bluuebunny/crossref_metadata_2025_split huggingface dataset:
Brivanib Versus Sorafenib As First-Line Therapy in Patients With Unresectable, Advanced Hepatocellular Carcinoma: Results From the Randomized Phase III BRISK-FL Study
Authors: Johnson Philip J. , Qin Shukui , Park Joong-Won , Poon Ronnie T.P. , Raoul Jean-Luc , Philip Philip A. , Hsu Chih-Hung , Hu Tsung-Hui , Heo Jeong , Xu Jianming , Lu Ligong , Chao Yee , Boucher Eveline , Han Kwang-Hyub , Paik Seung-Woon , Robles-Aviña Jorge , Kudo Masatoshi , Yan Lunan , Sobhonslidsuk Abhasnee , Komov Dmitry , Decaens Thomas , Tak Won-Young , Jeng Long-Bin , Liu David , Ezzeddine Rana , Walters Ian , Cheng Ann-Lii 
Published: August 2013

Purpose Brivanib is a dual inhibitor of vascular-endothelial growth factor and fibroblast growth factor receptors that are implicated in the pathogenesis of hepatocellular carcinoma (HCC). Our multinational, randomized, double-blind, phase III trial compared brivanib with sorafenib as first-line treatment for HCC. Patients and Methods Advanced HCC patients who had no prior systemic therapy were randomly assigned (ratio, 1:1) to receive sorafenib 400 mg twice daily orally (n = 578) or brivanib 800 mg once daily orally (n = 577). Primary end point was overall survival (OS). Secondary end points included time to progression (TTP), objective response rate (ORR), disease control rate (DCR) based on modified Response Evaluation Criteria in Solid Tumors (mRECIST), and safety. Results The primary end point of OS noninferiority for brivanib versus sorafenib in the per-protocol population (n = 1,150) was not met (hazard ratio [HR], 1.06; 95.8% CI, 0.93 to 1.22), based on the prespecified margin (upper CI limit for HR ≤ 1.08). Median OS was 9.9 months for sorafenib and 9.5 months for brivanib. TTP, ORR, and DCR were similar between the study arms. Most frequent grade 3/4 adverse events for sorafenib and brivanib were hyponatremia (9% and 23%, respectively), AST elevation (17% and 14%), fatigue (7% and 15%), hand-foot-skin reaction (15% and 2%), and hypertension (5% and 13%). Discontinuation as a result of adverse events was 33% for sorafenib and 43% for brivanib; rates for dose reduction were 50% and 49%, respectively. Conclusion Our study did not meet its primary end point of OS noninferiority for brivanib versus sorafenib. However, both agents had similar antitumor activity, based on secondary efficacy end points. Brivanib had an acceptable safety profile, but was less well-tolerated than sorafenib.
Comparison of Outcomes After Fluorouracil-Based Adjuvant Therapy for Stages II and III Colon Cancer Between 1978 to 1995 and 1996 to 2007: Evidence of Stage Migration From the ACCENT Database
Authors: Shi Qian , Andre Thierry , Grothey Axel , Yothers Greg , Hamilton Stanley R. , Bot Brian M. , Haller Daniel G. , Van Cutsem Eric , Twelves Chris , Benedetti Jacqueline K. , O'Connell Michael J. , Sargent Daniel J. 
Published: August 2013

Purpose With improved patient care, better diagnosis, and more treatment options after tumor recurrence, outcomes after fluorouracil (FU) -based treatment are expected to have improved over time in early-stage colon cancer. Data from 18,449 patients enrolled onto 21 phase III trials conducted from 1978 to 2002 were evaluated for potential differences in time to recurrence (TTR), time from recurrence to death (TRD), and overall survival (OS) with regard to FU-based adjuvant regimens. Methods Trials were predefined as old versus newer era using initial accrual before or after 1995. Outcomes were compared between patients enrolled onto old- or newer-era trials, stratified by stage. Results Within the first 3 years, recurrence rates were lower in newer- versus old-era trials for patients with stage II disease, with no differences among those with stage III disease. Both TRD and OS were significantly longer in newer-era trials overall and within each stage. The lymph node (LN) ratio (ie, number of positive nodes divided by total nodes harvested) in those with stage III disease declined over time. TTR improved slightly, with larger number of LNs examined in both stages. Conclusion Improved TRD in newer trials supports the premise that more aggressive intervention (oxaliplatin- and irinotecan-based chemotherapy and/or surgery for recurrent disease) improves OS for patients previously treated in the adjuvant setting. Lower recurrence rates with identical treatments in those with stage II disease enrolled onto newer-era trials reflect stage migration over time, calling into question historical data related to the benefit of FU-based adjuvant therapy in such patients.
Stomach Cancer Risk After Treatment for Hodgkin Lymphoma
Authors: Morton Lindsay M. , Dores Graça M. , Curtis Rochelle E. , Lynch Charles F. , Stovall Marilyn , Hall Per , Gilbert Ethel S. , Hodgson David C. , Storm Hans H. , Johannesen Tom Børge , Smith Susan A. , Weathers Rita E. , Andersson Michael , Fossa Sophie D. , Hauptmann Michael , Holowaty Eric J. , Joensuu Heikki , Kaijser Magnus , Kleinerman Ruth A. , Langmark Frøydis , Pukkala Eero , Vaalavirta Leila , van den Belt-Dusebout Alexandra W. , Fraumeni Joseph F. , Travis Lois B. , Aleman Berthe M. , van Leeuwen Flora E. 
Published: August 2013

