bluuebunny/crossref_metadata_2025_split huggingface dataset:
2255 – The Mental Health Risks Economic Crisis In Spain: Evidence From Primary Care Centres, 2006 And 2010
Authors: Gili M. , Roca M. , Stuckler D. , Basu S. , McKee M. 
Published: July 2013

Spain has experienced one of the deepest recessions among European countries affected by the economic crisis. We investigated the effects of the recession on the frequency of mental disorders in Primary Care (PC).A group of PC physicians selected into the study a random sample of patients attending primary care centres. These patients were administered the PRIME-MD for the assessment of mental disorders, in 2006 and again in 2010, before and during the financial crisis. Multivariate logistic regression models were used to assess the relationship of unemployment, mortgage payment difficulties, and eviction on risks of mental health disorders.Compared with the pre-crisis period of 2006, the 2010 survey revealed substantial increases in the proportion of patients with mood, anxiety, somatoform, and alcohol-related disorders (p< 0.0001), but not in eating disorders (p = 0.172). Major depression (19.4% increase) and dysthymia (10.8), showed the greatest rise, followed generalized anxiety disorder (8.4) and panic attack disorder (7.3). Both alcohol dependence and alcohol abuse rose significantly, by 4.6% and 2.4% (OR = 11.6 and 4.5, p< 0.001), respectively. After correcting for the risks of unemployment, we observed a significant rise in attendance with depression associated with mortgage repayment difficulties (OR =2.12, p< 0.001) and evictions (OR = 2.95, p< 0.001).Recession has significantly increased the frequency of mental health disorders, particularly among families experiencing unemployment and mortgage payment difficulties. Expanding mental health services in primary care settings to at-risk groups may help cope with rising mental health disorders in areas affected by recession.
2260 – Gender Profiles Of Cardiovascular Risk Factors Among Highly Educated Community Controls
Authors: Prata J. , Ramos S. , Martins A.Q. , Rocha-Gonçalves F. , Coelho R. 
Published: July 2013

IntroductionWomen remain under-represented in cardiovascular clinical trials even though, in Europe, 55% of female deaths are caused by cardiovascular disease. Women have less extensive and less severe disease but poorer outcome compared to men. Gender related specificities in risk factors and adaptation to illness, or both, might further explain this.MethodsAs part of a larger study examining the impact of depression and type D personality in cardiac patients, a sample of 243 (148 females) highly educated controls (mean age = 41 ± 10 years) were evaluated on demographic, behavioral, psychosocial [BDI-II (Beck Depression Inventory, 2nd edition); HADS (Hamilton Anxiety and Depression Scale); DS-14 (Type D personality)] and clinical risk factors known to be implicated in cardiovascular disease.ResultsWomen had significantly less alcohol consumption (p< .001) and exercise (p< .05), but had higher cholesterol and triglycerides (p < .05) than men. Past psychiatric complaints (p< .05), current depression (p< .05), moderate levels of anxiety (p< .05), and negative affectivity (p< .05) were all significantly more common among women. Age-adjusted multivariate analyses confirmed that lack of exercise together with dietary concerns and increased levels of mental distress (depression, anxiety and negative affectivity) tend to cluster in women. Importantly, no gender differences were detected in traditional cardiovascular risk factors such as hypertension and diabetes, or Type D personality prevalence.ConclusionIn a highly educated sample, women presented with increased behavioral and psychosocial difficulties than men. These vulnerabilities may augment the impact of putative pathophysiological risk factors for cardiac disease.
2261 – Developing Child And Adolescent Mental Health Services In Portugal: Challenges And Obstacles
Authors: Marques C. , Mateus P. , Carvalho Á. , Xavier M. 
Published: July 2013

