bluuebunny/crossref_metadata_2025_split huggingface dataset:
Evaluation the Role of Interleukin-8 and Interleukin-10 in Myocardial Infarction Patients in Al- Najaf City
Authors: Dhaidan Shnain Al-Abbas Wijdan 
Published: July 2024

This study conducted to evaluate the interleukin-8 and interleukin- 10 level in hypertension and myocardial infarction patients in the period from March to December 2018 by using ELISA technique. A total of thirty three (33) patients from which (5 women and 8 men) with MI and (7 women and 4 men) with hypertension and a total of 19 (7 women and 12 men) healthy individuals were considered as control group. Resulting in, the mean of interleukin-8 level of hypertension and myocardial infarction patients (416.6 pg/ml) and (433.2pg/ml) respectively, with significant elevation comparing with non hypertension (292.03 pg/ml), non myocardial patients (378.9 pg/ml) and control (123.1 pg/ml), furthermore, mean of interleukin-10 level of hypertension and myocardial infarction patients (320.5pg/ml) and (102.9 pg/ml) respectively, with significantly different compared with non patients and control, where show significant increase mean of interleukin-10 level of hypertension compared with non hypertension patients (260.5 pg/ml) and control (129.4 pg/ml), also show a significant decline mean of interleukin-10 level for myocardial in comparison with non myocardial patients (146.3 pg/ml) and control (129.4 pg/ml). Concluded that interleukin-8 (pro and anti- inflammatory) significantly raised in hypertension and myocardial infarction in coronary artery patients, in contrast, this result observed decrease production of anti-inflammatory cytokines IL-10 in myocardial patients.
Mutations and Variants Analysis of Inhibin Gene Subunits in Women with Premature Ovarian Failure
Authors: Juman Khaleel Al-Sabbagh  , Mohammad Sabri A. Razzaq  , Milal M. Abd-Al-Rudha  
Published: July 2024

This study aimed to illustrate the role of inhibin gene as a candidate gene in women with premature ovarian failure (POF) . In this studysixty women who suffered from POF ; and have menopause at least 8 months after the last period , whose ages range between (20-39) years, venous blood samples were collected from these patients who are admitting to the Children and Maternity Hospital and Al-Hilla teaching hospital in Hilla city/Iraq . Also, forty women with no history of menopause with age range approximately matched to that of patients were included as control group . The genotyping was carried out by using PCR , RFLP and SCCP techniques to identify variants in some of candidates genes associated with POF . So regarding to INHα1 gene , the result showed that there is a significant differences between patients and control groups that related to the presence this subunit .The result of RFLP to investigate the variant in this gene showed that most of patients and all control were homozygous for the wild type G allele , and G allele frequency was (92.8%) in patients group and (100%) in control group whereas A allele frequency was (7.2%) POF patients group and (0%) in the control group . The GG genotypes have frequency (85.7%) in POF and (100%) in control group, whereas the AG was found to be (14.3%) and (0%) in patients and control respectively . The results of INHβA1, INHβB1and INHβB2 mutational screening.
Enhancement Efficiency of Active Layer P3HT:POT:DBSA/PCBM Photoactive Solar Cell Device
Authors: Abdullah A. Hussein  
Published: July 2024

In this work we have investigated thin film blend produced from regioregular poly(3-hexylthiophene) (rr-P3HT), Poly(o-toluidine) doped with dodecylbenzene sulphonic (POT:DBSA) and [6,6]-phenyl-C61 butyric acid methylester (PCBM) materials by spin coating method for application as active layer in photoactive solar cell (PSCs). A thin film uniform rr-P3HT:PCBM and rr-P3HT:POT:DBSA:PCBM were successfully deposited on the poly (3,4 ethylenedioxythiophene): poly (styrenesulfonate) (PEDOT:PSS) buffer layer substrate. The absorption spectra of the films were studied by using UV–vis spectrophotometer and Raman spectroscopy. the morphology of films is evaluated by X-ray diffraction (XRD) and atomic force microscopy (AFM) patterns. We have seen that, the efficiency enhancement for the device with a rr-P3HT:POT:DBSA:PCBM film is more significant than for the device with rr-P3HT:PCBM.
Transhumanismo y bioetica en su aplicaciónTranshumanismo y bioetica en su aplicación
Authors: Malla Asmal Alexis Fernando , Bueno León Hernán Patricio 
Published: July 2024

