bluuebunny/crossref_metadata_2025_split huggingface dataset:
Resveratrol attenuates non-steroidal anti-inflammatory drug-induced intestinal injury in rats in a high-altitude hypoxic environment by modulating the TLR4/NFκB/IκB pathway and gut microbiota composition
Authors: Xue Shenglong , Shi Wenhui , Shi Tian , Tuerxuntayi Ailifeire , Abulaiti Paziliya , Liu Zhuoshuyi , Remutula Najimangu , Nuermaimaiti Kailibinuer , Xing Yingying , Abdukelimu Kudelaiti , Liu Weidong , Gao Feng 
Published: August 2024

Introduction
Non-steroidal anti-inflammatory drugs (NSAIDs) are currently the most widely used anti-inflammatory medications, but their long-term use can cause damage to the gastrointestinal tract(GIT). One of the risk factors for GIT injury is exposure to a high-altitude hypoxic environment, which can lead to damage to the intestinal mucosal barrier. Taking NSAIDs in a high-altitude hypoxic environment can exacerbate GIT injury and impact gut microbiota. The aim of this study is to investigate the mechanisms by which resveratrol (RSV) intervention alleviates NSAID-induced intestinal injury in a high-altitude hypoxic environment, as well as its role in regulating gut microbiota.

Methods
Aspirin was administered orally to rats to construct a rat model of intestinal injury induced by NSAIDs. Following the induction of intestinal injury, rats were administered RSV by gavage, and the expression levels of TLR4, NF-κB,IκB as well as Zonula Occludens-1 (ZO-1) and Occludin proteins in the different treatment groups were assessed via Western blot. Furthermore, the expression of the inflammatory factors IL-10, IL-1β, and TNF-α was evaluated using Elisa.16sRNA sequencing was employed to investigate alterations in the gut microbiota.

Results
The HCk group showed elevated expression of TLR4/NF-κB/IκB pathway proteins, increased expression of pro-inflammatory factors IL-1β and TNF-α, decreased expression of the anti-inflammatory factor IL-10, and expression of intestinal mucosal barrier proteins ZO-1 and Occludin. The administration of NSAIDs drugs in the plateau hypoxic environment exacerbates intestinal inflammation and damage to the intestinal mucosal barrier. After treatment with RSV intervention, the expression of TLR4/NF-κB/IκB signaling pathway proteins would be reduced, thereby lowering the expression of inflammatory factors in the HAsp group. The results of HE staining directly show the damage to the intestines and the repair of intestinal mucosa after RSV intervention. 16sRNA sequencing results show significant differences (P<0.05) in Ruminococcus, Facklamia, Parasutterella, Jeotgalicoccus, Coprococcus, and Psychrobacter between the HCk group and the Ck group. Compared to the HCk group, the HAsp group shows significant differences (P<0.05) in Facklamia, Jeotgalicoccus, Roseburia, Psychrobacter, and Alloprevotella. After RSV intervention, Clostridium_sensu_stricto bacteria significantly increase compared to the HAsp group.

Conclusion
Resveratrol can attenuate intestinal damage caused by the administration of NSAIDs at high altitude in hypoxic environments by modulating the TLR4/NF-κB/IκB signaling pathway and gut microbiota composition.
Detection and position evaluation of chest percutaneous drainage catheter on chest radiographs using deep learning
Authors: Kim Duk Ju , Nam In Chul , Kim Doo Ri , Kim Jeong Jae , Hwang Im-kyung , Lee Jeong Sub , Park Sung Eun , Kim Hyeonwoo 
Published: August 2024

Purpose
This study aimed to develop an algorithm for the automatic detecting chest percutaneous catheter drainage (PCD) and evaluating catheter positions on chest radiographs using deep learning.

