bluuebunny/crossref_metadata_2025_split huggingface dataset:
Histone Deacetylation Critically Determines T Cell Subset Radiosensitivity
Authors: Pugh Jason L. , Sukhina Alona S. , Seed Thomas M. , Manley Nancy R. , Sempowski Gregory D. , van den Brink Marcel R. M. , Smithey Megan J. , Nikolich-Žugich Janko 
Published: July 2014

Abstract
Lymphocytes are sensitive to ionizing radiation and naive lymphocytes are more radiosensitive than their memory counterparts. Less is known about radiosensitivity of memory cell subsets. We examined the radiosensitivity of naive (TN), effector memory (TEM), and central memory (TCM) T cell subsets in C57BL/6 mice and found TEM to be more resistant to radiation-induced apoptosis than either TN or TCM. Surprisingly, we found no correlation between the extent of radiation-induced apoptosis in T cell subsets and 1) levels of pro- and antiapoptotic Bcl-2 family members or 2) the H2AX content and maximal γH2AX fold change. Rather, TEM cell survival correlated with higher levels of immediate γH2AX marking, immediate break binding and genome-wide open chromatin structure. T cells were able to mark DNA damage seemingly instantly (30 s), even if kept on ice. Relaxing chromatin with the histone deacetylase inhibitor valproic acid following radiation or etoposide treatment improved the survival of TCM and TN cells up to levels seen in the resistant TEM cells but did not improve survival from caspase-mediated apoptosis. We conclude that an open genome-wide chromatin state is the key determinant of efficient immediate repair of DNA damage in T cells, explaining the observed T cell subset radiosensitivity differences.
Laser Posterior Cordotomy: Is it a Good Choice in Treating Bilateral Vocal Fold Abductor Paralysis?
Authors: Khalil Mahmoud A. , Tawab Hazem M. Abdel 
Published: July 2014

Background Bilateral abductor vocal fold paralysis can lead to respiratory distress and dyspnea. Objectives To assess the efficacy of CO2 laser unilateral posterior cordotomy in cases with bilateral abductor paralysis as regards improvement of dyspnea with preservation of satisfactory voice and swallowing after the operation. Methods A prospective study was done on 18 patients with bilateral abductor vocal fold paralysis (10 females and 8 males) from November 2010 to December 2012 with their ages ranging from 32 to 64 years. Results All patients showed improvement of dyspnea after the operation, most of the patients suffered from mild to moderate dyspnea in the immediate post-operative period, and two patients needed another intervention to solve it. All the patients had satisfactory results of their voice after the operation, and one patient only suffered from temporary aspiration. Conclusion Unilateral CO2 laser posterior cordotomy is an easy and effective procedure to solve the dyspnea after bilateral vocal fold abductor paralysis without aspiration or significant voice alteration.
Inclusão escolar: a perspectiva das mães de alunos com Síndrome de Down
Authors: Smeha Luciane Najar , Oliveira Véra Lúcia Pacheco de 
Published: July 2014

http://dx.doi.org/10.5902/1984686X5908 Este trabalho surge da necessidade de se investigar o que dizem os manuais diagnósticos acerca da deficiência mental, principalmente, no que se refere ao conceito de deficiência mental, aos critérios de diagnóstico e classificação. Na presente pesquisa trabalhou-se com: o Manual Diagnóstico e Estatístico de Transtornos Mentais – DSM-IV (2002); a Classificação Internacional das Doenças – CID-10, (OMS, 1993); a Classificação Internacional de Funcionalidade, Incapacidade e Saúde – CIF, (OMS, 2003); e com Retardo mental: definição, classificação e sistemas de apoio (AAMR, 2002). Os pressupostos teóricos do pensamento sistêmico serviram de ferramenta analítica do material investigado. Foi possível observar uma estreita ligação entre a proposição teórica dos diferentes manuais. Apesar da existência de algumas diferenças, essas mudanças não chegam a produzir uma ruptura epistemológica nas formas de se conceber e identificar o fenômeno em questão, apresentando-se filiada aos pressupostos tradicionais do pensamento científico. Entende-se que a compreensão teórico-conceitual a respeito do fenômeno da deficiência mental traz implicações diretas na proposição e nas configurações das práticas pedagógicas, justificando-se, desta forma, realização desse estudo.
A contribuição da análise de conteúdo nos estudos na área da Educação Especial e sua interface com a prematuridade
Authors: Pizzani Luciana , Lopes Juliana De Fátima , Manzini Mariana Gurian , Martinez Claudia Maria Simões 
Published: July 2014

