bluuebunny/crossref_metadata_2025_split huggingface dataset:
ChemInform Abstract: Novel C2‐Symmetric Six‐Membered NHCs for Asymmetric Copper‐Catalyzed Conjugate Addition of Grignard Reagents to 3‐Methylhexenone.
Authors: Li Jie , Xu Liang 
Published: July 2015

AbstractA novel class enantiopure pyrimidinium‐based NHC precursors is designed, synthesized and successfully employed in Cu‐catalyzed asymmetric 1,4‐conjugate addition reactions.
ChemInform Abstract: Chiral Ureas and Thioureas Supported on Polystyrene for Enantioselective Aza‐Henry Reactions under Solvent‐Free Conditions.
Authors: Pedrosa Rafael , Andres Jose M. , Avila Deisy P. , Ceballos Miriam , Pindado Rodrigo 
Published: July 2015

AbstractNovel bifunctional ureas and thioureas immobilized on sulfonylpolystyrene are synthesized and applied as chiral organocatalysts in Aza‐Henry reactions.
ChemInform Abstract: Selective Aldol Condensation or Cyclotrimerization Reactions Catalyzed by FeCl3.
Authors: Arias‐Ugarte Renzo , Wekesa Francis S. , Findlater Michael 
Published: July 2015

AbstractAn unexpected cyclotrimerization of aldehydes is observed at low temperature in the presence of water to form 1,3,5‐trioxanes (II) in good yields.
ChemInform Abstract: Decarboxylative Halogenation of Indolecarboxylic Acids Using Hypervalent Iodine(III) Reagent and Its Application to the Synthesis of Polybromoindoles.
Authors: Hamamoto Hiromi , Miki Yasuyoshi , Umemoto Hideaki , Umemoto Misako , Ohta Chiaki , Fujita Emi , Nakamura Akira , Maegawa Tomohiro 
Published: July 2015

AbstractDepending on the N‐protecting group of the substrate, the title reaction generally affords either 1‐(phenylsulfonyl)‐2,3‐dihaloindoles or 1‐methyl‐3,3‐dihalooxindoles.
ChemInform Abstract: Magnesium‐Promoted Reductive Acylation of Aromatic Conjugated Ynones Accompanying with Transposition of the Triple Bond.
Authors: Zhang Tianyuan , Takano Atsushi , Nishiyama Yutaro , Maekawa Hirofumi 
Published: July 2015

AbstractByproducts of type (IV) are obtained in most cases in less than 20% yield.
ChemInform Abstract: Gold(I)‐Catalyzed Decarboxylation of Propargyl Carbonates: Reactivity Reversal of the Gold Catalyst from π‐Lewis Acidity to σ‐Lewis Acidity.
Authors: Shen Ruwei , Yang Jianjun , Zhu Shugao , Chen Chao , Wu Luling 
Published: July 2015

AbstractIn the catalyzed decarboxylative etherification of propargyl carbonates the gold(I) catalyst shows a distinct σ‐acidity and propargyl ethers are furnished.
ChemInform Abstract: Transition Metal‐Free Generation of N‐Unsubstituted Imines from Benzyl Azides: Synthesis of N‐Unsubstituted Homoallylic Amines.
Authors: Pramanik Suman , Reddy Reddy Rajasekhar , Ghorai Prasanta 
Published: July 2015

AbstractUsing tBuOK in stoichiometric as well as catalytic amounts and with slight modifications (temperature, solvent), a variety of benzyl and cinnamyl azides can be transformed into the corresponding homoallylic amines.
ChemInform Abstract: Nickel‐Catalyzed Reductive Benzylation of Aldehydes with Benzyl Halides and Pseudohalides.
Authors: Panahi Farhad , Bahmani Marzieh , Iranpoor Nasser 
Published: July 2015

AbstractFor the first time 1,2‐addition of aromatic and aliphatic aldehydes to benzylic substrates furnishes alcohols in presence of a nickel catalyst.
ChemInform Abstract: 3‐Methyl‐4‐oxa‐5‐azahomoadamantane as an Organocatalyst for the Aerobic Oxidation of Primary Amines to Oximes in Water.
Authors: Yu Jiatao , Jin Yong , Lu Ming 
Published: July 2015

