bluuebunny/crossref_metadata_2025_split huggingface dataset:
WACANA MANTRA DUKUN BERANAK MELAYU RIAU
Authors: Mahyuni Iroy , Macaryus Sudartomo 
Published: July 2024

This study aims to describe (1) Content of mantra, (2) the form of mantra, (3) function, (4) inheritance of mantra Â Melayu Riau. This type of research is qualitative research. The data in this study a lingual unit that forms a spell Melayu Riau. The data used in this study is three, namely Datok Sodah, Nenek Lambiah, and Nenek Terima. The method of providing data in this study using records. Techniques providing data using the tapping technique. The validity of the data by using the extension of participation and persistence observations. Data analysis method used is the method of ethnography. The data analysis was done by using domain analysis. The results showed that (1) Content spell includes stages prenatal, childbirth and postnatal, which rejects interference, testimony, and plea. Tapahan prenatal can be viewed Kato landslide Dead Bedarah, Cus Sibalucus, Si Tampun-Tampun, Sireh Lillah, Eggplant Lillah, Oil Lillah, Dokon foursome, and Petandoan. Stages of the birth process, namely Ring Geligo Sea, Membukak Lawang (Datok Saodah), Membukak Lawang (Grandma Lambiah), Dokon Betujoh, Key Sire Ali, Wada Wadi Maknikam, Tetak Duri Tampong Duri, Officer King Ali, Selusoh carrion, Said Witness, if Dead Son, Birah Black (Datok Saodah), Sibalucus, Membukak Lawang (Grandma Accept), Tawa Stickiness Uri, Selusoh Slaves, Ketigo Chicken, Nature Teberakai, and Sindai Teruno. Sindai postnatal stages uno, Children Anjeng Kuyok Buto, invisibility Rayo, Senengkat, invisibility Chaff, Tiong Gano, Sirejang Anjeng, Birah Black (Grandma Lambiah), Salam Gumi, Hillahi Tegu, Origin Land, and Tawa Param. (2) Form spell, namely poetry, prose and free verse lyrics. (3) Function spells, which accelerates the process of birth, to overcome the difficulties in childbirth, birth overcome distorted, and the safety of women and their babies. (4) Inheritance spells Melayu Riau open to the public.
POSTMODERNISME DALAM SUPERNOVA (AKAR) KARYA DEWI LESTARI
Authors: Setyami Inung 
Published: July 2024

Â The research is focused on problems related to postmodern and postmodern studies. The data source in this study was the second episode of Supernova's novel, Akar, the first printed in 2002. The data were obtained by reading and taking notes. Analyzed by qualitative descriptive analysis techniques. The validity of the data is obtained through validity (semantic and referential) and reliability (interrater and intrarater). The results showed that Supernova: Akar is a postmodern work. Postmodernism in Supernova, namely: (1) The attitude of characters who long for locality and are disgusted by the establishment and freedom of the western world in the high-level modern era; (2) The emergence of primitivism, namely nomadic life at the peak of modern life; (3) The presenting of a supernatural world concerning a creature whose existence is visible to the eye but exists, namely a supernatural being; (4) The existence of an unclear place where its location and description is ontological dominant; (5) There is a method of "physical renewal or body shape", namely the addition of metal to the horned head, as a lifestyle; (6) The existence of a dream world which is also a real world.
Simulasi Bantuan Hidup Dasar (BHD) Berbasis Manekin dan Skenario untuk Meningkatkan Pengetahuan Mahasiswa Keperawatan dalam Penanganan Gawat Darurat
Authors: Inovasi Monica , Silvitasari Ika 
Published: July 2024

