bluuebunny/crossref_metadata_2025_split huggingface dataset:
In-hospital treatment and outcomes of heart failure in specialist and non-specialist services: a retrospective cohort study in the elderly
Authors: Parmar Kishan R , Xiu Philip Y , Chowdhury Muhibbur R , Patel Ekta , Cohen Maurice 
Published: May 2015

BackgroundHeart failure is common in the elderly and is associated with high rates of hospitalisation, readmission and mortality. International guidelines however are not frequently implemented in this population.MethodsWe retrospectively studied the clinical profile, investigations, treatment on discharge, length of hospital stay, readmission rate and mortality in 261 patients, aged ≥75 years, with a discharge diagnosis of heart failure. Clinical frailty was estimated using the Canadian Study of Health and Aging clinical frailty scale.ResultsHypertension (64%), atrial fibrillation (50.6%) and ischaemic heart disease (46%) were common, and 75.6% of patients were clinically vulnerable or frail. 23.5% of admitters had an inpatient echocardiogram and 20% of patients had at least one readmission episode for heart failure. On discharge, 64.6% of admissions were treated with an ACE inhibitor or angiotensin II receptor antagonist, 49.3% with a β blocker and 28.7% with an aldosterone receptor antagonist (ARA). Patients discharged from cardiology wards were more likely to receive a β blocker (p<0.05) versus care of elderly (COE) wards and readmitters were more likely to receive an ARA (p<0.05) versus patients with a single admission. In total, 34 inpatient deaths were recorded (13%) and 80 deaths (30.7%) were recorded long-term (median follow-up 337 days). Long-term mortality was significantly lower in single admitters versus readmitters (p<0.0001) and in those managed on cardiology wards versus COE wards (p<0.05).ConclusionsCompared with patients hospitalised on geriatric wards, those admitted to cardiology units were discharged more frequently with recommended medications and had a lower long-term mortality.
Socioeconomic inequities in perceived health among patients with musculoskeletal disorders compared with other chronic disorders: results from a cross-sectional Dutch study
Authors: Putrik P , Ramiro S , Chorus A M , Keszei A P , Boonen A 
Published: May 2015

ObjectivesTo explore the impact of socioeconomic factors on physical and mental health of patients with musculoskeletal disorders (MSKDs) and compare it across patients with other disorders.MethodsA representative sample of the Dutch population (n=8904) completed a survey on sociodemographics, physician-diagnosed (co-) morbidities, and physical (physical component summary, PCS) and mental (mental component summary, MCS) subscales of SF-12 (outcome variables). Regression models were computed first in the total group of patients with MSKDs, with education, age, gender, origin and place of residence as independent variables, and, second, in individuals expected to have paid work, adding a variable on social status. Models were repeated for five other subgroups of chronic disorders (cardiovascular (CVD), diabetes, cancer, mental and respiratory) and for healthy individuals.ResultsMSKDs confirmed by a physician were reported by 1766 (20%) participants (mean age 59 years, 38% male), 547 (6%) respondents reported to have diabetes, 1855 (21%) CVD, 270 (3%) cancer, 526 (6%) mental disorders, 679 (8%) respiratory disorders and 4525 (51%) did not report any disease. In patients with MSKDs, (primary school vs university education (−5.3 (PCS) and −3.3 (MCS)) and having a state subsidy vs paid work (−5.3 (PCS) and −4.7 (MCS)) were consistently associated with worse physical and mental health. Gender was only relevant for PCS (female vs male −2.1). Comparable differences in health by education and social status were observed in the other diseases, except for cancer.ConclusionsEducation and social status in MSKD have the same strong and independent association with health as in other chronic diseases. These health gradients are unfair and partly avoidable, and require consorted attention and action in and outside healthcare.
Longer durations of antitumour necrosis factor treatment are associated with reduced risk of cardiovascular events in patients with rheumatoid arthritis
Authors: Nurmohamed Michael , Bao Yanjun , Signorovitch James , Trahey Alex , Mulani Parvez , Furst Daniel E 
Published: May 2015

