bluuebunny/crossref_metadata_2025_split huggingface dataset:
Enhanced creative thinking under dopaminergic therapy in Parkinson disease
Authors: Faust‐Socher Achinoam , Kenett Yoed N. , Cohen Oren S. , Hassin‐Baer Sharon , Inzelberg Rivka 
Published: May 2014

ObjectiveCreative thinking requires a combination of originality, flexibility, and usefulness. Several reports described enhanced artistic creativity in Parkinson disease (PD) patients treated with dopaminergic agents. We aimed to examine PD patients' ability to perform creativity tasks compared to healthy controls and to verify whether creativity is related to an impulse control disorder (ICD) as a complication of dopaminergic therapy.MethodsRight‐handed PD patients treated with dopamine agonists and/or levodopa, and age‐ and education‐ matched neurologically healthy controls were assessed using the Montreal Cognitive Assessment, semantic verbal fluency, Beck Depression Inventory, and Questionnaire for Impulsive–Compulsive Disorders in Parkinson Disease Rating Scale (QUIP‐RS). Creativity assessment included Comprehension of Novel Metaphors (CNM), Remote Association Test, and Tel Aviv Creativity Test (TACT). Groups were compared using analyses of variance, t tests, and correlation analyses.ResultsTwenty‐seven PD patients (age, mean ± standard deviation = 62 ± 7 years; education = 16 ± 3 years; disease duration = 5.8 ± 3.9 years) and 27 controls (age = 59 ± 9 years; education 17 ± 3 years) participated. PD patients performed significantly better than controls in divergent thinking tasks; specifically, the TACT‐Visual for both fluency (33.48 ± 11.83 vs 25.59 ± 10.27, p = 0.034) and quality (15.78 ± 7.6 vs 11.19 ± 6.22, p = 0.025). Comprehension of Novel Metaphors was better in PD patients vs controls (0.71 ± 0.23 vs 0.55 ± 0.29, p = 0.04). QUIP‐RS scores did not correlate with creativity measures.InterpretationPD patients treated with dopaminergic drugs demonstrated enhanced verbal and visual creativity as compared to neurologically healthy controls. This feature was unrelated to ICD. Dopaminergic agents might act through the reduction of latent inhibition, resulting in widening of the associative network and enriched divergent thinking. Ann Neurol 2014;75:935–942
Arginine‐Containing Ligands Enhance H2 Oxidation Catalyst Performance
Authors: Dutta Arnab , Roberts John A. S. , Shaw Wendy J. 
Published: May 2014

AbstractHydrogenase enzymes use Ni and Fe to oxidize H2 at high turnover frequencies (TOF) (up to 10 000 s−1) and low overpotentials (<100 mV). In comparison, the fastest reported synthetic electrocatalyst, [NiII(PCy2NtBu2)2]2+, oxidizes H2 at 60 s−1 in MeCN under 1 atm H2 with an unoptimized overpotential of ca. 500 mV using triethylamine as a base.1 Here we show that a structured outer coordination sphere in a Ni electrocatalyst enhances H2 oxidation activity: [NiII(PCy2NArg2)2]8+ (Arg=arginine) has a TOF of 210 s−1 in water with high energy efficiency (180 mV overpotential) under 1 atm H2, and 144 000 s−1 (460 mV overpotential) under 133 atm H2. The complex is active from pH 0–14 and is faster at low pH, the most relevant condition for fuel cells. The arginine substituents increase TOF and may engage in an intramolecular guanidinium interaction that assists in H2 activation, while the COOH groups facilitate rapid proton movement. These results emphasize the critical role of features beyond the active site in achieving fast, efficient catalysis.
Enantioselective Copper‐Catalyzed Carboetherification of Unactivated Alkenes
Authors: Bovino Michael T. , Liwosz Timothy W. , Kendel Nicole E. , Miller Yan , Tyminska Nina , Zurek Eva , Chemler Sherry R. 
Published: May 2014

AbstractChiral saturated oxygen heterocycles are important components of bioactive compounds. Cyclization of alcohols onto pendant alkenes is a direct route to their synthesis, but few catalytic enantioselective methods enabling cyclization onto unactivated alkenes exist. Herein reported is a highly efficient copper‐catalyzed cyclization of γ‐unsaturated pentenols which terminates in CC bond formation, a net alkene carboetherification. Both intra‐ and intermolecular CC bond formations are demonstrated, thus yielding functionalized chiral tetrahydrofurans as well as fused‐ring and bridged‐ring oxabicyclic products. Transition‐state calculations support a cis‐oxycupration stereochemistry‐determining step.
Selective adsorption and degradation of rhodamine B with modified titanium dioxide photocatalyst
Authors: Bao Lanlan , Meng Minjia , Sun Kaiyong , Li Weibing , Zhao Dexiang , Li Huaming , He Minqiang 
Published: May 2014

