bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pengaruh Pemberian Biji Labu Kuning Terhadap Peningkatan Kadar Hemoglobin
Authors: Cakrawati.R Cakrawati.R , Sumarni Sri , Sudiyono Sudiyono 
Published: July 2024

ABSTRACT Iron Deficiency Anemia is anemia caused by a lack of iron availability in the body. Hemoglobin is a protein found in human erythrocytes. Deficiency in hemoglobin levels is influenced by insufficient iron in the body and the iron metabolism process. Anemia is declared if the hemoglobin level is below normal levels. Nutrients that play an important role in the formation and function of hemoglobin are Iron, Protein, Vitamin C. Pumpkin seeds contain many nutrients that are beneficial for body health such as phytochemicals (phytosterols), vitamin C, vitamin E, beta-carotene and minerals (magnesium, selenium and zinc). Pumpkin seeds also contain fiber which inhibits cholesterol absorption in the intestine. Pumpkin seeds contain various important nutrients, including iron, zinc, magnesium, and omega-6 and omega-3 fats. This study aims to determine the effect of giving pumpkin seeds on increasing hemoglobin levels. Study of literature by collecting relevant literature using online journal data based on, Researchgate, Google Scholar, PubMed and Garuda identified in 2013 -2023. The results of the analysis showed that giving pumpkin seeds had an impact on increasing hemoglobin levels. Conclusion: Giving pumpkin seeds to teenagers, women of childbearing age and pregnant women can increase hemoglobin levels and prevent iron deficiency anemia. Keywords: Anemia, Pumpkin Seeds, Hemoglobin ABSTRAK Anemia Defisiensi Besi adalah anemia yang disebabkan oleh kurangnya ketersediaan zat besi dalam tubuh. Hemoglobin merupakan protein yang terdapat dalam eritrosit manusia, Kekurangan kadar hemoglobin dipengaruhi oleh tercukupinya zat besi dalam tubuh dan proses metabolisme besi. Dinyatakan anemia apabila kadar hemoglobin di bawah kadar normal. Zat gizi yang berperan penting dalam pembentukan dan fungsi hemoglobin yaitu Zat Besi, Protein, Vitamin C. Biji labu kuning mengandung banyak nutrisi yang bermanfaat bagi kesehatan tubuh seperti fitokimia (fitosterol), vitamin C, vitamin E, betakaroten dan mineral (magnesium, selenium dan zinc). Biji labu kuning juga mengandung serat yang menghambat penyerapan kolesterol di usus. Biji labu mengandung berbagai nutrisi penting, termasuk zat besi, seng, magnesium, serta lemak omega-6 dan omega-3. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian biji labu kuning terhadap peningkatan kadar hemoglobin. Studi literatur dengan mengumpulkan literatur yang relevan dengan menggunakan data jurnal online berdasarkan Researchgate, Google Scholar, PubMed and Garuda yang diidentifikasi tahun 2013 -2023. Hasil analisis menunjukkan bahwa pemberian biji labu kuning berdampak pada peningkatan kadar hemoglobin. Kesimpulan Pemberian biji labu kuning pada remaja, wanita usia subur dan ibu hamil dapat meningkatkan kadar hemoglobin dan dapat mencegah anemia defisiensi besi. Kata Kunci: Anemia, Biji Labu Kuning, Hemoglobin
Analisis Faktor-Faktor yang Mempengaruhi Kepatuhan Diet Pada Penderita Diabetes Mellitus Tipe 2
Authors: Sembiring Evi Christin Br , Christina Juliana , Rudhiati Fauziah , Erlina Lina , Badrujamaludin Asep 
Published: July 2024

ABSTRACT Dietary compliance is a critical element in the management of preventing complications of Type 2 Diabetes Mellitus. An appropriate diet helps control blood sugar levels, complications, and improves the quality of life of Type 2 Diabetes Mellitus sufferers. The aim of the research is to determine the factors that influence dietary compliance in controlling sugar levels blood in people with Type 2 Diabetes Mellitus. Correlation analytical research type with a cross-sectional approach. The total sample was 173. The instrument used was a questionnaire. The statistical analysis used in this research