bluuebunny/crossref_metadata_2025_split huggingface dataset:
Curvas de dose-resposta comparativas entre os biótipos resistente e suscetível de capim-amargoso (Digitaria insularis) ao herbicida glyphosate
Authors: Reinert Camila Schorr , Prado Ana Beatriz Campos Almeida , Christoffoleti Pedro Jacob 
Published: April 2014

A utilização frequente do glyphosate em sistemas de produção da cultura do citros tem selecionado no Brasil populações resistentes de capim-amargoso (Digitaria insularis) a este herbicida, sendo importante caracterizar os níveis desta resistência para fundamentação de recomendações de medidas racionais de manejo. Sendo assim, foi conduzido um ensaio para elaboração de curvas de dose-resposta comparativa entre dois biótipos da planta daninha capim-amargoso, um resistente (R) e outro suscetível (S) ao herbicida glyphosate. O ensaio foi conduzido em casa-de-vegetação no período de fevereiro a maio de 2012, com cinco doses, do herbicida glyphosate, tendo como base a dose recomendada do herbicida, 900 g e.a. ha-1 (0,0; 450; 900; 1.800; 3.600 e 7.200 g e.a. ha-1), e a planta daninha com 3 a 4 perfilhos no momento da aplicação. Avaliou-se porcentagem de redução da biomassa seca em relação a dose 0,0 e porcentagem visual de controle, aos 14 dias após a aplicação do herbicida. O fator de resistência R/S foi de 16,66, quando baseado na redução percentual da biomassa seca, e de 20,26 quando baseado na porcentagem de controle. Sendo assim, o biótipo R tem um alto grau de resistência, maior que os já relatados na literatura, que estão em dimensões menores que 10. Alto grau de resistência pode indicar que os mecanismos de resistência ao glyphosate neste biótipo são resultantes de alteração no sítio de ação ou super expressão gênica, e não do metabolismo, como geralmente ocorre em plantas daninhas com baixos valores do fator R/S. Para determinação destes mecanismos há necessidade de novos estudos. Conclui-se também que o manejo deste biótipo deve estar fundamentado em herbicidas alternativos ao glyphosate, pois incrementos na dose de glyphosate provavelmente não são viáveis economicamente.
Acidisarcina
Authors: Belova Svetlana E. , Ivanova Anastasia A. , Dedysh Svetlana N. 
Published: July 2024

Abstract

A.ci.di.sar.ci'na. L. N. neut. adj.
acidum
, acid; L. fem. n.
sarcina,
a package, bundle; N.L. fem. n.
Acidisarcina,
acidophilic package.

Acidobacteriota / Terriglobia / Terriglobales / Acidobacteriaceae / Acidisarcina

The genus
Acidisarcina
accommodates Gram‐stain‐negative, highly polymorphic, acidophilic, psychrotolerant, chemoorganotrophic bacteria. Cells occur in pairs, sarcina‐like tetrads, or in large clusters. Young cultures may contain single cells or short chains of curved cells. In most cases, cells occur inside saccular chambers, which are made of tightly packed microfibrils of cellulose. Colonies are circular, smooth, convex, and of gummy consistency. The colony color varies from opal beige to light pink. Members of the genus are aerobes that are capable of growth under microoxic conditions. Catalase‐negative. The major phospholipid fatty acids are iso‐C
15:0
, C
16:1
ω7
c
, C
16:0
, and 13,16‐dimethyl octacosanedioic acid; the predominant quinone is menaquinone‐8. Sugars are the preferred growth substrates. Hydrolyzes various polysaccharides including xylan, esculin, laminarin, lichenan, chitin, and cellulose. The major polar lipids are phosphatidylethanolamine and phosphohexose; ornithine lipids can also be present. The genus belongs to the phylum
Acidobacteriota,
the class
Terriglobia,
the order
Terriglobales,
and family
Acidobacteriaceae
. Representatives of this genus inhabit acidic soils and peatlands and are often detected in primary soils colonized with lichens and mosses. The type species is
Acidisarcina polymorpha
.