Methods
This retrospective study included 1,217 chest radiographs (proper positioned: 937; malpositioned: 280) from a total of 960 patients underwent chest PCD from October 2017 to February 2023. The tip location of the chest PCD was annotated using bounding boxes and classified as proper positioned and malpositioned. The radiographs were randomly allocated into the training, validation sets (total: 1,094 radiographs; proper positioned: 853 radiographs; malpositioned: 241 radiographs), and test datasets (total: 123 radiographs; proper positioned: 84 radiographs; malpositioned: 39 radiographs). The selected AI model was used to detect the catheter tip of chest PCD and evaluate the catheter’s position using the test dataset to distinguish between properly positioned and malpositioned cases. Its performance in detecting the catheter and assessing its position on chest radiographs was evaluated by per radiographs and per instances. The association between the position and function of the catheter during chest PCD was evaluated.

Results
In per chest radiographs, the selected model’s accuracy was 0.88. The sensitivity and specificity were 0.86 and 0.92, respectively. In per instance, the selected model’s the mean Average Precision 50 (mAP50) was 0.86. The precision and recall were 0.90 and 0.79 respectively. Regarding the association between the position and function of the catheter during chest PCD, its sensitivity and specificity were 0.93 and 0.95, respectively.

Conclusion
The artificial intelligence model for the automatic detection and evaluation of catheter position during chest PCD on chest radiographs demonstrated acceptable diagnostic performance and could assist radiologists and clinicians in the early detection of catheter malposition and malfunction during chest percutaneous catheter drainage.
Evaluation of left ventricular ejection fraction by a new automatic tool on a pocket ultrasound device: Concordance study with cardiac magnetic resonance imaging
Authors: Berger Lucie , Coisy Fabien , Sammoud Skander , de Oliveira Fabien , Grandpierre Romain Genre , Grau-Mercier Laura , Bobbia Xavier , Markarian Thibaut 
Published: August 2024

Introduction
Assessment of left ventricular ejection fraction (LVEF) is one of the primary objectives of echocardiography. The gold standard assessment technique in emergency medicine is eyeballing. A new tool is now available on pocket ultrasound devices (PUD): automatic LVEF. The primary aim of this study was to evaluate the concordance between LVEF values estimated by automatic LVEF with PUD and by cardiac magnetic resonance imaging (MRI).

Materials
This was a prospective, monocentric, and observational study. All adult patients with an indication for cardiac MRI underwent a point-of-care ultrasound. Blinded to the MRI results, the emergency physician assessed LVEF using the automatic PUD tool and by visual evaluation.

Results
Sixty patients were included and analyzed. Visual estimation of LVEF was feasible for all patients and automatic evaluation for 52 (87%) patients. Lin’s concordance correlation coefficient between automatic ejection fraction with PUD and by cardiac MRI was 0.23 (95% CI, 0.03–0.40).

Conclusion
Concordance between LVEF estimated by the automatic ejection fraction with PUD and LVEF estimated by MRI was non-existent.
Factors Associated With Mailed Fecal Immunochemical Test Completion in an Integrated Academic-Community Healthcare System
Authors: Simpson Samuel , Yu Kaiyue , Bell-Brown Ari , Kimura Amanda , Meisner Allison , Issaka Rachel B. 
Published: August 2024

INTRODUCTION:
Mailed fecal immunochemical test (FIT) outreach is an effective strategy to increase colorectal cancer (CRC) screening. The aim of this study was to determine the patient-level, clinic-level, and geographic-level factors associated with CRC screening completion in a mailed FIT outreach program.

METHODS:
This retrospective cohort study was conducted in the integrated healthcare system of University of Washington Medicine and included patients aged 50–75 years, who were due for CRC screening, and had a primary care encounter in the past 3 years. Eligible patients received mailed outreach that included a letter with information about CRC screening, FIT kit, and a prepaid return envelope. CRC screening and factors associated with completion were obtained from electronic health records and the CRC screening program database.

RESULTS:
Of the 9,719 patients who received mailed outreach, 29.6% completed FIT mailed outreach. The median FIT return time was 27 days (interquartile range 14–54). On multivariate analysis, patients with a higher area deprivation index, insured through Medicaid, living without a partner, and whose last primary care visit was >12 months ago were less likely to complete a FIT compared with their counterparts. Over a 12-month period, overall CRC screening across the health system increased by 2 percentage points (68%–70%).

