bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contrasting Discrepancy in the Sea Level Budget Between the North and South Atlantic Ocean Since 2016
Authors: Mu Dapeng , Church John A. , King Matt , Ludwigsen Carsten Bjerre , Xu Tianhe 
Published: August 2024

AbstractThe discrepancy in the observed global mean sea level budget increased significantly since 2016, but the budget discrepancy over basin‐scales is unclear. In this contribution, we investigate the sea level budget discrepancies in major basins with observations from satellite altimetry, satellite gravimetry, and Argo floats. During 2016–2020, we find substantial discrepancy of 5.72 ± 0.98 mm/yr over the North Atlantic Ocean, and the basin scale discrepancies are smaller elsewhere. Our analysis suggests that three factors, including the wet tropospheric correction (WTC) effect, deep ocean warming signal, and the contemporary ocean bottom deformation (OBD), together reduce the discrepancy by only 1 mm/yr for the North Atlantic Ocean. We decompose sea level observations into the spherical harmonic domain and observe increased discrepancy in low‐degree variations of C10 and C21 since 2016. These two coefficients result in a contrasting signal between the North and South Atlantic Ocean and contribute to the large discrepancy over the North Atlantic Ocean. We further demonstrate that the C10 and C21 discrepancies are independent of the three factors. However, we find regional salinity biases in the Argo data that reduce the discrepancy for the North Atlantic Ocean. Our findings add to the debate about recent sea level budget and imply that further analysis of the Argo North Atlantic data set may be useful.
Substantial Overestimation of Terrestrial Water Storage Loss in Headwater Basins on Earth's Third Pole
Authors: Qiao Baojin , Li Na , Cui Jiangpeng , Li Dongfeng , Li Mengyao , Xiang Longwei , Borrelli Pasquale , Famiglietti Jay 
Published: August 2024

AbstractThe Tibetan Plateau (TP) is suffering from a substantial decline in terrestrial water storage (TWS) in exorheic basins, threatening water resources that are critical for ∼2 billion people downstream. TWS changes are commonly estimated using gravity satellites through observations of the total terrestrial mass storage (TMS) change, with an implicit assumption of a negligible contribution from sediment transport. Through long‐term (2002–2017) sediment flux observations in seven headwater basins on the TP, we reveal that the gravity satellite‐derived TMS has decreased at a rate of 3.85 ± 0.23 Gt yr−1 in the seven basins, of which 0.35 ± 0.04 Gt yr−1 is contributed by sediment transport. Neglecting this contribution leads to an overestimation of the TWS loss by 10.1 ± 1.3%, equivalent to the annual water demand of an additional 0.62 million people in the surrounding nations. Regionally, the overestimation is surprisingly high in the Indus River and Yarkant River basins, reaching up to 50.8%–77.6%.
Comparison of the Occurrence Morphology of Phase Scintillation of GPS and Beidou Signals at Zhongshan Station, Antarctica
Authors: Wang Li‐Yan , Zhang Qing‐He , Wang Fei‐Fei , Wang Yong , Xing Zan‐Yang , Ma Yu‐Zhang , Liu Jian‐Jun , Hu Ze‐Jun , Chen Xiang‐Cai , Hu Hong‐Qiao , Lu Sheng , Xiu Zhi‐Feng , Jayachandran P.T. 
Published: August 2024

AbstractThe characteristics of phase scintillation (represented by the phase scintillation indices, σφ) from GPS and Beidou are statistically analyzed using a ground‐based receiver at Zhongshan Station, Antarctica, from 2020 to 2022 for the first time. The phase scintillation of the GPS and Beidou signals present a similar pattern of occurrence. The statistical results on the occurrence morphology of phase scintillation show that the phase scintillation predominately occurs in the magnetic pre‐noon and pre‐midnight sectors. Moreover, phase scintillation performs a dependence on solar and geomagnetic activities. Furthermore, the phase scintillation also gives a seasonal variation with the maximum occurrence happened at the autumn and the minimum occurrence during the summer. Consequently, these results improve understanding of the morphological characteristics of the phase fluctuations in the less studied Antarctic region. The study also demonstrates the use of the combined data set to improve the coverage in the Antarctic region.
The Influence of Coral Reef Spur and Groove Morphology on Wave Energy Dissipation in Contrasting Reef Environments
Authors: Perris Lachlan , Salles Tristan , Fellowes Thomas E. , Duce Stephanie , Webster Jody , Vila‐Concejo Ana 
Published: August 2024

