bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Organocatalytic Aza‐Michael—Michael Cascade Reactions: A Flexible Approach to 2,3,4‐Trisubstituted Tetrahydroquinolines.
Authors: Jia Zhen‐Xin , Luo Yong‐Chun , Wang Yao , Chen Liang , Xu Peng‐Fei , Wang Binghe 
Published: March 2013

AbstractThe title compounds can be easily transformed into various ring‐fused tetrahydroquinolines.
ChemInform Abstract: Copper‐Catalyzed Amination of Silyl Ketene Acetals with N‐Chloroamines.
Authors: Miura Tomoya , Morimoto Masao , Murakami Masahiro 
Published: March 2013

AbstractThe reaction allows a new and convenient access to α‐amino esters and a one‐pot synthesis from amines is possible.
ChemInform Abstract: An Efficient Cyanosilylation of Aldehydes with Trimethylsilyl Cyanide Catalyzed by MgI2 Etherate.
Authors: Wang Yanping , Feng Meiling , Liu Yingshuai , Zhang Xingxian 
Published: March 2013

AbstractVarious aliphatic and aromatic aldehydes produce the desired cyanohydrin products with good to excellent yields.
ChemInform Abstract: Tandem Base‐Free Synthesis of β‐Hydroxy Sulfides under Ultrasound Irradiation.
Authors: Lv Guang‐Shu , Duan Fu‐Jun , Ding Jin‐Chang , Cheng Tian‐Xing , Gao Wen‐Xia , Chen Jiu‐Xi , Wu Hua‐Yue 
Published: March 2013

AbstractAn efficient and simple method for the regioselective synthesis of β‐hydroxy sulfides via Rongalite‐promoted reaction of epoxides with diaryl disulfides under ultrasound irradiation is developed.
ChemInform Abstract: Tandem Carbon—Carbon Bond Insertion and Intramolecular Aldol Reaction of Benzyne with Aroylacetones: Novel Formation of 4,4′‐Disubstituted 1,1′‐Binaphthols.
Authors: Okuma Kentaro , Itoyama Ryoichi , Sou Ayumi , Nagahora Noriyoshi , Shioj Kosei 
Published: March 2013

AbstractThe reaction mostly affords mixtures of 3‐substituted 1‐naphthols (III) and 4‐substituted 2‐naphthols (IV).
ChemInform Abstract: Fused Benzo[b]fluorenols: Palladium‐Catalyzed Intramolecular Dehydroaromatization and Carbonyl Reduction.
Authors: Zhao Quansheng , Hu Qiong , Wen Lei , Wu Min , Hu Yimin 
Published: March 2013

AbstractThe target compounds are prepared under conditions A) in the presence of propargyl bromide as an optimal reactant.
ChemInform Abstract: CuI‐Mediated Sequential Iodination/Cycloetherification of o‐Arylphenols: Synthesis of 2‐ or 4‐Iododibenzofurans and Mechanistic Studies.
Authors: Zhao Jiaji , Zhang Qi , Liu Lanying , He Yimiao , Li Jing , Li Juan , Zhu Qiang 
Published: March 2013

AbstractThe title reaction provides an efficient approach to a number of 2‐ and 4‐iododibenzofurans.
ChemInform Abstract: Synthesis of Substituted Thiophenes by Palladium‐Catalyzed Heterocyclodehydration of 1‐Mercapto‐3‐yn‐2‐ols in Conventional and Nonconventional Solvents.
Authors: Gabriele Bartolo , Mancuso Raffaella , Veltri Lucia , Maltese Vito , Salerno Giuseppe 
Published: March 2013

AbstractThe reaction provides a convenient, mild, and widely applicable method to prepare substituted thiophenes under either conditions A) or B).
ChemInform Abstract: A Metal‐Free Sulfenylation and Bromosulfenylation of Indoles: Controllable Synthesis of 3‐Arylthioindoles and 2‐Bromo‐3‐arylthioindoles.
Authors: Huang Dayun , Chen Jiuxi , Dan Weixing , Ding Jinchang , Liu Miaochang , Wu Huayue 
Published: March 2013

