bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cisplatin based chemotherapy in patients with advanced differentiated thyroid carcinoma refractory to I131 treatment
Authors: Hussein Osama , Karen Drumea , Zidan Jamal 
Published: January 2014

Abstract
Purpose: The purpose of the study was to evaluate the activity and toxicity of cisplatin based chemotherapy in patients with advanced differentiated thyroid cancer refractory to radioactive iodine (I131). Patients and Methods: We retrospectively reviewed the records of 20 patients with advanced thyroid cancer treated with cyclophosphamide 500 mg/m 2 on day 1, doxorubicin 50 mg/m 2 day 1 and cisplatin 50 mg/m 2 day 1 of a 21 days cycle community-acquired pneumonia (CAP) or the same regimens without cyclophosphamide adriamycin and Platinum (AP). Results: Median age of patients was 65 years (range 54-80). The majority of patients had lung metastases (60%). 4 (20%) patients achieved a partial response. Stable disease was achieved in 6 (30%) patients. Overall clinical response was 50%. Mean follow-up time was 8 months (range 4-17). Mean progression free survival was 6 months (range 3-12). Mean overall survival was 9 months (range 4-17). Patients with partial remission had a mean time to disease progression of 9 months. 4 (20%) patients had Grade 3 or 4 neutropenia. One patient had febrile neutropenia. Mild neuropathy was recorded in 5 (25%) of patients. There were no treatment related deaths. Conclusion: The combination of CAP is active in the treatment of advanced thyroid cancer with tolerable toxicity. This regimen may still be used in patients who could not be treated with targeted therapy or combined with antiangiogenic drugs in future studies.
Comparison of the efficacy and safety of Rituximab (Mabthera™) and its biosimilar (Reditux™) in diffuse large B-cell lymphoma patients treated with chemo-immunotherapy: A retrospective analysis
Authors: Roy Partha Sarathi , John Shiji , Karankal Sadashiv , Kannan Sadhana , Pawaskar Preeti , Gawande Jayanta , Bagal Bhausaheb , Khattry Navin , Sengar Manju , Menon Hari , Gujral Sumeet , Nair Reena 
Published: January 2014

Abstract
Background: Rituximab (Mabthera™) have been in use in India since 2000. A biosimilar molecule of rituximab (Reditux™) was approved in India in 2007. This retrospective audit was done to compare the efficacy and safety of Mabthera™ with Reditux™. Materials and Methods: We reviewed the charts of 223 adult diffuse large B-cell lymphoma patients who had received cyclophosphamide, doxorubicin, vincristine and prednisolone with rituximab chemotherapy. Tumor recurrence, survival and toxicities experienced during chemotherapy were obtained from the patient charts. The survival analysis was restricted to patients who received at least 4 cycles of the same brand. Results: Of the 223 patients evaluated, 101 received Mabthera™, 72 received Reditux™. There were no differences in the infusional reaction rates, grades 3 and 4 neutropenia and oral mucositis between the two brands. Complete-remission (CR) rates were similar with Mabthera™ and Reditux™ (75% and 82%, respectively; P = 0.294). The progression free survival (PFS) rate at 5 years were 72% in Mabthera™ and 81% in Reditux™ (P = 0.382). The overall survival (OS) at 5 years were comparable in the two groups (66% in Mabthera™ and 76% in Reditux™; P = 0.264). Conclusion: We observed no significant differences in the toxicity, tumor response rates, PFS and OS between the two available brands of rituximab.
Histopathological pattern of lymphomas and clinical presentation and outcomes of diffuse large B cell lymphoma: A multicenter registry based study from India
Authors: Nimmagadda Ramesh B.V. , Digumarti Raghunadharao , Nair Reena , Bhurani Dinesh , Raina Vinod , Aggarwal Shyam , Patil Shekhar , Gogoi Pabitra , Sundaram Subramanian , Goswami Chanchal , Apte Shashikant , Chakravarthy Srinivas , Pathak Anand 
Published: January 2014

