bluuebunny/crossref_metadata_2025_split huggingface dataset:
Cognitive-behavioral treatment for insomnia and mindfulness-based stress reduction in nurses with insomnia: a non-inferiority internet delivered randomized controlled trial
Authors: Guo Wanran , Nazari Nabi , Sadeghi Masoud 
Published: July 2024

Background
Insomnia is a highly prevalent sleep disorder frequently comorbid with mental health conditions in nurses. Despite the effectiveness of evidence-based cognitive behavioral therapy for insomnia (CBT-I), there is a critical need for alternative approaches. This study investigated whether internet-delivered mindfulness-based stress reduction (IMBSR) for insomnia could be an alternative to internet-delivered CBT-I (ICBT-I).

Objective
The hypothesis was that the IMBSR would be noninferior to the ICBT-I in reducing the severity of insomnia among nurses with insomnia. Additionally, it was expected that ICBT-I would produce a greater reduction in the severity of insomnia and depression than IMBSR.

Method
Among 240 screened nurses, 134 with insomnia were randomly allocated (IMBSR, n = 67; ICBT-I, n = 67). The assessment protocol comprised clinical interviews and self-reported outcome measures, including the Insomnia Severity Index (ISI), Patient Health Questionnaire-9 (PHQ-9), the 15-item Five Facet Mindfulness Questionnaire (FFMQ), and the Client Satisfaction Questionnaire (CSQ-I).

Results
The retention rate was 55% with 77.6% (n = 104) of participants completing the study. At post-intervention, the noninferiority analysis of the ISI score showed that the upper limit of the 95% confidence interval was 4.88 (P = 0.46), surpassing the pre-specified noninferiority margin of 4 points. Analysis of covariance revealed that the ICBT-I group had significantly lower ISI (Cohen’s d = 1.37) and PHQ-9 (Cohen’s d = 0.71) scores than did the IMBSR group. In contrast, the IMBSR group showed a statistically significant increase in the FFMQ-15 score (Cohen’s d = 0.67). Within-group differences showed that both the IMBSR and ICBT-I were effective at reducing insomnia severity and depression severity and improving mindfulness.

Conclusion
Overall, nurses demonstrated high levels of satisfaction and adherence to both interventions. The IMBSR significantly reduced insomnia severity and depression, but the findings of this study do not provide strong evidence that the IMBSR is at least as effective as the ICBT-I in reducing insomnia symptoms among nurses with insomnia. The ICBT-I was found to be significantly superior to the IMBSR in reducing insomnia severity, making it a recommended treatment option for nurses with insomnia.
Evaluation of the facial profile of skeletal Class III patients undergoing camouflage orthodontic treatment: a retrospective study
Authors: Li Xiaobei , Tian Yuan , Guo Runzhi , Li Weiran , He Danqing , Sun Yannan 
Published: July 2024

Objective
To identify objective metrics for evaluating the esthetics of facial profiles in skeletal Class III patients undergoing camouflage orthodontic treatment.

Methods
Eighty Asian–Chinese patients classified as skeletal Class III were included. Thirty cephalometric measurements of pre- and posttreatment cephalograms were analyzed. Ten orthodontists assigned visual analog scale (VAS) scores to the pre- and posttreatment profiles based on standardized lateral photographs. Correlations between subjective VAS scores and objective measurements were assessed using Pearson correlation and stepwise multiple linear regression analysis.

Results
Lower incisor (L1) protrusion, nasolabial angle, lower lip-E line distance, SNB angle, and L1 to AP plane were significantly correlated with VAS scores of pretreatment profiles of skeletal Class III patients. Factors such as retraction of the lower incisor, increased interincisal angle and overjet, reduction of lower lip-E line distance, as well as augmentation of the Z angle and nasolabial angle were significantly correlated with the changes in VAS scores post-camouflage orthodontic treatment. Stepwise multiple linear regression analysis revealed that pretreatment nasolabial angle, changes in the lower lip-E line distance, and pretreatment Pog-NB distance were the key factors influencing the posttreatment facial profile esthetics of skeletal Class III patients with camouflage orthodontic treatment.

