bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resistance to neonicotinoids is associated with metabolic detoxification mechanisms in Anopheles coluzzii from agricultural and urban sites in southern Benin
Authors: Tchigossou Genevieve , Dossou Camille , Tepa-Yotto Ghislain , Koto Massioudou , Atoyebi Seun Michael , Tossou Eric , Adanzounon Danahé , Gouété Marie , Sina Haziz , Tchouakui Magellan , Dione Michel , Wondji Charles , Djouaka Rousseau 
Published: August 2024

BackgroundNeonicotinoids are gradually being introduced into malaria vector control due to their mode of action that targets insect nicotinic acetylcholine receptors (nAChRs). However, prior to scaling up novel insecticides, it is important to assess the susceptibility of the mosquito population to this molecule. The present study aimed to determine the susceptibility level of mosquitos collected from agricultural and urban sites against neonicotinoids in Benin.Material and methodsAn. gambiae sl. larvae were collected from three urban sites and two agricultural sites in southern Benin. An. gambiae sl. larvae collected from three urban and two agricultural sites in southern Benin were exposed to neonicotinoids (clothianidin, acetamiprid, and imidacloprid) for 1 hour, and mortality rates were monitored from 24h to day 7 post-exposure. After molecular identification of the samples, Taqman assays were used to genotype key pyrethroid-resistant markers, and qPCRs were performed to establish the level of expression of detoxification enzymes in resistant mosquitoes.ResultsOverall, resistance to acetamiprid and imidacloprid was observed in the five study sites surveyed whereas full susceptibility was recorded to clothianidin. Anopheles coluzzii was the only species found in all sites. TaqMan genotyping showed a very low presence of key pyrethroid-resistant markers suggesting that metabolic resistance is more implicated in neonicotinoid resistance in Anopheles. coluzzii populations from southern Benin. qPCR performed revealed overexpression of P450 genes (CYP6M2, CYP6P4, CYP6Z1, CYP6Z2, and CYP4G16) and sensory proteins (Sap1, Sap2, and Sap3).ConclusionThis first assessment of neonicotinoid resistance in Benin showed evidence of neonicotinoid resistance in both agricultural and urban areas. However, full susceptibility to clothianidin was observed, showing that this insecticide could be used to enhance the efficacy of control tools. In addition, there is a need of an integrated approach, including coordinated education on pesticide use, to improve the overall management of insecticide resistance in both agricultural and public health sectors.
Diagnosis and treatment of Robert’s uterus combined with transverse uterine septum: a case report and review of the literature
Authors: Chen Mingqian , Yang Xiaoyu , Zhang Bin , Fu Jialiang , Lan Yi , Chi Yugang 
Published: August 2024

BackgroundRobert’s uterus combined with transverse uterine septum is a rare uterine malformation. Only one case has been reported to date, and it is challenging to diagnose and treat.Case presentationHere we report the case of a 19-year-old female had undergone multiple treatments at a previous hospital for primary amenorrhea and periodic lower abdominal pain, with the cause remaining unclear. Ultrasonography and magnetic resonance imaging conducted at our hospital displayed the presence of uterine dysplasia with an incomplete septum. Following a multidisciplinary discussion, a preliminary diagnosis of Robert’s uterus combined with transverse uterine septum was made. Following this, laparoscopic exploration and ultrasound-guided hysteroscopic metroplasty were performed. The patient experienced periodic menstruation postoperatively and did not manifest periodic lower abdominal pain.ConclusionRobert’s uterus combined with transverse uterine septum is a very rare uterine malformation, with hysteroscopic metroplasty being the preferred surgical option. Nevertheless, preoperative diagnosis is extremely difficult, and there are also many difficulties in the surgical process. This case outlines the diagnostic and treatment process of a patient with Robert’s uterus and transverse uterine septum. It is of great significance to fill the gap in clinical diagnosis and treatment of this special uterine malformation.
Effect of kaempferol ingestion on physical activity and sleep quality: a double-blind, placebo-controlled, randomized, crossover trial
Authors: Ikeda Yasutaka , Gotoh-Katoh Aina , Okada Shinpei , Handa Shuichi , Sato Teruyuki , Mizokami Tsubasa , Saito Bungo 
Published: August 2024

