bluuebunny/crossref_metadata_2025_split huggingface dataset:
Association between Ablation Technology and Asymptomatic Cerebral Injury Following Atrial Fibrillation Ablation
Authors: GUIJIAN LIU , WENQING ZHU , XINGGANG WANG , YING YU , MINGHUI LI , YEQING XIE , RUIZHEN CHEN , JUNBO GE 
Published: June 2014

BackgroundAsymptomatic cerebral injury (ACI) detected by diffusion‐weighted magnetic resonance imaging (MRI) following atrial fibrillation (AF) ablation has been reported recently. The purpose of this study was to provide an overview of the incidence of ACI detected by MRI following AF ablation and to explore the association between ablation technology and ACI by systematically reviewing published trials.Methods and ResultsPubMed, Web of Science, and the Cochrane Library Databases were systematically searched for studies exploring ACI detected by MRI following AF ablation. Incidence of ACI, odds ratios, and 95% confidence intervals (CIs) were pooled. We identified 21 eligible studies. The combined ACI incidence across all studies was 15.9% (95% CI: 0.124–0.202). We also did a subgroup analysis stratified by different technologies. The incidence of ACI stratified by ablation technology was 13.0%, 27.6%, 12.5%, 17.3%, and 32.6% of the irrigated radiofrequency (RF), multielectrode‐phased RF pulmonary vein ablation catheter (PVAC), cryoballoon, laser balloon, and nMARQTM groups, respectively.ConclusionsThe incidence of ACI following AF ablation with PVAC was higher than with other technologies. Uninterrupted oral anticoagulant (OAC) during the procedure could lower the incidence of ACI. It seems prudent not to interrupt OACs during the procedure. In addition, intraprocedural activated clotting time was associated with ACI. Different MRI diagnostic criteria for ACI also influenced the results. To facilitate the future research, a generally accepted definition for silent cerebrovascular ischemia suitable to different kinds of MRI is needed.
A dominant mutation in tyrp1A leads to melanophore death in zebrafish
Authors: Krauss Jana , Geiger‐Rudolph Silke , Koch Iris , Nüsslein‐Volhard Christiane , Irion Uwe 
Published: June 2014

SummaryMelanin biosynthesis in vertebrates depends on the function of three enzymes of the tyrosinase family, tyrosinase (Tyr), tyrosinase‐related protein 1 (Tyrp1), and dopachrome tautomerase (Dct or Tyrp2). Tyrp1 might play an additional role in the survival and proliferation of melanocytes. Here, we describe a mutation in tyrp1A, one of the two tyrp1 paralogs in zebrafish, which causes melanophore death leading to a semi‐dominant phenotype. The mutation, an Arg‐>Cys change in the amino‐terminal part of the protein, is similar to mutations in humans and mice where they lead to blond hair (in melanesians) or dark hair with white bases, respectively. We demonstrate that the phenotype in zebrafish depends on the presence of the mutant protein and on melanin synthesis. Ultrastructural analysis shows that the melanosome morphology and pigment content are altered in the mutants. These structural changes might be the underlying cause for the observed cell death, which, surprisingly, does not result in patterning defects.
Differences in visible light‐induced pigmentation according to wavelengths: a clinical and histological study in comparison with UVB exposure
Authors: Duteil Luc , Cardot‐Leccia Nathalie , Queille‐Roussel Catherine , Maubert Yves , Harmelin Yona , Boukari Fériel , Ambrosetti Damien , Lacour Jean‐Philippe , Passeron Thierry 
Published: June 2014

SummaryThe visible light spectrum is wide, and it can be hypothesized that all the wavelengths between 400–700 nm do not induce the same photobiological effects on pigmentation. We assessed the potential pro‐pigmenting effects of two single wavelengths located at both extremities of the visible spectrum: the blue/violet line (λ = 415 nm) and the red line (λ = 630 nm). We made colorimetric, clinical, and histological assessments with increasing doses of those lights on healthy volunteers. Then, we compared these irradiations to non‐exposed and UVB‐exposed skin. Colorimetric and clinical assessments showed a clear dose effect with the 415‐nm irradiation, in both skin type III and IV subjects, whereas the 630 nm did not induce hyperpigmentation. When compared to UVB irradiation, the blue–violet light induced a significantly more pronounced hyperpigmentation that lasted up to 3 months. Histological examination showed a significant increase of keratinocyte necrosis and p53 with UVB, as compared to 415‐ and 630‐nm exposures.
Kinematics and Subpopulations’ Structure Definition of Blue Fox (Alopex lagopus) Sperm Motility using the ISAS®V1 CASA System
Authors: Soler C , García A , Contell J , Segervall J , Sancho M 
Published: June 2014

