bluuebunny/crossref_metadata_2025_split huggingface dataset:
Contribution of a mutational hot spot to hemoglobin adaptation in high-altitude Andean house wrens
Authors: Galen Spencer C. , Natarajan Chandrasekhar , Moriyama Hideaki , Weber Roy E. , Fago Angela , Benham Phred M. , Chavez Andrea N. , Cheviron Zachary A. , Storz Jay F. , Witt Christopher C. 
Published: October 2015

SignificanceWithin a given gene, there may be many possible mutations that are capable of producing a particular change in phenotype. However, if some sites have especially high rates of mutation to function-altering alleles, then such mutations may make disproportionate contributions to phenotypic evolution. We report the discovery that a point mutation at a highly mutable site in the β-globin gene of Andean house wrens has produced a physiologically important change in the oxygenation properties of hemoglobin (Hb). The mutant allele that confers an increased Hb–O2affinity is present at an unusually high frequency at high altitude. These findings suggest that site-specific variation in mutation rate may exert a strong influence on the genetic basis of phenotypic evolution.
Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II/III spinal muscular atrophy
Authors: Bogdanik Laurent P. , Osborne Melissa A. , Davis Crystal , Martin Whitney P. , Austin Andrew , Rigo Frank , Bennett C. Frank , Lutz Cathleen M. 
Published: October 2015

Significance
Spinal muscular atrophy (SMA) is one of the most frequent infantile genetic diseases and impairs breathing and locomotion. Promoting RNA splicing of one of the genes involved in SMA leads to spectacular improvements in laboratory models. Splicing modulators such as antisense oligonucleotides (ASOs) therefore come to the forefront of therapeutic candidates. However, timing of delivery and route of administration still need to be optimized. Do ASOs have to be delivered into the central nervous system, and are ASOs still efficient if administered late after disease onset? In a new mouse model for SMA, we show that ASOs were efficacious when delivered outside of the spinal cord and late after the onset of the symptoms of the animals.
Successful arrest of photoreceptor and vision loss expands the therapeutic window of retinal gene therapy to later stages of disease
Authors: Beltran William A. , Cideciyan Artur V. , Iwabe Simone , Swider Malgorzata , Kosyk Mychajlo S. , McDaid Kendra , Martynyuk Inna , Ying Gui-Shuang , Shaffer James , Deng Wen-Tao , Boye Sanford L. , Lewin Alfred S. , Hauswirth William W. , Jacobson Samuel G. , Aguirre Gustavo D. 
Published: October 2015

Significance
Corrective gene therapies for inherited retinal degenerations are being developed with the expectation that even patients in later stages of the disease will benefit from such intervention. Evidence in animal models for a rescue after the onset of photoreceptor loss is scarce, and recent results from patients enrolled in two of the gene therapy clinical trials for a congenital form of blindness (RPE65-LCA) show that, despite transient improvement in visual function, photoreceptor cell death remains unabated. Here we show in a canine model for a common and severe form of X-linked retinal degeneration that gene therapy successfully stops photoreceptor cell death, improves the structure of retinal cells, and prevents vision loss for more than 2 y.
Elevated levels of diesel range organic compounds in groundwater near Marcellus gas operations are derived from surface activities
Authors: Drollette Brian D. , Hoelzer Kathrin , Warner Nathaniel R. , Darrah Thomas H. , Karatum Osman , O’Connor Megan P. , Nelson Robert K. , Fernandez Loretta A. , Reddy Christopher M. , Vengosh Avner , Jackson Robert B. , Elsner Martin , Plata Desiree L. 
Published: October 2015

