bluuebunny/crossref_metadata_2025_split huggingface dataset:
Organizational attachment in hybrids: identification, commitment and exit/voice/loyalty
Authors: Foreman Peter 
Published: August 2024

Purpose
This study aims to examine member attachment in hybrid identity organizations (HIOs), assessing the distinct effects of identification with respect to two elements (normative and utilitarian) of a hybrid’s identity. Specifically, the author explored how such dual identifications influence commitment and exit/voice/loyalty.

Design/methodology/approach
To distinguish the effects of the two identities, the author used the mechanism of identity congruence – the gap between identity perceptions and expectations – as an analog of identification. The models of identity gap, commitment and exit/voice/loyalty were examined via a survey of agricultural cooperative members.

Findings
Both the social and economic forms of identity gap were significantly related to commitment and exit/voice/loyalty. In addition, commitment mediated the relationship between identity gap and exit/voice/loyalty.

Research limitations/implications
The results demonstrate the distinctive effects of the dual identities and reinforce the importance of delineating such differences when examining identification in hybrid organizations.

Practical implications
Managers should recognize the duality inherent in hybrid organizational identification and understand the potential for different outcomes stemming from the separate identities.

Originality/value
This study represents the first quantitative examination of an integrated model of dual identification and commitment in HIOs. It is also unique in exploring the exit/voice/loyalty framework as a consequent of identification.
The impact of social capital on the intention of Moroccan university students to engage in social entrepreneurship
Authors: Mgueraman Adil , EL Abboubi Manal 
Published: August 2024

Purpose
This research seeks to analyse the process by which undergraduate students make decisions on social entrepreneurship intention (SEI) using the theory of planned behaviour (TPB) model, as well as to comprehend the influence of social capital (SC) on their SEI.

Design/methodology/approach
The sample was obtained from the Faculty of Legal, Economic and Social Sciences of Agdal in Rabat, consisting of third-year students enrolled in a bachelor’s or master’s degree programme. The study involved a total of 300 pupils. The authors used the multivariate analytic method known as partial least squares (PLS) to investigate the correlation between different components of our theoretical framework.

Findings
SC has demonstrated indirect influences on the development of intentions in the field of social entrepreneurship (SE). The perceived knowledge of the support network has a substantial impact on behavioural control and subjective norms, but it does not influence attitudes. In contrast, the perceived support from the friends and family network has a substantial impact on all three components of the model.

Research limitations/implications
Despite the study’s extensive coverage of several ideas and their consequences in both the theoretical and practical realms, it is important to acknowledge its inherent limitations. The cross-sectional design and use of a student sample may be perceived as restricting considerations.

Originality/value
This research provides valuable insights that support the investments in education, resources and human endeavours made by governmental entities, universities and the private sector. It also supports the initiatives undertaken by management and business schools, as well as trade associations. When individuals establish an intention to engage in SE, whether they act on it immediately or later on or whether they never act on it at all, there is a good signal that mentorship programmes and training in SE have an influence on the process of transitioning towards taking action.
Economic evaluation of alternative urban park designs that conserve irrigation water
Authors: Doll Claire A. , Pannell David J. , Burton Michael P. 
Published: August 2024

AbstractIncreasing the area of drought‐tolerant native vegetation in urban parks is a potential strategy to adapt to growing water scarcity under climate change. With a case study in Perth, Australia, we undertake benefit–cost analyses to understand the potential impacts of modifying urban park landscape designs away from conventions dominated by watered grass towards alternatives with more native vegetation. Considering the costs of establishing and maintaining alternative designs alone, we find that local governments can save money by reducing the extent of watered grass cover in parks. Incorporating nonmarket benefits into the analyses provides evidence of positive community net benefits from making changes to conventional park designs. We show that an alternative park design featuring a mix of 60% native vegetation and 40% watered grass delivers the highest net benefits for both new park development and retrofits to existing parks. These findings suggest it is time to rethink urban park design norms in Australia to better align landscaping choices with community preferences under a changing climate.
Unravelling the novel sex determination genotype with ‘ZY’ and a distinctive 2.15–2.95 Mb inversion among poplar species through haplotype‐resolved genome assembly and comparative genomics analysis
Authors: Li Juan , Chen Tingting , Gao Kai , Xue Yinxuan , Wu Ruqian , Guo Bin , Chen Zhong , Li Shanwen , Zhang Ren‐Gang , Jia Kai‐Hua , Mao Jian‐Feng , An Xinmin 
Published: August 2024

