bluuebunny/crossref_metadata_2025_split huggingface dataset:
Influence of Health Insurance Status on the Timing of Surgery and Treatment of Bucket-Handle Meniscus Tears
Authors: Sood Amit , Gonzalez-Lomas Guillem , Gehrmann Robin 
Published: May 2015

Background Lack of insurance has been shown to lead to delays in seeking care as well as fewer preventive medicine visits and poorer overall health status. Purpose To investigate the effects of insurance status on the timing and treatment of patients with bucket-handle meniscus tears. Study Design Cohort study; Level of evidence, 3. Methods Charts from 2004 to 2013 were retrospectively reviewed for patients diagnosed with bucket-handle meniscus tears. Patients were divided into 2 groups: insured or underinsured. The insured group included patients with commercial insurance or Medicare. The underinsured group included patients with Medicaid or Charity Care. Time intervals were categorized as <6 weeks or ≥6 weeks. Results A total of 52 patients were included in this study: 15 (29%) insured and 37 (71%) underinsured. Underinsured patients experienced delays in initial presentation to an orthopaedic surgeon ( P = .004), time from magnetic resonance imaging to surgery ( P = .01), and time from injury to surgery ( P = .007). Repair rates were 40% and 38% ( P > .999) for the insured and underinsured, respectively. Repair rates for <6 weeks from injury to surgery were 75% for insured ( P = .007) and 100% for underinsured patients ( P = .001). Repair rates for ≥6 weeks from injury to surgery were 0% for insured and 30% for underinsured patients. Overall, patients with an injury-to-surgery time of <6 weeks had a significantly higher repair rate (87%) than those managed >6 weeks (19%) ( P < .001). Conclusion Underinsured patients experience significant delays in time to presentation and overall time to surgery. However, the overall repair rate between the insured and underinsured is similar. Regardless of insurance status, patients undergoing arthroscopy within 6 weeks of injury have a significantly higher repair rate than those after 6 weeks. Clinical Relevance Patients undergoing arthroscopy within 6 weeks of injury have a significantly higher repair rate than those after 6 weeks.
Phosphatase Wip1 controls antigen-independent B-cell development in a p53-dependent manner
Authors: Yi Weiwei , Hu Xuelian , Chen Zhiyang , Liu Leiming , Tian Yuan , Chen Hui , Cong Yu-sheng , Yang Fan , Zhang Lianfeng , Rudolph Karl Lenhard , Zhang Zhixin , Zhao Yong , Ju Zhenyu 
Published: May 2015

Key PointsWip1 controls antigen-independent B-cell development in the bone marrow via a p53-dependent pathway. Wip1 is essential to prevent an aging-related decline in B-cell development.
Low parental support in late adolescence predicts obesity in young adulthood; Gender differences in a 12-year cohort of African Americans
Authors: Assari Shervin , Caldwell Cleopatra Howard , Zimmerman Marc A. 
Published: May 2015

AbstractBackgroundMost studies that have investigated the link between parenting behaviors and risk of obesity among offsprings have mostly used a cross-sectional design, enrolled Caucasian samples, focused on childhood obesity, and covered aspects of parenting behaviors that directly influence energy balance and food intake of the children. Thus, more longitudinal research is needed on how more general aspects of parenting influence obesity in young ethnic minority adults. The current longitudinal study aimed to test if baseline parental support predicts change in body mass index (BMI) of African Americans, and if this prediction varies based on gender of offspring.MethodsThe current study followed 227 young African American adults (109 male and 118 female) for 12 years from year 2000 (mean age 20) to year 2012 (mean age 32). All participants were enrolled from a disadvantaged urban area in the Midwest of the United States. Baseline demographics (age, gender), socio-economics (family structure, and parental employment), psychological symptoms (anxiety and depression), general parental support (maternal support, and paternal support) were measured. BMI was measured at baseline and at follow up. We used gender-specific linear regressions to test the predictive role of baseline paternal and maternal support (year 2000) on change in BMI (from 2000 to 2012).ResultsRegression analysis showed that among female African American young adults, high baseline maternal support was predictive of a lower increase in BMI from 2000 to 2012. The association remained significant while all covariates were in the model. We could not find such an association for male African American young adults.ConclusionHigh maternal support appears to be protective against increases in BMI among African American female young adults. As parental support is a modifiable factor within available evidence-based interventions that enhance parenting, it should be included in obesity prevention programs for African American women. Policies and programs should support African American mothers in disadvantaged neighborhoods to enable them to provide high levels of parental support for their young adult daughters. Future research should test the efficacy of such programs and policies for reducing obesity among African American women.
Outdoor occupational environments and heat stress in IRAN
Authors: Heidari Hamidreza , Golbabaei Farideh , Shamsipour Aliakbar , Rahimi Forushani Abbas , Gaeini Abbasali 
Published: May 2015

