bluuebunny/crossref_metadata_2025_split huggingface dataset:
Towards a net‐zero future for refineries: A case study on capacity configuration for hydrogenation demands in a refinery
Authors: He Wangli , Chen Lijia , Qing Xiangyun , Qian Feng 
Published: February 2025

AbstractThe refining industry's substantial hydrogen demand relies on high‐carbon‐emission production methods, facing dual challenges of reducing costs and achieving net‐zero emissions. This study proposes a renewable energy‐powered water electrolysis system integrated with seasonal hydrogen storage to address these challenges. A multi‐objective capacity optimization model is developed to minimize costs and carbon emissions, ensuring reliable hydrogen supply. To manage computational complexity, time variational autoencoder is applied to extract patterns from high‐dimensional data for scenario generation and typical day selection. A refinery case study validates the system's capacity configuration. Pareto analysis reveals a tradeoff between costs and emissions, necessitating large‐scale seasonal hydrogen storage to balance renewable energy fluctuations, while battery storage manages short‐term fluctuations. Sensitivity analysis shows exceeding a 0.38 electrolyzer minimum load reduces the economic viability of renewable hydrogen production. The system achieves an LCOH of 2.28 USD/kg and annual carbon emissions of 361,139 tons, offering cost‐effective and sustainable hydrogen production.
Scaling Laws for Discriminative Classification in Large Language Models
Authors: Wyatte Dean , Tahmasbi Fatemeh , Li Ming , Markovich Thomas 
Published: February 2025

ABSTRACTModern large language models (LLMs) represent a paradigm shift in what can plausibly be expected of machine learning models. The fact that LLMs can effectively generate sensible answers to a diverse range of queries suggests that they would be useful in customer support applications. While powerful, LLMs have been observed to be prone to hallucination which unfortunately makes their near‐term use in customer support applications challenging. To address this issue, we present a system that allows us to use an LLM to augment our customer support advocates by re‐framing the language modeling task as a discriminative classification task. In this framing, we seek to present the Top‐K best template responses for a customer support advocate to use when responding to a customer. We present the result of both offline and online experiments where we observed offline gains and statistically significant online lifts for our experimental system. Along the way, we present observed scaling curves for validation loss and Top‐K accuracy, resulted from model parameter ablation studies. We close by discussing the space of trade‐offs with respect to model size, latency, and accuracy as well as and suggesting future applications to explore.
Experiences of women farmworkers in Michigan: Perspectives from the Michigan Farmworker Project
Authors: Handal Alexis J. , Iglesias‐Rios Lisbeth , Valentín‐Cortés Mislael A. , O'Neill Marie S. 
Published: February 2025

AbstractAgricultural work presents significant physical and social challenges globally and in the United States, with women farmworkers facing unique risks that remain underexplored. This study examines the social and occupational hazards confronted by women farmworkers in Michigan using data from the Michigan Farmworker Project. In‐depth interviews with farmworkers were thematically analyzed. Results highlight five main dimensions of working and living conditions: gender‐based discrimination, sexual harassment, reproductive health concerns, pregnancy challenges, and work‐life balance issues. Women and men participants (n = 35; average age of 42 years; 57% women) reported hazardous and exploitative conditions including sexual harassment, chemical exposures, and challenges with proper hygiene and sanitation—especially during menstruation—including lack of bathroom access and other problems leading to urinary tract infections. Participants discussed pregnancy‐specific concerns and concerns regarding work‐life balance and childcare (i.e., insufficient time for family, challenges with coordination of childcare). Findings underscore the need for policies to address these disparities, especially for single women farmworkers. Interventions and policies informed by this study can improve the well‐being of women workers and their families in agricultural settings.
Viviendo con dignidad: Lived experiences of Latina immigrant survivors of intimate partner violence with housing in the US
Authors: López‐Zerón Gabriela , Guerrero Mayra , Molina Dilcia , Moncada Leslie , Hurtado Gabriela , Chaplin Marisela , Terrones Michelle , Paz Rafael , Caballero Ashley 
Published: February 2025

