bluuebunny/crossref_metadata_2025_split huggingface dataset:
Rapid Surface Cooling by ThermoSuit System Dramatically Reduces Scar Size, Prevents Post‐Infarction Adverse Left Ventricular Remodeling, and Improves Cardiac Function in Rats
Authors: Dai Wangde , Herring Michael J. , Hale Sharon L. , Kloner Robert A. 
Published: June 2015

Background

The long‐term effects of transient hypothermia by the non‐invasive ThermoSuit apparatus on myocardial infarct (
MI
) scar size, left ventricular (
LV
) remodeling, and
LV
function were assessed in rat
MI
model.

Methods and Results

Rats were randomized to normothermic or hypothermic groups (n=14 in each group) and subjected to 30 minutes coronary artery occlusion and 6 weeks of reperfusion. For hypothermia therapy, rats were placed into the ThermoSuit apparatus at 2 minutes after the onset of coronary artery occlusion, were taken out of the apparatus when the core body temperature reached 32°C (in ≈8 minutes), and were then allowed to rewarm. After 6 weeks of recovery, rats treated with hypothermia demonstrated markedly reduced scar size (expressed as % of left ventricular area: hypothermia, 6.5±1.1%; normothermia, 19.4±1.7%;
P
=1.3×10
−6
); and thicker anterior
LV
wall (hypothermia, 1.57±0.09 mm; normothermia, 1.07±0.05 mm;
P
=3.4×10
−5
); decreased postmortem left ventricular volume (hypothermia, 0.45±0.04 mL; normothermia, 0.6±0.03 mL;
P
=0.028); and better
LV
fractional shortening by echocardiography (hypothermia, 37.2±2.8%; normothermia, 18.9±2.3%;
P
=0.0002) and
LV
ejection fraction by
LV
contrast ventriculography (hypothermia, 66.8±2.3%; normothermia, 56.0±2.0%;
P
=0.0014).

Conclusions

Rapid, transient non‐invasive surface cooling with the ThermoSuit apparatus in the acute phase of
MI
decreased scar size by 66.5%, attenuated adverse post‐infarct left ventricular dilation and remodeling, and improved cardiac function in the chronic phase of experimental
MI
.
Host Defense Proteins in Breast Milk and Neonatal Yeast Colonization
Authors: Chow Brian D.W. , Reardon Juliann L. , Perry Emily O. , Laforce-Nesbitt Sonia S. , Tucker Richard , Bliss Joseph M. 
Published: June 2015

Background: Colonization increases risk for invasive candidiasis in neonates. Breast milk host defense proteins may affect yeast colonization of infants. Objective: This study aimed to evaluate breast milk host defense proteins relative to yeast colonization in infants. Methods: Infants admitted for longer than 72 hours to the neonatal intensive care unit at Women & Infants Hospital in Providence, Rhode Island, were eligible. After consent, expressed breast milk and swabs from oral, rectal, and inguinal sites from infants were cultured weekly for 12 weeks, or until discharge, transfer, or death. Breast milk was tested for levels of human lactoferrin, lysozyme, apolipoprotein J, mucin-1, dermcidin, and soluble CD14 using commercial ELISA. Concentrations of these components were compared in breast milk received by infants who were colonized or not colonized with yeast. Results: From an original cohort of 130, 61 infants had samples available for this subanalysis. A convenience sample of stored breast milk was analyzed. Median lactoferrin, apolipoprotein J, and mucin-1 did not differ between colonized and uncolonized groups. Soluble CD14 was higher in the surface-colonized group (1.8 μg/mL, n = 12) compared with the surface-uncolonized group (1.6 μg/mL, n = 12, P = .02). Median lysozyme levels were higher in the surface-uncolonized group (483.0 ng/mL, n = 12) versus the surface-colonized group (298.3 ng/mL, n = 12, P = .04). Median dermcidin levels were higher in the surface-uncolonized group (19.4 ng/mL, n = 12) versus the surface-colonized group (8.7 ng/mL, n = 12, P = .04). Conclusion: This study shows an association between colonization with Candida in neonates and lower levels of lysozyme and dermcidin in received breast milk. Further study is needed to confirm these findings.
Symptoms of attention deficit hyperactivity disorder in patients with systemic lupus erythematosus
Authors: Gao Y , Lo Y , Mok M Y 
Published: June 2015