ObjectiveTo assess the effects of treatment with antitumour necrosis factor (TNF) agents, methotrexate, or other non-biological disease-modifying antirheumatic drugs (DMARDs) on cardiovascular event risks among patients with rheumatoid arthritis (RA).MethodsWe conducted a retrospective study using data from the MarketScan claims database. Patients with RA with ≥1 prescription for an index drug were included. Each patient's use of an index drug was calculated cumulatively as a time-varying exposure. The incidence of cardiovascular events among patients with RA was determined. Associations between drug exposures and occurrence of cardiovascular events were assessed with Cox proportional hazards models.ResultsOf 113 677 patients identified, 35.8%, 41.1% and 23.1% received anti-TNF agents, methotrexate and other DMARDs, respectively. Patients were treated for an average of 7.6 months; 2138 patients (1.9%) had a cardiovascular event following their index prescription. Each additional 6 months of anti-TNF therapy use versus non-use reduced the risk (HR; 95% CI) for any cardiovascular event by 12% (0.88; 0.81 to 0.95, p=0.002). Anti-TNF therapy was associated with a 13% and 12% reduction in cardiovascular events in patients aged ≥50 years (0.87; 0.80 to 0.95, p=0.002) and in those without prior methotrexate use (0.88; 0.78 to 0.99, p=0.04), respectively. Cumulative use of 1, 2 or 3 years of anti-TNF therapy versus non-use is expected to reduce cardiovascular event risks by 21%, 38% and 51%, respectively.ConclusionsAnti-TNF therapy was associated with a significantly lower risk of cardiovascular events among patients with RA, older patients with RA and patients without prior exposure to methotrexate.
Metamorphic and age constraints on crustal reworking in the western H.U. Sverdrupfjella: implications for the evolution of western Dronning Maud Land, Antarctica
Authors: Grosch Eugene G. , Frimmel Hartwig E. , Abu-Alam Tamer , Košler Jan 
Published: May 2015

A petrological and metamorphic comparison of Mesoproterozoic metabasic rocks was conducted on the eastern margin of the Archaean Kaapvaal–Grunehogna Craton and the adjacent westernmost Maud Belt (western H.U. Sverdrupfjella), across a major structural discontinuity known as the Pencksökket–Jutulstraumen Discontinuity. Thermodynamic phase diagram modelling of the low- and high-grade metabasaltic assemblages on either side of the discontinuity revealed a difference in peak metamorphic conditions from
T
= 340 ± 25 to 700 ± 30°C and
P
= 0.29 ± 0.08 to 0.90 ± 0.10 GPa over an extrapolated orthogonal distance of 32 km across the strike of the discontinuity. Laser ablation inductively coupled plasma mass spectrometry U–Pb dating of titanite in a hornblende–plagioclase–quartz corona around garnet yielded a late Pan-African age of 491 ± 27 Ma for high-grade metamorphism in the western H.U. Sverdrupfjella of the Maud Belt. The new petrological and geochronological constraints indicate that peak upper amphibolite-facies conditions were achieved in the western H.U. Sverdrupfjella at
c
. 500 Ma; namely,
c
. 70–80 Ma after peak eclogite–high-pressure granulite-facies metamorphism in the eastern H.U. Sverdrupjella. The U–Pb age data argue against previous models that invoke only late Mesoproterozoic (
c
. 1060–1030 Ma) granulite-facies metamorphism in the western H.U. Sverdrupfjella and Kaapvaal–Grunehogna Craton margin, and support the concept of a major diachronous Pan-African orogenic episode. A new geodynamic model is presented for western Dronning Maud Land, involving earliest Pan-African eclogite–high-pressure granulite- and upper amphibolite-facies metamorphism in a separate eastern H.U. Sverdrupjella terrane between
c
. 565 and 540 Ma, followed by later diachronous tectonic accretion of the eastern H.U. Sverdrupjella arc segment onto the western H.U. Sverdrupfjella crustal segment (including the easternmost Kaapvaal–Grunehogna Craton margin) that involved only upper amphibolite-facies metamorphism at
c
. 500 Ma. The new petrological data indicate that the inferred sub-glacial boundary (Pencksökket–Jutulstraumen Discontinuity) between the Kaapvaal–Grunehogna Craton and the western H.U. Sverdrupfjella region represents a major cratonic Pan-African thrust, which was subsequently reactivated by normal faulting during Gondwana break-up.

