bluuebunny/crossref_metadata_2025_split huggingface dataset:
Addition of Autologous Mesenchymal Stem Cells to Whole Blood for Bioenhanced ACL Repair Has No Benefit in the Porcine Model
Authors: Proffen Benedikt L. , Vavken Patrick , Haslauer Carla M. , Fleming Braden C. , Harris Chad E. , Machan Jason T. , Murray Martha M. 
Published: December 2014

Background: Coculture of mesenchymal stem cells (MSCs) from the retropatellar fat pad and peripheral blood has been shown to stimulate anterior cruciate ligament (ACL) fibroblast proliferation and collagen production in vitro. Current techniques of bioenhanced ACL repair in animal studies involve adding a biologic scaffold, in this case an extracellular matrix–based scaffold saturated with autologous whole blood, to a simple suture repair of the ligament. Whether the enrichment of whole blood with MSCs would further improve the in vivo results of bioenhanced ACL repair was investigated. Hypothesis: The addition of MSCs derived from adipose tissue or peripheral blood to the blood–extracellular matrix composite, which is used in bioenhanced ACL repair to stimulate healing, would improve the biomechanical properties of a bioenhanced ACL repair after 15 weeks of healing. Study Design: Controlled laboratory study. Methods: Twenty-four adolescent Yucatan mini-pigs underwent ACL transection followed by (1) bioenhanced ACL repair, (2) bioenhanced ACL repair with the addition of autologous adipose-derived MSCs, and (3) bioenhanced ACL repair with the addition of autologous peripheral blood derived MSCs. After 15 weeks of healing, the structural properties of the ACL (yield load, failure load, and linear stiffness) were measured. Cell and vascular density were measured in the repaired ACL via histology, and its tissue structure was qualitatively evaluated using the advanced Ligament Maturity Index. Results: After 15 weeks of healing, there were no significant improvements in the biomechanical or histological properties with the addition of adipose-derived MSCs. The only significant change with the addition of peripheral blood MSCs was an increase in knee anteroposterior laxity when measured at 30° of flexion. Conclusion: These findings suggest that the addition of adipose or peripheral blood MSCs to whole blood before saturation of an extracellular matrix carrier with the blood did not improve the functional results of bioenhanced ACL repair after 15 weeks of healing in the pig model. Clinical Relevance: Whole blood represents a practical biologic additive to ligament repair, and any other additive (including stem cells) should be demonstrated to be superior to this baseline before clinical use is considered.
Initial Validation of the Mental Health Provider Stigma Inventory
Authors: Kennedy Stephanie C. , Abell Neil , Mennicke Annelise 
Published: December 2014

Objective: To conduct an initial validation of the mental health provider stigma inventory (MHPSI). The MHPSI assesses stigma within the service provider–client relationship on three domains—namely, attitudes, behaviors, and coworker influence. Methods: Initial validation of the MHPSI was conducted with a sample of 212 mental health employees and graduate student counseling interns. Scale conceptualization and development, content validation, and construct validation measures are discussed. Results: Preliminary psychometrics indicated good model fit for a three-factor multidimensional scale. Reliabilities were strong (coefficient αs ranged from .83 to .93) and the global stratified α was .95. Evidence of construct validity supported the hypotheses about the accuracy of underlying constructs. Conclusions: The MHPSI appears to be a reliable and valid measure of mental health provider stigma. As social workers comprise the front lines of mental health service provision, the MHPSI may be a valuable tool for guiding agency trainings and social work education.
Cost-Effectiveness of Social Work Services in Aging
Authors: Rizzo Victoria M. , Rowe Jeannine M. 
Published: December 2014

Objectives: This study examines the impact of social work interventions in aging on quality of life (QOL) and cost outcomes in four categories (health, mental health, geriatric evaluation and management, and caregiving). Methods: Systematic review methods are employed. Databases were searched for articles published in English between 2004 and 2012 that report outcomes of social work interventions for aging individuals (age ≥ 50) and/or their caregivers/families. Of the 464 identified articles, 45 representing 42 studies met inclusion criteria. Results: Seventy-one percent of the studies report significant QOL outcomes. Twenty-one studies include cost outcomes, with 15 (71.4%) documenting significant cost savings. Twelve (80%) of the studies reporting significant cost outcomes examine social work interventions in health, including care coordination and end-of-life/palliative care. Conclusion: The findings suggest that social work interventions in aging have a positive and significant impact on QOL and cost outcomes. Applications for social work practice and research are discussed.
Measuring Personal Growth of New Grandparents
Authors: Orit Taubman – Ben-Ari , Shirley Ben Shlomo 
Published: December 2014