AbstractThis green and selective oxidation of amines gives E‐type oximes in high yields.
ChemInform Abstract: Direct C—H Amidation of Benzoic Acids to Introduce meta‐ and para‐Amino Groups by Tandem Decarboxylation.
Authors: Lee Donggun , Chang Sukbok 
Published: July 2015

AbstractProcedure A) is found to be optimal for the introduction of an amino function in ortho‐position to the carboxylic acid by use of different sulfonyl azides.
ChemInform Abstract: Efficient Synthesis of Tertiary Acyclic Amides by the Chapman Rearrangement of Aryl Benzimidates in Ionic Liquids.
Authors: Epishina Margarita A. , Kulikov Alexander S. , Ignat'ev Nikolai V. , Schulte Michael , Makhova Nina N. 
Published: July 2015

AbstractThe Chapman rearrangement of aryl benzimidates (I) in ionic liquids affording the corresponding amides (II) is described.
ChemInform Abstract: Copper‐Catalyzed Radical Reaction of N‐Tosylhydrazones: Stereoselective Synthesis of (E)‐Vinyl Sulfones.
Authors: Mao Shuai , Gao Ya‐Ru , Zhu Xue‐Qing , Guo Dong‐Dong , Wang Yong‐Qiang 
Published: July 2015

AbstractThe method operates as the first step in the one‐pot two‐step synthesis of alkynes.
ChemInform Abstract: Nickel‐Catalyzed C—S Bond Formation: Synthesis of Aryl Sulfides from Arylsulfonyl Hydrazides and Boronic Acids.
Authors: Singh Rahul , Allam Bharat Kumar , Singh Neetu , Kumari Kumkum , Singh Satish Kumar , Singh Krishna Nand 
Published: July 2015

AbstractThioethers are prepared by cross—coupling of arylsulfonyl hydrazides and aryl boronic acids using a nickel catalyst.
ChemInform Abstract: An Efficient Method for the Preparation of Sulfonyl Chlorides: Reaction of Disulfides or Thiols with Sodium Hypochlorite Pentahydrate (NaOCl·5H2O) Crystals.
Authors: Okada Tomohide , Matsumuro Hiroaki , Iwai Toshiaki , Kitagawa Saori , Yamazaki Kento , Akiyama Tomomi , Asawa Tomotake , Sugiyama Yukihiro , Kimura Yoshikazu , Kirihara Masayuki 
Published: July 2015

AbstractOxidation of disulfides or thiols with sodium hypochlorite pentahydrate gives sulfonyl chlorides in an environmentally benign and economical manner.
ChemInform Abstract: Bulky Monodentate Biphenylarsine Ligands: Synthesis and Evaluation of Their Structure Effects in the Palladium‐Catalyzed Heck Reaction.
Authors: Quinteros Gisela J. , Uberman Paula M. , Martin Sandra E. 
Published: July 2015

AbstractA synthesis of biphenylarsines is presented and the utility of these products as ligand in Pd‐catalyzed Heck‐coupling reactions of activated olefins with aryl bromides and iodides is demonstrated.
ChemInform Abstract: Rhodium(III)‐Catalyzed Selective C—H Cyanation of Indolines and Indoles with an Easily Accessible Cyano Source.
Authors: Mishra Neeraj Kumar , Jeong Taejoo , Sharma Satyasheel , Shin Youngmi , Han Sangil , Park Jihye , Oh Joa Sub , Kwak Jong Hwan , Jung Young Hoon , Kim In Su 
Published: July 2015

AbstractA facile access to C‐7 cyanated indolines and C‐2 cyanated indoles using N‐cyano‐N‐phenyl‐para‐methylbenzenesulfonamide (II) as CN‐source is presented.
ChemInform Abstract: Direct Trifluoromethylation of Imidazoheterocycles in a Recyclable Medium at Room Temperature.
Authors: Ji Xiao‐Ming , Wei Liang , Chen Fan , Tang Ri‐Yuan 
Published: July 2015

