bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anticancer Properties of a Novel Class of Tetrafluorinated Thalidomide Analogues
Authors: Beedie Shaunna L. , Peer Cody J. , Pisle Steven , Gardner Erin R. , Mahony Chris , Barnett Shelby , Ambrozak Agnieszka , Gütschow Michael , Chau Cindy H. , Vargesson Neil , Figg William D. 
Published: August 2015

Abstract
Thalidomide has demonstrated clinical activity in various malignancies affecting immunomodulatory and angiogenic pathways. The development of novel thalidomide analogs with improved efficacy and decreased toxicity is an ongoing research effort. We recently designed and synthesized a new class of compounds, consisting of both tetrafluorinated thalidomide analogues (Gu973 and Gu998) and tetrafluorobenzamides (Gu1029 and Gu992). In this study, we demonstrate the antiangiogenic properties of these newly synthesized compounds. We examined the specific antiangiogenic characteristics in vitro using rat aortic rings with carboxyamidotriazole as a positive control. In addition, further in vitro efficacy was evaluated using human umbilical vein endothelial cells (HUVEC) and PC3 cells treated with 5 and 10 μmol/L doses of each compound. All compounds were seen to reduce microvessel outgrowth in rat aortic rings as well as to inhibit HUVECs to a greater extent, at lower concentrations than previously tested thalidomide analogs. The antiangiogenic properties of the compounds were also examined in vivo in fli1:EGFP zebrafish embryos, where all compounds were seen to inhibit the extent of outgrowth of newly developing blood vessels. In addition, Gu1029 and Gu973 reduced the anti-inflammatory response in mpo:GFP zebrafish embryos, whereas Gu998 and Gu992 showed no difference. The compounds' antitumor effects were also explored in vivo using the human prostate cancer PC3 xenograft model. All four compounds were also screened in vivo in chicken embryos to investigate their teratogenic potential. This study establishes these novel thalidomide analogues as a promising immunomodulatory class with anticancer effects that warrant further development to characterize their mechanisms of action. Mol Cancer Ther; 14(10); 2228–37. ©2015 AACR.
Continuous Amplitude-Integrated Electroencephalographic Monitoring Is a Useful Prognostic Tool for Hypothermia-Treated Cardiac Arrest Patients
Authors: Oh Sang Hoon , Park Kyu Nam , Shon Young-Min , Kim Young-Min , Kim Han Joon , Youn Chun Song , Kim Soo Hyun , Choi Seung Pill , Kim Seok Chan 
Published: August 2015

Background—
Modern treatments have improved the survival rate following cardiac arrest, but prognostication remains a challenge. We examined the prognostic value of continuous electroencephalography according to time by performing amplitude-integrated electroencephalography on patients with cardiac arrest receiving therapeutic hypothermia.

Methods and Results—
We prospectively studied 130 comatose patients treated with hypothermia from September 2010 to April 2013. We evaluated the time to normal trace (TTNT) as a neurological outcome predictor and determined the prognostic value of burst suppression and status epilepticus, with a particular focus on their time of occurrence. Fifty-five patients exhibited a cerebral performance category score of 1 to 2. The area under the curve for TTNT was 0.97 (95% confidence interval, 0.92–0.99), and the sensitivity and specificity of TTNT<24 hours after resuscitation as a threshold for predicting good neurological outcome were 94.6% (95% confidence interval, 84.9%–98.9%) and 90.7% (95% confidence interval, 81.7%–96.2%), respectively. The threshold displaying 100% specificity for predicting poor neurological outcome was TTNT>36 hours. Burst suppression and status epilepticus predicted poor neurological outcome (positive predictive value of 98.3% and 96.4%, respectively). The combination of these factors predicted a negative outcome at a median of 6.2 hours after resuscitation (sensitivity and specificity of 92.0% and 96.4%, respectively).