Objective: Two studies examined the validity of using the Posttraumatic Growth Inventory (PTGI) to assess growth following the transition to grandparenthood as an aid for social workers seeking to promote strengths-based interventions for this population. Method: In Study 1 ( n = 210 grandparent/offspring pairs), first-time grandparents’ spontaneous answers to a qualitative open-ended question regarding changes following the birth of their first grandchild were compared to their responses to the PTGI. To corroborate these responses, the PTGI was also completed by the grandparent’s offspring. Additionally, the study examined the applicability of the five-factor structure of the PTGI to the population of first-time grandparents. In Study 2 ( n = 202 couples), grandparents’ PTGI responses were compared with reports of their growth furnished by their spouses. Findings and conclusions: The PTGI can indeed be considered an effective instrument for measuring growth following the transition to grandparenthood and may therefore be used in designing strengths-based social work practices.
Postadoption and Guardianship
Authors: Liao Minli , Testa Mark 
Published: December 2014

Objectives: This study evaluated the effects of the Adoption Preservation, Assessment, and Linkage (APAL) postpermanency program. Method: A quasi-experimental, posttest-only design was used to estimate the program’s effects on youth discharged from foster care to adoption or legal guardianship. A random sample was surveyed (female = 44.7%; African American = 94%) and tracked with administrative data. The primary analysis estimated the program’s effect of being assigned to the intervention, whereas a supplementary analysis estimated the effects of actually receiving the services. Results: The APAL program was associated with higher levels of caregiver commitment, fewer youth behavior problems, and lower odds of placement discontinuity. Conclusion: Offering postpermanency outreach services to families might help reinforce caregiver commitment and promote children’s well-being.
Nonpain Symptom Prevalence and Intensity of Inpatients With Moderate to Severe Cancer Pain in China
Authors: Shao Yue-Juan , Ji Kai , Hao Jian-Lei , Cheng Xian-Jiang , Guan Bing-Qing , Liu Wei-Shuai , Wang Kun 
Published: December 2014

Objectives: To identify prevalence and severity of nonpain symptoms and to clarify possible influences on each nonpain symptom. Methods: The study used a descriptive survey design. Chinese version of the Edmonton Symptom Assessment System was used. Patients’ demographic and pain characteristics were collected. Results: The most common symptoms reported were loss of appetite (94.3%) followed by insomnia (93.3%), and tiredness (91.6%). Prevalence rates of nonpain symptom were all above 70% except “thinking clearly.” Prevalence and severity of nonpain symptoms varied by gender, age, primary cancer, and pain characteristics, especially intensity, number of breakthrough pain episodes per day, and number of pain sites. Conclusions: Most inpatients with cancer pain experienced concurrent nonpain symptoms. Comprehensive symptom assessment and intervention managing multiple symptoms are essential for these inpatients.
End-of-Life Care for People With Cancer From Ethnic Minority Groups
Authors: LoPresti Melissa A. , Dement Fritz , Gold Heather T. 
Published: December 2014

Background: Ethnic/racial minorities encounter disparities in healthcare, which may carry into end-of-life (EOL) care. Advanced cancer, highly prevalent and morbid, presents with worsening symptoms, heightening the need for supportive and EOL care. Purpose: To conduct a systematic review examining ethnic/racial disparities in EOL care for cancer patients. Design: We searched four electronic databases for all original research examining EOL care use, preferences, and beliefs for cancer patients from ethnic/racial minority groups. Results: Twenty-five studies were included: 20 quantitative and five qualitative. All had a full-text English language article and focused on the ethnic/racial minority groups of African Americans, Hispanics Americans, or Asian Americans. Key themes included EOL decision making processes, family involvement, provider communication, religion and spirituality, and patient preferences. Hospice was the most studied EOL care, and was most used among Whites, followed by use among Hispanics, and least used by African and Asian Americans. African Americans perceived a greater need for hospice, yet more frequently had inadequate knowledge. African Americans preferred aggressive treatment, yet EOL care provided was often inconsistent with preferences. Hispanics and African Americans less often documented advance care plans, citing religious coping and spirituality as factors. Conclusion: EOL care differences among ethnic/racial minority cancer patients were found in the processes, preferences, and beliefs regarding their care. Further steps are needed to explore the exact causes of differences, yet possible explanations include religious or cultural differences, caregiver respect for patient autonomy, access barriers, and knowledge of EOL care options.
Hallux Metatarsophalangeal (MTP) Joint Arthroscopy for Hallux Rigidus
Authors: Hunt Kenneth J. 
Published: December 2014