Purpose Treatment-related stomach cancer is an important cause of morbidity and mortality among the growing number of Hodgkin lymphoma (HL) survivors, but risks associated with specific HL treatments are unclear. Patients and Methods We conducted an international case-control study of stomach cancer nested in a cohort of 19,882 HL survivors diagnosed from 1953 to 2003, including 89 cases and 190 matched controls. For each patient, we quantified cumulative doses of specific alkylating agents (AAs) and reconstructed radiation dose to the stomach tumor location. Results Stomach cancer risk increased with increasing radiation dose to the stomach (Ptrend < .001) and with increasing number of AA-containing chemotherapy cycles (Ptrend = .02). Patients who received both radiation to the stomach ≥ 25 Gy and high-dose procarbazine (≥ 5,600 mg/m2) had strikingly elevated stomach cancer risk (25 cases, two controls; odds ratio [OR], 77.5; 95% CI, 14.7 to 1452) compared with those who received radiation < 25 Gy and procarbazine < 5,600 mg/m2 (Pinteraction < .001). Risk was also elevated (OR, 2.8; 95% CI, 1.3 to 6.4) among patients who received radiation to the stomach ≥ 25 Gy but procarbazine < 5,600 mg/m2; however, no procarbazine-related risk was evident with radiation < 25 Gy. Treatment with dacarbazine also increased stomach cancer risk (12 cases, nine controls; OR, 8.8; 95% CI, 2.1 to 46.6), after adjustment for radiation and procarbazine doses. Conclusion Patients with HL who received subdiaphragmatic radiotherapy had dose-dependent increased risk of stomach cancer, with marked risks for patients who also received chemotherapy containing high-dose procarbazine. For current patients, risks and benefits of exposure to both procarbazine and subdiaphragmatic radiotherapy should be weighed carefully. For patients treated previously, GI symptoms should be evaluated promptly.
O Trabalho de Salvação de Cada Um
Authors: Silva Bernardo Melgaço da 
Published: August 2013

Quando eu fazia Terapias Holísticas, no Rio de Janeiro, tomei conhecimento de um conto muito interessante. E começava assim...Era uma vez um escritor que necessitando de paz para concentração na confecção de um livro que estava escrevendo alugou uma casa bem próxima de uma praia praticamente deserta. De sua janela dava para ver a areia da praia e as ondas do mar. E logo que começou a morar na casa, colocou sua escrivaninha próxima à janela de tal forma que dava para ver a beleza das ondas do mar. Certa vez, avistou bem longe um homem que fazia um gesto muito estranho. Ele aguçou o seu olhar mas como era muito longe – mesmo! – só via uma figura humana se abaixando como se estivesse fazendo uma ginástica ou um ritual com os braços lançando algo em direção ao mar. Ele ficou curioso com a cena. E decidiu constatar o fenômeno. Saiu de casa e seguiu caminhando pela areia da praia. Caminhou centenas de metros e na medida que ía se aproximando do estranho, a cena ficava mais nítida. E logo que se aproximou do homem, indagou ao estranho: “O que senhor está fazendo?”. O estranho, então, respondeu: “O senhor pode ver que a praia está cheia de estrelas-do-mar encalhadas na areia. Eu estou tentando salvá-las devolvendo-as ao mar”. O escritor respondeu dizendo: “O que adianta o senhor fazer isso se são milhares que estão encalhadas e nem todas poderão ser salvas”.
Análise Bioenergética: Uma Revisão Sistemática da Literatura
Authors: Oliveira Gislene Farias de , Silva Regina Coeli Araújo da , Rolim Solange Gonçalves 
Published: August 2013

