bluuebunny/crossref_metadata_2025_split huggingface dataset:
Accuracy of the defining characteristics of respiratory nursing diagnoses in patients with COVID‐19
Authors: Maurício Aline Batista , Cavalcante Agueda Maria Ruiz Zimmer , de Sá Erika Silva , Bruni Larissa Giardini , Vieira Larissa Gabrielle Dias , Costa Adriana , França Letícia Diniz , Lopes Marcos Venícios de Oliveira , de Barros Alba Lucia Bottura Leite , da Silva Viviane Martins 
Published: July 2024

AbstractObjectiveTo analyze the accuracy of the defining characteristics of four respiratory nursing diagnoses (ND) in patients with COVID‐19 and on oxygen therapy.MethodsThis is a cross‐sectional study conducted in four Brazilian public hospitals in two regions of the country. A total of 474 patients with COVID‐19 receiving oxygen therapy were assessed. Latent‐adjusted class analysis with random effects was used to establish the sensitivity (Se) and specificity (Sp) of the defining characteristics evaluated for each ND.ResultsAmong the ND that constituted the study (impaired spontaneous ventilatory, impaired gas exchange, ineffective airway clearance, and dysfunctional ventilatory weaning response), the following defining characteristics had the highest simultaneous Se and Sp (>0.8): decrease in tidal volume, confusion, irritability, dyspnea, decreased breath sounds, orthopnea, impaired ability to cooperate and respond to coaching, and decrease in the level of consciousness.ConclusionsRecognizing the clinical signs that predict respiratory ND in patients affected by COVID‐19 can contribute to the nurse's accurate diagnostic inference and designate the appropriate nursing interventions to achieve the desired results and avoid complications.
The number of comorbidities as an important cofactor to ASA class in predicting postoperative outcome: An international multicentre cohort study
Authors: Grob Christian A. , Angehrn Luzius W. , Kaufmann Mark , Hahnloser Dieter , Winiker Michael , Erb Thomas O. , Joller Sonja , Schumacher Philippe , Bruppacher Heinz R. , O'Grady Gregory , Murtagh Jonathon , Gawria Larsa , Albers Kim , Meier Sonja , Heilbronner Samuel Anna R. , Schindler Christian , Steiner Luzius A. , Dell‐Kuster Salome 
Published: July 2024

AbstractBackgroundMultimorbidity is a growing burden in our ageing society and is associated with perioperative morbidity and mortality. Despite several modifications to the ASA physical status classification, multimorbidity as such is still not considered. Thus, the aim of this study was to quantify the burden of comorbidities in perioperative patients and to assess, independent of ASA class, its potential influence on perioperative outcome.MethodsIn a subpopulation of the prospective ClassIntra® validation study from eight international centres, type and severity of anaesthesia‐relevant comorbidities were additionally extracted from electronic medical records for the current study. Patients from the validation study were of all ages, undergoing any type of in‐hospital surgery and were followed up until 30 days postoperatively to assess perioperative outcomes. Primary endpoint was the number of comorbidities across ASA classes. The associated postoperative length of hospital stay (pLOS) and Comprehensive Complication Index (CCI®) were secondary endpoints. On a scale from 0 (no complication) to 100 (death) the CCI® measures the severity of postoperative morbidity as a weighted sum of all postoperative complications.ResultsOf 1421 enrolled patients, the mean number of comorbidities significantly increased from 1.5 in ASA I (95% CI, 1.1–1.9) to 10.5 in ASA IV (95% CI, 8.3–12.7) patients. Furthermore, independent of ASA class, postoperative complications measured by the CCI® increased per each comorbidity by 0.81 (95% CI, 0.40–1.23) and so did pLOS (geometric mean ratio, 1.03; 95% CI, 1.01–1.06).ConclusionsThese data quantify the high prevalence of multimorbidity in the surgical population and show that the number of comorbidities is predictive of negative postoperative outcomes, independent of ASA class.
Established the prediction model of early‐stage non‐small cell lung cancer spread through air spaces (STAS) by radiomics and genomics features
Authors: Wang Yimin , Li Chuling , Wang Zhaofeng , Wu Ranpu , Li Huijuan , Meng Yunchang , Liu Hongbing , Song Yong 
Published: July 2024

