bluuebunny/crossref_metadata_2025_split huggingface dataset:
Suitcases and the Poetics of Oddities: Writing History from Disorderly Archives
Authors: Bernault Florence 
Published: May 2015

AbstractI argue here against two things: fetishizing the power and wholesomeness of colonial archives, and equating the scarcity of post-1960 repositories with new difficulties to write the past of Africa. Instead, I suggest the productive power of odd findings, and the necessity for historians to trust the energy of heterodox pieces to create original and meaningful historical narratives.
Anxiety and styles of coping with occupational stress resulting from work with ‘dangerous’ prisoners in prison service officers
Authors: Tsirigotis Konstantinos , Gruszczyński Wojciech , Pęczkowski Sebastian 
Published: May 2015

ObjectivePrisoners categorised as ‘dangerous’ are a category of prisoners that require and/or force into using special measures of caution, protection and security. The aim of the study was to examine the intensity of anxiety (as a state and as a trait) experienced by officers working with ‘dangerous’ prisoners and styles of coping with stress they adopt.MethodsA total of 40 officers working with ‘dangerous’ prisoners (the study group, SG) and 60 officers of the security department not working with ‘dangerous’ prisoners (the reference group, RG) were studied. The intensity of anxiety was assessed applying the Polish version of ‘State-Trait Anxiety Inventory’ (STAI); styles of coping with stress were explored employing the Polish version of ‘Coping Inventory for Stressful Situations’ (CISS) and the author’s own questionnaire. Data were analysed using the mean, standard deviation, difference testing (the Mann–Whitney U test), correlation–regression procedure (Kendall’s tau, τ correlation coefficient and forward stepwise multiple regression).ResultsOfficers in the SG faced verbal and physical aggression; nevertheless, scores of officers in both the groups were within the interval of mean scores for all the studied STAI and CISS variables. Officers in the SG achieved significantly higher scores on the state-anxiety scale and the Emotion-Oriented Style (EOS), and lower scores on the Task-Oriented Style (TOS) and Social Diversion (SD). The correlation-regression procedure indicated that there were relationships between anxiety and styles of coping with stress but they differed slightly between the groups.ConclusionsOfficers in the SG feel state anxiety stronger and display a stronger preference for the EOS than officers in the RG. Officers in the RG more strongly prefer the TOS and SD. State anxiety is a variable negatively explaining the TOS in the SG, whereas anxiety as a trait is a variable explaining the EOS in both the groups. The coping styles of warders dealing with dangerous prisoners are different and may need specific psychological counselling and training programmes.
Distribution and conservation status of Shortridge's capped langurs Trachypithecus shortridgei in China
Authors: Cui Liang-Wei , Li Ying-Chun , Ma Chi , Scott Matthew B. , Li Jin-Fa , He Xiao-Yang , Li Dong-Hui , Sun Jun , Sun Wen-Mo , Xiao Wen 
Published: May 2015

AbstractWe conducted community interviews and field surveys to determine the distribution and population of the Endangered Shortridge's capped langur Trachypithecus shortridgei, and the threats to the species, in the Dulong and Nu River valleys of north-western Yunnan Province, China. We found that c. 19 groups of T. shortridgei reside in the Dulong valley, mostly located in the southern portion of the valley. According to interview and observational records in the Gaoligong Mountains to the west of the Nu River, 12 individuals and no groups were observed. Family groups consist of one adult male, 2–3 adult females and up to five young. We estimate the population of T. shortridgei in China to be c. 250–370 individuals. Threats to the species include habitat loss and poaching. We suggest several measures to conserve T. shortridgei, such as a review of the Gaoligong National Nature Reserve management strategy, and increasing engagement, education, inclusion of local people in forest management, and the consistency of enforcement.
Cognitive–behavioural therapy in medication-treated adults with attention-deficit/hyperactivity disorder and co-morbid psychopathology: a randomized controlled trial using multi-level analysis
Authors: Young S. , Khondoker M. , Emilsson B. , Sigurdsson J. F. , Philipp-Wiegmann F. , Baldursson G. , Olafsdottir H. , Gudjonsson G. 
Published: May 2015

