bluuebunny/crossref_metadata_2025_split huggingface dataset:
Combined Oral Contraceptives for Polycystic Ovary Syndrome: Pro and Contra (Review)
Authors: Mazerkina I. A. , Davydov I. G. , Alyautdina O. S. 
Published: July 2024

INTRODUCTION. Polycystic ovary syndrome (PCOS) is the main cause of female infertility. Clinical practice guidelines on PCOS recommend combined oral contraceptives (COCs) as first-line therapy. Given the association of PCOS with a number of clinical conditions, including obesity, type 2 diabetes mellitus, metabolic syndrome, anxiety and depressive disorders, an increased risk of endometrial cancer, and cardiovascular diseases, it is important to describe and systematise data on the benefits and risks associated with COCs.AIM. This study aimed to review current data on the use of COCs in PCOS, focusing on the rationality of prescribing, the main risks of using COCs, and the measures to minimise these risks.DISCUSSION. Hirsutism is the most prominent clinical manifestation of hyperandrogenism; in PCOS, its prevalence is 65–75%. COCs containing progestins with anti-androgenic properties are effective in treating hirsutism and superior to anti-androgens alone. Women with PCOS are at increased risk of endometrial cancer due to prolongation of the oestrogen-dependent proliferative phase. This risk can be mitigated by the normalising effect of COCs on the menstrual cycle and the effect of the progestin component of COCs. This review highlights the controversial nature of data on the association of COCs with emerging or exacerbating mental disorders, impaired glucose tolerance, and arterial hypertension/other cardiovascular risks in PCOS. Since the main safety issue with COCs is their thrombogenicity, clinicians should take special care when prescribing medicinal products from this group to PCOS patients. Data on the effect of COCs on fertility in women with PCOS are limited, but there is published evidence of an adverse effect of long-term use of COCs on the results of assisted reproductive technologies.CONCLUSIONS. The key benefit of the non-contraceptive use of COCs in PCOS is in treating hyperandrogenism, mainly hirsutism. To achieve effect, the patient should take COCs containing progestins with anti-androgenic properties for at least 6 months. PCOS patients can also use COCs for contraception. Clinicians prescribing COCs to women with PCOS should consider the individual patient context, the aim of treatment, and any potential risks associated with COCs.
Determination of Elemental Impurities in Gelatine Capsules by Inductively Coupled Plasma Mass Spectrometry
Authors: Shchukin V. M. , Kuz’mina N. E. , Matveeva O. A. , Shvetsova Yu. N. , Zhigilei E. S. 
Published: July 2024

INTRODUCTION. Gelatine capsules are an essential dosage form used for many medicinal products. Gelatine capsules are subject to quality control in accordance with the requirements of the general monograph on capsules of the State Pharmacopoeia of the Russian Federation. This monograph does not standardise the content of elemental impurities, as these impurities are controlled at the raw material level. However, the equipment and excipients used in the production of gelatine capsule shells may be additional sources of impurities. Preliminary screening for chemical elements will help to assess the need for limiting elemental impurities in gelatine capsule shells.AIM. This study aimed to identify the chemical elements that contribute to gelatine capsule shell contamination the most by inductively coupled plasma mass spectrometry, to list the elements requiring specification, and to limit their content from a risk-based pharmaceutical quality control perspective.MATERIALS AND METHODS. The study used 18 samples of hard gelatine capsules by different national and international manufacturers. The elemental analysis was performed using an Agilent 7900 inductively coupled plasma mass spectrometer (Agilent Technologies).RESULTS. The As, Ba, Co, Cr, Cu, Li, Mo, Ni, Pb, Sb, and V content in gelatine capsule shells did not exceed the permitted daily exposure (PDE) thresholds for oral dosage forms specified in the State Pharmacopoeia of the Russian Federation. Ag, Au, Cd, Hg, Ir, Os, Pd, Pt, Rh, Se, Sn, or Tl were not detected in any of the samples within the established detection limits. The Fe content in 67% of the tested shell samples was above the safety-based PDE for medical gelatine.CONCLUSIONS. The greatest contributors to gelatine capsule shell contamination are Al, Fe, and Zn. The lack of established PDE thresholds for these elements presents a challenge in assessing the risks of adverse effects associated with ingesting these elements with gelatine capsules.
Endothelial functional status in patients with a comorbid course of metabolic dysfunction­­­­associated steatotic liver disease and arterial hypertension
Authors: Zhelezniakova N. M. , Aleksandrova T. M. , Molodan V. I. , Panchenko G. Y. 
Published: July 2024

