bluuebunny/crossref_metadata_2025_split huggingface dataset:
Laparoscopic versus open radical hysterectomy in patients with stage IB2 and IIA2 cervical cancer
Authors: Park Jeong‐Yeol , Kim Dae‐Yeon , Kim Jong‐Hyeok , Kim Yong‐Man , Kim Young‐Tak , Nam Joo‐Hyun 
Published: June 2013

AbstractObjectivesTo compare survival and surgical outcomes of laparoscopic (LRH) and open radical hysterectomy (ORH) in patients with stage IB2 and IIA2 cervical cancer.MethodsA retrospective analysis was performed on 303 patients with stage IB2 and IIA2 cervical cancer who underwent LRH (n = 115) or ORH (n = 188).ResultsTwo patients (1.7%) in the LRH group required conversion to laparotomy. There was no difference with respect to operating time, perioperative change in hemoglobin level, and need for transfusion. However, in the LRH group, estimated blood loss (P = 0.003) was significantly lower, time to recovery of bowel movement (P < 0.001) and length of postoperative hospital stay (P < 0.001) were significantly shorter, and postoperative complications were significantly less frequent (P = 0.036). The 5‐year disease‐free survival was 78% in the LRH group and 77% in the ORH group (P = 0.718), and 5‐year overall survival was 83% in both groups (P = 0.746). There were no differences in pattern of recurrence (P = 0.225) and median time to recurrence (12 vs. 13 months; P = 0.240).ConclusionsLRH has similar therapeutic efficacy to ORH in patients with bulky early‐stage cervical cancer. However, LRH has more favorable surgical outcomes. Therefore, LRH is not only a reasonable alternative to ORH but also the preferred surgical procedure for these patients. J. Surg. Oncol. 2013 108:63–69. © 2013 Wiley Periodicals, Inc.
Iterative cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for recurrent peritoneal metastases
Authors: Chua Terence C. , Quinn Liam E. , Zhao Jing , Morris David L. 
Published: June 2013

AbstractBackgroundCytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) achieves disease control within the peritoneum but recurrences occur. This study examines the outcomes of iterative CRS (iCRS) HIPEC for treatment of recurrent peritoneal metastases.MethodsPatients who underwent iCRS in a single tertiary referral center were identified from a prospective database. Safety analysis was performed and clinicopathological variables were analyzed to assess factors predictive of major morbidity and survival.ResultsThe demographics of patients who underwent primary cytoreductive surgery (pCRS) (n = 466) and iCRS (n = 79) were balanced between groups. pCRS was shown to require more blood transfusion (P = 0.019) and albumin use (P = 0.013). The mortality and major complication rates were comparable (1.2% vs. 0%; P = 0.600, and 42% vs. 41%; P = 0.806). Residual pneumothorax occurred more frequently after pCRS (12% vs. 4%; P = 0.030). Factors associated with major complications after iCRS include use of HIPEC (P = 0.042) and length of hospital stay (P = 0.024). The overall median survival was 48 months and 5‐year survival was 34%. By cancer type, the 3‐year survival was 0%, 74%, 80%, and 72% for colorectal, appendiceal pseudomyxoma, peritoneal mesothelioma, and appendix cancer, respectively. Independent predictors of survival include age (P = 0.049), interval between pCRS and iCRS (P = 0.008), small bowel resection (P < 0.001), and use of HIPEC (P = 0.005).ConclusionIterative CRS achieved further peritoneal disease control without adverse effects on morbidity. Patients with appendiceal tumors and peritoneal mesothelioma appear to benefit most after iCRS. Intraoperative HIPEC remains important in the repetoire of managing these patients. J. Surg. Oncol. 2013; 108:81–88 © 2013 Wiley Periodicals, Inc.
Paleoproductivity during the middle Miocene carbon isotope events: A data‐model approach
Authors: Diester‐Haass Liselotte , Billups Katharina , Jacquemin Ingrid , Emeis Kay C. , Lefebvre Vincent , François Louis 
Published: June 2013

