bluuebunny/crossref_metadata_2025_split huggingface dataset:
Having been bullied in childhood: Relationship to aggressive behaviour in adulthood
Authors: Sansone Randy A , Leung Justin S , Wiederman Michael W 
Published: September 2012

Aims: Victimization through being bullied in childhood is traditionally associated with subsequent internalizing symptoms, but some literature suggests otherwise. In this study, we examined a history of being bullied in relationship to 21 externalized aggressive behaviours in adulthood. Methods: Using a cross-sectional approach and a self-report survey methodology, we examined a history of being bullied in childhood in relation to 21 aggression variables in a consecutive sample of 342 internal medicine outpatients. Results: In comparison with the not bullied, participants who reported having been bullied in childhood had a statistically significantly greater overall number of self-reported aggressive behaviours. Longer duration of being bullied was statistically significantly correlated with a greater number of reported aggressive behaviours. With regard to individual behaviours, four were statistically significantly associated with being bullied: hitting walls; intentionally breaking things; getting into fist fights; and pushing/shoving a partner. Conclusions: While relationships between bullying in childhood and subsequent internalizing symptoms have been well established, the present study indicates that bullying in childhood is also associated with externalizing/aggressive behaviours in adulthood.
Validation of the Modified Brief Fatigue Inventory in Head and Neck Cancer Patients
Authors: Aynehchi Behrad B. , Obourn Chelsea , Sundaram Krishnamurthi , Bentsianov Boris L. , Rosenfeld Richard M. 
Published: September 2012

ObjectiveThe aim of this study is to validate the Modified Brief Fatigue Inventory (MBFI). This is the first instrument designed to measure intensity and frequency of fatigue specifically in head and neck cancer patients, potentially allowing objective measurement in addressing this common symptom in a concise yet thorough fashion.Study DesignSurvey validation.SettingAcademic tertiary medical center.Subjects and MethodsThe 9‐item MBFI was administered to 52 consecutive cancer patients and 57 consecutive controls. Demographics, comorbidities, cancer site, and cancer stage were recorded. Psychometric properties and predictors of the MBFI were analyzed.ResultsThe MBFI 1‐week test‐retest reliability was excellent (r = 0.800, P <. 001). Internal consistency was also excellent (Cronbach’s α = 0.938). Construct validity of the MBFI compared with the previously validated Multidimensional Fatigue Symptom Inventory–Short Form was excellent (r = 0.814, P <. 001). Discriminant validity of cancer patients vs controls was significant (P =. 027). Predictors of increased MBFI score included American Society of Anesthesiologists (comorbidity) score (bivariate analysis, r = 0.287, P =. 039), cancer stage (analysis of variance, P =. 007), and adjuvant radiotherapy (t test, P =. 016). Cancer stage and comorbidity were further correlated with a multiple regression linear model. No significant relationship was found with age, sex, marital status, education, ethnicity, feeding tube, tracheostomy, or laryngectomy.ConclusionThe MBFI is a reliable and valid tool for measuring fatigue levels in head and neck cancer patients. In the context of initial assessment or posttreatment trending, this brief survey can be rapidly administered, providing valuable objective data on a very common and potentially debilitating symptom.
Interventions Designed to Prevent Anterior Cruciate Ligament Injuries in Adolescents and Adults
Authors: Gagnier Joel J. , Morgenstern Hal , Chess Laura 
Published: September 2012