Objective — to investigate endothelial functional state in patients with a comorbid course of metabolic dysfunction­­­­associated steatotic liver disease (MASLD) and arterial hypertension (AH).
Materials and methods. Examinations involved 102 patients, who were allocated into three groups: the main group included 40 patients with MASLD and AH comorbid course; the comparison group consisted of 42 patients with isolated MASLD course, and control group included 20 relatively healthy subjects. The mean patients’ age was 46.23±9.3 years. All patients underwent a collection of complaints, anamnesis, physical and general clinical examination, measurement of blood pressure (BP), daily BP monitoring, determination of endothelial dysfunction indicators (endothelial nitric oxide synthase (eNOS), uric acid (UA), fibrinogen, endothelium­­­­dependent vasodilation of the brachial artery (EDV BA).
Results. Significantly decreased levels of eNOS (p=0.001), EDV BA (p=0.001), and increased levels of UA (p <0.05) and fibrinogen (p <0.05) were revealed in the groups of patients with MASLD and AH combined course in comparison with the group of patients with isolated MASLD, as well as in comparison of these groups with the control group (p1 <0.01, p2 <0.01). Thus, the average eNOS levels in patients with comorbid pathology was 295.6±35.67 pg/ml, 356.7±28.34 pg/ml in the group of patients with isolated MASLD and 431.5±25.65 pg/ml in the control group. The average of EDV BA levels among examined patients were the following: 2.11±0.67% in patients with MASLD and AH, 2.15±0.48% in the group of isolated MASLD, and 3.07±0.56% in the control group. The following average UA level were defined: 406.4±25.6 µmol/l in patients with comorbid pathology, 369.3±27.8 µmol/l in the group of patients with MASLD, and (308, 9±15.7) µmol/l in the control group. The average level of fibrinogen in patients with the comorbid course of MASLD and AH was 4.4±1.4 g/l, 3.8±1.3 g/l in patients with isolated MASLD, and 2, 4±1.1 g/l in the control group. In addition, significantly decreased levels of eNOS (p=0.01), EDV BA (p=0.01), and increased levels of UA (p <0.01) were found in patients with MASLD against the background of AH stage II in comparison with patients with MASLD and AH stage I.
Conclusions. Analysis of the levels of indicators of endothelial functional state demonstrated correlation between endothelial dysfunction and MASLD development and progression of AH in patients with MASLD and AH comorbid course.
Clinical and instrumental characteristics of cardiogenic ischemic stroke caused by acute myocardial infarction
Authors: Muravska O. M. , Troyan O. I. , Muravskiy A. V. , Sydorenko O. F. , Marushchenko M. O. 
Published: July 2024

