bluuebunny/crossref_metadata_2025_split huggingface dataset:
Passive sampling methods for contaminated sediments: Risk assessment and management
Authors: Greenberg Marc S , Chapman Peter M , Allan Ian J , Anderson Kim A , Apitz Sabine E , Beegan Chris , Bridges Todd S , Brown Steve S , Cargill John G , McCulloch Megan C , Menzie Charles A , Shine James P , Parkerton Thomas F 
Published: December 2013

Abstract
This paper details how activity-based passive sampling methods (PSMs), which provide information on bioavailability in terms of freely dissolved contaminant concentrations (Cfree), can be used to better inform risk management decision making at multiple points in the process of assessing and managing contaminated sediment sites. PSMs can increase certainty in site investigation and management, because Cfree is a better predictor of bioavailability than total bulk sediment concentration (Ctotal) for 4 key endpoints included in conceptual site models (benthic organism toxicity, bioaccumulation, sediment flux, and water column exposures). The use of passive sampling devices (PSDs) presents challenges with respect to representative sampling for estimating average concentrations and other metrics relevant for exposure and risk assessment. These challenges can be addressed by designing studies that account for sources of variation associated with PSMs and considering appropriate spatial scales to meet study objectives. Possible applications of PSMs include: quantifying spatial and temporal trends in bioavailable contaminants, identifying and evaluating contaminant source contributions, calibrating site-specific models, and, improving weight-of-evidence based decision frameworks. PSM data can be used to assist in delineating sediment management zones based on likelihood of exposure effects, monitor remedy effectiveness, and, evaluate risk reduction after sediment treatment, disposal, or beneficial reuse after management actions. Examples are provided illustrating why PSMs and freely dissolved contaminant concentrations (Cfree) should be incorporated into contaminated sediment investigations and study designs to better focus on and understand contaminant bioavailability, more accurately estimate exposure to sediment-associated contaminants, and better inform risk management decisions. Research and communication needs for encouraging broader use are discussed. Integr Environ Assess Manag 2014;10:224–236. © 2014 The Authors. Integrated Environmental Assessment and Management published by Wiley Periodicals, Inc. on behalf of SETAC.
Key Points
The freely dissolved concentration (Cfree) of a hydrophobic organic contaminant in sediment is a better predictor of bioavailability than the total concentration in bulk sediment. Passive sampling methods (PSMs) that target Cfree reduce uncertainty in site investigations by characterizing spatial and temporal contaminant trends, source contributions, calibrating models, and improving weight-of-evidence based decision frameworks. PSMs can help delineate sediment management zones, assess remedy effectiveness, and evaluate risk reduction following management action. Cfree can be used to better inform risk management decision making.
Incidence of low back pain related occupational diseases in the Netherlands
Authors: Miedema H.S. , van der Molen H.F. , Kuijer P.P.F.M. , Koes B.W. , Burdorf A. 
Published: December 2013

AbstractBackgroundUntil recently, no evidence‐based criteria were available to determine the work‐relatedness of low back pain (LBP) in an individual worker. Incidence figures for LBP that can be qualified as occupational disease (OD) are scarce. We studied the trend in the number of OD notifications due to LBP in the Netherlands and estimated incidence rates of LBP‐related OD notifications.MethodsWe developed an instrument for the assessment of work‐relatedness of non‐specific LBP (NLBP) in 2004, accompanied by an OD registration guideline. We analysed the trend in LBP‐related OD notifications in the register of the Netherlands Centre for Occupational Diseases (NCOD) from 2004 to 2011. We estimated incidence rates for LBP‐related OD notifications with data from a prospective cohort study, performed by NCOD in 2009–2011.ResultsAfter implementation of the instrument and guideline, we noticed a huge increase in numbers of LBP‐related OD‐notifications, from 0.7% of all notified ODs in 2004, via 8.6% in 2005 and 13.6% in 2008, to 9.1% in 2011. We estimated the incidence rate of ODs due to LBP at 24.1 per 100,000 worker years (19.2 for NLBP), with a large difference between men and women (31.3 and 3.2, respectively).ConclusionsThe instrument for the assessment of work‐relatedness of NLBP played an important role in the recognition of LBP‐related ODs. It provides a basis for a more uniform and objective evaluation of the role of work‐related risk factors in the occurrence of NLBP. This knowledge can be used to initiate or direct preventive actions towards subgroups with higher incidence rates.
Age does not modify the effects of treatment on pain in patients with low back pain: Secondary analyses of randomized clinical trials
Authors: Ferreira M.L. , Ferreira P.H. , Henschke N. , Kamper S.J. , Koes B. , Hayden J.A. , Maher C.G. 
Published: December 2013

