bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Model Pembelajaran Siklus Belajar 5E (Learning Cycle 5E) Terhadap Keterampilan Proses Sains Siswa Pada Pembelajaran Kimia Kelas X SMK Negeri 1 Nganjuk Tahun Pelajaran 2021/2022
Authors: Winggi Kaesta Uri 
Published: August 2024

Tujuan dari penelitian ini adalah 1) mengetahui penerapan model pembelajaran konvensional terhadap keterampilan proses sains siswa, 2) mengetahui penerapan model pembelajaran Siklus Belajar 5E terhadap keterampilan proses sains siswa, 3) mengetahui adanya perbedaan antara penerapan model pembelajaran konvensional dengan model pembelajaran Siklus Belajar 5E terhadap keterampilan proses sains siswa pada pembelajaran kimia kelas X SMKN 1 Nganjuk tahun pelajaran 2021/2022. Penelitian ini merupakan penelitian eksperimen kuantitatif menggunakan Posttest-Only Control Design. Populasi pada penelitian ini adalah siswa kelas X SMKN 1 Nganjuk yang berjumlah 538 siswa. Pemilihan sampel dilakukan dengan teknik purposive sampling yaitu kelas X-MM-1 sebagai kelas eksperimen dan kelas X-MM-2 sebagai kelas kontrol. Teknik pengumpulan data menggunakan tes berupa tes tertulis dengan soal uraian dan dokumentasi. Instrumen pada penelitian ini adalah tes berupa Posttest soal uraian. Teknik analisis data yang digunakan adalah analisis statistika deskriptif dan statistika inferensial. Berdasarkan hasil Posttest diperoleh rata-rata nilai kelas eksperimen 84,11 sedangkan kelas kontrol 67,83. Berdasarkan hasil uji t diperoleh nilai signifikansi Sig.(2-tailed) 0,000 yang artinya Sig.(2-tailed) < 0,05. Selain itu juga dilakukan uji hipotesis dengan menggunakan thitung dan ttabel didapatkan ttabel yaitu 1,66691 dengan thitung 6,685maka thitung (6,685) > ttabel (1,6691). Berdasarkan kedua uji yang dilakukan maka H0 ditolak dan Ha diterima. Dari hasil tersebut dapat disimpulkan ada perbedaan antara model pembelajaran konvensional dengan model pembelajaran Siklus Belajar 5E terhadap keterampilan proses sains siswa pada pembelajaran kimia. Perbedaan tersebut menunjukkan keterampilan proses sains siswa pada pembelajaran kimia dengan menggunakan model pembelajaran Siklus Belajar 5E lebih baik daripada menggunakan model pembelajaran konvensional.
The contribution of energy systems during 15-second sprint exercise in athletes of different sports specializations
Authors: Archacki Damian , Zieliński Jacek , Pospieszna Barbara , Włodarczyk Michał , Kusy Krzysztof 
Published: August 2024

Background
Long-term adaptations and ongoing training seem to modify the energy system contribution in highly trained individuals. We aimed to compare the energy metabolism profile during sprint exercise in athletes of different specialties.

Methods
Endurance (n = 17, 20.3 ± 6.0 yrs), speed-power (n = 14, 20.3 ± 2.5 yrs), and mixed (n = 19, 23.4 ± 4.8 yrs) athletes performed adapted 15-second all-out test before and after a general preparation training period. The contribution of phosphagen, glycolytic, and aerobic systems was calculated using the three-component PCr-LA-O2 method.

Results
Between-group differences were observed in the contribution of energy systems in the first and second examinations. The proportions were 47:41:12 in endurance, 35:57:8 in team sports, and 45:48:7 in speed-power athletes. Endurance athletes differed in the phosphagen (p < 0.001) and glycolytic systems (p = 0.006) from team sports and in the aerobic system from speed-power athletes (p = 0.003). No substantial shifts were observed after the general preparatory phase, except a decrease in aerobic energy contribution in team sports athletes (p = 0.048).

