bluuebunny/crossref_metadata_2025_split huggingface dataset:
Acute Cytomegalovirus infection as a cause of venous thromboembolism
Authors: Lissandrin Raffaella , Mojoli Francesco , Baldanti Fausto , Brunetti Enrico , Pascarella Michela , Giordani Maria Teresa , Rinaldi Francesca 
Published: June 2014

Acute Human Cytomegalovirus (HCMV) Infection is an unusual cause of venous thromboembolism, a potentially life-threatening condition. Thrombus formation can occur at the onset of the disease or later during recovery and may also occur in the absence of acute HCMV hepatitis. It is likely due to both vascular endothelium damage caused by HCMV and impairment of the clotting balance caused by the virus itself. Here we report on two immunocompetent women with splanchnic thrombosis that occurred during the course of acute HCMV infection. Although the prevalence of venous thrombosis in patients with acute HCMV infection is unknown, physicians should be aware of its occurrence, particularly in immune-competent patients presenting with fever and unexplained abdominal pain referred to the splanchnic region.
“Fiction or death”: Novels of the Children of the Detained-disappeared as Vehicles for Mourning
Authors: Nuckols Anthony 
Published: June 2014

Resumen:El presente artículo propone una lectura de las novelas escritas por los hijos de detenidos-desaparecidos argentinos como instrumentos de duelo. A través de la ficción como testimonio, el lector deviene testigo de la vivencia de la catástrofe del narrador, lo que resulta en un acto de rememoración central en el duelo hecho a través de la literatura. Las novelas que analizamos aquí, Los topos de Félix Bruzzone y Diario de una princesa montonera de Mariana Eva Perez, constituyen un cruce de caminos de testimonios: el testimonio heredado de los padres desaparecidos, el testimonio de crecer como hijos de desaparecidos, y el testimonio creado en el lector a través del acto de la lectura.Palabras claves: duelo, ficción, testimonio,rememoración, desaparecidos.Abstract: The present article proposes an understanding of the novels written by children of the Argentinean detained-disappeared as instruments for mourning. Through fiction as testimony, the reader bears witness to the narrator’s living within the catastrophe of the detained-disappeared, resulting in an act of remembrance that is at the very center of the work of mourning through literature. The novels that we analyze here, Los topos by Félix Bruzzone and Diario de una princesa montonera by Mariana Eva Perez, constitute a crossroads of testimony: the inherited testimony of the disappeared parents, the testimony of growing up as children of the disappeared, and the reader’s testimony created in the act of reading.Key Words: mourning, fiction, testimony,remembrance, disappeared.
Configuraciones discursivas de Abuelas de Plaza de Mayo: enunciación y mecanismos retóricos en 'Botín de guerra'
Authors: Quintana María Marta 
Published: June 2014

Resumen: En el presente artículo se busca analizar de qué manera el primer texto institucional de Abuelas de Plaza de Mayo, Botín de guerra (1985), configura una trama de sentido, una puesta en orden de los acontecimientos, frente al vacío y a la dislocación ontológica generada por la desaparición de niños/as –y de adultos- durante la última dictadura militar argentina (1976-1983), a la par que constituye, performativamente, una irrupción en la escena pública de la Asociación. A tal efecto, abordando el corpus como un dispositivo genérico, retórico y enunciativo, se profundiza, desde diferentes entradas analíticas, cómo –en la propia situación discursiva- se produce una progresiva rearticulación simbólica en términos de conocimiento y agencia política. Palabras clave: Abuelas de Plaza de Mayo; Botín de guerra; desaparición; dislocación; configuraciones discursivas. Abstract: This article analyzes how the first institutional text of Grandmothers of Plaza de Mayo, Botín de guerra (Spoils of War) (1985), configures a frame of meaning, an ordering of events –of both the kidnappings and the searches– in the face of the vacuum and the ontological dislocation created by the disappearance of children during Argentina’s last military dictatorship (1976-1983). And at the same time, the text constitutes a perfomative emergence of the Association in the public scene. The study approaches the corpus as a generic, rhetorical and enunciative dispositif, and from different analytical standpoints, looks more deeply into the development of a progressive symbolic re-articulation –in the discursive situation itself– in terms of knowledge and political agency. Key Words: Grandmothers of Plaza de Mayo; Spoils of War; disappearance; dislocation; discursive configuration.
Mycoplasma
Authors: Balish Mitchell F. , Chopra‐Dewasthaly Rohini , Pereyre Sabine , Ramírez Ana S. , Viver Tomeu , Spergser Joachim 
Published: July 2024

Abstract

My.co.plas'ma. Gr. masc. n.
mykês
, mushroom or other fungus; Gr. neut. n.
plasma
, anything formed or molded, image, figure; N.L. neut. n.
Mycoplasma
, fungus form.

