bluuebunny/crossref_metadata_2025_split huggingface dataset:
Popliteal cysts and subgastrocnemius bursitis are associated with knee symptoms and structural abnormalities in older adults: a cross-sectional study
Authors: Cao Yuelong , Jones Graeme , Han Weiyu , Antony Benny , Wang Xia , Cicuttini Flavia , Ding Changhai 
Published: March 2014

Abstract
Introduction
The role of popliteal cysts and subgastrocnemius bursitis in knee joint homeostasis is uncertain. The aim of this study is to describe cross-sectional associations between popliteal cysts, subgastrocnemius bursitis, knee symptoms and structural abnormalities in older adults.

Methods
A cross-sectional sample of 900 randomly-selected subjects (mean age 63 years, 48% female) were studied. Knee pain, stiffness and dysfunction were assessed by self-administered Western Ontario McMaster Osteoarthritis Index (WOMAC) questionnaire. Radiographic knee osteophyte and joint space narrowing (JSN) were recorded. Magnetic resonance imaging (MRI) was utilized to assess popliteal cysts, subgastrocnemius bursitis, cartilage defects and bone marrow lesions (BMLs).

Results
Popliteal cysts were present in 11.7% and subgastrocnemius bursitis in 12.7% of subjects. Subgastrocnemius bursitis was more common in those with popliteal cyst (36.2% versus 9.7%, P <0.01). In multivariable analyses, popliteal cysts were significantly associated with increased osteophytes in both medial and lateral tibiofemoral compartments while subgastrocnemius bursitis was associated with increased osteophytes and JSN in the medial tibiofemoral compartment. Both were significantly associated with cartilage defects in all compartments, and with BMLs in the medial tibiofemoral compartment. Furthermore, both popliteal cysts and subgastrocnemius bursitis were significantly associated with increased weight-bearing knee pain but these associations became non-significant after adjustment for cartilage defects and BMLs.

Conclusions
Popliteal cysts and subgastrocnemius bursitis are associated with increased symptoms as well as radiographic and MRI-detected joint structural abnormalities. Longitudinal data will help resolve if they are a consequence or a cause of knee joint abnormalities.
Impact of compliance with infection management guidelines on outcome in patients with severe sepsis: a prospective observational multi-center study
Authors: Bloos Frank , Thomas-Rüddel Daniel , Rüddel Hendrik , Engel Christoph , Schwarzkopf Daniel , Marshall John C , Harbarth Stephan , Simon Philipp , Riessen Reimer , Keh Didier , Dey Karin , Weiß Manfred , Toussaint Susanne , Schädler Dirk , Weyland Andreas , Ragaller Maximillian , Schwarzkopf Konrad , Eiche Jürgen , Kuhnle Gerhard , Hoyer Heike , Hartog Christiane , Kaisers Udo , Reinhart Konrad ,   for the MEDUSA Study Group
Published: March 2014

Abstract
Introduction
Current sepsis guidelines recommend antimicrobial treatment (AT) within one hour after onset of sepsis-related organ dysfunction (OD) and surgical source control within 12 hours. The objective of this study was to explore the association between initial infection management according to sepsis treatment recommendations and patient outcome.

Methods
In a prospective observational multi-center cohort study in 44 German ICUs, we studied 1,011 patients with severe sepsis or septic shock regarding times to AT, source control, and adequacy of AT. Primary outcome was 28-day mortality.

Results
Median time to AT was 2.1 (IQR 0.8 – 6.0) hours and 3 hours (-0.1 – 13.7) to surgical source control. Only 370 (36.6%) patients received AT within one hour after OD in compliance with recommendation. Among 422 patients receiving surgical or interventional source control, those who received source control later than 6 hours after onset of OD had a significantly higher 28-day mortality than patients with earlier source control (42.9% versus 26.7%, P <0.001). Time to AT was significantly longer in ICU and hospital non-survivors; no linear relationship was found between time to AT and 28-day mortality. Regardless of timing, 28-day mortality rate was lower in patients with adequate than non-adequate AT (30.3% versus 40.9%, P < 0.001).

