bluuebunny/crossref_metadata_2025_split huggingface dataset:
Does High Knee Flexion Cause Separation of Meniscal Repairs?
Authors: Lin David L. , Ruh Sarah S. , Jones Hugh L. , Karim Azim , Noble Philip C. , McCulloch Patrick C. 
Published: July 2013

Background: Previous clinical studies comparing nonrestrictive and restrictive protocols after meniscal repair have shown no difference in outcomes; however, some surgeons still limit range of motion out of concern that it will place undue stress on the repair. Hypothesis: Large acute medial meniscal tears will gap during simulated open chain exercises at high flexion angles, and a repaired construct with vertical mattress sutures will not gap. Study Design: Controlled laboratory study. Methods: Tantalum beads were implanted in the medial menisci of 6 fresh-frozen cadaveric knees via an open posteromedial approach. Each knee underwent 10 simulated open chain flexion cycles with loading of the quadriceps and hamstrings. Testing was performed on 3 different states of the meniscus: intact, torn, and repaired. Biplanar radiographs were taken of the loaded knee in 90°, 110°, and 135° of flexion for each state. A 2.5-cm tear was created in the posteromedial meniscus and repaired with inside-out vertical mattress sutures. Displacement of pairs of beads spanning the tear was measured in all planes by use of radiostereometric analysis (RSA) with an accuracy of better than 80 μm. Results: With a longitudinal tear, compression rather than gapping occurred in all 3 regions of the posterior horn of the meniscus (mean ± standard deviation for medial collateral ligament [MCL], –321 ± 320 μm; midposterior, –487 ± 256 μm; root, –318 ± 150 μm) with knee flexion. After repair, meniscal displacement returned part way to intact values in both the MCL (+55 ± 250 μm) and root region (–170 ± 123 μm) but not the midposterior region, where further compression was seen (–661 ± 278 μm). Conclusions: Acute posteromedial meniscal tears and repairs with vertical mattress sutures do not gap, but rather compress in the transverse plane at higher flexion angles when subjected to physiologic loads consistent with active, open kinetic chain range of motion rehabilitation exercises. The kinematics of the repaired meniscus more closely resemble that of the intact meniscus than that of the torn meniscus in regions adjacent to the MCL and the root but not in the midposterior region, where meniscal repair led to increased compression across the tear plane. Clinical Relevance: This study supports the idea that nonrestrictive unresisted open chain range of motion protocols do not place undue stress on meniscal repairs.
Mobbing in Health Sector: Sample of University Hospital
Authors: Somunoğlu Sinem , Gedik Ayçin , Kurt Derya Erol , Eygi Gökhan , Gebedek Şayeste , Ilhan Yasemin , Sağ Züleyha 
Published: July 2013

It has been pointed out that mobbing is one of the major problem areas in the health sector in recent years. To identify the presence of mobbing, this study was conducted in a university hospital located in Zonguldak city. When the mobbing behaviours against nurses were examined, mobbing was listed as a humiliating and unfavourable communication (57.8%), verbal threats (26.2%), physical attacks (5.9%), verbal or behavioural sexual attacks (8%), and prevention of self-improvement opportunities (17.6%). When the most frequent mobbing practicer were asked, the answer was given as the patients. Nurses considered changing their organizations or quitting their job because of mobbing. The article suggests increasing awareness of mobbing among nurses.
The Nomenclature and Classification of Human Resources for Health: A Review
Authors: Kumar Binay , Sharma Kavya , Zodpey Sanjay 
Published: July 2013

This article attempts to answer the obvious question of who are the people that can be included in the definition of Human Resources for Health and what might they be called. To answer the question an extensive search of literature was conducted. The search was aimed at identifying the nomenclature and classifications of human resources for health. The search resulted in a variety of nomenclature and a large number of classification frameworks which were then narrowed down to seven frameworks. It was found that there is a lot of overlap in the definitions used for various nomenclatures. The terms ‘health workers’ and ‘public health workers’ are a major area of disagreement and confusion. The classifications also indicated a lot of difference of opinions on who should be included in the various categories suggested in the different classifications. However, almost all these classifications identify at least three major categories of health workers; the specialist health workers, the specialist public health workers and the health management/support workers. The article points out an important area which is generally neglected in the human resource policy making. An attention to better classification can have a tremendous impact on human resource planning and monitoring.
Analysis of Nursing Job Characteristics in Public Sector Hospitals
Authors: Mariappan M. 
Published: July 2013