Bacillota_I / Bacilli_A / Mycoplasmatales / Mycoplasmataceae / Mycoplasma

Bacteria in the genus
Mycoplasma
are small (300–800 nm in diameter) pleomorphic cells devoid of a cell wall. Culturable species usually form very small (<1 mm) umbonate colonies on agar. Their use of the codon UGA to encode tryptophan is a distinctive characteristic of all species examined to date. As a consequence of their small (usually 0.5–1.5 Mb) genomes they have limited intermediary metabolism and are nutritionally fastidious, requiring exogenous carbohydrates or arginine, fatty acids, cholesterol or other sterols, peptides, cofactors, and free nucleic acids for axenic growth. In nature, all species are obligate commensals or parasites with varying degrees of specificity for a wide range of vertebrate hosts. The type species
Mycoplasma mycoides
subsp.
mycoides
and
Mycoplasma capricolum
subsp.
capripneumoniae
are highly virulent animal pathogens subject to strict international regulations, but the genus is perhaps better known for
Mycoplasma pneumoniae
, the agent of primary atypical “walking” pneumonia in humans. The relative biological simplicity of mycoplasmas confers significant advantages for current proteomics, metabolomics, synthetic genomics, and systems biology research. For example, the recent chemical synthesis and transplantation of intact chromosomes demonstrated that it is possible to enliven a mycoplasma fully capable of autonomous replication with an artificially constructed genome.

DNA G + C content (mol%)
: 23–40.

Type species
:
Mycoplasma mycoides
Freundt 1955
AL
(basonym:
Asterococcus mycoides
Borrel et al. 1910.
An Untethered Heart Rhythm Monitoring System with Automated AI‐Based Arrhythmia Detection for Closed‐Loop Experimental Application
Authors: Deng Shanliang , den Ouden Bram L , De Coster Tim , Bart Cindy I , Bax Wilhelmina H , Poelma René H , de Vries Antoine AF , Zhang Guo Qi , Portero Vincent , Pijnappels Daniël A 
Published: July 2024

AbstractThe heart produces bioelectrical signals, which can be measured as an electrocardiogram (ECG) for the detection of rhythm disturbances. Rapid and precise detection of these arrhythmias is crucial for their termination by closed‐looped therapeutic interventions to counteract detrimental effects. However, there is a current lack of such systems tailored for experimental cardiovascular applications. This hampers not only in‐depth mechanistic studies but also translational testing of new therapeutic strategies, especially in an untethered manner in awake animal models. To break new ground, recent advances to develop a non‐invasive AI‐supported heart rhythm monitoring system for untethered automated arrhythmia detection in a continuous manner is combined. This system is housed in a lightweight jacket for mobile use and includes an on‐skin ECG sensor, a low‐power microprocessor unit, a massive data storage unit, and a power‐management system. By implementing a novel hybrid algorithm based on so‐called heart rate (R‐R) variability and a case‐specific AI model, 100% sensitivity and 95% specificity is achieved in detecting atrial arrhythmias within 2 s upon initiation in adult rats. Thereby, the novel system sets the stage for advanced mechanistic studies and therapeutic testing, including closed‐loop applications aiming for the termination of a broad range of atrial arrhythmias.
Uncovering the Elusive Structures and Mechanisms of Prevalent Antidepressants
Authors: Lin Jieye , Bu Guanhong , Unge Johan , Gonen Tamir 
Published: July 2024

