bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation of 3, 3’-Disubstituted Oxindoles Derivatives as a Potential Anti- Cancer Tyrosine Kinase Inhibitors-molecular Docking and ADME Studies
Authors: Kaur Sukhmeet , Kaur Jasneet , Kaur Kirandeep , Mahajan Raghav , Jyotisina  , Kaur Kulwinder 
Published: July 2024

Aim:
This study aims to explore the binding interactions between synthesized 3,3’-Disubstituted Oxindoles and the HCK enzyme, with the specific goal
of discovering potential anticancer agents.

Background:
Cancer presents an ongoing global health challenge, necessitating the exploration of innovative therapeutic approaches. Isatin derivatives and
pyridine compounds hold great promise for the development of anticancer drugs due to their wide-ranging biological activities. Moreover, HCK
plays a significant role in chemotherapy resistance and reduced drug efficacy in clinical settings, highlighting its importance in the intricate
network of cancer pathophysiology. There is an urgent need for targeted interventions to regulate HCK activity and enhance cancer treatment
outcomes.

Methods:
In our study, we ensured meticulous optimization of protein and ligand preparation to guarantee accurate docking simulations. We conducted
molecular docking analyses using the state-of-the-art Glide module and assessed ADME properties using the Schrödinger suite's QikProp tool.

Results:
Through molecular docking, compounds 3c and 3e have emerged as promising anticancer agents with low docking scores against Tyrosine Kinase.
Further ADME analysis has provided valuable insights into the compounds' in-silico behaviour, while computed dipole moments have enhanced
our understanding of their physicochemical characteristics

Conclusion:
In this study, we explored how the synthesized compounds bind within the HCK active site, indicating potential anticancer properties. Through in
silico docking, we identified compounds 3c and 3e as possible anticancer agents, with the lowest docking scores of -7.621 and -7.602 kcal/mol
against Tyrosine Kinase. These findings emphasize the importance of computational approaches in drug discovery and offer valuable insights for
future research and development efforts.
Improvement of Taxane Biosynthesis in Cell Suspension Culture of Taxus
baccata after Elicitation with Titania-graphene Oxide Nanocomposite and
Coronatine
Authors: Gougeh Rahimeh Hemmati , Fatahi Reza , Shokrpour Majid , Naghavi Mohammad Reza , Varshochi Alidad , Mirjalili Mohammad Hossein , Nasiri Jaber 
Published: July 2024

Background:
There is a research gap about applying titania–graphene oxide (GO-TiO2)
nanocomposite and coronatine as elicitors in the cell suspension culture of T. baccata.

Objective:
The effects of two elicitors of GO-TiO2 (30 µg/L) and coronatine (10 µM) were examined
to improve the production of five different taxanes in the cell suspension culture of T. baccata.

Methods:
The suspension culture was prepared from the callus of T. baccata leaf explant. Next, both
elicitors of coronatine (10 µM) and GO-TiO2 (30 µg/L) were applied, sampling occurred 2, 4, 16
days after elicitation, and all five taxanes were quantified using HPLC.

Results:
The amounts of 10-DAB III ranged from 0.84 mg/L (for control) to 9.17 mg/L (day 16 after
elicitation with GO-TiO2). The production of BAC III ranged from zero (for control) to 7.69 mg/L
(day 4 with GO-TiO2). The maximum production of 10-deacetyltaxol was observed in control on day
16 with the amount of 1.85 mg/L, followed by a lower level of 0.825 mg/L on day 2 with coronatine
treatment. Considering cephalomannine, only elicitation of GO-TiO2 over all three different sampling
times (i.e., days 2, 4, and 16) resulted in sensible quantities. The maximum magnitudes of taxol were
acquired when GO-TiO2 was applied on day 4 and day 16 (1.345 mg/L and 0.965 mg/L, respectively).

Conclusion:
The results indicated the potential positive effects of both elicitors, particularly GOTiO2 nanocomposite, to improve taxanes production.
Evaluation of the Antioxidant and Antimicrobial Properties of Hydrosol Extract and Essential oil Derived from the Aerial Parts of Salvia argentea
Authors: Chikhi Ilyas , Kerzabi Rachida , Ziane Safaa Nor el Houda , Benyoucef Fatima , DIB Mohammed El Amine , Muselli Alain 
Published: July 2024

Background:
The increasing use of synthetic antimicrobials and antioxidants is a
concern for human health.