Arthroscopy of the hallux metatarsophalangeal (MTP) joint is an evolving technique for hallux rigidus and other disorders of the hallux MTP joint. Purported advantages of this minimally invasive procedure include rapid rehabilitation and the ability to identify and address other intra-articular and sesamoid pathologies without additional dissection. Larger, prospective, and comparative outcomes studies are needed to optimize the treatment algorithm. Level of Evidence: Level V, expert opinion.
Polarization without Parties: Term Limits and Legislative Partisanship in Nebraska's Unicameral Legislature
Authors: Masket Seth , Shor Boris 
Published: December 2014

AbstractDespite a long history of nonpartisanship, the Nebraska state legislature has polarized rapidly within the past decade. Using interviews and campaign finance records, we examine politics in the modern Unicam to investigate nonpartisan polarization. We find that newly instituted term limits created opportunities for the state's political parties to recruit and finance candidates in an increasingly partisan fashion. Social network analysis suggests that there is a growing level of structure to campaign donations, with political elites increasingly less likely to contribute across party lines. The results offer a compelling example of parties overcoming institutions designed to eliminate them.
Evaluation of Hematocrit Interference With MyStar Extra and Seven Competitive Devices
Authors: Demircik Filiz , Ramljak Sanja , Hermanns Iris , Pfützner Anke , Pfützner Andreas 
Published: December 2014

Background: In previous studies, meters employing dynamic electrochemistry (DE), have been shown to correct for hematocrit (HCT) interference. This laboratory investigation assessed the HCT stability of MyStar Extra (Sanofi) in comparison to 7 competitive devices (Accu-Chek Aviva Nano & Accu-Chek Performa, Roche Diagnostics; Contour XT and Contour Link, Bayer; FreeStyle Freedom Lite, Abbott; MyLife Pura, Ypsomed; OneTouch Verio Pro, LifeScan). Method: Venous heparinized blood was freshly drawn, immediately aliquoted, and manipulated to contain 3 different blood glucose concentrations (50-80 mg/dL, 150-180 mg/dL, and 350-400 mg/dL) and 5 different HCT levels (20-25%, 30-35%, 40-45%, 50-55%, and 60-65%). After careful oxygenation to normal blood oxygen pressure, each of the 15 different samples was measured 8 times with 2 devices and 2 strip lots of each meter (32 measurements/meter/sample). YSI Stat 2300 served as laboratory reference method. Next to determination of the mean absolute relative deviation (MARD), stability to HCT influence was assumed, when less than 10% difference occurred between the highest and lowest mean glucose deviations in relation to HCT over all tested glucose ranges (HIF: hematocrit interference factor). Results: Four of the devices showed stable performance: Contour XT (MARD: 1.3%/HIF: 6.1%), MyStar Extra (4.7%/7.1%), OneTouch Verio Pro (4.5%/7.3%), and Contour Link (6.3%/9.3%). The 4 other meters were influenced by HCT (Accu-Chek Performa: 4.7%/20.9%, Accu-Chek Aviva Nano: 4.5%/22.4%, FreeStyle Freedom Lite: 4.8%/24.5%; MyLife Pura: 6.4%/28.7%). Conclusions: In this study, all meters showed a good accuracy, but only 50% of them, including MyStar Extra, were shown to reliably correct for potential hematocrit influence on the meter results.
Septic Ankle With Purulence Tracking Up the Flexor Hallucis Longus Tendon Sheath Leading to Deep Venous Thrombosis/Pulmonary Embolism and Compartment Syndrome
Authors: Waryasz Gregory R. , McClure Philip , Vopat Bryan G. 
Published: December 2014

