bluuebunny/crossref_metadata_2025_split huggingface dataset:
Albanian Settlements in the Aegean Islands
Authors: Hasluck F. W. 
Published: October 2013

An investigation of the very scattered literature of the Greek islands, designed primarily to supplement Mr. Dawkins's researches on the dialects, has led me to unexpectedly interesting results touching the Albanian settlements, which may be worthy of independent publication.Besides printed sources I have consulted the Grand Insulaire of André Thevet (Paris, Bibl. Nat. MSS. Fr. 15, 453 (1586)) and the Isolarii of Antonio di Milo (B.M. (a) Julius, E. II (1587), (b) Add. MSS. 10,365 (1591)), and Francesco Lupazolo of Chios (B.M. Lansd. 792 (1638)).
Frankish Remains at Adalia
Authors: Hasluck F. W. 
Published: October 2013

The city of Adalia on the Caramanian coast, still a very fine example of a mediaeval walled town, has been thrice attempted by western arms and was for twelve years garrisoned by the French kings of Cyprus.It was taken by Gautier de Montbeliard early in the reign of Hugues I. Lusignan (1205–18) but hurriedly abandoned. The warlike Pierre I. captured it in 1361 and it was held till 1373, when his successor, Pierre II. surrendered it. Lastly the ‘Crusaders’ of Mocenigo's expedition in 1472 stormed and sacked the seaward quarter but were unable to make good their footing. The surviving Frankish monuments must be attributed to the second Cypriote period.
Risk factors associated with human papillomavirus infection status in a Korean cohort
Authors: LEE H. , LEE D.-H. , SONG Y.-M. , LEE K. , SUNG J. , KO G. 
Published: October 2013

SUMMARYBy surveying extensive epidemiological behavioural and sexual risk factors in a Korean twin cohort, risk factors for human papillomavirus (HPV) infection were investigated in South Korea. A total of 912 vaginal specimens were collected from the Healthy Twin Study, consisting of twins and their families. A range of epidemiological, behavioural, and sexual activity characteristics were evaluated using multivariate logistic regression analyses of family and twin relationships, adjusted to elucidate the risk factors for HPV infection. Of the various epidemiological characteristics, the possibility of extramarital affairs [odds ratio (OR) 2·48, 95% confidence interval (CI) 1·02–6·02] significantly increased the prevalence of HPV infection. Our multivariate regression analysis indicated that oral contraceptive use (OR 40·64, 95% CI 0·99–1670·7) and history of sexually transmitted disease (OR 2·56, 95% CI 0·93–7·10) were strongly associated with an increase in HPV infection. On the other hand, more frequent vaginal douching (OR 0·32, 95% CI 0·13–0·77) significantly decreased the prevalence of HPV infection. Our results suggested that HPV infection is associated with both biological and behavioural factors.
Persistence of measles neutralizing antibody related to vaccine and natural infection acquired before HIV infection
Authors: ISA M. B. , PAVAN J. V. , SICILIA DON P. , GRUTADAURIA S. , MARTINEZ L. C. , GIORDANO M. O. , MASACHESSI G. , BARRIL P. A. , NATES S. V. 
Published: October 2013

SUMMARYLittle is known about long-lasting measles protective immunity when exposure to wild-type or vaccine measles virus precedes HIV infection. The results obtained suggest that measles immunity wanes and the lowest measles geometric mean titres (GMT) were significantly associated with measles vaccine-induced immunity in individuals that later developed HIV infection (86% prevalence, GMT 164 mIU/ml) compared to naturally induced immunity in HIV-infected adults (100% prevalence, GMT 340 mIU/ml, P = 0·0082) or non-HIV infected adults (100%, GMT 724 mIU/ml, P = 0·0001), and vaccine-induced immunity in non-HIV-infected adults (100%, GMT 347 mIU/ml, P = 0·017). The study was conducted in an area without wild-type virus circulation since 2000. The absence of virus circulating may alter the paradigm of lifelong immunity to measles virus after vaccination. As the proportion of HIV-infected individuals possessing only vaccine-induced immunity continues to grow, checking the status of measles immunity in this group is strongly recommended.
Visible ink: A flexible and individually tailored writing intervention for cancer patients
Authors: Corner Geoffrey W. , Jhanwar Sabrina M. , Kelman Judith , Pessin Hayley , Stein Emma , Breitbart William 
Published: October 2013

