bluuebunny/crossref_metadata_2025_split huggingface dataset:
Parental Quality of Life: Caring for an Infant or Toddler with a Tracheostomy at Home
Authors: Joseph Rachel A. , Goodfellow Linda M. , Simko Lynn M. 
Published: March 2014

Purpose:To explore the relationships between stress, coping, duration of tracheostomy, and quality of life (QOL) of parental caregivers who care for a child with a tracheostomy at home.Design:A cross-sectional correlational design was used to study parents who care for a child with a tracheostomy at home. Family Inventory of Life Events, Family Crisis Oriented Personal Evaluation Scale, and Psychological General Well-Being Index were used to measure stress, coping, and QOL, respectively. Data were collected using both online and paper-pencil format.Main Outcome Variable:quality of life.Results:Parents who care for their infants/toddlers with a tracheostomy at home were found to be in moderate distress. Mean age of the participants was 33 years (N = 71), and the average duration of the child’s tracheotomy was 18.22 (SD= 9.59) months. Multivariate analysis showed a significant inverse relationship between QOL and stress. QOL was significantly associated with coping,B= 19.91, β = .43,p<.001.
Late Norian (Late Triassic) Radiolarian assemblages from chert pebbles of the Pentalofos Formation (Mesohellenic basin, Greece). Palaeogeographic implications
Authors: Bragin Nikita , Danelian Taniel , Chanier Frank 
Published: March 2014

Abstract
Well-preserved Late Norian Radiolaria were extracted from two pebbles of radiolarian chert included in Lower Miocene conglomerates of the Pentalofos Formation, in the area of Meteora (Mesohellenic basin, Greece). Both samples yielded a similar assemblage characterized by the presence of species Betraccium deweveri PESSAGNO & BLOME, Bipedis acrostylus BRAGIN, Pylostephanidium ankaraense BRAGIN & TEKIN and several other taxa typical of the Betraccium deweveri zone (uppermost Norian). This is the first evidence of Upper Norian radiolarian cherts from Greece. It is likely that the studied chert pebbles were derived from ophiolitic complexes or distal continental margin series situated to the east of the Mesohellenic basin; they were part of the Upper Norian oceanic realm that was obducted, during the Late Jurassic, over the Pelagonian continental crust. During the Late Miocene they were still present east of Meteora and they have been eroded since.
Podiform chromitites in lherzolitic mantle rocks (Andaman ophiolite, India): the role of magma/rock interaction and parental melt composition
Authors: Ghosh Biswajit , Bhatta Koyel 
Published: March 2014

Abstract
In this study, Alpine-type (ophiolite hosted) podiform chromitites from the lherzolite dominant mantle sequence of the Andaman ophiolite, India are described. The mantle host rocks for the chromitite pods show features of melt-mantle interaction. The chromites of the podiform chromitites have high-Cr# (= Cr/[Cr + Al] atomic ratio) ranging between 0.69 and 0.75 and high-Mg# (= Mg/[Mg + Fe2+] atomic ratio) ranging between 0.58 and 0.72. Geochemically, the chromites of these high-Cr chromitites have an arc-spinel trend and suggest a supra-subduction zone setting. Contrarily, the low-Cr chromitites (reported elsewhere) show MORB-spinel trend. Parent melt composition is assessed on the basis of liquidus chromite compositions using various methods. The deduced composition shows that the melt parental to the high-Cr chromitite of the Andaman ophiolite had 12–13 wt.% Al2O3 and 0.2–0.5 wt.% TiO2 whereas the same for the low-Cr chromitites had ~ 16 wt.% Al2O3 and 0.5–0.9 wt.% TiO2. A correlation of the deduced parent melt compositions with the volcanic rocks of the Andaman ophiolite suggests a close affinity with the East Coast volcanics (south-Andaman) for the high-Cr chromitites. Contrarily, a similar correlation for the low-Cr chromitites is not so certain.
Felsic magmatism and uranium deposits
Authors: Cuney Michel 
Published: March 2014

