bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimizing water relations, gas exchange parameters, biochemical attributes and yield of water-stressed maize plants through seed priming with iron oxide nanoparticles
Authors: Mazhar Muhammad Waqas , Ishtiaq Muhammad , Maqbool Mehwish , Muzammil Khursheed , Mohieldin Ali , Dawria Adam , Altijani Abdelrhman Ahmed Galaleldin , Salih Ahmed , Ali Omar Yousof M. , Elzaki Ahmed Abdelgadir Mohamed , Adam Bhgah I. Yusuf , Adam Hamza Abdullah M. 
Published: July 2024

AbstractDrought poses significant risks to maize cultivation by impairing plant growth, water uptake and yield; nano priming offers a promising avenue to mitigate these effects by enhancing plant water relations, stress tolerance and overall productivity. In the current experiment, we tested a hypothesis that seed priming with iron oxide nanoparticles (n-Fe2O3) can improve maize performance under water stress by improving its growth, water relations, yield and biochemical attributes. The experiment was conducted on a one main plot bisected into two subplots corresponding to the water and drought environments. Within each subplot, maize plants were raised from n-Fe2O3 primed seeds corresponding to 0 mg. L− 1 (as control treatment), 25, 50, 75, and 100 mg. L− 1 (as trial treatments). Seed priming with n-Fe2O3 at a concentration of 75 mg. L− 1 improved the leaf relative water content, water potential, photosynthetic water use efficiency, and leaf intrinsic water use efficiency of maize plants by 13%, 44%, 64% and 17%, respectively compared to control under drought stress. The same treatments improved plant biochemical attributes such as total chlorophyll content, total flavonoids and ascorbic acid by 37%, 22%, and 36%, respectively. Seed priming with n-Fe2O3 accelerated the functioning of antioxidant enzymes such as SOD and POD and depressed the levels of leaf malondialdehyde and hydrogen peroxide significantly. Seed priming with n-Fe2O3 at a concentration of 75 mg. L− 1 improved cob length, number of kernel rows per cob, and 100 kernel weight by 59%, 27% and 33%, respectively, under drought stress. Seed priming with n-Fe2O3 can be used to increase maize production under limited water scenarios.
Pulmonary embolism in patients with chronic coronary syndrome masquerading as acute coronary syndrome: a case report and literature review
Authors: Chen Yun-Hu , Zhu Xing-Yu , Fan Li-Hua , Xu Hong-Feng 
Published: July 2024

Abstract
Background
Pulmonary embolisms (PEs) exhibit clinical features similar to those of acute coronary syndrome (ACS), including electrocardiographic abnormalities and elevated troponin levels, which frequently lead to misdiagnoses in emergency situations.

Case presentation
Here, we report a case of PE coinciding with chronic coronary syndrome in which the patient’s condition was obscured by symptoms mimicking ACS. A 68-year-old female with syncope presented to the hospital. Upon admission, she was found to have elevated troponin levels and an electrocardiogram showing ST-segment changes across multiple leads, which initially led to a diagnosis of ACS. Emergency coronary arteriography revealed occlusion of the posterior branches of the left ventricle of the right coronary artery, but based on the complexity of the intervention, the occlusion was considered chronic rather than acute. On the 3rd day after admission, the patient experienced recurrent chest tightness and shortness of breath, which was confirmed as acute PE by emergency computed tomography pulmonary angiography. Following standardized anticoagulation treatment, the patient improved and was subsequently discharged.

Conclusions
This case report highlights the importance of recognizing the nonspecific features of PE. Clinicians should be vigilant when identifying other clinical features that are difficult to explain accompanying the expected disease, and it is necessary to carefully identify the causes to prevent missed diagnoses or misdiagnoses.
Exploring the mystical relationship between the Moon, Sun, and birth rate
Authors: Londero Ambrogio P. , Bertozzi Serena , Messina Gabriele , Xholli Anjeza , Michelerio Virginia , Mariuzzi Laura , Prefumo Federico , Cagnacci Angelo 
Published: July 2024

Abstract
Objective
The Moon has a noticeable influence on the Earth due to its gravity, the most visible manifestation of which are tides. We aimed to see if the Moon’s daily cycle, like the Sun’s, affects the prevalence and incidence of childbirth.