AbstractBackgroundWhile many treatment options have been advocated to speed recovery in adults with back pain, it is still unclear whether older patients with back pain respond differently to treatment when compared to younger patients.AimsThis study aims to evaluate if age modifies response to treatment in patients with back pain, by conducting secondary analyses of seven randomized clinical trials of common interventions for back pain.MethodsData from 1233 participants were sourced from two randomized clinical trials on patients with acute back pain and five on patients with persistent back pain. Trials were conducted between 2001 and 2010 and assessed conservative treatments for back pain, including exercise, spinal manipulative therapy and anti‐inflammatory drugs. Individual participant data analyses were performed using a ‘one‐stage’ approach including all available data in a single two‐level model, with participants being one level and trials being the second level. Only pain outcomes assessed immediately after treatment were included in the analyses.ResultsMean combined age of included participants was 49 years (SD: 15.4). Multivariate fractional polynomial analyses revealed no significant interaction (p > 0.05) between age and treatment effect sizes in patients with low back pain for any of the treatment comparisons.ConclusionThese results offer preliminary evidence suggesting that the generally small effects of conservative treatments for low back pain are in fact observed across all age groups.
FURTHER EVIDENCE ON THE SPATIO‐TEMPORAL MODEL OF HOUSE PRICES IN THE UNITED STATES
Authors: Baltagi Badi H. , Li Jing 
Published: December 2013

SUMMARYHolly, Pesaran, and Yamagata (Journal of Econometrics 2010; 158: 160–173) use a panel of 49 states over the period 1975–2003 to show that state‐level real housing prices are driven by economic fundamentals, such as real per capita disposable income, as well as by common shocks, such as changes in interest rates, oil prices and technological change. They apply the common correlated effects estimator of Pesaran (Econometrica 2006; 74(4): 967–101), which takes into account spatial interactions that reflect both geographical proximity and unobserved common factors. This paper replicates their results using a panel of 381 metropolitan statistical areas observed over the period 1975–2011. Our replication shows that their results are fairly robust to the more geographically refined cross‐section units, and to the updated period of study. Copyright © 2013 John Wiley & Sons, Ltd.
Direct computation of current density to solve 3D electric conduction problems using facet elements with FEM
Authors: Ferrouillat Pauline , Guérin Christophe , Meunier Gérard , Ramdane Brahim , Carpentier Anthony 
Published: December 2013

SUMMARYIn this paper, an original alternative method to compute the current density J in two steps with the FEM is proposed, called the J0 − T formulation. The goal of this formulation is to respect the conservation of the normal component of the current density. The first step computes an initial source current density J0, and the second step computes an electric vector potential T. Finally, the current density J is computed using J = J0 + curl T. The first step ensures the conservation of the normal component of J0 between the facets of the mesh. To reach this condition, J0 is computed with facet finite elements. However, J0 is not unique, which is why a second step is added. In addition to the conditions of the first step, the second step corrects the tangential component of J. To reach these conditions, T is computed with edge finite elements. The J0 − T formulation is then validated on a right angle conductor with section and direction changes and on a 21‐turn copper coil. A conservation of the current is obtained with this formulation that is better than the classical electric scalar potential formulation. Copyright © 2013 John Wiley & Sons, Ltd.
Finite‐element discretisation of the eddy‐current term in a 2D solver for radially symmetric models
Authors: Vanoost Dries , De Gersem Herbert , Peuteman Joan , Gielen Georges , Pissoort Davy 
Published: December 2013