AbstractA green trifluoromethylation of heterocycle‐fused imidazoles by sodium triflinate in an ionic liquid/water mixture is reported.
ChemInform Abstract: Thiazole Formation Through a Modified Gewald Reaction.
Authors: Mallia Carl J , Englert Lukas , Walter Gary C , Baxendale Ian R. 
Published: July 2015

AbstractDepending on the substitution of the α‐carbon to the cyano group of the nitrile educts, either 2‐substituted thiazoles or 2‐substituted aminothiophenes are obtained.
ChemInform Abstract: The Flavan—Isoflavan Rearrangement: Bioinspired Synthetic Access to Isoflavonoids via 1,2‐Shift—alkylation Sequence.
Authors: Nakamura Kayo , Ohmori Ken , Suzuki Keisuke 
Published: July 2015

Abstract(‐)‐Equol (X) is prepared in a 7‐step‐sequence.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Heck Coupling of Vinyl Pyridines with Aryl Boronic Acids.
Authors: Chen Shanshan , Zhang Xiuli , Chu Mingjie , Gan Xiaoping , Lv Xianhai , Yu Jie 
Published: July 2015

AbstractThe aryl vinyl pyridine cross‐coupling products (III) are obtained as single stereoisomer.
ChemInform Abstract: One‐Pot Synthesis of Symmetrical 2,6‐Diarylpyridines via Palladium/Copper‐Catalyzed Sequential Decarboxylative and Direct C—H Arylation.
Authors: Ma Zhiyong , Liu Hailong , Zhang Chunchun , Zheng Xueli , Yuan Maolian , Fu Haiyan , Li Ruixiang , Chen Hua 
Published: July 2015

AbstractA palladium(II)/copper oxide‐catalyzed one‐pot decarboxylative and direct C—H arylation of 2‐picolinic acid with aryl bromides is developed.
ChemInform Abstract: A New Protocol for Catalyst‐Free Regioselective Synthesis of 5,9‐Dihydropyrimido[5,4‐e][1,2,4]triazolo [1,5‐a]pyrimidine‐6,8(4H,7H)‐diones.
Authors: Karami Bahador , Farahi Mahnaz , Banaki Zohreh 
Published: July 2015

AbstractThe title compounds (IV) and (VI) are obtained by three‐component reaction of 1,3‐dimethylbarbituric acid (I), 3‐amino‐1H‐1,2,4‐triazoles (II) and (V), and various aromatic aldehydes (III) under solvent‐free reaction conditions.
ChemInform Abstract: An Operationally Simple Green Procedure for the Synthesis of Dihydropyrimido[4,5‐d]pyrimidinetriones Using CuI Nanoparticles as a Highly Efficient Catalyst.
Authors: Abdolmohammadi Shahrzad , Afsharpour Maryam 
Published: July 2015

AbstractCu nanoparticles are found to be an efficient catalyst for the three‐component reaction of 6‐aminouracil (I), aromatic aldehydes (II), and urea (III) in water to give the title compounds of type (IV).
ChemInform Abstract: An Efficient Synthesis of New Caffeine‐Based Chalcones, Pyrazolines and Pyrazolo[3,4‐b][1,4]diazepines as Potential Antimalarial, Antitrypanosomal and Antileishmanial Agents.
Authors: Insuasty Braulio , et al.  
Published: July 2015

AbstractSeveral title compounds of type (II), (IV), (VI), and (VIII) are prepared and tested for their biological activities.
ChemInform Abstract: Iridium‐Catalyzed Dehydrogenative Silylation of Azulenes Based on Regioselective C—H Bond Activation.
Authors: Murai Masahito , Takami Keishi , Takeshima Hirotaka , Takai Kazuhiko 
Published: July 2015

AbstractThe silylation of azulene with various hydrosilanes proceeds with excellent regioselectivity to form 2‐silylazulenes without the need for any directing groups.
ChemInform Abstract: Easy Access to (2‐Imidazolin‐4‐yl)phosphonates by a Microwave Assisted Multicomponent Reaction.
Authors: Abas Sonia , Estarellas Carolina , Javier Luque F. , Escolano Carmen 
Published: July 2015

