bluuebunny/crossref_metadata_2025_split huggingface dataset:
Memory reconsolidation keeps track of emotional changes, but what will explain the actual “processing”?
Authors: Pascual-Leone Antonio , Pascual-Leone Juan 
Published: June 2015

AbstractWe question memory reconsolidation and emotional arousal as sufficient determinants of therapeutic change. Generating new feelings and meanings must be contrasted with activating and stabilizing the evolving memories that reflect those novel experiences. Some therapeutic changes are not attributable to a memory model alone. “Emotional processing” is also needed and is often an undeclared form of complex executive problem solving.
The trans-riverine genetic structure of 28 Amazonian frog species is dependent on life history
Authors: Fouquet Antoine , Courtois Elodie A. , Baudain Daniel , Lima Jucivaldo Dias , Souza Sergio Marques , Noonan Brice P. , Rodrigues Miguel T. 
Published: June 2015

Abstract:Among the hypotheses formulated to explain the origin of Amazonian biodiversity, two (the riverine-barrier and the river-refuge hypotheses) focus on the role that rivers play as biotic barriers promoting speciation. However, empirical results have both supported and refuted these hypotheses. This is likely due, at least in part, to river-specific hydrologic characteristics and the biology of the focal species. The rivers of the Guiana Shield represent a model system because they have had more stable courses over time than those of the western Amazon Basin, where most tests of riverine barrier effects have taken place. We tested whether life-history traits (body size, habitat and larval development), expected to be important in determining dispersal ability, of 28 frog species are associated with genetic structure and genetic distances of individuals sampled from both banks of the Oyapock River. Thirteen of these species displayed genetic structure consistent with the river acting as a barrier to dispersal. Surprisingly, body size was not correlated with trans-riverine population structure. However, leaf-litter dwellers and species lacking free-living tadpoles were found to exhibit higher river-associated structure than open habitat/arboreal species and those with exotrophic tadpoles. These results demonstrate that rivers play an important role in structuring the genetic diversity of many frog species though the permeability of such riverine barriers is highly dependent on species-specific traits.
Fruit colour conceals endocarp dimorphism from avian seed dispersers in a tropical beach plant,Scaevola taccada(Goodeniaceae), found in Okinawa
Authors: Tanaka Keita D. , Denda Tetsuo , Ueda Keisuke , Emura Naoko 
Published: June 2015

Abstract:Theory predicts that honest signalling strategies will not always be evolutionarily stable in interspecific communication, yet to demonstrate such a transition of signalling modality between honesty and dishonesty in the wild would be difficult. An endocarp dimorphism has been found inScaevola taccadafruits: a morph with a cork substrate that facilitates ocean current seed dispersal and a morph without the cork. Both types of fruit are covered with sugar-containing flesh, and are similar in size and colour to one another (at least from a human perspective). The apparent lack of external differences between morphotypes could potentially degrade mutualistic relations between the plant and seed-dispersing birds because the presence of a cork could lower the fruit's nutritional value. Thus, unless seed dispersers can discriminate between the different types of fruit, this system may provide an example of a transition between honest and dishonest signalling. We examinedS. taccadafruit and leaf colours from an avian visual perspective. Even though the fruits and leaves were different in colour from one another to birds, there was no perceivable difference in the colours between fruit morphotypes. Therefore, fruit colour is not an honest indicator of reward to seed dispersers. Further, we propose an adoption of a statistical method in avian visual modelling studies that avoids the common statistical errors, such as violation of the congruence principle.
The Impact of External Change on Civil Service Values in Post-Colonial Hong Kong
Authors: Burns John P. , Wei Li 
Published: June 2015

AbstractScholarly work in the 1990s indicated that the values of civil servants in late colonial Hong Kong were evolving from those of classical bureaucrats to those of more political bureaucrats as the political and social environment changed. Based on in-depth interviews with 58 politicians and senior civil servants carried out between 2009 and 2012, we argue that Hong Kong civil service values have adapted owing in part to external shocks such as regime change and governance reform. Still, traditional civil service values such as fiscal prudence and balancing various community interests continue to be prominent. We illustrate the influence of civil service values in two policymaking cases: small-class teaching and minimum-wage legislation.
The Political Geography of Nationalist Protest in China: Cities and the 2012 Anti-Japanese Protests
Authors: Wallace Jeremy L. , Weiss Jessica Chen 
Published: June 2015

