bluuebunny/crossref_metadata_2025_split huggingface dataset:
Classification of Coronary Artery Disease Using Radial Artery Pulse Wave Analysis via Machine Learning
Authors: Lyu Yi , Wu Hai-Mei , Yan Hai-Xia , Guo Rui , Xiong Yu-Jie , Chen Rui , Huang Wen-Yue , Hong Jing , Lyu Rong , Wang Yi-Qin , Xu Jin 
Published: August 2024

Abstract

Background
Coronary artery disease (CAD) is a major global cardiovascular health threat and the leading cause of death in many countries. The disease has a significant impact in China, where it has become the leading cause of death. There is an urgent need to develop non-invasive, rapid, cost-effective, and reliable techniques for the early detection of CAD using machine learning (ML).
Methods
608 participants were divided into three groups: healthy, hypertensive, and CAD. The raw data of pulse wave from those participants was collected. The data were de-noised, normalized, and analyzed using several applications. Seven ML classifiers were used to model the processed data, including Decision Tree (DT), Random Forest (RF), Gradient Boosting Decision Tree (GBDT), Extra Trees (ET), Extreme Gradient Boosting (XGBoost), Light Gradient Boosting (LightGBM), and Unbiased Boosting with Categorical Features (CatBoost).
Results
The Extra Trees classifier demonstrated the best classification performance. After tunning, the average results were 86.6% accuracy, 91.36% AUC, 86.6% recall, 87.27% precision, 86.58% F1 score, 0.7984 kappa coefficient, and 0.8018 MCC. The macro-average AUC of validation result for independent test set is 94%. The top 10 feature importances of ET model are w/t1, t3/tmax, tmax, t3/t1, As, hf/3, tf/3/tmax, tf/5, w and tf/3/t1.
Conclusion
Radial artery pulse wave can be used to identify healthy, hypertensive and CAD participants by using Extra Trees Classifier. This method provides a potential pathway to recognize CAD patients by using a simple, non-invasive, and cost-effective technique.
First Reported Advanced Pancreatic Cancer With Hyperprogression Treated With PD-1 Blockade combined with chemotherapy: A Case Report And Literature Review
Authors: Wang Ya-Zhou , Peng Mao-Zhen , Xu Yao-Lin , Ying Ying , Tang Lin-Hui , Xu Hua-Xiang , He Jun-Yi , Liu Liang , Wang Wen-Quan 
Published: August 2024

Abstract

Immunotherapy has demonstrated significant potential in the treatment of cancer and is now recommended as a first-line therapy for small cell lung cancer and melanoma. However, a novel response pattern has been delineated, characterized by an abrupt acceleration of tumor growth subsequent to immunotherapy. These unforeseen adverse events are denoted as hyper progressive disease (HPD). The occurrence of HPD is observed not only in patients undergoing immunotherapy but also in those receiving chemotherapy, albeit with a comparatively lower frequency within the chemotherapy cohort. In the management of metastatic pancreatic cancer, the combination of chemotherapy and immunotherapy presents a promising therapeutic approach; however, there remains an unresolved question regarding the association between this combination therapy and HPD. Herein, we present a case report of a 59-year-old patient with metastatic pancreatic cancer exhibiting high PD-1/PD-L1 expression identified through next-generation sequencing data, suggesting the potential efficacy of PD-1 immunotherapy. Therefore, we administered serplulimab (a novel anti-PD-1 antibody) in combination with gemcitabine/nab-paclitaxel. The patient initially exhibited a favorable response to the combination therapy of immunotherapy and chemotherapy; however, subsequent tumor enlargement and a significant deterioration in physical condition occurred. To our knowledge, this is the first reported case of HPD in pancreatic cancer with multiple metastases treated using combination therapy. Based on this case, we propose a potential association between combination therapy and HPD in pancreatic cancer.
Foliar application of AgNPs synthesized with different methods modifies the nutritional properties of potato tubers
Authors: Tokarz Krzysztof M. , Mazur Tomasz , Hanula Monika , Makowski Wojciech , Zawal Piotr , Jędrzejczyk Roman J , Szacilowski Konrad , Mazur Stanisław , Tokarz Barbara 
Published: August 2024