DISCUSSION:
Mailed FIT outreach in an integrated academic-community practice was feasible, with 32% of invited patients completing CRC screening by FIT or colonoscopy, on par with published literature. Patient and geographic-level factors were associated with CRC screening completion. These data will inform additional interventions aimed to increase CRC screening participation in this population.
Some applications and maximum principles for multi-term time-space fractional parabolic Monge-Ampère equation
Authors: Guan Tingting , Wang Guotao , Araci Serkan 
Published: August 2024

Abstract
This study first establishes several maximum and minimum principles involving the nonlocal Monge-Ampère operator and the multi-term time-space fractional Caputo-Fabrizio derivative. Based on the maximum principle established above, on the one hand, we show that a family of multi-term time-space fractional parabolic Monge-Ampère equations has at most one solution; on the other hand, we establish some comparison principles of linear and nonlinear multi-term time-space fractional parabolic Monge-Ampère equations.
An AMC-based low-RCS conformal phased array design
Authors: Guan Yangyang , Xin Hui , Cui Jiahe , Zhang Peng 
Published: August 2024

Abstract
In this article, an integrated radiation and scattering performance array conformed with the cylinder is presented. Wideband RCS reduction can be achieved and the radiating performance is maintained without loading any other structures. Two different antenna units with similar radiation performances and different reflection phases are designed to form a 6 × 6 conformal array. To verify the simulation results, a prototype of a 6 × 6 units integrated conformal array was fabricated and measured. The experimental results show that the proposed conformal array has better scanning performance above ±40° in the range of 8.2–11.3 GHz. In addition, the monostatic RCS reduction of the proposed array is more than 5 dB covering the working band of the array antenna with a maximum reduction value of 24.2 dB. The measured results agree well with the simulation results.
Determinants influencing tourists’ willingness to visit Türkiye – Impact of earthquake hazards on Serbian visitors’ preferences
Authors: Blešić Ivana , Ivkov Milan , Gajić Tamara , Petrović Marko D. , Radovanović Milan M. , Valjarević Aleksandar , Malinović-Milićević Slavica , Vukin Marina , Raljić Jovanka Popov , Puhar Dušan , Lukić Tin 
Published: August 2024

Abstract
Earthquakes are a rather complex natural phenomenon that cannot be prevented, and their effects can be catastrophic and have profound implications on various economic sectors (especially tourism). This study investigates the relationships between subjective factors (gender, age, education, previous experience, and disaster anxiety), the perceived travel risk, and the travel intention of tourists from Serbia to destinations in Türkiye. The pilot study was done in March 2023 with 110 respondents from the Faculty of Science, Department of Geography, Tourism, and Hotel Management, Novi Sad. After the validation of the instruments, the main survey was conducted in the period from March to June 2023. The subjects of interest were residents of Serbia over the age of 18. The data from this study are analyzed using the confirmatory factor analysis and path analyses. This study aims to enhance the understanding of perceived risk and travel intention, specifically focusing on Türkiye. The assessed outcome relates to how tourists perceive three specific categories of risk when traveling to destinations with a high risk of natural disasters, such as earthquake-prone areas. The findings suggest that older respondents tend to perceive lower physical and financial travel risks, even though the influence of age on the perception of socio-psychological risks was inconclusive. Further results reveal that individuals with prior experience tend to hold a heightened perception of physical, financial, and socio-psychological risks. An examination of the relationship between disaster anxiety and perceived travel risks indicates that physical, financial, and socio-psychological risks exert a negative influence on travel intention. Thus, this study may provide a conceptual foundation for both theoretical and practical implications for the improvement of risk management techniques at a specific travel destination in areas prone to earthquake hazards.
Activating sustainability in the design process
Authors: Miquel Andrea 
Published: August 2024

