bluuebunny/crossref_metadata_2025_split huggingface dataset:
Simultaneous bilateral video-assisted thoracic surgery is safe and feasible for multiple primary lung cancers
Authors: Yang Libing , Guo Chao , Zhang Ye , Jiang Huizhen , Ma Lian , Liu Hongsheng , Li Shanqing 
Published: July 2024

Abstract
Background
The treatment for bilateral synchronous multiple primary lung cancers (MPLC) remains challenging. Simultaneous bilateral video-assisted thoracic surgery (VATS) may be an optimal treatment with curative intent, but its safety and feasibility are controversial.

Methods
One hundred and fifty-eight patients who underwent simultaneous bilateral VATS (simultaneous group) and 79 who underwent two-staged bilateral VATS (two-staged group) were included in this study. Their medical records were retrospectively reviewed and analyzed.

Results
The majority of patients were female and non-smokers. The most common surgical plan was lobectomy and contralateral wedge resection in both groups. There was no significant difference in the postoperative complication rate between the simultaneous groups and two-staged group (13.3% vs. 11.4%, p = 0.73). Patients who underwent simultaneous bilateral resection had shorter hospital stays, shorter anesthesia time and less chest drainage compared with those who underwent two-staged resection. Advanced TNM stage, complicated surgical plan and aggressive lymph node resection were risk factors for postoperative complications in simultaneous bilateral VATS. Patients in two groups had similar overall survival and disease free survival (p = 0.2).

Conclusions
Simultaneous bilateral VATS for bilateral lung nodule resection is as safe and feasible as two-staged bilateral VATS. Patients who underwent simultaneous bilateral resection had similar or even better outcomes compared to that of the two-staged group. Simultaneous bilateral VATS is potentially an optimal treatment option for patients with erarly cTNM stage and good physical condition.
The impact of Paclitaxel-based hyperthermic intraperitoneal chemotherapy in advanced high-grade serous ovarian cancer patients - interim analysis of safety and immediate efficacy of a randomized control trial (C-HOC trial)
Authors: Wang Qun , Liu Hua , Shen Yuhong , Shen Lifei , Li Jian , Feng Weiwei 
Published: July 2024

Abstract
Objective
This study evaluates the potential superiority of combining paclitaxel-based hyperthermic intraperitoneal chemotherapy (HIPEC) with sequential intravenous neoadjuvant chemotherapy over intravenous neoadjuvant chemotherapy alone in Chinese patients with Federation of Gynecology and Obstetrics (FIGO) stage IIIC, IVA and IVB high-grade serous ovarian/fallopian tube carcinoma (HGSOC). This interim analysis focuses on the safety and immediate efficacy of both regimens to determine the feasibility of the planned trial (C-HOC Trial).

Methods
In a single-center, open-label, randomized control trial, FIGO stage IIIC, IVA, and IVB HGSOC patients (FAGOTTI score ≥ 8 during laparoscopic exploration) unsuitable for optimal cytoreduction in primary debulking surgery (PDS) were randomized 2:1 during laparoscopic exploration. The Experiment Group (HIPEC Group) received one cycle of intraperitoneal neoadjuvant laparoscopic hyperthermic intraperitoneal chemotherapy (paclitaxel) followed by three cycles of intravenous chemotherapy (paclitaxel plus carboplatin), while the Control Group received only three cycles of intravenous chemotherapy. Both groups subsequently underwent interval debulking surgery (IDS). The adverse effects of chemotherapy, postoperative complications, and pathological chemotherapy response scores (CRS) after IDS were compared.

Results
Among 65 enrolled patients, 39 HIPEC Group and 21 Control Group patients underwent IDS. Grade 3–4 chemotherapy-related adverse effects were primarily hematological with no significant differences between the two groups. The HIPEC Group exhibited a higher proportion of CRS 3 (20.5% vs. 4.8%; P = 0.000). R0 resection rates in IDS were 69.2% (HIPEC Group) and 66.7% (Control Group). R2 resection occurred in 2.6% (HIPEC Group) and 14.3% (Control Group) cases. No reoperations or postoperative deaths were reported, and complications were managed conservatively.