DNA G + C content (mol%)
: 56.8 (genome sequence).

Type species
:
Acidisarcina polymorpha
Belova et al. 2022a, VL206.
A Long‐Range Planar Polymer with Efficient π‐Electron Delocalization for Superior Proton Storage
Authors: Wang Renyuan , He Jing , Yan Chao , Jing Renwei , Zhao Yue , Yang Jun , Shi Minjie , Yan Xingbin 
Published: July 2024

AbstractDue to the unique “Grotthus mechanism”, aqueous proton batteries (APBs) are promising energy devices with intrinsic safety and sustainability. Although polymers with tunable molecular structures are ideal electrode materials, their unsatisfactory proton‐storage redox behaviors hinder the practical application in APB devices. Herein, a novel planar phenazine (PPHZ) polymer with a robust and extended imine‐rich skeleton is synthesized and used for APB application for the first time. The long‐range planar configuration achieves ordered molecular stacking and reduced conformational disorder, while the high conjugation with strong π‐electron delocalization optimizes energy bandgap and electronic properties, enabling the polymer with low proton diffusion barriers, high redox activity, and superior electron affinity. As such, the PPHZ polymer as an electrode material exhibits fast, stable, and unrivaled proton‐storage redox behaviors with a large capacity of 273.3 mAh g−1 at 0.5 A g−1 (1 C) in 1 M H2SO4 electrolyte, which is the highest value among proton‐inserted electrodes in aqueous acidic electrolytes. Dynamic in situ techniques confirm the high redox reversibility upon proton uptake/removal, and the corresponding protonation pathways are elucidated by theoretical calculations. Moreover, a pouch‐type APB cell using PPHZ electrode exhibits an ultralong lifespan over 30 000 cycles, further verifying its promising application prospect.
Polyphenol‐Derived Carbonaceous Frameworks with Multiscale Porosity for High‐Power Electrochemical Applications
Authors: Kim Minjun , Jang Joon Ho , Nam Myeong Gyun , Yoo Pil J. 
Published: July 2024

AbstractWith the escalating global demand for electric vehicles and sustainable energy solutions, increasing focus is placed on developing electrochemical systems that offer fast charging and high‐power output, primarily governed by mass transport. Accordingly, porous carbons have emerged as highly promising electrochemically active or supporting materials due to expansive surface areas, tunable pore structures, and superior electrical conductivity, accelerating surface reaction. Yet, while substantial research has been devoted to crafting various porous carbons to increase specific surface areas, the optimal utilization of the surfaces remains underexplored. This review emphasizes the critical role of the fluid dynamics within multiscale porous carbonaceous electrodes, leading to substantially enhanced pore utilization in electrochemical systems. It elaborates on strategies of using sacrificial templates for incorporating meso/macropores into microporous carbon matrix, while exploiting the unique properties of polyphenol moieties such as sustainable carbons derived from biomass, inherent adhesive/cohesive interactions with template materials, and facile complexation capabilities with diverse materials, thereby enabling adaptive structural modulations. Furthermore, it explores how multiscale pore configurations influence pore‐utilization efficiency, demonstrating advantages of incorporating multiscale pores. Finally, synergistic impact on the high‐power electrochemical systems is examined, attributed to improved fluid‐dynamic behavior within the carbonaceous frameworks, providing insights for advancing next‐generation high‐power electrochemical applications.
Patterned PEDOT:PSS‐Flexible Electrode Using Electrospinning Nano‐Fiber Substrate with UV‐Induced Selective Wettability
Authors: Yu Bin‐Hai , Zhang Bin , Li Jia‐sheng , Lu Zhou , Liang Guan‐Wei , Li Zong‐tao 
Published: July 2024

