bluuebunny/crossref_metadata_2025_split huggingface dataset:
Diagnosis of Renal Tumors in Birt-Hogg-Dube Syndrome: Clinical Presentation and Risk Factors in a Single-center Retrospective Cohort
Authors: Kijlertsuphasri Supiya , Petnak Tananchai , Moua Teng 
Published: July 2024

Abstract

Background: Birt-Hogg-Dube (BHD) syndrome is a rare genetic condition associated with the development of renal tumors. This study aims to determine typical age ranges for detecting renal abnormalities, risk factors for tumor development, and long-term outcomes based on current surveillance strategies.
Methods: A single-center multi-site retrospective cohort study was performed on all patients with BHD diagnosed from 2000 to 2023. Baseline demographics, pulmonary function, laboratory, radiologic, and histopathologic findings were collected. Logistic regression was used to assess predictor variables for the development of renal tumors with survival analysis evaluated from the date of BHD diagnosis to date of death or last known follow-up.
Results: The study included 149 patients with BHD, 39 (26%) with diagnosed renal tumors, of which 28 had histopathologic confirmation. Mean age at renal tumor detection was 53.61 years. Older age and male sex were predictive of renal tumor development ((odds ratio 1.05; 95% CI, 1.01-1.08, P = 0.002) and (odds ratio 2.59; 95% CI, 1.17-5.73, P=0.02), respectively). Time to all-cause mortality appeared shorter in those with renal tumors (Log-rank P = 0.02), though no deaths were from cancer or cancer-related complications.
Conclusions: Current screening protocols for renal tumors in BHD suggest the most common presenting age range for presentation is late 40s to early 50s, with older age and male sex as risk factors for tumor development.
Health Education Programs for Hearing and Vision Impaired Individuals: A Scoping Review
Authors: Jin Sohyun , Ko Geumbo , Song Youngshin 
Published: July 2024

Abstract

Background
Individuals with disabilities encounter several challenges such as limited educational opportunities, restricted access to academic resources, and delays or shortages of support services. These challenges impede their access to medical services, a critical aspect of their well-being. This study aims to examine the current status of health education by selecting and analyzing health education programs for the visually and hearing impaired using the scoping review method.
Methods
Research questions were organized into population groups, concepts, and contexts following the established guidelines. Data comprised research papers on health education programs for individuals with visual and hearing impairments. Databases searched included Cochrane, Ovid MEDLINE, and Google Scholar for gray literature. The search strategy employed specific keywords and key phrases. Selection criteria focused on literature evaluating the educational impact in intervention studies (experimental and quasi-experimental) of health education programs for visually and hearing impaired individuals, sourced globally. Two independent researchers reviewed Eligible full-text articles and extracted data into a standardized table. The analysis results were summarized using descriptive statistics, including frequency and percentage.
Results
The literature search identified 3,168 articles, 34 of which were selected for analysis. Among these, 19 pertained to the visually impaired, while 15 focused on hearing impaired. Interventions for the visually impaired predominantly addressed acquisition and development, primarily through face-to-face sessions. Healthcare providers predominantly facilitated these interventions, primarily within healthcare institutions. Similarly, interventions for the hearing impaired primarily concentrated on acquisition and development, mainly through face-to-face interactions. The dropout rates averaged approximately 25.7% for the visually impaired and 23% for the hearing impaired. Outcome variables included physical function, psychosocial factors, behavior-related variables, and knowledge-related variables in both cohorts.
Conclusions
This scoping review undertaken in this study presents an exhaustive examination of tailored health education programs for individuals with visual and auditory impairments. The findings provide new insights into the effects of specific intervention types and the challenges faced by individuals with visual and hearing impairments. This underscores the necessity for continuous innovation and research directed toward enhancing health education strategies.
Development of machine learning-based differential diagnosis model and risk prediction model of organ damage for severe Mycoplasma pneumoniae pneumonia in children
Authors: He Bing , Li Xuewen , Dong Rongrong , Yao Han , Zhou Qi , Xu Changyan , Shang Chengming , Zhao Bo , Zhou Huiling , Yu Xinqiao , Xu Jiancheng 
Published: July 2024