Conclusions
Combining HIPEC with IV NACT in treating ovarian cancer demonstrated safety and feasibility, with no increased chemotherapy-related adverse effects or postoperative complications. HIPEC improved tumor response to neoadjuvant chemotherapy, potentially enhancing progression-free survival (PFS). However, the final overall survival results are pending, determining if HIPEC combined with IV NACT is superior to IV NACT alone.
Experimental Study on Properties of Graphene and Hollow Glass Powder-Added Ultra-High Strength Concrete
Authors: Park Young-Jun , Lee Hong-Sung , Seo Tae-Seok 
Published: July 2024

AbstractA new ultra-high strength concrete, in which oxidized graphene nanoplatelet (GO) and hollow glass powder (HGP) are added, has been developed by authors. This paper presents the material properties of the concrete such as workability, compressive and tensile strengths, internal micro structure (SEM and MIP) as well as air-tightness which was tested using an equipment developed in this study. Test results show that workability and tensile strength significantly increase by a small addition of HGP, and that cGO (GO product of company c) and HGP are well dispersed without agglomeration effect, resulting in more than 20% of reduction in porosity. It is also observed that air-tightness increases by 40% compared with conventional ultra-high strength concrete due to reduction in porosity; thus, new ultra-high strength concrete is anticipated to be effectively used for structures that requires air-tightness such as hyperloop tube. Consequently, it was observed that the workability and mechanical properties of UHSC were increased when cGO and HGP were used instead of silica fume (SF), and authors believe that utilization of new material would contribute to the change in manufacturing method and increase in mechanical properties of concrete.
Evaluation of surface response of SiC and fly ash-filled Prosopis juliflora fibre-reinforced epoxy composites under dry sliding wear conditions using Taguchi method
Authors: Thirupathi Suresh , Solai Ayyappan , Pitchumani Shenbaga Velu , Gopalan Venkatachalam , Mallichetty Elango 
Published: July 2024

AbstractProsopis juliflora (PJ) fibre-reinforced polymer composites are fabricated with fly ash and SiC as fillers with different weight percentages. Jute layers are also sandwiched for added strength in the structure. The wear behaviour is found for the prepared composition of samples. Pin-on-disc wear testing apparatus is used for the wear performance along with the design of experiments approach using orthogonal arrays of Taguchi’s. The effect of the input parameters (load, sliding velocity, speed) is studied on wear resistance. The experimental design creates sliding wear evaluations based on Taguchi’s L9 orthogonal array to identify the most dominating factors influencing the wear rate. This study demonstrates that the most important component affecting the sliding wear rate of the composite materials is followed by the sliding velocity, speed, and load. The result of the wear rate decreases with an increase in filler content and also increases with sliding velocity. The samples with fly ash and SiC fillers reportedly seemed to have the best wear rates.
Clinical Validation of Mathematically Derived Early Tumor Dynamics for Solid Tumors in Response to Durvalumab
Authors: Li Qin , Cristini Vittorio , Gupta Ashok , Achour Ikbel , Barrett J. Carl , Koay Eugene J. 
Published: July 2024

PURPOSE Early prediction of response to immunotherapy may help guide patient management by identifying resistance to treatment and allowing adaptation of therapies. This analysis evaluated a mathematical model of response to immunotherapy that provides patient-specific prediction of outcome using the initial change in tumor size/burden from baseline to the first follow-up visit on standard imaging scans. METHODS We applied the model to 600 patients with advanced solid tumors who received durvalumab in Study 1108, a phase I/II trial, and compared outcome prediction performance versus size-based criteria with RECIST version 1.1 best overall response (BOR), baseline circulating tumor (ct)DNA level, and other clinical/pathologic predictors of immunotherapy response. RESULTS In multiple solid tumors, the mathematical parameter representing net tumor growth rate at the first on-treatment computed tomography (CT) scan assessed around 6 weeks after starting durvalumab ( α1) had a concordance index to predict overall survival (OS) of 0.66-0.77 on multivariate analyses. This measurement of early tumor dynamics significantly improved multivariate OS models that included standard RECIST v1.1 criteria, baseline ctDNA levels, and other clinical/pathologic factors in predicting OS. Furthermore, α1 was assessed consistently at the first on-treatment CT scan, whereas all traditional RECIST BOR groups were confirmed only after this time. CONCLUSION These results support further exploring α1 as an integral biomarker of response to immunotherapy. This biomarker may be predictive of further benefit and can be assessed before RECIST response groups can be assigned, potentially providing an opportunity to personalize oncologic management.
Navigated Intraoperative Ultrasound Offers Effective and Efficient Real-Time Analysis of Intracranial Tumor Resection and Brain Shift
Authors: West Timothy R. , Mazurek Mercy H. , Perez Nicole A. , Razak Shahaan S. , Gal Zsombor T. , McHugh Jeffrey M. , Choi Bryan D. , Nahed Brian V. 
Published: July 2024

