bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unusual Clinical Features of Cutaneous Tuberculosis in an Immune Compromised Patient
Authors: Tanaka Asayo , Kato Yukihiko , Arai Keitaro , Oh‐i Tsunao , Koga Michiyuki 
Published: July 2014

AbstractWe report a case of an unusual form of cutaneous tuberculosis in an 82‐year‐old woman. She visited our hospital because of an intractable ulcer on the fifth finger of her right hand. While examining the ulcer surrounding half of her right fifth finger and covered with necrotic tissue, we also perceived a nodule with crust on the forearm, multiple subcutaneous nodules on the right forearm and upper arm, and a hen's‐egg‐sized agglomerative nodule on the axilla. All the lesions were located on her right arm. Skin biopsy specimens showed granulomatous tissue with necrosis in the lesions. Mycobacterium tuberculosis was identified by culture of a biopsied specimen, so the diagnosis was confirmed. Further examination revealed that she also had pulmonary tuberculosis. Cutaneous tuberculoses are classified morphologically with reference to host immune status, but no satisfactory classification exists. The present case can't be classified into any of the types which have been proposed so far. She is elderly and suffers from liver cirrhosis, hepatocellular carcinoma and myelodysplastic syndrome. The resulting acquired immunosuppression may have caused a unique form of cutaneous tuberculosis.
Proteus Syndrome
Authors: Roma Pandhi , Murlidharn R , Kumar Bhushan 
Published: July 2014

AbstractProteus syndrome is a rare congenital hamartomatous entity. We report some new findings in a boy with this syndrome, in addition to the classical clinical and radiological features of subcutaneous masses, partial gigantism of hands and feet, bony abnormalities, and epidermal nevi. We also discuss how to reach a difinitive diagnosis by using an established rating scale.
Report of Eight Infants with Acute Infantile Hemorrhagic Edema and Review of the Literature
Authors: Çaksen Hüseyin , Odabaş Dursun , Kösem Mustafa , Arslan Şükrü , Öner Ahmet Faik , Ataş Bülent , Akçay Gürbüz , Ceylan Nesrin 
Published: July 2014

AbstractAcute infantile hemorrhagic edema (AIHE) is a cutaneous leukocytoclastic vasculitis, clinically characterized by the symptom triad of fever, large purpuric skin lesions, and edema. The clinical picture has a violent onset, a short benign course, and spontaneous complete recovery. In this article, we present eight patients who were admitted with rashes on the skin and edema on the eyelids and extremities, and were diagnosed with AIHE according to their clinical and histopathological features (immunohistological study was also performed in three of them). Our purpose was to emphasize that, aside from Henoch‐Schönlein purpura, meningococcemia, septicemia, and purpura fulminans, AIHE benign disorder should also be considered in the differential diagnosis to determine the clinical course and treatment protocol in patients with purpuric rashes.
Papillon‐Lefevre Syndrome: A Case Report
Authors: Pratchyapruit Walai‐orn , Kullavanijaya Preya 
Published: July 2014

AbstractWe report the first diagnosed case of Papillon‐Lefevre syndrome in Thailand. The patient is the youngest child of consanguinous parents, and she has had symmetrical hyperkeratotic plaques on both plantar surfaces since birth with a history of chronic gingivitis, periodontitis, and premature loss of primary dentition. The histologic study revealed compact hyperkeratosis with epidermal acanthosis. Radiologic studies of the skull were normal. The radiographic panoramic view of the oral cavity revealed generalized severe vertical and horizontal alveolar bone loss. The immunologic analysis of polymorphonuclear leukocyte phagocytic function by nitrobluetetrazolium test (NBT test) showed decreasing response to latex stimulation. Serum parathyroid hormone, calcium, phosphate, and alkaline phosphatase levels were within normal limits. The skin lesions were temporary relieved with topical keratolytic agents. The oral lesions were improved by the extraction of hopeless teeth and conventional periodontal treatments.
Diffuse Cutaneous Mastocytosis: Pseudoxanthomatous Variant
Authors: Jain Rajesh , Dogra Sunil , Verma Shikha , Mohanty Sambit K , Handa Sanjeev 
Published: July 2014

