bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optimal design of reduced vapor transfer dividing wall structures with and without heat integration
Authors: Duanmu Fanyi , Sorensen Eva 
Published: August 2024

AbstractA dividing wall column (DWC) is a prime example of process intensification, whereby significant energy and cost savings can be achieved for some systems compared to operation in conventional design of two columns in series. It has been theorized that the vapor and liquid thermal coupling streams in the DWC could be replaced by liquid‐only transfer streams, making the DWC unit less complex. The ultimate structure is the liquid‐liquid (LL) structure with all thermal coupling streams replaced and a dividing wall extending from the top to the bottom. This article compares the separation and economic performances of the regular DWC and the LL structure, and further investigates the benefits of heat‐integrated alternatives of both (combined condenser and reboiler, double‐effect, vapor recompression assisted). Optimization uncovered that vapor recompression assisted structures exhibit substantial energy savings and lowered total annualized cost but that the savings depend on electricity and utility costs.
The seasonal distribution of immune thrombotic thrombocytopenic purpura is influenced by geography: Epidemiologic findings from a multi‐center analysis of 719 disease episodes
Authors: Jacobs Jeremy W. , Stanek Caroline G. , Booth Garrett S. , Symeonidis Argiris , Shih Andrew W. , Allen Elizabeth S. , Gavriilaki Eleni , Grossman Brenda J. , Pavenski Katerina , Moorehead Amy , Peyvandi Flora , Agosti Pasquale , Mancini Ilaria , Stephens Laura D. , Raval Jay S. , Mingot‐Castellano Maria Eva , Crowe Elizabeth P. , Daou Laetitia , Pai Menaka , Arnold Donald M. , Marques Marisa B. , Henrie Ryan , Smith Tyler W. , Sreenivasan Gayatri , Siniard Rance C. , Wallace Lisa R. , Yamada Chisa , Duque Miriam Andrea , Wu Yanyun , Harrington Thomas J. , Byrnes Diana M. , Bitsani Aikaterini , Davis Amanda K. , Robinson Danielle H. , Eichbaum Quentin , Figueroa Villalba Cristina A. , Juskewitch Justin E. , Kaiafa Georgia , Kapsali Eleni , Klapper Ellen , Perez‐Alvarez Ingrid , Klein Monica S. , Kotsiou Nikolaos , Lalayanni Chrysavgi , Mandala Evdokia , Aldarweesh Fatima , Alkhateb Rahaf , Fortuny Lisandro , Mellios Zois , Papalexandri Apostolia , Parsons Meredith G. , Schlueter Annette J. , Tormey Christopher A. , Wellard Cameron , Wood Erica M. , Jia Shiyang , Wheeler Allison P. , Powers Amy A. , Webb Christopher B. , Yates Sean G. , Bouzid Raïda , Coppo Paul , Bloch Evan M. , Adkins Brian D. 
Published: August 2024

AbstractPrior studies have suggested that immune thrombotic thrombocytopenic purpura (iTTP) may display seasonal variation; however, methodologic limitations and sample sizes have diminished the ability to perform a rigorous assessment. This 5‐year retrospective study assessed the epidemiology of iTTP and determined whether it displays a seasonal pattern. Patients with both initial and relapsed iTTP (defined as a disintegrin and metalloprotease with thrombospondin type motifs 13 activity <10%) from 24 tertiary centers in Australia, Canada, France, Greece, Italy, Spain, and the US were included. Seasons were defined as: Northern Hemisphere—winter (December–February); spring (March–May); summer (June–August); autumn (September–November) and Southern Hemisphere—winter (June–August); spring (September–November); summer (December–February); autumn (March–May). Additional outcomes included the mean temperature in months with and without an iTTP episode at each site. A total of 583 patients experienced 719 iTTP episodes. The observed proportion of iTTP episodes during the winter was significantly greater than expected if equally distributed across seasons (28.5%, 205/719, 25.3%–31.9%; p = .03). Distance from the equator and mean temperature deviation both positively correlated with the proportion of iTTP episodes during winter. Acute iTTP episodes were associated with the winter season and colder temperatures, with a second peak during summer. Occurrence during winter was most pronounced at sites further from the equator and/or with greater annual temperature deviations. Understanding the etiologies underlying seasonal patterns of disease may assist in discovery and development of future preventative therapies and inform models for resource utilization.
Synthesis of Optically Active Cyclam and Its Transformations
Authors: Yoshida Kazuhiro , Miwa Yuya , Tojima Yakumo , Takahashi Miyuki , Shishido Daichi 
Published: August 2024