Abstract

Objective Severe Mycoplasma pneumoniae pneumonia (SMPP) poses significant diagnostic challenges due to its clinical features overlapping with those of other common respiratory diseases. This study aims to develop and validate machine learning (ML) models for the early identification of SMPP and the risk prediction for liver and heart damage in SMPP using accessible laboratory indicators.
Methods Cohort 1 was divided into SMPP group and other respiratory diseases group. Cohort 2 was divided into myocardial damage, liver damage, and non-damage groups. The models built using five ML algorithms were compared to screen the best algorithm and model. Receiver Operating Characteristic (ROC) curves, accuracy, sensitivity, and other performance indicators were utilized to evaluate the performance of each model. Feature importance and Shapley Additive Explanation (SHAP) values were introduced to enhance the interpretability of models. Cohort 3 was used for external validation.
Results In Cohort 1, the SMPP differential diagnostic model developed using the LightGBM algorithm achieved the highest performance with AUCROC=0.968. In Cohort 2, the LightGBM model demonstrated superior performance in distinguishing myocardial damage, liver damage, and non-damage in SMPP patients (accuracy=0.818). Feature importance and SHAP values indicated that Age and CK-MB emerged as pivotal contributors significantly influencing Model 2’s output magnitude. The diagnostic and predictive abilities of the ML models were validated in Cohort 3, demonstrating the models had some clinical generalizability.
Conclusion The Model 1 and Model 2 constructed by LightGBM algorithm showed excellent ability in differential diagnosis of SMPP and risk prediction of organ damage in children.
The association between 24-hour movement behaviours and adiposity among Australian preschoolers: a compositional data analysis
Authors: Decraene Marga , Chong Kar Hau , Stanford Ty , Dumuid Dorothea , Cross Penny , Cardon Greet , Verbestel Vera , De Craemer Marieke , Okely Anthony 
Published: July 2024

Abstract

Introduction
The relationship between 24-hour movement behaviours (i.e. physical activity, sedentary behaviour and sleep) and adiposity in preschoolers remains unclear. Therefore, this study aims to investigate the associations between 24-hour movement behaviours and adiposity in preschoolers making use of compositional data-analysis (CoDA).
Methods
Australian preschoolers (3–5 years) from the Early Start Baseline Study wore an ActiGraph accelerometer to assess sedentary behaviour (SB), light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA). Their weight and height were measured using standardizes protocols and converted to Body Mass Index (BMI) z-scores using the World Health Organisation growth references. Their parents completed a questionnaire to assess their level of education and the child’s sleep duration, age and sex. CoDA was employed to investigate the association between 24-hour movement behaviours and adiposity in R.
Results
This study included 174 preschoolers and their overall 24-hour movement behaviour composition was associated with BMI z-scores (F = 4.09, p = 0.008). When examining the association between each movement behaviour relative to the others and BMI z-scores, we observed a statistically significant association for MVPA (p = 0.023), but not for the other behaviours. For example, reallocating 10 min from MVPA, proportionally to the other behaviours resulted in a difference of + 0.069 in BMI z-score.
Conclusion
Despite the association between more time spent in MVPA and higher BMI z-scores, a healthy amount of time spent in each of the 24-hour movement behaviours should be stimulated. Future studies should address methodological challenges, use larger and more diverse samples, and consider longitudinal designs. Additionally, a focus on sex- and age-specific adiposity indicators beyond BMI z-scores could enhance understanding of these relationships.
Completion of Maternal and Child Health Continuum of Care and Associated Factors in West Gondar Zone, North West Ethiopia, 2023: A Community Based Cross Sectional Study
Authors: Tegegne Asrat Mekonnen , Habitu Yohannes Ayanaw , Ferede Yeshiwas Ayale , Fentie Elsa Awoke 
Published: July 2024