Supplementary materials:

Analytical details, representative mineral compositions, and geothermometry and geobarometry results are available at
http://www.geolsoc.org.uk/SUP18832
.
The temporal record of magmatism at Cerro Uturuncu, Bolivian Altiplano
Authors: Muir D. D. , Barfod D. N. , Blundy J. D. , Rust A. C. , Sparks R. S. J. , Clarke K. M. 
Published: May 2015

Abstract

Twenty-six new
40
Ar/
39
Ar plateau ages for 23 lavas and domes from the Uturuncu volcano in the Altiplano of SW Bolivia reveal a protracted eruptive history from 1050±5 to 250±5 ka. Eruptions have been exclusively effusive, producing some 50 km
3
of high-K dacites and silicic andesites. Bimodal mineral compositions, complex mineral textures, the presence of andesitic magmatic enclaves within dacites and linear chemical trends on binary element plots all indicate that magma mixing is an important petrogenetic process at Uturuncu. Post-458 ka, distinct high and low MgO–Cr magmas are resolved. These magmas erupt during similar times, suggesting that eruptions are tapping different parts of the magma system, albeit from the same vent system. Volcanic and petrological features are consistent with the existence of a vertically extensive magma mush column beneath Uturuncu, and calculated buoyancy forces are sufficient to drive effusive eruptions. Eruptive activity is episodic, with six eruptive periods separated by hiatuses of >50 kyr. Cumulative volume curves demonstrate that the majority of the edifice formed between 595 and 505 ka. The episodicity of eruptions is most likely to be related to fluctuations in the magma supply to the underlying Altiplano–Puno Magma Body.

Supplementary material:

Detailed
40
Ar/
39
Ar data, and lava flow and dome areas, volumes and stratigraphic ages where absolute ages are lacking are available at
www.geolsoc.org.uk/SUP18815
Palaeomagnetic and geochronological data from Late Mesoproterozoic redbed sedimentary rocks on the western margin of Kalahari craton
Authors: Kasbohm Jennifer , Evans David A. D. , Panzik Joseph E. , Hofmann Mandy , Linnemann Ulf 
Published: May 2015

Abstract

Redbeds of the Aubures Formation constitute the uppermost stratigraphic unit in the Mesoproterozoic Sinclair succession of southern Namibia. Aubures palaeomagnetic remanence vectors, held almost exclusively by hematite, document at least one geomagnetic polarity reversal in the stratigraphy, a positive intraformational conglomerate test indicating primary magnetization and greatest concentration of characteristic directions at 50–60% untilting, indicating that deformation was coincident with sedimentation. The new Aubures palaeomagnetic pole, at 56.4°N and 018.0°E with
A
95
=11.3°, is located on the apparent polar wander path of the Kalahari craton, between poles of the 1110 Ma Umkondo igneous event and the
c.
1090 Ma Kalkpunt redbeds of the Koras Group near Upington, South Africa. This distinctive concordance suggests that Aubures sediments have an age of approximately 1100 Ma, that the Sinclair region was probably part of Kalahari at that time and that the Aubures and Kalkpunt redbeds are broadly correlative. New laser-ablation inductively coupled plasma mass spectrometry detrital zircon results from the Aubures Formation, including a youngest age component (1108±9 Ma) that is coincident with the Kalahari-wide Umkondo large igneous province, conform to this interpretation. Palaeomagnetism and geochronology of the Sinclair succession can provide kinematic constraints on the tectonic evolution of Kalahari as it approached other cratons in the growing Rodinia supercontinent.
Thermal monitoring of volcanic effusive activity: the uncertainties and outlier detection
Authors: Zakšek Klemen , Pick Leonie , Shirzaei Manoochehr , Hort Matthias 
Published: May 2015

Abstract

Thermal observations of volcanic activity when the volcano is partially covered by clouds or observed under a wide-scan angle are often removed from further analyses. In the event of a volcanic crisis, such a reduced set of data is not adequate. Even when the observation conditions are favourable, the full observation set is still required to provide decision-makers with quality information about the data. Automatic quality estimation and outlier detection was not estimated in the past. We propose to analytically define the uncertainty for individual observations based on the measurement circumstances. To additionally reduce the temporal noise of the radiant power (
RP
) time series we apply a Kalman Filter (KF). The KF is able to recursively analyse an unevenly sampled time series. Based on some proposed rules, it can also detect outliers. We apply the proposed methodology to the 2008–09 Etna eruption monitored by MODIS (Moderate Resolution Imaging Spectroradiometer). The analysis of the results shows that the topography has a greater influence on
RP
than previously considered.
Does Stroke Contribute to Racial Differences in Cognitive Decline?
Authors: Levine Deborah A. , Kabeto Mohammed , Langa Kenneth M. , Lisabeth Lynda D. , Rogers Mary A.M. , Galecki Andrzej T. 
Published: May 2015

Background and Purpose—
It is unknown whether blacks’ elevated risk of dementia is because of racial differences in acute stroke, the impact of stroke on cognitive health, or other factors. We investigated whether racial differences in cognitive decline are explained by differences in the frequency or impact of incident stroke between blacks and whites, controlling for baseline cognition.

