bluuebunny/crossref_metadata_2025_split huggingface dataset:
AN OVERNIGHT SENSATION: HOW THE ACUTE INTRODUCTION OF A SHORT-STAY PATHWAY CAN BENEFIT A PREVIOUSLY COMPROMISED NHS ARTHROPLASTY SERVICE
Authors: Ilo K. , Van Duren B. H. , Higgins M. A. , Manktelow A. R. J. , Bloch B. V. 
Published: August 2024

We report the impact of implementing a new short-stay hip and knee arthroplasty pathway in a National Health Service (NHS) hospital. This was enacted due to existing concerns with a long length of stay (LOS) and reduced elective operating capacity each winter due to emergency bed pressures. The overnight introduction of this pathway was aimed to reduce LOS, alleviate bed pressures, minimise readmission rates and generate financial savings, all combining to facilitate full elective activity during the winter.We conducted a prospective study at a regional tertiary arthroplasty centre. The new pathway was introduced across the service overnight. It includes rigorous preoperative optimisation, specific anaesthetic protocols and uniform changes in surgical practice to allow a focus on early mobilization and discharge on the day of surgery where possible.Data collection spanned 17 months, including the initial six months post implementation of the short-stay pathway. LOS data was collected for the full period and data was compared pre- and post-implementation of the new pathway. Patient satisfaction and 30-day readmission data were also collected.There was an immediate and significant decrease in median LOS from 4 days pre-implementation to 1 day post-implementation. Patient satisfaction was high, and the 30-day readmission rate was unchanged (5.95%), with no readmissions directly related to decreased inpatient stay. Financial analyses revealed substantial cost savings due to reduced LOS and the elimination of routine post-operative blood tests, estimated at over £1.6m per year. Elective activity over winter was significantly higher (79%) than in the same time period in the previous year.An acute introduction of a carefully planned and coordinated short-stay hip and knee pathway is safe, cost-effective and popular with patients, but also contributes to increased efficiency in the delivery of elective healthcare in the context of increasing demand and financial constraints in the NHS.
Real-time optical-wireless cooperative switching on wireless quality degradation for end-to-end video delay guarantee
Authors: Ujikawa Hirotaka , Okamoto Yuka , Harada Takumi , Shimada Tatsuya , Yoshida Tomoaki 
Published: August 2024

This paper proposes an optical-wireless cooperative control method to guarantee end-to-end delays in the case of radio quality degradation in wireless networks by switching optical paths. The method leverages the control information from mobile systems to dynamically switch the optical path between the distributed unit (DU) and the far aggregated central unit (CU) to another path forward to the nearest virtualized central unit (vCU) at the edge sight, on the basis of the radio quality. This enables demanding applications that require a combination of high bandwidth and low latency, such as remote operation using drones. Preliminary simulations were conducted to investigate the effect of quality degradation in the wireless domain and the potential effectiveness of the proposed delay compensation method. In the experiments conducted to verify the feasibility of the proposed method, the results demonstrated that the optical path switching was successfully performed without packet loss and within 4 ms from the transmission of the control frame. The proposed method was also able to correctly switch back when the processing rate of mobile edge computing (MEC) was exceeded after the radio quality recovered. This study demonstrates the effectiveness of further coordination between wired and wireless control for a wider range of real-time applications using video.
Physics-aware cross-domain fusion aids learning-driven computer-generated holography
Authors: Yuan Ganzhangqin , Zhou Mi , Liu Fei , Chen Mu Ku , Jiang Kui , Peng Yifan , Geng Zihan 
Published: August 2024