Aims:
The main objective of this study was to examine the chemical composition of the essential
oil extracted from Salvia argentea and its hydrosol extract while evaluating their antioxidant
and antimicrobial effects in vitro.

Materials and Methods:
The essential oil was obtained by hydrodistillation, while the hydrosol
extract was obtained by the liquid-liquid extraction method. The volatile compounds of the essential oil and hydrosol extract were analysed by gas chromatography (GC/FID) and gas chromatography coupled with mass spectrometry (GC/MS). Antioxidant activities were evaluated
using two methods: free radical scavenging activity (DPPH) and iron reduction antioxidant
power (FRAP), with BHT used as a positive control. The antimicrobial activity of the essential
oil and hydrosol extract was evaluated using the agar disc diffusion method.

Results:
According to the GC/FID and GC/MS analysis, the essential oil of S. argentea consisted mainly of germacrene D-4-ol (26.3%), epi-α-muurolol (19.2%), and epi-α-cadinol
(10.2%). In contrast, the hydrosol extract consisted of oxygenated compounds, including (E)-
phytol (23.5%), 14-hydroxy-δ-cadine (17.5%), caryophyllene oxide (11.5%), piperitone
(13.5%), and piperitone oxide (11.5%). The essential oil and hydrosol extract showed positive
antioxidant activity with both tests. It should be noted that the hydrosol extract showed the best
performance, with an IC50 of 8.3 g/L with the DPPH and an IC50 of 12.3 g/L with the FRAP test
compared to the BHT. The essential oil revealed antimicrobial activity with strong inhibition
against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Bacillus subtilis compared to Gentamicin.

Conclusion:
The results showed that essential oil and hydrosol extract have promising antimicrobial and antioxidant properties. These findings provide encouraging prospects for their potential use in the pharmaceutical or cosmetic sectors.
The Impact of Incentives on Data Collection for Online Surveys: Social Media Recruitment Study
Authors: Sobolewski Jessica , Rothschild Allie , Freeman Andrew 
Published: July 2024

Background
The use of targeted advertisements on social media platforms (eg, Facebook and Instagram) has become increasingly popular for recruiting participants for online survey research. Many of these surveys offer monetary incentives for survey completion in the form of gift cards; however, little is known about whether the incentive amount impacts the cost, speed, and quality of data collection.

Objective
This experiment addresses this gap in the literature by examining how different incentives in paid advertising campaigns on Instagram for completing a 10-minute online survey influence the response rate, recruitment advertising cost, data quality, and length of data collection.

Methods
This experiment tested three incentive conditions using three Instagram campaigns that were each allocated a US $1400 budget to spend over a maximum of 4 days; ads targeted users aged 15-24 years in three nonadjacent designated market areas of similar size to avoid overlapping audiences. Four ad creatives were designed for each campaign; all ads featured the same images and text, but the incentive amount varied: no incentive, US $5 gift card, and US $15 gift card. All ads had a clickable link that directed users to an eligibility screener and a 10-minute online survey, if eligible. Each campaign ran for either the full allotted time (4 days) or until there were 150 total survey completes, prior to data quality checks for fraud.

Results
The US $15 incentive condition resulted in the quickest and cheapest data collection, requiring 17 hours and ad spending of US $338.64 to achieve 142 survey completes. The US $5 condition took more than twice as long (39 hours) and cost US $864.33 in ad spending to achieve 148 survey completes. The no-incentive condition ran for 60 hours, spending nearly the full budget (US $1398.23), and achieved only 24 survey completes. The US $15 and US $5 incentive conditions had similar levels of fraudulent respondents, whereas the no-incentive condition had no fraudulent respondents. The completion rate for the US $15 and US $5 incentive conditions were 93.4% (155/166) and 89.8% (149/166), respectively, while the completion rate for the no-incentive condition was 43.6% (24/55).