ABSTRACTA new highly selective photocatalyst (RhB‐MIP/TiO2) was successfully prepared by surface molecular imprinting technique using rhodamine B (RhB) as template molecule. The adsorption kinetics show RhB‐MIP/TiO2 possessed fast adsorption rate, and adsorption behavior followed the pseudo‐second‐order kinetics. The static binding experiments revealed RhB‐MIP/TiO2 displayed strong affinity and high adsorption capacity for RhB. Moreover, the equilibrium adsorption rate of RhB‐MIP/TiO2 for RhB can be well fitted by the Langmuir isotherm model. The thermodynamics parameters indicated that the binding system of RhB‐MIP/TiO2 was endothermic and spontaneous. Compared with non‐imprinted photocatalyst (NIP/TiO2), RhB‐MIP/TiO2 exhibited excellent selectivity toward RhB, whose selectivity coefficient for RhB relative to rhodamine 6G (Rh6G) was 2.99. Selective photocatalytic degradation experiments indicated that the apparent rate constant for the photodegradation of RhB over RhB‐MIP/TiO2 is 0.0212 min−1, being 216% of that over NIP/TiO2 (0.0098 min−1). Therefore, RhB‐MIP/TiO2 exhibited higher photocatalytic selectivity toward RhB. The prepared photocatalyst RhB‐MIP/TiO2 has a promising perspective in industrial wastewater treatment. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40890.
Effect of low‐content carbon nanotubes on the dielectric and microwave absorption properties of graphite/polymer nanocomposites
Authors: Khurram A. A. , Rakha Sobia A. , Ali Naveed , Zhou Peiheng , Munir Arshad 
Published: May 2014

ABSTRACTHoneycomb cores (HCs) coated with graphite and multiwalled carbon nanotubes (MWCNTs) filled in a thermoplastic resin are proposed as microwave absorbers. The MWCNT contents varied from 0.2 to 0.6 wt % in a graphite‐filled (15 wt %) thermoplastic resin. The HCs were coated with three different types of coating materials for the sake of comparison: graphite, MWCNTs, and graphite plus MWCNTs. The dielectric properties [the real and imaginary parts of complex permittivity (ε′ and ε″, respectively)] and reflection loss (RL) of all of the coated HCs were measured and compared. We observed that the permittivities and RL increased significantly with increased weight percentage of the MWCNTs in the graphite‐filled thermoplastic resin. The RL measurements showed a maximum loss of −20 dB around 7 GHz and a bandwidth of 2.7 GHz at −10 dB in the HCs coated with the 0.4 wt % MWCNT plus graphite. There was also a shift in the RL peak position from the x band to the c band after the increase of MWCNT content. We also observed from the measurements that a combination of graphite and MWCNTs resulted in a broadband microwave absorber; a bandwidth of 13 GHz was observed for 80% RL when the MWCNT content increased to 0.6 wt % in the graphite‐incorporated resin. The possible mechanism that increased RL with the incorporation of MWCNTs in the graphite‐mixed thermoplastic resin is discussed. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40891.
High‐Tg, heat resistant epoxy–silica hybrids with a low content of silica generated by nonaqueous sol–gel process
Authors: Ponyrko Sergii , Kovářová Jana , Kobera Libor , Matějka Libor 
Published: May 2014

ABSTRACTThe epoxy‐silica hybrids showing high Tg and thermal stability are prepared by the non‐aqueous sol–gel process initiated with borontriflouride monoethylamine. Tetramethoxysilane (TMOS) is used as a precursor of silica and 3‐glycidyloxypropyl trimethoxysilane as a coupling agent to strengthen the interphase interaction with an epoxy matrix. The basic factors governing the nonaqueous sol–gel process are studied in order to reveal the formation–structure–properties relationships and to optimize the hybrid composition as well as conditions of the nonaqueous synthesis. The formation of the hybrid, its structure, thermomechanical properties and thermal stability are followed by chemorheology experiments, NMR, DMA and TGA. The most efficient reinforcement of the epoxy network is achieved by the combination of both alkoxysilanes, showing synergy effects. The hybrids with a low content (∼10 wt %) of the in situ generated silica exhibit dramatic increase in Tg and the high modulus, 335 MPa, up to the temperature 300°C. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40899.
Detection of the Grímsvötn 2011 volcanic eruption plumes using infrared satellite measurements
Authors: Cooke Michael C. , Francis Peter N. , Millington Sarah , Saunders Roger , Witham Claire 
Published: May 2014

