bluuebunny/crossref_metadata_2025_split huggingface dataset:
TRIPLE FUNGAL INFECTION—CHRONIC MUCOCUTANEOUS CANDIDIASIS, EXOPHYTIC DERMATOPHYTOSIS AND CRYPTOCOCCAL MENINGITIS: A NEW AND UNUSUAL COMBINATION—
Authors: Matsumoto Tadahiko 
Published: April 2015

ABSTRACTThe clinical and immunological studies of an unusual case of chronic mucocutaneous candidiasis (CMCC) are reported. An 18‐year‐old male with life‐long CMCC was superinfected by a dermatophyte showing exophytic clinical features in his childhood. In addition he has suffered from fatal cryptococcal meningitis since the age of 18. The combination of three fungi, i.e., Candida albicans, Trichophyton mentagrophytes and Cryptococcus neoformans, has not been found in an examination of the literature.The author's hypothesis, “immune deviation theory” in the pathogenesis of CMCC, is presented in detail.The possible role of hypovitaminosis A and disorder of iron metabolism in CMCC and treatment of CMCC are reviewed briefly.
TREATMENT OF PUSTULOSIS PALMARIS ET PLANTARIS WITH LARGE DOSES OF VITAMIN B12
Authors: Miura Takashi , Torinuki Wakio , Makino Yoshio 
Published: April 2015

ABSTRACTThirty‐three patients with pustulosis palmaris et plantaris were treated with large doses of vitamin B12 (cyanocobalamin and/or coenzyme B12). Those patients receiving large doses for a long period of time showed a better response than those who received small doses for a shorter period.
CLINICAL STUDY OF ANTINUCLEAR ANTIBODY AND ITS RELATION TO CLINICAL COURSE
Authors: Deng Jau‐Shyong , Wu Ying‐Chin , Lü Yau‐Chin 
Published: April 2015

ABSTRACTIndirect immunofluorescent test was used to study the clinical significance of antinuclear antibodies (ANA) in 116 systemic lupus erythematosus (SLE) patients. It was found that ANA was present in 96.5% of SLE patients and that their presence could serve as an important laboratory characteristics. A titer of 160 or more could also serve as suggestive evidence for SLE. The chief morphological appearance of ANA was peripheral pattern and homogenous pattern. The peripheral pattern was associated with high titer. A change of titer and pattern were interrelated. A change from homogenous to peripheral pattern indicated a downhill course of the disease, and a change from peripheral to homogenous pattern showed clinical improvement of the disease.
CLINICAL COURSE OF ATROPHIE BLANCHE
Authors: Miura Takashi , Torinuki Wakio 
Published: April 2015

ABSTRACTLesions of atrophie blanche which developed in 2 patients with systemic lupus erythematosus have been followed up for 3 years. The observation was made that atrophie blanche was not always preceded by ulcers but healed directly as scars. It was assumed that atrophie blanche might not be a terminal stage of necrotizing angitis but an intermediate one in the healing process.
FREEZE‐ETCHING OBSERVATIONS OF Fonsecaea pedrosoi
Authors: Hasegawa Teruhiko , Takeuchi Makoto , Nakai Eiichi , Rajan V.S. 
Published: April 2015

ABSTRACTThe fine structure of Fonsecaea pedrosoi was studied by freeze‐etching techniques. The structure of the cell wall as seen in Trichophyton groups was not observed. The invaginations were clearly shown in the plasma membrane. Three‐dimensional views of the fine structure were presented.
A CASE OF CHROMOMYCOSIS TREATED WITH 5‐FLUOROCYTOSINE
Authors: Maruta Hiroyuki , Minami Kikuo 
Published: April 2015

ABSTRACTA 46‐year‐old housewife was treated orally with 5‐fluorocytosine (5‐FC). She was almost cured at 15 weeks after the administration. Under histological and electron microscopical examination, spores in the lesions were observed to be markedly decreased in number, and all of them had suffered a change of shape or had been destroyed. At the end of 33 weeks, however, the patient had a complete relapse.
IMMUNOHISTOCHEMICAL STUDY OF HUMAN XANTHOMA
Authors: Kodama Hajime , Masuda Tsutomu 
Published: April 2015

