bluuebunny/crossref_metadata_2025_split huggingface dataset:
Green building development in the US capitals: a focused comparative analysis with Baton Rouge
Authors: Awolesi Oluwafemi , Reams Margaret 
Published: August 2024

Purpose
For over 25 years, the United States Green Building Council (USGBC) has significantly influenced the US sustainable construction through its leadership in energy and environmental design (LEED) certification program. This study aims to delve into how Baton Rouge, Louisiana, fares in green building adoption relative to other US capital cities and regions.

Design/methodology/approach
The study leverages statistical and geospatial analyses of data sourced from the USGBC, among other databases. It scrutinizes Baton Rouge’s LEED criteria performance using the mean percent weighted criteria to pinpoint the LEED criteria most readily achieved. Moreover, unique metrics, such as the certified green building per capita (CGBC), were formulated to facilitate a comparative analysis of green building adoption across various regions.

Findings
Baton Rouge’s CGBC stands at 0.31% (C+), markedly trailing behind the frontrunner, Santa Fe, New Mexico, leading at 3.89% (A+) and in LEED building per capita too. Despite the notable concentration of certified green buildings (CGBs) within Baton Rouge, the city’s green building development appears to be in its infancy. Innovation and design was identified as the most attainable LEED benchmark in Baton Rouge. Additionally, socioeconomic factors, including education and income per capita, were associated with a mild to moderate positive correlation (0.25 = r = 0.36) with the adoption of green building practices across the capitals, while sociocultural infrastructure exhibited a strong positive correlation (r = 0.99).

Practical implications
This study is beneficial to policymakers, urban planners and developers for sustainable urban development and a reference point for subsequent postoccupancy evaluations of CGBs in Baton Rouge and beyond.

Originality/value
This study pioneers the comprehensive analysis of green building adoption rates and probable influencing factors in capital cities in the contiguous US using distinct metrics.
Underexplored food safety hazards of beekeeping products: Key knowledge gaps and suggestions for future research
Authors: Végh Rita , Csóka Mariann , Sörös Csilla , Sipos László 
Published: August 2024

AbstractThese days, a growing consumer demand and scientific interest can be observed for nutraceuticals of natural origin, including apiculture products. Due to the growing emphasis on environmental protection, extensive research has been conducted on the pesticide and heavy metal contamination of bee products; however, less attention is devoted on other food safety aspects. In our review, scientific information on the less‐researched food safety hazards of honey, bee bread, royal jelly, propolis, and beeswax are summarized. Bee products originating from certain plants may inherently contain phytotoxins, like pyrrolizidine alkaloids, tropane alkaloids, matrine alkaloids, grayanotoxins, gelsemium alkaloids, or tutin. Several case studies evidence that bee products can induce allergic responses to sensitive individuals, varying from mild to severe symptoms, including the potentially lethal anaphylaxis. Exposure to high temperature or long storage may lead to the formation of the potentially toxic 5‐hydroxymethylfurfural. Persistent organic pollutants, radionuclides, and microplastics can potentially be transferred to bee products from contaminated environmental sources. And lastly, inappropriate beekeeping practices can lead to the contamination of beekeeping products with harmful microorganisms and mycotoxins. Our review demonstrates the necessity of applying good beekeeping practices in order to protect honeybees and consumers of their products. An important aim of our work is to identify key knowledge gaps regarding the food safety of apiculture products.
Using bioactive compounds to mitigate the formation of typical chemical contaminants generated during the thermal processing of different food matrices
Authors: Guo Zilong , Feng Xiao , He Guangyun , Yang Huanqi , Zhong Tian , Xiao Ying , Yu Xi 
Published: August 2024