Abstract
Context: The distribution of various subtypes of lymphomas in India is different from other parts of the world. There is scarce multicentric data on the pattern and outcomes of lymphomas in India. Aims: The aim of this study is to evaluate the histopathological and the clinical pattern and treatment outcomes of lymphomas in India based on the retrospective data collected from a multicenter registry. Materials and Methods: Retrospective data was collected at 13 public and private hospitals in India for patients diagnosed with lymphoma between January 2005 and December 2009. The data collection was performed in the setting of a multicenter lymphoma registry Survival analyses were performed using the Kaplan-Meier method and compared using the log-rank test. Results: Non-Hodgkin′s lymphoma (NHL) constituted 83.17% and Hodgkin′s lymphoma (HL) for 16.83% of the 1733 registered and analyzed cases. Diffuse large B cell lymphoma (DLBCL) was the most common NHL (55%) followed by follicular lymphoma (11%). CHOP was the most common chemotherapy regimen administered (84%) while rituximab was used in 42.7% of those with DLBCL. Survival analysis of treatment naïve DLBCL patients (n = 791) was performed. Of these, 29% were lost to follow-up, 20% with active disease. The median follow-up in surviving patients is 31 (range: 1-88) months. Median progression-free survival (PFS) and overall survival (OS) in DLBCL patients has not reached. There was no significant difference in median PFS (69 months vs. 61 months, P = 0.1341), but OS was significant not reached (NR) vs. NR, P = 0.0012) within international prognostic index high or intermediate subgroups. Rituximab use was associated with significantly prolonged PFS (NR vs. 82 months, P = 0.0123), but not OS (NR vs. NR, P = 0.2214). Cox regression analysis in treatment naïve DLBCL patients showed a performatnce status, stage and receipt of six or more cycles of chemotherapy to be significantly associated with OS and all of the preceding plus rituximab use significantly associated with PFS. Conclusions: Our analysis confirms previous reports of distribution of lymphoma subtypes in India and suggests that patients who are able to receive the full course of chemotherapy achieve a better outcome. This indicates the importance of ensuring compliance to treatment utilizing various measures including patient and family counseling. Prospective studies are required to confirm these findings.
Primary mediastinal seminoma; resistance and relapse: An aggressive entity
Authors: Nachankar Ankita , Krishnatry Rahul , Joshi Amit , Noronha Vanita , Agarwal Jai Prakash 
Published: January 2014

AbstractSeminoma is one of the most radio and chemo sensitive tumors. Aggressive variant of primary mediastinal seminoma (PMS) are rarely described in the literature. We here discuss an interesting case of young male (22 years) presenting with superior vena cava syndrome due to PMS that showed poor response to conventional platinum based chemotherapy and radiotherapy. Furthermore, with a short disease free interval (one year) relapsed at unusual sites of bone and soft-tissue deposits in check. This emphasizes the importance of identifying methods to pre-screen such aggressive variants for more effective treatment options.
Flagellate erythema induced by bleomycin toxicity
Authors: Appaji L , Reddy C Vasu , Aruna Kumari B S , Padma M 
Published: January 2014

AbstractBleomycin is a chemotherapeutic antibiotic used in various malignancies. Its toxicity is mainly lung and skin with marrow sparing effect. Here we would like to describe a characteristic skin reaction developed because of bleomycin in a case of intracranial germ cell tumor. Flagellate erythema which is a self-limiting toxic reaction can cause residual hyperpigmentation.
Challenges to the Control of Breast Cancer in a Small Developing Country
Authors: Mungrue Kameel , Ramdath Jeremy , Ali Siddiq , Cuffie Winsie-Ann , Dodough Nicholas , Gangar Misty , Mohammed Laura , Mungroo Vikash , Ramsahai Justin , Shah Mariyah 
Published: January 2014

Objective The aim of this study is to determine the clinicopathological features of breast cancer in two dedicated cancer treatment centers in north Trinidad. The histological types and stage at presentation were also investigated. Design and Methods A retrospective cohort design was used; data were collected from a review of medical records of patients meeting the entry criteria. Clinical and demographic data were extracted. Results A total of 640 patients were selected for the study and were available for the analysis. The annual cumulative incidence rate of breast cancer for the calendar years 2010 and 2011 in north Trinidad was 32.4 per 100,000 and 24.6 per 100,000 of the population. The age group between 51–60 years had the highest proportion of cases of breast cancer. There was a significant ethnic disparity in the occurrence of breast cancer, as it was more common in people of African origin than among South East Asians. Surgery and chemotherapy were the major interventions employed. Conclusion Breast cancer prevalence continues to be high in Trinidad; we provide evidence of the extent of and the degree of sophistication required to care for patients with breast cancer in a health care system in a small developing country.
OmicCircos: A Simple-to-Use R Package for the Circular Visualization of Multidimensional Omics Data
Authors: Hu Ying , Yan Chunhua , Hsu Chih-Hao , Chen Qing-Rong , Niu Kelvin , Komatsoulis George A. , Meerzaman Daoud 
Published: January 2014

