bluuebunny/crossref_metadata_2025_split huggingface dataset:
Linking a research register to clinical records in older adults’ mental health services: a mixed-methods study
Authors: Robotham Dan , Evans Joanne , Watson Andrew , Perdue Iain , Craig Thomas , Rose Diana , Wykes Til 
Published: February 2015

Abstract
Introduction
Patients can provide consent to have their clinical records linked to a research register, a process known as consent for contact (C4C). There is evidence about how to engage people with mental illness in C4C, but nothing specific to older adults. This is a priority area for research (for example, dementia trials), although sign-up rates to C4C are lower than for younger populations. Through this study we seek to understand these disparities.

Methods
This was a two-stage cross-sectional observational study. In phase one, focus groups with service users, carers and clinicians informed a framework for clinicians to explain C4C to those on their caseload. In phase two, clinicians explained C4C to 26 service users (and carers where applicable). These conversations were recorded, and their content was analysed. Service users and carers were then interviewed to provide further feedback on their conversations with clinicians. A total of 31 service users, 24 carers and 13 clinical staff took part across the two phases.

Results
In phase one, service users and carers sought assurance of the right to refuse participation in further studies (after joining C4C). Clinicians expressed concerns over legal and practical implications of ascertaining mental capacity and best interest. In phase two, clinicians’ explanations were less thorough than similar explanations given to younger adults with psychosis. Clinicians omitted details of service users’ right to stipulate contact arrangements, which was significantly associated with whether service users/carers agreed to join. Common reasons for joining C4C included altruism and the chance to speak to new people. Few participants refused to join, but reasons included avoidance of stress (potentially alleviated through the presence of a carer).

Conclusions
Implementing C4C in older adults’ services requires clinicians to deliver concise, simple explanations to individuals and their carers where applicable. Older adults can be suspicious of unsolicited contact; thus, explanations must emphasise freedom to negotiate suitable contact arrangements. Hearing about research opportunities can be in the best interests of older adults, but communicating these opportunities requires a tailored approach.
Clinical similarities among bradykinin‐mediated and mast cell‐mediated subtypes of non‐hereditary angioedema: a retrospective study
Authors: Schulkes Karlijn J G , Van den Elzen Mignon T , Hack Erik C , Otten Henderikus G , Bruijnzeel‐Koomen Carla A F M , Knulst André C 
Published: February 2015

AbstractBackgroundNon‐hereditary angioedema (non‐HAE) is characterized by local swelling due to self‐limiting, subcutaneous or submucosal extravasation of fluid, and can be divided into three subtypes. These subtypes are believed to have different pathophysiological backgrounds and are referred to in recent guidelines as bradykinin‐mediated (e.g. caused by angiotensin‐converting‐enzyme‐inhibitors), mast cell‐mediated (e.g. angioedema with wheals) or idiopathic (cause unknown). Bradykinin‐mediated subtypes are more closely related to hereditary angioedema than the other forms. Because clinical features of these non‐HAE subtypes have not been studied in detail, we have looked at the clinical characteristics of symptoms and potential differences in clinical presentation of bradykinin‐mediated and mast cell‐mediated angioedema (AE) subtypes.MethodsA questionnaire was sent to patients presenting with AE at our tertiary outpatient clinic to document clinical characteristics, potential triggers and location of AE. The severity of AE attacks was analysed using visual analogue scales (VAS).ResultsThe questionnaire was returned by 106 patients, of which 104 were included in the analysis. AE with wheals, idiopathic AE, and drug‐associated AE occurred in 64 (62%), 25 (24%) and 15 patients (14%) respectively. Most patients (62%) reported prodromal symptoms while 63% reported multiple locations for an attack. Face and oropharynx were the main locations of AE attacks of any subtype while swelling was the symptom most frequently reported as severe. Overall severity of the last attack was indicated as severe by 68% of the patients. There were no differences between the subgroups.ConclusionThis similarity in clinical presentation raises the possibility that ACEi‐induced, mast cell‐mediated and idiopathic AE share common pathways.
Implementation of hybrid image fusion technique for feature enhancement in medical diagnosis
Authors: Agarwal Jyoti , Bedi Sarabjeet Singh 
Published: February 2015