AbstractBackgroundThis study was aimed to establish a prediction model for spread through air spaces (STAS) in early‐stage non‐small cell lung cancer based on imaging and genomic features.MethodsWe retrospectively collected 204 patients (47 STAS+ and 157 STAS−) with non‐small cell lung cancer who underwent surgical treatment in the Jinling Hospital from January 2021 to December 2021. Their preoperative CT images, genetic testing data (including next‐generation sequencing data from other hospitals), and clinical data were collected. Patients were randomly divided into training and testing cohorts (7:3).ResultsThe study included a total of 204 eligible patients. STAS were found in 47 (23.0%) patients, and no STAS were found in 157 (77.0%) patients. The receiver operating characteristic curve showed that radiomics model, clinical genomics model, and mixed model had good predictive performance (area under the curve [AUC] = 0.85; AUC = 0.70; AUC = 0.85).ConclusionsThe prediction model based on radiomics and genomics features has a good prediction performance for STAS.
Effects of residential mobility on impression formation across different social contexts
Authors: Fang Yuchen , Komiya Asuka 
Published: July 2024

AbstractResearch on residential mobility is burgeoning; however, only a few studies have examined this topic in the context of impression formation. In Study 1, we first examined the hypothesis that high residential mobility increases sensitivity to friendliness, whereas low residential mobility increases sensitivity to hostility. In the word completion task, no effects of residential mobility were observed; however, in the impression formation task, participants with high residential mobility perceived friendly new acquaintances with higher amicability than those with low residential mobility (Studies 1a and 1c). Meanwhile, no effect was observed with the hostile new acquaintances (Study 1b). The results suggest that the effects of residential mobility, with a focus on friendliness and hostility, may be highly context dependent. Study 2 partially confirmed this idea, showing that participants with low residential mobility perceived hostile old acquaintances as less friendly than those with high residential mobility, and there was no effect of residential mobility in the case of friendly old acquaintances (Study 3). The role of residential mobility on impression formation was discussed.
Ultra‐high‐frequency ultrasound (48–70 MHz) is a promising tool for improved gastrointestinal diagnostics in infants
Authors: Jacobsen Ronni Bengtson , Hebelka Hanna , Gatzinsky Vladimir , Elfvin Anders , Dangardt Frida 
Published: July 2024

AbstractAimTo investigate the clinical feasibility of ultra‐high‐frequency abdominal ultrasound (UHFUS) scans of preterm and term infants.MethodsProspectively, 19 healthy term newborn infants were examined with conventional ultrasound (CUS) (Toshiba, Aplio i700, linear probe 14L5) and UHFUS (Visualsonics VevoMD, linear probes UHF48 and UHF70) according to a standardised protocol. Measurements of wall thickness were performed for; stomach, small intestine, colon and peritoneum. Five preterm infants, with or without suspected necrotising enterocolitis (NEC), were also examined with UHF48. Of these, only one was later diagnosed with NEC.ResultsDifferences between CUS and UHFUS (UHF48) were found in measurements of thickness; for peritoneum 0.25 versus 0.13 mm (p < 0.001), small intestine 0.76 versus 0.64 mm (p = 0.039) and colon 0.7 versus 0.47 mm (p < 0.001) in healthy term infants. Gaining frequency from 46 to 71 MHz showed a mean reduction in measurements of peritoneum from 0.13 to 0.09 mm (p < 0.001). One preterm infant with NEC showed a fivefold and twofold increase in peritoneal and gastrointestinal wall thickness respectively, compared to healthy preterm infants.ConclusionUHFUS was a clinically feasible, promising method with potential to improve gastrointestinal diagnostics in infants. Lower peritoneum thickness and gastrointestinal wall thickness were demonstrated with UHFUS compared to CUS, suggesting an overestimation by CUS.
Genetic relationship of energy balance predicted from milk traits with fertility in Japanese Holsteins
Authors: Nishiura Akiko , Sasaki Osamu , Yamazaki Takeshi , Yamaguchi Shigeki , Hagiya Koichi , Nakagawa Satoshi , Abe Hayato , Nakahori Yuka , Saito Yuriko , Tatebayashi Ryoki , Masuda Yutaka 
Published: July 2024

