bluuebunny/crossref_metadata_2025_split huggingface dataset:
Mixture of three amino acids as stabilizers replacing albumin in lyophilization of new third generation recombinant factor VIII GreenGene F
Authors: Paik Sang Hoon , Kim Yong Jae , Han Sang Kyul , Kim Jean Man , Huh Jae Wook , Park Young In 
Published: September 2012

AbstractA formulation with stabilizers replacing albumin was developed for lyophilization of recombinant factor VIII (FVIII), GreenGene F (WHO INN: beroctocog alfa), to achieve stability and eliminate safety issues of blood‐derived albumin. L‐Arginine (hydrophilic amino acid, positively charged side chain), L‐glutamic acid (hydrophilic amino acid, negatively charged side chain), and L‐isoleucine (hydrophobic amino acid, nonpolar) were selected as stabilizers, and the mixture of the three amino acids were optimized. The mixture had results comparative with albumin and other commonly used stabilizers showing good preservation of recombinant FVIII during lyophilization, robust stability with consistently high recovery of FVIIII, very low aggregate formation, and good storage stability without alterations in protein characteristics. In vivo test results showed that the efficacy was maintained and had no signs of toxicity. The study demonstrated that the three amino acid mixture acts as a good stabilizer for lyophilization of recombinant FVIII and as a safe excipient. © 2012 American Institute of Chemical Engineers Biotechnol. Prog., 2012
Identification of multiple subclones in peripheral T‐cell lymphoma, not otherwise specified with genomic aberrations
Authors: Yoshida Noriaki , Umino Akira , Liu Fang , Arita Kotaro , Karube Kennosuke , Tsuzuki Shinobu , Ohshima Koichi , Seto Masao 
Published: September 2012

AbstractPeripheral T‐cell lymphoma, not otherwise specified (PTCL, NOS) with genomic aberrations has been shown to resemble lymphoma‐type adult T‐cell leukemia/lymphoma (ATLL) in terms of its genomic aberration patterns, histopathology, and prognosis. We have shown recently that a majority of patients with acute‐type ATLL have multiple subclones that were likely produced in lymph nodes. In this study, we analyzed whether PTCL, NOS with genomic aberrations also has multiple subclones as found in ATLL by means of high‐resolution oligo‐array comparative genomic hybridization (CGH). Thirteen cases of PTCL, NOS were available for 44K high‐resolution array CGH analysis. The results showed that 11 (84.6%) of the 13 cases had a log2 ratio imbalance, suggesting that multiple subclones exist in PTCL, NOS with genomic aberrations. In order to analyze the association between multiple subclones and prognosis, we used previous bacterial‐artificial chromosome (BAC) array analyses for 29 cases and found that the existence of multiple subclones was associated with a poor prognosis (P = 0.0279).
Effectiveness of aromatase inhibitors and tamoxifen in reducing subsequent breast cancer
Authors: Haque Reina , Ahmed Syed A. , Fisher Alice , Avila Chantal C. , Shi Jiaxiao , Guo Amy , Craig Cheetham T. , Schottinger Joanne E. 
Published: September 2012

AbstractTamoxifen (TAM) has been prescribed for decades and aromatase inhibitors (AIs) have been used since the early 2000s in preventing subsequent breast cancer. However, outside of clinical trials, the effectiveness of AIs is not established. We examined the long‐term risk of subsequent breast cancer among survivors treated with TAM and AIs in a large health plan. The study included 22,850 survivors, diagnosed with initial breast cancer (stages 0–IV) from 1996 to 2006, and followed 13 years maximum. We compared the risk of subsequent breast cancer in those who used TAM and/or AIs versus nonusers (the reference group). Hazard ratios (HR) adjusted for patient, tumor, treatment, and health‐care characteristics were estimated using Cox models with time‐dependent drug use status. Women who used TAM/AIs had a large reduction in risk of subsequent breast cancer compared with nonusers. While confidence intervals (CI) for all hormone treatment groups overlapped, women with high adherence (medication possession ratio ≥80%) who used AIs exclusively and had positive ER or PR receptor status had the greatest risk reduction (HR = 0.34, 95% CI: 0.28–0.41), followed by those who switched from TAM to AIs (HR = 0.39, 95% CI: 0.30–0.49), and those who used TAM exclusively (HR = 0.42, 95% CI: 0.36–0.47). Women with high adherence had the greatest risk reduction in subsequent breast cancer, but the results were not substantially different from women who took the drugs less regularly. Compared with nonusers, the reduction in subsequent breast cancer risk ranged from 58% to 66% across the hormone treatment groups and degree of adherence.
Evaluation context's role in driving positive word‐of‐mouth intentions
Authors: Wien Anders Hauge , Olsen Svein Ottar 
Published: September 2012