ABSTRACTSpecimens of human tuberous xanthomas obtained from two hyper‐β‐lipoproteinemic patients were prepared with HE and Sudan III stain and by direct immunofluorescence with fluorescein isothiocyanate labeled antihuman β‐lipoprotein rabbit serum. In some histiocytes and foam cells in early stages, lipids were stained in granular patterns and specific fluorescence was observed. In some foam cell nests, specific fluorescence was weak or absent, and orange‐colored lipid autofluorescence was present. The foam cells in such nests were probably late foam cells and corresponded to the large cytoplasmic foam cells stained densely and amorphously for lipids. It was concluded that at early stages of xanthoma formation, serum lipoproteins were incorporated into dermal histiocytes and early foam cells. The apoproteins of the incorporated lipoproteins were probably degraded and lipid residues accumulated in the cells. Specimens of tuberous xanthoma covered by plane xanthoma showed lipids and bright specific fluorescence at the basement membrane zone. A faint fluorescence was observed in the upper dermis and even in parts of the epidermal intercellular spaces.
PHENYLALANINE HYDROXYLASE DEFICIENCY IN THE PERIPHERAL LYMPHOCYTES FROM PHENYLKETONURIA
Authors: Yoshii Tamiko , Toda Kiyoshi , Kobori Tatsuji 
Published: April 2015

ABSTRACTA radiograph of the incorporation of 3H‐phenylalanine and 3H‐tyrosine into cultured lymphocytes in a phenylketonuria patient indicates phenylalanine hydroxylase deficiency in the peripheral lymphocytes.Cultured lymphocytes from the patient showed much less uptake of 3H‐phenylalanine and a slightly higher incorporation of 3H‐tyrosine than the control. It is possible that a lack of phenylalanine hydroxylase in the peripheral lymphocytes of PKU patients prevents oxidation of phenylalanine to tyrosine.
ORTHOPEDIC SYMPTOMS IN PUSTULAR BACTERID (PUSTULOSIS PALMARIS ET PLANTARIS): TIETZE'S SYNDROME AND ARTHRITIS OF MANUBRIOSTERNAL JOINT DUE TO FOCAL INFECTION
Authors: Ishibashi Akira , Nishiyama Yoshio , Endo Mikio , Kawaji Wataru , Kato Tadashi 
Published: April 2015

ABSTRACTPainful orthopedic symptoms in the sternal area, such as arthritis of the manubriosternal and sternoclavicular joint or Tietze's syndrome, were found in 14 of 132 cases of pustulosis palmaris et plantaris.The majority of the pustulosis palmaris et plantaris patients with orthopedic symptoms had skin eruptions not only on the palms and soles, but also on the backs of the hands and feet, the arms, the legs and the trunk. Such cases were usually accompanied by elevation of the erythrocyte sedimentation rate, leucocytosis, changes in serum globulin, and also pyrexia at the time of exacerbation.The skin and orthopedic symptoms often worsened after acute exacerbation of the focal infection, and occasionally responded to tonsillectomy or chemotherapy with antibiotics, which is suggestive of the probable cause of the bacterid.
XANTHOMA‐INDUCING β‐LIPOPROTEIN IMMUNE COMPLEXES
Authors: Kodama Hajime 
Published: April 2015