Introducción: El transhumanismo es una ideología que ha tomado fuerza en los últimos años ya que con la innovación en biotecnologías se han abierto puertas para llevar a cabo procesos que ayudan a mejorar al ser humano, plantea mejorar características físicas e intelectuales para alcanzar la perfección. Objetivo: Se pretende exponer problemáticas de índole social, biológico, además de describir como la concepción que se tiene sobre el hombre o humanidad puede verse afectado por la implementación de la tecnología y los diversos procesos de transformación. Metodología: El modelo de investigación se trata de una revisión narrativa que tiene como fin recaudar y analizar el contenido de diversas fuentes bibliográficas como artículos, revistas o bases digitales que estén sujetos a una visión antropológica del transhumanismo y factores que influyan en su aplicación Resultados: Se contrastaron las visiones de diversos autores sobre lo que significa ser humano y las posibles repercusiones a nivel social, además de demostrar que la implementación de tecnologías es un paso natural para la evolución de la humanidad. Conclusión: Las fuentes usadas durante el estudio apoyan el pensamiento de que las tecnologías deben ser implementadas para mejorar la calidad y cantidad de vida, por lo que tener una base moral sólida para su aplicación es fundamental para evitar atentar contra la integridad de aquellos que se sometan a dichos procedimientos.
Modelo de gestión del turismo rural en la comunidad kichwa de Pandanuque
Authors: Manya Grefa Yessenia Silvana , Erazo Alvarez Guido Olivier , Ormaza Andrade Jorge Edwin 
Published: July 2024

Introducción. El modelo de gestión del turismo rural en la comunidad Kichwa de Pandanuque es de vital importancia para mejorar las actividades turísticas y promover el desarrollo económico. El turismo rural, que se ha consolidado en Ecuador en las últimas décadas, es una importante fuente de desarrollo económico y social. La comunidad Kichwa de Pandanuque, situada en un entorno rico cultural y naturalmente, es un potencial destino turístico que podría beneficiarse de un modelo de gestión eficaz para optimizar el bienestar de sus habitantes. Objetivo. La presente investigación tiene como objetivo general diseñar un modelo de gestión integral para el turismo rural en la comunidad kichwa de Pandanuque que promueva el desarrollo sostenible y mejore la calidad de vida de los habitantes. Metodología. La investigación se enfoca en la población económicamente activa de la comunidad kichwa de Pandanuque, es de carácter no experimental y transversal. Se recopilaron datos a través de encuestas a 86 personas, utilizando técnicas cuantitativas y cualitativas. Se analizaron las respuestas para identificar la percepción sobre el modelo de gestión y el turismo rural. Resultados. Los resultados muestran que la mayoría de los encuestados considera que el turismo rural es crucial para el desarrollo económico de Pandanuque. La artesanía se destaca como la principal oportunidad de desarrollo económico, seguida por el turismo sostenible. En cuanto a las atracciones turísticas, el turismo gastronómico es el más relevante. La comunidad apoya fuertemente la implementación de un modelo de gestión eficaz para maximizar los beneficios del turismo rural y asegurar su sostenibilidad. Conclusión. La comunidad Kichwa de Pandanuque posee un gran potencial turístico que, con un modelo de gestión adecuado, puede ser desarrollado para impulsar el desarrollo económico y potenciar las condiciones vitales de sus habitantes. El turismo gastronómico y comunitario se presentan como las principales atracciones, y la artesanía se destaca como una oportunidad viable de progreso económico. Área de estudio general: Administración de Empresas. Área de estudio específica: Gestión de proyectos.
Early Jurassic A-type granite and monzodiorite from the Baoji batholith: Implication for tectonic transition from post-collision to post-orogenic extension in the Qinling Orogenic Belt, China
Authors: Gong Xiangkuan , Abuduxun Nijiati , Jia Xiaoliang , Cheng Yuanfeng , Cai Hongming , Wu Xueqian , Yang Haodong 
Published: July 2024