AbstractThe amount of NBS [cf.
ChemInform Abstract: A One‐Pot Regioselective Synthesis of Benzo[d]imidazo[2,1‐b]thiazoles.
Authors: Zhang Xinhai , Jia Jiong , Ma Chen 
Published: March 2013

AbstractA series of benzo[d]imidazo[2,1‐b]thiazoles (III), (V), (VII), (IX) and (XIII)/(XIV) are synthesized by a novel metal‐free synthesis.
ChemInform Abstract: Energetic Materials Containing Fluorine: Design, Synthesis and Testing of Furazan‐Containing Energetic Materials Bearing a Pentafluorosulfanyl Group.
Authors: Martinez Henry , Zheng Zhaoyun , Dolbier William R. Jr. 
Published: March 2013

AbstractThe impact of a pentafluorosulfanyl substituent on the properties of furazan‐containing energetic materials is studied.
ChemInform Abstract: Functionalizations of Aryl C—H Bonds in 2‐Arylpyridines via Sequential Borylation and Copper Catalysis.
Authors: Niu Liting , Yang Haijun , Yang Daoshan , Fu Hua 
Published: March 2013

AbstractThe procedure is used for the synthesis of iodides, azides, amines, sulfones and bromides and exclusive ortho‐substitution of the arene ring takes place.
ChemInform Abstract: Facile Assembly of Cyclopenta[c]quinolin‐3‐ols via a Palladium‐Catalyzed Reaction of 2‐Alkynylaniline with 2‐Alkynylvinyl Bromide.
Authors: Ye Chao , Qiu Guanyinsheng , Pan Xiaolin , Peng Yiyuan , Wu Jie 
Published: March 2013

AbstractThe title compounds (III) are prepared via a tandem reaction consisting of palladium‐catalyzed C‐C bond formation, ring closure, C‐N coupling and subsequent hydroxylation in a one‐pot procedure.
ChemInform Abstract: Cannizzaro Reaction of 2‐Chloro‐3‐formylquinolines and Its Synthetic Utility for 2‐Acetylfuro[2,3‐b]quinolines: The Alkaloid Analogues.
Authors: Kumar Devadoss Karthik , Shankar Rajakandhan , Rajendran Subramaniam Parameswaran 
Published: March 2013

AbstractAn efficient synthesis of 2‐acetylfuro[2,3‐b]quinolines through the acid‐catalyzed condensation reaction of 2‐methoxy‐3‐formylquinolines with acetone followed by bromocyclization and dehydrobromination is presented.
ChemInform Abstract: Bromenium‐Catalyzed Tandem Ring Opening/Cyclization of Vinylcyclopropanes and Vinylcyclobutanes: A Metal‐Free [3 + 2 + 1]/[4 + 2 + 1] Cascade for the Synthesis of Chiral Amidines and Computational Investigation.
Authors: Ganesh Venkataraman , Sureshkumar Devarajulu , Chanda Debasree , Chandrasekaran Srinivasan 
Published: March 2013

AbstractThis is a versatile method for highly stereoselective preparation of bicyclo[4.4.0]‐, [4.3.0]‐ and [4.3.1] amidines.
ChemInform Abstract: Tandem Supramolecular Synthesis of Substituted 2‐Aryl‐2,3‐dihydroquinazolin‐4(1H)‐ones in the Presence of β‐Cyclodextrin in Water.
Authors: Ramesh K. , Karnakar K. , Satish G. , Reddy K. Harsha Vardhan , Nageswar Y. V. D. 
Published: March 2013