Conclusions
A delay in source control beyond 6 hours may have a major impact on patient mortality. Adequate AT is associated with improved patient outcome but compliance with guideline recommendation requires improvement. There was only indirect evidence about the impact of timing of AT on sepsis mortality.
Kraken: ultrafast metagenomic sequence classification using exact alignments
Authors: Wood Derrick E , Salzberg Steven L 
Published: March 2014

AbstractKraken is an ultrafast and highly accurate program for assigning taxonomic labels to metagenomic DNA sequences. Previous programs designed for this task have been relatively slow and computationally expensive, forcing researchers to use faster abundance estimation programs, which only classify small subsets of metagenomic data. Using exact alignment of k-mers, Kraken achieves classification accuracy comparable to the fastest BLAST program. In its fastest mode, Kraken classifies 100 base pair reads at a rate of over 4.1 million reads per minute, 909 times faster than Megablast and 11 times faster than the abundance estimation program MetaPhlAn. Kraken is available at http://ccb.jhu.edu/software/kraken/.
Coal seismic surveying over near-surface basalts: Experience from Central Queensland, Australia
Authors: Zhou Binzhong , Hatherly Peter , Peters Troy , Sun Weijia 
Published: March 2014

Seismic reflection surveying in basalt-covered areas often fails to image underlying reflectors. To gain insights into the nature of the problem and obtain potential solutions, we have conducted experimental 2D seismic reflection and offset VSP surveys at two coal mines in the Bowen Basin of Australia. At the first mine, the basalt is relatively deep (114 m) and relatively thin (20 m). Conventional seismic acquisition and processing of a 2D seismic line provide poor results. However, upgoing reflections from layers below the basalt are clearly evident in the VSP survey and prestack depth migration is able to improve the continuity of the reflectors beneath the basalt. At the second mine, the 360 m wide basalt is at a depth of 40 m and has a thickness of about 40 m. It is fresh and unweathered and consists of multiple flows which are interlayered with unconsolidated sediments. Long-offset data acquisition combined with prestack depth migration was expected to produce satisfactory results but this is not the case. The associated VSP survey suggests that the problems at this mine are due to (1) the generation of complex downgoing and upgoing wave-fields within the basalt and (2) significant scattering of surface waves from outside the basalt at the margins of the basalt. Another problem is that the target coal seams are at about 300 m depth and the muting required to remove refraction events limited the effectiveness of the prestack depth migration. Reducing the strength of the surface waves through selection of an appropriate source and placement of shots at the base of the low-velocity zone (as had been the case at the first mine) will therefore improve the chances for a successful outcome. A Vibroseis survey subsequently undertaken at the second mine, which produced shot records with reduced surface waves, shows this to be the case.
Seeking clarity in the twilight zone
Authors: Vallance Aaron K. 
Published: March 2014

SummaryThis commentary offers further arguments relating to the ambiguities inherent in the new concept of the zone of parental control (ZPC) as defined by the revised Mental Health Act Code of Practice, but argues that a directive approach needs to be balanced with flexibility. The conflicting rights of child, parent and State are also discussed. Whereas medico-legal discourse tends to base itself on previous legislative frameworks, it is argued that an evidence-based approach may also be valuable in order to ascertain and incorporate young people's views on the matter.
Rates of violence in patients classified as high risk by
structured risk assessment instruments
Authors: Singh Jay P. , Fazel Seena , Gueorguieva Ralitza , Buchanan Alec 
Published: March 2014

BackgroundRates of violence in persons identified as high risk by structured risk
assessment instruments (SRAIs) are uncertain and frequently unreported by
validation studies.AimsTo analyse the variation in rates of violence in individuals identified
as high risk by SRAIs.MethodA systematic search of databases (1995–2011) was conducted for studies on
nine widely used assessment tools. Where violence rates in high-risk
groups were not published, these were requested from study authors. Rate
information was extracted, and binomial logistic regression was used to
study heterogeneity.ResultsInformation was collected on 13 045 participants in 57 samples from 47
independent studies. Annualised rates of violence in individuals
classified as high risk varied both across and within instruments. Rates
were elevated when population rates of violence were higher, when a
structured professional judgement instrument was used and when there was
a lower proportion of men in a study.ConclusionsAfter controlling for time at risk, the rate of violence in individuals
classified as high risk by SRAIs shows substantial variation. In the
absence of information on local base rates, assigning predetermined
probabilities to future violence risk on the basis of a structured risk
assessment is not supported by the current evidence base. This
underscores the need for caution when such risk estimates are used to
influence decisions related to individual liberty and public safety.
Intra- and interspecific challenges modulate cortisol but not androgen levels in a year-round territorial damselfish
Authors: Ros Albert F.H. , Vullioud Philippe , Bruintjes Rick , Vallat Armelle , Bshary Redouan 
Published: February 2014

