bluuebunny/crossref_metadata_2025_split huggingface dataset:
Quantized electrode for robust organic devices
Authors: Lu Zheng-Hong , Shi Changsheng , Chen Nan , Zhong Cheng , Tang Lianhua , Zhang Dongming , Man Jia-Xiu , Wang Dengke , Ding Huaiyi , Zhao Yong-Biao , Ning Sun 
Published: August 2024

Abstract

The contact between inorganic electrodes and organic layers serves as both a charge-carrier conduit and a crucial topological link in organic optoelectronic devices, significantly impacting carrier injection/extraction efficiency and long-term stability. A barrier-free contact for hole injection with thermodynamic stability at the inorganic electrode/organic interface is essential for efficient devices. However, this has not yet been realized between metal electrodes and organic materials with high ionization energy (IE). Here we demonstrate a quantized electrode with surface charge-transfer states formed by chemisorbed ultrathin organic layer on an aluminum surface. This quantized electrode, featuring a new injection mechanism, forms universal ohmic hole contacts with organic semiconductors possessing high IEs up to 6.1 eV, rendering the conventional rule of ohmic hole contact that the work function of the anode must match the IE of the organic semiconductor invalid. The resultant organic light-emitting diode (OLED) achieves ultrahigh luminance at low voltage and extremely low efficiency roll-off. Moreover, the quantized electrode exhibits excellent thermal stability, with a seventeen-fold increase in operational lifetime compared to the reference device. Quantized electrodes will facilitate the development of OLED microdisplays and have potential applications in other advanced semiconductors requiring ohmic hole contact and robust stability.
AWARENESS OF BREAST CANCER RISK FACTORS AMONG FINAL-YEAR
RADIOGRAPHY STUDENTS IN NORTHERN NIGERIA
Authors: Abubakar Auwal , Kolo Abubakar Mustapha , Anas Alyasaa 
Published: August 2024

Abstract

Breast carcinoma is the leading cause of death among women aged 30 and above, significantly reducing life expectancy, particularly for those between 31 and 50 years old. The incidence of breast cancer is rapidly increasing in population groups that previously had low rates of the disease. A major concern is that most patients present late to the hospital, primarily due to inadequate knowledge of breast cancer among the general population. Therefore, it is crucial to assess the level of awareness and knowledge of breast cancer risk factors. This study aimed to evaluate the awareness of breast cancer risk factors among final-year Radiography students in Northern Nigeria. A cross-sectional survey was conducted among students from three universities in Northern Nigeria, using self-administered questionnaires. Of the respondents, 158 (96.3%) had heard of breast cancer, with 69 (42.1%) citing lectures as their primary source of information. However, overall knowledge of breast cancer risk factors was found to be low. In conclusion, while the majority of respondents were aware of breast cancer, their knowledge and understanding of the disease and its risk factors were notably deficient.
Optimization of Combustion and Emission Parameters in LHR Engines Using Mahua Oil Biodiesel
Authors: Gabiriel Deepika 
Published: August 2024

Abstract

The study investigates the performance, combustion, and emission characteristics of Mahua oil in a low heat rejection (LHR) diesel engine with retarded injection timing. Mahua oil, a non-edible biodiesel, was evaluated against conventional diesel in both coated and uncoated engine configurations. The engine coated with partially stabilized zirconia (PSZ) showed significant improvements. Brake thermal efficiency (BTE) increased by 9.15%, and specific fuel consumption decreased by 6.23% compared to the standard uncoated engine. Emission analysis revealed a reduction in carbon monoxide (CO) and unburnt hydrocarbons (UBHC) by 20.35% and 12.28%, respectively. However, nitrogen oxide (NOx) emissions increased by 5.36% due to the higher combustion temperature induced by the PSZ coating. Exhaust gas temperature (EGT) also rose by 18.64%, highlighting enhanced combustion. The study concludes that Mahua oil, when used in an LHR engine with retarded injection timing and PSZ coating, offers improved efficiency and reduced emissions, making it a viable alternative to diesel in specific applications. Future work should explore the effects of varying compression ratios and different biodiesel blends to optimize engine performance further.
ANÁLISE DO FATOR BIOPSICOSSOCIAL- EVOLUÇÃO NA QUALIDADE DE VIDA EM PACIENTES DIABÉTICOS
Authors: Hamann Aquilles Henrique Garcia , Vilela Ighor Alessandro Muraro , Sobrinho Pablo Vinicius Moraes de Sousa , Pureza Danilo Dheyvison Nascimento 
Published: August 2024