A análise bioenergética é uma proposta de compreensão da personalidade à partir do corpo, dos seus movimentos e de seus processos energéticos. Respiração, expressão à partir dos movimentos, descarga energética e acumulação de energia são funções naturais do corpo, ao tempo que são expressões dos nossos sentimentos. A análise bioenergética parte do princípio de que o corpo e a mente funcionam de maneira semelhante e se auto-influenciam mutuamente. O presente estudo é uma revisão sistemática da literatura, com a finalidade de identificar e discutir pesquisas científicas relacionadas a análise bioenergética, produzidas na última década e disponíveis em periódicos científicos. A busca bibliográfica foi realizada a partir da consulta em artigos indexados às bases de dados Medline, Scielo e Lilacs, contendo as palavras-chave (e suas associações): “Bioenergética, psicologia corporal”. Os resultados nos levaram a crer que ainda é incipiente os artigos disponíveis em periódicos indexados no Brasil. Espera-se que este estudo possa despertar um maior interesse em divulgar estudos sobre essa temática, de maneira que, mais e mais pessoas possam se beneficiar dos conhecimentos desta importante teoria. Também que novos estudos sejam realizados, com um maior controle e rigor metodológicos, de forma a reafirmar os resultados benéficos da utilização dos princípios da Psicologia Corporal e da Análise Bioenergética.
Reflexões sobre o Medo: Aspectos históricos e contextuais
Authors: Lobo Karla Rossana Gomes , Neves Fernanda Pereira de Brito , Alencar Maria Carmem Batista de 
Published: August 2013

O medo é um tema recorrente na atualidade. Tem despertado a atenção das pessoas, por fazer parte do cotidiano social, ante as diversas mudanças que tem impactado a sociedade contemporânea, em suas diversas dimensões. O presente estudo discute o medo e suas implicações sociais e individuais, sob a ótica de diversos autores. A literatura estudada nos levou a crer que como consequência dos tempos atuais, de violência, de globalização e de constantes mudanças, o medo tem se tornado mais banal, parte do cotidiano junto a sentimentos mais exacerbados de desamparo nos indivíduos. Conhecer mais sobre nossas limitações talvez seja o início, na busca de uma estratégia para lidar com nossas experiências no mundo.
Terceira idade: Características e Políticas Públicas Associadas
Authors: Marinho Ana Olívia De Oliveira , Barroso Marianna Leite , Marinho Gisanne De Oliveira 
Published: August 2013

É notório o quanto o envelhecimento populacional vem crescendo graças à longevidade proporcionada pelos avanços da medicina. O envelhecimento é um fenômeno extremamente complexo, cujo conceito se deve a estrita interdependência dos aspectos biopsicosociais. Diversos estudos têm demonstrado uma associação entre envelhecimento e estados motivacionais depressivos. Embora se perceba uma melhora com relação à assistência aos idosos, associadas à uma maior participação dos mesmos em atividades voltadas para esta faixa etária e, a uma maior assistência por parte da implementação de diversos novos programas nas áreas assistenciais e de saúde, ainda é pequena a participação desses nos programas oferecidos. Sabemos que uma parcela significativa da população, principalmente no Nordeste do Brasil, encontra-se submetida a condições precárias de vida e, conseqüentemente, exposta a fatores de risco. Assim, a falta de atenção ao idoso e às suas problemáticas peculiares, parece ainda representar um problema de saúde pública no Brasil. Uma discussão sobre essa faixa etária e a efetividade de programas assistenciais para os mesmos, certamente ajudará na promoção de uma maior promoção de ações que considerem a melhoria do bem-estar desta parcela da população.
The Effects of Medicaid Earnings Limits on Earnings Growth among Poor Workers
Authors: Hamersma Sarah 
Published: August 2013

Abstract
Strict earnings limits for public health insurance eligibility may distort work incentives for low-earning workers. Since 1996, states may vary their parental Medicaid eligibility criteria independently of other assistance programs. The result is substantial variation across states and over time in the earnings thresholds to which workers must adhere to maintain eligibility. Utilizing this variation, I identify the effects of Medicaid earnings thresholds on labor force behavior of low-income single mothers, examining both static and dynamic patterns. I find some evidence that allocating government funds to increasing these thresholds could be used as a policy lever to help drive increased earnings among low-income women.
Fault Location Methods for Ungrounded Distribution Systems Using Local Measurements
Authors: Xiu Wanjing , Liao Yuan 
Published: August 2013