Background: Anterior cruciate ligament (ACL) injuries are common, result in significant morbidity, and are expensive to repair surgically and to rehabilitate. Several randomized and observational studies have tested neuromuscular interventions as preventive measures for these injuries. Purpose: To conduct a systematic review and meta-analysis of all known comparative studies for estimating and testing the effect of neuromuscular and educational interventions on the incidence of ACL injuries in adolescents and adults, both male and female. Study Design: Systematic review and meta-analysis. Methods: Several databases were used to identify eligible studies through July 4, 2011: MEDLINE, EMBASE, SPORTDiscus, Cumulative Index to Nursing and Allied Health Literature, the Cochrane Central Register of Controlled Trials, and Health Technology Assessment. Eligible studies were assessed for risk of bias, and meta-analyses were performed on the estimated intervention effect (log incidence rate ratio) using inverse-variance weighting, subgroup analysis, and random-effects meta-regression to estimate the overall (pooled) effect and explore heterogeneity of effect across studies (measured by I2 and tested with the Q statistic). Results: Eight cohort (observational) studies and 6 randomized trials were included, involving a total of approximately 27,000 participants. The random-effects meta-analysis yielded a pooled rate-ratio estimate of 0.485 (95% confidence interval [CI], 0.299-0.788; P = .003), indicating a lower ACL rate in the intervention groups, but there was appreciable heterogeneity of the estimated effect across studies ( I2 = 64%; P = .001). In the meta-regressions, the estimated effect was stronger for studies that were not randomized, performed in the United States, conducted in soccer players, had a longer duration of follow-up (more than 1 season), and had more hours of training per week in the intervention group, better compliance, and no dropouts. Nevertheless, residual heterogeneity was still observed within subgroups of those variables ( I2 > 50%; P < .10). Conclusion: The authors found that various types of neuromuscular and educational interventions appear to reduce the incidence rate of ACL injuries by approximately 50%, but the estimated effect varied appreciably among studies and was not able to explain most of that variability. Clinical Relevance: Neuromuscular and educational interventions appear to reduce the incidence rate of ACL injuries by approximately 50%.
Comparative Effectiveness of Injection Therapies in Lateral Epicondylitis
Authors: Krogh Thøger Persson , Bartels Else Marie , Ellingsen Torkell , Stengaard-Pedersen Kristian , Buchbinder Rachelle , Fredberg Ulrich , Bliddal Henning , Christensen Robin 
Published: September 2012

Background: Injection therapy with glucocorticoids has been used since the 1950s as a treatment strategy for lateral epicondylitis (tennis elbow). Lately, several novel injection therapies have become available. Purpose: To assess the comparative effectiveness and safety of injection therapies in patients with lateral epicondylitis. Study Design: Systematic review and meta-analysis. Methods: Randomized controlled trials comparing different injection therapies for lateral epicondylitis were included provided they contained data for change in pain intensity (primary outcome). Trials were assessed using the Cochrane risk of bias tool. Network (random effects) meta-analysis was applied to combine direct and indirect evidence within and across trial data using the final end point reported in the trials, and results for the arm-based network analyses are reported as standardized mean differences (SMDs). Results: Seventeen trials (1381 participants; 3 [18%] at low risk of bias) assessing injection with 8 different treatments—glucocorticoid (10 trials), botulinum toxin (4 trials), autologous blood (3 trials), platelet-rich plasma (2 trials), and polidocanol, glycosaminoglycan, prolotherapy, and hyaluronic acid (1 trial each)—were included. Pooled results (SMD [95% confidence interval]) showed that beyond 8 weeks, glucocorticoid injection was no more effective than placebo (−0.04 [−0.45 to 0.35]), but only 1 trial (which did not include a placebo arm) was at low risk of bias. Although botulinum toxin showed marginal benefit (−0.50 [−0.91 to −0.08]), it caused temporary paresis of finger extension, and all trials were at high risk of bias. Both autologous blood (−1.43 [−2.15 to −0.71]) and platelet-rich plasma (−1.13 [−1.77 to −0.49]) were also statistically superior to placebo, but only 1 trial was at low risk of bias. Prolotherapy (−2.71 [−4.60 to −0.82]) and hyaluronic acid (−5.58 [−6.35 to −4.82]) were both more efficacious than placebo, whereas polidocanol (0.39 [−0.42 to 1.20]) and glycosaminoglycan (−0.32 [−1.02 to 0.38]) showed no effect compared with placebo. The criteria for low risk of bias were only met by the prolotherapy and polidocanol trials. Conclusion: This systematic review and network meta-analysis of randomized controlled trials found a paucity of evidence from unbiased trials on which to base treatment recommendations regarding injection therapies for lateral epicondylitis.
Improved Osteochondral Allograft Preservation Using Serum-Free Media at Body Temperature
Authors: Garrity Joseph T. , Stoker Aaron M. , Sims Hannah J. , Cook James L. 
Published: September 2012

