bluuebunny/crossref_metadata_2025_split huggingface dataset:
A Delphi Consensus on Surgical Technique of Roux-en-Y Gastric Bypass: An Obesity and Metabolic Surgery Society of India Initiative
Authors: Bindal Vivek , Pandey Dhananjay , Wadhawan Randeep , Bhasker Aparna Govil , Goel Ramen Gyanendra , Kular K. S. , Shah Sumeet , Raj Praveen , Khaitan Manish , Narwaria Mahendra , Chowbey Pradeep , Dhorepatil Shrihari , Khullar Rajesh , Kumari Lashmi Kona , Peters Atul N.C. , Goel Deep , Baijal Manish , Shah Shashank , Aggarwal Sandeep , Ugale Surendra , Bhojwani Rajesh , Patolia Sanjay , Dukkipati Nandakishore , Gupta Shailesh , Ahmed Shahiq 
Published: August 2024

Abstract

Introduction:
Roux-en-Y gastric bypass (RYGB) is considered the gold standard bariatric surgical procedure. However, its complexity has led to various technical adaptations being practiced globally, including in India. Recognizing the need for uniformity in such a crucial procedure, the Obesity Surgery Society of India (OSSI) took the initiative of doing a Delphi consensus on the technique of RYGB.

Methods:
A panel of 17 experts, chosen from OSSI members, was formed based on their extensive experience with RYGB, years of practice, the proportion of RYGB in their practice, and their academic contributions and recommendations from the executive committee. A questionnaire comprising 40 statements regarding the key steps of the procedure was shared with the selected experts through email. Consensus was deemed to be reached when the statements received scores exceeding 70%.

Results:
After three rounds of surveys, consensus was reached on 34 statements. Following the first round, statements without consensus underwent reformulation and were redistributed along with pertinent literature. Despite these efforts, six statements remained unresolved by the end of the third round, indicating areas where expert consensus could not be achieved.

Conclusions:
This Delphi consensus gives a snapshot in the practices of experts doing RYGB in India. It details the various intricacies and technical aspects of the procedure.
Effectiveness of anterior repositioning splint versus other occlusal splints in the management of temporomandibular joint disc displacement with reduction: A meta-analysis
Authors: Maheshwari Komal , Srinivasan Ramya , Singh Balendra Pratap , Tiwari Bhawana , Kirubakaran Richard 
Published: August 2024

Background:
Disc displacement with reduction (DDwR) is among the common disc disorders of temporomandibular joint (TMJ), which can be managed conservatively by splint therapy. Anterior repositioning splint (ARS) is the most commonly prescribed splint by dental practitioners, but not getting a normal disc–condyle relationship always and other side effects lead to need of comparing with other occlusal splints. This review will help in informed decision-making by clinicians in choosing an appropriate splint type for patients.

Aim:
The aim is to compare the effectiveness of ARS in the management of DDwR with other occlusal splints for TMJ and muscle pain, TMJ noise, any adverse effects, regaining normal disc–condyle relationship.

Materials and Methods:
We followed published protocol in the International prospective register of systematic reviews. Databases were searched till May 2023 using different search strategies as per the database. Title and abstract screening, followed by full-text screening and data extraction with risk of bias, was done by two independent reviewers in Covidence. Outcomes were reported as risk ratio (RR) or mean difference (MD) for dichotomous or continuous outcomes, respectively, using RevMan 5.4 (Review Manager 5.4) software. We used a random effect model for statistical analysis. Certainty of evidence was assessed using the Grading of Recommendation, Assessment, Development, and Evaluation Guideline Development Tool (GRADEpro GDT) software.

Results:
A total of 1145 reports were found from a database search. After screening, four studies were included for systematic reviews. Other occlusal splints reported were sagittal vertical extrusion device and mandibular ARS, full hard stabilization splint of canine or centric stabilization type. Data of only two studies could be used for meta-analysis having 30 participants received ARS and 40 received other occlusal splints. We did not find evidence of any difference between ARS and other occlusal splints for TMJ clicking in short term (RR 1.25, 95% confidence interval [CI] 0.91-1.72) but a small difference in favor of other occlusal splint in long term (RR 2.40, 95% CI 1.04–5.55). No evidence of any difference was found between both treatments for TMJ pain in short term (MD-5.68, 95% CI-17.31–5.95) and long term (MD 0.00, 95% CI-2.86–2.86) and muscle pain in short term. The certainty of evidence for comparison of two treatments for different outcomes was of low or very low level.

