bluuebunny/crossref_metadata_2025_split huggingface dataset:
Intestinal microbiota by angiotensin receptor blocker therapy exerts protective effects against hypertensive damages
Authors: Li Jing , Wang Si‐Yuan , Yan Kai‐Xin , Wang Pan , Jiao Jie , Wang Yi‐Dan , Chen Mu‐Lei , Dong Ying , Zhong Jiu‐Chang 
Published: July 2024

AbstractDysbiosis of the gut microbiota has been implicated in hypertension, and drug–host–microbiome interactions have drawn considerable attention. However, the influence of angiotensin receptor blocker (ARB)‐shaped gut microbiota on the host is not fully understood. In this work, we assessed the alterations of blood pressure (BP), vasculatures, and intestines following ARB‐modified gut microbiome treatment and evaluated the changes in the intestinal transcriptome and serum metabolome in hypertensive rats. Hypertensive patients with well‐controlled BP under ARB therapy were recruited as human donors, spontaneously hypertensive rats (SHRs) receiving normal saline or valsartan were considered animal donors, and SHRs were regarded as recipients. Histological and immunofluorescence staining was used to assess the aorta and small intestine, and 16S rRNA amplicon sequencing was performed to examine gut bacteria. Transcriptome and metabonomic analyses were conducted to determine the intestinal transcriptome and serum metabolome, respectively. Notably, ARB‐modified fecal microbiota transplantation (FMT), results in marked decreases in systolic BP levels, collagen deposition and reactive oxygen species accumulation in the vasculature, and alleviated intestinal structure impairments in SHRs. These changes were linked with the reconstruction of the gut microbiota in SHR recipients post‐FMT, especially with a decreased abundance of Lactobacillus, Aggregatibacter, and Desulfovibrio. Moreover, ARB‐treated microbes contributed to increased intestinal Ciart, Per1, Per2, Per3, and Cipc gene levels and decreased Nfil3 and Arntl expression were detected in response to ARB‐treated microbes. More importantly, circulating metabolites were dramatically reduced in ARB‐FMT rats, including 6beta‐Hydroxytestosterone and Thromboxane B2. In conclusion, ARB‐modified gut microbiota exerts protective roles in vascular remodeling and injury, metabolic abnormality and intestinal dysfunctions, suggesting a pivotal role in mitigating hypertension and providing insights into the cross‐talk between antihypertensive medicines and the gut microbiome.
A fuzzy approach to economic freedom performance
Authors: Benli Muhammed , Çağlar Ahmet 
Published: July 2024

AbstractThis study aims to determine the most important component of economic freedom and to rank the performance of countries using multiple criteria decision‐making tools within the context of fuzzy set theory. To do so, we utilize a combination of fuzzy entropy weighting and fuzzy technique for order of preference by similarity to ideal solution (TOPSIS) methods to assess the economic freedom performance of 122 countries for the period 2000–2020. The findings suggest that the stability and reliability of a country's monetary system is the most crucial attribute for economic freedom performance. This implies that a stable and reliable monetary system is considered a fundamental aspect of economic freedom. Based on the TOPSIS analysis, the top 10 best‐performing countries/regions in terms of economic freedom are Hong Kong, Singapore, Switzerland, New Zealand, the United States, the United Kingdom, Australia, Canada, Denmark, and Ireland. On the other hand, Venezuela, Myanmar, Congo Republic, Algeria, Syrian Arab Republic, Congo Democratic Republic, Zimbabwe, Central African Republic, Chad, and Iran are the worst‐performing countries.
Beyond the mind: Understanding the influence of mental health on youth NEET status in Europe—A systematic literature review
Authors: Lindblad Victoria , Ravn Rasmus L. , Gaardsted Pernille S. , Hansen Line E. M. , Lauritzen Fie F. , Melgaard Dorte 
Published: July 2024