is Multiple Logistic Regression. The results of the bivariate test showed that the p value of the cultural variables was 0.001, lifestyle 0.004, motivation 0.001, knowledge 0.001, family support 0.004 and stress management 0.004. Multivariate tests showed a cultural p value of 0.001 (OR 13.230) and lifestyle of 0.001 (OR 5.841). Cultural variables, lifestyle, motivation, knowledge, family support and stress management have a significant effect on dietary compliance to control blood sugar levels in Type 2 Diabetes Mellitus sufferers. Meanwhile, the variables that have the most influence on dietary compliance are culture and lifestyle. Keywords: Culture, Family support, Dietary Compliance, Lifestyle ABSTRAK Kepatuhan diet merupakan elemen kritis dalam manajemen pencegahan komplikasi Diabetes Mellitus Tipe 2. Diet yang tepat membantu mengontrol kadar gula darah, komplikasi, dan meningkatkan kualitas hidup penderita Diabetes Mellitus Tipe 2. Tujuan penelitian untuk mengetahui faktor-faktor yang mempengaruhi kepatuhan diet dalam pengendalian kadar gula darah pada penderita Diabetes Mellitus Tipe 2. Jenis penelitian analitik korelasi dengan pendekatan cross-sectional. Jumlah sampel sebanyak 173. Instrumen yang digunakan yaitu kuisioner. Analisis statistik yang digunakan dalam penelitian ini yaitu Regresi Logistic Ganda. Hasil uji bivariat didapatkan bahwa p value variabel budaya 0,001, pola hidup 0,004, motivasi 0,001, pengetahuan 0,001, dukungan keluarga 0,004 dan pengelolaan stres 0,004. Uji multivariat didapatkan p value budaya 0,001 (OR 13,230) dan pola hidup 0,001 (OR 5,841). Variabel budaya, pola hidup, motivasi, pengetahuan, dukungan keluarga dan pengelolaan stres berpengaruh secara signifikan terhadap kepatuhan diet untuk mengendalikan kadar gula darah penderita Diabetes Mellitus Tipe 2. Sedangkan variabel yang paling berpengaruh terhadap kepatuhan diet yaitu budaya dan pola hidup Kata Kunci: Budaya, Dukungan Keluarga, Kepatuhan Diet, Pola Hidup
Evidence Based Practice Nursing : Pengaruh Pursed Lip Breathing Terhadap Saturasi Oksigen Pada Pasien Penyakit Paru Obstruktif Kronis di Instalasi Gawat Darurat RSUD Ir. Soekarno Sukoharjo
Authors: Isa Zainuddin S. , Hudiyawati Dian , Haryanto Agung 
Published: July 2024

ABSTRACT Chronic obstructive pulmonary disease (COPD) is a disease characterized by persistent respiratory symptoms and airflow limitations caused by respiratory and/or alveolar abnormalities, usually caused by exposure to harmful particles or gases. This study aims to determine the effect of giving pursed lip breathing on increasing oxygen saturation in COPD patients in the emergency room of the IR Hospital. Soekarno Sukoharjo Hospital. This study used the application of evidance based nursing practice with a one group pre test and post test design in one intervention group, where the research subjects are 6 COPD patients whose oxygen saturation is low in the emergency room of the Ir. Soekarno Sukoharjo Hospital. Patients were given intervention for ± 7-10 minutes while in the emergency room. The results obtained by performing non-pharmacological therapy in the form of pursed lip breathing techniques 1 time at a time. the results of measuring oxygen saturation have improved after nursing action and evaluation is carried out with documentation based on subject, objective, analysis and planning. Conclusion pursed lip braething breathing technique therapy can improve oxygen saturation in COPD patients. Keywords: Pursed Lip Breathing, oxygen saturation, COPD ABSTRAK Penyakit paru obstruktif kronis (PPOK) adalah penyakit yang ditandai dengan gejala pernafasan yang persisten dan keterbatasan aliran udara disebabkan oleh kelainan pernafasan dan/atau alveolar, biasanya disebabkan oleh paparan partikel atau gas berbahaya. