bluuebunny/crossref_metadata_2025_split huggingface dataset:
A new paradigm in facial reanimation for long-standing palsies?
Authors: Ahuja Rajeev B. , Chatterjee Pallab , Gupta Rajat , Shrivastava Prabhat , Gupta Gaurav K. 
Published: April 2015

ABSTRACT
Background: A chance observation of return of excellent facial movement, after 18 months following the first stage of cross-face nerve grafting, without free functional muscle transfer, in a case of long-standing facial palsy, lead the senior author (RBA) to further investigate clinically. Patients and Methods: This procedure, now christened as cross-face nerve extension and neurotization, was carried out in 12 patients of very long-standing facial palsy (mean 21 years) in years 1996-2011. The mean patient age and duration of palsy were 30.58 years and 21.08 years, respectively. In patients, 1-5 a single buccal or zygomatic branch served as a donor nerve, but subsequently, we used two donor nerves. The mean follow-up period was 20.75 months. Results: Successive patients had excellent to good return of facial expression with two fair results. Besides improved smile, patients could largely retain air in the mouth without any escape and had improved mastication. No complications were encountered except synkinesis in 1 patient. No additional surgical procedures were performed. Conclusion: There is experimental evidence to suggest that neurotization of a completely denervated muscle can occur by the formation of new ectopic motor end plates. Long-standing denervated muscle fibres eventually atrophy severely but are capable of re-innervation and regeneration, as validated by electron microscopic studies. In spite of several suggestions in the literature to clinically validate functional recovery by direct neurotization, the concept remains anecdotal. Our results substantiate this procedure, and it has the potential to simplify reanimation in longstanding facial palsy. Our work now needs validation by other investigators in the field of restoring facial animation.
Los sitios web como servicios de información al ciudadano: un estudio sobre los 308 ayuntamientos de Portugal
Authors: Cardoso de Miranda Eduardo Alfredo , Muñoz Cañavate Antonio 
Published: April 2015

Las Administraciones Públicas han establecido desde la aparición de Internet nuevas forma de comunicación, a través de los portales web, para gestionar la información que generan y que es de interés al ciudadano. Estos portales pueden formar parte de sistemas de información de las Administraciones, en los que se gestiona tanto la información interior (back-office) como la información que se lanza al exterior (front-office), y han abierto un nuevo ámbito de trabajo para los profesionales de la información, y de investigación para el ámbito académico.El estudio que se presenta en este trabajo es resumen de una amplia tesis doctoral presentada en 2012 que ha analizado con detenimiento los servicios de los portales web en Internet de los ayuntamientos de los 308 municipios de Portugal. Son los servicios de información, los servicios de comunicación y los servicios de transacción, aplicados a tres ámbitos: vida cotidiana, administración a distancia y participación política.
Surgery-Related Considerations in Treating People Who Use Cannabis
Authors: Mims Mark M. , Parikh Aniruddha C. , Sandhu Zainab , DeMoss Noah , Mhawej Rachad , Queimado Lurdes 
Published: August 2024

ImportanceCannabis use has experienced substantial growth. Many patients treated by otolaryngologists are using cannabis in various forms, often without the knowledge of the treating surgeon. These cannabinoid substances have various systemic effects, and it is critical for otolaryngologists to recognize how cannabis use may contribute to a patient’s care.ObservationsCannabis use has effects that contribute to every phase of a surgeon’s care. Preoperative counseling for tapering use may prevent increased rates of adverse effects. Care with anesthesia must be observed due to increased rates of myocardial ischemia, higher tolerance to standard doses, and prolonged sedation. Although results of studies are mixed, there may be an association with cannabis use and postoperative pain, nausea, and vomiting. Postoperative wound healing may be improved through the use of topical cannabinoids. Significant drug-drug interactions exist with cannabis, most notably with several common anticoagulant medications. Care should be exercised when managing medications for people who use cannabis. While many people who use cannabis consume it infrequently, a substantial population has developed cannabis use disorder, which is associated with increased morbidity and mortality postoperatively. Screening for cannabis use disorder is important and can be done through short screening tools.Conclusions and RelevancePatients who use cannabis may require special attention regarding preoperative counseling and workup, intraoperative anesthesia, postoperative pain management, nausea, wound healing, and drug-drug interactions. As patient use continues to increase, otolaryngologists will find an increasing need to remain up to date on how cannabis use contributes to patient care.
Bioelectrical Impedance Vectors Analysis of Sarcopenic Older Adults Submitted to a Resistance Training Program
Authors: Quizzini Giovanni Henrique , Pereira Caroline Galan de Souza , dos Santos Vanessa Ribeiro , Batista Vitor Cabrera , Silva Bruna Spolador de Alencar , Lira Fábio Santos , Ribeiro Alex Silva , Gobbo Luís Alberto 
Published: August 2024

