bluuebunny/crossref_metadata_2025_split huggingface dataset:
Estimation of the CSA‐ODF using Bayesian compressed sensing of multi‐shell HARDI
Authors: Duarte‐Carvajalino Julio M. , Lenglet Christophe , Xu Junqian , Yacoub Essa , Ugurbil Kamil , Moeller Steen , Carin Lawrence , Sapiro Guillermo 
Published: December 2013

PurposeDiffusion MRI provides important information about the brain white matter structures and has opened new avenues for neuroscience and translational research. However, acquisition time needed for advanced applications can still be a challenge in clinical settings. There is consequently a need to accelerate diffusion MRI acquisitions.MethodsA multi‐task Bayesian compressive sensing (MT‐BCS) framework is proposed to directly estimate the constant solid angle orientation distribution function (CSA‐ODF) from under‐sampled (i.e., accelerated image acquisition) multi‐shell high angular resolution diffusion imaging (HARDI) datasets, and accurately recover HARDI data at higher resolution inq‐space. The proposed MT‐BCS approach exploits the spatial redundancy of the data by modeling the statistical relationships within groups (clusters) of diffusion signal. This framework also provides uncertainty estimates of the computed CSA‐ODF and diffusion signal, directly computed from the compressive measurements. Experiments validating the proposed framework are performed using realistic multi‐shell synthetic images and in vivo multi‐shell high angular resolution HARDI datasets.ResultsResults indicate a practical reduction in the number of required diffusion volumes (q‐space samples) by at least a factor of four to estimate the CSA‐ODF from multi‐shell data.ConclusionThis work presents, for the first time, a multi‐task Bayesian compressive sensing approach to simultaneously estimate the full posterior of the CSA‐ODF and diffusion‐weighted volumes from multi‐shell HARDI acquisitions. It demonstrates improvement of the quality of acquired datasets by means of CS de‐noising, and accurate estimation of the CSA‐ODF, as well as enables a reduction in the acquisition time by a factor of two to four, especially when “staggered”q‐space sampling schemes are used. The proposed MT‐BCS framework can naturally be combined with parallel MR imaging to further accelerate HARDI acquisitions. Magn Reson Med 72:1471–1485, 2014. © 2013 Wiley Periodicals, Inc.
Noncontrast enhanced four‐dimensional dynamic MRA with golden angle radial acquisition and k‐space weighted image contrast (KWIC) reconstruction
Authors: Song Hee Kwon , Yan Lirong , Smith Robert X. , Xue Yiqun , Rapacchi Stanislas , Srinivasan Subashini , Ennis Daniel B. , Hu Peng , Pouratian Nader , Wang Danny J.J. 
Published: December 2013

PurposeTo explore the feasibility of 2D and 3D golden‐angle radial acquisition strategies in conjunction with k‐space weighted image contrast (KWIC) temporal filtering to achieve noncontrast enhanced dynamic MRA (dMRA) with high spatial resolution, low streaking artifacts and high temporal fidelity.MethodsSimulations and in vivo examinations in eight normal volunteers and an arteriovenous malformation patient were carried out. Both 2D and 3D golden angle radial sequences, preceded by spin tagging, were used for dMRA of the brain. The radial dMRA data were temporally filtered using the KWIC strategy and compared with matched standard Cartesian techniques.ResultsThe 2D and 3D dynamic MRA image series acquired with the proposed radial techniques demonstrated excellent image quality without discernible temporal blurring compared with standard Cartesian based approaches. The image quality of radial dMRA was equivalent to or higher than that of Cartesian dMRA by visual inspection. A reduction factor of up to 10 and 3 in scan time was achieved for 2D and 3D radial dMRA compared with the Cartesian‐based counterparts.ConclusionThe proposed 2D and 3D radial dMRA techniques demonstrated image quality comparable or even superior to those obtained with standard Cartesian methods, but within a fraction of the scan time. Magn Reson Med 72:1541–1551, 2014. © 2013 Wiley Periodicals, Inc.
Bortezomib‐Induced Sweet's Syndrome Confirmed by Rechallenge
Authors: Zobniw Chrystia M. , Saad Samira A. , Kostoff Diana , Barthel Bernd G. 
Published: December 2013