Conclusion
Sports specialization and metabolic profile influence energy system contribution during sprint exercise. Highly trained athletes show a stable energy profile during the general preparation phase, indicative of long-term adaptation, rather than immediate training effects.
Long-term passage impacts human dental pulp stem cell activities and cell response to drug addition in vitro
Authors: Patntirapong Somying , Khankhow Juthaluck , Julamorn Sikarin 
Published: August 2024

Background
Dental pulp stem cells (DPSCs) possess mesenchymal stem cell characteristics and have potential for cell-based therapy. Cell expansion is essential to achieve sufficient cell numbers. However, continuous cell replication causes cell aging in vitro, which usually accompanies and potentially affect DPSC characteristics and activities. Continuous passaging could alter susceptibility to external factors such as drug treatment. Therefore, this study sought to investigate potential outcome of in vitro passaging on DPSC morphology and activities in the absence or presence of external factor.

Methods
Human DPSCs were subcultured until reaching early passages (P5), extended passages (P10), and late passages (P15). Cells were evaluated and compared for cell and nuclear morphologies, cell adhesion, proliferative capacity, alkaline phosphatase (ALP) activity, and gene expressions in the absence or presence of external factor. Alendronate (ALN) drug treatment was used as an external factor.

Results
Continuous passaging of DPSCs gradually lost their normal spindle shape and increased in cell and nuclear sizes. DPSCs were vulnerable to ALN. The size and shape were altered, leading to morphological abnormality and inhomogeneity. Long-term culture and ALN interfered with cell adhesion. DPSCs were able to proliferate irrespective of cell passages but the rate of cell proliferation in late passages was slower. ALN at moderate dose inhibited cell growth. ALN caused reduction of ALP activity in early passage. In contrast, extended passage responded differently to ALN by increasing ALP activity. Late passage showed higher collagen but lower osteocalcin gene expressions compared with early passage in the presence of ALN.

Conclusion
An increase in passage number played critical role in cell morphology and activities as well as responses to the addition of an external factor. The effects of cell passage should be considered when used in basic science research and clinical applications.
Ameliorative effect of indole acetic acid and naphthalene acetic acid on some biochemical parameters of soybean exposed to lead toxicity
Authors: Ailenokhuoria Bukola Victoria , Charles. O. Olaiya  
Published: August 2024

Lead (Pb) is a potential pollutant that readily accumulates in soils and sediments widely occurred as a result of human, agricultural and industrial activities. IAA and NAA belongs to plant hormone auxin that promote plants growth. The effects of lead (Pb) phytotoxicity include stunted growth, chlorosis, blackening of the root systems, alteration in water and nutritional status of plants, inhibition of enzyme activities and so on. This study therefore aim at examining possible ameliorative effects of Indole acetic acid( IAA) and Naphthalene acetic acid (NAA) on some biochemical parameters (photosynthetic pigments, mineral elements and antioxidant enzymes) of soybean exposed to lead( Pb) toxicity.
One thousand (1000)mg/L of PbNO3 was applied to 5kg of soil in a polythene bag It was allow to acclimatize for 2 weeks after which the seed were sown in the soil. Fourty (40)mg/L, 80 mg/L and 120mg/L each of IAA and NAA were prepared and applied by foliar method after 5 weeks of planting. The plants were harvested after 7 weeks and was partitioned into root, stem and leaf for analysis. The results showed that the level of chlorophyll a, b and carotenoid, mineral elements and antioxidant enzymes significantly increased (P˂0.05) in the root, stem and leaf of soybean treated with different concentration of Indole acetic acid (IAA) and Naphthalene acetic acid (NAA) as compared with the control (C+ve). All bioregulators (IAA and NAA) concentrations significantly decreased (P˂0.05) in the level of Pb2+ (except 40mg/L IAA in the root and leaf while all concentration have significant effects in the stem) and also all concentration of (IAA and NAA) significantly increased (P˂0.05) in the level of biochemical parameters to different extent as compared to control(C+ve). These results shows that Indole acetic acid (IAA) and Naphthalene acetic acid ( NAA) could ameliorate the Pb toxicity and therefore will be of relevance to agricultural producers .
Climate change causes, impacts, action plan, and human health in India.
Authors: Sahdev  , Sahu Tushar 
Published: August 2024

Climate change has become a big problem for India and the whole world today. Climate change is having an impact on humans as well as the environment. The reason for this is anthropogenic and natural. Human beings are suffering from diseases due to increases in temperature due to climate change, an increase in harmful gases, the greenhouse effect, etc. The problem of climate change has arisen. Due to climate change, problems with water, food, drought, economy, health, etc. have arisen. Globally, conferences are being held every year to tackle climate change. Countries from all over the world are present at this conference and are working to deal with climate change. India is moving ahead with many plans to deal with climate change. The world is working to reduce CO2, CH4, N2O, and temperatures. Research is being made to tackle climate change. Climate change has been discussed in detail in this review.
A comparative study of acid water treatment by grasses
Authors: Soni Ranjeeta 
Published: August 2024