O Diabetes Mellitus tipo 2 (DM2) é uma doença crônica não transmissível que acomete atualmente cerca de 12,5 milhões de brasileiros, estando o país em quarto lugar no ranking de maior incidência. Portanto, o objetivo deste artigo é analisar as principais formas de modificação na qualidade de vida dos pacientes portadores de diabetes mellitus tipo 2. Trata-se de uma revisão integrativa da literatura, para realização das pesquisas serão utilizadas as bases de dados: Scielo, Web of science e Biblioteca Virtual em Saúde (BVS/MEDLINE). O diabetes exerce um impacto negativo na percepção dos pacientes sobre sua qualidade de vida. A terapia combinada entre metformina e atividade física melhorou a capacidade funcional e os níveis de hemoglobina glicada (HbA1c), em relação à terapia isolada, sendo considerados pilares no tratamento e importantes para a prevenção das complicações geradas pelo DM2. Além disso, o uso de insulina demonstra uma pontuação menor nos escores do componente mental, melhorando a qualidade de vida do paciente. Portanto, torna-se necessária a realização de novos estudos a respeito das alterações na qualidade de vida em relação ao tempo de tratamento, a fim de aplicar as melhores intervenções em cada etapa de adaptação, gerando qualidade de vida para esses pacientes, e garantindo uma assistência integral à saúde.
Machine Learning Prediction and Simulation of Drugs Targeting GSK-3β in Breast Cancer
Authors: Munieswaran Gayatri , Subramani Nandha Kumar , Venugopal Subhashree 
Published: August 2024

Introduction and Objective:
Breast cancer ranks as the second-most prevalent cause of
death among women worldwide, with particularly elevated mortality rates in India. Breast cancer’s
origin involves biochemical pathway alterations influenced by tumor-inducing proteins. Research
has highlighted glycogen synthase kinase-3 beta (GSK-3β) as a crucial protein that regulates
the expression of various genes in the cell cycle. Mutations in this protein have a significant
impact on cellular development. As a consequence, it triggers aggressive subtypes of breast cancer,
such as triple-negative breast cancer. So, the primary aim of this study is to identify novel
chemicals targeting GSK-3β using machine learning methods, molecular modeling, and dynamic
techniques.

Materials and Methods:
To achieve the study's objective, small molecules were screened using a
Machine Learning (ML) approach, and subsequently, molecular docking and dynamic modelling
investigations were conducted to explore interactions between drugs and GSK-3β.

Results:
The research findings highlighted a specific compound, piperidine, 4-(3,4-
dichlorophenyl)-4-[4-(1H-pyrazol-4-yl) phenyl], which exhibited a superior docking score of -9.6
kcal/mol. Piperidine also formed conventional hydrogen bonds with the target protein. Furthermore,
the calculated binding free energy of -12.46 kcal/mol suggested that this compound exhibited
greater stability compared to commercially available drugs.

Conclusion:
These promising findings highlight the potential of piperidine and similar small
molecules as promising candidates for targeting the tumor-inducing protein GSK-3β. Subsequent
investigations, both in vitro and in vivo, will be essential to assess their effectiveness in combating
breast cancer.
Long-Term Use of Metformin and Vitamin B12 Deficiency in Diabetes
Authors: Hussain Md Sadique , Srivastava Nitya , Singh Gurvinder , Kumar Rajesh 
Published: August 2024

