bluuebunny/crossref_metadata_2025_split huggingface dataset:
Abstract B12: Recruitment of African American breast cancer pedigrees for The Jewels in Our Genes Study: Recruitment outcomes and sample characteristics
Authors: Wang Youjin , Erwin Deborah O. , Jandorf Lina , Johnson Detric , Meadows-Ray Veronica , Willis Mattye , Ochs-Balcom Heather 
Published: May 2015

Abstract
Background. Few studies have investigated the contribution of inherited genetic variation to breast cancer disparities and fewer have examined whether risk alleles shared in families may contribute to higher risk of aggressive tumors. One barrier is the challenge of effectively recruiting African American families for research.
Methods. Using a community-based participatory research (CBPR) orientation, we utilized multi-level methods in an iterative fashion to recruit for a breast cancer genetic linkage study. We recruited affected relative pairs as well as discordant sibling pairs where possible. We analyzed our recruitment yield by method and calculated descriptive statistics for several demographic and clinical characteristics of families selected for genotyping, which includes 281 individuals from 106 pedigrees (197 affecteds, 84 unaffecteds).
Results. We recruited 341 African American women (247 with breast cancer and 94 unaffecteds) from 127 families. The top three yields were obtained via collaboration with the Love Army of Women (34% of sample), The National Witness Project (NWP, 29% of sample), and previous epidemiologic studies (24% of sample). Within the set of 106 pedigrees selected for genotyping, 27 pedigrees have one affected relative, 68 pedigrees have 2 affecteds, 10 pedigrees have 3 affecteds, and one pedigree has 6 affecteds. Where adjudicated (n=141, 72%), the mean and median age at diagnosis was 51.6 years (SD 12.0) and 51.6 years, respectively. Affected women were younger at menarche (p=0.002) and more likely to be hysterectomized (p=0.018) compared to unaffected women. According to tumor receptor status, approximately 26% of cases are ER negative, 40% are PR negative, 49% are HER2 negative, and overall 16% are ER/PR/HER2 negative.
Conclusions. Approaching recruitment of African American pedigrees with use of a multi-pronged approach that includes collaboration from the community can greatly facilitate success. While our sample has a slightly younger age of onset compared to African American cases in the general population (SEER median age for African Americans is 58 yrs), the sample approximates the US proportion of all invasive breast cancers in the US with regard to triple negative status (∼15%).
Citation Format: Youjin Wang, Deborah O. Erwin, Lina Jandorf, Detric Johnson, Veronica Meadows-Ray, Mattye Willis, Heather Ochs-Balcom. Recruitment of African American breast cancer pedigrees for The Jewels in Our Genes Study: Recruitment outcomes and sample characteristics. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr B12. doi:10.1158/1538-7755.DISP13-B12
Abstract C28: An exploratory study of co-occurrence of breast cancer and diabetes in medically underserved Latinas
Authors: Ashing Kimlin T. , Rosales Monica , Samoa Raynald , Lai Lily , Vargas Roberto , Vito Courtney , Hurria Arti , Serrano Mayra 
Published: May 2015

Abstract
Purpose: Cancer and diabetes are two severe chronic illnesses that often co-occur. The presence of diabetes in cancer patients is associated with increased risk for poor health outcomes and decreased overall survival. Lack of access to care and under-diagnosis of diabetes makes this co-occurrence particularly troubling among the Latino population. This preliminary study explored the association of diabetes with functioning and physical health outcomes among underserved Latina breast cancer survivors (BCS).
Methods: In total, 137 low income Latina BCS were recruited from the California Cancer Registry, hospital cancer registries, and community agencies. Latina BCS completed a self-report questionnaire that assessed demographic and cancer-related medial characteristics, the co-occurrence of diabetes, and functional and physical outcomes.