Latar Belakang: Kematian akibat henti jantung di dunia sebanyak 16,17% dari total kasus, dengan 245.343 kasus di Indonesia pada tahun 2023. Tingginya angka kematian inilah yang mengharuskan Mahasiswa keperawatan sebagai first responder minimal harus memiliki pengetahuan dan pengalaman dasar terkait BHD. Pengetahuan mahasiswa keperawatan yang masih kurang, mendasari perlunya pertolongan BHD yang benar sesuai prosedur guna meminimalkan angka kematian korban. Banyaknya metode tradisional yang telah digunakan, mengharuskan penelitian ini menggunakan metode yang lebih interaktif yaitu dengan Simulasi Berbasis Manekin dan Skenario. Tujuan: Mengetahui pengaruh simulasi Bantuan Hidup Dasar (BHD) terhadap pengetahuan mahasiswa keperawatan. Metode: Metode penelitian Quasy Experiment dengan jumlah sampel 126, tingkat pengetahuan diukur menggunakan kuesioner pengetahuan BHD yang sudah valid dan reliabel, kemudian di analisis menggunakan Uji Paired Sample T-Test. Pengambilan data pada penelitian ini dilakukan pada bulan Desember 2023 hingga bulan Juni 2024. Hasil: Tingkat pengetahuan sebelum dilakukan simulasi termasuk dalam kategori kurang (76%). Tingkat pengetahuan setelah dilakukan simulasi dalam kategori baik (94%). Terdapat pengaruh Tingkat pengetahuan sebelum dan sesudah dilakukan simulasi BHD dibuktikan dengan nilai p-value 0,001 < 0,05. Kesimpulan: Simulasi Bantuan Hidup Dasar (BHD) berbasis manekin dan skenario meningkatkan pengetahuan mahasiswa keperawatan dalam penanganan gawat darurat.
Pengaruh metode pembelajaran outdoor learning terhadap motivasi belajar IPS kelas IV SD Negeri Rejowinangun Utara 6
Authors: Febiyani Putri , Wardana Aditya Eska , Wijayanto Sukma 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh metode outdoor learning terhadap motivasi belajar IPS siswa kelas IV SD Negeri Rejowinangun Utara 6. Penelitian ini merupakan jenis penelitian Pra eksperimen dengan model One Group Pretest Posttest Design. Subjek penelitian dipilih menggunakan total sampling. Sampel yang diambil sebanyak 25 siswa. Metode pengumpulan data dilakukan dengan angket. Uji validitas menggunakan validitas isi yang dilakukan dengan validator berupa dosen dan guru kelas. Uji prasyarat analisis terdiri dari uji normalitas menggunakan bantuan SPSS Statistic for windows 25.0. Analisis data menggunakan teknik statistik parametrik yaitu Uji Pired Sample T-Test berbantuan program IBM Statistic for windows SPSS 25.0. Hasil penelitian menunjukkan bahwa metode outdoor learning berpengaruh positif terhadap motivasi belajar pada mata pelajaran IPS. Hal ini dibuktikan dari hasil analisis Uji Pired Sample T-Test dengan probabilitas nilai sig (2-tailed) 0,000 < 0,05. Berdasarkan hasil analisis dan pembahasan, terdapat perbedaan skor yaitu 7,72 dari rata-rata pretest sebesar 73.08 dan posttest sebesar 80,8. Hasil dari penelitian ini dapat disimpulkan bahwa penggunaan metode outdoor learning berpengaruh positif terhadap motivasi belajar IPS
Existence and non-existence results to a mixed anisotropic Schrödinger system in a plane
Authors: Hajaiej Hichem , Kumar Rohit , Mukherjee Tuhina , Song Linjie 
Published: July 2024

This article focuses on the existence and non-existence of solutions for the following system of local and nonlocal type − ∂ x x u + ( − Δ ) y s 1 u + u − u 2 s 1 − 1 = κ α h ( x , y ) u α − 1 v β in R 2 , − ∂ x x v + ( − Δ ) y s 2 v + v − v 2 s 2 − 1 = κ β h ( x , y ) u α v β − 1 in R 2 , u , v ⩾ 0 in R 2 , where s 1 , s 2 ∈ ( 0 , 1 ) , α, β > 1, α + β ⩽ min { 2 s 1 , 2 s 2 }, and 2 s i = 2 ( 1 + s i ) 1 − s i , i = 1 , 2. The existence of a ground state solution entirely depends on the behaviour of the parameter κ > 0 and on the function h. In this article, we prove that a ground state solution exists in the subcritical case if κ is large enough and h satisfies (H). Further, if κ becomes very small, then there is no solution to our system. The study of the critical case, i.e., s 1 = s 2 = s, α + β = 2 s , is more complex, and the solution exists only for large κ and radial h satisfying (H1). Finally, we establish a Pohozaev identity which enables us to prove the non-existence results under some smooth assumptions on h.
Protective effects of Ruscus extract in combination with ascorbic acid and hesperidine methylchalcone on increased leukocyte-endothelial interaction and macromolecular permeability induced by ischemia reperfusion injury
Authors: de Souza Maria das Graças C. , Cyrino Fatima Z.G.A. , Bouskela Eliete 
Published: July 2024

