bluuebunny/crossref_metadata_2025_split huggingface dataset:
Machine learning analysis of serum cholesterol's impact on knee osteoarthritis progression
Authors: Li Hong-bo , Du Yong-jun , Kenmegne Guy Romeo , Kang Cheng-wei 
Published: August 2024

AbstractThe controversy surrounding whether serum total cholesterol is a risk factor for the graded progression of knee osteoarthritis (KOA) has prompted this study to develop an authentic prediction model using a machine learning (ML) algorithm. The objective was to investigate whether serum total cholesterol plays a significant role in the progression of KOA. This cross-sectional study utilized data from the public database DRYAD. LASSO regression was employed to identify risk factors associated with the graded progression of KOA. Additionally, six ML algorithms were utilized in conjunction with clinical features and relevant variables to construct a prediction model. The significance and ranking of variables were carefully analyzed. The variables incorporated in the model include JBS3, Diabetes, Hypertension, HDL, TC, BMI, SES, and AGE. Serum total cholesterol emerged as a significant risk factor for the graded progression of KOA in all six ML algorithms used for importance ranking. XGBoost algorithm was based on the combined best performance of the training and validation sets. The ML algorithm enables predictive modeling of risk factors for the progression of the KOA K–L classification and confirms that serum total cholesterol is an important risk factor for the progression of KOA.
Material engineering and application of hybrid biomimetic-de novo designed elastin-like polypeptides
Authors: Geng Zhuoran , Laakko Timo , Hokkanen Ari , Södergård Caj , Maasilta Ilari , Mohammadi Pezhman 
Published: August 2024

AbstractThe global concern over environmental consequences of petrochemical-derived plastics underscores the urgent need for sustainable and biodegradable polymers. In this context, elastin-like polypeptides emerge as a promising solution, offering multiple advantages, including remarkable mechanical properties, biocompatibility, customizable functionalities, and renewable sourcing through biosynthetic production in microbes, making them a compelling choice for various applications. We previously demonstrated accelerated engineering of a new class of elastin-like polypeptide‐based materials through hybrid biomimetic‐de novo predictive molecular design. The resulting variants exhibited enhanced molecular stability compared to their natural counterparts, catering to a range of technical applications that involve harsh downstream processing conditions. Here, we showcase the use of some of these previously discovered hybrid variants and illustrate the effective translation of the predicted molecular designs in structural and functional materials in several high-added-value applications. This includes multiscale drug-encapsulating vehicles with controlled release, multifunctional wound coverings, and all-aqueous-based biobased photoresists for creating 2D/3D microstructures.
Building machine learning prediction models for well-being using predictors from the exposome and genome in a population cohort
Authors: Pelt Dirk H. M. , Habets Philippe C. , Vinkers Christiaan H. , Ligthart Lannie , van Beijsterveldt Catharina E. M. , Pool René , Bartels Meike 
Published: August 2024

AbstractEffective personalized well-being interventions require the ability to predict who will thrive or not, and the understanding of underlying mechanisms. Here, using longitudinal data of a large population cohort (the Netherlands Twin Register, collected 1991–2022), we aim to build machine learning prediction models for adult well-being from the exposome and genome, and identify the most predictive factors (N between 702 and 5874). The specific exposome was captured by parent and self-reports of psychosocial factors from childhood to adulthood, the genome was described by polygenic scores, and the general exposome was captured by linkage of participants’ postal codes to objective, registry-based exposures. Not the genome (R2 = −0.007 [−0.026–0.010]), but the general exposome (R2 = 0.047 [0.015–0.076]) and especially the specific exposome (R2 = 0.702 [0.637–0.753]) were predictive of well-being in an independent test set. Adding the genome (P = 0.334) and general exposome (P = 0.695) independently or jointly (P = 0.029) beyond the specific exposome did not improve prediction. Risk/protective factors such as optimism, personality, social support and neighborhood housing characteristics were most predictive. Our findings highlight the importance of longitudinal monitoring and promises of different data modalities for well-being prediction.
Incorporating Parents' Lived Experiences Into the Pediatric Audiology Course: A Qualitative Analysis of Student Reflections
Authors: Alanazi Ahmad A. , Nicholson Nannette 
Published: August 2024

Purpose:
This study explores the underutilized pedagogical approach of incorporating lived experiences of parents with children possessing diverse hearing profiles and their family characteristics into the audiology curriculum for students. The aim was to investigate the impact of integrating such experiences into the classroom as an andragogical learning experience through the qualitative analysis of written student reflections.