Significance
Organic compounds found in drinking water aquifers above the Marcellus Shale and other shale plays could reflect natural geologic transport processes or contamination from anthropogenic activities, including enhanced natural gas production. Using analyses of organic compounds coupled with inorganic geochemical fingerprinting, estimates of groundwater residence time, and geospatial analyses of shale gas wells and disclosed safety violations, we determined that the dominant source of organic compounds to shallow aquifers was consistent with surface spills of disclosed chemical additives. There was no evidence of association with deeper brines or long-range migration of these compounds to the shallow aquifers. Encouragingly, drinking water sources affected by disclosed surface spills could be targeted for treatment and monitoring to protect public health.
Noninvasive monitoring of infection and rejection after lung transplantation
Authors: De Vlaminck Iwijn , Martin Lance , Kertesz Michael , Patel Kapil , Kowarsky Mark , Strehl Calvin , Cohen Garrett , Luikart Helen , Neff Norma F. , Okamoto Jennifer , Nicolls Mark R. , Cornfield David , Weill David , Valantine Hannah , Khush Kiran K. , Quake Stephen R. 
Published: October 2015

Significance
Over 3,500 patients receive life-saving lung transplants every year. Nonetheless, complications due to infection and rejection occur frequently and undermine the long-term benefits of lung transplantation. Although clinicians strive to carefully monitor patients, diagnostic options are often limited. Rejection monitoring currently relies on invasive tissue biopsies, and tests of infection are predominately limited to testing one pathogen at a time. This manuscript describes a noninvasive assay based on sequencing of circulating cell-free DNA that simultaneously enables diagnosis of rejection and broad screening of infections.
Theoretical and methodological advances in cluster research
Authors: Reve Torger , Sasson Amir 
Published: October 2015

Purpose
– This paper aims to assess the dissemination of cluster ideas advanced in the “Competitive Advantage of Nations” and three subsequent national studies and the reasons for their substantial public policy impact in Norway.

Design/methodology/approach
– The paper presents the theoretical and methodological novelties of each of the national studies, the inclusive study-organizing principle used and public policy impact.

Findings
– The papers finds that the dissemination of cluster thinking and the development of a successful cluster-based industrial policy in Norway is largely a function of the nature and extent of the cluster research efforts that took place in Norway. The national cluster research projects mobilized all the key industrial and governmental actors in a very effective way, making studies with both rigor and relevance. Due to advanced and demanding policy makers, the studies also evolved in terms of the theoretical models and methodologies used.

Originality/value
– The paper contributes by illuminating the direct and indirect impact of the “Competitive Advantage of Nations” on both academic endeavors and public policies in Norway and by explicating how studies that make it possible for academics and practitioners to work in tandem substantially affect public policy.
Group-based mindfulness-informed psychological first aid after Typhoon Haiyan
Authors: Hechanova Regina M. , Ramos Pia Anna P. , Waelde Lynn 
Published: October 2015

Purpose
– The purpose of this paper is to develop and evaluate a culturally sensitive and mindfulness informed psychological first aid (PFA) intervention for use with disaster workers in the Philippines intended to increase disaster knowledge and disaster coping self-efficacy.

Design/methodology/approach
– The study used a non-experimental, pre-test, post-test design. Measures of disaster knowledge and disaster coping self-efficacy were measured before and after the PFA intervention.

Findings
– Paired sample t-tests revealed significant pre/post-increases in knowledge about disaster reactions and disaster coping self-efficacy. Workshop evaluations indicated that the following proportions of participants rated these workshop components as the most useful: mindfulness, information about disaster reactions, small group sharing, information about coping, and the open space activity.

Research limitations/implications
– As in many disaster studies, it was not possible to include a randomized control group in the design. Another limitation was that only pre- and post-intervention data were collected. Future research should include longer-term follow-ups with participants to assess whether the benefits of the intervention are maintained over time. Future research may wish to address the limitations of the study including the lack of a control group and obtaining follow-up data to enable more robust conclusions.

Practical implications
– These results indicate how the use of a group-based intervention may be helpful especially in a collectivist culture. At the same time, acknowledging cultural values such as spirituality is an important component to providing psychosocial support for survivors. Mindfulness was found useful both as an initial calming activity as well as a means for helping survivors manage their stress reactions. Finally, the utilization of an open space activity can also be a helpful problem-solving mechanism when done in intact groups, as it enhances not just self-efficacy but also community efficacy among survivors.

