bluuebunny/crossref_metadata_2025_split huggingface dataset:
Three network design problems for community energy storage
Authors: Ghaddar Bissan , Ljubić Ivana , Qiu Yuying 
Published: July 2024

AbstractIn this article, we develop novel mathematical models to optimize utilization of community energy storage (CES) by clustering prosumers and consumers into energy sharing communities/microgrids in the context of a smart city. Three different microgrid configurations are modeled using a unifying mixed‐integer linear programming formulation. These configurations represent three different business models, namely: the island model, the interconnected model, and the Energy Service Companies model. The proposed mathematical formulations determine the optimal households' aggregation as well as the location and sizing of CES. To overcome the computational challenges of treating operational decisions within a multi‐period decision making framework, we also propose a decomposition approach to accelerate the computational time needed to solve larger instances. We conduct a case study based on real power consumption, power generation, and location network data from Cambridge, MA. Our mathematical models and the underlying algorithmic framework can be used in operational and strategic planning studies on smart grids to incentivize the communitarian distributed renewable energy generation and to improve the self‐consumption and self‐sufficiency of the energy sharing community. The models are also targeted to policymakers of smart cities, utility companies, and Energy Service Companies as the proposed models support decision making on renewable energy related projects investments.
High‐fidelity digital twins: Detecting and localizing weaknesses in structures
Authors: Löhner Rainald , Airaudo Facundo , Antil Harbir , Wüchner Roland , Meister Fabian , Warnakulasuriya Suneth 
Published: July 2024

AbstractAn adjoint‐based procedure to determine weaknesses, or, more generally, the material properties of structures is developed and tested. Given a series of load cases and corresponding displacement/strain measurements, the material properties are obtained by minimizing the weighted differences between the measured and computed values. The present paper proposes and tests techniques to minimize the number of load cases and sensors. Several examples show the viability, accuracy and efficiency of the proposed methodology and its potential use for high fidelity digital twins.
Postoperative Radiotherapy in Advanced Stage Squamous Cell Carcinoma Requiring Maxillectomy
Authors: Harley Randall J. , Spector Matthew E. , Wilke Christopher T. , Sridharan Shaum 
Published: July 2024

AbstractObjectiveTo evaluate whether postoperative radiotherapy (PORT) improves survival among patients who received maxillectomy for pT4aN0 maxillary gingival or hard palate squamous cell carcinoma (SCC) with respect to tumor size.Study DesignRetrospective analysis.SettingNational Cancer Database from 2004 to 2019.MethodsIncluded adult patients who received maxillectomy (partial, subtotal, or total) and neck dissection for treatment‐naive margin negative pT4aN0 SCC of the maxillary gingiva or hard palate. Adjusted for age, gender, race, insurance status, income, education, urban/rural, facility type, region, comorbidity index, tumor grade, and tumor extension. Inverse probability weights were incorporated into a multivariable Cox proportional hazards model. A priori post hoc subgroup analysis was performed according to tumor size.ResultsWe included 416 patients who underwent maxillectomy for pT4aN0 SCC of the maxillary gingiva or hard palate (mean [standard deviation] age, 71.5 [11.3] years; male, 190 [45.7%]; tumor size 2 cm, 362 [87%]). Overall, 49.3% of patients received PORT (205 patients). PORT was associated with a 50% improvement in survival compared to surgery alone (adjusted hazard ratio [aHR], 0.50; 95% confidence interval [95% CI], 0.32‐0.81). On subgroup analysis, PORT was associated with improved survival for tumors 2 cm (aHR, 0.47; 95% CI, 0.29‐0.77), but not for tumors < 2 cm (aHR, 1.15; 95% CI, 0.33‐4.08).ConclusionThe vast majority of patients with pT4aN0 bone‐invading SCC of the maxillary gingiva and hard palate benefit from PORT. Patients with tumors < 2 cm did not demonstrate a survival benefit from adjuvant treatment, suggesting that bony invasion alone may not be sufficient criteria for treatment escalation.
Myringoplasty Using Human Birth Tissue Allografts to Repair Large Tympanic Membrane Perforations
Authors: Alsup Nickolas A. , Davis Kyle P. , Richter Gresham T. , Hartzell Larry D. 
Published: July 2024

