bluuebunny/crossref_metadata_2025_split huggingface dataset:
“From surviving to thriving” next steps for international graduate students: A call to action
Authors: Koo Katie , Bista Krishna , Al‐Sharif Mary Ann Bodine 
Published: August 2024

AbstractThis article discusses various ways for student affairs professionals, faculty, educators, and policymakers to contribute to the personal, academic, and professional development of international graduate students in the U.S. higher education within their functional areas and their expertise. By highlighting the culturally sensitive support and method in which diverse professionals can provide support for various dimensions of international graduate students’ experiences, this article offers practical insights for staff and educators working on college campuses in the current globalized era.
Diagnostic study on major honeybee disease, pests and predators in North Western Ethiopia
Authors: Shitaneh Esubalew , Arega Habtie , Bezabeh Amssalu 
Published: August 2024

AbstractBackgroundThe study was conducted in Pawe district from Benishangul‐Gumuz and Jawi and Fagita Lekoma districts from the Amhara region to investigate major honeybee pests, predators and diseases.MethodsUsing a purposive sampling technique, 183 households were interviewed, and 240 samples were collected for laboratory analysis of bee disease; data were analysed using descriptive statistics.ResultsThe share of hive types owned by sampled respondents was 88.6%; overall, 1.1% and 10.3% were traditional, transitional and modern beehives, respectively. About 92% of the sample respondents acquired their base colonies by catching swarm bees on the apex of trees. The majority of beekeepers executed external inspections of their colony, whereas only 50% carried out internal inspections. Based on the responses of beekeepers, around 48.9%, 56.3% and 23.1% of colonies absconded every year from Pawe, Jawi and Fagita Lekoma districts, respectively. Ants, wax moths, bee lice, beetles, spiders, birds, monkeys and honey badgers were the major honeybee pests and predators discovered in study areas in decreasing order. Concerning the incidence of Varroa mites, Nosema apis and amoeba disease, 27.5%, 60% and 71.6% of samples showed positive results in study locations, respectively.ConclusionsFrom this result, we observed that ants, wax moths, bee lice, beetles, spiders, birds, monkeys and honey badgers were the major honeybee pests and predators. The prevalence of amoeba disease was comparatively higher in highland areas and in the summer season. This finding suggests the need for the alertness of beekeepers in controlling bee disease and pests and strengthening bee colonies through seasonal colony management. There should be a strict quarantine, and check‐up undertaken when a new colony is purchased from one region to another is essential.
Study on Smoke Control of Tunnel Fire Under the Synergistic Effect of Longitudinal Ventilation and Top Exhaust System
Authors: Yao Guanghui , Liang Chenchen , Xu Mengyi , Yuan Zhongyuan 
Published: August 2024

AbstractIn order to establish a smoke-free and secure evacuation environment in long tunnels during fire incidents, while ensuring efficient utilization of fan equipment. We focus on the critical situation where smoke is just able to be completely discharged from the vent under the combined system of longitudinal ventilation and top exhaust. We establish a full-scale three-dimensional numerical computational model using FDS to investigate the impact of various factors on the critical complete exhaust volumetric flow rate of the exhaust system, including the heat release rate (HRR), the location of the longitudinal fire source, and the length of the exhaust vent. The findings indicate that an increase in heat release rate leads to a higher critical complete exhaust volumetric flow rate. Additionally, as the fire source moves away from the vent, there is a decrease in critical exhaust rate. Moreover, increasing the length of the smoke vent tends to initially increase and then decrease the critical exhaust rate. This study aims to provide guidance on determining the appropriate design values for exhaust volumetric flow rate in combined exhaust systems within long tunnels.
Experimental Study on the Influence of Expansion Agents and Fibers on the Dry Shrinkage Performance of Concrete
Authors: Ge Tao , Wu Han 
Published: August 2024

AbstractIn order to study the influence of expansion agents and fibers on the dry shrinkage of concrete, this paper designed and implemented dry shrinkage tests on plain concrete and various fiber reinforced concrete after adding expansion agents, as well as dry shrinkage tests on concrete with different lengths and types of fibers added. The mechanism of the influence of fibers and expansion agents on the dry shrinkage performance of concrete was revealed. The experimental results show that expansion agents have an improvement effect on the dry shrinkage performance of various types of concrete, while fibers have varying effects on the dry shrinkage of concrete due to their length and equivalent diameter. The research results have guiding significance on how to improve the dry shrinkage performance of concrete.
Comparative Study on Chinese and Foreign Earth Pressure Calculation Methods for Pipe-Sheet Composite Wharf Structure
Authors: Chen Hongwei , Zhang Jinghong , Mei Taotao , Niu Fei 
Published: August 2024

