bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy Assessment of Satellite-Derived Bathymetry From Band Ratio Algoritm Around an Earth Dam
Authors: Abubakar Ahmadu Ali , T. Youngu T. 
Published: July 2024

Abstract

Long-term changes in the bathymetry of a reservoir using satellite-derived bathymetry (SDB) from Landsat 8 Operational Land Imager (OLI) imagery was investigated. The reservoir's initial design in 1973 included a specified spatial extent of 570,000 square meters, a maximum depth of 8.5 meters, and a water storage capacity of 2,600,000 cubic meters. However, sedimentation over time gradually reduced the storage capacity and depth, leading to a dredging operation in 2014 to restore some of its original features. Focusing on the post-dredging period, the study compares the results to the reservoir's initial design plan. Results indicate a consistent marginal decline in the spatial extent, with an overall decrease of 26.10% from impoundment to the present. Satellite-derived depths showed a clear downward trend, representing a significant reduction of 68.11% over half a century. The volume capacity exhibited a consistent decline, with an overall loss of 71.98% from impoundment to the present. The findings highlight the continuous challenges posed by sedimentation, underscoring the need for ongoing monitoring and effective management strategies to maintain the reservoir's functionality and capacity as a crucial water resource. Furthermore, the study establishes a strong positive correlation (R2 = 0.99) between storage volume capacity and derived depth values. This correlation validates the reliability and accuracy of the depth estimation method used, offering potential utility for reservoir management and water resource planning. Overall, the research emphasizes the importance of SDB for monitoring long-term changes in bathymetry and highlights the significance of effective sedimentation management to ensure sustainable reservoir utilization.
Suitability evaluation of an equivalent porous medium method for characterizing 2-D flow based on the fracture fractal dimension
Authors: Han Di , Ma Lei , Gao Di , Luo Qiankun , Fang Yunhai , Qian Jiazhong 
Published: July 2024

ABSTRACT
An equivalent porous medium (EPM) method is widely utilized in various practical applications of hydrogeological engineering with areas of a fractured geological medium (FGM). However, the suitability of the EPM model still lacks sufficient scientific evaluation when considering the distribution of water head and flow velocity. In this study, the suitability of the EPM model to the fractal dimension of a discrete fracture network (DFN) is analyzed based on numerical simulation experiments. The simulation results of the EPM model are compared with those of the DFN model. Then, a formula is proposed to evaluate the suitability of the EPM model for characterizing two-dimensional flow distribution. The results show that with the increase of the fractal dimension, the suitability of the EPM model decreases first and then increases, and the inflection point gradually appears in advance with the increase of the length–width ratio of the simulation domain. The length–width ratio of the simulation domain has a linear relationship with the suitability of the EPM model, and the slope increases with the increase of the fractal dimension. Finally, a quantitative evaluation method is proposed to calculate the suitability of the EPM model based on the fractal dimension and the length–width ratio of the simulation domain.
Optimization of Hypercholesterolemia Treatment after Heart Transplant: The Role of PCSK9 Inhibitors
Authors: Jesus Valero-Masa Maria , Ortiz-Bautista Carlos David , Castrodeza Javier , Martinez-Selles Manuel 
Published: July 2024

Background:
Previous studies have reported the benefit of statins after Heart Transplant (HT). However,
the use of high-dose statins might be limited in some HT patients due to intolerance and interactions with
immunosuppression or might not be enough to achieve Low-Density Lipoprotein (LDL) cholesterol goals. Hyperlipidemia
has been associated with coronary allograft vasculopathy. Proprotein convertase subtilisin/kexin
type 9 (PCSK9) inhibitors might be a safe and effective option in HT patients with suboptimal lipid control.

Methods:
In a retrospective study, we identified HT patients in our center with LDL cholesterol >100 mg/dL,
after diet modifications and up-titration of statins to maximum tolerated dose, treated with PCSK9i. The primary
endpoint was LDL reduction one month after, and secondary endpoints were the development of donorspecific
HLA antibodies (DSA) and the presence of coronary allograft vasculopathy or rejection.