Abstract

Background
The maternal and child health continuum of care encompasses integrated service delivery spanning prepregnancy through childhood, aiming to enhance maternal and child health outcomes. Recognized as pivotal in reducing maternal and newborn mortality rates, it focuses on improving maternal and neonatal health and well-being. Despite its importance, there remains a scarcity of comprehensive studies on maternal and child health continuums of care. This study aimed to assess the completion of the maternal and child health continuum of care and its influencing factors among mothers with index children aged 12–23 months in the West Gondar Zone, Northwest Ethiopia, in 2023.
Methods
A community-based cross-sectional study was conducted from May 1–30, 2023, by interviewing mothers of 12-23-month-old index children living in the West Gondar zone. A simple random sampling method was used to select 1019 mothers whose index child was 12–23 months old. The data were collected through KoboCollect android v2022 4.4 and imported to Stata version 14.0 for analysis. Binary logistic regression was used to examine the associations between the independent variables and continuum of care. Variables with a p value < 0.2 in the bivariable logistic regression analysis were chosen for the multivariable logistic regression model. Finally, an adjusted odds ratio with a 95% confidence interval and a p value < 0.05 were used to determine the statistical significance of the associations. The Hosmer and Lemeshow goodness-of-fit test was computed.
Results
The overall rate of completion of the maternal and child health continuum of care was 6.19% (95% CI: 4.69–7.68). Associated factors were first ANC visit before 16 weeks of pregnancy [AOR:4.25(2.14–8.47)], mothers well prepared for birth preparedness and complication readiness [AOR: 3.02(1.41–6.46)], history of modern contraceptive utilization [AOR:2.34 (CI: 1.16–4.73)], intended pregnancy [AOR: 3.25 (CI; 1.63–6.48)], maternal services during their ANC visit [AOR: 2.69(1.07–6.80)] and health facility that took less than an hour from home [AOR: 2.53 (CI; 1.06–6.03)].
Conclusions
The maternal and child health continuum of care in West Gondar was low. Birth preparedness and complication readiness, early initiation of ANC visits, planned pregnancy, family planning utilization, nearest health facility and maternal health service provision during ANC were factors affecting mothers’ ability to stay along the path of the MCH continuum of care. Efforts should be focused on those factors to improve the completion of maternal and child health care and to provide appropriate services at each level of the continuum.
Epoxy Resin Curing Using Solid Hardener in the Solution Phase: Study on Effect of the Presence of the Amino Group in Solvent on Epoxy Curing
Authors: BHALERAO PRAVIN , BALOCH MUSKANBANU , Soni Mital R , Mayani Suranjana V. , KAVAR TEJAS , Jadeja Poojaba , Jadeja Riddhi , Khorajiya Suzanabanu , Gandhi Brijesh , Ranpara Prince 
Published: July 2024

Abstract

Epoxy curing is crucial in many applications, including paint, reinforced composites, and material coating. In this work, 2–4 dinitro phenyl hydrazine is used as a solid hardener as a curing agent for epoxy curing. Curing was performed on a glass petri dish and in a beaker, at high temperature using a hot air oven as well as a sand bath. Solid hardner were used for curing epoxy with different percentages hydrazine, in acetone and acetone/aniline as a solvent. Epoxy resin curing analysis was confirmed by FTIR, and UV-visible spectroscopic analysis. The thermal stability of cured epoxy material has been studied using DSC. The coating of epoxy resin was stable in different organic solvents and dissolved in acetone. This coating shows chemical resistance to saturated solution of strong base (NaOH), and also showed stability in strong acids (HCl, HNO3) this suggests anti-corrosion behavior in acidic and basic mediums. A short curing time (5–10 minutes), a small amount of curing agent, and a conventional heating source in a sand bath and hot air oven in solution with organic solvents (acetone/aniline) are key features of our curing approach.
Development and validation of a nomogram to predict pathological complete response following neoadjuvant chemotherapy in luminal breast cancer based on clinicopathological features
Authors: Safi Sarah Al , Kim Hee Jeong , Kim Jisun , Yoo Tae-Kyung , Chung Il Yong , Ko Beom Seok , Lee Jong Won , Son Byung Ho , Lee Sae Byul 
Published: July 2024