Conclusions—
A TTNT<24 hours was associated with good neurological outcome. The lack of normal trace development within 36 hours, status epilepticus, and burst suppression were predictors of poor outcome. The combination of these negative predictors may improve their prognostic performance at an earlier stage.
Object-Based Evaluation of a Numerical Weather Prediction Model’s Performance through Forecast Storm Characteristic Analysis
Authors: Cai Huaqing , Dumais Robert E. 
Published: August 2015

AbstractTraditional pixel-versus-pixel forecast evaluation scores such as the critical success index (CSI) provide a simple way to compare the performances of different forecasts; however, they offer little information on how to improve a particular forecast. This paper strives to demonstrate what additional information an object-based forecast evaluation tool such as the Method for Object-Based Diagnostic Evaluation (MODE) can provide in terms of assessing numerical weather prediction models’ convective storm forecasts. Forecast storm attributes evaluated by MODE in this paper include storm size, intensity, orientation, aspect ratio, complexity, and number of storms. Three weeks of the High Resolution Rapid Refresh (HRRR) model’s precipitation forecasts during the summer of 2010 over the eastern two-thirds of the contiguous United States were evaluated as an example to demonstrate the methodology. It is found that the HRRR model was able to forecast convective storm characteristics rather well either as a function of time of day or as a function of storm size, although significant bias does exist, especially in terms of storm number and storm size. Another interesting finding is that the model’s ability of forecasting new storm initiation varies substantially by regions, probably as a result of its different skills in forecasting convection driven by different forcing mechanisms (i.e., diurnal heating vs synoptic-scale frontal systems).
Doctors discussing religion and spirituality: A systematic literature review
Authors: Best Megan , Butow Phyllis , Olver Ian 
Published: August 2015

Background: Discussion of religion and/or spirituality in the medical consultation is desired by patients and known to be beneficial. However, it is infrequent. We aimed to identify why this is so. Aim: We set out to answer the following research questions: Do doctors report that they ask their patients about religion and/or spirituality and how do they do it? According to doctors, how often do patients raise the issue of religion and/or spirituality in consultation and how do doctors respond when they do? What are the known facilitators and barriers to doctors asking their patients about religion and/or spirituality? Design: A mixed qualitative/quantitative review was conducted to identify studies exploring the physician’s perspective on discussion of religion and/or spirituality in the medical consultation. Data sources: We searched nine databases from inception to January 2015 for original research papers reporting doctors’ views on discussion of religion and/or spirituality in medical consultations. Papers were assessed for quality using QualSyst and results were reported using a measurement tool to assess systematic review guidelines. Results: Overall, 61 eligible papers were identified, comprising over 20,044 physician reports. Religion and spirituality are discussed infrequently by physicians although frequency increases with terminal illness. Many physicians prefer chaplain referral to discussing religion and/or spirituality with patients themselves. Such discussions are facilitated by prior training and increased physician religiosity and spirituality. Insufficient time and training were the most frequently reported barriers. Conclusion: This review found that physician enquiry into the religion and/or spirituality of patients is inconsistent in frequency and nature and that in order to meet patient needs, barriers to discussion need to be overcome.
Tracheostomy procedures in the intensive care unit: an international survey
Authors: Vargas Maria , Sutherasan Yuda , Antonelli Massimo , Brunetti Iole , Corcione Antonio , Laffey John G. , Putensen Christian , Servillo Giuseppe , Pelosi Paolo 
Published: August 2015

Abstract
Introduction
Percutaneous dilatational tracheostomy (PDT) is one of the most frequent procedures performed in the intensive care unit (ICU). PDT may add potential benefit to clinical management of critically ill patients. Despite this, no clinical guidelines are available. We sought to characterize current practice in this international survey.

Methods
An international survey, endorsed and peer reviewed by European Society of Intensive Care Medicine (ESICM), was carried out from May to October 2013. The questionnaire was accessible from the ESICM website in the ‘survey of the month’ section.

Results
429 physicians from 59 countries responded to this survey. Single step dilatational tracheostomy was the most used PDT in ICU. Almost 75 % of PDT’s were performed by intensive care physicians. The main indication for PDT was prolonged mechanical ventilation. Tracheostomies were most frequently performed between 7–15 days after ICU admission. Volume control mechanical ventilation, and a combination of sedation, analgesia, neuromuscular blocking agents and fiberoptic bronchoscopy were used. Surgical tracheostomy was mainly performed in ICU by ENT specialists, and was generally chosen when for patients at increased risk for difficult PDT insertion. Bleeding controlled by compression and stoma infection/inflammation were the most common intra-procedural and late complications, respectively. Informed consent for PDT was obtained in only 60 % of cases.

