bluuebunny/crossref_metadata_2025_split huggingface dataset:
Inhibitory effects of interferon‐β on hepatocellular carcinoma HepG2 via Akt/STAT phosphorylation
Authors: Ethiraj Purushoth , Veerappan Karpagam , Samuel Shila , Sivapatham Sundaresan 
Published: March 2015

AbstractConventional chemotherapy fails to cure metastatic hepatoma mainly due to its high hepatotoxicity. Currently, doxorubicin is the most widely used drug against liver cancer either as single agent or in combination with other chemotherapeutics such as cisplatin. It is limited due to their severe toxicity on normal hepatocytes. Therefore, alternative therapeutic agents without or with low hepatotoxicity are highly desirable. Interferons are a family of cytokines that potently demonstrate antiviral, immunomodulatory, and antiproliferative activities. It also exerts direct cytotoxic effects on tumor cells. The purpose of this study was to examine the in vitro cytotoxicity of interferon‐β on HepG2 cells. We revealed the presence of binding receptor of interferon‐β in HepG2 cells. The dose‐dependent inhibition on cell proliferation was observed. We demonstrated that IFN‐β exhibited significant cytotoxicity in HepG2 cells mainly through phosphorylation of signal transducers and activators of transcription 2. The activation of Akt was suppressed. The stimulation of pro‐apoptotic protein expression of Bax, inhibition of anti‐apoptotic protein expression of Bcl‐2, activation of cleaved caspases 9 and 3 was found at increasing concentrations. In conclusion, our results suggest that interferon‐β has potential to inhibit cell proliferation dose dependently. Increased concentrations of interferon‐β influenced apoptosis via mitochondrial pathway through inhibition of p‐Akt.
Evaluation of angler reporting accuracy in an off‐site survey to estimate statewide steelhead harvest
Authors: McCormick J. L. , Whitney D. , Schill D. J. , Quist M. C. 
Published: March 2015

AbstractAccuracy of angler‐reported data on steelhead, Oncorhynchus mykiss (Walbaum), harvest in Idaho, USA, was quantified by comparing data recorded on angler harvest permits to the numbers that the same group of anglers reported in an off‐site survey. Anglers could respond to the off‐site survey using mail or Internet; if they did not respond using these methods, they were called on the telephone. A majority of anglers responded through the mail, and the probability of responding by Internet decreased with increasing age of the respondent. The actual number of steelhead harvested did not appear to influence the response type. Anglers in the autumn 2012 survey overreported harvest by 24%, whereas anglers in the spring 2013 survey under‐reported steelhead harvest by 16%. The direction of reporting bias may have been a function of actual harvest, where anglers harvested on average 2.6 times more fish during the spring fishery than the autumn. Reporting bias that is a function of actual harvest can have substantial management and conservation implications because the fishery will be perceived to be performing better at lower harvest rates and worse when harvest rates are higher. Thus, these findings warrant consideration when designing surveys and evaluating management actions.
Landing profiles of Portuguese fisheries: assessing the state of stocks
Authors: Leitão F. 
Published: March 2015

AbstractLong‐term trends in Portuguese fisheries landing profiles of biodiversity, assemblage composition, trophic groups and marine trophic index (1950–2009) were studied to understand the evolution of the fisheries from an ecological viewpoint and evaluate the effects of fisheries on stocks. The number of species landed has increased considerably since the 1980s. This indicates an expansion of the fisheries and also a better use of the marine biodiversity for redistributing effort. Changes in the ecological composition of fisheries catches have occurred since the 1950s, with a significant shift in the middle 1980s (anchor point). Deep‐sea resources and higher trophic levels (cephalopods, large benthopelagics, flatfishes, demersal invertebrates, small‐medium and large rays, medium bathydemersal, shrimps, small benthopelagics large sharks) have increased while traditional commercial species captured by nearshore fisheries (medium and small pelagics) have decreased. Despite the decreasing trend in catches since 1988, the marine trophic index (MTI = 3.04) increased by approximately 0.2 units per decade (MTI in 2009 = 3.46). The number of collapsed, overexploited and fully exploited stocks has increased considerably over the last 20 years (>50%). Overall, the data indicate that redistributing fishing effort and targeting of deep‐sea resources may have been driven by depletion of inshore fishery stocks, which signals concern for the fishery. Marine biodiversity indexes and ecological structure of landings profiles should be considered by fishery managers when redefining new marine fisheries policy.
Lack of replication for the myosin‐18B association with mathematical ability in independent cohorts
Authors: Pettigrew K. A. , Fajutrao Valles S. F. , Moll K. , Northstone K. , Ring S. , Pennell C. , Wang C. , Leavett R. , Hayiou‐Thomas M. E. , Thompson P. , Simpson N. H. , Fisher S. E. ,   The SLI Consortium, Whitehouse A. J. O. , Snowling M. J. , Newbury D. F. , Paracchini S. 
Published: March 2015