AbstractMost treatments to alleviate major depression work by either inhibiting human monoamine transporters, vital for the reuptake of monoamine neurotransmitters, or by inhibiting monoamine oxidases, which are vital for their degradation. The analysis of the experimental 3D structures of those antidepressants in their drug formulation state is key to precision drug design and development. In this study, microcrystal electron diffraction (MicroED) is applied to reveal the atomic 3D structures for the first time of five of the most prevalent antidepressants (reboxetine, pipofezine, ansofaxine, phenelzine, and bifemelane) directly from the commercially available powder of the active ingredients. Their modes of binding are investigated by molecular docking, revealing the essential contacts and conformational changes into the biologically active state. This study underscores the combined use of MicroED and molecular docking to uncover elusive drug structures and mechanisms to aid in further drug development pipelines.
Extracellular Matrix Sulfation in the Tumor Microenvironment Stimulates Cancer Stemness and Invasiveness
Authors: Kuşoğlu Alican , Örnek Deniz , Dansık Aslı , Uzun Ceren , Nur Özkan Sena , Sarıca Sevgi , Yangın Kardelen , Özdinç Şevval , Sorhun Duygu Turan , Solcan Nuriye , Doğanalp Efe Can , Arlov Øystein , Cunningham Katherine , Karaoğlu Ismail C. , Kizilel Seda , Solaroğlu Ihsan , Bulutay Pınar , Fırat Pınar , Erus Suat , Tanju Serhan , Dilege Şükrü , Vunjak‐Novakovic Gordana , Tuncbag Nurcan , Öztürk Ece 
Published: July 2024

AbstractTumor extracellular matrices (ECM) exhibit aberrant changes in composition and mechanics compared to normal tissues. Proteoglycans (PG) are vital regulators of cellular signaling in the ECM with the ability to modulate receptor tyrosine kinase (RTK) activation via their sulfated glycosaminoglycan (sGAG) side chains. However, their role on tumor cell behavior is controversial. Here, it is demonstrated that PGs are heavily expressed in lung adenocarcinoma (LUAD) patients in correlation with invasive phenotype and poor prognosis. A bioengineered human lung tumor model that recapitulates the increase of sGAGs in tumors in an organotypic matrix with independent control of stiffness, viscoelasticity, ligand density, and porosity, is developed. This model reveals that increased sulfation stimulates extensive proliferation, epithelial‐mesenchymal transition (EMT), and stemness in cancer cells. The focal adhesion kinase (FAK)‐phosphatidylinositol 3‐kinase (PI3K) signaling axis is identified as a mediator of sulfation‐induced molecular changes in cells upon activation of a distinct set of RTKs within tumor‐mimetic hydrogels. The study shows that the transcriptomic landscape of tumor cells in response to increased sulfation resembles native PG‐rich patient tumors by employing integrative omics and network modeling approaches.
Programmable Carbon Nanotube Networks: Controlling Optical Properties Through Orientation and Interaction
Authors: Voronin Kirill V. , Ermolaev Georgy A. , Burdanova Maria G. , Slavich Aleksandr S. , Toksumakov Adilet N. , Yakubovsky Dmitry I. , Paukov Maksim I. , Xie Ying , Qian Liu , Kopylova Daria S. , Krasnikov Dmitry V. , Ghazaryan Davit A. , Baranov Denis G. , Chernov Alexander I. , Nasibulin Albert G. , Zhang Jin , Arsenin Aleksey V. , Volkov Valentyn 
Published: July 2024

AbstractThe lattice geometry of natural materials and the structural geometry of artificial materials are crucial factors determining their physical properties. Most materials have predetermined geometries that lead to fixed physical characteristics. Here, the demonstration of a carbon nanotube network serves as an example of a system with controllable orientation achieving on‐demand optical properties. Such a network allows programming their optical response depending on the orientation of the constituent carbon nanotubes and leads to the switching of its dielectric tensor from isotropic to anisotropic. Furthermore, it also allows for the achievement of wavelength‐dispersion for their principal optical axes – a recently discovered phenomenon in van der Waals triclinic crystals. The results originate from two unique carbon nanotubes features: uniaxial anisotropy from the well‐defined cylindrical geometry and the intersection interaction among individual carbon nanotubes. The findings demonstrate that shaping the relative orientations of carbon nanotubes or other quasi‐one‐dimensional materials of cylindrical symmetry within a network paves the way to a universal method for the creation of systems with desired optical properties.
Near‐infrared spectroscopy and deep neural networks for early common root rot detection in wheat from multi‐season trials
Authors: Xiong Yiyi , McCarthy Cheryl , Humpal Jacob , Percy Cassandra 
Published: July 2024

