bluuebunny/crossref_metadata_2025_split huggingface dataset:
The “appearing” and “disappearing” ascites in the treatment of colorectal cancer: a case report
Authors: Cui Hong-Ming , Shu Xin-Peng , Wei Zheng-Qiang , Wu Xing-Ye 
Published: June 2024

BackgroundColorectal cancer (CRC) is one of the most common cancers worldwide. In the treatment of patients with CRC, oxaliplatin plays a pivotal role, with moderate side effects. Neurotoxicity, myelosuppression, ototoxicity, delayed hypersensitivity reactions, and rhabdomyolysis induced by oxaliplatin have been reported individually. However, the occurrence of oxaliplatin-induced ascites has not been reported previously. The objectives of this case report were to elaborate on the rare occurrence of ascites in a patient with CRC after oxaliplatin therapy and to explore its characteristics and causes.Case descriptionWe report on a case of upper rectal cancer seen in a 65-year-old man who underwent robotic-assisted laparoscopic anterior rectal resection. The patient developed ascites during postoperative adjuvant therapy with oxaliplatin and capecitabine. We ruled out tumor recurrence by laparoscopy, intraoperative biopsy, and biochemistry of the ascites. The patient did not experience a recurrence of ascites after discontinuation of chemotherapy.ConclusionThis case suggests that chemotherapy with oxaliplatin might cause ascites. The mechanism of the oxaliplatin-induced liver injury was further discussed, which might have been the cause of ascite formation. When patients with CRC who underwent chemotherapy with oxaliplatin develop ascites, surgeons should actively determine whether this is a side effect of chemotherapy or is due to tumor recurrence in order to avoid unnecessary surgery.
A combination of risk stratification systems for thyroid nodules and cervical lymph nodes may improve the diagnosis and management of thyroid nodules
Authors: Xu Cong-Ying , Yu Jing , Cui Yi-Yang , Huang Yuan-Jing , Fu Chao , Cui Ke-Fei 
Published: June 2024

IntroductionTo assess the performance of the European Thyroid Association Thyroid Imaging and Reporting Data System (EU-TIRADS) and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS), which combine risk stratification systems for thyroid nodules (TN-RSS) and cervical lymph nodes (LN-RSS) in diagnosing malignant and metastatic thyroid cancer in a single referral center.MethodsWe retrospectively analyzed 2,055 consecutive patients who underwent thyroidectomy or fine-needle aspiration (FNA) from January 2021 to December 2022. TNs and LNs were categorized according to the ultrasonography (US) features of EU-TIRADS and K-TIRADS, respectively. The diagnostic performance and postponed malignancy rate (PMR) were compared with those of EU-TIRADS and K-TIRADS. PMR was defined as the number of patients with malignant nodules not recommended for biopsy among patients with cervical LN metastasis.ResultsAccording to the EU-TIRADS and K-TIRADS, for TN-RSS alone, there were no significant differences in sensitivity, specificity, accuracy, unnecessary FNA rate (UFR), missed malignancy rate (MMR), and PMR between the two TIRADSs (29.0% vs. 28.8%, 50.5% vs. 51.1%, 32.3% vs. 32.2%, 23.6% vs. 23.5%, 88.6% vs. 88.5%, and 54.2% vs. 54.5%, P &gt; 0.05 for all). Combining the LN-RSS increased the diagnostic accuracy (42.7% vs. 32.3% in EU-TIRADS; 38.8% vs. 32.2% in K-TIRADS) and decreased the PMR (54.2% vs. 33.9% in EU-TIRADS; 54.5% vs. 39.3% in K-TIRADS). EU-TIRADS had higher sensitivity and accuracy and lower PMR than K-TIRADS (41.3% vs. 36.7%, 42.7% vs. 38.8%,33.9% vs. 39.3%, P &lt; 0.05 for all).ConclusionsA combination of TN-RSS and LN-RSS for the management of thyroid nodules may be associated with a reduction in PMR, with enhanced sensitivity and accuracy for thyroid cancers in EU-TIRADS and K-TIRADS. These results may offer a new direction for the detection of aggressive thyroid cancers.
Naoxintong capsule for treating cardiovascular and cerebrovascular diseases: from bench to bedside
Authors: Zhang Wei-jian , Chen Rui-qi , Tang Xuan , Li Pei-bo , Wang Jian , Wu Hai-ke , Xu Ning , Zou Ming-fei , Luo Sen-rong , Ouyang Zi-qi , Chen Zhi-kai , Liao Xu-xing , Wu Hao 
Published: June 2024