ABSTRACTRelevant literature recognizes that transaction‐specific and cumulative evaluations are different, but few empirical studies test how these differences might affect the link between product evaluations and word of mouth (WOM). This study addresses this issue by assessing the simultaneous effects of perceived quality and satisfaction on the resulting positive WOM intentions for both types of evaluations. Results reveal that different factors drive positive WOM intentions depending on the context of the study. When the consumers' evaluations are related to a specific transaction, perceived quality is the dominating predictor of positive WOM intentions. When the evaluations are cumulative, satisfaction is the dominating predictor of positive WOM intentions. Copyright © 2012 John Wiley & Sons, Ltd.
Selling forensic psychiatry: Recruiting for the future, establishing services
Authors: Goethals Kris , Gunn John , Calcedo‐Barba Alfredo 
Published: September 2012

ABSTRACTBackground and AimThe Ghent Group – a group of European forensic psychiatrists – has discussed ways of informing fellow professionals and the wider public about their difficult and frequently misunderstood discipline, agreeing that the specialty may have to be ‘sold’ to those who pay for it and use it. Our aim was to consider the areas where this commonly occurs and the strengths and pitfalls of such promotion.DiscussionForensic psychiatrists need to be effective, accurate communicators. For court work, they need special training. High standards of work are the best selling technique. Outside court, the greatest challenge for forensic psychiatry is to reduce its stigma – it can easily be construed, wrongly, as excusing serious anti‐social behaviour. Special attention should be given to writing for a wider audience, not just the inner circle of practitioners. Electronic social media should also be deployed for this task. Those who provide funds for academic work should be specifically but differently targeted. They need to be persuaded of the scientific merit of the subject.EthicsTemptation to claim more for the discipline than can be justified have to be resisted. An English case that led to a miscarriage of justice illustrates this. The limitations of science here have to be understood. Philosophical questions relating to responsibility and culpability cannot be resolved by physical science alone. Misuse neuroimaging in court, for example, can lead to miscarriages of justice.ConclusionSelling forensic psychiatry to public and professionals is difficult but essential to counter anti‐forensic psychiatry movements that have emerged. The discipline needs to persuade others of its unique skills and embrace good science, compassion, public duty and ethical practice. It needs to treat with politicians and funders as well as the medical, psychological and legal professions. Copyright © 2012 John Wiley & Sons, Ltd.
Teaching forensic psychiatry in Europe
Authors: Nedopil Norbert , Gunn John , Thomson Lindsay 
Published: September 2012

ABSTRACTBackgroundForensic psychiatry was long regarded as sufficiently defined by the laws of a country to be restricted by national boundaries in all but a few areas. European Union (EU) employment rights and travel facilities have changed that within the EU.AimsThe goal of this research is to explore the role and development of a network of teachers and trainees in forensic psychiatry.Information and discussionEuropean Union countries differ widely in the extent to which they recognise forensic psychiatry as a specialty and thus also in the amount of training clinicians receive before they present themselves as expert witnesses in court, or develop or run services, or manage and treat individual offender patients. Nevertheless, a summer seminar for practicing clinicians, who also present evidence to court and for bodies considering discharge of potentially dangerous patients, has proved a useful forum for joint ‘European learning’. Participants have left with a sense of improved understanding of their own law and practices as well as new perspectives on what works for offenders with mental disorder. Copyright © 2012 John Wiley & Sons, Ltd.
Variations in Phosphorus Speciation in Response to Simulated Riparian Zone Enhancement with Red Mud to Treat Reclaimed Water
Authors: Qin Jing , Liu Ping , Wu Gang 
Published: September 2012

