bluuebunny/crossref_metadata_2025_split huggingface dataset:
Excessive smartphone use increases self-reported auditory and vestibular symptoms
Authors: Söylemez Emre , Dağ Mehmet , Ilgaz Abdulkadir , Korkmaz Bekir , Topçuoğlu Ümit , Koç Ahmet Düha , Ensari Serdar 
Published: August 2024

Summary
Background
With widespread smartphone use, there is growing concern about their potential impact on human health.

Objective
The effects of smartphone use on self-reported hearing ability, tinnitus, balance, falls, and anxiety level were investigated in this study.

Methods
This study included 682 participants who were divided into 2 groups: a high smartphone use (HSU) group and a low smartphone use (LSU) group. Both groups were evaluated for hearing ability using the Amsterdam inventory for auditory disability and handicap; balance status using the vertigo, dizziness, imbalance symptom scale; anxiety status using the Beck anxiety index; and fall and tinnitus status using the visual analog scale.

Results
The HSU group showed significantly worse hearing ability, tinnitus, balance, falling, and anxiety status results than the LSU group (p < 0.001). There was a positive correlation between smartphone addiction severity and auditory impairment, tinnitus, risk of falling, and anxiety, as well as a negative correlation with balance score (p < 0.001).

Conclusion
The findings suggest that individuals with excessive smartphone use are more likely to experience hearing, tinnitus, balance, falling, and anxiety problems than those who use smartphones less frequently. Excessive smartphone use may be considered a potential risk factor for these problems.
A new approach in insulin pump education improves glycemic outcomes: a randomized controlled trial
Authors: Rytter Karen , Hougaard Anette , Skouboe Anne Grynnerup , Serifovski Nermin , Ranjan Ajenthen Gayathri , Nørgaard Kirsten 
Published: August 2024

Abstract

Aims
To address the scarcity of continued education for insulin pump users, we developed and evaluated a new program (NP) for individuals transitioning to a different insulin pump.

Methods
In a randomized, controlled 3-month study, adults with type 1 diabetes and suboptimal HbA1c received either NP or usual care program (UC). The NP was designed in collaboration with representatives of the target group and incorporated technical training, case-based learning, and peer experience sharing – encompassing two group sessions, and two follow-up telephone calls. The UC included a single training session led by the pump company with hotline assistance (clinic) but no structured follow-up. The primary endpoint was the difference in time in range (TIR) (70–180 mg/dL (3.9–10.0 mmol/L)), measured by continuous glucose monitoring from baseline to 3 months post-course. Psychosocial self-efficacy was measured by the Diabetes Empowerment Scale (DES-SF).

Results
Thirty-nine participants (median age 43, 74% female) were included. Mean TIR increased significantly in the NP group and remained unchanged in the UC group (between-group difference in change was 13.5% [95% CI: 4.0 to 22.9], p = 0.0064). Psychosocial self-efficacy improved and HbA1c decreased only significantly in the NP group.

Conclusions
Applying a novel education program at pump transition significantly improved glycemic outcomes and self-efficacy.
Thunderstorm climatology of Slovakia between 1984–2023
Authors: Vido Jaroslav , Borsányi Peter , Nalevanková Paulína , Hanzelová Miriam , Kučera Jiří , Škvarenina Jaroslav 
Published: August 2024

AbstractThunderstorms are among the most extreme meteorological phenomena that can cause widespread destruction and loss of life. Their occurrence varies significantly across different regions and times of the year. Despite various studies on thunderstorm activity across Central Europe, direct analyses based on data from the Slovak territory still need to be made available. Given Slovakia’s diverse natural conditions, there is a need for detailed knowledge about the frequency and spatial distribution of thunderstorms in this region. To address this knowledge gap, we analysed the frequency and spatiotemporal distribution of days with thunderstorm occurrences in Slovakia between 1984 and 2023, utilising climatological data from the Slovak Hydrometeorological Institute. We limited our analysis to data of days with close thunderstorms (thunderstorms occurring within 3 km of the monitoring station). Our findings reveal a significant variation in thunderstorm occurrences across Slovakia, with peak activity in the summer, especially in June and July. However, the spatial distribution of thunderstorms differed significantly across the country, with the highest frequency observed in mountainous regions and the east-central part of Slovakia. We found significant deceasing signals of the thunderstorm activity trends during the studied period, including analyses during the colder part of the year. Furthermore, our results underscore the critical role of synoptic situations in shaping these trends, where changes in certain atmospheric patterns were closely aligned with variations in thunderstorm frequency. The interaction between these synoptic conditions and regional topography was particularly evident, reinforcing the notion that topographical and environmental complexities substantially contribute to the observed thunderstorm distribution.
The role of postoperative blood pressure management in early postoperative hemorrhage in awake craniotomy glioma patients
Authors: Demetz Matthias , Krigers Aleksandrs , Uribe-Pacheco Rodrigo , Pinggera Daniel , Klingenschmid Julia , Thomé Claudius , Freyschlag Christian F. , Kerschbaumer Johannes 
Published: August 2024

