bluuebunny/crossref_metadata_2025_split huggingface dataset:
Feature‐based high‐availability mechanism for quantile tasks in real‐time data stream processing
Authors: Ding Weilong , Han Yanbo , Wang Jing , Zhao Zhuofeng 
Published: December 2013

SUMMARYUnder distributed Cloud environment, the real‐time and continuous data stream makes the availability during processing essential but expensive. For aggregation tasks of data stream processing systems, traditional replica‐based high‐availability mechanisms require large overheads at run‐time and long recovery latency at fail‐time, because of specific nature of aggregations. In this paper, we focus on the typical quantile tasks and propose a feature‐based high‐availability mechanism to reduce related overhead and the latency. With the help of monitor module, quantile feature is maintained incrementally through histogram synopsis over time‐based sliding window, and the failed quantile tasks can be recovered precisely with high probability in an efficient way. The effectiveness has been analyzed theoretically, and meanwhile, the acceptable tradeoff between overheads and performance has been demonstrated by comprehensive experiments on both synthetic and real data. Copyright © 2013 John Wiley & Sons, Ltd.
Clinical Relevance and Therapeutic Significance of MicroRNA-133a Expression Profiles and Functions in Malignant Osteosarcoma-Initiating Cells
Authors: Fujiwara Tomohiro , Katsuda Takeshi , Hagiwara Keitaro , Kosaka Nobuyoshi , Yoshioka Yusuke , Takahashi Ryou-U , Takeshita Fumitaka , Kubota Daisuke , Kondo Tadashi , Ichikawa Hitoshi , Yoshida Akihiko , Kobayashi Eisuke , Kawai Akira , Ozaki Toshifumi , Ochiya Takahiro 
Published: December 2013

Abstract
Novel strategies against treatment-resistant tumor cells remain a challenging but promising therapeutic approach. Despite accumulated evidence suggesting the presence of highly malignant cell populations within tumors, the unsolved issues such as in vivo targeting and clinical relevance remain. Here, we report a preclinical trial based on the identified molecular mechanisms underlying osteosarcoma-initiating cells and their clinical relevance. We identified key microRNAs (miRNAs) that were deregulated in a highly malignant CD133high population and found that miR-133a regulated the cell invasion that characterizes a lethal tumor phenotype. Silencing of miR-133a with locked nucleic acid (LNA) reduced cell invasion of this cell population, and systemic administration of LNA along with chemotherapy suppressed lung metastasis and prolonged the survival of osteosarcoma-bearing mice. Furthermore, in a clinical study, high expression levels of CD133 and miR-133a were significantly correlated with poor prognosis, whereas high expression levels of the four miR-133a target genes were correlated with good prognosis. Overall, silencing of miR-133a with concurrent chemotherapy would represent a novel strategy that targets multiple regulatory pathways associated with metastasis of the malignant cell population within osteosarcoma. Stem Cells 2014;32:959–973
Fatigue life of RC beams strengthened with FRP systems
Authors: Meneghetti Leila Cristina , Garcez Mônica Regina , da Silva Filho Luiz Carlos Pinto , Gastal Francisco de Paula Simões Lopes , Bittencourt Túlio Nogueira 
Published: December 2013

AbstractFibre‐reinforced polymers (FRP) in the form of externally bonded reinforcement have been used successfully in the rehabilitation of concrete structures. Although considerable data has been produced on the performance of strengthened RC structures, the reliability of strengthened structures can be significantly reduced due to the variability in the FRP properties, especially when the wet layup technique is used. In addition to this, structural engineers are concerned about the durability of FRP‐strengthened structures under extreme loading conditions. Nonetheless, knowledge of the behaviour of strengthened elements under fatigue loading may be important to raise confidence in the strengthening systems. This paper presents the results of an experimental programme developed to investigate the behaviour up to failure of RC beams strengthened with high‐performance carbon and aramid fibre sheets and subjected to static and cyclic loadings in terms of ultimate loads, deflections, cracking behaviour, failure modes and fatigue life by means of loading, crack width and deflection monitoring. Experimental data on fatigue life were used to validate analytical models developed for strengthened and unstrengthened beams.
Residual modulus of elasticity and maximum compressive strain in HSC and FRHSC after high‐stress‐level cyclic loading
Authors: Vicente Miguel A. , González Dorys C. , Mínguez Jesús , Martínez José A. 
Published: December 2013