ContentsOver recent years, technological advances have brought innovation in assisted reproduction to the agriculture. Fox species are of great economical interest in some countries, but their semen characteristics have not been studied enough. To advance the knowledge of function of fox spermatozoa, five samples were obtained by masturbation, in the breeding season. Kinetic analysis was performed usingISAS®v1 system. Usual kinematic parameters (VCL,VSL,VAP,LIN,STR,WOB,ALHandBCF) were considered. To establish the standardization for the analysis of samples, the minimum number of cells to analyse and the minimum number of fields to capture were defined. In the second step, the presence of subpopulations in blue fox semen was analysed. The minimum number of cells to test was 30, because kinematic parameters remained constant along the groups of analysis. Also, the effectiveness ofISAS®D4C20 counting chamber was studied, showing that the first five squares presented equivalent results, while in the squares six and seven, the kinematic parameters showed a reduction in all of them, but not in the concentration or motility percentage. Kinematic variables were grouped into two principal components (PC). A linear movement characterizedPC1, whilePC2 showed an oscillatory movement. Three subpopulations were found, varying in structure among different animals.
Ghrelin Accelerates In Vitro Maturation of Bovine Oocytes
Authors: Dovolou E , Messinis IE , Periquesta E , Dafopoulos K , Gutierrez‐Adan A , Amiridis GS 
Published: June 2014

ContentsGhrelin, apart from its metabolic role, is nowadays considered as a basic regulator of reproductive functions of mammals, acting at central and gonadal levels. Here, we investigated for possible direct actions of ghrelin on in vitro maturation of bovine oocytes and for its effects on blastocyst yield and quality. In experiment 1, cumulus oocyte complexes (COCs) were matured in the presence of four different concentrations of ghrelin (0, 200, 800 and 2000 pg/ml). In vitro fertilization and embryo culture were carried out in the absence of ghrelin, and blastocyst formation rates were examined on days 7, 8 and 9. In experiment 2, only the 800 pg/ml dose of ghrelin was used. Four groups of COCs were matured for 18 or 24 h (C18, Ghr18, C24 and Ghr24), and subsequently, they were examined for oocyte nuclear maturation and cumulus layer expansion; blastocysts were produced as in experiment 1. The relative mRNA abundance of various genes related to metabolism, oxidation, developmental competence and apoptosis was examined in snap‐frozen cumulus cells, oocytes and day‐7 blastocysts. In experiment 1, ghrelin significantly suppressed blastocyst formation rates. In experiment 2, more ghrelin‐treated oocytes matured for 18 h reached MII compared with controls, while no difference was observed when maturation lasted for 24 h. At 18 and 24 h, the cumulus layer was more expanded in ghrelin‐treated COCs than in the controls. The blastocyst formation rate was higher in Ghr18 (27.7 ± 2.4%) compared with Ghr24 (17.5 ± 2.4%). Differences were detected in various genes’ expression, indicating that in the presence of ghrelin, incubation of COCs for 24 h caused over‐maturation (induced ageing) of oocytes, but formed blastocysts had a higher hatching rate compared with the controls. We infer that ghrelin exerts a specific and direct role on the oocyte, accelerating its maturational process.
Remarkable Rhinophoridae in a growing generic genealogy (Diptera: Calyptratae, Oestroidea)
Authors: CERRETTI PIERFILIPPO , LOGIUDICE GIUSEPPE , PAPE THOMAS 
Published: June 2014