AbstractIntroductionIn the fields of labor market and education research, there is a vast interest in mental health factors affecting unsuccessful school‐to‐work transitions, dropout from school and labor market disconnections for young people. Young people who are not in employment, education or training are conceived of as NEET.AimTo get an overview we conducted a systematic review of the present literature on the influence of mental health on the likelihood of becoming NEET in Europe.MethodA Systematic literature search was conducted in four databases on February 21, 2023, with an update on January 15, 2024.Results33,314 articles were screened whereas 41 studies involving 8,914,123 individuals were included. Poor mental health such as attention deficit hyperactive disorder, autism, depression, borderline, and psychosis during childhood and adolescence is strongly associated with becoming NEET.ConclusionMental health issues, whether mild or severe, heighten significant the risk of adverse education and employment outcomes in early adulthood, extending to young individuals with personality disorders, borderline personality disorder, and psychoses. These observations inform early intervention strategies for children and young people grappling with mental health challenges. Timely treatment is essential. Future research should focus on the gap in research like specific disorders such as eating disorders and anxiety.
Doxycycline‐loaded carboxymethyl cellulose/sodium alginate/gelatin hydrogel: An approach for enhancing pressure ulcer healing in a rat model
Authors: Aldaghi Niloofar , Kamalabadi‐Farahani Mohammad , Alizadeh Morteza , Salehi Majid 
Published: July 2024

AbstractPressure ulcers, or bedsores, are created by areas of the skin under prolonged pressure and can lead to skin and underlying tissue damage. The present study evaluated the effects of carboxymethyl cellulose/sodium alginate/gelatin (CMC/Alg/Gel) hydrogel containing doxycycline (DOX) on improving the healing process of pressure ulcers. The magnet was used to apply pressure on the dorsum skin rat to induce a pressure ulcer model. Then sterile gauze, CMC/Alg/Gel, and CMC/Alg/Gel/1% w/v DOX hydrogels were used to cover the wounds. Blood compatibility, weight loss, cytocompatibility, drug release rate, cell viability, wound closure, and re‐epithelialization were evaluated in all animals on the 14th day after treatment. In vivo results and histopathological evaluation showed 56.66% wound closure and the highest re‐epithelialization in the CMC/Alg/Gel/1% w/v DOX hydrogel group (14 days after treatment). Furthermore, real‐time PCR results indicated that the hydrogel containing DOX significantly decreased the expression of the MMP family consisting of MMP2 and MMP9 mRNA and also increased the expression of vascular endothelial growth factor VEGF mRNA. This study suggested that the addition of DOX, an antibiotic and MMP inhibitor, to hydrogels may be effective in the healing process of pressure ulcers.
Prediction of intraoperative surgical difficulty during laparoscopic cholecystectomy using drip infusion cholangiography with computed tomography
Authors: Fujinaga Atsuro , Hirashita Teijiro , Endo Yuichi , Orimoto Hiroki , Amano Shota , Kawamura Masahiro , Kawasaki Takahide , Masuda Takashi , Inomata Masafumi 
Published: July 2024

AbstractBackgroundAlthough findings from drip infusion cholangiography with computed tomography (DIC‐CT) are useful in preoperative anatomic evaluation for laparoscopic cholecystectomy (LC), their relationship with intraoperative surgical difficulty based on the difficulty score (DS) proposed by Tokyo Guidelines 2018 is unclear. We examined this relationship.MethodsData were collected from 202 patients who underwent LC for benign gallbladder (GB) disease with preoperative DIC‐CT in our department. DIC‐CT findings were classified into GB‐positive and GB‐negative groups based on GB opacification, and clinical characteristics were compared. DS assessed only on findings from around Calot's triangle was considered “cDS”, and patients were divided into cDS ≤2 and ≥3 groups. Preoperative data including DIC‐CT findings were evaluated using multivariate analysis.ResultsDIC‐CT findings showed 151 (74.8%) GB‐positive and 51 (25.2%) GB‐negative patients. Surgical outcomes were significantly better in the GB‐positive versus GB‐negative group for operation time (107 vs. 154 min, p < .001), blood loss (8 vs. 25 mL, p < .001), cDS (0.8 vs. 2.2, p < .001), and critical view of safety score (4.0 vs. 3.1, p < .001). cDS was ≤2 in 174 (86.1%) and ≥3 in 28 (13.9%) patients. By multivariate analysis, DIC‐CT findings and alkaline phosphatase values were independent factors predicting intraoperative difficulty.ConclusionDIC‐CT findings are useful for predicting cDS in LC.
Metal Halide Perovskites Blue Emitters and Light‐Emitting Diodes: A Review on Morphological and Molecular Dimensions
Authors: Gao Long , Gong Yuyan , Zhang Xiaoyu , Yip Hin‐Lap , Shen Liang , Zhang Jiaqi 
Published: July 2024

