bluuebunny/crossref_metadata_2025_split huggingface dataset:
TOWARDS Study: Patient-Derived Xenograft Engraftment Predicts Poor Survival in Patients With Newly Diagnosed Triple-Negative Breast Cancer
Authors: Vaklavas Christos , Matsen Cindy B. , Chu Zhengtao , Boucher Kenneth M. , Scherer Sandra D. , Pathi Satya , Beck Anna , Brownson Kirstyn E. , Buys Saundra S. , Chittoria Namita , D'Astous Elyse , Gulbahce H. Evin , Henry N. Lynn , Kimani Stephen , Porretta Jane , Rosenthal Regina , Ward John , Wei Mei , Welm Bryan E. , Welm Alana L. 
Published: July 2024

PURPOSE Assessing risk of recurrence for nonmetastatic triple-negative breast cancer (TNBC) is a key determinant of therapeutic strategy. The best predictor of recurrence risk is failure to achieve a pathologic complete response after preoperative chemotherapy, but it imperfectly correlates with the definitive end points of relapse-free and overall survival (OS). The inability to accurately predict recurrence has led to increasingly toxic treatment regimens for patients with early-stage TNBC. Better assays for recurrence risk are needed to tailor aggressive therapy for patients who need it and avoid overtreatment and unnecessary toxicity for those at low risk. The purpose of this study was to determine if patient-derived xenograft (PDX) engraftment of newly diagnosed breast tumors can serve as an accurate predictor of recurrence and death from breast cancer. METHODS This study was a blinded noninterventional trial comprising 80 patients with newly diagnosed, nonmetastatic, estrogen receptor (ER)-negative or ER-low breast cancer. RESULTS PDX engraftment was strongly associated with relapse in 1 year: 8 of 18 (44.4%) patients whose tumors engrafted relapsed versus 1 of 62 (1.6%) patients whose tumors did not engraft ( P < .0001). Patients whose tumors engrafted had a hazard ratio (HR) for relapse of 17.5. HRs for OS and breast cancer-specific survival in PDX+ patients were 21.1 and 39.5, respectively. CONCLUSION We report that the ability of a tumor to engraft as a PDX predicts early recurrence by serving as a functional readout of aggressiveness and prospectively identifies the most devastating tumors. This provides new opportunity to develop surrogate assays, such as biomarkers of engraftment, which will extend the clinical feasibility of this finding.
Alinesitoué Diatta: Rebel Leader or Colonial Scapegoat?
Authors: O'Donoghue Meghan 
Published: July 2024

Abstract
When a young woman named Alinesitoué Diatta received her first vision from the Jola divine entity, Emitai, Senegal was in the midst of the Second World War. Its colonial government was under Vichy French rule, West African men were forcibly conscripted into the French military, and their crops filled the army's coffers. Amid these global and regional pressures, Alinesitoué’s prophetic teachings inspired rebellion among Senegalese Casamance communities, and in 1943 the French exiled her to Timbuktu. This study examines the response to Alinesitoué’s influence by the French, who used her as a scapegoat to quell rebellion in Senegal and, in so doing, showed how colonial anxiety had been amplified to new levels during the Second World War. By analyzing newly declassified documents, this study examines the tensions between the official and confidential narratives that circulated about Alinesitoué and confirms what scholars have long suspected: Alinesitoué was not the singular rebel that the French made her out to be, and in exiling her, they endowed her with discursive and symbolic power.
Accuracy of Clinical Staging of Localized Colon Cancer: A National Cancer Database Cohort Analysis
Authors: Emile Sameh Hany , Horesh Nir , Garoufalia Zoe , Dourado Justin , Rogers Peter , Salama Ebram , Wexner Steven D 
Published: July 2024

Abstract
Background
This study aimed to assess concordance between clinical and pathologic assessment of colon cancer.

Patients and Methods
A retrospective cohort analysis of patients with stage I–III colon cancer in the National Cancer Database (2010–2019) was conducted. Concordance between clinical and pathologic assessment of colon cancer was calculated using Kappa coefficients and 95% confidence intervals (CIs).