Methods
In this retrospective cohort study, we examined all deliveries at the Academic Hospital of Udine between 2001 and 2019. All consecutive singleton pregnancies with spontaneous labor and vaginal delivery were included.

Results
During the period, 13,349 singleton pregnancies with spontaneous labor and vaginal delivery were delivered in 6939 days. A significantly higher prevalence of deliveries was found with the Moon above the horizon (50.63% vs. 49.37%, p < 0.05). Moreover, during the day, there was a significantly higher prevalence of deliveries than during nighttime (53.74% vs. 45.79%, p < 0.05). Combining the Moon and Sun altitude, the majority of deliveries were registered when both were above the horizon (27.39% vs. 26.13%, 23.25%, or 23.24%, p < 0.05). These findings were confirmed in multivariate analysis after adjusting for parity, gestational age, or season. We found no correlation between birth and the Moon phase.

Conclusions
Our data support the interaction of the Moon and the Sun in determining the time of birth. More research is needed to understand these phenomena and improve our understanding of labor initiation mechanisms.
Clinical effect of modified anterolateral acromioarthroplasty during arthroscopic rotator cuff repair
Authors: Zhou Yongwei , Kang Jiayu , Yang Qining 
Published: July 2024

Abstract
Background
This study aimed to compare the clinical effect of modified anterolateral and traditional acromioplasty in arthroscopic rotator cuff repair.

Methods
The clinical data of 92 patients with total rotator cuff tears admitted to the Department of Joint Surgery of Jinhua Central Hospital from January 2016 to December 2019 were retrospectively analyzed. Among them, 42 patients underwent traditional acromioplasty during arthroscopic rotator cuff repair, and 50 underwent modified anterolateral acromioplasty. Patients were evaluated for preoperative and postoperative shoulder function, pain and critical shoulder angle, and incidence of rotator cuff re-tear at 12 months postoperatively.

Results
The preoperative general data of patients in the classic and modified anterolateral acromioplasty groups did not differ significantly (P > 0.05) and were comparable. The UCLA, ASES, and Constant shoulder joint scores were significantly improved in both groups. The VAS score was significantly decreased at 12 months postoperative than preoperative, with a statistically significant difference (P ≤ 0.05). Shoulder function and pain scores did not differ significantly between the two groups at 12 months postoperatively (P > 0.05). The CSA did not differ significantly between preoperative and postoperative 12 months in the traditional acromioplasty group (P > 0.05). However, 12 months postoperative CSA in the modified anterolateral acromioplasty group was significantly smaller than the preoperative CSA, with a statistically significant difference (P ≤ 0.05). The rates of rotator cuff re-tears were 16.67% (7/42) and 4% (2/50) in the two groups at 12 months postoperatively, respectively, with statistically significant differences (P ≤ 0.05).

Conclusions
Traditional and modified anterolateral acromioplasty while treating total rotator cuff tears using arthroscopic rotator cuff repair significantly improves shoulder joint function. However, modified anterolateral acromioplasty significantly reduced the CSA value and decreased the incidence of rotator cuff re-tears.
A critical influence of HIF-1 on MMP-9 and Galectin-3 in oral lichen planus
Authors: Hazzaa Hala H. , El Shiekh Marwa A. M. , Elkashty Osama , Magdy Eman , Riad Dalia , khalifa Eman , Elewa Gasser M. , Kamal Naglaa M. 
Published: July 2024

Abstract
Objective
Oral lichen planus carries a risk for malignancy. The pathogenesis of the disease is mediated by various inflammatory mediators. Several mediators could be responsible for the oncogenic behavior in certain cases. Hypoxia-inducible factor-1a (HIF-1), and its possible correlation to Galactin-3 (Gal-3) and matrix metalloproteinase-9 (MMP-9) over expression represents an important indicator for malignant transformation. The investigation of these factors may present evidence-based information on malignant transformation of the disease.

Subjects and methods
The study investigated the expression of HIF-1, Gla-3 and MMP-9 in tissue samples of OLP compared to control subjects of un-inflamed gingival overgrowth. 20 biospecimen were allocated in each group.

