bluuebunny/crossref_metadata_2025_split huggingface dataset:
Lipid infusion in the management of poisoning: a report of 6 canine cases
Authors: Bates N. , Chatterton J. , Robbins C. , Wells K. , Hughes J. , Stone M. , Campbell A. 
Published: July 2013

Intravenous administration of lipid is a relatively new treatment in the management of toxicity from lipophilic compounds. It is used in human medicine in the treatment of toxicity from lipophilic local anaesthetics and cardiotoxic drugs and can result in dramatic improvement in clinical status. We present six cases of poisoning in dogs successfully treated with lipid infusion after ingestion of ivermectin (3), moxidectin (2) and baclofen (1). The dogs ranged in age from eight weeks to 14 years, and weighed 4–30 kg. Intravenous lipid therapy was started between six and eight hours and 22 hours after ingestion, and all the dogs responded well. In four dogs, there was clinical improvement within one hour; one had improved within two hours and the other within 4.5 hours of lipid administration. The only adverse effect of lipid infusion reported was mild swelling and pain after extravasation in one case which resolved with conservative management. All the dogs were discharged within 24–52 hours after exposure (7–46 hours after the start of lipid administration), and none developed any apparent sequelae.
Four BSE cases with an L‐BSE molecular profile in cattle from Great Britain
Authors: Stack M. J. , Chaplin M. J. , Davis L. A. , Everitt S. , Simmons M. M. , Windl O. , Hope J. , Burke P. 
Published: July 2013

Bovine spongiform encephalopathy (BSE) is a prion disease of cattle which was first observed in Great Britain (GB) in 1986. Throughout the subsequent BSE epidemic, cases identified by passive surveillance have shown consistent histopathological, immunohistochemical, biochemical and biological properties. However, since the start of active surveillance in 2001, across Europe and elsewhere, approximately 67 cases with different biochemical characteristics have been identified by Western blotting (WB). These cases fall into two categories; ‘H‐type’ (H‐BSE) or ‘L‐type’ (L‐BSE), based on the relatively heavy (H‐BSE) or light (L‐BSE) mass of the unglycosylated band of the prion protein, as compared with WB against that obtained from classical BSE (C‐BSE) cases. Here we report the detection and confirmation of the first four L‐BSE cases by active surveillance in GB, two of which were born after the reinforced feed ban of 1996 (BARB cases). These four L‐BSE cases were found in relatively old cattle (age range; 11–21 years old) and the carcases did not enter the human food chain or animal feed chains.
Retained surgical swabs in 13 dogs
Authors: Forster K. , Anderson D. , Yool D. A. , Wright C. , Burrow R. 
Published: July 2013

To report the signalment, history, clinical signs, diagnostic and surgical findings and outcome in dogs and cats with retained swabs, medical records of dogs and cats that were referred to four referral centres were reviewed. Cases in which a retained surgical swab was identified during surgery at the referral hospital were selected for further study. The signalment, history, clinical signs, diagnostic and surgical findings and outcome in these cases were reviewed. Thirteen dogs with retained surgical swabs were included in the study. Bodyweight ranged from 9 to 45 kg. The initial surgery was a ‘non‐routine’ abdominal procedure in seven dogs, ovariohysterectomy in five dogs and perineal hernia repair in one dog. Time from initial surgery to presentation at the referral centre ranged from four days to seven years. Treatment involved major surgery in eight of the 13 dogs. Outcome was excellent in 12 of 13 cases, one dog was euthanased.
Review of seven cases of granulosa cell tumour of the equine ovary
Authors: Crabtree J. 
Published: July 2013

