bluuebunny/crossref_metadata_2025_split huggingface dataset:
Health-related quality of life in adolescents with congenital heart disease
Authors: Bertoletti Juliana , Marx Giovana C. , Hattge Sérgio P. , Pellanda Lúcia C. 
Published: March 2014

AbstractPurpose: This study aims to evaluate the health-related quality of life of adolescents with congenital heart disease, describing health-related quality of life according to the diagnosis and severity of congenital heart disease, identified by variables such as the presence of symptoms, surgical interventions, use of medication, and residual lesion. Methods: A cross-sectional study was conducted on 203 adolescents with congenital heart disease attended at the Pediatric Cardiology ambulatory of a reference hospital in Brazil. The Brazilian version of the questionnaire KIDSCREEN-27 was used for the assessment of health-related quality of life. Information related to the congenital heart disease diagnosis and clinical variables were collected from the medical records of the patients. Results: There was no statistically significant difference between acyanotic and cyanotic groups, as well as for the different diagnosis of congenital heart disease. A trend for better health-related quality of life in the dimension of Psychological Well-Being (p=0.054) was found in the groups with surgical intervention and use of medication. Adolescents that referred a good general health presented significantly better results in all dimensions of health-related quality of life, except for Autonomy and Parent Relation, than those who presented clinical symptoms (p<0.05). Conclusions: Type of congenital heart disease and initial diagnosis did not seem to affect the perception of health-related quality of life, corroborating findings of several studies. Surgical interventions and the use of medication can improve previous clinical status, and therefore it seems to be beneficial in terms of Psychological Well-Being. The presence of clinical symptoms was the variable that caused the largest impact on the perception of health-related quality of life, possibly because of the impairment they bring to the daily lives of these patients.
Soya and isoflavone intakes associated with reduced risk of oesophageal cancer in north-west China
Authors: Tang Li , Lee Andy H , Xu Fenglian , Zhang Taotao , Lei Jun , Binns Colin W 
Published: March 2014

AbstractObjectiveTo ascertain the association between soya consumption, isoflavone intakes and oesophageal cancer risk in remote north-west China, where the incidence of oesophageal cancer is known to be high.DesignCase–control study. Information on habitual consumption of soya foods and soya milk was obtained by personal interview. The intakes of isoflavones were then estimated using the US Department of Agriculture nutrient database. Logistic regression analyses were performed to assess the association between soya consumption, isoflavone intakes and oesophageal cancer risk.SettingUrumqi and Shihezi, Xinjiang Uyghur Autonomous Region, China.SubjectsParticipants were 359 incident oesophageal cancer patients and 380 hospital-based controls.ResultsThe oesophageal cancer patients consumed significantly less (P < 0·001) total soya foods (mean 57·2 (sd 119·0) g/d) and soya milk (mean 18·8 (sd 51·7) ml/d) than the controls (mean 93·3 (sd 121·5) g/d and mean 35·7 (sd 73·0) ml/d). Logistic regression analyses showed an inverse association between intake of soya products and the risk of oesophageal cancer. The adjusted odds were OR = 0·33 (95 % CI 0·22, 0·49) and OR = 0·48 (95 % CI 0·31, 0·74) for consuming at least 97 g of soya foods and 60 ml of soya milk daily (the highest tertiles of consumption), respectively, relative to the lowest tertiles of consumption. Similarly, inverse associations with apparent dose–response relationships were found between isoflavone intakes and oesophageal cancer risk.ConclusionsHabitual consumption of soya products appears to be associated with reduced risk of oesophageal cancer in north-west China.
DINO (Diet In Nutrients Out) – an integrated dietary assessment system
Authors: Fitt Emily , Cole Darren , Ziauddeen Nida , Pell David , Stickley Elizabeth , Harvey Anna , Stephen Alison M 
Published: March 2014

AbstractObjectiveThe current paper describes Diet In Nutrients Out (DINO), an integrated dietary assessment system incorporating dietary data entry and nutritional analysis within one platform for use in dietary assessment in small-scale intervention studies to national surveys.DesignDINO contains >6000 food items, mostly aggregated composites of branded foods, across thirty-one main food groups divided into 151 subsidiary groups for detailed reporting requirements, with fifty-three core nutrient fields.SettingMRC Human Nutrition Research (HNR), Cambridge, UK and MRC Keneba, Gambia.SubjectsDINO is used across dietary assessment projects at HNR and MRC Keneba.ResultsDINO contains macro- and micronutrients as well as additional variables of current research and policy interest, such as caffeine, whole grains, vitamin K and added sugars. Disaggregated data are available for fruit, vegetables, meat, fish and cheese in composite foods, enabling greater accuracy when reporting food consumption or assessing adherence to dietary recommendations. Portion sizes are categorised in metric and imperial weights, with standardised portion sizes for each age group. Regular reviews are undertaken for portion sizes and food composition to ensure contemporary relevance. A training programme and a checking schedule are adhered to for quality assurance purposes, covering users and data. Eating context questions are integrated to record where and with whom the respondent is eating, allowing examination between these factors and the foods consumed.ConclusionsAn up-to-date quality-assured system for dietary assessment is crucial for nutritional surveillance and research, but needs to have the flexibility to be tailored to address specific research questions.
Natural occurrence of microbial sulphur oxidation by long-range electron transport in the seafloor
Authors: Malkin Sairah Y , Rao Alexandra M F , Seitaj Dorina , Vasquez-Cardenas Diana , Zetsche Eva-Maria , Hidalgo-Martinez Silvia , Boschker Henricus T S , Meysman Filip J R 
Published: March 2014

