bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Introducing Deep Eutectic Solvents as Biorenewable Media for Au(I)‐Catalyzed Cycloisomerization of γ‐Alkynoic Acids: An Unprecedented Catalytic System.
Authors: Rodriguez‐Alvarez Maria J. , Vidal Cristian , Diez Josefina , Garcia‐Alvarez Joaquin 
Published: March 2015

AbstractThe cycloisomerization of γ‐alkynoic acids into cyclic enol‐lactones proceeds under mild and aerobic conditions and, for the first time, in a deep eutectic solvent (choline chloride/urea).
ChemInform Abstract: Synthesis of 2‐Vinylbenzofurans via the Copper‐Catalyzed Multicomponent Reactions Involving an Oxa‐Michael/Arylation/Vinylation Cascade.
Authors: Wan Jie‐Ping , Wang Hang , Liu Yunyun , Ding Hanfeng 
Published: March 2015

AbstractTitle compounds (V) are prepared via the multicomponent reaction of o‐iodophenols (I), in situ generated allenes, and dichloromethane (IV).
ChemInform Abstract: Metal‐Free n‐Et4NBr‐Catalyzed Radical Cyclization of Disulfides and Alkynes Leading to Benzothiophenes under Mild Conditions.
Authors: Yang Daoshan , Yan Kelu , Wei Wei , Tian Laijin , Li Qinghe , You Jinmao , Wang Hua 
Published: March 2015

AbstractThe green and efficient method succeeds with almost identical yields using diethyl instead of dimethyl acetylenedicarboxylate as the C1‐source, but fails with terminal alkynes and 1,2‐dialkyl or 1,2‐diarylalkynes.
ChemInform Abstract: Tandem One‐Pot Synthesis of Polysubstituted NH‐Pyrroles Involving the Palladium‐Catalyzed Intramolecular Oxidative Amination of the Zinc Bromide Complex of β‐Enamino Esters.
Authors: Kim Ju Hyun , Choi Suh Young , Bouffard Jean , Lee Sang‐gi 
Published: March 2015

AbstractThe sequence proceeds via Zn complexes of type (IV) and affords the target compounds in a regioselective manner.
ChemInform Abstract: Synthesis of N‐(2,3,4,5,6‐Pentafluorobenzyloxy)‐γ‐lactams by Rhodium‐Catalyzed Cyclization of Diazo Amides.
Authors: Budny Marcin , Nowak Magdalena , Wojtczak Andrzej , Wolan Andrzej 
Published: March 2015

AbstractA series of diazo amides bearing the ‐Fbo protecting group is successfully cyclized to γ‐lactam structures with different yields and stereoselectivities.
ChemInform Abstract: 1,4‐Diazabicyclo[2.2.2]octane‐Mediated Ring Opening of 1‐Acetylcyclopropanecarboxamides and Its Application to the Construction of 3‐Alkylated γ‐Lactams.
Authors: Li Ling , Wei Enxiang , Lin Shaoxia , Liu Bing , Liang Fushun 
Published: March 2015

AbstractThe reaction proceeds with the formation of the DABCO‐containing zwitter ions [cf.
ChemInform Abstract: Phosphine‐Catalyzed [4 + 1] Annulation of 1,3‐(Aza)dienes with Maleimides: Highly Efficient Construction of Azaspiro[4.4]nonenes.
Authors: Yang Mei , Wang Tianyi , Cao Shixuan , He Zhengjie 
Published: March 2015

AbstractCompounds (VII) are isolated as diastereomeric mixtures due to hindered rotation of the aryl groups caused by steric hindrance of the ortho‐substituents.
ChemInform Abstract: Multicomponent Decarboxylative Allylations.
Authors: Ariyarathna Yamuna , Tunge Jon A. 
Published: March 2015

