bluuebunny/crossref_metadata_2025_split huggingface dataset:
A comprehensive overview of fabrication of biogenic multifunctional metal/metal oxide nanoparticles and applications
Authors: Ullah Rafi , Siraj Muhammad , Zarshan Farishta , Abbasi Banzeer Ahsan , Yaseen Tabassum , Waris Abdul , Iqbal Javed 
Published: August 2024

Abstract
The re-evaluation of animals, plants, and microorganisms for green synthesis has revolutionized the fabrication of metallic nanoparticles (MNPs). Green synthesis provides more biocompatibility compared to chemically synthesized MNPs, which make them ideal for diverse biological applications, especially in biomedicine. Various organisms have been extensively studied for green synthesis. Interestingly, angiosperms, algae, and animal-derived biomaterials like chitin and silk have shown a prominent role in synthesizing these nanoparticles. Moreover, bacteria, viruses, and fungi serve as sources of reducing agents, further expanding green synthesis possibilities. Despite progress, research on natural reducing agents remains relatively limited, with only a few exceptions such as tea and neem plants receiving attention. Green-synthesized nanoparticles have diverse applications in various fields. In biomedicine, they enable drug delivery, targeted therapies, and bio-imaging due to their enhanced biocompatibility. Some MNPs also exhibit potent antimicrobial properties, aiding in disease control and eco-friendly disinfection. Furthermore, green nanoparticles contribute to environmental remediation by purifying water and serve as sensitive biosensors for diagnostics and environmental monitoring. This review will provide the recent progress and advancements in the field of green synthesis (GS) of nanoparticles. It will also analyze the key characteristics and evaluate the advantages and disadvantages of GS compared to chemical synthesis.
Advances in synthesis and anticancer applications of organo-tellurium compounds
Authors: Al-joborae Fadhil Farhood M. , Al-Rawi Sawsan S. , Ibrahim Ahmad H. , Salman Abbas Washeel , Iqbal Muhammad Adnan 
Published: August 2024

Abstract
The present review deeply delves the major methods for the synthesis of organotellurium compounds along with their biological significance. Elaboration of various precursors (ligands) including Schiff bases, naphthoquinones, amino acids, β-hydroxy alkylated compounds, β-phenyltelluro alcohols, β-aryltelluro amines, β-aryl-chalcogenium azides, chalcogenobiotin, benzenesulfonamide, carbonic anhydrase, and Sulpha compounds has been briefly described. Furthermore, the article investigates their possible biological uses, specifically as antioxidant and anticancer agents while comparing their effectiveness with their respective ligands and with the standard medications in terms IC50 values. All types of details are haunted to make the information a priceless resource for researchers who wish to probe deeper into and examine the diverse roles that organotellurium complexes play in biological settings.
Endocrinological features and epileptic encephalopathy in COX deficiency due to SCO1 mutations: case series and review of literature
Authors: Barbato Alessandro , Gori Giulia , Sacchini Michele , Pochiero Francesca , Bargiacchi Sara , Traficante Giovanna , Palazzo Viviana , Tiberi Lucia , Bianchini Claudia , Mei Davide , Parrini Elena , Pisano Tiziana , Procopio Elena , Guerrini Renzo , Peron Angela , Stagi Stefano 
Published: August 2024

Context
Cytochrome C oxidase (COX) is the fourth component of the respiratory chain and is located within the internal membrane of mitochondria. COX deficiency causes an inherited mitochondrial disease with significant genetic and phenotypic heterogeneity. Four clinical subtypes have been identified, each with distinct phenotypes and genetic variants. Mitochondrial complex IV deficiency nuclear type 4 (MC4DN4) is a form of COX deficiency associated with pathogenic variants in the SCO1 gene.

Case description
We describe three patients with MC4DN4 with developmental and epileptic encephalopathy (DEE), hypopituitarism, and SCO1 pathogenic variants. These patients’ phenotypes considerably differ from previously reported MC4DN4 phenotypes as they associate DEE with progressive hypopituitarism and survival beyond the first months after birth. Pituitary deficiency in these patients progressively worsened and mainly involved growth hormone secretion and thyroid function.