Conclusion:
Evidence is uncertain that other occlusal splints reduced TMJ clicking slightly in comparison to ARS. For the remaining outcomes, no evidence of any difference was found between the two splints and it may be biased due to selection bias, inadequate blinding of participants, and outcome assessor.
Comparative evaluation of masticatory efficiency, clinical performance, and patient satisfaction of single implant-retained mandibular overdenture versus conventional complete denture: A prospective in vivo study
Authors: Mathew Jemin Elizabeth , Kurian Nirmal , Gandhi Nitasha , Daniel Angleena Y. , Roy Neethu , Varghese Kevin George 
Published: August 2024

Aim:
The aim of this within-subject prospective clinical study was to investigate the scope of single implant mandibular overdenture by assessing its masticatory efficiency, clinical performance, and patient satisfaction compared to conventional complete dentures.

Settings and Design:
Prospective In Vivo Study.

Material and Methods:
This prospective in vivo study was conducted in the Department of Prosthodontics and Crown and Bridge, Christian Dental College, Ludhiana. A total of 12 completely edentulous patients received a single implant in the mandibular anterior midline region. After the healing period, the conventional maxillary and mandibular dentures were fabricated. 15 days post insertion of the conventional dentures, patients were evaluated for masticatory efficiency, clinical performance including retention and stability, and patient satisfaction. To evaluate the masticatory efficiency blue raspberry and original pink “Hubba Bubba tape gum” were used as a test food. Colorimetric analysis was done to assess variance of hue. To assess clinical performance, retention, and stability of the mandibular denture was recorded using a digital force gauge and was tabulated as per CU-modified Kapur's criteria. OHIP-14 index was used to assess patient satisfaction. After evaluation of the parameters of conventional dentures, the denture was converted into an implant-retained mandibular denture by chairside conversion with locator attachments. 15 days post-implant loading, parameters of the implant retained mandibular overdenture were assessed again followed by statistical analysis.

Statistical Analysis Used:
The masticatory efficiency was assessed using a paired t-test. The patient satisfaction was sequentially assessed with Wilcoxon signed rank test and thereafter paired t-test was used to compare between conventional complete denture and overdenture. Clinical performance was assessed using the Wilcoxon signed rank test.

Results:
The masticatory efficiency of single implant mandibular overdenture was higher than that of conventional complete dentures. The clinical performance of the overdenture was higher than that of the conventional denture. Stability being a time-dependent parameter might need longer follow-ups for further conclusions. Patient satisfaction with single implant retained overdenture was significantly higher than conventional complete dentures.

Conclusion:
Single implant mandibular overdenture has improved masticatory efficiency, clinical performance, and patient satisfaction compared to conventional complete dentures.
The six-year prevalence of Crimean-Congo Hemorrhagic Fever (CCHF) in Erzurum, Turkey
Authors: Igan Hakan , Hanci Hayrunisa 
Published: August 2024

Background & objectives:
Crimean-Congo Hemorrhagic Fever disease (CCHF) is a potentially deadly viral disease and Turkey is the country in which the disease is seen the most. The purpose of this study is to estimate the frequency and case fatality ratio (CFR) of CCHF disease in Erzurum/Turkey between years 2015-2021.

Methods:
The CCHF positivity in patients was detected on serum samples via RT-PCR method with RNA detection. Demographic data belonging to positive patients, such as, age, sex, region of residence, tick contact was analyzed retrospectively.

Results:
It was detected that the RT-PCR test of 521 patients out of a total of 1378 sent to the laboratory were positive. Each sample belonged to a single patient and repeating samples were left out of the research. The year with least positive patient ratio in relation to potential CCHF positive samples was 2017 (21.12%) whereas the year with the most positivity ratio was 2020 (55.48%) The case fatality ratio in the six-year period was calculated to be 1.34%.

