bluuebunny/crossref_metadata_2025_split huggingface dataset:
Single-cell RNA Sequencing Identifies Natural Kill Cell-Related Transcription Factors Associated With Age-Related Macular Degeneration
Authors: Luo Yili , Liu Jianpeng , Feng Wangqiang , Lin Da , Chen Mengji , Zheng Haihua 
Published: August 2024

Background: Age-related Macular Degeneration (AMD) poses a growing global health concern as the leading cause of central vision loss in elderly people. Objection: This study focuses on unraveling the intricate involvement of Natural Killer (NK) cells in AMD, shedding light on their immune responses and cytokine regulatory roles. Methods: Transcriptomic data from the Gene Expression Omnibus database were utilized, employing single-cell RNA-seq analysis. High-dimensional weighted gene co-expression network analysis (hdWGCNA) and single-cell regulatory network inference and clustering (SCENIC) analysis were applied to reveal the regulatory mechanisms of NK cells in early-stage AMD patients. Machine learning models, such as random forests and decision trees, were employed to screen hub genes and key transcription factors (TFs) associated with AMD. Results: Distinct cell clusters were identified in the present study, especially the T/NK cluster, with a notable increase in NK cell abundance observed in AMD. Cell-cell communication analyses revealed altered interactions, particularly in NK cells, indicating their potential role in AMD pathogenesis. HdWGCNA highlighted the turquoise module, enriched in inflammation-related pathways, as significantly associated with AMD in NK cells. The SCENIC analysis identified key TFs in NK cell regulatory networks. The integration of hub genes and TFs identified CREM, FOXP1, IRF1, NFKB2, and USF2 as potential predictors for AMD through machine learning. Conclusion: This comprehensive approach enhances our understanding of NK cell dynamics, signaling alterations, and potential predictive models for AMD. The identified TFs provide new avenues for molecular interventions and highlight the intricate relationship between NK cells and AMD pathogenesis. Overall, this study contributes valuable insights for advancing our understanding and management of AMD.
Influence of Fractures and Dislocations in Severity of Rocker-Bottom Deformity in Patients with Charcot Foot
Authors: Molines-Barroso Raúl J. , López-Moral Mateo , García-Madrid Marta , García-Morales Esther , García-Álvarez Yolanda , Lázaro-Martínez José Luis 
Published: August 2024

The objective of this study was to identify bone fractures and joint dislocations that have greater association with the severity of arch collapse in patients with Charcot foot involving the midfoot. A retrospective study in 28 (N = 29 feet) patients who had Charcot foot deformity of the midfoot. The study included stage III of Eichenholtz classification, and Schon classification types I to III. Talar-first metatarsal and calcaneal pitch angles and cuboid height were used to evaluate the severity of the midfoot deformity in a weightbearing lateral radiograph. Two investigators evaluated the bone fracture and joint dislocation involved in weightbearing antero-posterior and lateral radiographs. There were 13 (46%) feet that showed pattern 1, 9 (31%) feet with pattern 2, and 7 (25%) feet with pattern 3 according to the Schon classification. One foot had a combination of patterns 1 and 2. Midfoot ulceration occurred in 64% (n = 19) of feet. In the multivariate analysis, plantarflexion of talar-first metatarsal angle was predicted by navicular-medial cuneiform dislocation (p = .007 [−20.620–3.683]), an increase of the negative calcaneal pitch angle by fragmentation of the cuboid (p = .003 [−15.568–3.626]), and increment of the negative cuboid height by navicular-medial cuneiform and medial cuneiform-first metatarsal dislocations (p = .040 [−12.779–0.317], p = .002 [−13.437–3.267], respectively). Bone fractures and dislocations in the sagittal plane seem to contribute to midfoot collapse, but navicular-medial cuneiform dislocation/non-union and cuboid fragmentation predict severe rocker-bottom deformity in cases of Charcot foot.
Clinical and radiographic outcomes after mechanical thrombectomy in medium-vessel posterior cerebral artery occlusions: Subgroup analysis from STAR
Authors: Almallouhi Eyad , Findlay Matthew C , Maier Ilko , Jabbour Pascal , Kim Joon-Tae , Wolfe Stacey Quintero , Rai Ansaar , Starke Robert M , Psychogios Marios-Nikos , Shaban Amir , Goyal Nitin , Yoshimura Shinichi , Cuellar Hugo , Howard Brian , Alawieh Ali , Alaraj Ali , Ezzeldin Mohamad , Romano Daniele G , Tanweer Omar , Mascitelli Justin , Fragata Isabel , Polifka Adam , Siddiqui Fazeel , Osbun Joshua , Crosa Roberto , Matouk Charles , Park Min S , Levitt Michael R , Brinjikji Waleed , Moss Mark , Daglioglu Ergun , Williamson Richard , Navia Pedro , Kan Peter , De Leacy Reade , Chowdhry Shakeel , Altschul David J , Spiotta Alejandro , Grandhi Ramesh 
Published: August 2024

