bluuebunny/crossref_metadata_2025_split huggingface dataset:
PENGEMBANGAN MEDIA PEMBELAJARAN INTERAKKTIF ARTICULATE STORYLINE 3 PADA MATERI PECAHAN KELAS V
Authors: Maulita Yuliana Widi , Saputra Erwin Rahayu 
Published: July 2024

Media pembelajaran yang tidak bervariasi akan menyebabkan menurunnya minat peserta didik dalam belajar. Oleh karena itu dibutuhkan inovasi atau pengembangan media pembelajaran, khususnya media pembelajaran interaktif agar peserta didik turut berpartisipasi aktif dalam pembelajaran. Berdasarkan hal tersebut, penelitian ini bertujuan untuk menghasilkan media pembelajaran interakftif Articulate Storyline 3 pada materi pecahan kelas V sekolah dasar. Jenis penelitian ini adalah penelitian pengembangan. Penelitian ini menggunakan model penelitian yaitu model ADDIE. Teknik pengumpulan data menggunakan wawancara dan angket. Sampel penelitian adalah 25 peserta didik kelas 5 SDN 2 Tuguraja. Teknis analisis data yang digunakan dalam penelitian ini adalah reduksi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Berdasarkan hasil penelitian, didapat bahwa media pembelajaran interaktif Articulate Storyline 3 dinyatakan layak untuk digunakan pada proses pembelajaran dengan hasil validasi oleh ahli materi yaitu 92,% dan hasil validasi oleh ahli media yaitu 96,9%. Media pembelajaran Articulate Storyline 3 dapat dijadikan pertimbangan oleh para guru dalam memvariasikan media pembelajaranKata Kunci:Articulate Storyline 3, Media Pembelajaran Interaktif, Pecahan
The Development of Fushah Arabic in Indonesia
Authors: Mustofa Syaiful , Kamilaini Azka , Dahlan Ahmad Zaini , Latifah Dayyinati Erli 
Published: July 2024

Penelitian ini bertujuan untuk mengetahui bagaimana gambaran bahasa Arab Fusha dan untuk mengetahui pembelajaranya di Indonesia. Pendekatan penelitian ini adalah penelitian kualitatif dengan metode deskriptif. Objek penelitian adalah Pesantren di Indonesia dengan sampel pesantren Darul Lughoh. Pemerolehan data melalui wawancara dan dokumen. Hasil penelitian ini adalah pembelajaran bahasa Arab Fushah di Indonesia terbadi menjadi dua bagian yaitu periode klasik dan periode modern. Periode klasik dengan membaca kitab di depan santri secara bersama-sama (bandongan), secara individu (sorogan), dan menghafal kosa kata. Adapun periode modern dengan cara menggunakan media sosial berbasis teknologi, youtube, game, debat, diskusi, kegiatan siswa, dan kemah berbahasa (language came)
The Divergence of the Influence of Ulama and Dayah in the Dynamics of Electoral Politics in East Aceh Regency
Authors: Rahma Alya , Rizwan M , Muzaffarsyah Teuku , Faisal Naidi , Sarifa Sa 
Published: July 2024

This research discusses the dlvergence of influence of ulama and dayah in electoral politics in East Aceh Regency. Use of electoral political theory (elections), using qualitative research methods. Findings from the results of research in the fileld regarding "Divergence of influence of ulama and dayah in the electoral political constellation in East Aceh Regelcy", can be concluded that: 1) The divergence of political influence that ulama and dayah have in the implementation of the electoral political constellation is very large, many people folllow or make ulama as a reference in determining their choice of politilal partiles in the general election in East Aceh Regency. 2) In providing support to political parties or election participants, ulama and dayah have causes or driving factors that cause divergence in poliltical support from ulama and dayah towards political parties in the implementation of elelctoral politilcs in East Aceh Regency.
Farmers' Perceptions of the Farmer's Card Program in the Distribution of Subsidized Fertilizer
Authors: Hendrita Vivi , Supriyanti Juli , Arief Syuhada Fildza , Komala Refika 
Published: July 2024