AbstractObjectiveExamine outcomes among a series of pediatric patients who underwent myringoplasty using human birth tissue (BT) for repair of large tympanic membrane (TM) perforations.Study DesignCase series.SettingSingle‐institution pediatric hospital.MethodsRetrospective chart review of patients treated with BT during a 4‐year study period. Subjects who underwent myringoplasty for large (size 40% or greater) TM perforations were included for this study. Patients with a stable perforation of at least 1 month's duration preoperatively who then followed up for at least 3 months postoperatively met inclusion criteria.ResultsSix subjects were included in this study. One subject underwent bilateral repair; thus, this series includes a total of 7 perforations. TM perforations ranged from 40% to 70% of the TM. At initial follow‐up (median of 2 months), 5 of the 7 perforations had healed. One of these 5 had evidence of a 10% recurrent perforation at 5 months, which subsequently healed. Of the 2 patients not healed at initial follow‐up, 1 had only a residual pinpoint perforation that subsequently healed; the other had a persistent 30% perforation that was possibly related to their postoperative recovery period, which was complicated by a respiratory viral illness.ConclusionFor large TM perforations, myringoplasty with BT grafts may be a viable alternative to longer, more invasive procedures like tympanoplasty. Larger, randomized, prospective studies are needed.
Risk Factors for Replacement of Tympanostomy Tubes After Surgical Removal for Pediatric Patients
Authors: Wie Kathryn , Shah Shalini , Allen Paul , Castle Michael , McKenna Margo , Faria John 
Published: July 2024

AbstractObjectivesEar tube removal and patch myringoplasty are frequently performed. The indication and timing for surgery varies among otolaryngologists. This study identifies risk factors associated with the need for the replacement of tympanostomy tubes after tube removal and myringoplasty.Study DesignCase series with chart review.SettingSingle institution academic otolaryngology practice.MethodsPatients younger than 12 years of age who underwent tympanostomy tube removal and myringoplasty at the University of Rochester Medical Center from March 2011 to September 2019. Patients with tympanostomy tube removal due to chronic otorrhea were excluded.ResultsOne hundred sixty‐one patients (230 ears) met inclusion criteria and had sufficient follow‐up. Myringoplasty success after tube removal was 94.8%. Successful myringoplasty was associated with shorter tube duration (32 months) versus unsuccessful myringoplasty (40 months) (P = .02). Replacement tympanostomy tubes after myringoplasty occurred in 9.6% of ears. There was no difference in average patient age (P = .96) or duration of tubes (P = .74) in patients who required replacement of tympanostomy tubes versus patients who did not require tube replacement. Patients with a cleft abnormality were more likely to require tympanostomy tube replacement (P < .001).ConclusionsMost children do not need tubes replaced after removal. This study identified cleft abnormality as a factor that increased the need for replacement tubes. Longer tube durations of over 3 years negatively impacted myringoplasty success. Tympanostomy tube removal should be considered 2 to 3 years after placement in most patients with longer tube durations considered in children with a repaired cleft palate.
Photoconductivity of explosive percolation in conductive polymer/graphene oxide nanocomposite films
Authors: Telfah Ahmad D. , Al‐Bataineh Qais M. , Ahmad Ahmad A. , Aljarrah Ihsan , Al‐Essa Khansaa , Houshmand Milad , Etzkorn Johannes , Appel Tamara 
Published: July 2024

AbstractIn this study, we explored the behavior of protonated polyaniline/graphene oxide (PANI‐CSA/GO) nanocomposite films with varying GO concentrations, focusing on the novel phenomenon of explosive percolation. We observed a significant increase in electrical conductivity at the explosive percolation threshold, attributed to the emergence of a percolating metallic pathway. This discovery positions PANI‐CSA/GO films as promising materials for various electronic and electrical engineering applications. Additionally, the films demonstrated consistent and repeatable photoconductivity, showing potential for use in high‐performance UV‐photodetectors, photoactive layers in solar cells, light‐emitting diodes, and energy storage devices. Structural analyses using fourier transform infrared spectroscopy (FTIR) and x‐ray diffraction (XRD) confirmed successful GO incorporation within the PANI‐CSA matrix. Different morphological features were observed depending on the GO volume fraction, with increased GO enhancing thermal stability in the conductive zone. Our findings highlight the immense potential of PANI‐CSA/GO nanocomposite films in advanced electronic applications, emphasizing their novel conductive and photoconductive properties and improved thermal stability.
Experimental study on compression properties of composite aluminum honeycomb sandwich structures
Authors: Niu Weijing , Yan Xiaopeng , He Qi , Guo Zhangxin 
Published: July 2024