Interpretation & conclusion:
This study has demonstrated that there is a significant rise in CCHF patient numbers, especially in 2020 when the Covid-19 pandemic started. In order to prevent this rise, it is crucial that the effect of Covid-19 pandemic on the increase in interactions of humans with ticks is researched thoroughly, a biological intervention is made and the public awareness on CCHF disease is increased.
A study on evaluation and correlation of serological methods and platelet count for diagnosis of dengue virus infection
Authors: Gohel Vidhi K , Gadhavi Hiral M , Shingala Hitesh K , Jethva Swati D 
Published: August 2024

Background & objectives:
Dengue is arthropod-borne, acute potentially fatal viral infection, endemic in many tropical and sub-tropical countries having public health threat globally in recent era. Effective and prompt diagnosis is very essential to reduce morbidity and mortality associated with severe form. Diagnosis by dengue-specific markers like Non-Structural protein 1 antigen or IgM/IgG antibody by serological method is the choice of investigation and the most widely used non-specific biomarker is platelet count. To evaluate and correlate results of two serological diagnostic methods (Dengue NS1 Antigen and Dengue IgM antibodies by Enzyme-Linked Immunosorbent Assay) and with platelet count for diagnosis of Dengue infection.

Methods:
Retrospective cross-sectional study for duration of 6 months from April 2022 to September 2022. Total 4063 serum samples of dengue suspected patients were tested according to duration of illness by ELISA for presence of NS1 Ag (≤5 days of illness) or IgM antibody (>5 days of illness).

Results:
393/4063 were detected positive by either method (NS1/IgM) and majority of patients were diagnosed between 3-8 days of illness. 248/2250 were tested positive for dengue NS1-Ag only, while 145/1813 were seropositive by dengue IgM only. Thrombocytopenia (platelet counts <100000/mm3) found in 301/393 seropositive cases which was also observed in NS1 (207/248 cases) and IgM (94/145 cases) seropositive patients.

Interpretation & conclusion:
Dengue specific parameters (NS1/IgM detection) in combination with platelet count helps in accurate, timely diagnosis and better monitoring in clinical management of patients.
Management outcome of congenital talipes equinovarus (clubfoot) using Ponseti protocol at Lagos University Teaching Hospital
Authors: Enweluzo George Okwudilichukwu , Ohadugha Adaugo G , Ezenwa-Ahanene Ikenna C , Udechukwu Obinna I , Edem UtibeAbasi Ime 
Published: August 2024

Abstract

Background:
Idiopathic clubfoot occurs commonly in children with a prevalence of 1 in 1000. The Pirani scoring system, which consists of a midfoot contracture score and hindfoot contracture score, is traditionally used in assessing the severity of clubfoot deformity. Ponseti protocol is used in the management of clubfoot deformity. The study aimed to evaluate the outcome of the management of clubfoot using the Ponseti protocol and to correlate the outcome with the initial Pirani score.

Materials and Methods:
Eighty-two children aged 1 week–2 years with 128 idiopathic clubfeet were recruited into the study. The severity of their clubfoot deformities was scored using the Pirani scoring system on recruitment. They were managed with weekly serial manipulation and cast application with or without tendon-Achilles tenotomy according to Ponseti protocol.

Results:
The average initial Pirani score was 3.6 ± 0.9. The average number of casts used was 5.9 ± 1.3 (range: 4–9 casts). Tenotomy was done in 51.56% of the feet. The group that required tenotomy required more casts and as such longer duration of treatment than the “no tenotomy” group. There was a relapse rate of 2% in the feet of the compliant group, whereas the relapse rate was 69% in the group that was not compliant with the use of foot-abduction brace. The success rate at 6 months follow-up was 84.4%.

Conclusions:
Ponseti protocol is an excellent method of management of idiopathic clubfoot, and the Pirani scoring system was useful in assessing the initial severity and the outcome. The initial Pirani score correlates with the duration of treatment.
The Recipe for Cure or Disaster?
Authors: Neliyathodi Suhail , Paul George , Gopinath Dhwani , Unais Sadakathulla 
Published: August 2024

Abstract
Drug-induced pulmonary toxicity is a rare adversity that occurs to a small minority of individuals on exposure to an agent. It may affect the alveoli, upper and lower airways, pleura, pulmonary vasculature, muscles of respiration, and the central nervous system governing respiratory controls. Here is a case about solving the mystery behind increased severity of respiratory symptoms in a known case of non-Hodgkin’s lymphoma on maintenance chemotherapy post complete response, and finding the agent of chaos.
Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis
Authors: Li Yan , Jiang Li-Na , Zhao Bo-Kang , Li Mei-Ling , Jiang Yi-Yun , Liu Yi-Si , Liu Shu-Hong , Zhu Li , Ye Xin , Zhao Jing-Min 
Published: August 2024