Conclusions
This first international picture of current practices in regard to tracheostomy insertion demonstrates considerable geographic variation in practice, suggesting a need for greater standardization of approaches to tracheostomy insertion.
Test Quality Analysis during Specialist Certification on Acoustic Emission Nondestructive Testing of Railway Objects
Authors: Платунов  , Platunov Andrey , Богдан  , Bogdan Olga , Волкова  , Volkova Lyudmila , Муравьёва  , Muraveva Olga , Муравьёв  , Muravev Vitaliy , Байкалова  , Baykalova Tatyana 
Published: August 2015

The results of qualification exams during specialist certification on acoustic emission nondestructive testing of railway objects are analyzed. The correspondence of task test difficulty with the level of specialist preparedness for certification is considered using the Rush method. Analysis of test results in specialist certification has shown:
- the presence of the deviation in the distribution of test task difficulty level histograms from the uniform law, especially for special exam tests, that requires the elimination of the tasks with very low and very high difficulty level logits, as well as increasing the number of the tasks with the minimum function of task test difficulty logit;
- the necessity of training intensification in the test topics corresponding to minimum specialist preparedness logits.
The obtained results are the bases for following analyses of the test task difficulty; the reasons of insufficient learning topic tasks with a low percentage of answer; making the possible adjustments in the consulting sessions, as well as the content and form of the test.
To exclude the test bias, the interview with certified specialist is carried out in examination center allowing specifying whether the specialist knows the basic concepts and has acoustic emission testing technology skills.
In general the performed analysis showed a high preparedness degree for most specialists due to regular training and at least a year work experience on acoustic emission testing.
DECISION-MAKING WITH MULTIPLE CRITERIA IN THE SELECTION OF ULTRASONIC SCANNING SYSTEM IN A PRIVATE HOSPITAL IN BRAZIL
Authors: Montevechi Jose , Guimaraes Italo Freire , De Oliveira Mona Liza Moura , Friend Jonathan Daniel 
Published: August 2015

<p>This article presents the Analytical Hierarchy Process (AHP) as an aiding approach in decision-making, applied to the technical evaluation of the acquisition process of ultrasonic device in a private hospital in Brazil. Some steps and principles of AHP, such as the complexity of hierarchical decomposition, comparative judgments, priorities synthesis, and sensitivity analysis show, themselves to be utilities for the success of the technical evaluation process, going from meeting the hospital’s necessity for transparency to auditable process documentation. The hospital’s management’s expectation of separating the hospital’s medical technical evaluation process from the commercial evaluation process was achieved through the application of AHP. Despite the great number of possible variables for the ultra-sound’s technical evaluation, the decision-making team adapted itself easily and quickly to the employed method, contributing to the success of the work. The range of medical equipment installed in Brazil presents geographic concentration, with a large percentage of the equipment remaining unused due to lack of maintenance or inadequate staff to operate them, and the quantity of determined image devices per habitant above the average of other developed countries. That reality leads to the waste of resources in the health sector and adverse effects to the population’s health. This confirms the pertinence of the instrument’s application in this work, and indicates the potential increase in its utilization in the planning and control of public and private resources in the health sector.</p><p> </p><p>http://dx.doi.org/10.13033/ijahp.v2i1.70</p>
DETERMINATION OF THE MOST APPROPRIATE POLICY FOR RIVER BASIN MANAGEMENT
Authors: Sabiá Rodolfo J. , Salomon Valerio A. P. , Sobreira Júnior Francisco A. V. , Marins Fernando A. S. , Lima Anna F. O. 
Published: August 2015