AbstractWe predicted the energy balance of cows from milk traits and estimated the genetic correlations of predicted energy balance (PEB) with fertility traits for the first three lactations. Data included 9,646,606 test‐day records of 576,555 Holstein cows in Japan from 2015 to 2019. Genetic parameters were estimated with a multiple‐trait model in which the records among lactation stages and parities were treated as separate traits. Fertility traits were conception rate at first insemination (CR), number of inseminations (NI), and days open (DO). Heritability estimates of PEB were 0.28–0.35 (first lactation), 0.15–0.29 (second), and 0.09–0.23 (third). Estimated genetic correlations among lactation stages were 0.85–1.00 (first lactation), 0.73–1.00 (second), and 0.64–1.00 (third). Estimated genetic correlations among parities were 0.82–0.96 (between first and second), 0.97–0.99 (second and third), and 0.69–0.92 (first and third). Estimated genetic correlations of PEB in early lactation with fertility were 0.04 to 0.19 for CR, −0.03 to −0.19 for NI, and −0.01 to −0.24 for DO. Genetic improvement of PEB is possible. Lower PEB in early lactation was associated with worse fertility, suggesting that improving PEB in early lactation may improve reproductive performance.
Altered desensitization and internalization patterns of rodent versus human glucose‐dependent insulinotropic polypeptide (GIP) receptors. An important drug discovery challenge
Authors: Gasbjerg Lærke Smidt , Rasmussen Rasmus Syberg , Dragan Adrian , Lindquist Peter , Melchiorsen Josefine Ulrikke , Stepniewski Tomasz Maciej , Schiellerup Sine , Tordrup Esther Karen , Gadgaard Sarina , Kizilkaya Hüsün Sheyma , Willems Sabine , Zhong Yi , Wang Yi , Wright Shane C. , Lauschke Volker M. , Hartmann Bolette , Holst Jens Juul , Selent Jana , Rosenkilde Mette Marie 
Published: July 2024

AbstractBackground and PurposeThe gut hormone glucose‐dependent insulinotropic polypeptide (GIP) signals via the GIP receptor (GIPR), resulting in postprandial potentiation of glucose‐stimulated insulin secretion. The translation of results from rodent studies to human studies has been challenged by the unexpected effects of GIPR‐targeting compounds. We, therefore, investigated the variation between species, focusing on GIPR desensitization and the role of the receptor C‐terminus.Experimental ApproachThe GIPR from humans, mice, rats, pigs, dogs and cats was studied in vitro for cognate ligand affinity, G protein activation (cAMP accumulation), recruitment of beta‐arrestin and internalization. Variants of the mouse, rat and human GIPRs with swapped C‐terminal tails were studied in parallel.Key ResultsThe human GIPR is more prone to internalization than rodent GIPRs. Despite similar agonist affinities and potencies for Gαs activation, especially, the mouse GIPR shows reduced receptor desensitization, internalization and beta‐arrestin recruitment. Using an enzyme‐stabilized, long‐acting GIP analogue, the species differences were even more pronounced. ‘Tail‐swapped’ human, rat and mouse GIPRs were all fully functional in their Gαs coupling, and the mouse GIPR regained internalization and beta‐arrestin 2 recruitment properties with the human tail. The human GIPR lost the ability to recruit beta‐arrestin 2 when its own C‐terminus was replaced by the rat or mouse tail.Conclusions and ImplicationsDesensitization of the human GIPR is dependent on the C‐terminal tail. The species‐dependent functionality of the C‐terminal tail and the different species‐dependent internalization patterns, especially between human and mouse GIPRs, are important factors influencing the preclinical evaluation of GIPR‐targeting therapeutic compounds.
Neutrophil migration participates in the side effect of recombinant human tissue plasminogen activator
Authors: Huang Yuyou , Han Ziping , Shen Tong , Zheng Yangmin , Yang Zhenhong , Fan Junfen , Wang Rongliang , Yan Feng , Tao Zhen , Luo Yumin , Liu Ping 
Published: July 2024

AbstractAimsIschemic stroke remains a challenge in medical research because of the limited treatment options. Recombinant human tissue plasminogen activator (rtPA) is the primary treatment for recanalization. However, nearly 50% of the patients experience complications that result in ineffective reperfusion. The precise factors contributing to ineffective reperfusion remain unclear; however, recent studies have suggested that immune cells, notably neutrophils, may influence the outcome of rtPA thrombolysis via mechanisms such as the formation of neutrophil extracellular traps. This study aimed to explore the nonthrombolytic effects of rtPA on neutrophils and highlight their contribution to ineffective reperfusion.MethodsWe evaluated the effects of rtPA treatment on middle cerebral artery occlusion in rats. We also assessed neutrophil infiltration and activation after rtPA treatment in vitro and in vivo in a small cohort of patients with massive cerebral ischemia (MCI).ResultsrtPA increased neutrophil infiltration into the brain microvessels and worsened blood–brain barrier damage during ischemia. It also increased the neutrophil counts of the patients with MCI.ConclusionNeutrophils play a crucial role in promoting ischemic injury and blood–brain barrier disruption, making them potential therapeutic targets.
Anticoagulation and Antiplatelet Regimen in Cardiac Transplant. Clinical Characteristics, Outcomes, and Blood Product Transfusion
Authors: Groba Marco Maria del Val , Saavedra Santana Pedro , Gonzalez del Castillo Luz Maria , Galvan Ruiz Mario , de Fernandez de Sanmamed Miguel , Urso Stefano , Guerra Hernández Elisabet , Quintana Paris Laura , Tout Castellano Michelle , Romero Lujan Jose Luis , Caballero Dorta Eduardo Jose , Guerra Dominguez Luisa Maria , Garcia Quintana Antonio 
Published: July 2024

