bluuebunny/crossref_metadata_2025_split huggingface dataset:
The Affective Charge of Sulphur and Salt in Working with Compulsion
Authors: Giaccardi Giorgio 
Published: July 2024

AbstractThe author presents a long analysis of a patient, Giulia, whose obstinate will to achieve evokes the workings of alchemical sulphur at its fieriest and a dread of its coniunctio with alchemical salt. Jung's description of these symbols in Mysterium Coniunctionis offers a useful imaginal perspective to clinical work in the area of compulsion and its possible transformations.Right from the start, the analytic relationship appeared to be mirrored and affected by this alchemical perspective. However, it was only after much time, uncertainty and emotional endurance that a fuller psychological experience of sulphur and salt could be accessed, allowing the analysis to take a more imaginative and mercurial turn.In the course of his work with Giulia the author has witnessed and experienced a range of intense affects—the many colours that the combustion of sulphur can generate—whether on the verge of unstoppable creation or ruthless destruction, often of archetypal intensity. This experience has been lived through and has undergone a transformative relation with salt, which until then had lived a dissociated existence in the fixed trauma of the compulsion and in a nocturnal underworld of tears.
Long‐term trends in incidence and outcomes of rib fractures: A population‐based data linkage study from New South Wales, Australia
Authors: Salmon Eliot , Oliver Matthew , Bein Kendall , Berry Melanie , Partyka Christopher , Seimon Radhika , Singh Hardeep , Dinh Michael 
Published: July 2024

AbstractObjectiveDetermine long‐term trends in population‐based incidence and outcomes of rib fracture hospitalisations.MethodsThis was a data linkage study of rib fracture cases identified between 2015 and 2022 in New South Wales, Australia. Routinely collected health data were linked between ED, admitted patient and death registry data collection. The primary outcomes were age‐specific incidence of rib fracture hospitalisation cases and risk‐adjusted 30 days mortality. Other outcomes of interest were hospital length of stay (LOS), admission rate and ICU admissions.ResultsA total of 70 609 cases were analysed. Overall, the number of rib fracture hospitalisations increased by 25% between 2015 and 2022. The highest proportion of cases was in the 45–65 years (28%) and 65–85 years (31%) age groups. On a per population basis, the incidence rate increased by 2% per annum. After adjusting for age, comorbidity and injury severity, there was no significant trend in 30 days mortality observed between 2015 and 2022. The median inpatient LOS was 4 days with 38% of patients staying 1–2 days. Regional and rural areas were associated with more severe chest injuries.ConclusionRib fracture hospitalisations have increased with older patients driving this trend.
Productivity‐led Pathways to Sustainable Agricultural Growth: Six Decades of Progress
Authors: Jelliffe Jeremy , Fuglie Keith , Morgan Stephen 
Published: July 2024

SummaryIn recent decades, world agriculture has undergone a vast transformation. Between 1961 and 2020, global agricultural output increased nearly four‐fold while population grew 2.6 times, leading to a 53 per cent increase in output per capita. Real food prices declined, providing for more affordable and diverse diets. There was a pronounced and sustained shift in the location of production to the Global South (developing countries), which increased its share of global agricultural output from 44 to 73 per cent. Since the 1990s, increases in agricultural total factor productivity (TFP) has become the major driver of world agricultural output. However, insufficient productivity growth relative to demand has drawn more resources into agriculture. Globally, agricultural land area expanded 7.6 per cent between 1961 and 2020, although it contracted in the Global North (developed countries). In the EU, where agricultural output has remained relatively flat in recent decades, improvements in productivity reduced total inputs and environmental resources used by the sector. In contrast, in Canada‐United States, productivity growth enabled agricultural output to expand without increasing total inputs and environment resources. By the decade of the 2010s, however, the pace of output and productivity growth in world agriculture slowed, real food prices rose, the number of food insecure people increased, and pressure to expand the use of natural and environmental resources to produce food intensified.
Phagotrophy in the nitrogen‐fixing haptophyte Braarudosphaera bigelowii
Authors: Mak Esther Wing Kwan , Turk‐Kubo Kendra A. , Caron David A. , Harbeitner Rachel C. , Magasin Jonathan D. , Coale Tyler H. , Hagino Kyoko , Takano Yoshihito , Nishimura Tomohiro , Adachi Masao , Zehr Jonathan P. 
Published: July 2024

