bluuebunny/crossref_metadata_2025_split huggingface dataset:
Gigatonnes Missing Biomass Energy Consumption in Rural China
Authors: Wu Shimei , Han Xiao , Li Chuan-Zhong , Löschel Andreas , Lu Xi , Du Limin , Zheng Xinye , Wei Chu 
Published: August 2024

To provide a more comprehensive reconstruction of China’s energy consumption, this paper built a machine-learning-based geospatial model that shows great accuracy in recovering historical biomass consumption data using the household survey dataset for China, combined with province-level characteristics and spatiotemporal information. Our study suggested that 6.9 ± 2.6 giga-tons of coal equivalent of biomass were uncounted in China’s statistics, representing 15.9 ± 6.0 percent for China and 2.5 ± 0.9 percent for global final energy consumption. This new estimate significantly reshaped our understanding of China’s energy composition, sectoral mix, indoor air pollutants, and the factors driving energy consumption. These findings provide a replicable template for developing countries hoping to uncover the biomass demand to better design public policy to achieve Sustainable Development Goals. JEL Classification: Q41, Q53, R12, C81, O13
Acute kidney injury as a prognostic predictor of in-hospital mortality and neurological outcomes in patients after extracorporeal cardiopulmonary resuscitation
Authors: Kim Dong Ki , Cho Yong Soo , Lee Byung Kook , Jeung Kyung Woon , Jung Yong Hun , Lee Dong Hun , Kim Min Chul , Jeong In Seok , Chun Byeong Jo , Moon Jeong Mi 
Published: August 2024

Introduction Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly being applied to patients with refractory cardiac arrest, but the survival rate to hospital discharge is only approximately 29%. Because ECPR requires intensive resources, it is important to predict outcomes. We therefore investigated the prognostic association between acute kidney injury (AKI) and ECPR to confirm the performance of AKI as a prognostic predictor of in-hospital mortality and neurological outcomes in ECPR. Methods We conducted a retrospective observational study on patients undergoing ECPR for cardiac etiology at Chonnam National University Hospital from 2015 to 2021. The group diagnosed with AKI in any KDIGO category within the first 48 h after ECPR was compared to that without AKI, and the primary outcome of the study was in-hospital mortality. Results Of 138 enrolled patients, 83 were studied. Hospital mortality occurred in 49 patients (59%), and 55 (66.3%) showed poor neurological outcomes. The AKI group displayed significantly elevated in-hospital mortality (77.8% vs 24.1%) and poor neurological outcomes (81.5% vs 37.9%) compared to the non-AKI group ( p < 0.001). Regression analysis showed that AKI was associated with significantly higher rates of both in-hospital mortality (odds ratio (OR) range 10.75-12.88) and neurologic outcomes (OR range 5.9–6.22). Conclusions There was a significant association of AKI with both in-hospital mortality and poor neurologic outcome in patients after ECPR, and AKI can be used as an early prognostic predictor in these patients.
Evidence-based guidelines for the interpretation of the 9-item Concise Health Risk Tracking – Self-Report (CHRT-SR9) measure of suicidal risk
Authors: Nandy Karabi , Nandy Rajesh Ranjan , Rush A John , Mayes Taryn L , Trivedi Madhukar H 
Published: August 2024

Background: The 9-item Concise Health Risk Tracking – Self-Report (CHRT-SR9) is a widely used patient-reported outcome measure of suicidal risk. The goal of this article is to provide an evidence-based interpretation of the CHRT-SR9 total score in terms of four clinically actionable categories of suicidal risk (none, mild, moderate, and severe). Methods: Data from two large programs involving adolescents and adults were combined in this paper. In these studies, the CHRT-SR9 was anchored against an independent measure of suicidal risk, the suicide item (Item #9) in the Patient Health Questionnaire (PHQ-9), with categories 0 (none), 1 (mild), 2 (moderate), and 3 (severe). In the combined data ( n = 1945), we calculated the cumulative percentage of data across these four categories and the percentile score of the CHRT-SR9 total score that corresponded to these percentages; from this, we developed ranges of the CHRT-SR9 total score that corresponded to the four categories of Item #9 of PHQ-9. We also calculated similar ranges for two broad subscales of the CHRT-SR9 total score; Propensity and Suicidal Thoughts. To assess the robustness of our findings, we repeated the analysis at another timepoint across studies. Results: Findings indicated that the CHRT-SR9 total score (range: 0–36) can be categorized as none (0–14), mild (15–21), moderate (22–26), and severe (27–36). Similar categories were calculated for the Propensity and Suicidal Thoughts subscales. The findings were the same when repeated at another timepoint. Conclusion: This categorization of the CHRT-SR9 total score can place patients into clinically meaningful and actionable categories of suicidal risk.
Combining bioinformatics, network pharmacology and artificial intelligence to predict the target genes of S-ketamine for treating major depressive disorder
Authors: Xianjin Zhou , Fuyi Shen , Ti Yang , Shan Li , Kang Zhao , Ying Wang , Shengqiong Deng 
Published: August 2024