ABSTRACTUntreated rabbits and rabbits sensitized with human β‐lipoproteins were intracutaneously injected with either human or rabbit β‐lipoproteins (2 mg as protein). Forty‐eight hours later, at the human β‐lipoprotein injection site, dense cell infiltrations stood out sharply demarcated from the surrounding region. The infiltrating cells were composed of polymorphonuclear cells, nuclear dust and histiocytes. Foam cell nests were observed in sensitized rabbit dermis one week after human β‐lipoprotein injection. Direct immunofluorescence employing fluorescein isothiocyanate labeled antihuman β‐lipoprotein antiserum showed that the injected human β‐lipoproteins were incorporated into the infiltrating cells of sensitized rabbit dermis up to 48 hours after injection. Specific fluorescence was greatly reduced but lipid autofluorescence remained in mature foam cells. During the 3‐week examination period, no trace of foam cell nests was found at the site of human β‐lipoprotein injection on non‐sensitized rabbits. Intracutaneous rabbit β‐lipoprotein injection revealed no histiocytic infiltrations in either sensitized or non‐sensitized rabbits. These findings indicated that intracutaneously injected human β‐lipoporteins were incorporated into rabbit dermal histiocytes more easily in aggregated immune complex form than in their natural state. These histiocytes were easily transformed to foam cells. Apoproteins of the incorporated lipoproteins were degraded, and lipid residues accumulated in mature foam cells.
HELIOTHERAPY OF PITYRIASIS LICHENOIDES CHRONICA
Authors: Takada Yoshio , Irisawa Kaikichi , Kawada Akihiro 
Published: April 2015

ABSTRACTFifteen patients with pityriasis lichenoides chronica (parapsoriasis guttata) were treated with sunlight irradiation during the summer months at seaside resorts under the supervision of the authors. Complete clearing occurred in 1 of the patients, almost complete clearing in 8, definte improvement in 4, temporary clearing in 2. All patients responded beneficially and no worsening was noted in these 15 cases. In an additional six cases who were instructed to expose themselves to sunlight similar results were obtained.
ELECTRON MICROSCOPIC OBSERVATIONS ON THE LESIONS OF HERPES ZOSTER WITH TOPICAL APPLICATION OF INTERFERON
Authors: Uyeda Keiichi , Kagami Kiyoshi , Sotomatsu Shigetaro 
Published: April 2015

ABSTRACTThe lesions of herpes zoster in three patients were investigated electron microscopically before and after topical application of interferon.In the blister, on the 5th to 7th day after its formation, the following were seen: acantholytic cells with virus particles in the nucleus and cytoplasm, multinucleated cells derived from keratinocytes, edematous and degenerated keratinocytes containing virus particles and tonofibrillar materials, macrophages with many large vacuoles, neutrophils, lymphocytes and Langerhans's cells.After the first application of interferon, the findings for keratinocytes were the same as those of before application and keratinocytes were frequently found adjacent to macrophages. The macrophages were large and had numerons large vacuoles in the cytoplasm. After the second application of interferon, virus particles were often seen in the vacuoles of the macrophages in comparison with that before application. In the cytoplasm of macrophages, acantholytic keratinocytes and tonofibrillar materials were phagocytized. Many virus particles were seen in the vacuoles of some acantholytic keratinocytes.It was concluded from these findings that the macrophages accelerated the phagocytotic activity of the virus particles.
PITYRIASIS LICHENOIDES ET VARIOLIFORMIS ACUTA IMMUNOHISTOPATHOLOGIC STUDY*
Authors: Hayashi Tsutomu 
Published: April 2015

ABSTRACTImmunoglobulin M and complement (Clq, C3 and C9) were found to be deposited together in the walls of affected blood vessels and also in the basement membrane zone of skin lesions from two patients with pityriasis lichenoides et varioliformis acuta (PLVA). The fluorescence appeared to be most intensely distributed in blood vessels which were affected by inflammatory infiltrates and frequently showed hyaline or fibrinoid changes of their walls. Deposits of C3 activator, fibrin and albumin were not observed. These findings suggest that the disease process in PLVA is the result of a vasculitis mediated by an immune complex and possibly by activation of the classical complement pathway.In addition, serum IgM was slightly increased in both patients.
UNSPECIFIC INCREASE OF ANTISTREPTOLYSIN‐O TITER IN ACUTE GUTTATE PSORIASIS
Authors: Sato Hideya , Ishikawa Hidekazu 
Published: April 2015