AbstractIntimate partner violence (IPV) increases the risk of homelessness and housing instability, particularly among Latine immigrant survivors in the USA. Latina immigrant women face disproportionate impacts of IPV and heightened risks for homelessness and housing instability, yet remain underrepresented in the IPV and housing literature, where methodologies regularly fail to center their voices and lived experiences. This study addresses this gap by utilizing Participatory Action Research (PAR) to investigate the housing experiences of Latina immigrant survivors (N = 14) through in‐depth interviews conducted in Spanish. Study findings reveal multifaceted housing experiences and challenges, including unsanitary and unsafe living conditions, landlord abuse, as well as discrimination and language barriers. The concept of dignidad (dignity) was central to survivors' narratives, which survivors identified as integral to safe and stable housing. Recommendations highlight the need for holistic, culturally‐grounded housing services in survivors' preferred language. By highlighting Latina immigrant survivors' lived experiences and definitions of safe and stable housing, and punctuating the importance of language justice, this study underscores the need for tailored interventions that address the unique needs and challenges of this population. Additionally, survivors' recommendations offer actionable insights for policy makers and practitioners seeking to improve housing services for Latina immigrant survivors.
Growth and Growth‐Promoting Treatments in Turner Syndrome
Authors: Kanakatti Shankar Roopa , Quigley Charmian A. , Isojima Tsuyoshi , Mauras Nelly , Chernausek Steven D. , Wasniewska Malgorzata , Sas Theo C. J. 
Published: February 2025

ABSTRACTShort stature is a common presenting feature and an important concern for families of children with Turner syndrome. In this review, we summarize the data that shaped the updated international consensus guidelines for Turner syndrome published in 2024. The natural history of growth in Turner syndrome, the safety and efficacy of recombinant human growth hormone therapy, and the alternate growth promoting agents under consideration are presented. Timely, adequate growth hormone therapy can counter growth failure in childhood, promote catch‐up growth and help many individuals with Turner syndrome attain a near‐normal adult height. However, individual responses to growth hormone treatment are highly variable and are influenced by factors such as parental heights, age, baseline height, timing of estrogen initiation and pubertal status. Shared decision making on initiation of treatment, a candid conversation regarding the modest gradual height gain resulting from growth hormone therapy, and individualization of therapeutic goals can facilitate realistic expectations of growth promoting therapy in Turner syndrome.
Prevalence of idiopathic normal pressure hydrocephalus in older adult population in Shanghai, China: A population‐based observational study
Authors: Fang Xuhao , Xu Xinxin , Liu Chunyan , Li Shihong , Deng Yao , Tang Feng , Zhang Li , Xing Yan , Mao Renling , Hu Jin 
Published: February 2025

AbstractINTRODUCTIONIdiopathic normal pressure hydrocephalus (iNPH), a condition that primarily affects the elderly, has an unclear prevalence rate in China.METHODSA cross‐sectional survey involving 1491 seniors aged 60 and above in Shanghai was conducted. Clinical symptoms and brain imaging data were collected for the diagnosis of suboptimal probable iNPH (s‐probable iNPH). The crude prevalence was calculated and the estimated prevalence was inferred.RESULTSThe crude prevalence of s‐probable iNPH was 3.09% and 2.62% respectively, using DESH score ≥6 and Radscale score ≥7 as the primary imaging diagnostic criteria. The estimated prevalence of Shanghai was 2.59% among people over 60 years old and it rose to 7.99% among people aged over 90, and it was estimated that 134,152 and 11,708, respectively, had s‐probable iNPH among the corresponding age group.DISCUSSIONThe prevalence of s‐probable iNPH fluctuates based on the radiological scoring systems and the defined thresholds employed, and it tends to rise with advancing age.Highlights
**Significant Prevalence**: The study identified a substantial prevalence of iNPH in older adults, with rates increasing significantly with age, particularly among those aged 90–99 years and centenarians.
**Diagnostic Approach**: The research utilized novel diagnostic methodologies by integrating the DESH score or Radscale score with stringent clinical symptoms, providing a closer approximation to the true prevalence of iNPH.
**Gender Disparity**: A marked gender difference was observed, with the prevalence of iNPH being significantly higher in males compared to females across all age groups.
**Clinical Implications**: The findings underscore the importance of considering iNPH in the differential diagnosis of dementia, particularly among older male patients presenting with cognitive impairment and gait disturbances.
**Public Health Impact**: The estimated number of s‐probable iNPH patients in Shanghai highlights the need for increased awareness and better management strategies for this underdiagnosed condition in the aging population.
Mapping Molecular Pathways of Multiple Sclerosis: A Gene Prioritization and Network Analysis of White Matter Pathology Transcriptomics
Authors: Abbadessa Gianmarco , Nagano Ai , Hametner Simon , Howell Owain , Owen David , Papadaki Artemis , Srivastava Prashant , Bonavita Simona , Magliozzi Roberta , Reynolds Richard , Rizig Mie , Nicholas Richard 
Published: February 2025