Abstract
Recently, a novel mode of sulphur oxidation was described in marine sediments, in which sulphide oxidation in deeper anoxic layers was electrically coupled to oxygen reduction at the sediment surface. Subsequent experimental evidence identified that long filamentous bacteria belonging to the family Desulfobulbaceae likely mediated the electron transport across the centimetre-scale distances. Such long-range electron transfer challenges some long-held views in microbial ecology and could have profound implications for sulphur cycling in marine sediments. But, so far, this process of electrogenic sulphur oxidation has been documented only in laboratory experiments and so its imprint on the seafloor remains unknown. Here we show that the geochemical signature of electrogenic sulphur oxidation occurs in a variety of coastal sediment environments, including a salt marsh, a seasonally hypoxic basin, and a subtidal coastal mud plain. In all cases, electrogenic sulphur oxidation was detected together with an abundance of Desulfobulbaceae filaments. Complementary laboratory experiments in intertidal sands demonstrated that mechanical disturbance by bioturbating fauna destroys the electrogenic sulphur oxidation signal. A survey of published geochemical data and 16S rRNA gene sequences identified that electrogenic sulphide oxidation is likely present in a variety of marine sediments with high sulphide generation and restricted bioturbation, such as mangrove swamps, aquaculture areas, seasonally hypoxic basins, cold sulphide seeps and possibly hydrothermal vent environments. This study shows for the first time that electrogenic sulphur oxidation occurs in a wide range of marine sediments and that bioturbation may exert a dominant control on its natural distribution.
Sequential acquisition of multi-dimensional heteronuclear chemical shift correlation spectra with 1H detection
Authors: Bellstedt Peter , Ihle Yvonne , Wiedemann Christoph , Kirschstein Anika , Herbst Christian , Görlach Matthias , Ramachandran Ramadurai 
Published: March 2014

AbstractRF pulse schemes for the simultaneous acquisition of heteronuclear multi-dimensional chemical shift correlation spectra, such as {HA(CA)NH & HA(CACO)NH}, {HA(CA)NH & H(N)CAHA} and {H(N)CAHA & H(CC)NH}, that are commonly employed in the study of moderately-sized protein molecules, have been implemented using dual sequential 1H acquisitions in the direct dimension. Such an approach is not only beneficial in terms of the reduction of experimental time as compared to data collection via two separate experiments but also facilitates the unambiguous sequential linking of the backbone amino acid residues. The potential of sequential 1H data acquisition procedure in the study of RNA is also demonstrated here.
Effects of Dose and Age on Adverse Events Associated with Tadalafil in the Treatment of Pulmonary Arterial Hypertension
Authors: Berman‐Rosenzweig Erika , Arneson Carl , Klinger James R. 
Published: March 2014

There are limited data on the management of pulmonary arterial hypertension (PAH) in the elderly; therefore, this analysis compared the safety and efficacy of tadalafil between patients >65 and <65 years old. This was a post hoc analysis of the randomized, double‐blind, placebo‐controlled phase 3 Pulmonary Arterial Hypertension and Response to Tadalafil (PHIRST‐1) study. Patients who completed the 16‐week study or who discontinued because of clinical worsening and were not receiving tadalafil 40 mg were eligible for a long‐term, open‐label extension study. Adverse events (AEs) and efficacy outcomes were assessed in patients >65 versus <65 years old, and the dose dependency of common AEs was determined. Twenty‐eight percent (112 of 405) of patients were >65 years of age (mean in this subset, 72 ± 5 years). Compared with younger patients, elderly patients were more likely to be World Health Organization functional class III/IV (75% vs. 65%, respectively) and to have lower exercise capacity as assessed by 6‐minute walk distance (6MWD; mean, 299 vs. 366 m). Compared with placebo, tadalafil increased 6MWD by a mean of 35 and 43 m in patients >65 and <65 years, respectively. Common AEs (including headache, dyspepsia, and myalgia) were similar in both groups and tended to decrease in incidence with longer treatment duration. No differences in AEs were observed between elderly patients who received tadalafil 20 or 40 mg. In conclusion, the safety and efficacy of tadalafil for treatment of PAH are similar between elderly patients and patients < 65 years old.
How do people attempt to integrate the management of their paper and electronic documents?
Authors: Jervis Matthew , Masoodian Masood 
Published: March 2014

