bluuebunny/crossref_metadata_2025_split huggingface dataset:
Polyethyleneimine/Manganese‐Doped ZnS Nanocomposites: A Multifunctional Probe for Two‐Color Imaging and Three‐Dimensional Sensing
Authors: Sang Li‐Jia , Wu Ye‐Yu , Wang He‐Fang 
Published: March 2013

AbstractWe present herein a new single probe, polyethyleneimine (PEI)/MnZnS nanocomposite, for two‐color imaging and three‐dimensional sensing. The PEI/MnZnS nanocomposite possesses unique, individually excited, two‐color, photoluminescence (PL) emissions at λ=495 and 585 nm; this allows two‐color imaging of the same space just by changing the excitation wavelength in situ. Moreover, the two PL bands of the nanocomposite are orthogonal, which allows the discrimination of eight proteins just by recording the three‐channel optical signals of the single probe. The two PL bands of the PEI/MnZnS composite are capable of distinguishing eight proteins at 0.5 μM, whereas the three‐channel signals (two PL bands and light scattering) can discriminate these proteins at no less than 0.25 μM.
Approaches to Molecular Magnetic Materials from the Use of Cyanate Groups in Higher Oxidation State Metal Cluster Chemistry: Mn14 and Mn16
Authors: Alexandropoulos Dimitris I. , Papatriantafyllopoulou Constantina , Li Chaoran , Cunha‐Silva Luís , Manos Manolis J. , Tasiopoulos Anastasios J. , Wernsdorfer Wolfgang , Christou George , Stamatatos Theocharis C. 
Published: March 2013

AbstractThe initial employment of cyanato groups in higher oxidation state manganese cluster chemistry, in conjunction with the gem‐diolate form of di‐2‐pyridylketone or 2,6‐diacetylpyridine dioxime chelate ligands, has afforded structurally interesting MnII/III14 and MnII/III/IV16 clusters, respectively. In both complexes, the end‐on bridging cyanato groups show an obvious preference in binding through their O atom, a significantly different ligation than that for the homoatomic‐type N3– ligand. The Mn14 compound shows entirely visible out‐of‐phase signals below 5 K and large hysteresis loops below 2 K.
Total Synthesis of (+)‐Antofine and (–)‐Cryptopleurine
Authors: Ying Weijiang , Herndon James W. 
Published: March 2013

AbstractThe tylophorine alkaloid anticancer compounds antofine and cryptopleurine have been synthesized in optically active form. Both syntheses use optically pure α‐amino acids as the starting materials, require only seven steps from known 2‐ethynylpyrrolidine or 2‐ethynylpiperidine derivatives, and are free of protecting groups. The key steps include an alkyne hydration and a chromium–carbene‐complex‐based net [5 + 5]‐cycloaddition step. The alkyne hydration was accompanied by racemization of the β‐amino ketone product under most of the conditions examined, and minimization of this side‐reaction was achieved through careful pH control and choice of metal additive. The final ring closure involved a Bischler–Napieralski reaction using a carbamate (antofine) or urea (cryptopleurine) precursor.
Electrochemical Characterization and Degradation Analysis of Large SOFC Stacks by Impedance Spectroscopy
Authors: Mosbæk R. R. , Hjelm J. , Barfod R. , Høgh J. , Hendriksen P. V. 
Published: March 2013

AbstractAs solid oxide fuel cell (SOFC) technology is moving closer to a commercial break through, lifetime limiting factors, and methods to measure the “state‐of‐health” of operating cells and stacks are becoming of increasing interest. This requires application of advanced methods for detailed electrochemical characterization during operation.An experimental stack with low ohmic resistance from Topsoe Fuel Cell A/S was characterized in detail using electrochemical impedance spectroscopy (EIS). An investigation of the optimal geometrical placement of the current feeds and voltage probes was carried out in order to minimize measurement errors caused by stray impedances. Three different stack geometries were investigated by impedance spectroscopy and the stack geometry with the minimum effect of stray impedances was selected.A 13‐cell experimental SOFC stack was tested during 2,500 h of operation with hydrogen as fuel with 52% fuel utilization and constant current load (0.2 A cm–2) at 750 °C. Stack interconnects were coated with six different coatings to prevent chromium poisoning on the cathode side. Four repeating units (RUs) with different coatings were selected for detailed impedance analysis. EIS allowed a distinction to be made in terms of the degradation between the four RU types that is not possible from IV‐data only.
In Situ X‐Ray Diffraction and Stress Analysis of Solid Oxide Fuel Cells
Authors: Wolf S. , Cañas N. A. , Friedrich K. A. 
Published: March 2013

