bluuebunny/crossref_metadata_2025_split huggingface dataset:
An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J. 
Published: February 2013

Abstract
The sterol regulatory element-binding proteins (SREBP) are key transcriptional regulators of lipid metabolism and cellular growth. It has been proposed that SREBP signaling regulates cellular growth through its ability to drive lipid biosynthesis. Unexpectedly, we find that loss of SREBP activity inhibits cancer cell growth and viability by uncoupling fatty acid synthesis from desaturation. Integrated lipid profiling and metabolic flux analysis revealed that cancer cells with attenuated SREBP activity maintain long-chain saturated fatty acid synthesis, while losing fatty acid desaturation capacity. We traced this defect to the uncoupling of fatty acid synthase activity from stearoyl-CoA desaturase 1 (SCD1)–mediated desaturation. This deficiency in desaturation drives an imbalance between the saturated and monounsaturated fatty acid pools resulting in severe lipotoxicity. Importantly, replenishing the monounsaturated fatty acid pool restored growth to SREBP-inhibited cells. These studies highlight the importance of fatty acid desaturation in cancer growth and provide a novel mechanistic explanation for the role of SREBPs in cancer metabolism. Cancer Res; 73(9); 2850–62. ©2013 AACR.
Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer
Authors: Martens-de Kemp Sanne R. , Nagel Remco , Stigter-van Walsum Marijke , van der Meulen Ida H. , van Beusechem Victor W. , Braakhuis Boudewijn J.M. , Brakenhoff Ruud H. 
Published: February 2013

AbstractPurpose: Despite continuous improvement of treatment regimes, the mortality rates for non–small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) remain disappointingly high and novel anticancer agents are urgently awaited.Experimental Design: We combined the data from genome-wide siRNA screens on tumor cell lethality in a lung and a head and neck cancer cell line.Results: We identified 71 target genes that seem essential for the survival of both cancer types. We identified a cluster of 20 genes that play an important role during G2–M phase transition, underlining the importance of this cell-cycle checkpoint for tumor cell survival. Five genes from this cluster (CKAP5, KPNB1, RAN, TPX2, and KIF11) were evaluated in more detail and have been shown to be essential for tumor cell survival in both tumor types, but most particularly in HNSCC. Phenotypes that were observed following siRNA-mediated knockdown of KIF11 (kinesin family member 11) were reproduced by inhibition of KIF11 using the small-molecule inhibitor ispinesib (SB-715992). We showed that ispinesib induces a G2 arrest, causes aberrant chromosome segregation, and induces cell death in HNSCC in vitro, whereas primary keratinocytes are less sensitive. Furthermore, growth of HNSCC cells engrafted in immunodeficient mice was significantly inhibited after ispinesib treatment.Conclusion: This study identified a wide array of druggable genes for both lung and head and neck cancer. In particular, multiple genes involved in the G2–M checkpoint were shown to be essential for tumor cell survival, indicating their potential as anticancer targets. Clin Cancer Res; 19(8); 1994–2003. ©2013 AACR.
Activity of a Py–Im Polyamide Targeted to the Estrogen Response Element
Authors: Nickols Nicholas G. , Szablowski Jerzy O. , Hargrove Amanda E. , Li Benjamin C. , Raskatov Jevgenij A. , Dervan Peter B. 
Published: February 2013