AbstractVariations in phosphorus speciation in two sets of simulated riparian zones with and without Perennial ryegrass were compared. Each set consisted of four units, each measuring 700 mm × 200 mm × 200 mm, which were enhanced with 0, 2.5, 5, and 7.5% red mud (RM) by weight. The levels of total phosphorus (TP), total dissolved phosphorus (TDP), soluble reactive phosphorus (SRP) in the effluent were analyzed, and phosphorus fractionation in the media were also determined after the systems had been operational for 3 months. The results showed that the unit received 2.5% RM had the highest rate of phosphorus removal, including TP, TDP, SRP, particulate phosphorus (PP), and dissolved organic phosphorus (DOP) were present at the average concentrations of 0.17, 0.10, 0.07, 0.08, and 0.03 mg/L in the effluent. Sequential phosphorus fractionation showed that calcium‐bound phosphorus (Ca–P) was the major component, indicating that the addition of RM induced aluminum/iron‐bound phosphorus (Al/Fe–P), which was intensely bioactive, to form intractable Ca–P, which further inhibited the release of phosphorus from the media. However, the presence of P. ryegrass had little effect on the removal of phosphorus. Therefore, RM, when used directly in riparian zones at a suitable concentration, is a novel and low cost additive material that can be used to remove phosphorus from reclaimed water.
Phosphoinositides and cytokinesis: The “PIP” of the iceberg
Authors: Echard Arnaud 
Published: September 2012

AbstractPhosphoinositides [Phosphatidylinositol (PtdIns), phosphatidylinositol 3‐monophosphate (PtdIns3P), phosphatidylinositol 4‐monophosphate (PtdIns4P), phosphatidylinositol 5‐monophosphate (PtdIns5P), phosphatidylinositol 3,4‐bisphosphate (PtdIns(3,4)P2), phosphatidylinositol 3,5‐bisphosphate (PtdIns(3,5)P2), phosphatidylinositol 4,5‐bisphosphate (PtdIns(4,5)P2), and phosphatidylinositol 3,4,5‐trisphosphate (PtdIns(3,4,5)P3)] are lowly abundant acidic lipids found at the cytosolic leaflet of the plasma membrane and intracellular membranes. Initially discovered as precursors of second messengers in signal transduction, phosphoinositides are now known to directly or indirectly control key cellular functions, such as cell polarity, cell migration, cell survival, cytoskeletal dynamics, and vesicular traffic. Phosphoinositides actually play a central role at the interface between membranes and cytoskeletons and contribute to the identity of the cellular compartments by recruiting specific proteins. Increasing evidence indicates that several phosphoinositides, particularly PtdIns(4,5)P2, are essential for cytokinesis, notably after furrow ingression. The present knowledge about the specific phosphoinositides and phosphoinositide modifying‐enzymes involved in cytokinesis will be first presented. The review of the current data will then show that furrow stability and cytokinesis abscission require that both phosphoinositide production and hydrolysis are regulated in space and time. Finally, I will further discuss recent mechanistic insights on how phosphoinositides regulate membrane trafficking and cytoskeletal remodeling for successful furrow ingression and intercellular bridge abscission. This will highlight unanticipated connections between cytokinesis and enzymes implicated in human diseases, such as the Lowe syndrome. © 2012 Wiley Periodicals, Inc
The role of nonlinear gradients in parallel imaging: A k‐space based analysis
Authors: Galiana Gigi , Stockmann Jason P. , Tam Leo , Peters Dana , Tagare Hemant , Constable R. Todd 
Published: September 2012

AbstractSequences that encode the spatial information of an object using nonlinear gradient fields are a new frontier in MRI, with potential to provide lower peripheral nerve stimulation, windowed fields of view, tailored spatially‐varying resolution, curved slices that mirror physiological geometry, and, most importantly, very fast parallel imaging with multichannel coils. The acceleration for multichannel images is generally explained by the fact that curvilinear gradient isocontours better complement the azimuthal spatial encoding provided by typical receiver arrays. However, the details of this complementarity have been more difficult to specify. We present a simple and intuitive framework for describing the mechanics of image formation with nonlinear gradients, and we use this framework to review some the main classes of nonlinear encoding schemes. © 2012 Wiley Periodicals, Inc. Concepts Magn Reson Part A 40A: 253–267, 2012.
Phosphate‐Based Organic Molecules Interleaved with Layered Double Hydroxide: Unraveling the Roles of Host Cations and the Guest‐Inhibiting Effect in Aluminum Corrosion Protection
Authors: Stimpfling Thomas , Leroux Fabrice , Hintze‐Bruening Horst 
Published: September 2012