Conclusions
Overall, we found that a higher incentive resulted in quicker data collection, less money spent on ads, and higher response rates, despite some fraudulent cases that had to be dropped from the sample. However, when considering the total incentive amounts in addition to the ad spending, a US $5 incentive appeared to be the most cost-effective data collection option. Other costs associated with running a campaign for a longer period should also be considered. A longer experiment is warranted to determine whether fraud varies over time across conditions.
Editorial
Authors: Sushartami Wiwik 
Published: July 2024

Tourism has served as and remains a significant driver of national development in many countries. Adopting a critical perspective in the field of tourism studies towards this circumstance will be advantageous for both the tourism sector and academia. The Gadjah Mada Journal of Tourism Studies contributes to the broader field of tourism studies, which aims to enhance the prosperity of the worldwide community. The current edition of the Gadjah Mada Journal of Tourism Studies contains the five articles listed below:An article on 'Delleng Degak', a tourism site in Sibagindar Village, Pakpak Bharat, North Sumatra.A study that examined the correlation between the components of the tourism destination, including attractions, accessibility, amenities, activities, and ancillary services, and visitor attitudes toward the destination in Nepal Van Java. An article that strives to clarify the potential re-conceptualization scheme of cultural resource management by analysing the emergence of the cultural tourism crisis in the COVID-19 pandemic era.A study that seeks to ascertain whether tourism has the potential to either alleviate or exacerbate inequality in the Yogyakarta Special Region Province. An article that attempts to shed light on the methods by which the 13 Lava Tour jeep communities in Umbulharjo Village were able to navigate, adapt to, and ultimately recuperate from job insecurity in the post-pandemic era. The Gadjah Mada Journal of Tourism Studies aims to promote the growth of tourism studies in the framework of scientific production and benefit a wider range of practical areas of the tourism industry by allowing for more critical and in-depth discussion in each article.
Atraksi Jamu Sebagai Daya Tarik Wisata pada Candi Borobudur, Kasultanan Yogyakarta, Kadipaten Pakualaman, dan Jamu Gingggang
Authors: Marsono Marsono , Irdana Nuryuda 
Published: July 2024

Budaya minum jamu pada bangsa Indonesia, khususnya Jawa telah berlangsung sejak zaman kuna, yaitu sejak 3.000.000 – 1.000 tahun sebelum Masehi. Hidup nenek moyang Jawa waktu itu tergantung pada alam. Dalam menjaga kesehatannya, mereka memanfaatkan unsur alam yang terdapat dalam dunia flora dan fauna. Caranya unsur-unsur dari dunia flora tumbuh-tumbuhan dan fauna itu diambil, dimanfaatkan secara langsung untuk jamu. Dokumen tertua menjaga kesehatan dengan minum jamu terdapat dalam relief Candi Borobudur, Magelang,Jawa Tengah. Candi ini dibangun pada abad ke-8 oleh Dinasti Sailendra, Kerajaan Mataram Kuna. Setelah mengenal huruf, ramuan jamu didokumentasikan dalam bentuk manuskrip, buku, dikerjakan secara intensif pada abad ke-18-19. Dokumen jamu di antaranya terdapat di Kasultanan Yogyakarta dan Kadipaten Pakualaman. Bahkan usaha produksi jamu sekarang juga masih eksis, di antaranya oleh Jamu Ginggang, Pakualaman, Yogyakarta. Teori klasivikasi jamu diterapkan guna menganalis berbagai jenis ramuan jamu. Klasivikasi jamu, meliputi: jenis jamu, komposisi bahan, cara membuat, foto produk jamu, khasiat, sampai jamu siap minum diberdayakan sebagai atraksi daya tarik wisata. Analisis komponen daya tarik wisata atas atraksi jamu tersebut disertakan. Metode penelitian dilakukan melalui: wawancara dengan nara sumber, pengamatan observasi langsung di lapangan, dan studi pustaka.
On the Application of Code-switching Strategy in Business English Teaching Under the Construction of “New Liberal Arts”
Authors: Ren Qing 
Published: July 2024

In English teaching classrooms, code switching is becoming a common phenomenon and as a teaching strategy it has been widely used by teachers in China. Under the background of construction of “New Liberal Arts”, this paper sets out to investigate teachers’ code-switching strategy in ESP (English for Special Purposes) teaching, especially in business English teaching classrooms. It is found that conscious and necessary code-switching in ESP teaching classrooms can make teaching more efficient, and its functions and positive effects on bilingual teaching should not be underestimated. It is hoped that this study can provide some suggestion to ESP teaching and help enhance an effective teaching mode by using code-switching strategy and suggest that teachers should be aware of this teaching tactic and use it technically in their teaching process.
Promoción de la Educación Física en la etapa de preescolar para el desarrollo integral de la niñez
Authors: Anchía-Umaña Irina 
Published: July 2024

