bluuebunny/crossref_metadata_2025_split huggingface dataset:
Schnitzler's syndrome: lessons from 281 cases
Authors: de Koning Heleen D 
Published: December 2014

AbstractSchnitzler's syndrome is an autoinflammatory disorder characterized by the association of a monoclonal IgM (or IgG) gammopathy, a chronic urticarial rash, and signs and symptoms of systemic inflammation, including fever, arthralgias and bone pain. It was first described in 1972. This review summarizes the clinical features, efficacy of therapies, and follow‐up data of the 281 cases that have been reported to date. Also, the results of skin histology, bone imaging, laboratory investigations, and studies of the pathogenesis will be discussed, including the pivotal role of interleukin‐1 beta in this disorder.
The impact of land use and cover change on above and below-ground carbon stocks of the miombo woodlands since the 1950s: a systematic review protocol
Authors: Syampungani Stephen , Clendenning Jessica , Gumbo Davison , Nasi Robert , Moombe Kaala , Chirwa Paxie , Ribeiro Natasha , Grundy Isla , Matakala Nalukui , Martius Christopher , Kaliwile Moka , Kabwe Gillian , Petrokofsky Gillian 
Published: December 2014

AbstractBackgroundIncreasingly, forests are on the international climate change agenda as land use and cover changes drive forest and carbon loss. The ability of forests to store carbon has created programs such as Reducing Emissions from Deforestation and Degradation plus (REDD+), in order to provide incentives for particular land uses and forest management practices. A critical element to REDD+ is the ability to know the carbon-storage potential of an ecosystem, and the factors likely to affect the rate of carbon accumulation or the maximum amount stored. Most REDD+ initiatives have focused on humid tropical forests because of their large stocks per unit area. Less attention has been paid to the carbon-storage potential of tropical dry forests, woodlands and savannas. Although these ecosystems support a lower biomass per unit area, they are more widespread than humid forests. This proposed systematic review examines miombo woodlands, which are the most extensive vegetation formation in Africa and support over 100 million people. We ask: To what extent have changes in land use and land cover influenced above- and below-ground carbon stocks of miombo woodlands since the 1950s?MethodsWe will search systematically for studies that document the influence of land use and cover change on above and below ground carbon in miombo woodlands since the 1950s. We will consult bibliographic databases and an extensive grey literature network, including government reports and forestry offices. Relevant studies will examine the impacts of human activities, fire and other land use or cover changes that affect wood biomass or soil carbon in the miombo region. All included studies will be assessed for the soundness and scientific validity of their study design. A quantitative synthesis will tabulate estimates of various parameters necessary to assess carbon stocks and changes across climate and geological factors; and a qualitative analysis will describe the governing land and forest policies. Understanding the impact that land uses and the associated changes have on carbon storage in the miombo woodlands will contribute to more informed forest management policies and better guided strategies for the United Nations Framework Convention on Climate Change.
Progesterone receptor activation downregulates GATA3 by transcriptional repression and increased protein turnover promoting breast tumor growth
Authors: Izzo Franco , Mercogliano Florencia , Venturutti Leandro , Tkach Mercedes , Inurrigarro Gloria , Schillaci Roxana , Cerchietti Leandro , Elizalde Patricia V , Proietti Cecilia J 
Published: December 2014

Abstract
Introduction
The transcription factor GATA3 is involved in mammary gland development and is crucial for the maintenance of the differentiated status of luminal epithelial cells. The role of GATA3 in breast cancer as a tumor suppressor has been established, although insights into the mechanism of GATA3 expression loss are still required.

Methods
Chromatin immunoprecipitation assays were conducted to study progestin modulation of recruitment of transcription factors to GATA3 promoter. We performed western blot and reverse RT-qPCR experiments to explore progestin regulation of GATA3 protein and mRNA expression respectively. Confocal microscopy and in vitro phosphorylation studies were conducted to examine progestin capacity to induce GATA3 serine phosphorylation in its 308 residue. GATA3 participation in progestin-induced breast cancer growth was addressed in in vitro proliferation and in vivo tumor growth experiments.

