bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association of the hemoglobin, albumin, lymphocyte, and platelet score with the risk of Erectile dysfunction: a cross-sectional study
Authors: Chen Di , Chen Jinji , Zhou Qiufeng , Mi Hua , Liu Gang 
Published: July 2024

AbstractErectile dysfunction (ED) is related to nutritional and inflammatory factors. The hemoglobin, albumin, lymphocyte, and platelet score (HALP), a new index reflecting the nutritional and inflammatory status, has been associated with a higher risk of diabetic retinopathy, particularly at lower values (≤ 42.9). However, studies focusing on the relationship between HALP and ED risk are scarce. Hence, this study aimed to investigate the association between HALP and ED. Data were extracted from the National Health and Nutrition Examination Survey (NHANES) conducted between 2001 and 2004. Based on self-reported data, participants were classified into either the ED group or the non-ED group. Next, the HALP score was categorized into four quartiles (Q1–4). Weighted multivariate regression analysis was performed to assess the relationship between categorical HALP and ED risk. Additionally, restricted cubic spline (RCS) analysis was conducted to examine the association between continuous HALP scores and ED risk. Furthermore, subgroup analyses were conducted to examine the association between categorical HALP and the risk of ED based on age, as well as the status of hypertension, diabetes and cardiovascular disease. Finally, a mediation analysis was carried out to investigate the mediating effect of HALP and related parameters on the association between urinary cobalt levels and ED. Initially, the data of 21,161 participants were collected. After implementing the inclusion and exclusion criteria, 3406 participants were included in the final analyses. Weighted multivariate regression analysis demonstrated that the Q4 HALP group was associated with a lower risk of ED (OR 0.96, 95% confidence intervals 0.92–1.00, P = 0.037). Meanwhile, RCS analysis showed that HALP was nonlinearly associated with the risk of ED. In addition, subgroup analyses demonstrated that participants in the Q3/4 HALP group had a significantly lower ED risk than those in the Q1 group among patients aged ≥ 50 years, as well as those with hypertension and diabetes. Lastly, mediation analysis revealed that HALP and its associated parameters had a marginal average causal mediation effect on the relationship between urinary cobalt levels and ED risk (P > 0.05). In US adults, high HALP scores were correlated with a lower risk of ED. The relationship was more pronounced in participants aged ≥ 50 years with hypertension and diabetes. Furthermore, HALP and its parameters may not mediate the association between urinary cobalt levels and ED risk.
Exploring the chaotic structure and soliton solutions for (3 + 1)-dimensional generalized Kadomtsev–Petviashvili model
Authors: Nadeem Muhammad , Jingxia Ding , Tariq Kalim U. , Alsayaad Yahya 
Published: July 2024

AbstractThe study of the Kadomtsev–Petviashvili (KP) model is widely used for simulating several scientific phenomena, including the evolution of water wave surfaces, the processes of soliton diffusion, and the electromagnetic field of transmission. In current study, we explore some multiple soliton solutions of the (3+1)-dimensional generalized KP model via applying modified Sardar sub-equation approach (MSSEA). By extracting the novel soliton solutions, we can effectively obtain singular, dark, combo, periodic and plane wave solutions through a multiple physical regions. We also investigate the chaotic structure of governing model using the chaos theory. The behavior of the collected solutions is visually depicted to demonstrate the physical properties of the proposed model. The solutions obtained in this paper can expand the existing solutions of the (3+1)-dimensional KP model and enhance our understanding of the nonlinear dynamic behaviors. This approach allows for consistent and effective treatment of the computation process for nonlinear KP model.
Development of maximum relevant prior feature ensemble (MRPFE) index to characterize future drought using global climate models
Authors: Gul Atta , Qamar Sadia , Yousaf Mahrukh , Ali Zulfiqar , Alshahrani Mohammed , Hilali Shreefa O. 
Published: July 2024