AbstractThis paper discusses the residual modulus of elasticity of and maximum compressive strain in high‐strength concrete (HSC) and fibre‐reinforced high‐strength concrete (FRHSC) after being subjected to axial high‐stress‐level cyclic loading. The paper presents a specific procedure for evaluating the residual values of these mechanical parameters of concrete specimens.This procedure reveals that there is no monotonic decrease in the residual modulus of elasticity with number of cycles; an initial decrease occurs in all cases, followed by an increase and, finally, another decrease. Similarly, there is no monotonic increase in the residual maximum compressive strain.The results show substantial changes in both the residual modulus of elasticity of and the residual maximum compressive strain in concrete depending on the number of cycles. These variations are due to the combined action of two concrete phenomena: microcracking and reconsolidation of the concrete microstructure.
Water permeability of concrete under uniaxial tension
Authors: Yuan Yong , Chi Yang 
Published: December 2013

AbstractConcrete structures can suffer from water permeating under stresses. This paper investigates the surface water permeability of reinforced concrete elements subjected to uniaxial tension. A testing system was developed to combine a conventional loading machine with a surface permeameter. To eliminate the effect of initial absorption of water, calibration tests were conducted on plain concrete samples with different surface saturated states. The experiment presented is designed to test the surface water permeability of a structural member under uniaxial tension. Specimens were reinforced centrally with different sizes of steel bar and fabricated with normal‐strength and high‐strength concrete. A uniaxial tensile load was applied from 0.10 to 0.80 of estimated ultimate cracking load in 0.10 increments. At the same time, water permeability was measured at each load step. Test results give the relationship between water permeability of concrete member and tensile load levels.
Turbine‐scale wind field measurements using dual‐Doppler lidar
Authors: Newsom Rob K. , Berg Larry K. , Shaw William J. , Fischer Marc L. 
Published: December 2013

AbstractSpatially resolved measurements of microscale winds are retrieved using scanning dual‐Doppler lidar and then compared with independent in situ wind measurements. Data for this study were obtained during a month‐long field campaign conducted at a site in north‐central Oklahoma in November of 2010. Observational platforms include one instrumented 60 m meteorological tower and two scanning coherent Doppler lidars. The lidars were configured to perform coordinated dual‐Doppler scans surrounding the 60 m tower, and the resulting radial velocity observations were processed to retrieve the three‐component velocity vector field on surfaces defined by the intersecting scan planes. The dual‐Doppler analysis method is described, and three‐dimensional visualizations of the retrieved fields are presented.The retrieved winds are compared with sonic anemometer (SA) measurements at the 60 m level on the tower. The Pearson correlation coefficient between the retrievals and the SA wind speeds was greater than 0.97, and the wind direction difference was very small (<0.1o), suggesting that the dual‐Doppler technique can be used to examine fine‐scale variations in the flow. However, the mean percent difference between the SA and dual‐Doppler wind speed was approximately 15%, with the SA consistently measuring larger wind speeds. To identify the source of the discrepancy, a multi‐instrument intercomparison study was performed involving lidar wind speeds derived from standard velocity‐azimuth display (VAD) analysis of plan position indicator scan data, a nearby 915 MHz radar wind profiler (RWP) and radiosondes. The lidar VAD, RWP and radiosondes wind speeds were found to agree to within 3%. By contrast, SA wind speeds were found to be approximately 14% larger than the lidar VAD wind speeds. These results suggest that the SA produced wind speeds that were too large. Copyright © 2013 John Wiley & Sons, Ltd.
Can the pollination biology and floral ontogeny of the threatened Acacia carneorum explain its lack of reproductive success?
Authors: Gilpin Amy‐Marie , Ayre David J. , Denham Andrew J. 
Published: December 2013

