bluuebunny/crossref_metadata_2025_split huggingface dataset:
Incontinencia urinaria y el fortalecimiento de la musculatura pélvica para mejorar la calidad de vida en mujeres
Authors: Sánchez Gadvay Andrea Estefanny , Barreno Gadvay Alex Daniel , Orozco Orozco Andrés Santiago , Vallejo Chinche Silvia del Pilar 
Published: February 2025

Introducción. La incontinencia urinaria (IU) es un problema social que afrontan en mayor porcentaje las mujeres con una relación de afectación de 1:4 sufriendo IU. Se considera como IU a la perdida involuntaria de orina, afectando a la productividad y calidad de vida de quien lo padece acompañado de depresión, ansiedad, y un aumento de infecciones del tracto urinario inferior. Se estima que entre un 25% y 45% de los factores, en mujeres se debe al envejecimiento, embarazo y partos vaginales; los tipos de incontinencia urinaria son: incontinencia urinaria de esfuerzo (IUE), incontinencia urinaria de urgencia (IUU) y la incontinencia urinaria mixta (IUM). El trabajo de fortalecimiento de la musculatura de suelo pélvico (MSP) se ha convertido en un tratamiento conservador de primera línea, para la rehabilitación frente a esta patología. Objetivo. Exponer las generalidades de la Incontinencia Urinaria, y la influencia del fortalecimiento de la musculatura de suelo pélvico y como interviene en la calidad de vida de las mujeres. Metodología. Se realizó una revisión narrativa de la literatura, en primera instancia se efectuó la búsqueda en las bases de datos; Pubmed (69), Embase (407), Pedro (25) y Trip (0), encontrando un total de 501 artículos, de los cuales se realizó una primera selección por título con las palabras claves “exercise and training and incontinence and quality of life”, se seleccionaron respectivamente 10 artículos para realizar este estudio. Resultados y Conclusión: Es necesario el fortalecimiento de la musculatura del suelo pélvico para disminuir los episodios de incontinencia urinaria. Los programas dirigidos de forma grupal generan mejores beneficios y resultados en comparación del trabajo individual, por el apoyo en conjunto entre los grupos de mujeres, mejorando la calidad de vida. En un total de 2449 mujeres que fueron intervenidas en los estudios revisados, el fortalecimiento de suelo pélvico, tanto de forma grupal e individual obtuvieron resultados a las 6 y 12 semanas, la intervención se realizó entre 2 a 3 veces por semana con una duración de 40 a 50 minutos la sesión. Área de estudio general: Fisioterapia. Área de estudio específica: Suelo pélvico. Tipo de estudio: Artículos originales.
Drug susceptibility of uropathogens isolated from patients treated at the Mazovian Specialized Hospital in Radom
Authors: Trześniewska-Ofiara Zuzanna , Mendrycka Mariola , Woźniak-Kosek Agnieszka 
Published: February 2025

Urinary tract infections (UTI) are a significant problem among populations worldwide. It is mainly associated with the increasing incidence of recurrence, complications and the increasing drug resistance of uropathogens. The aim of this study was to demonstrate the prevalence of resistance among pathogens causing urinary tract infections. The material for the study was data obtained from the Mazovian Specialized Hospital (M.S.H) in Radom over a period of 2 years. Urine was collected from hospitalized patients with UTI. Statistical calculations were performed using statistical software. During the study period, 3,917 patients underwent microbiological examination of urine, and almost 15% of them were found to be infected with UTI. Based on statistical analysis of drug susceptibility of the most common uropathogens, it was shown that urinary tract infections caused by Escherichia coli or Klebsiella pneumoniae, among others, often show high resistance to fluoroquinolones and β-lactam antibiotics. Proteus mirabilis strains have been shown to be more resistant to aminoglycosides and fluoroquinolones than to beta-lactams. In the case of Pseudomonas aeruginisa, resistance to fluoroquinolones predominates. On the other hand, UTI caused by Acientobacter baumannii should be treated based on the results of drug susceptibility testing due to the increasing prevalence of multidrug-resistant strains.
ChMER: an exoskeleton robot with active body weight support walker based on compliant actuation for children with cerebral palsy
Authors: Ding Yuantao , Wang Zhengtao , Yang Peizhong , Yu Suiran 
Published: February 2025