AbstractDrought is one of the foremost outcomes of global warming and global climate change. It is a serious threat to humans and other living beings. To reduce the adverse impact of drought, mitigation strategies as well as sound projections of extreme events are essential. This research aims to strengthen the robustness of anticipated twenty-first century drought by combining different Global Climate Models (GCMs). In this article, we develop a new drought index, named Maximum Relevant Prior Feature Ensemble index that is based on the newly proposed weighting scheme, called weighted ensemble (WE). In the application, this study considers 32 randomly scattered grid points within the Tibetan Plateau region and 18 GCMs of Coupled Model Intercomparison Project Phase 6 (CMIP6) of precipitation. In this study, the comparative inferences of the WE scheme are made with the traditional simple model averaging (SMA). To investigate the trend and long-term probability of various classes, this research employs Markov chain steady states probability, Mann–Kendall trend test, and Sen’s Slope estimator. The outcomes of this research are twofold. Firstly, the comparative inference shows that the proposed weighting scheme has greater efficiency than SMA to conflate GCMs. Secondly, the research indicates that the Tibetan Plateau is projected to experience “moderate drought (MD)” in the twenty-first century.
Multi-objective optimization of custom implant abutment design for enhanced bone remodeling in single-crown implants using 3D finite element analysis
Authors: Poovarodom Pongsakorn , Rungsiyakull Chaiy , Suriyawanakul Jarupol , Li Qing , Sasaki Keiichi , Yoda Nobuhiro , Rungsiyakull Pimduen 
Published: July 2024

Abstract
The optimal configuration of a customized implant abutment is crucial for bone remodeling and is influenced by various design parameters. This study introduces an optimization process for designing two-piece zirconia dental implant abutments. The aim is to enhance bone remodeling, increase bone density in the peri-implant region, and reduce the risk of late implant failure. A 12-month bone remodeling algorithm subroutine in finite element analysis to optimize three parameters: implant placement depth, abutment taper degree, and gingival height of the titanium base abutment. The response surface analysis shows that implant placement depth and gingival height significantly impact bone density and uniformity. The taper degree has a smaller effect on bone remodeling. The optimization identified optimal values of 1.5 mm for depth, 35° for taper, and 0.5 mm for gingival height. The optimum model significantly increased cortical bone density from 1.2 to 1.937 g/cm3 in 2 months, while the original model reached 1.91 g/cm3 in 11 months. The standard deviation of density showed more uniform bone apposition, with the optimum model showing values 2 to 6 times lower than the original over 12 months. The cancellous bone showed a similar trend. In conclusion, the depth and taper have a significant effect on bone remodeling. This optimized model significantly improves bone density uniformity.
Evaluation of the effect of vascularized fibula graft harvesting on coronal plane alignment and functional outcomes of the lower limb
Authors: Aydın Abdurrahman , Baydar Mehmet , Ünkar Ethem Ayhan , Erbaş Anıl , Üçpunar Hanifi , Yapıcı Furkan , Gür Volkan , Öztürk Kahraman 
Published: July 2024

AbstractRecent studies on fibular osteotomy for varus gonarthrosis and possible subsequent biomechanical changes have attracted increasing attention to the topic. Existing studies have focused mainly on proximal fibular osteotomy with short follow-up periods. The aim of this study was to investigate changes in the alignment of the coronal plane of the ankle and knee joints in patients who underwent vascularized fibula graft harvest (VFGH). The evaluation was based on functional outcomes and radiological measurements.In the comparison between the VFGH side and the contralateral side, no significant differences in the knee inclination (KI) or talar inclination (TI) angle, knee medial clear space (K-MCS) or ankle medial clear space (A-MCS) distance were noted. However, a significant difference in the hip knee (HKA) angle was observed between the operated and nonoperated sides (0.3° ± 1.8° and 1.5° ± 1.9°, respectively [p = 0.019]). Statistically significant differences in both the knee society score (KSS) and the AOFAS scores were found between the ipsilateral donor limb and the contralateral healthy limb. Although the contralateral healthy side had better clinical scores than the VFGH side, the outcomes of the VFGH side were still satisfactory or excellent.
Association between composite dietary antioxidant and bone mineral density in children and adolescents aged 8–19 years: findings from NHANES
Authors: Cui Aiyong , Yan Juan , Zeng Yuan , Shi Baoqiang , Cheng Long , Deng Hongli , Wei Xing , Zhuang Yan 
Published: July 2024