AbstractWhy do some Chinese cities take part in waves of nationalist protest but not others? Nationalist protest remains an important but understudied topic within the study of contentious politics in China, particularly at the subnational level. Relative to other protests, nationalist mobilization is more clustered in time and geographically widespread, uniting citizens in different cities against a common target. Although the literature has debated the degree of state-led and grassroots influence on Chinese nationalism, we argue that it is important to consider both the propensity of citizens to mobilize and local government fears of instability. Analysing an original dataset of 377 anti-Japanese protests across 208 of 287 Chinese prefectural cities, we find that both state-led patriotism and the availability of collective action resources were positively associated with nationalist protest, particularly “biographically available” populations of students and migrants. In addition, the government's role was not monolithically facilitative. Fears of social unrest shaped the local political opportunity structure, with anti-Japanese protests less likely in cities with larger populations of unemployed college graduates and ethnic minorities and more likely in cities with established leaders.
The making of the central markets of Dakar and Kinshasa: from colonial origins to the post-colonial period
Authors: BEECKMANS LUCE , BIGON LIORA 
Published: June 2015

ABSTRACTThis article traces the planning history of two central marketplaces in sub-Saharan Africa, in Dakar and Kinshasa, from their French and Belgian colonial origins until the post-colonial period. In the (post-)colonial city, the marketplace has always been at the centre of contemporary debates on urban identity and spatial production. Using a rich variety of sources, this article makes a contribution to a neglected area of scholarship, as comparative studies on planning histories in sub-Saharan African cities are still rare. It also touches upon some key issues such as the multiple and often intricate processes of urban agency between local and foreign actors, sanitation and segregation, the different (post-)colonial planning cultures and their limits and the role of indigenous/intermediary groups in spatial contestation and reappropriation.
Barcelona food retailing and public markets, 1876–1936
Authors: FAVA NADIA , GUÀRDIA MANEL , OYÓN JOSÉ LUIS 
Published: June 2015

ABSTRACTThis article is a contribution to comparative research between specific urban markets trajectories in the nineteenth and twentieth centuries and it aims to juxtapose southern European food market experiences, particularly the Barcelona case, with west European ones. Like other big cities in southern and central Europe, Barcelona consolidated a sturdy polycentric system of district markets between 1876 and 1936, just when such markets were beginning to decline in ‘first comers’ cities of Britain and France. In the inter-war period, the market halls of southern European cities played a prominent role in the everyday food trade and as functional and socializing centres in neighbourhoods. They were poles of dense residential and kinship relations for stall vendors, especially women vendors, and foci of a large part of the food retailing business in many neighbourhoods. Barcelona's particular historical circumstances made the public covered market system a fundamental element of neighbourhood commerce and a long-term urban asset.
HoBi-like viruses – the typical ‘atypical bovine pestivirus’
Authors: Bauermann Fernando V. , Ridpath Julia F. 
Published: June 2015

AbstractHoBi-like viruses, also referred to as bovine viral diarrhea virus 3 (BVDV-3) and atypical pestivirus, have been proposed as a new putative bovine pestivirus species. These viruses were first identified in the last decade and are currently distributed in at least three continents. Published findings suggest that these viruses may be endemic at least in parts of South America and Asia. The clinical presentations in cattle, described in field outbreaks and controlled studies, are similar to those associated with BVDV and range from subclinical to mild clinical signs, sporadically associated with reproductive losses, respiratory illness and hemorrhagic syndrome. The complete host range of HoBi-like virus is unknown, but data suggest higher adaptation of HoBi-like viruses to ruminants than swine. Acute infections, characterized by mild clinical signs, such as low-grade pyrexia and leukopenia, have been observed in both cattle and sheep. Virus has been isolated from nasal swabs indicating that virus was being shed. While seroconversion has been observed in pigs, no clinical presentation or viral shedding was evident following inoculation. While some commercial BVDV diagnostic tests may detect HoBi-like viruses, these tests do not differentiate between BVDV and HoBi-like viruses. The differentiation of BVDV and HoBi-like viruses is critical to the design of surveillance programs for these viruses.
Pestivirus control programs: how far have we come and where are we going?
Authors: Moennig Volker , Becher Paul 
Published: June 2015

