bluuebunny/crossref_metadata_2025_split huggingface dataset:
A DEAD‐box RNA helicase Ddx54 protein in oligodendrocytes is indispensable for myelination in the central nervous system
Authors: Zhan Rui , Yamamoto Masahiro , Ueki Toshiyuki , Yoshioka Nozomu , Tanaka Kayoko , Morisaki Hiromi , Seiwa Chika , Yamamoto Yuta , Kawano Hitoshi , Tsuruo Yoshihiro , Watanabe Kenji , Asou Hiroaki , Aiso Sadakazu 
Published: December 2012

AbstractWe recently reported that a new monoclonal antibody, 4F2, which labels oligodendroglial lineage cells, recognizes a DEAD‐box RNA helicase Ddx54 and that Ddx54 binds to myelin basic protein (MBP) in brain and cultured oligodendrocytes. To elucidate the biological function of Ddx54, we generated a recombinant adenovirus, Ad‐shRNA:Ddx54, expressing a short hairpin RNA to silence endogenous Ddx54 protein. The virus was intraventricularly injected into the brains of mice on postnatal day (PD) 2. The brains at PD 9 were then analyzed by immunohistochemistry. In untreated normal brain sections, as well as control brains that had been injected with Ad‐β‐Gal, myelination of axons occurred in the corpus callosum with filamentous patterns of immunosignals of myelin‐associated glycoprotein (MAG) and MBP. In Ad‐shRNA:Ddx54‐injected brain, substantial amounts of MAG and MBP immunosignals were present, but MBP immunosignals accumulated in the subplate layer and did not intrude into the emerging white matter. Immunoblot analysis revealed that Ddx54 knockdown caused a significant decrease in the level of 21.5 kDa MBP isoform and Ddx54, but the amount of Olig2; 2′,3′‐cyclic nucleotide 3′ phosphodiesterase; MAG; three MBP isoforms (14, 17.5, and 18 kDa); and QKI‐5, QKI‐6, and QKI‐7 proteins remained unchanged. Transfection of the Ddx54 expression vector into luciferase reporter‐introduced neuroepithelial cells resulted in upregulated MBP promoter activity. Immunoprecipitation of Ddx54 protein in MBP‐transfected HEK293 cells indicated that Ddx54 may directly interact with MBP mRNA. These results suggest that Ddx54 protein play an important role in central nervous system myelination, presumably in myelin sheath formation after the differentiation of oligodendrocytes. © 2012 Wiley Periodicals, Inc.
Asymptomatic/pauci‐symptomatic creatine kinase elevations (hyperckemia)
Authors: Silvestri Nicholas J. , Wolfe Gil I. 
Published: December 2012

ABSTRACTNeuromuscular clinicians are frequently asked to evaluate patients referred for asymptomatic elevations in creatine kinase (CK), a catalytic enzyme that combines creatine and ATP to form phosphocreatine and ADP. This reaction is crucial for cellular energy generation and metabolism. This laboratory finding, often referred to in simplified lexicon as asymptomatic hyperCKemia, continues to generate controversy at several levels, including definition, the extent of evaluation, and the yield of diagnostic testing. In this review, we summarize the literature based on series of patients with asymptomatic hyperCKemia and provide a rational clinical approach to reveal identifiable underlying causes. Muscle Nerve 47: 805–815, 2013
An open trial of long‐term testosterone suppression in spinal and bulbar muscular atrophy
Authors: Yamamoto Tomotaka , Yokota Kazuhiko , Amao Rie , Maeno Takashi , Haga Nobuhiko , Taguri Masataka , Ohtsu Hiroshi , Ichikawa Yaeko , Goto Jun , Tsuji Shoji 
Published: December 2012