Abstract
This article presents novel fault location algorithms for ungrounded distribution systems. The proposed methods are capable of locating faults by using obtained voltage and current measurements at the local substation. Two types of fault location algorithms, using line to neutral and line to line measurements, are presented. The network structure and parameters are assumed to be known. The network structure needs to be updated based on information obtained from utility telemetry system. With the help of bus impedance matrix, local voltage changes due to the fault can be expressed as a function of fault currents. Since the bus impedance matrix contains information about fault location, superimposed voltages at local substation can be expressed as a function of fault location, through which fault location can be solved. Simulation studies have been carried out based on a sample distribution power system. From the evaluation study, it is evinced that very accurate fault location estimates are obtained from both types of methods.
Consensus Recovery from Intentional Attacks in Directed Nonlinear Multi-agent Systems
Authors: Shang Yilun 
Published: August 2013

Abstract
Resilience or recovery of multi-agent systems against attacks is believed to be one of the most important topics in control and management of complex systems. Previous studies have mainly focused on the random failure and intentional attack targeted on node degrees, whereas consensus recovery is much less investigated. In this paper, two kinds of targeted attacks are introduced and corresponding recovery strategies are proposed to address the consensus recovery of continuous-time nonlinear multi-agent systems under directed topologies against subsequent attacks. The cut-nodes and cut-edges are chosen as the targets of attack, and the multi-agent system becomes disconnected when they are deleted from the system. The neighbor nodes of the cut-node and end nodes of the cut-edge are used to recover the connectivity of the network. It is shown that our proposed strategies can significantly improve the convergence speed of reaching consensus of the resulting multi-agent systems. A cost function is also proposed to compare different recovery strategies.
Tri-integrable Couplings by Matrix Loop Algebras
Authors: Ma Wen-Xiu , Meng Jinghan , Zhang Huiqun 
Published: August 2013

Abstract
We create a class of non-semisimple matrix loop algebras, and use the associated zero curvature equations to construct tri-integrable couplings. An application is made for the AKNS equations as an illustrative example. Hamiltonian structures of the resulting tri-integrable couplings are furnished by the variational identities over the presented matrix loop algebras, which implies the commutativity of the sequences of symmetries and conserved functionals.
Limiting Early-Age Cracking in Concrete Bridge Decks
Authors: ElSafty Adel , Abdel-Mohti Ahmed , Jackson Mike , Lasa Ivan , Paredes Mario 
Published: August 2013

Abstract
Early-age bridge-deck cracking is a major problem affecting the durability of U.S. bridges. Many factors can cause early-age bridge-deck cracking including change in temperature, hydration, plastic shrinkage, autogenous shrinkage, and drying shrinkage. The presence of cracking may increase the effect of freeze and thaw cycles and may lead to corrosion of reinforcement, which may result in deterioration of the entire bridge. It is crucial to investigate the issue of early-age cracking in bridge decks to provide solutions to improve the safety of U.S. bridges. This research examines the use of different sealing materials to seal the developed cracks while the performance criteria can be achieved. An analytical study was performed to study the importance of major parameters that may affect the transverse deck cracking, such as concrete strength, shrinkage, thermal effect, load patterns, load magnitude, span length, number of spans, and continuity. A finite-element model was developed to investigate the factors affecting tensile stresses and crack tendency. Also, a tool was developed to predict the likelihood and initiation of early-age cracking in bridge decks. The outcomes of this study identify suitable sealant materials and identify a set of recommendations to limit the cracking problem and, hence, resulting in a longer service life to bridges.
Expansive Clay Suction Measurements Using Filter Paper and Polymer-Capacitance Sensor Methods
Authors: Lee Landris T. 
Published: August 2013

Abstract
Total suction values of undisturbed partially saturated expansive soil samples were synchronously measured using filter paper and miniature polymer-capacitance sensors. Soil suction-water content curves derived from enclosed headspace water vapor measurements were obtained for each method. Shrink-swell measurements were then correlated to the total suction values in order to demonstrate the applicability of either test method for estimating potential volume change.
Mechanical Properties of Frozen Soil
Authors: Zubeck Hannele , Yang Zhaohui 
Published: August 2013