Abstract:
This extensive review delves into the complex relationship between prolonged use of
metformin and the possible emergence of vitamin B12 deficiency (VB12D) in diabetic patients.
Metformin, a pivotal element in diabetes management, is constantly linked with decreased absorption
of vitamin B12, prompting concerns about the enduring consequences of this interaction.
The review systematically amalgamates current evidence, elucidating the prevalence,
mechanisms, and clinical ramifications of VB12D induced by consistent consumption of metformin.
Exploring the different pathways through which metformin might disrupt the absorption
of Vitamin B12, the review encompasses interference with the calcium-dependent membrane activity
and alterations of the microbiota present in the gut. A meticulous analysis of experimental
studies and human trials is undertaken, accentuating the prevalence of variable VB12D among
individuals on long-duration treatment of metformin across diverse populations and age groups.
Clinical indications of cobalamin deficiency, spanning haematological abnormalities to neurological
complications, are systematically examined. Furthermore, the review delves into the potential
implications of cobalamin deficiency associated with metformin on diabetes-related complications
and overall patient health. This review offers a comprehensive overview of the intricate
interplay between the use of metformin and deficiency of vitamin B12 in diabetic patients,
emphasizing the importance that lies in routine monitoring, early detection, and personalized interventions
to optimize the long-period safety and efficiency of metformin in the treatment of diabetes.
It also proposes future research directions to refine clinical guidelines and enhance the
understanding regarding the correlation between diabetes, metformin, and vitamin B12.
The Protective Effects of Mito-TEMPO on Acetaminophen-induced Hepatotoxicity: A Systematic Review
Authors: Jamshidi Hamid Reza , Saadati Mahdi , Saghafi Fatemeh 
Published: August 2024

Background:
Acetaminophen overdose is a leading cause of acute liver failure glob-ally. Current treatment options, primarily N-acetylcysteine (NAC), have limitations. Mito-TEMPO (Mito-T), a mitochondria-targeted antioxidant, has shown potential in preclinical stud-ies. This systematic review evaluated the evidence for Mito-T's hepatoprotective effects against acetaminophen-induced liver injury.

Methods:
We conducted a comprehensive search of databases and grey literature following PRISMA guidelines. Studies published between 2000 and 2023 on Mito-T and acetaminophen-induced hepatotoxicity in animal models were included. Data on study characteristics, inter-ventions, outcomes, and risk of bias were extracted.

Results:
Six high-quality studies were included. Mito-T administration significantly reduced serum alanine transaminase (ALT) levels, a marker of liver injury, compared to controls. Mito-T also protects against hepatocellular necrosis, apoptosis, and mitochondrial dysfunction. These effects were likely mediated by Mito-T's ability to scavenge reactive oxygen and nitrogen spe-cies within mitochondria.

Conclusion:
This review provides strong evidence that Mito-T effectively protects against ac-etaminophen-induced liver injury in animal models. Mito-T’s mechanisms of action address a critical pathophysiological pathway in acetaminophen toxicity. While limitations, including the use of animal models and potential for publication bias, exist, the findings suggest Mito-T holds promise as a novel therapeutic option. Further studies are needed to assess Mito-T's safety, pharmacokinetics, and optimal dosing in humans. Clinical trials comparing Mito-T against NAC are warranted if toxicity profiles are favorable. Additionally, investigating Mito-T's po-tential in other diseases involving oxidative stress is crucial.
PERUBAHAN PERILAKU KONSUMSI PADA MASYARAKAT JAWA TIMUR SELAMA MASA PANDEMI COVID-19
Authors: Arina Sofi Ulya  , Dwi Budi Santoso  
Published: August 2024

The COVID-19 pandemic that occurred in various countries affected almost all aspects of life, one of which was community activities. The existence of social restriction policies has a direct impact on the decline of economic activity, which has the opportunity to change people's consumption behavior. Consumption behavior is the activity of spending income to maximize utility. This study aims to determine changes in consumption behavior in the people of East Java during the COVID-19 pandemic. The method used is a classy typology model to see changes in consumption in 2019 and 2020. Then, it was analyzed using the COVID-19 risk index in each region. The results showed that the changes in consumption that occurred in East Java were influenced by the COVID-19 risk index, areas that have a high risk index tend to experience changes in consumption and vice versa. The changes in behavior that occur due to covid-19 risk factors vary in each region so that changes occur in the proportion of consumption of goods/services and changes in savings rates. This research can assist the government in taking economic recovery policies after the COVID-19 pandemic in each region by looking at the COVID-19 risk index.
Burnout Pada Perawat di Ruang Rawat Inap di Rumah Sakit: Studi Deskriptif
Authors: Fatimah Fatma Siti , Yugistyowati Anafrin 
Published: August 2024