Purpose– This article aims to describe how people manage to integrate their use of paper and electronic documents in modern office work environments.Design/methodology/approach– An observational interview type study of 14 participants from 11 offices in eight organizations was conducted. Recorded data were analysed using a thematic analysis method. This involved reading and annotation of interview transcripts, categorizing, linking and connecting, corroborating, and producing an account of the study.Findings– The findings of the study can be categorized into four groups: the roles paper and electronic documents serve in today's offices, the ways in which these documents are managed, the problems associated with their management, and the types of fragmentation that exist in terms of their management and how these are dealt with.Practical implications– The study has identified the need for better integrated management of paper and electronic documents in present-day offices. The findings of the study have then been used to propose a set of guidelines for the development of integrated paper and electronic document management systems.Originality/value– Although similar studies of offices have been conducted in the past, almost all of these studies are prior to the widespread use of mobile and network-based shared technologies in office environments. Furthermore, previous studies have generally failed to identify and propose guidelines for integration of paper and electronic document management systems.
Reconfiguration of supply chain network: an ISM-based roadmap to performance
Authors: K. Dev Navin , Shankar Ravi , Kumar Dey Prasanta 
Published: March 2014

Purpose
– Short product life cycle and/or mass customization necessitate reconfiguration of operational enablers of supply chain (SC) from time to time in order to harness high levels of performance. The purpose of this paper is to identify the key operational enablers under stochastic environment on which practitioner should focus while reconfiguring a SC network.

Design/methodology/approach
– The paper used interpretive structural modeling (ISM) approach that presents a hierarchy-based model and the mutual relationships among the enablers. The contextual relationship needed for developing structural self-interaction matrix (SSIM) among various enablers is realized by conducting experiments through simulation of a hypothetical SC network.

Findings
– The research identifies various operational enablers having a high driving power towards assumed performance measures. In this regard, these enablers require maximum attention and of strategic importance while reconfiguring SC.

Practical implications
– ISM provides a useful tool to the SC managers to strategically adopt and focus on the key enablers which have comparatively greater potential in enhancing the SC performance under given operational settings.

Originality/value
– The present research realizes the importance of SC flexibility under the premise of reconfiguration of the operational units in order to harness high value of SC performance. Given the resulting digraph through ISM, the decision maker can focus the key enablers for effective reconfiguration. The study is one of the first efforts that develop contextual relations among operational enablers for SSIM matrix through integration of discrete event simulation to ISM.
Effect of change – a longitudinal study into the changing manufacturing structures
Authors: Kuula Markku , Putkiranta Antero , Toivanen Jarmo 
Published: March 2014

Purpose– The purpose of this paper is to analyze changes in the supply chain and production process, and the effects these changes have had on competitive performance.Design/methodology/approach– The study is longitudinal and was conducted in 1993, 2004 and 2010 with a standard questionnaire. The data have been analyzed by using the Mann-Whitney U-test.Findings– The study indicates that changing a role within the supply chain may help a company to adapt to surrounding changes, but there is no single best way to react to such changes. Companies must be able to position themselves in the new situation.Research limitations/implications– Even though the study itself and the data are unique, there are still some limitations. Although the results are limited to the sample, they nevertheless give a good insight into the changes that occurred within the sample.Originality/value– This study is the only longitudinal study in this field to compare three periods of time. This gives a unique perspective to study the changes that have occurred during the last 15 years.
Benchmarking to improve a strategy and marketing in pharmaceuticals
Authors: G. Goncharuk Anatoliy , Getman Maryna 
Published: March 2014

Purpose
– The paper is devoted to benchmark strategic ideas, organizational culture, marketing business processes and key marketing performance measures of the pharmaceutical companies that operate on Ukrainian pharma market in order to determine the best practices and possibilities of their use for the purpose of improving performance outcomes of companies participating in the research.

Design/methodology/approach
– The AllFusion Process Modeler 7 software was used for processes modeling. The Balanced Scorecard Designer software was used to create balanced scorecard. The classifier of processes at pharmaceutical companies designed by American Productivity and Quality Center (APQC) was used when determining marketing processes and building process maps. A marketing analysis (value market share, share of voice, secondary sales dynamics and companies' market share growth dynamics) was carried out in order to estimate the efficiency of marketing process.