ABSTRACTIntroductionWe investigated the long‐term effects of leuprorelin on leg‐muscle strength in spinal and bulbar muscular atrophy (SBMA). We hypothesized that testosterone suppression by leuprorelin would prevent the progression of muscle weakness.MethodsIn a prospective, long duration, open trial, 16 SBMA patients underwent medical castration with leuprorelin for 3.5 years. Chlormadinone was coadministered initially to prevent a testosterone surge. The strength of knee extension and flexion were quantitated using a torque machine.ResultsOur hypothesis was rejected. The leg strength measures decreased significantly with the mean reduction of 22.3–27.8%. In a post hoc analysis, the leg strength of 4 patients with higher pretreatment baseline total testosterone levels and short disease duration of 1–6 years were stronger at baseline and decreased by only 12.3–15.7% after treatment.ConclusionsLeuprorelin was not effective in this small long‐term treatment trial in SBMA. The possibility that earlier treatment might be beneficial may deserve further study. Muscle Nerve 47: 816–822, 2013
Robust stability of singularly perturbed descriptor systems with uncertain Markovian switchings and nonlinear perturbations
Authors: Wang Guoliang , Zhang Qingling , Yang Chunyu 
Published: December 2012

SUMMARYThis paper is concerned with the problem of robust stability of Markovian jump singularly perturbed descriptor systems with uncertain switchings and nonlinear perturbations for any , where is a pre‐defined positive scalar. A linear matrix inequality (LMI) condition is firstly established to guarantee the existence and uniqueness of a solution. Then, an ε‐independent condition in terms of LMI related to is derived via using an ε‐dependent Lyapunov function, where the solution exists uniquely and is globally exponentially mean‐square stable simultaneously. Finally, numerical examples are used to show the feasibility and effectiveness of the given theoretical results. Copyright © 2012 John Wiley & Sons, Ltd.
Quantitative evaluation of the fetal cerebellar vermis using the median view on three‐dimensional ultrasound
Authors: Zhao Dan , Liu Wei , Cai Ailu , Li Jingyu , Chen Lizhu , Wang Bing 
Published: December 2012

ABSTRACTObjectiveThe purpose of this study was to investigate the effectiveness for quantitative evaluation of cerebellar vermis using three‐dimensional (3D) ultrasound and to establish a nomogram for Chinese fetal vermis measurements during gestation.MethodsSonographic examinations were performed in normal fetuses and in cases suspected of the diagnosis of vermian rotation. 3D median planes were obtained with both OMNIVIEW and tomographic ultrasound imaging.ResultsMeasurements of the cerebellar vermis were highly correlated between two‐dimensional and 3D median planes. The diameter of the cerebellar vermis follows growth approximately predicted by the quadratic regression equation. The normal vermis was almost parallel to the brain stem, with the average angle degree to be <2° in normal fetuses. The average angle degree of the 9 cases of vermian rotation was ﹥5°.ConclusionsThree‐dimensional median planes are obtained more easily than two‐dimensional ones, and allow accurate measurements of the cerebellar vermis. The 3D approach may enable rapid assessment of fetal cerebral anatomy in standard examination. Measurements of cerebellar vermis may provide a quantitative index for prenatal diagnosis of posterior fossa malformations. © 2012 John Wiley & Sons, Ltd.
Performance results from micro‐cell based high concentration photovoltaic research development and demonstration systems
Authors: Ghosal Kanchan , Burroughs Scott , Heuser Karsten , Setz Daniel , Garralaga‐Rojas Enrique 
Published: December 2012

ABSTRACTSemprius has a novel micro‐cell based approach that addresses the cost, performance and reliability requirements of high concentration photovoltaic systems. A design that has a geometric concentration ratio of >1100 suns and three‐junction 0.36 mm2 micro‐transfer printed cells is now complete. A module efficiency of 33.9% at a direct normal irradiance of 850 W/m2 and cell temperature of 25°C has been independently validated for this design by the Instituto de Energia Solar at the Universidad Politecnica de Madrid. This is the highest measured module efficiency for any PV module, designed for commercial use. Several research, development and demonstration (RD&D) systems have been installed with these modules to collect early on‐sun data and validate the technology. This paper presents module characterization and on‐sun system results from a 3.5‐kWp RD&D system installed at Instituto de Sistemas Fotovoltaicos de Concentracion, Puertollano, Spain by Semprius and Siemens. In addition, results from cleaning experiments and thermal performance of the system are presented from another RD&D system in Tucson. Comparisons of the performance of the Tucson RD&D system with co‐located one‐axis Si and fixed‐tilt Si systems are also presented. Copyright © 2012 John Wiley & Sons, Ltd.
Critical metals in strategic photovoltaic technologies: abundance versus recyclability
Authors: Anctil Annick , Fthenakis Vasilis 
Published: December 2012

