bluuebunny/crossref_metadata_2025_split huggingface dataset:
Early experience with laparoscopic lavage for perforated diverticulitis
Authors: Swank H A , Mulder I M , Hoofwijk A G M , Nienhuijs S W , Lange J F , Bemelman W A 
Published: February 2013

Abstract

Background
Laparoscopic lavage has recently emerged as a promising alternative to sigmoid resection in the treatment of perforated diverticulitis. This study examined an early experience with this technique.

Methods
The files of all patients with complicated diverticulitis were searched in 34 teaching hospitals of the Netherlands. Patients with perforated diverticulitis treated with laparoscopic lavage between 1 January 2008 and 31 December 2010 were included.

Results
Treatment with laparoscopic lavage was performed in only 38 patients in ten hospitals. Lavage was successful in controlling sepsis in 31 of the 38 included patients, with 32 per cent morbidity (10 of 31 patients) and fast recovery. Overall, 17 of 38 patients developed complications, of whom two had a missed overt sigmoid perforation. Two patients died from multiple organ failure and one from aspiration pneumonia; one other patient died after palliative management of inoperable lung carcinoma. Three patients in whom lavage was successful underwent subsequent sigmoid resection for recurrent diverticulitis. Patients in whom lavage was unsuccessful tended to have more co-morbidities, a higher preoperative C-reactive protein concentration and a higher Mannheim Peritonitis Index.

Conclusion
Laparoscopic lavage for perforated diverticulitis was feasible in the majority of patients, but identification of an overt sigmoid perforation and patient selection are of critical importance. © 2013 British Journal of Surgery Society Ltd. Published by John Wiley & Sons, Ltd.
Direct Nucleophilic Substitution of Free Allylic Alcohols in Water Catalyzed by FeCl3⋅6 H2O: Which is the Real Catalyst?
Authors: Trillo Paz , Baeza Alejandro , Nájera Carmen 
Published: February 2013

AbstractThe allylic substitution reaction, and particularly the direct allylic amination reaction, of free allylic alcohols in water catalyzed by FeCl3⋅6 H2O is described. This novel environmentally‐friendly methodology allows the use of a wide variety of nitrogenated nucleophiles such as sulfonamides, carbamates, benzamides, anilines, benzotriazoles, and azides, generally giving good yields of the corresponding substitution products. The synthetic applicability of the process is also demonstrated because the reaction can be performed on gram‐scale. Additionally, carbon nucleophiles such as silylated nucleophiles, aromatic compounds, and malonates also proved to be suitable for this transformation. Finally, the nature of the catalytic species present in aqueous media is unveiled, pointing towards the formation of hexaaquo iron(III) complexes.
The homo‐PADAM Protocol: Stereoselective and Operationally Simple Synthesis of α‐Oxo‐ or α‐Hydroxy‐γ‐acylaminoamides and Chromanes
Authors: Morana Fabio , Basso Andrea , Riva Renata , Rocca Valeria , Banfi Luca 
Published: February 2013

AbstractA straightforward and fully stereoselective synthesis of a new class of peptidomimetics, that is α‐oxo‐γ‐acylaminoamides, was achieved starting from various benzaldehydes by a sequence of 1) an asymmetric organocatalytic Mannich reaction, 2) a Passerini multicomponent reaction, 3) an amine deprotection–acyl migration protocol, and 4) a final oxidation. The whole sequence can be performed without purification of the intermediates and represents the first example of a homo‐Passerini–amine deprotection–acyl migration (PADAM) strategy. Highly stereoselective reduction of the α‐oxo‐γ‐acylaminoamides afforded α‐hydroxy‐γ‐acylaminoamides as well. In some cases both diastereomers were obtained by simply changing the reducing agent. Finally, starting from protected salicylaldehyde, the same sequence, followed by a Mitsunobu cyclization, afforded highly substituted chromanes.
Prevention of Recurrent Pericarditis With Colchicine in 2012
Authors: Markel Gal , Imazio Massimo , Brucato Antonio , Adler Yehuda 
Published: February 2013