Conclusions
Our findings expand knowledge of phenotypic variability in MC4DN4 and suggest that SCO1 is a candidate gene for genetic hypopituitarism and DEE.

Significance statement
Our paper describes three patients affected by MC4DN4 with hypopituitarism and developmental and epileptic encephalopathy (DEE), two features that have never been associated with this condition. In addition, we reviewed the clinical features of all previous cases of MC4DN4 to give the other clinicians a wide picture of the clinical phenotype of this genetic disease. We hope that the publication of our data may help others to identify this disease and consider the chance to analyze the SCO1 gene in cases of DEE associated with pituitary dysfunction. Our article contributes to expanding the spectrum of genetic hypopituitarism and proposes a model to explain an association between this condition, mitochondrial anomalies, and neurodevelopmental defects.
Trade signs in antiquity
Authors: Vida Sándor , Kováts Borbála 
Published: August 2024

AbstractThe paper discusses the inscriptions of two ancient artifacts, the fragment of an Egyptian wine jug (Museum of Fine Arts, Budapest), and a terra sigillata bowl made by Pacatus (Aquincum Museum, Budapest), and seeks to situate them in the history of trade signs. In ancient Egypt, signs predominantly indicated details such as the place and date of production, and the quality of the product, while in Rome trade signs conveyed information concerning the origin of the product through the craftsman or workshop.
Pengaruh Konseling Individu Terhadap Koping Siswa Dimasa Pandemi Covid-19
Authors: Hazimah Nisrina Rif'ati 
Published: August 2024

ABSTRAKTujuan daripada penelitian saat ini ialah untuk mencari tahu perihal layanan konseling individu pada anak didik MTs Persis 03 Pameungpeuk pada saat endemi covid19 ; untuk mencari tahu koping anak didik MTs Persis 03 Pameungpeuk ; serta mencari tahu pengaruh layanan konseling individu terhadap anak didik MTs Persis 03 Pameungpeuk pada saat endemi covid19. Metode deskriptif jenis survei dipakai pada pengamatan ini dengan populasi serta sampel anak peserta didik MTs Persis 03 Pameungpeuk kelas VII. Pendekatan kuantitatif dipakai pada peneitian ini, data primer yang didapat melalui kuesioner, wawancara, serta data-data dari MTs Persis 03 Pameungpeuk dengan dokumentasi sebagai data pendukung yang mempunyai relevansi dalam pengamatan ini. beserta teknik random sampling yang dipakai yakni non probabilit. Penelitian ini memperlihatkan bahwa konseling individu yang diadakan di MTs Persis 03 Pameungpeuk memakai strategi yang Islami serta terjalinnya hubungan yang compatibility. Sesudah layanan konseling individu dilangsungkan, banyaknya anak didik yang mampu manangani persoalan mereka memakai pendekaran koping dengan fokus pada persoalan serta emosial yang bersumber dari hasil data. ABSTRACTThe purpose of the current study is to find out about individual counseling services for students at MTs Persis 03 Pameungpeuk during the COVID-19 endemic; to find out the coping of MTs Persis 03 Pameungpeuk students; and find out the effect of individual counseling services on students at MTs Persis 03 Pameungpeuk during the COVID-19 endemic. Descriptive survey method was used in this observation with the population and sample of students of MTs Persis 03 Pameungpeuk class VII. A quantitative approach is used in this research, primary data obtained through questionnaires, interviews, and data from MTs Persis 03 Pameungpeuk with documentation as supporting data that has relevance in this observation. along with the random sampling technique used, namely non-probability. This study shows that individual counseling held at MTs Persis 03 Pameungpeuk uses an Islamic strategy and establishes a compatibility relationship. After individual counseling services are carried out, many students are able to handle their problems using a coping approach with a focus on problems and emotions that come from data results.
METAFISIKA EMPIRIK DALAM PEMIKIRAN DAVID HUME
Authors: Saumantri Theguh 
Published: August 2024