ABSTRACTAn acute streptococcal infection is well‐known to be a predisposing factor in acute guttate psoriasis. This study also revealed a high ASO titer in 11 of 13 patients at first examination. However, a non‐specific ASO increase due to non‐immunological reaction of serum lipoproteins with antistreptolysin‐O, was found in 5 of these patients who visited our clinic at the evolving phase, 2 or 3 weeks after onset of the eruption but was no longer observed at 5–6 weeks and thereafter. On the other hand, specific ASO increase, which was not related to lipoproteins, was observed first in some patients at 3–4 weeks and at 7–10 weeks in all patients examined. These observations suggest the role of streptococcal lipoprotein alteration in the occurrence of this disease.
INACTIVATION OF T4 BACTERIOPHAGE BY NEAR ULTRAVIOLET LIGHT IN THE PRESENCE OF 8‐METHOXYPSORALEN
Authors: Suzuki Kenshi , Yanagisawa Fukuko , Fujita Hitoshi , Ohkido Muneo 
Published: April 2015

ABSTRACTThe killing action of near ultraviolet light emitted from a fluorescent black‐light lamp in the presence of 8‐methoxypsoralen was investigated using bacteriophage T4D and its mutants. It was found that a far ultraviolet‐sensitive mutant, T4v, was no more sensitive to the present photoreaction than the wild type. T4px and T4y were a little more sensitive than T4D. Contrary to the results of illumination with monochromatic light, exponential survival curves with pronounced shoulders were obtained. The reason for this finding is discussed on the basis of the mode of photoreaction.
THERMOGRAPHIC VENOGRAPHY
Authors: Kawatsu Tomoyuki , Miki Yoshiharu 
Published: April 2015

ABSTRACTThe superficial venous flow of the limb can be thermographically visualized when the distal portion of the limb is heated in a water bath.A total of 23 healthy adults and 116 adult patients with active or inactive venous occlusions and related diseases of the lower limb was examined by the thermographic venography. Abnormal thermovenograms included those with completely absent or delayed visulization, cessation or partial interruption, tortuosity or increased collateral flow, depending on the location and nature of the pathology.Thermographic venography can be used as a new diagnostic technique for screening before the radiation venography.
XANTHOMA FORMATION BY HUMAN β‐LIPOPROTEIN IMMUNE COMPLEXES IN RABBIT BLOOD STREAM
Authors: Kodama Hajime 
Published: April 2015

ABSTRACTTwo untreated rabbits and two rabbits sensitized with human β‐lipoproteins were intravenously injected with human β‐lipoproteins (20 mg as proteins) once a day for 18 days. One of the sensitized rabbits revealed three xanthomas along a yellow tendon of the left leg. Elevation of serum cholesterol level by the repeated injections was slight. Histologically, the xanthomas showed many foam cell nests around the vessels. Numerous polymorphonuclear cells and histiocytes were observed in the central area of these nests. Mature foam cells crowded the peripheral zone. In the intermediate zone, immature foam cells appeared. Immunohistochemical and lipid histochemical studies indicated the incorporation of human β‐lipoproteins into the histiocytes and immature foam cells. In the mature foam cells, however, apoproteins of human β‐lipoproteins had been degraded. The xanthomas apparently developed from the incorporation of extravasated human β‐lipoprotein immune complexes into dermal histiocytes. It is conceivable that human β‐lipoproteins were incorporated more easily in the aggregated immune complex form than in their natural form. Another possibility is that human β‐lipoproteins were more readily incorporated when they were rendered polycationic by complexing with immunoglobulins.
IMMUNOHISTOCHEMICAL AND ELECTRON MICROSCOPIC CHARACTERIZATION OF LYMPHOMATOID PAPULOSIS
Authors: Jimbow Kowichi , Kato Mihoko , Sugiyama Sadao 
Published: April 2015

ABSTRACTA case of a seven year old boy with lymphomatoid papulosis is presented in terms of (a) clinical and histopathological distinction from pityriasis lichenoides et varioliformis acuta (PLEVA), and (b) immunohistochemical and electron microscopic characterization of infiltrating cells in skin lesions. Our case showed recurrent episodes of high fever and skin eruptions similar to those seen in the ulceronecrotic form of PLEVA for three years. However, the case has been differentiated from PLEVA by showing (a) recurrent episodes of skin eruptions, (b) spontaneous remission of these eruptions, (c) presence of numerous eosinophils in the infiltrates, (d) dense aggregation of atypical lymphohistiocytic cells with the membrane marker of T‐lymphocytes, and (e) various, ultrastructural features similar to those seen in lymphoblastogenesis. Our immunohistochemical and electron microscopic studies suggest that the infiltrating cells in lymphomatoid papulosis are primarily derived from variants of T‐lymphocytes which are in the process of reactive lymphocytic hyperplasia.
FIBRINOLYTIC THERAPY FOR PROGRESSIVE SYSTEMIC SCLEROSIS AND TISSUE FIBRINOLYTIC ACTIVITY IN AFFECTED SKIN
Authors: Shigemi Fumio , Fujita Tomomichi , Ohsaki Masafumi , Shiraishi Satoshi 
Published: April 2015