Results
Immunohistochemical findings of OLP showed immunoreactivity for Galectin 3, HIF1a and MMP-9 by most of the epithelial cells. There was a positive correlation between HIF1α and MMP-9, r = 0.9301 (P-value < 0.00001). A positive correlation was detected between Galectin 3 and MMP-9, r = 0.7292 (P-value = 0.000264) between Galectin 3 and HIF1α, r = 0.5893 (P-value = 0.006252).

Conclusion
These findings confirm the hypothesis that the adaptive pathways to hypoxia as Gal 3 and MMP-9 expressions and their HIF-1 may play a crucial role in carcinogenesis of OLP.
Using community-based participatory research methods to build the foundation for an equitable integrated health data system within a Canadian urban context
Authors: Fierheller Dianne , Chu Casey , D’Silva Chelsea , Krishendeholl Arvind , Arham Abdul , Carter Angela , Dias Keddone , Francis Isaac , Glasgow Marcia , Malhotra Gurpreet , Zenlea Ian , Rosella Laura C. 
Published: July 2024

AbstractHealth inequalities amplified by the COVID-19 pandemic have disproportionately affected racialized and equity-deserving communities across Canada. In the Municipality of Peel, existing data, while limited, illustrates that individuals from racialized and equity-deserving communities continue to suffer, receive delayed care, and die prematurely. In response to these troubling statistics, grassroots community advocacy has called on health systems leaders in Peel to work with community and non-profit organizations to address the critical data and infrastructure gaps that hinder addressing the social determinants of health in the region. To support these advocacy efforts, we used a community-based participatory research approach to understand how we might build a data collection ecosystem across sectors, alongside community residents and service providers, to accurately capture the data about the social determinants of health. This approach involved developing a community engagement council, defining the problem with the community, mapping what data is actively collected and what is excluded, and understanding experiences of sociodemographic data collection from community members and service providers. Guided by community voices, our study focused on sociodemographic data collection in the primary care context and identified which service providers use and collect these data, how data are used in their work, the facilitators and barriers to data use and collection. Additionally, we gained insight into how sociodemographic data collection could be respectful, safe, and properly governed from the perspectives of community members. From this study, we identify a set of eight recommendations for sociodemographic data collection and highlight limitations. This foundational community-based work will inform future research in establishing data governance in partnership with diverse and equity-deserving communities.
Integrated domestic violence and reproductive health interventions in India: a systematic review
Authors: Sabri Bushra , Mani Serena Sloka , Kaduluri Venkata Preetam Sandeep 
Published: July 2024

Abstract
Background
Domestic violence is a leading cause of poor health outcomes during pregnancy and the postpartum period. Therefore, there is a need for integrated domestic violence interventions in reproductive health care settings. India has one of the highest maternal and child mortality rates. This review aimed to identify characteristics of existing evidence-based integrated domestic violence and reproductive healthcare interventions in India to identify gaps and components of interventions that demonstrate effectiveness for addressing domestic violence.

Methods
A systematic review of intervention studies was conducted using Preferred Reporting Items for Systematic Reviews and Meta-Analyses. Three research team members performed independent screening of title, abstracts and full-texts.

Results
The search resulted in 633 articles, of which 13 articles met inclusion criteria for full text screening and analysis. Common components of integrated violence and reproductive health interventions that were effective in addressing domestic violence included: psychoeducation/education (n = 5), skill building (n = 5), counseling (n = 5), engaging stakeholders with use of trained lay peer facilitators (n = 3), and engaging male spouses (n = 3).

Conclusions
Interventions in India for domestic violence that are integrated with reproductive health care remain few, and there are fewer with effective outcomes for domestic violence. Of those with effective outcomes, all of the interventions utilized psychoeducation/education, skill building, and counseling as part of the intervention.
An improved bacterial mRNA enrichment strategy in dual RNA sequencing to unveil the dynamics of plant-bacterial interactions
Authors: Shilpha Jayabalan , Lee Junesung , Kwon Ji-Su , Lee Hyun-Ah , Nam Jae-Young , Jang Hakgi , Kang Won-Hee 
Published: July 2024