AbstractThe eco‐friendly one‐pot method renders possible the synthesis of a broad spectrum of pharmacologically important title compounds.
ChemInform Abstract: Synthesis of Ynone Trifluoroborates Toward Functionalized Pyrazoles.
Authors: Kirkham James D. , Edeson Steven J. , Stokes Stephen , Harrity Joseph P. A. 
Published: March 2013

AbstractCoupling of novel ynone trifluoroborates like (III) with hydrazines provides a new, efficient, and regioselective approach to pyrazole trifluoroborates as precursors of diverse pyrazole derivatives.
ChemInform Abstract: Facile Synthesis of Benzimidazolin‐2‐chalcogenones: Nature of the Carbon—Chalcogen Bond.
Authors: Manjare Sudesh T. , Sharma Sagar , Singh Harkesh B. , Butcher Ray J. 
Published: March 2013

AbstractThe target compounds are prepared using Na2E2 (E=S, Se, Te) under basic conditions [cf.
ChemInform Abstract: Catalysis‐Based Enantioselective Total Synthesis of Myxothiazole Z, (14S)‐Melithiazole G and (14S)‐Cystothiazole F.
Authors: Colon Aude , Hoffman Thomas J. , Gebauer Julian , Dash Jyotirmayee , Rigby James H. , Arseniyadis Stellois , Cossy Janine 
Published: March 2013

AbstractMelithiazole G (VII) is prepared via a sequence involving cross‐metathesis of alkenes (I) and (II), asymmetric transfer hydrogenation of olefin (IV), and Stille coupling reaction of bromide (III) as the key steps.
Enantiomeric Separation of Original Heterocyclic Organophosphorus Compounds in Supercritical Fluid Chromatography
Authors: West Caroline , Cieslikiewicz‐Bouet Monika , Lewinski Krzysztof , Gillaizeau Isabelle 
Published: March 2013

ABSTRACTNew and original heterocyclic α‐enamido phosphine chiral solutes were prepared: four structurally similar racemates with the chirality center placed on the phosphorus atom, and four other related pairs of enantiomers with chirality borne by the carbon atoms of the phospholane ring. The structural variations were placed on an aliphatic heterocycle (six‐ or seven‐member rings) and on the carbamate function (methyl or t‐butyl). Their separation was achieved on a commercial cellulose tris‐(3,5‐dimethylphenylcarbamate) stationary phase (Lux Cellulose‐1, Phenomenex) in supercritical fluid chromatography (SFC). The effects of molecular structure on SFC retention and enantioresolution were studied. Among these eight pairs of enantiomers, some reversal of elution order between similar compounds was observed. The effect of changing the organic solvent (methanol and ethanol) and its proportion (between 5 and 40%) in the mobile phase was investigated. Retention data were collected over the temperature range 0–50 °C, and the results interpreted from thermodynamic aspects. Chirality, 2013. © 2013 Wiley Periodicals, Inc.
Pesticide Residues in the Danube River Basin in Serbia – a Survey during 2009–2011
Authors: Antić Nikolina , Radišić Marina , Radović Tanja , Vasiljević Tatjana , Grujić Svetlana , Petković Anđelka , Dimkić Milan , Laušević Mila 
Published: March 2013

AbstractIn this work, a total of 38 pesticides was monitored in the Danube River Basin in Serbia during ten sampling campaigns in 2009, 2010, and 2011. The quantification of analytes was performed using procedures based on solid‐phase extraction (SPE) followed by LC–MS/MS or GC–MS. In general, low pesticide levels were found, except for the samples collected during May–June of 2010 and June of 2011. During this period, pesticide application is high and rainfall was described as extremely above normal or above normal, leading to very pronounced runoff and very high detected pesticide levels. At the sampling site Smederevo (the Danube River), high concentrations of terbuthylazine (200 ng L−1) and metolachlor (150 ng L−1) were found. In the Danube tributary Morava, high concentrations of carbendazim (269 ng L−1), atrazine (188 ng L−1), terbuthylazine (180 ng L−1), and acetochlor (110 ng L−1) were detected, while in the tributary Tisa only terbuthylazine was present at high levels (130 ng L−1). In other sampling campaigns, pesticides were present at low concentrations. The most frequently found pesticide was carbendazim, probably due to slow degradation rate in environment.
Hepatic manifestations of metabolic syndrome
Authors: Medina‐Santillán Roberto , López‐Velázquez Jorge A. , Chávez‐Tapia Norberto , Torres‐Villalobos Gonzalo , Uribe Misael , Méndez‐Sánchez Nahum 
Published: March 2013