AbstractCoral reefs protect coastlines from inundation and flooding and serve over 200 million people globally. Wave transformation has previously been studied on coral reef flats with limited focus on forereef zones where wave transformation is greatest during high‐energy conditions. This study investigates the role of forereef spur and groove (SaG) morphology in wave energy dissipation and transmission at the reef crest. Using XBeach on LiDAR‐derived bathymetry from One Tree Island in the southern Great Barrier Reef, we reproduced dissipation rates comparable to SaG field studies. We examined how wave energy dissipation differs between realistic bathymetry and those with SaG features removed, demonstrating an up to 40% decrease in dissipation when SaG features are absent. We then investigated changes to wave energy dissipation and wave transmission at the reef crest based on IPCC AR5 emission scenarios (RCP2.6 and RCP8.5) and a total disaster scenario (TD) for the year 2100. For RCP2.6, an increase in wave heights of 0.8 m and an increase in water level of 0.3 m resulted in a two‐fold increase in dissipation rates. For RCP8.5 and TD, with no increase in incident wave height, dissipation rates were 29% and 395% lower than RCP2.6. This resulted in increased wave transmission at the reef crest by 1.8 and 2.7 m for the RCP8.5‐ and TD based models, respectively, when compared to the RCP2.6‐based model. The results from our novel modeling approach of using long‐shore varying accurate bathymetry on forereefs show increased wave energy dissipation rates with implications for reducing coastal flooding and island inundation on reef‐lined coasts.
Impacts of the Early Eocene Climatic Optimum (EECO, ∼53‐49 Ma) on Planktic Foraminiferal Resilience
Authors: Filippi Giulia , Barrett Ruby , Schmidt Daniela N. , D'Onofrio Roberta , Westerhold Thomas , Brombin Valentina , Luciani Valeria 
Published: August 2024

Plain Language SummaryThe Early Eocene Climatic Optimum (EECO) is an interval of prolonged warmth that occurred ∼53 to 49 million years ago. Planktic foraminifera are important (alongside coccolithophores) for understanding the carbon cycle and determining export production in the ocean. To understand how foraminifera can be impacted by extreme heat, we analyzed samples from the Pacific Ocean through measuring changes in (a) the relative abundance, that is, the count of different taxa in a sample, and (b) body (shell) size of planktic foraminifera. At the start of the EECO, the abundance of the genera Morozovella and Chiloguembelina decreased. Despite this decline, the number of foraminifera being buried and the size of the largest shells in a sample does not change. We attribute this to the increased abundance of the genus Acarinina. In general, the accumulation of foraminifera remains stable while the relative abundance of foraminifera to coccolithophores decreases. Together, this implies that coccolithophores are increasing in abundance, and/or mass. During the EECO, one group of foraminifera was able to counterbalance the decrease in abundance of other genera. This highlights the resilience of open‐ocean carbonate production and the base of the marine food web.
The Moderating Influence of Spring Climate on the Rio Grande Headwaters: A Paleo Perspective
Authors: Woodhouse C. A. , Tintor W. L. 
Published: August 2024

AbstractWhile snowpack is the main influence on Rio Grande water year streamflow, spring hydroclimate can play a role in moderating this influence in a subset of years. Through an investigation of the relationship between winter snowpack and spring hydroclimate conditions and Rio Grande streamflow, we find low snowpack years with relatively cool, wet springs coincide with slightly above median streamflow in 18% of the years in the instrumental record (1936–2018), while the opposite conditions occur during 24% of years. Over this period, an increase in years with low snowpack/cool wet springs is evident, likely due to a significant decreasing trend in snowpack. We analyze two 15‐century tree‐ring reconstructions to provide long‐term context for the variable relationship between snowpack and spring hydroclimate. Results suggests irregular but quasi‐multidecadal periods when spring conditions may have moderated the effect of a relatively dry winter or reduced the effect of a relatively wet winter. The reconstructions also provide context for the observed trend in the increasing importance of spring conditions over the instrumental period, which appears to be related to both natural climate variability and climate change. In the Rio Grande basin, as mountain snowpack declines due to warming temperatures, spring conditions may be playing an increasingly important role for water resources, at least in the near term.
Pivotal Role of Mixed‐Layer Depth in Tropical Atlantic Multidecadal Variability
Authors: Senapati Balaji , O’Reilly Christopher H. , Robson Jon 
Published: August 2024

