bluuebunny/crossref_metadata_2025_split huggingface dataset:
X- vs. O-marked want
Authors: Wimmer Alexander 
Published: August 2024

Abstract
X-marked want is identified by von Fintel & Iatridou (2023) (vF&I) as one of the crosslinguistic challenges for what they call X-marking, the kind of morphology traditionally referred to as ‘subjunctive’ or ‘counterfactual’. This paper’s main goal is to spell out vF&I’s idea that X-marking on want reflects a widening of want’s quantificational domain, thereby doing the same job as it does in conditionals under an influential view originating with Stalnaker (1975). With Sode (2021), but also Grano & Phillips-Brown (2022), the proposition $\phi $ denoted by want’s complement is treated as the antecedent of a “hidden conditional” that Heim (1992) sees in want and desire-ascriptions more generally, a treatment in whose favor vF&I’s Conditional/Desire Pattern provides morphosyntactic evidence. In line with the Stalnakerian view, but also more recent ones under which X-marking is semantically vacuous (Crowley 2022; Leahy 2011, 2018), X-marking on want is treated as reflecting the absence of a presuppositional constraint that the O-marked counterpart comes with: a limitation of closest antecedent-worlds to the attitude holder’s belief set.
An adaptive functional regression framework for locally heterogeneous signals in spectroscopy
Authors: Ferraccioli Federico , Casa Alessandro , Stefanucci Marco 
Published: August 2024

Abstract
In recent years, there has been growing attention towards food nutritional properties, traceability, and production systems prioritizing environmental sustainability. Consequently, there is a rising demand for tools evaluating food quality and authenticity, with mid-infrared (MIR) spectroscopy techniques playing a pivotal role to collect vast amounts of data. These data pose some challenges that existing methods struggle to address, thus necessitating the development of new statistical techniques. We introduce an adaptive functional regression framework allowing for the definition of a flexible estimator accommodating different degrees of smoothness. We provide an optimization procedure handling both Gaussian and non-Gaussian responses, and allowing for the inclusion of scalar covariates. Our proposal is applied to MIR spectroscopy data, providing excellent performances when predicting milk composition and cows’ dietary regimens. Furthermore, the developed inferential routine enhances the interpretability of the results, providing valuable insights leading to a deeper understanding of the relation between specific wavenumbers and milk characteristics.
A case series of upper extremity reconstructions utilizing partial ECRB and ECRL tendon autografts
Authors: Haddad David , Kempton Darren , Ghotmi Joey , Türker Tolga 
Published: August 2024

Abstract
Sources of autografts such as palmaris longus or plantaris are often limited or absent. We present our experience using a low donor-site morbidity method of harvesting strips of extensor carpi radialis brevis and longus (ECRB and ECRL) as free tendon autografts in upper extremity soft tissue reconstructions. Retrospective chart review identified five patients who received reconstructive upper extremity surgeries using ECRB and ECRL partial tendon autografts from January 2014 to October 2021 with at least a 12-month follow-up period. Mayo wrist scores were calculated to demonstrate clinical outcomes. All five patients (mean follow-up: 21 months) were able to return to regular activities while demonstrating improvements in 6- and 12-month postoperative Mayo wrist scores. There was minimal donor site morbidity and no ruptures of parent tendons following harvest. This study provides additional support for utilizing partial strips of ECRB and ECRL in repairing upper extremity tendon gap and ligament deformities.
Generation of high purity capsanthin and capsorubin through synthetic metabolic engineering in carrot germplasm
Authors: Deng Yuan-Jie , Duan Ao-Qi , Liu Hui , Xu Zhi-Sheng , Xiong Ai-Sheng 
Published: August 2024

