bluuebunny/crossref_metadata_2025_split huggingface dataset:
An incidental prostatic leiomyoma in a dog
Authors: Holdsworth Andrew , Bléhaut Tanguy , Reeve Lizzie , Day Michael J , Warren‐Smith Chris 
Published: June 2015

A 12‐year‐old entire male cocker spaniel presented for re‐evaluation of mitral valve disease. Abdominal palpation revealed a large mass caudally. Abdominal ultrasonography identified a large, heterogeneous, mixed echogenicity mass adjacent to the bladder and prostate. A CT scan of the abdomen confirmed that the mass originated from the cranial aspect of the right prostatic lobe. The mass was of soft tissue attenuation, homogeneous, well circumscribed and displayed mild homogeneous contrast enhancement. There was overlap between the radiologic appearances of prostatic leiomyoma and prostatic carcinoma. Histopathological examination confirmed a prostatic leiomyoma. The patient did not display any clinical signs associated with this tumour and was still alive and asymptomatic three months after diagnosis. Prostatic leiomyomas are very rare in dogs, with only four cases identified within the literature over the previous 40 years; leiomyoma should be included in the differential diagnoses for an atypical prostatic mass in dogs.
Effect of Sr2TiMnO6 fillers on mechanical, dielectric and thermal behaviour of PMMA polymer
Authors: Thomas P. , Dakshayini B. S. , Kushwaha H. S. , Vaish Rahul 
Published: June 2015

Composites of poly(methyl methacrylate) (PMMA) and [Formula: see text] (STMO) were fabricated via melt mixing followed by hot pressing technique. These were characterized using X-ray diffraction (XRD), thermo gravimetric analysis (TGA), differential scanning calorimetry (DSC), thermo mechanical analysis (TMA) and impedance analyser for their structural, thermal and dielectric properties. The coefficient of thermal expansion (CTE) was measured between 40°C and 100°C for pure PMMA is 115.2 ppm/°C, which was decreased to 78.58 ppm/°C when the STMO content was increased to 50 wt.% in PMMA. There was no difference in the glass transition ([Formula: see text]) temperature of the PMMA polymer and their composites. However, the FTIR analysis indicated possible interaction between the PMMA and STMO. The density and the hardness were increased as the STMO content increased in the PMMA matrix. Permittivity was found to be as high as 30.9 at 100 Hz for the PMMA+STMO-50 wt.% composites, indicating the possibility of using these materials for capacitor applications. The thermal stability of polymer was enhanced by incorporation of STMO fillers.
Late Quaternary beach deposits and archaeological relicts on the coasts of Cyprus, and the possible implications of sea-level changes and tectonics on the early populations
Authors: Galili E. , Şevketoğlu M. , Salamon A. , Zviely D. , Mienis H. K. , Rosen B. , Moshkovitz S. 
Published: June 2015

Abstract

Late Pleistocene beach deposits in 22 selected sites around Cyprus demonstrate the vertical changes in the Earth's crust in that island over the last 125 ka. The beach/shallow-marine deposits were observed on the abraded coastal cliffs at 3–22 m above the present sea-level. They overlie Pliocene marls, and some of them contain the Senegalese marine gastropods
Persististrombus latus
,
Bursa granularis
and
Conus ermineus
that no longer live in the Mediterranean. These are index fossils for the Marine Isotope Stage (MIS) 5e in the Mediterranean and, as such, suggest an uplift of up to 15.5 m over about the last 125 ka: that is a maximal rate of 0.12 mm a
−1
. These findings are in accordance with Holocene beachrocks, abrasion platforms, wave notches and Roman/Byzantine fish tanks that retained their elevations, and thus enable the reconstruction of the coast encountered by the early colonizers. While the maximal uplift since the early Holocene has been minor and did not exceed 1.2–1.5 m, the sea-level changes have reached 40–50 m. The transition between the impermeable Pliocene marls and the porous Late Pleistocene deposits above them is the origin of freshwater springs and associated vegetation. The early colonizers seemed to recognize the potential of that essential permanent source of water and excavated wells, the earliest wells known so far. The locations of the Early Neolithic settlements (Mylouthkia and Akanthou) adjacent to visible water springs along the coastal cliffs may not be incidental. Not surprisingly, recent wells dug in the coastal Pleistocene deposits rely on the very same hydrological setting.