BackgroundKaempferol (KMP), a flavonoid in edible plants, exhibits diverse pharmacological effects. Growing body of evidence associates extended lifespan with physical activity (PA) and sleep, but KMP’s impact on these behaviors is unclear. This double-blind, placebo-controlled, crossover trial assessed KMP’s effects on PA and sleep.MethodsA total of 33 city workers (17 males and 16 females) participated in this study. They were randomly assigned to take either 10 mg of KMP or placebo for 2 weeks in the order allocated, with a 7-day washout period in between. All participants wore an accelerometer-based wearable device (Fitbit Charge 4), which monitored daily PA, heart rate (HR), and HR variability during sleep.ResultsThe duration of wearing the device was 23.73 ± 0.04 h/day. HR decreased in each PA level, and the mean daily step count and distance covered increased significantly during KMP intake compared to placebo. The outing rate, number of trips, number of recreational activities, and time spent in recreation on weekends increased. Sleep quality improved following KMP intake. The decrease in HR and increase in RMSSD may be important in mediating the effects of these KMPs.ConclusionKMP leads to behavioral changes that subsequently improve sleep quality and potentially improve long-term quality of life.Clinical Trial Registrationhttps://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000048447, UMIN000042438.
Recurrent bladder urothelial carcinoma complicated with primary bladder large cell neuroendocrine carcinoma: a case report and literature review
Authors: Cui Jiarui , Zhao Qing , Yu Chunhong , Ma Pengfei , Li Shoubin 
Published: August 2024

ObjectiveTo improve the understanding, diagnosis and treatment of bladder large cell neuroendocrine carcinoma (LCNEC).MethodsA clinical case of bladder LCNEC admitted to our hospital was reported. The epidemiology, prognosis, diagnosis and treatment methods of large cell neuroendocrine carcinoma were reviewed. The diagnosis and treatment status and prognosis were discussed based on the literature.ResultsThe female patient was admitted to hospital for “more than 4 years after TURBT and intermittent hematuria for more than 2 years”. She was diagnosed as recurrent bladder cancer and underwent “radical cystotomy + hysterectomy”. The postoperative pathological findings were high-grade urothelial carcinoma of the bladder neck and large cell neuroendocrine carcinoma of the bladder. The patient recovered well after surgery, but refused radiotherapy and chemotherapy and is still under close follow-up.ConclusionBladder LCNEC is clinically rare, has unique pathological features, is more aggressive than traditional urothelial carcinoma, and has a poor prognosis. Surgery, chemotherapy and radiotherapy should be combined with multi-mode treatment.
The effects of foot orthoses on radiological parameters and pain in children with flexible flat feet: a systematic review and meta-analysis
Authors: Liu Chao , Zhang HongHao , Li JianPing , Li ShiJia , Li GuQiang , Jiang XiangZhan 
Published: August 2024

ObjectiveThis study aimed to investigate the impact of foot orthoses on foot radiological parameters and pain in children diagnosed with flexible flatfoot.MethodsA comprehensive search was conducted across several databases, including PubMed, Web of Science, EMBASE, Cochrane Library, and EBSCO, covering publications from the inception of each database up to 8 June 2024. The study focused on randomized controlled trials investigating the use of foot orthoses for treating flexible flat feet in children. Four researchers independently reviewed the identified literature, extracted relevant data, assessed the quality of the studies, and performed statistical analyses using RevMan 5.4 software.ResultsSix studies involving 297 participants were included. The methodological quality of the included literature ranged from moderate to high. Radiological parameters of the foot improved significantly in older children with flexible flat feet following foot orthotic intervention compared to controls, particularly in the lateral talar-first metatarsal angle [mean difference (MD) = −2.76, 95% confidence interval (95% CI) −4.30 to −1.21, p = 0.0005], lateral talo-heel angle (MD = −5.14, 95% CI −7.76 to −2.52, p = 0.0001) and calcaneal pitch angle (MD = 1.79, 95% CI 0.88–2.69, p = 0.0001). These differences were statistically significant. Additionally, foot orthoses significantly improved the ankle internal rotation angle and reduced foot pain in children with symptomatic flexible flatfoot (MD = −2.51, 95% CI −4.94 to −0.07, p = 0.04).ConclusionThe use of foot orthoses positively impacts the improvement of radiological parameters of the foot and reduces pain in older children with flexible flat feet. However, in younger children with flexible flat feet, the improvement from foot orthoses was not significant, likely due to challenges in radiological measurements caused by the underdevelopment of the ossification centers in the foot. Further studies are needed. Consequently, the results of this meta-analysis support the implementation of an early intervention strategy using foot orthoses for the management of symptomatic flat feet in older children.Systematic Review Registrationhttps://www.crd.york.ac.uk/, PROSPERO [CRD42023441229].
“Left on read” examining social media users’ lurking behavior: an integration of anxiety and social media fatigue
Authors: Liu Xiaoyu , Feng Ran , Chen Xiaobing , Yuan Yu 
Published: August 2024

