bluuebunny/crossref_metadata_2025_split huggingface dataset:
Assessing cardiac mechanics through left ventricular haemodynamic forces
Authors: Aimo Alberto , Panichella Giorgia , Fabiani Iacopo , Garofalo Manuel , Fanizzi Angela Ilaria , Ragagnin Maddalena , Milazzo Alessandra , Zocchi Chiara , Del Franco Annamaria , Pedrizzetti Gianni , Olivotto Iacopo , Emdin Michele 
Published: July 2024

Abstract
Haemodynamic forces (HDFs), which represent the forces exchanged between blood and surrounding tissues, are critical in regulating the structure and function of the left ventricle (LV). These forces can be assessed on cardiac magnetic resonance or transthoracic echocardiography exams using specialized software, offering a non-invasive alternative for measuring intraventricular pressure gradients. The analysis of HDFs can be a valuable tool in improving our understanding of cardiovascular disease and providing insights beyond traditional diagnostic and therapeutic approaches. For instance, HDF analysis has the potential to identify early signs of adverse remodelling and cardiac dysfunction, which may not be detected by standard imaging methods such as bidimensional or speckle-tracking echocardiography. This review aims to summarize the principles of HDF analysis and to reappraise its possible applications to cardiac disorders.
FAQ: How do I estimate the output gap?
Authors: Canova Fabio 
Published: July 2024

Abstract
I investigate the properties of output gaps in New Keynesian dynamic stochastic general equilibrium models and study the relationship between theory-based quantities and the estimates obtained with standard approaches. Theoretical gaps display low-frequency variations, have similar frequency domain representations as potentials and are generally correlated with them. Potentials have important business cycle variability. Existing statistical approaches fail to recognise these features and generate distorted estimates. Gaps are best estimated with a polynomial filter. Explanations for the outcomes are given. I propose a statistical procedure reducing estimation biases.
Promoting successful healing of artificial trachea by intratracheal administration of basic fibroblast growth factor
Authors: Murata Yoshitake , Yutaka Yojiro , Fukui Takamasa , Hirata Rieko , Ibi Yumiko , Hidaka Yu , Yoshizawa Akihiro , Kishimoto Yo , Omori Koichi , Date Hiroshi 
Published: July 2024

Abstract

OBJECTIVES
This study evaluated the effect of intratracheal administration of basic fibroblast growth factor (bFGF) on tracheal healing following implantation of a novel layered polyglycolic acid (PGA) material to replace a critical-size defect in rat trachea.

METHODS
A critical-size defect in the rat cervical trachea was covered with PGA. Distilled water (DW) or 3.125, 6.25, 12.5 or 25 µg bFGF was administered into the trachea for 2 weeks (n = 6 for each of 5 groups). Regenerated areas of cilia, ciliary beat frequency and ciliary transport function (CTF) in the centre of the PGA were measured. To examine potential side effects of intratracheal administration of bFGF, the right lower lobe was pathologically evaluated.

RESULTS
All rats survived during the study period. Histological examination showed ciliated epithelization on the PGA material after 2 weeks. Bronchoscopy revealed stenosis due to granulation following administration of high concentrations of bFGF (12.5 and 25 µg). Compared with the DW group, groups administered 3.125, 6.25, 12.5 and 25 µg bFGF had significantly larger areas of regenerated cilia (15.2%, 27.0%, 41.3%, 33.1% and 31.0%, respectively; P = 0.00143), improved ciliary beat frequency (7.10, 8.18, 10.10, 9.50 and 9.50 Hz, respectively), and improved CTS (6.40, 9.54, 16.89, 16.41 and 14.29 µm/sec, respectively). Pathological examination of the right lower lobe revealed pulmonary fibrosis and hyperplasia with high concentrations of bFGF (12.5 and 25 µg).

