bluuebunny/crossref_metadata_2025_split huggingface dataset:
Anti‐hypertensive effect and potential mechanism of gastrodia‐uncaria granules based on network pharmacology and experimental validation
Authors: Liu Chu‐Hao , Xue Qi‐Qi , Zhang Yi‐Qing , Zhang Dong‐Yan , Li Yan 
Published: July 2024

AbstractHypertension has become a major contributor to the morbidity and mortality of cardiovascular diseases worldwide. Despite the evidence of the anti‐hypertensive effect of gastrodia‐uncaria granules (GUG) in hypertensive patients, little is known about its potential therapeutic targets as well as the underlying mechanism. GUG components were sourced from TCMSP and HERB, with bioactive ingredients screened. Hypertension‐related targets were gathered from DisGeNET, OMIM, GeneCards, CTD, and GEO. The STRING database constructed a protein–protein interaction network, visualized by Cytoscape 3.7.1. Core targets were analyzed via GO and KEGG using R package ClusterProfiler. Molecular docking with AutodockVina 1.2.2 revealed favorable binding affinities. In vivo studies on hypertensive mice and rats validated network pharmacology findings. GUG yielded 228 active ingredients and 1190 targets, intersecting with 373 hypertension‐related genes. PPI network analysis identified five core genes: AKT1, TNF‐α, GAPDH, IL‐6, and ALB. Top enriched GO terms and KEGG pathways associated with the anti‐hypertensive properties of GUG were documented. Molecular docking indicated stable binding of core components to targets. In vivo study showed that GUG could improve vascular relaxation, alleviate vascular remodeling, and lower blood pressure in hypertensive animal models possibly through inhibiting inflammatory factors such as AKT1, mTOR, and CCND1. Integrated network pharmacology and in vivo experiment showed that GUG may exert anti‐hypertensive effects by inhibiting inflammation response, which provides some clues for understanding the effect and mechanisms of GUG in the treatment of hypertension.
Using SWATH‐MS to identify new molecular biomarkers in gingival crevicular fluid for detecting periodontitis and its response to treatment
Authors: Blanco‐Pintos T. , Regueira‐Iglesias A. , Relvas M. , Alonso‐Sampedro M. , Chantada‐Vázquez M. P. , Balsa‐Castro C. , Tomás I. 
Published: July 2024

AbstractAimTo identify new biomarkers to detect untreated and treated periodontitis in gingival crevicular fluid (GCF) using sequential window acquisition of all theoretical mass spectra (SWATH‐MS).Materials and MethodsGCF samples were collected from 44 periodontally healthy subjects and 40 with periodontitis (Stages III–IV). In the latter, 25 improved clinically 2 months after treatment. Samples were analysed using SWATH‐MS, and proteins were identified by the UniProt human‐specific database. The diagnostic capability of the proteins was determined with generalized additive models to distinguish the three clinical conditions.ResultsIn the untreated periodontitis vs. periodontal health modelling, five proteins showed excellent or good bias‐corrected (bc)‐sensitivity/bc‐specificity values of >80%. These were GAPDH, ZG16B, carbonic anhydrase 1, plasma protease inhibitor C1 and haemoglobin subunit beta. GAPDH with MMP‐9, MMP‐8, zinc‐α‐2‐glycoprotein and neutrophil gelatinase‐associated lipocalin and ZG16B with cornulin provided increased bc‐sensitivity/bc‐specificity of >95%. For distinguishing treated periodontitis vs. periodontal health, most of these proteins and their combinations revealed a predictive ability similar to previous modelling. No model obtained relevant results to differentiate between periodontitis conditions.ConclusionsNew single and dual GCF protein biomarkers showed outstanding results in discriminating untreated and treated periodontitis from periodontal health. Periodontitis conditions were indistinguishable. Future research must validate these findings.
Advancing justice in flood risk management: Leveling political capabilities
Authors: Brackel Lieke , Pesch Udo , Doorn Neelke 
Published: July 2024