SUMMARYThis paper discusses the discretisation of the eddy‐current term of the magnetoquasistatic subset of the Maxwell equations in a 2D setting with radial symmetry. It is shown that dedicated finite element shape functions are needed to make sure that particular distributions of the magnetic flux density and the electric field strength can be resolved exactly. Moreover, the shape functions should obey a partition‐of‐unity property and should achieve a prescribed convergence order. The 2D solver with radial symmetry is applied to calculate the performance of a multi‐coil induction cooking system. Copyright © 2013 John Wiley & Sons, Ltd.
Impact of hyperthermia on pharmacokinetics of intraperitoneal mitomycin C in rats investigated by microdialysis
Authors: Sørensen Olaf , Andersen Anders Mikal , Kristian Alexandr , Giercksky Karl‐Erik , Flatmark Kjersti 
Published: December 2013

Background and ObjectivesPatients with peritoneal surface malignancies are treated with cytoreductive surgery and hyperthermic intraperitoneal chemotherapy, commonly using mitomycin C (MMC). The purpose of this study was to investigate impact of hyperthermia on pharmacokinetics of intraperitoneal MMC.MethodsIn 14 athymic nude male rats, microdialysis (MD) probes were implanted in jugular vein (V), hind leg muscle (M) and extraperitoneal space (XP). Probes were calibrated by retrodialysis. Intraperitonal chemotherapy perfusion (IPEC) was administered over 90 min with MMC 5 mg/kg and saline 0.9% 500 ml/kg at 35 and 41°C, defining the normothermic (NG) and hyperthermic groups (HG), respectively. MD and peritoneal perfusion fluid (PPF) samples were collected at 10 min intervals to determine MMC concentration.ResultsTime–concentration curves were virtually parallel between temperature groups, with equal peak concentrations (µM) of 0.3 (V), 0.7 (XP) and 0.3 (M). The following area under time–concentration curve (AUC) ratios were calculated: AUC PPF/AUC V were 69 in NG and 79 in HG (P = 0.54); AUC XP/AUC V were 2.7 in NG and 2.6 in HG (P = 0.90).ConclusionsIPEC provides high intraperitoneal MMC concentration and increased bioavailability in extraperitoneal tissue, combined with low systemic absorption. Hyperthermia at 41°C did not modify MMC pharmacokinetics. J. Surg. Oncol. 2014 109:521–526. © 2013 Wiley Periodicals, Inc.
Serum prognostic biomarkers in head and neck cancer patients
Authors: Lin Ho‐Sheng , Siddiq Fauzia , Talwar Harvinder S. , Chen Wei , Voichita Calin , Draghici Sorin , Jeyapalan Gerald , Chatterjee Madhumita , Fribley Andrew , Yoo George H. , Sethi Seema , Kim Harold , Sukari Ammar , Folbe Adam J. , Tainsky Michael A. 
Published: December 2013

Objectives/HypothesisA reliable estimate of survival is important as it may impact treatment choice. The objective of this study is to identify serum autoantibody biomarkers that can be used to improve prognostication for patients affected with head and neck squamous cell carcinoma (HNSCC).Study DesignProspective cohort study.MethodsA panel of 130 serum biomarkers, previously selected for cancer detection using microarray‐based serological profiling and specialized bioinformatics, were evaluated for their potential as prognostic biomarkers in a cohort of 119 HNSCC patients followed for up to 12.7 years. A biomarker was considered positive if its reactivity to the particular patient's serum was greater than one standard deviation above the mean reactivity to sera from the other 118 patients, using a leave‐one‐out cross‐validation model. Survival curves were estimated according to the Kaplan‐Meier method, and statistically significant differences in survival were examined using the log rank test. Independent prognostic biomarkers were identified following analysis using multivariate Cox proportional hazards models.ResultsPoor overall survival was associated with African Americans (hazard ratio [HR] for death = 2.61; 95% confidence interval [CI]: 1.58‐4.33; P = .000), advanced stage (HR = 2.79; 95% CI: 1.40‐5.57; P = .004), and recurrent disease (HR = 6.66; 95% CI: 2.54‐17.44; P = .000). On multivariable Cox analysis adjusted for covariates (race and stage), six of the 130 markers evaluated were found to be independent prognosticators of overall survival.ConclusionsThe results shown here are promising and demonstrate the potential use of serum biomarkers for prognostication in HNSCC patients. Further clinical trials to include larger samples of patients across multiple centers may be warranted.Level of EvidenceNA Laryngoscope, 124:1819–1826, 2014
Polymer Melting Kinetics Appears to be Driven by Heterogeneous Nucleation
Authors: Vyazovkin Sergey , Yancey Benjamin , Walker Kahleah 
Published: December 2013