The differential diagnosis for lower extremity swelling and ankle pain is broad and can have overlapping and related diagnoses. If there is concern for more than one diagnosis, the practitioner should perform a thorough physical examination, order the appropriate studies, and perform the correct procedures to completely diagnose and treat the patient. This article presents the case of a 19-year-old male who presented with 5 days of left ankle pain, fevers, and swelling without any known trauma to the area. Physical examination was concerning for a septic ankle joint, cellulitis, deep venous thrombosis, and compartment syndrome. Duplex venous ultrasound confirmed a deep venous thrombosis in the popliteal vein. Joint aspiration of the ankle had gross purulence with the presence of methicillin-resistant Staphylococcus aureus. The patient was taken emergently to the operating room where he was found to have gross purulence in the deep posterior compartment, medial and lateral soft tissues of the ankle, and gross purulence in the ankle joint. The deep posterior compartment also had significant muscle necrosis and evidence of compartment syndrome. This case presents the possibility of a septic ankle leading to compartment syndrome and deep venous thrombosis/pulmonary embolism due to the intra-articular nature of the flexor hallucis longus tendon sheath. Level of Evidence: Case report, Level IV
Jacobs: GWB and the SEG Wiki: Partnering to tell the whole story
Authors: Farley Isaac 
Published: December 2014

Following the vision of the Technology Leaders Interview Series (thank you, Tad Smith and Ken Tubman), SEG Publications is launching a parallel series in The Leading Edge to highlighting the efforts in the SEG Wiki. In coming months, we will publish interviews with Matt Hall, Karl Schleicher, Don Herron, and John W. Stockwell Jr., 2014 SEG Wiki Champion, all of which were filmed in October at SEG's 2014 Annual Meeting. Watch the Wiki Interview Series debut here [Figure: see text]
Somatostatin Is Essential for the Sexual Dimorphism of GH Secretion, Corticosteroid-Binding Globulin Production, and Corticosterone Levels in Mice
Authors: Adams Jessica M. , Otero-Corchon Veronica , Hammond Geoffrey L. , Veldhuis Johannes D. , Qi Nathan , Low Malcolm J. 
Published: December 2014

AbstractDistinct male and female patterns of pituitary GH secretion produce sexually differentiated hepatic gene expression profiles, thereby influencing steroid and xenobiotic metabolism. We used a fully automated system to obtain serial nocturnal blood samples every 15 minutes from cannulated wild-type (WT) and somatostatin knockout (Sst-KO) mice to determine the role of SST, the principal inhibitor of GH release, in the generation of sexually dimorphic GH pulsatility. WT males had lower mean and median GH values, less random GH secretory bursts, and longer trough periods between GH pulses than WT females. Each of these parameters was feminized in male Sst-KO mice, whereas female Sst-KO mice had higher GH levels than all other groups, but GH pulsatility was unaffected. We next performed hepatic mRNA profiling with high-density microarrays. Male Sst-KO mice exhibited a globally feminized pattern of GH-dependent mRNA levels, but female Sst-KO mice were largely unaffected. Among the differentially expressed female-predominant genes was Serpina6, which encodes corticosteroid-binding globulin (CBG). Increased CBG was associated with elevated diurnal peak plasma corticosterone in unstressed WT females and both sexes of Sst-KO mice compared with WT males. Sst-KO mice also had exaggerated ACTH and corticosterone responses to acute restraint stress. However, consistent with their lack of phenotypic signs of excess glucocorticoids, cerebrospinal fluid concentrations of free corticosterone in Sst-KO mice were not elevated. In summary, SST is necessary for the prolonged interpulse troughs that define masculinized pituitary GH secretion. SST also contributes to sexual dimorphism of the hypothalamic-pituitary-adrenal axis via GH-dependent regulation of hepatic CBG production.
Parent and Teacher Perspectives About Problem Behavior in Children With Williams Syndrome
Authors: Klein-Tasman Bonita P. , Lira Ernesto N. , Li-Barber Kirsten T. , Gallo Frank J. , Brei Natalie G. 
Published: December 2014