Supplementary material:

Appendices 1–4, which include tables and diagrams showing the vertical changes (m) and rates of vertical changes (mm ka
−1
), assuming that MIS5e isotope stage deposits are 122 ka old and are at elevation of 7.2 m asl, or 116 ka at 6.5 m, are available at
http://www.geolsoc.org.uk/SUP18830
.
New constraints on the timing of partial melting and deformation along the Nyalam section (central Himalaya): implications for extrusion models
Authors: Leloup Philippe Hervé , Liu Xiaobing , Mahéo Gweltaz , Paquette Jean-Louis , Arnaud Nicolas , Aubray Alexandre , Liu Xiaohan 
Published: June 2015

Abstract

New structural, U–Th/Pb and Ar/Ar data along the Nyalam section constrain the timing of partial melting, crystallization and deformation in the Greater Himalayan Sequence. Prograde metamorphism was followed by the onset of partial melting at
c.
30 Ma. In the central Greater Himalayan Sequence,
in situ
melts crystallized between 24 and 18 Ma. Subsequent cooling was very fast (
c.
200 °C Ma
−1
) and coeval with the emplacement of undeformed dykes that lasted until
c.
15 Ma. In the upper Greater Himalayan Sequence, fast cooling continued until
c.
13 Ma. Combined with published
P
–
T
and thermochronological data from the Langtang and Dudh Kosi valleys, these data imply that: (a) the partial melt zone thinned over time; (b) the end of melting preceded the end of motion on the Main Central Thrust and the South Tibetan Detachment by 6 and 2 Ma, respectively; (c) the South Tibetan Detachment possibly initiated at
c.
25 Ma, probably reactivating a pre-existing thrust; and (d) the present-day topography has been established for <6 Ma and focused erosion on the present-day southern slopes of the Himalaya was not active at the time of the exhumation of the Greater Himalayan Sequence. These observations suggest that the Main Central Thrust/South Tibetan Detachment systems are not passive structures induced by focused erosion, as has been suggested previously by some lower crustal channel flow models.

Supplementary material:

U/Pb, geochemistry and Ar/Ar data, the Ar/Ar analytical procedure, field pictures, T11N26, T11N27, T11N31, T11N53A and T11N40 quartz 〈C〉 axis CPOs are available at
http://www.geolsoc.org.uk/SUP18835
ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway
Authors: Li Xiao-Qing , Du Xin , Li Dong-Mei , Kong Peng-Zhou , Sun Yan , Liu Pei-Fang , Wang Qing-Shan , Feng Yu-Mei 
Published: June 2015

Abstract
Bone metastasis affects more than 70% of advanced breast cancer patients, but the molecular mechanisms of this process remain unclear. Here, we present clinical and experimental evidence to clarify the role of the integrin β-like 1 (ITGBL1) as a key contributor to bone metastasis of breast cancer. In an in vivo model system and in vitro experiments, ITGBL1 expression promoted formation of osteomimetic breast cancers, facilitating recruitment, residence, and growth of cancer cells in bone microenvironment along with osteoclast maturation there to form osteolytic lesions. Mechanistic investigations identified the TGFβ signaling pathway as a downstream effector of ITGBL1 and the transcription factor Runx2 as an upstream activator of ITGBL1 expression. In support of these findings, we also found that ITGBL1 was an essential mediator of Runx2-induced bone metastasis of breast cancer. Overall, our results illuminate how bone metastasis occurs in breast cancer, and they provide functional evidence for new candidate biomarkers and therapeutic targets to identify risk, to prevent, and to treat this dismal feature of advanced breast cancer. Cancer Res; 75(16); 3302–13. ©2015 AACR.
ДИСЦИПЛІНАРНА ДІЛОВА ГРА У ВИВЧЕННІ ПРОБЛЕМ ВЧЕННЯ ПРО КРОВ
Authors: Кушнір Р. Я. 
Published: June 2015