Background: Ketamine has received attention owing to its rapid and long-lasting antidepressant effects; however, its clinical application is restricted by its addictiveness and adverse effects. S-ketamine, which is the S-enantiomer of ketamine, is considered safer and better tolerated by patients than ketamine. Aims: This study aimed to identify the key gene targets and potential signalling pathways associated with the mechanism of S-ketamine in major depressive disorder (MDD) treatment. Methods: The GSE98793 dataset was extracted from the Gene Expression Omnibus database, and differentially expressed genes were identified in blood samples from patients with MDD and healthy individuals. The hub genes among the differentially expressed genes were identified and enrichment analysis was performed. The therapeutic targets and related signalling pathways of S-ketamine in MDD treatment were analysed. The 3D structures of the target proteins were predicted using AlphaFold2, and molecular docking was performed to verify whether S-ketamine could be successfully docked to the predicted targets. A quantitative polymerase chain reaction was performed to determine the effect of ketamine on the screened targets. Among 228 target genes annotated using pharmacophore target gene analysis, 3 genes were identified and 2 therapeutic signalling pathways were discovered. Results: S-ketamine exerts downregulatory effects on TGM2 and HSP90AB1 expression but exerts an up-regulatory effect on ADORA3 expression. The protein structures of the therapeutic targets were successfully predicted using AlphaFold2. Conclusions: S-ketamine may alleviate depression by targeting specific genes, including TGM2, HSP90AB1 and ADORA3, as well as signalling pathways, including the gonadotropin-releasing hormone and relaxin signalling pathways.
Impact of childhood adversity on acute subjective effects of stimulant and opioid drugs: Evidence from placebo-controlled studies in healthy volunteers
Authors: Carlyle Molly , de Wit Harriet , Leknes Siri 
Published: August 2024

Background and Aims: Early-life adversities are known to alter drug reward processing in rodents. Despite the well-known link between early adversity and the risk of substance use disorder, few studies have measured how childhood adversity affects human drug reward. Here, we assessed the relationship between historical childhood adversities and responses to single doses of methamphetamine, d-amphetamine or buprenorphine in healthy participants. Methods: Using a secondary analysis approach, we assessed the impact of childhood adversity on drug effects from three randomised, placebo-controlled studies in which healthy volunteers received methamphetamine (20 mg oral; n = 35), d-amphetamine (20 mg oral; n = 54) or buprenorphine (0.2 mg sublingual; n = 35). Ratings of feeling effect, liking, disliking, feeling high and wanting more of the drug were collected 15–210 min post-administration, and heart rate changes were analysed using random-intercept mixed-effect models. The area under the curve from these and previous studies was calculated to visualise the relationship between childhood adversity severity and drug effects. Results: Greater childhood adversity was associated with reduced feel effects (significant three-way interactions b = −0.07, 95% CI [−0.12, −0.02], p = 0.009), like effects ( b = −0.07, 95% CI [−0.13, −0.00], p = 0.038) and feel high ( b = −0.06, 95% CI [−0.10, −0.01], p = 0.020) towards the stimulant drugs 90–180 min post-administration. Conclusions: Childhood adversity was not significantly associated with other subjective or heart rate responses to the drugs. Overall, participants with more childhood adversities reported dampened subjective responses to stimulant drugs, but not to buprenorphine. Future studies should examine the generalisability of these relationships, to identify the mechanisms underlying the link between childhood adversity and drug responsiveness.
“It's a Thing”: What Nurse Elders Believe Novice Nurses Need to Know About Managing Emotional Labour
Authors: Ross Charlotte A. 
Published: August 2024