Sweet's syndrome, also known as acute febrile neutrophilic dermatosis, is characterized predominantly by fever, elevated neutrophil count, and erythematous skin lesions composed of plaques and nodules that appear on upper extremities, face, or neck. The incidence of Sweet's syndrome in the general population is unknown due to the rarity of the condition and potential lack of reporting. Bortezomib, an antineoplastic agent that is the standard of care in patients with multiple myeloma, has been reported to be associated with Sweet's syndrome. We describe a 69‐year‐old man who developed Sweet's syndrome during his initial course (after cycle 4) of bortezomib for treatment of multiple myeloma; he again experienced Sweet's syndrome 3.5 years later when rechallenged with bortezomib (after cycle 5) for treatment of relapsed multiple myeloma. The patient's signs, symptoms, and biopsy results were identical during both presentations of Sweet's syndrome. In both instances, the syndrome spontaneously resolved without incident and without supportive treatment with corticosteroids or antihistamines. To our knowledge, this is the first case report of a patient who developed Sweet's syndrome during an initial course of treatment with bortezomib and after rechallenge with bortezomib for relapsed disease. As proteasome inhibitors continue to be a mainstay of therapy for both treatment and salvage therapy for multiple myeloma, this case demonstrates that rechallenge with bortezomib is an option for patients who develop Sweet's syndrome.
Optimizing the Dose of Three‐Factor Prothrombin Complex Concentrate in Traumatic Brain Injury Patients on Warfarin Therapy
Authors: Huynh Thao K. , Costello Jennifer L. , Rebuck Jill A. 
Published: December 2013

Study ObjectiveTo determine the percentage of patients with correction of their first international normalized ratio (INR) less than 1.5 after administration of moderate‐dose three‐factor prothrombin complex concentrate (PCC), 35 IU/kg compared with low‐dose PCC, 25 IU/kg.DesignRetrospective review.SettingCommunity teaching hospital.PatientsA total of 42 adult patients diagnosed with warfarin‐associated traumatic brain injury (TBI) presented with an INR of 1.5 or more and received at least one dose of PCC during a 19‐month study period. The low‐dose group received PCC 25 IU/kg from November 2011–July 2012 and the moderate‐dose group received PCC 35 IU/kg from August 2012–May 2013.Measurements and Main ResultsOf the 42 patients, 25 were in the low‐dose group and 17 were in the moderate‐dose group. Baseline characteristics were similar between both groups in regard to age, sex, weight, creatinine clearance, weekly warfarin dose, initial INR, initial Glasgow Coma Score, and injury severity score. Of the patients in the low‐dose group, 12% achieved INR reversal with first measured INR after PCC administration compared with 69% in the moderate‐dose group (p<0.001). The median time to INR reversal was 6.9 hours in the low‐dose PCC group and 1.9 hours in the moderate‐dose PCC group (p=0.04). There were no differences between the groups in other secondary end points, including stabilization of TBI, days in the intensive care unit, total days of hospitalization, blood product administration, and adverse events.ConclusionsModerately dosed PCC at 35 IU/kg compared with a lower dosage of 25 IU/kg was associated with a higher percentage of INR reversal and more rapid time to INR normalization in patients with TBI. Future randomized controlled studies to further investigate this novel dose and the impact on potential reductions in the use of fresh frozen plasma are warranted.
Cu2ZnSn(S1–xSex)4 thin film solar cells prepared by water‐based solution process
Authors: Jiang Minlin , Lan Fei , Yan Xingzhong , Li Guangyong 
Published: December 2013

AbstractThe kesterite Cu2ZnSn(S1–xSex)4 (CZTSSe) thin film solar cell has been developed rapidly due to its excellence in structural and optical properties and its abundance in raw materials. Both vacuum‐based and solution‐based methods have been successfully employed to fabricate CZTSSe thin film solar cells. In this Letter, we report an environmentally friendly, water‐based, solution process for fabrication of high‐efficiency CZTSSe thin film solar cells. High quality CZTSSe thin film is obtained by selenization under high temperature and Se vapor. An efficiency of 6.2% is achieved on CZTSSe thin film solar cell fabricated by such water‐based solution process. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
New insight into delay‐dependent stability of time‐delay systems
Authors: Xu Shengyuan , Lam James , Zhang Baoyong , Zou Yun 
Published: December 2013