AbstractImage fusion is used to enhance the quality of images by combining two images of same scene obtained from different techniques. In medical diagnosis by combining the images obtained by Computed Tomography (CT) scan and Magnetic Resonance Imaging (MRI) we get more information and additional data from fused image. This paper presents a hybrid technique using curvelet and wavelet transform used in medical diagnosis. In this technique the image is segmented into bands using wavelet transform, the segmented image is then fused into sub bands using curvelet transform which breaks the bands into overlapping tiles and efficiently converting the curves in images using straight lines. These tiles are integrated together using inverse wavelet transform to produce a highly informative fused image. Wavelet based fusion extracts spatial details from high resolution bands but its limitation lies in the fusion of curved shapes. Therefore for better information and higher resolution on curved shapes we are blending wavelet transform with curvelet transform as we know that curvelet transform deals effectively with curves areas, corners and profiles. These two fusion techniques are extracted and then fused implementing hybrid image fusion algorithm, findings shows that fused image has minimum errors and present better quality results. The peak signal to noise ratio value for the hybrid method was higher in comparison to that of wavelet and curvelet transform fused images. Also we get improved statistics results in terms of Entropy, Peak signal to noise ratio, correlation coefficient, mutual information and edge association. This shows that the quality of fused image was better in case of hybrid method.
Decentralised combined heat and power in the German Ruhr Valley; assessment of factors blocking uptake and integration
Authors: Viétor Birte , Hoppe Thomas , Clancy Joy 
Published: February 2015

Abstract

Background
In Germany, the energy system is undergoing reorganisation from a centralised system based on fossil fuels and nuclear power to a sustainable system based on decentralised production and consumption of energy, the so-called Energiewende. Recently, there has been more attention to improving energy efficiency in those regions where conventional energy production activities and energy-intensive industries are located, such as the Ruhr area. Although the potential for decentralised combined heat and power (CHP) units is high in this region, local action plans show only modest developments for this technology. In this paper, we address this issue by answering the following research question: Which factors block the uptake and integration of decentralised CHP in the German Ruhr area's energy system?

Methods
The multilevel perspective (MLP) was used to analyse the state of system innovation in relation to the uptake and integration of decentralised CHP technology. Prior to the MLP analysis, a stakeholders' analysis was conducted to identify stakeholders' views, positions and experienced barriers regarding the uptake and integration of decentralised CHP technology. Data collection included review of text documents and conducting 11 interviews.

Results
Due to many regime barriers blocking niche development, the uptake of decentralised CHP technology is limited. Identified barriers relate to lack of market services and mismatches with user preferences, (sectoral) policies and industrial interests.

Conclusions
Observed barriers relate to (i) lack of market services such as financial means for making investments; (ii) user awareness such as unawareness and information deficit regarding the benefits of decentralised CHP to potential users, (iii) the presence of centralised district heating systems, (iv) policy issues such as lack of sufficient policies supporting diffusion of decentralised CHP units, legal stipulations from social housing policies that prevent housing cooperatives from becoming energy producers and district heating systems owned by public and private owners (via concessions contracts); (v) sector issues such as lack of skilled service-providing companies; and (vi) industrial interested such as the vested interests of the coal and gas industry. Moreover, many of the mentioned barriers seem interrelated, especially those concerning policy and finance available for making upfront investments.
Patient-specific simulation of tumor growth, response to the treatment, and relapse of a lung metastasis: a clinical case
Authors: Colin Thierry , Cornelis François , Jouganous Julien , Palussière Jean , Saut Olivier 
Published: February 2015

Abstract
In this paper, a parametrization strategy based on reduced order methods is presented for tumor growth PDE models. This is applied to a new simple spatial model for lung metastasis including angiogenesis. The goal is to help clinicians monitoring tumors and eventually predicting their evolution or response to a particular kind of treatment. To illustrate the whole approach, a clinical case including the natural history of the lesion, the response to a chemotherapy, and the relapse before a radiofrequency ablation is presented.
A survey on pulmonary screening practices among otolaryngology-head & neck surgeons across Canada in the post treatment surveillance of head and neck squamous cell carcinoma
Authors: Madana J , Morand Gregoire B , Barona-Lleo Luz , Black Martin J , Mlynarek Alex M , Hier Michael P 
Published: February 2015