AbstractDiffuse cutaneous mastocytosis is one of the extremely rare benign forms of mastocytosis that have varied clinical presentations. The pseudoxanthomatous variant is an extremely rare multinodular nonpigmented entity. Only two cases have been reported so far in the literature. We report a 21 year old female patient who had diffusely infiltrated skin with multiple papulo‐nodular lesions resembling xanthomas and the classical histopathological features of mastocytosis.
Perianal Ulceration in a “Healthy” Chinese Man with Disseminated Tuberculosis
Authors: Ho Man Hon , Lee King Chung , Chong Lai Yin 
Published: July 2014

AbstractOrificial tuberculosis (OTB) is a rare form of cutaneous Mycobacterium tuberculosis infection affecting the mucosa and skin around orifices in patients with advanced internal tuberculosis and poor general health. We report a 72‐year‐old Chinese man who had a 10‐year history of OTB with disseminated tuberculosis infection of the lungs and urinary tract. He appeared surprisingly healthy and had been free from systemic symptoms all along despite widespread tuberculosis. The diagnosis of OTB was established by the microscopic presence of acid‐fast bacilli (AFB) in the tissue section and was rapidly confirmed by polymerase chain reaction (PCR) to be Mycobacterium tuberculosis. PCR shortens the time of diagnosing rare presentations of cutaneous tuberculosis and prevents delays in treatment. Conventional culture is still important in confirming the diagnosis and screening for drug resistance.
Unilateral Generalized Morphea in Childhood
Authors: Nagai Yayoi , Hattori Tomoyasu , Ishikawa Osamu 
Published: July 2014

AbstractWe report a 6‐year‐old boy with unilateral generalized morphea distributing on the right side of his lower leg, trunk, and upper arm. A skin biopsy from the right thigh showed accumulation of thick collagen bundles extending from the middle dermis to the subcutaneous fat tissue. The levels of antinuclear antibodies, rheumatoid factor, and anti single‐stranded DNA antibody were elevated. No severe deformity or functional disabilities were noted. With topical corticosteroid therapy, the sclerotic skin became gradually softer, and no progression of sclerosis has been noted for one year.
Inhibition of the Proliferation of a Malignant Peripheral Nerve Sheath Tumor Cell Line by Gamma Interferon Gene Transfection
Authors: Nakayama Juichiro , Tanaka Toshihiro , Furumura Minao , Takahashi Akira , Yamaguchi Takahiro , Shimura Hideo , Ikeda Seiyo , Kuroki Masahide 
Published: July 2014

AbstractA solitary malignant peripheral nerve sheath tumor was resected, and a tumor cell line was obtained using an explant culture. The morphology of this cell line was quite similar to those of cell lines of dermal neurofibromas of neurofibromatosis 1, except for the fact that the malignant peripheral nerve sheath tumor cell line could be cultured for more than two months. When the tumor cell line was transfected with human gamma interferon gene, the growth rate was remarkably abolished, as previously observed in neurofibroma cell lines transfected with the gamma interferon gene. This new finding suggests the potential for treating either solitary or neurofibroma‐related, inoperable, malignant peripheral nerve sheath tumors by local gamma interferon gene transfection in vivo.
Weight Loss‐Induced Calciphylaxis: Potential Role of Matrix Metalloproteinases
Authors: Munavalli Girish , Reisenauer Amy , Moses Marsha , Kilroy Susan , Arbiser Jack L. 
Published: July 2014