BACKGROUND AND OBJECTIVES:
Neuronavigation is a fundamental tool in the resection of intracranial tumors. However, it is limited by its calibration to preoperative neuroimaging, which loses accuracy intraoperatively after brain shift. Therefore, surgeons rely on anatomic landmarks or tools like intraoperative MRI to assess the extent of tumor resection (EOR) and update neuronavigation. Recent studies demonstrate that intraoperative ultrasound (iUS) provides point-of-care imaging without the cost or resource utilization of an intraoperative MRI, and advances in neuronavigation-guided iUS provide an opportunity for real-time imaging overlaid with neuronavigation to account for brain shift. We assessed the feasibility, efficacy, and benefits of navigated iUS to assess the EOR and restore stereotactic accuracy in neuronavigation after brain shift.

METHODS:
This prospective single-center study included patients presenting with intracranial tumors (gliomas, metastasis) to an academic medical center. Navigated iUS images were acquired preresection, midresection, and postresection. The EOR was determined by the surgeon intraoperatively and compared with the postoperative MRI report by an independent neuroradiologist. Outcome measures included time to perform the iUS sweep, time to process ultrasound images, and EOR predicted by the surgeon intraoperatively compared with the postoperative MRI.

RESULTS:
This study included 40 patients consisting of gliomas (n = 18 high-grade gliomas, n = 4 low-grade gliomas, n = 4 recurrent) and metastasis (n = 18). Navigated ultrasound sweeps were performed in all patients (n = 83) with a median time to perform of 5.5 seconds and a median image processing time of 29.9 seconds. There was 95% concordance between the surgeon's and neuroradiologist's determination of EOR using navigated iUS and postoperative MRI, respectively. The sensitivity was 100%, and the specificity was 94%.

CONCLUSION:
Navigated iUS was successfully used for EOR determination in glioma and metastasis resection. Incorporating navigated iUS into the surgical workflow is safe and efficient and provides a real-time assessment of EOR while accounting for brain shift in intracranial tumor surgeries.
Order Independence in Sequential, Issue-by-Issue Voting
Authors: Gershkov Alex , Moldovanu Benny , Shi Xianwen 
Published: July 2024

We study when the voting outcome is independent of the order of issues put up for vote in a spatial multidimensional voting model. Agents equipped with norm-based preferences that use a norm to measure the distance from their ideal policy vote sequentially and issue by issue via simple majority. If the underlying norm is generated by an inner product—such as the Euclidean norm—then the voting outcome is order independent if and only if the issues are orthogonal. If the underlying norm is a general one, then the outcome is order independent if the basis defining the issues to be voted upon satisfies the following property; for any vector in the basis, any linear combination of the other vectors is Birkhoff–James orthogonal to it. We prove a partial converse in the case of two dimensions; if the underlying basis fails this property, then the voting order matters. Finally, despite existence results for the two-dimensional case and for the general lp case, we show that nonexistence of bases with this property is generic. Funding: The research of A. Gershkov is supported by the Israel Science Foundation [Grant 1118/22]. The research of B. Moldovanu is supported by the German Science Foundation through the Hausdorff Center for Mathematics and The Collaborative Research Center Transregio 224. The research of X. Shi is supported by the Social Sciences and Humanities Research Council of Canada.
who’s tired of michel foucault? une étude sur les perspectives foucaldiennes pour penser l’articulation de la production de l’enfance et des rapports de colonialité
Authors: Roland Elsa , Iacobino Serena 
Published: July 2024