AbstractPopulus tomentosa, an indigenous tree species, is widely distributed and cultivated over 1,000,000 km2 in China, contributing significantly to forest production, ecological conservation and urban–rural greening. Although a reference genome is available for P. tomentosa, the intricate interspecific hybrid origins, chromosome structural variations (SVs) and sex determination mechanisms remain confusion and unclear due to its broad and even overlapping geographical distribution, extensive morphological variations and cross infiltration among white poplar species. We conducted a haplotype‐resolved de novo assembly of P. tomentosa elite individual GM107, which comprises subgenomes a and b with a total genome size of 714.9 Mb. We then analysed the formation of hybrid species and the phylogenetic evolution and sex differentiation across the entire genus. Phylogenomic analyses suggested that GM107 likely originated from a hybridisation event between P. alba (♀) and P. davidiana (♂) which diverged at approximately 3.8 Mya. A total of 1551 chromosome SVs were identified between the two subgenomes. More noteworthily, a distinctive inversion structure spanning 2.15–2.95 Mb was unveiled among Populus, Tacamahaca, Turaga, Aigeiros poplar species and Salix, highlighting a unique evolutionary feature. Intriguingly, a novel sex genotype of the ZY type, which represents a crossover between XY and ZW systems, was identified and confirmed through both natural and artificial hybrids populations. These novel insights offer significant theoretical value for the study of the species' evolutionary origins and serve as a valuable resource for ecological genetics and forest biotechnology.
METTL3/IGF2BP1 influences the development of non‐small‐cell lung cancer by mediating m6A methylation modification of TRPV1
Authors: Bai Wenjie , Xiao Gang , Xie Guijing , Chen Zhibo , Xu Xie , Zeng Jie , Xie Jianjiang 
Published: August 2024

AbstractBackgroundMethyltransferase 3 (METTL3) accelerates N6‐methyladenosine (m6A) modifications and affects cancer progression, including non‐small‐cell lung cancer (NSCLC). In this study, we aimed to explore the regulatory mechanisms of METTL3 underling NSCLC.MethodsImmunohistochemical assay, quantitative real‐time polymerase chain reaction (qRT‐PCR) assay, and western blot assay were conducted for gene expression. MTT assay and colony formation assay were performed to explore cell proliferation capacity. Cell apoptosis and THP‐1 cell polarization were estimated by flow cytometry analysis. Cell migration and invasion capacities were evaluated by transwell assay. Methylated RNA immunoprecipitation assay, dual‐luciferase reporter assay, actinomycin D treatment and RIP assay were performed to analyze the relationships of METTL3, insulin‐like growth factor 2 mRNA binding protein 1 (IGF2BP1), and transient receptor potential cation channel subfamily V member 1 (TRPV1). The functions of METTL3 and TRPV1 in vivo were investigated through establishing the murine xenograft model.ResultsTRPV1 expression was upregulated in NSCLC and related poor prognosis. TRPV1 silencing inhibited NSCLC cell growth and metastasis, induced NSCLC cell apoptosis, and repressed M2 macrophage polarization. The results showed that METTL3 and IGF2BP1 could regulate TRPV1 expression through m6A methylation modification. Moreover, METTL3 deficiency inhibited NSCLC cell growth, metastasis, and M2 macrophage polarization and facilitated NSCLC cell apoptosis, while TRPV1 overexpression restored the impacts. In addition, METTL3 knockdown restrained tumor growth in vivo via regulating TRPV1 expression.ConclusionMETTL3 bound to IGF2BP1 and enhanced IGF2BP1's m6A recognition of TRPV1 mRNA, thereby promoting NSCLC cell growth and metastasis, and inhibiting M2 macrophage polarization.
Clinical significance of chronic pulmonary aspergillosis in lung cancer patients undergoing anticancer drug therapy
Authors: Morimoto Kenji , Hamashima Ryosuke , Yamada Tadaaki , Yokoyama Toshihide , Kobayashi Takehiko , Tsuyuguchi Kazunari , Kanematsu Takanori , Tamiya Nobuyo , Tsuji Taisuke , Nakamura Ryota , Katayama Yuki , Nishioka Naoya , Iwasaku Masahiro , Tokuda Shinsaku , Takayama Koichi 
Published: August 2024