Objectives Cognitive function and mood disturbance are common in patients with systemic lupus erythematosus (SLE). This study aims to examine whether SLE patients have more features of adult attention deficit hyperactivity disorder (ADHD) and their relation to anxiety and depressive symptoms. Methods Symptoms and clinically significant items of the inattention and hyperactivity/impulsivity domains of ADHD were examined in Part A and Part B by the screening instrument of the ADHD Self-Reported Scale (ASRS), respectively. Anxiety and depressive symptoms were measured by HADS-A and HADS-D, respectively. Results There were no differences in symptom scores of inattention and hyperactivity/impulsivity between inactive SLE patients ( n = 117) and age- and sex-matched controls ( n = 64). However, SLE patients had more clinically significant items in the inattention domain compared with controls ( p = 0.006), particularly among those who had previous cerebral involvement ( p = 0.004). Patients who had psychiatric diseases had more clinically significant items in the hyperactivity/impulsivity domain ( p = 0.006). Possible ADHD was found in 7.7% of SLE and 6.3% of healthy individuals ( p = 1.00) by the screening tool. Patients with higher inattention symptom scores were more likely to be unemployed but not for duration of education and smoking habit. Anxiety and depressive symptoms correlated with ADHD symptoms. HADS-A was an independent predictive factor for clinically significant symptoms of inattention ( p < 0.001) and hyperactivity/impulsivity ( p = 0.04) by logistic regression. Conclusion Inactive SLE patients, particularly those who had previous cerebral lupus, had more clinically significant symptoms of inattention but not hyperactivity/impulsivity reflecting underlying cognitive impairment. Anxiety and depressive symptoms were common confounders for ADHD-like symptoms.
Prevention of Lower Extremity Injuries in Basketball
Authors: Taylor Jeffrey B. , Ford Kevin R. , Nguyen Anh-Dung , Terry Lauren N. , Hegedus Eric J. 
Published: June 2015

Context: Lower extremity injuries are common in basketball, yet it is unclear how prophylactic interventions affect lower extremity injury incidence rates. Objective: To analyze the effectiveness of current lower extremity injury prevention programs in basketball athletes, focusing on injury rates of (1) general lower extremity injuries, (2) ankle sprains, and (3) anterior cruciate ligament (ACL) tears. Data Sources: PubMed, MEDLINE, CINAHL, SPORTDiscus, and the Cochrane Register of Controlled Trials were searched in January 2015. Study Selection: Studies were included if they were randomized controlled or prospective cohort trials, contained a population of competitive basketball athletes, and reported lower extremity injury incidence rates specific to basketball players. In total, 426 individual studies were identified. Of these, 9 met the inclusion criteria. One other study was found during a hand search of the literature, resulting in 10 total studies included in this meta-analysis. Study Design: Systematic review and meta-analysis. Level of Evidence: Level 2. Data Extraction: Details of the intervention (eg, neuromuscular vs external support), size of control and intervention groups, and number of injuries in each group were extracted from each study. Injury data were classified into 3 groups based on the anatomic diagnosis reported (general lower extremity injury, ankle sprain, ACL rupture). Results: Meta-analyses were performed independently for each injury classification. Results indicate that prophylactic programs significantly reduced the incidence of general lower extremity injuries (odds ratio [OR], 0.69; 95% CI, 0.57-0.85; P < 0.001) and ankle sprains (OR, 0.45; 95% CI, 0.29-0.69; P < 0.001), yet not ACL ruptures (OR, 1.09; 95% CI, 0.36-3.29; P = 0.87) in basketball athletes. Conclusion: In basketball players, prophylactic programs may be effective in reducing the risk of general lower extremity injuries and ankle sprains, yet not ACL injuries.
Esophageal stricture caused by rib osteoma in a cat: case report
Authors: Cunha Simone CS , Corgozinho Katia B , Martins Mauro C , Ferreira Ana MR 
Published: June 2015