Results: Among Latina BCS, 98 (72%) were non-diabetic and 39 (28 %) were diabetic. Latina BCS with diabetes were more likely to report less than a high school education, being uninsured, and unemployed (p&lt;0.01), and more likely to report later stage at diagnosis than BCS without diabetes. BCS with diabetes reported more lymphedema symptoms than BCS without diabetes (p&lt;0.05). Although not statistically significant, BCS with diabetes had lower general health, experienced more pain, and reported greater social functioning and physical role limitations than BCS without diabetes.
Conclusions: This preliminary investigation sheds new light on emerging evidence documenting the negative associations of comorbid chronic conditions such as diabetes on patients' outcomes. More attention to the co-occurrence of cancer and chronic disease is warranted for addressing cancer health disparities. Our descriptive analysis offers support for additional inquiry and attention to the co-occurrence of cancer and chronic disease as a target for action in improvements in quality, patient-centered care and in the reduction of persistent health disparities.
Citation Format: Kimlin T. Ashing, Monica Rosales, Raynald Samoa, Lily Lai, Roberto Vargas, Courtney Vito, Arti Hurria, Mayra Serrano. An exploratory study of co-occurrence of breast cancer and diabetes in medically underserved Latinas. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C28. doi:10.1158/1538-7755.DISP13-C28
Abstract C36: Psychosocial outcomes in cancer survivors treated at a comprehensive cancer center or a minority-serving institution
Authors: Friedman Debra L. , Sanderson Maureen , Hull Pamela , Wujcik Debra , Ashworth Dira R. , Okafor Amaka , Kennedy Jane , Hill Paula , Shen-Miller David 
Published: May 2015

Abstract
Background: Cancer health disparities are well described for incidence, diagnosis and treatment. Little is known about disparities among long-term survivors.
Methods: At Vanderbilt-Ingram Cancer Center (VICC), an NCI-designated comprehensive cancer center and Meharry Medical College (MMC), minority serving institutional partner, we evaluated quality of life (QOL) using the FACT-G, FACT-B, FACT-L, and FACT-P; posttraumatic stress disorder (PTSD) using the PTSD Checklist (PCL); and posttraumatic growth (PTG) using the PTG Inventory (PTGI) among breast, lung or prostate cancer survivors. We used linear regression to compare the scale mean values by institution while adjusting for confounding variables.
Results: Among 111 breast, 53 lung and 68 prostate cancer survivors, mean age was 62 years, 61% were female, 33% were black, 65% were married, 22% and 67% respectively had a high school degree or some college/higher education, 36% were employed and 94% were insured. MMC survivors were younger (p = 0.0005), more likely to be black (p &lt;0.0001), less likely to be married (p &lt; 0.0001), less educated (p&lt;0.0001) and more likely to be uninsured (p &lt; 0.0001). After adjusting for race, insurance status and educational level, there were no significant differences in cancer-related QOL between VICC and MMC survivors. MMC survivors did score significantly higher than VICC survivors on the PCL (33.9 vs. 28.3; p = 0.01) and the PTGI (75.9 vs. 62.5; p = 0.002). A total of 19 (8.3%) survivors met criteria for PTSD with a score of 50 or more (18.1% MMC, 3.8% VICC, p =0.003). Scores were significantly increased for MMC survivors relative to VICC survivors on all PTG subscales, especially the appreciation for life subscale (p = 0.0005).
Conclusion: Cancer health disparities extend into the survivorship period. Although overall QOL did not differ, survivors treated at an underserved institution had significantly higher PTSD than those treated at a comprehensive cancer center. Underserved survivors also exhibited higher degrees of PTG. Further evaluation will identify the most significant sources of stress and resilience in order to design interventions to improve psychosocial wellbeing and decrease disparities.