AbstractPipe-sheet combination structure is a novel form of wharf structure, which utilizes steel pipe piles with better performance as the main stress components to withstand lateral pressures such as water pressure and earth pressure, and low-cost steel sheet piles as the linking structure to form a pipe-sheet combination wall, which to a certain extent can take into account both the performance and the cost issues, but whether the pipe-sheet combination structure can be adapted to the design and use of the large-scale berths of the wharf under the deep-water environment has always been a controversial issue in the engineering field. However, it has been controversial in the engineering community. Therefore, it is necessary to analyze and research more deeply the actual force situation of the pipe-sheet combination structure and the applicable calculation method. In this paper, based on the field measurement data, the active earth pressure calculation of the back side of the pipe-sheet composite pile is compared and analyzed, and the results show that the earth pressure calculation formulas used in China and the United States for the sheet pile structure are much closer to the actual results compared to the calculation method of the Japanese specification in the calculation of the earth pressure of the back side of the pipe-sheet composite structure; the numerical simulation can be used to set up the pipe-sheet composite pile structure into an equivalent cross-section of the sheet pile module, which can effectively avoid the data of the sheet pile module, and can also be used in the numerical simulation. When numerical simulation is used, the pipe-sheet composite structure can be set up as a plate pile module with equivalent cross-section, which can effectively avoid the problems of aberration and stress concentration in the data calculation, and the calculation results can better respond to the actual stress situation in the field.
Quantifying Uncertainties in Model Updating Following Bayesian Approach Using a Parameter Space-Search Algorithm
Authors: Yang Jiahua , Zheng Yi 
Published: August 2024

AbstractModel updating aims to provide accurate models to reveal possible structural damage information for structural health monitoring (SHM). Uncertainties always exist in model updating due to incomplete information in measurement and modeling. These uncertainties usually cause the problem of non-uniqueness, i.e., multiple equivalent models can fit the experimental data the same well. Locating all these equivalent models and including them for representing structural dynamics is a challenging task. This work employs a Bayesian probabilistic framework for model updating, so that the uncertainties can be quantified, and thus all of the multiple equivalent models can be considered naturally. A parameter space-search algorithm is proposed to systematically locate all the equivalent models. A transmission tower under laboratory conditions with limited modal parameters was used to valid the proposed method.
Dissipative fracton superfluids
Authors: Głódkowski Aleksander , Peña-Benítez Francisco , Surówka Piotr 
Published: August 2024

Abstract
We present a comprehensive study of hydrodynamic theories for superfluids with dipole symmetry. Taking diffusion as an example, we systematically construct a hydrodynamic framework that incorporates an intrinsic dipole degree of freedom in analogy to spin density in micropolar (spinful) fluids. Subsequently, we study a dipole condensed phase and propose a model that captures the spontaneous breaking of the U(1) charge. The theory explains the role of the inverse Higgs constraint for this class of theories, and naturally generates the gapless field. Next, we introduce finite temperature theory using the Hamiltonian formalism and study the hydrodynamics of ideal fracton superfluids. Finally, we postulate a derivative counting scheme and incorporate dissipative effects using the method of irreversible thermodynamics. We verify the consistency of the dispersion relations and argue that our counting is systematic.
The Current Evidence and How-To on Combined Sacrocolpopexy and Rectopexy
Authors: Gee Amy D. , Lee Sunny Kairi , Ban Kristen , Paraiso Marie Fidela R. 
Published: August 2024

Abstract
Introduction and Hypothesis
Multicompartment prolapse is a complex pelvic floor condition that can involve coordination of both urogynecologists and colorectal surgeons.

Methods
Concomitant sacrocolpopexy and ventral rectopexy is a safe and effective approach to treating this condition.

Results
The combined procedure has high rates of patient satisfaction and symptom improvement, including defecatory dysfunction, sexual health, and overall increased quality of life.

