bluuebunny/crossref_metadata_2025_split huggingface dataset:
Optical and electrical properties of Cu2O, Cu4O3 and CuO
Authors: Reppin Daniel , Polity Angelika , Meyer Bruno K. , Shokhovets Sviatoslav 
Published: January 2013

ABSTRACTWe deposited copper oxides by rf magnetron sputtering from a 4N Cu-target at room temperature, varying the oxygen flux and keeping the argon flow constant. Dependent on the oxygen flux Cu2O, Cu4O3or CuO were synthesized. The different compounds were characterized by XRD. The dielectric functions of the oxides were determined by spectroscopic ellipsometry and show significant differences between the compounds. The electrical properties, like the carrier concentration, of each compound can be tuned by adjusting the oxygen flux. We discuss the structural, optical and electrical properties of the copper oxides in terms of phase purity and stoichiometry deviations.
Influence of Psychosocial Factors and Habitual Behavior in Temporomandibular Disorder–Related Symptoms in a Working Population in Japan
Authors: Nishiyama Akira , Kino Koji , Sugisaki Masashi , Tsukagoshi Kaori 
Published: January 2013

Background:The symptoms of temporomandibular disorders (TMD) are directly influenced by numerous factors, and it is thought that additional factors exert indirect influences. However, the relationships between TMD-related symptoms (TRS) and these contributing factors are largely unknown. Thus, the goal of the present study was to investigate influences on TRS in a working population by determining the prevalence of TRS, analyzing contributing factors, and determining their relative influences on TRS.Materials and Methods:The study subjects were 2203 adults who worked for a single company. Subjects completed a questionnaire assessing TRS, psychosocial factors (stress, anxiety, depressed mood, and chronic fatigue), tooth-contacting habit, and sleep bruxism-related morning symptoms, using a 5-point numeric rating scale. Our analysis proceeded in 2 phases. First, all variables of the descriptor were divided into parts by using an exploratory factor analysis. Second, this factorial structure was verified by using a confirmatory factor analysis with structural equation modeling.Results:Of 2203 employees, 362 reported experiencing TRS (16.4%). Structural equation modeling generated a final model with a goodness of fit index of 0.991, an adjusted goodness of fit index of 0.984, and a root mean square error of approximately 0.021. These indices indicate a strong structural model. The standardized path coefficients for “habitual behavioral factors and TRS,” “psychosocial factors and habitual behavioral factors,” “psychosocial factors and TRS,” and “gender and habitual behavior factors” were 0.48, 0.38, 0.14, and 0.18, respectively.Conclusions:Habitual behavioral factors exert a stronger effect on TRS than do psychosocial factors.
Comparative analysis of the antibacterial activity of some phytolectins
Authors: Nair Sindhu Syama , Madembil Nithyakala Chandera , Nair Preetha , Raman Saraswathi , Veerabadrappa Somashekharaiah Beeranahalli 
Published: January 2013

The aim of this work was to analyse the comparative effects of the antibacterial properties of partially purified lectins from the seeds of Artocarpus heterophyllus (jack fruit), Canavalia ensiformis (jack bean), Lens culinaris (lentil) and Pisum sativum (pea) against the bacteria Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Pseudomonas aeruginosa. The lectins were isolated by partial purification using ammonium sulphate precipitation and dialysis. The antimicrobial activity was studied using agar well diffusion method. The results showed that the Jack fruit lectin had a potent anti-bacterial activity against S. aureus, B. subtilis, E. coli and P. aeruginosa whereas Pea and jack bean lectin were found to be effective bacteriostatic agents which reduced the growth of bacteria and lentil lectin showed the least antibacterial activity. A comparison of the antibacterial activity of phytolectins with conventional antibiotics namely ampicillin and tetracycline was also carried out. Studies revealed that the antibacterial activities of the conventional antibiotics are higher than that of the plant extracts at the same concentration in accordance to literature.DOI: http://dx.doi.org/10.3329/icpj.v2i2.13192 International Current Pharmaceutical Journal 2013, 2(2): 18-22
Evaluation of antinociceptive and antipyretic effect of Pupalia lappacea Juss
Authors: Neeharika Vajrala , Fatima Humaira , Reddy Bommineni Madhava 
Published: January 2013