AbstractPostoperative hemorrhage can severely affect the patients’ neurological outcome after awake craniotomy. Higher postoperative blood pressure can increase the risk of postoperative hemorrhage. The aim of this study was to investigate the role of postoperative blood pressure and other common radiological and epidemiological features with the incidence of postoperative hemorrhage. In this retrospective analysis, we included patients who underwent awake surgery at our institution. We assessed the blood pressure both intra- and postoperatively as well as the heart rate for the first 12 h. We compared a cohort with postoperative hemorrhage, who required further treatment (surgical revision or intravenous antihypertensive therapy), with a cohort with no postoperative hemorrhage. We included 48 patients with a median age of 39 years. 9 patients (19%) required further treatment due to postoperative hemorrhage, which was surgery in 2 cases and intensive blood pressure measurements in 7 cases. However, with early treatment, no significant difference in Performance scores at follow-up could be found. Patients with postoperative hemorrhage showed significantly higher postoperative systolic blood pressure during the hours 3–12 (p < 0.05) as well as intraoperatively throughout the procedure (p < 0.05). In ROC and Youden Test, a strong impact of systolic blood pressure over 140mmHg during the early postoperative course could be shown. Postoperative hemorrhage is a rare but possible complication in awake surgery glioma patients. To avoid postoperative hemorrhage, treating physicians should aim strictly on systolic blood pressure of under 140mmHg for the postoperative course.
Guiding the implementation of data privacy with microservices
Authors: Antunes Pedro , Guimarães Nuno 
Published: August 2024

AbstractPrivacy by design is nowadays recognized as essential in bringing data privacy into software systems. However, developers still face many challenges in reconciling privacy and software requirements and implementing privacy protections in software systems. One emerging trend is the adoption of microservices architectures—they bring in some qualities that can benefit privacy by design. The main goal of this study is to adapt privacy by design to the qualities brought by microservices. The main focus is at the architectural level, where the main structural decisions are made. A systematic literature review is adopted to identify a set of privacy models that underscore significant differences in software systems’ protection using microservices. From the literature review, a decision framework is developed. The decision framework provides guidance and supports design decisions in implementing data privacy using microservices. The framework helps select and integrate different privacy models. An illustration of using the framework, which considers the design of an electronic voting system, is provided. This study contributes to closing the gap between regulation and implementation through design, where decisions related to data privacy are integrated with decisions on architecting systems using microservices.
RBPMN: the value of roles for business process modeling
Authors: Skouti Tarek , Seiger Ronny , Furrer Frank J. , Strahringer Susanne 
Published: August 2024

AbstractBusiness process modeling is essential for organizations to comprehend, analyze, and enhance their business operations. The business process model and notation (BPMN) is a standard widely adopted for illustrating business processes. However, it falls short when modeling roles, interactions, and responsibilities within complex modern processes that involve digital, human, and non-human entities, typically found in cyber-physical systems (CPS). In this paper, we introduce Role-based BPMN (RBPMN), a standard-compliant extension of BPMN 2.0 that distinctly depicts roles and their interactions within business processes. We underscore the value of RBPMN and a role-based context modeling approach through a modeling example in CPS that facilitates the representation of role-based variations in the process flow, namely a production process in a smart factory. Our findings suggest that RBPMN is a valuable BPMN extension that enhances the expressiveness, variability, and comprehensiveness of business process models, especially in complex and context-sensitive processes.
Satellite-derived measures of habitat structure perform as well as locally recorded measures in predicting predation on artificial nests in central European agricultural landscapes
Authors: Morris Shane D. , Bosseler Larissa , Selimovic Aldin , Bieber Claudia 
Published: August 2024

