bluuebunny/crossref_metadata_2025_split huggingface dataset:
A long-term assessment of pesticide mixture effects on aquatic invertebrate communities
Authors: Hasenbein Simone , Lawler Sharon P. , Geist Juergen , Connon Richard E. 
Published: November 2015

Abstract

To understand the potential effects of pesticide mixtures on aquatic ecosystems, studies that incorporate increased ecological relevance are crucial. Using outdoor mesocosms, the authors examined long-term effects on aquatic invertebrate communities of tertiary mixtures of commonly used pesticides: 2 pyrethroids (permethrin, λ-cyhalothrin) and an organophosphate (chlorpyrifos). Application scenarios were based on environmentally relevant concentrations and stepwise increases of lethal concentrations from 10% (LC10) to 50% (LC50) based on laboratory tests on Hyalella azteca and Chironomus dilutus; repeated applications were meant to generally reflect runoff events in a multiple-grower or homeowner watershed. Pyrethroids rapidly dissipated from the water column, whereas chlorpyrifos was detectable even 6 wk after application. Twelve of 15 macroinvertebrate and 10 of 16 zooplankton taxa responded to contaminant exposures. The most sensitive taxa were the snail Radix sp., the amphipod H. azteca, the water flea Daphnia magna, and copepods. Environmentally relevant concentrations had acute effects on D. magna and H. azteca (occurring 24 h after application), whereas lag times were more pronounced in Radix sp. snails and copepods, indicating chronic sublethal responses. Greatest effects on zooplankton communities were observed in environmentally relevant concentration treatments. The results indicate that insecticide mixtures continue to impact natural systems over multiple weeks, even when no longer detectable in water and bound to particles. Combinations of indirect and direct effects caused consequences across multiple trophic levels. Environ Toxicol Chem 2016;35:218–232. © 2015 SETAC
Stability of methylation markers in head and neck squamous cell carcinoma
Authors: Virani Shama , Light Emily , Peterson Lisa A. , Sartor Maureen A. , Taylor Jeremy M. G. , McHugh Jonathan B. , Wolf Gregory T. , Rozek Laura S. ,   and Investigators of the University of Michigan Head and Neck Specialized Programs of Research Excellence (SPORE) Program
Published: November 2015

AbstractBackgroundAs cancer progresses, methylation patterns change to promote the tumorigenic phenotype. However, stability of methylation markers over time and the extent that biopsy samples are representative of larger tumor specimens are unknown. This information is critical for clinical use of such biomarkers.MethodsNinety‐eight patients with tumor specimens from 2 timepoints were measured for DNA methylation in the promoter regions across 4 genes.ResultsThere were no significant differences in overall methylation of CCNA1 (cyclin A1), NDN (necdin), deleted in colorectal carcinoma (DCC), and cluster of differentiation 1a (CD1A) within paired specimens (p values = .56, .17, .66, and .58, respectively). All genes showed strong correlations between paired specimens across time. Methylation was most consistent for CCNA1 and NDN over time.ConclusionThis report provides the first evidence that methylation markers measured in biopsy samples are representative of gene methylation in later specimens and suggests that biopsy markers could be representative biomarkers for use in defining personalized treatment utilizing epigenetic changes. © 2015 Wiley Periodicals, Head Neck 38: E1325–E1331, 2016
Novel treatment for early‐stage nasal natural killer/T‐cell lymphoma: intra‐maxillary arterial infusion chemotherapy with concomitant radiotherapy
Authors: Takahara Miki , Nagato Toshihiro , Kishibe Kan , Ueda Seigo , Komabayashi Yuki , Yamashina Masaaki , Takahashi Kouji , Harabuchi Yasuaki 
Published: November 2015