Background: Significance of any job depends on the strong presence of job characteristics which can positively improve motivation, performance and job satisfaction. Methodology: A structured interview scheduled was administered among 317 nurses in five BMC hospitals. The data were analyzed with the help of SPSS by using simple statistical tools. Results: Overall 66 per cent of the nursing staff found that the job is meaningful to them; 64.5 per cent of the staff feels that job design supports job satisfaction significantly. Conclusion: Nursing job contributes to well-being of human hence, it is treated as significant however the present job design did not make any positive support to their motivation and performance. This is due to inadequate presence of job characteristics.
Testing the incremental predictive accuracy of new markers
Authors: Begg Colin B , Gonen Mithat , Seshan Venkatraman E 
Published: July 2013

Background It has become commonplace to use receiver operating curve (ROC) methodology to evaluate the incremental predictive accuracy of new markers in the presence of existing predictors. However, concerns have been raised about the validity of this practice. We have evaluated this issue in detail. Results Simulations have been used that show clearly that use of risk predictors from nested models as data in subsequent tests comparing areas under the ROC curves of the models leads to grossly invalid inferences. Careful examination of the issue reveals two major problems: (1) the data elements are strongly correlated from case to case and (2) the model that includes the additional marker has a tendency to interpret predictive contributions as positive information regardless of whether observed effect of the marker is negative or positive. Both of these phenomena lead to profound bias in the test. Conclusions We recommend strongly against the use of ROC methods derived from risk predictors from nested regression models to test the incremental information of a new marker.
Loss of the F-BAR protein CIP4 reduces platelet production by impairing membrane-cytoskeleton remodeling
Authors: Chen Yolande , Aardema Jorie , Kale Sayali , Whichard Zakary L. , Awomolo Arinola , Blanchard Elisabeth , Chang Brian , Myers David R. , Ju Lining , Tran Reginald , Reece David , Christensen Hilary , Boukour Siham , Debili Najet , Strom Ted S. , Rawlings David , Vázquez Francisco X. , Voth Gregory A. , Zhu Cheng , Kahr Walter H. A. , Lam Wilbur A. , Corey Seth J. 
Published: July 2013

Key PointsCIP4 affects the remodeling of both plasma membrane and cortical cytoskeleton in megakaryocytes. CIP4 in platelet biogenesis involves cortical tension, as does WASP, and WASP-independent plasma membrane reorganization.
DEPTOR regulates vascular endothelial cell activation and proinflammatory and angiogenic responses
Authors: Bruneau Sarah , Nakayama Hironao , Woda Craig B. , Flynn Evelyn A. , Briscoe David M. 
Published: July 2013

Key PointsDEPTOR is expressed in vascular endothelial cells and serves as an endogenous inhibitor of mTORC1, ERK1/2, and STAT1 activity. DEPTOR is potent to regulate endothelial cell expression of chemokines and adhesion molecules, leukocyte-endothelial adhesion, and endothelial migratory responses.
Retracted Article: On the Kirchhoff matrix, a new Kirchhoff index and the Kirchhoff energy
Authors: Maden Ayse Dilek , Cevik Ahmet Sinan , Cangul Ismail Naci , Das Kinkar C 
Published: July 2013

Abstract

Abstract
The main purpose of this paper is to define and investigate the Kirchhoff matrix, a new Kirchhoff index, the Kirchhoff energy and the Kirchhoff Estrada index of a graph. In addition, we establish upper and lower bounds for these new indexes and energy. In the final section, we point out a new possible application area for graphs by considering this new Kirchhoff matrix. Since graph theoretical studies (including graph parameters) consist of some fixed point techniques, they have been applied in the fields such as chemistry (in the meaning of atoms, molecules, energy etc.) and engineering (in the meaning of signal processing etc.), game theory, and physics.

MSC: 05C12, 05C50, 05C90.
Reannotation and extended community resources for the genome of the non-seed plant Physcomitrella patens provide insights into the evolution of plant gene structures and functions
Authors: Zimmer Andreas D , Lang Daniel , Buchta Karol , Rombauts Stephane , Nishiyama Tomoaki , Hasebe Mitsuyasu , Van de Peer Yves , Rensing Stefan A , Reski Ralf 
Published: July 2013

Abstract

Background
The moss Physcomitrella patens as a model species provides an important reference for early-diverging lineages of plants and the release of the genome in 2008 opened the doors to genome-wide studies. The usability of a reference genome greatly depends on the quality of the annotation and the availability of centralized community resources. Therefore, in the light of accumulating evidence for missing genes, fragmentary gene structures, false annotations and a low rate of functional annotations on the original release, we decided to improve the moss genome annotation.