AbstractBackgroundAdvances in anticancer drugs for lung cancer (LC) have improved the prognosis of LC. Chronic pulmonary aspergillosis (CPA) is a progressive and often exacerbating respiratory disease with a poor prognosis. To date, the prognosis of LC complicated by CPA has not been elucidated. This study investigated the clinical implications of concomitant CPA in patients with LC undergoing anticancer drug treatment.MethodsBetween January 2010 and May 2020, we consecutively enrolled patients with LC complicated with CPA at five different institutions in Japan. We analyzed patients with LC complicated by CPA who received anticancer drug treatment.ResultsA total of 10 patients with LC complicated by CPA received anticancer drug treatment. The median overall survival (OS) was 14.57 months (95% confidence interval [CI]: 5.37–21.67). The cause of death in all patients was LC. Six of the seven patients with LC did not show worsening pulmonary aspergillosis lesions during the anticancer drug treatment. Although two patients discontinued anticancer drug treatment due to pneumonitis, CPA complications did not interfere with the continuation of anticancer drug treatment. In univariate analyses, squamous histology (p = 0.01) and body mass index (<18.5 kg/m2) (p = 0.0008) were significantly associated with poorer OS.ConclusionsThis study demonstrated that the cause of death in LC patients with concomitant CPA who received anticancer drug treatments and effective antifungal treatment was LC progression. Further large‐scale studies are needed to identify the effect of CPA in patients with LC.
Retro‐age: A unique epigenetic biomarker of aging captured by DNA methylation states of retroelements
Authors: Ndhlovu Lishomwa C. , Bendall Matthew L. , Dwaraka Varun , Pang Alina P. S. , Dopkins Nicholas , Carreras Natalia , Smith Ryan , Nixon Douglas F. , Corley Michael J. 
Published: August 2024

AbstractReactivation of retroelements in the human genome has been linked to aging. However, whether the epigenetic state of specific retroelements can predict chronological age remains unknown. We provide evidence that locus‐specific retroelement DNA methylation can be used to create retroelement‐based epigenetic clocks that accurately measure chronological age in the immune system, across human tissues, and pan‐mammalian species. We also developed a highly accurate retroelement epigenetic clock compatible with EPICv.2.0 data that was constructed from CpGs that did not overlap with existing first‐ and second‐generation epigenetic clocks, suggesting a unique signal for epigenetic clocks not previously captured. We found retroelement‐based epigenetic clocks were reversed during transient epigenetic reprogramming, accelerated in people living with HIV‐1, and responsive to antiretroviral therapy. Our findings highlight the utility of retroelement‐based biomarkers of aging and support a renewed emphasis on the role of retroelements in geroscience.
Non‐selective beta‐blocker is associated with reduced mortality in critically ill patients with cirrhosis: A real‐world study
Authors: Kumar Rahul , Lin Su , Mehta Gautam , Mesquita Monica D. , Calvao Joana A. F. , Sheikh M. Faisal , Agarwal Banwari , Mookerjee R. P. , Jalan Rajiv 
Published: August 2024

