bluuebunny/crossref_metadata_2025_split huggingface dataset:
Latitudinal gradient and spatial covariance in species richness of tropical Lepidoptera in the Andes
Authors: Pyrcz Tomasz W. , Willmott Keith , Garlacz Rafał , Boyer Pierre , Gareca Yuvinka 
Published: November 2013

Abstract

We investigated whether Lepidoptera species richness in the tropical Andes is distributed evenly across the latitudinal gradient, explored the spatial correlations between different taxonomic groups, and investigated historical and ecological factors responsible for shaping the observed patterns.

We interpolated species richness from collecting records of nine ecologically diverse taxa of montane Lepidoptera, eight of butterflies (Ithomiini, Acraeini, Callicorini, Pronophilina, Aporiina, Leptophobia, Penaincisalia, and Forsterinaria) and one of moths (Geometridae: Erateina) along elevational transects from 1000 to 3500 m every two degrees in latitude between 11°N and 27°S. We used multiple regression to assess the role of climatic and historical variables in shaping their species richness patterns, and Spearman's correlation coefficient to examine the correlation of species richness gradients between pairs of taxa.

We found that Lepidoptera species richness in the tropical Andes is distributed unevenly across the latitudinal gradient, differing considerably between the least and the most diverse transects, with a peak at 3–11°S, and is strongly correlated among all nine taxa. Geological age of the Andes, area and climatic seasonality explained the most variation in species richness, with age dominating in the north and seasonality in the south.

The latitudinal gradient in east Andean Lepidoptera species richness is likely a result of historical and contemporary factors, in particular temperature seasonality and the greater age of the Andes south of the Equator. Local aspects of species richness patterns are due to small‐scale geological or climatic phenomena, for example, the peak at 3–5°S which results from local mixing of east‐west Andean faunas in the Huancabamba Deflection area.
Silicone oil emulsions: strategies to improve their stability and applications in hair care products
Authors: Nazir H. , Zhang W. , Liu Y. , Chen X. , Wang L. , Naseer M. M. , Ma G. 
Published: November 2013

SynopsisSilicone oils have wide range of applications in personal care products due to their unique properties of high lubricity, non‐toxicity, excessive spreading and film formation. They are usually employed in the form of emulsions due to their inert nature. Until now, different conventional emulsification techniques have been developed and applied to prepare silicone oil emulsions. The size and uniformity of emulsions showed important influence on stability of droplets, which further affect the application performance. Therefore, various strategies were developed to improve the stability as well as application performance of silicone oil emulsions. In this review, we highlight different factors influencing the stability of silicone oil emulsions and explain various strategies to overcome the stability problems. In addition, the silicone deposition on the surface of hair substrates and different approaches to increase their deposition are also discussed in detail.
Regeneration of the dentine–pulp complex with revitalization/revascularization therapy: challenges and hopes
Authors: Lin L. M. , Ricucci D. , Huang G. T.‐J. 
Published: November 2013

AbstractThe concept of regenerative endodontics has gained much attention in clinical endodontics in the past decade. One aspect of this discipline is the application of revitalization/revascularization therapies for infected and/or necrotic immature pulps in permanent teeth. Following the publication of a case report (Iwaya et al. ), investigators have been rigorously examining the types of tissues formed in the canals as well as exploring strategies to regenerate the pulp–dentine complex in revitalized teeth. This review will provide an update on the types of tissues generated in the canals after revitalization/revascularization therapy in both animal and human studies. The understanding of the role of stem cells and microenvironment in the process of wound healing resulting in either regeneration or repair will be thoroughly discussed. Stem cells and microenvironmental cues introduced into the canal during revitalization/revascularization procedures will be examined. In addition, requirement of a sterile microenvironment in the canal and vital tissue generation in revitalization/revascularization therapy will be emphasized. The challenges that we face and the hopes that we have in revitalization/revascularization therapy for regenerative endodontics will be presented.
Crack Growth Monitoring in Ceramic Matrix Composites by Combined Infrared Thermography and Acoustic Emission
Authors: Dassios Konstantinos G. , Kordatos Evangelos Z. , Aggelis Dimitris G. , Matikas Theodore E. 
Published: November 2013