Background Emotional labour (EL) can take a significant toll on nurses’ mental health and well-being and has serious implications for the retention of nurses in the workforce. Nurse educators have struggled to prepare novices to manage EL or find serviceable resources with which to do so within the body of nursing literature, which is dominated by essentially unhelpful narratives and is absent of the practical, real-world wisdom of elder nurses. Purpose This exploratory research study illuminated elder nurses’ experiential knowledge and beliefs of what is important for novices to learn about EL. Methods Conventional Content Analysis (CCA) of qualitative survey data from 688 nurses with 20+ years of experience. Results CCA generated descriptive categories and sub-categories: What the elders themselves learned as student nurses, and their advice to novices in the individual realm, (“It's a Thing,” healthy disengagement, supporting mental and physical well-being, reframing self-reproach), team realm (peer support, mentors), and institutional realm (structural barriers to mentors’ support of novices, building novices’ capacities for self-advocacy, resources to support health and well-being). Conclusions The elders’ data confronted and reframed legacy individuated narratives in the literature by supporting and contextualizing nurses’ emotional work. Elders advised novices that EL is a reality requiring concrete strategies to manage it throughout their practices. Elders extended their focus for management of EL beyond the individual to include peer support, mentorship, and the structural conditions in which nurses perform their EL, highlighting the need to empower nurses by building their capacity for self-advocacy of their workers’ rights.
UV and outdoor weathering of glass fiber reinforced polycarbonate/acrylonitrile-butadiene-styrene composites and recycling of aged composites
Authors: Kuram Emel , Ozcelik Babur , Kocoglu Hurol , Ayas Hamza , Dogan Mehmet 
Published: August 2024

Polymeric materials usage is rising, and they are exposed to some effects such as temperature, light, water throughout their lifetime. Increase in use of polymer has led to waste problems. From an environmental point of view, recycling (reprocessing) of polymers is one of the viable solutions to diminish waste issues. Thus, in this work, the effect of reprocessing for aged glass fiber reinforced polycarbonate/acrylonitrile-butadiene-styrene (PC/ABS) composites having different glass fiber content was determined on the mechanical properties (tensile, impact, flexural), melt flow index and morphology. Virgin glass fiber reinforced PC/ABS specimens were exposed to two environments, namely artificial accelerated ageing in a QUV chamber for up to 336 h and natural ageing in Gebze (Turkey) for up to 1 year between January 2018 and January 2019 to determine the influence of a long-term outdoor exposure on the properties. After these ageing steps, naturally and UV aged specimens were ground and the ground specimens were mixed with virgin glass fiber reinforced PC/ABS at ratios of 25%, 50% and 75% by weight. The mixed materials were re-molded to fabricate test specimens and then characterized. In brief, in current research, the mechanical, rheological, and morphological properties of virgin, aged in outdoors for 12 months, aged in UV chamber for 336 h and blends of virgin-aged glass fiber reinforced PC/ABS composites were studied. Because there is no research regarding natural and UV ageing of PC/ABS having different glass fiber content, this study represents an important contribution to determining behavior of these composites after ageing. From experimental study, in general, it was found that mechanical properties decreased with natural and UV ageing, but some retention in properties could be achieved with the incorporation of pure polymer.
Tofacitinib versus thalidomide for mucocutaneous lesions of systemic lupus erythematosus: A real-world CSTAR cohort study XXVII
Authors: Zhao Man , Ma Leyao , Duan Xinwang , Huo Yuehong , Liu Shengyun , Zhao Cheng , Zheng Zhaohui , Wang Qian , Tian Xinping , Chen Yunzhuan , Li Mengtao 
Published: August 2024