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian pursed lip breathing terhadap peningkatan saturasi oksigen pada pasien PPOK di ruang IGD RSUD IR. Soekarno Sukoharjo. Penelitian ini menggunakan penerapan evidance based nursing pcactice dengan bentuk desain one grup pre test dan post test pada satu kelompok intervensi, dimana subjek penelitiannya adalah 6 pasien PPOK yang saturasi oksigennya rendah di ruang IGD RSUD Ir. Soekarno Sukoharjo. Pasien diberikan intervensi selama ±7-10 menit pada saat di ruang IGD. Hasil yang di dapat dengan melakukan terapi non farmakologi berupa teknik pernafasan pursed lip breathing sebanyak 1 kali dalam 1 waktu. hasil pengukuran saturassi oksigen mengalami perbaikan setelah dilakukan tindakan keperawatan dan dilakukan evaluasi dengan pendokumentasian berdasarkan subjek, objektif, analisa dan perencanaan. Kesimpulan terapi teknik pernapasan pursed lip braething dapat meningkatkan saturasi oksigen pada pasien PPOK. Kata Kunci: Pursed Lips Breating, Saturasi Oksigen, PPOK
Hubungan Komunikasi Terapeutik dengan Kecemasan Pasien Pre Opeasai Apendisitis : Systematic Literature Review
Authors: Luginasari Yulia , Faozi Akhmad , Rahmat Delli Yuliana 
Published: July 2024

ABSTRACT Appendicitis is a common inflammatory bowel disease that sometimes requires surgical intervention. The surgery for appendicitis is called an appendectomy. The surgical procedure for appendicitis can cause anxiety in patients, and one way to manage this anxiety is through therapeutic communication. Therapeutic communication is conducted by nurses with patients with the aim of promoting the patient's recovery. The objective of this study is to determine the relationship between therapeutic communication by nurses and preoperative anxiety in appendicitis patients. The method used in this study is a literature review using databases such as Google Scholar and ScienceDirect, including articles in both English and Indonesian. A total of 5 relevant articles were selected for review. The results of this study indicate that there is a relationship between therapeutic communication and preoperative anxiety in appendicitis patients. Therapeutic communication conducted by nurses has a positive impact on preoperative patients because it fosters trust and increases knowledge, thereby reducing patient anxiety. Keywords: Therapeutic Communication, Anxiety Level, Pre Operative, Apendisitis ABSTRAK Apendisitis adalah radang usus yang umum dan sering memerlukan operasi. Apendektomi adalah operasi yang dilakukan untuk mengobati apendisitis. Pasien dapat mengalami kecemasan karena prosedur operasi ini. Salah satu cara untuk mengurangi kecemasan adalah dengan berbicara dengan orang lain secara terapeutik. Interaksi yang dilakukan untuk membantu pasien sembuh disebut komunikasi terapeutik. Tujuan dari penelitian ini adalah untuk mengetahui apakah ada hubungan antara komunikasi terapeutik yang dilakukan oleh perawat dan tingkat kecemasan pasien sebelum operasi apendisitis. Metode penelitian ini menggunakan database dalam bahasa Inggris dan Indonesia seperti Google Scholar dan Sciencedirect untuk melakukan tinjauan literatur, yang menghasilkan lima artikel yang relevan. Hasil penelitian menunjukkan bahwa komunikasi terapeutik dan kecemasan pasien sebelum operasi apendisitis berkorelasi. Pasien praoperasi mendapat manfaat dari komunikasi terapeutik perawat karena meningkatkan kepercayaan mereka dan meningkatkan pengetahuan mereka, sehingga mengurangikecemasan pasien. Kata Kunci: Komunikasi Terapeutik, Kecemasan, Pre Operasi, Apendisitis
Uji Validitas dan Reliabilitas Instrumen Penelitian Pengaruh Kepemilikan Apotek Terhadap Pelaksanaan Pelayanan Konseling dan Pelayanan Informasi Obat Oleh Apoteker
Authors: Manurung Deny , Rahem Abdul , Priyandani Yuni 
Published: July 2024

