bluuebunny/crossref_metadata_2025_split huggingface dataset:
Pilot Trial of Selecting Molecularly Guided Therapy for Patients with Non–V600 BRAF-Mutant Metastatic Melanoma: Experience of the SU2C/MRA Melanoma Dream Team
Authors: LoRusso Patricia M. , Boerner Scott A. , Pilat Mary Jo , Forman Karen M. , Zuccaro Clarice Y. , Kiefer Jeffrey A. , Liang Winnie S. , Hunsberger Sally , Redman Bruce G. , Markovic Svetomir N. , Sekulic Aleksandar , Bryce Alan H. , Joseph Richard W. , Cowey C. Lance , Fecher Leslie Anne , Sosman Jeffrey Alan , Chapman Paul B. , Schwartz Gary K. , Craig David W. , Carpten John D. , Trent Jeffrey M. 
Published: June 2015

Abstract
Targeted therapies and immunotherapies have led to significant improvements in the treatment of advanced cancers, including metastatic melanoma. However, new strategies are desperately needed to overcome therapeutic resistance to these agents, as well as to identify effective treatment approaches for cancer patients that fall outside major targetable mutational subtypes (e.g., non–V600 BRAF melanoma). One such strategy is to extend the paradigm of individually tailored, molecularly targeted therapy into a broader spectrum of melanoma patients, particularly those bearing tumors without commonly recognized therapeutic targets, as well as having failed or were ineligible for immunotherapy. In this nontreatment pilot study, next-generation sequencing (NGS) technologies were utilized, including whole genome and whole transcriptome sequencing, to identify molecular aberrations in patients with non–V600 BRAF metastatic melanoma. This information was then rationally matched to an appropriate clinical treatment from a defined pharmacopeia. Five patients with advanced non–V600 BRAF metastatic melanoma were enrolled. We demonstrated successful performance of the following during a clinically relevant time period: patient tumor biopsy, quality DNA/RNA extraction, DNA/RNA-based sequencing for gene expression analysis, analysis utilizing a series of data integration methodologies, report generation, and tumor board review with formulated treatment plan. Streamlining measures were conducted based on the experiences of enrolling, collecting specimens, and analyzing the molecular signatures of patients. We demonstrated the feasibility of using NGS to identify molecular aberrations and generate an individualized treatment plan in this patient population. A randomized treatment study utilizing lessons learned from the conduct of this pilot study is currently underway. Mol Cancer Ther; 14(8); 1962–71. ©2015 AACR.
Transdifferentiation of erythroblasts to megakaryocytes using FLI1 and ERG transcription factors
Authors: Siripin Darin , Kheolamai Pakpoom , U-Pratya Yaowalak , Supokawej Aungkura , Wattanapanitch Methichit , Klincumhom Nuttha , Laowtammathron Chuti , Issaragrisil Surapol 
Published: June 2015

SummaryPlatelet transfusion has been widely used to prevent and treat life-threatening thrombocytopenia; however, preparation of a unit of concentrated platelet for transfusion requires at least 4–6 units of whole blood. At present, a platelet unit from a single donor can be prepared using apheresis, but lack of donors is still a major problem. Several approaches to produce platelets from other sources, such as haematopoietic stem cells and pluripotent stem cells, have been attempted but the system is extremely complicated, time-consuming and expensive. We now report a novel and simpler technology to obtain platelets using transdifferentiation of human bone marrow erythroblasts to megakaryocytes with overexpression of the FLI1 and ERG genes. The obtained transdifferentiated erythroblasts (both from CD71+ and GPA+ erythroblast subpopulations) exhibit typical features of megakaryocytes including morphology, expression of specific genes (cMPL and TUBB1) and a marker protein (CD41). They also have the ability to generate megakaryocytic CFU in culture and produce functional platelets, which aggregate with normal human platelets to form a normal-looking clot. Overexpression of FLI1 and ERG genes is sufficient to transdifferentiate erythroblasts to megakaryocytes that can produce functional platelets.
АЛГОРИТМ КЛАСИФІКАЦІЇ ПОЛІТРАВМ МЕТОДОМ ІНДУКЦІЇ ДЕРЕВА РІШЕНЬ
Authors: Borys R. M. , Martsenyuk V. P. 
Published: June 2015

<p class="a0">The work program is developed and implemented induction decision tree method for classification of polytrauma based on a number of biochemical parameters.</p><p class="a0">The selection algorithm uses the value of the attribute information gain. The project was implemented in the medium</p><p class="a0">Netbeans Java-based classes.</p>
Echocardiographic and Hemodynamic Predictors of Survival in Precapillary Pulmonary Hypertension
Authors: Grapsa Julia , Pereira Nunes Maria Carmo , Tan Timothy C. , Cabrita Ines Zimbarra , Coulter Taryn , Smith Benjamin C.F. , Dawson David , Gibbs J. Simon R. , Nihoyannopoulos Petros 
Published: June 2015

Background—
In this study, we looked at the prognostic value of echocardiographic and hemodynamic measures in a large cohort of patients with precapillary pulmonary hypertension before and after initiation of treatment.