AbstractTo what extent are individual middle Miocene eccentricity‐scale benthic foraminiferal carbon isotope maxima (the so‐called CM events) related to changes in marine export productivity? Here we use benthic foraminiferal accumulation rates from three sites in the Pacific and Southern Oceans and a geochemical box model to assess relationships between benthic foraminiferal δ13C records, export productivity, and the global carbon cycle. Results from Deep Sea Drilling Project Hole 588 and Ocean Drilling Program Site 747 show a distinct productivity maximum during CM 6 at 13.8 Ma, the time of major expansion of ice on Antarctica. Productivity maxima during other CM events are only recorded at high‐latitude Site 747. A set of numerical experiments tests whether changes in foraminiferal δ13C records (CM events) and export productivity can be simulated solely by sea level fluctuations and the associated changes in global weathering‐deposition cycles, by sea level fluctuations plus global climatic cooling, and by sea level fluctuations plus invigorated ocean circulation. Consistent with data, the periodic forcing of sea level and albedo (and associated weathering cycles) produces δ13C variations of the correct temporal spacing, albeit with a reduced amplitude. A productivity response of the correct magnitude is achieved by enhancing ocean circulation during cold periods. We suggest that the pacing of middle Miocene δ13C fluctuations is associated with cyclical sea level variations. The amplitude, however, is muted perhaps due to the competing effects of a time‐lagged response to sea level lowstands but an immediate response to invigorated ocean circulation during cold phases.
Pregnancy‐associated plasma protein A levels and neonatal complications in post‐date pregnancies
Authors: Zizzo Anne R. , Kirkegaard Ida , Henriksen Tine B. , Ulbjerg Niels 
Published: June 2013

ABSTRACTObjectivesTo assess the association between serum pregnancy‐associated plasma protein A (PAPP‐A) and free β‐human chorionic gonadotropin (free β‐hCG) in the first trimester and perinatal complications in post‐date pregnancies.MethodsA total of 4948 women, who delivered after 40 gestational weeks, were included. Labour was not induced routinely until 42 weeks. Serum levels of PAPP‐A and free β‐hCG were determined at the first‐trimester screening for Down syndrome. Neonatal complications were obtained from specific registration forms filled out by senior neonatologists.ResultsIn post‐date pregnancies, PAPP‐A < 0.4 multiples of the median was associated with Apgar score of less than 7 at 5 min (ORadj 5.4, 95% CI 2.0–14.3), admission to the neonatal intensive care unit (ORadj 1.5, 95% CI 1.0–2.3) and newborn hypoglycaemia (ORadj 3.4, 95% CI 1.8–6.4). In small for gestation (SGA) neonates, the risk of hypoglycaemia was further increased (OR 14.6, 95% CI 3.4–58.0). Similar analyses were made with free β‐hCG, but no statistically significant associations were found.ConclusionsLow first‐trimester serum PAPP‐A was associated with increased neonatal morbidity in post‐date pregnancies, particularly in newborns with SGA. Thus, PAPP‐A may qualify the timing of induction of labour in these pregnancies. © 2013 John Wiley & Sons, Ltd.
Sensitivity of cloud‐resolving precipitation simulations to uncertainty of radiation calculation: Effects of large‐scale forcing
Authors: Ran Lingkun , Li Xiaofan 
Published: June 2013

AbstractThe sensitivity of precipitation simulations to the uncertainty of radiation calculation is examined through the analysis of two sets of sensitivity experiments imposed by large‐scale forcing from weak tropical rainfall (weak forcing) and pre‐summer heavy rainfall events (strong forcing). Several simulations with perturbed solar and infrared radiative heating in different vertical layers are compared to a control simulation. In the weak‐forcing case, the precipitation simulation is more sensitive to the uncertainties of solar radiation calculation and less sensitive to the uncertainties of infrared radiation calculation in the lower troposphere than in the upper troposphere. In the strong‐forcing case, precipitation simulation is insensitive to the uncertainty of solar radiation calculation, but is more sensitive to the uncertainty of infrared radiation calculation in the lower troposphere than in the upper troposphere. The precipitation simulation is more sensitive to the uncertainty of radiation calculations in the weak‐forcing case than in the strong‐forcing case. Simulated precipitation sensitivity to perturbations in lower‐tropospheric radiative heating is associated with changes in water vapour convergence and condensation. The analysis of root‐mean‐squared difference and standard deviation shows that the root‐mean‐squared differences are similar in the two cases, but the increased magnitude in upward motion significantly causes a large rainfall fluctuation and also causes a larger standard deviation in the strong‐forcing case than in the weak‐forcing case. As a result, the increase in magnitude of upward motions leads to a decrease in the sensitivity of the precipitation simulation to the uncertainty of radiation calculation.
Microphysical properties of cold frontal rainbands†
Authors: Crosier J. , Choularton T. W. , Westbrook C. D. , Blyth A. M. , Bower K. N. , Connolly P. J. , Dearden C. , Gallagher M. W. , Cui Z. , Nicol J. C. 
Published: June 2013