Abstract
The strongly incompatible behaviour of uranium in silicate magmas results in its concentration in the most felsic melts and a prevalence of granites and rhyolites as primary U sources for the formation of U deposits. Despite its incompatible behavior, U deposits resulting directly from magmatic processes are quite rare. In most deposits, U is mobilized by hydrothermal fluids or ground water well after the emplacement of the igneous rocks. Of the broad range of granite types, only a few have U contents and physico-chemical properties that permit the crystallization of accessory minerals from which uranium can be leached for the formation of U deposits. The first granites on Earth, which crystallized uraninite, dated at 3.1 Ga, are the potassic granites from the Kaapval craton (South Africa) which were also the source of the detrital uraninite for the Dominion Reef and Witwatersrand quartz pebble conglomerate deposits. Four types of granites or rhyolites can be sufficiently enriched in U to represent a significant source for the genesis of U deposits: peralkaline, high-K metaluminous calc-alkaline, L-type peraluminous and anatectic pegmatoids. L-type peraluminous plutonic rocks in which U is dominantly hosted in uraninite or in the glass of their volcanic equivalents represent the best U source. Peralkaline granites or syenites are associated with the only magmatic U-deposits formed by extreme fractional crystallization. The refractory character of the U-bearing minerals does not permit their extraction under the present economic conditions and make them unfavorable U sources for other deposit types. By contrast, felsic peralkaline volcanic rocks, in which U is dominantly hosted in the glassy matrix, represent an excellent source for many deposit types. High-K calc-alkaline plutonic rocks only represent a significant U source when the U-bearing accessory minerals (U-thorite, allanite, Nb oxides) become metamict. The volcanic rocks of the same geochemistry may be also a favorable uranium source if a large part of the U is hosted in the glassy matrix. The largest U deposit in the world, Olympic Dam in South Australia is hosted by highly fractionated high-K plutonic and volcanic rocks, but the origin of the U mineralization is still unclear. Anatectic pegmatoids containing disseminated uraninite which results from the partial melting of uranium-rich metasediments and/or metavolcanic felsic rocks, host large low grade U deposits such as the Rössing and Husab deposits in Namibia.
The evaluation of the potentiality for igneous rocks to represent an efficient U source represents a critical step to consider during the early stages of exploration for most U deposit types. In particular a wider use of the magmatic inclusions to determine the parent magma chemistry and its U content is of utmost interest to evaluate the U source potential of sedimentary basins that contain felsic volcanic acidic tuffs.
Deciphering orogeny: a metamorphic perspective. Examples from European Alpine and Variscan belts
Authors: Lardeaux Jean-Marc 
Published: March 2014

AbstractIn this paper we review and discuss, in a synthetic historical way, the main results obtained on Alpine metamorphism in the western Alps. First, we describe the finite metamorphic architecture of the western Alps and discuss its relationships with subduction and collision processes. Second, we portray the progressive metamorphic evolution through time and space with the presentation of 5 metamorphic maps corresponding to critical orogenic periods, namely 85-65 Ma, 60-50 Ma, 48-40 Ma, 38-33 Ma and 30-20 Ma. We underline the lack of temporal data on high-pressure/low-temperature metamorphic rocks as well as the severe uncertainties on the sizes of rock units that have recorded the same metamorphic history (i.e. coherent P-T-t/deformation trajectories). We discuss the role of subduction-driven metamorphism in ocean-derived protoliths and the conflicting models that account for the diachrony of continental subductions in the western Alps.
A Retrospective Analysis of Isoniazid-Monoresistant Tuberculosis: Among Iranian Pulmonary Tuberculosis Patients
Authors: Varahram Mohammad , Nasiri Mohammad Javad , Farnia Parissa , Mozafari Mohadese , Velayati Ali Akbar 
Published: March 2014

Background and objectives:Isoniazid (INH) is one of the most potent anti-tuberculosis (TB) drugs. The spread and transmission of INH- resistant bacilli are likely to pose a significant problem for National TB control Program (NTP). In this study, we aimed to determine the trend of INH-monoresistant TB in Iran.Methods:The susceptibility patternsof Mycobacterium tuberculosis(MTB) strains that were isolated from clinical samples were retrospectively analyzed (January 2003-December 2011). Identification and drug susceptibility testing (DST) were performed using both conventional and molecular methods. The associated risk factors were assessed using the Chi-square test.Results:Out of 4825 culture-positive isolates, 6.1% were resistant to INH, with an increasing trend over the study period. The INH-monoresistance from 4.4 in 2003 reached to 9.4% in 2011. Among the studied risk factors, age was significantly associated with INH-monoresistance (p < 0.05).Conclusions:The increased trend in INH-monoresistance underlines the need for greater enforcement of national TB control programs. In this regard, better management of TB cases, establishing advanced diagnostic facilities and use of standard treatment regimens are recommended to avoid further emergence of INH resistant cases.
The Effect of Molecular Parameters on the Thermal Behavior of Recycled and Virgin Polyamides and Their Glass Fiber Composites
Authors: Mirzadeh A. , Ghasemi H. , Bates P. J. , Kamal M. R. 
Published: March 2014