Abstract
Interactions between individuals of different species are commonplace in animal communities. Some behaviors displayed during these interspecific social interactions may be very similar to those displayed during intraspecific social interactions. However, whether functional analogies between intra- and interspecific behaviors translate at the proximate level into an overlap in their underlying endocrine mechanisms remain largely unknown. Because steroids both mediate social behaviors and respond to them, we approached this question by comparing the behavioral and steroid response of free living dusky gregories (Stegastes nigricans [Lacepède, 1802]) to standardized territorial intrusions (sTI) of either conspecific or heterospecific food competitors. S. nigricans is a year-round territorial fish that “cultivates” the algae on which it feeds and is highly aggressive to both intra- and interspecific intruders. Behavioral differences between intra- and interspecific aggressive responses to sTI were marginal, and sTI tests caused an increase in cortisol levels that was positively related with the levels of aggression. In contrast, androgen levels did not increase in response to sTI, yet they showed a positive relationship with agonistic behavior. These results parallel a pattern that was first described for year-round territorial bird species. Furthermore they suggest that changes in endocrine-hormone levels during territoriality might be independent of the species that induces the territorial response.
The olfactory neuron AWC promotes avoidance to normally palatable food following chronic dietary restriction
Authors: Olofsson Birgitta 
Published: February 2014

AbstractChanges in metabolic state alter foraging behavior and food preference in animals. Here I show that normally attractive food becomes repulsive to C. elegans if animals are chronically under-nourished due to alimentary tract defects. This behavior plasticity is achieved in two ways: increased food leaving and induction of aversive behaviour towards food. A particularly strong food avoider is defective in the chitin synthase that makes the pharyngeal lining. Food avoidance induced by underfeeding is mediated by cGMP signaling in the olfactory neurons AWC and AWB, the gustatory neurons ASJ and ASK. Food avoidance is enhanced by increased population density and is reduced if the animals are unable to correctly interpret their nutritional state due to defects in the AMP kinase or TOR/S6kinase pathways. The TGF-β/DBL-1 suppresses food avoidance and the cellular basis for this is distinct from its role in aversive olfactory learning to harmful food. This study suggests that nutritional state feedback via nutrient sensors, population size, and olfactory neurons guide food preference in C. elegans.
An epidemiological study of rotator cuff pathology using The Health Improvement Network database
Authors: White J. J. E. , Titchener A. G. , Fakis A. , Tambe A. A. , Hubbard R. B. , Clark D. I. 
Published: March 2014

Little is known about the incidence of rotator cuff pathology or its demographic associations in the general population. We undertook a large epidemiological study of rotator cuff pathology in the United Kingdom using The Health Improvement Network (THIN) database. The incidence of rotator cuff pathology was 87 per 100 000 person-years. It was more common in women than in men (90 cases per 100 000 person-years in women and 83 per 100 000 person-years in men; p < 0.001). The highest incidence of 198 per 100 000 person-years was found in those aged between 55 and 59 years. The regional distribution of incidence demonstrated an even spread across 13 UK health authorities except Wales, where the incidence was significantly higher (122 per 100 000 person-years; p < 0.001). The lowest socioeconomic group had the highest incidence (98 per 100 000 person-years). The incidence has risen fourfold since 1987 and as of 2006 shows no signs of plateauing. This study represents the largest general population study of rotator cuff pathology reported to date. The results obtained provide an enhanced appreciation of the epidemiology of rotator cuff pathology and may help to direct future upper limb orthopaedic services. Cite this article: Bone Joint J 2014;96-B:350–3.
Delayed debridement of severe open fractures is associated with a higher rate of deep infection
Authors: Hull P. D. , Johnson S. C. , Stephen D. J. G. , Kreder H. J. , Jenkinson R. J. 
Published: March 2014

