bluuebunny/crossref_metadata_2025_split huggingface dataset:
Unveiling the Barriers to Digital Transformation in Higher Education Institutions: A Systematic Literature Review
Authors: Si Amando Jr. Pimentel 
Published: August 2024

Abstract

This study investigates the challenges hindering the implementation of Digital Transformation (DT) in Higher Education Institutions (HEIs) by thoroughly reviewing the literature. It identifies multiple dimensions and subdimensions of these barriers to offer valuable insights to help HEIs navigate their transformation processes successfully. By doing so, they can effectively address the changing requirements of students and society in an increasingly digital environment. This study followed the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, synthesizing data from 20 relevant peer-reviewed articles published between 2019 and 2024. NVivo and Zotero were utilized as methodological instruments for coding, thematic analysis, and text mining to extract insights from the chosen articles to construct a Concept-centric Matrix on Barriers to Digital Transformation (DT) in Higher Education Institutions (HEIs). The result of this study is summarized in a Concept-centric Matrix on Barriers to DT in HEIs consisting of nine (9) dimensions such as (i) Digital Vision, Strategy, and Policies; (ii) Digital Leadership and Management; (iii) Digital Organization; (iv) Digital Resources; (v) Digital Competence; (vi) Digital Stakeholder Management; (vii) Digital Culture; (viii) Digital Academic; and (ix) Digital Ethics. Each dimension has subdimensions of barriers (n=80). Despite various sectors anticipating significant disruption from DT, many HEIs feel inadequately prepared to adapt because of the barriers to its implementation. The ongoing DT within HEIs reveals a complex landscape marked by various intertwined barriers that necessitate a strategic reevaluation and a commitment to fostering an inclusive, responsive educational environment.
Comparative Review of Single-Criteria and Multi-Criteria Optimisation Problems using Meta-heuristic Algorithms.
Authors: Okechukwu Cornelius , Silhavy Radek , Oyelere Solomon , Silhavy Petr 
Published: August 2024

Abstract

This paper explores using metaheuristic algorithms for single-criteria optimisation problems (SCOP) and multi-criteria optimisation problems (MCOP). It highlights the critical differences between these types, noting that SCOP focusses on a single objective while MCOP deals with conflicting goals. We applied metaheuristic algorithms inspired by natural phenomena to both problem types and provided a table comparing generic algorithms with problem-specific adaptations (PSAs), including their applications. A case study customised a contemporary algorithm for the Traveling Salesman Problem (TSP) using Genetic Algorithms (GA). At the same time, another examined the differences between generic algorithms and PSAs in a multi-criteria context with the Multi-Objective Knapsack Problem, utilising Multi-Objective Genetic Algorithms (MOGA) and Multi-Objective Particle Swarm Optimisation (MOPSO) alongside their tailored versions. The results indicate that PSAs outperform generic algorithms in SCOPs. The GA for TSP reduced the total journey distance over the generations, indicating progress towards optimal solutions. Similarly, in MCOP, tailored algorithms produced higher quality Pareto fronts, with better average hypervolume values and lower standard deviations than generic alternatives. We also discuss recent advancements and suggest future research directions for enhancing metaheuristic applications in optimisation.
Evaluating and Enhancing the Tourism Attraction of Phu Quoc Island: An Ecological Economic Approach Integrated with AI and Big Data Analytics
Authors: Ngo-Hoang Dai-Long 
Published: August 2024

Abstract

Phu Quoc Island, Vietnam's largest island, is celebrated for its stunning natural landscapes and rich cultural heritage. This study introduces an innovative approach to evaluating the factors contributing to Phu Quoc's tourism attraction by combining a modified gravitational model with ecological economic principles, Artificial Intelligence (AI), and Big Data analytics. By incorporating real-time data on biodiversity, carbon emissions, renewable energy usage, and tourist behavior, the study provides a comprehensive framework for promoting sustainable tourism on the island. The findings offer actionable insights and a strategic roadmap for enhancing Phu Quoc's appeal as a green and sustainable tourist destination, ensuring long-term economic and environmental benefits.
Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance
Authors: Zhou Peng , Kasai Rinshi S. , Fujita Wakako , Tsunoyama Taka A. , Ueda Hiroshi , Pigolotti Simone , Fujiwara Takahiro K. , Kusumi Akihiro 
Published: August 2024