Results
A total of 125,473 patients (51.2% female; mean age 68.2 years) were included. There was moderate concordance between clinical and pathologic T stage (Kappa = 0.606, 95%CI: 0.602–0.609) and between clinical and pathologic N stage (Kappa = 0.506, 95%CI: 0.501–0.511). For right-sided colon cancer, there was moderate agreement between clinical and pathologic T stage (Kappa = 0.594, 95%CI: 0.589–0.599) and N stage (Kappa = 0.530, 95%CI: 0.523–0.537). For left-sided colon cancer, there was substantial agreement between clinical and pathologic T stage (Kappa = 0.624, 95%CI: 0.619–0.630) and moderate agreement between N stage (Kappa 0.472, 95%CI: 0.463–0.480). Sensitivity of clinical assessment of T and N stage ranged from 64.3% to 77.2% and 41.6% to 54.5%, respectively. Specificity ranged from 96.7% to 97.7% for T stage and 95.7% to 97.3% for N stage.

Conclusions
Clinical assessment of T and N stages of colon cancer had good diagnostic accuracy with moderate concordance with the final pathologic stage. While clinical assessment was highly specific with < 3% of patients being over-staged, it had modest sensitivity, especially for detection of nodal involvement. Diagnostic accuracy of clinical assessment of right and left colon cancers was similar, except for higher sensitivity and accuracy of assessment of nodal involvement in right than left colon cancers.
Effect of a subanesthetic dose of esketamine combined with propofol on postoperative fatigue syndrome in patients undergoing gastroenterological endoscopy under anaesthesia: A retrospective study
Authors: Fei Guofang , Yan Wei , Gan Yuehua 
Published: July 2024

Objective: To assess the effect of subanesthetic dose of esketamine in combination with propofol on the incidence of postoperative fatigue syndrome (POFS) in patients who underwent gastroenterological endoscopy under anaesthesia.
Methods: Clinical data of 160 patients who underwent gastroenterological endoscopy under anaesthesia in Huzhou Maternity & Child Health Care Hospital from January to December 2022, ASA Grade- I and II, were retrospectively selected. According to the records, patients were grouped based on the administered anesthetic. Patients who received 0.2 mg/kg of esketamine and 2~2.5mg/kg of propofol comprised Group-E, and patients who were administered one μg/kg of fentanyl and 2 - 2.5mg/kg of propofol comprised Group-F. Mean arterial pressure (MAP), oxygen saturation (SpO2) and heart rate (HR) were recorded before the operation (T0), after anesthesia (T1), three minutes after the gastroscope was inserted (T2), five minutes after the colonoscope was inserted (T3) and at the end of the operation (T4). Operating time, recovery time, propofol dosage and incidence of adverse reactions in the two groups were recorded. The Christensen scores and the incidence of POFS of all patients on Day-I before operation and 1st, 3rd, and 5th days after the operation were recorded.
Results: Compared with T0, MAP, SpO2 and HR in both groups of patients decreased at T1, T2, T3 and T4 (P<0.05). MAP, SpO2 and HR of patients in Group-E were significantly higher compared to Group-F at T1, T2, T3 and T4 (P<0.05). Compared with Group-F, the recovery time, intraoperative bradycardia and respiratory depression in Group-E were significantly lower (P<0.05), and Christensen scores and the incidence of POFS decreased significantly on the 1st, 3rd, and 5th day after the operation (P<0.05).
Conclusion: Subanesthetic dose of esketamine combined with propofol can reduce POFS and postoperative adverse reactions in patients undergoing gastroenterological endoscopy.
doi: https://doi.org/10.12669/pjms.40.8.9883
How to cite this: Fei G, Yan W, Gan Y. Effect of a subanesthetic dose of esketamine combined with propofol on postoperative fatigue syndrome in patients undergoing gastroenterological endoscopy under anaesthesia: A retrospective study. Pak J Med Sci. 2024;40(8):---------. doi: https://doi.org/10.12669/pjms.40.8.9883
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Mechanizmy rozwiązywania sporów podatkowych na tle rozwiązań BEPS 2.0 Filar I
Authors: Duda-Plesińska Małgorzata 
Published: July 2024