AbstractFour new genera (Apomorphyto gen.n. from Costa Rica, Bixinia gen.n. from Australia, Rhinodonia gen.n. from New Caledonia, Rhinopeza gen.n. from Papua New Guinea) and nine new species (Apomorphyto inbio sp.n., Bixinia collessi sp.n., B. solitaria sp.n., B. spei sp.n., B. variabilis sp.n., B. winkleri sp.n., Rhinodonia antiqua sp.n., R. flavicera sp.n., Rhinopeza gracilis sp.n.) of Rhinophoridae (Diptera: Calyptratae, Oestroidea) are described. All new species were included in a morphology‐based phylogenetic analysis to provide arguments for the justification and monophyly (when nonmonotypic) of the new genera and for including these in the Rhinophoridae. The New Caledonian Rhinodonia is a candidate sister taxon to all other rhinophorids, and the Australasian ‘axiniine’ species emerge inside a clade of all Neotropical taxa thus suggesting migration from South America across Antarctica into Australia.This published work has been registered in ZooBank, http://zoobank.org/urn:lsid:zoobank.org:pub:51C1F448‐DDD0‐4F14‐8173‐B8C687F7E841.
Identification of the carotenoid modifying gene PALE YELLOW PETAL 1 as an essential factor in xanthophyll esterification and yellow flower pigmentation in tomato (Solanum lycopersicum)
Authors: Ariizumi Tohru , Kishimoto Sanae , Kakami Ryo , Maoka Takashi , Hirakawa Hideki , Suzuki Yutaka , Ozeki Yuko , Shirasawa Kenta , Bernillon Stephane , Okabe Yoshihiro , Moing Annick , Asamizu Erika , Rothan Christophe , Ohmiya Akemi , Ezura Hiroshi 
Published: June 2014

SummaryXanthophylls, the pigments responsible for yellow to red coloration, are naturally occurring carotenoid compounds in many colored tissues of plants. These pigments are esterified within the chromoplast; however, little is known about the mechanisms underlying their accumulation in flower organs. In this study, we characterized two allelic tomato (Solanum lycopersicum L.) mutants, pale yellow petal (pyp) 1‐1 and pyp1‐2, that have reduced yellow color intensity in the petals and anthers due to loss‐of‐function mutations. Carotenoid analyses showed that the yellow flower organs of wild‐type tomato contained high levels of xanthophylls that largely consisted of neoxanthin and violaxanthin esterified with myristic and/or palmitic acids. Functional disruption of PYP1 resulted in loss of xanthophyll esters, which was associated with a reduction in the total carotenoid content and disruption of normal chromoplast development. These findings suggest that xanthophyll esterification promotes the sequestration of carotenoids in the chromoplast and that accumulation of these esters is important for normal chromoplast development. Next‐generation sequencing coupled with map‐based positional cloning identified the mutant alleles responsible for the pyp1 phenotype. PYP1 most likely encodes a carotenoid modifying protein that plays a vital role in the production of xanthophyll esters in tomato anthers and petals. Our results provide insight into the molecular mechanism underlying the production of xanthophyll esters in higher plants, thereby shedding light on a longstanding mystery.
Chapter 10 The effect of topography on ash-cloud surge generation and propagation
Authors: Ogburn Sarah E. , Calder Eliza S. , Cole Paul D. , Stinton Adam J. 
Published: June 2014

Abstract
The relationship between valley morphology and ash-cloud surge development for 12 pyroclastic density currents (PDCs) at Soufrière Hills Volcano (SHV), Montserrat is investigated. Channel slope, sinuosity and cross-sectional area were measured from high-resolution digital elevation models (DEMs) using geographical information system (GIS) software; and were compared to geometric parameters of the deposits. The data illustrate three surge-generation regimes: a proximal area of rapid expansion; a medial deflation zone; and a steadier distal surge ‘fringe'. The extent to which these regimes develop varies with flow volume. For larger flows, within the proximal and medial regimes, a strong inverse correlation exists between surge detachment and valley cross-sectional area. Surge detachment is also correlated with observed and modelled flow velocities. Areas of topography-induced increases in velocity are interpreted to result in more pervasive fragmentation and fluidization, and thus enhanced surge generation. Distally, surge deposits appear as fringes with decaying extents, indicative of more passive expansion and decreasing velocity. The results indicate that surge mobility and detachment are a complex product of flow mass flux and topography, and that future efforts to model dense–dilute coupled flows will need to account for and integrate several mechanisms acting on different parts of the flow.
Chapter 12 Geodetic imaging of magma migration at Soufrière Hills Volcano 1995 to 2008
Authors: Elsworth Derek , Foroozan Roozbeh , Taron Joshua , Mattioli Glen S. , Voight Barry 
Published: June 2014