AbstractClassical swine fever (CSF) is endemic in large parts of the world and it is a major threat to the pig industry in general. Vaccination and stamping out have been the most successful tools for the control and elimination of the disease. The systematic use of modified live vaccines (MLV), which are very efficacious and safe, has often preceded the elimination of CSF from regions or countries. Oral vaccination using MLV is a powerful tool for the elimination of CSF from wild boar populations. Bovine virus diarrhea (BVD) is endemic in bovine populations worldwide and programs for its control are only slowly gaining ground. With two genotypes BVD virus (BVDV) is genetically more diverse than CSF virus (CSFV). BVDV crosses the placenta of pregnant cattle resulting in the birth of persistently infected (PI) calves. PI animals shed enormous amounts of virus for the rest of their lives and they are the reservoir for the spread of BVDV in cattle populations. They are the main reason for the failure of conventional control strategies based on vaccination only. In Europe two different approaches for the successful control of BVD are being used: Elimination of PI animals without or with the optional use of vaccines, respectively.
Pestiviruses: old enemies and new challenges
Authors: Ridpath Julia F. , Neill John D. 
Published: June 2015

AbstractThe genesis for this special issue on pestiviruses was a joint meeting on pestiviruses organized by the US BVDV Symposia Committee and the European Society for Veterinary Virology that was held October 14 and 15, 2014 in Kansas City, MO. The theme of the meeting was “Pestiviruses: Old enemies and new challenges”. The impetus for this joint effort was the recognition that regional approaches to disease control are at odds with the worldwide traffic in animal products and biologics. Further, the control of newly recognized pestiviruses, such as HoBi-like viruses, is more effective when approached as a global challenge rather than any one nation's problem. The joint meeting featured talks by researchers from North America, South America, Australia and Europe. The papers in this issue arose from keynote talks presented at the joint meeting and are organized around the following themes; pestiviruses and the immune system, genetic variability, the emergence of new pestiviruses and pestivirus control programs.
Chirality- and sequence-selective successive self-sorting via specific homo- and complementary-duplex formations
Authors: Makiguchi Wataru , Tanabe Junki , Yamada Hidekazu , Iida Hiroki , Taura Daisuke , Ousaka Naoki , Yashima Eiji 
Published: June 2015

AbstractSelf-recognition and self-discrimination within complex mixtures are of fundamental importance in biological systems, which entirely rely on the preprogrammed monomer sequences and homochirality of biological macromolecules. Here we report artificial chirality- and sequence-selective successive self-sorting of chiral dimeric strands bearing carboxylic acid or amidine groups joined by chiral amide linkers with different sequences through homo- and complementary-duplex formations. A mixture of carboxylic acid dimers linked by racemic-1,2-cyclohexane bis-amides with different amide sequences (NHCO or CONH) self-associate to form homoduplexes in a completely sequence-selective way, the structures of which are different from each other depending on the linker amide sequences. The further addition of an enantiopure amide-linked amidine dimer to a mixture of the racemic carboxylic acid dimers resulted in the formation of a single optically pure complementary duplex with a 100% diastereoselectivity and complete sequence specificity stabilized by the amidinium–carboxylate salt bridges, leading to the perfect chirality- and sequence-selective duplex formation.
Loss of microRNA-27b contributes to breast cancer stem cell generation by activating ENPP1
Authors: Takahashi Ryou-u , Miyazaki Hiroaki , Takeshita Fumitaka , Yamamoto Yusuke , Minoura Kaho , Ono Makiko , Kodaira Makoto , Tamura Kenji , Mori Masaki , Ochiya Takahiro 
Published: June 2015