IntroductionIn 2007 the Government launched a new Mental Health Plan (MHP), written in the spirit of international principles, including the WHO 2001 Global Mental Health Report and the Helsinki European Declaration. The new MHP includes a special section with guidelines for Child and Adolescent Mental Health Services (CAMHS) development. This is relevant, given that, according to WHO, 2 million young people in Europe suffer from mental disorders, sometimes receiving no care.ObjectivesRegarding mental health needs of the children and youth, the MHP focus on i. how to develop new CAMHS in public general hospitals, across the country, and ii. how to integrate CAMHS in the general health system (including primary care), in order to promote access and decrease stigma.MethodsA national task force has been empowered by the Government to assure the implementation of the MHP, with external monitoring from WHO. This task force includes a team of child and adolescent mental health experts, belonging to different administrative catchment areas throughout the country.ResultsRelevant advances have been: appraisal of current resources, development of new CAMHS, planning of residential and day unit facilities for adolescents, mental health promotion and domestic violence prevention programmes, advocacy and stigma.ConclusionsDespite several positive outcomes, CAMHS evaluation detected significant problems (access, equity and quality of care). Special attention should be given to CAMHS, namely through the increase of new services and new teams. Nevertheless, given the present crisis context, broad policies can negatively influence and restraint the mental health plan implementation.
2266 – N4U: a Web-based Gateway To Neuroimaging Research
Authors: Spulber G. , Redolfi A. , Wahlund L.-O. , Cover K. , Finocchiaro C. , McClatchey R. , Maset D. , Mangin J.-F. , Giannakopoulos P. , Toga A. , Evans A. , Frisoni G. 
Published: July 2013

The unprecedented growth, availability and accessibility of sophisticated image analysis algorithms and powerful computational resources led to the idea of developing web-based computational infrastructures that could meet users’ new requirements. On the other hand the gap between the pace of data generation and the capability to extract clinically or scientifically relevant information is rapidly widening.Integration of the power of sophisticated mathematical models, efficient computational algorithms and advanced hardware infrastructure provides the necessary sensitivity to detect, extract and analyze subtle, dynamic and distributed patterns distinguishing one brain from another, and a diseased brain from a normal brain.neuGRID is the leading e-Infrastructure where neuroscientists can find core services and resources for brain image analysis. The neuGRID platform makes use of grid services and computing, and was developed with the final aim of overcoming the hurdles that the average scientist meets when trying to set up advanced experiments in computational neuroimaging, thereby empowering a larger base of scientists. Although originally built for neuroscientists working in the field of AD, the infrastructure is designed to be expandable to services from other medical fields (e.g. multiple sclerosis, psychiatric conditions).“neuGRID for Users” will provide an e-Science environment by further developing and deploying the neuGRID infrastructure to deliver a Virtual Laboratory offering neuroscientists access to a wide range of datasets and algorithm pipelines, access to computational resources, services, and support. Information from this abstract is intended to make aware researchers working with neuroimaging of all possibilities when it comes to resources.
2269 – Evidence For a Negative Association Between Schizophrenia And a Polymorphism In The Insulin Receptor Substrate-3 (irs-3) Gene
Authors: Melkersson K. , Persson B. 
Published: July 2013

IntroductionSince there are clear indications that schizophrenia is a systemic disorder, we sought for a common molecular basis for schizophrenia abnormalities in brain and body. Our hypothesis was that an impaired insulin/ insulin-like growth factor signalling in cells might underlie changes in both brain and body in schizophrenia. In this regard, the intracellular insulin receptor substrates 1-4 proteins might be of interest to study genetically.Objective/aimIn this study, we chose to investigate the insulin receptor substrate-3 (IRS-3) gene as a candidate gene in schizophrenia.MethodsThe IRS-3 gene of 93 patients with the diagnosis of schizophrenia according to DSM-IV criteria and 57 healthy control subjects was screened for DNA sequence variations, followed by case-control analyses of total 10 detected polymorphisms.ResultsThe A/G genotype of the single nucleotide polymorphism (SNP) at position 100166597 in the IRS-3 gene occurred in 5.3% of the control subjects compared with in 0% of the patients (p=0.05).ConclusionOur finding suggests that individuals carrying the A allele of this A/G SNP in the IRS-3 gene have a protection against schizophrenia development.
2270 – Mood And Quality Of Life In Patients With Systemic Sclerosis
Authors: Frikha F. , Masmoudi J. , Messedi N. , Feki I. , Snoussi M. , Jaoua A. , Bahloul Z. 
Published: July 2013