Method:

Twelve (
N
= 12) third-year female audiology students enrolled in a pediatric auditory (re)habilitation course attended a parent panel presentation during their regularly scheduled face-to-face class. Five parents of children with diverse hearing differences and diverse technology, communication, and educational choices participated on the panel as guest speakers via the Zoom platform. Students completed written reflections based on Rolfe's reflective framework. Written reflections were downloaded from Canvas and de-identified prior to uploading to NVivo software for coding, utilizing an inductive grounded theory coding strategy coupled with content analysis.

Findings:
This study underscores the effectiveness of written reflections as an effective andragogical learning model. Through reflective practice, students gained a deeper understanding of their experiences, values, and learning journeys, enhancing their competency in pediatric audiology and auditory (re)habilitation. Students articulated previous knowledge and learning experiences, utilized newfound insights from exposure to the parent panel of shared lived experiences, and connected this knowledge with future clinical applications.

Conclusions:
Key findings underscore the effectiveness of reflective practice as an andragogical learning model, facilitating the integration of prior experiences with new knowledge. Moreover, it aids the transition of the professional journey from the familiar to the unfamiliar, demonstrating the impact of combining real-world lived experiences to reinforce and highlight classroom topics. Additionally, reflective practice enhances professional efficacy by valuing patient/parent perspectives regarding clinical care and aligning with evidence-based principles.
Enabling artificial intelligence‐based scenario application in new type power systems
Authors: Fan Shixiong , Guo Jianbo , Ma Shicong , Wang Guozheng , Li Dongqi , Zhao Zening 
Published: August 2024

AbstractAt present, artificial intelligence (AI) technology, as a disruptive and frontier technology, is changing people's production and lifestyle with the cross combination of other scientific fields. Under the background of Green and low‐carbon transition in energy, the construction of new type power systems (NTPS) is the future direction of the transformation and development of the power industry. AI is an important supporting technology for the digital transformation of the power industry, which can accelerate the construction of NTPS and new energy systems. This article provides the author's viewpoints on application of AI technologies in NTPS, mainly involving the development of electric power AI and the main problems it currently faced. The discussion on the bottlenecks of AI application will be focused on data and models. Some future research directions are also presented.
Artificial intelligence driving perception, cognition, decision‐making and deduction in energy systems: State‐of‐the‐art and potential directions
Authors: Dong ZhaoYang , Wang Tianjing 
Published: August 2024

AbstractIn the context of energy systems, managing the complex interplay between diverse power sources and dynamic demands is crucial. With a focus on smart grid technology, continuously innovating artificial intelligence (AI) algorithms, such as deep learning, reinforcement learning, and large language model technologies, have been or have the potential to be leveraged to predict energy consumption patterns, enhance grid operation, and manage distributed energy resources efficiently. These capabilities are essential to meet the requirements of perception, cognition, decision‐making, and deduction in energy systems. Nevertheless, there are some critical challenges in efficiency, interpretability, transferability, stability, economy, and robustness. To overcome these challenges, we propose critical potential directions in future research, including reasonable sample generation, training models with small datasets, enhancing transfer ability, combining with physics models, collective generative pre‐trained transformer‐agents, multiple foundation models, and improving system robustness, to make advancing AI technologies more suitable for practical engineering.
Transient stability of grid following inverters: The impacts of damping and fault ride‐through
Authors: Zhang Qi , Gu Yunjie , Liu Dong , Wang Chenxu , Yang Kehu , Chen Zhe 
Published: August 2024