Results
In this study, we demonstrate that progestin-activated progesterone receptor (PR) reduces GATA3 expression through regulation at the transcriptional and post-translational levels in breast cancer cells. In the former mechanism, the histone methyltransferase enhancer of zeste homolog 2 is co-recruited with activated PR to a putative progesterone response element in the GATA3 proximal promoter, increasing H3K27me3 levels and inducing chromatin compaction, resulting in decreased GATA3 mRNA levels. This transcriptional regulation is coupled with increased GATA3 protein turnover through progestin-induced GATA3 phosphorylation at serine 308 followed by 26S proteasome-mediated degradation. Both molecular mechanisms converge to accomplish decreased GATA3 expression levels in breast cancer cells upon PR activation. In addition, we demonstrated that decreased GATA3 levels are required for progestin-induced upregulation of cyclin A2, which mediates the G1 to S phase transition of the cell cycle and was reported to be associated with poor prognosis in breast cancer. Finally, we showed that downregulation of GATA3 is required for progestin stimulation of both in vitro cell proliferation and in vivo tumor growth.

Conclusions
In the present study, we reveal that progestin-induced PR activation leads to loss of GATA3 expression in breast cancer cells through transcriptional and post-translational regulation. Importantly, we demonstrate that GATA3 downregulation is required for progestin-induced upregulation of cyclin A2 and for progestin-induced in vitro and in vivo breast cancer cell growth.
Sex Differences in Biomarkers Associated With Insulin Resistance in Obese Adolescents: Metabolomic Profiling and Principal Components Analysis
Authors: Newbern Dorothee , Gumus Balikcioglu Pinar , Balikcioglu Metin , Bain James , Muehlbauer Michael , Stevens Robert , Ilkayeva Olga , Dolinsky Diana , Armstrong Sarah , Irizarry Krystal , Freemark Michael 
Published: December 2014

Objective
Obesity and insulin resistance (IR) predispose to type 2 diabetes mellitus. Yet only half of obese adolescents have IR and far fewer progress to type 2 diabetes mellitus. We hypothesized that amino acid and fatty acid metabolites may serve as biomarkers or determinants of IR in obese teens.

Research Design and Methods
Fasting blood samples were analyzed by tandem mass spectrometry in 82 obese adolescents. A principal components analysis and multiple linear regression models were used to correlate metabolic components with surrogate measures of IR: homeostasis model assessment index of insulin resistance (HOMA-IR), adiponectin, and triglyceride (TG) to high-density lipoprotein (HDL) ratio.

Results
Branched-chain amino acid (BCAA) levels and products of BCAA catabolism were higher (P &lt; .01) in males than females with comparable body mass index (BMI) z-score. In multivariate analyses, HOMA-IR in males correlated positively with BMI z-score and a metabolic signature containing BCAA, uric acid, and long-chain acylcarnitines and negatively with byproducts of complete fatty acid oxidation (R2 = 0.659, P &lt; .0001). In contrast, only BMI z-score correlated with HOMA-IR in females. Adiponectin correlated inversely with BCAA and uric acid (R2 = 0.268, P = .0212) in males but not females. TG to HDL ratio correlated with BMI z-score and the BCAA signature in females but not males.

Conclusions
BCAA levels and byproducts of BCAA catabolism are higher in obese teenage boys than girls of comparable BMI z-score. A metabolic signature comprising BCAA and uric acid correlates positively with HOMA-IR in males and TG to HDL ratio in females and inversely with adiponectin in males but not females. Likewise, byproducts of fatty acid oxidation associate inversely with HOMA-IR in males but not females. Our findings underscore the roles of sex differences in metabolic function and outcomes in pediatric obesity.
Is 18F-Fluorocholine-Positron Emission Tomography/Computerized Tomography a New Imaging Tool for Detecting Hyperfunctioning Parathyroid Glands in Primary or Secondary Hyperparathyroidism?
Authors: Michaud Laure , Burgess Alice , Huchet Virginie , Lefèvre Marine , Tassart Marc , Ohnona Jessica , Kerrou Khaldoun , Balogova Sona , Talbot Jean-Noël , Périé Sophie 
Published: December 2014