ObjectivesRapid advances in transcriptomics have driven efforts to identify deregulated pathways in multiple sclerosis (MS) tissues, though many detected differentially expressed genes are likely false positives, with only a small fraction reflecting actual pathological events. Robust, integrative methods are essential for accurately understanding the molecular mechanisms underlying MS pathology.MethodsWe conducted a gene prioritization analysis of MS white matter pathology transcriptomic studies. Articles were sought in Scopus and PubMed up to July 31, 2024. Potentially eligible publications were those that provided either transcriptomics datasets (deposited in GEO) or lists of differentially expressed genes comparing MS white matter to control white matter.ResultsApplying a vote‐count strategy to search for the intersection of genes reported in multiple independent studies with a consistent fold‐change direction, followed by a Monte Carlo simulation, we identified 528 highly significant differentially expressed multi‐study genes (p < 0.0001; 10,000 simulations). Functional enrichment analysis revealed deregulation of the folate pathway in MS normal‐appearing white matter, and tumor necrosis factor (TNF) ‐related and complement‐related pathways in active and chronic active lesions, respectively. Network analysis identified 6 key signaling hubs: PTPRC, HLA‐B, MYC, MMP2, COL11A2, MAG. The major nodes identified revealed mechanistic concordance with published in vivo MS models, supporting their value as potential therapeutic targets.InterpretationOur strategy provides a robust framework for integrating gene expression data, effectively identifying the intricate pathways altered in human diseased tissues. This method holds potential for translating findings into drug development strategies. ANN NEUROL 2025
Improvement in the Electro‐Optical Properties of Twisted Nematic Liquid Crystal Devices Through Polymeric Nanoparticles
Authors: Lin Yan‐Ting , Kuo Chung‐Yu , Huang Tzu‐Ting , Liu Chun‐Yen 
Published: February 2025

ABSTRACTThe use of metal and inorganic particles to enhance the electro‐optical properties of liquid crystal displays is well established. However, the application of polymer particles for this purpose remains relatively underexplored. To improve the electro‐optical properties of twisted nematic liquid crystal (TNLC) devices, we synthesized and acquired nanosized polydopamine (PDA), cellulose, and cyclodextrin particles. To enhance their interaction with liquid crystals, these polymeric particles were modified with dimethyloctadecyl‐3‐(trimethoxysilyl)propyl ammonium chloride (DMOAP), resulting in radial constructions. A β‐cyclodextrin (β‐CD) inclusion complex with 4‐cyano‐4′‐pentylbiphenyl was also synthesized for further study. The TNLC cells doped with synthesized PDA particles presented a contrast ratio of 39.3, a low threshold voltage of 4.5 V, and a fast average response time of 18 ms. Furthermore, the TNLC cells doped with the β‐CD inclusion complex particles presented the highest contrast ratio of 49.4, an even lower threshold voltage of 4.4 V, and the fastest average response time of 6.8 ms, indicating superior electro‐optical performance. This approach offers a novel method for developing high‐performance, low‐cost, and easily processed liquid crystal display devices.
Equity in Early Life: Advancing Environmental Justice for Maternal and Child Health
Authors: Ceri Ayhan , Keskin Dogukan 
Published: February 2025