The rapid advancement of computer-generated holography has bridged deep learning with traditional optical principles in recent years. However, a critical challenge in this evolution is the efficient and accurate conversion from the amplitude to phase domain for high-quality phase-only hologram (POH) generation. Existing computational models often struggle to address the inherent complexities of optical phenomena, compromising the conversion process. In this study, we present the cross-domain fusion network (CDFN), an architecture designed to tackle the complexities involved in POH generation. The CDFN employs a multi-stage (MS) mechanism to progressively learn the translation from amplitude to phase domain, complemented by the deep supervision (DS) strategy of middle features to enhance task-relevant feature learning from the initial stages. Additionally, we propose an infinite phase mapper (IPM), a phase-mapping function that circumvents the limitations of conventional activation functions and encapsulates the physical essence of holography. Through simulations, our proposed method successfully reconstructs high-quality 2K color images from the DIV2K dataset, achieving an average PSNR of 31.68 dB and SSIM of 0.944. Furthermore, we realize high-quality color image reconstruction in optical experiments. The experimental results highlight the computational intelligence and optical fidelity achieved by our proposed physics-aware cross-domain fusion.
Non-pharmaceutical interventions and epigenetic aging in adults: Protocol for a scoping review
Authors: Liebich Alina , Zheng Shenglin , Schachner Theresa , Mair Jacqueline , Jovanova Mia , Müller-Riemenschneider Falk , Kowatsch Tobias 
Published: August 2024

Introduction
Aging is the strongest risk factor for most chronic diseases. The rising burden of an aging population and non-communicable diseases (NCDs), contributes to escalating costs for society. Several non-pharmaceutical interventions can lower the risk of NCDs, including common mental disorders (CMDs), and may slow down biological aging, as evidenced by outcome markers such as epigenetic clocks. However, a comprehensive overview of whether and which non-pharmaceutical interventions may impact human epigenetic aging is missing. Synthesizing evidence of interventions on epigenetic aging that can be adopted by a wider population is key to guide healthy aging initiatives and to reduce the burden of NCDs and CMDs. This scoping review will identify and assess non-pharmaceutical interventions aimed to slow down epigenetic aging, including their intervention components, and the mode used for intervention delivery.

Methods and analysis
This protocol will include single- and multicomponent intervention studies that target individuals ≥ 18 years of age and use epigenetic clocks as primary or secondary outcomes. Five electronic databases will be searched for studies between July 2011 until December 2023. The final search will include the search terms adults, non-pharmaceutical interventions, epigenetic aging and their respective synonyms. We will include randomized controlled trials, non-randomized controlled studies, cohort studies, and case-control studies. Additionally, the reference list of other reviews will be screened for relevant articles. Study selection is carried out based on the defined eligibility criteria by two authors. Quality and risk of bias for the included studies will be assessed using the Critical Appraisal Skills Programme (CASP) checklist. Data extraction will include generic key information such as the research question and results, the intervention components, and specific epigenetic outcome measures used. Further data regarding the delivery mode of the treatment protocol will be collected.

Ethics and dissemination
This scoping review will summarize the characteristics of non-pharmaceutical intervention studies on epigenetic aging. This review will be the first step to formally identify key intervention components and delivery modes to guide future research on healthy aging interventions. The results will be disseminated through a peer-reviewed publication and presented at relevant conferences. This review will synthesize information from available publications and does not require further ethical approval.

Registration details
Open Science Framework https://doi.org/10.17605/OSF.IO/FEHNB.
Micro-osteoperforation for enhancement of orthodontic movement: A mechanical analysis using the finite element method
Authors: Gomes João Ricardo Cancian Lagomarcino , Vargas Ivana Ardenghi , Rodrigues Antônio Flávio Aires , Gertz Luiz Carlos , Freitas Maria Perpétua , Miguens Sergio Augusto Quevedo , Ozkomur Ahmet , Hernandez Pedro Antonio González 
Published: August 2024

Background
Micro-osteoperforation is a minimally invasive technique aimed at accelerating tooth movement. The goal of this novel experimental study was to assess tooth movement and stress distribution produced by the force of orthodontic movement on the tooth structure, periodontal ligament, and maxillary bone structure, with and without micro-osteoperforation, using the finite element method.

Materials and methods
Cone-beam computed tomography was used to obtain a virtual model of the maxilla and simulate the extraction of right and left first premolars. Three micro-osteoperforations (1.5 x 5 mm) were made in the hemiarch on the distal and mesial surfaces of upper canines, according to the power tip geometry of the Propel device (Propel Orthodontics, Ossining, New York, USA). An isotropic model of the maxilla was fabricated according to the finite element method by insertion of mechanical properties of the tooth structures, with orthodontic force (1.5 N) simulation in the distal movement on the upper canine of a hemiarch.