Originality/value
– The study contributes to the dearth of knowledge on the use of PFA when used in a group, collective, and developing country setting.
The voice of the customer in the design of organized retail stores
Authors: Prakash Gyan , Vohra Abhinav , Sahney Sangeeta 
Published: October 2015

Subject area
Marketing, retail.

Study level/applicability
The case study is specific to the marketing demographics of Indian shoppers with respect to organized retail stores, and therefore, the inter-relationships between various design elements and the relative importance of certain parameters discussed in the text may not follow the same pattern elsewhere in the world.

Case overview
The case emulates the real-life situation of an organized retail store, Super Mart, to understand the inculcation of voice of the customer in the design of organized retail stores in India. It gives insights about factors which influence the shopping intent of customers while giving information about the inter-relationships among various design characteristics. It also gives an idea about inter-dependence between design characteristics and customer requirements. This is followed by certain questions, the responses to which can be interpreted from the text and the data provided therein.

Expected learning outcomes
The case aims to educate its audience about the following aspects of organized retail business: factors influencing offline shopping intent of customers; relative order of importance of customer requirements with respect to organized retail stores; inter-relationships between various design elements; and future trends in the organized retail space. Such a knowledge would help hone the skills of the next generation of business leaders in the retail space.

Supplementary materials
Teaching notes are available for educators only. Please contact your library to gain login details or email support@emeraldinsight.com to request teaching notes.
Creative climate and organisational resilience: the mediating role of innovation
Authors: Mafabi Samuel , Munene John C. , Ahiauzu Augustine 
Published: October 2015

Purpose– This study aims to investigate the mediation role of innovation between creative climate and organisational resilience.Design/methodology/approach– The study used a cross-sectional design to collect data about the study variables from parastatal managers using self-administered questionnaires. Hierarchical regression and Medigraph were used to test hypotheses.Findings– Creative climate has a significant association with innovation and organisational resilience. Innovation partially mediates the effect of creative climate on organisational resilience.Research limitations/implications– The sample size was small involving only parastatals. The results may be different in an expanded public sector. The study was cross-sectional that is limited in examining long-term effects of creative climate and innovation on organisational resilience. Therefore, a longitudinal study design is proposed for future research.Practical implications– Managers in parastatals need to provide a conducive creative climate that promotes innovations for organisational resilience.Originality/value– The study provides empirical evidence on the mediation role of innovation in the relationship between creative climate and organisational resilience in a public sector. The evidence shows the contribution of innovation in striving for organisational resilience based on the creative climate.
Motivations for customer engagement in online co-innovation communities (OCCs)
Authors: Zhang Tingting (Christina) , Kandampully Jay , Bilgihan Anil 
Published: October 2015

Purpose
– This paper aims to propose an extended model to examine these motivations. As technology-led changes have revolutionized the marketplace, researchers and practitioners have grown keen to understand customers’ motivations for engaging in co-innovation in online communities.

Design/methodology/approach
– The research model is based on a review of previous literature and relevant business practices.

Findings
– The proposed conceptual model can be used to test empirically and explicate customers’ attitude towards engagement in co-innovation communities in the hospitality industry. Three major motivations drive customer engagement in online co-innovation communities (OCCs): brand equity, sense of community and monetary incentive. Customers’ prior experience with co-innovation projects also moderates the effects of the three motivations on customers’ attitude towards engagement in OCCs.

Practical implications
– The proposed model highlights the importance of engaging customers through OCCs to create service innovations. These OCCs advance customers’ active participation in the firm’s co-creation and co-innovation process. Leading service firms already rely on online brand communities to stay on the cutting edge. Co-creation represents a unique, strategic partnership between the firm and the customer that can enhance both the customer experience and the firm’s innovativeness.