Case summary A 6-year-old male domestic shorthair cat presented with frequent food regurgitation and dysphagia. Plain thoracic radiographs revealed a calcified mass overlying the topography of the mediastinum, as well as dilation of the cervical portion of the esophagus due to an accumulation of food. Endoscopic examination showed a severe extraluminal esophageal stricture at the mediastinum entrance. Surgery and a gastric tube were declined by the cat’s owner, with palliative support preferred. However, 1 year later, the cat presented with severe cachexia, dysphagia, salivation, dehydration and inspiratory dyspnea. Thoracic computed tomography was performed to evaluate the possibility of surgical resection. A mass of bone density originating in the second left rib was observed. The mass did not appear to have invaded adjacent structures but marked compression of the mediastinal structures was observed. Surgical resection was performed and a prosthetic mesh was used to reconstruct the thoracic wall. Transient Horner’s syndrome developed in the left eye postoperatively, and was resolved within 4 weeks. Histopathology revealed a benign osteoma. Thirty-two months after surgery, the cat was well and free of disease. Relevance and novel information Rib tumors should be included in a differential diagnosis in cats with extraluminal esophageal stricture. CT should be performed for treatment planning. Surgical treatment was curative in this case.
Neuroendocrine pituitary macroadenoma of a cat presenting with primary adipsia and hypernatraemia
Authors: Miller Rachel L , Bell Rory , Matiasek Kaspar , Rosati Marco , Housley Daniel , Palus Viktor 
Published: June 2015

Case summary A male neutered Ragdoll cat aged 11 years and 9 months presented with a 6 month history of weight loss and a 1 month history of lethargy and adipsia. A thorough clinical investigation confirmed a diagnosis of primary adipsia and hypernatraemia secondary to a non-secretory neuroendocrine pituitary macroadenoma. Relevance and novel information Primary adipsia is a very rare clinical entity. This report is the first to describe primary adipsia secondary to a non-secretory pituitary macroadenoma in the cat. The veterinary literature available in this field is very limited and this report adds a new differential diagnosis for cats presenting with primary hypodipsia.
Safety and activity of BTK inhibitor ibrutinib combined with ofatumumab in chronic lymphocytic leukemia: a phase 1b/2 study
Authors: Jaglowski Samantha M. , Jones Jeffrey A. , Nagar Veena , Flynn Joseph M. , Andritsos Leslie A. , Maddocks Kami J. , Woyach Jennifer A. , Blum Kristie A. , Grever Michael R. , Smucker Kelly , Ruppert Amy S. , Heerema Nyla A. , Lozanski Gerard , Stefanos Mona , Munneke Brian , West Jamie-Sue , Neuenburg Jutta K. , James Danelle F. , Hall Nathan , Johnson Amy J. , Byrd John C. 
Published: June 2015

Key PointsIbrutinib combined with ofatumumab in relapsed CLL had had an ORR of 83% with median time to response of <3 months in all groups. All 3 sequences of administration were acceptably tolerated and active; responses were durable, and median PFS was not yet reached.
AKR1C3 is a biomarker of sensitivity to PR-104 in preclinical models of T-cell acute lymphoblastic leukemia
Authors: Moradi Manesh Donya , El-Hoss Jad , Evans Kathryn , Richmond Jennifer , Toscan Cara E. , Bracken Lauryn S. , Hedrick Ashlee , Sutton Rosemary , Marshall Glenn M. , Wilson William R. , Kurmasheva Raushan T. , Billups Catherine , Houghton Peter J. , Smith Malcolm A. , Carol Hernan , Lock Richard B. 
Published: June 2015

Key PointsPR-104 represents a potential novel treatment for relapsed/refractory T-ALL. AKR1C3 expression could be used as a biomarker to select patients who may respond to PR-104 in prospective clinical trials.
The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth
Authors: Chang Leo , Kreko-Pierce Tabita , Eaton Benjamin A. 
Published: June 2015

ABSTRACT
The generation of neuronal morphology requires transport vesicles originating from the Golgi apparatus (GA) to deliver specialized components to the axon and dendrites. Drosophila Arfaptin is a membrane-binding protein localized to the GA that is required for the growth of the presynaptic nerve terminal. Here we provide biochemical, cellular and genetic evidence that the small GTPase Arl1 and the guanine-nucleotide exchange factor (GEF) Gartenzwerg are required for Arfaptin function at the Golgi during synapse growth. Our data define a new signaling pathway composed of Arfaptin, Arl1, and Garz, required for the generation of normal synapse morphology.
The homeodomain transcription factor Phox2 in the stellate ganglion of the squidLoligo pealei
Authors: Burbach J. Peter H. , Hellemons Anita J. C. G. M. , Grant Philip , Pant Harish C. 
Published: June 2015