Context:Preoperative ultrasonography and scintigraphy using 99mTc-sestamibi are commonly used to localize abnormal parathyroid glands. In cases of discrepant results between scintigraphy and ultrasonography, it is important to rely on another diagnostic imaging modality. 18F-fluorodeoxyglucose (FDG) and 11C-methionine positron emission tomography (PET) have been studied, but are imperfect to detect abnormal parathyroid glands. Recently, first cases of abnormal parathyroid glands taking-up radiolabelled choline were discovered incidentally in men referred to 11C-choline or 18F-fluorocholine (FCH)-PET/CT for prostate cancer. We checked if FCH uptake was a general feature of adenomatous or hyperplastic parathyroid glands.Methods:FCH-PET/CT was performed in 12 patients with primary (n = 8) or secondary hyperparathyroidism (1 dialyzed, 3 grafted) and with discordant or equivocal results on preoperative ultrasonography (US) and/or 123I/99mTc-sestamibi dual-phase scintigraphy. The results of the FCH-PET/CT were evaluated, with surgical exploration and histopathologic examination as the standard of truth.Results:On a per-patient level, the detection rate of FCH-PET/CT (at least one FCH focus corresponding to an abnormal parathyroid gland in a given patient) was 11/12 = 92%. FCH-PET/CT detected 18 foci interpreted as parathyroid glands and correctly localized 17 abnormal parathyroid glands (7 adenomas and 10 hyperplasias). On a per-lesion level, FCH-PET/CT results were 17 TP, 2 false negative ie, a lesion-based sensitivity of 89%, and 1 false positive.Conclusion:As the main result of this pilot study, we show that in patients with hyperparathyroidism and with discordant or equivocal results on scintigraphy or on ultrasonography, adenomatous or hyperplastic parathyroid glands can be localized by FCH-PET/CT with good accuracy. Furthermore, FCH-PET/CT can solve discrepant results between preoperative ultrasonography and scintigraphy and has thus a potential as a functional imaging modality in the detection of abnormal parathyroid glands. Our preliminary results are encouraging and prompt us to further evaluate FCH-PET/CT as a functional imaging agent in patients with biochemical hyperparathyroidism.
Preparation of Carbon Nanofibers by Hydrogenation of Carbon Dioxide on a Nickel Sponge Catalyst
Authors: Wu Naijin , Li Baoshan , Zhang Jie 
Published: December 2014

Abstract
A novel method for preparing carbon nanofibers via catalytic hydrogenation of CO2 on a nickel sponge catalyst at 773 K and under atmospheric pressure is reported. The drop of pressure on the nickel sponge catalyst was small, which revealed that it could save on energy for the preparation of the carbon nanofibers. The diameter of the products was less than 200 nm.
Cooperative Catalysis of p-Aminophenol and Titanocene Dichloride in Direct Mannich Reactions with Acetone
Authors: Zhu Xuyang , Chen Chun , Yu Binxun , Zhang Guofang , Zhang Weiqiang , Gao Ziwei 
Published: December 2014

Abstract
A new binary acid system featuring an air stable organometallic precursor, titanocene dichloride and a simple Brønsted acid–base compound, was developed. The new catalyst system allowed for mild and highly efficient direct three-component Mannich reactions of both aryl ketones and alkyl ketones, in particular, acetone and its derivatives with excellent yields. Mechanistic study elucidated the dramatic synergistic effect of the new binary acid system.
Enhanced Magnetoelastic Behavior of Magnetic Elastomers with Layered Structure
Authors: Oguro Tsubasa , Kanauchi Shunta , Mitsumata Tetsu , Tamesue Shingo , Yamauchi Takeshi 
Published: December 2014

Abstract
We synthesized layered magnetic elastomers with polymer films and investigated the magnetoelastic behavior using dynamic viscoelastic measurements. The storage modulus at 0 mT was nearly independent of the sheets of films, while the storage modulus at 500 mT dramatically increased. The storage modulus at 500 mT for magnetic elastomers with 4 films was 2.1 MPa, which was 1.3 MPa higher than that of magnetic elastomers without layered structure. It can be considered that the stress transfer among imperfect short chains of magnetic particles is enhanced by inserting polymer films.
Simultaneous Determination of Linalool, Ambrox, and Sclareolide in Clary Sage Oil by GC-MS
Authors: Xu Yang-Bin , Wang Kai , Zhu Rui-Zhi , Zhe Wei , Li Zhi-Yu 
Published: December 2014

Abstract
The volatile components of clary sage oil were identified by gas chromatography/time-of-flight mass spectrometry (GC-TOFMS). The peak area normalization method was used to calculate the relative content of the components. With the MS library search, 32 compounds, which account for 91.24% in the volatile components of clary sage oil, were confirmed by using retention index. A rapid and effective GC-MS method for simultaneous determination of linalool, ambrox, and sclareolide in clary sage oil has been developed. Three samples were used for method evaluation. The relative standard deviations (RSD) were &lt;4% for linalool, ambrox, and sclareolide. The limits of detections (LOD) were 80, 50, and 150 µg L−1 for linalool, ambrox, and sclareolide, respectively. The recoveries were 90–109% for linalool, 91–105% for ambrox, and 94–103% for sclareolide. The method could be applied to measure linalool, ambrox, and sclareolide in clary sage oil.
Photocatalytic Water Splitting over Rod-shaped K3Ta3Si2O13 and Block-shaped Ba3Ta6Si4O26 Prepared by Flux Method
Authors: Takayama Tomoaki , Iwase Akihide , Kudo Akihiko 
Published: December 2014