AbstractGround nesting birds have declined throughout Europe, with the reduction of habitat structure in agricultural areas being a key contributing factor. Habitat structure is vital not only for providing food and suitable microclimates for these species but also limits nest predation. Field assessments of habitat structure have, historically, been the most common way of identifying areas of low nest predation. However, they are limited in their applicability over wide areas due to time, money, and logistics. Remotely sensed measures (e.g., recorded by a satellite) can address these issues. Normalised difference vegetation index (NDVI) is a measure of the ‘greenness’ of an area and correlates with habitat structure. We conducted an artificial nest experiment over three years (2019, 2020, 2023) in Baden, Austria to test the relationship of NDVI to nest predation in an agricultural landscape. Critically, we compared whether NDVI could predict nest predation as well as locally recorded variables (ground cover, vegetation height, etc, ). We report that NDVI performs equally well at predicting nest predation, with predation decreasing with higher values of NDVI, signifying greater habitat structure. This was supported by our finding that predation probability decreased with greater ground cover (a locally recorded variable). Additionally, we found that areas with greater partridge numbers had higher predation and circumstantial evidence that birds are the primary predator in our study area. Overall, our study shows that satellite-derived measures of habitat structure have untapped potential in identifying areas of high nest predation for European ground nesting birds in agricultural landscapes.
Evaluating EHR-Integrated Digital Technologies for Medication-Related Outcomes and Health Equity in Hospitalised Adults: A Scoping Review
Authors: Murthi Sreyon , Martini Nataly , Falconer Nazanin , Scahill Shane 
Published: August 2024

Abstract
The purpose of this scoping review is to identify and evaluate studies that examine the effectiveness and implementation strategies of Electronic Health Record (EHR)-integrated digital technologies aimed at improving medication-related outcomes and promoting health equity among hospitalised adults. Using the Consolidated Framework for Implementation Research (CFIR), the implementation methods and outcomes of the studies were evaluated, as was the assessment of methodological quality and risk of bias. Searches through Medline, Embase, Web of Science, and CINAHL Plus yielded 23 relevant studies from 1,232 abstracts, spanning 11 countries and from 2008 to 2022, with varied research designs. Integrated digital tools such as alert systems, clinical decision support systems, predictive analytics, risk assessment, and real-time screening and surveillance within EHRs demonstrated potential in reducing medication errors, adverse events, and inappropriate medication use, particularly in older patients. Challenges include alert fatigue, clinician acceptance, workflow integration, cost, data integrity, interoperability, and the potential for algorithmic bias, with a call for long-term and ongoing monitoring of patient safety and health equity outcomes. This review, guided by the CFIR framework, highlights the importance of designing health technology based on evidence and user-centred practices. Quality assessments identified eligibility and representativeness issues that affected the reliability and generalisability of the findings. This review also highlights a critical research gap on whether EHR-integrated digital tools can address or worsen health inequities among hospitalised patients. Recognising the growing role of Artificial Intelligence (AI) and Machine Learning (ML), this review calls for further research on its influence on medication management and health equity through integration of EHR and digital technology.
Inbound friend or foe: how motion bistability is resolved under threat
Authors: Silva Fábio , Magalhães Ana C. , Fidalgo Daniela , Gomes Nuno , Garrido Marta I. , Soares Sandra C. 
Published: August 2024

AbstractAnxiety prepares us to deal with unpredictable threats, such as the approaching of an unknown person. Studies have shown our innate tendency to see approaching motion in ambiguous walkers in what was termed facing-the-viewer (FTV) bias. Here we investigated if anxiety states further contributed to this bias, hypothesizing that such states would increase overall FTV biases. Throughout three Experiments, we asked participants to judge the motion direction of ambiguous point-light walkers and measured their respective FTV biases under safe and anxiety-related conditions induced via imagery (Experiment 1), screaming sounds (Experiment 2), and threat of shock (Experiment 3). Across all experiments, we showed that anxiety does not affect our tendency to perceive an approaching behavior in ambiguous walkers. Based on our findings, and the discrepancies found in the literature, we emphasize the need for future studies to paint a clearer picture on the nature and aspects capable of affecting this bias.
Optimizing recovery strategies for winter athletes: insights for Milano-Cortina 2026 Olympic Games
Authors: Edholm Peter , Ørtenblad Niels , Holmberg Hans-Christer , Sperlich Billy 
Published: August 2024