Abstract
Capsanthin and capsorubin are red κ-xanthophylls exclusively found in a handful of other plant species. Currently, capsanthin and capsorubin are extracted from red pepper (Capsicum annuum L.). Here, high purity production of capsanthin and capsorubin was achieved in carrot (Daucus carota L.) taproot by a synthetic metabolic engineering strategy. Expression of a capsanthin-capsorubin synthase gene (CaCCS) from pepper resulted in dominant production of capsanthin, whereas expression of a LiCCS gene from tiger lily (Lilium lancifolium Thunb.) resulted in production of both capsanthin and capsorubin in carrot taproot. The highest content of capsanthin and capsorubin was obtained in LiC-1 carrot taproot hosting the LiCCS gene. Co-expression of DcBCH1 with CCS could improve the purity of capsanthin and capsorubin by eliminating the non-target carotenoids (e.g. α-carotene and β-carotene). The highest purity of capsanthin and capsorubin was obtained in BLiC-1 carrot taproot hosting DcBCH1+LiCCS genes, 91.10% of total carotenoids. The non-native pigments were esterified partially and stored in the globular chromoplast of carrot taproot. Our results demonstrated the use of carrot taproot as green factories for high purity production of capsanthin and capsorubin. The capsanthin/capsorubin carrot germplasms are also valuable materials for breeding colorful carrots cultivars.
Aspergillosis coinfection in patients with proven mucormycosis
Authors: Ra Sang Hyun , Kim Ji Yeun , Song Joon Seon , Jang Hyeon Mu , Chang Euijin , Bae Seongman , Jung Jiwon , Kim Min Jae , Chong Yong Pil , Lee Sang-Oh , Choi Sang-Ho , Kim Yang Soo , Kim Sung-Han 
Published: August 2024

AbstractAlthough research on aspergillosis and mucormycosis confection is important to optimize antifungal therapy, data on this issue is scarce. Thus, we systematically investigated aspergillosis coinfection in patients with proven mucormycosis. Medical records of adult patients with proven mucormycosis whose formalin-fixed paraffin-embedded (FFPE) tissue sections were available, in a tertiary hospital from August 2007 to July 2023 were retrospectively reviewed to assess coinfection with aspergillosis. We noted cultures of fungi from sterile and non-sterile sites and performed polymerase chain reaction (PCR) assays on FFPE tissues to detect Aspergillus- and Mucorales-specific DNA. Sixty-seven patients with proven mucormycosis, including 12 (18%) with a positive culture of the mucormycosis agent from sterile site cultures, were enrolled. Fungal cultures from sterile and non-sterile sites revealed Aspergillus spp. growth in nine (13%) of the 67 patients, including two sterile and seven non-sterile cultures. The fungal PCR analysis from the FFPE sections was positive for Aspergillus-specific PCR in five (7%) and positive for both Aspergillus- and Mucorales-specific PCR results in eight (12%). Overall, 21 (31%) of the 67 patients with proven mucormycosis had microbiologic and/or molecular evidence of aspergillosis coinfection. Positive blood or bronchoalveolar lavage fluid galactomannan results were more common in the coinfection group (67% [14/21]) than in the mucormycosis group (37% [17/46], P = .024). No significant difference in mortality between the two groups was observed. Approximately one-third of patients with proven mucormycosis exhibited molecular and/or microbiologic evidence of aspergillosis coinfection. Further research is needed to identify patients with aspergillosis and mucormycosis coinfections, for optimal antifungal therapy.
Correlations of methyl formate (CH3OCHO), dimethyl ether (CH3OCH3), and ketene (H2CCO) in high-mass star-forming regions
Authors: Li Chuanshou , Qin Sheng-Li , Liu Tie , Liu Sheng-Yuan , Tang Mengyao , Liu Hong-Li , Chen Li , Li Xiaohu , Xu Fengwei , Zhang Tianwei , Liu Meizhu , Shi Hongqiong , Wu Yuefang 
Published: August 2024

ABSTRACT
We present high-spatial resolution (0.7–1.0 arcsec) submillimeter observations of continuum and molecular lines of CH$_{3}$OCHO, CH$_{3}$OCH$_{3}$, and H$_{2}$CCO toward 11 high-mass star-forming regions using the Atacama large millimetre/submillimetre array (ALMA). A total of 19 separate cores from nine high-mass star-forming regions are found to be line-rich, including high-, intermediate-, and low-mass line-rich cores. The three molecules are detected in these line-rich cores. We map the emission of CH$_{3}$OCHO, CH$_{3}$OCH$_{3}$, and H$_{2}$CCO in nine high-mass star-forming regions. The spatial distribution of the three molecules is very similar and concentrated in the areas of intense continuum emission. We also calculate the rotation temperatures, column densities, and abundances of CH$_{3}$OCHO, CH$_{3}$OCH$_{3}$, and H$_{2}$CCO under the local thermodynamic equilibrium assumption. The abundances relative to H$_{2}$ and CH$_{3}$OH, and line widths of the three molecules are significantly correlated. The abundances relative to H$_{2}$, temperatures, and line widths of the three molecules tend to be higher in cores with higher mass and outflows detected. The possible chemical links of the three molecules are discussed.
Changing of the guard: the delicate jurisdiction of trustee removal and the balance of power
Authors: Henson Jessica , Dowley Clementine 
Published: August 2024