IntroductionSystemic sclerosis (SSc) is a chronic connective tissue reaching the skin and blood vessels, responsible for disability and impaired quality of life.ObjectiveThe objective of this study was to evaluate the quality of life and mood in a group of patients with SSc.MethodsOur study was descriptive, conducted between October 2011 and June 2012; Among the 15 women hospitalized with SSc, 10 agreed to participate in the study. Quality of life was assessed by the WHOQOL BREF scale (World Health Quality of Life-Brief Version). Emotional disorders have been evaluated by the “Hospital Anxiety and Depression Scale” (HAD).ResultsThe average age was 52.4 ± 8.2 years (38-65 years). Our patients were estimated to have a quality of life overall average with a total score scale WHOQOL BREF close to 60 of 120. The values of the four domains were: physical health 46± 8.8 [31-56], psychological health 50.7± 11.2 [31-69], social relations 57.5 ±15.5 [25-75], environment 52 ± 11 [31-63]. Eight women had a score HAD A >10 defining an anxious states certain. Seven patients had a score HAD D > 10 defining a depression certain. 7 out of 10 women said they needed psychological help and were supported jointly in psychiatry.ConclusionOur results underline a high frequency of emotional disorders in patients with SSc. Similarly, the quality of life has been altered. These results suggest a widespread screening for anxiety and depression.
2273 – Attachment Style And Posttraumatic Stress Disorder After Cardiac Surgery
Authors: Parmigiani G. , Tarsitani L. , De Santis V. , Mistretta M. , Zampetti G. , Roselli V. , Vitale D. , Tritapepe L. , Picardi A. , Biondi M. 
Published: July 2013

IntroductionCardiac surgery with cardiopulmonary bypass represents a severe source of stress and has been reported to be associated to the development of Posttraumatic Stress Disorder (PTSD). This disorder leads to a significant disability that might greatly decrease the benefits of surgery. Research rarely focused on the role of attachment styles in the development of PTSD, and no studies addressed this issue in patients undergoing cardiac surgery.ObjectivesTo assess the influence of attachment styles on the development of PTSD.AimsThe identification of specific personological traits predictive of the development of PTSD.MethodsParticipants were recruited among patients scheduled for elective cardiac surgery with cardiopulmonary bypass and evaluated througha)Experiences in Close Relationships (ECR)b)Post-traumatic 10 Stress Symptom Inventory - Modified (PTSS-10)c)Perceived Stress Scale (PSS).Six months after surgery, participants were mailed the PTSS-10 and the PSS. Multiple logistic regression analysis was performed with PTSD as dependent variable, and attachment-related avoidance and anxiety, sex, age and perceived stress as independent variables.ResultsOne hundred twenty-one patients (94% of candidates for elective cardiac surgery who met study inclusion criteria) underwent surgery; 61(59%) were assessed after 6 months. Fourteen subjects (19.7%) scored ≥35 on the PTSS-10 at followup and were considered as having a probable diagnosis of PTSD. Attachment related avoidance at baseline predicted the development of PTSD at follow-up (p< 0.017), after controlling for age, sex and perceived stress.ConclusionsSubjects endorsing the avoidant attachment style are more likely to develop PTSD after cardiac surgery.
2281 – Psychosocial And Overall Effectiveness Of Aripiprazole Once-monthly Vs. Placebo Once-monthly For Maintenance Treatment In Schizophrenia
Authors: Baker R. , Carson W.H. , Perry P. , Sanchez R. , Jin N. , McQuade R.D. , Kane J. , Fleischhacker W.W. 
Published: July 2013

ObjectiveEvaluate the effectiveness of investigational aripiprazole once-monthly (ARI-OM) for maintenance treatment in schizophrenia.MethodsDetailed methodology has been published previously1. Briefly, the study consisted of 4 phases: oral conversion to aripiprazole (Phase 1); oral aripiprazole stabilization (Phase 2); ARI-OM stabilization (Phase 3), with co-administration of oral aripiprazole for the first 2 weeks; and an ARI-OM maintenance phase (Phase 4). Effectiveness assessments included Investigator's Assessment Questionnaire (IAQ) scores, a scale that evaluates effectiveness of current treatment vs. pre-trial medication, where a negative change in score signals improvement, and Personal and Social Performance (PSP) scale scores, where negative change in score signals worsening.Results710 patients entered Phase 2, 576 Phase 3 and 403 Phase 4 (ARI-OM=269, placebo once-monthly [placebo- OM]=134). Mean IAQ Total scores remained stable in Phase 2 (31.3) and Phase 3 (30.6). During Phase 4, the mean change in IAQ Total score was +1.3 for ARI-OM vs. +3.8 for placebo-OM (p< 0.0001). Mean changes in PSP Total scale scores showed improvement during Phase 2 (3.0) and Phase 3 (2.6). Mean change in PSP scores during Phase 4 showed greater functional stability with ARI-OM (−1.7) compared with placebo-OM (−6.2) (p=0.0002 vs. placebo-OM).ConclusionsImprovements in effectiveness, as assessed by the IAQ and PSP Total scale scores, in the Phases 2 & 3 were maintained in Phase 4 for ARI-OM compared with placebo-OM. Treatment with ARI-OM improved symptoms, overall response to treatment and functioning.
2282 – Prevalence Of Children's Mental Health Disorders In Survey Data Compared To Population Data: a Comparison Of Two Prospective Cohorts
Authors: Wong J. , O’Donnell M. , Glauert R. , Bayliss D. , Fletcher J. 
Published: July 2013

