bluuebunny/crossref_metadata_2025_split huggingface dataset:
Individually tailored ultrasound‐assisted prompted voiding for institutionalized older adults with urinary incontinence
Authors: Iwatsubo Eiji , Suzuki Motofumi , Igawa Yasuhiko , Homma Yukio 
Published: July 2014

ObjectivesTo assess individually tailored ultrasound‐assisted prompted voiding as a means of managing urinary incontinence in hospitalized elderly patients.MethodsA total of 88 incontinent elderly individuals who were inpatients in general hospitals were included. Each individual's mean bladder volume before starting to void (voided urine volume plus residual urine volume) was regarded as the optimal bladder volume. Bladder volume was regularly monitored with an ultrasound device, and when the urine volume had reached the individual's optimal bladder volume, the subject was prompted to void. The outcomes were evaluated on the basis of scores on a four‐grade scale for items in six domains: urine volume, voiding function, urinary control, physical and cognitive function for toileting, and caregivers' burden in regard to continence care. The score for use of a pad/diaper, an item of urinary control domain, was used as the primary outcome measure.ResultsA total of 80 participants were included for analysis. After ultrasound‐assisted prompted voiding care for a 4‐week period, the score for use of a pad/diaper in 50 out of 80 participants (62.5%) had decreased, and 21 out of 80 participants (26.3%) no longer required the use of a pad/diaper at all. The scores of the other 30 out of 80 participants (37.5%) were unchanged. The improvement was not significantly affected by patients' backgrounds at baseline. The mean scores in the domains of urinary control, physical function, cognitive function and caregivers' burden improved significantly.ConclusionThe present preliminary study suggests that individually tailored ultrasound‐assisted prompted voiding can improved urinary incontinence of institutionalized elderly patients. Further studies are worth carrying out.
Comprehensive Analysis of 28 Patients with Latex Allergy and Prevalence of Latex Sensitization among Hospital Personnel
Authors: Mitsuya Kaoru , Iseki Hiromi , Masaki Tomoko , Hamakawa Motoko , Okamoto Hiroyuki , Horio Takeshi 
Published: July 2014

AbstractRecently anaphylactic shock caused by latex gloves and medical instruments has been discussed as an important problem in surgical operations. Patients with contact urticaria or anaphylaxis due to natural rubber latex were first reported in Japan in 1993, and the number of cases is gradually increasing. In the present study, we analyzed 28 patients examined in our clinic from 1993 to 1998. The diagnosis of latex allergy was made on the basis of clinical history, latex specific IgE antibody, skin test, and use test. The 3 male and 25 female patients included 20 nurses, 4 doctors, 2 housewives, one animal hospital employee, and one worker in a senile rehabilitation center. The majority were health care workers. Contact urticaria from rubber gloves was the most common clinical symptom. Some of the patients developed severe attacks of anaphylaxis. During the period from 1995 to 1997, we also performed a questionnaire study and a serum examination of latex specific IgE antibody among the personnel of our university hospital. The screening test for the antibody was more reliable than our questionnaire study in detecting latex‐sensitive persons. The prevalence of latex allergy was found to be 4.6%. This indicates that not only dermatologists but also all hospital workers should be aware of this type of allergy.
Epstein‐Barr Virus‐associated Recurrent Necrotic Papulovesicles with Repeated Bacterial Infections Ending in Sepsis and Death: Consideration of the Relationship between Epstein‐Barr Virus Infection and Immune Defect
Authors: Yoon Tae Young , Yang Tae Ho , Hahn Youn Soo , Huh Joo Ryung , Kim Youn Soo 
Published: July 2014

AbstractThe disease of Epstein‐Barr virus (EBV) ‐associated recurrent necrotic papulovesicles is a distinct clinicopathologic entity different from classic hydroa vacciniforme (HV). A few patients have been reported as atypical HV with systemic involvement, development of lymphoma, and poor prognosis. We describe a patient with recurrent necrotic papulovesicles and multiple varioliform scars in both sun‐exposed and covered areas. In contrast to cases of previously reported atypical HV, our patient suffered from repeated bacterial infections on various sites ending in sepsis and death, but without malignant transformation. EBV was detected in the lymphoid cells from the skin lesions by anti‐latent membrane protein (LMP) antibody and in situ hybridization. We suggest that the repeated bacterial infections in this case raise the possibility of an association of EBV infection with increased susceptibility to bacterial infections.
Extensive Partial Unilateral Lentiginosis
Authors: Romiti Ricardo , Harnache Juan David , Neto Cyro Festa , Kreuter Alexander , Altmeyer Peter , Jansen Thomas 
Published: July 2014