<p align="justify">Perawat yang bekerja di rawat inap mempunyai tantangan serta tanggungjawab yang berkelanjutan sehingga dapat menyebabkan stres selama bekerja menyebabkan kelelahan secara emosional dan fisik atau burnout. Penelitian ini bertujuan untuk mengetahui gambaran burnout pada perawat di rawat inap. Desain penelitian ini deskriptif analitik dengan pendekatan cross sectional. Penelitian dilakukan di Teknik sampel yang digunakan yaitu nonprobability sampling dengan jenis total sampling. Sampel dalam penelitian ini berjumlah 85 responden. Penelitian dilaksanakan di Rumah Sakit Dr. Soetarto Yogyakarta. Penelitian dilaksanakan pada bulan Juni tahun 2022. Alat ukur instrument yang digunakan yaitu kuesioner burnout. Uji statistik yang digunakan adalah univariat. Hasil penelitian menunjukkan Penelitian ini dapat disimpulkan burnout perawat di ruang rawat inap mayoritas dalam kategori sedang yaitu sebesar 57 (67.1%) perawat. Sehingga hal ini perlu perhatian khusus dari manajemen Rumah Sakit untuk mengatasi burnout sehingga kinerja perawat menjadi optimal.</p><p align="justify"> </p><p align="justify"><strong>K</strong><strong>a</strong><strong>t</strong><strong>a</strong><strong> </strong><strong>K</strong><strong>un</strong><strong>c</strong><strong>i</strong><strong>:</strong><strong> </strong>Burnout; Kelelahan kerja; Perawat</p>
The effect of multiple trauma with rhabdomyolysis-induced acute kidney injury on the functional state of main body systems
Authors: Dubyna V.M. , Kravets O.V. 
Published: August 2024

Background. Traumatic injuries often lead to rhabdomyolysis, the destruction of muscle tissue, which causes leakage of the intracellular contents of myocytes into the bloodstream. The most common systemic complication of rhabdomyolysis is acute kidney injury (AKI). It occurs with a frequency of 10 to 55 % and is associated with a poor prognosis, especially with multiple organ failure. The aim of our work was to investigate the impact of multiple trauma complicated by rhabdomyolysis and AKI on the state of the body’s main systems. Materials and methods. We examined 96 victims with multiple trauma complicated by rhabdomyolysis and AKI. Upon admission, we examined the frequency of vasopressor support, rate of diuresis, indicators of the blood count, biochemistry (hepatic, renal complex, electrolytes, creatine kinase, myoglobin), coagulogram, acid-base and gas composition of blood. Results. Severe multiple trauma caused a massive rhabdomyolysis with an increase in creatine kinase to 7058.3 ± 2726.2 units/l, myoglobin to 1433.1 ± 121.9 μg/l. The mean empirical blood loss volume was 2762.5 ± 363.4 mL, leading to posthemorrhagic anemia and thrombocytopenia. 56.3 % of victims needed vasopressor support. Stress hyperglycemia up to 9.2 ± 1.7 mmol/l was observed. Liver dysfunction manifested by a decrease in total protein to 45.3 ± 2.3 g/l, albumin to 26.9 ± 1.5 g/l, which created a risk of interstitial edema. A significant cytolytic syndrome was formed with an increase in alanine aminotransferase to 466.5 ± 141.4 U/l, aspartate aminotransferase to 822.9 ± 187.9 U/l. Moderate hypocoagulation was observed with a decrease in the prothrombin index to 74.6 ± 4.3 % and an increase in the international normalized ratio to 1.4 ± 0.1; activated partial thromboplastin time and fibrinogen level remained within normal limits. The inflammatory reaction manifested by leukocytosis up to (15.3 ± 1.3) × 109/l. AKI was accompanied by an increase in creatinine to 402.1 ± ± 58.6 μmol/l, urea to 19.9 ± 3.0 mmol/l. Diuresis on the first day after admission averaged 0.47 ± 0.08 ml/kg/h. Hyperkalemia was observed in 47.2 % of victims: in 26.5 % of cases, potassium level was from 5.5 to 6.5 mmol/l, in 13.2 %, from 6.5 to 7.5 mmol/l, in 7.5 %, more than 7.5 mmol/l. These disorders were accompanied by subcompensated mixed acidosis. Conclusions. Multiple trauma complicated by rhabdomyolysis and acute kidney injury forms multiple organ failure with a high frequency of vasopressors need, post-hemorrhagic anemia, stress hyperglycemia, impairment of protein synthetic, pigment, enzymatic functions of the liver, coagulopathy, inflammatory syndrome, mixed acidosis and kidney damage per se, which manifested by oliguria, hyperazotemia and hyperkalemia.
GAMBARAN TINGKAT KEPUASAN IBU HAMIL SEBAGAI PENGGUNA APLIKASI ANCY-CARE DI KOTA YOGYAKARTA
Authors: Sari Okky Nurlita 
Published: August 2024