AbstractBiological nitrogen fixation provides fixed nitrogen for microbes living in the oligotrophic open ocean. UCYN‐A2, the previously known symbiont of Braarudosphaera bigelowii, now believed to be an early‐stage B. bigelowii organelle that exchanges fixed nitrogen for fixed carbon, is globally distributed. Indirect evidence suggested that B. bigelowii might be a mixotrophic (phagotrophic) phototrophic flagellate. The goal of this study was to determine if B. bigelowii can graze on bacteria using several independent approaches. The results showed that B. bigelowii grazed on co‐occurring bacteria at a rate of 5–7 cells/h/B. bigelowii and that the overall grazing rate was significantly higher at nighttime than at daytime. Bacterial abundance changes, assessed with 16S rRNA gene amplicon sequencing analysis, may have indicated preferential grazing by B. bigelowii on specific bacterial genotypes. In addition, Lysotracker™ staining of B. bigelowii suggested digestive activity inside B. bigelowii. Carbon and nitrogen fixation measurements revealed that the carbon demand of B. bigelowii could not be fulfilled by photosynthesis alone, implying supplementation by heterotrophy. These independent lines of evidence together revealed that B. bigelowii engages in phagotrophy, which, beyond serving as a supplementary source of carbon and energy, may also facilitate the indirect assimilation of inorganic nutrients.
Clinical characteristics and prognosis of primary thymic adenocarcinoma: A single‐center retrospective analysis
Authors: Hong Qian , Han Rui , Chen Chen , Wang Fuquan , Zhang Sining , Zhao Chenguang , Li Fang , Mu Juwei , Li Jiagen 
Published: July 2024

AbstractBackgroundPrimary thymic adenocarcinoma (PTAC) is an extremely rare disease with a poor prognosis. In the present study, we sought to analyze the clinical characteristics and prognostic factors of patients with PTAC.MethodsA total of 14 patients with PTAC treated at our center from January 2000 to January 2019 were included in this study. We retrospectively collected information on sex, age, history of smoking, family history of cancer, comorbidities, symptoms, imaging tests, serum tumor marker levels, tumor, node, metastasis (TNM) staging, and treatment records. Follow‐up information was obtained by telephone interviews or outpatient clinic visit. Univariate and multivariate Cox regression analyses were performed to investigate the clinicopathological factors associated with survival.ResultsAmong 14 patients with PTAC, there were five males and nine females, with an average age of 48.7 ± 9.3 years. A total of 23.1% of the patients had a history of smoking. The clinical symptoms of the patients were nonspecific and seven patients had elevated levels of serum tumor markers. Surgery was performed for nine patients, among which only four received R0 resection. The median survival time of the 14 patients was 16.0 months, and the 1‐, 3‐ and 5‐year survival rates were 57.1%, 35.7% and 21.4%, respectively. TNM stage was identified as an independent prognostic factor for PTAC patients (the median survival time of stage I–IIIA vs. stage IV was 44.0 months vs. 9.0 months, p = 0.002).ConclusionsPTAC is highly aggressive malignancy with poor prognosis. Surgical treatment is feasible, but R0 resection is challenging. TNM staging is significantly associated with patient survival.
Benchmarking imputation methods for categorical biological data
Authors: Gendre Matthieu , Hauffe Torsten , Pimiento Catalina , Silvestro Daniele 
Published: July 2024

Abstract

Trait datasets are at the basis of a large share of ecology and evolutionary research, being used to infer ancestral morphologies, quantify species extinction risks, or evaluate the functional diversity of biological communities. These datasets, however, are often plagued by missing data, for instance, due to incomplete sampling, limited data and resource availability. Several imputation methods exist to predict missing values and recent studies have explored their performance for continuous traits in biological datasets. However, less is known about the accuracy of these methods for categorical traits.

Here we explore the performance of different imputation methods on categorical biological traits combining phylogenetic comparative methods, machine learning and deep learning models. To this end, we develop an open‐source R package, to impute trait data while integrating a simulation framework to evaluate their performance on synthetic datasets. We run a range of simulations under different missing rates, mechanisms, biases and evolutionary models.

We propose an integration between phylogenetic comparative methods and machine learning imputation, and an ensemble approach, in which selected imputation methods are combined. Our simulations show that this approach provides the most robust and accurate predictions. We applied our imputation pipeline to an incomplete trait dataset of 1015 elasmobranch species (i.e. sharks, rays and skates) and found a high imputation accuracy of the predictions based on an expert‐based assessment of the missing traits.