Empirisme merupakan salah satu aliran filsafat yang memiliki peranan penting dalam ranah pengetahuan. Salah satu tokoh dalam aliran empirisme ini adalah David hume seorang filsuf modern yang lahir pada zaman renaissance. Sebagai rival rasionalisme, pengetahuan ini menempatkan pengalaman sebagai sumber utama dalam objektifikasi kebenaran baik lahiriah maupun batiniah. Fokus pembahasan dalam penelitian ini adalah mengkaji wilayah metafisika perspektif filsafat empiris-nya david hume. Penelitian ini merupakan penelitian kepustakaan (library research) dengan pendekatan filosofis yang bertujuan melakukan pencarian dan menelaah terhadap data atau informasi mengenai pemikiran tokoh. Hasil dari penelitian ini ditemukan bahwa bangunan metafisika empirik yang diletakkan oleh Hume ternyata masih lemah dalam mengembangkan ilmu pengetahuan. Filsafatnya lebih mengarah kepada pemikiran analitis, kritis, dan skeptis yang pada akhirnya empirisme Hume terjebak pada skeptisisme dan nihilisme.
Efektivitas Kemampuan Berpikir Kritis dalam Menangkal Hoaks
Authors: Siga Willfridus Demetrius , Seva Kristining , Her Riadi Tri Joko 
Published: August 2024

ABSTRAK Hoaks dibuat seseorang/kelompok dengan beragam tujuan. Hoaks biasanya muncul ketika sebuah isu mencuat ke permukaan, namun banyak hal yang belum terungkap atau menjadi tanda tanya. Menyikapi konten media sosial dan media berita daring yang menawarkan informasi yang bermuatan hoaks dibutuhkan kemampuan berpikir kritis. Penelitian ini bertujuan untuk mengidentifikasi efektivitas kemampuan berpikir kritis sebagai sebuah cara dalam menangkal hoaks yang disajikan dalam bentuk informasi pada media media sosial dan media berita daring. Metode penelitian yang digunakan dalam penelitian ini adalah metode kombinasi (mixed method) dengan desain konvergen. Metode kuantitatif mengumpulkan data menggunakan teknik survei. Sedangkan, untuk metode kualitatif dilakukan dengan teknik wawancara mendalam yang hasilnya kemudian dielaborasi dengan data kuantitatif dan disajikan secara deskriptif. Unit analisis penelitian ini adalah 131 mahasiswa rentang usia 16 – 27 tahun dengan beragam jurusan yang tersebar di Perguruan Tinggi Negeri (PTN) dan Perguruan Tinggi Swasta (PTS) di Kota Bandung. Hasil penelitian menunjukkan mahasiswa mengakses informasi terkait informasi gaya hidup dan politik lebih dari sekali dalam sehari dan sungguh menyadari bahwa setiap informasi/berita merupakan representasi sudut pandang atau ideologi tertentu. Menariknya, responden merasa perlu mengetahui bagaimana cara media menyajikan informasi/berita dengan segala kepentingan yang melatar belakanginya. Suburnya infomasi hoaks mendorong mahasiswa mengkases banyak informasi dengan tetap mengedepankan rasionalitas dan objektivitas data. Tingkat kepercayaan terhadap informasi atau berita yang disajikan oleh media digital belum menunjukkan persentasi yang memuaskan. Salah satu alasannya karena kepentingan mahasiswa mengakses informasi atau berita masih sekedar mencari informasi hiburan dan mengisi waktu luang. Mahasiswa juga menilai bahwa media informasi/berita digital sangat berpengaruh pada pembentukkan pola pikir. Hoaks menimbulkan kepanikan, kegaduhan, menggiring opini publik untuk mudah menerima dan memercayainya sebagai sebuah kebenaran. Maka berpikir kritis menjadi menjadi sebuah keharusan kompetensi untuk mendengarkan dan membaca logika masyarakat, literasi media sejak dini, bijaksana dalam menyampaikan pesan, telusuri sumber berita, dan analisis wacana kritis.
PENGARUH PENAMBAHAN PROBIOTIK PROBIO 7 DENGAN DOSIS YANG BERBEDA PADA PAKAN TERHADAP PERTUMBUHAN DAN KELANGSUNGAN HIDUP BENIH IKAN LELE (Clarias sp)
Authors: Rizkyani Nur , Mulis Rully Tuiyo 
Published: August 2024

