bluuebunny/crossref_metadata_2025_split huggingface dataset:
Predictive Modeling of Hypertension-Related Postpartum Readmission: Retrospective Cohort Analysis
Authors: Tao Jinxin , Larson Ramsey G , Mintz Yonatan , Alagoz Oguzhan , Hoppe Kara K 
Published: June 2024

Background
Hypertension is the most common reason for postpartum hospital readmission. Better prediction of postpartum readmission will improve the health care of patients. These models will allow better use of resources and decrease health care costs.

Objective
This study aimed to evaluate clinical predictors of postpartum readmission for hypertension using a novel machine learning (ML) model that can effectively predict readmissions and balance treatment costs. We examined whether blood pressure and other measures during labor, not just postpartum measures, would be important predictors of readmission.

Methods
We conducted a retrospective cohort study from the PeriData website data set from a single midwestern academic center of all women who delivered from 2009 to 2018. This study consists of 2 data sets; 1 spanning the years 2009-2015 and the other spanning the years 2016-2018. A total of 47 clinical and demographic variables were collected including blood pressure measurements during labor and post partum, laboratory values, and medication administration. Hospital readmissions were verified by patient chart review. In total, 32,645 were considered in the study. For our analysis, we trained several cost-sensitive ML models to predict the primary outcome of hypertension-related postpartum readmission within 42 days post partum. Models were evaluated using cross-validation and on independent data sets (models trained on data from 2009 to 2015 were validated on the data from 2016 to 2018). To assess clinical viability, a cost analysis of the models was performed to see how their recommendations could affect treatment costs.

Results
Of the 32,645 patients included in the study, 170 were readmitted due to a hypertension-related diagnosis. A cost-sensitive random forest method was found to be the most effective with a balanced accuracy of 76.61% for predicting readmission. Using a feature importance and area under the curve analysis, the most important variables for predicting readmission were blood pressures in labor and 24-48 hours post partum increasing the area under the curve of the model from 0.69 (SD 0.06) to 0.81 (SD 0.06), (P=.05). Cost analysis showed that the resulting model could have reduced associated readmission costs by US $6000 against comparable models with similar F1-score and balanced accuracy. The most effective model was then implemented as a risk calculator that is publicly available. The code for this calculator and the model is also publicly available at a GitHub repository.

Conclusions
Blood pressure measurements during labor through 48 hours post partum can be combined with other variables to predict women at risk for postpartum readmission. Using ML techniques in conjunction with these data have the potential to improve health outcomes and reduce associated costs. The use of the calculator can greatly assist clinicians in providing care to patients and improve medical decision-making.
Implementing a Biomedical Data Warehouse From Blueprint to Bedside in a Regional French University Hospital Setting: Unveiling Processes, Overcoming Challenges, and Extracting Clinical Insight
Authors: Karakachoff Matilde , Goronflot Thomas , Coudol Sandrine , Toublant Delphine , Bazoge Adrien , Constant Dit Beaufils Pacôme , Varey Emilie , Leux Christophe , Mauduit Nicolas , Wargny Matthieu , Gourraud Pierre-Antoine 
Published: June 2024

Abstract

Background
Biomedical data warehouses (BDWs) have become an essential tool to facilitate the reuse of health data for both research and decisional applications. Beyond technical issues, the implementation of BDWs requires strong institutional data governance and operational knowledge of the European and national legal framework for the management of research data access and use.

Objective
In this paper, we describe the compound process of implementation and the contents of a regional university hospital BDW.

Methods
We present the actions and challenges regarding organizational changes, technical architecture, and shared governance that took place to develop the Nantes BDW. We describe the process to access clinical contents, give details about patient data protection, and use examples to illustrate merging clinical insights.

Implementation (Results)
More than 68 million textual documents and 543 million pieces of coded information concerning approximately 1.5 million patients admitted to CHUN between 2002 and 2022 can be queried and transformed to be made available to investigators. Since its creation in 2018, 269 projects have benefited from the Nantes BDW. Access to data is organized according to data use and regulatory requirements.

