bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: 3,5,5‐Trisubstituted Hydantoins from Activated (Benzyloxycarbonylamino)malonic Acids.
Authors: Hroch Lukas , Hruskova Marie , Schmitz Janina , Schnakenburg Gregor , Guetschow Michael 
Published: August 2012

AbstractTrisubstituted hydantoins (VI) are obtained in low yields from malonic acid derivative (IV) via activation with oxalyl dichloride and subsequent treatment with aromatic amines.
ChemInform Abstract: Oxazole Synthesis from Isocyanides.
Authors: El Kaim Laurent , Grimaud Laurence , Patil Pravin 
Published: August 2012

AbstractTrisubstituted oxazole derivatives of type (IV) can be prepared starting from isocyanides via a one‐pot bromination—cyclization sequence followed by Suzuki cross‐coupling of the resulting bromooxazoles with arylboronic acids.
ChemInform Abstract: Gold(I)‐Catalyzed Intramolecular Hydroamination and Ring‐Opening of Sulfonamide‐Substituted 2‐(Arylmethylene)cyclopropylcarbinols.
Authors: Zhang Di‐Han , Du Kang , Shi Min 
Published: August 2012

AbstractThe novel and highly regioselective title reaction is developed.
ChemInform Abstract: Solvent‐Free One‐Pot 1,3‐Dipolar Cycloaddition Reactions of Dihydropyran Derived Nitrone (III).
Authors: Chakraborty Bhaskar , Sharma Prawin Kumar , Rai Neelam , Sharma Chiran Devi 
Published: August 2012

AbstractMicrowave‐induced 1,3‐dipolar cycloaddition reactions of nitrone (III) with activated alkenes such as (IV) and (VIII) provides access to new isoxazolidine derivatives.
ChemInform Abstract: Synthesis and Evaluation of N‐Phenyl‐(2‐aminothiazol‐4‐yl)acetamides with Phenoxypropanolamine Moiety as Selective β3‐Adrenergic Receptor Agonists.
Authors: Maruyama Tatsuya , Onda Kenichi , Suzuki Takayuki , Hayakawa Masahiko , Takahashi Takumi , Matsui Tetsuo , Takasu Toshiyuki , Nagase Itsuro , Ohta Mitsuaki 
Published: August 2012

AbstractCompounds (Ia)—(Ic) are found to be potent β3‐adrenergic receptor agonists with functional selectivity over the β1‐ and β2‐adrenergic receptors.
ChemInform Abstract: New 1,3‐Dipolar Cycloaddition/Dehydrogenation of Azomethine Ylides and Azodicarboxylates: Direct and Effective Construction of Unsaturated 1,2,4‐Triazolines.
Authors: Xu Xiao‐Ying , et al. et al. 
Published: August 2012

AbstractA general and operationally simple method is developed for the synthesis of a broad spectrum of biologically interesting triazole units.
ChemInform Abstract: Design and Synthesis of New 4‐Pyrazolin‐3‐yl‐1,2,3‐triazoles and 1,2,3‐Triazol‐4‐yl‐pyrazolin‐1‐ylthiazoles as Potential Antimicrobial Agents.
Authors: Abdel‐Wahab Bakr F. , Abdel‐Latif Ehab , Mohamed Hanan A. , Awad Ghada E. A. 
Published: August 2012

AbstractSixteen novel compounds, based on triazole‐linked pyrazolines, are synthesized by routine and facile multistep reactions.
ChemInform Abstract: Broensted Acid Catalyzed Cycloisomerizations of 5,2‐Enyne‐1‐ones: Highly Regioselective Synthesis of 2,3‐Dihydro‐4H‐pyran‐4‐ones.
Authors: Yang Fang , Ji Ke‐Gong , Zhao Shu‐Chun , Ali Shaukat , Ye Yu‐Ying , Liu Xue‐Yuan , Liang Yong‐Min 
Published: August 2012

AbstractThe significantly cheaper Broensted acid TosOH is used instead of a gold complex to activate both the carbonyl and alkene moieties in a cascade manner.
ChemInform Abstract: Chemistry of Phosphorus Ylides. Part 32. Synthesis of Phosphoranylidene‐pyrano‐ and ‐cyclobutyl‐xanthenones with Potential Antitumor Activity.
Authors: Soliman Fouad M. , Said Medhat M. , Youns Mahmoud , Darwish Shaban A. 
Published: August 2012

