bluuebunny/crossref_metadata_2025_split huggingface dataset:
‘Make Me Believe!’: Ghost-hunting technology and the postmodern fantastic
Authors: Lauro Sarah Juliet , Paul Catherine 
Published: September 2013

Abstract
Contemporary representations of the paranormal are framed both as fiction and reality. Many primetime programmes showcase paranormal phenomena while positing themselves as documentary television. This article looks at one subgenre of paranormal reality shows, ghost hunting, and specifically at its uses of technology as a way of positioning the art of ghost hunting as a scientific endeavour. At the same time, we consider the rhetorical technologies that are put into place, not only in such ghost-hunting programmes, but also in the ghost tourism industry, in order to, as one of the brothers on the show Ghost Lab said defiantly to the invisible specters with whom he was trying to communicate: ‘Make me believe!’ Putting paranormal reality television in dialogue with historical records of the spiritualist movement of the nineteenth and early twentieth centuries, we explore the differences between the Gothic, Victorian, Modern and (what we might call) Postmodern Fantastic: contemporary paranormal narratives that offer its viewers the ability to sustain the sense of ambivalence produced in the Fantastic indefinitely, by allowing them to believe without being believers.
On a congruence prime criterion for cusp forms on GL2 over number fields
Authors: Namikawa Kenichi 
Published: September 2013

Abstract

Let f be a normalized Hecke eigenform on GL2 over a number field F and let 𝔓 be a prime ideal of a number field which contains the Galois closure of the number field which is generated by all Fourier coefficients of f over F. In this paper, we give a sufficient condition for 𝔓 to be a congruence prime for f.
This criterion is a generalization of congruence prime criteria which were known for the case of elliptic cusp forms by Hida,
for the case where F is an imaginary quadratic field by Urban
and for the case of Hilbert cusp forms by Ghate and Dimitrov to arbitrary number fields.
Stressed to death – mechanisms of ER stress-induced cell death
Authors: Sovolyova Natalia , Healy Sandra , Samali Afshin , Logue Susan E. 
Published: September 2013

Abstract
The endoplasmic reticulum (ER) is a highly dynamic organelle of fundamental importance present in all eukaryotic cells. The majority of synthesized structural and secreted proteins undergo post-translational modification, folding and oligomerization in the ER lumen, enabling proteins to carry out their physiological functions. Therefore, maintenance of ER homeostasis and function is imperative for proper cellular function. Physiological and pathological conditions can disturb ER homeostasis and thus negatively impact upon protein folding, resulting in an accumulation of unfolded proteins. Examples include hypoxia, hypo- and hyperglycemia, acidosis, and fluxes in calcium levels. Increased levels of unfolded/misfolded proteins within the ER lumen triggers a condition commonly referred to as ‘ER stress’. To combat ER stress, cells have evolved a highly conserved adaptive stress response referred to as the unfolded protein response (UPR). UPR signaling affords the cell a ‘window of opportunity’ for stress resolution however, if prolonged or excessive the UPR is insufficient and ER stress-induced cell death ensues. This review discusses the role of ER stress sensors IRE1, PERK and ATF6, describing their role in ER stress-induced death signaling with specific emphasis placed upon the importance of the intrinsic cell death pathway and Bcl-2 family regulation.
The role of GRASPs in morphological alterations of Golgi apparatus: mechanisms and effects
Authors: Ji Guang , Ji Hui , Mo Xiaoye , Li Ting , Yu Yaduo , Hu Zhiping 
Published: September 2013

Abstract
The Golgi apparatus (GA) is a pivotal organelle in cell metabolism, functioning not only in the processing and transportation of cargoes but also in ion homeostasis, cell apoptosis, and stress sensing. We are interested in the intricate role of GA and the recently present novel concept of ‘GA stress’. GA shows various morphological alterations in many neurodegenerative diseases and cell apoptosis induced by biochemical reagents, mechanisms in which oxidative stress is strongly involved. In turn, the structural changes and morphological alterations of the GA could also transduce stress signals. Therefore, besides the biochemical changes, more attention should be paid to the morphological alterations of the GA itself during pathological processes and diseases. The Golgi reassembly and stacking proteins (GRASPs) have been identified as important components acting in the transformation of Golgi structure, and they may thus affect the Golgi functions and cell behavior. In this review, we will discuss the intricate role of the GRASPs in remodeling the GA morphology and focus on their mechanisms and effects in the processes of Golgi stacking, mitosis, cell apoptosis, and cargo secretion. We would also like to provide a further prospective of their potential biological values in neurodegenerative diseases.
Testosterone deficiency is associated with increased risk of mortality and testosterone replacement improves survival in men with type 2 diabetes
Authors: Muraleedharan Vakkat , Marsh Hazel , Kapoor Dheeraj , Channer Kevin S , Jones T Hugh 
Published: September 2013