Background Whereas mechanical thrombectomy (MT) has become standard-of-care treatment for patients with salvageable brain tissue after acute stroke caused by large-vessel occlusions, the results of MT in patients with medium-vessel occlusions (MEVOs), particularly in the posterior cerebral artery (PCA), are not well known. Methods Using data from the international Stroke Thrombectomy and Aneurysm Registry (STAR), we assessed presenting characteristics and clinical outcomes for patients who underwent MT for primary occlusions in the P2 PCA segment. As a subanalysis, we compared the PCA MeVO outcomes with STAR's anterior circulation MeVO outcomes, namely middle cerebral artery (MCA) M2 and M3 segments. Results Of the 9812 patients in STAR, 43 underwent MT for isolated PCA MeVOs. The patients’ median age was 69 years (interquartile range 61–79), and 48.8% were female. The median NIH Stroke Scale score was 9 (range 6–17). After recanalization, 67.4% of patients achieved successful recanalization (modified treatment in cerebral infarction score [mTICI] ≥ 2b), with a first-pass success rate of 44.2%, and 39.6% achieved a modified Rankin score of 0–2 at 90 days. Nine patients (20.9%) had died by the 90-day follow-up. In comparison with M2 and M3 MeVOs, there were no differences in presenting characteristics among the three groups. Patients with PCA MeVOs were less likely to undergo intra-arterial thrombolysis (4.7% PCA vs. 10.1% M2 vs. 16.2% M3, p = 0.046) or to achieve successful recanalization (mTICI ≥ 2b, 67.4%, 86.7%, 82.3%, respectively, p < 0.001); however, there were no differences in the rates of successful first-pass recanalization (44.2%, 49.8%, 52.3%, respectively, p = 0.65). Conclusions We describe the STAR experience performing MT in patients with PCA MeVOs. Our analysis supports that successful first-pass recanalization can be achieved in PCA MEVOs at a rate similar to that in MCA MeVOs, although further study and possible innovation may be necessary to improve successful PCA MeVO recanalization rates.
Effect of Lavender Essential Oil Topical Treatment on the Autonomic Nervous System in Human Subjects Without Olfactory Influence: A Pilot Study
Authors: Satou Tadaaki , Koutoku Yukino , Touma Taiga , Tomiyama Ryuto , Ishikawa Ayumi , Odato Kai 
Published: August 2024

Objective/background As part of a scientific study into the effects of aromatherapy, we investigated the effects of lavender essential oil (LEO) treatment on the autonomic nervous system in subjects for whom the sense of smell had been eliminated. Methods This study used a single-blinded cross-over design for verification. Heart rate variability was measured and effects on the autonomic nervous system were investigated. Results and discussion Although no significant differences were found, aromatherapy treatment with 1% LEO tended to increase parasympathetic nervous system activity. Further, when differences between values before and during aromatherapy treatment were compared, LEO treatment significantly increased parasympathetic nervous system activity. Given these findings, LEO appears to increase parasympathetic nervous system activity, even in the absence of a psychological effect due to an absence of olfactory stimulation. Conclusion The present results provide a scientific method for verifying the effects of aromatherapy and will aid in further elucidation of aromatherapy.
A refined ICD-10 diagnoses-based approach for retrospective analysis of potential palliative care need and coverage in claims data of deceased
Authors: Slotina Ekaterina , Ditscheid Bianka , Meissner Franziska , Marschall Ursula , Wedding Ulrich , Freytag Antje 
Published: August 2024

