bluuebunny/crossref_metadata_2025_split huggingface dataset:
The agency of a marmalade machine: Gender, class and mechanical gadgets in the British Kitchen, c.1870–1938
Authors: Carpenter Katie 
Published: August 2024

AbstractThis article explores the marmalade machine, a mechanical device designed to slice orange peel. These niche objects were manufactured between roughly 1870 and 1938 in Britain. As a so‐called ‘labour‐saving’ gadget, the marmalade machine sliced orange peel quickly and effectively, removing the tedious process of slicing orange peel by hand. However, like many labour‐saving technologies, it also required an extended skillset from the housewife, by necessitating a mechanical and intellectual engagement from the user. Drawing on an eclectic range of source material, including physical examination of the machines, this article argues that the marmalade machine possessed agency through its affordances.
Clustering and unconstrained ordination with Dirichlet process mixture models
Authors: Stratton Christian , Hoegh Andrew , Rodhouse Thomas J. , Green Jennifer L. , Banner Katharine M. , Irvine Kathryn M. 
Published: August 2024

Abstract

Assessment of similarity in species composition or abundance across sampled locations is a common goal in multi‐species monitoring programs. Existing ordination techniques provide a framework for clustering sample locations based on species composition by projecting high‐dimensional community data into a low‐dimensional, latent ecological gradient representing species composition. However, these techniques require specification of the number of distinct ecological communities present in the latent space, which can be difficult to determine in advance.

We develop an ordination model capable of simultaneous clustering and ordination that allows for estimation of the number of clusters present in the latent ecological gradient. This model draws latent coordinates for each sample location from a Dirichlet process mixture model, affording researchers with probabilistic statements about the number of clusters present in the latent ecological gradient.

The model is compared to existing methods for simultaneous clustering and ordination via simulation and applied to two empirical datasets; JAGS code to fit the proposed model is provided in an appendix. The first dataset concerns presence‐absence records of fish in the Doubs river in eastern France and the second dataset describes presence‐absence records of plant species in Craters of the Moon National Monument and Preserve (CRMO) in Idaho, USA. Results from both analyses align with existing ecological gradients at each location.

Development of the Dirichlet process ordination model provides wildlife managers with data‐driven inferences about the number of distinct communities present across monitored locations, allowing for more cost‐effective monitoring and reliable decision‐making for conservation management.
Proton pump inhibitor effect on esophageal protein signature of eosinophilic esophagitis, prediction, and evaluation of treatment response
Authors: Molina‐Jiménez Francisca , Ugalde‐Triviño Lola , Arias‐González Laura , Armenteros Elisa , Relaño‐Rupérez Carlos , Casabona Sergio , Moreno‐Monteagudo José Andrés , Pérez‐Fernández María Teresa , Martín‐Domínguez Verónica , Fernández‐Pacheco Jennifer , Laserna‐Mendieta Emilio José , Muñoz‐Hernández Patricia , García‐Martínez Jorge , Muñoz Javier , Lucendo Alfredo J. , Santander Cecilio , Majano Pedro 
Published: August 2024

AbstractBackgroundRecently, we have identified a dysregulated protein signature in the esophageal epithelium of eosinophilic esophagitis (EoE) patients including proteins associated with inflammation and epithelial barrier function; however, the effect of proton pump inhibitor (PPI) treatment on this signature is unknown. Herein, we used a proteomic approach to investigate: (1) whether PPI treatment alters the esophageal epithelium protein profile observed in EoE patients and (2) whether the protein signature at baseline predicts PPI response.MethodsWe evaluated the protein signature of esophageal biopsies using a cohort of adult EoE (n = 25) patients and healthy controls (C) (n = 10). In EoE patients, esophageal biopsies were taken before (pre) and after (post) an 8‐week PPI treatment, determining the histologic response. Eosinophil count PostPPI was used to classify the patients: ≥15 eosinophils/hpf as non‐responders (non‐responder) and < 15 eosinophils/hpf as responders (R). Protein signature was determined and differentially accumulated proteins were characterized to identify altered biological processes and signaling pathways.ResultsComparative analysis of differentially accumulated proteins between groups revealed common signatures between three groups of patients with inflammation (responder‐PrePPI, non‐responder‐PrePPI, and non‐responder‐PostPPI) and without inflammation (controls and responder‐PostPPI). PPI therapy almost reversed the EoE specific esophageal protein signature, which is enriched in pathways associated with inflammation and epithelial barrier function, in responder‐PostPPI. Furthermore, we identified a set of candidate proteins to differentiate responder‐PrePPI and non‐responder‐PrePPI EoE patients before treatment.ConclusionThese findings provide evidence that PPI therapy reverses the alterations in esophageal inflammatory and epithelial proteins characterizing EoE, thereby providing new insights into the mechanism of PPI clinical response. Interestingly, our results also suggest that PPI response could be predicted at baseline in EoE.
Characteristics of oncology patients with fever and invasive bacterial infections diagnosed
Authors: Gomez Borja , Almarza Fernando , López‐Almaraz Ricardo , Quintana Oriol , Mintegi Santiago 
Published: August 2024