Alkaline water and other alkaline products have gained popularity in recent years, becoming a new health trend alkaline drinks. Acidic environments in the body cause several chronic illnesses, which they claim could not persist in an alkaline environment. The thinking behind this is that drinking alkaline water helps the body itself to become more alkaline, which will treat a number of illnesses, including cancer. In general, alkaline water tends to be more alkaline because it has minerals and electrolytes in it. Due to this, drinking this water after a workout or while sick may help keep minerals and electrolytes balanced and prevent dehydration. Medicinal plants are rich in several potential drugs and it carries healthier and harmless alternate to synthetic system of drugs. Plant doob/ bermuda grass (Cynodon dactylon) family (Graminae/Poaceae) is one of them. Doob grass is a perennial grass circulated all over the world, and particularly it is native to the high temperate and tropical regions.. It has various medicinal values and it is used in the treatment of various types of diseases in the form of various dosage forms like powder, paste or extracts. The plant of C. dactylon has a variety of biological activities like antiviral, antibacterial, antimicrobial and specially wound healing properties (Virmani R et al. Hidden Potential of Doob Grass- An Indian Traditional Drug. Res Pharm Health Sci.2018; 4(3). Barley grass (Hordeum vulgare) family (Poaceae) and doob grass taken for study to reduce the acidity from water.
Designing an interior space of residence using recycling and sustainable materials and reduce the impact of hazardous materials
Authors: Rupasinghe Kasun Tharaka 
Published: August 2024

Recycling materials and sustainable materials are two major aspects in Architecture. And when it comes to interior design this can affect more to the human being as well as the indoor environment. It’s not just we can use materials in cheaper ways that we generate less pollution and produce good air quality to have well being life cycle around you. The basic output of this project is to identify and study the hazardousness of materials and to reduce its impact and to give solutions and alternatives to use them in a healthy way. The new design era has given energy to the design perspective, many of the modern designs has its own uniqueness, basically including shapes, forms and specially the selection of materials. And as designers we all must have a concern of its nature and how it effect to the health and also to increase the indoor air quality of the particular area. And as one of my main focuses of the project is to use recycle materials you need to have an idea about what kind of materials can be used in addition to the other perspective of the design. Hazardous of the materials has its own properties which can do a real harm and even cost the lives. So as this comes as a part of mine main objective of the project this study and the exercises are depend on the study of those materials and giving them better solutions with reducing the effect on the nature and the environment.
Assessment on fishery resources in Kottaipattinam coast, Palk Bay, Southeast Coast of India
Authors: Sathiya C. , Sesh Serebiah J. , Stella Chelladurai 
Published: August 2024

The present study dealt with fishery resources in Kottaipattinam coast. The study was carried out for the period of one year from (April 2019 - March 2020) to assess the diversity and seasonal changes. 58 species belongs to 19 order were recorded in the present study. Among, nineteen species were collected from the order perciforms which showed highest species composition. Eight species were collected in the order Carangiforms noticed to be second dominant order for species composition. Other orders showed least representations. Fifty three species were landed during post monsoon season followed by pre monsoon (50 Nos) and monsoon and summer seasons represented by equal numbers as 48. It was clearly found that the life history of many fishes in Palk bay are adapted to the seasonal changes. Hence it would be useful to design the capture strategies especially in Palk bay for sustainable resource utilization.
Phytochemical analysis and in vitro antioxidant activity of Solanum tuberosum peel using High-Resolution Liquid Chromatography Mass Spectrometry (HR-LCMS) and FTIR *Deo S. K. and Sakhale B.K.
Authors: Deo Shrutika K , B K Sakhale , B K Sakhale 
Published: August 2024