AbstractCyclam is a well‐known example of a polyaza macrocycle. However, there are few reports of its optically active versions. In this study, we synthesized highly symmetric optically active cyclam (S,S,S,S)‐5,7,12,14‐tetraphenyl‐1,4,8,11‐tetraazacyclotetradecane, which has four phenyl groups on the cyclam skeleton, and derivatized it in various ways. We were able to synthesize a chiral Cu complex, an N‐ethyl derivative, and a dithiourea from this optically active cyclam. The structures of the chiral Cu complex and dithiourea were verified by single‐crystal X‐ray diffraction analysis.
A Simple and Facile Conjugate Addition of Cyclic and Acyclic 1,3‐Diketones to β‐Nitrostyrenes
Authors: Mistry Dharti , Macwan Nikunjana Benjamin , Malvi Payal , Lenin Dandamudi V. 
Published: August 2024

AbstractA simple synthesis of 3‐hydroxy‐2‐(2‐nitro‐1‐arylethyl)cyclohex‐2‐en‐1‐ones, 3‐hydroxy‐5,5‐dimethyl‐2‐(2‐nitro‐1‐arylethyl)cyclohex‐2‐en‐1‐ones and 4‐hydroxy‐3‐(2‐nitro‐1‐arylethyl)pent‐3‐en‐2‐ones via conjugate addition of cyclic 1,3‐diketones, 1,3‐cyclohexanedione and 5,5‐dimethyl‐1,3‐cyclohexanedione and acyclic 1,3‐diketone, pentane‐2,4‐dione to β‐Nitrostyrenes were reported. This methodology is pleasing with reliability and scalability with gram scale products that can be synthesized.
How we achieved “the most significant Australian child welfare reform in a generation”
Authors: McDonald Paul 
Published: August 2024

AbstractIn Australia, on any given day, about 45,000 children and youth aged 0–17 (about 1 per cent of Australian youth) are in the care of the state, often cared for through delegation‐funded child welfare organisations. Many of these children are in out‐of‐home care of such organisations for brief periods of time, but a substantial number remain in care until their mandatory emancipation. About 3600 youth a year are obliged to leave care at 18 years of age, due to child protection orders ending before their 18th birthday. Many advocates in the field, including former youth in out‐of‐home care represented in the CREATE Foundation, believe that this is much too young to be out on their own. Founded in 2016, Home Stretch is a national advocacy campaign to extend the leaving care age for young people in out‐of‐home care from 18 to 21 years in all Australian jurisdictions. Prior to the Home Stretch movement, no Australian state, territory or federal government (with the partial exception of the ACT) had indicated any action, interest or desire to extending its services to children in state care past 18 years. Yet, extended care in varying forms has been found recommended in various government enquiries over the past several decades. Seven years after the Home Stretch launch, extended care is now offered in all eight Australian jurisdictions, and at last count, over 4200 young people are in extended care arrangements to 21 years across the country. This is a remarkable social policy about face by the Government in a relatively short space of time. In this article, we describe the advocacy strategy employed.
Digital welfare‐to‐work in the global south: A case of Indonesian pre‐employment card program
Authors: Nguyen Phuc , Considine Mark , Putra Fadillah , Sanusi Anwar 
Published: August 2024

AbstractThe worldwide movement toward digitisation in public service delivery presents a range of opportunities and risks. The potential benefits include improved efficiency, more consistent service delivery decisions and enhanced responsiveness to citizens' demand. The potential risks range from challenges in data use and privacy, to uneven service accessibility and the costly ICT investment required for digitisation. Researchers have begun to assess this important movement and its impacts. There remains a lack of in‐depth understanding of digitisation of public service delivery in developing countries. We aim to address that gap by examining a fully online welfare‐to‐work programme in a developing country, that is Indonesia's Pre‐employment Card Program. Using data collected from semi‐structured interviews with policymakers and service providers, we found evidence that digitalisation contributed to the programme's efficiency and effectiveness via, for example, automated registration processes and quick and revisable rollout. Its implementation however was not without challenges such as a digital divide among users and some technical problems. Indonesia's experiences with this fully digital programme suggest that a developing country, despite limited financial and administrative capacity, can embark on the digitalisation journey to improve their public service provision, even during the time of crisis.
A comprehensive view on the fisetin impact on colorectal cancer in animal models: Focusing on cellular and molecular mechanisms
Authors: Zamanian Mohammad Yasin , Taheri Niloofar , Ramadan Montather F. , Mustafa Yasser Fakri , Alkhayyat Safa , Sergeevna Klunko Nataliya , Alsaab Hashem O. , Hjazi Ahmed , Molavi Vasei Farnoosh , Daneshvar Siamak 
Published: August 2024