Abstract

Heterodimerization of opioid receptors (ORs), MOR, KOR, and DOR, is implied in their functional regulation and diversification, and thus its understanding is crucial for developing better analgesic treatments. However, our knowledge on OR heterodimerization/heterodimers remains limited. Here, using single-molecule imaging and functional analysis, we found that MOR, the main morphine receptor, repeatedly forms transient (≈250 ms) heterodimers with DOR every 1-10 seconds, but not with KOR, whereas DOR and KOR also form transient heterodimers. We obtained all the heterodimer-monomer equilibrium constants and rate constants with/without agonists. We identified the critical heterodimer binding sites in the extracellular domains, in addition to the less-specific transmembrane domains, and developed soluble peptide blockers for MOR-DOR and DOR-KOR heterodimerization, using amino-acid sequences mimicking the extracellular binding sites. With these peptide blockers, we dissected the monomer/dimer roles in OR internalization and signaling. The soluble MOR-DOR heterodimer blocker reduced the development of long-term morphine tolerance in mice.
SAÚDE MENTAL DOS ESTUDANTES DE MEDICINA: CARACTERÍSTICAS INDIVIDUAIS, SOCIOECONÔMICAS E CONTEXTUAIS
Authors: Lima Jogiely Larissa Ferreira , Rabelo Paulo Wictor Lima , Machado Yuri de Castro 
Published: August 2024

Transtornos mentais são muito comuns em estudantes de medicina, sejam por fatores acadêmicos, individuais ou sociais que potencialmente geram esse adoecimento mental. Este artigo apresenta como objetivo analisar os fatores de risco para desenvolvimento de doença mental no estudante de medicina, bem como avaliar os métodos de prevenção e controle do adoecimento mental nesse grupo de estudantes. Trata-se de uma revisão integrativa da literatura, para realização das pesquisas foram utilizadas as bases de dados: PubMed, Science Direct e BVS/MEDLINE. O processo de triagem contou com os seguintes critérios de inclusão: artigos que respondessem à pergunta de pesquisa, em inglês e que foram publicados entre 2017 a 2022. Como resultado, foi obtido um total de 12 estudos. A prevalência mundial de ansiedade identificada nos estudantes de medicina está aumentando exponencialmente a cada ano, sendo a taxa de cerca de 33,8%, variando entre 29,2% a 38,7%, sendo considerada substancialmente maior do que quando comparada com a população geral que variou de 3% a 25% conforme as escalas de rastreio para ansiedade e depressão. A carga excessiva de trabalhos acadêmicos, com consequente privação de sono, o baixo nível socioeconômico, a exposição a mortes de pacientes e os professores abusivos foram identificados como prováveis razões para as altas taxas de ansiedade dos estudantes de medicina. Além disso, foi identificada uma taxa de aproximadamente 9,5% da síndrome de Burnout nos acadêmicos de medicina, sendo 50% associados a fatores pessoais, 42% relacionados ao trabalho/ estudos e 12% relacionados ao paciente. O presente estudo reafirma a necessidade da aplicação dos métodos de prevenção e controle pelas instituições de ensino, a fim de reduzir as taxas de incidência dos transtornos mentais nos acadêmicos de medicina e gerar uma melhoria na qualidade de vida, no desempenho acadêmico, no profissionalismo e na empatia em relação aos pacientes.
A CONSTRUÇÃO DE UM MODELO INTERDISCIPLINAR PARA A PROMOÇÃO DA SAÚDE DO SERVIDOR PÚBLICO EM UMA UNIVERSIDADE FEDERAL
Authors: Carolina Meira Moser  , Gislaine Thompson Dos Santos  , Mariana Bello Porciuncula  , Mariana Valls Atz  , Milton Humberto Schanes Dos Santos  , Ana Carolina Brondani  , Rogério Miranda Barros  , Carine Gatto  , Djanir De Freitas Brião  , Glaci Rodrigues Leal  , Viviane Cordova Jardim Votto  , Viviane Fernandes Silveira Almeida  , Patrícia Costa Azevedo  , José Menna Oliveira  , Maria De Lourdes Giacomini  
Published: August 2024

