bluuebunny/crossref_metadata_2025_split huggingface dataset:
Treponema denticola improves adhesive capacities of Porphyromonas gingivalis
Authors: Meuric V. , Martin B. , Guyodo H. , Rouillon A. , Tamanai‐Shacoori Z. , Barloy‐Hubler F. , Bonnaure‐Mallet M. 
Published: November 2012

SummaryPorphyromonas gingivalis, an important etiological agent of periodontal disease, is frequently found associated with Treponema denticola, an anaerobic spirochete, in pathogenic biofilms. However, interactions between these two bacteria are not well understood at the molecular level. In this study, we seek to link the influence of T. denticola on the expression of P. gingivalis proteases with its capacities to adhere and to form biofilms. The P. gingivalis genes encoding Arg‐gingipain A (RgpA), Lys‐gingipain (Kgp), and hemagglutinin A (HagA) were more strongly expressed after incubation with T. denticola compared with P. gingivalis alone. The amounts of the three resulting proteins, all of which contain hemagglutinin adhesion domains, were increased in culture supernatants. Moreover, incubation of P. gingivalis with T. denticola promoted static and dynamic biofilm formation, primarily via a time‐dependent enhancement of P. gingivalis adhesion capacities on bacterial partners such as Streptococcus gordonii. Adhesion of P. gingivalis to human cells was also increased. These results showed that interactions of P. gingivalis with other bacterial species, such as T. denticola, induce increased adhesive capacities on various substrata by hemagglutinin adhesion domain‐containing proteins.
Visualization and Attentive Behavior for Pain Reduction during Radiofrequency Ablation of Atrial Fibrillation
Authors: NØRGAARD MARIANNE W. , WERNER ANETTE , ABRAHAMSEN RANDI , LARSEN BIRGITTE , DARMER METTE ROSENDAL , PEDERSEN PREBEN U. 
Published: November 2012

BackgroundRadiofrequency (RF) ablation of atrial fibrillation (AF) can be accompanied by pain and anxiety when light conscious sedation is used. We sought to determine how visualization and structured attentive behavior during ablation of AF could reduce pain intensity, spontaneously expressed pain, the amount of analgesics, anxiety, and adverse events.MethodsA clinical controlled study with 71 patients in a control group (CG), receiving conventional care and treatment, and 76 patients in an intervention group (IG), receiving relaxation and visualization, combined with a structured attentive behavior from staff.ResultsThere was no difference between CG and IG in perception of pain intensity at 15‐minute intervals; mean pain intensity: CG (0.00–2.90), IG (0.12–2.57), (NS), but patients spontaneously expressed pain less numbers of time outside fixed intervals in the IG: 1.4 ± 1.2 times (mean ± standard deviation [SD]) compared to CG: 2.8 ± 1.8 (P < 0.01). There was a statistically significant difference between the amount of analgesics (Fentanyl) used in the two groups: CG: 292.3 ± 107μg (mean ± SD) and IG: 220.7 ± 93μg (P < 0.0001). No effect was observed in perception of anxiety, mean anxiety: CG (0.10–1.84), IG (0.9–2.03)(NS), and the number of adverse events (P = 0.241).ConclusionVisualization and structured attentive behavior was shown to reduce the amount of analgesics during the RF ablation of AF. There was no difference in perception of pain intensity, but the patients spontaneously expressed pain significantly less numbers of times outside the scheduled measurements. There was no reduction in anxiety and numbers of adverse events.
Directional Preference Following Epidural Steroid Injection in Three Patients with Acute Cervical Radiculopathy
Authors: Desai Mehul J. , Padmanabhan Girish , Simbasivan Ajai , Kamanga‐Sollo Gladys G. , Dharmappa Ajay 
Published: November 2012