In order to support Indonesian agriculture, the Indonesian Government through the Ministry of Agriculture issued the Farmer Card Program. The Tani Card is a debit card issued by banks as a transaction tool for the redemption of subsidized fertilizer at designated official kiosks. The farmer's card program aims to ensure that the distribution of subsidized fertilizer is right on target and facilitates supervision that is directly integrated with SIMPI. This research aims to find out how farmers perceive the use of farmer cards in distributing subsidized fertilizer. The research period was carried out from August to September 2023. This type of research is qualitative descriptive research with a survey method. The research respondents were selected purposively, namely 48 farmers who had received farmer cards for the distribution of subsidized fertilizer. qualitative descriptive data analysis and using a Likert scale. From the research results, it can be concluded that farmers' perceptions of the farmer's card program in distributing subsidized fertilizer as a whole are in the good category with an index of 77.08% or an average of 3.85, then farmers' perceptions of the procedure for obtaining farmer's cards are in the quite good category with an index of 58 .3% or an average of 2.91, then the farmer's perception of the ease of using the farmer's card is in the good category with an index of 65% or an average of 3.25. Furthermore, the farmer's perception of the use of the farmer's card is in the good category with an index of 64.16% or the average -average 3.2. This shows that the farmer's card program in the distribution of subsidized fertilizer in the Sijunjung sub-district has received quite a good perception from the community, even though there are still obstacles experienced by farmers in this farmer's card program in the field
An Update on Emerging Techniques and Considerations in Revision Anterior Cruciate Ligament Reconstruction
Authors: Quinn Matthew , Lemme Nicholas , Morrissey Patrick , Fadale Paul , Owens Brett D. 
Published: July 2024

» The rate of primary anterior cruciate ligament reconstruction (ACLR) failure in at-risk populations remains unacceptably high and necessitates thorough evaluation of native alignment and concomitant injuries.» Posterior tibial slope of >12° is a substantial risk factor of ACLR failure and should be corrected through anterior closing wedge osteotomy.» Varus malalignment of >5° exacerbates stress on the ACL graft, increases ACLR failure risks, and should be considered for correction through high tibial osteotomy at the time of revision ACLR.» Injuries to the anterolateral ligamentous complex are prevalent in ACL ruptures, and high-risk patients have shown benefit from anterolateral ligament reconstruction or lateral extra-articular tenodesis in the revision setting.» Addressing posterolateral corner, collateral ligament, and meniscal injuries, during revision ACLR, is vital to mitigate increased graft forces and optimize knee stability and functional outcomes.
Defective kinase activity of IKKα leads to combined immunodeficiency and disruption of immune tolerance in humans
Authors: Cildir Gokhan , Aba Umran , Pehlivan Damla , Ipsir Canberk , Arik Elif , Warnock Nicholas , Bozkurt Ceren , Tekeoglu Sinem , Tvorogov Denis , Inal Gaye , Cesur Mahmut , Kucukosmanoglu Ercan , Karahan Ibrahim , Savas Berna , Balci Deniz , Yaman Ayhan , Demirbas Nazli Deveci , Tezcan Ilhan , Haskoloğlu Sule , Doğu Figen , Ikinciogullari Aydan , Keskin Ozlem , Tumes Damon , Kok Chung Hoow , Erman Baran 
Published: July 2024

Abstract

IKKα is a multifunctional serine/threonine kinase that controls various biological processes, either dependent on or independent of its kinase activity. However, the importance of the kinase function of IKKα in human physiology remains unknown since no biallelic variants disrupting its kinase activity have been reported. In this study, we present the first homozygous germline missense variant (c.499G > A, p.G167R) in the kinase domain of the CHUK gene, which encodes IKKα. This variant, referred to as IKKαG167R, was found in three children from two Turkish families. IKKαG167R is located in the activation segment of the kinase domain and affects the conserved Asp-Phe/Leu-Gly (DF/LG) motif responsible for coordinating magnesium atoms for ATP binding. As a result, IKKαG167R abolishes the kinase activity of IKKα, leading to impaired activation of the non-canonical NF-κB pathway. Patients carrying IKKαG167R exhibit a range of immune system abnormalities, including the absence of secondary lymphoid organs, hypogammaglobulinemia, significantly reduced populations of memory T and B, MAIT, NK, Tfh, and Treg cells, and limited diversity of T and B cell receptors with evidence of autoreactivity. These patients also demonstrate heightened susceptibility to viral, bacterial, and fungal infections. Overall, our findings indicate that, unlike a nonsense IKKα variant that results in early embryonic lethality in humans due to skeletal and skin abnormalities, the deficiency of IKKα's kinase activity is compatible with human life. However, it significantly disrupts the homeostasis of the innate and adaptive immune systems, underscoring the essential and non-redundant kinase function of IKKα in humans.
Flexible, Stable and Self-Powered Two-Dimensional Layered Nanocomposites (PANI@MoS2) for Trace Ammonia Gas Detection
Authors: Chen Cheng , Tu Qian , Zhou Xin , Xu Jiaxin , Lv Caihong , Ke Xianwen , Li Houbin , Chen Liangzhe , Liu Xinghai 
Published: July 2024

