bluuebunny/crossref_metadata_2025_split huggingface dataset:
Oppositional Defiant Disorder, Internet Gaming disorder, and Suicidal Ideation among Saudi Adolescents: A Moderated Mediation Model of Gender and Self-Control
Authors: Keshky Mogeda El 
Published: August 2024

Abstract

Background
Adolescence is characterized by behaviors as well as, in some, internet gaming disorders, that may lead to suicidal ideation. Prior research has documented the relationships between oppositional defiant disorder and internet gaming addiction with suicidal ideation among adolescents, but none has studied the potential mediating role of self-control nor the moderation role of gender.
Objective
This study investigated the relationships between oppositional defiant disorder, internet gaming disorder, and suicidal ideation, and applied a moderated mediation model including the roles of gender and self-control.
Method
273 adolescents (mean age = 15.47, 57% females) participated in this study. Respondents completed the Suicidal Ideation Scale, the Internet Gaming Disorder Scale, Short Form, the Oppositional Defiant Scale, and the Self-Control Scale, as well as a set of socio-demographic questions. A moderated mediation model was applied using the PROCESS software package.
Results
As expected, oppositional defiant disorder and internet addiction were positively related with suicidal ideation. Self-control was found to mediate these relationships. Further, it was found that these relationships were stronger in females compared to males.
Conclusions
Efforts to reduce suicidal ideation among adolescents with defiant behaviors and gaming disorder should be directed at enhancing their self-control and should be gender mindful.
Rapid and High-Resolution 3D Printing via Photoacid Genera-tor induced Cationic RAFT Polymerization
Authors: Zhu Jian , Zhao wen , Li Jiajia , Yang Chongyang , Pan Xiangqiang , Zhang Zhengbiao 
Published: August 2024

Abstract

Vinyl ethers, while being typical monomers for living cationic polymerization, have limited commercial use due to poor mechanical properties of their polymers at room temperature. We explored the use of photoacid generators (PAGs) to induce cationic reversible addition-fragmentation chain transfer (RAFT) polymerization for the rapid high-resolution 3D printing of various vinyl ethers. The process demonstrated controlled molecular weights and narrow molecular weight distributions (MWD), with monomer conversions exceeding 90% in minutes. Incorporating a crosslinker enabled 3D printing at speeds up to 8.46 cm h-1 with layer thicknesses as thin as 50 microns. The mechanical properties of the printed objects were tunable by adjusting resin components, allowing for a range of material characteristics from brittle to elastomeric (tensile strength ranging from 13.9 to 31.7 MPa, Young's modulus ranging from 185.6 to 992.7 MPa and elongation at break ranging from 2.8 to 68.3%). Moreover, polymer welding facilitated the creation of gradient materials, showcasing the potential for engineered applications of poly(vinyl ethers).
Prevalence of hip pain in elite badminton players
Authors: Denis Samantha , Rose Camille , Ramos-Pascual Sonia , Garrec Sebastien Le , Rooij Floris Van , Saffarini Mo , Nogier Alexis 
Published: August 2024

Abstract

Background
A number of studies have investigated injuries in badminton players, but none have focused on investigating hip pathologies in this population. Therefore, the purpose of the present study is to (i) report the prevalence of hip pain in elite badminton players currently registered at a national sports institute, (ii) describe their hip pathologies, and (iii) evaluate expectations regarding hip pain before and after becoming elite athletes.
Methods
All badminton players at a national sports institute on 01/09/2023 were contacted by the medical team to complete a questionnaire comprising training information, prevalence of hip pain, and expectations regarding hip pain. The medical database was reviewed to identify all hip pathologies recorded.
Results
Of the 20 elite badminton players registered at the national sports institute (10 females and 10 males, aged 23.8 ± 3.9 years), 9 (45%) reported experiencing hip pain while registered at the institute, 4 at their dominant side only and 5 bilaterally. Six players had cam-type femoroacetabular impingement (FAI), concomitant with coxofemoral chondropathy and/or muscle tears in 3 athletes (requiring femoroplasty in 3). Furthermore, 3 more players had coxofemoral chondropathy and/or muscle tears. Before playing badminton at a high-level, 12 (60%) thought that becoming elite players could cause joint pain; however, none (0%) thought that it would cause pain specifically at their hip joint.
Conclusions
Nine of 20 elite badminton players have experienced hip pain while registered at a national sports institute, with the most common hip pathologies being cam-type FAI (n = 6; 30%) and muscle tears (n = 4; 20%). Although before playing badminton at a high-level, none of the athletes thought that becoming an elite badminton player could cause pain specifically at the hip joint, at the time of the questionnaire, 19 athletes (95%) thought this was common. These findings could allow coaches and medical staff to align expectations regarding the likelihood of hip pain and hip pathologies in badminton players training at an elite level.
WITHDRAWN: Techniques for Building Internal Target Volumes (ITV) in CT Imaging Through Calibration, Artifact Management, Image Registration, and 4DCT Incorporating Motion-Encompassing Methods
Authors: Solomon Girma Biniyam , Kide Kinfe Gebremedhin , Cavedon Carlo 
Published: August 2024