AbstractThe prevalence of metabolic syndrome is growing around the world at an alarming rate. Obesity involves a plethora of molecules that predispose individuals to an inflammatory state and various metabolic complications. Dysregulation of nutrient metabolism is a key step during the progression of chronic liver disease that induces an inflammatory state, cellular damage, and impaired hepatic insulin signaling, which leads to insulin resistance. Insulin resistance arises from multiple defects in the liver, adipose tissues, and muscle signaling, which leads to a failure to suppress hepatic gluconeogenesis and glycogenolysis, thereby enhancing fat accumulation in the hepatocytes via increased lipolysis and increased hepatic synthesis of triglycerides. This metabolic condition also increases the frequency of other comorbidities such as liver and biliary diseases. Nonalcoholic fatty liver disease is the hepatic expression of metabolic syndrome, which comprises a spectrum of clinical and histological events ranging from simple and benign fatty liver to steatohepatitis, which is characterized by the abnormal activation of pathways leading to an aggressive inflammatory condition. This pathological state may progress to more severe damage known as cirrhosis, which endangers the anatomy and function of liver tissue. In addition, a small group of patients with end‐stage liver disease may develop hepatocellular carcinoma and finally death. By contrast, cholesterol gallstone disease is a common metabolic disease, and is considered to be the main biliary indicator of metabolic syndrome. This review provides a detailed summary of the hepatic manifestations associated with metabolic syndrome. Copyright © 2013 John Wiley & Sons, Ltd.
Commentary on ‘Behavioural and cognitive‐behavioural group‐based parenting programmes for early‐onset conduct problems in children aged 3 to 12 years’
Authors: Haroon Munib 
Published: March 2013

AbstractThis is a commentary on a Cochrane review, published in this issue of EBCH, first published as: Furlong M, McGilloway S, Bywater T, Hutchings J, Smith SM, Donnelly M. Behavioural and cognitive‐behavioural group‐based parenting programmes for early‐onset conduct problems in children aged 3 to 12 years. Cochrane Database of Systematic Reviews 2012, Issue 2. Art. No.: CD008225. DoI: 10.1002/14651858.CD008225.pub2.
Long‐distance dispersal in a fire‐ and livestock‐protected savanna
Authors: Tarazi Roberto , Sebbenn Alexandre M. , Kageyama Paulo Y. , Vencovsky Roland 
Published: March 2013

AbstractSavannas are highly diverse and dynamic environments that can shift to forest formations due to protection policies. Long‐distance dispersal may shape the genetic structure of these new closed forest formations. We analyzed eight microsatellite loci using a single‐time approach to understand contemporary pollen and effective seed dispersal of the tropical tree, Copaifera langsdorffii Desf. (Fabaceae), occurring in a Brazilian fire‐ and livestock‐protected savanna. We sampled all adult trees found within a 10.24 ha permanent plot, young trees within a subplot of 1.44 ha and open‐pollinated seeds. We detected a very high level of genetic diversity among the three generations in the studied plot. Parentage analysis revealed high pollen immigration rate (0.64) and a mean contemporary pollen dispersal distance of 74 m. In addition, half‐sib production was 1.8 times higher than full‐sibs in significant higher distances, indicating foraging activity preference for different trees at long distances. There was a significant and negative correlation between diameter at breast height (DBH) of the pollen donor with the number of seeds (r = −0.640, P‐value = 0.032), suggesting that pollen donor trees with a higher DBH produce less seeds. The mean distance of realized seed dispersal (recruitment kernel) was 135 m due to the large home range dispersers (birds and mammals) in the area. The small magnitude of spatial genetic structure found in young trees may be a consequence of overlapping seed shadows and increased tree density. Our results show the positive side of closed canopy expansion, where animal activities regarding pollination and seed dispersal are extremely high.
Influence of hydrogenation and antioxidants on the stability of soybean oil biodiesels
Authors: Alexandrino Cristiane D. , Morais Selene M. , Oliveira Micheline S. C. , Machado Lyeghyna K. A. , Martins Clécio G. , Craveiro Afrânio A. , Rocha Naele C. , Valle Camila P. , Malveira Jackson Q. , Jorge Fernando A. S. 
Published: March 2013