AbstractThe reaction of Meldrum′s acid derivatives (II), pyrrolide (I) and allyl carbonates (III) allows a multicomponent decarboxylative coupling to form allylated acyl pyrroles (IV).
ChemInform Abstract: Preparation of 3‐Diazoindolin‐2‐imines via Cascade Reaction Between Indoles and Sulfonylazides and Their Extensions to 2,3‐Diaminoindoles and Imidazo[4,5‐b]indoles.
Authors: Sheng Guorong , Huang Kai , Chi Zhihao , Ding Hualong , Xing Yanpeng , Lu Ping , Wang Yanguang 
Published: March 2015

Abstract3‐Diazoindolin‐2‐imines (III) and (X) are prepared from indoles (I) and sulfonylazides via an electronically matched 1,3‐dipolar cycloaddition/dehydroaromatization/ring‐opening cascade.
ChemInform Abstract: Palladium‐Catalyzed Difunctionalization of Alkynes via C—N and S—N Cleavages: A Versatile Approach to Highly Functional Indoles.
Authors: Zhao Fei , Zhang Dengyou , Nian Yong , Zhang Lei , Yang Wei , Liu Hong 
Published: March 2015

AbstractThis Pd‐catalyzed intramolecular aminoacylation of N‐substituted tertiary 2‐alkynylanilines proceeds via migration of the N‐substituent to C‐3 of the formed indole derivative while the reaction of secondary anilines (XIII) gives the corresponding N‐substituted indoles (XIV) only.
ChemInform Abstract: One‐Pot Approach to 1,2‐Disubstituted Indoles via Cu(II)‐Catalyzed Coupling/Cyclization under Aerobic Conditions and Its Application for the Synthesis of Polycyclic Indoles.
Authors: Gao Jilong , Shao Yingying , Zhu Jiaoyan , Zhu Jiaqi , Mao Hui , Wang Xiaoxia , Lv Xin 
Published: March 2015

AbstractThe title process is applied to the preparation of a variety of target compounds.
ChemInform Abstract: Metal‐Free Syntheses of Oxindole Derivatives via a Benzoylation/Substitution/Desulfonylation/Cyclization Cascade.
Authors: Niu Ben , Xie Ping , Zhao Wannian , Zhou Yang , Bian Zhaogang , Pittman Charles U. Jr. , Zhou Aihua 
Published: March 2015

AbstractThe novel metal‐free cascade reaction starts from aldehydes and methacrylamides and it enriches current methods of generating oxindole derivatives.
ChemInform Abstract: Rhodium(III)‐Catalyzed Intramolecular Redox‐Neutral Annulation of Tethered Alkynes: Formal Total Synthesis of (.+‐.)‐Goniomitine.
Authors: Zhou Bing , Du Juanjuan , Yang Yaxi , Li Yuanchao 
Published: March 2015

AbstractThe cyclization procedure affords indole structures bearing a C‐2 alkyl side chain with terminal amide function.
ChemInform Abstract: A Base‐Mediated Mild Sulfenylation of Indoles and Pyrrole with α‐Acylthiones.
Authors: Viglianisi Caterina , Marcantoni Enrico , Carapacchi Vanessa , Menichetti Stefano , Marsili Laura 
Published: March 2015

AbstractIndole derivatives react with 1 equiv.
ChemInform Abstract: Shortcut Approach to Cyclopenta[b]indoles by [3 + 2] Cyclodimerization of Indole‐Derived Cyclopropanes.
Authors: Ivanova Olga A. , Budynina Ekaterina M. , Skvortsov Dmitriy A. , Trushkov Igor V. , Melnikov Mikhail Ya. 
Published: March 2015

AbstractThe products show moderate cytotoxicity in vitro.
ChemInform Abstract: An Intermolecular C—H Functionalization Method for the Synthesis of 3‐Hydroxy‐2‐oxindoles.
Authors: Chen Jinsen , Song Chao , Chen Pei , Zhu Jin 
Published: March 2015

AbstractThe reductive denitrosation‐triggered cyclization of substrates (I) leads readily to desired 3‐hydroxy‐2‐oxindoles.
ChemInform Abstract: An Efficient Route to Synthesize Isatins by Metal‐Free, Iodine‐Catalyzed Sequential C(sp3)—H Oxidation and Intramolecular C—N Bond Formation of 2′‐Aminoacetophenones.
Authors: Rajeshkumar Venkatachalam , Chandrasekar Selvaraj , Sekar Govindasamy 
Published: March 2015