AbstractDietary antioxidants may have beneficial effects on bone health, but it remains uncertain in children and adolescents. This study investigates the association of composite dietary antioxidant index (CDAI) with bone mineral density (BMD) in children and adolescents aged 8–19 years from the National Health and Nutrition Examination Survey (NHANES) 2007–2010. The study assessed the relationship between CDAI and BMD in 2994 individuals aged 8–19 years (average age 13.48 ± 3.32 years) from the NHANES 2007–2010. Multivariate linear regression analyses were utilized to detect the association between CDAI and total spine, femur neck, and total femur BMD, adjusting for confounders including age, race/ethnicity, sex, poverty income ratio (PIR), body mass index (BMI), serum phosphorus and calcium. Stratified analyses and interaction tests were performed to examine the stability of the results. The weighted characteristics showed that subjects in the fourth CDAI quartile were more likely to be older, men, and Non-Hispanic White. They have higher values of serum total calcium and phosphorus. After adjusting all confounders, CDAI was positively associated with the total spine (β = 0.0031 95% CI 0.0021–0.0040), total femur (β = 0.0039 95% CI 0.0028–0.0049), and femur neck BMD (β = 0.0031 95% CI 0.0021–0.0040) in children and adolescents. Furthermore, we found no interaction effects between different race/ethnicity, age, and sex groups. Our findings suggest that dietary intake of multiple antioxidants was positively associated with BMD in children and adolescents. These findings provide valuable evidence for improving bone health in the early stages of life. However, more prospective studies are required to validate our findings and their causal relationship.
Severity predictors for multisystemic inflammatory syndrome in children after SARS-CoV-2 infection in Vietnam
Authors: Tran Dien. M. , Pham Dem. V. , Cao Tung. V. , Hoang Canh. N. , Nguyen Ha. T. T. , Nguyen Giang. D. , Le Cuong. N. , Thieu Quan. Q. , Ta Tuan. A. , Dau Hung. V. , Le Chi. Q. , Le Quang. H. , Luong Nghiem. T. , Tran Mai. T. , Nguyen Phu. H. , Nguyen Nhung. T. , Phan Phuc. H. 
Published: July 2024

AbstractMultisystemic inflammatory syndrome in children (MIS-C) might manifest in a broad spectrum of clinical scenarios, ranging from mild features to multi-organ dysfunction and mortality. However, this novel entity has a heterogenicity of data regarding prognostic factors associated with severe outcomes. The present study aimed to identify independent predictors for severity by using multivariate regression models. A total of 391 patients (255 boys and 136 girls) were admitted to Vietnam National Children’s Hospital from January 2022 to June 2023. The median age was 85 (range: 2–188) months, and only 12 (3.1%) patients had comorbidities. 161 (41.2%) patients required PICU admission, and the median PICU LOS was 4 (2–7) days. We observed independent factors related to PICU admission, including CRP $$\ge $$
≥
50 (mg/L) (OR 2.52, 95% CI 1.39–4.56, p = 0.002), albumin $$\le $$
≤
30 (g/L) (OR 3.18, 95% CI 1.63–6.02, p = 0.001), absolute lymphocyte count $$\le $$
≤
2 (× 109/L) (OR 2.18, 95% CI 1.29–3.71, p = 0.004), ferritin ≥ 300 (ng/mL) (OR 2.35, 95% CI 1.38–4.01), p = 0.002), and LVEF < 60 (%) (OR 2.48, 95% CI 1.28–4.78, p = 0.007). Shock developed in 140 (35.8%) patients, especially for those decreased absolute lymphocyte $$\le $$
≤
2 (× 109/L) (OR 2.48, 95% CI 1.10–5.61, p = 0.029), albumin $$\le $$
≤
30 (g/L) (OR 2.53, 95% CI 1.22–5.24, p = 0.013), or LVEF < 60 (%) (OR 2.24, 95% CI 1.12–4.51, p = 0.022). In conclusion, our study emphasized that absolute lymphocyte count, serum albumin, CRP, and LVEF were independent predictors for MIS-C severity. Further well-designed investigations are required to validate their efficacy in predicting MIS-C severe cases, especially compared to other parameters. As MIS-C is a new entity and severe courses may progress aggressively, identifying high-risk patients optimizes clinicians' follow-up and management to improve disease outcomes.
Clinical significance of PLT for diagnosis and treatment monitoring in imported malaria
Authors: Fu Shui , Hu Qi-Lei , Zhang Liang , Han Xiao-Jun 
Published: July 2024