This study explores the relationship between delay to surgical debridement and deep infection in a series of 364 consecutive patients with 459 open fractures treated at an academic level one trauma hospital in North America. The mean delay to debridement for all fractures was 10.6 hours (0.6 to 111.5). There were 46 deep infections (10%). There were no infections among the 55 Gustilo-Anderson grade I open fractures. Among the grade II and III injuries, a statistically significant increase in the rate of deep infection was found for each hour of delay (OR = 1.033: 95% CI 1.01 to 1.057). This relationship shows a linear increase of 3% per hour of delay. No distinct time cut-off points were identified. Deep infection was also associated with tibial fractures (OR = 2.44: 95% CI 1.26 to 4.73), a higher Gustilo-Anderson grade (OR = 1.99: 95% CI 1.004 to 3.954), and contamination of the fracture (OR = 3.12: 95% CI 1.36 to 7.36). These individual effects are additive, which suggests that delayed debridement will have a clinically significant detrimental effect on more severe open fractures. Delayed treatment appeared safe for grade 1 open fractures. However, when the negative prognostic factors of tibial site, high grade of fracture and/or contamination are present we recommend more urgent operative debridement. Cite this article: Bone Joint J 2014;96-B:379–84.
The use of the transverse acetabular ligament in total hip replacement
Authors: Fujita K. , Kabata T. , Maeda T. , Kajino Y. , Iwai S. , Kuroda K. , Hasegawa K. , Tsuchiya H. 
Published: March 2014

It has recently been reported that the transverse acetabular ligament (TAL) is helpful in determining the position of the acetabular component in total hip replacement (THR). In this study we used a computer-assisted navigation system to determine whether the TAL is useful as a landmark in THR. The study was carried out in 121 consecutive patients undergoing primary THR (134 hips), including 67 dysplastic hips (50%). There were 26 men (29 hips) and 95 women (105 hips) with a mean age of 60.2 years (17 to 82) at the time of operation. After identification of the TAL, its anteversion was measured intra-operatively by aligning the inferomedial rim of the trial acetabular component with the TAL using computer-assisted navigation. The TAL was identified in 112 hips (83.6%). Intra-observer reproducibility in the measurement of anteversion of the TAL was high, but inter-observer reproducibility was moderate.Each surgeon was able to align the trial component according to the target value of the angle of anteversion of the TAL, but it was clear that methods may differ among surgeons. Of the measurements of the angle of anteversion of the TAL, 5.4% (6 of 112 hips) were outliers from the safe zone.In summary, we found that the TAL is useful as a landmark when implanting the acetabular component within the safe zone in almost all hips, and to prevent it being implanted in retroversion in all hips, including dysplastic hips. However, as anteversion of the TAL may be excessive in a few hips, it is advisable to pay attention to individual variations, particularly in those with severe posterior pelvic tilt.Cite this article: Bone Joint J 2014;96-B:306–11.
Decision making regarding spinal osteotomy and total hip replacement for ankylosing spondylitis
Authors: Zheng G. Q. , Zhang Y. G. , Chen J. Y. , Wang Y. 
Published: March 2014

Few studies have examined the order in which a spinal osteotomy and total hip replacement (THR) are to be performed for patients with ankylosing spondylitis. We have retrospectively reviewed 28 consecutive patients with ankylosing spondylitis who underwent both a spinal osteotomy and a THR from September 2004 to November 2012. In the cohort 22 patients had a spinal osteotomy before a THR (group 1), and six patients had a THR before a spinal osteotomy (group 2). The mean duration of follow-up was 3.5 years (2 to 9). The spinal sagittal Cobb angle of the vertebral osteotomy segment was corrected from a pre-operative kyphosis angle of 32.4 (SD 15.5°) to a post-operative lordosis 29.6 (SD 11.2°) (p < 0.001). Significant improvements in pain, function and range of movement were observed following THR. In group 2, two of six patients had an early anterior dislocation. The spinal osteotomy was performed two weeks after the THR. At follow-up, no hip has required revision in either group. Although this non-comparative study only involved a small number of patients, given our experience, we believe a spinal osteotomy should be performed prior to a THR, unless the deformity is so severe that the procedure cannot be performed.Cite this article: Bone Joint J 2014;96-B:360–5.
A preliminary study of manipulation under anaesthesia for secondary frozen shoulder following breast cancer treatment
Authors: Leonidou A , Woods DA 
Published: February 2014

