bluuebunny/crossref_metadata_2025_split huggingface dataset:
Occurrence of Milnacipran-Associated Morbilliform Rash and Serotonin Toxicity
Authors: Huskey Amanda M , Thomas Cassandra C , Waddell James Aubrey 
Published: July 2013

OBJECTIVE To report the development of morbilliform rash and serotonin toxicity after the addition of milnacipran to a patient's medication therapy. CASE SUMMARY A 57-year-old white female presented to the emergency department because of a full-body morbilliform rash, which appeared 9 days after initiation of milnacipran 50 mg twice daily. In the emergency department the patient's vital signs were: heart rate 121 beats/min, blood pressure 180/100 mm Hg, and temperature 38.9 °C. The patient reported diarrhea, nausea, dizziness, restlessness, and increased muscle pain. Her history included recurrent breast cancer first diagnosed in 1999, hypertension, fibromyalgia, depression, osteopenia, gastroesophageal reflux disease, insomnia, and endometriosis. Her home medications included milnacipran, fluoxetine, alprazolam, zolpidem, zoledronic acid, anastrozole, doxepin, ranitidine, levocetirizine, doxazosin, tramadol, vitamin D, and ferrous gluconate. The patient's increased heart rate, blood pressure, and temperature, as well as restlessness, self-reported diarrhea and nausea, and self-reported increase in muscle pain, indicated serotonin toxicity. Milnacipran, fluoxetine, and tramadol were discontinued, while doxepin was continued. Treatment consisted of acetaminophen, diphenhydramine, methylprednisolone, promethazine, and hydralazine 10 mg intravenously. The following morning all vital signs were within normal limits and the patient's diarrhea, nausea, dizziness, restlessness, and muscle pain resolved. She was discharged the following morning. The rash had resolved after day 2 of hospital discharge, which was the fourth day after discontinuation of milnacipran. DISCUSSION Given the patient's symptoms, the timing of symptom onset, the patient's history, and findings on physical examination, as well as use of the Naranjo probability scale, milnacipran was deemed the probable cause of the morbilliform reaction and serotonin toxicity. Only 1 case report of rash and 2 case reports of serotonin syndrome associated with milnacipran have been reported. CONCLUSIONS It is important to increase awareness of the possibility of developing morbilliform rash and serotonin toxicity with milnacipran therapy, as both conditions can be associated with poor outcomes if not detected early and treated appropriately.
Exergy Analysis of Oxidative Steam Reforming of Methanol for Hydrogen Producton: Modeling Study
Authors: Kumar Shashi , Katiyar Nisha , Kumar Surendra , Yadav Snigdha 
Published: July 2013

Abstract
Hydrogen production by oxidative steam reforming of methanol in a fixed bed catalytic reactor was modeled and simulated. The addition of O2 to feed reduced the temperature in the reformer. 99.86% conversion was obtained at 550 K and S/C molar ratio of unity in steam reforming while it is at 540 K in oxidative steam reforming. Although H2 and CO yields were decreased in oxidative steam reforming in comparison to steam reforming, the reductoin H2 yield was note significant whereas reduction in CO was appreciably high. The thermal and exergy efficiencies were favored by reforming temperature and S/C molar ratios. However, variation in S/C molar ratio showed negligibly small effect on efficiencies. The reforming temperature had a notable influence on the efficiencies. The exergy destruction was found to be lower at higher temperature and S/C molar ratio. Thus, oxidative steam reforming of methanol at 540 K and S/C molar ratio of unity utilizes sufficient amount of input energy in the form of useful work and thermodynamic irreversibilities in the reactor are quantitatively small.
Large Scale Full-Length cDNA Sequencing Reveals a Unique Genomic Landscape in a Lepidopteran Model Insect, Bombyx mori
Authors: Suetsugu Yoshitaka , Futahashi Ryo , Kanamori Hiroyuki , Kadono-Okuda Keiko , Sasanuma Shun-ichi , Narukawa Junko , Ajimura Masahiro , Jouraku Akiya , Namiki Nobukazu , Shimomura Michihiko , Sezutsu Hideki , Osanai-Futahashi Mizuko , Suzuki Masataka G , Daimon Takaaki , Shinoda Tetsuro , Taniai Kiyoko , Asaoka Kiyoshi , Niwa Ryusuke , Kawaoka Shinpei , Katsuma Susumu , Tamura Toshiki , Noda Hiroaki , Kasahara Masahiro , Sugano Sumio , Suzuki Yutaka , Fujiwara Haruhiko , Kataoka Hiroshi , Arunkumar Kallare P , Tomar Archana , Nagaraju Javaregowda , Goldsmith Marian R , Feng Qili , Xia Qingyou , Yamamoto Kimiko , Shimada Toru , Mita Kazuei 
Published: July 2013