Abstract
In this article, Jessica Henson and Clementine Dowley of Payne Hicks Beach LLP consider recent developments in the jurisdiction of trustee removal. Noting the multiplicity of ways in which a trustee’s office can be challenged, the ever-present threat of costs sanctions and the potential for removal to be used to thwart a trustee’s discretion, the authors reflect on the value of consistent trusteeship and whether, in that context, there is a risk that trustee removals (whether forced or voluntary) are being effected too easily.
A Case Series of Primary Cutaneous Sarcomatoid Carcinoma With Aberrant Smooth Muscle Actin Expression: A Clinicopathologic and Immunophenotypic Study
Authors: Shafi Saba , Gru Alejandro A. , Roman Jorge , Maupin Jessica , Plaza Jose A. 
Published: August 2024

Abstract:
Primary cutaneous sarcomatoid squamous cell carcinoma can show significant histologic overlap with other malignant spindle cell tumors, posing a diagnostic challenge. Even with a wide array of immunohistochemical markers, the exact line of differentiation can be a challenge to identify in some cases. The picture is further complicated by the aberrant expression of myofibroblastic markers [such as smooth muscle actin (SMA)] by these neoplasms, along with a concomitant loss of conventional epithelial markers. The histologic differential diagnoses of primary cutaneous sarcomatoid squamous cell carcinoma include desmoplastic melanoma, leiomyosarcoma, and spindle cell atypical fibroxanthoma/pleomorphic dermal sarcoma (AFX/PDS). A retrospective analysis of 16 cases of PCSSCCs with SMA expression, obtained from large academic institutions, was performed and is summarized below. The tumors were in the scalp (6 cases), arm (4 cases), leg (2 cases), face (2 cases), hand (1 case), and neck (1 case). Immunohistochemical studies were performed in all cases with the following antibodies: AE1/AE3, CAM 5.2, MNF-116, p63, p40, CK5/6, S-100, SOX10, SMA, desmin, calponin, H-caldesmon, CD10, CD68, CD163, and CD34. Histopathologically, all cases were classified as high-grade malignant poorly differentiated neoplasms. Tumors were characterized by an infiltrative neoplasm that involved the entire reticular dermis and, in 7 cases, the subcutaneous fat. Three cases were associated with a well-differentiated squamous cell component. The neoplasms were composed of atypical spindle and epithelioid cells arranged in long and intersecting fascicles. All neoplasms were positive for epithelial markers (at least 1 marker), and all cases were strongly positive for SMA. Our data emphasize the diagnostic utility of multiple epithelial markers as a first screening tool in the detection and workup of malignant cutaneous sarcomatoid neoplasms. Awareness of SMA expression in these tumors can complicate its diagnosis, and it is important to recognize this aberrant immunophenotype to facilitate definitive diagnosis and avoid misdiagnosis.
Effects of Social Isolation and Loneliness on Heart Failure Self-care
Authors: Platz Katherine , Cavanagh Casey E. , Metzger Maureen , Park Linda G. , Howie-Esquivel Jill 
Published: August 2024

Background
Patients with heart failure (HF) who engage in effective HF self-care have better quality of life, and lower risks of all-cause and HF-related hospital readmission and mortality. It is unclear whether social isolation and loneliness, which are prevalent among patients with HF and known to affect other self-care behaviors, can predict HF self-care.

Objective
The aim was to explore the relationship between social isolation, loneliness, and HF self-care.

Methods
This was a cross-sectional secondary analysis (n = 49) of the GEtting iNTo Light Exercise for HF randomized controlled trial, a 6-month home-based live group gentle exercise intervention for patients with HF. Measures included the following: 6-item Lubben Social Network Scale for social isolation, Patient-Reported Outcomes Measurement Information System Social Isolation survey for loneliness, Self-Care of Heart Failure Index, and Patient-Reported Outcomes Measurement Information System Depression survey. Multiple linear regression modeling was used to examine the relationships of 4 HF self-care processes to social isolation and loneliness, adjusting for depression and grouping (control group or intervention group).

