bluuebunny/crossref_metadata_2025_split huggingface dataset:
Long-Term Efficacy and Safety of Biodegradable-Polymer Biolimus-Eluting Stents
Authors: Kaiser Christoph , Galatius Soeren , Jeger Raban , Gilgen Nicole , Jensen Jan Skov , Naber Christoph , Alber Hannes , Wanitschek Maria , Eberli Franz , Kurz David J. , Pedrazzini Giovanni , Moccetti Tiziano , Rickli Hans , Weilenmann Daniel , Vuillomenet André , Steiner Martin , Felten Stefanie Von , Vogt Deborah R. , Hansen Kim Wadt , Rickenbacher Peter , Conen David , Müller Christian , Buser Peter , Hoffmann Andreas , Pfisterer Matthias 
Published: November 2014

Background—
Biodegradable-polymer drug-eluting stents (BP-DES) were developed to be as effective as second-generation durable-polymer drug-eluting stents (DP-DES) and as safe >1 year as bare-metal stents (BMS). Thus, very late stent thrombosis (VLST) attributable to durable polymers should no longer appear.

Methods and Results—

To address these early and late aspects, 2291 patients presenting with acute or stable coronary disease needing stents ≥3.0 mm in diameter between April 2010 and May 2012 were randomly assigned to biolimus-A9–eluting BP-DES, second-generation everolimus-eluting DP-DES, or thin-strut silicon-carbide–coated BMS in 8 European centers. All patients were treated with aspirin and risk-adjusted doses of prasugrel. The primary end point was combined cardiac death, myocardial infarction, and clinically indicated target-vessel revascularization within 2 years. The combined secondary safety end point was a composite of VLST, myocardial infarction, and cardiac death. The cumulative incidence of the primary end point was 7.6% with BP-DES, 6.8% with DP-DES, and 12.7% with BMS. By intention-to-treat BP-DES were noninferior (predefined margin, 3.80%) compared with DP-DES (absolute risk difference, 0.78%; −1.93% to 3.50%;
P
for noninferiority 0.042; per protocol
P
=0.09) and superior to BMS (absolute risk difference, −5.16; −8.32 to −2.01;
P
=0.0011). The 3 stent groups did not differ in the combined safety end point, with no decrease in events >1 year, particularly VLST with BP-DES.

Conclusions—
In large vessel stenting, BP-DES appeared barely noninferior compared with DP-DES and more effective than thin-strut BMS, but without evidence for better safety nor lower VLST rates >1 year. Findings challenge the concept that durable polymers are key in VLST formation.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01166685.
The complete mitochondrial genome of Aphelenchoides besseyi (Nematoda: Aphelenchoididae), the first sequenced representative of the subfamily Aphelenchoidinae
Authors: Sun Longhua , Zhuo Kan , Wang Honghong , Song Handa , Chi Wenwei , Zhang Lian-Hui , Liao Jinling 
Published: November 2014

The complete mitochondrial genome (mitogenome) ofAphelenchoides besseyiis 16 216 bp in size and has the typical organisation of nematode mitogenomes of Chromadorea, including 12 protein-coding genes (PCGs), two rRNA genes, 22 tRNA genes and the AT-rich non-coding region. The nucleotide composition of the mitogenome ofA. besseyiis AT-biased (80.0%) and the AT skew is −0.289. The most common start codon forA. besseyiis ATT. Thenad3andnad4Lgenes have an incomplete stop codon consisting of just a T and the other PCGs stop with the full stop codons. All the tRNA genes display a non-typical cloverleaf structure of mitochondrial tRNA. The AT-rich non-coding region contains ten tandem repeat units with four different regions. Phylogenetic analysis based on concatenated amino acid sequences of 12 protein-coding genes showed that three Tylenchomorpha species, includingA. besseyi,Bursaphelenchus mucronatusandB. xylophilusfrom the superfamily Aphelenchoidea, are placed within a well-supported monophyletic clade, but far from the other six Tylenchomorpha speciesMeloidogyne chitwoodi,M. graminicola,M. incognita,Pratylenchus vulnus,Heterodera glycinesandRadopholus similisof Tylenchoidea. This phylogeny suggests thatAphelenchoideshas a close relative relationship withBursaphelenchusand that the Tylenchomorpha is not monophyletic.
Probabilistic Multiple Linear Regression Modeling for Tropical Cyclone Intensity
Authors: Lee Chia-Ying , Tippett Michael K. , Camargo Suzana J. , Sobel Adam H. 
Published: November 2014