A promoção à saúde do servidor público federal objetiva melhorar processos de trabalho e ambientes organizacionais, mediante abordagens coletivas que influenciem ou modifiquem hábitos. O objeto deste trabalho é a trajetória da Divisão de Promoção da Saúde (DPS) da Universidade Federal do Rio Grande do Sul, que apresentou mudanças significativas em sua micropolítica de trabalho. Objetiva-se relatar a experiência das ações desenvolvidas pela DPS em sua atual configuração, mediante a descrição da transposição de uma lógica assistencial e fragmentada, para uma em que a saúde do servidor é entendida em uma dimensão ampla e integrada. A DPS resulta da união de um serviço de enfermagem, que atuava em ações de vacinação e procedimentos; e uma divisão de atenção psicossocial que acompanhava servidores com questões de saúde relacionadas ao trabalho. Posteriormente, uniram-se à equipe outros profissionais, mas o caráter individual dos processos de trabalho ainda era predominante. Com a pandemia da COVID-19, a equipe passou a realizar reuniões semanais, facilitando a adesão ao formato de teletrabalho e viabilizando a promoção de discussões sobre o papel do setor, o alcance das atividades e a divisão de tarefas. Esse contexto, aliado também à mudança de chefia, permitiu a transformação do trabalho para um modelo mais democrático, colaborativo, dialógico e interdisciplinar. Nos últimos três anos, diversos trabalhos foram desenvolvidos: projetos de educação para saúde; atendimentos psicossociais e intervenções em equipes; ações de capacitação; materiais de divulgação, redes sociais e podcast; criação de Programa de Apoio a Gestantes, Lactantes e Adotantes; reconfiguração de Programa de Educação para Aposentadoria; e realização de Censo de Saúde. Observa-se que os atores envolvidos, frente às modificações institucionais causadas pela reestruturação organizacional e pela pandemia, potencializaram suas ações frente às adversidades, utilizando-se de momentos intercessores para o fomento de novos paradigmas.
EDUCAÇÃO EM SAÚDE BUCAL PARA TRABALHADORES DE INDÚSTRIA ALIMENTÍCIA DE BISCOITOS: RELATO DE EXPERIÊNCIA EXTENSIONISTA
Authors: Silva Junior Manoelito Ferreira , Costa Clara Letícia Moreira , Silva Beatriz Xavier , Barreto Camila Souza , Lemos Camila Santos , Pimentel Eduarda Silva Meira , Silva Gabriel Barra , Abreu Júlia Flores 
Published: August 2024