http://dx.doi.org/10.5902/1984686X6446 OBJETIVOS: Apresentar os procedimentos metodológicos utilizados para elaboração de categorias em estudos na área de interface entre Educação Especial e prematuridade, apoiados na metodologia da análise de conteúdo de Bardin. MÉTODOS: O corpus de análise foram os resumos das teses e dissertações disponibilizadas no Banco de Teses da Capes, envolvendo a temática da prematuridade, recuperados no período de 1987 a 2009. RESULTADOS: Foram selecionados 1173 registros, sendo possível estabelecer duas categorias de objetivos: Temática Principal (TP): estudos cujos assuntos estão ligados diretamente aos indivíduos prematuros; Temática Secundária (TS): estudos cujo tema da prematuridade aparece como fruto ou resultado da pesquisa realizada. CONCLUSÃO: A análise de conteúdo contribuiu para identificar os aspectos mais estudados na área da prematuridade no Brasil, a partir do Banco de Teses da Capes, permitindo visualizar que essa temática tem sido trabalhada em diferentes áreas do conhecimento e por equipes multiprofissionais na tentativa de prevenir ou minimizar as seqüelas incapacitantes através da estimulação e intervenção precoce, já que o nascimento pré-termo pode ser considerado um problema de saúde coletiva devido a sua alta ocorrência em todo o mundo.
A importância da pedagogia nos processos inclusivos
Authors: Hattge Morgana Domênica , Klaus Viviane 
Published: July 2014

http://dx.doi.org/10.5902/1984686X7641 O presente artigo busca, inicialmente, problematizar os processos inclusivos que se estabelecem nos ambientes educativos, com o objetivo de compreender os sentidos que a inclusão escolar assume no cenário educacional e acadêmico contemporâneo. Ao analisar-se uma série de pesquisas que têm como foco a produção do anormal a partir dos diagnósticos e tratamentos clínicos e psicológicos, percebe-se um silenciamento da Pedagogia, que se submete ao saber clínico ou da área psi e acaba por não cumprir sua função na produção de práticas pedagógicas que atendam às necessidades específicas dos sujeitos. Assim, o diagnóstico clínico passa a ser visto como uma verdade absoluta sobre o sujeito, de modo que as intervenções, muitas vezes, são restritas à medicalização. Desse modo, é fundamental refletirmos sobre as relações que se estabelecem entre esses diferentes saberes e seus efeitos nos espaços educativos. Este artigo é um convite à reflexão sobre os desafios da Pedagogia na construção de processos mais inclusivos na área educacional. Palavras-chave: Pedagogia. Saber pedagógico. Processos inclusivos.
Philip dos Civilizados, o selvagem da Selva de Pedra
Authors: Freitas Cláudia Rodrigues de 
Published: July 2014

http://dx.doi.org/10.5902/1984686X8954 Este artigo analisa os modos de organizar a vida e aprendizagens de um menino em situação de sofrimento psíquico e desamparo social, a partir do momento em que é atendido em um espaço escolar. A experiência envolve a tessitura de redes de conversações entre aqueles que convivem com Philip, um menino encaminhado ao Atendimento Educacional Especializado (AEE) a partir do diagnóstico de autismo, uma das formas de dizer no campo do Transtorno Global de Desenvolvimento (TGD). O espaço de acolhimento proposto teve como intenção ampliar a forma de viver e de aprender de Philip. As intervenções surgem e se desenham a partir da invenção do brincar e se tornam visíveis no encontro do olhar, no sorriso, no manuseio dos objetos da vida comum e fundamentalmente na interação com as pessoas ao seu entorno. A inserção e invenção do/no espaço educativo tem o propósito de transformar o sofrimento em vida e possibilidades de aprendizagem. O resultado deste trabalho forja transformações estruturais na convivência entre Philip e todos aqueles em interação com ele. Redes de conversação quando tecidas em rizoma, permitem a construção de saberes capazes de sustentar outro modo de viver. Palavras chave: Inclusão Escolar; Educação Especial; AEE; TGD.
Desafios da implantação do atendimento educacional especializado no Ensino Superior
Authors: Anache Alexandra Ayach , Rovetto Sabrina Stella Maris , Oliveira Regiane Alves de 
Published: July 2014