BackgroundAttention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by high rates of co-morbid psychopathology. Randomized controlled trials of multimodal interventions, combining pharmacological and psychological treatments, have shown a robust treatment effect for ADHD symptoms but outcomes for co-morbid symptoms have been mixed. This may be accounted for by the type of intervention selected and/or by methodological problems including lack of follow-up and low power. The current study addressed these limitations in a parallel-group randomized controlled trial conducted in Iceland.MethodA total of 95 adult ADHD patients who were already being treated with medication (MED) were randomly assigned to receive treatment as usual (TAU/MED) or 15 sessions of cognitive–behavioural therapy (CBT/MED) using theR&R2ADHDintervention which employs both group and individual modalities. Primary measures of ADHD symptoms and severity of illness, and secondary measures of anxiety, depression and quality of life were given at baseline, end of treatment and 3-month follow-up. Primary outcomes were rated by clinicians blind to treatment condition assignment.ResultsCBT/MED showed overall (combined outcome at end of treatment and 3-month follow-up) significantly greater reduction in primary outcomes for clinician-rated and self-rated ADHD symptoms. Treatment effect of primary outcomes was maintained at follow-up, which suggests robust and lasting findings. In contrast to the primary outcomes, the secondary outcomes showed significant improvement over time.ConclusionsThe study provides evidence for the effectiveness ofR&R2ADHDand demonstrates that there are differential effects over time for ADHD symptomsversusco-morbid problems, the latter taking longer to show positive effects.
Effects of motion type and modality on word learning in English
Authors: EMERSON SAMANTHA N. , ÖZÇALIŞKAN ŞEYDA , FRISHKOFF GWEN A. 
Published: May 2015

ABSTRACTLanguages show typological variation in the expression of manner versus path of motion. However, studies examining the effects of these differences on cognitive representations of motion have led to inconclusive results. To elucidate this prior work, the present study examines word-learning outcomes for adult English speakers who were exposed to new motion words paired with animations that depict either different manners or different paths of motion. The results indicate better learning of words that represent path rather than manner of motion. The outcomes were similar for training with and without accompanying gestures. These findings support the centrality of path in the cognitive representation of motion events and may have important implications for language typology and understanding interactions between language and cognition.
Number fields without small generators
Authors: VAALER JEFFREY D. , WIDMER MARTIN 
Published: May 2015

AbstractLet D > 1 be an integer, and let b = b(D) > 1 be its smallest divisor. We show that there are infinitely many number fields of degree D whose primitive elements all have relatively large height in terms of b, D and the discriminant of the number field. This provides a negative answer to a question of W. Ruppert from 1998 in the case when D is composite. Conditional on a very weak form of a folk conjecture about the distribution of number fields, we negatively answer Ruppert's question for all D > 3.
Characterization of Darai Limestone Composition and Porosity Using Data-Constrained Modeling and Comparison with Xenon K-Edge Subtraction Imaging
Authors: Mayo Sheridan C. , Yang Sam Y.S. , Pervukhina Marina , Clennell Michael B. , Esteban Lionel , Irvine Sarah C. , Siu Karen K. , Maksimenko Anton S. , Tulloh Andrew M. 
Published: May 2015

AbstractData-constrained modeling is a method that enables three-dimensional distribution of mineral phases and porosity in a sample to be modeled based on micro-computed tomography scans acquired at different X-ray energies. Here we describe an alternative method for measuring porosity, synchrotron K-edge subtraction using xenon gas as a contrast agent. Results from both methods applied to the same Darai limestone sample are compared. Reasonable agreement between the two methods and with other porosity measurements is obtained. The possibility of a combination of data-constrained modeling and K-edge subtraction methods for more accurate sample characterization is discussed.
Morphometry of volcanic cones on Mars in perspective of Astrobiological Research
Authors: Gilichinsky Michael , Demidov Nikita , Rivkina Elizaveta 
Published: May 2015