Methods—
Among 4908 black and white participants aged ≥65 years free of stroke and cognitive impairment in the nationally representative Health and Retirement Study with linked Medicare data (1998–2010), we examined longitudinal changes in global cognition (modified version of the Telephone Interview for Cognitive Status) by race, before and after adjusting for time-dependent incident stroke followed by a race-by-incident stroke interaction term, using linear mixed-effects models that included fixed effects of participant demographics, clinical factors, and cognition, and random effects for intercept and slope for time.

Results—

We identified 34 of 453 (7.5%) blacks and 300 of 4455 (6.7%) whites with incident stroke over a mean (SD) of 4.1 (1.9) years of follow-up (
P
=0.53). Blacks had greater cognitive decline than whites (adjusted difference in modified version of the Telephone Interview for Cognitive Status score, 1.47 points; 95% confidence interval, 1.21 to 1.73 points). With further adjustment for cumulative incidence of stroke, the black–white difference in cognitive decline persisted. Incident stroke was associated with a decrease in global cognition (1.21 points;
P
<0.001) corresponding to ≈7.9 years of cognitive aging. The effect of incident stroke on cognition did not statistically differ by race (
P
=0.52).

Conclusions—
In this population-based cohort of older adults, incident stroke did not explain black–white differences in cognitive decline or impact cognition differently by race.
Stroke Is the Leading Cause of Death in Rural Gadchiroli, India
Authors: Kalkonde Yogeshwar V. , Deshmukh Mahesh D. , Sahane Vikram , Puthran Jyoti , Kakarmath Sujay , Agavane Vaibhav , Bang Abhay 
Published: May 2015

Background and Purpose—
Stroke is an important cause of death and disability worldwide. However, information on stroke deaths in rural India is scarce. To measure the mortality burden of stroke, we conducted a community-based study in a rural area of Gadchiroli, one of the most backward districts of India.

Methods—
We prospectively collected information on all deaths from April 2011 to March 2013 and assigned causes of death using a well-validated verbal autopsy tool in a rural population of 94 154 individuals residing in 86 villages. Two trained physicians independently assigned the cause of death, and the disagreements were resolved by a third physician.

Results—
Of 1599 deaths during the study period, 229 (14.3%) deaths were caused by stroke. Stroke was the most frequent cause of death. For those who died because of stroke, the mean age was 67.47±11.8 years and 48.47% were women. Crude stroke mortality rate was 121.6 (95% confidence interval, 106.4–138.4), and age-standardized stroke mortality rate was 191.9 (95% confidence interval, 165.8–221.1) per 100 000 population. Of total stroke deaths, 87.3% stroke deaths occurred at home and 46.3% occurred within the first month from the onset of symptoms.

Conclusions—
Stroke is the leading cause of death and accounted for 1 in 7 deaths in this rural community in Gadchiroli. There was high early mortality, and the mortality rate because of stroke was higher than that reported from previous studies from India. Stroke is emerging as a public health priority in rural India.
On the Leading Patterns of Northern Hemisphere Sea Level Pressure Variability*
Authors: Smoliak Brian V. , Wallace John M. 
Published: May 2015

