bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluating the readability of marketing research textbooks: an international comparison
Authors: Berndt Adele , P. Wayland Jane 
Published: April 2014

Purpose– Locally authored textbooks are used at tertiary South African institutions to assist in marketing research studies. The purpose of this paper is to investigate the readability of locally authored marketing research textbooks in South Africa and compare them with international (USA) texts.Design/methodology/approach– South African marketing research textbooks (authored locally) used at South African institutions were identified. Electronic versions of the textbooks were used and analysed using accepted readability formulae. The same procedure was used with texts produced in the USA and the findings of each were compared.Findings– The South Africa texts scored higher on the Flesch Reading Ease score than US texts, which links to the target audience of these books (undergraduate students), while also being cognisant of the reading skills of the target audience but their score still describes them as “difficult”.Research limitations/implications– The original formulae and theory tend to be dated, though there are recent studies into readability in other areas of business studies. There are also those that question the applicability of readability formulae in the tertiary environment.Practical implications– Instructors need to ensure that material is at a suitable reading level to maximise the student's learning. For publishers and authors, this means that the examples and illustrations used need to be linked to the context in which the student lives and functions, and not just focus on the English used in the text.Originality/value– While studies have been conducted into the readability of US textbooks, there is little published research into the readability of regional marketing research textbooks in other contexts to facilitate comparison.
Students achieving intercultural competence through group work: realised or idealised?
Authors: Burdett Jane 
Published: April 2014

Purpose– The purpose of this study was to explore local and international business students' perceptions of their intercultural group work experience as a mechanism for developing intercultural competence and group work skills.Design/methodology/approach– Using qualitative interviews, the group work experiences of 11 final-year undergraduate local and international students in a business program in a large Australian university were analysed.Findings– The findings suggest that international and local students working together on group assignments create social and academic situations that result in “at best” limited positive intercultural learning and relationships. Differences in expectations, motivations, language fluency, trust and relationship issues were evident when students collaborated on group assignments. Thus, it appears that group assignments are potentially flawed mechanisms for delivering the goals of intercultural competence and group work skills in business students.Practical implications– Although this exploratory study is limited in scope, the research has implications for pedagogical strategies, in particular, the use and design of group assignments and the preparation of students for working on group tasks in intercultural groups. It also has implications for developing effective learning mechanisms that lead to improved student intercultural competence, greater socio-cultural engagement and the academic success of international and local business students, as well as positive learning experiences for all.Originality/value– The findings of this study are likely to be a useful resource for university staff considering the use of group work assignments for the development of intercultural understanding and competence and collaborative skills.
Candidates' integration of individual psychological assessment feedback
Authors: Boudrias Jean-Sébastien , Bernaud Jean-Luc , Plunier Patrick 
Published: April 2014

Purpose
– The purpose of this paper is to empirically verify a theoretical model of candidates' feedback integration in the context of individual psychological assessment (IPA).

Design/methodology/approach
– Structural equation modeling analyses were conducted in a two-wave longitudinal study. A total of 97 candidates completed questionnaires immediately after their feedback session as well as three months later.

Findings
– Results indicate that candidates' motivational intention to act on IPA feedback is a pivotal variable linking feedback perceptions and post-feedback behaviors. Source credibility, assessment face validity, as well as perception that the feedback helped increase candidate's awareness were related to motivational intention. Conversely, feedback acceptance was not related to candidates' motivation to act on feedback and post-feedback behaviors.

Research limitations/implications
– Because the authors relied on self-report questionnaires, future studies would benefit from including externally assessed behavioral outcomes. Future research efforts should continue distinguishing candidates' acceptance and awareness based on their distinctive contributions in the feedback integration process.

Practical implications
– The results indicate that motivation created during the feedback session is a stronger predictor of day-to-day behavioral changes than it is of involvement in specific developmental activities.

