bluuebunny/crossref_metadata_2025_split huggingface dataset:
Systematic Monitoring and Treatment of Physical Symptoms to Alleviate Fatigue in Patients With Advanced Cancer: A Randomized Controlled Trial
Authors: de Raaf Pleun J. , de Klerk Cora , Timman Reinier , Busschbach Jan J.V. , Oldenmenger Wendy H. , van der Rijt Carin C.D. 
Published: January 2013

Purpose Several guidelines on the treatment of cancer-related fatigue recommend optimizing treatment of accompanying symptoms. However, evidence for this recommendation from randomized clinical trials is lacking. We investigated whether monitoring and protocolized treatment of physical symptoms alleviates fatigue. Patients and Methods In all, 152 fatigued patients with advanced cancer were randomly assigned to protocolized patient-tailored treatment (PPT) of symptoms or care as usual. The PPT group had four appointments with a nurse who assessed nine symptoms on a 0 to 10 numeric rating scale (NRS). Patients received a nonpharmacologic intervention for symptoms with a score ≥ 1 and a medical intervention for symptoms with a score ≥ 4. Fatigue dimensions, fatigue NRS score, interference of fatigue with daily life, symptom burden, quality of life, anxiety, and depression were measured at baseline and after 1, 2, and 3 months. Differences between the groups over time were assessed by using mixed modeling. Results Seventy-six patients were randomly assigned to each study arm. Mean age was 58 ± 10 years, 57% were female, and 65% were given palliative chemotherapy. We found significant improvements over time in favor of PPT for the primary outcome general fatigue (P = .01), with significant group differences at month 1 (effect size, 0.26; P = .007) and month 2 (effect size, 0.35; P = .005). Improvements in favor of PPT were also found for the following secondary outcomes: fatigue dimensions “reduced activity” and “reduced motivation,” fatigue NRS, symptom burden, interference of fatigue with daily life, and anxiety (all P ≤ .03). Conclusion In fatigued patients with advanced cancer, nurse-led monitoring and protocolized treatment of physical symptoms is effective in alleviating fatigue.
Role of Surgery in the Treatment of Patients With Stage 4 Neuroblastoma Age 18 Months or Older at Diagnosis
Authors: Simon Thorsten , Häberle Beate , Hero Barbara , von Schweinitz Dietrich , Berthold Frank 
Published: January 2013

Purpose Although intensive multimodal treatment has improved the prognosis of patients with metastatic neuroblastoma, the impact of primary tumor resection on outcome is a matter of medical debate. Patients and Methods Patients from the German prospective clinical trial NB97 with stage 4 neuroblastoma and age 18 months or older at diagnosis were included. Operation notes and imaging reports were reviewed by two independent experienced physicians. Finally, the extent of tumor resections was correlated with local control rate and outcome. Results A total of 278 patients were included in this study. Image-defined risk factors present at diagnosis were found to be predictive for the extent of tumor resection at first (P < .001) and best (P < .001) operation. No patient died from surgery. Before chemotherapy, complete resection, incomplete resection, and biopsy or no surgery were performed in 6.1%, 5.0%, and 88.5% of patients, respectively. The extent of first operation had no impact on event-free survival (EFS; P = .207), local progression–free survival (LPFS; P = .195), and overall survival (OS; P = .351). After induction chemotherapy, 54.7% of patients underwent complete resection of the primary tumor, 30.6% underwent incomplete resection, and 13.3% had only biopsy or no surgery of the primary tumor. The extent of best operation also had no impact on EFS (P = .877), LPFS (P = .299), and OS (P = .778). Moreover, multivariate analyses showed that surgery did not affect EFS, LPFS, and OS. Conclusion In intensively treated patients with stage 4 neuroblastoma age 18 months or older at diagnosis, surgery of the primary tumor site has no impact on local control rate and outcome.
Effect of a 300 000-IU Loading Dose of Ergocalciferol (Vitamin D2) on Circulating 1,25(OH)2-Vitamin D and Fibroblast Growth Factor-23 (FGF-23) in Vitamin D Insufficiency
Authors: Turner C. , Dalton N. , Inaoui R. , Fogelman I. , Fraser W. D. , Hampson G. 
Published: January 2013

Abstract

Context:
Several trials have reported an increased risk of fractures and falls after intermittent high-dose vitamin D. Treatment with loading doses of vitamin D may increase 1,25(OH)2 vitamin D catabolism through changes in calcium/phosphate homeostasis and fibroblast growth factor-23 (FGF-23).