<p class="MsoNormal" style="text-align: justify;"><span style="font-size: 11.0pt;">The Parliament of the Salgado River provided actions and recommendations for the future of the Salgado River Basin which is in the south of Ceara State, Brazil. These recommendations were obtained through a democratic process, with the involvement of around 100 participants from private companies, public organizations and the third sector. The intention was to define a model that is compatible with the aspirations of society regarding the use and quality of the water, as well as define necessary decision actions and strategies. The main goal of this article is to determine, with a multi-criteria decision analysis, an appropriate policy for the river basin management. Therefore, the Analytic Hierarchy Process (AHP) was applied. The criteria are a combination of economic, environmental, and social issues; the alternatives were defined as essentially preservationist policy, sustainable policy, and essentially economic policy. The AHP application was effective in this decision analysis.</span></p><div><div><div id="_com_2" class="msocomtxt"><!--[if !supportAnnotations]--></div><!--[endif]--></div></div><div id="_mcePaste" class="mcePaste" style="left: -10000px; top: 16px; width: 1px; height: 1px; overflow: hidden; position: absolute;"> </div>
AN MCDM APPROACH TOWARDS M-PAYMENT BUSINESS MODELS EVALUATION
Authors: Ali Abid 
Published: August 2015

<p>There are many challenges in the adaptation of m-payment technology such as improved service quality, missing standards, lack of content quality, low customer satisfaction, and lack of a business model. The business model plays a critical role in the success of m-payment technology, and there are different m-payment business models, each with their own advantages and disadvantages. Project managers have little understanding about the different components of these specific business models. This study surveyed different business model’s evaluation criteria from the literature and industry, and used the Analytic Hierarchy Process to evaluate m-payment business models on the basis of these criteria. The scalability and user centric architecture in the case of service related factors and collaboration &amp; partnership, and response to market trends were the most important factors for sustainability of business models. According to the given criteria, the collaboration model was the most dominant model in the m-commerce domain. A sensitivity analysis was performed in order to find out different views about the final prioritized list under varying conditions.</p>
Inclusiveness through art films in Telugu: A modern to postmodern analysis of K. Viswanath’s films
Authors: Murthy C. S. H. N. 
Published: August 2015

Abstract
This present study attempts to situate the themes of Kasinadhuni Viswanath’s (popularly known as K.Viswanath in Telugu film industry) musicals in modernist and postmodernist cultural perspectives in an effort to show that art forms such as music, song and dance are of immense help for a silent and non-violent social revolution that subsumes the ‘inclusiveness’ besides ushering in harmony in society. Viswanath’s films are synonymous with the repertory of music and dance forms in India. Known for his artistry in combining music, song and dance together, Viswanath’s reputed and award winning film – Sankarabharanam (1979) – has not only won national recognition as the best entertaining wholesome popular film, but also offered explorable alternatives to eliminate social evils such as economic and caste disparities, and the misconceptions such as, western music is superior over eastern music, western life is greater than traditional Indian life, etc. Viswanath is perhaps one of the rarest directors of the Indian film industry who dared to produce a different genre of films, both in Telugu and Hindi, combining music and dance forms against the background of social or traditional issues for national integration (e.g. Saptapadi 1981). Using the moving image and analysis of Kracauer, this study heuristically offers evidence to show how his musicals have effectively used a ‘social model’ akin to a ‘Gandhian model’ through a unique combination of signs, symbols and philosophical ideas of traditional Indian culture with the art forms – music, song and dance styles. Further the study endeavours to show how Viswanath develops conflicts first at the modernist level between the Proppian elements in his plots in the narratives, and how through a deft manoevouring of the narratives these conflicts culminate into solutions suggestive of ‘inclusiveness’.
Professorial and academic reflections 2: Carla Walter interviewed by Amanda Williamson
Authors: Walter Carla Stalling 
Published: August 2015

Abstract
Dr Carla Walter recently published her book ‘Dance, Consumerism and Spirituality’ with Palgrave Macmillan. It was fascinating to me that both her book and my co-edited book, ‘Dance Somatics and Spiritualities: Contemporary Sacred Narratives’ arrived on the bookshelf at around the same – very different, yet complimentary texts, expanding the spiritual horizon in Dance Studies in the contemporary milieu. Here we interweave some ideas and we explore together aspects of her book, and some further issues in relation to dance and spirituality as a developing area of research and teaching in higher education.
Book Reviews
Authors: LaMothe Kimerer L , Oberem Maria Luise 
Published: August 2015