AbstractThe objective of the present study is to analyze the changes in bioimpedance vector analysis (BIVA) and phase angle (PhA) in sarcopenic older people submitted to a 12‐week resistance training (RT) program according to classic and specific analyses. To this end, 20 sarcopenic older adults of both sexes, invited through media, underwent bioimpedance analysis before and after the RT carried out three times a week, for 12 weeks. The mean impedance vectors of the groups established for the confidence ellipses (95% of the confidence ellipse) are compared using Hotelling's T2 test. The distance D from Mahalanobis is also calculated. Classic and Specific BIVA are presented. The resistance values for the classical analyses (R/H) decreased across all groups (whole group, women and men, p < 0.05), with approximate decreases ranging from 9.4% to 10%, while the classic reactance (Xc/H) decreased (p < 0.05) only for the whole group (5.9%) and men (7.7%). For the specific BIVA, trends are verified for the whole sample, with a decrease in resistance (R.sp) and an increase in reactance (Xc.sp). In conclusion, the RT program in sarcopenic individuals promoted a reduction in resistance values in classical analyses, indicating a possible increase in hydration status and, consequently, musculoskeletal mass.
Two Birds with One Stone: Guanidyl Carbon Dots with Enhanced Antioxidative and Lipolytic Functions in Metabolic Associated Fatty Liver
Authors: Cai Hao , Li Yan , Wu Xiaoyan , Yang Yuxiang , Tedesco Antonio Claudio , Li Zijian , Bi Hong 
Published: August 2024

AbstractMetabolic‐associated fatty liver disease (MAFLD) has become one of the most widespread metabolic diseases nowadays, while no definitive agent is approved for practical treatment. Given excessive lipid deposition and cellular oxidative stress are two main inducers of MAFLD, developing synergistic therapeutic agents that enhance lipid metabolism and antioxidative ability are effective routes for MAFLD therapy. Herein, a novel kind of bio‐functional carbon dots (MTCDs) derived from metformin and tea polyphenols based on a fused pharmacophore strategy is developed. The surface of MTCDs retains abundant phenolic hydroxyl and guanidine groups, which are designed to reduce both lipid deposition and oxidative stress in the liver. Moreover, by finely controlling the surface charge, MTCDs exhibit excellent lysosome targeting functionality with favorable biocompatibility and low biotoxicity. Mechanistical studies further reveal that MTCDs treatment protects lysosomes from oxidative stress damage and activates hepatocyte AMP‐activated protein kinase signaling, which initiates lipophagy progress to accelerate lipolysis and lipid consumption. Collectively, these studies propose an effective “two birds with one stone” tool for MAFLD synergistic therapy and suggest a viable strategy for multi‐pharmacophore agent development.
MOF‐818 Nanozyme Suppresses Calcium Oxalate Kidney Stones by Alleviating Oxidative Stress and Inflammatory Injury
Authors: Tian Yuan , Ye Ziyu , Wang Xunrui , Guan Hantian , Liu Weifeng , Duan Xiaolu , Liu Yang , Zeng Guohua , Liu Hongxing 
Published: August 2024