The current study proposes a novel methodology for measuring crack growth in composite materials using combined infrared thermography (IRT) and acoustic emission (AE). The technique is tested across a SiC‐fiber‐reinforced ceramic matrix composite while no apparent factor is limiting its usage on composite materials of different nature as well. Compact tension specimens were loaded in tension with unloading/reloading loops and the thermally dissipated energy due to crack growth and other damage mechanisms was captured by IRT with a 100 Hz sampling rate. Crack growth was established by identifying the time instances where the maximum temperature, hence also damage, occurred and then quantifying, by means of control lines, the damage span within the thermograph corresponding to the specific instance. The high accuracy of the proposed technique was validated against optical measurements of crack length. The theoretical crack length predicted by the elastic compliance technique was found to overestimate the experimental findings by at least 25%. Knowledge of the critical level of damage accumulation for material structural health was made possible from AE descriptors such as activity during the unloading part of the cycles. In this study, AE was particularly successful in closely following the actual crack growth measured by IRT, an observation that brings out the potential of the technique for quantitative measurements.
Predator–prey interactions, flight initiation distance and brain size
Authors: Møller A. P. , Erritzøe J. 
Published: November 2013

AbstractPrey avoid being eaten by assessing the risk posed by approaching predators and responding accordingly. Such an assessment may result in prey–predator communication and signalling, which entail further monitoring of the predator by prey. An early antipredator response may provide potential prey with a selective advantage, although this benefit comes at the cost of disturbance in terms of lost foraging opportunities and increased energy expenditure. Therefore, it may pay prey to assess approaching predators and determine the likelihood of attack before fleeing. Given that many approaching potential predators are detected visually, we hypothesized that species with relatively large eyes would be able to detect an approaching predator from afar. Furthermore, we hypothesized that monitoring of predators by potential prey relies on evaluation through information processing by the brain. Therefore, species with relatively larger brains for their body size should be better able to monitor the intentions of a predator, delay flight for longer and hence have shorter flight initiation distances than species with smaller brains. Indeed, flight initiation distances increased with relative eye size and decreased with relative brain size in a comparative study of 107 species of birds. In addition, flight initiation distance increased independently with size of the cerebellum, which plays a key role in motor control. These results are consistent with cognitive monitoring as an antipredator behaviour that does not result in the fastest possible, but rather the least expensive escape flights. Therefore, antipredator behaviour may have coevolved with the size of sense organs, brains and compartments of the brain involved in responses to risk of predation.
A question of time: Daily time allocation between work and private life
Authors: Unger Dana , Niessen Cornelia , Sonnentag Sabine , Neff Angela 
Published: November 2013

This diary study investigates time allocation between work and private life of dual‐earner couples. Addressing the association between positive and negative experiences in romantic relationships and time spent on work, we test propositions derived from a general control‐theoretical approach. We also study the consequences of time allocation to work and private life for relationship‐oriented needs and goals (i.e., intimacy and social support). A total of 152 persons (i.e., 76 couples), mainly working in academia, took part in our study. Using multilevel path analysis, we found support for the general control‐theoretical approach. Relationship quality was positively and relationship hassles were negatively associated with time spent on work. We found evidence for a trade‐off between time spent on work and relationship time. Relationship time in turn was positively associated with intimacy and social support. In our discussion, we stress the importance of time control in organizations in order to support employees in their daily trade‐off between time spent on work and on the relationship.Practitioner points

We examine daily time spent to work, a variable that is highly important for goal‐pursuit at work and in the private life.

We shed light on resource allocation between work and private life as a self‐regulatory strategy helpful for the simultaneous pursuit of concerns in both life domains.

The outcomes intimacy and social support have relevance for performance and dealing with stress in the work domain.