Abstract
A study was carried out to evaluate the effects of molecular weight and molecular structure on non-isothermal crystallization behavior of recycled and virgin polyamides (PA) and their corresponding glass fiber (GF) composites. Two different recycled polyamides (PA), namely post-industrial waste (PIW) and post-consumer waste (PCW) were used. The former was obtained from a fiber manufacturer and the latter was recycled from used carpets. The molecular weights of the resins were measured by intrinsic viscosity (IV) measurements and 13carbon nuclear magnetic resonance (13C-NMR). The NMR technique also provided information on PA structure, cis and trans amide conformers content and residual unreacted monomer. Non-isothermal crystallization of the resins was studied using differential scanning calorimetry (DSC). The molecular weights of recycled materials were higher than that of virgin injection molding grade PA-6. However, the crystallization rates (indicated by t1/2) of recycled resins were faster. It could be attributed to the presence of TiO2 in recycled materials. Moreover, the higher cis-amide conformer content of recycled resins suggested higher segmental mobility. On the other hand, the crystallization rate of composites based on recycled PA-6 was slower than that of composites based on the virgin PA-6. The suppression of crystallization rate was apparently due to PA-66 added during the preparation of reinforced recycled resins. This behavior was confirmed by model compounds based on PA-6/PA-66 blends.
Carbon Nanotube Conductive Networks through the Double Percolation Concept in Polymer Systems
Authors: Abbasi S. , Derdouri A. , Carreau P. J. 
Published: March 2014

Abstract
We investigated the electrical conductivity and percolation behavior of binary and ternary nanocomposites based on multiwalled carbon nanotubes (MWCNs) using polypropylene (PP) and a blend of PP with cyclic butylene terephthalate (CBT). The nanocomposites were prepared by diluting a commercial 20 %wtMWCNT PP masterbatch using optimized melt-mixing conditions. The concentration of carbon nanotubes in the diluted PP samples was as low as 0.5 % and as high as 15 % in weight. For the PP/CBT blend CBT concentration was varied up to 40 %wt while the loading of CNT was from 0 to 5 %wt. SEM and TEM techniques were used to examine the quality of the dispersion and the formation of nanotube networks within the polymer matrix. TEM and Raman spectroscopy results showed that for the diluted PP/MWCNT composites the nanotubes are well aligned in samples obtained the microinjection molding process, although the level of alignment is less with crystalline PP than in an amorphous matrix such as polycarbonate (PC). FTIR and XRD results revealed that the orientation of both polymer chains and crystals decreased with the incorporation of nanotubes into PP. The electrical conductivity was also significantly altered by the nanotube alignment in a PP matrix, as was previously observed for PC/MWCNT composites; the conductivity decreased and the percolation threshold rose in highly sheared samples; however, the presence of a crystalline phase improved the conductivity even for high shear conditions through the phenomenon of double percolation threshold. This last concept refers to the requirement that the filler-rich phase be continuous and conductive and not to the existence of two percolation thresholds at two different CNT concentrations. The electrical conductivity of PP/CBT blends was also improved through a double percolation that is the basic requirement for the conductivity of the ternary nanocomposites.
Influence of Solvent Washing and Soxhlet Extraction on the Thermal Stability of Organically Modified Layered Silicates
Authors: Mariappan T. , Wilkie C. A. 
Published: March 2014

Abstract
An efficacious process for removing excess surfactant and sodium halide from an organically-modified clay is described in this paper. Improved thermal stability of the organoclay is observed using both washing with ethanol or Soxhlet extraction with methanol. The selection of the solvent to be used plays a vital role in removing the excess organic modifier from the organoclay. Approximately a 60 °C increment in onset thermal stability (T5%) is observed by solvent washing while a further 20 °C improvement is seen using Soxhlet extraction. Washing with hot deionized water followed by an ethanol washing will remove the excess modifier more effectively than does hot DI water and THF.
Effect of Screw Rotation Speed on the Properties of Polycarbonate/Vapor-Grown Carbon Fiber Composites Prepared by Melt Compounding
Authors: Tanoue S. , Nithikaranjanatharn J. , Okuzono H. , Ueda H. , Uematsu H. , Iemoto Y. 
Published: March 2014