Results
Initial movement was larger when micro-osteoperforations were performed on the dental crown (24%) and on the periodontal ligament (29%). In addition, stress distribution was higher on the bone structure (31%) when micro-osteoperforations were used.

Conclusions
Micro-osteoperforations considerably increased the movement of both the dental crown and periodontal ligament, which highlights their importance in the improvement of orthodontic movement, as well as in stress distribution across the bone structure. Important stress absorption regions were identified within micro-osteoperforations.
Comparison of adult versus elderly patients with abdominal trauma: A retrospective database analysis
Authors: Dash Jeremy , Andereggen Elisabeth , Bentellis Imad , Massalou Damien 
Published: August 2024

Background
The growing geriatric population has specific medical characteristics that should be taken into account especially in trauma setting. There is little evidence on management of abdominal trauma in the elderly and this article compares the management and outcomes of younger and older patients in order to highlight fields of improvement.

Method
We conducted a retrospective database analysis from two European university hospitals selecting patients admitted for abdominal injury and extracted the following data: epidemiological data, mechanisms of the trauma, vital signs, blood tests, injuries, applied treatments, trauma scores and outcomes. We compared to different age group (16–64 and 65+ years old) using uni- and multivariable analysis.

Results
1181 patients were included for statistical analysis. The main mechanisms of injury in both group were traffic accidents and in the elderly group, falls were more frequent. Both had similar Abbreviated Injury Score except for the thoracic injuries, which was higher in the elderly group. We reported a death rate of 13% in the elderly group and 7% in the younger group. However, multivariable analysis did not report age as an independent predictor of mortality. The management including surgery, blood transfusion and need for intensive care were similar in both groups.

Conclusion
Although elderly patients suffering abdominal trauma have an almost two fold higher mortality, their management is quite similar leading to an important point of improvement in regards to triage and lower threshold for more aggressive management and surveillance. Age itself does not seem to be a reliable predictor of mortality. Introducing a frailty score when taking care of elderly trauma patients could improve the outcomes.
Intravenous Lidocaine for Refractory Pain in Patients With Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis: A Multicenter Prospective Nonrandomized Pilot Study
Authors: Augustinus Simone , Bieze Matthanja , Van Veldhuisen Charlotte L. , Boermeester Marja A. , Bonsing Bert A. , Bouwense Stefan A.W. , Bruno Marco J. , Busch Olivier R. , Ten Hoope Werner , Kallewaard Jan-Willem , van Kranen Henk J. , Niesters Marieke , Schellekens Niels C.J. , Steegers Monique A.H. , Voermans Rogier P. , de Vos-Geelen Judith , Wilmink Johanna W. , Van Zundert Jan H.M. , van Eijck Casper H. , Besselink Marc G. , Hollmann Markus W. ,   for the Dutch Pancreatic Cancer Group,   the Dutch Pancreatitis Study Group
Published: August 2024

INTRODUCTION:
Refractory pain is a major clinical problem in patients with pancreatic ductal adenocarcinoma (PDAC) and chronic pancreatitis (CP). New, effective therapies to reduce pain are urgently needed. Intravenous lidocaine is used in clinical practice in patients with PDAC and CP, but its efficacy has not been studied prospectively.

METHODS:
Multicenter prospective nonrandomized pilot study included patients with moderate or severe pain (Numeric Rating Scale ≥ 4) associated with PDAC or CP in 5 Dutch centers. An intravenous lidocaine bolus of 1.5 mg/kg was followed by continuous infusion at 1.5 mg/kg/hr. The dose was raised every 15 minutes until treatment response (up to a maximum 2 mg/kg/hr) and consecutively administered for 2 hours. Primary outcome was the mean difference in pain severity, preinfusion, and the first day after (Brief Pain Inventory [BPI] scale 1–10). A BPI decrease ≥1.3 points was considered clinically relevant.

RESULTS:
Overall, 30 patients were included, 19 with PDAC (63%) and 11 with CP (37%). The mean difference in BPI at day 1 was 1.1 (SD ± 1.3) points for patients with PDAC and 0.5 (SD ± 1.7) for patients with CP. A clinically relevant decrease in BPI on day 1 was reported in 9 of 29 patients (31%), and this response lasted up to 1 month. No serious complications were reported, and only 3 minor complications (vertigo, nausea, and tingling of mouth). Treatment with lidocaine did not impact quality of life.

