bluuebunny/crossref_metadata_2025_split huggingface dataset:
Correlation relationships between the levels of microRNA and mRNA involved in pathological angiogenesis in experimental liver cirrhosis
Authors: Lebedeva E. I. , Shchastniy A. T. , Babenka A. S. , Zinovkin D. A. , Nadyrov E. A. 
Published: July 2024

Objective. To identify the relationships between the levels of microRNA and mRNA during pathological angiogenesis under the conditions of experimental toxic liver cirrhosis.Materials and methods. Fibrosis and liver cirrhosis were induced in male Wistar rats using a freshly prepared solution of thioacetamide over 17 weeks. The dynamics of the process were studied at 9 time points. The areas of interlobular veins and interlobular arteries were measured in micrometers. The numbers of interlobular arteries, interlobular veins, and sinusoidal capillaries were counted. The expression levels of mRNA genes Ang, Vegfa, Tweak, Fn14, Notch1, Notch2, and microRNAs-195-5p, microRNAs-664-3p, microRNAs-489-3p, microRNAs-3085, microRNAs-3558-3p in the liver were determined by real-time polymerase chain reaction.Results. It was found that during progressive venous angiogenesis, as well as against the background of changes in the number of interlobular veins, sinusoidal capillaries, and the area of interlobular veins, the nature and strength of correlational interactions between the genes Ang, Vegfa, Tweak, Fn14, Notch1, Notch2, and microRNAs-195-5p, microRNAs-664-3p, microRNAs-489-3p, microRNAs-3085, microRNAs-3558-3p are associated with the stage of fibrosis and liver cirrhosis. Strong, moderate, and mild correlational links (p<0.01) were identified between the genes Ang, Vegfa, Tweak, Fn14, Notch1, Notch2 throughout the experiment.Conclusion. The obtained results indicate that the studied microRNAs - microRNAs-195-5p, microRNAs-664-3p, microRNAs-489-3p, microRNAs-3085, microRNAs-3558-3p - are involved in the processes of restructuring the intrahepatic vascular bed at different stages of experimental toxic fibrosis and liver cirrhosis. The results of the study not only reveal additional mechanisms of formation of the indicated conditions but also identify the biological role of the studied microRNAs in the progression of fibrosis and liver cirrhosis as potential targets for studying pathogenesis and developing treatment methods.
A Few Thoughts About the New Histories of Polish and Latvian Literature
Authors: Jurgutienė Aušra 
Published: July 2024

Being Poland: A New History of Polish Literature and Culture since 1918 (2018), ed. by Tamara Trojanowska, Joanna Nizynska and Przemysław Czapliński; with the assitance of Agnieszka Polakowska, Toronto Buffalo London: University of Toronto Press, 828 p. ISBN 978-1-4426-5018-3(cloth), ISBN 978-1-4875-2459-3 (paper).
A New History of Latvian Literature: The Long Nineteenth Century, eds. Pauls Daija / Bendikts Kalnačs (2022) [Cross-Roads: Studies in Culture, Literary Theory, and History. Ed. by Ryszard Nycz, vol. 29], Peter Lang GmbH, 276 p. ISBN 978-3-631-86202-5 (Print), E-ISBN 978-3-631-85624-6, (E-PDF) E-ISBN 978-3-631-87395-3 (EPUB).
Fa'aliyah Istikhdam al Lu'bah al Lughawiyah Find Me 'Ala Maharah al Istima' Lada al Thollab Bi Madrasah al Mutawassithah al Silamiyyah
Authors: Siti sarah  , Hasibuan Muhammad Syarif Muda 
Published: July 2024