AbstractNasal natural killer (NK)/T‐cell lymphoma (NNKTL) displays unusual clinicopathological features, and the prognosis is very poor, even in the early stages of the disease. For early stage NNKTL, we have developed a novel chemoradiotherapy regimen incorporating arterial infusion chemotherapy, administered via the superficial temporal artery, in combination with radiotherapy. The novel arterial infusion regimen consists of ifosfamide, carboplatin, methotrexate, peplomycin, and etoposide (MPVIC‐P). From 2003 to 2011, 12 patients with early stage NNKTL were treated with the MPVIC‐P regimen via arterial infusion with concomitant radiotherapy (54 Gy). We have previously reported on the presence of Epstein‐Barr virus (EBV) genetic DNA in NNKTL. Therefore, the effect of the treatment was evaluated by using both clinical findings and serum EBV DNA copy number. The observation period ranged from 39 months to 111 months post‐treatment (median: 81 months). All 12 patients achieved and maintained complete remission and, to date, show no sign of relapse. Serum EBV DNA copy numbers decreased to below detectable levels in all 12 patients tested. Manageable mucositis was the most common grade 3–4 toxicity, and it was seen in 10 (83%) patients. However, grade 3–4 hematological toxicity was only seen in 4 (33%) patients. We conclude that our regimen of intra‐maxillary arterial chemotherapy with concomitant radiotherapy is an effective treatment with minimal toxicity for early stage NNKTL. Copyright © 2015 John Wiley & Sons, Ltd.
Impulsivity as a precedent factor for problematic Internet use: How can we be sure?
Authors: Chen Ssu‐Kuang , Lo Meng‐Ting , Lin Sunny S. J. 
Published: November 2015

AbstractPrevious research has suggested that problematic Internet use (PIU) is associated with impulse control disorder. Although researchers have suggested that impulsivity is a risk factor for PIU, the literature lacks longitudinal evidence on the relationship between impulsivity and PIU. We aimed to use a cross‐lagged analytic framework to identify temporal order effects and hypothesised that impulsivity was the precedent factor for PIU. In a panel sample of college students (N = 367), trait impulsivity and PIU were measured in the spring of freshman year and in their junior year. The measures included a self‐developed PIU Scale and the revised Impulsiveness Scale based on Barratt's concept. We found that “non‐planning impulsivity” was not associated with PIU. The “motor impulsivity” subfactor was thus adopted in the cross‐lagged model. The results suggest that motor impulsivity and PIU were stable across time. Motor impulsivity at Time 1 positively predicted PIU at Time 2, but PIU at Time 1 did not predict motor impulsivity at Time 2. A further investigation using gender as a moderator found a gender difference in the temporal relationship. Because motor impulsivity is a risk factor for PIU, potential prevention strategies based on this result are suggested.
Hybrid method of strain estimation in optical coherence elastography using combined sub‐wavelength phase measurements and supra‐pixel displacement tracking
Authors: Zaitsev Vladimir Y. , Matveyev Alexander L. , Matveev Lev A. , Gelikonov Grigory V. , Gubarkova Ekaterina V. , Gladkova Natalia D. , Vitkin Alex 
Published: November 2015

A novel hybrid method which combines sub‐wavelength‐scale phase measurements and pixel‐scale displacement tracking for robust strain mapping in compressional optical coherence elastography is proposed. Unlike majority of OCE methods it does not rely on initial reconstruction of displacements and does not suffer from the phase‐wrapping problem for super‐wavelength displacements. Its robustness is enabled by direct fitting of local phase gradients obviating the necessity of phase unwrapping and error‐prone numerical differentiation. Furthermore, axial displacements significantly exceeding not only the optical wavelength, but pixel scales (i.e., multiple wavelengths) can be efficiently tracked and compensated. This feature strongly reduces errors in phase‐gradient estimation and ensures high robustness with respect to both additive and decorrelation noises.
Illustration of exceptionally high tolerance of the proposed method to noises: contrast of only 25% in the stiffness of the layers is clearly seen in the strain map even for equal intensities of the OCT signal and additive noise (SNR = 0 dB).magnified imageIllustration of exceptionally high tolerance of the proposed method to noises: contrast of only 25% in the stiffness of the layers is clearly seen in the strain map even for equal intensities of the OCT signal and additive noise (SNR = 0 dB).
AKT as Locus of Cancer Unknown Primary Site
Authors: Radisavljevic Ziv 
Published: November 2015

