bluuebunny/crossref_metadata_2025_split huggingface dataset:
Untangling the Mistral and Seasonal Atmospheric Forcing Driving Deep Convection in the Gulf of Lion: 1993–2013
Authors: Keller Douglas , Givon Yonatan , Pennel Romain , Raveh‐Rubin Shira , Drobinski Philippe 
Published: July 2024

AbstractDeep convection occurs periodically in the Gulf of Lion, in the northwestern Mediterranean Sea, driven by the seasonal atmospheric change and Mistral winds. To determine the variability and drivers of both forcings, multiple 1 year ocean simulations were run, spanning from 1993 to 2013. Two sets of simulations were performed: a control and seasonal set, the first forced by unfiltered atmospheric forcing and the other by filtered forcing. The filtered forcing was bandpass filtered, retaining the seasonal and intraday aspects but removing the high frequency phenomena. Comparing the two sets allows for distinguishing the effects of the high frequency component of the Mistral on the ocean response. During the preconditioning phase, the seasonal forcing was found to be the main destratifying process, removing on average 46% of the stratification needed for deep convection to occur, versus the 28% removed by the Mistral. Despite this, each forcing triggered deep convection in roughly half of the deep‐convection events. Sensible and latent heat fluxes were found to be the main drivers of the seasonal forcing during deep‐convection years, removing 0.17 and 0.43 m2s−2 of stratification, respectively. They were themselves driven by increased wind speeds, believed to be the low frequency signal of the Mistral, as more Mistral events occur during deep‐convection winters (34% vs. 29% of the preconditioning period days). An evolving seasonal forcing in a changing climate may have significant effects on the future deep convection cycle of the western Mediterranean Sea.
Tropical Sea Surface Temperature Variability and Its Impact on Oilseed Crop Yields in China
Authors: Zhou Yi , Zhang Tianyi , Li Xichen 
Published: July 2024

AbstractUnderstanding how climate variability affects oilseed yields is crucial for ensuring a stable oil supply in regions such as China, where self‐sufficiency in edible vegetable oils is low. Here, we found coherent patterns in the interannual variability of Sea Surface Temperature (SST) anomalies and percent crop yield anomalies in the three ocean basins, and then quantified the contribution of these SST modes to oilseed crop yield anomalies. Our analysis revealed that, at the national level, the six tropical SST modes collectively accounted for 51% of soybean, 52% of rapeseed, and 33% of peanut yield anomalies in China. Tropical Indian Ocean variability exerts the greatest impact on soybean and peanut yield variability, whereas the most significant impact on rapeseed yield anomalies is attributed to El Niño‐Southern Oscillation. Finally, this study examined the specific ways in which changes in SST modes can affect oilseed crop yields using changes in local meteorological variables. Our findings revealed the relationship between tropical SST variability and oilseed crop yields, providing a detailed understanding of the diverse connections between SST modes and oilseed crop yield. This study deepens our knowledge of the influence of climate variability on agriculture, offering valuable insights for devising strategies to mitigate the adverse effects of climate variability on oilseed crop production in China.
Methane Emissions From Seabed to Atmosphere in Polar Oceans Revealed by Direct Methane Flux Measurements
Authors: Workman Evelyn , Fisher Rebecca E. , France James L. , Linse Katrin , Yang Mingxi , Bell Thomas , Dong Yuanxu , Jones Anna E. 
Published: July 2024

AbstractSea‐air methane flux was measured directly by the eddy‐covariance method across approximately 60,000 km of Arctic and Antarctic cruises during a number of summers. The Arctic Ocean (north of 60°N, between 20°W and 50°E) and Southern Ocean (south of 50°S, between 70°W and 30°E) are found to be on‐shelf sources of atmospheric methane with mean sea‐air fluxes of 9.17 ± 2.91 (SEM (standard error of the mean)) μmol m−2 d−1 and 8.98 ± 0.91 μmol m−2 d−1, respectively. Off‐shelf, this region of the Arctic Ocean is found to be a source of methane (mean flux of 2.39 ± 0.68 μmol m−2 d−1), while this region of the Southern Ocean is found to be a methane sink (mean flux of −0.77 ± 0.37 μmol m−2 d−1). The highest fluxes observed are found around west Svalbard, South Georgia, and South Shetland Islands and Bransfield Strait; areas with evidence of the presence of methane flares emanating from the seabed. Hence, this study may provide evidence of direct emission of seabed methane to the atmosphere in both the Arctic and Antarctic. Comparing with previous studies, the results of this study may indicate an increase in sea‐air flux of methane in areas with seafloor seepage over timescales of several decades. As climate change exacerbates rising water temperatures, continued monitoring of methane release from polar oceans into the future is crucial.
Planetary‐Scale Wave Activity in Venus Cloud Layer Simulated by the Venus PCM
Authors: Lai Dexin , Lebonnois Sebastien , Li Tao 
Published: July 2024