Results:
From January, 2018, to January, 2024, we identified five HT patients treated with PCSK9 inhibitors.
In all cases, evolocumab was used. A significant reduction in LDL cholesterol was observed (151.6 ± 13.5
mg/dl to 72.4 ± 14.6 mg/dl; p = 0.04, mean reduction 75.7 ± 14.1 mg/dl), as well as in total cholesterol (231 ±
34.6 mg/dl to 152.2 ± 38.9 mg/dl; p < 0.01, mean reduction 78.8 ± 22.2 mg/dl). A significant increase in HDL
cholesterol was not observed (45.4 ± 10.9 mg/dl to 46.2 ± 11.1 mg/dl; p = 0.60). One patient developed DSA
five years after treatment onset. Rejection and coronary allograft vasculopathy were not observed.

Conclusion:
PCSK9 inhibitors are safe and effective in reducing LDL in HT patients. However, larger studies
are needed to clarify if they can reduce the development of coronary allograft vasculopathy.
Synthesis and Characterization of Pyridine-pyrrole-modified Carbon Nanotube Derivatives via Ylides
Authors: Çalışır Ümit 
Published: July 2024

:
The high dipolarophile structure of MWCNT compounds enables them to be used as a
reactive 2π member in 1,3-dipolar cycloaddition reactions. N-substituted glycine ester compounds
and employed 1,3-dipolar cycloaddition reactions involving azomethine-ylides for the synthesis
of multiwalled carbon nanotube compounds that underwent covalent modification. Initially, Nsubstituted
glycine esters (3a) and N-substituted glycine compounds were synthesized. Nsubstituted
glycine (4a) and substituted aromatic aldehyde derivatives were reacted with the dipolarophilic
MWCNTs, which have regioselectivity only on (6,6)-bonds, via azomethine ylide intermediates
over a 1,3-dipolar cycloaddition reaction to obtain the target pyridine-pyrrolemodified
carbon nanotube derivatives (6a-g). The compounds' structural characterizations were
achieved using FTIR, Raman, NMR, TEM, UV-VIS, and TGA methods. The dispersibility of the
compounds was evaluated in various solvents. The activity of each compound's antimicrobial properties against
Escherichia coli was assessed. Based on the obtained results, it was concluded that the compounds, by the
method employed, adsorbed Escherichia coli bacteria and decreased the bacterial concentration in their film
form. According to the results, the compounds can be used in bacterial adsorption-based purification systems
(the eradication of water and environmental pollutants) based on the results obtained.
Cesium Carbonate (Cs2CO3) in Organic Synthesis: A Sexennial Update (2018 to Date)
Authors: Varala Ravi , Achari Kamsali Murali Mohan , Hussein Mohammed , Alam Mohammed Mujahid , Ramanaiah Seella 
Published: July 2024

:
Cesium carbonate is an alkali carbonate salt that has numerous applications and has
been proven to be a mild inorganic base in organic synthesis. It has garnered significant attention
due to its practicality in C-H functionalization and heteroatom-heteroatom bond formation reactions,
in addition to its application in conventional synthetic transformations. In this six-year update,
we have examined the most important applications of Cs2CO3 in organic synthesis from
2018 to the present, including the scope of the reaction and providing detailed explanations of
the underlying mechanisms.
A Complete Sojourn of Monoclonal Antibodies: AI, Rare Diseases / Disorders and Immunotoxic Effects
Authors: Garg Sonakshi , Garg Gurisha , Patel Preeti , Gupta Ghanshyam Das , Kurmi Balak Das 
Published: July 2024

:
Monoclonal antibodies (mAbs) are magic bullets proved to be a wonder in the pharmaceutical
as well as medical fields. These are produced by various methods like hybridoma technology,
phage display technology, YAC technology, and transgenic animals and plants. Based on the
percentage of animal origin, mAbs are divided into chimeric, murine, humanized, and fully human.
This review covers the history and methods of mAb production, immunotoxicity (Immunosuppression,
immunostimulant, autoimmunity, hypersensitivity) associated with mAbs, and targets
of mAbs. It also compiles mAb production using AI, new modifications, and novel mAbs,
with its various clinical trial information ensuring the use of mAbs in rare diseases and disorders.
The Evaluation of the Impact of Antibiotic De-escalation among Paediatric Patients Admitted to Tertiary Care Hospital in Ajman, UAE: A Cross-sectional Retrospective Observational Study
Authors: Elshaeir Nour , Gillani Syed Wasif 
Published: July 2024