AbstractThe reactions of phosphacumulenes (II) and (VIII) with several xanthenones and anthrone is studied and the mechanism of the reaction is discussed.
ChemInform Abstract: Stereoselective Synthesis of 3‐Substituted and 3,4‐Disubstituted Piperidine and Piperidin‐2‐one Derivatives.
Authors: Klegraf Ellen , Kunz Horst 
Published: August 2012

AbstractThe reaction of various electrophiles with N‐galactosylpyridinone derivatives proceeds with moderate to high diastereoselectivity to afford the target compounds.
ChemInform Abstract: Ru‐Catalyzed β‐Selective and Enantioselective Addition of Amines to Styrenes Initiated by Direct Arene‐Exchange.
Authors: Otsuka Maiko , Yokoyama Hiroya , Endo Kohei , Shibata Takanori 
Published: August 2012

AbstractThe first example of η6‐arene ruthenium complexes as chiral templates in the enantioselective title reaction is described.
ChemInform Abstract: Regioselective Synthesis of Two Types of Highly Substituted 2‐Pyridones Through Similar Multicomponent Reactions.
Authors: Pathak Sudipta , Kundu Ashis , Pramanik Animesh 
Published: August 2012

AbstractThe reaction in the presence of primary amines yields aminopyridones, whereas with diamines (VI) or (IX) hydroxypyridones are formed.
ChemInform Abstract: Synthesis and in vitro Antiplasmodial Activities of Fluoroquinolone Analogues.
Authors: Dixit Sandeep K. , Mishra Nidhi , Sharma Manish , Singh Shailja , Agarwal Alka , Awasthi Satish K. , Bhasin V. K. 
Published: August 2012

AbstractQuinolone derivative (I), obtained by a reported procedure, is alkylated at position 1 with normal and branched chain alkyl groups as well as some polar groups.
ChemInform Abstract: Synthesis of a Novel Class of Some Biquinoline Pyridine Hybrids via One‐Pot, Three‐Component Reaction and Their Antimicrobial Activity.
Authors: Shah Nimesh M. , Patel Manish P. , Patel Ranjan G. 
Published: August 2012

AbstractTitle compounds (IV) (12 examples) are synthesized and evaluated for their antibacterial activity against Gram‐positive and Gram‐negative bacteria, antifungal and antitubercular activities.
ChemInform Abstract: Catalytic Asymmetric α‐Acylation of Tertiary Amines Mediated by a Dual Catalysis Mode: N‐Heterocyclic Carbene and Photoredox Catalysis.
Authors: DiRocco Daniel A. , Rovis Tomislav 
Published: August 2012

AbstractUnder optimized conditions using RuCl2(bipy)3 as the photocatalyst, MDNB as weak organic oxidant, chiral carbene catalyst TBT, and blue light irradiation, tetrahydroisoquinolines are acylated at the α‐position with aliphatic aldehydes to give the products in a highly enantioselective manner (up to 92% e.e.).
ChemInform Abstract: Palladium(II)‐Catalyzed Intramolecular Diamination of Alkynes under Aerobic Oxidative Conditions: Catalytic Turnover of an Iodide Ion.
Authors: Yao Bo , Wang Qian , Zhu Jieping 
Published: August 2012

AbstractTetracyclic indolo[3,2‐c]isoquinolinones are synthesized under mild conditions.
ChemInform Abstract: Microwave‐Assisted Metal‐Free Synthesis of 2,8‐Diaryl‐6‐aminoimidazo[1,2‐a]pyridine via Amine‐Triggered Benzannulation.
Authors: Nagaraj Muthupandi , Boominathan Muthusamy , Muthusubramanian Shanmugam , Bhuvanesh Nattamai 
Published: August 2012

AbstractA convenient procedure allows the aminobenzannulation of imidazole derivatives (I) with dialkylamines to afford the title compounds (III).
ChemInform Abstract: Multipotent MAO and Cholinesterase Inhibitors for the Treatment of Alzheimer′s Disease: Synthesis, Pharmacological Analysis and Molecular Modeling of Heterocyclic Substituted Alkyl and Cycloalkyl Propargyl Amine.
Authors: Marco‐Contelles Jose , et al. et al. 
Published: August 2012