AbstractFlavonoids, including fisetin, have been linked to a reduced risk of colorectal cancer (CRC) and have potential therapeutic applications for the condition. Fisetin, a natural flavonoid found in various fruits and vegetables, has shown promise in managing CRC due to its diverse biological activities. It has been found to influence key cell signaling pathways related to inflammation, angiogenesis, apoptosis, and transcription factors. The results of this study demonstrate that fisetin induces colon cancer cell apoptosis through multiple mechanisms. It impacts the p53 pathway, leading to increased levels of p53 and decreased levels of murine double minute 2, contributing to apoptosis induction. Fisetin also triggers the release of important components in the apoptotic process, such as second mitochondria‐derived activator of caspase/direct inhibitor of apoptosis‐binding protein with low pI and cytochrome c. Furthermore, fisetin inhibits the cyclooxygenase‐2 and wingless‐related integration site (Wnt)/epidermal growth factor receptor/nuclear factor kappa B signaling pathways, reducing Wnt target gene expression and hindering colony formation. It achieves this by regulating the activities of cyclin‐dependent kinase 2 and cyclin‐dependent kinase 4, reducing retinoblastoma protein phosphorylation, decreasing cyclin E levels, and increasing p21 levels, ultimately influencing E2 promoter binding factor 1 and cell division cycle 2 (CDC2) protein levels. Additionally, fisetin exhibits various effects on CRC cells, including inhibiting the phosphorylation of Y‐box binding protein 1 and ribosomal S6 kinase, promoting the phosphorylation of extracellular signal‐regulated kinase 1/2, and disrupting the repair process of DNA double‐strand breaks. Moreover, fisetin serves as an adjunct therapy for the prevention and treatment of phosphatidylinositol‐4,5‐bisphosphate 3‐kinase catalytic subunit α (PIK3CA)‐mutant CRC, resulting in a reduction in phosphatidylinositol‐3 kinase (PI3K) expression, Ak strain transforming phosphorylation, mTOR activity, and downstream target proteins in CRC cells with a PIK3CA mutation. These findings highlight the multifaceted potential of fisetin in managing CRC and position it as a promising candidate for future therapy development.
Mechanistically Different Mechanochromophores Enable Calibration and Validation of Molecular Forces in Glassy Polymers and Elastomeric Networks
Authors: Hertel Raphael , Raisch Maximilian , Walter Michael , Reiter Günter , Sommer Michael 
Published: August 2024

AbstractSterically distorted donor‐acceptor π‐systems, termed DA springs, can be progressively planarized under mechanical load causing a bathochromic shift of the photoluminescence (PL) spectrum. By combining theory and experiment, we here use a simple linear force calibration for two different conformational mechanochromophores to determine molecular forces in polymers from the mechanochromic shift in PL wavelength during multiple uniaxial tensile tests. Two systems are used, i) a highly entangled linear glassy polyphenylene and ii) a covalent elastomeric polydimethylsiloxane network. The mean forces estimated by this method are validated using known threshold forces for the mechanochemical ring‐opening reactions of two different spiropyran force probes. The agreement between both approaches underlines that these DA springs provide the unique opportunity for the online monitoring of local molecular forces present in diverse polymer matrices.
Extending the π‐Conjugation of a Donor‐Acceptor Covalent Organic Framework for High‐Rate and High‐Capacity Lithium‐Ion Batteries
Authors: Li Chengqiu , Yu Ao , Zhao WenKai , Long Guankui , Zhang Qichun , Mei Shilin , Yao Chang‐Jiang 
Published: August 2024

AbstractRealizing high‐rate and high‐capacity features of Lihium‐organic batteries is essential for their practical use but remains a big challenge, which is due to the instrinsic poor conductivity, limited redox kinetics and low utility of organic electrode mateials. This work presents a well‐designed donor‐acceptor Covalent Organic Framework (COFs) with extended conjugation, mesoscale porosity, and dual redox‐active centers to promote fast charge transfer and multi‐electron processes. As anticipated, the prepared cathode with benzo [1,2‐b:3,4‐b′:5,6‐b′′] trithiophene (BTT) as p‐type and pyrene‐4,5,9,10‐tetraone (PTO) as n‐type material (BTT‐PTO‐COF) delivers impressive specific capacity (218 mAh g−1 at 0.2 A g−1 in ether‐based electrolyte and 275 mAh g−1 at 0.2 A g−1 in carbonate‐based electrolyte) and outstanding rate capability (79 mAh g−1 at 50 A g−1 in ether‐based electrolyte and 124 mAh g−1 at 10 A g−1 in carbonate‐based electrolyte). In addition, the potential of BTT‐PTO‐COF electrode for prototype batteries has been demonstrated by full cells of dual‐ion (FDIBs), which attain comparable electrochemical performances to the half cells. Moreover, mechanism studies combining ex situ characterization and theoratical calculations reveal the efficient dual‐ion storage process and facile charge transfer of BTT‐PTO‐COF. This work not only expands the diversity of redox‐active COFs but also provide concept of structure design for high‐rate and high‐capacity organic electrodes.
Highly Selective CO2 Electroreduction to Multi‐Carbon Alcohols via Amine Modified Copper Nanoparticles at Acidic Conditions
Authors: Wu Yahui , Chen Chunjun , Liu Shoujie , Qian Qingli , Zhu Qinggong , Feng Rongjuan , Jing Lihong , Kang Xinchen , Sun Xiaofu , Han Buxing 
Published: August 2024