AbstractTo increase the long term stability and performance of solid oxide fuel cell (SOFC) materials, it is important to understand the main degradation processes in their functional layers. In this work, the interface between electrolyte and anode material was investigated by in situ X‐ray diffraction (XRD) stress and phase analysis. It has been found that the determining process for the initial degradation of SOFC is the reduction of the anode material with hydrogen. During this process a tensile strength of 600–700 MPa is measured. These stresses are induced in the electrolyte material and produce crack networks. The reduction from nickel oxide to pure nickel was monitored by in situ phase analysis. This reaction induces tensile stress at the interface between electrolyte and anode. The stress produced in the electrolyte material was also confirmed by the observation of crack networks detected using scanning electron microscopy (SEM). Finally, the reducing process was optimized using different process gases, decreasing the destructive tensile stress level.
Incremental Value of a Futures Hedge Using Realized Ranges
Authors: Sheu Her‐Jiun , Lai Yu‐Sheng 
Published: March 2013

AbstractThis study investigates the information content of realized ranges for futures hedging. Hedge ratio estimation using generalized autoregressive conditional heteroscedasticity (GARCH) models augmented with intraday price range is proposed. Empirical investigations using the S&P 500 equity index data show that the in‐sample fitting of spot–futures distribution is improved by the information recovered from intraday price ranges. Furthermore, the out‐of‐sample forecasting results show that both the statistical and economic hedging effectiveness increase with the inclusion of intraday price ranges along with intraday and daily price returns. Results indicate that informative realized ranges are valuable for futures hedging. © 2013 Wiley Periodicals, Inc. Jrl Fut Mark 34:676–689, 2014
Rapid eruption of the Ningwu volcanics in eastern China: Response to Cretaceous subduction of the Pacific plate
Authors: Tang Yan‐Jie , Zhang Hong‐Fu , Ying Ji‐Feng , Su Ben‐Xun , Li Xian‐Hua , Santosh M. 
Published: March 2013

AbstractThe relationship between lithospheric evolution of eastern Eurasia and subduction of the Pacific plate has long been debated. However, the timing and implications of subduction on the tectonics of eastern China are not well constrained. Here we present new zircon U‐Pb ages and Hf isotopes, elemental and Sr‐Nd‐Pb isotopic data on Cretaceous volcanic rocks from the Ningwu basin, eastern China to further address this issue. Our age data reveal rapid eruption of the volcanic rocks within a short duration from 133 to 130 Ma. The rocks, mostly characterized by shoshonitic and high‐K calc‐alkaline signatures, display light rare earth element and Pb enrichment, Nb, Ta and Ti depletion, highly radiogenic Sr‐Pb isotopic ratios and variable εHf(t) (+1.8 to −10), suggesting derivation from an enriched lithospheric mantle metasomatized by marine sediments. The early lavas (133.3 ± 1.1 Ma) show stronger subduction‐related signatures than the late lavas (130.1 ± 1.0 Ma), which we interpret to reflect consumption of a significant volume of fusible subducted components in the early melting phase. The large εHf(t) variation of late lavas suggests greater involvement of asthenospheric melts and lower crust in their petrogenesis. The youngest age (130 Ma) appears to coincide with an inferred change in the direction of Pacific‐Eurasia convergence, manifested as a change from extension to transpression in eastern China. The narrow window of eruption may signify a rapid change of the tectonic regime in the Early Cretaceous.
Recent 121‐year variability of western boundary upwelling in the northern South China Sea
Authors: Liu Yi , Peng Zicheng , Shen Chuan‐Chou , Zhou Renjun , Song Shaohua , Shi Zhengguo , Chen Tegu , Wei Gangjian , DeLong Kristine L. 
Published: March 2013

AbstractCoastal upwelling is typically related to the eastern boundary upwelling system, whereas the powerful southwest Asian summer monsoon can also generate significant cold, nutrient‐rich deep water in western coastal zones. Here we present a sea surface temperature record (A.D. 1876–1996) derived from coral Porites Sr/Ca for an upwelling zone in the northern South China Sea. The upwelling‐induced sea surface temperature anomaly record reveals prominent multidecadal variability driven by Asian summer monsoon dynamics with an abrupt transition from warmer to colder conditions in 1930, and a return to warmer conditions after 1960. Previous studies suggest the expected increase in atmospheric CO2 for the coming decades may result in intensification in the eastern boundary upwelling system, which could enhance upwelling of CO2‐rich deep water thus exacerbating the impact of acidification in these productive zones. In contrast, the weakening trend since 1961 in the upwelling time series from the northern South China Sea suggests moderate regional ocean acidification from upwelling thus a stress relief for marine life in this region.
Power spectra of infragravity waves in a deep ocean
Authors: Godin Oleg A. , Zabotin Nikolay A. , Sheehan Anne F. , Yang Zhaohui , Collins John A. 
Published: March 2013