Results
Scores indicating less social isolation predicted higher self-care maintenance (B = 0.937, P = .015), monitoring (B = 0.799, P = .041), and management (B = 1.812, P < .001). Loneliness did not predict HF self-care.

Conclusions
To our knowledge, this is the first study to predict HF self-care using distinct measures for social isolation and loneliness. Patients who were less socially isolated engaged in better HF self-care; loneliness had no relationship with HF self-care. Prospective studies are needed to investigate causal relationships between social isolation and HF-self-care engagement to determine the effect on outcomes such as hospital readmission and mortality.
Results of Laser-assisted Closure (SiLaC) Surgery in Pilonidal Sinus Disease: Factors Associated With Success
Authors: Yildirim Murat , Koca Bulent 
Published: August 2024

Background:
Pilonidal sinus treatment with sinus laser-assisted closure (SiLaC) method has produced promising results in a limited number of studies conducted in recent years. We aimed to examine the efficacy and safety of this method in a tertiary care training hospital to reveal the factors affecting failure and to share our first experiences.

Methods:
All adult patients treated with this procedure between March 2020 and December 2023 were included in the study. Demographic and clinical data, complications, and recurrence rates of the patients were compared. Univariate analysis was performed between recovered and non-recovered patients to find the factors influencing successful treatment. Logistic regression analysis was performed using significant factors in the single variable analysis.

Results:
The study cohort consisted of 64 patients. The mean follow-up period was 17.0±8.06 months (range: 3 to 36), and the mean time for return to work was 2.4±2.78 days (range: 0 to 14). Our recovery rate was 85.9%. The complication rate was 14%, and the majority (50%) were wound infections. High BMI and advanced disease were significant factors for recurrence in the comparison of patients with successful and unsuccessful treatment (P<0.01 and 0.013, respectively). The same situation persisted in multivariate analysis (P=0.026, 95% CI: 1.36-7.81, and P=0.004, 95% CI: 1.36-1.78, respectively). In the ROC Curve analysis for BMI, the cutoff point was 29 (sensitivity: 66.9%, specificity: 77.4%, AUC 0.809). Other parameters were not significant (P>0.05).

Conclusions:
The SiLaC procedure may be the treatment of choice for pilonidal sinus disease as a safe and effective method with mild complications and reasonable recurrence rates. The success rate decreased in obese patients and patients with advanced disease.
Documented transboundary transmission of mpox between the Central African Republic and the Democratic Republic of the Congo
Authors: Hasivirwe Vakaniaki Emmanuel , Kinganda-Lusamaki Eddy , Merritt Sydney , Kasongo Francois , Malembi Emile , Lunyanga Lygie , Linsuke Sylvie , Halbrook Megan , Kalthan Ernest , Pukuta Elisabeth , Amuri Aziza Adrienne , Makangara Cigolo Jean Claude , Lumembe Raphael , Kabamba Gabriel , Anta Yvon , Bolunza Pierrot , Kanda Innocent , Nganzobo Raoul , Kalonji Thierry , Nsio Justus , Matoka Patricia , Mwamba Dieudonné , Ngandu Christian , Shaw Souradet Y. , Shongo Robert , Madinga Joule , Boum Yap , Liesenborghs Laurens , Delaporte Eric , Ayouba Ahidjo , Low Nicola , Ahuka Mundeke Steve , Hensley Lisa E. , Muyembe Tamfum Jean-Jacques , Nakoune Emmanuel , Peeters Martine , Hoff Nicole A. , Kindrachuk Jason , Rimoin Anne W. , Mbala-Kingebeni Placide 
Published: August 2024

ABSTRACTFour confirmed mpox cases in South Ubangi province, Democratic Republic of the Congo, were linked to documented transboundary transmission from Central African Republic. Viral genome sequencing shows that the MPXV sequences belong to subclade Ia. This demonstrates the borderless nature of mpox and highlights the need for vigilant regional surveillance.
Improving prenatal detection of congenital heart disease with a scalable composite analysis of six fetal cardiac ultrasound biometrics
Authors: Reddy Aneela , Rizvi Sara , Moon-Grady Anita J. , Arnaout Rima 
Published: August 2024