ABSTRACTResearch efforts have been directed toward photovoltaic technologies using “abundant” base metals such as copper and zinc (e.g., CZTS or more recently CZTSSe) to overcome the material constraint challenges posed by tellurium, indium, germanium and gallium in current generation technologies (e.g., CdTe, CIGS, a‐Si/thin‐film Si). These materials are limited in supply because they are minor byproducts of copper, zinc, lead and aluminum production and their economic production is inherently linked to that of the base metals. On the other hand, although the base metals currently are abundant, their reserves are not inexhaustible. In addition to resource availability, the main sustainability metrics for large scales of photovoltaics growth are low cost and minimum environmental impact. As photovoltaics installations grow to greatly displace traditional power generation infrastructures, recycling will play an increasingly important role in managing their end‐of‐life and relieving pressure on the prices of critical materials. Identifying potential issues of current technologies can help implement take‐back or recycling program ahead of time. This work explores the material recycling potential of various commercial and under development photovoltaic technologies. It sheds light on a dimension of sustainability that has not been investigated before. On the basis of entropy analyses, documented by the experience of recycling electronic products, we show that recycling of some types of photovoltaic modules that are based on “abundant” materials could be burdened by complexity and lack of value, creating, therefore, concerns associated with both end‐of life environmental impacts and resource availability. Published 2012. This article is a U.S. Government work and is in the public domain in the USA.
Effect of resistive switching and electrically driven insulator–conductor transition in PbZrO3 single crystals
Authors: Jankowska‐Sumara Irena , Szot Krzysztof , Majchrowski Andrzej , Roleder Krystian 
Published: December 2012

AbstractIn this work, the results of detailed investigations of classical current–voltage characteristics measured both on the macro‐ and nanoscale with the use of LC‐AFM microscopy are presented. With decreasing frequencies abnormal hysteresis I(V) loops in a PbZrO3 single crystal were observed, showing a bipolar resistive switching behavior. The observed phenomena have been accounted for by the nonstoichiometry and defects produced electrochemically in the surface layers. Due to the nonstoichiometric composition of the crystal surface we showed the possibility of reversible transformation from an insulating to a conducting state in an antiferroelectric crystal by an electroforming process. The model of filamentary structure produced by extended defects and an electrochemical process is applied here to explain the data.
Augmented reality to the rescue of the minimally invasive surgeon. The usefulness of the interposition of stereoscopic images in the Da Vinci™ robotic console
Authors: Volonté Francesco , Buchs Nicolas C. , Pugin François , Spaltenstein Joël , Schiltz Boris , Jung Minoa , Hagen Monika , Ratib Osman , Morel Philippe 
Published: December 2012

AbstractBackgroundComputerized management of medical information and 3D imaging has become the norm in everyday medical practice. Surgeons exploit these emerging technologies and bring information previously confined to the radiology rooms into the operating theatre. The paper reports the authors’ experience with integrated stereoscopic 3D‐rendered images in the da Vinci surgeon console.MethodsVolume‐rendered images were obtained from a standard computed tomography dataset using the OsiriX DICOM workstation. A custom OsiriX plugin was created that permitted the 3D‐rendered images to be displayed in the da Vinci surgeon console and to appear stereoscopic.These rendered images were displayed in the robotic console using the TilePro multi‐input display. The upper part of the screen shows the real endoscopic surgical field and the bottom shows the stereoscopic 3D‐rendered images. These are controlled by a 3D joystick installed on the console, and are updated in real time.ResultsFive patients underwent a robotic augmented reality‐enhanced procedure.The surgeon was able to switch between the classical endoscopic view and a combined virtual view during the procedure. Subjectively, the addition of the rendered images was considered to be an undeniable help during the dissection phase.ConclusionWith the rapid evolution of robotics, computer‐aided surgery is receiving increasing interest. This paper details the authors’ experience with 3D‐rendered images projected inside the surgical console. The use of this intra‐operative mixed reality technology is considered very useful by the surgeon. It has been shown that the usefulness of this technique is a step toward computer‐aided surgery that will progress very quickly over the next few years. Copyright © 2012 John Wiley & Sons, Ltd.
Robust nonlinear stability and performance analysis of an F/A‐18 aircraft model using sum of squares programming
Authors: Anderson James , Papachristodoulou Antonis 
Published: December 2012