AbstractMetal halide perovskites have recently garnered significant attention as a fundamental emitter due to their high carrier mobility, strong light absorption, high monochromaticity, and tunable emission bandgap. However, the brightness, efficiency, and stability issues have limited their potential applications in blue region. To break through these limitations, researchers have investigated different dimensions of perovskites to seek an excellent emitter. To date, the quantum confinement and coordination octahedron monomer arrangement perovskites still lack of systematic cognition. In this review, the molecular and morphological dimensions of blue perovskite emitters are summarized. The differences and relationships between these dimensions in terms of their fabrication and properties are also explored. Furthermore, recent advances in blue light enhancement strategies to address the challenges in various morphological and molecular structures are highlighted. Finally, the main challenges and future directions are discussed for the development of perovskite blue LEDs.
The Allergen Profile of Two Edible Insect Species—Acheta domesticus and Hermetia illucens
Authors: Karnaneedi Shaymaviswanathan , Johnston Elecia B. , Bose Utpal , Juhász Angéla , Broadbent James A. , Ruethers Thimo , Jerry Emily M. , Kamath Sandip D. , Limviphuvadh Vachiranee , Stockwell Sally , Byrne Keren , Clarke Dean , Colgrave Michelle L. , Maurer‐Stroh Sebastian , Lopata Andreas L. 
Published: July 2024

ScopeEdible insect proteins are increasingly introduced as an alternative sustainable food source to address the world's need to feed the growing population. Tropomyosin is the main insect allergen; however, additional potential allergens are not well characterized and the impact of extraction procedures on immunological reactivity is unknown.Methods and resultsProteins from different commercial food products derived from cricket (Acheta domesticus) and black soldier fly (BSF) (Hermetia illucens) are extracted using five different extraction buffers. The proteins are analyzed by SDS‐PAGE and immunoblotting using allergen‐specific antibodies and crustacean allergic patient sera. IgE binding bands are analyzed by mass spectrometry as well as the complete allergen profile of all 30 extracts. Urea‐based buffers are most efficient in extracting insect allergens. Shrimp‐specific antibody cross‐reactivity to tropomyosin from cricket and BSF indicates high sequence and structural similarity between shrimp and insects. Additional unique allergens are identified in both species, including hemocyanin, vitellogenin, HSP20, apolipophorin‐III, and chitin‐binding protein.ConclusionsIdentifying potential allergenic proteins and their isoforms in cricket and BSF requires specific extraction approaches using urea‐based methods. While tropomyosin is the most abundant and immunoreactive allergen, seven unique allergens are identified, highlighting the need for insect species‐specific allergen detection in food products.
Interfacial flow contact resistance effect for thermal consolidation of layered viscoelastic saturated soils with semi‐permeable boundaries
Authors: Xie Jiahao , Wen Minjie , Ding Pan , Tu Yuan , Wu Dazhi , Liu Kaifu , Tang Kejie , Chen Menghuan 
Published: July 2024

AbstractLaminar flow phenomena may occur when pore water flows at low velocities across the interfaces between soils of different properties, thus causing flow contact resistance. To explore the impacts of interfacial flow contact resistance and rheological characteristics on the thermal consolidation process of layered viscoelastic saturated soil foundation featuring semi‐permeable boundaries. This paper established a new thermal consolidation model by introducing a fractional order derivative model, Hagen–Poiseuille law and time‐dependent loadings. The semi‐analytical solutions for the proposed thermal consolidation model are derived through the Laplace transform and its inverse transform. The reliability and correctness of the solutions are verified with the experimental data in literatures. The influence of constitutive parameters, flow contact resistance model parameters on thermal consolidation process and the interfacial flow contact resistance on foundation settlement, is further explored. The results indicate that the impact of the constitutive parameters and permeability coefficient on the thermal consolidation of viscoelastic saturated soil is related to the flow contact resistance. The enhanced flow contact resistance effect leads to a significant increase in pore water pressure and displacement during the consolidation process.
An improved discretization‐based kinematic approach for stability analyses of nonuniform c‐φ soil slopes
Authors: Wang Hongyu , Meng Lingchao , Qin Changbing 
Published: July 2024

