bluuebunny/crossref_metadata_2025_split huggingface dataset:
Antidepressants and alcohol use disorder: A multicenter study on the mediating role of depression symptom changes
Authors: Jaeger Joshua , Osterburg Lara , Stein Maria , Germann Miranda , Lustenberger Sara A. , Wopfner Alexander , Denier Niklaus , Bracht Tobias , Moggi Franz , Soravia Leila M. 
Published: July 2024

AbstractBackgroundAlcohol use disorder (AUD) and depression are highly prevalent and tied to significant psychological, physiological, social and economic consequences. Their co‐occurrence presents a complex clinical challenge, as the impact of antidepressant medication on AUD outcomes remains equivocal. In this multicenter, longitudinal study we investigated the relationship between antidepressant medication and changes in depression symptoms and alcohol use in AUD patients.MethodsWe analyzed data from 153 detoxified AUD patients who attended a 12‐week residential treatment program between 2015 and 2019. Within a mediation analysis, adopting a bootstrapping approach and a quasi‐Bayesian framework, we estimated the total, direct, and mediated effects of antidepressants on the percentage of days abstinent to assess the role of changes in depression symptoms as a mediating factor.ResultsThe mediation analysis revealed a dual impact pathway model with a negative direct effect of antidepressants on abstinence (p = 0.004) and a positive indirect effect, mediated through the reduction of depression symptoms (p = 0.002).ConclusionsThe findings of the mediation analysis show that patients treated with antidepressants and whose depression symptoms do not improve over time show more relapses, while patients treated with antidepressants who achieve a reduction in depression symptoms show fewer relapses over time. Thus, to optimize treatment outcome, depression symptoms should be vigilantly monitored when antidepressants are prescribed during AUD treatment.
The effectiveness of development‐oriented nonreciprocal trade preferences in promoting agricultural trade
Authors: Ridley William , Shirin Farzana 
Published: July 2024

AbstractNonreciprocal trade preference (NRTP) programs have proliferated in recent decades as a means to facilitate export‐led growth for beneficiary countries. However, evidence on the efficacy of NRTPs in promoting agricultural exports from preference beneficiaries to preference donors has been mixed. We investigate the impacts of NRTPs on such trade in a structural gravity setting for 23 major agricultural commodities prominent in the export baskets of developing countries. Based on estimates from a commodity‐level gravity model and the structural foundation of the gravity framework, we quantify the trade impacts of NRTP programs in a counterfactual simulation analysis. Our results show that NRTPs were responsible for around $833 million in elevated annual exports (a 1.7% increase) from NRTP beneficiary countries to donor countries as of 2018, and we document considerable heterogeneity in the countries and commodities that undergo the largest impacts. Our findings thus highlight the evolving role of trade policy as a facilitator of export‐driven growth and suggest that NRTP programs are often limited in their capacity to promote agricultural trade.
Neutrophil‐to‐lymphocyte ratio may predict complications and patency in bile duct injury repair
Authors: Martinez‐Mier Gustavo , Carbajal‐Hernández Regina , López‐García Mario , Vázquez‐Ramirez Jorge A. , Reyes‐Ruiz José M. , Solórzano‐Rubio Jose R. , González‐Grajeda José L. , Moreno‐Ley Pedro I. 
Published: July 2024

AbstractBackgroundBile duct injury (BDI) repair surgery is usually associated with morbidity/mortality. The neutrophil‐to‐lymphocyte ratio (NLR) easily assesses a patient's inflammatory status. The study aims to determine the possible relationship between preoperative NLR (pNLR) with postoperative outcomes in BDI repair surgery.MethodsApproved Ethics/Research Committee retrospective study, in patients who had a Bismuth‐Strasberg type E BDI repair (2008–2023). Data registered was: morbidity, mortality, and long‐term outcomes (primary patency and loss of primary patency) (Kaplan–Meier). Group comparison (U Mann–Whitney), receiver operator characteristic (ROC): area under curve [AUC]; cut‐off value, and Youden index [J], and logistic regression analysis were used for pNLR evaluation.ResultsSeventy‐three patients were studied. Mean age was 44.4 years. E2 was the commonest BDI (38.4%). Perioperative morbidity/mortality was 31.5% and 1.4%. Primary patency was 95.9%. 8.2% have lost primary patency (3‐year actuarial patency: 85.3%). Median pNLR was higher in patients who had any complication (4.84 vs. 2.89 p = 0.015), biliary complications (5.29 vs. 2.86 p = 0.01), and patients with loss of primary patency (5.22 vs. 3.1 p = 0.08). AUC's, cut‐off values and (J) were: any complication (0.678, pNLR = 4.3, J = 0.38, p = 0.007), serious complication (0.667, pNLR = 4.3, J = 0.34, p = 0.04), biliary complications (0.712, pNLR = 3.64, J = 0.46, p = 0.001), and loss of primary patency (0.716, pNLR = 3.24, J = 0.52, p = 0.008). Logistic regression was significant in any complication (Exp [B]: 0.1, p = 0.002), serious complications (Exp [B]: 0.2, p = 0.03), and biliary complications (Exp [B]: 8.1, p = 0.003).ConclusionspNLR is associated with complications in BDI repair with moderate to acceptable predictive capacity. pNLR could potentially predict patency of a BDI repair.
Predictors of surgical intervention in first episode primary spontaneous pneumothorax requiring chest drain insertion
Authors: McNamara Nicholas , Cistulli David , Bannon Paul , Cao Christopher 
Published: July 2024