ABSTRACT Counselling and Drug Information Services (PIO) is one of the pharmaceutical services that involves interaction between pharmacists and patients to meet the "needs and wants" of patients so that the treatment provided is effective. One of the factors related to the quality of pharmaceutical services is pharmacy ownership. A research instrument is needed, namely a valid and reliable questionnaire to measure the effect of pharmacy ownership on the implementation of counselling and PIO by pharmacists. This study aims to measure the validity and reliability of the questionnaire for the implementation of counselling and PIO by pharmacists. This study used a crossectional method. The sample size was 30 respondents, namely pharmacists in charge of pharmacies in the Surabaya area. The results of the validity test of the counselling and PIO questionnaire showed that 18 and 19 questions were valid with a value of r count> r table. The results of the reliability test, the Cronbach's Alpha value of the counselling and PIO questionnaires were 0.898 and 0.896> 0.6. Based on the results of the discussion, it can be concluded that the questionnaire can be declared valid and reliable. Keywords: Counselling, Drug Information Services (PIO), Pharmacy Ownership, Validity, Reliability ABSTRAK Konseling dan Pelayanan Informasi Obat (PIO) merupakan salah satu pelayanan kefarmasian yang melibatkan interaksi antara apoteker dan pasien untuk memenuhi “need and want” pasien supaya pengobatan yang diberikan efektif. Faktor yang berhubungan dengan kualitas pelayanan kefarmasian salah satunya adalah kepemilkan apotek. Diperlukan intrumen penelitian yaitu kuesioner valid dan reliabel untuk mengukur pengaruh kepemilikan apotek terhadap pelaksanaan konseling dan PIO oleh apoteker. Penelitian ini bertujuan untuk mengukur validitas dan realibilitas kuesioner pelaksanaan konseling dan PIO oleh apoteker. Penelitian ini menggunakan metode crossectional. Jumlah sampel 30 responden yaitu apoteker penanggung jawab di apotek wilayah Surabaya. Hasil uji validitas kuesioner konseling dan PIO menunjukkan bahwa 18 dan 19 pertanyaan valid dengan nilai r hitung > r tabel. Hasil uji realibilitas, nilai Cronbach’s Alpha kuesioner konseling dan PIO adalah 0.898 dan 0.896 > 0.6. Berdasarkan hasil pembahasan dapat disimpulkan bahwa kuesioner dapat dinyatakan valid dan reliabel. Kata Kunci: Konseling, Pelayanan Informasi Obat (PIO), Kepemilikan Apotek,Validitas, Reliabilitas
An Update review on Childhood Interstitial Lung Diseases (chILD)
Authors: Habib Rahat Bin , Kabir ARM Luthful 
Published: July 2024

In recent times, we have encountered several cases of childhood Interstitial Lung Disease (chILD) in our clinical practice in Bangladesh. In developed world, there has been tremendous progress in the approach to chILD, with particular recognition that chILD in infants is often distinct from the forms that occur in older children and adults. Confirmation of diagnosis is challenging because of the rarity of ILD and the fact that the presenting symptoms of ILD often overlap those of common respiratory disorders. There are few case reports and almost no study on chILD in Bangladesh from net search. A growing part of the etiologic spectrum of chILD is being attributed to molecular defects. The pathogenesis of the various chILD is complex and the diseases share common features of inflammatory and fibrotic changes of the lung parenchyma that impair gas exchanges. We are trying to diagnose chILD by excluding methods of suspected children in our aspects. However, in developed nations, clinical practice guidelines emphasize the role for high resolution computed tomography (HRCT) of chest, genetic testing, and lung biopsy in the diagnostic evaluation. Despite improvements in patient management, the therapeutic strategies are still relying mostly on corticosteroids although specific therapies are emerging. Larger longitudinal cohorts of patients are being gathered through ongoing international collaborations to improve disease knowledge and targeted therapies. Thus, it is expected that children with ILD will be able to reach the adulthood transition in a better condition.