AbstractWith rising consumer awareness of health and wellness, the demand for enhanced food safety is rapidly increasing. The generation of chemical contaminants during the thermal processing of food materials, including polycyclic aromatic hydrocarbons, heterocyclic aromatic amines, and acrylamide happens every day in every kitchen all around the world. Unlike extraneous chemical contaminants (e.g., pesticides, herbicides, and chemical fertilizers), these endogenic chemical contaminants occur during the cooking process and cannot be removed before consumption. Therefore, much effort has been invested in searching for ways to reduce such thermally induced chemical contaminants. Recently, the addition of bioactive compounds has been found to be effective and promising. However, no systematic review of this practical science has been made yet. This review aims to summarize the latest applications of bioactive compounds for the control of chemical contaminants during food thermal processing. The underlying generation mechanisms and the toxic effects of these chemical contaminants are discussed in depth to reveal how and why they are suppressed by the addition of certain bioactive ingredients. Examples of specific bioactive compounds, such as phenolic compounds and organic acids, as well as their application scenarios, are outlined. In the end, outlooks and expectations for future development are provided based on a comprehensive summary and reflection of references.
Comprehensive research on the properties of advanced glycation end products in food and biological samples and their harmful role in inducing metabolic diseases
Authors: Gu Min Ji , Lee Yu Ra , Kim Donghwan , Kim Yoonsook , Ha Sang Keun 
Published: August 2024

AbstractAdvanced glycation end products (AGEs) are formed by the Maillard reaction, a nonenzymatic process that occurs widely in cooking, food processing, and within the human body. Primarily, AGEs are formed by the glycation of reducing sugars with amino groups, and this process is heat‐dependent. With changes in lifestyle, there has been an increase in the diversity of dietary habits, including those patterns associated with Western diets, which include the consumption of processed foods that are rich in AGEs. Excessive intake and exposure to AGEs are known to cause abnormalities in body function such as obesity, diabetes, and fatty liver, and the beneficial effects of AGEs in food processing in improving food flavor and quality. To obtain meaningful data regarding AGEs in a variety of food and human samples, it is necessary to more precisely characterize and analyze the AGEs extracted from samples to obtain accurate results. This review explores the recent analytical research and characterization of AGEs in foods, including casein, β‐lactoglobulin, soy protein, and meat protein, and in human samples, such as glycated‐albumin, hemoglobin, and plasma. Additionally, it explores the metabolic fate of AGEs in the body and the mechanisms of disease associated with metabolic abnormalities that may be caused by the consumption of foods containing AGEs. This review aims to provide an overview of the perspectives of relevant recent and future research on metabolic abnormalities caused by foods containing AGEs or by AGEs produced in the body.
Decoding coffee cardiometabolic potential: Chemical composition, nutritional, and health relationships
Authors: Karagöz Mustafa Fevzi , Koçyiğit Emine , Koçak Tevfik , Özturan Şirin Ayçıl , Icer Mehmet Arif , Ağagündüz Duygu , Coreta‐Gomes Filipe 
Published: August 2024

AbstractCoffee is one of the most consumed beverages worldwide, recognized for its unique taste and aroma and for its social and health impacts. Coffee contains a plethora of nutritional and bioactive components, whose content can vary depending on their origin, processing, and extraction methods. Gathered evidence in literature shows that the regular coffee consumption containing functional compounds (e.g., polysaccharides, phenolic compounds, and melanoidins) can have potential beneficial effects on cardiometabolic risk factors such as abdominal adiposity, hyperglycemia, and lipogenesis. On the other hand, coffee compounds, such as caffeine, diterpenes, and advanced glycation end products, may be considered a risk for cardiometabolic health. The present comprehensive review provides up‐to‐date knowledge on the structure–function relationships between different chemical compounds present in coffee, one of the most prevalent beverages present in human diet, and cardiometabolic health.
A comprehensive review of the characterization, host interactions, and stabilization advancements on probiotics: Addressing the challenges in functional food diversification
Authors: Fentie Eskindir Getachew , Lim Kyeongmo , Jeong Minsoo , Shin Jae‐Ho 
Published: August 2024