Abstract
Pyrrole-imidazole (Py–Im) polyamides are a class of programmable DNA minor groove binders capable of modulating the activity of DNA-binding proteins and affecting changes in gene expression. Estrogen receptor alpha (ERα) is a ligand-activated hormone receptor that binds as a homodimer to estrogen response elements (ERE) and is a driving oncogene in a majority of breast cancers. We tested a selection of structurally similar Py–Im polyamides with differing DNA sequence specificity for activity against 17β-estadiol (E2)–induced transcription and cytotoxicity in ERα positive, E2-stimulated T47DKBluc cells, which express luciferase under ERα control. The most active polyamide targeted the sequence 5′-WGGWCW-3′ (W = A or T), which is the canonical ERE half site. Whole transcriptome analysis using RNA-Seq revealed that treatment of E2-stimulated breast cancer cells with this polyamide reduced the effects of E2 on the majority of those most strongly affected by E2 but had much less effect on the majority of E2-induced transcripts. In vivo, this polyamide circulated at detectable levels following subcutaneous injection and reduced levels of ER-driven luciferase expression in xenografted tumors in mice after subcutaneous compound administration without significant host toxicity. Mol Cancer Ther; 12(5); 675–84. ©2013 AACR.
Suppression of AKT Phosphorylation Restores Rapamycin-Based Synthetic Lethality in SMAD4-Defective Pancreatic Cancer Cells
Authors: Le Gendre Onica , Sookdeo Ayisha , Duliepre Stephie-Anne , Utter Matthew , Frias Maria , Foster David A. 
Published: February 2013

Abstract
mTOR has been implicated in survival signals for many human cancers. Rapamycin and TGF-β synergistically induce G1 cell-cycle arrest in several cell lines with intact TGF-β signaling pathway, which protects cells from the apoptotic effects of rapamycin during S-phase of the cell cycle. Thus, rapamycin is cytostatic in the presence of serum/TGF-β and cytotoxic in the absence of serum. However, if TGF-β signaling is defective, rapamycin induced apoptosis in both the presence and absence of serum/TGF-β in colon and breast cancer cell lines. Because genetic dysregulation of TGF-β signaling is commonly observed in pancreatic cancers—with defects in the Smad4 gene being most prevalent, we hypothesized that pancreatic cancers would display a synthetic lethality to rapamycin in the presence of serum/TGF-β. We report here that Smad4-deficient pancreatic cancer cells are killed by rapamycin in the absence of serum; however, in the presence of serum, we did not observe the predicted synthetic lethality with rapamycin. Rapamycin also induced elevated phosphorylation of the survival kinase Akt at Ser473. Suppression of rapamycin-induced Akt phosphorylation restored rapamycin sensitivity in Smad4-null, but not Smad4 wild-type pancreatic cancer cells. This study shows that the synthetic lethality to rapamycin in pancreatic cancers with defective TGF-β signaling is masked by rapamycin-induced increases in Akt phosphorylation. The implication is that a combination of approaches that suppress both Akt phosphorylation and mTOR could be effective in targeting pancreatic cancers with defective TGF-β signaling.
Visual Overview: http://mcr.aacrjournals.org/content/11/5/474/F1.large.jpg.
Mol Cancer Res; 11(5); 474–81. ©2013 AACR.
The Optimal Range of International Normalized Ratio for Radiofrequency Catheter Ablation of Atrial Fibrillation During Therapeutic Anticoagulation With Warfarin
Authors: Kim Jin-Seok , Jongnarangsin Krit , Latchamsetty Rakesh , Chugh Aman , Ghanbari Hamid , Crawford Thomas , Yokokawa Miki , Good Eric , Bogun Frank , Pelosi Frank , Morady Fred , Oral Hakan 
Published: February 2013

Background—
Uninterrupted anticoagulation with warfarin during radiofrequency catheter ablation (RFA) of atrial fibrillation is associated with a lower risk of periprocedural complications than when warfarin is temporarily discontinued. However, the optimal international normalized ratio (INR) levels during RFA have not been defined.

Methods and Results—

In this retrospective analysis, RFA was performed in 1133 consecutive patients (mean age, 61±10 years) with paroxysmal (550) or persistent atrial fibrillation (583). Patients were grouped based on the INR on the day of RFA. There was a quadratic relationship between the INR and bleeding and vascular complications (
P
<0.001). Complications were less prevalent when INR was ≥2.0 and ≤3.0 (5% [31/572]) than when INR was <2.0 (10% [49/485];
P
=0.004) and >3.0 (12% [9/76];
P
=0.03). The prevalence of pericardial tamponade (1%) was similar at all INRs. From the quadratic model, the optimal range of INR was calculated as 2.1 to 2.5. INRs<2.0 and >3.0 were associated with a >2-fold increase in complications, with a further steep rise beyond an INR>3.5. Concomitant clopidogrel use was associated with a significant increase in complications at all INRs (odds ratio=3.1; ±95% confidence interval, 1.4–7.4). Unfractionated heparin requirements to maintain a therapeutic activated clotting time during RFA was reduced by 50% in patients with an INR>2.0.