http://dx.doi.org/10.5902/1984686X9037 Este trabalho teve como objetivo fazer um recorte sobre o Atendimento Educacional Especializado no Ensino Superior, utilizando como base, teóricos que versam sobre a implantação do AEE, desde os anos de 1950 à atualidade. Além disso, apresentaram-se algumas experiências de sucesso, no que se refere à implantação de programas de tecnologias assistivas e de acessibilidade, os quais têm contribuído para entrada, permanência e conclusão do ensino superior por pessoas com necessidades educacionais especiais. A partir do exposto, esta pesquisa teve caráter retrospectivo, descritivo e documentado a respeito da experiência do processo de implantação do AEE em uma instituição de ensino superior. Para tanto, foram utilizados registros em cadernos de campo e documentos escritos, que registraram o conteúdo de entrevistas informais, por meio da técnica da conversação, realizadas com os gestores, diretores, funcionários, professores e alunos, com e sem deficiência desta instituição. Participaram desta etapa de trabalho 238 pessoas, sendo 167 pessoas identificadas como apresentando algum tipo de deficiência e 71 professores, gestores e diretores. A partir deste trabalho, foi possível apresentar a possibilidade de desenvolver diversas ações de ensino, pesquisa e extensão, nos campi da universidade, direcionados às pessoas com necessidades educacionais especiais, apesar dos diversos entraves burocráticos ainda existentes.
« Coupez-le en deux... » (1R 3,25)
Authors: David Robert 
Published: July 2014

La période dite de la « royauté unifiée » en Israël pose de plus en plus de problèmes aux exégètes, aux historiens et aux archéologues. Les débats sont houleux, les positions contradictoires, les arguments évoqués sont utilisés pour soutenir des thèses diamétralement opposées. Le présent article veut présenter quelques données tirées principalement des débats qui ont cours dans le domaine de l’archéologie, qu’il s’agisse du recours à la poterie, au Carbone 14 ou aux inscriptions, entre autres, pour illustrer les tensions qui existent entre les chercheurs, et les difficultés rencontrées quand vient le temps de tenter de présenter un consensus qui rallierait la majorité. L’impasse observée invite à considérer peut-être l’option de s’imposer un moratoire sur les études qui tentent d’établir des liens entre textes bibliques et archéologie.
La communauté paulinienne de Philippes à la lumière de l’archéologie historique
Authors: Baslez Marie-Françoise 
Published: July 2014

L’importance des fouilles archéologiques de Philippes, première fondation paulinienne en Europe, ainsi que leur longue histoire, offre l’occasion de réfléchir sur les rapports entre Bible et archéologie. Le bilan historiographique met en évidence des surinterprétations et des anachronismes, afin de faire « coller » les vestiges au texte des Actes des apôtres ou, au contraire, provoquer la tradition chrétienne en avançant des hypothèses hasardeuses sur de nouvelles découvertes et les silences des textes. À Philippes, l’intérêt historique des inscriptions l’emporte sur celui des vestiges et permet de restituer un contexte religieux et culturel de la mission chrétienne dans la moyenne durée, sinon pour la période précise du passage de l’apôtre. Mais c’est surtout la construction de la mémoire de saint Paul au cours des trois premiers siècles, comme héros fondateur et martyr intercesseur, que les vestiges archéologiques permettent d’étudier.
Increasing Mississippi river discharge throughout the 21st century influenced by changes in climate, land use, and atmospheric CO2
Authors: Tao Bo , Tian Hanqin , Ren Wei , Yang Jia , Yang Qichun , He Ruoying , Cai Weijun , Lohrenz Steven 
Published: July 2014

AbstractPrevious studies have demonstrated that changes in temperature and precipitation (hereafter climate change) would influence river discharge, but the relative importance of climate change, land use, and elevated atmospheric CO2 have not yet been fully investigated. A process‐based projection for the Mississippi River basin suggests that river discharge would be substantially enhanced (10.7–59.8%) by the 2090s compared to the recent decade (2000s), although large discrepancies exist among different climate, atmospheric CO2, and land use change scenarios. Our factorial analyses further indicate that the combined effects of land use change and human‐induced atmospheric CO2 elevation on river discharge would outweigh climate change effect under the high‐emission scenario (A2) of the Intergovernmental Panel for Climate Change, while climate change would still play the dominant role under the low‐emission scenario (B1). This study highlights the important role of anthropogenic factors in influencing future hydrological processes and water resources.
Solar wind‐magnetosphere energy coupling function fitting: Results from a global MHD simulation
Authors: Wang C. , Han J. P. , Li H. , Peng Z. , Richardson J. D. 
Published: July 2014