Conclusion
Several cephalometric measurements correlate with subjective facial esthetic evaluations of skeletal Class III patients. Changes in lower lip prominence, the pretreatment nasolabial angle, and Pog-NB distance are the main factors related to facial esthetics in skeletal Class III patients after camouflage orthodontic treatment.
Optimization of Foliar Nutrition and Nipping for Quality of Pigeonpea [Cajanus cajan (L). Millsp.]
Authors: Kaggod Anuradha , Prasad S. Rajendra , Ramanappa T. M. , Thimmegowda M. N. , Parashivamurty  , Mudalagiriyappa  
Published: July 2024

A field experiment was conducted in red sandy clay loam soil at UAS, GKVK, Bengaluru during kharif to know the influence of foliar nutrition and nipping on crop growth, seed yield and quality in pigeonpea. The experiment replicated six times in split plot design with treatments of foliar spray of water soluble fertilizer (WSF)with three different concentration F0 (100% RDF), F1 (75% RDF + 25% WSF (19: 19:19), F2 (75% RDF + 12.5% WSF (19: 19:19) in combination with nipping (N1) and no nipping (N0). The results revealed that seed quality parameters viz.,germination (85.75 %) mean seedling length (48.28 cm), mean seedling dry weight (47.33 mg), seedling vigour index-I (4137), seedling vigour index -II (4112), lower electrical conductivity (1.07 mS ppt-1), total dehydrogenase activity (3.30 A480nm) and total soluble protein (23.19%) recorded higher in F2N1 (75% RDF + 12.5% WSF (19: 19:19) + nipping) over control (81.42%, 44.59 cm, 41.67 mg seedling-1, 3724, 3346, 1.44 mS ppt-1, 2.22 A480nm, 20.22 %,) respectively.
An Aggregation‐Induced Emission Luminogen with Efficient Luminescent Mechanochromism and Optical Waveguiding Properties
Authors: Zhao Na , Zhang Chuang , Lam Jacky W. Y. , Zhao Yong Sheng , Tang Ben Zhong 
Published: December 2013

AbstractIn this study, a yellow luminogen (TPE‐DCV) was synthesized by treating tetraphenylethene with two dicyanovinyl units. TPE‐DCV is non‐emissive in solution but becomes a strong emitter when aggregated in poor solvents or in the solid state, thereby displaying a phenomenon of aggregation‐induced emission. The solid‐state emission of TPE‐DCV can be reversibly switched between green and yellow with a moderate contrast ratio by grinding and fuming or heating processes owing to the morphological change between thermodynamically stable crystalline phase and the metastable amorphous state and vice versa. Negligible reabsorption and well‐ordered molecular arrangement of the microcrystals of TPE‐DCV make them promising as optical waveguide materials with low optical loss.
Enzymatische Umsetzung von Flavonoiden mit einer bakteriellen Chalconisomerase und einer Enoatreduktase
Authors: Gall Mechthild , Thomsen Maren , Peters Christin , Pavlidis Ioannis V. , Jonczyk Patrick , Grünert Philipp P. , Beutel Sascha , Scheper Thomas , Gross Egon , Backes Michael , Geißler Torsten , Ley Jakob P. , Hilmer Jens‐Michael , Krammer Gerhard , Palm Gottfried J. , Hinrichs Winfried , Bornscheuer Uwe T. 
Published: December 2013