Abstract

The effectiveness of silver nanoparticles, addressing different methods of their synthesis, with regard both to accumulation of Ag ions and the nutritional properties of potato tubers in field potato cultivation was the aim of presented study. Potato plants were sprayed with different concentration of Ag nanoparticles (0.1, 1.0 and 10 mg·dm− 3) synthesized with incorporation with sodium dodecyl sulphate (SDS) and sodium citrate as capping agent. The lowest amounts of silver ions were transported to the tubers after spraying with AgNPs synthesized with SDS, rather than with citrate. Nevertheless silver ions accumulation in tubers was negligible. SDS method of synthesis was more favourable in terms of nutritional properties of potato tubers. The highest tested concentration of AgNPs_SDS had a favourable effect on a variety of macro- and micronutrients, ascorbic acid and soluble sugars. In turn, lower concentrations of AgNPs_SDS increased the content of phenolic compounds and free radical scavenging efficiency of tubers.
The Impact of Connectivity and Software in Ethereum Validator Performance
Authors: Cortes-Goicoechea Mikel , Mohandas-Daryanani Tarun , Muñoz-Tapia Jose Luis , Bautista-Gomez Leonardo 
Published: August 2024

Abstract

Modern public blockchains like Ethereum rely on p2p networks to run distributed and censorship-resistant applications. With its wide adoption, it operates as a highly critical public ledger. On its transition to become more scalable and sustainable, shifting to PoS without sacrificing the security and resilience of PoW, Ethereum offers a range of consensus client implementations to participate in the network. In this paper, we present a methodology to measure the performance of the consensus clients based on the latency to receive messages from the p2p network. The paper includes a study that identifies the incentives and limitations that the network experiences, presenting insights about the latency impact derived from running the different consensus implementations at different locations.Our study highlights the need for a holistic approach to node deployment, where hardware, software, and geographic factors have to be carefully considered. Properly dimensioned hardware is essential to mitigate latency-related performance issues and ensure the reliable operation of beacon nodes, especially in geographically distant locations.
Rare taxa in the rhizosphere primarily influence nitrogen dynamics in plantations in northeastern China, with minimal impact on carbon and phosphorus
Authors: Pan Li , Wang Xiuwei 
Published: August 2024

Abstract

Aims
Rhizosphere effects refer to the alterations in soil properties resulting from the presence of plant roots. This study assessed the influence of rhizosphere microbial communities on the rhizosphere effects of carbon, nitrogen and phosphorus content.
Methods
we examined the rhizosphere effects of carbon, nitrogen and phosphorus in plantation forests of Acer saccharum (Ace), Larix gmelinii (Lar), Pinus sylvestris var. mongolica (Pin) and Populus sp. (Pin). We studied root functional traits and rhizosphere microbial communities and categorized rhizosphere microbes into two sub-communities, rare and abundant taxa, based on their relative abundance. Furthermore, we analyzed the chemical properties of rhizosphere and bulk soils and quantified the rhizosphere effects in the study areas.
Results
The results revealed that in Pop trees, the rhizosphere effects of total nitrogen and alkali-hydrolyzable nitrogen were significantly higher compared to other tree species. Abundant taxa assembly was dominated by deterministic processes, whereas rare taxa were more influenced by stochastic processes. The rhizosphere rare taxa exhibited a stronger correlation with root functional traits in comparison to the abundant taxa. Both the Random Forest Model and Partial Least Squares Path Model suggested that rhizosphere rare taxa played a crucial role in the rhizosphere effect of nitrogen. The rhizosphere effects of carbon and phosphorus could not be accounted for by the rhizosphere microbial community properties.
Conclusion
These results collectively suggest that plant roots may regulate the composition of the rhizosphere microbial sub-community to meet their nitrogen requirements, underscoring the importance of rare rhizosphere taxa in plant nutrient uptake.
Transcriptomic Analysis of Primary Breast Cancer Utilizing Gene Expression Datasets from Middle-aged Caucasian Women
Authors: Nayarisseri Anuraj , Ghosh Dipannita , Bandaru Srinivas , Chopra Ishita , chaudhary Rinku , Bhati Durvi , Kumar Abhishek , Dey Taniya , Bhrdwaj Anushka , Khan Arshiya , Sharma Khushboo , Kaur Manmeet , Panwar Umesh , Singh Sanjeev Kumar 
Published: August 2024