Abstract

Purpose:
Luminal breast cancer is the most common subtype of breast cancer with a favorable prognosis but shows the lowest response to neoadjuvant chemotherapy (NACT), with most patients not achieving pathological complete response (pCR). Because pCR is a crucial predictor of treatment success, this study developed a nomogram to predict pCR following NACT in luminal breast cancer based on clinicopathological features.
Methods:
This retrospective study included patients diagnosed with luminal breast cancer at Asan Medical Center, Seoul, Republic of Korea, who received NACT and underwent breast cancer surgery between August 2008 and December 2021. Logistic regression multivariate analysis was used to identify independent predictors of pCR. The receiver operating characteristic analysis was applied to determine the nomogram accuracy.
Results:
Data from 1,574 patients were collected; 22.2% achieved a complete response, while 77.8% did not. The sample was divided into a training group (2008 to 2018, n = 1,244) and a validation group (2019 to 2021, n = 330). Multivariate logistic regression showed clinical tumor stage, estrogen receptor (ER) Allred score, progesterone receptor (PR) Allred score, and Ki67 index as independent predictors of pCR in the primary cohort. These variables were used to develop a nomogram predicting pCR in luminal breast cancer patients receiving NACT. The area under the ROC curve was 0.663 (95% confidence interval [CI], 0.623–0.703). For the validation group, the nomogram’s accuracy was confirmed with an area under the curve = 0.637 (95% CI, 0.572–0.702).
Conclusion:
Our study suggested that this nomogram, incorporating clinical tumor stage, ER Allred score, PR Allred score, and Ki67 index, can be effectively used to NACT in luminal breast cancer.
Exploration of High School Student-Athletes’ 24-Hour Movement Behaviors and Their Impact on Positive Mental Health
Authors: Sabourin Camille , Turgeon Stéphanie , Camiré Martin 
Published: July 2024

Abstract

Research indicates that movement behaviors are intricately linked to mental health outcomes. Although previous research has generally focused on the detrimental effects of poor movement behaviors, the present study took a closer look at how adherence to movement behavior guidelines may contribute to positive mental health outcomes among high school student-athletes. The Canadian 24-Hour Movement Behavior Guidelines (24-HMBG) were used to frame our assessment of movement behaviors, being respectively ≥ 60 minutes per day of moderate-to-vigorous physical activity, ≤ two hours per day of recreational screentime, and eight to ten hours of sleep per night for adolescents. Participants’ physical activity, screentime, and sleep time were assessed using self-reported survey data collected during the 2019-2020 school year. The Mental Health Continuum-Short Form was used to measure positive mental health. Although most participants met the physical activity guidelines, findings highlighted how only 1.56% of participants met all three 24-HMBG, demonstrating significant challenges in aligning daily behaviors with current recommendations. Furthermore, hierarchical multiple regression analyses revealed that screentime positively and sleep time negatively predicted positive mental health. Physical activity showed no significant association. The present study sheds light on the (mis)alignment of movement behaviors with recommended guidelines and suggests future research be conducted on how to best promote healthy behaviors and enhance mental well-being among high school student-athletes.
Retrospective investigation of medulloblastoma under three years of age based on methylation molecule type
Authors: Deng Kaiwen , Liu Hailong , Feng Jin , Chen Li , Liu Fei , Chen Xuan , Li Jiankang , Jiang Tao , Qiu Xiaoguang 
Published: July 2024

Abstract

Background
Medulloblastoma (MB), a prevalent malignant pediatric brain tumor, typically necessitates a comprehensive treatment regimen. However, the standard treatment paradigm is often not viable for infants (< 3 years old) incomplete, which contraindicates traditional radiotherapy. This study retrospectively analyzed the efficacy of chemotherapy with deferred radiotherapy in infants.
Methods
The cohort consisted of 23 infants who receiving surgical resection of MB, which has been categorized into SHH, Group_3, and Group_4 subgroups and received postoperative chemotherapy. Molecular subgroups were identified using DNA methylation sequencing. This study analyzed the overall survival and recurrence rates based on molecular subgroup and evaluated the effects of treatment strategies.
Results
SHH accounted for 48%, Group_3 for 40%, and Group_4 for 12%. The follow-up period ranged from 1 to 131 months, with a median of 51 months. The overall survival rate was 60%, with survival rates for SHH, Group_3, and Group_4 at 66.7%, 50.0%, and 66.7%, respectively. The survival rates at 1, 3, 5, and 10 years were 92%, 80%, 48%, and 12%, respectively. Univariate and multivariate Cox regression analyses indicated that recurrence and treatment modalities significantly impacted survival times, with a hazard ratio of 10.28 for recurrence (95% CI: 1.99–53.03, p = 0.005) and 4.59 for chemotherapy alone (95% CI: 1.11–18.93, p = 0.035). The findings suggest that for infants with MB, a combined treatment approach of postoperative chemotherapy followed by delayed radiotherapy significantly improves overall survival compared to chemotherapy alone.
Conclusion
The findings suggest that infants with MB benefit substantially from postoperative chemotherapy followed by delayed radiotherapy.
Prospective, Single-blind, Randomized Controlled Study of "Jetting Sutures" under Microendoscopic Discectomy Surgery in the Treatment of Single-segment Lumbar Disc Herniation with Four-year Follow-up
Authors: Li Kunpeng , Wang Chongyi , Hu Bingtao , Zhou Xin , Fu Qingyang , Lin Xiangyu , Wang Kaibin , Feng Yunze , Li Le , Si Haipeng 
Published: July 2024