AbstractAimTo describe the characteristics of febrile oncology patients seen in the Paediatric Emergency Department and microbiological characteristics of the invasive bacterial infections (IBIs) diagnosed.MethodsWe conducted a prospective observational study of febrile oncology patients seen between 2016 and 2022. We divided haematologic cancers by the aggressiveness of the chemotherapy received at the time.ResultsWe included 418 episodes (272 haematologic cancers, 146 solid tumours). The median duration of fever was 2 h (interquartile range: 1–3) and 97.6% of patients were well‐appearing on arrival. We diagnosed 61 IBIs (14.6%), including six episodes of bacterial sepsis. One other episode was coded as sepsis without microbiological confirmation, yielding seven episodes overall (1.7%). Rates of IBI and sepsis were higher among patients with high‐risk haematologic cancers than those with low‐risk haematologic cancers or solid tumours (22.9%, 5.4% and 10.3%, p < 0.01; 3.4%, 0% and 0.7%, p = 0.06, respectively). Leading causes were S. epidermidis (42.6%) and E. coli (14.7%). Gram‐positive bacteria caused 67.2% of non‐septic IBIs and 50% of septic episodes.ConclusionMost febrile oncology patients are well‐appearing and present with a very short history of fever. Prevalence of IBI and sepsis and the main disease‐causing bacteria differ by cancer type and the presence of sepsis.
Why do perfectionists procrastinate (or not)? Exploring the interaction between perfectionism dimensions through self‐determination theory
Authors: Wang Xiao , Howard Joshua L. , Zhong Lifeng 
Published: August 2024

AbstractResearch on perfectionism and workplace procrastination has typically examined perfectionism through two dimensions: perfectionist strivings (PS) and perfectionist concerns (PC), which are inversely associated with procrastination. Recognizing that these two dimensions often coexist in varying degrees within individuals, our study conducted an interaction analysis to elucidate the associations between individual dimensions and their combined presence across four distinct perfectionism profiles. Based on self‐determination theory, we examined the interaction between the two dimensions on procrastination through three psychological mediators: autonomous motivation, controlled motivation, and psychological distress. In a three‐wave study involving 376 employees, we observed that the associations between PS and mediators vary with the level of PC, thus responding to the contentious debate of whether PS are beneficial. Additionally, we employed a three‐way interaction analysis to explore how different profiles of perfectionism react under external performance pressure, particularly in relation to their levels of procrastination. As ambitious perfectionists (high PS, low PC) emerged as the optimal profile under stressors, our study further identified the particularly beneficial role of PS, especially in the presence of stressors. Our analyses shed new light on the relationships between trait perfectionism and workplace procrastination behavior. We discussed theoretical and practical implications.
Long‐term efficacy and safety of dose‐dense and dose‐intense ABVD without consolidation radiotherapy in patients with advanced Hodgkin lymphoma: A 15‐year follow‐up of the ABVDDD‐DI phase II study
Authors: Corazzelli Gaetano , Cuccaro Annarosa , Morelli Emanuela , Arcamone Manuela , De Chiara Annarosaria , Paccone Andrea , Petrillo Antonella , Ibello Francesco , Aversa Corrado , Esposito Maria , Volzone Francesco , Saggese Mariangela , Capobianco Gaetana , Sarno Sabrina , Sirica Letizia , Crisci Stefania , De Filippi Rosaria , Pinto Antonio 
Published: August 2024