AbstractObjectives:Subjective reports on the effectiveness of and satisfaction with writing interventions in medical populations have indicated that they can have a profound impact on patients. Further, past research on these programs has demonstrated that they can lead to a number of different positive outcomes depending on the personal characteristics of the participating patients and the type of writing with which they are tasked. For this reason, a flexible and individually tailored writing intervention may be particularly effective for patients, molding its approach to their desires and backgrounds. This paper examines Visible Ink, a writing program for cancer patients at Memorial Sloan-Kettering Cancer Center (MSKCC) that follows this model.Methods:At Visible Ink's First Fall Writing Festival in November 2012, an optional survey was provided to all program participants in attendance, capturing both quantitative and qualitative information on patient experiences in the program. Twenty-nine surveys were completed.Results:The program appears to have a variety of positive effects, including fostering personal growth and providing a positive distraction. Respondents reported that they write in a number of different genres on topics both related and not related to their illnesses, which supports the flexible model of the program. All respondents indicated that they would recommend the program to others, and satisfaction with the program's general approach (i.e., individualized work with a writing coach) was unanimous. A few areas for potential improvement were also identified, most of which involved expanding the services and events offered by the program.Significance of results:Despite the limitations of this survey (e.g., small sample size and low response rate), its results support the promise of the Visible Ink model and demonstrate participants' satisfaction with the program. Future research can more thoroughly examine Visible Ink's effectiveness, and additional resources could enable the program to expand.
Utilizing participation in meaningful occupation as an intervention approach to support the acute model of inpatient palliative care
Authors: Ashworth Erin 
Published: October 2013

AbstractPalliative care is a model of care that aims to improve quality of life (QOL) for patients and their families/carers who are facing the challenges associated with a life limiting illness (WHO, 2012). Until recently, palliative care has been seen to be largely focused on the medical management of specific symptoms, with little or no consideration given to the patient's occupational identity and goals.Occupational therapy is a profession whose core philosophy is grounded in occupational participation. Occupational therapists have the skills and expertise to incorporate an individual's occupational performance goals into their treatment plan, thereby helping people to participate in personally meaningful occupations, within the limitations of their illness and physical capacity.The present article aims to illustrate (using case-study examples) how personally meaningful occupational participation can better support an acute model of palliative care practice, resulting in better patient outcomes and improved quality of life for both patients and their carers.
A subset of gastric cancers with EGFR amplification and overexpression respond to cetuximab therapy
Authors: Zhang Lianhai , Yang Jie , Cai Jie , Song Xiaoming , Deng Jianyun , Huang Xuesong , Chen Dawei , Yang Mengmeng , Wery Jean-Pierre , Li Shuangxi , Wu Aiwen , Li Ziyu , Li Zhongwu , Liu Yiqiang , Chen Yiyou , Li Qixiang , Ji Jiafu 
Published: October 2013

AbstractA preclinical trial identified 4 of 20 (20%) gastric cancer (GC) patient-derived xenografts responded to cetuximab. Genome-wide profiling and additional investigations revealed that high EGFR mRNA expression and immunohistochemistry score (3+) are associated with tumor growth inhibition. Furthermore, EGFR amplification were observed in 2/4 (50%) responders with average copy number 5.8 and >15 respectively. Our data suggest that a GC subtype with EGFR amplification and overexpression benefit from cetuximab treatment.
Whole genome comparison of donor and cloned dogs
Authors: Kim Hak-Min , Cho Yun Sung , Kim Hyunmin , Jho Sungwoong , Son Bongjun , Choi Joung Yoon , Kim Sangsoo , Lee Byeong Chun , Bhak Jong , Jang Goo 
Published: October 2013

AbstractCloning is a process that produces genetically identical organisms. However, the genomic degree of genetic resemblance in clones needs to be determined. In this report, the genomes of a cloned dog and its donor were compared. Compared with a human monozygotic twin, the genome of the cloned dog showed little difference from the genome of the nuclear donor dog in terms of single nucleotide variations, chromosomal instability and telomere lengths. These findings suggest that cloning by somatic cell nuclear transfer produced an almost identical genome. The whole genome sequence data of donor and cloned dogs can provide a resource for further investigations on epigenetic contributions in phenotypic differences.
Two Alternative Sutureless Strategies for Aortic Valve Replacement
Authors: Concistrè Giovanni , Santarpino Giuseppe , Pfeiffer Steffen , Farneti Pierandrea , Miceli Antonio , Chiaramonti Francesca , Solinas Marco , Glauber Mattia , Fischlein Theodor 
Published: October 2013