Objective:
The aim was to determine the effects of high-dose vitamin D on circulating concentrations of 1,25(OH)2 vitamin D and FGF-23 in patients with osteoporosis and vitamin D insufficiency.

Design, Setting, Patients, and Intervention:
We carried out a prospective study of 45 subjects with vitamin D deficiency/insufficiency treated with a bolus dose of 300 000 IU of vitamin D2 im. Blood samples were obtained at baseline and 1, 2, and 3 months after treatment.

Outcome Measures:
Changes in 1,25(OH)2-vitamin D and FGF-23 were measured.

Results:
Loading dose of vitamin D2 increased 1,25(OH)2-vitamin D2 at 3 months, with a mean [SD] of 41 [56] pmol/L at baseline and 162.3 [137.8] pmol/L at 3 months (P &lt; .001). FGF-23 increased significantly at all time points with a peak at 3 months, with percent change from baseline (mean [SEM]) of 50% [48%] at 3 months (P &lt; .01). There was a positive correlation between FGF-23 and serum phosphate (r = 0.36, P = .024) and calcium (r = 0.532, P &lt; .001) and a negative correlation between total 1,25(OH)2-vitamin D and FGF-23 (r = −0.32, P = .036) at 3 months.

Conclusions:
High-dose vitamin D increases 1,25(OH)2-vitamin D and FGF-23 concentration. Further studies are required to determine whether adjusting vitamin D dose and frequency to minimize increases in FGF-23 may prevent the adverse outcomes associated with high-dose intermittent vitamin D supplementation.
Comments by the Auditing Standards Committee of the Auditing Section of the American Accounting Association on the IESBA Proposal, Responding to a Suspected Illegal Act
Authors: Curtis Mary B. , Pany Kurt J. , Pevzner Mikhail , Robertson Jesse C. , Zhang Jian 
Published: January 2013

SUMMARY
Recently, the International Ethics Standards Board for Accountants (IESBA) solicited public comments on their proposal to revise their standard of reporting on suspected illegal acts. This commentary summarizes the contributors' views on the various alternatives proposed in the IESBA proposal entitled, Responding to a Suspected Illegal Act. The exposure draft (which invited comments through December 15, 2012) can be found at http://www.ifac.org/sites/default/files/publications/files/IESBA-Code-of-Ethics-Illegal-Acts-Exposure-Draft.pdf. Our comments submitted to the IESBA appear below.
Detection of Financial Statement Fraud Using Evolutionary Algorithms
Authors: Alden Matthew E. , Bryan Daniel M. , Lessley Brenton J. , Tripathy Arindam 
Published: January 2013

ABSTRACT
In this paper, we use a Genetic Algorithm (GA) and MARLEDA—a modern Estimation of Distribution Algorithm (EDA)—to evolve and train several fuzzy rule-based classifiers (FRBCs) to detect patterns of financial statement fraud. We find that both GA and MARLEDA demonstrate a better ability to classify unseen corporate data observations than those of a traditional logistic regression model, and provide validity for detecting financial statement fraud with Evolutionary Algorithms (EAs) and FRBCs. Using ten-fold cross-validation, the GA and MARLEDA yield average training classification accuracy rates of 75.47 percent and 74.26 percent, respectively, and average validation accuracy rates of 63.75 percent and 64.46 percent, respectively.
Distribution and growth of brown trout in pristine headwaters of Central Europe
Authors: Závorka Libor , Horký Pavel , Slavík Ondřej 
Published: January 2013

AbstractThe majority of stream-dwelling salmonid populations in Europe are affected by artificial stocking and the fragmentation of riverine ecosystems. The present study was performed in the unique pristine headwaters of the Otava River in the Elbe catchment area of the Czech Republic. The aim was to investigate the spatial distribution and individual growth pattern of brown trout, Salmo trutta, populations. Twenty sites in two main streams and their tributaries were sampled twice a year (spring and autumn) during the period 2005–2011. The sampling sites were grouped into fourteen so-called synchronised population units within the boundaries of three populations, according to analyses of synchrony in population abundance. The individual growth of juveniles (age-0, age-1) varied between all three spatial units (sampling sites, synchronised population units and populations), while the individual growth of adults (age-2 and older) did not. The distinctiveness regarding individual growth and demographic independence among the synchronised population units and populations indicates their suitability for use as population units for management purposes.
Role of cell surface hydrophobicity in Candida albicans biofilm
Authors: Bujdáková Helena , Didiášová Miroslava , Drahovská Hana , Černáková Lucia 
Published: January 2013