<p>Ділова гра містить у собі унікальні можливості для вирішення стратегії і тактики. На основі аналізу літературних джерел та досвіду автора висвітлено місце дисциплінарної ділової гри (зокрема, при вивченні проблем вчення про кров) в системі сучасної вищої медичної освіти. Розкрито підходи її застосування в навчальному процесі щодо формування та розвитку знань.</p>
ОСОБЛИВОСТІ ПРОВЕДЕННЯ ЛЕКЦІЙНИХ ЗАНЯТЬ З ДИСЦИПЛІНИ “МЕДИЧНА БІОЛОГІЯ” У СТУДЕНТІВ, ЩО НАВЧАЮТЬСЯ АНГЛІЙСЬКОЮ МОВОЮ
Authors: Фрич Н. І. 
Published: June 2015

<p>У статті розглянуто актуальні проблеми, що виникають при підготовці та проведенні лекцій з дисципліни “Медична біологія” для студентів, що навчаються англійською мовою. Запропоновано шляхи та методи удосконалення подання лекційного матеріалу для покращення розуміння термінів та понять і успішного засвоєння дисципліни. Обґрунтовано доцільність використання мультимедійних технологій для проведення лекцій. </p>
ОСОБЛИВІСТЬ ВИКЛАДАННЯ РОЗДІЛУ “ЗАХВОРЮВАННЯ СЛИЗОВОЇ ОБОЛОНКИ ПОРОЖНИНИ РОТА ПРИ ГАСТРОЕНТЕРОЛОГІЧНИХ ТА ЕНДОКРИННИХ ПАТОЛОГІЯХ У ДІТЕЙ”
Authors: Якимець М. М. 
Published: June 2015

<p><strong> </strong>У статті розглянуто пошук нових та удоскона­лення традиційних методик викладання на кафедрі дитячої стоматології.</p>
РЕЦЕНЗІЯ
Authors: Чорноус Є. С. 
Published: June 2015

Рецензія на підручник М. А. Андрейчина, О. Л. Івахова “Медсестринство при інфекційних хворобах” (видання<br />друге, доповнене і виправлене) для студентів вищих медичних навчальних закладів І–ІІІ рівнів акредитації
Проблема розвитку критичного мислення у студентів-медиків.
Authors: Корда І. В. , Геряк С. М. , Петренко Н. В. , Кузів І. Я. 
Published: June 2015

<p>У статті розглядаються питання розвитку критичного мислення в процесі організації навчального процесу студентів-медиків.</p>
ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ПІСЛЯДИПЛОМНОГО ЕТАПУ ПРАКТИЧНОЇ ПІДГОТОВКИ ЛІКАРІВ - ІНТЕРНІВ
Authors: Кулаєць В. М. 
Published: June 2015

<p>У статті представлено досвід впровадження новітніх методик навчання на кафедрі терапії і сімейної медицини Навчально-наукового інституту післядипломної освіти ДВНЗ “Івано-Франківський національний медичний університет”. Висвітлено методи навчання як спосіб впорядкованої взаємозв’язаної діяльності викладачів і лікарів-інтернів, спрямовані на вирішення завдань освіти, виховання та індивідуального розвитку в процесі навчання. Представлено засоби ефективної реалізації завдань, які відповідають сучасним вимогам для підготовки лікарів-інтернів першого та другого років навчання під час навчального процесу. У статті висвітлено перспективи використання інноваційних технологій у новій освітній моделі та власний досвід організації викладання внутрішньої медицини лікарям-інтернам на етапі післядипломного навчання. Відзначено, що новітні методи навчання сприятимуть безперервному професійному росту лікарів-інтернів та підготовці висококваліфікованих фахівців.</p>
СУЧАСНІ МЕТОДИ НАВЧАННЯ ПРИ ВИКЛАДАННІ ТЕХНОЛОГІЇ ЛІКІВ НА СУЧАСНОМУ ЕТАПІ РОЗВИТКУ ВИЩОЇ МЕДИЧНОЇ ШКОЛИ
Authors: Донченко Н. В. 
Published: June 2015