AbstractFlavonoide stellen eine große Gruppe pflanzlicher Sekundärmetabolite dar und haben eine Vielzahl unterschiedlicher biologischer Eigenschaften. Aufgrund dessen stehen sie im Interesse vieler Wissenschaftler, da sie zu vielen industriell interessanten Verbindungen führen können. Das anaerobe Darmbakterium Eubacterium ramulus kann über einen bislang unbekannten Abbauweg diese Flavonoide verstoffwechseln. Über eine Vollgenom‐Sequenzierung wurden in dieser Arbeit die entscheidenden Enzyme, eine Chalconisomerase (CHI) und eine Enoatreduktase (ERED), identifiziert, kloniert und funktionell sogar unter aeroben Bedingungen exprimiert. Mittels Biotransformation des Flavanons zum Dihydrochalcon konnte der Flavonoid‐Abbauweg bewiesen werden. Der beide Enzyme exprimierende E.‐coli‐Stamm kann für die Umsetzung verschiedener Flavanone eingesetzt werden. Dies unterstreicht die Anwendbarkeit des in dieser Arbeit entwickelten biokatalytischen Systems.
Catalytic Enantioselective Amination of Alcohols by the Use of Borrowing Hydrogen Methodology: Cooperative Catalysis by Iridium and a Chiral Phosphoric Acid
Authors: Zhang Yao , Lim Ching‐Si , Sim Derek Sui Boon , Pan Hui‐Jie , Zhao Yu 
Published: December 2013

AbstractThe catalytic asymmetric reduction of ketimines has been explored extensively for the synthesis of chiral amines, with reductants ranging from Hantzsch esters, silanes, and formic acid to H2 gas. Alternatively, the amination of alcohols by the use of borrowing hydrogen methodology has proven a highly atom economical and green method for the production of amines without an external reductant, as the alcohol substrate serves as the H2 donor. A catalytic enantioselective variant of this process for the synthesis of chiral amines, however, was not known. We have examined various transition‐metal complexes supported by chiral ligands known for asymmetric hydrogenation reactions, in combination with chiral Brønsted acids, which proved essential for the formation of the imine intermediate and the transfer‐hydrogenation step. Our studies led to an asymmetric amination of alcohols to provide access to a wide range of chiral amines with good to excellent enantioselectivity.
Metal Oxide‐Coated Three‐Dimensional Graphene Prepared by the Use of Metal–Organic Frameworks as Precursors
Authors: Cao Xiehong , Zheng Bing , Rui Xianhong , Shi Wenhui , Yan Qingyu , Zhang Hua 
Published: December 2013

AbstractA simple method for the preparation of metal‐oxide‐coated three‐dimensional (3D) graphene composites was developed. The metal–organic frameworks (MOFs) that served as the precursors of the metal oxides were first synthesized on the 3D graphene networks (3DGNs). The desired metal oxide/3DGN composites were then obtained by a two‐step annealing process. As a proof‐of‐concept application, the obtained ZnO/3DGN and Fe2O3/3DGN materials were used in a photocatalytic reaction and a lithium‐ion battery, respectively. We believe this method could be extended to the synthesis of other metal oxide/3DGN composites with 3D structures simply through the appropriate choice of specific MOFs as precursors.
Hybrid‐Protein‐Zymogene durch Selbstorganisation dendritischer Schutzgruppen
Authors: Ng David Y. W. , Arzt Matthias , Wu Yuzhou , Kuan Seah Ling , Lamla Markus , Weil Tanja 
Published: December 2013