AbstractThe tropical arm of Atlantic Multidecadal Variability (AMV) influences climate worldwide, yet the mechanisms generating it remain unclear. Here, we examine experiments with sea surface temperature (SST)‐restoring in the extratropical North Atlantic in multiple models and use mixed‐layer heat budgets to elucidate the important mechanisms. Our results demonstrate that the tropical AMV is driven by wind‐mixed‐layer‐SST feedback. The evolution has two phases with tropical AMV SST anomalies growing from April to October and decaying from November to March. The amplitude of the growth phase surpasses that of the decay phase, resulting in overall tropical Atlantic warming during positive AMV phases. During summer, positive SST anomalies in the extratropics weaken the trade winds, resulting in a shallower mixed‐layer with reduced heat capacity. Subsequent absorption of climatological shortwave radiation in this shallower mixed‐layer then causes SSTs to warm, generating the tropical AMV. Importantly, anomalous surface heat‐fluxes make modest contributions to tropical AMV in these experiments.
Lightning‐Induced Energetic Electron Precipitation Observed in Long‐Term DEMETER Spacecraft Measurements
Authors: Linzmayer V. , Němec F. , Santolík O. , Kolmašová I. 
Published: August 2024

AbstractWe analyze low‐altitude DEMETER spacecraft measurements obtained between 2006 and 2010, complemented by WWLLN lightning location data, to investigate the importance of lightning‐generated whistlers for the energetic electron precipitation from the Van Allen radiation belts. We focus, in particular, on the United States region, where a significant seasonal variation in the occurrence of lightning has been observed. We show that both the precipitating electron fluxes and very low frequency wave intensities correlate well with the total lightning occurrence in the region. We further demonstrate that lightning‐induced electron precipitation is more significant during periods of low geomagnetic activity compared to periods of high geomagnetic activity and during the nighttime than during the daytime. The energies of precipitating energetic electrons extend up to about 700 keV, roughly in agreement with the cyclotron resonance theory.
GNAS knockout potentiates HDAC3 inhibition through viral mimicry-related interferon responses in lymphoma
Authors: He Michael Y. , Tong Kit I. , Liu Ting , Whittaker Hawkins Ryder , Shelton Victoria , Zeng Yong , Bakhtiari Mehran , Xiao Yufeng , Zheng Guangrong , Sakhdari Ali , Yang Lin , Xu Wenxi , Brooks David G. , Laister Rob C. , He Housheng Hansen , Kridel Robert 
Published: August 2024

AbstractDespite selective HDAC3 inhibition showing promise in a subset of lymphomas with CREBBP mutations, wild-type tumors generally exhibit resistance. Here, using unbiased genome-wide CRISPR screening, we identify GNAS knockout (KO) as a sensitizer of resistant lymphoma cells to HDAC3 inhibition. Mechanistically, GNAS KO-induced sensitization is independent of the canonical G-protein activities but unexpectedly mediated by viral mimicry-related interferon (IFN) responses, characterized by TBK1 and IRF3 activation, double-stranded RNA formation, and transposable element (TE) expression. GNAS KO additionally synergizes with HDAC3 inhibition to enhance CD8+ T cell-induced cytotoxicity. Moreover, we observe in human lymphoma patients that low GNAS expression is associated with high baseline TE expression and upregulated IFN signaling and shares common disrupted biological activities with GNAS KO in histone modification, mRNA processing, and transcriptional regulation. Collectively, our findings establish an unprecedented link between HDAC3 inhibition and viral mimicry in lymphoma. We suggest low GNAS expression as a potential biomarker that reflects viral mimicry priming for enhanced response to HDAC3 inhibition in the clinical treatment of lymphoma, especially the CREBBP wild-type cases.
Ribosomal modification protein rimK-like family member A activates betaine-homocysteine S-methyltransferase 1 to ameliorate hepatic steatosis
Authors: Yan Han , Liu Wenjun , Xiang Rui , Li Xin , Hou Song , Xu Luzheng , Wang Lin , Zhao Dong , Liu Xingkai , Wang Guoqing , Chi Yujing , Yang Jichun 
Published: August 2024