الهدف من هذا البحث معرفة فعالية استخدام اللعبة اللغوية "Find Me" على مهارة الاستماع في الصف الثاني بمدرسة المتوسطة الإسلامية علي بن أبي طالب بندار لابوهان سومطرة الشمالية لتطوير مهارة الاستماع. والمنهج المستخدم هو المدخل الكمي بالنوع التجريبي مع تصميم البحث (True eksperiment) مع تصميم تحكم ما بعد الاختبار فقط (Posttest-Only Control Design). والطريقة المستعملة هي طريقة إحصائية وباستخدام برنامج SPSS 16.0. أما النتيجة الاختبار البعدي للفصل الضابطي 72 وأما النتيجة الاختبار البعدي للفصل التجريبي 83. النتيجة الاختبار-ت (Uji-T) بالتوضيح 2،3 > 2،02 فهذا المراد أنّ الفرض التبادل (Ha) مقبول أو الفرض العدمي (Ho) مردود. والخلاصة أن وجود الفعالية باستخدام اللعبة اللغوية "Find Me" على مهارة الاستماع في الصف الثاني بمدرسة المتوسطة الإسلامية علي بن أبي طالب بندار لابوهان سومطرة الشمالية.
Daur al-Aqraan fi Tarqiyati Mahaarah al-Kalam ladaa Tollab Qism I'dad al-Lughah fi Jami'ah as-Sunnah al-Islamiyah
Authors: Rifky  
Published: July 2024

التفاعل بين الطلاب والأقران له دور مهم في ترقية مهارة الكلام باللغة العربية، وقد يكون دور الأقران في ترقية مهارة الكلام يظهر في داخل الفصل أو خارج الفصل. فالهدف من هذا البحث لوصف دور الأقران في ترقية مهارة الكلام لدى طلاب قسم إعداد اللغة في جامعة السنة الإسلامية بديلي سردنج ، الطريقة المستخدمة هي البحث الوصفي النوعي على سبيل الملاحظة والمقابلة والوثائق و يقوم تحليل البيانات باستخدام طريقة التحليل الوصفي، نتيجة البحث هي : أن الأقران تساعد الطلاب في ترقية مهارة الكلام، فيكون الأقران محاورا في المحادثة باللغة العربية و يكون مشجّعا في ممارسة اللغة العربية ويكون أيضا مقيّما ومصحّحا في الكلام باللغةالعربية بادلاً بمجال المدرس خارج الفصل وتحليل التحديات والعوائق المحتملة ويبحث عن الحلول التي يمكن تطبيقها في البيئة التعليمية، فالخلاصة أن الأقران لها دور مهم في ترقية مهارة الكلام باللغة العربية لدى الطلاب غير ناطقين بها. تؤكد هذه الدراسة على أهمية دور الأقران في تعلم اللغة، خاصة في مهارة الكلام باللغة العربية، وتوفر أساساً لتطوير استراتيجيات تعليمية أكثر فعالية وتفاعلية
Taksir Istikhdam al Lu'bah al Lughowiyah Korrotul ala Mufrodat 'Ala Isti'ab al Mufrodat Bi Al Madrasah al Mutawassitoh al Islamiyah
Authors: Lusi Yana Dewi  , Zaky Ahmad 
Published: July 2024

هدف البحث لمعرفة تأثير استخدام اللعبة اللغوية "كرة المفردات" على استيعاب المفردات في الصف الأول في معهد دار المخلصين سي رامباه بداغاي. والمنهجية المستخدمة هي بمدخل الكمي بالنوع التجريبي مع التصميم مع تصميم البحث True Eksperimental النوع Posttest-Only Contro Design . وطريقة تحليل البيانات هي طريقة الإحصائية و باستخدام برنامج .SPSS 22 ووُجدت النتيجة في استخدام لعبة "كرة المفردات" في الفصل التجريبي بتقدير"جيد جدا" بمعدل النتيجة 75،81. ودرجة قدرة الطلاب بغير استخدام لعبة كرة المفردات في الفصل الضابطي بتقدير "جيد" بمعدل النتيجة 46،75. وجدت الباحثة أن النتيجة 3،306 أكبر من النتيجة وفي معيار 5 في نتيجة 5 % هي 2،069 وفي معيار 1 في نتيجة 1 % هي 2،807. ولذلك يكون فرض التبادلية Alternatif (Ha) مقبولة والعدمية Nihil (Ho) مردودة. فالخلاصة أن الفرض التبادلية Alternatif (Ha) مقبولة والعدمية Nihil (Ho) مردودة.
Airborne observations of upper troposphere and lower stratosphere composition change in active convection producing above-anvil cirrus plumes
Authors: Gordon Andrea E. , Homeyer Cameron R. , Smith Jessica B. , Ueyama Rei , Dean-Day Jonathan M. , Atlas Elliot L. , Smith Kate , Pittman Jasna V. , Sayres David S. , Wilmouth David M. , Pandey Apoorva , St. Clair Jason M. , Hanisco Thomas F. , Hare Jennifer , Hannun Reem A. , Wofsy Steven , Daube Bruce C. , Donnelly Stephen 
Published: July 2024