Overall, our R package facilitates the comparison of multiple imputation methods and allows robust predictions of missing trait values. Our study highlights the benefits of coupling phylogenetic evolutionary models with machine learning inference to augment incomplete biological datasets.
Female directors and cash holdings adjustment: Evidence from South Korea
Authors: Aier Jagadison K. , Jo Eun Hye , Lee Jung Wha (Jenny) 
Published: July 2024

AbstractThis paper investigates whether female board participation improves a firm's efforts to manage its cash holdings in Korea. We find that firms with female directors quickly adjust their cash holdings towards the target, particularly when they have excess cash, suggesting that female directors are more likely to respond to anticipated problems related to excess cash relative to liquidity problems that may arise on account of a cash shortage. Furthermore, the relationship between female directors and cash holding adjustment is stronger for non‐chaebol affiliates, female‐friendly companies, and non‐controversial business environments.
A meeting report from SEAIP‐2023: Priorities and strategies
Authors: Ting Rachel Sing‐Kiat , Lee Boon‐Ooi , Perez Maireen Joy N. , Muhiddin Syurawasti , Liem Andrian , Balmores‐Paulino Rozel , Cleofe Myreen P. , Gallardo Maria Theresa B. , Jones Liz 
Published: July 2024

AbstractThis report introduces the development of the Southeast Asian Indigenous Psychology (SEAIP) network and the outcomes of the SEAIP‐2023 conference. First, we summarize four priorities of SEAIP research that evolved throughout the years; next, we propose four action plans in translating our research into practice. Our report aims to inspire Asian psychologists, especially the younger generation of scholars, to join and contribute to the development of this network.
Real‐world comparative effectiveness of venetoclax‐obinutuzumab versus Bruton tyrosine kinase inhibitors for frontline chronic lymphocytic leukaemia
Authors: Ghosh Nilanjan , Manzoor Beenish S. , Fakhri Bita , Emechebe Nnadozie , Alhasani Hasan , Skarbnik Alan , Jawaid Dureshahwar , Shadman Mazyar 
Published: July 2024

SummaryReal‐world evidence comparing clinical outcomes between venetoclax and Bruton tyrosine kinase inhibitors (BTKis) in patients with frontline (1 L) chronic lymphocytic leukaemia (CLL) is lacking. We compared treatment effectiveness of 1 L venetoclax plus obinutuzumab (VenO) versus BTKi‐based regimens. This retrospective observational study using Optum Clinformatics Data Mart® included adult patients with CLL (≥2 outpatient or ≥1 inpatient claim) who received VenO or BTKi‐based regimens in 1 L (1/2019–9/2022). Baseline characteristics were balanced using stabilised inverse probability weighting. Outcomes included duration of therapy (DoT), persistence, time to next treatment or death (TTNT‐D), and time off‐treatment. Among 1506 eligible patients (VenO: 203; BTKi: 1303), the median follow‐up duration was 12.6 (VenO) and 16.2 months (BTKi). Median DoT for VenO was 12.3 months; persistence remained higher in VenO versus BTKi through expected 1 L fixed treatment duration. Median TTNT‐D was not reached for VenO; however, more VenO‐ versus BTKi‐treated patients had not switched therapies/experienced death through Month 12 (87.1% vs. 75.3%). Among patients that discontinued, median time to discontinuation was 11.7 vs. 5.9 months for VenO versus BTKi and median time off‐treatment was 11.3 vs. 4.3 months. In this real‐world study, VenO was associated with better effectiveness outcomes than BTKi‐based regimens in 1 L CLL.
Reduced‐intensity conditioning with fludarabine/busulfan versus fludarabine/low‐dose melphalan in patients with non‐Hodgkin lymphoma undergoing allogeneic haematopoietic stem cell transplantation
Authors: Kamijo Kimimori , Shimomura Yoshimitsu , Kim Sung‐Won , Ohigashi Hiroyuki , Ishikawa Jun , Eto Tetsuya , Hiramoto Nobuhiro , Mizuno Ishikazu , Iida Shinsuke , Ueda Yasunori , Matsuoka Ken‐ichi , Yakushijin Kimikazu , Mori Yasuo , Onizuka Makoto , Fukuda Takahiro , Atsuta Yoshiko , Kako Shinichi 
Published: July 2024