BACKGROUND: Despite the well-recognized effectiveness of Ruscus aculetus extract combined or not with ascorbic acid (AA) and hesperidine methyl chalcone (HMC) on ischemia reperfusion (I/R) injury protection, little is known about the contribution of each constituent for this effect. OBJECTIVE: To investigate the effects of AA and HMC combined or not with Ruscus extract on increased macromolecular permeability and leukocyte-endothelium interaction induced by I/R injury. METHODS: Hamsters were treated daily during two weeks with filtered water (placebo), AA (33, 100 and 300 mg/kg/day) and HMC (50, 150 and 450 mg/kg/day) combined or not with Ruscus extract (50, 150 and 450 mg/kg/day). On the day of experiment, the cheek pouch microcirculation underwent 30 min of ischemia, and the number of rolling and adherent leukocytes and leaky sites were evaluated before ischemia and during 45 min of reperfusion. RESULTS: Ruscus extract combined with AA and HMC ( Ruscus extract mixture) significantly prevented post-ischemic increase in leukocyte rolling and adhesion and macromolecular permeability compared to placebo and these effects were more prominent than AA and HMC alone on leukocyte adhesion and macromolecular leakage. CONCLUSION: Ruscus extract mixture were more effective than its isolated constituents in protect the hamster cheek pouch microcirculation against I/R injury.
The Case of the Cookie Jar: Differences in Typical Language Use in Dementia
Authors: Fromm Davida , Dalton Sarah Grace , Brick Alexander , Olaiya Gbenuola , Hill Sophia , Greenhouse Joel , MacWhinney Brian 
Published: July 2024

Background: Findings from language sample analyses can provide efficient and effective indicators of cognitive impairment in older adults. Objective: This study used newly automated core lexicon analyses of Cookie Theft picture descriptions to assess differences in typical use across three groups. Methods: Participants included adults without diagnosed cognitive impairments (Control), adults diagnosed with Alzheimer’s disease (ProbableAD), and adults diagnosed with mild cognitive impairment (MCI). Cookie Theft picture descriptions were transcribed and analyzed using CLAN. Results: Results showed that the ProbableAD group used significantly fewer core lexicon words overall than the MCI and Control groups. For core lexicon content words (nouns, verbs), however, both the MCI and ProbableAD groups produced significantly fewer words than the Control group. The groups did not differ in their use of core lexicon function words. The ProbableAD group was also slower to produce most of the core lexicon words than the MCI and Control groups. The MCI group was slower than the Control group for only two of the core lexicon content words. All groups mentioned a core lexicon word in the top left quadrant of the picture early in the description. The ProbableAD group was then significantly slower than the other groups to mention a core lexicon word in the other quadrants. Conclusions: This standard and simple-to-administer task reveals group differences in overall core lexicon scores and the amount of time until the speaker produces the key items. Clinicians and researchers can use these tools for both early assessment and measurement of change over time.
Screening Targets and Therapeutic Drugs for Alzheimer’s Disease Based on Deep Learning Model and Molecular Docking
Authors: Zhang Ya-Hong , Zhao Pu , Gao Hui-Ling , Zhong Man-Li , Li Jia-Yi 
Published: July 2024

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder caused by a complex interplay of various factors. However, a satisfactory cure for AD remains elusive. Pharmacological interventions based on drug targets are considered the most cost-effective therapeutic strategy. Therefore, it is paramount to search potential drug targets and drugs for AD. Objective: We aimed to provide novel targets and drugs for the treatment of AD employing transcriptomic data of AD and normal control brain tissues from a new perspective. Methods: Our study combined the use of a multi-layer perceptron (MLP) with differential expression analysis, variance assessment and molecular docking to screen targets and drugs for AD. Results: We identified the seven differentially expressed genes (DEGs) with the most significant variation (ANKRD39, CPLX1, FABP3, GABBR2, GNG3, PPM1E, and WDR49) in transcriptomic data from AD brain. A newly built MLP was used to confirm the association between the seven DEGs and AD, establishing these DEGs as potential drug targets. Drug databases and molecular docking results indicated that arbaclofen, baclofen, clozapine, arbaclofen placarbil, BML-259, BRD-K72883421, and YC-1 had high affinity for GABBR2, and FABP3 bound with oleic, palmitic, and stearic acids. Arbaclofen and YC-1 activated GABAB receptor through PI3K/AKT and PKA/CREB pathways, respectively, thereby promoting neuronal anti-apoptotic effect and inhibiting p-tau and Aβ formation. Conclusions: This study provided a new strategy for the identification of targets and drugs for the treatment of AD using deep learning. Seven therapeutic targets and ten drugs were selected by using this method, providing new insight for AD treatment.
Sensorimotor Impairment in Aging and Neurocognitive Disorders: Beat Synchronization and Adaptation to Tempo Changes
Authors: von Schnehen Andres , Hobeika Lise , Houot Marion , Recher Arnaud , Puisieux François , Huvent-Grelle Dominique , Samson Séverine 
Published: July 2024