AbstractInfragravity waves (IGWs) play an important role in coupling wave processes in the ocean, ice shelves, atmosphere, and the solid Earth. Due to the paucity of experimental data, little quantitative information is available about power spectra of IGWs away from the shore. Here we use continuous, yearlong records of pressure at 28 locations on the seafloor off New Zealand's South Island to investigate spectral and spatial distribution of IGW energy. Dimensional analysis of diffuse IGW fields reveals universal properties of the power spectra observed at different water depths and leads to a simple, predictive model of the IGW spectra. While sources of IGWs off New Zealand are found to have a flat power spectrum, the IGW energy density has a pronounced dependence on frequency and local water depth as a result of the interaction of the waves with varying bathymetry.
Loss of interneuron LTD and attenuated pyramidal cell LTP in Trpv1 and Trpv3 KO mice
Authors: Brown Travis E. , Chirila Anda M. , Schrank Benjamin R. , Kauer Julie A. 
Published: March 2013

ABSTRACTTRPV (transient receptor potential, vanilloid) channels are a family of nonselective cation channels that are activated by a wide variety of chemical and physical stimuli. TRPV1 channels are highly expressed in sensory neurons in the peripheral nervous system. However, a number of studies have also reported TRPV channels in the brain, though their functions are less well understood. In the hippocampus, the TRPV1 channel is a novel mediator of long‐term depression (LTD) at excitatory synapses on interneurons. Here we tested the role of other TRPV channels in hippocampal synaptic plasticity, using hippocampal slices from Trpv1, Trpv3 and Trpv4 knockout (KO) mice. LTD at excitatory synapses on s. radiatum hippocampal interneurons was attenuated in slices from Trpv3 KO mice (as well as in Trpv1 KO mice as previously reported), but not in slices from Trpv4 KO mice. A previous study found that in hippocampal area CA1, slices from Trpv1 KO mice have reduced tetanus‐induced long‐term potentiation (LTP) following high‐frequency stimulation; here we confirmed this and found a similar reduction in Trpv3 KO mice. We hypothesized that the loss of LTD at the excitatory synapses on local inhibitory interneurons caused the attenuated LTP in the mutants. Consistent with this idea, blocking GABAergic inhibition rescued LTP in slices from Trpv1 KO and Trpv3 KO mice. Our findings suggest a novel role for TRPV3 channels in synaptic plasticity and provide a possible mechanism by which TRPV1 and TRPV3 channels modulate hippocampal output. © 2013 Wiley Periodicals, Inc.
Mechanical allodynia in neuropathic pain. Where are the brain representations located? A positron emission tomography (PET) study
Authors: Peyron R. , Faillenot I. , Pomares F.B. , Le Bars D. , Garcia‐Larrea L. , Laurent B. 
Published: March 2013

AbstractBackgroundBrain areas involved in nociception have been repeatedly investigated. Therefore, brain responses to physiological pain conditions are well identified. The same is not true for allodynic pain in patients with neuropathic pain since the cortical reorganizations that are involved in the conversion of non‐noxious stimuli into painful sensations still remain unknown.MethodsThe present positron emission tomography (PET) study enrolled 19 patients with dynamic mechanical allodynia to brushing or to cold rubbing of the skin. PET activations during allodynic stimulation were compared to those obtained with the same innocuous stimulation applied outside the neuropathic pain area (control). In a second comparison, they were compared with responses to a noxious heat stimulation applied outside the neuropathic pain area (experimental pain).ResultsCommon responses to allodynia and control stimulations were found in contralateral SI, SII and insula and in ipsilateral cerebellum. Not surprisingly, heat pain condition was associated with activations in contralateral prefrontal and SII cortices and, bilaterally, in the anterior insular cortices. Distinctive cortical responses between control and allodynic conditions were restricted to one activation within the contralateral anterior insula, a region also activated by experimental heat pain.ConclusionsThe insular subdivision was inappropriately activated considering the innocuous nature of the stimulus, but adequately activated with regard to pain‐evoked sensation. Subcortically, the hypothesis of reorganization at any level of the somatosensory and pain pathways underlying such insular activity was supported by the observed shift of thalamic activation from a lateral‐posterior to an anterior‐medial position.
Incidence and Costs of Adverse Drug Reactions in a Tertiary Care Pediatric Intensive Care Unit
Authors: Du Wei , Tutag Lehr Victoria , Caverly Mary , Kelm Lauren , Reeves Jaxk , Lieh‐Lai Mary 
Published: March 2013