AbstractBackgroundPrimary spontaneous pneumothorax occurs in patients with no underlying lung disease and guidelines recommend chest tube drainage for the first episode, with surgical intervention reserved for recurrent episodes, persistent air leak or failure of lung re‐expansion. Modern surgical management is associated with reduced length of hospital stay and superior freedom from recurrence compared with chest tube drainage alone. The objective of this study was to identify risk factors for failed chest tube drainage in patients who present with first episode primary spontaneous pneumothorax.MethodsA retrospective analysis of patients who presented to Royal Prince Alfred Hospital, Australia with first episode PSP and underwent chest tube insertion was performed. Patient demographics and size of pneumothorax were examined in relation to the primary outcome, a composite of failed chest tube drainage and recurrent ipsilateral pneumothorax.ResultsFifty‐five patients underwent chest tube drainage for first episode primary spontaneous pneumothorax between 1st January 2017 and 31st December 2020. Complete lung collapse on admission chest x‐ray was associated with an increased risk of the primary outcome (63% versus 19%, OR 7.3 [96% CI 2.0–27.4), P = 0.004).ConclusionThis small retrospective study found that patients that undergo chest drain insertion for first episode primary spontaneous pneumothorax who present with complete lung collapse on admission are at high risk of requiring pleurodesis and therefore may benefit from early surgical referral.
The effect of twin pregnancy in intrahepatic cholestasis of pregnancy: A case control study
Authors: Axelsen Silja Maigaard , Schmidt Maria Cathrine , Kampmann Ulla , Grønbæk Henning , Fuglsang Jens 
Published: July 2024

AbstractIntroductionIntrahepatic cholestasis of pregnancy (ICP) is one of the most common hepatic disorders during pregnancy, and the etiology is thought to be multifactorial including both environmental and hormonal contributions. In twin pregnancies, the fetal and placental mass is generally greater than in singleton pregnancies, and is, theoretically, likely to have a greater influence upon the maternal hepatic metabolism compared to singleton pregnancy. The aim of this study was to compare ICP in twin and singleton pregnancies according to ICP characteristics, time of diagnosis, serum bile acid levels, pharmacological treatment, and pregnancy outcomes.Material and MethodsThis case control study was undertaken at Aarhus University Hospital, Denmark, from 2012 to 2019. The study comprised 51 women with twin pregnancies and ICP. These women were matched with 153 women with twin pregnancies without ICP and 153 women with singleton pregnancies with ICP, respectively. Three controls were matched per case, and data obtained from medical records and Danish obstetrical databases were compared.ResultsWe found a significantly lower gestational age at ICP diagnosis in twin pregnancies (227 vs. 242 days for singleton pregnancies; p = 0.002). Bile acids reached significantly higher maximum blood levels in twin pregnancies (32.9 vs. 22.2 μmol/L; p = 0.012), and at a lower gestational age (gestational age maximum bile acids: 235 vs. 250 days; p < 0.001). No difference in pharmacological treatment was observed between the groups. Twin pregnancies with and without ICP had comparable pregnancy outcomes; however, ICP pregnancies had a higher incidence of gestational diabetes mellitus (15.7% vs. 5.2%; p = 0.03). In repeat pregnancies, ICP was diagnosed earlier in the twin pregnancy (p = 0.006).ConclusionsCompared to singleton pregnancies, twin pregnant women with ICP have an earlier diagnosis of ICP, and levels of bile acids are higher. Compared to twin pregnancies without ICP, the pregnancy outcomes are comparable.
The historical background of hereditary cystatin C amyloid angiopathy: Genealogical, pathological, and clinical manifestations
Authors: Snorradottir Asbjorg Osk , Hakonarson Hakon , Palsdottir Astridur 
Published: July 2024

