bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systolic and diastolic impairment in cirrhotic cardiomyopathy: insights from a cross-sectional study
Authors: Mansoor Hala , Khizer Mahnam , Afreen Aneela , Sadiq Noor Masood , Habib Aamir , Ali Shafqat , Raza Asim , Hafeez Tayyaba 
Published: July 2024

Abstract
Background
Cirrhotic cardiomyopathy, an intricate and multifaceted complication of end-stage liver disease, manifests as systolic and diastolic dysfunction in patients without previously diagnosed cardiac disease. Our study aims to investigate the prevalence of systolic and diastolic function in patients with cirrhotic cardiomyopathy in our region.

Methods
We conducted a cross-sectional study on 68 patients with established cirrhosis, and no overt cardiac manifestations, who consequently underwent 2D echocardiography to quantify systolic and diastolic dysfunction, as defined by the 2019 Cirrhotic Cardiomyopathy Consortium. The severity of cirrhosis was determined using various validated scoring systems.

Results
A total of 19 out of 68 (28%) had systolic dysfunction, while 6/68 (9%) had evidence of diastolic dysfunction. Overall prevalence of cirrhotic cardiomyopathy was 23/68 (34%), and the presence of hepatitis C was strongly associated with systolic dysfunction with p-value of 0.007. However, it was not significantly associated with diastolic dysfunction, p-value = 0.59. Logistic regression analysis did not show any significant association between cardiac dysfunction and the severity of liver cirrhosis, as assessed by Child–Pugh, MELD, ALBI, PALBI, portal hypertension, and FIB-4 score (R2 = 3.66, F (13, 39) = 1.33, p = 0.234).

Conclusion
Our study reveals a remarkable prevalence of cirrhotic cardiomyopathy, which despite being a frequently occurring phenomenon often goes unrecognized. Lack of correlation with the severity of liver cirrhosis, based on currently available scoring system, suggests either a still poorly understood pathological mechanism or requires the development of a new validated reliable scoring system through multi-center longitudinal studies.
Significance of Measurable Residual Disease in Adult Philadelphia Chromosome–Positive ALL: A GRAAPH-2014 Study
Authors: Kim Rathana , Chalandon Yves , Rousselot Philippe , Cayuela Jean-Michel , Huguet Françoise , Balsat Marie , Passet Marie , Chevallier Patrice , Hicheri Yosr , Raffoux Emmanuel , Leguay Thibaut , Chantepie Sylvain , Maury Sébastien , Hayette Sandrine , Solly Françoise , Braun Thorsten , De Prijck Bernard , Cacheux Victoria , Salanoubat Celia , Farnault Laure , Guibaud Isabelle , Lamarque Mathilde , Gastaud Lauris , Lemasle Emilie , Brissot Eolia , Tavernier Emmanuelle , Bilger Karine , Villate Alban , Soulier Jean , Graux Carlos , Lhéritier Véronique , Dombret Hervé , Boissel Nicolas , Clappier Emmanuelle 
Published: July 2024