Methods and Results—

Data were collected prospectively in a cohort of consecutive patients with precapillary pulmonary hypertension referred between 2002 and 2011. A range of clinical and echocardiographic variables were collected and stored on a database to assess predictors of survival. Invasive hemodynamic data including pulmonary artery pressure, pulmonary vascular resistance, capillary wedge pressure, and cardiac index were also obtained at baseline in all patients. Outcome was defined as mortality because of cardiovascular-related death. The study cohort comprised 777 patients (514 women) with precapillary pulmonary hypertension. A total of 195 (25%) died. In multivariable analysis, moderate or severe tricuspid regurgitation (hazard ratio [HR], 26.537; 95% confidence interval, 11.536–61.044;
P
<0.001), right ventricular myocardial performance index (HR, 3.421; 95% confidence interval, 1.777–6.584;
P
<0.001), and the presence of pericardial effusion (HR, 1.38; 95% confidence interval, 1.023–1.862;
P
=0.035) were independent predictors of mortality. High pulmonary vascular resistance and right atrial pressure by invasive hemodynamic measurements were independent predictors of mortality (HR, 1.084; 95% confidence interval, 1.041–1.130, and 1.079, respectively; 95% confidence interval, 1.049–1.111;
P
<0.001 for both), whereas patients with a higher cardiac index had better survival overall (HR, 0.384; 95% confidence interval, 0.307–0.481;
P
<0.001).

Conclusions—
Right ventricular dysfunction, moderate–severe tricuspid regurgitation, low cardiac index, and raised right atrial pressure were associated with poor survival for both pulmonary arterial hypertension and chronic thromboembolic pulmonary hypertensive disease patients. The severity of tricuspid regurgitation, myocardial performance index, presence of pericardial effusion, pulmonary vascular resistance, cardiac index, and right atrial pressure may be used to stratify risk of death.
Evaluation of Regional-Scale River Depth Simulations Using Various Routing Schemes within a Hydrometeorological Modeling Framework for the Preparation of the SWOT Mission
Authors: Häfliger Vincent , Martin Eric , Boone Aaron , Habets Florence , David Cédric H. , Garambois Pierre-A. , Roux Hélène , Ricci Sophie , Berthon Lucie , Thévenin Anthony , Biancamaria Sylvain 
Published: June 2015

AbstractThe Surface Water and Ocean Topography (SWOT) mission will provide free water surface elevations, slopes, and river widths for rivers wider than 50 m. Models must be prepared to use this new finescale information by explicitly simulating the link between runoff and the river channel hydraulics. This study assesses one regional hydrometeorological model’s ability to simulate river depths. The Garonne catchment in southwestern France (56 000 km2) has been chosen for the availability of operational gauges in the river network and finescale hydraulic models over two reaches of the river. Several routing schemes, ranging from the simple Muskingum method to time-variable parameter kinematic and diffusive waves schemes, are tested. The results show that the variable flow velocity schemes are advantageous for discharge computations when compared to the original Muskingum routing method. Additionally, comparisons between river depth computations and in situ observations in the downstream Garonne River led to root-mean-square errors of 50–60 cm in the improved Muskingum method and 40–50 cm in the kinematic–diffusive wave method. The results also highlight SWOT’s potential to improve the characterization of hydrological processes for subbasins larger than 10 000 km2, the importance of an accurate digital elevation model, and the need for spatially varying hydraulic parameters.
MR Diagnosis of Retropatellar Chondral Lesions under Compression
Authors: Andresen R. , Radmer S. , König H. , Banzer D. , Wolf K.-J. 
Published: June 2015