AbstractWater‐soluble conductive polymer poly(3,4‐ethylenedioxythiophene)/polystyrene sulfonate (PEDOT:PSS) has a broad application prospect in the field of flexible wearable electronics, but the simple and efficient manufacture of patterned PEDOT:PSS flexible electrodes is still challenging. In this paper, a patterned PEDOT:PSS‐flexible electrode with a electrospinning nano‐fiber substrate is proposed. The electrode substrate is produced by electrospinning a hydrophobic polyvinylidene difluoride (PVDF) matrix material loaded with TiO2 UV‐induced hydrophilic‐hydrophobic conversion particles. The PEDOT:PSS flexible electrode is prepared using a simple UV‐induced selective wettability(UV‐SW) process and optimized vacuum filtration method. The method of manufacturing flexible electrodes based on patterned wetting film substrates is simple and feasible, while the electrode features high precision, good conductivity, and excellent deformation ability. The electrode has a line width error of less than 5%, an initial conductivity of 584.44 S m−1, and maintains stable conductivity under 0–180° bending and 0–30° torsion, with variation rates of only 4.9% and 2.3%, respectively. This paper presents a simple method to fabricate patterned PEDOT:PSS flexible electrode with high precision. This study provides an efficient method for the manufacturing of fibric‐based patterned flexible electrodes, this method is promising for fabric‐based wearable electronics.
Characterization of NiCas12b for In Vivo Genome Editing
Authors: Zhang Yunqian , Wei Jingjing , Wang Hongyan , Wang Yongming 
Published: July 2024

AbstractThe RNA‐guided clustered regularly interspaced short palindromic repeats (CRISPR)/Cas12b system represents the third family of CRISPR‐Cas systems that are harnessed for genome editing. However, only a few nucleases have demonstrated activity in human cells, and their in vivo therapeutic potential remains uncertain. In this study, a green fluorescent protein (GFP)‐activation assay is conducted to screen a panel of 15 Cas12b orthologs, and four of them exhibited editing activity in mammalian cells. Particularly noteworthy is the NiCas12b derived from Nitrospira sp., which recognizes a “TTN” protospacer adjacent motif (PAM) and facilitates efficient genome editing in various cell lines. Importantly, NiCas12b also exhibits a high degree of specificity, rendering it suitable for therapeutic applications. As proof of concept, the adeno‐associated virus (AAV) is employed to introduce NiCas12b to target the cholesterol regulatory gene proprotein convertase subtilisin/ kexin type 9 (Pcsk9) in the mouse liver. After 4 weeks of injections, an impressive is observed over 16.0% insertion/deletion (indel) efficiency, resulting in a significant reduction in serum cholesterol levels. NiCas12b provides a novel option for both basic research and clinical applications.
A Regenerative Coking‐resistant CO2 Hydrogenation Reactor using a Protonic Ceramic Electrolysis Cell with Thin and Robust Fuel Electrode
Authors: Miao Xiaoyun , Feng Jiangyuan , Dai Zhongqin , Zhu Xingzhi , Wen Jianjun , Zhang Liang , Ye Xiaofeng , Zhou Yucun , Wen Zhaoyin 
Published: July 2024

AbstractA CO2 hydrogenation reactor based on protonic ceramic electrolysis cells (PCECs) is one of the most promising options for the efficient and clean conversion of CO2. However, insufficient performance and durability have hindered the practical application of such CO2 hydrogenation reactors. Here, fabricates a large‐area (≈10 cm2) tubular air electrode supported PCEC (AES‐PCEC) and develop a fuel electrode regeneration strategy for efficient and durable CO2 hydrogenation. The AES‐PCEC demonstrates a CO yield of 2.88 mL min−1 at 650 °C while maintaining excellent durability for over 1100 h. The high stability of the AES‐PCEC can be attributed to the robust and thin fuel electrode structure as well as the water‐mediated carbon removal regeneration mechanism. Density functional theory calculations have confirmed the regeneration mechanism facilitated by the excellent water hydration and dissociation capability of the BaCe0.4Zr0.4Y0.1Yb0.1O3‐σ. This work offers a feasible strategy to design high‐performance and durable PCEC‐based CO2 hydrogenation reactors.
Efficient removal of emerging pollutant oxytetracycline by cost‐effective biochar–hydroxyapatite composite
Authors: Tran Quang Minh , Le Phuong Thu , Nguyen Thu Phuong , Nguyen Hong Nam , Do Thi Hai , Nguyen Trung Dung , Dinh Thi Mai Thanh 
Published: July 2024