AbstractElectroreduction of CO2 into multi‐carbon (C2+) products (e.g. C2+ alcohols) offers a promising way for CO2 utilization. Use of strong alkaline electrolytes is favorable to producing C2+ products. However, CO2 can react with hydroxide to form carbonate/bicarbonate, which results in low carbon utilization efficiency and poor stability. Using acidic electrolyte is an efficient way to solve the problems, but it is a challenge to achieve high selectivity of C2+ products. Here we report that the amine modified copper nanoparticles exhibit high selectivity of C2+ products and carbon utilization at acidic condition. The Faradaic efficiency (FE) of C2+ products reach up to 81.8 % at acidic media (pH=2) with a total current density of 410 mA cm−2 over n‐butylamine modified Cu. Especially the FE of C2+ alcohols is 52.6 %, which is higher than those reported for CO2 electroreduction at acidic condition. In addition, the single‐pass carbon efficiency towards C2+ production reach up to 60 %. Detailed studies demonstrate that the amine molecule on the surface of Cu cannot only enhance the formation, adsorption and coverage of *CO, but also provide a hydrophobic environment, which result in the high selectivity of C2+ alcohols at acidic condition.
Syntheses of Tungsten Imido Cyclohexylidene Complexes Using Perfluoro‐t‐Butanol or Hexafluoro‐t‐Butanol as Acids
Authors: Maji Milan , Riedel René , Schrock Richard R. , Conley Matthew P. , Carta Veronica 
Published: August 2024

AbstractThe fluorinated alcohols, (CF3)3COH (RF9OH) and (CF3)2MeCOH (RF6OH), react with W(NR)2Cy2 (Cy=Cyclohexyl; R=2,6‐diisopropylphenyl or 1‐adamantyl) in C6D6 at 55 °C to give cyclohexylidene complexes. Traditional routes to terminal alkylidene complexes (neopentylidene or neophylidene) have used either triflic acid or HCl (rarely), but relatively weak fluorinated acids are sufficient and active bisalkoxide catalysts are therefore prepared directly. An α hydrogen abstraction reaction to give a cyclohexylidene complex from a biscyclohexyl complex appears to be as facile as α hydrogen abstraction to give a neopentylidene or neophylidene ligand, but isomerization of a cyclohexene formed through β hydrogen abstraction is also a possibility. The ORF9 ligands can be replaced readily with dimethylpyrrolide (Me2Pyr) or other more basic alkoxides. Single crystal X‐ray studies were carried out on W(NAr)2Cy2, W(NAr)(ORF9)2(C6H10)(ArNH2), W(NAr)(ORF6)2(C6H10)(ArNH2), W(NAd)(ORF9)2(C6H10)(AdNH2), W(NAr)(O‐i‐PrF6)3Cy, and W(NAd)(η1‐Me2Pyr)2(C6H10) (C6H10=cyclohexylidene).
Fabrication of Scalable Covalent Organic Framework Membrane‐based Electrolytes for Solid‐State Lithium Metal Batteries
Authors: Liu Tongtong , Zhong Yuan , Yan Zhiwei , He Boying , Liu Tao , Ling Zhiyi , Li Bocong , Liu Xin , Zhu Jialiang , Jiang Lingyi , Gao Xiangyu , Zhang Rongchun , Zhang Jianrui , Xu Bingqing , Zhang Gen 
Published: August 2024