AbstractCancer stem cells (CSCs) have been identified in various types of cancer; however, the mechanisms by which cells acquire CSC properties such as drug resistance and tumour seeding ability are not fully understood. Here, we identified microRNA-27b (miR-27b) as a key regulator for the generation of a side-population in breast cancer cells that showed CSC properties, and also found that the anti-type II diabetes (T2D) drug metformin reduced this side-population via miR-27b-mediated repression of ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1), which is involved in T2D development. ENPP1 induced the generation of the side-population via upregulation of the ABCG2 transporter. ENPP1 was also identified as a substrate of the 26S proteasome, the activity of which is downregulated in CSCs. Overall, these results demonstrate that a T2D-associated gene plays an important role in tumour development and that its expression is strictly controlled at the mRNA and protein levels.
Effective heritable gene knockdown in zebrafish using synthetic microRNAs
Authors: Giacomotto Jean , Rinkwitz Silke , Becker Thomas S. 
Published: June 2015

AbstractAlthough zebrafish is used to model human diseases through mutational and morpholino-based knockdown approaches, there are currently no robust transgenic knockdown tools. Here we investigate the knockdown efficiency of three synthetic miRNA-expressing backbones and show that these constructs can downregulate a sensor transgene with different degrees of potency. Using this approach, we reproduce spinal muscular atrophy (SMA) in zebrafish by targeting the smn1 gene. We also generate different transgenic lines, with severity and age of onset correlated to the level of smn1 inhibition, recapitulating for the first time the different forms of SMA in zebrafish. These lines are proof-of-concept that miRNA-based approaches can be used to generate potent heritable gene knockdown in zebrafish.
Kruppel-like factor 4 signals through microRNA-206 to promote tumor initiation and cell survival
Authors: Lin C-C , Sharma S B , Farrugia M K , McLaughlin S L , Ice R J , Loskutov Y V , Pugacheva E N , Brundage K M , Chen D , Ruppert J M 
Published: June 2015

AbstractTumor cell heterogeneity poses a major hurdle in the treatment of cancer. Mammary cancer stem-like cells (MaCSCs), or tumor-initiating cells, are highly tumorigenic sub-populations that have the potential to self-renew and to differentiate. These cells are clinically important, as they display therapeutic resistance and may contribute to treatment failure and recurrence, but the signaling axes relevant to the tumorigenic phenotype are poorly defined. The zinc-finger transcription factor Kruppel-like factor 4 (KLF4) is a pluripotency mediator that is enriched in MaCSCs. KLF4 promotes RAS-extracellular signal-regulated kinase pathway activity and tumor cell survival in triple-negative breast cancer (TNBC) cells. In this study, we found that both KLF4 and a downstream effector, microRNA-206 (miR-206), are selectively enriched in the MaCSC fractions of cultured human TNBC cell lines, as well as in the aldehyde dehydrogenase-high MaCSC sub-population of cells derived from xenografted human mammary carcinomas. The suppression of endogenous KLF4 or miR-206 activities abrogated cell survival and in vivo tumor initiation, despite having only subtle effects on MaCSC abundance. Using a combinatorial approach that included in silico as well as loss- and gain-of-function in vitro assays, we identified miR-206-mediated repression of the pro-apoptotic molecules programmed cell death 4 (PDCD4) and connexin 43 (CX43/GJA1). Depletion of either of these two miR-206-regulated transcripts promoted resistance to anoikis, a prominent feature of CSCs, but did not consistently alter MaCSC abundance. Consistent with increased levels of miR-206 in MaCSCs, the expression of both PDCD4 and CX43 was suppressed in these cells relative to control cells. These results identify miR-206 as an effector of KLF4-mediated prosurvival signaling in MaCSCs through repression of PDCD4 and CX43. Consequently, our study suggests that a pluripotency factor exerts prosurvival signaling in MaCSCs, and that antagonism of KLF4-miR-206 signaling may selectively target the MaCSC niche in TNBC.
Global database of paleocurrent trends through the Phanerozoic and Precambrian
Authors: Brand Leonard , Wang Mingmin , Chadwick Arthur 
Published: June 2015