AbstractInfrared satellite measurements were used to track the volcanic plume from Grímsvötn, Iceland in 2011. Following the explosive eruption, the plume was sheared by the atmosphere into two distinct volcanic clouds, one was ash‐rich and the other was mainly composed of sulphur dioxide (SO2) gas. Satellite retrievals of the volcanic ash were found to be consistent with an andesitic/basaltic composition, providing a framework for composition evaluation immediately following an eruption. SO2 was detectable for several weeks following the eruption highlighting the importance of monitoring volcanic clouds for a prolonged period to manage the associated risk of air traffic.
Quantification of homoegonol in rat plasma using liquid chromatography–tandem mass spectrometry and its pharmacokinetics application
Authors: Jeong Hyeon‐Uk , Kwon Soon Sang , Hwang Deok‐Gyu , Kim Eun Nam , Lee Kyeong , Ahn Kyung‐Seop , Oh Sei‐Ryang , Lee Hye Suk 
Published: May 2014

ABSTRACTHomoegonol is a biologically active neolignan isolated from Styrax species with cytotoxic, antimicrobial, anti‐inflammatory and anti‐asthma activities. For the quantification of homoegonol in rat plasma, a selective and sensitive liquid chromatography–tandem mass spectrometric method was developed and validated for the first time using protein precipitation with methanol as a sample clean‐up procedure. The analytes were separated in an Atlantis dC18 column using a gradient elution of methanol and 0.1% formic acid, and mass‐to‐charge ratios were determined in selective reaction monitoring mode using tandem mass spectrometry with m/z 343.12 > 296.97 for homoegonol and m/z 517.30 > 282.90 for udenafil (internal standard). The standard curve was linear over the concentration ranges of 1 − 500 ng/mL using a 30 μL rat plasma sample. The coefficient of variation and relative error for intra‐ and inter‐assay at four quality control levels were 3.9–10.0 and ‐3.3–2.7%, respectively. The overall recovery of homoegonol from rat plasma using protein precipitation was 99.7 ± 7.7%. The pharmacokinetics parameters of homoegonol were dose‐independent after both intravenous (1, 2.5 and 5 mg/kg doses) and oral (5, 10 and 20 mg/kg doses) administration in male Sprague–Dawley rats. Copyright © 2014 John Wiley & Sons, Ltd.
LC‐MS/MS determination of cinacalcet enantiomers in rat plasma on Chirobiotic V column in polar ionic mode: application to a pharmacokinetic study
Authors: Ramisetti Nageswara Rao , Bompelli Sravan 
Published: May 2014

ABSTRACTA simple and selective polar ionic liquid chromatography–tandem mass spectrometric method for separation and determination of cinacalcet enantiomers in rat plasma was developed and validated. The chromatographic separation was accomplished on a Chirobiotic V column packed with vancomycin as a chiral stationary phase using 2.5 mm ammonium formate in 100% methanol as a mobile phase in an isocratic mode of elution at a flow rate of 1.0 mL/min. The analytes were extracted from rat plasma by precipitating the proteins with acetonitrile. The developed method exhibited a linear dynamic range over 0.5–500 ng/mL in rat plasma for both enantiomers. The method was successfully applied to study the pharmacokinetics after a single dose by oral administration of 10 mg/kg of cinacalcet enantiomers to healthy male Wistar rats. Copyright © 2014 John Wiley & Sons, Ltd.
Recent applications and developments of capacitively coupled contactless conductivity detection (CE‐C4D) in capillary electrophoresis
Authors: Elbashir Abdalla A. , Aboul‐Enein Hassan Y. 
Published: May 2014

ABSTRACTCapacitively coupled contactless conductivity detection (C4D) has emerged as a powerful technique for the detection of compounds lacking any distinct chromophores or fluorophores. This review provides an update of the most recent application in CE‐C4D for pharmaceutical, biomedical and food covering the period from January 2012 to January 2014. The present review is an update of two previous review papers covering the years 2000–2010 (Biomedical Chromatography 2010; 24: 1038–1044 and Biomedical Chromatography 2012; 26: 990–1000). Representative examples illustrate the applicability of CE‐C4D in the fields of pharmaceutical, biomedical and food. Finally, general conclusions and perspectives are provided. Copyright © 2014 John Wiley & Sons, Ltd.
Chirality and Chiroptical Properties of Amyloid Fibrils
Authors: Dzwolak Wojciech 
Published: May 2014