AbstractThe Venus atmosphere Superrotation (SR) is successfully simulated with the high‐resolution (1.25° × 1.25° in longitude and latitude) runs of the Venus Planetary Climate Model (PCM). The results show a clear spectrum and structure of atmospheric waves, primarily with periods of 5.65 and 8.5 days. The simulation reproduces long‐term quasi‐periodic oscillation of the zonal wind and primary planetary‐scale wave seen in observations. These oscillations occur with a period of 163–222 days, although their existence is still debated in observations. The Rossby waves show similarity in wave characteristics and angular momentum (AM) transport due to Rossby‐Kelvin instability by comparing the 5.65‐day wave in Venus PCM with the 5.8‐day wave simulated by AFES‐Venus, another Venus General Circulation Model. Similarities are also evident between the 8.5‐day wave in Venus PCM and the 7‐day wave obtained in AFES‐Venus. The long‐term variations in the AM budget indicate that the 5.65‐day wave is the dominant factor of the oscillation on the SR, and the 8.5‐day wave plays a secondary role. When the 5.65‐day wave grows, its AM and heat transport are enhanced and accelerate (decelerate) the lower‐cloud equatorial jet (cloud‐top mid‐latitude jets). Meanwhile, the 8.5‐day wave weakens, reducing its deceleration effect on the lower‐cloud equator. This further suppresses the meridional gradient of the background wind and weakens instability, leading to the decay of the 5.65‐day wave. And vice versa when the 5.65‐day wave decays.
Variability of the Bottom Boundary Layer Induced by the Dynamics of the Cross‐Isobath Transport Over a Variable Shelf
Authors: Cheng Weicong , Gan Jianping 
Published: July 2024

AbstractThe bottom boundary layer (BBL) dynamics play an important role in regulating the energy, momentum balance, and circulation in the shallow shelf areas. Unlike previous studies that disconnected BBL with background variable shelf circulation, we investigate the dynamic connection between the wind‐driven shelf circulation and BBL dynamics, and show the spatial characteristics of BBL dynamics in response to three‐dimensional (3D) heterogeneous transport over the highly variable shelf topography in the Northern South China Sea. Our process‐oriented modeling study demonstrates that the mixing dynamics and upslope buoyancy transport over varying shelf topography alter the spatial variability of BBL dynamics. Driven by southwesterly upwelling‐favorable winds, the along‐shelf current generated a frictional upslope Ekman transport. The along‐isobath pressure gradient force () formed by the flow‐topography interactions over the meandering shelf induces the geostrophic cross‐isobath transport. The downwave (upwave) enhances (offset) the frictional upslope transport over the east (west) of the shelf that has a concaving (uniform) bottom topography. Over the eastern shelf with concave isobaths, the intensified and upslope cross‐isobath dense water transport strengthen stratification and weaken the effect of bottom stress‐induced mixing, limiting the development of the BBL. The antithesis occurs over the western shelf, where a small bottom stress controls the BBL. River discharge and the tidal current modulate the alongshore current, upslope transport, bottom stress intensity, and BBL development. We model the trajectory of seabed particles as they respond to the BBL dynamic regimes, and find that high (low) concentration, short (long) suspension time, and strong (weak) shoreward transport occurover the eastern (western) shelf, respectively.
Cell competition in primary and metastatic colorectal cancer
Authors: van Luyk Merel Elise , Krotenberg Garcia Ana , Lamprou Maria , Suijkerbuijk Saskia Jacoba Elisabeth 
Published: July 2024