AbstractAn atom‐economic and efficient method for the synthesis of title compounds such as (IV), (VII), and (IX) is reported.
ChemInform Abstract: New Septanoside and 20‐Hydroxyecdysone Septanoside Derivative from Atriplex portulacoides Roots with Preliminary Biological Activities
Authors: Ben Nejma Aymen , Nguir Asma , Ben Jannet Hichem , Hamza M'hamed Ali , Daich Adam , Othman Mohamed , Lawson Ata Martin 
Published: July 2015

Abstractisolation, structure determination as well as antioxidant, antibacterial, and anticholinesterase activities of portulasoid (I) and septanoecdysone (II)
ChemInform Abstract: Truncateols A—N, New Isoprenylated Cyclohexanols from the Sponge‐Associated Fungus Truncatella angustata with anti‐H1N1 Virus Activities.
Authors: Zhao Yang , Si Longlong , Liu Dong , Proksch Peter , Zhou Demin , Lin Wenhan 
Published: July 2015

AbstractFourteen novel isoprenylated cyclohexanols, e.g. compounds (I)‐(VIII), are isolated from the title fungus.
ChemInform Abstract: Photochemical Synthesis of Ultrafine Cubic Boron Nitride Nanoparticles under Ambient Conditions.
Authors: Liu Hui , Jin Peng , Xue Yan‐Ming , Dong Cunku , Li Xiang , Tang Cheng‐Chun , Du Xi‐Wen 
Published: July 2015

AbstractCubic BN nanoparticles with an average particle size of 3.5 nm are prepared by dehydrogenation of a dioxane solution of H3B·NH3 using a nanosecond or millisecond pulsed Nd:YAG laser (1064 nm, 10 min).
Atomic Layer Deposition of Hafnium(IV) Oxide on Graphene Oxide: Probing Interfacial Chemistry and Nucleation by using X‐ray Absorption and Photoelectron Spectroscopies
Authors: Alivio Theodore E. G. , De Jesus Luis R. , Dennis Robert V. , Jia Ye , Jaye Cherno , Fischer Daniel A. , Singisetti Uttam , Banerjee Sarbajit 
Published: July 2015

AbstractInterfacing graphene with metal oxides is of considerable technological importance for modulating carrier density through electrostatic gating as well as for the design of earth‐abundant electrocatalysts. Herein, we probe the early stages of the atomic layer deposition (ALD) of HfO2 on graphene oxide using a combination of C and O K‐edge near‐edge X‐ray absorption fine structure spectroscopies and X‐ray photoelectron spectroscopy. Dosing with water is observed to promote defunctionalization of graphene oxide as a result of the reaction between water and hydroxyl/epoxide species, which yields carbonyl groups that further react with migratory epoxide species to release CO2. The carboxylates formed by the reaction of carbonyl and epoxide species facilitate binding of Hf precursors to graphene oxide surfaces. The ALD process is accompanied by recovery of the π‐conjugated framework of graphene. The delineation of binding modes provides a means to rationally assemble 2D heterostructures.
Three‐Ring‐Based Room‐Temperature Bent‐Core Nematic Compounds: Synthesis and Characterization
Authors: Mohiuddin Golam , Punjani Vidhika , Pal Santanu Kumar 
Published: July 2015

AbstractWe report the synthesis and characterization of a new class of achiral three‐ring bent‐core compounds with an amide and ester linkage at the molecular bend, which are shown to exhibit nematic/phases in wide temperature ranges around room temperature (RT) and undulated SmC phases below RT. In contrast to previous studies, the compounds reported in this Communication show a true RT nematic phase with fluid physical appearance. They show strong photoluminescence in the mesophase and are found to display a one‐dimensional array of intermolecular hydrogen bonding. Furthermore, the nematic phases exhibited by these compounds show a good homeotropic alignment that can be exploited in applications such as optics and sensing. Considering the scarcity of bent‐core materials exhibiting an RT nematic mesophase, this new class of materials is promising.
Developmental changes in infant brain activity during naturalistic social experiences
Authors: Jones Emily J. H. , Venema Kaitlin , Lowy Rachel , Earl Rachel K. , Webb Sara Jane 
Published: July 2015