ABSTRACTAdverse drug reactions (ADRs) increase morbidity, mortality, and hospital costs in children treated in the Pediatric Intensive Care Unit (PICU). Few studies have reported the incidence and risk factors of ADRs in PICU. Our study aimed to evaluate incidence, risk factors, and economic burden of ADRs in PICU. An intensive ADR surveillance was conducted at the PICU of Children's Hospital of Michigan between November 1, 2010 and May 31, 2011. A trigger list was used to screen for suspected ADR cases. Of the 697 consecutive PICU admissions reviewed, 13.1% experienced at least one episode of ADR. The ADR incidence was 22% in patients with cardiovascular (CV) surgery and 11.5% in other patients. The most frequently detected ADR was electrolyte imbalance associated with diuretic exposure. Mean age at admission was 4 years (interquartile range: 9 months–13 years). Risk factors for ADR included young age (<1 year), Pediatric Risk of Mortality (PRISM) score upon admission ≥3, and administration of ≥16 medications. ADRs increased total ICU costs by 3.5‐fold and length of ICU stay by 3.8‐fold. Increased ADR surveillance of high risk patients in conjunction with early intervention may reduce drug related morbidity and costs in the PICU.
Color Doppler sonography as an adjunct to repeat uterine evacuation for gestational trophoblastic disease: Case report
Authors: Tsuyoshi Hideaki , Sugita Genki , Kurokawa Tetsuji , Yoshida Yoshio 
Published: March 2013

ABSTRACTRepeat uterine evacuation is a therapeutic option for preserving fertility in patients with gestational trophoblastic neoplasms and chemoresistance, but remains controversial due to the risks of hemorrhage and perforation. A 25‐year‐old patient with low‐risk gestational trophoblastic neoplasm became chemoresistant; however, chemotherapy reduced intrauterine tumor vascularity as observed by color Doppler sonography, suggesting that patients could undergo uterine evacuation without major risk of bleeding. After 18 months, she achieved a normal pregnancy. Serial assessment of tumor vascularity with color Doppler sonography may provide information regarding the appropriate time to perform a repeat uterine evacuation without significant bleeding. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound 41:54–58, 2013
Contrast‐enhanced sonography for screening of vascular complication in recipients following living donor liver transplantation
Authors: Lee So Jung , Kim Kyoung Won , Kim So Yeon , Park Yang Shin , Lee Jeongjin , Kim Hyoung Jung , Lee Jong Seok , Song Gi Won , Hwang Shin , Lee Sung‐Gyu 
Published: March 2013

ABSTRACTThe purpose of this article is to discuss the role of CEUS for screening of vascular complication in recipients admitted to ICU following LDLT, effect of microbubble contrast agent on Doppler phenomenon, CEUS technique, and illustrate CEUS findings in recipients with complication following LDLT. CEUS can enhance the role of US in the diagnosis of postoperative vascular complication in recipients following living donor liver transplantation at the bedside. © 2013 Wiley Periodicals, Inc. J Clin Ultrasound, 41:305–312, 2013
Hydrologic profiling for greenhouse gas effluxes from natural grasslands in the prairie pothole region of Canada
Authors: Creed Irena F. , Miller Johnston , Aldred David , Adams Jennifer K. , Spitale Salvatore , Bourbonniere Rick A. 
Published: March 2013