AbstractMany Acacia species in arid areas of eastern Australia have been severely impacted by grazing, habitat degradation and fragmentation. These factors have been at the core of proposed explanations for the reproductive failure and numerical decline of Acacia carneorum and other threatened acacias. Paradoxically, the sympatric Acacia ligulata is thriving and highly fecund. Although these species have superficially similar floral displays, differences in sexual reproductive success may reflect interactions between flower and inflorescence ontogeny and pollinator assemblages. We compared the floral biology and flower visitor assemblages of A. carneorum and A. ligulata at four sites per species. Both species displayed similar floral ontogeny and synchronicity of display, with inflorescences simultaneously hermaphroditic for 4–5 days. However, A. ligulata displayed a higher density of flowers than A. carneorum and, while both species received a range of flower visitors, A. ligulata was visited by relatively few species and was serviced primarily by the non‐native honeybee Apis mellifera, which typically made many within‐plant movements during foraging bouts. In contrast, A. carneorum was visited by a diverse suite of native insects that carried little pollen and made fewer within plant movements. On average, Apis mellifera carried 98.4 % A. ligulata pollen, whereas the native insect visitors of A. carneorum carried only 45 % A. carneorum pollen. Differing floral ontogeny or lack of native pollinators does not explain the reproductive failure of A. carneorum. The success of A. ligulata may reflect pollination services provided by A. mellifera and interactions with plant mating systems.
Exact Equations for SIR Epidemics on Tree Graphs
Authors: Sharkey K. J. , Kiss I. Z. , Wilkinson R. R. , Simon P. L. 
Published: December 2013

AbstractWe consider Markovian susceptible-infectious-removed (SIR) dynamics on time-invariant weighted contact networks where the infection and removal processes are Poisson and where network links may be directed or undirected. We prove that a particular pair-based moment closure representation generates the expected infectious time series for networks with no cycles in the underlying graph. Moreover, this “deterministic” representation of the expected behaviour of a complex heterogeneous and finite Markovian system is straightforward to evaluate numerically.
The vibrations induced by surface irregularities in road pavements – a Matlab® approach
Authors: Agostinacchio M. , Ciampa D. , Olita S. 
Published: December 2013

Abstract

Purpose
The paper tackles the theme of evaluating dynamic load increases that the vehicle transfers to the road pavement, due to the generation of vibration produced by surface irregularities.

Method
The study starts from the generation, according to the ISO 8608 Standard, of different road roughness profiles characterized by different damage levels. In particular, the first four classes provided by ISO 8608 were considered. Subsequently, the force exchanged between the pavement and three typologies of vehicles (car, bus and truck) has been assessed by implementing, in Matlab®, the QCM (Quarter Car Model) characterized by a quarter vehicle mass and variable speed from 20 to 100 km/h. The analysis allows determining the amount of dynamic overload that causes the vibrational stress.

Results/Conclusions
The paper shows how this dynamic overload may be predetermined as a function of the pavements surface degradation. This is a useful reference for the purposes of designing and maintaining road pavements.
The carcinoembryonic antigen IgV‐like N domain plays a critical role in the implantation of metastatic tumor cells
Authors: Abdul-Wahid Aws , Huang Eric H.-B. , Cydzik Marzena , Bolewska-Pedyczak Eleonora , Gariépy Jean 
Published: December 2013

The human carcinoembryonic antigen (CEA) is a cell adhesion molecule involved in both homotypic and heterotypic interactions. The aberrant overexpression of CEA on adenocarcinoma cells correlates with their increased metastatic potential. Yet, the mechanism(s) by which its adhesive properties can lead to the implantation of circulating tumor cells and expansion of metastatic foci remains to be established. In this study, we demonstrate that the IgV‐like N terminal domain of CEA directly participates in the implantation of cancer cells through its homotypic and heterotypic binding properties. Specifically, we determined that the recombinant N terminal domain of CEA directly binds to fibronectin (Fn) with a dissociation constant in the nanomolar range (KD 16 ± 3 nM) and interacts with itself (KD 100 ± 17 nM) and more tightly to the IgC‐like A3 domain (KD 18 ± 3 nM). Disruption of these molecular associations through the addition of antibodies specific to the CEA N or A3B3 domains, or by adding soluble recombinant forms of the CEA N, A3 or A3B3 domains or a peptide corresponding to residues 108–115 of CEA resulted in the inhibition of CEA‐mediated intercellular aggregation and adherence events in vitro. Finally, pretreating CEA‐expressing murine colonic carcinoma cells (MC38.CEA) with rCEA N, A3 or A3B3 modules blocked their implantation and the establishment of tumor foci in vivo. Together, these results suggest a new mechanistic insight into how the CEA IgV‐like N domain participates in cellular events that can have a macroscopic impact in terms of cancer progression and metastasis.
Subharmonic capillary–gravity waves in large containers subject to horizontal vibrations
Authors: Perez-Gracia José M. , Porter Jeff , Varas Fernando , Vega José M. 
Published: December 2013