AbstractDie Steuerung der Aktivität und Zellaufnahme in Abhängigkeit von physiologischen Veränderungen stellt eine wesentliche Eigenschaft von intelligenten Proteintherapeutika dar. Wir beschreiben die Selbstorganisation einer pH‐schaltbaren PAMAM‐Dendrimerhülle auf der Oberfläche von katalytisch aktiven Enzymen (Trypsin, Papain, DNase I), die unter Bildung eines Dendrimer‐Enzym‐Komplexes als supramolekulare Schutzgruppe wirkt. Die Selbstorganisation basiert auf einer pH‐abhängigen Wechselwirkung, die es dem Komplex ermöglicht, reversibel auf pH‐Änderungen im Bereich von pH 5.0 bis 7.4 zu reagieren. In Gegenwart der Dendrimerhülle ist das Enzym inaktiv, während unter sauren Bedingungen durch Abspaltung der Dendrimerhülle die katalytische Aktivität vollständig wiederhergestellt wird. Im Unterschied zu den nativen Proteasen werden die Hybrid‐Protein‐Zymogene effizient in A549‐Zellen aufgenommen. In den sauren Zellkompartimenten erfolgt die programmierte Freisetzung der Proteasen, welche zelltoxisch wirken.
A Chaperonin as Protein Nanoreactor for Atom‐Transfer Radical Polymerization
Authors: Renggli Kasper , Nussbaumer Martin G. , Urbani Raphael , Pfohl Thomas , Bruns Nico 
Published: December 2013

AbstractThe group II chaperonin thermosome (THS) from the archaea Thermoplasma acidophilum is reported as nanoreactor for atom‐transfer radical polymerization (ATRP). A copper catalyst was entrapped into the THS to confine the polymerization into this protein cage. THS possesses pores that are wide enough to release polymers into solution. The nanoreactor favorably influenced the polymerization of N‐isopropyl acrylamide and poly(ethylene glycol)methylether acrylate. Narrowly dispersed polymers with polydispersity indices (PDIs) down to 1.06 were obtained in the protein nanoreactor, while control reactions with a globular protein–catalyst conjugate only yielded polymers with PDIs above 1.84.
Enzymatic Conversion of Flavonoids using Bacterial Chalcone Isomerase and Enoate Reductase
Authors: Gall Mechthild , Thomsen Maren , Peters Christin , Pavlidis Ioannis V. , Jonczyk Patrick , Grünert Philipp P. , Beutel Sascha , Scheper Thomas , Gross Egon , Backes Michael , Geißler Torsten , Ley Jakob P. , Hilmer Jens‐Michael , Krammer Gerhard , Palm Gottfried J. , Hinrichs Winfried , Bornscheuer Uwe T. 
Published: December 2013

AbstractFlavonoids are a large group of plant secondary metabolites with a variety of biological properties and are therefore of interest to many scientists, as they can lead to industrially interesting intermediates. The anaerobic gut bacterium Eubacterium ramulus can catabolize flavonoids, but until now, the pathway has not been experimentally confirmed. In the present work, a chalcone isomerase (CHI) and an enoate reductase (ERED) could be identified through whole genome sequencing and gene motif search. These two enzymes were successfully cloned and expressed in Escherichia coli in their active form, even under aerobic conditions. The catabolic pathway of E. ramulus was confirmed by biotransformations of flavanones into dihydrochalcones. The engineered E. coli strain that expresses both enzymes was used for the conversion of several flavanones, underlining the applicability of this biocatalytic cascade reaction.
Core‐Modified Analogues of Expanded Porphyrins Containing Rigid β,β′‐Linked o‐Phenylene Bridges
Authors: Shetti Vijayendra S. , Kee Se‐Young , Lee Chang‐Hee 
Published: December 2013

AbstractStructural modifications that lead to the creation of π‐extended aromatic macrocyles involving a heterocyclic ring other than pyrrole and rigid β‐β′ linkages have not been well studied up to date. The rigidity caused by the conformational restriction would change the spectroscopic properties of the system as compared with those of the normal congeners. With these considerations, we have synthesized and fully characterized π‐extended, core modified expanded porphyrins bearing rigid bipyrrole units. Core‐modified naphthorubyrins were synthesized by the Lewis acid‐catalyzed condensation of naphthobipyrrole with thiophene/furan diols, whereas naphthosapphyrins were obtained by reacting 2,9‐diformyl‐naphthobipyrrole with 16‐thia/oxatripyrranes under mild reaction conditions. The core‐modified analogues of both naphthorubyrin and naphthosapphyrin displayed the aromatic character. The dithiarubyrin analogues showed a lack of conformational change as expected and displayed well‐resolved 1H NMR resonances at room temperature. On the other hand, the oxasapphyrin analogue adopts a furan‐inverted geometry, and the ring inversion is independent of the protonation state. The oxanaphthosapphyrin also exhibited a weak fluorescence emission at 613 nm.
Robust Practical Stabilization of Nonholonomic Mobile Robots Based on Visual Servoing Feedback with Inputs Saturation
Authors: Chen Hua , Wang Chaoli , Liang Zhenying , Zhang Dongkai , Zhang Hengjun 
Published: December 2013