ABSTRACTHomeodomain transcription factors regulate development of embryos and cellular physiology in adult systems. Paired-type homeodomain genes constitute a subclass that has been particularly implicated in establishment of neuronal identity in the mammalian nervous system. We isolated fragments of eight homeodomain genes of this subclass expressed in the stellate ganglion of the North Atlantic long finned squid Loligo pealei (lp) [Note: Loligo pealei has been officially renamed Doryteuthis pealei. For reasons of uniformity and clarity Loligo pealei (lp) is used here]. Of the most abundant ones, we cloned a full length cDNA which encoded the squid ortholog of the paired-type homeodomain proteins Phox2a/b. The homology of lpPhox2 to invertebrate and mammalian Phox2 was limited to the homeodomain. In contrast to mouse Phox2b, lpPhox2 was unable to transactivate the dopamine beta-hydroxylase (DBH) promoter in a heterologous mammalian transfection system. In vivo, lpPhox2 was expressed in the developing stellate ganglion of stage 27 squid embryos and continued to be expressed in the adult stellate neurons where expression was confined to the giant fiber lobe containing the neurons that form the giant axons. The expression of lpPhox was similarly timed and distributed as the Fmrf gene. Furthermore, the Fmrf upstream region contained putative Phox2a/b binding sites. These results suggest a role of lpPhox2 in the developmental specification of neuronal identity and regulation of neurons of the squid giant axon.
Abducing chances: Evolution, cognitive niches and hybrid humans as chance discoverers
Authors: Magnani Lorenzo 
Published: June 2015

Abstract
Humans continuously delegate and distribute cognitive functions to the environment to lessen their limits. They build models, representations and other various mediating structures that are considered to aid thought. In doing these, humans are engaged in a process of cognitive niche construction. In this sense, I argue that a cognitive niche emerges from a network of continuous interplays between individuals and the environment, in which people alter and modify the environment by mimetically externalizing eeting thoughts, private ideas, etc., into external supports. Through mimetic activities humans create external semiotic anchors that are the result of a process in which concepts, ideas and thoughts are projected onto external structures. Once concepts and thoughts are externalized and projected, new chances and ways of inferring come up from the blend. For cognitive niche construction may also contribute to making available a great portion of chances – in terms of information and knowledge – that otherwise would remain simply unexpressed or unreachable. The central part of this article will illustrate that abduction – or reasoning to explanatory hypotheses – is also central to understanding some features of the problem of action and decision-making. Abduction prompts new affordances and subsequent possible actions and plays a key role in decision-making, as C. S. Peirce teaches: the eco-neurological perspective depicted in this article also increases knowledge about the distinction between thought and motor action, seeing both aspects as fruit of brain activity. We can say that thought possesses an essential ‘motor’ component reflected in brain action but not in actual movement. On the basis of this analysis I can further illustrate some problems related to the role of abducting chances in decision-making, both in deliberate and unconscious cases.
Chemical darkrooms: Three architectural design experiments for surreal metamorphoses of body and photography
Authors: Loizos Yorgos 
Published: June 2015

Abstract
Central to my research is the collapse of nature, technology and the human body as a both creative and critical way for speculating architectures of constant change. Photography and film have been essential for recording these changes, and in many cases these arts have even allowed to register a world beyond our perception. The article focuses on Surrealist artist Man Ray and his contemporary artists, photographers and film-makers who saw the chemical photography’s potential through the alchemic transformation of light and dark throughout their devices, films and darkroom methods. In parallel the article links with architectural design and theory, with a series of design experiments through chemical photographic and analogue processes, to challenge and re-inspire a more contemporary digital architecture. This article will investigate chemical photography of its variable density and indices as a new form of constructing architectures. How the wet process of chemical photography could advance in such a way that could become architectural, and by exploring the light and temperature sensitive aspect of space, will evoke its constant transmutation and openness to chance.
Rationality and rupture
Authors: Trafford James 
Published: June 2015