AbstractLand use change, managed retreat, and relocation programs are examples of exposure reduction measures in flood risk management (FRM). Exposure reduction measures are especially prone to conflict at the local level due to competing interests, values, and attachments. In this paper, we build upon the capability approach to justice and specifically the concept of political capabilities to advance justice in exposure reduction measures in FRM. A capabilities‐based approach to justice helps to recognize the multiplicity of valuable ways of life and addresses a wide range of inequalities including concerns related to recognition justice. The innovation of our capabilities‐based approach to justice is that we include both actors who have too little political influence as well as those who have too much and can thus excessively steer FRM in their advantage. A political capabilities analysis is different than a focus on principles or rights because it draws attention to realized political influence and includes the informal stages of FRM politics such as lobbying. The political capabilities concept also shifts the focus from vulnerability to human agency, thereby addressing concerns in the FRM literature about the loss of self‐determination and misrecognition. The paper concludes with a critical discussion of the opportunities and limitations of using the political capabilities concept in FRM.
Machine‐learning‐based demand forecasting against food waste: Life cycle environmental impacts and benefits of a bakery case study
Authors: Hübner Nicolas , Caspers Justus , Coroamă Vlad Constantin , Finkbeiner Matthias 
Published: July 2024

AbstractRapid advancements in artificial intelligence (AI) are driving transformative changes in many areas, with significant environmental implications. Yet, environmental assessments for specific applications are scarce. This study presents an in‐depth life cycle assessment of “Foodforecast,” a machine learning (ML) cloud service designed to reduce food waste in bakeries by optimizing sales forecasting. It covers four impact categories: global warming, abiotic resource depletion, cumulative energy demand, and freshwater eutrophication. The assessment includes both the direct environmental impacts of the ML model and the underlying system hardware, as well as the indirect benefits of avoided bakery returns compared to traditional ordering methods, using real‐world case study data. In 2022, “Foodforecast” led to an average 30% reduction in bakery returns, primarily bread and rolls, according to sales reports. The associated environmental benefits significantly outweighed the system's direct impacts by one to three orders of magnitude across impact categories and return utilization scenarios. The study identifies support activities such as service maintenance during deployment as major direct impact factors, surpassing those from cloud compute for ML operations. Data processing and inference dominate the latter, while the much‐discussed ML training plays a minor role. The environmental consequences of AI are complex and dual sided. This case study demonstrates that AI might provide environmental benefits in certain contexts, yet results are constrained by methodological challenges and data uncertainties. There remains a need for further holistic LCAs across different ML applications to inform decision‐making processes and ultimately guide the responsible use of AI.
Genomic variation of 363 diverse tea accessions unveils the genetic diversity, domestication, and structural variations associated with tea adaptation
Authors: Tong Wei , Wang Yanli , Li Fangdong , Zhai Fei , Su Jingjing , Wu Didi , Yi Lianghui , Gao Qijuan , Wu Qiong , Xia Enhua 
Published: July 2024

ABSTRACTDomestication has shaped the population structure and agronomic traits of tea plants, yet the complexity of tea population structure and genetic variation that determines these traits remains unclear. We here investigated the resequencing data of 363 diverse tea accessions collected extensively from almost all tea distributions and found that the population structure of tea plants was divided into eight subgroups, which were basically consistent with their geographical distributions. The genetic diversity of tea plants in China decreased from southwest to east as latitude increased. Results also indicated that Camellia sinensis var. assamica (CSA) illustrated divergent selection signatures with Camellia sinensis var. sinensis (CSS). The domesticated genes of CSA were mainly involved in leaf development, flavonoid and alkaloid biosynthesis, while the domesticated genes in CSS mainly participated in amino acid metabolism, aroma compounds biosynthesis, and cold stress. Comparative population genomics further identified ~730 Mb novel sequences, generating 6,058 full‐length protein‐encoding genes, significantly expanding the gene pool of tea plants. We also discovered 217,376 large‐scale structural variations and 56,583 presence and absence variations (PAVs) across diverse tea accessions, some of which were associated with tea quality and stress resistance. Functional experiments demonstrated that two PAV genes (CSS0049975 and CSS0006599) were likely to drive trait diversification in cold tolerance between CSA and CSS tea plants. The overall findings not only revealed the genetic diversity and domestication of tea plants, but also underscored the vital role of structural variations in the diversification of tea plant traits.
Feeling the heat: Extreme temperatures and housing prices in China
Authors: Kang Yankun , Niu Dongxiao , Song Jie , Sun Weizeng 
Published: July 2024