AbstractThere remains a lack of effective drugs to alleviate the kidney stones caused by oxidative stress and inflammatory damage. The MOF‐818 nanozyme is utilized to lessen the generation of reactive oxygen species (ROS) effectively, restore the membrane potential of mitochondria, regulate the cell cycle, decrease cell death, hinder the recruitment of macrophages, and mitigate the release of inflammatory factors in macrophages. These effects are attributed to the nanozyme's ability to mimic the enzyme properties of catalase (CAT) and superoxide dismutase (SOD). It is demonstrated that this nanozyme can reduce kidney calcium oxalate crystal deposition by reducing the renal injury caused by high concentration oxalate, upregulate the expression levels of SOD and CAT in tissues, downregulate adhesion proteins and inflammatory factor IL‐6 and TNF‐α, and promote the polarization of macrophages from M1 to M2 phenotype in the rat model induced by ethylene glycol. Overall, MOF‐818 has the potential to effectively suppress oxidative stress and inflammatory harm caused by high levels of oxalate, hence lowering the likelihood of stone formation. MOF‐818 nanozyme is also expected to be used as an alternative drug for the treatment of calcium oxalate kidney stones and provide an experimental theoretical basis for the development of new nanomedicines.
Synthesis of Heteromorphic Bi2WO6 Films With an Interpenetrate 1D/2D Network Structure for Efficient and Stable Photocatalytic Degradation of VOCs
Authors: Chen Yuehui , Zhang Liang , Chen Shuo , Sun Songmei , Cheng Hui , Li Shouzhu , Yu Jianyong , Ding Bin , Yan Jianhua 
Published: August 2024

Abstract2D layered Bi2WO6 (BWO) is a widely used attractive photocatalyst for degrading VOCs, but the low visible‐light utilization and the easy stacking 2D nanosheets (NSs) limit photocatalysis efficiency and stability. Here, inspired by Eucalyptus, a synergistic strategy of multiscale domain‐confinement and electrostatic force action, based on electrospinning is proposed, for fabricating a heteromorphic BWO photocatalyst. It is found that BWO NSs can grow radially in an orderly spaced arrangement along BWO nanofibers (NFs) during sintering, thereby forming 1D/2D BWO junctions like eucalyptus leaves. This interpenetrating 1D/2D network structure not only solves the easy stacking problem of BWO NSs but also selectively exposes the {010} crystal planes that exhibit efficient hole oxidation. In addition, this peculiar structure enriches electrons at the 1D/2D interface to avoid carrier recombination, thus improving the photocatalytic activity. The photocatalyst material with a reduced bandgap width from 2.56 to 2.49 eV can rapidly degrade 100% of acetaldehyde under visible light without using sacrificial agents and photosensitizers and shows superior stability for eight cycles without any decay. This study provides a feasible method to synthesize an efficient and stable BWO photocatalyst.
Excitation Wavelength Dependent Fluorescence and Phosphorescence from Organic Ionic Crystalline Powder
Authors: Gong Qi , Dai Xianyin , Yuan Chunhao , Li Jinwei , Zhang Yipeng , Zhang Jiesen , Ge Yanqing 
Published: August 2024

AbstractA new type of material, organic salts in the crystal and crystalline powder state, with both excitation wavelength dependent (Ex‐De) fluorescence and Ex‐De phosphorescence under ambient conditions have been reported. The single component triphenylsulfonium chloride displays tunable fluorescent colors ranging from light purple to sky blue and tunable afterglow colors varying from green to yellowish green, to yellow (lifetimes: 57, 141, 66 ms, afterglow lasting for 2.1, 2.0, 2.3 s). The relationship between the structure and luminescence performance of 17 sulfonium salt derivatives confirms the pivotal roles of both the anions and the electronic and steric effect of substituent factors for luminescence. Single‐crystal analysis reveals that unique ionic bonding and intermolecular interaction can promote an ordered arrangement of organic salts in a crystal state, which then can facilitate molecular aggregation for phosphorescence generation. Theoretical calculations have also confirmed this viewpoint. More importantly, these sulfonium salt derivatives can be used for advanced multimodal anti‐counterfeiting and mitochondrial imaging, respectively. This study has not only expanded the scope of Ex‐De materials but also extended their applications.
Palladium‐Catalyzed Cross‐Coupling between Alkylidenecyclopropanes and Boronic Acids
Authors: Rodiño Ricardo , Mardones Fernando , Paredes Krishna , Jiménez Claudio A. , Nelson Ronald , Mascareñas José L. , López Fernando , Verdugo Felipe 
Published: August 2024