AbstractTo evaluate the clinical significance of PLT, MPV, and PDW in monitoring malaria treatment efficacy and predicting disease progression. A total of 31 patients with imported malaria were selected as the observation group, while 31 non-malaria patients with fever were selected as controls. The observation group was subdivided into a complication group and a non-complication group according to the occurrence of complications during treatment. Additionally, on the 1st day (within 24 h), the 3rd day, and the 5th day following admission, a comprehensive blood routine examination, Plasmodium microscopic examination, and colloidal gold assay were conducted. The blood routine examination results were compared before and after treatment among patients in the observation group and the control group. Moreover, the study involved dynamic monitoring and analysis of the levels and variations in PLT, MPV, and PDW within both the complication group and the non-complication group. The Plasmodium density was negatively correlated with PLT before treatment. There were significant differences were observed in PLT, MPV, and PDW (P < 0.05) within the observation group before and after treatment. Notably, there were no significant alterations in red blood cell (RBC), hemoglobin (Hb), and white blood cell (WBC) counts (P > 0.05) within the observation group before and after treatment. The PLT, MPV, and PDW levels in the complication group and the non-complication group exhibited an upward trend after treatment. Further, the PLT of patients in the complication group was significantly lower than that in the non-complication group. Additionally, the PLT, MPV, and PDW levels in the complication group and the non-complication group increased gradually from the time of admission to the 3rd and 5th day of treatment. Notably, the PLT in the complication group was consistently lower than that in the non-complication group. The continuous monitoring of PLT, MPV, and PDW changes plays a crucial role in assessing malaria treatment efficacy and prognosis in these individuals.
High precision in epileptic seizure self-reporting with an app diary
Authors: Zabler Nicolas , Swinnen Lauren , Biondi Andrea , Novitskaya Yulia , Schütz Elisa , Epitashvili Nino , Dümpelmann Matthias , Richardson Mark P. , Van Paesschen Wim , Schulze-Bonhage Andreas , Hirsch Martin 
Published: July 2024

AbstractPeople with epilepsy frequently under- or inaccurately report their seizures, which poses a challenge for evaluating their treatment. The introduction of epilepsy health apps provides a novel approach that could improve seizure documentation. This study assessed the documentation performance of an app-based seizure diary and a conventional paper seizure diary. At two tertiary epilepsy centers patients were asked to use one of two offered methods to report their seizures (paper or app diary) during their stay in the epilepsy monitoring unit. The performances of both methods were assessed based on the gold standard of video-EEG annotations. In total 89 adults (54 paper and 35 app users) with focal epilepsy were included in the analysis, of which 58 (33 paper and 25 app users) experienced at least one seizure and made at least one seizure diary entry. We observed a high precision of 85.7% for the app group, whereas the paper group’s precision was lower due to overreporting (66.9%). Sensitivity was similar for both methods. Our findings imply that performance of seizure self-reporting is patient-dependent but is more precise for patients who are willing to use digital apps. This may be relevant for treatment decisions and future clinical trial design.
SnapFISH-IMPUTE: an imputation method for multiplexed DNA FISH data
Authors: Yu Hongyu , Wu Daiqing , Mishra Shreya , Shen Guning , Sun Huaigu , Hu Ming , Li Yun 
Published: July 2024

AbstractChromatin spatial organization plays a crucial role in gene regulation. Recently developed and prospering multiplexed DNA FISH technologies enable direct visualization of chromatin conformation in the nucleus. However, incomplete data caused by limited detection efficiency can substantially complicate and impair downstream analysis. Here, we present SnapFISH-IMPUTE that imputes missing values in multiplexed DNA FISH data. Analysis on multiple published datasets shows that the proposed method preserves the distribution of pairwise distances between imaging loci, and the imputed chromatin conformations are indistinguishable from the observed conformations. Additionally, imputation greatly improves downstream analyses such as identifying enhancer-promoter loops and clustering cells into distinct cell types. SnapFISH-IMPUTE is freely available at https://github.com/hyuyu104/SnapFISH-IMPUTE.
A-to-I RNA co-editing predicts clinical outcomes and is associated with immune cells infiltration in hepatocellular carcinoma
Authors: Chen Juan , Zhang Cheng-Hui , Tao Tao , Zhang Xian , Lin Yan , Wang Fang-Bin , Liu Hui-Fang , Liu Jian 
Published: July 2024

