, Ltd.Key Practitioner Message

The use of formal feedback tools can help therapists overcome inevitable limitations in their ability to predict poor response to treatment, enhancing the likelihood of detecting and resolving client difficulties in therapy.
What shall I do now? State‐dependent variations of life‐history traits with aging in Wandering Albatrosses
Authors: Pardo Deborah , Barbraud Christophe , Weimerskirch Henri 
Published: January 2014

AbstractAllocation decisions depend on an organism's condition which can change with age. Two opposite changes in life‐history traits are predicted in the presence of senescence: either an increase in breeding performance in late age associated with terminal investment or a decrease due to either life‐history trade‐offs between current breeding and future survival or decreased efficiency at old age. Age variation in several life‐history traits has been detected in a number of species, and demographic performances of individuals in a given year are influenced by their reproductive state the previous year. Few studies have, however, examined state‐dependent variation in life‐history traits with aging, and they focused mainly on a dichotomy of successful versus failed breeding and non‐breeding birds. Using a 50‐year dataset on the long‐lived quasi‐biennial breeding wandering albatross, we investigated variations in life‐history traits with aging according to a gradient of states corresponding to potential costs of reproduction the previous year (in ascending order): non‐breeding birds staying at sea or present at breeding grounds, breeding birds that failed early, late or were successful. We used multistate models to study survival and decompose reproduction into four components (probabilities of return, breeding, hatching, and fledging), while accounting for imperfect detection. Our results suggest the possible existence of two strategies in the population: strict biennial breeders that exhibited almost no reproductive senescence and quasi‐biennial breeders that showed an increased breeding frequency with a strong and moderate senescence on hatching and fledging probabilities, respectively. The patterns observed on survival were contrary to our predictions, suggesting an influence of individual quality rather than trade‐offs between reproduction and survival at late ages. This work represents a step further into understanding the evolutionary ecology of senescence and its relationship with costs of reproduction at the population level. It paves the way for individual‐based studies that could show the importance of intra‐population heterogeneity in those processes.
Validation of adipose lipid content as a body condition index for polar bears
Authors: McKinney Melissa A. , Atwood Todd , Dietz Rune , Sonne Christian , Iverson Sara J. , Peacock Elizabeth 
Published: January 2014

AbstractBody condition is a key indicator of individual and population health. Yet, there is little consensus as to the most appropriate condition index (CI), and most of the currently used CIs have not been thoroughly validated and are logistically challenging. Adipose samples from large datasets of capture biopsied, remote biopsied, and harvested polar bears were used to validate adipose lipid content as a CI via tests of accuracy, precision, sensitivity, biopsy depth, and storage conditions and comparisons to established CIs, to measures of health and to demographic and ecological parameters. The lipid content analyses of even very small biopsy samples were highly accurate and precise, but results were influenced by tissue depth at which the sample was taken. Lipid content of capture biopsies and samples from harvested adult females was correlated with established CIs and/or conformed to expected biological variation and ecological changes. However, lipid content of remote biopsies was lower than capture biopsies and harvested samples, possibly due to lipid loss during dart retrieval. Lipid content CI is a biologically relevant, relatively inexpensive and rapidly assessed CI and can be determined routinely for individuals and populations in order to infer large‐scale spatial and long‐term temporal trends. As it is possible to collect samples during routine harvesting or remotely using biopsy darts, monitoring and assessment of body condition can be accomplished without capture and handling procedures or noninvasively, which are methods that are preferred by local communities. However, further work is needed to apply the method to remote biopsies.
Effect of comorbidities on outcomes and angiotensin converting enzyme inhibitor effects in patients with predominantly left ventricular dysfunction and heart failure
Authors: Böhm Michael , Pogue Janice , Kindermann Ingrid , Pöss Janine , Koon Teo , Yusuf Salim 
Published: January 2014