AbstractThe combination of a Pd(0) source and a phosphoramidite ligand promotes a formal allylic cross‐coupling between alkylidenecyclopropanes (ACPs) and boronic acids to yield synthetically appealing 1,1‐disubstituted alkenes. Remarkably, the reaction proceeds both under neutral and basic conditions, and works with both aryl‐ and alkenylboronic acids. DFT calculations suggest that the reaction entails a C−C activation/protonation mechanism instead of a hydropalladation pathway, which has been frequently proposed for other metal‐promoted hydrofunctionalizations of ACPs.
Molecular Synergistic Effect for High Efficiency Monolithic Perovskite/Perovskite/Silicon Triple‐Junction Tandem Solar Cells
Authors: Ye Tianshi , Qiao Liang , Wang Tao , Wang Pengshuai , Zhang Lin , Sun Ruitian , Kong Weiyu , Xu Menglei , Yan Xunlei , Yang Jie , Zhang Xinyu , Ma Linlin , Yang Xudong 
Published: August 2024

AbstractPerovskite/perovskite/silicon triple‐junction tandem solar cells (TSCs) hold promise for high power conversion efficiencies (PCE). However, the efficiency is still relatively low due to the non‐radiative recombination losses in wide‐bandgap top cells. These losses, attributed to the interface defect states and energy level mismatches, present considerable challenges to realizing high‐performance and stable TSCs. Here, the molecular synergistic effect (MSE) is exploited to passivate interface in 1.95 eV top cells. Piperazine‐1‐carboxamide hydrochloride (PCACl) is combined, which possesses strong dipole moments and passivating functional groups that can bind with two neighboring uncoordinated lead ions and form hydrogen bonds with halide atoms at perovskite surface, with 1,3‐propane‐diammonium iodide, which can reduce interface recombination through field‐effect passivation. The MSE enabled by PCACl and PDAI2 facilitates excellent energy level alignment and reduces non‐radiative recombination losses and light‐induced phase segregation. Finally, the target perovskite/perovskite/silicon triple‐junction TSC obtains an open‐circuit voltage of 3.07 V and a champion PCE of 25.2% (for a 1.035 cm2 aperture area).
Versatile and efficient fabrication of signal “turn‐on” lateral flow assay for ultrasensitive naked eye detection of small molecules based on self‐assembled fluorescent gold nanoclusters‐antigen aggregates
Authors: Chao Mengjia , Tai Shengmei , Mao Minxin , Cao Wenbo , Peng Chifang , Ma Wei , Feng Yongwei , Wang Zhouping 
Published: August 2024