AbstractA series of isatins (II) is prepared by iodine‐catalyzed oxidation—cyclization of o‐aminoacetophenones (I) with DMSO as both a reagent and a solvent.
ChemInform Abstract: Palladium(0)‐Catalyzed Heck Reaction/C—H Activation/Amination Sequence with Diaziridinone: A Facile Approach to Indolines.
Authors: Zheng Huaiji , Zhu Yingguang , Shi Yian 
Published: March 2015

AbstractA novel cascade reaction involving a Heck reaction/C—H activation/amination sequence with iodobenzenes (I), olefins such as (II), and di‐tert‐butyldiaziridine (III) providing access to a variety of polycyclic indolines, e.g. (IV), is reported.
ChemInform Abstract: A Cation‐Directed Two‐Component Cascade Approach to Enantioenriched Pyrroloindolines.
Authors: Wolstenhulme Jamie R. , Cavell Alex , Gredicak Matija , Driver Russell W. , Smith Martin D. 
Published: March 2015

AbstractUsing TBAB as the cationic catalyst and aryl isocyanides (II) gives pyrroloindolines (III) with good diastereoselectivity while alkyl isocyanides (V) give 1:1 mixtures of diastereomers (VI).
ChemInform Abstract: Copper‐Catalyzed One‐Pot Synthesis of N‐Aryl Oxazolidinones from Amino Alcohol Carbamates.
Authors: Mahy William , Plucinski Pawel K. , Frost Christopher G. 
Published: March 2015

AbstractThe synthetic utility of this cyclization is demonstrated in the synthesis of the reversible MAO‐A inhibitor Toloxatone (XII).
ChemInform Abstract: Electrochemical Intramolecular Aminooxygenation of Unactivated Alkenes.
Authors: Xu Fan , Zhu Lin , Zhu Shaobin , Yan Xiaomei , Xu Hai‐Chao 
Published: March 2015

AbstractAddition of a nitrogen‐centered radical to alkenes generates a cyclized radical intermediate which is trapped by TEMPO (II).
ChemInform Abstract: Synthesis of 5‐(Fluoromethyl)‐4,5‐dihydroisoxazoles by Silver‐ Catalyzed Oxyfluorination of Unactivated Alkenes.
Authors: Liu Yan‐Yun , Yang Ji , Song Ren‐Jie , Li Jin‐Heng 
Published: March 2015

AbstractThe title synthesis features a new 1,2‐difunctionalization of unactivated alkenes using commercially available Selectfluor via a radical pathway.
ChemInform Abstract: Carbon Dioxide as a Primary Oxidant and a C1 Building Block.
Authors: Bors Istvan , Kaizer Jozsef , Speier Gabor , Giorgi Michel 
Published: March 2015

Abstract3H‐Phenanthro[9,10‐d]oxazol‐2‐ones (III) are prepared either from 9,10‐phenanthrenequinone monoimines (I) in the presence of PPh3 or 2,3‐dihydro‐2,2,2‐triphenylphenanthro [9,10‐d]‐1,3,2‐λ5‐oxazaphospholes (IV) using CO2 as C1 building block.
ChemInform Abstract: Oxime‐Mediated Facile Access to 5‐Methylisoxazoles and Applications in the Synthesis of Valdecoxib and Oxacillin.
Authors: Dong Kui‐Yong , Qin Hai‐Tao , Bao Xing‐Xing , Liu Feng , Zhu Chen 
Published: March 2015

AbstractThe title reaction affords a variety of 5‐methylisoxazoles in moderate to good yields.
ChemInform Abstract: Heterogeneous Copper‐Catalyzed Cascade Three‐Component Reaction of Amines, Carbon Disulfide and 2‐Iodoanilines Leading to 2‐Aminobenzothiazoles.
Authors: Zhao Hong , He Wen , Yao Ruiya , Cai Mingzhong 
Published: March 2015