CONCLUSIONS
Intratracheal administration of bFGF effectively promoted tracheal regeneration at an optimal dose of 6.25 µg following implantation of an artificial trachea.
‘Teaching Poetry is Like Having a Liquor Store on a Busy Corner’: An Interview with Robert Pinsky
Authors: Xerri Daniel 
Published: July 2024

Abstract
Three-time Poet Laureate Robert Pinsky is one of the US’ most important contemporary poets. In this interview, he talks about his formation as a poet and the status of poetry in contemporary culture. He also shares his views on the place of poetry in education, and on how teachers can play a vital role in engaging young people with the genre. Besides discussing the significance of the projects he devised as poet laureate, he uses his knowledge and experience as a poet and educator to explain how young people’s engagement with the reading and writing of poetry can best be enhanced.
May Measurement Month 2021: an analysis of blood pressure screening results from Armenia
Authors: Zelveian Parounak , Hakobyan Zoya , Gharibyan Heghine , Melkonyan Arevik , Hayrumyan Samvel , Aroyan Siranush , Hazarapetyan Lusine , Grigoryan Svetlana , Beaney Thomas , Kerr Gabriele , Poulter Neil 
Published: July 2024

Abstract
Elevated blood pressure (BP) is a growing burden worldwide and is the leading cause of mortality and disability-adjusted life years all over the world. May Measurement Month (MMM) is a global initiative aimed to increase awareness of high BP initiated by the International Society of Hypertension, to identify individuals in need of improved hypertension care, and to improve BP screening worldwide. An opportunistic cross-sectional survey of volunteers aged ≥18 years was carried out in accordance with standard MMM protocol in 2021. The study was conducted in public areas, both indoor and outdoor, as well as in primary and secondary healthcare centres. A total of 5777 individuals (mean age 51.8 ± 16.1 years, 49.8% female) were screened. After imputation, 45.7% participants had hypertension and 43.7% of them were aware of their high BP. Of 2640 participants with hypertension, 887 (33.6%) were on antihypertensive treatment, of whom 32.4% were on single medication, 29.7% on two medications, and 37.9% on three or more. Only 42.2% of those on medication had controlled BP (&lt;140/90 mmHg), whereas of the participants with hypertension overall, 14.2% had controlled BP. We found that the prevalence of inadequately treated hypertension remains high in Armenia and may represent a vital contributor to the growing burden of non-communicable diseases.
May Measurement Month 2021: an analysis of blood pressure screening results from Albania
Authors: Draçini Xheladin , Çumashi Rudina , Qirjako Gentiana , Beaney Thomas , Kiru Gaia , Janssen-Telders Carolina , Fico Albana , Burazeri Genc 
Published: July 2024

Abstract
This article describes the May Measurement Month (MMM) 2021 campaign, which was the fourth time this annual hypertension screening campaign was conducted in Albania, a Mediterranean country in southeastern Europe. The MMM21 was conducted during the period of 28 September–30 November 2021, in 32 sites across several districts of Albania. Overall, 11 788 participants aged ≥18 years were included (63% women), with a mean age of 49.7 ± 14.9 years. Blood pressure (BP) was measured three times with Omron sphygmomanometers (model M3, Omron Healthcare, Kyoto, Japan), which are automatic upper arm BP monitors. Hypertension was defined as SBP ≥ 140 mmHg or diastolic blood pressure (DBP) ≥ 90 mmHg (based on the mean of the second and third recordings for SBP and DBP, respectively) or on antihypertensive medication. Self-reported data included pre-existing conditions, physical activity, smoking, alcohol consumption, COVID-19 testing, and use of contraception in women. Overall, 47.3% of screened participants had hypertension. Of those with hypertension, 70.1% were aware of their condition and 67.0% were on antihypertensive medication. About half (49.3%) of participants on antihypertensive medication had controlled BP (&lt;140/90 mmHg). On average, BP was higher in those on antihypertensive medication and with increasing alcohol intake but lower in those with a history of stroke and those with higher levels of physical activity, previous positive COVID-19 test, and contraception use in women. In Albania, the MMM campaign continues to contribute to the early detection of hypertension among adults. Hence, it constitutes a valuable opportunistic screening instrument among other routine tools applied in the general Albanian population.
May Measurement Month 2021: an analysis of blood pressure screening results from Georgia
Authors: Tsinamdzgvrishvili Bezhan , Gamkrelidze Amiran , Trapaidze Dali , Sturua Lela , Grdzelidze Nino , Abesadze Tamar , Mebonia Nana , Giuashvili Nia , Gogilashvili Nino , Chikovani Nino , Beaney Thomas , Kiru Gaia , Toopchiani Sima , Poulter Neil R 
Published: July 2024