AbstractThe incorporation of 2‐hydroxyethyl phosphate (2‐HEP) into layered double hydroxide (LDH) galleries results in the formation of new organic–inorganic hybrid assemblies, subsequently studied as a functionalized filler with regards to their corrosion inhibition as an epoxy‐based polymer primer coating of aluminum AA 2024. Hybrid layered assemblies as well as the concomitant conveivable processes that consist of the release of interleaved 2‐HEP and the uptake of corrosive Cl– anions were studied by X‐ray diffraction. From DC polarization experiments, it is demonstrated that the anodic corrosion inhibition of 2‐HEP is not impeded when the molecule is intercalated in the LDH container despite the absence of its release through anion exchange. Owing to the relatively low anticorrosive activity of 2‐HEP, the importance of the dissolution of the platelets over the course of the anodic corrosion process is uncovered in addition to the impact of the particles on barrier effects. In accordance with discussed anticorrosive mechanisms, the results reveal that the Mg2+‐based LDH host accelerates cathodic oxygen reduction, whereas the Zn2+‐based counterpart reduces anodic metal (or copper) dissolution. Additionally, through electrochemical impedance spectroscopy that probes the coating resistance after long immersion times, Zn2Al/2‐HEP hybrid LDH phase was found to perform as well as a chromate‐bearing LDH.
Synthesis and Structuring of Ni MoS2 by using an Ionic Liquid
Authors: Leyral Géraldine , Ribes Michel , Courthéoux Laurence , Uzio Denis , Pradel Annie 
Published: September 2012

AbstractTo minimize air pollution resulting from exhaust gas emission, a decrease in the concentrations of the sulfur compounds in fuels has become a major issue in the last 10 years. The development of catalysts for the hydrodesulfurization process is a challenge for the oil industry. In the present work, a new and easy way to synthesize Ni‐Mo‐S hydrotreatment catalysts and in particular the effect of ionic liquids on the final structure was studied. It was shown that the addition of the ionic liquid [BMIM][NTf2] to the main reactants [Ni(NO3)2·6H2O and (NH4)2MoS4] had a great impact on the final product morphology. Indeed, formation of nanoparticles instead of gel was observed, and the amount of ionic liquid introduced helped to control the shape and size of the particles. Moreover, it was also highlighted that the presence of an ionic liquid favored the promotion of MoS2 with Ni with an optimal Ni/(Ni+Mo) atomic ratio of 0.3, and it also impacted the nanostructure, leading to thinner and shorter MoS2 slabs, which are two attractive points for catalytic applications.
Organocatalyzed Intramolecular Michael Addition of Morita–Baylis–Hillman Adducts of β‐Arylnitroethylenes: An Entry to 3‐Aryl‐4‐nitrocyclohexanones
Authors: Raji Reddy Chada , Reddy Motatipally Damoder , Haribabu Kothapalli 
Published: September 2012

AbstractThe synthesis of 3‐aryl‐4‐nitrocyclohexanones has been achieved from the Morita–Baylis–Hillman adducts of β‐arylnitroethylenes. The strategy involves proline‐catalyzed diastereoselective intramolecular Michael addition to obtain 3,4‐trans‐disubstituted cyclohexanones. This method provides a facile access to (±)‐epibatidine analogues.
Discretionary and transactional human resource practices and employee outcomes: The role of perceived organizational support
Authors: Gavino Monica C. , Wayne Sandy J. , Erdogan Berrin 
Published: September 2012

AbstractUtilizing perceived organizational support (POS) as the mechanism linking HR practices to employee behaviors in the workplace, we examine a broad set of HR practices in order to understand the relative importance of each HR practice (i.e., those that explain incremental variance over other practices) in influencing employee behaviors. We differentiate between discretionary and transactional HR practices to test the discretionary investment requisite of POS theory. The results show that of the eight discretionary practices, only participation and decision making directly influenced the extra‐role behaviors that employees exhibit, and only training and development directly impacted the customer‐oriented behaviors. Furthermore, one of the transactional HR practices was found to have a direct effect on organizational citizenship behavior. Our findings indicate that the performance management process, promotional opportunities, participation, and involvement in decision making affect how employees behave toward the customer and the extra‐role behaviors they exhibit. Furthermore, this occurs through the view employees develop of the organization as a place to work. That is, these four HR practices demonstrate to employees that they are valued, and, in turn, this feeling of being appreciated impacts their commitment to delivering high‐quality service to the customer and going beyond their job responsibilities. Implications for research and practice are discussed. © 2012 Wiley Periodicals, Inc.
Performance implications of knowledge and competitive arousal in times of employee mobility: “The immutable law of the ex”
Authors: Pazzaglia Federica , Flynn Scott , Sonpar Karan 
Published: September 2012