ObjectiveMen with type 2 diabetes are known to have a high prevalence of testosterone deficiency. No long-term data are available regarding testosterone and mortality in men with type 2 diabetes or any effect of testosterone replacement therapy (TRT). We report a 6-year follow-up study to examine the effect of baseline testosterone and TRT on all-cause mortality in men with type 2 diabetes and low testosterone.Research design and methodsA total of 581 men with type 2 diabetes who had testosterone levels performed between 2002 and 2005 were followed up for a mean period of 5.8±1.3 s.d. years. Mortality rates were compared between total testosterone >10.4 nmol/l (300 ng/dl; n=343) and testosterone ≤10.4 nmol/l (n=238). The effect of TRT (as per normal clinical practise: 85.9% testosterone gel and 14.1% intramuscular testosterone undecanoate) was assessed retrospectively within the low testosterone group.ResultsMortality was increased in the low testosterone group (17.2%) compared with the normal testosterone group (9%; P=0.003) when controlled for covariates. In the Cox regression model, multivariate-adjusted hazard ratio (HR) for decreased survival was 2.02 (P=0.009, 95% CI 1.2–3.4). TRT (mean duration 41.6±20.7 months; n=64) was associated with a reduced mortality of 8.4% compared with 19.2% (P=0.002) in the untreated group (n=174). The multivariate-adjusted HR for decreased survival in the untreated group was 2.3 (95% CI 1.3–3.9, P=0.004).ConclusionsLow testosterone levels predict an increase in all-cause mortality during long-term follow-up. Testosterone replacement may improve survival in hypogonadal men with type 2 diabetes.
Medication Adherence and Health Care Utilization in Pediatric Chronic Illness: A Systematic Review
Authors: McGrady Meghan E. , Hommel Kevin A. 
Published: September 2013

BACKGROUND AND OBJECTIVE:
Advanced understanding of modifiable predictors of health care use in pediatric chronic illness is critical to reducing health care costs. We examined the relationship between medication non-adherence and health care use in children and adolescents who have a chronic medical condition.

METHODS:
A systematic review of articles by using PubMed, PsycINFO, and CINAHL was conducted. Additional studies were identified by searching reference sections of relevant manuscripts. Studies that tested the relationship between medication non-adherence and health care use (ie, hospitalizations, emergency department visits, outpatient visits) or cost in children and adolescents (mean age ≤18 years) who have a chronic medical condition were included. Extraction of articles was completed by using predefined data fields.

RESULTS:
Ten studies met our inclusion criteria. Nine of the 10 studies reviewed (90%) demonstrated a relationship between medication non-adherence and increased health care use. The directionality of this relationship varied depending on the outcome variable of interest.

CONCLUSIONS:
Medication non-adherence is related to increased health care use in children and adolescents who have a chronic medical condition and should be addressed in clinical care. Future studies should include randomized controlled trials examining the impact of adherence promotion efforts on health care use and costs.
Comparison of the Proportion of Non‐Classic (CD14+CD16+) Monocytes/Macrophages in Peripheral Blood and Gingiva of Healthy Individuals and Patients With Chronic Periodontitis
Authors: Jagannathan Raghunathan , Lavu Vamsi , Rao Suresh Ranga 
Published: September 2013