Background:
Antibiotic de-escalation therapy plays a vital role in reducing the risk of
bacterial resistance across the globe. This study elucidates the significance, determinants, and outcomes
pertaining to Antibiotic De-escalation (ADE). The ADE is acknowledged as a crucial component
within Antimicrobial Stewardship Programs (ASPs). The proliferation of antimicrobial-resistant
bacteria arises as an anticipated outcome of the extensive utilization of antibiotics, heightening
researchers' apprehensions regarding this global challenge.

Objective:
The primary objective of the study was to evaluate the usage of antibiotics in terms of
clinical outcomes (re-admission within 30 days and therapy outcomes upon discharge), adverse
events, duration of de-escalation, and duration of hospitalizations among pediatric patients admitted
to a tertiary care hospital due to various infectious diseases.

Methods:
A retrospective study was conducted during a four-month period, from January 2022 to
April 2023, at a tertiary care facility in Ajman, United Arab Emirates. Participants included in this
study were based on specific inclusion and exclusion criteria.

Results:
A total of 200 pediatric records were screened. The majority of participants, accounting
for 66.0%, were female, and 54.0% were classified as Arabs in terms of race. The mean age was
7.5 years (± 2.8). The most prevalent symptoms reported were fever (98%), cough (75%), and
sore throat (73%). Male participants were more inclined to present with bacterial infections
(88.2%) compared to viral infections (3.8%), bacterial and viral co-illnesses (2.5%), or parasitic infections
(1.3%) at the time of admission. Regarding clinical outcomes, 27% of patients were readmitted
with the same infection type, while 52% did not experience readmission. The analysis also
included information on the number of patients within each antibiotic therapy duration category,
alongside the mean duration of antibiotic de-escalation in hours with standard deviation (± SD).
The statistical significance of these associations was assessed using P-values, revealing a significant
relationship (P < 0.0001) between the duration of antibiotic therapy and the time required for
antibiotic de-escalation.

Conclusion:
The study's analysis revealed that individuals readmitted to the hospital, irrespective
of whether they presented with the same or a different infection type, exhibited prolonged durations
of antibiotic de-escalation. This observation underscores the potential influence of the patient's
clinical trajectory and the necessity for adjunctive therapeutic interventions on the duration of
antibiotic de-escalation.
Targeting Adenylate Cyclase: A Novel Concept for Stimulation of Neurogenesis and Pharmacotherapy of Alzheimer's Disease
Authors: Zyuz'kov Gleb Nikolaevich , Miroshnichenko Larisa Arkad`evna , Polykova Tatyana Yur`evna , Simanina Elena Vladislavovna , Chayikovskyi Alexander Vasil`evich 
Published: July 2024

Background:
The low effectiveness of existing pharmacotherapy strategies for Alzheimer's
disease (AD) makes it necessary to develop a new concept for the treatment of this type of
dementia. This search is promising to be carried out within the framework of the paradigm of targeting
intracellular signaling pathways in Regenerative-Competent Cells (RCCs).

Objective:
The purpose of the research is to study the impact of adenylate cyclase (AC) inhibitor
on disorders of the psychoemotional status in aged male C57BL/6 mice, as well as on the dynamics
of the content and functioning of RCCs nervous tissue.

Methods:
We examined the effect of the AC inhibitor (2ʹ,5ʹ-Dideoxyadenosine) on conditioned reflex
activity, behavioral and emotional profile in a mouse AD model (16-month-old (aged) male
C57BL/6 mice), as well as the functioning of neural stem cells (NSCs), neuronal-committed progenitors
(NCPs), and neuroglial cells in the subventricular zone of the cerebral hemispheres (SVZ).