AbstractCervical radiculopathy is typically characterized by neurologic symptoms that are traced to disturbances of discrete spinal nerve root(s) due to inflammatory or mechanical etiologies. Here we present three patients diagnosed with cervical radiculopathy, whose directional preference only surfaced after either a cervical transforaminal or intralaminar nerve root epidural steroid injection.This retrospective observational case series describes three men who presented with cervical radiculopathy with 7‐9/10 neck pain, neck disability index (NDI) ranging between 44% and 90%, and an irreducible derangement upon McKenzie mechanical diagnosis and therapy (MMDT) evaluation. These patients demonstrated weaknesses, sensory changes, and/or decreased reflexes in the C5, C6, or C7 distributions. They each underwent a cervical transforaminal or intralaminar epidural injections at one or two levels, which uncovered their directional preference and facilitated further conservative treatment.These three patients experienced drastic improvements with each postinjection physical therapy session. They demonstrated decreased pain scores, centralization of pain, and a decreasing NDI trends throughout their treatments. They were all discharged with stable 0‐3/10 pain severity after four physical therapy sessions and NDI scores of 0%. These cases suggest an interplay between inflammatory and mechanical contributors to spine‐mediated pain and the treatment challenge this presents. Dissecting the components of spine pain can be challenging; however, delivery of skilled multidisciplinary care in an algorithmic fashion may be beneficial and provide the future framework for the management of cervical radiculopathy and other spine‐related conditions.
Is There Significant Correlation between Self‐Reported Low Back Pain Visual Analogue Scores and Low Back Pain Scores Determined by Pressure Pain Induction Matching?
Authors: Fishbain David A. , Lewis John E. , Gao Jinrun 
Published: November 2012

AbstractThe objective of this study was to determine whether self‐reported visual analogue scale (VAS) low back pain (LBP) scores are valid against matched psychophysically induced pressure pain scores.Two hundred thirty‐six chronic LBP patients (some with neck pain) reported their LBP and neck pain scores on a VAS immediately before psychophysical pressure pain induction used to determine pain threshold (PTHRE), pain tolerance (PTOL), and a psychophysical pressure pain score which matched (PMAT) their current LBP. Pearson Product‐Moment correlation coefficients were calculated between reported VAS neck scores, reported VAS LBP scores, and the psychophysically determined LBP PMAT scores. The PMAT scores were calculated utilizing PTOL only and both PTOL and PTHRE.There was a significant correlation between the LBP PMAT scores and the reported LBP VAS scores for both types of psychophysical LBP PMAT score calculations; however, there were insignificant correlations between the LBP PMAT scores and reported neck VAS scores.Chronic LBP patients can match their self‐reported VAS LBP scores to psychophysically determined LBP PMAT scores. As such, self‐reported VAS chronic LBP scores appear to be valid against one type of psychophysical measurement.
Validation of the Dutch Version of the DN4 Diagnostic Questionnaire for Neuropathic Pain
Authors: van Seventer Robert , Vos Cornelis , Giezeman Maurice , Meerding Willem‐Jan , Arnould Benoit , Regnault Antoine , van Eerd Maarten , Martin Carola , Huygen Frank 
Published: November 2012

AbstractDifficulties in diagnosing neuropathic pain in routine clinical practice support the need for validated and easy‐to‐use diagnostic tools. The DN4 neuropathic pain diagnostic questionnaire aims to discriminate neuropathic pain from nociceptive pain, but needs clinical validation. A total of 269 patients with chronic pain in three pain clinics were included in the study of which 248 had analyzable data. The mean duration of pain was 4.9 years. The most frequent etiologies were posttraumatic (36%), (pseudo) radicular (14%), and mechanical back pain (12%). The mean intensity of pain at visit was 5.6 on a 0–10 scale. Hundred and ninety‐six of 248 patients had an identical pain diagnosis from both physicians: 85 had neuropathic pain, 57 had nociceptive pain, and 54 had mixed pain. Among patients with identical diagnoses of neuropathic or nociceptive pain, using a receiver operating characteristic curve analysis, the area under the curve (AUC) was 0.81 for the DN4 7‐item and 0.82 for the 10‐item version. A cutoff point of 5/10 for the full questionnaire resulted in a sensitivity of 75% and a specificity of 79%, while a cutoff point of 4/7 for the partial questionnaire resulted in a sensitivity of 74% and a specificity of 79%. The items “brushing,” “painful cold,” and “numbness” were most discriminating. The DN4 is an easy‐to‐use screening tool that is reliable for discriminating between neuropathic and nociceptive pain conditions in daily practice. Item‐specific scores provide important information in addition to the total score.
The Influence of the Antiandrogen 2‐Hydroxyflutamide on the Androgen Receptor Expression in the Porcine Ovarian Follicles – An In Vitro Study
Authors: Duda M , Wolna A , Knapczyk‐Stwora K , Durlej‐Grzesiak M , Knet M , Tabarowski Z , Slomczynska M 
Published: November 2012

