bluuebunny/crossref_metadata_2025_split huggingface dataset:
Comparaison of two anterior segment OCT: CASIA (Tomey) versus OCT Visante (Zeiss)
Authors: GIMBERT A , CAMPOLMI N , THURET G , GAIN P , ROMANET JP , CHIQUET C , APTEL F 
Published: November 2013

AbstractPurpose To compare the anterior chamber (AC) and AC angle measurements obtained with a spectral‐domain and a time‐domain anterior segment optical coherence tomography (AS‐OCT), and to evaluate their repeatabilityMethods Prospective cross‐sectional study conducted on healthy subjects. The AC was imaged with a spectral‐domain (Casia SS‐100, Tomey) and a time‐domain AS‐OCT (Visante, Zeiss) in one eye of each patient in a random order. The central corneal thickness (CCT), anterior chamber depth (ACD), angle opening distance at 500 and 700 µm (AOD 500 and AOD 750), trabecular iris space area at 500 and 700 µm (TISA 500 and TISA 750) and scleral spur angle (SSA) were measured. The repeatability measurements were evaluated by the intraclass correlation coefficients (ICCs)Results 101 eyes of healthy subjects were analyzed. The repeatability was excellent with the Casia and the Visante for CCT (ICC 0.90‐0.94 and 0.95‐0.97), ACD (ICC 0.95‐0.98 and 0.93‐0.96), AOD 500 (ICC 0.92‐0.96 and 0.90‐0.94) and 750 (ICC 0.93‐0.96 and 0.91‐0.94), TISA 750 (ICC 0.81‐0.97 and 0.9‐0.94) and SSA (ICC 0.9‐0.94 and 0.89‐0.94), and moderate for TISA 500 (ICC 0.68‐0.97 and 0.7‐0.93). For all parameters, Casia and Visante measurements were significantly correlated (r 0.76‐0.98; p<0.002). Differences were non‐significant for CCT, AOD500 and 750, TISA 500 and 750. ACD measured with Casia was significantly larger than that measured with the Visante, and SSA measured with Casia was significantly lower than that measured with VisanteConclusion Both Casia and Visante AS‐OCTs demonstrate high repeatability. Excepted for the ACD and SSA, the two AS‐OCTs agree well in AC and AC angle measurements
Inter‐test variability in normals and glaucomatous patients tested by Optopol PTS‐910, Glaucoma program
Authors: POPA CHERECHEANU A , DASCALU AM , STANA D , SERBAN D 
Published: November 2013

AbstractPurpose To quantify the inter‐test variability (dB) for the Optopol automated perimeter, Glaucoma Fast Treshold program, in normals and glaucoma patients.Methods A prospective study was performed on 204 glaucoma patients and a control group of 30 normal subjects, tested by complete ophthalmological exam and automated perimetry (Optopol PTS‐910). The visual field was tested weekly for 4 consecutive weeks, using the Glaucoma Fast Threshold strategy. The visual field defects were classified according to the Aulhorn‐Karmeyer descriptive scale.Results For the control group, the average inter‐test variability was of 1.57+/‐ 0.24 dB, lower next to fixation and increasing towards the 50 degree isopter. The average inter‐test variability increases along with the perimetric stage: 1.57+/‐0.66 dB for pre‐perimetric glaucoma, 2.13+1.04 dB for non‐specific defects group, 3.23 + 1.01dB for the stage 1, 3.52 + 2.61dB, for the stage 2, 3.65 + 1.19dB for the stage 3 and 5.82 +/‐ 1.67dB for the stage 4. For the cases of preperimetric glaucoma and non‐specific defects, a similar profile of variability as for the normal subjects could be observed. For the stages 2‐4, the profile of the areas with maxim inter‐test variability moves towards the relative scotoma and the surrounding area.Conclusion A better description of the inter‐test variability and the evolution of this intricate parameter of the retinal light sensitivity is useful for the differential diagnostic between the real change and the « background noise » in early detection of the functional progression in glaucoma.
Progression of visual field in patients with primary open‐angle glaucoma (2): Level of progression
Authors: GIRAUD JM , EL CHEHAB H , APTEL F , ARYAL‐CHARLES N , MAY F , CHIQUET C , ROMANET JP , RENARD JP 
Published: November 2013