Abstract
K3Ta3Si2O13 and Ba3Ta6Si4O26 particles prepared by a flux method using KCl possessed well-crystallized nanorod and block shapes, respectively. The K3Ta3Si2O13 and Ba3Ta6Si4O26 with one-dimensional and linear pillared structure showed photocatalytic activities for water splitting. The quantum yields were 2.4% and 0.2% at 254 nm for NiO/K3Ta3Si2O13 and NiO/Ba3Ta6Si4O26, respectively. The difference in the photocatalytic activity was related to the degree of distortion of the one-dimensional pillared structure.
A New Rhodamine-based Fluorescent Probe for the Detection of Singlet Oxygen
Authors: Yu Hui , Liu Xi , Wu Qingfeng , Li Qiang , Wang Shuai , Guo Yong 
Published: December 2014

Abstract
A new probe specific for singlet oxygen (1O2) was designed by incorporating the reactive anthracene moiety into a rhodamine fluorophore. The new probe displayed selective and sensitive response to 1O2, and it was further applied in a biological system to trace the endogenous 1O2 in Hela cells.
Experimental Study of Transmission Characteristics of a Disk Drive's Vibration Characteristics of a Disk Drive's Vibration
Authors: Chiu Min-Chie , Chang Ying-Chun 
Published: December 2014

Presently, there is a trend to design larger capacity hard disks that have a faster revolving speed and a precise mechanism. However, because of external vibrations, these are highly sensitive to data transmission. Therefore, vibration control on hard disks is crucially important. In this paper, a traditional hard disk is placed on a vibration testing device. Data transmission efficiency for the disk will be detected via IOmeter software. Here, the influence of a traditional hard disk's data transmission with respect to external forces (various vibration accelerations), revolving speeds, tilted angles, hardness and thickness of damping material, and material property will be experimentally assessed. Results reveal that a slight tilted angle will result in better data transmission. In addition, the hardness of the hard disk plays an essential role in reducing the vibrational impact on the data transmission. Also, data transmission in the damping material of the shoe cushion will be more efficient than that of a pneumatic cushion. Moreover, the data transmission will decrease when the rotating speed of the disk increases. Consequently, the thickness of the damping material will influence the data transmission even though the hardness is fixed.
Lectotypification of the Linnaean names Lemna arrhiza and L. polyrhiza (Araceae)
Authors: Iamonico Duilio , Iberite Mauro 
Published: December 2014

AbstractThe typification of the Linnaean names Lemna arrhiza and L. polyrhiza (Araceae) is discussed. Two illustrations from Micheli’s work Nova Plantarum Genera are designated as lectotypes for these two names.
Lectotypification of two names in Limoniastrum (Plumbaginaceae)
Authors: Ferrer-Gallego P. Pablo , Iamonico Duilio , Iberite Mauro , Laguna Emilio , Crespo Manuel B. 
Published: December 2014

AbstractThe halophytic shrub genus Limoniastrum has recently been recircumscribed to include only two Mediterranean‐Saharan species, Limoniastrum monopetalum (L.) Boiss. (≡ Statice monopetala L.) and L. guyonianum Boiss. Protologues of both species are briefly discussed and lectotypes are designated using material at BM (Herb. Clifford) and G (Herb. Boissier).
Lectotypification of Linnaean names in the genusScabiosa(Dipsacaceae)
Authors: Ferrer-Gallego P. Pablo 
Published: December 2014

AbstractThe lectotypification of four Linnaean names in the genus Scabiosa (Dipsacaceae):S. alpina(≡Cephalaria alpina),S. arvensis(≡Knautia arvensis),S. leucantha(≡Cephalaria leucantha) andS. succisa(≡Succisa pratensis) is discussed. The designation of the nomenclatural type is based on the consultation of Linnaeus’s original material and the literature cited in the respective protologues. The names are lectotypified using specimens from Linnaeus, Burser and Clifford herbaria.
Vente d’une ânesse par ses copropriétaires
Authors: Gerardin François 
Published: December 2014

AbstractThe papyrus P.Alex. Inv. 536 is here fully published for the first time. It contains the subscriptions for the sale of a female donkey. The buyer, Prosostilla, is known through the archive of Marcus Lucretius Diogenes (P.Diog. 44), thus dating this Fayyum document to the first part of the 3
Reflections on macroeconometric modeling
Authors: Fair Ray C. 
Published: December 2014