Abstract
Design decisions have an impact on societies and the environment. Making the impact of design tangible facilitates the mitigation of its negative consequences. The purpose of this paper is to outline what methods and actions a User Experience (UX) practitioner could use in order to support sustainable development. At Ergosign GmbH, an agency creating digital experiences, we conducted a review of existing guidelines and principles to determine the relevance and usefulness of those frameworks in the User Experience Design (UXD) context. The analysis resulted in the creation of six guiding principles to introduce sustainability concerns into the design process. Additionally, we mapped related UX methods and heuristics to each principle. Each of the six principles, as well as an exemplary method, are described in detail in this article. A first practical evaluation of the principles suggests that assessing impact and identifying preventive actions is possible at all stages of the design process. Furthermore, there is no strict correlation of a principle with a particular project phase. While an early analysis generates a more holistic action plan, a later assessment provides more concrete advice. Both approaches can deliver notable improvements in the reduction of resource usage.
The Riemann Hilbert dressing method and wave breaking for two (2 + 1)-dimensional integrable equations
Authors: Lu Huanhuan , Ren Xinan , Zhang Yufeng , Zhang Hongyi 
Published: August 2024

Abstract
In this article, we present a method for generating (2 + 1)-dimensional integrable equations, resulting in the generalized Pavlov equation and dispersionless Kadomtsev–Petviashvili (dKP) equation, which can further be reduced to the standard Pavlov equation and dKP equation. Inspired by the inverse spectral transform presented in existing literature, we introduce the Riemann–Hilbert (RH) dressing method to construct the formal solutions of the Cauchy problems for the generalized Pavlov equation and dKP equation, providing a spectral representation of the solutions. Subsequently, we also extensively investigate the longtime behavior of solutions to these two equations in specific space regions. In particular, for the generalized dKP equation, we conduct a dedicated study on its implicit solutions expressed by arbitrary differential function through linearizing their RH problems. In the final section, we elaborate in detail on the analytic aspects of the wave breaking of a localized two-dimensional wave evolving according to the Hopf equation. With the assistance of a transformation, the longtime breaking of solutions to the generalized dKP equation can then be further characterized.
Synergizing intelligent signal processing with wavelength-division multiplexing for enhanced efficiency and speed in photonic network communications
Authors: Saiyyed Riyaz , Sindhwani Manoj , Mishra Neeraj Kumar , Pahuja Hunny , Sachdeva Shippu , Shukla Manoj Kumar 
Published: August 2024

AbstractThe explosive growth of worldwide mobile data traffic seeks innovations in communication technology to cater to the mounting need for rapid connectivity, high-capacity connections. The mainstreaming of 5G technologies for communication is a dramatic step towards meeting the aforementioned goals, with the ability for reshaping IoT (Internet of things), D2D (device-to-Device) communications, and the smart grids. This work conveys an in-depth study of the fundamental innovations that underlie 5G, including full-duplex distribution, huge multiple-input-multiple-output, ultra-dense connections, the phenomenon of beamforming and millimeter-wave approaches. A special emphasis is focused on the integration of photonic technologies, or microwave photonics, which serves as a critical multidisciplinary study topic. Optical fibers, with their tremendous bandwidth and capacity, have been determined as the best medium for backhaul and fronthaul amenities, outpacing conventional copper cables to accommodate tiny cells and next-generation networks. The synergy between optical and wireless access technologies is analyzed with the emphasis on the central role of wavelength-division multiplexing (WDM) for improving network efficiency and speed. The investigation additionally explores the possibility of intelligent signal processing methods combined with WDM to optimize photonic network communications. The mingling of these technologies anticipates producing unrivaled levels of performance, rupturing the path for an additional intelligent, interconnected era.
Within the Range of the Watchtowers: Nature and Purpose of Late Bronze Age Hilltop Buildings in the Blagoevgrad Basin, Southwestern Bulgaria
Authors: Bahyrycz Cezary , Kulov Ilia , Hristov Pavel 
Published: August 2024

Abstract
The Struma/Strymon River valley, due to its key geographical position, carving a corridor in mountain massifs, served as a natural communication route between the north: south-eastern and central Balkans and further on – Central Europe, and the south: the coast of the Aegean Sea. The lack of detailed studies of the settlement pattern have not allowed for complete characterization of its role in the cultural contacts of prehistoric communities. Fortunately, this state of research is changing, due to the carrying out intensive field surveying, and recording of archaeological sites. As a result of it, evidence of the flourishing of settlements in the Late Bronze Age and the transition period between the Bronze Age and the Iron Age were recorded. In addition to flat settlements, “atypical” sites were also identified – called the Kamenska Chuka-type, named after the first discovered site of this type, located in naturally defensive and hard-to-reach places with a wide observation views. From the very moment of discovery, researchers have been speculating about the functions of these archaeological sites. The aim of this article is to attempt to explain some issues – nature and purpose related to Kamenska Chuka-type sites and verify the theses put forward by researchers of the topic, using geographic information system (GIS) technology and freely available spatial data, combining them with traditional archaeological data.
Non-islet cell tumor hypoglycemia that required immediate surgery after a long-term asymptomatic state: recommendation for early intervention
Authors: Kurihara Takashi , Fujimoto Kanta , Iwakura Toshio , Hataya Yuji , Yamashita Daisuke , Matsuoka Naoki 
Published: August 2024