En el ensayo se aborda la importancia de la Educación Física en la educación preescolar, enfatizando su papel en el desarrollo integral de las personas infantes. Se recalca la obligatoriedad de la Educación Física de acuerdo con la Ley 7800 en Costa Rica, así como el requerimiento de contar con personal docente especializado para impartir esta asignatura. También se discuten los beneficios de esta en la infancia, incluyendo el desarrollo de destrezas motoras, cognitivas y sociales, y se hace un llamado a prestar más atención a esta área a nivel de preescolar para fomentar hábitos saludables desde temprana edad. Además, se menciona que la falta de actividad física en la niñez puede tener consecuencias negativas en la salud a largo plazo, por lo que se recomienda contar con infraestructura adecuada para impartirla en preescolar. Así mismo, se destaca la importancia de contar con profesorado capacitado para promover un desarrollo óptimo en la infancia, dado que la Educación Física en esta etapa es crucial para el desarrollo motor, cognitivo, social y emocional. Se concluye que la Educación Física en la edad preescolar es importante para el desarrollo integral de la niñez, promoviendo hábitos saludables y contribuyendo a su bienestar a lo largo de su vida.
Implementación de una plataforma de experiencias de aprendizaje con profesionales de la Orientación: Una propuesta desde el enfoque de aprendizaje activo
Authors: VILLALOBOS BENAVIDES VICTOR 
Published: July 2024

El presente artículo tiene como objetivo analizar la experiencia de aprendizaje implementada en una plataforma de experiencias de aprendizaje en los procesos de capacitación continua de personas incorporadas al Colegio de Profesionales de Orientación, desde el enfoque de aprendizaje activo. Se utilizó una metodología sociocrítica y un diseño de investigación-acción participativa en un grupo de 13 personas colegiadas. Además, se llevó a cabo un diseño tecnopedagógico a través de sus etapas de diagnóstico, diseño, implementación y evaluación de la experiencia; el cual se desarrolla por medio de un curso incorporado a la oferta del Programa de Desarrollo Profesional, que fortalece el tema en atención socioemocional en entornos educativos. Los resultados muestran que, por medio de la plataforma Perusall®, se alcanza a integrar características del enfoque de aprendizaje activo. Entre las conclusiones, destacan la necesidad de elaborar propuestas centradas en los ambientes personalizados de aprendizaje; se encuentra que la plataforma de experiencias de aprendizaje (LXP) es una herramienta innovadora en el ámbito pedagógico e integradora de tecnologías recientes, así como que el diseño de conocimiento técnico pedagógico del contenido (TPACK) favorece una planificación estratégica y ágil en la elaboración de propuestas didácticas. Así mismo, se identifican características deseables para futuros procesos de capacitación a partir del enfoque propuesto, como mayores espacios sociocolaborativos, vinculación teórico-práctica con ambientes laborales y profundización del pensamiento crítico.
Institutions and Sustainability Entrepreneurship in SMEs: A Conceptual Model
Authors: Nordin Noorain Mohd , Koe Wei-Loon 
Published: July 2024

The government has integrated sustainability management into its agenda to rectify environmental degradation. A new study called “sustainability entrepreneurship”, which relates sustainability management with entrepreneurial endeavors has also been established. Sustainability management is crucial because it allows small and medium enterprises (SMEs) to develop competitive advantages by fulfilling customers’ demand for sustainable products. However, the participation of SMEs in sustainability management is low and many of them fail to disclose their environmental information. This phenomenon has caused problems in encouraging sustainability management commitment among SMEs and failure in achieving 17 Sustainable Development Goals (SDGs). Therefore, this paper aims to unravel the relationships of institutional elements on proclivity on sustainability entrepreneurship among SMEs. Based on a review of existing literature on Institutional factors, a proposed model was developed to assess proclivity towards sustainability entrepreneurship among SMEs. The result of this study would be useful to create the knowledge of institutional theory and the actual behavior of proclivity of sustainability entrepreneurship, to create new knowledge in the future. This research contributes to universities, policymakers and business practitioners. As for universities, it helps to develop a new model to enrich the literature in entrepreneurship studies. In terms of policymakers and business practitioners, it helps to identify important factors in developing true sustainability entrepreneurs among SMEs.
Screening of Cowpea (Vigna unguiculata (L). Walp) Genotypes for Resistance to Yellow Mosaic Disease Caused by CYMV and BCMV using Specific SSR Markers
Authors: Nagesha N. , Pramod S. A. , Krishna T. V. , Kanavi M. S. P. , Lakshminarayana Reddy C. N. 
Published: July 2024