DISCUSSION:
Intravenous lidocaine in patients with painful PDAC and CP did not show an overall clinically relevant reduction of pain. However, this pilot study shows that the treatment is feasible in this patient group and had a positive effect in a third of patients which lasted up to a month with only minor side effects. To prove or exclude the efficacy of intravenous lidocaine, the study should be performed in a study with a greater sample size and less heterogeneous patient group.
Über Erfüllung
Authors: Klein Martin , Schmidt Philipp 
Published: August 2024

Abstract
In his 1956 book Das Gemüt, Stephan Strasser presents an original phenomenological investigation into human happiness and pleasure. We will examine Strasser’s theory of happiness in more detail and reveal how he incorporates important phenomenological insights from Thomas Aquinas’ theory of the passions of the soul. Both Strasser and Aquinas view happiness as the fulfilment of intentional striving and differentiate between various feelings associated with the pursuit and attainment of a goal, such as joy and pleasure. However, while Aquinas believes that only an imperfect form of happiness can be attained in this life, Strasser aims to determine the essence of the highest form of happiness possible for human beings as the felt anticipation of perfect happiness in the future. Strasser, therefore, interprets Aquinas’ theory through the lens of an existential-phenomenological approach.
Innovative approaches to enhancing crack repair: Performance optimization of biopolymer-infused CXT
Authors: Asvitha Valli Sankaranarayanan , Ravi Kumar Muthuswamy Saraswathi 
Published: August 2024

Abstract
Biopolymer-modified cementitious repair material (CXT) is a composite material designed to enhance the properties of traditional cementitious materials through the incorporation of biopolymers. CXT is formed by blending cement (C) with biopolymers such as xanthan gum (XG) and additives like tartaric acid (TA), which improve the material’s performance characteristics. This study investigates the effects of varying dosages of XG, TA contents, and curing durations on the performance characteristics of CXT. We evaluated key performance indicators, including the flowability, workability, setting time, compressive strength, and shrinkage. The optimal formulation XG 1:2 TA0.6 achieved a maximum compressive strength of 25 N·mm−² and a flexural strength of 9.4 N·mm−², with negligible shrinkage. The results showed rapid early strength development, with the material reaching over 77% of its final compressive strength within the first 14 days. These findings highlight the potential of CXT for crack-repair applications, offering improved workability, accelerated setting times, and reduced environmental impact compared to traditional repair materials. This study provides valuable insights for optimizing the formulation of CXT for enhanced performance in real-world applications.
Bioremediation of p-nitrophenol using an indigenous algal strain Tetradesmus sp. NITD18: a sustainable approach
Authors: Kandar Bulti , Rai Abhilasha , Dutta Susmita , Ghanta Kartik Chandra 
Published: August 2024

Abstract
The present study assessed the capability of Tetradesmus sp. NITD18, a green algal strain collected from the run-off water of a gas producing industry at Durgapur, for removing p-nitrophenol (PNP) from synthetic wastewater. The maximum removal efficiency of 59.64 ± 0.30 % was observed at an initial PNP concentration of 5 mg/L, initial pH 7, inoculum size of 15 % (v/v), and an incubation period of 15 days. The effect of pH (7–12) and inoculum sizes (5–15 %) on the removal of PNP using the test strain was assessed by varying these parameters judiciously. The results suggested that the Tetradesmus sp. NITD18 strain has considerable potential for PNP removal from wastewater.
Management of subepithelial esophageal tumors
Authors: Schneider Marcel A. , Vetter Diana , Gutschow Christian A. 
Published: August 2024