AbstractHereditary cystatin C amyloid angiopathy (HCCAA) is an Icelandic disease that belongs to a disease class called cerebral amyloid angiopathy, a group of heterogenous diseases presenting with aggregation of amyloid complexes and deposition predominantly in the central nervous system. HCCAA is dominantly inherited, caused by L68Q mutation in the cystatin C gene, leading to aggregation of the cystatin C protein. HCCAA is a very progressive and severe disease, with widespread cerebral and parenchymal cystatin C and collagen IV deposition within the central nervous system (CNS) but also in other organs in the body, for example, in the skin. Most L68Q carriers have clinical symptoms characterized by recurrent hemorrhages and dementia, between the age of 20–30 years. If the carriers survive the first hemorrhage, the frequency and severity of the hemorrhages tend to increase, resulting in death at average of 30 years with mean number of major hemorrhages ranging from 3.2 to 3.9 over a 5‐year average life span. The pathogenesis of the disease in carriers is very similar in the CNS and in the skin based on autopsy studies, thus skin biopsies can be used to monitor the progression of the disease by quantifying the cystatin C immunoreactivity. The cystatin C deposition always colocalizes with collagen IV and fibroblasts in the skin are found to be the main cell type responsible for the deposition of both proteins. No therapy is available for this devastating disease.
Endophthalmitis following intravitreal injections administered by junior medical officers in rural Western Australia
Authors: Lee Jackson Chee Chea , Razavi Hessom , Nejatian Marcel Maziyar , Drinkwater Jocelyn , Turner Angus Warwick 
Published: July 2024

AbstractBackgroundPatients in rural Australia have limited access to intravitreal treatments due to a maldistribution of the ophthalmology workforce. To improve access, a novel outreach service model was implemented whereby junior medical staff administered intravitreal injections under a supervising ophthalmology consultant. This model involves outreach visits in hospitals, mobile clinics and a remote hub with intravitreal injections administered by junior doctors overseen by an ophthalmologist. The article explores the safety of this approach with respect to the rate of post‐injection endophthalmitis.MethodsA retrospective audit was conducted by the Lions Outback Vision outreach ophthalmology service from 2017 to mid‐2023. The number of injections, locations, diagnoses, intravitreal agents used, designation of administering doctor and cases of endophthalmitis were reviewed.ResultsA 12 632 intravitreal injections were administered across 32 locations throughout rural Western Australia in the 6.5‐year period. Three cases of endophthalmitis occurred representing a rate of 0.0237%.ConclusionThe rate of endophthalmitis in the outreach service is comparable to other centres. The outreach model with supervising ophthalmology consultant support in person or via telehealth and administration of injections by junior medical staff has improved access for underserved or marginalised populations.
Toward 3D facial analysis for recognizing Mendelian causes of autism spectrum disorder
Authors: Sleyp Yoeri , Matthews Harold S. , Vanneste Michiel , Vandenhove Laura , Delanote Valentine , Hoskens Hanne , Indencleef Karlijne , Teule Hanne , Larmuseau Maarten H. D. , Steyaert Jean , Devriendt Koenraad , Claes Peter , Peeters Hilde 
Published: July 2024

AbstractRecognizing Mendelian causes is crucial in molecular diagnostics and counseling for patients with autism spectrum disorder (ASD). We explored facial dysmorphism and facial asymmetry in relation to genetic causes in ASD patients and studied the potential of objective facial phenotyping in discriminating between Mendelian and multifactorial ASD. In a cohort of 152 ASD patients, 3D facial images were used to calculate three metrics: a computational dysmorphism score, a computational asymmetry score, and an expert dysmorphism score. High scores for each of the three metrics were associated with Mendelian causes of ASD. The computational dysmorphism score showed a significant correlation with the average expert dysmorphism score. However, in some patients, different dysmorphism aspects were captured making the metrics potentially complementary. The computational dysmorphism and asymmetry scores both enhanced the individual expert dysmorphism scores in differentiating Mendelian from non‐Mendelian cases. Furthermore, the computational asymmetry score enhanced the average expert opinion in predicting a Mendelian cause. By design, our study does not allow to draw conclusions on the actual point‐of‐care use of 3D facial analysis. Nevertheless, 3D morphometric analysis is promising for developing clinical dysmorphology applications in diagnostics and training.
Shared genetics and causal association between plasma levels of SARS‐CoV‐2 entry receptor ACE2 and Alzheimer's disease
Authors: Zhang Yan , Xu Fang , Wang Tao , Han Zhifa , Shang Hong , Han Kevin , Zhu Ping , Gao Shan , Wang Xiaojie , Xue Yanli , Huang Chen , Chen Yan , Liu Guiyou 
Published: July 2024