Abstract

This study aimed to enhance the accuracy and efficiency of ITV construction in CT imaging. It utilized a combination of calibration techniques to ensure precise imaging measurements, artifact management strategies to reduce image distortion, advanced image registration methods for spatial alignment, and 4DCT technology to capture dynamic motion information. By incorporating motion-encompassing methods into the process, the study sought to improve the delineation of internal target volumes for more effective treatment planning and delivery in medical settings. Through a systematic evaluation of the proposed techniques, this study work generated promising results in optimizing ITV construction in CT imaging. The findings highlighted the impact of calibration, artifact management, image registration, and 4DCT integration on enhancing the quality and accuracy of internal target volume delineation. The study demonstrated the potential benefits of utilizing motion-encompassing methods to account for patient motion during imaging procedures, leading to more precise and reliable ITV generation for radiation therapy and other medical applications. Overall, the study shed light on the importance of incorporating advanced techniques in CT imaging for building internal target volumes. By addressing key challenges such as motion artifacts and inaccuracies in volume delineation, the study provided valuable insights into improving the quality of medical imaging processes. The results underscored the potential of motion-encompassing methods to revolutionize ITV construction practices, paving the way for enhanced treatment planning and delivery strategies in the field of medical physics and radiation oncology.
Small Fiber Neuropathy in Patients with Dry Eye Disease
Authors: Zidan Asmaa A . , Dean Jordan , Lin Zhirong , Kheirkhah Ahmad , Oaklander Anne Louise , Dana Reza , You Jae Young , Yin Jia 
Published: August 2024

Abstract

Purpose: Small-fiber neuropathy (SFN) refers to a range of peripheral neuropathic conditions affecting small-caliber sensory and/or autonomic nerve fibers. This study aims to determine the prevalence and characteristics of SFN symptoms in patients with dry eye disease (DED).
Design: Cross-sectional study at two academic eye centers
Methods: 31 patients with DED and an Ocular Surface Disease Index (OSDI) greater than 13 were included. SFN symptoms were determined using the Small-Fiber Symptom Survey (SSS), a validated questionnaire, and positive symptoms were defined as having a score of 15.7 or higher (two standard deviations from the mean of healthy individuals without SFN). DED symptoms and ocular pain were assessed using the OSDI and the Ocular Pain Assessment Survey (OPAS), respectively. DED signs were assessed clinically and patient response to standard DED treatment was evaluated 6-12 months after the administration of the questionnaires.
Results: The prevalence of SFN symptoms among DED patients was 77.4%. Positive correlations were found between SSS and OSDI (r=0.43, p=0.017), and between SSS and OPAS (r=0.62, p=0.0003). A negative correlation was observed between SFN symptoms and corneal fluorescein staining (CFS, r=-0.42, p=0.018) but not with tear break-up time or Schirmer’s test results. Despite more intense topical treatment and stable clinical signs of DED, patients with severe SFN symptoms (high SSS scores) had a less favorable subjective response to DED treatment, compared to those with low and moderate SSS scores.
Conclusion: There is a high prevalence of SFN symptoms in patients with DED. SFN symptoms are strongly associated with ocular pain and DED symptoms and are negatively correlated with CFS. Patients with severe SFN symptoms have a less favorable subjective response to standard DED treatment, suggesting the presence of neuropathic conditions that warrant further neurological assessment.
Recent Advances in the Diagnosis, Treatment, and Management of Multiple Sclerosis: A Systematic Review (2017-2024)
Authors: Alhamood Mohammed 
Published: August 2024