Abstract. Tropopause-overshooting convection in the midlatitudes provides a rapid transport pathway for air from the lower troposphere to reach the upper troposphere and lower stratosphere (UTLS) and can result in the formation of above-anvil cirrus plumes (AACPs) that significantly hydrate the stratosphere. Such UTLS composition changes alter the radiation budget and impact climate. Novel in situ observations from the NASA Dynamics and Chemistry of the Summer Stratosphere (DCOTSS) field campaign are used in this study to examine UTLS impacts from AACP-generating overshooting convection. Namely, a research flight on 31 May 2022 sampled active convection over the state of Oklahoma for more than 3 h with the NASA ER-2 high-altitude research aircraft. An AACP was bisected during this flight, providing the first such extensive in situ sampling of this phenomenon. The convective observations reveal pronounced changes in air mass composition and stratospheric hydration up to altitudes of 2.3 km above the tropopause and concentrations more than double background levels. Unique dynamic and trace gas signatures were found within the AACP, including enhanced vertical mixing near the AACP edge and a positive correlation between water vapor and ozone. Moreover, the water vapor enhancement within the AACP was found to be limited to the saturation mixing ratio of the low temperature overshoot and AACP air. Comparison with all remaining DCOTSS flights demonstrates that the 31 May 2022 flight had some of the largest tropospheric tracer and water vapor perturbations in the stratosphere and within the AACP.
Wetting and drying trends in the land–atmosphere reservoir of large basins around the world
Authors: Salazar Juan F. , Molina Ruben D. , Zuluaga Jorge I. , Gomez-Velez Jesus D. 
Published: July 2024

Abstract. Global change is altering hydrologic regimes worldwide, including large basins that play a central role in the sustainability of human societies and ecosystems. The basin water budget is a fundamental framework for understanding these basins' sensitivity and future dynamics under changing forcings. In this budget, studies often treat atmospheric processes as external to the basin and assume that atmosphere-related water storage changes are negligible in the long term. These assumptions are potentially misleading in large basins with strong land–atmosphere feedbacks, including terrestrial moisture recycling, which is critical for global water distribution. Here, we introduce the land–atmosphere reservoir (LAR) concept, which includes atmospheric processes as a critical component of the basin water budget and use it to study long-term changes in the water storage of some of the world's largest basins. Our results show significant LAR water storage trends over the last 4 decades, with a marked latitudinal contrast: while low-latitude basins have accumulated water, high-latitude basins have been drying. If they continue, these trends will disrupt the discharge regime and compromise the sustainability of these basins, resulting in widespread impacts.
Flood risk management in planning and construction of city: the Guangzhou experience
Authors: Kuang Minyi , Zheng Yanyan , Deng Xingdong , Yang Yukui , Wang Jingchen , Sui Xintian , Peng Yuan 
Published: July 2024