Potato peel (PP) is high in bioactive compounds and has an immense important in the nutraceutical sector, a wide spectrum of bioactive secondary metabolites produced by potato peel can be used to build novel medications and functional foods. It has been demonstrated that complex bioactive chemicals must be analyzed using analytical methods such as HR-LCMS. The current project's goal was to study the bioactive metabolites found in methanolic extract of potato peel (MEPP) using total pheolic (TPC), flavanoids (TFC), in vitro anti oxidant activity, HR-LCMS and FTIR. Using Q-TOF LC/MS and Agilent MassHunter Profiler software to investigate the bioactive components of PP, researchers discovered 28 bioactive chemicals such as 4,7-Dihydroxy-2H-1-benzopyran-2-one.4-Coumaroyl-2-hydroxyputrescine,6,8dihydroxypurine,6'-methoxypolygoacetophenoside, Alloxanthin, Butyl 3-O-caffeoylquinate, Chlorogenic acid, Cularicine, Feruloylputrescine, Feruloylputrescine, Feruloylputrescine, Feruloylputrescine, Feruloylput, Quinic acid, Gerberinol, Grossamide, Quercetagetin that have anticancer, antimicrobial, anti-inflammatory, and antitumor activity. The current findings of this study reveal the presence of significant phytocompounds in PP and are valuable for future research into developing functional foods from PP to avoid a variety of diseases. Current study is aimed at discovering all-natural treatments for a wide range of ailments and conditions.
Keywords: Potato peel, HR-LCMS, FTIR, Bioactive compounds, TPC, TFC
Antifungal Activity of Some Plant Extracts on Alternaria Burnsii: The Causal Agent of Alternaria Blight of Cumin
Authors: Jagani Bhavna , Parmar Minaxi , Patel Vallabh bhai , Vishwakarma Nutan Prakash 
Published: August 2024

Cumin is a vital seed spice crop in India. The most dreaded disease in the cumin crop is Alternaria blight, caused by Alternaria burnsii. It is a significant production constraint for cultivating the cumin crop in Gujarat as in India. Eight different plant species were utilized for the eco-friendly management of this disease. The experiment on managing Alternaria blight of cumin was conducted at Atmiya University, Rajkot. Crude plant extracts were prepared in water, acetone, and cow urine as solvents at different concentrations (5%, 10%, and 15%). The poisoned food technique determined the in vitro antifungal activity of these plant extracts. Based on in vitro studies, all the plants exhibited significant antifungal activity. During the research work, it was found that the highest inhibition was recorded for Azadirachta indica (78.15%) extract prepared in acetone, followed by Mimuspos elengi (67.75%) extract prepared in cow urine at 15% concentration (at p≤0.01). The lowest inhibition was recorded for Aloe barbadensis miller (40.24%), and Annona reticulata (43.48%) extract prepared in water at 15% concentration.
Homoeopathic treatment on diabetic distal symmetric polyneuropathy [ddsp]: a systematic review.
Authors: Samdani Dr. Simran , Nadgauda Dr Sameer 
Published: August 2024

Background: An epidemic of the disorders/ complications is paralleling the global epidemics of prediabetes and diabetes. The most frequent complication is neuropathy, of which distal symmetric polyneuropathy (DDSP) is very common. Diabetic neuropathy is characterised by pain and significant morbidity, as well as a loss of sensory function that begins distantly in the lower extremities. At least 50% of people with diabetes eventually develop diabetic neuropathy. In patients with type 1 diabetes mellitus, glucose control effectively slows the progression of diabetic neuropathy; however, the effects are less pronounced in patients with type 2 diabetes mellitus. Material and Methods: To locate clinical research publications, a computerised literature search was conducted. A thorough search of PubMed, Medline, Google Scholar, ScienceDirect, and the Thieme-E-journal of homoeopathy was done. This review only included clinical studies that involved humans. Pilot research, animal experiments were excluded. All prospective observational clinical research studies that were randomised, double-blind, and placebo-controlled were included. Conclusion: This systematic review concluded that homeopathic medicines are safe and effective in management of Diabetic Distal Symmetric Polyneuropathy (DDSP). But more randomized placebo controlled studies should be conducted to strengthen the available evidence.
Conversion of 2‐Iodobiaryls into 2,2′‐Diiodobiaryls via Oxidation‐Iodination Sequences: A Versatile Route to Ladder‐Type Heterofluorenes
Authors: Wu Bin , Yoshikai Naohiko 
Published: June 2015