AbstractPartial unilateral lentiginosis is a rare pigmentary disorder characterized by multiple lentigines on otherwise normal skin affecting one side of the body. The histology is that of a lentigo. We report two young men with an extensive form of partial unilateral lentiginosis affecting the skin. No systemic abnormalities could be identified.
An Indian Case of Keratoderma Hereditarium Mutilans (Vohwinkel's Syndrome) Associated with Ichthyosiform Dermatosis
Authors: Vijaikumar Marykolandainathen , Thappa Devinder Mohan , Jeevankumar Balasubramanian 
Published: July 2014

AbstractKeratoderma hereditarium mutilans (KHM) or Vohwinkel's syndrome (VS) is usually inherited as an autosomal dominant disease, but a recessive type has occasionally been described. We report a 19‐year‐old male born to consanguineous parents, who presented with KHM associated with generalized ichthyosiform dermatosis. On examination, his generalized ichthyosiform dermatosis was accompanied by severe ‘honey comb’ like palmoplantar keratoderma and marked hyperhidrosis. Bilateral fifth toes showed complete constricting bands just distal to the metatarsophalangeal joints leading to pseudoainhum. The histopathologic examination of a biopsy from the sole showed hyperkeratosis, marked parakeratosis, hypergranulosis, acanthosis, and a few mononuclear cells in the papillary dermis, consistent with the diagnosis of KHM. Several hereditary disorders may show varying degrees of hyperkeratosis and constriction of digits; their differentiating features are discussed. This case is reported for its rarity and interesting associated findings.
A Case of Pedunculated Malignant Melanoma of the Vaginal Mucosa
Authors: Kimura Chu , Furuya Kazuhiko 
Published: July 2014

AbstractWe report an 84‐year‐old Japanese woman who presented with a pedunculated malignant melanoma of the vaginal mucosa. Mucosal melanoma is believed to be more common in Japan than other countries, but such tumors of the vulvovaginal region are quite unusual. In our patient, three tumors were connected by a narrow pedicle. Three black tumors measuring 5–10 mm in diameter with a common pedicle were seen on the vaginal mucosa at five o'clock from the cervix. The tumors were hanging from the narrow pedicle. On histologic examination, they were diagnosed as malignant melanoma. Resection was done with a distal margin of 3 cm from the tumors and a margin of 1 cm from the cervix. The patient has had no evidence of local recurrence or distant metastasis. In our patient, the three main tumors had a common pedicle, which seems to be a unique finding. Since pedunculated malignant melanomas are rare, making a clinical diagnosis is difficult. Although pedunculated melanomas are recognized as having a high malignant potential because these lesions are generally thick, a relatively good outcome is sometimes reported. In our patient, there was no tumor infiltration into the dermis of the pedicle, and this may be one reason for the good outcome at present. There has been no previous report of a mucosal melanoma consisting of three tumors like those in the present patient.
Unusual Urticarias
Authors: Black Anne Kobza 
Published: July 2014

AbstractTypical urticarial lesions are transient cutaneous swellings of sudden onset, often itchy, persisting for less than 24 hours and resolving to leave normal appearing skin. Angioedema lesions are similar subcutaneous lesions. Atypical urticarias persist for longer than 24 hours, may be painful and bruised in appearance and accompanied with severe systemic symptoms. Conditions where prolonged weals are present include delayed pressure urticaria and urticarial vasculitis. These conditions do not respond well to antihistamine therapy. In delayed pressure urticaria, weals appear after a delay of hours at sites of sustained pressure on the skin and occur in association with ordinary chronic ‘idiopathic’ urticaria. Weals of urticarial vasculitis show histological features of venulitis, and can be accompanied by arthralgia and abdominal pain. Rarely, the condition is due to infective or autoimmune disease. Urticarial diseases, sometimes with features of urticarial vasculitis, and with associated systemic features include Schnitzler's Syndrome, Still's disease and Muckle‐Wells syndrome. The latter syndrome is linked with chromosome 1q44, as is autosomal dominant cold urticaria, an unusual physical urticaria. Persistent cholinergic erythema, a variant of cholinergic urticaria, has been mistaken for a drug eruption or cutaneous mastocytosis. Rarely, food and exercise induced urticaria and anaphylaxis occur when exercise follows a specific food or any meal within a few hours. The early stages of inflammatory disease may be mistaken for urticaria and angioedema, but lesions usually persist for longer than 48 hours and are accompanied by epidermal changes.
100 Years of Japanese Dermatology: A Perspective from Abroad
Authors: Holubar Karl , Fatović‐Ferenčic Stella 
Published: July 2014