AbstractAberrant RNA editing has emerged as a pivotal factor in the pathogenesis of hepatocellular carcinoma (HCC), but the impact of RNA co-editing within HCC remains underexplored. We used a multi-step algorithm to construct an RNA co-editing network in HCC, and found that HCC-related RNA editings are predominantly centralized within the network. Furthermore, five pairs of risk RNA co-editing events were significantly correlated with the overall survival in HCC. Based on presence of risk RNA co-editings resulted in the categorization of HCC patients into high-risk and low-risk groups. Disparities in immune cell infiltrations were observed between the two groups, with the high-risk group exhibiting a greater abundance of exhausted T cells. Additionally, seven genes associated with risk RNA co-editing pairs were identified, whose expression effectively differentiates HCC tumor samples from normal ones. Our research offers an innovative perspective on the etiology and potential therapeutics for HCC.
Moderate beta-cell ablation triggers synergic compensatory mechanisms even in the absence of overt metabolic disruption
Authors: Mathisen Andreas Frøslev , Larsen Ulrik , Kavli Natalie , Unger Lucas , Daian Laura Maria , Vacaru Andrei Mircea , Vacaru Ana-Maria , Herrera Pedro Luis , Ghila Luiza , Chera Simona 
Published: July 2024

AbstractRegeneration, the ability to replace injured tissues and organs, is a phenomenon commonly associated with lower vertebrates but is also observed in mammals, in specific tissues. In this study, we investigated the regenerative potential of pancreatic islets following moderate beta-cell loss in mice. Using a rapid model of moderate ablation, we observed a compensatory response characterized by transient inflammation and proliferation signatures, ultimately leading to the recovery of beta-cell identity and function. Interestingly, this proliferative response occurred independently of inflammation, as demonstrated in ablated immunodeficient mice. Furthermore, exposure to high-fat diet stimulated beta-cell proliferation but negatively impacted beta-cell function. In contrast, an equivalent slower ablation model revealed a delayed but similar proliferative response, suggesting proliferation as a common regenerative response. However, high-fat diet failed to promote proliferation in this model, indicating a differential response to metabolic stressors. Overall, our findings shed light on the complex interplay between beta-cell loss, inflammation, and stress in modulating pancreatic islet regeneration. Understanding these mechanisms could pave the way for novel therapeutic strategies based on beta-cell proliferation.
A successive variational mode extraction method based on spectrum trend and its application in non‐contact vital sign detection
Authors: Zhao Qianxi , Sheng Zhichao , He Guoqiang , Yu Hongwen , Fang Yong 
Published: July 2024

AbstractDetecting respiration and heartbeat information from human chest movement is crucial for non‐contact vital sign detection. Due to the small frequency difference between respiration and heartbeat signals and the relatively low amplitude of the heartbeat signal, it is challenging to separate and extract them completely. This letter proposes a successive variational mode extraction method based on spectrum trend for the extraction of respiration and heartbeat signals. The proposed method adaptively determines the initial centre frequency and extraction order of the desired signal modes by analyzing the spectrum trend of the signal to be decomposed. Additionally, a recursive framework is introduced to sequentially extract the desired signal modes. Both simulation and practical experiment results show that the method is effective in extracting respiration and heartbeat signals, significantly improving the accuracy of estimating respiration and heartbeat frequencies.
A smooth method for primary frequency of wind turbine based on variable power point tracking and energy storage cooperative control
Authors: Cui Sen , Siddique Abubakar , Aslam Waseem , Alamri Atif M. , AlQahtani Salman A. 
Published: July 2024

AbstractThe conventional deloading control has certain problems, such as low power generation efficiency and a small speed adjustment range. To improve the system's frequency quality and enhance the power grid's stability, this study comprehensively considers the effect of random source‐load power fluctuations on the system frequency. Moreover, this study proposes a smooth primary frequency control strategy for wind turbine based on the coordinated control of the variable power point tracking and supercapacitor energy storage. The impact of wind power fluctuations on the system frequency at different timescales for wind turbine is studied based on the historical data of wind power fluctuations in a strong wind meteorological cycle of a wind farm. The method determines the capacity of the energy storage device required for frequency smoothing at the optimal timescale. In combination with the required capacity of the wind turbine to participate in the system's primary frequency regulation, the supercapacitor energy storage device is optimally configured, and a set of supercapacitor energy storage device with the lowest cost under the highest charging/discharging efficiency is designed. Simulation and experimental results show that the primary frequency adjustment capability of the control strategy proposed in this study is significantly improved compared with the conventional primary frequency modulation control.