Background: Monocyte subsets with low CD14 expression that coexpress CD16 (CD14+CD16+) are called non‐classic or hyperinflammatory monocytes. Previous studies have reported an increase in the percentage of CD14+CD16+ monocytes in the peripheral blood of patients with chronic periodontitis (CP). To our knowledge, there are no reports demonstrating the presence of CD14+CD16+ monocyte–derived macrophages (MDMs) in the gingival tissue. The objective of this study is to identify the proportion of non‐classic (CD14+CD16+) monocytes/macrophages in peripheral blood and gingiva of healthy individuals and patients with CP.Methods: A total of 60 individuals (n = 30 per group) were recruited for the study. Group 1 included 30 individuals with healthy gingiva, and group 2 included 30 patients with CP. Direct immunofluorescent staining was done in 200 μL whole‐blood and single‐cell suspensions obtained from gingival tissue, with fluorochrome‐conjugated monoclonal antibodies against CD14, CD16, and human leukocyte antigen‐DR (HLA‐DR), and subjected to flow cytometric analysis.Results: The mean percentage of CD14+CD16+ monocytes in the peripheral blood of healthy individuals was 9.10% ± 1.39%, and for patients with CP it was 14.18% ± 2.69% (P <0.05). The mean percentage of CD14+CD16+ MDMs in the gingival tissue of healthy individuals was found to be 0.93% ± 0.33%, whereas in patients with CP, it was 1.92% ± 0.78% (P <0.01). Non‐classic monocytes/macrophages showed a high median fluorescent intensity for HLA‐DR (DR++).Conclusion: This study demonstrates an increased proportion of CD14+CD16+HLA‐DR++ monocytes/macrophages in the peripheral blood and gingiva of patients with CP.
Population‐Based 5‐Year Follow‐Up Study in Taiwan of Osteoporosis and Risk of Periodontitis
Authors: Chang Wei‐Pin , Chang Wei‐Chiao , Wu Mei‐Shin , Pai Jei‐Tsung , Guo Yuh‐Cherng , Chen Ku‐Chung , Liu Mu‐En , Chiu Wen‐Ta , Hung Kuo‐Sheng 
Published: September 2013

Background: Osteoporosis and periodontitis are both considered global health issues that threaten postmenopausal women and the older population. However, the correlation between osteoporosis and periodontitis is still unclear.Methods: Using a nationwide Taiwanese population‐based database, data from patients with osteoporosis (2003 to 2005; n = 2,527) and 7,575 individuals who were matched to each patient by age and sex were analyzed. All participants were tracked for 5 years from the date of enrollment to observe the percentage of patients who developed periodontitis. Cox proportional hazard regressions were performed to evaluate 5‐year periodontitis‐free survival rates.Results: Among the total sample, 3,060 individuals were diagnosed with periodontitis during the 5‐year follow‐up period: 792 in the study cohort and 2,268 in the comparison cohort. The adjusted hazard ratio for periodontitis in patients with osteoporosis compared with individuals without osteoporosis during the 5‐year follow‐up was 1.14 (95% confidence interval = 1.05 to 1.24, P <0.01).Conclusion: This population‐based study indicated that patients with osteoporosis may have an increased risk of periodontitis.
Platelet‐Rich Plasma, Low‐Level Laser Therapy, or Their Combination Promotes Periodontal Regeneration in Fenestration Defects: A Preliminary In Vivo Study
Authors: Nagata Maria J.H. , de Campos Natália , Messora Michel R. , Pola Natália M. , Santinoni Carolina S. , Bomfim Suely R.M. , Fucini Stephen E. , Ervolino Edilson , de Almeida Juliano M. , Theodoro Letícia H. , Garcia Valdir G. 
Published: September 2013