As principais doenças bucais são derivadas do biofilme microbiano, e por isso, o tipo de alimentação modula sua patogenicidade. Sendo assim, trabalhadores da indústria alimentícia, como de biscoitos, podem apresentar maior consumo de carboidratos fermentáveis, e por isso, apresentam maior risco das doenças bucais. O objetivo foi relatar uma ação extensionista de educação em saúde bucal para trabalhadores de uma indústria alimentícia de biscoitos. A ação extensionista do ‘Projeto Sorrir: Promoção de saúde bucal por ciclos de vida e grupos vulneráveis’ foi realizada com trabalhadores da empresa Biscoitos Bispo, em maio de 2023, na Associação de Padeiros, no município de Jequié/BA. A atividade foi planejada e executada por seis acadêmicos e um docente do curso de Odontologia da Universidade Estadual do Sudoeste da Bahia, Jequié/BA. A atividade proposta foi planejada em quatro momentos: 1) uso de recursos visuais para sensibilização / conceituação / exemplificação sobre importância do sorriso saudável, impacto do consumo frequente de carboidratos na saúde bucal e relação custo-efetividade da prevenção; 2) dinâmica de mitos e verdades com oito assertivas para problematização dos principais itens de higiene bucal (dentifrício, escova, fio dental e enxaguante), doenças e agravos bucais (cárie dentária, doença periodontal e perda dentária); 3) momento tira-dúvidas; e, 4) demonstrações com macromodelos bucais e instrumentos de higienização bucal. A ação com duração de uma hora teve a participação de 16 pessoas, quinze homens e uma mulher, sendo a maioria adultos jovens. Os diferentes métodos educativos utilizados foram efetivos. O uso de imagens do impacto do sorriso trouxe maior atenção sobre o tema. A dinâmica de mitos e verdades mostrou o baixo conhecimento sobre os itens de higiene e agravos bucais. No momento tira-dúvidas, os participantes interagiram com experiências e assuntos ainda não contemplados, tais como: busca do serviço odontológico, dor de dente e dente siso. Por meio das demonstrações das técnicas de higiene bucal, identificou-se a baixa adesão do uso do fio dental, ou ainda, de movimentos ântero-posteriores incorretos na escovação dos dentes. Conclui-se que a ação demonstrou o impacto da saúde bucal no bem-estar e contribuiu para conscientizar os trabalhadores sobre a relevância do cuidado bucal e adoção de hábitos saudáveis. Ainda, a elaboração e execução da atividade educativa para os trabalhadores da indústria alimentícia, estimulou o pensamento crítico e reflexivo dos acadêmicos para atender as especificidades de um público-alvo pouco explorado e alcançado pelos serviços de saúde.
Islamic Economic Concepts To Form Community Welfare From The Perspective Of Ibnu Khaldun's Thinking
Authors: Nurcahyo Satria Avianda , Isnawati Setya Indah , Widagdo Teguh Harso , Rizal Achmad 
Published: August 2024

Purpose - This research aims to review Ibn Khaldun's thoughts regarding social welfare, Ibn Khaldun revealed that Allah outlined economic activities as an inseparable part of the social responsibilities that exist in society, and their incompleteness could threaten the continuity of world life and human existence.Method - This research is using a type of normative research, applying a library approach and a conceptual approach.Result - The result of this research indicates Ibnu Khaldun stated that Allah established muamalah activities as an integral form of responsibility in community life. Non-fulfillment can threaten world life and human welfare. In formulating three basic reasons for engaging in economic activity, Ibnu Khaldun explains that this is not only about fulfilling personal life needs. Ibnu Khaldun believes that the price of a good or service is influenced by the dynamic interaction between demand and supply. This concept highlights the interrelated relationship between the forces of demand and supply in determining the value of a product or service. Implication - This study It is hoped that there will be management and supervision of market prices by the state in the field, as suggested by Ibn Khaldun in his great work Muqadimmah.Originality - In the economic context, Ibnu Khaldun also highlighted the importance of government vigilance regarding the amount of money in circulation.
The Role of Redox Environment in Tumors
Authors: Wu Jiaping , Hu Liling , Liu Wei , Liu Xiaowen , Zheng Jun , Tan Xiao 
Published: August 2024

Abstract:
Reactive Oxygen Species (ROS) and the redoxin system regulate the redox
environment. Thus, they mediate various physiological and pathological processes involved
in tumor occurrence and development by activating redox-sensitive genes and
regulating redox signaling pathways, including tumor cell proliferation, migration, invasion,
and various cell death types. Therefore, the mechanism underlying redox environment
regulation must be clarified to accurately target this mechanism and improve the effect
of tumor treatment. This review introduces redox-sensitive transcription factors and
their activated downstream signaling pathways, and the application of inhibitors targeting
related transcription factors in tumor therapy.
Incorporation of Coffee and Stevia Leaf Powder in Making Gambir Leaf Tea
Authors: Lidiasari Eka , Sipahutar Ruth Elferawi , Rahmawati Laila , Priyanto Gatot , Defira Citra , Syaiful Friska , Syafutri Merynda Indriyani , Santoso Budi 
Published: August 2024

Background:
Gambier leaf tea contains antioxidant compounds, but its astringent taste
makes this tea less popular. The addition of coffee leaf powder and stevia not only reduces the astringent
taste of this tea but can also increase the content of antioxidant compounds.