ABSTRACTCancer of unknown primary site is a metastasis developed by the positive feedback loops of primary cancer forming extreme cancer robustness. Such robustness occurs only in metastatic cancer or in relapsed lymphoma, myeloma, plasmocytoma, or leukemia. However, when it develops in primary cancer, hypoxic microenvironment generates positive feedback loops which hyperactivate AKT locus, forming extreme robustness that forcing cancer cells to migrate to the distant site, but primary cancer loosing that property or remains silent. Positive loops are the force and principal mechanism of metastasis development. A cancer cell is converted normal cell. Conversion occurs at the AKT genomic locus. Thus, cancer is genomic disease rather than disease of the specific organs. Targeting such locus by the locus chemotherapy (redox balance change) rather than by organ specific therapy results in conversion of positive loops into negative and disappearance of extreme robustness and malignant phenotype of the cancer unknown primary origin. J. Cell. Biochem. 117: 1066–1068, 2016. © 2015 Wiley Periodicals, Inc.
Kallikrein Promotes Inflammation in Human Dental Pulp Cells Via Protease‐Activated Receptor‐1
Authors: Hayama Tomomi , Kamio Naoto , Okabe Tatsu , Muromachi Koichiro , Matsushima Kiyoshi 
Published: November 2015

ABSTRACTPlasma kallikrein (KLKB1), a serine protease, cleaves high‐molecular weight kininogen to produce bradykinin, a potent vasodilator and pro‐inflammatory peptide. In addition, KLKB1 activates plasminogen and other leukocyte and blood coagulation factors and processes pro‐enkephalin, prorenin, and C3. KLKB1 has also been shown to cleave protease‐activated receptors in vascular smooth muscle cells to regulate the expression of epidermal growth factor receptor. In this study, we investigated KLKB1‐dependent inflammation and activation of protease‐activated receptor‐1 in human dental pulp cells. These cells responded to KLKB1 stimulation by increasing intracellular Ca2+, upregulating cyclooxygenase‐2, and secreting prostaglandin E2. Remarkably, SCH79797, an antagonist of protease‐activated receptor‐1, blocked these effects. Thus, these data indicate that KLKB1 induces inflammatory reactions in human dental tissues via protease‐activated receptor 1. J. Cell. Biochem. 117: 1522–1528, 2016. © 2015 Wiley Periodicals, Inc.
Pomegranate peel extract decreases small intestine lipid peroxidation by enhancing activities of major antioxidant enzymes
Authors: Al‐Gubory Kaïs H , Blachier François , Faure Patrice , Garrel Catherine 
Published: November 2015

AbstractBACKGROUNDPomegranate peel extract (PPE) contains several compounds with antioxidative properties. PPE added to foods may interact with endogenous antioxidants and promote health. However, little is known about the biochemical mechanisms by which PPE exerts their actions on tissues of biological systems in vivo. The purpose of this study was to determine the effects of PPE on activities of antioxidant enzymes. Mice were used to investigate the effects of PPE on plasma levels of malondialdehyde (MDA), tissue MDA content and activities of superoxide dismutase 1 (SOD1), SOD2 and glutathione peroxidase (GPX) in the small intestine, liver and skeletal muscle – different tissues involved in the digestion, absorption and metabolism of dietary nutrients. Control mice were fed a standard diet, whereas treated mice were fed for 40 days with the standard diet containing 5% or 10% PPE.RESULTSMice fed the 10% PPE diet exhibited lower plasma MDA concentrations, reduced content of MDA in the small intestine and liver and higher levels of SOD1 and GPX activities in the small intestine compared to mice fed the control diet.CONCLUSIONSThese findings demonstrate that intake of PPE in diet attenuates small intestine lipid peroxidation and strengthens the first line of small intestine antioxidant defense by enhancing enzymatic antioxidative pathways. PPE is worthy of further study as a therapeutic approach to prevent peroxidative stress‐induced gut pathogenesis. © 2015 Society of Chemical Industry
Warmth and nociceptive evoked potentials in cold‐induced sweating syndrome type 1
Authors: Testani Elisa , Della Marca Giacomo , La Torraca Ilaria , Vollono Catello , Crisponi Giangiorgio , Zampino Giuseppe , Valeriani Massimiliano 
Published: November 2015

ABSTRACTIntroductionCold‐induced sweating syndrome type 1 (CISS1), is a rare, severe, autosomal recessive disease. It is characterized by morphological alterations and profuse sweating when ambient temperature is <22 °C. Although some individuals with CISS1 have decreased pain perception, no study has been conducted to evaluate thermal and pain sensations in these patients. The aim of this study was to assess the function of the nociceptive Aδ‐fibers and warmth C‐fibers by using CO2 laser‐evoked potentials (LEPs) in patients affected by CISS1.MethodsFour patients were studied. Laser pulses were applied to the skin of the right hand and the perioral region at painful intensity to record Aδ‐LEPs, and at non‐painful intensity to obtain C‐LEPs. Fifteen healthy subjects were studied for control purposes.ResultsNo significant difference in latencies or amplitudes of either Aδ‐ or C‐LEPs was found between the 2 groups.ConclusionCutaneous nociceptive and warmth pathway functions are normal in CISS1. Muscle Nerve 54: 100–103, 2016
Weight fluctuation during adulthood and weight gain since breast cancer diagnosis predict multiple dimensions of body image among rural breast cancer survivors
Authors: Fazzino Tera L. , Hunter Rebecca Clausius , Sporn Nora , Christifano Danielle N. , Befort Christie A. 
Published: November 2015