Abstract
The establishment of a complete genomic sequence of silkworm, the model species of Lepidoptera, laid a foundation for its functional genomics. A more complete annotation of the genome will benefit functional and comparative studies and accelerate extensive industrial applications for this insect. To realize these goals, we embarked upon a large-scale full-length cDNA collection from 21 full-length cDNA libraries derived from 14 tissues of the domesticated silkworm and performed full sequencing by primer walking for 11,104 full-length cDNAs. The large average intron size was 1904 bp, resulting from a high accumulation of transposons. Using gene models predicted by GLEAN and published mRNAs, we identified 16,823 gene loci on the silkworm genome assembly. Orthology analysis of 153 species, including 11 insects, revealed that among three Lepidoptera including Monarch and Heliconius butterflies, the 403 largest silkworm-specific genes were composed mainly of protective immunity, hormone-related, and characteristic structural proteins. Analysis of testis-/ovary-specific genes revealed distinctive features of sexual dimorphism, including depletion of ovary-specific genes on the Z chromosome in contrast to an enrichment of testis-specific genes. More than 40% of genes expressed in specific tissues mapped in tissue-specific chromosomal clusters. The newly obtained FL-cDNA sequences enabled us to annotate the genome of this lepidopteran model insect more accurately, enhancing genomic and functional studies of Lepidoptera and comparative analyses with other insect orders, and yielding new insights into the evolution and organization of lepidopteran-specific genes.
Combinatorial Effects of Transposable Elements on Gene Expression and Phenotypic Robustness in Drosophila melanogaster Development
Authors: Clemmons Alexa W , Wasserman Steven A 
Published: July 2013

Abstract
Embryonic patterning displays remarkable consistency from individual to individual despite frequent environmental perturbations and diverse genetic contexts. Stochastic influences on the cellular environment may cause transcription rates to fluctuate, but these fluctuations rarely lead to developmental defects or disease. Here we characterize a set of recessive alleles of the Toll pathway component tube that destabilize embryonic dorsoventral patterning in Drosophila melanogaster. Females bearing these tube alleles generate embryos of an unusually wide range of dorsalized phenotypes, with the distributions across this range being unique for each allele. We determine that the mutant lines have in common a retrotransposon insertion upstream of the tube transcription start site. Genetic and molecular approaches demonstrate that this insertion dramatically reduces maternal expression of tube, thereby uncovering the inherent variability in gene expression. We further find that additional transposable element insertions near the tube gene synergistically enhance the phenotype caused by the sensitizing upstream insertion. These studies document how phenotypic variability can arise from normally occurring fluctuations around reduced mean expression and illustrate the contribution of transposons, individually and combinatorially, to such a state.
Fast Genomic Predictions via Bayesian G-BLUP and Multilocus Models of Threshold Traits Including Censored Gaussian Data
Authors: Kärkkäinen Hanni P , Sillanpää Mikko J 
Published: July 2013

AbstractBecause of the increased availability of genome-wide sets of molecular markers along with reduced cost of genotyping large samples of individuals, genomic estimated breeding values have become an essential resource in plant and animal breeding. Bayesian methods for breeding value estimation have proven to be accurate and efficient; however, the ever-increasing data sets are placing heavy demands on the parameter estimation algorithms. Although a commendable number of fast estimation algorithms are available for Bayesian models of continuous Gaussian traits, there is a shortage for corresponding models of discrete or censored phenotypes. In this work, we consider a threshold approach of binary, ordinal, and censored Gaussian observations for Bayesian multilocus association models and Bayesian genomic best linear unbiased prediction and present a high-speed generalized expectation maximization algorithm for parameter estimation under these models. We demonstrate our method with simulated and real data. Our example analyses suggest that the use of the extra information present in an ordered categorical or censored Gaussian data set, instead of dichotomizing the data into case-control observations, increases the accuracy of genomic breeding values predicted by Bayesian multilocus association models or by Bayesian genomic best linear unbiased prediction. Furthermore, the example analyses indicate that the correct threshold model is more accurate than the directly used Gaussian model with a censored Gaussian data, while with a binary or an ordinal data the superiority of the threshold model could not be confirmed.
Three-dimensional changes of the naso-maxillary complex following rapid maxillary expansion
Authors: Bouserhal Joseph , Bassil-Nassif Nayla , Tauk Alain , Will Leslie , Limme Michel 
Published: July 2013