AbstractThis paper deals with nearly inviscid, capillary–gravity, modulated waves parametrically excited by monochromatic horizontal vibrations in liquid containers whose width and depth are both large compared with the wavelength of the excited waves. A general linear amplitude equation is derived with appropriate boundary conditions that provides the threshold acceleration and associated spatiotemporal patterns, which compare very well with experimental measurements and visualizations. The primary instability is associated with a pair of complex Floquet multipliers that are close to (but strictly different from) −1, meaning that the instability is not strictly (2:1) subharmonic. The resulting (quasi-periodic) waves are generally oblique, not perpendicular to the vibrating endwalls. The extension of the theory to other confined systems such as vibrating containers of arbitrary shape and vibrating drops is also considered.
Extended series solutions and bifurcations of the Dean equations
Authors: Boshier F. A. T. , Mestel A. J. 
Published: December 2013

AbstractSteady, incompressible flow down a slowly curving circular pipe is considered. Both real and complex solutions of the Dean equations are found by analytic continuation of a series expansion in the Dean number, $K$. Higher-order Hermite–Padé approximants are used and the results compared with direct computations using a spectral method. The two techniques agree for large, real $K$, indicating that previously reported asymptotic behaviour of the series solution is incorrect, and thus resolving a long-standing paradox. It is further found that a second solution branch, known to exist at high Dean number, does not appear to merge with the main branch at any finite $K$, but appears rather to bifurcate from infinity. The convergence of the series is limited by a square-root singularity on the imaginary $K$-axis. Four complex solutions merge at this point. One corresponds to an extension of the real solution, while the other three are previously unreported. This bifurcation is found to coincide with the breaking of a symmetry property of the flow. On one of the new branches the velocity is unbounded as $K\rightarrow 0$. It follows that the zero-Dean-number flow is formally non-unique, in that there is a second complex solution as $K\rightarrow 0$ for any non-zero $\vert K\vert $. This behaviour is manifested in other flows at zero Reynolds number. The other two complex solutions bear some resemblance to the two solution branches for large real $K$.
The effect of irradiation and mass rearing on the anti-predator behaviour of the Mexican fruit fly, Anastrepha ludens (Diptera: Tephritidae)
Authors: Rao D. , Aguilar-Argüello S. , Montoya P. , Díaz-Fleischer F. 
Published: December 2013

AbstractFruit flies (Diptera: Tephritidae) are major pests worldwide. The sterile insect technique, where millions of flies are reared, sterilized by irradiation and then released, is one of the most successful and ecologically friendly methods of controlling populations of these pests. The mating behaviour of irradiated and non-irradiated flies has been compared in earlier studies, but there has been little attention paid to the anti-predator behaviour of mass-reared flies, especially with respect to wild flies. Tephritid flies perform a supination display to their jumping spider predators in order to deter attacks. In this study, we evaluated the possibility of using this display to determine the anti-predator capabilities of mass-reared irradiated, non-irradiated flies, and wild flies. We used an arena setup and observed bouts between jumping spiders (Phidippus audax Hentz) and male Mexican fruit flies (Anastrepha ludens Loew). We show that although all flies performed a supination display to their predator, wild flies were more likely to perform a display and were significantly more successful in avoiding attack than mass-reared flies. We suggest that this interaction can be used to develop a rapid realistic method of quality control in evaluating anti-predator abilities of mass-reared fruit flies.
Influence of micellar calcium and phosphorus on rennet coagulation properties of cows milk
Authors: Malacarne Massimo , Franceschi Piero , Formaggioni Paolo , Sandri Sandro , Mariani Primo , Summer Andrea 
Published: December 2013