AbstractCalciphylaxis is an uncommon and often devastating syndrome of calcification of small vessels, leading to tissue infarction. The mechanism of how calcium deposits on small vessels is unknown. Recently, metalloproteinase digestion of elastin has been shown to enhance deposition of calcium, suggesting a possible mechanism of calciphylaxis. We describe a case of a patient who developed calciphylaxis after rapid weight loss, but had normocalcemia and normal renal function. She was found to have high levels of matrix metalloproteinases, which may have chemically altered elastin, allowing deposition of calcium on small vessels. Inhibitors of matrix metalloproteinases may be useful in the prevention and treatment of calciphylaxis.
Lupoid Sycosis of Pubic Area
Authors: Manchanda Yashpal , Khanna Neena , Pandhi Ravinder Kumar , Das Sudip , Sirka Chander Shekhar 
Published: July 2014

AbstractLupoid sycosis is a rare cicatricial form of chronic folliculitis commonly seen in men after puberty. It usually involves the beard area and is refractory to treatment. We here report two cases of lupoid sycosis; one had additional involvement of the pubic area. Both patients showed complete clearance with minocycline.
Negative‐Pressure Dressings in the Treatment of Pressure Ulcers
Authors: Isago Tsukasa , Nozaki Motohiro , Kikuchi Yuji , Honda Takashi , Nakazawa Hiroaki 
Published: July 2014

AbstractApplying negative pressure to wounds may speed the formation of granulation tissue, decrease the amount of localized edema, increase blood flow, and accelerate healing. In the present study, we treated ten patients with stage IV chronic pressure ulcers using this negative pressure dressing technique. The long (A) and short (B) diameters of each ulcer were measured to determine size, and the vertical distance from the skin to the deepest point of the ulcer was measured to determine depth. Lesions were measured initially and at weekly intervals. The area of each lesion was taken to be 3.14 x A/2 x B/2 (cm2). When we compared the area of ulcer before and after the treatment, the area had been reduced in all cases, and the average reduction was 55.1%. The depth of ulcer also decreased in all cases, and the average reduction was 61.2%. Over the period of evaluation, the method was considered markedly effective in reducing the size and depth of ulcers.
Disseminated Cytomegalovirus Disease as a Cause of Prolonged Fever in a Bullous Pemphigoid Patient under Systemic Steroid Therapy
Authors: Casals Daniel Sesto , Nunes Eduardo de Azevedo , Maruta Celina Wakisaka , Aoki Valeria , Santi Claudia Giuli , Nico Marcello Menta Simonsen , Correa Maria Cassia Mendes , Leite Olavo Henrique Munhoz , Rivitti Evandro A. 
Published: July 2014

AbstractWe present the first reported case of disseminated cytomegalovirus (CMV) in association with prednisone therapy in bullous pemphigoid (BP). A 66‐year‐old black male patient was admitted to our hospital presenting cutaneous pruritic lesions represented by tense blisters, with serous content on the arms, abdomen and legs. Laboratory findings confirmed the diagnosis of BP. After two weeks of prednisone therapy, the patient developed prolonged fever, which was caused by CMV disseminated disease, with prompt clinical recovery after ganciclovir administration.
Hydroa Vacciniforme‐like Eruptions in a Patient with Chronic Active EB Virus Infection
Authors: Katagiri Yoshiyuki , Mitsuhashi Yoshihiko , Kondo Shigeo , Kanazawa Chikako , Iwatsuki Keiji , Tsunoda Takahiko 
Published: July 2014