Abstract
The authors describe the development and verification of a statistical model relating tropical cyclone (TC) intensity to the local large-scale environment. A multiple linear regression framework is used to estimate the expected intensity of a tropical cyclone given the environmental and storm conditions. The uncertainty of the estimate is constructed from the empirical distribution of model errors. NCEP–NCAR reanalysis fields and historical hurricane data from 1981 to 1999 are used for model development, and data from 2000 to 2012 are used to evaluate model performance. Seven predictors are selected: initial storm intensity, the change of storm intensity over the past 12 h, the storm translation speed, the difference between initial storm intensity and its corresponding potential intensity, deep-layer (850–200 hPa) vertical shear, atmospheric stability, and 200-hPa divergence. The system developed here models storm intensity changes in response to changes in the surrounding environment with skill comparable to existing operational forecast tools. Since one application of such a model is to predict changes in TC activity in response to natural or anthropogenic climate change, the authors examine the performance of the model using data that is most readily available from global climate models, that is, monthly averages. It is found that statistical models based on monthly data (as opposed to daily) with only a few essential predictors, for example, the difference between storm intensity and potential intensity, perform nearly as well at short leads as when daily predictors are used.
Molecular dynamics simulations: from structure function relationships to drug discovery
Authors: Nair Pramod C , Miners John O 
Published: November 2014

AbstractMolecular dynamics (MD) simulation is an emerging in silico technique with potential applications in diverse areas of pharmacology. Over the past three decades MD has evolved as an area of importance for understanding the atomic basis of complex phenomena such as molecular recognition, protein folding, and the transport of ions and small molecules across membranes. The application of MD simulations in isolation and in conjunction with experimental approaches have provided an increased understanding of protein structure-function relationships and demonstrated promise in drug discovery.
Myocardial interleukin-6 in the setting of left ventricular mechanical assistance: relation with outcome and C-reactive protein
Authors: Caruso Raffaele , Caselli Chiara , Cozzi Lorena , Campolo Jonica , Viglione Federica , Parolini Marina , Nonini Sandra , Trunfio Salvatore , D’Amico Andrea , Pelosi Gualtiero , Giannessi Daniela , Marraccini Paolo , Frigerio Maria , Parodi Oberdan 
Published: November 2014

AbstractIn left ventricular assist device (LVAD) recipients, plasma levels of interleukin (IL)-6 are associated with Interagency Registry for Mechanically Assisted Circulatory Support (INTERMACS) profiles, reflecting post-operative risk. However, it is not clear how the cardiac level of IL-6, detectable on the tissue samples at the time of implantation, can contribute to predict the post-operative outcome.In 40 LVAD recipients, blood and myocardial samples from LV-apex were collected at the time of implantation to assess plasma and cardiac IL-6 levels. Serum C-reactive protein (CRP) levels were considered as inflammatory variable routinely used in LVAD-based therapy.Cardiac IL-6 levels did not correlate with either plasma IL-6 levels (R=0.296, p=0.063) and tissue IL-6 mRNA expression (R=–0.013, p=0.954). Contrary to what happened for the plasma IL-6 and CRP, no differences were observed in cardiac IL-6 levels with respect to INTERMACS profiles (p=0.090). Furthermore, cardiac IL-6 concentrations, unlike IL-6 and CRP circulating levels, were not correlated with the length of intensive care unit stay and hospitalization.Cardiac IL-6 levels do not contribute to improve risk profile of LVAD recipients in relation to clinical inpatient post-implantation. Instead, plasma IL-6 and serum CRP concentrations are more effective in predicting the severity of the clinical course in the early phase of LVAD therapy.
The Partners HealthCare Settlement and the Future of Health Care Organizations
Authors: Richman Barak D. , Schulman Kevin A. 
Published: November 2014