Abstract
Background
Dual RNA sequencing is a powerful tool that enables a comprehensive understanding of the molecular dynamics underlying plant-microbe interactions. RNA sequencing (RNA-seq) poses technical hurdles in the transcriptional analysis of plant-bacterial interactions, especially in bacterial transcriptomics, owing to the presence of abundant ribosomal RNA (rRNA), which potentially limits the coverage of essential transcripts. Therefore, to achieve cost-effective and comprehensive sequencing of the bacterial transcriptome, it is imperative to devise efficient methods for eliminating rRNA and enhancing the proportion of bacterial mRNA. In this study, we modified a strand-specific dual RNA-seq method with the goal of enriching the proportion of bacterial mRNA in the bacteria-infected plant samples. The enriched method involved the sequential separation of plant mRNA by poly A selection and rRNA removal for bacterial mRNA enrichment followed by strand specific RNA-seq library preparation steps. We assessed the efficiency of the enriched method in comparison to the conventional method by employing various plant-bacterial interactions, including both host and non-host resistance interactions with pathogenic bacteria, as well as an interaction with a beneficial rhizosphere associated bacteria using pepper and tomato plants respectively.

Results
In all cases of plant-bacterial interactions examined, an increase in mapping efficiency was observed with the enriched method although it produced a lower read count. Especially in the compatible interaction with Xanthmonas campestris pv. Vesicatoria race 3 (Xcv3), the enriched method enhanced the mapping ratio of Xcv3-infected pepper samples to its own genome (15.09%; 1.45-fold increase) and the CDS (8.92%; 1.49-fold increase). The enriched method consistently displayed a greater number of differentially expressed genes (DEGs) than the conventional RNA-seq method at all fold change threshold levels investigated, notably during the early stages of Xcv3 infection in peppers. The Gene Ontology (GO) enrichment analysis revealed that the DEGs were predominantly enriched in proteolysis, kinase, serine type endopeptidase and heme binding activities.

Conclusion
The enriched method demonstrated in this study will serve as a suitable alternative to the existing RNA-seq method to enrich bacterial mRNA and provide novel insights into the intricate transcriptomic alterations within the plant-bacterial interplay.
Clinical trial results in context: comparison of baseline characteristics and outcomes of 38,510 RECOVERY trial participants versus a reference population of 346,271 people hospitalised with COVID-19 in England
Authors: Pessoa-Amorim Guilherme , Goldacre Raphael , Crichton Charles , Stevens Will , Nunn Michelle , King Andy , Murray Dave , Welsh Richard , Pinches Heather , Rees Andrew , Morris Eva J. A. , Landray Martin J. , Haynes Richard , Horby Peter , Wallendszus Karl , Peto Leon , Campbell Mark , Harper Charlie , Mafham Marion 
Published: July 2024

Abstract
Background
Randomised trials are essential to reliably assess medical interventions. Nevertheless, interpretation of such studies, particularly when considering absolute effects, is enhanced by understanding how the trial population may differ from the populations it aims to represent.

Methods
We compared baseline characteristics and mortality of RECOVERY participants recruited in England (n = 38,510) with a reference population hospitalised with COVID-19 in England (n = 346,271) from March 2020 to November 2021. We used linked hospitalisation and mortality data for both cohorts to extract demographics, comorbidity/frailty scores, and crude and age- and sex-adjusted 28-day all-cause mortality.

Results
Demographics of RECOVERY participants were broadly similar to the reference population, but RECOVERY participants were younger (mean age [standard deviation]: RECOVERY 62.6 [15.3] vs reference 65.7 [18.5] years) and less frequently female (37% vs 45%). Comorbidity and frailty scores were lower in RECOVERY, but differences were attenuated after age stratification. Age- and sex-adjusted 28-day mortality declined over time but was similar between cohorts across the study period (RECOVERY 23.7% [95% confidence interval: 23.3–24.1%]; vs reference 24.8% [24.6–25.0%]), except during the first pandemic wave in the UK (March–May 2020) when adjusted mortality was lower in RECOVERY.

Conclusions
Adjusted 28-day mortality in RECOVERY was similar to a nationwide reference population of patients admitted with COVID-19 in England during the same period but varied substantially over time in both cohorts. Therefore, the absolute effect estimates from RECOVERY were broadly applicable to the target population at the time but should be interpreted in the light of current mortality estimates.