AbstractWe report a case of chronic active Epstein‐Barr (EB) virus infection (CAEBV) associated with skin eruptions mimicking hydroa vacciniforme (HV) in a 4‐year‐old boy. The patient had repeated episodes of vesiculo‐necrotic eruptions on the face, scalp, and bilateral forearms one year before the first visit to our department. General symptoms including fever, hepatosplenomegaly, abnormal liver function, and cervical lymph node swelling were noted three months before the first visit. At the first visit, small, bean‐sized, erythemic papules with central necrosis were observed on the face and anterior chest wall. Thumb‐sized ulcers with crust were present on the bilateral forearms. Histopathological examination of an erythematous lesion in the submandibular area revealed parakeratosis with a thick crust, mild spongiosis in the epidermis, and a dense infiltration of lymphoid cells into the dermis and perivascular space. Laboratory examination showed EBNA x40, EBV VCA IgG x 1,280, and EBV DNA (PCR) 8 times 104. EBV‐encoded small nuclear RNA (EBER) positive cells were detected in the dermis by an in situ hybridization (ISH) method. Large granular lymphocytes (65%) with the NK cell phenotype were found in the peripheral blood. A real time PCR method showed 171,741 copies/μg DNA in CD 16 positive cells. Although latent EBV infection‐associated eruptions have been documented, detailed skin manifestations in CAEBV are less well known.
Oral Ivermectin Treatment in Two Cases Of Scabies: Effective in Crusted Scabies Induced by Corticosteroid but Ineffective in Nail Scabies
Authors: Ohtaki Noriko , Taniguchi Hiroko , Ohtomo Hiroshi 
Published: July 2014

AbstractWe report two cases of scabies treated with oral ivermectin (200 μg/kg). Case 1, a 72‐year‐old man, developed crusted scabies with the use of oral corticosteroids due to a misdiagnosis by an earlier physician. The patient was successfully treated with two doses of oral ivermectin at a 7 day interval with concomitant topical use of crotamiton and keratolytic agents. However, the nail scabies in this patient failed to respond to these treatments. Live mites were detected from all his toenails two weeks after the second dose of ivermectin. A complete cure of the nail scabies was achieved by occlusive dressing of 1% γ‐BHC on all toenails for one month. Case 2, a 52‐year‐old woman, had been treated with oral corticosteroid for mesangial nephritis. She developed common scabies, but a topical scabicide, crotamiton, was not effective. Two weeks after treatment with a single dose of oral ivermectin, eggs were still detected from a burrow on her trunk. Her treatment was completed after a further two doses of oral ivermectin were administered at 7 day intervals. In both patients, the administration of oral ivermectin did not induce any clinical or laboratory side effects. Oral ivermectin is effective for crusted scabies, but not effective for nail scabies. Two doses of oral ivermectin, administered with a one‐week interval, is an appropriate treatment regimen.
Treatment of Persistent Severe Atopic Dermatitis in 113 Japanese Patients with Oral Psoralen Photo‐Chemotherapy
Authors: Uetsu Naoko , Horio Takeshi 
Published: July 2014

AbstractOral administration of psoralen and whole body exposure to UVA (oral PUVA) has been used for the treatment of 113 patients with severe atopic dermatitis (AD). 8‐Methoxypsoralen (8‐MOP) was given at a dose of 0.5–0.6 mg/kg two hours prior to UVA (3‐8 J/cm2) irradiation. Patients were treated three times a week while hospitalized. Other medications which had been given before PUVA therapy were permitted. At four and eight weeks after PUVA therapy, the severity score of AD had decreased by 51% and 80%, and the cumulative doses of UVA were 51.2 J/cm2 and 115.3 J/cm2, respectively. The amounts and strength of topical cortico‐steroids were decreased during PUVA therapy. No adverse effects that required discontinuation of the PUVA therapy were observed. After discharge, maintenance therapy with UVB phototherapy and/or conventional treatment of AD kept the patients in remission in the outpatient clinic. The QOL of patients was greatly improved. Photochemotherapy with oral 8‐MOP can be indicated in patients with severe, widespread AD, especially if standard therapy fails. This is the first report of oral PUVA therapy in a large series of Japanese patients with AD.
Pharmacological Profiles of High‐Concentration (20 μg/g) Tacalcitol Ointment: Effects on Cutaneous Inflammation, Epidermal Proliferation, and Differentiation in Mice
Authors: Sato Hiroaki , Ogino Yasuhiro , Takagi Hideko , Hata Junko , Asano Satoshi , Ohta Tomohiro , Komoriya Keiji 
Published: July 2014