AbstractOverall cell surface hydrophobicity (CSH) is predicted to play an important role during biofilm formation in Candida albicans but is the result of many expressed proteins. This study compares the CSH status and CSH1 gene expression in C. albicans planktonic cells, sessile biofilm, and dispersal cells. Greater percentages of hydrophobic cells were found in non-adhered (1.5 h) and dispersal forms (24 or 48 h) (41.34±4.17% and 39.52±7.45%, respectively), compared with overnight planktonic cultures (21.69±3.60%). Results from quantitative real-time PCR confirmed greater up-regulation of the CSH1 gene in sessile biofilm compared with both planktonic culture and dispersal cells. Up-regulation was also greater in dispersal cells compared with planktonic culture. The markedly increased CSH found both in C. albicans biofilm, and in cells released during biofilm formation could provide an advantage to dispersing cells building new biofilm.
Block-based motion estimation algorithms — a survey
Authors: Jakubowski M. , Pastuszak G. 
Published: January 2013

AbstractIn the multi-view video coding, both temporal and inter-view redundancies can be exploited by using standard block-based motion estimation (BBME) technique. In this paper, an extensive review of BBME algorithms proposed within the last three decades is presented. Algorithms are divided into five categories: 1) based on the search position number reduction; 2) multiresolution; 3) based on the simplification of matching criterion; 4) fast full search; 5) computation-aware. Algorithms are compared in terms of their efficiency and computational complexity.
Synthesis and Luminescent Properties of Strontium Cerium Oxide Phosphors Doped with Rare Earths
Authors: Nannapaneni P. R. V. , Rao C. A. , Murthy K. V. R. 
Published: January 2013

In this paper we report the synthesis and luminescent properties of Sr2CeO4 doped with rare earths (0.5% concentration of La, Eu and Dy ions) are reported. The powder samples of rare earths doped strontium cerium oxide (Sr2CeO4: La, Eu and Dy ions) was synthesized by a standard solid state reaction method in air at 12000C. These samples were characterized by X-ray diffraction, scanning electron microscope (SEM) and photoluminescence (PL) techniques, particle size analysis. The XRD data revealed that the structure of the Sr2CeO4 as orthorhombic and the calculated average crystallite size is ~10nm. Scanning electron microscopy revealed that the Sr2CeO4 phosphor particles had non-spherical shape and the irregular shaped particles are highly agglomerated. PL excitation and emission spectra of Sr2CeO4 doped with rare earths are recorded at room temperature. The CIE coordinates depicted on 1931 chart of Eu (0.5%) doped Sr2CeO4 shown that the emission colour varies from blue to white. This phosphor has a good potential for application in white light LEDs.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.10965 J. Sci. Res. 5 (1), 1-11 (2013)
Hardfacing of AISI 1020 Steel by Arc Welding in Comparison with TIG Welding Processes
Authors: Pradeep G. R. C. , Ramesh A. , Durga Prasad B. 
Published: January 2013

Hardfacing techniques are used for enhancing the life of various machine parts by rebuilding the worn out or eroded or corroded areas in them. In this paper, an attempt has been made to determine the better welding process to hardface AISI 1020 steel based on study of wear and other factors. Two types of welding processes - Arc welding and tungsten inert gas welding (TIG) have been compared. The study revealed that the specimens prepared using TIG welding process yielded better wear properties compared to the specimen prepared using Arc welding process till 1.256 m/s sliding velocity. Also it was observed that the Arc welding process yielded better wear properties for sliding velocities above 1.571 m/s. An attempt was made to study the reasons for getting the said results.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.11899 J. Sci. Res. 5 (1), 119-126 (2013)
Theoretical investigation on Elastic, Thermodynamic and Optical Properties of Li<sub>3</sub>P Ionic Conductor
Authors: Hossain M. A. , Islam A. K. M. A. 
Published: January 2013