Purpose: The aim of the study was to improve the chondromalacia patellae (CMP) diagnosis by MR imaging under defined compression of the retropatellar cartilage, using a specially designed knee compressor. The results were compared with histological findings to obtain an MR classification of CMP. Method: MR imaging was performed in in vitro studies of 25 knees from cadavers to investigate the effects of compression on the retropatellar articular cartilage. The results were verified by subsequent histological evaluation. Results: There was a significant difference in cartilage thickness reduction and signal intensity behaviour under compression according to the stage of CMP. Conclusion: Based on the decrease in cartilage thickness, signal intensity behaviour under compression, and cartilage morphology, the studies permitted an MR classification of CMP into stages I—IV in line with the histological findings. Healthy cartilage was clearly distinguished, a finding which may optimize CMP diagnosis.
Petrous Bone Extension of Middle-Ear Acquired Cholesteatoma
Authors: Robert Y. , Dubrulle F. , Carcasset S. , Hennequin C. , Gaillandre L. , Vanecloo F.-M. , Lemaitre L. 
Published: June 2015

Purpose: To describe CT and MR features of extension to the petrous bone, which is a rare complication of acquired cholesteatoma (AC). Material and Methods: Postcontrast CT was performed in 4 patients, in axial (n=4) and coronal planes (n=2). The section thickness was 1.2 or 2.5 mm. MR was performed in 3 cases, using T1- and T2-weighted images (n=3) and postcontrast T1-weighted images (n=2). Results: CT demonstrated a well-outlined lesion involving the petrous bone (n=4). Density could be assessed in 3 cases, showing a hypodense unenhanced mass. Lateral (n=1), superior (n=2), and posterior (n=2) semicircular canals were affected in 3 patients. AC extended to the vestibula, cochlea, and internal acoustic meatus (IAM) in 3 patients. Two ACs extended to the level of IAM, whereas 2 extended further, to the petrous apex. In one case the sphenoid sinus was affected. On MR imaging the lesion was hypointense relative to brain on T1-weighted images and hyperintense on T2-weighted images. MR imaging helped to delineate the lesion and to distinguish it from other cystic lesions of the petrous bone. Conclusion: CT and MR offer accurate preoperative assessment of the extension of cholesteatoma, which helps to choose the surgical approach.
Dermatofibrosarcoma Protuberans
Authors: Miyakawa E. , Fujimoto H. , Miyakawa K. , Nemoto K. , Kozawa K. , Sugano I. , Odani Y. , Hirata T. , Ogata H. , Ohno T. 
Published: June 2015

Purpose: To characterize the CT findings of dermatofibrosarcoma protuberans. Material and Methods: CT and pathologic specimens of 6 patients with dermatofibrosarcoma protuberans (5 in the trunk and 1 in the leg) were retrospectively reviewed. Results: CT clearly defined the tumors in the dermis and subcutaneous tissue with a characteristic, if not pathognomonic, protrusion. On postcontrast CT, 3 tumors showed marginal enhancement and central low density, while the others showed homogeneous enhancement. Pathologically, the marginal enhancement on CT corresponded to fibrosarcomatous changes, and the central low density to necrosis. The tumors with homogeneous enhancement had no sarcomatous changes. Conclusion: CT allows detection and precise anatomic localization of dermatofibrosarcoma protuberans. Marginal enhancement with central low density on CT may suggest a relatively poor prognosis.
Elimination of Low-Osmolality Contrast Media by Hemodialysis
Authors: Furukawa T. , Ueda J. , Takahashi S. , Sakaguchi K. 
Published: June 2015

Purpose: To compare the dialyzability and safety of 2 types of low-osmolality contrast media administered to end-stage renal failure patients maintained on regular hemodialysis. Material and Methods: Of 44 CT examinations, iohexol was used in 22 and ioxaglate in the other 22. Adverse reactions and hemodynamic changes were recorded. Thirty minutes after the beginning of CT investigation, hemodialysis was commenced. Elimination rate and clearance of the contrast media were measured as indices of their dialyzability. Results: After 4 hours of hemodialysis, 78.4±6.5% of iohexol and 72.4±6.0% ioxaglate were eliminated. Clearance of iohexol was higher than that of ioxaglate at all sampling times. No severe hemodynamic change nor adverse reaction were observed. Minor reactions were more frequently observed in the ioxaglate group. Conclusion: Iohexol, a nonionic monomeric contrast medium, is more advantageous for hemodialysis patients than ioxaglate, an ionic dimeric contrast medium.
Complications following High-Dose Percutaneous Ethanol Injection into Hepatic Tumors
Authors: Tapani E. , Soiva M. , Lavonen J. , Ristkari S. , Vehmas T. 
Published: June 2015