IntroductionPrevalence estimates of childhood and adolescent mental health disorders appear to vary between 20 to 30% worldwide. It is therefore unsurprising that studies have yielded inconsistent findings in regards to the trends of prevalence of mental health disorders. Some reasons for the discrepancy in findings include use of survey data and its associated attrition and selection bias.Objectives and aimsFirst, to determine and compare the prevalence of mental health disorders derived from a survey and a population cohort. Second, to evaluate trends of mental health prevalence over time.MethodsAs population data (i.e., linked health records) may be used to overcome the issues presented by survey data, we compared the prevalence estimated from a prospective survey cohort (the Western Australian Pregnancy Cohort (Raine study) to another estimate from a prospective population cohort (linked population data; data from the Hospital Morbidity Records and Mental Health Registration).ResultsAs expected, the Raine cohort yielded a larger estimate of prevalence when compared to the linked population data. However each cohort also revealed opposite trends of prevalence, where the Raine cohort showed the prevalence of mental health disorders to decrease as children age.ConclusionsWe therefore recommend that estimates of prevalence be interpreted with the type of cohort in mind, as estimates from survey cohorts will provide different information to that from population cohorts.
2287 – Size Matters: Investigating The Link Between Affective And Perceptual Body Representations Using Multisensory Illusions
Authors: Preston C. , Ehrsson H. 
Published: July 2013

IntroductionNegative feelings towards the body and body size misperception have long been associated with disordered eating behaviour. Over recent years the perceptual flexibility of the human body representation has been consistently demonstrated using multisensory perceptual illusions. Whether such perceptual changes can impact the emotional experience of our body, however, has yet to be explored.ObjectivesThe current study exploits well-established perceptual body illusions to induce illusory ownership over slimmer and wider body shapes whilst measuring changes in body satisfaction.AimsTo identify a direct causal link between perceptual and affective body representations.MethodsParticipants were presented with video images of both a slimmer and wider mannequin body viewed through head mounted displays from a first person perspective. Illusory ownership was induced by synchronously stroking the seen mannequin body with the unseen real body. Pre and post illusion affective and perceptual measures captured changes in perceive body size and body satisfaction as a result of the illusion.ResultsIllusory ownership of a slimmer body significantly increased feelings of body satisfaction as well as significantly decreasing perceived actual body width. Change in body satisfaction following illusory ownership of a wider body, however, was modulated by degree of sub clinical eating disorder pathology and did not induce a systematic change in perceived body width.ConclusionsThese findings suggest a link between perceived body size and body satisfaction, which may be modulated by eating disorder pathology. The results could have implications for future treatments of eating disorders.
2288 – A 12-week, Randomized, Placebo-controlled Study Evaluating The Efficacy And Safety Of Aripiprazole In Combination With Lithium/valproate Inpartially-responsive Bipolar Mania
Authors: Loze J.-Y. , Landsberg W. , Rollin L. , Eudicone J.M. , Carson W.H. , McQuade R.D. 
Published: July 2013