AbstractObservations have been obtained within an intense (precipitation rates > 50 mm h−1) narrow cold‐frontal rainband (NCFR) embedded within a broader region of stratiform precipitation. In situ data were obtained from an aircraft which flew near a steerable dual‐polarisation Doppler radar. The observations were obtained to characterise the microphysical properties of cold frontal clouds, with an emphasis on ice and precipitation formation and development.Primary ice nucleation near cloud top (−55°C) appeared to be enhanced by convective features. However, ice multiplication led to the largest ice particle number concentrations being observed at relatively high temperatures (> −10°C). The multiplication process (most likely rime splintering) occurs when stratiform precipitation interacts with supercooled water generated in the NCFR. Graupel was notably absent in the data obtained.Ice multiplication processes are known to have a strong impact in glaciating isolated convective clouds, but have rarely been studied within larger organised convective systems such as NCFRs. Secondary ice particles will impact on precipitation formation and cloud dynamics due to their relatively small size and high number density. Further modelling studies are required to quantify the effects of rime splintering on precipitation and dynamics in frontal rainbands. Available parametrizations used to diagnose the particle size distributions do not account for the influence of ice multiplication. This deficiency in parametrizations is likely to be important in some cases for modelling the evolution of cloud systems and the precipitation formation. Ice multiplication has significant impact on artefact removal from in situ particle imaging probes.
Study on effects of scan parameters on the image quality and tip wear in AFM tapping mode
Authors: Xue Bo , Yan Yongda , Hu Zhenjiang , Zhao Xuesen 
Published: June 2013

SummaryDue to the tip‐sample interaction which is the measurement principle of Atomic Force Microscope (AFM), tip wear constantly occurs during scanning. The blunt tip caused by the wear process makes more tip geometry information involved in the image, and correspondingly it increases the measurement error. In the present study, the scan parameters of AFM in tapping mode which affect the wear of single crystal silicon tips, such as the approaching rate, the scan rate, the scan amplitude, and the integral gain are investigated. By proposing a parameter reflecting the imaging quality, the tip state tracing the sample surface is evaluated quantitatively. The influences of scan parameters on this imaging quality parameter are obtained by experiments. Finally, in order to achieve the perfect images with little tip wear influence, tip wear experiments are carried out and then the optimal parameter settings which can lighten the tip wear are obtained. SCANNING 36:263–269, 2014. © 2013 Wiley Periodicals, Inc.
Targeted Liposome‐Loaded Microbubbles for Cell‐Specific Ultrasound‐Triggered Drug Delivery
Authors: Geers Bart , De Wever Olivier , Demeester Joseph , Bracke Marc , De Smedt Stefaan C. , Lentacker Ine 
Published: June 2013

AbstractOne of the main problems in cancer treatment is disease relapse through metastatic colonization, which is caused by circulating tumor cells (CTCs). This work reports on liposome‐loaded microbubbles targeted to N‐cadherin, a cell–cell adhesion molecule expressed by CTCs. It is shown that such microbubbles can indeed bind to N‐cadherin at the surface of HMB2 cells. Interestingly, in a mixture of cells with and without N‐cadherin expression, binding of the liposome‐loaded microbubbles mainly occurs to the N‐cadherin‐expressing cells. Importantly, applying ultrasound results in the intracellular delivery of a model drug (loaded in the liposomes) in the N‐cadherin‐expressing cells only. As described in this paper, such liposome‐loaded microbubbles may find application as theranostics and in devices aimed for the specific killing of CTCs in blood.
Visible‐Light‐Induced Disruption of Diselenide‐Containing Layer‐by‐Layer Films: Toward Combination of Chemotherapy and Photodynamic Therapy
Authors: Ren Huifeng , Wu Yaoting , Li Yang , Cao Wei , Sun Zhiwei , Xu Huaping , Zhang Xi 
Published: June 2013

AbstractA photoresponsive polyelectrolyte multilayer film containing a diselenide functional group is fabricated using an unconventional layer‐by‐layer method. The polycation backbone is constructed through copolymerization of di‐(1‐hydroxylundecyl) diselenide and 1,4‐bis(2‐hydroxyethyl)piperazine with 2,4‐diisocyanatotoluene. A common polyanion poly(styrene sulfonate) is selected as the polyanion. The obtained film can be gradually disrupted under the irradiation of mild visible light, and this process can be monitored with UV–vis spectroscopy. The residue of the film is estimated to be 17% after 5 h of irradiation. The intensity of the visible light can be as low as 50 mW cm−2, which is even weaker than the sunlight. The cytotoxicity of the building blocks is evaluated in MTT assays using human hepatic cell line (L‐02), and the results are satisfactory. Further tests show that cells can grow in a regular manner on this film, indicating good biocompatibility. In addition, the film can be used to achieve cargo loading and controlled release. Considering that light can not only trigger controlled release but also act as part of the therapy itself (photodynamic therapy), this system shows hope for further development into a platform for the combination of chemotherapy and photodynamic therapy, especially for applications concerning skin.
Leichtbau 3.0: Material, Struktur, Energie
Authors: Englhardt Oliver 
Published: June 2013