Abstract
Purpose
This narrative umbrella review evaluates the efficacy of recovery strategies for elite winter sports athletes by comparing their scientific and clinical validity. It aims to provide evidence-based recommendations for coaches and athletes, preparing them for the Milano-Cortina 2026 Olympic Games through a critical evaluation of various post-training and competition recovery methods.

Methods
This narrative umbrella review involved a systematic literature search on PubMed, focusing on recent meta-analyses and review articles related to recovery strategies. Special emphasis was placed on their practical applications to ensure the findings are relevant to real-world settings.

Results
The study examined multiple recovery strategies, including sleep, nutrition, and physical methods, revealing a general scarcity of high-quality studies and insufficient control over placebo effects. A key finding emphasizes the crucial roles of nutrition and sleep in the recovery process, highlighting the need for personalized recovery plans tailored to the athlete's and sport's specific demands. The effectiveness of physical recovery methods varied, with some demonstrating significant benefits in specific contexts (e.g., massage and cold-water immersion to alleviate muscle pain and fatigue), whereas others (e.g., stretching and sauna) lacked robust evidence of their efficacy as recovery methods.

Conclusion
This paper presents recommendations for optimizing recovery strategies in elite winter sports, focusing on the specific demands of the Milano-Cortina 2026 Olympic Games. It provides a framework for athletes and coaches aiming to enhance performance recovery and achieve optimal athletic condition.
Disparities and Medical Expenditure Implications in Pediatric Tele-Mental Health Services During the COVID-19 Pandemic in Mississippi
Authors: Zhang Yunxi , Lal Lincy S. , Lin Yueh-Yun , Swint J. Michael , Zhang Ying , Summers Richard L. , Jones Barbara F. , Chandra Saurabh , Ladner Mark E. 
Published: August 2024

AbstractTele-mental health (TMH) services, including both mental and behavioral healthcare (MBH) services, emerged as a cornerstone in delivering pediatric mental healthcare during the coronavirus disease 2019 (COVID-19) pandemic, yet their utilization and effects on healthcare resource utilization (HCRU) and medical expenditures remain unclear. To bridge the gap, this study aims to investigate the association between TMH utilization and sociodemographic factors and assess its associated HCRU and medical expenditures within a pediatric population in Mississippi. Studying 1,972 insured pediatric patients who accessed outpatient MBH services at the study institution between January 2020 and June 2023, age, race, insurance type, rural residency, and household income were identified as key determinants of TMH utilization. Adjusting for sociodemographics, TMH utilization was associated with 122% more MBH-associated outpatient visits and 36% higher related medical expenditures, but 27% less overall medical expenditures. This study reveals sociodemographic disparities in pediatric TMH utilization, highlights its role in augmenting outpatient mental healthcare access, and shows its potential for cost savings. Future efforts should aim at fostering more digitally inclusive, equitable, and affordable pediatric mental healthcare services.
Fachfremder Vertretungsunterricht von Lehramtsstudierenden – Eine Bestandsaufnahme in Niedersachsen
Authors: Winter Isabelle , Kaiser Till , Nonte Sonja , Bellenberg Gabriele , Reintjes Christian 
Published: August 2024