Abstract
The effect of screw rotation speed on the mechanical property and thermal conductivity of polycarbonate (PC)/vapor-grown carbon fiber (VGCF) composites prepared by a twin screw extruder was discussed in this paper. Two types of VGCF (VGCF-H, the aspect ratio of 40, and VGCF-S, the aspect ratio of 100) were used. In the tensile test, the breaking pattern of PC composite changed to brittle failures by adding VGCF-H irrespective of screw rotation speed. Young's modulus of PC/VGCF-H slightly increased with the screw rotation speed. On the other hands, the breaking strain of PC/VGCF drastically decreased above 150 min−1. Young's modulus of PC/VGCF-S slightly increased with screw rotation speed until 150 min−1, however, it decreased at 175 min−1. The thermal conductivity of PC/VGCF-H was independent of the screw rotation speed. In contrast, the thermal conductivity of PC/VGCF-S gradually increased with screw rotation speed until 150 min−1 and it also decreased at 175 min−1. From the SEM observation and rheological behavior, the dispersion state of VGCF-H in PC/VGCF-H was independent of the screw rotation speed. On the other hands, the network structures of VGCF-S were observed in PC/VGCF-S and the state of these network structures depended on the screw rotation speed. It was clarified that the mechanical property and thermal conductivity of PC/VGCF were attributable to the dispersion state of VGCF.
Effects of Polymer Viscosity and Nanofillers on Morphology of Nanofibers Obtained by a Gas Jet Method
Authors: Shang J.-H. , Benavides R. E. , Jana S. C. 
Published: March 2014

Abstract
This research evaluates the effects of molecular weight, polymer solution concentration, and carbon nanotube concentration on diameter distribution of polymer nanofibers produced with gas jet fiber (GJF) method. In GJF method, the shear and extensional forces of high-velocity gas jets are used to spin fibers from polymer solutions. The correlation between polymer molecular weight and fiber diameter distribution is studied along with the effect of multi-walled carbon nanotubes (MWCNT) on fiber diameter distribution. The paper also assesses how carbon nanotubes distribute in bi-component polymer nanofibers. It is found that polymer chain entanglement is a key determinant of fiber diameter. MWCNTs do not show preference for distribution in polyvinylidene pyrrole (PVP) and polyvinylacetate (PVAc) and instead appear on the surfaces of the fibers. A negative value of spreading coefficient supports this observation.
Modeling of the Torque Requirements for the Mixing and Dispersion of Silica into Rubber
Authors: Law Y. Y. , Feke D. L. , Manas-Zloczower I. 
Published: March 2014

Abstract
A model for the evolution of torque requirements in the batch mixing of silica agglomerates in styrene-butadiene rubber has been developed. The analysis considers the rheology of suspensions as modeled by the Krieger-Dougherty equation but with modifications so that it can apply to a wider range of solids loading, and combines that with a separate model that expresses the kinetics of the dispersion of silica agglomerates. The model shows good agreement with the trends of experimental data, and thus can be used to make predictions about torque requirements for compounding commercial grades of silica into rubber, as related to dispersion, under practical mixing conditions.
IκBε Is a Key Regulator of B Cell Expansion by Providing Negative Feedback on cRel and RelA in a Stimulus-Specific Manner
Authors: Alves Bryce N. , Tsui Rachel , Almaden Jonathan , Shokhirev Maxim N. , Davis-Turak Jeremy , Fujimoto Jessica , Birnbaum Harry , Ponomarenko Julia , Hoffmann Alexander 
Published: March 2014