Abstract

Objective: This systematic review aims to deliver a comprehensive and critical analysis of the recent advancements in the diagnosis, treatment, and management of Multiple Sclerosis (MS) from 2017 to 2024. The study seeks to identify existing research gaps and provide evidence-based recommendations to guide future research and improve clinical practices.
Methods: An exhaustive literature search was conducted across premier medical databases, including PubMed, Embase, and the Cochrane Library, focusing on studies published between January 2017 and August 2024. The selection process was governed by stringent inclusion and exclusion criteria to ensure the relevance and quality of the studies. A total of 90 studies were included in the final analysis, which were rigorously assessed using the Cochrane Risk of Bias Tool to maintain high methodological standards.
Results: The review identified significant advancements in diagnostic technologies, particularly with the integration of PET-MRI and the application of Artificial Intelligence (AI) in medical imaging, leading to a 40% increase in diagnostic accuracy. In terms of treatment, immunotherapies such as Ocrelizumab and Ofatumumab have shown substantial efficacy, with Ocrelizumab reducing relapse rates by up to 70%. Non-pharmacological interventions, including Cognitive Behavioral Therapy (CBT) and customized exercise programs, were found to significantly improve patients' psychological well-being and physical function.
Conclusions: This review underscores the importance of a multidisciplinary approach to MS management, highlighting the critical role of advanced diagnostic tools, personalized immunotherapies, and non-pharmacological interventions in improving patient outcomes. Future research should focus on developing cost-effective diagnostic strategies, enhancing personalized treatment protocols, and exploring preventive measures to further advance clinical outcomes. The findings emphasize the need for ongoing interdisciplinary collaboration and the continuous professional development of healthcare providers to keep pace with the rapid advancements in MS management.
­­­­Single-Dose Psilocybin Therapy for Alcohol Use Disorder: Pharmacokinetics, Feasibility, Safety, and Efficacy in an Open-Label Study
Authors: Jensen Mathias Ebbesen , Stenbæk Dea Siggaard , Messell Catharina Dragsted , Poulsen Emil Deleuran , Varga Tibor V , Fisher Patrick McDonald , Nielsen Marie Katrine Klose , Johansen Sys Stybe , Volkow Nora D , Knudsen Gitte Moos , Fink-Jensen Anders 
Published: August 2024

Abstract

Background Psilocybin, a serotonin 2A receptor agonist with psychedelic properties, shows promise as a novel treatment for alcohol use disorder (AUD). While current studies involve two dosing sessions, the effects a single dose have not been investigated.
Aims To investigate the pharmacokinetics, feasibility, safety, and efficacy of single-dose psilocybin therapy in AUD.
Methods This open-label, single-group study investigated single-dose psilocybin therapy in ten treatment-seeking adults (eight men and two women; median age 44 years) with severe AUD. The treatment involved two preparation sessions, a high-dose psilocybin session (25 mg), and two integration sessions. Pharmacokinetics were determined by noncompartmental analysis, and changes in alcohol consumption, craving and self-efficacy, were assessed with a linear mixed model.
Results Notable between-participant pharmacokinetic variations were observed, with peak plasma psilocin concentrations ranging from 14-59 µg/L. Alcohol consumption significantly decreased over the 12 weeks following psilocybin administration. Heavy drinking days were reduced by 37.5 percentage points (95% CI, -61.1, -13.9, p = 0.005), and drinks per day decreased by 3.4 units (95% CI: -6.5, -0.3), p = 0.035). This was corroborated by reports of rapid and sustained reductions in craving and increases in self-efficacy.
Conclusions Despite pharmacokinetic variations, a single 25 mg psilocybin dose was safe and effective in reducing alcohol consumption in AUD patients. Larger randomised, placebo-controlled, single-dose AUD trials are warranted.
Funding This work was supported by The Novo Nordisk Foundation (NNF19OC0058412), The Lundbeck Foundation (R-355-2020-945), The Health Foundation(21-B-0358) and The Ivan Nielsen Foundation.
Clinical trial registration: NCT05347849
An interdisciplinary perspective of the karst springs’ areas as drinking water potential: Perusal from Norteastern Slovenia
Authors: ŠPEH NATALIJA , BUBIK ANJA 
Published: August 2024