Abstract. Recently, urban flood disasters caused by rainstorm has happened more and more frequently. Chinese government has proposed that the urban flood disasters problem should be solved by integrated and systematic approach. The analysis of the historical rainstorm flood events of Guangzhou in the past 10 years showed that, the urban rainstorm flood has happened more frequently in lowland, hardening underlying surface and drainage system jacked by high water level. Guangzhou has innovatively delimited high-risk regions by watershed units, using Remote Sensing (RS) data and GIS data, which become the basis of flood risk management. The vertical planning, the storage capacity and river managing boundary have become three important conditions, which should be taken into consideration in the construction projects and serve as the basis for the whole life cycle. As a pioneer, Guangzhou has provided experience for metropolis to reduce flood risk in the construction stage. This paper analyzes the changes and causes of the overall flood safety situation in Guangzhou, and introduces the practice and exploration in Guangzhou from the aspects of promoting the accurate identification of flood risk areas, guiding the spatial control of flood control and drainage safety with planning, establishing the planning transmission mechanism, implementing the flood risk assessment system, and ensuring the transformation of resilient city goals.
The influence of land use and management on the behaviour and persistence of soil organic carbon in a subtropical Ferralsol
Authors: Hondroudakis Laura , Kopittke Peter M. , Dalal Ram C. , Barnard Meghan , Weng Zhe H. 
Published: July 2024

Abstract. A substantial carbon (C) debt has been accrued due to long-term cropping for global food production emitting carbon dioxide from soil. However, the factors regulating the persistence of soil organic C (SOC) remain unclear, with this hindering our ability to develop effective land management strategies to sequester organic C in soil. Using a Ferralsol from semi-arid subtropical Australia, alteration of bulk C contents and fractions due to long-term land use change (up to 72 years) was examined with a focus on understanding whether SOC lost due to cropping could be restored by subsequent conversion back to pasture or plantation. It was found that use of soil from cropping for 72 years resulted in the loss of >70 % of both C and N contents. Although conversion of cropped soil to pasture or plantation for up to 39 years resulted in an increase in both C and N, the C contents of all soil fractions were not restored to the original values observed under remnant vegetation. The loss of C with cropping was most pronounced from the particulate organic matter fraction, whilst in contrast, the portion of the C that bound strongly to the soil mineral particles (i.e. the mineral-associated fraction) was most resilient. Indeed, aliphatic C was enriched in the fine fraction of mineral-associated organic matter (<53 µm). Our findings were further confirmed using Synchrotron-based micro-spectroscopic analyses of intact microaggregates, which highlighted that binding of C to soil mineral particles is critical to SOC persistence in disturbed soil. The results of the present study extend our conceptual understanding of C dynamics and behaviour at the fine scale where C is stabilized and accrued, but it is clear that restoring C in soils in semi-arid landscapes of subtropical regions poses a challenge.
Analisis Potensi Biogas dari Limbah Kotoran Sapi di Kabupaten dan Kota Sukabumi
Authors: Rizaldi Ardi , Ali Mukhlis 
Published: July 2024

Salah satu usaha sampingan di Indonesia peternakan sapi berkisar skala kepemilikan 3-4 ekor per rumah tangga, begitupun dengan Sukabumi yang memiliki nilai yang cukup tinggi mencapai 28.729 ekor. Penelitian ini bertujuan untuk: (1) untuk mengetahui potensi biogas dari kotoran sapi (2) untuk mengetahui perbandingan/klasifikasi potensi biogas per Kecamatan, (3) untuk mengetahui ekivalensi energi biogas dengan lpg 3kg di Kabupaten dan Kota sukabumi, dan (4) untuk mengetahui tingkat kepuasan pengguna peta digital potensi biogas dari limbah kotoran sapi di Kabupaten dan Kota Sukabumi. Studi literatur digunakan sebagai acuan landasan teori pada penelitian ini. Potensi kotoran sapi di kabupaten dan kota Sukabumi diklasifikasikan menjadi 3 kategori yaitu rendah, sedang dan tinggi. Dari hasil analisis yang dilakukan terhadap 54 kecamatan yang ada, terdapat 14 kecamatan dengan kategori tinggi, 14 kecamatan dengan kategori rendah, dan sisanya masuk kategori sedang. Ekivalensi biogas Kabupaten dan Kota Sukabumi sebesar 2643,1 setara denga 881 tabung lpg. yang paling banyak terdapat pada Kecamatan Ciracap sebesar 370,2 , yang paling sedikit terdapat pada Kecamatan Warudoyong . Peta digital potensi biogas di uji oleh 3 kategori yaitu: Lembaga Pemerintaha dan Mahasiswai, dari 35 responden masing-masing kategori dengan membagikan link https://petabiogassukabumi.com/ dnegan menjawab 6 pertanyaan dalam kuisioner. Hasil pengisian kuisioner dari semua kategori diperoleh dengan skor uji kepuasan pengguna >80%. Hal ini menunjukan uji penggunaan peta digital di anggap puas berdasarkan tingkat kepuasan pengguna dan secara fungsi dari peta digital tersebut.
Analisa Perencanaan dan Pengendalian Persediaan Bahan Baku Pembuatan Interior Set pada CV. Advisia Diantara Palembang
Authors: Hasyunah  , Siti Hasania  
Published: July 2024