Abstract

Background
The present study aimed at demonstrating the heat stress situation (distribution and intensity) based on a standard and common heat stress index, Wet Bulb Globe Temperature (WBGT), during hot seasons and interpret the obtained results considering global warming and rising temperature in different parts of the country based on climate changes studied in Iran.

Methods
Heat stress assessment was done using WBGT index. Environmental parameters were measured simultaneously in the early, middle and end of shift work. The personal parameters including cloth thermal insulation and metabolic rate of 242 participants from 9 climatic categories were recorded for estimating effective WBGT (measured WBGT plus cloth adjustment factor as well as metabolic rate effect). The values of the indicator were categorized in the statistical software media and then linked to the climatic zoning of the data in the GIS information layers, in which, WBGT values relating to selected stations were given generalization to similar climatic regionalization.

Results
The obtained results showed that in the summer about 60 % and more than 75 % of the measurements relating to 12 pm and 3 pm, respectively, were in heat stress situations (i.e. the average amount of heat stress index was higher than 28 °C). These values were found to be about 20–25 % in the spring. Moreover, only in the early hours of shift work in spring could safe conditions be seen throughout the country. This situation gradually decreased in the middle of the day hours and was replaced by the warning status and stress. And finally, in the final hours of shift work thermal stresses reached their peaks. These conditions for the summer were worse.

Conclusions
Regarding several studies related to climate change in Iran and the results of present study, heat stress, especially in the central and southern parts of Iran, can be exacerbated in the decades to come if climate change and rising temperature occurs. Therefore, paying attention to this critical issue and adopting macro-management policies and programs in the field of workplace health is essential.
Predictors of round window accessibility for adult cochlear implantation based on pre-operative CT scan: A prospective observational study
Authors: Park Edward , Amoodi Hosam , Kuthubutheen Jafri , Chen Joseph M. , Nedzelski Julian M. , Lin Vincent Y. W. 
Published: May 2015

Background Cochlear implantation has become a mainstream treatment option for patients with severe to profound sensorineural hearing loss. During cochlear implant, there are key surgical steps which are influenced by anatomical variations between each patient. The aim of this study is to determine if there are potential predictors of difficulties that may be encountered during the cortical mastoidectomy, facial recess approach and round window access in cochlear implant surgery based upon pre-operative temporal bone CT scan. Methods Fifty seven patients undergoing unilateral cochlear implantation were analyzed. Difficulty with 1) cortical mastoidectomy, 2) facial recess approach, and 3) round window access were scored intra-operatively by the surgeon in a blinded fashion (1 = “easy”, 2 = “moderate”, 3 = “difficult”). Pre-operative temporal bone CT scans were analyzed for 1) degree of mastoid aeration; 2) location of the sigmoid sinus; 3) height of the tegmen; 4) the presence of air cells in the facial recess, and 5) degree of round window bony overhang. Results Poor mastoid aeration and lower tegmen position, but not the location of sigmoid sinus, are associated with greater difficulty with the cortical mastoidectomy. Presence of an air cell around the facial nerve was predictive of easier facial recess access. However, the degree of round window bony overhang was not predictive of difficulty associated with round window access. Conclusion Certain parameters on the pre-operative temporal bone CT scan may be useful in predicting potential difficulties encountered during the key steps involved in cochlear implant surgery.
Impact of Radiotherapy When Added to Androgen-Deprivation Therapy for Locally Advanced Prostate Cancer: Long-Term Quality-of-Life Outcomes From the NCIC CTG PR3/MRC PR07 Randomized Trial
Authors: Brundage Michael , Sydes Matthew R. , Parulekar Wendy R. , Warde Padraig , Cowan Richard , Bezjak Andrea , Kirkbride Peter , Parliament Matthew , Moynihan Clare , Bahary Jean-Paul , Parmar Mahesh K.B. , Sanders Karen , Chen Bingshu E. , Mason Malcolm D. 
Published: May 2015