Abstract
A recent settlement between Massachusetts and Partners HealthCare, along with successful antitrust actions by the Federal Trade Commission, may signal the beginning of the end of two decades of consolidation of health care providers. This consolidation has been associated with higher prices resulting from market power, justifying the antitrust actions. However, the appropriate remedy for the health sector is a unique challenge. The proposed settlement appears to lock into place the legacy of the hospital-based delivery model, rather than orchestrating a pathway to a new care delivery models. Clearly, we need a regulatory framework that will introduce innovative alternatives into the market, not enshrine the current costly paradigm.
Outliers in American juvenile justice: the need for statutory reform in North Carolina and New York
Authors: Tedeschi Frank , Ford Elizabeth 
Published: November 2014

Abstract
There is a well-established and growing body of evidence from research that adolescents who commit crimes differ in many regards from their adult counterparts and are more susceptible to the negative effects of adjudication and incarceration in adult criminal justice systems. The age of criminal court jurisdiction in the United States has varied throughout history; yet, there are only two remaining states, New York and North Carolina, that continue to automatically charge 16 year olds as adults. This review traces the statutory history of juvenile justice in these two states with an emphasis on political and social factors that have contributed to their outlier status related to the age of criminal court jurisdiction. The neurobiological, psychological, and developmental aspects of the adolescent brain and personality, and how those issues relate both to a greater likelihood of rehabilitation in appropriate settings and to greater vulnerability in adult correctional facilities, are also reviewed. The importance of raising the age in New York and North Carolina not only lies in protecting incarcerated youths but also in preventing the associated stigma following release. Mental health practitioners are vital to the process of local and national juvenile justice reform. They can serve as experts on and advocates for appropriate mental health care and as experts on the adverse effects of the adult criminal justice system on adolescents.
Taking a toy gun to school: a consideration of the determinants of adolescent forensic behavior in the aftermath of the Sandy Hook shooting
Authors: Rice Timothy R. , Hoffman Leon 
Published: November 2014

Abstract
Adolescent forensic behavior can have a variety of meanings. A consideration of the range of meanings can inform the practice of the psychiatric forensic evaluation. This case report describes the history of an adolescent in individual treatment for disruptive and self-defeating behaviors who brought a concealed toy gun into his high school in the aftermath of the Sandy Hook shooting. The overdetermined nature of this act, as well as a consideration of its multiple meanings in the context of the young man’s psychology, his educational and family systems, and his relationship with his treatment provider, will be described and developed. The discussion will broaden to consider the parameters of indicated therapeutic programs to address this subset of adolescent forensic behaviors. The role of deficient implicit emotion regulation capacities in adolescents and the corrective measures to target these neurobehavioral deficits will be described. The report concludes with implications for primary prevention of future adolescent forensic behaviors.
Optimal risk allocation for convex risk functionals in general risk domains
Authors: Kiesel Swen , Rüschendorf Ludger 
Published: November 2014

Abstract
In this paper, we formulate the classical optimal risk allocation problem for convex risk functionals defined on products of real Banach spaces as risk domains. This generality includes in particular the classical case of Lp
risks but also allows to describe the influence of dependence in the risk allocation problem. We characterize optimal allocations and complete known existence and uniqueness results from the literature.
We discuss in detail an application to expected risk functionals. This case can be dealt with by the Banach space approach applied to Orlicz hearts associated to the risk functionals.
We give a detailed discussion of the necessary continuity and differentiability properties. Based on ordering results for Orlicz hearts we obtain extensions of the optimal allocation results to different Orlicz hearts as domain of risk functionals and establish a general form of the classical Borch theorem.
In some numerical examples, optimal redistributions are determined for the expected risk case and the precision of the numerical calculation is checked.
Systematic identification of cell size regulators in budding yeast
Authors: Soifer Ilya , Barkai Naama 
Published: November 2014

AbstractCell size is determined by a complex interplay between growth and division, involving multiple cellular pathways. To identify systematically processes affecting size control in G1 in budding yeast, we imaged and analyzed the cell cycle of millions of individual cells representing 591 mutants implicated in size control. Quantitative metric distinguished mutants affecting the mechanism of size control from the majority of mutants that have a perturbed size due to indirect effects modulating cell growth. Overall, we identified 17 negative and dozens positive size control regulators, with the negative regulators forming a small network centered on elements of mitotic exit network. Some elements of the translation machinery affected size control with a notable distinction between the deletions of parts of small and large ribosomal subunit: parts of small ribosomal subunit tended to regulate size control, while parts of the large subunit affected cell growth. Analysis of small cells revealed additional size control mechanism that functions in G2/M, complementing the primary size control in G1. Our study provides new insights about size control mechanisms in budding yeast.
Lectura, infancia y políticas inclusivas en Brasil: reflexiones sobre la experiencia literaria y la diversidad cultural en el arte
Authors: Cardoso Rosane , Leiria Elisandra 
Published: November 2014