Background Post treatment lung screening for head and neck cancer patients primarily focuses on the distant metastasis and a high rate of second primary can also be expected. The best screening tool and timing for this purpose is controversial. We sought out to assess the current practice and beliefs among Canadian Head and Neck Surgeons. Methods After Ethical Board approval, a nationwide survey was conducted through the Canadian Society of Otolaryngology (CSO) among head and neck surgeons regarding their practices for pulmonary screening in HNSCC patients. Results Our CSO survey among Otolaryngology-head and neck surgeons showed that 26 out of 32 respondents perform routine lung screen, out of which 23 (88%) feel that chest radiography should be preferred. The majority of respondents felt that lung screening could impact beneficially on mortality. For symptomatic patients, low-dose spiral CT was the preferred modality (48%), followed by PET/CT scan (14%) and sputum cytology (14%). In high-risk asymptomatic patients (current smoker, radiation exposure, family history and advanced HNSCC), 31% of respondents performed a CXR. The same percentage performed a low dose CT, while 19% relied on PET scan. A further 19% of respondents did not perform any screening in high-risk patients. Most respondents (77%) had more than 10 years practice since graduation from medical school and came from the provinces of Quebec, Ontario and Alberta. Conclusion Chest radiography remains the preferred modality for lung screening and was believed to be impacting beneficially on lung mortality. The recent literature does not seem to be in agreement with those beliefs. Further studies to establish which modality is best and concurrent nation-wide education are warranted.
SAMHD1’s protein expression profile in humans
Authors: Schmidt Sarah , Schenkova Kristina , Adam Tarek , Erikson Elina , Lehmann-Koch Judith , Sertel Serkan , Verhasselt Bruno , Fackler Oliver T , Lasitschka Felix , Keppler Oliver T 
Published: February 2015

Abstract
The deoxynucleoside triphosphate triphosphohydrolase and 3′ → 5′ exonuclease SAMHD1 restricts HIV-1 infection in noncycling hematopoietic cells in vitro, and SAMHD1 mutations are associated with AGS. Little is known about the in vivo expression and functional regulation of this cellular factor. Here, we first assessed the SAMHD1 protein expression profile on a microarray of 25 human tissues from &gt;210 donors and in purified primary cell populations. In vivo, SAMHD1 was expressed in the majority of nucleated cells of hematopoietic origin, including tissue-resident macrophages, DCs, pDCs, all developmental stages of thymic T cells, monocytes, NK cells, as well as at lower levels in B cells. Of note, SAMHD1 was abundantly expressed in HIV target cells residing in the anogenital mucosa, providing a basis for its evaluation as a cellular factor that may impact the efficiency of HIV transmission. Next, we examined the effect of the activation status and proinflammatory cytokine treatment of cells on expression and phosphorylation of SAMHD1. Activated, HIV-susceptible CD4+ T cells carried pSAMHD1(T592), whereas resting CD4+ T cells and macrophages expressed the unphosphorylated protein with HIV-restrictive activity. Surprisingly, stimulation of these primary cells with IFN-α, IFN-γ, IL-4, IL-6, IL-12, IL-18, IL-27, or TNF-α affected neither SAMHD1 expression levels nor threonine 592 phosphorylation. Only IL-1β moderately down-regulated SAMHD1 in activated CD4+ T cells. Taken together, this study establishes the first cross-sectional protein expression profile of SAMHD1 in human tissues and provides insight into its cell cycle-dependent phosphorylation and unresponsiveness to multiple proinflammatory cytokines.
Axillary Ultrasound After Neoadjuvant Chemotherapy and Its Impact on Sentinel Lymph Node Surgery: Results From the American College of Surgeons Oncology Group Z1071 Trial (Alliance)
Authors: Boughey Judy C. , Ballman Karla V. , Hunt Kelly K. , McCall Linda M. , Mittendorf Elizabeth A. , Ahrendt Gretchen M. , Wilke Lee G. , Le-Petross Huong T. 
Published: February 2015