AbstractTwin studies indicate that dyscalculia (or mathematical disability) is caused partly by a genetic component, which is yet to be understood at the molecular level. Recently, a coding variant (rs133885) in the myosin‐18B gene was shown to be associated with mathematical abilities with a specific effect among children with dyslexia. This association represents one of the most significant genetic associations reported to date for mathematical abilities and the only one reaching genome‐wide statistical significance. We conducted a replication study in different cohorts to assess the effect of rs133885 maths‐related measures. The study was conducted primarily using the Avon Longitudinal Study of Parents and Children (ALSPAC), (N = 3819). We tested additional cohorts including the York Cohort, the Specific Language Impairment Consortium (SLIC) cohort and the Raine Cohort, and stratified them for a definition of dyslexia whenever possible. We did not observe any associations between rs133885 in myosin‐18B and mathematical abilities among individuals with dyslexia or in the general population. Our results suggest that the myosin‐18B variant is unlikely to be a main factor contributing to mathematical abilities.
Comovements of ethanol‐related prices: evidence from Brazil and the USA
Authors: Kristoufek Ladislav , Janda Karel , Zilberman David 
Published: March 2015

AbstractWe use the wavelet coherence methodology to investigate the relations between prices of ethanol and its feedstocks. Our continuous wavelet framework allows for discovering price connections and their evolution in both time and frequency domain in the most important ethanol markets – Brazil and the USA. For both of these markets, we show that the long‐run relationship between prices of ethanol and corn (in the USA) or sugar (in Brazil) is positive, strong and stable in time. Importantly, we show that the prices of feedstock lead the prices of ethanol and not the other way around. The price lead of feedstock is documented for both short‐ and long‐run horizons. Our qualitative results hold true even when the influence of crude oil prices is accounted for by utilizing partial wavelet coherence approach.
Pyoderma gangrenosum associated with solid organ malignancies
Authors: Shahi Varun , Wetter David A. 
Published: March 2015

AbstractBackgroundPyoderma gangrenosum (PG) can be associated with systemic diseases, including inflammatory bowel disease, inflammatory arthritis, and hematologic malignancy. Previous literature exploring the rare association between PG and solid organ malignancy is predominantly limited to single case reports.MethodsWe retrospectively reviewed the cases of five patients with PG and solid organ malignancies at our institution between 1996 and 2013.ResultsFor the five patients identified, PG and solid organ malignancy occurred within three months of each other. Mean age at onset of PG was 55.6 years, and four patients were women. Three patients had breast carcinoma (one was recurrent), and two had gastrointestinal carcinoma. PG occurred before (n = 2), after (n = 2), or synchronously with (n = 1) the malignancy. In one patient with a history of PG and quiescent inflammatory bowel disease, recurrent PG developed synchronously with a new diagnosis of metastatic rectosigmoid carcinoma. Three patients had partial or complete response of PG with treatment of PG alone.ConclusionsTo our knowledge, our study is the first to report that the onset of PG can herald a recurrence of a solid organ malignancy and that recurrent PG can be associated with solid organ malignancy. A possible association of solid organ malignancy and PG should be considered in patients with PG of unknown etiology or with a history of malignancy.
Solitaire™ with the Intention for Thrombectomy as Primary Endovascular Treatment for Acute Ischemic Stroke (SWIFT PRIME) Trial: Protocol for a Randomized, Controlled, Multicenter Study Comparing the Solitaire Revascularization Device with IV tPA with IV tPA Alone in Acute Ischemic Stroke
Authors: Saver Jeffrey L. , Goyal Mayank , Bonafe Alain , Diener Hans-Christoph , Levy Elad I. , Pereira Vitor M. , Albers Gregory W. , Cognard Christophe , Cohen David J. , Hacke Werner , Jansen Olav , Jovin Tudor G. , Mattle Heinrich P. , Nogueira Raul G. , Siddiqui Adnan H. , Yavagal Dileep R. , Devlin Thomas G. , Lopes Demetrius K. , Reddy Vivek , de Rochemont Richard du Mesnil , Jahan Reza ,   for the SWIFT PRIME Investigators
Published: March 2015