Abstract
Seiki Jutsu: The Practice of Non-Subtle En ergy Medicine, B. KEENEY AND H. KEENEY (2014), Rochester, VT: Healing Arts Press, 216 pp., ISBN 9781620554326, p/bk, $16.95
Dance, Somatics and Spiritualities: Contemporary Sacred Narratives, A. Williamson (ed.) (2014), Bristol: Intellect, 489 pp., print, ISBN: 978-1-78320-178-5, £47.00
At home, I’m a tourist: Musical migration and affective citizenship in Berlin
Authors: Garcia Luis-Manuel 
Published: August 2015

Abstract
This article explores the ways in which musical, sonic, and more broadly sensory experiences of Berlin provide the ground for an ambivalent sense of civic belonging for a cadre of migrants affiliated with the city’s local electronic dance music scenes. Drawn from ethnographic fieldwork, the accounts of these ‘techno migrants’ articulate an identification with the local music scenes, the built environment of the city, its urban soundscapes, its pace of life, its low population-density, its socio-economic and multicultural mix, the attitudes and sartorial styles of its residents, and the palpable sense of both recent history and imminent future. The affective dimensions of these identifications provide a means of sustaining a fantasy of belonging to a place where one remains foreign, relying on immersion in and identification with the city’s atmospheres to hold in abeyance the alienating aspects of migration. Thus, the feeling of being ‘at home’ in Berlin stands in for other modes of civic belonging (e.g., legal, ethnic, cultural) to which techno-migrants have limited or obstructed access. These musical migrants seem to engage in a form of ‘affective citizenship’ (Berlant 1997; Jones 2001; Mookherjee 2005), where a sense of belonging is sustained through affective experiences that index belonging, sometimes regardless of whether such belonging has juridical or social recognition.
Cape Town and the sustainable city in the writing of Henrietta Rose-Innes
Authors: Kruger Loren 
Published: August 2015

Abstract
In narratives that demonstrate the mutual imbrication of urban and ecological imperatives, Henrietta Rose-Innes complements planners’ work that analyses and strives to sustains human and other native and migrating species in Cape Town. Squeezed between cliffs and oceans, urban life here must deal with mountain topography that appears to escape development and with environments that seem to frustrate civic order, particularly the informal settlements on the edges of this cosmopolitan tourist port. Drawing on anti-apartheid tropes of social justice and on post-apartheid challenges to neo-liberal speculation, her fiction and non-fiction writing traces the steps of biped, quadruped and hexapod figures along the borders between habitation and wilderness, urban street and bare earth to capture the beauty and violence of this singular South African city.
Public art practice and urban change: An interview with public art activist Jack Becker
Authors: Pollock Venda Louise , Sharp Joanne 
Published: August 2015

Abstract
In 2014 Jack Becker was the recipient of the Public Art Dialogue Award in recognition of his contributions to the field of public art. Becker is the executive director of Forecast Public Art, which he established in 1978, and publisher of Public Art Review. Building on Becker’s education in the arts and career experience as an Art in Public Places programme coordinator (Minneapolis) and Arts Development manager (St Paul), Forecast Public Art has developed into a non-profits arts organization that seeks to connect ‘the energies and talents of artists with the needs and opportunities of communities’ and works closely with artists, stakeholders and communities to develop and realize projects responding to their needs.
Text to street: Urban cultural studies as theorization and practice
Authors: Masterson-Algar Araceli , Vilaseca Stephen Luis 
Published: August 2015

Abstract
This editorial questions the accepted view among militant researchers in the academy and radical activists outside of it that activism is not possible within higher education. The notion that theory is not practice fails to see that humanistic enquiry does not take place outside of material reality. Thinking and doing cannot be compartmentalized. They form part of greater cultural processes. This editorial argues that research and courses addressing urban cultural studies can offer the space to imagine activism both inside and outside our classrooms and institutions.