Purpose The American College of Surgeons Oncology Group Z1071 trial reported a 12.6% false-negative rate (FNR) for sentinel lymph node (SLN) surgery after neoadjuvant chemotherapy (NAC) in cN1 disease. Patients were not selected for surgery based on response, but a secondary end point was to determine whether axillary ultrasound (AUS) after NAC after fine-needle aspiration cytology can identify abnormal nodes and guide patient selection for SLN surgery. Patients and Methods Patients with T0-4, N1-2, M0 breast cancer underwent AUS after neoadjuvant chemotherapy. AUS images were centrally reviewed and classified as normal or suspicious lymph nodes. AUS findings were tested for association with pathologic nodal status and SLN FNR. The impact of AUS results to select patients for SLN surgery to reduce the FNR was assessed. Results Postchemotherapy AUS images were reviewed for 611 patients. One hundred thirty (71.8%) of 181 AUS-suspicious patients were node positive at surgery compared with 243 (56.5%) of 430 AUS-normal patients (P < .001). Patients with AUS-suspicious nodes had a greater number of positive nodes and greater metastasis size (P < .001). The SLN FNR was not different based on AUS results; however, using a strategy where only patients with normal AUS undergo SLN surgery would potentially reduce the FNR in Z1071 patients with ≥ two SLNs removed from 12.6% to 9.8% when preoperative AUS results are considered as part of SLN surgery. Conclusion AUS is recommended after chemotherapy to guide axillary surgery. An FNR of 9.8% with the combination of AUS and SLN surgery would be acceptable for the adoption of SLN surgery for women with node-positive breast cancer treated with neoadjuvant chemotherapy.
Childhood Cancer Survivor Study Participants' Perceptions and Understanding of the Affordable Care Act
Authors: Park Elyse R. , Kirchhoff Anne C. , Perez Giselle K. , Leisenring Wendy , Weissman Joel S. , Donelan Karen , Mertens Ann C. , Reschovsky James D. , Armstrong Gregory T. , Robison Leslie L. , Franklin Mariel , Hyland Kelly A. , Diller Lisa R. , Recklitis Christopher J. , Kuhlthau Karen A. 
Published: February 2015

Purpose The Patient Protection and Affordable Care Act (ACA) established provisions intended to increase access to affordable health insurance and thus increase access to medical care and long-term surveillance for populations with pre-existing conditions. However, childhood cancer survivors' coverage priorities and familiarity with the ACA are unknown. Methods Between May 2011 and April 2012, we surveyed a randomly selected, age-stratified sample of 698 survivors and 210 siblings from the Childhood Cancer Survivor Study. Results Overall, 89.8% of survivors and 92.1% of siblings were insured. Many features of insurance coverage that survivors considered “very important” are addressed by the ACA, including increased availability of primary care (94.6%), no waiting period before coverage initiation (79.0%), and affordable premiums (88.1%). Survivors were more likely than siblings to deem primary care physician coverage and choice, protections from costs due to pre-existing conditions, and no start-up period as “very important” (P < .05 for all). Only 27.3% of survivors and 26.2% of siblings reported familiarity with the ACA (12.1% of uninsured v 29.0% of insured survivors; odds ratio, 2.86; 95% CI, 1.28 to 6.36). Only 21.3% of survivors and 18.9% of siblings believed the ACA would make it more likely that they would get quality coverage. Survivors' and siblings' concerns about the ACA included increased costs, decreased access to and quality of care, and negative impact on employers and employees. Conclusion Although survivors' coverage preferences match many ACA provisions, survivors, particularly uninsured survivors, were not familiar with the ACA. Education and assistance, perhaps through cancer survivor navigation, are critically needed to ensure that survivors access coverage and benefits.
Risk Factors and Tumor Characteristics of Interval Cancers by Mammographic Density
Authors: Holm Johanna , Humphreys Keith , Li Jingmei , Ploner Alexander , Cheddad Abbas , Eriksson Mikael , Törnberg Sven , Hall Per , Czene Kamila 
Published: February 2015