AbstractPurpose To compare the visual field rate (VF) of progression of non evolutive and evolutive patients with treated ocular hypertension (OHT) or primary‐open angle glaucoma (POAG).Methods From a multicentric database, 441 eyes of 228 patients with treated OHT or POAG followed up at least 6 years with Humphrey 24.2 Sita‐Standard VF exam at least twice a year were identified and classified in 5 groups: 104 OHT, 205 early glaucoma (MD>‐6dB), 45 moderate glaucoma (MD‐6 to ‐12dB), 41 advanced glaucoma (MD‐12 to ‐18dB) and 46 severe glaucoma (MD<‐18dB). With final datas, patients were classified in 2 sub groups: “evolutive” or “stable” patients if worsening or not to upper grade. Rate of progression during follow‐up period was calculated using the trend analysis of the Guided Progression Analysis software.Results The mean follow‐up was 8.4 years. We found respectively for “stable” and “evolutive” sub‐groups, following rates of progression : MD =‐0.01 and ‐0.13dB/year (‐0.03& ‐0.41%VFI/year) in eyes with OHT, ‐0.07& ‐0.80dB/year (‐0.23 & ‐2.39%VFI/year) in early glaucoma group, ‐0.02& ‐0,91 dB/year (‐0.46 & ‐3.04%VFI/year) in moderate glaucoma, ‐0.21 & ‐0.82dB/year (‐1.13 & ‐3.57%VFI/year) in advanced glaucoma.Conclusion In early to advanced stages of glaucoma, “stable” patients showed a low rate of progression, compared to “evolutive” subgroup with a common rate around ‐0.80dB/year. These values could represent a landmark of evolution in glaucoma.
Primary health care model for detection of ophtalmological visual disturbances in a population of employees of Universidad de Tarapaca, Chile
Authors: CHAVEZ C , VETTERLEIN V , RAMIREZ JM , DE HOZ R 
Published: November 2013

AbstractPurpose Implement a primary health care model for the Universidad de Tarapacá personnel in Arica, Chile, which is a desert region.Methods The model was applied at 510 employees and consisted of applying a survey and eye exams such as: Visual acuity for near and far, autorefractometria, biomicroscopy, IOP. In the analysis measures of central tendency, proportions, means and standard deviation were used. The ratio differences were analyzed in in bivariate statistic chi2 and T Student.Results The average age was 48 years old, 57% female and 43% male. The 27% have Aymara ancestry and of these, 13% have ocular disorders. The 18% have systemic diseases and 73% have just one family member with an ocular disease. One of every 4 states to have a diagnosed eye disease. The 50% of the total has 100% of AV without optical devices. The 34% use optical lenses that do not alter their visual acuity. Of those over 40 years old, 3% has IOP above 24 mm Hg, 7% over 21 and 90% less than 21. The 16% has Pterigion symptomatic and 5% are bilateral. The 61% of the total study population reports to feel the need to be assisted an eye professional.Conclusion It is important to take measures for public health action and modify the regional and national public policies of our country through implementation models resolutive primary eye care for improving the access to healthcare systems. This makes better use of the specialized medical resources.
Clinical findings in a Roma family with autosomal dominant cone‐rod dystrophy
Authors: KOEV K , CHERNINKOVA S , KAMENAROVA K , GEORGIEV R , KANEVA R 
Published: November 2013

AbstractPurpose To make a clinical assessment of patients affected by autosomal dominant cone‐rod dystrophy (adCORD).Methods A three‐generation autosomal dominant pedigree of Romani origin with non syndromic CORD was identified. Eight affected and 14 unaffected individuals were clinically ascertained. All affected relatives were studied. Clinical evaluation included best corrected visual acuity determination, funduscopy, Humphrey perimetry, Farnsworth Hue‐28 color testing, fluorescein angiography, and full‐field electroretinogram (ERG).Results All affected individuals presented reduced visual acuity (0.01 ‐ 0.4) and photophobia with slightly variable but early age of onset (around 13 years of age). Funduscopic examination and fluorescein angiography revealed advanced changes including bone spicule‐like pigment deposits in the midperiphery and macular area along with retinal atrophy, narrowing of the vessels, and waxy optic discs. Visual fields demonstrated central scotoma. Electrophysiologic examination of the patients detected an abnormal cone‐rod ERG (20‐30μV) with photopic amplitudes more markedly reduced than the scotopic. Flicker responses were missing and Farnsworth Hue‐28 test found protanopia.Conclusion In this study we report a family of Gypsy origin affected by autosomal dominant cone‐rod dystrophy. Identification of the disease causing gene may eventually contribute to new knowledge on the pathogenesis of this condition.
Retigabine‐induced retinal dystrophy: First reported case
Authors: ASCASO FJ , MAURI JA , MATEO J , CAMACHO JL , DEL BUEY MA , IBAñEZ J , PéREZ D , CRISTóBAL JA 
Published: November 2013