Rationale Early reperfusion in patients experiencing acute ischemic stroke is critical, especially for patients with large vessel occlusion who have poor prognosis without revascularization. Solitaire™ stent retriever devices have been shown to immediately restore vascular perfusion safely, rapidly, and effectively in acute ischemic stroke patients with large vessel occlusions. Aim The aim of the study was to demonstrate that, among patients with large vessel, anterior circulation occlusion who have received intravenous tissue plasminogen activator, treatment with Solitaire revascularization devices reduces degree of disability 3 months post stroke. Design The study is a global multicenter, two-arm, prospective, randomized, open, blinded end-point trial comparing functional outcomes in acute ischemic stroke patients who are treated with either intravenous tissue plasminogen activator alone or intravenous tissue plasminogen activator in combination with the Solitaire device. Up to 833 patients will be enrolled. Procedures Patients who have received intravenous tissue plasminogen activator are randomized to either continue with intravenous tissue plasminogen activator alone or additionally proceed to neurothrombectomy using the Solitaire device within six-hours of symptom onset. Study Outcomes The primary end-point is 90-day global disability, assessed with the modified Rankin Scale (mRS). Secondary outcomes include mortality at 90 days, functional independence (mRS ≤ 2) at 90 days, change in National Institutes of Health Stroke Scale at 27 h, reperfusion at 27 h, and thrombolysis in cerebral infarction 2b/3 flow at the end of the procedure. Analysis Statistical analysis will be conducted using simultaneous success criteria on the overall distribution of modified Rankin Scale (Rankin shift) and proportions of subjects achieving functional independence (mRS 0–2).
Nursing staff induced repositionings and immobile patients' spontaneous movements in nursing care
Authors: Källman Ulrika , Bergstrand Sara , Ek Anna‐Christina , Engström Maria , Lindgren Margareta 
Published: March 2015

AbstractThe aim of this study was to investigate nursing staff induced repositionings and the patients' spontaneous movements during the day and night among older immobile patients in nursing care. Furthermore, the aim was to identify factors associated with the nursing staff induced repositionings and the patients' spontaneous movement frequency. An observational cross‐sectional design was used. Spontaneous movements among patients (n = 52) were registered continuously using the MovinSense monitoring system. The nursing staff documented each time they repositioned the patient. Patients spontaneous movements were compared with nursing staff induced repositionings. There were large variations in the patients' spontaneous repositioning frequency during both days and nights, which shows that, although immobilised, some patients frequently reposition themselves. Analgesics were positively related to the movement frequency and psycholeptics were negatively related. The nursing staff more often repositioned the patients who were assessed as high risk than those assessed as low risk, but the patients' spontaneous movement frequency was not correlated to the risk score. This may be important when planning repositioning schedules. A monitoring system may be useful in decision making with regard to planning repositioning and positions used in the prevention of pressure ulcers among elderly immobile patients.
Yes, we can: physical activity and group identification among healthy adults
Authors: Grant Fiona , Hogg Michael A. , Crano William D. 
Published: March 2015

AbstractDrawing on social identity theory and social cognitive theory, this research was designed to investigate the role played by group identification, self‐efficacy and outcome expectations in physical activity behavior. Healthy adult participants (N = 130) who identified strongly with an exercise referent group reported higher levels of physical activity, and this relationship was mediated by self‐efficacy and outcome expectations. This study adds to the existing literature on the effects of social groups on health and is one of the first to examine the interplay of personal factors and group membership on physical activity.
Characteristics of Systemic Hypertension in Preterm Children
Authors: Shah Ankur B. , Hashmi S. Sharukh , Sahulee Raj , Pannu Hariyadarshi , Gupta‐Malhotra Monesha 
Published: March 2015