Abstract

In this paper, two-dimensional layered PANI@MoS2 composite with promising energy storage and NH3-sensitive sensing properties has been synthesized by one-step hydrothermal and in-situ growth technique, and their joint application in supercapacitor and NH3 sensing detection is realized. The 2D layered MoS2, produced by incorporating NH4+, possess a high specific surface area and numerous reactive sites, leading to the growth and polymerization of aniline between its layers. Because of the unique layered structure facilitating rapid reversible diffusion of charge ions, the energy storage properties of composites have been significantly improved, and the assembled asymmetric supercapacitors (ASC) can power a LED bulb for more than 20 minutes. Furthermore, due to the formation of p-n heterojunction and Schottky barrier between PANI and MoS2, as well as the enhancement of PANI's structure and dispersion via polystyrene sulfonic acid (PSS) along with nylon filter membrane, the resulting PANI-PSS@MoS2 sensing film shows outstanding ammonia sensitivity and excellent stability. Ultimately, the sensor film and LED bulb is powered by the ASC to achieve a semi-quantitative, real-time detection of NH3 concentration of spoiled food and exhaled gas of patients. The self-powered sensing device, utilizing PANI@MoS2, is anticipated to be an important candidate in flexible wearable sensing arena.
The role of environmentally mediated drug resistance in facilitating the spatial distribution of residual disease.
Authors: Picco Noemi , Milne Amy , Maini Philip , Anderson Alexander 
Published: July 2024

Abstract

The development of de novo resistance is a major disadvantage in molecularly targeted therapies and is an open field of research. While most of the current understanding of the emergence of resistance is focused on cell-intrinsic mechanisms, we know the microenvironment plays a crucial role. Here, we focus on interactions between cancer cells and cancer associated fibroblasts (CAFs) to understand the local crosstalk facilitating residual disease. We model these spatial dynamics with a hybrid-discrete-continuum model. The stress response caused by treatment with molecular inhibitors can trigger a signal for assistance to which CAFs respond. Introducing breaks in treatment allows the microenvironment to normalise as the stress response subsides. We investigate how fluctuating environmental conditions shape the local crosstalk and, ultimately, the resulting residual disease. We find that treatment response depends on the complex interactions between the cancer cells and CAFs, modulated by local concentrations of drug and signalling molecules. With our model we investigate in silico how processes operating at different spatial and temporal scales result in a local environment that enables survival. This work provides a better understanding of the mechanisms that drive the creation of localised residual disease, crucial to informing the development of more effective treatment protocols.
Pre-Conception Dyslipidemia and risk for preeclampsia in women undergoing IVF-ET
Authors: Chen Shaomin , Wang Yang , Wang Zhaoyu , Tao Liyuan , Wang yongqing , wei yuan , Li Zhaoping , Li Rong 
Published: July 2024

