bluuebunny/crossref_metadata_2025_split huggingface dataset:
A novel ERAP2 haplotype structure in a Chilean population: implications for ERAP2 protein expression and preeclampsia risk
Authors: Vanhille Derek L. , Hill Lori D. , Hilliard DaShaunda D. , Lee Eun D. , Teves Maria E. , Srinivas Sindhu , Kusanovic Juan P. , Gomez Ricardo , Stratikos Efstratios , Elovitz Michal A. , Romero Roberto , Strauss Jerome F. 
Published: May 2013

AbstractSingle nucleotide polymorphisms (SNPs) in the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene are associated with preeclampsia (PE) in different populations. rs2549782, a coding variant (N392K) that significantly affects substrate specificity, is in linkage disequilibrium (LD) with rs2248374, a marker SNP associated with ERAP2 protein expression in previously studied populations. As a result of nonsense‐mediated RNA decay, ERAP2 protein is not expressed from the rs2248374 G allele. We previously reported that the fetal rs2549782 minor G allele is associated with PE in African‐Americans, but not in Chileans. In this study, we found that rs2549782 was in LD with rs2248374 in African‐Americans, but not in Chileans. The unexpected lack of strong LD in Chileans raised the possibility that rs2248374 could be associated with PE in the absence of an association with rs2549782. However, we found no significant association for this allele with PE in Chileans. Chileans homozygous for the rs2248374 G allele did not express 110 kDa ERAP2 protein, consistent with nonsense‐mediated RNA decay, and carriers of the rs2248374 A allele did. We conclude that the Chilean ERAP2 haplotype structure allows for the expression of the major T allele of rs2549782 encoding 392N, which could impact peptide trimming and antigen presentation. Our discovery of racial differences in genetic structure and association with PE reveal heretofore unrecognized complexity of the ERAP2 locus.
The effect of chronic thienorphine administration on long‐term potentiation and synaptic structure in rat hippocampus
Authors: Yong Zheng , Yan Lingdi , Dong Zhaoqi , Wang Xiao , Su Ruibin , Gong Zehui 
Published: May 2013

ABSTRACTThienorphine is a new nonselective partial agonist of opioid receptors, which is currently under a Phase II clinical trial in China as a new treatment for opioid dependence. In this study, we compared the effect of thienorphine with morphine on long‐term potentiation (LTP) in the lateral perforant path (LPP)‐granule cell synapse of the rat dentate gyrus (DG). Furthermore, the effect of thienorphine on the synaptic structure of the CA1 hippocampal region and the expression of synaptophysin was investigated. Results indicated interesting differences between thienorphine and morphine on the modulation of hippocampal synaptic plasticity. Chronic thienorphine treatment facilitated LTP in the LPP‐DG cell synapses more than chronic morphine treatment. Morphometric measurement and analysis showed that chronic thienorphine administration decreased the length of the active zone and reduced the thickness of CA1 postsynaptic densities compared with the saline group (control), but were elevated compared with the morphine group. Furthermore, the expression of hippocampal synaptophysin was increased with chronic thienorphine administration but reduced with chronic morphine treatment. Taken together, our study clearly demonstrates that chronic thienorphine treatment enhances LTP, modulates hippocampal synaptic structure, and increases the expression of hippocampal synaptophysin. Therefore, further study is warranted to investigate thienorphine as a new treatment for opioid dependence. Synapse 67:779–785, 2013. © 2013 Wiley Periodicals, Inc.
Higher pretreatment 5‐HT1A receptor binding potential in bipolar disorder depression is associated with treatment remission: A naturalistic treatment pilot PET study
Authors: Lan Martin J. , Hesselgrave Natalie , Ciarleglio Adam , Ogden R. Todd , Sullivan Gregory M. , Mann J. John , Parsey Ramin V. 
Published: May 2013