AbstractA Friedlaender‐type reaction between aminopyridinecarbonitriles (I) and propynylpiperidinone (II) affords the new heterocycles (III) in very good yields.
ChemInform Abstract: New Photochromic 1,1,3‐Trimethylspiro[benzo[e]indoline‐2,3′‐[3H]‐pyrano [3,2‐f]quinoline].
Authors: Aldoshin S. M. , Tkachev V. V. , Khalanskii K. N. , Lukyanov B. S. , Minkin V. I. , Utenyshev A. N. , Alekseenko Yu. S. , Bezuglyi S. O. 
Published: August 2012

AbstractUpon UV irradiation, compound (III) undergoes C—O bond cleavage followed by cis—trans isomerization to form a colored metastable isomer.
ChemInform Abstract: Aqua‐Mediated Indium(III) Chloride Catalyzed Synthesis of Fused Pyrimidines and Pyrazoles.
Authors: Khurana Jitender M. , Chaudhary Ankita , Nand Bhaskara , Lumb Anshika 
Published: August 2012

AbstractThe use of InCl3 in water for three‐component condensations is demonstrated.
ChemInform Abstract: A General Regioselective Synthesis of 2,4‐Diarylpyrimidines from 2‐Thiouracil Through Two Orthogonal Cross‐Coupling Reactions.
Authors: Cernova Miroslava , Pohl Radek , Klepetarova Blanka , Hocek Michal 
Published: August 2012

AbstractAn efficient two‐step procedure allows the synthesis of 2,4‐diarylpyrimidines via phosphonium‐mediated Suzuki coupling and Liebeskind—Srogl reaction.
ChemInform Abstract: Design of [(2‐Pyrimidinylthio)acetyl]benzenesulfonamides as Inhibitors of Human Carbonic Anhydrase.
Authors: Capkauskaite Edita , Zubriene Asta , Baranauskiene Lina , Tamulaitiene Giedre , Manakova Elena , Kairys Visvaldas , Grazulis Saulius , Tumkevicius Sigitas , Matulis Daumantas 
Published: August 2012

AbstractS‐Alkylation of pyrimidine derivatives (I) with ω‐bromoacetylbenzenesulfonamides (II) and (IV) affords the title compounds (III) and (V), respectively.
ChemInform Abstract: Regioselective Synthesis of Trialkylpyrazines via Nickel‐Catalyzed Negishi Cross‐Coupling of Pyrazine Triflate.
Authors: Pitchaiah Arigala , Hwang In Taek , Hwang Jin‐Soo , Kim Hyungrok , Lee Kee‐In 
Published: August 2012

AbstractThe ‐O‐Tf substituent can be replaced by treatment with organometal reagents where the use of zinc bromides is found to be the most efficient one.
ChemInform Abstract: Synthesis and Antitumor Activities of Novel Oxazinyl Isoflavonoids.
Authors: Wang Dun , Hou Like , Wu Lirong , Yu Xin 
Published: August 2012

AbstractA novel series of isoflavonoid compounds containing protected phenolic groups with oxazinyl moieties is prepared and evaluated for in vitro antitumor activities against SKOV‐3, DU‐145, and HL‐60 human cancer cell lines.
ChemInform Abstract: Structure and Properties of 3,6′‐Dimethyl‐2,3‐dihydrospiro[naphtho[1,3]oxazine‐2,2′‐ [2H]‐chromen]‐4‐ones.
Authors: Aldoshin S. M. , Mukhanov E. L. , Lukyanov B. S. , Bezuglyi S. O. , Lukyanova M. B. , Utenyshev A. N. , Tkachev V. V. , Minkin V. I. 
Published: August 2012

AbstractTitle compounds (III) are synthesized and evaluated for their photochromic properties.
ChemInform Abstract: Synthesis of Coumarin‐ and Quinolone‐Annulated Benzazocinone Frameworks by a Palladium‐Catalyzed Intramolecular Heck Reaction.
Authors: Majumdar K. C. , Samanta Srikanta , Ghosh Tapas 
Published: August 2012

AbstractThe efficient process is extended to the structurally related naphthalene derivative (III).
ChemInform Abstract: Synthesis and Biological Evaluation of Novel Bifendate Derivatives Bearing 6, 7‐Dihydro‐dibenzo[c,e]azepine Scaffold as Potent P‐Glycoprotein Inhibitors.
Authors: Gu Xiaoke , Ren Zhiguang , Tang Xiaobo , Peng Hui , Zhao Qing , Lai Yisheng , Peng Sixun , Zhang Yihua 
Published: August 2012