Objective:
This research aimed to investigate the physical, chemical, functional, and organoleptic
properties of gambir leaf tea incorporated with coffee and stevia leaf powder.

Methods:
The investigation was carried out using a non-factorial, completely randomized design
with 5 treatments, each repeated 5 times. These treatments were developed based on different ratios
of gambir leaf formulations: coffee leaf powder:stevia leaf powder, namely F1= 100:0:0, F2=
95:1.5:3.5, F3= 90:3:7, F4= 85:4.5:10.5, and F5= 80:6:14.

Results:
The results indicated that gambir leaf tea has IC50 values, total phenols, pH, water content,
and ash content ranging from 36.57-54.25 ppm, 304.5-376 mgGAE/g, 5.46-5.68,
10.06-12.56%, and 2.06-2.61%, respectively.

Conclusion:
Gambir leaf tea incorporated with coffee and stevia leaf powder was found to contain
antioxidant compounds, while water and ash content fulfilled SNI standards. Organoleptically,
the color and aroma produced were well-received by the panelists.
PENGARUH PENDAYAGUNAAN DANA INFAQ LAZNAS LMI SURABAYA TERHADAP KESEJAHTERAAN MUNFIQ LAHU
Authors: Gunawan Echa Valentina , Muljaningsih Sri , M.Jaenudin  
Published: August 2024

This research discusses more deeply about infaq funds which one are one of the most donation posts in philanthropic institutions, especially the national amil zakat institution (Laznas). This study aims to analyze the effect of utilization, infaq funds on the welfare of munfiq lahu at Laznas LMI Surabaya area. This research uses a quantitative research method that refers to primary data, this study examines as many as 161 sample data using the Paired T-Test. Welfare theory in this research is translated into two variables, namely income variable and spiritual variable. The research findings show that the income variable affects the munfiq lahu’s welfare. The results of the study show that at Laznas LMI Surabaya area, the utilization of infaq funds distributed to munfiq lahu has an effect on income and spiritual variables with a note that internal parties Laznas LMI Surabaya area continue to provide assistance, montoring and periodic evaluation to munfiq lahu. This study shows that Laznas LMI Surabaya area is able to carry out to mandate from munfiq/donors to properly distribute infaq funds to munfiq lahu.

Keywords: Utilization; Infaq Fund; Munfiq Lahu Welfare; Philanthropy Institute
Studi Fenomenologi: Loyalitas Keikutsertaan Peserta PBPU BPJS Kesehatan di Kabupaten Bantul 2020
Authors: Ulum Dafiniatul , Fatimah Fatma Siti , Sumarni Sumarni 
Published: August 2024