ABSTRACTBackgroundWe aimed to evaluate the characteristics, clinical outcomes, and blood product transfusion (BPT) rates of patients undergoing cardiac transplant (CT) while receiving uninterrupted anticoagulation and antiplatelet therapy.MethodsA retrospective, single‐center, and observational study of adult patients who underwent CT was performed. Patients were classified into four groups: (1) patients without anticoagulation or antiplatelet therapy (control), (2) patients on antiplatelet therapy (AP), (3) patients on vitamin K antagonists (AVKs), and (4) patients on dabigatran (dabigatran). The primary endpoints were reoperation due to bleeding and perioperative BPT rates (packed red blood cells (PRBC), fresh frozen plasma, platelets). Secondary outcomes assessed included morbidity and mortality‐related events.ResultsOf the 55 patients included, 6 (11%) received no therapy (control), 8 (15%) received antiplatelet therapy, 15 (27%) were on AVKs, and 26 (47%) were on dabigatran. There were no significant differences in the need for reoperation or other secondary morbidity‐associated events. During surgery patients on dabigatran showed lower transfusion rates of PRBC (control 100%, AP 100%, AVKs 73%, dabigatran 50%, p = 0.011) and platelets (control 100%, AP 100%, AVKs 100%, dabigatran 69%, p = 0.019). The total intraoperative number of BPT was also the lowest in the dabigatran group (control 5.5 units, AP 5 units, AVKs 6 units, dabigatran 3 units; p = 0.038); receiving significantly less PRBC (control 2.5 units, AP 3 units, AVKs 2 units, dabigatran 0.5 units; p = 0.011). A Poisson multivariate analysis showed that only treatment on dabigatran reduces PRBC requirements during surgery, with an expected reduction of 64.5% (95% CI: 32.4%–81.4%).ConclusionsIn patients listed for CT requiring anticoagulation due to nonvalvular atrial fibrillation, the use of dabigatran and its reversal with idarucizumab significantly reduces intraoperative BPT demand.
Probability ogives for trends in stock biomass and fishing mortality from landings time series
Authors: Roa‐Ureta Ruben H. , Amorim Patrícia , Segurado Susana 
Published: July 2024

AbstractMost fisheries are conducted without any scientific knowledge about the size and productivity of the stocks that support them. This navigation in the dark in most fisheries is a major obstacle in making them sustainable sources of nutrition for people in general and income for fishers and other economic actors along supply chains. Fisheries that have not been assessed generally are data‐intermediate and data‐poor, the latter usually having annual time series of landings as the single piece of data available. A major effort in the last two decades has been directed toward developing ‘catch‐only’ stock assessment methods, although some of these methods have been tested and found deficient. Here we provide a novel approach to using annual landing time series as the single source of data to qualitatively judge the condition of un‐assessed stocks using frequentist cumulative probability ogives, both in terms of stock biomass and fishing mortality. A meta‐analysis of the FishSource database allowed us to infer statistical patterns from hundreds of assessed fisheries and thousands of annual landings, biomass, and fishing mortality observations. Four stock‐management types were considered separately in the analysis: short‐lived and others (mid‐ to long‐lived) stocks, controlled or not controlled by catch limits. Obtained cumulative probability ogives provide clear evaluations of stock biomass and fishing mortality trends in all four stock‐management types, leading to actionable information on probable current status and future trends. Using these probability ogives, we developed decision trees that lead to qualitative scores on the exploitation status of un‐assessed stocks.
Associations of E‐proteinoid 3 receptor genetic polymorphisms with salt sensitivity, longitudinal blood pressure changes, and hypertension incidence in Chinese adults
Authors: Chang Ming‐Ke , Wu Guan‐Ji , Bao Peng , Yao Shi , Du Ming‐Fei , Chu Chao , Wang Dan , Jia Hao , Sun Yue , Yan Yu , Zhang Xi , Hu Gui‐Lin , Man Zi‐Yue , Guo Tong‐Shuai , Luo Wen‐Jing , Li Hao , Wang Yang , Mu Jian‐Jun 
Published: July 2024