AbstractCombining N‐substituted tertiary amines with the six‐alkoxyl biphenyl structure leads to compounds (III) each with a dihydrodibenzoazepine ring to improve the P‐gp inhibitory effect and affinity of the title scaffold with P‐gp.
ChemInform Abstract: Sc(OTf)3/TsOH: A Highly Efficient Catalytic System for the Synthesis of 2,6‐Dioxabicyclo[3.2.1]octane Derivatives.
Authors: Reddy B. V. Subba , Narasimhulu G. , Reddy Y. Vikram , Chakravarthy P. P. , Yadav J. S. , Sridhar B. 
Published: August 2012

AbstractThe selective formation of the bicyclic systems is achieved by an intramolecular Prins cyclization of allylic diol (I) and aldehydes (II) under optimized conditions.
ChemInform Abstract: Substituted Potassium Internal Vinyltrifluoroborates: Preparation and Use in Suzuki—Miyaura Cross‐Coupling Reactions.
Authors: Math Shivanand K. , Mokri Homayoun H. , LaMunyon James B. , Cefalo Dustin R. , Testa Charles A. 
Published: August 2012

AbstractAir‐stable crystalline vinyltrifluoroborates (II) and (IV) bearing either ether or amine functionalities are prepared following the sequence A)‐C).
ChemInform Abstract: Sandmeyer‐Type Reaction to Pinacol Arylboronates in Water Phase: A Green Borylation Process.
Authors: Zhang Jie , Wang Xiaolong , Yu Haitao , Ye Jiahai 
Published: August 2012

AbstractCopper‐catalyzed cross‐coupling of aryl diazonium salts with diboron (II) proceeds under mild conditions and allows the direct synthesis of arylboronates bearing halogen and acidic substituents.
ChemInform Abstract: Practical and Efficient Applications of Novel Dioxaborolanes and Dioxaborinanes in the Synthesis of Corresponding Boronates and Their Use in the Palladium‐Catalyzed Cross‐Coupling Reactions.
Authors: Myslinska Malgorzata , Heise Glenn L. , Walsh Dana J. 
Published: August 2012

AbstractDerivatives of glycol borates react efficiently with Grignard reagents or lithiated arenes to yield the corresponding cyclic boronates.
ChemInform Abstract: Synthesis of Monoarylated Diynes by Monoprotection/Cross‐Coupling/Deprotection Approach.
Authors: Kral Karolin , Hapke Marko 
Published: August 2012

AbstractProtection of symmetrical diynes (I) with TmsCl results in formation of inseparable mixtures of mono‐ and di‐protected products (III) and (IV) with the former as the major component.
ChemInform Abstract: Palladium‐Catalyzed Direct Phosphonation of Azoles with Dialkyl Phosphites.
Authors: Hou Chaodong , Ren Yunlai , Lang Rui , Hu Xiaoxue , Xia Chungu , Li Fuwei 
Published: August 2012

AbstractAn atom‐efficient direct Pd‐catalyzed phosphonation of benzothiazoles (I) and benzoxazoles (IV) with dialkyl phosphites is achieved in the absence of acid or base additives.
ChemInform Abstract: The Conversion of Oridonin to Spirolactone‐Type or Enmein‐Type Diterpenoid: Synthesis and Biological Evaluation of ent‐6,7‐seco‐Oridonin Derivatives as Novel Potential Anticancer Agents.
Authors: Wang Lei , Li Dahong , Xu Shengtao , Cai Hao , Yao Hequan , Zhang Yihua , Jiang Jieyun , Xu Jinyi 
Published: August 2012

AbstractThe conversion of oridonin (I) to spirolactone‐type (III) or enmein‐type diterpenoid (VI) and (VII) is conducted as well as spirolactone‐type diterpenoid to enmein‐type diterpenoid.
ChemInform Abstract: Studies on the Constituents of Cimicifuga foetida Collected in Guizhou Province and Their Cytotoxic Activities.
Authors: Lu Lu , Chen Jian‐Chao , Li Yan , Qing Chen , Wang Yuan‐Yuan , Nian Yin , Qiu Ming‐Hua 
Published: August 2012

AbstractTwo new triterpenoids, 24‐epi‐cimigenol‐3‐one (I), foetinoside (II) and a new chromone glycoside (III) are isolated together with 18 known compounds.
ChemInform Abstract: Synthesis and Biological Activity of 23‐Ethylidene‐26‐hydroxy‐22‐oxocholestane Derivatives from Spirostanic Sapogenins.
Authors: Perez‐Diaz Jose Oscar H. , Rarova Lucie , Munoz Ocampo J. Paul , Magana‐Vergara Nancy E. , Farfan Norberto , Strnad Miroslav , Santillan Rosa 
Published: August 2012