AbstractThis study examined the influence of hydrogenation and antioxidant activity of natural products derived from Mangifera indica on soybean biodiesel stability. Biodiesels were prepared with refined, semi‐refined, and partially hydrogenated soybean oil and the stability was evaluated in a Rancimat apparatus. The biodiesel from partially hydrogenated soybean oil showed greater stability (11.9 h), exceeding the standard limit established by the Brazilian National Petroleum Agency (6 h). Gallic acid, tannic acid, and mango seed kernel extract were evaluated as antioxidants. The gallic acid showed higher antioxidant ability than the other products, increasing twofold the oxidative stability (20.8 h). The results indicate the importance of mango seed as a source of efficient antioxidants for biodiesel just like gallic acid.Practical applications: The results provide detailed information about: (i) the influence of hydrogenation on soybean biodiesel stability; (ii) the antioxidant activity of natural products derived from M. indica; (iii) and the importance of each phenolic constituent on the stability. Mango seed is an abundant waste product from fruit juice industry in Brazil and could be used for obtaining an effective antioxidant additive for biodiesel.
Chiral Aminated α‐Methylenebenzocycloalkenes from o‐Bromoaryl Aldehydes and Ketones
Authors: Sirvent Juan Alberto , Foubelo Francisco , Yus Miguel 
Published: March 2013

AbstractChiral tert‐butylsulfinyl imines 3, which are easily prepared from the corresponding bromo carbonyl compounds 1 and tert‐butanesulfinamide (2), undergo a diastereoselective allylation by using indium metal and allyl bromide to give the corresponding homoallyl sulfinylamines 4. Treatment of compounds 4 with a catalytic amount of palladium acetate and triphenylphosphane gives exo‐methylene‐substitutedsulfinylamino)benzocycloalkenes 5 (five‐ to seven‐membered rings) that are easily deprotected with hydrochloric acid to give chiral primary amines 6.
Sequential Fullerenylation of Bis‐malonates – Efficient Access to Oligoclusters with Different Fullerene Building Blocks
Authors: Wasserthal Lennard K. , Kratzer Andreas , Hirsch Andreas 
Published: March 2013

AbstractA method for the sequential fullerenylation of bis‐malonates with parent C60 and C2v‐symmetric pentakis‐adducts is reported. This approach relies on the finding that (a) chloromalonates can be used for the nucleophilic cyclopropanation of [6,6] double bonds of C60, and (b) chloromalonates, in contrast to bromomalonates, do not undergo base‐catalyzed halogen exchange reactions. For the proof of concept, we synthesized a heptafullerene by using a divergent approach based on a fullerene hexakis‐adduct with six bis‐malonate addends in octahedral positions, each of which is suitable for an additional cyclopropanation of a fullerene building block.
Mechanical Characteristics of Electrolytes Assessed with Resonant Ultrasound Spectroscopy
Authors: Araki W. , Azuma H. , Yota T. , Arai Y. , Malzbender J. 
Published: March 2013

