bluuebunny/crossref_metadata_2025_split huggingface dataset:
Darstellung und Schwingungsspektren von Fluoro-Chloro-Osmaten(IV) einschließlich der Stereoisomeren/ Preparation and Vibrational Spectra of Fluoro-Chloro-Osmates(IV) Including Stereoisomers
Authors: Preetz W. , Ruf D. , Tensfeldt D. 
Published: February 2015

Abstract
The stepwise replacement of ligands in [OsCl6]2- by oxidation with BrF3 generates the mixed complexes [OsFnCl6-n]2-, n = 1 - 5, of which the species with n = 2,3,4 are cw-configurated. Due to the stronger trans-effect of Cl compared to F on treatment of [OsF5Cl]2- and cis-[OsF4Cl2]2- with Cl- the trans-isomers are formed stereospecifically. The pure fluoro-chloro-osmates(IV) are separated by ion exchange chromatography on diethylaminoethylcellulose. From the pairs of stereoisomers the cis-compounds are always first eluted, whereas the trans-complexes are moving faster in an electric field by 3 to 5% . The vibrational spectra of octahedral mixed ligand complexes are generally discussed according to point groups Oh, D4h, C4v, C3v and C2v. For the fluoro-chloroosmates(IV) all stretching and deformation bands are assigned. They are observed in the characteristic regions; ν(OsF): 625-490 > ν(OsCl): 360-300 > δ (FOsF): 275-210 > δ (FOsCl) > δ (ClOsCl): 190-150 > νL: < 100 cm -1.
ReNF4 · ReF5(NCl), ein Nitrido-Nitrenokomplex von Rhenium(VII)/ ReNF4 · ReF5(NCl), a Nitrido Nitrene Complex of Rhenium (VII)
Authors: Kafitz Willi , Dehnicke Kurt , Schweda Eberhard , Strähle Joachim 
Published: February 2015

Abstract
ReNF4 · ReF5(NCl) is prepared by direct fluorination of ReNCl4 with fluorine between 80 °C and 130 °C. The red crystals are extremely sensitive to moisture. The complex is characterized by the IR spectrum and by an X-ray structural investigation. ReNF4 · ReF5(NCl) crystallizes orthorhombically in the space group Pnma with 4 formula units per unit cell and with the cell dimensions a = 1440, b = 848, c = 776 pm (419 observed, independent reflexions, R = 13.9%). The complex consists of the molecules ReNF4 and ReF5(NCl), which are linked by a linear asymmetric fluorine bridge. The bridging fluorine atom is in trans-position to the nitrido ligand Re -F - 228 pm) and to the nitreno ligand (Re -F = 159 pm and Re= N - Cl 164 pm) correspond to triple 188 pm). The Re ≡ N bond lengths Re= N bonds.
Strukturverfeinerungen an den Cobalt(II)hexammin-Komplexen [Co(NH3)6](BF4)2 und [Co(NH3)6](PF6)2/ Structure Refinements of the Cobalt(II)hexammine Complexes [Co(NH3)6](BF4)2 and [Co(NH3)6](PF6)2
Authors: Kummer S. , Babel D. 
Published: February 2015

Abstract
Using single crystal X-ray data of the compounds [Co(NH3)6](BF4)2 (a = 1129.8(1) pm) and [Co(NH3)6](PF6)2 (a = 1195.9(1) pm) the anti-K2PtCl6 structure, space group Fm3m , was confirmed for both complexes (R ≈ 0.05). Fourier methods revealed essential disorder for the BF4
- anion only, the fluorine atoms of which remain concentrated, however, within the octants of the subcell opposite to the cobalt atoms. No indication of H bridging is found in the IR spectra. The Co-N bond lengths of 218.3(2) and 218.7(10) pm, resp.. in the cobalt(II)hexammine group are unusual long in both compounds.
31P-NMR-spektroskopische Untersuchungen an A4B3-Molekülen/ 31P NMR Spectroscopical Investigations of A4B3 Molecules
Authors: Blachnik R. , Wickelund U . , Schmitt P. 
Published: February 2015

Abstract

31P NMR data of sixteen molecules in the series P4SxSe3-x (x = 0 - 3), PyAs4-yS3, and PyAs4-ySe3 (y = 0 - 4), resp., are given. All molecules have a common structure, in which a basal ring of three V b-atom s is connected by three chalcogen atom bridges to an apical V b-atom . The dependence of the data on bond angles and electronegativities is discussed. A linear relationship was found betw een chemical shift and an angle increment I=11.3 (∢ endo - 60°) + 5.5 (∢ exo -103°), which describes the bond angle deviations from the reference molecule P4S3.
Synthese und Kristallstruktur von Tris(2,2'-bipyridin)eisen(II) μOxo-bis(trichloroeisen(III)), ein Salz mit dem Anion Fe2OCl6
2-
Authors: Weiss Herbert , Strähle Joachim 
Published: February 2015