Purpose: Percutaneous ethanol injection therapy (PEIT) with a 2–10 ml ethanol dose per session is widely used in the treatment of small hepatocellular carcinoma. Larger doses have been restricted for fear of complications. The aim of the present study was to make a retrospective evaluation of the complications following treatment of hepatic tumors with high doses of ethanol (up to 200 ml). Material and Methods: The medical records of 15 patients treated repeatedly with PEIT were reviewed retrospectively to detect side effects or complications. Eleven of these patients had undergone transarterial chemoembolization (TAE) prior to PEIT. Of 173 ethanol injections in doses of 2–200 ml (mean 49 ml), more than 10 ml had been injected on 138 occasions. The chi-square test was used to evaluate the differences in pain frequency among the various dosage groups. Results: Serious complications did not occur. Pain was a common side effect, occurring in 48% of the procedures. Immediate pain during the treatment was related to the ethanol dose and increased significantly with increasing doses (p<0.01). Other side effects were rare. Conclusion: PEIT with doses higher than previously reported seems to be safe. This should encourage further clinical studies that aim at fully working out the clinical value of such treatment.
Thyroid Ultrasound Findings 7 Years after the Chernobyl Accident
Authors: Kumpusalo L. , Kumpusalo E. , Soimakallio S. , Salomaa S. , Paile W. , Kolmakow S. , Zhukowsky G. , Ilchenko I. , Nissinen A. 
Published: June 2015

Aims: The accident at the Chernobyl nuclear power station occurred in April 1986. We report on a comparative epidemiological study on thyroid abnormalities in the contaminated and uncontaminated populations of the Bryansk region, South-West Russia, in 1993, 7 years after the accident. Material and Methods: The study material consisted of all inhabitants aged 3–34 years in the contaminated village of Mirnyi and in the uncontaminated village of Krasnyi Rog, excluding those who had moved to the villages after the accident. The total material comprised 302 inhabitants in Mirnyi and 200 in Krasnyi Rog. Results: No pathological US findings in either village were found in children born after the accident. In the age group 0–9 years old at the time of the accident, the prevalence of thyroid abnormalities was 8.1% in the contaminated village compared to 1.6% in the uncontaminated village. In the age group 10–27 years the corresponding figures were 18.8% and 17.7%. Only 55% of the pathological US findings were detected by physical palpation. Conclusion: The total prevalence of thyroid abnormalities was higher among children in the contaminated village. We recommend an active screening of young contaminated subjects with US, supplemented with fine needle biopsy.
Nilotinib combined with multiagent chemotherapy for newly diagnosed Philadelphia-positive acute lymphoblastic leukemia
Authors: Kim Dae-Young , Joo Young-Don , Lim Sung-Nam , Kim Sung-Doo , Lee Jung-Hee , Lee Je-Hwan , Kim Dong Hwan (Dennis) , Kim Kihyun , Jung Chul Won , Kim Inho , Yoon Sung-Soo , Park Seonyang , Ahn Jae-Sook , Yang Deok-Hwan , Lee Je-Jung , Lee Ho-Sup , Kim Yang Soo , Mun Yeung-Chul , Kim Hawk , Park Jae Hoo , Moon Joon Ho , Sohn Sang Kyun , Lee Sang Min , Lee Won Sik , Kim Kyoung Ha , Won Jong-Ho , Hyun Myung Soo , Park Jinny , Lee Jae Hoon , Shin Ho-Jin , Chung Joo-Seop , Lee Hyewon , Eom Hyeon-Seok , Lee Gyeong Won , Cho Young-Uk , Jang Seongsoo , Park Chan-Jeoung , Chi Hyun-Sook , Lee Kyoo-Hyung 
Published: June 2015

Key Points
Nilotinib plus multiagent chemotherapy was feasible and showed a comparable outcome to previous results with imatinib for Ph-pos ALL. The achievement of deep MR with nilotinib at postremission correlated well with the clinical outcomes for Ph-pos ALL.
Treatment with agonistic DR3 antibody results in expansion of donor Tregs and reduced graft-versus-host disease
Authors: Kim Byung-Su , Nishikii Hidekazu , Baker Jeanette , Pierini Antonio , Schneidawind Dominik , Pan Yuqiong , Beilhack Andreas , Park Chung-Gyu , Negrin Robert S. 
Published: June 2015

Key PointsDonor treatment with agonistic DR3 antibody induces selective expansion of Tregs and reduced activation of conventional T cells. T cells from DR3 antibody–treated donors result in reduced acute GVHD and preserved GVT effects.
The Treatment of Cushing's Disease
Authors: Pivonello Rosario , De Leo Monica , Cozzolino Alessia , Colao Annamaria 
Published: June 2015