Valuing and engaging in face time at work is challenged.
Impacts of wearing complete dentures on bolus transport during feeding in elderly edentulous
Authors: Yamamoto H. , Furuya J. , Tamada Y. , Kondo H. 
Published: November 2013

SummaryProsthetic treatment with dentures is often required for the elderly who have reduced swallowing function. Therefore, it is important to understand the relationship between denture‐wearing and feeding function from the perspective of swallowing. To clarify changes in bolus transport during feeding in elderly edentulous patients with or without complete dentures. Subjects were 15 elderly edentulous volunteers who were treated with maxillary and mandibular complete dentures. The test food was 10 g of minced agar jelly containing barium sulphate with a particle diameter of 4·0–5·6 mm. Lateral videofluoroscopy was performed to assess the position of the leading edge of the bolus, the bolus volume in each area at swallow onset, bolus transit time and the mandibular position during pharyngeal swallowing. There were significant changes between the bolus transport with and without dentures. Without dentures, the leading edge of the bolus at swallow onset fell from the valleculae area to the hypopharynx, and the bolus volume in the hypopharynx increased. Bolus transit time increased in the oral cavity, valleculae and hypopharynx. The mandibular position shifted anterosuperior direction. The results arose owing to anatomical changes in the oral and pharyngeal structure and the following functional changes: poor food manipulation, poor bolus formation and delayed swallowing reflex. Removing dentures in elderly edentulous individuals influences bolus transport during feeding, resulting in the exacerbation of the reduced swallowing reserve capacity that accompanies ageing, and may increase the risk of dysphagia.
Using Flory–Huggins phase diagrams as a pre-formulation tool for the production of amorphous solid dispersions: a comparison between hot-melt extrusion and spray drying
Authors: Tian Yiwei , Caron Vincent , Jones David S , Healy Anne-Marie , Andrews Gavin P 
Published: November 2013

Abstract

Objectives
Amorphous drug forms provide a useful method of enhancing the dissolution performance of poorly water-soluble drugs; however, they are inherently unstable. In this article, we have used Flory–Huggins theory to predict drug solubility and miscibility in polymer candidates, and used this information to compare spray drying and melt extrusion as processes to manufacture solid dispersions.

Method
Solid dispersions were prepared using two different techniques (hot-melt extrusion and spray drying), and characterised using a combination of thermal (thermogravimetric analysis and differential scanning calorimetry), spectroscopic (Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction methods.

Key findings
Spray drying permitted generation of amorphous solid dispersions across a wider drug concentration than melt extrusion. Melt extrusion provided sufficient energy for more intimate mixing to be achieved between drug and polymer, which may improve physical stability. It was also confirmed that stronger drug–polymer interactions might be generated through melt extrusion. Remixing and dissolution of recrystallised felodipine into the polymeric matrices did occur during the modulated differential scanning calorimetry analysis, but the complementary information provided from FTIR confirms that all freshly prepared spray-dried samples were amorphous with the existence of amorphous drug domains within high drug-loaded samples.

Conclusion
Using temperature–composition phase diagrams to probe the relevance of temperature and drug composition in specific polymer candidates facilitates polymer screening for the purpose of formulating solid dispersions.
Testosterone with Dutasteride, but Not Anastrazole, Improves Insulin Sensitivity in Young Obese Men: A Randomized Controlled Trial
Authors: Juang Patricia S. , Peng Susan , Allehmazedeh Kambiz , Shah Ansal , Coviello Andrea D. , Herbst Karen L. 
Published: November 2013

Abstract

Introduction
Testosterone (T) administration to men increases T, estradiol (E2), dihydrotestosterone (DHT), and fat-free mass (FFM), and decreases fat mass (FM) but does not consistently improve insulin sensitivity (IS).

Aim
The aim of this study was to examine the effects of T administration in obese, nondiabetic men on body composition and IS, and to determine if inhibition (i) of metabolism of T to E2 with anastrazole or to DHT with dutasteride alters these effects.

Methods
This was a 98-day randomized, double-blind, parallel group, placebo-controlled trial of 57 men, 24–51 year, free T in the lower 25% of normal range (&lt;0.33 nmol/L), body mass index ≥30.0 kg/m2. Subjects were randomized to one of four groups: (i) placebo: gel, pills, and injection; (ii) T/DHT/iE2: T gel, anastrazole, and acyline (gonadotropin releasing-hormone antagonist to suppress endogenous T); (iii) T/iDHT/E2: T gel, dutasteride, and acyline; (iv) T/DHT/E2: T gel, placebo pills, and acyline.

