bluuebunny/crossref_metadata_2025_split huggingface dataset:
MYCBPAP is a central apparatus protein required for centrosome–nuclear envelope docking and sperm tail biogenesis in mice
Authors: Wang Haoting , Kobayashi Hiroko , Shimada Keisuke , Oura Seiya , Oyama Yuki , Kitakaze Hiroaki , Noda Taichi , Yabuta Norikazu , Miyata Haruhiko , Ikawa Masahito 
Published: August 2024

ABSTRACT
The structure of the sperm flagellar axoneme is highly conserved across species and serves the essential function of generating motility to facilitate the meeting of spermatozoa with the egg. During spermiogenesis, the axoneme elongates from the centrosome, and subsequently the centrosome docks onto the nuclear envelope to continue tail biogenesis. Mycbpap is expressed predominantly in mouse and human testes and conserved in Chlamydomonas as FAP147. A previous cryo-electron microscopy analysis has revealed the localization of FAP147 to the central apparatus of the axoneme. Here, we generated Mycbpap-knockout mice and demonstrated the essential role of Mycbpap in male fertility. Deletion of Mycbpap led to disrupted centrosome–nuclear envelope docking and abnormal flagellar biogenesis. Furthermore, we generated transgenic mice with tagged MYCBPAP, which restored the fertility of Mycbpap-knockout males. Interactome analyses of MYCBPAP using Mycbpap transgenic mice unveiled binding partners of MYCBPAP including central apparatus proteins, such as CFAP65 and CFAP70, which constitute the C2a projection, and centrosome-associated proteins, such as CCP110. These findings provide insights into a MYCBPAP-dependent regulation of the centrosome–nuclear envelope docking and sperm tail biogenesis.
A new biomechanical model of the mammal jaw based on load path analysis
Authors: Wilken Alec T. , Schultz Julia A. , Luo Zhe-Xi , Ross Callum F. 
Published: August 2024

ABSTRACT
The primary function of the tetrapod jaw is to transmit jaw muscle forces to bite points. The routes of force transfer in the jaw have never been studied but can be quantified using load paths – the shortest, stiffest routes from regions of force application to support constraints. Here, we use load path analysis to map force transfer from muscle attachments to bite point and jaw joint, and to evaluate how different configurations of trabecular and cortical bone affect load paths. We created three models of the mandible of the Virginia opossum, Didelphis virginiana, each with a cortical bone shell, but with different material properties for the internal spaces: (1) a cortical-trabecular model, in which the interior space is modeled with bulk properties of trabecular bone; (2) a cortical-hollow model, in which trabeculae and mandibular canal are modeled as hollow; and (3) a solid-cortical model, in which the interior is modeled as cortical bone. The models were compared with published in vivo bite force and bone strain data, and the load paths calculated for each model. The trabecular model, which is preferred because it most closely approximates the actual morphology, was best validated by in vivo data. In all three models, the load path was confined to cortical bone, although its route within the cortex varied depending on the material properties of the inner model. Our analysis shows that most of the force is transferred through the cortical, rather than trabecular bone, and highlights the potential of load path analysis for understanding form–function relationships in the skeleton.
Integrated cellular response of the zebrafish (Danio rerio) heart to temperature change
Authors: Shaftoe Jared B. , Geddes-McAlister Jennifer , Gillis Todd E. 
Published: August 2024