The main requirement for milk processed in most cheese typologies is its rennet coagulation ability. Despite the increasing number of studies, the causes for abnormal coagulation of milk are not fully understood. The aim of this study was to ascertain relationships between milk characteristics and its rennet coagulation ability, focusing on the influence of calcium (Ca) and phosphorus (P). Ca and P are essential constituents of the micelles. Micellar P can be present as part of colloidal calcium phosphate (inorganic-P) or covalently bound to caseins as phosphate groups (casein-P). Eighty one herd milk samples (SCC<400 000 cell/ml) were classified as Optimal (8), Suboptimal (39) Poor (29) and Non-coagulating milk (5), according to their rennet coagulation parameters as assessed by lactodynamographic test. Samples were analysed for their chemical composition (basic composition, protein fractions, minerals and salt equilibria), physicochemical parameters (pH and titratable acidity) and rheological properties. Optimal milk was characterised by the highest contents of major constituents, protein fractions and minerals, lowest content of chloride and highest values of titratable acidity. Non-coagulating milk was characterised by the highest values of pH and the lowest of titratable acidity. At micellar level, Optimal milk showed the highest values of colloidal Ca, casein-P and colloidal Mg (g/100 g casein), while Non-coagulating milk showed the lowest values. Interestingly, there was no statistical difference regarding the content of colloidal inorganic-P (g/100 g casein) between Optimal and Non-coagulating milks. Overall, high mineralisation of the micelle (expressed as g inorganic-P/100 g casein) positively affect its rennetability. However, excessive mineralisation could lead to a reduction of the phosphate groups (g casein-P/100 g casein) available for curd formation.
Synthesis and X-ray diffraction data of 4-benzyloxy-1-oxaspiro-[4.6]-undec-3-en-2-one
Authors: Quintana Jose H. , Henao J. A. , Robles Elvis , Urbina Juan Manuel 
Published: December 2013

The 4-benzyloxy-1-oxaspiro-[4.6]-undec-3-en-2-one (C17H20O3) was prepared through a domino reaction from benzyl α-hydroxycycloheptanecarboxylate and the cumulated ylide Ph3P=C=C=O by: (i) addition and (ii) intramolecular Wittig Olefination reaction. The reaction was carried out using anhydrous toluene as solvent under an argon atmosphere in a Schlenk flask. Molecular characterization was performed by Fourier transform infrared spectroscopy, gas chromatography-mass spectrometry, (1H,13C – mono and bidimensional) nuclear magnetic resonance spectroscopy; crystallographic characterization was completed by X-ray diffraction of polycrystalline samples (XRPD). The title compound crystallized in a monoclinical system and unit-cell parameters are reported [a = 13.207(3) Å, b = 5.972(1) Å, c = 19.719(4) Å, β = 105.67(2)°, unit-cell volume V = 1497.5 (4) Å3, Z = 4]. All of the measured lines were indexed with the P21/n (No. 14) space group.
The spread of drug-resistant tuberculosis in children: an Italian case series
Authors: MIGNONE F. , CODECASA L. R. , SCOLFARO C. , RAFFALDI I. , LANCELLA L. , FERRARESE M. , GARAZZINO S. , MARABOTTO C. , ESPOSITO S. , GABIANO C. , LIPRERI R. , TOVO P.-A. 
Published: December 2013

SUMMARYDrug-resistant paediatric tuberculosis (TB) is an overlooked global problem. In Italy, the epidemiology of TB has recently changed and data regarding drug-resistant forms in the paediatric setting is scanty. The aim of this case series was to report the cases of drug-resistant TB, diagnosed between June 2006 and July 2010 in four Italian tertiary centres for paediatric infectious diseases, in children and adolescents living in Italy. Twenty-two children were enrolled, of these 17 were resistant to one or more drugs and five had multidrug-resistant TB. All but one child were either foreign born or had at least one foreign parent. Twenty-one patients completed their treatment without clinical or radiological signs of activity at the end of treatment, and one patient was lost to follow up. The outcomes were good, with few adverse effects using second-line anti-TB drugs. Although this series is limited, it might already reflect the worrisome increase of drug-resistant TB, even in childhood.