bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Heterogenized Tungsten Complex: An Efficient and High Yielding Catalyst for the Synthesis of Structurally Diverse Tetra Substituted Pyrrole Derivatives via Four‐Component Assembly.
Authors: Atar Amol B. , Jeong Yeon Tae 
Published: January 2014

AbstractA simple one‐pot protocol for the cyclocondensation of aldehydes, α‐methylene ketones, amines, and nitroalkanes allows the synthesis of tetrasubstituted pyrroles.
ChemInform Abstract: A Convenient Synthesis of 2‐Mercapto‐oxazoles via β‐Ketoazide and Its Application to a Key Intermediate of PI3Kγ Inhibitors.
Authors: Oka Yusuke , Yabuuchi Tetsuya , Sekiguchi Yoshinori 
Published: January 2014

AbstractA modified synthesis of 2‐mercaptooxazoles (III) via an iminophosphorane‐mediated reaction and its application to the multi‐gram preparation of compound (IIIi), a key intermediate for PI3Kγ inhibitors, is reported.
ChemInform Abstract: Cu‐Catalyzed Cross‐Dehydrogenative Coupling Reactions of (Benzo)thiazoles with Cyclic Ethers.
Authors: Xie Zengyang , Cai Yuping , Hu Hongwen , Lin Chen , Jiang Juli , Chen Zhaoxu , Wang Leyong , Pan Yi 
Published: January 2014

AbstractThe novel mild method allows the formation of new C‐C bonds between thiazoles and cyclic ethers.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Highly Enantioselective Synthesis of Substituted Dihydropyranopyrazolones.
Authors: Zhang Han‐Ming , Lv Hui , Ye Song 
Published: January 2014

AbstractTitle compounds (III) and (V) are synthesized via NHC‐catalyzed enantioselective [4 + 2] annulation of α‐chloroaldehydes (II) and pyrazolone‐derived oxodienes (I) and (IV).
ChemInform Abstract: Synthesis and Kinetics of the Cyclization of 3‐(Dialkylaminophenyl)‐2‐(phenylcarbonyl)‐prop‐2‐enenitriles.
Authors: Platonova A. Yu. , Glukhareva T. V. , Zimovets O. A. , El'tsov O. S. , Morzherin Yu. Yu. 
Published: January 2014

AbstractReaction of o‐pyridazinobenzaldehydes (I) with benzoylacetone affords fused tetrahydroquinoline derivatives (IV) in a diastereoselective fashion via intermediate propenenitriles (III).
ChemInform Abstract: A One‐Pot Conversion of ortho‐Alkynyl Benzaldehydes into Indolo[2,1‐a]isoquinolines.
Authors: Kraus George A. , Beasley Jonathan 
Published: January 2014

AbstractTreatment of alkynylbenzaldehydes with aniline ylide (II) results in the formation of indole intermediates.
ChemInform Abstract: Copper(I) Iodide‐Catalyzed Aerobic Oxidative Synthesis of Imidazo[1,2‐a]pyridines from 2‐Aminopyridines and Methyl Ketones.
Authors: Mohan Darapaneni Chandra , Donthiri Ramachandra Reddy , Rao Sadu Nageswara , Adimurthy Subbarayappa 
Published: January 2014

AbstractThe reaction proceeds through C—H activation with oxidative linkage of two C—N bonds under mild conditions and oxygen as a sole oxidant.
ChemInform Abstract: Copper‐Catalyzed Intermolecular Oxidative Cyclization of Haloalkynes: Synthesis of 2‐Halo‐Substituted Imidazo[1,2‐a]pyridines, Imidazo[1,2‐a]pyrazines and Imidazo[1,2‐a]pyrimidines.
Authors: Gao Yang , Yin Meizhou , Wu Wanqing , Huang Huawen , Jiang Huanfeng 
Published: January 2014

AbstractThe products bearing a halogen can be further functionalized using known cross‐coupling procedures.
ChemInform Abstract: 4‐Aminoquinoline‐1,3,5‐triazine: Design, Synthesis, in vitro Antimalarial Activity and Docking Studies.
Authors: Bhat Hans Raj , Singh Udaya Pratap , Gahtori Prashant , Ghosh Surajit Kumar , Gogoi Kabita , Prakash Anil , Singh Ramendra K. 
Published: January 2014