Artykuł ma na celu przedstawienie podstawowych założeń Filaru I tzw. BEPS 2.0 i zidentyfikowanie obszarów potencjalnych sporów na tle stosowania nowych rozwiązań. W artykule zostaną przedstawione pokrótce mechanizmy prewencyjne, zorientowane na zapewnienie pewności podatkowej w związku ze stosowaniem nowych regulacji, jak również mechanizmy eliminacji podwójnego opodatkowania. Omówione zostaną dostępne obecnie mechanizmy rozstrzygania międzynarodowych sporów podatkowych. Przedmiotem dalszej części artykułu będzie analiza tego, w jakim stopniu mechanizmy te mogą posłużyć rozwiązywaniu sporów powstałych na tle stosowania rozwiązań Filaru I, a w jakim zaimplementowanie nowych zasad podziału praw do opodatkowania między krajami w odniesieniu do dochodów z działalności gospodarczej przedsiębiorstw wielonarodowych, będzie wymagało wprowadzenia nowych regulacji i jakie rozwiązania w tej materii już zostały zaproponowane.
The impact of physical activity on mental disorders
Authors: Jakubowska Katarzyna , Jerzak Aneta , Janocha Aleksandra , Ziemba Paweł 
Published: July 2024

Introduction
According to the WHO, health includes mental and social well-being, not just the absence of disease. Mental disorders are common and burdensome, with primary treatments being antidepressants and antipsychotics. However, regular physical exercise improves mental well-being and helps prevent depression, anxiety, and sleep disorders. Given the high prevalence of psychiatric disorders and their association with sedentary behavior and physical illnesses, promoting physical activity is crucial. Exercise reduces the risk of major diseases and enhances cognitive and physical health, including reducing depressive symptoms and increasing neural plasticity.

Materials and methods
The literature available in the PubMed database was searched using terms such as ‘’physical activity’’ in mental disorders.

Results
Physical activity (PA) effectively reduces symptoms and enhances cognitive functions in depression, schizophrenia, bipolar disorder, anxiety disorders, and ADHD. Beneficial exercises include walking, jogging, strength training, and yoga. In schizophrenia, PA improves symptoms and cognitive functions, mitigates medication side effects, and enhances well-being. For bipolar disorder, PA reduces mood swings and aids long-term management. Anxiety disorders and ADHD also benefit from PA, with resistance training, yoga, aerobic exercise, and swimming reducing symptoms and improving cognitive functions.

Conclusions
Regular physical activity significantly benefits psychiatric disorders and should be included as a complementary therapy. Further studies are needed to optimize PA interventions for better mental health outcomes.
Structure factor design of a liquid crystal beam steering device for augmented reality applications
Authors: Chen Yu-Min , Ou Chung-Jen , Chien Hung-Ta , Wu Jui-Yi , Tsai Ming-Wei , Chen Chien-Chih , Chen Huang-Ming Philip 
Published: July 2024

The applications of AR and VR devices have been increasingly important in our daily life. There are some disadvantages remaining to be improved for real time application. In this paper, we demonstrated the design of an experiment based on the Taguchi method targeting a beam steering liquid crystal device possessing a 6 degree steering angle with fast switching (>60Hz) ability for viewing angle expansion in AR/VR devices. The approach of the best structure design was suggested from the recall table that concluded the optical phenomenon was affected by the selected parameters from simulation. The resulting design rule was a tape-out design to prepare the pattern ITO glass. The beam steering device was assembled according to the suggested cell gap. The device evaluation showed a 6.1 degree steering angle as predicted. The response time was measured as 10.5 ms, which is able to be driven well above 60 Hz.
Rice Blast Field Assessment in Three Regencies Underlies the Importance of Fungicide Resistance Studies in West Java, Indonesia
Authors: Khairani Hagia Sophia , Abe Ayumi , Sone Teruo 
Published: July 2024

In recent decades, research about rice blast disease in Indonesia has not been focused on the dynamics of the fungus (Pyricularia oryzae) and fungicide use, which resulted in undiscovered pathogen mutations. Observations in Bogor, Cianjur, and Sukabumi Regencies in West Java reveal a high disease incidence (53%–100%), with severity ranging from 8% to 67%. The highest disease severity was recorded in Cikembar District, which is located at the foothill of Mount Gede Pangrango, Sukabumi Regency. Despite a prolonged drought caused by El Niño in 2023, Cikembar still experienced a relatively high disease severity (36%), confirming that this area remains an endemic blast area. The high disease severity, although fungicides were widely used in Cikembar, raises concerns that P. oryzae resistance to fungicides has developed, mainly to isoprothiolane which has been yearly deployed in this area. Farmers are already confronting extra challenges such as unfavorable acidic soil and differences in fungicide use practices decision-making which complicates their control efforts. Laboratory investigations are needed to validate evidence of the emergence of P. oryzae mutations against isoprothiolane in order to provide long-term recommendations for the most effective fungicide use.
High speed operation efficiency of doped light sources with the silica-doped fiber channel for extended optical fiber system reach
Authors: Gopalan Anitha , Thillaigovindan Annalakshmi , Patnala Pattabhirama Mohan , Lesley Hubert Mary , Sundaram Murugeswari , Srinivasan Vimala , Anwer Karem Tarek 
Published: July 2024