PURPOSE BCR::ABL1 quantification is widely regarded as the standard for monitoring measurable residual disease (MRD) in Philadelphia chromosome–positive (Ph+) ALL. However, recent evidence of BCR::ABL1 multilineage involvement questions the significance of BCR::ABL1 MRD. We aimed to define the prognostic role of MRD as assessed by BCR::ABL1 or lymphoid-specific immunoglobulin/T-cell receptor ( IG/TR) gene markers. PATIENTS AND METHODS We conducted BCR::ABL1 and IG/TR quantification after each treatment cycle in 264 patients treated in the GRAAPH-2014 trial, which used four cycles of reduced-intensity chemotherapy with nilotinib, followed by hematopoietic stem-cell transplantation (HSCT). RESULTS Comparing BCR::ABL1 and IG/TR MRD revealed residual BCR::ABL1-positive non-ALL cells in 98 (43%) of 228 patients, defining multilineage Ph+ ALL. Despite poorer BCR::ABL1 responses, patients with multilineage Ph+ ALL had similar disease-free survival (DFS; hazard ratio [HR], 0.83 [95% CI, 0.49 to 1.41]; P = .50). Although BCR::ABL1 response failed to predict outcomes, IG/TR positivity (≥0.01%) was strongly associated with lower DFS (after cycle 2, HR, 2.49 [95% CI, 1.40 to 4.40]; P = .002; after cycle 4, HR, 4.13 [95% CI, 1.82 to 9.38]; P = .001). In multivariable analysis, both IG/TR positivity after cycle 2 and initial WBC count ≥30 × 109/L predicted poorer DFS, enabling to define a high-risk group having a 4-year DFS of 56.5% compared with 87.6% (HR, 3.72 [95% CI, 1.93 to 7.15]; P < .001). Moreover, allogeneic HSCT significantly improved DFS in the high-risk group (HR, 0.33 [95% CI, 0.18 to 0.60]; P < .001), whereas the standard-risk group had favorable outcomes regardless of allogeneic HSCT. CONCLUSION Our findings challenge the significance of BCR::ABL1 monitoring in adult Ph+ ALL and demonstrate the prognostic role of IG/TR MRD. This study provides a framework for using MRD to guide treatment strategies in adults with Ph+ ALL.
Vaccinome Landscape in Nearly 620 000 Patients With Diabetes
Authors: D’Addio Francesca , Lazzaroni Elisa , Lunati Maria Elena , Preziosi Giuseppe , Ercolanoni Michele , Turola Giulio , Marrocu Chiara , Cicconi Giovanni , Sharma Sudwaric , Scarioni Simona , Montefusco Laura , Pastore Ida , Morpurgo Paola Silvia , Rossi Antonio , Gandolfi Alessandra , Tinari Camilla , Rossi Giada , Ben Nasr Moufida , Loretelli Cristian , Fiorina Roberta Maria , Grassa Baldassarre , Terranova Rosa , Bucciarelli Loredana , Berra Cesare , Cereda Danilo , Zuccotti Gianvincenzo , Borriello Catia Rosanna , Fiorina Paolo 
Published: July 2024

Abstract

Context
Type 1 (T1D) and type 2 diabetes (T2D) are associated with an elevated incidence of infectious diseases and a higher risk of infections-related hospitalization and death.

Objective
In this study, we delineated the “vaccinome” landscape obtained with a large immunization schedule offered by the Regional Government of Lombardy in a cohort of 618 396 patients with diabetes (T1D and T2D).

Methods
Between September 2021 and September 2022, immunization coverage for influenza, meningococcus, pneumococcus, and herpes zoster was obtained from the public computerized registry of the health care system of Lombardy Region (Italy) in 618 396 patients with diabetes and in 9 534 087 subjects without diabetes. Type of diabetes, age, mortality, and hospitalizations were retrospectively analyzed in vaccinated and unvaccinated patients.

Results
Among patients with diabetes (T1D and T2D), 44.6% received the influenza vaccine, 10.9% the pneumococcal vaccine, 2.5% the antimeningococcus vaccine, and 0.7% the antizoster vaccine. Patients with diabetes immunized for influenza, zoster, and meningococcus showed a 2-fold overall reduction in mortality risk and a decrease in hospitalizations. A 3-fold lower risk of mortality and a decrease in hospitalizations for both cardiac and pulmonary causes were also observed after influenza, zoster, and meningococcus immunization in older patients with diabetes.

Conclusion
Immunization coverage is still far from the recommended targets in patients with diabetes. Despite this, influenza vaccination protected nearly 3800 per 100 000 patients with diabetes from risk of death. The overall impressive decrease in mortality and hospitalizations observed in vaccinated patients strengthens the need for scaling up the “vaccinome” landscape in patients with diabetes.
Application of real-time shear wave elastography to Achilles tendon hardness evaluation in older adults
Authors: He Xuan , Wei Xin , Hou Jia , Tan Wei , Luo Ping 
Published: July 2024

BACKGROUND
Real-time shear wave elastography (SWE) is a non-invasive imaging technique used to measure tissue stiffness by generating and tracking shear waves in real time. This advanced ultrasound-based method provides quantitative information regarding tissue elasticity, offering valuable insights into the mechanical properties of biological tissues. However, the application of real-time SWE in the musculoskeletal system and sports medicine has not been extensively studied.
AIM
To explore the practical value of real-time SWE for assessing Achilles tendon hardness in older adults.
METHODS
A total of 60 participants were enrolled in the present study, and differences in the elastic moduli of the bilateral Achilles tendons were compared among the following categories: (1) Age: 55-60, 60-65, and 65-70-years-old; (2) Sex: Male and female; (3) Laterality: Left and right sides; (4) Tendon state: Relaxed and tense state; and (5) Tendon segment: Proximal, middle, and distal.
RESULTS
There were no significant differences in the elastic moduli of the bilateral Achilles tendons when comparing by age or sex (P > 0.05). There were, however, significant differences when comparing by tendon side, state, or segment (P < 0.05).
CONCLUSION
Real-time SWE plays a significant role compared to other examination methods in the evaluation of Achilles tendon hardness in older adults.
Occupational hazards and risks among the women in fisher communities in Cox’s Bazar and Chattogram, Bangladesh
Authors: Halder Charls Erik , Das Partha Pratim , Rahman S. M. Tareq , Bhoumick Liton Chandra , Tassdik Hamim , Hasan Md. Abeed , Mithun Sourav Nath 
Published: July 2024