Findings
– The study showed that three pharmaceutical companies have different strategic aims, mission and vision. For the global companies, a strategic aim is “Market takeover”, while the local company tries just to retain its position on the market due to some historically prevailing conditions. The study showed that local company's management does not consider marketing as a driving force of the development and sales growth; that is why company lacks marketing culture and marketing department as such is substituted with sales and distribution department. The authors find the needs of structural changes in order to develop, yield profit and avoid acquisition by local pharmaceutical company using the better practice of the global companies.

Research limitations/implications
– The research is limited by a little number of companies (three) and one country market (Ukraine).

Practical implications
– The study includes practical recommendations focused on the improvement of financial indicators and profitability of the local pharmaceutical company with a use of benchmarking tools. They can be useful for the other local companies that try to compete with global pharmaceutical companies on the local markets.

Originality/value
– This paper adopts the various benchmarking tools to improve a strategy and marketing processes for pharmaceutical companies.
Outsiders within: non-conformity among four contemporary black female managers in South Africa
Authors: Canham Hugo 
Published: March 2014

Purpose– The purpose of this paper is to foreground non-conformity in organisational life as it relates to black female managers. My intervention here is to problematise organisational theory in relation to its limited ability to engage with affect and to point to a more generative framework. Through centering the body, the author also seeks to offer a counter narrative to the field of Positive Organisation Scholarship and its drive to primarily engage with happy feelings and harmony.Design/methodology/approach– The author gives a close reading of four black women's interview-based narratives to engage with the ways in which they refuse to conform to organisational scripts of happiness. The author makes a case for using both critical discourse-based and affective readings of everyday experience which social science readings cannot readily account for.Findings– Non-conformity has a number of local effects including negotiating the present from a position of alternative histories of struggle and cultural values, and holding different and conflicting realities and subject positions. Moreover, a reading of these women's accounts suggests that affect is both personal and social and can manifest in multiple, embodied, transformative, and potentially destructive ways. The author comes to new ways of understanding organisations and resistance when the author uses affect as an investigative lens.Research limitations/implications– By virtue of the close reading necessitated by the nature of the study, the sample of this research is small. While the intention is not generality, the findings of the research have to be understood in context and applied within different settings with caution. The implications of this research are that there remains an urgent need for critical-orientated research which centers affect in order to counter the growing positive psychologies which relegate asymmetries to the margins.Social implications– In South Africa where black women constitute the numerical majority, there is an urgent need to understand and reverse their status as a minority in management and social life. This research goes some way in explicating this process.Originality/value– While there is well-developed body of feminist research which seeks to study black women in South Africa, there is a dearth of research into black women in the workplace. This paper therefore presents an original look at black female managers by applying international theoretical tools to a context that is under theorised. This research presents new methodological and theoretical tools and analysis to the South African workplace.
DSS for rural domestic energy planning – case study of a block in central India
Authors: J. Deshmukh Samir , Stasiak-Betlejewska Renata , Ingole Sachin , Bhuyar Lalit 
Published: March 2014

Purpose
– Most energy planning exercises are carried out with aggregate data at the national level. At regional level namely village, block/district, there have been fewer efforts for energy planning. This paper aims to present a conceptual framework for analyzing energy consumption pattern at rural domestic sector. The entire framework is designed in such a way that user is provided with helpful tips and context-sensitive help options.

Design/methodology/approach
– Decision support system (DSS) is developed with a graphical user interface (GUI) which helps to compute domestic energy consumption at a specific location. This user interface is fully menu-driven GUI in which different types of data are handled, maintained and displayed. Using this GUI, administrator can generate various reports regarding energy requirements from which decision maker can analyse the energy consumption pattern, per capita energy consumption (PCEC), adult equivalent, etc.

Findings
– DSS assists in analyzing the energy sources and demand spatially. The technologies and methods used to develop and deploy DSS to aid in domestic energy consumption make work easier for a decision maker. GUI provides user an easy access of data analysis and the design and evaluation of domestic energy consumption strategies. DSS is validated with the data pertaining to energy situation of a block in central India. Stratified sampling survey, energy analysis covering 100 households from ten villages revealed that the average value of PCEC (in kWh/day) resource-wise ranges and activity wise for the surveyed block are as follows: fuel wood (0.60), dung cake (0.085), kerosene (0.18), liquefied petroleum gas (0.052) and electricity energy for lighting and appliances (0.353) and on the other hand it is observed that cooking PCEC is highest (0.505), followed by heating (0.24), lighting (0.162), cooling (0.162) and electrical appliances (0.108).

Originality/value
– Energy analysis shows energy DSS will improve the quality of decision making at the block, district, and state level and enable the analysis and understanding of energy impacts of various decisions. Considering the Indian rural energy availability scenario, possible renewable energy solutions are also suggested to meet the current domestic energy requirements partially or fully.