AbstractFluorescence signal “turn‐on” lateral flow immunoassay (FONLFA) through nanomaterial labeled quenching fluorescent nanomaterial has shown significant potential for the detection of small molecules. However, the fluorescent nanomaterial immobilization on nitrocellulose (NC) membrane commonly requires tedious chemical modification and only a few combinations of fluorescence donor and quencher have been applied in FONLFA. In this work, bright fluorescent metal nanoclusters (Prot‐AuNCs) were prepared and self‐assembled into Prot‐AuNCs/antigen aggregates with three typical small molecule antigens, respectively. The aggregates can be readily immobilized on the surface of the NC membrane, indicating that this strip fabrication strategy has good versatility. Moreover, we evaluated the performances of this FONLFA platform by using carbendazim as a model target and investigated four typical nanomaterials as colorimetric nanoprobes and fluorescence quenchers. We found that all the nanoprobes demonstrated significantly improved naked eye detection sensitivity (vLOD) and limits of detection (LODs) in quantitative analysis. Among them, combing the Fe‐polydopamine nanoparticles as quencher with the above aggregates, the FONLFA in signal “turn‐on” mode achieved 200‐fold improved vLOD (0.05 ng mL−1) compared with conventional colorimetric AuNPs‐based lateral flow immunoassay (AuNPs‐LFA) (10 ng mL−1). In addition, the LOD in quantitative analysis also was improved by 22‐fold and the whole test process was completed within 10 min. With the advantages of efficient fabrication, extraordinary sensitization, and good biocompatibility, our FONLFA platform is expected to have great potential in the rapid detection of various small molecules.
CT1812 biomarker signature from a meta‐analysis of CSF proteomic findings from two Phase 2 clinical trials in Alzheimer's disease
Authors: Lizama Britney N. , Williams Claire , North Hilary A. , Pandey Kiran , Duong Duc , Di Caro Valentina , Mecca Adam P. , Blennow Kaj , Zetterberg Henrik , Levey Allan I. , Grundman Michael , van Dyck Christopher H. , Caggiano Anthony O. , Seyfried Nicholas T. , Hamby Mary E. 
Published: August 2024

AbstractINTRODUCTIONCT1812 is in clinical development for the treatment of Alzheimer's disease (AD). Cerebrospinal fluid (CSF) exploratory proteomics was employed to identify pharmacodynamic biomarkers of CT1812 in mild to moderate AD from two independent clinical trials.METHODSUnbiased analysis of tandem‐mass tag mass spectrometry (TMT‐MS) quantitative proteomics, pathway analysis and correlation analyses with volumetric magnetic resonance imaging (vMRI) were performed for the SPARC
cohort (NCT03493282). Comparative analyses and a meta‐analysis with the interim SHINE cohort (NCT03507790; SHINE‐A) followed by network analysis (weighted gene co‐expression network analysis [WGCNA]) were used to understand the biological impact of CT1812.RESULTSCT1812 pharmacodynamic biomarkers and biological pathways were identified that replicate across two clinical cohorts. The meta‐analysis revealed novel candidate biomarkers linked to S2R biology and AD, and network analysis revealed treatment‐associated networks driven by S2R. DISCUSSIONEarly clinical validation of CT1812 candidate biomarkers replicating in independent cohorts strengthens the understanding of the biological impact of CT1812 in patients with AD, and supports CT1812's synaptoprotective mechanism of action and its continued clinical development.Highlights
This exploratory proteomics study identified candidate biomarkers of CT1812 in SPARC (NCT03493282)
Comparative analyses identified biomarkers replicating across trials/cohorts
Two independent Ph2 trial cohorts (SPARC and interim SHINE [NCT03507790; SHINE‐A]) were used in a meta‐analysis
Amyloid beta (Aβ) & synaptic biology impacted by CT1812 and volumetric magnetic resonance imaging (vMRI) treatment‐related correlates emerge
Network analyses revealed sigma‐2 receptor (S2R)‐interacting proteins that may be “drivers” of changes
Tricyanmethan oder Dicyanketenimin – Silylierung macht den Unterschied
Authors: Surkau Jonas , Bresien Jonas , Michalik Dirk , Schulz Axel 
Published: August 2024