ABSTRACT

Objective:
To assess the volumetric changes and the maxillary response of the naso-maxillary complex (NMC) following rapid maxillary expansion (RME).

Materials and Methods:
Thirty consecutive patients (14 males and 16 females) with a mean age at first observation of 9.5 ± 1.8 years for males and of 11.8 ± 1.7 years for females, presenting a posterior unilateral or bilateral crossbite and requiring RME, were selected for the study. Each patient underwent expansion to correct the transverse occlusal relationships. Computed tomography scans were taken before RME (T1) and at the end of the active expansion phase (T2). Measurements were performed on scanned images. The Kolmogorov-Smirnov test was performed; the mean differences between measurements at T1 and T2 were compared using the t-test (α  =  .05).

Results:
All volumetric, maxillary, transverse skeletal anterior and posterior variables as well as all dental anterior and posterior linear and angular variables representing the NMC displayed statistically highly significant increases after RME (P &lt; .001).

Conclusions:
After RME the total volume of the NMC increased by 12%, the nasal volume by 17%, and the maxillary volume by 10.6%. The maxillary and the nasal contributions represented 69.75% and 30.25%, respectively.
Human tooth movement by continuous high and low stresses
Authors: DeForest Whitney N. , Hentscher-Johnson Jodi K. , Liu Ying , Liu Hongzeng , Nickel Jeffrey C. , Iwasaki Laura R. 
Published: July 2013

ABSTRACT

Objective:
To compare three-dimensional tooth movements resulting from relatively higher and lower stresses in a split-mouth design.

Materials and Methods:
Eight volunteers whose maxillary first premolars were removed for orthodontic treatment participated. Each subject's maxillary canines were retracted by randomly assigned constant stresses of 78 kPa and 4 kPa via segmental mechanics. Dental casts depicting 8–10 visits per subject over 84 days and a three-axis microscope were used to measure movements serially. Descriptive statistics and mixed linear modeling were applied for data analyses (α  =  .05).

Results:
Teeth moved by 78 kPa had significantly faster (P  =  .0005) distal movement (0.066 ± 0.020 mm/day) compared to teeth moved by 4 kPa (0.031 ± 0.012 mm/day). Lateral movement and distopalatal rotation were also significantly faster (fourfold and 10-fold, respectively) with higher than with lower stress (P &lt; .0001). Average extrusion-intrusion, crown torque, and tip were small (≤ |0.25| mm, |2.29|°, and |1.98|°, respectively), fluctuated, and not significantly different between high and low stresses. No lag phase of tooth movement was evident.

Conclusions:
Maxillary canines were retracted faster by 78 kPa than by 4 kPa. Controlled translation was possible with 4 kPa, but 78 kPa outstripped appliance constraints, causing distopalatal rotation.
Alternative Preisbildungsmodelle – eine realitätsnahe Option?
Authors: Hartebrodt Christoph , Stenzel Falko 
Published: July 2013