AbstractClimate change‐driven extreme heat events pose a major threat to urban expansion globally. This study evaluates the relationship between extreme heat and housing prices utilizing panel data from Chinese cities between 2009 and 2019. Our findings indicate a significant negative correlation between housing prices and extreme temperatures. Specifically, we observe a 0.1% reduction in housing prices for each additional day per year with temperatures surpassing 35°C. This research evaluates two primary mechanisms underpinning this finding. Firstly, our analysis demonstrates a decline in labor inflows to cities experiencing extreme heat, with a particularly significant effect on the influx of high‐skilled workers. In addition, existing residents in these hotter urban environments exhibit reduced home‐buying intentions and reduced proclivity for long‐term residency, coupled with higher living costs. Secondly, our findings indicate that extreme heat acts as a deterrent to firm entry, thereby further suppressing housing demand. This study contributes valuable empirical insights into the capitalization of climate risk in housing markets, with a specific emphasis on the effect of extreme heat. Moreover, it highlights the urgent necessity for the development and implementation of sustainable adaptation strategies to reduce the negative effects of evolving climatic conditions.
Influence of restricted mastication on swallowing function
Authors: Hayashi Hiroki , Kusunoki Takayuki , Komiyama Osamu , Hamada Yoshihiro , Kawamoto Akiyo , Takahashi Kazuya , Shimada Akiko 
Published: July 2024

AbstractBackgroundOral food processing is an important part of daily food intake. A major part of this process is mastication, which prepares a bolus of food for swallowing by mechanically crushing and grinding ingested food between the teeth using rhythmic movements. Masticatory dysfunction is common in the elderly and in some neurological disorders and can have serious negative health consequences.ObjectiveThis study investigated the effect of restricted mastication, achieved by experimentally reducing the duration of mastication, on masticatory patterns and subsequent swallowing function.MethodsThirty healthy men (25 ± 3 years old) were instructed to chew gum jelly with a free mastication duration (G100), a half and a quarter duration of G100. Masseter and digastric electromyographic (EMG) activity was recorded to assess mastication and swallowing activity, respectively. In addition, the acceleration of the thyroid cartilage ridge was measured with an accelerometer. The root mean square (RMS) of muscle EMG activity in the masseter and digastric muscles, the number of masseter EMG bursts, time to peak and total duration of each masseter EMG burst, swallowing duration and laryngeal elevation latency were analysed.ResultsRestricting masticatory duration reduced the number of mastication cycles (p < .001), prolonged the time to peak (p < .001) and total duration of masseter EMG bursts (p < .001) and resulted in an overall increased RMS score of masseter muscle activity (p = .017). Furthermore, restricted masticatory duration led to a decrease in both swallowing duration (p = .001) and laryngeal elevation latency (p = .012), with a significant increase in the RMS score of digastric muscle activity (p < .001).ConclusionsUnder the experimental conditions of restricted mastication, several adaptation features were observed, including changes in masticatory cycle characteristics and swallowing duration. Thus, although the overall masticatory efficiency was reduced, these adaptations allowed healthy individuals to still swallow safely.
It's not what you say it's what you do: School diversity ideologies and adolescent mental health and academic engagement
Authors: Leer Jane , Gaither Sarah E. , Gassman‐Pines Anna 
Published: July 2024

AbstractThis study examined the relation between schools' color‐evasive versus multicultural diversity ideologies, school characteristics, and adolescent development. Across two datasets linking individual‐level survey data (N = 1692) and administrative records (N = 300,063; Mage = 12.4, 52% female, 48% male), schools' stated support for diversity (via a pro‐diversity mission statement) was related to adolescent mental health and academic achievement, but in nuanced ways depending on individual racial/ethnic backgrounds, the racial/ethnic diversity of the student body and teachers, and the extent of racial disparities in discipline and gifted education. Findings suggest that communicating support for diversity without redressing systemic inequities in school discipline and academic tracking will not reduce racism‐related achievement gaps and may instead exacerbate mental health disparities.
Comparing fungicides and biologicals for grey mould control in semi‐hydroponic strawberry cultivation
Authors: Beger Giovana , Maia Juliana Nicolau , Linhares Juliana Campanholo , Peres Natalia Aparecida , Nesi Cristiano Nunes , May De Mio Louise Larissa , Duarte Henrique da Silva Silveira 
Published: July 2024