Purpose The NCIC CTG PR3/MRC PR07 randomized phase III trial compared androgen-deprivation therapy (ADT) alone versus ADT with radiotherapy (RT) for patients with locally advanced prostate cancer. This article reports the health-related quality-of-life (HRQOL) outcomes of this trial. Patients and Methods A total of 1,205 patients were randomly allocated to either ADT alone or ADT with RT. HRQOL was assessed at baseline and every 6 months thereafter using the European Organisation for Research and Treatment of Cancer Core Questionnaire and a prostate cancer–specific checklist or the Functional Assessment of Cancer Therapy–Prostate questionnaire. Mean changes from baseline scores for five function domains and nine symptom domains were analyzed as those most relevant to ADT and RT. The proportions of patients with improved, stable, or worsened HRQOL scores according to instrument-specific minimal important differences were calculated. Results Baseline questionnaires were completed by 1,028 patients (88%). At 6 months, RT had a statistically significant impact on mean score for bowel symptoms (P = .02), diarrhea (P < .001), urinary function (P = .003), and erectile dysfunction (P = .008); by 3 years, however, there were no significant between-group differences in any domain. Generalized linear mixed modeling revealed no significant between-arm differences in any of the function scales but showed significant deterioration in both arms over time for Functional Assessment of Cancer Therapy–Prostate total score, treatment outcome index, and physical and functional well-being. Conclusion The addition of RT to ADT for patients with locally advanced prostate cancer significantly improved overall survival and had only modest and transient negative impact on relevant domains of HRQOL.
Health-Related Quality of Life in a Randomized Phase III Study of Bevacizumab, Temozolomide, and Radiotherapy in Newly Diagnosed Glioblastoma
Authors: Taphoorn Martin J.B. , Henriksson Roger , Bottomley Andrew , Cloughesy Timothy , Wick Wolfgang , Mason Warren P. , Saran Frank , Nishikawa Ryo , Hilton Magalie , Theodore-Oklota Christina , Ravelo Arliene , Chinot Olivier L. 
Published: May 2015

Purpose As glioblastoma progresses, patients experience a decline in health-related quality of life (HRQoL). Delaying this decline is an important treatment goal. In newly diagnosed glioblastoma, progression-free survival was prolonged when bevacizumab was added to radiotherapy plus temozolomide (RT/TMZ) versus placebo plus RT/TMZ (phase III AVAglio study; hazard ratio, 0.64; 95% CI, 0.55 to 0.74; P < .001). To ensure that addition of bevacizumab to standard-of-care therapy was not associated with HRQoL detriment, HRQoL assessment was a secondary objective. Patients and Methods Patients completed European Organisation for Research and Treatment of Cancer Quality of Life Questionnaires C30 and BN20 at each tumor assessment (Appendix Table A1 , online only). Raw scores were converted to a 100-point scale and mean changes from baseline scores were evaluated (stable: < 10-point change; clinically relevant deterioration/improvement: ≥ 10-point change). Deterioration-free survival was the time to deterioration/progression/death; time to deterioration was the time to deterioration/death. Results Most evaluable patients who had not progressed (> 74%) completed all HRQoL assessments for at least 1 year of treatment, and almost all completed at least one HRQoL assessment at baseline (98.3% and 97.6%, bevacizumab and placebo arms, respectively). Mean changes from baseline did not reach a clinically relevant difference between arms for most items. HRQoL declined at progression in both arms. The addition of bevacizumab to RT/TMZ resulted in statistically longer (P < .001) deterioration-free survival across all items. Time to deterioration was not statistically longer in the placebo plus RT/TMZ arm (v bevacizumab) for any HRQoL item. Conclusion The addition of bevacizumab to standard-of-care treatment for newly diagnosed glioblastoma had no impact on HRQoL during the progression-free period.
Feasibility of Large-Scale Genomic Testing to Facilitate Enrollment Onto Genomically Matched Clinical Trials
Authors: Meric-Bernstam Funda , Brusco Lauren , Shaw Kenna , Horombe Chacha , Kopetz Scott , Davies Michael A. , Routbort Mark , Piha-Paul Sarina A. , Janku Filip , Ueno Naoto , Hong David , De Groot John , Ravi Vinod , Li Yisheng , Luthra Raja , Patel Keyur , Broaddus Russell , Mendelsohn John , Mills Gordon B. 
Published: May 2015