Alternative pricing models – a realistic option?
The use of alternative pricing models as a means to automatize or at least facilitate the pricing of timber and thereby also reduce the volatility of timber prices has been under consideration for the past several years. The possibilities and limitations of such alternative pricing models are examined in this article using a retrospective comparative analysis. Overall, the results of six pricing models (these are: annual contract, quarterly contract, attenuation of the rate of change, mixed pricing, regression analysis derived price escalation clause, and self-fulfilling contract) are compared with the development of real timber prices between 2000 and 2010 of the state forest enterprise of Baden-Württemberg (Germany) and analyzed using a set of performance measures. It turns out that there is a conflict of objectives between determining the exact figure of the market price by alternative pricing models and reducing the volatility of timber prices. Thus, quarterly contracts show the market price well, though display no relevant volatility reduction effect; conversely, contracts with a defined attenuation rate lead to a substantial reduction of volatility but also to maximizing deviations from the market price. It is also questionable in how far price escalation clauses, that is, models which were calibrated from regression analysis on the basis of historical data, are able to predict the future development of market prices. At the moment, alternative pricing models can therefore hardly replace the real market-negotiated timber price. They can though support pricing negotiations between buyers and sellers, but primarily in time periods not characterized by a pronounced dynamic.
Upper‐Body Extracorporeal Membrane Oxygenation as a Strategy in Decompensated Pulmonary Arterial Hypertension
Authors: Abrams Darryl C. , Brodie Daniel , Rosenzweig Erika B. , Burkart Kristin M. , Agerstrand Cara L. , Bacchetta Matthew D. 
Published: July 2013

Pulmonary arterial hypertension (PAH) is a disease with significant morbidity and mortality, particularly during an acute decompensation. We describe a single‐center experience of three patients with severe Group 1 PAH, refractory to targeted medical therapy, in which an extubated, nonsedated, extracorporeal membrane oxygenation (ECMO) strategy with an upper‐body configuration was used as a bridge to recovery or lung transplantation. All three patients were extubated within 24 hours of ECMO initiation. Two patients were successfully bridged to lung transplantation, and the other patient was optimized on targeted PAH therapy with subsequent recovery from an acute decompensation. The upper‐body ECMO configuration allowed for daily physical therapy, including one patient, who would otherwise have been unsuitable for transplantation, ambulating over 850 meters daily. This series demonstrates the feasibility of using ECMO to bridge PAH patients to recovery or transplantation while avoiding the complications of immobility and invasive mechanical ventilation.
Provider Recognition and Response to Echocardiographic Findings Indicating Pulmonary Hypertension in the Veterans Affairs Medical Center Population
Authors: Kingrey John F. , Panos Ralph J. , Ying Jun , Meganathan Karthikeyan , Vandivier Robin , Elwing Jean M. 
Published: July 2013

PH occurs alone or in association with many disorders. Many patients with transthoracic echocardiography (TTE) findings suggesting PH never receive additional evaluation. Patient characteristics and echocardiographic data associated with increased recognition of PH have not been fully evaluated. We evaluated TTE reports at the Cincinnati Veterans Affairs Medical Center from 2005 to 2006 retrospectively for findings highly indicative of PH: Estimated systolic pulmonary artery pressure (sPAP) ≥40 mmHg, increased right atrial or right ventricular (RV) size, or reduced RV function. Only patients with left ventricular ejection fraction (LVEF) ≥50% and no known diagnosis of PH were included. Patient characteristics, TTE findings, provider recognition rates, and subsequent referral for additional evaluation were assessed. A total of 227 of 3,960 (5.7%) TTE reports revealed findings indicating possible PH. Providers acknowledged possible PH in 53 (23.4%) reports. Recognized PH was predicted by increased RV size (odds ratio (OR) = 5.07, P < 0.001), increased right atrial dimension (OR = 6.45, P < 0.001), decreased RV function (OR = 8.86, P < 0.001), and increased PAP (OR = 1.04 corresponding to each unit increase of PAP, P < 0.01). Patients with comorbid obstructive sleep apnea (OSA), interstitial lung disease, and dyspnea were also more likely to be recognized (OR = 3.63, P = 0.021; OR = 10.98, P = 0.004; OR = 2.39, P = 0.007, respectively). The 12‐month mortality rate for recognized patients, 11.3% (7/53), was lower than for unrecognized patients, 25.3% (44/174; P = 0.03). Providers recognized less than one in four patients with echocardiographic evidence suggesting PH. Echocardiography reports revealing higher PAP and right heart dilation and dysfunction are associated with increased acknowledgement of possible PH.
An in vitro Evaluation of Microleakage of Three Different Self-Etch Adhesives with Ethanol, Acetone and Water as Solvents
Authors: Bogra Poonam , Gupta Saurabh , Singh S Vijay , Kocchar Jyoti 
Published: July 2013

ABSTRACT

Purpose
The aim of this study is to evaluate and compare the microleakage of three different self-etch adhesives with ethanol, acetone and water as solvents.