Summary OmicCircos is an R software package used to generate high-quality circular plots for visualizing genomic variations, including mutation patterns, copy number variations (CNVs), expression patterns, and methylation patterns. Such variations can be displayed as scatterplot, line, or text-label figures. Relationships among genomic features in different chromosome positions can be represented in the forms of polygons or curves. Utilizing the statistical and graphic functions in an R/Bioconductor environment, OmicCircos performs statistical analyses and displays results using cluster, boxplot, histogram, and heatmap formats. In addition, OmicCircos offers a number of unique capabilities, including independent track drawing for easy modification and integration, zoom functions, link-polygons, and position-independent heatmaps supporting detailed visualization. Availability and Implementation OmicCircos is available through Bioconductor at http://www.bioconductor.org/packages/devel/bioc/html/OmicCircos.html . An extensive vignette in the package describes installation, data formatting, and workflow procedures. The software is open source under the Artistic—2.0 license.
On Semisimple Hopf Algebras of Dimension pqn
Authors: Dai Li , Dong Jingcheng 
Published: January 2014

AbstractLet p, q be prime numbers with p2 < q, n ∊ ℕ, and H a semisimple Hopf algebra of dimension pqn over an algebraically closed field of characteristic 0. This paper proves that H must possess one of the following two structures: (1) H is semisolvable; (2) H is a Radford biproduct R#kG, where kG is the group algebra of group G of order p and R is a semisimple Yetter–Drinfeld Hopf algebra in of dimension qn.
Let Our Voices Be Heard: Urban Minority Adolescents Share Their Perspectives regarding Substance Abuse and HIV/AIDS Prevention Messages
Authors: Reid Robert J. , Garcia-Reid Pauline , Forenza Brad , Eckert Caitlin , Carrier Melissa , Drag Stephanie 
Published: January 2014

Purpose. This study explored the substance abuse and human immunodeficiency virus prevention needs of urban minority adolescents. Design. Six 1-hour focus groups. Setting. Two high schools and two community-based organizations located in the city of Paterson, New Jersey. Participants. The sample included 41 African-American and Latino youth, ranging in ages from 13 to 18 years. Method. Data were collected through six focus group interviews. Each group discussion was audio-recorded and transcribed. Qualitative software was then used to facilitate the processes of thematic analysis, until emergent themes transcended the data. To bolster the rigor and confirmability of analysis, additional researchers coded stratified selections of transcript. Results. Study participants were able to identify the environmental threats and structural deficits impacting their city. Few of the youth were able to recognize substance abuse and HIV/AIDS prevention messages in their immediate surroundings. Additionally, most participants indicated that prevention messages must be delivered in authentic ways from relatable sources in order to resonate with their audience. Conclusion. Our findings emphasize the importance of infusing the adolescents' voices into the design and implementation of health promotion messages, which could serve to increase their receptivity and responsiveness, and the overall resonance of the interventions.
Performance Analysis of GPS/GLONASS Precise Point Positioning
Authors: Azab Mohamed , El-Rabbany Ahmed , Shoukry M. Nabil , Khalil Ramadan , Afifi Akram 
Published: January 2014

Precise Point Positioning (PPP) with Global Positioning Systems (GPS) has attracted the attention of many researchers over the past decade. Recently, the Russian global navigation satellite system (GLONASS) has been modernized and restored to near full constellation status, which has made it more attractive for positioning and navigation. Having two healthy systems, namely GPS and GLONASS provides a combination of both constellations, which in turn promises to improve the availability, positioning accuracy, and reliability of PPP solutions. This study investigates the effect of combining GPS and GLONASS dual-frequency measurements on the static PPP solution and its sensitivity to different processing strategies. Many data sets from five globally distributed International GNSS Service (IGS) tracking stations were processed using the Bernese GPS software package. The addition of GLONASS constellation improved the satellite visibility and geometry by more than 60%, and 40%, respectively, and improves the positioning convergence by up to 41%, 38%, and 19% in east, north, and up directions, respectively.
Cadherin-17 and SATB2 Are Sensitive and Specific Immunomarkers for Medullary Carcinoma of the Large Intestine
Authors: Lin Fan , Shi Jianhui , Zhu Shaobo , Chen Zongming , Li Aihua , Chen Taiying , Wang Hanlin L. , Liu Haiyan 
Published: January 2014