AbstractBackgroundAlzheimer's disease (AD) is the highest risk of COVID‐19 infection, hospitalization, and mortality. However, it remains largely unclear about the link between AD and COVID‐19 outcomes. ACE2 is an entry receptor for SARS‐CoV‐2. Circulating ACE2 is a novel biomarker of death and associated with COVID‐19 outcomes.MethodsHere, we explored the shared genetics and causal association between AD and plasma ACE2 levels using large‐scale genome‐wide association study, gene expression, expression quantitative trait loci, and high‐throughput plasma proteomic profiling datasets.ResultsWe found a significant causal effect of genetically increased circulating ACE2 on increased risk of AD. Cross‐trait association analysis identified 19 shared genetic variants, and three variants rs3104412, rs2395166, and rs3135344 at chromosome 6p21.32 were associated with COVID‐19 infection, hospitalization, and severity. We mapped 19 variants to 117 genes, which were significantly upregulated in lung, spleen, and small intestine, downregulated in brain tissues, and involved in immune system, immune disease, and infectious disease pathways. The plasma proteins corresponding to LST1, AGER, TNXB, and APOC1 were predominantly associated with COVID‐19 infection, ventilation, and death.ConclusionTogether, our findings suggest the shared genetics and causal association between AD and plasma ACE2 levels, which may partially explain the link between AD and COVID‐19.
A SALT on real estate? Housing market and migration responses to the limit on the state and local tax deduction
Authors: Kessler Lawrence M. , Bruce Donald 
Published: July 2024

AbstractThe 2017 Tax Cuts and Jobs Act placed a $10,000 limit on the deductibility of state and local taxes (SALT) for federal tax purposes. This policy change likely increased the cost of home ownership for some households in high‐tax areas. We examine whether these costs were capitalized into the local housing market through slower growth in housing prices. Motivated by the argument that the SALT cap caused some taxpayers to relocate, we also examine whether the cap influenced interstate migration patterns. The cap led to a sizable reduction in home price growth but had no discernable impact on state‐to‐state migration.
Treatment Adherence and Health Status of Patients With COPD Under Treatment With Salmeterol/Fluticasone via the Elpenhaler® Device: The AHEAD Study
Authors: Exarchos Konstantinos P. , Hillas Georgios , Steiropoulos Paschalis , Papanastasiou Polyanthi , Gogali Athena , Kostikas Konstantinos 
Published: July 2024

ABSTRACTBackgroundChronic obstructive pulmonary disease (COPD) is a heterogeneous progressive lung condition characterized by long‐term respiratory symptoms and airflow limitation. Appropriate bronchodilation is the cornerstone of COPD treatment, leading to better health status as well as benefits in prognosis and mortality.MethodsIn the current open, noninterventional, observational study, 716 patients diagnosed with COPD of variable severity were administered a fixed‐dose combination (FDC) of fluticasone propionate and salmeterol (500 + 50 mcg) through the Elpenhaler® device. The patients' adherence to treatment (based on the MMAS‐8 [8‐item Morisky Medication Adherence Scale]) and health status (based on the CCQ [Clinical COPD Questionnaire]) were assessed at the beginning of the study and at the end of the 3‐month follow‐up period.ResultsThe mean ± SD MMAS‐8 score at 1 and 3 months was 6.12 ± 1.89 and 6.45 ± 1.80, respectively, indicating medium adherence overall; however, there was a statistically significant increase of 0.33 units in the MMAS‐8 score at the end of the follow‐up (paired t‐test p < 0.0001), suggestive of an improvement in adherence throughout the study. Higher adherence was associated with better health status at baseline, which further improved by the end of the follow‐up. Moreover, we observed a statistically significant decrease of 1.07 points (p < 0.0001) in the mean CCQ total score from the baseline (CCQ score = 2.2 ± 1.00) until the end of the study follow‐up (CCQ score = 1.13 ± 0.67). Similar conclusions were also drawn in the mean domain scores regarding symptoms (score equal to 1.36 ± 0.72, decrease by 1.18) as well as functional and mental state (scores equal to 0.86 ± 0.73 and 1.20 ± 0.88, decrease by 1.04 and 1.00, respectively, p < 0.0001). Similarly, when patients were stratified into subgroups with and without comorbidities, the former group showed an increase of 7% in the patients with medium to high adherence during the course of the study. In the same patient subgroup, there was a notable decrease in CCQ score by 1.18 points (p < 0.0001) during the study.ConclusionsThe administration of FDC of fluticasone propionate and salmeterol, (500 + 50 mcg) via the Elpenhaler® device for COPD, resulted in a well‐maintained or slight increase in treatment adherence and a subsequent benefit in health status, which further persisted after 3 months of treatment.
From media campaign to local governance transition: Lessons for community‐based conservation from an Amur falcon hunting ban in Nagaland, India
Authors: Kudalkar Sahila , Veríssimo Diogo 
Published: July 2024