AbstractThe E‐proteinoid 3 receptor (PTGER3), a member of the prostaglandin E2 (PGE2) subtype receptor, belongs to the G‐protein‐coupled superfamily of receptors. Animal studies have demonstrated its involvement in salt sensitivity by regulating sodium reabsorption. This study aimed to investigate the association between genetic variants of PTGER3 and salt sensitivity, longitudinal blood pressure (BP) changes, and the incidence of hypertension in Chinese adults. A chronic salt intake intervention was conducted involving 514 adults from 124 families in the 2004 Baoji Salt‐Sensitivity Study Cohort in northern China. These participants followed a 3‐day regular baseline diet, followed by a 7‐day low‐salt diet (3.0 g/d) and a 7‐day high‐salt diet (18 g/d), and were subsequently followed for 14 years. The findings revealed a significant relationship between the single nucleotide polymorphism (SNP) rs17482751 of PTGER3 and diastolic blood pressure (DBP) response to high salt intervention. Additionally, SNPs rs11209733, rs3765894, and rs2268062 were significantly associated with longitudinal changes in systolic blood pressure (SBP), DBP, and mean arterial pressure (MAP) during the 14‐year follow‐up period. SNP rs6424414 was significantly associated with longitudinal changes in DBP over 14 years. Finally, SNP rs17482751 showed a significant correlation with the incidence of hypertension over 14 years. These results emphasize the significant role of PTGER3 gene polymorphism in salt sensitivity, longitudinal BP changes, and the development of hypertension in the Chinese population.
Prenatal diagnosis of the umbilical cord torsion at the placental cord insertion site: A case report and literature review
Authors: Hashiramoto Shin , Arakaki Tatsuya , Takita Hiroko , Kaneko Mayumi , Matsuoka Ryu , Sekizawa Akihiko 
Published: July 2024

AbstractA 35‐year‐old woman (gravida 1, para 0) was admitted to our hospital at 28 weeks' gestation with vaginal bleeding from placenta previa. Severe fetal bradycardia was observed during fetal heart rate monitoring. Ultrasonography showed widely dilated veins on the fetal surface of the placenta and an extraordinarily low umbilical artery peak systolic velocity in the Doppler study. Umbilical cord torsion was suspected. On the subsequent day, we performed a cesarean section due to worsening fetal heart rate patterns. Umbilical artery blood gas analysis indicated severe acidemia (pH 7.063), and umbilical cord torsion was confirmed at the placental cord insertion site. Diagnosing UCT prenatally is challenging; however, it can be suspected by scanning for the widely dilated veins on the fetal placental surface, termed as the “Sunset Sign,” an abnormally low umbilical artery peak systolic velocity, and other fetal Doppler abnormalities.
Attitude and experience of obstetricians and gynecologists toward eating disorders assessment and management in Japan: A nationwide survey
Authors: Ogawa Mariko , Komura Hiroko , Ono Yoko , Nose‐Ogura Sayaka , Kawai Keisuke , Terauchi Masakazu ,   from the subcommittee “Survey of the Obstetrics and Gynecology‐Based Treatment for Patients with Eating Disorders in Japan” in Women's Health Care Committee, Japan Society of Obstetrics and Gynecology, 2021–2022
Published: July 2024

AbstractAimTo investigate the attitudes and experiences of obstetricians and gynecologists in treating women with eating disorders (EDs) in Japan.MethodsMembers of the Japan Society of Obstetrics and Gynecology were invited to participate in a web‐based survey from March 1 to 31, 2022. We asked about the attitudes of obstetricians and gynecologists toward women with weight loss‐related amenorrhea and their experiences in treating EDs. We also assessed the characteristics of physicians who see many ED patients.ResultsA total of 662 ob/gyns. responded to the survey. While treating weight loss‐related amenorrhea, 25.8% reported screening patients for EDs. 88.5% of respondents reported having treated ED patients. The main medical concerns described when treating pregnant women with ED were fetal growth restriction and preterm delivery. The most common type of ED encountered by participants in both perinatal and infertility care settings was anorexia nervosa. Characteristics of physicians who treated 10 or more EDs per year were being board certified in women's health care and not providing delivery services (OR = 4.809, 1.896). The most common comment regarding optimizing the management of patients with EDs in obstetrics and gynecology practice was the need to implement guidelines for ED management.ConclusionsMany obstetricians and gynecologists in Japan treat patients with ED. Standardized guidelines for the management of EDs for obstetricians and gynecologists are needed.