AbstractThe most troublesome complication of acute pericarditis is recurrent pericardial inflammation, which occurs in 15%–32% of cases. The optimal method for prevention has not been fully established; accepted modalities include nonsteroidal anti‐inflammatory drugs, corticosteroids, immunosuppressive agents, and pericardiectomy. Over the last years, objective clinical evidence has matured and clearly indicates the important role and beneficial clinical effect of colchicine therapy in preventing recurrent pericarditis caused by various etiologies. Colchicine‐treated patients consistently display significantly fewer recurrences and longer symptom‐free periods, and even when attacks occur, they are weaker and shorter in nature. Notably, pretreatment with corticosteroids substantially attenuates the efficacy of colchicine, causing significantly more recurrences and longer therapy periods. The safety profile seems superior to other drugs, such as corticosteroids and immunosuppressive drugs. Colchicine is a safe and effective modality for the treatment and prevention of recurrent pericarditis, especially as an adjunct to other modalities, because it provides a sustained benefit, superior to all current modalities.The authors have no funding, financial relationships, or conflicts of interest to disclose.
Optimization of Marine Triterpene Sipholenols as Inhibitors of Breast Cancer Migration and Invasion
Authors: Foudah Ahmed I. , Jain Sandeep , Busnena Belnaser A. , El Sayed Khalid A. 
Published: February 2013

AbstractSipholenol A, a sipholane triterpene isolated from the Red Sea sponge Callyspongia siphonella, has the ability to reverse multidrug resistance in cancer cells that overexpress P‐glycoprotein (P‐gp). Here, the antimigratory activity of sipholenol A and analogues are reported against the highly metastatic human breast cancer cell line MDA‐MB‐231 in a wound‐healing assay. Sipholenol A and sipholenone A were semisynthetically optimized using ligand‐based strategies to generate structurally diverse analogues in an attempt to maximize their antimigratory activity. A total of 22 semisynthetic ester, ether, oxime, and carbamate analogues were generated and identified by extensive one‐ and two‐dimensional NMR spectroscopy and high‐resolution mass spectrometry analyses. Sipholenol A 4β‐4‐chlorobenzoate and 19,20‐anhydrosipholenol A 4β‐4‐chlorobenzoate esters were the most potent of all tested analogues in the wound‐healing assay, with IC50 values of 5.3 and 5.9 μM, respectively. Generally, ester derivatives showed better antimigratory activities than the carbamate analogues. A KINOMEscan of 19,20‐anhydrosipholenol A 4β‐benzoate ester against 451 human protein kinases identified protein tyrosine kinase 6 (PTK6) as a potential target. In breast tumor cells, PTK6 promotes growth factor signaling and migration, and as such the semisynthetic sipholanes were evaluated for their ability to inhibit PTK6 phosphorylation in vitro. The two analogues with the highest antimigratory activities, sipholenol A 4β‐4‐chlorobenzoate and 19,20‐anhydrosipholenol A 4β‐4‐chlorobenzoate esters, also exhibited the most potent inhibition of PTK6 phosphorylation inhibition. None of the compounds exhibited cytotoxicity in a normal epithelial breast cell line. These derivatives were evaluated in an in vitro invasion assay, where sipholenol A succinate potently inhibited MDA‐MB‐231 cell invasion at 10 μM. These results highlight sipholane triterpenoids as novel antimigratory marine natural products with potential for further development as agents for the control of metastatic breast malignancies.
An event view specification approach for Supporting Service process collaboration
Authors: Cao Jian , Wang Jie , Zhao Haiyan , Li Minglu 
Published: February 2013

ABSTRACTDesigning and implementing an interoperable and flexible service process collaboration strategy is one of key issues for business to business integrations. To better support service process collaboration, an event view model is proposed, which is composed of a set of event types and their dependency relationships. It provides a general and flexible way to define a public view of a service process model and serves as the basis for defining service process collaboration protocols. In the paper, the basic concepts and a system framework for event‐based service process collaboration are first introduced. The definitions of event and the dependency relationships among event types are then presented. Especially, how to identify dependency relationships among composite event types is studied in detail. After discussing the definition of event view and its specifying approach, a procedure for transforming a BPEL process model into an event model and deriving dependencies among events is given. Finally, a case study is presented, and some implementation issues for defining and publishing an event view are discussed. Copyright © 2013 John Wiley & Sons, Ltd.
Fractionation of Organosolv Lignin from Olive Tree Clippings and its Valorization to Simple Phenolic Compounds
Authors: Toledano Ana , Serrano Luis , Balu Alina Mariana , Luque Rafael , Pineda Antonio , Labidi Jalel 
Published: February 2013