Conclusions
Data use is entirely determined by the scientific question posed. It is the vector of legitimacy of data access for secondary use. Enabling access to a BDW is a game changer for research and all operational situations in need of data. Finally, data governance must prevail over technical issues in institution data strategy vis-à-vis care professionals and patients alike.
Impact of an Electronic Health Record–Based Interruptive Alert Among Patients With Headaches Seen in Primary Care: Cluster Randomized Controlled Trial
Authors: Pradhan Apoorva , Wright Eric A , Hayduk Vanessa A , Berhane Juliana , Sponenberg Mallory , Webster Leeann , Anderson Hannah , Park Siyeon , Graham Jove , Friedenberg Scott 
Published: June 2024

Abstract

Background
Headaches, including migraines, are one of the most common causes of disability and account for nearly 20%‐30% of referrals from primary care to neurology. In primary care, electronic health record–based alerts offer a mechanism to influence health care provider behaviors, manage neurology referrals, and optimize headache care.

Objective
This project aimed to evaluate the impact of an electronic alert implemented in primary care on patients’ overall headache management.

Methods
We conducted a stratified cluster-randomized study across 38 primary care clinic sites between December 2021 to December 2022 at a large integrated health care delivery system in the United States. Clinics were stratified into 6 blocks based on region and patient-to–health care provider ratios and then 1:1 randomized within each block into either the control or intervention. Health care providers practicing at intervention clinics received an interruptive alert in the electronic health record. The primary end point was a change in headache burden, measured using the Headache Impact Test 6 scale, from baseline to 6 months. Secondary outcomes included changes in headache frequency and intensity, access to care, and resource use. We analyzed the difference-in-differences between the arms at follow-up at the individual patient level.

Results
We enrolled 203 adult patients with a confirmed headache diagnosis. At baseline, the average Headache Impact Test 6 scores in each arm were not significantly different (intervention: mean 63, SD 6.9; control: mean 61.8, SD 6.6; P=.21). We observed a significant reduction in the headache burden only in the intervention arm at follow-up (3.5 points; P=.009). The reduction in the headache burden was not statistically different between groups (difference-in-differences estimate –1.89, 95% CI –5 to 1.31; P=.25). Similarly, secondary outcomes were not significantly different between groups. Only 11.32% (303/2677) of alerts were acted upon.

Conclusions
The use of an interruptive electronic alert did not significantly improve headache outcomes. Low use of alerts by health care providers prompts future alterations of the alert and exploration of alternative approaches.
Bridging Data Models in Health Care With a Novel Intermediate Query Format for Feasibility Queries: Mixed Methods Study
Authors: Rosenau Lorenz , Gruendner Julian , Kiel Alexander , Köhler Thomas , Schaffer Bastian , Majeed Raphael W 
Published: June 2024

Abstract

Background
To advance research with clinical data, it is essential to make access to the available data as fast and easy as possible for researchers, which is especially challenging for data from different source systems within and across institutions. Over the years, many research repositories and data standards have been created. One of these is the Fast Healthcare Interoperability Resources (FHIR) standard, used by the German Medical Informatics Initiative (MII) to harmonize and standardize data across university hospitals in Germany. One of the first steps to make these data available is to allow researchers to create feasibility queries to determine the data availability for a specific research question. Given the heterogeneity of different query languages to access different data across and even within standards such as FHIR (eg, CQL and FHIR Search), creating an intermediate query syntax for feasibility queries reduces the complexity of query translation and improves interoperability across different research repositories and query languages.

Objective
This study describes the creation and implementation of an intermediate query syntax for feasibility queries and how it integrates into the federated German health research portal (Forschungsdatenportal Gesundheit) and the MII.

Methods
We analyzed the requirements for feasibility queries and the feasibility tools that are currently available in research repositories. Based on this analysis, we developed an intermediate query syntax that can be easily translated into different research repository–specific query languages.