ZusammenfassungIm Kontext der akuten Herausforderung des Lehrkräftemangels manifestiert sich an Schulen vermehrt der Einsatz von Lehramtsstudierenden zur Deckung des Bedarfs (SWK 2023a). Aus dem Mangel resultiert zudem, dass Lehrkräfte fachfremd unterrichten. Der vorliegende Beitrag offeriert auf Grundlage einer explorativen, querschnittlichen Studie einen erstmaligen und nuancierten Einblick in die Tätigkeit von Studierenden an Schulen in Niedersachsen hinsichtlich ihres Einsatzes im fachfremden Unterricht. Die Daten wurden im Rahmen einer freiwilligen Online-Befragung im Wintersemester 2022/2023 an sechs Hochschulen/Universitäten in Niedersachsen erhoben. Aufbauend auf einer umfassenden Bestandsaufnahme einschlägiger (inter-)nationaler empirischer Befunde zum fachfremden Unterrichten sowie Unterrichten neben dem Studium erfolgt die Formulierung von Forschungsfragen sowie eine Darlegung des angewandten Studiendesigns. Nach der Präsentation ausgewählter Befunde zum fachfremden Unterrichten durch studentische Vertretungslehrkräfte schließt der Beitrag mit einer Diskussion der resultierenden Implikationen.
2-methoxyestradiol sensitizes tamoxifen-resistant MCF-7 breast cancer cells via downregulating HIF-1α
Authors: Attia Yasmin M. , Mokhlis Hamada Ahmed , Ismail Ahmed , Doghish Ahmed S. , Sobhy Mohamed H. , Hassanein Sherif S. , El-Dakroury Walaa A. , Mariee Amr D. , Salama Salama A. , Sharaky Marwa 
Published: August 2024

AbstractThe clinical studies for breast cancer (BC) are now assessing the efficacy of 2-Methoxyestradiol (2-ME), a naturally occurring derivative of estradiol. Our study aimed to explore the potential of combining the 2-ME and tamoxifen (TAM) on sensitization of TAM-resistant cells using LCC2 the TAM-resistant cells as a model and comparing the results to the sensitive cells MCF-7. Sulphorhodamine-B (SRB) assay is used to examine the 2-ME chemo-sensitizing impact on the cytotoxicity of TAM on LCC2 cells. Colorimetric assay kits were used to assess the level of the apoptosis-related markers caspases 3, Bcl2, and Bax in cell lysate. Hypoxia-inducible factor 1 alpha (HIF-1α) expression was measured using western blotting. Total cholesterol and triglyceride (TG) levels were examined colorimetrically, using the BIOLABO kit. The use of 2-ME enhanced the cytotoxic effects of TAM and effectively reversed TAM resistance. This was achieved by inhibiting the expression of HIF-1α, while concurrently increasing the levels of apoptotic marker caspase-3, as well as the pro-apoptotic protein Bax. Additionally, there was a reduction in the levels of Bcl2, an anti-apoptotic protein. Furthermore, a reduction in TG and cholesterol levels was noted. Our findings show that HIF-1α plays an important role in TAM resistance and that suppression of HIF-1α by 2-ME-mediated sensitization of BC-resistant cells to TAM. Therefore, the concurrent administration of TAM/2-ME might potentially serve as a viable therapeutic approach to address TAM resistance and enhance the overall therapy efficacy for patients with BC.
Analyzing the implementation of predictive control systems and application of stored data in non-residential buildings
Authors: Savadkoohi Marjan , Macarulla Marcel , Tejedor Blanca , Casals Miquel 
Published: August 2024

AbstractIn non-residential buildings, building energy management systems (BEMS) and the application of data hold significant promise in reducing energy consumption. Nevertheless, BEMS have different levels of complexity, benefit, and limitation. Despite the advanced technologies and improvements in building operation, there is a clear gap in the actual performance of buildings that has been attributed to the adoption of advanced technologies. Consequently, there is an increasing need for researchers and practitioners to study current practices in order to identify and address the challenges that compromise the core objectives of BEMS. For this reason, this paper aims to validate three research questions: (i) to examine the current state of BEMS and its functionalities; (ii) to analyze the type of control used; (iii) and to determine the availability of historical data compiled by BEMS and its application in non-residential buildings. A survey of 676 buildings and interviews with building professionals were conducted. The findings confirmed that most of the buildings applied BEMS with scheduled control. In addition, a lack of digitized data for analysis and predictions was detected. Indeed, only 0.60% of the investigated buildings implemented predictive control. Finally, using hierarchical clustering analysis, responses were grouped to analyze similarities between them. The study findings help to develop targeted actions for implementing predictive control in non-residential buildings.