AbstractThe demand for functional food is rising in tandem with the prevalence of chronic diseases. Probiotics play a crucial role in functional food development, yet their ability to confer health benefits to the host remains a topic of debate according to Food and Agriculture Organization/World Health Organization requirements. The application of culturomics, innovative isolation techniques, within the realm of probiotics is increasingly deemed essential for fully harnessing the latent potential of microbial reservoirs. Nevertheless, its application remains confined predominantly to human fecal sources. Following the integration of probiogenomics, significant advancements have been made in the safety assessment of probiotics. However, the adoption of novel probiotic microorganisms has yet to match the requisite pace. Progress in research concerning host–probiotic interactions by employing omics technologies, particularly in animal models, is notable. Nonetheless, the comprehensive elucidation of mechanisms of action and human trial studies are lagging behind. Additionally, the viability of probiotics, spanning from their production as functional foods to their transit to the human colon, has markedly improved through encapsulation techniques. Nevertheless, opportunities for exploration persist regarding alternative coating materials and diverse encapsulation methodologies. Furthermore, there is a discernible transition in the domain of probiotic‐based functional foods, shifting away from a primarily dairy‐centric focus toward inclusion in a broader array of food categories. This comprehensive review addresses critical issues ranging from isolation sources and novel techniques to the final functional food developments. while doing so, it explores probiogenomics applications for probiotic characterization, investigations into host–probiotic interactions, and strategies for probiotic stabilization under harsh environmental conditions.
Expression, purification, and function of baculovirus infected insect cells‐derived hookworm AIP‐1 and AIP‐2 proteins
Authors: Lee Chae Eun , Chung Hyun Joo , Lee Da Won , Lim Jong Seok , Lee Jeong Hwan , Ko Kisung , Hong Soon Auck , Hong Min Eui , Kim Joo Young , Lee Hye Jun , Kim Jin Wook , Myung Soon Chul 
Published: August 2024

AbstractAnti‐inflammatory protein (AIP)‐1 and AIP‐2, identified as parasite excretory/secretory (ES) proteins, play a crucial role in promoting the survival of the parasite and evading the host immunological response. Both proteins inhibit inflammatory reactions, induce apoptosis in effector cells, and influence the phenotype of the immune response. Numerous parasite‐derived proteins have shown promise as therapeutic targets for inflammatory and allergic diseases. Despite this, the precise biological roles, and molecular characteristics of many such proteins remain unclear.In this study, AIP‐1 and AIP‐2 were produced in the baculovirus‐insect cell expression system (BEVS). The multiplicity of infection (MOI) and the duration of infection conditions for AIP‐1 and AIP‐2 protein expression were successfully optimized to induce the highest expression levels of AIP‐1 and AIP‐2 proteins in insect cells. The insect cell‐derived AIP‐1 and AIP‐2 exhibited inhibitory functions against human matrix metalloproteinases (MMPs). This study demonstrates that insect cell‐derived AIP‐1 and AIP‐2 have the potential as therapeutic proteins for MMP‐TIMP (Metalloprotease‐Tissue inhibitor of metalloprotease) axis related disease.
An ultrasensitive electrochemical method for rapid detection of mercury based on nanoporous gold capped with a novel Zr‐MOF‐SH/reduced graphene oxide aerogel composites
Authors: Wu Xi , Geng Chenggang , Cheng Weiwei , Wang Zhenjiong , Zhang Yan , Wu Di , Tang Xiaozhi 
Published: August 2024

AbstractIn this work, an ultrasensitive electrochemical sensor based on Zr‐MOF‐SH/rGA/NPG was developed for the first time for the rapid determination of mercury ions. First, nanoporous gold (NPG) film was covered on the glassy carbon electrode (GCE) to offer a desirable substrate. Then, Zr‐MOF‐SH/rGA composites were dropped on the NPG film to form a modified electrode. Mercapto functionalized MOFs (Zr‐MOF‐SH) showed strong adsorption capability toward mercury ions, and the unique structure of reduced graphene oxide aerogel (rGA) provided various sites for coupling with Zr‐MOF‐SH as well as improved the electrochemical activity. As a consequence of the synergistic effect of Zr‐MOF‐SH, rGA, and NPG, the optimized Zr‐MOF‐SH/rGA/NPG/GCE sensor showed excellent detection performance toward mercury ions with a linear range from 0 to 200 nM and a low limit of detection of 1.4 nM. Meanwhile, the fabricated electrochemical sensor exhibited outstanding stability, reproducibility, and anti‐interference ability. To verify the practical applicability, the Zr‐MOF‐SH/rGA/NPG/GCE was applied for the determination of mercury ions in real rice samples with desirable recovery rates ranging from 98.8% to 108.3%.
The combined effect of triglyceride–glucose index and high‐sensitivity C‐reactive protein on cardiovascular outcomes in patients with chronic coronary syndrome: A multicenter cohort study
Authors: Li Qinxue , Song Ying , Zhang Zheng , Xu Jingjing , Liu Zhenyu , Tang Xiaofang , Wang Xiaozeng , Chen Yan , Zhang Yongzhen , Zhu Pei , Guo Xiaogang , Jiang Lin , Wang Zhifang , Liu Ru , Wang Qingsheng , Yao Yi , Feng Yingqing , Han Yaling , Yuan Jinqing 
Published: August 2024