SummaryWe demonstrated that dose‐densified and dose‐intensified ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine; ABVDDD‐DI) was safe and effective. Here, we present a post hoc long‐term analysis of the 82 patients enrolled in the original study. The median observation time was 175 months (IQR 159–197). At 15 years, progression‐free and overall survival rates were 81.2% (95% CI, 69.9%–88.7%) and 92.7% (95% CI, 82.6%–97.0%), respectively. Four patients with multiple cardiovascular risk factors experienced delayed G3 cardiac events. The cumulative incidence of second malignancies at 20 years was 6.1%. Fertility and childbearing potential were unaffected. Data support an ongoing benefit for ABVDDD‐DI without uneven late toxicities.
Hybridization in the Anthropocene – how pollution and climate change disrupt mate selection in freshwater fish
Authors: Ramirez‐Duarte Wilson F. , Moran Benjamin M. , Powell Daniel L. , Bank Claudia , Sousa Vitor C. , Rosenthal Gil G. , Schumer Molly , Rochman Chelsea M. 
Published: August 2024

ABSTRACTChemical pollutants and/or climate change have the potential to break down reproductive barriers between species and facilitate hybridization. Hybrid zones may arise in response to environmental gradients and secondary contact between formerly allopatric populations, or due to the introduction of non‐native species. In freshwater ecosystems, field observations indicate that changes in water quality and chemistry, due to pollution and climate change, are correlated with an increased frequency of hybridization. Physical and chemical disturbances of water quality can alter the sensory environment, thereby affecting chemical and visual communication among fish. Moreover, multiple chemical compounds (e.g. pharmaceuticals, metals, pesticides, and industrial contaminants) may impair fish physiology, potentially affecting phenotypic traits relevant for mate selection (e.g. pheromone production, courtship, and coloration). Although warming waters have led to documented range shifts, and chemical pollution is ubiquitous in freshwater ecosystems, few studies have tested hypotheses about how these stressors may facilitate hybridization and what this means for biodiversity and species conservation. Through a systematic literature review across disciplines (i.e. ecotoxicology and evolutionary biology), we evaluate the biological interactions, toxic mechanisms, and roles of physical and chemical environmental stressors (i.e. chemical pollution and climate change) in disrupting mate preferences and inducing interspecific hybridization in freshwater fish. Our study indicates that climate change‐driven changes in water quality and chemical pollution may impact visual and chemical communication crucial for mate choice and thus could facilitate hybridization among fishes in freshwater ecosystems. To inform future studies and conservation management, we emphasize the importance of further research to identify the chemical and physical stressors affecting mate choice, understand the mechanisms behind these interactions, determine the concentrations at which they occur, and assess their impact on individuals, populations, species, and biological diversity in the Anthropocene.
Assessment of prognostic factors in patients with primary ocular adnexal lymphoma when considering competing risk elements
Authors: Zeng Jing , Cao Xian‐Fen , Chen Jian , Liu Zhi‐ping , Lyu Jun , Zhou Qing 
Published: August 2024

AbstractBackgroundAccurate prognostic factors for primary ocular adnexal lymphoma (POAL) are scarce. Survival models and prognostic factors derived without considering competing risk factors suffer from major statistical errors. This study aimed to accurately assess prognostic factors in POAL patients using competing risk models, and compare this to the traditional COX proportional hazards model.MethodsThis retrospective study utilised data from the Surveillance, Epidemiology, and End Results (SEER) program 2010–2015 and included patients with B‐cell POAL. The cumulative incidence function and Gray's test for cause‐specific survival were calculated as univariate analysis. The competing risk models were a Fine‐Gray subdistribution hazard model and a cause‐specific model, and a traditional COX model was employed as a multivariate analysis.ResultsThis study enrolled 846 eligible patients with POAL: 60 patients (7.09%) died from POAL and 123 patients (14.54%) died from other causes. Multivariate competing risk models indicated that age, laterality, histology subtype, the 7th edition of American Joint Committee on Cancer stage T, and radiotherapy were independent predictors for cause‐specific survival of patients with POAL. There was high consistency between the two competing risk models. The COX model made several misestimations on the statistical significance and hazard ratios of prognostic factors.ConclusionsThis study established competing risk models as a method to assess POAL prognostic factors, which was more accurate than traditional methods that do not consider competing risk elements.
A survey exploring ophthalmologists' attitudes and beliefs in performing immediate sequential bilateral cataract surgery in Singapore
Authors: Ng Wen Wei Victoria , Thiyagarajan Shwetha , Tan Clement , Chen David Ziyou 
Published: August 2024