Conclusions—
The optimal INR range during uninterrupted periprocedural anticoagulation using warfarin is narrow. Therefore, INR levels should be carefully monitored in preparation for RFA of atrial fibrillation.
The Anatheistic Wager: faith after Faith
Authors: Treanor Brian 
Published: February 2013

AbstractThe hermeneutic wager described in Richard Kearney’s Anatheism seems to share a number of characteristics with both agnosticism and other postmodern religious wagers. All these approaches maintain a certain epistemological humility with respect to what we can and cannot know about God. Nevertheless, the anatheistic wager includes an existential aspect that risks commitment even in the uncertainty of epistemological uncertainty. The fivefold motion of imagination, humility, commitment, discernment, and hospitality circumscribes a wager that is neither the blind leap of fideism nor safe assurance of certainty.
Grammar of the Uncanny
Authors: Yates Christopher 
Published: February 2013

AbstractInspired by the contemporary intersection between hermeneutics, phenomenology, and psychoanalysis on the one hand, and poetics on the other, this article is a study in the peculiar manifestation of strangeness that obtains within the self. It is a descriptive and autobiographical account of a disclosure that, though common, is irreducible to traditional categories of mimesis and ontology: the experience of displacement in self-consciousness and embodiment. Drawing upon insights by Sigmund Freud and Martin Heidegger, and in dialogue with the poetics of Jules Renard, the essay seeks to appreciate a certain grammar of ipseity that is formative of subjectivity and constitutive of the poetic vocation. Emphasis is placed on the productive quality of the “between” (Zwischen) as it obtains both geographically and internally, and the concentration potentially resulting from the “between” as one grapples to configure in language the experience of playing “host” to one’s own self.
Reexamining the Allegorical Hermeneutic in A. B. Yehoshua’s A Late Divorce
Authors: Devir Nathan Paul 
Published: February 2013

AbstractThis article demonstrates the ways in which the allegorical hermeneutic of A. B. Yehoshua’s novelA Late Divorce(1982) is inextricably linked to the intertextual reservoir of Judaic culture, particularly by way of its dependence upon the stories, themes, motifs, and characters from the Judaic textual tradition. Additionally, it shows how Yehoshua’s novel subverts those narrative patterns along the lines of emphatically Israeli concerns, simultaneously providing a totemically charged connection with the Judaic textual tradition and evidence of a radical departure from it. Drawing on the theoretical perspectives of archetypal psychology, this study also provides a reexamination of the much-discussed persona of Naomi, the text’s central female character, with respect to her role as the “mediatrix of the unknown” and her use of predominantly culturally inherited points of reference to link the thematic portions of the novel.
Bonded Labour in Southeast Asia: Introduction
Authors: Derks Annuska 
Published: February 2013

AbstractThe introduction of this special issue takes up the questions: Why ‘bonded labour’? What do we mean by it? And, why focus on ‘bonded labour’ now? Answers to these questions require an effort of definition, as well as contextualisation, of a phenomenon that, though long expected to disappear with societal and economic developments, has persisted or re-emerged in the wake of current processes of transnational migration and globalisation. The introduction briefly discusses longstanding theoretical debates on bondage in past and present Asia, as well as new insights derived from a Swiss research project focusing on ‘Contemporary Forms of Bonded Labour in Southeast Asia.’
The Politics of Bonded Labour among Rattan-Collectors in South-Western Sumatra, Late 1980s
Authors: Znoj Heinzpeter 
Published: February 2013