AbstractThree new cholestane frameworks of type (II) are obtained by reductive cleavage of the F‐ring of oxoepoxycholestane derivatives (I) without detectable competing 1,2‐reduction of the α,β‐unsaturated carbonyl group at C‐22.
ChemInform Abstract: Synthesis and SAR Studies of Phenanthroindolizidine and Phenanthroquinolizidine Alkaloids as Potent Antitumor Agents.
Authors: Wang Qingmin , et al. et al. 
Published: August 2012

AbstractThe phenanthroindolizidine alkaloids (X) are prepared by using a similar route that is used for the synthesis of racemic tylophorine.
ChemInform Abstract: Indole Alkaloids from Alocasia macrorrhiza.
Authors: Zhu Ling‐hua , Chen Cheng , Wang Hui , Ye Wen‐cai , Zhou Guang‐xiong 
Published: August 2012

AbstractAlocasin A (I), B (IIa), C (IIb), D (IIc) and alocasin E (III) are isolated together with known compounds hyrtiosin B and hyrtiosulawesin.
ChemInform Abstract: An Efficient Synthetic Approach to 6,5′‐(S)‐ and 6,5′‐(R)‐Cyclouridine.
Authors: Theile Christopher S. , McLaughlin Larry W. 
Published: August 2012

AbstractCyclouridines (XII) and (XIII) are obtained using the radical cyclization of iodide (VII) and subsequent dehydrohalogenation as the key steps.
ChemInform Abstract: Ianthellamide A, a Selective Kynurenine‐3‐hydroxylase Inhibitor from the Australian Marine Sponge Ianthella quadrangulata.
Authors: Feng Yunjiang , Bowden Bruce F. , Kapoor Vimal 
Published: August 2012

AbstractThe novel octopamine derivative ianthellamide A (I) selectively inhibits the activity of kynurenine 3‐hydroxylase and also significantly increases the level of endogenous kynurenic acid in rat brain.
ChemInform Abstract: Discovery of Cariprazine (RGH‐188): A Novel Antipsychotic Acting on Dopamine D3/D2 Receptors.
Authors: Agai‐Csongor Eva , et al. et al. 
Published: August 2012

AbstractMedicinal chemistry optimization of an impurity isolated during the scale‐up synthesis of a pyridylsulfonamide‐type compound as a high‐affinity dopamine D3/D2 receptor ligand leads to a series of new piperazine derivatives having affinity to both dopamine D3and D2 receptors.
ChemInform Abstract: Broensted Acid Activation Strategy in Transition‐Metal Catalyzed Asymmetric Hydrogenation of N‐Unprotected Imines, Enamines, and N‐Heteroaromatic Compounds
Authors: Yu Zhengkun , Jin Weiwei , Jiang Quanbin 
Published: August 2012

AbstractReview: 128 refs.
Oxidative Coupling of Methane: Optimal Operating Policies for a Membrane Reactor Network
Authors: Lenhart Eva , Esche Erik , Arellano‐Garcia Harvey , Biegler Lorenz T. 
Published: August 2012

AbstractThe oxidative coupling of methane (OCM), in which methane is turned into ethylene and ethane, presents an opportunity for using natural gas to produce desired C2 hydrocarbons. The main challenge for the successful implementation of the process is the reduction of undesired by‐products, such as CO2. This contribution deals with the optimization of a membrane reactor network for the OCM process with the goal of maximizing yield while maintaining simultaneously a high selectivity in C2 products. The network consists of a plug flow/fixed‐bed reactor, a conventional packed‐bed membrane reactor and a so‐called proposed packed‐bed membrane reactor.
Resource‐Efficient Alkane Selective Oxidation on New Crystalline Solids: Searching for Novel Catalyst Materials
Authors: Glaum Robert , Welker‐Nieuwoudt Cathrin , Dobner Cornelia‐Katharina , Eichelbaum Maik , Gruchow Falk , Heine Christian , Karpov Andrey , Kniep Rüdiger , Rosowski Frank , Schlögl Robert , Schunk Stephan Andreas , Titlbach Sven , Trunschke Annette 
Published: August 2012