AbstractQuantitatively estimating the energy input from the solar wind into the magnetosphere on a global scale is still an observational challenge. We perform three‐dimensional magnetohydrodynamic (MHD) simulations to derive the energy coupling function. Based on 240 numerical test runs, the energy coupling function is given by. We study the correlations between the energy coupling function and a wide variety of magnetospheric activity, such as the indices ofDst,Kp,ap,AE,AU,AL, the polar cap index, and the hemispheric auroral power. The results indicate that this energy coupling function gives better correlations than theεfunction. This result is also applied to a storm event under northward interplanetary magnetic field conditions. About 13% of the solar wind kinetic energy is transferred into the magnetosphere and about 35% of the input energy is dissipated in the ionosphere, consistent with previous studies.
Risk and Return Trade‐Offs in Partnering Strategies between Co‐ops and IOFs
Authors: McKee Gregory J. , Wilson William W. , Dahl Bruce 
Published: July 2014

ABSTRACTChanges in grain handling technologies and favorable terms on rail services are encouraging construction of state of the art grain handling facilities. Given these are high fixed and low marginal cost operations that are becoming increasingly vertically interdependent, the investments have substantial risks and opportunities. Partnerships are being formed to capitalize construction of fixed assets, provide a means to share specialized services, or to facilitate acquisitions or mergers. Given the mixture of corporate structures in this industry, including investor owned (IOF) and cooperatives, partnership agreement terms must accommodate the interest of a variety of stakeholder types. The purpose of this paper is to develop a financial model to evaluate classes of these partnerships and then compare distributions of risk and returns to each partner. A stochastic simulation model, specified as being highly representative of some contemporary partnerships, was developed for these purposes. Alternative partnership terms are specified and evaluated.
Quantitative investigation of the adhesion strength between an SU‐8 photoresist and a metal substrate by scratch tests
Authors: Zhang Xiaolei , Du Liqun , Zhao Ming 
Published: July 2014

ABSTRACTDuring the manufacturing process of metal microstructures and microdevices by SU‐8 ultraviolet‐lithographie, galanoformung and abformung (UV–LIGA) technology, interfacial delamination and bond failure are common because of the poor adhesion strength between the SU‐8 photoresist and the metal substrate. In this study, a scratch method was used to measure the adhesion strength between the SU‐8 and the metal substrate. A simulation of a scratch test process was accomplished on the basis of the finite element method, and a modified empirical formula that accounted for local horizontal stress was deduced by a dimensional analysis method. The good agreement among the calculated formula, corresponding simulant, and experimental results showed the validity of the modified empirical formula. Interfacial adhesion work was also obtained to characterize the interfacial adhesion properties. This study provided a theoretical basis for quantitatively estimating the interfacial adhesion strength and a theoretical foundation for improving the interfacial adhesion properties. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41108.
A method for estimating interfacial tension of liquid crystal embedded in polymer matrix forming PDLC
Authors: Deshmukh Rajendra R. , Malik Manoj K. 
Published: July 2014

ABSTRACTA simple and convenient method based on sessile drop technique for measuring surface tensions of polymer and nematic liquid crystal (LC) is described. Contact angles formed by drops of probe liquids and a nematic LC on a photocurable polymer were measured. The surface energies were evaluated using the Fowkes method, Neumann's equation, and new equations developed based on Neumann's approach. The values of surface tensions were used to evaluate the interfacial interaction in term of work of adhesion between the LC and polymer. Further, the effect of dichroic dye on the extent of interaction and work of adhesion was examined by measuring contact angle in consequence of dye addition. A difference in work of adhesion between the lower and higher dye‐doped LC droplets gave an indication of affinity relationship between polymer and LC molecules. A change in work of adhesion resulted in variability of nematic director configurations inside phase separated LC droplets embedded in polymer matrix; when viewed under polarizing optical microscope. Thus, our approach of estimating surface energy of polymer and LC has found to be useful in determining interaction at polymer–LC interface. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41137.
Gamma irradiation synthesis and characterization of AgNP/gelatin/PVA hydrogels for antibacterial wound dressings
Authors: Leawhiran Nuchanan , Pavasant Prasit , Soontornvipart Kumpanart , Supaphol Pitt 
Published: July 2014