Abstract
This paper demonstrated the high speed operation efficiency of doped light sources with the silica-doped fiber channel for extended optical fiber system reach. The output power and required bias voltage are clarified of AlIn(x)Ga(y)As light source versus injection current variations and indium, gallium dopants concentration variations at room temperature and 1.55 μm wavelength. The output power and required bias voltage are studied of PAl(z)Ge(h)Sb light source versus injection current variations and aluminum, germanium dopants concentration variations at room temperature and 1.55 μm wavelength. Required resonance frequency is measured for AlIn(x)Ga(y)As light source versus injection current variations and indium, gallium dopants concentration variations at room temperature and 1.55 μm wavelength. Required resonance frequency is demonstrated for PAl(z)Ge(h)Sb light source versus injection current variations and aluminum, germanium dopants concentration variations at room temperature and 1.55 μm wavelength.
DeepQR: single-molecule QR codes for optical gene-expression analysis
Authors: Jeffet Jonathan , Hadad Barak , Froim Sahar , Kaboub Kawsar , Rabinowitz Keren M. , Deek Jasline , Margalit Sapir , Dotan Iris , Bahabad Alon , Ebenstein Yuval 
Published: July 2024

Abstract
Optical imaging and single-molecule imaging, in particular, utilize fluorescent tags in order to differentiate observed species by color. The degree of color multiplexing is dependent on the available spectral detection window and the ability to distinguish between fluorophores of different colors within this window. Consequently, most single-molecule imaging techniques rely on two to four colors for multiplexing. DeepQR combines compact spectral imaging with deep learning to enable 4 color acquisition with only 3 spectral detection windows. It allows rapid high-throughput acquisition and decoding of hundreds of unique single-molecule color combinations applied here to tag native RNA targets. We validate our method with clinical samples analyzed with the NanoString gene-expression inflammation panel side by side with the commercially available NanoString nCounter system. We demonstrate high concordance with “gold-standard” filter-based imaging and over a four-fold decrease in acquisition time by applying a single snapshot to record four-color barcodes. The new approach paves the path for extreme single-molecule multiplexing.
Steady-state thermodynamic process in multilayered heterogeneous cylinder
Authors: Mubaraki Ali M. , Nuruddeen Rahmatullah Ibrahim 
Published: July 2024

Abstract
The present study formulates and further examines a steady-state heat diffusion process in a generalized multilayered heterogeneous circular composite. Sufficient boundary and interfacial data are assumed at the endpoints of the circumferential length, and the interfaces, cutting across the respective perfectly welded cylinders. A well-known classical method for solving linear partial differential equations has been sought to derive a compacted solution for the diffusion process in governing heterogeneous cylinders. Certainly, among the significant novel findings of the current study is the acquisition of a generalized series solution for

m

m

-body multilayered heterogeneous circular composites, in addition to the portrayal of simple, yet an efficient method for solution; away from sophisticated numerical methods or integral transform methods that are not always invertible analytically. Moreover, three prototype situations of the structure have been profoundly examined, which are then found to satisfy all imposed structural assumptions. Moreover, the current examination finds relevance in the study and the analysis and design of multilayered bodies in engineering, material science, thermodynamics, and solid mechanics.
The role of environmental pollution in the development of pulmonary exacerbations in cystic fibrosis: a narrative review
Authors: Zamarrón Ester , Mariscal Pablo , Carpio Carlos , Esteban Lucía , Álvarez-Sala Rodolfo , Prados María Concepción 
Published: July 2024