Naoxintong Capsule (NXT), a renowned traditional Chinese medicine (TCM) formulation, has been broadly applied in China for more than 30 years. Over decades, accumulating evidences have proven satisfactory efficacy and safety of NXT in treating cardiovascular and cerebrovascular diseases (CCVD). Studies have been conducted unceasingly, while this growing latest knowledge of NXT has not yet been interpreted properly and summarized comprehensively. Hence, we systematically review the advancements in NXT research, from its chemical constituents, quality control, pharmacokinetics, to its profound pharmacological activities as well as its clinical applications in CCVD. Moreover, we further propose specific challenges for its future perspectives: 1) to precisely clarify bioactivities of single compound in complicated mixtures; 2) to evaluate the pharmacokinetic behaviors of NXT feature components in clinical studies, especially drug-drug interactions in CCVD patients; 3) to explore and validate its multi-target mechanisms by integrating multi-omics technologies; 4) to re-evaluate the safety and efficacy of NXT by carrying out large-scale, multicenter randomized controlled trials. In brief, this review aims to straighten out a paradigm for TCM modernization, which help to contribute NXT as a piece of Chinese Wisdom into the advanced intervention strategy for CCVD therapy.
El deficiente desarrollo microempresarial en la ciudad de Loja, Ecuador
Authors: Vallejo Ramírez Jorge Baltazar , Villalta Villalta Jhesica Katerine , Aguilar Lima Mayerli de los Ángeles 
Published: June 2024

El deficiente desarrollo microempresarial en la ciudad de Loja es uno de los principales problemas que se han presentado en el ámbito económico, financiero y social, es por ello que en el presente artículo se da a conocer como es el desarrollo microempresarial y su relación con los factores sociales y económicos, dado que actualmente se muestran estadísticas donde ciudad de Loja representa el 3,2 % del total de las microempresas en el Ecuador, considerándose como un porcentaje muy por debajo de la media obtenida y presentada por otras ciudades, razón por la cual se muestran las causas y efectos de la carencia de desarrollo microempresarial y sus repercusiones en la economía local. Los resultados obtenidos revelan que la carencia de desarrollo microempresarial se da por algunos aspectos como: la desorganización social o aislamiento del individuo, ubicación geográfica, fracaso y rentabilidad microempresarial, insuficiencia del capital y la ausencia de tener una buena planificación. Finalmente, se menciona que existen factores que frena el desarrollo microempresarial en Loja que limitan su crecimiento económico y social
Epidemiology, Risk Factors, and Clinical Outcomes of AKI in Pediatric Hematopoietic Stem Cell Transplant Patients
Authors: Ashruf Omer S. , Ashruf Zaid , Orozco Zara , Zinter Matt , Abu-Arja Rolla , Yerigeri Keval , Haq Imad U. , Kaelber David C. , Bissler John , Raina Rupesh 
Published: June 2024

Key Points

The cumulative incidence of AKI diagnosis post–hematopoietic stem cell transplantation was 12.9%. Calcineurin inhibitor use was associated with the highest cumulative incidence, 21.6%, after hematopoietic stem cell transplantation.Patients with AKI with hypertension/hypertensive disease had a 30-day survival probability of 63.9% (hazard ratio, 4.86, 95% confidence interval, 3.58 to 6.60).Patients with AKI were 2.5 times more likely to experience composite hospitalization and/or mortality at 30 days. Of patients who developed AKI, dialysis dependence has nearly tripled since 2014.

Background
AKI is a common complication in pediatric patients undergoing hematopoietic stem cell transplantation (HSCT), with a reported prevalence ranging from 68% to 84%. Few multicenter pediatric studies comprehensively assess the epidemiologic associations and clinical outcomes associated with AKI development.

Methods
An observational, retrospective analysis was conducted using an aggregated electronic health record data platform. The study population consisted of pediatric patients (age <18 years) who underwent HSCT over a 20-year period. The study groups consisted of patients with an encounter diagnosis of AKI (n=713) and those without AKI (n=4455). Both groups were propensity matched for age, sex, race, prior cancer diagnosis, and other comorbidities. End points were incidence, mortality risk, clinical outcomes, and prevalence of dialysis dependence. Competing risks analysis, Cox proportional hazard analyses, Kaplan–Meier survival curves, and incidence/prevalence rates were calculated.