Abstract

Breast cancer due to its genetic and clinical diversity across various subtypes often presents overlapping molecular profiles. Despite evolving classification methods, it still poses challenges for accurate prognosis. The present study addresses this challenge by identifying genes associated with each clinical subtype through a comprehensive differential expression analysis. As a representative example of breast cancer, the expression dataset (SRA Project: SRP375823) was sourced from middle-aged Caucasian/European women. First, samples were categorized according to histological types, stratified into Luminal-A, -B, and HER2 enriched tumours, as well as based on EMT properties (presence or absence of circulating tumour cells (CTCs)) and p53 mutation status (presence or absence of P53 mutation). The entire differential expression analysis was conducted utilizing GATK and Tuxedo II pipelines, followed by functional enrichment analysis. Upon comparison with healthy controls, genes like mTOR, BARD, MYH10, APC exhibited significant associations with breast cancer. Within immunohistological subtypes, all the primary tumours regardless of immunohistological subtypes exhibited significant upregulation in gonadotrophin-releasing hormone (GnRH) pathways. Further, upon differential gene expression across tumours within p53 mutation statuses, HSPA1A (chaperone Hsp70) showed significantly lower expression in wild p53-negative (p53-) tumours compared to mutated p53-positive (p53+) tumours.In examining the differential expression in tumours across EMT characteristics, in CTC-positive (CTC+) tumours, various viral oncogenes like Epstein-Barr Virus, hepatitis B, and Kaposi-Sarcoma Associated Herpes Virus were upregulated. Overall present finding strives to identify unique molecular signatures for each breast cancer subtype/class providing a primary insight into identifying potential prognostic markers, particularly within the Caucasian demographic.
Pressure reduction and suction characteristics of the new digital single use Flexible Ureteroscope with Suction: An In-Vitro Experimental Study
Authors: Martínez Begoña Ballesta , Dragos Laurian , Tatanis Vasileios , Somani Bhaskar , Martinez Pedro Campillo , Angerri Oriol , Peteinaris Angelis , Tsaturyan Arman , Kanashiro Andres , Valverde Marina Garcés , Serrano Manuel Christian Garcia , Vivo Francisco Javiert Lopez , Fumero Sergio , Liatsikos Evangelos , Kallidonis Panagiotis 
Published: August 2024

Abstract

Purpose
To assess the time taken by the single use 7.5Fr suction flexible ureteroscope to reduce pressure under 40 mm Hg and to characterize the behavior of stones, fragments and dust during suction activation
Methods
An in vitro setting was developed for this experiment. A saline-filled globe, with the 7.5Fr single use suction flexible ureteroscope, PU3033AH (ZhuHai Pusen Medical Technology Co, Ltd, Guangdon, China), an automatic irrigation pump and a pressure monitoring set were used at four modalities; i) continuous suction, no irrigation inflow; ii) continuous suction, irrigation inflow on; iii) one-second rate intermittent suction, irrigation inflow on, and iv) half-second rate intermittent suction, irrigation inflow on. The behavior of calcium oxalate stones from 0.5 to 5 mm when being aspirated via the ureteroscope into a plastic container filled with saline was recorded.
Results
Suction with the PU3033AH worked properly with the inflow irritation on. The fastest strategy to lower the pressure was by continuously pressing the suction button with the irrigation inflow on. Overall, the median time to reach 40 mg was roughly 3.5 seconds. The PU3033AH could aspirate 0.5 mm stones. The suction mode on a continuous pattern allowed relocation of stones ranging from 1 to 5 mm on an experimental setup with no obstacles.
Conclusion
The PU3033AH was efficient in lowering pressure in a closed cavity mimicking the renal pelvis. Likewise, stone fragments under one millimeter were aspirated by the device whereas stones from one to five mm could be displaced when activating suction in continuous mode on an experimental setup with no obstacles.
A macro-model of masonry infilled RC frames with horizontal slip layers
Authors: su qiwang , Liu Ruihan , Xu Chaoxi , Hu Xinran 
Published: August 2024