Citation Format: Debra L. Friedman, Maureen Sanderson, Pamela Hull, Debra Wujcik, Dira R. Ashworth, Amaka Okafor, Jane Kennedy, Paula Hill, David Shen-Miller. Psychosocial outcomes in cancer survivors treated at a comprehensive cancer center or a minority-serving institution. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C36. doi:10.1158/1538-7755.DISP13-C36
Abstract C37: “Oh happy day”: A pilot study of a culturally tailored depression intervention for African American female cancer survivors
Authors: Williams Elizabeth A. , Ward Earlise , Wujcik Debra , Oatis-Ballew Robin , Green Cheryl , Gunter Navita , Bond Brea 
Published: May 2015

Abstract
Almost 1 million African Americans are now identified as cancer survivors. Despite this growth, African Americans' long-term survivorship lags behind national survival rates. Given that cancer survivorship starts with diagnosis and continues throughout life, improving cancer survival outcomes for African Americans is important. Cancer survivors are at increased risk of experiencing psychosocial distress and depression as a result of cancer. Because of discrimination and multiple systemic barriers, African American cancer survivors may not have access to high quality healthcare treatment and services nor seek services in mainstream facilities. Thus their survivorship, including access to high quality, culturally competent behavioral health supports, may be compromised.
While current research suggests racial and cultural differences in cancer experiences, coping strategies and survivorship among different racial/ethnic groups, little is known about effective behavioral health resources African American female cancer survivors use to cope with depression. Even less is known about culturally tailored interventions that could potentially aid African American female cancer survivors by reducing depressive symptoms and supporting improved mental health.
A Culturally Tailored Depression Intervention for African American Female Cancer Survivors Study, a community-engaged research project attempts to determine the feasibility of a culturally tailored depression intervention called “Oh Happy Day Class.” Using group therapy and psycho-educational supports, including yoga, this study determines whether a 4-week modified version of this class, offered in a community setting, is acceptable to African American female cancer survivors. The class, coupled with other mixed methods (surveys, key informant interviews) provides important information about the benefits of offering culturally tailored depression interventions for African American female cancer survivors. As a community-engaged research project including African American female cancer survivors, Public Health researchers, & health professionals, this study further underscores why engaging community in the work of supporting cancer survivorship for African Americans is needed.
Citation Format: Elizabeth A. Williams, Earlise Ward, Debra Wujcik, Robin Oatis-Ballew, Cheryl Green, Navita Gunter, Brea Bond. “Oh happy day”: A pilot study of a culturally tailored depression intervention for African American female cancer survivors. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C37. doi:10.1158/1538-7755.DISP13-C37
Abstract C54: Reducing time-to-treatment in underserved Latinas with breast cancer: The Six Cities Study
Authors: Ramirez Amelie G. , Perez-Stable Eliseo J. , Penedo Frank , Talavera Gregory A. , Carillo J. Emilio , Fernandez Maria F. , Holden Alan E.C. , Munoz Edgar , Gallion Kipling 
Published: May 2015

Abstract
Background: Breast cancer is the leading cause of Latina cancer deaths. Time from diagnosis to treatment is critical in optimizing care. Patient navigation (PN) holds promise for timely breast cancer treatment promotion, yet efficacy among underserved women is insufficiently documented.
Methods: Redes En Acción: The National Latino Cancer Research Network evaluated a theory-driven, culturally-sensitive PN program for Latinas with breast cancer in six U.S. cities. We analyzed 109 Latinas diagnosed with breast cancer from July 2008-January 2011 (42 navigated, 67 controls). We evaluated proportions of women treated within 30 and 60 days of diagnosis and overall time to treatment. Women were navigated by locally trained navigators, or non-navigated. Kaplan-Meier, Cox proportional hazards and logistic regression models were used to determine group differences.
Results: A higher percentage of navigated subjects initiated treatment within 30 days (66.7% versus 56.7%, p=0.045) and 60 days (97.8% versus 78.4%, p=0.021). Overall navigated women experienced shorter time to treatment initiation (HR=1.60, p=0.000). These results were independent of stage at diagnosis, cancer clinic and participant characteristics. Five navigator activities were associated with faster treatment times: accompaniment (p=0.006), transportation arrangements (p=0.013), patient telephone support (generally emotional support, p=0.034), patient-family telephone support (p=0.030), and Spanish-English language translation services (p=0.002).