AbstractThis article elaborates on extant literature on employee mobility by focusing on how the movement of personnel between competitors affects their competitive positions. Our mixed‐methods study of 402 head‐to‐head encounters from the English Premier League (2000–2005) reveals that transferred players improve the performance of the recipient team in head‐to‐head encounters against the donor. We also provide evidence that competitive arousal, as triggered by anger and pressures for proving loyalty to the recipient organization, as well as knowledge of the donor team's routines, explain the superior performance of transferred players. These results question the traditional view that organizational routines are not transferable through employee mobility. They also move beyond a prior emphasis on the negative effects of emotional states such as anger and competitive arousal, highlighting how these can occasionally be beneficial. © 2012 Wiley Periodicals, Inc.
Servant leadership, organizational identification, and work‐to‐family enrichment: The moderating role of work climate for sharing family concerns
Authors: Zhang Haina , Kwong Kwan Ho , Everett André M. , Jian Zhaoquan 
Published: September 2012

AbstractThe present study investigates the impact of servant leadership as perceived by followers on their work‐to‐family enrichment (WFE) by focusing on the mediating role of organizational identification and the moderating role of work climate for sharing family concerns. The results from a field survey of 230 married managers in China provide full support for our hypotheses, indicating that perceived servant leadership is positively related to WFE; this relationship is also mediated by organizational identification. In addition, work climate for sharing family concerns attenuates the effects of servant leadership on organizational identification and WFE. The theoretical and managerial implications of these findings are discussed. © 2012 Wiley Periodicals, Inc.
The social context of performance appraisal and appraisal reactions: A meta‐analysis
Authors: Pichler Shaun 
Published: September 2012

AbstractThis study reviews and meta‐analyzes the literature on the social context of performance appraisal. Results indicate that aspects of rater‐ratee relationship quality (i.e., supervisor satisfaction, supervisor support, supervisor trust) are strongly related to ratee reactions to performance appraisals. Rater‐ratee relationship quality is more strongly related to appraisal reactions than appraisal participation or performance ratings. Integrating social exchange theory with procedural justice theory, this article tested whether or not the relationship quality–appraisal reactions relationship was due to relationships between relationship quality and instrumental resources for the ratee (i.e., appraisal participation and rating favorability). When controlling for relationships between these resources and appraisal reactions, a direct path between relationship quality and reactions was significant, supporting a relational model of the exchange between appraisal partners. The relationship quality–appraisal reaction relationship was not moderated by performance rating favorability or appraisal participation. In total, these results highlight the importance of relationship quality to employee reactions to performance appraisal—and the importance of ratee reactions as an important resource in the social exchange between appraisal partners. Implications for theory, practice, and future research are discussed. © 2012 Wiley Periodicals, Inc.
A Comparative Analysis of Anglo‐Australian Pre‐packs: Can the Means Be Made to Justify the Ends?
Authors: Wellard Mark , Walton Peter 
Published: September 2012

AbstractWhereas pre‐packaged administrations have been prevalent in the UK for years, Australia's voluntary administration regime has been more restrictive of the practice. This article analyses the evolution of UK pre‐packs, why UK‐style pre‐packs are not prevalent in Australia and the challenges for UK and Australian lawmakers in striking the right balance with pre‐packs in their respective administration regimes. Building upon this analysis, the article proposes a mechanism that might make ‘connected‐party’ pre‐pack business sales work more fairly for stakeholders—that is, by obligating a connected‐party purchaser to make a future‐income contribution in favour of the insolvent company whose business has been ‘rescued’ by a pre‐packaged sale in administration. Copyright © 2012 INSOL International and John Wiley & Sons, Ltd.