Results
After matching, 688 patients were identified. Cumulative incidence of AKI diagnosis post-HSCT was 13.7%. Hypertensive disease, calcineurin inhibitors, and vancomycin were the most prevalent risk factors for AKI, with calcineurin inhibitors showing the highest cumulative incidence (21.6%). Patients with AKI with hypertensive disease had a survival probability of 63.9% at 30 days, followed by calcineurin inhibitors (64.4%) and vancomycin (65.9%). Patients with AKI were 1.7 times more likely to experience composite hospitalization and/or mortality at 30 days. At 365 days post-HSCT, patients with AKI had higher rates of all-cause emergency department visits, intensive care unit admissions, and mechanical ventilation compared with non-AKI. Of patients who developed AKI, the prevalence of dialysis dependence has nearly tripled since 2014.

Conclusions
The findings highlight a strong association between specific risk factors, such as hypertension, calcineurin inhibitor use, and vancomycin use, with increased mortality and adverse clinical outcomes in patients with AKI after HSCT. These results emphasize the need for preventative actions such as 24-hour BP monitoring and discontinuation of potential nephrotoxic medications.
Menelusuri Etika Bermasyarakat: Analisis Perspektif Wahbah Al-Zuhaili dalam Kitab Al-Tafsir Al-Munir Fi Al-Aqidah, Al-Shari’ah, dan Al-Manhaj
Authors: Shohib Muhammad 
Published: June 2024

<p>Studi ini bertujuan untuk memahami pandangan Wahbah Al-Zuhaili tentang etika sosial dalam Islam, termasuk nilai-nilai, prinsip-prinsip, dan pedoman perilaku yang diperlukan untuk membangun masyarakat yang beradab dan harmonis. Melalui analisis mendalam terhadap kitab monumentalnya, "al-Tafsir al-Munir fi al-Aqidah, al-Shari'ah, dan al-Manhaj", penelitian ini untuk menguraikan pemikiran Al-Zuhaili tentang etika bermasyarakat. Penelitian ini merupakan sebuah studi pustaka yang menggunakan pendekatan kualitatif. Metode yang digunakan adalah metode tafsir tematik, yang merupakan suatu cara untuk menafsirkan Al-Qur’an dengan mengidentifikasi dan mengumpulkan ayat-ayat yang berkaitan dengan tema tertentu, kemudian menjelaskan maknanya secara terperinci serta menghubungkannya satu sama lain untuk membentuk suatu pemahaman komprehensif tentang pandangan Al-Qur’an terhadap tema tersebut. Dalam Al-Qur'an, etika bermasyarakat disampaikan secara konseptual tanpa disebutkan secara langsung. Ayat-ayat yang dianalisis oleh peneliti berdasarkan pemikiran Wahbah al-Zuhaili dalam kitab tafsir al-Munir. Ayat-ayat yang diperinci adalah sebagai berikut: QS. An-Nisa’ 4: 36, mengenai anjuran untuk berbuat baik kepada tetangga, baik yang dekat maupun yang jauh, menurut Imam Wahbah. QS. Al-Kahf 18: 77, mengenai keutamaan menjamu tamu, diinterpretasikan oleh Imam Wahbah sebagai kewajiban bagi tuan rumah untuk memberi makan kepada tamu.QS. Al-Anfal 8: 61, menyinggung tentang anjuran perdamaian yang diinterpretasikan oleh Imam Wahbah sebagai keutamaan perdamaian, seperti yang dilakukan oleh Rasulullah dalam perjanjian Hudaibiyah. QS. An-Nisa’ 4: 1, mengenai keutamaan silaturrahmi, yang dijelaskan oleh Syekh Wahbah sebagai cara untuk mengikat tali persaudaraan. QS. An-Nur 24: 30, menekankan pentingnya menjaga pandangan dan kemaluan, yang relevan dengan bagaimana seseorang menjaga diri dalam bermasyarakat. Hasil penelitian ini diharapkan dapat memberikan wawasan yang lebih mendalam tentang konsep etika sosial dalam Islam menurut pandangan Al-Zuhaili serta berkontribusi pada pemahaman yang lebih baik tentang nilai-nilai moral dan perilaku yang dianjurkan oleh Islam untuk membangun masyarakat yang adil dan sejahtera.</p>
PENGARUH KUALITAS PELAYANAN TERHADAP KEPUASAN NASABAH PADA PT. PEGADAIAN CABANG RAWAMANGUN
Authors: Adrian Christoper , Wahyudi Dedy 
Published: June 2024