Results
The resulting Clinical Cohort Definition Language (CCDL) for feasibility queries combines inclusion criteria in a conjunctive normal form and exclusion criteria in a disjunctive normal form, allowing for additional filters like time or numerical restrictions. The inclusion and exclusion results are combined via an expression to specify feasibility queries. We defined a JSON schema for the CCDL, generated an ontology, and demonstrated the use and translatability of the CCDL across multiple studies and real-world use cases.

Conclusions
We developed and evaluated a structured query syntax for feasibility queries and demonstrated its use in a real-world example as part of a research platform across 39 German university hospitals.
Effectiveness of 675-nm Wavelength Laser Therapy in the Treatment of Androgenetic Alopecia Among Indian Patients: Clinical Experimental Study
Authors: Chandrashekar BS , Lobo Oliver Clement , Fusco Irene , Madeddu Francesca , Zingoni Tiziano 
Published: June 2024

Background
Androgenetic alopecia (AGA) is the most prevalent cause of hair loss around the world.

Objective
The purpose of this study was to evaluate the efficacy of laser stimulation with a 675-nm wavelength for the treatment of AGA in male and female Indian patients.

Methods
A total of 20 Indian healthy patients aged 23-57 years who presented a grade of alopecia stage I to stage V underwent one single pass with a 675-nm laser to the scalp area twice a week for a total of 8 sessions, followed by once a week for 4 sessions and once in 2 weeks for 2 sessions. There are 14 laser treatments in total. Macro- and dermatoscopic images have been acquired at T0 (baseline) and T1 (4 months). The vertex, frontal, and parietal areas of the scalp were evaluated. Many parameters were analyzed including hair count and hair density of terminal; mean thickness; vellus follicles; total follicular units; units with 1 hair, 2 hairs, 3 hairs, 4 hairs, and >4 hairs; unit density; and average hair/unit.

Results
The macroimages and dermatoscopic evaluations showed good improvement over the entire treated area, with a clear increase in the number of hairs and hair thickness. General parameters such as hair count and hair density showed a percentage increase of around 17%. The hair mean thickness parameters showed a significant (P<.001) percentage increase of 13.91%. Similar results were obtained for terminal and vellus hair: terminal hair count and hair density significantly (P=.04 and P=.01, respectively) increased by 17.45%, vellus hair count increased by 16.67% (P=.06), and the density of vellus hair increased by 16.61% (P=.06).

Conclusions
The study findings demonstrate that the 675-nm laser system improved AGA in Indian patients, facilitating the anagen phase and improving hair density and other positive hair parameters.
Komodifikasi Kerajinan Anyaman Ata Sebagai Cenderamata
Authors: Ariningsih Ni Putu 
Published: June 2024

Kerajinan Anyaman ata merupakan oleh-oleh khas Desa Seraya Kabupaten Karangasem sebagai salah satu komponen budaya yang dapat dikunjungi wisatawan di Seraya. Kerajinan Anyaman ata yang diproduksi di Desa Seraya dijadikan oleh-oleh khas destinasi wisata di Kabupaten Karangasem. Anyaman ata awalnya digunakan untuk kebutuhan sehari-hari masyarakat pedesaan dan keperluan upacara keagamaan. Perkembangan pariwisata menyebabkan kerajinan anyaman ata di Desa Seraya bervariasi dan mengubah pola konsumsi tergantung permintaan konsumen. Komodifikasi mengubah aspek kehidupan bermasyarakat. Perubahan tersebut pada akhirnya memunculkan kreativitas untuk menciptakan kerajinan Anyaman ata yang sesuai dengan selera pasar dan permintaan konsumen dengan tujuan memperoleh keuntungan sebesar-besarnya. Ko-modifikasi mempengaruhi seni kriya dalam industri ata di Desa Seraya. Berdasarkan perkembangan tersebut permasalahan pokok yang dibahas adalah bagaimana proses komodifikasi oleh-oleh anyaman ata di Desa Seraya Kabupaten Karangasem. Teori-teori yang digunakan untuk membahas permasalahan tersebut adalah teori ko-modifikasi, teori perubahan sosial budaya konsumen. Dalam pemilihan informan digunakan metode “purposive sampling dan snowball”. Teknik analisis yang digunakan adalah deskriptif kualitatif dengan sifat induktif.