AbstractAdult tissues set the scene for a continuous battle between cells, where a comparison of cellular fitness results in the elimination of weaker “loser” cells. This phenomenon, named cell competition, is beneficial for tissue integrity and homeostasis. In fact, cell competition plays a crucial role in tumor suppression, through elimination of early malignant cells, as part of Epithelial Defense Against Cancer. However, it is increasingly apparent that cell competition doubles as a tumor-promoting mechanism. The comparative nature of cell competition means that mutational background, proliferation rate and polarity all factor in to determine the outcome of these processes. In this review, we explore the intricate and context-dependent involvement of cell competition in homeostasis and regeneration, as well as during initiation and progression of primary and metastasized colorectal cancer. We provide a comprehensive overview of molecular and cellular mechanisms governing cell competition and its parallels with regeneration.
CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation
Authors: Quintanal-Villalonga Alvaro , Kawasaki Kenta , Redin Esther , Uddin Fathema , Rakhade Swanand , Durani Vidushi , Sabet Amin , Shafer Moniquetta , Karthaus Wouter R. , Zaidi Samir , Zhan Yingqian A. , Manoj Parvathy , Sridhar Harsha , Kinyua Dennis , Zhong Hong , Mello Barbara P. , Ciampricotti Metamia , Bhanot Umesh K. , Linkov Irina , Qiu Juan , Patel Radhika A. , Morrissey Colm , Mehta Sanjoy , Barnes Jesse , Haffner Michael C. , Socci Nicholas D. , Koche Richard P. , de Stanchina Elisa , Molina-Pinelo Sonia , Salehi Sohrab , Yu Helena A. , Chan Joseph M. , Rudin Charles M. 
Published: July 2024

AbstractNeuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53 (TP53) and Retinoblastoma Transcriptional Corepressor 1 (RB1) mutations in their tumors, no therapeutic strategies are available to prevent or delay histological transformation. Upregulation of the cell cycle kinase Cell Division Cycle 7 (CDC7) occurred in tumors during the initial steps of NE transformation, already after TP53/RB1 co-inactivation, leading to induced sensitivity to the CDC7 inhibitor simurosertib. CDC7 inhibition suppressed NE transdifferentiation and extended response to targeted therapy in in vivo models of NE transformation by inducing the proteasome-mediated degradation of the MYC Proto-Oncogen (MYC), implicated in stemness and histological transformation. Ectopic overexpression of a degradation-resistant MYC isoform reestablished the NE transformation phenotype observed on targeted therapy, even in the presence of simurosertib. CDC7 inhibition also markedly extended response to standard cytotoxics (cisplatin, irinotecan) in lung and prostate small cell carcinoma models. These results nominate CDC7 inhibition as a therapeutic strategy to constrain lineage plasticity, as well as to effectively treat NE tumors de novo or after transformation. As simurosertib clinical efficacy trials are ongoing, this concept could be readily translated for patients at risk of transformation.
GLUT1 inhibitor BAY-876 induces apoptosis and enhances anti-cancer effects of bitter receptor agonists in head and neck squamous carcinoma cells
Authors: Miller Zoey A. , Muthuswami Sahil , Mueller Arielle , Ma Ray Z. , Sywanycz Sarah M. , Naik Anusha , Huang Lily , Brody Robert M. , Diab Ahmed , Carey Ryan M. , Lee Robert J. 
Published: July 2024

AbstractHead and neck squamous cell carcinomas (HNSCCs) are cancers that arise in the mucosa of the upper aerodigestive tract. The five-year patient survival rate is ~50%. Treatment includes surgery, radiation, and/or chemotherapy and is associated with lasting effects even when successful in irradicating the disease. New molecular targets and therapies must be identified to improve outcomes for HNSCC patients. We recently identified bitter taste receptors (taste family 2 receptors, or T2Rs) as a novel candidate family of receptors that activate apoptosis in HNSCC cells through mitochondrial Ca2+ overload and depolarization. We hypothesized that targeting another component of tumor cell metabolism, namely glycolysis, may increase the efficacy of T2R-directed therapies. GLUT1 (SLC2A1) is a facilitated-diffusion glucose transporter expressed by many cancer cells to fuel their increased rates of glycolysis. GLUT1 is already being investigated as a possible cancer target, but studies in HNSCCs are limited. Examination of immortalized HNSCC cells, patient samples, and The Cancer Genome Atlas revealed high expression of GLUT1 and upregulation in some patient tumor samples. HNSCC cells and tumor tissue express GLUT1 on the plasma membrane and within the cytoplasm (perinuclear, likely co-localized with the Golgi apparatus). We investigated the effects of a recently developed small molecule inhibitor of GLUT1, BAY-876. This compound decreased HNSCC glucose uptake, viability, and metabolism and induced apoptosis. Moreover, BAY-876 had enhanced effects on apoptosis when combined at low concentrations with T2R bitter taste receptor agonists. Notably, BAY-876 also decreased TNFα-induced IL-8 production, indicating an additional mechanism of possible tumor-suppressive effects. Our study demonstrates that targeting GLUT1 via BAY-876 to kill HNSCC cells, particularly in combination with T2R agonists, is a potential novel treatment strategy worth exploring further in future translational studies.
Investigation of a novel PROS1 splicing variant in a patient with protein S deficiency
Authors: Niida Yo , Fujita Wataru , Togi Sumihito , Ura Hiroki 
Published: July 2024