AbstractCushing's disease (CD), or pituitary-dependent Cushing's syndrome, is a severe endocrine disease caused by a corticotroph pituitary tumor and associated with increased morbidity and mortality. The first-line treatment for CD is pituitary surgery, which is followed by disease remission in around 78% and relapse in around 13% of patients during the 10-year period after surgery, so that nearly one third of patients experience in the long-term a failure of surgery and require an additional second-line treatment. Patients with persistent or recurrent CD require additional treatments, including pituitary radiotherapy, adrenal surgery, and/or medical therapy. Pituitary radiotherapy is effective in controlling cortisol excess in a large percentage of patients, but it is associated with a considerable risk of hypopituitarism. Adrenal surgery is followed by a rapid and definitive control of cortisol excess in nearly all patients, but it induces adrenal insufficiency. Medical therapy has recently acquired a more important role compared to the past, due to the recent employment of novel compounds able to control cortisol secretion or action. Currently, medical therapy is used as a presurgical treatment, particularly for severe disease; or as postsurgical treatment, in cases of failure or incomplete surgical tumor resection; or as bridging therapy before, during, and after radiotherapy while waiting for disease control; or, in selected cases, as primary therapy, mainly when surgery is not an option. The adrenal-directed drug ketoconazole is the most commonly used drug, mainly because of its rapid action, whereas the glucocorticoid receptor antagonist, mifepristone, is highly effective in controlling clinical comorbidities, mainly glucose intolerance, thus being a useful treatment for CD when it is associated with diabetes mellitus. Pituitary-directed drugs have the advantage of acting at the site responsible for CD, the pituitary tumor. Among this group of drugs, the dopamine agonist cabergoline and the somatostatin analog pasireotide result in disease remission in a consistent subgroup of patients with CD. Recently, pasireotide has been approved for the treatment of CD when surgery has failed or when surgery is not an option, and mifepristone has been approved for the treatment of Cushing's syndrome when associated with impairment of glucose metabolism in case of the lack of a surgical indication. Recent experience suggests that the combination of different drugs may be able to control cortisol excess in a great majority of patients with CD.
eINTERASIA Project: IT Transfer Concept for Adaptation and Dissemination of Innovative European Research Results in Central Asian Countries
Authors: Novickis Leonids , Mitasiunas Antanas 
Published: June 2015

Abstract
The paper presents an overview of the eINTERASIA international project aimed at supporting international cooperation with Central Asian countries by transfer, adaptation and dissemination of European research results in the area of Information Technology and Applied Software.
Information Technology Transfer Concept (TTC) based on InnoSPICE approach and Capability Maturity Model has been developed.
The concept of showroom as part of the implementation of TTC has been introduced in the selected Central Asian countries. Technological platforms for demonstrators of Virtual Reality-Based scenarios from Fraunhofer IFF were adapted and installed in the region of Central Asia.
Several EU research projects are selected for adaptation and validation in Central Asian countries. Special attention is devoted to demonstrate transfer and adaptation processes in the area of web-based transport logistics.
Virtual Reality Models and Digital Engineering Solutions for Technology Transfer
Authors: Schumann Marco , Leye Stefan , Popov Artyom 
Published: June 2015

Abstract
Effective applied research is based on close collaboration between research and industry, which taking the findings of basic research on customer demands as its starting point, creates a new means for developing and marketing innovative products. What is more, growing demands for innovative and sustainable results of research and development are prompting the examination of global trends such as demographic change, growing megacities, rising energy consumption and increasing traffic and the resultant social challenges. These trends and increasing traffic in particular are giving rise to new fields of work, especially for digital technologies, as a social responsibility, e.g., in driver assistance and traffic control systems that increase safety.
This paper examines a means by which digital engineering, virtual and augmented reality technologies can support the creation of sustainable smart manufacturing and smart logistics processes as well as on-the-job training and qualification and knowledge transfer.
Fiscal shocks, the real exchange rate and the trade balance: some evidence for emerging economies
Authors: da Silva Marcelo Eduardo Alves , Baerlocher Diogo , de Paiva Fonseca Henrique Veras 
Published: June 2015

AbstractThis paper implements a structural vector auto regression (SVAR) analysis to investigate the impacts and importance of fiscal shocks on the dynamics of the real exchange rate and the trade balance in three emerging economies: Brazil, Chile and Mexico. We show that the effects of an unexpected increase in government spending are not uniform across countries with higher spending leading to a depreciation of the real exchange rate in Brazil and Chile, whereas in Mexico, we observe an appreciation. The trade balance deteriorates in all three countries. We also report that an unexpected increase in taxes leads to recessionary impacts and improves the trade balance. Only in Mexico is there evidence of a real exchange rate depreciation. Finally, we show that fiscal shocks account for roughly 20% of real exchange fluctuations.