Originality/value
– This research fills a gap in IPA literature by highlighting some IPA benefits and the processes involved in increasing feedback value for the participant.
The identity-based explanation of affective commitment
Authors: W. Lam Long , Liu Yan 
Published: April 2014

Purpose– Drawing on social identity and self-categorization theories and building on Meyer and Herscovitch's (2001) work on affective commitment, this study aimed to examine the relationship between organizational identification and affective commitment, and the relationships between these two variables and employees' attitude and behavior.Design/methodology/approach– Data were collected on-site from 158 automobile dealership employees in central China. Regression analysis and hierarchical linear modeling were used to analyze the survey data.Findings– Organizational identification was positively related to affective commitment. Affective commitment was negatively related to turnover intention and positively related to job performance. Affective commitment mediated the relationship between organizational identification and turnover intention, but did not mediate the relationship between organizational identification and job performance.Research limitations/implications– This study contributes to the literature by integrating organizational identification and affective commitment, the two distinct types of employees' organizational attachment. However, results should be cautioned with the limitations of the study.Practical implications– Managers can use employees' organizational identification to foster affective commitment since it leads to a variety of positive work attitudes and behavior.Social implications– Society as a whole may benefit by having more loyal and committed workforce in organisations.Originality/value– This study develops a model that aligns employee commitment and identification. Doing so answers the call for more efforts to integrate the two forms of organizational attachment in order to make more progress in this line of research.
Both biotic and abiotic factors influence floral longevity in three species of Epidendrum (Orchidaceae)
Authors: Vega Yesenia , Marques Isabel 
Published: April 2014

AbstractExtended flower longevity has been widely defended to occur as a consequence of low pollination activity. To test this hypothesis in Neotropical rainforests, we selected three species of Epidendrum that flower during rainy conditions and commonly exhibit low levels of insect visits. Experimental studies carried out in 15 populations distributed along a wide spatial gradient detected the presence of pollinator limitation in all populations. Pollinia removal without pollen deposition increased longevity, and thus extended longevity could apparently be considered as an ecological advantage for these orchids. Nevertheless, flower longevity was severely shortened by abiotic factors like precipitation and humidity. Comparison with other tropical orchids showed that flower longevity was higher even in species that flower during periods of more pollinator activity than the ones studied here, which is contrary to the hypothesis that pollinators are the only driving force for long‐lived flowers in Epidendrum. Thus, although long floral longevities are apparently favorable for the reproductive success of these species, the high maintenance costs experienced during rainy conditions are also an important factor constraining the selection of long‐lived flowers in Epidendrum.
The Stalking of Lawyers: A Survey Amongst Professionals in Milan
Authors: Merzagora Betsos Isabella , Marchesi Matteo 
Published: April 2014

AbstractThis is the first study focused on the stalking of lawyers. The authors hypothesized that these professionals are at risk of being stalked by their clients and that this stalking is ascribable to RECON type I.B. A random sample of lawyers was survived. 37.3% of 166 respondents revealed to have been stalked: not only by clients, but also by adversaries and colleagues. Data seem to confirm that the stalking of lawyers mainly belongs to RECON type I.B. Female lawyers were at greater risk than male lawyers. In family law cases, the professionals tended to be stalked by the former husbands of the lawyers' clients (p < 0.01). Several female lawyers—but no male lawyers—were threatened with harm to their family members (p < 0.05). Most of the stalking victims described psychological effects of being stalked. Who suffered physical aggression or repercussions on work was more likely to lodge a complaint (p < 0.01).
Acute Benztropine Intoxication and Fatality
Authors: McIntyre Iain M. , Mallett Phyllis , Burton Christopher G. , Morhaime Jacquelyn 
Published: April 2014

AbstractA woman was found unresponsive with an empty bottle of Cogentin® prescribed to another. Admitted to an area hospital, her condition steadily declined until death 29 h after admission. Following toxicological screening on hospital (admission) whole blood, the only significant compound detected was benztropine. Benztropine was confirmed at 0.28 mg/L – the highest antemortem blood concentration recorded in a case of toxicity or fatality uniquely associated with benztropine. A second serum antemortem specimen showed a benztropine concentration of 0.19 mg/L. Despite over 24 h in the hospital, benztropine was also found in the postmortem specimens collected at autopsy. Peripheral blood, central blood, liver, and gastric concentrations were 0.47 mg/L, 0.36 mg/L, 9.6 mg/kg, and 44 mg, respectively. These results indicate that benztropine exhibited a potential difference between whole‐blood and serum (plasma) concentrations. Additionally, in consideration of literature data, benztropine was found indicative of a compound prone to at least some postmortem redistribution.
Challenges in the sequencing of therapies for the management of metastatic castration‐resistant prostate cancer
Authors: Parente Phillip , Parnis Francis , Gurney Howard 
Published: April 2014