AbstractElastic properties and residual stresses are critical for the assessment of the reliability of ceramics components. The thin electrolyte layer of anode supported SOFCs is under a state of high compressive residual stress. In the present study, the elastic properties of this layer as well as the residual stress distribution induced in the anode‐supported planar SOFC cell were examined by using the resonant ultrasound spectroscopy (RUS). A modal analysis by finite element simulation demonstrated that the RUS has a great potential to determine these mechanical characteristics. The Young's modulus can be determined from the natural frequencies of the layered sample whilst the residual stress can be determined using the sample with a semi‐hole. Estimates of the Poisson's ratio are possible. In the experiment, various individual resonant oscillations were successfully identified using the present RUS system. Hence, by comparison of experimental results and simulations, the elastic properties as well as the residual stress were obtained. Although the proposed method is still experimentally challenging, it could be developed to become a powerful tool to simultaneously determine residual stresses and elastic constants of thin‐layered systems.
Impact of primary biliary cirrhosis on perceived quality of life: The UK-PBC national study
Authors: Mells George F. , Pells Greta , Newton Julia L. , Bathgate Andrew J. , Burroughs Andrew K. , Heneghan Michael A. , Neuberger James M. , Day Darren B. , Ducker Samantha J. , Sandford Richard N. , Alexander Graeme J. , Jones David E.J. 
Published: March 2013

Abstract

Primary biliary cirrhosis (PBC) has a complex clinical phenotype, with debate about the extent and specificity of frequently described systemic symptoms such as fatigue. The aim of this study was to use a national patient cohort of 2,353 patients recruited from all clinical centers in the UK to explore the impact of disease on perceived life quality. Clinical data regarding diagnosis, therapy, and biochemical status were collected and have been reported previously. Detailed symptom phenotyping using recognized and validated symptom assessment tools including the PBC-40 was also undertaken and is reported here. Perception of poor quality of life and impaired health status was common in PBC patients (35% and 46%, respectively) and more common than in an age-matched and sex-matched community control group (6% and 15%, P < 0.0001 for both). Fatigue and symptoms of social dysfunction were associated with impaired perceived quality of life using multivariate analysis. Fatigue was the symptom with the greatest impact. Depression was a significant factor, but appeared to be a manifestation of complex symptom burden rather than a primary event. Fatigue had its greatest impact on perceived quality of life when accompanied by symptoms of social dysfunction, suggesting that maintenance of social networks is critical for minimizing the impact of fatigue. Conclusion: The symptom burden in PBC, which is unrelated to disease severity or ursodeoxycholic acid response, is significant and complex and results in significant quality of life deficit. The complexity of symptom burden, and its lack of relation to disease severity and treatment response, suggest that specific approaches to symptom management are warranted that address both symptom biology and social impact. (Hepatology 2013;58:-)
New horizons in hepatitis C antiviral therapy with direct-acting antivirals
Authors: Aghemo Alessio , De Francesco Raffaele 
Published: March 2013

Abstract

Most direct-acting antivirals (DAAs) that are being developed as therapy against hepatitis C virus target the NS3/4A protease, the NS5A protein, and the NS5B polymerase. The latter enzyme offers different target sites: the catalytic domain for nucleos(t)ide analogues as well as a number of allosteric sites for nonnucleos(t)ide inhibitors. Two NS3/4A protease inhibitors have been approved recently, and more than 40 new NS3/4A, NS5A, or NS5B inhibitors are in development. These agents can achieve very high cure rates when combined with pegylated interferon-β and ribavirin and show promising clinical results when administered in all-oral combinations. In addition to the more canonical drug targets, new alternative viral targets for small-molecule drug development are emerging, such as p7 or NS4B and viral entry. Future research will need to define well-tolerated and cost-effective DAA combinations that provide the highest rates of viral eradication in all patients (including those with advanced liver disease), the broadest spectrum of action on viral genotypes showing minimal or no clinical resistance, and the shortest treatment duration. (Hepatology 2013)