AbstractLeichtbau im Bauwesen bedeutet grundsätzlich das Streben nach Konstruktionen mit einem minimalen Gewicht bei optimaler Ausnutzung der Werkstoffeigenschaften. Dieses wird zukünftig durch eine maximale Reduzierung des gesamtenergetischen Beitrags bzw. des kumulierten Energieaufwands ergänzt. Am Beispiel hybrider Hüllkonstruktionen wird diese Entwicklung zum Leichtbau 3.0 aufgezeigt. Neben dem Heranziehen sämtlicher Bauteile für den lastabtragenden Einsatz sind hier besonders funktionale Anforderungen aus der Hochbautechnologie zu lösen. Das Flächentragverhalten der Glaselemente, die zugehörigen Lasteinleitungsmechanismen und Randbedingungen sind hierbei von besonderer Bedeutung. Die Konzepte des Leichtbaus sind dabei Grundlage ganzheitlichen Entwickelns und Konstruierens. Das Beispiel zeigt, dass die Fassade als Teil unserer Infrastruktur neue Möglichkeiten für weitere Entwicklungen und Innovationen im Engineering für das Bauwesen bietet.Leichtbau 3.0: material, structure, energy. Lightweight constructions basically mean the striving to design structures with a minimal weight compared with a full use of the material properties. In future this has to be complemented by a maximum reduction of the cumulative energy demand (amount of energy consumed over the whole lifetime) for structures. The example of the development of a hybrid building envelope will demonstrate that evolution of the so‐called Leichtbau 3.0. Each component of the structure has to act as a load‐bearing member and has to fulfil the functional requirements of a building envelope at the same time. In this respect, the use of the glass elements as surface structures, the load transmission and the boundary conditions become particularly important. The concepts of lightweight construction are the basic principles of a holistic development and design in building construction. The example shows that façades and building envelopes as part of our infrastructure are offering new development opportunities and innovations in structural engineering and design.
Anwendungsbeispiele zur Optimierung verformungsempfindlicher Tragwerke
Authors: Sundermann Wolfgang , Eilbracht Gert , Holzinger Christoph 
Published: June 2013

AbstractVerformungsempfindliche Tragwerke benötigen wesentliche Anteile ihres Materials zur gezielten Erhöhung der Steifigkeit hinsichtlich verformungskritischer Punkte, wie z. B. die Feldmitte bei Brückentragwerken oder der Kopfpunkt bei Hochhaustragwerken. Insbesondere bei komplexen Strukturen stößt eine nur händische vorgenommene Optimierung solcher Tragwerke schnell an ihre Grenzen. Die hier angewandte Methode der Verformungsreduzierung durch Materialumverteilung (MVM) bietet ein praxistaugliches Instrument, um die Materialmengen innerhalb eines geometrisch festgelegten Tragwerkes so umzulagern, dass die für die kritische Verformung wichtigen Stäbe mehr Material erhalten. Dabei bleibt die Gesamtmasse des Tragwerkes erhalten. Die im Text dargestellten Beispiele einer Stahl‐Fachwerkbrücke und einer Stahl‐Glas‐Dachkonstruktion als Gitterrost zeigen die Möglichkeiten des praktischen Einsatzes dieser Optimierungsmethode auf.Application studies to optimize deformation sensitive structures. Many building structures are designed in such a way that the deflection in a critical point of the structure is reduced as much as possible (e. g. the middle span of a bridge or the top level of a high rise building). This often requires a lot of material. In addition optimizing these kinds of structures by hand is quite difficult and time consuming. This article demonstrates the practical usage of an optimization method (called MVM), which allows an engineer to redistribute the material within a geometrically given structure in such a way that the deflection in a critical point is reduced as much as possible. The demonstrated case studies are a steel truss bridge over four spans and a steel roof structure for a bus station.
Tetsuo Nozoe's “Autograph Books by Chemists 1953–1994”: An Essay
Authors: Nakanishi Koji 
Published: June 2013