ContentsAndrogens are one of the most important agents influencing ovarian follicles growth and development. The biological action of androgens is primarily exerted through transcriptional regulation by the androgen receptor (AR), a member of the steroid hormone receptor superfamily. The purpose of this study was to test the role of androgen receptor agonist testosterone (T) or antagonist 2‐hydroxyflutamide (2‐Hf) and in combination on AR expression in cultured porcine granulosa cells (GC) or whole follicles. Granulosa cells isolated from mature pig follicles were cultured for 48 h. During the last 12 and 24 h of culture, they were incubated in the presence of T (10−7 m/ml), 2‐Hf (1.7 × 10−4 m) or both T and 2‐Hf (T + 2‐Hf, at the same concentrations as when added separately). To better imitate in vivo conditions, whole follicles (6–8 mm in diameter) isolated from porcine ovaries have been incubated (for 12 and 24 h) in an organ culture system with the addition of the same factors. Thereafter, cells or sections obtained from cultured follicles were processed for AR detection by immunocytochemistry or immunohistochemistry. Moreover, expression of AR mRNA and protein was determined by real‐time PCR and Western blot analysis. It was shown that the addition of 2‐Hf in the presence of T had a positive effect on AR mRNA and protein expression in porcine GC and ovarian follicles. Moreover, the addition of 2‐Hf influenced AR distribution in GC cultures which is seen as change of its localization from nuclear to perinuclear. Our results suggest that androgens acting through AR could be involved in the control of AR expression in porcine GC in vitro and in vivo.
Decreased activities of daily living is a strong risk factor for liver injury by anti‐tuberculosis drugs
Authors: Horita Nobuyuki , Miyazawa Naoki , Yoshiyama Takashi , Tsukahara Toshinori , Takahashi Ryohei , Tsukiji Jun , Kato Hideaki , Kaneko Takeshi , Ishigatsubo Yoshiaki 
Published: November 2012

AbstractBackground and objectiveWe evaluated the association between activities of daily living and drug‐induced liver injury by anti‐tuberculosis drugs.MethodsThis retrospective cohort study included adult inpatients with newly diagnosed smear‐positive lung tuberculosis treated with standard regimen in two hospitals. (n = 346; 63.6 ± 20.3 years old; 106 (30.6%) females). Activities of daily living was divided into ‘independent’ (Barthel Index (BI) 80–100, 60.4%) and ‘decreased’ (BI 0–75, 39.6%) categories. Liver injury was defined as the withdrawal or change of treatment regimen on the basis of the following criteria: serum transaminase concentrations were more than three times the upper limit of normal range with jaundice and/or hepatitis symptoms, or more than five times the upper limit of the normal range.ResultsCompared with ‘independent’ patients, patients with ‘decreased’ activities of daily living had odds ratios for liver injury of 4.2 (P < 0.001) in univariate analysis and 5.7 (P = 0.002) in logistic regression analysis after adjusting for other risk factors.ConclusionsDecreased activity of daily living is a strong risk factor for liver injury among adult inpatients with newly diagnosed smear‐positive lung tuberculosis treated using a standard regimen.
Ambulatory oximetry fails to predict survival in chronic obstructive pulmonary disease with mild‐to‐moderate hypoxaemia
Authors: TRAUER JAMES M. , GIELEN CHELSEA A. , AMINAZAD ALI , Steinfort Christopher L. 
Published: November 2012

AbstractBackground and objectiveAlthough long‐term oxygen therapy is one of few treatments known to improve survival in COPD, no patient subgroup likely to derive benefit has been identified in over 30 years. We assessed the prognostic value of point measurement of PaO2 and proportion of ambulatory oximetry with saturations below 90% in this context.MethodsSubjects were community‐living patients with COPD and PaO2 56–70 mm Hg when stable. Baseline assessments included clinical, physiological and laboratory assessments, as well as 24‐h ambulatory oximetry. Patients were followed to death from any cause, first exacerbation and first admission.ResultsDespite poor survival overall, there was no significant difference in prognosis between mildly hypoxaemic and moderately hypoxaemic patients. There were also no significant differences for secondary end–points (exacerbation and hospital admission). On multivariate analysis, trends were observed towards improved survival, with higher PaO2 and greater proportion of ambulatory oximetry below 90%.ConclusionsNeither resting PaO2 nor proportion of ambulatory oximetry below 90% saturation effectively predicted survival in COPD.
Sonographic assessment of changes in diaphragmatic kinetics induced by inspiratory resistive loading
Authors: Soilemezi Eleni , Tsagourias Matthew , Talias Michael A. , Soteriades Elpidoforos S. , Makrakis Vasilios , Zakynthinos Epaminondas , Matamis Dimitrios 
Published: November 2012