This paper reviews the equine granulosa cell tumour (GCT) and describes the clinicopathological features, treatment and outcome in seven cases of GCT in mares. Mares were presented with unilateral ovarian enlargement during the 2007 to 2010 breeding seasons. The mean (sd) age of the mares was 11.7 (5.96) years. Three mares were multiparous barren, three were nulliparous and one was primigravida. Behaviour at presentation was 57 per cent anoestrus, 28 per cent with stallion‐like behaviour and 14 per cent with persistent oestrus. All mares had unilateral ovarian enlargement. Six non‐pregnant mares had a small and inactive contralateral ovary; the pregnant mare had a single small corpus luteum on the contralateral ovary and was at three‐and‐a‐half months' gestation. Enlarged ovaries measured 7 cm to an estimated 30 cm in diameter. 28 per cent had a multicystic ultrasound appearance, 57 per cent were dense structures and 14 per cent were of mixed appearance. Mean concentrations of progesterone were <1 ng/ml, oestrone sulphate 3.06 (2.32) ng/ml and testosterone 0.58 (0.64) nmol/l in non‐pregnant mares. Inhibin was elevated in all non‐pregnant cases at 7.6 (12.45) ng/ml. The pregnant mare had concentrations of progesterone 2.5 ng/ml, oestrone sulphate 81.0 ng/ml, testosterone 1.9 nmol/l and inhibin 1.31 ng/ml. Mares demonstrating stallion‐like behaviour had a significantly higher (P<0.001) testosterone concentration (1.85 [0.07] nmol/l) than those that did not (0.34 [0.26] nmol/l). Three mares underwent unilateral ovariectomy and resumed cyclic ovarian activity within nine months of surgery.
TauDecay: a library to simulate polarized tau decays via FeynRules and MadGraph5
Authors: Hagiwara Kaoru , Li Tong , Mawatari Kentarou , Nakamura Junya 
Published: July 2013

AbstractTauDecay is a library of helicity amplitudes to simulate polarized tau decays, constructed in the FeynRules and MadGraph5 framework. Together with the leptonic mode, the decay library includes the main hadronic modes, τ→ντ+π, 2π, and 3π, which are introduced as effective vertices by using FeynRules. The model file allows us to simulate tau decays when the on-shell tau production is kinematically forbidden. We also demonstrate that all possible correlations among the decay products of pair-produced taus through a Z boson and a scalar/pseudoscalar Higgs boson are produced automatically. The program has been tested carefully by making use of the standard tau decay library Tauola.
The influence of the provenance of arenite on its diagenesis in the Cameros Rift Basin (Spain)
Authors: Arribas J. , González-Acebrón L. , Omodeo-Salé S. , Mas R. 
Published: July 2013

Abstract
The intraplate Cameros Rift Basin in northern Spain, which has sediments some 6500 m thick, developed between the Late Jurassic and Early Albian. Its facies and their distribution in the sedimentary record suggest the basin may contain hydrocarbon systems. The arenite composition of the basin reveals two main petrofacies: (1) a quartzolithic petrofacies, the provenance of which is related to recycling processes that took place in the pre-rift sedimentary cover; and (2) a quartzofeldspathic petrofacies mainly related to the erosion of a plutonic and metamorphic source of arenite. The succession of these petrofacies reflects two main cycles representing the progressive erosion of their sources, one of 10 Ma, the other of 30 Ma. Such succession is typical of a non-volcanic rift basin. The quartzolithic petrofacies shows early carbonate cements that inhibited compaction and later quartz, feldspar and clay mineral diagenetic phases. The quartzofeldspathic petrofacies has a rigid framework that maintained the original pores of the arenite during burial diagenesis. Quartz and K-feldspar overgrowths are common, with secondary porosity occurring as a product of feldspar dissolution. The quartzofeldspathic petrofacies has a greater potential to act as a hydrocarbon reservoir. This study corroborates the close relationship between the provenance of arenite and its reservoir potential in continental rift basins.
An F876L Mutation in Androgen Receptor Confers Genetic and Phenotypic Resistance to MDV3100 (Enzalutamide)
Authors: Korpal Manav , Korn Joshua M. , Gao Xueliang , Rakiec Daniel P. , Ruddy David A. , Doshi Shivang , Yuan Jing , Kovats Steve G. , Kim Sunkyu , Cooke Vesselina G. , Monahan John E. , Stegmeier Frank , Roberts Thomas M. , Sellers William R. , Zhou Wenlai , Zhu Ping 
Published: July 2013