Note from the Editor:It is with special pleasure and a warm feeling of gratitude that I introduce Koji Nakanishi's essay which accompanies the publication of the fifth segment of the Tetsuo Nozoe Autograph Books. This project, “Bonding beyond Borders,” is a symbol of the ever‐increasing connectivity among the many members of the chemistry community. Both Nakanishi and Nozoe wrote autobiographies in the Profiles, Pathways and Dreams series that I edited from 1985 to 1997. I learned from their books how close they were as friends and as colleagues. My interest in publishing the Nozoe Autograph Books goes back many years but was stymied by the difficulty of finding a publisher. This interest was rekindled when, in 2006, Nakanishi told me about – and eventually lent me – a one volume specially printed commemorative collection of the Nozoe Autograph Books. At an ACS National meeting, I rushed to show this book to Eva Wille who could not put it down. This was the entry, the personal connection, that led to the publication of the Nozoe Autograph Books by Wiley‐VCH in The Chemical Record. This is another example of bonding, of enthusiasm and commitment, within our community.Jeffrey I. Seeman Guest Editor,University of RichmondRichmond, Virginia 23173, USA
Electroencephalogram‐sleep study
Authors: Piryatinska Alexandra 
Published: June 2013

The study of sleep, and in particular electroencephalogram (EEG)‐sleep recordings, is important in several areas of medicine. Next to pain, sleep anomalies are the most significant indicators of illness. During sleep the human brain goes through several physiological stages; therefore, the problem of automated detection of sleep stages usingEEGdata naturally arises in neurosciences. A two step procedure of computerized scoring of sleep stages is considered, with the first step involving features extractions via spectral and nonlinear dynamics characteristics and the second step in which sleep classifications can be accomplished.WIREs Comput Stat2013, 5:326–333. doi: 10.1002/wics.1261This article is categorized under:Statistical Learning and Exploratory Methods of the Data Sciences > Clustering and ClassificationApplications of Computational Statistics > Health and Medical Data/InformaticsApplications of Computational Statistics > Signal and Image Processing and CodingData: Types and Structure > Time Series, Stochastic Processes, and Functional Data
Experimental QTAIM Analysis of the Electron Density in TiB2
Authors: Terlan Bürgehan , Akselrud Lev , Baranov Alexey I. , Borrmann Horst , Grin Yuri 
Published: June 2013

AbstractTopological aspects of the experimental electron density in TiB2reconstructed on base of the multipole model are obtained from high‐resolution single‐crystal X‐ray diffraction data. The features of electron density are compared with quantum chemical calculations and analysed in terms of Quantum Theory of Atoms in Molecules for the interpretation of atomic interactions. In spite of some differences in the Laplacian, both experimental and calculated density confirmed two main bonding interactions. The B–B bond critical point suggests a shared‐type interaction with pronounced ellipticity in the boron layer, whereas B–Ti bond critical point reveals an interaction intermediate between shared and closed‐shell type. Both, theory and experiment indicate a non‐structured spherical topology in the penultimate shell of Ti. Integration of the electron density over the atomic basins reveals a charge transfer of 1.1 e (experiment) and 1.4 e (theory) from titanium to boron network, respectively.
Variable Coordination Modes of Potentially Tetradentate Phosphino‐ and Arsinoarylthiolato Ligands Derived from E(2‐SHC6H4)3 (E = P, As) in Gallium(III) Complexes
Authors: Vălean Ana‐Maria , Gómez‐Ruiz Santiago , Silaghi‐Dumitrescu Luminita , Hey‐Hawkins Evamarie 
Published: June 2013

AbstractP(2‐SHC6H4)3 (PS3H3) reacts with GaMe3 (1:1) to give GaMe{P(2‐SC6H4)2(2‐SHC6H4)‐κ3S,S′,P} (1), which could be deprotonated with NEt3 to give [NEt3H][GaMe{P(2‐SC6H4)3‐κ3S,S′,P}] (2). The 1:2 reaction of E(2‐SHC6H4)3 [E = P (PS3H3), As (AsS3H3)] with GaMe3 gave the dinuclear complexes GaMe{E(2‐SC6H4)2(2‐S{GaMe2(THF)}C6H4)‐κ3S,S′,E} [E = P (3), As (4)]. Serendipitous hydrolysis of 4 resulted in small amounts of the hexanuclear gallium hydroxide complex cyclo‐{GaMe(μ‐OH)}6{As(2‐SC6H4)3‐κS,S′,S′′}2 (5). Complexes 1–4 were fully characterized, complexes 2–5 also by X‐ray crystallography.