<p class="MsoNormal" style="text-align: justify; line-height: normal;"><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ansi-language: UK;" lang="UK">Серед дисциплін, які формують провізора як фахівця у певній галузі, значне місце займає технологія ліків. У формуванні майбутнього провізора-спеціаліста<span style="mso-spacerun: yes;"> </span>важливе місце мають теоретична підготовка та практична спрямованість.Використання сучасних методів навчання сприяє кращому засвоєнню матеріалу та має практичну значимість. Персональний комп’ютер, що активно задіяний у навчальному процесі,<span style="mso-spacerun: yes;"> </span>з комплексом програмного забезпечення та електронними</span></strong><strong style="mso-bidi-font-weight: normal;"></strong><strong style="mso-bidi-font-weight: normal;"><span style="font-size: 12.0pt; font-family: 'Times New Roman','serif'; mso-ansi-language: UK;" lang="UK">посібниками, мультимедійними презентаціями та базою тестових завдань дозволяє оптимізувати процес навчання та здійснювати індивідуальний<span style="mso-spacerun: yes;"> </span>підхід до отримання знань<span style="mso-spacerun: yes;"> </span>студентами.<span style="mso-spacerun: yes;"> </span>Навчальні посібники, розроблені кафедрою, сприяють професійній підготовці студентів завдяки<span style="mso-spacerun: yes;"> </span>спеціальному компонуванню матеріалу, зокрема нормативних документів.</span></strong></p>
Selective Vulnerability of Cortical Border Zone to Microembolic Infarct
Authors: Bergui Mauro , Castagno Davide , D’Agata Federico , Cicerale Alessandro , Anselmino Matteo , Maria Ferrio Federica , Giustetto Carla , Halimi Franck , Scaglione Marco , Gaita Fiorenzo 
Published: June 2015

Background and Purpose—
Endovascular procedures, including atrial fibrillation transcatheter ablation, may cause microembolization of brain arteries. Microemboli often cause small sized and clinically silent cerebral ischemias (SCI). These lesions are clearly visible on early postoperative magnetic resonance diffusion-weighted images. We analyzed SCI distribution in a population of patients submitted to atrial fibrillation transcatheter ablation.

Methods—
Seventy-eight of 927 consecutive patients submitted to atrial fibrillation transcatheter ablation were found positive for acute SCI on a postoperative magnetic resonance. SCI were identified and marked, and their coordinates were transformed from native space into the International Consortium for Brain Mapping/Montreal Neurological Institute space. We then computed the voxel-wise probability distribution map of the SCI using the activation likelihood estimation approach.

Results—
SCI were more commonly found in the cortex. In supratentorial regions, SCI selectively involved cortical border zone between anterior, middle, and posterior cerebral arteries; in infratentorial regions, distal territory of posteroinferior cerebellar artery. Possible explanations include selective embolization, linked to the vascular anatomy of pial arteries supplying those territories, reduced clearance of emboli in a relatively hypoperfused zone, or a combination of both. This particular distribution of lesions has been reported in both animal models and in patients with microemboli of different sources.