ABSTRACT
A decrease in environmental temperature represents a challenge to the cardiovascular system of ectotherms. To gain insight into the cellular changes that occur during cold exposure and cold acclimation we characterized the cardiac phosphoproteome and proteome of zebrafish following 24 h or 1 week exposure to 20°C from 27°C; or at multiple points during 6 weeks of acclimation to 20°C from 27°C. Our results indicate that cold exposure causes an increase in mitogen-activated protein kinase signalling, the activation of stretch-sensitive pathways, cellular remodelling via ubiquitin-dependent pathways and changes to the phosphorylation state of proteins that regulate myofilament structure and function including desmin and troponin T. Cold acclimation (2–6 weeks) led to a decrease in multiple components of the electron transport chain through time, but an increase in proteins for lipid transport, lipid metabolism, the incorporation of polyunsaturated fatty acids into membranes and protein turnover. For example, there was an increase in the levels of apolipoprotein C, prostaglandin reductase-3 and surfeit locus protein 4, involved in lipid transport, lipid metabolism and lipid membrane remodelling. Gill opercular movements suggest that oxygen utilization during cold acclimation is reduced. Neither the amount of food consumed relative to body mass nor body condition was affected by acclimation. These results suggest that while oxygen uptake was reduced, energy homeostasis was maintained. This study highlights that the response of zebrafish to a decrease in temperature is dynamic through time and that investment in the proteomic response increases with the duration of exposure.
Implications of chronic hypoxia during development in red drum
Authors: Negrete Benjamin , Ackerly Kerri Lynn , Esbaugh Andrew J. 
Published: August 2024

ABSTRACT
Respiratory plasticity is a beneficial response to chronic hypoxia in fish. Red drum, a teleost that commonly experiences hypoxia in the Gulf of Mexico, have shown respiratory plasticity following sublethal hypoxia exposure as juveniles, but implications of hypoxia exposure during development are unknown. We exposed red drum embryos to hypoxia (40% air saturation) or normoxia (100% air saturation) for 3 days post fertilization (dpf). This time frame encompasses hatch and exogenous feeding. At 3 dpf, there was no difference in survival or changes in size. After the 3-day hypoxia exposure, all larvae were moved and reared in common normoxic conditions. Fish were reared for ∼3 months and effects of the developmental hypoxia exposure on swim performance and whole-animal aerobic metabolism were measured. We used a cross design wherein fish from normoxia (N=24) were exercised in swim tunnels in both hypoxia (40%, n=12) and normoxia (100%, n=12) conditions, and likewise for hypoxia-exposed fish (n=10 in each group). Oxygen consumption, critical swim speed (Ucrit), critical oxygen threshold (Pcrit) and mitochondrial respiration were measured. Hypoxia-exposed fish had higher aerobic scope, maximum metabolic rate, and higher liver mitochondrial efficiency relative to control fish in normoxia. Interestingly, hypoxia-exposed fish showed increased hypoxia sensitivity (higher Pcrit) and recruited burst swimming at lower swim speeds relative to control fish. These data provide evidence that early hypoxia exposure leads to a complex response in later life.
Comparison of Halal Product Standards in Indonesia and the Kingdom of Saudi Arabia
Authors: Khoiriah Ulfah Lailatul , Prasiefa Mizanurafi’ Ghifarhadi , Gunawan Gunawan , Gunawan Setiyo 
Published: August 2024

In the era of globalization and increasingly fierce economic competition, halal industry opportunities are an important focus of the government in understanding the dynamics of the global market. The rapid growth of the Muslim market is partly due to the high birth rate of Muslims compared to the birth rate in Western countries. This high growth has the potential to drive an increase in the market as well as the global economy because Muslims generally seek Halal products that are made following Islamic principles. The government continues to strive to develop this industry and make various regulations to regulate the entire process that occurs. Halal standards that apply in each country are, of course, different, and tailored to the conditions and needs of the country. The main purpose of this research is to analyze and compare the practice and regulation of halal products in Indonesia and Saudi Arabia. Based on comparative and qualitative analysis, it can be concluded that halal policies in Indonesia and Saudi Arabia have several significant differences, such as halal policies, procedures and provisions in halal certification, types of halal mandatory products, and slaughter criteria.
Two-photon 3D printed fiber-optic Fabry–Perot probe for triaxial contact force detection of guidewire tips
Authors: Yin Ruixue , Yang Yuhang , Hou Linsong , Wei Heming , Zhang Hongbo , Zhang Wenjun 
Published: August 2024