AbstractThe development of Japanese dermatology is reviewed from the times of the founding fathers and Keizo Dohi to today. Tribute is paid to the heroes of the first hour. Thereafter, an evaluation of Japanese‐authored papers in the leading journal of the field (JID) over four decades is presented, taking a triennial slot in each. The contribution of Japanese‐authored papers has increased substantially over this period.
Rod‐shaped Bodies Resembling Birbeck Granule‐like Structures in Endothelial Cells of Dermal Capillaries in Generalized Granuloma Annulare
Authors: Kohn Sarah , Friedman‐Birnbaum Rachel 
Published: July 2014

AbstractA previous study demonstrated that, in generalized granuloma annulare in the epidermis, the Langerhans' cell section area and the number of Langerhans' cell granules or Birbeck granules per cell section were increased, suggesting an active state of these Langerhans' cells. Reexamination by transmission electron microscopy of the same tissue, but in samples also containing dermal tissue, from the same subjects revealed endothelial cells with rod‐shaped bodies resembling Birbeck granules or Birbeck granule‐like structures. This finding has not been previously described in blood vessels of human skin and is described here.
A Clinico‐Mycological Study of Dermatophytoses in Nepal
Authors: Agarwalla Arun , Jacob Mary , Sethi Manoj , Parija Subash C. , Singh Narendra P. 
Published: July 2014

AbstractA clinico‐mycological study of 100 cases of dermatophytosis was done in the B.P. Koirala Institute of Health Sciences in the eastern region of Nepal. The incidence of dermatophytoses in this study was 4.54% with a M: F ratio of 2.5: 1. The commonest age group was 11‐20 years old. A single clinical type was found in 68%; 32% had two or more clinical types. The study revealed tinea corporis (43%) as the most common clinical type followed by tinea cruris (33%) and tinea pedis (20%). Positive culture was obtained in 94% of cases. A total of eight different species of dermatophytes were isolated with T. rubrum (45.74%) as the most common species followed by T. mentagrophytes (26.6%), T. tonsurans (11.7%), M. audouinii (8.36%), E. floccosum (4.26%), T. schoenlenii (2.13%), T. violaceum (2.13%) and T. verrucosum (1.06%).
Churg‐Strauss Syndrome with Renal Involvement: A Case Report
Authors: Kitoh Akihiko , Nobuhara Satomi , Takahashi Kenzo , Nishigori Chikako , Miyachi Yoshiki 
Published: July 2014

AbstractWe report a case of Churg‐Strauss syndrome with renal involvement. A 51‐year‐old woman was admitted to our hospital in April of 1999 complaining of abdominal pain and severe diarrhea followed by multiple purpura on both legs. A diagnosis of Churg‐Strauss syndrome was made on the basis of the presence of preceding asthma, eosinophilia, increased IgE, and the histological findings of a biopsy taken from the purpura. Creatinine clearance level at admission was low (43.3 ml/min) and urinalysis revealed proteinuria and microscopic hematuria. These abnormalities were improved with systemic steroid therapy. Renal involvement seems to be more common than previously reported in Churg‐Strauss syndrome.
Malignant Melanoma Cells in the Eccrine Apparatus
Authors: Kiryu Hiromaro , Imayama Shuhei 
Published: July 2014

AbstractA case of malignant melanoma arising on the sole of a 75‐year‐old Japanese man is presented. Histopathologically, in addition to the intraepidermal and intradermal malignant melanoma cells reaching the upper part of the dermis, cells were also found in the deep part of the ductal epithelium of the eccrine apparatus. Melanoma cells, and melanocytic nevus cells as well, are rarely found within the epithelial structure of sweat glands, yet they are frequently found in that of hair follicles. In order to avoid a residue of melanoma cells in the deep part of the eccrine apparatus, a fairly deep excision should be performed even for thin melanoma.
A Case of Cutaneous Disseminated Sporotrichosis
Authors: Liu Xiaoming , Lin Xiran 
Published: July 2014