Background: This study histomorphometrically analyzes the influence of platelet‐rich plasma (PRP), low‐level laser therapy (LLLT), or their combination on the healing of periodontal fenestration defects (PFDs) in rats.Methods: PFDs were surgically created in the mandibles of 80 rats. The animals were randomly divided into four groups: 1) C (control) and 2) PRP, defects were filled with blood clot or PRP, respectively; 3) LLLT and 4) PRP/LLLT, defects received laser irradiation, were filled with blood clot or PRP, respectively, and then irradiated again. Animals were euthanized at either 10 or 30 days post‐surgery. Percentage of new bone (NB), density of newly formed bone (DNB), new cementum (NC), and extension of remaining defect (ERD) were histomorphometrically evaluated. Data were statistically analyzed (analysis of variance; Tukey test, P <0.05).Results: At 10 days, group PRP presented ERD significantly lower than group C. At 30 days, group PRP presented NB and DNB significantly greater than group C. Groups LLLT, PRP, and PRP/LLLT showed significant NC formation at 30 days, with collagen fibers inserted obliquely or perpendicularly to the root surface. NC formation was not observed in any group C specimen.Conclusions: LLLT, PRP, or their combination all promoted NC formation with a functional periodontal ligament. The combination PRP/LLLT did not show additional positive effects compared to the use of either therapy alone.
Case History: Clay Free Invert Fluid in Norwegian High-Temperature Well Provides Consistent Low ECD Profile
Authors: Rødsjø Mads , Akutsu Erik , Morris Steven , Mikalsen Renate 
Published: September 2013

Abstract
Historically, invert emulsion drilling fluids (IEFs) require organophilic clays to provide viscosity and suspension characteristics. Whilst effective, these chemicals are prone to stratification in certain conditions, slow chemical reaction times, high pressure spikes, and high equivalent circulating densities (ECDs) attributed to the solids contribution and inherent chemistry of the fluid.
To help reduce such adverse effects, clay based chemicals used in IEFs can be replaced with highly sophisticated polymer viscosifiers, filtration agents, and emulsifiers, which provide a strong, stable emulsion, even with low-oil/water ratio (OWR) IEFs.
Legislation governing the energy industry’s use of chemicals in Norway prohibits use of certain products that are otherwise globally used in drilling fluids. To address such restrictions, extensive research and development has resulted in availability of environmentally acceptable chemicals that produce the unique rheological and suspension characteristics inherent to clay-free IEF systems.
This paper describes the first application of clay-free IEFs in the Norwegian continental shelf (NCS) with an emphasis on an impressively low ECD contribution far more consistent than previously recorded in comparable wells. Further, a treatment was developed to allow the IEFs to be used to drill into a section exhibiting temperatures greater than 160°C. Chemical consumption was substantially lower compared to previous wells using traditional IEF systems, thus reducing shipping requirements.
Before planning the subject well, the environmentally acceptable chemicals intended for use were approved by governing bodies. Consequently, a vertical exploration prospect was selected as the initial well to be drilled using a clay-free IEF. This well was comparable to a previously drilled high pressure/high-temperature HP/HT well, allowing direct comparison of several of the metrics.
The Use of Multi Rotor Remotely Opearated Aerial Vehicles (Roavs) as a Method of Close Visual Inspection (CVI) of Live and Difficult to Access Assets on Offshore Platforms
Authors: Buchan Philip , Connolly Malcolm 
Published: September 2013

Abstract
There is a continual requirement to carry out close visual inspections of plant and equipment on offshore installations for ongoing maintenance. Accessing structures at height or live systems on a process plant poses a number of challenges. ‘Traditional’ methods-of-access to carry out inspection of high or difficult to reach parts of an installation involve using rope access techniques, scaffolding or even full-size helicopters. Rope access inspection can be time-consuming and although it has an excellent safety record it is still potentially dangerous as it involves personnel working at height which is statistically the single biggest cause of workplace fatalities accounting for 25% (5). Scaffolding as an access method for inspection can be expensive, time-consuming and also involves a significant amount of working at height or manual handling operations. While full-size helicopter inspection can mean that many parts of a rig are simply uninspectable, for example the underdeck of a platform. These inspections can also put offshore platforms at a huge commercial disadvantage as assets such as flares need to be shutoff or drilling derricks require drilling activities to stop before the inspection can be completed.
A new method of inspecting live and difficult to access assets has now been developed that allows certain inspection tasks to be performed quicker, safer and more cost effectively than traditional methods. Similar to underwater Remote Operated Vehicles (ROVs), it involves allying engineering expertise to the use of Remotely Operated Aerial Vehicles (ROAVs) for topside and above the waterline inspection. These miniature flying vehicles use HD video, HD still and thermal cameras to provide detailed images for inspection purposes. ROAVs are operated by highly trained pilots in combination with qualified engineers and plant inspectors to create authoritative technical reports and analysis. Offshore operators now have another method available to them to gather information and understand the condition of their assets without shutting down operations allowing informed decision making.
The use of ROAVs for the visual and thermal inspection of onshore structures in refineries and chemical plants has become an established technique over the last 4 years. This technique is starting to become adopted as best practice by some operators for visual inspection of certain assets such as flare stacks. The potential of the technique of using ROAV for certain inspection tasks is now being recognised in an offshore context with the first use of this technology in the North Sea in January 2012.
This paper provides an introduction to the concept of inspection using ROAVs, overview of the technology, benefits of the technique, limitations of its application, safety considerations, case studies and a look to the future for the industry.
Offshore Horizontal Well Fracturing: Operational Optimisation in the Southern North Sea
Authors: Langford Marc , Holland Brian , Green Christopher A. , Bocaneala Bogdan , Norris Mark 
Published: September 2013