Cet article prend pour point de départ les généalogies de l’enfance de Michel Foucault disséminées dans son œuvre et complexifiées par les études foucaldiennes contemporaines, en particulier les recherches féministes de Silvia Federici (et ses généalogies des femmes) et les études postcoloniales d’Ann Laura Stoler (et ses généalogies des colonisés). Foucault passant sous silences l’histoire des femmes et des colonies, ce détour par des généalogies féministes et postcoloniales nous permettra de nous inscrire dans les débats sur l’intersectionnalité. En effet, depuis les années 1990, cette perspective méthodologique a été pensée de multiples manières (comme articulation, matrice, assemblage etc.), il s’agira donc de voir comment penser l’intersectionnalité en référence aux cadres d’analyse foucaldiens et à leurs critiques. Plus précisément, en réunissant ces auteurs et leurs généalogies, cet article tentera de se situer dans les débats contemporains sur l’intersection du Childism et du mouvement décolonial. Alors que certains auteurs considèrent que la production de l’enfance/de l’âge précède la production de la colonialité/de la race, d’autres voient le contraire. Pour entrer dans ces débats, nous reprendrons à Bacchetta (2015) l’idée de co-formations et de co-productions des rapports coloniaux et âgistes dans l’histoire longue des métropoles et des colonies. Ce faisant, nous tenterons de décrire et d’analyser les relations d’assujettissement (de genre, de classe, de race ou d’âge) d’une part, comme un effet de multiplicité selon des conjonctures spécifiques, et d’autre part, comme la cristallisation de relations de pouvoir qui s’étendent sur de larges espace-temps.
Analyze interleukin-1β, interleukin-6, and tumor necrosis factor-α levels in dry eye and the therapeutic effect of cyclosporine A
Authors: Wu Juan , Li Gui-Jun , Niu Jie , Wen Fei , Han Li 
Published: July 2024

BACKGROUND
Dry eye is a common eye disease. Artificial tears supplements are widely used for the treatment of dry eyes. However, multiple adverse effects have been observed in patients receiving long-term treatment with artificial tears, which may affect the therapeutic effect.
AIM
To analyze the characteristics of interleukin-1β (IL-1β), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-α) levels in patients with dry eye and the therapeutic effect of artificial tears combined with cyclosporine A.
METHODS
A total of 124 dry eye patients treated at The First People’s Hospital of Xining from April 2020 to April 2022 were selected as the observation group, while 20 healthy individuals served as the control group during the same period. Levels of inflammatory markers, including IL-1β, IL-6, and TNF-α, were analyzed. The observation group was further divided into a study group and a control group, each consisting of 62 patients. The control group received artificial tears, whereas the study group received a combination of artificial tears and cyclosporine A. Inflammatory markers, Schirmer’s test (SIT), tear break-up time (TBUT), corneal fluorescein staining (CFS), National Eye Institute Visual Function Questionnaire-25 (NEI-VFQ-25) scores, and adverse events (AEs) were compared between the two groups.
RESULTS
The observation group exhibited significantly elevated serum levels of IL-1β, IL-6, and TNF-α in comparison to the healthy group. Following treatment, the study group demonstrated substantial reductions in IL-1β, IL-6, and TNF-α levels relative to the control group. Moreover, after treatment, the study group experienced a marked decrease in CFS scores and significant increases in both SIT and BUT levels when compared to the control group. Additionally, significant improvements were observed in the primary symptom of dry eye and secondary symptoms such as photophobia, foreign body sensation, fatigue, red eye, and burning sensation within the study group. Furthermore, post-treatment NEI-VFQ-25 scores across all dimensions exhibited significant enhancements in the study group compared to the control group (P < 0.05). It is noteworthy that significant AEs were reported in both groups throughout the treatment period.
CONCLUSION
Cyclosporine A combined with artificial tears is effective in treating dry eye, yielding enhanced outcomes by improving SIT and TBUT levels, reducing CFS scores, and ameliorating vision-related quality of life.
Clinical study on improving the diagnostic accuracy of adult elbow joint cartilage injury by multisequence magnetic resonance imaging
Authors: Ding Wei-Wei , Ding Lei , Li Li , Zhang Pan , Gong Rui , Li Jian , Xu Meng-Ying , Ding Feng , Chen Bing 
Published: July 2024