AbstractIn this paper, the saturated practical stabilization problem is addressed for a class of nonholonomic mobile robots based on visual servoing feedback with uncertain camera parameters. The new switching control design method to be proposed is directly based on the original system, which can avoid the problem of singularity arising from state or input transformation. A saturated discontinuous controller is presented by applying the multi‐step switching control strategy and the theory of finite‐time stability. The closed‐loop system can be stabilized to a prescribed arbitrarily small neighborhood of the zero equilibrium point in a finite time. Finally, the simulation results show the effectiveness of the proposed controller design approach.
Rhamsan gum production by Sphingomonas sp. CGMCC 6833 using a two‐stage agitation speed control strategy
Authors: Xu Xiao Ying , Zhu Ping , Li Sha , Chen Xiao Ye , Jiang Xing Huan , Xu Hong 
Published: December 2013

AbstractVarying the agitation speed could greatly affect rhamsan gum production by Sphingomonas sp. CGMCC 6833. Batch fermentations at agitation speeds of 400, 600, 800, and 1,000 rpm were therefore carried out. The time course of specific cell growth rate, specific glucose consumption rate, and specific rhamsan gum formation rate was subsequently determined. Based on the results, a novel two‐stage agitation speed control strategy was developed. From 0 to 13 H, the high specific cell growth and glucose consumption rates were achieved by setting the agitation speed of the fermenter at 800 rpm. From 13 H onward to the end of fermentation, the glucose consumption rate and specific cell growth rate were high at the agitation speed of 600 rpm. Using this method, the maximum concentration and productivity of rhamsan gum reached 21.63 ± 1.76 g L−1 and 0.338 ± 0.028 g L−1 H−1, respectively, which were both higher than the optimum results obtained at constant agitation speeds.
Simultaneous determination of imperatorin and its metabolites in vitro and in vivo by a GC‐MS method: application to a bioavailability and protein binding ability study in rat plasma
Authors: Zhao Gang , Peng Cheng , Du Wei , Wang Sicen 
Published: December 2013

ABSTRACTIn this study, a simple and sensitive gas chromatography–mass spectrometry method was developed for the study of bioavailability and protein binding and the metabolism of imperatorin in rat. The results showed that the pharmacokinetics of imperatorin after intravenous and oral administration in rats exhibited linear characteristics. The absolute bioavailability of imperatorin was calculated as ~3.85, ~33.51 and ~34.76% for 6.25, 12.5 and 25 mg/kg, respectively. The low bioavailability of imperatorin may be attributed to the poor absorption or extensive metabolism. The phase I metabolites of imperatorin formed in vitro by rat liver microsomes were studied, and two metabolites were isolated and identified as xanthotoxol and heraclenin. Following oral administration of imperatorin, one metabolite (heraclenin) was detected in rat plasma, and two potential metabolites (xanthotoxol and heraclenin) were detected in rat urine. However, none of potential metabolites was detected in rat feces and bile. The results showed that the metabolites of imperatorin were excreted by kidney, and heraclenin was associated with an active component. Demethylation and oxygenization were the main metabolic pathways. In vitro plasma protein binding of imperatorin was 90.1 and 92.6% for the spiked rat plasma concentrations of 1.0 and 50.0 µg/mL, respectively, indicating that imperatorin showed slow distribution into the intra‐ and extracellular space. Copyright © 2013 John Wiley & Sons, Ltd.
A Systematic Investigation of Iminosugar Click Clusters as Pharmacological Chaperones for the Treatment of Gaucher Disease
Authors: Joosten Antoine , Decroocq Camille , de Sousa Julien , Schneider Jérémy P. , Etamé Emile , Bodlenner Anne , Butters Terry D. , Compain Philippe 
Published: December 2013