AbstractThe permanently frozen volcanic sediment is one of the most promising geological objects for searching life on Mars. On Earth, volcanic intrusions into permafrost result in formation of the unique microbial communities. We propose several terrestrial analogues of Martian polar volcanoes, such as the permanently frozen volcanic sediments on the Kamchatka peninsula and in Antarctica. The present study shows applicability of the morphometric analysis for demonstration of the morphological similarity between the terrestrial and Martian cinder cones. In the present work, the morphometric analysis of young Martian landforms is based on the assumption that the conical structures identified on digital terrain model (DTM) are volcanic cinder cones. Morphometric analysis of the studied cones showed a range of degradation. The extent of degradation may be an indicator of age based on comparison with volcanic cinder cones on Earth. A morphometric analysis of potentially young volcanic cones in the North Polar Region of Mars was performed to estimate their relative age. The 14 potential cinder cones were identified using the DTM provided by Mars Express High Resolution Stereo Camera (HRSC), allowing for the basic morphometric calculations. The majority of the cinder cones are localized in the Chasma Boreale region within the area 79°–81°N and 261°–295°E. The calculated morphometric parameters showed that the cone average steepness varied from 3.4° to 11.8°, cone height-to-width ratio varied from 0.025 to 0.12, and the ratio between surface and basal area of the cone varied from 1.005 to 1.131. The studied cinder cones were classified with respect to the morphometric ratios assuming that larger values correspond to the younger structures. Employing the terrestrial analogy of morphometric ratios as a proxy for relative geological age, we suggest that existing microorganisms may be found in permafrost of young Martian cinder cones.
A novel antibody–drug conjugate targeting SAIL for the treatment of hematologic malignancies
Authors: Kim S Y , Theunissen J-W , Balibalos J , Liao-Chan S , Babcock M C , Wong T , Cairns B , Gonzalez D , van der Horst E H , Perez M , Levashova Z , Chinn L , D‘Alessio J A , Flory M , Bermudez A , Jackson D Y , Ha E , Monteon J , Bruhns M F , Chen G , Migone T-S 
Published: May 2015

AbstractAlthough several new therapeutic approaches have improved outcomes in the treatment of hematologic malignancies, unmet need persists in acute myeloid leukemia (AML), multiple myeloma (MM) and non-Hodgkin’s lymphoma. Here we describe the proteomic identification of a novel cancer target, SAIL (Surface Antigen In Leukemia), whose expression is observed in AML, MM, chronic lymphocytic leukemia (CLL), diffuse large B-cell lymphoma (DLBCL) and follicular lymphoma (FL). While SAIL is widely expressed in CLL, AML, MM, DLBCL and FL patient samples, expression in cancer cell lines is mostly limited to cells of AML origin. We evaluated the antitumor activity of anti-SAIL monoclonal antibodies, 7-1C and 67-7A, conjugated to monomethyl auristatin F. Following internalization, anti-SAIL antibody–drug conjugates (ADCs) exhibited subnanomolar IC50 values against AML cell lines in vitro. In pharmacology studies employing AML cell line xenografts, anti-SAIL ADCs resulted in significant tumor growth inhibition. The restricted expression profile of this target in normal tissues, the high prevalence in different types of hematologic cancers and the observed preclinical activity support the clinical development of SAIL-targeted ADCs.
Volatile affairs in microbial interactions
Authors: Schmidt Ruth , Cordovez Viviane , de Boer Wietse , Raaijmakers Jos , Garbeva Paolina 
Published: May 2015

Abstract
Microorganisms are important factors in shaping our environment. One key characteristic that has been neglected for a long time is the ability of microorganisms to release chemically diverse volatile compounds. At present, it is clear that the blend of volatiles released by microorganisms can be very complex and often includes many unknown compounds for which the chemical structures remain to be elucidated. The biggest challenge now is to unravel the biological and ecological functions of these microbial volatiles. There is increasing evidence that microbial volatiles can act as infochemicals in interactions among microbes and between microbes and their eukaryotic hosts. Here, we review and discuss recent advances in understanding the natural roles of volatiles in microbe–microbe interactions. Specific emphasis will be given to the antimicrobial activities of microbial volatiles and their effects on bacterial quorum sensing, motility, gene expression and antibiotic resistance.
Marked seasonal variation in the wild mouse gut microbiota
Authors: Maurice Corinne F , Knowles Sarah C L , Ladau Joshua , Pollard Katherine S , Fenton Andy , Pedersen Amy B , Turnbaugh Peter J 
Published: May 2015