AbstractAt the end of the 1980s, the commercial search for rattan in the newly-established Kerinci-Seblat National Park in south-western Sumatra relied on debt bondage as a means of labour control. In a village at the fringes of the park, land and water were ample and free resources but labour power was scarce. Since their land was of no monetary value, the local rice farmers had to pawn their own labour power to secure loans from traders. The focus in the article is on how this debt-bondage was negotiated and discursively constructed on an everyday basis between the indebted rattan collectors and their creditors. In these micro-politics of debt-bondage, the collectors relied on subsistence ethics to openly default on what they called ‘war debts’ to limit the degree of their exploitation. The article shows that this case of debt bondage in forest product collection was an inherently contested and unstable institution that was embedded in notions of mutual obligations within patron-client ties.
East Timor: A Dependent State Expert in Mass Communication
Authors: Berlie Jean A. 
Published: February 2013

AbstractIn 2010, despite the payment of important royalties from oil and gas resources, East Timor continues to be heavily dependent on the United Nations, including Australia, Portugal and other donor countries. Despite its expertise in mass communication, East Timor needs new type of governance to reduce both the impoverishment of the people and youth unemployment. Among other possible options, the implementation of new laws on education and vocational schools are suggestions to develop the country, as well as having new leaders replace the UN staff, together with a new military and police force after drastic reforms. This may reduce youth disillusionment. CNRT, the National Congress for the Reconstruction of East Timor, the party of Prime Minister Xanana Gusmão, and Fretilin currently dominate the political life of the country. Unity and motivation of the majority who cultivate the land may restore the confidence, courage and creativity of the Timorese.
From One-Stop Graft to Costly Corruption Webs: Democratisation and Shifting Patterns of Corruption in Korea
Authors: Schopf James C. 
Published: February 2013

Abstract
Democratisation has brought a new, riskier pattern of corruption to Korea. More groups and institutions have secured a role in a more inclusive democratic policy making process. As a result, corruption schemes now require the consent of a wide and diverse set of veto players, often including the political opposition, producing expansive democratic ‘corruption webs’. The key democratic element of competition for votes rewards opposition members in the web for blowing the whistle. Increased likelihood of exposure and punishment deter many from corruption, which has subsequently declined in Korea under democracy, as measured by perception polls, experience surveys and objective measures of elite rent exchange. The Roh Moo-hyeon NACF scandals demonstrate that democratic corruption webs also mitigate damage from scandals — forcing participants to limit rent exchange to minimise exposure to clean veto players. Democratic oversight ensures that even bribe-taking officials implement policy according to publicly-declared objectives. Finally, competition for votes encourages timely exposure of democratic corruption rackets.
Democratic Decentralisation and Pro-poor Policy Reform in Indonesia: The Politics of Health Insurance for the Poor in Jembrana and Tabanan
Authors: Rosser Andrew , Wilson Ian 
Published: February 2013

Abstract
This paper explores the conditions under which democratic decentralisation has contributed to pro-poor policy reform in Indonesia by examining the politics of health insurance for the poor in two Indonesian districts, Jembrana and Tabanan, both located in Bali. Governments in these districts have responded quite differently to the issue of health insurance for the poor since they gained primary responsibility for health policy as a result of Indonesia’s implementation of decentralisation in 2001. We argue that this variation has reflected differences in the nature of district heads’ political strategies — particularly the extent to which they have sought to develop a popular base among the poor — and that these in turn have reflected differences in their personal networks, alliances and constituencies. Comparative research suggests that pro-poor outcomes have only occurred in developing countries following democratic decentralisation when social-democratic political parties have secured power at the local level. In the Indonesian case, we suggest, political parties are not well defined in ideological and programmatic terms and tend to act as electoral vehicles for hire and mechanisms for the distribution of patronage, while local-level politics is increasingly dominated by the executive arm of government. Hence the pathway to pro-poor policy reform has been different — namely, via the emergence of local executives who pursue their interests and those of allies and backers via populist strategies with or without the support of parties.
Media Coverage and Solidarity after Tragedies: The Reporting of School Shootings in Two Nations
Authors: Hawdon James , Hawdon James , Oksanen Atte , Hawdon James , Oksanen Atte , Räsänen Pekka 
Published: February 2013

