bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mnemonic brain state engagement is diminished in healthy aging
Authors: Moore Isabelle L. , Smith Devyn E. , Long Nicole M. 
Published: August 2024

AbstractHealthy older adults typically show impaired episodic memory – memory for when and where an event oc-curred – but intact semantic memory – knowledge for general information and facts. As older adults also have difficulty inhibiting the retrieval of prior knowledge from memory, their selective decline in episodic memory may be due to a tendency to over engage the retrieval state, a brain state in which attention is focused internally in an attempt to access prior knowledge. The retrieval state trades off with the encoding state, a brain state which supports the formation of new memories. Therefore, episodic memory declines in older adults may be the result of differential engagement in mnemonic brain states. Our hypothesis is that older adults are biased toward a retrieval state. We recorded scalp electroencephalography while young, middle-aged and older adults performed a memory task in which they were explicitly directed to either encode the currently presented object stimulus or retrieve a previously presented, categorically-related object stimulus. We used multivariate pattern analysis of spectral activity to decode engagement in the retrieval vs. encoding state. We find that all three age groups can follow top-down instructions to selectively engage in encoding or retrieval and that we can decode mnemonic states for all age groups. However, we find that mnemonic brain state engagement is diminished for older adults relative to middle-aged adults. Our interpretation is that a combination of executive control deficits and a modest bias to retrieve modulates older adults’ mnemonic state engagement. Together, these findings suggest that dif-ferential mnemonic state engagement may underlie age-related memory changes.
Exploring Transcriptional Regulation of Soybean Tissue Development with Machine Learning Method
Authors: Yang Yong 
Published: August 2024

AbstractSoybean is one of the most important crops that is widely demanded by people in daily lives. Measuring the transcriptome of a tissue or condition is a powerful way to detect changes in genetic adaptation. However, it remains difficult to identify the key genes in transcriptional regulation most likely to explain specific traits. Here, we outline a machine learning method that utilizes publicly available soybean RNA-seq data by uncovering conserved expression patterns of genes controlled by transcription factor (TF) / transcription regulator (TR) genes in soybean tissues across time and space under various conditions. In addition to its function in gene expression homeostasis, we can also identify important TF/TR genes related to soybean leaf, stem and root tissue development. Combining with co-expression modules highly expression in the tissue, we also highlight the impact of candidate TF/TR genes in the module in different tissues that may shape the dynamics of soybean development. Together, our results revealed the importance of transcriptional regulatory module analysis in unraveling key traits in the soybean development, in particular those TFs/TRs and their target genes.
DNA polymerase Lambda is anchored within the NHEJ synaptic complex via Ku70/80
Authors: Frit Philippe , Amin Himani , Zahid Sayma , Barboule Nadia , Hall Chloe , Matharu Gurdip , Hardwick Steven W. , Chauvat Jeanne , Britton Sébastien , Chirgadze Dima Y. , Ropars Virginie , Charbonnier Jean-Baptiste , Calsou Patrick , Chaplin Amanda K. 
Published: August 2024

AbstractNon-homologous end joining (NHEJ) is the predominant pathway by which double-strand DNA breaks (DSBs) are repaired in mammals. To enable final break closure, various NHEJ end-processing factors respond to the chemistry of the damaged DNA ends. Amongst these factors is DNA polymerase lambda (Pol λ), a member of the Pol X family. How members of the Pol X family engage with the NHEJ complex is unknown. Here, we present cryo-EM structures of Pol λ in complex with the Ku70/80 DSB sensor whilst engaged with the DNA-PK holoenzyme in a long-range synaptic complex. These structures reveal a specific interaction site between Ku70/80 and the Pol λ BRCT domain. The functionality of this interaction is assessed by generating point mutations on either side of the Pol λ BRCT:Ku70/80 interface. Using these mutants in two orthogonal assays in cells (live protein recruitment at biphoton laser-damaged nuclear sites and transfection with an original gap-filling reporter plasmid) defines the molecular basis and essentiality of the BRCT domain for the recruitment and activity of the Pol λ within the NHEJ complex. Ultimately, these data explain the role of this interaction in cell survival to DSBs. Finally, we propose a unified model for the interaction of the three Pol X family members bearing BRCT domains with the same site of Ku70/80.
Golgi compaction facilitates microtubule nucleation to drive adult vertebrate peripheral neuron regeneration
Authors: Mortimer Alice E , Reid Adam J , Das Raman M 
Published: August 2024