SummaryBackgroundApart from direct portal pressure reduction, non‐selective beta‐blockers (NSBB) modulate inflammatory response, which could be beneficial in patients with acute decompensation (AD). We therefore aimed to evaluate the effect of NSBB on 28‐day mortality and markers of systemic inflammation in a propensity score‐matched (PSM) cohort of AD patients requiring intensive care unit (ICU) admission.MethodsPatients were recruited from registry of AD patients requiring ICU admission. Out of total 445 patients, 108 patients on NSBB before admission (NSBB use group) were PSM for age, gender, pre‐admission Child–Turcotte–Pugh score and history of previous decompensation to 108 patients not on NSBB (non‐NSBB use group) which served as the control group. ICU parameters, markers of systemic inflammation and 28‐day mortality were compared by standard statistical tests.ResultsAfter PSM, no difference was observed in aetiology of cirrhosis, or precipitating event for AD between the groups. Pre‐admission creatinine, bilirubin, international normalised ratio and haemoglobin were similar between the groups, whereas pre‐admission white cell count (WCC) and neutrophil to lymphocyte ratio (NLR) was lower in NSBB‐group. On admission to ICU, NSBB group had lower heart rate (p = 0.006), platelets (p = 0.012), WCC (p = 0.006), NLR (p = 0.039) and C‐reactive protein (p = 0.007). Significantly more community acquired bacterial infections (p = 0.006), renal failure (p = 0.033) and higher grades of acute‐on‐chronic liver failure (ACLF; p = 0.012) were observed in non‐NSBB group. Significantly lower 28‐day (p = 0.001) and 90‐day (p = 0.002) mortality was seen in NSBB group. Univariate and multivariable analysis for 28‐day mortality showed that while ACLF at presentation and community acquired bacterial infection were independent negative predictors, prior NSBB use was positive predictors of survival.ConclusionsPrior use of NSBB is associated with improved 28‐ and 90‐day mortality in critically ill cirrhosis patients with AD which is mediated probably by blunting of the inflammatory response.
The pregnancy rescue case versus typical abortion
Authors: Gillham Alex R 
Published: August 2024

AbstractHendricks' pregnancy rescue case (PRC) tries to show that abortion is typically morally wrong. I argue here that there are at least two morally relevant differences between the abortion in PRC and the typical abortion so that the latter isn't morally wrong even if the former is morally wrong. I develop five modifications to PRC to show that these two differences are morally important. First, in PRC we don't know whether the person gives informed consent to the abortion, nor does the medical professional who will perform the abortion, and so the abortion can't be performed because the patient gives informed consent to it. Second, not preventing the death of the fetus in PRC brings about the death of an additional fetus gestating in a separate pregnant person, whereas most abortions don't entail the termination of another's pregnancy.
The Visible and the Invisible: Reflections on Secrecy, Dehiscence and the Gaze of the Other in the Therapeutic Encounter
Authors: de Courcier Scarlett 
Published: August 2024

AbstractPsychotherapy is broadly concerned with secrets. Often our clients bring us things which they have never told anyone, subjects they have felt unable to broach. What happens in the relationship when a secret is uncovered? In this article, I discuss how one's secrets finally being uncovered can invoke shame. However, the shame of being seen in a new way can also create an opening that allows for a deeper intersubjective experience to unfold. Using Sartre's concept of the gaze of the other alongside Merleau‐Ponty's ideas of dehiscence, visibility/invisibility and intertwining, I explore the meaning of secrecy, guilt and shame for both therapist and client within the therapeutic relationship.
Validation of Serbian version of the LittlEARS® Early Speech Production Questionnaire for the assessment of early language development in typically developing children
Authors: Nikolić Mina , Zeljković Sanja Ostojić , Ivanović Maja 
Published: August 2024