AimsComorbidities are frequent in heart failure and impact outcomes. It is not known whether comorbidities are associated with outcomes in asymptomatic left ventricular dysfunction compared to clinical heart failure and whether comorbidities interfere with treatment effects. Our objective was to assess comorbidities and their effects on outcomes in predominantly asymptomatic populations without previous heart failure treatment of the SOLVD prevention trial, compared to symptomatic heart failure patients of SOLVD treatment and to evaluate associations to the effect of enalapril.Methods and resultsThis post hoc analysis from the SOLVD prevention and SOLVD treatment trials includes 4228 patients with left ventricular dysfunction and 2569 patients with heart failure. The preexisting comorbidities hypertension, diabetes mellitus, pulmonary disease, angina pectoris, renal impairment, and anaemia were similar in SOLVD treatment and SOLVD prevention, with a higher prevalence in SOLVD treatment. Comorbidities are significantly associated with the primary composite of SOLVD time to death or heart failure hospitalization (SOLVD prevention: HR 4.8, CI: 3.2–7.18, P < 0.0001; SOLVD treatment: HR 2.9, CI: 2.12–3.95, P < 0.0001 for more than four comorbidities vs. no comorbidities), and to death, heart failure hospitalization, and cardiovascular death where the effect of the number of coexisting comorbidities was additive. There was no significant interaction of comorbidities with treatment effects of enalapril.ConclusionComorbidities increased events in asymptomatic left ventricular dysfunction and in symptomatic heart failure, but did not interfere with the effects of enalapril. Comorbidities need to be adequately addressed in clinical trials, which should also involve non‐cardiac treatments in order to improve outcome for heart failure patients.
Recognition of Salmonella by Dectin‐1 induces presentation of peptide antigen to type B T cells
Authors: Jackson Nicola , Compton Evan , Trowsdale John , Kelly Adrian P. 
Published: January 2014

Type B T cells recognize peptide–MHC class II (pMHCII) isoforms that are structurally distinct from those recognized by conventional type A T cells. These alternative type B conformers result from peptide loading in the absence of HLA‐DM. Type A conformers are more stable than type B pMHCII conformers but bind the same peptide in the same register. Here, we show that interaction of Salmonella Typhimurium with bone marrow derived dendritic cells (BMDCs) isolated from C3H/HeNCr1 mice results in enhanced presentation of peptide Ag to type B T cells. The effect could be mimicked by purified PAMPs, the most potent of which were curdlan and zymosan, β‐(1,3)‐glucan‐containing polymers that are recognized by Dectin‐1. Blocking of Dectin‐1 with Ab and laminarin inhibited the induction of the type B T‐cell response by BMDCs, confirming its role as a PRR for S. Typhimurium. Splenic DCs (sDCs) expressed Dectin‐1 but were refractive to the induction of type B responses by S. Typhimurium and curdlan. Type B T cells have been shown to escape thymic tolerance and to transfer pathology in an autoimmune disease model. The induction of type B responses by gram‐negative bacteria provides a mechanism by which autoreactive T cells may be produced during infection.
Two Series of Lanthanide Metal‐Organic Frameworks Constructed from Crown‐Ether‐Like Secondary Building Units
Authors: Wang Hao , Wen Rong‐Mei , Hu Tong‐Liang 
Published: January 2014

AbstractTwo series of lanthanide metal‐organic frameworks, [KLn3(FDCA)5(H2O)5]·solvent (1Ln) (Ln = La 1, Ce 2, Pr 3), [K4Ln8(FDCA)14(H2O)30]·2(H2FDCA)·DMAC·10(H2O) (2Ln) (Ln = Eu 4, Gd 5, Tb 6, Dy 7, Er 8, DMAC = N,N‐dimethylacetamide), have been prepared by solvothermal reactions of 2,5‐furandicarboxylic acid (H2FDCA) and KNO3 with the corresponding lanthanide nitrate. X‐ray crystal structure analyses show that 1Ln possesses a 3D network based on the “16‐crown‐6‐like” secondary building unit (SBU), whereas 2Ln exhibits a 1D framework with a “23‐crown‐9‐like” SBU. The structural investigation unambiguously demonstrated that the lanthanide contraction affects the formation of 1Ln and 2Ln. Meanwhile, the solid‐state photoluminescent properties of 4 and 6 were also investigated at room temperature and the luminescence intensity of 4 is sensitive to small molecules.