Abstract
Here, we report a novel PROS1 splicing mutation in a patient with type I protein S deficiency. Qualitative and quantitative analysis of pathogenic splicing variants at the mRNA level was performed by long-range PCR-based targeted DNA and RNA sequencing. A base substitution in the exon 4 splicing donor site activates a potential splicing donor site in intron 4, resulting in an in-frame insertion of 48 bases (16 amino acids).
Origami-inspired soft fluidic actuation for minimally invasive large-area electrocorticography
Authors: Coles Lawrence , Ventrella Domenico , Carnicer-Lombarte Alejandro , Elmi Alberto , Troughton Joe G. , Mariello Massimo , El Hadwe Salim , Woodington Ben J. , Bacci Maria L. , Malliaras George G. , Barone Damiano G. , Proctor Christopher M. 
Published: July 2024

AbstractElectrocorticography is an established neural interfacing technique wherein an array of electrodes enables large-area recording from the cortical surface. Electrocorticography is commonly used for seizure mapping however the implantation of large-area electrocorticography arrays is a highly invasive procedure, requiring a craniotomy larger than the implant area to place the device. In this work, flexible thin-film electrode arrays are combined with concepts from soft robotics, to realize a large-area electrocorticography device that can change shape via integrated fluidic actuators. We show that the 32-electrode device can be packaged using origami-inspired folding into a compressed state and implanted through a small burr-hole craniotomy, then expanded on the surface of the brain for large-area cortical coverage. The implantation, expansion, and recording functionality of the device is confirmed in-vitro and in porcine in-vivo models. The integration of shape actuation into neural implants provides a clinically viable pathway to realize large-area neural interfaces via minimally invasive surgical techniques.
Trans-membrane piezoelectric activation of peroxymonosulfate for effective control of waterborne antibiotic resistance dissemination
Authors: Yu Yang , Liu Lianyu , Xie Yiqiao , Huang Wei , Liu Hai , Liu Xiaotu , Chen Da 
Published: July 2024