AbstractThe mechanical properties of the carbon fiber and glass fiber composite honeycomb sandwich structure were studied through compression experiments. The influence of different aluminum honeycomb edge lengths, upper and lower panel thickness, aluminum honeycomb thickness, and loading speed on the compression failure load of carbon fiber composite laminates sandwich structure is analyzed. The influence of different aluminum honeycomb edge lengths and thicknesses on the compression failure load of glass fiber composite laminates sandwich structure was studied. The results show that the thickness of the panel has a significant effect on the failure load of the carbon fiber composite laminate sandwich structure, and the loading speed has a significant effect on the failure load of the carbon fiber composite laminate sandwich structure. The greater the loading speed, the greater the value of the failure load. The edge length and thickness of the aluminum honeycomb have a certain effect on the damage load of the carbon fiber composite laminates sandwich structure, but the influence on the mechanical properties of the glass fiber composite laminates sandwich structure is much greater.Highlights
The compression performance of composite sandwich structures was experimentally studied.
The influence of composite panel thickness was studied.
The influence of aluminum honeycomb edge length and thickness was studied.
The influence of loading speed was studied.
Effect of impact position on the mechanical response and viscoelastic behavior of double‐blade composite stiffened structures
Authors: Hu Chunxing , Xu Zhonghai , Cai Chaocan , Wu Shibao , Wang Rongguo , He Xiaodong 
Published: July 2024

AbstractThis paper focuses on the mechanical response and viscoelastic properties of double‐blade composite stiffened structure (DCSS) under low‐velocity impact (LVI). Firstly, the impact resistance and viscoelastic behavior of the DCSS are revealed by LVI testing at four different locations using the same initial velocity. Next, the damage morphologies at the impact locations are observed with ultrasonic A‐ and C‐scan equipment and optical microscopy. At last, the DCSS containing impact damage is implemented for axial compression and the strain values of the DCSS surface are obtained using a strain testing system to reveal its residual properties and buckling behavior. The results show that there are significant differences in the impact damage modes at the four different locations. The maximum impact resistance is observed at location D, while location A has the opposite. The DCSS has a certain viscoelastic behavior at LVI and conforms to an exponential decay model. Moreover, position B presents interface debonding damage due to stiffness discontinuities at the flange and skin bonding and severely weakens the load carrying performance of the DCSS.Highlights
The impact resistance of different positions is analyzed by LVI experimental results.
Viscoelastic properties exist at different impact locations and obey the exponential decay model.
Impact damage alters the buckling load and residual strength of the DCSS.
The damage mechanism of the triangular zone is revealed by damage morphology.
Registration of ‘Black Pearl’ black bean
Authors: Gomez Francisco E. , Kelly James. D. , Wright Evan M. , Awale Halima E. , Bales Scott 
Published: July 2024

Abstract‘Black Pearl’ black bean (Phaseolus vulgaris L.) (Reg. no. CV‐362, PI 705445), developed by Michigan State University AgBioResearch, was released in 2023 as an upright, full‐season cultivar with anthracnose resistance and superior canning quality. Black Pearl was developed using pedigree breeding method to the F4 generation followed by pure line selection for disease, agronomic, and quality traits. In 5 years of field trials, Black Pearl yielded 3372 kg ha−1, flowered in 47 days, and matured in 98 days on average. Plants averaged 46 cm in height, with lodging resistance score of 1.8 and seed weight of 21.9 g 100 seed−1. Black Pearl combines high yield potential with upright architecture and full‐season maturity in a black seed type. Black Pearl has resistance to lodging and high pod placement within the plant making it suitable for direct harvest under narrow row production systems. Black Pearl is resistant to races 7 and 73 of anthracnose, resistant to Bean common mosaic virus, and has shown better resistance to Rhizoctonia root rot than other black bean cultivars. Black Pearl produces seed that meets industry standards for export and packaging and was rated the highest in canned bean color in the black bean market class.
Combining SDS‐PAGE to capillary zone electrophoresis‐tandem mass spectrometry for high‐resolution top‐down proteomics analysis of intact histone proteoforms
Authors: Fang Fei , Gao Guangyao , Wang Qianyi , Wang Qianjie , Sun Liangliang 
Published: July 2024