Abstract
[Fe(2,2'-bpy)3][Fe2OCl6] is obtained in form of red, air stable crystals by oxidation of Fe(bpy)Cl2 with O2 in acetonitrile. It crystallizes in the monoclinic space group P21/c with Z = 4. The crystal structure contains Fe(bpy)3
2+ and Fe2OCl6
2- ions. The anion exhibits a bent oxobridge with Fe-O-Fe = 148,1° and Fe-O distances of equal length (176,5 pm). In the IR spectrum νas Fe-O-Fe is observed at 850 cm-1, the Fe-Cl valence vibrations at 362 and 317 cm -1.
Darstellung, 11B-NMR- und Schwingungsspektren der oktaedrischen closo-Boratanionen B6X6
2-; X = H, Cl, Br, I
Authors: Preetz W. , Fritze J. 
Published: February 2015

Abstract
On treatment of Na2B6H6 with halogens in aqueous alkaline solution, the hexahalogenoborates B6X6
2-, X = Cl, Br, I, are formed. Their octahedral structure is proved by 11B NMR spectroscopy. The chemical shifts in relation to BF3 · OEt2 increase within the series H (-13.5) < Cl (-17.4) < Br (-18.5) < I (- 27.5 ppm ). The IR and Raman spectra are assigned according to point group Oh. The internal vibrations of the B6-cage, observed in the range 750-1250 cm-1 at nearly unchanged positions, are distinguishable from vibrations mainly originating from motions of the X6-shell against the rigid B6-cluster.
Phthalocyanine von Cobalt(III): Darstellung, Resonanz-Raman-, Infrarot- und elektronische Absorptionsspektren von [CoX2Pc(1—)] (X = Cl, Br) and [CoX2Pc(2-)]- (X = OH, F, CI, Br)
Authors: Homborg H. , Kalz W. 
Published: February 2015

Abstract
The preparation of anionic phthalocyaninato-cobaltates(III) [CoX2Pc(2-)]- (X = OH . F, CI, Br) is described. The UV -VIS. IR and Resonance-R am an (RR ) spectra are measured and com pared with those of the complexes [CoX2Pc(1 -)] (X = Cl, Br) containing the phthalocyanine-π-cation- radical.The characteristic spectroscopical differences for the Pc(1-)- and Pc(2-)-Ligands are discussed. Besides the typical B-, Q- and N-transitions of the Pc(1 -)- and Pc(2 -)-ligand additional weak bands are observed in the UV -VIS spectra for both dichloro- and dibromocomplexes. These bands are assigned to X (π , σ) → Co electron transfer a2u(πx), a2u(σx) → a1g(d); for the Pc(1 - )-complexes Cl(π) is at 22.9, Cl(σ) at 38.9. Br(π-) at 19.6 and Br(σ) at 36.4 kK. For the Pc(2-)-complexes these bands are slightly red-shifted by about 0.5 kK. The assignment is confirm ed by the RR-spectra. For both dichloro- and dibromo-complexes the sym. (Co-X)- stretching vibration (a1g, ν1) is strongly RR-enhanced and up to four overtones of ν1 are observed (for Pc(2-): ν ( Co - X ) for X = Cl: 270. Br: 165 cm-1; for Pc ( 1 - ) : X = Cl: 280. Br: 168 cm-1). The antisym. (Co -X)-stretching vibration (a2u) is observed in the FIR spectra (for Pc(2 -): ν(Co-X) for X = F: 546. Cl: 333. Br: 243 cm-1; for Pc ( 1 - ) : X = Cl: 326. Br: 250 cm-1).
Iridiumkomplexe des Vaska-Typs mit Triisopropylphosphan-Liganden [1]
Authors: Werner H. , Höhn A. 
Published: February 2015