Objective Thalidomide is an effective medication for refractory mucocutaneous lesions of systemic lupus erythematosus (SLE) and can treat arthritis in some autoimmune diseases, but it has some adverse reactions. Recently, the effectiveness of tofacitinib in treating mucocutaneous lesions of SLE has been reported. We aimed to compare the efficacy and safety of tofacitinib with thalidomide in treating mucocutaneous and musculoskeletal lesions in patients with SLE. Methods This study was a real-world cohort study based on the Chinese SLE Treatment and Research group (CSTAR) registry. SLE patients who manifested mucocutaneous and/or musculoskeletal symptoms and were prescribed tofacitinib or thalidomide were included. We retrospectively conducted comparisons between the tofacitinib and thalidomide groups regarding clinical improvements, SLE disease activity, serological indicators, glucocorticoid doses, and adverse events at the 1, 3, and 6-months time points. Results At 3 and 6 months, the tofacitinib group exhibited a higher proportion of patients with improvement in mucocutaneous and musculoskeletal issues. Additionally, a greater percentage of patients in the tofacitinib group achieved remission or a low disease activity state (LLDAS) at these time points. No significant serological improvements were observed in either the tofacitinib or thalidomide groups. Fewer adverse events were observed in the tofacitinib group than in the thalidomide group. Conclusions Tofacitinib might be superior to thalidomide in the improvement of mucocutaneous and musculoskeletal lesions in SLE, and had a good safety profile.
Evaluation of thyroid dysfunction in childhood-onset systemic lupus erythematosus: Risk factors for Hashimoto’s thyroiditis
Authors: Konte Elif Kilic , Karakas Hasan , Akay Nergis , Gul Umit , Ucak Kubra , Tarcin Gurkan , Aslan Esma , Gunalp Aybuke , Haslak Fatih , Turan Oya Koker , Yildiz Mehmet , Turan Hande , Ucar Ayse Kalyoncu , Adrovic Amra , Barut Kenan , Evliyaoglu Olcay , Sahin Sezgin , Kasapcopur Ozgur 
Published: August 2024

Objective Increased frequency of autoimmune thyroid disease, particularly Hashimoto’s thyroiditis (HT) was reported several studies in the literature, in individuals with childhood-onset systemic lupus erythematosus (cSLE). Our study aimed to investigate the prevalence and contributing factors of thyroid dysfunction and HT among cSLE patients. Methods Thyroid function tests were obtained cross-sectionally from cSLE patients. Demographic, clinical, and laboratory characteristics and activity scores were collected from medical records. Patients diagnosed with cSLE were compared to the healthy control group for the frequency of thyroid dysfunction. The Mann-Whitney U, independent samples t test, and the Chi-square or Fisher’s exact test were used to compare study groups. A p-value below 0.05 was considered statistically significant. Results Out of 73 cSLE patients, 14 (19.1%) had subclinical hypothyroidism, 9 (12.3%) had clinical hypothyroidism, 12 (16.4%) were diagnosed with HT, and 12 (16.4%) had a family history of HT. Thyroid USG was performed in 5 euthyroid patients and 1 borderline subclinical hypothyroid patient with positive thyroid autoantibody and reported as diffuse heterogeneous echogenicity enlargement in the thyroid gland. There were no significant differences in clinical and laboratory data or medication used between the groups with and without HT; however, patients with HT had a higher frequency of clinical hypothyroidism and family history of HT. Cumulative prednisolone dose was significantly lower in patients diagnosed with HT. The frequency of HT was considerably higher in patients with cSLE compared to the healthy control group. Conclusion The results demonstrate an increased incidence of HT in cSLE patients, even if they are euthyroid, and recommend that cSLE patients be screened more frequently.
Investigating physical inactivity and associated health parameters in patients with systemic lupus erythematosus
Authors: Sari Fulden , Pala Gamze Gülsün , Oskay Deran , Tufan Abdurrahman 
Published: August 2024