Abstract2‐Aminobenzothiazoles are prepared from secondary amines, carbon disulfide, and iodoanilines in the presence of a immobilized copper catalyst in excellent yields.
ChemInform Abstract: Rhodium‐Catalyzed Enantioselective [2 + 2 + 2] Cycloaddition of Tosylamide‐Linked 5‐Allenal and 5‐Allenone with Internal Alkynes.
Authors: Sakashita Kazuki , Masutomi Koji , Noguchi Keiichi , Tanaka Ken 
Published: March 2015

AbstractThis [Rh(cod)2]BF4/(S)‐BINAP‐catalyzed cycloaddition usually proceeds with high regioselectivity.
ChemInform Abstract: Synthesis of New and Known Dicoumarols in Aqueous Media: A Green and Convenient Procedure Promoted by Titanium(IV) Oxide Nanoparticles.
Authors: Khodabakhshi Saeed , Shahamirian Mozhgan , Baghernejad Mojtaba 
Published: March 2015

AbstractA simple, green, and completely chemoselective synthesis of title compounds (III) from 4‐hydroxycoumarin (I) and various arylglyoxals (II) is accomplished.
ChemInform Abstract: Versatile Palladium‐Catalyzed C—H Olefination of (Hetero)arenes at Room Temperature.
Authors: She Zhijie , Shi Yang , Huang Yumin , Cheng Yangyang , Song Feijie , You Jingsong 
Published: March 2015

AbstractThe oxidative C—H cross coupling of arenes or hetarenes with linear or cyclic alkenes proceeds with the use of the in situ generated, highly electrophilic Pd‐species, e.g. [Pd(TFA)2].
ChemInform Abstract: Tandem Synthesis of Polysubstituted Pyridines via the Indium(III)‐Triflate‐Catalyzed Cycloaddition/Oxidative Aromatization of Blaise Reaction Intermediates with α,β‐Unsaturated Ketones.
Authors: Xuan Zi , Rathwell Kris , Lee Sang‐gi 
Published: March 2015

AbstractIn absence of oxygen in the second step, a subsequent oxidation stage is needed to achieve full aromatization of the pyridine ring.
ChemInform Abstract: Development of a Mild and Versatile Directed Cycloaddition Approach to Pyridines.
Authors: Bachollet Sylvestre P. J. T. , Vivat Jerome F. , Cocker Dean C. , Adams Harry , Harrity Joseph P. A. 
Published: March 2015

AbstractA Lewis base directed cycloaddition of triazines with alkynylboranes allows the regioselective approach to highly substituted pyridine structures including bipyridines.
ChemInform Abstract: Synthesis of Fluorescent 2,3,5,6‐Tetraalkynylpyridines by Site‐Selective Sonogashira‐Reactions of 2,3,5,6‐Tetrachloropyridines.
Authors: Ehlers Peter , Petrosyan Andranik , Neubauer Antje , Broese Timo , Lochbrunner Stefan , Ghochikyan Tariel V. , Saghyan Ashot S. , Langer Peter 
Published: March 2015

AbstractTwo series of 2,3,5,6‐tetraalkynylpyridines (V) and (VI) are prepared and their fluorescence is studied.
ChemInform Abstract: A Convenient Allenoate‐Based Synthesis of 2‐Quinolin‐2‐yl Malonates and β‐Ketoesters.
Authors: Selig Philipp , Raven William 
Published: March 2015

AbstractN‐Protected o‐aminobenzaldehydes (I) react with α,γ‐dialkylallenoates (II) to yield 2,3‐disubstituted quinolines (III).
ChemInform Abstract: Enantioselective Deprotonative Ring Contraction of N1‐Methyl‐N4‐Boc‐benzo[e][1,4]diazepine‐2,5‐diones.
Authors: Antolak Stephanie A. , Yao Zhong‐Ke , Richoux Gary M. , Slebodnick Carla , Carlier Paul R. 
Published: March 2015