SUMMARYIn this paper, we develop algorithms for the computational analysis of stability and robust performance properties of nonlinear models governed by polynomial differential equations in quasi‐Linear Parameter Varying form subject to parametric uncertainty. The methods presented use the sum of squares decomposition and ideas from real algebraic geometry to represent polynomial non‐negativity over closed sets to compute various system properties such as gain, regions of attraction, reachable sets and nonlinear Hankel norm approximations. The methods we present are then illustrated on a nonlinear model of an F/A‐18 aircraft short‐period dynamics subject to uncertainty in the aerodynamic coefficients. Copyright © 2012 John Wiley & Sons, Ltd.
Stabilization of interconnected dynamical systems by online convex optimization
Authors: Hermans R.M. , Lazar M. , Jokić A. 
Published: December 2012

SUMMARYThe problem of stabilizing networks of interconnected dynamical systems (NDS) in a scalable fashion is considered. As the first contribution, a generalized lemma and example network are provided to demonstrate that state‐of‐the‐art, tractable dissipation‐based NDS stabilization methods can fail even for simple unconstrained, linear, and time‐invariant dynamics. Then, a solution to this issue is proposed, in which controller synthesis is decentralized via a set of parameterized storage functions. The corresponding stability conditions allow for max‐type construction of a trajectory‐specific Lyapunov function for the full closed‐loop network, whereas neither of the local storage functions is required to be monotonically converging. The provided approach is indicated to be nonconservative in the sense that it can generate converging closed‐loop trajectories for the motivating example network and a prescribed set of initial conditions. For input‐affine NDS and quadratic parameterized storage functions, the synthesis scheme can be formulated as a set of low‐complexity semidefinite programs that are solved online, in a receding horizon fashion. Moreover, for linear and time‐invariant networks, an even simpler, explicit control scheme is derived by interpolating a collection of a priori generated converging state and control trajectories in a distributed fashion. Copyright © 2012 John Wiley & Sons, Ltd.
Transmission planning for wind energy in the United States and Europe: status and prospects
Authors: Smith J. Charles , Osborn Dale , Zavadil Robert , Lasher Warren , Gómez‐Lázaro Emilio , Estanqueiro Ana , Trotscher Thomas , Tande John , Korpås Magnus , Van Hulle Frans , Holttinen Hannele , Orths Antje , Burke Daniel , O'Malley Mark , Dobschinski Jan , Rawn Barry , Gibescu Madeline , Dale Lewis 
Published: December 2012

AbstractThis paper provides an overview of major transmission planning activities related to wind integration studies in the United States and Europe. Transmission planning for energy resources is different from planning for capacity resources. Those differences are explained, and illustrated with examples from several regions of the United States and Europe. Transmission planning for wind is becoming an iterative process consisting of generation expansion planning, economic‐based transmission planning, system reliability analysis, and wind integration studies. A brief look at the policy environment in which this activity is taking place is provided. A set of coherent and collaborative transmission planning, siting, and permitting policies and cost allocation method must be developed to achieve the intended objectives. The scale of transmission development envisioned for this purpose will require unprecedented cooperation across multiple jurisdictional boundaries.This article is categorized under:

Wind Power > Systems and Infrastructure
Energy Infrastructure > Systems and Infrastructure
Energy Systems Economics > Systems and Infrastructure
Data mining in education
Authors: Romero Cristobal , Ventura Sebastian 
Published: December 2012

AbstractApplying data mining (DM) in education is an emerging interdisciplinary research field also known as educational data mining (EDM). It is concerned with developing methods for exploring the unique types of data that come from educational environments. Its goal is to better understand how students learn and identify the settings in which they learn to improve educational outcomes and to gain insights into and explain educational phenomena. Educational information systems can store a huge amount of potential data from multiple sources coming in different formats and at different granularity levels. Each particular educational problem has a specific objective with special characteristics that require a different treatment of the mining problem. The issues mean that traditional DM techniques cannot be applied directly to these types of data and problems. As a consequence, the knowledge discovery process has to be adapted and some specific DM techniques are needed. This paper introduces and reviews key milestones and the current state of affairs in the field of EDM, together with specific applications, tools, and future insights. © 2012 Wiley Periodicals, Inc.This article is categorized under:

Application Areas > Business and Industry
Syntheses, Structures and Properties of Lanthanide Organic Frameworks incorporating 1H‐benzimidazole‐2‐carboxylic Acid
Authors: Yang Yang , Qiao Cheng‐Fang , Wei Qing , Xia Zheng‐Qiang , Chen San‐Ping , Zhang Guo‐Chun , Zhou Chun‐Sheng , Gao Sheng‐Li 
Published: December 2012

AbstractA family of new lanthanide compounds [Ln(HBIC)3]n [Ln = Ce (1), Dy (2), Er (3); H2BIC = 1H‐benzimidazole‐2‐carboxylic acid] was obtained under hydrothermal conditions and characterized by elemental analysis, IR, X‐ray single crystal diffraction, thermal and luminescent analyses. X‐ray single crystal diffraction shows that compounds 1–3 are isotypic and exhibit 2D networks constructed by bridging‐chelating HBIC– linkers and lanthanide ion nodes, in which each central lanthanide atom is surrounded by five flexible HBIC– ligands with two kinds of new coordination modes, yielding a distorted two‐capped triangle prism arrangement. Moreover, the thermal and photoluminescence properties of 1–3 were also investigated.
B=N Bonds and BCN Rings – Reactivity and Charge Density Studies
Authors: Winkelhaus Daniel , Vishnevskiy Yuri V. , Berger Raphael J. F. , Stammler Hans‐Georg , Neumann Beate , Mitzel Norbert W. 
Published: December 2012

Abstract(F5C6)2BNMe2(1) was prepared and (F3C)2BNMe2(2) was resynthesized. The crystal structures of both compounds were determined. In contrast to2, compound1does not react with diazomethanes under carbine insertion into the BN bond. In this way the known (F3C)2BCH(SiMe3)NMe2(3) was resynthesized from2and its solid‐state structure was determined. The electron densities of compounds1,2, and3and those of the simpler model compound (F3C)2BCH2NMe2(4) as well as that of the BN/CC isoelectronic compound (F3C)2CCH2CMe2(5) for comparison were calculated and their topologies analysed in terms of the Quantum Theory of Atoms in Molecules (QTAIM). Despite2has a shorter B–N bond in calculations and in the crystal than1, the atomic charges and electron density parameters to QTAIM are very similar for both compounds and cannot explain the different reactivity. The three‐membered rings3and4do not show bond‐critical points for their B–N bonds. The nature of the B–N bond region was also analysed in terms of the source function contributions in QTAIM, which demonstrated the importance of the close proximity of a third atom in three‐membered rings for the charge density topologies in such systems.
Detection of human papillomavirus genotypes associated with mucopurulent cervicitis and cervical cancer in Changchun, China
Authors: Liu Wei , Wu En‐Qi , Yu Xiang‐Hui , Feng Li‐Hua , Jiang Chun‐Lai , Zha Xiao , Kong Wei 
Published: December 2012

AbstractObjectiveTo determine the prevalence and genotype distribution of human papillomavirus (HPV) infection among Chinese patients with mucopurulent cervicitis (MPC) or cervical cancer (CC).MethodsIn total, 191 cases of CC (n = 66), acute MPC (n = 84), and healthy cervix controls (n = 41) were initially included; samples were collected between May 21, 2008, and October 9, 2011. Cervical specimens were screened for HPV using a nested polymerase chain reaction assay and DNA sequencing.ResultsOverall prevalence of HPV infection was 20.0% in the control group, 53.3% in the MPC group, and 93.8% in the CC group. The predominant genotype detected in all 3 groups was the oncogenic variant HPV 16 (87.7%, 18.7%, and 10.0% in the CC, MPC and control specimens, respectively). The second most frequent genotype among patients with MPC was HPV 58. This variant is also oncogenic and was detected at a higher rate in the MPC group (9.3%) than in the control (2.5%) and CC (1.5%) groups.ConclusionInfection with HPV was prevalent among Chinese women with MPC or CC. Furthermore, the high prevalence of oncogenic genotypes observed among HPV‐positive patients with MPC suggests that this group is at increased risk of developing CC.