AbstractPseudohalogenide wie Tricyanmethanid, [C(CN)3]−, sind in der Chemie sowie Biochemie weit verbreitet. Die protonierte Spezies HC(CN)3, eine klassische Pseudohalogen‐Wasserstoff‐Brønsted‐Säure, ist eine sehr starke Säure mit einem pKS‐Wert von −5. HC(CN)3 ist jedoch schwer zu handhaben, da es dazu neigt, sich schnell zu zersetzen oder – genauer gesagt – zu oligo‐ und polymerisieren. Daher sind silylierte Pseudohalogenid‐Verbindungen mit dem [Me3Si]+ als „großem metallorganischen Proton“ von Interesse, die ähnliche chemische Eigenschaften, aber eine bessere kinetische Stabilisierung aufweisen. Hier wird von der schrittweisen Silylierung des Pseudohalogenid‐Anions [C(CN)3]− berichtet, wobei das schwerere Homolog von HC(CN)3, nämlich [Me3Si][C(CN)3], und in Gegenwart von zwei zusätzlichen [Me3Si]+‐Kationen sogar die dikationische Spezies [(Me3Si−NC)3C]2+ als stabiles [B(C6F5)4]‐Salz gebildet wird. Überraschenderweise erfolgt im Gegensatz zur protonierten Spezies HC(CN)3, bei der das Proton an das zentrale C‐Atom von [C(CN)3]− gebunden ist, die Silylierung des [C(CN)3]−‐Anions an einem der drei terminalen N‐Atome, wodurch das lange gesuchte Dicyanketenimin [Me3Si−NC−C(CN)2] gebildet wird. Alle weiteren Silylierungsschritte finden ausschließlich an den terminalen N‐Atomen der drei CN‐Gruppen und nicht am zentralen C‐Atom statt, bis schließlich das bis dato unbekannte, hochsymmetrische Dikation, [(Me3Si−NC)3C]2+, gebildet wird. Die experimentellen Daten werden durch quantenchemische Berechnungen in Bezug auf Thermodynamik und chemische Bindungen unterstützt.
Programmable In‐Situ Co‐Assembly of Organic Multi‐Block Nanowires for Cascade Optical Waveguides
Authors: Zhao Shuai , Zhang Jia‐Xuan , Xu Chao‐Fei , Ma Yingxin , Luo Jia‐Hua , Lin Hongtao , Shi Yingli , Wang Xue‐Dong , Liao Liang‐Sheng 
Published: August 2024

AbstractOrganic heterostructures (OHs) with multi‐segments exhibit special optoelectronic properties compared with monomeric structures. Nevertheless, the synthesis of multi‐block heterostructures remains challenging due to compatibility issues between segment parts, which restricts their application in optical waveguides and integrated optics. Herein, we demonstrate programmable in‐situ co‐assembly engineering, combining multi‐step spontaneous self‐assembly processes to promote the synthesis of multi‐block heterostructures with a rational arrangement of three or more segments. The rational design of segments enables exciton manipulation and ensures optical waveguides and proper output among the multi‐segment OHs. This work enables the controllable growth of segments within multi‐block OHs, providing a pathway to construct complex OHs for the rational development of future optical applications.
3‐Arylcoumarin Scaffolds From 3‐Chlorocoumarin and Arylboronic Acids via Site‐Selective CCl Bond Activation With Palladium Complexes of N∩O Chelating Hydrazones
Authors: Shalini C. , Akilesh M. , Sathiyaraj G. , Bhuvanesh N. S. P. , Neethu K. S. , Kaveri M. V. , Dharmaraj N. 
Published: August 2024

ABSTRACTUsing palladium hydrazone complex as a homogeneous catalyst for SMC, we synthesized a library of 15 variant 3‐arylcoumarins. In this context, we report a set of four coordinated palladium(II) hydrazone complexes 1 and 2 having the general formula [Pd(L)(Cl)(PPh3)] by reacting the precursor complex [PdCl2(PPh3)2] with the hydrazone ligands HL1 or HL2. Single crystal XRD and conventional spectroscopic techniques were employed to characterize both complexes. From the catalytic application point of view, the new complexes 1 and 2 were tested as homogeneous catalysts towards the conversion of 3‐chlorocoumarins into 3‐arylcoumarins by activating the challenging CCl functionality. A minimal catalyst loading of complex 2 (0.01 mol%), afforded a series of 3‐arylcoumarins with a maximum of 92% yield and reusability up to five cycles. The present methodology is simple and easy to carry out at room temperature utilizing a green solvent (ethanol) in an open flask with a spectrum of aryl boronic acids.