AbstractLignin valorization practices have attracted a great deal of interest in recent years due to the large excess of lignin produced by the pulp and paper industry, together with second‐generation bioethanol plants. In this work, a new lignin valorization approach is proposed. It involves ultrafiltration as a fractionation process to separate different molecular weight lignin fractions followed by a hydrogen‐free, mild, hydrogenolytic, heterogeneously catalyzed methodology assisted by microwave irradiation to obtain simple phenolic, monomeric products by depolymerization using a nickel‐based catalyst. The main products obtained were desaspidinol, syringaldehyde, and syringol; this proves the efficiency of the depolymerization conditions applied. The concentration of these observed compounds increased when the molecular weights of the lignin fractions increased. The applied depolymerization conditions, which take advantage of the use of formic acid as a hydrogen‐donating solvent, did not generate any biochar in the systems.
Alumina and Yttria Powder and Yttria Coatings Made by Ultrasonic Spray Pyrolysis
Authors: Santos Abreu Alexandre , Knoll Matthias , Moosburger‐Will Judith , Konrad Armin , Tidecks Reinhard , Horn Siegfried 
Published: February 2013

AbstractUltrasonic spray pyrolysis is used to produce metal oxide powders (alumina, yttria, and mixtures of these) from nitrate precursors at temperatures below 500 °C. Moreover, yttria powder coatings on soda‐lime glass and fused silica substrates are generated. The as‐prepared powders and coatings are examined using scanning electron microscopy (SEM), energy dispersive X‐ray (EDX) analysis, X‐ray diffraction (XRD), and transmission electron microscopy (TEM).
MOCVD of C‐oriented Bi2Te3 Films on SiO2 Substrates using Triethyl Bismuth and Di‐tertiarybutyl Tellurium
Authors: Kang Sang‐Woo , Jeon Ki‐Moon , Shin Jae‐Soo , Chun Je‐Ran , Kim Young‐Heon , Lee Sang Jun , Yun Ju‐Young 
Published: February 2013

AbstractMetal‐organic (MO)CVD of bismuth telluride thin films is investigated by using a combination of optimized bismuth and tellurium precursors along with H2 as a reactant gas. Good quality films are obtained, even at 300 °C. The Bi precursors are trimethyl bismuth (Bi(CH3)3, Bi(Me3)) and triethyl bismuth (Bi(C2H5)3, Bi(Et)3), and the Te precursors are diethyl tellurium (Te(C2H5)2, Te(Et)2), di‐isopropyl tellurium (Te(C3H7)2, Te(iPr)2), and di‐tertiarybutyl tellurium (Te(C4H9)2, Te(tBu)2). The integrated absorbance area of C‐H stretching vibrations in the range 2800–3200 cm−1 is estimated to determine the decomposition rate of the Bi and Te precursors. C‐oriented Bi2Te3 films are obtained at 300 °C and under 2.5 Torr using Bi(Et)3 and Te(tBu)2 and characterized. Further, the microstructure, crystallinity, and surface morphology of the films are determined. The appropriate stoichiometry of the bismuth telluride films is obtained as Bi/Te = 2:3. The combination of Bi(Et)3 and Te(tBu)2 is the most effective for low‐temperature deposition because, compared to the other precursors, the decomposition of these precursors starts at a lower temperature. Investigations of the precursor decomposition behavior show that the absorbance of C‐H stretching vibrations of ligands in precursors in the gas phase is sensitive to the analysis conditions.
Col‐F, a fluorescent probe for ex vivo confocal imaging of collagen and elastin in animal tissues
Authors: Biela Ewa , Galas Jerzy , Lee Brian , Johnson Gary L. , Darzynkiewicz Zbigniew , Dobrucki Jurek W. 
Published: February 2013

AbstractA new low‐molecular‐weight fluorescent probe, Col‐F, that exhibits affinity to collagen and elastin, was used successfully in imaging of extracellular matrix in freshly excised animal tissues. Col‐F readily penetrates between live cells into tissues and binds to fibers of collagen and elastin by a noncovalent mechanism. Fibers of collagen and elastin have been stained in a variety of tissues, including tendon, skeletal muscle, connective tissue, and arteries. Cells migrating in a Col‐F‐stained collagenous biomaterial were also imaged. No phototoxic effects were detected when live keratocytes were imaged in the in vitro culture in the presence of Col‐F. In conclusion, Col‐F provides a simple and convenient tool for fluorescence three‐dimensional imaging of intricate collagenous and elastic structures in live and fixed animal tissues, as well as in collagen‐containing biomaterials. © 2013 International Society for Advancement of Cytometry
The effects of sustained forest use on hillslope soil hydraulic conductivity in the Middle Mountains of Central Nepal
Authors: Ghimire Chandra Prasad , Bruijnzeel L. Adrian , Bonell Mike , Coles Neil , Lubczynski Maciek W. , Gilmour Don A. 
Published: February 2013