Pupalia lappacea Juss (Family: Amaranthaceae) is claimed to be useful in treatment of bone fracture, wounds, boils, cough, toothache, fever and malaria. The study was aimed to evaluate the 80% aqueous ethanolic extract of aerial parts of P. lappacea for antinociceptive and antipyretic activities to verify the traditional claim. The extract was orally administered at doses of 200, 400 and 600 mg/kg. The extract has significantly (P<0.01) reduced the nociception induced by acetic acid. The effect produced was in dose dependent manner. The antinociceptive effect was not reversed by pretreatment with naloxone in acetic acid induced writhing test. In hot plate method, the extract has significantly increased the latency time of jump. The naloxone has partially antagonised the antinociception of extract in hot plate test indicating P. lappacea has morphinomimetic properties. In the study of the CNS-depressant effects, the extract was found to produce significant reduction in head pokes and locomotion in mice by using hole board and locomotor activity test respectively. The extract has significantly reduced the rectal temperature in yeast induced pyrexia in rats at 600 mg/kg. The activity produced by extract was in dose dependent manner. Phytochemical investigation of ethanolic extract of P. lappacea revealed the presence of steroids and/or triterpenoids, flavonoids and phenolic compounds which may be responsible for antinociceptive and antipyretic activity of P. lappacea.DOI: http://dx.doi.org/10.3329/icpj.v2i2.13193 International Current Pharmaceutical Journal 2013, 2(2): 23-28
Effectiveness of GABA agonist for treatment in mice with complete freuds adjuvants induced chronic pain: molecular modeling approach
Authors: Fajrin Fifteen Aprila 
Published: January 2013

The present study was designed to investigate the effectiveness of gaba agonist in behavioral changes of inflammatory mice with molecular docking approach. Forty mice were divided into 8 groups i.e. sham, gabapentin (10, 30 and 100 nmol), baclofen (1, 10 and 30 nmol) and negative control. Chronic pain was induced by inflammatory agent such as Complete Freuds Adjuvant (CFA). On day 8 after intraplantar injection of CFA, mice were treated by intrathecal with normal saline (sham and negative control groups), gabapentin and baclofen with three different doses, once a day for seven consecutive days. Latency time toward thermal stimulus was measured on days 1,2,8,9,11 and 15 after induction. The molecular docking was examined by Mollegro virtual docker program. The result showed that intrathecal injection of gabapentin and baclofen increased time latency toward thermal stimulus compared to negative control. There were differences between gabapentin and baclofen doses for chronic pain treatment. Molecular docking showed that the differences of effective dose were related to type of amino acid binding between gabapentin and baclofen.DOI: http://dx.doi.org/10.3329/icpj.v2i2.13194 International Current Pharmaceutical Journal 2013, 2(2): 29-32
Antioxidant and cytotoxic activities of Ageratum conyzoides stems
Authors: Nasrin Fatema 
Published: January 2013

Modern civilization is facing more than hundreds of disorders associated with free radicals and natural antioxidants from non-edible plants are gaining importance to fight these disorders. The intention of this report is to evaluate a well known medicinal weed Ageratum conyzoides stems for its antioxidant and cytotoxic Effects. Antioxidant potentiality of the crude methanolic extract of the Ageratum conyzoides (AC) stems was investigated on DPPH scavenging activity, reducing ability, total antioxidant capacity as well as total phenolic contents. Cytotoxic study was done by brine shrimp lethality bioassay and vincristin sulphate was used as standard. The total phenols and total antioxidant capacity of AC was found to be 38.125 ± 2.01mg/g equivalent of gallic acid and 333.37 ± 4.22mg/gm equivalent of ascorbic acid, respectively. The percentage (%) scavenging of DPPH free radical of the extract was found to be concentration dependent with IC50 value 46.01 ± 2.23µg/ml while IC50 value of standard ascorbic acid was found to be 29.56 ± 0.11?g/ml. The reducing power of AC was found to be concentration dependent. The cytotoxicity exhibited by AC was found promising with LC50 value 1.32?g/ml, comparing with the LC50 (0.689?g/ml) values of vincristin sulphate. The present investigation suggests that Ageratum conyzoides possesses remarkable antioxidant and cytotoxic property.DOI: http://dx.doi.org/10.3329/icpj.v2i2.13195 International Current Pharmaceutical Journal 2013, 2(2): 33-37
Evaluation of antioxidant activity and cytotoxic potential of Cryp-tocoryne ciliata
Authors: Nahar Ummey Jannatun , Lina Shah Marzia Mahjabin 
Published: January 2013