Background: Understanding the nature and extent of sensorimotor decline in aging individuals and those with neurocognitive disorders (NCD), such as Alzheimer’s disease, is essential for designing effective music-based interventions. Our understanding of rhythmic functions remains incomplete, particularly in how aging and NCD affect sensorimotor synchronization and adaptation to tempo changes. Objective: This study aimed to investigate how aging and NCD severity impact tapping to metronomes and music, with and without tempo changes. Methods: Patients from a memory clinic participated in a tapping task, synchronizing with metronomic and musical sequences, some of which contained sudden tempo changes. After exclusions, 51 patients were included in the final analysis. Results: Participants’ Mini-Mental State Examination scores were associated with tapping consistency. Additionally, age negatively influenced consistency when synchronizing with a musical beat, whereas consistency remained stable across age when tapping with a metronome. Conclusions: The results indicate that the initial decline of attention and working memory with age may impact perception and synchronization to a musical beat, whereas progressive NCD-related cognitive decline results in more widespread sensorimotor decline, affecting tapping irrespective of audio type. These findings underline the importance of customizing rhythm-based interventions to the needs of older adults and individuals with NCD, taking into consideration their cognitive as well as their rhythmic aptitudes.
Unraveling the Threads: Sleep Difficulties, Neighborhood Physical Disorder, and Subjective Cognitive Decline in Older Americans
Authors: Esiaka Darlingtina , Odo Obinna , Luth Elizabeth 
Published: July 2024

Background: Research suggests that the neighborhood in which people live can be a risk or protective factor for various health outcomes, including cognitive decline to Alzheimer’s disease. Similar to the impact of neighborhood on health outcomes, sleep difficulties have been linked to cognitive function in older adults. However, few studies have examined how neighborhood physical disorders moderate the effects of sleep on subjective cognitive decline (SCD). Objective: The study examined the moderating effect of neighborhood factors on the relationship between sleep difficulties and SCD. Methods: Data were obtained from 2,494 respondents (1,065 males and 1,429 females) from Wave 11 of the National Health and Aging Trends (NHATS) data. Sleep difficulties were operationalized as the presence of difficulties in falling and staying asleep. Neighborhood physical disorder (e.g., vandalism, graffiti) was based on interviewer observations of respondents’ neighborhoods. SCD was operationalized as subjective reports of increasing or worse memory loss in the past 12 months and present memory rating. We utilized Linear regression to test neighborhood physical disorder as a moderator of the relationship between sleep difficulties and SCD. Results: We found a significant interaction between sleep difficulties and neighborhood physical disorder on SCD (β=0.046, p = 0.031, 95% CI[0.00,0.51], p < 0.001). Participants who reported higher average sleep difficulties and higher levels of neighborhood physical disorder were more likely to report SCD. Conclusions: Our findings add to inform future health interventions and policy recommendations that address modifiable sources of cognitive decline and risk of Alzheimer’s disease.
Understanding Racial Disparities in Dementia Prevalence Among Veterans
Authors: Arenson Melanie , Bahorik Amber , Xia Feng , Peltz Carrie , Cohen Beth , Yaffe Kristine 
Published: July 2024