Abstract
Any thought which is true to the contemporary must, seemingly, recognize the complex ecologies of human and non-human assemblages, algorithms, data structures, planetary climate change and so on. In this setting, it is unsurprising that there has been a recent shift towards consideration of basic questions of ontology and epistemology in order to attempt some traction on this terrain. In much of this, however, we find a constructed caricature of both reason and intuition, in which reason is reduced to the algorithmic by means of a recursively axiomatized formal system for the enumeration of all truths in a structure. Here, I suggest that this is a poor shadow of rationality that is rooted in a static, classical ‘image of thought’, and that many attempts to construct a category in excess of reason end up with an ossification and metastatization of intuition at the loss of any criticality and epistemic mediation. This article provides an attempt to undermine these views from within the caricature itself. In so doing, we consider a form of rationality capable of gaining traction on the shifting sands of the quasi-transcendental structure of experience, through the rehabilitation of abstraction as a process of navigational dialogue and transformation.
The shape of the void
Authors: Pendrell Luke 
Published: June 2015

Abstract
Geographies and the territories that opportunistically spring up to inhabit them, populate their landscapes and exploit their riches are merely superficial manifestations of more substratal tendencies of movement. What appears stable and static is, in fact, volatile, mutable, unstable. Coastal erosion, whether attributed to climate change or less anthropocene causes, can be read as a hyper-accelerated manifestation of geological time on a human scale. The processes of geological change, measured out in millennia and thus ordinarily imperceptible to the evanescent oscillations of human mortality, and the imaginations seated therein are dromologically condensed to a scale measurable in months or years. This sudden access or awareness, or maybe confluence between human and geological time, gives us a glimpse into the scales of the universe normally incomprehensible, and in doing so a glimpse too of our fragility and ephemerality. This article in itself ‘a quantity of faded images accompanied by only partial notations’ explores the way in which the tools and apparatuses we use to interrogate the detritus of both past and the present are unstable, mutable and often inadequate.
Rupture and reparation: Postmemory, the child seer and graphic violence in Infancia clandestina (Benjamín Ávila, 2012)
Authors: Thomas Sarah 
Published: June 2015

Abstract
Although films representing violence through a child’s eyes have become increasingly commonplace in Latin American cinema of the last three decades, this article proposes that Bejamín Ávila’s 2012 Infancia clandestina provides an innovative approach. The film emphasizes ruptures – aesthetic, thematic and spectatorial – as well as gestures towards their repair in an attempt to represent the child’s perspective and engage the viewer in approaching the nation’s violent past. These forms of rupture and reparation, along with oscillations between identification with and distance from the protagonist’s perspective, draw attention not only to the complexities of representing the child’s subjective viewpoint but also of representing the violence of state repression. After examining the film’s treatment of postmemorial generational rupture, the article explores the mechanisms by which the film aligns the viewer with the perspective of its child protagonist while refusing complete identification with his subject position. Finally, it demonstrates how the child’s perspective of violence is cast as unique – underscoring his difference and questioning the possibility of representing ‘realistically’ the violence of the Dirty War years.
A Male-Specific Genetic Map of the MicrocrustaceanDaphnia pulexBased on Single-Sperm Whole-Genome Sequencing
Authors: Xu Sen , Ackerman Matthew S , Long Hongan , Bright Lydia , Spitze Ken , Ramsdell Jordan S , Thomas W Kelley , Lynch Michael 
Published: June 2015

AbstractGenetic linkage maps are critical for assembling draft genomes to a meaningful chromosome level and for deciphering the genomic underpinnings of biological traits. The estimates of recombination rates derived from genetic maps also play an important role in understanding multiple aspects of genomic evolution such as nucleotide substitution patterns and accumulation of deleterious mutations. In this study, we developed a high-throughput experimental approach that combines fluorescence-activated cell sorting, whole-genome amplification, and short-read sequencing to construct a genetic map using single-sperm cells. Furthermore, a computational algorithm was developed to analyze single-sperm whole-genome sequencing data for map construction. These methods allowed us to rapidly build a male-specific genetic map for the freshwater microcrustacean Daphnia pulex, which shows significant improvements compared to a previous map. With a total of mapped 1672 haplotype blocks and an average intermarker distance of 0.87 cM, this map spans a total genetic distance of 1451 Kosambi cM and comprises 90% of the resolved regions in the current Daphnia reference assembly. The map also reveals the mistaken mapping of seven scaffolds in the reference assembly onto chromosome II by a previous microsatellite map based on F2 crosses. Our approach can be easily applied to many other organisms and holds great promise for unveiling the intragenomic and intraspecific variation in the recombination rates.