Introduction: The early Jurassic granitoids in the Qinling Orogenic Belt (QOB) play a crucial role in understanding the tectonic implications for the geological evolution of China. To elucidate the early Jurassic tectonic setting of QOB, we performed a comprehensive analysis of zircon U-Pb ages, whole-rock geochemistry, and in situ zircon Lu-Hf isotopes from early Jurassic monzodiorite and Kfeldspar granite within the Baoji batholith in western QOB.Geochronology Method and Results: The intrusions yielded zircon U-Pb ages of 186 ± 2 Ma and 188 ± 2 Ma, respectively.Geochemistry Results: The monzodiorites are characterized by relatively high MgO, Rb, Th, U, and LREE contents, as well as low P, Ti, and HREE contents. They also exhibit high Nb/Ta ratios (20.6–23.4). The zircon εHf(t) values for the monzodiorite sample range from −4.36 to 6.47, indicating significant contributions from a fertile continental lithospheric mantle with the involvement of crustal components. The K-feldspar granites are enriched in K2O+ Na2O, Rb, Zr, Hf, and Nb, and lower Ba, Sr, Ti, and P. They exhibit high Nb/Ta and Ga/Al ratios but low Y/Nb and Yb/Ta ratios. Their geochemical characteristics reveal an A-type granite affinity with elevated zircon saturation temperatures (848°C–900 °C). Additionally, the K-feldspar granite exhibits REE and trace element patterns similar to those observed in the monzodiorite. However, a wide range of zircon εHf(t) values (−4.72 to 3.98), differing from those of the monzodiorite, indicate that the parental magma of the K-feldspar granite experienced magma mixing between a monzodioritic magma and a crustal-derived felsic magma.Discussion: These findings suggest that both A-type K-feldspar granite and monzodiorite likely formed during post-orogenic processes. Additionally, the QOB commenced its postorogenic evolution as an extensional tectonic environment during the early Jurassic period.
Case report: A rare cause of intestinal perforation in a third-trimester pregnant woman
Authors: Stiegler Clemens , Kapitza Christopher , Weber Florian , Patalakh Wladimir , Schäfer Claus 
Published: July 2024

BackgroundAn acute abdomen is a medical emergency that requires early diagnosis and treatment. In pregnancy, this process is significantly more challenging, and radiological findings are sometimes unclear due to the enlarged uterus displacing other structures. Moreover, endometriosis-related complications are rare, and the disease is often undiagnosed.Case presentationWe report a case of acute perforation of the cecum and appendix during pregnancy (35 weeks of gestation) caused by a previously unknown, deep infiltrating endometriosis with focal ulceration of the affected bowel wall, which sonographically seemed to be acute appendicitis.ConclusionDespite the relatively low risk, clinicians should be aware of possible endometriosis-associated complications in pregnancy with potentially life-threatening events, even in previously unknown endometriosis. Further studies should evaluate intestinal complications during pregnancy in relation to previous treatment of intestinal endometriosis (conservative vs. surgical).
Serum from patients with cirrhosis undergoing liver transplantation induces permeability in human pulmonary microvascular endothelial cells ex vivo
Authors: Bokoch Michael P. , Xu Fengyun , Govindaraju Krishna , Lloyd Elliot , Tsutsui Kyle , Kothari Rishi P. , Adelmann Dieter , Joffre Jérémie , Hellman Judith 
Published: July 2024

IntroductionPatients with cirrhosis undergoing liver transplantation frequently exhibit systemic inflammation, coagulation derangements, and edema, indicating endothelial dysfunction. This syndrome may worsen after ischemia–reperfusion injury of the liver graft, coincident with organ dysfunction that worsens patient outcomes. Little is known about changes in endothelial permeability during liver transplantation. We hypothesized that sera from these patients would increase permeability in cultured human endothelial cells ex vivo.MethodsAdults with cirrhosis presenting for liver transplantation provided consent for blood collection during surgery. Sera were prepared at five time points spanning the entire operation. The barrier function of human pulmonary microvascular endothelial cells in culture was assessed by transendothelial resistance measured using the ECIS ZΘ system. Confluent cells from two different endothelial cell donors were stimulated with human serum from liver transplant patients. Pooled serum from healthy men and purified inflammatory agonists served as controls. The permeability response to serum was quantified as the area under the normalized resistance curve. Responses were compared between time points and analyzed for associations with clinical characteristics of liver transplant patients and their grafts.ResultsLiver transplant sera from all time points during surgery-induced permeability in both endothelial cell lines. The magnitude of permeability change was heterogeneous between patients, and there were differences in the effects of sera on the two endothelial cell lines. In one of the cell lines, the severity of liver disease was associated with greater permeability at the start of surgery. In the same cell line, serum collected 15 min after liver reperfusion induced significantly more permeability as compared to that collected at the start of surgery. Early postreperfusion sera from patients undergoing living donor transplants induced more permeability than sera from deceased donor transplants. Sera from two exemplary cases of patients on preoperative dialysis, and one patient with an unexpectedly long warm ischemia time of the liver graft, induced exaggerated and prolonged endothelial permeability.DiscussionSerum from patients with cirrhosis undergoing liver transplantation induces permeability of cultured human pulmonary microvascular endothelial cells. Increased endothelial permeability during liver transplantation may contribute to organ injury and present a target for future therapeutics.
Circulating free DNA as a diagnostic marker for echinococcosis: a systematic review and meta-analysis
Authors: Luo Xiaoqin , Jiang Ping , Ma Jideng , Li Zian , Zhou Jianwu , Wei Xiaoxing , A Jide , Chai Jinping , Lv Yanke , Cheng Peng , Cao Chunhua , A Xiangren 
Published: July 2024