Objective Important comorbid conditions in patients referred for aortic valve replacement (AVR) require less invasive strategies. We describe our initial experience with the Perceval S (Sorin Group, Saluggia, Italy) and 3f Enable (Medtronic, Minneapolis, MN USA) sutureless aortic bioprostheses. Methods We compared intraoperative data, postoperative clinical outcomes, and echocardiographic results from patients receiving a Perceval S ( P group; n = 97) or a 3f Enable (E group; n = 32) prosthesis in two cardiac surgery departments (Nuremberg, Germany, and Massa, Italy). Results Baseline patient characteristics were similar in both groups, except for mean ± SD body surface area ( P group = 2.01 ± 2.9 m2, E group = 1.83 ± 3.8 m2; P < 0.001). Sixty-five patients (67%) in the P group and 19 patients (59.5%) in the E group ( P = 0.22) underwent minimally invasive AVR with either ministernotomy or right anterior minithoracotomy approach. Concomitant procedures were performed in 37 patients (38%) in the P group and 9 patients (28%) in the E group ( P = 0.56). In-hospital mortality was 2%. The mean ± SD prosthesis diameter was 23.5 ± 1.4 mm ( P group) compared with 22.1 ± 2 mm (E group) ( P < 0.001). In isolated AVR, aortic cross-clamp time was 36 ± 12.7 minutes in the P group and 66 ± 18 minutes in the E group ( P < 0.001). At a mean ± SD follow-up of 8.3 ± 4.5 months, survival was 97% (one death in the P group). In five patients ( P group = 1, E group = 4), a moderate paravalvular leak was present ( P = 0.013). The mean ± SD transvalvular gradient was 9.1 ± 3.3 mm Hg with the Perceval S and 11.2 ± 5.2 mm Hg with the 3f Enable ( P = 0.017). Conclusions Aortic valve replacement with sutureless aortic bioprosthesis is feasible, also with a minimally invasive approach. The Perceval S showed lower operative times and moderate paravalvular leaks and lower mean transvalvular gradients than did the 3f Enable, related to the larger diameter of the Perceval S implanted. Both prostheses showed an excellent hemodynamic performance. This new technology needs long-term follow-up.
Right Superior Mediastinal Lymph Node Dissection in Thoracoscopic Surgery Using a Bipolar Sealing Device
Authors: Kamiyoshihara Mitsuhiro , Igai Hitoshi , Ibe Takashi , Kawatani Natsuko , Ohtaki Yoichi , Shimizu Kimihiro , Takeyoshi Izumi 
Published: October 2013

Objective This study investigated the use of a new bipolar sealing device (BSD) in right superior mediastinal lymph node dissection during thoracoscopic surgery. Methods The study population consisted of 42 consecutive patients undergoing lobectomy with right superior mediastinal lymph node dissection for primary lung cancer. Operative results were compared with those of conventional surgery in 42 background-matched controls. The primary endpoint for the present analysis was the success of right superior mediastinal lymph node dissection during thoracoscopic surgery using a BSD. The secondary endpoints included the duration of the operation, number of dissected lymph nodes, chest drainage volume and duration, postoperative hospital stay, morbidity, and mortality. Results The BSD was used successfully in 42 patients. No significant difference in duration of lymph node dissection, chest drainage volume, drainage duration, or number of dissected lymph nodes was observed between the study group and the controls. Because of a learning curve, the procedure initially took more than 20 minutes to complete, but surgical time was reduced to approximately 15 minutes after the procedure was performed in 15 patients. Conclusions Our method is safe and in no way inferior to the conventional procedure. The tendency of the learning curve suggests that a significantly shorter duration of lymph node dissection is possible using this method.
Appendiceal Neuroendocrine Tumours in Childhood
Authors: Virgone Calogero , Cecchetto Giovanni , Alaggio Rita , Ferrari Andrea , Bisogno Gianni , Conte Massimo , Inserra Alessandro , Fagnani Anna M. , Indolfi Paolo , Salfi Nunzio , Dall'Igna Patrizia 
Published: October 2013