Materials and methods
Standardized class V cavities were prepared on both facial and lingual surfaces of 60 caries-free human premolar teeth. The teeth were divided in three groups and different self-etch adhesives (OptiBond All in One, Tetric N Self-Etch, Adper Easy One) were applied according to manufacturer's instructions. The samples were then restored with composite and subjected to thermocycling. Later, the teeth were stained with methylene blue, sectioned and measured for microleakage under stereomicroscope.

Results
This study showed that at the occlusal margin and gingival margins, the preparations treated with OptiBond all in one showed significantly less leakage than the other groups. Enamel margins provided better marginal sealing than dentin/cementum margins.

Conclusion
The study demonstrated that OptiBond All in One bond had a better sealing ability at both occlusal and gingival margins compared with the other adhesives used.

Keywords
Microleakage, Self-etch adhesives, Solvents.

How to cite this article
Singh SV, Bogra P, Gupta S, Kocchar J. An in vitro Evaluation of Microleakage of Three Different Self- Etch Adhesives with Ethanol, Acetone and Water as Solvents. Int J Prosthodont Restor Dent 2012;2(3):83-87.
Attachment-retained Unilateral Distal Extension (Kennedy's Class II Modification I) Cast Partial Denture
Authors: Jain Ashish R , Philip Jacob Mathew 
Published: July 2013

ABSTRACT
Attachment-retained removable partial denture (RPD) is not an outdated treatment modality. It is even more contemporary in today's appearance-oriented society than when it was first introduced. There is significant number of patients who could benefit from this treatment option, both short and long term. However, lack of proper knowledge, overwhelming number of attachments available in the market, multiple adjustments and repairs are making dentists reluctant to offer and provide attachment-retained RPD services. The purpose of this article is to provide an overview and a simplified approach to this treatment modality by way of a case report.

How to cite this article
Jain AR, Philip JM, Ariga P. Attachment-retained Unilateral Distal Extension (Kennedy's Class II Modification I) Cast Partial Denture. Int J Prosthodont Restor Dent 2012;2(3):101-107.
Tooth Wear, Etiology, Diagnosis and Its Management in Elderly: A Literature Review
Authors: Nadiger Ramesh , Lekha K , Meshramkar Roseline 
Published: July 2013

ABSTRACT
The aim of the review was to present the importance of tooth wear, etiology and its management in elderly patients. The success of rehabilitation of tooth wear in elderly depends upon finding the etiology, correct diagnosis, prevention method and its management. Recognition of the early signs of tooth wear could bring about timely prevention and improve the life span of teeth in elderly.

How to cite this article
Meshramkar R, Lekha K, Nadiger R. Tooth Wear, Etiology, Diagnosis and Its Management in Elderly: A Literature Review. Int J Prosthodont Restor Dent 2012;2(3): 113-116.
Fluidics
Authors: Austin Suthanthiraraj Pearlson P. , Graves Steven W. 
Published: July 2013

AbstractThe use of fluidics is implicit in a technology named “flow cytometry,” which flows a cell or particle through a sensing volume to obtain serial analysis of particles on a one by one basis. This flow of particles enables flow cytometry to collect information on multiple particle populations, giving it a distinct advantage over bulk analysis approaches. Moreover, flow cytometers can analyze thousands of particles per second in a single flowing stream. Additionally, use of volumetric sample delivery makes it possible for flow cytometers to accurately count cells and particles. Furthermore, the analysis results can be coupled with a fluidic diversion mechanism to sort and collect particles based on desired properties. Finally, when high‐throughput sampling technologies are employed to rapidly change the input of the sample stream, a flow cytometer can become an integral tool for high‐throughput screening. The above properties have made flow cytometry useful in a wide range of biomedical applications. In this unit we will present an overview of fluidic systems that make flow cytometry possible. This will introduce historical approaches, explanations of the commonly implemented current fluidics, and brief discussions of potential future fluidics where appropriate. Curr. Protoc. Cytom. 65:1.2.1‐1.2.14. © 2013 by John Wiley & Sons, Inc.