Conclusion
Concomitant sacrocolpopexy with ventral rectopexy is safe and improves overall outcomes.
Mapping small metabolite changes after traumatic brain injury using AP-MALDI MSI
Authors: Siciliano Angela Marika , Moro Federico , De Simone Giulia , Pischiutta Francesca , Morabito Aurelia , Pastorelli Roberta , Brunelli Laura , Zanier Elisa R. , Davoli Enrico 
Published: August 2024

AbstractTraumatic brain injury (TBI) is an alteration of brain function caused by a sudden transmission of an external force to the head. The biomechanical impact induces acute and chronic metabolic changes that highly contribute to injury evolution and outcome. TBI heterogeneity calls for approaches allowing the mapping of regional molecular and metabolic changes underpinning disease progression, with mass spectrometry imaging (MSI) as an efficient tool to study the spatial distribution of small metabolites. In this study, we applied an innovative targeted atmospheric pressure-MALDI mass spectrometry imaging (AP-MALDI MSI) approach, starting from an extensive list of metabolites, representative of different metabolic pathways, individually validated on the tissue under analysis with original standards using 2,5-dihydroxybenzoic acid (DHB), to characterize the impact of TBI on regional changes to small metabolites in the brain. Brains from sham and TBI mice obtained 21 days post-injury were analyzed to examine the spatial metabolic profile of small metabolites belonging to different metabolic pathways. By a whole brain analysis, we identified four metabolites (alanine, lysine, histidine, and inosine) with higher abundance in TBI than sham mice. Within the TBI group, lysine, histidine, and inosine were higher in the hemisphere ipsilateral to the biomechanical impact vs. the contralateral one. Images showed a major involvement of the ipsilateral thalamus characterized by the increase of arginine, lysine, histidine, and inosine and a significant reduction of glutamic acid, and N-acetylaspartic acid compared to the contralateral thalamus. These findings indicate high-resolution imaging mass spectrometry as a powerful tool to identify region-specific changes after a TBI to understand the metabolic changes underlying brain injury evolution.
Evaluation of treatment response with serial CT in patients with non-tuberculous mycobacterial pulmonary disease
Authors: Dettmer Sabine , Heiß-Neumann Marion , Wege Sabine , Maske Hannah , Ringshausen Felix C. , Joean Oana , Theissig Nicole , Ewen Raphael , Wacker Frank , Rademacher Jessica 
Published: August 2024

Abstract

Objectives
In patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD), the response to treatment is evaluated based on microbiological, clinical, and radiological data. However, little is known about the dynamics of CT findings. The aim of this study was to evaluate CT changes in NTM-PD in order to define radiological criteria for treatment success.

Methods
Retrospective multicenter study (Hannover, Heidelberg, Gauting). Sixty patients with NTM-PD and at least two consecutive CT scans were included. Scoring for NTM-PD was performed by evaluating variables of bronchiectasis, mucus plugging, bronchiolitis, cavities, nodules, and consolidations on an ordinal scale from 0 to 3. Differences between baseline and follow-up were calculated, and patients with/without cultural conversion were compared using the Mann–Whitney U-test. For paired comparison of the two consecutive CT scans the Wilcoxon test was used.

Results
Comparing patients with and without culture conversion, there were significant differences in temporal changes of bronchiectasis (p < 0.001), cavities (p = 0.006), bronchiolitis (p < 0.001), consolidations (p = 0.004), and total score (p < 0.001). Nodules showed no significant differences between groups (p = 0.060). The Wilcoxon test showed significant differences between both CTs in patients with a microbiological cure for the total score (p < 0.001), cavities (p = 0.005), bronchiolitis (p < 0.001), and consolidations (p = 0.021) with a decrease after microbiological cure, whereas bronchiectasis (p = 0.102) and nodules (p = 0.18) stayed stable. In the case of persistently positive cultures, there was an increase in the total score (p = 0.010) which was attributable to progressive bronchiectasis (p < 0.001).

Conclusion
Cavities, consolidations, and bronchiolitis are useful to assess treatment response, whereas bronchiectasis and nodules may remain stable despite successful treatment.

Clinical relevance statement
Cavities, consolidations, and bronchiolitis can assess treatment response whereas bronchiectasis and nodules may remain stable despite successful treatment. In persistently positive cultures, bronchiectasis showed an increase over time indicating that NTM-PD is a progressive chronic disease.

Key Points

Little is known about CT changes in nontuberculous mycobacteria pulmonary disease (NTM-PD) and criteria to evaluate treatment response.