ABSTRACTIn our present study, impairment of tissue fibrinolytic activity was observed in the affected skin of patients with progressive systemic sclerosis (PSS) by fibrinolytic autography. We treated PSS with a fibrinolytic agent, urokinase, based on the idea that the impairment of tissue fibrinolytic activity is implicated in the development of PSS. Two patients with PSS have responded favorably well to administration of Urokinase.
NEW ATTENDANTS AT THE OUT‐PATIENT CLINIC OF THE DEPARTMENT OF DERMATO‐VENEREOLOGY, Dr. CIPTO MANGUNKUSMO TEACHING AND GENERAL HOSPITAL, JAKARTA, 1976
Authors: Kosasih Achmad , Soebaryo Retno Widowati 
Published: April 2015

ABSTRACTThis paper has reported new cases of patients attending the out‐patient clinic of the Department of Dermato‐Venereology, Dr. Cipto Mangunkusumo Hospital, Jakarta, during the period of 1976. A total of 170 types of skin diseases have been diagnosed, among 13514 patients, and four kinds of venereal diseases among 344 patients.
A LIGHT AND ELECTRON MICROSCOPIC STUDY OF A CASE OF RADIATION INDUCED MALIGNANT GIANT CELL TUMOR OF THE SOFT TISSUE
Authors: Inada Shuichi , Yanai Shoko , Yamasaki Reiko , Numata Tsunemi , Jidoi Joji , Yamura Takuso , Egawa Hiromi 
Published: April 2015

ABSTRACTA case of malignant giant cell tumor of the soft tissue in a 59‐year‐old female is presented. Total hysterectomy was performed for uterine carcinoma (histologically squamous cell carcinoma) in 1963, followed by radiation treatment for 6 months. Chronic radiodermatitis developed thereafter on the skin of the hip joint region, buttocks and lower abdominal region. A tumor developed in the lesion of chronic radiodermatitis of the left hip joint region in August 1976 and this was excised on February 23, 1977. Two recurrent tumors and a metastatic lesion in the inguinal lymph node developed, which were surgically removed. The main tumor, measuring 7.5 cm in maximum diameter, was found chiefly in the subcutaneous adipose tissue. Histologically, it was composed of a mixture of fibroblastic spindle‐shaped cells, histiocytic mononuclear cells, bizarre giant cells and osteoclast‐like multinucleated giant cells. Occasionally osteoid tissues were seen. Electron microscopically, undifferentiated cells, fibroblastic cells, monohistiocytic cells, osteoclast like multinucleated giant cells and macrophages were observed, and these cells were considered to be divided into three cell lines, that is an undifferentiated cell line, fibroblastic cell line and histiocytic cell line.The histogenesis of malignant giant cell tumor in this case, is considered to have been from undifferentiated cells to both fibroblastic and histiocytic differentiation through the neoplastic stimulus of radiation.
INDUSTRIAL CONTACT DERMATITIS DUE TO NITRO AND AMINO DERIVATIVES
Authors: Naniwa Shiro 
Published: April 2015

ABSTRACTMass‐examination of all 31 employees of a chemical factory revealed that 20 of them were proved or suspected to have contact hypersensitivities to chemical substances used in the factory as follows: 12 cases were sensitive to 2‐amino‐4‐chlorophenol, 5 to para‐aminophenol, 2 to para‐dichloronitrobenzene, and 1 to para‐nitrophenol. Among the 5 compounds tested (including the above 4 substances and 3′‐chlorodiphenylamine‐2‐carboxylic acid), 2‐amino‐4‐chlorophenol was found to be an especially strong sensitizer.
AN EXPERIMENTAL MODEL OF XANTHOMA BY INTRADERMAL DEXTRAN SULFATE INJECTION
Authors: Kodama Hajime , Arakawa Kenzo , Nagao Yo , Tada Jyoji , Masuda Tsutomu , Nohara Nozomi 
Published: April 2015