Abstract
Subepithelial esophageal tumors (SET) are normally benign intramural esophageal lesions of mesenchymal origin. Although rare, the incidence of SET has increased in recent decades due to the more widespread use of endoscopy and diagnostic imaging. The current review aims to provide an overview of the histopathologic spectrum and the most frequent entities including leiomyoma and gastrointestinal stromal tumor (GIST), diagnostic workup, and multidisciplinary treatment options. Staging for SET should include endoscopy, endoscopic ultrasonography (EUS), and tissue sampling. Current consensus guidelines recommend that SET suggestive of gastrointestinal stromal tumor (GIST) larger than 20 mm or lesions with high-risk stigmata should undergo tissue sampling. Most SET have an excellent long-term outcome, but malignancy may be present in certain subtypes. Asymptomatic SET without high-risk stigmata discovered incidentally usually do not require specific treatment. However, depending on the size and location of the lesion symptoms may occur. Therapeutic interventions range from endoscopic interventional resections to major surgical procedures. Enucleation via minimally invasive or robotic-assisted access remains the standard of care for most SET sub-entities.
Deep learning for automated boundary detection and segmentation in organ donation photography
Authors: Kourounis Georgios , Elmahmudi Ali Ahmed , Thomson Brian , Nandi Robin , Tingle Samuel J. , Glover Emily K. , Thompson Emily , Mahendran Balaji , Connelly Chloe , Gibson Beth , Bates Lucy , Sheerin Neil S. , Hunter James , Ugail Hassan , Wilson Colin 
Published: August 2024

Abstract

Objectives
Medical photography is ubiquitous and plays an increasingly important role in the fields of medicine and surgery. Any assessment of these photographs by computer vision algorithms requires first that the area of interest can accurately be delineated from the background. We aimed to develop deep learning segmentation models for kidney and liver organ donation photographs where accurate automated segmentation has not yet been described.

Methods
Two novel deep learning models (Detectron2 and YoloV8) were developed using transfer learning and compared against existing tools for background removal (macBGRemoval, remBGisnet, remBGu2net). Anonymised photograph datasets comprised training/internal validation sets (821 kidney and 400 liver images) and external validation sets (203 kidney and 208 liver images). Each image had two segmentation labels: whole organ and clear view (parenchyma only). Intersection over Union (IoU) was the primary outcome, as the recommended metric for assessing segmentation performance.

Results
In whole kidney segmentation, Detectron2 and YoloV8 outperformed other models with internal validation IoU of 0.93 and 0.94, and external validation IoU of 0.92 and 0.94, respectively. Other methods – macBGRemoval, remBGisnet and remBGu2net – scored lower, with highest internal validation IoU at 0.54 and external validation at 0.59. Similar results were observed in liver segmentation, where Detectron2 and YoloV8 both showed internal validation IoU of 0.97 and external validation of 0.92 and 0.91, respectively. The other models showed a maximum internal validation and external validation IoU of 0.89 and 0.59 respectively. All image segmentation tasks with Detectron2 and YoloV8 completed within 0.13–1.5 s per image.

Conclusions
Accurate, rapid and automated image segmentation in the context of surgical photography is possible with open-source deep-learning software. These outperform existing methods and could impact the field of surgery, enabling similar advancements seen in other areas of medical computer vision.
Splice loss in dual mode triangular index fibers: an analytic approach in the presence of nonlinearity for various V numbers
Authors: Biswas Bappa Ditya , Majumdar Angshuman , Dhar Adriza , Rakshit Ramkrishna 
Published: August 2024

Abstract
We report mathematical techniques for determining the coefficient of transmission at the splice, where anomalies like transverse and angular are present. The investigation involves the first mode of higher order (LP11) in Kerr pattern nonlinear fiber. In this case, the LP11 mode for the triangular index (TI) profile is calculated using a standard power series. Chebyshev formalism is the source of the aforementioned term. When there is third-order nonlinearity (TON), the iteration approach is utilized on the analytical mathematical terms to obtain the characteristics listed above. It has been demonstrated that our findings closely match the simulated exact outcomes obtained with the complex finite element method (FEM). Consequently, the suggested straightforward and precise technique offers enormous promise for investigating alternative propagation characteristics in dual-mode fibers.
Syntactic pausing? Re-examining the associations
Authors: Peck Naomi , Becker Laura 
Published: August 2024

Abstract
In this study, we look at the distribution of silent pauses within existing multi-language corpora to see whether their location and duration correlate with clause boundaries. Our study is based on data of seven languages from Multi-CAST. We supplemented the original clause boundary annotations with information about silent pauses in order to investigate the alignment of clause boundaries and pausing. We find a gradient association between clause boundary strength and the probability of a pause and a two-way distinction for pause duration within clauses and at clause boundaries.