bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Dental Arch Widths and Interarch Relationships in Children with Operated Unilateral Complete Cleft Lip and Palate
Authors: Patrícia Bittencourt Dutra Dos Santos , Janson Guilherme , Assis Vivian Helena , De Paula Leite Battisti Maira , Garib Daniela Gamba 
Published: August 2013

Objective Palate and lip repair have great influence on the sagittal and transverse growth of the maxilla. The correlation between arch widths and sagittal interarch relationships in operated patients with complete unilateral cleft lip and palate (UCLP) in the mixed dentition is not clear. The aim of this study was to compare the maxillary arch widths of patients with UCLP and different interarch relationships (GOSLON Yardstick index) Methods The study sample consisted of 144 pairs of dental casts of patients with complete UCLP from 8 to 10 years of age, from a single center. These dental casts were divided into three groups: group I (patients with GOSLON Yardstick 1 and 2 interarch relationships), group II (GOSLON Yardstick 3), and group III (GOSLON Yardstick 4 and 5). The control group consisted of 40 pairs of dental casts of noncleft Class I patients at the same age range. The maxillary and mandibular arch widths were measured at canine, deciduous molars, and permanent first molar regions. Intergroup comparisons were performed by analysis of variance followed by Tukey tests ( P < .05) Results Maxillary arch widths were significantly smaller in all three groups with repaired UCLP compared to the control group. Group III showed reduced intercanine and second deciduous molar widths compared to group I. No intergroup differences were observed for mandibular arch widths. Conclusions Operated UCLP patients with more severe sagittal discrepancies tend to show more severe transverse maxillary arch deficiencies.
Investigation of Parental Transmission of RUNX2 Single Nucleotide Polymorphism and Its Association with Nonsyndromic Cleft Lip with or Without Palate
Authors: Jung Seung Hee , Lee Ah-Young , Park Ji Wan , Baek Seung-Hak , Kim Young Ho 
Published: August 2013

Objective To investigate the association and parental transmission of RUNX2 single nucleotide polymorphisms (SNPs) with risk of nonsyndromic cleft lip with or without cleft palate (NS-CL±P). Design Four RUNX2 SNPs in 142 Korean NS-CL±P families (nine cleft lip, 26 cleft lip and alveolus, and 107 cleft lip and palate; 76 trios and 66 dyads) were genotyped. The minor allele frequency, heterozygosity, and chi-square test for Hardy-Weinberg equilibrium at each SNP were computed between parents. Pairwise linkage disequilibrium was computed as D′ and r2 for all SNPs. Both allelic and genotypic transmission disequilibrium tests (TDTs) were performed for individual SNPs using a family-based association test program. Sliding windows of haplotypes consisting of two to four SNPs were tested using a haplotype-based association test program. Genotypic odds ratios (GORs) were calculated from conditional logistic regression models. Parent-of-origin effects were assessed using transmission asymmetry test and parent-of-origin likelihood ratio test. Results The family-based TDT showed significant evidence of linkage and association at rs1934328 ( P = .001). In the haplotype analysis, two, three, and four haplotypes containing rs1934328 revealed significant associations ( P = .0017, P = .0022, and P = .0020, respectively). The genotypes A/T and T/T at rs1934328 were significantly associated with NS-CL±P compared with the genotype A/A (GOR = 2.75, 95% confidence interval [CI] = 1.39–5.45, P =0.0019 in the dominant model; GOR = 5.38, 95% CI = 1.34–21.68, P = .0046 in the additive model). However, no parent-of origin effect was observed. Conclusion These findings suggest possible involvement of RUNX2-rs 194328 in the etiology of NS-CL±P in Korean cleft-parent trios without excess parental transmission.
Effect of Nanocrystalline Calcium Sulfate Bone Graft in a Bilateral Sinus‐Augmentation Procedure: A Case Report
Authors: Mazor Ziv , Mamidwar Sachin 
Published: August 2013

Introduction: Patients with an edentulous posterior maxillary segment frequently lack adequate bone mass to support dental implants. Implant placement into the posterior maxillary ridge can be complicated by limited quantity and poor quality of bone. Sinus lift and bone grafting result in bone regeneration as well as an increase in bone volume and hence help stabilize implants. The challenge of bone deficiency of this segment has been traditionally addressed by two approaches: 1) lateral maxillary window (hinge osteotomy) and 2) the crestal approach via osteotome technique.Case Presentation: A 70‐year‐old female patient presented needing a full maxillary rehabilitation. The osteotome‐closed approach was used on the right side, which was grafted with nanocrystalline calcium sulfate (nCS) bone graft. The lateral window sinus elevation approach was used on the left side, which was grafted with nCS in combination with platelet‐rich fibrin. Implants were placed simultaneously. Computed tomography scans showed bone formation in the augmented sites at 6 months. Implants were restored at this time. A 2‐year follow‐up showed satisfactory results with good implant stability.Conclusion: This case demonstrates the effective use of nCS for sinus‐augmentation cases.
Analytical Model for Unconventional Multifractured Composite Systems
Authors: Stalgorova Ekaterina , Mattar Louis 
Published: August 2013