AbstractBiologicals and fungicides were evaluated for the control of grey mould in detached fruit in semi‐hydroponic strawberry cultivation. Bacillus subtilis (Serenade, Bio‐Baci, Bio‐Imune), B. amyloliquefaciens (No‐Nema), B. pumilus, B. velezensis (Bombardeiro, BTP 11–19 and BTP 135–19) were compared to the fungicide fluazinam in detached fruit assays. After treatment, fruits were inoculated with 30 μL of a 105 spores mL−1 suspension and incubated in a growth chamber. The relative risk for symptom expression in the treatments in relation to the control was estimated by survival analysis. In the field experiment, Serenade, No‐Nema, Bio‐Imune, Bombardeiro and BTP 11–19, the fungus Clonostachys rosea, procymidone, boscalid, fluazinam, pyrimethanil and cyprodinil + fludioxonil were tested. Biological products were sprayed every 7 days and fungicides at intervals of 14 days. Disease incidence (field and postharvest) and yield were evaluated. In the detached fruit assay, the fungicide fluazinam, followed by the biological products No‐Nema and Bio‐Imune, reduced the relative risk for symptom expression. In the field, cyprodinil + fludioxonil was the most efficacious at harvest. However, no differences in yield were observed. In postharvest, all fungicides in addition to C. rosea, No‐Nema and Bombardeiro reduced the incidence compared to the control during the main production peak (second), and cyprodinil + fludioxonil mixture was the most effective during the season. However, some biological products can be incorporated into an integrated management to reduce postharvest losses.
Involving parents and family environment for enhancing the mathematics education of children with Down syndrome
Authors: Gil‐Clemente Elena , Gasca Ana Millán , Badías Rebeca Paricio 
Published: July 2024

AbstractA research project involving 16 children with Down syndrome aged 4–14 approaching mathematics at home was developed during the COVID‐19‐lockdown in Spain. In the research project a series of 14 short mathematical challenges were designed and delivered in a WhatsApp group used as a communication and documentation tool with the participating families. Videos recorded by them were subsequently analyzed with the purpose of describing and analyzing: (a) the experience children live in contact with informal situations underlying the concepts of number and shape and (b) the engagement of families. The choice of these informal situations is based upon recent research that shows the need to consider the wide range of occasional experiences with mathematical ideas children have in their family prior to schooling. In order to design productive mathematical activities we drew on our past research for the choosing of crucial mathematical issues (whole numbers, plane geometry, and solids). We discuss the evolution in parents from practical help to deep engagement, and the fact that notwithstanding diversity in family contexts, engagement and an especially joyful approach to mathematics emerged. The use of videos opens up a path to the possibility to online learning for children with Down syndrome.
Disparities in being able to donate human milk impacts upon maternal wellbeing: Lessons for scaling up milk bank service provision
Authors: Brown Amy , Griffiths Catrin , Jones Sara , Weaver Gillian , Shenker Natalie 
Published: July 2024

AbstractReceiving donor human milk for a baby can have a protective effect upon parental wellbeing. A growing body of research also finds that being able to donate milk to a milk bank, particularly after infant loss, can also boost maternal wellbeing through feelings of altruism and purpose. However, most studies are qualitative, with small sample sizes outside the United Kingdom, and often do not include the experiences of those who have been unable to donate. Our aim was therefore to examine the impact of being able to donate milk, as well as the impact of not being able to do so, using a survey containing open and closed questions in a large UK sample. Overall, 1149 women completed the survey, 417 (36.3%) who donated their milk and 732 (63.7%) who did not. Most women who donated found it had a positive impact upon their wellbeing, feeling proud, useful and that they had achieved something important. Conversely, those unable to donate often felt rejected, frustrated, and excluded, especially if they received no response or felt that restrictions were unfair. Thematic analysis found that being able to donate could help women heal from experiences such as birth trauma, difficult breastfeeding experiences, neonatal unit stays, and infant loss; however, being unable to donate could exacerbate negative emotions arising from similar experiences. A minority of women who donated experienced raised anxiety over following guidelines. These findings further extend the impacts of milk banking services beyond infant health and development and support expanded service delivery.
Adherence to the Mediterranean diet during pregnancy and behavioural problems at 4 years of age
Authors: Cendra‐Duarte Esther , Canals Josefa , Iglesias‐Vázquez Lucía , Jardí Cristina , Martín‐Luján Francisco , Arija Victoria 
Published: July 2024