ANCY-Care application (Anemia in Pregnancy-Care), a media that can be used by users find information about anemia of pregnancy can be accessed with Android-based telephone. In knowing extent to which information systems or media be said succeed, End-User Computing Satisfaction (EUCS) is a method for measuring level of satisfaction of users an application system. The type of research used is descriptive method research with cross-sectional design. The sample in this study were 41 pregnant women who used the ANCY-Care application March-May 2019 in Yogyakarta City. This study used the End-User Computing Satisfaction (EUCS) model instrument that had been translated into Indonesian which had validity and reliability. This research has obtained the ethical feasibility of the research from the Ethics Committee Nursing Faculty of Medicine, Public Health, and Nursing Gadjah Mada University (KE/FK/1365/EC/2018). The overall level of user satisfaction is at an average value of 3.18 while the average value for each EUCS dimension is content dimension 3.12; accuracy dimensions 3.16; format dimensions 3.24; ease of use dimensions 3.20 and timeliness dimension 3.16. Users in generally satisfied in the use of the ANCY-Care application, while for user satisfaction each dimension is at the satisfied level.
STUDI KASUS PEMBIAYAAN PELAKSANAAN PROGRAM TUBERKULOSIS SAAT PANDEMI COVID-19 DI KOTA MEDAN
Authors: Sitorus Syafriana , Mahendradhata Yodi , Kurniawan Faozi 
Published: August 2024