AbstractA series of 18 mono‐ to 14‐valent iminosugars with different ligands, scaffolds, and alkyl spacer lengths have been synthesized and evaluated as inhibitors and pharmacological chaperones of β‐glucocerebrosidase (GCase). Small but significant multivalent effects in GCase inhibition have been observed for two iminosugar clusters. Our study provides strong confirmation that compounds that display the best affinity for GCase are not necessarily the best chaperones. The best chaperoning effect observed for a deprotected iminosugar cluster has been obtained with a tetravalent 1‐deoxynojirimycin (DNJ) analogue (3.3‐fold increase at 10 μM). In addition, our study provides the first evidence of the high potential of prodrugs for the development of potent pharmacological chaperones. Acetylation of a trivalent DNJ derivative, to give the corresponding acetate prodrug, leads to a pharmacological chaperone that produces higher enzyme activity increases (3.0‐fold instead of 2.4‐fold) at a cellular concentration (1 μM) reduced by one order of magnitude.
First‐in‐Man Study of the Low‐Dose Paclitaxel Using the COBRA‐P Drug‐Eluting Coronary Stent System With a Novel Biodegradable Coating in De Novo Coronary Lesions
Authors: Nakatani Daisaku , Waseda Katsuhisa , Ako Junya , Calderas Carlos , Condado Jose A. , Condado Jose F. , Honda Yasuhiro , Fitzgerald Peter J. 
Published: December 2013

ObjectiveThe aim of this first‐in‐man trial was to evaluate vessel response of two doses of the balloon expandable Cobra‐P drug‐eluting coronary stent (DES).BackgroundThe Cobra‐P DES system consists of a cobalt chromium alloy with bioabsorbable siloxane sol–gel matrix coating that elutes low dose paclitaxel.MethodsA total of 60 lesions (54 patients) were sequentially assigned to extremely low‐dose (group A: 3.7 µg/18 mm; n = 30, 1/33 dose of the TAXUS Liberte) or low‐dose (group B: 8 µg/18 mm; n = 30) arm. Intravascular ultrasound images were obtained at post‐procedure and at 4 months.ResultsPatient and lesion characteristics were matched between the two groups except for the higher prevalence of men in group B. At 4 months, there were no significant differences in neointimal obstruction (13.5 ± 9.5% vs. 10.9 ± 7.8%, P = 0.276), and maximum cross‐sectional narrowing (31.2 ± 14.3% vs. 28.6 ± 16.1%, P = 0.523) between the two groups. Late‐acquired incomplete stent apposition occurred in four cases in each arm (P = 1.000). Although the volume of late‐acquired incomplete stent apposition did not differ between the two groups (1.0 ± 0.6 mm3 vs. 8.6 ± 10.9 mm3, P = 0.200), maximum late‐acquired incomplete stent apposition area was significantly smaller in group A than in group B (1.1 ± 0.3 mm2 vs. 2.5 ± 1.4 mm2, P = 0.029).ConclusionsIn the first‐in‐man study of the Cobra‐P DES, neointimal hyperplasia at 4 months appears to be similar between extremely low‐dose and low‐dose groups. Although the incidence of late‐acquired incomplete stent apposition was similar, the magnitude of the late‐acquired gap between the stent and vessel was greater in the low‐dose group compared with the extremely low‐dose group. © 2013 Wiley Periodicals, Inc.