Results:
In aged C57BL/6 mice, we found impairments in exploratory behavior, emotional reactivity,
and memory, which are the characteristics of senile dementia. Therapy based on AC inhibition
led to an increase in the number of NSCs and NPCs in the SVZ due to an increase in their proliferative
activity. These changes were more pronounced in NCPs. At the same time, a decrease in
the specialization intensity was recorded in NSCs. These phenomena developed against the background
of increased secretion of neurotrophic growth factors by oligodendrocytes and microglial
cells. The neuroregenerative effects of 2ʹ,5ʹ-dideoxyadenosine correlated with the correction of
age-related disorders of the psychoemotional status in aged mice.

Conclusion:
The results provide the basis for the development of targeted drugs based on AC inhibitors
to stimulate neurogenesis as an approach for the effective treatment of AD.
Provision representation by third parties
Authors: Tishkevich A. A. 
Published: July 2024

Relevance. The study is devoted to determining the substance of representation given by a third party and their place among the general models of third party participation in another contractual obligation (Articles 312, 313 and 430 of the Civil Code of the Russian Federation). The possibilities of applying the current rules of positive law on the participation of a third party in another contractual obligation to representation provided by a third party are analyzed. Due to the presence of only explanations of the Supreme Court of the Russian Federation on such representations, there is a need for scientific formulization in this regard.The purpose of the article is to formulization theoretical provisions on representation provided by a third party and their relationship to existing models of third party participation in another contractual obligation.Objectives. to determine the most appropriate rules for applying to representationы given by a third party on a specific model of a third party's participation in another contractual obligation.Methodology. The author used dialectical-materialistic method, methods of analysis and synthesis, a systematic method, as well as methods of description and formal-legal method.Results. Based on the results of the study, it was found acceptable to apply the rules on contract in favor of a third party (Article 430 of the Civil Code of the Russian Federation) to the construction of representation provided by a third party.Conclusion. The structure of representation given by a third party proposed by the Supreme Court of the Russian Federation should be properly integrated into the existing domestic system of contract law. However, it has been revealed that the legal substance of the representation provided by a third party is not acceptable for all general models of third party participation in another contractual obligation. The closest model of a third party's participation in another contractual obligation to the construction of representation provided by a third party should be considered a contract in favor of a third party.
Correction: Global Implications From the Rise and Recession of Telehealth in Aotearoa New Zealand Mental Health Services During the COVID-19 Pandemic: Mixed Methods Study (Preprint)
Authors: Werkmeister Benjamin , Haase Anne M , Fleming Theresa , Officer Tara N 
Published: July 2024

UNSTRUCTURED

Correction: Global Implications From the Rise and Recession of Telehealth in Aotearoa New Zealand Mental Health Services During the COVID-19 Pandemic: Mixed Methods Study

In “Global Implications From the Rise and Recession of Telehealth in Aotearoa New Zealand Mental Health Services During the COVID-19 Pandemic: Mixed Methods Study” ([JMIR Form Res 2023;7: e50486]) the authors noted an error with a date.

The error occurred in the following places.
1.	Abstract – Methods. “In total, 4,117,035 observations were analyzed between October 1, 2019, and August 1, 2022.”
This should read:
“In total, 4,117,035 observations were analyzed between September 2, 2019, and August 1, 2022.”
2.	Activity data – Overview. “This data set represented population-level data and included all clinical activities (4,117,035 observations) undertaken by outpatient mental health clinicians in the study regions between October 2019 and August 2022 to allow comparison of telehealth use between prelockdown, lockdown, and postlockdown periods.”
This should read:
“This data set represented population-level data and included all clinical activities (4,117,035 observations) undertaken by outpatient mental health clinicians in the study regions between September 2019 and August 2022 to allow comparison of telehealth use between prelockdown, lockdown, and postlockdown periods.”
3.	Table 1 – column 2, row 2. “October 1, 2019 (12 AM)”
This should read:
“September 2, 2019 (12 AM)”