The aim of the study was to investigate the clinical, neurological, cardiac, hemodynamic and neuroimaging characteristics of cardiogenic ischemic stroke (IS) caused by myocardial infarction (MI).
Materials and methods. We examined 142 patients who suffered IS in the acute (up to 10 days) and postinfarction (up to 6 months) periods of MI. The control group consisted of 34 people who had no signs of cardiac and cerebrovascular pathology. Clinical‑neurological and cardiological examination; neuropsychological examination; magnetic resonance imaging (MRI) of the brain, ultrasound imaging of extra‑ and intracranial vessels — transcranial Doppler and transcranial duplex scanning, electrocardiography (ECG), transthoracic echocardiography were used.
Results. In the acute period of MI, HDS developed more often, and in the postinfarction period — CES. The most common cause of IS was anterior‑apical septal and anterolateral MI with Q‑wave. In CES, aneurysm and thrombosis of the LV, dilatation and thrombosis of the LA, aneurysm of the interventricular septum were more often detected in both periods of MI. Heart rhythm disturbances were detected: in HDS — AV block II—III degree; in CES — paroxysmal form of AF. According to MRI data, in HDS, the foci of ischemia were localized mainly in the deep cerebral hemispheres, cerebellum and brainstem; in CES — in the cortical‑subcortical regions of the left frontal lobe, and the formation of multiple «dumb» foci of ischemia and hemorrhagic transformation was characteristic. The occlusion of extra‑ and intracranial arteries on the side of cerebral infarction was caused by cardiogenic embolism due to MI. Hemodynamically insignificant stenoses of the main arteries of the head in GDI worsened blood flow in their blood supply pool in the acute period of MI.
Conclusions. It is recommended that all patients with IS caused by MI should undergo a detailed cardiac and neurological examination. The clinical, neurological, cardiac, hemodynamic and neuroimaging characteristics of cardiogenic IS caused by MI will allow to optimize therapy.
Assessment of clinical and biochemical parameters as indicators of ageing at wartime
Authors: Kolesnikova O. V. , Radchenko A. O. , Zaprovalna O. Y. , Emelyanova N. Y. 
Published: July 2024

Objective — to evaluate clinical and biochemical parameters and related differences in the rate of aging in patients with arterial hypertension (AH) during the year 2023.
Materials and methods. Examinations involved 39 patients with AH with a median age of 51.4 [46.9; 63.2] years, from them 27 were men (69.2%). Examinations were performed twice: at baseline and after the treatment and preventive activities. Depending on the time of the follow‑up visit, patients were divided into two groups, comparable by gender: group 1 with follow up visit conducted up to 27 weeks after first evaluation (n=19), group 2 with follow up visit conducted at more than 27 weeks (n=20). The assessment of phenotypic age (PA) and delta age (ΔPA) as markers of aging was conducted according to the DNAm PhenoAge calculation method (M. E. Levine, 2018).
Results. The significant changes have been revealed in the following parameters: waist circumference (WC) (p=0.008), absolute lymphocyte count (p=0.003), mean corpuscular hemoglobin concentration (p=0.032), red cell distribution width (RDW) (p=0.049), alkaline phosphatase (ALP) (p=0.0001), total cholesterol (TC) (p=0.019), triglycerides (TG) (p=0.010), very low‑density lipoprotein cholesterol (VLDL‑C) (p=0.038), amylase (p=0.038), uric acid (p=0.038), and total protein (p=0.008). Significant differences were established in group 1 in WC (p=0.042) and total protein (p=0.040), and in group 2 in lymphocyte count (p=0.010), RDW (p=0.016), ALP (p=0.001), TG (p=0.049), uric acid (p=0.018), and albumin (p=0.020). Patients with AH had lower results of prothrombin time (p=0.018), international normalized ratio (p=0.018), and higher prothrombin activation by Quick’s method (p=0.026). Levels of C‑reactive protein were lower in both overall patients with AH (p=0.004), and separately in groups 1 (p=0.044) and 2 (p=0.034). During the second follow‑up visit, the rate of aging increased in 51.6% of patients with AH. There was an association (p <0.05) between the increase in aging rates and the development of unfavorable anthropometric status, lipid profile, and the development of pro‑inflammatory state. There was also a direct correlation between thrombocrit and the acceleration of aging rates (p=0.025).
Conclusions. Screening for premature aging in patients with AH can be based on the assessment of aging rates according to M. Levine’s method (2018). This screening should be conducted more than once a year with account of the individual risk factors. During the wartime, patients with AH may require monitoring of anthropometric parameters and standard clinical‑biochemical indicators, especially lipid profile, renal tests (albumin, uric acid), glucose, and alkaline phosphatase (ALP), at least twice a year to prevent accelerated aging rates.
ANALISIS KUALITAS PELAYANAN DAN KETEPATAN WAKTU PENGIRIMAN TERHADAP LOYALITAS PELANGGAN DI EKSPEDISI JNE KOTA TANGERANG
Authors: Sahara Siti , Adelina Febi 
Published: July 2024