AbstractPurpose A recent FDA warning reported that retigabine (ezogabine in the US), a third‐generation antiepileptic drug introduced in 2011 for the management of refractory epilepsy, can cause blue skin discoloration and retinal pigmentary changes.Our purpose is to present the first documented case of retinal dystrophy secondary to this drug.Methods This case report shows the characteristics of the so‐called "blue person syndrome", such as blue pigmentation around lips, fingernails and toenails. Likewise, the patient developed a bilateral and asymptomatic retinal distrophy confirmed by color and red‐free fundus photographs.Results A 53‐year‐old woman noted blue pigmentation around lips, fingernails and toenails for 6 months. She suffered from refractory epilepsy and underwent 1200 mg daily of retigabine (Trobalt®) for 6 years.BCVA was 20/20 bilaterally. Slit‐lamp examination showed no conjunctival discoloration. IOP, ocular motility, pupillary reactions and color vision test were normal. Ophthalmoscopy revealed bilateral retinal pigmentary changes running outward from the optic disk, with an appearance similar to that seen in angioid streaks. Several grey, fine subretinal branching bands radiated out from an area of peripapillary pigment alteration. Red‐free fundus photographs showed, along the temporal vascular arcades, a thinned and depigmented retina, allowing visualization of underlying choroidal vessels. Visual field testing, fluoresceingraphy, autofluorescence and SD‐OCT were unremarkable.Conclusion Ophthalmologists and neurologists should be aware of the possibility of ophthalmological toxic effects in patients taking retigabine. When such effects are detected, the drug should be discontinued.
Alu retrotransposon quantification in the retina and plasma: Mechanism‐based risk assessment in age‐related macular degeneration
Authors: FOWLER B , KERUR N , GELFAND B , BASTOS‐CARVALHO A , AMBATI J 
Published: November 2013

AbstractPurpose Alu RNAs are endogenous pathogens in age‐related macular degeneration (AMD). Currently, efforts to develop diagnostic and prognostic tools are limited. Yet, because AMD is a chronic disease, tools to detect pre‐clinical disease and monitor progression are an essential part of an effective and comprehensive therapeutic strategy. We tested plasma Alu RNA as a potential biomarker for AMD. Also, cells can convert Alu RNA into DNA, and as such, we determined Alu DNA content of RPE cells. We also genotyped RPE cells for a panel of known AMD risk single nucleotide polymorphisms, and developed an AMD risk stratification system based on age, genotype, and Alu DNA content.Methods RPE cells were isolated from human donor eyes were harvested within 5‐10 hours after death. RPE cells were grown in cell culture for four passages. DNA was extracted and subjected to genotyping for AMD‐associated SNPs using TaqMan probes. Plasma sample RNA was extracted with Trizol LS and reverse transcribed. qPCR for DNA performed with standard curves of Alu‐specific primers and housekeeping single copy genes; for cDNA, Alu quantified per mL plasma.Results The RPE of AMD donors contain increased quantities of Alu DNA. Our results suggest that Alu DNA content increases as a function of age and disease status, and that genotype also modulates disease risk. Finally, Alu RNA content in plasma was significantly increased in AMD versus age‐matched healthy controls.Conclusion These efforts set the stage for the utilization of plasma Alu RNA quantity as a novel mechanism‐based biomarker in AMD, and also implicate increased Alu DNA burden as a potential mediator of Alu RNA‐induced RPE cell death in AMD.
Choroidal thickness in retinitis pigmentosa using EDI OCT
Authors: AKNIN I , MELKI L 
Published: November 2013