IntroductionEchinococcosis is a chronic zoonotic disease caused by tapeworms of the genus Echinococcus. The World Health Organization (WHO) has identified encapsulated disease as one of 17 neglected diseases to be controlled or eliminated by 2050. There is no accurate, early, non-invasive molecular diagnostic method to detect echinococcosis. The feasibility of circulating free DNA as a diagnostic method for echinococcosis has yielded inconclusive results in a number of published studies. However, there has been no systematic evaluation to date assessing the overall performance of these assays. We report here the first meta-analysis assessing the diagnostic accuracy of cfDNA in plasma, serum, and urine for echinococcosis.MethodsWe systematically searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), and WeiPu databases up to 17 January 2024, for relevant studies. All analyses were performed using RevMan 5.3, Meta-DiSc 1.4, Stata 17.0, and R 4.3.1 software. The sensitivity, specificity, and other accuracy indicators of circulating free DNA for the diagnosis of echinococcosis were summarized. Subgroup analyses and meta-regression were performed to identify sources of heterogeneity.ResultsA total of 7 studies included 218 patients with echinococcosis and 214 controls (156 healthy controls, 32 other disease controls (non-hydatid patients), and 26 non-study-targeted echinococcosis controls were included). Summary estimates of the diagnostic accuracy of cfDNA in the diagnosis of echinococcosis were as follows: sensitivity (SEN) of 0.51 (95% CI: 0.45–0.56); specificity (SPE) of 0.99 (95% CI: 0.97–0.99); positive likelihood ratio (PLR) of 11.82 (95% CI: 6.74–20.74); negative likelihood ratio (NLR) of 0.57 (95% CI: 0.41–0.80); diagnostic ratio (DOR) of 36.63 (95% CI: 13.75–97.59); and area under the curve (AUC) value of 0.98 (95% CI: 0.96–1.00).ConclusionExisting evidence indicates that the combined specificity of circulating cfDNA for echinococcosis is high. However, the combined sensitivity performance is unsatisfactory due to significant inter-study heterogeneity. To strengthen the validity and accuracy of our findings, further large-scale prospective studies are required.Systematic review registrationThe systematic review was registered in the International Prospective Register of Systematic Reviews PROSPERO [CRD42023454158]. https://www.crd.york.ac.uk/PROSPERO/.
Age-related reduction in anxiety and neural encoding of negative emotional memory
Authors: Chaudhary Shefali , Zhang Sheng , Chen Yu , Dominguez Jacqueline C. , Chao Herta H. , Li Chiang-Shan R. 
Published: July 2024

IntroductionOlder adults experience less anxiety. We examined how memory of negative emotional images varied with age and may reflect age-related differences in anxiety.MethodsFifty-one adults, age 22-80 years, underwent imaging with a memory task where negative and neutral images were displayed pseudo-randomly. They were queried post-scan about the images inter-mixed with an equal number of images never displayed. Sensitivity (d’) and reporting bias (Z-score of false alarm rate; Z[FAR]) were quantified with signal detection theory.ResultsAge was negatively correlated with both Spielberg State Trait Anxiety Inventory (STAI) state score and d’ (negative – neutral) and positively with Z[FAR] (negative – neutral). However, STAI score and d’ or Z[FAR] (negative – neutral) were not significantly correlated. In whole-brain regression, STAI score was correlated with higher activity of the right middle/superior temporal gyri/temporal parietal junction (MTG/STG/TPJ) for “negative correct – incorrect” – “neutral correct – incorrect” trials. Further, the MTG/STG/TPJ activity (β) was also negatively correlated with age. Mediation analyses supported a complete mediation model of age → less anxiety → less MTG/STG/TPJ β.DiscussionTogether, the findings demonstrated age-related changes in negative emotional memory and how age-related reduction in anxiety is reflected in diminished temporoparietal cortical activities during encoding of negative emotional memory.
Exploring the association of physical activity on cognitive function in older adults from observational and genetic insights: a combined NHANES and Mendelian randomization study
Authors: Liu Hai-yan , Zhang Yi-Jing , Zhang Wen-you 
Published: July 2024