AbstractBackgroundThe triglyceride–glucose (TyG) index and high‐sensitivity C‐reactive protein (hsCRP) are the commonly used biomarkers for insulin resistance and systemic inflammation, respectively. We aimed to investigate the combined association of TyG and hsCRP with the major adverse cardiovascular events (MACE) in patients with chronic coronary syndrome (CCS).MethodsA total of 9421 patients with CCS were included in this study. The primary endpoint was defined as a composite of MACE covering all‐cause death, nonfatal myocardial infarction, and revascularization.ResultsDuring the 2‐year follow‐up period, 660 (7.0%) cases of MACE were recorded. Participants were divided equally into three groups according to TyG levels. Compared with the TyG T1 group, the risk of MACE was significantly higher in the TyG T3 group. It is noteworthy that among patients in the highest tertile of TyG, hsCRP >3 mg/L was significantly associated with an increased risk of MACE, whereas the results were not significant in the medium to low TyG groups. When patients were divided into six groups according to hsCRP and TyG, the Cox regression analysis showed that patients in the TyG T3 and hsCRP >3 mg/L group had a significantly higher risk of MACE than those in the TyG T1 and hsCRP ≤3 mg/L group. However, no significant interaction was found between TyG and hsCRP on the risk of MACE.ConclusionOur study suggests that the concurrent assessment of TyG and hsCRP may be valuable in identifying high‐risk populations and guiding management strategies among CCS patients.image
Switch or perish? Prey–predator interactions in a Mediterranean area
Authors: Lazzeri L. , Pacini G. , Belardi I. , Fini G. , De Lillo C. , Ferretti F. 
Published: August 2024

AbstractPredator–prey relationships can influence community processes, and a rich prey spectrum is important to favour carnivore conservation, as well as to buffer single prey towards intensive predation. Antipredator behavioural responses can occur and can be dynamic in time and space, which may generate counter‐responses in predators. However, data are scarce on their role in modulating carnivore diet and behaviour. Data are especially needed for European landscapes that are largely anthropized and have been recently recolonized by large carnivores. In a protected area in central Italy recently recolonized by the wolf and hosting a rich community of wild ungulates, we studied the interactions between this predator and three ungulate species. At the initial stage of wolf recovery, the fallow deer and the wild boar were the main prey, while the roe deer was a minor food item. Through camera‐trapping and predator food habits, we assessed temporal changes in wolf–prey relationships throughout 5 years (2017–2022). Wolf detection rates were spatially associated with those of fallow deer and wild boar, but shrub cover was positively related to predator and negatively to prey, suggesting possible prey avoidance of sites with lower visibility and greater predation risk. Throughout the years, the fallow deer increased its diurnal activity, with a decreasing temporal overlap with the predator. The wolf showed crepuscular/nocturnal activity, with an increased synchronization with the wild boar, which replaced the fallow deer as first prey. No support for major spatiotemporal responses was reported for wild boar and roe deer. With the ongoing recovery of carnivores across Europe, conservation priorities may emphasize the need to maintain an efficient ecological role of predators. Our results support the role of antipredator responses in modulating predator behaviour and diet and emphasize the importance of a diverse spectrum of wild prey to ensure the conservation of the ecological role of carnivores.
Inferring dolphin population status: using unoccupied aerial systems to quantify age‐structure
Authors: Vivier F. , Andrés C. , Gonzalvo J. , Fertitta K. , van Aswegen M. , Foroughirad V. , Mann J. , McEntee M. , Wells R. S. , Bejder L. 
Published: August 2024