SummaryThis paper presents a new insight into the delay‐dependent stability for time‐delay systems. Because of the key observation that the positive definiteness of a chosen Lyapunov–Krasovskii functional does not necessarily require all the involved symmetric matrices in the Lyapunov–Krasovskii functional to be positive definite, an improved delay‐dependent asymptotic stability condition is presented in terms of a set of LMIs. This fact has been overlooked in the development of previous stability results. The importance of the present method is that a vast number of existing delay‐dependent results on analysis and synthesis of time‐delay systems derived by the Lyapunov–Krasovskii stability theorem can be improved by using this observation without introducing additional variables. The reduction of conservatism of the proposed result is both theoretically and numerically demonstrated. It is believed that the proposed method provides a new direction to improve delay‐dependent results on time‐delay systems. Copyright © 2013 John Wiley & Sons, Ltd.
Cooperative containment of discrete‐time linear multi‐agent systems
Authors: Ma Qian , Lewis Frank L. , Xu Shengyuan 
Published: December 2013

SummaryThis paper investigates the cooperative containment control problem for discrete‐time multi‐agent systems with general linear dynamics. Distributed containment control protocols on the basis of state feedback design and output feedback design are proposed. Necessary and sufficient conditions are presented for both the state feedback and output feedback cases, which are less conservative than those in the literature. These conditions depend on the spectral properties of the topology matrix. Then, effective algorithms are proposed to obtain control gain matrices for both cases based on H ∞  type Riccati design. Simulation examples are provided finally to demonstrate the effectiveness of the proposed design methods. Copyright © 2013 John Wiley & Sons, Ltd.
Frequently Used Coping Scales: A Meta‐Analysis
Authors: Kato Tsukasa 
Published: December 2013

AbstractThis article reports the frequency of the use of coping scales in academic journals published from 1998 to 2010. Two thousand empirical journal articles were selected from the EBSCO database. The COPE, Ways of Coping Questionnaire, Coping Strategies Questionnaire, Coping Inventory for Stressful Situations, Religious‐COPE and Coping Response Inventory were frequently mentioned. In particular, the COPE (20.2%) and Ways of Coping Questionnaire (13.6%) were used the most frequently. In this literature reviewed, coping scales were most often used to assess coping with health issues (e.g. illness, pain and medical diagnoses) over other types of stressors, and patients were the most frequent participants. Further, alpha coefficients were estimated for the COPE subscales, and correlations between the COPE subscales and coping outcomes were calculated, including depressive symptoms, anxiety, negative affect, psychological distress, physical symptoms and well‐being. Copyright © 2013 John Wiley & Sons, Ltd.
Conjugated Linoleic Acid Prevents Ovariectomy‐Induced Bone Loss in Mice by Modulating Both Osteoclastogenesis and Osteoblastogenesis
Authors: Rahman Md Mizanur , Fernandes Gabriel , Williams Paul 
Published: December 2013

AbstractPostmenopausal osteoporosis due to estrogen deficiency is associated with severe morbidity and mortality. Beneficial effects of conjugated linoleic acid (CLA) on bone mineral density (BMD) have been reported in mice, rats and humans, but the effect of long term CLA supplementation against ovariectomy‐induced bone loss in mice and the mechanisms underlying this effect have not been studied yet. Eight‐week old ovariectomized (Ovx) and sham operated C57BL/6 mice were fed either a diet containing 0.5 % safflower oil (SFO) or 0.5 % CLA for 24 weeks to examine BMD, bone turn over markers and osteotropic factors. Bone marrow (BM) cells were cultured to determine the effect on inflammation, osteoclastogenesis, and osteoblastogenesis. SFO/Ovx mice had significantly lower femoral, tibial and lumbar BMD compared to SFO/Sham mice; whereas, no difference was found between CLA/Ovx and CLA/Sham mice. CLA inhibited bone resorption markers whereas enhanced bone formation markers in Ovx mice as compared to SFO‐fed mice. Reverse transcriptase polymerase chain reaction and fluorescence activated cell sorting analyses of splenocytes revealed that CLA inhibited pro‐osteoclastogenic receptor activator of NF‐κB (RANKL) and stimulated decoy receptor of RANKL, osteoprotegerin expression. CLA also inhibited pro‐inflammatory cytokine and enhanced anti‐inflammatory cytokine production of lipopolysaccharide‐stimulated splenocytes and BM cells. Furthermore, CLA inhibited osteoclast differentiation in BM and stimulated osteoblast differentiation in BM stromal cells as confirmed by tartrate resistant acid phosphatase and Alizarin Red staining, respectively. In conclusion, CLA may prevent postmenopausal bone loss not only by inhibiting excessive bone resorption due to estrogen deficiency but also by stimulating new bone formation. CLA might be a potential alternative therapy against osteoporotic bone loss.
Ionenkanalerkrankungen der Niere und Nebenniere
Authors: Beck B.B. , Wollnik B. , Kömhoff M. 
Published: December 2013