ABSTRACTBipolar disorder is a major cause of disability and a high risk for suicide. The pathophysiology of the disorder remains largely unknown. Medication choice for bipolar depression patients involves trial and error. Our group reported previously that brain serotonin 1A (5‐HT1A) receptor binding measured by positron emission tomography (PET) is higher in bipolar depression. We now investigated whether pretreatment 5‐HT1A levels correlates with antidepressant medication outcome. Forty‐one medication‐free DSM‐IV diagnosed, bipolar patients in a major depressive episode had brain PET scans performed using [11C]WAY‐100635 and a metabolite corrected arterial input function. The patients then received naturalistic psychopharmacologic treatment as outpatients and a follow up Hamilton Depression Rating Scale (HDRS) after 3 months of treatment. Patients with 24 item HDRS scores less than 10 were considered to have remitted. A linear mixed effects model was used to compare BPF (binding potential, proportional to the total number of available receptors) in 13 brain regions of interest between remitters and nonremitters. Thirty‐four patients completed 3 months of treatment and ratings; 9 had remitted. Remitters and nonremitters did not differ in age, sex, or recent medication history with serotonergic medications. Remitters had higher [11C]WAY‐100635 BPF across all brain regions compared with nonremitters (P = 0.02). Higher pretreatment brain 5‐HT1A receptor binding was associated with remission after 3 months of pharmacological treatment in bipolar depression. Prospective treatment studies are warranted to determine whether this test predicts outcome of specific types of treatment. Synapse 67:773–778, 2013. © 2013 Wiley Periodicals, Inc.
Roles of Genetic Counselors in South Africa
Authors: Kromberg Jennifer G. R. , Wessels Tina‐Marié , Krause Amanda 
Published: May 2013

AbstractGenetic counseling is a growing health profession in South Africa. Training (set up in 1988) and registration are in place, but job creation remains challenging. The aim of the present study was to investigate the roles played by genetic counselors in the provision of genetic services, in South Africa. A questionnaire comprising items on the types of roles they performed was constructed and counselors were asked to make the log‐books, in which they recorded their daily counseling activities, available. A check list was drawn up so that relevant information could be collected systematically from these log‐books. Then departmental statistics were accessed from the two universities providing genetic services and genetic counselor training. Structured interviews were conducted with the genetic counselors (16 of 23 participated), and data were collected from their completed questionnaires, log‐books and the departmental statistics, for the years 2007 and 2008. These data were analyzed and the findings showed that the counselors counseled about one third (39 %) of all the cases seen at genetic clinics per annum, and the total numbers were increasing. They counseled for 57 different genetic disorders, and their clients represented the range of local ethnic groups. They also had educational, research, marketing and administrative roles. They expected to expand these roles and advance the profession in future. Genetic counselors are versatile, playing several significant roles. As these become better recognized, demand for their services should increase, jobs should be created and the service expanded.
Parkinsonism and distinct dementia patterns in a family with the MAPT R406W mutation
Authors: Carney Regina M. , Kohli Martin A. , Kunkle Brian W. , Naj Adam C. , Gilbert John R. , Züchner Stephan , Pericak‐Vance Margaret A. 
Published: May 2013

AbstractBackgroundThe Arg406Trp (R406W) missense mutation in the microtubule‐associated protein‐tau gene (MAPT) is a known cause of early‐onset dementia. Various dementia phenotypes have been described, including frontotemporal dementia (FTD), FTD with parkinsonism, and early‐onset Alzheimer disease (EOAD)‐like presentations.MethodsUsing whole‐exome capture with subsequent sequencing, we identified the R406W mutation in a family with multiple individuals with clinically diagnosed EOAD, in a pattern suggesting autosomal dominant inheritance. We reevaluated all available family members clinically.ResultsEach of the affected individuals had a course meeting clinical criteria for EOAD. Two distinct disease trajectories were apparent: one rapidly progressive, and the other long and gradual. Four of five affected individuals also manifested parkinsonian symptoms. FTD features were not prominent and, when present, appeared only late in the course of dementia.ConclusionsThe MAPT R406W mutation is associated with EOAD‐like symptoms and parkinsonism without FTD, as well as distinct cognitive courses.
An Emergency Department Nurse-Driven Ultrasound-Guided Peripheral Intravenous Line Program
Authors: Moore Cindi 
Published: May 2013