AbstractPurpose To describe the choroidal thickness of patients with RP using enhanced depth imaging (EDI) and spectral domain (SD) optical coherence tomography (OCT), comparing with impaired non affected subjects.Methods Prospective, case‐control study of 20 patients with RP imaged using the Spectralis EDI protocol. 40 healthy age‐matched subjects participated in the study as control. RP patients had mild to severe disease, with a visual acuity range of ETDRS 20/20 to light perception. Choroidal thickness measures were determined via manual segmentation of the OCT image. Submacular choroidal thickness measurements were obtained beneath the fovea and at 500 µm intervals for 2.0 mm nasal and temporal to the centre of the fovea. These measurements on RP patients were compared to choroidal thickness measurements from 40 controls with similar refraction and no clinical evidence of retinal or glaucomatous disease. Statistical analysis was performed to compare choroidal thickness at each location between the two groups and to correlate choroidal thickness with best‐corrected visual acuity.Results Mean ages were 47.025 years for control patients and 49.3 years for RP patients (p>0.05). Mean choroidal thickness measurements were 211.9 ± 80 µm in RP patients and 305.6 ± 89 µm in controls (p<0.0001). The thickness gradually decreased toward the peripheral retina in the RP and control patients. It was greater in the temporal field than the nasal one in both groups. All values were highly significantly lower in RP group than those of the controls (p≤0.001). Patients with poorer visual acuity or older (longer duration of disease) tended to have thinner choroidsConclusion Submacular choroidal thickness, as measured by SD–OCT EDI, is significantly reduced in patients comparing with age matched cIontrol
Illness experiences in middle‐aged adults with early‐stage knee osteoarthritis: findings from a qualitative study
Authors: Kao Mei‐Hua , Tsai Yun‐Fang 
Published: November 2013

AbstractAimTo understand the illness experiences of middle‐aged adults with early knee osteoarthritis.BackgroundKnee osteoarthritis is one of the most common causes of lower limb disability in middle‐aged adults and older people. Nurses lack understanding of the illness experiences of middle‐aged patients who were confirmed to have early knee osteoarthritis and of how they manage the disease in Taiwan.DesignA qualitative descriptive design was applied.MethodsParticipants with knee osteoarthritis, aged 40–55 years, were recruited by purposive sampling (n = 17). The data were collected through semi‐structured interviews from July–December 2010. All interview transcripts were analysed using qualitative inductive content analysis to identify key themes.FindingsIllness experiences of the seventeen participants were classified into three major themes: (i) unfamiliarity with osteoarthritis; (ii) effects on daily life; and (iii) protection and alleviation. The three main themes occurred repeatedly and affected the life experiences of the patients.ConclusionsThis study indicates that patients with osteoarthritis have insufficient knowledge related to disease process and they do not know how to cope effectively. They need healthcare providers to supply them with adequate osteoarthritis disease information. Nurses should also develop interventions in their practices and guide patients to use suitable techniques to improve the functional status of their knee joint(s).
Proton pump inhibitors as a possible cause of vitiligo: an in vivo and in vitro study
Authors: Shin J.M. , Lee J.Y. , Lee D.Y. , Yoon T.Y. , Lee J.C. , Lim E.H. , Sohn K.C. , Lee Y.H. , Im M. , Seo Y.J. , Kim C.D. , Lee J.H. , Lee Y. 
Published: November 2013

AbstractBackgroundVitiligo is an acquired depigmentation disorder of melanocytes. Recently, some clinical reports have suggested that proton pump inhibitors (PPIs) may worsen vitiligo, but their effects on melanocytes have yet to be elucidated.ObjectiveWe investigated the effect of PPIs on melanogenesis in vivo and in vitro.MethodsWe examined the effect of PPIs on melanogenesis in B16 murine melanoma cells by measuring melanin content and tyrosinase (TYR) activity. TYR and tyrosinase‐related protein‐1 (TRP‐1) were monitored by western blotting. Finally, a PPI was applied to zebrafish embryos to investigate its in vivo effect on pigmentation.ResultsIn agreement with our clinical experience of worsened vitiligo after PPI treatment, PPIs decreased both melanin content and TYR activity. Western blotting showed that PPIs decreased TYR and TRP‐1 protein levels. In the zebrafish test, PPIs inhibited body pigmentation in a dose‐dependent manner.ConclusionThese results suggest that the functional inhibition of melanization by PPIs may induce or aggravate vitiligo lesions in genetically predisposed patients.
Healthcare cost impact of biological drugs compared with traditional systemic treatments in psoriasis: a cohort analysis in the French insurance database
Authors: Le Moigne M. , Sommet A. , Lapeyre‐Mestre M. , Bourrel R. , Molinier L. , Paul C. , Montastruc J‐.L. 
Published: November 2013