Cryptocoryne ciliata belonging to the Araceae family has been investigated for isolation of its secondary metabolites and evaluation of biological activities of the crude extractives with special emphasis to the antioxidant activity and brine shrimp lethality bioassay. The whole plant was extracted with methanol and concentrated extract was partitioned using petroleum ether, carbon tetrachloride and ethyl acetate. Aqueous soluble fraction of the methanolic extract showed the highest antioxidant activity. The carbon tetrachloride soluble fraction of the methanolic extract and the ethyl acetate soluble fraction of the methanolic extract showed moderate antioxidant activity as compared to free antioxidant activity of tert-butyl-1-hydroxytolunene. In the brine shrimp lethality bioassay, among all extracts of whole plant of C. ciliata, the carbon tetrachloride soluble fraction of the methanolic extract showed strong cytotoxic activity. Aqueous soluble fraction of the methanolic extract, methanolic crude and ethyl acetate soluble fraction of the methanolic extract showed mild cytotoxity as compared to that of vincristine sulphate. The study confirms the mild to moderate antioxidant and moderate potent cytotoxic activities of C. ciliata plant extract as compared to reference standards and therefore demands the isolation of active principles and thorough bioassay.DOI: http://dx.doi.org/10.3329/icpj.v2i2.13196 International Current Pharmaceutical Journal 2013, 2(2): 38-41
Les concours de pétanque du 14 Juillet à New York
Authors: Feschet Valérie 
Published: January 2013

Résumé Depuis une vingtaine d’années à New York, la fête du 14 Juillet s’accompagne de concours de pétanque. Organisés dans Manhattan et Brooklyn, ces concours très attendus témoignent du rapport nostalgique de la communauté française à certains motifs de la culture populaire qu’elle a perdus en s’installant aux États-Unis. Le pari de faire rentrer toute la « France de son enfance » dans un concours de boules reflète l’intensité des motivations sous-jacentes et permet de créer des liens nouveaux avec la Provence comme horizon.
Travailler avec et après W. R. Bion
Authors: Ferro Antonino 
Published: January 2013

Résumé Dans cet article l’auteur s’intéresse à ce qu’il appelle la « pathologie évacuatives » qui résulte de l’évacuation d’éléments psychiques d’origine sensorielle qui soit n’ont pas été mentalisés, soit ne l’ont été que partiellement. En s’appuyant sur la théorie de la pensée de W. R. Bion, il distingue la pathologie liée à la projection-évacuation d’éléments β purs, qui caractérise la pathologie psychosomatique, de celle où ce sont des dérivés narratifs qui sont projetés, comme dans la conversion hystérique. Ici le symptôme est porteur de sens, même s’il s’agit d’un sens élémentaire, là il est dépourvu de toute signification. La théorisation de W. R. Bion, ainsi que celle de W. et M. Baranger, centrée sur la notion de champ psychanalytique, ont déplacé l’axe du travail analytique de l’analyse des contenus psychiques vers celle des fonctions permettant la transformation des expériences sensorielles primaires en pictogrammes, puis en dérivés narratifs, à travers le travail du rêve, chez l’analyste comme chez le patient.
De quelques prisons d'infortune des « corps psychiques »
Authors: Fognini Mireille 
Published: January 2013