Purpose We report the experience with 2,000 consecutive patients with advanced cancer who underwent testing on a genomic testing protocol, including the frequency of actionable alterations across tumor types, subsequent enrollment onto clinical trials, and the challenges for trial enrollment. Patients and Methods Standardized hotspot mutation analysis was performed in 2,000 patients, using either an 11-gene (251 patients) or a 46- or 50-gene (1,749 patients) multiplex platform. Thirty-five genes were considered potentially actionable based on their potential to be targeted with approved or investigational therapies. Results Seven hundred eighty-nine patients (39%) had at least one mutation in potentially actionable genes. Eighty-three patients (11%) with potentially actionable mutations went on genotype-matched trials targeting these alterations. Of 230 patients with PIK3CA/AKT1/PTEN/BRAF mutations that returned for therapy, 116 (50%) received a genotype-matched drug. Forty patients (17%) were treated on a genotype-selected trial requiring a mutation for eligibility, 16 (7%) were treated on a genotype-relevant trial targeting a genomic alteration without biomarker selection, and 40 (17%) received a genotype-relevant drug off trial. Challenges to trial accrual included patient preference of noninvestigational treatment or local treatment, poor performance status or other reasons for trial ineligibility, lack of trials/slots, and insurance denial. Conclusion Broad implementation of multiplex hotspot testing is feasible; however, only a small portion of patients with actionable alterations were actually enrolled onto genotype-matched trials. Increased awareness of therapeutic implications and access to novel therapeutics are needed to optimally leverage results from broad-based genomic testing.
Effect of Synthesis Route on Structural, Morphological Properties of Ce0.8Y0.2−xLaxO2 (x = 0, 0.1, 0.2)
Authors: Aouissi Mohamed Lamine , Ghrib Abdelaziz 
Published: May 2015

Abstract
In the present study, the solid solutions with a chemical composition of Ce0.8Y0.2−xLaxO2 (x = 0, 0.1, 0.2) were synthesized via two routes, by hydrothermal method using NaOH as precipitating agent at 230 °C for 15 h and by the sol–gel process using citric acid as chelating agent. Compounds have been characterized by X-ray powder diffraction (XRD), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and differential thermal analysis (DTA) techniques for appropriate characterization of the distinct thermal events occurring during synthesis. All the compounds crystallize in cubic fluorite structure. The ceria lattice expands depending on the ionic radii of the dopant cations, as indicated by X-ray diffraction study. The sol–gel oxide Ce0.8Y0.1La0.1O2 exhibits a good thermal stability compared with hydrothermal oxide. The microstructure of oxides synthesized by sol–gel showed porosity which increased with the lanthanum La3+ contents and on the other side the hydrothermal method gives single crystal oxides.
An open ecosystem engagement strategy through the lens of global food safety
Authors: Stacey Paul , Fons Garin , Bernardo Theresa M 
Published: May 2015

The Global Food Safety Partnership (GFSP) is a public/private partnership established through the World Bank to improve food safety systems through a globally coordinated and locally-driven approach. This concept paper aims to establish a framework to help GFSP fully leverage the potential of open models.In preparing this paper the authors spoke to many different GFSP stakeholders who asked questions about open models such as:what is it?what’s in it for me?why use an open rather than a proprietary model?how will open models generate equivalent or greater sustainable revenue streams compared to the current “traditional” approaches? This last question came up many times with assertions that traditional service providers need to see opportunity for equivalent or greater revenue dollars before they will buy-in. This paper identifies open value propositions for GFSP stakeholders and proposes a framework for creating and structuring that value.Open Educational Resources (OER) were the primary open practice GFSP partners spoke to us about, as they provide a logical entry point for collaboration. Going forward, funders should consider requiring that educational resources and concomitant data resulting from their sponsorship should be open, as a public good. There are, however, many other forms of open practice that bring value to the GFSP. Nine different open strategies and tactics (Appendix A) are described, including: open content (including OER and open courseware), open data, open access (research), open government, open source software, open standards, open policy, open licensing and open hardware. It is recommended that all stakeholders proactively pursue "openness" as an operating principle.This paper presents an overall GFSP Open Ecosystem Engagement Strategy within which specific local case examples can be situated. Two different case examples, China and Colombia, are presented to show both project-based and crowd-sourced, direct-to-public paths through this ecosystem.
Incidence of Stress Fractures in Indian Military Recruits
Authors: Deepak S , Dayanand M , Manoj Kumar HV , Batnagar Abhinav 
Published: May 2015