Background
Women in the fisher communities in coastal regions of Bangladesh are engaged in a wide range of fishery activities. However, there is limited evidence available on the occupational hazards and risks experienced by them.

Method
The study was conducted among fishing colonies in Cox’s Bazar and Chattogram districts in Bangladesh. This was a cross-sectional study blending qualitative and quantitative approaches. The qualitative component comprised five focus group discussions to understand the occupational context, hazards, and risks faced by the fisherwomen, informing the questionnaire design for the subsequent survey. The quantitative survey involved a sample of 207 women from fisher communities, gathering socio-demographic information, occupational hazards, risks, and health and safety practices.

Findings
The study found a high occurrence of occupational hazards, health risks and limited availability of preventive measures among the women in fisher communities. Occupational hazards include physical safety hazards such as slippery surfaces and fish cutting instruments, and physical hazards like prolonged sun exposure and noise. Chemical hazards like pesticides and saltwater, ergonomic hazards such as prolonged uncomfortable posture and heavy lifting, and biological hazards including inadequate sanitation facilities were prevalent. The study also identified the potential occupational risks, and the outcomes resulting from the hazards, including injuries (87.44%), musculoskeletal conditions (69.08%), skin diseases/conditions (56.52%), eye complaints (33.82%), severe respiratory distress (24.15%) and high incidence of self-reported communicable diseases. Most women (78.26%) did not use personal protective equipment, and the majority (93.72%) lacked a workplace first aid kit.

Conclusion
The study revealed a high prevalence of occupational hazards and health risks, including injuries and diseases, among Bangladeshi women in fisher communities with insufficient safety measures. Collaboration among government, NGOs, development partners, fisheries stakeholders, and the community is imperative for targeted training, innovative procedures, ergonomic solutions, provision of protective equipment, and advocacy to enhance the well-being of these women.
Longitudinal impact of screening colonoscopy on greenhouse gas emissions
Authors: Yusuf Hasiya , Gupta Vinita , Osaghae Ikponmwosa , Kumar Abhishek 
Published: July 2024

Background and aim
Colonoscopy is the gold-standard screening test for colorectal cancer. However, it has come under scrutiny for its carbon footprint and contribution to greenhouse gas (GHG) emissions compared to other medical procedures. Notwithstanding, screening colonoscopies may have a positive effect on GHG emissions that is unknown. This study estimated the carbon emissions prevented by screening colonoscopies in the U.S.

Methods
Using the reported number of screening colonoscopies performed annually in the U.S. and the absolute risk reduction (ARR) reported in the NorDICC trial, we calculated the expected minimum number of cancer treatment and surveillance visits prevented through screening based on the cancer stage. The average carbon emission averted per mile traveled was computed using the Environmental Protection Agency’s (EPA) GHG equivalencies calculator. The final estimate of carbon emissions averted over a decade by screening colonoscopies performed in one year was determined.

Result
6.3 million screening colonoscopies performed in one year prevent 1,134,000 colorectal cancers over a ten-year period. Of these, 38∙3% (434,254) are localized, 38∙8% (440,281) are regional, and 22∙9% (259,465) are metastatic disease. The minimum number of post-diagnosis visits prevented is 11 for stage I, ≥ 21 for stage II, ≥25 for stage III, and ≥ 20 for stage IV disease, comprised of diagnostic, surgical evaluation, chemotherapy, and surveillance visits. The total number of visits prevented by screening is 2,388,397 for stage I, 5,254,421 for stage II, 13,120,369 for stage III, and 9,210,972 for stage IV disease. Approximately 395 million miles of travel and 158,263 metric tons of CO2, equivalent to 177 million pounds of coal burned, 19 billion smartphones charged, or 18 million gallons of gasoline consumed, were saved over ten years through screening.