Abstract

This study investigated the relationship between dyslipidemia prior to conception and the risk of preeclampsia (PE) in women pregnant by in vitro fertilization and embryo transfer (IVF-ET). The retrospective cohort study consisted of 2994 women who conceived by IVF-ET and delivered live neonates. The study population was divided into two components: a training set for the prediction model development (2288 women) and a test set for validation (706 women). Multivariable logistic regression was used for the development and validation of predictive model for the risk of PE. Among the 2288 women in the training set, 266 women (11.6%) developed PE. Multiple logistic regression analysis identified independent predictors for PE: triglyceride (TG) [adjusted odds ratio (aOR) 1.284; 95% confidence interval (CI) 1.113–1.489, P < 0.001]; pre-pregnancy BMI; pre- chronic hypertension; twin pregnancy; protocol of IVF. These independent predictors for PE were used to form a risk prediction model, and the area under the receiver-operator characteristic (ROC) curve (AUC) in the training and the test set was 0.77 and 0.71, respectively. In conclusion, higher TG levels before pregnancy were independently associated with the risk for PE in women pregnant by IVF-ET.
Systematic Review on Aspect-Based SentimentAnalysis in Cross-Domain
Authors: Santin René Vieira , Rezende Solange Oliveira 
Published: July 2024

Abstract

Aspect-level sentiment analysis is crucial for consumers and institutions, enabling them to monitor satisfaction regarding specific aspects of products and services through user reviews. Over time, various artificial intelligence techniques have been implemented with significant success. However, most of these techniques rely heavily on a substantial amount of labeled data. In this context, Cross-Domain Aspect-Based Sentiment Analysis (ABSA) emerges, leveraging data from source domains to enhance performance in the target domain. This systematic review contributes to this framework by outlining the primary solutions developed to tackle this challenge. It presents their data sources, compared methods, and the evolution of the main technologies adopted while identifying gaps that may inspire future research endeavors. A new classification of models is proposed here, considering the cross-domain approach. This fresh perspective aims to assist researchers in their quest for innovation, clarifying the context of their proposal and suggesting relevant comparisons with existing works.
Determination of Heavy Metals in Commonly Used Tibetan Pharmaceutical Preparations and Herbs by ICP-MS and Health Risk Assessment
Authors: yang yue , zhu tingting , an juhong , qiu weishan , zhong shihong 
Published: July 2024

Abstract

In order to explore the content of heavy metals in commonly used Tibetan medicine preparations and medicinal materials and the possible health risks caused by human ingestion, this study determined the content of heavy metals in 8 kinds of commonly used Tibetan medicine preparations and 18 kinds of medicinal materials, analyzed the excessive content of heavy metals, and evaluated their health risks to human beings. The content of eight heavy metals (Pb, Cd, As, Cu, Hg, Co, Ni and Mn) in each sample were determined by inductively coupled plasma mass spectrometry (ICP-MS). Health risk assessment was performed by calculating the maximum estimated daily intake ( EDI ), target hazard quotient ( THQ ) and non-carcinogenicity assessment method hazard quotient ( HQ ). The results showed that in the comparison of the maximum limit standard of heavy metals stipulated in the ' Chinese Pharmacopoeia ' 2020 edition and the green industry standard, As in one sample of Tibetan medicine preparations exceeded the standard ; there were 2 samples with Pb exceeded the standard, 3 samples with Cd exceeded the standard, 1 sample with As exceeded the standard, and 1 sample with Cu exceeded the standard. When the THQ value and EDI were used as evaluation indexes, the heavy metals contained in the samples had no obvious health hazards to the human health; when HQ value is used as the evaluation indicator, some samples have certain effects on human health. The research results can provide a scientific basis for the safety evaluation of Tibetan medicine preparations and medicinal materials, and promote the standardization of the quality standards of Tibetan medicine.
Interpretable machine learning reveals a diverse arsenal of anti-defenses in 1 bacterial viruses
Authors: Polz Martin , Lopatina Anna , Ferenc Mariusz , Bartlau Nina , Wolfram Michael , Steensen Kerrin , Muscia Sebastiano , Hussain Fatima , Schnurer Madeleine , Afjehi Leila , Pollak Shaul 
Published: July 2024