ABSTRACTBackground:Neuroendocrine tumours (NETs) of the appendix are slow‐growing tumours and, although rare, they are the most common gastrointestinal epithelial tumours in childhood and adolescence. The treatment and the follow‐up screenings have not been standardised. In addition to this, although tumour size is considered the main prognostic variable to define the aggressiveness of approach, a precise cutoff needs to be established.Methods:A total of 113 patients younger than 18 years with a diagnosis of appendiceal NETs were registered as of January 1, 2000, until May 30, 2013, within the Rare Tumors in Pediatric Age (TREP) project, an Italian multi‐institutional network dedicated to rare tumours in children and adolescents. The recommendations of the Rare Tumors in Pediatric Age study included imaging and laboratory investigations. The treatment after appendectomy was decided on the basis of histology, tumour size, and imaging; primary reexcision (PRE) was not recommended in completely excised tumours, regardless of tumour size and invasiveness.Results:A total of 113 of 113 patients had a diagnosis of well‐differentiated NETs; in 108 of 113 the tumour was smaller than 2 cm and in 5, larger than 2 cm. Excision margins were free in 111 of 113 patients. In 3 of 113 a PRE was performed, and in 1 residual tumour was detected. All 113 of 113 patients are alive in complete remission (median follow‐up of 41 months).Conclusions:Reported data and our experience showed that no relapse or death occurred in children and adolescents affected by appendiceal NETs. Appendectomy alone should be considered curative for most patients, and a more aggressive surgical approach is warranted in the cases with incompletely excised tumours.
Maternal effects of carotenoid supplementation in an ornamented cichlid fish
Authors: Brown Alexandria C. , Leonard Heather M. , McGraw Kevin J. , Clotfelter Ethan D. 
Published: October 2013

Summary

Carotenoid‐ornamented animals may transfer dietary carotenoid pigments to offspring as well as to their ornament and other competing physiological demands. If carotenoid supplementation increases offspring growth or survival, females should preferentially allocate supplemental carotenoids to offspring rather than ornamentation.

We tested whether ornamented convict cichlid (Amatitlania siquia) mothers increase carotenoid allocation to eggs with access to dietary carotenoid supplementation, and whether beneficial maternal effects of carotenoid supplementation were transferred to offspring.

Maternal effects of carotenoid supplementation were found; offspring from mothers that ate carotenoids benefited in terms of growth and survival parameters compared with offspring from non‐supplemented mothers. Contrary to predictions, maternal coloration was not sacrificed for fecundity: mothers maintained their coloration and integument carotenoids even though increased carotenoids in the maternal diet benefited the offspring. Furthermore, carotenoid supplementation did not increase the carotenoids deposited in eggs.

This work is the first to show that indirect maternal effects of carotenoid supplementation increased the survival and growth of offspring. Indirect benefits may reduce the cost of carotenoid allocation to offspring, but the mechanism for how carotenoids support offspring development is still unknown.
Divergence in threat sensitivity among aquatic larvae of cryptic mosquito species
Authors: Roux Olivier , Diabaté Abdoulaye , Simard Frédéric 
Published: October 2013

Summary

Predation is a major evolutionary force driving speciation. The threat‐sensitive response hypothesis predicts that prey adjust and balance the time spent on a costly antipredator response with other activities that enhance their fitness. Thus, prey able to develop an antipredator response proportional to risk intensity should have a selective advantage.

Knowledge on how evolution has shaped threat sensitivity among closely related species exposed to different predation pressures is scarce, prompting investigations to better predict and explain its effect on communities.

We explored and compared the antipredator response of aquatic mosquito larvae in three sibling species of the Anopheles gambiae complex, with contrasting larval biologies in Burkina Faso. Anopheles arabiensis and An. gambiae sensu stricto breed in temporary water collections where predator densities are low, whereas Anopheles coluzzii is able to thrive in permanent pools where the predation pressure is much higher. We hypothesized that the increase and decline of behavioural antipredator responses might differ between the three species over time. To test this hypothesis, progenies of field‐collected mosquitoes were experimentally exposed to a range of soluble predation cues and their response was monitored for up to 48 h.