Background: Osteochondral allografts (OCAs) are currently preserved at 4°C and used within 28 days of donor harvest. The window of opportunity for implantation is limited to 14 days due to a 2-week disease testing protocol. Hypothesis: Osteochondral allograft tissues stored at 37°C will have significantly higher chondrocyte viability, as well as superior biochemical and biomechanical properties, than those stored at 4°C. Study Design: Controlled laboratory study. Methods: Osteochondral allografts from 15 adult canine cadavers were aseptically harvested within 4 hours of death. Medial and lateral femoral condyles were stored in Media 1, similar to the current standard, or Media 2, an anti-inflammatory and chondrogenic media containing dexamethasone and transforming growth factor−β3, at 4°C or 37°C for up to 56 days. Chondrocyte viability, glycosaminoglycan (GAG) and collagen (hydroxyproline [HP]) content, biomechanical properties, and collagen II and aggrecan content were assessed at days 28 and 56. Five femoral condyles were stored overnight and assessed the next day to serve as controls. Results: Storage in Media 1 at 37°C maintained chondrocyte viability at significantly higher levels than in any other media-temperature combination and at levels not significantly different from controls. Osteochondral allografts stored in either media at 4°C showed a significant decrease in chondrocyte viability throughout storage. Glycosaminoglycan and HP content were maintained through 56 days of storage in OCAs in Media 1 at 37°C. There were no significant differences in elastic or dynamic moduli among groups at day 56. Qualitative immunohistochemistry demonstrated the presence of collagen II and aggrecan throughout all layers of cartilage. Conclusion: Osteochondral allograft viability, matrix content and composition, and biomechanical properties were maintained at “fresh” levels through 56 days of storage in Media 1 at 37°C. Osteochondral allografts stored at 4°C were unable to maintain viability or matrix integrity through 28 days of storage. These findings suggest that storage of OCAs in a defined media at 37°C is superior to current protocols (4°C) for tissue preservation prior to transplantation. Clinical Relevance: Storage of OCAs in serum-free chemically defined media at 37°C can increase the “window of opportunity” for implantation of optimal tissue from 14 days to 42 days after disease testing clearance.
Correlation of a Single Assessment Numeric Evaluation (SANE) Rating With Modified Cincinnati Knee Rating System and IKDC Subjective Total Scores for Patients After ACL Reconstruction or Knee Arthroscopy
Authors: Shelbourne K. Donald , Barnes Adam F. , Gray Tinker 
Published: September 2012

Background: Limited studies exist regarding how well a single assessment numeric evaluation (SANE) rating correlates with validated knee surveys. Purpose: To determine whether a SANE rating correlates positively with the International Knee Documentation Committee (IKDC) and the modified Cincinnati Knee Rating System (CKRS) total scores after knee surgery. Study Design: Cohort study (Diagnosis); Level of evidence, 2. Methods: Patients undergoing either anterior cruciate ligament (ACL) reconstruction or knee arthroscopy were prospectively given subjective evaluations yearly after surgery between January 2000 and June 2011. Subjective evaluations were obtained using modified CKRS and IKDC subjective knee surveys and a SANE rating. Interclass correlation coefficient was used to determine the correlation of the SANE rating to the survey total scores. Bland-Altman method was used to access precision and limits of agreement between scores. In addition, the data were analyzed according to sex and age categories (<18, 18-24, 25-40, >40 years). Results: A total of 11,939 surveys were collected from 3209 patients (mean, 3.7 surveys/person; range, 1-22) after ACL reconstruction with a mean survey age of 35.2 ± 11.9 years (range, 13-72). A total of 4615 surveys were collected from 1813 patients (mean, 2.6 surveys/person; range, 1-17) after knee arthroscopy with a mean survey age of 47.4 ± 14.6 years (range, 11-88). For patients who underwent ACL reconstruction, the SANE rating had a moderate positive correlation of 0.66 to the total survey scores. For patients who underwent knee arthroscopies, the SANE rating had a strong positive correlation of 0.74 to total scores. There was minimal difference in correlations based on age group or sex. Bland-Altman analysis showed that the limits of agreement between the SANE score and the 2 surveys were met for at least 94% of patients in both patient groups. Conclusion: The SANE ratings exhibited moderate to strong positive correlations with the modified CKRS and IKDC subjective surveys after ACL reconstruction and knee arthroscopy for patients of all ages and both sexes.
An Analysis of Specific Lower Extremity Injury Rates on Grass and FieldTurf Playing Surfaces in National Football League Games
Authors: Hershman Elliott B. , Anderson Robert , Bergfeld John A. , Bradley James P. , Coughlin Michael J. , Johnson Robert J. , Spindler Kurt P. , Wojtys Edward , Powell John W. ,   for the National Football League Injury and Safety Panel, Collins James T. , Casolaro M. Anthony , Mayer Thom , Pellman Elliot , Tessendorf William , Tucker Andrew 
Published: September 2012