Context.—Distinction of medullary carcinoma of the large intestine from other cytokeratin (CK) 7−/CK20− carcinomas can be challenging when working on a tumor of unknown primary because the majority of medullary carcinomas are negative for CK7, CK20, and CDX2.Objective.—To investigate the expression of cadherin-17 and SATB-2 and other markers in medullary carcinomas of the large intestine and cadherin-17 and SATB2 in a large number of carcinomas and normal tissues from various organs to further test their diagnostic specificity.Design.—This study evaluated cadherin-17 and SATB2 expression in 18 medullary carcinoma cases and 1941 tumors and 358 normal tissues from various organs. Other immunomarkers, including MLH1, PMS2, MSH2, MSH6, CDX2, CK7, CK20, TFF3, MUC4, calretinin, p504S, villin, and synaptophysin, were also tested on the 18 medullary carcinoma cases.Results.—The results demonstrated (1) loss of MLH1 and PMS2 in more than 80% of medullary carcinomas; (2) expression of cadherin-17 and SATB2 in 89% of medullary carcinomas; (3) focal expression of TFF3, MUC4, calretinin, CDX2, CK20, and synaptophysin in 72%, 72%, 67%, 67%, 28%, and 17% of 18 medullary carcinoma cases, respectively; and (4) expression of SATB2 and cadherin-17 in 97% and 98% of the colorectal adenocarcinomas, respectively, whereas their expression was seen in 3.6% and 3.3% of nongastrointestinal tumors, respectively.Conclusion.—We concluded that SATB2 and cadherin-17 were highly sensitive and specific markers for colorectal carcinomas and propose including MLH1, cadherin-17, and SATB2 in a routine immunostaining panel when working on a tumor of unknown primary, especially in an elderly patient with a CK7−/CK20− carcinoma.
Vous avez dit « continuité des services » ? Les professionnels de l’employabilité face aux catégories de l’immigration et de la jeunesse
Authors: Lendaro Annalisa , Goyette Martin 
Published: January 2014

Au Québec, l’ensemble des acteurs concernés par la conception, le financement et la mise en oeuvre des politiques de la jeunesse semblent s’accorder sur une chose : l’objectif à viser est la « continuité des services », c’est-à-dire la complémentarité des programmes, qui permettrait au jeune, en fonction de l’évolution de ses besoins, d’entrer dans l’un de ces derniers sans se retrouver dans un « vide de droits ». Dans un contexte de pénurie de ressources financières et de compétition accrue entre les organismes d’accompagnement, l’article se propose de porter un éclairage sur les enjeux du processus de ciblage des populations à travers le cas des jeunes immigrants. Nous présenterons dans un premier temps le contexte institutionnel, pour ensuite mettre en exergue le rôle des professionnels de l’employabilité, dont les pratiques sont tiraillées entre les objectifs à atteindre et les cas spécifiques des usagers.
Les recompositions culturelles des « jeunes de cité » à l’épreuve des déterminismes sociaux et des effets du chômage, de la discrimination et de la ségrégation urbaine
Authors: Marlière Éric 
Published: January 2014

Enfants d’ouvriers et d’immigrés pour la plupart, les jeunes dits « de cité » sont les déshérités du monde ouvrier et de son système social. Depuis plus de deux générations, ces jeunes ont développé des modes de vie qui leur sont, en partie, spécifiques : entre « culture de rue », pratiques religieuses musulmanes et, pour contrecarrer le chômage et la précarité, entrée dans une petite délinquance de masse. Bien que les trajectoires sociales soient diverses chez les « jeunes de cité », ces derniers sont confrontés à des difficultés économiques et sociales auxquelles s’ajoutent les effets des discriminations et de la ségrégation urbaine qui en font irrémédiablement des « boucs émissaires ». En réponse à ces nombreux obstacles émerge chez ces jeunes un sentiment d’injustice unanimement partagé.
Des pratiques culturelles contre l’échec et le décrochage scolaires. Sociologie d’un détour
Authors: Bonnéry Stéphane , Renard Fanny 
Published: January 2014

L’article porte sur des dispositifs mis en place dans le cadre de partenariats entre l’Éducation nationale, des collectivités territoriales et des associations d’éducation populaire au gré de politiques de « lutte contre le décrochage scolaire » ou de « programmes de réussite éducative ». Répondant aux diagnostics officiels des difficultés scolaires, ces dispositifs proposent des activités artistiques aux élèves de primaire ou de collège. Nous montrons les difficultés que ces dispositifs rencontrent ainsi que leur caractère paradoxal au vu de la persistance des inégalités culturelles. Qu’apportent des activités pédagogiques de détour qui masquent les enjeux scolaires qui les sous-tendent ?
Défis et conditions de l’accompagnement de la sortie de la rue
Authors: Colombo Annamaria 
Published: January 2014