AbstractIn Australia, the soil‐borne disease common root rot (Bipolaris sorokiniana) (CRR) in wheat (Triticum aestivum L.) leads to substantial yield losses, yet has limited visible aboveground symptoms, making detection and identification labor intensive. Near‐infrared (NIR) spectroscopy offers an early potential identification solution for CRR in wheat and has previously been reported with success for crop disease detection. This study investigated the ability of nondestructive NIR spectroscopy in combination with deep neural networks (DNN), logistic regression (LR), and principal component analysis combined with support vector machines (PCA‐SVM) for early‐stage CRR detection in wheat. NIR spectra of five different wheat varieties with varying resistance to CRR were collected in two seasons of glasshouse and three seasons of field trials using a portable spectrometer. Results demonstrated that DNN outperformed LR and PCA‐SVM, achieving 66%–91% average classification accuracy in glasshouse trials and an average accuracy of 73% with up to 87% in field trials, effectively distinguishing inoculated and non‐inoculated wheat plants from seedling to anthesis stages. Validation with a third season of field data achieved an average of 77% accuracy for the most susceptible variety during the stem elongation stage. NIR reflectance within 1600–1700 nm was identified as most important for estimating CRR presence, with initial detection occurring 35 days after sowing (DAS) in the glasshouse and 46 DAS in the field. In conclusion, a NIR spectrometer with a DNN model successfully performed disease classification, with the potential as a portable early disease detection tool to assist farm management decisions.
Mono‐ and bis(steroids) containing a cyclooctane core: Synthesis, antiproliferative activity, and action on cell cytoskeleton microtubules
Authors: Ryzhikova Olga V. , Churkina Aleksandra S. , Sedenkova Kseniya N. , Savchenkova Daiana V. , Shakhov Anton S. , Lavrushkina Svetlana V. , Grishin Yuri K. , Zefirov Nikolay A. , Zefirova Olga N. , Gracheva Yulia A. , Milaeva Elena R. , Alieva Irina B. , Averina Elena B. 
Published: July 2024

AbstractSteroid dimers of natural and synthetic origin possess an unusual and complex molecular architecture that may lead to the realization of peculiar effects in biological systems, in particular in different cancer cell lines. In the present work, diastereoselective ring‐opening of mono‐ and polyoxiranes, containing a cyclooctane core, by azide‐anion was performed to yield a series of azidoalcohols with different types of symmetry. The products were involved in copper‐catalyzed azyde‐alkyne cycloaddition (CuAAC) reaction with ethinylestradiol and ethinyltestosterone, and the resulting steroids and steroid dimers with triazole linkers were screened for their antiproliferative activity via (3‐(4,5‐dimethylthiazol‐2‐yl)2,5‐diphenyl tetrazolium bromide) assay. All the compounds revealed cytotoxicity toward several cancer cell lines. The effect of the most potent compound, containing two estradiol moieties, on the microtubules (MT) dynamics was investigated by immunofluorescent microscopy. The disruption of the majority of interphase cell cytoplasmic MT and mitotic event disturbances in the presence of the studied compound were observed. The latter effect caused the appearance of numerous multinucleated cells.
Functionalization of a [2]Catenane with Donor‐Acceptor Chromophores Using a Metal Template and Click Reactions
Authors: Ghosh Priyanka , Ratha Radhakrishna , Shekhar Purohit Chandra 
Published: July 2024

AbstractSynthesizing molecules with significant topological features, such as catenanes, tailored with specific groups to confer desired functionality, is essential for investigating various properties arising from the entanglement due to mechanical bonds. This investigation can pave the way for uncovering novel functional materials employing mechanically interlocked molecules (MIMs). In this direction, we have synthesized a π‐donor (D) and π‐acceptor (A) functionalized [2]catenane using a non‐labile Co(III) metal ion as a template with pyridine‐diamide templating center and utilizing click reaction for ring‐closing. The donor group is a fluorene derivative, and the acceptor is a benzophenazine derivative, commonly employed in synthesizing conjugated polymers for various optoelectronic devices. Synthetically, the acceptor group was introduced into a macrocycle with a pyridine diamide unit. It was then threaded with a ligand having alkyne terminals to obtain the desired [2]pseudorotaxane utilizing cobalt ion as a template. Ring‐closing was then performed with a di‐azide functionalized molecule with the donor chromophore. The desired D−A functionalized [2]catenane was obtained after demetalation. All the starting materials, macrocycle, and entangled structures have been characterized by 1H‐NMR, 13C‐NMR, and mass spectroscopy. Some of these materials were also characterized by single‐crystal X‐ray analysis. The photophysical properties are studied by UV‐visible and fluorescence spectroscopy.
Unveiling barriers to the integration of blockchain‐based circular economy and Industry 5.0 in manufacturing industries: A strategic prioritization approach
Authors: Kannan Devika , Amiri Alireza Shamekhi , Shaayesteh Mayssam Tarighi , Nasr Arash Khalili , Mina Hassan 
Published: July 2024