The elastic, thermodynamic and optical properties of Li3P have been studied for the first time using the plane-wave ultrasoft pseudopotential technique which is based on the first-principles density functional theory (DFT) with generalized gradient approximation (GGA). The optimized lattice parameters, independent elastic constants, Youngs modulus E, bulk modulus B, shear modulus G, Cauchys pressure, Pughs ductility index (G/B), and Poissons ratio ? have been calculated and discussed. The temperature and pressure dependence of bulk modulus, Debye temperature, specific heats, and volume thermal expansion coefficient are all obtained through the quasi-harmonic Debye model with phononic effects for T = 0-1000 K and P = 0-35 GPa. The large reflectivity in the ultraviolet energy region between 7  13.4 eV indicates the material to be a good candidate as coating to avoid solar heating.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.12413 J. Sci. Res. 5 (1), 33-42 (2013)
Evaluation of CKD-EPI and MDRD Prediction Equations for Estimation of GFR in Lean and Obese Bangladeshi Subjects
Authors: Saiedullah M. , Begum S. , Rahman M. R. , Khan M. A. H. , Hayat S. , Kamaluddin S. M. , Shaheen M. A. H. 
Published: January 2013

Glomerular filtration rate (GFR) is the filtrate produced by the kidneys in each minute. Chronic kidney disease epidemiology (CKD-EPI) and standardized modification of diet in renal disease (MDRD) equations are the commonly used equations to estimate GFR. Evaluation of GFR prediction equations regarding body mass index is not available in Bangladeshi population. In this study we compared estimated GFR (eGFR) with GFR measured by creatinine clearance rate (CCR) in lean and obese Bangladeshi subjects. Measured GFR were 40±21 and 45±22 ml/min/1.73m2 in lean and obese groups, respectively. Compared to measured GFR, estimated GFRs were 7.5 (p<0.0001), 5.2 (p<0.0001) ml/min/1.73m2 higher for CKD-EPI and MDRD four variables (MDRD4) equations in lean group and 6.9 (p<0.0001), 3.2 (p>0.05) ml/min/1.73 m2 higher for CKD-EPI and MDRD4 equations in obese group. The precision (r2) was 0.6461 for CKD-EPI, 0.6508 for MDRD4 equations in lean group and 0.6337 for CKD-EPI and 0.6021 for MDRD4 equations in obese group. The percentages of eGFR falling within 15% measured GFR were 37 for CKD-EPI, 52 for MDRD4 in lean group; 41 for CKD-EPI, 39 for MDRD4 in obese group. CKD-EPI equation overestimates GFR in both lean and obese, but MDRD4 equation overestimates GFR only in lean Bangladeshi subjects.© 2013 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved.doi: http://dx.doi.org/10.3329/jsr.v5i1.8764 J. Sci. Res. 5 (1), 207-213 (2013)
Is Transition between Peritoneal Dialysis and Hemodialysis Really a Gradual Process?
Authors: Boissinot Lucie , Landru Isabelle , Cardineau Eric , Zagdoun Elie , Ryckelycnk Jean-Philippe , Lobbedez Thierry 
Published: January 2013

Background Transfer to hemodialysis (HD) is a frequent cause of peritoneal dialysis (PD) cessation. In the present study, we set out to describe the transition period between PD and HD. Methods All patients in 4 centers of Basse-Normandie who had been treated with PD for more than 90 days and who were permanently transferred to HD between 1 January 2005 and 31 December 2009 were retrospectively reviewed. The rate of unplanned HD start was evaluated. Results In the 60 patients (39 men, 21 women) included in the study, median score on the Charlson comorbidity index at PD initiation was 5 [interquartile range (IQR): 3 – 7], median age at HD initiation was 62 years (IQR: 54 – 76 years), and median duration on PD was 22 months (IQR: 12 – 36 months). Among the 60 patients, 37 had an unplanned HD initiation. Peritonitis was the most frequent cause of unplanned HD start ( n = 20), and dialysis inadequacy ( n = 11), the main cause of planned HD start. During the transition period, all patients were hospitalized. Median duration of hospitalization was 4.5 days (IQR: 0 – 25.5 days). Within 2 months after HD initiation, 9 patients died. Two months after starting HD, 6 of the remaining 51 patients were being treated in a self-care HD unit and only 23 patients had a mature fistula. Conclusions Unplanned HD start is a common problem in patients transferred from PD. Further studies are needed to improve the rate of planned HD start in PD patients transferred to HD.
The Effect of Low-GDP Solution on Ultrafiltration and Solute Transport in Continuous Ambulatory Peritoneal Dialysis Patients
Authors: Cho Kyu-Hyang , Do Jun-Young , Park Jong-Won , Yoon Kyung-Woo , Kim Yong-Lim 
Published: January 2013