The prevalence of essential hypertension (EH) among preterm children is unknown. The authors evaluated consecutive children with a diagnosis of hypertension and prematurity (gestational age <37 weeks) in a tertiary pediatric hypertension clinic and identified 36 preterm hypertensive children. Among these preterm children, 23 were diagnosed in the neonatal intensive care unit (NICU; infantile) and 13 were diagnosed at an older age (childhood). When compared with patients with a childhood diagnosis, patients with an infantile diagnosis had a significantly lower gestational age, longer duration of hospitalization in the NICU, and a higher incidence of perinatal risk factors for hypertension. None with infantile diagnosis had EH, whereas 46% with childhood diagnosis had EH. Among premature children, systemic hypertension was either diagnosed in infancy or in childhood, with each age at diagnosis having unique risk factors and clinical course. Although 83% of preterm children had secondary hypertension, EH was diagnosed in 17% and was only seen in those diagnosed beyond infancy.
Distribution of intestinal metaplasia as a predictor of gastric cancer development
Authors: Shichijo Satoki , Hirata Yoshihiro , Sakitani Kosuke , Yamamoto Shinzo , Serizawa Takako , Niikura Ryota , Watabe Hirotsugu , Yoshida Shuntaro , Yamada Atsuo , Yamaji Yutaka , Ushiku Tetsuo , Fukayama Masashi , Koike Kazuhiko 
Published: March 2015

AbstractBackground and AimHelicobacter pylori, gastritis, and intestinal metaplasia (IM) are known risk factors for gastric cancer. In the present study, we conducted a cohort study to evaluate the predictive value of the distribution of IM for gastric cancer development.MethodsWe conducted a retrospective cohort study at a university hospital. From June 1998 to December 2000, we assessed histological gastritis using biopsy specimens, one from the antrum and one from the corpus, from 1450 patients, among whom 729 revisited for follow‐up endoscopy. Patients were classified into three groups according to the distribution of IM at initial endoscopy. IM group A had no IM, IM group B had IM in the antrum only, and IM group C had IM in the corpus. The development of gastric cancer was assessed by endoscopic examination.ResultsThe mean duration of follow‐up was 6.7 ± 4.7 years. The cumulative incidence of gastric cancer at 5 years was 1.5% in total and 0.8%, 3.3%, and 2.7% in IM groups A, B, and C, respectively. The IM group was identified as an independent risk factor by multivariate analysis; compared with IM group A, hazard ratios were 3.6 (95% confidence interval [CI] 1.1–12.1) in IM group B and 3.8 (95% CI 1.01–14.1) in IM group C. In IM group C, the incidence of gastric cancer in patients who received eradication therapy was significantly lower than that in patients who did not receive (P = 0.021, log‐rank).ConclusionIM is a good predictive marker for the development of gastric cancer.
Appearance of hepatobiliary diseases in a population‐based cohort with inflammatory bowel diseases (Inflammatory Bowel Disease Cohort of the Uppsala Region)
Authors: Rönnblom Anders , Holmström Tommy , Tanghöj Hans , Rorsman Fredrik , Sjöberg Daniel 
Published: March 2015

AbstractBackground and AimTo prospectively follow the evolution of hepatobiliary diseases in a population‐based cohort of patients with inflammatory bowel diseases.MethodsBetween 2005 and 2009, 790 incident cases of ulcerative colitis and Crohn's disease were registered in the Uppsala Health Region, corresponding to an average incidence of 20.0 and 9.9 new cases/100 000 inhabitants/year, respectively. Liver function tests were analyzed in 97.1% and the results of ensuing investigations were summarized.ResultsSeventeen patients with primary sclerosing cholangitis were diagnosed corresponding to an overall prevalence of 2.2% (ulcerative colitis 1.7% and Crohn's disease 3.0%, respectively). The median age at diagnosis was 25 years (interquartile range: 17.0–34.0). Among the 92 patients below 17 years of age, three had autoimmune hepatitis and three primary sclerosing cholangitis, summing up to a prevalence of 6.5% immune‐mediated hepatobiliary diseases among the pediatric patients. Three patients have undergone liver transplantation and one died of colonic carcinoma. Ten patients have demonstrated persistent elevation of alkaline phosphatases but had a normal magnetic resonance cholangiopancreatography (two patients) or refused further investigation (one patient).ConclusionIn this first large prospective population‐based cohort of 526 patients with ulcerative colitis (UC) and 264 with Crohn's disease, 17 cases of primary sclerosing cholangitis were found, among whom three (17%) so far have been liver transplanted and one has died of colon carcinoma. The average age of those affected by primary sclerosing cholangitis is considerably lower than usually reported. Ten patients had or have had elevated alkaline phosphatase without confirmed liver or biliary disease.
Adverse pregnancy outcome in patients with low pregnancy‐associated plasma protein‐A: The Indian Experience
Authors: Gupta Sangeeta , Goyal Manisha , Verma Deepti , Sharma Anjana , Bharadwaj Namita , Kabra Madhulika , Kapoor Seema 
Published: March 2015