Abstract
The complexes trans-[IrClL(PiPr3)2] (L = CO , py, CH3CN) were prepared from [(C8H14)2lrCl]2 via[IrCl(PiPr3)2] as intermediate. rrans-[IrCl(CO)(PiPr3)2] reacts with LiC2Ph to form trans- [IrC2Ph(CO)(PiPr3)2] which on treatment with HX produces [IrH X(C2Ph)(CO)(PiPr3)2] (X = Cl, CF3CO2). The trifluoroacetate ligand is displaced by iodide to give [IrHI(C2Ph)(CO)(PiPr3)2]. trans-[IrCl(N2)(PiPr3)2] is obtained from the carbonyl complex and 2-furfurylazide.
Darstellung und Eigenschaften der tert-Butyliminovanadium(V)-Verbindungen tC4H9N =VX3 (X = Br, OR)
Authors: Preuss Fritz , Towae Willi , Kruppa Volker , Fuchslocher Edith 
Published: February 2015

Abstract

tC4H9N = VBr3 has been prepared by reaction of the trichloride with hydrogen bromide dissolved in benzene. The structure of the 2.2'-dipyridyl complex [tC4H9N = VBr3 · C10H8N2] has been found to be octahedral with meridional arrangement of bromide. Syntheses of iC3H7N = V(OR)3 and iC3H7N = V(OR)3 are described. The properties of these compounds are studied by chemical reactions such as redistribution, transamination and alcoholysis. The 51V NM R spectra of the alkyliminovanadium(V) compounds are discussed; the constants of 51V , 14N coupling have been determined. The oxovanadium (V) complex [VO (OCH3)3-V O(OCH3)2Cl] has been prepared; all attempts to prepare VO(OCH3)2Cl have not been successful.
Funktionelle Trimethylphosphanderivate, XXII [1] Struktur und Reaktivität von Lithium-tris(dimethylphosphino)methanid sowie Molekülstruktur von / Functional Trimethylphosphine Derivatives, X X II [1]
Structure and Reactivity of Lithium-tris(dimethylphosphino)methanide
and Molecular Structure of
Authors: Karsc Hans Heinz , Weber Lothar , Wewers Dietmar , Boese Roland , Müller Gerhard 
Published: February 2015

Abstract
The reaction of Lithium-tris(dimethylphosphino)methanide with methyl iodide is sensitive to the choice of the solvent and reaction conditions; in pentane at room temperature and in the presence of tetramethylethylenediamine, Me3P = C(PMe2)2 is the major product, whereas in tetrahydrofuran, (Me2P)3C -CH3 is formed predominantly. Under similar conditions, Lithium-bis- (dimethylphosphino)methanide reacts with Mel to give (Me2P)2C(CH3)H as the main product. An X-ray structure determination of the tetrahydrofuran solvate of LiC(PMe2)3 reveals this compound to be dimeric with one solvent molecule coordinating to Li. A pseudo tetrahedral coordination sphere around each Li atom is completed by two phosphino groups of one [C(PMe2)3]- anion and a contact ion pair interaction with the carbanionoid center of the second. The crystals are monoclinic, space group P21/n, with a = 928.5(2), b = 1250.8(3), c = 1407.9(3) pm, β = 100.07(1)°, V = 1609.9 • 106 pm3 Dc = 1.13 g/cm3 for Z - 4 at -40 °C. Full-matrix least-squares refinement of 249 parameters based on 2158 reflections converged at R = 0.029. The ligand properties of (Me2P)3CCH3 are tested in its reactions with (CO)4Cr(C7H8) and (CO)5Cr[CH2S(O)Me2] from which

and

may be isolated. The latter crystallizes in the monoclinic space group P21/c with a - 1218.5(3). b = 881.7(3), c = 1824.1(4) pm, β = 106.66(2)°, V = 1877.6(9) • 106 pm3, Dc = 1.37 g/cm3 for Z = 4. Least-squares refinement of 218 parameters on 1615 reflections produced R = 0.063. The structure determination confirms the molecule to contain a five-membered

heterocycle in an approximate envelope conformation.
Ligand Exchange in FAB Mass Spectrometry of Monomerie and Dimeric Corrinoids
Authors: Grotjahn Lutz , Ernst Ludger 
Published: February 2015

Abstract
In the Fast Atom Bombardment (FAB) mass spectra of monomeric and dimeric corrinoids, exchange of metal-bound ligands against matrix particles is observed which leads to pseudo molecular ions. Negative ion FAB mass spectra in particular, give distinct information on the intact molecular units.
Zweikernige Bis(dimethylphosphino)ethan-Nickel(0)-Komplexe (dmpe)1+nNi2(C2H4)4-n (n = 0, 1, 2) und (dmpe)4Ni2
Authors: Pörschke Klaus R. , Mynott Richard 
Published: February 2015