Originality/value
– This study provides an initial exploration of the key components of the co-innovation of service through online communities in the hospitality industry.
Crowdsourcing innovative service ideas
Authors: Duverger Philippe 
Published: October 2015

Purpose– The purpose of this paper is to demonstrate how negatively worded innovative ideas can be rejected during a crowdsourcing event sponsored by a service firm via an online forum. The goal of an ideation forum is to collect user-generated content in the form of ideas for new products or services. An ideation forum attempts to clarify the “fuzziness” on the front-end of new product development.Design/methodology/approach– A 2 × 2 (satisfied/dissatisfied customers and negatively/positively worded ideas) experiment replicates the effect of mood-incongruent interactions within ideation forums and measures the likelihood for an idea to be buried or selected on the basis of its merit rather than its negative/positive wording.Findings– The results demonstrate that mood-incongruent interactions have different effects on different groups of participating customers. Negatively worded innovative ideas are rated lower by satisfied customers, despite their superior merit.Research limitations/implications– The nature of the experiment shows a high validity, but lacks in reliability. Thus, future research should attempt to replicate this experiment on a larger scale and across different industries.Practical implications– In an open forum where thousands of customers can give a thumbs’ up or down to an idea, merit should prevail over mood-congruency. If the crowdsourcing mechanism cannot be trusted, it puts the burden back on the firm’s review team to promote or review any downgraded innovative idea, which ends up being counterproductive.Originality/value– These findings shed light on the hidden aspect of crowdsourcing when the aim is to find unique, if not radical, ideas for services. Thus, hoteliers and other hospitality and tourism managers should use these findings to design better ideation forums.
Operationalizing cultural political economy: towards critical grounded theory
Authors: Belfrage Claes Axel , Hauf Felix 
Published: October 2015

Purpose– The purpose of this paper is to take conceptual and methodological steps towards the elaboration of the critical grounded theory (CGT) method.Design/methodology/approach– Starting from conceptual issues with mapping everyday discourses and practices in their broader societal context in organisational ethnography, cultural political economy (CPE) is proposed as a suitable theoretical framework for integrating the cultural dimension of discourses and imaginaries into political-economic analyses of organisation and management. The CGT method is introduced for empirical operationalisation.Findings– Grounded theory tools for working with ethnographic data can be employed within critical approaches such as CPE although they originate from positivist social science. The need to combine ethnographic fieldwork with substantial theoretical work and/or critical discourse analysis may be met by CGT, which affords the ethnographic strengths of grounded theory without, however, bracketing the critical-theoretical insights of CPE.Research limitations/implications– The usefulness of CGT has been tentatively tested, but requires thorough meta-theoretical and methodological development, which is what is undertaken here.Social implications– CGT expects and takes account of the social implications of its employment in the field.Originality/value– First steps towards a new critical method for organisation and management studies are taken. Although originating from concern with CPE, the CGT method may appeal to a wider audience of critical scholars across the social sciences.
Balancing differentiated interests and conceptualizations in environmental management
Authors: Sjölander-Lindqvist Annelie 
Published: October 2015

Purpose– The purpose of this paper is to explore the everyday practices and routines undertaken by an authority to support internal coordination and deal with sector-specific interests and conflicting goals, and how exclusive interests and objectives in policy work are construed, understood, and negotiated in practice.Design/methodology/approach– An institutional ethnographic approach was adopted to investigate how policy-formulated goals, bureaucratic aims, and rules establish a frame for action procedures and alternatives available for agency-level collaboration.Findings– The results of this study reveal how compromise and agreement may be difficult to achieve in practice since each concerned administrative unit has its own sets of criteria concerning what constitutes valid or valuable knowledge of aspects relating to river restoration. The study illustrates how lack of knowledge affects collaboration, how the policy process is informed by sector-specific rules and norms for organizational conduct, and how the professions in their discussions and interaction concerning the issue of river restoration uphold, demarcate, and negotiate what knowledge and interests should take centre stage in the decision-making process.Originality/value– The paper contributes to policy anthropology literature and highlights how the policy process is informed politically and regulatorily but is also guided by sector-specific norms, values, and differently construed ideas of temporality and heritage. In this case, policy work exposes contrasting ideas of the past, present, and future, and mobilize diverse conceptual models and structural arrangements that are continually performed and contested in everyday policy work.
Causality as individual essence: its bearing on synchronicity
Authors: Tougas Cecile T. 
Published: October 2015