Bangladesh Med J. 2023 May; 52(2): 40-46
Serum Vitamin D Level in Inflammatory Bowel Disease (IBD) and it’s Association with IBD Activity Abstract
Authors: Miah Md Shah Alam , Chowdhury Md Fazlul Karim , Islam Susmita , Newaz Abdullah Al Shah , Akter Dilruba , Saha Tanmoy , Akhter Md Tuhin , Adikhary Debprosad , Saha Kirshna Pada , Ghosh Chanchal Kumar , Razib Kh Olinur 
Published: July 2024

Vitamin D influences innate immunity, which is believed to be the imbalance of it involved in the pathogenesis of Inflammatory Bowel Disease (IBD). Evidence exists on the association between vitamin D deficiency and inflammatory bowel disease (IBD). To assess the serum vitamin D concentration in patients with inflammatory bowel disease and to study the relationship of vitamin D level with disease activity in the patients with inflammatory bowel disease. This case-control study was carried out in the department of Gastroenterology, Bangabandhu Sheikh Mujib Medical University (BSMMU) on 40 IBD cases, diagnosed on clinical background and 40 apparently healthy control group of similar age and sex. Blood samples were collected and serum vitamin D level was measured with Chemiluminescent Microparticle Immunoassay (CMIA) method in Biochemistry laboratory of BSMMU. The result were analyzed by SPSS version 22. Vitamin D deficiency and insufficiency were defined as serum concentration of ≤20 ng/ml and 21–29 ng/ml respectively. Disease activity were evaluated using the Harvey Bradshaw Index for Crohn’s Disease, Truelove and Witt’s Index for Ulcerative colitis. The vitamin D levels were correlated with disease activity in IBD patients comparing with control group. Mean (±SD) serum vitamin D levels were 16.27 ± 5.16 ng/ml in IBD group and 24.25 ± 6.69 in controls (p <0.001). Almost all (97 %) of IBD patients had low serum vitamin D in comparison to controls; more than three-fourth (77.5%) of the patients of IBD exhibited deficiency (˂20 ng/ml), one-fifth (20%) had insufficiency (21-29 ng/ml) of serum vitamin D, whereas in the controls 30% had deficiency, 42.5% had insufficiency, and 27.5% had sufficient serum vitamin D. There was highly significant inverse correlation between vitamin D level and disease activity in IBD patients. The study showed that IBD patients had significantly lower serum vitamin D levels in comparison to controls. Serum vitamin D concentration is inversely correlated with disease activity in IBD patients. The study suggests that inadequate vitamin D level, along with other factors, probably contributes to the development of active disease in patients with IBD.
Bangladesh Med J. 2023 May; 52(2): 20-28
Generative Artificial Intelligence in Education and its Governance: Perspective of Copyright Law
Authors: Mayana Ranti Fauza , Santika Tisni 
Published: July 2024

As a domain of science and technology, Artificial Intelligence (AI) opened new horizons for education. Technologies change the ways we teach and learn. While Generative AI tools create new prospects for learning, several concerns also arise. Educators are worried that they cannot differentiate between the output of students' work and the output from AI and this will impact the discipline, originality, integrity, and ethics in such cases. In addition, the problem also potentially arises in the matter of the authorship of the works regarding Copyright Law. This paper examines several legal issues of the utilization of Generative AI through the perspective of Copyright Law. This paper concludes several important points; First, although the framework of Indonesia’s copyright law is based on the principle of human authorship, the rapid development of Generative AI must be balanced with an accommodative legal framework, Second, it is particularly important to formulate a special provisions to guide the implementation concerning the utilization of copyrighted works as the input material for generative AI so that it will not harm the "legitimate interest of the author" in the limit of "normal exploitation of the work" and classified as fair use, Third, academics and administrators need to gain a better understanding of the promise and perils of generative AI, how it will likely impact education, and how it might best govern by encourage the school and universities to develop institutional policies and/or formal guidance concerning the use of digital technology and Generative AI for the future of education.