Summary
An 82-year-old woman with a 60-year history of a lung tumor presented with hypoglycemia. Non-islet cell tumor hypoglycemia (NICTH) was suspected; however, her hypoglycemia stabilized with supplemental food. She was discharged, based on her wishes, and planned to undergo surgery later. After discharge, the hypoglycemia worsened rapidly and required immediate resection. Postoperatively, the hypoglycemia resolved. Western immunoblot analysis confirmed the presence of big insulin-like growth factor 2, confirming NICTH. This patient experienced the rapid progression of symptoms after an unprecedentedly long-term asymptomatic state. Therefore, when NICTH is suspected, early intervention is recommended regardless of the presence of asymptomatic state.

Learning points

In patients with NICTH, the onset of hypoglycemia is usually within a year of tumor detection, and few reports regarding long-term asymptomatic NICTH have been documented.

NICTH can cause rapidly progressive symptoms after a long-term asymptomatic state, as in this case, and an asymptomatic state does not preclude the necessity for intervention, especially when patients are at risk for malnutrition.

Tumor resection is the only curative treatment for patients with NICTH, but there is no consensus regarding the timing of surgery. However, considering the possibility of rapid symptom progression, patients should be examined and treated in a timely manner.
Insulinoma presenting with anti-insulin antibodies
Authors: Nakajima Rikako , Sato Daisuke , Togashi Ichirota , Idesawa Hiroto , Ito Jun , Ito Kei , Fujii Masanao , Yagyu Hiroaki 
Published: August 2024

Summary
An 89-year-old woman presented with a 6-year history of occasional episodes of impaired consciousness that were relieved by ingestion of a snack. Three months before presenting to our hospital, she had been hospitalized in a local hospital with subdural hematoma caused by a head contusion, where previously unrecognized hypoglycemia was discovered. Fasting plasma glucose concentration was 37 mg/dL, with a relatively high serum level of insulin (34.9 µU/mL). Computed tomography showed a 14 mm hyperenhancing tumor in the tail of the pancreas and she was referred to our hospital for further investigation. A prolonged fasting test revealed the plasma glucose concentration reduced to 43 mg/dL (2.4 mmol/L) at 8 h after the last meal. Serum insulin, proinsulin, and C-peptide concentrations were 21.1 µU/mL, 16.9 pmol/L, and 2.72 ng/mL, respectively. Subsequent intravenous administration of 1 mg of glucagon increased the plasma glucose concentration to 76 mg/dL (4.2 mmol/L). Moreover, the insulin-to-C-peptide molar ratio was 0.14. These data indicated the presence of insulinoma. Interestingly, serum anti-insulin antibodies were elevated (21.1 U/mL), although she had no history of taking exogenous insulin injection, alpha lipoic acid, or sulfhydryl group-containing agents. Human leukocyte antigen (HLA) typing revealed HLA-DRB1*0407 and HLA-DRB1*1405 alleles. Treatment with diazoxide prevented hypoglycemia, but was discontinued due to weight gain and leg edema. Elevated serum anti-insulin antibodies persisted almost 1 year after the diagnosis of insulinoma. We present a rare case of insulinoma concomitant with serum anti-insulin antibodies.

Learning points

Insulinoma presenting with concomitant anti-insulin antibodies appears rare.

Insulin/C-peptide molar ratio and serum insulin concentration are useful for differentiating insulinoma and autoimmune syndrome.

Flash glucose monitoring systems appear suitable for evaluating treatment outcomes.