Abstract : This study aims to determine the effect of skills, knowledge, motivation, and abilities on the performance of UMKM Bakso employees in Semarang City. The population studied was 385 employees. This study uses SPSS software with multiple regression tests as a hypothesis testing method. The results of the analysis and discussion show that the variable has a partial effect, namely Skills has a positive and significant effect on the performance of UMKM Bakso employees in Semarang City. Knowledge has a positive and significant effect on the performance of UMKM Bakso employees in Semarang City. Motivation has a positive and significant effect on the performance of UMKM Bakso employees in Semarang City and Ability has a positive and significant effect on the performance of UMKM Bakso employees in Semarang City.
Abstrak : Tujuan Penelitian adalah untuk mengetahui dan menganalisa perencanaan dan pengendalian persediaan pada CV Advisia Diantara Palembang. Data yang digunakan dalam penelitian ini adalah data primer dan data sekunder. Populasi penelitian ini adalah laporan pelaksanaan perencanaan dan pengendalian persediaan bahan baku proyek interior set milik CV Advisia Diantara Palembang dari tahun sejak berdirinya perusahaan sampai tahun 2017. sampel yang digunakan adalah laporan pelaksanaan perencanaan dan pengendalian persediaan bahan baku proyek interior set yang telah selesai dari tahun 2016 sampai tahun 2017. Sampling yang digunakan dalam penelitian adalah purposive sampling. Hasil penelitian menunjukkan bahwa selama ini perusahaan belum melaksanakan perencanaan dan pengendalian atas pengadaan bahan baku dengan baik di dalam suatu pembelian dan perusahaan. Berdasarkan permasalahan yang dihadapi perusahaan tersebut maka penulis menyarankan agar perusahaan CV Advisia Diantara Palembang memperhatikan perencanaan dan pengendalian persediaan barang yang baik untuk menunjang kegiatan operasional perusahaan sehingga efektivitas dan tujuan perusahaan yang telah ditetapkan dapat tercapai.
Морфометрический анализ рельефа северо-западной части Тамбовской области
Authors: Буковский Михаил Евгеньевич , Кузьмин Кирилл Алексеевич 
Published: July 2024

Хорошо освоенная территория Окско-Донской равнины, в пределах которой расположена Тамбовская область, служит одним из важнейших районов аграрного производства страны. С точки зрения экологически устойчивого функционирования агроландшафтов, занимающих большую часть области, а также ответственного управления земельными ресурсами, актуальна задача комплексной оценки земельного фонда региона. В статье представлены результаты морфометрического анализа рельефа двух муниципальных округов на северо-западе Тамбовской области. Инструментами ГИС-приложений построена цифровая модель рельефа с пространственным разрешением ячейки 30 м, составлены гипсометрическая карта, морфометрические карты крутизны, экспозиции склонов, эрозионного потенциала рельефа (LS-фактора). Для территорий изученных муниципальных округов рассчитаны средневзвешенные значения абсолютной высоты, уклона, LS-фактора, а также степень вертикального и горизонтального расчленения рельефа. Исследованные территории северо-запада Тамбовской области отличаются равнинным рельефом с преобладающими уклонами местности менее 0,5°, слабой расчленённостью и малыми значениями оценок эрозионного потенциала. Результаты работы могут найти применение при организации рационального землепользования, картографированные значения морфометрических характеристик могут стать первичными материалами для проектирования адаптивно-ландшафтных систем земледелия на региональном уровне. Данные об эрозионном потенциале рельефа будут использованы для расчётов эрозионных потерь почвы от талой, дождевой, ирригационной эрозии.
Фауна жуков-долгоносиков (Coleoptera, Curculionidae) Белгородской области
Authors: Присный Александр Владимирович , Мирошников Андрей Николаевич , Присный Юрий Александрович 
Published: July 2024