AbstractPeripheral neurons regenerate in response to injury, but their cell intrinsic processes are poorly understood and seldom sufficient to effect clinical restoration. Using a novel assay for high-resolution live imaging of regenerating adult vertebrate neurons, we identify acute fragmentation and rapid recompaction of the somatic Golgi as a key driver of peripheral neuron regeneration, implicating this organelle as a therapeutic target in an area of clinical unmet need. Compaction of the fragmented Golgi facilitates stepwise recruitment of the microtubule nucleation factors AKAP9 and γ-tubulin within a discrete period that corresponds with acentrosomal Golgi-mediated microtubule nucleation. Furthermore, disruption of AKAP9 or γ-tubulin recruitment compromises microtubule nucleation leading to impaired regeneration. Crucially, these mechanisms are conserved in the contexts ofin vivorat sciatic nerve transection and in primary human peripheral neurons. This work transforms our understanding of the cell intrinsic mechanisms that render injured peripheral neurons competent to initiate axon regeneration.
“Superiority of Rhythmic Auditory Signals over Electrical Stimulation to Entrain Behavior”
Authors: Cabral-Calderin Yuranny , Henry Molly J. 
Published: August 2024

AbstractNeural tracking (entrainment) of auditory rhythms enhances perception. We previously demonstrated that transcranial alternating current stimulation (tACS) can enhance or suppress entrainment to rhythmic auditory stimuli, depending on the timing between the electrical and auditory signals, although tACS effects are primarily modulatory. This study further investigated entrainment to tACS and auditory rhythms when the electrical and auditory signals were presented together (Experiment 1, N = 34) or independently (Experiment 2, N = 24; Experiment 3, N = 12). We hypothesized that tACS effects would be more pronounced when the auditory rhythm was made less perceptually salient to reduce the competition with the electrical rhythm. Participants detected silent gaps in modulated or unmodulated noise stimuli. In Experiment 1, auditory stimuli predominated in entraining behavior. While behavioral entrainment to sound rhythms was affected by the modulation depth of the auditory stimulus, entrainment to tACS was not. In Experiment 2, with no rhythmic information from the sound, 16 of 24 participants showed significant behavioral entrainment to tACS, although the most effective tACS frequency varied across participants. An oscillator model with a free parameter for the individual resonance frequency produced profiles similar to those we observed behaviorally. In Experiment 3, both neural and behavioral entrainment to rhythmic sounds were affected by the auditory stimulus frequency, but again the most effective entraining frequency varied across participants. Our findings suggest that tACS effects depend on the individual’s preferred frequency when there is no competition with sensory stimuli, emphasizing the importance of targeting individual frequencies in tACS experiments. When both sensory and electrical stimuli are rhythmic and compete, sensory stimuli prevail, indicating the superiority of sensory stimulation in modulating behavior.
The mediating role of risk management in the relationship between audit committee effectiveness and firm sustainability performance
Authors: Mahsina Mahsina , Agustia Dian , Nasution Damai , Dianawati Wiwiek 
Published: August 2024

Purpose
This study aims to investigate the direct relationship between audit committee effectiveness and sustainability performance and the mediating role of risk management in the relationship between audit committee effectiveness and firm sustainability performance.

Design/methodology/approach
The Hayes Process regression mediation model was used in this study. The data included 2,590 firm-year observations from 518 publicly non-banking and finance companies on the Indonesia Stock Exchange from 2017 to 2021.

Findings
This study proves the important role of risk management in mediating the effect of audit committee effectiveness on firm sustainability performance. Audit committee effectiveness was found to positively and significantly affect risk management. However, the effect of audit committee effectiveness on firm sustainability performance was statistically insignificant. The robustness checks and additional tests support all the main regression results.

Research limitations/implications
Sample firms from Indonesia were used as representatives of developing countries. Further research may use more sample firms from multiple countries or provide a comparative study between firms in different countries.

Practical implications
The authority must enhance the audit committee’s role in risk management quality due to the indirect effect between the audit committee and sustainability disclosure. It should also expand the audit committee’s role to include sustainability disclosure.

Social implications
This study could increase community awareness of firm sustainability. Where a company is required to provide more eco-products, stakeholders are, therefore, expected to have more equal concerns.