AbstractWe described a case of cutaneous disseminated sporotrichosis. The condition was diagnosed based on isolation and identification of Sporothrix schenckii from the lesions. The patient was otherwise normal, including a negative HIV test. The blood culture did not grow S. schenckii. However, spores were detected in the biopsy histological sections and stained positively with PAS staining and ConA and LCA lectin histochemistry.
Mucocutaneous Manifestations of Secondary Syphilis in North Indian Patients: A Changing Scenario?
Authors: Kumar Bhushan , Gupta Somesh , Muralidhar Sivaram 
Published: July 2014

AbstractDuring the 1990s, no studies of various clinical presentations of syphilis have been published in the indexed literature. However, a change in the clinical profile of secondary syphilis was expected during the last decade with the rapid spread of the HIV epidemic. The objective was to study the mucocutaneous manifestations of secondary syphilis in patients attending the STD clinic at the Postgraduate Institute of Medical Education & Research Chandigarh, India, during the last decade and to compare them with other similar studies published during the 1980s. All patients who were diagnosed with secondary syphilis in our STD clinic from 1990 to 1999 were examined and investigated. Serological response was measured at 3, 6, 9, 12, and 24 months post‐treatment or until serological negativity was reached. Fifty‐three patients (males=34, female=19) during this period were found to have secondary syphilis. The most common symptoms were as follows‐skin rash 38 (71.7%), lymphadenopathy 26 (49%), persistent chancre 4 (7.5%), nodular syphilides 2 (3.8%), lues maligna 2 (3.8%), patches in the oral mucosa 6 (11.3%), condylomata lata 14 (26.4%), split papules 2 (3.8%). Five patients had a thin and conspicuous genital scar of the healed primary chancre. Three patients were HIV seropositive (1 patient each with lues maligna, lichenoid, and nodular syphilides). With the spread of the HIV epidemic, atypical muco‐cutaneous manifestations of secondary syphilis may be seen more frequently than before and may pose problems in diagnosis. In the present study, six patients had atypical manifestations, and three of them were HIV seropositive.
Gene Therapy
Authors: Badiavas Evangelos V. , Falanga Vincent 
Published: July 2014

AbstractWith recent advances in molecular biology, the ability to transfer genes to patients is becoming a reality. Ongoing clinical trials using gene transfer techniques have illustrated the potential and pitfalls of this new therapeutic modality for the treatment of a wide variety of disorders. While these techniques are not currently a part of routine clinical practice, it is only a matter of time until some form of gene therapy is approved for general use in the clinic. This review highlights some of the basic methods used in current gene therapy protocols. The objective of this review is to familiarize practitioners with these concepts so they can more effectively follow the progress of this emerging technology and better inform their patients.
Degenerated Neurilemoma (Ancient Schwannoma)
Authors: Ishihara Tsuyoshi , Ono Tomomichi 
Published: July 2014

AbstractWe report a case of degenerated neurilemoma in a 65‐year‐old Japanese woman. A tumor in the right thigh histopathologically showed a mixture of Antoni type A and B patterns, and contained prominent blood vessels with hyalinized walls, but no calcification. The tumor cell nuclei of middle areas were large, hyperchromatic and often multilobed but lacked mitotic figures. The mucinous areas had few tumor cells. Antoni type A and B areas were S‐100 protein positive, while mucinous areas and hyalinized vessels were negative.
Palpable Purpura at the Site of Previous Herpes Zoster in Association with Mixed Cryoglobulinemia and Hepatitis C Virus Infection
Authors: Cecchi Roberto , Giomi Andrea , Paoli Simone 
Published: July 2014

AbstractA 70‐year‐old woman affected with chronic active hepatitis C and mixed cryoglobulinemia presented a palpable purpura on her abdominal skin in a metameric configuration, fourteen months after a herpes zoster in the same site. Histopathology showed a small vessel leukocytoclastic vasculitis in the superficial dermis. Post‐zoster eruptions are variable, and their spectrum is still expanding, although the pathogenesis remains to be elucidated. Perhaps our case represents an isomorphic reaction, because this palpable purpura, probably related to HCV infection, occurred several months after herpes zoster.
Calciphylaxis in a Patient with End‐Stage Renal Disease
Authors: Kim Young‐Jo , Chung Byoung‐Soo , Choi Kyu‐Chul 
Published: July 2014