Introduction The aim of this paper is to present the results of manipulation under anaesthesia (MUA) and injection of local anaesthetic and corticosteroid followed by a physiotherapy regime for secondary frozen shoulder after breast cancer treatment (surgery, radiotherapy), and to compare them with a control group. Methods Patients referred to the senior author for secondary frozen shoulder following breast cancer treatment over a ten-year period were investigated. Recorded data included age, treatment for breast cancer, length of symptoms, Oxford shoulder score (OSS) and range of motion before and after shoulder MUA. These data were compared with a control group of patients with frozen shoulder. Results A total of 263 patients were referred with 281 frozen shoulders. Of these, 7 patients (7 shoulders) had undergone previous breast cancer treatment and the remaining 256 patients (274 shoulders) formed the control group. None of the patients were diabetic. The mean preoperative OSS was 31 for the study group and 27 for the control group, improving to 43 for both groups following MUA. Forty-two per cent of the study group and fifteen per cent of the control group had a second MUA subsequently. At the long-term follow-up appointment, 71% of the study group patients were satisfied with their result. Conclusions The results of this preliminary study suggest that MUA, corticosteroid injection and subsequent physiotherapy have achieved good final results in a series of patients with frozen shoulder secondary to breast cancer treatment. Members of the multidisciplinary team looking after breast cancer patients should be aware of this management option and, on manifestation of this pathology, should refer the patient to an orthopaedic surgeon.
Predicting supervisor capacities to foster higher forms of learning through undergraduate medical student research
Authors: MacDougall Margaret 
Published: March 2014

The credibility of short-term undergraduate research as a paradigm for effective learning within Medicine has been recognized. With a view to strengthening this paradigm and enhancing research-teaching linkages, this study explores whether particular types of research supervisor are pre-disposed to providing supportive learning environments. Correspondingly, a novel solution is offered to addressing clinical governance concerns about failings in preparing students for a supercomplex world. While recommendations for addressing these concerns have previously focused on curriculum delivery and assessment, this study affords a fresh perspective through consideration of research supervisor attributes, behaviours and experiences. Using statistical analyses of response data from a large cohort of experienced research supervisors who completed an online survey, evidence is found to suggest that staff involvement in personal research ought to enhance student learning through research. In turn, the supervisor factors which are most supportive of this effect may vary according to how we measure higher forms of learning. Supervisors are advised to design successive follow-on research projects to facilitate cross-disciplinary research. In preparing medical graduates for survival in a super-complex world, more needs to be done, however, to investigate why supervisors who see their students more regularly are more likely to provide cross-disciplinary research opportunities. By contrast, potential to engage in risk-taking behaviours and maintain or progress to an advanced stage of learning may originate more precisely with the student.
A novel method for calibration and monitoring of time synchronization of TOF-PET scanners by means of cosmic rays
Authors: Silarski Michał , Czerwiński Eryk , Bednarski Tomasz , Moskal Paweł , Białas Piotr , Kapłon Łukasz , Kochanowski Andrzej , Korcyl Grzegorz , Kowal Jakub , Kowalski Paweł , Kozik Tomasz , Krzemień Wojciech , Molenda Marcin , Niedźwiecki Szymon , Pałka Marek , Pawlik Monika , Raczyński Lech , Rudy Zbigniew , Salabura Piotr , Sharma Neha Gupta , Słomski Artur , Smyrski Jerzy , Strzelecki Adam , Wiślicki Wojciech , Zieliński Marcin , Zoń Natalia 
Published: March 2014

Abstract
All of the present methods for calibration and monitoring of time-of-flight positron emission tomography (TOF-PET) scanner detectors utilize radioactive isotopes, such as 22Na or 68Ge, which are placed or rotate inside the scanner. In this article, we describe a novel method based on the cosmic rays application to the PET calibration and monitoring methods. The concept allows to overcome many of the drawbacks of the present methods and it is well suited for newly developed TOF-PET scanners with a large longitudinal field of view. The method enables also the monitoring of the quality of the scintillator materials and in general allows for the continuous quality assurance of the PET detector performance.