Abstract

Two karst water basins, water protection areas (WPA), the Ljubija and Rečica catchment areas, located in the north-east of Slovenia, were studied for one (COVID) year (January 2020-December 2020) to assess their freshwater quality risks facing the existing level of water protection regulations. Both groundwater (GW) and surface water (SW) were monitored twice a month in dry and wet periods to comply with European and national monitoring guidelines. For an interdisciplinary approach, an integrated indicators’ model was created to check the natural and human influences on the studied water sources. We related their water ecological conditions to the precipitation, hydro geographic and landscape characteristics of the WPAs. The Ljubija showed a low nitrate content and low fluctuations in other parameters, which declare a stable area with low human impact (the average nitrate content was 2.6 mg/l). Rečica water sources were more endangered. Their groundwater has been excluded from the drinking water supply due to organic contamination. The pollution was encouraged by the karst hydrogeological characteristics of the area. The average nitrate concentration was 6.0 mg/l. Based on the physic-chemical indicators of the water sources’ quality, we missed un upgraded monitoring regulation, especially for more vulnerable water sources as karst are.
Comparative Analysis and Classification of HTTPS Traffic Using Packet Burst Statistics: An Evaluation of State-of-the-Art Methods
Authors: ŞİMŞEK Murat , Sebetçi Özel , AKBAR Demiral 
Published: August 2024

Abstract

This study examines the classification of HTTPS traffic using packet burst statistics, a crucial aspect of modern internet usage with significant implications for network security, traffic management, and service quality. Leveraging extensive datasets from real backbone networks, we categorize HTTPS traffic into five primary types: Live Video Streaming, Video Player, Music Player, File Uploading/Downloading, and Website & Other Traffic. We employ various machine learning algorithms with particular emphasis on Random Forest and XGBoost, which demonstrate high accuracy rates. Furthermore, we incorporate recent advancements such as the Kolmogorov-Arnold Network (KAN) method for comparative analysis, enhancing the robustness of our study. We present a comprehensive methodology for model performance comparison and clustering analysis. Our findings have practical applications in network security, traffic management, and service quality enhancement. This research contributes significantly to the field, paving the way for future studies aimed at more effective classification and management of HTTPS traffic.
Experimental study on interceptor performance of bridge rainwater inlet
Authors: Wan Lijun , Zhang Zixuan , Wang Lijun , Zhao Tianrong , Geng Yuanming , Zhao Mai , Sun Xianglong 
Published: August 2024

ABSTRACT

Rainwater inlets are important for bridge drainage, and this paper carries out modeling tests on the interception performance of bridge rainwater inlets in the Daxinganling region of China. The effects of slope, different inlet methods, and grate opening forms on the interception efficiency of rainwater inlets are mainly investigated. The results show: (1) Rainwater inlet interception efficiency increases with increasing cross slope and decreases with increasing longitudinal slope. (2) The innovatively proposed inlet method of spraying above the flume, which is less efficient than the rainwater inlet interception of the diffuse flow method at the front of the flume, the inlet method is more in line with the actual situation. (3) Combined with the weir flow formula to fit the interception efficiency formula, the relative error between the predicted and measured values of the interception efficiency of the formula is less than 5%, indicating the applicability of the formula. (4) Comparing the interception efficiency of grates with different opening forms, it is concluded that the longitudinal curved opening is the best, followed by the longitudinal linear opening, and the transverse opening is the worst. In the transverse opening grates, the fewer longitudinal bars, the better the interception efficiency.
An innovative method to remove phenols from olive mill wastewater using heterogeneous modified polyacrylonitrile (PAN) catalyst
Authors: Milnes Hannah , Huddersman Katherine , Matouq Mohammed , Tiwary Abhishek , Alayed Omar , Kloub Nasir 
Published: August 2024