AbstractThis paper proposes an improved discretization‐based kinematic approach (DKA) with an efficient and robust algorithm to investigate slope stability in nonuniform soils. In an effort to ensure rigorous upper‐bound solutions which may be not satisfied by the initial DKA based on a forward difference method (DKA‐FD), a central and backward difference “point‐to‐point” method (DKA‐CD and DKA‐BD) is proposed to generate discretized points to form a velocity discontinuity surface. Varying (including constant) soil frictional angles along depth are discussed, which can be readily considered in the improved DKA‐CD. Work rate calculations are performed to derive upper‐bound formulations of slope stability number, and critical failure surface is correspondingly obtained at limit state. The comparison with forward and backward difference methods clearly reveals that the improved DKA‐CD could significantly reduce the mesh‐dependency issue and enhance efficacy of slope stability analyses in nonuniform soils.
Granular material regime transitions during high energy impacts of dry flowing masses: MPM simulations with a multi‐regime constitutive model
Authors: Marveggio Pietro , Zerbi Matteo , Redaelli Irene , di Prisco Claudio 
Published: July 2024

AbstractThe dynamic interaction between granular flowing masses and rigid obstacles is a complex phenomenon characterised by both large displacements and high strain rates. In case the flowing mass is modelled as a continuum, its numerical simulation requires both advanced computational tools and constitutive relationships capable of predicting the mechanical behaviour of the same material under both fluid and solid regimes. In this paper, the authors employed the open‐source ANURA3D code, based on the Material Point Method (MPM), and a multi‐regime constitutive model. A series of impacts characterised by different velocities, initial void ratios, front inclinations and impacting mass lengths have been simulated. The MPM numerical results are critically compared with those obtained by using a Discrete Element Method (DEM) numerical code. The model capability of simulating material regime transitions, from fluid to solid and vice versa, is shown to be crucial for reproducing the mechanical response of the flowing mass put in evidence by DEM data.
A Review: CRISPR Cas System and the Mechanism With an Inhibition of Binding of CRISPR Cas‐9
Authors: Hosen Akram , Nishat Md Nakibul Hasan , Soaib MD. Mohaimin Hossain , Sharkar Omar Sharif , Sahabuddin Md. , Sharif Imdadul Haque , Bhajan Sujay Kumar 
Published: July 2024

ABSTRACTCRISPR Cas system is a revolutionary and precise genome editing system that induces bacterial and archaeal adaptive immunity and already has shown several promising applications in the treatment of genetic diseases and detection of nucleic acid targets. It is a complex tool, comprising diverse effector proteins and guide RNA that can be applied to dissociate and modify genes in living organisms along with the in vitro process. The review concentrates on the advances accomplished from some recent years to 2023 for the emergence of predicting actions of Cas protein with the guide RNA (gRNA), playing a key role in genome editing. This review emphasizes the effect of DNA structure and chromosomal protein on Cas 9 binding with a distinct classification of Cas types. The relevance of this review is highlighted by the significance of the rapid development of wide study methods and their potential impacts on the efficiency of the CRISPR Cas system. We have analyzed recent kinds of literature in this work to integrate a deep learning way that contributes over the next time with some important discussion about viral resistance in eukaryotes along with some cancer treatment strategies, and crop improvement by the CRISPR Cas system.
Assessing the success of a research leadership programme for senior nurses and midwives: A mixed methods programme evaluation
Authors: Menzies Julie Christine , Ford Rachel , Henshall Catherine 
Published: July 2024