The research was conducted during August to November, 2020 at the Department of Plant Biotechnology and Dryland Farming Unit, University of Agricultural Sciences (UAS), Gandhi Krishi Vigyana Kendra (GKVK), Bengaluru, Karnataka, India to validate the identified SSR markers associated with resistance to yellow mosaic diseases of cowpea using different genotypes. 120 germplasm lines cowpea were used for the study including two check varieties (IC-202781 and V-585). Disease scoring scale by Diwakar and Mali (1976) was used for the disease scoring. Among 120 genotypes, 52 genotypes with moderately resistance, 28 genotypes with no disease symptoms, 15 genotypes with resistance, 14 genotypes with moderately susceptible, 11 genotypes with susceptible and no highly susceptible genotypes were observed. These germplasms were screened using four simple sequences repeat markers (SSR) specific to Bean common mosaic virus and four SSR markers specific to cowpea yellow mosaic virus were selected from the existing databases. Out of the four SSR marker linked to BCMV tested for validation, only three markers (M15, M80, and Y 96) gave the desired amplification. Single marker analysis (SMA) revealed that out of four SSR markers, MA15 marker explains 3.96% of phenotypic variation, among 4 SSR markers linked to CYMV, only two markers (VM1 and AG1/AF48383) gave the desired amplification. SMA revealed that out of two SSR markers, AG1/AF48383 marker explains 3.80% of phenotypic variation. The resistant genotypes identified in this investigation can be used in future breeding programmes for introgression of disease resistant traits in important competitive varieties in the market.
Pemanfaatan Rusun Umum Oleh Non-MBR Kota Surabaya Ditinjau Menurut UU 20/2011 Tentang Rumah Susun
Authors: Tanta Jerisa Frabel 
Published: July 2024

In Indonesia, the government has initiated national development as a way to preserve the well-being of every Indonesian citizen in a just and equitable manner consistent with Pancasila values. In this regard, one of the key components that complies with the mandate in Article 28 H paragraph (1) of the 1945 Constitution of the Republic of Indonesia is the community's ability to meet housing needs. The government has created an alternate scheme by building public flats, particularly in terms of supplying housing for low-income comunities. Despite the fact that its construction was built for low-income communities, many of these flats are still not being utilized as planned. One illustration is that public flats in Surabaya is still occupied by a lot of individuals who are not exactly part of the low-income comunities grouping. As a result, there is an indication that there is a misalignment between the target audience of flats and the relevant regulations. Hence, This study discussed about whether the use of flats for Low-Income Communities in Surabaya has complied with UU Number 20 of 2011 regarding Public Flats, and what the legal implications are for residents who are not low-income comunities but live in public flats .
Sala Snoezelen: una herramienta neuropsicológica para el desarrollo de sociabilidad, comunicación, atención y motricidad en una población infantil con necesidades educativas especiales.
Authors: Martínez Leija Dulce Nohemí 
Published: July 2024

Los estudios documentados acerca de la intervención en Sala Snoezelen son escasos. En la presente investigación se realiza un análisis pre-test y post-test de una intervención grupal realizada en una sala de estimulación multisensorial Snoezelen. Para dicho análisis se aplicó el inventario de Desarrollo Batelle antes y después de 7 sesiones de tratamiento, haciendo hincapié en los aspectos de sociabilidad, atención, motricidad y comunicación. La población fue de 82 pacientes activos en el Centro Estatal de Rehabilitación y Educación Especial. Existieron diferencias significativas en la evaluación post-test de las variables de sociabilidad, mejorando la puntuación obtenida en el pre-test (M=1.55) con mayor puntuación en el post-test (M=1.66); en cuanto el pretest de atención (M=2.53) presentan una mejoría en el post-test de atención (M=2.67); los sujetos del pretest de motricidad (M=2.07) presentan una mejor motricidad en el post-test (M=2.13) y, por último, los sujetos del pretest de comunicación (M=1.58) presentan una mejoría en el post-test de comunicación (M=1.67). Se concluye, el impacto del trabajo en la sala snoezelen en el desarrollo de habilidades en participantes con alguna necesidad educativa especial.