Background Several studies have reported benefits for human peritoneal mesothelial cell function of a neutral-pH dialysate low in glucose degradation products (GDPs). However, the effects of low-GDP solution on ultrafiltration (UF), transport of solutes, and control of body water remain elusive. We therefore investigated the effect of low-GDP solution on UF, solute transport, and control of body water. Methods Among 79 new continuous ambulatory peritoneal dialysis (CAPD) patients, 60 completed a 12-month protocol (28 in a lactate-based high-GDP solution group, 32 in a lactate-based low-GDP solution group). Clinical indices—including 24-hour UF volume (UFV), 24-hour urine volume (UV), residual renal function, and dialysis adequacy—were measured at months 1, 6, and 12. At months 1, 6, and 12, UFV, glucose absorption, 4-hour dialysate-to-plasma (D/P) creatinine, and 1-hour D/P Na+ were assessed during a modified 4.25% peritoneal equilibration test (PET). Body composition by bioelectric impedance analysis was measured at months 1 and 12 in 26 CAPD patients. Results Daily UFV was lower in the low-GDP group. Despite similar solute transport and aquaporin function, the low-GDP group also showed lower UFV and higher glucose absorption during the PET. Factors associated with UFV during the PET were lactate-based high-GDP solution and 1-hour D/P Na+. No differences in volume status and obesity at month 12 were observed, and improvements in hypervolemia were equal in both groups. Conclusions Compared with the high-GDP group, the low-GDP group had a lower UFV during a PET and a lower daily UFV during the first year after peritoneal dialysis initiation. Although the low-GDP group had a lower daily UFV, no difficulties in controlling edema were encountered.
Adorno et les antinomies de l'industrie culturelle
Authors: Traverso Enzo 
Published: January 2013

Résumé Le concept d’« industrie culturelle » se situe au croisement du pessimisme culturel allemand, de la théorie wébérienne de la rationalité et de la théorie marxiste de la réification. Theodor W. Adorno l’élabore dans une double confrontation avec Walter Benjamin, dont il reprend l’idée du déclin de l’aura de l’œuvre d’art dans le monde industriel, et Siegfried Kracauer, dont il récuse la vision de l’image comme moyen de connaissance. À cinquante ans de distance, son essai apparaît à la fois prémonitoire et myope : prémonitoire, car la réification de la culture a connu des développements à l’époque insoupçonnables ; et myope, car l’art et la création ne sont pas morts, en dépit de leur forme marchande.
Résurgences du passé
Authors: Ribert Évelyne 
Published: January 2013

Résumé Aux trois types d’oubli distingués par Marc Ferro font écho aujourd’hui, vingt-trois ans plus tard, dans un contexte de prolifération mémorielle, trois formes de résurgences du passé : les lois mémorielles, les mouvements visant à faire connaître les pans occultés et en général honteux du passé, enfin les productions artistiques fondées sur l’exhibition du vide et sur la restitution de la quête de la mémoire. Ces résurgences du passé montrent qu’il n’y a pas véritablement oubli. Elles posent la question des relations entre l’histoire officielle et la mémoire des individus.
Adoption internationale, familles et enfants dits « à besoins spéciaux »
Authors: Chicoine Jean-François , Germain Patricia , Lemieux Johanne 
Published: January 2013

Résumé Faciliter l’adoption internationale d’enfants dits « à besoins spéciaux » est une action humaine, morale et civique, dont la légitimité, par ailleurs totalement défendable, est en harmonie avec le principe de l’intérêt supérieur de l’enfant. Cette manière de concrétiser des adoptions a pourtant ses conséquences sur l’enfant, d’ailleurs en partie tributaires des impacts stressants sur ses nouveaux parents, ainsi que des effets de complexification sur la pratique des experts médico-sociaux œuvrant auprès des arrivants et leurs familles. À notre avis, une implication magnifiée des équipes psychosociales et des consultants médico-nursing s’impose urgemment en la matière, et ce, selon les rôles respectifs de tout un chacun, à toutes les étapes du processus adoptif, d’autant qu’en l’absence de recherches prospectives sur les réalités concrètes qui sous-tendent la question, nous demeurons convaincus que c’est la définition même du concept et ses conséquences anticipées qui posent problème.