AbstractThe interaction of grid following inverters with a weak grid raises risks of transient instability. The effects of damping and fault‐ride through (FRT) make the transient dynamics more complicated. To investigate the impact of FRT on the transient stability of converters, this paper first employs the switch system theory to construct a mathematical model for the synchronous mechanism of inverters. Secondly, the method of semi‐algebraic system real root classification is comprehensively used to analyse the existence of equilibrium points (EPs) and provide necessary and sufficient conditions for their existence. Finally, based on the theory of differential geometry, a method for computing the stability domain of converters is proposed. Compared with traditional methods, the results obtained from this approach are precise and non‐conservative. The study in this paper indicates that the equivalent damping effect from the proportional control in a phase‐locked loop significantly enlarges the stability region, whereas the active current injection shrinks the stability region. The reactive current droop characteristic also has impacts on the stability region, especially with active current injection. The switchover between the droop mode and constant current mode requires extra precaution in the calculation of the EPs and critical fault clearing time.
Thrombosehäufigkeit bei ambulanten Post-COVID-Patienten
Authors: Murena-Schmidt Laurenz , Murena-Schmidt Renate , Franzen Damian 
Published: August 2024

Zusammenfassung
Ziel der Studie Ziel dieser prospektiven Pilotstudie war es, im ambulanten Krankengut einer phlebologischen Schwerpunktpraxis zu ermitteln, ob im Intervall 2–4 Monate post-COVID mit einer erhöhten Inzidenz thromboembolischer Ereignisse zu rechnen ist.
Methodik Im Rahmen einer systematischen Nachuntersuchung von COVID-Folgeerkrankungen wurden 103 konsekutive Patienten zur Teilnahme an einer phlebologischen Untersuchung eingeschlossen. Diese umfasste nach einem standardisierten Untersuchungsprotokoll neben der Anamnese die Bestimmung der klinischen Wahrscheinlichkeit nach Wells, die komplette Kompressions- und Farbduplexsonografie und die laborchemische Bestimmung der D-Dimere.
Ergebnisse Insgesamt ließen sich 4 thrombotische Ereignisse nachweisen (3,9%). Davon betrafen 2 das tiefe (1,9%) und 2 das oberflächliche (1,9%) Beinvenensystem. In Bezug auf das durchschnittliche Patientengut der phlebologischen Schwerpunktpraxis (TVT-Häufigkeit von 1,48%) ergab sich jedoch keine signifikante TVT-Häufung in dem hier untersuchten Kollektiv (p=0,69).
Schlussfolgerung Die auffällige, aber insgesamt relativ niedrige Inzidenz von Thrombosen als Folge einer SARS-CoV-2-Infektion stützt die Annahme, dass Patienten mit erhöhtem Thromboserisikoprofil nicht nur in der Akutphase der COVID-Infektion, sondern auch noch nach 2–4 Monaten post-COVID einer vermehrten Aufmerksamkeit bedürfen.
Aneurysma spurium nach endovenöser Laserablation einer Rezidivvarikose der Vena saphena parva
Authors: Willenberg Torsten , Haine Axel , Ducommun Jean-Claude 
Published: August 2024

ZusammenfassungWir berichten über einen 70-jährigen Patienten, der aufgrund einer Rezidivvarikose der linken V. saphena parva einer endovenösen Laserablation mit 1470nm unterzogen wurde. Der Patient klagte bereits kurz nach der Behandlung über Schmerzen in der oberen Wadenregion. Die erste postinterventionelle Kontrolle 2 Tage später zeigte ein Aneurysma spurium am dorsalen Unterschenkel unterhalb der Fossa poplitea. Der Befund wurde zunächst mit einer Thrombininjektion versorgt, rezidivierte jedoch und musste schließlich mit einer intraarteriellen Coil-Embolisation behandelt werden. Diese Arbeit soll endovenöse Therapeuten auf eine sehr seltene Komplikation aufmerksam machen.
Use of peroral cholangiopancreatoscopy-assisted endoscopic mucosal resection for biliopancreatic intraductal lesions
Authors: Zhang Wengang , Zhai Yaqi , Shao Bozong , Wang Jiafeng , Wu Qingzhen , Chai Ningli , Linghu Enqiang 
Published: August 2024