The correction will appear in the online version of the paper on the JMIR Publications website together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories.
Pengaruh Kualitas Pelayanan Terhadap Kepuasan Konsumen
Authors: Mulia I Made Prabudi , Semara I Made Trisna 
Published: July 2024

Minum kopi bagi kaum muda dilihat sebagai gaya hidup dan sarana untuk mengekspresikan eksistensi mereka. Salah satu faktor yang menciptakan baik atau buruknya kepuasan pelanggan adalah kualitas pelayanan para bartender. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh kualitas pelayanan terhadap kepuasan pelanggan di Missibu Coffee Roaster & Showroom. Desain penelitian menggunakan desain kausal kuantitatif. Pengumpulan data penelitian dengan metode angket, wawancara dan observasi. Sumber data penelitian ini adalah data primer berupa hasil kuesioner. Populasi, seluruh pengunjung Missibu Coffee Roaster & Showroom, dengan teknik random sampling. Analisis data dalam penelitian ini menggunakan analisis regresi sederhana, uji t dan uji F. Kualitas pelayanan memiliki koefisien regresi 0,295 dan nilai sig 0,000<0,05. Pengaruh variabel kualitas pelayanan terhadap kepuasan pelanggan dari hasil pengujian koefisien determinasi menunjukkan koefisien korelasi (R) sebesar 0,576, variabel terikat memiliki nilai R mendekati 1, nilai Y. nilai R2 adalah 0,332 atau 33,2%, indikator ketidakpuasan pelanggan memiliki nilai mean minimum sebesar 3,22%. Berdasarkan hasil analisis data dan pembahasan di Missibu Coffee Roaster & Showroom dapat disimpulkan bahwa semakin tinggi kualitas pelayanan maka semakin tinggi pula kepuasan pelanggan. dan bisnis harus mampu mengisi kekosongan.

Drinking coffee is now not only identical to activities carried out by the elderly, young people also make coffee drinking activities a lifestyle and as a means of showing their existence. One of the factors that make good and bad customer satisfaction is the quality of barista service. The purpose of this study was to determine the quality of service affects customer satisfaction at Missibu Coffee Roaster & Showroom. The research design uses a causal quantitative design. Research data collection using questionnaire methods, interviews and observation methods. The data source in this study is primary data in the form of questionnaire results. Population, all visitors who visit Missibu Coffee Roaster & Showroom, with accidental sampling technique. Data analysis in this study used simple regression analysis tests, t-tests and F-tests. Service quality with a regression coefficient of 0.295 and a sig value of 0.000 <0.05. The magnitude of the influence of service quality variables on customer satisfaction from the results of the Coefficient of Determination test that the correlation coefficient (R) is 0.576, the dependent variable R value is close to 1, the Y value. R2 value of 0.332 which means 33.2%, the customer dissatisfaction indicator has the smallest average value of 3.22%. Based on the results of data analysis and discussion at Missibu Coffee Roaster & Showroom, it can be concluded that the higher the service quality, the higher the customer satisfaction, the perceived service quality has a strong influence on customer satisfaction at Missibu Coffee Showroom & Roaster, and the company must be able to improve its deficiencies.
A Risky Proposition: Setting Objectives and Assessing Business Environment Risks Using the Enterprise Risk Management Framework
Authors: Tribou Kimberly J. , Roberson Melinda , Roberson Mandy 
Published: July 2024

ABSTRACT
In the first part of this case, students are introduced to the five components of the 2017 COSO enterprise risk management (ERM) Framework and will use this framework to recommend objectives related to a small coffee shop’s strategic position and identify the associated risks. In the second part of the case, students will use Social, Technological, Economic, Environmental, Political, Legal, and Ethical (STEEPLE) Analysis to identify business environment risks and assess these risks regarding a new business opportunity. At the conclusion of the case, students should be able to recommend risk-conscious business objectives and performance targets that align with a business’s strategy as well as assess the risk associated with a new business opportunity. The topics addressed in this teaching case are appropriate for undergraduate and graduate-level managerial accounting, Accounting Information Systems (AIS), and Auditing courses where business environment risks are discussed and evaluated.
Data Availability: Data are available upon request.
JEL Classifications: M140; M410.