AbstractIncreasing prevalence of antibiotic resistant bacteria (ARB) and antibiotic resistance genes (ARGs) constitutes an emerging water safety issue globally. However, the effectiveness of current water treatment techniques in the control of ARGs dissemination remains controversial. Here, we develop a dual-zone strategy based on piezoelectric membrane filtration to efficiently eliminate waterborne antibiotic resistance. Following complete ARB inactivation and effective ARGs reduction in the retentate near the membrane surface (zone 1), a subsequent trans-membrane process (zone 2) further promotes ARGs elimination in the permeate, due to boosted interactions between ARGs and reactive oxygen species (ROS) generated from piezoelectric peroxymonosulfate activation and minimized ROS competition from inactivated ARB within piezocatalytic channels. The abundance of ARGs was largely reduced to ~1.0 × 103 copies·mL−1 in the permeate from ~5.0 × 106 copies·mL−1 in the feed solution. The singlet oxygen (1O2) is demonstrated to be primarily responsible for ARB inactivation, while 1O2, hydroxyl radical (•OH), sulfate radical (SO4·−) and superoxide radical (·O2−) can all participate in ARGs degradation. Our work demonstrates that the piezoelectric membrane-based dual-zone strategy has great potential to control the risk of ARGs dissemination.
Decadal increases in carbon uptake offset by respiratory losses across northern permafrost ecosystems
Authors: See Craig R. , Virkkala Anna-Maria , Natali Susan M. , Rogers Brendan M. , Mauritz Marguerite , Biasi Christina , Bokhorst Stef , Boike Julia , Bret-Harte M. Syndonia , Celis Gerardo , Chae Namyi , Christensen Torben R. , Murner Sara June , Dengel Sigrid , Dolman Han , Edgar Colin W. , Elberling Bo , Emmerton Craig A. , Euskirchen Eugénie S. , Göckede Mathias , Grelle Achim , Heffernan Liam , Helbig Manuel , Holl David , Humphreys Elyn , Iwata Hiroki , Järveoja Järvi , Kobayashi Hideki , Kochendorfer John , Kolari Pasi , Kotani Ayumi , Kutzbach Lars , Kwon Min Jung , Lathrop Emma R. , López-Blanco Efrén , Mammarella Ivan , Marushchak Maija E. , Mastepanov Mikhail , Matsuura Yojiro , Merbold Lutz , Meyer Gesa , Minions Christina , Nilsson Mats B. , Nojeim Julia , Oberbauer Steven F. , Olefeldt David , Park Sang-Jong , Parmentier Frans-Jan W. , Peichl Matthias , Peter Darcy , Petrov Roman , Poyatos Rafael , Prokushkin Anatoly S. , Quinton William , Rodenhizer Heidi , Sachs Torsten , Savage Kathleen , Schulze Christopher , Sjögersten Sofie , Sonnentag Oliver , St. Louis Vincent L. , Torn Margaret S. , Tuittila Eeva-Stiina , Ueyama Masahito , Varlagin Andrej , Voigt Carolina , Watts Jennifer D. , Zona Donatella , Zyryanov Viacheslav I. , Schuur Edward A. G. 
Published: July 2024

AbstractTundra and boreal ecosystems encompass the northern circumpolar permafrost region and are experiencing rapid environmental change with important implications for the global carbon (C) budget. We analysed multi-decadal time series containing 302 annual estimates of carbon dioxide (CO2) flux across 70 permafrost and non-permafrost ecosystems, and 672 estimates of summer CO2 flux across 181 ecosystems. We find an increase in the annual CO2 sink across non-permafrost ecosystems but not permafrost ecosystems, despite similar increases in summer uptake. Thus, recent non-growing-season CO2 losses have substantially impacted the CO2 balance of permafrost ecosystems. Furthermore, analysis of interannual variability reveals warmer summers amplify the C cycle (increase productivity and respiration) at putatively nitrogen-limited sites and at sites less reliant on summer precipitation for water use. Our findings suggest that water and nutrient availability will be important predictors of the C-cycle response of these ecosystems to future warming.
Modelling Salmonella Typhi in high-density urban Blantyre neighbourhood, Malawi, using point pattern methods
Authors: Khaki Jessie J. , Meiring James E. , Thindwa Deus , Henrion Marc Y. R. , Jere Tikhala M. , Msuku Harrison ,   The STRATAA Consortium, Aryja Amit , Maharjan Archana , Dongol Sabina , Karkey Abhilasha , Bajracharya Binod Lal , Banda David , Masesa Clemens , Mbewe Maurice , Mangulenji George , Msefula Chisomo , Nyirenda Tonney , Mujadidi Yama F. , Voysey Merryn , Hill Jennifer , Gurung Pallavi , Khan Arifuzzaman , Saha Nirod Chandra , Biswas Prasanta Kumar , Adhikari Anup ,   the Nepal Family Development Foundation team, Heyderman Robert S. , Gordon Melita A. , Giorgi Emanuele 
Published: July 2024

AbstractSalmonellaTyphi is a human-restricted pathogen that is transmitted by the faecal–oral route and causative organism of typhoid fever. Using health facility data from 2016 to 2020, this study focuses on modelling the spatial variation in typhoid risk in Ndirande township in Blantyre. To pursue this objective, we developed a marked inhomogeneous Poisson process model that allows us to incorporate both individual-level and environmental risk factors. The results from our analysis indicate that typhoid cases are spatially clustered, with the incidence decreasing by 54% for a unit increase in the water, sanitation, and hygiene (WASH) score. Typhoid intensity was also higher in children aged below 18 years than in adults. However, our results did not show evidence of a strong temporal variation in typhoid incidence. We also discuss the inferential benefits of using point pattern models to characterise the spatial variation in typhoid risk and outline possible extensions of the proposed modelling framework.