AbstractAimsIn 2018 the National Institute of Health and Care Research, United Kingdom, launched a 3‐year Senior Nurse and Midwife Research Leader Programme to support nurse and midwifery research leaders to develop research capacity and capability within NHS organisations. We report the results of a service evaluation of the programme strengths, areas for improvement and achievement of programme aims.DesignPartially mixed, concurrent mixed methods programme evaluation, including: (a) meeting evaluation (survey), (b) annual evaluation (survey) and (c) qualitative stakeholder interviews.MethodsSurvey results were quantitatively analysed using descriptive statistics. Interviews were audio‐recorded, transcribed, deductively coded using elements within the logic model and analysed using the seven‐stage framework analysis method.ResultsSatisfaction with the programme was high (75%). The main perceived benefit of the programme was being part of a network. Challenges included accessing learning resources, lack of opportunity to network and lack of clarity about the programme aims. Meetings were evaluated as relevant and helpful (mean 93%), thought‐provoking (92%), inspiring (91%), at the appropriate level (91%) and aligned with the programme aims (90%). All meetings were ranked as highly beneficial by attendees (92%). Stakeholder feedback on the programme success reflected the importance of leadership, the programme design and content, ‘connection and community’ and communication with and about the cohort. Overall, the anticipated programme aims were met, evaluating well from both the perspective of those on the programme and the wider stakeholder group. There has been a lack of investment in schemes to support research leadership development for nurses/midwives. A novel programme to support nursing/midwifery research leadership was positively evaluated. The programme is a useful model to support future capacity and capability building for nurses/midwives. The work is reported with reference to the SQUIRE 2 and SRQR checklists. No patient or public contribution.
Fas (CD95) expression in adipocytes contributes to diet‐induced obesity
Authors: Wueest Stephan , Scaffidi Chiara , van Krieken Pim P. , Konrad Nils K. , Koch Christian , Wiedemann Michael S. F. , Goergen Anne , Borsigova Marcela , Lempesis Ioannis G. , Fullin Jonas , Manolopoulos Konstantinos N. , Böttcher Steffen , Goossens Gijs H. , Blüher Matthias , Konrad Daniel 
Published: July 2024

AbstractObjectiveInduction of browning in white adipose tissue (WAT) increases energy expenditure and may be an attractive target for the treatment of obesity. Since activation of Fas (CD95) induces pathways known to blunt expression of uncoupling protein 1 (UCP1), we hypothesized that Fas expression in adipocytes inhibits WAT browning and thus contributes to the development of obesity.MethodsAdipocyte‐specific Fas knockout (FasΔadipo) and control littermate (FasF/F) mice were fed a regular chow diet or a high‐fat diet (HFD) for 20 weeks. Energy expenditure was assessed by indirect calorimetry, and browning was determined in subcutaneous WAT. In vitro, UCP1 was analyzed in subcutaneous murine adipocytes treated with or without Fas ligand. Moreover, FAS expression in WAT was correlated to UCP1 and percentage of body fat in human individuals.ResultsHFD‐fed FasΔadipo mice displayed reduced body weight gain and blunted adiposity compared to control littermates. Concomitantly, whole‐body energy expenditure and WAT browning were elevated. In cultured adipocytes, Fas ligand treatment blunted isoproterenol‐induced UCP1 protein levels. In support of these findings in rodents, FAS expression in WAT correlated negatively with UCP1 but positively with adiposity in human individuals.ConclusionsFas activation in adipocytes contributes to HFD‐associated adiposity in rodents and may be a therapeutic target to reduce obesity and associated diseases.
Koopman‐based 3‐dimensional path following control for robotic flexible needles
Authors: Zhang Nianhua , Qi Zhi , Chen Jicheng , Zhang Hui , Karimi Hamid Reza 
Published: July 2024

AbstractRobotic flexible needles have gained significant attention in minimally invasive medical procedures due to their ability to navigate complex anatomical structures and reach targets with high precision. Addressing the complex control problem in a 3‐dimensional environment, a Koopman‐based data‐driven control strategy is proposed in this paper. First, a 3‐dimensional (3D) path tracking problem is modeled using the simplified high‐dimensional bicycle model with the puncture kinematic. Then, with the Koopman operator theory, a finite linear approximation is designed and trained to simplify the nonlinear system of flexible needles. Finally, based on the linear approximation, a Koopman‐based model predictive control (MPC) scheme is proposed to realize 3‐dimensional path tracking for flexible needles. Based on simulations, the linear approximation and data‐driven control strategy are validated.