AbstractBackgroundBiological drugs have dramatically improved the management of moderate to severe psoriasis. Little is known about their economic impact in daily clinical practice.ObjectiveThe aim of this study was to estimate the costs of biological drugs, in term of health resources consumption, and to compare it with costs induced by traditional systemic treatments.MethodsThis cohort study was built from the French health insurance database in the Midi Pyrénées area (2.8 million inhabitants, South West of France). We compared health care costs between ‘exposed’ patients treated with biological drugs (adalimumab, etanercept, infliximab or ustekinumab) and ‘unexposed’ patients defined as patients who received traditional systemic treatments (phototherapy, acitretin, methotrexate or cyclosporin) during a 6‐month period.ResultsA total of 1924 patients met the inclusion criteria. Sixty‐nine patients were ‘exposed’, whereas 1855 patients were ‘unexposed’. ‘Exposed’ patients had a mean total healthcare cost of 8107€ vs. 1678€ (P < 0.001) for ‘unexposed’ patients. They had higher costs concerning inpatient admission, medication and consultations including dermatology consultations, laboratory, non‐medical care and transportation. Biological drug prescription was associated with an increase in the use of anti‐infective drugs and with a reduction in the use of psychoactive drugs.ConclusionThe mean total health care expenditure in patients treated with biological drugs was five times higher as compared with patients treated with traditional systemic treatments. The limitation of the study is the short duration of follow‐up comprising a loading dose period for some biological drugs. This may have contributed to an overestimation of drug‐related costs.
Ratios of regulatory T cells/T‐helper 17 cells and transforming growth factor‐β1/interleukin‐17 to be associated with the development of hepatitis B virus‐associated liver cirrhosis
Authors: Yu Xueping , Guo Ruyi , Ming Desong , Su Milong , Lin Chengzu , Deng Yong , Lin Zhenzhong , Su Zhijun 
Published: November 2013

AbstractBackground and AimThe aim of this study is to evaluate the association of the regulatory T cells (Treg)/T‐helper (Th) 17 cells and transforming growth factor‐β1 (TGF‐β1)/interleukin‐17 (IL‐17) ratios with the survival and disease progression in patients with hepatitis B virus (HBV)‐associated liver cirrhosis (LC).MethodsThe frequencies of Treg and Th17 cells were analyzed in 28 patients with HBV‐LC, 70 patients with chronic hepatitis B (CHB) and 20 normal controls (NC) by flow cytometry. The levels of cytokines related to Treg/Th17 differentiation, including IL‐10, TGF‐β1, IL‐17, and IL‐23, were measured by ELISA.ResultsCompared with NC, Treg cells were significantly increased in CHB patients and slightly increased in HBV‐LC patients, whereas Th17 cells were markedly increased both in patients with CHB and HBV‐LC. HBV‐LC patients, especially the nonsurvival ones, manifested a profound decrease in the Treg/Th17 ratio, which was negatively correlated with Child‐Pugh and model of end‐stage liver disease scores. Serum IL‐10, TGF‐β1, IL‐17, and IL‐23 levels were all significantly higher in HBV‐LC patients than in NC. In addition, the TGF‐β1/IL‐17 ratio was also markedly increased in patients with HBV‐LC, especially in nonsurvival and decompensated liver cirrhosis patients, and positively correlated with total bilirubin, Child‐Pugh, and model of end‐stage liver disease scores.ConclusionsThe decreased Treg/Th17 ratio and increased TGF‐β1/IL‐17 ratio may be associated with the survival and disease progression in HBV‐LC patients, and both of the two ratios can be used independently to predict the prognosis and disease progression of HBV‐LC patients.
Predictors of quality of life in patients with heart failure
Authors: Hwang Shiow‐Li , Liao Wen‐Chun , Huang Tsuey‐Yuan 
Published: November 2013

AbstractAimTo understand quality of life (QOL) and the effects of sociodemographics, disease severity, physical symptoms (dyspnea and fatigue), and depression on QOL of heart failure (HF) patients in Taiwan.MethodsAdult HF patients with history of cerebral vascular accident, myocardial infarction within the previous 6 months, major diseases, concurrent cancers, and coexisting terminal diseases, cognitive impairments, or residence in institutions, were excluded in this study. Quality of life, physical symptoms, and depression were measured by the Minnesota Living with Heart Failure Questionnaire, Pulmonary Function Status and Dyspnea Questionnaire, and Brief Symptom Inventory depression subscale, respectively. Hierarchical regression analyses were used to examine the correlations of demographics, disease severity, physical symptoms, and depression with QOL in HF patients.ResultsOne hundred and thirty‐three HF patients (64.2 ± 12.7 years, 78.2% male, 36.1% NYHA III/IV) were recruited in the study. In the final regression model, age, duration of HF, physical symptoms, and depression had a significant impact on global QOL, ultimately accounting for 37.6% of the variance of QOL.ConclusionAge, duration of HF, physical symptoms, and depression are important predictors of QOL in HF patients. Interventions targeting physical symptoms and depression are expected to improve QOL of HF patients.