AbstractThe synthesized compounds show considerable activity against chloroquine sensitive and chloroquine resistant strains of P.
ChemInform Abstract: Synthesis of Substituted Benzo[b]selenophenes.
Authors: Arsenyan P. , Paegle E. , Belyakov S. 
Published: January 2014

AbstractMethods for the synthesis of 3‐cyano‐, 3‐tetrazolyl‐, and 3‐acylamino‐ benzoselenophene derivatives as well as a convenient method for the chlorination of benzoselenophenes at the selenium atom are developed.
ChemInform Abstract: N‐(Organylmethylidene)bis(chloromethylidene)thiomorpholin‐4‐amines and ‐selenomorpholin‐4‐amines.
Authors: Martynov A. V. , Makhaeva N. A. , Amosova S. V. 
Published: January 2014

Abstractsynthesis and characterization by NMR and mass spectrometry
ChemInform Abstract: New Phenstatin—Fatty Acid Conjugates: Synthesis and Evaluation.
Authors: Chen Jinhui , Brown David P. , Wang Yi‐Jun , Chen Zhe‐Sheng 
Published: January 2014

Abstract6 Phenstatin or isophenstatin‐containing esters of oleic, linoleic and stearic acid of type (VII) or (VIII) are prepared by a reaction sequence as outlined for (VII).
ChemInform Abstract: [HMIM][Br9]: A Room‐Temperature Ionic Liquid Based on a Polybromide Anion.
Authors: Haller Heike , Hog Michael , Scholz Franziska , Scherer Harald , Krossing Ingo , Riedel Sebastian 
Published: January 2014

Abstract[hmim][Br9] is prepared by addition of Br2 to [hmim]Br in a molar ratio of 5:1 (‐40 °C, 72 h).
Synthesis of Acetonitrile from Ammonium Acetate in Sub‐ and Supercritical Water
Authors: Nguyen Thi Thu Hang , Aras Gökhan , Vogel G. Herbert 
Published: January 2014

AbstractAcetonitril ist ein wichtiges Lösungsmittel und Zwischenprodukt der chemischen Industrie und fällt bisher als Nebenprodukt der Acrylnitrilsynthese an. Um eine industriell unabhängige, nachhaltige Herstellroute auf Basis von nachwachsenden Rohstoffen zu entwickeln, wurde im Rahmen dieser Arbeit ein direkter Syntheseweg, ausgehend von Essigsäure bzw. Ammoniumacetat in nah‐ und überkritischem Wasser, untersucht. Die Experimente erfolgten in einer Hochdruckanlage. Es konnte gezeigt werden, dass Acetonitril nach einem Zweireaktorkonzept, ohne Zusatz eines Katalysators, mit nahezu quantitativer Ausbeute hergestellt werden kann.
Adjuvant radiotherapy and lymph node dissection in pancreatic cancer treated with surgery and chemotherapy
Authors: Mellon Eric A. , Springett Gregory M. , Hoffe Sarah E. , Hodul Pamela , Malafa Mokenge P. , Meredith Kenneth L. , Fulp William J. , Zhao Xiuhua , Shridhar Ravi 
Published: January 2014