ABSTRACTChirality of amyloid fibrils‐linear beta‐sheet‐rich aggregates of misfolded protein chains‐often manifests in morphological traits such as helical twist visible in atomic force microscopy and in chiroptical properties accessible to vibrational circular dichroism (VCD). According to recent studies the relationship between molecular chirality of polypeptide building blocks and superstructural chirality of amyloid fibrils may be more intricate and less deterministic than previously assumed. Several puzzling experimental findings have put into question earlier intuitive ideas on: 1) the bottom‐up chirality transfer upon amyloidogenic self‐assembly, and 2) the structural origins of chiroptical properties of protein aggregates. For example, removal of a single amino acid residue from an amyloidogenic all‐L peptide was shown to reverse handedness of fibrils. On the other hand, certain types of amyloid aggregates revealed surprisingly strong VCD spectra with the sign and shape dependent on the conditions of fibrillation. Hence, microscopic and chiroptical studies have highlighted chirality as one more aspect of polymorphism of amyloid fibrils. This brief review is intended to outline the current state of research on amyloid‐like fibrils from the perspective of their structural and superstructural chirality and chiroptical properties. Chirality 26:580–587, 2014. © 2014 Wiley Periodicals, Inc.
Highly Sensitive Ratiometric Chemosensor for Selective ′Naked‐Eye′ Nanomolar Detection of Co2+ in Semi‐Aqueous Media
Authors: Patil Smita , Fegade Umesh , Sahoo Suban K. , Singh Amanpreet , Marek Jaromir , Singh Narinder , Bendre Ratnamala , Kuwar Anil 
Published: May 2014

AbstractAn easy‐to‐prepare chemosensor, (E)‐1‐(phthalazine‐4‐yl)‐2‐(1‐(pyridine‐2‐yl)ethylidene) hydrazine (3), structurally characterized by single X‐ray crystallography, is developed for the selective and sensitive detection of Co2+ in aqueous media. Chemosensor 3 shows both absorption and fluorescence responses to Co2+ by forming a 1:1 complex (among the surveyed metal ions) with a detection limit down to 50 nM. It can also be used as a ′naked‐eye′ sensor due to the outstanding visible and emission color changes from yellow to red and blue to orange, respectively.
Efficacy of real‐time continuous glucose monitoring on glycaemic control and glucose variability in type 1 diabetic patients treated with either insulin pumps or multiple insulin injection therapy: a randomized controlled crossover trial
Authors: Tumminia Andrea , Crimi Salvatore , Sciacca Laura , Buscema Massimo , Frittitta Lucia , Squatrito Sebastiano , Vigneri Riccardo , Tomaselli Letizia 
Published: May 2014

AbstractBackgroundThe aim of this study was to determine the efficacy of real‐time continuous glucose monitoring in T1D patients treated with insulin pump therapy or multiple daily insulin therapy.MethodsTwenty adult patients (ten insulin pump therapy and ten multiple daily insulin) with poor glycaemic control (HbA1c > 8.0%) were randomized into two groups for 6 months: the continuous glucose monitoring arm (using real‐time continuous glucose monitoring) and the SMBG arm. After 2 months of wash‐out, the participants crossed over. The primary outcome was HbA1c reduction. The secondary outcomes were hypoglycaemia and hyperglycaemia risk assessment (area under the curve < 70 mg/dL/day and AUC > 200 mg/dL/day, respectively) and glucose variability.ResultsFourteen patients (eight multiple daily insulin, six insulin pump therapy) used continuous glucose monitoring appropriately (at least 40% of the time). In these patients, the improvement in glycaemic control was more evident during the real‐time continuous glucose monitoring period (7.76% ± 0.4 vs 8.54% ± 0.4, p < 0.05) than during the self‐monitoring of blood glucose period (8.42% ± 0.4 vs 8.56% ± 0.5, p = 0.2). Better results with continuous glucose monitoring were observed in patients using multiple daily insulin with greater improvement in both glycaemic control (7.71% ± 0.2 vs 8.58% ± 0.2, p < 0.05) and glucose variability and with a marked reduction in the risk of both hypoglycaemia and hyperglycaemia.ConclusionsAppropriate use of real‐time continuous glucose monitoring improved glycometabolic control in T1D patients. The effects of continuous glucose monitoring were more evident in patients under multiple daily insulin treatment, compared with insulin pump therapy. Glucose variability, in addition to glycaemic control, was improved in compliant diabetic patients. Copyright © 2014 John Wiley & Sons, Ltd.
Constitutive notch signaling in adult transgenic mice inhibits bFGF‐induced angiogenesis and blocks ovarian follicle development
Authors: Liu Ju , Deutsch Urban , Jeong James , Lobe Corrinne G. 
Published: May 2014