A recently proposed method is used to parameterize the nucleation‐driven kinetics of poly(ε‐caprolactone) melting. The method is based on fitting a theoretically derived temperature dependence of the effective activation energy to the experimental dependence obtained from the Kissinger plot. Although the theoretical dependence fits the experimental one accurately, the fit gives rise to a surface free energy that is significantly smaller than the one obtained from crystallization data. A similar result is reported in other publications that make use of a homogeneous nucleation model for poly­mer melting. It is argued that a heterogeneous nucleation model is a more appropriate representation of the melting process and that its use resolves the problem of estimating the unusually small surface free energies.
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Directing Self‐Assembly of Nanoscopic Cylindrical Diblock Brush Terpolymers into Films with Desired Spatial Orientations: Expansion of Chemical Composition Scope
Authors: Cho Sangho , Yang Fan , Sun Guorong , Eller Michael J. , Clark Corrie , Schweikert Emile A. , Thackeray James W. , Trefonas Peter , Wooley Karen L. 
Published: December 2013

Diblock brush terpolymers (DBTs) with different fluorinated methacrylate‐based block segments are synthesized through sequential ring‐opening metathesis polymerizations and are used to prepare polymer thin films with predictable film thicknesses. These DBTs exhibit preferable substrate vertical alignments within the films, induced by the relatively lower surface energy of the fluorinated structural components, together with the overall cylindrical morphology of the brush architecture.
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A network approach to diagnostic biomarkers in progressive supranuclear palsy
Authors: Santiago Jose A. , Potashkin Judith A. 
Published: December 2013

ABSTRACTDiagnosis of progressive supranuclear palsy (PSP) remains challenging because of the clinical overlap with Parkinson's disease (PD). To date, disease‐specific biomarkers have yet to be identified. In the absence of reliable biomarkers, we used an integrated network approach to identify genes and related biological pathways associated with PSP. We tested a highly ranked gene in cellular whole‐blood samples from 122 patients enrolled in the Prognostic Biomarker Study. Biological and functional analysis identified 13 modules related to activation of leukocytes and lymphocytes, protein dephosphorylation, and phosphatase activity. Integration of these results with those from microarrays identified ptpn1 as a potential biomarker for PSP. Assessment of biomarker performance revealed that ptpn1 could be used to distinguish PSP patients from PD patients with 86% diagnostic accuracy. Ptpn1 may be a diagnostic marker useful for distinguishing PSP and PD. Further evaluation in a larger well‐characterized prospective study is warranted. © 2013 International Parkinson and Movement Disorder Society
Correction of proton resonance frequency shift MR‐thermometry errors caused by heat‐induced magnetic susceptibility changes during high intensity focused ultrasound ablations in tissues containing fat
Authors: Baron Paul , Deckers Roel , de Greef Martijn , Merckel Laura G. , Bakker Chris J.G. , Bouwman Job G. , Bleys Ronald L.A.W. , van den Bosch Maurice A.A.J. , Bartels Lambertus W. 
Published: December 2013

PurposeIn this study, we aim to demonstrate the sensitivity of proton resonance frequency shift (PRFS) ‐based thermometry to heat‐induced magnetic susceptibility changes and to present and evaluate a model‐based correction procedure.Theory and MethodsTo demonstrate the expected temperature effect, field disturbances during high intensity focused ultrasound sonications were monitored in breast fat samples with a three‐dimensional (3D) gradient echo sequence. To evaluate the correction procedure, the interface of tissue‐mimicking ethylene glycol gel and fat was sonicated. During sonication, the temperature was monitored with a 2D dual flip angle multi‐echo gradient echo sequence, allowing for PRFS‐based relative and referenced temperature measurements in the gel and T1‐based temperature measurements in fat. The PRFS‐based measurement in the gel was corrected by minimizing the discrepancy between the observed 2D temperature profile and the profile predicted by a 3D thermal model.ResultsThe HIFU sonications of breast fat resulted in a magnetic field disturbance which completely disappeared after cooling. For the correction method, the 5th to 95th percentile interval of the PRFS‐thermometry error in the gel decreased from 3.8°C before correction to 2.0–2.3°C after correction.ConclusionThis study has shown the effects of magnetic susceptibility changes induced by heating of breast fatty tissue samples. The resultant errors can be reduced by the use of a model‐based correction procedure. Magn Reson Med 72:1580–1589, 2014. © 2013 Wiley Periodicals, Inc.
3D multislab, multishot acquisition for fast, whole‐brain MR elastography with high signal‐to‐noise efficiency
Authors: Johnson Curtis L. , Holtrop Joseph L. , McGarry Matthew D.J. , Weaver John B. , Paulsen Keith D. , Georgiadis John G. , Sutton Bradley P. 
Published: December 2013