Abstract

As a new type of non-structural component, the masonry infill with horizontal slip layer can change its failure mode from diagonal strut failure to slip failure during an earthquake and effectively reduce its damage. Although experimental methods and microscopic model analysis accurately capture the influence of the mechanical properties of the infill wall with horizontal slip layer on the reinforced concrete frame, they are often uneconomical and inefficient. In this paper, the mechanical properties of the infilled wall of the frame with horizontal slip layer were investigated based on the experiment and micro-model finite analysis, and the interaction relationship and failure mechanism between the infill wall with horizontal slip layer and the frame were discussed. A macro modelling method with equivalent member by geometrically dividing the masonry unit and springs was proposed. In comparison with the experimental results, the correctness of the macro model is verified to adequately simulate the mechanical behaviour of the masonry infilled reinforced concrete frame with horizontal layers. Finally, DIANA finite element software is employed to establish a bare reinforced concrete frame and a reinforced concrete frame infilled by masonry with horizontal slip layers, modal analysis and response spectrum analysis were carried out and the differences in analysis results were compared. The results showed that the infills increase the lateral stiffness of the frame structure, and reduce natural vibration period and the stress difference in longitudinal steel bars in the column of the frame with horizontal slip layers.
Designing a selective medium for primary isolation of H. pylori from gastric biopsy
Authors: hosseinali Zahra , Shahmari Fatemeh , Javanbakhat Parisa , Nemati Rasool , Yazdanbod Abbas , Teimourpour Roghayeh 
Published: August 2024

Abstract

H.pylori is a gram negative and spiral bacterium that transmitted among humans through oral-oral or oral fecal routs. Past studies have proven the role of this bacterium in causing stomach cancer. This is very fastidious and its recovery require very expensive and enriched medium. The present study aimed to introduce an improved, selective and cost effective medium with cheap and available ingredients without need of microaerophilic producer device.
Performance-Constrained Multi-Objective Optimization of Antennas for Miniaturization Design
Authors: Yang Qi , Wang Hongqiang , Peng Xin 
Published: August 2024

Abstract

The miniaturization of antennas is crucial as it improves the integration of wireless communication system. In order to achieve miniaturization of antennas, a performance-constrained multi-objective optimization method (PCMOM) considering the size and return loss is proposed. In the PCMOM method, a topology optimization strategy based on a multi-port network model is introduced, enabling the formation of antennas with various topological structures. Furthermore, we integrate the constraint of return loss performance into the non-dominated sorting genetic algorithm II (NSGA-II), eliminating solutions that do not meet performance requirements. Three patch antennas are designed using the PCMOM method and two of them are fabricated. Experimental results demonstrate that the proposed PCMOM method can effectively address the complex trade-off issues in antenna miniaturization design.
Seroprevalence and risk factors of Chlamydia abortus infection in Tibetan sheep in Qinghai province, China
Authors: Lei Fan , Yu Jiali , Niu Yaqian , Ba Te , Liang Lin 
Published: August 2024

Abstract

Background Chlamydia abortus
(C. abortus) is Gram-negative, intracellular bacterium, causing ovine enzootic abortion (OEA). No data about C. abortus infection are available in Tibetan sheep in Qinghai, China.
Result
A total of 1043 Tibetan sheep serum samples were collected from 8 Tibetan sheep flocks in Qinghai, China, then were detected for specific antibodies against C. abortus using a commercial ELISA Kit. The results showed that the overall seroprevalence of C. abortus in Tibetan sheep was 153/1043 (14.7%, 95% confidence interval [CI] 12.5–16.8). The prevalence in female and male Tibetan sheep was 58/421 (13.8%, 95% CI 10.5 ~ 17.1) and 95/622 (15.3%, 95% CI 18.6 ~ 26.6), respectively with no significant difference (P > 0.05). The seroprevalence of antibodies to C. abortus in Tibetan sheep ranged from 10.0 to 21.7% among the eight different areas, and the difference was also without statistical significance [1]. The prevalence among different age groups ranged from 14.0 to 16.5%, with a higher prevalence among 1 to 1.5 years age category.
Conclusion
The results demonstrate the presence of C. abortus infection in Tibetan sheep in Qinghai and its potential impact on public health and the local Tibetan economy. To our knowledge, this is the first seroprevalence survey of C. abortus in Tibetan sheep in Qinghai, China.
Land degradation and food security nexus in Sub Saharan Africa
Authors: Ceesay Ebrima K. , Valere Kadio , Gitteh Alasana , Ndiaye Mohamed Ben Omar , Cham Amadou 
Published: August 2024