AbstractThe prairie pothole physiographic region of North America is likely to be affected by climate change, and it is important to establish its baseline global warming potential as a basis for assessing global change effects. This study estimated the hydrologic effects on soil greenhouse gas efflux during the growing season along hydrologic profiles within natural prairie potholes ranging from the southern to northern limits of the prairie pothole region within central Canada. Soil moisture was found to be an important driver of differences in soil efflux along the hydrologic profiles and along the south‐to‐north gradient. The position of peak cumulative soil efflux varied along the hydrologic profile, with the N2O peak occurring at the backslope, the CO2 peaks at footslope and toeslope, and the CH4 peaks at toeslope and surface waters. When cumulative soil efflux was converted to global warming potential (Mg CO2 eq), the largest values were restricted to the narrow land‐water interface in the south but expanded to a broader area of the hillslope in the north. CO2 was the major (> 95%) contributor to global warming potential. Omitting hydrologic controls on greenhouse gas fluxes from estimates of global warming potential led to substantial underestimates of the contributions of N2O and CH4. Arid regions in the south had smaller global warming potential than wetter regions in the north. If future climate projections for a warmer, drier climate in this region are realized, global warming potential from soil greenhouse gas fluxes will be smaller in this landscape, because the changing hydrologic conditions should result in a reduction of global warming potential from land surfaces, even as global warming potential from surface waters increases.
Histopathology of lung adenocarcinoma based on new IASLC/ATS/ERS classification: Prognostic stratification with functional and metabolic imaging biomarkers
Authors: Lee Ho Yun , Jeong Ji Yun , Lee Kyung Soo , Yi Chin A. , Kim Byung‐Tae , Kang Hee , Kwon O Jung , Shim Young Mog , Han Joungho 
Published: March 2013

PurposeTo correlate the results of histopathologic subtyping and grading of lung adenocarcinoma with maximum standardized uptake values (SUVmax) on positron emission tomography (PET)/computed tomography and apparent diffusion coefficient (ADC) values on diffusion‐weighted MRI (DWI).Materials and MethodsForty‐three patients were included. The SUVmax and mean ADC values of tumors were measured and correlated with the histologic subtypes and grades of lung adenocarcinomas based on the IASLC/ATS/ERS classification scheme. Disease‐free survival (DFS) was estimated by using the Kaplan‐Meier method, and the log‐rank test was used to evaluate differences among three histologic grades or subgroups classified with imaging biomarker study results.ResultsFive (12.5%) tumors belonged to low grade, 30 (70%) to intermediate grade, and 8 (18.5%) to high grade, and patients with low‐grade histology had lower risk of recurrence than those with intermediate‐ or high‐grade histology (P = 0.048). A significant difference in SUVmax and mean ADC values was observed among three histologic grades (Ps < 0.001). Regarding DFS, lower metabolic (PET) activity or higher functional (DWI) diffusivity showed longer DFS. When patients (n = 30; 70% of patients) with intermediate histologic grade were subgrouped in consideration of both SUVmax and mean ADC results, combining metabolic and functional criteria helped stratify patients more precisely (P = 0.006).ConclusionSUVmax and mean ADC value correlate well with the histologic grades in lung adenocarcinomas, and combining both imaging biomarker study results leads to more useful stratification of patients into different prognostic subsets than the results of each study. J. Magn. Reson. Imaging 2013;38:905–913. © 2013 Wiley Periodicals, Inc.
Prodromal autonomic symptoms and signs in Parkinson's disease and dementia with Lewy bodies
Authors: Postuma Ronald B. , Gagnon Jean‐Francois , Pelletier Amélie , Montplaisir Jacques 
Published: March 2013

ABSTRACTPathologic staging systems suggest that autonomic dysfunction may be an early manifestation of Parkinson's disease and dementia with Lewy bodies. However, direct evidence is limited, and no prospective studies have measured when autonomic dysfunction starts before disease. Patients with idiopathic rapid eye movement (REM) sleep behavior disorder are at very high risk of developing neurodegenerative synucleinopathy, providing an opportunity to directly observe the development of autonomic dysfunction from prodromal stages of neurodegeneration. Patients with idiopathic REM sleep behavior disorder were followed annually in a prospective cohort that was established in 2004. Urinary, orthostatic, erectile, and constipation symptoms and systolic blood pressure drop from lying to standing were assessed annually. Patients who eventually developed defined synucleinopathy were compared with age‐matched controls. The evolution of autonomic measures was assessed with regression analysis to determine when markers first deviated from control values. Sensitivity and specificity of autonomic markers for identification of prodromal disease were calculated. Of 91 patients, 32 developed disease. In prodromal stages, there was substantial autonomic dysfunction observable at least 5 years before diagnosis. On regression analysis, autonomic dysfunction appeared to progress slowly over prodromal periods. The estimated onset of autonomic dysfunction ranged from 11 years to 20 years, and systolic drop (20.4 years) and constipation (15.3 years) had the earliest estimates. Systolic drop, erectile dysfunction, and constipation could identify disease up to 5 years before diagnosis with sensitivity ranging from 50% to 90%. By directly observing development of neurodegenerative synucleinopathy, we confirmed that autonomic dysfunction can occur early in neurodegenerative synucleinopathy, even as long as 20 years before defined disease. © 2013 Movement Disorder Society