Description
Thirteen peer-reviewed papers cover the latest information on: research needed in frozen soil related engineering and frozen soil standard development needs including thaw consolidation test, shear stress test, triaxial compression test, unfrozen water content test, segregation potential test, handling-transportation-storage of frozen samples for laboratory testing, and sample preparation for laboratory testing.
The papers are divided into four topics
A Whole-Genome DNA Marker Map for Cotton Based on the D-Genome Sequence of Gossypium raimondii L.
Authors: Wang Zining , Zhang Dong , Wang Xiyin , Tan Xu , Guo Hui , Paterson Andrew H 
Published: August 2013

Abstract
We constructed a very-high-density, whole-genome marker map (WGMM) for cotton by using 18,597 DNA markers corresponding to 48,958 loci that were aligned to both a consensus genetic map and a reference genome sequence. The WGMM has a density of one locus per 15.6 kb, or an average of 1.3 loci per gene. The WGMM was anchored by the use of colinear markers to a detailed genetic map, providing recombinational information. Mapped markers occurred at relatively greater physical densities in distal chromosomal regions and lower physical densities in the central regions, with all 1 Mb bins having at least nine markers. Hotspots for quantitative trait loci and resistance gene analog clusters were aligned to the map and DNA markers identified for targeting of these regions of high practical importance. Based on the cotton D genome reference sequence, the locations of chromosome structural rearrangements plotted on the map facilitate its translation to other Gossypium genome types. The WGMM is a versatile genetic map for marker assisted breeding, fine mapping and cloning of genes and quantitative trait loci, developing new genetic markers and maps, genome-wide association mapping, and genome evolution studies.
Insights into the Evolution of Cotton Diploids and Polyploids from Whole-Genome Re-sequencing
Authors: Page Justin T , Huynh Mark D , Liechty Zach S , Grupp Kara , Stelly David , Hulse Amanda M , Ashrafi Hamid , Van Deynze Allen , Wendel Jonathan F , Udall Joshua A 
Published: August 2013

Abstract
Understanding the composition, evolution, and function of the Gossypium hirsutum (cotton) genome is complicated by the joint presence of two genomes in its nucleus (AT and DT genomes). These two genomes were derived from progenitor A-genome and D-genome diploids involved in ancestral allopolyploidization. To better understand the allopolyploid genome, we re-sequenced the genomes of extant diploid relatives that contain the A1 (Gossypium herbaceum), A2 (Gossypium arboreum), or D5 (Gossypium raimondii) genomes. We conducted a comparative analysis using deep re-sequencing of multiple accessions of each diploid species and identified 24 million SNPs between the A-diploid and D-diploid genomes. These analyses facilitated the construction of a robust index of conserved SNPs between the A-genomes and D-genomes at all detected polymorphic loci. This index is widely applicable for read mapping efforts of other diploid and allopolyploid Gossypium accessions. Further analysis also revealed locations of putative duplications and deletions in the A-genome relative to the D-genome reference sequence. The approximately 25,400 deleted regions included more than 50% deletion of 978 genes, including many involved with starch synthesis. In the polyploid genome, we also detected 1,472 conversion events between homoeologous chromosomes, including events that overlapped 113 genes. Continued characterization of the Gossypium genomes will further enhance our ability to manipulate fiber and agronomic production of cotton.
Comparing Zinc Finger Nucleases and Transcription Activator-Like Effector Nucleases for Gene Targeting in Drosophila
Authors: Beumer Kelly J , Trautman Jonathan K , Christian Michelle , Dahlem Timothy J , Lake Cathleen M , Hawley R Scott , Grunwald David J , Voytas Daniel F , Carroll Dana 
Published: August 2013

AbstractZinc-finger nucleases have proven to be successful as reagents for targeted genome manipulation in Drosophila melanogaster and many other organisms. Their utility has been limited, however, by the significant failure rate of new designs, reflecting the complexity of DNA recognition by zinc fingers. Transcription activator-like effector (TALE) DNA-binding domains depend on a simple, one-module-to-one-base-pair recognition code, and they have been very productively incorporated into nucleases (TALENs) for genome engineering. In this report we describe the design of TALENs for a number of different genes in Drosophila, and we explore several parameters of TALEN design. The rate of success with TALENs was substantially greater than for zinc-finger nucleases , and the frequency of mutagenesis was comparable. Knockout mutations were isolated in several genes in which such alleles were not previously available. TALENs are an effective tool for targeted genome manipulation in Drosophila.