AbstractAssessing trends in population abundance and demographics is crucial for managing long‐lived and slow‐reproducing species. Obtaining demographic data, and age‐structure information, is challenging, notably for cetaceans. To address this, we combined Unoccupied Aerial System (UAS; drone) photogrammetry data with long‐term (>20 years) photo identification data to assess the age‐structure of the critically endangered sub‐population of common bottlenose dolphins (Tursiops truncatus) of the Gulf of Ambracia, Greece. We compared our findings with two extensively studied non‐endangered bottlenose dolphin populations (T. aduncus in Shark Bay, Australia, and T. truncatus in Sarasota Bay, USA). Using a log‐linear model, we estimated the total body lengths (TL) of 160 known‐aged dolphins between 2021 and 2023 from blowhole‐to‐dorsal‐fin distance (BHDF) measurements collected during surfacing. Subsequently, we tested four growth models to establish an age‐length growth curve. We assessed the sub‐population's age‐structure using three methods: (1) UAS‐derived TL estimates, (2) age‐length growth curve and (3) long‐term monitoring data (i.e. actual age‐structure). UAS‐measured TL (247.6 ± 32.2 cm) and UAS‐estimated TL (246.0 ± 34.7 cm) of the Greek sub‐population showed no differences. The Richards Growth model suggested an asymptotic length of 258.5 cm. In Greece, resulting age‐structure estimates across the three methods revealed no significant differences (P > 0.1). The Gulf of Ambracia and Shark Bay populations shared similar age‐structures, while Sarasota had higher proportions of 2–10 year‐olds and lower proportions of 10+ year‐olds. All populations had a comparable proportion of 0–2 year‐olds (~14%), indicating a similar reproductive rate. Our findings suggest stability in the Greek sub‐population; however, additional monitoring of reproductive parameters is essential before concluding its status. We demonstrated the effectiveness of UAS‐photogrammetry in rapidly quantifying population age‐structure, including scenarios with limited or no demographic data. This technique shows promise for enhancing precision, timeliness, cost‐effectiveness and efficiency in population monitoring and informing timely conservation management decisions.
Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is a critical regulator of inflammatory signalling through toll‐like receptors 4 and 7/8 in murine and human lungs
Authors: Sayers Ian , Thakker Dhruma , Billington Charlotte , Kreideweiss Stefan , Grundl Marc A. , Bouyssou Thierry , Thamm Sven , Kreuz Sebastian , Hall Ian P. 
Published: August 2024

AbstractBackground and PurposeToll‐like receptors 4 (TLR4) and TLR7/TLR8 play an important role in mediating the inflammatory effects of bacterial and viral pathogens. Interleukin‐1 receptor‐associated kinase 4 (IRAK4) is an important regulator of signalling by toll‐like receptor (TLR) and hence is a potential therapeutic target in diseases characterized by increased lung inflammatory signalling.Experimental ApproachWe used an established murine model of acute lung inflammation, and studied human lung tissue ex vivo, to investigate the effects of inhibiting IRAK4 on lung inflammatory pathways.Key ResultsWe show that TLR4 stimulation produces an inflammatory response characterized by neutrophil influx and tumour necrosis factor‐α (TNF‐α) production in murine lungs and that these responses are markedly reduced in IRAK4 kinase‐dead mice. In addition, we characterize a novel selective IRAK4 inhibitor, BI1543673, and show that this compound can reduce lipopolysaccharide (LPS)‐induced airway inflammation in wild‐type mice. Additionally, BI1543673 reduced inflammatory responses to both TLR4 and TLR7/8 stimulation in human lung tissue studied ex vivo.Conclusion and ImplicationsThese data demonstrate a key role for IRAK4 signalling in lung inflammation and suggest that IRAK4 inhibition has potential utility to treat lung diseases characterized by inflammatory responses driven through TLR4 and TLR7/8.