SummaryReduced‐intensity conditioning regimens are commonly used in allogeneic haematopoietic cell transplantation for non‐Hodgkin lymphoma (NHL); however, the optimal regimen remains unknown. In this study, the outcomes of adult patients with NHL who received fludarabine plus reduced‐dose busulfan (6.4 mg/kg; Flu/Bu2) (n = 286) and fludarabine plus low‐dose melphalan (80 or 100 mg/m2; Flu/Mel80–100) (n = 283) between January 2009 and December 2020 were compared using Japanese registry data. The primary end‐point was the 5‐year overall survival (OS). The 5‐year OS was 53.8% (95% CI, 47.6–59.6) and 42.4% (95% CI, 35.6–49.0) in the Flu/Bu2 and Flu/Mel80–100 groups respectively (p = 0.030). After inverse probability of treatment weighting adjustment, the adjusted HR of Flu/Bu2 compared with Flu/Mel80–100 group for 5‐year OS was 0.77 (95% CI, 0.60–0.99, p = 0.046), 0.97 (95% CI, 0.78–1.21, p = 0.798) for 5‐year progression‐free survival, 0.65 (95% CI, 0.45–0.94, p = 0.022) for 5‐year cumulative risk of non‐relapse mortality and 1.25 (95% CI, 0.95–1.64, p = 0.115) for 5‐year cumulative risk of relapse. In this study, patients with NHL who received Flu/Bu2 were associated with better OS and lower non‐relapse mortality than those who received Flu/Mel80–100.
The carbon footprint of the perioperative transurethral resection of bladder tumour pathway
Authors: John Joseph B. , Collins Michael , Eames Sophie , O’Flynn Kieran , Briggs Tim W.R. , Gray William K. , McGrath John S. 
Published: July 2024

ObjectivesTo evaluate the carbon footprint of the perioperative transurethral resection of bladder tumour (TURBT) pathway from decision to treat to postoperative discharge, and model potential greenhouse gas (GHG) emissions reduction strategies.Materials and MethodsThis process‐based attributional cradle‐to‐grave life‐cycle assessment (LCA) of GHG emissions modelled the perioperative TURBT pathway at a hospital in Southwest England. We included travel, energy and water use, all reusable and consumable items, and laundry and equipment sterilisation. Resource use for 30 patients undergoing surgery was recorded to understand average GHG emissions and the inter‐case variability. Sensitivity analysis was performed for manufacturing location, pharmaceutical manufacturing carbon‐intensity, and theatre list utilisation.ResultsThe median (interquartile range) perioperative TURBT carbon footprint was 131.8 (119.8–153.6) kg of carbon dioxide equivalent. Major pathway categories contributing to GHG emissions were surgical equipment (22.2%), travel (18.6%), gas and electricity (13.3%), and anaesthesia/drugs and associated adjuncts (27.0%), primarily due to consumable items and processes. Readily modifiable GHG emissions hotspots included patient travel for preoperative assessment, glove use, catheter use, irrigation delivery and extraction, and mitomycin C disposal. GHG emissions were higher for those admitted as inpatients after surgery.ConclusionsThis cradle‐to‐grave LCA found multiple modifiable GHG emissions hotspots. Key mitigation themes include minimising avoidable patient travel, rationalising equipment use, optimally filling operating theatre lists, and safely avoiding postoperative catheterisation and hospital admission where possible. A crucial next step is to design and deliver an implementation strategy for the environmentally sustainable changes demonstrated herein.
Exploring virtual museums: Pre‐service teachers' experiences of virtual museums in gifted and talented education
Authors: Kahveci Nihat Gurel 
Published: July 2024

AbstractThis study aimed to explore prospective teachers' views and experiences of the utilization of virtual museums for gifted and talented education. The study was conducted at the College of Education of a large Western University in Turkey. The participants were prospective teachers (seniors at the undergraduate level) from the Department of Gifted and Talented Teacher Education, who were expected to become classroom teachers responsible for teaching a wide range of subjects, including reading, mathematics, science, and social studies. Ten prospective teachers voluntarily participated in the study. The study employed a qualitative phenomenological design. The research illuminated the ways in which participants perceived and understood these experiences. This study provided valuable insights into the potential use of virtual museums in the education of gifted students, general education, and teacher education, and considered the positive and negative experiences of pre‐service teachers who have visited virtual museums.
Quantitative analyses of distribution of the heart rot fungus Serpula himantioides in living Chamaecyparis pisifera using real‐time polymerase chain reaction
Authors: Haraguchi Ryusei , Hirao Toshihide , Yamada Toshihiro 
Published: July 2024