SummaryNotch signaling is important in angiogenesis during embryonic development. However, the embryonic lethal phenotypes of knock‐out and transgenic mice have precluded studies of the role of Notch post‐natally. To develop a mouse model that would bypass the embryonic lethal phenotype and investigate the possible role of Notch signaling in adult vessel growth, we developed transgenic mice with Cre‐conditional expression of the constitutively active intracellular domain of Notch1 (IC‐Notch1). Double transgenic IC‐Notch1/Tie2‐Cre embryos with endothelial specific IC‐Notch1 expression died at embryonic day 9.5. They displayed collapsed and leaky blood vessels and defects in angiogenesis development. A tetracycline‐inducible system was used to express Cre recombinase postnatally in endothelial cells. In adult mice, IC‐Notch1 expression inhibited bFGF‐induced neovascularization and female mice lacked mature ovarian follicles, which may reflect the block in bFGF‐induced angiogenesis required for follicle growth. Our results demonstrate that Notch signaling is important for both embryonic and adult angiogenesis and indicate that the Notch signaling pathway may be a useful target for angiogenic therapies. genesis 52:809–816, 2014. © 2014 Wiley Periodicals, Inc.
Pollinators visit related plant species across 29 plant–pollinator networks
Authors: Vamosi Jana C. , Moray Clea M. , Garcha Navdeep K. , Chamberlain Scott A. , Mooers Arne Ø. 
Published: May 2014

AbstractUnderstanding the evolution of specialization in host plant use by pollinators is often complicated by variability in the ecological context of specialization. Flowering communities offer their pollinators varying numbers and proportions of floral resources, and the uniformity observed in these floral resources is, to some degree, due to shared ancestry. Here, we find that pollinators visit related plant species more so than expected by chance throughout 29 plant–pollinator networks of varying sizes, with “clade specialization” increasing with community size. As predicted, less versatile pollinators showed more clade specialization overall. We then asked whether this clade specialization varied with the ratio of pollinator species to plant species such that pollinators were changing their behavior when there was increased competition (and presumably a forced narrowing of the realized niche) by examining pollinators that were present in at least three of the networks. Surprisingly, we found little evidence that variation in clade specialization is caused by pollinator species changing their behavior in different community contexts, suggesting that clade specialization is observed when pollinators are either restricted in their floral choices due to morphological constraints or innate preferences. The resulting pollinator sharing between closely related plant species could result in selection for greater pollinator specialization.
Multiple paternity is a shared reproductive strategy in the live‐bearing surfperches (Embiotocidae) that may be associated with female fitness
Authors: LaBrecque John R. , Alva‐Campbell Yvette R. , Archambeault Sophie , Crow Karen D. 
Published: May 2014

AbstractAccording to Bateman's principle, female fecundity is limited relative to males, setting the expectation that males should be promiscuous, while females should be choosy and select fewer mates. However, several surfperches (Embiotocidae) exhibit multiple paternity within broods indicating that females mate with multiple males throughout the mating season. Previous studies found no correlation between mating success and reproductive success (i.e., a Bateman gradient). However, by including samples from a broader range of reproductive size classes, we found evidence of a Bateman gradient in two surfperch species from distinct embiotocid clades. Using microsatellite analyses, we found that 100% of the spotfin surfperch families sampled exhibit multiple paternity (Hyperprosopon anale, the basal taxon from the only clade that has not previously been investigated) indicating that this tactic is a shared reproductive strategy among surfperches. Further, we detected evidence for a Bateman gradient in H. anale; however, this result was not significant after correction for biases. Similarly, we found evidence for multiple paternity in 83% of the shiner surfperch families (Cymatogaster aggregata) sampled. When we combine these data with a previous study on the same species, representing a larger range of reproductive size classes and associated brood sizes, we detect a Bateman gradient in shiner surfperch for the first time that remains significant after several conservative tests for bias correction. These results indicate that sexual selection is likely complex in this system, with the potential for conflicting optima between sexes, and imply a positive shift in fertility (i.e., increasing number) and reproductive tactic with respect to the mating system and number of sires throughout the reproductive life history of females. We argue that the complex reproductive natural history of surfperches is characterized by several traits that may be associated with cryptic female choice, including protracted oogenesis, uterine sac complexity, and sperm storage.