BackgroundCognitive function (CF) deterioration is a pressing concern in geriatric research. This study aimed to explore the relationship between physical activity (PA) and CF in older adults.MethodsThis study adopted a dual approach, employing both observational and genetic approaches through data from the National Health and Nutrition Examination Survey (NHANES) 2011–2014 and Mendelian Randomization (MR) analysis. For the NHANES component, PA levels were evaluated using the Global Physical Activity Questionnaire, and CF was assessed via standardized tests. Multivariate regression, threshold effect analysis, smoothing curve fitting, and subgroup analyses were conducted to examine the association between PA and CF. In parallel, MR methods, using genetic variants as instrumental variables, assessed the causal impact of PA on CF and related conditions such as Alzheimer’s disease and dementia.ResultsObservational findings from NHANES demonstrated a positive correlation between PA and CF, notably among female participants. The detailed analysis identified specific thresholds of PA that correlate with cognitive enhancements. However, MR results did not support a significant causal relationship between PA and CF or dementia-related outcomes, indicating an absence of a direct genetic basis for the observational associations.ConclusionAlthough observational data from NHANES suggest that PA is positively associated with CF in older adults, particularly among women, MR analysis did not confirm these findings as causally related. The discrepancy highlights the complexity of the PA-CF relationship and underscores the need for further research. These results emphasize the potential of PA as a modifiable risk factor for CF, though causal effects remain to be definitively established.
The relationship between the dietary index based Meiji nutritional profiling system for adults and lifestyle-related diseases: a predictive validity study from the National Institute for Longevity Sciences—Longitudinal Study of Aging
Authors: Yu Tao , Zhang Shu , Wakayama Ryota , Horimoto Tomohito , Tange Chikako , Nishita Yukiko , Otsuka Rei 
Published: July 2024

BackgroundNutritional profiling system (NPS) holds promise as a public health tool for companies to measure product healthiness and for individuals in making healthier food choices. The Meiji NPS for adults specifically targets lifestyle-related diseases prevalent among Japan’s adult population, including overweight/obesity, hypertension, diabetes, and dyslipidemia. This study examined the cross-sectional association between the Meiji NPS for adults Dietary Index (MNfA-DI) and indicators of lifestyle-related diseases in a population.MethodsThe study comprised 1,272 middle-aged individuals (40–64 years, 50.1% male) who participated in the seventh wave (2010–2012) of the National Institute for Longevity Sciences—Longitudinal Study of Aging project, with no missing data on three-day dietary records. The MNfA-DI was computed at the individual diet level (accounting for the whole diet) using arithmetic energy-weighted means. A higher MNfA-DI indicated a greater nutritional quality of an individual’s overall diet. Lifestyle-related disease indicators included body mass index (BMI, kg/m2), body fat (%), systolic and diastolic blood pressure (mmHg), fasting plasma glucose (mg/dL), HbA1c (%), triglyceride levels (mg/dL), LDL, and HDL cholesterol levels (mg/dL). A multiple regression model was used to assess the association between the MNfA-DI and lifestyle-related disease indicators, adjusting for demographics, socioeconomic status, lifestyle factors, disease history, and energy intake as covariates, depending on the outcome.ResultsThe median (interquartile range) age and MNfA-DI were 53.0 (46.0, 59.0) years and 10.1 (6.0, 14.0) points, respectively. MNfA-DI was negatively associated with body fat [partial regression coefficient (95% confidence interval) −0.04 (−0.07, −0.01)], diastolic blood pressure [−0.08 (−0.17, −0.002)], fasting plasma glucose [−0.18 (−0.33, −0.01)], and triglyceride [−1.36 (−2.16, −0.55)]. Additionally, MNfA-DI was also associated with almost indicators (except for LDL and HDL cholesterol) among participants with a BMI between 18.5 and 24.9 kg/m2.ConclusionThese findings suggest that the Meiji NPS for adults could be associated with a lower risk of lifestyle-related diseases. In addition, from a public health nutrition perspective, the Meiji NPS for adults may be useful to assess the food healthiness of the adult population.