Abstract
Castration-resistant prostate cancer (CRPC) is the most aggressive, incurable form of prostate cancer. MDV3100 (enzalutamide), an antagonist of the androgen receptor (AR), was approved for clinical use in men with metastatic CRPC. Although this compound showed clinical efficacy, many initial responders later developed resistance. To uncover relevant resistant mechanisms, we developed a model of spontaneous resistance to MDV3100 in LNCaP prostate cancer cells. Detailed characterization revealed that emergence of an F876L mutation in AR correlated with blunted AR response to MDV3100 and sustained proliferation during treatment. Functional studies confirmed that ARF876L confers an antagonist-to-agonist switch that drives phenotypic resistance. Finally, treatment with distinct antiandrogens or cyclin-dependent kinase (CDK)4/6 inhibitors effectively antagonized ARF876L function. Together, these findings suggest that emergence of F876L may (i) serve as a novel biomarker for prediction of drug sensitivity, (ii) predict a “withdrawal” response to MDV3100, and (iii) be suitably targeted with other antiandrogens or CDK4/6 inhibitors.
Significance: We uncovered an F876L agonist-switch mutation in AR that confers genetic and phenotypic resistance to the antiandrogen drug MDV3100. On the basis of this finding, we propose new therapeutic strategies to treat patients with prostate cancer presenting with this AR mutation. Cancer Discov; 3(9); 1030–43. ©2013 AACR.
See related commentary by Nelson and Yegnasubramanian, p. 971
This article is highlighted in the In This Issue feature, p. 953
ERK Pathway Inhibitors: How Low Should We Go?
Authors: Nissan Moriah H. , Rosen Neal , Solit David B. 
Published: July 2013

Abstract
Summary: Resistance to RAF inhibitors is generally accompanied by reactivation of extracellular signal-regulated kinase (ERK) signaling. SCH772984, a selective, ATP-competitive inhibitor of ERK1 and ERK2, is effective in BRAF-mutant models in which resistance is the result of ERK reactivation. SCH772984 may also have a role in the treatment of tumors in which ERK is dysregulated by mutant RAS, NF1, or activated receptor tyrosine kinases, settings in which current RAF inhibitors are ineffective. Cancer Discov; 3(7); 719–21. ©2013 AACR.
See related article by Morris et al., p. 742
Scanning for Clues to Better Use Selective Estrogen Receptor Modulators
Authors: Machiela Mitchell J. , Chanock Stephen J. 
Published: July 2013

Abstract
Summary: Ingle and colleagues present timely findings identifying genetic variants associated with response to selective estrogen receptor modulator therapy that when substantiated in follow-up may represent an important step toward understanding estrogen-dependent induction of BRCA1 expression and advancing individualized preventive medicine in women at high risk for developing breast cancer. Cancer Discov; 3(7); 728–9. ©2013 AACR.
See related article by Ingle et al., p. 812
Mitochondrial DNA Damage Can Promote Atherosclerosis Independently of Reactive Oxygen Species Through Effects on Smooth Muscle Cells and Monocytes and Correlates With Higher-Risk Plaques in Humans
Authors: Yu Emma , Calvert Patrick A. , Mercer John R. , Harrison James , Baker Lauren , Figg Nichola L. , Kumar Sheetal , Wang Julie C. , Hurst Liam A. , Obaid Daniel R. , Logan Angela , West Nick E.J. , Clarke Murray C.H. , Vidal-Puig Antonio , Murphy Michael P. , Bennett Martin R. 
Published: July 2013

Background—
Mitochondrial DNA (mtDNA) damage occurs in both circulating cells and the vessel wall in human atherosclerosis. However, it is unclear whether mtDNA damage directly promotes atherogenesis or is a consequence of tissue damage, which cell types are involved, and whether its effects are mediated only through reactive oxygen species.

Methods and Results—

mtDNA damage occurred early in the vessel wall in apolipoprotein E–null (ApoE
−/−
) mice, before significant atherosclerosis developed. mtDNA defects were also identified in circulating monocytes and liver and were associated with mitochondrial dysfunction. To determine whether mtDNA damage directly promotes atherosclerosis, we studied ApoE
−/−
mice deficient for mitochondrial polymerase-γ proofreading activity (polG
−/−
/ApoE
−/−
). polG
−/−
/ApoE
−/−
mice showed extensive mtDNA damage and defects in oxidative phosphorylation but no increase in reactive oxygen species. polG
−/−
/ApoE
−/−
mice showed increased atherosclerosis, associated with impaired proliferation and apoptosis of vascular smooth muscle cells, and hyperlipidemia. Transplantation with polG
−/−
/ApoE
−/−
bone marrow increased the features of plaque vulnerability, and polG
−/−
/ApoE
−/−
monocytes showed increased apoptosis and inflammatory cytokine release. To examine mtDNA damage in human atherosclerosis, we assessed mtDNA adducts in plaques and in leukocytes from patients who had undergone virtual histology intravascular ultrasound characterization of coronary plaques. Human atherosclerotic plaques showed increased mtDNA damage compared with normal vessels; in contrast, leukocyte mtDNA damage was associated with higher-risk plaques but not plaque burden.