The demand for real-time feedback and miniaturization of sensing elements is a crucial issue in the treating vascular diseases with minimally invasive interventions. Here, Fabry–Perot microcavities fabricated via direct laser writing using a two-photon polymerization technique on fiber tips are proposed, designed, simulated, and experimentally demonstrated as a miniature triaxial force sensor for monitoring real-time interactions between the tip of a guidewire and human blood vessels and tissues during minimally invasive surgeries. The sensor contains four fiber tip-based Fabry–Perot cavities, which can be seamlessly integrated into medical guidewires and achieves three-axis force decoupling through symmetrically arranged flexible structures. The results showed that the proposed sensor achieved a cross-sectional diameter of 890 μm and a high sensitivity of about 85.16 nm/N within a range of 0 to 0.5 N with a resolution of hundreds of micro-Newtons. The proposed triaxial force sensor exhibits high resolution, good biocompatibility, and electromagnetic compatibility, which can be utilized as an efficient monitoring tool integrated into minimally invasive surgical intervention devices for biomedical applications.
The psychosocial impacts of skin-neglected tropical diseases (SNTDs) as perceived by the affected persons: A systematic review
Authors: Alderton Dasha L. , Ackley Caroline , Trueba Mei L. 
Published: August 2024

Background
Neglected Tropical Diseases (NTDs) disproportionately affect marginalised groups within impoverished communities, conferring devastating physical, financial and psychosocial effects. Skin-NTDs (SNTDs) are uniquely stigmatising due to their visible nature, rendering affected individuals vulnerable to psychosocial risk and the associated decline in social participation, quality of life and mental health. In response to knowledge gaps identified by current global efforts for integrated control of SNTDs this review gathers existing evidence on the psychosocial effects of SNTDs, with consideration given to the influence of gender.

Methods
The study protocol is registered with PROSPERO (CRD42022336676). Data was collected from Embase, Global Health, Medline and Web of Science, with additional articles identified through Google Scholar and bibliography tracking. Qualitative studies published in English between 2005 and 2024 reporting men’s and women’s experiences with SNTDs were searched. Appropriate data from each included study were inputted into NVivo software to facilitate thematic synthesis. Descriptive and analytic themes were generated through line-by-line coding using an inductive approach.

Results
27 articles of high and moderate quality were included. They pertained to buruli ulcer, cutaneous leishmaniasis, leprosy, lymphatic filariasis, tungiasis, onchocerciasis, schistosomiasis and podoconiosis. Men and women across SNTDs and contexts reported debilitating physical symptoms which impaired their ability to work, socialise and carry out usual daily activities. Some felt (at least initially) well supported by partners and relatives, whereas most experienced avoidance, abandonment and even violence, with women incurring worse SNTD-related social consequences. Many men and most women experienced stigma, with discriminatory behaviours largely attributed to fear of infection, decreased ability to perform gender-specific daily activities, and the perceived association between SNTDs and sinfulness. Self-reported impacts of SNTDs on men’s and women’s mental wellbeing included low mood, anxiety, low self-esteem, and suicidal ideation. Disease-specific knowledge, early treatment, social support, and disease acceptance were mentioned as protective factors.

Conclusion
SNTDs cause significant psychosocial harms, particularly for women. Implementing myth-busting and contact-based educational campaigns and improving access to treatment and to livelihood opportunities and social protection schemes for men and women with a SNTD will help prevent and mitigate these.
An unclosed loop: Perspectives of community engagement in infectious disease clinical trials in sub-Saharan Africa
Authors: Späth Carmen , Schmidt Bey-Marrié 
Published: August 2024

Background
Community engagement (CE) is pertinent to ethically and scientifically rigorous infectious disease clinical trials in sub-Saharan Africa (SSA). However, there are critiques that CE is not properly embedded in research processes and that there is uncertainty about what CE entails. The aim of this study was to gain an understanding of CE in infectious disease clinical trials in SSA, specifically factors affecting CE and existing strategies for engaging with communities.

Methods
Semi-structured telephone interviews were conducted with 20 community and clinical trial (CT) stakeholders who worked in SSA. The audio-recorded interviews were transcribed verbatim and analysed inductively using thematic analysis.