Penelitian ini untuk mengetahui pengaruh penambahan probiotik probio 7 dengan dosis yang berbeda pada pakan terhadap pertumbuhan dan kelangsungan hidup benih ikan lele (Clarias sp). metode yang digunakan dalam penelitian ini adalah eksperimen. Hewan uji yang digunakan adalh benih ikan lele (Clarias sp)sebanyak 240 ekor, dengan perlakuan A (Kontrol), B (dosis probiotik 10 ml/1), C (doses probiotik 15 ml/1), D (Dosis Probiotik 20 ml/1). Wadah yang digunakan adalah akuarium dengan ukuran 60x40x40 sebanyak 12 buah dan masing-masing diisi sebanyak 40 L dengan ikan sebanyak sebanyak 20 ekor.penelitian ini dilaksanakan selama 30 hari. Rancangan yang digunakan pada penelitian ini adalah ranvangan acak lengkap (RAL) menggunakan Analisis of Varians (ANOVA). Hasil yang diperoleh menunjukkan bahwa perlakuan berpengaruh nyatan terhadap pertumbuhan panjang mutlak. Pertumbuhan p anjang mutlak tertinggi terdapat pada perlakuan C 3,74 cm, D 3,39 cm B 2,93 cm dan A 2,85 cm.
Culture Shock Pada Mahasiswa Perantau Asal Jakarta Yang Berkuliah Di UIN Sunan Ampel Surabaya (Pengaplikasian Teori Differensiasi Budaya)
Authors: Hanafianto Ahmad Dendy 
Published: August 2024

Sebagai mahasiswa rantau, tentu ada berbagai hal yang sebagai atensi khusus dalam proses belajar mengajar di perguruan tinggi. Bagi mahasiswa rantau, beradaptasi dengan lingkungan baru dapat menjadi tantangan tersendiri. .Untuk mengatasi culture shock, mahasiswa rantau dapat melakukan beberapa langkah seperti mengenal lingkungan baru dengan lebih baik, mencari teman dan kelompok studi atau komunitas Jenis penelitian ini merupakan kualitatif menggunakan pendekatan fenomenologis Ada penelitian lapangan (field research), yaitu jenis Jelajahi dengan mengumpulkan informasi di bidang ini. Penelitian kualitatif membuat data naratif berupa istilah-istilah tertulis atau ekspresi dan konduite yg diamati. Teori differensiasi budaya adalah sebuah teori sosiologi yang menjelaskan bagaimana budaya berubah dan bagaimana budaya yang berbeda terbentuk di dalam sebuah masyarakat.Setelah melakukan wawancara dengan beberapa anggota Organisasi Mahasiswa Daerah Jabodetabek UIN Sunan Ampel Surabaya, didapati beberapa fakta dan data sebagai berikut. Pertama adalah hampir semua mahasiswa yang termasuk anggota di Organisasi Mahasiswa Daerah Jabodetabek UIN Sunan Ampel Surabaya mengalami Culture Shock karena perbedaan budaya serta daerah dengan tempat asalnyaCulture Shock dan Teori Differensiasi Budaya sangatlah berkaitan erat dengan kehidupan mahasiswa perantauan asal Jakarta yang berkuliah di UIN Sunan Ampel Surabaya. Keterkaitan antara Culture Shock dengan teori differensiasi budaya adalah Culture Shock terjadi karena perbedaan-perbedaan yang ada di antara budaya asal dengan budaya yang baru ditemui.
Pola Interaksi Sosial Anak Berkebutuhan Khusus Pada Siswa Tunagrahita di Sekolah Luar Biasa Bina Bangsa Desa Ngelom Kecamatan Taman Kabupaten Sidoarjo
Authors: Lubis Achmad Hadyul Mubarok Lubis 
Published: August 2024