AbstractPrior to 2010, docetaxel was the standard option for chemotherapy in men with metastatic castration‐resistant prostate cancer (mCRPC). Today, the picture is vastly different: several additional therapies have each demonstrated a survival benefit such that we now have chemotherapy (cabazitaxel), androgen suppressive agents (abiraterone acetate and enzalutamide), a cellular vaccine (sipuleucel‐T) and radium‐233 (for symptomatic bone metastases). With several other agents in the pipeline for late‐stage disease, the future looks promising for mCRPC. As the available data are not able to inform as to the optimum sequencing of therapy, this remains a challenge. This paper draws on insights from published and ongoing clinical studies to provide a practical patient‐focused approach to maximize the benefits of the current therapeutic armamentarium. Preliminary sequencing suggestions are made based on clinical trial criteria. But until more data become available, clinical gestalt, experience, cost and individual patient preferences will continue to drive choices.
The Roles of Economic Freedom and Regulatory Quality in Creating a Favorable Environment for Investment in EnergyR&D, Infrastructure, and Capacity
Authors: Cebula Richard J. , Mixon Franklin G. 
Published: April 2014

AbstractSustainable investment in energy requires a favorable economic and regulatory environment. A random effects model (PLSestimations), using a four‐year panel, reveals the growth rate in real per capitaGDPforOECDnations as an increasing function of both economic freedom and regulatory quality. These results underscore the critical roles that economic freedom and regulatory quality play, directly and indirectly, in creating an environment conducive to sustainable investment in energyR&Dand infrastructure.
Public Choice and the EPA, 20 Years Later: An Exploratory Study
Authors: Cebula Richard J. , Mixon Franklin G. , Upadhyaya Kamal P. 
Published: April 2014

AbstractNearly 20 years ago, Mixon (1995) found that urban warming is positively related to the probability of an EPA citation for a violation of carbon emissions standards, whereas lobbying effort reduces the probability of such a citation. This study revisits the Mixon (1995) framework by using data on ozone violations. The results indicate that EPA citations for ozone violations are not significantly related to lobbying effort.
EAACI Food Allergy and Anaphylaxis Guidelines. Primary prevention of food allergy
Authors: Muraro A. , Halken S. , Arshad S. H. , Beyer K. , Dubois A. E. J. , Du Toit G. , Eigenmann P. A. , Grimshaw K. E. C. , Hoest A. , Lack G. , O'Mahony L. , Papadopoulos N. G. , Panesar S. , Prescott S. , Roberts G. , de Silva D. , Venter C. , Verhasselt V. , Akdis A. C. , Sheikh A. ,   EAACI Food Allergy and Anaphylaxis Guidelines Group
Published: April 2014

AbstractFood allergy can have significant effects on morbidity and quality of life and can be costly in terms of medical visits and treatments. There is therefore considerable interest in generating efficient approaches that may reduce the risk of developing food allergy. This guideline has been prepared by the European Academy of Allergy and Clinical Immunology's (EAACI) Taskforce on Prevention and is part of the EAACI Guidelines for Food Allergy and Anaphylaxis. It aims to provide evidence‐based recommendations for primary prevention of food allergy. A wide range of antenatal, perinatal, neonatal, and childhood strategies were identified and their effectiveness assessed and synthesized in a systematic review.Based on this evidence, families can be provided with evidence‐based advice about preventing food allergy, particularly for infants at high risk for development of allergic disease. The advice for all mothers includes a normal diet without restrictions during pregnancy and lactation. For all infants, exclusive breastfeeding is recommended for at least first 4–6 months of life. If breastfeeding is insufficient or not possible, infants at high‐risk can be recommended a hypoallergenic formula with a documented preventive effect for the first 4 months. There is no need to avoid introducing complementary foods beyond 4 months, and currently, the evidence does not justify recommendations about either withholding or encouraging exposure to potentially allergenic foods after 4 months once weaning has commenced, irrespective of atopic heredity. There is no evidence to support the use of prebiotics or probiotics for food allergy prevention.
Exhaled carbon dioxide can be used to guide respiratory support in the delivery room
Authors: van Os Sylvia , Cheung Po‐Yin , Pichler Gerhard , Aziz Khalid , O'Reilly Megan , Schmölzer Georg M. 
Published: April 2014