Abstract
Reaction of tris(ethene)nickel(0) with dmpe at low temperature affords the crystalline compounds (dmpe)Ni2(C2H4)4 (6), (dmpe)2Ni2(C2H4)3 (7), and (dmpe)3Ni2(C2H4)2 (8), depending on the stoichiometries employed. In 7 and 8 , nickel is tetrahedrally coordinated by ethene and three phosphorus ligands. In addition, (dmpe)4Ni2 (9) has been obtained with excess dmpe at 20 °C. Structural assignments were made on the basis of NMR spectra.
Diastereomere Organophosphorverbindungen, I Darstellung und Eigenschaften von CH3(t-C4H9)P(X)—Y —(Z)P(t-C4H9)CH3
Authors: Hägele Gerhard , Tossing Gudrun , Kückelhaus Wolfgang , Seega Jürgen 
Published: February 2015

Abstract
Diastereomeric mixtures for members of series CH3 (t-C4H9)P(X ) -Y -(Z)P(t-C4 H9)CH3 were prepared. Pure meso- and rac-[CH3 (t-C4H9)P (S)]2 (8a/8b) and rac-[CH3 (t-C4H9)P(S)]2S (13) were isolated. Exchange reactions leading to redistribution of sulfur between tri- and pentavalent phosphorus sites are discussed. A novel one-batch method is used for the synthesis of diphosphine disulfides.
A Convenient Method for the Synthesis of Sterically Hindered Aryl Isocyanates
Authors: Habib Nargues S. , Rieker Anton 
Published: February 2015

Abstract
Reaction of a sterically hindered aniline with a sterically non-hindered arylisocyanate produces the sterically hindered aryl isocyanate in good yields besides the urea derived from the unhindered aryl isocyanate.
Derivate des 1.3-Benzdioxols, 53 [1] Darstellung von N-Alkyl-2-aryl-pyrrolidinen
Authors: Dallacker Franz , Jouck Walter 
Published: February 2015

Abstract
The conversion of the metal organyls of 1,3-benzdioxole, pyrido[2.3-d]-1.3-dioxole and pyrido[2.3-b]-1.4-dioxene using lactimethers did not prove successful. The N-alkyl-2-aryl-pyrrolidines 10a-c, 11a-c, 12a, 13a and 14a were synthesized from the aldehydes 4a-c via the γ-ketonitriles 7a-c and the 2-aryl-⊿1-pyrrolidines 8 a-c; in some cases, the recovery was high.
Ein Beitrag zur photoinduzierten Umwandlung des Atebrins®
Authors: Mansour M. , Thaller S. , Parlar H. , Körte F. 
Published: February 2015

Abstract
The hydrochloride of 2-methoxy-6-chloro-9-[(δ- diethylamino-α-methyl-butyl)amino]-acridine (Atebrine®) (1) reacts under the influence of UV light (λ > 290 nm) in water via N -C-clearage intermolecular to 2-methoxy-6-chloro-9-am ino-acridine (2) and 2-methoxy-6-chloro-acridine (3). Their formation is directly depend of water and partial pressure of oxygen. The reaction is controlled probably by reactive oxygen species (1O2, ·OH and ·OOH), which can be formed in an energy or electron transfer process between singlet-excited Atebrine® (1) and water/oxygen mixture.
Dinitrosylvanadiumkomplexe: [VL4(NO)2]Br (L = N, P, As, Sb, O und S-Donor/Akzeptor) und [VX(CNR)3(NO)2] (X = Cl, Br, I) / Dinitrosylvanadium Complexes: [VL4(NO)2]Br (L = N, P, As, Sb, O and S Donor/Acceptor) and [VX(CNR)3(NO)2] (X = Cl, Br, I)
Authors: Näumann Fritz , Rehder Dieter 
Published: February 2015