IntroductionWith the widespread use of social media, the behavior and mindset of users have been transformed, leading to a gradual increase in lurking users, which can impede the sustainable development of social media platforms. In this study, we aim to investigate the impact of intrinsic and extrinsic motivational factors on social media users’ anxiety, social media fatigue, and lurking behavior.MethodologyFor the confirmation of these phenomena and to validate the theories, a structural equation model was constructed based on the SSO (Stressor-Strain-Outcome) theoretical framework. The model was then tested and validated with data from 836 valid online surveys. These data were analyzed using SPSS 27.0 and AMOS 24.0 software.ResultsThe results indicate that intrinsic motivations (such as social comparison and privacy concerns) and extrinsic motivations (including information overload, functional overload, and social overload) are positively associated with users’ lurking behavior through the mediating effects of social media fatigue and anxiety. Additionally, for the mediator variables, social media fatigue was found to be positively associated with anxiety.DiscussionThese findings underscore the importance of social media platforms considering both intrinsic and extrinsic motivational factors to mitigate user anxiety and social media fatigue. By addressing these factors, platforms can foster user satisfaction and increase engagement, ultimately contributing to the sustainable development of social media platforms.
The impact of social media information exposure on appearance anxiety in young acne patients: a moderated chain mediation model
Authors: Zhang Zhijian , Zhou Min 
Published: August 2024

IntroductionThe boom of social media has provided a wider space for ordinary people to display themselves, but visual presentation has also intensified the focus on appearance, which in turn triggers anxiety about appearance. The study aims to investigate the impact of social media information exposure on appearance anxiety in young acne patients and the pathways and mechanisms that cause this effect.MethodsA moderated chain mediation model was constructed, and a questionnaire was used to collect information on social media information exposure, internalization of beauty ideals, fear of negative evaluation, self-esteem, and appearance anxiety in young acne patients (N = 382), and the relationships between the variables were explored through regression analysis.ResultsThe results show that there was a significant path of effect (t &gt; 2.5, p &lt; 0.05) between social media information exposure, internalization of beauty ideals, fear of negative evaluation, and appearance anxiety. Self-esteem significantly moderated the relationship between social media information exposure and internalization of beauty ideals (t &lt; −2, p &lt; 0.05).DiscussionIn conclusion, in young acne patients, internalization of beauty ideals and fear of negative evaluation chain mediated the association between social media information exposure and appearance anxiety, and young acne patients’ internalization of beauty ideals was inversely correlated with their level of self-esteem.
Bibliometric analysis of research on digestive system tumors and depression
Authors: Qu Ying , Nie Duorui , Song Yuwei , Cai Xiaojun , Gong Yilin , Chen Sheng , Ye Jia , Li Jing 
Published: August 2024