Background: Players in the National Football League (NFL) sustain injuries every season as the result of their participation. One factor associated with the rate of injury is the type of playing surface on which the players participate. Hypothesis: There is no difference in the rate of knee sprains and ankle sprains during NFL games when comparing rates of those injuries during games played on natural grass surfaces with rates of those injuries during games played on the artificial surface FieldTurf. Study Design: Descriptive epidemiology study. Methods: The NFL records injury and exposure (ie, game) data as part of its injury surveillance system. During the 2000-2009 NFL seasons, there were 2680 games (5360 team games) played on grass or artificial surfaces. Specifically, 1356 team games were played on FieldTurf and 4004 team games were played on grass. We examined the 2000-2009 game-related injury data from those games as recorded by the injury surveillance system. The data included the injury diagnosis, the date of injury, and the surface at the time of injury. The injury data showed that 1528 knee sprains and 1503 ankle sprains occurred during those games. We calculated injury rates for knee sprains and ankle sprains—specifically, medial collateral ligament (MCL) sprains, anterior cruciate ligament (ACL) sprains, eversion ankle sprains, and inversion ankle sprains—using incidence density ratios (IDRs). We used a Poisson model and logistic regression odds ratios to validate the IDR analysis. A multivariate logistic regression model was used to adjust the odds ratio for weather conditions. Results: The observed injury rate of knee sprains on FieldTurf was 22% (IDR = 1.22, 95% confidence interval [CI], 1.09-1.36) higher than on grass, and the injury rate of ankle sprains on FieldTurf was 22% (IDR = 1.22, 95% CI, 1.09-1.36) higher than on grass. These differences are statistically significant. Specifically, the observed injury rates of ACL sprains and eversion ankle sprains on FieldTurf surfaces were 67% ( P < .001) and 31% ( P < .001) higher than on grass surfaces and were statistically significant. The observed injury rates of MCL sprains and inversion ankle sprains were also not significantly higher on FieldTurf surfaces ( P = .689 and .390, respectively). Conclusion: Injury rates for ACL sprains and eversion ankle sprains for NFL games played on FieldTurf were higher than rates for those injuries in games played on grass, and the differences were statistically significant.
Turbo-discharging turbocharged internal combustion engines
Authors: Williams AM , Baker AT , Garner CP , Vijayakumar R 
Published: September 2012

Turbo-discharging is a novel approach that can better utilize the energy recoverable by a turbine (or series of turbines) mounted in the exhaust flow of internal combustion engines. The recovery of blowdown pulse energy in isolation of displacement pulse energy allows the discharging (depressurization) of the exhaust system to reduce engine pumping work and improve engine fuel economy. This is a novel approach to air system optimization that has previously been studied for naturally aspirated engines. However, to be successful, turbo-discharging should be applicable to turbocharged engines, as downsizing is a promising direction for future powertrain systems. This study uses one-dimensional gas dynamics modelling to explore the effect of turbo-discharging on a turbocharged gasoline engine, particularly focusing on the interaction with the turbocharging system. The results show that the peak engine torque is increased at low to mid speeds with high speed torque slightly reduced due to restrictions in engine breathing with low lift exhaust valves. The engine peak torque as a function of speed with a larger turbocharger and turbo-discharging was comparable to that of the smaller turbocharger without turbo-discharging. Fuel economy improvements were evident over most part-load regions of the engine map, with peak values varying from 2 to 7% depending on the baseline engine air system strategy. Hot trapped residual mass was consistently reduced across a large fraction of the engine map, with the exception of high power conditions, where the valve pressure drop effect dominated. This is expected to enable spark advance and further fuel economy benefit. The results from this study are promising and show that the use of some of the available exhaust gas energy for turbo-discharging in preference to turbocharging can have a positive effect on both part-load and full-load engine performance. There remains significant potential for further optimization with application of variable valve actuation and turbocharger control systems (for example, variable geometry turbines).
Long-Term Trend of Indoor Volatile Organic Compounds – a 15-Year Follow-Up Considering Real Living Conditions
Authors: Herbarth Olf , Matysik Silke 
Published: September 2012