Penelitian ini dilakukan di PT. Jalur Nugraha Ekakurir (JNE) Kota Tangerang. Penelitian ini bertujuan untuk mengetahui pengaruh secara simultan antara kualitas pelayanan dan ketepatan waktu terhadap loyalitas pelanggan. Sampel yang digunakan dalam penelitian ini adalah pelanggan yang menggunakan jasa ekspedisi JNE. Teknik yang digunakan untuk pengambilan sampel adalah kuesioner dengan analisis kuantitatif. Penelitian ini dibantu dengan menggunakan software SPSS 64 For Windows untuk menguji simultan (uji F) dan parsial (uji T). Dapat disimpulkan bahwa kualitas pelayanan dan ketepatan waktu pengiriman berpengaruh signifikan terhadap loyalitas pelanggan JNEKata Kunci: Kualitas Pelayanan, Ketepatan Waktu, Loyalitas Pelanggan
PENGARUH PERCEIVED ORGANIZATION SUPPORT TERHADAP KOMITMEN DAN KINERJA KARYAWAN PT MNO: PERAN MEDIASI KEPUASAN KARYAWAN
Authors: Ingantaras Sembiring Gabriel Novriandi , Nugraha Andhyka Tyaz 
Published: July 2024

Penelitian ini bertujuan untuk mengkaji hubungan antara Perceived Organization Support (POS) dengan kinerja, komitmen dan bahkan kepuasan karyawan serta menyelidiki apakah kepuasan karyawan mampu memediasi hubungan antara Perceived Organization Support (POS) kepada kinerja dan komitmen karyawan. Data penelitian yang dikumpulkan sebanyak 169 responden. Metode penelitian menggunakan SEM dengan bantuan software Smart-PLS versi 3. Hasil Dari pengujian hipotesis di mana ditemukan bahwa POS memiliki dampak baik terhadap kinerja maupun komitmen yang dimiliki karyawan. Selain itu, penelitian ini menemukan bahwa kepuasan karyawan dapat memediasi hubungan antara POS dengan kinerja dan komitmen karyawan. Dalam konteks PT MNO, perusahaan berusaha memperbaiki dan meningkatkan rasa komitmen melalui dukungan serta evaluasi secara lebih lanjut terhadap dukungan yang mereka berikan. Tentunya, selain komitmen, PT MNO juga berusaha mempertahankan bahkan meningkatkan kinerja karyawannya demi menciptakan perusahaan yang unggul dan berkelanjutan.Kata Kunci: Perceived Organization Support, Kinerja Karyawan, Komitmen karyawan, Kepuasan Karyawan.
PENERAPAN METODE 8D BERBASIS 5 WHY DAN FAULT TREE ANALYSIS UNTUK MENGURANGI KECACATAN DAN KOMPLAIN PRODUK DI CV. X
Authors: Widodo Dian Setiya , Wulandari Anita , Wahyudi Pongky Lubas 
Published: July 2024

CV. X merupakan industri yang bergerak di bidang injection molding dan karton, juga melayani jasa pembuatan produk dari pelanggan. Permasalahan yang dihadapi oleh CV. X adalah adanya kasus komplain pelanggan yang berulang dari konsumen yang berbeda terkait kualitas produk karton membuat perusahaan perlu menangani serius dan lebih lanjut. Tujuan penelitian ini yaitu untuk mengurangi kecacatan produk yang berdampak pada komplain dari pelanggan. Berdasarkan kondisi tersebut perlu solusi yang ditawarkan yaitu Penerapan metode 8D yang terdiri dari 9 tahapan nantinya akan diintegrasikan dengan tools 5 Why dan Fault Tree Analysis (FTA) untuk mengidentifikasi akar permasalahan yang terjadi. Dari hasil pengolahan dan analisis data yang dilakukan dengan menerapkan metode 8D berbasis 5 why dan FTA mampu mengurangi total defect sehingga komplain pelanggan dapat teratasi. Kata Kunci: 8D, 5Why, FTA, Defect, Komplain
IDENTIFIKASI RISIKO MENGGUNAKAN METODE TURTLE DIAGRAM DAN FMEA PADA PROSES PRODUKSI KEMASAN KARTON BOX
Authors: Wahyudi Pongky Lubas , Jabir Ahmad , Falah Syaiful 
Published: July 2024