AbstractObjectiveObesity and weight gain after breast cancer treatment are common among survivors, yet the relationship between weight and body image has received little attention. The purpose of the current study was to examine the relationship between current body mass index, weight gain since diagnosis, and largest weight fluctuation in adulthood with six dimensions of body image among overweight/obese breast cancer survivors.MethodsThe current study used data obtained from a weight control trial with 210 rural overweight/obese breast cancer survivors. Using data collected at baseline, multiple regression models were constructed to examine the relative association of the three weight variables with breast cancer‐specific dimensions of body image while controlling for demographic characteristics and cancer treatment‐related variables.ResultsLargest weight fluctuation in adulthood significantly predicted overall body image (p = 0.01) and was associated with the three socially oriented dimensions of body image: social activity restriction, embarrassment about appearance, and sexuality (all ps = 0.01). Weight gain since diagnosis approached statistical significance in predicting overall body image (p = 0.05) and was associated with embarrassment about appearance (p = 0.03). Current body mass index was not significantly associated with overall body image when controlling for the other weight variables (p = 0.07) and was negatively associated with social activity restriction (p = 0.01) and sexuality (p = 0.01).ConclusionsObese breast cancer survivors with a history of a large weight fluctuation in adulthood may be prone to poorer breast cancer‐specific body image several years after treatment. Copyright © 2015 John Wiley & Sons, Ltd.
Changing Determinants of Low Fertility and Diffusion: a Spatial Analysis for Italy
Authors: Vitali Agnese , Billari Francesco C. 
Published: November 2015

AbstractItaly is a case study in lowest‐low fertility. Its internal heterogeneity is substantial and changing over time. The paper has two main aims. First, it aims at investigating whether the theoretical framework offered by the diffusionist perspective to fertility transition could still be relevant in explaining fertility changes in contemporary advanced societies. Second, the paper aims at investigating if and how the associations between fertility and a series of indicators of secularisation, female occupation, contribution of fertility of immigrants, and economic development change across space and over time. We make use of geographically weighted regressions and spatial panel regressions to model explicitly spatial dependence in fertility among Italian provinces over the period between 1999 and 2010. Results show that spatial dependence in provincial fertility persists even after controlling for standard correlates of fertility, consistently with a diffusionist perspective. Further, the local association between fertility and its correlates is not homogeneous across provinces. The strength and in some cases also the direction of such associations vary spatially, suggesting that the determinants of low fertility change across space. Finally, the associations between fertility and its correlates change over time. Copyright © 2015 John Wiley & Sons, Ltd.
Modelling the catenary effect in the progressive collapse analysis of concrete structures
Authors: Naji Arash 
Published: November 2015

AbstractProgressive collapse is a phenomenon in which local failure of a structural component due to a gas explosion or blast may lead to failure of the entire structure or a significant part of it. RC structures can resist progressive collapse through various mechanisms such as frame action and catenary action.In this paper, the effect of catenary action on the resistance of concrete frame structures to progressive collapse is modelled using limit analysis. Non‐linear optimization is performed for this. It is observed that although frame action is known to be the main mechanism resisting progressive collapse, at the end of this action, after rupture of bottom bars, catenary effects may bring about a noticeable increase in the resistance of the structure. The results show good agreement with the experimental results of other researchers.
Time‐variant reliability analysis of RC bridge girders subjected to corrosion – shear limit state
Authors: Vatteri Ahsana Parammel , Balaji Rao K. , Bharathan Anoop M. 
Published: November 2015