Abstract

We use histories of magma efflux and surface deformation from a continuously operating global positioning system (cGPS) to quantitatively constrain magma transfer within the deep crustal plumbing of the Soufrière Hills Volcano (SHV). Displacement records reach a surface aperture of approximately 11 km and are continuous over three successive cycles of eruption followed by a pause spanning 1995–2008, and we focus on data of this time period. The assumed geometry and flow topology is for twin vertically stacked spherical chambers pierced by a vertical conduit that transmits magma from the deep crust to the surface. For a compressible magma column within an elastic crust we use mean deformation rates measured at between 6 and 13 cGPS stations for periods of effusion then repose and the time-history of magma efflux to define optimal chamber depths and basal magma input. The best fit for a constrained constant basal input to the system is obtained for chambers at 5 and 19 km, and a constant magma input rate of approximately 1.2 m
3
s
−1
. Eruptive then pause episodes are, respectively, characterized by synchronous deflation then inflation of both shallow and deep chambers. Throughout this period of three repeated episodes of effusion then repose, the total effusive volume (
c.
0.95 km
3
dense rock equivalent, DRE) has been sourced half from the lower chamber (
c.
0.5 km
3
) and half from below this chamber (
c.
0.45 km
3
). A consistent observation, repeated through three episodes, is that the eruption restarts as the shallow chamber regains its original volume following the pause and that eruption rearrests when the shallow chamber has deflated by a small but constant volume change (
c.
16–22 Mm
3
). This magmatic metering is consistent with a control on eruption periodicity that involves overpressured breaching of the shallow chamber followed by underpressured sealing. We contrast these observations with other contemporary models that have consistently placed an upper chamber at a depth of approximately 5–6 km, and deeper chambers at 12 km and deeper.
Chapter 13 AVTIS observations of lava dome growth at Soufrière Hills Volcano, Montserrat: 2004 to 2011
Authors: Wadge G. , Macfarlane D. G. , Odbert H. M. , Stinton A. , Robertson D. A. , James M. R. , Pinkerton H. 
Published: June 2014

Abstract
To solve the problem of lava dome growth at Soufrière Hills Volcano (SHV) being invisible and unmeasured owing to cloud, we have designed, built and deployed a ground-based millimetre-wave radar/radiometer: the All-weather Volcano Topography Imaging Sensor (AVTIS). In this chapter, after an outline technical sketch of the instruments, we describe the campaigns between 2004 and 2011 used to test their capabilities. We then present results from the campaigns to illustrate how signals of volcanological interest can be retrieved. The primary measurements of AVTIS are range (to within, at best, about 1 m), and, from that, topography, topographical change and effusion rates, and surface temperature (to within a few degrees Celsius). Changes in radar reflectivity can indicate surface processes (e.g. mass wasting). Surface motion within the instantaneous field of view produces a Doppler signal that allows detection of rockfall. Attenuation of the signal by rain along the path can, when stacked temporally, give an image of rain cloud structure and, by calibration, a rate of rainfall. We regard a strategy of two radars – one permanantly mounted (at Windy Hill) autonomous instrument, and the other used as a rover – as being best for capturing dome growth.
Chapter 14 Continuous and campaign-style gravimetric investigations on Montserrat 2006 to 2009
Authors: Hautmann Stefanie , Gottsmann Joachim , Camacho Antonio G. , Van Camp Michel , Fournier Nicolas 
Published: June 2014

Abstract
Gravimetric time series can provide vital clues about subsurface dynamics associated with active volcanism. Here, we report on continuous and campaign-style gravimetric observations on Montserrat between 2006 and 2009. More than 240 days of continuous gravimetric records enabled us to derive a first local joint solid Earth tides and ocean loading model for Montserrat, and we report the tidal harmonics for 14 major wave groups. Compared to global predictions, the new model (MTY11) achieves an up to one order of magnitude better precision over diurnal and semi-diurnal frequencies. We anticipate that the model will help reduce the effects of tidal perturbations on other geodetic time series recorded on Montserrat. Abrupt variations in gravity accompanied Vulcanian explosions and probably reflect the response of a shallow aquifer to stress changes during pressurization and depressurization of the subvolcanic plumbing system.
Campaign data enabled the quantification of mass variations during a cycle of activity including dome formation and repose. Both forward and inverse modelling of the spatio-temporal time series indicates that the source of the recorded gravity variations is situated beneath central Montserrat. Our favourite interpretation of the campaign data is that the gravity variations reflect volcano-tectonic interaction beneath the Centre Hills of Montserrat that are triggered by changes in the active magmatic system of Soufrière Hills Volcano (SHV). We also discuss our findings on subsurface mass variations in relation to annual precipitation records and active dome formation. Both continuous and discrete gravimetric observations indicate coupling between the dominant magmatic sources responsible for the ongoing eruption at SHV and shallow-seated local sources such as aquifers and fluid-saturated fault-damage zones. Our investigations demonstrate the value of including gravimetric observations over a wide frequency range for volcanic system characterization in a volcanic island arc setting.