Abstract
Although considerable research analyzes the media coverage of school shootings, there is a lack of cross-national comparative studies. Yet, a cross-national comparison of the media coverage of school shootings can provide insight into how this coverage can affect communities. Our research focuses on the reporting of the school shootings at Virginia Tech in the U.S. and Jokela and Kauhajoki in Finland. Using 491 articles from the New York Times and Helsingin Sanomat published within a month of each shooting we investigate how reports vary between the nations and among the tragedies. We investigate if one style of framing a tragedy, the use of a “tragic frame,” may contribute to differences in the communities’ response to the events.
Multiple Secularities: Toward a Cultural Sociology of Secular Modernities
Authors: Wohlrab-Sahr Monika , Wohlrab-Sahr Monika , Burchardt Marian 
Published: February 2013

Abstract
For more than two decades sociological debates over religion and secularization have been characterized by a confrontation between (often American) critics and (mostly European) defenders of secularization theories. At the same time, there was a remarkable rise in public debates about the role of secularism in political regimes and in national as well as civilizational frameworks. Against this backdrop this paper presents the conceptual framework of “multiple secularities” with a view to refocusing sociological research on religion and secularity. We will demonstrate that it can stimulate new ways of theorizing the relationship of religion and secularity in a variety of modern environments. Arguing for a reformulation of this relationship within the framework of cultural sociology, we conceptualize “secularity” in terms of the cultural meanings underlying the differentiation between religion and non-religious spheres. Building on Max Weber we distinguish four basic ideal-types of secularity that are related to specific reference problems and associated with specific guiding ideas. Finally, we illustrate the use of the concept with regard to selected case-studies.
Judicial Practice at the Court of First Instance Tunis: The Case of Divorce for Harm on the Grounds of Domestic Violence
Authors: Voorhoeve Maaike 
Published: February 2013

AbstractTunisian personal status law is internationally known for its “progressive” character. Nevertheless, it is argued in Tunisian doctrine that judicial practice is characterised by “conservatism,” and that judges applyshariaand “custom” instead of or at least together with legislation. This article examines the practices at the Court of First Instance Tunis in divorce cases where the wife accuses her husband of domestic violence. It is demonstrated that strict evidence requirements applied by judges prevent most women from obtaining divorce for harm (darar), a type of divorce that has large financial advantages for the wife. However, the material does not indicate that judges simply applyshariaor “custom”: judges argue that strict evidence requirements are necessary in the light of their experience with numerous false accusations. Moreover, judges do take accusations of domestic violence into consideration in other types of divorce.
Interfaith Community Organizing Emerging Theological and Organizational Challenges
Authors: Fulton Brad , Wood Richard L. 
Published: February 2013

Abstract
Interfaith work in the United States takes diverse forms: from grass-roots collaboration on projects such as feeding the homeless, to locally-sponsored interfaith dialogues, collaborations sponsored by national denominational bodies and shared work on federal ‘faith-based initiatives’. This article profiles the characteristics and dynamics of a particular type of interfaith work, done under the rubric of ‘broad-based’, ‘faith-based’ or ‘congregation-based’ community organizing. For reasons detailed below, we term this form of interfaith and religious-secular collaboration ‘institution-based community organizing’. By drawing on results from a national survey of all local institution-based community organizations active in the United States in 2011, this article documents the significance of the field, its broadly interfaith profile, how it incorporates religious practices into organizing, and the opportunities and challenges that religious diversity presents to its practitioners and to North American society.1
The Transformation of the Torah in Second Temple Judaism
Authors: Collins John J. 
Published: February 2013

Abstract
While the Torah enjoys central importance in the sectarian scrolls, it is not nearly so central in the Aramaic texts found at Qumran. These texts show familiarity with the stories of Genesis and Exodus, but they treat them as sources for stories and wisdom instruction rather than for prescriptive law. The same is true of Ben Sira. Ancestral laws were very important in the Hellenistic world, but their importance was largely symbolic. Even Ezra seems to have focused primarily on a few issues of symbolic importance. Only after the Maccabean revolt do we begin to get sustained halakic discussion in such books as the Temple Scroll and Jubilees. The increased prominence of halakic disputes went hand in hand with the rise of sectarianism.