Objectives: ICD-10-based approaches often provide the basis for retrospective estimation of potential palliative care need. Applying the ICD-10-based Murtagh et al. classification from 2014 (Murtagh classification), developed using mortality data, to administrative claims data leads to inconsistencies in estimating palliative care need. The aim of the study was to refine the classification for palliative care need estimation in deceased individuals with cancer and non-cancer diagnosis. Methods: A retrospective population-based study comparing Murtagh classification to a new ICD-10-based classification (revised by expert opinion) was conducted using outpatient and inpatient claims data, including billing codes for palliative care. Palliative care need was estimated for diagnoses groups and was contrasted with palliative care utilization rates in the last year of life. Our dataset included records of 417,405 individuals who deceased in 2016–2019. Results: Out of individuals deceased in 2019 ( n = 117,436), 81.4% had at least one diagnosis from the new classification, while 97.0% had at least one diagnosis from the Murtagh classification. Classification revision thus identified fewer individuals as potentially in need of palliative care. Among individuals with cancer, 70.7% (vs. 55.7% via Murtagh classification) received palliative care. In non-cancer subgroups, the utilization rate was considerably lower, with a maximum of 36.7% (vs. 33.7% via Murtagh classification) in 2019. Similar results were observed for the other years. Conclusion: Compared to the ICD10-based Murtagh classification, the revised ICD-10-based classification enables more realistic estimations if the cause of death is unavailable and reveals higher rates of palliative care coverage and differences especially in cancer versus non-cancer diseases. German Clinical Trials Register (DRKS00024133).
Digital health literacy and associated factors among health professionals during the outbreak of corona virus pandemic in Ethiopia: A systematic review and meta-analysis
Authors: Kasaye Mulugeta Desalegn , Kebede Natnael , Kalayou Mulugeta Hayelom , Kebede Shimels Derso , Molla Asressie 
Published: August 2024

Introduction The COVID-19 pandemic had a significant impact on healthcare delivery worldwide. Digital tools emerged as a preferred solution for maintaining healthcare services during this crisis. This study aimed to assess the magnitude of digital health literacy among healthcare professionals in Ethiopia in 2020–2023. Methods A systematic review and meta-analysis were conducted following the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) guidelines. Articles published from 2020 to 2023 were reviewed using various electronic databases such as Medline, PubMed, and Cochrane Library, CINAHL, HINARI, Science Direct, Google Scholar, and Global Health. Meta-analysis was performed using STATA 17, and publication bias and heterogeneity were assessed. Results Six studies involving a total of 2739 participants were included in the analysis. The pooled level of high digital health literacy among health professionals in Ethiopia during the pandemic was found to be 56.0% (95% CI: 55, 58). Several factors were identified as significant contributors to high digital health literacy, including internet use (AOR = 2.72, 95% CI: 1.86, 3.98), perceived ease of use (AOR = 2.79, 95% CI: 1.83, 4.25), favorable attitude (AOR = 2.49, 95% CI: 1.61, 3.85), perceived usefulness (AOR = 2.29, 95% CI: 1.65, 3.18), information-communication-technology training (AOR = 6.09, 95% CI: 1.83, 24.27), and educational level (AOR = 3.60, 95% CI: 2.96, 4.37). Conclusion and recommendation The study findings revealed a moderate level of high digital health literacy among Ethiopian health professionals. Factors such as internet use, favorable attitude, and information-communication-technology training were associated with high-level digital health literacy. To enhance digital health literacy, it is crucial to provide timely training and improve internet access for healthcare professionals. Additionally, promoting the perception of digital tools as useful and supporting evidence-based decision-making can further improve digital health literacy. Comprehensive information-communication-technology training programs should be implemented to equip healthcare professionals with necessary skills to effectively combat outbreaks like the COVID-19 pandemic.
Risk Factors for Depression Among Middle-Aged to Older People Living With HIV in Lima, Peru
Authors: Failoc-Rojas Virgilio E , Jia Dan Tong , Gil-Zacarias Marcela , Latorre Alana , Cabello Robinson , Garcia Patricia J , Diaz Monica M 
Published: August 2024