Anyaman ata craft is a typical souvenir of Seraya Village in Karangasem Regency as one of the cultural components that tourists can visit in Seraya. The woven ata craft produced in Seraya Village is made into a typical souvenir destination in Karangasem Regency. Initially used for the daily needs of rural communities and religious ceremonies, the ata weaving has evolved due to tourism development, varying based on consumer demand. The commodification has transformed societal aspects, leading to creativity in creating woven ata crafts that cater to market preferences and consumer demands to maximize profits. Commodification influences the craft industry in Seraya Village. The main issue discussed is the commodification process of ata woven souvenirs in Seraya Village, Karangasem Regency, using theories such as commodification theory and consumer socio-cultural change theory. The informant selection method includes purposive sampling and snowball technique, with a qualitative descriptive analysis approach of an inductive nature.
262-OR: Pemvidutide, a GLP-1/Glucagon Dual Receptor Agonist, in Subjects with Overweight or Obesity—A 48-Week, Placebo-Controlled, Phase 2 (MOMENTUM) Trial
Authors: ARONNE LOUIS , SCOTT HARRIS M. , ROBERTS M S. , SUSCHAK JOHN J. , TOMAH SHAHEEN , KASPER JONATHAN , HE LIANG , YANG JAY , FRIAS JUAN P. , BROWNE SARAH K. 
Published: June 2024

Introduction & Objective: Pemvidutide is a GLP-1/glucagon dual receptor agonist in development for treatment of obesity.
Methods: MOMENTUM was a Phase 2, randomized, placebo-controlled trial of subjects with overweight (BMI 27.0-29.9 kg/m2) and at least one obesity-related comorbidity or obesity (BMI &gt;30.0 kg/m2) randomized 1:1:1:1 to pemvidutide (1.2, 1.8, 2.4 mg) or placebo administered subcutaneously weekly for 48 weeks.
Results: A total of 391 subjects with mean age, body weight, and BMI of 50 yrs, 105 kg, and 37 kg/m2 were enrolled. At week 48, subjects receiving pemvidutide achieved mean weight losses of 10.3%, 11.2%, and 15.6% at the 1.2 mg, 1.8 mg, and 2.4 mg doses vs. placebo (2.2%), respectively (p&lt;0.001 vs. placebo, all doses, Figure 1), with 51.8% and 32.1% of subjects at the 2.4 mg dose level achieving ≥15% and ≥20% weight loss and 48% of subjects having resolution of baseline obesity by trial conclusion. Subjects with elevated serum lipids at baseline had reductions of up to 55.8%, 20.0%, and 21.8% in triglycerides, total cholesterol and LDL at week 48. Most adverse events were mild to moderate with only 1 drug-related SAE; glycemic control (glucose, HbA1c) was maintained with minimal increases in heart rate.
Conclusion: Pemvidutide was safe and well-tolerated and significantly reduced body weight and serum lipids over 48 weeks of treatment.