Zusammenfassung
Genetische Nierenerkrankungen haben an den sich im Kindes- bis Jugendalter manifestierenden Nierenerkrankungen einen bedeutenden Anteil, gewinnen aber auch zunehmend an Bedeutung für nur langsam progrediente oder spät im Erwachsenenalter auftretende Erkrankungen. Ein erheblicher Teil insbesondere kindlicher Nierenerkrankungen ist mit terminaler Niereninsuffizienz und/oder weiterer relevanter Morbidität verbunden. Eine frühzeitige (molekulare) Diagnosestellung kann für eine bessere prognostische Einschätzung Voraussetzung sein und bietet Möglichkeiten hinsichtlich einer optimierten symptomatischen Therapie.
Mechanistisch betrachtet stellen mit Mutationen in Ionenkanälen assoziierte Nephropathien – neben strukturellen Defekten des glomerulären Filters (z. B. COL4A3, LAMB2, Nephrin) und Störungen der für die Entwicklung des Urogenitaltrakts relevanter Signalwege (z. B. HNF1B, WT1) – eine prototypische und zahlenmäßig wesentliche Gruppe dar.
Die molekulargenetische Aufklärung der (hypokaliämischen) Salzverlusttubulopathien hat ganz wesentlich zu unserem Verständnis der zentralen Rolle der Niere im Salzhaushalt beigetragen. Das Spektrum renaler Ionenkanalerkrankungen soll an den Beispielen der klassischen Salzverlusttubulopathien (Bartter- und Gitelman-Syndrom), der Transient-receptor-potential-(TRP)-Kanalgruppe sowie der Rolle von Kanalveränderungen bei Aldosteronismus und angeborenen Hypertonusformen dargestellt werden.
Efficacy and safety of sorafenib-gemcitabine combination therapy in advanced hepatocellular carcinoma
Authors: Naqi Naeem , Ahmad Shaharyar , Murad Sohail , Khattak Javaid 
Published: December 2013

PURPOSE:
Sorafenib is considered a standard of care in advanced hepatocellular carcinoma (HCC). Its combination with gemcitabine, a pyrimidine analogue with limited friendly hepatic profile may prove beneficial in advanced HCC. The primary objective was to evaluate the efficacy and safety of a sorafenib and gemcitabine combination in patients with advanced HCC.

METHODS:
This was a non-randomized, open-label, single-arm, multi-centric Phase II study conducted in Pakistan where 30 treatment-naive patients aged between 26 and 73 years with Child-Pugh score A or B were treated with sorafenib (400 mg oral) twice daily for 16 weeks along with gemcitabine (1000 mg/m2 intravenous) administered on day 1 and day 8 of a four-week cycle for 16 weeks.

RESULTS:
Of the 18 patients (60%) who completed all four cycles of treatment, eight patients had stable disease, two had partial response, and eight had progressive disease. There was no complete response. The most common (≥ 10% patients) treatment-emergent adverse events were gemcitabine-related thrombocytopenia (40%) followed by sorafenib-related hand-foot skin reaction and anorexia (33% each).

CONCLUSION:
The efficacy of sorafenib gemcitabine combination therapy is similar to the sorafenib alone treatment. However, frequent dose adjustments due to gemcitabine-related toxicities, delays, and corrective treatments make this combination therapy unsafe in the treatment of advanced HCC.
Foreign exchange rate exposure: Evidence from Canada
Authors: Al‐Shboul Mohammad , Anwar Sajid 
Published: December 2013

AbstractUsing weekly data from 2003 to 2011, this paper examines the presence of exchange rate exposure in thirteen Canadian industry sectors. This study contributes to the literature in a number of ways: (i) it considers the presence of exposure not only in the full sample but also in the pre and post‐Global Financial Crisis (GFC) periods, (ii) it considers both linear and nonlinear exposure and (iii) it makes use of the sign and size bias tests to investigate the presence of asymmetric exposure. In general, we find some evidence of linear and nonlinear exposure in the full sample as well as in the pre and post‐GFC sub‐samples. We also find weak evidence of an asymmetric exposure sign effect on stock returns in the full and pre‐GFC sample periods. Stock returns are found to respond asymmetrically to the positive magnitude of exposure in both the‐pre and post‐GFC sample periods. In overall terms, the GFC appears to have weakly contributed to the overall strength of the exposure.
Induction of necrotic cell death by oxidative stress in retinal pigment epithelial cells
Authors: Hanus J , Zhang H , Wang Z , Liu Q , Zhou Q , Wang S 
Published: December 2013