AbstractNonalcoholic fatty liver disease (NAFLD) is a serious threat to public health, but its underlying mechanism remains poorly understood. In screening important genes using Gene Importance Calculator (GIC) we developed previously, ribosomal modification protein rimK-like family member A (RIMKLA) was predicted as one essential gene but its functions remained largely unknown. The current study determined the roles of RIMKLA in regulating glucose and lipid metabolism. RIMKLA expression was reduced in livers of human and mouse with NAFLD. Hepatic RIMKLA overexpression ameliorated steatosis and hyperglycemia in obese mice. Hepatocyte-specific RIMKLA knockout aggravated high-fat diet (HFD)-induced dysregulated glucose/lipid metabolism in mice. Mechanistically, RIMKLA is a new protein kinase that phosphorylates betaine-homocysteine S-methyltransferase 1 (BHMT1) at threonine 45 (Thr45) site. Upon phosphorylation at Thr45 and activation, BHMT1 eliminated homocysteine (Hcy) to inhibit the activity of transcription factor activator protein 1 (AP1) and its induction on fatty acid synthase (FASn) and cluster of differentiation 36 (CD36) gene transcriptions, concurrently repressing lipid synthesis and uptake in hepatocytes. Thr45 to alanine (T45A) mutation inactivated BHMT1 to abolish RIMKLA’s repression on Hcy level, AP1 activity, FASn/CD36 expressions, and lipid deposition. BHMT1 overexpression rescued the dysregulated lipid metabolism in RIMKLA-deficient hepatocytes. In summary, RIMKLA is a novel protein kinase that phosphorylates BHMT1 at Thr45 to repress lipid synthesis and uptake. Under obese condition, inhibition of RIMKLA impairs BHMT1 activity to promote hepatic lipid deposition.
Divalent vinyl ketones derived from fluorene: a facile synthesis of bifunctional acrylic monomers with high reactivity in thia-/aza-Michael addition and Morita-Baylis-Hillman reactions
Authors: Ohyama Masatoshi , Yasuda Rie , Miyauchi Shinsuke , Kohsaka Yasuhiro 
Published: August 2024

AbstractAlthough vinyl ketones (VKs) exhibit excellent reactivity toward radicals and nucleophiles, their application in polymer chemistry has been limited compared with that of acrylates. One of the reasons is the difficulty of the synthesis, particularly that of multivalent VKs. Herein, we report the facile synthesis of divalent VKs via Friedel‒Crafts acylation of fluorene and subsequent elimination reactions. For example, via this approach, 2,7-diacryloyl-9,9-dimethylfluorene was obtained at high yields (78%). Because the monomer was obtained at high purity through recrystallization and washing, the procedure is suitable for industrial applications. The addition of dithiols and diamines via thia- and aza-Michael addition afforded the corresponding polythioesters and polyamines, respectively. In addition, the divalent VKs exhibited high reactivity in the Morita‒Baylis‒Hillman reaction with formaldehyde, affording a diol monomer. The polycondensation of the diol monomer and isophthaloyl dichloride yielded a poly(conjugated-ketone ester). Consequently, the divalent VKs described herein are attractive monomers and monomer precursors with ready accessibility and sufficient electrophilicity.
Muscle quality index comparisons between Hispanics and non-Hispanic Caucasians using dual energy X-ray absorptiometry and handgrip strength
Authors: Mehra Ayush , Snarr Ronald L. , Park Kyung-Shin , Krok-Schoen Jessica L. , Czerwinski Stefan A. , Nickerson Brett S. 
Published: August 2024

Abstract
Background & Aims
Muscle quality index (MQI) can be computed in various ways. Also, many studies have evaluated MQI in older adults and non-Hispanic populations. The aim of this study was to compare various muscle quality indexes between Hispanics and non-Hispanic Caucasians when stratifying grip strength and appendicular lean mass measurements.

Methods
235 participants (aged 25.5 ± 9.5 for males and 26.4 ± 9.9 for females) completed a dual energy X-ray absorptiometry (DXA) scan to assess appendicular lean mass (ALM). Handgrip strength (HGS) was assessed using a handheld dynamometer. MQI was computed using four different models: 1). MQIRA: ALM and HGS of right arm and hand, respectively; 2). MQILA: ALM and HGS of left arm and hand, respectively; 3). MQIARMS: ALM and HGS of both arms and hands, respectively; and 4). MQITOTAL: ALM of upper and lower-limbs and HGS of left and right hand.

Results
Hispanic males and females exhibited lower HGS compared to Caucasians with effect sizes ranging from trivial (d = 0.17) to moderate (d = 0.80). Females demonstrated higher MQI values compared to males for MQIARMS (d = 0.70), MQIRA (d = 0.75), and MQILA (d = 0.57). However, MQITOTAL yielded a small practical effect (d = 0.33) in favor of males (3.2 ± 0.5 kg/kg vs. 3.1 ± 0.5 kg/kg). After factoring by sex and ethnicity, Hispanic males and females, compared to non-Hispanic Caucasians males and females, showed trivial-to-small practical differences (d values ranging from 0.03 to 0.39).