Penelitian ini mengkaji mengenai pola interaksi sosial anak berkebutuhan khusus (ABK) pada siswa tunagrahita di Sekolah Luar Biasa Bina Bangsa, Desa Ngelom, Kecamatan Taman, Kabupaten Sidoarjo yang dipengaruhi berbagai faktor. Penelitian ini akan membahas tentang bagaimana pola interaksi sosial pada ABK di SLB Bina Bangsa, Desa Ngelom, Kecamatan Taman, Kabupaten Sidoarjo dan apa faktor yang mempengaruhi pola interaksi sosial pada ABK selama proses pembelajaran di SLB Bina Bangsa. Metode penelitian yang digunakan yaitu kualitatif dengan pendekatan fenomenologi. Teknik pengumpulan data dalam penelitian ini berupa observasi, wawancara, dan juga dokumentasi. Pola interaksi sosial anak berkebutuhan khusus pada siswa tunagrahita dalam penelitian ini dianalisis menggunakan teori interaksionisme simbolik dari George Herbert Mead.Hasil penelitian menunjukkan bahwa pola interaksi sosial ABK pada siswa tunagrahita di SLB Bina Bangsa terdiri dari beberapa aspek, yaitu kerjasama, akomodasi, dan asimilasi. Dan pola interaksi sosial tersebut dipengaruhi oleh berbagai faktor seperti lingkungan sosial, dukungan sosial, kebutuhan dasar, kemampuan kognitif, dan tingkat kemandirian. Pola interaksi sosial ABK selama proses pembelajaran juga mempengaruhi kemampuan untuk beradaptasi dengan lingkungan sekitar dan memenuhi kebutuhan sosial mereka.
Cooperative Business Development Model in the Digital Era: A Theoretical Approach
Authors: Suparno Suparno , Saptono Ari , Effendi Mohammad Sofwan , Wibowo Agus , Lestari Fitra Dila , Mukhtar Saparuddin , Fei Wang , Geminastiti Kinanti , Khalik Rahmatul , Murniawaty Indri , Narmaditya Bagus Shandy 
Published: August 2024

This research aims to develop theoretical prepositions of cooperative business development in the digital era as part of the education and development of cooperatives. The problem studied is the low competitiveness of cooperatives, on the other hand, the high public interest in various cooperative products so modeling solutions is needed in managing cooperatives competitively in the digital era. The cooperative needs to be studied and developed based on superior work performance so that it has a professional management process. This research examines performance theory, with a digital innovation approach. The method used is qualitative with literature and literature studies, theoretically and historically analyzing the development of cooperatives globally and their competitiveness. The results show that employee digital skills, service quality, and member loyalty with active participation predict cooperative business development in the digital era. This study also explains the theoretical measurement factors for future researchers and describes, explains, and measures cooperative business development based on the theoretical study. For future researchers to be able to develop this research empirically with exploratory factor analysis or confirmatory factor analysis, with a wider population and sample. Keywords: Cooperative business, Business development, Digital era, Innovative performance, Service quality
Big Five Personality Traits and Employee Performance: Evidence from Mediation and Moderation Analysis
Authors: Desaili David , Anjaningrum Widiya Dewi , Viloria Vivien Amor 
Published: August 2024