AbstractAge-related macular degeneration (AMD) is a degenerative disease of the retina and the leading cause of blindness in the elderly. Retinal pigment epithelial (RPE) cell death and the resultant photoreceptor apoptosis are characteristic of late-stage dry AMD, especially geographic atrophy (GA). Although oxidative stress and inflammation have been associated with GA, the nature and underlying mechanism for RPE cell death remains controversial, which hinders the development of targeted therapy for dry AMD. The purpose of this study is to systematically dissect the mechanism of RPE cell death induced by oxidative stress. Our results show that characteristic features of apoptosis, including DNA fragmentation, caspase 3 activation, chromatin condensation and apoptotic body formation, were not observed during RPE cell death induced by either hydrogen peroxide or tert-Butyl hydroperoxide. Instead, this kind of cell death can be prevented by RIP kinase inhibitors necrostatins but not caspase inhibitor z-VAD, suggesting necrotic feature of RPE cell death. Moreover, ATP depletion, receptor interacting protein kinase 3 (RIPK3) aggregation, nuclear and plasma membrane leakage and breakdown, which are the cardinal features of necrosis, were observed in RPE cells upon oxidative stress. Silencing of RIPK3, a key protein in necrosis, largely prevented oxidative stress-induced RPE death. The necrotic nature of RPE death is consistent with the release of nuclear protein high mobility group protein B1 into the cytoplasm and cell medium, which induces the expression of inflammatory gene TNFα in healthy RPE and THP-1 cells. Interestingly, features of pyroptosis or autophagy were not observed in oxidative stress-treated RPE cells. Our results unequivocally show that necrosis, but not apoptosis, is a major type of cell death in RPE cells in response to oxidative stress. This suggests that preventing oxidative stress-induced necrotic RPE death may be a viable approach for late-stage dry AMD.
A bacterial pathogen uses dimethylsulfoniopropionate as a cue to target heat-stressed corals
Authors: Garren Melissa , Son Kwangmin , Raina Jean-Baptiste , Rusconi Roberto , Menolascina Filippo , Shapiro Orr H , Tout Jessica , Bourne David G , Seymour Justin R , Stocker Roman 
Published: December 2013

Abstract
Diseases are an emerging threat to ocean ecosystems. Coral reefs, in particular, are experiencing a worldwide decline because of disease and bleaching, which have been exacerbated by rising seawater temperatures. Yet, the ecological mechanisms behind most coral diseases remain unidentified. Here, we demonstrate that a coral pathogen, Vibrio coralliilyticus, uses chemotaxis and chemokinesis to target the mucus of its coral host, Pocillopora damicornis. A primary driver of this response is the host metabolite dimethylsulfoniopropionate (DMSP), a key element in the global sulfur cycle and a potent foraging cue throughout the marine food web. Coral mucus is rich in DMSP, and we found that DMSP alone elicits chemotactic responses of comparable intensity to whole mucus. Furthermore, in heat-stressed coral fragments, DMSP concentrations increased fivefold and the pathogen’s chemotactic response was correspondingly enhanced. Intriguingly, despite being a rich source of carbon and sulfur, DMSP is not metabolized by the pathogen, suggesting that it is used purely as an infochemical for host location. These results reveal a new role for DMSP in coral disease, demonstrate the importance of chemical signaling and swimming behavior in the recruitment of pathogens to corals and highlight the impact of increased seawater temperatures on disease pathways.
A geological perspective on potential future sea-level rise
Authors: Rohling Eelco J. , Haigh Ivan D. , Foster Gavin L. , Roberts Andrew P. , Grant Katharine M. 
Published: December 2013

AbstractDuring ice-age cycles, continental ice volume kept pace with slow, multi-millennial scale, changes in climate forcing. Today, rapid greenhouse gas (GHG) increases have outpaced ice-volume responses, likely committing us to > 9 m of long-term sea-level rise (SLR). We portray a context of naturally precedented SLR from geological evidence, for comparison with historical observations and future projections. This context supports SLR of up to 0.9 (1.8) m by 2100 and 2.7 (5.0) m by 2200, relative to 2000, at 68% (95%) probability. Historical SLR observations and glaciological assessments track the upper 68% limit. Hence, modern change is rapid by past interglacial standards but within the range of ‘normal’ processes. The upper 95% limit offers a useful low probability/high risk value. Exceedance would require conditions without natural interglacial precedents, such as catastrophic ice-sheet collapse, or activation of major East Antarctic mass loss at sustained CO2 levels above 1000 ppmv.