Introduction Depression is prevalent among aging people living with HIV (PLWH) worldwide. We sought to identify depression risk factors among a group of middle-aged and older PLWH in Lima, Peru. Materials and Methods We assessed risk factors for depression among PLWH over age 40 receiving care in an HIV clinic in Lima, Peru. The Patient Health Questionnaire-9 (PHQ-9) was administered. We performed descriptive statistics and logistic regression analyses. Results Mean age was 51.7 ± 7.7 years with 15.3% females. One-quarter of participants had depression with higher frequency in females. Risk factors that significantly increased the risk of depression included female sex (adjusted prevalence ratio [aPR] = 2.19 [95%CI 1.07-4.49]), currently smoking (aPR = 2.25 [95%CI 1.15-4.43]), and prior opportunistic infection (aPR = 2.24 [95%CI 1.05-4.76]). Discussion Our study demonstrates that PLWH who are female, current smokers, or had an opportunistic infection have higher risk of depression. Identifying PLWH at-risk for depression is key to early mental health interventions.
Fostering the Job Performance of Nurses: A Responsibility of an Ethical Hospital
Authors: Thuy Hua Thanh , Lan Bui Thi 
Published: August 2024

Introduction Corporate social responsibility (CSR) practices refer to the deliberate actions and strategies implemented by a company or organization to generate positive outcomes for its stakeholders beyond the sole objective of profit maximization. Internal CSR is a significant management and investment concept within enterprises, such as hospitals, that enhances organizational performance excellence. Objectives The article aims to trace how hospitals thrive in nurses’ job performance by leveraging internal CSR practices. Methods Cross-sectional design quantitative research through structured questionnaire interviews on 215 nurses in Vietnam. Data collection was conducted from May 2023 to August 2023. Partial least squares structural equation modeling was applied to test the hypotheses. Results The study has proven that a hospital's internal CSR practices impact nurses’ job performance. Income and benefits, human resource training and development, and work-related quality of life directly and significantly impact three dimensions of a nurse's job performance (competence to practice patient care, attitude to performance work, and management and professional development capacity). Connection and trust in the workplace and health and safety at work significantly affect two dimensions of a nurse's job performance (namely, competence to practice patient care and attitude to performance work). Diversity in the workplace impacts nurses’ competence in practicing patient care and their management and professional development capacity. Demographic variables did not correlate statistically significantly with dimensions of internal CSR and nurses’ job performance. Conclusion The study presents significant findings on the influence of internal CSR on nurses’ job performance within the hospital management theory of an emerging market. The results of the present study contribute to a better understanding of the benefits of hospitals’ socially responsible actions and contribute further to resource management in hospitals, especially nursing. If the nursing staff positively perceives the hospital's internal CSR practices, they will be more able to perform their job, impacting the hospital's overall performance. This study has certain limitations regarding the representative nature of the sample, the use of the self-report survey instrument, and the use of cross-sectional data.
Experiment analysis on defects in ultrasonic-assisted drilling of carbon fiber reinforced plastic with different diameter drills
Authors: Hu Chen , Han Sheng , Chen Meiling , Zhu Yongwei 
Published: August 2024

Carbon fiber reinforced polymers (CFRP) are increasingly used in aerospace, military, and automotive applications due to their high specific strength and corrosion resistance. CFRP components usually require small-hole machining before assembly. CFRP parts are susceptible to defects such as tears and uncut fibers during hole machining. Ultrasonic-assisted drilling (UAD) contributes to the suppression of their defects. However, preliminary experiments revealed that the effect at different diameters is not the same. Therefore, this paper innovatively compares the effect of ultrasonic-assisted machining on the suppression of defects under different hole diameters and investigates the mechanism. The effects of machining parameters such as ultrasonic power, feed rate, and rotational speed on burr and tear defects of holes under different hole diameters are experimentally studied and theoretically analyzed. It was shown that the lowest defective machined holes were obtained at 50% (4 μm) ultrasonic power for all hole diameters, while higher ultrasonic power would result in an increase in machining defects. Compared with small hole diameters, there are relatively fewer uncut fibers at large hole diameters, but the tearing defects are more severe. The defect suppression effect of ultrasound is more pronounced at larger holes. The change in cutting force due to ultrasound is an important reason for the difference in machining defects. At a diameter of 6 mm, the longitudinal cutting force decreased by 58.7%, while uncut fibers and tearing defects decreased by 45.1% and 12.6%, respectively. This study can provide a theoretical basis for the selection of ultrasonic power and other parameters when machining holes of different diameters.
Developing a Menopausal Transition Health Promotion Intervention With Indigenous, Integrative, and Biomedical Health Education: A Community-Based Approach With Urban American Indian/Alaska Native Women
Authors: Taylor-Swanson Lisa , Kent-Marvick Jacqueline , Austin Sharon Déezbaaˈ , Ellis Jessica , Charles Claudia , Ward Ryan , Crandall Leslie , Macias Saraí Negrete , Moreno Camille , Simonsen Sara E 
Published: August 2024