Conclusions: Patient-centered navigation to assist Latina women with breast cancer diagnoses increases the proportion of women beginning treatment within 30 and 60 days of diagnosis and significantly reduces overall time from diagnosis to treatment. Improvement appears to be associated with specific navigator activities.
Citation Format: Amelie G. Ramirez, Eliseo J. Perez-Stable, Frank Penedo, Gregory A. Talavera, J. Emilio Carillo, Maria F. Fernandez, Alan E.C. Holden, Edgar Munoz, Kipling Gallion. Reducing time-to-treatment in underserved Latinas with breast cancer: The Six Cities Study. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C54. doi:10.1158/1538-7755.DISP13-C54
Abstract C55: Racial disparities in receipt of initial prostate cancer treatment, SEER Medicare, 2004-2009
Authors: Richards Thomas B. , Negoita Serban , McNeel Timothy S. , Li Jun , Li Chunyu 
Published: May 2015

Abstract
Purpose: Prostate cancer death rates are higher in blacks than whites. Using the Surveillance, Epidemiology and End Results (SEER)-Medicare linked database, we evaluated whether racial disparities exist in the receipt of initial prostate cancer treatment.
Methods: We analyzed data on prostate cancer cases diagnosed in 2004-2009 and linked with Medicare claims data from 2003-2010. We focused on cases with SEER race coded as white or black; and enrolled in both Medicare Parts A and B continuously during 12 months before diagnosis to 24 months after diagnosis, death, or December 2010, whichever was earliest. We defined prostate cancer recurrence risk categories using tumor stage, prostate specific antigen (PSA), and Gleason scores. We identified initial prostate cancer treatment using: radical prostatectomy, radiation therapy, or androgen deprivation therapy within 1 month before to 6 months after diagnosis; or evidence of active surveillance based on prostate biopsies or PSA tests from 1 to 18 months after diagnosis. We used multivariate logistic regression to determine adjusted odds ratios (OR) and 95% confidence intervals (CI). The outcome variable was receipt of initial treatment. Explanatory variables were: race; prostate cancer disease recurrence risk category; asymptomatic or symptomatic at time of first diagnosis; life expectancy from the man's age at diagnosis; comorbidity; census tract poverty; and census region.
Results: Our final study cohort included 70,254 white men and 8,653 black men with prostate cancer. After adjustment for multiple variables, men were less likely to receive initial treatment if: expected survival &lt; 5 years (OR, 0.36; 95% CI, 0.33–0.40; ref.= &gt; 10 years); black race (OR, 0.54; 95% CI, 0.50–0.57; ref. = white); or symptomatic at time of diagnosis (OR, 0.77, 95% CI, 0.74–0.81; ref.=asymptomatic). Men were more likely to receive initial treatment if: high recurrence risk (OR, 2.75; 95% CI, 2.55–2.96; ref.= low); resided in Northeast (OR, 1.30; 95% CI 1.24–1.38; ref.= West); comorbidity score &gt; 2 (OR, 1.24; 95% CI, 1.17–1.31; ref. = 0); or lived in a census tract with &lt;5% poverty (OR, 1.14; 95% CI, 1.07–1.22; ref.= &gt; 19%).
Conclusion: Low expected survival and black race were relatively important reasons that older men did not receive initial treatment for prostate cancer.