ABSTRACTAlthough screening of prenatal congenital heart disease (CHD) has improved over the last decade, the diagnosis rate can still be as low as 40%. The axial 4 chamber (A4C) is the most reliably obtained cardiac view in the fetal screening ultrasound but alone only has a maximum clinical sensitivity of 50-60%, particularly in large multicenter studies in low-risk populations. Standard biometrics, like cardiac axis (CA), cardiothoracic ratio (CTR) and cardiac chamber fractional area change (FAC), have individually been shown to be useful for CHD screening and can all be obtained from A4C alone. However, these biometrics are vastly underutilized because they are time-consuming to extract and difficult to interpret all at once. We hypothesized that using six standard biometrics in combination can improve complex CHD screening versus any one biometric alone. K-means clustering was performed to segregate the patterns of heart measurements into clusters. Sensitivity and specificity for CHD was 87% and 75%, respectively. Here, we demonstrate that a composite of six standard biometric has better sensitivity and accuracy for CHD than any one biometric alone and better than A4C visual assessment.
Comparative Analysis of Adverse Event Reporting on Reddit and the FDA Adverse Event Reporting System (FAERS)
Authors: Shoults Catherine C. , Abulez Dana , Nowak Matthew , Bledsoe Alasiah , Dormer Nathan , Garza Maryam Y. , Bona Jonathan , Powell Thomas , Hayes Corey J. 
Published: August 2024

AbstractThis study explores the potential of Reddit as a pharmacovigilance data source by comparing its adverse event reports related to mental health drugs with those from the FDA Adverse Event Reporting System (FAERS). Using data mining techniques, we annotated 1,000 Reddit posts to identify drug-adverse event pairs, which were then compared to FAERS data. Significant differences were noted in the frequency and types of adverse events reported on each platform. For instance, Reddit showed higher reports of sexual dysfunction and cognitive disorders for certain drugs, which were less frequently reported in FAERS. This disparity suggests that Reddit could capture a different demographic or more candid discussions, potentially influenced by its pseudonymous nature. The findings indicate that social media platforms like Reddit can provide valuable insights into real-world drug effects, complementing traditional pharmacovigilance systems. This study highlights the need for further research to integrate social media data to enhance drug safety monitoring.
Time to death and its predictors among neonates with perinatal asphyxia at a tertiary hospital in southern Ethiopia
Authors: Bekele Jenenu Getu , Kara Niguse Mekonnen , Kerbo Amene Abebe , Urkashe Tadiwos Utalo 
Published: August 2024

AbstractBackgroundPerinatal asphyxia (PNA) remains a leading, yet preventable, cause of neonatal death, disproportionately affecting low-resource settings like Ethiopia. Despite its significance, data on the burden and factors influencing survival among asphyxiated neonates in this region are scarce. This study aims to address this gap by investigating the time to death and its associated predictors in this vulnerable population.MethodsA retrospective cohort study was conducted at Wolaita Sodo University Comprehensive Specialized Hospital’s Neonatal Intensive Care Unit (NICU) in southern Ethiopia. Medical records of 404 neonates diagnosed with PNA between January 2019 and December 2023 were reviewed. The study followed these neonates for a total of 2889 person-days to assess their survival outcomes. Kaplan-Meier analysis estimated the median time to death, and a Weibull regression model identified independent predictors of mortality.ResultsThe findings revealed the incidence density of PNA-related mortality of 30.8 per 1,000 person-days (95% CI: 25.0-37.9). Notably, nearly 72% of deaths occurred within the first critical week of life, with a median survival time of 20 days. The multivariable Weibull regression analysis identified several factors significantly associated with shorter time to death at p 0.05. These are presence of meconium-stained amniotic fluid (MSAF), low fifth-minute Apgar score (less than 7), birth weight greater than 4000gm, low admission oxygen saturation level, treatment with anticonvulsant, the use of Continuous Positive Airway Pressure (CPAP) for oxygen administration, and need for resuscitation with chest compression.ConclusionThis study highlights the significant burden of PNA-related mortality, particularly during the first week of life, in a resource-limited setting. The findings underscore the urgent need for improved PNA management strategies. Furthermore, specific treatment decisions, including the use of anticonvulsants, oxygen therapy methods, and resuscitation techniques, emerged as crucial factors influencing survival outcomes. These results call for further investigation into these specific interventions and potentially revising PNA management protocols to optimize the chances of survival for asphyxiated neonates in low-resource settings like Ethiopia.