Background: Black and Hispanic older adults have greater incidence of Alzheimer’s disease and related dementias relative to White adults, but factors underlying these disparities are not well understood, limiting the ability to address them. Objective: To determine the impact of demographics, cardiovascular disease (CVD) and risk factors, social determinants of health (SDOH), and neuropsychiatric risk factors on racial/ethnic disparities in dementia risk among Veterans. Methods: We examined a random sample of 1,579,919 older Veterans (age ≥55) without dementia who received care from the VHA from October 1, 1999 to September 30, 2021. All variables were extracted from national VHA data. We used Cox proportional hazard regression models to examine change in variance in risk of dementia across racial/ethnic groups. Results: During follow up (mean 11.1 years), 13% of Veterans developed dementia. Relative to White Veterans, the adjusted hazard ratios (AHRs) for developing dementia in sex-adjusted models with age as timescale were 1.65 (95% CI, 1.63–1.67) for Black Veterans and 1.50 (95% CI, 1.44–1.56) for Hispanic Veterans. In the model examining CVD and risk factors, AHRs were 1.53 (95% CI, 1.50–1.55) for Black Veterans and 1.38 (95% CI, 1.33–1.44) for Hispanic Veterans. In the model examining SDOH, AHRs were 1.46 (95% CI, 1.43–1.49) for Black Veterans and 1.34 (95% CI, 1.29–1.40) for Hispanic Veterans. Conclusions: SDOH and CVD and risk factors accounted for the greatest amount of variance in racial/ethnic disparities in dementia risk. Cardiovascular disease and SDOH are strong possible targets for interventions designed to reduce these disparities.
Association of Anxiety and Unspecified Emotional Distress Obtained from a Medical Records Linkage System with Incident Cognitive Outcomes in a Population-Based Setting
Authors: Syrjanen Jeremy A. , Krell-Roesch Janina , Kremers Walter K. , Fields Julie A. , Scharf Eugene L. , Knopman David S. , Petersen Ronald C. , Vassilaki Maria , Geda Yonas E. 
Published: July 2024

Background: Studies that assess cognition prospectively and study in detail anxiety history in the participants’ medical records within the context of brain aging and Alzheimer’s disease are limited. Objective: To examine the associations of anxiety and unspecified emotional distress (UED) acquired throughout a person’s life with prospectively collected cognitive outcomes. Methods: Mayo Clinic Study of Aging participants who were cognitively unimpaired at baseline were included. Anxiety and UED data were abstracted from the medical record using the Rochester Epidemiology Project (REP) resources and were run separately as predictors in our models. The data were analyzed using Cox proportional hazards models for the outcomes of incident mild cognitive impairment (MCI) and dementia and using linear mixed effects models for the outcomes of global and domain specific cognitive z-scores and included key covariates. Results: The study sample ( n = 1,808) had a mean (standard deviation) age of 74.5 (7.3) years and 51.4% were male. Anxiety was associated with increased risk of MCI and dementia and was associated with lower baseline cognitive z-scores and accelerated decline over time in the global, memory, and attention domains. UED was associated with faster decline in all domains except visuospatial but did not show evidence of association with incident cognitive outcomes. These results varied by medication use and timing of anxiety. Conclusions: Anxiety and UED both showed inverse associations with cognition. Utilization of anxiety and UED data from across the life course, as available, from the REP system adds robustness to our results.
Undetected Association Between Fatty Acids and Dementia with Lewy Bodies: A Bidirectional Two-Sample Mendelian Randomization Study
Authors: Zhai Weijie , Zhao Anguo , Wei Chunxiao , Xu Yanjiao , Cui Xinran , Zhang Yan , Meng Lingjie , Sun Li 
Published: July 2024

Background: Although observational studies indicated connections between fatty acids (FAs) and Alzheimer’s disease and dementia, uncertainty persists regarding how these relationships extend to dementia with Lewy bodies (DLB). Objective: To explore the potential causal relationships between FAs and the development of DLB, thus clarifying these associations using genetic instruments to infer causality. Methods: We applied a two-sample Mendelian randomization (MR) and multivariable Mendelian randomization (MVMR) approach. Genetic data were obtained from a DLB cohort, comprising 2,591 cases and 4,027 controls of European descent. Eight FAs, including linoleic acid, docosahexaenoic acid, monounsaturated fatty acid, omega-3 fatty acid, omega-6 fatty acid, polyunsaturated fatty acid, saturated fatty acid, and total fatty acid, were procured from a comprehensive GWAS of metabolic biomarkers of UK Biobank, conducted by Nightingale Health in 2020 (met-d), involving 114,999 individuals. Our analysis included inverse-variance weighted, MR-Egger, weighted-median, simple mode, and weighted-mode MR estimates. Cochran’s Q-statistics, MR-PRESSO, and MR-Egger intercept test were used to quantify the heterogeneity and horizontal pleiotropy of instrumental variables. Results: Only linoleic acid showed a significant genetic association with the risk of developing DLB in the univariate MR. The odds ratio for linoleic acid was 1.337 with a 95% confidence interval of 1.019–1.756 (pIVW = 0.036). Results from the MVMR showed that no FAs were associated with the incidence of DLB. Conclusions: The results did not support the hypothesis that FAs could reduce the risk of developing DLB. However, elucidating the relationship between FAs and DLB risk holds potential implications for informing dietary recommendations and therapeutic approaches in DLB.