Summary
This paper presents an analytical model for unconventional reservoirs with horizontal wells with multiple fractures. The model is an extension of the "trilinear flow" solution, but it subdivides the reservoir into five regions instead of three. This enables it to be used for more-complex reservoirs. Accordingly, the model can simulate a fracture that is surrounded by a stimulated region of limited extent (fracture branching), whereas the remaining reservoir is nonstimulated. In addition to modeling flow within the fracture and flow within the stimulated region, the model takes into account flow from the surrounding nonstimulated region, both parallel to and perpendicular to the fracture.
The model can be used to simulate the flow in tight reservoirs with multifractured horizontal wells. In many cases, the fractures do not have a simple biwing shape, but are branched. This effectively creates regions of higher permeability around each fracture, which obviously affect the production performance significantly. However, in many tight reservoirs, in spite of their low permeability, the surrounding nonstimulated region can also be a significant contributor to long-term production. The five-region model accounts for this contribution. Thus, it is particularly valuable when generating production forecasts for reserves evaluation.
The model was validated by comparing its results with numerical simulation. We found that analytical and numerical results are in good agreement only when the geometry of the system falls within certain limitations. However, these limitations are met in most cases of interest. Therefore, the model is useful for practical engineering purposes.
Decreased Exhaled Nitric Oxide Levels in Patients with Mitochondrial Disorders
Authors: Mosquera Ricardo A. , Samuels Cheryl L. , Harris Tomika S. , Yadav Aravind , Hashmi S. Shahrukh , Knight Melissa S. , Koenig Mary Kay 
Published: August 2013

Background:Nitric oxide (NO) deficiency may occur in mitochondrial disorders (MD) and can contribute to the pathogenesis of the disease. It is difficult and invasive to measure systemic nitric oxide. NO is formed in the lungs and can be detected in expired air. Currently, hand-held fractional exhaled nitric oxide (FeNO) measurement devices are available enabling a fast in-office analysis of this non-invasive test. It was postulated that FeNO levels might be reduced in MD.Methods:Sixteen subjects with definite MD by modified Walker criteria (4 to 30 years of age) and sixteen healthy control subjects of similar age, race and body mass index (BMI) underwent measurement of FeNO in accordance with the American Thoracic Society guidelines.Results:Sixteen patient-control pairs were recruited. The median FeNO level was 6.5 ppm (IQR: 4-9.5) and 10.5 ppm (IQR: 8-20.5) in the MD and control groups, respectively. In 13 pairs (81%), the FeNO levels were lower in the MD cases than in the matched controls (p=0.021). Eleven (69%) cases had very low FeNO levels (≤7ppm) compared to only 1 control (p=0.001). All cases with enzymatic deficiencies in complex I had FeNO ≤7ppm.Conclusions:Single-breath exhaled nitric oxide recordings were decreased in patients with MD. This pilot study suggests that hand-held FeNO measurements could be an attractive non-invasive indicator of MD. In addition, measurement of FeNO could be used as a parameter to monitor therapeutic response in this population.
Detection of main tidal frequencies using least squares harmonic estimation method
Authors: Mousavian R. , Hossainali M. Mashhadi 
Published: August 2013

AbstractIn this paper the efficiency of the method of Least Squares Harmonic Estimation (LS-HE) for detecting the main tidal frequencies is investigated. Using this method, the tidal spectrum of the sea level data is evaluated at two tidal stations: Bandar Abbas in south of Iran and Workington on the eastern coast of the UK. The amplitudes of the tidal constituents at these two tidal stations are not the same. Moreover, in contrary to the Workington station, the Bandar Abbas tidal record is not an equispaced time series. Therefore, the analysis of the hourly tidal observations in Bandar Abbas and Workington can provide a reasonable insight into the efficiency of this method for analyzing the frequency content of tidal time series. Furthermore, applying the method of Fourier transform to the Workington tidal record provides an independent source of information for evaluating the tidal spectrum proposed by the LS-HE method. According to the obtained results, the spectrums of these two tidal records contain the components with the maximum amplitudes among the expected ones in this time span and some new frequencies in the list of known constituents. In addition, in terms of frequencies with maximum amplitude; the power spectrums derived from two aforementioned methods are the same. These results demonstrate the ability of LS-HE for identifying the frequencies with maximum amplitude in both tidal records.
GPS baseline configuration design based on robustness analysis
Authors: Yetkin M. , Berber M. 
Published: August 2013