BACKGROUNDThe objective of this study was to determine the effects of postoperative radiation therapy (PORT) and lymph node dissection (LND) on survival in patients with pancreatic cancer.METHODSThe 2004 to 2008 Surveillance, Epidemiology, and End Results (SEER) database was analyzed to identify patients with pancreatic cancer who underwent surgery and received chemotherapy and to evaluate the correlation between overall survival (OS), PORT, and LND.RESULTSIn total, 2966 patients were identified who underwent pancreatic resection (1842 PORT, 1124 no PORT). Median survival, 1‐year OS, and 3‐year OS were 21 months, 77%, and 28%, respectively, with PORT versus 20 months, 70%, and 25%, respectively, without PORT (P = .02). Subset analysis revealed that the benefit of PORT was limited to lymph node‐positive (N1) patients. Median survival, 1‐year OS, and 3‐year OS for patients with N1 disease were 19 months, 73%, and 25%, respectively, for those who received PORT versus 18 months, 67%, and 20%, respectively, for those who did not receive PORT (P < .01). An increasing lymph node count was associated with increased survival on multivariate analysis in all patients and in patients with N1 disease (both P < .001). Significant cutoff points for OS based on LND in patients with N1 disease were identified for those who had ≥8, ≥10, ≥12, ≥15, and ≥20 lymph nodes resected. Multivariate analysis for OS revealed that increasing age, T3 and T4 tumors, N1 stage, and moderately and poorly differentiated grade were prognostic for increased mortality, while female gender, PORT, and LND were prognostic for decreased mortality. In patients with N1 disease, other than patient age, all of these factors remained significant. In patients with N0 disease, only T1 and T2 tumor classification and having a tumor that was less than high grade were associated with survival benefit.CONCLUSIONSThis SEER analysis demonstrated an associated survival benefit of PORT and LND in patients with N1, surgically resected pancreatic cancer who received chemotherapy. Cancer 2014;120:1171–1177. © 2013 American Cancer Society.
Synergistic effect of smoking with genetic variants in the AMPKα1 gene on the risk of coronary artery disease in type 2 diabetes
Authors: Ma Xiaowei , Zhang Jianwei , Deng Ruifen , Ding Shan , Gu Nan , Guo Xiaohui 
Published: January 2014

AbstractBackgroundIncreasing evidence suggests that adenosine monophosphate‐activated protein kinase (AMPK) plays a critical physiological role in the cardiovascular system. The objective of this study was to assess the possible correlation between the genetic variability of the AMPKα1 (PRKAA1) gene and the risk of cardiovascular disease, as well as the interactive effects of the genetic variations and environmental factors, on the risk in Chinese patients with type 2 diabetes.MethodsFive haplotype‐tagging single nucleotide polymorphisms (SNPs) at the AMPKα1 locus and 404 unrelated Chinese Han subjects with type 2 diabetes were studied; 260 individuals with coronary artery disease and 144 non‐coronary artery disease controls were genotyped using the polymerase chain reaction–restriction fragment length polymorphism assay.ResultsMinor allele C at rs3805489 was protective from coronary artery disease in type 2 diabetic subjects compared with allele A (OR 0.67, 95% CI 0.48–0.92, p = 0.015). There was no significant correlation between the genotypes at five SNPs and the risk of coronary artery disease. In addition, a significant interaction was identified between smoking status and rs3805489 (p = 0.018 for interaction). The smokers with genotype AA at the SNP had a three‐fold higher risk of coronary artery disease compared with non‐smokers with genotypes AC or CC (OR′ 3.02, 95% CI′ 1.39–6.57, p′ = 0.005, after adjustment for other known coronary artery disease risk factors).ConclusionsThe genetic variability at the AMPKα1 locus has synergetic effects with smoking to increase the risk of coronary artery disease in the Chinese Han population with type 2 diabetes. Copyright © 2014 John Wiley & Sons, Ltd.
Severe retinopathy following radiation therapy with a moderate dose for orbital mucosa‐associated lymphoid tissue lymphoma
Authors: Hata Masaharu , Kaneko Akihiro , Tomita Naoto , Inoue Tomio 
Published: January 2014

AbstractMucosa‐associated lymphoid tissue (MALT) lymphoma is a radiosensitive malignancy. We report on a case of severe retinopathy following radiation therapy with a moderate dose for orbital MALT lymphoma. A 69‐year‐old woman with orbital MALT lymphoma received definitive radiation therapy with a total dose of 36 Gy in 18 fractions. The patient showed complete response but had severe retinopathy along with marked deterioration in visual acuity at 2 years after irradiation. Although the patient underwent treatments for retinopathy, including laser photocoagulation and steroid injection, improvement of the visual acuity was modest. This case developed severe radiation‐induced retinopathy after radiation therapy with the moderate dose of 36 Gy that is considered to be usually safe. Copyright © 2014 John Wiley & Sons, Ltd.
Comparison of a Combined Nontreponemal (VDRL) and Treponemal Immunoblot to Traditional Nontreponemal and Treponemal Assays
Authors: Franken Alicia A. , Oliver Joyce H. , Litwin Christine M. 
Published: January 2014