AbstractUpon deprotonation, title compounds (I) undergo ring contraction to the corresponding quinolone‐2,4‐diones (II) with high enantioselectivity.
ChemInform Abstract: Cerium(IV)‐Catalyzed sp3 C—H Bond Oxidation of Glycine Derivatives: Radical Cation Prompted Dioxygen Activation in the Presence of Triarylamine.
Authors: Liu Jing , Wang Yaxin , Yu Liangliang , Huo Congde , Wang Xicun , Jia Xiaodong 
Published: March 2015

AbstractAerobic oxidation of glycine derivatives in the presence of an in situ generated triarylamine radical cation followed by reaction with styrene derivatives affords a wide variety of functionalized quinolines.
ChemInform Abstract: Synthesis of Isoquinolin‐4‐ols by Palladium‐Catalyzed Intramolecular Nucleophilic Addition of Aryl Iodides to Aldehydes.
Authors: Sole Daniel , Mariani Francesco , Fernandez Israel 
Published: March 2015

AbstractThe use of Et3N as the base is found to be essential for the Pd‐catalyzed cyclization reaction to give isoquinolin‐4‐ols.
ChemInform Abstract: Highly Stereoselective Synthesis of Functionalized Pyrrolo[3,2‐c]quinolines via N‐Heterocyclic Carbene Catalyzed Cascade Sequence.
Authors: Yang Yu‐Jie , Zhang Hai‐Rui , Zhu Shi‐Ya , Zhu Ping , Hui Xin‐Ping 
Published: March 2015

AbstractMannich—Michael‐lactamization cascade reaction of aromatic aldimines and 2‐bromoenals results in the formation of pyrroloquinolines with excellent diastereo‐ and enantioselectivities.
ChemInform Abstract: Recyclable Gold(III) Dipyridine Complex Immobilized on Fe3O4 Magnetic Nanoparticles: Synthesis of 2,6‐Dihydro[2,1‐a]isoindole under Mild Conditions.
Authors: Sadeghzadeh Seyed Mohsen 
Published: March 2015

AbstractA novel heterogenized gold(III) catalyst is synthesized and used for the synthesis of dihydroisoindoles in water.
ChemInform Abstract: Greener and Expeditious One‐Pot Synthesis of Dihydropyrimidinone Derivatives Using Non‐commercial β‐Ketoesters via the Biginelli Reaction.
Authors: Rao G. B. Dharma , Anjaneyulu B. , Kaushik M. P. 
Published: March 2015

AbstractThis new one‐pot protocol furnishes the title compounds under solvent‐ and catalyst‐free conditions with better yields and in shorter reaction times than a previously reported two‐step reaction.
ChemInform Abstract: Asymmetric Hydrogenation of 2‐Aryl‐5,6‐dihydropyrazine Derivatives with Chiral Cationic Ruthenium Diamine Catalysts.
Authors: Li Yong , He Yanmei , Chen Fei , Fan Qinghua 
Published: March 2015

AbstractThe first asymmetric hydrogenation of 2‐substituted and 2,3‐substituted 5,6‐dihydropyrazines catalyzed by a chiral cationic Ru‐diamine complex affords chiral piperazine derivatives with good enantioselectivity and good yield.
ChemInform Abstract: Enantioselective Synthesis of 3‐Substituted 1,2‐Oxazinanes via Organocatalytic Intramolecular Aza‐Michael Addition.
Authors: Cheng Shuanghua , Yu Shouyun 
Published: March 2015

AbstractA variety of 3‐substituted 1,2‐oxazinanes (II) is obtained by quinine‐catalyzed intramolecular aza‐Michael reaction of enones (I) with moderate to high enantioselectivity.
ChemInform Abstract: Synthesis of 2‐(4H‐1,2,6‐Thiadiazin‐4‐ylidene)malononitriles.
Authors: Kalogirou Andreas S. , Koutentis Panayiotis A. 
Published: March 2015

AbstractReactions of 3,5‐disubstituted 4H‐1,2,6‐thiadiazin‐4‐ones with malonodinitrile as well as other CH2‐activated reactants show surprising effects on product formation, yield and limitations.
ChemInform Abstract: Ruthenium Catalyzed Cycloisomerization of Silicon‐Tethered 1,7‐Enynes to Give Exocyclic 1,3‐Dienes.
Authors: Kaminsky Lauren , Clark Daniel A. 
Published: March 2015