AbstractBackgroundTo evaluate current practice patterns of Immediate Sequential Bilateral Cataract Surgery (ISBCS) by ophthalmologists in Singapore and assess their attitudes towards performing ISBCS in future cataract care.MethodsAn anonymised electronic survey, modified to local context from a similar study conducted in the United Kingdom, was distributed to members of the College of Ophthalmologists, Academy of Medicine, Singapore, from 20 June to 1 September 2023. An initial screening question on prior experience with ISBCS directed the rest of the survey. Questions explored ophthalmologists' current ISBCS practice patterns and the importance of factors affecting their willingness to perform ISBCS. Results were descriptively analysed.ResultsResults collated 2 months upon survey dissemination saw a total of 58 respondents from 235 eligible members (24.7% response rate). Of these, 16 (27.6%) were currently performing ISBCS, 37 (63.8%) had never performed, and 5 (8.6%) had stopped performing. In considering ISBCS, patient convenience (n = 11, 68.8%) and reduced hospital visits (n = 8, 50.0%) were the most important factors nominated. The most important barriers to performing ISBCS were medico‐legal issues (n = 31, 83.8%) and risk of endophthalmitis (n = 27, 73.0%), followed by perceived lack of evidence for its effectiveness (n = 19, 51.4%).ConclusionThis is one of the first studies evaluating ophthalmologists' sentiments towards performing ISBCS in an Asian country. It highlights some of the most pertinent barriers and concerns that ophthalmologists face in performing and offering ISBCS. This study provides a better understanding of the potential role and prospects of ISBCS in future cataract care in Singapore.
Application of the international system for reporting serous fluid cytopathology on pleural effusion cytology with paired pleural biopsy: A new insight and novel approach on risk of malignancy
Authors: Maleki Zahra , Graham Ashleigh J. , Jones Robert , Pastorello Ricardo , Morris Paul , Schmitt Alessandra C. , Rodriguez Erika F. 
Published: August 2024

AbstractIntroductionThe risk of malignancy (ROM) remains an area of interest for further evaluation in reporting systems including in International System for reporting serous fluid cytopathology (TIS), which is a standardized system for reporting effusion cytology. Herein, we report our findings in further investigation of ROM in TIS by studying on paired pleural effusion specimens and corresponding pleural biopsies with emphasis on negative for malignancy, and atypia of undetermined significance categories.Materials and MethodsThe Johns Hopkins Hospital pathology database was retrospectively searched for patients with a pleural biopsy (PBX) and a paired pleural effusion (PF) cytology specimens over a 4‐year period. We employed the TIS categories. The following statistical parameters were evaluated: sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and ROM.ResultsA total of 223 patient cases were included. Effusions TIS reclassification and ROM were as follows: 1.8% non‐diagnostic (ROM 75%), 75.8% negative for malignancy (ROM 23%), 4.9% atypical cells of undetermined significance (ROM 45%), 2.2% suspicious for malignancy (ROM 80%), and 15.2% malignant (ROM 100%). Overall accuracy, sensitivity, specificity, PPV and NPV were calculated and were 79.4%, 45%, 97.7%, 91.2% and 77%, respectively. Among, discordant cases diagnosed negative for malignancy on PF and positive for malignancy on PBX, there were significant number of lymphomas, mesotheliomas, and sarcomas. Lung cancer was the most common carcinoma; however, rare types of carcinomas were noted. Cells blocks and immunohistochemistry (IHC) studies were utilized to confirm either malignant conditions or rule out malignancy in both cell blocks and histology biopsies.ConclusionThis study demonstrates the high specificity and ROM for ‘malignant’ and ‘suspicious for malignancy’ categories in the TIS reporting system and highlights the modest negative predictive value for the ‘negative for malignancy’ category. Although Tissue biopsies are usually considered as ‘gold standard’, any definitive diagnosis of malignancy of body fluid should be considered positive for malignancy in further clinical decision‐making.
The impact of a preopening session on subsequent trading: An experimental analysis
Authors: Caferra Rocco , Morone Andrea , Nuzzo Simone 
Published: August 2024