AbstractI have been doing research in macroeconomics since the late 1960s, almost 50 years. In this paper I pause and take stock. The paper is part personal reflections on macroeconometric modeling, part a road map of the techniques of macroeconometric modeling, and part comments on what I think I have learned about how the macroeconomy works from my research in this area. Section 1 contrasts the methodology of the Cowles Commission approach with that of DSGE modeling. Section 2 presents the general model that I am using; Section 3 discusses theory; and Section 4 discusses estimation and solution. Section 5 then discusses various results from the estimation; Section 6 discusses various properties of the model; and Section 7 uses the model to analyze various economic events. Wealth effects play a large role in the analysis of past events.
The Reception of the Grimms in Nineteenth- Century France
Authors: Duggan Anne E. 
Published: December 2014

AbstractThis study proposes to fill a gap in Grimm and folklore studies by staking out the landscape of the reception of the Brothers Grimm in nineteenthcentury France. While E. T. A. Hoffmann’s tales received high literary acclaim, those by the Grimms seemed to make little impact on French literature of the period. However, among the French scholarly community, the Grimms were celebrated for their erudition, their integrity, and served as models for many scholars, from the historian Jules Michelet, who corresponded with Jacob Grimm in 1829, to the folklorist Emmanuel Cosquin, whose Contes populaires lorrains (1876) were inspired by the Grimms’ Kinder- und Hausmärchen. Through an analysis of prefaces to French tale collections and to translations of Grimm tales, this essay looks at the impact the reception of the Grimms had on French conceptions of regionalist folklore and on the classical French fairy-tale tradition.
Erfolgsmessung von Enterprise Social Software: Wer? Was? Wie?
Authors: Herzog Christian , Richter Alexander , Steinhüser Melanie , Hoppe Uwe , Koch Michael 
Published: December 2014

ZusammfassungWährend Enterprise Social Software (ESS) zunehmend zum Einsatz kommt, stellt die Evaluierung ihres Nutzens immer noch eine Herausforderung für die meisten Unternehmen dar. Um ein besseres Verständnis für existierende Probleme zu entwickeln und Lösungsansätze zu finden, werden im vorliegenden Beitrag Barrieren der ESS-Erfolgsmessung auf Basis von 26 Experten-Interviews untersucht. Es werden 16 Barrieren identifiziert und in die Kategorien (1) Ressourcen und Verantwortlichkeit, (2) Ziele und Zieldefinition sowie (3) Vorgehen und Datenmaterial eingeordnet. Dabei zeigt sich, dass im Kontext von ESS insbesondere fehlende oder ungenaue Ziele die Erfolgsmessung erschweren und, dass der Erhebung von Nutzungsdaten eine höhere Bedeutung zukommt. Die anschließende Diskussion soll helfen, Potenziale zur Überwindung der Barrieren zu erkennen.
Collaborative elaboration of early innovation ideas
Authors: Kipp Philipp , Bittner Eva Alice Christiane , Bretschneider Ulrich , Leimeister Jan Marco 
Published: December 2014

SummaryWeb-based innovation platforms (WBIP) are common tools for the integration of customers and other external stakeholders into the product and service innovation processes of companies. WBIP of many large companies are very successful in generating many ideas. This leads to WBIP operators drowning in lots of possibly creative and high potential ideas, which are difficult to screen. Therefore, this paper suggests a collaboration process allowing customers to participate collaboratively in the elaboration of self-selected ideas. The collaboration process has been developed following the collaboration process design approach and was designed to be implemented on WBIP.
Gestaltung von Mitfahrsystemen für ältere Erwachsene / Designing ridesharing interaction for older adults
Authors: Meurer Johanna , Stein Martin , Wulf Volker , Rohde Markus 
Published: December 2014

ZusammenfassungDie Gestaltung alternativer Mobilitätsformen für ältere Menschen ist aus wirtschaftlichen, ökologischen und sozialen Gründen eine drängende gesellschaftliche Frage. Mitfahrsysteme, unterstützt durch mobile Anwendungen, können eine vielversprechende Ergänzung zum ÖPNV und Individualverkehr bieten. Allerdings mangelt es derzeit noch an Erfahrung inwiefern Mitfahrkonzepte und -systeme die spezifischen Bedarfe der älteren Bevölkerung berücksichtigen. Um zur Klärung dieser Frage einen Beitrag zu leisten, wurde eine ethnographisch- orientierte Interviewstudie zur Untersuchung der Mitfahrpraktiken von Senioren durchgeführt. Die Studie zeigt Potentiale und Herausforderungen bei alltäglichen Mitfahrten auf und identifiziert Kooperationsstrategien, die anschließend zu Gestaltungsideen für Mitfahrsysteme älterer Nutzer weiter entwickelt werden.