AbstractPaleocurrents are sedimentological features contained in all sedimentary deposits, enabling the direction of movement of the sediment and the containing fluid at the time of deposition to be determined. This database contains paleocurrent directions and other relevant associated data from published sources and theses and dissertations for the entire Phanerozoic and Precambrian for all continents. Such information may be of general interest to sedimentologists and will be of specific interest in sedimentary basin analysis, and to petroleum geologists and mineralogists seeking source areas. Paleocurrents may also be useful in plate reconstructions and in testing the timing of global tectonic events.
Snapshot Serengeti, high-frequency annotated camera trap images of 40 mammalian species in an African savanna
Authors: Swanson Alexandra , Kosmala Margaret , Lintott Chris , Simpson Robert , Smith Arfon , Packer Craig 
Published: June 2015

AbstractCamera traps can be used to address large-scale questions in community ecology by providing systematic data on an array of wide-ranging species. We deployed 225 camera traps across 1,125 km2 in Serengeti National Park, Tanzania, to evaluate spatial and temporal inter-species dynamics. The cameras have operated continuously since 2010 and had accumulated 99,241 camera-trap days and produced 1.2 million sets of pictures by 2013. Members of the general public classified the images via the citizen-science website www.snapshotserengeti.org. Multiple users viewed each image and recorded the species, number of individuals, associated behaviours, and presence of young. Over 28,000 registered users contributed 10.8 million classifications. We applied a simple algorithm to aggregate these individual classifications into a final ‘consensus’ dataset, yielding a final classification for each image and a measure of agreement among individual answers. The consensus classifications and raw imagery provide an unparalleled opportunity to investigate multi-species dynamics in an intact ecosystem and a valuable resource for machine-learning and computer-vision research.
A daily global mesoscale ocean eddy dataset from satellite altimetry
Authors: Faghmous James H. , Frenger Ivy , Yao Yuanshun , Warmka Robert , Lindell Aron , Kumar Vipin 
Published: June 2015

AbstractMesoscale ocean eddies are ubiquitous coherent rotating structures of water with radial scales on the order of 100 kilometers. Eddies play a key role in the transport and mixing of momentum and tracers across the World Ocean. We present a global daily mesoscale ocean eddy dataset that contains ~45 million mesoscale features and 3.3 million eddy trajectories that persist at least two days as identified in the AVISO dataset over a period of 1993–2014. This dataset, along with the open-source eddy identification software, extract eddies with any parameters (minimum size, lifetime, etc.), to study global eddy properties and dynamics, and to empirically estimate the impact eddies have on mass or heat transport. Furthermore, our open-source software may be used to identify mesoscale features in model simulations and compare them to observed features. Finally, this dataset can be used to study the interaction between mesoscale ocean eddies and other components of the Earth System.
Human Embryonic Stem Cell-Derived Progenitors Assist Functional Sensory Axon Regeneration after Dorsal Root Avulsion Injury
Authors: Hoeber Jan , Trolle Carl , Konig Niclas , Du Zhongwei , Gallo Alessandro , Hermans Emmanuel , Aldskogius Hakan , Shortland Peter , Zhang Su-Chun , Deumens Ronald , Kozlova Elena N. 
Published: June 2015

AbstractDorsal root avulsion results in permanent impairment of sensory functions due to disconnection between the peripheral and central nervous system. Improved strategies are therefore needed to reconnect injured sensory neurons with their spinal cord targets in order to achieve functional repair after brachial and lumbosacral plexus avulsion injuries. Here, we show that sensory functions can be restored in the adult mouse if avulsed sensory fibers are bridged with the spinal cord by human neural progenitor (hNP) transplants. Responses to peripheral mechanical sensory stimulation were significantly improved in transplanted animals. Transganglionic tracing showed host sensory axons only in the spinal cord dorsal horn of treated animals. Immunohistochemical analysis confirmed that sensory fibers had grown through the bridge and showed robust survival and differentiation of the transplants. Section of the repaired dorsal roots distal to the transplant completely abolished the behavioral improvement. This demonstrates that hNP transplants promote recovery of sensorimotor functions after dorsal root avulsion and that these effects are mediated by spinal ingrowth of host sensory axons. These results provide a rationale for the development of novel stem cell-based strategies for functionally useful bridging of the peripheral and central nervous system.