BackgroundSerology is the mainstay for the diagnosis and management of patients with syphilis. Newer technologies such as immunoblotting are now available for the diagnosis of syphilis.MethodsA commercial IgM/IgG immunoblot assay that detects both nontreponemal (VDRL‐Venereal Disease Research Laboratory) and treponemal antibodies was compared with standard nontreponemal and treponemal assays. The immunoblot and T. pallidum particle agglutination assay (TP‐PA) were performed on 198 samples. Ninety‐seven samples were Rapid plasma reagin (RPR)‐positive and one hundred one were RPR‐negative. Positive RPR samples were titered by VDRL.ResultsThe agreement, sensitivity, and specificity of the IgM/IgG VDRL results of the immunoblot compared to RPR were 74.2% (95% CI: 67.2–80.2), 77.3% (95% CI: 70.2–83.4), and 71.3% (95% CI: 64.4–77.1), respectively. The agreement, sensitivity, and specificity of the IgM/IgG treponemal immunoblot compared to TP‐PA were 100% for all parameters, if the ten equivocal results were not used in the calculation.ConclusionThe treponemal portion of the ViraBlot IgM/IgG immunoblot compared well with the treponemal confirmation assay and could be a useful supplemental method to fluorescent treponemal antibody or TP‐PA for the confirmation of syphilis. The addition of the detection of nontreponemal antibodies to the immunoblot assay, however, may not be of added benefit to the overall assay, due to decreased sensitivity and specificity compared to standard assays.
Immunogenicity of a 2009 pandemic influenza virus A H1N1 vaccine, administered simultaneously with the seasonal influenza vaccine, in children receiving chemotherapy
Authors: Ottóffy Gábor , Horváth Petra , Muth Lajos , Sólyom Alexander , Garami Miklós , Kovács Gábor , Nyári Tibor , Molnár Dénes , Pauler Gábor , Jankovics István 
Published: January 2014

BackgroundNo examination of simultaneous vaccination against pandemic H1N1 and the seasonal influenza virus strains, in children with cancer receiving chemotherapy, are yet published. We investigated the immunogenicity of a whole‐virion, inactivated, adjuvanted pandemic H1N1, and seasonal influenza vaccines administered simultaneously to children with cancer undergoing chemotherapy.ProcedureWe prospectively enrolled 27 pediatric patients receiving therapy for various types of cancer. All received influenza vaccination once in a seasonal risk period. We checked hemaglutination‐inhibition (HAI) antibody titers in the sera of patients before, and 21–28 days after vaccination. Seroprotective titer was defined as an antibody titer ≥40, and seroresponse as ≥4‐fold increase in antibody titers after vaccination.ResultsThe pre‐ and post‐vaccination seroprotective rates were H1N1: 33–48%, H3N2: 56–78%, B: 0–15% for seasonal influenza, and for pandemic H1N1: 15–37%. The seroresponse rates for seasonal influenza H1N1, H3N2, and B were 22%, 37%, and 22%, respectively, and 30% for the pandemic H1N1 vaccine.ConclusionsWhole‐virion, inactivated, adjuvanted vaccine for the pandemic H1N1 Influenza A virus and the seasonal influenza vaccines were found safe and partially immunogenic in children with cancer receiving chemotherapy. The only determinants of responsiveness were lymphocyte count and serum immunoglobulin‐G. Only influenza B vaccine elicited significant differences in differences in pre‐ and post‐vaccination seroprotective rates. The response to vaccination for pandemic H1N1 is as effective as other vaccines, however administration of a single vaccine during chemotherapy is more comfortable for pediatric cancer patients. Pediatr Blood Cancer 2014;61:1013–1016. © 2014 Wiley Periodicals, Inc.
Mikrowelt im Lichtgriff
Authors: Alpmann Christina , Kruse Annika , Denz Cornelia 
Published: January 2014