AbstractIn this study, we examine the influence of a preopening call market (CM) session on the subsequent continuous double auction (CDA) trading phase within a combined market structure (CMDA). We propose that the introduction of a CM phase before the CDA could potentially mitigate price volatility during the CDA by facilitating the disclosure of agents' private information through the preopening pricing phase. Our findings reveal a positive relationship between the preopening price and the prices traded during the subsequent phase, alongside a decreased deviation of prices from their fundamental value when high‐quality information is available. These results suggest that a well‐defined preopening phase has the potential to improve market efficiency.
Variation in immune response in the generalist herbivore fall webworm across four common host plants
Authors: Mitchell Audrey M. , Vyas Dhaval K. , Murphy Shannon M. 
Published: August 2024

AbstractDietary generalist herbivorous insects are widespread and often occur in a variety of environments. Across their geographic range, herbivorous insects may encounter variable plant traits as they feed on high‐quality or low‐quality plants. Herbivorous insect larvae experience both bottom‐up (host plant) and top‐down (parasitoid) factors that affect survival. Host plant quality may affect larval growth and survival in that larvae feeding on low‐quality plants often suffer reduced fitness. However, herbivores on different host plants are also subject to different levels of parasitism. High‐quality plants confer stronger larval performance (higher survival, more offspring), but larvae may also face higher parasitism. In some herbivore species, diet mediates larval immune response. The generalist insect herbivore fall webworm (FW), Hyphantria cunea Drury (Lepidoptera: Erebidae), is a moth native to North America, and its larvae have considerable variance in their performance when reared on different host plants. We investigated whether diet affects the immune response in FW larvae when they are reared on different host plant species known to vary in food quality. We measured immune response by melanization of a nylon filament. We found significant differences in immune response across host plants, indicating that diet mediates immune response in FW larvae. Our study helps elucidate the factors that cause variation in immune response in a generalist herbivore.
A widespread, consistent, and perplexing biphasic pattern in log catch‐at‐age data from a widely harvested family of tropical reef fishes
Authors: Taylor Brett M. , Prince Jeremy , Mutz Stephanie , Pardee Cassandra , Wiley John , Robertson D. Ross , Choat J. Howard 
Published: August 2024

AbstractPatterns of cohort decline are key demographic traits that provide a unique temporal perspective vital to understanding population dynamics. The discovery of multidecadal lifespans in tropical surgeonfishes in the 1990s created a paradigm shift to the notion that they are highly vulnerable species with low population recovery rates; however, research into the mortality patterns of surgeonfishes (Acanthuridae) has been sparse until recently. Recent studies on this family have demonstrated an unusual (possibly unique), two‐phase pattern of adult catch‐at‐age, whereby there is a population‐level shift from higher‐than‐expected rates of decline early in life to lower‐than‐expected decline rates for the remainder of the lifespan. To examine the geographic and phylogenetic ubiquity of this pattern, we compiled age‐based information from demographic samples of 70 populations of 25 tropical species spanning the Indo‐Central Pacific and Central‐Western Atlantic. Overall, we found that 79% of populations exhibited strong biphasic patterns, including 88% of populations across the Indo‐Central Pacific. By accounting for empirical relationships instead of using linear catch curves or classical assumptions of natural population decay based on lifespan, we demonstrate that surgeonfishes have turnover times that are two to four times faster than previously believed. Faster turnover times may suggest a higher level of sustainability for surgeonfish fisheries throughout the global tropics than previously estimated.