Background Physical inactivity, which is highly prevalent in patients with systemic lupus erythematosus (SLE), is an independent risk factor for cardiovascular events and causes many complications. This study aimed to investigate the effect of objective measurement and physical activity level on peripheral muscle strength, exercise capacity, pain, dyspnea, fatigue, anxiety, and depression in patients with SLE. Methods The present cross-sectional study analyzed 41 patients with SLE. Clinical and demographic characteristics of patients were recorded. Functional exercise capacity, peripheral muscle strength, dyspnea, pain, fatigue, anxiety, and depression were assessed. The physical activity level was assessed by a wearable activity tracker (Mi Band four smart band). Results The number of steps measured by the activity tracker was 4384.43 ± 1558.21 steps per day in patients with SLE. Patients with physical activity levels below 5000 steps exhibited elevated levels of fatigue, along with diminished functional exercise capacity and knee muscle strength, in comparison to those who were above the 5000-step threshold. Physical activity levels correlated with functional exercise capacity (6MWT), physiological parameters (maximum heart rate, Δ heart rate, Δ dyspnea, QFM fatigue, Δ QFM fatigue), and knee extension muscle strength. The functional exercise capacity and knee extension were identified as significantly and dependently associated with physical activity levels in SLE patients. Conclusion Physical activity level is associated with functional exercise capacity and knee muscle strength in patients with SLE.
A Retrospective Analysis of the Efficacy of Oral Dexamethasone in Combination With Docetaxel Plus Ramucirumab Therapy for Previously Treated Lung Cancer
Authors: Hamai Kosuke , Katsura Ryo , Miyake Shinya , Fujita Suguru , Tada Shinpei , Hirakawa Tetsu , Ueno Sayaka , Tanimoto Takuya , Ishikawa Nobuhisa 
Published: August 2024

Introduction Docetaxel plus ramucirumab (DTX + RAM) therapy is a standard treatment for previously treated lung cancer, but many adverse events have been reported. This retrospective study was conducted to examine if the side effects of DTX + RAM therapy can be minimized by the combined use of oral dexamethasone (DEX), and to assess the therapeutic effect of DTX + RAM in patients with recurrent lung cancer. Methods Forty patients with relapsed non-small cell lung cancer who underwent DTX + RAM therapy were divided into two groups based on the concomitant use of oral DEX, and the therapeutic effects and toxicities in the two groups were compared. Results The objective response rate (ORR) was significantly better in the DEX group ( P = 0.0203). The median progression-free survival (PFS) was 5.20 months vs 2.87 months ( P = 0.064) in the DEX and non-DEX groups, respectively. However, the median overall survival (OS) was significantly better in the DEX group (15.17 months vs 7.37 months, P = 0.0317). The frequency of fluid retention within six months of the start of treatment was 10.0% vs 42.5% in the DEX and non-DEX groups, respectively, with the fluid retention rate being significantly higher in the non-DEX group ( P = 0.039). Conclusion Concomitant use of oral DEX during DTX + RAM therapy may facilitate the long-term continuation of treatment and contribute to OS prolongation.
US cat caregivers’ attitudes on veterinary video telemedicine
Authors: Lee Sooyoung , Boone Grace , Bidgoli Ashley , Di Bernardo Joshua , Moody Carly M 
Published: August 2024

ObjectivesMany cats do not see a veterinarian on an annual basis, and their caregivers face many barriers to accessing veterinary care. A potential solution to overcome some of these barriers is video telemedicine. Thus, the aim of this study was to understand companion cat caregivers’ perceptions of using veterinary video telemedicine with their cats.MethodsAn online quantitative questionnaire was used to survey US cat caregivers on their experiences of and attitudes to using video telemedicine with their cats. Participants were required to reside in the USA, be the primary caregiver of at least one cat and be aged 18 years or older.ResultsThe majority (97.3%) of the 1254 respondents indicated they had never used a video telemedicine appointment with their cat(s) before; however, most (85.7%) indicated they were very or somewhat interested in using video telemedicine with their cat. Overall, caregivers perceived video telemedicine visits as less stressful for themselves ( P <0.0002) and their cats ( P <0.0001), and as increasing their access to veterinary care ( P <0.0001) compared with in-clinic visits. Participants also indicated they would prefer a video telemedicine appointment over an in-clinic appointment for most cat behavioral concerns but preferred in-clinic appointments for most health concerns. Most respondents (51.3%) indicated they would be willing to pay a little less for a telemedicine appointment than an in-clinic visit.Conclusions and relevanceCat caregivers represent an important population that could benefit from the implementation of video telemedicine into veterinary care. Our results suggest many US cat caregivers indicate an interest and willingness to pay for video telemedicine visits to increase their access to veterinary care and reduce stress associated with veterinary visits for both themselves and their cats. Caregivers showed more interest in using video telemedicine for behavioral concerns than health concerns.