AbstractThere is an increasing prevalence of psychological issues in childhood. Lifestyle factors during pregnancy, including maternal nutrition, have been linked to children's behavioural development. This study aims to assess the impact of adherence to the Mediterranean diet during pregnancy on the behavioural problems of children at the age of 4. A total of 231 mother‐child pairs were assessed. Maternal adherence to the Mediterranean diet during pregnancy was estimated using a relative Mediterranean Diet Score (rMED). Behavioural outcomes were evaluated through the Child Behaviour Checklist 1½−−5, Teacher's Report Form 1½−5, and Behaviour Rating Inventory of Executive Function—Preschool Version questionnaires. The results indicated that a higher rMED score during pregnancy was associated with a reduced probability of obtaining a clinical score for total problems (OR = 0.42; 95% IC from 0.21 to 0.85), including externalising (OR = 0.29; 95% IC from 0.14 to 0.62), attention problems (OR = 0.32; 95%IC from 0.15 to 0.70), attention‐deficit/hyperactivity problems (OR = 0.36; 95% IC from 0.15 to 0.87), oppositional defiant problems (OR = 0.06; 95% IC from 0.06 to 0.75), and depressive problems (OR = 0.38; 95% IC from 0.15 to 0.96). This study highlights the importance of maternal diet, especially Mediterranean diet, during gestation for proper child development.
The functional lumen imaging probe contractile response pattern is the best predictor of botulinum toxin response in esophagogastric junction outflow obstruction
Authors: Biermann Maya , Obineme Chuma , Godiers Marie , Kundu Suprateek , Jain Anand S. 
Published: July 2024

AbstractBackgroundEsophagogastric junction outflow obstruction (EGJOO) is a heterogenous disorder in which the correct management strategy is unclear. We assessed whether functional lumen imaging probe (FLIP) topography data could select EGJOO, which would benefit from lower esophageal sphincter Botulinum toxin (Botox) injection.MethodsThis was a single‐center prospective study of adult patients meeting Chicago Classification (CC) v3.0 criteria for EGJOO. We assessed differences in pretreatment physiologic measurements on high‐resolution manometry (HRM) and FLIP and other relevant clinical variables in predicting Botox response (>50% in BEDQ at 2 months).Key ResultsSixty‐nine patients were included (ages 33–90, 73.9% female). Of these, 42 (61%) were Botox responders. Majority of physiologic measures on HRM and FLIP and esophageal emptying were not different based on Botox response. However, a spastic‐reactive (SR) FLIP contractile response (CR) pattern predicted a Botox response with OR 25.6 (CI 2.9–229.6) when compared to antegrade FLIP CR; and OR for impaired‐disordered/absent CR was 22.5 (CI 2.5–206.7). Logistic regression model using backward elimination (p value = 0.0001, AUC 0.79) showed that a SRCR or IDCR/absent response and the upright IRP predicted Botox response. Response rates in tiered diagnostic groups were: (i) CCv3.0 EGJOO (60.9%), (ii) CCv4.0 EGJOO (73.1%), (iii) CCv4.0 + FLIP REO (80%), (iv) CCv4.0, FLIP REO, and abnormal FLIP CR (84.2%), and (v) CCv4.0, FLIP REO, and SR FLIP CR (90%).Conclusions and InferencesFLIP helps identify patients with EGJOO who are likely to response to LES Botox therapy. An abnormal FLIP contractile response pattern is the single‐most important predictor of a Botox response.