Conclusions
These results demonstrate MQI models vary across sex, particularly when utilizing models that account for upper extremity strength and ALM (i.e., MQIARMS, MQIRA, and MQILA). Lastly, to establish consistency in future research, the present study recommends using MQI models that account for ALM of upper- and lower-limbs (i.e., MQITOTAL). However, research measuring muscular strength via one upper-limb (e.g., left hand) might consider measuring ALM of the corresponding arm (e.g., left arm) when computing muscle quality (e.g., MQILA).
The association of birth weight and current BMI on the risk of hypertension: the Tohoku medical megabank community-based cohort study
Authors: Himuro Hiromi , Kogure Mana , Nakaya Naoki , Nakamura Tomohiro , Hatanaka Rieko , Chiba Ippei , Nakaya Kumi , Tsuchiya Naho , Hirata Takumi , Orui Masatsugu , Kobayashi Tomoko , Kodama Eiichi N. , Hamanaka Yohei , Uruno Akira , Fuse Nobuo , Nagaie Satoshi , Ogishima Soichi , Ishikuro Mami , Obara Taku , Izumi Yoko , Saito Masatoshi , Kuriyama Shinichi , Hozawa Atsushi , Sugawara Junichi 
Published: August 2024

AbstractThis study aimed to investigate the association of combination of birth weight and current body mass index (BMI) with the risk of hypertension in adulthood. This cross-sectional study used data from the Tohoku Medical Megabank Community-based Cohort Study conducted in Japan. A total of 10,688 subjects aged ≥20 years were eligible. We calculated the least square (LS) means of systolic blood pressure (SBP) and trend tests were performed to evaluate the linear relationships between birth weight categories and SBP. We also used a multivariate logistic regression analysis to assess the risk of hypertension associated with the combination of birth weight and current BMI. There was a statistically inverse association between birth weight and SBP in the 20–64 age group, but no significant association in the ≥65 age group. Low birth weight (LBW) with normal BMI group had a higher risk of hypertension than the normal or high birth weight groups with normal BMI. Furthermore, the group with LBW and BMI ≥25.0 kg/m2 was the highest risk for hypertension (adjusted odds ratio: 2.73; 95% CI, 2.04–3.65) compared to the reference group (birth weight 2500–3499 g and BMI 18.5–24.9 kg/m2). There was a significant association between LBW and subsequent risk of hypertension. In addition, participants with lower birth weights had a higher risk of hypertension than those with higher birth weights. However, even in participants with a lower birth weight, the risk of hypertension could be reduced when they maintained an optimal BMI.
Hydrogel mechanical properties in altered gravity
Authors: Mišković Vanja , Greco Immacolata , Minetti Christophe , Cialdai Francesca , Monici Monica , Gazzi Arianna , Marcellino Jeremiah , Samad Yarjan Abdul , Delogu Lucia Gemma , Ferrari Andrea C. , Iorio Carlo Saverio 
Published: August 2024

AbstractExposure to altered gravity influences cellular behaviour in cell cultures. Hydrogels are amongst the most common materials used to produce tissue-engineering scaffolds, and their mechanical properties play a crucial role in cell-matrix interaction. However, little is known about the influence of altered gravity on hydrogel properties. Here we study the mechanical properties of Poly (ethylene glycol) diacrylate (PEGDA) and PEGDA incorporated with graphene oxide (GO) by performing tensile tests in micro and hypergravity during a Parabolic flight campaign, and by comparing them to the same tests performed in Earth gravity. We show that gravity levels do not result in a statistically significant difference in Young’s modulus.
A hybrid reanalysis-forecast meteorological forcing data for advancing climate adaptation in agriculture
Authors: Iizumi Toshichika , Takimoto Takahiro , Masaki Yoshimitsu , Maruyama Atsushi , Kayaba Nobuyuki , Takaya Yuhei , Masutomi Yuji 
Published: August 2024

AbstractClimate variability in the growing season is well suited for testing adaptation measures. Adaptation to adverse events, such as heatwaves and droughts, increases the capacity of players in agri-food systems, not only producers but also transporters and food manufacturers, to prepare for production disruptions due to seasonal extremes and climate change. Climate impact models (e.g., crop models) can be used to develop adaptation responses. To run these models, historical records and climate forecasts need to be combined as a single daily time series. We introduce the daily 0.5° global hybrid reanalysis-forecast meteorological forcing dataset from 2010 to 2021. The dataset consists of the Japanese 55-yr Reanalysis (JRA55) and the Japan Meteorological Agency/Meteorological Research Institute Coupled Prediction System version 2 (JMA/MRI-CPS2) 5-member ensemble forecast. Both are bias-corrected using the Delta method and integrated with a baseline climatology derived from the Environmental Research and Technology Development Fund’s Strategic Research 14 Meteorological Forcing Dataset (S14FD). The dataset is called JCDS (JRA55-CPS2-Delta-S14FD) and offers a framework for monitoring and forecasting applications towards adaptation.