Lembaga-lembaga keuangan adalah bagian yang diperlukan dari kegiatan ekonomi setiap negara. Lembaga keuangan mempunyai peran yang penting dalam aktivitas ekonomi sebagai pihak yang yang dapat menghimpun serta menyalurkan dana masyarakat secara efektif demi tercapaiya taraf hidup suatu masyarakat yang kemudian akan disalurkan untuk pendanaan. Lembaga keuangan di Indonesia dibagi menjadi dua jenis yaitu lembaga keuangan bank dan Lembaga keuangan bukan bank, keduanya memiliki peran yang penting terhadap distribusi keuangan di masyarakat. Pegadaian adalah satu jenis lembaga keuangan bukan bank yang banyak digunakan di tengah masyarakat. Seiring dengan kemajuan zaman, banyak pesaing dalam bidang yang sama muncul, sehingga cabang tersebar di berbagai wilayah, seperti di wilayah PT. Pegadaian cabang Rawamangun. Tujuan penelitian ini untuk menganalisis pengaruh kualitas pelayanan terhadap kepuasan nasabah. Jenis penelitian dalam penelitian ini menggunakan analisis deskriptif kuantitatif. Populasi dalam penelitian ini berjumlah 82.384 nasabah, dan sampel 100 orang yang didapat menggunakan teknik purposive sampling. Teknik pengumpulan data menggunakan kuesioner skala likert yang masing-masing telah diuji coba dan memenuhi syarat validitas dan reliabilitas. Penelitian ini menggunakan analisis regresi linear sederhana dengan pengujian yang digunakan yaitu uji t dan uji koefisien determinasi dengan program SPSS 29. Hasil penelitian ini menunjukan bahwa kualitas pelayanan berpengaruh signifikan terhadap kepuasan nasabah dengan kontribusi sebesar 58,5%, sedangkan sisanya sebesar 41,5% dipengaruhi oleh variabel lain yang tidak diteliti dalam penelitian ini seperti promosi, harga, kualitas produk, dan lain-lain.
POTRET KADAR GLUKOSA DAN UREA DARAH SEBAGAI INDIKATOR STATUS KESEHATAN DAN NUTRISI KAMBING PERANAKAN ETAWA DI PUSAT PENGEMBANGAN KAMBING PERANAKAN ETAWA DI KABUPATEN BANYUMAS
Authors: Sembodo Nugroho  , Yusuf Subagyo  , Hermawan Setyo Widodo  , Mas Yedi Sumaryadi  , Efka Aris Rimbawanto  
Published: June 2024

Kambing Peranakan Etawa (PE) merupakan salah satu jenis kambing lokal yang banyak dibudidayakan di Indonesia, karena memiliki keunggulan dibandingkan dengan jenis lainnya pada produksi daging, susu, mudah beradaptasi, tahan penyakit dan penampilan yang khas. Banyumas merupakan salah satu daerah pusat pengembangan kambing PE. Penelitian ini bertujuan untuk mengetahui status kesehatan dan nutrisi Kambing PE di pusat pengembangan kambing PE di Banyumas melalui uji Biokimia darah (glukosa dan Urea Darah). Pemilihan sampel dilakukan secara purposive sampling, dengan menjadikan Kecamatan Gumelar, Kabupaten Banyumas sebagai sentra pengembangan. Sebanyak 40 ekor kambing PE laktasi dari empat kelompok ternak yang berbeda, diambil sampel darah 3 ml kemudian dianalisis secara spektrofotometer. Evaluasi dilakukan melalui uji kadar biokimia darah (kadar glukosa dan urea darah). Kadar glukosa dan urea darah memiliki perbedaan yang signifikan P<(0.05) antar kelompok ternak, dengan kadar glukosa tertinggi 70.56 ± 4.33 mg/dl, terendah 37.89 ± 3.53 mg/dl, sedangkan untuk urea darah tertinggi 60.83 ± 8.93 mg/dl, terendah 50.83 ± 5.64 mg/dl. Hasil kadar biokimia darah masih dalah rentan standar kambing normal.
Kognisi Pelaku Industri Pariwisata Di Yogyakarta Mengenai Makna Kata Profesional (Kajian Semantik Prototype)
Authors: Devita Widyaningtyas Yogyanti  , Annisaa Nurul Atiqah  
Published: June 2024