Disclosure
L. Aronne: Advisory Panel; Novo Nordisk. Consultant; Novo Nordisk. Advisory Panel; Lilly Diabetes, Altimmune Inc. Consultant; Lilly Diabetes. Advisory Panel; Pfizer Inc. Consultant; UnitedHealth Group. Advisory Panel; Boehringer-Ingelheim. Board Member; AstraZeneca. Advisory Panel; Amgen Inc. M. Harris: Employee; Altimmune Inc. M.S. Roberts: Employee; Altimmune Inc. J.J. Suschak: Employee; Altimmune Inc. S. Tomah: Employee; Altimmune Inc. J. Kasper: Employee; Altimmune Inc. L. He: None. J. Yang: None. J.P. Frias: Research Support; Akero Therapeutics, Inc. Consultant; Akero Therapeutics, Inc. Research Support; Altimmune Inc. Consultant; Altimmune Inc. Research Support; Boehringer-Ingelheim. Consultant; Boehringer-Ingelheim. Research Support; 89bio, Inc. Consultant; 89bio, Inc. Research Support; Eli Lilly and Company. Advisory Panel; Eli Lilly and Company. Speaker's Bureau; Eli Lilly and Company. Research Support; Merck & Co., Inc. Consultant; Merck & Co., Inc. Research Support; Novartis Pharmaceuticals Corporation. Consultant; Novartis Pharmaceuticals Corporation, Novo Nordisk. Board Member; Novo Nordisk. Research Support; Novo Nordisk, Pfizer Inc. Consultant; Pfizer Inc. Advisory Panel; Sanofi. Speaker's Bureau; Sanofi. Research Support; Sanofi. Stock/Shareholder; Biomea Fusion, Inc. Employee; Biomea Fusion, Inc. S.K. Browne: Employee; Altimmune Inc.
Evolution the Relationship Between Physiologically Equivalent Temperature and Some Meteorological Parameters for Basra City, Iraq
Authors: Al-Ramahy Zahraa A. 
Published: June 2024

Background: Physiologically equivalent temperatures (PET) is highly efficient in evaluating the thermal component of any given microclimate as a single thermal index. The assist stakeholders in understanding and interpreting existing bioclimatic, allowing them to make any required modifications and become more robust to predicted climate change. Objective: This study assesses the relationship between Physiologically equivalent temperatures (PET) and some Meteorological Parameters. Methods: The data for this study includes observed mean monthly air temperature values, relative humidity, and wind speed for the period (2001-2020). The data was acquired from “Iraqi Meteorological Organization and Seismology (IMOS)” stations for Basra city. The radiation and Human Bioclimatic (RayMan) model were used to simulate bioclimatic indices (SET, UTCI, PET, PMV). Results: The findings revealed that the greatest mean values for PMV (4.3), SET (36.3), PET (45.5), and UTCI (42.1) were seen in July and August. The measurements have a nice thermal sensation of PMV (-0.5 - 1.9), SET (19.2- 29), PET (18.1- 31.8), and UTCI (15.9 - 28.7) is most noticeable in the months of (March, April, and October). The results showed the PET values (cool) and (Slightly cool) between (9- 18.3) for January, February, March, and December. The value of UTCI was between (5.9- 8.5) within classes (Slight cold stress), the values of PMV (-2.6- (-2.1)) within classes (strong cold stress) and (Slight cold stress) and the value of SET was (10.2- 12.4) within classes (Slight cold stress). Conclusions: Correlations between PET and air temperature (0.99), indicating good agreement between PET and air temperature, and relative humidity (0.96). PET and wind speed (R2=0.56). The scattering pattern of PET and other thermal indices shows that all indexes have a significant correlation coefficient, between PET and UTCI (R2=0.99), between PET and SET (R2=0.98), and (R2=0.99) between PET and PMV.
Tari Angguk Sebagai Warisan Budaya Pada Masyarakat Jawa di Desa Dalu X B
Authors: Sihaloho Vilia Chintya , Heniwaty Yusnizar 
Published: June 2024