ABSTRACTBackgroundEnvironmental justice (EJ) is essential for addressing the disproportionate burden of environmental hazards on vulnerable populations, particularly pregnant individuals and young children. Developmental sensitivity to toxic exposures, such as air pollution, lead, and endocrine‐disrupting chemicals, is compounded by systemic inequities like food insecurity and housing instability. Structural racism and socioeconomic disadvantage further exacerbate these risks, leading to higher rates of preterm birth, low birth weight, and maternal morbidity in marginalized communities.AimsThis study explores the intersection of environmental and social determinants of health, emphasizing EJ’s role in reducing disparities through community engagement, research, and policy reforms.MethodsA narrative review of policies, interventions, and case studies was conducted to assess effective EJ strategies in mitigating maternal and child health disparities.ResultsSuccessful community‐driven initiatives, such as lead abatement programs and air quality improvements, demonstrate that aligning policies with community‐identified priorities leads to measurable health benefits.DiscussionEJ‐based interventions reduce environmental risks and health inequities through participatory research and systemic policy changes. However, challenges such as limited funding and data gaps require coordinated action.ConclusionTo promote maternal and child health equity, we recommend expanding funding, institutionalizing community engagement, and leveraging innovative data collection. By prioritizing community‐led solutions, EJ can drive systemic transformation, ensuring better health outcomes for future generations.
Functional Evaluation of Neural Tube Defect‐Related Missense Mutations Using In Silico Methods
Authors: Biterge Sut Burcu 
Published: February 2025

ABSTRACTBackgroundNeural tube formation is one of the most important developmental events as it gives rise to the key organs comprising the central nervous system. Failure in the proper closure of the neural tube results in congenital abnormalities, namely neural tube defects (NTDs). Previous studies have identified several single nucleotide variations that are considered risk factors and established a genetic background for the increased incidence of NTDs and factors. This study aims to provide a comprehensive functional analysis of NTD‐related missense mutations in terms of their potential effects on pathogenicity, protein stability, and structure using predictive in silico analysis tools.MethodsSingle nucleotide variations associated with NTD risk were identified by a systematic review of previous studies on Pubmed and ClinVar. Protein stability and pathogenicity scores were predicted using MUpro and PloyPhen2, respectively. Structural alterations were determined via the HOPE server. Predicted expression profiles in the brain were retrieved from the Human Protein Atlas.ResultsOur analysis identified 43 NTD‐related missense mutations in MTHFR, MTRR, PARD3, PACS1, MED12, VANGL1, VANGL2, FZD6, CELSR1, FUZ, DVL2, and LRP6 genes. We found that all of these genes are predicted to be expressed in different regions of the brain. We showed that single nucleotide variations resulted in decreased protein stability, and the majority of them were found to be damaging. We also report that the amino acid changes introduced by these mutations caused differences in size, charge, and hydrophobicity, which potentially resulted in structural alterations within the protein and affected their contacts with other proteins and ligands.ConclusionsIn conclusion, this study provides a comprehensive analysis of NTD‐related missense mutations regarding their potential damaging effects, which might contribute to the pathogenesis of NTDs.
Detektion innerer Spannstahlbrüche durch faseroptische Messungen an Betonoberflächen
Authors: Paul Aeneas , Sanio David , Mark Peter 
Published: February 2025

AbstractUnerkannte innere Spannstahlbrüche stellen ein Risiko für Spannbetontragwerke dar. Sofern eine Vorankündigung durch Rissbildung rechnerisch nicht nachgewiesen werden kann, sind Abbruch und Neubau oft die Konsequenz. In diesem Beitrag wird eine experimentelle Methode zur Erkennung und Lokalisierung solcher Schäden mittels faseroptischer Messtechnik vorgestellt. Infolge des Vorspannungsverlusts sowie der Neuverankerung des Spannglieds im umgebenden Beton entstehen charakteristische Änderungen im Dehnungsfeld an der Betonoberfläche. Diese werden mit einem zweidimensionalen Gitter aus faseroptischen Sensoren detektiert. In experimentellen Untersuchungen an Spannbetonträgern wurden Spannstahlbrüche erzeugt und die daraus resultierenden Dehnungsfelder an der Oberfläche gemessen. Die Neuverankerung im Beton wurde mithilfe von Sensoren an den Spanngliedern bewertet. Relevante Einflussgrößen auf das Messsignal wurden durch Variation der Betonfestigkeitsklasse, der Tiefenlage der Spannglieder sowie der Vordehnung des Spannstahls untersucht. Zusätzlich wurde der Einfluss von Biegerissen auf das Messsignal bewertet. Es zeigt sich, dass Spanngliedbrüche bis in Tiefen von 25 cm von der Oberfläche klar erkannt und lokalisiert werden können. Als Messgröße sind die Dehnungsänderungen entlang der Spanngliedachse besonders geeignet. Die Dehnungsänderungen orthogonal zum Spannglied zeigen schwächer, aber ebenfalls die Bruchstelle an und bilden eine sinnvolle Ergänzung des Messsystems.
Phytochemical characterization and potential anti‐oxidative activity of Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso and cv Super essential oils compared to a commercial lavender essential oil
Authors: Mac Sweeney Eileen , Pieracci Ylenia , Popescu Vlad Sebastian , Angius Gianluca , Flamini Guido , Pistelli Luisa , Abate Giulia , Mastinu Andrea 
Published: February 2025