Tad pili contribute to the virulence and biofilm formation of virulent Aeromonas hydrophila
Authors: Tekedar Hasan C. , Patel Fenny , Blom Jochen , Griffin Matt J. , Waldbieser Geoffrey C. , Kumru Salih , Abdelhamed Hossam , Dharan Vandana , Hanson Larry A. , Lawrence Mark L. 
Published: July 2024

Type IV pili (T4P) are versatile proteinaceous protrusions that mediate diverse bacterial processes, including adhesion, motility, and biofilm formation. Aeromonas hydrophila, a Gram-negative facultative anaerobe, causes disease in a wide range of hosts. Previously, we reported the presence of a unique Type IV class C pilus, known as tight adherence (Tad), in virulent Aeromonas hydrophila (vAh). In the present study, we sought to functionalize the role of Tad pili in the pathogenicity of A. hydrophila ML09-119. Through a comprehensive comparative genomics analysis of 170 A. hydrophila genomes, the conserved presence of the Tad operon in vAh isolates was confirmed, suggesting its potential contribution to pathogenicity. Herein, the entire Tad operon was knocked out from A. hydrophila ML09-119 to elucidate its specific role in A. hydrophila virulence. The absence of the Tad operon did not affect growth kinetics but significantly reduced virulence in catfish fingerlings, highlighting the essential role of the Tad operon during infection. Biofilm formation of A. hydrophila ML09-119 was significantly decreased in the Tad operon deletant. Absence of the Tad operon had no effect on sensitivity to other environmental stressors, including hydrogen peroxide, osmolarity, alkalinity, and temperature; however, it was more sensitive to low pH conditions. Scanning electron microscopy revealed that the Tad mutant had a rougher surface structure during log phase growth than the wildtype strain, indicating the absence of Tad impacts the outer surface of vAh during cell division, of which the biological consequences are unknown. These findings highlight the role of Tad in vAh pathogenesis and biofilm formation, signifying the importance of T4P in bacterial infections.
Factors influencing accelerated aging in patients with type 2 diabetes mellitus and coronary heart disease
Authors: Huang Zehua , Liu Nana , Chen Shiyi , Chen Zhiren , Wang Peian 
Published: July 2024

ObjectiveTo investigate the factors influencing accelerated aging in patients with type 2 diabetes mellitus (T2DM) and coronary heart disease (CHD).MethodsA total of 216 patients diagnosed with T2DM and CHD between August 2019 and August 2023 at Xuzhou Central Hospital were selected. Patients were divided into an aging group and a non-aging group, based on the positive or negative values of phenotypic age acceleration (PhenoAgeAccel). Logistic regression analysis was conducted. Variables that had a univariate analysis P&lt; 0.05 were included in the multivariate analysis to identify factors influencing aging in patients with T2DM and CHD, and the area under the curve of the model was reported.ResultsThis study included 216 patients, with 89 in the accelerated aging group, and 127 in the non-accelerated aging group. The average age of patients was 70.40 (95% CI: 69.10-71.69) years, with 137 males (63.4%). Compared with the non-accelerated aging group, patients in the accelerated aging group were older, with a higher proportion of males, and a higher prevalence of hypertension, stable angina pectoris, and unstable angina pectoris. Multivariate Logistic regression analysis indicated that the absolute value of neutrophils (NEUT#), urea (UREA), adenosine deaminase (ADA), and the triglyceride-glucose index (TyG) were risk factors for accelerated aging, while cholinesterase (CHE) was a protective factor. For each unit increase in NEUT#, UREA, ADA, and TyG, the risk of aging increased by 64%, 48%, 10%, and 789%, respectively. The overall area under the receiver operating characteristic (ROC) curve of the model in the training set was 0.894, with a 95% confidence interval (CI) of 0.851-0.938.ConclusionNEUT#, CHE, UREA, ADA, and TyG are predictors of accelerated aging in patients with T2DM and CHD, with the model showing favorable overall predictive performance.