AbstractMedia campaigns can spur conservation action but may alienate local communities. Transforming such action into self‐sustaining community‐based conservation involves effective governance that rapidly integrates knowledge of resource dynamics, establishes flexible institutions, and fosters multilevel networks. This study examines the emergence of community‐based conservation in response to a media campaign to protect migratory Amur falcons, illustrating shifts in governance and power dynamics that enabled local community ownership. Although conservation developed in the absence of an adequate preparation phase, external engagement, incentives, and recognition of local institutions' legitimacy were instrumental in fostering collective action. This research showcases how community‐based conservation initiatives can be triggered by external social pressure but also how the long‐term sustainability relies on effective governance that respects local institutions and employs cooperative strategies to build trust and foster ownership among local communities.
Are we ready to bridge classification systems? A comprehensive review of different reporting systems in thyroid cytology
Authors: Rossi Esther Diana , Pantanowitz Liron 
Published: July 2024

AbstractThe evaluation of thyroid lesions is common in the daily practice of cytology. While the majority of thyroid nodules are benign, in recent decades, there has been increased detection of small and well‐differentiated thyroid cancers. Combining ultrasound evaluation with fine‐needle aspiration cytology (FNAC) is extremely useful in the management of thyroid nodules. Furthermore, the adoption of specific terminology, introduced by different thyroid reporting systems, has helped effectively communicate thyroid FNAC diagnoses in a clear and understandable way. In 1996, the Papanicolaou Society thyroid cytological classification was introduced. This was followed in 2005 by the first Japanese and then in 2007 by the Bethesda System for Reporting Thyroid Cytopathology, which subsequently underwent two revisions. Other international thyroid terminology classifications include the British, Italian, Australasian and other Japanese cytology systems. This review covers similarities and differences among these cytology classification systems and highlights key points that unify these varied approaches to reporting thyroid FNAC diagnoses.
Does botulinum neurotoxin A make walking easier in children with cerebral palsy? A randomized clinical trial
Authors: Brændvik Siri Merete , Ross Raftemo Anne Elisabeth , Roeleveld Karin , Andersen Guro Lillemoen , Ramstad Kjersti , Follestad Turid , Aarli Ånen , Bonikowski Marcin , Vik Torstein ,   Walking Easier
Published: July 2024

AbstractAimTo assess the effect of single botulinum neurotoxin A (BoNT‐A) injections into the calf muscles on the gross energy cost of walking in children with cerebral palsy (CP) and to evaluate the effect of BoNT‐A on walking capacity, physical activity, perceived changes in mobility, and pain.MethodThis was an industry‐independent, randomized, quadruple‐blind, placebo‐controlled, multicentre trial (ClinicalTrials.gov registration: NCT02546999). Sixty‐one children (33 male, median age [range] = 8 years [4–16 years]) with spastic CP and classified in Gross Motor Function Classification System (GMFCS) levels I and II allocated to single injections of either BoNT‐A or 0.9% saline into the calf muscles. The main outcome was gross energy cost (J/kg/m); secondary outcomes were walking capacity, habitual physical activity, perceived change in mobility tasks, and calf pain at baseline, 4 weeks (P1), 12 weeks (P2), and 24 weeks (P3) after the injection.ResultsThe mean change in energy cost did not differ significantly between groups at the primary time point P2 (−0.27 J/kg/m, 95% confidence interval − 0.91 to 0.36, p = 0.404), nor at P1 or P3. Regarding the secondary outcomes, there was some evidence of a larger reduction in pain intensity in the group given BoNT‐A (p = 0.043).InterpretationOne treatment with BoNT‐A was not superior to placebo in making walking easier in children with CP classified in GMFCS levels I and II, at least in the short term. BoNT‐A may have a pain‐reducing effect.