Abstract

Introduction: This article explores the relationship between land degradation and food security in Sub-Saharan African countries, shedding light on the critical issues faced in the region. Land degradation, caused by factors such as poor rainfall, deforestation, erosion, and other major causes, significantly impacts the fertility of the soil, leading to food security challenges. Understanding the impact of desertification, poor rainfall, drought, and extreme climate change in Africa is crucial to addressing food security problems in the region.
Method: The study utilizes data from the World Development Indicators and employs instrumental variable estimation (IV), panel OLS and pooled OLS methods to analyze the relationship between food production (as a proxy for food security) and various independent variables, including arable land area, fertilizer consumption, agricultural irrigated land area, and average precipitation depth.
Results: The findings reveal three different types of regression analyses. The first analysis was to Instrumental variable estimation (IV). When we used rainfall and GHG as an instrument for land productivity, proxy land degradation, we found that land productivity and cereal yields increases food productions, proxy food security. The second analysis, a random-effects Generalizing least square regression, indicates that fertilizer consumption and average precipitation depth are significant predictors of food production. However, arable land area and agricultural irrigated land area do not significantly impact food production. Interestingly, agricultural irrigated land shows a positive effect on food security in Sub-Saharan African countries, while arable land (as a proxy for land degradation) has a negative impact on food security in the region. The third analysis, a multiple linear regression, supports the results of the Generalizing least square regression, demonstrating that fertilizer consumption and average precipitation depth are significant predictors of food production. However, arable land area do not significantly influence food production. Remarkably, agricultural irrigated land is found to be a positive predictor of food production and serves as a proxy for food security.
Discussion: In conclusion, this study highlights the detrimental impact of land degradation on food security in Sub-Saharan African countries. It emphasizes the significance of factors such as fertilizer consumption, land productivity-proxy land degradation, cereal yields, Greenhouse gas emission, average precipitation depth, and the role of agricultural irrigated land in addressing food security challenges in the region.
Comparative evaluation of various DNA extraction methods and analysis of DNA degradation levels in commercially marketed Chestnut Rose Juices and Beverages
Authors: Ren Yongchao , Ma Yunlong , Li Yanqi , Song Yun , Zhao WeiWei , Huang Xuncai , Yu Danmin , Li Jian , Xu Zuogang , Zhao Wenjun 
Published: August 2024

Abstract

Background
Food safety is a significant global study subject that is strongly intertwined with human life and well-being. The utilization of DNA-based methods for species identification is a valuable instrument in the field of food inspection and regulation. It is particularly significant for traceability purposes, as it enables the monitoring of a specific item at every level of the food chain regulation. However, obtaining amplifiable genomic DNA in this process is a significant obstacle in gene studies. To date, there is a lack of literature on DNA extraction from processed juice or beverages, and no data exist on simultaneous comparisons of various extraction processes. This study aimed to optimize, assess, and compare four distinct DNA extraction methods for isolating DNA from highly processed Chestnut rose juices or beverages. Furthermore, we also conducted a comparison and analysis of the extent of DNA degradation in Chestnut rose juice or beverage by utilizing the amplicon size.
Methods
The quantity and quality of the extracted DNA were assessed using NanoDrop One spectrophotometer, gel electrophoresis, and real-time PCR assays. An assessment was conducted on the processing time, labor intensity, and cost associated with each approach. The degree of DNA degradation in Chestnut rose juice or beverage was also assessed using TaqMan real-time PCR methods.
Results
It was demonstrated that the DNA was extracted using a non-commercial modified CTAB-based approach, resulting in a high concentration. However, the spectrophotometric results and real-time PCR analysis indicated poor DNA quality. The combination approach showed the greatest performance among the extraction methods, while being comparatively time-consuming and costly in contrast to the other methods. Additionally, the analytical findings of DNA degradation suggested that the integrity of sample DNA could be influenced by the intricacy of processing methods used by various manufacturers.
Conclusions
To achieve precise DNA quantification, selecting suitable extraction strategies for the given matrix is necessary. The combination approach was identified as the most effective DNA extraction technique and is suggested for extracting DNA from Chestnut Rose Juices and Beverages. This comparative assessment can be particularly valuable for extracting and identifying processed Juices and Beverages in a diverse range of food compositions.