<p align="center"> </p><p>BPJS Kesehatan merupakan program penyelenggaraan jaminan sosial di bidang Kesehatan. Kepesertaan BPJS adalah wajib bagi setiap warga negara Indonesia, PBPU (Pekerja Bukan Penerima Upah) adalah salah satu jenis peserta Non PBI yang iurannya dibayar secara mandiri oleh peserta BPJ Kesehatan, peserta jenis ini dianggap sebagai salah satu penyebab dari defisitnya BPJS, karena tidak disiplin dalam membayar iuran kepesertaan BPJS-nya dan menyebabkan perubahan tarif iuran BPJS Kesehata. Perubahan tarif iuran BPJS Kesehatan ini pun diramalkan akan membuat lebih banyak peserta PBPU yang berhenti membayar iuran BPJS-nya. Tujuan: Penelitian ini bertujuan untuk mengetahui gambaran loyalitas peserta PBPU BPJS terhadap keikutsertaan BPJS Kesehatan di Kabupaten Bantul tahun 2020. Metode Penelitian: Peneliti menggunakan metode deskriptif dengan pendekatan kualitatif. Pengambilan sampel menggunakan metode proposive sampling dengan Jumlah sampel 6 responden. Hasil Penelitian: Loyalitas Keikutsertaan peserta PBPU BPJS Kesehatan di Kabupaten Bantul cukup tinggi, dengan batasan ketika perubahan tarif iuran terjadi lagi dengan jumlah yang lebih tinggi maka peserta PBPU BPJS akan menyesuaikan kelas dengan kemampuan keuangan peserta seperti penurunan kelas dari kelas 2 ke kelas 3. Secara umum peserta puas dengan layanan BPJS Kesehatan, alasan responden mengikuti BPJS Kesehatan karena diwajibkan dan merasa membutuhkan atau perlu untuk mengikuti program BPJS Kesehatan, alas anresponden memilih menjadi peserta PBPU BPJS Kesehatan kelas 2 karena merasa mampu dan cukup berada di kelas 2, responden percaya terhadap pihak BPJS Kesehatan, rutin membayar iuran BPJS Kesehatan, dan akan terus mengikuti Program BPJS Kesehatan, Informasi-informasi seperti perubahan tarif iuran, perubahan kelas kepesertaan, sanksi bagi peserta yang tidak tertib membayar iuran, dan aplikasi Mobile JKN dari BPJS Kesehatan sudah tersampaikan dengan baik</p><p>kepada peserta BPJS Kesehatan. Kesimpulan: Loyalitas Keikutsertaan peserta PBPU BPJS Kesehatan di Kabupaten Bantul cukup tinggi, dengan batasan ketika perubahan tarif iuran terjadi lagi dengan jumlah yang lebih tinggi maka peserta PBPU BPJS akan menyesuaikan kelas dengan kemampuan keuangan peserta seperti penurunan kelas dari kelas 2 ke kelas 3.</p><p> </p><strong>Kata Kunci:</strong>Loyalitas; Pengalaman; Peserta PBPU; BPJS Kesehatan; Program BPJS Kesehatan<p align="center"> </p>
Sosialisasi Cegah Stunting dan Pemberian Makanan Tambahan (PMT) pada Balita di Desa Bojong, Kecamatan Mungkid, Kabupaten Magelang
Authors: Cahya Rahmawati Dwi , Rosnaeni Febriana , Safitri Safitri , Sandi Amalia , Zulyarti Zulyarti , Sukmaningtias Nanda , Soleha Maratus , Idayanti Idayanti , Titasari Ilma Silvia , Muqoddas Muhammad Faqih , Rafly M. , Pasha Aldi Hakim , Salim Ahmad 
Published: August 2024

<p><em>Stunting atau pendek merupakan suatu kondisi gagal tumbuh pada anak akibat kekuranan gizi kronis terutama dalam 1000 hari pertama kehidupan (HPK) sehingga anak terlalu pendek untuk usianya. Prevalensi stunting di indonesia sebanyak 21,6%. Target penurunan stunting di Indonesia ditetapkan sebesar 14% pada tahun 2024. Salah satu upaya penanggulangan stunting pada balita adalah dengan edukasi kepada masyarakat dalam rangka meningkatkan pengetahuan dan kesadaran akan pencegahan stunting, serta edukasi dalam pemberian makanan tambahan (PMT) dengan memanfaatkan bahan makanan berasal dari lokal, metode yang digunakan adalah ceamah dan tanya jawab antara peserta dan narasumber. Keberhasilan kegiatan sosialisasi terlihat dari antusiasme dari peserta yang turut hadir dalam kegiatan sosialisasi. Masyarakat di Desa Bojong aktif berpartisipasi dalan kegiatan yang dilakukan yang mana peserta melakukan feedback (diskusi tanya jawab) terkait dengan materi yang telah disampaikan oleh narasumber.</em></p><p align="left"><em> </em></p><p><strong><em>Kata kunci</em></strong><em>: Sosialisasi, Stunting, PMT</em></p>