Citation Format: Thomas B. Richards, Serban Negoita, Timothy S. McNeel, Jun Li, Chunyu Li. Racial disparities in receipt of initial prostate cancer treatment, SEER Medicare, 2004-2009. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C55. doi:10.1158/1538-7755.DISP13-C55
Abstract C75: Unique SPOP somatic mutations in African American prostate cancer
Authors: Buckles Eric L. , Qian Chiping , Majumdar Sumana , Zabaleta Jovanny , Liu Wanguo 
Published: May 2015

Abstract
SPOP (Speckle-type POZ protein) is a tumor suppressor in prostate cancer (PCa). Somatic heterozygous missense mutations in SPOP have been reported in up to 15% of PCa in Caucasian American (CA). However, the mutation frequency and the genetic role of SPOP in African American (AA) PCa are currently unknown. We sequenced exons 6 and 7 of the SPOP gene for somatic mutations in 49 AA prostate tumor tissues collected in the Southern Louisiana area and identified five (10%) tumors carrying heterozygous missense mutations and one tumor carrying a novel synonymous variant. Intriguingly, all mutations are clustered in exon 6 and change conserved amino acids. Moreover, three mutations represent novel mutations and unique to AA PCa. To further identify unique SPOP somatic mutations in AA PCa, we expanded mutation screening to all of the other exons of the SPOP gene but no additional coding variant or deletion/insertion was identified. Quantitative RT-PCR analysis indicates that the SPOP mutations in AA prostate tumors reduced SPOP RNA levels in tumors compared with SPOP levels in their adjacent normal prostate tissues; therefore, supporting the notion of SPOP as a tumor suppressor gene. These results indicate that AA prostate tumors carry similar frequency but a unique profile of SPOP somatic mutations as in Caucasian PCa. The clinical relevance and the pathological significance of SPOP mutations in AA PCa will be discussed.
Citation Format: Eric L. Buckles, Chiping Qian, Sumana Majumdar, Jovanny Zabaleta, Wanguo Liu. Unique SPOP somatic mutations in African American prostate cancer. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C75. doi:10.1158/1538-7755.DISP13-C75
Abstract C83: Health status and chronic conditions of biracial Asians in California 2001-2009
Authors: Nguyen Anh B. , Breen Nancy , Clark Trenette T. , Moser Richard 
Published: May 2015

Abstract
Intro: In 2000, 6.8 million individuals identified with two or more races. This number increased to over 9 million by 2010, representing a 30% increase within a span of 10 years. The rapid growth of racial and ethnic minority populations in the US will transform the cultural milieu and engender shifts in health, economic, social, and political landscapes. These shifts necessitate the examination of health profiles of these emerging populations to determine whether they experience disparate health behaviors or outcomes in comparison to their monoracial counterparts. The focus of the present study was to examine health outcomes and chronic conditions for the biracial Asian population in California. We hypothesized that the biracial population will display intermediate (or an “average” of) outcomes in comparison to their monoracial counterparts.
Methods: This study utilized merged data from respondents (N = 238,897) to iterations of the California Health Interview Survey (CHIS) administered in 2001, 2003, 2005, 2007, and 2009. After adjusting for sociodemographic variables, we ran multivariable regression models to predict health outcomes (i.e., diabetes, heart disease, high blood pressure, disability status, BMI, and general health) and to compare health outcomes among various racial and ethnic groups.
Results: After adjusting for relevant covariates, multivariate results revealed that Whites reported better health overall than biracial Asians and other monoracial groups. For example, Whites were less likely to report having been diagnosed with diabetes, high blood pressure, and physical disability, and had higher perceived general health than biracial Asians and other monoracial individuals. We also found that biracial Asians displayed BMI ranges that were intermediate between their monoracial constituents.
Conclusions: BMI is a more proximal health outcome and is more sensitive to lifestyles and behaviors. As a result, BMI may be a better indicator that biracial Asians have indeed adopted health behaviors and practices that fall between their monoracial counterparts. Future epidemiological research should examine the prevalence of more proximal health outcomes among biracial Asians and assess how it differs by developmental age. Additional studies should also examine how health behaviors among biracial Asians change over time and are associated with chronic medical conditions.
Citation Format: Anh B. Nguyen, Nancy Breen, Trenette T. Clark, Richard Moser. Health status and chronic conditions of biracial Asians in California 2001-2009. [abstract]. In: Proceedings of the Sixth AACR Conference: The Science of Cancer Health Disparities; Dec 6–9, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2014;23(11 Suppl):Abstract nr C83. doi:10.1158/1538-7755.DISP13-C83