Background: Ultrasound-guided peripheral intravenous (USGPIV) technology is being utilized more frequently in emergency department settings. Traditionally, physicians have performed this procedure to gain vascular access in patients for whom standard intravenous line procedures are unsuccessful. Nurses at Wexner Medical Center at The Ohio State University have shown that a nurse-driven ultrasound program can be successfully implemented in an emergency department. Methods: Standardized training for registered nurses includes a 4-hour didactic and hands-on course and 24 hours of 1-on-1 individualized instruction with a nurse champion. Emphasis is placed on avoiding the larger upper arm veins. Results: A peripheral intravenous line database has been maintained since the beginning of the program in 2009. This database shows a significant percentage of admitted patients received USGPIV service. In 2010, USGPIVs were successfully placed 90% to 98% of the time. Conclusions: Utilizing UGSPIV can expedite treatment and disposition in an emergency department. Ultimately, throughput and wait time for an emergency department bed can thus be similarly affected, positively affecting customer service.
Edge states for the turbulence transition in the asymptotic suction boundary layer
Authors: Kreilos Tobias , Veble Gregor , Schneider Tobias M. , Eckhardt Bruno 
Published: May 2013

AbstractWe demonstrate the existence of an exact invariant solution to the Navier–Stokes equations for the asymptotic suction boundary layer. The identified periodic orbit with a very long period of several thousand advective time units is found as a local dynamical attractor embedded in the stability boundary between laminar and turbulent dynamics. Its dynamics captures both the interplay of downstream-oriented vortex pairs and streaks observed in numerous shear flows as well as the energetic bursting that is characteristic for boundary layers. By embedding the flow into a family of flows that interpolates between plane Couette flow and the boundary layer, we demonstrate that the periodic orbit emerges in a saddle–node infinite-period (SNIPER) bifurcation of two symmetry-related travelling-wave solutions of plane Couette flow. Physically, the long period is due to a slow streak instability, which leads to a violent breakup of a streak associated with the bursting and the reformation of the streak at a different spanwise location. We show that the orbit is structurally stable when varying both the Reynolds number and the domain size.
Survival of the 8.5 mm osseointegrated abutment, and its utility in the obese patient
Authors: Darley M D , Mikulec A A 
Published: May 2013

AbstractBackground:Most of the literature regarding osseointegrated implantation for hearing rehabilitation focuses on the 5.5 mm abutment. This study aimed to add to the data available on the survival of the 8.5 mm abutment, and to describe its utility in obese patients.Objective:To review the outcomes of patients who received a bone-anchored hearing aid implant, and create a model comparing the mechanical forces acting upon combinations of fixture and abutment lengths.Methods:Retrospective chart review and mathematical modelling.Results:In this retrospective cohort study comprising 25 patients, less abutment overgrowth was observed in the 8.5 mm abutment recipients versus recipients of the 5.5 mm abutment. When the principle of equilibrium of a rigid body was applied, the 8.5 mm abutment was at a calculated mechanical disadvantage compared with the 5.5 mm abutment.Conclusion:The 8.5 mm abutment may be useful in patients with copious subcutaneous soft tissue as in the obese population. The 8.5 mm abutment has a calculated mechanical disadvantage, potentially putting the implant under greater mechanical stress; however, the clinical relevance of this is unclear.
Evaluation of interfraction patient setup errors for image-guided prostate and head-and-neck radiotherapy using kilovoltage cone beam and megavoltage fan beam computed tomography
Authors: Qi X. Sharon , Wu Sutan , Newman Francis , Li X. Allen , Hu Angie Y. 
Published: May 2013

AbstractPurposeTo analyse interfraction setup using two different image guidance modalities for prostate and head-and-neck (H&N) cancer treatment.Materials and methodsSeventy-two prostate and 60 H&N cancer patients, imaged with kilovoltage cone beam computed tomography (KVCBCT) or megavoltage fan beam computed tomography (MVFBCT), were studied retrospectively. The daily displacements in mediolateral (ML), craniocaudal (CC) and anteroposterior (AP) dimensions were investigated. The setup errors were calculated to determine the clinical target volume to planning target volume (CTV-to-PTV) margins.ResultsBased on 1,606 KVCBCT and 2,054 MVFBCT scans, average interfraction shifts in ML, CC and AP direction for H&N cases were 0·5 ± 1·5, −0·3 ± 2·0, 0·3 ± 1·7 mm using KVCBCT, 0·2 ± 1·9, −0·2 ± 2·4 and 0·0 ± 1·7 mm using MVFBCT. For prostate cases, average interfraction displacements were −0·3 ± 3·9, 0·2 ± 2·4, 0·4 ± 3·8 mm for MVFBCT and −0·2 ± 2·7, −0·6 ± 2·9, −0·5 ± 3·4 mm for KVCBCT. The calculated CTV-to-PTV margins, if determined by image-guided radiotherapy (IGRT) data, were 5·6 mm (H&N) and 7·8 mm (prostate) for MVFBCT, compared with 4·8 mm and 7·2 mm for KVCBCT. We observed no statistically significant difference in daily repositioning using KVCBCT and MVFBCT in early, middle and late stages of the treatment course.ConclusionIn the absence of IGRT, the CTV-to-PTV margin determined using IGRT data, may be varied for different imaging modalities for prostate and H&N irradiation.
Japanische Hofmusik gagaku und Musiktherapie
Authors: Fujita Rinko 
Published: May 2013