AbstractSerpula himantioides is a widely distributed wood rot fungus that causes heart rot in various tree species. In Japan, heart rot associated with S. himantioides occurs in Chamaecyparis pisifera; however, its distribution within living trees and changes in its abundance as decay progresses remain unclear. In this study, we used a real‐time polymerase chain reaction (real‐time PCR) assay to specifically detect and quantify S. himantioides in wood. This allowed us to determine the distribution of S. himantioides in living C. pisifera and to monitor changes in its abundance as decay progressed. In addition, the mode of decay progression was characterized using nonhierarchical clustering. Serpula himantioides was detected from both decayed and undecayed heartwood and at sites as high as 12 m in the trunk, suggesting that it was widely distributed in the heartwood. The clustering analysis grouped samples into three clusters corresponding to the incipient, intermediate and advanced stages of decay. The abundance of S. himantioides increased from the incipient stage to the intermediate stage of decay and decreased at the advanced stage. The results quantitatively showed that intermediate stage decay moved up the trunk and replaced the part corresponding to the incipient stage as decay progressed. These results will be useful for devising methods for the early detection of heart rot caused by S. himantioides and to understand the progress of decay caused by wood rot fungi in living trees.
Robustness assessment of an automated AI‐based white blood cell morphometric analysis system using different smear preparation methods
Authors: Ravzanaadii Mendamar , Horiuchi Yuki , Iwasaki Yosuke , Matsuzaki Akihiko , Kaniyu Kimiko , Bai Jing , Konishi Aya , Ando Jun , Ando Miki , Tabe Yoko 
Published: July 2024

AbstractIntroductionNumerous AI‐based systems are being developed to evaluate peripheral blood (PB) smears, but the feasibility of these systems on different smear preparation methods has not been fully understood. In this study, we assessed the impact of different smear preparation methods on the robustness of the deep learning system (DLS).MethodsWe collected 193 PB samples from patients, preparing a pair of smears for each sample using two systems: (1) SP50 smears, prepared by the DLS recommended fully automated slide preparation with double fan drying and staining (May–Grunwald Giemsa, M–G) system using SP50 (Sysmex) and (2) SP1000i smears, prepared by automated smear preparation with single fan drying by SP1000i (Sysmex) and manually stained with M–G. Digital images of PB cells were captured using DI‐60 (Sysmex), and the DLS performed cell classification. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were used to evaluate the performance of the DLS.ResultsThe specificity and NPV for all cell types were 97.4%–100% in both smear sets. The average sensitivity and PPV were 88.9% and 90.1% on SP50 smears, and 87.0% and 83.2% on SP1000i smears, respectively. The lower performance on SP1000i smears was attributed to the intra‐lineage misclassification of neutrophil precursors and inter‐lineage misclassification of lymphocytes.ConclusionThe DLS demonstrated consistent performance in specificity and NPV for smears prepared by a system different from the recommended method. Our results suggest that applying an automated smear preparation system optimized for the DLS system may be important.
Scale for the environments evaluation of professional nursing practice—shortened version: Psychometric evaluation
Authors: Ribeiro Olga Maria Pimenta Lopes , de Lima Trindade Letícia , da Rocha Carla Gomes , Teles Paulo João Figueiredo Cabral , Mendes Mariana , Ribeiro Marlene Patrícia , de Abreu Pereira Soraia Cristina , da Conceição Alves Faria Ana , da Silva João Miguel Almeida Ventura , de Sousa Clemente Neves 
Published: July 2024

AbstractAimThe aim of this study is to test the validity and reliability of the shortened version of the Scale for the Environments Evaluation of Professional Nursing Practice (SEE‐Nursing Practice).MethodsThis methodological, cross‐sectional study was conducted between September and December 2022. The original version of the SEE‐Nursing Practice was administered in questionnaire format across 17 hospitals. Exploratory and confirmatory factor analyses were conducted to identify relevant items for the new shortened version of the scale and evaluate its construct validity.ResultsThe study involved 1713 registered nurses from various regions of Portugal. From the exploratory factor analysis, the SEE‐Nursing Practice was condensed to 59 items and 3 subscales. In the structure subscale, 14 items were removed, and the remaining 29 items distributed over four factors; in the process subscale, 18 items were removed, and the remaining 19 items organized into three factors; in the outcome subscale, 2 items were removed, and the remaining 11 items distributed over two factors. The Cronbach's alpha for the three subscales exceeded 0.90, indicating high reliability. Confirmatory factor analyses provided support for the validity of the 59‐item model.ConclusionThe shortened version of the SEE‐Nursing Practice shows adequate validity and reliability, reducing the burden associated with its longer version.