The reaction between [V(THF)4(NO)2]Br and various ligands {L} with a N , P. As, Sb, O and S donor/acceptor function leads to the complexes [V(THF)4-n{L}n(NO)i]Br, where n = 4 [P(OMe)3, Me2P(CH2)2PMe2, {N }, {O }, {S}], n = 2 and 3 [{P}, AsEt3, SbEt3], and n = 1 [P(OMe)3, AsEt3, SbEt3, Ph2P (CH2)3PPh2, Ph2As(CH2)2PPh2]. The constitution of the compounds is established on the basis of 51V NMR characteristics [(δ(51V) and 1J(51V -31P)]. The two NO groups occupy cis positions (IR evidence). With isonitriles, [V(THF)4(NO)2]X yields the neutral complexes [VX(CNR)3(NO)2] as the main products, which exhibit a normal halogen dependence (X = Cl < Br < I) of 51V shielding.
δ(51V ) values span a range from +296 (L = THF) to -1100 ppm [½ L = Me2P(CH2)2PMe2] relative to VOCl3. Shielding of the 51V nucleus decreases in the order PR3 ≈ CNR > {N } > {S} > {O }; en > dipy. phen > diazadiene > NCR > py > NH2Ph; OPR3 > OSMe2 > OCR2 > THF; and PMe3 > SbEt3 ≈ AsEt3 ≈ -PPh2 > - AsPh2. This ordering reflects (counteracting) trends in the polarizability and the π acceptor ability of the ligands. An effect caused by the chelate ring size (5-ring > 6-ring > 4-ring) is also observed and reflects torsional and ring strains.
Cyclo-thiazenokomplexe von Vanadium(V) Die Kristallstruktur von (AsPh4)2[V(N3)3(N3S2)]2 · CH2Cl2 / Cyclo-thiazeno Complexes of Vanadium(V) The Crystal Structure of (AsPh4)2[V(N3)3(N3S2)]2 · CH2Cl2
Authors: Hanich Jürgen , Krestel Magda , Müller Ulrich , Dehnicke Kurt , Rehder Dieter 
Published: February 2015

An improved synthesis for [VCl2(N3S2)]∞, was found in the reaction of VOCl3 with (NSCl)3; when the reaction is performed in H2CCl2 and (NSCl)3 is used in excess, the thiazyl-solvate [VCl2(N3S2) · NSCl]2 is obtained. [VCl2(N3S2)] reacts with AsPh4Cl to form (AsPh4)2[VCl3(N 3S2)]2; this reacts with AgN3 in CH2Cl2 suspension to yield (AsPh4)2[V (N3)3(N3S2)]2 · CH2Cl2. The compounds were characterized by their IR and 51V NMR spectra. The latter are compared with new 51V NMR data for [VO2Cl2]⊖ and [VOCl4]⊖ ; a decrease of 51V shielding in the order [VO2Cl2]⊖ > [VOCl4]⊖ > [VX3(N3S2)]2
2⊖ (X - N3 > Cl) is found, which is interpreted in terms of increasing polarizability of the ligands and of ring contributions to the extreme deshielding observed with the thiazenovanadates.
The crystal structure of (AsPh4)2[V(N3)3(N3S2)]2 · CH2Cl2 was determined from X-ray diffraction data (1496 observed reflexions, R = 0.058). It crystallizes in the triclinic space group P 1̄ with one formula unit per unit cell and with the lattice constants a - 1087, b = 1317, c = 1350 pm, α = 58.8, β = 85.9, γ = 68.0°. The structure consists of AsPh4
⊕ ions, CH2Cl2 molecules and centrosymmetric [V(N3)3(N3S2)]2
2⊖ anions. In the latter. N3S2 ligands are bonded to the V atoms in a chelate manner with short V = N bonds (189 and 172 pm) forming planar VN3S2 rings. The dimerization is accomplished by V -N donor-acceptor interactions (224 pm) involving one N atom of each VN3S2 ring. The vanadium coordination number of 6 is com pleted by three azido groups with V -N bond distances of 200 to 204 pm.
Neue ternäre intermetallische Phasen von Kalium und Rubidium mit 8b- und 5b-Elementen / New Ternary Intermetallic Phases of Potassium and Rubidium with 8b- and 5b -Elements
Authors: Wenz Peter , Schuster Hans-Uwe 
Published: February 2015

New ternary compounds of the formula A2BX2 in the orthorhombical K2PdP2-structure, space group Cmcm, have been prepared from the elements potassium, rubidium (A -element), nickel, palladium, platinum (B -element) and phosphorus or arsenic (X -element). They are isotypic with K2PdAs2, K2PdP2 and K2PtAs2 and are characterized by BX2-zig-zag-ribbons surrounded by channel-like arranged alkali atoms.
Another group of ternary com pounds with the formula AB2X2 (A = K, Rb; B = Fe, Co, Ru, Rh, Ir; X = P, As) is isotypic with KFe2As2, KCo2As1, KRh2As2, KRh2P2, ThCr2Si2-type structure (space group I4/mmm).
Break–apart interphase fluorescence in situ hybridization assay in papillary thyroid carcinoma: on the road to optimizing the cut-off level for RET/PTC rearrangements
Authors: Colato Chiara , Vicentini Caterina , Cantara Silvia , Pedron Serena , Brazzarola Paolo , Marchetti Ivo , Di Coscio Giancarlo , Chilosi Marco , Brunelli Matteo , Pacini Furio , Ferdeghini Marco 
Published: February 2015