ABSTRACTThis work investigated the multi‐decadal changes in field saturated hydraulic conductivity, Kfs, beneath severely degraded pasture, natural forest and two mature planted Pinus roxburghii stands between two sets of measurements made in 1986 and 2011 at the same locations in the Middle Mountains of Central Nepal. Multiple measurements of Kfs were made at the four sites, both at the surface and at depths of 0·05–0·15, 0·15–0·25 and 0·25–0·50 m. The Kfs results were subsequently combined with rainfall intensities associated with different time intervals to infer multi‐decadal changes in dominant hillslope stormflow pathways.The widely assumed hydrological benefits of reforesting degraded land through the enhancement of near‐surface permeability due to such factors as the incorporation of a greater amount of organic matter, formation of macropores, as well as root development were not observed in this study. Continued heavy use of the natural and planted forests of the Middle Mountains, particularly the removal of understory vegetation and leaf litter, and cattle grazing, are considered to be the chief causal factors of the presently observed deterioration in forest hydrological functioning. This situation is typical not only of the Middle Mountain Zone across the Himalaya but is also observed in other densely populated parts of South and South‐East Asia.The key conclusion of this work is that simply planting trees in degraded landscapes is not sufficient in itself to restore watershed hydrological functioning. Attention also needs to be given to on‐going management of the reforested areas to balance product usage with watershed functions. Copyright © 2013 John Wiley & Sons, Ltd.
trans‐1,2‐Diphenylethylene Linked Isoindoline–Salicylaldiminato Nickel(II) Halide Complexes: Synthesis, Structure, Dehydrogenation, and Catalytic Activity toward Olefin Homopolymerization
Authors: Wang Jinyang , Wan Li , Zhang Dao , Wang Quanrui , Chen Zhenxia 
Published: February 2013

AbstractTridentate ligands 4‐R1‐6‐R2‐2‐{[trans‐2‐(isoindolin‐2‐yl)‐1,2‐diphenylethylimino]methyl}phenol [R1 = R2 = H, H(La); R1 = R2 = tert‐butyl, H(Lb); R1 = Ph, R2 = H, H(Lc)] in which a substituted salicylaldimine moiety and an isoindoline are linked by a trans‐1,2‐diphenylethylene moiety have been prepared. Deprotonation of these tridentate ligands H(La)–H(Lc) by NaH at room temperature in tetrahydrofuran (THF), followed by treatment with 1 equiv. of [(PPh3)2NiX2] (X = Cl, Br, I) at room temperature afforded the desired nickel complexes [(L)NiX] (X = Cl, L = La, 1; X = Cl, L = Lb, 2; X = Cl, L = Lc, 3; X = Br, L = Lb, 4; X = I, L = Lb, 5) in moderate yields. The structures of 2 and 4 were unequivocally confirmed by single‐crystal X‐ray diffraction in the solid state. The metal atom has a distorted square‐planar coordination geometry and is coordinated to the two nitrogen atoms and one oxygen atom from the tridentate ligand and one halide atom. Dehydrogenation of the chelate tridentate ligand (Lb) in the presence of oxygen afforded the corresponding nickel complexes [(Lb*)NiX] (X = Br, 6; X = I, 7). X‐ray analysis showed that in these complexes the two bridged benzylic carbon atoms of (Lb)– were oxidized and a cis‐stilbene moiety, which includes a C=C double bond (1.205–1.268 Å) was formed. These nickel complexes with such trans‐1,2‐diphenylethylene bridged tridentate ligands proved to be active catalysts for ethylene oligomerization in the presence of methylaluminoxane (MAO) and produced butene and hexene with catalytic activities of 0.49 × 105–3.25 × 105 g mol–1 Ni h–1 at 30 °C, under 20 bar of ethylene, and with an MAO/Ni ratio of 250. They were also active catalysts for the homopolymerization of norbornene and styrene and displayed activities of up to 1.89 × 105 and 7.36 × 105 g mol–1 Ni h–1, respectively.
The galactolipase activity of some microbial lipases and pancreatic enzymes
Authors: Amara Sawsan , Lafont Dominique , Parsiegla Goetz , Point Vanessa , Chabannes Aurélie , Rousset Audric , Carrière Frédéric 
Published: February 2013