AbstractThe conventional covalent organic framework (COF)‐based electrolytes with tailored ionic conducting behaviors are typically fabricated in the powder morphology, requiring further compaction procedures to operate as solid electrolyte tablets, which hinders the large‐scale manufacturing of COF materials. In this study, we present a feasible electrospinning strategy to prepare scalable, self‐supporting COF membranes (COMs) that feature a rigid COF skeleton bonded with flexible, lithiophilic polyethylene glycol (PEG) chains, forming an ion conduction network for Li+ transport. The resulting PEG‐COM electrolytes exhibit enhanced dendrite inhibition and high ionic conductivity of 0.153 mS cm−1 at 30 °C. The improved Li+ conduction in PEG‐COM electrolytes stems from the loose ion pairing in the structure and the production of higher free Li+ content, as confirmed by solid‐state 7Li NMR experiments. These changes in the local microenvironment of Li+ facilitate its directional movement within the COM pores. Consequently, solid‐state symmetrical Li|Li, Li|LFP, and pouch cells demonstrate excellent electrochemical performance at 60 °C. This strategy offers a universal approach for constructing scalable COM‐based electrolytes, thereby broadening the practical applications of COFs in solid‐state lithium metal batteries.
Magnetically Induced Amination of Alcohols Using MNi@Cu (M=Fe, Co) Nanoparticles as Catalysts
Authors: Varela‐Izquierdo Víctor , Mustieles‐Marín Irene , Fazzini Pier‐Francesco , Mencía Gabriel , Guelen Simon , Rachet Rabih , Chaudret Bruno 
Published: August 2024

AbstractThe synthesis of tertiary amines from alcohols (i.e. heptanol, dodecanol, cyclohexanol, benzylalcohol) and secondary amines (Me2NH (DMA), nPr2NH, nBu2NH) has been achieved in one step using trimetallic nanoparticles (NPs) displaying a magnetic core (Co4Ni6 and Fe3Ni7) and a Cu shell as both catalysts and heating agent in the presence of an alternating magnetic field. This methodology limits the redistribution reactions occurring on amines at high temperature leading to both much higher conversion and selectivity in the absence of solvent than usually observed using conventional heating. Moreover, Co4Ni6@Cu NPs were found moisture resistant, thereby allowing for performing the reaction with commercial DMA in water (40 % wt) with again high conversion and selectivity.
Lighting Up Bispyrene‐Functionalized Chiral Molecular Muscles with Switchable Circularly Polarized Excimer Emissions
Authors: Li Xue , Xu Wei‐Tao , Xu Xiao‐Qin , Wang Yu , Wang Xu‐Qing , Yang Hai‐Bo , Wang Wei 
Published: August 2024

AbstractAiming at the further extension of the application scope of traditional molecular muscles, a novel bispyrene‐functionalized chiral molecular [c2]daisy chain was designed and synthesized. Taking advantage of the unique dimeric interlocked structure of molecular [c2]daisy chain, the resultant chiral molecular muscle emits strong circularly polarized luminescence (CPL) attributed to the pyrene excimer with a high dissymmetry factor (glum) value of 0.010. More importantly, along with the solvent‐ or anion‐ induced motions of the chiral molecular muscle, the precise regulation of the pyrene stacking within its skeleton results in the switching towards either “inversed” state with sign inversion and larger glum values or “down” state with maintained handedness and smaller glum values, making it a novel multistate CPL switch. As the first example of chiral molecular muscle‐based CPL switch, this proof‐of‐concept study not only successfully widens the application scopes of molecular muscles, but also provides a promising platform for the construction of novel smart chiral luminescent materials for practical applications.
Photocatalytic Synthesis of Glycine from Methanol and Nitrate
Authors: Li Peifeng , Zhao Wanghui , Wang Kaixuan , Wang Tao , Zhang Biaobiao 
Published: August 2024

AbstractPhotocatalytic utilization of methanol and nitrate as carbon and nitrogen sources for the direct synthesis of amino acids could provide a sustainable way for the valorization of green “liquid sunlight” and nitrate waste. In this study, we develop an efficient photochemical method to synthesize glycine directly from methanol and nitrate, which cascades the C−C coupling to form glycol, nitrate reduction to NH3, and finally C−N coupling to generate glycine. Interestingly, the involved photocatalytic tandem reactions show a synergistic effect, in which the presence of nitrate is the dominant factor to enable the overall reaction and reach high synthetic efficiency. Ba2+−TiO2 nanoparticles are confirmed as a feasible and efficient catalyst system for the photosynthesis of glycine with a remarkable glycine photosynthesis rate of 870 μmol gcat−1 h−1 under optimal conditions. This work establishes a novel catalytic system for amino acid synthesis from methanol and nitrate under mild conditions. These results also allow us to further suppose the formation pathways of amino acids on the primitive earth, as an extension to proposals based on the Miller‐Urey experiments.