AbstractRespiratory support in the delivery room remains challenging. Assessing chest rise is imprecise, and mask leak and airway obstruction are common problems. We describe recordings of respiratory signals during delivery room resuscitations and discuss guidance on positive‐pressure ventilation using respiratory parameters and exhaled carbon dioxide (ECO2) during neonatal resuscitations.ConclusionObserving tidal volume and ECO2 waveforms adds objectivity to clinical assessments. ECO2 could help assess lung aeration and improve lung recruitment immediately after birth.
ALK gene aberrations and the JUN/JUNB/PDGFR axis in metastatic NSCLC
Authors: Berghoff Anna Sophie , Birner Peter , Streubel Berthold , Kenner Lukas , Preusser Matthias 
Published: April 2014

Anaplastic lymphoma kinase (ALK) gene aberrations are found in several tumor types including anaplastic large cell lymphoma (ALCL) and non‐small cell lung cancer (NSCLC). Crizotinib, an inhibitor of ALK‐fusion proteins, has shown clinical activity, but resistance mechanisms limit long‐lasting disease control. It has been shown that ALK‐NPM fusion upregulates platelet‐derived growth factor receptor beta (PDGFRB) via JUN and transcription factor Jun B (JUNB) in ALCL. PDGFRB inhibition has been identified as therapy option for ALK‐positive ALCL. Here, we investigated the ALK/JUN/JUNB/transcription factor Jun C (JUNC)/PDGFR axis in metastatic NSCLC with regard to ALK aberrations. We performed immunohistochemical analysis of platelet‐derived growth factor receptor alpha (PDGFRA), PDGFRB, JUNB and JUNC expression in formalin‐fixed, paraffin‐embedded specimens of 15 NSCLC brain metastases (5 ALK translocations, 3 of them involving EML4, 5 ALK amplifications, 5 without ALK aberrations). We did not find a statistically significant difference in expression of PDGFRA, PDGFRB, JUNB or JUNC in tumor samples with normal ALK status, ALK amplification or ALK translocations (Kruskal–Wallis test p > 0.05). Interestingly, PDGFRB was not expressed in tumor cells (but in vascular and stromal cells) in any of our cases. Our data argue against PDGFRB activation in association with ALK gene aberrations in metastatic NSCLC and thus seem to imply differential pathobiological roles of ALK alterations in lung cancer and lymphoma, possibly depending on different fusion partner genes. These results may be relevant for targeted therapies, as they indicate that inhibition of PDGFRB in ALK translocated NSCLC seems to be no therapeutic opportunity.
Population pharmacokinetic modelling to assess the impact of CYP2D6 and CYP3A metabolic phenotypes on the pharmacokinetics of tamoxifen and endoxifen
Authors: ter Heine Rob , Binkhorst Lisette , de Graan Anne Joy M. , de Bruijn Peter , Beijnen Jos H. , Mathijssen Ron H. J. , Huitema Alwin D. R. 
Published: April 2014