Conclusions—
We show that mtDNA damage in vessel wall and circulating cells is widespread and causative and indicates higher risk in atherosclerosis. Protection against mtDNA damage and improvement of mitochondrial function are potential areas for new therapeutics.
Endothelial-Like Progenitor Cells Engineered to Produce Prostacyclin Rescue Monocrotaline-Induced Pulmonary Arterial Hypertension and Provide Right Ventricle Benefits
Authors: Zhou Lei , Chen Zhiqiang , Vanderslice Peter , So Shui-Ping , Ruan Ke-He , Willerson James T. , Dixon Richard A.F. 
Published: July 2013

Background—
Intravenous prostacyclin is approved for treating pulmonary arterial hypertension (PAH), but it has a short half-life and must be delivered systemically via an indwelling intravenous catheter. We hypothesize that localized jugular vein delivery of prostacyclin-producing cells may provide sustained therapeutic effects without the limitations of systemic delivery.

Methods and Results—
We generated a vector expressing a human cyclooxygenase isoform 1 and prostacyclin synthase fusion protein that produces prostacyclin from arachidonic acid. Endothelial-like progenitor cells (ELPCs) were transfected with the cyclooxygenase isoform 1-prostacyclin synthase plasmid and labeled with lentivirus expressing nuclear-localized red fluorescent protein (nuRFP). The engineered ELPCs (expressing cyclooxygenase isoform 1-prostacyclin synthase and nuRFP) were tested in rats with monocrotaline (MCT)-induced PAH. In PAH prevention studies, treatment with engineered ELPCs or control ELPCs (expressing nuRFP alone) attenuated MCT-induced right ventricular systolic pressure increase, right ventricular hypertrophy, and pulmonary vessel wall thickening. Engineered ELPCs were more effective than control ELPCs in all variables evaluated. In PAH reversal studies, engineered ELPCs or control ELPCs increased the survival rate of rats with established PAH and decreased right ventricular hypertrophy. Engineered ELPCs provided a survival benefit 2 weeks earlier than did control ELPCs. Microarray-based gene ontology analysis of the right ventricle revealed that a number of MCT-altered genes and neurotransmitter pathways (dopamine, serotonin, and γ-aminobutyric acid) were restored after ELPC-based prostacyclin gene therapy.

Conclusions—
Cyclooxygenase isoform 1-prostacyclin synthase–expressing ELPCs reversed MCT-induced PAH. A single jugular vein injection offered survival benefits for at least 4 weeks and may provide a promising option for PAH patients.
Korean Dramas and Films: Key Factors for Their International Competitiveness
Authors: Parc Jimmyn , Hwy-Chang Moon 
Published: July 2013

Abstract
The Korean wave, which is the popularity of Korean entertainment outside Korea, is a fairly new phenomenon. Encompassing Korean dramas, films, and songs, it has been highlighted by international media outlets and scholars. Several prestigious newspapers and scholars attempted to explain the competitiveness of the Korean wave, but they have remained biased by missing, overemphasizing, or overlapping important success factors. To provide a more comprehensive and accurate analysis, this paper conducts a rigorous study on the competitiveness of Korean entertainment industry focused on Korean dramas and films with a comprehensive analytical tool, the generalized double diamond model. The results of this study provide evidences that the Korean wave is not a temporary phenomenon but a sustainable industry segment. For further enhancement of this important industry, this paper suggests useful implications, including international cooperation with other countries.
South Korea during the Park Chung Hee Era: Explaining Korea’s Developmental Decades
Authors: Gemici Kurtuluş 
Published: July 2013

Abstract
Despite the voluminous literature on South Korea’s rapid economic development and social transformation in the 1960s and 1970s, the literature in English on Park Chung Hee — the political figure who indelibly marked this era — is still lacking. Furthermore, the existing studies approach the subject of Korea’s fateful decades from general theoretical perspectives, such as the developmental state. This approach inevitably flattens out historical particularity in the process. A recent edited volume, The Park Chung Hee Era: The Transformation of South Korea, fills these gaps by bringing political history back into the study of Korean modernization. The goal of this review essay is a critical evaluation of this volume’s contribution to scholarship on South Korea. It is posited that The Park Chung Hee Era throws light on topics such as Park’s leadership that have been hitherto neglected in the analysis of arguably the most consequential decades in the history of South Korea. However, while the edited volume mounts an effective criticism of existing perspectives on Korea’s developmental decades under Park Chung Hee’s rule, it is less successful in offering a consistent framework to analyze different causal factors shaping the Korean trajectory of economic development.
China’s Population Policy at the Crossroads: Social Impacts and Prospects
Authors: Jiang Quanbao , Jiang Quanbao , Li Shuzhuo , Jiang Quanbao , Li Shuzhuo , Feldman Marcus W. 
Published: July 2013