AbstractChloride‐induced corrosion of reinforced concrete (RC) bridge girders has led to a huge loss of national resources. One of the important concerns affecting RC bridge girders is corrosion of the stirrups, which can even cause the failure mechanism to change from a ductile flexural mode to a brittle shear mode. Hence, analysis of the reduction in shear capacity overtime is essential in the reliability assessment of bridge girders, which is the topic of the paper. This paper proposes a stochastic modelling approach for estimating the time‐variant shear capacity and reliability within the framework of a Monte Carlo simulation, which assists in the sustainability‐based service life design of bridge girders. Such modern design concepts require methodologies for estimating whole life cost at the design stage itself. The development of such methodologies would provide the designer with various options for arriving at an optimum design having the desired performance level during the service life. The proposed approach takes into account: 1) the randomness in basic variables, 2) the effect of micro‐environments and the spatial variation of corrosion, 3) the number of stirrups resisting web shear failure, and 4) the ductile to brittle transition of stirrup steel as corrosion propagates. The incorporation of this transition is found to have a significant influence on the time‐variant reliability of the girder. Although PFA concrete is known to have better durability characteristics than OPC concrete, this paper gives a framework for its quantification in terms of time‐variant reliability.
Properties of stabilized recycled plastic concretes made with three types of cement
Authors: Shaikh Faiz Uddin Ahmed , Mali Sarvesh 
Published: November 2015

AbstractThe growing concern for the ready‐mixed concrete industry is the disposal of returned unused concrete. In its plastic state, the concrete is a perishable product and the disposal of any unused concrete presents a set of challenges. An increase in environmental regulations requires the industry to implement the best practices that effectively reduce the quantity of by‐product materials requiring disposal. This paper describes a preliminary experimental study on the effect of commercial stabilizer on the plastic and hardened properties of concretes made with three different types of cement commonly used in Australia, namely, general‐purpose Portland cement (GP) (100 % ordinary Portland cement (OPC)), general‐purpose blended (GB) cement (75 % OPC + 25 % class F fly ash (FA)) and low‐heat (LH) cement (35 % OPC + 65 % blast‐furnace slag). The effect of various stabilizer dosages on the efflux time (flow time) of GP, GB and LH cement grouts was studied in the initial phase. The results show that for a constant efflux time, the holding duration of the grouts increases with increasing stabilizer dosages (or amounts) and in the case of GB and LH cement grouts, the holding duration is longer than the GP cement grout for the same stabilizer dosage. In the next phase, the predicted stabilizer dosage was added to concretes made with the above three cements to evaluate the plastic and hardened properties of fresh concretes, stabilized concretes and blends of fresh concretes with 10, 25 and 50 % stabilized concretes. The results show that the initial slump values are within the tolerance, except they are higher when the stabilizer dosage is added after 1 h, but the final slump is within the tolerance of the control concrete. After stabilization of the concretes, the initial and final setting times of stabilized concretes increased to > 24 h. The initial and final setting times of the blended concrete containing fresh concrete and 10, 25 and 50 % stabilized concretes are similar to those of fresh concrete for all cement types. The stabilized concretes do not have any significant effect on the compressive strength and shrinkage compared with the control concrete.
The sweet side ofRNAregulation: glyceraldehyde‐3‐phosphate dehydrogenase as a noncanonicalRNA‐binding protein
Authors: White Michael R. , Garcin Elsa D. 
Published: November 2015

The glycolytic protein, glyceraldehyde‐3‐phosphate dehydrogenase (GAPDH), has a vast array of extraglycolytic cellular functions, including interactions with nucleic acids.GAPDHhas been implicated in the translocation of transfer RNA (tRNA), the regulation of cellular messenger RNA (mRNA) stability and translation, as well as the regulation of replication and gene expression of many single‐strandedRNAviruses. A growing body of evidence supportsGAPDH–RNAinteractions serving as part of a larger coordination between intermediary metabolism andRNAbiogenesis. Despite the established role ofGAPDHin nucleic acid regulation, it is still unclear how and whereGAPDHbinds to itsRNAtargets, highlighted by the absence of any conservedRNA‐binding sequences. This review will summarize our current understanding ofGAPDH‐mediated regulation ofRNAfunction.WIREs RNA2016, 7:53–70. doi: 10.1002/wrna.1315This article is categorized under:RNA Interactions with Proteins and Other Molecules > Protein–RNA RecognitionRNA Interactions with Proteins and Other Molecules > RNA–Protein ComplexesRNA Interactions with Proteins and Other Molecules > Protein–RNA Interactions: Functional Implications