IntroductionLower limb exoskeleton robots for young children with cerebral palsy (CP) are crucial to support earlier rehabilitation that is more beneficial than later. For safety reasons, pediatric exoskeletons are usually equipped with body weight support (BWS) devices to help young patients maintain balance. However, existing pediatric exoskeletons tend to use stiff joint actuation and passive BWS with limited compliance.MethodThis paper proposes a novel mobile exoskeleton robot for young children (3- ∼ 6-years-old) with CP based on intrinsically compliant actuation. A compact kinematic chain that integrates an exoskeleton, an active BWS system, and a walker is proposed. Furthermore, with the actuation design optimization of the kinematic chain, the robot can walk alone stably in passive rehabilitation and provide high compliance in active rehabilitation. The exoskeleton adopts actuation similar to the quasi-direct drive paradigm to acquire high mechanical compliance and uses a secondary planetary reducer to ensure high output torque. Assistive torque control is achieved through proprioceptive sensing instead of torque sensors. The BWS system uses a series elastic actuator to accurately generate the weight support force and significantly reduce the fluctuation of the support force compared to the passive BWS.Results and discussionFinally, control frameworks for passive and active rehabilitation are implemented to validate the robot performance. The experimental results demonstrate that our robot can support safe and compliant rehabilitation.
Age-specific kinetics of neutralizing antibodies and infection enhancement among ≤1 year-old Indian infants
Authors: Chelluboina Shweta , Mishra Akhilesh Chandra , Arankalle Vidya Avinash , Shrivastava Shubham 
Published: February 2025

BackgroundInfants born to dengue-immune mothers acquire maternal antibodies to dengue. Maternal antibodies decline over time, making infants susceptible to primary dengue infections. Another important concern is the role of maternal antibodies in causing antibody-dependent enhancement (ADE) during primary infections. In this study, we aimed to investigate the kinetics of dengue virus (DENV)-neutralizing antibodies and infection-enhancing activity in Indian infants.MethodsHealthy infants at birth (cord blood), and at 3, 6, 9, and 12 months of age (n=32/group) were included in this cross-sectional study. Serum samples were tested for neutralizing antibodies using the foci-reduction neutralization test and enhancing antibodies using the ADE assay against DENV1-4 serotypes.ResultsNeutralizing antibody positivity declined with the increasing age of the infants. Undetectable levels of neutralizing antibodies to DENV1-4 serotypes were reported in 84% of infants by 9 months. Significantly lower neutralizing antibody titers were also reported in 9-month-old infants compared to that in 6-month-old infants and infants at birth. Comparable levels of enhancement of DENV1-4 infection at a particular dilution to at least one serotype were noted in infants at 3 and 6 months of age. Fold enhancement of DENV1-4 infection was found to be highest in 6-month-old infants at a dilution of 1:20. In summary, our data suggests that DENV infection–enhancing activity aligns with the decline of neutralizing antibodies.ConclusionOur study indicates that maternally acquired neutralizing antibodies could be protective until 6 months of age and capable of facilitating ADE on exposure to dengue infections in later months of life.
Impact of self-reported SARS-CoV-2 antibody positivity on cardiac structure and function: findings from UK Biobank CMR cohort
Authors: Liu Chang , Ma Yao , Qiao Shiyuan , Li Kexin , Qi Mengyao , Gu Chunyu , Zhang Lanxin , Wei Jia , Gao Dengfeng 
Published: February 2025