Results
Here, we report the complete moss genome re-annotation (designated V1.6) incorporating the increased transcript availability from a multitude of developmental stages and tissue types. We demonstrate the utility of the improved P. patens genome annotation for comparative genomics and new extensions to the cosmoss.org resource as a central repository for this plant “flagship” genome. The structural annotation of 32,275 protein-coding genes results in 8387 additional loci including 1456 loci with known protein domains or homologs in Plantae. This is the first release to include information on transcript isoforms, suggesting alternative splicing events for at least 10.8% of the loci. Furthermore, this release now also provides information on non-protein-coding loci. Functional annotations were improved regarding quality and coverage, resulting in 58% annotated loci (previously: 41%) that comprise also 7200 additional loci with GO annotations. Access and manual curation of the functional and structural genome annotation is provided via the http://www.cosmoss.org model organism database.

Conclusions
Comparative analysis of gene structure evolution along the green plant lineage provides novel insights, such as a comparatively high number of loci with 5’-UTR introns in the moss. Comparative analysis of functional annotations reveals expansions of moss house-keeping and metabolic genes and further possibly adaptive, lineage-specific expansions and gains including at least 13% orphan genes.
Outcomes following renal transplantation in older people: a retrospective cohort study
Authors: Dempster Niall J , Ceresa Carlo DL , Aitken Emma , Kingsmore David 
Published: July 2013

AbstractBackgroundThe mean age of renal transplant recipients is rising, with age no longer considered a contraindication. Outcomes in older patients have not, however, been fully defined. The aim of our study is to evaluate outcomes in older people following renal transplantation at a Scottish regional transplant unit.MethodsAll renal transplants from January 2001 to December 2010 were analysed (n = 762). Outcomes following renal transplantation in people over 65 years old were compared to those in younger patients. Outcome measures were: delayed graft function (DGF), primary non-function (PNF), biopsy proven acute rejection (BPAR), serum creatinine at 1 year and graft and recipient survival. Lengths of initial hospital stay and re-admission rates were also assessed. Student’s T-Test was used to analyse continuous variables, Pearson’s Chi-Squared test for categorical variables and the Kaplan-Meier estimator for survival analysis.ResultsOlder recipients received proportionately more kidneys from older donors (27.1% vs. 6.3%; p  <  0.001). Such kidneys were more likely to have DGF (40.7% vs. 16.9%; p < 0.001). Graft loss at 1 year was higher in kidneys from older donors (15.3% vs. 7.6%; p = 0.04). There was no significant difference in patient survival at 1 year based on the age of the donor kidney. Recipient age did not affect DGF (16.9% vs. 18.5%; p = 0.77) or graft loss at 1 year (11.9% vs. 7.8%; p = 0.28). Older recipients were, however, more likely to die in the first year post transplant (6.8% vs. 2.1%; p = 0.03). BPAR was less common in older patients (6.8% vs. 22%; p < 0.01). Older recipients were more likely to be readmitted to hospital (31.8% vs. 10.9%; p < 0.001).ConclusionsOlder patients experience good outcomes following renal transplantation and donor or recipient age alone should not preclude this treatment. An awareness of this in clinicians managing older patients is important since the prevalence of End Stage Renal Disease is increasing in this age group.
Addition of host genetic variants in a prediction rule for post meningitis hearing loss in childhood: a model updating study
Authors: Sanders Marieke S , de Jonge Rogier CJ , Terwee Caroline B , Heymans Martijn W , Koomen Irene , Ouburg Sander , Spanjaard Lodewijk , Morré Servaas A , van Furth A Marceline 
Published: July 2013

Abstract

Background
Sensorineural hearing loss is the most common sequela in survivors of bacterial meningitis (BM). In the past we developed a validated prediction model to identify children at risk for post-meningitis hearing loss. It is known that host genetic variations, besides clinical factors, contribute to severity and outcome of BM. In this study it was determined whether host genetic risk factors improve the predictive abilities of an existing model regarding hearing loss after childhood BM.