AbstractOptische Pinzetten manipulieren transparente Mikro‐ und Nanopartikel mit Laserlicht. Die beiden grundlegenden Kräfte, die dies bewirken, sind die Streukraft sowie die Gradientenkraft durch inhomogene Lichtfelder. Diese Kräfte formen optische Fallen, die Partikel zerstörungsfrei fangen und bewegen. Es gibt zahlreiche unterschiedliche Bauformen, die abhängig von der Aufgabenstellung eingesetzt werden. Besonders flexibel ist die holographisch optische Pinzette. Bei ihr werden die Fallen durch Hologramme auf einem Flüssigkristalldisplay computergesteuert. Das erlaubt Hunderte von verschiedenen Fallen in der Probe, die einzeln ansteuerbar sind. Derzeit wird an Pinzetten mit noch komplexeren Lichtfeldern geforscht. Die optische Mikromanipulation ermöglicht zahlreiche Anwendungen, zum Beispiel in der Untersuchung lebender Zellen oder in der Organisation von Materie auf der Nanoskala.
Ancestral mutations as a tool for solubilizing proteins: The case of a hydrophobic phosphate‐binding protein
Authors: Gonzalez Daniel , Hiblot Julien , Darbinian Nune , Miller Jernelle C. , Gotthard Guillaume , Amini Shohreh , Chabriere Eric , Elias Mikael 
Published: January 2014

Stable and soluble proteins are ideal candidates for functional and structural studies. Unfortunately, some proteins or enzymes can be difficult to isolate, being sometimes poorly expressed in heterologous systems, insoluble and/or unstable. Numerous methods have been developed to address these issues, from the screening of various expression systems to the modification of the target protein itself. Here we use a hydrophobic, aggregation‐prone, phosphate‐binding protein (HPBP) as a case study. We describe a simple and fast method that selectively uses ancestral mutations to generate a soluble, stable and functional variant of the target protein, here named sHPBP. This variant is highly expressed in Escherichia coli, is easily purified and its structure was solved at much higher resolution than its wild‐type progenitor (1.3 versus 1.9 Å, respectively).
Regionale Koordination in der Psychiatrie
Authors: Elgeti Hermann 
Published: January 2014

EinleitungUnsere seelische Gesundheit ist ein ebenso kostbares wie verletzliches Gut, sie steht in engen Wechselbeziehungen zu körperlichem Wohlbefinden und sozialer Lage. Psychische Erkrankungen sind häufig und vielgestaltig, neigen zur Chronifizierung und benötigen individuell passgenaue Hilfen. Das psychiatrisch-psychotherapeutische Hilfesystem ist weithin zersplittert und lückenhaft, seine wirksame regionale Koordination immer wieder gefordert und doch bisher nur hier und da in Ansätzen verwirklicht.
,,Verrückt? Na und!‘‘ - Ein Projekt von Irrsinnig Menschlich
Authors: Göller Norbert 
Published: January 2014

Einleitung
Das Projekt „Verrückt? Na und!“ lädt junge Menschen ab 14 Jahre und ihre Lehrkräfte zum offenen Austausch über die großen und kleinen Fragen der seelischen Gesundheit ein. Das Projekt hilft, psychischen Krisen vorzubeugen und macht Jugendlichen und jungen Erwachsenen Mut, aufeinander zuzugehen und offener miteinander zu reden – auch über schwierige und ernste Themen. Bis 2020 soll in fast jedem Kreis in Deutschland eine Regionalgruppe entstehen, die Projekt in Schulen und anderen Einrichtungen anbieten.
COPSOQ International Network: Co-operation for research and assessment of psychosocial factors at work
Authors: Nübling Matthias , Burr Hermann , Moncada Salvador , Kristensen Tage S. 
Published: January 2014

Abstract
COPSOQ is a comprehensive questionnaire on psychosocial factors at work which is internationally widely used since approx. 10 years for risk assessments in organisations. The International COPSOQ-Network was established in 2009 by scientific and empirical users of the COPSOQ. Main aim is the international scientific exchange concerning the use of COPSOQ. A second goal lies in the coordination of research and further development of the questionnaire (content and measurement qualities), to facilitate international comparison studies. Further information: www.copsoq-network.org
Traumatic Injury Patterns Associated With Static Line Parachuting
Authors: Ball Vincent L. , Sutton Jared A. , Hull Aicha , Sinnott Bridget A. 
Published: January 2014