Abstract
The annual global May Measurement Month screening campaign initiated by the International Society of Hypertension aims to raise awareness of raised blood pressure (BP) and in the absence of systematic screening is a useful surrogate indicating the size of the problem of hypertension in the general population in Georgia. May Measurement Month screening was carried out at 400 sites in Georgia in 2021, and more than 500 volunteers, including physicians (80%) and medical students (20%), carried out in the screening. Adults aged ≥18 years were recruited opportunistically, and three BP readings were measured, along with a questionnaire collecting information on demographics, lifestyle, and co- morbidities. Hypertension was defined as a systolic BP ≥ 140 mmHg or diastolic BP ≥ 90 mmHg, based on the mean of the second and third readings, or in those on antihypertensive medication. A total of 4935 individuals were screened, with a mean age of 53.6 years (SD 17.1). A total of 2836 (57.5%) were found to have hypertension, of whom 2441 (86.1%) were aware of their condition and 83.5% were on hypertensive medication. Of those on medication, 41.6% had their BP controlled (&lt;140/90 mmHg). Of all participants with hypertension, 34.7% were controlled. May Measurement Month data highlight the scale of hypertension in Georgia, with low rates of control in those on medication. Educational interventions among the population and medical personnel to raise awareness of high BP and improve control rates are of high importance, which require strong advocacy among policy makers.
May Measurement Month 2021: an analysis of blood pressure screening results from Kenya
Authors: Mbau Lilian , Gitura Bernard , Nguchu Hellen , Moraa Yubrine , Samia Bernard , Beaney Thomas , Toopchiani Sima , Poulter Neil R , Ogola Elijah 
Published: July 2024

Abstract
Hypertension is a major contributor to premature death and disability globally. The age-standardized prevalence of hypertension among adults aged 30–79 years is among the highest at 36%. Despite the availability of cost-effective interventions, awareness, treatment, and control rates remain low. To tackle this and raise awareness, the May Measurement Month (MMM) campaign was initiated by the International Society of Hypertension in 2017. This paper summarizes results from the 2021 MMM campaign. Screening was conducted in 22 sites across 7 counties. We aimed to take three blood pressure (BP) readings and corresponding heart rate measurements as per the standardized protocol. Where this was not achievable, at least one reading was taken. Other variables recorded included demographic data, risk factors, comorbidities, and history of COVID-19 infection. A total of 9738 individuals were screened, of whom 57% were female. After multiple imputations, 28.2% were hypertensive, of whom 45.9% were aware and 42.0% were on treatment. Of those on treatment, 50.3% were controlled, translating to control among only 21.1% of the total hypertensive population. Previous COVID-19 vaccinations were associated with lower systolic BP (SBP) and diastolic BP (DBP). Individuals who consumed alcohol one to three times a month had lower diastolic BP after adjustment for age, sex, and anti-hypertensive treatment. Among women, the use of hormonal contraceptives was associated with lower SBP and DBP after adjustment for age, sex, and anti-hypertensive treatment. Hypertension awareness, treatment, and control rates remain low, though trends from previous MMM campaigns in Kenya suggest steady improvement. The associations between COVID-19 vaccination and contraceptive use with lower BP warrant further investigation. Programmes such as MMM provide much needed data to track the progress towards reducing the burden of hypertension.
May Measurement Month 2021: an analysis of blood pressure screening results from Kazakhstan
Authors: Mukhtarkhanova Dilyara , Poulter Neil R , Beaney Thomas , Kiru Gaia , Toopchiani Sima , Junusbekova Gulnara , Tundybayeva Meiramgul Kapsimetovna , Baglanova Lyazat , Leonovich Tatiana , Ismailov Eldar 
Published: July 2024

Abstract
The May Measurement Month (MMM) screening campaign initiated by the International Society of Hypertension aimed to assess the prevalence of hypertension and associated risk factors to increase and improve population awareness of raised blood pressure (BP) and methods of prevention. The MMM is a cross-sectional survey of adults aged 18 years and over of both sexes who gave informed consent to participate in the survey and to have their BP measured. Kazakhstan participated in the campaign for the first time in 2021. Blood pressure was measured three times on a single occasion, and data on cardiovascular risk factors were collected. A total of 1763 respondents from 4 regions participated in the screening. The mean age was 41 ± 14.4 years; 31.5% of all participants were found to have hypertension, of whom 41.8% were aware, 34.0% on treatment, and only 15.8% controlled (&lt;140/90 mmHg). Significant differences in these rates were found between age and sex groups. The screening campaign confirms low levels of awareness of hypertension and associated risk factors in the population in Kazakhstan and the need for annual screening and implementation of national hypertension control programmes.
Leadless pacemaker implantation via the internal jugular vein
Authors: Molitor Nadine , Saleem-Talib Shmaila , Ramanna Hemanth , Hofer Daniel , Breitenstein Alexander , Steffel Jan 
Published: July 2024

Abstract

Aims
Leadless pacemaker therapy was introduced to overcome lead- and pocket-related complications in conventional transvenous pacemaker systems. Implantation via the femoral vein, however, may not always be feasible. The aim of this study was to evaluate leadless pacemaker implantation using a jugular vein approach and compare it to the standard implantation via the femoral vein.