Purpose To compare tumor characteristics and risk factors of interval breast cancers and screen-detected breast cancers, taking mammographic density into account. Patients and Methods Women diagnosed with invasive breast cancer from 2001 to 2008 in Stockholm, Sweden, with data on tumor characteristics (n = 4,091), risk factors, and mammographic density (n = 1,957) were included. Logistic regression was used to compare interval breast cancers with screen-detected breast cancers, overall and by highest and lowest quartiles of percent mammographic density. Results Compared with screen-detected breast cancers, interval breast cancers in nondense breasts (≤ 20% mammographic density) were significantly more likely to exhibit lymph node involvement (odds ratio [OR], 3.55; 95% CI, 1.74 to 7.13) and to be estrogen receptor negative (OR, 4.05; 95% CI, 2.24 to 7.25), human epidermal growth factor receptor 2 positive (OR, 5.17; 95% CI, 1.64 to 17.01), progesterone receptor negative (OR, 2.63; 95% CI, 1.58 to 4.38), and triple negative (OR, 5.33; 95% CI, 1.21 to 22.46). In contrast, interval breast cancers in dense breasts (> 40.9% mammographic density) were less aggressive than interval breast cancers in nondense breasts (overall difference, P = .008) and were phenotypically more similar to screen-detected breast cancers. Risk factors differentially associated with interval breast cancer relative to screen-detected breast cancer after adjusting for age and mammographic density were family history of breast cancer (OR, 1.32; 95% CI, 1.02 to 1.70), current use of hormone replacement therapy (HRT; OR, 1.84; 95% CI, 1.38 to 2.44), and body mass index more than 25 kg/m2 (OR, 0.49; 95% CI, 0.29 to 0.82). Conclusion Interval breast cancers in women with low mammographic density have the most aggressive phenotype. The effect of HRT on interval breast cancer risk is not fully explained by mammographic density. Family history is associated with interval breast cancers, possibly indicating disparate genetic background of screen-detected breast cancers and interval breast cancers.
Metabolic Changes Induced by the Biliopancreatic Diversion in Diet-Induced Obesity in Male Rats: The Contributions of Sleeve Gastrectomy and Duodenal Switch
Authors: Baraboi Elena-Dana , Li Wei , Labbé Sébastien M. , Roy Marie-Claude , Samson Pierre , Hould Frédéric-Simon , Lebel Stéphane , Marceau Simon , Biertho Laurent , Richard Denis 
Published: February 2015

AbstractThe mechanisms underlying the body weight and fat loss after the biliopancreatic diversion with duodenal switch (BPD/DS) remain to be fully delineated. The aim of this study was to examine the contributions of the two main components of BPD/DS, namely sleeve gastrectomy (SG) and duodenal switch (DS), on energy balance changes in rats rendered obese with a high-fat (HF) diet. Three different bariatric procedures (BPD/DS, SG, and DS) and three sham surgeries were performed in male Wistar rats. Sham-operated animals fed HF were either fed ad libitum (Sham HF) or pair weighed (Sham HF PW) by food restriction to the BPD/DS rats. A group of sham-operated rats was kept on standard chow and served as normal diet control (Sham Chow). All three bariatric surgeries resulted in a transient reduction in food intake. SG per se induced a delay in body weight gain. BPD/DS and DS led to a noticeable gut malabsorption and a reduction in body weight and fat gains along with significant elevations in plasma levels of glucagon-like peptide-17–36 and peptide YY. BPD/DS and DS elevated energy expenditure above that of Sham HF PW during the dark phase. However, they reduced the volume, oxidative metabolism, and expression of thermogenic genes in interscapular brown adipose tissue. Altogether the results of this study suggest that the DS component of the BPD/DS, which led to a reduction in digestible energy intake while sustaining energy expenditure, plays a key role in the improvement in the metabolic profile led by BPD/DS in rats fed a HF diet.