Conclusion
Colorectal cancer screening decreases cancer-related GHG emissions and minimizes the environmental impact of cancer treatment.
Association of dietary diversity and quality with cognitive performance and odds of Alzheimer's disease: A cross-sectional study.
Authors: Kheirouri Sorayya , Azizi Armin , Valiei Fatemeh , Taheraghdam Ali-Akbar 
Published: July 2024

Introduction: Scientific evidence proposes that a healthy and diverse diet may have a role in preserving brain and cognitive performance. We sought to investigate the association of dietary diversity and quality with cognitive performance and odds of Alzheimer's disease (AD).
Methods: This cross-sectional study was undertaken on 89 participants (60 Alzheimer's patients and 29 healthy individuals) over 60 years old (38 men and 51 women). A three-day food record was used to assess the dietary intake of participants. The dietary diversity (DD) score was examined using guidelines by the FAO (Food and Agriculture Organization), and diet quality was assessed using the healthy eating index (HEI) and dietary quality index (DQI). Cognitive performance was appraised via the Mini-Mental State Test (MMSE).
Results: The DD score was significantly lower in the AD group than in the healthy group (p<0.001). However, there was no significant difference in HEI and DQI scores between AD and healthy groups (p>0.05). There was a significant association between DD score with total MMSE score (β= 0.33, p=0.02), memory (β=0.35, p=0.02), and language (β= 0.32, p=0.03). HEI was positively correlated with calculation (β= 0.32, p=0.02). A high DD reduced the odds of AD by 79% (OR: 0.21; 95% CI: 0.10, 0.42; p<0.001) in a multivariate model.
Conclusions: A high DD may be associated with improved cognitive status and may reduce the odds of AD.
Funding: Tabriz University of Medical Sciences.
Isomangiferin promotes the migration and osteogenic differentiation of rat bone marrow mesenchymal stem cells
Authors: Gao Bingjun , Cheng Xin , Wu Yarong , Jiang Boyi 
Published: July 2024

Abstract
Delayed or failed bone healing is a significant clinical challenge worldwide. Bone marrow mesenchymal stem cells (BMSCs) offer a promising approach for improving fracture healing. Isomangiferin, a xanthone C-glucoside, is known for its pharmacological activities, but its role in fracture healing remains unclear. In this study, we investigated the effects of isomangiferin on BMSCs under oxidative stress conditions induced by hydrogen peroxide (H2O2). Our results showed that isomangiferin promotes osteogenic differentiation and migration of H2O2-treated BMSCs, reduces apoptosis and reactive oxygen species production, and activates the AMP-activated protein kinase/acetyl-CoA carboxylase (AMPK/ACC) pathway. These findings suggest that isomangiferin may be a potential therapeutic agent for enhancing bone healing by modulating BMSC function.
Curcumin conjugated zinc nanoparticles for the treatment of myocardial infarction
Authors: Tan Lijuan 
Published: July 2024

Abstract
A modern cardioprotective drug was created by utilizing zinc nanoparticles (ZnNPs) containing curcumin to address isoproterenol-induced myocardial infarction in mice, with a specific focus on the PPAR-γ/NF-κB pathway. During the in vivo study, mice were subjected to myocardial infarction by subcutaneously administering isoproterenol at a dosage of 40 mg/kg every 12 h for a total of three administrations. The mice were randomly divided into five groups: (I, II) isoproterenol + ZnNPs at different concentrations (10, 40 μg/mL) and time intervals, (III) isoproterenol alone, and (IV) control group. Various physicochemical methods, including FT-IR, field emission scanning electron microscopy, X-Ray diffraction analysis, fourier-transform infrared spectroscopy and energy dispersive X-ray spectroscopy, were utilized to analyze and characterize the ZnNPs. The real-time PCR and western blot methods were used to examine the PPAR-γ/NF-κB activation by lipopolysaccharide (LPS) and the subsequent cytokine release. This research focused on investigating the inflammatory responses and cell apoptosis in human coronary artery endothelial cells treated with LPS. After the therapy, cardiac function was checked using an electrocardiogram, along with biochemical and histochemical analysis. The introduction of ZnNPs leads to a decrease in the inflammatory conditions present in the hearts of mice suffering from myocardial infarction. The use of ZnNPs not only enhances ventricular wall infarction but also reduces mortality rates and suppresses levels of myocardial injury markers. The usual ST segment depression observed in mice with myocardial infarction is markedly reduced when treated with ZnNPs. The mice with myocardial infarction in the pre + post-isoproterenol group seemed to experience more pronounced cardioprotective effects from the treatment with ZnNPs compared to those in the post-isoproterenol group. In an in vitro experiment, the use of ZnNPs resulted in a significant reduction in cell death and inhibition of inflammation cytokine expression. The gene expression normalization for PPAR-γ/NF-κB/IκB-α/IKKα/β and the phosphorylation of PPAR-γ could potentially be associated with the beneficial effects of ZnNPs. The rise in inflammatory responses was effectively prevented. The results of this study indicate that ZnNPs have cardioprotective efficacies on isoproterenol-induced myocardial infarction. This positive impact could be linked to the PPAR-γ activation and the NF-κB signaling inhibition.
Translation Competence in Translator Training Programs at Saudi Universities: Empirical Study
Authors: Hazaea Abduljalil Nasr , Qassem Mutahar 
Published: July 2024