Abstract
The leading patterns of variability of the monthly mean Northern Hemisphere (NH) sea level pressure (SLP) field, as derived from empirical orthogonal teleconnection (EOT) analysis of a 93-yr (1920–2012) record of NOAA–CIRES 20th Century Reanalyses, are presented and discussed, with emphasis on wintertime patterns. The analysis yields nine or more highly reproducible wintertime hemispheric EOTs, the first six of which closely resemble EOF1 or EOF2 in their respective sectors of the hemisphere. Collectively, the first nine wintertime patterns account for 70% of the variance of NH SLP, 40% of the variance of NH surface air temperature (SAT), and 52% of the variance of the time series of NH-mean SAT poleward of 20°N. Wintertime EOT1 corresponds to the NH annular mode (NAM) and EOT2 corresponds to the SLP expression of the Pacific–North America pattern. The remaining wintertime EOT patterns are monopoles arranged like the links of a chain wrapped around the primary center of action of the annular mode. The NH summertime and Southern Hemisphere patterns are arranged in a similar manner. The continental NH wintertime patterns exhibit strong temperature anomalies of reversed polarity to their respective SLP monopoles. The interannual variability of wintertime EOTs 3–9 and summertime EOTs 2–9 is dominated by sampling fluctuations. Over the 93-yr record, the more prominent continental wintertime patterns exhibit weak trends toward falling SLP and rising SAT, particularly over Russia and Alaska. The interpretation of shorter-term trends is more ambiguous.
Mesoscale Convection and Bimodal Cyclogenesis over the Bay of Bengal
Authors: Akter Nasreen 
Published: May 2015

AbstractMesoscale convective systems (MCSs) are an essential component of cyclogenesis, and their structure and characteristics determine the intensity and severity of associated cyclones. Case studies were performed by simulating tropical cyclones that formed during the pre- and postmonsoon periods in 2007 and 2010 over the Bay of Bengal (BoB). The pre- (post) monsoon environment was characterized by the coupling of northwesterly (southwesterly) wind to the early advance southwesterly (northeasterly) monsoonal wind in the BoB. The surges of low-level warm southwesterlies with clockwise-rotating vertical shear in the premonsoon period and moderately cool northeasterlies with anticlockwise-rotating vertical shear in the postmonsoon period transported moisture and triggered MCSs within preexisting disturbances near the monsoon trough over the BoB. Mature MCSs associated with bimodal cyclone formations were quasi linear, and they featured leading-edge deep convection and a trailing stratiform precipitation region, which was very narrow in the postmonsoon cases.In the premonsoon cases, the MCSs became severe bow echoes when intense and moist southwesterlies were imposed along the dryline convergence zone in the northern and northwestern BoB. However, the development formed a nonsevere and nonorganized linear system when the convergence zone was farther south of the dryline. In the postmonsoon cases, cyclogenesis was favored by squall-line MCSs with a north–south orientation over the BoB. All convective systems moved quickly, persisted for a long time, and contained suitable environments for developing low-level cyclonic mesovortices at their leading edges, which played an additional role in forming mesoscale convective vortices during cyclogenesis in the BoB.
Evaluation of Nonhydrostatic Simulations of Northeast Pacific Atmospheric Rivers and Comparison to in Situ Observations
Authors: Swain Daniel L. , Lebassi-Habtezion Bereket , Diffenbaugh Noah S. 
Published: May 2015

Abstract
Atmospheric rivers are long, narrow bands of concentrated atmospheric water vapor transport that provide an important atmospheric linkage between the subtropics and the midlatitudes, facilitating over 90% of meridional water vapor flux and often resulting in extreme precipitation events in regions of enhanced coastal orography. In this investigation, the authors conduct continuous (3 month), large-domain (3600 km × 3200 km), high-resolution (4 km), nonhydrostatic simulations using the Weather Research and Forecasting (WRF) Model and compare the observations to previously reported dropsonde observations from the California Land-Falling Jets Experiment (CALJET) and the Pacific Land-Falling Jets Experiment (PACJET) in order to address an existing gap in knowledge regarding the ability of atmospheric models to simulate the finescale vertical and horizontal structure of atmospheric rivers. The WRF simulations reproduce key structural and thermodynamic characteristics of atmospheric rivers—including well-defined corridors of strong water vapor transport, moist-neutral stability in the lower troposphere, and strong low-level jet/water vapor transport maxima near ~1 km MSL. While WRF does generally capture the extreme values of instantaneous vertically integrated water transport—a defining feature of real-world atmospheric rivers—constituent variables exhibit biases relative to observations, including −11.2% for integrated vapor transport, +5.9% for integrated water vapor, and −17.7% for 1 km MSL wind speed. Findings suggest that high-resolution nonhydrostatic atmospheric simulations are an appropriate tool for investigating atmospheric rivers in contexts where finescale spatial structure and realistic water vapor transport maxima are important.