PurposeTo develop an acquisition scheme for generating MR elastography (MRE) displacement data with whole‐brain coverage, high spatial resolution, and adequate signal‐to‐noise ratio (SNR) in a short scan time.Theory and MethodsA 3D multislab, multishot acquisition for whole‐brain MRE with 2.0 mm isotropic spatial resolution is proposed. The multislab approach allowed for the use of short repetition time to achieve very high SNR efficiency. High SNR efficiency allowed for a reduced acquisition time of only 6 min while the minimum SNR needed for inversion was maintained.ResultsThe mechanical property maps estimated from whole‐brain displacement data with nonlinear inversion (NLI) demonstrated excellent agreement with neuroanatomical features, including the cerebellum and brainstem. A comparison with an equivalent 2D acquisition illustrated the improvement in SNR efficiency of the 3D multislab acquisition. The flexibility afforded by the high SNR efficiency allowed for higher resolution with a 1.6 mm isotropic voxel size, which generated higher estimates of brainstem stiffness compared with the 2.0 mm isotropic acquisition.ConclusionThe acquisition presented allows for the capture of whole‐brain MRE displacement data in a short scan time, and may be used to generate local mechanical property estimates of neuroanatomical features throughout the brain. Magn Reson Med 71:477–485, 2014. © 2013 Wiley Periodicals, Inc.
Bridging scale simulation of lattice fracture using enriched space‐time Finite Element Method
Authors: Qian Dong , Chirputkar Shardool 
Published: December 2013

SUMMARYA multiscale method that couples the space‐time Finite Element Method with molecular dynamics is developed for the simulation of dynamic fracture problems. A coarse scale description based on finite element discretization is established in the entire domain. This representation overlaps with a detailed atomistic description employed in the region immediately surrounding the crack tip with the goal to capture the initiation and propagation of the fracture. On the basis of the crack evolution informed by the atomistic simulation, an enrichment function is introduced to represent the fracture path. The space‐time framework further enables flexible choice of time steps in different regions of interest. Coupling between the fine and coarse scale simulation is achieved with the introduction of a projection operator and bridging scale treatment. The main feature of the work is that the evolution of the crack is adaptively tracked and the enrichment in the coarse scale simulation evolves along with it. As a result, we have a moving atomistic region in the concurrent simulation scheme. The robustness of the method is illustrated through examples involving crack propagation in hexagonal lattices with different orientations and loading conditions. Copyright © 2013 John Wiley & Sons, Ltd.
Survival of an infant with homozygous surfactant protein C (SFTPC) mutation
Authors: Arıkan‐Ayyıldız Zeynep , Caglayan‐Sozmen Sule , Isık Sakine , Deterding Robin , Dishop Megan K. , Couderc Remy , Epaud Ralph , Louha Malek , Uzuner Nevin 
Published: December 2013

SummaryLung diseases caused by surfactant protein C (SFTPC) mutations are inherited as autosomal traits with variable penetrance and severity or as sporadic disease caused by a de novo mutation on one allele. Here, we report the case of a child surviving with a homozygous surfactant protein C mutation after aggressive clinical management unlike his six siblings who died in infancy. This presentation raises the suspicion of an autosomal recessive inheritence that is discussed in this report. Pediatr Pulmonol. 2014; 49:E112–E115. © 2013 Wiley Periodicals, Inc.