Résumé À partir d’une consultation clinique d’une fillette présentant une grave insomnie, il est évoqué comment sa projection identificatoire (identification projective) à la mère souffrant du même symptôme masqué par une chimiothérapie continue, empêche l’enfant d’habiter son corps psychique d’enfant, mais l’emprisonne dans la souffrance du corps psychique maternel bloquée elle-même dans une pathologie adaptative. Il est évoqué ensuite comment parfois la « partie enfant » chez certains adultes en analyse, peut rester tellement enclavée et inaccessible à la représentation émotionnelle intérieure, qu’ils peuvent recourir à la réalité d’une procréation, par laquelle l’enfant issu de leur corps et enfin visible hors d’eux, concrétiserait leur possible lien émotionnel d’enfance égaré voire encapsulé ou cristallisé quelque part en eux-mêmes.
« 53 jours » de Georges Perec : la génétique, mode d'emploi
Authors: Decout Maxime 
Published: January 2013

Résumé « 53 jours » , le dernier roman inachevé de Perec, se construit sur deux parties en miroir, la seconde partie défaisant la première. Perec propose ainsi à son lecteur de rechercher les principes dissimulés qui fondent le texte. Car « 53 jours » n’est pas seulement un roman policier, c’est aussi une enquête génétique dont de nombreux indices se trouvent dans des avant-textes. Mais, si les personnages d’herméneutes aident à déchiffrer le sens, ils affrontent sans cesse le risque de l’erreur. Le roman se dresse ainsi contre une génétique mythifiée où tous les sens de l’œuvre se programmeraient de façon intangible et absolue. Il propose un mode d’emploi lucide quant à une juste utilisation de la lecture génétique des œuvres.
Mise en œuvre opérationnelle d’un projet de compensation carbone de foyers améliorés au Niger
Authors: Joubert Fanny , Begovic Milena 
Published: January 2013

L’utilisation de foyers « ouverts » traditionnels utilisés au Niger a de lourdes conséquences au niveau environnemental, sanitaire et économique. Le projet de compensation carbone de foyers améliorés présenté ici consiste à remplacer ces foyers traditionnels par des foyers améliorés plus performants (appelés Kiva-Hybride) permettant de réduire la consommation de bois d'origine non renouvelable. La mise en œuvre d’un tel projet nécessite un travail préalable conséquent afin d’assurer sa pérennité sur le terrain : études statistiques, élaboration de différents prototypes de foyers avec tests de performance énergétique, réunions de consultations publiques avec les parties prenantes. Répondant à la méthodologie Gold Standard, ce projet permet non seulement de réduire les émissions de gaz à effet de serre à l’échelle mondiale, mais aussi d’améliorer les conditions de vie des populations locales (lutte contre la déforestation, amélioration de la qualité de l’air intérieur, économies des dépenses et de temps liés à la collecte du bois). En effet, le Kiva-Hybride permet de réduire les besoins en bois d’environ 1,5 tonne/foyer/an en moyenne conduisant à 2,79 teqCO2 d’émissions évitées par an et à l’économie de 47 500 FCFA/an par ménage.
Proteolysis Breaks Tolerance toward Intact α345(IV) Collagen, Eliciting Novel Anti–Glomerular Basement Membrane Autoantibodies Specific for α345NC1 Hexamers
Authors: Olaru Florina , Wang Xu-Ping , Luo Wentian , Ge Linna , Miner Jeffrey H. , Kleinau Sandra , Geiger Xochiquetzal J. , Wasiluk Andrew , Heidet Laurence , Kitching A. Richard , Borza Dorin-Bogdan 
Published: January 2013