AbstractSeveral well known microbial lipases were screened for their ability to hydrolyze synthetic medium chain monogalactosyldiacylglycerol (MGDG) and digalactosyldiacylglycerol (DGDG). Fusarium solani cutinase and Thermomyces lanuginosus lipase (TLL) were found to hydrolyze MGDG at high rates (984 ± 62 and 450 ± 41 U/mg, respectively). These activities remained however lower than those measured with pancreatic lipase‐related protein 2 (PLRP2) on the same substrate. As previously observed with PLRP2, galactolipid–bile salt mixed micelles were found to be the best substrate form for microbial enzymes. The galactolipid to bile salt molar ratios for measuring maximum galactolipase activities were found to be similar to those previously established with PLRP2, suggesting that bile salts have mainly an effect on the substrate and not on the enzyme itself. The galactolipase activity of cutinase and TLL, as well as human and guinea pig PLRP2s were also measured using galactolipid monomolecular films. Enzymes having a lid (TLL and human PLRP2) were found to act at higher surface pressures than those with no lid (cutinase and guinea pig PLRP2). In silico docking of medium chain MGDG and DGDG in the active site of guinea pig PLRP2 and TLL reveals some structural analogies between these enzymes.Practical applications: Galactolipase activity already finds applications in baking process with the partial lipolysis of galactolipids present in wheat flour and the in situ production of emulsifier molecules. More generally, these enzymes could be used for the enzymatic modification of galactolipids, the main plant lipids. These lipids are considered to be the most abundant at the surface of the earth and thus constitute the largest resource of fatty acids.
Efficient and First Regio‐ and Stereoselective Direct C‐Glycosylation of a Flavanone Catalysed by Pr(OTf)3 Under Conventional Heating or Ultrasound Irradiation
Authors: Santos Rui G. , Xavier Nuno M. , Bordado João C. , Rauter Amélia P. 
Published: February 2013

AbstractA simple, regio‐ and stereoselective one‐step methodology for the mono‐C‐glycosylation of flavanone has been established. Naringenin was directly C‐glycosylated with D‐glucose by catalysis with rare‐earth metal triflates in acetonitrile/water. Different reaction conditions, namely the solvent system, reaction time, energy source and catalyst were studied. Commercially available lanthanide triflates were evaluated as catalysts and praseodymium triflate proved to be the most effective for this coupling reaction. The optimized reaction conditions were applied to other monosaccharidyl donors, such as D‐mannose, D‐galactose and L‐rhamnose, as well as disaccharides, such as lactose and maltose, leading regio‐ and stereoselectively to 8‐C‐glycosyl derivatives with equatorial glycosidic bonds in yields ranging from 28 to 38 %. Ultrasound irradiation was used to enhance the reaction outcome and a considerable improvement in reaction time and efficiency was achieved, allowing selective access to the target C‐glycosylflavanones in yields of 43–56 %.
Iodoetherification of Isosorbide‐Derived Glycals: Access to a Variety of O‐Alkyl or O‐Aryl Isosorbide Derivatives
Authors: Berini Christophe , Lavergne Aurélie , Molinier Valérie , Capet Frédéric , Deniau Eric , Aubry Jean‐Marie 
Published: February 2013

AbstractA set of O‐alkylated or O‐arylated β‐iodo ethers has been synthesized from isosorbide. Isosorbide is a competitive starting material for various valuable derivatives by functionalization and/or substitution since it is a renewable and carbon neutral material that is produced on an industrial scale from sorbitol. The key step was the iodoetherification of isosorbide‐derived glycals with a variety of oxygenated nucleophiles in the presence of N‐iodosuccinimide. trans‐Iodo ethers and acetate were obtained in good yields and the removal of iodide affords isosorbide derivatives. The usefulness of this new approach is illustrated by the synthesis of a surfactant having a dimer of isosorbide as hydrophilic group and by the preparation of a structurally unusual bicyclic anhydro carbohydrate.
Closer look at the operating definition of protein recovery in CE
Authors: Espinal Jose H. , Gómez Jorge E. , Sandoval Junior E. 
Published: February 2013

Analyte recovery is an important figure to assess protein adsorption on fused‐silica capillaries. In 1991, Regnier et al. estimated recovery by assuming the loss of analyte from adsorption and thus the decrease in peak area measured by two detectors to be proportional to the length of the capillary section between them. In this report, we closely examine this concept and its adaptation to commercial CE instruments to determine protein recovery. We hypothesize that, once a steady‐state migration is reached, protein adsorption is a first‐order process with respect to protein concentration and surface density of adsorbing sites. This hypothesis is shown to be valid over a reasonably wide range of capillary effective length and, as a result, protein recovery decreases exponentially with the migrated distance. However, unlike the traditional recovery figure obtained through a conventional spike process, protein recovery measured by this approach does not have the same merit since it is strongly dependent from capillary dimensions and applied electric field. Nevertheless, protein recovery and the slope of the logarithmic protein peak area versus length plot are useful figures to compare protein adsorption on different capillary surfaces. Several literature reports dealing with the application of Regnier concept to calculate protein recovery are discussed.