AbstractBackground and objectiveDiaphragmatic breathing patterns under resistive loading remain poorly documented. To our knowledge, this is the first study assessing diaphragmatic motion under conditions of inspiratory resistive loading with the use of sonography.MethodsWe assessed diaphragmatic motion during inspiratory resistive loading in 40 healthy volunteers using M‐mode sonography. In phase I of the study, sonography was performed during normal quiet breathing without respiratory loading. In phase II, sonography was performed after application of a nose clip and connection of the subjects to a pneumotachograph through a mouth piece. In phase III, the participants were assessed while subjected to inspiratory resistive loading of 50 cm H2O/L/s.ResultsCompared with baseline, the application of a mouth piece and nose clip induced a significant increase in diaphragmatic excursion (from 1.7 to 2.3 cm, P < 0.001) and a decrease in respiratory rate (from 13.4 to 12.2, P < 0.01). Inspiratory resistive loading induced a further decrease in respiratory rate (from 12.2 to 8.0, P < 0.01) and a decrease in diaphragmatic velocity contraction (from 1.2 to 0.8 cm/s, P < 0.01), and also an increase in tidal volume (from 795 to 904 mL, P < 0.01); diaphragmatic excursion, however, did not change significantly.ConclusionsInspiratory resistive loading induced significant changes in diaphragmatic contraction pattern, which mainly consisted of decreased velocity of diaphragmatic displacement with no change in diaphragmatic excursion. Tidal volume, increased significantly; the increase in tidal volume, along with the unchanged diaphragmatic excursion, provides sonographic evidence of increased recruitment of extradiaphragmatic muscles under inspiratory resistive loading.
Self‐transcendence, nurse–patient interaction and the outcome of multidimensional well‐being in cognitively intact nursing home patients
Authors: Haugan Gørill , Hanssen Brith , Moksnes Unni K. 
Published: November 2012

Aims and objectivesThe aim of this study was to investigate the associations between age, gender, self‐transcendence, nurse–patient interaction and multidimensional well‐being as the outcome among cognitively intact nursing home patients.BackgroundSelf‐transcendence is considered to be a vital resource of well‐being in vulnerable populations and at the end of life. Moreover, the quality of care and the nurse–patient interaction is found to influence self‐transcendence and well‐being in nursing home patients.Design and methodA cross‐sectional design employing the Self‐Transcendence Scale, the Nurse–Patient Interaction Scale, the FACT‐G Quality of Life and the FACIT‐Sp Spiritual Well‐Being questionnaires was adopted. A sample of 202 cognitively intact nursing home patients from 44 nursing homes in central Norway was selected. A previous documented two‐factor construct of self‐transcendence was applied. The statistical analyses were carried out by means of independent sample t‐test, correlation and regression analyses.ResultsMultiple linear regression analyses revealed significant relationships between interpersonal self‐transcendence and social, functional and spiritual well‐being, whereas intrapersonal self‐transcendence significantly related to emotional, social, functional and spiritual well‐being. Nurse–patient interaction related to physical, emotional and functional well‐being. Age and gender were not significant predictors for well‐being, except for functional and spiritual well‐being where women scored higher than men.ConclusionNurse–patient interaction and self‐transcendence are vital resources for promoting well‐being physically, emotionally, functionally, socially and spiritually among cognitively intact nursing home patients.Relevance to clinical practiceNurse–patient interaction signifies vital and ultimate nursing qualities promoting self‐transcendence and multidimensional well‐being. These findings are important for clinical nursing intending to increase patients’ well‐being.
Sex Differences in the Relationship between Harsh Discipline and Conduct Problems
Authors: Lysenko Laura J. , Barker Edward D. , Jaffee Sara R. 
Published: November 2012

AbstractResearch on sex differences in antisocial behaviour may shed light on the causes of childhood antisocial behaviour. Using a longitudinal design, we tested whether there were sex differences in the amount of harsh discipline children received or in the effect of harsh discipline and whether this accounted for sex differences in later conduct problems. Our sample was a representative, longitudinal sample of 13 830 twins born in England and Wales between 1994 and 1996. Results showed that boys experienced more harsh discipline than girls and that the sex difference in harsh discipline accounted for 10 percent to 20 percent of the sex difference in conduct problems. We found no evidence that harsh discipline had a greater effect on boys vs. girls. We also found evidence of a bidirectional relationship between harsh discipline and child conduct problems. These findings were replicated within families, automatically controlling for between‐families confounding factors.
Actinomyces bowdenii ulcerative keratitis in a dog
Authors: Sherman Amanda , Daniels Joshua B. , Wilkie David A. , Lutz Elizabeth 
Published: November 2012