BACKGROUND
Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide, and metastasis is the main cause of early recurrence and poor prognosis. However, the mechanism of metastasis remains poorly understood.
AIM
To determine the possible mechanism affecting HCC metastasis and provide a possible theoretical basis for HCC treatment.
METHODS
The candidate molecule lecithin-cholesterol acyltransferase (LCAT) was screened by gene microarray and bioinformatics analysis. The expression levels of LCAT in clinical cohort samples was detected by quantitative real-time polymerase chain reaction and western blotting. The proliferation, migration, invasion and tumor-forming ability were measured by Cell Counting Kit-8, Transwell cell migration, invasion, and clonal formation assays, respectively. Tumor formation was detected in nude mice after LCAT gene knockdown or overexpression. The immunohistochemistry for Ki67, E-cadherin, N-cadherin, matrix metalloproteinase 9 and vascular endothelial growth factor were performed in liver tissues to assess the effect of LCAT on HCC. Gene set enrichment analysis (GSEA) on various gene signatures were analyzed with GSEA version 3.0. Three machine-learning algorithms (random forest, support vector machine, and logistic regression) were applied to predict HCC metastasis in The Cancer Genome Atlas and GEO databases.
RESULTS
LCAT was identified as a novel gene relating to HCC metastasis by using gene microarray in HCC tissues. LCAT was significantly downregulated in HCC tissues, which is correlated with recurrence, metastasis and poor outcome of HCC patients. Functional analysis indicated that LCAT inhibited HCC cell proliferation, migration and invasion both in vitro and in vivo . Clinicopathological data showed that LCAT was negatively associated with HCC size and metastasis (HCC size ≤ 3 cm vs 3-9 cm, P < 0.001; 3-9 cm vs > 9 cm, P < 0.01; metastatic-free HCC vs extrahepatic metastatic HCC, P < 0.05). LCAT suppressed the growth, migration and invasion of HCC cell lines via PI3K/AKT/mTOR signaling. Our results indicated that the logistic regression model based on LCAT, TNM stage and the serum level of α-fetoprotein in HCC patients could effectively predict high metastatic risk HCC patients.
CONCLUSION
LCAT is downregulated at translational and protein levels in HCC and might inhibit tumor metastasis via attenuating PI3K/AKT/mTOR signaling. LCAT is a prognostic marker and potential therapeutic target for HCC.
Nutritive and organoleptic evaluation of the African catfish (<i>Clarias gariepinus</i>) smoked with briquette and charcoal
Authors: Akinwole A.O. , Fawole O.O. , Oyediran F.S. 
Published: August 2024

Smoking is a preservation method which improves the nutritional value and organoleptic properties of fish. However, consumers are becoming more aware of possible hazards and detrimental health impacts arising from food they consume and are more demanding in respect of freshness, freedom from pollutant and other intrinsic qualities of smoked fish. The nutritive and organoleptic qualities of African Catfish smoked using charcoal and briquette as energy source were assessed. Sensory evaluation was conducted on tenderness, taste, juiceness, texture, colour and overall acceptability of the smoked fish samples based on 9-point Hedonic scale. Proximate and nutritive value of the smoked fish was also determined using standard methods. Data collected were analyzed using descriptive statistics. The mean value of crude protein, ash, ether extract, crude fibre and moisture content were 74.02±10.70, 4.53±1.20, 8.08±0.63, 8.08±0.63, 0.08±0.05 and 6.92±0.97 respectively for charcoal smoked fish samples and 76.86±2.95, 4.73±0.15, 8.08±0.33, 0.07±0.03 and 6.31±0.80 for briquette. The mean overall acceptability was also higher in charcoal (7.85±0.89) than briquette (7.72±0.52). T-test however showed that there was no significant difference (p>0.05) in the overall acceptability between charcoal and briquette. In conclusion, briquette produce good quality smoked fish just like charcoal.
Influence of Aframomum sceptrum Treatment on Hepatic Toxicity Induced by Monosodium Glutamate in Albino Rats
Authors: Iyeh Precious , Okpoghono Joel , George Betty O. 
Published: August 2024