Abstract

Study design: Prospective, single-blind, randomized controlled trial
Objective: The purpose of this study was to compare and contrast the outcomes of microendoscopic discectomy (MED) surgery with and without "jetting sutures".
Methods: Forty-eight cases underwent MED, of which 24 cases had annular jetting sutures applied, and all cases were followed up. The clinical data of the patients were assessed using the Japanese Orthopedic Association (JOA) score, Oswestry Disability Index (ODI), visual analog scale (VAS), and MacNab score to determine the level of lumbar function improvement.
Results: All operations were completed, which included 24 cases in the control group and 24 cases in the repair group. In both groups, the patients' VAS scores were significantly reduced, and their ODI scores and JOA scores were significantly improved (P <.05). At the four-year follow-up, the sensitivity of the injured nerve root, muscular strength, and achilles tendon reflex had all significantly recovered (P<.05), but the patellar reflex had not (P >.05). Overall, 95.8% of the repair group had excellent or good MacNab scores compared with 87.5% of the control group (P >.05).
Conclusion: The jetting suture technique can be performed safely and effectively in MED surgery. This study demonstrated that considering the efficacy of annular repair, jetting sutures applied to the treatment of lumbar disc herniation to prevent recurrence are safe, effective and worth promoting.
Trial registration: This prospective clinical trial was approved by the Medical Ethics Committee of Qilu Hospital of Shandong University (ethics approval number: 2013061) and registered with the Chinese Clinical Trial Registry (registration number: ChiCTR-TRC-14004332).
Warthin tumor concomitant with mantle cell lymphoma: a case report and review of literature
Authors: Tong Hai-Chao , Ma Shuang , Chen Lan , Meng Xiangyun , Li Ying-Chun , Li Le-Yao , Dong Lingyun , Zhang Wan-Lin , Wildes Tyler , Yang Lian-He , Wang Endi 
Published: July 2024

Abstract

Rationale:
Warthin tumor (WT) is the second most common benign tumor in salivary gland. It has a slow growth rate and most frequently occurs in parotid gland. Most patients present with incidental finding of painless masses inferior/anterior to the ear. Besides the epithelial component of the tumor, WT is characteristic of associated lymphoid stroma that is considered benign. While there have been few reports of malignant transformation of lymphoid components in WT, cases of WT concomitant with mantle cell lymphoma (MCL) are extremely rare. To the best of our knowledge two cases have described in English literature. Herein, we report a case of WT concomitant with MCL in a 70-year-old female patient, and emphasize the importance of careful examination of lymphoid stroma in WT so that the possibility of concurrent lymphoma would not be missed.
Patient concerns:
A 70-year-old Chinese woman with a 40-year history of cigarette smoking presented with a right submaxillary mass for the past year with recent enlargement.
Diagnosis:
Cervical ultrasound (US) and computed tomography (CT) scans of the neck revealed a well circumscribed mass lesion in the right parotid with a maximum diameter of 3.1 cm. Surgical resection of the mass was performed. Histopathological examination revealed a characteristic double-layers of neoplastic epithelium with prominent lymphoid stroma, suggesting WT. In addition, morphology and immunohistochemistry study confirmed the coexistance of MCL. Thereafter, the final diagnosis of this case was WT concomitant with MCL.
Interventions:
The patient was staged as stage IVa after clinical assessment. Due to the slow growth of parotid lesions, close observation was decided with periodic clinical and radiological monitoring.
Outcomes:
Currently, the patient demonstrates a stable disease by clinical evaluation
Lessons:
To the best of our knowledge, reported cases of WT concomitant with MCL are very rare. This case highlights the importance of a comprehensive assessment of the lymphoid stroma of WT to avoid missed diagnosis of lymphoma component in a collision tumor.