Risiko adalah suatu keadaan di mana terdapat kemungkinan kerugian. Dalam menghadapi persaingan global tentunya juga menghadapi risiko yang semakin meningkat, sehingga sangat penting untuk pencegahannya. Kontrol risiko yang dijalankan di perusahaan saat ini masih bersifat reaktif, tanpa panduan untuk mengidentifikasi dan mengatasi gangguan, sehingga tujuan dari penelitian ini adalah untuk mengidentifikasi risiko-risiko kritis dalam proses operasional di perusahaan tersebut. Metode Turtle Diagram dan FMEA digunakan untuk analisis dalam menyusun analisa risiko dari pengumpulan data, pengamatan dan wawancara yang dilakukan sebelumnya. Hasil dari penelitian ini menghasilkan dokumen inventarisasi risiko melalui analisis risiko, yang dapat digunakan untuk menangani masalah yang terjadi di perusahaan dan merekomendasikan tindakan mitigasi risiko serta menyajikan proses manajemen risiko yang dinamis untuk digunakan saat sekarang dan kedepannya.Kata Kunci: Manajemen Risiko, Turtle Diagram, FMEA
PENERAPAN METODE SPC (STATISTICAL PROCESS CONTROL) UNTUK MENGANALISIS OIL LOSSES PADA TANDAN KOSONG MINYAK KELAPA SAWIT DI PT. HARI SAWIT JAYA
Authors: Sofyan Diana Khairani 
Published: July 2024

Kelapa sawit merupakan komoditas perkebunan terbesar di Indonesia, intensitas cahaya dan persediaan air merupakan faktor utama pertumbuhan tanaman kelapa sawit. Kehilangan minyak kelapa sawit pada proses produksi merupakan hal yang wajar dalam proses pengolahan. Oil losses merupakan kehilangan jumlah minyak yang seharusnya diperoleh dari hasil suatu proses namun minyak tersebut tidak dapat diperoleh atau hilang. PT. Hari Sawit Jaya merupakan perusahaan industri yang mengolah kelapa sawit (TBS) menjadi minyak sawit mentah (CPO). Berdasarkan data yang diperoleh pada PT. Hari Sawit Jaya terdapat data kehilangan minyak distasiun kerja yaitu stasiun perebusan (sterilizer) pada tandan kosong dengan persentase kehilangan minyak adalah 1,72%. Hal ini menunjukkan bahwa kerugian minyak melebihi batas yang telah ditetapkan oleh perusahaan. Hasil yang diperoleh adalah pada tandan kosong terdapat data yang diluar batas control sehingga dilakukan perhitungan ulang untuk menghilangkan data yang berada pada luar batas control. Uji kecukupan data pada tandan kosong terdapat N>N', 23>20,85, maka data dinyatakan cukup. Peta kendali p membantu pengendalian kualitas produksi serta dapat memberikan informasi mengenai tingkat kerusakan yang terjadi pada perusahaan sehingga perusahaan harus melakukan perbaikan kualitasKata Kunci: Kelapa sawit, kehilangan minyak, Statistical Process Control (SPC)
PENERAPAN LEAN WAREHOUSING UNTUK MINIMASI PEMBOROSAN PADA WAREHOUSE FINISHED GOODS DIVISI INLINE PT. DUA KELINCI
Authors: Fauzy Reza Nur , Setiawan Eko 
Published: July 2024