Im folgenden Beitrag wird die Auswirkung der japanischen Musikform gagaku auf die Musiktherapie untersucht. Dabei wird ein allgemeiner Überblick sowohl über die musikalischen Eigenschaften als auch über die kulturhistorischen und soziokulturellen Kontexte gegeben. Aus diesen Funktionen geht die starke Verbindung von gagaku mit religiösem Ritus und Zeremoniell hervor. Religiöse Ansichten basieren in Japan vornehmlich auf altüberlieferten Glaubensvorstellungen und die Verehrung von schintoistischen Gottheiten. Durch das Entwickeln eines eigenen Therapieansatzes unter Verwendung wichtiger musikalischer Elemente der gagaku stellt sich heraus, dass die japanische Hofmusik sowohl durch ihre soziokulturelle Assoziation als auch durch ihre musikalischen, strukturellen und akustischen Eigenschaften therapeutisches Potential in sich birgt und Ansätze für die aktive und rezeptive Therapie bereithält. Gleichzeitig werden aber einige Probleme des Ansatzes wie der kulturspezifische Ausdruck von Emotion oder die Verfremdung der „eigenen” Musik benannt, die erst über eine längere Zeitspanne hinweg gelöst werden können. Davon abgesehen aber öffnen die Musik und die Tänze der gagaku ein weites Feld an Möglichkeiten und eine innovative und zugleich traditionelle therapeutische Herangehensweise.
COPRED: prediction of fold, GO molecular function and functional residues at the domain level
Authors: López Daniel , Pazos Florencio 
Published: May 2013

Abstract
Summary: Only recently the first resources devoted to the functional annotation of proteins at the domain level started to appear. The next step is to develop specific methodologies for predicting function at the domain level based on these resources, and to implement them in web servers to be used by the community. In this work, we present COPRED, a web server for the concomitant prediction of fold, molecular function and functional sites at the domain level, based on a methodology for domain molecular function prediction and a resource of domain functional annotations previously developed and benchmarked.
Availability and implementation: COPRED can be freely accessed at http://csbg.cnb.csic.es/copred. The interface works in all standard web browsers. WebGL (natively supported by most browsers) is required for the in-line preview and manipulation of protein 3D structures. The website includes a detailed help section and usage examples.
Contact: pazos@cnb.csic.es
Drug–target interaction prediction through domain-tuned network-based inference
Authors: Alaimo Salvatore , Pulvirenti Alfredo , Giugno Rosalba , Ferro Alfredo 
Published: May 2013