AbstractProblem behavior of 52 children with Williams syndrome ages 6 to 17 years old was examined based on both parent and teacher report. Generally good inter-rater agreement was found. Common areas of problem behavior based both on parent and teacher report included attention problems, anxiety difficulties, repetitive behaviors (e.g., obsessions, compulsions, picking nose or skin), and social problems, reflecting a robust behavioral phenotype in Williams syndrome present across contexts. Some rater differences were observed; most notably, parents reported more attention and mood difficulties than did teachers, while teachers reported more oppositionality and aggression than did parents. Relations to intellectual functioning, age, and gender were examined. The implications of the findings for understanding the behavioral phenotype associated with Williams syndrome are discussed.
Gewinnung und Verarbeitung hyperspektraler Fluoreszenzbilder zur optischen Mineralklassifikation
Authors: Bauer Sebastian , Puente León Fernando 
Published: December 2014

Zusammenfassung
Auf der Suche nach schnellen, zuverlässigen und kostengünstigen Verfahren zur industriellen Mineralsortierung werden neue Wege beschritten. Wir stellen ein bisher noch nicht untersuchtes Verfahren vor: die Analyse der Mineralfluoreszenz mittels hyperspektraler Bildaufnahmen. Dabei werden die Minerale mit ultraviolettem Licht angeregt und deren Fluoreszenzantwort im sichtbaren Wellenlängenbereich spektral und örtlich aufgelöst untersucht. Es werden die hyperspektralen Aufnahmen sowie durch Bildglättung verbesserte Klassifikationsergebnisse präsentiert.
Ein intelligentes, vernetztes
präzisionsmesstechnisches Konzept als strategischer Ansatz im Forschungs- und
Industriebereich
Authors: Durakbasa Numan M. , Bas Gökcen , Bauer Jorge M. , Kräuter Lukas 
Published: December 2014

Zusammenfassung
Die Fertigungsindustrie steht zur Zeit vor den großen Herausforderungen
des globalen Wettbewerbs, die sich mit steigenden Kosten
für Energie und Rohstoffe auf der einen Seite sowie mit gesteigerten
Qualitätsansprüchen bei einer hohen
Produkttechnologie- und
Innovationserwartungs-haltung der Kunden auf der
anderen Seite beschäftigen muss. In der nächsten
Dekade wird der Gesamtfortschritt der Technik neue Strategien zur Steigerung
der internationalen Akzeptanz und positiven Bewältigung des zunehmenden
Wettbewerbs am globalen Markt erfordern.
Dieses Paper ist ein Vorschlag für einen strategischen
Ansatz, um eine fortschrittliche und intelligente
vernetzte Messtechnik mit automatisierten Mess- und
Auswerteverfahren sowie größten Genauigkeiten und kleinsten
Messunsicherheiten der Messprozesse für den
Forschungs- und Hochschulbereich,
sowie gleichzeitig für die Fertigungsindustrie zu
etablieren. An Hand eines Beispiels werden zunächst
die Modellierung der Entwicklung, die Konstruktion und
die Durchführung der Experimente in einem interuniversitären
Netzwerk gezeigt. Hierbei wird die Kooperation und
Umsetzung der Arbeitsschritte in zwei entfernten
Forschungslabors, nämlich dem
Nanotechnologie-Labor AuM der TU Wien in Österreich
und dem Regelungstechnik-Labor der
UTN-FRBA in Argentinien,
beschrieben.
Mess- und Analysemethoden in der Laserakustik bei breitbandiger Laseranregung
Authors: Singer Ferdinand 
Published: December 2014

Zusammenfassung
In dieser Arbeit werden verschiedene Methoden zur Messung und
Auswertung von akustischen Oberflächenwellen vorgestellt. Allen Methoden wird
die breitbandige Laseranregung und interferometrische Detektion der
Ultraschallwellen zu Grunde gelegt. Jede der vorgestellten Methoden ist
besonders für eine bestimmte Aufgabenstellung geeignet. Die Messprinzipien
werden zunächst theoretisch behandelt und danach mithilfe eines
laserakustischen Versuchsaufbaus praktisch angewandt. Im experimentellen Teil
der Arbeit wurden Polymer- und Nickelbeschichtungen sowie Risse in
Aluminiumplatten vermessen.
Autism cornered: network analyses reveal mechanisms of autism spectrum disorders
Authors: Auffray Charles 
Published: December 2014

Despite a wealth of behavioral, cognitive, biological, and genetic studies, the causes of autism have remained largely unknown. In their recent work, Snyder and colleagues (Li et al, 2014) use a systems biology approach and shed light on the molecular and cellular mechanisms underlying autism, thus opening novel avenues for understanding the disease and developing potential treatments.