Methods and results
The records of the first consecutive 100 patients undergoing Micra™ leadless pacemaker implantation via the right internal jugular vein from two centres were included in this study. Peri-procedural safety and efficacy of the jugular approach were compared to the first 100 patients using a femoral implantation approach at the University Hospital Zurich. One hundred patients underwent successful implantation of a leadless pacemaker via the internal jugular vein (mean age, 81.18 ± 8.29, 60% males). Mean procedure time was 35.63 ± 10.29 min with a mean fluoroscopy time of 4.66 ± 5.16 min. The device was positioned at the inferior septum in 25 patients, at the high septum in 24 patients, and mid-septum in 51 patients. The mean pacing threshold was 0.56 ± 0.35 V at 0.24 ms pulse width with a sensed amplitude of 10.0 ± 4.4 mV. At follow-up, electrical parameters remained stable in all patients. Compared with femoral implantation, patients undergoing the jugular approach were of similar age and had similar comorbidities. Mean procedure (48.9 ± 21.0 min) and fluoroscopy times (7.7 ± 7.8 min, both P &lt; 0.01) were shorter compared to the femoral approach. Electrical parameters were similar between the two approaches. There were only two complications during jugular veinous implantations (1 pericardial effusion and 1 dislocation), compared to 16 complications using the femoral approach (1 pericardial effusion, 2 femoral artery injuries, and 13 major groin haematomas).

Conclusion
The jugular approach may represent a safe and efficient alternative to femoral implantation of the Micra leadless pacemaker.
Relationship of Body Composition With Middle Cerebral Artery Hemodynamic Using Compositional Data Analysis in Middle-Age Adults From Toledo Study for Healthy Aging
Authors: Muñoz-Muñoz Miguel , Bond Bert , Sánchez-Martín Coral , Rodríguez-Gómez Irene , Weston Max , García-Aguirre Mikel , Morín-Martín María M , Alegre Luis M , Leal-Martín Javier , Alcazar Julian , Ara Ignacio , García-García Francisco José 
Published: July 2024

Abstract
Excess adipose tissue may promote chronic systemic inflammation and oxidative stress, causing endothelial damage. Early evidence indicates that obesity may be associated with poorer cerebral perfusion. The purpose of this study was to examine the relationship between body composition and cerebral hemodynamics. A total of 248 middle-aged adults (50–58 years old; 55% women) underwent a ramp test on a cycle-ergometer until volitional exhaustion. Gas exchange was assessed on a breath-by-breath basis. Mean middle cerebral artery velocity (MCAv) was measured using transcranial Doppler, and pulsatility index (PI) was calculated. Body composition was assessed by dual X-ray absorptiometry. Statistical analyses were performed using a compositional data approach including a 3-compartment model for body composition (trunk fat mass, extremities fat mass, and fat-free mass). The unadjusted models for the whole sample showed that trunk fat mass relative to other compartments was negatively associated with MCAvrest, MCAvmax, and gain, and positively associated with PImax; extremities fat mass relative to other compartments was positively associated with MCAvrest and MCAvmax, and negatively associated with PImax; and fat-free mass relative to other compartments was positively associated with PImax. These associations were sex-dependent, remaining in the women’s subgroup. However, after adjusting for confounders, these associations became nonsignificant, except for PImax in the whole sample and women’s subgroup. These findings suggest a possible association between cerebral hemodynamics and body composition in middle-aged adults, highlighting sex-specific differences. Moreover, our results indicate that higher trunk fat mass relative to other compartments may negatively affect cerebral hemodynamics, reducing MCAv and increasing PImax.
Transient electromagnetic inversion to image the shallow subsurface based on convolutional bidirectional long short-term memory neural networks
Authors: Shi Yu , Zhang Jifeng , You Xiran , Ma Ziben , Li Jiachen 
Published: July 2024