AimsTamoxifen is considered a pro‐drug of its active metabolite endoxifen. The major metabolic enzymes involved in endoxifen formation are CYP2D6 and CYP3A. There is considerable evidence that variability in activity of these enzymes influences endoxifen exposure and thereby may influence the clinical outcome of tamoxifen treatment. We aimed to quantify the impact of metabolic phenotype on the pharmacokinetics of tamoxifen and endoxifen.MethodsWe assessed the CYP2D6 and CYP3A metabolic phenotypes in 40 breast cancer patients on tamoxifen treatment with a single dose of dextromethorphan as a dual phenotypic probe for CYP2D6 and CYP3A. The pharmacokinetics of dextromethorphan, tamoxifen and their relevant metabolites were analyzed using non‐linear mixed effects modelling.ResultsPopulation pharmacokinetic models were developed for dextromethorphan, tamoxifen and their metabolites. In the final model for tamoxifen, the dextromethorphan derived metabolic phenotypes for CYP2D6 as well as CYP3A significantly (P < 0.0001) explained 54% of the observed variability in endoxifen formation (inter‐individual variability reduced from 55% to 25%).ConclusionsWe have shown that not only CYP2D6, but also CYP3A enzyme activity influences the tamoxifen to endoxifen conversion in breast cancer patients. Our developed model may be used to assess separately the impact of CYP2D6 and CYP3A mediated drug–drug interactions with tamoxifen without the necessity of administering this anti‐oestrogenic drug and to support Bayesian guided therapeutic drug monitoring of tamoxifen in routine clinical practice.
Prediction of paraquat exposure and toxicity in clinically ill poisoned patients: a model based approach
Authors: Wunnapuk Klintean , Mohammed Fahim , Gawarammana Indika , Liu Xin , Verbeeck Roger K. , Buckley Nicholas A. , Roberts Michael S. , Musuamba Flora T. 
Published: April 2014

AimsParaquat poisoning is a medical problem in many parts of Asia and the Pacific. The mortality rate is extremely high as there is no effective treatment. We analyzed data collected during an ongoing cohort study on self‐poisoning and from a randomized controlled trial assessing the efficacy of immunosuppressive therapy in hospitalized paraquat‐intoxicated patients. The aim of this analysis was to characterize the toxicokinetics and toxicodynamics of paraquat in this population.MethodsA non‐linear mixed effects approach was used to perform a toxicokinetic/toxicodynamic population analysis in a cohort of 78 patients.ResultsThe paraquat plasma concentrations were best fitted by a two compartment toxicokinetic structural model with first order absorption and first order elimination. Changes in renal function were used for the assessment of paraquat toxicodynamics. The estimates of toxicokinetic parameters for the apparent clearance, the apparent volume of distribution and elimination half‐life were 1.17 l h−1, 2.4 l kg−1 and 87 h, respectively. Renal function, namely creatinine clearance, was the most significant covariate to explain between patient variability in paraquat clearance.This model suggested that a reduction in paraquat clearance occurred within 24 to 48 h after poison ingestion, and afterwards the clearance was constant over time. The model estimated that a paraquat concentration of 429 μg l−1 caused 50% of maximum renal toxicity. The immunosuppressive therapy tested during this study was associated with only 8% improvement of renal function.ConclusionThe developed models may be useful as prognostic tools to predict patient outcome based on patient characteristics on admission and to assess drug effectiveness during antidote drug development.
Relative Contributions of the Logging, Fiber, Oil Palm, and Mining Industries to Forest Loss in Indonesia
Authors: Abood Sinan A. , Lee Janice Ser Huay , Burivalova Zuzana , Garcia‐Ulloa John , Koh Lian Pin 
Published: April 2014

AbstractIndonesia contributes significantly to deforestation in Southeast Asia. However, much uncertainty remains over the relative contributions of various forest‐exploiting sectors to forest losses in the country. Here, we compare the magnitudes of forest and carbon loss, and forest and carbon stocks remaining within oil palm plantation, logging, fiber plantation (pulp and paper), and coal mining concessions in Indonesia. Forest loss in all industrial concessions, including logging concessions, relate to the conversion of forest to nonforest land cover. We found that the four industries accounted for ∼44.7% (∼6.6 Mha) of forest loss in Kalimantan, Sumatra, Papua, Sulawesi, and Moluccas between 2000 and 2010. Fiber plantation and logging concessions accounted for the largest forest loss (∼1.9 Mha and ∼1.8 Mha, respectively). Although the oil palm industry is often highlighted as a major driver of deforestation, it was ranked third in terms of deforestation (∼1 Mha), and second in terms of carbon dioxide emissions (∼1,300–2,350 Mt CO2). Crucially, ∼34.6% (∼26.8 Mha) of Indonesia's remaining forests is located within industrial concessions, the majority of which is found within logging concessions (∼18.8 Mha). Hence, future development plans within Indonesia's industrial sectors weigh heavily on the fate of Southeast Asia's remaining forests and carbon stocks.