AbstractThis method is also applicable for non‐silicon‐tethered substrates as demonstrated in the synthesis of (XII).
ChemInform Abstract: Iridium(III)‐Catalyzed C—H Amidation of Arylphosphoryls Leading to a P‐Stereogenic Center.
Authors: Gwon Donghyeon , Lee Donggun , Kim Jiyu , Park Sehoon , Chang Sukbok 
Published: March 2015

AbstractAn iridium(III)‐catalyst system allows the direct amidation of arylphosphoryls with various sulfonyl azides under mild conditions and for the first time in an asymmetric manner.
ChemInform Abstract: Silver‐Catalyzed Carbon—Phosphorus Functionalization of N‐(p‐Methoxyaryl)propiolamides Coupled with Dearomatization: Access to Phosphorylated Aza‐Decenones.
Authors: Wang Li‐Jing , Wang An‐Qi , Xia Yu , Wu Xin‐Xing , Liu Xue‐Yuan , Liang Yong‐Min 
Published: March 2015

AbstractThe title transformation involves phosphonation of propiolamides, 5‐exo cyclization, and dearomatization.
ChemInform Abstract: Preparation of Cyclohexenones from Acyclic (Pentadienyl)iron(1+) Cations: Synthetic Studies Directed Toward the A‐Ring of Dihydrotachysterols.
Authors: Manful Charles F. , Donaldson William A. 
Published: March 2015

AbstractThe synthesis of 3‐methyl‐4‐substituted cyclohexenones by reaction of stabilized carbon nucleophiles derived from activated methylene compounds with 3‐methylpentadienyl cation is described.
ChemInform Abstract: Development of a Concise Synthetic Approach to Access Oroxin A.
Authors: Chen Haijun , He Guihua , Li Cailong , Dong Longrong , Xie Xiaobo , Wu Jianlei , Gao Yu , Zhou Jia 
Published: March 2015

AbstractAn efficient synthetic approach to access oroxin A from inexpensive baicalin (I) is developed.
ChemInform Abstract: Coupling of Sterically Hindered Trisubstituted Olefins and Benzocyclobutenones by C—C Activation: Total Synthesis and Structural Revision of Cycloinumakiol.
Authors: Xu Tao , Dong Guangbin 
Published: March 2015

AbstractThe first total synthesis of the proposed structure of cycloinumakiol (I) and its C5 epimer (II) is presented.
ChemInform Abstract: A Highly Stable Zeotype Mesoporous Zirconium Metal—Organic Framework with Ultralarge Pores.
Authors: Feng Dawei , Wang Kecheng , Su Jie , Liu Tian‐Fu , Park Jihye , Wei Zhangwen , Bosch Mathieu , Yakovenko Andrey , Zou Xiaodong , Zhou Hong‐Cai 
Published: March 2015

AbstractA zeotype mesoporous zirconium metal‐organic framework, [Zr6(O)4(OH)10(H2O)6 (TATB)2] (TATB: 4,4′,4′′‐s‐triazine‐2,4,6‐triyl‐tribenzoate) is solvothermally prepared from a mixture of ZrOCl2, TATB, and TFA in N,N‐diethylformamide (autoclave, 120 °C, 12 h).
ChemInform Abstract: Parity‐Controlled Self‐Assembly of Supramolecular Helices in a Gold(I)—Copper(II) Coordination System with Penicillamine and Bis(diphenylphosphino)alkane
Authors: Yoshinari Nobuto , Kakuya Atsushi , Lee Raeeun , Konno Takumi 
Published: March 2015

AbstractReview: [25 refs.
ChemInform Abstract: Organoiron‐Mediated Synthesis and Redox Activity of Organoiron‐Containing Dendrimers
Authors: Astruc Didier , Wang Yanlan , Rapakousiou Amalia , Diallo Abdou , Djeda Rodrigue , Ruiz Jaime , Ornelas Catia 
Published: March 2015