Introduction: Stress fractures are common in Military recruits during their training period and give rise to morbidity and loss of training hours. Some cadets with stress fractures are re-instated while some are expelled out of service resulting in attrition and economic loss.
Aim: A study to find out the incidence of stress fracture in Border Security force (BSF) military recruits in India.
Method: A prospective analysis of stress fractures among 2000 BSF cadets was done in a period of 9 months of their training. Recruits with metabolic abnormality were excluded. Clinical and radiological diagnosis was made and was followed up every 4 weeks till the time of union.
Result: The incidence of stress fractures among BSF trainees was found to be 15%. The incidence of stress fractures was highest during their initial weeks of physical training exercises and reached maximum at 12 weeks of the training schedule. 263 tibia, 24 fibula, 6 metatarsal, 5 femur shaft and 2 femoral neck stress fracture were seen. 3 tibia, 3 femur and 1 neck of femur fractures were operated and the rest were treated conservatively. All the fractures healed uneventfully.
Conclusion: Stress fractures are due to sudden increase in the amount and intensity of physical activity along with repeated forces due to running on a hard surface, improper training protocol, equipment. Higher incidence of stress fracture (15%) in our study suggests an appraisal and modification in training programme of military recruits.
Compact operators and algebraicK-theory for groups which act properly and isometrically on Hilbert space
Authors: Cortiñas Guillermo , Tartaglia Gisela 
Published: May 2015

AbstractWe prove theK-theoretic Farrell–Jones conjecture for groups with the Haagerup approximation property and coefficient rings andC*C^{*}-algebras which are stable with respect to compact operators. We use this and Higson–Kasparov’s result that the Baum–Connes conjecture holds for such a groupG, to show that the algebraic and theC*C^{*}-crossed product ofGwith a stable separableG-C*C^{*}-algebra have the sameK-theory.
Mediation and moderation in ratings of hostile jokes by men and women
Authors: Abel Millicent H. , Flick Jason 
Published: May 2015

AbstractTwo studies were conducted to examine sex differences in enjoyment of hostile jokes targeting men and women with a focus on examining mediation effects of masculinity and femininity and moderation effects of the jokes' offensiveness. These studies continued to support men and women enjoying jokes targeting the opposite sex more so than jokes targeting the same sex. However, in Study 1, masculinity and femininity mediated these differences for men with higher masculinity related to greater enjoyment of the female hostile jokes and higher femininity related to greater enjoyment of the male hostile jokes. Masculinity alone mediated the differences for women with higher masculinity related to greater enjoyment of the female-targeted jokes and yet, no relationship existed with femininity. In Study 2, both men and women rated the female-targeted jokes as more offensive than the male-targeted jokes. A moderation effect for the jokes' offensiveness occurred for women who rated highly offensive male-targeted jokes funnier than highly offensive female-targeted jokes. No effect for offensiveness occurred for men; men rated both offensive female-targeted and male-targeted jokes equally funny even though they rated the female jokes as more offensive.
The influence of empathizing and systemizing on humor processing: Theory of Mind and humor
Authors: Samson Andrea C. 
Published: May 2015

AbstractThis paper investigates the influence of empathizing and systemizing on cognitive and affective humor processing in two studies. Three cartoon types differing in their logical mechanisms (LMs) and cognitive requirements were presented to participants with high scores on one scale and low scores on the other (empathizers and systemizers): visual puns, semantic cartoons and Theory of Mind cartoons. Empathizers and systemizers were expected to process these cartoon types differently. While empathizers and systemizers did not differ in recognition time and comprehensibility in study one (