Conclusions—
A selective vulnerability of cortical border zone to microemboli occurring during atrial fibrillation transcatheter ablation was observed. We hypothesize that such selectivity may apply to microemboli of different sources.
A TAXONOMIC REVIEW AND A NEW SPECIES OF THE SOUTH AMERICAN WOODY GENUS AMBURANA (LEGUMINOSAE, PAPILIONOIDEAE)<br />
Authors: Seleme Elidiene P. , LEWIS GWILYM P. , STIRTON CHARLES H. , Sartori Ângela L.b. , Mansano Vidal F. 
Published: June 2015

A taxonomic revision of the South American genus Amburana comprised of three species is presented, including the new species A. erythrosperma which is described and illustrated. Amburana cearensis occurs widely in Argentina, Bolivia, Brazil and Paraguay. Amburana acreana occurs in the Bolivian, Brazilian and Peruvian Amazon. Amburana erythrosperma is endemic to the southern Chapada Diamantina, Bahia, Brazil. The species are distinguished by the color of the stem, the number per leaf and shape of leaflets, the size of inflorescence, color and size of the standard petal, fruit with endocarp developed to form a papery wing surrounding the seed or this lacking, and color of seed. A key to the species is provided together with descriptions, taxonomic comments, geographical distribution maps and illustrations for each. Lectotypes for A. acreana and A. cearensis are designated.
The Ankle-Brachial Index is Associated With Cardiovascular Complications After Noncardiac Surgery
Authors: Carmo G. A. , Calderaro D. , Gualandro D. M. , Pastana A. F. , Yu P. C. , Marques A. C. , Caramelli B. 
Published: June 2015

Background: This study evaluated the association of the ankle-brachial index (ABI) and cardiovascular complications after noncardiac surgery. Methods: We prospectively evaluated patients referred for noncardiac surgery. The ABI was performed before surgery. Patients with abnormal ABI (≤0.9) were included in the peripheral artery disease (PAD) group and the remaining constituted the control group. Cardiac troponin and electrocardiogram were obtained 72 hours after surgery. Patients were followed up to 30 days, and primary end point was the occurrence of any cardiovascular event: cardiovascular death, acute coronary syndrome, isolated troponin elevation (ITE), decompensated heart failure, cardiogenic shock, unstable arrhythmias, nonfatal cardiac arrest, pulmonary edema, stroke, or PAD symptoms increase. Results: We evaluated 124 patients (61.3% male; mean age 65.4 years). During the study, 57.9% of patients in the PAD group had an event versus 25.7% in the control group ( P = .011). The ITE was the most observed event (24.2%). After logistic regression, the odds ratio for ITE was 7.4 (95% confidence interval 2.2-25.0, P = .001). Conclusions: In patients submitted to noncardiac surgery, abnormal ABI is associated with a higher occurrence of a cardiovascular event.
Influencing Trust for Human–Automation Collaborative Scheduling of Multiple Unmanned Vehicles
Authors: Clare Andrew S. , Cummings Mary L. , Repenning Nelson P. 
Published: June 2015

Objective: We examined the impact of priming on operator trust and system performance when supervising a decentralized network of heterogeneous unmanned vehicles (UVs). Background: Advances in autonomy have enabled a future vision of single-operator control of multiple heterogeneous UVs. Real-time scheduling for multiple UVs in uncertain environments requires the computational ability of optimization algorithms combined with the judgment and adaptability of human supervisors. Because of system and environmental uncertainty, appropriate operator trust will be instrumental to maintain high system performance and prevent cognitive overload. Method: Three groups of operators experienced different levels of trust priming prior to conducting simulated missions in an existing, multiple-UV simulation environment. Results: Participants who play computer and video games frequently were found to have a higher propensity to overtrust automation. By priming gamers to lower their initial trust to a more appropriate level, system performance was improved by 10% as compared to gamers who were primed to have higher trust in the automation. Conclusion: Priming was successful at adjusting the operator’s initial and dynamic trust in the automated scheduling algorithm, which had a substantial impact on system performance. Application: These results have important implications for personnel selection and training for futuristic multi-UV systems under human supervision. Although gamers may bring valuable skills, they may also be potentially prone to automation bias. Priming during training and regular priming throughout missions may be one potential method for overcoming this propensity to overtrust automation.
A consensus definition of occupation-based intervention from a Malaysian perspective: A Delphi study
Authors: Che Daud Ahmad Zamir , Yau Matthew K , Barnett Fiona 
Published: June 2015