Indoor volatile organic compounds (VOCs) may be associated with adverse health effects. The aim of this study was to investigate whether the indoor VOCs exposure burden has undergone changes during a past 15-year period, exemplarily in a German city. The study was limited to homes with families. To avoid possible regional-specific confounder effects, this assessment was conducted for this urban centre with a sufficiently long and continuous time series (1994–2008). VOCs were determined using passive sampling over 4 weeks followed by liquid extraction and analysis with gas chromatography-mass spectrometry. All measurement periods were equally distributed over the seasons and years. A substantial reduction in the total sum of VOCs and aromatics could be demonstrated as well as a trend of decrease concentrations for alkanes. No such changes could be observed for cycloalkanes, chlorinated hydrocarbons and terpenes group. Possible reasons for the reduction of indoor VOCs exposure are most likely due to the applied regulations/guidelines for the VOCs reduction in indoor-relevant products. Problems are, however, regarding the slight increase in terpene exposure. These chemicals have been found to be associated with quite specific health effects. Therefore, future emphasis should be directed not only towards the general reduction of anthropogenically generated VOC exposures in the outdoor environment but also on the reduction of health-relevant VOCs, especially indoors.
Renal function in a large cohort of metformin treated patients with type 2 diabetes mellitus
Authors: Sterner Gunnar , Elmståhl Sölve , Frid Anders 
Published: September 2012

Objectives To survey renal function in a defined population on metformin treatment. Methods All patients in the city of Malmö who collected at least three prescriptions of metformin during two years were identified from a central registry at the National Board of Health and Welfare in Sweden. Estimated glomerular filtration rate (eGFR), from the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) formula, of 5,408 patients were compared with a control population (n=2,815) from the same town. All cases of severe lactic acidosis leading to intensive care unit admission were also sought. Results In patients >79 years of age, 38% and 12% of patients had a best recorded eGFR registered below 60 and 45 ml/min/1.73 m2 respectively. In the age group 70–79 years the corresponding figures were 16% and 3% respectively. The eGFR was significantly higher in metformin treated patients than in control subjects in each age group. Three cases of lactic acidosis were recorded during the 2-year period studied. No patient with lactic acidosis was found in the highest age group. Conclusions In spite of reduced and fluctuating GFR in elderly patients, treatment with metformin is feasible. Adjusting the dose of metformin to renal function and adequately informing the patient could enable continuous treatment in moderately reduced GFR.
IFNγR signaling mediates alloreactive T-cell trafficking and GVHD
Authors: Choi Jaebok , Ziga Edward D. , Ritchey Julie , Collins Lynne , Prior Julie L. , Cooper Matthew L. , Piwnica-Worms David , DiPersio John F. 
Published: September 2012

Abstract
The clinical goal of allogeneic hematopoietic stem cell transplantation (allo-HSCT) is to minimize GVHD while maintaining GvL. Here, we show that interferon γ receptor-deficient (IFNγR−/−) allogeneic Tconv, which possess normal alloreactivity and cytotoxicity, induce significantly less GVHD than wild-type (WT) Tconv. This effect is mediated by altered trafficking of IFNγR−/− Tconv to GVHD target organs, especially the gastrointestinal (GI) tract. We show that the chemokine receptor CXCR3 is induced via IFNγR-mediated signaling and partially contributes to the trafficking of WT Tconv to GVHD target organs. Indeed, CXCR3−/− Tconv recapitulate the reduced GVHD potential of IFNγR−/− Tconv in a minor-mismatched GVHD model. Most importantly, IFNγR−/− (and CXCR3−/−) Tconv mediate a robust and beneficial GvL effect. In addition, we show that IFNγR−/− regulatory T cells (Tregs) are fully suppressive in vitro although defective in suppressor function in vivo and that WT Tregs suppress GVHD in vivo only when allogeneic Tconv produce interferon γ (IFNγ), suggesting that the IFNγR signaling pathway is the major mechanism for both Tregs and Tconv to migrate to GVHD target organs. Finally, pharmacologic inhibition of IFNγR signaling with inhibitors of JAK1/JAK2, which are mediators of IFNγR signaling, results in the decreased expression of CXCR3 and reduced GVHD and improved survival after allo-HSCT and this effect is mediated by altered trafficking of Tconv to GVHD target organs.