In the working wold, the word “professional” related with some features of meaning which create the meaning of the word totally. To avoid different cognition among people in seeing the case of “professional”, therefore it is important to make the standard measurement as the guideliness. The different perception about what people said about “professional” can appear as a problem in the working world when there is a dissagreement cognition among the staffs. Therefore this research aimed to find the features of meaning which form the meaning of “professional”, which is the features of meaning that can be the main guideliness for a worker in doing job. The method used are qualitative and quantitative. Quantitative method used for counting and processing the result answer from the participant, who are the staffs of tourism industry, in the form of number. Qualitative method later will be used to elaborate the result in the form of sentences related to the concept of the word “professional”. Based on the analyzed data, it is found that the features which form the meaning of the word “professional” from the point of view of tourism industry workers in Yogyakarta are ability, discipline, and altruism manner. In this case, altruism manner become the most important feature in finding the level of one’s professionalism.
PENDAMPINGAN KELUARGA DENGAN BALITA DALAM PEMANFAATAN TANAMAN LOKAL DAUN KELOR DI RW 09 KELURAHAN KARANNGSARI KECAMATAN NEGLASARI KOTA TANGERANG TAHUN 2023
Authors: Sari Dewi Indah 
Published: June 2024

Kasus stunting di Kota Tangerang menunjukkan bahwa masih diperlukan upaya pencegahan dan penurunan stunting. Pada tahun 2024, target nasional prevalensi stunting adalah sebesar 14%, sehingga masih diperlukan upaya pencegahan dan penanganan stunting untuk dapat mencapai target tersebut. Hasil pengukuran status gizi balita berdasarkan indeks panjang badan/tinggi badan menurut umur di 13 kecamatan Kota Tangerang tahun 2021 kecmatan Neglasari menyumbang 6.47% prevalensi stunting. Solusi yang ditawarkan dalam kegiatan pengabdian masyarakat Program Kemitraan Masyarakat antara lain melakukan edukasi, pelatihan dan pendampingan tentang stunting (penyebab, pencegahan dan terapi), meningkatkan ketahanan masyarakat desa melalui pemberdayaan kelompok masyarakat organisasi sosial, kader-kader kesehatan dengan Pelatihan pembuatan makanan dari tanaman daun kelor bergizi dan memiliki nilai ekonomi serta pemberian dan penanaman pohon kelor di sekitar warga diharapkan masyarakat memiliki bahan baku dalam pembuatan pudding kelor dan program dapat berkelanjutan. Luaran Wajib antara lain adanya video Pelaksanaan pendampingan pembuatan pudding kelor yang bersetifikat Haki, Buku saku tentang pemanfaatan tanaman kelor sebagai tanaman pekarangan pekarangan yang dapat menjadi bahan makanan untuk peningkatan gizi balita untuk pencegahan stunting dan bernilai ekonomi, artikel yang dipublikasi. Target Capaian Pelaksanaan Pengabdian Masyarakat antara lain peningkatan pengetahuan dan keterampilan dengan pendampingan kepada keluarga yang memiiki balita dengan pemanfaatan tanaman kelor yang dapat membantu meningkatkan gizi keluarga serta ekonomi.
Pengenalan Sexs Education Melalui Video Edukasi sebagai cara Pencegahan Kekerasan Seksual pada Anak
Authors: Aisyah Putri Rawe Mahardika  
Published: June 2024