AbstractThe robustness analysis results obtained from a Global Positioning System (GPS) network are dramatically influenced by the configurationof the observed baselines. The selection of optimal GPS baselines may allow for a cost effective survey campaign and a sufficiently robustnetwork. Furthermore, using the approach described in this paper, the required number of sessions, the baselines to be observed, and thesignificance levels for statistical testing and robustness analysis can be determined even before the GPS campaign starts. In this study, wepropose a robustness criterion for the optimal design of geodetic networks, and present a very simple and efficient algorithm based on thiscriterion for the selection of optimal GPS baselines. We also show the relationship between the number of sessions and the non-centralityparameter. Finally, a numerical example is given to verify the efficacy of the proposed approach.
Referencing regional geoid-based vertical datums to national tide gauge networks
Authors: Bolkas D. , Fotopoulos G. , Sideris M. G. 
Published: August 2013

AbstractThe objective of this study is to investigate the best means for referencing a regional geoid-based vertical datum to a network of tide gauges. In this study, a network of 27 tide gauge stations scattered along the coasts of Canada are used in order to assess the replacement of the conventionally derived Canadian Geodetic Vertical Datum of 1928 with a geoid-based datum. This is in-line with the future implementation plan of Canada’s geoid-based vertical height system. A mixed least-squares adjustment was performed for various scenarios, including satellite-only global geoid models, combined global geoid models and regional geoid models. In addition, various sea surface topography and vertical ground motion models were tested for estimating orthometric heights. The resulting approximation of a local equipotential surface is compared to previously published values and considerations for referencing a geoid-based vertical datum to tide gauge networks are emphasized.
Towards a vertical datum standardisation under the umbrella of Global Geodetic Observing System
Authors: Sánchez L. 
Published: August 2013

AbstractMost of the existing height systems refer to local sea surface levels, are stationary (do not consider variations in time), and realise different physical height types (orthometric, normal, normal-orthometric, etc.). In general, their accuracy is about two orders of magnitude less than that of the realisation of geometric reference systems (sub millimetre level). The Global Geodetic Observing System (GGOS) of the International Association of Geodesy (IAG), taking care of providing a precise geodetic infrastructure for monitoring the system Earth, promotes the standardisation of height systems worldwide. The main objectives are: (1) to provide a reliable frame for consistent analysis and modelling of global phenomena and processes affecting the Earth’s gravity field and the Earth’s surface geometry; and (2) to support the precise combination of physical and geometric heights in order to exploit at a maximum the advantages of satellite geodesy (e.g. combination of satellite positioning and gravity field models for worldwide unified precise height determination). According to this, the GGOS Theme 1 ”Unified Height System” was established in February 2010 with the purpose to bring together existing initiatives and to address the activities to be faced. Starting point are the results delivered by the IAG Inter-Commission Project 1.2 ”Vertical Reference Frames” during the period 2003-2011. The present actions related to the vertical datum homogenisation are being coordinated by the working group ”Vertical Datum Standardisation”, which directly depends on the GGOS Theme 1 and is supported by the IAG Commissions 1 (Reference Frames) and 2 (Gravity Field), as well as by the International Gravity Field Service (IGFS). This paper discusses some aspects to take into consideration for the realisation of a standardised globally unified vertical reference system.
Evaluation of W0 in Canada using tide gauges and GOCE gravity field models
Authors: Hayden T. , Rangelova E. , Sideris M. G. , Véronneau M. 
Published: August 2013

AbstractThe existing Canadian Geodetic Vertical Datum of 1928 (CGVD28) does not meet the needs of the modern user in terms of accuracy and accessibility. As a result, Canada plans to implement a geoid-based and global navigation satellite system (GNSS)-accessible vertical datum by 2013. One of the primary concerns in realizing this new vertical datum is to determine a W0 value that will represent the potential of the zero height surface. The objective of this study is to evaluate W0 by averaging the potential of points on the mean sea water surface utilizing tide gauge recordings and gravity field and steady-state ocean circulation explorer (GOCE)-based global geopotential models. In order to assess the performance of the GOCE-based models for the computation of W0, the models are extended with the high resolution gravitational model EGM2008. Regional gravimetric geoid models are also used for the estimation of W0. Additionally, local sea surface topography models are utilized in order to validate the W0 results at the tide gauges. Excluding the Arctic coast, the W0 values obtained from both tide gauges and oceanic sea surface topography models are not statistically different from the International Earth Rotation and Reference Systems Service (IERS) 2010 global conventional value 62636856.00 m2/s2.
How Significant is the Dynamic Component of the North American Vertical Datum?
Authors: Rangelova E. , Wal W. Van Der , Sideris M.G. 
Published: August 2013