BackgroundSARS-CoV-2 antibody positivity, whether due to natural infection or vaccination, is known to be associated with specific cardiac and vascular damage, yet its impact on cardiac structure and function in prospective cohorts remains incompletely understood.ObjectiveWe aimed to assess cardiac changes in the UK Biobank cohort among individuals with self-reported seropositive results for SARS-CoV-2 antibodies.MethodsUK Biobank participants with self-reported serological results for SARS-CoV-2 antibodies, who underwent their first cardiac magnetic resonance (CMR) scan after 2019 were included. Cardiac changes potentially associated with SARS-CoV-2 antibody positivity were assessed, with measurements of left ventricular (LV) parameters, including volume, dimensions, wall thickness, myocardial mass, cardiac output (CO), and cardiac index (CI), manually extracted from the CMR images. Propensity score matching (PSM) was used to pair seropositive and seronegative individuals. Native T1 was used to assess the within-subject changes in seropositive individuals. Logistic regression was performed to assess the association between SARS-CoV-2 antibody status and the incidence of LV hypertrophy.ResultsA total of 720 participants were included, with 453 individuals self-reporting as SARS-CoV-2 antibody positive. After PSM, 261 participants remained in each group. Over an average follow-up period of 110 days, significant decreases in CO and CI were observed in the paired participants. Additionally, native T1 values appeared to be elevated in seropositive participants (852.77 ± 53.55 ms vs. 860.01 ± 47.81 ms, P = 0.012). Logistic regression analysis in the overall cohort indicated an association between SARS-CoV-2 antibody positivity and an increased risk of LV hypertrophy, with an adjusted odds ratio of 3.257 [95% CI (1.036–10.239), P = 0.043].ConclusionsOur findings suggest subtle cardiac changes associated with SARS-CoV-2 antibody positivity within approximately hundred days. SARS-CoV-2 antibody positivity appeared to be associated with an increased risk of LV hypertrophy. However, these results are exploratory, and further longitudinal studies with extended follow-up are needed to better understand the long-term cardiac impact of SARS-CoV-2 antibody positivity.
Comparative effectiveness of exercise interventions on arterial stiffness in individuals at risk for cardiovascular disease: a systematic review and network meta-analysis
Authors: Wu Ruo-Shan , Zhang Yan , Yuan Xin-Wang , Yan Xin , Fu Xiao-Lei 
Published: February 2025

BackgroundPrevious studies have shown that exercise can improve arterial stiffness (AS). However, it remains unclear which type of exercise is most effective for managing AS, particularly in individuals at high risk for cardiovascular diseases (CVD). This review aims to evaluate the effects of various exercises on AS and related variables in individuals at high risk for CVD.MethodsA comprehensive search strategy was employed to systematically explore MEDLINE (PubMed), Embase, Cochrane Library, EBSCOhost, and Web of Science to identify relevant studies. Inclusion criteria were: (1) randomized controlled trials; (2) participants with known CVD risk factors as per the American College of Sports Medicine guidelines; (3) interventions including interval training (INT), aerobic exercise (AE), resistance exercise, and combined exercise (CT); (4) control groups engaging in no intervention, routine care, or health education; (5) outcome measures of pulse wave velocity (PWV), systolic blood pressure (SBP), and diastolic blood pressure; and (6) studies published in English. Studies were assessed using the Cochrane risk of bias tool and analyzed with a random-effects network meta-analysis.ResultsThe review included 2,034 participants from 43 studies. Both CT [standardized mean difference (SMD) = −0.98, p &lt; 0.001, I2 = 84%] and INT (SMD = −0.77, p &lt; 0.001, I2 = 61%) significantly reduced PWV, but both showed considerable heterogeneity. INT (SMD = −0.382, p &lt; 0.001, I2 = 45%) and AE (SMD = −0.369, p &lt; 0.001, I2 = 43%) significantly reduced SBP. Surface under the cumulative ranking curve (SUCRA) showed that CT (SUCRA = 87.2) was the most effective for lowering PWV, while INT (SUCRA = 81.3) was the most effective for lowering SBP.ConclusionIn high-risk populations for CVD, CT was most effective in improving AS, while INT demonstrated the greatest reduction in SBP. AE showed greater benefits at moderate to low intensities. Due to significant heterogeneity in CT, its results should be interpreted with caution. Further research with larger sample sizes is needed to confirm these findings.
Using a wider digital ecosystem to improve self-regulated learning
Authors: Domino Molly , Shaffer Clifford A. 
Published: February 2025