ABSTRACTBetween 6 and 12 months, typically developing infants undergo a socio‐cognitive “revolution.” The Interactive Specialization (IS) theory of brain development predicts that these behavioral changes will be underpinned by developmental increases in the power and topographic extent of socially selective cortical responses. To test this hypothesis, we used EEG to examine developmental changes in cortical selectivity for ecologically valid dynamic social versus non‐social stimuli in a large cohort of 6‐ and 12‐month‐old infants. Consistent with the Interactive Specialization model, results showed that differences in EEG Θ activity between social and non‐social stimuli became more pronounced and widespread with age. Differences in EEG activity were most clearly elicited by a live naturalistic interaction, suggesting that measuring brain activity in ecologically valid contexts is central to mapping social brain development in infancy. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 842–853, 2015.
A dual‐axis approach to understanding neuroendocrine development
Authors: Shirtcliff Elizabeth A. , Dismukes Andrew R. , Marceau Kristine , Ruttle Paula L. , Simmons Julian G. , Han Georges 
Published: July 2015

ABSTRACTThis introduction sets out to present a series of paper about a novel perspective regarding stress and sex hormones, or what the authors within this special issue term “coupling” of hypothalamic‐pituitary‐adrenal and—gonadal axes. This view postulates that these axes do not necessarily operate in opposition, but can operate together as evidenced empirically as a positive within‐person association between stress hormones like cortisol or sex hormones like testosterone. A wealth of papers within the special issue demonstrate positive coupling across acute, diurnal, basal, and longitudinal timeframes and across several different types of contexts. Reviews were meant to challenge whether this was physiologically plausible. Consistently, sophisticated statistical models were utilized in order to show a template for how to model positive coupling and to ensure that coupling was a within‐person phenomenon. We cautiously considered positive coupling until the consistency of observing coupling was robust enough for us to consider challenging the prevailing oppositional view of these axes. We do so to acknowledge that there are contexts, moments and stages in which the function of these axes should work together: for example when contexts are both stressful and challenging or at developmental stages (like adolescence) in which the youth must grow up despite the storm and stress of youth. We hope that by putting forward a functional dual‐axis approach, the field will be able to consider when and how these axes work together. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 57: 643–653, 2015.
Using the phenoscape knowledgebase to relate genetic perturbations to phenotypic evolution
Authors: Manda Prashanti , Balhoff James P. , Lapp Hilmar , Mabee Paula , Vision Todd J. 
Published: July 2015

SummaryThe abundance of phenotypic diversity among species can enrich our knowledge of development and genetics beyond the limits of variation that can be observed in model organisms. The Phenoscape Knowledgebase (KB) is designed to enable exploration and discovery of phenotypic variation among species. Because phenotypes in the KB are annotated using standard ontologies, evolutionary phenotypes can be compared with phenotypes from genetic perturbations in model organisms. To illustrate the power of this approach, we review the use of the KB to find taxa showing evolutionary variation similar to that of a query gene. Matches are made between the full set of phenotypes described for a gene and an evolutionary profile, the latter of which is defined as the set of phenotypes that are variable among the daughters of any node on the taxonomic tree. Phenoscape's semantic similarity interface allows the user to assess the statistical significance of each match and flags matches that may only result from differences in annotation coverage between genetic and evolutionary studies. Tools such as this will help meet the challenge of relating the growing volume of genetic knowledge in model organisms to the diversity of phenotypes in nature. The Phenoscape KB is available at http://kb.phenoscape.org. genesis 53:561–571, 2015. © 2015 Wiley Periodicals, Inc.
Challenging the two concepts in determining the appropriate pre‐discharge N‐terminal pro‐brain natriuretic peptide treatment target in acute decompensated heart failure patients: absolute or relative discharge levels?
Authors: Stienen Susan , Salah Khibar , Eurlings Luc W.M. , Bettencourt Paulo , Pimenta Joana M. , Metra Marco , Bayes‐Genis Antoni , Verdiani Valerio , Bettari Luca , Lazzarini Valentina , Tijssen Jan P. , Pinto Yigal M. , Kok Wouter E.M. 
Published: July 2015