AbstractOne of the main current geodetic activities in North America is the definition and establishment of a geoid-based vertical datum that will replace the official CGVD28 and NAVD88 datums in Canada and the USA, respectively. The new datum will also have a time-dependent (dynamic) component required by the targeted one-centimetre accuracy of the datum. Heights of the levelling benchmarks are subject to temporal changes, which contribute to the degradation of the accuracy of the datum and increase the misfit of the geoid heights determined gravimetrically and by GNSS/levelling. The zero level surface, i.e., the geoid, also changes with time, most significantly due to postglacial rebound, climate-induced loss of polar ice masses and mountain glaciers, and hydrology variations. In this study, we examine the possible changes of the datum due to the aforementioned factors. We are mostly concerned with postglacial rebound as it can contribute more than 1 mm per year and more than 1 cm per decade to the geoid change. We also assess the significance of the temporal geoid and benchmark height changes and show that, compared to its current accuracy, the geoid change is only significant after a decade mostly in the flat areas of central Canada.
Regional geoid-model-based vertical datums – some Australian perspectives
Authors: Featherstone W. E. , Filmer M. S. , Claessens S. J. , Kuhn M. , Hirt C. , Kirby J. F. 
Published: August 2013

AbstractThis article summarises some considerations surrounding a geoid-model-based vertical datum that have to be thought through before its implementation and adoption. Our examples are based on many Australian and some South-East Asian experiences, but these probably also apply elsewhere. The key considerations comprise data quality and availability, politics, and difficulties that users may encounter when adopting quite a different approach to height determination. We advocate some form of new vertical datum to replace the Australian Height Datum, but the exact type (whether using levelling or geoid, or some combination of both) still needs to be decided. We are not specifically opposed to the adoption of a geoid model as the vertical datum, but it is possibly more challenging than appears initially, and may even deter some users that are already well served by levelling-based vertical datums.
Transsylvian hippocampal transection for mesial temporal lobe epilepsy: surgical indications, procedure, and postoperative seizure and memory outcomes
Authors: Uda Takehiro , Morino Michiharu , Ito Hirotaka , Minami Noriaki , Hosono Atsushi , Nagai Taiki , Matsumoto Takahiro 
Published: August 2013

Object
Amygdalohippocampectomy is a well-established, standard surgery for medically intractable mesial temporal lobe epilepsy (MTLE). However, in the case of MTLE without hippocampal atrophy or sclerosis, amygdalohippocampectomy is associated with decreased postoperative memory function. Hippocampal transection (HT) has been developed to overcome this problem. In HT the hippocampus is not removed; rather, the longitudinal hippocampal circuits of epileptic activities are disrupted by transection of the pyramidal layer of the hippocampus. The present study describes a less invasive modification of HT (transsylvian HT) and presents the seizure and memory outcomes for this procedure.

Methods
Thirty-seven patients with MTLE (18 men and 19 women; age range 9–63 years; 19 with surgery on the right side and 18 with surgery on the left side; seizure onset from 3 to 34 years) who were treated with transsylvian HT were retrospectively analyzed. All patients had left-side language dominance, and follow-up periods ranged from 12 to 94 months (median 49 months). Seizure outcomes were evaluated for all patients by using the Engel classification. Memory function was evaluated for 22 patients based on 3 indices (verbal memory, nonverbal memory, and delayed recall), with those scores obtained using the Wechsler Memory Scale–Revised. Patients underwent evaluation of the memory function before and after surgery (6 months–1 year).

Results
Engel Class I (completely seizure free) was achieved in 25 patients (67.6%). Class II and Class III designation was achieved in 10 (27%) and 2 patients (5.4%), respectively. There were differences in memory outcome between the sides of operation. On the right side, verbal memory significantly increased postoperatively (p = 0.003) but nonverbal memory and delayed recall showed no significant change after the operation (p = 0.718 and p = 0.210, respectively). On the left side, all 3 indices (verbal memory, nonverbal memory, and delayed recall) showed no significant change (p = 0.331, p = 0.458, and p = 0.366, respectively).

Conclusions
Favorable seizure outcome and preservation of verbal memory were achieved with transsylvian HT for the treatment of MTLE without hippocampal atrophy or sclerosis.