Abstract
Goodpasture disease is an autoimmune kidney disease mediated by autoantibodies against noncollagenous domain 1 (NC1) monomers of α3(IV) collagen that bind to the glomerular basement membrane (GBM), usually causing rapidly progressive glomerulonephritis (GN). We identified a novel type of human IgG4-restricted anti–GBM autoantibodies associated with mild nonprogressive GN, which specifically targeted α345NC1 hexamers but not α3NC1 monomers. The mechanisms eliciting these anti–GBM autoantibodies were investigated in mouse models recapitulating this phenotype. Wild-type and FcγRIIB−/− mice immunized with autologous murine GBM NC1 hexamers produced mouse IgG1-restricted autoantibodies specific for α345NC1 hexamers, which bound to the GBM in vivo but did not cause GN. In these mice, intact collagen IV from murine GBM was not immunogenic. However, in Col4a3−/− Alport mice, both intact collagen IV and NC1 hexamers from murine GBM elicited IgG Abs specific for α345NC1 hexamers, which were not subclass restricted. As heterologous Ag in COL4A3-humanized mice, murine GBM NC1 hexamers elicited mouse IgG1, IgG2a, and IgG2b autoantibodies specific for α345NC1 hexamers and induced anti–GBM Ab GN. These findings indicate that tolerance toward autologous intact α345(IV) collagen is established in hosts expressing this Ag, even though autoreactive B cells specific for α345NC1 hexamers are not purged from their repertoire. Proteolysis selectively breaches this tolerance by generating autoimmunogenic α345NC1 hexamers. This provides a mechanism eliciting autoantibodies specific for α345NC1 hexamers, which are restricted to noninflammatory IgG subclasses and are nonnephritogenic. In Alport syndrome, lack of tolerance toward α345(IV) collagen promotes production of alloantibodies to α345NC1 hexamers, including proinflammatory IgG subclasses that mediate posttransplant anti–GBM nephritis.
Chlamydia pneumoniae Impairs the Innate Immune Response in Infected Epithelial Cells by Targeting TRAF3
Authors: Wolf Katerina , Fields Kenneth A. 
Published: January 2013

Abstract
Type I IFNs are induced during microbial infections and have well-characterized antiviral activities. TRAF3 is a signaling molecule crucial for type I IFN production and, therefore, represents a potential target for disarming immune responses. Chlamydia pneumoniae is a human pathogen that primarily infects respiratory epithelial cells; the onset of symptoms takes several weeks, and the course of infection is protracted. C. pneumoniae has also been associated with a variety of chronic inflammatory conditions. Thus, typical C. pneumoniae infections of humans are consistent with an impairment in inflammatory responses to the microorganism. We demonstrate that infection of epithelial cells with C. pneumoniae does not lead to IFN-β production. Instead, infected cells are prevented from activating IFN regulatory factor 3. This effect is mediated by C. pneumoniae–dependent degradation of TRAF3, which is independent of a functional proteasome. Hence, it is likely that C. pneumoniae expresses a unique protease targeting TRAF3-dependent immune effector mechanisms.
Metastasis to left scapula with unknown primary: Approach to pathological diagnosis
Authors: Vasenwala Shaista M , Ansari Hena A , Haider Nazima , Sabir Amir bin , Rehman Aseeb Ur 
Published: January 2013

AbstractBony metastasis is a frequent occurrence in malignancy. However, the clinical presentation and pathological findings may sometimes be more in favor of a primary bone lesion. In such cases, immunochemistry has a very important role to play in reaching a final diagnosis. We present the case of a 35 year male patient who was investigated for a lytic lesion in the left scapula and was finally diagnosed with metastatic adenocarcinoma with the help of immunostaining.
Computed tomogram guided fine-needle aspiration cytology of lung mass with histological correlation: A study in Eastern India
Authors: Mondal Santosh Kumar , Nag Dipanwita , Parikh Biren , Shah Manoj , Davara Kajal 
Published: January 2013