Abstract
Motivation: The identification of drug–target interaction (DTI) represents a costly and time-consuming step in drug discovery and design. Computational methods capable of predicting reliable DTI play an important role in the field. Recently, recommendation methods relying on network-based inference (NBI) have been proposed. However, such approaches implement naive topology-based inference and do not take into account important features within the drug–target domain.
Results: In this article, we present a new NBI method, called domain tuned-hybrid (DT-Hybrid), which extends a well-established recommendation technique by domain-based knowledge including drug and target similarity. DT-Hybrid has been extensively tested using the last version of an experimentally validated DTI database obtained from DrugBank. Comparison with other recently proposed NBI methods clearly shows that DT-Hybrid is capable of predicting more reliable DTIs.
Availability: DT-Hybrid has been developed in R and it is available, along with all the results on the predictions, through an R package at the following URL: http://sites.google.com/site/ehybridalgo/.
Contact: apulvirenti@dmi.unict.it
Supplementary information: Supplementary data are available at Bioinformatics online.
Sinus Headache
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Migraine and other primary headache types are often misdiagnosed as “sinus headache” because of location and nasal symptoms. However, there are some rhinological and sinus conditions that do lead to head and facial pain. Sphenoid sinus inflammation is particularly likely to produce headache. The causes and ways of diagnosing of headache due to rhinosinusitis and related conditions are discussed in this chapter.
Vasculitis Headache
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Inflammation of cerebral arteries is virtually always painful. Both primary and secondary forms (including drug-induced cerebral arteritis) may present primarily with headache and must be excluded. This chapter outlines diagnostic and treatment considerations in cerebral vasculitis. The curious disorders “headache with associated neurological deficits and cerebrospinal fluid lymphocytosis” and “reversible cerebral vasoconstriction syndrome” share some features of cerebral vasculitis and are also discussed in this chapter.
Nummular Headache
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Nummular (“coin-like” ) headache pain refers to a localized area of scalp pain and is thought to be due to a local neuropathic process, akin to trigeminal or cervical root branch neuralgia. Diagnosis and treatment options (including local anesthetic procedures) are discussed in this chapter.
Menstrual Headaches
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Headaches occurring around the time of menses tend to be very disabling. Most headaches associated with menses are migraines without aura. Fortunately, there are a number of good treatment strategies, both for acute pain relief as well as for prophylaxis which can be limited to several days surrounding the onset of menses (“miniprophylaxis” ). This chapter discusses the identification and clinical management of menstrually related headaches.
Analgesic Overuse
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Patients with medication overuse headache (MOH) must overcome their dependence on acute medications in order for improvement to occur. Most patients with MOH can be treated on an outpatient basis. This chapter reviews strategies for treating patients with MOH due to simple analgesics, combination medications, butalbital-containing compounds, and opioids.
Pseudotumor
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Pseudotumor cerebri, or idiopathic intracranial hypertension, often affects young obese women. Hallmarks are headaches of various types, papilledema, and increased opening pressure on lumbar puncture. When headaches or visual dysfunction fail to respond to acetazolamide, there are several other alternatives, which are explained in this chapter.
Posttraumatic Headaches
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
One of the more controversial areas in headache medicine is the diagnosis and prognosis of trauma-related headache. Either mild or severe head and/or neck trauma can lead to chronic headaches, which are also associated with the broader postconcussive syndrome. These conditions, along with their prognostic and legal ramifications, are discussed.
Transient Global Amnesia and Migraine
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
Transient global amnesia (TGA) is a well-recognized neurological syndrome resulting in a short-lasting inability to create new memory. The pathophysiology of the disorder is not known, but it has been linked to migraine, transient ischemic attack, and perhaps epilepsy. This chapter reviews the work-up needed prior to prescribing triptans in migraine sufferers who have had TGA or other transient neurological events.
Migraine and Patent Foramen Ovale
Authors: Newman Lawrence C. , Levin Morris 
Published: May 2013

Abstract
The observation of the significantly increased incidence of patent foramen ovale (PFO) in migraine sufferers has raised questions about causality and the potential benefit of PFO repair in otherwise asymptomatic patients. This chapter addresses the nature of the relationship between migraine and PFO as well as the pros and cons for transcatheter PFO repair in migraine patients.
Lymphoma
Authors: Hoskin Peter , Fowler Charlotte 
Published: May 2013

Abstract
Chapter 5 discusses lymphoma, which covers a broad spectrum of disease entities that is reflected in a wide range of imaging involved in its diagnosis and management. Whilst the pathological subtypes are of considerable importance in disease management, they do not greatly influence the staging processes in which imaging is used, although the two main groups, Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) have very different patterns of disease distribution which can influence imaging strategies.
Rectal cancer
Authors: Goh Vicky , Glynne-Jones Rob 
Published: May 2013

Abstract
Chapter 11 covers rectal cancer, and presentation includes rectal bleeding, change in bowel habit, frequency of defecation, tenesmus, rectal fullness, and pelvic pain. Distant spread occurs to the liver, lung, retroperitoneum, ovary, and peritoneal cavity. Advances in surgical technique and more accurate radiotherapy planning and delivery have improved rectal cancer treatment in the past two decades. Anterior resection combined with total mesorectal excision (TME) has become the standard surgical procedure, facilitating the radial clearance of the primary tumour, mesorectal tissue, and associated vascular, lymphatic, and perineural deposits, thus improving local recurrence rates.