Abstract
Background This study aimed to assess the feasibility and safety of performing cholangiopancreatoscopy-assisted endoscopic mucosal resection (CA-EMR) for biliopancreatic intraductal lesions.
Methods Special electrocautery snares and injection needles that can pass through the working channel of a single-operator cholangiopancreatoscope were developed. Between November 2023 and April 2024, we performed CA-EMR for two patients with gallbladder polyps, one patient with a neoplastic lesion in the common bile duct (CBD), and one patient with a neoplastic lesion in the main pancreatic duct. The technical success rate and adverse events were recorded.
Results All four CA-EMR procedures were performed successfully. Postoperative pathology revealed inflammatory gallbladder polyps in two patients, low grade intraepithelial neoplasia of the CBD in one patient, and intraductal papillary mucinous neoplasm (IPMN) in one patient. The patient with IPMN experienced mild postoperative pancreatitis and recovered after conservative treatment. No adverse events were encountered in the other three CA-EMR procedures.
Conclusion This study preliminarily confirmed the feasibility and safety of CA-EMR for treating biliopancreatic intraductal lesions.
Training in Public Health Informatics and Technology Leveraging a Multi-institutional Partnership Model and Emphasizing Experiential Learning
Authors: Rajamani Sripriya , Waterfield Kristie C. , Austin Robin , Singletary Vivian , Odowa Yasmin , Miles-Richardson Stephanie , Winters Tony , Powers Brenton , LaRoche Feather , Trachet Sarah , Fritz Jennifer , Leider Jonathon P. , Wurtz Rebecca , Shah Gulzar H. 
Published: August 2024

Abstract
Background and Objective Though public health is an information-intense profession, there is a paucity of workforce with Public Health Informatics and Technology (PHIT) skills, which was evident during the coronavirus disease 2019 (COVID-19) pandemic. This need is addressed through the PHIT workforce program (2021–2025) by the Office of the National Coordinator for training and to increase racial and ethnic diversity in the PHIT workforce. The objective is to share details on the Training in Informatics for Underrepresented Minorities in Public Health (TRIUMPH) consortium, funded by the PHIT workforce program.
Methods The TRIUMPH consortium is a collaboration between academic and practice partners with a commitment to training 879 students in PHIT. The Schools of Public Health and Nursing at the University of Minnesota, Jiann-Ping Hsu College of Public Health at Georgia Southern University, Morehouse School of Medicine, and Public Health Informatics Institute offer PHIT training through various programs. Academic institutions focus on student recruitment, developing courses/curriculum, and granting degrees/certificates, and the role of practice partners is to support experiential learning through internships/practicums.
Results The TRIUMPH consortium is progressing toward its goals, with 692 students (79%) already trained in a PHIT modality as of December 2023. The learners comprise diverse race/ethnicity, including White (48%), Black/African American (32%), Asian (10%), White Hispanic (5%), American Indian/Alaska Native (2%), and Black Hispanic (1%). Numerous internships have been completed in settings ranging from state/local public health agencies to health care delivery systems. Diversity initiatives were supported by partnering with existing programs (e.g., the AMIA First Look program and the Nursing Knowledge Big Data Science conference).
Conclusion This consortium model is an excellent approach to informatics training and sharing expertise across partners. It provides scalability and broader geographic outreach while presenting opportunities to students from underrepresented backgrounds. Lessons learned have implications for overall informatics training (e.g., partnerships models, promoting racial/ethnic diversity).
Spectrum of Somatic Malignancy in Testicular Germ Cell Tumors—A Histopathological Review of 25 Cases with Clinical Outcome
Authors: Subramanian Priyadarsani , Arora Amandeep , Pal Mahendra , Prakash Gagan , Maitre Priyamvada , Murthy Vedang , Joshi Amit , Rane Swapnil , Desai Sangeeta , Menon Santosh 
Published: August 2024

Abstract
Introduction Germ cell tumors (GCTs) are the commonest testicular malignancy in young males. These tumors are highly chemoresponsive, however become resistant to conventional therapy when a somatic-type malignancy (SM) develops, which happens in ∼3 to 6% of the cases.
Methods We reviewed the histologic profile of all cases of testicular/retroperitoneal GCT with SM, diagnosed over a period of 12 years in our institute. Correlation of histologic profile with clinical outcome was done wherever feasible.
Results A total of 25 cases of testicular/retroperitoneal GCT with SM were identified for review. The histological spectrum of SMs included carcinoma (n = 9), sarcoma (n = 9), embryonic-type neuroectodermal tumor (ENET) (n = 4), and other rare histological types (n = 3). SMs were frequently seen at the resected metastatic sites (n = 13) and in postchemotherapy setting (n = 12); 14 cases had concurrent GCT and SM at the time of diagnosis/initial resection and 9 cases presented as late relapses (more than 2 years after initial presentation). Four patients were treated with metastasectomy and lymph node dissection, six patients were treated with combined resection and chemotherapy, and nine patients were treated with only adjuvant chemotherapy. The patients with SM confined to testis and those treated with multimodality approach had relatively better outcome.
Conclusion GCTs with SM are a highly heterogeneous group of tumors with varying histologic types and management strategies. Strict adherence to histological diagnostic criteria, differentiating these tumors from close mimics such as glandular and sarcomatoid yolk sac tumors, teratomatous overgrowth, and a new second primary somatic tumor are important due to implications in management and prognosis.
Imaging in Neurotuberculosis
Authors: Agarwal Sushant , Charan Bheru Dan , Shah Shariq Ahmad , Singh Ekamjot , Garg Ajay 
Published: August 2024