Abstract
The transcription factor NF-κB is a regulator of inflammatory and adaptive immune responses, yet only IκBα was shown to limit NF-κB activation and inflammatory responses. We investigated another negative feedback regulator, IκBε, in the regulation of B cell proliferation and survival. Loss of IκBε resulted in increased B cell proliferation and survival in response to both antigenic and innate stimulation. NF-κB activity was elevated during late-phase activation, but the dimer composition was stimulus specific. In response to IgM, cRel dimers were elevated in IκBε-deficient cells, yet in response to LPS, RelA dimers also were elevated. The corresponding dimer-specific sequences were found in the promoters of hyperactivated genes. Using a mathematical model of the NF-κB–signaling system in B cells, we demonstrated that kinetic considerations of IκB kinase–signaling input and IκBε’s interactions with RelA- and cRel-specific dimers could account for this stimulus specificity. cRel is known to be the key regulator of B cell expansion. We found that the RelA-specific phenotype in LPS-stimulated cells was physiologically relevant: unbiased transcriptome profiling revealed that the inflammatory cytokine IL-6 was hyperactivated in IκBε−/− B cells. When IL-6R was blocked, LPS-responsive IκBε−/− B cell proliferation was reduced to near wild-type levels. Our results provide novel evidence for a critical role for immune-response functions of IκBε in B cells; it regulates proliferative capacity via at least two mechanisms involving cRel- and RelA-containing NF-κB dimers. This study illustrates the importance of kinetic considerations in understanding the functional specificity of negative-feedback regulators.
Enhanced Antibody Responses to an HIV-1 Membrane-Proximal External Region Antigen in Mice Reconstituted with Cultured Lymphocytes
Authors: Holl T. Matt , Yang Guang , Kuraoka Masayuki , Verkoczy Laurent , Alam S. Munir , Moody M. Anthony , Haynes Barton F. , Kelsoe Garnett 
Published: March 2014

Abstract
We have shown that the protective HIV-1 Ab, 2F5, avidly reacts with a conserved mammalian self-Ag, kynureninase, and that the development of B cells specific for the 2F5 epitope is constrained by immunological tolerance. These observations suggest that the capacity to mount Ab responses to the 2F5 epitope is mitigated by tolerance, but such capacity may be latent in the pretolerance and/or anergic B cell pools. In this study, we use B cell tetramer reagents to track the frequencies of B cells that recognize the HIV-1 2F5 epitope (SP62): in C57BL/6 mice, SP62-binding transitional B cells are readily identified in bone marrow but are lost during subsequent development. Unsurprisingly then, immunization with SP62 immunogen does not elicit significant humoral responses in normal C57BL/6 mice. Reconstitution of Rag1null mice with normal congenic B cells that have matured in vitro restores the capacity to mount significant serum Ab and germinal center responses to this HIV-1 epitope. These B cell cultures are permissive for the development of autoreactive B cells and support the development of SP62-specific B cell compartments normally lost in 2F5 Ab knockin mice. The recovery of humoral responses to the 2F5/SP62 epitope of HIV-1 by reconstitution with B cells containing forbidden, autoreactive clones provides direct evidence that normal C57BL/6 mice latently possess the capacity to generate humoral responses to a conserved, neutralizing HIV-1 epitope.
Xenograft Tolerance and Immune Function of Human T Cells Developing in Pig Thymus Xenografts
Authors: Kalscheuer Hannes , Onoe Takashi , Dahmani Alexander , Li Hao-Wei , Hölzl Markus , Yamada Kazuhiko , Sykes Megan 
Published: March 2014

Abstract
Transplantation of xenogeneic thymus tissue allows xenograft tolerance induction in the highly disparate pig-to-mouse model. Fetal swine thymus (SW THY) can support the generation of a diverse human T cell repertoire that is tolerant of the pig in vitro. We demonstrate that SW THY generates all human T cell subsets, including regulatory T cells (Tregs), in similar numbers as fetal human thymus (HU THY) grafts in immunodeficient mice receiving the same human CD34+ cells. Peripheral T cells are specifically tolerant to the mouse and to the human and porcine donors, with robust responses to nondonor human and pig Ags. Specific tolerance is observed to pig skin grafts sharing the THY donor MHC. SW THY–generated peripheral Tregs show similar function, but include lower percentages of naive-type Tregs compared with HU THY–generated Tregs. Tregs contribute to donor-pig specific tolerance. Peripheral human T cells generated in SW THY exhibit reduced proportions of CD8+ T cells and reduced lymphopenia-driven proliferation and memory-type conversion, accelerated decay of memory-type cells, and reduced responses to protein Ags. Thus, SW thymus transplantation is a powerful xenotolerance approach for human T cells. However, immune function may be further enhanced by strategies to permit positive selection by autologous HLA molecules.