Main Outcome Measures
Main outcome measures are insulin sensitivity as percent change (%Δ) in glucose disposal rates (GDR) from a two-step euglycemic clamp (GDR1 and 2), and %FM and %FFM by dual X-ray absorptiometry scan.

Results
Insulin Sensitivity: %Δ GDR1 differed across groups (P = 0.02, anova) and was significantly higher in the dutasteride (T/iDHT/E2) compared with the placebo and T gel (T/DHT/E2) groups. %ΔGDR2 was higher in the dutasteride (T/iDHT/E2) compared with the anastrazole (T/DHT/iE2) group. Body Composition: T gel alone (T/DHT/E2) or with dutasteride (T/iDHT/E2) significantly increased %FFM (P &lt; 0.05) and decreased %FM (P &lt; 0.05). There was no change in %FFM or %FM after placebo or anastrazole (T/DHT/iE2).

Conclusions
The combination of T plus dutasteride improved body composition and IS while T alone improved body composition but not IS, suggesting that when T is administered to men, reduction to DHT attenuates the beneficial effects of aromatization to E2 on IS but not body composition.
Two decades of genetic profiling yields first evidence of natal philopatry and long‐term fidelity to parturition sites in sharks
Authors: Feldheim Kevin A. , Gruber Samuel H. , DiBattista Joseph D. , Babcock Elizabeth A. , Kessel Steven T. , Hendry Andrew P. , Pikitch Ellen K. , Ashley Mary V. , Chapman Demian D. 
Published: November 2013

AbstractSharks are a globally threatened group of marine fishes that often breed in their natal region of origin. There has even been speculation that female sharks return to their exact birthplace to breed (‘natal philopatry’), which would have important conservation implications. Genetic profiling of lemon sharks (Negaprion brevirostris) from 20 consecutive cohorts (1993–2012) at Bimini, Bahamas, showed that certain females faithfully gave birth at this site for nearly two decades. At least six females born in the 1993–1997 cohorts returned to give birth 14–17 years later, providing the first direct evidence of natal philopatry in the chondrichthyans. Long‐term fidelity to specific nursery sites coupled with natal philopatry highlights the merits of emerging spatial and local conservation efforts for these threatened predators.
yciM is an essential gene required for regulation of lipopolysaccharide synthesis in Escherichia coli
Authors: Mahalakshmi S. , Sunayana M. R. , SaiSree L. , Reddy Manjula 
Published: November 2013

SummaryThe outer membrane of Gram‐negative bacteria is an asymmetric lipid bilayer consisting of an essential glycolipid lipopolysaccharide (LPS) in its outer leaflet and phospholipids in the inner leaflet. Here, we show that yciM, a gene encoding a tetratricopeptide repeat protein of unknown function, modulates LPS levels by negatively regulating the biosynthesis of lipid A, an essential constituent of LPS. Inactivation of yciM resulted in high LPS levels and cell death in Escherichia coli; recessive mutations in lpxA, lpxC or lpxD that lower the synthesis of lipid A, or a gain of function mutation in fabZ that increases the formation of membrane phospholipids, alleviated the yciM mutant phenotypes. A modest increase in YciM led to significant reduction of LPS and increased sensitivity to hydrophobic antibiotics. YciM was shown to regulate LPS by altering LpxC, an enzyme that catalyses the first committed step of lipid A biosynthesis. Regulation of LpxC by YciM was contingent on the presence of FtsH, an essential membrane‐anchored protease known to degrade LpxC, suggesting that FtsH and YciM act in concert to regulate synthesis of lipid A. In summary, this study demonstrates an essential role for YciM in regulation of LPS biosynthesis in E. coli.
How long do louse eggs take to hatch? A possible answer to an age‐old riddle
Authors: BURGESS I. F. 
Published: November 2013