AbstractAimThe aim of our study was to examine the association of low pregnancy‐associated plasma protein‐A (PAPP‐A) with adverse pregnancy outcome.Material and MethodsA total of 1640 consecutive pregnant women between 9+5 and 13+6 weeks of pregnancy were recruited. One hundred and thirty women with PAPP‐A levels < 0.4 multiple of median were followed till delivery and the outcome information was obtained for fetal loss, birthweight, growth restriction, preterm birth, reduced liquor and development of pre‐eclampsia.ResultsDuring the study period, 130 (7.92%) women had low PAPP‐A and were considered as cases and 200 women with normal PAPP‐A were controls. Intrauterine growth restriction was observed in 28 (21.54%) cases as compared to 10 (5%) controls. Pre‐eclampsia presented in 24 (18.46%) cases and in 18 (9%) controls. Twenty (15.38%) cases had preterm delivery compared to 12 (6%) controls. Fifty‐six (43.08%) cases delivered low‐birthweight babies compared to 22 (11%) controls. Thus, the incidence of intrauterine growth restriction, preterm birth and low birthweight was significantly more in the cases as compared to the control group.ConclusionsPAPP‐A is a valuable analyte for predicting risk of adverse pregnancy outcome and women with low serum PAPP‐A levels would benefit from closer surveillance.
Opsoclonus–ataxia syndrome associated with ovarian mature teratoma
Authors: Kanno Kiyoshi , Kin Syogo , Hirose Masaki , Suzuki Satoshi , Watanabe Takafumi , Fujimori Keiya 
Published: March 2015

AbstractA 16‐year‐old girl with no prior medical history developed vertigo and nausea following alimentary infection. Neurological examination showed limb and truncal ataxia, opsoclonus, myoclonus, and hyperreflexia. Brain magnetic resonance imaging and cerebrospinal fluid analysis showed no abnormalities. Treatment with i.v. high‐dose methylprednisolone and immunoglobulin was started, but this proved ineffective. The clinical course was unusual, so whole‐body computed tomography was done to evaluate other differential diagnoses. Imaging identified right ovarian mature teratoma. Paraneoplastic opsoclonus–ataxia syndrome was suspected, therefore single‐incision laparoscopic ovarian cystectomy was done 10 days after admission. Two months after therapy, the patient had complete recovery and remained asymptomatic at 1 year after onset. Serum testing for anti‐neuronal antibodies was negative, including for anti‐N‐methyl‐d‐aspartate‐receptor antibody. Young women with ataxia and opsoclonus of unclear etiology should be examined for the presence of ovarian teratoma, then intensive immunotherapy and prompt tumor resection can lead to good clinical outcome.
Getting “Bi” in the Family: Bisexual People's Disclosure Experiences
Authors: Scherrer Kristin S. , Kazyak Emily , Schmitz Rachel 
Published: March 2015

AbstractThere are many similarities in gay, lesbian, and bisexual individuals' coming out experiences, but bisexual people face unique challenges. Despite this, an explicit focus on bisexual people is missing from family research. Using family systems and cultural sociological perspectives, the authors analyzed how social and cultural factors shape disclosure processes for bisexuals as they come out to multiple family members. After analyzing qualitative data from a diverse group of 45 individuals, they found that bisexual people navigate monosexist and heterosexist expectations in their family relationships. Cultural constructions of bisexuality shape the ways that bisexual people disclose their identities, including how they use language to influence family members' responses in desirable ways. Relationship status also influences bisexual people's disclosure strategies, as a romantic partner's gender is meaningful to family members' understandings of their sexual orientation. The findings highlight the importance of addressing cultural and social contexts in understanding sexual minority people's coming out processes.