Supplementary material:

Details on the inversion routine of the explorative source model GROWTH 2.0 and the resulting images from its application to time-lapse gravity data are available at
http://www.geolsoc.org.uk/SUP18701
.
Chapter 17 Petrological and geochemical variation during the Soufrière Hills eruption, 1995 to 2010
Authors: Christopher Thomas E. , Humphreys Madeleine C. S. , Barclay Jenni , Genareau Kimberly , De Angelis Sarah M. H. , Plail Melissa , Donovan Amy 
Published: June 2014

Abstract
The andesite lava erupted at the Soufrière Hills Volcano (SHV) is crystal-rich with 33–63% phenocrysts of plagioclase (65%), amphibole (28%), orthopyroxene (7%), and minor Fe–Ti oxide and clinopyroxene microphenocrysts. The andesite hosts mafic enclaves that have similar mineral phases to the andesite. The enclaves are generally crystal-poor but can have up to 27% of inherited phenocrysts from the andesite, the majority of which are plagioclase. The eruption is defined by discrete periods of extrusion called phases, separated by pauses. The enclaves exhibit bulk geochemical trends that are consistent with fractionation. We infer that the intruded mafic liquids of Phases I and II interacted and assimilated plutonic residue remaining from the multiple prior mafic intrusions, while the basaltic liquids from Phases III and V assimilated relatively little material. We also infer a change in the basaltic composition coming from depth. The bulk Fe contents of both magma types are coupled and they both show a systematic interphase variation in Fe content. We interpret the coupled Fe variation to be due to contamination of the andesite from the intruding basalt via diffusion and advection processes, resulting in the erupted andesite products bearing the geochemical imprint of the syn-eruptive enclaves.
Chapter 2 Cyclic phenomena at the Soufrière Hills Volcano, Montserrat
Authors: Odbert Henry M. , Stewart Roderick C. , Wadge Geoffrey 
Published: June 2014

Abstract
Cycles of eruptive activity are generally interpreted as evidence of one or more mechanisms operating in equilibrium. Modulation of cycle characteristics thus reflects changes in the conditions affecting those mechanisms. This kind of semi-deterministic behaviour at the Soufrière Hills Volcano has occurred on multiple timescales and with a range of eruptive intensity. By documenting cyclic phenomena, it is possible to investigate the mechanisms that modulate the state of the eruption and examine conceptual models. Pattern recognition and model development allows some degree of short-term forecasting ability for volcanic activity. We report the cyclic eruptive phenomena that have occurred on Montserrat on scales of hours to centuries. We identify four dominant types of cyclicity: sub-daily variations in lava flux; sub-annual cycles in eruption intensity; multi-annual ‘on–off’ switching of lava extrusion; and multi-decadal recurrence of seismic crises. We exploit a wealth of multi-parameter datasets (including seismic, geodetic, thermal, archive and visual observations), and present the evidence and observations for each type of cyclicity, some of which are documented here for the first time. Wavelet time-series analysis is used to constrain cycle characteristics, where appropriate. We discuss the implications of these observations in understanding the eruptive mechanisms of the Soufrière Hills Volcano.

Supplementary material:

Details of all sub-daily cycles are listed in a supplementary table that is available at
http://www.geolsoc.org.uk/SUP18700
.
Chapter 23 Sulphur dioxide diffusion tube monitoring: Soufrière Hills Volcano, Montserrat, 1995 to 2011
Authors: Murrell Caroline , Christopher Thomas E. , Bass Venus , Syers Racquel 
Published: June 2014

Abstract

Sulphur dioxide (SO
2
) diffusion tube monitoring has been undertaken on Montserrat since 1995, providing a unique and insightful long-term dataset of ground-level SO
2
concentrations during the eruption of the Soufrière Hills Volcano (SHV). The monitoring of ground-level SO
2
is important to assess the potential of human exposure to high levels of SO
2
that may impact on health. Air-quality objectives for SO
2
are present in some countries to prevent potential health impacts. Here we summarise diffusion tube monitoring in Montserrat and analyse concentrations with respect to the potential for exposure to levels above recommended levels. We explore relationships that may exist with SO
2
flux measurements and volcanic events. Concentrations have been higher during pauses in lava extrusion. Diffusion tube concentrations are highest within 5 km of the volcano and at locations downwind of the plume. Areas where concentrations have exceeded relevant limits have been uninhabited since 1996. The potential for human exposure above recommended limits is, therefore, currently considered low, as the population would not have been exposed to high concentrations for extended periods of time. Full-time occupation and/or long-term exposure in the areas where concentrations exceed the relevant limits would not be advised.