In the case of culture conversion, cavities and bronchiolitis decreased whereas bronchiectasis and nodules remained stable.

Cavities and bronchiolitis can evaluate treatment response in NTM, but bronchiectasis and nodules may persist despite successful treatment.
Evaluation of RegCM simulation ensemble using different parameterization scheme combinations: a case study for an extremely wet year in the Carpathian region
Authors: Kalmár Tímea , Pongrácz Rita , Pieczka Ildikó , Hollós Roland 
Published: August 2024

AbstractDue to its high influence on agriculture, infrastructure, water management, and other areas, precipitation is one of the most important climate factors. However, it is still challenging for climate models to realistically reproduce regional patterns, temporal variability, and precipitation intensity. This is especially true for extreme conditions and terrains with heterogeneous orography, like the Carpathian region.For the sake of quantifying the uncertainty and improving the accuracy of the precipitation simulations of the RegCM4.7 regional climate model over the Carpathian region, we evaluate the performance of different options at 10 km horizontal resolution, using ERA-Interim reanalysis data as initial and boundary conditions. Altogether 24 simulations were carried out by using various combinations of the physical schemes (2 land surface, 2 microphysics, 3 cumulus convection and 2 planetary boundary layer (PBL) schemes) for the year 2010, which was the wettest year in the Carpathian region (especially in Hungary) since 1901. Different parameterization combinations lead to different simulated climates, so their variance can serve as an estimate of model uncertainty due to the representation of unresolved phenomena.The results show that RegCM is sensitive to the choice of scheme combinations. The analysis of the RegCM4.7 ensemble indicates systematic precipitation biases, which are linked to different physical mechanisms in the summer and winter seasons. Based on the results, RegCM4.7 is the most sensitive to the applied convection scheme, but the interactions with the other schemes (e.g., land surface and microphysics) affect the convective and large-scale precipitation in addition to the total precipitation.
Feasibility of a tailored operative strategy from organ preservation to pelvic exenteration for cT4 rectal cancer depending on neoadjuvant response
Authors: Fleming Christina , Harji Deena , Fernandez Benjamin , François Marc-Olivier , Assenat Vincent , Gilles Pasticier , Clément Michiels , Robert Grégoire , Denost Quentin 
Published: August 2024

Abstract
Purpose
Improvements in neoadjuvant therapy for locally advanced cT4 rectal cancer have led to improved tumour response and thus a variety of suitable management strategies. The aim of this study was to report management and outcomes of patients with cT4 rectal cancer undergoing a spectrum of treatment strategies from organ preservation (OP) to pelvic exenteration (PE).

Methods
Patients who underwent elective treatment for cT4 rectal cancer between 2016 and 2021 were included. All patients were treated with curative intent. Surgical management was adapted to tumour response. Kaplan–Meier curves were generated to compare 3-year overall survival (3y-OS), local recurrence (3y-LR) and distant metastases (3y-DM) between different strategies.

Results
Among 152 patients included, 13 (8%) underwent OP, 71 (47%) TME and 68 (45%) APR/PE. The median follow-up was 31.3 months. Patients undergoing OP had a lower tumour pretreatment (p < 0.001). Compared to patients with TME, those with APR/PE had a higher rate of ypT4 (p = 0.001) with a lower R0 rate (p = 0.044). The 3y-OS and 3y-DM were 78% and 15.1%, respectively, without significant differences. The 3y-LR was 6.6%, and patients with OP had a significantly worse 3y-local regrowth compared to 3y-LR in patients with TME and APR/PE (30.2% vs. 5.4% vs. 2%, p = 0.008).