AbstractBiochar (BC) and hydroxyapatite (HAp) are widely used in environmental remediation due to their high adsorption capacity, porous structure, large specific surface area, chemical stability, non‐toxicity, and low solubility. Combining BC and HAp is a green and effective strategy for creating new adsorbents (BCH) that have a synergistic impact on wastewater treatment. In this study, BCH composites derived from apatite ore and macadamia nut shells were synthesized by the wet impregnation method to remove oxytetracycline (OTC) from aqueous solutions. The BC‐HAp composite with a ratio of 10:1 (by weight) was the most effective material for removing OTC. The Redlich–Peterson model achieved the highest correlation coefficient among the four models tested (Freundlich, Langmuir, Temkin, and Redlich–Peterson). The maximum adsorption capacity calculated with the Langmuir isotherm was 49.59 mg g−1. It was found that the adsorption process was significantly affected by the solution pH. The bipolar form of the drug was found to be OTC±, and the adsorption was most effective in solutions with a pH of 6. The OTC adsorption dominant mechanisms on nanocomposites could be electrostatic attraction, hydrogen bonding formation, surface complexation, or ion exchange. Therefore, the BCH composite showed great potential for removing OTC pollutants in a cost‐effective, and environmentally friendly manner.
Patterns of Infliximab Biosimilar Uptake for Medicare, Medicaid, and Private Insurance from 2016 to 2022
Authors: Roberts Eric T. , Li Jing , Bansback Nick , Tseng Chien‐Wen , Shiboski Steve , Schmajuk Gabriela , Yazdany Jinoos 
Published: July 2024

ObjectiveBiosimilars have the potential to reduce spending on biologic drugs, yet uptake has been slower than anticipated. We investigated how successive introductions of infliximab biosimilars influenced their adoption by major US insurance providers.MethodsData came from the Rheumatology Informatics System for Effectiveness, a national registry with electronic health records from more than 1,100 US rheumatologists. All infliximab administrations (bio‐originator or biosimilar) to patients aged ≥18 years from April 2016 to September 2022 were included. We used an interrupted time series to model the effect of each infliximab biosimilar release (infliximab‐dyyb, November 2016; infliximab‐adba, July 2017; and infliximab‐axxq, July 2020) on uptake across Medicare, Medicaid, and private insurers.ResultsWith the first and second biosimilar releases, biosimilar uptake rose slowly, with average annual increases of ≤5% from 2016 to June 2020 (Medicare 3.2%, Medicaid 5.2%, and private insurance 1.8%). With the third biosimilar release in July 2020, the average annual increase reached 13% for Medicaid and 16.4% for private insurance but remained low for Medicare (5.6%). By September 2022, uptake was higher for Medicaid (43.8%) and private insurance (38.5%) than for Medicare (24%).ConclusionOur results have two key findings for policy makers. First, our results suggest that one or two biosimilars may not generate enough competition to speed adoption rates for biosimilars. Second, Medicare, which covers most patients receiving biologics nationally, had slow adoption rates even after the third biosimilar was introduced. Policy levers to speed adoption among Medicare beneficiaries are needed.
Two Different Chiral Groups Based Thermally Activated Delayed Fluorescence Materials for Circularly Polarized OLEDs
Authors: Liang Jia‐Qi , Hu Jia‐Jun , Huo Zhong‐Zhong , Yan Zhi‐Ping , Yuan Li , Zhong Xiao‐Sheng , Wei Yi , Song Shi‐Quan , Liu Qi‐Ming , Song You , Zheng You‐Xuan 
Published: July 2024