ObjectiveChromosomal rearrangements of theRETproto-oncogene is one of the most common molecular events in papillary thyroid carcinoma (PTC). However, their pathogenic role and clinical significance are still debated. This study aimed to investigate the prevalence of RET/PTC rearrangement in a cohort ofBRAFWT PTCs by fluorescencein situhybridization (FISH) and to search a reliable cut-off level in order to distinguish clonal or non-clonal RET changes.DesignFortyBRAFWT PTCs were analyzed by FISH for RET rearrangements. As controls, sixBRAFV600E mutated PTCs, 13 follicular adenomas (FA), and ten normal thyroid parenchyma were also analyzed.MethodsWe performed FISH analysis on formalin-fixed, paraffin-embedded tissue using a commercially available RET break–apart probe. A cut-off level equivalent to 10.2% of aberrant cells was accepted as significant. To validate FISH results, we analyzed the study cohort by qRT-PCR.ResultsSplit RET signals above the cut-off level were observed in 25% (10/40) of PTCs, harboring a percentage of positive cells ranging from 12 to 50%, and in one spontaneous FA (1/13, 7.7%). Overall, the data obtained by FISH matched well with qRT-PCR results. Challenging findings were observed in five cases showing a frequency of rearrangement very close to the cut-off.ConclusionsFISH approach represents a powerful tool to estimate the ratio between broken and non-broken RET tumor cells. Establishing a precise FISH cut-off may be useful in the interpretation of the presence of RET rearrangement, primarily when this strategy is used for cytological evaluation or for targeted therapy.
A Novel Approach for Identifying Causal Models of Complex Diseases from Family Data
Authors: Park Leeyoung , Kim Ju H 
Published: February 2015

Abstract
Causal models including genetic factors are important for understanding the presentation mechanisms of complex diseases. Familial aggregation and segregation analyses based on polygenic threshold models have been the primary approach to fitting genetic models to the family data of complex diseases. In the current study, an advanced approach to obtaining appropriate causal models for complex diseases based on the sufficient component cause (SCC) model involving combinations of traditional genetics principles was proposed. The probabilities for the entire population, i.e., normal–normal, normal–disease, and disease–disease, were considered for each model for the appropriate handling of common complex diseases. The causal model in the current study included the genetic effects from single genes involving epistasis, complementary gene interactions, gene–environment interactions, and environmental effects. Bayesian inference using a Markov chain Monte Carlo algorithm (MCMC) was used to assess of the proportions of each component for a given population lifetime incidence. This approach is flexible, allowing both common and rare variants within a gene and across multiple genes. An application to schizophrenia data confirmed the complexity of the causal factors. An analysis of diabetes data demonstrated that environmental factors and gene–environment interactions are the main causal factors for type II diabetes. The proposed method is effective and useful for identifying causal models, which can accelerate the development of efficient strategies for identifying causal factors of complex diseases.
Beyond Asexual Development: Modifications in the Gene Expression Profile Caused by the Absence of the Aspergillus nidulans Transcription Factor FlbB
Authors: Oiartzabal-Arano Elixabet , Garzia Aitor , Gorostidi Ana , Ugalde Unai , Espeso Eduardo A , Etxebeste Oier 
Published: February 2015

Abstract
In the model fungus Aspergillus nidulans, asexual development is induced from vegetative hyphae by a set of early regulators including the bZIP-type transcription factor FlbB. To determine the range of genes under the influence of the transcriptional activity of FlbB and to characterize their role in fungal development, we sequenced and compared the transcriptomes of a ΔflbB mutant and its isogenic wild-type strain at different developmental stages. Results confirmed the activating role of FlbB on downstream regulators of conidiation such as flbD and brlA. However, FlbB has additional functions beyond the induction of asexual development. Among the changes observed, absence of a functional FlbB caused induction of the dba cluster and synthesis of a secondary metabolite with bactericidal properties. In addition, a new transcriptional target of FlbB was unveiled, urdA, that codes for a putative transcription factor that represses premature sexual development. Taken together, our results indicate that the activators of asexual development simultaneously exert a role on other cellular functions, including an inhibitory effect on the sexual cycle, and reinforce the hypothesis that mutually exclusive metabolic and cellular patterns are associated with different morphogenetic programs.