Originality/value
To the best of the authors’ knowledge, this study is the first to examine risk management as a mediator of the effect of audit committee effectiveness on firm sustainability performance.
Community intervention delivered by frontline healthcare professionals to promote eating self-efficacy
Authors: Levesque Annabel , Roy-Wsiaki Genevieve N. 
Published: August 2024

PurposeThe goal of this study was to assess changes in eating self-efficacy after participating in a brief psychoeducational group intervention, grounded in the cognitive-behavioral model, delivered by dieticians in community-based health facilities.Design/methodology/approachThe study was conducted using a quasi-experimental, pre-post design. A total of 110 program participants took part in the study. They were asked to complete the Eating Self-Efficacy Scale before the start of the intervention, at the end of the intervention, and three months after the intervention ended. Data were analyzed using the Linear Mixed Model.FindingsParticipants’ personal sense of control over their eating behaviors significantly increased after they completed the program and continued to increase up to the three-month follow-up. The effect of the intervention remained significant after controlling for differences in age and whether participants had access to other forms of individual support or completed the follow-up during the COVID-19 general lockdown.Practical implicationsBy promoting participants’ sense of eating self-efficacy, this intervention could lead to positive dietary changes, which in turn could promote better health and healthy aging.Social implicationsThis community intervention is readily accessible and represents a cost-effective approach to promote healthy eating, reducing the risk of chronic disease and the need for medical care, thereby cutting costs for the healthcare system.Originality/value(1) This study addresses a gap in the scientific literature as there was limited published research to date that investigated this intervention. (2) The three-month follow-up made it possible to evaluate whether changes in eating self-efficacy were maintained over time. (3) Potential confounding variables, including age, having access to other forms of individual support and the COVID-19 general lockdown, were taken into account.
The historical origins of earnings management: a geographical discontinuity design based on the Great Wall
Authors: Gao Ming , Gu Qiankun , He Shijun , Kong Dongmin 
Published: August 2024

PurposeDoes the history of the bureaucratic system, along with the establishment of the Great Wall during the Ming and Qing dynasties (1368–1911), affect firm behavior across the borderlands of the Great Wall?Design/methodology/approachThe Ming and Qing dynasties built a centralized administrative system in the borderlands on the south side of the Great Wall, in contrast to the “feudal lordship” system on the north side. Employing a regression discontinuity analysis framework with the Great Wall as a geographical discontinuity, we examine the long-run effects of the Great Wall on firms’ earnings management.FindingsUsing a large sample of nonlisted firms in the central core frontier region, we show that the earnings management of firms in the region south of the Great Wall is significantly curtailed compared with firms in the north of it, and this effect is more pronounced for non-SOEs. Our findings are robust to a battery of tests to account for alternative explanations.Practical implicationsOverall, by emphasizing the role of institutions, like legal system, shaped in history on firms’ earnings management, this study sheds new light on institutional determinants of firms’ behaviors in earnings information disclosure.Originality/valueFirst, we enrich our understanding of the institutional determinants of firms’ financial reporting outcomes. Second, our findings shed new light on the long-term effects of historical ruling styles on modern corporate behavior.
Exploring intrinsic and extrinsic sources of academic well-being among university teachers through Q methodology research
Authors: Chaaban Youmen , Qadhi Saba , Du Xiangyun 
Published: August 2024

PurposeThis paper investigated the intrinsic and extrinsic sources of academic well-being among university teachers at one university in Qatar, to understand how different factors influence their well-being within academia.Design/methodology/approachDrawing on systems theory, this study employs Q methodology research. Data were collected and analyzed using 35 statements (Q-items) related to academic well-being. Twenty-one university teachers participated in the study, providing a range of perspectives on the factors that influenced their academic well-being.FindingsThe analysis revealed two distinct perspectives among the participants concerning the sources of academic well-being. Factor 1 (F-1) emphasized workplace conditions as the primary source of well-being, whereas Factor 2 (F-2) highlighted individual conditions. Additionally, a significant portion of participants did not align strongly with either factor, indicating diverse and individualized sources of well-being that suggest a complex interplay of various elements affecting academic well-being.Research limitations/implicationsThe study’s sample size is limited to twenty-one university teachers at a single institution, which may affect the generalizability of the findings. Future research should consider a larger, more diverse sample to explore the universality of the findings across different academic contexts.Practical implicationsThe implications for university teachers, researchers, leaders and policymakers include a better understanding of the sources that contribute to academic well-being and the need for adopting systems thinking in addressing these sources.Originality/valueThis study employs a unique application of Q methodology within a systems theory framework to explore the sources of academic well-being among university teachers. Unlike previous research that has primarily focused on anxiety, stress and burnout, this study provides a holistic perspective by capturing the complex interplay between organizational structures and individual identities.
Beating around the bush over knowledge sabotage: the fatal flaw in increasing digital innovation ecosystem performance through innovation capability under technological turbulence
Authors: Arias-Pérez José , Santos Carlos Alberto Frantz dos , Velez-Ocampo Juan , Zen Aurora Carneiro 
Published: August 2024