ABSTRACTAn antibacterial hydrogel wound dressing was successfully synthesized by the gamma irradiation method. A gelatin solution was mixed with a poly(vinyl alcohol) (PVA) solution of similar concentrations at different weight ratios of 100 : 0, 80 : 20, and 60 : 40 w/w, and irradiated at 30, 40, or 50 kGy. The testing of physical properties showed that the addition of PVA could improve both durability and mechanical integrity. The 60 : 40 hydrogels irradiated at 30 kGy were optimal, and chosen to add silver nitrate at 0.25, 0.50, 0.75, or 1.00 wt % (based on the solid content) to improve the antibacterial properties. After gamma irradiation, silver nanoparticles (AgNPs) were formed. The AgNP/gelatin/PVA hydrogels were characterized for physical properties, cytotoxicity, and antibacterial activity. The AgNP/gelatin/PVA hydrogels could be used as antibacterial wound dressings because they exhibited appropriate physical properties, noncytotoxicity, and could inhibit the growth of tested bacteria. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41138.
Development and evaluation of pressure sensitive adhesives from a fatty ester
Authors: Wu Yili , Li Anlong , Li Kaichang 
Published: July 2014

ABSTRACTNovel pressure sensitive adhesives (PSAs) were developed from renewable methyl oleate (MO) and fully evaluated for their peel strength, tack force and shear resistance. MO was epoxidized and selectively hydrolyzed on the ester group to form epoxidized oleic acid (EOA) that is a bifunctional monomer containing both a carboxylic acid group and an epoxy group. EOA was step‐growth polymerized to form a hydroxyl‐containing polyester, which was then cured in the presence of a small amount of a polyfunctional epoxide [epoxidized soybean oil or trimethylolpropane triglycidyl ether (TMPTGE)] to afford PSAs. The PSAs from the polyester cured with TMPTGE exhibited high peel strength (2.4 N/10 mm), high tack force (5.8 N), and sufficient shear resistance (9.0 min). The PSAs can be fully based on renewable natural materials, and their preparations are environmentally friendly. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41143.
Durability of green polyurethane adhesive bonded aluminum alloy in dry and hydrothermal ageing conditions
Authors: Zain Norazwani Muhammad , Ahmad Sahrim Hj , Ali Ernie Suzana 
Published: July 2014

ABSTRACTPolyurethane (PU) adhesives were prepared from the reaction of polycaprolactone (PCL) polyols based on palm kernel oil based polyesteramide (PPKO) with an aromatic and cycloaliphatic diisocyanate. Four different formulations of PU adhesives were prepared by varying the NCO : OH ratio, in order to investigate the effects of NCO : OH ratios on adhesion strength. The adhesive strength of metal–metal bonding both in dry and hydrothermal ageing—was determined by single lap shear joint testing. The resistance to hydrolysis of the PU adhesives was determined by performing water absorption tests. The water absorption test samples suggested that the durability of the adhesives correlated to lower water absorption due to higher NCO content. The correlation between the crosslinking of the PU network and adhesive strength was also studied by performing swelling tests. The higher NCO content showed that, the higher crosslink density of PUs led to higher cohesion and adhesion strengths. PU1.7 showed optimal properties in terms of durability and resistance to hydrolysis, whereas PU2.0 revealed deterioration in durability and resistance to hydrolysis due to the presence of greater micro‐voids content in the PU2.0 matrix. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 41151.
Structural Evolution of Cu/ZnO Active Sites: From Reactive Environment to Ultrahigh Vacuum
Authors: Xiao Jianping , da Rosa Andreia L. , Zhang Ruiqin , Teoh Wey Yang , Frauenheim Thomas 
Published: July 2014

AbstractBy using first‐principles thermodynamics calculations, we investigate the structural evolution of active sites on Cu/ZnO surfaces from reactive environment to ultrahigh vacuum conditions. Under O‐rich conditions, the formation of active oxygen vacancies on various ZnO surfaces is unfavorable. However, addition of Cu dopants can significantly improve the reducibility of the ZnO nonpolar and polar surfaces, to an extent that ZnO(0 0 0 1)–O polar surface can be fully reduced. The formed oxygen vacancies in turn enhance the charging of Cu active sites on the highly dispersed metallic monolayers containing Cu and Zn. This is believed to be a factor contributing to the synergetic effects of Cu/ZnO catalysts. Irreversible reconstruction of the active metallic monolayers would take place upon removal from the reactive environment and exposure to ultrahigh vacuum condition, resulting in less active Cu overlayers. Therefore, experiments performed directly under UHV conditions may underestimate the activity of the actual catalysts under reactive environment.