AbstractReview: 88 refs.
ChemInform Abstract: DNAzyme‐Based Biosensors and Nanodevices
Authors: Gong Liang , Zhao Zilong , Lv Yi‐Fan , Huan Shuang‐Yan , Fu Ting , Zhang Xiao‐Bing , Shen Guo‐Li , Yu Ru‐Qin 
Published: March 2015

AbstractReview: 132 refs.
ChemInform Abstract: Pickering Interfacial Catalysis for Biphasic Systems: From Emulsion Design to Green Reactions
Authors: Pera‐Titus Marc , Leclercq Loic , Clacens Jean‐Marc , De Campo Floryan , Nardello‐Rataj Veronique 
Published: March 2015

AbstractReview: [recent examples of hybrid and composite amphiphilic materials for the design of interfacial catalysts in Pickering emulsions for industrially relevant biphasic reactions in fine chemistry, biofuel upgrading, and depollution; 87 refs.
Public health impact of achieving 80% colorectal cancer screening rates in the United States by 2018
Authors: Meester Reinier G. S. , Doubeni Chyke A. , Zauber Ann G. , Goede S. Luuk , Levin Theodore R. , Corley Douglas A. , Jemal Ahmedin , Lansdorp‐Vogelaar Iris 
Published: March 2015

BACKGROUNDThe National Colorectal Cancer Roundtable, a national coalition of public, private, and voluntary organizations, has recently announced an initiative to increase colorectal cancer (CRC) screening rates in the United States to 80% by 2018. The authors evaluated the potential public health benefits of achieving this goal.METHODSThe authors simulated the 1980 through 2030 United States population of individuals aged 50 to 100 years using microsimulation modeling. Test‐specific historical screening rates were based on National Health Interview Survey data for 1987 through 2013. The effects of increasing screening rates from approximately 58% in 2013 to 80% in 2018 were compared to a scenario in which the screening rate remained approximately constant. The outcomes were cancer incidence and mortality rates and numbers of CRC cases and deaths during short‐term follow‐up (2013‐2020) and extended follow‐up (2013‐2030).RESULTSIncreasing CRC screening rates to 80% by 2018 would reduce CRC incidence rates by 17% and mortality rates by 19% during short‐term follow‐up and by 22% and 33%, respectively, during extended follow‐up. These reductions would amount to a total of 277,000 averted new cancers and 203,000 averted CRC deaths from 2013 through 2030.CONCLUSIONSAchieving the goal of increasing the uptake of CRC screening in the United States to 80% by 2018 may have a considerable public health impact by averting approximately 280,000 new cancer cases and 200,000 cancer deaths within <20 years. Cancer 2015;121:2281–2285. © 2015 The Authors. Cancer published by Wiley Periodicals, Inc. on behalf of American Cancer Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
Interaction of Globular Plasma Proteins with Water‐Soluble CdSe Quantum Dots
Authors: Pathak Jyotsana , Rawat Kamla , Sanwlani Shilpa , Bohidar H. B. 
Published: March 2015

AbstractThe interactions between water‐soluble semiconductor quantum dots [hydrophilic 3‐mercaptopropionic acid (MPA)‐coated CdSe] and three globular plasma proteins, namely, bovine serum albumin (BSA), β‐lactoglobulin (β‐Lg) and human serum albumin (HSA), are investigated. Acidic residues of protein molecules form electrostatic interactions with these quantum dots (QDs). To determine the stoichiometry of proteins bound to QDs, we used dynamic light scattering (DLS) and zeta potential techniques. Fluorescence resonance energy transfer (FRET) experiments revealed energy transfer from tryptophan residues in the proteins to the QD particles. Quenching of the intrinsic fluorescence of protein molecules was noticed during this binding process (hierarchy HSA<β‐Lg <BSA, lower binding affinity for hydrophobic protein molecules). Upon binding with QD particles, the protein molecules underwent substantial conformational changes at the secondary‐structure level (50 % helicity lost), due to loss in hydration.