AbstractAimsNT‐proBNP is a strong predictor for readmissions and mortality in acute decompensated heart failure (ADHF) patients. We assessed whether absolute or relative NT‐proBNP levels should be used as pre discharge treatment target.Methods and resultsOur study population was assembled from seven ADHF cohorts. We defined absolute (<1500, <3000, <5000, and <15 000 ng/L) and relative NT‐proBNP targets (>30, >50, and >70%). Population attributable risk fraction (PARF) is the proportion of all‐cause 6‐month mortality in the population that would be reduced if all patients attain the NT‐proBNP target. PARF was determined for each target as well as the percentage of patients attaining the NT‐proBNP target. Attainability was investigated by logistic regression analysis. A total of 1266 patients [age 74 (64–80), 60% male] was studied. For every absolute NT‐proBNP level, a corresponding percentage reduction was found that resulted in similar PARFs. The highest PARF (∼60–70%) was observed for <1500 or >70%, but attainability was low (27% and 22%, respectively). The strongest predictor for not attaining these targets was admission NT‐proBNP. In admission NT‐proBNP tertiles, PARFs were significantly different for absolute, but not for relative targets.ConclusionIn an ADHF population, pre‐discharge absolute or relative NT‐proBNP targets may both be useful as they have similar effects on PARF. However, depending on admission NT‐proBNP, absolute targets show varying PARFs, while PARFs for relative targets were similar. A relative target is predicted to reduce mortality consistently across the whole spectrum of ADHF patients, while this is not the case using a single absolute target.
Quantitative Analysis of a Promising Cancer Biomarker, Calretinin, by a Biosensing System Based on Simple and Effective Immobilization Process
Authors: Asav Engin , Sağıroğlu Ayten , Sezgintürk Mustafa Kemal 
Published: July 2015

AbstractCalretinin (CAL) is calcium binding protein, and its levels in blood and cerebrospinal fluids are increased, since its expression is increased various cancer types. A novel biosensor system fabricated by immobilization of a specific antibody to CAL, anti‐Calretinin (anti‐CAL), onto a gold electrode surface via an effective covalent binding method using mercaptohexanol, epichlorohydrin, and ethanolamine was reported for the sensitive, selective, and accurate analysis of CAL. The proposed biosensor showed a linear calibration range between 1 ng/mL and 5 ng/mL. LOD and LOQ values were determined as 0.11 ng/mL and 0.38 ng/mL, respectively. The standard deviation related to the reproducibility of the new biosensor system was calculated as 3.95 %. Lastly, in order to state the applicability of the biosensor to early diagnosis of CAL in practice, artificial serum samples spiked with CAL have been analyzed by the proposed biosensor.
Effect of Poly(amine)s on the Redox Properties of Carboxymethylcellulose and Ferrocene‐modified Poly(amine) Layer‐by‐Layer Films
Authors: Aikawa Yu , Watanabe Takumi , Minaki Daichi , Takahashi Shigehiro , Wang Baozhen , Anzai Jun‐ichi 
Published: July 2015

AbstractMultilayer films consisting of carboxymethylcellulose (CMC) and ferrocene‐modified poly(ethyleneimine) (Fc‐PEI) or poly(allylamine hydrochloride) (Fc‐PAH) were successfully prepared on a gold electrode to examine their redox properties. The redox current of (Fc‐PEI/CMC)n film‐coated electrodes increased with the number of layers, while the (Fc‐PAH/CMC)n film‐coated electrodes exhibited increased response only for the first eight bilayers. The (Fc‐PEI/CMC)n and (Fc‐PAH/CMC)n films deposited on the surface of Fc‐free multilayer film‐coated electrodes also showed a redox response. The (PEI/CMC)5 film‐coated electrode showed redox responses in Fc‐PEI and Fc‐PAH solutions, confirming the uptake of the Fc‐polymers in the inner film. In contrast, the uptake of the Fc‐polymers in the (PAH/CMC)5 film was severely suppressed, suggesting that different permeability of (PEI/CMC)5 and (PAH/CMC)5 films.