AbstractMass spectrometry (MS)‐based top‐down proteomics (TDP) analysis of histone proteoforms provides critical information about combinatorial post‐translational modifications (PTMs), which is vital for pursuing a better understanding of epigenetic regulation of gene expression. It requires high‐resolution separations of histone proteoforms before MS and tandem MS (MS/MS) analysis. In this work, for the first time, we combined SDS‐PAGE‐based protein fractionation (passively eluting proteins from polyacrylamide gels as intact species for mass spectrometry, PEPPI‐MS) with capillary zone electrophoresis (CZE)‐MS/MS for high‐resolution characterization of histone proteoforms. We systematically studied the histone proteoform extraction from SDS‐PAGE gel and follow‐up cleanup as well as CZE‐MS/MS, to determine an optimal procedure. The optimal procedure showed reproducible and high‐resolution separation and characterization of histone proteoforms. SDS‐PAGE separated histone proteins (H1, H2, H3, and H4) based on their molecular weight and CZE provided additional separations of proteoforms of each histone protein based on their electrophoretic mobility, which was affected by PTMs, for example, acetylation and phosphorylation. Using the technique, we identified over 200 histone proteoforms from a commercial calf thymus histone sample with good reproducibility. The orthogonal and high‐resolution separations of SDS‐PAGE and CZE made our technique attractive for the delineation of histone proteoforms extracted from complex biological systems.
Molecular dynamics research on piperazine‐ and renewable cross‐linker‐based polyurethanes. Dielectric study of relaxation behavior
Authors: Potolinca Violeta Otilia , Asandulesa Mihai , Oprea Stefan 
Published: July 2024

AbstractBy using broadband dielectric spectroscopy over a wide frequency and temperature range, the effect of the chain extender and cross‐linkers on molecular dynamics of polyurethanes based on piperazine as a heterocyclic compound was assessed. Three relaxations attributed to local motions of polar side groups and small segments of the polyurethane chain (β, γ‐mode) and glass transition (α‐mode) were detected with the increase in temperature from −120 to 100 °C, along with the conductivity process at high temperatures and low frequencies. Experimental data were examined using the impedance and electric modulus for the conductivity study. Due to the presence of dipole polarization of functional groups in the hard segments, cross‐linked polyurethanes are characterized by higher dielectric constant value (≈11 at 1 kHz and 25 °C) compared to the linear ones (≈6–7 at 1 kHz and 25 °C). High conductivity was achieved for the Tween 20‐cross‐linked polyurethanes. The activation energy for the secondary γ relaxation was in the range of 34–37 kJ mol−1 for all polyurethanes, regardless of the chain extender or cross‐linker used. Piperazine‐based polyurethanes had lower activation energies for α relaxation and high conductivity compared to cyclohexane‐based polyurethanes. This indicates that α relaxation is more vulnerable to structural alterations.
Dupilumab 200 mg was efficacious in children (6–11 years) with moderate‐to‐severe asthma for up to 2 years: EXCURSION open‐label extension study
Authors: Phipatanakul Wanda , Vogelberg Christian , Bacharier Leonard B. , Dell Sharon , Altincatal Arman , Gall Rebecca , Ledanois Oliver , Sacks Harry , Jacob‐Nara Juby A. , Deniz Yamo , Rowe Paul J. 
Published: July 2024