AbstractCentral nervous system tuberculosis can occur in various forms and carries high morbidity despite anti-tubercular treatment. Accurate and early diagnosis based on imaging can help improve prognosis and prevent complications. Confirmation of tubercular bacteria in CSF culture methods, and molecular analysis poses challenges due to invasive and time-consuming procedures. Advanced neuroimaging techniques are greatly helpful in making presumptive diagnoses. Here we described imaging features of multiple forms of CNS tuberculosis with advanced neuroimaging. This paper will help neuroradiologists to identify CNS TB and related imaging features.
Multiphasic Computed Tomography Enhancement Characteristics and Utility of Delayed Phase in Infiltrative Hepatocellular Carcinoma
Authors: Singh Tarvinder , Mehta Nandita , Gupta Pankaj , Gulati Ajay , Gulati Mudita , Kalra Naveen , Premkumar Madhumita , Taneja Sunil , Jearth Vaneet , Sharma Vishal , Duseja Ajay 
Published: August 2024

Abstract
Objective The aims of this study are to compare the multiphasic contrast-enhanced computed tomography (CECT) characteristics of infiltrative hepatocellular carcinoma (HCC) with nodular HCC and to assess the conspicuity of infiltrative HCC on different phases of CECT.
Materials and Methods This retrospective study comprised consecutive treatment-naive cirrhotic patients diagnosed with infiltrative and nodular HCC between January 2020 and December 2021 based on a multiphasic CECT (comprising arterial, portal venous, and delayed phases). The diagnosis of HCC was based on the Liver Imaging Reporting and Data System (LI-RADS) v2018 criteria (LR-4 and LR-5 lesions). Infiltrative HCCs are characterized by large, irregular, permeative lesions spread over multiple liver segments or lobes. Nodular HCCs comprise well-defined tumor nodules. Two radiologists independently reviewed all CT images. Additionally, lesion conspicuity on the arterial, portal venous, and delayed phases was assessed.
Results One hundred fifty-eight patients (117 nodular and 41 infiltrative HCCs; mean age: 55.6 ± 17.2 years; 90 [56.9%] males) were included. Arterial phase hyperenhancement, portal venous/delayed phase washout, and delayed phase enhancing capsule were significantly associated with nodular HCCs (p = 0.002, 0.0001, and <0.0001, respectively). Portal vein, hepatic vein thrombosis, biliary dilatation, and ascites were significantly associated with infiltrative HCCs (p < 0.0001, 0.004, <0.0001, and 0.003, respectively). The interobserver agreement for the conspicuity of infiltrative HCC was the highest for the delayed phase (weighted kappa = 0.611).
Conclusion Infiltrative HCCs show the major LI-RADS features less frequently compared with nodular HCCs, and venous thrombosis is an important clue to the diagnosis. The delayed phase of multiphasic CECT is critical to identifying these lesions.
Whiteness at the abyss: reflections on a scene of attack
Authors: Hook Derek 
Published: August 2024

Abstract
This paper focusses on a series of online attacks that the author was subjected to after comments he had made in a closed lecture on the topic of ‘white anxiety’ were cut from the zoom recording and distributed widely online with the clear intent of causing outrage. The analysis of the material, which combines thematic, discourse analytic and personal reflections, yielded a series of core themes: 1) the role of the messages in consolidating an identity, 2) performative offensiveness, 3) perverse intimidations, 4) accusations/denials/expressions of racism, 5) the race-traitor as ideological dilemma, 6) antisemitism and 7) aggressive cordiality. The paper closes with a few reflections on the author’s enunciative position in respect of the attacks.