En Brasil, desde 2003, data na que entra en vigor a Lei 10.639, establécense directrices para a educación inclusiva, a través da introdución da historia e da literatura africanas, afrobrasileiras e indíxenas na escola. O propósito do governo é combatir unha situación crónica no país: a discriminación étnico-racial cara aos negros e indíxenas. Esta análise traza unha breve panorámica da Literatura Infantil e Xuvenil de temática afrobrasileira, reflexionando sobre a conciliación entre a Lei, a arte literaria e a representación do personaxe negro en textos para nenos. O noso obxectivo é problematizar se as políticas afirmativas poden rebater o racismo e, simultaneamente, valorizar a fruición lectora, outro longo desafío da educación brasileira.DOI http://dx.doi.org/10.15304/elos.1.1719
Comparison of sensor characteristics of three real‐time monitors for organic vapors
Authors: Hori Hajime , Ishimatsu Sumiyo , Fueta Yukiko , Hinoue Mitsuo , Ishidao Toru 
Published: November 2014

Comparison of sensor characteristics of three real‐time monitors for organic vapors: Hajime HORI, et al. Department of Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Japan—ObjectiveSensor characteristics and performance of three real‐time monitors for volatile organic compounds (VOC monitor) equipped with a photo ionization detector (PID), a sensor using the interference enhanced reflection (IER) method and a semiconductor gas sensor were investigated for 52 organic solvent vapors designated as class 1 and class 2 of organic solvents by the Ordinance of Organic Solvent Poisoning Prevention in Japan.MethodsTest vapors were prepared by injecting each liquid solvent into a 50 l Tedlar® bag and perfectly vaporizing it. The vapor concentration was from one‐tenth to twice the administrative control level for all solvents. The vapor concentration was measured with the monitors and a gas chromatograph equipped with a flame ionization detector simultaneously, and the values were compared.ResultsThe monitor with the PID sensor could measure many organic vapors, but it could not detect some vapors with high ionization potential. The IER sensor could also detect many vapors, but a linear response was not obtained for some vapors. A semiconductor sensor could detect methanol that could not be detected by PID and IER sensors.ConclusionsWorking environment measurement of organic vapors by real‐time monitors may be possible, but sensor characteristics and their limitations should be known.
Medically Induced Euthyroid Hypothyroxinemia May Extend Survival in Compassionate Need Cancer Patients: An Observational Study
Authors: Hercbergs Aleck , Johnson Rebecca E. , Ashur-Fabian Osnat , Garfield David H. , Davis Paul J. 
Published: November 2014

Abstract

Background.
Clinical studies have shown that interventional lowering of serum free thyroxine (FT4) may be associated with extended survival in patients with some terminal cancers. The report of success with this approach in glioblastoma multiforme caused involvement of the author (A.H.) in the prospective consultative management of 23 end-stage solid tumor patients in whom hypothyroxinemia was induced to prolong life.

Patients and Methods.
Patients were self-referred or recommended by attending physicians to the author (A.H.) and had advanced cancers of the brain, ovary, lung, pancreas, salivary gland, and breast or had mesothelioma or soft-tissue sarcoma. Hypothyroxinemia was achieved in euthyroid patients by using methimazole, with the addition of 3,3′,5-triiodo-l-thyronine (l-T3) to prevent hypothyroidism and suppress endogenous thyrotropin (TSH). In patients with pre-existent primary hypothyroidism, T3 administration was substituted for T4 replacement. Serum FT4 and TSH concentrations were serially monitored to enable adjustments to drug therapy and prevent clinical hypothyroidism. Survival was measured from the date of hypothyroxinemia induction with T3 or methimazole plus T3. Outcomes were compared with the odds of death based on the Surveillance Epidemiology and End Results and American Joint Committee on Cancer databases and literature reports.