AbstractAlthough Industry 4.0 plays the role of a catalyst in the transition from a linear economy to a circular economy (CE), some sustainability goals are neglected by prioritizing machines over humans. Industry 5.0 insists on combining technology with human values to achieve sustainable development goals. Therefore, the integration of CE and Industry 5.0 leads to sustainable synergy in various industries, especially in manufacturing industries. However, their integration is always associated with challenges and barriers. This study identifies a set of these barriers in the electric vehicle battery production industry from the financial, technical, supply chain, cultural, and regulatory and processes perspectives through a deep literature review. The fuzzy weighted influence non‐linear gauge system method is used to analyze the relationship between identified barriers and their prioritization. Finally, we leverage the knowledge of four experts from an electric vehicle battery manufacturing company in Southeast Asia to validate the proposed approach and to rank the barriers. The results demonstrate that immature technology providers are the biggest obstacle in the integration of blockchain‐based CE and Industry 5.0 in the electric vehicle battery manufacturing industry.
Interventional closure of an iatrogenic LAA‐perforation by means of a PFO‐occluder
Authors: Genske Florian , Marquetand Christoph , Schmidt Tobias , Stiermaier Thomas , Eitel Ingo 
Published: July 2024

AbstractAtrial fibrillation (AF) is the most common rhythm disorder with a high risk for cardioembolic strokes. Interventional occlusion of the left atrial appendage (LAA) is an alternative to the widely established stroke prevention with oral anticoagulation. Complications through LAA closure (LAAC) are rare and usually occur periinterventional. We present a case of an 87‐year‐old patient who presents for elective LAAC. After placement of the LAA occluder (Amplatzer Amulet device 25 mm) in the LAA and partial resheathing, the patient developed a pericardial effusion (PE), became hemodynamically unstable and went into cardiac arrest with the need for cardiopulmonary resuscitation (CPR). After drainage of the PE, we closed the causative LAA‐perforation using a persistent foramen ovale (PFO)‐occluder device (Amplatzer Talisman, 25 mm). Thereby we were able to successfully seal the perforation and stabilize the patient. The patient was monitored at our intensive care unit for 2 days and left the hospital in good condition a few days after. Procedural complications during interventional LAAC are rare but can be serious. The most common complication, PE, requires percutaneous drainage and often cardiac surgery. We present a case in which a perforation and following PE with hemodynamic relevance and need for CPR was resolved with an interventional strategy through implantation of a PFO‐occluder into the perforation. With this approach we were able to show that in the right setting even serious complications can be treated by interventional measures, thereby not only saving the patient's life, but also avoiding cardiac surgery.
Manual Microcatheter‐tip Modification: A bailout option for difficult “tip‐in” technique during chronic total occlusion percutaneous coronary intervention
Authors: Novotný Vojtěch , Ungureanu Claudiu , Král Aleš , Varvařovský Ivo 
Published: July 2024

AbstractThe retrograde approach in chronic total occlusion (CTO) interventions often encounters significant challenges, particularly, when aligning the retrograde microcatheter (MC) with the antegrade system is difficult, complicating or even preventing standard externalization. To address these issues, techniques like the “tip‐in” have proven to be effective backup strategies. We introduce the “Manual Microcatheter‐tip Modification” (MMM) technique as an alternative when the “tip‐in” method faces complications. We present a case of a left anterior descending CTO where MMM was successfully employed for the first time, enabling successful revascularization by manually modifying the MC tip to engage the retrograde guidewire. We explore the technical details within the framework of contemporary CTO PCI. This new technique could enhance the management of CTO interventions, offering innovative solutions when traditional externalization methods are problematic.