Peningkatan kinerja harus dilakukan secara terus menerus pada semua lini proses produksi agar dapat meminimalisir pemborosan yang terjadi salah satunya dengan menerapkan lean warehouse. Penelitian ini dilakukan pada gudang PT. Dua Kelinci divisi inline yang bergerak di bidang penyedia makanan ringan. Tujuan dari penelitian ini yaitu mengetahui jenis pemborosan apa saja yang terdapat di gudang, mengidentifikasi dan menganalisis pemborosan yang memiliki nilai tertinggi, kemudian mengurangi pemborosan tersebut. Big picture mapping digunakan untuk memetakan secara visual dan menganalisis pemborosan yang terjadi pada aliran proses produksi di gudang. Untuk mengetahui pemborosan yang paling banyak terjadi digunakan kuesioner dan didapatkan pemborosan dengan nilai tertinggi yaitu pemborosan jenis movement. Selanjutnya diidentifikasi penyebab terjadinya movement tersebut dengan menggunakan fishbone diagram. Dengan menggunakan pendekatan 5S (Seiri, Seiton, Seiso, Seiketsu, Shitsuke), penelitian ini menyarankan pengurangan movement dengan pembuangan barang tidak diperlukan; pemberian garis area batas stasiun kerja; pembuatan jadwal periode pembersihan; pengetatan prosedur kerja; dan penataan ulang.Kata Kunci: Big Picture Mapping, Gudang Barang Jadi, Lean, Waste
Tribulation and Persecution as the Path of Christ and His Disciples in the Gospel of John: an Experience of Narrative Analysis
Authors: Викулов Андрей С. 
Published: July 2024

В данной статье анализируется содержание Евангелия от Иоанна в ракурсе отражения в нем темы скорбей и гонений на Христа и Его учеников. Автор акцентируется на том, чтобы,во-первых,определить природу и степень гонений; во-вторых,установить их причины; в-третьих, выяснить, каков был ответ Христа, когда Он столкнулся с гонениями, и как следует ученикам реагировать на них в подобных ситуациях. В статье утверждается, что скорби и преследования были реальны и вполне могли окончиться смертью для учеников Христовых. Последователи Спасителя первого века христианства были изгнаны из своей общины, вследствие чего теряли основу социальной жизни и сталкивались с полным лишением всех возможностей в области финансов, образования и общественной жизни.
This article analyzes the content of the Gospel of John in the course of reflecting in it the theme of tribulation and persecution of Christ and His disciples. Firstly, the author focuses on to determine the nature and degree of persecution; secondly, to establish their causes; thirdly, to find out what was the response of Christ when He faced persecution, and how the disciples should react to them in such situations. The article asserts that the tribulations and persecutions were real and it was quite possible that they could end in death for the disciples of Christ. The followers of the Savior of the first century of Christianity were expelled from their community, as a result of which they lost the basis of social life and faced complete deprivation of all opportunities in the field of finance, education and public life.
Perception of Hierarchical Church Institutions by the Kyiv Metropolis (On the Example of the Institute of Deaconesses)
Authors: Зотин Андрей 
Published: July 2024

В статье анализируется гипотеза Е. Е. Голубинского о существовании диаконисс в Русской Церкви. Рассматриваются предположения С. В. Троицкого и других исследователей о юрисдикционном статусе новосозданной Киевской митрополии церковной структуры Византийской Империи.
The article analyzes the hypothesis of E. E. Golubinsky on the existence of deaconesses in the Russian Church. The assumptions of S. V. Troitsky and other researchers on the jurisdictional status of the newly created Kyiv Metropolis of the church structure of the Byzantine Empire.
xperience of Codification of Church Legislative Acts of the Russian Orthodox Church in the Synodal Period
Authors: Пименов Георгий Иеромонах 
Published: July 2024

В данной статье рассматривается процесс систематизации и кодификации церковно-законодательных актов Русской Православной Церкви в Синодальный период: производится анализ истории этого процесса, его цели и результаты, а также оценивание актуальных для того периода канонических сборников. Также в статье указывается на основные принципы и методы кодификации церковного законодательства, а также его значение для правовой системы Русской Православной Церкви.
This article examines the process of systematization and codification of church legislative acts of the Russian Orthodox Church during the Synodal period: an analysis of the history of this process, its goals and results, as well as an assessment of canonical collections relevant for that period. The article also points out the basic principles and methods of codification of church legislation, as well as its significance for the legal system of the Russian Orthodox Church.