Abstract
China’s total fertility rate fell below replacement level in the 1990s. From the 1970s the fertility rate declined dramatically, mainly as a consequence of the national population policy whose aim has been to limit birth numbers, control population growth and boost economic growth. Having achieved such a low fertility rate, how will China’s population policy evolve in the future? This paper first reviews the history of China’s population policy since 1970 in three stages: 1970–1979; 1980–1999; and after 2000. We explore the impacts of China’s population policy, including relief of pressure on China’s environment and resources, fertility decline, the unexpectedly high male-biased sex ratio at birth (SRB), the coming shortage of labour force, and the rapid aging of the population, and extinction of racial and cultural diversity. We also investigate ethical issues raised by the implementation of the policy and its results. Finally we introduce the controversy over potential adjustment of the policy, acknowledging the problems faced by western countries with low fertility and the counter-measures they have taken. We offer some suggestions that might be appropriate in the Chinese context.
Experience as the Invisible Drive of Historical Writing
Authors: Simon Zoltán Boldizsár 
Published: July 2013

Abstract
From time to time our tiny intellectual worlds are simultaneously shaken by big ideas – ideas that, however big they are, have their expiration-date. Such is the case with the idea of the impossibility to find life outside language. In this essay, I picture what I think is the current state of the philosophy of history after the so-called linguistic turn and what I think the direction is where the philosophy of history might be headed by taking into account the important job done by linguistic theories. I regard the abandonment of epistemology and the arrival to the realm of aesthetics as a point of no return, and conclude that a new philosophy of history has to have an aesthetic character. However, due to the omnipotence of language I also detect a narrow constructive potential in linguistic theories and argue that a new philosophy of history has to have the dual task of searching for life outside language while remaining in the realm of aesthetics. As a next step, I identify Frank Ankersmit’s notion of an individual historical experience as a move towards the fulfillment of this dual task. Finally, because Ankersmit’s experience remains mute, in the second half of the essay I attempt to present an outline of the possibility of a fruitful cooperation between the philosophy of history and phenomenology. More precisely, I am trying to synchronize Ankersmit’s notion of an individual historical experience with László Tengelyi’s phenomenological experiments with experience and let Tengelyi speak where Ankersmit “stops talking”. As a result, with the help of Tengelyi, an aperture can be found in language through which experience might worm its way. Due to this fissure, experience might be regarded as an invisible driving force behind linguistic expressions, and thus behind historical writing.
An Anti-Christian Polemical Piyyut by Yosef Ibn Avitur Employing Elements from Toledot Yeshu
Authors: Rand Michael 
Published: July 2013

Abstract
This article presents a critical edition of the piyyut האומרים אב ובן ורוח שלישי for Yom Kippur by Yosef ibn Avitur (tenth-eleventh centuries). This piyyut, which contains an explicit anti-Christian polemic, is examined in light of two antecedents belonging to the same type. Furthermore, Avitur’s piyyut displays literary elements that are attested in the complex known as Toledot Yeshu—especially the epithet ממזר ובן נידה referring to Jesus himself as well as a reference to him having been crucified “on a cabbage stalk.” These elements are analyzed and conclusions are drawn with regard to their implication for the study of the evolution of the Toledot Yeshu literature.
A Persecution was Decreed: Persecution as a Rhetorical Device in the Literature of the Ge’Onim and Rishonim Part 2
Authors: Ringer Albert 
Published: July 2013

Abstract
It is a common misconception that the haftarah started as a replacement for the reading of the Torah. This idea has its modern source in an influential article published in 1927 by Jacob Mann. Going back to rabbinical and medieval sources shows that we should read them as topological texts. They give a pseudo-historical basis to well known and loved features of the service, like the haftarah, thereby missing a straightforward Talmudic source. Furthermore, they also seem to be in dialog with other medieval texts that speak about martyrdom as a reaction to repression.