Abstract
Cystic fibrosis is the most common autosomal recessive disease in the Caucasian race. Its course is chronic and progressive, with pulmonary involvement being associated with greater morbidity and mortality. One of the factors most related to worse prognosis in these patients is respiratory exacerbations. Although limited, there is evidence demonstrating that increased exposure to environmental pollution, both acute and chronic, is associated with an increase in these exacerbations. It is crucial to fully understand this relationship in order to attempt to improve the respiratory health of these patients. That is why the available evidence is reviewed and measures are established to reduce exposure to pollutants.
Between Privacy, Alienation and Community
Authors: Scapinello Francesca 
Published: July 2024

Abstract
This paper is concerned with Stanley Cavell’s reading of the notion of privacy as it appears in Ludwig Wittgenstein’s private language argument (PLA). Defined as a fantasy or fear either of inexpressiveness or excessive expressiveness (cf. Cavell 1979: 254), I argue that such an account is partial, in that it does not represent those individuals that are exposed to epistemic injustice. Drawing on Miranda Fricker’s seminal work Epistemic Injustice (2007) and on Frantz Fanon’s Black Skin, White Masks (1952), I trace some similarities between the conditions of marginalized subjectivities and the private language speaker. This comparison suggests a correction of Cavell’s words and discloses an understanding of the clarificatory import that Wittgenstein’s PLA conveys, rendering it a way to resist marginalization and alienation due to the logical impossibility of a private language.
In the second part of the paper (section 3), I consider two other Cavellian notions, namely the “claim to community” and ‘the turn to the ordinary’. Following the line of criticism developed in section 2, which revolves around the need of considering the situatedness of marginalized subjectivities and the oppressive character of the dimension of the ordinary, I try to implement Cavell’s concepts. I do so by taking into account (i) the Wittgenstein-inspired wider conception of rationality Alice Crary (2015) purports and (ii) the practices of some feminist consciousness-raising groups that were active in Milan (Italy) during the Seventies and some ideas developed by feminist and art critic Carla Lonzi. These contributions show that it is possible to maintain the general asset purported by Cavell, but they also call for criteria for better defining on which principles a community can form and which role the collectivity plays in revising the structure of the ordinary.
Sex Differences in Physiological Responses to a National Collegiate Athletic Association Division I Soccer Season
Authors: McFadden Bridget A. , Walker Alan J. , Cintineo Harry P. , Bozzini Brittany N. , Sanders David J. , Chandler Alexa J. , Arent Shawn M. 
Published: July 2024

Abstract
McFadden, BA, Walker, AJ, Cintineo, HP, Bozzini, BN, Sanders, DJ, Chandler, AJ, and Arent, SM. Sex differences in physiological responses to a national collegiate athletic association division I soccer season. J Strength Cond Res XX(X): 000–000, 2024—Identifying physiological changes that occur in response to workload demands can help to elucidate athlete management and recovery strategies. The purpose of this study was to compare the physical and physiological demands between men and women throughout the course of a collegiate soccer season. Men (N = 23) and women (N = 26) soccer players participated in blood draws before preseason (T1) and every 4 weeks thereafter (T2–T4). Workload was determined at all practices and games via heart rate and global positioning satellite monitoring systems. Repeated measures multivariate analysis of variance and linear mixed models were used to assess workload and biomarker responses throughout the season (p < 0.05). Both teams experienced the highest workloads during the first 4 weeks of the season (p < 0.05), which was followed by several biomarker perturbations. Sex-by-Time interactions were observed for total cortisol, growth hormone, insulin-like growth factor-1, thyroxine, thyroid-stimulating hormone, vitamin D, and omega 3 fatty acid index (p < 0.05). Additional Sex effects were observed for free and total testosterone, estrogen, prolactin, sex-hormone binding globulin, creatine kinase, and iron levels (p < 0.05). Women soccer players experienced further Time effects for free cortisol, iron, ferritin, and percent transferrin saturation (p < 0.05). Male soccer players experienced additional Time effects for total testosterone, estrogen, creatine kinase, interleukin-6, triiodothyronine, and ferritin (p < 0.05). Despite similar patterns of change in workloads, differential fluctuations in physiological markers were observed between the sexes. Understanding sex differences in response to comparable workloads may enhance exercise prescriptions for better athlete management plans. Additional strategies to increase iron may be warranted in female athletes.