BackgroundMalignant tumors of the digestive system pose a serious threat to human health due to their highly malignant nature. Depression, as the most common psychiatric symptom of digestive system tumors, has attracted much attention regarding its potential relationship with these tumors. A thorough investigation into the connection between digestive system tumors and depression is extremely important for strengthening patients’ quality of life and treatment outcomes.MethodsFrom 2014 to 2023, we conducted a literature search using specific keywords in the Web of Science Core Collection (WoSCC) and performed visual analysis of the selected literature using Microsoft Excel, CiteSpace, and VOSviewer software. In this study, we analyzed countries, institutions, authors, journals, and keywords.ResultsA total of 384 research articles on the relationship between digestive system tumors and depression were identified. The number of publications showed a gradual increase over time. In terms of disciplinary distribution, Oncology, Health Care Sciences Services, and Medicine General Internal ranked top in terms of publication volume. In terms of geographical distribution, China and the United States were the countries contributing the most publications. Additionally, Maastricht University contributed the most publications. Regarding authors, Beekman, Aartjan T.F. and Dekker, Joost had the highest number of publications, while Zigmond, A.S. had the most citations. It is worth mentioning that Supportive Care in Cancer was the journal with the most publications in this field. In terms of keyword analysis, research mainly focused on mechanisms and treatment strategies related to the relationship between digestive system tumors and depression.ConclusionThe relationship between digestive system tumors and depression has become a new research hotspot in recent years, offering new directions for future research. This research reveals novel perspectives on comprehending the connection between the two, which can guide future research and practice.
Suicidal ideation in Chinese adolescents: prevalence, risk factors, and partial mediation by family support, a cross-sectional study
Authors: Bao Xiyan , Guo Tianming , Xu Li , Chen Wanming , Luan Lingshu , Yang Haidong , Zhang Xiaobin 
Published: August 2024

BackgroundSuicidal ideation is a pressing public health concern, particularly among adolescents. The objective of this study was to examine the prevalence of and factors associated with suicidal ideation in Chinese adolescents, addressing an important gap in current research.MethodsThis study employed an online survey of 3443 adolescents in Lianyungang, using a cross-sectional design. The assessment included the use of the Patient Health Questionnaire-9, the seven-item Generalized Anxiety Disorder instrument, and the Perceived Social Support Scale to evaluate suicidal ideation, anxiety symptoms, and social support in adolescents, respectively.ResultsIn adolescents, the prevalence of suicidal ideation was 22.1%, with a significantly higher proportion among female adolescents than among males (27.9% vs 16.9%, P &lt; 0.001). Binary regression analysis identified (OR = 1.788, 95% CI: 1.467–2.177, P &lt; 0.001), anxiety symptoms (OR = 10.035, 95% CI: 7.441–13.534, P &lt; 0.001), total PHQ-9 scores of mothers (OR = 1.040, 95%CI: 1.003 – 1.078, P = 0.034), total GAD-7 scores of mothers (OR = 0.958, 95%CI: 0.919 – 0.998, P = 0.039), and moderate parental relationships (OR = 2.042, 95% CI: 1.630–2.557, P &lt; 0.001) to be risk factors for suicidal ideation; family support was a protective factor (OR = 0.888, 95% CI: 0.859–0.918, P &lt; 0.001). Furthermore, family support partially mediates the relationship between anxiety symptoms and suicidal ideation among adolescents (9.28%).ConclusionsThis study highlights high adolescent suicidal ideation rates and recommends gender-specific interventions, anxiety management, and family support for improvement in mental health status.
Readiness of nurses when faced with a patient’s death
Authors: Kowalenko Marta , Krajewska-Kułak Elżbieta , Kowalewska Beata , Kułak-Bejda Agnieszka , Kulik Teresa , Gaworska-Krzemińska Aleksandra , Van Damme-Ostapowicz Katarzyna 
Published: August 2024

IntroductionThe death of a patient negatively affects the professional dimension of nurses’ functioning and also their private lives, where professional experiences and emotions are often transmitted.Aim of the studyThe main aim of the study was to discover how the nursing staff assessed their self-efficacy in dealing with the death of a patient.Materials and methodsThe researchers used a diagnostic survey method and a self-authored survey, Life Satisfaction Scale (SWLS), Coping Inventory for Stressful Situations (CISS), Generalized Self-Efficacy Scale (GSES), Courtauld Emotional Control Scale (CECS), The Death Anxiety and Fascination Scale with the Death Anxiety Subscale. The study group consisted of 287 individuals.ResultsWorking in a hospital is stressful in the opinion of 79.44% of the respondents. 39.37% of the respondents feared death. In the course of work, the death of a patient in the department was sometimes experienced by 34.84% of the respondents, always experienced by 29.97%. The respondents usually did not make their compassion for a dying patient based on the patient’s position in society (57.84%). In the case of the majority (84.67%) of the respondents, the employer did not provide mental support for the staff in difficult situations. The majority of the respondents did not feel the need to broaden their knowledge of death and dying (64.11%).ConclusionThe surveyed nurses most often presented low or average life satisfaction, high self-efficacy, average levels of stress and coping in all three styles (with a preference for avoidance-oriented), and a high level of death fascination and an average level of death anxiety. The majority of the nurses in difficult situations and when a stressful situation occurred did not receive support from their employer or from physicians, but could count on the assistance of fellow nurses and a divisional nurse. The majority of the respondents felt that psychological support in their work was important and would gladly benefit from it. Although most nurses did not feel the need to broaden their knowledge of death/dying, they would take part in such a course if it were possible.
An unexpected complication after removing bladder foreign body: a case report
Authors: Gong Pengfeng , Shen Jie 
Published: August 2024