Abstract
Recent studies have provided an unprecedented view of the microbial communities colonizing captive mice; yet the host and environmental factors that shape the rodent gut microbiota in their natural habitat remain largely unexplored. Here, we present results from a 2-year 16 S ribosomal RNA gene sequencing-based survey of wild wood mice (Apodemus sylvaticus) in two nearby woodlands. Similar to other mammals, wild mice were colonized by 10 bacterial phyla and dominated by the Firmicutes, Bacteroidetes and Proteobacteria. Within the Firmicutes, the Lactobacillus genus was most abundant. Putative bacterial pathogens were widespread and often abundant members of the wild mouse gut microbiota. Among a suite of extrinsic (environmental) and intrinsic (host-related) factors examined, seasonal changes dominated in driving qualitative and quantitative differences in the gut microbiota. In both years examined, we observed a strong seasonal shift in gut microbial community structure, potentially due to the transition from an insect- to a seed-based diet. This involved decreased levels of Lactobacillus, and increased levels of Alistipes (Bacteroidetes phylum) and Helicobacter. We also detected more subtle but statistically significant associations between the gut microbiota and biogeography, sex, reproductive status and co-colonization with enteric nematodes. These results suggest that environmental factors have a major role in shaping temporal variations in microbial community structure within natural populations.
Evolutionary transition in symbiotic syndromes enabled diversification of phytophagous insects on an imbalanced diet
Authors: Sudakaran Sailendharan , Retz Franziska , Kikuchi Yoshitomo , Kost Christian , Kaltenpoth Martin 
Published: May 2015

Abstract
Evolutionary adaptations for the exploitation of nutritionally challenging or toxic host plants represent a major force driving the diversification of phytophagous insects. Although symbiotic bacteria are known to have essential nutritional roles for insects, examples of radiations into novel ecological niches following the acquisition of specific symbionts remain scarce. Here we characterized the microbiota across bugs of the family Pyrrhocoridae and investigated whether the acquisition of vitamin-supplementing symbionts enabled the hosts to diversify into the nutritionally imbalanced and chemically well-defended seeds of Malvales plants as a food source. Our results indicate that vitamin-provisioning Actinobacteria (Coriobacterium and Gordonibacter), as well as Firmicutes (Clostridium) and Proteobacteria (Klebsiella) are widespread across Pyrrhocoridae, but absent from the sister family Largidae and other outgroup taxa. Despite the consistent association with a specific microbiota, the Pyrrhocoridae phylogeny is neither congruent with a dendrogram based on the hosts’ microbial community profiles nor phylogenies of individual symbiont strains, indicating frequent horizontal exchange of symbiotic partners. Phylogenetic dating analyses based on the fossil record reveal an origin of the Pyrrhocoridae core microbiota in the late Cretaceous (81.2–86.5 million years ago), following the transition from crypt-associated beta-proteobacterial symbionts to an anaerobic community localized in the M3 region of the midgut. The change in symbiotic syndromes (that is, symbiont identity and localization) and the acquisition of the pyrrhocorid core microbiota followed the evolution of their preferred host plants (Malvales), suggesting that the symbionts facilitated their hosts’ adaptation to this imbalanced nutritional resource and enabled the subsequent diversification in a competition-poor ecological niche.
The dynamics of methylammonium ions in hybrid organic–inorganic perovskite solar cells
Authors: Leguy Aurelien M. A. , Frost Jarvist Moore , McMahon Andrew P. , Sakai Victoria Garcia , Kockelmann W. , Law ChunHung , Li Xiaoe , Foglia Fabrizia , Walsh Aron , O’Regan Brian C. , Nelson Jenny , Cabral João T. , Barnes Piers R. F. 
Published: May 2015

AbstractMethylammonium lead iodide perovskite can make high-efficiency solar cells, which also show an unexplained photocurrent hysteresis dependent on the device-poling history. Here we report quasielastic neutron scattering measurements showing that dipolar CH3NH3+ ions reorientate between the faces, corners or edges of the pseudo-cubic lattice cages in CH3NH3PbI3 crystals with a room temperature residence time of ∼14 ps. Free rotation, π-flips and ionic diffusion are ruled out within a 1–200-ps time window. Monte Carlo simulations of interacting CH3NH3+ dipoles realigning within a 3D lattice suggest that the scattering measurements may be explained by the stabilization of CH3NH3+ in either antiferroelectric or ferroelectric domains. Collective realignment of CH3NH3+ to screen a device’s built-in potential could reduce photovoltaic performance. However, we estimate the timescale for a domain wall to traverse a typical device to be ∼0.1–1 ms, faster than most observed hysteresis.
Contrasting expression patterns of coding and noncoding parts of the human genome upon oxidative stress
Authors: Giannakakis Antonis , Zhang Jingxian , Jenjaroenpun Piroon , Nama Srikanth , Zainolabidin Norliyana , Aau Mei Yee , Yarmishyn Aliaksandr A. , Vaz Candida , Ivshina Anna V. , Grinchuk Oleg V. , Voorhoeve Mathijs , Vardy Leah A. , Sampath Prabha , Kuznetsov Vladimir A. , Kurochkin Igor V. , Guccione Ernesto 
Published: May 2015