Results.
The survival time of 83% (19 of 23) of patients exceeded the 20% expected 1-year survival for this hypothyroxinemic, end-stage cancer group. The difference between actual and expected survival was significant.

Conclusion.
Although this is an uncontrolled observational experience with frank limitations, compassionate medical induction of hypothyroxinemia should be considered for patients with advanced cancers to whom other avenues of treatment are closed.
The Well-Being of Relatives of Patients with Atrial Fibrillation: A Critical Incident Technique Analysis
Authors: Ekblad Helena , Malm Dan , Fridlund Bengt , Conlon Lisa , Rönning Helén 
Published: November 2014

Background:
The well-being of relatives of patients having chronic heart diseases (CHD) has been found to be negatively affected by the patient’s condition. Studies examining relatives of patients with atrial fibrillation (AF) indicate that their well-being may be affected in a similar manner, but further research is needed.

Aim:
To explore and describe critical incidents in which relatives of patients experience how AF affects their well-being and what actions they take to handle these situations. Design and method: An explorative, descriptive design based on the critical incident technique (CIT) was used. Interviews were conducted with 19 relatives (14 women and five men) of patients hospitalised in southern Sweden due to acute symptoms of the AF.

Results:
The well-being of relatives was found to be affected by their worries (patient-related health), as well as the sacri-ficing of their own needs (self-related health). In handling their own well-being, these relatives adjusted to and supported the patient (practical involvement), along with adjusting their own feelings and responding to the mood of the patients (emotional involvement).

Conclusion:
The well-being of relatives of patients with AF was affected depending on the patients’ well-being. In their attempt to handle their own well-being, the relatives adjusted to and supported the patients. Further research is needed in order to evaluate the effects of support to relatives and patients respectively and together.
Acute–Phase Inflammatory Response in Patients with Pulmonary Tuberculosis
Authors: Radović Milan , Pejčić Tatjana , Stanković Ivana , Ristić Lidija , Rančić Milan , Ćirić Zorica 
Published: November 2014

Summary
The main issue in patients with pulmonary tuberculosis (PTB) represents the impossibility of the host immune response to express bactericidal function and the sterilization of lesions depends exclusively on the specific antimicrobial chemotherapy.
In order to investigate the value of acute-phase inflammatory response markers in patients with newly confirmed extensive PTB, there was designed a clinical study with 80 patients, of whom 40 had active disease (experimental group), while other 40 had inactive sequellar disease without comorbidity (control group).
The examined groups were homogenous with respect to the patient’s general demographic characteristics. In the experimental group, 20.0% of the patients had an initial bacterial infection of the lower respiratory tract, while their average value of acute-phase systemic inflammatory markers was initially, before the antituberculosis treatment, significantly elevated compared to the control group. At the end of the treatment, values of erythrocyte sedimentation rate in the first hour (SE) and serum C-reactive protein (CRP) significantly decreased (SE-p <0.001, CRP-p<0.001), together with the value of the leukocyte count (Le) and serum fibrinogen (Le-p<0.001, fibrinogen-p<0.001). Multivariate linear regression analysis proved a significant correlation between baseline serum fibrinogen level with positive history of contact with active TB patient and initial radiological extent of PTB lung lesions.
The values of the acute-phase inflammatory response markers in active PTB have its clinical significance in the assessment of unfavourable course of disease in extensive disseminated form of PTB as well as in the occurrence of complications associated with low respiratory tract bacterial superinfection.
Changes of mycorrhizal colonization along moist gradient in a vineyard of Eger (Hungary)
Authors: Donkó Ádám , Zanathy Gábor , Èros-Honti Zsolt , Villangó Szabolcs , Bisztray György Dénes 
Published: November 2014

Abstract
The role of mycorrhizal fungi has special importance in the case of low soil moisture because the colonization of vine roots by mycorrhiza increases water and nutrient uptake and thus aids the avoidance of biotic and abiotic stresses of grape. Our aim was to investigate in the Eger wine region the changes of mycorrhizal colonization, water potential, and yield quality and quantity of grape roots at three altitudes, along a changing soil moist gradient. Our results show that the degree of mycorrhizal colonization is higher in drier areas, which supports the water and nutrient uptake of the host plant.