In response to heightened university competition, Institut Teknologi dan Bisnis Asia Malang has witnessed a decline in students' enrollment. To navigate this challenge, the institution aims to establish a competitive edge by adopting the resource-based view theory. This strategic approach emphasizes the unique qualities of the institution's resources, with human capital emerging as the most pivotal. This study involves 120 respondents, exploring the influence of Big Five personality traits, organizational commitment, and attitude toward digital work on employee performance. Using the partial least square structural equation modelling (PLS-SEM) method, the findings indicate that the Big Five personality traits insignificantly impact employee performance. The Big Five personality traits significantly impact organizational commitment, and organizational commitment significantly impacts employee performance, in which the organizational commitment serves as a complete mediation. In addition, attitudes towards digital work as quasi-moderating can strengthen the influence of the Big Five personality traits on employee performance. Further research is recommended to analyze the relationship between the dimensions of each variable in more depth. Keywords: Big five personality traits, Organizational commitment, Attitude toward digital work, Employee performance
Identifying the frequency of mismatch repair deficiency in endometrial carcinoma in a tertiary care hospital
Authors: Khatoon Farhana , Begum Shirin Akter , Dey Bishnu Pada , Islam Jannatul , Akter Naznine , Nihar Fatema , Ara Rowson , Alam Babrul 
Published: August 2024

Background: Mismatch repair deficiency (MMRd) is a pivotal genetic defect that significantly contributes to the pathogenesis of various cancers, particularly colorectal and endometrial cancers. The mismatch repair (MMR) system is essential for maintaining genomic stability by correcting base-base mismatches and insertion-deletion loops that occur during DNA replication. The aim of the study was to investigate the frequency and patterns of MMR protein deficiency in endometrial cancer and their association with clinical and pathological characteristics.
Methods: This cross-sectional observational study was conducted at the Department of Gynecological Oncology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from March 2022 to February 2023. The study included all patients admitted with histologically confirmed endometrial carcinoma, diagnosed via endometrial fractional curettage or diagnostic D&C, who were admitted for surgical management.
Results: In this study of endometrial cancer, 49 participants were analyzed for mismatch repair (MMR) protein status. MMR deficiency (MMRd) was observed in 16 cases (32.7%). Among 16 MMR deficient EC, isolated single protein loss was in 5 (31.25%) and multiple loss was in 11(68.75%) cases. Family history of malignancy often correlated with MSH2 loss. MMRd was significantly associated with higher cancer stages. Immunohistochemistry proved effective for identifying MMR status, facilitating Lynch syndrome screening and subsequent clinical management. These findings underscore the importance of MMR testing in endometrial cancer for prognosis and treatment decisions.
Conclusions: This study underscores the importance of mismatch repair (MMR) protein status in the prognosis of endometrial cancer (EC).
A comparative evaluation of ultrasound guided dual transversus abdominis plane block versus erector spinae plane block for postoperative analgesia in patients undergoing laparoscopic cholecystectomy: A randomised prospective study
Authors: Angral Rajesh , Gupta Aleesha , Kalsotra Sanjay Kumar , Chander Anshuman Mahesh , Sharma Raj Rishi 
Published: August 2024

: Effective pain control after laparoscopic cholecystectomy (LC) is crucial for early patient mobilization, facilitating a speedy recovery and avoiding several complications. Ultrasound (USG) guided bilateral dual transversus abdominis plane block (DTAPB) and erector spinae plane block (ESPB) are effective for providing postoperative pain relief after LC.A prospective randomised, study comprising of 100 patients posted for elective LC. To compare the effectiveness of USG-guided DTAPB and ESPB for providing postoperative pain relief in patients undergoing LC. A total of 100 patients aged 18-70 years, were included in the study and divided into two groups of 50 patients each. Group DTAPB received bilateral DTAPB and group ESPB received bilateral ESPB, using 50 ml of 0.25% ropivacaine with 8 mgs of dexamethasone. Post operative visual analogue score (VAS) score, time to first analgesia request, total number of analgesic doses required in 24 hours (hrs) and complications if any were noted. VAS score was higher in DTAPB group than ESPB group at 1,2,6,8 and 14 hrs. In DTAPB group patients requested analgesia after an average of 8 ±2.0 hrs, whereas in ESPB group they requested after 12 ± 3.16 hrs. In ESPB group 45 patients needed single analgesic dose and only 5 needed second analgesic doses. However, in DTAPB group 35 patients received single and 15 patients received second analgesic dose. Side effects were comparable in both the groups.USG-guided bilateral ESPB with 50 ml of 0.25% ropivacaine plus dexamethasone is an effective approach in reducing postoperative pain following LC.