AbstractThis study focused on the effects of tacalcitol (1,24(R)(OH)2D3, TV‐02) ointment (20 μg/g) on cutaneous inflammation, epidermal proliferation, and differentiation and compared them with tacalcitol ointment (2 μg/g) and other anti‐psoriatic ointments using hairless mice. Tacalcitol ointment (0, 2 and 20 μg/g) significantly inhibited 12‐O‐tetradecanoylphorbol 13‐acetate (TPA)‐induced cutaneous inflammation, histopathologically. The effect of tacalcitol ointment (20 μg/g) on cutaneous inflammation was much stronger than that of tacalcitol ointment (0, 2 μg/g), and as effective as calcipotriol ointment (50 μg/g) or betamethasone valerate ointment (1.2 mg/g). Tacalcitol ointment (20 μg/g) also significantly inhibited TPA‐induced myeloperoxidase (MPO) activity, as effectively as calcipotriol ointment (50 μg/g) or betamethasone valerate ointment (1.2 mg/g). The effect of tacalcitol ointment on epidermal proliferation [ornithine decarboxylase (ODC) activity] and differentiation [transglutaminase (TGase) activity] was dose‐dependent from 0 μg/g to 20 μg/g. The effect of tacalcitol ointments on epidermal proliferation was significant at the doses of 2 μg/g and 20 μg/g, and that on epidermal differentiation was significant at the doses of 0.2 μg/g or more. The effect of tacalcitol ointment (20 μg/g) on epidermal differentiation was significantly stronger than tacalcitol ointment (2 μg/g). In this study, tacalcitol ointment (20 μg/g) was found to have a marked effect on cutaneous inflammation and improved effect on epidermal differentiation, although tacalcitol ointment (2 μg/g) also had significant effects on epidermal proliferation and differentiation. These findings support the clinical effectiveness of tacalcitol ointment (20 μg/g) against psoriasis.
Dyshidrosiform Pemphigoid: Report of a Case
Authors: Sugimura Chieko , Katsuura Junko , Moriue Tetsuya , Matsuoka Yoshie , Kubota Yasuo 
Published: July 2014

AbstractA Japanese woman had bullous eruptions on her palms and soles for two months, histopathologic examination, immunofluorescence microscopy, and ELISA for BP180 antigen led to the definitive diagnosis of dyshidrosiform pemphigoid (DP). This paper also includes a study of 15 other cases of DP.
The Pattern of Mucocutaneous Infections and Infestations in Renal Transplant Recipients
Authors: Sandhu Kamaldeep , Gupta Somesh , Kumar Bhushan , Dhandha Raman , Udigiri Naval Kishore , Minz Mukut 
Published: July 2014