The three species were all threat sensitive but their reaction norms differed. For the range of concentrations tested, An. coluzzii larvae gradually increased in antipredator response, whereas An. gambiae larvae readily displayed antipredator behaviour at low concentrations leading to a saturation of the response for high cue concentrations. An. arabiensis displayed a narrower reaction norm with low response intensity. Larval instars did not differ in their threat sensitivity. The antipredator behaviour of the three species waned after about 1 h of exposure. Early instars tended to express antipredation behaviour for longer than did older instars.

This study provides information on how aquatic prey species with an aerial adult stage manage larval predation risk over time according to cue concentrations and suggests that different predation pressures might play a role as a disruptive selective force fostering habitat segregation and speciation within the An. gambiae complex. The evolution of phenotypic plasticity is further discussed in the light of divergent predation pressures.
Why preferences and institutions change: A systematic process analysis of credit rating in Germany
Authors: Trampusch Christine 
Published: October 2013

AbstractThis article argues that a within‐case analysis of the causes and patterns of the institutionalisation of rating in the German financial system offers fresh insights into change in the major socioeconomic institutions of advanced capitalism. Using the method of systematic process analysis, the article explores the expansion of credit rating in the German banking system from three perspectives: historical (power), sociological (diffusion) and behavioural institutionalism (prospect theory). It demonstrates that the proliferation of credit rating resulted from a change of preference on the part of large banks. With Germany as a least likely case for successfully implementing rating, the study's main lesson is that institutional analysis may benefit from incorporating behavioural institutionalism into the analysis of preference change because this cites economic motivations as causes of preference shifts and institutional changes.
Creating and Supporting a Mixed Methods Health Services Research Team
Authors: Bowers Barbara , Cohen Lauren W. , Elliot Amy E. , Grabowski David C. , Fishman Nancy W. , Sharkey Siobhan S. , Zimmerman Sheryl , Horn Susan D. , Kemper Peter 
Published: October 2013

ObjectiveTo use the experience from a health services research evaluation to provide guidance in team development for mixed methods research.MethodsThe Research Initiative Valuing Eldercare (THRIVE) team was organized by the Robert Wood Johnson Foundation to evaluate The Green House nursing home culture change program. This article describes the development of the research team and provides insights into how funders might engage with mixed methods research teams to maximize the value of the team.ResultsLike many mixed methods collaborations, the THRIVE team consisted of researchers from diverse disciplines, embracing diverse methodologies, and operating under a framework of nonhierarchical, shared leadership that required new collaborations, engagement, and commitment in the context of finite resources. Strategies to overcome these potential obstacles and achieve success included implementation of a Coordinating Center, dedicated time for planning and collaborating across researchers and methodologies, funded support for in‐person meetings, and creative optimization of resources.ConclusionsChallenges are inevitably present in the formation and operation of effective mixed methods research teams. However, funders and research teams can implement strategies to promote success.
Key innovations in ruminant evolution: a paleontological perspective
Authors: DeMIGUEL Daniel , AZANZA Beatriz , MORALES Jorge 
Published: October 2013

AbstractKey innovations are newly acquired structures that permit the performance of a new function and open new adaptive zones, and are, therefore, of paramount significance for understanding the history of the Ruminantia, particularly its diversification through the Miocene. Here we review and discuss what is known about these evolutionary novelties, with special emphasis on the appearance and evolution of cranial appendages and high‐crowned (or hypsodont) teeth. Cranial appendages probably favored the diversification of pecorans by being structures strongly related to sexual selection, whereas the acquisition of hypsodont teeth could have expanded potential dietary breadth and allowed species to extend diets into the grazing range without eliminating browsing as a potential diet. When analyzed in conjunction with patterns of faunal diversity and in the context of climatic changes, it seems that the overall view that ruminant cranial appendages and hypsodonty may have started responding to increased patterns of seasonality and the opening‐up of ecosystems is roughly valid. Instead, they occurred through several distinct pulses and varied widely among continents. This review is, to our knowledge, the first to highlight that the evolution of these innovations has been far from constant and uniform through time. Furthermore, we identify that both a first attempt to increase hypsodonty starting in the early Miocene and a first evolution of antlers and pronghorns were interrupted as a consequence of wide climatic fluctuations in the early–middle Miocene transition.