AbstractEven though 2,2′‐diiodo‐ and 2,2′‐dibromobiaryls represent accomplished precursors for heterofluorenes and other extended π‐conjugated systems, their preparation still remains nontrivial when structural diversity of the biaryl backbone is required. Herein, we report a convenient method for the preparation of various 2,2′‐diiodobiaryls from 2‐iodobiaryls via cyclic diaryliodonium intermediates. An iodinative ring‐opening of the diaryliodonium salts, mediated by a copper/diamine catalyst system, is able to afford the corresponding 2,2′‐diiodobiaryls under mild conditions. The versatility of this two‐step approach is demonstrated by the preparation of hitherto unexplored tetraiodoteraryls and their conversion into ladder‐type π‐conjugated systems.
Minimal clinically important differences in the Edmonton Symptom Assessment Scale in cancer patients: A prospective, multicenter study
Authors: Hui David , Shamieh Omar , Paiva Carlos Eduardo , Perez‐Cruz Pedro Emilio , Kwon Jung Hye , Muckaden Mary Ann , Park Minjeong , Yennu Sriram , Kang Jung Hun , Bruera Eduardo 
Published: June 2015

BACKGROUNDThe Edmonton Symptom Assessment Scale (ESAS) is widely used for symptom assessment in clinical and research settings. A sensitivity‐specificity approach was used to identify the minimal clinically important difference (MCID) for improvement and deterioration for each of the 10 ESAS symptoms.METHODSThis multicenter, prospective, longitudinal study enrolled patients with advanced cancer. ESAS was measured at the first clinic visit and at a second visit 3 weeks later. For each symptom, the Patient's Global Impression (“better,” “about the same,” or “worse”) was assessed at the second visit as the external criterion, and the MCID was determined on the basis of the optimal cutoff in the receiver operating characteristic (ROC) curve. A sensitivity analysis was conducted through the estimation of MCIDs with other approaches.RESULTSFor the 796 participants, the median duration between the 2 study visits was 21 days (interquartile range, 18‐28 days). The area under the ROC curve varied from 0.70 to 0.87, and this suggested good responsiveness. For all 10 symptoms, the optimal cutoff was ≥1 point for improvement and ≤–1 point for deterioration, with sensitivities of 59% to 85% and specificities of 69% to 85%. With other approaches, the MCIDs varied from 0.8 to 2.2 for improvement and from −0.8 to −2.3 for deterioration in the within‐patient analysis, from 1.2 to 1.6 with the one‐half standard deviation approach, and from 1.3 to 1.7 with the standard error of measurement approach.CONCLUSIONSESAS was responsive to change. The optimal cutoffs were ≥1 point for improvement and ≤–1 point for deterioration for each of the 10 symptoms. Our findings have implications for sample size calculations and response determination. Cancer 2015;121:3027–3035. © 2015 American Cancer Society.
Risk factors for lung function decline in a large cohort of young cystic fibrosis patients
Authors: Cogen Jonathan , Emerson Julia , Sanders Don B. , Ren Clement , Schechter Michael S. , Gibson Ronald L. , Morgan Wayne , Rosenfeld Margaret ,   for the EPIC Study Group
Published: June 2015

SummaryObjectiveTo identify novel risk factors and corroborate previously identified risk factors for mean annual decline in FEV1% predicted in a large, contemporary, United States cohort of young cystic fibrosis (CF) patients.MethodsRetrospective observational study of participants in the EPIC Observational Study, who were Pseudomonas‐negative and ≤12 years of age at enrollment in 2004–2006. The associations between potential demographic, clinical, and environmental risk factors evaluated during the baseline year and subsequent mean annual decline in FEV1 percent predicted were evaluated using generalized estimating equations.ResultsThe 946 participants in the current analysis were followed for a mean of 6.2 (SD 1.3) years. Mean annual decline in FEV1% predicted was 1.01% (95%CI 0.85–1.17%). Children with one or no F508del mutations had a significantly smaller annual decline in FEV1 compared to F508del homozygotes. In a multivariable model, risk factors during the baseline year associated with a larger subsequent mean annual lung function decline included female gender, frequent or productive cough, low BMI (<66th percentile, median in the cohort), ≥1 pulmonary exacerbation, high FEV1 (≥115% predicted, in the top quartile), and respiratory culture positive for methicillin‐sensitive Staphylococcus aureus, methicillin‐resistant S. aureus, or Stenotrophomonas maltophilia.ConclusionsWe have identified a range of risk factors for FEV1 decline in a large cohort of young, CF patients who were Pa negative at enrollment, including novel as well as previously identified characteristics. These results could inform the design of a clinical trial in which rate of FEV1 decline is the primary endpoint and identify high‐risk groups that may benefit from closer monitoring. Pediatr Pulmonol. 2015; 50:763–770. © 2015 Wiley Periodicals, Inc.