AbstractBackgroundThe phase 3 VOYAGE (NCT02948959) and open‐label extension EXCURSION (NCT03560466) studies evaluated dupilumab in children (6–11 years) with uncontrolled moderate‐to‐severe asthma. This post hoc analysis assessed the efficacy and safety of add‐on dupilumab 200 mg every 2 weeks (q2w), the largest dose cohort in both studies, in children from VOYAGE who participated in EXCURSION.MethodsAnnualized rate of severe asthma exacerbations (AERs), change in prebronchodilator percent predicted forced expiratory volume in 1 s (ppFEV1), and treatment‐emergent adverse events were assessed in children with moderate‐to‐severe asthma who received dupilumab 200 mg q2w in VOYAGE and EXCURSION (dupilumab/dupilumab arm) and those who received placebo in VOYAGE and dupilumab 200 mg q2w in EXCURSION (placebo/dupilumab arm). These endpoints were also assessed in children with moderate‐to‐severe type 2 asthma (defined as blood eosinophil count ≥150 cells/µL or FeNO ≥20 ppb at the parent study baseline [PSBL]).ResultsIn the overall population, dupilumab reduced AER and improved prebronchodilator ppFEV1 in the dupilumab/dupilumab arm (n = 158) for up to 2 years. Children receiving placebo/dupilumab (n = 85) showed similar reductions after initiation of dupilumab 200 mg q2w in EXCURSION. Similar results were observed for children with type 2 asthma at PSBL. The safety profile was consistent with the known safety profile of dupilumab.ConclusionIn children (6–11 years) with uncontrolled moderate‐to‐severe type 2 asthma, dupilumab 200 mg reduced exacerbation rates and improved lung function for up to 2 years and showed safety consistent with the known dupilumab safety profile.
Identification and verification of KEAP1‐related genes and targets regulated by potential ingredients in KRAS mutant colorectal cancer
Authors: Wang Gang , Li Fei , Zhu Zhi Min , Wang Kun , Xu Xiao‐Na , Li Feng‐Qian 
Published: July 2024

AbstractAs one of the most prevalent tumors, colorectal cancer (CRC) owns complex pathogenesis and the high recurrence rate significantly influence the prognosis of patients with KRAS mutant CRC, to discovery the crosstalk among KEAP1‐NFE2L2 and oncogenic KRAS as the potential prognostic biomarkers in CRC, which might be used to develop novel and effective therapeutics. By using bioinformatics analysis, we explored and identified key genes as the predicted targets in the crosstalk among KEAP1 oncogenic signatures of KRAS mutation that were linked with development, metastasis, and poor prognosis in CRC. We further investigated the correlations between the clinical characteristics and expressions of prognostic genes among the KRAS and KEAP1‐related key hub genes in CRC, which as predicted targets to find the potential herbal ingredients in HERB database, further to verify the active herbal ingredients could regulate the key targets that related to KEAP1‐NFE2L2 in KRAS mutant CRC. The newest TCGA data reveals that the mutation of KRAS is found in 44% of CRC patients. In total, 28 genes were identified as differentially expressed genes (DEGs), and the hub genes such as CDKN2A, SPP1, FOS, BCL2L11, and HPSE were verified. Results indicated that key genes (SOX9, SPP1) significant correlation with the target prediction of the active herbal ingredients by molecular docking analysis. Furthermore, KEAP1, NFE2L2, SOX9 expression were decreased significantly with the treatment of potential ingredients. Furthermore, cyclopamine could enhance the sensitivity of HCT116 cells, downregulated the expression of SPP1, and induced activation of KEAP1‐NFE2L2 pathway, which cell death are characteristic features of apoptosis, and enhanced anticancer effect. Therefore, KEAP1‐related genes might be important oncogenic signatures in KRAS mutant CRC cells and cyclopamine was identified as a potential ingredient and regulated the predict targets of SOX9 and SPP1, may be expand the efficacy and range of novel and effective therapeutics.
Robotic versus open mini‐incision living donor nephrectomy: Single centre experience
Authors: Lee Seung Duk , Savsani Kush , Wang Sarah Ziqi , Bhati Chandra , Sambommatsu Yuzuru , Imai Daisuke , Khan Aamir , Saeed Irfan , Sharma Amit , Kumaran Vinay , Cotterell Adrian , Levy Marlon , Bruno David A. 
Published: July 2024

AbstractBackgroundRobotic surgery is associated with less tissue manipulation and earlier recovery with minimal incision. The aim of this study was to compare the short‐term clinical outcomes between robotic‐assisted donor nephrectomy (RDN) and open mini‐incision donor nephrectomy (ODN).MethodsFrom 2016 to 2019, 141 cases involving RDN were analysed. Patient outcomes were compared with those of 191 patients who underwent ODN from 2010 to 2015. Demographics, operation factors, perioperative outcomes, and complications were retrospectively reviewed.ResultsThe RDN group presented with less blood loss than the ODN group (p = 0.023). The length of hospital stay was significantly shorter in the RDN group than in the ODN group (p < 0.005). The overall rate of complications was low and there was no significant difference in complication rates between the groups.ConclusionThe robotic approach has benefits over the traditional open approach, including shorter length of hospital stay and reduced intraoperative blood loss.