Conclusion
cT4 tumours may be suitable for the full spectrum of rectal cancer management from organ preservation to pelvic exenteration depending on tumour response to neoadjuvant therapy. However, careful attention is required in OP as local regrowth in up to 30% of cases reinforces the need for sustained active surveillance in Watch&Wait programmes.
The parkin V380L variant is a genetic modifier of Machado–Joseph disease with impact on mitophagy
Authors: Weber Jonasz J. , Czisch Leah , Pereira Sena Priscila , Fath Florian , Huridou Chrisovalantou , Schwarz Natasa , Incebacak Eltemur Rana D. , Würth Anna , Weishäupl Daniel , Döcker Miriam , Blumenstock Gunnar , Martins Sandra , Sequeiros Jorge , Rouleau Guy A. , Jardim Laura Bannach , Saraiva-Pereira Maria-Luiza , França Marcondes C. , Gordon Carlos R. , Zaltzman Roy , Cornejo-Olivas Mario R. , van de Warrenburg Bart P. C. , Durr Alexandra , Brice Alexis , Bauer Peter , Klockgether Thomas , Schöls Ludger , Riess Olaf ,   The EUROSCA Network, Bauer Peter , Berciano José , Boesch Sylvia , Brice Alexis , Durr Alexandra , Forlani Sylvie , Giunti Paola , Jacobi Heike , Klockgether Thomas , Melegh Bela , Pandolfo Massimo , Riess Olaf , Schmitz-Hübsch Tanja , Schöls Ludger , Schulz Jörg B. , Stevanin Giovanni , Szymanski Sandra , Tezenas du Montcel Sophie , Timmann Dagmar , van de Warrenburg Bart P. C. , Schmidt Thorsten 
Published: August 2024

AbstractMachado–Joseph disease (MJD) is an autosomal dominant neurodegenerative spinocerebellar ataxia caused by a polyglutamine-coding CAG repeat expansion in the ATXN3 gene. While the CAG length correlates negatively with the age at onset, it accounts for approximately 50% of its variability only. Despite larger efforts in identifying contributing genetic factors, candidate genes with a robust and plausible impact on the molecular pathogenesis of MJD are scarce. Therefore, we analysed missense single nucleotide polymorphism variants in the PRKN gene encoding the Parkinson's disease-associated E3 ubiquitin ligase parkin, which is a well-described interaction partner of the MJD protein ataxin-3, a deubiquitinase. By performing a correlation analysis in the to-date largest MJD cohort of more than 900 individuals, we identified the V380L variant as a relevant factor, decreasing the age at onset by 3 years in homozygous carriers. Functional analysis in an MJD cell model demonstrated that parkin V380L did not modulate soluble or aggregate levels of ataxin-3 but reduced the interaction of the two proteins. Moreover, the presence of parkin V380L interfered with the execution of mitophagy—the autophagic removal of surplus or damaged mitochondria—thereby compromising cell viability. In summary, we identified the V380L variant in parkin as a genetic modifier of MJD, with negative repercussions on its molecular pathogenesis and disease age at onset.
Impact of response to neoadjuvant chemotherapy on surgical modality in patients with T1-2N0-1M0 triple-negative breast cancer
Authors: Chang Lidan , Liu Dandan , Hao Qian , Ren Xueting , Liu Peinan , Liu Xingyu , Wei Yumeng , Lin Shuai , Ma Xiaobin , Wu Hao , Kang Huafeng , Wang Meng 
Published: August 2024

Abstract
Purpose
Many T1-2N0-1M0 triple-negative breast cancer (TNBC) patients who undergo neoadjuvant chemotherapy (NAC) do not receive breast-conserving therapy (BCT) due to concerns about non-pCR or lymph node metastasis presence.

Methods
T1-2N0-1M0 TNBC patients who underwent NAC between 2010 and 2017 were collected from the SEER database. Factors affecting surgical modalities were analyzed by multinomial logistic regression. The overall survival (OS) and breast cancer-specific survival (BCSS) were evaluated by Kaplan-Meier curves and Cox proportional hazards models. Further stratified subgroup analyses were performed based on the response to NAC and N-stage. Adjusted-hazard ratios were also calculated to exclude potential bias.

Results
A total of 1112 patients were enrolled (median follow-up: 81 months), 58.5% received BCT, 23.6% received reconstruction and 17.9% received mastectomy. Response to NAC and N-stage not only influenced the choice of surgical modality but also were independent predictors for OS and BCSS. The surgery-induced survival differences mainly affect OS. Survival analyses demonstrated that the 10-year OS of BCT was superior or equal to that of mastectomy even in patients with partial response (PR) (77.4% vs. 64.1%, P = 0.013), no response (NR) (44.9% vs. 64.2%, P = 0.33), or N1 stage (75.7% vs. 57.4%, P = 0.0021). In the N1-PR cohort, mastectomy may lead to worse OS (P = 0.0012). Besides, between reconstruction and BCT, there was no statistical difference in OS or BCSS (P > 0.05).

Conclusion
Our study reveals the necessity of breast surgical de-escalation. Besides, physicians should actively recommend reconstruction for individuals who strongly desire mastectomy.