Methods
Four hundred and seventy-one Dutch Caucasian childhood BM were genotyped for 11 single nucleotide polymorphisms (SNPs) in seven different genes involved in pathogen recognition. Genetic data were added to the original clinical prediction model and performance of new models was compared to the original model by likelihood ratio tests and the area under the curve (AUC) of the receiver operating characteristic curves.

Results
Addition of TLR9-1237 SNPs and the combination of TLR2 + 2477 and TLR4 + 896 SNPs improved the clinical prediction model, but not significantly (increase of AUC’s from 0.856 to 0.861 and from 0.856 to 0.875 (p = 0.570 and 0.335, respectively). Other SNPs analysed were not linked to hearing loss.

Conclusions
Although addition of genetic risk factors did not significantly improve the clinical prediction model for post-meningitis hearing loss, AUC’s of the pre-existing model remain high after addition of genetic factors. Future studies should evaluate whether more combinations of SNPs in larger cohorts has an additional value to the existing prediction model for post meningitis hearing loss.
Clinical course of sepsis, severe sepsis, and septic shock in a cohort of infected patients from ten Colombian hospitals
Authors: León Alba Luz , Hoyos Natalia Andrea , Barrera Lena Isabel , De La Rosa Gisela , Dennis Rodolfo , Dueñas Carmelo , Granados Marcela , Londoño Dario , Rodríguez Ferney Alexander , Molina Francisco José , Ortiz Guillermo , Jaimes Fabián Alberto 
Published: July 2013

Abstract

Background
Sepsis has several clinical stages, and mortality rates are different for each stage. Our goal was to establish the evolution and the determinants of the progression of clinical stages, from infection to septic shock, over the first week, as well as their relationship to 7-day and 28-day mortality.

Methods
This is a secondary analysis of a multicenter cohort of inpatients hospitalized in general wards or intensive care units (ICUs). The general estimating equations (GEE) model was used to estimate the risk of progression and the determinants of stages of infection over the first week. Cox regression with time-dependent covariates and fixed covariates was used to determine the factors related with 7-day and 28-day mortality, respectively.

Results
In 2681 patients we show that progression to severe sepsis and septic shock increases with intraabdominal and respiratory sources of infection [OR = 1,32; 95%IC = 1,20-1,46 and OR = 1.21, 95%CI = 1,11-1,33 respectively], as well as according to Acute Physiology and Chronic Health Evaluation II (APACHE II) [OR = 1,03; 95%CI = 1,02-1,03] and Sequential Organ Failure Assessment (SOFA) [OR = 1,16; 95%CI = 1,14-1,17] scores. The variables related with first-week mortality were progression to severe sepsis [HR = 2,13; 95%CI = 1,13-4,03] and septic shock [HR = 3,00; 95%CI = 1,50-5.98], respiratory source of infection [HR = 1,76; 95%IC = 1,12-2,77], APACHE II [HR = 1,07; 95% CI = 1,04-1,10] and SOFA [HR = 1,09; 95%IC = 1,04-1,15] scores.

Conclusions
Intraabdominal and respiratory sources of infection, independently of SOFA and APACHE II scores, increase the risk of clinical progression to more severe stages of sepsis; and these factors, together with progression of the infection itself, are the main determinants of 7-day and 28-day mortality.
Parallel analysis of finite element model controlled trial and retrospective case control study on percutaneous internal fixation for vertical sacral fractures
Authors: Chen Hongwei , Wu Lijun , Zheng Rongmei , Liu Yan , Li Yang , Ding Zihai 
Published: July 2013