AbstractImmunosuppression‐related mucocutaneous lesions are a significant problem in renal transplant recipients. Infections account for the majority of these manifestations. The aim of this study was to determine the spectrum of mucocutaneous infections and infestations in renal transplant recipients. Over a period of three years, all the renal transplant recipients presenting with mucocutaneous lesions (only with infectious etiology) were included in the study. Diagnosis was based on the clinical appearance and appropriate investigations like scraping for KOH, Tzanck smear, cultures, and skin biopsies whenever necessary. In order to study the temporal effect of immunosuppression on these mucocutaneous infections, the patients were divided into six groups—with durations of graft survival ranging from 0–2, 2–6, 6–12, 12–24, 24–60, and more than 60 months in Groups A–F, respectively. A total of 104 renal transplant recipients presented with 117 infections and infestations. The mean age at presentation was 35.9 ± 1.2 years (15–65yrs), and the mean duration after the transplant was 23.3 ± 3.5 months (1–175). The mean serum creatinine level at the time of clinical presentation was 1.4 ± 0.07 mg/dl (0.7–6). Twenty‐seven patients were on a two‐drug regimen, prednisolone and azathioprine, and the rest were on a three‐drug regimen with cyclosporine in addition. Out of the total of 117 infections in 104 patients, 57 were viral, 49 were fungal, and 8 were bacterial. Two patients had scabies and one had cysticercosis. The mean time interval for the occurrence of infections after the transplant was earlier in patients on three‐drug immunosuppression (12.4 ± 2.3 months) than in those on the two‐drug regimen (51.3 ± 1.8 months), (p<0.01). The viral infections had the shortest mean time interval for presentation following transplant, 15.8 ± 1.2 months (p<0.05). We did not find any statistically significant difference with regard to age or sex of the patients, duration after the transplant, or the pattern of infection. Careful examination of transplant patients is essential for early detection and proper treatment, because the mucocutaneous infections can have atypical morphologies and are likely to become extensive if not treated early.
Pemphigus in Korea: Clinical Manifestations and Treatment Protocol
Authors: Seo Pan Gyo , Choi Won Woo , Chung Jin Ho 
Published: July 2014

AbstractPemphigus, a rare, chronic blistering disease of the skin and mucous membranes with severe morbidity and occasional mortality, is the most common autoimmune bullous disease in Korea. The purpose of this study was to evaluate the clinical features and propose a treatment strategy for patients with pemphigus. A retrospective analysis was conducted of 51 pemphigus patients seen between 1993 and 2001. Pemphigus vulgaris (PV) was the most common type with 32 cases, followed by 19 cases of pemphigus foliaceus (PF). The male to female ratio was 1:1.3, with females predominating, particularly among PV patients (PV, 1:1.5; PF, 1:1.1). The average ages at onset of PV and PF were 44.3 and 51.0 years old, respectively. Mucosal involvement was noted in 27 cases (84.4%) of PV but in only 3 cases (15.8%) of PF. Most patients initially received relatively low to intermediate doses (0.3–1.0 mg/kg/day) of prednisolone, and 23 (71.9%) PV patients and 10 (52.6%) PF patients also received immunosuppressive agents. Oral prednisolone and azathioprine (100 mg/day) formed the mainstay of treatment for our patients (47.1%). At the time of writing, 25.5% (13/51) of patients are in complete remission, and 72.5% (37/51) are undergoing maintenance therapy. One patient died due to sepsis during the treatment. For the treatment of pemphigus, a course of the lowest possible corticosteroid dosage in combination with immunosuppressive agents appears to be effective and less toxic than a high corticosteroid dosage.
Clinical Evaluation of Roxithromycin: A Double‐Blind, Placebo‐Controlled and Crossover Trial in Patients with Acne Vulgaris
Authors: Ferahbas Ayten , Utas Serap , Aykol Deniz , Borlu Murat , Uksal Umit 
Published: July 2014

AbstractWe clinically evaluated roxithromycin (ROM) in a double blind, placebo‐controlled, and crossover trial in patients with inflammatory acne. Patients with inflammatory acne who were attending our outpatient clinic for treatment and who had not received topical or systemic treatment for the previous month were enrolled in this study. Patients were randomly separated into two groups. Group I consisted of 26 patients. The patients received 2 × 150 mg/day ROM orally in the first period and 2 × 1 placebo tablets/day in the second period. Group II consisted of 20 patients. These patients received 2 × 1 placebo tablets/day in the first period and 2 × 150 mg/day ROM orally in the second period. The first period was the first four weeks, and then there was a washout period of two weeks (5th and 6th). The second period was the next four weeks (7th to 10th weeks) after the washout period. Median acne scores had clearly decreased in both groups at the end of the study. Differences of median acne scores were statistically significant in both groups between at baseline and at the end of the study (p< 0.001). The results showed that ROM is a safe and effective alternative in the treatment of inflammatory acne with few side effects and good compliance.