AbstractOxidative stress (OS) is caused by an imbalance between pro- and anti-oxidant reactions leading to accumulation of reactive oxygen species within cells. We here investigate the effect of OS on the transcriptome of human fibroblasts. OS causes a rapid and transient global induction of transcription characterized by pausing of RNA polymerase II (PolII) in both directions, at specific promoters, within 30 minutes of the OS response. In contrast to protein-coding genes, which are commonly down-regulated, this novel divergent, PolII pausing-phenomenon leads to the generation of thousands of long noncoding RNAs (lncRNAs) with promoter-associated antisense lncRNAs transcripts (si-paancRNAs) representing the major group of stress-induced transcripts. OS causes transient dynamics of si-lncRNAs in nucleus and cytosol, leading to their accumulation at polysomes, in contrast to mRNAs, which get depleted from polysomes. We propose that si-lncRNAs represent a novel component of the transcriptional stress that is known to determine the outcome of immediate-early and later cellular stress responses and we provide insights on the fate of those novel mature lncRNA transcripts by showing that their association with polysomal complexes is significantly increased in OS.
Quantum Simulation of Dissipative Processes without Reservoir Engineering
Authors: Di Candia R. , Pedernales J. S. , del Campo A. , Solano E. , Casanova J. 
Published: May 2015

AbstractWe present a quantum algorithm to simulate general finite dimensional Lindblad master equations without the requirement of engineering the system-environment interactions. The proposed method is able to simulate both Markovian and non-Markovian quantum dynamics. It consists in the quantum computation of the dissipative corrections to the unitary evolution of the system of interest, via the reconstruction of the response functions associated with the Lindblad operators. Our approach is equally applicable to dynamics generated by effectively non-Hermitian Hamiltonians. We confirm the quality of our method providing specific error bounds that quantify its accuracy.
A bioinspired peptide scaffold with high antibiotic activity and low in vivo toxicity
Authors: Rabanal Francesc , Grau-Campistany Ariadna , Vila-Farrés Xavier , Gonzalez-Linares Javier , Borràs Miquel , Vila Jordi , Manresa Angeles , Cajal Yolanda 
Published: May 2015

AbstractBacterial resistance to almost all available antibiotics is an important public health issue. A major goal in antimicrobial drug discovery is the generation of new chemicals capable of killing pathogens with high selectivity, particularly multi-drug-resistant ones. Here we report the design, preparation and activity of new compounds based on a tunable, chemically accessible and upscalable lipopeptide scaffold amenable to suitable hit-to-lead development. Such compounds could become therapeutic candidates and future antibiotics available on the market. The compounds are cyclic, contain two D-amino acids for in vivo stability and their structures are reminiscent of other cyclic disulfide-containing peptides available on the market. The optimized compounds prove to be highly active against clinically relevant Gram-negative and Gram-positive bacteria. In vitro and in vivo tests show the low toxicity of the compounds. Their antimicrobial activity against resistant and multidrug-resistant bacteria is at the membrane level, although other targets may also be involved depending on the bacterial strain.
Quenched pinning and collective dislocation dynamics
Authors: Ovaska Markus , Laurson Lasse , Alava Mikko J. 
Published: May 2015

AbstractSeveral experiments show that crystalline solids deform in a bursty and intermittent fashion. Power-law distributed strain bursts in compression experiments of micron-sized samples and acoustic emission energies from larger-scale specimens, are the key signatures of the underlying critical-like collective dislocation dynamics - a phenomenon that has also been seen in discrete dislocation dynamics (DDD) simulations. Here we show, by performing large-scale two-dimensional DDD simulations, that the character of the dislocation avalanche dynamics changes upon addition of sufficiently strong randomly distributed quenched pinning centres, present e.g. in many alloys as immobile solute atoms. For intermediate pinning strength, our results adhere to the scaling picture of depinning transitions, in contrast to pure systems where dislocation jamming dominates the avalanche dynamics. Still stronger disorder quenches the critical behaviour entirely.