Trial registration
ISRCTN50189673- Feb. 04, 2020, NCT04381936- May 11, 2020.
Random forest and spatial cross-validation performance in predicting species abundance distributions
Authors: Mushagalusa Ciza Arsène , Fandohan Adandé Belarmain , Glèlè Kakaï Romain 
Published: July 2024

AbstractRandom forests (RF) have been widely used to predict spatial variables. Several studies have shown that spatial cross-validation (CV) methods consistently cause RF to yield larger prediction errors compared to standard CV methods. This study examined the impact of species characteristics and data features on the performance of the standard RF and spatial CV approaches for predicting species abundance distribution. It compared the standard 5-fold CV, design-based validation, and three different spatial CV methods, such as spatial buffering, environmental blocking, and spatial blocking. Validation samples were randomly selected for design-based validation without replacement. We evaluated their predictive performance (accuracy and discrimination metrics) using artificial species abundance data generated by a linear function of a constant term ($$\beta _0$$

β
0

) and a random error term following a zero-mean Gaussian process with a covariance matrix determined by an exponential correlation function. The model was tuned over multiple simulations to consider different mean levels of species abundance, spatial autocorrelation variation, and species detection probability. Here we found that the standard RF had poor predictive performance when spatial autocorrelation was high and the species probability of detection was low. Design-based validation and standard K-fold CV were found to be the most effective strategies for evaluating RF performance compared to spatial CV methods, even in the presence of high spatial autocorrelation and imperfect detection for random samples. For weakly or moderately clustered samples, they yielded good modelling efficiency but overestimated RF’s predictive power, while they overestimated modelling efficiency, predictive power, and accuracy for strongly clustered samples with high spatial autocorrelation. Globally, the checkerboard pattern in the allocation of blocks to folds in blocked spatial CV was found to be the most effective CV approach for clustered samples, whatever the degree of clustering, spatial autocorrelation, or species abundance class. The checkerboard pattern in spatial CV was found to be the best method for random or systematic samples with spatial autocorrelation, but less effective than non-spatial CV approaches. Failing to take data features into account when validating models can lead to unrealistic predictions of species abundance and related parameters and, therefore, incorrect interpretations of patterns and conclusions. Further research should explore the benefits of using blocked spatial K-fold CV with checkerboard assignment of blocks to folds for clustered samples with high spatial autocorrelation.
Age- and gender-specific acute poisoning with drugs and medications affecting nervous system
Authors: Mesgarpour Bita , Faridfar Shabnam , Rezaei Mahya , Abdollahiasl Akbar , Shadnia Shahin , Mahdavinejad Arezou , Abdollahi Mohammad 
Published: July 2024

Abstract
Background
We investigated acute poisonings resulting from medications affecting the nervous system and illicit substances at Loghman Hakim Hospital in Tehran.

Methods
We retrospectively reviewed patient records at Iran’s largest tertiary toxicology referral center between January 2010 and December 2015. We analyzed the prevalence, trend, age and gender distribution of acute poisoning caused by nervous system agents.

Results
The present study included 16,657 (57.27%) males and 12,426 (42.73%) females, resulting in 29,083 patients. The median age of men and women was 29 and 26 years, respectively (p < 0.0001). There were 12,071 (72.47%) men and 10,326 (83.10%) women under the age of 40 (p < 0.001). Most cases were intentional (69.38% in men and 79.00% in women, p < 0.001) and 44.10% had a history of poisoning. The proportions of men and women varied significantly between different age groups and nervous system agents. For women, the most common agent was alprazolam, whereas for men, methadone. The overall trend of acute poisoning with drug used in addictive disorders, opioids and alcohol was increasing but decreasing with benzodiazepines and antidepressants. Acute poisoning by nervous system agents led to more deaths in men (1.95% vs. 0.56%; p < 0.001).

Conclusions
Methadone intoxication was common especially among young men and most of these intoxications were intentional. Women and men aged 20–29 most frequently suffer poisoning from alprazolam and clonazepam, respectively. Women over 60 and men over 30 used opium. Illicit drugs caused more than half of the deaths, and opium dominated. This study may create awareness and develop educational and preventive gender and age-specific local programs.