AbstractCausality, time, and number are subjectively lived realities and need to be noticed as such. Fundamental to the wide range of living experience, they are also basic to scientific knowing. In this article I examine causality in relation to an article on synchronicity by Harald Atmanspacher and Wolfgang Fach. My examination is neither scientific nor metaphysical, but rather phenomenological, as it is a clarification of form as individual essence of a thing. This non‐material form of an individual thing in the widest sense of the word ‘thing’ was rejected and so lost during modern seventeenth‐century science but, renewed now, can help describe synchronicity.A commentary by William Willeford follows.
Levels of unconsciousness and their formal structure
Authors: Atmanspacher Harald 
Published: October 2015

AbstractThis brief essay replies to Carvalho's exposition of a formal approach to the concept of the unconscious which is originally due to Ignacio Matte Blanco (1908–1995), a psychoanalyst from Chile. It's a challenge – first because I have been largely unfamiliar with the details of Matte Blanco's approach, and second because the space available for this reply does not allow me to be as precise as Carvalho's essay no doubt deserves. I will start with some remarks about how I see Matte Blanco's system from a mathematical perspective and then try to relate it to some of the core features of Pauli's and Jung's thinking. I will conclude with a tentative proposal of how Matte Blanco's strata between full consciousness and most undifferentiated unconscious can be related to the tension between ontic and epistemic accounts.
Food and Dietary Supplement Package Labeling—Guidance from FDA's Warning Letters and Title 21 of the Code of Federal Regulations
Authors: Brody Tom 
Published: October 2015

AbstractPackage labels for foods and dietary supplements must conform with Title 21 of the Code of Federal Regulations. This review provides guidance for the content and format of labels, including for the Nutrient Facts panel and Supplement Facts panel, and for drafting structure/function claims, health claims, and nutrient content claims. Also provided is guidance on how to refrain from drafting disease claims. Inappropriate disease claims on a food or dietary supplement compels FDA to review the product as a drug. Disease claims is the most common source of complaint in FDA's warning letters. This review makes use of all of FDA's warning letters that were published over a 14‐y span (2002to 2015). This is the first comprehensive review on package labels to make use of FDA's warning letters as a source document.
Granulocyte and Monocyte Adsorption Apheresis for Refractory Skin Diseases due to Activated Neutrophils, Psoriasis, and Associated Arthropathy
Authors: Sakanoue Masanao , Takeda Koichiro , Kawai Kazuhiro , Kanekura Takuro 
Published: October 2015

AbstractGranulocyte and monocyte adsorption apheresis (GMA), an extracorporeal apheresis instrument whose column contains cellulose acetate (CA) beads, is designed to remove activated granulocytes and monocytes. We previously demonstrated that GMA was useful for treating neutrophilic dermatoses and associated arthropathy as it adsorbs Mac‐1 (CD11b/CD18)‐expressing neutrophils to the CA beads by the binding of complement component (iC3b) and CD11b expressed on activated neutrophils. The objective of this study is to further assess the clinical effectiveness of GMA in the treatment of neutrophilic dermatoses and associated arthropathy. The effect of GMA for skin lesions and joint lesions was assessed in 44 and 23 patients, respectively. Mac‐1 expression on peripheral neutrophils was measured by flow cytometry. Skin lesions and arthropathy improved in 39 of 44 patients (88.6%) and 22 of 23 (95.6%), respectively. Mac‐1 (CD11b/CD18) expression on the peripheral neutrophils, 27.1 ± 6.66 MFI (mean fluorescence intensity) before treatment, was reduced to 17.9 ± 3.02 MFI by GMA (P < 0.05). Clinical effectiveness of GMA for the treatment of intractable neutrophilic dermatoses and associated arthropathy was further confirmed.