Tari Angguk sebagai Warisan Budaya Masyarakat Jawa di Dalu X B dikaji dengan menggunakan metode penelitian deskriptif dengan pendekatan kualitatif. Data dikumpulkan berdasarkan kondisi sebenarnya dilapangan dengan melakukan observasi, wawancara dan dokumentasi. Proses analisis digunakan teori pewarisan C.H Colley dan teori sejarah dari Roeslan Abdulgani serta teori bentuk menurut Sal Murgiyanto. Berdasarkan penelitian diketahui : (1) Sejarah persebaran Tari Angguk di Desa Dalu X B karena adanya transmigrasi pada masa Kolonialisme Belanda sehingga masyarakat Jawa tinggal dan menetap di Sumatera Utara dan melakukan aktifitas adat; (2) Pewarisan tari ini dilakukan dengan cara latihan dan melakukan berbagai upaya untuk mempertahankan tari ini. Tari ini masih terjaga karena adanya kerjasama antara pemilik sanggar, masyarakat dan pemerintah setempat. Hal ini tercermin dari penonton yang ramai saat pementasan Angguk pada acara masyarakat. (3) Bentuk Tari Angguk terdiri atas tigabelas judul lagu yang dilakukan dalam tiga tahapan. Instrumen yang digunakan sebagai music pengiring Angguk diantaranya, kendang, bedug, tamborin dan kerincingan. Tatarias yang digunakan make-up sehari-hari karena penari menggunakan kacamata, dan penari mengggunakan busana yang menyerupai seragam prajurit Belanda.Kata Kunci : Sejarah, Pewarisan, Pementasan Tari Angguk
Tari Hadra Pada Masyarakat Tanjung Morawa Kajian Tekstual dan Kontekstual
Authors: Ersuci Adinda Sandra , Nurwani Nurwani 
Published: June 2024

Penelitian ini bertujuan untuk mendeskripsikan Tekstual dan Kontekstual Tari Hadrah pada masyarakat Desa Dalu X B Tanjung Morawa. Metode yang digunakan adalah metode deskriptif dengan pendekatan kualitatif. Adapun pengumpulan data dilakukan dengan cara observasi, wawancara dan dokumentasi. Sampel penelitian adalah narasumber dan pemilik sanggar. Berdasarkan penelitian diketahui bahwa; Tari Hadrah yang berartikan hadir, tarian ini diiringi oleh musik melayu serta Shalawat dengan syair berisikan pujian-pujian kepada Allah SWT. Tari ini mampu bertahan dalam lingkungan masyarat Dalu X B karena masyarakat dan pemilik sanggar saling bekerjasama dengan menampilkan tari ini dalam acara seperti, khitanan,dan acara-acara Islami lainnya. Kata Kunci : Tari Hadrah, Tekstual, Kontekstual.
Sumpah Suci Anggun Nan Tongga : Indang Piaman Pada Penciptaan Teater Musikal
Authors: Ilahi Putra Ridho , Yusril Yusril , Soeryana Dharminta 
Published: June 2024

Sumpah Suci Anggun Nan Tongga adalah pertunjukan teater yang menggunakan pendekatan bentuk teater musikal dan memanfaatkan pola Indang Piama. Rumusan masalah dari proses penciptaan teater ini adalah bagaimana mewujudkan pertunjukan teater musikal Sumpah Suci Anggun Nan Tongga dengan pola indang piaman. Tujuan dari penciptaan karya ini terbagi menjadi dua, yaitu praktis dan akademis. Secara praktis karya ini bertujuan untuk menawarkan dan mengenalkan bentuk teater musikal kepada masyarakat. Secara akademis karya ini bertujuan untuk menawarkan konsep dan metode untuk menciptakan pertunjukan teater musikal berbasis seni tradisi. Metode penciptaan yang digunakan terdiri dari dua metode, yaitu metode penelitian dan metode penyutradaraan. Metode penelitian yang digunakan adalah observasi dan wawancara, sedangkan metode penyutradaraan yang digunakan adalah menentukan cerita, penyeleksian pemeran, pelatihan akting, komposisi musik, koreografi tari, latihan gabungan. Hasil yang dicapai dari proses penciptaan karya teater ini adalah pertunjukan teater musikal yang menitikberatkan pada kekuatan akting dan nyanyian. Kata Kunci: Anggun Nan Tongga, Indang Piaman, Teater Musikal