На основе анализа коллекционных материалов и известных данных составлен видовой список жуков-долгоносиков (Curculionidae) Белгородской области, включающий 331 вид. Для 324 видов приводится информация о месте и времени сбора. Впервые для территории области приводятся данные о 37 видах.
Variante no reportada del gen THRB en un paciente con resistencia a hormonas tiroideas
Authors: Builes Montaño Carlos Esteban , Arroyo Ripoll Oriana F. , Contreras Saldarriaga Jorge E. 
Published: July 2024

Introducción: las variantes en el gen del receptor de hormona tiroidea beta son la principal causa del síndrome de resistencia a las hormonas tiroideas (RHT), donde la herencia es autosómica dominante y se caracteriza por un descenso en la sensibilidad de los tejidos a las hormonas tiroideas, además, las manifestaciones clínicas son variables con síntomas de hiper o de hipotiroidismo.
Objetivo: documentar una variante genética potencialmente patogénica del gen receptor de hormona tiroidea beta relacionada con síndrome de RHT no reportada en la literatura y proporcionar información sobre el abordaje diagnóstico.
Presentación del caso: masculino de 43 años con síntomas de hipertiroidismo a quien se le documentaron niveles elevados de T4 libre con una TSH inapropiadamente normal, resonancia magnética de silla turca simple y contrastada sin lesiones en la hipófisis y prueba de estímulo con TRH con respuesta adecuada, indicando un diagnóstico presuntivo de RHT, además, el estudio genético reveló una variante: c.1046_1047insCCTGGT (p.Val349_Ser350insLeuVal) en el gen THR-B, Se procedió al análisis bioinformático de la proteína, indicando ser patogénica con una confianza del 89,4?%.
Discusión y conclusión: la sospecha diagnóstica está dada por la discrepancia en los valores de tirotropina, tiroxina y triyodotironina, por lo que realizó un abordaje diagnóstico completo que descartó la interferencia en los ensayos, anormalidades del transporte de las hormonas tiroideas y en la tirotropinoma; la prueba de estímulo con TRH orientó el diagnóstico y la prueba genética su confirmación. Así, reportamos una nueva mutación relacionada con el fenotipo de síndrome resistencia a las hormonas tiroideas, donde este caso demostró la importancia de hacer énfasis en la evaluación genética.
Cultural Jugaad in Historic City Transformations: India
Authors: Fookes Ian , Jain Shikha 
Published: July 2024

Several historic Indian cities have managed to retain the original urban character by using readily available materials, craftspeople, and cultural traditions despite increasing urban transformations. This notion of sustaining/preserving/continuing certain cultural elements and rituals has survived in various forms in the last two centuries. Historic cities showcase their living heritage at the global level and are exemplars for studying the strong linkages within traditions and indigenous modes of preservation. In such situations where stakeholders have centuries of association with the site, it is essential that professionals look beyond conventional solutions to better understand local perceptions and thereby establish the appropriateness of any urban level interventions.

This article draws from various urban conservation works carried out in the historic cities of Rajasthan over the last two decades. It illustrates the discoveries and challenges in understanding the traditional local mindset for working in such areas. The indigenous methods practiced in these historic living cores are often at variance with the norms and logics of Western city planning being followed in post-colonial India. Examples in the cities and settlements of Jaipur, Udaipur and Ajmer, feature in this article, highlighting the urgent need to understand the local community mindset and the Indian approach to solutions for rapidly modernizing historic urban centres.