SUMMARY
The conventional transient electromagnetic inversion method has a low calculation speed and precision and is susceptible to falling into local minima, which does not meet the fine detection requirements of urban underground space. In this study, we proposed a novel inversion method based on convolutional bidirectional long short-term memory neural networks for shallow subsurface transient electromagnetic inversion. This network structure possessed strong spatial feature extraction capabilities and a proficient understanding of sequential data, thereby addressing the issues of slow conventional inversion computations and inadequate inversion accuracy. Utilizing the apparent resistivity from a three-layer model as the sample input and the real model as the target, the network was trained using batch normalization and dropout techniques to accelerate the convergence rate. The resulting model achieved real-time inversion speeds and high accuracy, with robust generalization capabilities and adaptability to new data. To assess the inversion performance, we used a novel 1-D inversion error calculation index, the correlation area loss error, for a more accurate measurement. Numerical simulation experiments showed that the proposed method required only 2.121 s to invert data from 100 observation points. The inversion efficiency was significantly superior to the conventional methods, maintaining excellent accuracy while effectively discerning subsurface electrical stratification in geophysics. Applying convolutional bidirectional long short-term memory neural networks to multidimensional and field data yielded results superior to those of conventional inversion, demonstrating the promising applicability and generalization of this approach. This study offers an efficient solution for shallow subsurface transient electromagnetic exploration and holds potential for application in other areas.
The Human Glycome Atlas project for cataloging all glycan-related omics data in human
Authors: Aoki-Kinoshita Kiyoko F , Akune-Taylor Yukie , Ando Hiromune , Angata Kiyohiko , Fujita Morihisa , Furukawa Jun-ichi , Kaji Hiroyuki , Kato Koichi , Kitajima Ken , Kizuka Yasuhiko , Matsui Yusuke , Nakajima Kazuki , Nishihara Shoko , Okajima Tetsuya , Sakamoto Kazuma , Sato Chihiro , Thaysen-Andersen Morten , Togayachi Akira , Yagi Hirokazu , Zappa Achille , Kadomatsu Kenji 
Published: July 2024

Abstract
The Human Glycome Atlas (HGA) Project was launched in April 2023, spearheaded by three Japanese institutes: the Tokai National Higher Education and Research System, the National Institutes of Natural Sciences, and Soka University. This was the first time that a field in the life sciences was adopted by the Ministry of Education, Culture, Sports, Science and Technology (MEXT) for a Large-scale Academic Frontiers Promotion Project. This project aims to construct a knowledgebase of human glycans and glycoproteins as a standard for the human glycome. A high-throughput pipeline for comprehensively analyzing 20,000 blood samples in its first five years is planned, at which time an access-controlled version of a human glycomics knowledgebase, called TOHSA, will be released. By the end of the final tenth year, TOHSA will provide a central resource linking human glycan data with other omics data including disease-related information.
An expert opinion on rescuing atypically pronucleated human zygotes by molecular genetic fertilization checks in IVF
Authors: Capalbo Antonio , Cimadomo Danilo , Coticchio Giovanni , Ottolini Christian Simon 
Published: July 2024

Abstract
IVF laboratories routinely adopt morphological pronuclear assessment at the zygote stage to identify abnormally fertilized embryos deemed unsuitable for clinical use. In essence, this is a pseudo-genetic test for ploidy motivated by the notion that biparental diploidy is required for normal human life and abnormal ploidy will lead to either failed implantation, miscarriage, or significant pregnancy complications, including molar pregnancy and chorionic carcinoma. Here, we review the literature associated with ploidy assessment of human embryos derived from zygotes displaying a pronuclear configuration other than the canonical two, and the related pregnancy outcome following transfer. We highlight that pronuclear assessment, although associated with aberrant ploidy outcomes, has a low specificity in the prediction of abnormal ploidy status in the developing embryo, while embryos deemed abnormally fertilized can yield healthy pregnancies. Therefore, this universal strategy of pronuclear assessment invariably leads to incorrect classification of over 50% of blastocysts derived from atypically pronucleated zygotes, and the systematic disposal of potentially viable embryos in IVF. To overcome this limitation of current practice, we discuss the new preimplantation genetic testing technologies that enable accurate identification of the ploidy status of preimplantation embryos and suggest a progress from morphology-based checks to molecular fertilization check as the new gold standard. This alternative molecular fertilization checking represents a possible non-incremental and controversy-free improvement to live birth rates in IVF as it adds to the pool of viable embryos available for transfer. This is especially important for the purposes of ‘family building’ or for poor-prognosis IVF patients where embryo numbers are often limited.