AbstractThere are no rigorous data on how long eggs of the head louse, Pediculus capitis (Phthiraptera: Pediculidae), take to hatch. Pediculicide users often report re‐infestations after apparently successful treatments in the absence of infective contacts. This study aimed to resolve the question of whether some louse eggs hatch after the completion of treatment, thereby giving rise to a new infestation. Data were extracted from the records of lice collected after treatments in 20 clinical intervention trials. All datasets were eliminated except those in which only newly hatched louse nymphs were found prior to the final assessment. This excluded the possibility that new eggs were laid after the first treatment and thus any young lice found must have originated from eggs laid before the start of treatment. This identified 23 of 1895 (1.2%) records with evidence of louse nymphs emerging at 13 days or more after the first treatment, 3–6 days longer than previous estimates. Current treatment regimens for pediculicides of two applications 7–10 days apart appear inadequate, which may explain continuing infestation in the community. Therefore, it is suggested that a revised approach using three treatments applied at intervals of 1 week should prevent the survival of any nymphs and their development into a new generation of adults.
Polymorphic chromosomal inversions in Anopheles moucheti, a major malaria vector in Central Africa
Authors: SHARAKHOVA M. V. , ANTONIO‐NKONDJIO C. , XIA A. , NDO C. , AWONO‐AMBENE P. , SIMARD F. , SHARAKHOV I. V. 
Published: November 2013

AbstractAnopheles moucheti Evans (Diptera: Culicidae) is a major vector of malaria in forested areas of Central Africa. However, few genetic tools are available for this species. The present study represents the first attempt to characterize chromosomes in An. moucheti females collected in Cameroon. Ovarian nurse cells contained polytene chromosomes, which were suitable for standard cytogenetic applications. The presence of three polymorphic chromosomal inversions in An. moucheti was revealed. Two of these inversions were located on the 2R chromosome arm. The homology between the 2R chromosome arms of An. moucheti and Anopheles gambiae Giles was established by fluorescent in situ hybridization of six An. gambiae genic sequences. Mapping of the probes on chromosomes of An. moucheti detected substantial gene order reshuffling between the two species. The presence of polytene chromosomes and polymorphic inversions in An. moucheti provides a new basis for further population genetic, taxonomic and ecological studies of this neglected malaria vector.
Probucol combined with valsartan in immunoglobulin A nephropathy: A multi‐centre, open labelled, randomized controlled study
Authors: Ye Zhiming , Zhang Li , Xu Lixia , Shi Wei , Hu Haitang , Shi Xiaofeng , Zhong Weiqiang , Hou Shuan , Yan Honghong , Zhang Bin , Xia Yunfeng , Wang Wenjian , Feng Zonglin , Wang Liping , Liang Yongzheng 
Published: November 2013

AbstractAimAngiotensin receptor antagonists (ARBs) and anti‐oxidants reduce urinary protein excretion and delay progression of immunoglobulin A (IgA) nephropathy. We investigated the efficacy and safety of probucol (an anti‐oxidant) combined with valsartan (an ARB) on the progression of IgA nephropathy.MethodsPatients with IgA nephropathy (n = 69) were recruited from five centres and randomly assigned to a treatment group (750 mg/day probucol plus 160 mg/day valsartan) or a control group (160 mg/day valsartan) and were followed for 3 years.ResultsAt baseline, the two groups in any measured clinical information were comparable. The primary endpoint (doubling serum creatinine) showed no significant difference between the two groups during 3‐year follow‐up. The secondary endpoint (50% reduction in 24‐h urinary protein) occurred in 23 patients in the treatment group and 20 patients in the control group. The time to the secondary end‐point was shorter in the treatment group than the control group (8.13 months vs 19.63 months, P = 0.019). However, at the 3‐year follow‐up, the 24‐h urinary protein levels were not significantly different from the baseline levels (P = 0.99 and P = 0.66, respectively). At the 1‐year follow‐up, plasma cholesterol in the treatment group was markedly lower than in the control group (4.12 ± 1.28 vs 5.03 ± 1.01, P = 0.02).ConclusionKidney function remained stable and there was no significant difference in two group patients. Probucol combined with valsartan led to a more rapid decrease of 24‐h urinary protein excretion than valsartan alone. However, the long‐term effect needs further investigation.