AbstractCalciphylaxis is a rare and life‐threatening condition of progressive cutaneous necrosis secondary to small and medium‐sized vessel calcification. It is seen almost exclusively in patients with end‐stage renal disease and secondary hyperparathyroidism. We experienced a case of 67‐year‐old man with calciphylaxis that manifested with characteristic skin lesions, pathologic findings, and laboratory changes. His skin lesions began as painful erythematous patches and subsequently progressed to necrotic ulcers with eschars on the distal aspect of the extremities. Pathologically, calcification was found in small and medium‐sized blood vessels in the deep dermis and subcutaneous tissue. His serum calcium was 9.5 mg/dL, phosphorus was 7.8 mg/dL, and nPTH was 99.9 pg/mL. The patient had been treated with surgical debridement and other supportive treatment. However, he eventually underwent an amputation below the right knee and died from sepsis.
Desmosomes: Structure and Function in Normal and Diseased Epidermis
Authors: McMillan James R. , Shimizu Hiroshi 
Published: July 2014

AbstractDesmosomes are important epidermal adhesion complexes that are characterized by a cell‐specific expression of transmembrane cadherins and plaque‐associated molecules. Desmosomes have so far, been implicated in three main disease types: autoimmune diseases that involve desmosome components (such as pemphigus vulgaris and pemphigus foliaceus), congenital diseases that affect intracellular calcium channels (such as Hailey‐Hailey disease and Darier disease) and congenital diseases that directly affect desmosomal structural components. The identification of the first congenital defect affecting a desmosome component was in the gene for plakophilin 1 which caused an autosomal recessive skin fragility‐ectodermal dysplasia syndrome with skin, hair and nail defects. Subsequently, either a haploinsufficiency of desmoplakin or a defect in desmoglein 1 was found to underlie the autosomal dominant condition Striate Palmoplantar Keratoderma. In addition, plakoglobin has been shown to be defective in Naxos disease, which results in a cardiomyopathy and growth of abnormal hair. These findings pave the way for the discovery of further cell cohesion‐related diseases and will help to greatly increase our understanding of the specific function of desmosome and other epithelial junction components.
Sentinel Lymph Nodes Study in 30 Cases of Melanoma
Authors: Ishihara Tsuyoshi , Nakamura Atsushi , Kageshita Toshiro , Ono Tomomichi 
Published: July 2014

AbstractIn 30 cases of melanoma, we attempted to detect sentinel lymph nodes using 1–2% patent blue dye and were able to detect them in 27 cases (90%): 19 cases out of 21 cases in the groin area (90%), 5 out of 5 cases in the axilla area (100%), and 3 out of 4 cases in the neck area (75%). The numbers of sentinel lymph nodes were one in 16 cases, two in 7 cases, three in 2 cases, and four in 2 cases. The cases with three and four nodes were all in the groin area. In 22 cases, tumor metastasis was negative in sentinel lymph nodes. Sentinel lymph nodes were detected in 36 out of 174 samples, and tumor metastasis was negative except in these sentinel lymph nodes (false negative 0%). In the groin area, sentinel lymph nodes were located around the femoral and great saphenous vein junction. In the axilla area, sentinel lymph nodes were located in the central, lateral and subscapular lymph nodes. In the head and neck area, sentinel lymph nodes were found in the submandibular and occipital lymph nodes. The positions of sentinel lymph nodes differed a little with tumor location. By accumulating cases, it should become possible to predict the positions of sentinel lymph nodes before operations. Sentinel lymph node biopsy is easy and requires only a small incision.
Analysis of the Vascularity of an Atelocollagen Sponge Substitute Dermis in the Human
Authors: Ishihara Tsuyoshi , Ono Tomomichi 
Published: July 2014

AbstractAtelocollagen sponge had been developed as a new beneficial dermal substitute. However, histologic studies of the vascularity of an atelocollagen sponge substitute dermis in humans are very rare. The purpose of this study was to determine the distribution of blood vessels in an artificial dermis made of atelocollagen affixed to human tissue. The artificial dermis was used in 21 cases and at 23 sites, and biopsies were performed. The samples were stained with anti‐human blood type A, B, and H monoclonal antibodies. Angiogenesis in the upper layer of the artificial dermis was recognizable within 14 days after affixing the artificial dermis. We concluded that a skin graft taken 14 days after affixing the artificial dermis would be successful, even though the granulation tissue formation might not be completed and the color would most likely remain white. The lower layer of the angiogenesis spread in a horizontal direction like an expanded network of blood vessels, while the middle and upper layers of angiogenesis spread perpendicularly to form upward growth when two cases were examined in various spots. The data suggested that the sponge construction of artificial dermis not only became a scaffold for the invasion of collagen, but it also facilitated construction of near normal dermis with regard to the construction of blood vessels.