Monosodium glutamate (MSG) is commonly used as a culinary flavouring, although research suggest that it is toxic to people and laboratory animals, especially in high dosages. The study goal is to determine the impact of Aframomum sceptrum (ataiko) treatment on hepatic induced toxicity by MSG. Thirty-six albino rats (male) with weight of 120 to 210 g were used for the study. The rats were separated into 6 groups in which each group contains six rats. Group 1: normal control. Group 2: MSG only. Group 3 and 4 were given MSG and then treated with 250 and 350 mg/kg b.wt of A. sceptrum extract respectively. Group 5 and 6 were administered only 250 and 350 mg/kg b.wt of A. sceptrum extract, respectively. The MSG groups were given intra-peritoneal injection of MSG solution at single dose of 4253 mg/kg b.wt. A. sceptrum extract was administered three times a week for four weeks beginning two days after the MSG induction. Liver function markers such as aspartate aminotransferase (AST) and alanine aminotransferase (ALT) and oxidative stress markers such as reduced glutathione (GSH) and malondialdehyde (MDA) were determined in serum and liver. Also, glucose was determined in the serum. The results showed that there were significant (p < 0.05) increased in glucose, AST, ALT and MDA in serum and liver, and decreased in GSH level in the liver of rats given MSG only when compared with normal control. However, A. sceptrum administration significantly (p < 0.05) decreased glucose, AST, ALT and MDA in the serum and liver, and increased GSH level in the liver when compared with MSG only. In conclusion, aqueous extract of A. sceptrum may have beneficial effect in MSG induced toxicity in rats by improving GSH level as well as liver function markers in a dose dependent manner.
Evaluación de la exposición a citostáticos en el personal de enfermería de atención primaria
Authors: Escandell Rico Francisco Miguel , Pérez Fernandez Lucia , Martínez Ribera Jose 
Published: August 2024

Introducción: El metotrexato es un fármaco citostático e inmunosupresor, de uso creciente en Atención Primaria para el tratamiento de ciertas enfermedades cancerígenas, problemas reumatológicos y dermatológicos entre otros. Por lo tanto, la presente investigación, plantea la necesidad de evaluar el manejo y la exposición del del metotrexato en el personal de enfermería, para describir el riesgo de exposición a los trabajadores que los manipulan.
Método: Se realiza un estudio descriptivo, transversal en donde, se utilizó un cuestionario para estudiar los factores que dificultan la aplicación de las practicas seguras en la administración del metotrexato por parte del personal de enfermería. Como criterio de inclusión se tuvo en cuenta la experiencia mínima de un año en la administración de medicación de las unidades a estudio.
Resultados: Participaron un total de 66 enfermeras. La edad media fue de 37,34 (DE 12,66). No se observaron diferencias significativas en las características del número de enfermeras en zonas básicas de salud con ≥25.000 o < 25.000 habitantes. En el cuestionario, se observó asociación significativa en la formación en el manejo de metotrexato (p < 0,002), la ventilación (p < 0,038) y señalización de la sala (p < 0,029).
Conclusiones: A nivel práctico, podemos interpretar satisfactoriamente los resultados obtenidos en nuestra investigación. También podría ayudar a mejorar el cumplimiento de los protocolos actuales y buscar estrategias para actualizar los conocimientos y habilidades relacionadas con al manejo y la exposición de las/os enfermeras/os en los centros de atención primaria.
Miradas desde el futuro: juego, narrativa y prospectiva especulativa. El origen, la evolución y los aprendizajes detrás del Futuroscopio
Authors: Alatorre Guzmán Diego , De Paz Ramírez Miguel 
Published: August 2024

Esta contribución tiene como objetivo compartir la filosofía, el proceso, los resultados y la reflexión detrás del Futuroscopio, un juego de rol a través del cual los jugadores se embarcan en una expedición para rescatar y asumir su agencia sobre la construcción colectiva del porvenir. El diseño del juego refleja un proceso participativo a lo largo de diferentes iteraciones que dan forma y estructuran una narrativa fantástica, que lleva a la tripulación (jugadores) a través de un viaje reflexivo inspirado en sus propios miedos y expectativas. Desde una perspectiva didáctica, esta experiencia supone una inmersión profunda en la pedagogía del juego, en tanto que refleja las diferentes etapas e iteraciones de un proceso de aprendizaje en diseño que oscila entre la experimentación heurística y la asimilación reflexiva, con un enfoque integral que se nutre de la participación abierta de múltiples actores, denominados en este artículo diseñadores~jugadores. Nos enfocamos no solo en los resultados, sino en las dinámicas sociales mediante las cuales los participantes entablan un diálogo creativo, subrayando la importancia del juego como un medio para abordar dilemas locales y relevantes. Finalmente, las conclusiones apuntan hacia un territorio poco explorado, donde el juego no se limita al ámbito de la educación básica, sino que se extiende como una actitud continua y presente en todos los campos profesionales y transversal al pensamiento disciplinar.