Objective We investigated the incidence and injury patterns of acute parachuting injuries evaluated at a level II military facility during a 5-year period to compile medical information that may assist in improving the safety of parachuting. Methods A retrospective chart review of all parachuting injuries that presented to the Madigan Army Medical Center emergency department in Tacoma, Washington, during a 5-year period from February 2005 to June 2011. Results A total 110 patient charts met inclusion criteria. Lower extremity injuries made up 65% of total injuries, followed by 22% head injuries, 22% neck or back injuries, and 19% upper extremity injuries. One patient died in the emergency department of head injuries, and 1 patient was transferred for an open-book pelvic fracture. The most common phase of the jump in which to sustain injury was at landing. A total of 15 patients were admitted to the hospital. It is of note that some patients had combined injuries. The mechanism of injury documented in 96 of 110 (87%) patients and 10 of 15 (66%) admitted patients was a difficult landing. Conclusions The rate of injury for each area of the body is within previously reported rates, with lower extremity injuries making up the largest category and leading to the majority of admissions. The most common time to sustain an injury was during landing, which represented a majority of both emergency room visits and hospitalizations.
Social networks and labor market inequality between ethnicities and races
Authors: TOOMET OTT , VAN DER LEIJ MARCO , ROLFE MEREDITH 
Published: January 2014

AbstractThis paper analyzes the relationship between unexplained racial/ethnic wage differentials on the one hand and social network segregation, as measured by inbreeding homophily, on the other. Our analysis is based on both the US and Estonian surveys, supplemented with the Estonian telephone communication data. In the case of Estonia we consider the regional variation in economic performance of the Russian minority, and in the US case we consider the regional variation in black--white differentials. Our analysis finds a strong relationship between the size of the wage differential and network segregation: Regions with more segregated social networks exhibit larger unexplained wage gaps.
On two new K2FeF5 forms
Authors: Le Bail Armel 
Published: January 2014

Two additional forms of K2FeF5 are disclosed and characterized by powder diffraction. One (form-IV) adopts a new A2MF5 structural type, space group C2/m, a = 13.0919(2) Å, b = 5.7311(1) Å, c = 7.3114(1) Å, β = 118.241(1), and Z = 4, it is obtained from the thermal evolution of form-III, isostructural with Rb2FeF5, space group Pnma, a = 7.3964(2) Å, b = 5.6779(1) Å, c = 11.5445(3) Å, and Z = 4. Both forms are compared to two previously reported polymorphs. The III → IV transition is topotactic, conserving the same zigzag cis-connected octahedral (FeF5)n2n− chains after an ~90° rotation and 1/2b translation of half of them.
Three new structural forms of thiocolchicoside, a muscle relaxant, as shown by X-ray powder diffraction
Authors: Toro R. , Contreras J. , Díaz de Delgado G. , Delgado J. M. , Pinto J.L. , Henao J.A. 
Published: January 2014

Thiocolchicoside (THC) is an important active pharmaceutical ingredient (API) used as a muscle relaxant because of its anti-inflammatory and analgesic effects. The only entry for a THC-related compound present in the Cambridge Structural Database (CSD) corresponds to a THC ethanol solvate hydrate (refcode: THCLCS). The diffraction pattern recorded for the THC raw material (C27H33NO10S·xH2O) is different from the pattern calculated using the THCLCS crystallographic data contained in the CSD. The indexing of the THC raw material pattern, produced an orthorhombic unit cell with a = 28.018(7) Å, b = 12.519(2) Å, c = 8.519(1) Å, and V = 2988.01 Å3. All the diffraction maxima of the powder pattern of a phase recrystallized in water (C27H33NO10S·2H2O) can be indexed in an orthorhombic cell with a = 25.264(4) Å, b = 13.537(3) Å, c = 8.553(1) Å, and V = 2925.12 Å3. Thermogravimetric analysis shows that this compound is a dihydrate phase. Upon heating, a new anhydrous phase (C27H33NO10S) with a monoclinic cell and unit cell parameters: a = 17.090(5) Å, b = 19.485(5) Å, c = 8.526(3) Å, β = 100.30(2)°, and V = 2793.34 Å3 is obtained.