Abstract
Background: Fine-needle aspiration cytology (FNAC) is an important and useful investigation, and is considered next to imaging in the rapid diagnosis of pulmonary mass lesion for the last few decades. Aims: To assess the role of Computed Tomogram (CT) guided FNAC in pulmonary mass lesions; to analyze the results; and to compare with histopathological findings. Materials and Methods: The clinical, radiological, and cytological data of 130 patients were prospectively studied who underwent CT guided FNAC from October 2009 through September 2011. Thereafter these patients underwent bronchoscopic/trucut biopsy/ lobectomy, whatever clinically indicated. Smears and tissue sections were evaluated simultaneously to reach at a definite diagnosis. Results: Out of 130 cases, we found adequate FNAC smear and histopathology reports only in 124 cases. The age range varied from 35 to 73 years with the peak in the fifth to sixth decades. The benign lesions were 10 (8.07%) and malignant lesions were114 (91.93%) shown by cytology. The most common tumor was adenocarcinoma (51.72%) followed by squamous cell carcinoma (22.41%) and small cell carcinoma 6.89%. Diagnostic accuracy of CT guided FNAC was 95%. Post procedural complications such as hemorrhage and chest pain were minimal and were noted only in three cases. Conclusion: CT guided FNAC of pulmonary masses provides simple, easy, and reliable method for reaching rapid tissue diagnosis with minimal complication.
Pharmacoeconomic evaluation of rheumatoid arthritis treatment with selected biological drugs
Authors: Kowalik Krzysztof , Krysiński Jerzy , Białecka Urszula , Kolossa Katarzyna , Jeka Sławomir 
Published: January 2013

<b>Cel pracy: </b>Retrospektywne porównanie dwóch schematów leczenia reumatoidalnego zapalenia stawów (RZS) lekami biologicznymi: infli-ksymabem i etanerceptem, pod względem kosztów oraz skuteczności leczenia. <br />
<b>Materiał i metody</b>: Dane do analizy farmakoekonomicznej uzyskano z dokumentacji choroby 70 pacjentów leczonych na Oddziale Klinicznym Reumatologii i Układowych Chorób Tkanki Łącznej Szpitala Uniwersyteckiego nr 2 w Bydgoszczy. Retrospektywne badanie wykonano z perspektywy usługodawcy i uwzględniono tylko bezpośrednie koszty medyczne. Zastosowano analizę efektywności kosztów. Do oceny wyników leczenia wykorzystano różnicę wartości DAS28 przed rozpoczęciem leczenia i po 24 miesiącach stosowania leków lub po uzyskaniu remisji choroby. Zgodnie z Wytycznymi Dobrej Praktyki Farmakoekonomicznej wykonano analizę wrażliwości, sprawdzając wpływ zmian kluczowych parametrów na końcowy wynik analizy. <br />
<b>Wyniki:</b> Tańszym i bardziej skutecznym lekiem okazał się etanercept. Średni koszt leczenia jednego pacjenta etanerceptem oraz infliksymabem wynosi odpowiednio: 62 876,78 zł <i>vs</i> 66 361,03 zł. Po terapii etanerceptem u chorych zaobserwowano obniżenie wartości DAS28 o 3,38, natomiast po leczeniu infliksymabem wartość DAS28 zmniejszyła się do 3,11. Największy udział w kosztach całkowitych w obu schematach leczenia miały koszty leków biologicznych (97,3% dla etanerceptu i 86,02% dla infliksymabu). W terapii infliksymabem koszty hospitalizacji stanowiły 11,38% kosztów całkowitych. Koszt ten nie występował w przypadku terapii etanerceptem, ponieważ lek podawany jest ambulatoryjnie. Koszty badań diagnostycznych oraz koszty innych leków były wyższe w przypadku infliksymabu i wynosiły na jednego pacjenta odpowiednio 1365,63 zł i 293,63 zł, natomiast w przypadku etanerceptu odpowiednio 809,37 zł i 176,07 zł. Koszty badań lekarskich były wyższe w przypadku etanerceptu (713,00 zł dla etanerceptu i 69,19 zł dla infliksymabu) (tab. I i II). W jednokierunkowej analizie wrażliwości nie stwierdzono istotnych zmian w zakresie ± 10% podstawowej wartości kosztów (tab. III). <br />
<b>Wniosek:</b> Z farmakoekonomicznego punktu widzenia leczenie etanerceptem jest terapią dominującą, ponieważ jest tańsze i z klinicznego punktu widzenia skuteczniejsze.