AbstractObjectiveThe LittlEARS® Early Speech Production Questionnaire (LEESPQ) was developed to provide professionals with valuable information about children's earliest language development and has been successfully validated in several languages. This study aimed to validate the Serbian version of the LEESPQ in typically developing children and compare the results with validation studies in other languages.MethodsThe English version of the LEESPQ was back‐translated into Serbian. Parents completed the questionnaire in paper or electronic form either during the visit to the paediatric clinic or through personal contact. A total of 206 completed questionnaires were collected. Standardized expected values were calculated using a second‐order polynomial model for children up to 18 months of age to create a norm curve for the Serbian language. The results were then used to determine confidence intervals, with the lower limit being the critical limit for typical speech‐language development. Finally, the results were compared with German and Canadian English developmental norms.ResultsThe Serbian LEESPQ version showed high homogeneity (r = .622) and internal consistency (α = .882), indicating that it almost exclusively measures speech production ability. No significant difference in total score was found between male and female infants (U = 4429.500, p = .090), so it can be considered a gender‐independent questionnaire. The results of the comparison between Serbian and German (U = 645.500, p = .673) and Serbian and English norm curves (U = 652.000, p = .725) show that the LEESPQ can be applied to different population groups, regardless of linguistic, cultural or sociological differences.ConclusionThe LEESPQ is a valid, age‐dependent and gender‐independent questionnaire suitable for assessing early speech development in children aged from birth to 18 months.
Reliability and validity of a measure of service providers' perceptions of child and parent engagement in pediatric rehabilitation therapy sessions
Authors: King Gillian , Chiarello Lisa A. , McLarnon Matthew J. W. , Einarson Kathleen M. , Pinto Madhu 
Published: August 2024

AbstractBackgroundThere is growing interest in client engagement in pediatric rehabilitation. This article investigated the psychometric properties of a measure of service providers' perceptions of the affective, cognitive and behavioural engagement of both children with disabilities and their parents in pediatric rehabilitation therapy sessions.MethodsTest–retest reliability of the Pediatric Rehabilitation Intervention Measure of Engagement—Service Provider version (PRIME‐SP) was examined using engagement ratings made by 60 service providers for 77 children and 73 parents. Construct validity was examined using the known‐group validity technique, utilizing service providers' ratings of the engagement of parents and their children attending the same session with the service provider. We hypothesized that there would be significantly different, yet moderately correlated engagement ratings for children and their parents.ResultsThere was evidence of moderate test–retest reliability for the child ratings, indicative of dynamicity across occasions, but also a degree of consistency, as aligned with our expectations. Service providers' ratings of parent and child engagement were not significantly correlated and paired t‐tests indicated significantly higher engagement scores for parents than children.ConclusionsThe study provides preliminary evidence to support the reliability and validity of the PRIME‐SP as a tool for service providers to document, reflect on and monitor child and/or parent engagement.
Real‐world evidence to support regulatory submissions: A landscape review and assessment of use cases
Authors: Alipour‐Haris Golnoosh , Liu Xinyue , Acha Virginia , Winterstein Almut G. , Burcu Mehmet 
Published: August 2024

AbstractReal‐world evidence (RWE) has an increasing role in preapproval settings to support the approval of new medicines and indications. The main objectives of this study were to identify and characterize regulatory use cases that utilized RWE and other related observational approaches through targeted review of publications and regulatory review documents. After screening and inclusion/exclusion, the review characterized 85 regulatory applications with RWE. A total of 31 were in oncology and 54 were in non‐oncology therapeutic areas. Most were for indications in adults only (N = 42, 49.4%), while 13 were in pediatrics only (15.3%), and 30 were in both (35.3%). In terms of regulatory context, 59 cases (69.4%) were for an original marketing application, 24 (28.2%) were for label expansion, and 2 (2.4%) were for label modification. Most also received special regulatory designations (e.g., orphan indication, breakthrough therapy, fast track, conditional, and accelerated approvals). There were 42 cases that utilized RWE to support single‐arm trials. External data to support single‐arm trials were utilized in various ways across use cases, including direct matching, benchmarking, natural history studies as well as literature or previous trials. A variety of data sources were utilized, including electronic health records, claims, registries, site‐based charts. Endpoints in oncology use cases commonly included overall survival, progression‐free survival. In 13 use cases, RWE was not considered supportive/definitive in regulatory decision‐making due to design issues (e.g., small sample size, selection bias, missing data). Overall, RWE is utilized in regulatory approval processes for new indications/label expansion across various therapeutic areas with wide range of approaches. Multifaceted cross‐sector efforts are needed to further improve the quality and utility of RWE in regulatory decision‐making.