IntroductionSelf-regulated learning skills are necessary for academic success. While not all students entering post-secondary education are proficient at many of these critical skills, they can be improved upon when practiced. However, self-regulation tends to be highly internal, making it difficult to measure. One form of measurement comes from using data traces collected from educational software. These allow researchers to make strong empirical inferences about a student's internal state. Automatically captured data traces also make it possible to provide automated interventions that help students practice and master self-regulated learning skills.Methods/resultsUsing an experimental methodology we created a set of promising data traces that are grounded in theory to study self-regulated learning within a typical Computer Science course. Extra attention is given to studying the skill of help-seeking, which is both a key to success in CS and requires unobtrusive observation to properly measure.DiscussionWe also make the case for taking a broader perspective with our data collection efforts. The traces identified in this paper are not from one source, but the full ecosystem of software tools common to CS courses.
Nurturing bonds that empower learning: a systematic review of the significance of teacher-student relationship in education
Authors: Di Lisio Giulia , Milá Roa Antonio , Halty Amaia , Berástegui Ana , Couso Losada Alba , Pitillas Carlos 
Published: February 2025

BackgroundTeachers are regarded as attachment-like figures, with positive and supportive teacher-student relationships (TSRs) being linked to improved academic performance and outcomes, while negative TSRs are associated with lower academic results. This systematic review aims to map the relational dimensions of the TSR and its impact on academic (dis)engagement, (under)achievement and early school leaving (ESL), focusing on Secure Base and Safe Haven attachment dimensions and the influence of vulnerability factors.MethodsThe review followed the PRISMA guidelines and included 45 empirical quantitative studies (2018–2022) sourced from Academic Search Complete, ERIC, Scopus and Web of Science. Inclusion criteria were English-written quantitative methodology studies, with TSR as the independent variable and academic outcomes as the dependent variable. Exclusion criteria included longitudinal designs, purely qualitative studies, correlational analyses, studies lacking key variables or presenting reversed relationships, those conducted in e-learning environments, university settings, extreme schooling conditions and non-English language studies. A descriptive and narrative style analysis was used to synthesize the results based on Safe Haven, Secure Base and Global dimensions.Results and discussionKey findings highlighted the significant role of TSR in influencing academic engagement, achievement, and ESL, particularly from vulnerable populations. The synthesis of results indicated that positive TSRs are associated with improved academic outcomes, while negative TSRs can exacerbate disengagement and underachievement. Limitations of the evidence included potential publication bias and the lack of quality control measures, as well as the exclusion of longitudinal and qualitative studies. The findings underscore the significance of a holistic understanding of the TSR in education, highlighting its multifaceted impact on student success and suggesting that future research should consider qualitative and longitudinal studies and expand the scope to studies in non-English language.
Increased sputum peripheral helper T cells are associated with the severity of rheumatoid arthritis but not with the severity of airway disease
Authors: Yokoi Eito , Wakahara Keiko , Nakamura Saya , Fukutani Eriko , Asai Shuji , Takahashi Nobunori , Kojima Toshihisa , Iwano Shingo , Shimada Satoko , Chen-Yoshikawa Toyofumi Fengshi , Hashimoto Naozumi , Ishii Makoto 
Published: February 2025

ObjectivePeripheral helper T (Tph) cells, together with plasma cells, are the major pathogenic lymphocytes in the synovium in rheumatoid arthritis (RA). However, whether these cells are involved in RA-associated lung and/or airway disease is unknown.MethodsTph cells in sputum were analyzed by flow cytometry and compared with those in synovial fluid and synovial tissue. Forty RA subjects for whom induced sputum could be collected were analyzed along with sputum Tph cells and several clinical parameters; RA severity was assessed using the Disease Activity Score for 28 joints (DAS28). Lung and airway disease was assessed by chest computed tomography (CT), pulmonary function test, the chronic obstructive pulmonary disease (COPD) Assessment Test (CAT), and sputum culture. Tph cells in the lung of RA subjects were analyzed using lung resection samples in a separate cohort.ResultsTph cells were observed in the sputum, as well as the lung, synovial fluid, and synovial tissue of RA patients. Sputum Tph cells were increased in patients with airway disease. Among these patients, Tph cells were more frequent in those with high DAS28, high serum immunoglobulin G (IgG), and high sputum IgG. However, there was no association between Tph cells and the severity of airway disease as assessed by chest CT findings, lung function, CAT, and sputum culture.ConclusionsTph cells were increased in the airways as well as in the synovium in patients with RA. Airway Tph cells were associated with severity of RA but not with the severity of airway disease. Airway Tph cells may represent a novel target for disease management and treatment.
Yiqi Huayu Jiedu Decoction reduces colorectal cancer liver metastasis by promoting N1 neutrophil chemotaxis
Authors: Zhou Hua-Jian , Mu Bai-Xiang , Wen Meng-Chao , Zhao Qi , Li Yuanxiang , Zhao Wen-Xuan , Yin Hong-Ye , Ren Shuai , Zhou Jin-Yong , Chen Min 
Published: February 2025