ObjectiveEvaluate the efficacy of aripiprazole combination with lithium/valproate vs. placebo combination in bipolar mania using a titration regimen with a low starting dose (5 mg/day).MethodsEligible adult patients with bipolar mania receiving lithium/valproate and a Young Mania Rating Scale (YMRS) Total score ≥16 who might benefit from combination treatment with aripiprazole, were randomized to aripiprazole (n=181) or placebo (n=189) with lithium/valproate. Primary endpoint was mean change from baseline to Week 12 in YMRS. Secondary endpoints were Clinical Global Impressions-Bipolar Version (CGI-BP) severity of illness score, response rate (≥50% improvement in YMRS Total score), and remission rate (YMRS ≤12). Safety and tolerability were also assessed. Enrolment yielded a 77% power to detect a 2.6-point change in YMRS Total score at endpoint.ResultsAt endpoint, the mean change in YMRS Total Score (last-observation-carried-forward [LOCF]) for aripiprazole vs. placebo was not significant (treatment difference [-2.04] in favour of aripiprazole (95% CI: -4.14, 0.07; p=0.058). Mean change from baseline to endpoint in CGI-BP showed a treatment difference (-0.30) in favour of aripiprazole vs. placebo (95% CI: - 0.59, -0.01; p=0.044). Response rates were 68.8% vs. 61.3% (p=0.128) and remission rates were 69.9% vs. 64.0% (p=0.211) for aripiprazole and placebo, respectively. No unexpected adverse events (AEs) occurred. Treatment-emergent AEs (≥5% and twice the rate of placebo) were akathisia, depression, and nausea.ConclusionsThe target sample size of 388 patients was not achieved in this study and the primary outcome did not reach statistical significance. Now new or unexpected AEs occurred.
2296 – Insight And Neurocognition In Psychosis: a Comprehensive Meta-analysis
Authors: Nair A. , David A. , Aleman A. 
Published: July 2013

AimsTo complete an up-to-date meta-analysis of studies investigating the correlation between insight and various measures of neurocognition in psychosis.MethodsWe completed a comprehensive literature search using Pubmed and ‘Web of Science’. After applying inclusion and exclusion criteria we isolated 34 papers published on this topic since 2004. This list was then added to those published prior to 2004 that had been found in an earlier meta-analysis performed by our group to give a complete collection of 69 papers. Metaanalysis of data was performed in the Comprehensive Meta-Analysis software using random effects models.ResultsOverall our sample included 5127 patients with psychosis across 69 studies. We performed analyses for overall cognition, IQ, memory, executive function and specifically the Wisconsin Card Sorting Test (WCST). We found a small but highly significant correlation between insight and each measure of neurocognition in all patients with psychosis (mean weighted r = 0.13–0.16 across domains, p < 0.001). When restricted to those patients with diagnosis of schizophrenia (n = 1708) the strength of correlation in each domain increased slightly (mean weighted r = 0.14–0.18, p < 0.01). We found no evidence of significant publication bias.ConclusionIn this comprehensive meta-analysis we found a small but robust correlation between insight and a variety of neurocognitive domains in patients with psychosis. We believe that this data supports the role of neurocognitive processes in some aspects of insight but believe that a more precise experimental approach is required to elucidate the exact mechanisms of this relationship.
2302 – Physicians’ Professional And Personal Experience, Basic Knowledge Of And Attitudes To Suicidal Behavior
Authors: Lasy Y. , Minkevich K. , Vilkockaya N.V. , Zacepin A.O. , Vilkocky E.A. , Naumovskaya N.A. , Pilipenko L.K. 
Published: July 2013

Physicians are well known to confront with suicidal behavior (SB) of their patients frequently in their practice. Suicide risk is higher among doctors in comparison with other professional groups.AimsTo evaluate basic knowledge of physicians about suicide; frequency of suicide events (SE) within their professional practice and personal history; influence of specialty on physicians’ basic knowledge of SB, attitudes to it and frequency of SE.MethodThe questionnaire “Specialist's attitudes to suicide” (developed by authors) has been proposed anonymously to the group of physicians.Results425 copies of questionnaire have been filled (male, N=179, 42.1%). More than 70% of respondents considered suicide to be the consequence of mental disorder. Less than 30% agreed that not only psychiatrists are to be responsible for suicide prevention. 58% has reported the experience of patient's suicide and 67% - of parasuicide in their practice. Over 80% mentioned an emotional influence of suicidal act. Over 15% survive the suicide of their relative or intimate. About 37% of doctors had suicidal thoughts and 8% have reported an act of deliberate self-harm ever in their life. The level of knowledge regarding managing of depressed patients has turned to be unsatisfactory. Psychiatrists were more sensitive in perception of SB of their patients and have reported their own suicidal ideation more frequently than other specialists.ConclusionThe educational programs in the field of depression detection and suicide risk evaluation are needed for physicians. Besides, physicians need psychotherapeutic and psychiatric assistance much more widely than is considered to be.