AbstractA 5‐year‐old spayed female diabetic mixed‐breed dog underwent phacoemulsification and intraocular lens implantation to correct bilateral hypermature cataracts. Two months postsurgery, the patient presented with ulcerative keratitis and multifocal stromal abscessation OD, which was controlled, but never resolved, with topical fluoroquinolone therapy. The patient re‐presented 2 months later with a new, raised, white gritty corneal opacity associated with hyperemia, chemosis, and blepharospasm OD. Cytology of the right cornea revealed filamentous bacteria, suggestive of Actinomyces spp. Actinomyces bowdenii was subsequently isolated in pure culture and identified via 16s rDNA sequencing. Actinomyces bowdenii has never before been described as a cause of ocular infection. An immunosuppressed corneal environment likely contributed to this opportunistic Actinomycosis. The infection was not controlled with fluoroquinolone therapy, and the isolate, in vitro, was resistant to three fluoroquinolones (ciprofloxacin, ofloxacin, and levofloxacin), which also has not been previously reported for this species of Actinomyces. A superficial keratectomy with conjunctival graft was employed to successfully manage the infection.
Conjunctival squamous cell carcinoma in a reindeer (Rangifer tarandus tarandus)
Authors: Gonzalez‐Alonso‐Alegre Elisa M. , Rodriguez‐Alvaro Alfonso , Martinez‐Nevado Eva , Martinez‐de‐Merlo Elena M. , Sanchez‐Maldonado Belen 
Published: November 2012

AbstractAn 8‐year‐old female adult reindeer (Rangifer tarandus tarandus) was referred to the Veterinary Hospital of Madrid for evaluation of a conjunctival mass on the left eye which had been present for about 2 months. A surgical excision was performed and biopsy material submitted for light microscopic evaluation which confirmed the diagnosis of conjuctival squamous cell carcinoma. Nuclear p53 immunolabeling was found in 52% of the neoplastic cells. Follow‐up examination at 12 months postsurgery did not reveal recurrence of this neoplasm. Conjunctival squamous cell carcinoma has not been reported previously in reindeer and seems to have similar characteristics to the one existing in bovine species.
Schwarzian differential equations and Hecke eigenforms on Shimura curves
Authors: Yang Yifan 
Published: November 2012

AbstractLet X be a Shimura curve of genus zero. In this paper, we first characterize the spaces of automorphic forms on X in terms of Schwarzian differential equations. We then devise a method to compute Hecke operators on these spaces. An interesting by-product of our analysis is the evaluation and other similar identities.
Proof of a positivity conjecture of M. Kontsevich on non-commutative cluster variables
Authors: Lee Kyungyong , Schiffler Ralf 
Published: November 2012

AbstractWe prove a conjecture of Kontsevich, which asserts that the iterations of the non-commutative rational map Fr:(x,y)→(xyx−1,(1+yr)x−1) are given by non-commutative Laurent polynomials with non-negative integer coefficients.
Representations of metaplectic groups I: epsilon dichotomy and local Langlands correspondence
Authors: Gan Wee Teck , Savin Gordan 
Published: November 2012

AbstractUsing theta correspondence, we classify the irreducible representations ofMp2nin terms of the irreducible representations ofSO2n+1and determine many properties of this classification. This is a local Shimura correspondence which extends the well-known results of Waldspurger forn=1.
Complete addition laws on abelian varieties
Authors: Arene Christophe , Kohel David , Ritzenthaler Christophe 
Published: November 2012

AbstractWe prove that under any projective embedding of an abelian variety A of dimension g, a complete set of addition laws has cardinality at least g+1, generalizing a result of Bosma and Lenstra for the Weierstrass model of an elliptic curve in ℙ2. In contrast, we prove, moreover, that if k is any field with infinite absolute Galois group, then there exists for every abelian variety A/k a projective embedding and an addition law defined for every pair of k-rational points. For an abelian variety of dimension 1 or 2, we show that this embedding can be the classical Weierstrass model or the embedding in ℙ15, respectively, up to a finite number of counterexamples for ∣k∣≤5 .