Results
Themes are as follows: 1) Communities are abandoned research-entities—a disconnect between scientific teams and communities was observed and knowledge translation was not prioritised at the community-level. 2) Us and them: community engagement teams vs investigators—CE teams expressed that researchers did not account for CE processes and often did not involve CE staff in their planning, and felt that their roles were not valued. 3) Ethical considerations: concerns and gaps—there were concerns that procedures were not standardised and that ethics processes were not adhered to. 4) Opportunities for improved CE practices—training needs were expressed, including for standardised practices, ethics, and for developing a holistic understanding of collaborating with communities.

Conclusion
CE role players require intensive training to ensure ethical CE and that communities are treated with dignity. This includes 1) using collaborative strategies involving research and CE staff, 2) protocol-adherence that recognises CE as pertinent, 3) viewing communities as complex and building relationships that are sustainable, and 4) ensuring that knowledge translation is considered at a community-level. Further research is necessary to investigate potential training programmes that integrate these elements.
The Role of Ethics Education in the Fight Against Corruption
Authors: Ndiku Judah Mualuko , Nasongo Joseph W. , Odero Monica 
Published: August 2024

Education has an integral role to inculcate morality in learners. It is expected that education should produce responsible persons who can be trusted in promoting the well-being of society. An educated individual according to Julius Nyerere is one who is ready to serve the masses, realize and recognize themselves as being part of the society. The current world requires education that can make its citizens grow into morally responsible individuals whose actions promote justice in society. Bearing in mind that unless corruption is eliminated within and through the education system, society will continue to be captive of corruption. Society today, has overlooked the prime duty of imparting knowledge of morals into its citizens. This has however resulted into the growth of citizens whose morals are in question. Ethics plays a vital role in education since it acts as a basis of identifying the wrong and right and the training of the human will to pursue what is right. Corruption is a wrong doing that can be dealt with when people come into agreement and understanding of their place, place of others and the reasons for respecting every individual’s capabilities (need to address the common good. i.e. resources, public office, public funds). Individuals with deeper understanding of morality tend to uphold transparency and accountability. Such individuals shun away from acts of corruption since they know and understand the consequences of every action they partake. Schools therefore have a responsibility of ensuring that all students who undergo the education processes are morally equipped with knowledge and skills of the do’s and don’ts. This paper therefore aims at examining the place of ethics in secondary school education and the extent to which education ought to contribute towards the war against corruption in Africa.
Studi Potensi Penghematan Energi pada Coal Handling System PLTU Jawa IV Menggunakan Analisis Regresi Multivarian
Authors: Hastanto Ari , T.K Berkah Fajar , Windarta Jaka 
Published: August 2024

Pembangkit Listrik Tenaga Uap (PLTU) Jawa IV merupakan salah satu PLTU berdaya terbesar di Indonesia yang memiliki transportasi batubara dari Jetty menuju Bunker sepanjang lebih dari lima kilometer, dan dikelola Coal Handling System (CHS). United Nations Industrial Development Organization (UNIDO) memberikan pedoman pengelolaan energi berdasarkan ISO 50001 di sektor industri. Pedoman ini menghasilkan keluaran pada pengguna energi terbesar CHS yang dijadikan obyek utama penghematan energi, yaitu sistem konveyor. Pengoperasian sistem konveyor CHS yang panjang dengan struktur naik turun, area luas, kondisi angin dan cuaca berubah-ubah, menyebabkan frekuensi intermiten meningkat, dan tonase berubah-ubah, yang berpengaruh pada fluktuasi konsumsi energi. Analisis regresi multivarian digunakan untuk menyelidiki variabel-variabel independen yang berpengaruh langsung terhadap konsumsi energi sistem konveyor, yaitu jumlah intermiten atau start-stop konveyor, durasi tonase, dan komposisi roller. Peningkatan performa pada variabel-variabel ini menghasilkan kesimpulan bahwa penambahan tiga teknisi terampil dapat meningkatkan kualitas preventive maintenance (PM) yang mengurangi breakdown fasilitas sebesar 80%, serta berpotensi menghemat energi hingga 33.184,26 kWH/bulan. Durasi tonase optimal per hari untuk meminimumkan konsumsi energi, namun tetap memenuhi kebutuhan batubara yang ditransportasikan sebesar 22.000 ton per hari adalah berturut-turut 0,30; 2,56; dan 13,30 jam pada tonase <1000, 1000-1200, dan 1200-1400 tph, berpotensi menghemat energi hingga 9.462,44 kWH/bulan. Sedangkan skenario penggantian roller berumur di atas dua tahun sebesar 2% dari total keseluruhan berpotensi menghemat energi hingga 16.997,44 kWH/bulan.
Higher Tate traces of Chow motives
Authors: De Clercq Charles , Quéguiner-Mathieu Anne 
Published: August 2024