Background Few studies have examined the menopausal transition in American Indian and Alaska Native (AI/AN) women; these reports indicate they are the most likely group to report bothersome vasomotor symptoms (VMS). Evidence demonstrates VMS may be a biomarker for chronic diseases. Thus, evidence-based interventions to improve VMS and other symptoms and health-screening rates for urban midlife AI/AN women are needed. Objective The objectives of this community-based project were to form a Community Advisory Board (CAB) with whom to: 1) conduct CAB meetings (similar to a focus group) with midlife AI/AN women to understand their lived health care experiences and needs during the menopausal transition; and 2) obtain guidance in creating a tailored intervention. Methods Eligible participants indicated they were registered members of American Indian Tribes, self-identified as a woman, aged 35 or older, and were recruited through the Urban Indian Center of Salt Lake and community outreach. Three CAB meetings were conducted via Zoom. A qualitative-descriptive approach was used for analysis, with the aim of staying close to the data to understand AI/AN women’s experiences and needs. Transcripts were iteratively coded using content/thematic analysis. Results Four themes emerged: 1) lack of and desire for information about the menopause transition; 2) barriers to accessing care; 3) matriarchal priorities impacting personal health outcomes; and 4) preferences for Indigenous and integrative medicine as first-line interventions, followed by conventional medicine. Conclusions Among this sample of urban AI/AN women, there was a great need for and interest in information about menopause, both for themselves and for their daughters and family. Integrative and Indigenous approaches were preferred. Proposed next steps include developing and pilot-testing a nurse-delivered health-education intervention with Indigenous, integrative, and conventional medical content.
Polyethylene liner dissociation in total hip arthroplasty: a retrospective case–control study on a single implant design
Authors: Pagano S. , Plate J. F. , Kappenschneider T. , Reinhard J. , Scharf M. , Maderbacher G. 
Published: August 2024

Abstract
Background
Modular acetabular components for total hip arthroplasty (THA) provide intraoperative flexibility; however, polyethylene liner dissociation may occur. This study aimed to examine the incidence and causes of liner dissociation associated with a specific acetabular component design at a single centre.

Materials and methods
A retrospective analysis of 7027 patients who underwent primary THA was performed to identify isolated liner dislocations. Patient demographics, clinical presentations, surgical and implant details, and both radiographic and computed tomography (CT) findings were analysed. Patients with liner dislocation were matched to a control group via 2:1 propensity score matching, and a logistic regression analysis was employed to identify associated risk factors.

Results
A total of 32 patients (0.45%) experienced liner dislocation at a mean 71.47 ± 60.10 months post surgery. Significant factors contributing to dislocations included the use of a conventional compared with a highly crosslinked polyethylene component (p = 0.049) and screw fixation (p = 0.028). Radiographic and CT analysis highlighted the importance of proper component orientation, revealing that patients experiencing dislocations demonstrated significantly lower acetabular cup anteversion angles (p = 0.001) compared with the control group. Impingement and malposition, identified in 41% and 47% of the cases, respectively, further underscored the multifactorial nature of dislocation risks.

Conclusions
While the overall rate of polyethylene liner dislocation was low, the findings of this study highlight the importance of appropriate cup placement to decrease the risk of dissociation. It further substantiates the influence of impingement and malposition in liner displacement, with increased mechanical stress exerted on the locking mechanism under adverse conditions and the potential risk increase due to screw placement.