Tuberkulosis (TB) masih menjadi penyakit global dengan tingkat morbiditas dan mortalitas dan yang tinggi (1,2 juta meninggal tahun 2019). Selain itu, dunia justru dihadapkan dengan permasalahan kesehatan baru yaitu coronavirus disease 2019 (COVID-19) yang mempengaruhi semua sektor kesehatan termasuk di Indonesia. Kota Medan memiliki kasus COVID-19 yang tinggi (90.717 kasus dengan 2.166 meninggal dunia). Peningkatan kasus COVID-19 memberikan dampak terhadap cakupan penemuan kasus dan keberhasilan pengobatan TB (35,2% dari target 65% tahun 2020). Adanya refocusing anggaran pengendalian TB menghambat realisasi pengadaan dan kegiatan yang telah direncanakan. Pelayanan TB di fasilitas kesehatan juga terganggu. Tujuan Penelitian ini untuk menganalisis pembiayaan pelaksanaan program Tuberkulosis saat adanya pandemi COVID-19 di Kota Medan.Penelitian menggunakan studi kasus dengan single case design (embedded) di Dinas Kesehatan Kota Medan dan BPJS Kesehatan Kota Medan. Subjek penelitian berjumlah 8 orang yang dipilih menggunakan teknik purposive sampling. Pengumpulan data lainnya lainnya dengan enam sumber bukti, yaitu dokumenentasi arsip, wawancara terfokus dan open- ended, observasi langsung, dan perangkat fisik. Data tersebut dianalisa menggunakan teknik pattern matching dan analisa deret waktu.Pembiayaan program TB saat pandemi COVID-19 tahun 2020 dan 2021 bersumber dari APBN, Global Fund Kemenkes, APBD Provinsi dan Kota, dan sektor swasta (USAID-TBPS, YKI, STPI – Penabuluh, dan sektor swasta lainnya). Pembiayaan tersebut mengalami refocusing anggaran di tahun 2021 yang menyebabkan beberapa kegiatan tidak bisa berjalan optimal, namun tahun 2021 adanya peningkatan sumber pembiayaan program TB. Sedangkan pembiayaan klaim INA CBG’s di rumah sakit untuk program TB juga mengalami penurunan tahun 2020 dan 2021. Sementara Pelaksaanan program TB saat adanya pandemi COVID-19 di Kota Medan mengalami beberapa kendala baik dari penjaringan TB, diagnosis TB dan pengobatan TB. Keterlibatan lintas sektor dalam setiap tahapan tersebut sejak tahun 2021 membuat pelaksanaan menjadi lebih optimal dalam upaya menguatkan sistem kesehatan baik di faskes primer maupun rujukan. Selain itu, pencapaian indikator angka penemuan kasus mengalami penurunan secara drastis dari sebelum adanya COVID-19. Angka Notifikasi Kasus yaitu 213 per 100.000 penduduk (2020) dan 206 per 100.000 penduduk (2021). Sementara Success Rate TB tidak terlalu terdampak telah mencapai 90%.
Pengaruh Efikasi Diri Dan Ajaran Tri Nga Terhadap Niat Berkarir Di Bidang Perpajakan
Authors: Wardani Dewi Kusuma , Murni Vinsensiana Desinoel 
Published: August 2024

Penelitian ini berusaha untuk mengetahui bagaimana efikasi diri dan ajaran Tri Nga mempengaruhi niat untuk mengejar karir di bidang perpajakan. Data primer dikumpulkan dengan menyebarkan kuesioner kepada mahasiswa akuntansi yang terdaftar di Universitas Sarjanawiyata Tamansiswa menggunakan platform Google Form. 100 orang mengambil bagian dalam penelitian secara keseluruhan. Para peneliti menggunakan convenience sampling, sebagai metode pengambilan sampel. Teknik analisis regresi linier berganda diterapkan dengan hati-hati pada data untuk menganalisisnya. Temuan penelitian menunjukkan bahwa variabel keyakinan efikasi diri tidak berpengaruh pada niat seseorang untuk berkarir di bidang perpajakan, sementara ajaran tri nga berpengaruh positif terhadap niat berkarir di bidang perpajakan.
Pemanfaatan Tepung Daun Katuk (Sautopus Androgynus L. Merr) Menjadi Produk Cendol
Authors: Handayani Shintia Arum , Ekayani Ida Ayu Putu Hemy , Sukerti Ni Wayan 
Published: August 2024

Penelitian ini bertujuan untuk mengetahui mutu organoleptik cendol dengan penambahan tepung daun katuk yang dapat dilihat dari aspek warna, rasa, dan tekstur. Jenis penelitian ini adalah penelitian deskriptif kuantitatif dengan metode eksperimen. Metode pengumpulan data dalam penelitian ini adalah metode observasi untuk mengetahui kualitas produk cendol tepung daun katuk yang dilihat dari aspek warna, rasa dan tekstur. Panelis yang digunakan yaitu panelis terbatas yang terdiri dari 4 orang dosen Program Studi Pendidikan Vokasional Seni Kuliner. Data yang diproleh kemudian dianalisis dengan teknik deskriptif kuantitatif. Hasil penelitian menyatakan bahwa cendol dengan pemanfataan tepung daun katuk sebesar 5% (1) pada aspek warna diproleh skor 2,00 dengan kategori “Cukup” yang menghasilakan warna yellowgreen (2) pada aspek rasa diperoleh skor 3 dengan kategori “Baik” yang menghasilkan cendol dengan rasa khas daun katuk (3) pada aspek tekstur diproleh skor 2,50 dengan kategori “Baik” yang menghasilkan cendol dengan tekstur kenyal dan padat. Kata Kunci : Tepung, Daun Katuk, Cendol