AbstractWe establish the complete classification of Chow motives of projective homogeneous varieties forp-inner semi-simple algebraic groups, with coefficients inℤ/p⁢ℤ{{\mathbb{Z}}/p{\mathbb{Z}}}. Our results involve a new motivic invariant, the Tate trace of a motive, defined as a pure Tate summand of maximal rank. They apply more generally to objects of the Tate subcategory generated by upper motives of irreducible, geometrically split varieties satisfying the nilpotence principle. Using Chernousov–Gille–Merkurjev decompositions and their interpretation through Bialynicki–Birula–Hesselink–Iversen filtrations due to Brosnan, we then generalize the characterization of the motivic equivalence of inner semi-simple groups through the higher Titsp-indexes. We also define the motivic splitting pattern and the motivic splitting towers of a summand of the motive of a projective homogeneous variety, which correspond for quadrics to the classical splitting pattern and Knebusch tower of the underlying quadratic form.
Approximation of functions in H
⃗p

η1,η2
class by Fejér-type operators
Authors: Patel Yogeshkumar K. , Vyas Rajendra G. 
Published: August 2024

Abstract
In the present work, we explore Fejér-type operators within the mixed Lebesgue space

L

p
→

⁢

[

ℝ
2

]

{L_{\vec{p}}[\mathbb{R}^{2}]}

and establish the degree of approximation for functions belonging to the class

H

p
→

η
1

,

η
2

{H_{\vec{p}}^{\eta_{1},\eta_{2}}}

through the utilization of Fejér-type operators.
Time-antiperiodic and space-periodic boundary value problem for one class of semilinear partial differential equations
Authors: Kharibegashvili Sergo , Midodashvili Bidzina 
Published: August 2024

Abstract
In this work, a time-antiperiodic and space-periodic boundary value problem for one class of semilinear partial differential equations is studied. The theorems on existence, uniqueness and nonexistence of solutions of this problem are proved.
Lacunary weak convergence of sequences defined by Orlicz function
Authors: Tamuli Bibhajyoti , Tripathy Binod Chandra 
Published: August 2024

Abstract
In this article, we introduced the idea of lacunary weak convergence of sequences defined by the class of Orlicz function. Various topological and algebraic properties, such as solidity, symmetry, and monotonicity, have been studied. To validate the failure instances, we gave appropriate examples and detailed discussions. Additionally, we have established some inclusion relationships between these spaces.
Clausal agreement on adverbs in Andi
Authors: Kaye Steven 
Published: August 2024

Abstract
Andi (Nakh-Daghestanian; Russia) displays a typologically remarkable phenomenon: adverbs of numerous morphological and functional types inflect for agreement with a clause-level controller. To the extent that adverb agreement has been observed elsewhere, it is commonly taken to signal that the items involved are semantically oriented towards the participants they agree with, aligning the phenomenon with secondary predication. This paper demonstrates that Andi works differently: the widespread clausal agreement seen on Andi adverbs is insensitive to participant orientation. While agreement exponence on adverbs is morphologically complex, a simple structural principle (modelled here in Minimalist terms) ensures that clause-level agreement is always with the absolutive-case argument. The Andi facts thus provide evidence for a typological distinction between those languages where clausal agreement on adverbs can serve a semantic function and those where it cannot. A potential challenge is posed by the exceptional “biabsolutive” construction, where both subject and object appear in absolutive case and either may control adverb agreement, suggesting a role for some additional non-structural factor. However, on independent grounds this paper identifies the two arguments as belonging to distinct structural layers; this apparent flexibility in controller choice merely reflects the ability of certain adverbs to modify either layer.