Comment comprendre que des programmes d’intervention aident certains jeunes à sortir de la marginalité, mais qu’ils ne représentent pas une aide significative pour d’autres ? Comment expliquer que certains jeunes soient demandeurs d’une aide, alors que d’autres, apparemment dans la même situation, semblent fuir toute relation d’aide ? À partir d’une recherche menée auprès de jeunes sortis de la rue, l’article montre que l’accompagnement de la sortie de la rue ne peut faire l’impasse sur le sens que les jeunes accordent à la relation d’aide, en fonction des attentes de reconnaissance qu’ils ont. Il propose de lire les enjeux qui se jouent aussi bien dans la demande que dans la non-demande d’aide sous leurs différentes formes, à la lumière des trajectoires spécifiques des jeunes.
The vulnerability of men to virologic failure during antiretroviral therapy in a public routine clinic in Burkina Faso
Authors: Penot Pauline , Héma Arsène , Bado Guillaume , Kaboré Firmin , Soré Ibrahim , Sombié Diamasso , Traoré Jean‐Richard , Guiard‐Schmid Jean‐Baptiste , Fontanet Arnaud , Slama Laurence , Sawadogo Adrien Bruno , Laurent Christian 
Published: January 2014

IntroductionGender differences in antiretroviral therapy (ART) outcomes are critical in sub‐Saharan Africa. We assessed the association between gender and virologic failure among adult patients treated in a public routine clinic (one of the largest in West Africa) in Burkina Faso.MethodsWe performed a case‐control study between July and October 2012 among patients who had received ART at the Bobo Dioulasso Day Care Unit. Patients were eligible if they were 15 years or older, positive for HIV‐1 or HIV‐1+2, and on first‐line ART for at least six months. Cases were all patients with two consecutive HIV loads >1000 copies/mL (Biocentric Generic or Abbott Real Time assays), or one HIV load >1000 copies/mL associated with immunologic or clinical failure criteria. Controls were all patients who only had HIV loads <300 copies/mL. The association between gender and virologic failure was assessed using a multivariate logistic regression, adjusted on age, level of education, baseline CD4+ T cell count, first and current antiretroviral regimens and time on ART.ResultsOf 2303 patients (74.2% women; median age: 40 years; median time on ART: 34 months), 172 had virologic failure and 2131 had virologic success. Among the former, 130 (75.6%) had confirmed virologic failure, 38 (22.1%) had viro‐immunologic failure, and four (2.3%) had viro‐clinical failure. The proportion of men was significantly higher among the cases than among the controls (37.2% vs. 24.9%; p<0.001). Compared to controls, cases were also younger, more immunodeficient at ART initiation, less likely to receive a protease inhibitor‐based antiretroviral regimen and had spent a longer period of time on ART. After adjustment, male gender remained strongly associated with virologic failure (odds ratio 2.52, 95% CI: 1.77–3.60; p<0.001).ConclusionsMen on ART appeared more vulnerable to virologic failure than women. Additional studies are needed to confirm the poorer prognosis of men in this setting and to determine the causes for their vulnerability in order to optimize HIV care. From now on, efforts should be made to support the adherence of men to ART in the African setting.
Crustal and uppermost mantle structure beneath western Tibet using seismic traveltime tomography
Authors: Razi Ayda Shokoohi , Levin Vadim , Roecker Steven W. , Huang Guo‐chin Dino 
Published: January 2014

AbstractWe study the elastic wave speed structure of the crust and the uppermost mantle in western Tibet using P wave and S wave arrival times from regional earthquakes recorded by a temporary seismic network. We relocate the earthquakes, and subsequently invert travel time residuals for 3‐D distributions of wave speed. Resolution tests with a variety of input structures are used to verify the reliability of our results. The crust beneath western Tibet has low P wave speed (5.9–6.3 km/s) throughout its nearly 80 km thickness, with lower values in this range concentrated within the Lhasa block. Beneath the Himalaya wave speeds are higher. Southern and western limits of the slow material beneath the Tibetan Plateau correlate with the Karakoram fault, and dip beneath the plateau at ∼40° angle. We find no evidence of a subhorizontal low velocity zone in the crust. In the uppermost mantle, we find a long and narrow region of fast (up to 8.4 km/s) P wave speed extending from the Karakoram fault in NE direction, and crossing the Bangong‐Nujiang suture. In a north‐south cross section, the distribution of relatively fast P wave speed suggests a ramp‐flat geometry consistent with India underthrusting the Tibetan Plateau at least as far as 32.5°N. A plausible interpretation of the upper mantle fast feature is the formation of eclogite from the mafic lower‐crustal material of India after it is underthrust beneath Tibet. Notably, in western Tibet this process only takes place in a narrow region.