AbstractA total of 29 hitherto unknown vanadyl(IV)‐, vanadyl(V)‐, and vanadate(V) phosphates were synthesized, structurally characterized, and tested in terms of their behavior as catalysts in the selective oxidation of n‐butane to maleic anhydride. The new materials did not surpass the performance of commercially used (VIVO)2P2O7‐based catalysts, but a silver vanadium phosphate of approximate composition Ag2VIV,VP1.6O7+δ (0 ≤ δ ≤ 0.5), supposedly having a vanadyl(IV, V) phosphate pyrophosphate layer structure, shows promising activity and selectivity with potential for further improvements. With the aim to study the charge carrier dynamics a new method for in situ non‐contact measurement of the electric conductivity of catalysts was developed. The analysis of conductivity changes in response to the chemical potential of oxygen in the gas phase offers valuable clues to understand structure‐reactivity relationships in selective oxidation catalysis.
Conformational Control of the Electronic Properties of an α‐β Terthiophene: Lessons from a Precursor Towards Dendritic Hyperbranched Oligo‐ and Poly‐Thiophenes
Authors: González Cano Rafael C. , Herrera Helena , Segura José L. , López Navarrete Juan T. , Ruiz Delgado M. Carmen , Casado Juan 
Published: August 2012

AbstractHerein we investigate the conformational and electronic properties of the 2,2′;3′,2“‐terthiophene (B3T) unit as the building block of thiophene dendrimeric materials. By means of DFT ground electronic state dihedral energy profiles, we get insight in the flexibility of B3 T as the prominent feature promoting the 3D arrangement. The presence of diverse conformers is explored by Raman and 1H NMR spectroscopies. A theoretical estimation of the Raman and 1H NMR spectra over the most energetically accessible conformers is found to be crucial for the appropriate assignment of the major conformer population derived from the experimental spectra. We show that energy barriers for the interconversion of conformers also play a role. Finally, the impact on the optical spectra (absorption and emission) of the α–α and α–β connections is studied and addressed by scanning the properties of the relevant low‐lying excited states. These studies highlight the relevance of the architecture of the basic molecular unit to understand charge and exciton behavior in organic semiconductors, particularly for those useful in photovoltaics.
Synthesis of Substituted Coumarins and 2‐Quinolinones by Cycloisomerisation of (Hydroxy/aminophenyl)propargyl Alcohols
Authors: Sridhar Reddy Maddi , Thirupathi Nuligonda , Babu Madala Hari 
Published: August 2012

AbstractA new cycloisomerization strategy for the synthesis of coumarins and quinolinones is described. The addition of ethoxyacetylide to 2‐hydroxyacetophenones directly resulted in 4‐substituted coumarins by 6‐endo‐dig cycloisomerisation of the intermediate 3‐ethoxy‐1‐(2‐hydroxyphenyl)‐2‐propyn‐1‐ols. Under similar conditions, 2‐aminoacetophenone produced 2‐ethoxyquinoline, a masked quinolinone, which was converted into the quinolinone by acid treatment. N‐Protected intermediate 8 was isolated and converted into the quinolinone [with In(OTf)3 or H2SO4] or the 3‐iodo‐2‐quinolinone (with I2 and H+).
Moving grid method for numerical simulation of stratified flows
Authors: Koltakov S. , Fringer O. B. 
Published: August 2012

SUMMARYWe develop a second‐order accurate Navier–Stokes solver based on r‐adaptivity of the underlying numerical discretization. The motion of the mesh is based on the fluid velocity field; however, certain adjustments to the Lagrangian velocities are introduced to maintain quality of the mesh. The adjustments are based on the variational approach of energy minimization to redistribute grid points closer to the areas of rapid solution variation. To quantify the numerical diffusion inherent to each method, we monitor changes in the background potential energy, computation of which is based on the density field. We demonstrate on a standing interfacial gravity wave simulation how using our method of grid evolution decreases the rate of increase of the background potential energy compared with using the same advection scheme on the stationary grid. To further highlight the benefit of the proposed moving grid method, we apply it to the nonhydrostatic lock‐exchange flow where the evolution of the interface is more complex than in the standing wave test case. Naive grid evolution based on the fluid velocities in the lock‐exchange flow leads to grid tangling as Kelvin–Helmholtz billows develop at the interface. This is remedied by grid refinement using the variational approach. Copyright © 2012 John Wiley & Sons, Ltd.