PurposeThe objective of this article is to analyze the mediating role of innovation capability—both radical and incremental—between technological turbulence and digital innovation ecosystem performance, considering the impact of cross-organizational knowledge sabotage. Despite the enthusiasm surrounding digitization, the high failure rate (80%) of digital transformation projects has received limited attention. This alarming statistic indicates a potential rise in opportunistic behaviors within organizations. We hypothesize that employees seeking to reduce the risk of being displaced by digital technologies, may not only hide knowledge, as previously observed, but also engage in knowledge sabotage by disseminating inaccurate information during the co-creation of digital innovations within the digital innovation ecosystem.Design/methodology/approachThe study employed structural equation modeling to examine moderated mediation using survey data collected from 148 firms, mainly from sectors of high to medium levels of digital intensity.FindingsThe most significant finding indicates that cross-organizational knowledge sabotage considerably reduces the only mediating effect, namely that of incremental innovation capability.Originality/valueOur study presents a novel perspective by investigating the phenomenon of cross-organizational knowledge sabotage. Unlike prior research, which primarily identified the existence of knowledge hiding, our findings suggest that employees are not only willing to withhold information but also to disseminate inaccurate information to external partners. Consequently, our research extends the boundaries of the existing knowledge field by demonstrating that cross-organizational knowledge sabotage has repercussions that extend beyond intra-organizational impacts, as previously recognized. It also adversely affects the outcomes of collaborative work within the digital innovation ecosystem.
Delayed retirement, pension insurance and income inequality
Authors: Zhang Qingjie , Cao Xinbang 
Published: August 2024

PurposeTo investigate the potential of raising the retirement age and reforming pension insurance in mitigating intra- and inter-generational income inequality, thereby offering empirical support for governmental policy formulation.Design/methodology/approachA dynamic general equilibrium model with intertemporal iteration is developed to comprehensively assess the impact of policies raising the retirement age on income inequality, taking into account delayed retirement, survival probability, and pension insurance. The theoretical hypotheses are validated through simulation using MATLAB.FindingsThrough theoretical analysis, it is determined that, given certain assumptions are satisfied, raising the retirement age can effectively mitigate intra-generational income inequality, inter-generational income inequality under both the pay-as-you-go and fund accumulation systems. Simulation results indicate that, under current parameter settings, raising the retirement age can reduce the Gini coefficient. Furthermore, this study reveals that regardless of the pay-as-you-go or fund accumulation system, pension insurance serves as a mechanism for income redistribution and alleviating income inequality.Originality/valueIt offers a theoretical foundation for the government's policy on delayed retirement and endowment insurance.
Probation fear in new starters: understanding and alleviating concerns
Authors: Carnegie Pia 
Published: August 2024

Purpose
This “viewpoint” paper aims to explore the root causes of probation fear, including worries about job security, performance expectations, cultural fit and feedback. It seeks to examine the impact of these fears on employees’ mental health, job performance, work relationships and career progression, as well as the broader implications for employers, such as increased turnover and training costs. Leadership’s role in creating a supportive environment and encouraging feedback is emphasised.

Design/methodology/approach
This paper uses a combination of author observations and literature to explore the intricacies of probation fears faced by employees during the probation process.

Findings
Author observations and literature show that the impact of probation fear is not strictly limited to the employee who is going through the probation process. It is suggested that by addressing probation fear, a more inclusive, supportive and productive workplace can be created. In a collective effort, Employers can implement transparent communication, structured onboarding, supportive feedback, mentorship programs and foster psychological safety and employees can seek clarity, build relationships, prioritise self-care, focus on learning and engage in professional development.

Research limitations/implications
As this paper includes observations from the author the paper could suffer from the writer’s biases even though this is unintended.

Originality/value
To the best of the authors’ knowledge, as this paper includes observations by the author, this study is original. This paper also provides value to both HR and front-line managers involved in the employee probation journey where the exploration of probation fear is under-researched.