Kasus kekerasan seksual pada anak setiap tahunnya mengalami peningkatan. Pelecehan terhadap anak memiliki dampak yang besar untuk anak dikemudian hari. Dapat terjadi masalah fisik maupun masalah psikologis. Pelaku pelecehan seksual dapat dari orang terdekat anak, seperti dari keluarga, tetangga ataupun lingkungan sekolah. Salah satu cara preventif yang dapat dilakukan ialah seks edukasi. Pendidikan seks pada usia dini juga diharapkan mampu memberikan pengetahuan dasar sesuai dengan norma, pertahanan diri sehingga anak tidak menjadi korban pelecehan. Seks edukasi pada anak dapat berupa pengenalan anggota tubuh dengan menggunakan metode pembelajaran sosialisasi dan video. Sasaran sosialisasi yang dilakukan adalah siswa sekolah dasar kelas empat,lima dan enam. Hasil sosialisasi yang dilakukan anak lebih memahami bagian tubuhnya dan dapat lebih waspada dan dapat menolak saat orang lain mencoba memegang area pribadi anak sehingga dapat menghindarkan anak dari kekerasan seksual.
Rehabilitation Treatment Of Tuberculosis Of The Knee Joint (Gonitis Tuberculosis) After Synovectomy Surgery: A Case Report
Authors: Wahyudi Heru , Rama Susilawati Mami Losa 
Published: June 2024

Introduction: The incidence of extrapulmonary tuberculosis (EPT) cases is increasing globally. with bones and joints being the most common sites, accounting for over 10% of occurrences. Tuberculosis of the knee is rare case, presents challenges in prompt diagnosis, leading to severe progressive pain and functional impairment that significantly impacts the patient's quality of life.
Case Persentation: A 42-year-old male patient experienced chronic pain in the right knee joint, stiffness and limitations when moving the knee. Physical examination showed swelling, warmth and redness. The range of movement of the knee was limited. Histopathological examination showed that the patient was diagnosed with tuberculosis of the knee. Synovectomy was performed after a diagnosis of tuberculosis of the knee and followed by a 9-month anti-tuberculosis drugs regimen. Knee range of motion (ROM) exercise and diathermy therapy showed clinical improvement after prompt management since the initiation of progressive rehabilitation therapy.
Conclusion: Tuberculosis of the knee is a rare complication of tuberculosis which has the potential to cause functional impairment and affect the quality of life. Providing physiotherapy interventions in the form of exercises and diathermy therapy in post-synovectomy cases for one year resulted in significant functional progress.
III. Mustafa’nın Bostancılar Ocağı Kütüphanesi ve Vakfettiği Kitaplar
Authors: Özler Muhammed , Demirel Kadir 
Published: June 2024

III. Mustafa tarafından kurulan Bostancılar Ocağı Kütüphanesi hakkında bazı bilgiler bulunuyorsa da söz konusu kütüphane ile ilgili şimdiye dek müstakil ve kapsamlı bir inceleme yapılmamıştır. Osmanlı kütüphaneciliğinin zirveye çıktığı XVIII. yüzyılda tesis edilmiş olan bu kütüphane hakkındaki bilgilerin sınırlı oluşu ve kitaplarının kataloğunun yayınlanmamış olması da adı geçen kütüphanenin kültürel değerinin anlaşılmasını güçleştirmiştir.
Osmanlı kütüphaneciliğine katkıda bulunmak amacıyla vakfiye ve arşiv kaynakları temel alınarak kaleme alınan bu makale; giriş, iki ana bölüm ve eklerden oluşmaktadır. Giriş kısmında kısaca III. Mustafa’nın hayatından bahsederek onun kitaplara duyduğu ilgiyi açıklayacak ve XVIII. yüzyılın ilk yarısında padişahlar tarafından kurulan kütüphanelere ait örnekleri sunacağız. Birinci bölümde Bostancılar Ocağı Kütüphanesi’nin kuruluşu, işleyişi, personelleri, personel ücretleri, fizikî yapısı ve kütüphanedeki kitapların Lâleli Kütüphanesi’ne aktarılma sürecini değerlendireceğiz. İkinci bölümde ise kütüphanenin kataloğunu tanıttıktan sonra kitaplarla ilgili istatistiksel bilgiler verecek, vakfedilen kitapların hangi konulara ait olduğunu belirtecek ve ana hatlarıyla kitapların özelliklerine değineceğiz. Ekler bölümünde de kütüphanede bulunan kitapların tam listesini, kütüphaneye ait muhasebe kayıtları ile kütüphane kitaplarının Lâleli Kütüphanesi’ne taşınması sürecine dair belgeleri neşredeceğiz.