Introduction Descriptions and definitions for occupation-based intervention vary in the literature. Occupation-based intervention is assumed to be based on occupation and is seen as both a means and an end. Occupation-based intervention also includes all levels of interventions in occupational therapy as long as the goal is occupational performance. Occupation-based intervention can also be described as a therapeutic process that emerges during the therapy session. The purpose of this study was to achieve a consensus definition of occupation-based intervention among Malaysian occupational therapists. Method A three-round Delphi technique using a sequential questionnaire was conducted. Fifteen occupational therapists and occupational therapy educators completed all rounds. The Delphi process began with open-ended questions, asking the participants some questions about occupation-based intervention. The second and third rounds asked participants to rank their agreement with statements about occupation-based intervention. Results Occupation-based intervention is seen by therapists to be both a means and an end, with occupational performance as the main outcome. It is believed that using occupation alone is not enough; preparatory and purposeful methods may have to be incorporated to achieve the outcomes. Conclusion It is important to adopt a common definition of occupation-based intervention in practice and education to signify occupation at the centre of occupational therapy.
Rates and Predictors of Invalid Baseline Test Performance in High School and Collegiate Athletes for 3 Computerized Neurocognitive Tests
Authors: Nelson Lindsay D. , Pfaller Adam Y. , Rein Lisa E. , McCrea Michael A. 
Published: June 2015

Background: Preseason baseline testing using computerized neurocognitive tests (CNTs) is increasingly performed on athletes. Adequate effort is critical to establish valid estimates of ability, but many users do not evaluate performance validity, and the conditions that affect validity are not well understood across the available CNTs. Purpose: To examine the rates and predictors of invalid baseline performance for 3 popular CNTs: Automated Neuropsychological Assessment Metrics (ANAM), Axon Sports, and Immediate Post-Concussion and Cognitive Testing (ImPACT). Study Design: Controlled laboratory study. Methods: High school and collegiate athletes (N = 2063) completed 2 of 3 CNTs each during preseason evaluations. All possible pairings were present across the sample, and the order of administration was randomized. Examiners provided 1-on-1, scripted pretest instructions, emphasizing the importance of good effort. Profile validity was determined by the manufacturers’ standard criteria. Results: The overall percentage of tests flagged as of questionable validity was lowest for ImPACT (2.7%) and higher for ANAM and Axon (10.7% and 11.3%, respectively). The majority of invalid baseline profiles were flagged as such because of failure on only 1 validity criterion. Several athlete and testing factors (eg, attention deficit hyperactivity disorder [ADHD], estimated general intellectual ability, administration order) predicted validity status for 1 or more CNTs. Considering only first CNT administrations and participants without ADHD and/or a learning disability (n = 1835) brought the rates of invalid baseline performances to 2.1%, 8.8%, and 7.0% for ImPACT, ANAM, and Axon, respectively. Invalid profiles on the Medical Symptom Validity Test (MSVT) were rare (1.8% of participants) and demonstrated poor correspondence to CNT validity outcomes. Conclusion: The validity criteria for these CNTs may not identify the same causes of invalidity or be equally sensitive to effort. The validity indicators may not be equally appropriate for some athletes (eg, those with neurodevelopmental disorders). Clinical Relevance: The data suggest that athletes do not put forth widespread low effort or that some validity criteria are more sensitive to invalid performance than others. It is important for examiners to be aware of the conditions that maximize the quality of baseline assessments and to understand what sources of invalid performance are captured by the validity criteria that they obtain.
One hundred years of lessons about the impact of war on mental health; two steps forward, one step back
Authors: McFarlane Alexander C 
Published: June 2015

Objective: This paper outlines the substantial stigmatization of soldiers who suffered psychiatric disorders during World War I, and how there was little acceptance of the enduring impact of prolonged combat exposure once the war ended. Conclusion: Recent decades of research highlight the delayed impact of combat exposure and its long-term neurobiological consequences.