BACKGROUND
Due to frequent and high-risk sports activities, the elbow joint is susceptible to injury, especially to cartilage tissue, which can cause pain, limited movement and even loss of joint function.
AIM
To evaluate magnetic resonance imaging (MRI) multisequence imaging for improving the diagnostic accuracy of adult elbow cartilage injury.
METHODS
A total of 60 patients diagnosed with elbow cartilage injury in our hospital from January 2020 to December 2021 were enrolled in this retrospective study. We analyzed the accuracy of conventional MRI sequences (T1-weighted imaging, T2-weighted imaging, proton density weighted imaging, and T2 star weighted image) and Three-Dimensional Coronary Imaging by Spiral Scanning (3D-CISS) in the diagnosis of elbow cartilage injury. Arthroscopy was used as the gold standard to evaluate the diagnostic effect of single and combination sequences in different injury degrees and the consistency with arthroscopy.
RESULTS
The diagnostic accuracy of 3D-CISS sequence was 89.34% ± 4.98%, the sensitivity was 90%, and the specificity was 88.33%, which showed the best performance among all sequences (P < 0.05). The combined application of the whole sequence had the highest accuracy in all sequence combinations, the accuracy of mild injury was 91.30%, the accuracy of moderate injury was 96.15%, and the accuracy of severe injury was 93.33% (P < 0.05). Compared with arthroscopy, the combination of all MRI sequences had the highest consistency of 91.67%, and the kappa value reached 0.890 (P < 0.001).
CONCLUSION
Combination of 3D-CISS and each sequence had significant advantages in improving MRI diagnostic accuracy of elbow cartilage injuries in adults. Multisequence MRI is recommended to ensure the best diagnosis and treatment.
Differential expression of plasma cytokines in sepsis patients and their clinical implications
Authors: Liu Hui-Xiu , Wang Yu-Ying , Yang Xue-Feng 
Published: July 2024

BACKGROUND
Sepsis, which is characterized by acute systemic inflammation and is associated with high rates of morbidity and mortality, presents a significant challenge in health care. Some scholars have found that the sequential organ failure assessment (SOFA) and quick SOFA scores are not ideal for predicting severe sepsis and mortality. Microbial culture takes a long time (2-3 d) and provides no information for early diagnosis and treatment. Therefore, new diagnostic methods for sepsis need to be explored.
AIM
To assess cytokine levels in the plasma of sepsis patients and identify potential biomarkers for diagnosing sepsis.
METHODS
Ten sepsis patients admitted to the emergency department within 24 h of onset were enrolled as the observation group, whereas ten noninfected patients served as the control group. Of the 10 noninfected patients, 9 hypertension combined with cerebral infarction, 1 patients with vertiginous syndrome. Plasma Cytokines were measured using the Bio-Plex Pro™ Human Chemokine Panel 40-plex. Differentially expressed cytokines in plasma of sepsis and nonsepsis patients were analyzed using Gene Ontology (GO) functional enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analyses.
RESULTS
Interleukin (IL)-16, granulocyte-macrophage granulocyte-macrophage colony-stimulating factor (GM-CSF), CX3CL1, CXCL9, CXCL16, CCL25, and CCL23 plasma levels were significantly increased in sepsis patients. GO analysis revealed that these cytokines were mainly associated with cellular structures such as intermediates, nuclear plaques, adhesion plaques, lateral plasma membranes, and cell matrix junctions. These genes were involved in various molecular functions, such as cytokine activity, receptor ligand activity, and signal receptor activator activity, contributing to various biological functions, such as leukocyte chemotaxis, migration, and chemotaxis. KEGG analysis indicated involvement in cytokine cytokine receptor interactions, chemokine signaling pathways, virus–protein interactions with cytokines and cytokine receptors, and the tumor necrosis factor signaling pathway.
CONCLUSION
Elevated serum levels of IL-16, GM-CSF, CX3CL1, CXCL9, CXCL16, CCL25, and CCL23 in sepsis patients suggest their potential as diagnostic biomarkers for sepsis.