Abstract
This study aims to investigate the manifestations of instrumental translation competence (ITC) in translator training programs in six Saudi universities. It explores students’ knowledge and skills in ITC in terms of training and translation courses, translation tools, and usage patterns, drawing on the PACTE group of translation competence. In this empirical study, the data were collected from the documents of program and course specifications at translation programs in six Saudi universities, utilizing a checklist to analyze the manifestations of ITC in the targeted programs. Further, an open-ended questionnaire was utilized to identify translation students’ perceptions of ITC in such programs. While the open questions were analyzed using thematic analysis, the closed questions were analyzed quantitatively. The study found that the translation training programs include translation technology courses, albeit to a lesser extent, including only one or two translation technology courses within the entire 4-year program. The main emerging themes from the students’ responses are enhancement, level of experience, and utilization of ITC. The analysis also revealed a lack of training in translation technology, a lack of knowledge of advanced translation tools, their awareness of the impact of translation tools on translation quality, and inappropriate use of translation tools.
Analysis of initial core and time dependent fuel burnup for high temperature testing reactors (HTTRs)
Authors: Aziz Moustafa 
Published: July 2024

Abstract
HTTRs are high temperature testing reactors which are considered generation IV nuclear power reactors. The reactor core startup and fuel burnup time dependent are simulated and analyzed. For the present computer model core startup, fuel loading with approach to criticality, control rod critical positions, scram reactivity and control rod worth, different core excess reactivity are evaluated. The results are compared with both typical measurements and other previously published methods. Moreover, the time dependent core model and fuel burn up are simulated to calculate the core multiplication factor, cycle length, discharged burnup, core isotopic evolution with time and burnable poisons behavior.
Harmony in diversity: exploring cross-linguistic, cross-cultural and multimodal dimensions of temporality within tourism discourse
Authors: Messner Monika 
Published: July 2024

Abstract
This study explores temporal aspects in tourism discourse across modes, languages and cultures, focusing on translated texts in German, Italian, French, English, and Spanish. Tourism communication, a persuasive force promoting destinations, constructs authentic experiences for potential tourists. Beyond promotion, it reflects a societal practice shaping tourist identities and destination cultures. The translation of tourism texts involves considerations of cultural values and multimodal representations, seeking to transfer the unique selling proposition effectively. Existing research has analyzed trigger words, interlingual strategies, and cultural representations, but a gap exists in understanding the translation of temporal aspects. This paper investigates the multimodal representation, promotion, and transfer of temporality in tourism texts, contributing to contrastive and multimodal research in tourism communication. Key questions addressed include how elements from different modes contribute to the unique selling proposition, how the advertising message is conveyed in a multimodal coherent way, and which temporal aspects are translated and adapted in the target language. The present paper sheds light on the intricate interplay of language and image in conveying the temporal dimension of tourist experiences across diverse linguistic and cultural contexts.
Coherent manipulation of bright and dark solitons of reflection and transmission pulses through sodium atomic medium
Authors: Abdeljawad Thabet , Al-Jaser Asma , Abdalla Bahaaeldin , Shah Kamal , Hleili Manel , Alqudah Manar 
Published: July 2024

Abstract
The coherent manipulation and control of bright and dark solitons through sodium atomic medium have been investigated in this manuscript. Dark soliton is reported for reflection and bright soliton is reported for transmission pulses with variation in position and driving field parameters through sodium atomic medium. Further the transmission pulse is periodic dark and bright solitonic behaviors and reflection pulse is periodic bright solitonic behavior with variation in the incident angle and Rabi frequency of the control field. Elliptical dark and bright solitons as well as breather types solitons are also investigated for reflection and transmission pulses. The dark soliton in reflection is due to slow light propagation and bright soliton is obtained due to fast light propagation of transmission through the medium. The modified results of the dark and bright solitons are useful for telecommunication and ultra-fast signal routing system.