Abstract

Antagonistic interactions with viruses are an important driver of the ecology and evolution of bacteria, and associating genetic signatures to these interactions is of fundamental importance to predict viral infection success. Recent studies have highlighted that bacteria possess a large, rapidly changing arsenal of defense genes and that viruses can neutralize at least some of these genes with matching anti-defenses. However, a broadly applicable approach for discovering the genetic underpinnings of such interactions is missing since typically used methods such as comparative genomics are limited by the rampant horizontal gene transfer and poor annotation of viral and bacterial genes. Here we show that genes that allow the viruses to overcome bacterial defenses can be systematically identified using an interpretable machine-learning approach even when using diverse bacteria-virus infection data. To verify the predictions, we experimentally characterized eight previously unknown anti-defense proteins in viruses specific for Vibrio bacteria and showed that they counteract a wide range of bacterial immune systems, including AbiH, AbiU, Septu, DRT, CBASS, and Retron. The power of our computational approach is highlighted by the identification of anti-defense proteins that inhibit non-homologous defense systems, which we verify for Retron and AbiH. We suggest that the computational prediction based on experimental interactions offers a promising avenue to unravel the genetic mechanisms of co-evolution between bacteria and their viruses.
The Development and Validation of the Comprehensive Assessment Tool for Challenges in Hemophilia (CATCH) 2.0
Authors: Decker-Palmer Marquita , Mathias Susan D , Crosby Ross D , Colwell Hilary H , Gentile Brittany , Chupka Janet , Recht Michael , Shapiro Amy , Sidonio Robert , Zazzali James L 
Published: July 2024

Abstract

Background
The Comprehensive Assessment Tool of Challenges in Hemophilia (CATCH) was initially developed in 2018 and includes three versions: pediatric, adult, and caregiver. The original versions are lengthy, and scoring can be complex and time-consuming. Therefore, we developed and validated abbreviated versions of the CATCH (referred to as 2.0) and present data supporting their factor structure, reliability, and validity.
Methods
The analysis pooled data from three studies (N = 126 children, 232 adults, and 118 caregivers) and included individuals with hemophilia A and B. Clinical experts provided feedback regarding potential individual items for deletion, and exploratory factor analysis (EFA) was performed after selected items were removed. Confirmatory factor analysis (CFA) was used to evaluate measurement invariance of the CATCH 2.0. Reliability and validity were assessed using criterion measures; responsiveness was evaluated using the standard effect size and standardized response mean. We endeavored to estimate clinically meaningful change for each scale of the CATCH 2.0.
Results
The adult version of the CATCH 2.0 demonstrated good validity and reliability, with an excellent factor structure and evidence that it is appropriate for use with both hemophilia type A and type B. While the factor structure of the Pediatric and Caregiver versions was excellent, some measurement properties could not be established (e.g., test-retest reliability, known-groups validity, responsiveness), in part due to small sample sizes. Additionally, it was not possible to estimate anchor-based clinically meaningful changes for the three versions due to a lack of appropriate anchors.
Conclusions
The CATCH 2.0 is a more accessible self-report version of CATCH 1.0 and has adequate psychometric properties for most scales and versions. The reliability and validity demonstrated by these results, along with its brevity, should permit its use in both clinical research and practice.
Exploring the carbon sequestration of an asphalt base course mixture containing novel cold-bonded biochar-rich lightweight aggregates
Authors: Grossegger Daniel , Wyrzykowski Mateusz , Toropovs Nikolajs , Lura Pietro 
Published: July 2024

Abstract

An emerging strategy to compensate for the greenhouse gas emissions of products is to incorporate carbonaceous materials obtained from sequestered atmospheric carbon dioxide, mainly obtained through biomass conversion. This approach can turn asphalt pavements into a functional carbon sink. In particular, biochar has been used as a bitumen modifier. However, due to performance limitations, carbonaceous materials were only added in small quantities to asphalt mixtures. An alternative approach is to produce lightweight aggregates to substitute a part of the mineral aggregates of the asphalt mixture. To this end, biochar is pelletised with a hydraulic binder and water in a cold-bonding process, forming spherical pellets labelled as carbon-rich lightweight aggregates (C-LWA). Like other lightweight aggregates, C-LWA showed a reduced mechanical strength compared to conventional mineral aggregates, adversely affecting the asphalt mixture performance. Cracking and rutting resistance almost linearly decreased with C-LWA content. The direct addition of biochar had a similar adverse influence on the mixture performance. Despite a reduced performance, adding biochar and C-LWA reduces the greenhouse gas emissions of asphalt mixtures. Net-zero emissions were estimated for the produced asphalt mixture by adding 5.5 ± 0.4% C-LWA or 3.0 ± 0.2% biochar.