Abstract
Recently, there has been an increased interest in optimising horizontal multifrac completion technologies used to complete unconventional US onshore wells. The developing technologies and techniques are increasingly being used for offshore applications and have found widespread use in horizontal wells in areas such as the southern North Sea. This case history describes the application of two complementary technologies which have enabled the placement of 1.4 million pounds of proppant in four treatments within 4 consecutive days. Prior to this similar offshore completion operations have typically taken 12 to 25 days.
Historically, cemented liners and "plug-and-perf" completions have been used for horizontal fracturing in the southern North Sea. Such operations often involve extensive coiled tubing interventions between fracturing stages. This introduces unnecessary technical and associated operational risks due to the extended, long horizontal well architectures that are often used. An openhole, ball-activated multi-stage system, recently introduced into the North Sea, was applied in tandem with the application of a new environmentally-compliant seawater fracturing fluid. The use of the seawater-based system allowed sufficient fluid volume to be loaded and pumped for the placement of four hydraulic fracturing treatments on consecutive days, without the need for the vessel to disconnect and sail back to port to reload fresh water.
As a result of this dual development and correct application of the completion technologies, the requirement for coiled-tubing interventions between stages was eliminated, saving both vessel and rig time. Ultimately, such savings result in faster turnaround times for wells to be placed on production, thereby improving overall well economics. Following the success of the application of this technology the operator is actively pursuing similar new complimentary technologies. Such operational improvements will not only enhance well economics, but possibly define future North Sea fracturing operations.
Minimising Underwater Noise Impact from Offshore Activities
Authors: Fulton Natalia , Kuo Chengi 
Published: September 2013

Abstract
This paper is concerned with human activities relating to offshore exploration and exploitation that have adverse effects on marine animals. It addresses noise pollution caused by tasks such as piling, drilling, exploration etc. Loud noise produced during offshore operations can seriously affect one of the main senses – hearing. The paper examines sources of noise and methods of mitigating it to tolerable levels. Research is focused on the use of bubble curtains for noise reduction. The main conclusion is that the bubble curtain is a recognised noise reduction/shielding method and its effectiveness is dependent on bubble size and water depth in addition to water temperature, density and salinity.
Low Cycle Fatigue Analysis of Threaded Connectors for Subsea Drilling and Production
Authors: Zhu B. , Steen T. L. , Patterson W. R. , Thomas M. , Balaji Durai , G. Rajesh Kumar 
Published: September 2013

Abstract
Threaded connectors are utilized in a wide range of subsea oil & gas applications, from large diameter conductor casings to smaller diameter risers. As oil & gas drilling and production continues to progress into deeper waters the demand for reliable, cost effective, and high performance connectors will continue to grow. During the development phase of new threaded connectors Finite Element Analysis (FEA) is utilized to evaluate the structural capacity and performance of the connector under a wide range of load scenarios. When tension or bending loads are applied to a threaded connector, the start and end of the thread take significantly more load than the center of the thread. The stress in the thread resulting from this load distribution takes the form of a bathtub and is referred to as a "bathtub curve". Under high cyclic bending and/or tension loading, the start and end of the thread can yield, resulting in a more even load sharing between the entire thread. The magnitude of this re-distribution of load has been analyzed to illustrate its impact on the fatigue performance of threaded connectors.