ObjectiveTo observe the inhibitory effect and potential mechanism of Yiqi Huayu Jiedu Decoction (YHJD) on liver metastasis of colorectal cancer (CRC).MethodsWe compared the changes of liver weight and liver index before and after YHJD treatment in CRC liver metastasis mouse models. HE staining was employed to observe the pathological changes in mouse liver tissue sections. Flow cytometry was used to analyze the number and marker of neutrophils treated with YHJD. Transcriptomics, proteomics, and multiplex cytokine array analyses were conducted to further verify the role of YHJD on CXCL1. Differential gene analysis was performed to further explore the mechanism by which YHJD inhibits liver metastasis of CRC.ResultsAnimal studies demonstrated that YHJD reduces liver metastases. Flow cytometry results revealed that YHJD promotes N1 neutrophils in liver. Combining multi-omics and multiple cytokine arrays, we observed a significant increase in the expression of CXCL1 in the liver and plasma. GO and KEGG enrichment analyses indicated that YHJD may regulate the chemotaxis of neutrophils to inhibit the liver metastasis of CRC by participating in the regulation of cell adhesion molecule binding, adhesion protein binding, and multiple metabolic pathways.ConclusionsYHJD inhibits CRC liver metastasis by upregulating CXCL1, thereby promoting N1 neutrophil chemotaxis towards the liver, and concurrently raising the expression of N1 neutrophil markers.
Identification of B-cell epitopes of Indian Zika virus strains using immunoinformatics
Authors: Roy Rohan Raj , Tadkalkar Nitali , Deshpande Gururaj Rao , Atre Nitin M. , Shil Pratip , Sapkal Gajanan 
Published: February 2025

IntroductionThe Zika virus is an emerging Flavivirus known to cause Zika infection in humans. It is associated with severe health problems such as microcephaly and Guillain-Barré syndrome post the Brazilian epidemic in 2015-16. The spread of the Zika virus to the Asian subcontinent, especially to India is a matter of great concern. Two recent co-circulating Indian Zika virus strains such as Rajasthan and Maharashtra detected in 2018 and 2021 were studied to identify B-cell epitopes in the envelope and non-structural 1 protein as these epitopes are major indicators of robust humoral immune response. The study aimed at identifying novel epitopes, followed by molecular docking with potent Zika virus-specific monoclonal antibodies. The novel epitopes identified in this study shall be essential in designing multi-epitope vaccines capable of inducing antibody response against Zika virus infection.MethodsABCpred, BepiPred 2.0 and Kolaskar-Tongaonkar methods were used for predicting the linear B-cell epitopes, and Discotope 2.0 and ElliPro were used for the prediction of conformational epitopes. Linear epitopes were further checked for protective antigenicity, allergenicity and toxicity. Based on the stringent study design criteria, only the novel epitopes were considered for molecular docking with complementary determining regions of potent Zika virus-specific monoclonal antibodies.ResultsNineteen linear and five conformational epitopes were shortlisted based on protective potential, non-allergic and non-toxic properties for Zika virus E protein, from which nine linear and three conformational epitopes were identified as novel. Molecular docking studies revealed that the novel linear epitopes, one each from EDIII, EDII, EDI and EDI/DIII hinge were involved in epitope-CDR interactions with potent neutralizing Zika virus E-specific mouse monoclonal antibody ZV-67. Moreover, the novel EDII epitope was exclusively engaged in epitope-CDR interactions of potent neutralizing Zika virus E-specific human monoclonal antibody Z3L1. None of the linear epitopes of Zika virus NS1 were ascertained as novel based on our study criteria. Conformational epitopes were identified as novel for NS1 protein.ConclusionThis study identified Zika virus-specific novel epitopes of envelope and non-structural -1 proteins in the currently co-circulating Indian strains. Furthermore, in-silico validation through molecular docking added insight into antigen-antibody interactions, paving way for future in vitro and in vivo studies.