AbstractBackgroundAlthough percutaneous posterior-ring tension-band metallic plate and percutaneous iliosacral screws are used to fix unstable posterior pelvic ring fractures, the biomechanical stability and compatibility of both internal fixation techniques for the treatment of Denis I, II and III type vertical sacral fractures remain unclear.MethodsUsing CT and MR images of the second generation of Chinese Digitized Human “male No. 23”, two groups of finite element models were developed for Denis I, II and III type vertical sacral fractures with ipsilateral superior and inferior pubic ramus fractures treated with either a percutaneous metallic plate or a percutaneous screw. Accordingly, two groups of clinical cases that were fixed using the above-mentioned two internal fixation techniques were retrospectively evaluated to compare postoperative effect and function. Parallel analysis was performed with a finite element model controlled trial and a case control study.ResultsThe difference of the postoperative Majeed standards and outcome rates between two case groups was no statistically significant (P > 0.05). Accordingly, the high values of the maximum displacements/stresses of the plate-fixation model group approximated those of the screw-fixation model group. However, further simulation of Denis I, II and III type fractures in each group of models found that the biomechanics of the plate-fixation models became increasingly stable and compatible, whereas the biomechanics of the screw-fixation models maintained tiny fluctuations. When treating Denis III fractures, the biomechanical effects of the pelvic ring of the plate-fixation model were better than the screw-fixation model.ConclusionsPercutaneous plate and screw fixations are both appropriate for the treatment of Denis I and II type vertical sacral fractures; whereas percutaneous plate fixation appears be superior to percutaneous screw fixation for Denis III type vertical sacral fracture. Biomechanical evidence of finite element evaluations combined with clinical evidence will contribute to our ability to distinguish between indications that require plate or screw fixation for vertical sacral fractures.
Cost of illness of the stomach cancer in Japan - a time trend and future projections
Authors: Haga Kayoko , Matsumoto Kunichika , Kitazawa Takefumi , Seto Kanako , Fujita Shigeru , Hasegawa Tomonori 
Published: July 2013

Abstract

Background
Stomach cancer is one of the leading causes of cancer deaths in Japan. The objectives of this study were to estimate and project the economic burden associated with stomach cancer in Japan, and to identify the key factors that drive the economic burden of stomach cancer.

Methods
We calculated Cost of illness (COI) of 1996, 2002, 2008, 2014 and 2020 by using government office statistics and the COI method. We calculated direct cost and indirect cost (morbidity cost and mortality cost), and estimated the COI by summing them up.

Results
The number of deaths remained at approximately 50,000 in 1996–2008. COI was in downward trend from 1,293.5 billion yen in 1996 to 1,114.2 billion yen in 2008. Morbidity cost was 85.6 billion yen and 54.0 billion yen, mortality cost was 972.3 billion yen and 806.4 billion yen, and mortality cost per person was 19.4 million yen and 16.1 million yen in 1996 and 2008, respectively. Decrease of mortality cost that accounted for a large part of the COI (72.4% in 2008) was the major contributing factor. COI is predicted to decrease if the trend of health related indicators continues (442.8-1,056.1 billion yen depending on the model in 2020). Mortality cost per person is also predicted to decrease (9.5-12.5 million yen depending on the model in 2020).

Conclusions
If the trend of health related indicators continues, it is estimated that COI of stomach cancer would decrease. “Aging”, “change of the healthcare providing system” and “new medical technology” are considered as contributing factors of COI.
Polyunsaturated fatty acid relatively decreases cholesterol content in THP-1 macrophage-derived foam cell: partly correlates with expression profile of CIDE and PAT members
Authors: Song Yue , Zhang Li-Jun , Li Hang , Gu Yu , Li Fan-Fan , Jiang Li-Na , Liu Fang , Ye Jing , Li Qing 
Published: July 2013

Abstract

Background
Polyunsaturated fatty acids (PUFAs) have positive effect on the regulation of plasma lipids. But the mechanism for them to modulate lipid homeostasis in macrophage is still unclear. In this study, we employed PUFA to pretreat macrophages and evaluated the variations of lipid droplet (LD) content, lipid composition, and expressions of LD-associated genes in macrophage-derived foam cells.

Method
THP-1-derived macrophages or human peripheral blood monocyte-derived macrophages were pre-treated with four non-esterified fatty acids (NEFAs) separately: saturated fatty acid (SFA)-palmitic acid (PA), monounsaturated fatty acids (MUFAs)-oleic acid (OA), PUFAs-linoleic acid (LA) and eicosapentaenoic acid (EPA). Intracellular lipid content and cholesterol efflux were analyzed in THP-1 macrophage-derived foam cells. Related gene expressions were detected by quantitative real-time PCR.

Results
PUFA pre-treatment reduced cholesterol content in foam cells and increased cholesterol efflux to lipid-free apoAI in conditioned medium compared with PA or OA group. Cell death-inducing DFF45 like effector (CIDE) and Perilipin-Adipophilin-TIP47 (PAT) family members, as LD-associated proteins, showed specific gene expression profiles after PUFA pre-treatment. These results may help to explain the process of lipid metabolism within foam cells.

Conclusion
PUFA (LA or EPA) had a potential protective effect against cholesterol accumulation. The specific expressions of CIDE and PAT genes may provide clues to explore the protective mechanism of PUFA in foam cells.