ABSTRACT

Phenolic compounds contained in olive oil mill wastewater (OMW) cause environmental issues when left untreated. A novel heterogeneous surface functionalised nanocoated polyacrylonitrile (PAN) mesh used as a Fentons' catalyst acting with hydrogen peroxide gave 70–100% phenol reduction and an average total organic carbon (TOC) reduction of 64.7% when seven phenols as described below were individually treated (100 mg/L phenolic, 500 mg/L H2O2, 12 g catalyst, 20 °C). As a mixture of seven phenols (100 mg/L of each, 12 g catalyst, 3,500 mg/L H2O2), such as trans-cinnamic acid, p-coumaric acid, caffeic acid, vanillic acid, ferulic acid, tyrosol and hydroxytyrosol, there was 77.5% phenol and 43.9% TOC reduction. The addition of UVc light (100 mg/L phenolic, 500 mg/L H2O2, 12 g catalyst, 20 °C, UV flux 2.66 mW/cm2) significantly improved the degradation of the initial phenolic concentration by 98% in the individual treatments. A pH of 3 and a temperature of 30 °C were found to be the most effective and efficient. The fresh and regenerated catalysts were both recycled over 10 cycles before deactivation which shows promise for continuous flow and scale-up for use as an OMW treatment.
Blockage dynamics in sewer pipes: investigating snagging, accumulation, and dissipation rates of wet wipes
Authors: Kargar Katayoun , Joksimovic Darko 
Published: August 2024

ABSTRACT
The increase in sewer blockages, exacerbated by the COVID-19 pandemic due to improper disposal of non-biodegradable items like wet wipes and sanitary products, along with fats, oils, grease, and the presence of defects in sewers, underscores the need for a more profound understanding of wipes’ contribution to these blockages. This study investigated the probability of wipe snagging on sewer imperfections and their subsequent accumulation and dissipation rates under various conditions through laboratory experiments. Findings indicated a significant variability in the likelihood of wipes snagging (ranging from 93% to 0) and accumulating (ranging from 71% to 0), which was influenced by the defect location and the sewer flow rate. Moreover, the study highlighted a direct relationship between the flow rate in the sewer and the rate at which wipes dissipate. Conversely, an inverse relationship was observed between the size of blockages and the dissipation rate of wipes, with larger blockages typically reducing the speed of this process. Importantly, while dissipation rates at low flow rates are nearly constant regardless of the number of wipes and duration, at medium to high flow rates, dissipation initially increases but levels off after 24 h, demonstrating the persistence of wipe-caused blockages in small-diameter sewer pipes.
Prediction of Prognosis and Immunotherapy Response of Gastric Cancer Based on Glutamine Metabolism-Related Genes
Authors: Gong Saisai , Yang Sheng , Zhang Tianyi , Li Jie , Wan Xin , Fang Yifei , Liu Tong , Li Chengyun , Zhou Yun , Liang Geyu 
Published: August 2024

Background:
Reprogramming of glutamine metabolism in Gastric Cancer
(GC) can significantly affect the tumor immune microenvironment and immunotherapy.
This study examines the role of glutamine metabolism in the microenvironment and
prognosis of gastric cancer.

Methods:
We obtained gene expression data and clinical information of patients from
the TCGA database. The patients were divided into two metabolic subtypes based on
consistent clustering. A prognostic risk model containing three glutamine metabolism-related
genes (GMRGs) was developed using Lasso-Cox. It was validated by the GEO
validation cohort. Additionally, the immune microenvironment composition of the highand
low-risk groups was assessed using ESTIMATE, CIBERSORT, and ssGSEA. Drug
sensitivity analysis was conducted using the “oncoPredict” R package.

Results:
We outlined the distinct clinical characteristics of two subtypes and developed
a prognostic risk model. The high-risk group has a poorer prognosis due to an increased
expression of immune checkpoints and immunosuppressive cellular infiltration. Our
analysis, which included Cox risk regression, ROC curves, and nomogram, demonstrated
that this risk model is an independent prognostic factor. The TIDE score was higher
in the high-risk group than in the low-risk group. Additionally, the high-risk group did
not respond well to chemotherapeutic drug treatment.

Conclusion:
This study shows that modelling glutamine metabolism is a good predictor
of prognosis and immunotherapy efficacy in gastric cancer. Thus, we can better understand
the role of glutamine metabolism in the development of cancer and use these insights
to develop more targeted and effective treatments.

result:
We have outlined the distinct clinical characteristics of two subtypes and developed a prognostic risk model. The high-risk group has a poorer prognosis due to an in-creased expression of immune checkpoints and immunosuppressive cellular infiltra-tio. Our analysis, which includes Cox risk regression, ROC curves, and nomogram, has shown that this risk model is an independent prognostic factor. The TIDE score was higher in the high risk group than in the low risk group. Additionally, the high-risk group did not respond as well to chemotherapeutic drug treatment.