BackgroundBladder foreign bodies commonly arise as urgent issues in urology. These foreign bodies are typically extracted through cystoscopy or cystotomy. In general, these surgical approaches rarely lead to serious complications.MethodsA 34-year-old woman presented with a one-year history of frequent urination, urgency, and urodynia. Abdominal computed tomography (CT) scan revealed the presence of an intrauterine device (IUD) [a medium-sized (20 mm × 22 mm) circular IUD] near the posterior bladder wall. The object was successfully removed via cystoscopy. Two months later, the patient exhibited food residues in her urine. Enterography demonstrated a large amount of contrast agent had entered the bladder from the small intestine. We repaired the bladder with catheter for 2 weeks, removed the segment of small intestine with fistula, and anastomosed the intestine canal.ResultsPost-operation urine tests yielded negative results, and the patient resumed a normal diet.ConclusionsEvaluating the location between foreign body and bladder wall, which is based on medical history, CT scan, and cystoscopy examination, is essential for doctors before they remove the foreign body by cystoscopy or laparoscopy. It is necessary to check for leakage by applying radiopaque fluids under fluoroscopy after removing the foreign body, which migrates from other abdominal organs. If there is damage in the bladder or other organs, laparoscopic surgery or open surgery should be performed immediately.
Coseismic Slip and Downdip Afterslip Associated with the 2021 Maduo Earthquake Revealed by Sentinel-1 A/B Data
Authors: He Yang , Tian Zhen , Su Lina , Feng Hongwu , Yan Wenhua , Zhang Yongqi 
Published: August 2024

On 22 May 2021, an earthquake (98.3° E and 34.59° N) struck Maduo town in Qinghai province, occurring along a relatively obscure secondary fault within the block. We utilized 105 archived Sentinel-1A/B acquisitions to investigate the coseismic deformation and the evolution of postseismic displacements in both the temporal and spatial domains, as well as the associated dynamic mechanisms of the 2021 Maduo earthquake. The interference fringes and coseismic deformation revealed that the primary feature of this event was the rupture along a left-lateral strike-slip fault. The released seismic moment was close to 1.88 × 1020 N·m, which is equivalent to an Mw 7.45 event. Simultaneously, the maximum coseismic slip reached approximately 4 m along the fault plane. The evolution of postseismic displacements in both the temporal and spatial domains over 450 days following the mainshock was further analyzed to explore the underlying physical mechanisms. Generally, the patterns of coseismic slip and afterslip were similar, although the postseismic displacements decayed rapidly over time. The modeled afterslip downdip of the coseismic rupture (at depths of 15–40 km) effectively explains the postseismic deformation, with a released moment estimated at 4.57 × 1019 N·m (corresponding to Mw 7.04). Additionally, we found that regions with high coseismic slip tend to exhibit weak seismicity, and that afterslip and aftershocks are likely driven by each other. Finally, we estimated the Coulomb Failure Stress changes (ΔCFS) triggered by both coseismic rupture and aseismic slip resulting from this event. The co- and postseismic ΔCFS show similar patterns, but the magnitude of the postseismic ΔCFS is much lower (≤0.01 MPa). We found that ΔCFS notably increased on the Yushu segment of the Garze-Yushu-Xianshuihe Fault (GYXF), as well as the Maqin–Maqu and Tuosuo Lake sections of the East Kunlun Fault (EKF). Therefore, we infer that these fault segments may have a higher potential seismic risk and should be carefully monitored in the future.