ABSTRACTLarge molecular weight sodium dextran sulfate (SDS) injection into the dermis of both normolipemic rabbits and hypercholesterolemic rabbits induced infiltration of histiocytes and foam cells. Sudan III staining showed that the histiocytes and foam cells of hypercholesterolemic rabbits accumulated lipids similarly to xanthoma foam cells. The accumulated lipids increased as the injection was repeated at the same site. However, the lipid accumulation was minimal in the histiocytes of normolipemic rabbits. As determined by quantitative analysis of lipid composition in the lesions of hypercholesterolemic rabbits, cholesterol esters remarkably increased concomitantly with injection frequency. Free cholesterol accumulation was less pronounced than cholesterol ester. In normolipemic rabbit dermis, accumulation of free cholesterol was insignificant and cholesterol esters did not accumulate progressively with repeated SDS injections. Apparently the foam cells of hypercholesterolemic rabbits actively incorporated serum low density lipoproteins (LDL) and cholesterol was esterified in the foam cells. On the other hand, LDL were minimally incorporated into histiocytes in the normolipemic state. The intradermal SDS injection is a beneficial experimental model for further investigations on the mechanisms of lipid accumulation and the intracytoplasmic lipid metabolism of xanthoma foam cells.
CYCLIC AMP AND EPIDERMAL CELL DIVISION
Authors: Aso Kazuo , Kondo Shigeo , Amano Michiko 
Published: April 2015

ABSTRACTThe relationship of cyclic AMP to epidermal cell division has been studied in cultured guinea pig epidermal cells. Tritiated thymidine uptake by cultured cells reached a peak the second day after seeding. A significant drop in the concentration of cyclic AMP occurred simultaneously with the increased uptake of tritiated thymidine into DNA. Those cells in which the concentration of cyclic AMP decreased did not respond to external prostaglandin E1 (PGE1) stimulation. The response was restored in the cultured cells on the fourth and fifth when intracellular concentration of cyclic AMP started to rise. The results indicate that there is a cyclic alteration of the surface membrane of epidermal cells during active DNA synthesis which may be related to fluctuation in the intracellular concentration of cyclic AMP.
COMPARATIVE IMMUNOCHEMICAL STUDIES ON SPOROTHRIX SPECIES
Authors: Ishizaki Hiroshi , Nakamura Yoichi , Wheat Robert W. 
Published: April 2015

ABSTRACTSerological and chemical characteristics of eleven Sporothrix species were investigated by use of immunodiffusion precipitin reactions and gas liquid chromatography.The results presented in this study correspond with the morphological observations of Hoog, which indicated close similarities among S. schenckii, S. schenckii var. luriei, S. curviconia, and S. inflata. It is also suggested that in addition to the well known rhamnose determinants, mannose and/or galactose determinants also occur in Sporothrix schenckii antigens.
EFFECTS OF CYTOCHALASIN B ON HUMAN MALIGNANT
Authors: Kanzaki Tamotsu , Hashimoto Ken 
Published: April 2015

ABSTRACTHuman malignant melanoma cells and human squamous cell carcinoma cells were treated with cytochalasin B (CB) in vitro and observed with light and electron microscopes. When spindle‐shaped melanoma cells were treated with CB, they rounded up and their submembranous microfilaments (mf) (6 nanometers thick) vanished totally. After being released from CB after treatment for 10 days, they became flat and the submembranous mf reappeared to a nearly normal extent. Squamous cell carcinoma cells, when treated with CB, did not round up and the submembranous mf did not disappear.These results suggest that (i) submembranous microfilaments are not essential to make and keep certain types of cells round and (ii) the responses of cells to cytochalasin B are quite different in different cells.