AbstractCircularly polarized organic light‐emitting diodes (CP‐OLEDs) hold significant promise for applications in 3D displays due to the ability to generate circularly polarized luminescence (CPL) directly. In this study, two pairs of circularly polarized thermally activated delayed fluorescence (CP‐TADF) enantiomers, named RR/SS‐ONCN and RS/SR‐ONCN, were synthesized by integrating two distinct chiral groups into the dicyanobenzene unit. The RR/SS‐ONCN and RS/SR‐ONCN enantiomers show CPL properties with dissymmetry photoluminescence factors (|gPL|) of 1.3×10−3 and 2.0×10−3 in doped films, respectively. Notably, RR/SS‐ONCN exhibit higher |gPL| values than that of RS/SR‐ONCN, especially in doped films, indicating that when the configurations of the two chiral groups are identical, the |gPL| value of the CP‐TADF materials can be enhanced, demonstrating a certain stacking effect. Moreover, the corresponding CP‐OLEDs demonstrate good performances, achieving maximum external quantum efficiencies of up to 21.9 % and notable CP electroluminescence with |gEL| factors of up to 1.0×10−3.
Utilization of citrus, date, and jujube substrates for anaerobic digestion processes
Authors: Chubur Viktoriia , Hasan Ghaith , Kára Jaroslav , Hanzlíková Irena , Chernysh Yelizaveta , Sedláček Jan , Wang Jian , Roubík Hynek 
Published: July 2024

AbstractThis research explores the potential for generating biogas and clean energy by processing organic waste, a process that can become a sustainable solution to Syria's energy needs. Focusing on agricultural residues generated from citrus fruit orange, date, and jujube cultivation in Syria, this study evaluates the potential for anaerobic digestion of these residues for biogas production. It highlights the influence of substrate composition and the optimization of fermentation processes on biogas and methane production. The study focuses on evaluating the anaerobic digestion process by examining various dosages ranging from 20% to 50% dry matter for citrus orange waste, and different types of substrate with a fixed ratio of 20% substrate dry matter. It specifically discusses the factors influencing the inhibitory effect of anaerobic digestion, giving particular consideration to orange waste, a significant byproduct of the citrus industry. The biogas produced maintained a stable methane content when a citrus‐to‐inoculum ratio of 30:70 was used. Jujube waste, characterized by a composition rich in cellulose and hemicellulose, exhibited a higher potential for biogas and methane generation among the fruit waste investigated, particularly when combined with the inoculum in a 20:80 ratio. The research findings underscore the potential of using Syrian agricultural residues, including orange citrus peel, date, and jujube fruit, for the production of biogas through anaerobic digestion.
Repurposing Antiviral Drugs as Potential Anti‐EGFR Agents in NSCLC: A Structure‐Based Screening and Molecular Dynamics Analysis
Authors: Adegboyega Fikayo N. , Anifowose Lateef O. , Hammad Sherif F. , Ghazy Mohamed A. 
Published: July 2024

AbstractOne of the problems resulting from recurrent hyperactivated or mutant epidermal growth factor receptors (EGFR) in non‐small cell lung cancer (NSCLC) is therapeutic resistance. Consequently, this leads to increased expression of oncogenic proteins and reduces the efficacy of EGFR tyrosine kinase inhibitors (TKIs). This study assessed antiviral drug efficacy as potential anti‐EGFR agents for NSCLC. We used structure‐based virtual screening to evaluate 66 antiviral drugs thoroughly. The top 6 antiviral drugs exhibiting impressive binding energies (i. e. surpassing a threshold of −8.5 kcal mol−1) were identified. Subsequent bioactivity analysis and ADMET profiling were performed to select the most promising candidates, followed by a molecular dynamic simulation. Among the selected antiviral regimens, dolutegravir demonstrated the highest docking score (−9.8 kcal mol−1), followed by rilpivirine and ensitrelvir, surpassing other candidates and our reference EGFR TKI. Further molecular dynamics simulations revealed promising dynamic interactions of dolutegravir, ensitrelvir, and rilpivirine with the EGFR target as compared with afatinib. Our findings highlight the repositioning potential of antiviral drugs for anti‐EGFR drug discovery, supported by their robust docking scores, ADMET profiles, dynamic interactions, and binding free energies. The results open up new avenues for advanced NSCLC therapy. Further in vitro investigations are warranted to evaluate their efficacy and safety.
In‐Vitro Cytotoxic and Anti‐Inflammatory Potential of Asparagus Densiflorus Meyeri and its Phytochemical Investigation
Authors: Sobhy Yasmin , Mahgoub Shahenda , Abo‐zeid Yasmin , Mina Suzan A. , Mady Mohamed S. 
Published: July 2024