This study investigates the phytochemical profiles and antioxidant properties of three lavender essential oils (LEOs) from Lavandula angustifolia subsp. pyrenaica (DC.), Lavandula x intermedia Emeric ex Loisel cv Grosso, Lavandula x intermedia Emeric ex Loisel cv Super, and compares them to a commercial one. LEOs were extracted by hydrodistillation, analyzed using gas chromatography‐mass spectrometry (GC‐MS), and tested for antioxidant effects on human SH‐SY5Y neuroblastoma cells. The major components identified in all the four LEOs were linalool and linalyl acetate; however, in the commercial LEO differences in minor compounds and the presence of additives were found. Antioxidant activity assays revealed significant protection against H₂O₂‐induced oxidative stress for hydrodistilled EOs, while the commercial EO showed no protective effect. Gene expression analysis indicated upregulation of antioxidant‐related genes in cells treated with “Grosso” and “Super” LEOs. This research highlights the potential therapeutic applications of lavender EOs, with a particular emphasis on the differences between naturally derived oils and commercial variants.
“Better Late Than Never”—Late‐Onset Genotype‐Negative Congenital Long QT Syndrome: Case Report and Review
Authors: Tan Clement , Thanabalasingam Vaikunthan , Sella Kapu Chaminda , Zhang Zhihua 
Published: February 2025

ABSTRACTCongenital long QT syndrome (LQTS) is a genetic disorder causing prolonged QT intervals and an increased risk of arrhythmias and sudden cardiac death. With 25% of cases lacking known genetic mutations, diagnosis and treatment can be challenging. We present a successfully managed case of late‐onset genotype‐negative phenotype‐positive LQTS presenting as palpitations, complicated by a single event of polymorphic ventricular tachycardia, followed by a review of the literature. This case underscores the gaps in understanding congenital long QT syndrome, especially in genotype‐negative cases, and highlights the need for ongoing research for risk assessment and effective management to prevent fatal cardiac events.
Stepping into the role of Editor‐in‐Chief of the Journal of Cell Communication and Signaling
Authors: Chaqour Brahim 
Published: February 2025

AbstractI am deeply honored to have been appointed as the new Editor‐in‐Chief (EiC) of the Journal of Cell Communication and Signaling (JCCS). As I step into this role of EiC, I look forward to continuing collaborating with the dedicated readership, expert reviewers, editorial board members, and the publisher of the journal to advancing knowledge in research on cell communication and signaling governing key biochemical and physiological processes both in normal and pathological conditions. JCCS remains dedicated to publishing cutting‐edge research, while continuously expanding the range of submissions and refining the review and editorial processes to ensure a more inclusive and impactful scientific contribution. I would like to thank the founder of JCCS and my predecessor EiC, Prof. Bernard Perbal and his right hand Annick Perbal for their enormous contribution to JCCS, and their crucial role shaping the Journal into a platform that welcomes innovative research and enhances our understanding of cellular communication networks in health and diseases and for steering us safely over the last two decades through the increasingly challenging scientific publication landscape. In this editorial, I share some of my reflections, ideas, acknowledgments, and aspirations for the future of the journal.