AbstractGenus Asparagus is well known for its pharmacological activities and ethnopharmacological applications. In folk medicine, it is used in the management of several diseases such as diabetes, inflammations, and rheumatism. This work aimed to investigate the potential of Asparagus densiflorus meyeri root & aerial parts extracts as cytotoxic and anti‐inflammatory and the investigation of their chemical profile. GC analysis & Folin‐Ciocalteu and gravimetric methods were used respectively to estimate the lipoidal, phenolic, and saponin contents. MTT assay was conducted using two cell lines (MCF‐7 & HepG2) to investigate the cytotoxic and anti‐inflammatory activity using TNF‐α stimulated MCF‐7 cells through monitoring the level of nitric oxide release and NF‐κB gene expression. Preliminary phytochemical investigation indicated that both extracted parts are equally rich in saponins, flavonoids, carbohydrates and/or glycosides, and sterols and/or triterpenes. Palmitic acid and β sitosterol represented the major saturated fatty acids and sterol, respectively. A significant cytotoxic activity against MCF‐7 cells was recorded for DCM extract (IC50 26.13 μg/ml). All tested extracts showed a significant decrease in NO release and NF‐κB gene expression thus it possesses a potential anti‐inflammatory activity. A. densiflorus meyeri is considered a good candidate as a food supplement for protection from malignancy.
A Homogeneous Nickel Catalyst for Reductive Amination of γ‐Keto Acids using Hydrogen
Authors: Chakrabortty Soumyadeep , Moritz Jan‐Ole , Kallmeier Fabian , Neumann Helfried , Tin Sergey , Beller Matthias , de Vries Johannes G. 
Published: July 2024

AbstractThe reductive amination of levulinic and 2‐acetyl benzoic acids with hydrogen and various amines proceeds efficiently in the presence of a homogeneous Ni/triphos‐catalyst. The reaction rate of the overall process is significantly enhanced using 3,3,3‐trifluoroethanol (TFE) as solvent. The optimized synthetic protocol allows for a straightforward access of >20 examples of N‐functionalized pyrrolidinones in high yields (75 % and >99 %). Upscaling to 10 mmol‐scale is demonstrated and mechanistic in situ studies revealed the presence of alkoxy‐ and hydroxylactams as crucial intermediates.
Photocatalytic Reductive Azaarenylation of Cyclopropanes via Consecutive Photo‐induced Electron Transfer: A Facile Route to α‐Quaternary Azaarenes†
Authors: Sun Gaolei , Wei Wenhui , Zhao Xiaowei , Qiao Baokun , Jiang Zhiyong 
Published: July 2024

Comprehensive Summaryα‐Azaarene quaternary carbon centers are prevalent in drug molecules, making the development of efficient synthetic approaches of great interest. Herein, we describe an unprecedented method for constructing α‐all‐carbon quaternary carbon‐centered azaarenes by employing photocatalytic reductive coupling of various 2,2‐disubstituted cycloproarylketones with readily available cyanoazaarenes. The reaction proceeds with high efficiency, displaying excellent compatibility with various functional groups and demonstrating high chemo‐ and regioselectivity. Mechanistic investigations suggest that consecutive photo‐induced electron transfer (ConPET) plays a crucial role in the formation of photocatalyst with greater reducing capability, ultimately enabling the direct reductive conversion of unreactive π‐bonds under mild and transition‐metal‐free conditions.